BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q24572 (430 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3C9C-A nrPDB 894 0.0 5Y1U-A nrPDB 802 0.0 3CFV-B nrPDB 757 0.0 5WJC-A nrPDB 415 e-116 4XYI-A nrPDB 378 e-105 4PSX-B nrPDB 265 4e-71 6MZM-G nrPDB 90 2e-18 6F3T-A nrPDB 89 4e-18 6HQA-B nrPDB 77 1e-14 5NNZ-B nrPDB 77 2e-14 6QX9-5O nrPDB 74 1e-13 5Y88-O nrPDB 72 5e-13 4V6W-Ag nrPDB 72 6e-13 4A11-B nrPDB 72 6e-13 4V8M-A7 nrPDB 71 1e-12 3DM0-A nrPDB 70 2e-12 3FM0-A nrPDB 70 2e-12 5MZH-A nrPDB 68 7e-12 2AQ5-A nrPDB 68 9e-12 5FL8-q nrPDB 64 1e-10 4BTS-AR nrPDB 63 2e-10 6G51-g nrPDB 61 9e-10 5NZU-C nrPDB 61 9e-10 6ID0-T nrPDB 60 1e-09 5G04-R nrPDB 60 1e-09 3W15-A nrPDB 60 1e-09 4GGA-A nrPDB 60 2e-09 5LCW-Q nrPDB 60 2e-09 4V7E-Bg nrPDB 60 2e-09 6QX9-4B nrPDB 60 2e-09 5YZG-W nrPDB 60 2e-09 6QDV-o nrPDB 60 2e-09 5OQL-d nrPDB 59 3e-09 5M25-A nrPDB 59 3e-09 2H9P-A nrPDB 59 5e-09 5GAN-H nrPDB 59 6e-09 4N14-A nrPDB 57 1e-08 5OPT-p nrPDB 57 2e-08 6HHQ-h nrPDB 57 2e-08 4AEZ-A nrPDB 57 2e-08 1VYH-C nrPDB 56 2e-08 5L9T-R nrPDB 56 4e-08 6N9G-C nrPDB 56 4e-08 5WYJ-BC nrPDB 54 2e-07 5OQL-L nrPDB 53 2e-07 5FA5-B nrPDB 53 2e-07 5OQL-J nrPDB 52 4e-07 3JB9-L nrPDB 52 4e-07 5A9Q-0 nrPDB 52 4e-07 5WLC-LU nrPDB 52 5e-07 2PM9-A nrPDB 51 1e-06 2YNP-A nrPDB 51 1e-06 3MKQ-A nrPDB 50 1e-06 1NR0-A nrPDB 50 2e-06 5Z56-q nrPDB 50 2e-06 4LG8-A nrPDB 49 3e-06 3JRP-A nrPDB 49 3e-06 4BZK-B nrPDB 49 3e-06 3JRO-A nrPDB 49 5e-06 4BH6-A nrPDB 49 5e-06 5A31-R nrPDB 49 6e-06 6ELZ-p nrPDB 49 6e-06 3JB9-g nrPDB 48 8e-06 4G56-B nrPDB 47 1e-05 3JAP-g nrPDB 47 2e-05 5UZ7-B nrPDB 46 3e-05 2HES-X nrPDB 45 4e-05 6J6H-n nrPDB 45 5e-05 5K1B-B nrPDB 45 6e-05 6F1U-h nrPDB 44 1e-04 3EI3-B nrPDB 44 1e-04 5XYI-g nrPDB 43 3e-04 6BX3-B nrPDB 42 4e-04 4L9O-A nrPDB 42 5e-04 4YCZ-A nrPDB 41 0.001 4E5Z-B nrPDB 41 0.001 5WLC-LS nrPDB 40 0.001 6EMK-B nrPDB 40 0.002 5WLC-LJ nrPDB 40 0.002 6BX3-A nrPDB 40 0.002 5LTD-A nrPDB 40 0.002 6EOJ-D nrPDB 40 0.002 6E29-D nrPDB 40 0.003 3BG0-A nrPDB 39 0.005 5CXC-A nrPDB 39 0.005 5BJS-A nrPDB 39 0.006 6Q8F-A nrPDB 38 0.007 6GMH-W nrPDB 38 0.008 4XFV-A nrPDB 37 0.015 5MWJ-A nrPDB 37 0.016 5WLC-LO nrPDB 37 0.023 5A9Q-2 nrPDB 36 0.032 4U1E-I nrPDB 36 0.034 5I2T-A nrPDB 36 0.037 5WLC-LW nrPDB 35 0.060 3JZG-A nrPDB 35 0.060 1PI6-A nrPDB 35 0.062 5WYJ-BE nrPDB 35 0.090 2P9P-C nrPDB 34 0.11 5YZG-2 nrPDB 34 0.16 5FVM-C nrPDB 33 0.19 5WBU-D nrPDB 33 0.19 4MDV-A nrPDB 33 0.21 5TF2-A nrPDB 33 0.26 3I2N-A nrPDB 33 0.27 4OWR-A nrPDB 33 0.30 4UPL-A nrPDB 33 0.33 5WYK-BB nrPDB 32 0.38 5A9Q-7 nrPDB 32 0.40 6CB1-s nrPDB 32 0.49 5CXB-B nrPDB 32 0.49 6C0F-s nrPDB 32 0.55 6EM1-m nrPDB 32 0.59 5N4A-A nrPDB 31 0.94 3F3P-A nrPDB 30 1.4 5M89-A nrPDB 30 1.6 5K0Y-T nrPDB 30 1.9 6CVZ-A nrPDB 29 3.3 4J0W-A nrPDB 29 3.3 4DI9-A nrPDB 29 3.7 6BM8-A nrPDB 29 4.7 3ODT-A nrPDB 28 5.2 3ISM-C nrPDB 28 5.2 5AJA-A nrPDB 28 6.1 6CHG-A nrPDB 28 7.8 >3C9C-A nrPDB Length = 432 Score = 894 bits (2311), Expect = 0.0, Method: Compositional matrix adjust. Identities = 430/430 (100%), Positives = 430/430 (100%) Query: 1 MVDRSDNAAESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQ 60 MVDRSDNAAESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQ Sbjct: 3 MVDRSDNAAESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQ 62 Query: 61 DGKDYSVHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIE 120 DGKDYSVHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIE Sbjct: 63 DGKDYSVHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIE 122 Query: 121 IEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGH 180 IEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGH Sbjct: 123 IEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGH 182 Query: 181 QKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH 240 QKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH Sbjct: 183 QKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH 242 Query: 241 LLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADK 300 LLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADK Sbjct: 243 LLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADK 302 Query: 301 TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 360 TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST Sbjct: 303 TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 362 Query: 361 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEI 420 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEI Sbjct: 363 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEI 422 Query: 421 PASELETNTA 430 PASELETNTA Sbjct: 423 PASELETNTA 432 >5Y1U-A nrPDB Length = 456 Score = 802 bits (2071), Expect = 0.0, Method: Compositional matrix adjust. Identities = 376/409 (91%), Positives = 400/409 (97%) Query: 11 SFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRL 70 +FDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVT+ +GKD+S+HRL Sbjct: 38 AFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRL 97 Query: 71 ILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGE 130 +LGTHTSDEQNHL+IASVQLP++DAQFD SHYD+EKGEFGGFGSV GKIEIEIKINHEGE Sbjct: 98 VLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGE 157 Query: 131 VNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWN 190 VNRARYMPQN C+IATKTPSSDVLVFDYTKHPSKP+PSGEC PDLRLRGHQKEGYGLSWN Sbjct: 158 VNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWN 217 Query: 191 PNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSV 250 PNL+G+LLSASDDHTICLWDI+A PKE +V+DAK IFTGHTAVVEDV+WHLLHESLFGSV Sbjct: 218 PNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSV 277 Query: 251 ADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 310 ADDQKLMIWDTR+NNTSKPSH+VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL Sbjct: 278 ADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 337 Query: 311 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPEL 370 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL+VWDLSKIGEEQS EDAEDGPPEL Sbjct: 338 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPEL 397 Query: 371 LFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPE 419 LFIHGGHTAKISDFSWNPNEPW+ICSVSEDNIMQVWQMAEN+YNDE+PE Sbjct: 398 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPE 446 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 42/165 (25%), Positives = 70/165 (42%), Gaps = 22/165 (13%) Query: 276 HTAEVNCLSFNPYSEFILATGSADKTVALWDLR------------NLKLKLHSFESHKDE 323 H EVN + P + I+AT + V ++D N L+L H+ E Sbjct: 154 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRL---RGHQKE 210 Query: 324 IFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISD 383 + + W+P+ L S+ D + +WD+S + +E DA+ I GHTA + D Sbjct: 211 GYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKT-------IFTGHTAVVED 263 Query: 384 FSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETN 428 SW+ + SV++D + +W N + + A E N Sbjct: 264 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVN 308 >3CFV-B nrPDB Length = 414 Score = 757 bits (1954), Expect = 0.0, Method: Compositional matrix adjust. Identities = 355/409 (86%), Positives = 386/409 (94%) Query: 8 AAESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSV 67 + E F+D VEERVINEEYKIWKKNTPFLYDLVMTHAL+WPSLT QWLP+VTK +GKDY++ Sbjct: 6 SKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDYAL 65 Query: 68 HRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINH 127 H L+LGTHTSDEQNHL++A V +P++DAQFD SH D++KGEFGGFGSV GKIE EIKINH Sbjct: 66 HWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKINH 125 Query: 128 EGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGL 187 EGEVNRARYMPQN +IATKTPSSDVLVFDYTKHP+KP+PSGEC PDLRLRGHQKEGYGL Sbjct: 126 EGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGL 185 Query: 188 SWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLF 247 SWN NL+G+LLSASDDHT+CLWDINA PKE +++DAK IFTGH+AVVEDVAWHLLHESLF Sbjct: 186 SWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLF 245 Query: 248 GSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL 307 GSVADDQKLMIWDTR+N TSKPSH VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL Sbjct: 246 GSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL 305 Query: 308 RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGP 367 RNLKLKLH+FESHKDEIFQV WSPHNETILASSGTDRRL+VWDLSKIGEEQS EDAEDGP Sbjct: 306 RNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGP 365 Query: 368 PELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDE 416 PELLFIHGGHTAKISDFSWNPNEPW+ICSVSEDNIMQ+WQMAEN+YNDE Sbjct: 366 PELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDE 414 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 38/165 (23%), Positives = 68/165 (41%), Gaps = 22/165 (13%) Query: 276 HTAEVNCLSFNPYSEFILATGSADKTVALWDLR------------NLKLKLHSFESHKDE 323 H EVN + P + I+AT + V ++D N L+L H+ E Sbjct: 125 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRL---RGHQKE 181 Query: 324 IFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISD 383 + + W+ + L S+ D + +WD++ +E DA+ I GH+A + D Sbjct: 182 GYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAK-------AIFTGHSAVVED 234 Query: 384 FSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETN 428 +W+ + SV++D + +W N + + A E N Sbjct: 235 VAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVN 279 >5WJC-A nrPDB Length = 430 Score = 415 bits (1066), Expect = e-116, Method: Compositional matrix adjust. Identities = 209/416 (50%), Positives = 280/416 (67%), Gaps = 15/416 (3%) Query: 18 ERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRLILGTHTS 77 ++ I EEYK+WK+N PFLYDLV+THALEWPSLT QWLPD G DYS+ RLILGTHTS Sbjct: 23 QKTIQEEYKLWKQNVPFLYDLVITHALEWPSLTIQWLPDKKTIPGTDYSIQRLILGTHTS 82 Query: 78 -DEQNHLLIASVQLPSED---AQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNR 133 ++QN+L IASVQLP+ D +F S + G + IEI KI H+G+VNR Sbjct: 83 GNDQNYLQIASVQLPNFDEDTTEFTPSTIRRAQAT-GSY-----TIEISQKIPHDGDVNR 136 Query: 134 ARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNL 193 ARYMPQ +IAT + +FD T H + +GE P L+GH EG+GL WNPNL Sbjct: 137 ARYMPQKPEIIATMGEGGNAYIFDTTCHDALT--TGEALPQAVLKGHTAEGFGLCWNPNL 194 Query: 194 NGYLLSASDDHTICLWDINA---TPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSV 250 G L + ++D ICLWD+ T E +VI + HT +V DV +H HE+L SV Sbjct: 195 PGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASV 254 Query: 251 ADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 310 +DD L I DTR N + + AH+ +N ++ NP+++++LAT SADKTVALWDLRN Sbjct: 255 SDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDLRNP 314 Query: 311 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPEL 370 +LH+ E H+DE++ ++WSPH+E ILASS TDRR+ +WDL KIGEEQ+ EDAEDG PEL Sbjct: 315 YQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPEL 374 Query: 371 LFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELE 426 LF+HGGHT +IS+FSW PNE W++ S+++DNI+Q+W + ++ + ++ +LE Sbjct: 375 LFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIWSPSRVIWGRDHVQVSPRDLE 430 >4XYI-A nrPDB Length = 430 Score = 378 bits (970), Expect = e-105, Method: Compositional matrix adjust. Identities = 195/418 (46%), Positives = 278/418 (66%), Gaps = 19/418 (4%) Query: 18 ERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRLILGTHTS 77 E+ I EEYK+WK+N PFLYDLV+T ALEWPSLT +W P + + S+ +L+LGT TS Sbjct: 23 EKKIQEEYKLWKQNVPFLYDLVITEALEWPSLTVEWFPGSERSLADNSSIQKLLLGTQTS 82 Query: 78 -DEQNHLLIASVQLPSEDAQFDGSHYD-----NEKGEFGGFGSVCGKIEIEIKINHEGEV 131 ++QN+L +ASVQLP+ D D N KG++G ++I KI+HEG+V Sbjct: 83 GNDQNYLQVASVQLPTFDDDLDDLTPSKMKPANFKGDYG--------LDIVQKIHHEGDV 134 Query: 132 NRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNP 191 N+AR+MPQN +IAT + + +FD + + +P + LR H EG+GL WN Sbjct: 135 NKARFMPQNPDIIATLGLNGNGYIFDLNLY--REQPIVQTGHQACLRHHTSEGFGLGWNF 192 Query: 192 NLNGYLLSASDDHTICLWDINATPKE-HRVIDAK--NIFTGHTAVVEDVAWHLLHESLFG 248 G L + ++D +IC+WDI + ID +++ HTAVV D+ +HL HE+L Sbjct: 193 IQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLT 252 Query: 249 SVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 308 SV+DD L I DTR ++S S V AH VN ++FNP+++++LAT SAD TVALWDLR Sbjct: 253 SVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLR 312 Query: 309 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPP 368 L +LH+ E H+DE++ VQWSPH+E IL +S TDRR+ VWDLSKIGEEQ+ ED+EDG P Sbjct: 313 RLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAP 372 Query: 369 ELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELE 426 EL+F+HGGHT ++SD SWNPN W++ S+++DNI+Q+W ++ ++ + +I + +LE Sbjct: 373 ELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSKVIWASDSLKIDSKDLE 430 >4PSX-B nrPDB Length = 401 Score = 265 bits (676), Expect = 4e-71, Method: Compositional matrix adjust. Identities = 143/395 (36%), Positives = 219/395 (55%), Gaps = 21/395 (5%) Query: 21 INEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRLILGTHTS-DE 79 ++EEY +WK N P +YD V L WPSLT QWLP ++ + LI+GTHTS +E Sbjct: 10 VDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELIIGTHTSGEE 69 Query: 80 QNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQ 139 +N+L A + LP E + + + + I I K HE E+ RARYMPQ Sbjct: 70 ENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQ 129 Query: 140 NACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLS 199 + ++AT ++ ++ Q L+ H+ GY LS++ + G LLS Sbjct: 130 DPNIVATINGQGTTFLYSRSEG---------LQSTLKF--HKDNGYALSFSTLVKGRLLS 178 Query: 200 ASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIW 259 SDDHT+ LW++ + + + N H+ ++ D WH ++ LFG+V++D L I Sbjct: 179 GSDDHTVALWEVGSGGDPTKPVRTWNDL--HSDIINDNKWHNFNKDLFGTVSEDSLLKIN 236 Query: 260 DTRNNNTSKPSHTVDAHTAE--VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF 317 D R NNT T+D N L+F+ +S +LA D V L+DLRN+K LH Sbjct: 237 DVRANNT-----TIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM 291 Query: 318 ESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGH 377 H+D + +++S H + ++ SSG+D RL +WDL +IG EQ+ +DAEDG PEL+ +H GH Sbjct: 292 SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGH 351 Query: 378 TAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENV 412 + ++DF NP PW++ S E+NI+QVW+ + ++ Sbjct: 352 RSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 >6MZM-G nrPDB Length = 800 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 72/233 (30%), Positives = 110/233 (47%), Gaps = 36/233 (15%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 L GH YG S++P+ N YLLS+S+D T+ LW + + + GH V D Sbjct: 539 LYGHSGPVYGASFSPDRN-YLLSSSEDGTVRLWSL-------QTFTCLVGYKGHNYPVWD 590 Query: 237 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATG 296 + + F S D+ +W T + +P H A+VNC F+P S ++ ATG Sbjct: 591 TQFSP-YGYYFVSGGHDRVARLWAT---DHYQPLRIFAGHLADVNCTRFHPNSNYV-ATG 645 Query: 297 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLS---K 353 SAD+TV LWD+ N + F HK I + +SP N LA+ TD R+ +WD+ Sbjct: 646 SADRTVRLWDVLNGNC-VRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGHGLM 703 Query: 354 IGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 +GE + GHT + ++ + I+ S S DN +++W Sbjct: 704 VGELK-----------------GHTDTVCSLRFS-RDGEILASGSMDNTVRLW 738 >6F3T-A nrPDB Length = 608 Score = 89.0 bits (219), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 72/233 (30%), Positives = 110/233 (47%), Gaps = 36/233 (15%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 L GH YG S++P+ N YLLS+S+D T+ LW + + + GH V D Sbjct: 347 LYGHSGPVYGASFSPDRN-YLLSSSEDGTVRLWSL-------QTFTCLVGYKGHNYPVWD 398 Query: 237 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATG 296 + + F S D+ +W T + +P H A+VNC F+P S ++ ATG Sbjct: 399 TQFSP-YGYYFVSGGHDRVARLWAT---DHYQPLRIFAGHLADVNCTRFHPNSNYV-ATG 453 Query: 297 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLS---K 353 SAD+TV LWD+ N + F HK I + +SP N LA+ TD R+ +WD+ Sbjct: 454 SADRTVRLWDVLNGNC-VRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGHGLM 511 Query: 354 IGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 +GE + GHT + ++ + I+ S S DN +++W Sbjct: 512 VGELK-----------------GHTDTVCSLRFS-RDGEILASGSMDNTVRLW 546 >6HQA-B nrPDB Length = 722 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 64/237 (27%), Positives = 107/237 (45%), Gaps = 29/237 (12%) Query: 176 RLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVE 235 RL GH YG+ ++P+ N YL+S S+D T+ LW ++ + GH++ V Sbjct: 448 RLVGHSGAVYGVDFSPD-NRYLISCSEDKTVRLWSLD-------TYTCLVSYKGHSSSVW 499 Query: 236 DVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILAT 295 DV + + F + + DQ +W + P H +V+C+ F+P S ++ T Sbjct: 500 DVKFSPMGH-YFATASHDQTARLWSC---DHIYPLRIFAGHLNDVDCVEFHPNSTYLF-T 554 Query: 296 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIG 355 GS+DKT +WD+ + + F H I + SP LAS+G D + +WD+S Sbjct: 555 GSSDKTARMWDIARGEC-VRVFMGHSGAINCLAVSPDGR-WLASAGEDSVVCLWDISTGR 612 Query: 356 EEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENV 412 ++ HG + FS E ++ S DN ++VW + +N Sbjct: 613 RIKAMRG-----------HGRSSIYSLAFS---REGTVLVSTGADNSVRVWDVKKNT 655 Score = 31.6 bits (70), Expect = 0.63, Method: Compositional matrix adjust. Identities = 31/104 (29%), Positives = 50/104 (48%), Gaps = 15/104 (14%) Query: 169 GECQPDLRL-RGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIF 227 GEC +R+ GH L+ +P+ +L SA +D +CLWDI+ R I A Sbjct: 569 GEC---VRVFMGHSGAINCLAVSPD-GRWLASAGEDSVVCLWDISTG----RRIKA---M 617 Query: 228 TGH-TAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPS 270 GH + + +A+ ++ S D + +WD + NT+ PS Sbjct: 618 RGHGRSSIYSLAFS-REGTVLVSTGADNSVRVWDVK-KNTNSPS 659 >5NNZ-B nrPDB Length = 415 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 64/210 (30%), Positives = 100/210 (47%), Gaps = 28/210 (13%) Query: 197 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 256 ++ S D T LWD A+ +E N GH VV +A++ + + + D+ Sbjct: 107 FITGSYDRTCKLWD-TASGEE------LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTC 159 Query: 257 MIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 316 +W T K HT HTAE+ CLSFNP S + ATGS D T LWD++N + ++++ Sbjct: 160 KLWSVE---TGKCYHTFRGHTAEIVCLSFNPQSTLV-ATGSMDTTAKLWDIQNGE-EVYT 214 Query: 317 FESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGG 376 H EI + ++ + I+ S D + VW DA+ G + I G Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGS-FDHTVVVW------------DADTGRKVNILI--G 259 Query: 377 HTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 H A+IS S+N + I+ + S D ++W Sbjct: 260 HCAEISSASFNWDCSLIL-TGSMDKTCKLW 288 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 66/244 (27%), Positives = 107/244 (43%), Gaps = 42/244 (17%) Query: 168 SGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIF 227 +G+C RGH E LS+NP + + + S D T LWDI + + ++ Sbjct: 166 TGKCYH--TFRGHTAEIVCLSFNPQ-STLVATGSMDTTAKLWDIQ---------NGEEVY 213 Query: 228 T--GHTAVVEDVAWHLLHESLF-GSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLS 284 T GH+A + ++++ + + GS D +++WD +T + + + H AE++ S Sbjct: 214 TLRGHSAEIISLSFNTSGDRIITGSF--DHTVVVWDA---DTGRKVNILIGHCAEISSAS 268 Query: 285 FNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS--GT 342 FN IL TGS DKT LWD N K + + H DEI + + I +S GT Sbjct: 269 FNWDCSLIL-TGSMDKTCKLWDATNGKC-VATLTGHDDEILDSCFDYTGKLIATASADGT 326 Query: 343 DRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNI 402 R I + + GH +IS S+NP ++ + S D Sbjct: 327 ARIFSAATRKCIAKLE-----------------GHEGEISKISFNPQGNHLL-TGSSDKT 368 Query: 403 MQVW 406 ++W Sbjct: 369 ARIW 372 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 48/174 (27%), Positives = 80/174 (45%), Gaps = 14/174 (8%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 L GH+ Y +++N + + S D T LW + H F GHTA + Sbjct: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYH-------TFRGHTAEIVC 182 Query: 237 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATG 296 ++++ +L + + D +WD +N + +T+ H+AE+ LSFN + I+ TG Sbjct: 183 LSFN-PQSTLVATGSMDTTAKLWDIQNG---EEVYTLRGHSAEIISLSFNTSGDRII-TG 237 Query: 297 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWD 350 S D TV +WD + K++ H EI ++ IL S D+ +WD Sbjct: 238 SFDHTVVVWDADTGR-KVNILIGHCAEISSASFNWDCSLILTGS-MDKTCKLWD 289 Score = 29.6 bits (65), Expect = 3.0, Method: Compositional matrix adjust. Identities = 15/35 (42%), Positives = 22/35 (62%), Gaps = 1/35 (2%) Query: 176 RLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWD 210 +L GH+ E +S+NP N +LL+ S D T +WD Sbjct: 340 KLEGHEGEISKISFNPQGN-HLLTGSSDKTARIWD 373 >6QX9-5O nrPDB Length = 357 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 78/337 (23%), Positives = 132/337 (39%), Gaps = 87/337 (25%) Query: 116 CGKIEIEIKI--NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQP 173 C ++ I + HEGEV ++ P N +A+ +L+++ G+C Sbjct: 52 CSSLQAPIMLLSGHEGEVYCCKFHP-NGSTLASAGFDRLILLWNVY---------GDCDN 101 Query: 174 DLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAV 233 L+GH L +N + L SAS D T+ +WD + R+ GHT+ Sbjct: 102 YATLKGHSGAVMELHYNTD-GSMLFSASTDKTVAVWDSETGERVKRL-------KGHTSF 153 Query: 234 VEDVAWHLLHESLFGSVADDQKLMIWDTRN------------------NNTS-------- 267 V L + +DD + +WD R N+TS Sbjct: 154 VNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGI 213 Query: 268 ------------KPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK-- 313 K ++T+ H V LS + ++L+ + D TV +WD+R K Sbjct: 214 DNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSN-AMDNTVRVWDVRPFAPKER 272 Query: 314 --------LHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED 365 +H+FE + + + WSP I A S DR ++VWD + Sbjct: 273 CVKIFQGNVHNFEKN---LLRCSWSPDGSKIAAGS-ADRFVYVWDTTS------------ 316 Query: 366 GPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNI 402 +L+ GH I++ +++P+EP II + S+ + Sbjct: 317 --RRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351 Score = 71.2 bits (173), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 62/244 (25%), Positives = 108/244 (44%), Gaps = 29/244 (11%) Query: 165 PEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAK 224 P S P + L GH+ E Y ++PN L SA D I LW++ D Sbjct: 50 PRCSSLQAPIMLLSGHEGEVYCCKFHPN-GSTLASAGFDRLILLWNVYGD------CDNY 102 Query: 225 NIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLS 284 GH+ V ++ ++ LF S + D+ + +WD+ K + HT+ VN Sbjct: 103 ATLKGHSGAVMELHYNTDGSMLF-SASTDKTVAVWDSETGERVK---RLKGHTSFVNSCY 158 Query: 285 FNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDR 344 ++ TGS D TV LWD+R K + +F+ + ++ V ++ ++ I+ S G D Sbjct: 159 PARRGPQLVCTGSDDGTVKLWDIRK-KAAIQTFQ-NTYQVLAVTFNDTSDQII-SGGIDN 215 Query: 345 RLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQ 404 + VWDL + +L + GH ++ S + +++ S + DN ++ Sbjct: 216 DIKVWDLRQ--------------NKLTYTMRGHADSVTGLSLSSEGSYLL-SNAMDNTVR 260 Query: 405 VWQM 408 VW + Sbjct: 261 VWDV 264 >5Y88-O nrPDB Length = 451 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 59/203 (29%), Positives = 100/203 (49%), Gaps = 15/203 (7%) Query: 150 SSDVLVFDYTKHPS-KPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICL 208 + +++V Y K S +PE + + GH ++ +P N + ++ S+D T+ + Sbjct: 107 AEELIVNRYEKLLSQRPEWHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKV 166 Query: 209 WDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSK 268 WD+ AT K K GH V DVA H LF SV++D+ + WD N + Sbjct: 167 WDL-ATGK------LKTTLAGHVMTVRDVAVSDRHPYLF-SVSEDKTVKCWDLEKNQIIR 218 Query: 269 PSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQ 328 + H + V +S +P + I AT D + LWD+R ++ + + HK I QVQ Sbjct: 219 DYY---GHLSGVRTVSIHPTLDLI-ATAGRDSVIKLWDMRT-RIPVITLVGHKGPINQVQ 273 Query: 329 WSPHNETILASSGTDRRLHVWDL 351 +P + +++SS TD + +WD+ Sbjct: 274 CTPVDPQVVSSS-TDATVRLWDV 295 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 34/145 (23%), Positives = 63/145 (43%), Gaps = 17/145 (11%) Query: 268 KPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQV 327 K S ++ H V C++ +P TGS D T+ +WDL KLK + H + V Sbjct: 130 KLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKT-TLAGHVMTVRDV 188 Query: 328 QWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWN 387 S + + + S D+ + WDL K +++ + GH + + S + Sbjct: 189 AVSDRHPYLFSVS-EDKTVKCWDLEK--------------NQIIRDYYGHLSGVRTVSIH 233 Query: 388 PNEPWIICSVSEDNIMQVWQMAENV 412 P +I + D+++++W M + Sbjct: 234 PTLD-LIATAGRDSVIKLWDMRTRI 257 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 45/161 (27%), Positives = 73/161 (45%), Gaps = 21/161 (13%) Query: 196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 255 YL S S+D T+ WD+ K + D + GH + V V+ H + L + D Sbjct: 196 YLFSVSEDKTVKCWDLE---KNQIIRD----YYGHLSGVRTVSIHPTLD-LIATAGRDSV 247 Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL---RNLKL 312 + +WD R T P T+ H +N + P ++++ S D TV LWD+ + +K+ Sbjct: 248 IKLWDMR---TRIPVITLVGHKGPINQVQCTPVDPQVVSS-STDATVRLWDVVAGKTMKV 303 Query: 313 KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSK 353 H HK + P E +AS+ TD + W L++ Sbjct: 304 LTH----HKRSVRATALHP-KEFSVASACTD-DIRSWGLAE 338 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 43/200 (21%), Positives = 85/200 (42%), Gaps = 23/200 (11%) Query: 211 INATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPS 270 ++ P+ H + GH V VA + F + ++D + +WD T K Sbjct: 119 LSQRPEWHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDL---ATGKLK 175 Query: 271 HTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWS 330 T+ H V ++ + ++ + S DKTV WDL ++ + + H + V Sbjct: 176 TTLAGHVMTVRDVAVSDRHPYLFSV-SEDKTVKCWDLEKNQI-IRDYYGHLSGVRTVSIH 233 Query: 331 PHNETILASSGTDRRLHVWDL-SKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPN 389 P + ++A++G D + +WD+ ++I P + + GH I+ P Sbjct: 234 PTLD-LIATAGRDSVIKLWDMRTRI-------------PVITLV--GHKGPINQVQCTPV 277 Query: 390 EPWIICSVSEDNIMQVWQMA 409 +P ++ S S D +++W + Sbjct: 278 DPQVVSS-STDATVRLWDVV 296 >4V6W-Ag nrPDB Length = 318 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 79/298 (26%), Positives = 133/298 (44%), Gaps = 36/298 (12%) Query: 125 INHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEG 184 I H G V + P++ I + + ++V+ T+ E + P RL GH Sbjct: 12 IGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRD----EDTNYGYPQKRLYGHSHFI 67 Query: 185 YGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHE 244 + + + N Y LS S D T+ LWD+ A R F GHT V VA+ + Sbjct: 68 SDVVLSSDGN-YALSGSWDQTLRLWDLAAGKTTRR-------FEGHTKDVLSVAFSADNR 119 Query: 245 SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP-YSEFILATGSADKTVA 303 + S + D+ + +W+T K + D HT V+C+ F+P +S I+ + D+TV Sbjct: 120 QIV-SGSRDKTIKLWNTLAE--CKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVK 176 Query: 304 LWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDA 363 +W+L N KLK ++ H + V SP + ++ S G D + +WDL+ G+ T + Sbjct: 177 VWNLANCKLK-NNHHGHNGYLNTVTVSP-DGSLCTSGGKDSKALLWDLND-GKNLYTLEH 233 Query: 364 EDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMA-ENVYNDEEPEI 420 D L F +PN W+ V+ +++W +A + + PE+ Sbjct: 234 NDIINALCF--------------SPNRYWLC--VAYGPSIKIWDLACKKTVEELRPEV 275 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 63/249 (25%), Positives = 116/249 (46%), Gaps = 28/249 (11%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 L GH ++ NP ++SAS D T+ +W + + K ++ GH+ + D Sbjct: 11 LIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLY-GHSHFISD 69 Query: 237 VAWHLLHESLFG-SVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILAT 295 V L + + S + DQ L +WD T++ + HT +V ++F+ + I++ Sbjct: 70 VV--LSSDGNYALSGSWDQTLRLWDLAAGKTTR---RFEGHTKDVLSVAFSADNRQIVS- 123 Query: 296 GSADKTVALWD-LRNLKLKLHSFESHKDEIFQVQWSP-HNETILASSGTDRRLHVWDLSK 353 GS DKT+ LW+ L K + + H D + V++SP H+ I+ S G DR + VW+L+ Sbjct: 124 GSRDKTIKLWNTLAECKFTIQE-DGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLAN 182 Query: 354 IGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM--AEN 411 + + H GH ++ + +P+ + S +D+ +W + +N Sbjct: 183 CKLKNN--------------HHGHNGYLNTVTVSPDGS-LCTSGGKDSKALLWDLNDGKN 227 Query: 412 VYNDEEPEI 420 +Y E +I Sbjct: 228 LYTLEHNDI 236 Score = 28.1 bits (61), Expect = 8.0, Method: Compositional matrix adjust. Identities = 35/152 (23%), Positives = 59/152 (38%), Gaps = 22/152 (14%) Query: 272 TVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL-----RNLKLKLHSFESHKDEIFQ 326 T+ H V ++ NP + + S DKT+ +W L N H I Sbjct: 10 TLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISD 69 Query: 327 VQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSW 386 V S L+ S D+ L +WDL+ + E GHT + ++ Sbjct: 70 VVLSSDGNYALSGSW-DQTLRLWDLAAGKTTRRFE--------------GHTKDVLSVAF 114 Query: 387 NPNEPWIICSVSEDNIMQVWQ-MAENVYNDEE 417 + + I+ S S D +++W +AE + +E Sbjct: 115 SADNRQIV-SGSRDKTIKLWNTLAECKFTIQE 145 >4A11-B nrPDB Length = 408 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 59/223 (26%), Positives = 97/223 (43%), Gaps = 20/223 (8%) Query: 196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTG------HTAVVEDVAWHLLHESLFGS 249 Y+LS D I L+D+ + ++ G H VE V W+ +F S Sbjct: 58 YMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTS 117 Query: 250 VADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLS--FNPYS--EFILATGSADKTVALW 305 + D+ L +WDT NT + T D E S +P S ++A G+ V L Sbjct: 118 SSFDKTLKVWDT---NTLQ---TADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLC 171 Query: 306 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED 365 DL++ H + H+ EI V WSP + ILA++ D R+ +WD+ + T D + Sbjct: 172 DLKSGSCS-HILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHN 230 Query: 366 GPPELLF--IHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 G + H K++ + + ++ +V DN M++W Sbjct: 231 GKKSQAVESANTAHNGKVNGLCFTSDGLHLL-TVGTDNRMRLW 272 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 23/180 (12%) Query: 187 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 246 + W P+ G S+S D T+ +WD N + +++ H + V L Sbjct: 105 VQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVST------KHCL 158 Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 K+ + D ++ + S H + H E+ +S++P ++ILAT SAD V LWD Sbjct: 159 VAVGTRGPKVQLCDLKSGSCS---HILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 Query: 307 LRNLKLKLHSFESH---KDEIFQVQWSPHNETI-----------LASSGTDRRLHVWDLS 352 +R L + + H K + + + HN + L + GTD R+ +W+ S Sbjct: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 36/175 (20%), Positives = 65/175 (37%), Gaps = 42/175 (24%) Query: 276 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF------------ESHKDE 323 H +N L P + +G +D + L+DL N + + + H+ Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 324 IFQVQWSPHNETILASSGTDRRLHVWD--------------------LSKIGEEQSTEDA 363 + VQW PH+ + SS D+ L VWD +S + + Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 Query: 364 EDGPPELLF----------IHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 P++ I GH +I SW+P +I+ + S D+ +++W + Sbjct: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 >4V8M-A7 nrPDB Length = 318 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 77/292 (26%), Positives = 132/292 (45%), Gaps = 44/292 (15%) Query: 123 IKINHEGEVNRAR-YMPQNACVIATKTPSSDVLVFDYTKHPS----KPEP---SGECQ-- 172 + + +EG++ R ++ AC +TP + V ++ + P P S EC Sbjct: 1 MAVAYEGQLTGHRGWVTSLAC---PQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYG 57 Query: 173 -PDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHT 231 PD RL GH ++ + N N + +SAS DH++ LW++ +++ F GHT Sbjct: 58 LPDRRLEGHSAFVSDVALSNNGN-FAVSASWDHSLRLWNLQNGQCQYK-------FLGHT 109 Query: 232 AVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEF 291 V VA+ + + S D L +W+ + S AHT V+C+ F+P + Sbjct: 110 KDVLSVAFSPDNRQIV-SGGRDNALRVWNVKGECMHTLSR--GAHTDWVSCVRFSPSLDA 166 Query: 292 -ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWD 350 ++ +G D V +WDL +L + + H + + V SP + ++ ASS D +WD Sbjct: 167 PVIVSGGWDNLVKVWDLATGRL-VTDLKGHTNYVTSVTVSP-DGSLCASSDKDGVARLWD 224 Query: 351 LSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNI 402 L+K E +E A P I+ ++PN W +C+ +E I Sbjct: 225 LTK--GEALSEMAAGAP-------------INQICFSPNRYW-MCAATEKGI 260 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 53/227 (23%), Positives = 99/227 (43%), Gaps = 29/227 (12%) Query: 191 PNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNI----FTGHTAVVEDVAWHLLHESL 246 P ++S S D T+ W N P H + + GH+A V DVA L + Sbjct: 25 PETATKVVSTSRDKTLLSWGPN--PDRHSSECSYGLPDRRLEGHSAFVSDVA--LSNNGN 80 Query: 247 FGSVAD-DQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 305 F A D L +W+ +N + HT +V ++F+P + I+ +G D + +W Sbjct: 81 FAVSASWDHSLRLWNLQNGQCQ---YKFLGHTKDVLSVAFSPDNRQIV-SGGRDNALRVW 136 Query: 306 DLRNLKLKLHSFESHKDEIFQVQWSPH-NETILASSGTDRRLHVWDLSKIGEEQSTEDAE 364 +++ + S +H D + V++SP + ++ S G D + VWDL+ Sbjct: 137 NVKGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLAT----------- 185 Query: 365 DGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 L+ GHT ++ + +P+ + S +D + ++W + + Sbjct: 186 ---GRLVTDLKGHTNYVTSVTVSPDGS-LCASSDKDGVARLWDLTKG 228 >3DM0-A nrPDB Length = 694 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 70/270 (25%), Positives = 120/270 (44%), Gaps = 34/270 (12%) Query: 140 NACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLS 199 NA +I + + ++++ TK + G Q L H E LS + + LS Sbjct: 394 NADIIVSASRDKSIILWKLTKDD---KAYGVAQRRLTGHSHFVEDVVLSSDGQ---FALS 447 Query: 200 ASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIW 259 S D + LWD+ A R F GHT V VA+ L + + S + D+ + +W Sbjct: 448 GSWDGELRLWDLAAGVSTRR-------FVGHTKDVLSVAFSLDNRQIV-SASRDRTIKLW 499 Query: 260 DTRNNNTSKPSHTVDAHTAEVNCLSFNPYS-EFILATGSADKTVALWDLRNLKLKLHSFE 318 +T S + H V+C+ F+P + + + + S DKTV +W+L N KL+ + Sbjct: 500 NTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLR-STLA 558 Query: 319 SHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHT 378 H + V SP + ++ AS G D + +WDL++ + S E Sbjct: 559 GHTGYVSTVAVSP-DGSLCASGGKDGVVLLWDLAEGKKLYSLE---------------AN 602 Query: 379 AKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 + I ++PN W +C+ +E I ++W + Sbjct: 603 SVIHALCFSPNRYW-LCAATEHGI-KIWDL 630 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 50/192 (26%), Positives = 90/192 (46%), Gaps = 23/192 (11%) Query: 224 KNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIW----DTRNNNTSKPSHTVDAHTAE 279 K HT +V +A + + + S + D+ +++W D + ++ T +H E Sbjct: 375 KGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVE 434 Query: 280 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS 339 LS + +F L +GS D + LWDL + F H ++ V +S N I+++ Sbjct: 435 DVVLSSD--GQFAL-SGSWDGELRLWDLA-AGVSTRRFVGHTKDVLSVAFSLDNRQIVSA 490 Query: 340 SGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPN--EPWIICSV 397 S DR + +W+ +GE + T +E G GH +S ++PN +P I+ S Sbjct: 491 S-RDRTIKLWN--TLGECKYTI-SEGGE--------GHRDWVSCVRFSPNTLQPTIV-SA 537 Query: 398 SEDNIMQVWQMA 409 S D ++VW ++ Sbjct: 538 SWDKTVKVWNLS 549 >3FM0-A nrPDB Length = 345 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 98/211 (46%), Gaps = 12/211 (5%) Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 GHQ+ ++W+P N YL SAS D T C+W K + GH V+ VA Sbjct: 59 GHQRTVRKVAWSPCGN-YLASASFDATTCIWK-----KNQDDFECVTTLEGHENEVKSVA 112 Query: 239 WHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSA 298 W +L + + D+ + +W+ + + +++HT +V + ++P E +LA+ S Sbjct: 113 W-APSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQE-LLASASY 170 Query: 299 DKTVALW-DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEE 357 D TV L+ + + + + E H+ ++ + + P + LAS DR + +W G E Sbjct: 171 DDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQR-LASCSDDRTVRIWRQYLPGNE 229 Query: 358 QSTEDAEDGPP--ELLFIHGGHTAKISDFSW 386 Q + P + + G H+ I D +W Sbjct: 230 QGVACSGSDPSWKCICTLSGFHSRTIYDIAW 260 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 42/143 (29%), Positives = 69/143 (48%), Gaps = 15/143 (10%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDA------KNIFT-- 228 L GH+ + L+++P+ L S SDD T+ +W E V + K I T Sbjct: 190 LEGHESTVWSLAFDPS-GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLS 248 Query: 229 -GHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPS-----HTVDAHTAEVNC 282 H+ + D+AW L +L + DD + + N++ +P+ H AH+ +VNC Sbjct: 249 GFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNC 308 Query: 283 LSFNPYSEFILATGSADKTVALW 305 +++NP +LA+ S D VA W Sbjct: 309 VAWNPKEPGLLASCSDDGEVAFW 331 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 41/186 (22%), Positives = 78/186 (41%), Gaps = 34/186 (18%) Query: 245 SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 304 +L S D+++ IW T ++ S + H V ++++P + LA+ S D T + Sbjct: 29 TLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNY-LASASFDATTCI 87 Query: 305 WDLRNLKLK-LHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDA 363 W + + + E H++E+ V W+P +LA+ D+ + VW++ D Sbjct: 88 WKKNQDDFECVTTLEGHENEVKSVAWAPSG-NLLATCSRDKSVWVWEV----------DE 136 Query: 364 EDGPPELLFIHGGHTAKISDFSWNPNEP--------------------WIICSVSEDNIM 403 ED E + + HT + W+P++ W+ C+ E + Sbjct: 137 ED-EYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHES 195 Query: 404 QVWQMA 409 VW +A Sbjct: 196 TVWSLA 201 Score = 29.3 bits (64), Expect = 3.1, Method: Compositional matrix adjust. Identities = 24/102 (23%), Positives = 45/102 (44%), Gaps = 14/102 (13%) Query: 307 LRNLKLKLHSFESHKD-EIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED 365 +++ + L +H D + + W+P T+LAS G DRR+ +W G E + + Sbjct: 1 MKDSLVLLGRVPAHPDSRCWFLAWNPAG-TLLASCGGDRRIRIW-----GTEGDSWICKS 54 Query: 366 GPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 + GH + +W+P ++ S S D +W+ Sbjct: 55 ------VLSEGHQRTVRKVAWSPCGNYLA-SASFDATTCIWK 89 >5MZH-A nrPDB Length = 452 Score = 68.2 bits (165), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 70/266 (26%), Positives = 116/266 (43%), Gaps = 36/266 (13%) Query: 144 IATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDD 203 IA P D +V K + Q L+GHQ E LS+NP + + + S D Sbjct: 142 IAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQ-STIIATGSMD 200 Query: 204 HTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLF-GSVADDQKLMIWDTR 262 +T LWD+ T +E + GH A + + ++ + + GS D +L WD R Sbjct: 201 NTAKLWDVE-TGQE------RATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRL--WDVR 251 Query: 263 NNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKD 322 T + H + H EV+ FN Y+ ++ +GS D T LWD+R+ + L + H D Sbjct: 252 ---TGQCVHVLSGHRGEVSSTQFN-YAGTLVVSGSIDCTSRLWDVRSGRC-LSVKQGHTD 306 Query: 323 EIFQVQWSPHNETILASS--GTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAK 380 E+ V + ++++S G+ R H L+ + + GH + Sbjct: 307 EVLDVAFDAAGTKMVSASADGSARLYHT--LTGVCQHTLV---------------GHEGE 349 Query: 381 ISDFSWNPNEPWIICSVSEDNIMQVW 406 IS ++NP +I + S D ++W Sbjct: 350 ISKVAFNPQGTRLI-TASSDKTCRLW 374 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 44/157 (28%), Positives = 78/157 (49%), Gaps = 22/157 (14%) Query: 253 DQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFN-PYSEFILATGSADKTVALWDLRNLK 311 D+ +W N T + T++ H V ++FN PY + I+ TGS DKT LWD + Sbjct: 115 DRTCKVW---NTFTGEEVFTLEGHKNVVYAIAFNNPYGDKIV-TGSFDKTCKLWDAYTGQ 170 Query: 312 LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELL 371 L ++ + H+ EI + ++P + TI+A+ D +WD+ + G+E++T Sbjct: 171 L-YYTLKGHQTEIVCLSFNPQS-TIIATGSMDNTAKLWDV-ETGQERATL---------- 217 Query: 372 FIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 GH A+I +N I+ + S D+ ++W + Sbjct: 218 ---AGHRAEIVSLGFNTGGDLIV-TGSFDHDSRLWDV 250 Score = 29.3 bits (64), Expect = 3.4, Method: Compositional matrix adjust. Identities = 24/87 (27%), Positives = 42/87 (48%), Gaps = 16/87 (18%) Query: 125 INHEGEVNRARYMPQNACVIATKTPSSD--VLVFDYTKHPSKPEPSGECQPDLRLRGHQK 182 + HEGE+++ + PQ +I T SSD ++D +GEC L GH Sbjct: 344 VGHEGEISKVAFNPQGTRLI---TASSDKTCRLWDC--------DTGECLQ--VLEGHTD 390 Query: 183 EGYGLSWNPNLNGYLLSASDDHTICLW 209 E + ++N ++++ S D+T +W Sbjct: 391 EIFSCAFNYE-GDFIITGSKDNTCRIW 416 >2AQ5-A nrPDB Length = 402 Score = 67.8 bits (164), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 45/196 (22%), Positives = 90/196 (45%), Gaps = 9/196 (4%) Query: 163 SKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVID 222 +P + +C D+R+ + + NP + AS + + K RV Sbjct: 16 GQPAKADQCYEDVRVSQTTWDSGFCAVNPKFMALICEASGGGAFLVLPLG---KTGRVDK 72 Query: 223 AKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNN----TSKPSHTVDAHTA 278 + GHTA V D+AW ++++ S ++D +M+W+ + +P T++ HT Sbjct: 73 NVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTK 132 Query: 279 EVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH-SFESHKDEIFQVQWSPHNETIL 337 V ++++P ++ +L + D + +WD+ L + H D I+ V WS + ++ Sbjct: 133 RVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWS-RDGALI 191 Query: 338 ASSGTDRRLHVWDLSK 353 +S D+R+ V + K Sbjct: 192 CTSCRDKRVRVIEPRK 207 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 28/115 (24%), Positives = 46/115 (40%), Gaps = 19/115 (16%) Query: 295 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKI 354 TG DK V L H + + W PHN+ ++AS D + VW++ Sbjct: 67 TGRVDKNVPL------------VCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDG 114 Query: 355 GEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMA 409 G E + GHT ++ +W+P ++ S DN++ VW + Sbjct: 115 GLVLPLR-------EPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVG 162 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 46/209 (22%), Positives = 80/209 (38%), Gaps = 44/209 (21%) Query: 121 IEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGEC-----QPDL 175 + + H V + P N VIA+ + V+V++ P G +P + Sbjct: 74 VPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEI--------PDGGLVLPLREPVI 125 Query: 176 RLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTG---HTA 232 L GH K ++W+P LLSA D+ I +WD+ A + G H Sbjct: 126 TLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGT--------GAAVLTLGPDVHPD 177 Query: 233 VVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNT----------SKPSHTVDAHTAEVNC 282 + V W +L + D+++ + + R ++P H V ++ Sbjct: 178 TIYSVDWS-RDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSEGKILT 236 Query: 283 LSFNPYSEFILATGSADKTVALWDLRNLK 311 F+ SE + VALWD ++L+ Sbjct: 237 TGFSRMSE---------RQVALWDTKHLE 256 Score = 34.3 bits (77), Expect = 0.10, Method: Compositional matrix adjust. Identities = 18/47 (38%), Positives = 26/47 (55%), Gaps = 2/47 (4%) Query: 376 GHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN--VYNDEEPEI 420 GHTA + D +W P+ +I S SED + VW++ + V EP I Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVI 125 >5FL8-q nrPDB Length = 515 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/268 (22%), Positives = 111/268 (41%), Gaps = 56/268 (20%) Query: 171 CQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGH 230 CQ + GH + W G L S S D T+ +WDIN+ + ++ + + H Sbjct: 270 CQ--YTMSGHTNSVSCVKWGGQ--GLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNH 325 Query: 231 TAVVEDVAWHLL--------------------------------HESLFGSVADDQKLMI 258 ++ D A + E + + +DD + + Sbjct: 326 LSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFL 385 Query: 259 WDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFE 318 W+ ++KP + H VN ++F+P +I++ S D ++ LWD R+ K + +F Sbjct: 386 WNPL--KSTKPIARMTGHQKLVNHVAFSPDGRYIVS-ASFDNSIKLWDGRDGKF-ISTFR 441 Query: 319 SHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHT 378 H ++QV WS + +L S D L VWD+ ++ + + D P GH Sbjct: 442 GHVASVYQVAWS-SDCRLLVSCSKDTTLKVWDV------RTRKLSVDLP--------GHK 486 Query: 379 AKISDFSWNPNEPWIICSVSEDNIMQVW 406 ++ W+ + +CS +D ++++W Sbjct: 487 DEVYTVDWSVDGK-RVCSGGKDKMVRLW 513 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 59/196 (30%), Positives = 95/196 (48%), Gaps = 23/196 (11%) Query: 156 FDYT-KHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWD-INA 213 FD+T K PS PE E Q L ++K N N +++ASDD+T+ LW+ + + Sbjct: 339 FDHTGKKPSTPE---EAQKKA-LENYEKI---CKKNGNSEEMMVTASDDYTMFLWNPLKS 391 Query: 214 TPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTV 273 T R+ TGH +V VA+ + S + D + +WD R+ K T Sbjct: 392 TKPIARM-------TGHQKLVNHVAFSPDGRYIV-SASFDNSIKLWDGRDG---KFISTF 440 Query: 274 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHN 333 H A V ++++ +L + S D T+ +WD+R KL + HKDE++ V WS Sbjct: 441 RGHVASVYQVAWSSDCR-LLVSCSKDTTLKVWDVRTRKLSV-DLPGHKDEVYTVDWSVDG 498 Query: 334 ETILASSGTDRRLHVW 349 + + S G D+ + +W Sbjct: 499 KRV-CSGGKDKMVRLW 513 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 44/172 (25%), Positives = 78/172 (45%), Gaps = 27/172 (15%) Query: 252 DDQKLMIWDTRNNNTSKP----SHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL 307 +DQ +++ R KP S + H + + C +F P++ + TG+ D T +WD Sbjct: 114 EDQITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDC 173 Query: 308 RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGP 367 + + +H+ + H + + V WSP E ++A+ D + +WD K G Q DA Sbjct: 174 -DTQTPMHTLKGHYNWVLCVSWSPDGE-VIATGSMDNTIRLWD-PKSG--QCLGDALR-- 226 Query: 368 PELLFIHGGHTAKISDFSWNP-------NEPWIICSVSEDNIMQVWQMAENV 412 GH+ I+ SW P ++P + S S+D +++W V Sbjct: 227 --------GHSKWITSLSWEPIHLVKPGSKP-RLASSSKDGTIKIWDTVSRV 269 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 74/310 (23%), Positives = 121/310 (39%), Gaps = 80/310 (25%) Query: 143 VIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW------NPNLNGY 196 VIAT + + + ++D SG+C D LRGH K LSW P Sbjct: 200 VIATGSMDNTIRLWD--------PKSGQCLGDA-LRGHSKWITSLSWEPIHLVKPGSKPR 250 Query: 197 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 256 L S+S D TI +WD + RV + +GHT V V W + L S + D+ + Sbjct: 251 LASSSKDGTIKIWDTVS-----RV--CQYTMSGHTNSVSCVKWG--GQGLLYSGSHDRTV 301 Query: 257 MIWDTRNNNTSKPSHTVDAHTAEVNCLSF------------------------------- 285 +WD N+ + + + +H VN LS Sbjct: 302 RVWDI--NSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALEN 359 Query: 286 -------NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 338 N SE ++ T S D T+ LW+ + H+ + V +SP I++ Sbjct: 360 YEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVS 419 Query: 339 SSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVS 398 +S D + +W D DG + + GH A + +W+ ++ ++ S S Sbjct: 420 AS-FDNSIKLW------------DGRDG--KFISTFRGHVASVYQVAWS-SDCRLLVSCS 463 Query: 399 EDNIMQVWQM 408 +D ++VW + Sbjct: 464 KDTTLKVWDV 473 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 40/186 (21%), Positives = 81/186 (43%), Gaps = 19/186 (10%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 + GH ++ P+ + +++ + D+T +WD + H GH V Sbjct: 139 IAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMH-------TLKGHYNWVLC 191 Query: 237 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPY------SE 290 V+W E + + + D + +WD ++ + H+ + LS+ P S+ Sbjct: 192 VSWSPDGE-VIATGSMDNTIRLWDPKSGQCL--GDALRGHSKWITSLSWEPIHLVKPGSK 248 Query: 291 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWD 350 LA+ S D T+ +WD + ++ ++ H + + V+W + +L S DR + VWD Sbjct: 249 PRLASSSKDGTIKIWDTVS-RVCQYTMSGHTNSVSCVKWG--GQGLLYSGSHDRTVRVWD 305 Query: 351 LSKIGE 356 ++ G Sbjct: 306 INSQGR 311 >4BTS-AR nrPDB Length = 343 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 54/185 (29%), Positives = 93/185 (50%), Gaps = 23/185 (12%) Query: 176 RLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVE 235 R GHQ E Y ++++P+ N +LSA + I LW+I E + A+ H+ V Sbjct: 113 RFVGHQSEVYSVAFSPD-NRQILSAGAEREIKLWNILG---ECKFSSAEK--ENHSDWVS 166 Query: 236 DVAWHLLHES---------LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFN 286 V + + +S F SV D +L +W+T + +T AH + VN LS + Sbjct: 167 CVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNT----NFQIRYTFKAHESNVNHLSIS 222 Query: 287 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 346 P ++I ATG DK + +WD+ NL F++ I Q+ ++P + + + GTD+ + Sbjct: 223 PNGKYI-ATGGKDKKLLIWDILNLTYPQREFDA-GSTINQIAFNPKLQWV--AVGTDQGV 278 Query: 347 HVWDL 351 +++L Sbjct: 279 KIFNL 283 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 60/264 (22%), Positives = 101/264 (38%), Gaps = 74/264 (28%) Query: 197 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFG-SVADDQK 255 L+S S D T+ +W + + TGH V D+A L E+ F S + D+ Sbjct: 42 LISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLA--LSQENCFAISSSWDKT 99 Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD-LRNLKLKL 314 L +WD R T K H +EV ++F+P + IL+ G A++ + LW+ L K Sbjct: 100 LRLWDLRTGTTYK---RFVGHQSEVYSVAFSPDNRQILSAG-AEREIKLWNILGECKFSS 155 Query: 315 HSFESHKDEIFQVQWSP------------------------------------------- 331 E+H D + V++SP Sbjct: 156 AEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNTNFQIRYTFKAHESN 215 Query: 332 -------HNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDF 384 N +A+ G D++L +WD+ + Q DA G T I+ Sbjct: 216 VNHLSISPNGKYIATGGKDKKLLIWDILNLTYPQREFDA------------GST--INQI 261 Query: 385 SWNPNEPWIICSVSEDNIMQVWQM 408 ++NP W+ +V D ++++ + Sbjct: 262 AFNPKLQWV--AVGTDQGVKIFNL 283 Score = 29.6 bits (65), Expect = 2.5, Method: Compositional matrix adjust. Identities = 24/108 (22%), Positives = 39/108 (36%), Gaps = 49/108 (45%) Query: 292 ILATGSADKTVALWDL-----------------------------------------RNL 310 +L +GS DKTV +W L + L Sbjct: 41 VLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSSWDKTL 100 Query: 311 KL-------KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 +L F H+ E++ V +SP N IL S+G +R + +W++ Sbjct: 101 RLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQIL-SAGAEREIKLWNI 147 >6G51-g nrPDB Length = 317 Score = 61.2 bits (147), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 62/244 (25%), Positives = 109/244 (44%), Gaps = 27/244 (11%) Query: 172 QPDLR--LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTG 229 Q LR L+GH ++ P +LSAS D TI +W + + + + G Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGI--PQRALRG 61 Query: 230 HTAVVEDVAWHLLHESLFG-SVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPY 288 H+ V DV + + F S + D L +WD T++ HT +V ++F+ Sbjct: 62 HSHFVSDVV--ISSDGQFALSGSWDGTLRLWDLTTGTTTRR---FVGHTKDVLSVAFSSD 116 Query: 289 SEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET-ILASSGTDRRLH 347 + I++ GS DKT+ LW+ + ESH + + V++SP++ I+ S G D+ + Sbjct: 117 NRQIVS-GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 Query: 348 VWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 VW+L+ +L H GHT ++ + +P+ + S +D +W Sbjct: 176 VWNLANC--------------KLKTNHIGHTGYLNTVTVSPDGS-LCASGGKDGQAMLWD 220 Query: 408 MAEN 411 + E Sbjct: 221 LNEG 224 >5NZU-C nrPDB Length = 905 Score = 61.2 bits (147), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 42/156 (26%), Positives = 73/156 (46%), Gaps = 17/156 (10%) Query: 251 ADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 310 ADD ++ ++ N NT + H +AH+ + C++ +P FIL T S D + LWD Sbjct: 76 ADDMQIRVF---NYNTLERVHMFEAHSDYIRCIAVHPTQPFIL-TSSDDMLIKLWDWDKK 131 Query: 311 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPEL 370 FE H + Q+ +P + AS+ DR + VW L + E E G + Sbjct: 132 WSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCI 191 Query: 371 LFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 + GG ++P++I S ++D ++++W Sbjct: 192 DYYSGG------------DKPYLI-SGADDRLVKIW 214 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 41/159 (25%), Positives = 73/159 (45%), Gaps = 20/159 (12%) Query: 196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 255 ++L++SDD I LWD + + +F GHT V + + + F S + D+ Sbjct: 113 FILTSSDDMLIKLWDWD------KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRT 166 Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSF-----NPYSEFILATGSADKTVALWDLRNL 310 + +W +S P+ T++ H VNC+ + PY L +G+ D+ V +WD +N Sbjct: 167 IKVWQL---GSSSPNFTLEGHEKGVNCIDYYSGGDKPY----LISGADDRLVKIWDYQN- 218 Query: 311 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 K + + E H + + P I+ S D + +W Sbjct: 219 KTCVQTLEGHAQNVSCASFHPELPIIITGS-EDGTVRIW 256 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 39/138 (28%), Positives = 60/138 (43%), Gaps = 12/138 (8%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 GH + NP N SAS D TI +W + ++ GH V Sbjct: 138 FEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNF-------TLEGHEKGVNC 190 Query: 237 VAWHLLHES-LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILAT 295 + ++ + S ADD+ + IWD +N + T++ H V+C SF+P I+ T Sbjct: 191 IDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQ---TLEGHAQNVSCASFHPELPIII-T 246 Query: 296 GSADKTVALWDLRNLKLK 313 GS D TV +W +L+ Sbjct: 247 GSEDGTVRIWHSSTYRLE 264 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 44/189 (23%), Positives = 76/189 (40%), Gaps = 20/189 (10%) Query: 221 IDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEV 280 +D K T + V+ V H + S+ + + +W N+ T T + V Sbjct: 5 LDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGS-VCVW---NHETQTLVKTFEVCDLPV 60 Query: 281 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 340 F +++ TG+ D + +++ L+ ++H FE+H D I + P IL SS Sbjct: 61 RAAKFVARKNWVV-TGADDMQIRVFNYNTLE-RVHMFEAHSDYIRCIAVHPTQPFILTSS 118 Query: 341 GTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSED 400 D + +WD K + S + GHT + NP + S S D Sbjct: 119 -DDMLIKLWDWDK---KWSCSQ----------VFEGHTHYVMQIVINPKDNNQFASASLD 164 Query: 401 NIMQVWQMA 409 ++VWQ+ Sbjct: 165 RTIKVWQLG 173 >6ID0-T nrPDB Length = 514 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 59/230 (25%), Positives = 97/230 (42%), Gaps = 23/230 (10%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRL----RGHQ 181 H G +R + N+ V+ T + L+ K P+ P+P + P +L GH Sbjct: 149 RHPGASDRPQPTAMNSIVMETGNTKNSALMAK--KAPTMPKP--QWHPPWKLYRVISGHL 204 Query: 182 KEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHL 241 ++ P N + ++ S D TI +WD+ + K TGH + V V Sbjct: 205 GWVRCIAVEPG-NQWFVTGSADRTIKIWDLASG-------KLKLSLTGHISTVRGVIVST 256 Query: 242 LHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKT 301 LF S +D+++ WD N + H H + V L +P + +L T S D T Sbjct: 257 RSPYLF-SCGEDKQVKCWDLEYNKVIRHYH---GHLSAVYGLDLHPTID-VLVTCSRDST 311 Query: 302 VALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 +WD+R K +H+ H + + V+ I+ S D + +WDL Sbjct: 312 ARIWDVRT-KASVHTLSGHTNAVATVRCQAAEPQIITGSH-DTTIRLWDL 359 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 61/237 (25%), Positives = 99/237 (41%), Gaps = 42/237 (17%) Query: 175 LRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVV 234 L L GH G+ + + YL S +D + WD+ + ++VI + GH + V Sbjct: 240 LSLTGHISTVRGVIVS-TRSPYLFSCGEDKQVKCWDL----EYNKVIRH---YHGHLSAV 291 Query: 235 EDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHT---AEVNCLSFNPYSEF 291 + H + L + + D IWD R T HT+ HT A V C + P Sbjct: 292 YGLDLHPTIDVLV-TCSRDSTARIWDVR---TKASVHTLSGHTNAVATVRCQAAEPQ--- 344 Query: 292 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 + TGS D T+ LWDL K ++ + +HK + V P + T +SG+ + W Sbjct: 345 -IITGSHDTTIRLWDLVAGKTRV-TLTNHKKSVRAVVLHPRHYTF--ASGSPDNIKQWKF 400 Query: 352 SKIGEEQSTEDAEDGPPELLFIH--GGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 P+ FI GH A I+ + N + ++ S +++ M +W Sbjct: 401 ----------------PDGSFIQNLSGHNAIINTLTVNSDG--VLVSGADNGTMHLW 439 >5G04-R nrPDB Length = 499 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 50/202 (24%), Positives = 84/202 (41%), Gaps = 11/202 (5%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 L GH +E GL W P+ +L S +D+ + +W + P E + + FT H V+ Sbjct: 305 LSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWP--SAPGEGGWVPLQT-FTQHQGAVKA 360 Query: 237 VAWHLLHESLF--GSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILA 294 VAW ++ G D+ + IW+ + VDAH+ + L Y E I Sbjct: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS---AVDAHSQVCSILWSPHYKELISG 417 Query: 295 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKI 354 G A + +W + K+ + H + + SP T+ AS+ D L +W ++ Sbjct: 418 HGFAQNQLVIWKYPTMA-KVAELKGHTSRVLSLTMSPDGATV-ASAAADETLRLWRCFEL 475 Query: 355 GEEQSTEDAEDGPPELLFIHGG 376 + E + + IH G Sbjct: 476 DPARRREREKASAAKSSLIHQG 497 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 32/117 (27%), Positives = 57/117 (48%), Gaps = 10/117 (8%) Query: 234 VEDVAWHLLHESLFGSVA-DDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI 292 + VAW + E + +V ++ +WD + K + +H+A V LS+N Y I Sbjct: 229 ISSVAW--IKEGNYLAVGTSSAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWNSY---I 280 Query: 293 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 L++GS + D+R + + + H E+ ++W+P LAS G D ++VW Sbjct: 281 LSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW 336 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 55/250 (22%), Positives = 99/250 (39%), Gaps = 50/250 (20%) Query: 196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 255 YL + + LWD+ ++ R+ + T H+A V ++W+ + S + Sbjct: 240 YLAVGTSSAEVQLWDVQ---QQKRLRN----MTSHSARVGSLSWN---SYILSSGSRSGH 289 Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK---L 312 + D R T+ H+ EV L + P LA+G D V +W + + Sbjct: 290 IHHHDVRV--AEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWV 346 Query: 313 KLHSFESHKDEIFQVQWSPHNETILASSG--TDRRLHVWDLSKIGEEQSTEDAED----- 365 L +F H+ + V W P +LA+ G +DR + +W++ G S DA Sbjct: 347 PLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAVDAHSQVCSI 405 Query: 366 --GP--PELLFIHG---------------------GHTAKISDFSWNPNEPWIICSVSED 400 P EL+ HG GHT+++ + +P+ + S + D Sbjct: 406 LWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVASAAAD 464 Query: 401 NIMQVWQMAE 410 +++W+ E Sbjct: 465 ETLRLWRCFE 474 >3W15-A nrPDB Length = 368 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 62/267 (23%), Positives = 113/267 (42%), Gaps = 33/267 (12%) Query: 173 PDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWD-------INATPKE-------- 217 P + H++E + +WN LS+S D +I +W + TP+ Sbjct: 98 PIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVD 157 Query: 218 --HRVIDAKNIFTG---HTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHT 272 + +I K FTG + V + ++L S + + ++D R + ++ Sbjct: 158 PLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNF 217 Query: 273 VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL---KLHSFE-------SHKD 322 + E FN Y +++ATG D + +WD+R L +LH+ +H Sbjct: 218 LVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGL 277 Query: 323 EIFQVQWSPHNETILASSGTDRRLHVW-DLSKIGEEQSTE-DAEDGPPELLFIHGGHTAK 380 I +V WSPH+ IL S+ D +W DLS G +++ + ++ D +F H+ Sbjct: 278 AIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEF 337 Query: 381 ISDFSWNP-NEPWIICSVSEDNIMQVW 406 + W+ +P + S + D + VW Sbjct: 338 VFGADWSLWGKPGYVASTAWDGNLFVW 364 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 57/253 (22%), Positives = 103/253 (40%), Gaps = 35/253 (13%) Query: 185 YGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHE 244 + L+WN + +L A D T+ L+D T KE + IF H V W+L++ Sbjct: 66 FDLAWNESHENQVLVAQGDGTLRLFD--TTFKEFPIA----IFKEHEREVFSCNWNLVNR 119 Query: 245 SLFGSVADDQKLMIWDTRNNN-----TSKP---SHTVDAHTAEV-------------NCL 283 F S + D + IW T +P + VD A + NC+ Sbjct: 120 QNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCV 179 Query: 284 ---SFNPYSEFILATGSADKTVALWDLRNLKLK-LHSFESHKD-EIFQVQWSPHNETILA 338 F+P+ + ++ + S + +L+D+R K ++F H E ++ + ++A Sbjct: 180 YQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVA 239 Query: 339 SSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVS 398 + G D + +WD+ + + E I H I +W+P+ I+ S S Sbjct: 240 TGGVDNAIRIWDIRMLNKNPGQLHNSSCINE---IPNAHGLAIRKVTWSPHHSNILMSAS 296 Query: 399 EDNIMQVWQMAEN 411 D ++W+ N Sbjct: 297 YDMTCRIWRDLSN 309 >4GGA-A nrPDB Length = 420 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 51/202 (25%), Positives = 84/202 (41%), Gaps = 11/202 (5%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 L GH +E GL W P+ +L S +D+ + +W + P E + + FT H V+ Sbjct: 226 LSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWP--SAPGEGGWVPLQT-FTQHQGAVKA 281 Query: 237 VAWHLLHESLF--GSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILA 294 VAW ++ G D+ + IW N + VDAH+ + L Y E I Sbjct: 282 VAWCPWQSNVLATGGGTSDRHIRIW---NVCSGACLSAVDAHSQVCSILWSPHYKELISG 338 Query: 295 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKI 354 G A + +W + K+ + H + + SP T+ AS+ D L +W ++ Sbjct: 339 HGFAQNQLVIWKYPTMA-KVAELKGHTSRVLSLTMSPDGATV-ASAAADETLRLWRCFEL 396 Query: 355 GEEQSTEDAEDGPPELLFIHGG 376 + E + + IH G Sbjct: 397 DPARRREREKASAAKSSLIHQG 418 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 32/117 (27%), Positives = 57/117 (48%), Gaps = 10/117 (8%) Query: 234 VEDVAWHLLHESLFGSVA-DDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI 292 + VAW + E + +V ++ +WD + K + +H+A V LS+N Y I Sbjct: 150 ISSVAW--IKEGNYLAVGTSSAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWNSY---I 201 Query: 293 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 L++GS + D+R + + + H E+ ++W+P LAS G D ++VW Sbjct: 202 LSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW 257 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 55/250 (22%), Positives = 99/250 (39%), Gaps = 50/250 (20%) Query: 196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 255 YL + + LWD+ ++ R+ + T H+A V ++W+ + S + Sbjct: 161 YLAVGTSSAEVQLWDVQ---QQKRLRN----MTSHSARVGSLSWN---SYILSSGSRSGH 210 Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK---L 312 + D R T+ H+ EV L + P LA+G D V +W + + Sbjct: 211 IHHHDVRV--AEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWV 267 Query: 313 KLHSFESHKDEIFQVQWSPHNETILASSG--TDRRLHVWDLSKIGEEQSTEDAED----- 365 L +F H+ + V W P +LA+ G +DR + +W++ G S DA Sbjct: 268 PLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAVDAHSQVCSI 326 Query: 366 --GP--PELLFIHG---------------------GHTAKISDFSWNPNEPWIICSVSED 400 P EL+ HG GHT+++ + +P+ + S + D Sbjct: 327 LWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVASAAAD 385 Query: 401 NIMQVWQMAE 410 +++W+ E Sbjct: 386 ETLRLWRCFE 395 >5LCW-Q nrPDB Length = 374 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 51/202 (25%), Positives = 84/202 (41%), Gaps = 11/202 (5%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 L GH +E GL W P+ +L S +D+ + +W + P E + + FT H V+ Sbjct: 180 LSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWP--SAPGEGGWVPLQT-FTQHQGAVKA 235 Query: 237 VAWHLLHESLF--GSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILA 294 VAW ++ G D+ + IW N + VDAH+ + L Y E I Sbjct: 236 VAWCPWQSNVLATGGGTSDRHIRIW---NVCSGACLSAVDAHSQVCSILWSPHYKELISG 292 Query: 295 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKI 354 G A + +W + K+ + H + + SP T+ AS+ D L +W ++ Sbjct: 293 HGFAQNQLVIWKYPTMA-KVAELKGHTSRVLSLTMSPDGATV-ASAAADETLRLWRCFEL 350 Query: 355 GEEQSTEDAEDGPPELLFIHGG 376 + E + + IH G Sbjct: 351 DPARRREREKASAAKSSLIHQG 372 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 32/117 (27%), Positives = 57/117 (48%), Gaps = 10/117 (8%) Query: 234 VEDVAWHLLHESLFGSVA-DDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI 292 + VAW + E + +V ++ +WD + K + +H+A V LS+N Y I Sbjct: 104 ISSVAW--IKEGNYLAVGTSSAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWNSY---I 155 Query: 293 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 L++GS + D+R + + + H E+ ++W+P LAS G D ++VW Sbjct: 156 LSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW 211 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 55/250 (22%), Positives = 99/250 (39%), Gaps = 50/250 (20%) Query: 196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 255 YL + + LWD+ ++ R+ + T H+A V ++W+ + S + Sbjct: 115 YLAVGTSSAEVQLWDVQ---QQKRLRN----MTSHSARVGSLSWN---SYILSSGSRSGH 164 Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK---L 312 + D R T+ H+ EV L + P LA+G D V +W + + Sbjct: 165 IHHHDVRV--AEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWV 221 Query: 313 KLHSFESHKDEIFQVQWSPHNETILASSG--TDRRLHVWDLSKIGEEQSTEDAED----- 365 L +F H+ + V W P +LA+ G +DR + +W++ G S DA Sbjct: 222 PLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAVDAHSQVCSI 280 Query: 366 --GP--PELLFIHG---------------------GHTAKISDFSWNPNEPWIICSVSED 400 P EL+ HG GHT+++ + +P+ + S + D Sbjct: 281 LWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVASAAAD 339 Query: 401 NIMQVWQMAE 410 +++W+ E Sbjct: 340 ETLRLWRCFE 349 >4V7E-Bg nrPDB Length = 380 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 48/180 (26%), Positives = 86/180 (47%), Gaps = 12/180 (6%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 L GH+ + P+ L++ S D T LWD+ T + I +GHTA V Sbjct: 153 LTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDV--TTGQRISIFGSEFPSGHTADVLS 210 Query: 237 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATG 296 ++ + L+ ++F S + D + +WD R TS+ T H ++N + F P + TG Sbjct: 211 LSINSLNANMFISGSCDTTVRLWDLR--ITSRAVRTYHGHEGDINSVKFFPDGQR-FGTG 267 Query: 297 SADKTVALWDLRNL-KLKLHSFESHKDE-----IFQVQWSPHNETILASSGTDRRLHVWD 350 S D T L+D+R +L++++ E +++ + V +S + A ++ +VWD Sbjct: 268 SDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGY-SNGDCYVWD 326 Score = 58.2 bits (139), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 50/214 (23%), Positives = 81/214 (37%), Gaps = 47/214 (21%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRV---------------- 220 L+GH + Y L W P N +++SAS D + +W+ + K H + Sbjct: 62 LQGHSGKVYSLDWTPEKN-WIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPNG 120 Query: 221 --------------------------IDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQ 254 + + TGH + E+ + + DQ Sbjct: 121 QSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQ 180 Query: 255 KLMIWD--TRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL 312 ++WD T + S HTA+V LS N + + +GS D TV LWDLR Sbjct: 181 TCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSR 240 Query: 313 KLHSFESHKDEIFQVQWSPHNETILASS--GTDR 344 + ++ H+ +I V++ P + S GT R Sbjct: 241 AVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCR 274 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 48/203 (23%), Positives = 85/203 (41%), Gaps = 25/203 (12%) Query: 229 GHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPY 288 GH+ V + W ++ S + D +L++W N TS+ +H + H V +F P Sbjct: 64 GHSGKVYSLDW-TPEKNWIVSASQDGRLIVW---NALTSQKTHAIKLHCPWVMECAFAPN 119 Query: 289 SEFILATGSADKTVALWDL-----RNLKLKL-HSFESHKDEIFQVQWSPHNETILASSGT 342 + + A G D ++++L R+ + + HK Q+ P ET L + Sbjct: 120 GQSV-ACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSG 178 Query: 343 DRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNI 402 D+ +WD++ G+ S +E GHTA + S N + S S D Sbjct: 179 DQTCVLWDVTT-GQRISIFGSE--------FPSGHTADVLSLSINSLNANMFISGSCDTT 229 Query: 403 MQVWQM-----AENVYNDEEPEI 420 +++W + A Y+ E +I Sbjct: 230 VRLWDLRITSRAVRTYHGHEGDI 252 Score = 32.7 bits (73), Expect = 0.29, Method: Compositional matrix adjust. Identities = 17/59 (28%), Positives = 27/59 (45%), Gaps = 3/59 (5%) Query: 350 DLSKIGEEQSTEDAEDGPPELLFIHG--GHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 D+ K + Q P +L+ GH+ K+ W P + WI+ S S+D + VW Sbjct: 36 DVEKYSKAQGRTAVSFNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIV-SASQDGRLIVW 93 >6QX9-4B nrPDB Length = 522 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 45/178 (25%), Positives = 87/178 (48%), Gaps = 14/178 (7%) Query: 172 QPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHT 231 +P + GH + W+P+ +L + D + LWD+ A + ++ + GH+ Sbjct: 314 EPVADIEGHTVRVARVMWHPS-GRFLGTTCYDRSWRLWDLEA---QEEILHQE----GHS 365 Query: 232 AVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEF 291 V D+A+H SL G+ D +WD R T + ++ H E+ ++F+P + + Sbjct: 366 MGVYDIAFHQ-DGSLAGTGGLDAFGRVWDLR---TGRCIMFLEGHLKEIYGINFSP-NGY 420 Query: 292 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 +ATGS D T +WDLR + +++ +H++ + V++ P + L + D +W Sbjct: 421 HIATGSGDNTCKVWDLRQRRC-VYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIW 477 Score = 34.7 bits (78), Expect = 0.078, Method: Compositional matrix adjust. Identities = 23/99 (23%), Positives = 41/99 (41%), Gaps = 5/99 (5%) Query: 251 ADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 310 + D +WD R + +T+ AH V + F P L TG+ D T +W Sbjct: 426 SGDNTCKVWDLRQR---RCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGW 482 Query: 311 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 L + H+ ++ + S + ++A+ DR +W Sbjct: 483 S-PLKTLAGHEGKVMGLDISSDGQ-LIATCSYDRTFKLW 519 >5YZG-W nrPDB Length = 579 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 55/234 (23%), Positives = 95/234 (40%), Gaps = 42/234 (17%) Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 GH K + P LLS S D I LW++ E R + F GH+ V D+ Sbjct: 286 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYG---ERRCL---RTFIGHSKAVRDIC 339 Query: 239 WHLLHESLFGSVADDQKLMIWDT-------RNNNTSKPSHTVDAHTAEVNCLSFNPY--S 289 ++ + F S A D+ L +WDT R N P C+ FNP Sbjct: 340 FNTAG-TQFLSAAYDRYLKLWDTETGQCISRFTNRKVPY-----------CVKFNPDEDK 387 Query: 290 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 + + G +DK + WD+R+ ++ + ++ H + + + N +++S D+ L VW Sbjct: 388 QNLFVAGMSDKKIVQWDIRSGEI-VQEYDRHLGAVNTIVFVDENRRFVSTS-DDKSLRVW 445 Query: 350 DLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIM 403 + D P + +I + + +PN W+ C ++ I+ Sbjct: 446 EW-------------DIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQIL 486 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 34/162 (20%), Positives = 72/162 (44%), Gaps = 17/162 (10%) Query: 194 NGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADD 253 N +S SDD ++ +W+ + P + + I ++ + + L +S+ D Sbjct: 430 NRRFVSTSDDKSLRVWEWD-IPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSM------D 482 Query: 254 QKLMIWDTRNN---NTSK--PSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 308 +++I+ +N N K H V + +V+ F+P +++ +G + + +WD + Sbjct: 483 NQILIFGAQNRFRLNKKKIFKGHMVAGYACQVD---FSPDMSYVI-SGDGNGKLNIWDWK 538 Query: 309 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWD 350 KL F++H W PH + + + G D + +WD Sbjct: 539 TTKL-YSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 1/83 (1%) Query: 268 KPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQV 327 K H HT V+ + P S +L + S D + LW++ + L +F H + + Sbjct: 279 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDI 338 Query: 328 QWSPHNETILASSGTDRRLHVWD 350 ++ L S+ DR L +WD Sbjct: 339 CFNTAGTQFL-SAAYDRYLKLWD 360 >6QDV-o nrPDB Length = 513 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 55/234 (23%), Positives = 95/234 (40%), Gaps = 42/234 (17%) Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 GH K + P LLS S D I LW++ E R + F GH+ V D+ Sbjct: 220 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYG---ERRCL---RTFIGHSKAVRDIC 273 Query: 239 WHLLHESLFGSVADDQKLMIWDT-------RNNNTSKPSHTVDAHTAEVNCLSFNPY--S 289 ++ + F S A D+ L +WDT R N P C+ FNP Sbjct: 274 FNTAG-TQFLSAAYDRYLKLWDTETGQCISRFTNRKVPY-----------CVKFNPDEDK 321 Query: 290 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 + + G +DK + WD+R+ ++ + ++ H + + + N +++S D+ L VW Sbjct: 322 QNLFVAGMSDKKIVQWDIRSGEI-VQEYDRHLGAVNTIVFVDENRRFVSTS-DDKSLRVW 379 Query: 350 DLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIM 403 + D P + +I + + +PN W+ C ++ I+ Sbjct: 380 EW-------------DIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQIL 420 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 34/162 (20%), Positives = 72/162 (44%), Gaps = 17/162 (10%) Query: 194 NGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADD 253 N +S SDD ++ +W+ + P + + I ++ + + L +S+ D Sbjct: 364 NRRFVSTSDDKSLRVWEWD-IPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSM------D 416 Query: 254 QKLMIWDTRNN---NTSK--PSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 308 +++I+ +N N K H V + +V+ F+P +++ +G + + +WD + Sbjct: 417 NQILIFGAQNRFRLNKKKIFKGHMVAGYACQVD---FSPDMSYVI-SGDGNGKLNIWDWK 472 Query: 309 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWD 350 KL F++H W PH + + + G D + +WD Sbjct: 473 TTKL-YSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 513 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 1/83 (1%) Query: 268 KPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQV 327 K H HT V+ + P S +L + S D + LW++ + L +F H + + Sbjct: 213 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDI 272 Query: 328 QWSPHNETILASSGTDRRLHVWD 350 ++ L S+ DR L +WD Sbjct: 273 CFNTAGTQFL-SAAYDRYLKLWD 294 >5OQL-d nrPDB Length = 446 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 45/163 (27%), Positives = 76/163 (46%), Gaps = 11/163 (6%) Query: 187 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 246 LS++ + N + S S I +WD+ EH + + DV ++ + S+ Sbjct: 159 LSFHRSANTFAAS-SGQGCIRIWDL-----EHSTAGQAIQWPSFVDTITDVCFNQVETSV 212 Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 GSVA D+ ++++D R N P H A N + FNP LA S D + ++D Sbjct: 213 IGSVATDRSIILFDLRTN---MPVIKTVLHFA-CNRIVFNPMEAMNLAVASEDHNIYIFD 268 Query: 307 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 RN L+ + H + V++SP E +++ S DR + +W Sbjct: 269 ARNFDKALNIQKGHVAAVMDVEFSPTGEELVSGS-YDRTIRLW 310 Score = 33.5 bits (75), Expect = 0.16, Method: Compositional matrix adjust. Identities = 45/179 (25%), Positives = 71/179 (39%), Gaps = 21/179 (11%) Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEH-RVIDAKNIFTGHTAVVEDV 237 GH + Y + + N + S S D + +WD+ +E RV NI G T + Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTND-- 121 Query: 238 AWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHT----AEVNCLSFNPYSEFIL 293 + L D KL WD + PS+T T LSF+ S Sbjct: 122 ------KKLLSCATDGIKL--WDP----YASPSNTTPIATWQEGGPYTSLSFH-RSANTF 168 Query: 294 ATGSADKTVALWDLR-NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 A S + +WDL + + + S D I V ++ +++ S TDR + ++DL Sbjct: 169 AASSGQGCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDL 227 >5M25-A nrPDB Length = 434 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 60/232 (25%), Positives = 109/232 (46%), Gaps = 26/232 (11%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 + GH+ ++W+ + N L+SASDD T+ +WD+++ GH+ V Sbjct: 183 ISGHKLGISDVAWSSDSN-LLVSASDDKTLKIWDVSSG-------KCLKTLKGHSNYVFC 234 Query: 237 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATG 296 ++ +L S + D+ + IWD + T K T+ AH+ V+ + FN I+++ Sbjct: 235 CNFN-PQSNLIVSGSFDESVRIWDVK---TGKCLKTLPAHSDPVSAVHFNRDGSLIVSS- 289 Query: 297 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGE 356 S D +WD + + + + V++SP+ + ILA++ D L +WD SK G+ Sbjct: 290 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT-LDNTLKLWDYSK-GK 347 Query: 357 EQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 T +F ++FS + WI+ S SEDN++ +W + Sbjct: 348 CLKTYTGHKNEKYCIF---------ANFSVTGGK-WIV-SGSEDNLVYIWNL 388 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 38/137 (27%), Positives = 65/137 (47%), Gaps = 18/137 (13%) Query: 272 TVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP 331 T+ HT V+ + F+P E+ LA+ SADK + +W + K + + HK I V WS Sbjct: 140 TLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWS- 196 Query: 332 HNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEP 391 + +L S+ D+ L +WD+S + L GH+ + ++NP Sbjct: 197 SDSNLLVSASDDKTLKIWDVSS--------------GKCLKTLKGHSNYVFCCNFNPQSN 242 Query: 392 WIICSVSEDNIMQVWQM 408 I+ S S D +++W + Sbjct: 243 LIV-SGSFDESVRIWDV 258 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 13/37 (35%), Positives = 21/37 (56%), Gaps = 1/37 (2%) Query: 370 LLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 L F GHT +S ++PN W + S S D ++++W Sbjct: 137 LKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIW 172 >2H9P-A nrPDB Length = 329 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 68/282 (24%), Positives = 128/282 (45%), Gaps = 37/282 (13%) Query: 127 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 186 H V+ ++ P + ++ S+D L+ + + K E + + GH+ Sbjct: 39 HTKAVSSVKFSPNGEWLASS---SADKLIKIWGAYDGKFEKT--------ISGHKLGISD 87 Query: 187 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 246 ++W+ + N L+SASDD T+ +WD+++ GH+ V ++ +L Sbjct: 88 VAWSSDSN-LLVSASDDKTLKIWDVSSG-------KCLKTLKGHSNYVFCCNFN-PQSNL 138 Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 S + D+ + IWD + T K T+ AH+ V+ + FN I+++ S D +WD Sbjct: 139 IVSGSFDESVRIWDVK---TGKCLKTLPAHSDPVSAVHFNRDGSLIVSS-SYDGLCRIWD 194 Query: 307 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 366 + + + + V++SP+ + ILA++ D L +WD SK G+ T Sbjct: 195 TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT-LDNTLKLWDYSK-GKCLKTYTGHKN 252 Query: 367 PPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 +F ++FS + WI+ S SEDN++ +W + Sbjct: 253 EKYCIF---------ANFSVTGGK-WIV-SGSEDNLVYIWNL 283 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 38/137 (27%), Positives = 65/137 (47%), Gaps = 18/137 (13%) Query: 272 TVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP 331 T+ HT V+ + F+P E+ LA+ SADK + +W + K + + HK I V WS Sbjct: 35 TLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSS 92 Query: 332 HNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEP 391 + +L S+ D+ L +WD+S + L GH+ + ++NP Sbjct: 93 -DSNLLVSASDDKTLKIWDVS--------------SGKCLKTLKGHSNYVFCCNFNPQSN 137 Query: 392 WIICSVSEDNIMQVWQM 408 I+ S S D +++W + Sbjct: 138 LIV-SGSFDESVRIWDV 153 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 13/37 (35%), Positives = 21/37 (56%), Gaps = 1/37 (2%) Query: 370 LLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 L F GHT +S ++PN W + S S D ++++W Sbjct: 32 LKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIW 67 >5GAN-H nrPDB Length = 465 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 93/217 (42%), Gaps = 21/217 (9%) Query: 143 VIATKTPSSDVLVFDYTKHPSKPEPSGECQP-DLRLRGHQKEGYGLSWNPNLNGYLLSAS 201 V+AT + + D+ V + S QP +L H + + W+P+ N ++S + Sbjct: 189 VVATGSWAGDLQVLN----------SQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCA 238 Query: 202 DDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDT 261 +D I + + R++ GH + DV +H GS + D +WD Sbjct: 239 EDGLIKNFQYSNEEGGLRLLGD---LVGHERRISDVKYHP-SGKFIGSASHDMTWRLWDA 294 Query: 262 RNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHK 321 +T + + H V LSF + +G D LWD+R+ K+ + H Sbjct: 295 ---STHQELLLQEGHDKGVFSLSFQCDGSLV-CSGGMDSLSMLWDIRSGS-KVMTLAGHS 349 Query: 322 DEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQ 358 I+ V WSP+ + A+ G D ++VWD+ K E Q Sbjct: 350 KPIYTVAWSPNGYQV-ATGGGDGIINVWDIRKRDEGQ 385 Score = 36.6 bits (83), Expect = 0.025, Method: Compositional matrix adjust. Identities = 34/135 (25%), Positives = 64/135 (47%), Gaps = 15/135 (11%) Query: 175 LRLRGHQKEGYGLSWNPNLNGY-LLSASDDHTICLWDINAT--PKEHRVIDAKNIFTGHT 231 + L GH K Y ++W+P NGY + + D I +WDI + ++++ +NI T Sbjct: 343 MTLAGHSKPIYTVAWSP--NGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVR 400 Query: 232 AVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEF 291 ED L+ S D + ++ +++T ++ HT ++ L + S F Sbjct: 401 FSKEDGGKKLV------SCGYDNLINVY---SSDTWLKMGSLAGHTDKIISLDISNNSHF 451 Query: 292 ILATGSADKTVALWD 306 L +G D+++ LW+ Sbjct: 452 -LVSGGWDRSIKLWN 465 Score = 32.7 bits (73), Expect = 0.28, Method: Compositional matrix adjust. Identities = 28/117 (23%), Positives = 51/117 (43%), Gaps = 11/117 (9%) Query: 290 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 + ++ATGS + + + + L+ +SH +I + W P + + S D + + Sbjct: 187 DMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNF 246 Query: 350 DLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 S E+G LL GH +ISD ++P+ + I S S D ++W Sbjct: 247 QYSN----------EEGGLRLLGDLVGHERRISDVKYHPSGKF-IGSASHDMTWRLW 292 >4N14-A nrPDB Length = 314 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 47/175 (26%), Positives = 75/175 (42%), Gaps = 11/175 (6%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 L GH +E GL W P+ +L S +D+ + +W + P E + + FT H V+ Sbjct: 142 LSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWP--SAPGEGGWVPLQT-FTQHQGAVKA 197 Query: 237 VAWHLLHESLF--GSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILA 294 VAW ++ G D+ + IW N + VDAH+ + L Y E I Sbjct: 198 VAWCPWQSNVLATGGGTSDRHIRIW---NVCSGACLSAVDAHSQVCSILWSPHYKELISG 254 Query: 295 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 G A + +W + K+ + H + + SP T+ AS+ D L +W Sbjct: 255 HGFAQNQLVIWKYPTMA-KVAELKGHTSRVLSLTMSPDGATV-ASAAADETLRLW 307 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 32/117 (27%), Positives = 57/117 (48%), Gaps = 10/117 (8%) Query: 234 VEDVAWHLLHESLFGSVA-DDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI 292 + VAW + E + +V ++ +WD + K + +H+A V LS+N Y I Sbjct: 66 ISSVAW--IKEGNYLAVGTSSAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWNSY---I 117 Query: 293 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 L++GS + D+R + + + H E+ ++W+P LAS G D ++VW Sbjct: 118 LSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW 173 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 54/250 (21%), Positives = 98/250 (39%), Gaps = 50/250 (20%) Query: 196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 255 YL + + LWD+ ++ R+ + T H+A V ++W+ + S + Sbjct: 77 YLAVGTSSAEVQLWDVQ---QQKRLRN----MTSHSARVGSLSWN---SYILSSGSRSGH 126 Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK---L 312 + D R T+ H+ EV L + P LA+G D V +W + + Sbjct: 127 IHHHDVRV--AEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWV 183 Query: 313 KLHSFESHKDEIFQVQWSPHNETILASSG--TDRRLHVWDLSKIGEEQSTEDAEDGP--- 367 L +F H+ + V W P +LA+ G +DR + +W++ G S DA Sbjct: 184 PLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAVDAHSQVCSI 242 Query: 368 ------PELLFIHG---------------------GHTAKISDFSWNPNEPWIICSVSED 400 EL+ HG GHT+++ + +P+ + S + D Sbjct: 243 LWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVASAAAD 301 Query: 401 NIMQVWQMAE 410 +++W+ E Sbjct: 302 ETLRLWRCFE 311 >5OPT-p nrPDB Length = 318 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 62/244 (25%), Positives = 109/244 (44%), Gaps = 31/244 (12%) Query: 176 RLRGHQKEGYGLSWNPNLNGYL--LSASDDHTICLW----DINATPKEHRVIDAKNIFTG 229 +L+GH+ L+ Y+ +S S D+T+ W D N+ E+ + + G Sbjct: 8 QLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERR--LEG 65 Query: 230 HTAVVEDVAWHLLHESLFGSVAD-DQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPY 288 H+A V DVA L + F A D L +W N T H HT +V ++F+P Sbjct: 66 HSAFVSDVA--LSNNGDFAVSASWDHSLRLW---NLQTGVCQHKFLGHTKDVLSVTFSPD 120 Query: 289 SEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET-ILASSGTDRRLH 347 + I+ +G D + +W+++ L +H D + V++SP ET ++ S G D + Sbjct: 121 NRQIV-SGGRDNALRVWNVKGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVK 179 Query: 348 VWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 VWD++ LL GHT I+ + +P+ + S +D + ++W Sbjct: 180 VWDIAS--------------GRLLTDLKGHTNYITSVTVSPDGS-LCASSDKDGVARLWD 224 Query: 408 MAEN 411 + + Sbjct: 225 LTKG 228 >6HHQ-h nrPDB Length = 319 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 56/225 (24%), Positives = 102/225 (45%), Gaps = 34/225 (15%) Query: 191 PNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFG-S 249 PNL LLSAS D T+ W + ++ V F GH+ +V+D L + + S Sbjct: 30 PNL---LLSASRDKTLISWKLTGDDQKFGV--PVRSFKGHSHIVQDCT--LTADGAYALS 82 Query: 250 VADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 309 + D+ L +WD T + H ++V + + + I+ +GS DKT+ +W ++ Sbjct: 83 ASWDKTLRLWDVA---TGETYQRFVGHKSDVMSVDIDKKASMII-SGSRDKTIKVWTIKG 138 Query: 310 LKLKLHSFESHKDEIFQVQWSPH-----NETILASSGTDRRLHVWDLSKIGEEQSTEDAE 364 L + H D + QV+ P+ + + S+G D+ + W+L++ E Sbjct: 139 QCLA--TLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEAD----- 191 Query: 365 DGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMA 409 FI GH + I+ + +P+ +I S +D + +W +A Sbjct: 192 -------FI--GHNSNINTLTASPDGT-LIASAGKDGEIMLWNLA 226 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 52/211 (24%), Positives = 87/211 (41%), Gaps = 36/211 (17%) Query: 194 NGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADD 253 Y LSAS D T+ LWD+ R F GH + V V S+ S + D Sbjct: 77 GAYALSASWDKTLRLWDVATGETYQR-------FVGHKSDVMSVDID-KKASMIISGSRD 128 Query: 254 QKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPY------SEFILATGSADKTVALWDL 307 + + +W + + T+ H V+ + P S I++ G+ DK V W+L Sbjct: 129 KTIKVWTIKGQCLA----TLLGHNDWVSQVRVVPNEKADDDSVTIISAGN-DKMVKAWNL 183 Query: 308 RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGP 367 +++ F H I + SP + T++AS+G D + +W+L+ + T A+D Sbjct: 184 NQFQIE-ADFIGHNSNINTLTASP-DGTLIASAGKDGEIMLWNLAA-KKAMYTLSAQDEV 240 Query: 368 PELLFIHGGHTAKISDFSWNPNEPWIICSVS 398 L F +PN W+ + + Sbjct: 241 FSLAF--------------SPNRYWLAAATA 257 Score = 28.5 bits (62), Expect = 5.6, Method: Compositional matrix adjust. Identities = 31/141 (21%), Positives = 57/141 (40%), Gaps = 20/141 (14%) Query: 272 TVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL----RNLKLKLHSFESHKDEIFQV 327 T++ H V L+ + +L + S DKT+ W L + + + SF+ H + Sbjct: 12 TLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDC 71 Query: 328 QWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWN 387 + L++S D+ L +WD++ G F+ GH + + + Sbjct: 72 TLTADGAYALSASW-DKTLRLWDVAT------------GETYQRFV--GHKSDVMSVDID 116 Query: 388 PNEPWIICSVSEDNIMQVWQM 408 II S S D ++VW + Sbjct: 117 KKASMII-SGSRDKTIKVWTI 136 >4AEZ-A nrPDB Length = 401 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 54/190 (28%), Positives = 88/190 (46%), Gaps = 19/190 (10%) Query: 170 ECQPDLR-LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFT 228 E Q LR + GHQ LSWN ++ L S S I D+ H++ Sbjct: 164 ESQTKLRTMAGHQARVGCLSWNRHV---LSSGSRSGAIHHHDVRIA--NHQI----GTLQ 214 Query: 229 GHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPY 288 GH++ V +AW L S +D + IWD R +S P T H A V +++ P+ Sbjct: 215 GHSSEVCGLAWRSDGLQL-ASGGNDNVVQIWDAR---SSIPKFTKTNHNAAVKAVAWCPW 270 Query: 289 SEFILATGSA--DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG-TDRR 345 +LATG DK + W+ ++++ ++ ++ + WSPH++ I+++ G D Sbjct: 271 QSNLLATGGGTMDKQIHFWNAAT-GARVNTVDA-GSQVTSLIWSPHSKEIMSTHGFPDNN 328 Query: 346 LHVWDLSKIG 355 L +W S G Sbjct: 329 LSIWSYSSSG 338 >1VYH-C nrPDB Length = 410 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 46/158 (29%), Positives = 70/158 (44%), Gaps = 33/158 (20%) Query: 170 ECQPDLRLRGHQKEGYGLSWNPNLN-------------------GYLLSASDDHTICLWD 210 EC+ +LR H E +SW P + +LLS S D TI +WD Sbjct: 267 ECKAELREHRHVVEC--ISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWD 324 Query: 211 INATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPS 270 ++ GH V V +H + + S ADD+ L +WD +N K Sbjct: 325 VSTGM-------CLMTLVGHDNWVRGVLFHSGGKFIL-SCADDKTLRVWDYKNKRCMK-- 374 Query: 271 HTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 308 T++AH V L F+ + +++ TGS D+TV +W+ R Sbjct: 375 -TLNAHEHFVTSLDFHKTAPYVV-TGSVDQTVKVWECR 410 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 45/175 (25%), Positives = 87/175 (49%), Gaps = 19/175 (10%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 L GH+ + ++P + ++SAS+D TI +WD + D + GHT V+D Sbjct: 104 LSGHRSPVTRVIFHPVFS-VMVSASEDATIKVWD-------YETGDFERTLKGHTDSVQD 155 Query: 237 VAWHLLHES-LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILAT 295 +++ H L S + D + +WD + + H H V+ +S P + I++ Sbjct: 156 ISFD--HSGKLLASCSADMTIKLWDFQGFECIRTMH---GHDHNVSSVSIMPNGDHIVS- 209 Query: 296 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE-TILASSGTDRRLHVW 349 S DKT+ +W+++ + +F H++ + V+ P+ + T++AS D+ + VW Sbjct: 210 ASRDKTIKMWEVQT-GYCVKTFTGHREWVRMVR--PNQDGTLIASCSNDQTVRVW 261 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 34/128 (26%), Positives = 67/128 (52%), Gaps = 7/128 (5%) Query: 224 KNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCL 283 K +GH + V V +H + S+ S ++D + +WD + + T+ HT V + Sbjct: 101 KYALSGHRSPVTRVIFHPVF-SVMVSASEDATIKVWDYETGDFER---TLKGHTDSVQDI 156 Query: 284 SFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTD 343 SF+ +S +LA+ SAD T+ LWD + + + + H + V P+ + I+++S D Sbjct: 157 SFD-HSGKLLASCSADMTIKLWDFQGFEC-IRTMHGHDHNVSSVSIMPNGDHIVSAS-RD 213 Query: 344 RRLHVWDL 351 + + +W++ Sbjct: 214 KTIKMWEV 221 >5L9T-R nrPDB Length = 493 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 56/256 (21%), Positives = 105/256 (41%), Gaps = 29/256 (11%) Query: 104 NEKGEFGGFGSVCGKIEI-----EIKINH-EGEVNRARYMPQNACVIATKTPSSDVLVFD 157 +E+G G+ G ++I K++ EG R + NA +++ + +L D Sbjct: 238 SERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRD 297 Query: 158 YTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKE 217 P Q + RL+GH++E GL W+ + + L S +D+ + +W+ Sbjct: 298 IRTPP--------LQSERRLQGHRQEVCGLKWSTD-HQLLASGGNDNKLLVWN------- 341 Query: 218 HRVIDAKNIFTGHTAVVEDVAWHLLHESLF--GSVADDQKLMIWDTRNNNTSKPSHTVDA 275 H + +T H A V+ +AW L G D+ + W+T T +P +D Sbjct: 342 HSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTL---TGQPLQCIDT 398 Query: 276 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET 335 + N +E + G + + +W +L ++ H + + SP E Sbjct: 399 GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLT-QVAKLTGHSYRVLYLAMSPDGEA 457 Query: 336 ILASSGTDRRLHVWDL 351 I+ +G D L W++ Sbjct: 458 IVTGAG-DETLRFWNV 472 >6N9G-C nrPDB Length = 353 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 63/215 (29%), Positives = 96/215 (44%), Gaps = 35/215 (16%) Query: 197 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES----LFGSVAD 252 +L+AS D T LWD+ + F GH A DV L S F S Sbjct: 168 ILTASGDGTCALWDVESGQLLQS-------FHGHGA---DVLCLDLAPSETGNTFVSGGC 217 Query: 253 DQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR-NLK 311 D+K M+WD R+ + T H ++VN + + P + A+GS D T L+DLR + + Sbjct: 218 DKKAMVWDMRSGQCVQAFET---HESDVNSVRYYPSGD-AFASGSDDATCRLYDLRADRE 273 Query: 312 LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELL 371 + ++S ES V +S + A D ++VWD+ K G S +L Sbjct: 274 VAIYSKESIIFGASSVDFSLSGRLLFAGY-NDYTINVWDVLK-GSRVS----------IL 321 Query: 372 FIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 F GH ++S +P+ CS S D+ ++VW Sbjct: 322 F---GHENRVSTLRVSPDGT-AFCSGSWDHTLRVW 352 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 46/184 (25%), Positives = 75/184 (40%), Gaps = 25/184 (13%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 L+GH + + W + ++S+S D + +WD T KEH AV Sbjct: 59 LKGHGNKVLCMDWCKDKR-RIVSSSQDGKVIVWDSFTTNKEH-------------AVTMP 104 Query: 237 VAWHLLHE-----SLFGSVADDQKLMIWDT---RNNNTSKPSHTVDAHTAEVNCLSFNPY 288 W + D K ++ +N N + +V HT ++ SF Sbjct: 105 CTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTN- 163 Query: 289 SEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP-HNETILASSGTDRRLH 347 S+ + T S D T ALWD+ + +L L SF H ++ + +P S G D++ Sbjct: 164 SDMQILTASGDGTCALWDVESGQL-LQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAM 222 Query: 348 VWDL 351 VWD+ Sbjct: 223 VWDM 226 >5WYJ-BC nrPDB Length = 817 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 69/300 (23%), Positives = 129/300 (43%), Gaps = 52/300 (17%) Query: 126 NHEGEVNRARYM-PQ-NACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRL-RGHQK 182 NH G + RY+ P+ N +AT +PS ++ P P D+ + GH+ Sbjct: 336 NH-GIIADMRYVGPELNKLALATNSPSLRIIPV-----PDLSGPEASLPLDVEIYEGHED 389 Query: 183 EGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLL 242 L + ++ +AS D+T +W N + D + GH+A V V + Sbjct: 390 LLNSLDATED-GLWIATASKDNTAIVWRYNENSCK---FDIYAKYIGHSAAVTAVGLPNI 445 Query: 243 ----HESLFGSVADDQKLMIWDTRNNNTSKPSHTVD------------AHTAEVNCLSFN 286 + + ++D + W KP+ ++D AH ++N LS + Sbjct: 446 VSKGYPEFLLTASNDLTIKKWII-----PKPTASMDVQIIKVSEYTRHAHEKDINALSVS 500 Query: 287 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 346 P ++ I AT S DKT +W+L N +L+ + +HK ++ V + +++ +LA+S D+ + Sbjct: 501 P-NDSIFATASYDKTCKIWNLENGELE-ATLANHKRGLWDVSFCQYDK-LLATSSGDKTV 557 Query: 347 HVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 +W L ++ E GHT + S+ + +I S D ++++W Sbjct: 558 KIWSLDTFSVMKTLE--------------GHTNAVQRCSFINKQKQLI-SCGADGLIKIW 602 Score = 36.2 bits (82), Expect = 0.029, Method: Compositional matrix adjust. Identities = 26/96 (27%), Positives = 44/96 (45%), Gaps = 15/96 (15%) Query: 261 TRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESH 320 R+ S PS+ +DA + +LA G D ++ + D+ N + HSF+ H Sbjct: 96 VRSMKISSPSYILDADSTST-----------LLAVGGTDGSIIVVDIENGYIT-HSFKGH 143 Query: 321 KDEIFQVQWSPHNET---ILASSGTDRRLHVWDLSK 353 I +++ + +LAS T+ + VWDL K Sbjct: 144 GGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVK 179 Score = 34.7 bits (78), Expect = 0.092, Method: Compositional matrix adjust. Identities = 42/188 (22%), Positives = 80/188 (42%), Gaps = 27/188 (14%) Query: 197 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 256 L ++S D T+ +W ++ GHT V+ ++ + L S D + Sbjct: 548 LATSSGDKTVKIWSLDT-------FSVMKTLEGHTNAVQRCSFINKQKQLI-SCGADGLI 599 Query: 257 MIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD---------- 306 IWD + K T+D H + LS + I+ + AD W Sbjct: 600 KIWDCSSGECLK---TLDGHNNRLWALSTMNDGDMIV-SADADGVFQFWKDCTEQEIEEE 655 Query: 307 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSK--IGEEQSTEDAE 364 KL++ +S ++ + + W+ N +LA + D + ++++ K +GE +S +D E Sbjct: 656 QEKAKLQVEQEQSLQNYMSKGDWT--NAFLLAMT-LDHPMRLFNVLKRALGESRSRQDTE 712 Query: 365 DGPPELLF 372 +G E++F Sbjct: 713 EGKIEVIF 720 >5OQL-L nrPDB Length = 557 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 35/105 (33%), Positives = 53/105 (50%), Gaps = 6/105 (5%) Query: 239 WHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS--EFILATG 296 W + S +DD+ + +WD +N+ P+ HT V C +F P S +L +G Sbjct: 152 WSPTELTTLMSCSDDKTVRLWDLPSND---PTRLFTGHTDYVRCGAFMPGSANSNLLVSG 208 Query: 297 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG 341 S D+TV +WD R + +F+ H D I V P T+LA+SG Sbjct: 209 SYDETVRVWDARAPGGAVMTFK-HADPIEDVLPLPSGTTLLAASG 252 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 9/85 (10%) Query: 180 HQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW 239 H++ + W+P L+S SDD T+ LWD+ + D +FTGHT V A+ Sbjct: 143 HKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSN-------DPTRLFTGHTDYVRCGAF 195 Query: 240 H--LLHESLFGSVADDQKLMIWDTR 262 + +L S + D+ + +WD R Sbjct: 196 MPGSANSNLLVSGSYDETVRVWDAR 220 Score = 35.0 bits (79), Expect = 0.062, Method: Compositional matrix adjust. Identities = 40/182 (21%), Positives = 72/182 (39%), Gaps = 22/182 (12%) Query: 229 GHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPY 288 G TA+V + +V ++ I+ R +P T+ +E +C P Sbjct: 54 GTTALVSSSLVAAAKTNDLFAVTAGPRVEIFSIRKR---EPLKTIGRFDSEAHCGEIRPD 110 Query: 289 SEFILATGSADKTVALWDLR--NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 346 ++A G + ++D+ + L ++ HK ++ +WSP T L S D+ + Sbjct: 111 GRVLVA-GEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTV 169 Query: 347 HVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEP--WIICSVSEDNIMQ 404 +WDL P LF GHT + ++ P ++ S S D ++ Sbjct: 170 RLWDL------------PSNDPTRLFT--GHTDYVRCGAFMPGSANSNLLVSGSYDETVR 215 Query: 405 VW 406 VW Sbjct: 216 VW 217 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 35/130 (26%), Positives = 51/130 (39%), Gaps = 5/130 (3%) Query: 252 DDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL-RNL 310 D ++ ++D + T H V ++P L + S DKTV LWDL N Sbjct: 119 DTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSND 178 Query: 311 KLKLHSFESHKDEIFQVQWSP--HNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPP 368 +L F H D + + P N +L S D + VWD G T D Sbjct: 179 PTRL--FTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIE 236 Query: 369 ELLFIHGGHT 378 ++L + G T Sbjct: 237 DVLPLPSGTT 246 >5FA5-B nrPDB Length = 367 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 44/169 (26%), Positives = 81/169 (47%), Gaps = 10/169 (5%) Query: 178 RGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDV 237 R H + ++ +P+ + LS S+D+ I LWD PK I + + + Sbjct: 189 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRC-PKPASQIGC----SAPGYLPTSL 243 Query: 238 AWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGS 297 AWH +F ++ + + DT++ + S H+ V L F+P+S LA+ S Sbjct: 244 AWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAV---HSQCVTGLVFSPHSVPFLASLS 300 Query: 298 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 346 D ++A+ D +L +L ++H+D + WSP N ++L + G D ++ Sbjct: 301 EDCSLAVLD-SSLS-ELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 50/193 (25%), Positives = 83/193 (43%), Gaps = 28/193 (14%) Query: 198 LSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLM 257 +S S D I +WD+ + V+ + + H A V VA +S+F S ++D +++ Sbjct: 166 VSGSKDICIKVWDL----AQQVVLSS---YRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 218 Query: 258 IWDTRNNNTSKPSHTVDAHTAEV--NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 315 +WDTR KP+ + L+++P + G + TV+L D ++ L Sbjct: 219 LWDTR---CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 275 Query: 316 SFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHG 375 S H + + +SPH+ LAS D L V D S + E LF Sbjct: 276 S-AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSE--------------LFRSQ 319 Query: 376 GHTAKISDFSWNP 388 H + D +W+P Sbjct: 320 AHRDFVRDATWSP 332 Score = 35.8 bits (81), Expect = 0.035, Method: Compositional matrix adjust. Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 7/115 (6%) Query: 197 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 256 +L ASD + LW+++ + +I +K H +V V+ L + S + D + Sbjct: 119 ILVASDSGAVELWELD---ENETLIVSKFCKYEHDDIVSTVS-VLSSGTQAVSGSKDICI 174 Query: 257 MIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK 311 +WD + AH A+V C++ +P+ + + + S D + LWD R K Sbjct: 175 KVWDLAQQVVLS---SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 226 >5OQL-J nrPDB Length = 912 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 49/209 (23%), Positives = 78/209 (37%), Gaps = 51/209 (24%) Query: 162 PSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVI 221 P + + G+ LR H K+ L +PN SAS D T+ +WD+ + Sbjct: 525 PRQLQKGGKLTSSLRRLAHDKDINALDISPN-GKLFASASQDKTVKIWDVEK-------L 576 Query: 222 DAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVN 281 + + I GH K +W R + P + V+ Sbjct: 577 EVQGILRGH------------------------KRGVWTVRFAPLNTP--VIQGEQGSVS 610 Query: 282 CLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQW--------SPHN 333 ++ TGS DKT+ LW+L + + +FE H + +V W Sbjct: 611 -------GRGVVLTGSGDKTIKLWNLSDYTC-IRTFEGHSHNVLKVVWLHISRDDSITKT 662 Query: 334 ETILASSGTDRRLHVWDLSKIGEEQSTED 362 + AS+G D + VWD + GE + T D Sbjct: 663 KVQFASAGADTLVKVWD-ANTGETECTLD 690 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 57/258 (22%), Positives = 106/258 (41%), Gaps = 49/258 (18%) Query: 136 YMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPD-------LRLRGHQKEGYGLS 188 Y+ + ++A T S D+ + + E + EC+ L+GH E +S Sbjct: 381 YILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGH--EDIVMS 438 Query: 189 WNPNLNGY-LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLL----- 242 + + +G+ + S S D+T LW ++ + +FTGH V VA + Sbjct: 439 LDVDWSGHWIASGSKDNTARLWRVDPANNSY---TCYAVFTGHLESVGAVALPKVVPPAN 495 Query: 243 HESLFGSVADDQKLMIWDTRNNNTSK--------------PSHTVDAHTAEVNCLSFNPY 288 E+ + +I +++ K S AH ++N L +P Sbjct: 496 SEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPN 555 Query: 289 SEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE-------------- 334 + + A+ S DKTV +WD+ L+++ HK ++ V+++P N Sbjct: 556 GK-LFASASQDKTVKIWDVEKLEVQ-GILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRG 613 Query: 335 TILASSGTDRRLHVWDLS 352 +L SG D+ + +W+LS Sbjct: 614 VVLTGSG-DKTIKLWNLS 630 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 30/116 (25%), Positives = 54/116 (46%), Gaps = 7/116 (6%) Query: 253 DQKLMIWDTRNNNTS----KPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 308 D ++ I+D T+ P +AH + V C++++P + L +GS DKT+ LW R Sbjct: 204 DGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSP-EQHALLSGSRDKTMTLWLWR 262 Query: 309 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAE 364 + + H E+ + + + S+GT L +WD + E +DA+ Sbjct: 263 DGIWQGTPMLRH--ELLESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAK 316 >3JB9-L nrPDB Length = 340 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 60/270 (22%), Positives = 104/270 (38%), Gaps = 51/270 (18%) Query: 173 PDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVI----------- 221 P+L++ GH E ++P+ Y S D I LW++ K + V+ Sbjct: 42 PNLQMFGHTAEVLVARFDPS-GSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQ 100 Query: 222 ---DAKNIFT----------------------GHTAVVEDVAWHLLHESLFGSVADDQKL 256 D++ ++ GH VV + + L SV+DD + Sbjct: 101 WSRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTM 160 Query: 257 MIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 316 +WD+R+ + K TA ++ FI G D + +WDLRN H Sbjct: 161 KVWDSRSKDCIKTIEEKYPLTAV--AIAQQGTQVFI---GGIDGAIKIWDLRNNHCS-HV 214 Query: 317 FESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGG 376 + HKD I + S ++L++S D + ++D+ Q +G IH G Sbjct: 215 LKGHKDIITSLAISKDGSSLLSNS-MDNTVRIFDVKPFASAQRQLQIFEGA-----IH-G 267 Query: 377 HTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 + +W+ N ++ S+ N+ VW Sbjct: 268 QEHNLLGVAWSRNSRFVGAGSSDKNVY-VW 296 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 37/145 (25%), Positives = 60/145 (41%), Gaps = 16/145 (11%) Query: 262 RNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHK 321 R ++ + P+ + HTAEV F+P + A+G D+ + LW++ K Sbjct: 35 RTSDLNVPNLQMFGHTAEVLVARFDPSGSY-FASGGMDRQILLWNVFGDVKNYGVLNGCK 93 Query: 322 DEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKI 381 I +QWS + + SS +D L W DA G + H GH + Sbjct: 94 GAITDLQWSRDSRVVYCSS-SDTHLMSW------------DAVSGQK--IRKHKGHAGVV 138 Query: 382 SDFSWNPNEPWIICSVSEDNIMQVW 406 + ++ SVS+D M+VW Sbjct: 139 NALDVLKVGSELLTSVSDDCTMKVW 163 >5A9Q-0 nrPDB Length = 380 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 72/300 (24%), Positives = 119/300 (39%), Gaps = 39/300 (13%) Query: 97 FDGSHYDNEK--------GEFGGF---GSVCGKIEIEIKINHEGEVNRARYMPQNACVIA 145 F +DNE+ G+FG G G ++ I H G+V ++ Q V A Sbjct: 32 FATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQERIVAA 91 Query: 146 TKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG---LSWNPNL-----NGYL 197 + T V + HP+ S Q H G G S P N + Sbjct: 92 SSTGCVTV----FLHHPNNQTLSVNQQ---WTTAHYHTGPGSPSYSSAPCTGVVCNNPEI 144 Query: 198 LSASDDHTICLWDINATPKEH-RVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 256 ++ +D I L+ A KE R ID + T H L +V +L Sbjct: 145 VTVGEDGRINLF--RADHKEAVRTIDNADSSTLHAVT-------FLRTPEILTVNSIGQL 195 Query: 257 MIWDTRNNNTSKPSH--TVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL 314 IWD R ++PS ++ ++C+ +P + ++ATG D +++WD+R + + Sbjct: 196 KIWDFRQQG-NEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPV 254 Query: 315 HSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIH 374 ++H+ E+++V + P N L + D L WD S E+S+ + G H Sbjct: 255 SLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSH 314 Score = 30.0 bits (66), Expect = 2.0, Method: Compositional matrix adjust. Identities = 27/114 (23%), Positives = 51/114 (44%), Gaps = 16/114 (14%) Query: 302 VALWDLR---NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQ 358 + +WD R N ++ S + + V P+ + ++A+ G D L +WD+ Q Sbjct: 195 LKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDV-----RQ 249 Query: 359 STEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENV 412 T P LL H A++ + ++P+ P + + SED + W + +V Sbjct: 250 GTM-----PVSLL---KAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDV 295 >5WLC-LU nrPDB Length = 489 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 45/203 (22%), Positives = 77/203 (37%), Gaps = 54/203 (26%) Query: 196 YLLSASDDHTICLWDINA--------------TPKEH--RVIDAKNIFTG---------- 229 ++LS SDD T+ LW IN T +E R D ++ F G Sbjct: 135 FMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQGIDSHRENSTF 194 Query: 230 -------------HTAVVEDVAW----------HLLHESLFGSVADDQKLMIWDTRNNNT 266 V D++W + + S D ++++D R N+ Sbjct: 195 ATGGAKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNS- 253 Query: 267 SKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQ 326 P+ + T N + +NP F T + D +D+RNL L+ F+ H + Sbjct: 254 --PTQKI-VQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMD 310 Query: 327 VQWSPHNETILASSGTDRRLHVW 349 V +SP + I+ S D+ + ++ Sbjct: 311 VDFSPTGDEIVTGS-YDKSIRIY 332 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 47/217 (21%), Positives = 88/217 (40%), Gaps = 17/217 (7%) Query: 187 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 246 L +N N L S D++I L+D+ +++ T + W+ + Sbjct: 225 LKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIV--------QTMRTNAICWNPMEAFN 276 Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 F + +D +D R N S+ + H + V + F+P + I+ TGS DK++ ++ Sbjct: 277 FVTANEDHNAYYYDMR--NLSRSLNVFKDHVSAVMDVDFSPTGDEIV-TGSYDKSIRIYK 333 Query: 307 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASS--GTDR--RLHVWDLSKIGEEQSTED 362 + + +FQV++S ++ I++ S G R R W+ S + + Sbjct: 334 TNHGHSREIYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLWRSKAWERSNVKTTREKNK 393 Query: 363 AEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSE 399 E E L H +I S + + P +I E Sbjct: 394 LE--YDEKLKERFRHMPEIKRISRHRHVPQVIKKAQE 428 >2PM9-A nrPDB Length = 416 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 57/268 (21%), Positives = 109/268 (40%), Gaps = 33/268 (12%) Query: 176 RLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINA---TPKEHRVIDAKNIFTGHTA 232 R H + +N + L S ++ I +WD+N +P + + + Sbjct: 108 RFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDE 167 Query: 233 VVEDVAWHLLHESLFGSVADDQKLMIWDTRNN------NTSKPSHTVDAHTAEVNCLSFN 286 V+ +AW+ +F S IWD + + + P+ + +++ + ++ Sbjct: 168 VIS-LAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQ---QLSVVEWH 223 Query: 287 PYSEFILATGSA---DKTVALWDLRNLKLKLHSF-ESHKDEIFQVQWSPHNETILASSGT 342 P + +AT + D ++ +WDLRN L + + H+ I + W +E +L SSG Sbjct: 224 PKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGR 283 Query: 343 DRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNI 402 D + +W+ +S E P G+ + F+ P P + S DN Sbjct: 284 DNTVLLWN------PESAEQLSQFPAR------GNWCFKTKFA--PEAPDLFACASFDNK 329 Query: 403 MQV--WQMAENVYNDEEPEIPASELETN 428 ++V Q N +++E E E ET+ Sbjct: 330 IEVQTLQNLTNTLDEQETETKQQESETD 357 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 35/164 (21%), Positives = 69/164 (42%), Gaps = 23/164 (14%) Query: 201 SDDHTICLWDINATPKEHRV----IDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 256 S D ++ LW + A E + +D+K D+ W ++ + G++ D+ L Sbjct: 42 STDSSLELWSLLAADSEKPIASLQVDSK---------FNDLDWSHNNKIIAGAL-DNGSL 91 Query: 257 MIWDTRN-NNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 315 ++ T NN H++ V + FN + +LA+G + + +WD+ Sbjct: 92 ELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPS 151 Query: 316 SFE--------SHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 ++ S DE+ + W+ + AS+G+ +WDL Sbjct: 152 NYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDL 195 Score = 33.5 bits (75), Expect = 0.16, Method: Compositional matrix adjust. Identities = 18/95 (18%), Positives = 39/95 (41%), Gaps = 5/95 (5%) Query: 314 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFI 373 + F +H + V+++ + +LAS G + + +WD++K TE + P Sbjct: 106 MARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKC-----TESPSNYTPLTPGQ 160 Query: 374 HGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 ++ +WN + + S N +W + Sbjct: 161 SMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDL 195 Score = 28.9 bits (63), Expect = 4.0, Method: Compositional matrix adjust. Identities = 22/84 (26%), Positives = 42/84 (50%), Gaps = 11/84 (13%) Query: 130 EVNRARYMPQNACVIATKTPSSD---VLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 186 +++ + P+N+ +AT T S + +L++D ++ + P + +GHQK Sbjct: 216 QLSVVEWHPKNSTRVATATGSDNDPSILIWDL-RNANTPLQTLN-------QGHQKGILS 267 Query: 187 LSWNPNLNGYLLSASDDHTICLWD 210 L W LLS+ D+T+ LW+ Sbjct: 268 LDWCHQDEHLLLSSGRDNTVLLWN 291 >2YNP-A nrPDB Length = 604 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 46/187 (24%), Positives = 81/187 (43%), Gaps = 36/187 (19%) Query: 251 ADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 310 +DD ++ ++ N NT + +AH + ++ +P ++L+ GS D TV LW+ N Sbjct: 74 SDDFRIRVF---NYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLS-GSDDLTVKLWNWENN 129 Query: 311 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSK--------IGEEQSTED 362 +FE H+ + V ++P + + AS DR + VW L + G+E+ Sbjct: 130 WALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNY 189 Query: 363 AEDGP----PELLFIHGGHTAKISDFS-------------------WNPNEPWIICSVSE 399 + P P ++ T KI D+ ++P P II S SE Sbjct: 190 VDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLP-IIISGSE 248 Query: 400 DNIMQVW 406 D +++W Sbjct: 249 DGTLKIW 255 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 43/166 (25%), Positives = 71/166 (42%), Gaps = 13/166 (7%) Query: 196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 255 Y+LS SDD T+ LW+ + F GH V VA++ S F S D+ Sbjct: 111 YVLSGSDDLTVKLWNWENNWA------LEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRT 164 Query: 256 LMIWDTRNNNTSKPSHTV-DAHTAEVNCLSFNPYSEF-ILATGSADKTVALWDLRNLKLK 313 + +W S P+ T+ VN + + P + + T S D T+ +WD + K Sbjct: 165 VKVWSL---GQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQT-KSC 220 Query: 314 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQS 359 + + E H + + P I++ S D L +W+ S E++ Sbjct: 221 VATLEGHMSNVSFAVFHPTLPIIISGS-EDGTLKIWNSSTYKVEKT 265 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 33/127 (25%), Positives = 57/127 (44%), Gaps = 25/127 (19%) Query: 169 GECQPDLRLRGHQKEG------YGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVID 222 G+ P+ L Q+ G Y L P Y+++ASDD TI +WD ++ Sbjct: 171 GQSTPNFTLTTGQERGVNYVDYYPLPDKP----YMITASDDLTIKIWD-------YQTKS 219 Query: 223 AKNIFTGHTAVVEDVAWHLLHESL--FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEV 280 GH + +V++ + H +L S ++D L IW N++T K T++ Sbjct: 220 CVATLEGH---MSNVSFAVFHPTLPIIISGSEDGTLKIW---NSSTYKVEKTLNVGLERS 273 Query: 281 NCLSFNP 287 C++ +P Sbjct: 274 WCIATHP 280 Score = 28.5 bits (62), Expect = 5.2, Method: Compositional matrix adjust. Identities = 28/123 (22%), Positives = 52/123 (42%), Gaps = 17/123 (13%) Query: 293 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL- 351 + GS D + +++ N K+ FE+H D I + P +L+ S D + +W+ Sbjct: 70 IIVGSDDFRIRVFNY-NTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGS-DDLTVKLWNWE 127 Query: 352 SKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 + EQ+ E GH + ++NP +P S D ++VW + ++ Sbjct: 128 NNWALEQTFE--------------GHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQS 173 Query: 412 VYN 414 N Sbjct: 174 TPN 176 >3MKQ-A nrPDB Length = 814 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 16/156 (10%) Query: 251 ADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 310 +DD ++ ++ N NT + +AH + ++ +P ++L +GS D TV LW+ N Sbjct: 74 SDDFRIRVF---NYNTGEKVVDFEAHPDYIRSIAVHPTKPYVL-SGSDDLTVKLWNWENN 129 Query: 311 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPEL 370 +FE H+ + V ++P + + AS DR + VW L QST P Sbjct: 130 WALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLG-----QST------PNFT 178 Query: 371 LFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 L D+ P++P++I + S+D +++W Sbjct: 179 LTTGQERGVNYVDYYPLPDKPYMITA-SDDLTIKIW 213 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 43/166 (25%), Positives = 71/166 (42%), Gaps = 13/166 (7%) Query: 196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 255 Y+LS SDD T+ LW+ + F GH V VA++ S F S D+ Sbjct: 111 YVLSGSDDLTVKLWNWENNWALEQT------FEGHEHFVMCVAFNPKDPSTFASGCLDRT 164 Query: 256 LMIWDTRNNNTSKPSHTV-DAHTAEVNCLSFNPYSEF-ILATGSADKTVALWDLRNLKLK 313 + +W S P+ T+ VN + + P + + T S D T+ +WD + K Sbjct: 165 VKVWSL---GQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQT-KSC 220 Query: 314 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQS 359 + + E H + + P I++ S D L +W+ S E++ Sbjct: 221 VATLEGHMSNVSFAVFHPTLPIIISGS-EDGTLKIWNSSTYKVEKT 265 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 33/127 (25%), Positives = 57/127 (44%), Gaps = 25/127 (19%) Query: 169 GECQPDLRLRGHQKEG------YGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVID 222 G+ P+ L Q+ G Y L P Y+++ASDD TI +WD ++ Sbjct: 171 GQSTPNFTLTTGQERGVNYVDYYPLPDKP----YMITASDDLTIKIWD-------YQTKS 219 Query: 223 AKNIFTGHTAVVEDVAWHLLHESL--FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEV 280 GH + +V++ + H +L S ++D L IW N++T K T++ Sbjct: 220 CVATLEGH---MSNVSFAVFHPTLPIIISGSEDGTLKIW---NSSTYKVEKTLNVGLERS 273 Query: 281 NCLSFNP 287 C++ +P Sbjct: 274 WCIATHP 280 Score = 28.9 bits (63), Expect = 4.7, Method: Compositional matrix adjust. Identities = 40/195 (20%), Positives = 78/195 (40%), Gaps = 22/195 (11%) Query: 221 IDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEV 280 +D K F+ + V+ + +H + ++ ++ IW N T ++ V Sbjct: 3 LDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSG-RVEIW---NYETQVEVRSIQVTETPV 58 Query: 281 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 340 F +I+ GS D + +++ N K+ FE+H D I + P +L+ S Sbjct: 59 RAGKFIARKNWIIV-GSDDFRIRVFNY-NTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGS 116 Query: 341 GTDRRLHVWDL-SKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSE 399 D + +W+ + EQ+ E GH + ++NP +P S Sbjct: 117 -DDLTVKLWNWENNWALEQTFE--------------GHEHFVMCVAFNPKDPSTFASGCL 161 Query: 400 DNIMQVWQMAENVYN 414 D ++VW + ++ N Sbjct: 162 DRTVKVWSLGQSTPN 176 >1NR0-A nrPDB Length = 611 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 51/226 (22%), Positives = 106/226 (46%), Gaps = 36/226 (15%) Query: 194 NGYLLSASDDH-TICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVAD 252 +GY ++ D H + +WD T H + +F+G V+D++W + + +V + Sbjct: 70 SGYYCASGDVHGNVRIWD--TTQTTHILKTTIPVFSGP---VKDISWDSESKRI-AAVGE 123 Query: 253 DQK----LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 308 ++ + ++DT +N + + +N + F P F + +GS D TVA+++ Sbjct: 124 GRERFGHVFLFDTGTSNGN-----LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP 178 Query: 309 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW---DLSKIG--EEQSTEDA 363 K K +F H + V+++P + ++ AS+G D + ++ D +K G E+ S ++ Sbjct: 179 PFKFK-STFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV 236 Query: 364 EDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMA 409 H+ + +W+P+ I S S D +++W +A Sbjct: 237 ------------AHSGSVFGLTWSPDGTK-IASASADKTIKIWNVA 269 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 37/141 (26%), Positives = 67/141 (47%), Gaps = 13/141 (9%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 L G + + + P+ ++S SDD+T+ ++ E K+ F HT V Sbjct: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF-------EGPPFKFKSTFGEHTKFVHS 195 Query: 237 VAWHLLHESLFGSVADDQKLMIWD----TRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI 292 V ++ SLF S D +++++ T+ S AH+ V L+++P I Sbjct: 196 VRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKI 254 Query: 293 LATGSADKTVALWDLRNLKLK 313 A+ SADKT+ +W++ LK++ Sbjct: 255 -ASASADKTIKIWNVATLKVE 274 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 33/110 (30%), Positives = 55/110 (50%), Gaps = 15/110 (13%) Query: 250 VADDQ--KLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL 307 VA DQ K++ + NN +++ HTA+V C+S++P LATGS D +V +W++ Sbjct: 507 VATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVWNM 565 Query: 308 RN------LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 + H+ S + V W NET + S+G D + W++ Sbjct: 566 NKPSDHPIIIKGAHAMSS----VNSVIW--LNETTIVSAGQDSNIKFWNV 609 Score = 29.6 bits (65), Expect = 3.0, Method: Compositional matrix adjust. Identities = 31/128 (24%), Positives = 56/128 (43%), Gaps = 14/128 (10%) Query: 281 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 340 +C++ + +F+ A G D V ++ L + H EI V +S +N L ++ Sbjct: 452 SCVALSNDKQFV-AVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFS-NNGAFLVAT 509 Query: 341 GTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSED 400 R++ + ++ E T F HTAK++ SW+P+ + + S D Sbjct: 510 DQSRKVIPYSVANNFELAHTN-------SWTF----HTAKVACVSWSPDNVR-LATGSLD 557 Query: 401 NIMQVWQM 408 N + VW M Sbjct: 558 NSVIVWNM 565 >5Z56-q nrPDB Length = 504 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 51/178 (28%), Positives = 79/178 (44%), Gaps = 24/178 (13%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 +R H+ GLS + YLLS+SDD DI +V D + + A Sbjct: 302 VRAHESAVTGLSLHAT-GDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP 360 Query: 237 VAWHLLHESLFGSVADDQKLMIWDT--RNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILA 294 +FG+ D ++ IWD R N + P H+ + ++F+ + + LA Sbjct: 361 DGL------IFGTGTMDSQIKIWDLKERTNVANFP-----GHSGPITSIAFSE-NGYYLA 408 Query: 295 TGSADKTVALWDLRNLK----LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHV 348 T + D +V LWDLR LK L+L + K IF + T LA GTD ++++ Sbjct: 409 TAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFD-----QSGTYLALGGTDVQIYI 461 >4LG8-A nrPDB Length = 354 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 51/178 (28%), Positives = 79/178 (44%), Gaps = 24/178 (13%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 +R H+ GLS + YLLS+SDD DI +V D + + A Sbjct: 152 VRAHESAVTGLSLHAT-GDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP 210 Query: 237 VAWHLLHESLFGSVADDQKLMIWDT--RNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILA 294 +FG+ D ++ IWD R N + P H+ + ++F+ + + LA Sbjct: 211 DGL------IFGTGTMDSQIKIWDLKERTNVANFP-----GHSGPITSIAFSE-NGYYLA 258 Query: 295 TGSADKTVALWDLRNLK----LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHV 348 T + D +V LWDLR LK L+L + K IF + T LA GTD ++++ Sbjct: 259 TAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFD-----QSGTYLALGGTDVQIYI 311 >3JRP-A nrPDB Length = 379 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 69/270 (25%), Positives = 107/270 (39%), Gaps = 55/270 (20%) Query: 177 LRGHQKEGYGLSW-NPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVE 235 L GH+ + + W +P L S S D + +W +E+ + H+A V Sbjct: 51 LTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIW-----KEENGRWSQIAVHAVHSASVN 105 Query: 236 DVAWHLLHE--SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS---- 289 V W HE L + D K+ + + + N T+ P +DAH VN S+ P + Sbjct: 106 SVQW-APHEYGPLLLVASSDGKVSVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEED 163 Query: 290 ----------EFILATGSADKTVALW----DLRNLKLKLHSFESHKDEIFQVQWSPHN-- 333 +F+ TG AD V +W D + L+ + E H D + V WSP Sbjct: 164 GEHNGTKESRKFV--TGGADNLVKIWKYNSDAQTYVLE-STLEGHSDWVRDVAWSPTVLL 220 Query: 334 ETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW- 392 + LAS DR +W T+D E GP + + K D W + W Sbjct: 221 RSYLASVSQDRTCIIW----------TQDNEQGPWKKTLL---KEEKFPDVLWRAS--WS 265 Query: 393 ----IICSVSEDNIMQVWQMAENVYNDEEP 418 ++ DN + +W+ EN+ EP Sbjct: 266 LSGNVLALSGGDNKVTLWK--ENLEGKWEP 293 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 34/123 (27%), Positives = 61/123 (49%), Gaps = 17/123 (13%) Query: 293 LATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWS-PHNETILASSGTDRRLHVWD 350 LAT S+DKT+ ++++ KL + H+ +++V W+ P TILAS D ++ +W Sbjct: 26 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 85 Query: 351 LSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNE--PWIICSVSEDNIMQVWQM 408 E+G + +H H+A ++ W P+E P ++ + S D + V + Sbjct: 86 ------------EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA-SSDGKVSVVEF 132 Query: 409 AEN 411 EN Sbjct: 133 KEN 135 >4BZK-B nrPDB Length = 297 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 69/270 (25%), Positives = 107/270 (39%), Gaps = 55/270 (20%) Query: 177 LRGHQKEGYGLSW-NPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVE 235 L GH+ + + W +P L S S D + +W +E+ + H+A V Sbjct: 49 LTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK-----EENGRWSQIAVHAVHSASVN 103 Query: 236 DVAWHLLHE--SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS---- 289 V W HE L + D K+ + + + N T+ P +DAH VN S+ P + Sbjct: 104 SVQW-APHEYGPLLLVASSDGKVSVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEED 161 Query: 290 ----------EFILATGSADKTVALW----DLRNLKLKLHSFESHKDEIFQVQWSPHN-- 333 +F+ TG AD V +W D + L+ + E H D + V WSP Sbjct: 162 GEHNGTKESRKFV--TGGADNLVKIWKYNSDAQTYVLE-STLEGHSDWVRDVAWSPTVLL 218 Query: 334 ETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW- 392 + LAS DR +W T+D E GP + + K D W + W Sbjct: 219 RSYLASVSQDRTCIIW----------TQDNEQGPWKKTLL---KEEKFPDVLWRAS--WS 263 Query: 393 ----IICSVSEDNIMQVWQMAENVYNDEEP 418 ++ DN + +W+ EN+ EP Sbjct: 264 LSGNVLALSGGDNKVTLWK--ENLEGKWEP 291 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 34/123 (27%), Positives = 60/123 (48%), Gaps = 17/123 (13%) Query: 293 LATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWS-PHNETILASSGTDRRLHVWD 350 LAT S+DKT+ ++++ KL + H+ +++V W+ P TILAS D ++ +W Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 351 LSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNE--PWIICSVSEDNIMQVWQM 408 E+G + +H H+A ++ W P+E P ++ S D + V + Sbjct: 84 ------------EENGRWSQIAVHAVHSASVNSVQWAPHEYGP-LLLVASSDGKVSVVEF 130 Query: 409 AEN 411 EN Sbjct: 131 KEN 133 >3JRO-A nrPDB Length = 753 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 87/214 (40%), Gaps = 43/214 (20%) Query: 177 LRGHQKEGYGLSW-NPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVE 235 L GH+ + + W +P L S S D + +W +E+ + H+A V Sbjct: 49 LTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIW-----KEENGRWSQIAVHAVHSASVN 103 Query: 236 DVAWHLLHES--LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS---- 289 V W HE L + D K+ + + + N T+ P +DAH VN S+ P + Sbjct: 104 SVQWAP-HEYGPLLLVASSDGKVSVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEED 161 Query: 290 ----------EFILATGSADKTVALW----DLRNLKLKLHSFESHKDEIFQVQWSPHN-- 333 +F+ TG AD V +W D + L+ + E H D + V WSP Sbjct: 162 GEHNGTKESRKFV--TGGADNLVKIWKYNSDAQTYVLE-STLEGHSDWVRDVAWSPTVLL 218 Query: 334 ETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGP 367 + LAS DR +W T+D E GP Sbjct: 219 RSYLASVSQDRTCIIW----------TQDNEQGP 242 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 34/123 (27%), Positives = 61/123 (49%), Gaps = 17/123 (13%) Query: 293 LATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWS-PHNETILASSGTDRRLHVWD 350 LAT S+DKT+ ++++ KL + H+ +++V W+ P TILAS D ++ +W Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 351 LSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNE--PWIICSVSEDNIMQVWQM 408 E+G + +H H+A ++ W P+E P ++ + S D + V + Sbjct: 84 ------------EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA-SSDGKVSVVEF 130 Query: 409 AEN 411 EN Sbjct: 131 KEN 133 >4BH6-A nrPDB Length = 308 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 28/83 (33%), Positives = 50/83 (60%), Gaps = 4/83 (4%) Query: 272 TVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP 331 T+++HT EV L +N ++ LA+G D V +++ + K + +F+ HK + + WSP Sbjct: 140 TIESHTQEVCGLKWN-VADNKLASGGNDNVVHVYEGTS-KSPILTFDEHKAAVKAMAWSP 197 Query: 332 HNETILASSG--TDRRLHVWDLS 352 H +LA+ G DRRL +W+++ Sbjct: 198 HKRGVLATGGGTADRRLKIWNVN 220 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 55/230 (23%), Positives = 94/230 (40%), Gaps = 32/230 (13%) Query: 128 EGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGL 187 G ++R + N V+ + + +L D P+P E + H +E GL Sbjct: 101 SGHIDRVACLSWNNHVLTSGSRDHRILHRDV----RMPDPFFET-----IESHTQEVCGL 151 Query: 188 SWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLF 247 WN N L S +D+ + +++ T K + F H A V+ +AW + Sbjct: 152 KWNVADNK-LASGGNDNVVHVYE--GTSKSPILT-----FDEHKAAVKAMAWSPHKRGVL 203 Query: 248 --GSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 305 G D++L IW N NTS +D+ + N + +E + + G + + LW Sbjct: 204 ATGGGTADRRLKIW---NVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLW 260 Query: 306 DLRNLK----LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 D ++ LK HSF + + S T+++ +G D L W L Sbjct: 261 DCNSMDPIAILKGHSF-----RVLHLTLSNDGTTVVSGAG-DETLRYWKL 304 >5A31-R nrPDB Length = 386 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 37/128 (28%), Positives = 67/128 (52%), Gaps = 11/128 (8%) Query: 227 FTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSH-TVDAHTAEVNCLSF 285 +GH V ++W+ + S + D +++ D R P T+++HT EV L + Sbjct: 169 LSGHIDRVACLSWN---NHVLTSGSRDHRILHRDVR---MPDPFFETIESHTQEVCGLKW 222 Query: 286 NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG--TD 343 N ++ LA+G D V +++ + K + +F+ HK + + WSPH +LA+ G D Sbjct: 223 N-VADNKLASGGNDNVVHVYEGTS-KSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTAD 280 Query: 344 RRLHVWDL 351 RRL +W++ Sbjct: 281 RRLKIWNV 288 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 55/230 (23%), Positives = 94/230 (40%), Gaps = 32/230 (13%) Query: 128 EGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGL 187 G ++R + N V+ + + +L D P+P E + H +E GL Sbjct: 170 SGHIDRVACLSWNNHVLTSGSRDHRILHRDV----RMPDPFFET-----IESHTQEVCGL 220 Query: 188 SWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLF 247 WN N L S +D+ + +++ T K + F H A V+ +AW + Sbjct: 221 KWNVADNK-LASGGNDNVVHVYE--GTSKSPILT-----FDEHKAAVKAMAWSPHKRGVL 272 Query: 248 --GSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 305 G D++L IW N NTS +D+ + N + +E + + G + + LW Sbjct: 273 ATGGGTADRRLKIW---NVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLW 329 Query: 306 DLRNLK----LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 D ++ LK HSF + + S T+++ +G D L W L Sbjct: 330 DCNSMDPIAILKGHSF-----RVLHLTLSNDGTTVVSGAG-DETLRYWKL 373 >6ELZ-p nrPDB Length = 460 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 47/165 (28%), Positives = 75/165 (45%), Gaps = 21/165 (12%) Query: 192 NLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVA 251 N GY S S DHTI WD+ R ID + ++ + +LL GS A Sbjct: 300 NTVGY--SVSQDHTIKTWDLVTA----RCIDTRTTSYSLLSIAQLSTLNLLA---CGSSA 350 Query: 252 DDQKLMIWDTRNNNTSKPSHT-VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 310 + + + D R +SK + + H V+ L P +E+IL +GS D TV +WD+R+ Sbjct: 351 --RHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRST 408 Query: 311 KLKLHSFESHK-------DEIFQVQWSPHNETILASSGTDRRLHV 348 K D++F V+W+ I S+G D+++ + Sbjct: 409 SPMYTITREDKSVQKGVNDKVFAVKWAEKVGII--SAGQDKKIQI 451 Score = 37.0 bits (84), Expect = 0.016, Method: Compositional matrix adjust. Identities = 51/218 (23%), Positives = 87/218 (39%), Gaps = 34/218 (15%) Query: 194 NGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADD 253 N +LSAS D++I W + KE V+D +ED+ + + + + Sbjct: 219 NSRILSASYDNSIGFW--STIYKEMTVVDP----------LEDI--NNPNNKISTAARKR 264 Query: 254 QKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK 313 +KL + D + P +++HTA V + F+ + + S D T+ WDL + Sbjct: 265 RKLTMKDGTIRRRA-PLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARC- 322 Query: 314 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLH---VWDLSKIGEEQSTEDAEDGPPEL 370 + + + + Q S N SS LH V SK+ ++Q Sbjct: 323 IDTRTTSYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLI---------- 372 Query: 371 LFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 GH +S P +I+CS S D ++VW + Sbjct: 373 -----GHKNFVSSLDTCPENEYILCSGSHDGTVKVWDV 405 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 39/125 (31%), Positives = 55/125 (44%), Gaps = 19/125 (15%) Query: 293 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW--- 349 + +GS D V WDL K +S H I V++ + T L S+G DR L +W Sbjct: 118 IISGSYDGIVRTWDLSGNVQKQYS--GHSGPIRAVKYISN--TRLVSAGNDRTLRLWKTK 173 Query: 350 --DLSKIGEEQSTE------DAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDN 401 DL ++Q+ E + EDG + L I GH A + + N I S S DN Sbjct: 174 NDDLKLTSQQQAQEDDDDEVNIEDG--KTLAILEGHKAPVVSIDVSDNSR--ILSASYDN 229 Query: 402 IMQVW 406 + W Sbjct: 230 SIGFW 234 >3JB9-g nrPDB Length = 558 Score = 48.1 bits (113), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 22/76 (28%), Positives = 42/76 (55%), Gaps = 1/76 (1%) Query: 275 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE 334 HT ++CL F P S +L +GS D + +W++ + + L +F+ H I + +S Sbjct: 264 GHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDGR 323 Query: 335 TILASSGTDRRLHVWD 350 + L++S D+ + +WD Sbjct: 324 SFLSTS-FDKTIKLWD 338 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 51/235 (21%), Positives = 94/235 (40%), Gaps = 29/235 (12%) Query: 178 RGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDV 237 +GH K L + P LLS S D+ I +W++ R F GH + D+ Sbjct: 263 KGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRT------FQGHARPIRDL 316 Query: 238 AWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSF--NPYSEFILAT 295 ++ S F S + D+ + +WDT K + ++ NC+ F +P Sbjct: 317 SFSQDGRS-FLSTSFDKTIKLWDTE---LGKCLNCFNSDRL-TNCVKFQVDPDKPNEFLA 371 Query: 296 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIG 355 G+ADK + +D+R+ + + +++ H I + + + + + +S D + W+ Sbjct: 372 GTADKRILQFDIRSPDI-VQAYDHHLGGINSITFLENGKRFVTTS-DDSSMRFWEYGT-- 427 Query: 356 EEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 410 P + F+ + + PN I C S DN + V+ E Sbjct: 428 -----------PVPIKFVADIAMHSMPRVALRPNGKSIACQ-SLDNCIYVYSAYE 470 Score = 27.7 bits (60), Expect = 8.9, Method: Compositional matrix adjust. Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 4/50 (8%) Query: 367 PPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDE 416 P + +F GHT IS + P ++ S S DN +++W+ VY+D Sbjct: 255 PKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWE----VYHDR 300 >4G56-B nrPDB Length = 357 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 43/174 (24%), Positives = 74/174 (42%), Gaps = 22/174 (12%) Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 H E ++ P + LS +D I LWD PK ID F + V Sbjct: 179 AHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTR-KPKPATRID----FCASDTIPTSVT 233 Query: 239 WHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSA 298 WH + F + + + + +N ++++ S H+ + L+++ +S LA+ S Sbjct: 234 WHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAV---HSQNITGLAYSYHSSPFLASISE 290 Query: 299 DKTVALWD------LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 346 D TVA+ D R+L SH+D + V WSP + + + G D ++ Sbjct: 291 DCTVAVLDADFSEVFRDL--------SHRDFVTGVAWSPLDHSKFTTVGWDHKV 336 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 22/59 (37%), Positives = 31/59 (52%), Gaps = 1/59 (1%) Query: 295 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSK 353 +G D +V +WDL K L S+ +H E+ V P +TI S G D R+ +WD K Sbjct: 156 SGGKDFSVKVWDLSQ-KAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRK 213 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 39/153 (25%), Positives = 59/153 (38%), Gaps = 28/153 (18%) Query: 197 LLSASDDHTICLWDI--------NATPK-EHR-VIDAKNIFTGHTAVVEDVAWHLLHESL 246 +L ASD + LW+I N K EH ++ ++F+ T V Sbjct: 108 ILVASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGTQAV------------ 155 Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 S D + +WD K + +AH++EVNC++ P + I + D + LWD Sbjct: 156 --SGGKDFSVKVWDLSQKAVLK---SYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWD 210 Query: 307 LRNLKLKLHSFESHKDEI-FQVQWSPHNETILA 338 R K D I V W P + A Sbjct: 211 TRKPKPATRIDFCASDTIPTSVTWHPEKDDTFA 243 >3JAP-g nrPDB Length = 326 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 45/166 (27%), Positives = 73/166 (43%), Gaps = 23/166 (13%) Query: 196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 255 Y +SAS D T+ LW++ E R F GHT V VA + S S + D+ Sbjct: 80 YAVSASWDKTLRLWNLATGNSEAR-------FVGHTGDVLSVAID-ANSSKIISASRDKT 131 Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS---------EFILATGSADKTVALWD 306 + +W+T ++ + HT V + P + + DK V W Sbjct: 132 IRVWNT----VGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWS 187 Query: 307 LRNLKLKLHS-FESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 L ++ + F H + I VQ SP + ++ AS+G D +++VW+L Sbjct: 188 LNEDSYRIEADFIGHNNYINVVQPSP-DGSLAASAGKDGQIYVWNL 232 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 36/139 (25%), Positives = 61/139 (43%), Gaps = 20/139 (14%) Query: 272 TVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL----RNLKLKLHSFESHKDEIFQV 327 T++ H V LS + +L +GS DKT+ W L + + + S++ H + V Sbjct: 13 TLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDV 72 Query: 328 QWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWN 387 S +++S D+ L +W+L+ G E F+ GHT + + + Sbjct: 73 VVSADGNYAVSAS-WDKTLRLWNLAT------------GNSEARFV--GHTGDVLSVAID 117 Query: 388 PNEPWIICSVSEDNIMQVW 406 N II S S D ++VW Sbjct: 118 ANSSKII-SASRDKTIRVW 135 >5UZ7-B nrPDB Length = 351 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 50/215 (23%), Positives = 87/215 (40%), Gaps = 16/215 (7%) Query: 166 EPSGECQPDLR--LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRV-ID 222 +P G Q R LRGH + Y + W + + L+SAS D + +WD T K H + + Sbjct: 49 DPVGRIQMRTRRTLRGHLAKIYAMHWGTD-SRLLVSASQDGKLIIWDSYTTNKVHAIPLR 107 Query: 223 AKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNC 282 + + T A + G + + + TR N + S + HT ++C Sbjct: 108 SSWVMTCAYAPSGNYV-------ACGGLDNICSIYNLKTREGNV-RVSRELAGHTGYLSC 159 Query: 283 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGT 342 F ++ + T S D T ALWD+ + +F H ++ + +P + S Sbjct: 160 CRFLDDNQIV--TSSGDTTCALWDIET-GQQTTTFTGHTGDVMSLSLAPDTR-LFVSGAC 215 Query: 343 DRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGH 377 D +WD+ + Q+ E + F G+ Sbjct: 216 DASAKLWDVREGMCRQTFTGHESDINAICFFPNGN 250 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 47/158 (29%), Positives = 69/158 (43%), Gaps = 14/158 (8%) Query: 197 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 256 ++++S D T LWDI + TGHT V ++ LF S A D Sbjct: 168 IVTSSGDTTCALWDIETGQQTTTF-------TGHTGDVMSLSLAP-DTRLFVSGACDASA 219 Query: 257 MIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR-NLKLKLH 315 +WD R + T H +++N + F P ATGS D T L+DLR + +L + Sbjct: 220 KLWDVREGMCRQ---TFTGHESDINAICFFPNGN-AFATGSDDATCRLFDLRADQELMTY 275 Query: 316 SFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSK 353 S ++ I V +S +LA D +VWD K Sbjct: 276 SHDNIICGITSVSFSKSGRLLLAGY-DDFNCNVWDALK 312 >2HES-X nrPDB Length = 330 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 57/241 (23%), Positives = 105/241 (43%), Gaps = 28/241 (11%) Query: 194 NGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADD 253 G L + S D I L ++ + +ID + T H + VAW H SL + + D Sbjct: 24 QGILATGSTDRKIKL--VSVKYDDFTLIDVLD-ETAHKKAIRSVAWRP-HTSLLAAGSFD 79 Query: 254 QKLMIWDTRNNNTSKPSH----TVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 309 + IW + ++ H EV ++++ + LAT S DK+V +W+ Sbjct: 80 STVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSN-DGYYLATCSRDKSVWIWETDE 138 Query: 310 LKLK---LHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 366 + + + H ++ V W P +E +LASS D + +W +D +D Sbjct: 139 SGEEYECISVLQEHSQDVKHVIWHP-SEALLASSSYDDTVRIW-----------KDYDD- 185 Query: 367 PPELLFIHGGHTAKI--SDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASE 424 E + + GH + SDF + +CS S+D+ ++VW+ + +D++ + + Sbjct: 186 DWECVAVLNGHEGTVWSSDFD-KTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAI 244 Query: 425 L 425 L Sbjct: 245 L 245 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 36/131 (27%), Positives = 66/131 (50%), Gaps = 13/131 (9%) Query: 284 SFNPYSEFILATGSADKTVALWDLRNLKLKLHSF---ESHKDEIFQVQWSPHNETILASS 340 SF+ +S+ ILATGS D+ + L ++ L +HK I V W PH ++LA+ Sbjct: 19 SFD-FSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHT-SLLAAG 76 Query: 341 GTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSED 400 D + +W +E+S + + +LL I GH ++ +W+ N+ + + + S D Sbjct: 77 SFDSTVSIW-----AKEESADRTFE--MDLLAIIEGHENEVKGVAWS-NDGYYLATCSRD 128 Query: 401 NIMQVWQMAEN 411 + +W+ E+ Sbjct: 129 KSVWIWETDES 139 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 53/232 (22%), Positives = 104/232 (44%), Gaps = 13/232 (5%) Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 H+K ++W P+ L + S D T+ +W + +D I GH V+ VA Sbjct: 56 AHKKAIRSVAWRPH-TSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVA 114 Query: 239 WHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTV-DAHTAEVNCLSFNPYSEFILATGS 297 W L + + D+ + IW+T + +V H+ +V + ++P SE +LA+ S Sbjct: 115 WSNDGYYL-ATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHP-SEALLASSS 172 Query: 298 ADKTVALW-DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGT-DRRLHVWDLSKIG 355 D TV +W D + + H+ ++ + SG+ D + VW +G Sbjct: 173 YDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKY--MG 230 Query: 356 EEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 +++ +D ++ E + + H ++ + +W N +I SV D ++ V++ Sbjct: 231 DDE--DDQQEWVCEAI-LPDVHKRQVYNVAWGFNG--LIASVGADGVLAVYE 277 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 55/257 (21%), Positives = 98/257 (38%), Gaps = 65/257 (25%) Query: 156 FDYTKHPSKPEPSGECQPDLRL----RGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDI 211 FD T E S + ++ L GH+ E G++W+ N YL + S D ++ +W+ Sbjct: 78 FDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWS-NDGYYLATCSRDKSVWIWET 136 Query: 212 NATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSH 271 + + +E+ I ++ H+ V+ V WH E+L S + D + IW +++ + Sbjct: 137 DESGEEYECI---SVLQEHSQDVKHVIWHP-SEALLASSSYDDTVRIWKDYDDDWECVA- 191 Query: 272 TVDAHTAEVNCLSFNPY-SEFILATGSADKTVALW--------DLRNLKLKLHSFESHKD 322 ++ H V F+ F L +GS D TV +W D + + + HK Sbjct: 192 VLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKR 251 Query: 323 EIFQVQWS----------------------------------------------PHNETI 336 +++ V W + +TI Sbjct: 252 QVYNVAWGFNGLIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTI 311 Query: 337 LASSGTDRRLHVWDLSK 353 LA+ G D ++ W L K Sbjct: 312 LATGGDDGIVNFWSLEK 328 >6J6H-n nrPDB Length = 455 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 81/175 (46%), Gaps = 16/175 (9%) Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 GH + L + P +LS +DHTI +WD + + F GH ++ + Sbjct: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF------YHDYECLRDFQGHNKPIKALR 213 Query: 239 WHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSA 298 + +S F S + D+ + IWDT H +++ A+V NP+ EFI+ G + Sbjct: 214 FTEDCQS-FLSSSFDRSVKIWDTETGKVKTRLH-LNSTPADVESRPTNPH-EFIV--GLS 268 Query: 299 DKTVALWDLR---NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWD 350 + + +D R N L + +++ H I +++ P ++SS D+ + +W+ Sbjct: 269 NSKILHYDDRVSENQGL-VQTYDHHLSSILALKYFPDGSKFISSS-EDKTVRIWE 321 Score = 28.1 bits (61), Expect = 7.7, Method: Compositional matrix adjust. Identities = 20/76 (26%), Positives = 33/76 (43%), Gaps = 7/76 (9%) Query: 166 EPSGECQPDLRLRGHQKEGYGLSWNPNLNG-YLLSASDDHTICLWDINATPKEHRVIDAK 224 +P + P +GH GYG+S + +G Y+ S + WD N + R+++ Sbjct: 366 KPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTS----RLLN-- 419 Query: 225 NIFTGHTAVVEDVAWH 240 NI + V WH Sbjct: 420 NIKIPGNKPITQVDWH 435 >5K1B-B nrPDB Length = 677 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 46/199 (23%), Positives = 80/199 (40%), Gaps = 19/199 (9%) Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 L +P LN L +A D I +W +N ++ + ++ HT V D+ ++ Sbjct: 35 ALQLDPALN-RLFTAGRDSIIRIWSVNQHKQDPYIASMEH----HTDWVNDIVLCCNGKT 89 Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 305 L S + D + +W N + T+ H V L++ E + + G D+ + LW Sbjct: 90 LI-SASSDTTVKVW---NAHKGFCMSTLRTHKDYVKALAYAKDKELVASAG-LDRQIFLW 144 Query: 306 DLRNLK--------LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEE 357 D+ L + S +KD I+ + + TI+ S T++ L VWD + Sbjct: 145 DVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLG-TIIVSGSTEKVLRVWDPRTCAKL 203 Query: 358 QSTEDAEDGPPELLFIHGG 376 + D LL G Sbjct: 204 MKLKGHTDNVKALLLNRDG 222 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 41/164 (25%), Positives = 74/164 (45%), Gaps = 19/164 (11%) Query: 197 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 256 L+SAS D T+ +W+ H+ + T H V+ +A+ E L S D+++ Sbjct: 90 LISASSDTTVKVWN------AHKGFCMSTLRT-HKDYVKALAYAKDKE-LVASAGLDRQI 141 Query: 257 MIWD-------TRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 309 +WD T +NNT S ++ + + L+ N I+ +GS +K + +WD R Sbjct: 142 FLWDVNTLTALTASNNTVTTS-SLSGNKDSIYSLAMNQLGT-IIVSGSTEKVLRVWDPRT 199 Query: 310 LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSK 353 KL + H D + + + L+ S +D + +W L + Sbjct: 200 CA-KLMKLKGHTDNVKALLLNRDGTQCLSGS-SDGTIRLWSLGQ 241 >6F1U-h nrPDB Length = 612 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 1/89 (1%) Query: 292 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 + T S D TV LW +N K L+SFE + ++ V WSP + + A RL +W+L Sbjct: 470 LFVTSSFDWTVKLWSTKNNK-PLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNL 528 Query: 352 SKIGEEQSTEDAEDGPPELLFIHGGHTAK 380 + E + + +G P L + H+ + Sbjct: 529 NNDTEVPTASISVEGNPALNRVRWTHSGR 557 >3EI3-B nrPDB Length = 383 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 26/77 (33%), Positives = 44/77 (57%), Gaps = 4/77 (5%) Query: 276 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES---HKDEIFQVQWSPH 332 H A+V FNP ++++AT S D TV LWDLRN+K K +S+ + H+ + ++P Sbjct: 203 HKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDK-NSYIAEMPHEKPVNAAYFNPT 261 Query: 333 NETILASSGTDRRLHVW 349 + T L ++ + V+ Sbjct: 262 DSTKLLTTDQRNEIRVY 278 Score = 28.5 bits (62), Expect = 5.7, Method: Compositional matrix adjust. Identities = 11/40 (27%), Positives = 24/40 (60%) Query: 320 HKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQS 359 HK ++ +++P + ++A+S D + +WDL I ++ S Sbjct: 203 HKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNS 242 >5XYI-g nrPDB Length = 335 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 52/225 (23%), Positives = 94/225 (41%), Gaps = 43/225 (19%) Query: 192 NLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDV-----AWHLLHESL 246 N + YL+SAS D + +W +N T ++ + I GH V DV A HLL S Sbjct: 43 NEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLI--GHNHFVSDVSLSRDASHLLTSSW 100 Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 D L +WD T K H +V ++F+P + I++ G D V +W+ Sbjct: 101 ------DSTLRLWDLSTRTTKK---LFLGHKKDVLGVTFSPCNRRIISVGR-DNQVKIWN 150 Query: 307 L---RNLKLKLHSFESHKDEIFQVQWSPH-NET---ILASSGTDRRLHVWDLSKIGEEQS 359 + +L+ S+ + V +P +ET ++A D ++++W + K Sbjct: 151 ILGENKAELQCSSW------VTSVACAPMADETSPLVIAVGCWDGKVYIWSIEK------ 198 Query: 360 TEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQ 404 +L+ H + + + P+ W+I S+ ++ Sbjct: 199 -------EAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVM 236 >6BX3-B nrPDB Length = 412 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 27/89 (30%), Positives = 47/89 (52%), Gaps = 6/89 (6%) Query: 268 KPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL---RNLKLKLHSFESHKDEI 324 K +HT++ + CL F+P ++ LA G A+ + ++D+ R + + + +H I Sbjct: 17 KLTHTIE-NPLRTECLQFSPCGDY-LALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI 74 Query: 325 FQVQWSPHNETILASSGTDRRLHVWDLSK 353 + WSP +L SS D + +WDLSK Sbjct: 75 TSIAWSPDGRLLLTSS-RDWSIKLWDLSK 102 >4L9O-A nrPDB Length = 349 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 32/117 (27%), Positives = 57/117 (48%), Gaps = 16/117 (13%) Query: 293 LATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWS-PHNETILASSGTDRRLHVWD 350 LAT S+DKT+ ++++ +L + H+ ++QV W+ P ILAS D ++ +W Sbjct: 84 LATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWK 143 Query: 351 LSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNE--PWIICSVSEDNIMQV 405 ++G + H H A ++ SW P+E P ++C+ S+ I V Sbjct: 144 ------------EDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIV 188 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 60/259 (23%), Positives = 107/259 (41%), Gaps = 31/259 (11%) Query: 121 IEIKINHEGEVNRARYM-PQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRG 179 +E I HEG V + + P+ ++A+ + VL++ E +G Sbjct: 106 VETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWK--------EDNGVWNKVAEHSV 157 Query: 180 HQKEGYGLSWNPNLNG-YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 HQ +SW P+ G LL AS D I + + ++ GH V + Sbjct: 158 HQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPIV-----IQGHAIGVNAAS 212 Query: 239 WHLL----HESLFGSVADDQKLMIWDTRNNNTSKP---SHTVDAHTAEVNCLSFNP--YS 289 W + + F S D + IW R ++ +K H+ V ++++P S Sbjct: 213 WAPISLPDNTRRFVSGGCDNLVKIW--RYDDAAKTFIEEEAFQGHSDWVRDVAWSPSRLS 270 Query: 290 EFILATGSADKTVALW--DLRNLKLKLHSFESHK--DEIFQVQWSPHNETILASSGTDRR 345 + +AT S D+TV +W D ++ K + K D ++ WS +LA SG D + Sbjct: 271 KSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSG-NVLAISGGDNK 329 Query: 346 LHVWDLSKIGEEQSTEDAE 364 + +W + G+ +S + + Sbjct: 330 VTLWKENIQGKWESAGEVD 348 >4YCZ-A nrPDB Length = 876 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 49/211 (23%), Positives = 80/211 (37%), Gaps = 36/211 (17%) Query: 228 TGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSF-N 286 +GH ++ D L + + D+ + I++ T + + T+ H V C+S+ + Sbjct: 15 SGHDDMIHDAVLDYYGRRL-ATCSSDRTIKIFEI-EGETQRLTETLKGHDGAVWCVSWAH 72 Query: 287 PYSEFILATGSADKTVALW-DLRNLKLKLHSFESHKDEIFQVQWSPHNE-TILASSGTDR 344 P ILA+ D V +W +L ++ F HK + V WSPH +LA + +D Sbjct: 73 PKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDG 132 Query: 345 RLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNP-NEPWIICSV------ 397 + V + E S I H ++ SW P P I S Sbjct: 133 NVSVLEFRDNSWEHS-------------IFHAHGLGVNSVSWAPATSPGSIVSSKPGPKS 179 Query: 398 ---------SEDNIMQVWQM--AENVYNDEE 417 DN +++W A N Y E Sbjct: 180 TGNRRFVTGGSDNALKIWAYDPATNTYKLER 210 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 48/205 (23%), Positives = 86/205 (41%), Gaps = 36/205 (17%) Query: 187 LSWNPNLNGYLLS-ASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW------ 239 +SW+P+ G LL+ AS D + + + EH +IF H V V+W Sbjct: 114 VSWSPHEAGCLLACASSDGNVSVLEFRDNSWEH------SIFHAHGLGVNSVSWAPATSP 167 Query: 240 ----------HLLHESLFGSVADDQKLMIW--DTRNNNTSKPSHTVDAHTAEVNCLSFNP 287 F + D L IW D N + HT V ++++P Sbjct: 168 GSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSP 227 Query: 288 --YSEFILATGSADKTVALW-----DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 340 + +A+ S D+TV +W + K+ +F++ +++V WS + +LA+S Sbjct: 228 TVLQKSYIASASEDRTVRIWTSDPANPLQWNCKVLNFDA---AVWRVSWS-LSGNVLAAS 283 Query: 341 GTDRRLHVWDLSKIGEEQSTEDAED 365 G D ++ +W + GE + + E+ Sbjct: 284 GGDNKVTLWKENLKGEWECVKTIEE 308 >4E5Z-B nrPDB Length = 436 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 21/66 (31%), Positives = 35/66 (53%), Gaps = 2/66 (3%) Query: 276 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES--HKDEIFQVQWSPHN 333 H +V ++ NP ++ LAT S D+TV +WDLR ++ K S H+ + +SP Sbjct: 249 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 308 Query: 334 ETILAS 339 +L + Sbjct: 309 ARLLTT 314 Score = 30.0 bits (66), Expect = 2.0, Method: Compositional matrix adjust. Identities = 13/36 (36%), Positives = 23/36 (63%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDIN 212 LR H+K+ ++ NP + +L +AS D T+ +WD+ Sbjct: 246 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR 281 Score = 28.9 bits (63), Expect = 4.7, Method: Compositional matrix adjust. Identities = 15/56 (26%), Positives = 28/56 (50%), Gaps = 10/56 (17%) Query: 304 LWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQS 359 LW+LR HK ++ V +P + LA++ D+ + +WDL ++ + S Sbjct: 243 LWNLR----------MHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKAS 288 >5WLC-LS nrPDB Length = 594 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 33/104 (31%), Positives = 52/104 (50%), Gaps = 12/104 (11%) Query: 254 QKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL----RN 309 +KL I ++ N S PSH+ + LSF+P S+ +L TG DKT+ ++ + + Sbjct: 231 KKLDIVRLKDANASHPSHSA------IQSLSFHP-SKPLLLTGGYDKTLRIYHIDGKTNH 283 Query: 310 LKLKLHSFESH-KDEIFQVQWSPHNETILASSGTDRRLHVWDLS 352 L LH S + F S N+ + ++G R +H WDLS Sbjct: 284 LVTSLHLVGSPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLS 327 >6EMK-B nrPDB Length = 303 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/164 (26%), Positives = 71/164 (43%), Gaps = 17/164 (10%) Query: 197 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 256 L+SA DHTI W+ T R I + + D + L + A Q + Sbjct: 5 LVSAGYDHTIRFWEA-LTGVCSRTIQHSDSQVNRLEITND-------KKLLAT-AGHQNV 55 Query: 257 MIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 316 ++D R N P + + H V +SF + +++ T S D T+ +WD+R+ + + Sbjct: 56 RLYDIRTTN-PNPVASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVRSPSIPRN- 112 Query: 317 FESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 360 H + +V P N+ L S D + +WDL GE Q T Sbjct: 113 -YKHNAPVNEVVIHP-NQGELISCDRDGNIRIWDL---GENQCT 151 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 50/230 (21%), Positives = 89/230 (38%), Gaps = 66/230 (28%) Query: 173 PDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDIN--ATPKEHRVIDAKNIFTGH 230 P GH+ +S+ + N +++++S+D TI +WD+ + P+ ++ H Sbjct: 67 PVASFEGHRGNVTSVSFQQD-NRWMVTSSEDGTIKVWDVRSPSIPRNYK----------H 115 Query: 231 TAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTS----------------------- 267 A V +V H L S D + IWD N + Sbjct: 116 NAPVNEVVIHPNQGELI-SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 Query: 268 -------------KPSHTVDAHTAEVNCLSFNPYSEFI-----------LATGSADKTVA 303 P+HT +H V F +S +I LAT SAD T Sbjct: 175 AAANTKGNCYVWEMPNHTDASHLKPVT--KFRAHSTYITRILLSSDVKHLATCSADHTAR 232 Query: 304 LWDL-RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLS 352 +W + + KL+ + + H+ ++ +S + L ++ +D + +WDLS Sbjct: 233 VWSIDDDFKLET-TLDGHQRWVWDCAFSA-DSAYLVTASSDHYVRLWDLS 280 >5WLC-LJ nrPDB Length = 513 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 47/189 (24%), Positives = 74/189 (39%), Gaps = 41/189 (21%) Query: 239 WHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSA 298 +H + + +DD+ +WD +N +P + T V LSF P + ++ATGS Sbjct: 132 FHTQDNKILATASDDRVTRLWDI--SNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSY 189 Query: 299 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTD------RRLHVWDLS 352 D + L+D R+ S I+ + E ++A S T VWDL+ Sbjct: 190 DGLIRLYDTRS---------SGSTPIYSLNHDQPVENVIAVSPTQIVSCGGNNFKVWDLT 240 Query: 353 ---KIGEEQSTEDAE---------DGPPELLFIHG---GHTAKISD--------FSWNPN 389 K+ E + A D P + I GH K+ D F W + Sbjct: 241 SNKKLYERGNFNKAVTCLDYVENFDSPMQSALIASSLDGH-VKVFDPLDNFQVKFGWKFS 299 Query: 390 EPWIICSVS 398 P + C+VS Sbjct: 300 GPVLSCAVS 308 Score = 35.4 bits (80), Expect = 0.051, Method: Compositional matrix adjust. Identities = 26/115 (22%), Positives = 50/115 (43%), Gaps = 13/115 (11%) Query: 292 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 +L G A V+++D N + L S + ++ + ILA++ DR +WD+ Sbjct: 95 LLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKILATASDDRVTRLWDI 154 Query: 352 SKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 S E P+L G T + S+ P P ++ + S D +++++ Sbjct: 155 SNAYE-----------PQLELT--GATDYVRTLSFIPAAPHLVATGSYDGLIRLY 196 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 31/138 (22%), Positives = 55/138 (39%), Gaps = 10/138 (7%) Query: 258 IWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF 317 ++D+ N T S ++A T + F+ ILAT S D+ LWD+ N Sbjct: 107 VYDSYNPRTILLS--INASTHPTHVTKFHTQDNKILATASDDRVTRLWDISNAYEPQLEL 164 Query: 318 ESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGE--------EQSTEDAEDGPPE 369 D + + + P ++A+ D + ++D G +Q E+ P Sbjct: 165 TGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVENVIAVSPT 224 Query: 370 LLFIHGGHTAKISDFSWN 387 + GG+ K+ D + N Sbjct: 225 QIVSCGGNNFKVWDLTSN 242 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 40/162 (24%), Positives = 74/162 (45%), Gaps = 18/162 (11%) Query: 194 NGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADD 253 N L +ASDD LWDI+ + + TG T V +++ L + + D Sbjct: 137 NKILATASDDRVTRLWDIS------NAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYD 190 Query: 254 QKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK 313 + ++DTR++ S P ++++ N ++ +P I++ G + V WDL + K K Sbjct: 191 GLIRLYDTRSSG-STPIYSLNHDQPVENVIAVSPTQ--IVSCGGNNFKV--WDLTSNK-K 244 Query: 314 LHSFESHKDEIFQVQW-----SPHNETILASSGTDRRLHVWD 350 L+ + + + + SP ++ASS D + V+D Sbjct: 245 LYERGNFNKAVTCLDYVENFDSPMQSALIASS-LDGHVKVFD 285 >6BX3-A nrPDB Length = 314 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 47/179 (26%), Positives = 77/179 (43%), Gaps = 23/179 (12%) Query: 180 HQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW 239 H + L W+P+ + +ASDD ++ H + F GHTA V + + Sbjct: 53 HARPFSELCWSPD-GQCIATASDDFSV--------EIIHLSYGLLHTFIGHTAPVISLTF 103 Query: 240 HLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSAD 299 + LF S + D+ + IWDT N + K T+ AH+ V + IL++GS D Sbjct: 104 NRKGNLLFTS-SMDESIKIWDTLNGSLMK---TISAHSEAVVSVDVPMNDSSILSSGSYD 159 Query: 300 KTVALWDLRNLKLKLHSFESHKD--------EIFQVQWSPHNETILASSGTDRRLHVWD 350 + ++D L + KD I QV++S + +L S D + +WD Sbjct: 160 GLIRIFDAETGHC-LKTLTYDKDWKRENGVVPISQVKFSENARYLLVKS-LDGVVKIWD 216 >5LTD-A nrPDB Length = 525 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 26/106 (24%), Positives = 58/106 (54%), Gaps = 10/106 (9%) Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 315 ++I+D + T +P+ ++AH + ++ + +LAT S T+ +KL+ Sbjct: 204 VIIFDAK---TLQPTSVIEAHRTSLAAIALSK-DGLLLATASDKGTIIRVFSVATGIKLY 259 Query: 316 SFE--SHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQS 359 F ++ +I+ + +SP N ++ASS T+ +H++ ++GEE++ Sbjct: 260 QFRRGTYPTKIYSLAFSPDNRFVIASSATE-TVHIF---RLGEEEA 301 >6EOJ-D nrPDB Length = 470 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 41/166 (24%), Positives = 64/166 (38%), Gaps = 40/166 (24%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDIN------------------------ 212 L GH + W+P + G + SAS D+ + LWD Sbjct: 215 LSGHHWDVKSCDWHPEM-GLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTK 273 Query: 213 -------ATPKEHRVIDAKNIFTGHTAVVED-----VAWHLLHESLFGSVADDQKLMIWD 260 + K RV D + V ++ + WH ++ES+F D L +D Sbjct: 274 GNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFD 333 Query: 261 TRNNNTSKPSHTVD-AHTAEVNCLSFNPYSEFILATGSADKTVALW 305 N ++P T+ AH + LS+NP I AT + D+T+ W Sbjct: 334 LL-QNLNEPILTIPYAHDKCITSLSYNPVGH-IFATAAKDRTIRFW 377 Score = 36.2 bits (82), Expect = 0.032, Method: Compositional matrix adjust. Identities = 29/134 (21%), Positives = 62/134 (46%), Gaps = 18/134 (13%) Query: 273 VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPH 332 + AH + V + ++ S++++ +G AD + +W N + +H + I + +S Sbjct: 131 MQAHDSAVTTMKYSHDSDWMI-SGDADGMIKIWQ-PNFSMVKEIDAAHTESIRDMAFS-S 187 Query: 333 NETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 392 N++ + D L +W+ S +E+ + GH + W+P E Sbjct: 188 NDSKFVTCSDDNILKIWNFSNGKQER--------------VLSGHHWDVKSCDWHP-EMG 232 Query: 393 IICSVSEDNIMQVW 406 +I S S+DN++++W Sbjct: 233 LIASASKDNLVKLW 246 >6E29-D nrPDB Length = 345 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 28/102 (27%), Positives = 45/102 (44%), Gaps = 11/102 (10%) Query: 250 VADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 309 ++DD L + NT + H+ C+ FN +F LA+G D TV +WDL Sbjct: 6 LSDDYLLQDYPENITNTIRSGHS--------TCVRFNRKGDF-LASGRVDGTVVIWDLET 56 Query: 310 LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 + + H I + WS +L S+ ++ +WDL Sbjct: 57 MGVA-RKLRGHSKNITSLSWSRCGRYLL-SACQGWKVILWDL 96 Score = 31.6 bits (70), Expect = 0.63, Method: Compositional matrix adjust. Identities = 16/37 (43%), Positives = 20/37 (54%), Gaps = 1/37 (2%) Query: 176 RLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDIN 212 +LRGH K LSW+ YLLSA + LWD+ Sbjct: 62 KLRGHSKNITSLSWS-RCGRYLLSACQGWKVILWDLQ 97 Score = 30.0 bits (66), Expect = 2.3, Method: Compositional matrix adjust. Identities = 15/72 (20%), Positives = 36/72 (50%), Gaps = 1/72 (1%) Query: 281 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 340 N ++F+ E++ A+ + + +W+ + L + E K+E ++W PH + A Sbjct: 275 NHVAFSATGEYVAASTYNNHELYIWERGHGSL-VRMLEGPKEEQGVIEWHPHRALLAACG 333 Query: 341 GTDRRLHVWDLS 352 R+++W ++ Sbjct: 334 LETGRINIWSVT 345 >3BG0-A nrPDB Length = 316 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 63/277 (22%), Positives = 102/277 (36%), Gaps = 43/277 (15%) Query: 117 GKIEIEIKINHEGEVNRARYM-PQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDL 175 G+I I HEG V + + P ++A+ + V+++ E +G + Sbjct: 46 GQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW--------REENGTWEKSH 97 Query: 176 RLRGHQKEGYGLSWNPNLNGYLLS-ASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVV 234 GH + W P+ G +L+ S D I L T + K I HT Sbjct: 98 EHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL----LTYTGEGQWEVKKINNAHTIGC 153 Query: 235 EDVAWH--LLHESL--------------FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTA 278 V+W ++ SL F S D + +W + K ++AH+ Sbjct: 154 NAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSD 213 Query: 279 EVNCLSFNPYSEF---ILATGSADKTVALWDLRNLKLK------LHSFESHKDEIFQVQW 329 V +++ P +A+ S D V +W + LH F D ++ V W Sbjct: 214 WVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKF---NDVVWHVSW 270 Query: 330 SPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 366 S ILA SG D ++ +W S G+ D G Sbjct: 271 SI-TANILAVSGGDNKVTLWKESVDGQWVCISDVNKG 306 Score = 37.4 bits (85), Expect = 0.012, Method: Compositional matrix adjust. Identities = 38/145 (26%), Positives = 62/145 (42%), Gaps = 15/145 (10%) Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSF-NPYSEFILATGSADKTVALW 305 + + D+ + I+D RN + + H V +++ +P ILA+ S D+ V +W Sbjct: 28 LATCSSDRSVKIFDVRNGGQILIA-DLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW 86 Query: 306 DLRNLKL-KLHSFESHKDEIFQVQWSPHN-ETILASSGTDRRLHVWDLSKIGEEQSTEDA 363 N K H H + V W+PH+ ILA +D + + L+ GE Sbjct: 87 REENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL--LTYTGE------- 137 Query: 364 EDGPPELLFIHGGHTAKISDFSWNP 388 G E+ I+ HT + SW P Sbjct: 138 --GQWEVKKINNAHTIGCNAVSWAP 160 >5CXC-A nrPDB Length = 510 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 19/66 (28%), Positives = 36/66 (54%) Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 305 L + + + + D R ++ + T+ H +V LS +P +E+ L +GS D T +W Sbjct: 372 LLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVW 431 Query: 306 DLRNLK 311 DLR+++ Sbjct: 432 DLRSVR 437 Score = 37.4 bits (85), Expect = 0.012, Method: Compositional matrix adjust. Identities = 56/278 (20%), Positives = 110/278 (39%), Gaps = 42/278 (15%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H + A+++ + +A+ V V+ YT+ +GE +P L L GH Sbjct: 190 GHTASIKAAKFLTSDR--LASAGMDRTVRVWKYTE---SDHFTGELKPTLELYGHTGS-- 242 Query: 186 GLSWNPNLNGY---LLSASDDHTICLW----------DINATPKEHRVIDAKNIFTGHTA 232 + W +++G+ +L+AS D I W D + P H K + TA Sbjct: 243 -VDWL-DVDGHSKHILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSVSTA 300 Query: 233 VVEDVA-WHLLHESLFGSVADDQ-KLMIWDTRNNNTSKPSHTVDAHTAEV---------- 280 + W + ++ D + + + + ++T + T+D T +V Sbjct: 301 QRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVR---TLDLTTGQVVSTLTLTHPL 357 Query: 281 ---NCLSFNPYSEFILATGSADKTVALWDLR--NLKLKLHSFESHKDEIFQVQWSPHNET 335 + L+ + +LA G++ + + + D R + + + H +++ + SP NE Sbjct: 358 LSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEY 417 Query: 336 ILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFI 373 L S D VWDL + E + G E +++ Sbjct: 418 SLVSGSHDGTCRVWDLRSVRPATKEEGSLGGVSEPVYV 455 >5BJS-A nrPDB Length = 605 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 33/144 (22%), Positives = 67/144 (46%), Gaps = 15/144 (10%) Query: 280 VNCLSFNPYS-EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 338 +C S +P + + +L + V ++++ KL + H I + SP N I+A Sbjct: 137 ASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKL-YRTLVGHGGGINDLATSPANPYIIA 195 Query: 339 SSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHG-GHTAKISDFSWNPNEPWIICSV 397 S+ D + +W L+ E+Q P + + G GH+ + +++ N +++ S Sbjct: 196 SASDDTTIRIWSLAPEHEKQ---------PCVCILGGEGHSYDLLSVAFHDNGRYVL-SA 245 Query: 398 SEDNIMQVWQMAENVYNDEEPEIP 421 D ++ +W + E + +E EIP Sbjct: 246 GHDQVINLWALPE--FPNEHMEIP 267 Score = 37.4 bits (85), Expect = 0.011, Method: Compositional matrix adjust. Identities = 53/246 (21%), Positives = 93/246 (37%), Gaps = 32/246 (13%) Query: 125 INHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEG 184 + H G +N P N +IA+ + + + ++ P E QP + + G + Sbjct: 175 VGHGGGINDLATSPANPYIIASASDDTTIRIWSLA-------PEHEKQPCVCILGGEGHS 227 Query: 185 YGL-SWNPNLNG-YLLSASDDHTICLWDINATPKEHRVIDAKNIFTG------HTAVVED 236 Y L S + NG Y+LSA D I LW + P EH I + H +V+ Sbjct: 228 YDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDC 287 Query: 237 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKP-SHTVDAHTAEVNCLSFNPYSEFILAT 295 VA++ + + + +++W ++ P +DA T Y Sbjct: 288 VAFY--GDLILSRACHEDTIVLWRIEGFSSDDPIPGPLDAPTPTDMTKQTRSYFT----- 340 Query: 296 GSADKTVALWDLRNLKLKLHSFESHKDEI-----FQVQWSPHNETILASSGTDRRLHVWD 350 TV+ + +L F + + F++ P ILA + + WD Sbjct: 341 ----PTVSPQSRPAMFTRLAQFHTPDCGVQFFMRFRMYHVPGKHPILAFANAKSKTFFWD 396 Query: 351 LSKIGE 356 L++ GE Sbjct: 397 LARFGE 402 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 29/137 (21%), Positives = 57/137 (41%), Gaps = 13/137 (9%) Query: 201 SDDHTICLWDINATPKEHRVIDAK--NIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMI 258 +D +C+ K + V + K GH + D+A + + S +DD + I Sbjct: 146 TDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRI 205 Query: 259 WDTRNNNTSKPSHTV---DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 315 W + +P + + H+ ++ ++F+ ++L+ G D+ + LW L Sbjct: 206 WSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGH-DQVINLW-------ALP 257 Query: 316 SFESHKDEIFQVQWSPH 332 F + EI V + PH Sbjct: 258 EFPNEHMEIPIVIYYPH 274 >6Q8F-A nrPDB Length = 514 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 37/159 (23%), Positives = 74/159 (46%), Gaps = 11/159 (6%) Query: 196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES---LFGSVAD 252 YL++ S D I +W+ T K + D K + +++D + + + A Sbjct: 229 YLVTGSVDGFIEVWNFT-TGKIRK--DLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQ 285 Query: 253 DQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL 312 D K+ +W ++ + AH+ V CLSF+ S IL + S D+T+ + L++ K Sbjct: 286 DGKIKVWKIQSGQCLRRFER--AHSKGVTCLSFSKDSSQIL-SASFDQTIRIHGLKSGK- 341 Query: 313 KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 L F H + + ++ I+++S +D + +W++ Sbjct: 342 TLKEFRGHSSFVNEATFTQDGHYIISAS-SDGTVKIWNM 379 Score = 33.1 bits (74), Expect = 0.23, Method: Compositional matrix adjust. Identities = 31/131 (23%), Positives = 63/131 (48%), Gaps = 21/131 (16%) Query: 280 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFE-SHKDEIFQVQWSPHNETILA 338 V C+ F+ +E +LATG+ D + +W +++ + L FE +H + + +S + IL+ Sbjct: 268 VLCMCFSRDTE-MLATGAQDGKIKVWKIQSGQC-LRRFERAHSKGVTCLSFSKDSSQILS 325 Query: 339 SSGTDR-RLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSV 397 +S R+H K +E GH++ +++ ++ + +II S Sbjct: 326 ASFDQTIRIHGLKSGKTLKE----------------FRGHSSFVNEATFTQDGHYII-SA 368 Query: 398 SEDNIMQVWQM 408 S D +++W M Sbjct: 369 SSDGTVKIWNM 379 >6GMH-W nrPDB Length = 305 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 47/183 (25%), Positives = 95/183 (51%), Gaps = 17/183 (9%) Query: 168 SGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIF 227 SG+ + L RG K ++++P+ YL S + D I ++DI AT K ++ Sbjct: 137 SGKKEYSLDTRG--KFILSIAYSPD-GKYLASGAIDGIINIFDI-ATGKLLHTLE----- 187 Query: 228 TGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP 287 GH + + + L + +DD + I+D ++ N + T+ H + V ++F P Sbjct: 188 -GHAMPIRSLTFSP-DSQLLVTASDDGYIKIYDVQHANLAG---TLSGHASWVLNVAFCP 242 Query: 288 YSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLH 347 + + S+DK+V +WD+ + +H+F H+D+++ V+++ + I+ S G D+ +H Sbjct: 243 -DDTHFVSSSSDKSVKVWDV-GTRTCVHTFFDHQDQVWGVKYNGNGSKIV-SVGDDQEIH 299 Query: 348 VWD 350 ++D Sbjct: 300 IYD 302 Score = 36.2 bits (82), Expect = 0.027, Method: Compositional matrix adjust. Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 5/78 (6%) Query: 293 LATGSADKTVALWDLRNLKLKLH-SFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 + TGS D V +W R+ +L L S E H+ + V S H I ASS D + +WDL Sbjct: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDIS-HTLPIAASSSLDAHIRLWDL 93 Query: 352 SKIGEEQSTEDAEDGPPE 369 G++ + DA GP + Sbjct: 94 EN-GKQIKSIDA--GPVD 108 >4XFV-A nrPDB Length = 792 Score = 37.0 bits (84), Expect = 0.015, Method: Compositional matrix adjust. Identities = 52/227 (22%), Positives = 96/227 (42%), Gaps = 29/227 (12%) Query: 205 TICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNN 264 TI LWD P E GH A V V + + S ++D + IW + Sbjct: 41 TIALWD----PIEPNNKGVYATLKGHEAEVTCVRF-VPDSDFMVSASEDHHVKIWKFTDY 95 Query: 265 NTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW--DLRNLKLKL-HSFESHK 321 + + T+ ++ + LS P +++ G AD T+++W +++N + L H F K Sbjct: 96 SHLQCIQTIQHYSKTIVALSALPS---LISVGCADGTISIWRQNIQNDEFGLAHEFTIKK 152 Query: 322 DEIFQVQWS----PHNETILASSGTDRRLHV--WDLSKIGEEQSTEDAEDGPPELLFIHG 375 + + S + +LA GT+ + + + LS G E+ AE Sbjct: 153 GFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAE---------LE 203 Query: 376 GHTAKISDFSWNPNEP---WIICSVSEDNIMQVWQMAENVYNDEEPE 419 GH + ++ E +++CS S+D +++W++ N D+ E Sbjct: 204 GHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEE 250 >5MWJ-A nrPDB Length = 337 Score = 37.0 bits (84), Expect = 0.016, Method: Compositional matrix adjust. Identities = 35/140 (25%), Positives = 56/140 (40%), Gaps = 16/140 (11%) Query: 197 LLSASDDHTICLWDINA-TPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 255 L+ + T+ +WD+ A TP+ + + A+ D + S D Sbjct: 112 LIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPD-------SKVCFSCCSDGN 164 Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR-NLKLKL 314 + +WD N + HT +C+ + L TG D TV WDLR +L+ Sbjct: 165 IAVWDLHNQTLVR---QFQGHTDGASCIDIS-NDGTKLWTGGLDNTVRSWDLREGRQLQQ 220 Query: 315 HSFESHKDEIFQVQWSPHNE 334 H F S +IF + + P E Sbjct: 221 HDFTS---QIFSLGYCPTGE 237 >5WLC-LO nrPDB Length = 923 Score = 36.6 bits (83), Expect = 0.023, Method: Compositional matrix adjust. Identities = 50/234 (21%), Positives = 94/234 (40%), Gaps = 52/234 (22%) Query: 175 LRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDIN-----ATPKEHR---------- 219 L+ +GH L+++P+ +++AS+D I +WDI AT +EH Sbjct: 339 LKQQGHFDSTNSLAYSPD-GSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAK 397 Query: 220 ------------------VIDAKNI--FTGHTAVVEDVAWHLLHESLFGSVA-----DDQ 254 +I +N FTG E + ++ L G V D+ Sbjct: 398 RGQVMFSSSLDGTVRAWDLIRYRNFRTFTG----TERIQFNCLAVDPSGEVVCAGSLDNF 453 Query: 255 KLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL 314 + +W + T + + H V+CLSF+ + +LA+ S DKT+ +W + ++ Sbjct: 454 DIHVWSVQ---TGQLLDALSGHEGPVSCLSFSQENS-VLASASWDKTIRIWSIFGRSQQV 509 Query: 315 HSFESHKDEIFQVQWSPHNETILASS--GTDRRLHVWDLSKIGEEQSTEDAEDG 366 E + D + + P + + S+ G ++ D ++G +D G Sbjct: 510 EPIEVYSD-VLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISG 562 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 30/155 (19%), Positives = 68/155 (43%), Gaps = 16/155 (10%) Query: 255 KLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVAL-WDLRNLKLK 313 ++ ++D NN + + H + + N +++ + + + + RN+ Sbjct: 36 RVSVFDLINNKSFTFEY---EHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNV--- 89 Query: 314 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFI 373 LH F + K++ V++SP +SG R L +W + +D + P + Sbjct: 90 LHHF-NFKEKCSAVKFSPDGRLFALASG--RFLQIWKTPDV-----NKDRQFAPFVRHRV 141 Query: 374 HGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 H GH I+ +W+ + +I+ + S+D ++W + Sbjct: 142 HAGHFQDITSLTWSQDSRFILTT-SKDLSAKIWSV 175 >5A9Q-2 nrPDB Length = 326 Score = 35.8 bits (81), Expect = 0.032, Method: Compositional matrix adjust. Identities = 48/232 (20%), Positives = 87/232 (37%), Gaps = 31/232 (13%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 L GH GL ++P + S SDDHT +W++ H V+ + + Sbjct: 120 LEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLHSPGM---------S 170 Query: 237 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATG 296 V WH E F + ++ I R + + + +V +S + + G Sbjct: 171 VCWH--PEETFKLMVAEKNGTI---RFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVG 225 Query: 297 S-ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHV-WDLSKI 354 + A +WD+ + H D +WS +E + A++G ++ + + + Sbjct: 226 AVAGNDWLIWDITRSSYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKMASQFQIHHL 285 Query: 355 GEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 G Q P L+ G A S SW+ P +C + D+ + W Sbjct: 286 GHPQ---------PILM----GSVAVGSGLSWHRTLP--LCVIGGDHKLLFW 322 Score = 32.3 bits (72), Expect = 0.43, Method: Compositional matrix adjust. Identities = 38/133 (28%), Positives = 62/133 (46%), Gaps = 20/133 (15%) Query: 221 IDAKNIFTGHTAV-VEDVAW--HLLHESL-----FGSVADDQKLMIW--DTRNNNTSKPS 270 I K + T H V V+ +AW +SL F + A D K+ ++ D ++ N K Sbjct: 61 IQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYK-- 118 Query: 271 HTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK---LKLH----SFESHKDE 323 ++ HT +N L F+P +A+ S D T +W+L ++ LH S H +E Sbjct: 119 -VLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLHSPGMSVCWHPEE 177 Query: 324 IFQVQWSPHNETI 336 F++ + N TI Sbjct: 178 TFKLMVAEKNGTI 190 >4U1E-I nrPDB Length = 347 Score = 35.8 bits (81), Expect = 0.034, Method: Compositional matrix adjust. Identities = 23/83 (27%), Positives = 43/83 (51%), Gaps = 5/83 (6%) Query: 227 FTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFN 286 TGH + V ++ + LF S + D +W + N + T+D HT + + + Sbjct: 6 LTGHERPLTQVKYNKEGDLLF-SCSKDSSASVWYSLNG---ERLGTLDGHTGTIWSIDVD 61 Query: 287 PYSEFILATGSADKTVALWDLRN 309 ++++ + TGSAD ++ LWD+ N Sbjct: 62 CFTKYCV-TGSADYSIKLWDVSN 83 >5I2T-A nrPDB Length = 742 Score = 35.8 bits (81), Expect = 0.037, Method: Compositional matrix adjust. Identities = 50/234 (21%), Positives = 94/234 (40%), Gaps = 52/234 (22%) Query: 175 LRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDIN-----ATPKEHR---------- 219 L+ +GH L+++P+ +++AS+D I +WDI AT +EH Sbjct: 364 LKQQGHFDSTNSLAYSPD-GSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAK 422 Query: 220 ------------------VIDAKNI--FTGHTAVVEDVAWHLLHESLFGSVA-----DDQ 254 +I +N FTG E + ++ L G V D+ Sbjct: 423 RGQVMFSSSLDGTVRAWDLIRYRNFRTFTG----TERIQFNCLAVDPSGEVVCAGSLDNF 478 Query: 255 KLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL 314 + +W + T + + H V+CLSF+ + +LA+ S DKT+ +W + ++ Sbjct: 479 DIHVWSVQ---TGQLLDALSGHEGPVSCLSFSQENS-VLASASWDKTIRIWSIFGRSQQV 534 Query: 315 HSFESHKDEIFQVQWSPHNETILASS--GTDRRLHVWDLSKIGEEQSTEDAEDG 366 E + D + + P + + S+ G ++ D ++G +D G Sbjct: 535 EPIEVYSD-VLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISG 587 Score = 33.5 bits (75), Expect = 0.16, Method: Compositional matrix adjust. Identities = 34/173 (19%), Positives = 73/173 (42%), Gaps = 23/173 (13%) Query: 255 KLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK- 313 ++ ++D NN + + H + + N +++ + + L N K + Sbjct: 61 RVSVFDLINNKSFTFEY---EHRKNIAAIDLNKQGTLLISIDEDGRAI----LVNFKARN 113 Query: 314 -LHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLF 372 LH F + K++ V++SP +SG R L +W + +D + P Sbjct: 114 VLHHF-NFKEKCSAVKFSPDGRLFALASG--RFLQIWKTPDV-----NKDRQFAPFVRHR 165 Query: 373 IHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASEL 425 +H GH I+ +W+ + +I+ + S+D ++W + + EE + A+ Sbjct: 166 VHAGHFQDITSLTWSQDSRFIL-TTSKDLSAKIWSV-----DSEEKNLAATTF 212 >5WLC-LW nrPDB Length = 554 Score = 35.0 bits (79), Expect = 0.060, Method: Compositional matrix adjust. Identities = 17/40 (42%), Positives = 28/40 (70%), Gaps = 2/40 (5%) Query: 280 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES 319 VN ++ + S + +AT AD+++ +WD+RN K +LHS ES Sbjct: 277 VNSIAID-RSGYYMATTGADRSMKIWDIRNFK-QLHSVES 314 >3JZG-A nrPDB Length = 402 Score = 35.0 bits (79), Expect = 0.060, Method: Compositional matrix adjust. Identities = 19/86 (22%), Positives = 41/86 (47%), Gaps = 1/86 (1%) Query: 227 FTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFN 286 + GH + ++ +H +L SV+ D L +W+ + + V+ H EV ++ Sbjct: 147 YVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYD 206 Query: 287 PYSEFILATGSADKTVALWDLRNLKL 312 E I++ G D ++ LW + + ++ Sbjct: 207 LLGEKIMSCG-MDHSLKLWRINSKRM 231 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 49/212 (23%), Positives = 81/212 (38%), Gaps = 47/212 (22%) Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 GH L ++P LLS S DH + LW+I + ++ GH V Sbjct: 149 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNI----QTDTLVAIFGGVEGHRDEVLSAD 204 Query: 239 WHLLHESLFGSVADDQKLMIW---------------DTRNNNTSKP----------SHTV 273 + LL E + S D L +W D N T++P T Sbjct: 205 YDLLGEKIM-SCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTR 263 Query: 274 DAHTAEVNCLSFNPYSEFILATGSADKTVALW-------DLRNLK------LKLHSFESH 320 D H V+C+ + + IL+ S + + W D+ +K L F+ Sbjct: 264 DIHRNYVDCVRW--LGDLILSK-SCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYS 320 Query: 321 KDEIFQVQWSPHN-ETILASSGTDRRLHVWDL 351 + +I+ +++S + +LA +L+VWDL Sbjct: 321 QCDIWYMRFSMDFWQKMLALGNQVGKLYVWDL 352 Score = 28.9 bits (63), Expect = 4.2, Method: Compositional matrix adjust. Identities = 10/33 (30%), Positives = 23/33 (69%) Query: 376 GHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 GH I++ ++P +P ++ SVS+D+ +++W + Sbjct: 149 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNI 181 >1PI6-A nrPDB Length = 615 Score = 35.0 bits (79), Expect = 0.062, Method: Compositional matrix adjust. Identities = 25/108 (23%), Positives = 53/108 (49%), Gaps = 17/108 (15%) Query: 255 KLMIWD--TRNNNTSKPSHTVDAHTAEVNCLSFNP---------YSEFILATGSADKTVA 303 K++++D +R TS+ + T+++N +S+ P E ++ATGS D + Sbjct: 511 KILLYDLQSREVKTSRWAF----RTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIF 566 Query: 304 LWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 ++ ++ + + +HKD + + W + L SSG D + W++ Sbjct: 567 IYSVKRPMKIIKALNAHKDGVNNLLW--ETPSTLVSSGADACIKRWNV 612 >5WYJ-BE nrPDB Length = 939 Score = 34.7 bits (78), Expect = 0.090, Method: Compositional matrix adjust. Identities = 34/159 (21%), Positives = 72/159 (45%), Gaps = 9/159 (5%) Query: 263 NNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES-HK 321 N K T+ + ++ LSF L+ G++ + +DL + + ++H ++ H+ Sbjct: 234 NMRKGKRIRTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDL-DRRSRIHVLKNIHR 292 Query: 322 DEIFQVQWSP--HNETILASSGTDRRL--HVWDLSKIGEEQSTEDAEDGPPELLFIHGGH 377 + V + + + I+ +SG D L +V+D S Q + D PP L GGH Sbjct: 293 ESYGGVTQATFLNGQPIIVTSGGDNSLKEYVFDPSL---SQGSGDVVVQPPRYLRSRGGH 349 Query: 378 TAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDE 416 + S ++ ++ + S S+D + + + ++ + E Sbjct: 350 SQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQE 388 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 68/339 (20%), Positives = 135/339 (39%), Gaps = 79/339 (23%) Query: 129 GEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGEC--QPDLRLR---GHQKE 183 G V +A ++ ++ T D + +Y PS + SG+ QP LR GH + Sbjct: 296 GGVTQATFLNGQPIIV---TSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQP 352 Query: 184 GYGLSWNPNLNGYLLSASDDHTICLWDIN---------ATPKEHRVIDAKNI--FTGHTA 232 +++ + + ++LSAS D + LW + + + H+ D + T + Sbjct: 353 PSYIAFADSQSHFMLSASKDRS--LWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSK 410 Query: 233 VVEDVAWHLLH------ESLFGSVADDQKLMIWDTRNNNTSKPSH--TVDAHTAEV---N 281 E VA + + E++ + D++ WD RN + + T D V Sbjct: 411 FPEIVALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQ 470 Query: 282 CLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG 341 C +F FI GS++ ++ ++++++ L+ ++ HK + + N + S G Sbjct: 471 CGNFG----FI---GSSNGSITIYNMQSGILR-KKYKLHKRAVTGISLDGMNRK-MVSCG 521 Query: 342 TDRRLHVWDLSK---IGEEQSTEDAEDGPPELLFIHG----------------------- 375 D + +D +K +G+ + D P + H Sbjct: 522 LDGIVGFYDFNKSTLLGKLKL-----DAPITAMVYHRSSDLFALALDDLSIVVIDAVTQR 576 Query: 376 ------GHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 GH+ +I+ F ++P WI+ S S D+ ++ W + Sbjct: 577 VVRQLWGHSNRITAFDFSPEGRWIV-SASLDSTIRTWDL 614 >2P9P-C nrPDB Length = 372 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 20/79 (25%), Positives = 34/79 (43%), Gaps = 13/79 (16%) Query: 312 LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELL 371 +++H + H ++ V W+P + I+ + GTDR +VW L P L+ Sbjct: 43 VQVHELKEHNGQVTGVDWAPDSNRIV-TCGTDRNAYVWTL----------KGRTWKPTLV 91 Query: 372 FIHGGHTAKISDFSWNPNE 390 + A+ W PNE Sbjct: 92 ILRINRAARC--VRWAPNE 108 >5YZG-2 nrPDB Length = 646 Score = 33.9 bits (76), Expect = 0.16, Method: Compositional matrix adjust. Identities = 36/158 (22%), Positives = 65/158 (41%), Gaps = 33/158 (20%) Query: 196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 255 ++++AS D + W K I+ F H V+E +A +LF SV DD+ Sbjct: 103 FIITASHDGHVKFWK-----KIEEGIEFVKHFRSHLGVIESIAVSS-EGALFCSVGDDKA 156 Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPY---SEFILATGSADKTVA--------- 303 + ++D N + +N L + E+I G A +VA Sbjct: 157 MKVFDVVNFDM-------------INMLKLGYFPGQCEWIYCPGDAISSVAASEKSTGKI 203 Query: 304 -LWDLRNLKLKLHSFES-HKDEIFQVQWSPHNETILAS 339 ++D R LH F+ H + Q++ +P + +++S Sbjct: 204 FIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSS 241 >5FVM-C nrPDB Length = 303 Score = 33.5 bits (75), Expect = 0.19, Method: Compositional matrix adjust. Identities = 50/207 (24%), Positives = 82/207 (39%), Gaps = 61/207 (29%) Query: 194 NGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADD 253 N +++S+S+D TI +WD+ +P R H A V +VA H L S D Sbjct: 87 NRWMVSSSEDGTIKVWDVR-SPSVQRNYK-------HNAPVNEVAIHPNQGELI-SCDQD 137 Query: 254 QKLMIWDTRNNNTSK------------------------------------PSHTVDAHT 277 + IWD N + P HT DA T Sbjct: 138 GNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHT-DAST 196 Query: 278 AEVNCLSFNPYSEFI-----------LATGSADKTVALWDLR-NLKLKLHSFESHKDEIF 325 E F ++++I LAT SAD T +W++ N +L+ + + H+ ++ Sbjct: 197 LE-PVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDNYQLET-TLDGHQRWVW 254 Query: 326 QVQWSPHNETILASSGTDRRLHVWDLS 352 +S + L ++ +D + +WDLS Sbjct: 255 DCAFSA-DSAYLVTACSDHYVRLWDLS 280 Score = 28.1 bits (61), Expect = 8.4, Method: Compositional matrix adjust. Identities = 13/43 (30%), Positives = 27/43 (62%), Gaps = 1/43 (2%) Query: 172 QPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINAT 214 Q + L GHQ+ + +++ + + YL++A DH + LWD++ + Sbjct: 241 QLETTLDGHQRWVWDCAFSAD-SAYLVTACSDHYVRLWDLSTS 282 >5WBU-D nrPDB Length = 328 Score = 33.5 bits (75), Expect = 0.19, Method: Compositional matrix adjust. Identities = 38/181 (20%), Positives = 69/181 (38%), Gaps = 18/181 (9%) Query: 249 SVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 308 + A Q + ++D +NN P + D + + F+ ++ TG D T +WDLR Sbjct: 60 AAAGYQHIRMYDLNSNN-PNPIISYDGVNKNIASVGFHEDGRWMY-TGGEDCTARIWDLR 117 Query: 309 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPP 368 + L+ I V P N+ L +H+WDL EQ + E Sbjct: 118 SRNLQCQRIFQVNAPINCVCLHP-NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPE---- 172 Query: 369 ELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETN 428 I+ +P+ ++ S N VW + + ++ IP +++ + Sbjct: 173 ----------VSITSAHIDPDASYMAAVNSTGNCY-VWNLTGGIGDEVTQLIPKTKIPAH 221 Query: 429 T 429 T Sbjct: 222 T 222 Score = 29.6 bits (65), Expect = 2.6, Method: Compositional matrix adjust. Identities = 21/67 (31%), Positives = 29/67 (43%), Gaps = 11/67 (16%) Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 305 L G + D+ +I P + AHT F+P S +LAT SAD+T +W Sbjct: 201 LTGGIGDEVTQLI----------PKTKIPAHTRYALQCRFSPDST-LLATCSADQTCKIW 249 Query: 306 DLRNLKL 312 N L Sbjct: 250 RTSNFSL 256 >4MDV-A nrPDB Length = 375 Score = 33.5 bits (75), Expect = 0.21, Method: Compositional matrix adjust. Identities = 17/44 (38%), Positives = 27/44 (61%), Gaps = 1/44 (2%) Query: 39 VMTHALEWPSLTAQWLPDVTKQDG-KDYSVHRLILGTHTSDEQN 81 V+ +A++ PSL A+WL D G KDY++ RL++ D Q+ Sbjct: 283 VLRYAIDRPSLIAEWLHDSMAGLGTKDYALMRLLITRSEIDLQD 326 >5TF2-A nrPDB Length = 407 Score = 33.1 bits (74), Expect = 0.26, Method: Compositional matrix adjust. Identities = 19/59 (32%), Positives = 32/59 (54%), Gaps = 3/59 (5%) Query: 292 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWD 350 +LATG D V +W + +L+ K+ F++H+ EI + P + L + G D + VW Sbjct: 186 LLATGGTDGYVRVWKVPSLE-KVLEFKAHEGEIEDLALGPDGK--LVTVGRDLKASVWQ 241 Score = 30.0 bits (66), Expect = 2.3, Method: Compositional matrix adjust. Identities = 21/86 (24%), Positives = 35/86 (40%), Gaps = 16/86 (18%) Query: 322 DEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKI 381 D + +V H+ T+LA+ GTD + VW + + E + H +I Sbjct: 172 DPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSL--------------EKVLEFKAHEGEI 217 Query: 382 SDFSWNPNEPWIICSVSEDNIMQVWQ 407 D + P+ + +V D VWQ Sbjct: 218 EDLALGPDGKLV--TVGRDLKASVWQ 241 >3I2N-A nrPDB Length = 357 Score = 33.1 bits (74), Expect = 0.27, Method: Compositional matrix adjust. Identities = 24/94 (25%), Positives = 44/94 (46%), Gaps = 7/94 (7%) Query: 318 ESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED------GPPELL 371 ++HK ++QV+ P N + ++G LH+W + ++S +D+E G LL Sbjct: 256 KAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKY-EYPIQRSKKDSEGIEMGVAGSVSLL 314 Query: 372 FIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQV 405 T IS W+P++ + S D ++V Sbjct: 315 QNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRV 348 >4OWR-A nrPDB Length = 339 Score = 32.7 bits (73), Expect = 0.30, Method: Compositional matrix adjust. Identities = 33/124 (26%), Positives = 53/124 (42%), Gaps = 18/124 (14%) Query: 191 PNLNG-YLLSASDDHTICLWDIN----ATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 P L G +L++ S + + W++ PK ++ HT V DV W Sbjct: 21 PTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQM---------HTGPVLDVCWSDDGSK 71 Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 305 +F + D M WD +N + + DA ++ + YS + TGS DKT+ W Sbjct: 72 VFTASCDKTAKM-WDLSSNQAIQIAQH-DAPVKTIHWIKAPNYS--CVMTGSWDKTLKFW 127 Query: 306 DLRN 309 D R+ Sbjct: 128 DTRS 131 >4UPL-A nrPDB Length = 569 Score = 32.7 bits (73), Expect = 0.33, Method: Compositional matrix adjust. Identities = 36/130 (27%), Positives = 56/130 (43%), Gaps = 19/130 (14%) Query: 145 ATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDH 204 AT+ D LV P+ E +G +P + H EG L P L+G DH Sbjct: 379 ATRGSVCDALVESIDLAPTFVEAAG-GKPAM----HILEGESLI--PILHGARDHTLRDH 431 Query: 205 TICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNN 264 IC +D +A+P H ++ ++ +V D W L+H D + M++D +N+ Sbjct: 432 VICEYDFSASPIAH--LNDISVRQAVMFMVADKNWKLIH------FEADPRPMLFDLKND 483 Query: 265 NTSKPSHTVD 274 P VD Sbjct: 484 ----PQELVD 489 >5WYK-BB nrPDB Length = 943 Score = 32.3 bits (72), Expect = 0.38, Method: Compositional matrix adjust. Identities = 30/111 (27%), Positives = 48/111 (43%), Gaps = 15/111 (13%) Query: 197 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 256 L+S S D I +WD+ +++ K+ TG ED W + S + D + Sbjct: 136 LISGSKDSNIIVWDLVGEVGLYKLRSHKDSITGFWCQGED--WLI-------STSKDGMI 186 Query: 257 MIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL 307 +WD + T + T AHT E C + ++ TG+ D V +W L Sbjct: 187 KLWDLK---THQCIETHIAHTGE--CWGLAVKDDLLITTGT-DSQVKIWKL 231 Score = 32.3 bits (72), Expect = 0.40, Method: Compositional matrix adjust. Identities = 39/165 (23%), Positives = 67/165 (40%), Gaps = 12/165 (7%) Query: 197 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 256 L++ S D T+ WD + V KN F + D L + L V+ D + Sbjct: 488 LVTGSADKTVKFWDFKV--ENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRY 545 Query: 257 MIWDTRNN-------NTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 309 + +N ++ K ++ H V + + S+ I+ T SADK + +W L + Sbjct: 546 LAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMII-TSSADKNIKIWGL-D 603 Query: 310 LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKI 354 S +H+D I V++ P + + S D + WD K Sbjct: 604 FGDCHKSLFAHQDSIMNVKFLPQSHNFFSCS-KDAVVKYWDGEKF 647 Score = 29.6 bits (65), Expect = 2.9, Method: Compositional matrix adjust. Identities = 22/61 (36%), Positives = 28/61 (45%), Gaps = 9/61 (14%) Query: 256 LMIWDTRNN--------NTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL 307 L+I TRN ++S DAH A + L + L TGSADKTV WD Sbjct: 444 LVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKR-LVTGSADKTVKFWDF 502 Query: 308 R 308 + Sbjct: 503 K 503 >5A9Q-7 nrPDB Length = 360 Score = 32.3 bits (72), Expect = 0.40, Method: Compositional matrix adjust. Identities = 20/62 (32%), Positives = 36/62 (58%), Gaps = 5/62 (8%) Query: 293 LATGSADKTVALWDLRNLKLKLH---SFESHKDEIFQVQWS-PHNETILASSGTDRRLHV 348 +AT S+D++V +WD ++ H S+++H +++V W+ P +LAS DR V Sbjct: 27 MATCSSDQSVKVWD-KSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAAV 85 Query: 349 WD 350 W+ Sbjct: 86 WE 87 Score = 31.2 bits (69), Expect = 0.85, Method: Compositional matrix adjust. Identities = 30/142 (21%), Positives = 66/142 (46%), Gaps = 16/142 (11%) Query: 223 AKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNC 282 A++I H ++ DV++ H + + DQ + +WD + + + H+ V Sbjct: 4 ARSIAADHKDLIHDVSFDF-HGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62 Query: 283 LSFNPYSEF--ILATGSADKTVALWD---------LRNLK--LKLHSFESHKDEIFQVQW 329 +++ + EF +LA+ S D+T A+W+ LR +K + + + V++ Sbjct: 63 VTW-AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKF 121 Query: 330 SP-HNETILASSGTDRRLHVWD 350 +P H +LA+ D + +++ Sbjct: 122 APKHMGLMLATCSADGIVRIYE 143 Score = 30.0 bits (66), Expect = 2.0, Method: Compositional matrix adjust. Identities = 20/88 (22%), Positives = 40/88 (45%), Gaps = 15/88 (17%) Query: 265 NTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH---SFESHK 321 N + H + T +V + P + + ++G K ++H F++H Sbjct: 230 NLGRSFHILAIATKDVRIFTLKPVRKELTSSGGP-----------TKFEIHIVAQFDNHN 278 Query: 322 DEIFQVQWSPHNETILASSGTDRRLHVW 349 ++++V W+ T+LASSG D + +W Sbjct: 279 SQVWRVSWNI-TGTVLASSGDDGCVRLW 305 >6CB1-s nrPDB Length = 569 Score = 32.0 bits (71), Expect = 0.49, Method: Compositional matrix adjust. Identities = 20/72 (27%), Positives = 35/72 (48%), Gaps = 1/72 (1%) Query: 337 LASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICS 396 LA +L++ S I E S +D P I+ GH K+ S +P+ W + + Sbjct: 158 LAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLW-LAT 216 Query: 397 VSEDNIMQVWQM 408 S+D ++VW++ Sbjct: 217 GSDDGTVRVWEI 228 Score = 29.6 bits (65), Expect = 2.9, Method: Compositional matrix adjust. Identities = 15/33 (45%), Positives = 20/33 (60%), Gaps = 1/33 (3%) Query: 275 AHTAEVNCLSFNPYSEFILATGSADKTVALWDL 307 H +V LS +P S LATGS D TV +W++ Sbjct: 197 GHKGKVRTLSIDP-SGLWLATGSDDGTVRVWEI 228 >5CXB-B nrPDB Length = 369 Score = 32.0 bits (71), Expect = 0.49, Method: Compositional matrix adjust. Identities = 33/118 (27%), Positives = 52/118 (44%), Gaps = 10/118 (8%) Query: 293 LATGSADKTVALW---DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 L GS DK + LW DL N K F H + I V++ + A + D L ++ Sbjct: 257 LVVGSYDKRL-LWHDLDLSNRPYKTMRF--HTEAIRAVRFHKGGLPLFADASDDGSLQIF 313 Query: 350 DLSKIGEEQSTEDAEDGPPELLFIHGG-HTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 K+ +Q E+ P ++L H + + D W+P EPW + S D ++W Sbjct: 314 H-GKVPNDQ-LENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWCV-SAGADGTARLW 368 Score = 31.6 bits (70), Expect = 0.74, Method: Compositional matrix adjust. Identities = 23/77 (29%), Positives = 41/77 (53%), Gaps = 5/77 (6%) Query: 275 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE-IFQVQWSPHN 333 H V ++ +P + LATG D TV +W+L + ++ S + + DE + V+W P Sbjct: 19 GHEGRVRSVAIDP-TGVALATGGDDGTVRVWELLTGR-QVWSVKLNGDEAVNTVRWRPTK 76 Query: 334 ETIL--ASSGTDRRLHV 348 +T + A++G D L + Sbjct: 77 DTFILAAAAGEDIFLMI 93 >6C0F-s nrPDB Length = 807 Score = 32.0 bits (71), Expect = 0.55, Method: Compositional matrix adjust. Identities = 20/72 (27%), Positives = 35/72 (48%), Gaps = 1/72 (1%) Query: 337 LASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICS 396 LA +L++ S I E S +D P I+ GH K+ S +P+ W + + Sbjct: 396 LAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLW-LAT 454 Query: 397 VSEDNIMQVWQM 408 S+D ++VW++ Sbjct: 455 GSDDGTVRVWEI 466 Score = 29.6 bits (65), Expect = 2.6, Method: Compositional matrix adjust. Identities = 15/33 (45%), Positives = 20/33 (60%), Gaps = 1/33 (3%) Query: 275 AHTAEVNCLSFNPYSEFILATGSADKTVALWDL 307 H +V LS +P S LATGS D TV +W++ Sbjct: 435 GHKGKVRTLSIDP-SGLWLATGSDDGTVRVWEI 466 >6EM1-m nrPDB Length = 807 Score = 32.0 bits (71), Expect = 0.59, Method: Compositional matrix adjust. Identities = 20/72 (27%), Positives = 35/72 (48%), Gaps = 1/72 (1%) Query: 337 LASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICS 396 LA +L++ S I E S +D P I+ GH K+ S +P+ W + + Sbjct: 396 LAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLW-LAT 454 Query: 397 VSEDNIMQVWQM 408 S+D ++VW++ Sbjct: 455 GSDDGTVRVWEI 466 >5N4A-A nrPDB Length = 771 Score = 31.2 bits (69), Expect = 0.94, Method: Compositional matrix adjust. Identities = 50/242 (20%), Positives = 81/242 (33%), Gaps = 80/242 (33%) Query: 197 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES--------LFG 248 L + SDD TI W++ P E +V FT D+ W+ + +F Sbjct: 28 LFTCSDDQTIHKWNMLGEP-EQKVSTLDAYFT-------DMHWYPVSSKKTQAGGTDVFA 79 Query: 249 SVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFN-PYSEFILATGSADKTVALWDL 307 D + I + T + +++ H C+S Y LAT D +V +W Sbjct: 80 VACTDGSVKIL----SRTGRVEKSIEGHKGA--CISLRWSYDGTALATAGEDGSVKIWS- 132 Query: 308 RNLKL----------------------------------------KLHSFESHKDEIFQV 327 RN L K +++++H + +V Sbjct: 133 RNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIKSLSSNAKQNAWKAHDGVVLKV 192 Query: 328 QWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWN 387 WSP N I+ + G D + VW D LLF G ++ +W Sbjct: 193 DWSPINHLII-TGGEDCKYKVW---------------DSFGRLLFQSGLFDYPVTSVAWA 236 Query: 388 PN 389 P+ Sbjct: 237 PS 238 >3F3P-A nrPDB Length = 351 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 33/135 (24%), Positives = 63/135 (46%), Gaps = 14/135 (10%) Query: 228 TGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTS-KPSHTVDAHTAEVNCLSF- 285 +GH +V DV + + + + DQ + ++ + ++ + S + AH + + + + Sbjct: 8 SGHDDLVHDVVYDFYGRHV-ATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWA 66 Query: 286 NPYSEFILATGSADKTVALWD---------LRNLKLKLHSFESHKDEIFQVQWSP-HNET 335 +P I+A+ S DKTV LW+ R KL + K ++ V+++P H Sbjct: 67 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWN-KLCTLNDSKGSLYSVKFAPAHLGL 125 Query: 336 ILASSGTDRRLHVWD 350 LA G D L ++D Sbjct: 126 KLACLGNDGILRLYD 140 >5M89-A nrPDB Length = 329 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 14/70 (20%), Positives = 28/70 (40%) Query: 280 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS 339 + L+F+ + ATG +V ++DLR E E+ + W + + Sbjct: 215 IQALAFSENGFWFAATGKGTSSVTIFDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATG 274 Query: 340 SGTDRRLHVW 349 GT + ++ Sbjct: 275 GGTGVTVQMY 284 >5K0Y-T nrPDB Length = 329 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 24/86 (27%), Positives = 40/86 (46%), Gaps = 5/86 (5%) Query: 226 IFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSF 285 + GH + + ++ + LF +VA D + +W + N T HT V C+ Sbjct: 5 LLQGHERSITQIKYNREGDLLF-TVAKDPIVNVWYSVNGERLG---TYMGHTGAVWCVDA 60 Query: 286 NPYSEFILATGSADKTVALWDLRNLK 311 + ++ +L TGSAD + LWD K Sbjct: 61 DWDTKHVL-TGSADNSCRLWDCETGK 85 >6CVZ-A nrPDB Length = 351 Score = 29.3 bits (64), Expect = 3.3, Method: Compositional matrix adjust. Identities = 30/112 (26%), Positives = 50/112 (44%), Gaps = 16/112 (14%) Query: 180 HQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW 239 H K+ GL+++ L G LLSAS D+TI L + + + V+ N G V W Sbjct: 73 HGKQIRGLAFSSYLRGLLLSASLDNTIKLTSL----ETNTVVQTYN--AGRP--VWSCCW 124 Query: 240 HLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNC----LSFNP 287 L + + + ++++D RN + SH + + C LS+ P Sbjct: 125 CLDEANYIYAGLANGSILVYDVRNTS----SHVQELVAQKARCPLVSLSYMP 172 >4J0W-A nrPDB Length = 343 Score = 29.3 bits (64), Expect = 3.3, Method: Compositional matrix adjust. Identities = 38/166 (22%), Positives = 66/166 (39%), Gaps = 31/166 (18%) Query: 199 SASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMI 258 + D T+ +W I P+E +++ F GH ++ + HL++E S ADD + + Sbjct: 168 AGGRDGTVRVWKI---PEESQLV-----FYGHQGSIDCI--HLINEEHMVSGADDGSVAL 217 Query: 259 W---DTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEF----ILATGSADKTVALWD----L 307 W R + +H + + + ++ATGS V LW Sbjct: 218 WGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGF 277 Query: 308 RNLKL----KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 R L L L F I +++S + ++A G + RL W Sbjct: 278 RQLDLLCDIPLVGF------INSLKFSSSGDFLVAGVGQEHRLGRW 317 >4DI9-A nrPDB Length = 303 Score = 29.3 bits (64), Expect = 3.7, Method: Compositional matrix adjust. Identities = 12/43 (27%), Positives = 23/43 (53%), Gaps = 3/43 (6%) Query: 249 SVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEF 291 S+ +D++++ W N SKP +T + +C F P ++F Sbjct: 2 SLTNDERILSW---NETPSKPRYTPPPGAIDAHCHVFGPMAQF 41 >6BM8-A nrPDB Length = 833 Score = 28.9 bits (63), Expect = 4.7, Method: Compositional matrix adjust. Identities = 13/25 (52%), Positives = 16/25 (64%) Query: 272 TVDAHTAEVNCLSFNPYSEFILATG 296 TV+ EV+ S PY EF+LATG Sbjct: 197 TVNCIVEEVDARSVYPYDEFVLATG 221 >3ODT-A nrPDB Length = 313 Score = 28.5 bits (62), Expect = 5.2, Method: Compositional matrix adjust. Identities = 36/162 (22%), Positives = 61/162 (37%), Gaps = 41/162 (25%) Query: 271 HTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWS 330 + + AH A V +SE T SADKT+ LW D++ + Sbjct: 136 YNLQAHNASVWDAKVVSFSENKFLTASADKTIKLW--------------QNDKVIKTFSG 181 Query: 331 PHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNE 390 HN+ + R L V D + + DG +L+ +H G + ++ +E Sbjct: 182 IHNDVV-------RHLAVVD-----DGHFISCSNDGLIKLVDMHTGDVLR----TYEGHE 225 Query: 391 PWIIC----------SVSEDNIMQVWQMAENVYNDEEPEIPA 422 ++ C S ED +++W EN + +PA Sbjct: 226 SFVYCIKLLPNGDIVSCGEDRTVRIWS-KENGSLKQVITLPA 266 >3ISM-C nrPDB Length = 359 Score = 28.5 bits (62), Expect = 5.2, Method: Compositional matrix adjust. Identities = 41/194 (21%), Positives = 65/194 (33%), Gaps = 57/194 (29%) Query: 200 ASDDHTICLWD--------INATPKEHRVID---AKNIFTGHTAVVEDVAWHLLHESLFG 248 A +D+TI L D I + ++D K F A DV W LL + Sbjct: 21 AQNDYTIGLVDPVKDYQKLIETRVQVDEIVDDDVTKENFDRTAAAARDVIWRLLFDEA-- 78 Query: 249 SVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 308 T +NT K S ++ + + PY+E+I+ LR Sbjct: 79 -----------GTSQSNTEKASQLLEEYRGDACFYDPTPYNEWIVK------------LR 115 Query: 309 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPP 368 + LK + +D + + Q P W + D++D PP Sbjct: 116 DEVLKKELLDFWRDVLVKKQLGP----------------CW-----SRDSDLFDSDDTPP 154 Query: 369 ELLFIHGGHTAKIS 382 + H G TA + Sbjct: 155 LEFYAHAGCTAPFA 168 >5AJA-A nrPDB Length = 361 Score = 28.5 bits (62), Expect = 6.1, Method: Compositional matrix adjust. Identities = 24/95 (25%), Positives = 43/95 (45%), Gaps = 15/95 (15%) Query: 258 IWDTRNNNTSKPSHTVD-AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 316 I+D + N D A+ + NC +FNP + +L G LWD+R+ + +H Sbjct: 146 IYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVLNDG------VLWDVRSAQ-AIHK 198 Query: 317 FESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 F+ I V + P+ ++ ++ +WDL Sbjct: 199 FDKFNMNISGV-FHPNGLEVIINT------EIWDL 226 >6CHG-A nrPDB Length = 312 Score = 28.1 bits (61), Expect = 7.8, Method: Compositional matrix adjust. Identities = 30/133 (22%), Positives = 57/133 (42%), Gaps = 14/133 (10%) Query: 175 LRLRGHQKEGYG-LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAV 233 ++L KE L W+P+ + + S S+D T+ H + GHTA Sbjct: 47 MKLTTTHKECINCLCWSPD-SKCIASGSEDFTV--------EITHIIYGRIRRLMGHTAP 97 Query: 234 VEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFIL 293 V + ++ ++ S + D+ + W + K T+ AH+ V + + IL Sbjct: 98 VISICYNN-KGNILCSSSMDESIKEWHVLSGTALK---TMSAHSDAVVSIDIPKFDSSIL 153 Query: 294 ATGSADKTVALWD 306 ++GS D + ++D Sbjct: 154 SSGSYDGLIRIFD 166 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3C9C-A nrPDB 609 e-175 5Y1U-A nrPDB 569 e-162 3CFV-B nrPDB 557 e-159 5WJC-A nrPDB 444 e-125 4XYI-A nrPDB 414 e-116 4PSX-B nrPDB 367 e-102 6MZM-G nrPDB 205 2e-53 4V6W-Ag nrPDB 204 6e-53 6HQA-B nrPDB 202 3e-52 3DM0-A nrPDB 202 3e-52 6F3T-A nrPDB 201 4e-52 5M25-A nrPDB 198 3e-51 6QX9-5O nrPDB 196 1e-50 2H9P-A nrPDB 193 1e-49 6G51-g nrPDB 190 7e-49 5MZH-A nrPDB 188 4e-48 6ID0-T nrPDB 186 1e-47 5NNZ-B nrPDB 180 1e-45 4V8M-A7 nrPDB 178 5e-45 5OPT-p nrPDB 175 3e-44 3FM0-A nrPDB 175 4e-44 5L9T-R nrPDB 174 6e-44 6QX9-4B nrPDB 174 7e-44 5FL8-q nrPDB 174 8e-44 1VYH-C nrPDB 168 5e-42 5G04-R nrPDB 167 1e-41 4V7E-Bg nrPDB 166 1e-41 4A11-B nrPDB 165 3e-41 5WYJ-BC nrPDB 165 4e-41 4GGA-A nrPDB 165 4e-41 3JRO-A nrPDB 164 5e-41 5Y88-O nrPDB 164 5e-41 5LCW-Q nrPDB 164 6e-41 3W15-A nrPDB 164 8e-41 6HHQ-h nrPDB 164 9e-41 5GAN-H nrPDB 162 3e-40 5NZU-C nrPDB 158 3e-39 4BTS-AR nrPDB 158 5e-39 6N9G-C nrPDB 158 5e-39 5A9Q-0 nrPDB 156 1e-38 3JAP-g nrPDB 156 2e-38 5YZG-W nrPDB 156 2e-38 6QDV-o nrPDB 156 2e-38 3JRP-A nrPDB 154 4e-38 4N14-A nrPDB 153 2e-37 4YCZ-A nrPDB 153 2e-37 5OQL-J nrPDB 150 9e-37 4BZK-B nrPDB 150 1e-36 3MKQ-A nrPDB 148 3e-36 2PM9-A nrPDB 147 7e-36 4L9O-A nrPDB 147 8e-36 5OQL-d nrPDB 146 1e-35 2YNP-A nrPDB 145 3e-35 2HES-X nrPDB 144 7e-35 3JB9-g nrPDB 144 8e-35 3JB9-L nrPDB 143 1e-34 5K1B-B nrPDB 136 1e-32 5UZ7-B nrPDB 136 2e-32 5A31-R nrPDB 134 7e-32 5Z56-q nrPDB 134 8e-32 4BH6-A nrPDB 131 4e-31 4LG8-A nrPDB 131 6e-31 5XYI-g nrPDB 126 1e-29 4AEZ-A nrPDB 126 2e-29 5FA5-B nrPDB 126 2e-29 6BX3-A nrPDB 124 6e-29 1NR0-A nrPDB 124 9e-29 6J6H-n nrPDB 122 3e-28 2AQ5-A nrPDB 122 3e-28 5WLC-LU nrPDB 122 3e-28 4G56-B nrPDB 119 3e-27 6EMK-B nrPDB 117 7e-27 6F1U-h nrPDB 114 7e-26 5OQL-L nrPDB 112 3e-25 6ELZ-p nrPDB 110 1e-24 5WLC-LJ nrPDB 107 1e-23 4E5Z-B nrPDB 79 3e-15 3EI3-B nrPDB 78 6e-15 6BX3-B nrPDB 72 6e-13 5WLC-LS nrPDB 57 2e-08 Sequences not found previously or not previously below threshold: 6EOJ-D nrPDB 136 2e-32 6Q8F-A nrPDB 129 2e-30 5WLC-LO nrPDB 127 1e-29 5I2T-A nrPDB 126 2e-29 5FVM-C nrPDB 121 7e-28 6CHG-A nrPDB 119 3e-27 3BG0-A nrPDB 116 2e-26 6GMH-W nrPDB 114 7e-26 4J0W-A nrPDB 112 2e-25 3ODT-A nrPDB 112 4e-25 5CXC-A nrPDB 111 4e-25 5A9Q-7 nrPDB 105 5e-23 5WYK-BB nrPDB 102 4e-22 3F3P-A nrPDB 101 1e-21 5WBU-D nrPDB 99 3e-21 5N4A-A nrPDB 95 7e-20 3I2N-A nrPDB 93 3e-19 4XFV-A nrPDB 93 3e-19 1PI6-A nrPDB 92 4e-19 5A9Q-2 nrPDB 92 5e-19 5BJS-A nrPDB 91 1e-18 4U1E-I nrPDB 88 8e-18 5WYJ-BE nrPDB 87 2e-17 5K0Y-T nrPDB 85 5e-17 5OQL-X nrPDB 85 5e-17 4OWR-A nrPDB 83 4e-16 5YZG-2 nrPDB 82 5e-16 3ACP-A nrPDB 81 7e-16 6CB1-s nrPDB 81 1e-15 6C0F-s nrPDB 81 1e-15 6EM1-m nrPDB 80 2e-15 3JZG-A nrPDB 78 1e-14 5M89-A nrPDB 76 3e-14 5MWJ-A nrPDB 75 5e-14 6E29-D nrPDB 74 1e-13 5CXB-B nrPDB 73 2e-13 3DW8-B nrPDB 73 2e-13 5K19-A nrPDB 72 6e-13 2P9P-C nrPDB 71 1e-12 4J0X-A nrPDB 69 3e-12 5WLC-SG nrPDB 68 7e-12 5OV3-A nrPDB 68 1e-11 5WLC-LN nrPDB 63 2e-10 5TF2-A nrPDB 63 2e-10 3JB9-S nrPDB 61 7e-10 3DWL-C nrPDB 61 1e-09 6CHG-D nrPDB 58 6e-09 5MC6-j nrPDB 57 1e-08 4FHN-A nrPDB 57 2e-08 5WLC-LW nrPDB 55 6e-08 6CVZ-A nrPDB 52 4e-07 5LTD-A nrPDB 52 4e-07 2VDU-B nrPDB 52 4e-07 6IYY-A nrPDB 47 1e-05 5WLC-LV nrPDB 47 2e-05 3WJ9-A nrPDB 46 4e-05 4AV8-A nrPDB 44 1e-04 2I3T-A nrPDB 42 3e-04 5WLC-LH nrPDB 41 8e-04 5AMS-A nrPDB 40 0.003 5K1H-B nrPDB 39 0.005 6N8P-A nrPDB 38 0.007 4YHC-A nrPDB 33 0.25 5CWW-B nrPDB 32 0.36 5BPW-A nrPDB 32 0.40 2YNZ-A nrPDB 32 0.41 5AJA-A nrPDB 32 0.47 4NOX-A nrPDB 32 0.58 5GRS-A nrPDB 32 0.68 5ODS-A nrPDB 32 0.69 4G55-A nrPDB 32 0.69 1BPO-A nrPDB 32 0.69 5HAX-A nrPDB 32 0.71 2PFR-A nrPDB 32 0.73 6FYY-p nrPDB 31 0.79 5BPT-A nrPDB 31 0.86 3LED-A nrPDB 31 0.87 4MDV-A nrPDB 31 1.1 4U1F-A nrPDB 31 1.5 2IJA-A nrPDB 31 1.6 3LV4-A nrPDB 30 1.8 1OI2-A nrPDB 30 2.8 4MOC-A nrPDB 29 2.9 >3C9C-A nrPDB Length = 432 Score = 609 bits (1571), Expect = e-175, Method: Composition-based stats. Identities = 430/430 (100%), Positives = 430/430 (100%) Query: 1 MVDRSDNAAESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQ 60 MVDRSDNAAESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQ Sbjct: 3 MVDRSDNAAESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQ 62 Query: 61 DGKDYSVHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIE 120 DGKDYSVHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIE Sbjct: 63 DGKDYSVHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIE 122 Query: 121 IEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGH 180 IEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGH Sbjct: 123 IEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGH 182 Query: 181 QKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH 240 QKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH Sbjct: 183 QKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH 242 Query: 241 LLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADK 300 LLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADK Sbjct: 243 LLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADK 302 Query: 301 TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 360 TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST Sbjct: 303 TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 362 Query: 361 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEI 420 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEI Sbjct: 363 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEI 422 Query: 421 PASELETNTA 430 PASELETNTA Sbjct: 423 PASELETNTA 432 >5Y1U-A nrPDB Length = 456 Score = 569 bits (1465), Expect = e-162, Method: Composition-based stats. Identities = 376/413 (91%), Positives = 401/413 (97%) Query: 7 NAAESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYS 66 + +FDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVT+ +GKD+S Sbjct: 34 DKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFS 93 Query: 67 VHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKIN 126 +HRL+LGTHTSDEQNHL+IASVQLP++DAQFD SHYD+EKGEFGGFGSV GKIEIEIKIN Sbjct: 94 IHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKIN 153 Query: 127 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 186 HEGEVNRARYMPQN C+IATKTPSSDVLVFDYTKHPSKP+PSGEC PDLRLRGHQKEGYG Sbjct: 154 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 213 Query: 187 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 246 LSWNPNL+G+LLSASDDHTICLWDI+A PKE +V+DAK IFTGHTAVVEDV+WHLLHESL Sbjct: 214 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 273 Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 FGSVADDQKLMIWDTR+NNTSKPSH+VDAHTAEVNCLSFNPYSEFILATGSADKTVALWD Sbjct: 274 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 333 Query: 307 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 366 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL+VWDLSKIGEEQS EDAEDG Sbjct: 334 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 393 Query: 367 PPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPE 419 PPELLFIHGGHTAKISDFSWNPNEPW+ICSVSEDNIMQVWQMAEN+YNDE+PE Sbjct: 394 PPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPE 446 Score = 85.6 bits (210), Expect = 4e-17, Method: Composition-based stats. Identities = 39/162 (24%), Positives = 68/162 (41%), Gaps = 16/162 (9%) Query: 276 HTAEVNCLSFNPYSEFILATGSADKTVALWDL--------RNLKL-KLHSFESHKDEIFQ 326 H EVN + P + I+AT + V ++D + + H+ E + Sbjct: 154 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 213 Query: 327 VQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSW 386 + W+P+ L S+ D + +WD+S + +E DA+ I GHTA + D SW Sbjct: 214 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAK-------TIFTGHTAVVEDVSW 266 Query: 387 NPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETN 428 + + SV++D + +W N + + A E N Sbjct: 267 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVN 308 >3CFV-B nrPDB Length = 414 Score = 557 bits (1434), Expect = e-159, Method: Composition-based stats. Identities = 355/409 (86%), Positives = 386/409 (94%) Query: 8 AAESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSV 67 + E F+D VEERVINEEYKIWKKNTPFLYDLVMTHAL+WPSLT QWLP+VTK +GKDY++ Sbjct: 6 SKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDYAL 65 Query: 68 HRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINH 127 H L+LGTHTSDEQNHL++A V +P++DAQFD SH D++KGEFGGFGSV GKIE EIKINH Sbjct: 66 HWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKINH 125 Query: 128 EGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGL 187 EGEVNRARYMPQN +IATKTPSSDVLVFDYTKHP+KP+PSGEC PDLRLRGHQKEGYGL Sbjct: 126 EGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGL 185 Query: 188 SWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLF 247 SWN NL+G+LLSASDDHT+CLWDINA PKE +++DAK IFTGH+AVVEDVAWHLLHESLF Sbjct: 186 SWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLF 245 Query: 248 GSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL 307 GSVADDQKLMIWDTR+N TSKPSH VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL Sbjct: 246 GSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL 305 Query: 308 RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGP 367 RNLKLKLH+FESHKDEIFQV WSPHNETILASSGTDRRL+VWDLSKIGEEQS EDAEDGP Sbjct: 306 RNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGP 365 Query: 368 PELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDE 416 PELLFIHGGHTAKISDFSWNPNEPW+ICSVSEDNIMQ+WQMAEN+YNDE Sbjct: 366 PELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDE 414 Score = 81.4 bits (199), Expect = 7e-16, Method: Composition-based stats. Identities = 35/162 (21%), Positives = 66/162 (40%), Gaps = 16/162 (9%) Query: 276 HTAEVNCLSFNPYSEFILATGSADKTVALWDL--------RNLKL-KLHSFESHKDEIFQ 326 H EVN + P + I+AT + V ++D + + H+ E + Sbjct: 125 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 184 Query: 327 VQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSW 386 + W+ + L S+ D + +WD++ +E DA+ I GH+A + D +W Sbjct: 185 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKA-------IFTGHSAVVEDVAW 237 Query: 387 NPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETN 428 + + SV++D + +W N + + A E N Sbjct: 238 HLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVN 279 >5WJC-A nrPDB Length = 430 Score = 444 bits (1142), Expect = e-125, Method: Composition-based stats. Identities = 209/416 (50%), Positives = 280/416 (67%), Gaps = 15/416 (3%) Query: 18 ERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRLILGTHTS 77 ++ I EEYK+WK+N PFLYDLV+THALEWPSLT QWLPD G DYS+ RLILGTHTS Sbjct: 23 QKTIQEEYKLWKQNVPFLYDLVITHALEWPSLTIQWLPDKKTIPGTDYSIQRLILGTHTS 82 Query: 78 -DEQNHLLIASVQLPSED---AQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNR 133 ++QN+L IASVQLP+ D +F S + G + IEI KI H+G+VNR Sbjct: 83 GNDQNYLQIASVQLPNFDEDTTEFTPSTIRRAQAT-GSY-----TIEISQKIPHDGDVNR 136 Query: 134 ARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNL 193 ARYMPQ +IAT + +FD T H + +GE P L+GH EG+GL WNPNL Sbjct: 137 ARYMPQKPEIIATMGEGGNAYIFDTTCHDALT--TGEALPQAVLKGHTAEGFGLCWNPNL 194 Query: 194 NGYLLSASDDHTICLWDINA---TPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSV 250 G L + ++D ICLWD+ T E +VI + HT +V DV +H HE+L SV Sbjct: 195 PGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASV 254 Query: 251 ADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 310 +DD L I DTR N + + AH+ +N ++ NP+++++LAT SADKTVALWDLRN Sbjct: 255 SDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDLRNP 314 Query: 311 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPEL 370 +LH+ E H+DE++ ++WSPH+E ILASS TDRR+ +WDL KIGEEQ+ EDAEDG PEL Sbjct: 315 YQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPEL 374 Query: 371 LFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELE 426 LF+HGGHT +IS+FSW PNE W++ S+++DNI+Q+W + ++ + ++ +LE Sbjct: 375 LFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIWSPSRVIWGRDHVQVSPRDLE 430 Score = 79.8 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 35/160 (21%), Positives = 63/160 (39%), Gaps = 11/160 (6%) Query: 276 HTAEVNCLSFNPYSEFILATGSADKTVALWDLR-------NLKLKLHSFESHKDEIFQVQ 328 H +VN + P I+AT ++D L + H E F + Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 329 WSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNP 388 W+P+ LA+ D+ + +WD+ + QS +E + + HT ++D ++P Sbjct: 190 WNPNLPGNLATGAEDQVICLWDV----QTQSFTSSETKVISPIAKYHRHTDIVNDVQFHP 245 Query: 389 NEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETN 428 ++ SVS+D +Q+ N + I A N Sbjct: 246 QHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAIN 285 >4XYI-A nrPDB Length = 430 Score = 414 bits (1065), Expect = e-116, Method: Composition-based stats. Identities = 197/434 (45%), Positives = 284/434 (65%), Gaps = 22/434 (5%) Query: 5 SDNAAESFDDAVE---ERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQD 61 S+N E + E E+ I EEYK+WK+N PFLYDLV+T ALEWPSLT +W P + Sbjct: 7 SENVEEEKQELSEVDLEKKIQEEYKLWKQNVPFLYDLVITEALEWPSLTVEWFPGSERSL 66 Query: 62 GKDYSVHRLILGTHTS-DEQNHLLIASVQLPSEDAQFDGSHYD-----NEKGEFGGFGSV 115 + S+ +L+LGT TS ++QN+L +ASVQLP+ D D N KG++G Sbjct: 67 ADNSSIQKLLLGTQTSGNDQNYLQVASVQLPTFDDDLDDLTPSKMKPANFKGDYG----- 121 Query: 116 CGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDL 175 ++I KI+HEG+VN+AR+MPQN +IAT + + +FD + + +P + Sbjct: 122 ---LDIVQKIHHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLY--REQPIVQTGHQA 176 Query: 176 RLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATP---KEHRVIDAKNIFTGHTA 232 LR H EG+GL WN G L + ++D +IC+WDI ++ + +++ HTA Sbjct: 177 CLRHHTSEGFGLGWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTA 236 Query: 233 VVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI 292 VV D+ +HL HE+L SV+DD L I DTR ++S S V AH VN ++FNP+++++ Sbjct: 237 VVNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYL 296 Query: 293 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLS 352 LAT SAD TVALWDLR L +LH+ E H+DE++ VQWSPH+E IL +S TDRR+ VWDLS Sbjct: 297 LATASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLS 356 Query: 353 KIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENV 412 KIGEEQ+ ED+EDG PEL+F+HGGHT ++SD SWNPN W++ S+++DNI+Q+W ++ + Sbjct: 357 KIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSKVI 416 Query: 413 YNDEEPEIPASELE 426 + + +I + +LE Sbjct: 417 WASDSLKIDSKDLE 430 Score = 64.4 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 37/160 (23%), Positives = 67/160 (41%), Gaps = 11/160 (6%) Query: 276 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEI-------FQVQ 328 H +VN F P + I+AT + ++DL + + H+ + F + Sbjct: 130 HEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLG 189 Query: 329 WSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNP 388 W+ E LA+ D + VWD+ G+ S E + D P ++ HTA ++D ++ Sbjct: 190 WNFIQEGTLATGTEDTSICVWDIK--GKSLSLEKSIDVAPVSVY--HRHTAVVNDLQFHL 245 Query: 389 NEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETN 428 ++ SVS+D +Q+ + + A E N Sbjct: 246 QHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVN 285 >4PSX-B nrPDB Length = 401 Score = 367 bits (943), Expect = e-102, Method: Composition-based stats. Identities = 141/393 (35%), Positives = 218/393 (55%), Gaps = 17/393 (4%) Query: 21 INEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRLILGTHTS-DE 79 ++EEY +WK N P +YD V L WPSLT QWLP ++ + LI+GTHTS +E Sbjct: 10 VDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELIIGTHTSGEE 69 Query: 80 QNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQ 139 +N+L A + LP E + + + + I I K HE E+ RARYMPQ Sbjct: 70 ENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQ 129 Query: 140 NACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLS 199 + ++AT ++ ++ Q L+ H+ GY LS++ + G LLS Sbjct: 130 DPNIVATINGQGTTFLYSRSEG---------LQSTLKF--HKDNGYALSFSTLVKGRLLS 178 Query: 200 ASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIW 259 SDDHT+ LW++ + + + N H+ ++ D WH ++ LFG+V++D L I Sbjct: 179 GSDDHTVALWEVGSGGDPTKPVRTWNDL--HSDIINDNKWHNFNKDLFGTVSEDSLLKIN 236 Query: 260 DTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES 319 D R NNT+ + N L+F+ +S +LA D V L+DLRN+K LH Sbjct: 237 DVRANNTTIDTVKC---PQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSG 293 Query: 320 HKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTA 379 H+D + +++S H + ++ SSG+D RL +WDL +IG EQ+ +DAEDG PEL+ +H GH + Sbjct: 294 HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRS 353 Query: 380 KISDFSWNPNEPWIICSVSEDNIMQVWQMAENV 412 ++DF NP PW++ S E+NI+QVW+ + ++ Sbjct: 354 SVNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 >6MZM-G nrPDB Length = 800 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 71/252 (28%), Positives = 112/252 (44%), Gaps = 30/252 (11%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 L GH YG S++P+ N YLLS+S+D T+ LW + + GH V D Sbjct: 539 LYGHSGPVYGASFSPDRN-YLLSSSEDGTVRLWSLQT-------FTCLVGYKGHNYPVWD 590 Query: 237 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATG 296 + F S D+ +W T + +P H A+VNC F+P + +ATG Sbjct: 591 TQFSPYG-YYFVSGGHDRVARLWAT---DHYQPLRIFAGHLADVNCTRFHP-NSNYVATG 645 Query: 297 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGE 356 SAD+TV LWD+ N + F HK I + +SP+ LA+ TD R+ +WD+ Sbjct: 646 SADRTVRLWDVLNGNC-VRIFTGHKGPIHSLTFSPNGR-FLATGATDGRVLLWDI----- 698 Query: 357 EQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDE 416 G ++ GHT + ++ + I+ S S DN +++W + + E Sbjct: 699 ---------GHGLMVGELKGHTDTVCSLRFSRDGE-ILASGSMDNTVRLWDAIKAFEDLE 748 Query: 417 EPEIPASELETN 428 + + N Sbjct: 749 TDDFTTATGHIN 760 Score = 132 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 47/216 (21%), Positives = 74/216 (34%), Gaps = 46/216 (21%) Query: 123 IKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPS------------------- 163 I H G V A + P + + + + V ++ Sbjct: 538 ILYGHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596 Query: 164 -------------KPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWD 210 + + QP GH + ++PN N Y+ + S D T+ LWD Sbjct: 597 GYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN-YVATGSADRTVRLWD 655 Query: 211 INATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPS 270 + IFTGH + + + + A D ++++WD Sbjct: 656 VLNGN-------CVRIFTGHKGPIHSLTFSPNGR-FLATGATDGRVLLWDI---GHGLMV 704 Query: 271 HTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 + HT V L F+ E ILA+GS D TV LWD Sbjct: 705 GELKGHTDTVCSLRFSRDGE-ILASGSMDNTVRLWD 739 Score = 69.8 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 25/107 (23%), Positives = 40/107 (37%), Gaps = 13/107 (12%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H+G ++ + P N +AT VL++D L+GH Sbjct: 667 GHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGHGL----------MVGELKGHTDTVC 715 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTA 232 L ++ + L S S D+T+ LWD ++ D TGH Sbjct: 716 SLRFSRD-GEILASGSMDNTVRLWDAIKAFEDLET-DDFTTATGHIN 760 Score = 44.4 bits (103), Expect = 9e-05, Method: Composition-based stats. Identities = 13/96 (13%), Positives = 30/96 (31%), Gaps = 18/96 (18%) Query: 332 HNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELL-----------------FIH 374 + +++A D + V I Sbjct: 480 DDSSLIAGGFADSTVRVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKIL 539 Query: 375 GGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 410 GH+ + S++P+ +++ S SED +++W + Sbjct: 540 YGHSGPVYGASFSPDRNYLL-SSSEDGTVRLWSLQT 574 >4V6W-Ag nrPDB Length = 318 Score = 204 bits (519), Expect = 6e-53, Method: Composition-based stats. Identities = 75/309 (24%), Positives = 131/309 (42%), Gaps = 36/309 (11%) Query: 122 EIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQ 181 I H G V + P++ I + + ++V+ T+ E + P RL GH Sbjct: 9 GTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRD----EDTNYGYPQKRLYGHS 64 Query: 182 KEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHL 241 + + + Y LS S D T+ LWD+ A R F GHT V VA+ Sbjct: 65 HFISDVVLSSD-GNYALSGSWDQTLRLWDLAAGKTTRR-------FEGHTKDVLSVAFSA 116 Query: 242 LHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP-YSEFILATGSADK 300 + S + D+ + +W+T K + D HT V+C+ F+P +S I+ + D+ Sbjct: 117 DNRQ-IVSGSRDKTIKLWNTLAEC--KFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDR 173 Query: 301 TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 360 TV +W+L N KLK ++ H + V SP ++ S G D + +WDL+ + Sbjct: 174 TVKVWNLANCKLK-NNHHGHNGYLNTVTVSPDG-SLCTSGGKDSKALLWDLNDGKNLYTL 231 Query: 361 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMA-ENVYNDEEPE 419 E H I+ ++PN W+ + +++W +A + + PE Sbjct: 232 E---------------HNDIINALCFSPNRYWLCVAYG--PSIKIWDLACKKTVEELRPE 274 Query: 420 IPASELETN 428 + + + + Sbjct: 275 VVSPTSKAD 283 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 62/256 (24%), Positives = 111/256 (43%), Gaps = 24/256 (9%) Query: 168 SGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIF 227 S Q L GH ++ NP ++SAS D T+ +W + + K ++ Sbjct: 2 SETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLY 61 Query: 228 TGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP 287 GH+ + DV S + DQ L +WD K + + HT +V ++F+ Sbjct: 62 -GHSHFISDVVLSSDGNYAL-SGSWDQTLRLWDL---AAGKTTRRFEGHTKDVLSVAFSA 116 Query: 288 YSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET-ILASSGTDRRL 346 + I+ +GS DKT+ LW+ + H D + V++SP++ I+ S G DR + Sbjct: 117 DNRQIV-SGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTV 175 Query: 347 HVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 VW+L+ +L H GH ++ + +P+ + S +D+ +W Sbjct: 176 KVWNLANC--------------KLKNNHHGHNGYLNTVTVSPDGS-LCTSGGKDSKALLW 220 Query: 407 QM--AENVYNDEEPEI 420 + +N+Y E +I Sbjct: 221 DLNDGKNLYTLEHNDI 236 >6HQA-B nrPDB Length = 722 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 65/294 (22%), Positives = 127/294 (43%), Gaps = 41/294 (13%) Query: 130 EVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKP----EPSGECQPD-------LRLR 178 ++ ++ ++ ++A+ S + ++ P + +P + D RL Sbjct: 392 DLTCLKFND-DSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLV 450 Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 GH YG+ ++P+ N YL+S S+D T+ LW ++ + GH++ V DV Sbjct: 451 GHSGAVYGVDFSPD-NRYLISCSEDKTVRLWSLDT-------YTCLVSYKGHSSSVWDVK 502 Query: 239 WHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSA 298 + + F + + DQ +W + + P H +V+C+ F+P S ++ TGS+ Sbjct: 503 FSPMG-HYFATASHDQTARLW---SCDHIYPLRIFAGHLNDVDCVEFHPNSTYLF-TGSS 557 Query: 299 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQ 358 DKT +WD+ + + F H I + SP LAS+G D + +WD+S + Sbjct: 558 DKTARMWDIARGEC-VRVFMGHSGAINCLAVSPDGRW-LASAGEDSVVCLWDISTGRRIK 615 Query: 359 STEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENV 412 + + I +++ ++ S DN ++VW + +N Sbjct: 616 AMRGHG-------------RSSIYSLAFSREGT-VLVSTGADNSVRVWDVKKNT 655 Score = 164 bits (414), Expect = 7e-41, Method: Composition-based stats. Identities = 55/239 (23%), Positives = 99/239 (41%), Gaps = 27/239 (11%) Query: 124 KINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKE 183 + H G V + P N +I + + V ++ + + +GH Sbjct: 449 LVGHSGAVYGVDFSPDNRYLI-SCSEDKTVRLWSLDTYTCL----------VSYKGHSSS 497 Query: 184 GYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLH 243 + + ++P + Y +AS D T LW + I IF GH V+ V +H Sbjct: 498 VWDVKFSP-MGHYFATASHDQTARLWSCDH-------IYPLRIFAGHLNDVDCVEFHPNS 549 Query: 244 ESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVA 303 LF + + D+ +WD + H+ +NCL+ +P + LA+ D V Sbjct: 550 TYLF-TGSSDKTARMWDI---ARGECVRVFMGHSGAINCLAVSPDGRW-LASAGEDSVVC 604 Query: 304 LWDLRNLKLKLHSFESH-KDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTE 361 LWD+ + ++ + H + I+ + +S T+L S+G D + VWD+ K S + Sbjct: 605 LWDISTGR-RIKAMRGHGRSSIYSLAFS-REGTVLVSTGADNSVRVWDVKKNTNSPSAQ 661 Score = 86.0 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 30/185 (16%), Positives = 62/185 (33%), Gaps = 41/185 (22%) Query: 269 PSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL-----------------RNLK 311 +T ++ CL FN ++A+G D + LW + N Sbjct: 382 CMYTFHNTNNDLTCLKFN-DDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDG 440 Query: 312 LKL---HSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPP 368 + + H ++ V +SP N ++ S D+ + +W L Sbjct: 441 VAVKGSRRLVGHSGAVYGVDFSPDNRYLI-SCSEDKTVRLWSLDTYT------------- 486 Query: 369 ELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE----NVYNDEEPEIPASE 424 L + GH++ + D ++P + S D ++W ++ ++ E Sbjct: 487 -CLVSYKGHSSSVWDVKFSPMG-HYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVE 544 Query: 425 LETNT 429 N+ Sbjct: 545 FHPNS 549 >3DM0-A nrPDB Length = 694 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 68/307 (22%), Positives = 130/307 (42%), Gaps = 35/307 (11%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H V NA +I + + ++++ TK + RL GH Sbjct: 380 AHTDMVTAIATPIDNADIIVSASRDKSIILWKLTK-----DDKAYGVAQRRLTGHSHFVE 434 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 + + + + LS S D + LWD+ A R F GHT V VA+ L + Sbjct: 435 DVVLSSD-GQFALSGSWDGELRLWDLAAGVSTRR-------FVGHTKDVLSVAFSLDNRQ 486 Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS-EFILATGSADKTVAL 304 S + D+ + +W+T S + H V+C+ F+P + + + + S DKTV + Sbjct: 487 -IVSASRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKV 545 Query: 305 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAE 364 W+L N KL+ + H + V SP ++ AS G D + +WDL++ + S E Sbjct: 546 WNLSNCKLR-STLAGHTGYVSTVAVSPDG-SLCASGGKDGVVLLWDLAEGKKLYSLEA-- 601 Query: 365 DGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM-AENVYNDEEPEIPAS 423 + I ++PN W+ + ++ +++W + ++++ D + ++ A Sbjct: 602 -------------NSVIHALCFSPNRYWLCAAT--EHGIKIWDLESKSIVEDLKVDLKAE 646 Query: 424 ELETNTA 430 + + + Sbjct: 647 AEKADNS 653 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 46/272 (16%), Positives = 97/272 (35%), Gaps = 67/272 (24%) Query: 189 WNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFG 248 W + +AS T+ A + K HT +V +A + + + Sbjct: 340 WYAVRTAVINAASGRQTVDAALAAAQTNAAAGLVLKGTMRAHTDMVTAIATPIDNADIIV 399 Query: 249 SVADDQKLMIWDTRNNN------------------------------------------- 265 S + D+ +++W ++ Sbjct: 400 SASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQFALSGSWDGELRLWDL 459 Query: 266 -TSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF----ESH 320 + HT +V ++F+ + I+ + S D+T+ LW+ L ++ E H Sbjct: 460 AAGVSTRRFVGHTKDVLSVAFSLDNRQIV-SASRDRTIKLWN--TLGECKYTISEGGEGH 516 Query: 321 KDEIFQVQWSPHN-ETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTA 379 +D + V++SP+ + + S+ D+ + VW+LS + GHT Sbjct: 517 RDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLRSTL--------------AGHTG 562 Query: 380 KISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 +S + +P+ + S +D ++ +W +AE Sbjct: 563 YVSTVAVSPDGS-LCASGGKDGVVLLWDLAEG 593 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 45/246 (18%), Positives = 94/246 (38%), Gaps = 46/246 (18%) Query: 125 INHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRL--RGHQK 182 + H +V + N ++ + + + +++ GEC+ + GH+ Sbjct: 469 VGHTKDVLSVAFSLDNRQIV-SASRDRTIKLWNTL---------GECKYTISEGGEGHRD 518 Query: 183 EGYGLSWNPNL-NGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHL 241 + ++PN ++SAS D T+ +W+++ ++ GHT V VA Sbjct: 519 WVSCVRFSPNTLQPTIVSASWDKTVKVWNLSN-------CKLRSTLAGHTGYVSTVAVSP 571 Query: 242 LHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKT 301 SL S D +++WD K ++++A++ ++ L F+P + + L + Sbjct: 572 DG-SLCASGGKDGVVLLWDLAE---GKKLYSLEANS-VIHALCFSP-NRYWLCAATEHG- 624 Query: 302 VALWDLRNLKL---------KLHSFESHKDEI---------FQVQWSPHNETILASSGTD 343 + +WDL + + + + WS T+ S TD Sbjct: 625 IKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLF-SGYTD 683 Query: 344 RRLHVW 349 + VW Sbjct: 684 GVIRVW 689 >6F3T-A nrPDB Length = 608 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 71/252 (28%), Positives = 112/252 (44%), Gaps = 30/252 (11%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 L GH YG S++P+ N YLLS+S+D T+ LW + + GH V D Sbjct: 347 LYGHSGPVYGASFSPDRN-YLLSSSEDGTVRLWSLQT-------FTCLVGYKGHNYPVWD 398 Query: 237 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATG 296 + F S D+ +W T + +P H A+VNC F+P + +ATG Sbjct: 399 TQFSPYG-YYFVSGGHDRVARLWAT---DHYQPLRIFAGHLADVNCTRFHP-NSNYVATG 453 Query: 297 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGE 356 SAD+TV LWD+ N + F HK I + +SP+ LA+ TD R+ +WD+ Sbjct: 454 SADRTVRLWDVLNGNC-VRIFTGHKGPIHSLTFSPNGR-FLATGATDGRVLLWDI----- 506 Query: 357 EQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDE 416 G ++ GHT + ++ + I+ S S DN +++W + + E Sbjct: 507 ---------GHGLMVGELKGHTDTVCSLRFSRDGE-ILASGSMDNTVRLWDAIKAFEDLE 556 Query: 417 EPEIPASELETN 428 + + N Sbjct: 557 TDDFTTATGHIN 568 Score = 131 bits (328), Expect = 7e-31, Method: Composition-based stats. Identities = 48/219 (21%), Positives = 77/219 (35%), Gaps = 46/219 (21%) Query: 120 EIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPS---------------- 163 E++I H G V A + P + + + + V ++ Sbjct: 343 ELKILYGHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQF 401 Query: 164 ----------------KPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTIC 207 + + QP GH + ++PN N Y+ + S D T+ Sbjct: 402 SPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN-YVATGSADRTVR 460 Query: 208 LWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTS 267 LWD+ IFTGH + + + + A D ++++WD Sbjct: 461 LWDVLNGN-------CVRIFTGHKGPIHSLTFSPNGR-FLATGATDGRVLLWDI---GHG 509 Query: 268 KPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 + HT V L F+ E ILA+GS D TV LWD Sbjct: 510 LMVGELKGHTDTVCSLRFSRDGE-ILASGSMDNTVRLWD 547 Score = 76.0 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 28/199 (14%), Positives = 54/199 (27%), Gaps = 46/199 (23%) Query: 241 LLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADK 300 SL D + +W ++ + I S D Sbjct: 287 TDDSSLIAGGFADSTVRVWSVT--------------PKKLRSVKQASDLSLIDKE-SDDV 331 Query: 301 TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 360 + D + +L H ++ +SP + L SS D + +W L Sbjct: 332 LERIMDEKTAS-ELKILYGHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFTCLVGY 389 Query: 361 EDAEDGPPELLF----------------------------IHGGHTAKISDFSWNPNEPW 392 + + F I GH A ++ ++PN Sbjct: 390 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPN-SN 448 Query: 393 IICSVSEDNIMQVWQMAEN 411 + + S D +++W + Sbjct: 449 YVATGSADRTVRLWDVLNG 467 Score = 68.3 bits (165), Expect = 6e-12, Method: Composition-based stats. Identities = 25/107 (23%), Positives = 40/107 (37%), Gaps = 13/107 (12%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H+G ++ + P N +AT VL++D L+GH Sbjct: 475 GHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGHGL----------MVGELKGHTDTVC 523 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTA 232 L ++ + L S S D+T+ LWD ++ D TGH Sbjct: 524 SLRFSRD-GEILASGSMDNTVRLWDAIKAFEDLET-DDFTTATGHIN 568 >5M25-A nrPDB Length = 434 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 67/336 (19%), Positives = 136/336 (40%), Gaps = 44/336 (13%) Query: 83 LLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIE-------IKINHEGEVNRAR 135 + I + Q P + D + + + GG + ++ H V+ + Sbjct: 93 IRIQADQTPEDLDMEDNDIIEAHREQIGGSATQSKPTPVKPNYALKFTLAGHTKAVSSVK 152 Query: 136 YMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNG 195 + P +A+ + + ++ + + + + + GH+ ++W+ + N Sbjct: 153 FSPNGEW-LASSSADKLIKIWG----------AYDGKFEKTISGHKLGISDVAWSSDSN- 200 Query: 196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 255 L+SASDD T+ +WD+++ GH+ V ++ +L S + D+ Sbjct: 201 LLVSASDDKTLKIWDVSSG-------KCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDES 252 Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 315 + IWD + T K T+ AH+ V+ + FN I+++ S D +WD + + Sbjct: 253 VRIWDVK---TGKCLKTLPAHSDPVSAVHFNRDGSLIVSS-SYDGLCRIWDTASGQCLKT 308 Query: 316 SFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHG 375 + + V++SP+ + ILA + D L +WD SK G+ T +F + Sbjct: 309 LIDDDNPPVSFVKFSPNGKYILA-ATLDNTLKLWDYSK-GKCLKTYTGHKNEKYCIFAN- 365 Query: 376 GHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 ++ I S SEDN++ +W + Sbjct: 366 ----------FSVTGGKWIVSGSEDNLVYIWNLQTK 391 >6QX9-5O nrPDB Length = 357 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 68/301 (22%), Positives = 118/301 (39%), Gaps = 34/301 (11%) Query: 113 GSVCGKIEIEIKI--NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGE 170 C ++ I + HEGEV ++ P N +A+ +L+++ G+ Sbjct: 49 PPRCSSLQAPIMLLSGHEGEVYCCKFHP-NGSTLASAGFDRLILLWNVY---------GD 98 Query: 171 CQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGH 230 C L+GH L +N + L SAS D T+ +WD + R GH Sbjct: 99 CDNYATLKGHSGAVMELHYNTD-GSMLFSASTDKTVAVWDSETGERVKR-------LKGH 150 Query: 231 TAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSE 290 T+ V L + +DD + +WD R + +T +V ++FN S+ Sbjct: 151 TSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ----NTYQVLAVTFNDTSD 206 Query: 291 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWD 350 I+ +G D + +WDLR KL ++ H D + + S +L+++ D + VWD Sbjct: 207 QII-SGGIDNDIKVWDLRQNKL-TYTMRGHADSVTGLSLSSEGSYLLSNA-MDNTVRVWD 263 Query: 351 LSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 410 + ++ G + SW+P+ I + S D + VW Sbjct: 264 VRPFAPKERCVKIFQGNVHNF------EKNLLRCSWSPDGSK-IAAGSADRFVYVWDTTS 316 Query: 411 N 411 Sbjct: 317 R 317 >2H9P-A nrPDB Length = 329 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 61/286 (21%), Positives = 121/286 (42%), Gaps = 37/286 (12%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H V+ ++ P +A+ + + ++ + + + + + GH+ Sbjct: 38 GHTKAVSSVKFSPNGEW-LASSSADKLIKIWG----------AYDGKFEKTISGHKLGIS 86 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 ++W+ + N L+SASDD T+ +WD+++ GH+ V ++ + Sbjct: 87 DVAWSSDSN-LLVSASDDKTLKIWDVSSG-------KCLKTLKGHSNYVFCCNFNP-QSN 137 Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 305 L S + D+ + IWD + T K T+ AH+ V+ + FN I+++ S D +W Sbjct: 138 LIVSGSFDESVRIWDVK---TGKCLKTLPAHSDPVSAVHFNRDGSLIVSS-SYDGLCRIW 193 Query: 306 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED 365 D + + + + V++SP+ + ILA + D L +WD SK G+ T Sbjct: 194 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILA-ATLDNTLKLWDYSK-GKCLKTYTGHK 251 Query: 366 GPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 +F + ++ I S SEDN++ +W + Sbjct: 252 NEKYCIFAN-----------FSVTGGKWIVSGSEDNLVYIWNLQTK 286 Score = 174 bits (440), Expect = 9e-44, Method: Composition-based stats. Identities = 62/265 (23%), Positives = 119/265 (44%), Gaps = 31/265 (11%) Query: 147 KTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTI 206 + ++ P+ +P+ + L GH K + ++PN +L S+S D I Sbjct: 8 SSGRENLYFQGTQSKPTPVKPNYALKF--TLAGHTKAVSSVKFSPN-GEWLASSSADKLI 64 Query: 207 CLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNT 266 +W E +GH + DVAW +L S +DD+ L IWD ++ Sbjct: 65 KIWGAYDGKFE-------KTISGHKLGISDVAWSS-DSNLLVSASDDKTLKIWDV---SS 113 Query: 267 SKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQ 326 K T+ H+ V C +FNP ++ +GS D++V +WD++ K L + +H D + Sbjct: 114 GKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWDVKTGKC-LKTLPAHSDPVSA 171 Query: 327 VQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSW 386 V ++ + +++ SS D +WD + ++ D ++ P +S + Sbjct: 172 VHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP-------------VSFVKF 217 Query: 387 NPNEPWIICSVSEDNIMQVWQMAEN 411 +PN +I+ + DN +++W ++ Sbjct: 218 SPNGKYILAAT-LDNTLKLWDYSKG 241 >6G51-g nrPDB Length = 317 Score = 190 bits (483), Expect = 7e-49, Method: Composition-based stats. Identities = 66/292 (22%), Positives = 121/292 (41%), Gaps = 36/292 (12%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H G V + PQ +I + + ++++ T+ + + P LRGH Sbjct: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR-----DETNYGIPQRALRGHSHFVS 67 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 + + + + LS S D T+ LWD+ R F GHT V VA+ + Sbjct: 68 DVVISSD-GQFALSGSWDGTLRLWDLTTGTTTRR-------FVGHTKDVLSVAFSSDNRQ 119 Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEF-ILATGSADKTVAL 304 S + D+ + +W+T ++H+ V+C+ F+P S I+ + DK V + Sbjct: 120 -IVSGSRDKTIKLWNTLGVCKYTVQD--ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 Query: 305 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAE 364 W+L N KLK + H + V SP ++ AS G D + +WDL++ + + + Sbjct: 177 WNLANCKLKTNHI-GHTGYLNTVTVSPDG-SLCASGGKDGQAMLWDLNEGKHLYTLDGGD 234 Query: 365 DGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDE 416 I+ ++PN W+ + +++W + + DE Sbjct: 235 ---------------IINALCFSPNRYWLCAATG--PSIKIWDLEGKIIVDE 269 Score = 184 bits (467), Expect = 6e-47, Method: Composition-based stats. Identities = 58/245 (23%), Positives = 105/245 (42%), Gaps = 23/245 (9%) Query: 168 SGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIF 227 + + L+GH ++ P +LSAS D TI +W + + + + Sbjct: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGI--PQRAL 59 Query: 228 TGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP 287 GH+ V DV + S + D L +WD T + HT +V ++F+ Sbjct: 60 RGHSHFVSDVVISSDGQFAL-SGSWDGTLRLWDL---TTGTTTRRFVGHTKDVLSVAFSS 115 Query: 288 YSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET-ILASSGTDRRL 346 + I+ +GS DKT+ LW+ + ESH + + V++SP++ I+ S G D+ + Sbjct: 116 DNRQIV-SGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 Query: 347 HVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 VW+L+ +L H GHT ++ + +P+ + S +D +W Sbjct: 175 KVWNLANC--------------KLKTNHIGHTGYLNTVTVSPDGS-LCASGGKDGQAMLW 219 Query: 407 QMAEN 411 + E Sbjct: 220 DLNEG 224 >5MZH-A nrPDB Length = 452 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 64/292 (21%), Positives = 113/292 (38%), Gaps = 40/292 (13%) Query: 120 EIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRG 179 E+ H+ V + I T + ++D + Q L+G Sbjct: 128 EVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWD----------AYTGQLYYTLKG 177 Query: 180 HQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW 239 HQ E LS+NP + + + S D+T LWD+ + + GH A + + + Sbjct: 178 HQTEIVCLSFNPQ-STIIATGSMDNTAKLWDVETGQE-------RATLAGHRAEIVSLGF 229 Query: 240 HLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSAD 299 + L + + D +WD R T + H + H EV+ FN Y+ ++ +GS D Sbjct: 230 NT-GGDLIVTGSFDHDSRLWDVR---TGQCVHVLSGHRGEVSSTQFN-YAGTLVVSGSID 284 Query: 300 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQS 359 T LWD+R+ + L + H DE+ V + T + S+ D ++ + + Sbjct: 285 CTSRLWDVRSGRC-LSVKQGHTDEVLDVAFDAAG-TKMVSASADGSARLYHTLTGVCQHT 342 Query: 360 TEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 GH +IS ++NP +I + S D ++W Sbjct: 343 LV--------------GHEGEISKVAFNPQGTRLI-TASSDKTCRLWDCDTG 379 Score = 188 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 68/308 (22%), Positives = 118/308 (38%), Gaps = 70/308 (22%) Query: 144 IATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDD 203 IA P D +V K + Q L+GHQ E LS+NP + + + S D Sbjct: 142 IAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQ-STIIATGSMD 200 Query: 204 HTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRN 263 +T LWD+ + + GH A + + ++ L + + D +WD R Sbjct: 201 NTAKLWDVETGQE-------RATLAGHRAEIVSLGFNT-GGDLIVTGSFDHDSRLWDVR- 251 Query: 264 NNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL----------- 312 T + H + H EV+ FN Y+ ++ +GS D T LWD+R+ + Sbjct: 252 --TGQCVHVLSGHRGEVSSTQFN-YAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEV 308 Query: 313 ------------------------------KLHSFESHKDEIFQVQWSPHNETILASSGT 342 H+ H+ EI +V ++P ++ ++ + Sbjct: 309 LDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLI-TASS 367 Query: 343 DRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNI 402 D+ +WD E L + GHT +I ++N +II + S+DN Sbjct: 368 DKTCRLWDCDTG--------------ECLQVLEGHTDEIFSCAFNYEGDFII-TGSKDNT 412 Query: 403 MQVWQMAE 410 ++W+ Sbjct: 413 CRIWKALT 420 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 39/188 (20%), Positives = 75/188 (39%), Gaps = 24/188 (12%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H GEV+ ++ ++ + + ++D SG C + GH E Sbjct: 261 GHRGEVSSTQFN-YAGTLVVSGSIDCTSRLWDVR--------SGRCLSVKQ--GHTDEVL 309 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 ++++ ++SAS D + L+ +H GH + VA++ Sbjct: 310 DVAFD-AAGTKMVSASADGSARLYHTLTGVCQH-------TLVGHEGEISKVAFNPQGTR 361 Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 305 L + + D+ +WD +T + ++ HT E+ +FN +FI+ TGS D T +W Sbjct: 362 LI-TASSDKTCRLWDC---DTGECLQVLEGHTDEIFSCAFNYEGDFII-TGSKDNTCRIW 416 Query: 306 DLRNLKLK 313 + Sbjct: 417 KALTASSQ 424 Score = 62.1 bits (149), Expect = 5e-10, Method: Composition-based stats. Identities = 21/95 (22%), Positives = 41/95 (43%), Gaps = 12/95 (12%) Query: 123 IKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQK 182 + HEGE+++ + PQ +I T + ++D +GEC L GH Sbjct: 342 TLVGHEGEISKVAFNPQGTRLI-TASSDKTCRLWDC--------DTGEC--LQVLEGHTD 390 Query: 183 EGYGLSWNPNLNGYLLSASDDHTICLWDINATPKE 217 E + ++N ++++ S D+T +W + Sbjct: 391 EIFSCAFN-YEGDFIITGSKDNTCRIWKALTASSQ 424 >6ID0-T nrPDB Length = 514 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 62/314 (19%), Positives = 114/314 (36%), Gaps = 44/314 (14%) Query: 125 INHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEG 184 H G +R + N+ V+ T + L+ KP+ + + GH Sbjct: 148 YRHPGASDRPQPTAMNSIVMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWV 207 Query: 185 YGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHE 244 ++ P N + ++ S D TI +WD+ + K TGH + V V Sbjct: 208 RCIAVEP-GNQWFVTGSADRTIKIWDLASG-------KLKLSLTGHISTVRGVIVSTRSP 259 Query: 245 SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 304 LF S +D+++ WD N + H H + V L +P + +L T S D T + Sbjct: 260 YLF-SCGEDKQVKCWDLEYNKVIRHYH---GHLSAVYGLDLHPTID-VLVTCSRDSTARI 314 Query: 305 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAE 364 WD+R K +H+ H + + V+ I+ + D + +WDL + + + Sbjct: 315 WDVRT-KASVHTLSGHTNAVATVRCQAAEPQII-TGSHDTTIRLWDLVAGKTRVTLTNHK 372 Query: 365 DGPPELLF---------------------------IHGGHTAKISDFSWNPNEPWIICSV 397 ++ GH A I+ + N + ++ S Sbjct: 373 KSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDG--VLVSG 430 Query: 398 SEDNIMQVWQMAEN 411 +++ M +W Sbjct: 431 ADNGTMHLWDWRTG 444 Score = 73.3 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 34/196 (17%), Positives = 67/196 (34%), Gaps = 28/196 (14%) Query: 115 VCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPD 174 V K + H V R +I T + + + ++D ++ Sbjct: 317 VRTKASVHTLSGHTNAVATVRCQAAEPQII-TGSHDTTIRLWDLVAGKTR---------- 365 Query: 175 LRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVV 234 + L H+K + +P + S S D+ I W +GH A++ Sbjct: 366 VTLTNHKKSVRAVVLHP-RHYTFASGSPDN-IKQWKFPDG-------SFIQNLSGHNAII 416 Query: 235 EDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDA-----HTAEVNCLSFNPYS 289 + + + S AD+ + +WD R + H + + +F+ Sbjct: 417 NTLTVNSDG--VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSE 474 Query: 290 EFILATGSADKTVALW 305 +L T ADKT+ ++ Sbjct: 475 SRLL-TAEADKTIKVY 489 >5NNZ-B nrPDB Length = 415 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 71/329 (21%), Positives = 126/329 (38%), Gaps = 44/329 (13%) Query: 83 LLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNAC 142 L + +V L + F YD E+ H V + Sbjct: 93 LPLTNVALNKSGSCFITGSYDRT----CKLWDTASGEELNTLEGHRNVVYAIAFNNPYGD 148 Query: 143 VIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASD 202 IAT + ++ +G+C RGH E LS+NP + + + S Sbjct: 149 KIATGSFDKTCKLWSV--------ETGKCYH--TFRGHTAEIVCLSFNPQ-STLVATGSM 197 Query: 203 DHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTR 262 D T LWDI + + GH+A + ++++ + + + + D +++WD Sbjct: 198 DTTAKLWDIQNGEEVY-------TLRGHSAEIISLSFNTSGDRII-TGSFDHTVVVWD-- 247 Query: 263 NNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKD 322 +T + + + H AE++ SFN IL TGS DKT LWD N K + + H D Sbjct: 248 -ADTGRKVNILIGHCAEISSASFNWDCSLIL-TGSMDKTCKLWDATNGKC-VATLTGHDD 304 Query: 323 EIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKIS 382 EI + + ++A++ D ++ + + + GH +IS Sbjct: 305 EILDSCFDYTGK-LIATASADGTARIFSAAT--------------RKCIAKLEGHEGEIS 349 Query: 383 DFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 S+NP ++ + S D ++W Sbjct: 350 KISFNPQGNHLL-TGSSDKTARIWDAQTG 377 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 60/263 (22%), Positives = 100/263 (38%), Gaps = 62/263 (23%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H E+ + PQ + ++AT + + ++D + LRGH E Sbjct: 175 GHTAEIVCLSFNPQ-STLVATGSMDTTAKLWDI----------QNGEEVYTLRGHSAEII 223 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 LS+N +++ S DHT+ +WD + K NI GH A + +++ S Sbjct: 224 SLSFNT-SGDRIITGSFDHTVVVWDADTGRK-------VNILIGHCAEISSASFN-WDCS 274 Query: 246 LFGSVADDQKLMIWDTRNNN---------------------------------------T 266 L + + D+ +WD N T Sbjct: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAAT 334 Query: 267 SKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQ 326 K ++ H E++ +SFNP +L TGS+DKT +WD + + L E H DEIF Sbjct: 335 RKCIAKLEGHEGEISKISFNPQGNHLL-TGSSDKTARIWDAQTGQC-LQVLEGHTDEIFS 392 Query: 327 VQWSPHNETILASSGTDRRLHVW 349 ++ I+ + D +W Sbjct: 393 CAFNYKG-NIVITGSKDNTCRIW 414 >4V8M-A7 nrPDB Length = 318 Score = 178 bits (451), Expect = 5e-45, Method: Composition-based stats. Identities = 69/292 (23%), Positives = 123/292 (42%), Gaps = 38/292 (13%) Query: 122 EIKINHEGEVNRARY--MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRG 179 H G V P+ A + + + +L + E S PD RL G Sbjct: 7 GQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGL-PDRRLEG 65 Query: 180 HQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW 239 H ++ + N + +SAS DH++ LW++ +++ F GHT V VA+ Sbjct: 66 HSAFVSDVALS-NNGNFAVSASWDHSLRLWNLQNGQCQYK-------FLGHTKDVLSVAF 117 Query: 240 HLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVD--AHTAEVNCLSFNPYSE-FILATG 296 + S D L +W+ + + HT+ AHT V+C+ F+P + ++ +G Sbjct: 118 SPDNRQ-IVSGGRDNALRVWNVK----GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSG 172 Query: 297 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGE 356 D V +WDL +L + + H + + V SP ++ ASS D +WDL+K Sbjct: 173 GWDNLVKVWDLATGRL-VTDLKGHTNYVTSVTVSPDG-SLCASSDKDGVARLWDLTKG-- 228 Query: 357 EQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 E +E A P I+ ++PN W+ + + ++++ + Sbjct: 229 EALSEMAAGAP-------------INQICFSPNRYWMCAAT--EKGIRIFDL 265 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 53/241 (21%), Positives = 105/241 (43%), Gaps = 25/241 (10%) Query: 176 RLRGHQKEGYGLSW--NPNLNGYLLSASDDHTICLW--DINATPKEHRVIDAKNIFTGHT 231 +L GH+ L+ P ++S S D T+ W + + E GH+ Sbjct: 8 QLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHS 67 Query: 232 AVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEF 291 A V DVA + + S + D L +W+ +N + + HT +V ++F+P + Sbjct: 68 AFVSDVALS-NNGNFAVSASWDHSLRLWNLQN---GQCQYKFLGHTKDVLSVAFSPDNRQ 123 Query: 292 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPH-NETILASSGTDRRLHVWD 350 I+ +G D + +W+++ + S +H D + V++SP + ++ S G D + VWD Sbjct: 124 IV-SGGRDNALRVWNVKGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWD 182 Query: 351 LSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 410 L+ L+ GHT ++ + +P+ + S +D + ++W + + Sbjct: 183 LATG--------------RLVTDLKGHTNYVTSVTVSPDGS-LCASSDKDGVARLWDLTK 227 Query: 411 N 411 Sbjct: 228 G 228 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 51/289 (17%), Positives = 112/289 (38%), Gaps = 39/289 (13%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H V+ + N + + + +++ +G+CQ + GH K+ Sbjct: 65 GHSAFVSDVA-LSNNGNFAVSASWDHSLRLWNLQ--------NGQCQ--YKFLGHTKDVL 113 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFT--GHTAVVEDVAWHL-L 242 ++++P+ N ++S D+ + +W++ + + + HT V V + L Sbjct: 114 SVAFSPD-NRQIVSGGRDNALRVWNVKG--------ECMHTLSRGAHTDWVSCVRFSPSL 164 Query: 243 HESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTV 302 + S D + +WD T + + HT V ++ +P + A+ D Sbjct: 165 DAPVIVSGGWDNLVKVWDL---ATGRLVTDLKGHTNYVTSVTVSPDGS-LCASSDKDGVA 220 Query: 303 ALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTED 362 LWDL + I Q+ +SP+ + A T++ + ++DL Sbjct: 221 RLWDLTKGEALSEMAAG--APINQICFSPNRYWMCA--ATEKGIRIFDLENKDIIVELAP 276 Query: 363 AEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 G +++ + +W+ + + S DN+++VW ++EN Sbjct: 277 EHQGSKKIV-------PECVSIAWSADGSTLY-SGYTDNVIRVWGVSEN 317 >5OPT-p nrPDB Length = 318 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 70/308 (22%), Positives = 129/308 (41%), Gaps = 39/308 (12%) Query: 126 NHEGEVNRARY--MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKE 183 H G V + + + + + ++ + E P+ RL GH Sbjct: 11 GHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNM-DRNSEECEYGFPERRLEGHSAF 69 Query: 184 GYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLH 243 ++ + N + +SAS DH++ LW++ +H+ F GHT V V + + Sbjct: 70 VSDVALS-NNGDFAVSASWDHSLRLWNLQTGVCQHK-------FLGHTKDVLSVTFSPDN 121 Query: 244 ESLFGSVADDQKLMIWDTRNNNTSKPSHTV--DAHTAEVNCLSFNPYSE-FILATGSADK 300 S D L +W+ + + HT+ AHT V+C+ F+P E ++ +G D Sbjct: 122 RQ-IVSGGRDNALRVWNVK----GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDN 176 Query: 301 TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 360 V +WD+ + +L L + H + I V SP ++ ASS D +WDL+K E + Sbjct: 177 LVKVWDIASGRL-LTDLKGHTNYITSVTVSPDG-SLCASSDKDGVARLWDLTKG--EALS 232 Query: 361 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM-AENVYNDEEPE 419 E A P I+ ++PN W+ + + ++++ + ++V + PE Sbjct: 233 EMAAGAP-------------INQICFSPNRYWMCAAT--EKGIRIFDLENKDVIVELAPE 277 Query: 420 IPASELET 427 +T Sbjct: 278 AQQKSKKT 285 Score = 173 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 57/241 (23%), Positives = 107/241 (44%), Gaps = 25/241 (10%) Query: 176 RLRGHQKEGYGLSWNPNLNGYL--LSASDDHTICLW--DINATPKEHRVIDAKNIFTGHT 231 +L+GH+ L+ Y+ +S S D+T+ W +++ +E + GH+ Sbjct: 8 QLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHS 67 Query: 232 AVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEF 291 A V DVA + S + D L +W+ T H HT +V ++F+P + Sbjct: 68 AFVSDVALS-NNGDFAVSASWDHSLRLWNL---QTGVCQHKFLGHTKDVLSVTFSPDNRQ 123 Query: 292 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET-ILASSGTDRRLHVWD 350 I+ +G D + +W+++ L +H D + V++SP ET ++ S G D + VWD Sbjct: 124 IV-SGGRDNALRVWNVKGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWD 182 Query: 351 LSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 410 ++ LL GHT I+ + +P+ + S +D + ++W + + Sbjct: 183 IASG--------------RLLTDLKGHTNYITSVTVSPDGS-LCASSDKDGVARLWDLTK 227 Query: 411 N 411 Sbjct: 228 G 228 Score = 111 bits (277), Expect = 6e-25, Method: Composition-based stats. Identities = 45/276 (16%), Positives = 89/276 (32%), Gaps = 72/276 (26%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H V+ + N + + + +++ +G CQ + GH K+ Sbjct: 65 GHSAFVSDVA-LSNNGDFAVSASWDHSLRLWNLQ--------TGVCQH--KFLGHTKDVL 113 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHL-LHE 244 ++++P+ N ++S D+ + +W++ H + HT V V + L Sbjct: 114 SVTFSPD-NRQIVSGGRDNALRVWNVK-GECLHTLGRGA-----HTDWVSCVRFSPSLET 166 Query: 245 SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 304 L S D + +WD + + + HT + ++ +P + A+ D L Sbjct: 167 PLIVSGGWDNLVKVWDI---ASGRLLTDLKGHTNYITSVTVSPDGS-LCASSDKDGVARL 222 Query: 305 WDLRNLKLKLHSFESHKDEIFQVQWSPH-------------------------------- 332 WDL + I Q+ +SP+ Sbjct: 223 WDLTKGEALSEMAAG--APINQICFSPNRYWMCAATEKGIRIFDLENKDVIVELAPEAQQ 280 Query: 333 ---------------NETILASSGTDRRLHVWDLSK 353 + L S TD + VW +S+ Sbjct: 281 KSKKTPECMSIAWSADGNTLYSGYTDNVIRVWSVSE 316 >3FM0-A nrPDB Length = 345 Score = 175 bits (443), Expect = 4e-44, Method: Composition-based stats. Identities = 62/281 (22%), Positives = 121/281 (43%), Gaps = 22/281 (7%) Query: 132 NRARYMPQNA--CVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW 189 +R ++ N ++A+ + ++ C+ L GHQ+ ++W Sbjct: 17 SRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWI------CKSVLS-EGHQRTVRKVAW 69 Query: 190 NPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGS 249 +P YL SAS D T C+W K + GH V+ VAW +L + Sbjct: 70 SPC-GNYLASASFDATTCIW-----KKNQDDFECVTTLEGHENEVKSVAWAPSG-NLLAT 122 Query: 250 VADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW-DLR 308 + D+ + +W+ + + +++HT +V + ++P E +LA+ S D TV L+ + Sbjct: 123 CSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQE-LLASASYDDTVKLYREEE 181 Query: 309 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGP- 367 + + + E H+ ++ + + P + LAS DR + +W G EQ + P Sbjct: 182 DDWVCCATLEGHESTVWSLAFDPSGQR-LASCSDDRTVRIWRQYLPGNEQGVACSGSDPS 240 Query: 368 -PELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 + + G H+ I D +W + + D+ ++V+Q Sbjct: 241 WKCICTLSGFHSRTIYDIAWC-QLTGALATACGDDAIRVFQ 280 Score = 117 bits (293), Expect = 9e-27, Method: Composition-based stats. Identities = 52/250 (20%), Positives = 96/250 (38%), Gaps = 37/250 (14%) Query: 121 IEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGH 180 + HE EV + P ++AT + V V++ + E EC L H Sbjct: 98 VTTLEGHENEVKSVAWAPS-GNLLATCSRDKSVWVWEVDE-----EDEYECVSV--LNSH 149 Query: 181 QKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH 240 ++ + W+P+ L SAS D T+ L+ +E GH + V +A+ Sbjct: 150 TQDVKHVVWHPSQE-LLASASYDDTVKLY-----REEEDDWVCCATLEGHESTVWSLAFD 203 Query: 241 LLHESLFGSVADDQKLMIWD------------TRNNNTSKPSHTVDA-HTAEVNCLSFNP 287 + L S +DD+ + IW + ++ + K T+ H+ + +++ Sbjct: 204 PSGQRL-ASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQ 262 Query: 288 YSEFILATGSADKTVALWDL--------RNLKLKLHSFESHKDEIFQVQWSPHNETILAS 339 + LAT D + ++ L H ++H ++ V W+P +LAS Sbjct: 263 LTG-ALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLAS 321 Query: 340 SGTDRRLHVW 349 D + W Sbjct: 322 CSDDGEVAFW 331 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 41/194 (21%), Positives = 79/194 (40%), Gaps = 35/194 (18%) Query: 237 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATG 296 +AW+ L S D+++ IW T ++ S + H V ++++P + LA+ Sbjct: 22 LAWNPAGT-LLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNY-LASA 79 Query: 297 SADKTVALWDLRNLKL-KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIG 355 S D T +W + + E H++E+ V W+P +LA+ D+ + VW++ Sbjct: 80 SFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSG-NLLATCSRDKSVWVWEVD--- 135 Query: 356 EEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEP--------------------WIIC 395 E+ E + + HT + W+P++ W+ C Sbjct: 136 --------EEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCC 187 Query: 396 SVSEDNIMQVWQMA 409 + E + VW +A Sbjct: 188 ATLEGHESTVWSLA 201 Score = 102 bits (254), Expect = 3e-22, Method: Composition-based stats. Identities = 46/197 (23%), Positives = 81/197 (41%), Gaps = 26/197 (13%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 +H +V + P ++A+ + V ++ E + L GH+ + Sbjct: 148 SHTQDVKHVVWHPS-QELLASASYDDTVKLYR--------EEEDDWVCCATLEGHESTVW 198 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRV--------IDAKNIFTG-HTAVVED 236 L+++P L S SDD T+ +W E V +G H+ + D Sbjct: 199 SLAFDP-SGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYD 257 Query: 237 VAWHLLHESLFGSVADDQKLMIW------DTRNNNTSKPSHTVDAHTAEVNCLSFNPYSE 290 +AW L +L + DD + ++ D + S +H AH+ +VNC+++NP Sbjct: 258 IAWCQLTGALATACGDDA-IRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEP 316 Query: 291 FILATGSADKTVALWDL 307 +LA+ S D VA W Sbjct: 317 GLLASCSDDGEVAFWKY 333 Score = 57.9 bits (138), Expect = 8e-09, Method: Composition-based stats. Identities = 23/111 (20%), Positives = 38/111 (34%), Gaps = 2/111 (1%) Query: 102 YDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKH 161 NE+G K + H + + Q +AT + VF + Sbjct: 226 PGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWC-QLTGALATACGDDAIRVFQEDPN 284 Query: 162 PSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDIN 212 +P+ L + H ++ ++WNP G L S SDD + W Sbjct: 285 SDPQQPTFSLTAHL-HQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334 >5L9T-R nrPDB Length = 493 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 56/258 (21%), Positives = 105/258 (40%), Gaps = 29/258 (11%) Query: 104 NEKGEFGGFGSVCGKIEI-----EIKINH-EGEVNRARYMPQNACVIATKTPSSDVLVFD 157 +E+G G+ G ++I K++ EG R + NA +++ + +L D Sbjct: 238 SERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRD 297 Query: 158 YTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKE 217 P Q + RL+GH++E GL W+ + + L S +D+ + +W+ Sbjct: 298 IRTPP--------LQSERRLQGHRQEVCGLKWSTD-HQLLASGGNDNKLLVWN------- 341 Query: 218 HRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVAD--DQKLMIWDTRNNNTSKPSHTVDA 275 H + +T H A V+ +AW L S D+ + W+T T +P +D Sbjct: 342 HSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTL---TGQPLQCIDT 398 Query: 276 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET 335 + N +E + G + + +W +L ++ H + + SP E Sbjct: 399 GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLT-QVAKLTGHSYRVLYLAMSPDGEA 457 Query: 336 ILASSGTDRRLHVWDLSK 353 I+ +G D L W++ Sbjct: 458 IVTGAG-DETLRFWNVFS 474 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 56/299 (18%), Positives = 111/299 (37%), Gaps = 44/299 (14%) Query: 123 IKINHEGE-VNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQ 181 ++ EG+ V + + ++A T V ++D L GH Sbjct: 223 CDLSVEGDSVTSVGW-SERGNLVAVGTHKGFVQIWDAAAGKKLSM----------LEGHT 271 Query: 182 KEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHL 241 L+WN L S S D I DI P + ++ GH V + W Sbjct: 272 ARVGALAWNAEQ---LSSGSRDRMILQRDIRTPP-----LQSERRLQGHRQEVCGLKWST 323 Query: 242 LHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGS--AD 299 H L S +D KL++W+ +++ P H A V ++++P+ +LA+G AD Sbjct: 324 DH-QLLASGGNDNKLLVWN---HSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTAD 379 Query: 300 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGT-DRRLHVWDLSKIGEEQ 358 + + W+ + ++ + WS H ++++ G ++ VW + + Sbjct: 380 RCIRFWNTLTGQPLQCIDTG--SQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVA 437 Query: 359 STEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEE 417 GH+ ++ + +P+ I+ D ++ W + + +E Sbjct: 438 KL--------------TGHSYRVLYLAMSPDGEAIVTGAG-DETLRFWNVFSKTRSTKE 481 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 47/228 (20%), Positives = 86/228 (37%), Gaps = 33/228 (14%) Query: 187 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 246 + W+ + +LS + LW + + V V W +L Sbjct: 193 VDWS---SLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEG-----DSVTSVGWSERG-NL 243 Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 + IWD K ++ HTA V L++N L++GS D+ + D Sbjct: 244 VAVGTHKGFVQIWD---AAAGKKLSMLEGHTARVGALAWNAEQ---LSSGSRDRMILQRD 297 Query: 307 LRNLKLKL-HSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED 365 +R L+ + H+ E+ ++WS + +LAS G D +L VW+ S + Q + Sbjct: 298 IRTPPLQSERRLQGHRQEVCGLKWS-TDHQLLASGGNDNKLLVWNHSSLSPVQQYTE--- 353 Query: 366 GPPELLFIHGGHTAKISDFSWNPNEPWIICSVS--EDNIMQVWQMAEN 411 H A + +W+P++ ++ S D ++ W Sbjct: 354 -----------HLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTG 390 >6QX9-4B nrPDB Length = 522 Score = 174 bits (441), Expect = 7e-44, Method: Composition-based stats. Identities = 58/288 (20%), Positives = 109/288 (37%), Gaps = 46/288 (15%) Query: 126 NHEGEVNRARYMPQ-------NACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLR 178 H V + P+ +A+ V ++ +P + Sbjct: 271 GHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSD----------EPVADIE 320 Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 GH + W+P +L + D + LWD+ A + GH+ V D+A Sbjct: 321 GHTVRVARVMWHP-SGRFLGTTCYDRSWRLWDLEAQEE-------ILHQEGHSMGVYDIA 372 Query: 239 WHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSA 298 +H SL G+ D +WD R T + ++ H E+ ++F+P + + +ATGS Sbjct: 373 FHQDG-SLAGTGGLDAFGRVWDLR---TGRCIMFLEGHLKEIYGINFSP-NGYHIATGSG 427 Query: 299 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQ 358 D T +WDLR + +++ +H++ + V++ P + L + D +W Sbjct: 428 DNTCKVWDLRQRRC-VYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIW--------- 477 Query: 359 STEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 L GH K+ + + +I + S D ++W Sbjct: 478 -----THPGWSPLKTLAGHEGKVMGLDISSDG-QLIATCSYDRTFKLW 519 Score = 131 bits (328), Expect = 7e-31, Method: Composition-based stats. Identities = 50/240 (20%), Positives = 87/240 (36%), Gaps = 36/240 (15%) Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 G + ++PN + L +A LW + H GH V + Sbjct: 229 GDDRPISYCHFSPN-SKMLATACWSGLCKLWSVPDCNLLH-------TLRGHNTNVGAIV 280 Query: 239 WHLLHESLF-------GSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEF 291 +H S A D + +W ++ +P ++ HT V + ++P F Sbjct: 281 FHPKSTVSLDPKDVNLASCAADGSVKLWSL---DSDEPVADIEGHTVRVARVMWHPSGRF 337 Query: 292 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 L T D++ LWDL + LH E H ++ + + ++ + G D VWDL Sbjct: 338 -LGTTCYDRSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDG-SLAGTGGLDAFGRVWDL 394 Query: 352 SKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 + GH +I +++PN I + S DN +VW + + Sbjct: 395 RTG--------------RCIMFLEGHLKEIYGINFSPNGYH-IATGSGDNTCKVWDLRQR 439 >5FL8-q nrPDB Length = 515 Score = 174 bits (440), Expect = 8e-44, Method: Composition-based stats. Identities = 60/319 (18%), Positives = 119/319 (37%), Gaps = 70/319 (21%) Query: 126 NHEGEVNRARY------MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRG 179 H + + P + +A+ + + ++D + + G Sbjct: 227 GHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQ----------YTMSG 276 Query: 180 HQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW 239 H + W G L S S D T+ +WDIN+ + ++ + + H ++ D A Sbjct: 277 HTNSVSCVKWG--GQGLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYAL 334 Query: 240 --------------------------------HLLHESLFGSVADDQKLMIWDTRNNNTS 267 + E + + +DD + +W+ ++ Sbjct: 335 RIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPL--KST 392 Query: 268 KPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQV 327 KP + H VN ++F+P +I+ + S D ++ LWD R+ K + +F H ++QV Sbjct: 393 KPIARMTGHQKLVNHVAFSPDGRYIV-SASFDNSIKLWDGRDGKF-ISTFRGHVASVYQV 450 Query: 328 QWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWN 387 WS + +L S D L VWD+ +L GH ++ W+ Sbjct: 451 AWS-SDCRLLVSCSKDTTLKVWDVRT--------------RKLSVDLPGHKDEVYTVDWS 495 Query: 388 PNEPWIICSVSEDNIMQVW 406 + + CS +D ++++W Sbjct: 496 VDGKRV-CSGGKDKMVRLW 513 Score = 168 bits (425), Expect = 5e-42, Method: Composition-based stats. Identities = 76/348 (21%), Positives = 127/348 (36%), Gaps = 84/348 (24%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H V + P + VIAT + + + ++D SG+C D LRGH K Sbjct: 184 GHYNWVLCVSWSP-DGEVIATGSMDNTIRLWD--------PKSGQCLGDA-LRGHSKWIT 233 Query: 186 GLSW------NPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW 239 LSW P L S+S D TI +WD + ++ +GHT V V W Sbjct: 234 SLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQY-------TMSGHTNSVSCVKW 286 Query: 240 HLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSF-------------- 285 + L S + D+ + +WD N+ + + + +H VN LS Sbjct: 287 --GGQGLLYSGSHDRTVRVWDI--NSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHT 342 Query: 286 ------------------------NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHK 321 N SE ++ T S D T+ LW+ + H+ Sbjct: 343 GKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQ 402 Query: 322 DEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKI 381 + V +SP I+ S+ D + +WD + + GH A + Sbjct: 403 KLVNHVAFSPDGRYIV-SASFDNSIKLWDGRDG--------------KFISTFRGHVASV 447 Query: 382 SDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETNT 429 +W+ + ++ S S+D ++VW + ++P + E T Sbjct: 448 YQVAWSSDCR-LLVSCSKDTTLKVWDVRTR---KLSVDLPGHKDEVYT 491 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 57/326 (17%), Positives = 121/326 (37%), Gaps = 80/326 (24%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H + + + P + + T + ++D P L+GH Sbjct: 141 GHGSTILCSAFAPHTSSRMVTGAGDNTARIWD----------CDTQTPMHTLKGHYNWVL 190 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLH-- 243 +SW+P+ + + S D+TI LWD + + GH+ + ++W +H Sbjct: 191 CVSWSPD-GEVIATGSMDNTIRLWDPKSGQCLG------DALRGHSKWITSLSWEPIHLV 243 Query: 244 ----ESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSAD 299 + S + D + IWDT + +T+ HT V+C+ + + +L +GS D Sbjct: 244 KPGSKPRLASSSKDGTIKIWDT---VSRVCQYTMSGHTNSVSCVKW--GGQGLLYSGSHD 298 Query: 300 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPH--------------------------- 332 +TV +WD+ + ++ +SH + + S Sbjct: 299 RTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALE 358 Query: 333 -----------NETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKI 381 +E ++ ++ D + +W+ K + + GH + Sbjct: 359 NYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKP-------------IARMTGHQKLV 405 Query: 382 SDFSWNPNEPWIICSVSEDNIMQVWQ 407 + +++P+ +I+ S S DN +++W Sbjct: 406 NHVAFSPDGRYIV-SASFDNSIKLWD 430 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 58/240 (24%), Positives = 93/240 (38%), Gaps = 31/240 (12%) Query: 202 DDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDT 261 +D L+ A K V + + GH + + A+ S + A D IWD Sbjct: 114 EDQITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDC 173 Query: 262 RNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHK 321 +T P HT+ H V C+S++P E ++ATGS D T+ LWD ++ + + H Sbjct: 174 ---DTQTPMHTLKGHYNWVLCVSWSPDGE-VIATGSMDNTIRLWDPKSGQCLGDALRGHS 229 Query: 322 DEIFQVQWSPHN------ETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHG 375 I + W P + + LASS D + +WD + Sbjct: 230 KWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVS--------------RVCQYTMS 275 Query: 376 GHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE-----NVYNDEEPEIPASELETNTA 430 GHT +S W ++ S S D ++VW + N+ + L T+ A Sbjct: 276 GHTNSVSCVKW--GGQGLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYA 333 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 26/158 (16%), Positives = 53/158 (33%), Gaps = 31/158 (19%) Query: 53 WLP-DVTKQDGKDYSVHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGG 111 W P TK + +L+ S + +++ AS +D G+F Sbjct: 386 WNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASF-------DNSIKLWDGRDGKF-- 436 Query: 112 FGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGEC 171 I H V + + + ++ + + + + V+D Sbjct: 437 ---------ISTFRGHVASVYQVAW-SSDCRLLVSCSKDTTLKVWDVR----------TR 476 Query: 172 QPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLW 209 + + L GH+ E Y + W+ + + S D + LW Sbjct: 477 KLSVDLPGHKDEVYTVDWSVD-GKRVCSGGKDKMVRLW 513 >1VYH-C nrPDB Length = 410 Score = 168 bits (424), Expect = 5e-42, Method: Composition-based stats. Identities = 59/302 (19%), Positives = 109/302 (36%), Gaps = 59/302 (19%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H V + + ++A+ + + ++D+ EC + GH Sbjct: 148 GHTDSVQDISF-DHSGKLLASCSADMTIKLWDFQ--------GFEC--IRTMHGHDHNVS 196 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 +S PN +++SAS D TI +W++ FTGH V V + Sbjct: 197 SVSIMPN-GDHIVSASRDKTIKMWEVQTGY-------CVKTFTGHREWVRMVRPNQDGT- 247 Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEF-------------- 291 L S ++DQ + +W T + + H V C+S+ P S + Sbjct: 248 LIASCSNDQTVRVW---VVATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKS 304 Query: 292 -----ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 346 L +GS DKT+ +WD+ L + H + + V + + S D+ L Sbjct: 305 GKPGPFLLSGSRDKTIKMWDVSTGMC-LMTLVGHDNWVRGVLFH-SGGKFILSCADDKTL 362 Query: 347 HVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 VWD + H ++ ++ P+++ + S D ++VW Sbjct: 363 RVWDYKN--------------KRCMKTLNAHEHFVTSLDFHKTAPYVV-TGSVDQTVKVW 407 Query: 407 QM 408 + Sbjct: 408 EC 409 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 60/322 (18%), Positives = 108/322 (33%), Gaps = 63/322 (19%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H V R + P V+ + + + + V+DY + L+GH Sbjct: 106 GHRSPVTRVIFHPVF-SVMVSASEDATIKVWDYETGD----------FERTLKGHTDSVQ 154 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 +S++ + L S S D TI LWD + GH V V+ + Sbjct: 155 DISFD-HSGKLLASCSADMTIKLWDFQG-------FECIRTMHGHDHNVSSVSIMPNGDH 206 Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 305 S + D+ + +W+ T T H V + N I A+ S D+TV +W Sbjct: 207 -IVSASRDKTIKMWEV---QTGYCVKTFTGHREWVRMVRPNQDGTLI-ASCSNDQTVRVW 261 Query: 306 DLRNLKLKLHSFESHKDEIFQVQWSPHNET-------------------ILASSGTDRRL 346 + + K H+ + + W+P + L S D+ + Sbjct: 262 VVATKECK-AELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTI 320 Query: 347 HVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 +WD+S L GH + ++ +I+ S ++D ++VW Sbjct: 321 KMWDVSTGM--------------CLMTLVGHDNWVRGVLFHSGGKFIL-SCADDKTLRVW 365 Query: 407 QMAE----NVYNDEEPEIPASE 424 N E + + + Sbjct: 366 DYKNKRCMKTLNAHEHFVTSLD 387 Score = 163 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 50/241 (20%), Positives = 108/241 (44%), Gaps = 22/241 (9%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 L GH+ + ++P + ++SAS+D TI +WD D + GHT V+D Sbjct: 104 LSGHRSPVTRVIFHPVFS-VMVSASEDATIKVWDYETG-------DFERTLKGHTDSVQD 155 Query: 237 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATG 296 +++ L S + D + +WD + T+ H V+ +S P + I+ + Sbjct: 156 ISFD-HSGKLLASCSADMTIKLWDF---QGFECIRTMHGHDHNVSSVSIMPNGDHIV-SA 210 Query: 297 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGE 356 S DKT+ +W+++ + +F H++ + V+ + T++AS D+ + VW ++ Sbjct: 211 SRDKTIKMWEVQTGYC-VKTFTGHREWVRMVRPNQDG-TLIASCSNDQTVRVWVVATKEC 268 Query: 357 EQSTEDAEDGPPELLFIHGGHTAKISDFSWNPN------EPWIICSVSEDNIMQVWQMAE 410 + + + + + IS+ + + P+++ S S D +++W ++ Sbjct: 269 KAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLL-SGSRDKTIKMWDVST 327 Query: 411 N 411 Sbjct: 328 G 328 Score = 139 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 42/257 (16%), Positives = 91/257 (35%), Gaps = 44/257 (17%) Query: 115 VCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPD 174 G I H+ V+ MP ++ + + + +++ Sbjct: 179 FQGFECIRTMHGHDHNVSSVSIMPNGDHIV-SASRDKTIKMWEV----------QTGYCV 227 Query: 175 LRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVV 234 GH++ + N + + S S+D T+ +W + + K H VV Sbjct: 228 KTFTGHREWVRMVRPNQD-GTLIASCSNDQTVRVWVVATK-------ECKAELREHRHVV 279 Query: 235 EDVAWHLLHES-------------------LFGSVADDQKLMIWDTRNNNTSKPSHTVDA 275 E ++W S + D+ + +WD +T T+ Sbjct: 280 ECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV---STGMCLMTLVG 336 Query: 276 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET 335 H V + F+ +FIL + + DKT+ +WD +N + + +H+ + + + Sbjct: 337 HDNWVRGVLFHSGGKFIL-SCADDKTLRVWDYKNKRCM-KTLNAHEHFVTSLDFHKTAPY 394 Query: 336 ILASSGTDRRLHVWDLS 352 ++ + D+ + VW+ Sbjct: 395 VV-TGSVDQTVKVWECR 410 Score = 98.7 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 30/154 (19%), Positives = 60/154 (38%), Gaps = 22/154 (14%) Query: 271 HTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWS 330 + + H + V + F+P ++ + S D T+ +WD + + + H D + + + Sbjct: 102 YALSGHRSPVTRVIFHPVFS-VMVSASEDATIKVWDYETGDFE-RTLKGHTDSVQDISFD 159 Query: 331 PHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNE 390 H+ +LAS D + +WD E + GH +S S PN Sbjct: 160 -HSGKLLASCSADMTIKLWDFQGF--------------ECIRTMHGHDHNVSSVSIMPNG 204 Query: 391 PWIICSVSEDNIMQVWQMAEN----VYNDEEPEI 420 I+ S S D +++W++ + + Sbjct: 205 DHIV-SASRDKTIKMWEVQTGYCVKTFTGHREWV 237 >5G04-R nrPDB Length = 499 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 56/279 (20%), Positives = 106/279 (37%), Gaps = 26/279 (9%) Query: 106 KGEFGGFGSVCGKIEI------EIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYT 159 +G + G+ ++++ + N R + N+ ++++ + S + D Sbjct: 237 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVR 296 Query: 160 KHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHR 219 L GH +E GL W P+ +L S +D+ + +W + P E Sbjct: 297 VAE---------HHVATLSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWP--SAPGEGG 344 Query: 220 VIDAKNIFTGHTAVVEDVAWHLLHESLFGSVA--DDQKLMIWDTRNNNTSKPSHTVDAHT 277 + FT H V+ VAW ++ + D+ + IW+ + VDAH+ Sbjct: 345 WV-PLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV---CSGACLSAVDAHS 400 Query: 278 AEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL 337 + L Y E I G A + +W + K+ + H + + SP T+ Sbjct: 401 QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA-KVAELKGHTSRVLSLTMSPDGATV- 458 Query: 338 ASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGG 376 AS+ D L +W ++ + E + + IH G Sbjct: 459 ASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 Score = 139 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 60/321 (18%), Positives = 126/321 (39%), Gaps = 45/321 (14%) Query: 114 SVCGKIEIEIKINHEGE-VNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQ 172 + G I +++ GE ++ ++ + +A T S++V ++D + Q Sbjct: 211 ASSGDILQLLQMEQPGEYISSVAWI-KEGNYLAVGTSSAEVQLWDV-----------QQQ 258 Query: 173 PDLR-LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHT 231 LR + H LSWN + L S S I D+ +GH+ Sbjct: 259 KRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAE------HHVATLSGHS 309 Query: 232 AVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTS-KPSHTVDAHTAEVNCLSFNPYSE 290 V + W L S +D + +W + P T H V +++ P+ Sbjct: 310 QEVCGLRWAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS 368 Query: 291 FILATGS--ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG-TDRRLH 347 +LATG +D+ + +W++ + L + ++H + + WSPH + +++ G +L Sbjct: 369 NVLATGGGTSDRHIRIWNVCSGAC-LSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLV 426 Query: 348 VWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 +W + + + GHT+++ + +P+ + S + D +++W+ Sbjct: 427 IWKYPTMAK--------------VAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLWR 471 Query: 408 MAENVYNDEEPEIPASELETN 428 E AS +++ Sbjct: 472 CFELDPARRREREKASAAKSS 492 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 43/227 (18%), Positives = 90/227 (39%), Gaps = 28/227 (12%) Query: 187 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 246 + W+ +G +L+ + D+++ LW ++ I + VAW + + Sbjct: 190 VDWS---SGNVLAVALDNSVYLWSASSGD-----ILQLLQMEQPGEYISSVAW-IKEGNY 240 Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 ++ +WD + K + +H+A V LS+N +IL++GS + D Sbjct: 241 LAVGTSSAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHD 294 Query: 307 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 366 +R + + + H E+ ++W+P LAS G D ++VW +G Sbjct: 295 VRVAEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW----------PSAPGEG 343 Query: 367 PPELLFIHGGHTAKISDFSWNPNEPWIICSVS--EDNIMQVWQMAEN 411 L H + +W P + ++ + D +++W + Sbjct: 344 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG 390 >4V7E-Bg nrPDB Length = 380 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 64/286 (22%), Positives = 116/286 (40%), Gaps = 27/286 (9%) Query: 127 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 186 H V + P N +A S +F+ + S+ + G L GH+ Sbjct: 107 HCPWVMECAFAP-NGQSVACGGLDSACSIFNLS---SQADRDGNMPVSRVLTGHKGYASS 162 Query: 187 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 246 + P+ L++ S D T LWD+ + I +GHTA V ++ + L+ ++ Sbjct: 163 CQYVPDQETRLITGSGDQTCVLWDVTTGQR--ISIFGSEFPSGHTADVLSLSINSLNANM 220 Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 F S + D + +WD R TS+ T H ++N + F P + TGS D T L+D Sbjct: 221 FISGSCDTTVRLWDLRI--TSRAVRTYHGHEGDINSVKFFPDGQR-FGTGSDDGTCRLFD 277 Query: 307 LRNLK-LKLHSFESHKDE-----IFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 360 +R L++++ E +++ + V +S + A +VWD Sbjct: 278 MRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSN-GDCYVWDTL-------- 328 Query: 361 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 + L + H +IS + + +C+ S D +++W Sbjct: 329 --LAEMVLNLGTLQNSHEGRISCLGLSSDGS-ALCTGSWDKNLKIW 371 Score = 148 bits (373), Expect = 5e-36, Method: Composition-based stats. Identities = 52/315 (16%), Positives = 110/315 (34%), Gaps = 23/315 (7%) Query: 95 AQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVL 154 D Y +G + + H G+V + P+ ++ + + ++ Sbjct: 33 LDTDVEKYSKAQGRTAVSFNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIV-SASQDGRLI 91 Query: 155 VFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINAT 214 V++ Q ++ H ++ PN + D ++++++ Sbjct: 92 VWNALTS----------QKTHAIKLHCPWVMECAFAPN-GQSVACGGLDSACSIFNLSSQ 140 Query: 215 PKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKP--SHT 272 + + TGH + E+ + + DQ ++WD S Sbjct: 141 ADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEF 200 Query: 273 VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPH 332 HTA+V LS N + + +GS D TV LWDLR + ++ H+ +I V++ P Sbjct: 201 PSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFPD 260 Query: 333 NETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 392 + + D ++D+ + Q D L I ++ +++ + Sbjct: 261 GQR-FGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPI-------VTSVAFSISGRL 312 Query: 393 IICSVSEDNIMQVWQ 407 + S + VW Sbjct: 313 LFAGYS-NGDCYVWD 326 Score = 116 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 47/217 (21%), Positives = 87/217 (40%), Gaps = 25/217 (11%) Query: 217 EHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAH 276 + GH+ V + W ++ S + D +L++W+ TS+ +H + H Sbjct: 52 NPTDLVCCRTLQGHSGKVYSLDWTP-EKNWIVSASQDGRLIVWNAL---TSQKTHAIKLH 107 Query: 277 TAEVNCLSFNPYSEFILATGSADKTVALWDL-----RNLKLKLH-SFESHKDEIFQVQWS 330 V +F P + +A G D ++++L R+ + + HK Q+ Sbjct: 108 CPWVMECAFAPNGQS-VACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYV 166 Query: 331 PHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNE 390 P ET L + D+ +WD++ G+ S +E GHTA + S N Sbjct: 167 PDQETRLITGSGDQTCVLWDVTT-GQRISIFGSE--------FPSGHTADVLSLSINSLN 217 Query: 391 PWIICSVSEDNIMQVWQM-----AENVYNDEEPEIPA 422 + S S D +++W + A Y+ E +I + Sbjct: 218 ANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINS 254 Score = 94.1 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 43/249 (17%), Positives = 78/249 (31%), Gaps = 73/249 (29%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H+G + +Y+P + T + +++D T E GH + Sbjct: 155 GHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFP-----SGHTADVL 209 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 LS N +S S D T+ LWD+ T + A + GH + V + + Sbjct: 210 SLSINSLNANMFISGSCDTTVRLWDLRITSR------AVRTYHGHEGDINSVKFFPDGQR 263 Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSH---------------------------------- 271 FG+ +DD ++D R + + + Sbjct: 264 -FGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDC 322 Query: 272 ----------------TVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 315 ++H ++CL + L TGS DK + +W Sbjct: 323 YVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSDGS-ALCTGSWDKNLKIW---------- 371 Query: 316 SFESHKDEI 324 +F H+ + Sbjct: 372 AFSGHRKIV 380 >4A11-B nrPDB Length = 408 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 57/238 (23%), Positives = 96/238 (40%), Gaps = 16/238 (6%) Query: 180 HQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTG------HTAV 233 H L P Y+LS D I L+D+ + ++ G H Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 234 VEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP--YSEF 291 VE V W+ +F S + D+ L +WDT T+ + + V +P Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEET----VYSHHMSPVSTKHC 157 Query: 292 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 ++A G+ V L DL++ H + H+ EI V WSP + ILA++ D R+ +WD+ Sbjct: 158 LVAVGTRGPKVQLCDLKSGSCS-HILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 Query: 352 SKIGEEQSTEDAEDGPPELLFIH--GGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 + T D +G H K++ + + ++ +V DN M++W Sbjct: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLL-TVGTDNRMRLWN 273 Score = 87.5 bits (215), Expect = 9e-18, Method: Composition-based stats. Identities = 39/202 (19%), Positives = 70/202 (34%), Gaps = 47/202 (23%) Query: 276 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH------------SFESHKDE 323 H +N L P + +G +D + L+DL N + + + H+ Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 324 IFQVQWSPHNETILASSGTDRRLHVWDLSKIGE------EQSTEDAEDGPPE-------- 369 + VQW PH+ + SS D+ L VWD + + E++ P Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 Query: 370 ----------------LLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN-- 411 I GH +I SW+P +I+ + S D+ +++W + Sbjct: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASG 221 Query: 412 ---VYNDEEPEIPASELETNTA 430 + + + NTA Sbjct: 222 CLITLDQHNGKKSQAVESANTA 243 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 49/306 (16%), Positives = 97/306 (31%), Gaps = 34/306 (11%) Query: 50 TAQWLPDVTKQDGKDYSVHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEF 109 T QW P T L + + N L A V E + K Sbjct: 104 TVQWYPHDTGMFTSSSFDKTLKVW-----DTNTLQTADVFNFEETVYSHHMSPVSTKHCL 158 Query: 110 GGFGSVCGKIEI---------EIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTK 160 G+ K+++ I H E+ + P+ ++AT + S V ++D + Sbjct: 159 VAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRR 218 Query: 161 HPS---KPEPSGECQPDLRLR---GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINAT 214 + + H + GL + + +LL+ D+ + LW+ + Sbjct: 219 ASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD-GLHLLTVGTDNRMRLWNSSNG 277 Query: 215 PKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVD 274 + ++ S F V + ++ + + + Sbjct: 278 E---NTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVY---TVYSGEQITMLK 331 Query: 275 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL-----HSFESHKDEIFQVQW 329 H V+C F + L +GS D + W + +L + + +S + F+ W Sbjct: 332 GHYKTVDCCVFQSNFQE-LYSGSRDCNILAW-VPSLYEPVPDDDETTTKSQLNPAFEDAW 389 Query: 330 SPHNET 335 S +E Sbjct: 390 SSSDEE 395 >5WYJ-BC nrPDB Length = 817 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 66/311 (21%), Positives = 125/311 (40%), Gaps = 42/311 (13%) Query: 116 CGKIEIEIKI-NHEGEVNRARYMPQ--NACVIATKTPSSDVLVFDYTKHPSKPEPSGECQ 172 I++ I + G + RY+ N +AT +PS ++ P P Sbjct: 324 EDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPV-----PDLSGPEASLP 378 Query: 173 PDLRL-RGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHT 231 D+ + GH+ L ++ +AS D+T +W N + D + GH+ Sbjct: 379 LDVEIYEGHEDLLNSLD-ATEDGLWIATASKDNTAIVWRYNENSCK---FDIYAKYIGHS 434 Query: 232 AVVEDVAW----HLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVD-------AHTAEV 280 A V V + + ++D + W S + AH ++ Sbjct: 435 AAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDI 494 Query: 281 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 340 N LS +P ++ I AT S DKT +W+L N +L+ + +HK ++ V + +++ +LA+S Sbjct: 495 NALSVSP-NDSIFATASYDKTCKIWNLENGELE-ATLANHKRGLWDVSFCQYDK-LLATS 551 Query: 341 GTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSED 400 D+ + +W L ++ E GHT + S+ + +I S D Sbjct: 552 SGDKTVKIWSLDTFSVMKTLE--------------GHTNAVQRCSFINKQKQLI-SCGAD 596 Query: 401 NIMQVWQMAEN 411 ++++W + Sbjct: 597 GLIKIWDCSSG 607 Score = 139 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 62/296 (20%), Positives = 119/296 (40%), Gaps = 36/296 (12%) Query: 119 IEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLR 178 +++EI HE +N ++ IAT + + +V+ Y ++ K + + Sbjct: 379 LDVEIYEGHEDLLNSLD-ATEDGLWIATASKDNTAIVWRYNENSCKFD------IYAKYI 431 Query: 179 GHQKEGYGLSW----NPNLNGYLLSASDDHTICLW---DINATPKEHRVIDAKNIFTGHT 231 GH + + +LL+AS+D TI W A+ + ++ H Sbjct: 432 GHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHE 491 Query: 232 AVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEF 291 + ++ ++S+F + + D+ IW+ N + T+ H + +SF Y + Sbjct: 492 KDINALSVSP-NDSIFATASYDKTCKIWNLEN---GELEATLANHKRGLWDVSFCQYDK- 546 Query: 292 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 +LAT S DKTV +W L + + E H + + + + + ++ S G D + +WD Sbjct: 547 LLATSSGDKTVKIWSLDTFSVM-KTLEGHTNAVQRCSFINKQKQLI-SCGADGLIKIWDC 604 Query: 352 SKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 S E L GH ++ S + +I S D + Q W+ Sbjct: 605 SSG--------------ECLKTLDGHNNRLWALSTMNDG-DMIVSADADGVFQFWK 645 Score = 67.9 bits (164), Expect = 8e-12, Method: Composition-based stats. Identities = 56/303 (18%), Positives = 100/303 (33%), Gaps = 41/303 (13%) Query: 126 NHEGEVNRARYMPQNA---CVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQK 182 H G ++ ++ Q ++A+ + V V+D K L+ H Sbjct: 142 GHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLH----------TLQEHTS 191 Query: 183 EGYGLSW--NPNLNG---YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDV 237 GL P+ + LLS D I LWD N K + VE Sbjct: 192 AVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQ-----VESC 246 Query: 238 AWHLLHES--LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILAT 295 + + + + D + D+ + + K ++ + L S+ L Sbjct: 247 GFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVLPILSNSQMFLVL 306 Query: 296 GSADKTVALW----DLRNLKLKLH---SFESHKDEIFQVQWSPHNETILASSGTDRRLHV 348 D+T+ L DL+N + + S + I +++ LA + L + Sbjct: 307 S--DQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRI 364 Query: 349 WDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 E P + I+ GH ++ + W I + S+DN VW+ Sbjct: 365 ------IPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLW-IATASKDNTAIVWRY 417 Query: 409 AEN 411 EN Sbjct: 418 NEN 420 Score = 57.9 bits (138), Expect = 8e-09, Method: Composition-based stats. Identities = 37/178 (20%), Positives = 69/178 (38%), Gaps = 32/178 (17%) Query: 241 LLHESLFGSVADDQKLMIWDTRNNNTSK------PSHTVDAHTAEVNCLSFNPYSEFILA 294 V+ Q L I+ + + PS+ +DA + + +LA Sbjct: 70 TPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKISSPSYILDADS-----------TSTLLA 118 Query: 295 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQW---SPHNETILASSGTDRRLHVWDL 351 G D ++ + D+ N + HSF+ H I +++ +LAS T+ + VWDL Sbjct: 119 VGGTDGSIIVVDIENGYI-THSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDL 177 Query: 352 SKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWI-ICSVSEDNIMQVWQM 408 K + ++ L I ++ D +EP + + S D+I+ +W Sbjct: 178 VKRKCLHTLQEHTSAVRGLDII------EVPD----NDEPSLNLLSGGRDDIINLWDF 225 Score = 52.1 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 30/180 (16%), Positives = 61/180 (33%), Gaps = 22/180 (12%) Query: 235 EDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILA 294 VA + + + D+ + I D + + E+ L P +++ Sbjct: 20 SAVATVSENGKILATPVLDE-INIIDLTPGSRKILHKISNEDEQEITALKLTPDGQYLTY 78 Query: 295 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKI 354 S + + ++ L+ K+ S I T+LA GTD + V D+ Sbjct: 79 V-SQAQLLKIFHLKTGKVVRSMKISSPSYILDAD---STSTLLAVGGTDGSIIVVDIENG 134 Query: 355 GEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPN---EPWIICSVSEDNIMQVWQMAEN 411 S + GH IS + + W++ S + +++VW + + Sbjct: 135 YITHSFK--------------GHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKR 180 >4GGA-A nrPDB Length = 420 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 56/279 (20%), Positives = 106/279 (37%), Gaps = 26/279 (9%) Query: 106 KGEFGGFGSVCGKIEI------EIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYT 159 +G + G+ ++++ + N R + N+ ++++ + S + D Sbjct: 158 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVR 217 Query: 160 KHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHR 219 L GH +E GL W P+ +L S +D+ + +W + P E Sbjct: 218 VAE---------HHVATLSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWP--SAPGEGG 265 Query: 220 VIDAKNIFTGHTAVVEDVAWHLLHESLFGSVA--DDQKLMIWDTRNNNTSKPSHTVDAHT 277 + FT H V+ VAW ++ + D+ + IW+ + VDAH+ Sbjct: 266 WV-PLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV---CSGACLSAVDAHS 321 Query: 278 AEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL 337 + L Y E I G A + +W + K+ + H + + SP T+ Sbjct: 322 QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA-KVAELKGHTSRVLSLTMSPDGATV- 379 Query: 338 ASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGG 376 AS+ D L +W ++ + E + + IH G Sbjct: 380 ASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 418 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 60/321 (18%), Positives = 126/321 (39%), Gaps = 45/321 (14%) Query: 114 SVCGKIEIEIKINHEGE-VNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQ 172 + G I +++ GE ++ ++ + +A T S++V ++D + Q Sbjct: 132 ASSGDILQLLQMEQPGEYISSVAWI-KEGNYLAVGTSSAEVQLWDV-----------QQQ 179 Query: 173 PDLR-LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHT 231 LR + H LSWN + L S S I D+ +GH+ Sbjct: 180 KRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAE------HHVATLSGHS 230 Query: 232 AVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTS-KPSHTVDAHTAEVNCLSFNPYSE 290 V + W L S +D + +W + P T H V +++ P+ Sbjct: 231 QEVCGLRWAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS 289 Query: 291 FILATGS--ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG-TDRRLH 347 +LATG +D+ + +W++ + L + ++H + + WSPH + +++ G +L Sbjct: 290 NVLATGGGTSDRHIRIWNVCSGAC-LSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLV 347 Query: 348 VWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 +W + + + GHT+++ + +P+ + S + D +++W+ Sbjct: 348 IWKYPTMAK--------------VAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLWR 392 Query: 408 MAENVYNDEEPEIPASELETN 428 E AS +++ Sbjct: 393 CFELDPARRREREKASAAKSS 413 Score = 102 bits (253), Expect = 4e-22, Method: Composition-based stats. Identities = 43/227 (18%), Positives = 90/227 (39%), Gaps = 28/227 (12%) Query: 187 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 246 + W+ +G +L+ + D+++ LW ++ I + VAW + + Sbjct: 111 VDWS---SGNVLAVALDNSVYLWSASSGD-----ILQLLQMEQPGEYISSVAW-IKEGNY 161 Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 ++ +WD + K + +H+A V LS+N +IL++GS + D Sbjct: 162 LAVGTSSAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHD 215 Query: 307 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 366 +R + + + H E+ ++W+P LAS G D ++VW +G Sbjct: 216 VRVAEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW----------PSAPGEG 264 Query: 367 PPELLFIHGGHTAKISDFSWNPNEPWIICSVS--EDNIMQVWQMAEN 411 L H + +W P + ++ + D +++W + Sbjct: 265 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG 311 >3JRO-A nrPDB Length = 753 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 108/295 (36%), Gaps = 47/295 (15%) Query: 144 IATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW-NPNLNGYLLSASD 202 +AT + + +F+ K + L GH+ + + W +P L S S Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDT--------LTGHEGPVWRVDWAHPKFGTILASCSY 75 Query: 203 DHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLH-ESLFGSVADDQKLMIWDT 261 D + +W +E+ + H+A V V W L + D K+ + + Sbjct: 76 DGKVLIW-----KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEF 130 Query: 262 RNNNTSKPSHTVDAHTAEVNCLSFNP------------YSEFILATGSADKTVALWDLRN 309 + N T+ P +DAH VN S+ P TG AD V +W + Sbjct: 131 KENGTTSPI-IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNS 189 Query: 310 LKLKL---HSFESHKDEIFQVQWSPHN--ETILASSGTDRRLHVWDLSKIGEEQSTEDAE 364 + E H D + V WSP + LAS DR +W T+D E Sbjct: 190 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW----------TQDNE 239 Query: 365 DGPPELLFIHGGHTAKI-SDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEP 418 GP + + + SW+ + + S DN + +W+ EN+ EP Sbjct: 240 QGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGG-DNKVTLWK--ENLEGKWEP 291 Score = 121 bits (303), Expect = 7e-28, Method: Composition-based stats. Identities = 50/250 (20%), Positives = 88/250 (35%), Gaps = 35/250 (14%) Query: 121 IEIKINHEGEVNRARY-MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRG 179 I+ HEG V R + P+ ++A+ + VL++ E +G Sbjct: 46 IDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK--------EENGRWSQIAVHAV 97 Query: 180 HQKEGYGLSWNPNL-NGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 H + W P+ LL AS D + + + +I H V + Sbjct: 98 HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII-----IDAHAIGVNSAS 152 Query: 239 WHL------------LHESLFGSVADDQKLMIWDT-RNNNTSKPSHTVDAHTAEVNCLSF 285 W F + D + IW + T T++ H+ V +++ Sbjct: 153 WAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAW 212 Query: 286 NPY--SEFILATGSADKTVALW--DLRNLKLKLHSFESHKDE--IFQVQWSPHNETILAS 339 +P LA+ S D+T +W D K + K +++ WS +LA Sbjct: 213 SPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSG-NVLAL 271 Query: 340 SGTDRRLHVW 349 SG D ++ +W Sbjct: 272 SGGDNKVTLW 281 >5Y88-O nrPDB Length = 451 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 59/248 (23%), Positives = 108/248 (43%), Gaps = 30/248 (12%) Query: 164 KPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDA 223 +PE + + GH ++ +P N + ++ S+D T+ +WD+ Sbjct: 122 RPEWHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATG-------KL 174 Query: 224 KNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCL 283 K GH V DVA H LF SV++D+ + WD N + + H + V + Sbjct: 175 KTTLAGHVMTVRDVAVSDRHPYLF-SVSEDKTVKCWDLEKNQIIRDYY---GHLSGVRTV 230 Query: 284 SFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTD 343 S +P + I AT D + LWD+R ++ + + HK I QVQ +P + ++ SS TD Sbjct: 231 SIHPTLDLI-ATAGRDSVIKLWDMRT-RIPVITLVGHKGPINQVQCTPVDPQVV-SSSTD 287 Query: 344 RRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIM 403 + +WD+ + + + H + + +P E + + ++D + Sbjct: 288 ATVRLWDV--------------VAGKTMKVLTHHKRSVRATALHPKEFSVASACTDD--I 331 Query: 404 QVWQMAEN 411 + W +AE Sbjct: 332 RSWGLAEG 339 Score = 124 bits (312), Expect = 5e-29, Method: Composition-based stats. Identities = 56/286 (19%), Positives = 104/286 (36%), Gaps = 41/286 (14%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H G V P + T + + + V+D + L GH Sbjct: 137 GHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDL----------ATGKLKTTLAGHVMTVR 186 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 ++ + + + YL S S+D T+ WD+ + GH + V V+ H Sbjct: 187 DVAVS-DRHPYLFSVSEDKTVKCWDLEKNQ-------IIRDYYGHLSGVRTVSIHPT-LD 237 Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 305 L + D + +WD R T P T+ H +N + P ++++ S D TV LW Sbjct: 238 LIATAGRDSVIKLWDMR---TRIPVITLVGHKGPINQVQCTPVDPQVVSS-STDATVRLW 293 Query: 306 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED 365 D+ K + HK + P ++ AS+ TD + W L++ + E + Sbjct: 294 DVVAGKT-MKVLTHHKRSVRATALHPKEFSV-ASACTDD-IRSWGLAEGSLLTNFESEK- 349 Query: 366 GPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 T I+ S N + ++ + ++ ++ + Sbjct: 350 ------------TGIINTLSINQD--DVLFAGGDNGVLSFYDYKSG 381 Score = 119 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 41/201 (20%), Positives = 80/201 (39%), Gaps = 21/201 (10%) Query: 211 INATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPS 270 ++ P+ H + GH V VA + F + ++D + +WD T K Sbjct: 119 LSQRPEWHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDL---ATGKLK 175 Query: 271 HTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWS 330 T+ H V ++ + ++ + S DKTV WDL ++ + + H + V Sbjct: 176 TTLAGHVMTVRDVAVSDRHPYLFSV-SEDKTVKCWDLEKNQI-IRDYYGHLSGVRTVSIH 233 Query: 331 PHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNE 390 P + ++A++G D + +WD+ + GH I+ P + Sbjct: 234 PTLD-LIATAGRDSVIKLWDMRTRIPVITLV--------------GHKGPINQVQCTPVD 278 Query: 391 PWIICSVSEDNIMQVWQMAEN 411 P ++ S S D +++W + Sbjct: 279 PQVV-SSSTDATVRLWDVVAG 298 Score = 64.8 bits (156), Expect = 6e-11, Method: Composition-based stats. Identities = 34/235 (14%), Positives = 82/235 (34%), Gaps = 37/235 (15%) Query: 104 NEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPS 163 + + +I + + H+G +N+ + P + V+++ + + V ++D + Sbjct: 242 AGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSS-STDATVRLWDVVAGKT 300 Query: 164 KPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDA 223 L H++ + +P + +DD I W + Sbjct: 301 MK----------VLTHHKRSVRATALHPKEFSVASACTDD--IRSWGLAEGSLLTNFESE 348 Query: 224 KNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHT------VDAHT 277 K T ++ ++ + + + D+ L +D ++ + + T ++ Sbjct: 349 K------TGIINTLSINQDD--VLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEG-E 399 Query: 278 AEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPH 332 V C +F+ L TG ADK++ +W K + W+P+ Sbjct: 400 RSVLCSTFDKTG-LRLITGEADKSIKIWKQDETATKESEPG--------LAWNPN 445 >5LCW-Q nrPDB Length = 374 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 56/279 (20%), Positives = 106/279 (37%), Gaps = 26/279 (9%) Query: 106 KGEFGGFGSVCGKIEI------EIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYT 159 +G + G+ ++++ + N R + N+ ++++ + S + D Sbjct: 112 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVR 171 Query: 160 KHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHR 219 L GH +E GL W P+ +L S +D+ + +W + P E Sbjct: 172 VAE---------HHVATLSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWP--SAPGEGG 219 Query: 220 VIDAKNIFTGHTAVVEDVAWHLLHESLFGSVA--DDQKLMIWDTRNNNTSKPSHTVDAHT 277 + FT H V+ VAW ++ + D+ + IW+ + VDAH+ Sbjct: 220 WV-PLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV---CSGACLSAVDAHS 275 Query: 278 AEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL 337 + L Y E I G A + +W + K+ + H + + SP T+ Sbjct: 276 QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA-KVAELKGHTSRVLSLTMSPDGATV- 333 Query: 338 ASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGG 376 AS+ D L +W ++ + E + + IH G Sbjct: 334 ASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 372 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 60/321 (18%), Positives = 126/321 (39%), Gaps = 45/321 (14%) Query: 114 SVCGKIEIEIKINHEGE-VNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQ 172 + G I +++ GE ++ ++ + +A T S++V ++D + Q Sbjct: 86 ASSGDILQLLQMEQPGEYISSVAWI-KEGNYLAVGTSSAEVQLWDV-----------QQQ 133 Query: 173 PDLR-LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHT 231 LR + H LSWN + L S S I D+ +GH+ Sbjct: 134 KRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAE------HHVATLSGHS 184 Query: 232 AVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTS-KPSHTVDAHTAEVNCLSFNPYSE 290 V + W L S +D + +W + P T H V +++ P+ Sbjct: 185 QEVCGLRWAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS 243 Query: 291 FILATGS--ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG-TDRRLH 347 +LATG +D+ + +W++ + L + ++H + + WSPH + +++ G +L Sbjct: 244 NVLATGGGTSDRHIRIWNVCSGAC-LSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLV 301 Query: 348 VWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 +W + + + GHT+++ + +P+ + S + D +++W+ Sbjct: 302 IWKYPTMAK--------------VAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLWR 346 Query: 408 MAENVYNDEEPEIPASELETN 428 E AS +++ Sbjct: 347 CFELDPARRREREKASAAKSS 367 Score = 101 bits (252), Expect = 5e-22, Method: Composition-based stats. Identities = 43/227 (18%), Positives = 90/227 (39%), Gaps = 28/227 (12%) Query: 187 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 246 + W+ +G +L+ + D+++ LW ++ I + VAW + + Sbjct: 65 VDWS---SGNVLAVALDNSVYLWSASSGD-----ILQLLQMEQPGEYISSVAW-IKEGNY 115 Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 ++ +WD + K + +H+A V LS+N +IL++GS + D Sbjct: 116 LAVGTSSAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHD 169 Query: 307 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 366 +R + + + H E+ ++W+P LAS G D ++VW +G Sbjct: 170 VRVAEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW----------PSAPGEG 218 Query: 367 PPELLFIHGGHTAKISDFSWNPNEPWIICSVS--EDNIMQVWQMAEN 411 L H + +W P + ++ + D +++W + Sbjct: 219 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG 265 >3W15-A nrPDB Length = 368 Score = 164 bits (414), Expect = 8e-41, Method: Composition-based stats. Identities = 63/308 (20%), Positives = 117/308 (37%), Gaps = 42/308 (13%) Query: 133 RARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPN 192 + + + + +FD T P + H++E + +WN Sbjct: 67 DLAWNESHENQVLVAQGDGTLRLFDTTFKEF---------PIAIFKEHEREVFSCNWNLV 117 Query: 193 LNGYLLSASDDHTICLWD-------INATPKE----------HRVIDAKNIFTG---HTA 232 LS+S D +I +W + TP+ + +I K FTG + Sbjct: 118 NRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRN 177 Query: 233 VVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI 292 V + ++L S + + ++D R + ++ + E FN Y ++ Sbjct: 178 CVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYV 237 Query: 293 LATGSADKTVALWDLR----------NLKLKLHSFESHKDEIFQVQWSPHNETILASSGT 342 +ATG D + +WD+R N +H I +V WSPH+ IL S+ Sbjct: 238 VATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASY 297 Query: 343 DRRLHVW-DLSKIGEEQSTE-DAEDGPPELLFIHGGHTAKISDFSWN-PNEPWIICSVSE 399 D +W DLS G +++ + ++ D +F H+ + W+ +P + S + Sbjct: 298 DMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAW 357 Query: 400 DNIMQVWQ 407 D + VW Sbjct: 358 DGNLFVWN 365 Score = 117 bits (293), Expect = 1e-26, Method: Composition-based stats. Identities = 60/320 (18%), Positives = 115/320 (35%), Gaps = 36/320 (11%) Query: 132 NRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNP 191 +Y P +A S+ LV + + + SG Q + L+WN Sbjct: 14 YGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFL-TQDCLFDLAWNE 72 Query: 192 NLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVA 251 + +L A D T+ L+D IF H V W+L++ F S + Sbjct: 73 SHENQVLVAQGDGTLRLFDTTFKE------FPIAIFKEHEREVFSCNWNLVNRQNFLSSS 126 Query: 252 DDQKLMIWDTRNNN-----TSKPSH----------------TVDAHTAEVNCL---SFNP 287 D + IW T +P + + NC+ F+P Sbjct: 127 WDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP 186 Query: 288 YSEFILATGSADKTVALWDLR-NLKLKLHSFESHKD-EIFQVQWSPHNETILASSGTDRR 345 + + ++ + S + +L+D+R ++F H E ++ + ++A+ G D Sbjct: 187 HDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNA 246 Query: 346 LHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQV 405 + +WD+ + + E I H I +W+P+ I+ S S D ++ Sbjct: 247 IRIWDIRMLNKNPGQLHNSSCINE---IPNAHGLAIRKVTWSPHHSNILMSASYDMTCRI 303 Query: 406 WQMAENVYNDEEPEIPASEL 425 W+ N E + +++ Sbjct: 304 WRDLSNDGAKETYKTNSTDA 323 Score = 101 bits (251), Expect = 7e-22, Method: Composition-based stats. Identities = 59/305 (19%), Positives = 103/305 (33%), Gaps = 52/305 (17%) Query: 93 EDAQFDGSHYDN-----EKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATK 147 D ++ SH + G F + + I I HE EV + N + Sbjct: 66 FDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSS 125 Query: 148 TPSSDVLVFD-------YTKHPSKPEPSGECQP-------DLRLRGHQKEGYGL---SWN 190 + + ++ T P E + P G K + ++ Sbjct: 126 SWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFS 185 Query: 191 PNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTA-VVEDVAWHLLHESLFGS 249 P+ +LS S + L+DI +N F H+ ++ + + Sbjct: 186 PHDQNLVLSCSGNSYASLFDIRLPSG-----KNQNNFLVHSGLEALTCDFNKYRPYVVAT 240 Query: 250 VADDQKLMIWDTRNNNT-------SKPSHTV-DAHTAEVNCLSFNPYSEFILATGSADKT 301 D + IWD R N S + + +AH + ++++P+ IL + S D T Sbjct: 241 GGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMT 300 Query: 302 VALW-DLRNLKLK--------------LHSFESHKDEIFQVQWSPHN-ETILASSGTDRR 345 +W DL N K + +F H + +F WS +AS+ D Sbjct: 301 CRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGN 360 Query: 346 LHVWD 350 L VW+ Sbjct: 361 LFVWN 365 >6HHQ-h nrPDB Length = 319 Score = 164 bits (414), Expect = 9e-41, Method: Composition-based stats. Identities = 53/239 (22%), Positives = 100/239 (41%), Gaps = 29/239 (12%) Query: 176 RLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVE 235 L GH L+ + LLSAS D T+ W + ++ V F GH+ +V+ Sbjct: 12 TLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGV--PVRSFKGHSHIVQ 69 Query: 236 DVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILAT 295 D S + D+ L +WD T + H ++V + + + I+ + Sbjct: 70 DCTLTADGAYAL-SASWDKTLRLWDV---ATGETYQRFVGHKSDVMSVDIDKKASMII-S 124 Query: 296 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP-----HNETILASSGTDRRLHVWD 350 GS DKT+ +W ++ L + H D + QV+ P + + S+G D+ + W+ Sbjct: 125 GSRDKTIKVWTIK--GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWN 182 Query: 351 LSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMA 409 L++ ++ GH + I+ + +P+ +I S +D + +W +A Sbjct: 183 LNQF--------------QIEADFIGHNSNINTLTASPDGT-LIASAGKDGEIMLWNLA 226 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 56/300 (18%), Positives = 110/300 (36%), Gaps = 43/300 (14%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H G V ++ + + ++ + T K P +GH Sbjct: 15 GHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGV-----PVRSFKGHSHIVQ 69 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 + + Y LSAS D T+ LWD+ R F GH + V V S Sbjct: 70 DCTLTAD-GAYALSASWDKTLRLWDVATGETYQR-------FVGHKSDVMSVDID-KKAS 120 Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP-----YSEFILATGSADK 300 + S + D+ + +W + + T+ H V+ + P + + DK Sbjct: 121 MIISGSRDKTIKVWTIK----GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDK 176 Query: 301 TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 360 V W+L +++ F H I + SP T++AS+G D + +W+L+ + Sbjct: 177 MVKAWNLNQFQIE-ADFIGHNSNINTLTASPDG-TLIASAGKDGEIMLWNLAAKKAMYTL 234 Query: 361 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM-AENVYNDEEPE 419 + ++ +++PN W+ + + ++V+ + + + +D PE Sbjct: 235 SAQD---------------EVFSLAFSPNRYWLAAATATG--IKVFSLDPQYLVDDLRPE 277 Score = 30.1 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 20/165 (12%), Positives = 44/165 (26%), Gaps = 41/165 (24%) Query: 90 LPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIK-INHEGEVNRARYMPQNACVIATKT 148 +P+E A D + + + +IE I H +N P + +IA+ Sbjct: 157 VPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASP-DGTLIASAG 215 Query: 149 PSSDVLVFDYTKHPSKPEPSGE--------CQPDLRLRGHQKEG---------------- 184 ++++++ + S + L G Sbjct: 216 KDGEIMLWNLAAKKAMYTLSAQDEVFSLAFSPNRYWLAAATATGIKVFSLDPQYLVDDLR 275 Query: 185 --------------YGLSWNPNLNGYLLSASDDHTICLWDINATP 215 L+W+ + D+ I +W + Sbjct: 276 PEFAGYSKAAEPHAVSLAWSADGQTLFA-GYTDNVIRVWQVMTAN 319 >5GAN-H nrPDB Length = 465 Score = 162 bits (409), Expect = 3e-40, Method: Composition-based stats. Identities = 64/325 (19%), Positives = 131/325 (40%), Gaps = 39/325 (12%) Query: 85 IASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVI 144 I++V L ++D + G+ S + + +H G++ + P + + Sbjct: 178 ISAVSLSTDDMVVATGSWA---GDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQM 234 Query: 145 ATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDH 204 + + F Y+ G+ L GH++ + ++P ++ SAS D Sbjct: 235 ISCAEDGLIKNFQYSNEEGGLRLLGD------LVGHERRISDVKYHP-SGKFIGSASHDM 287 Query: 205 TICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNN 264 T LWD + + + GH V +++ SL S D M+WD R+ Sbjct: 288 TWRLWDASTHQE-------LLLQEGHDKGVFSLSFQCDG-SLVCSGGMDSLSMLWDIRSG 339 Query: 265 NTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN-LKLKLHSFESHKDE 323 + T+ H+ + ++++P + + +ATG D + +WD+R + +L+ +H++ Sbjct: 340 S---KVMTLAGHSKPIYTVAWSP-NGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNI 395 Query: 324 IFQVQWS-PHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKIS 382 + QV++S L S G D ++V+ + GHT KI Sbjct: 396 VTQVRFSKEDGGKKLVSCGYDNLINVYS--------------SDTWLKMGSLAGHTDKII 441 Query: 383 DFSWNPNEPWIICSVSEDNIMQVWQ 407 + N +++ S D +++W Sbjct: 442 SLDISNNSHFLV-SGGWDRSIKLWN 465 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 40/236 (16%), Positives = 86/236 (36%), Gaps = 26/236 (11%) Query: 181 QKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH 240 K +S + + + + S + + + + +D+ H + + WH Sbjct: 175 TKPISAVSLSTDDM-VVATGSWAGDLQVLNSQTLQPLTQKLDS------HVGKIGAIDWH 227 Query: 241 LLHESLFGSVADDQKLMIWDTRNNNTS-KPSHTVDAHTAEVNCLSFNPYSEFILATGSAD 299 + S A+D + + N + + H ++ + ++P +FI + S D Sbjct: 228 PDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFI-GSASHD 286 Query: 300 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQS 359 T LWD +L E H +F + + + +++ S G D +WD+ + + Sbjct: 287 MTWRLWDAST-HQELLLQEGHDKGVFSLSF-QCDGSLVCSGGMDSLSMLWDIRSGSKVMT 344 Query: 360 TEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYND 415 GH+ I +W+PN + + D I+ VW + + Sbjct: 345 L--------------AGHSKPIYTVAWSPNGYQV-ATGGGDGIINVWDIRKRDEGQ 385 >5NZU-C nrPDB Length = 905 Score = 158 bits (400), Expect = 3e-39, Method: Composition-based stats. Identities = 54/298 (18%), Positives = 114/298 (38%), Gaps = 29/298 (9%) Query: 130 EVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW 189 V A+++ + V+ T + VF+Y + H ++ Sbjct: 59 PVRAAKFVARKNWVV-TGADDMQIRVFNYN----------TLERVHMFEAHSDYIRCIAV 107 Query: 190 NPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGS 249 +P ++L++SDD I LWD + + +F GHT V + + + F S Sbjct: 108 HPTQ-PFILTSSDDMLIKLWDWD------KKWSCSQVFEGHTHYVMQIVINPKDNNQFAS 160 Query: 250 VADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSE-FILATGSADKTVALWDLR 308 + D+ + +W +S P+ T++ H VNC+ + + L +G+ D+ V +WD + Sbjct: 161 ASLDRTIKVWQL---GSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQ 217 Query: 309 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPP 368 N + + E H + + P I+ + D + +W S E + + Sbjct: 218 NKTC-VQTLEGHAQNVSCASFHPELP-IIITGSEDGTVRIWHSSTYRLESTLNYGMERVW 275 Query: 369 ELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELE 426 + + G ++ + +E II + + + + E+ + L+ Sbjct: 276 CVASLRGS-----NNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLK 328 Score = 151 bits (382), Expect = 5e-37, Method: Composition-based stats. Identities = 56/267 (20%), Positives = 97/267 (36%), Gaps = 44/267 (16%) Query: 170 ECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTG 229 +L + +P L S + ++C+W+ H F Sbjct: 4 RLDIKRKLTARSDRVKSVDLHPTEPWMLASL-YNGSVCVWN-------HETQTLVKTFEV 55 Query: 230 HTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS 289 V + ++ + ADD ++ +++ NT + H +AH+ + C++ +P Sbjct: 56 CDLPVRAAKFVAR-KNWVVTGADDMQIRVFN---YNTLERVHMFEAHSDYIRCIAVHPTQ 111 Query: 290 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 FIL T S D + LWD FE H + Q+ +P + AS+ DR + VW Sbjct: 112 PFIL-TSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVW 170 Query: 350 DLSKIGEEQSTEDAEDGPPELLFIHG------------------------------GHTA 379 L + E E G + + G GH Sbjct: 171 QLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQ 230 Query: 380 KISDFSWNPNEPWIICSVSEDNIMQVW 406 +S S++P P II + SED +++W Sbjct: 231 NVSCASFHPELP-IIITGSEDGTVRIW 256 Score = 132 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 47/224 (20%), Positives = 84/224 (37%), Gaps = 24/224 (10%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H + P ++ + + + ++D+ K + GH Sbjct: 97 AHSDYIRCIAVHPTQPFILTS-SDDMLIKLWDWDK---------KWSCSQVFEGHTHYVM 146 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 + NP N SAS D TI +W + ++ GH V + ++ + Sbjct: 147 QIVINPKDNNQFASASLDRTIKVWQLGSSSPNF-------TLEGHEKGVNCIDYYSGGDK 199 Query: 246 -LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 304 S ADD+ + IWD +N T++ H V+C SF+P I+ TGS D TV + Sbjct: 200 PYLISGADDRLVKIWDYQN---KTCVQTLEGHAQNVSCASFHPELPIII-TGSEDGTVRI 255 Query: 305 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHV 348 W +L+ + + ++ V S +A + + V Sbjct: 256 WHSSTYRLE-STLNYGMERVWCVA-SLRGSNNVALGYDEGSIIV 297 Score = 30.1 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 7/45 (15%), Positives = 18/45 (40%), Gaps = 1/45 (2%) Query: 369 ELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVY 413 ++ + ++ +P EPW++ S+ + + VW Sbjct: 6 DIKRKLTARSDRVKSVDLHPTEPWMLASL-YNGSVCVWNHETQTL 49 >4BTS-AR nrPDB Length = 343 Score = 158 bits (399), Expect = 5e-39, Method: Composition-based stats. Identities = 58/256 (22%), Positives = 103/256 (40%), Gaps = 36/256 (14%) Query: 177 LRGHQKEGYGLS--WNPNLN---GYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHT 231 L GH + ++ N L+S S D T+ +W + + TGH Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHN 76 Query: 232 AVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEF 291 V D+A + S + D+ L +WD R T K H +EV ++F+P + Sbjct: 77 HFVSDLALSQENCFAI-SSSWDKTLRLWDLRTGTTYKR---FVGHQSEVYSVAFSPDNRQ 132 Query: 292 ILATGSADKTVALWDLRN-LKLKLHSFESHKDEIFQVQWSPHNET---------ILASSG 341 IL + A++ + LW++ K E+H D + V++SP ++ AS G Sbjct: 133 IL-SAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVG 191 Query: 342 TDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDN 401 D RL VW+ + ++ + H + ++ S +PN + I + +D Sbjct: 192 WDGRLKVWNTN---------------FQIRYTFKAHESNVNHLSISPNGKY-IATGGKDK 235 Query: 402 IMQVWQMAENVYNDEE 417 + +W + Y E Sbjct: 236 KLLIWDILNLTYPQRE 251 Score = 151 bits (382), Expect = 5e-37, Method: Composition-based stats. Identities = 53/299 (17%), Positives = 120/299 (40%), Gaps = 46/299 (15%) Query: 126 NHEGEVNRA-----RYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGH 180 H V + +++ V+ + + V+++ + + + P L GH Sbjct: 19 GHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYE---EEQNGYFGIPHKALTGH 75 Query: 181 QKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH 240 L+ + N + +S+S D T+ LWD+ F GH + V VA+ Sbjct: 76 NHFVSDLALS-QENCFAISSSWDKTLRLWDLRTG-------TTYKRFVGHQSEVYSVAFS 127 Query: 241 LLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSE---------F 291 + + S ++++ +W+ S + H+ V+C+ ++P + Sbjct: 128 PDNRQIL-SAGAEREIKLWNIL-GECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAP 185 Query: 292 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 A+ D + +W+ ++F++H+ + + SP+ + I A+ G D++L +WD+ Sbjct: 186 YFASVGWDGRLKVWN--TNFQIRYTFKAHESNVNHLSISPNGKYI-ATGGKDKKLLIWDI 242 Query: 352 SKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 410 + Q DA + I+ ++NP W+ +V D ++++ + Sbjct: 243 LNLTYPQREFDAG--------------STINQIAFNPKLQWV--AVGTDQGVKIFNLMT 285 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 67/309 (21%), Positives = 124/309 (40%), Gaps = 41/309 (13%) Query: 105 EKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSK 164 E+ + G FG + H V+ + Q C + + + ++D + Sbjct: 58 EEEQNGYFGIPHKALT-----GHNHFVSDLA-LSQENCFAISSSWDKTLRLWDLRTGTT- 110 Query: 165 PEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAK 224 R GHQ E Y ++++P+ N +LSA + I LW+I + Sbjct: 111 ---------YKRFVGHQSEVYSVAFSPD-NRQILSAGAEREIKLWNI-----LGECKFSS 155 Query: 225 NIFTGHTAVVEDVAWHLLHES---------LFGSVADDQKLMIWDTRNNNTSKPSHTVDA 275 H+ V V + + +S F SV D +L +W+T + +T A Sbjct: 156 AEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNTNF----QIRYTFKA 211 Query: 276 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET 335 H + VN LS +P ++I ATG DK + +WD+ NL F++ I Q+ ++P + Sbjct: 212 HESNVNHLSISPNGKYI-ATGGKDKKLLIWDILNLTYPQREFDA-GSTINQIAFNPKLQW 269 Query: 336 ILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIIC 395 + + GTD+ + +++L + E P G + + +WN + Sbjct: 270 V--AVGTDQGVKIFNLMTQSKA-PVCTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFA 326 Query: 396 SVSEDNIMQ 404 D +++ Sbjct: 327 -GFTDGVIR 334 >6N9G-C nrPDB Length = 353 Score = 158 bits (399), Expect = 5e-39, Method: Composition-based stats. Identities = 67/279 (24%), Positives = 112/279 (40%), Gaps = 35/279 (12%) Query: 130 EVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW 189 V Y P C IA + V+ T ++ + + + H S+ Sbjct: 107 WVMACAYAPS-GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAM----HTNYLSACSF 161 Query: 190 NPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHE-SLFG 248 N + +L+AS D T LWD+ + F GH A V + + F Sbjct: 162 -TNSDMQILTASGDGTCALWDVESGQ-------LLQSFHGHGADVLCLDLAPSETGNTFV 213 Query: 249 SVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 308 S D+K M+WD R+ + + H ++VN + + P + A+GS D T L+DLR Sbjct: 214 SGGCDKKAMVWDMRS---GQCVQAFETHESDVNSVRYYPSGD-AFASGSDDATCRLYDLR 269 Query: 309 -NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGP 367 + ++ ++S ES V +S + A D ++VWD+ K Sbjct: 270 ADREVAIYSKESIIFGASSVDFSLSGRLLFAGY-NDYTINVWDVLKGSR----------- 317 Query: 368 PELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 + I GH ++S +P+ CS S D+ ++VW Sbjct: 318 ---VSILFGHENRVSTLRVSPDGT-AFCSGSWDHTLRVW 352 Score = 89.1 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 48/255 (18%), Positives = 86/255 (33%), Gaps = 71/255 (27%) Query: 207 CLWDINATPKEHRV-------IDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIW 259 L D+ RV + + GH V + W + S + D K+++W Sbjct: 32 KLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWC-KDKRRIVSSSQDGKVIVW 90 Query: 260 DT---------------------------------------------RNNNTSKPSHTVD 274 D+ +N N + +V Sbjct: 91 DSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVA 150 Query: 275 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHN- 333 HT ++ SF S+ + T S D T ALWD+ + +L L SF H ++ + +P Sbjct: 151 MHTNYLSACSFT-NSDMQILTASGDGTCALWDVESGQL-LQSFHGHGADVLCLDLAPSET 208 Query: 334 ETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWI 393 S G D++ VWD+ Q+ E H + ++ + P+ Sbjct: 209 GNTFVSGGCDKKAMVWDMRSGQCVQAFET--------------HESDVNSVRYYPSG-DA 253 Query: 394 ICSVSEDNIMQVWQM 408 S S+D +++ + Sbjct: 254 FASGSDDATCRLYDL 268 Score = 33.6 bits (75), Expect = 0.18, Method: Composition-based stats. Identities = 13/66 (19%), Positives = 23/66 (34%), Gaps = 1/66 (1%) Query: 345 RLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQ 404 R + D+ + E + GH K+ W ++ I+ S S+D + Sbjct: 30 RAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIV-SSSQDGKVI 88 Query: 405 VWQMAE 410 VW Sbjct: 89 VWDSFT 94 >5A9Q-0 nrPDB Length = 380 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 114/297 (38%), Gaps = 31/297 (10%) Query: 97 FDGSHYDNEK--------GEFGGF---GSVCGKIEIEIKINHEGEVNRARYMPQNACVIA 145 F +DNE+ G+FG G G ++ I H G+V ++ Q V A Sbjct: 32 FATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQERIVAA 91 Query: 146 TKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY-GLSWNPNL-----NGYLLS 199 + T V + HP+ S Q H G S P N +++ Sbjct: 92 SSTGCVTVFL----HHPNNQTLSVNQQWTTAHY-HTGPGSPSYSSAPCTGVVCNNPEIVT 146 Query: 200 ASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIW 259 +D I L+ + R ID + T H A L +V +L IW Sbjct: 147 VGEDGRINLFRADHKEAV-RTIDNADSSTLH-------AVTFLRTPEILTVNSIGQLKIW 198 Query: 260 DTRN-NNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFE 318 D R N ++ ++C+ +P + ++ATG D +++WD+R + + + Sbjct: 199 DFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLK 258 Query: 319 SHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHG 375 +H+ E+++V + P N L + D L WD S E+S+ + G H Sbjct: 259 AHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSHS 315 Score = 76.0 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 49/301 (16%), Positives = 108/301 (35%), Gaps = 37/301 (12%) Query: 131 VNRARYMP------QNACVIATKTPSSD---VLVFDYTKHPSKPEPSG---ECQPDLRLR 178 +++ R+ P Q A AT + ++ + ++ + G + Q +R Sbjct: 13 ISKTRWRPLPPGSLQTAETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIR 72 Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLW-DINATPKEHRVIDAKNIFTGHTAVVEDV 237 H + L + S++ T+ L N T ++ + TG + Sbjct: 73 HH-GDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSS 131 Query: 238 AWHLL---HESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILA 294 A + +V +D ++ ++ + + T+D + + IL Sbjct: 132 APCTGVVCNNPEIVTVGEDGRINLF---RADHKEAVRTIDNADSSTLHAVTFLRTPEILT 188 Query: 295 TGSADKTVALWDLRNLK---LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 S + +WD R ++ S + + V P+ + ++A+ G D L +WD+ Sbjct: 189 VNSI-GQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDV 247 Query: 352 SKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 + S A H A++ + ++P+ P + + SED + W + + Sbjct: 248 RQGTMPVSLLKA-------------HEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTD 294 Query: 412 V 412 V Sbjct: 295 V 295 >3JAP-g nrPDB Length = 326 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 57/305 (18%), Positives = 117/305 (38%), Gaps = 47/305 (15%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H G V ++ + + ++ + T++ + P +GH Sbjct: 16 GHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGV-----PVRSYKGHSHIVQ 70 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 + + + Y +SAS D T+ LW++ E R F GHT V VA Sbjct: 71 DVVVSAD-GNYAVSASWDKTLRLWNLATGNSEAR-------FVGHTGDVLSVAIDANSSK 122 Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP---------YSEFILATG 296 + S + D+ + +W+T ++ + HT V + P + Sbjct: 123 II-SASRDKTIRVWNT----VGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSA 177 Query: 297 SADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIG 355 DK V W L ++ F H + I VQ SP ++ AS+G D +++VW+L Sbjct: 178 GMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDG-SLAASAGKDGQIYVWNLK--- 233 Query: 356 EEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM-AENVYN 414 + F++ ++ +++P+ W+ + + ++++ + E + + Sbjct: 234 ------------HKSAFMNFDAKDEVFALAFSPSRFWLTAATASG--IKIYDLENEVLID 279 Query: 415 DEEPE 419 + +PE Sbjct: 280 ELKPE 284 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 49/245 (20%), Positives = 92/245 (37%), Gaps = 31/245 (12%) Query: 176 RLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVE 235 L GH LS + L+S S D T+ W + ++ V + GH+ +V+ Sbjct: 13 TLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGV--PVRSYKGHSHIVQ 70 Query: 236 DVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILAT 295 DV S + D+ L +W+ N+ HT +V ++ + S I+ + Sbjct: 71 DVVVSADGNYAV-SASWDKTLRLWNLATGNS---EARFVGHTGDVLSVAIDANSSKII-S 125 Query: 296 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP---------HNETILASSGTDRRL 346 S DKT+ +W+ + + H D + +V+ +P S+G D+ + Sbjct: 126 ASRDKTIRVWN--TVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIV 183 Query: 347 HVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 W L++ + GH I+ +P+ + S +D + VW Sbjct: 184 RSWSLNEDSYR------------IEADFIGHNNYINVVQPSPDGS-LAASAGKDGQIYVW 230 Query: 407 QMAEN 411 + Sbjct: 231 NLKHK 235 Score = 108 bits (269), Expect = 5e-24, Method: Composition-based stats. Identities = 37/201 (18%), Positives = 73/201 (36%), Gaps = 29/201 (14%) Query: 224 KNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNN--NTSKPSHTVDAHTAEVN 281 + GH V ++ +L S + D+ L+ W N P + H+ V Sbjct: 11 RGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQ 70 Query: 282 CLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG 341 + + + + + S DKT+ LW+L + F H ++ V ++ I+ S+ Sbjct: 71 DVVVSADGNYAV-SASWDKTLRLWNLATGNSEAR-FVGHTGDVLSVAIDANSSKII-SAS 127 Query: 342 TDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNP---------NEPW 392 D+ + VW+ + ++ GHT ++ P + Sbjct: 128 RDKTIRVWNT---------------VGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRI 172 Query: 393 IICSVSEDNIMQVWQMAENVY 413 S D I++ W + E+ Y Sbjct: 173 TFVSAGMDKIVRSWSLNEDSY 193 >5YZG-W nrPDB Length = 579 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 51/228 (22%), Positives = 91/228 (39%), Gaps = 28/228 (12%) Query: 178 RGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDV 237 GH K + P LLS S D I LW++ + F GH+ V D+ Sbjct: 285 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERR------CLRTFIGHSKAVRDI 338 Query: 238 AWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP--YSEFILAT 295 ++ F S A D+ L +WDT T + C+ FNP + + Sbjct: 339 CFNTAGTQ-FLSAAYDRYLKLWDTE---TGQCISRFTNRKVP-YCVKFNPDEDKQNLFVA 393 Query: 296 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIG 355 G +DK + WD+R+ ++ + ++ H + + + N +++S D+ L VW+ Sbjct: 394 GMSDKKIVQWDIRSGEI-VQEYDRHLGAVNTIVFVDENRRFVSTSD-DKSLRVWEW---- 447 Query: 356 EEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIM 403 D P + +I + + +PN W+ C ++ I+ Sbjct: 448 ---------DIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQIL 486 Score = 121 bits (304), Expect = 5e-28, Method: Composition-based stats. Identities = 63/382 (16%), Positives = 123/382 (32%), Gaps = 93/382 (24%) Query: 75 HTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRA 134 H + ++ + + +P + S EK K +I + H V+ Sbjct: 242 HVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYL-------PKKQIHVWSGHTKGVSAV 294 Query: 135 RYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLN 194 R P + ++ + + + +++ GE + GH K + +N Sbjct: 295 RLFPLSGHLLLSCSMDCKIKLWEVY---------GERRCLRTFIGHSKAVRDICFNT-AG 344 Query: 195 GYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHE--SLFGSVAD 252 LSA+ D + LWD R + V V ++ + +LF + Sbjct: 345 TQFLSAAYDRYLKLWDTETGQCISRFTN--------RKVPYCVKFNPDEDKQNLFVAGMS 396 Query: 253 DQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL----- 307 D+K++ WD R+ + D H VN + F + ++T S DK++ +W+ Sbjct: 397 DKKIVQWDIRS---GEIVQEYDRHLGAVNTIVFVDENRRFVST-SDDKSLRVWEWDIPVD 452 Query: 308 -------------------RNLKLKLHS---------------------FESH--KDEIF 325 L S F+ H Sbjct: 453 FKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYAC 512 Query: 326 QVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFS 385 QV +SP ++ S + +L++WD +L H Sbjct: 513 QVDFSPDMSYVI-SGDGNGKLNIWDWKTT--------------KLYSRFKAHDKVCIGAV 557 Query: 386 WNPNEPWIICSVSEDNIMQVWQ 407 W+P+E + + D ++++W Sbjct: 558 WHPHETSKVITCGWDGLIKLWD 579 Score = 89.5 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 28/145 (19%), Positives = 53/145 (36%), Gaps = 14/145 (9%) Query: 267 SKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQ 326 K H HT V+ + P S +L + S D + LW++ + L +F H + Sbjct: 278 KKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRD 337 Query: 327 VQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSW 386 + ++ L S+ DR L +WD ++ G+ S P + F Sbjct: 338 ICFNTAGTQFL-SAAYDRYLKLWD-TETGQCISRFTNRKVPYCVKFNPDE---------- 385 Query: 387 NPNEPWIICSVSEDNIMQVWQMAEN 411 ++ + + D + W + Sbjct: 386 --DKQNLFVAGMSDKKIVQWDIRSG 408 Score = 34.4 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 10/43 (23%), Positives = 21/43 (48%) Query: 367 PPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMA 409 P + + + GHT +S P ++ S S D +++W++ Sbjct: 277 PKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVY 319 >6QDV-o nrPDB Length = 513 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 51/228 (22%), Positives = 91/228 (39%), Gaps = 28/228 (12%) Query: 178 RGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDV 237 GH K + P LLS S D I LW++ + F GH+ V D+ Sbjct: 219 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERR------CLRTFIGHSKAVRDI 272 Query: 238 AWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP--YSEFILAT 295 ++ F S A D+ L +WDT T + C+ FNP + + Sbjct: 273 CFNTAGTQ-FLSAAYDRYLKLWDTE---TGQCISRFTNRKVP-YCVKFNPDEDKQNLFVA 327 Query: 296 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIG 355 G +DK + WD+R+ ++ + ++ H + + + N +++S D+ L VW+ Sbjct: 328 GMSDKKIVQWDIRSGEI-VQEYDRHLGAVNTIVFVDENRRFVSTSD-DKSLRVWEW---- 381 Query: 356 EEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIM 403 D P + +I + + +PN W+ C ++ I+ Sbjct: 382 ---------DIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQIL 420 Score = 121 bits (304), Expect = 5e-28, Method: Composition-based stats. Identities = 63/382 (16%), Positives = 123/382 (32%), Gaps = 93/382 (24%) Query: 75 HTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRA 134 H + ++ + + +P + S EK K +I + H V+ Sbjct: 176 HVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYL-------PKKQIHVWSGHTKGVSAV 228 Query: 135 RYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLN 194 R P + ++ + + + +++ GE + GH K + +N Sbjct: 229 RLFPLSGHLLLSCSMDCKIKLWEVY---------GERRCLRTFIGHSKAVRDICFNT-AG 278 Query: 195 GYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHE--SLFGSVAD 252 LSA+ D + LWD R + V V ++ + +LF + Sbjct: 279 TQFLSAAYDRYLKLWDTETGQCISRFTN--------RKVPYCVKFNPDEDKQNLFVAGMS 330 Query: 253 DQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL----- 307 D+K++ WD R+ + D H VN + F + ++T S DK++ +W+ Sbjct: 331 DKKIVQWDIRS---GEIVQEYDRHLGAVNTIVFVDENRRFVST-SDDKSLRVWEWDIPVD 386 Query: 308 -------------------RNLKLKLHS---------------------FESH--KDEIF 325 L S F+ H Sbjct: 387 FKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYAC 446 Query: 326 QVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFS 385 QV +SP ++ S + +L++WD +L H Sbjct: 447 QVDFSPDMSYVI-SGDGNGKLNIWDWKTT--------------KLYSRFKAHDKVCIGAV 491 Query: 386 WNPNEPWIICSVSEDNIMQVWQ 407 W+P+E + + D ++++W Sbjct: 492 WHPHETSKVITCGWDGLIKLWD 513 Score = 89.5 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 28/145 (19%), Positives = 53/145 (36%), Gaps = 14/145 (9%) Query: 267 SKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQ 326 K H HT V+ + P S +L + S D + LW++ + L +F H + Sbjct: 212 KKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRD 271 Query: 327 VQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSW 386 + ++ L S+ DR L +WD ++ G+ S P + F Sbjct: 272 ICFNTAGTQFL-SAAYDRYLKLWD-TETGQCISRFTNRKVPYCVKFNPDE---------- 319 Query: 387 NPNEPWIICSVSEDNIMQVWQMAEN 411 ++ + + D + W + Sbjct: 320 --DKQNLFVAGMSDKKIVQWDIRSG 342 Score = 34.4 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 10/43 (23%), Positives = 21/43 (48%) Query: 367 PPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMA 409 P + + + GHT +S P ++ S S D +++W++ Sbjct: 211 PKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVY 253 >3JRP-A nrPDB Length = 379 Score = 154 bits (390), Expect = 4e-38, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 108/295 (36%), Gaps = 47/295 (15%) Query: 144 IATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW-NPNLNGYLLSASD 202 +AT + + +F+ K + L GH+ + + W +P L S S Sbjct: 26 LATCSSDKTIKIFEVEGETHKLIDT--------LTGHEGPVWRVDWAHPKFGTILASCSY 77 Query: 203 DHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLH-ESLFGSVADDQKLMIWDT 261 D + +W +E+ + H+A V V W L + D K+ + + Sbjct: 78 DGKVLIW-----KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEF 132 Query: 262 RNNNTSKPSHTVDAHTAEVNCLSFNP------------YSEFILATGSADKTVALWDLRN 309 + N T+ P +DAH VN S+ P TG AD V +W + Sbjct: 133 KENGTTSPI-IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNS 191 Query: 310 LKLKL---HSFESHKDEIFQVQWSPHN--ETILASSGTDRRLHVWDLSKIGEEQSTEDAE 364 + E H D + V WSP + LAS DR +W T+D E Sbjct: 192 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW----------TQDNE 241 Query: 365 DGPPELLFIHGGHTAKI-SDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEP 418 GP + + + SW+ + + S DN + +W+ EN+ EP Sbjct: 242 QGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGG-DNKVTLWK--ENLEGKWEP 293 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 50/250 (20%), Positives = 88/250 (35%), Gaps = 35/250 (14%) Query: 121 IEIKINHEGEVNRARY-MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRG 179 I+ HEG V R + P+ ++A+ + VL++ E +G Sbjct: 48 IDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK--------EENGRWSQIAVHAV 99 Query: 180 HQKEGYGLSWNPNL-NGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 H + W P+ LL AS D + + + +I H V + Sbjct: 100 HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII-----IDAHAIGVNSAS 154 Query: 239 WHL------------LHESLFGSVADDQKLMIWDT-RNNNTSKPSHTVDAHTAEVNCLSF 285 W F + D + IW + T T++ H+ V +++ Sbjct: 155 WAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAW 214 Query: 286 NPY--SEFILATGSADKTVALW--DLRNLKLKLHSFESHKDE--IFQVQWSPHNETILAS 339 +P LA+ S D+T +W D K + K +++ WS +LA Sbjct: 215 SPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSG-NVLAL 273 Query: 340 SGTDRRLHVW 349 SG D ++ +W Sbjct: 274 SGGDNKVTLW 283 >4N14-A nrPDB Length = 314 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 50/259 (19%), Positives = 95/259 (36%), Gaps = 26/259 (10%) Query: 106 KGEFGGFGSVCGKIEI------EIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYT 159 +G + G+ ++++ + N R + N+ ++++ + S + D Sbjct: 74 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVR 133 Query: 160 KHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHR 219 L GH +E GL W P+ +L S +D+ + +W Sbjct: 134 VAE---------HHVATLSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWPSAPGEGG-- 181 Query: 220 VIDAKNIFTGHTAVVEDVAWHLLHESLFGSVA--DDQKLMIWDTRNNNTSKPSHTVDAHT 277 FT H V+ VAW ++ + D+ + IW+ + VDAH+ Sbjct: 182 -WVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV---CSGACLSAVDAHS 237 Query: 278 AEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL 337 + L Y E I G A + +W + K+ + H + + SP T+ Sbjct: 238 QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA-KVAELKGHTSRVLSLTMSPDGATV- 295 Query: 338 ASSGTDRRLHVWDLSKIGE 356 AS+ D L +W ++ Sbjct: 296 ASAAADETLRLWRCFELDP 314 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 51/289 (17%), Positives = 109/289 (37%), Gaps = 33/289 (11%) Query: 128 EGEVNRARYMPQNACVIATKTP--SSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 G++ + M Q I++ + L + + + + + H Sbjct: 50 SGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVG 109 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 LSWN + L S S I D+ +GH+ V + W Sbjct: 110 SLSWN---SYILSSGSRSGHIHHHDVRVAE------HHVATLSGHSQEVCGLRWAPDGRH 160 Query: 246 LFGSVADDQKLMIWDTRNNNTS-KPSHTVDAHTAEVNCLSFNPYSEFILATGS--ADKTV 302 L S +D + +W + P T H V +++ P+ +LATG +D+ + Sbjct: 161 L-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHI 219 Query: 303 ALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG-TDRRLHVWDLSKIGEEQSTE 361 +W++ + L + ++H + + WSPH + +++ G +L +W + + Sbjct: 220 RIWNVCSGAC-LSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAK----- 272 Query: 362 DAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 410 + GHT+++ + +P+ + S + D +++W+ E Sbjct: 273 ---------VAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLWRCFE 311 Score = 99.1 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 43/227 (18%), Positives = 90/227 (39%), Gaps = 28/227 (12%) Query: 187 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 246 + W+ +G +L+ + D+++ LW ++ I + VAW + + Sbjct: 27 VDWS---SGNVLAVALDNSVYLWSASSGD-----ILQLLQMEQPGEYISSVAW-IKEGNY 77 Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 ++ +WD + K + +H+A V LS+N +IL++GS + D Sbjct: 78 LAVGTSSAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHD 131 Query: 307 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 366 +R + + + H E+ ++W+P LAS G D ++VW +G Sbjct: 132 VRVAEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW----------PSAPGEG 180 Query: 367 PPELLFIHGGHTAKISDFSWNPNEPWIICSVS--EDNIMQVWQMAEN 411 L H + +W P + ++ + D +++W + Sbjct: 181 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG 227 >4YCZ-A nrPDB Length = 876 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 62/331 (18%), Positives = 121/331 (36%), Gaps = 54/331 (16%) Query: 111 GFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGE 170 G GS+ ++ H+ ++ + +AT + + +F+ + + Sbjct: 1 GPGSMAAGTQVIANSGHDDMIHD-AVLDYYGRRLATCSSDRTIKIFEIEGETQRLTET-- 57 Query: 171 CQPDLRLRGHQKEGYGLSW-NPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTG 229 L+GH + +SW +P L SA D + +W + + F Sbjct: 58 ------LKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIW-----RELNGAWQRIFDFAL 106 Query: 230 HTAVVEDVAWHLLHES-LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPY 288 H A V V+W L + D + + + R+N+ AH VN +S+ P Sbjct: 107 HKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEH--SIFHAHGLGVNSVSWAPA 164 Query: 289 SEF----------------ILATGSADKTVALW--D--LRNLKLKLHSFESHKDEIFQVQ 328 + TG +D + +W D KL+ H D + V Sbjct: 165 TSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVA 224 Query: 329 WSPHN--ETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSW 386 WSP ++ +AS+ DR + +W +++ A ++ A + SW Sbjct: 225 WSPTVLQKSYIASASEDRTVRIW---------TSDPANPLQWNCKVLNF--DAAVWRVSW 273 Query: 387 NPNEPWIICSVSEDNIMQVWQMAENVYNDEE 417 + + ++ + DN + +W+ EN+ + E Sbjct: 274 SLSG-NVLAASGGDNKVTLWK--ENLKGEWE 301 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 59/267 (22%), Positives = 104/267 (38%), Gaps = 45/267 (16%) Query: 126 NHEGEVNRARY-MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEG 184 H+G V + P+ ++A+ VL++ E +G Q H+ Sbjct: 60 GHDGAVWCVSWAHPKYGNILASAGYDGKVLIWR--------ELNGAWQRIFDFALHKASV 111 Query: 185 YGLSWNPNLNG-YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHL-- 241 +SW+P+ G L AS D + + + EH + F H V V+W Sbjct: 112 NVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHSI------FHAHGLGVNSVSWAPAT 165 Query: 242 --------------LHESLFGSVADDQKLMIW--DTRNNNTSKPSHTVDAHTAEVNCLSF 285 F + D L IW D N + HT V +++ Sbjct: 166 SPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAW 225 Query: 286 NPY--SEFILATGSADKTVALW--DLRNL---KLKLHSFESHKDEIFQVQWSPHNETILA 338 +P + +A+ S D+TV +W D N K+ +F++ +++V WS +LA Sbjct: 226 SPTVLQKSYIASASEDRTVRIWTSDPANPLQWNCKVLNFDA---AVWRVSWSLSG-NVLA 281 Query: 339 SSGTDRRLHVWDLSKIGEEQSTEDAED 365 +SG D ++ +W + GE + + E+ Sbjct: 282 ASGGDNKVTLWKENLKGEWECVKTIEE 308 >5OQL-J nrPDB Length = 912 Score = 150 bits (379), Expect = 9e-37, Method: Composition-based stats. Identities = 63/350 (18%), Positives = 130/350 (37%), Gaps = 61/350 (17%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQP-------DLRLR 178 E+ Y+ + ++A T S D+ + + E + EC+ L+ Sbjct: 371 GTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLK 430 Query: 179 GHQKEGYG--LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 GH+ + W+ ++ S S D+T LW ++ + +FTGH V Sbjct: 431 GHEDIVMSLDVDWS---GHWIASGSKDNTARLWRVDPANNSY---TCYAVFTGHLESVGA 484 Query: 237 VAW-------------HLLH--ESLFGSVADDQKLMIWDTR--NNNTSKPSHTVD--AHT 277 VA + L + S + D+ + D K + ++ AH Sbjct: 485 VALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHD 544 Query: 278 AEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP------ 331 ++N L +P + + A+ S DKTV +WD+ L+++ HK ++ V+++P Sbjct: 545 KDINALDISPNGK-LFASASQDKTVKIWDVEKLEVQG-ILRGHKRGVWTVRFAPLNTPVI 602 Query: 332 -------HNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDF 384 ++ + D+ + +W+LS ++ E +++++H I+ Sbjct: 603 QGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITK- 661 Query: 385 SWNPNEPWIICSVSEDNIMQVWQMAEN------VYNDEEPEIPASELETN 428 S D +++VW +++ A +TN Sbjct: 662 -----TKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTN 706 Score = 139 bits (351), Expect = 2e-33, Method: Composition-based stats. Identities = 68/370 (18%), Positives = 131/370 (35%), Gaps = 64/370 (17%) Query: 74 THTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNR 133 T+ +Q+ + IA+ + +E GS G ++ + HE V Sbjct: 380 TYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFG-HDVALLKGHEDIVMS 438 Query: 134 ARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW---- 189 + + IA+ + + ++ + S C GH + ++ Sbjct: 439 LD-VDWSGHWIASGSKDNTARLWRVDPANN----SYTCY--AVFTGHLESVGAVALPKVV 491 Query: 190 ---------NP--NLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 NP + +L+S S D + DI ++ + + H + + Sbjct: 492 PPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALD 551 Query: 239 WHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI------ 292 + LF S + D+ + IWD + + H V + F P + + Sbjct: 552 ISPNGK-LFASASQDKTVKIWDVEK---LEVQGILRGHKRGVWTVRFAPLNTPVIQGEQG 607 Query: 293 -------LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQW---SPHNE-----TIL 337 + TGS DKT+ LW+L + + +FE H + +V W S + Sbjct: 608 SVSGRGVVLTGSGDKTIKLWNLSDYTC-IRTFEGHSHNVLKVVWLHISRDDSITKTKVQF 666 Query: 338 ASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSV 397 AS+G D + VWD + GE + T D H ++ + + ++ I+ S Sbjct: 667 ASAGADTLVKVWD-ANTGETECTLDN-------------HEDRLWTLAVH-SKTNILASA 711 Query: 398 SEDNIMQVWQ 407 D+ + W+ Sbjct: 712 GSDSKVTFWR 721 Score = 83.3 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 53/305 (17%), Positives = 105/305 (34%), Gaps = 45/305 (14%) Query: 130 EVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW 189 ++ P + +I + S + ++ P S E + H L+ Sbjct: 63 PISTLTITPSGSHLIV-CSRSLTMRIYSLAISPDY--DSVEPTLVRTTKPHATPVVVLAV 119 Query: 190 NPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFT--------------------- 228 + + L + + D I +WDI H V + + Sbjct: 120 DR-TSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPK 178 Query: 229 -GHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTS----KPSHTVDAHTAEVNCL 283 G D A + D ++ I+D T+ P +AH + V C+ Sbjct: 179 KGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCI 238 Query: 284 SFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTD 343 +++P +L +GS DKT+ LW R+ + H+ + V + + + S+GT Sbjct: 239 AYSPEQHALL-SGSRDKTMTLWLWRDGIWQGTPMLRHE-LLESVGFLNEGKWMY-SAGTS 295 Query: 344 RRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIM 403 L +WD + E +DA+ +L + + E +I D + Sbjct: 296 GVLRIWDTTTHHEITKKQDAKSEGEAILS------------AVSLPERSLILCAQADFTL 343 Query: 404 QVWQM 408 ++++ Sbjct: 344 VLYRV 348 Score = 71.0 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 54/344 (15%), Positives = 105/344 (30%), Gaps = 84/344 (24%) Query: 143 VIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNG------- 195 ++AT + ++D SG L H E + + + N Sbjct: 125 LLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSAL--HFFEIAVTAESQSSNKKPKKGSR 182 Query: 196 --------------YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHL 241 L + D I ++D+ D K H + V+ +A+ Sbjct: 183 KGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSP 242 Query: 242 LHESLFGSVADDQK------------------------------------------LMIW 259 +L S + D+ L IW Sbjct: 243 EQHALL-SGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGFLNEGKWMYSAGTSGVLRIW 301 Query: 260 DTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES 319 DT ++ + + P IL AD T+ L+ + + + S E Sbjct: 302 DTTTHHEITKKQDAKSEGEAILSAVSLPERSLILC-AQADFTLVLYRVPSPADVVSSSEG 360 Query: 320 ------------HKDEIFQVQWSPHNETI--LASSGTD-RRLHVWDLSKIGEEQSTEDAE 364 H DEI + + ++++ +A++ D R + V D E+ + + Sbjct: 361 ILLEPFRRISGTH-DEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSG 419 Query: 365 DGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 + + GH + + + W I S S+DN ++W++ Sbjct: 420 SYFGHDVALLKGHEDIVMSLDVDWSGHW-IASGSKDNTARLWRV 462 Score = 60.2 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 34/222 (15%), Positives = 70/222 (31%), Gaps = 45/222 (20%) Query: 228 TGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDT---RNNNTSKPS--HTVDAHTAEVNC 282 G + + L + + I+ + ++ +P+ T H V Sbjct: 58 QGDGEPISTLTITPSGSHLIV-CSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVV 116 Query: 283 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQW------------- 329 L+ + S +LATG+AD + +WD+ H+ + + + Sbjct: 117 LAVDRTST-LLATGAADGAIKIWDI-IGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSN 174 Query: 330 ----------SPHNETILAS------SGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFI 373 + +AS D R+ ++DL K D Sbjct: 175 KKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYAD-------PKRK 227 Query: 374 HGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYND 415 H + + +++P E + S S D M +W + ++ Sbjct: 228 KEAHESNVQCIAYSP-EQHALLSGSRDKTMTLWLWRDGIWQG 268 >4BZK-B nrPDB Length = 297 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 108/295 (36%), Gaps = 47/295 (15%) Query: 144 IATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW-NPNLNGYLLSASD 202 +AT + + +F+ K + L GH+ + + W +P L S S Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDT--------LTGHEGPVWRVDWAHPKFGTILASCSY 75 Query: 203 DHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLH-ESLFGSVADDQKLMIWDT 261 D + +W +E+ + H+A V V W L + D K+ + + Sbjct: 76 DGKVLIW-----KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEF 130 Query: 262 RNNNTSKPSHTVDAHTAEVNCLSFNP------------YSEFILATGSADKTVALWDLRN 309 + N T+ P +DAH VN S+ P TG AD V +W + Sbjct: 131 KENGTTSPI-IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNS 189 Query: 310 LKLKL---HSFESHKDEIFQVQWSPHN--ETILASSGTDRRLHVWDLSKIGEEQSTEDAE 364 + E H D + V WSP + LAS DR +W T+D E Sbjct: 190 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW----------TQDNE 239 Query: 365 DGPPELLFIHGGHTAKI-SDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEP 418 GP + + + SW+ + + S DN + +W+ EN+ EP Sbjct: 240 QGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGG-DNKVTLWK--ENLEGKWEP 291 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 50/250 (20%), Positives = 88/250 (35%), Gaps = 35/250 (14%) Query: 121 IEIKINHEGEVNRARY-MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRG 179 I+ HEG V R + P+ ++A+ + VL++ E +G Sbjct: 46 IDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK--------EENGRWSQIAVHAV 97 Query: 180 HQKEGYGLSWNPNL-NGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 H + W P+ LL AS D + + + +I H V + Sbjct: 98 HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII-----IDAHAIGVNSAS 152 Query: 239 WHL------------LHESLFGSVADDQKLMIWDT-RNNNTSKPSHTVDAHTAEVNCLSF 285 W F + D + IW + T T++ H+ V +++ Sbjct: 153 WAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAW 212 Query: 286 NPY--SEFILATGSADKTVALW--DLRNLKLKLHSFESHKDE--IFQVQWSPHNETILAS 339 +P LA+ S D+T +W D K + K +++ WS +LA Sbjct: 213 SPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSG-NVLAL 271 Query: 340 SGTDRRLHVW 349 SG D ++ +W Sbjct: 272 SGGDNKVTLW 281 >3MKQ-A nrPDB Length = 814 Score = 148 bits (374), Expect = 3e-36, Method: Composition-based stats. Identities = 52/274 (18%), Positives = 99/274 (36%), Gaps = 26/274 (9%) Query: 128 EGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGL 187 E V +++ + +I + + VF+Y + + H + Sbjct: 55 ETPVRAGKFIARKNWIIV-GSDDFRIRVFNYN----------TGEKVVDFEAHPDYIRSI 103 Query: 188 SWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLF 247 + +P Y+LS SDD T+ LW+ + F GH V VA++ S F Sbjct: 104 AVHPTK-PYVLSGSDDLTVKLWNWENN------WALEQTFEGHEHFVMCVAFNPKDPSTF 156 Query: 248 GSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPY-SEFILATGSADKTVALWD 306 S D+ + +W + + T VN + + P + + T S D T+ +WD Sbjct: 157 ASGCLDRTVKVWSLGQSTPNFTLTT--GQERGVNYVDYYPLPDKPYMITASDDLTIKIWD 214 Query: 307 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 366 + + + E H + + P I+ S D L +W+ S E++ + Sbjct: 215 YQTKSC-VATLEGHMSNVSFAVFHPTLP-IIISGSEDGTLKIWNSSTYKVEKTLNVGLER 272 Query: 367 PPELLFIHGGHTAKISDFSWNPNEPWIICSVSED 400 + G I+ + + + S+ D Sbjct: 273 SWCIATHPTGRKNYIAS---GFDNGFTVLSLGND 303 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 45/272 (16%), Positives = 99/272 (36%), Gaps = 45/272 (16%) Query: 170 ECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTG 229 + G+ ++P ++L+ + +W+ + + + Sbjct: 2 KLDIKKTFSNRSDRVKGIDFHP-TEPWVLTTLYSGRVEIWNYETQVEVRSIQVTET---- 56 Query: 230 HTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS 289 V + + ++ +DD ++ +++ NT + +AH + ++ +P Sbjct: 57 ---PVRAGKF-IARKNWIIVGSDDFRIRVFN---YNTGEKVVDFEAHPDYIRSIAVHPTK 109 Query: 290 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 ++L +GS D TV LW+ N +FE H+ + V ++P + + AS DR + VW Sbjct: 110 PYVL-SGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVW 168 Query: 350 DLSKIGEEQSTEDAED-------------------------------GPPELLFIHGGHT 378 L + + ++ + GH Sbjct: 169 SLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHM 228 Query: 379 AKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 410 + +S ++P P II S SED +++W + Sbjct: 229 SNVSFAVFHPTLP-IIISGSEDGTLKIWNSST 259 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 41/245 (16%), Positives = 82/245 (33%), Gaps = 22/245 (8%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H + P V+ + + V ++++ + GH+ Sbjct: 95 AHPDYIRSIAVHPTKPYVL-SGSDDLTVKLWNWE---------NNWALEQTFEGHEHFVM 144 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHL-LHE 244 +++NP S D T+ +W + + + TG V V ++ + Sbjct: 145 CVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLT------TGQERGVNYVDYYPLPDK 198 Query: 245 SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 304 + +DD + IWD T T++ H + V+ F+P I+ +GS D T+ + Sbjct: 199 PYMITASDDLTIKIWD---YQTKSCVATLEGHMSNVSFAVFHPTLPIII-SGSEDGTLKI 254 Query: 305 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAE 364 W+ K++ + + + P +SG D V L S + Sbjct: 255 WNSSTYKVEKTLNVGLERS-WCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDPVG 313 Query: 365 DGPPE 369 Sbjct: 314 KLVWS 318 Score = 102 bits (253), Expect = 4e-22, Method: Composition-based stats. Identities = 55/297 (18%), Positives = 104/297 (35%), Gaps = 36/297 (12%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRL-RGHQKEG 184 HE V + P++ A+ V V+ G+ P+ L G ++ Sbjct: 138 GHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSL----------GQSTPNFTLTTGQERGV 187 Query: 185 YGLSWNPN-LNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLH 243 + + P Y+++ASDD TI +WD ++ GH + V +H Sbjct: 188 NYVDYYPLPDKPYMITASDDLTIKIWD-------YQTKSCVATLEGHMSNVSFAVFHPTL 240 Query: 244 ESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVA 303 + S ++D L IW+ ++T K T++ C++ +P D Sbjct: 241 P-IIISGSEDGTLKIWN---SSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFT 296 Query: 304 LWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDA 363 + L N + L D + ++ WS + AS + + + E S + Sbjct: 297 VLSLGNDEPTLSL-----DPVGKLVWS-GGKNAAASDIFTAVIRGNEEVEQDEPLSLQTK 350 Query: 364 EDGPPELLFIHGGHTAKISDFSWNPNEPWIICSV-SEDNIM------QVWQMAENVY 413 E G ++ H+ + + ++I + + N VW N Y Sbjct: 351 ELGSVDVFPQSLAHSPNGRFVTVVGDGEYVIYTALAWRNKAFGKCQDFVWGPDSNSY 407 Score = 94.9 bits (234), Expect = 7e-20, Method: Composition-based stats. Identities = 34/192 (17%), Positives = 71/192 (36%), Gaps = 20/192 (10%) Query: 221 IDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEV 280 +D K F+ + V+ + +H + ++ ++ IW+ + + V Sbjct: 3 LDIKKTFSNRSDRVKGIDFHPTEPWVLTTL-YSGRVEIWNYETQVEVRSIQVTET---PV 58 Query: 281 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 340 F +I+ GS D + +++ + K+ FE+H D I + P +L S Sbjct: 59 RAGKFIARKNWIIV-GSDDFRIRVFNYNTGE-KVVDFEAHPDYIRSIAVHPTKPYVL-SG 115 Query: 341 GTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSED 400 D + +W+ L GH + ++NP +P S D Sbjct: 116 SDDLTVKLWNWENN-------------WALEQTFEGHEHFVMCVAFNPKDPSTFASGCLD 162 Query: 401 NIMQVWQMAENV 412 ++VW + ++ Sbjct: 163 RTVKVWSLGQST 174 >2PM9-A nrPDB Length = 416 Score = 147 bits (371), Expect = 7e-36, Method: Composition-based stats. Identities = 57/303 (18%), Positives = 107/303 (35%), Gaps = 33/303 (10%) Query: 138 PQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYL 197 N +IA + + ++ E + R H + +N + L Sbjct: 76 SHNNKIIAGALDNGSLELYSTN------EANNAINSMARFSNHSSSVKTVKFNAKQDNVL 129 Query: 198 LSASDDHTICLWDINA---TPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQ 254 S ++ I +WD+N +P + + + V +AW+ +F S Sbjct: 130 ASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSS-VDEVISLAWNQSLAHVFASAGSSN 188 Query: 255 KLMIWDTRNNNTSKPSHTVD---AHTAEVNCLSFNPYSEFILATGSA---DKTVALWDLR 308 IWD + +++ + ++P + +AT + D ++ +WDLR Sbjct: 189 FASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLR 248 Query: 309 NLKLKLHSF-ESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGP 367 N L + + H+ I + W +E +L SSG D + +W+ Sbjct: 249 NANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPES-------------- 294 Query: 368 PELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQV--WQMAENVYNDEEPEIPASEL 425 E L + P P + S DN ++V Q N +++E E E Sbjct: 295 AEQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQNLTNTLDEQETETKQQES 354 Query: 426 ETN 428 ET+ Sbjct: 355 ETD 357 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 52/259 (20%), Positives = 104/259 (40%), Gaps = 9/259 (3%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 NH V ++ + V+A+ + ++ ++D K P P + E Sbjct: 111 NHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSS-VDEVI 169 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 L+WN +L SA + +WD+ A + + +G + V WH + + Sbjct: 170 SLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPN-SGIKQQLSVVEWHPKNST 228 Query: 246 LFGSVA---DDQKLMIWDTRNNNTSKPSHTVD-AHTAEVNCLSFNPYSEFILATGSADKT 301 + +D ++IWD RN NT P T++ H + L + E +L + D T Sbjct: 229 RVATATGSDNDPSILIWDLRNANT--PLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNT 286 Query: 302 VALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTE 361 V LW+ + + +L F + + F+ +++P + A + D ++ V L + + Sbjct: 287 VLLWNPESAE-QLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQNLTNTLDEQ 345 Query: 362 DAEDGPPELLFIHGGHTAK 380 + E E + ++ Sbjct: 346 ETETKQQESETDFWNNVSR 364 Score = 72.1 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 32/185 (17%), Positives = 71/185 (38%), Gaps = 20/185 (10%) Query: 238 AWHLLHESLFGSV----------ADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP 287 AW L S + D L +W ++ KP ++ + N L ++ Sbjct: 19 AWSHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKF-NDLDWSH 77 Query: 288 YSEFILATGSADKTVALWDLRNLKLKLHS---FESHKDEIFQVQWSPHNETILASSGTDR 344 ++ I+A + ++ L+ ++S F +H + V+++ + +LAS G + Sbjct: 78 NNK-IIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNG 136 Query: 345 RLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQ 404 + +WD++K E S + + ++ +WN + + S N Sbjct: 137 EIFIWDMNKCTESPSNYTPLTPGQSMSSV-----DEVISLAWNQSLAHVFASAGSSNFAS 191 Query: 405 VWQMA 409 +W + Sbjct: 192 IWDLK 196 >4L9O-A nrPDB Length = 349 Score = 147 bits (371), Expect = 8e-36, Method: Composition-based stats. Identities = 58/294 (19%), Positives = 111/294 (37%), Gaps = 43/294 (14%) Query: 144 IATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW-NPNLNGYLLSASD 202 +AT + + +F+ + L GH+ + ++W +P L S S Sbjct: 84 LATCSSDKTIKIFEI--------DGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSY 135 Query: 203 DHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLH-ESLFGSVADDQKLMIWDT 261 D + +W +++ V + + H A V V+W + + D K+ I + Sbjct: 136 DGKVLIW-----KEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEF 190 Query: 262 RNNNTSKPSHTVDAHTAEVNCLSFN----PYSEFILATGSADKTVALW---DLRNLKLKL 314 ++ +P + H VN S+ P + +G D V +W D ++ Sbjct: 191 KDGGALEPI-VIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEE 249 Query: 315 HSFESHKDEIFQVQWSPH--NETILASSGTDRRLHVW--DLSKIGEEQSTEDAEDGPPEL 370 +F+ H D + V WSP +++ +A++ DR + +W D E+ E P Sbjct: 250 EAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVC 309 Query: 371 LFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEE--PEIPA 422 SW+ + + S DN + +W+ EN+ E E+ Sbjct: 310 -----------WRASWSLSGNVLAISGG-DNKVTLWK--ENIQGKWESAGEVDQ 349 >5OQL-d nrPDB Length = 446 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 64/305 (20%), Positives = 114/305 (37%), Gaps = 35/305 (11%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H V + N + + + ++D PS P Q Sbjct: 108 AHNNIVKGLTFT--NDKKLLSCATDG-IKLWDPYASPSNTTPIATWQE-------GGPYT 157 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 LS++ + N + S+ I +WD+ EH + + DV ++ + S Sbjct: 158 SLSFHRSANTFAASSGQ-GCIRIWDL-----EHSTAGQAIQWPSFVDTITDVCFNQVETS 211 Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 305 + GSVA D+ ++++D R T+ P H A N + FNP LA S D + ++ Sbjct: 212 VIGSVATDRSIILFDLR---TNMPVIKTVLHFA-CNRIVFNPMEAMNLAVASEDHNIYIF 267 Query: 306 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED 365 D RN L+ + H + V++SP E L S DR + +W D Sbjct: 268 DARNFDKALNIQKGHVAAVMDVEFSPTGEE-LVSGSYDRTIRLWR-------------RD 313 Query: 366 GPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASEL 425 H ++ W + +I+ + S+D +++W+ + + + L Sbjct: 314 AGHSRDVYHTKRMQRVFRTMWTMDSKYIL-TGSDDGNVRLWRANASERSGVKATRQRQAL 372 Query: 426 ETNTA 430 E N A Sbjct: 373 EYNNA 377 Score = 66.0 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 24/155 (15%), Positives = 53/155 (34%), Gaps = 15/155 (9%) Query: 274 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHN 333 + H V + + S +A+GS D V +WDL + +H + + + + N Sbjct: 63 NGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTF--TN 120 Query: 334 ETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWI 393 + L S TD + +WD + + G + S++ + Sbjct: 121 DKKLLSCATDG-IKLWD---------PYASPSNTTPIATWQEG--GPYTSLSFHRS-ANT 167 Query: 394 ICSVSEDNIMQVWQMAENVYNDEEPEIPASELETN 428 + S +++W + + + T+ Sbjct: 168 FAASSGQGCIRIWDLEHSTAGQAIQWPSFVDTITD 202 >2YNP-A nrPDB Length = 604 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 52/274 (18%), Positives = 99/274 (36%), Gaps = 26/274 (9%) Query: 128 EGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGL 187 E V +++ + +I + + VF+Y + + H + Sbjct: 55 ETPVRAGKFIARKNWIIV-GSDDFRIRVFNYN----------TGEKVVDFEAHPDYIRSI 103 Query: 188 SWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLF 247 + +P Y+LS SDD T+ LW+ + F GH V VA++ S F Sbjct: 104 AVHPTK-PYVLSGSDDLTVKLWNWENN------WALEQTFEGHEHFVMCVAFNPKDPSTF 156 Query: 248 GSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPY-SEFILATGSADKTVALWD 306 S D+ + +W + + T VN + + P + + T S D T+ +WD Sbjct: 157 ASGCLDRTVKVWSLGQSTPNFTLTT--GQERGVNYVDYYPLPDKPYMITASDDLTIKIWD 214 Query: 307 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 366 + + + E H + + P I+ S D L +W+ S E++ + Sbjct: 215 YQTKSC-VATLEGHMSNVSFAVFHPTLP-IIISGSEDGTLKIWNSSTYKVEKTLNVGLER 272 Query: 367 PPELLFIHGGHTAKISDFSWNPNEPWIICSVSED 400 + G I+ + + + S+ D Sbjct: 273 SWCIATHPTGRKNYIAS---GFDNGFTVLSLGND 303 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 46/272 (16%), Positives = 99/272 (36%), Gaps = 45/272 (16%) Query: 170 ECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTG 229 + G+ ++P ++L+ + LW+ + + + Sbjct: 2 KLDIKKTFSNRSDRVKGIDFHP-TEPWVLTTLYSGRVELWNYETQVEVRSIQVTET---- 56 Query: 230 HTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS 289 V + + ++ +DD ++ +++ NT + +AH + ++ +P Sbjct: 57 ---PVRAGKF-IARKNWIIVGSDDFRIRVFN---YNTGEKVVDFEAHPDYIRSIAVHPTK 109 Query: 290 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 ++L +GS D TV LW+ N +FE H+ + V ++P + + AS DR + VW Sbjct: 110 PYVL-SGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVW 168 Query: 350 DLSKIGEEQSTEDAED-------------------------------GPPELLFIHGGHT 378 L + + ++ + GH Sbjct: 169 SLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHM 228 Query: 379 AKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 410 + +S ++P P II S SED +++W + Sbjct: 229 SNVSFAVFHPTLP-IIISGSEDGTLKIWNSST 259 Score = 121 bits (303), Expect = 6e-28, Method: Composition-based stats. Identities = 41/245 (16%), Positives = 82/245 (33%), Gaps = 22/245 (8%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H + P V+ + + V ++++ + GH+ Sbjct: 95 AHPDYIRSIAVHPTKPYVL-SGSDDLTVKLWNWE---------NNWALEQTFEGHEHFVM 144 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHL-LHE 244 +++NP S D T+ +W + + + TG V V ++ + Sbjct: 145 CVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLT------TGQERGVNYVDYYPLPDK 198 Query: 245 SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 304 + +DD + IWD T T++ H + V+ F+P I+ +GS D T+ + Sbjct: 199 PYMITASDDLTIKIWD---YQTKSCVATLEGHMSNVSFAVFHPTLPIII-SGSEDGTLKI 254 Query: 305 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAE 364 W+ K++ + + + P +SG D V L S + Sbjct: 255 WNSSTYKVEKTLNVGLERS-WCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDPVG 313 Query: 365 DGPPE 369 Sbjct: 314 KLVWS 318 Score = 99.9 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 55/297 (18%), Positives = 104/297 (35%), Gaps = 36/297 (12%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRL-RGHQKEG 184 HE V + P++ A+ V V+ G+ P+ L G ++ Sbjct: 138 GHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSL----------GQSTPNFTLTTGQERGV 187 Query: 185 YGLSWNPN-LNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLH 243 + + P Y+++ASDD TI +WD ++ GH + V +H Sbjct: 188 NYVDYYPLPDKPYMITASDDLTIKIWD-------YQTKSCVATLEGHMSNVSFAVFHPTL 240 Query: 244 ESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVA 303 + S ++D L IW+ ++T K T++ C++ +P D Sbjct: 241 P-IIISGSEDGTLKIWN---SSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFT 296 Query: 304 LWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDA 363 + L N + L D + ++ WS + AS + + + E S + Sbjct: 297 VLSLGNDEPTLSL-----DPVGKLVWS-GGKNAAASDIFTAVIRGNEEVEQDEPLSLQTK 350 Query: 364 EDGPPELLFIHGGHTAKISDFSWNPNEPWIICSV-SEDNIM------QVWQMAENVY 413 E G ++ H+ + + ++I + + N VW N Y Sbjct: 351 ELGSVDVFPQSLAHSPNGRFVTVVGDGEYVIYTALAWRNKAFGKCQDFVWGPDSNSY 407 Score = 92.5 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 33/192 (17%), Positives = 71/192 (36%), Gaps = 20/192 (10%) Query: 221 IDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEV 280 +D K F+ + V+ + +H + ++ ++ +W+ + + V Sbjct: 3 LDIKKTFSNRSDRVKGIDFHPTEPWVLTTL-YSGRVELWNYETQVEVRSIQVTET---PV 58 Query: 281 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 340 F +I+ GS D + +++ + K+ FE+H D I + P +L S Sbjct: 59 RAGKFIARKNWIIV-GSDDFRIRVFNYNTGE-KVVDFEAHPDYIRSIAVHPTKPYVL-SG 115 Query: 341 GTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSED 400 D + +W+ L GH + ++NP +P S D Sbjct: 116 SDDLTVKLWNWENN-------------WALEQTFEGHEHFVMCVAFNPKDPSTFASGCLD 162 Query: 401 NIMQVWQMAENV 412 ++VW + ++ Sbjct: 163 RTVKVWSLGQST 174 >2HES-X nrPDB Length = 330 Score = 144 bits (363), Expect = 7e-35, Method: Composition-based stats. Identities = 54/246 (21%), Positives = 102/246 (41%), Gaps = 27/246 (10%) Query: 189 WNPNLN-GYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLF 247 W+ + + G L + S D I L ++ + +ID + T H + VAW H SL Sbjct: 18 WSFDFSQGILATGSTDRKIKL--VSVKYDDFTLIDVLDE-TAHKKAIRSVAWRP-HTSLL 73 Query: 248 GSVADDQKLMIWDTRNNNTSK----PSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVA 303 + + D + IW + ++ H EV ++++ + LAT S DK+V Sbjct: 74 AAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDG-YYLATCSRDKSVW 132 Query: 304 LWDLRNLKL---KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 360 +W+ + + H ++ V W P E +LASS D + +W Sbjct: 133 IWETDESGEEYECISVLQEHSQDVKHVIWHPS-EALLASSSYDDTVRIW----------- 180 Query: 361 EDAEDGPPELLFIHGGHTAKISDFSW-NPNEPWIICSVSEDNIMQVWQMAENVYNDEEPE 419 D E + + GH + + + +CS S+D+ ++VW+ + +D++ Sbjct: 181 -KDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEW 239 Query: 420 IPASEL 425 + + L Sbjct: 240 VCEAIL 245 Score = 130 bits (327), Expect = 9e-31, Method: Composition-based stats. Identities = 61/302 (20%), Positives = 125/302 (41%), Gaps = 32/302 (10%) Query: 119 IEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLR 178 I++ + H+ + + P ++A + S V ++ + + E + Sbjct: 49 IDVLDETAHKKAIRSVAWRPH-TSLLAAGSFDSTVSIW---AKEESADRTFEMDLLAIIE 104 Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 GH+ E G++W+ N YL + S D ++ +W+ + + +E+ + ++ H+ V+ V Sbjct: 105 GHENEVKGVAWS-NDGYYLATCSRDKSVWIWETDESGEEY---ECISVLQEHSQDVKHVI 160 Query: 239 WHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSE-FILATGS 297 WH E+L S + D + IW ++ + ++ H V F+ F L +GS Sbjct: 161 WHP-SEALLASSSYDDTVRIWK-DYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGS 218 Query: 298 ADKTVALW-------DLRNLKLKLHSF-ESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 D TV +W D + + + HK +++ V W + ++AS G D L V+ Sbjct: 219 DDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNG--LIASVGADGVLAVY 276 Query: 350 DLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSW-NPNEPWIICSVSEDNIMQVWQM 408 + + + HG + I+ W N I+ + +D I+ W + Sbjct: 277 E--------EVDGEWKVFAKRALCHGVYE--INVVKWLELNGKTILATGGDDGIVNFWSL 326 Query: 409 AE 410 + Sbjct: 327 EK 328 >3JB9-g nrPDB Length = 558 Score = 144 bits (362), Expect = 8e-35, Method: Composition-based stats. Identities = 50/257 (19%), Positives = 96/257 (37%), Gaps = 29/257 (11%) Query: 157 DYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPK 216 + ++ P + + +GH K L + P LLS S D+ I +W++ Sbjct: 242 NLSEEPGEQTCYIPKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDR- 300 Query: 217 EHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAH 276 F GH + D+++ S F S + D+ + +WDT ++ Sbjct: 301 -----SLLRTFQGHARPIRDLSFSQDGRS-FLSTSFDKTIKLWDTELGKCLNCFNS---- 350 Query: 277 TAEVNCLSFN--PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE 334 NC+ F P G+ADK + +D+R+ + + +++ H I + + + + Sbjct: 351 DRLTNCVKFQVDPDKPNEFLAGTADKRILQFDIRSPDI-VQAYDHHLGGINSITFLENGK 409 Query: 335 TILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWII 394 + +S D + W+ P + F+ + + PN I Sbjct: 410 RFVTTSD-DSSMRFWEYGT-------------PVPIKFVADIAMHSMPRVALRPNGKSIA 455 Query: 395 CSVSEDNIMQVWQMAEN 411 C S DN + V+ E Sbjct: 456 CQ-SLDNCIYVYSAYEK 471 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 48/324 (14%), Positives = 100/324 (30%), Gaps = 71/324 (21%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H ++ R+ P + ++ + + + + +++ S +GH + Sbjct: 264 GHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLL---------RTFQGHARPIR 314 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEH--------------------------- 218 LS++ + LS S D TI LWD + Sbjct: 315 DLSFSQD-GRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGT 373 Query: 219 ----------RVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSK 268 R D + H + + + + F + +DD + W+ K Sbjct: 374 ADKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKR-FVTTSDDSSMRFWEYGTPVPIK 432 Query: 269 PSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW----DLRNLKLKLHSFESHKDEI 324 + H+ ++ P + I A S D + ++ R K K+ S Sbjct: 433 FVADIAMHSMP--RVALRPNGKSI-ACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYS 489 Query: 325 FQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDF 384 +V +SP + S + WD +L+ H+ + Sbjct: 490 LEVGFSPDGR-FVFSGDSSGNACFWDWKTC--------------KLMAKLPAHSGPVQSM 534 Query: 385 SWNPNEPWIICSVS-EDNIMQVWQ 407 +++P E + + S D ++ W Sbjct: 535 AFHPQETSKVATSSIVDGSIKYWD 558 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 42/211 (19%), Positives = 80/211 (37%), Gaps = 22/211 (10%) Query: 202 DDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDT 261 +D I L + + + GHT + + + + L S + D ++ IW+ Sbjct: 237 NDVGINLSEEPGEQTCYIPKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEV 296 Query: 262 RNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHK 321 + T H + LSF+ L+T S DKT+ LWD K L+ F S + Sbjct: 297 --YHDRSLLRTFQGHARPIRDLSFSQDGRSFLST-SFDKTIKLWDTELGKC-LNCFNSDR 352 Query: 322 DEIFQVQW--SPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTA 379 V++ P + D+R+ +D+ P+++ + H Sbjct: 353 -LTNCVKFQVDPDKPNEFLAGTADKRILQFDIRS--------------PDIVQAYDHHLG 397 Query: 380 KISDFSWNPNEPWIICSVSEDNIMQVWQMAE 410 I+ ++ N + S+D+ M+ W+ Sbjct: 398 GINSITFLENGK-RFVTTSDDSSMRFWEYGT 427 Score = 41.3 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 16/62 (25%), Positives = 29/62 (46%) Query: 350 DLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMA 409 D+ E+ E P + +F GHT IS + P ++ S S DN +++W++ Sbjct: 238 DVGINLSEEPGEQTCYIPKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVY 297 Query: 410 EN 411 + Sbjct: 298 HD 299 >3JB9-L nrPDB Length = 340 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 59/305 (19%), Positives = 109/305 (35%), Gaps = 34/305 (11%) Query: 110 GGFGSVCGKIEIE--IKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEP 167 G + + H EV AR+ P A+ +L+++ Sbjct: 30 GSVLQRTSDLNVPNLQMFGHTAEVLVARFDPS-GSYFASGGMDRQILLWNV--------- 79 Query: 168 SGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIF 227 G+ + L G + L W+ + S+S D + WD + K + Sbjct: 80 FGDVKNYGVLNGCKGAITDLQWSRDSRVVYCSSS-DTHLMSWDAVSGQKIRK-------H 131 Query: 228 TGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP 287 GH VV + + L SV+DD + +WD+R+ + K + ++ Sbjct: 132 KGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIEE----KYPLTAVAIAQ 187 Query: 288 YSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLH 347 + G D + +WDLRN H + HKD I + S ++L S+ D + Sbjct: 188 QGTQVFI-GGIDGAIKIWDLRNNHCS-HVLKGHKDIITSLAISKDGSSLL-SNSMDNTVR 244 Query: 348 VWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 ++D+ Q +G G + +W+ N ++ + S D + VW Sbjct: 245 IFDVKPFASAQRQLQIFEGAI------HGQEHNLLGVAWSRNSRFV-GAGSSDKNVYVWS 297 Query: 408 MAENV 412 ++ Sbjct: 298 ATGDL 302 Score = 81.4 bits (199), Expect = 8e-16, Method: Composition-based stats. Identities = 33/169 (19%), Positives = 70/169 (41%), Gaps = 18/169 (10%) Query: 137 MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGY 196 + Q + + ++D + L+GH+ L+ + + + Sbjct: 185 IAQQGTQVFIGGIDGAIKIWDLRNNHC----------SHVLKGHKDIITSLAISKDGSS- 233 Query: 197 LLSASDDHTICLWDINATPKEHRVIDA-KNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 255 LLS S D+T+ ++D+ R + + G + VAW + G+ + D+ Sbjct: 234 LLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWS-RNSRFVGAGSSDKN 292 Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 304 + +W + T + + H VN + F+P+ + IL + S+D+T+ L Sbjct: 293 VYVW----SATGDLRYVLPGHEGSVNHVDFHPHQDIIL-SCSSDRTIFL 336 >5K1B-B nrPDB Length = 677 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 48/236 (20%), Positives = 91/236 (38%), Gaps = 34/236 (14%) Query: 181 QKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH 240 + L +P LN +A D I +W +N ++ + ++ HT V D+ Sbjct: 30 RNGVNALQLDPALNRLF-TAGRDSIIRIWSVNQHKQDPYIASMEH----HTDWVNDIVLC 84 Query: 241 LLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADK 300 ++L S + D + +W+ + T+ H V L++ E ++A+ D+ Sbjct: 85 CNGKTLI-SASSDTTVKVWN---AHKGFCMSTLRTHKDYVKALAYAKDKE-LVASAGLDR 139 Query: 301 TVALWDLR--------NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLS 352 + LWD+ N + S +KD I+ + + TI+ S T++ L VWD Sbjct: 140 QIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLG-TIIVSGSTEKVLRVWDPR 198 Query: 353 KIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 + + GHT + N + S S D +++W + Sbjct: 199 TCAKLMKLK--------------GHTDNVKALLLNRDGTQ-CLSGSSDGTIRLWSL 239 Score = 115 bits (287), Expect = 4e-26, Method: Composition-based stats. Identities = 49/264 (18%), Positives = 96/264 (36%), Gaps = 33/264 (12%) Query: 146 TKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHT 205 T S + ++ +H P + H + L+SAS D T Sbjct: 47 TAGRDSIIRIWSVNQHKQDPY-------IASMEHHTDWVNDIVLC-CNGKTLISASSDTT 98 Query: 206 ICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRN-- 263 + +W+ + + H V+ +A+ + L S D+++ +WD Sbjct: 99 VKVWNAHKG-------FCMSTLRTHKDYVKALAYA-KDKELVASAGLDRQIFLWDVNTLT 150 Query: 264 ----NNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES 319 +N + + ++ + + L+ N I+ +GS +K + +WD R KL + Sbjct: 151 ALTASNNTVTTSSLSGNKDSIYSLAMNQLGT-IIVSGSTEKVLRVWDPRT-CAKLMKLKG 208 Query: 320 HKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFI------ 373 H D + + + + T S +D + +W L + + ++G L Sbjct: 209 HTDNVKALLLN-RDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHV 267 Query: 374 -HGGHTAKISDFSW-NPNEPWIIC 395 GG KI NP+ +IC Sbjct: 268 YSGGRDRKIYCTDLRNPDIRVLIC 291 Score = 97.5 bits (241), Expect = 9e-21, Method: Composition-based stats. Identities = 34/180 (18%), Positives = 77/180 (42%), Gaps = 10/180 (5%) Query: 231 TAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSE 290 V + LF + D + IW + +++ HT VN + + Sbjct: 30 RNGVNALQLDPALNRLF-TAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88 Query: 291 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWD 350 ++ + S+D TV +W+ + + + +HKD + + ++ ++ ++AS+G DR++ +WD Sbjct: 89 TLI-SASSDTTVKVWNA-HKGFCMSTLRTHKDYVKALAYA-KDKELVASAGLDRQIFLWD 145 Query: 351 LSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 410 ++ + ++ + G+ I + N II S S + +++VW Sbjct: 146 VNTLTALTASNNTVTTSS-----LSGNKDSIYSLAMNQLGT-IIVSGSTEKVLRVWDPRT 199 Score = 85.2 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 48/307 (15%), Positives = 107/307 (34%), Gaps = 26/307 (8%) Query: 127 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 186 H+ V Y ++ ++A+ + ++D + S L G++ Y Sbjct: 116 HKDYVKALAY-AKDKELVASAGLDRQIFLWDVNT-LTALTASNNTVTTSSLSGNKDSIYS 173 Query: 187 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 246 L+ N L ++S S + + +WD R GHT V+ + + Sbjct: 174 LAMN-QLGTIIVSGSTEKVLRVWD-------PRTCAKLMKLKGHTDNVKALLLNRDGTQ- 224 Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 S + D + +W + T H V L N + + +G D+ + D Sbjct: 225 CLSGSSDGTIRLWSLGQQ---RCIATYRVHDEGVWALQVN-DAFTHVYSGGRDRKIYCTD 280 Query: 307 LRNLKLKLHSFESHKDEI--FQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAE 364 LRN +++ E K + ++ S + + T ++ W L I +++ D + Sbjct: 281 LRNPDIRVLICEE-KAPVLKMELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYD 339 Query: 365 DGPPELLFIHGGH-------TAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEE 417 + + A I ++ I+ + +N+ W + + ++ Sbjct: 340 NDCTNPITPLCTQPDQVIKGGASIIQCHILNDKRHILTKDTNNNVAY-WDVLKACKVEDL 398 Query: 418 PEIPASE 424 ++ + Sbjct: 399 GKVDFED 405 Score = 66.7 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 23/138 (16%), Positives = 47/138 (34%), Gaps = 19/138 (13%) Query: 277 TAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL--KLHSFESHKDEIFQVQWSPHNE 334 VN L +P + T D + +W + K + S E H D + + + + Sbjct: 30 RNGVNALQLDPALNRLF-TAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88 Query: 335 TILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWII 394 T++ S+ +D + VW+ K + +D L + ++ Sbjct: 89 TLI-SASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKD---------------KELV 132 Query: 395 CSVSEDNIMQVWQMAENV 412 S D + +W + Sbjct: 133 ASAGLDRQIFLWDVNTLT 150 >6EOJ-D nrPDB Length = 470 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 71/359 (19%), Positives = 137/359 (38%), Gaps = 41/359 (11%) Query: 48 SLTAQWLPDVTKQDGKDYSVHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKG 107 S T +P G+D ++ TH S + +I ++Q E + + Y G Sbjct: 60 SYTIDIMP-PNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYS---G 115 Query: 108 EFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEP 167 EF + + E ++ H+ V +Y ++ + + + ++ K Sbjct: 116 EFSLWNASSFTFETLMQ-AHDSAVTTMKY-SHDSDWMISGDADGMIKIWQPNFSMVKEID 173 Query: 168 SGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIF 227 + H + ++++ N + ++ SDD+ + +W+ + +E + Sbjct: 174 A----------AHTESIRDMAFSSNDSK-FVTCSDDNILKIWNFSNGKQE-------RVL 215 Query: 228 TGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP 287 +GH V+ WH L S + D + +WD R+ N HT V F P Sbjct: 216 SGHHWDVKSCDWHPEM-GLIASASKDNLVKLWDPRSGNCISSILKFK-HT--VLKTRFQP 271 Query: 288 YSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLH 347 +L S DK+ ++D+R +L D ++W P NE++ + D L Sbjct: 272 TKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDY-MTLEWHPINESMFTLACYDGSLK 330 Query: 348 VWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 +DL + E +L I H I+ S+NP I + ++D ++ W Sbjct: 331 HFDLLQNLNEP-----------ILTIPYAHDKCITSLSYNPVG-HIFATAAKDRTIRFW 377 Score = 117 bits (294), Expect = 7e-27, Method: Composition-based stats. Identities = 54/357 (15%), Positives = 126/357 (35%), Gaps = 26/357 (7%) Query: 31 NTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRLILGTHTSDEQNHLLIASVQL 90 N P + + ++ ++ QW P+ + YS + + + + + Sbjct: 79 NLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAV 138 Query: 91 PSEDAQFDGSHYDNEKGE-FGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTP 149 + D + + + EI H + + N T + Sbjct: 139 TTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAF-SSNDSKFVTCSD 197 Query: 150 SSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLW 209 + + +++++ + + L GH + W+P G + SAS D+ + LW Sbjct: 198 DNILKIWNFS----------NGKQERVLSGHHWDVKSCDWHP-EMGLIASASKDNLVKLW 246 Query: 210 DINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKP 269 D + ++ K V + +L +++ D+ ++D R + K Sbjct: 247 DPRSGNCISSILKFK-------HTVLKTRFQPTKGNLLMAISKDKSCRVFDIRY--SMKE 297 Query: 270 SHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL-RNLKLKLHSF-ESHKDEIFQV 327 V T + L ++P +E + D ++ +DL +NL + + +H I + Sbjct: 298 LMCVRDETDYMT-LEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSL 356 Query: 328 QWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDF 384 ++P I A++ DR + W ++ + + +D ++ G I+ Sbjct: 357 SYNPVGH-IFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAV 412 Score = 91.8 bits (226), Expect = 6e-19, Method: Composition-based stats. Identities = 33/180 (18%), Positives = 73/180 (40%), Gaps = 22/180 (12%) Query: 232 AVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEF 291 V+ + W L + +W+ ++ + AH + V + ++ S++ Sbjct: 94 HVIPAIQWTPEGRRLVV-ATYSGEFSLWN---ASSFTFETLMQAHDSAVTTMKYSHDSDW 149 Query: 292 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 ++ +G AD + +W N + +H + I + +S N++ + D L +W+ Sbjct: 150 MI-SGDADGMIKIWQ-PNFSMVKEIDAAHTESIRDMAFS-SNDSKFVTCSDDNILKIWNF 206 Query: 352 SKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 S +E+ + GH + W+P E +I S S+DN++++W Sbjct: 207 SNGKQER--------------VLSGHHWDVKSCDWHP-EMGLIASASKDNLVKLWDPRSG 251 >5UZ7-B nrPDB Length = 351 Score = 136 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 60/279 (21%), Positives = 99/279 (35%), Gaps = 38/279 (13%) Query: 130 EVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW 189 V Y P V A + +++ G + L GH + Sbjct: 110 WVMTCAYAPSGNYV-ACGGLDNICSIYNLKTR------EGNVRVSRELAGHTGYLSCCRF 162 Query: 190 NPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGS 249 + ++++S D T LWDI + HT V ++ LF S Sbjct: 163 --LDDNQIVTSSGDTTCALWDIETGQQTTTFTG-------HTGDVMSLSLAP-DTRLFVS 212 Query: 250 VADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR- 308 A D +WD R T H +++N + F P + ATGS D T L+DLR Sbjct: 213 GACDASAKLWDVRE---GMCRQTFTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRA 268 Query: 309 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPP 368 + +L +S ++ I V +S +LA D +VWD K Sbjct: 269 DQELMTYSHDNIICGITSVSFSKSGRLLLAGYD-DFNCNVWDALKADRAG---------- 317 Query: 369 ELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 + GH ++S + + + S D+ +++W Sbjct: 318 ----VLAGHDNRVSCLGVTDDG-MAVATGSWDSFLKIWN 351 Score = 132 bits (331), Expect = 4e-31, Method: Composition-based stats. Identities = 51/250 (20%), Positives = 96/250 (38%), Gaps = 31/250 (12%) Query: 162 PSKPEPSGECQPDLR--LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHR 219 + +P G Q R LRGH + Y + W + + L+SAS D + +WD T K H Sbjct: 45 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTD-SRLLVSASQDGKLIIWDSYTTNKVHA 103 Query: 220 VIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTS-KPSHTVDAHTA 278 + ++ V A+ + D I++ + + + S + HT Sbjct: 104 IPL-------RSSWVMTCAYAPSG-NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTG 155 Query: 279 EVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 338 ++C F ++ + T S D T ALWD+ + H ++ + +P + Sbjct: 156 YLSCCRFLDDNQ--IVTSSGDTTCALWDIETGQQTTTF-TGHTGDVMSLSLAPDTR-LFV 211 Query: 339 SSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVS 398 S D +WD+ + Q+ GH + I+ + PN + S Sbjct: 212 SGACDASAKLWDVREGMCRQT--------------FTGHESDINAICFFPNG-NAFATGS 256 Query: 399 EDNIMQVWQM 408 +D +++ + Sbjct: 257 DDATCRLFDL 266 Score = 95.2 bits (235), Expect = 4e-20, Method: Composition-based stats. Identities = 38/218 (17%), Positives = 80/218 (36%), Gaps = 29/218 (13%) Query: 212 NATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSH 271 N P + + GH A + + W L S + D KL+IWD + T+ H Sbjct: 47 NIDPVGRIQMRTRRTLRGHLAKIYAMHWGT-DSRLLVSASQDGKLIIWD---SYTTNKVH 102 Query: 272 TVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS---FESHKDEIFQVQ 328 + ++ V ++ P + +A G D ++++L+ + + H + + Sbjct: 103 AIPLRSSWVMTCAYAPSGNY-VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCR 161 Query: 329 WSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNP 388 + ++ + +S D +WD+ + + HT + S P Sbjct: 162 F--LDDNQIVTSSGDTTCALWDIETGQQTTTFTG--------------HTGDVMSLSLAP 205 Query: 389 NEPWIICSVSEDNIMQVWQMAEN----VYNDEEPEIPA 422 + + S + D ++W + E + E +I A Sbjct: 206 D-TRLFVSGACDASAKLWDVREGMCRQTFTGHESDINA 242 >5A31-R nrPDB Length = 386 Score = 134 bits (337), Expect = 7e-32, Method: Composition-based stats. Identities = 55/276 (19%), Positives = 103/276 (37%), Gaps = 31/276 (11%) Query: 88 VQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEI------EIKINHEGEVNRARYMPQNA 141 V L + ++ + G G G +EI + G ++R + N Sbjct: 125 VHLCDTENEYTSLSW-IGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNN 183 Query: 142 CVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSAS 201 V+ + + +L D P+P E + H +E GL WN N L S Sbjct: 184 HVLTSGSRDHRILHRDV----RMPDPFFE-----TIESHTQEVCGLKWNVADNK-LASGG 233 Query: 202 DDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVAD--DQKLMIW 259 +D+ + ++ E F H A V+ +AW + + D++L IW Sbjct: 234 NDNVVHVY-------EGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIW 286 Query: 260 DTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES 319 + NTS +D+ + N + +E + + G + + LWD ++ + + Sbjct: 287 NV---NTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMD-PIAILKG 342 Query: 320 HKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIG 355 H + + S T+++ +G D L W L + Sbjct: 343 HSFRVLHLTLSNDGTTVVSGAG-DETLRYWKLFDVS 377 Score = 82.5 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 36/180 (20%), Positives = 72/180 (40%), Gaps = 24/180 (13%) Query: 235 EDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILA 294 ++W L + + I+D K T+ H V CLS+N +L Sbjct: 135 TSLSWIGAGSHL-AVGQANGLVEIYDVMK---RKCIRTLSGHIDRVACLSWN---NHVLT 187 Query: 295 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKI 354 +GS D + D+R + ESH E+ ++W+ + LAS G D +HV++ + Sbjct: 188 SGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNK-LASGGNDNVVHVYEGTS- 245 Query: 355 GEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVS--EDNIMQVWQMAENV 412 + H A + +W+P++ ++ + D +++W + ++ Sbjct: 246 -------------KSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSI 292 >5Z56-q nrPDB Length = 504 Score = 134 bits (337), Expect = 8e-32, Method: Composition-based stats. Identities = 61/301 (20%), Positives = 114/301 (37%), Gaps = 55/301 (18%) Query: 137 MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGY 196 P + I T +V+VFD + Q L+GH K+ + ++P+ + Sbjct: 230 CPSDTNKILTGGADKNVVVFDKSSE----------QILATLKGHTKKVTSVVFHPSQD-L 278 Query: 197 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 256 + SAS D TI +W + + H + V ++ H + L S +DDQ Sbjct: 279 VFSASPDATIRIWSVPNA-------SCVQVVRAHESAVTGLSLHATGDYLL-SSSDDQY- 329 Query: 257 MIWDTRNNNTSKPSHTVDAHTAEV--NCLSFNPYSEFILATGSADKTVALWDLRNLKLKL 314 W + T + V T+ C F+P I TG+ D + +WDL+ + + Sbjct: 330 --WAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDG-LIFGTGTMDSQIKIWDLKE-RTNV 385 Query: 315 HSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTE-DAEDGPPELLFI 373 +F H I + +S + LA++ D + +WDL K+ ++ + D L+F Sbjct: 386 ANFPGHSGPITSIAFSENG-YYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFD 444 Query: 374 HGG--------------------------HTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 G H+ + ++ + + I S D ++ + Sbjct: 445 QSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKF-IASTGMDRSLKFYS 503 Query: 408 M 408 + Sbjct: 504 L 504 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 44/257 (17%), Positives = 98/257 (38%), Gaps = 36/257 (14%) Query: 162 PSKPEPSGECQPDLRLRGHQK-------EGYGLSWNPNLNGYLLSASDDHTICLWDINAT 214 P + E ++ H L P+ +L+ D + ++D ++ Sbjct: 195 PEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSE 254 Query: 215 PKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVD 274 GHT V V +H + +F S + D + IW N + V Sbjct: 255 Q-------ILATLKGHTKKVTSVVFHPSQDLVF-SASPDATIRIWSVPNAS---CVQVVR 303 Query: 275 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE-IFQVQWSPHN 333 AH + V LS + +++L++ S D+ A D++ ++ + + Q+ P Sbjct: 304 AHESAVTGLSLHATGDYLLSS-SDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDG 362 Query: 334 ETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWI 393 I + D ++ +WDL + + GH+ I+ +++ N ++ Sbjct: 363 -LIFGTGTMDSQIKIWDLKERTN--------------VANFPGHSGPITSIAFSENGYYL 407 Query: 394 ICSVSEDNIMQVWQMAE 410 + ++D+ +++W + + Sbjct: 408 -ATAADDSSVKLWDLRK 423 >4BH6-A nrPDB Length = 308 Score = 131 bits (330), Expect = 4e-31, Method: Composition-based stats. Identities = 55/272 (20%), Positives = 102/272 (37%), Gaps = 31/272 (11%) Query: 88 VQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEI------EIKINHEGEVNRARYMPQNA 141 V L + ++ + G G G +EI + G ++R + N Sbjct: 56 VHLCDTENEYTSLSW-IGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNN 114 Query: 142 CVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSAS 201 V+ + + +L D P+P E + H +E GL WN N L S Sbjct: 115 HVLTSGSRDHRILHRDV----RMPDPFFE-----TIESHTQEVCGLKWNVADNK-LASGG 164 Query: 202 DDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVAD--DQKLMIW 259 +D+ + ++ E F H A V+ +AW + + D++L IW Sbjct: 165 NDNVVHVY-------EGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIW 217 Query: 260 DTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES 319 + NTS +D+ + N + +E + + G + + LWD ++ + + Sbjct: 218 NV---NTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMD-PIAILKG 273 Query: 320 HKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 H + + S T+++ +G D L W L Sbjct: 274 HSFRVLHLTLSNDGTTVVSGAG-DETLRYWKL 304 Score = 81.0 bits (198), Expect = 9e-16, Method: Composition-based stats. Identities = 36/180 (20%), Positives = 72/180 (40%), Gaps = 24/180 (13%) Query: 235 EDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILA 294 ++W L + + I+D K T+ H V CLS+N +L Sbjct: 66 TSLSWIGAGSHL-AVGQANGLVEIYDVMK---RKCIRTLSGHIDRVACLSWN---NHVLT 118 Query: 295 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKI 354 +GS D + D+R + ESH E+ ++W+ + LAS G D +HV++ + Sbjct: 119 SGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNK-LASGGNDNVVHVYEGTS- 176 Query: 355 GEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVS--EDNIMQVWQMAENV 412 + H A + +W+P++ ++ + D +++W + ++ Sbjct: 177 -------------KSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSI 223 Score = 35.9 bits (81), Expect = 0.036, Method: Composition-based stats. Identities = 19/125 (15%), Positives = 36/125 (28%), Gaps = 36/125 (28%) Query: 126 NHEGEVNRARYMPQNACVIATKTP--SSDVLVFD-------------------------- 157 H+ V + P V+AT + +++ Sbjct: 185 EHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTN 244 Query: 158 -------YTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWD 210 Y+K+ P L+GH L+ + N ++S + D T+ W Sbjct: 245 ELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLS-NDGTTVVSGAGDETLRYWK 303 Query: 211 INATP 215 + P Sbjct: 304 LFDKP 308 >4LG8-A nrPDB Length = 354 Score = 131 bits (329), Expect = 6e-31, Method: Composition-based stats. Identities = 61/301 (20%), Positives = 114/301 (37%), Gaps = 55/301 (18%) Query: 137 MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGY 196 P + I T +V+VFD + Q L+GH K+ + ++P+ + Sbjct: 80 CPSDTNKILTGGADKNVVVFDKSSE----------QILATLKGHTKKVTSVVFHPSQD-L 128 Query: 197 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 256 + SAS D TI +W + + H + V ++ H + L S +DDQ Sbjct: 129 VFSASPDATIRIWSVPNA-------SCVQVVRAHESAVTGLSLHATGDYLL-SSSDDQY- 179 Query: 257 MIWDTRNNNTSKPSHTVDAHTAEV--NCLSFNPYSEFILATGSADKTVALWDLRNLKLKL 314 W + T + V T+ C F+P I TG+ D + +WDL+ + + Sbjct: 180 --WAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDG-LIFGTGTMDSQIKIWDLKE-RTNV 235 Query: 315 HSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTE-DAEDGPPELLFI 373 +F H I + +S + LA++ D + +WDL K+ ++ + D L+F Sbjct: 236 ANFPGHSGPITSIAFSENG-YYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFD 294 Query: 374 HGG--------------------------HTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 G H+ + ++ + + I S D ++ + Sbjct: 295 QSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKF-IASTGMDRSLKFYS 353 Query: 408 M 408 + Sbjct: 354 L 354 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 44/257 (17%), Positives = 98/257 (38%), Gaps = 36/257 (14%) Query: 162 PSKPEPSGECQPDLRLRGHQK-------EGYGLSWNPNLNGYLLSASDDHTICLWDINAT 214 P + E ++ H L P+ +L+ D + ++D ++ Sbjct: 45 PEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSE 104 Query: 215 PKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVD 274 GHT V V +H + +F S + D + IW N + V Sbjct: 105 Q-------ILATLKGHTKKVTSVVFHPSQDLVF-SASPDATIRIWSVPNAS---CVQVVR 153 Query: 275 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE-IFQVQWSPHN 333 AH + V LS + +++L++ S D+ A D++ ++ + + Q+ P Sbjct: 154 AHESAVTGLSLHATGDYLLSS-SDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDG 212 Query: 334 ETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWI 393 I + D ++ +WDL + + GH+ I+ +++ N ++ Sbjct: 213 -LIFGTGTMDSQIKIWDLKERTN--------------VANFPGHSGPITSIAFSENGYYL 257 Query: 394 ICSVSEDNIMQVWQMAE 410 + ++D+ +++W + + Sbjct: 258 -ATAADDSSVKLWDLRK 273 >6Q8F-A nrPDB Length = 514 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 51/322 (15%), Positives = 115/322 (35%), Gaps = 55/322 (17%) Query: 123 IKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQK 182 IK + V AR+ P + + T + + V+++T + + + Q + + Sbjct: 210 IKFGQKSHVECARFSP-DGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMM--DD 266 Query: 183 EGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLL 242 + ++ + L + + D I +W I + R H+ V +++ Sbjct: 267 AVLCMCFSRDTE-MLATGAQDGKIKVWKIQSGQCLRRFER------AHSKGVTCLSFS-K 318 Query: 243 HESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTV 302 S S + DQ + I ++ T K H++ VN +F +I+ + S+D TV Sbjct: 319 DSSQILSASFDQTIRIHGLKSGKTLK---EFRGHSSFVNEATFTQDGHYII-SASSDGTV 374 Query: 303 ALWDLRNLKLKLHSFESHKD------EIFQVQWSPHNETILASSGTDRRLHV-------- 348 +W+++ + ++F+S + V P N + + Sbjct: 375 KIWNMKTTECS-NTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIV 433 Query: 349 -----------------------WDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFS 385 W + +GE+ +L H + + Sbjct: 434 RSFSSGKREGGDFVCCALSPRGEW-IYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIA 492 Query: 386 WNPNEPWIICSVSEDNIMQVWQ 407 +P++ +I + SED ++++W+ Sbjct: 493 HHPHQ-NLIATYSEDGLLKLWK 513 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 45/263 (17%), Positives = 98/263 (37%), Gaps = 21/263 (7%) Query: 157 DYTKHPSKPEPSGECQPDLRLRGH-----QKEGYGLSWNPNLNGYLLSASDDHTICLWDI 211 D + + + E + +L H + ++P+ YL++ S D I +W+ Sbjct: 186 DLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPD-GQYLVTGSVDGFIEVWNF 244 Query: 212 NATP-KEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPS 270 ++ A++ F V + + + + A D K+ +W ++ + Sbjct: 245 TTGKIRKDLKYQAQDNFMMMDDAVLCMCFS-RDTEMLATGAQDGKIKVWKIQSGQCLRRF 303 Query: 271 HTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWS 330 AH+ V CLSF+ S IL + S D+T+ + L++ K L F H + + ++ Sbjct: 304 E--RAHSKGVTCLSFSKDSSQIL-SASFDQTIRIHGLKSGKT-LKEFRGHSSFVNEATFT 359 Query: 331 PHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNE 390 I+ S+ +D + +W++ + + G ++ P Sbjct: 360 QDGHYII-SASSDGTVKIWNMKTTECSNTFKSLGSTA--------GTDITVNSVILLPKN 410 Query: 391 PWIICSVSEDNIMQVWQMAENVY 413 P + N + + M + Sbjct: 411 PEHFVVCNRSNTVVIMNMQGQIV 433 >5WLC-LO nrPDB Length = 923 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 53/253 (20%), Positives = 103/253 (40%), Gaps = 22/253 (8%) Query: 137 MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPD---LRLRGHQKEGYGLSWNPNL 193 M QN + + + L F +K E Q + L+ +GH L+++P+ Sbjct: 300 MGQNPVNTVSVNQTGEWLAFGSSKLGQLL--VYEWQSESYILKQQGHFDSTNSLAYSPD- 356 Query: 194 NGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADD 253 +++AS+D I +WDI + F HT+ V V + + +F S + D Sbjct: 357 GSRVVTASEDGKIKVWDITSG-------FCLATFEEHTSSVTAVQFAKRGQVMF-SSSLD 408 Query: 254 QKLMIWDTRNNNTSKPSHTVDAHTA-EVNCLSFNPYSEFILATGSADK-TVALWDLRNLK 311 + WD + T + NCL+ +P E ++ GS D + +W ++ + Sbjct: 409 GTVRAWDL---IRYRNFRTFTGTERIQFNCLAVDPSGE-VVCAGSLDNFDIHVWSVQTGQ 464 Query: 312 LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELL 371 L L + H+ + + +S N ++LAS+ D+ + +W + ++ + L Sbjct: 465 L-LDALSGHEGPVSCLSFSQEN-SVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALS 522 Query: 372 FIHGGHTAKISDF 384 G +S Sbjct: 523 MRPDGKEVAVSTL 535 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 61/376 (16%), Positives = 127/376 (33%), Gaps = 63/376 (16%) Query: 92 SEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSS 151 S+D++F + + + S + H V + + I T + Sbjct: 155 SQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMG-AFFSHDQEKIYTVSKDG 213 Query: 152 DVLVFDYTKHPS-----------KPEPSGECQPDLRLR------GHQKEGYGLSWNPNLN 194 V V+++TK PS K E + R+ +Q + ++++P Sbjct: 214 AVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPAT- 272 Query: 195 GYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQ 254 L L+D+ + V V+ + E L + Sbjct: 273 RLLAVGFTSGEFRLYDLPD-------FTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLG 325 Query: 255 KLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL 314 +L++++ ++ + H N L+++P ++ T S D + +WD+ + L Sbjct: 326 QLLVYEWQSESY---ILKQQGHFDSTNSLAYSPDGSRVV-TASEDGKIKVWDITSG-FCL 380 Query: 315 HSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFI- 373 +FE H + VQ++ + ++ SS D + WDL + ++ E L + Sbjct: 381 ATFEEHTSSVTAVQFAKRGQ-VMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVD 439 Query: 374 -----------------------------HGGHTAKISDFSWNPNEPWIICSVSEDNIMQ 404 GH +S S++ E ++ S S D ++ Sbjct: 440 PSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QENSVLASASWDKTIR 498 Query: 405 VWQMAENVYNDEEPEI 420 +W + E E+ Sbjct: 499 IWSIFGRSQQVEPIEV 514 Score = 102 bits (253), Expect = 4e-22, Method: Composition-based stats. Identities = 42/303 (13%), Positives = 98/303 (32%), Gaps = 50/303 (16%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H ++ + Q++ I T + ++ + GH+ Sbjct: 144 GHFQDITSLTW-SQDSRFILTTSKDLSAKIWSVDSEEKNLAAT-------TFNGHRDYVM 195 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRV--------------------IDAKN 225 G ++ + + + S D + +W+ P + I K+ Sbjct: 196 G-AFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKH 254 Query: 226 IFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSF 285 F + A V+ V +H L + ++D + + VN +S Sbjct: 255 FFYANQAKVKCVTFHP-ATRLLAVGFTSGEFRLYDLPD---FTLIQQLSMGQNPVNTVSV 310 Query: 286 NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRR 345 N E++ S + +++ ++ L + H D + +SP ++ ++ D + Sbjct: 311 NQTGEWLAFGSSKLGQLLVYEWQSESYILKQ-QGHFDSTNSLAYSPDGSRVV-TASEDGK 368 Query: 346 LHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQV 405 + VWD++ L HT+ ++ + + S S D ++ Sbjct: 369 IKVWDITSG--------------FCLATFEEHTSSVTAVQFAKRGQVMF-SSSLDGTVRA 413 Query: 406 WQM 408 W + Sbjct: 414 WDL 416 Score = 91.4 bits (225), Expect = 7e-19, Method: Composition-based stats. Identities = 39/288 (13%), Positives = 91/288 (31%), Gaps = 63/288 (21%) Query: 181 QKEGYGLSWNPNLNGYLLSASDDHTICLWDIN--ATPKEHRVIDAKNIFTGHTAVVEDVA 238 +++ + ++P+ + L++ + +W ++ + GH + + Sbjct: 96 KEKCSAVKFSPDGRLFALASG--RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLT 153 Query: 239 WHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSA 298 W + + + D IW + + + T + H V F+ E I T S Sbjct: 154 WSQDSRFILTT-SKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIY-TVSK 211 Query: 299 DKTVALW-----------------------DLRNLKLKL---HSFESHKDEIFQVQWSPH 332 D V +W D+ ++ H F +++ ++ V + P Sbjct: 212 DGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPA 271 Query: 333 NETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPP------------------------ 368 +LA T ++DL Q ++ Sbjct: 272 TR-LLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVY 330 Query: 369 -----ELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 + GH + +++P+ ++ + SED ++VW + Sbjct: 331 EWQSESYILKQQGHFDSTNSLAYSPDGSRVV-TASEDGKIKVWDITSG 377 Score = 69.0 bits (167), Expect = 4e-12, Method: Composition-based stats. Identities = 35/225 (15%), Positives = 82/225 (36%), Gaps = 32/225 (14%) Query: 198 LSASDDHTICLWDINATPKEHRVIDAKN-IFT-GHTAVVEDVAWHLLHESLFGSVADDQK 255 ++ SDD L + +I+ K+ F H + + + L S+ +D + Sbjct: 20 ITFSDDGKQLLSPVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGT-LLISIDEDGR 78 Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI-LATGSADKTVALWDLRNLK--- 311 ++ + + N + + + + + F+P LA+G + +W ++ Sbjct: 79 AILVNFKARNVLHHFNFKE----KCSAVKFSPDGRLFALASGRF---LQIWKTPDVNKDR 131 Query: 312 -----LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 366 ++ H +I + WS + IL +S D +W + + + Sbjct: 132 QFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTS-KDLSAKIWSVDSEEKNLAA------ 184 Query: 367 PPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 GH + ++ ++ I +VS+D + VW+ + Sbjct: 185 -----TTFNGHRDYVMGAFFSHDQEK-IYTVSKDGAVFVWEFTKR 223 Score = 59.8 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 36/235 (15%), Positives = 76/235 (32%), Gaps = 62/235 (26%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPS---------------KPEPSGE 170 H V ++ + V+ + + V +D ++ + +PSGE Sbjct: 385 EHTSSVTAVQF-AKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGE 443 Query: 171 -------------------CQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDI 211 Q L GH+ LS++ N L SAS D TI +W I Sbjct: 444 VVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QENSVLASASWDKTIRIWSI 502 Query: 212 NATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNN------- 264 ++ I+ + V ++ + + S ++ I++ + Sbjct: 503 FGRSQQVEPIEVY-------SDVLALSMRPDGKEVAVS-TLKGQISIFNIEDAKQVGNID 554 Query: 265 ----------NTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 309 N + + + + ++ I+A G + ++ L+D+ N Sbjct: 555 CRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVA-GGNNNSICLYDVPN 608 >5XYI-g nrPDB Length = 335 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 54/288 (18%), Positives = 111/288 (38%), Gaps = 42/288 (14%) Query: 125 INHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEG 184 + H + + + + + LV+ + + P RL GH Sbjct: 30 VGHNAAIESIE-IDNEHNYLVSASRDKSALVWKLNRTQEQWA-----TPFTRLIGHNHFV 83 Query: 185 YGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHE 244 +S + + + LL++S D T+ LWD++ K +F GH V V + + Sbjct: 84 SDVSLSRDASH-LLTSSWDSTLRLWDLSTR-------TTKKLFLGHKKDVLGVTFSPCNR 135 Query: 245 SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP----YSEFILATGSADK 300 + SV D ++ IW+ N ++ ++ V ++ P S ++A G D Sbjct: 136 RII-SVGRDNQVKIWNILGENKAELQC-----SSWVTSVACAPMADETSPLVIAVGCWDG 189 Query: 301 TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 360 V +W + + F++H V ++P + ++ + G+DR++ +W Sbjct: 190 KVYIWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVI-TGGSDRKVVMW----------- 237 Query: 361 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 E+G + F + + + P + WI + E + VW + Sbjct: 238 -LTENGAKTISFTAP---SPVHAVAACPTQAWICAATYEG--IAVWDI 279 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 41/218 (18%), Positives = 80/218 (36%), Gaps = 38/218 (17%) Query: 221 IDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNT--SKPSHTVDAHTA 278 + F GH A +E + H + S + D+ ++W + P + H Sbjct: 23 FAPRATFVGHNAAIESIEIDNEH-NYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNH 81 Query: 279 EVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 338 V+ +S + + +L T S D T+ LWDL K F HK ++ V +SP N I+ Sbjct: 82 FVSDVSLSRDASHLL-TSSWDSTLRLWDLSTRTTK-KLFLGHKKDVLGVTFSPCNRRII- 138 Query: 339 SSGTDRRLHVWDLSKIGEEQSTED--------------------------------AEDG 366 S G D ++ +W++ + + + + Sbjct: 139 SVGRDNQVKIWNILGENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEK 198 Query: 367 PPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQ 404 +L+ H + + + P+ W+I S+ ++ Sbjct: 199 EAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVM 236 Score = 57.9 bits (138), Expect = 8e-09, Method: Composition-based stats. Identities = 20/103 (19%), Positives = 41/103 (39%), Gaps = 11/103 (10%) Query: 313 KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLF 372 +F H I ++ + L S+ D+ VW L++ E+ +T Sbjct: 25 PRATFVGHNAAIESIEID-NEHNYLVSASRDKSALVWKLNRTQEQWAT---------PFT 74 Query: 373 IHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYND 415 GH +SD S + + ++ S S D+ +++W ++ Sbjct: 75 RLIGHNHFVSDVSLSRDASHLLTS-SWDSTLRLWDLSTRTTKK 116 Score = 32.1 bits (71), Expect = 0.45, Method: Composition-based stats. Identities = 16/89 (17%), Positives = 31/89 (34%), Gaps = 6/89 (6%) Query: 128 EGEVNRARYMPQNACVIATKTPSSDVLVFDYTKH--PSKPEPSGECQPDLRLRGHQKEGY 185 V+ P A + A + V+D +P+ + R G + Sbjct: 251 PSPVHAVAACPTQAWICA--ATYEGIAVWDIGAKQQIDLVQPNFK-HEGKRNAGRTPDCT 307 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINAT 214 L+W + L S +D +I W++ + Sbjct: 308 CLAWAAD-GSVLYSGYNDGSIRAWEVKSA 335 >4AEZ-A nrPDB Length = 401 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 61/293 (20%), Positives = 111/293 (37%), Gaps = 32/293 (10%) Query: 92 SEDAQFDGSHYDNEKGEFGGFGSVCGKIEI------EIKINHEGEVNRARYMPQNACVIA 145 ++++ + S + G F G G ++I G R + N V++ Sbjct: 131 TDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWNRHVLS 190 Query: 146 TKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHT 205 + + S + D + L+GH E GL+W + L S +D+ Sbjct: 191 SGSRSGAIHHHDVRIANHQIG---------TLQGHSSEVCGLAWRSD-GLQLASGGNDNV 240 Query: 206 ICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVA--DDQKLMIWDTRN 263 + +WD R K T H A V+ VAW +L + D+++ W+ Sbjct: 241 VQIWD-------ARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWN--- 290 Query: 264 NNTSKPSHTVDAHTAEVNCLSFNPYSEFILAT-GSADKTVALWDLRNLKLKLHS-FESHK 321 T +TVDA + V L ++P+S+ I++T G D +++W + L +H Sbjct: 291 AATGARVNTVDAGSQ-VTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHD 349 Query: 322 DEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIH 374 + SP IL+++ +D L W + + P + I Sbjct: 350 TRVLYSALSPDGR-ILSTAASDENLKFWRVYDGDHVKRPIPITKTPSSSITIR 401 Score = 86.0 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 37/210 (17%), Positives = 75/210 (35%), Gaps = 30/210 (14%) Query: 204 HTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRN 263 + +W+ ++ ++ + V V W S + + I+D + Sbjct: 113 RNVYVWNADSGSVSALAETDESTY------VASVKWS-HDGSFLSVGLGNGLVDIYDVES 165 Query: 264 NNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE 323 T+ H A V CLS+N +L++GS + D+R ++ + + H E Sbjct: 166 Q---TKLRTMAGHQARVGCLSWN---RHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSE 219 Query: 324 IFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISD 383 + + W + LAS G D + +WD + + + H A + Sbjct: 220 VCGLAWR-SDGLQLASGGNDNVVQIWDARSSIPKFTKTN--------------HNAAVKA 264 Query: 384 FSWNPNEPWIICSVS--EDNIMQVWQMAEN 411 +W P + ++ + D + W A Sbjct: 265 VAWCPWQSNLLATGGGTMDKQIHFWNAATG 294 Score = 70.2 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 28/166 (16%), Positives = 69/166 (41%), Gaps = 21/166 (12%) Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 +VA ++ + +W+ + + S + T + + V + ++ F L+ G + V ++D Sbjct: 106 VVAVALERNVYVWNADSGSVSALAETDE--STYVASVKWSHDGSF-LSVGLGNGLVDIYD 162 Query: 307 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 366 + + KL + H+ + + W N +L+S +H D+ Sbjct: 163 VESQT-KLRTMAGHQARVGCLSW---NRHVLSSGSRSGAIHHHDVR-------------I 205 Query: 367 PPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENV 412 + GH++++ +W + + S DN++Q+W ++ Sbjct: 206 ANHQIGTLQGHSSEVCGLAWRSDGLQL-ASGGNDNVVQIWDARSSI 250 >5I2T-A nrPDB Length = 742 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 53/253 (20%), Positives = 103/253 (40%), Gaps = 22/253 (8%) Query: 137 MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPD---LRLRGHQKEGYGLSWNPNL 193 M QN + + + L F +K E Q + L+ +GH L+++P+ Sbjct: 325 MGQNPVNTVSVNQTGEWLAFGSSKLGQLL--VYEWQSESYILKQQGHFDSTNSLAYSPD- 381 Query: 194 NGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADD 253 +++AS+D I +WDI + F HT+ V V + + +F S + D Sbjct: 382 GSRVVTASEDGKIKVWDITSG-------FCLATFEEHTSSVTAVQFAKRGQVMF-SSSLD 433 Query: 254 QKLMIWDTRNNNTSKPSHTVDAHTA-EVNCLSFNPYSEFILATGSADK-TVALWDLRNLK 311 + WD + T + NCL+ +P E ++ GS D + +W ++ + Sbjct: 434 GTVRAWDL---IRYRNFRTFTGTERIQFNCLAVDPSGE-VVCAGSLDNFDIHVWSVQTGQ 489 Query: 312 LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELL 371 L L + H+ + + +S N ++LAS+ D+ + +W + ++ + L Sbjct: 490 L-LDALSGHEGPVSCLSFSQEN-SVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALS 547 Query: 372 FIHGGHTAKISDF 384 G +S Sbjct: 548 MRPDGKEVAVSTL 560 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 61/376 (16%), Positives = 127/376 (33%), Gaps = 63/376 (16%) Query: 92 SEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSS 151 S+D++F + + + S + H V + + I T + Sbjct: 180 SQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMG-AFFSHDQEKIYTVSKDG 238 Query: 152 DVLVFDYTKHPS-----------KPEPSGECQPDLRLR------GHQKEGYGLSWNPNLN 194 V V+++TK PS K E + R+ +Q + ++++P Sbjct: 239 AVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPAT- 297 Query: 195 GYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQ 254 L L+D+ + V V+ + E L + Sbjct: 298 RLLAVGFTSGEFRLYDLPD-------FTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLG 350 Query: 255 KLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL 314 +L++++ ++ + H N L+++P ++ T S D + +WD+ + L Sbjct: 351 QLLVYEWQSESY---ILKQQGHFDSTNSLAYSPDGSRVV-TASEDGKIKVWDITSG-FCL 405 Query: 315 HSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFI- 373 +FE H + VQ++ + ++ SS D + WDL + ++ E L + Sbjct: 406 ATFEEHTSSVTAVQFAKRGQ-VMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVD 464 Query: 374 -----------------------------HGGHTAKISDFSWNPNEPWIICSVSEDNIMQ 404 GH +S S++ E ++ S S D ++ Sbjct: 465 PSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QENSVLASASWDKTIR 523 Query: 405 VWQMAENVYNDEEPEI 420 +W + E E+ Sbjct: 524 IWSIFGRSQQVEPIEV 539 Score = 101 bits (251), Expect = 6e-22, Method: Composition-based stats. Identities = 42/303 (13%), Positives = 98/303 (32%), Gaps = 50/303 (16%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H ++ + Q++ I T + ++ + GH+ Sbjct: 169 GHFQDITSLTW-SQDSRFILTTSKDLSAKIWSVDSEEKNLAAT-------TFNGHRDYVM 220 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRV--------------------IDAKN 225 G ++ + + + S D + +W+ P + I K+ Sbjct: 221 G-AFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKH 279 Query: 226 IFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSF 285 F + A V+ V +H L + ++D + + VN +S Sbjct: 280 FFYANQAKVKCVTFHP-ATRLLAVGFTSGEFRLYDLPD---FTLIQQLSMGQNPVNTVSV 335 Query: 286 NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRR 345 N E++ S + +++ ++ L + H D + +SP ++ ++ D + Sbjct: 336 NQTGEWLAFGSSKLGQLLVYEWQSESYILKQ-QGHFDSTNSLAYSPDGSRVV-TASEDGK 393 Query: 346 LHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQV 405 + VWD++ L HT+ ++ + + S S D ++ Sbjct: 394 IKVWDITSG--------------FCLATFEEHTSSVTAVQFAKRGQVMF-SSSLDGTVRA 438 Query: 406 WQM 408 W + Sbjct: 439 WDL 441 Score = 90.6 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 39/288 (13%), Positives = 91/288 (31%), Gaps = 63/288 (21%) Query: 181 QKEGYGLSWNPNLNGYLLSASDDHTICLWDIN--ATPKEHRVIDAKNIFTGHTAVVEDVA 238 +++ + ++P+ + L++ + +W ++ + GH + + Sbjct: 121 KEKCSAVKFSPDGRLFALASG--RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLT 178 Query: 239 WHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSA 298 W + + + D IW + + + T + H V F+ E I T S Sbjct: 179 WSQDSRFILTT-SKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIY-TVSK 236 Query: 299 DKTVALW-----------------------DLRNLKLKL---HSFESHKDEIFQVQWSPH 332 D V +W D+ ++ H F +++ ++ V + P Sbjct: 237 DGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPA 296 Query: 333 NETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPP------------------------ 368 +LA T ++DL Q ++ Sbjct: 297 TR-LLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVY 355 Query: 369 -----ELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 + GH + +++P+ ++ + SED ++VW + Sbjct: 356 EWQSESYILKQQGHFDSTNSLAYSPDGSRVV-TASEDGKIKVWDITSG 402 Score = 68.7 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 35/225 (15%), Positives = 82/225 (36%), Gaps = 32/225 (14%) Query: 198 LSASDDHTICLWDINATPKEHRVIDAKN-IFT-GHTAVVEDVAWHLLHESLFGSVADDQK 255 ++ SDD L + +I+ K+ F H + + + L S+ +D + Sbjct: 45 ITFSDDGKQLLSPVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGT-LLISIDEDGR 103 Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI-LATGSADKTVALWDLRNLK--- 311 ++ + + N + + + + + F+P LA+G + +W ++ Sbjct: 104 AILVNFKARNVLHHFNFKE----KCSAVKFSPDGRLFALASGRF---LQIWKTPDVNKDR 156 Query: 312 -----LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 366 ++ H +I + WS + IL +S D +W + + + Sbjct: 157 QFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTS-KDLSAKIWSVDSEEKNLAA------ 209 Query: 367 PPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 GH + ++ ++ I +VS+D + VW+ + Sbjct: 210 -----TTFNGHRDYVMGAFFSHDQEK-IYTVSKDGAVFVWEFTKR 248 Score = 59.4 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 36/235 (15%), Positives = 76/235 (32%), Gaps = 62/235 (26%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPS---------------KPEPSGE 170 H V ++ + V+ + + V +D ++ + +PSGE Sbjct: 410 EHTSSVTAVQF-AKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGE 468 Query: 171 -------------------CQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDI 211 Q L GH+ LS++ N L SAS D TI +W I Sbjct: 469 VVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QENSVLASASWDKTIRIWSI 527 Query: 212 NATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNN------- 264 ++ I+ + V ++ + + S ++ I++ + Sbjct: 528 FGRSQQVEPIEVY-------SDVLALSMRPDGKEVAVS-TLKGQISIFNIEDAKQVGNID 579 Query: 265 ----------NTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 309 N + + + + ++ I+A G + ++ L+D+ N Sbjct: 580 CRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVA-GGNNNSICLYDVPN 633 >5FA5-B nrPDB Length = 367 Score = 126 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 47/224 (20%), Positives = 93/224 (41%), Gaps = 21/224 (9%) Query: 123 IKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQK 182 K H+ V+ + + + + V+D + R H Sbjct: 145 CKYEHDDIVSTVSVLSS-GTQAVSGSKDICIKVWDLAQQVVLSS----------YRAHAA 193 Query: 183 EGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLL 242 + ++ +P+ + LS S+D+ I LWD PK I + + +AWH Sbjct: 194 QVTCVAASPHKDSVFLSCSEDNRILLWDTRC-PKPASQIGC----SAPGYLPTSLAWHPQ 248 Query: 243 HESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTV 302 +F ++ + + DT++ + + H+ V L F+P+S LA+ S D ++ Sbjct: 249 QSEVFVFGDENGTVSLVDTKSTS---CVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSL 305 Query: 303 ALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 346 A+ D + +L ++H+D + WSP N ++L + G D ++ Sbjct: 306 AVLD--SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 56/278 (20%), Positives = 108/278 (38%), Gaps = 37/278 (13%) Query: 128 EGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGL 187 E V ++ + ++A+ + V +++ ++ + H + Sbjct: 105 EAGVADLTWVGERGILVASDS--GAVELWELDENETLIVSKFCKYE------HDDIVSTV 156 Query: 188 SWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLF 247 S + +S S D I +WD+ + + H A V VA +S+F Sbjct: 157 SVL-SSGTQAVSGSKDICIKVWDLAQQV-------VLSSYRAHAAQVTCVAASPHKDSVF 208 Query: 248 GSVADDQKLMIWDTRNNNTSKPSHTVD-AHTAEV-NCLSFNPYSEFILATGSADKTVALW 305 S ++D ++++WDTR KP+ + + + L+++P + G + TV+L Sbjct: 209 LSCSEDNRILLWDTR---CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 265 Query: 306 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED 365 D ++ L S H + + +SPH+ LAS D L V D S Sbjct: 266 DTKSTSCVLSS-AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSS------------- 311 Query: 366 GPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIM 403 LF H + D +W+P ++ +V D+ + Sbjct: 312 --LSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 91.4 bits (225), Expect = 6e-19, Method: Composition-based stats. Identities = 50/284 (17%), Positives = 94/284 (33%), Gaps = 29/284 (10%) Query: 127 HEGEVNRARYMPQNACVIATKTPSSDVLVFDY--TKHPSKPEPSGECQPDLRLRGHQKEG 184 E ++ ARY A ++ + S K P G C ++ Sbjct: 52 MERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEA---GV 108 Query: 185 YGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHE 244 L+W +L ASD + LW+++ K H +V V+ Sbjct: 109 ADLTWVGERG--ILVASDSGAVELWELDENETLIVSKFCK---YEHDDIVSTVSVLSSGT 163 Query: 245 SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 304 S + D + +WD + AH A+V C++ +P+ + + + S D + L Sbjct: 164 QAV-SGSKDICIKVWDLAQQVV---LSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILL 219 Query: 305 WDLRNLKLKLHSFESHKDEI-FQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDA 363 WD R K S + + W P + + + + D Sbjct: 220 WDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTS-------- 271 Query: 364 EDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 + H+ ++ ++P+ + S+SED + V Sbjct: 272 ------CVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 309 Score = 61.3 bits (147), Expect = 7e-10, Method: Composition-based stats. Identities = 28/179 (15%), Positives = 53/179 (29%), Gaps = 43/179 (24%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTK---------------------HPSK 164 H +V P V + + + +L++D HP + Sbjct: 190 AHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQ 249 Query: 165 PEPSGECQPDLRLR--------------GHQKEGYGLSWNPNLNGYLLSASDDHTICLWD 210 E + + H + GL ++P+ +L S S+D ++ + D Sbjct: 250 SEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 309 Query: 211 INATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKP 269 + H V D W L+ SL +V D +++ P Sbjct: 310 --------SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAP 360 Score = 32.5 bits (72), Expect = 0.34, Method: Composition-based stats. Identities = 17/93 (18%), Positives = 34/93 (36%), Gaps = 13/93 (13%) Query: 321 KDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAK 380 + + + W ++AS + +W+L D + F H Sbjct: 105 EAGVADLTWVGERGILVASDS--GAVELWEL----------DENETLIVSKFCKYEHDDI 152 Query: 381 ISDFSWNPNEPWIICSVSEDNIMQVWQMAENVY 413 +S S + + S S+D ++VW +A+ V Sbjct: 153 VSTVSVLSSGTQAV-SGSKDICIKVWDLAQQVV 184 >6BX3-A nrPDB Length = 314 Score = 124 bits (312), Expect = 6e-29, Method: Composition-based stats. Identities = 57/271 (21%), Positives = 104/271 (38%), Gaps = 28/271 (10%) Query: 145 ATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDH 204 A +P L + + + + H + L W+P+ + +ASDD Sbjct: 18 AKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPD-GQCIATASDDF 76 Query: 205 TICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNN 264 ++ + H + F GHTA V + ++ LF S + D+ + IWDT N Sbjct: 77 SVEI--------IHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTS-SMDESIKIWDTLNG 127 Query: 265 NTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE- 323 + K T+ AH+ V + IL++GS D + ++D L + KD Sbjct: 128 SLMK---TISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHC-LKTLTYDKDWK 183 Query: 324 -------IFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGG 376 I QV++S + +L S D + +WD ++ + P E +H Sbjct: 184 RENGVVPISQVKFSENARYLLVKS-LDGVVKIWDCIGGCVVRTFQVQ---PLEKGVLH-- 237 Query: 377 HTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 H+ + + ++ S E+ + W Sbjct: 238 HSCGMDFLNPEDGSTPLVISGYENGDIYCWN 268 Score = 101 bits (250), Expect = 8e-22, Method: Composition-based stats. Identities = 43/224 (19%), Positives = 87/224 (38%), Gaps = 22/224 (9%) Query: 185 YGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHE 244 +P+ ++ I ++DIN R ++ + T H ++ W Sbjct: 16 TCAKISPDGQFLAITQG--LNILIYDIN------RRTVSQTLVTSHARPFSELCWSPDG- 66 Query: 245 SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 304 + +DD + I HT HTA V L+FN + T S D+++ + Sbjct: 67 QCIATASDDFSVEIIHLSYG----LLHTFIGHTAPVISLTFNRKGNLLF-TSSMDESIKI 121 Query: 305 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAE 364 WD N L + +H + + V ++ +IL+S D + ++D ++ + Sbjct: 122 WDTLNGSLM-KTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDK 180 Query: 365 DGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 D E + IS ++ N +++ S D ++++W Sbjct: 181 DWKRENGVVP------ISQVKFSENARYLLVK-SLDGVVKIWDC 217 Score = 77.1 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 32/238 (13%), Positives = 67/238 (28%), Gaps = 27/238 (11%) Query: 125 INHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEG 184 I H V + + ++ T + + ++D + H + Sbjct: 92 IGHTAPVISLTFN-RKGNLLFTSSMDESIKIWDTLNGSLMK----------TISAHSEAV 140 Query: 185 YGLSWNPNLNGYLLSASDDHTICLWDINATPKEHR-VIDAKNIFTGHTAVVEDVAWHLLH 243 + N + L S S D I ++D D + V + Sbjct: 141 VSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENA 200 Query: 244 ESLFGSVADDQKLMIWDTRNNNTSKPSHT------VDAHTAEVNCLSFNPYSEFILATGS 297 L + D + IWD + V H+ ++ L+ S ++ +G Sbjct: 201 RYLLV-KSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGY 259 Query: 298 ADKTVALWDLRNLKLKLHSFES----HKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 + + W+ L L + H + + I+ S + +W Sbjct: 260 ENGDIYCWNSDTKSL-LQLLDGSLYHHSSPVMSIHCF---GNIMCSLALNGDCCLWRW 313 Score = 74.4 bits (181), Expect = 8e-14, Method: Composition-based stats. Identities = 30/177 (16%), Positives = 64/177 (36%), Gaps = 22/177 (12%) Query: 235 EDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILA 294 + L + + ++I+D S+ T +H + L ++P + I A Sbjct: 16 TCAKISPDGQFLAITQGLN--ILIYDINRRTVSQTLVT--SHARPFSELCWSPDGQCI-A 70 Query: 295 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKI 354 T S D +V + L LH+F H + + ++ +L +S D + +WD Sbjct: 71 TASDDFSVEIIHLSYG--LLHTFIGHTAPVISLTFNRKG-NLLFTSSMDESIKIWDTLNG 127 Query: 355 GEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 ++ H+ + N+ I+ S S D +++++ Sbjct: 128 SLMKTI--------------SAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG 170 >1NR0-A nrPDB Length = 611 Score = 124 bits (310), Expect = 9e-29, Method: Composition-based stats. Identities = 49/247 (19%), Positives = 97/247 (39%), Gaps = 24/247 (9%) Query: 167 PSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNI 226 P G H + +P Y S + +WD T H + + Sbjct: 45 PVGSLTDTEIYTEHSHQTTVAKTSP-SGYYCASGDVHGNVRIWD--TTQTTHILKTTIPV 101 Query: 227 FTGHTAVVEDVAWHLLHESLFGSVA---DDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCL 283 F+G V+D++W + + + ++DT +N + + +N + Sbjct: 102 FSG---PVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGN-----LTGQARAMNSV 153 Query: 284 SFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTD 343 F P F + +GS D TVA+++ K K +F H + V+++P ++ AS+G D Sbjct: 154 DFKPSRPFRIISGSDDNTVAIFEGPPFKFK-STFGEHTKFVHSVRYNPDG-SLFASTGGD 211 Query: 344 RRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIM 403 + +++ + ED + H+ + +W+P+ I S S D + Sbjct: 212 GTIVLYNGVDGTKTGVFEDDS-------LKNVAHSGSVFGLTWSPDGTK-IASASADKTI 263 Query: 404 QVWQMAE 410 ++W +A Sbjct: 264 KIWNVAT 270 Score = 97.9 bits (242), Expect = 7e-21, Method: Composition-based stats. Identities = 51/350 (14%), Positives = 112/350 (32%), Gaps = 63/350 (18%) Query: 112 FGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGEC 171 + G + + A+ +V ++D T+ + + Sbjct: 42 YTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPV 101 Query: 172 QPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHT----ICLWDINATPKEHRVIDAKNIF 227 +SW+ + + + + + + L+D + Sbjct: 102 F--------SGPVKDISWD-SESKRIAAVGEGRERFGHVFLFDTGTSNGN---------L 143 Query: 228 TGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP 287 TG + V + S +DD + I+ K T HT V+ + +NP Sbjct: 144 TGQARAMNSVDFKPSRPFRIISGSDDNTVAIF---EGPPFKFKSTFGEHTKFVHSVRYNP 200 Query: 288 YSEFILATGSADKTVALWD----LRNLKLKLHSFE--SHKDEIFQVQWSPHNETILASSG 341 +TG D T+ L++ + + S + +H +F + WSP T +AS+ Sbjct: 201 DGSLFASTGG-DGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG-TKIASAS 258 Query: 342 TDRRLHVWDLSKIGEEQSTEDAEDGPPELLFI---------------------------- 373 D+ + +W+++ + E++ + L I Sbjct: 259 ADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQ 318 Query: 374 -HGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPA 422 GH I+ S + + + S + + W ++ + N P++ A Sbjct: 319 VRYGHNKAITALSSSADGKTLF-SADAEGHINSWDISTGISNRVFPDVHA 367 Score = 77.5 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 50/261 (19%), Positives = 96/261 (36%), Gaps = 34/261 (13%) Query: 112 FGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTP--SSDVLVFDYTKHPSKPEPSG 169 F V + IK +G++ + V A + SS + + P S Sbjct: 362 FPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSA 421 Query: 170 E-------CQPDLRLRGHQK--------EGYGLSWNPNLNGYLLSASDDHTICLWDINAT 214 + C + + H K ++ + N ++ D + ++ ++ Sbjct: 422 DGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALS-NDKQFVAVGGQDSKVHVYKLSGA 480 Query: 215 PKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMI--WDTRNNNTSKPSHT 272 H A + VA+ L + DQ + + NN +++ Sbjct: 481 SVSEVKTIV------HPAEITSVAFSNNGAFLVAT---DQSRKVIPYSVANNFELAHTNS 531 Query: 273 VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL-KLHSFESHK-DEIFQVQWS 330 HTA+V C+S++P + LATGS D +V +W++ + +H + V W Sbjct: 532 WTFHTAKVACVSWSPDNVR-LATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW- 589 Query: 331 PHNETILASSGTDRRLHVWDL 351 NET + S+G D + W++ Sbjct: 590 -LNETTIVSAGQDSNIKFWNV 609 Score = 75.6 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 60/356 (16%), Positives = 112/356 (31%), Gaps = 94/356 (26%) Query: 125 INHEGEVNRARYMPQNACVIATKTPSSDVLVFDY-TKHPSKPEPSGECQPDLRL------ 177 + H G V + P + IA+ + + +++ T K P G D +L Sbjct: 236 VAHSGSVFGLTWSP-DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK 294 Query: 178 --------------------------RGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDI 211 GH K LS + + L SA + I WDI Sbjct: 295 QALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSAD-GKTLFSADAEGHINSWDI 353 Query: 212 NATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIW-----------D 260 + D H ++ + + +V+ D L + Sbjct: 354 STGISNRVFPDV------HATMITGIK--TTSKGDLFTVSWDDHLKVVPAGGSGVDSSKA 405 Query: 261 TRNNNTSKPSHTVDAHTAEV--------------------------NCLSFNPYSEFILA 294 N +S+P + ++ +C++ + +F +A Sbjct: 406 VANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQF-VA 464 Query: 295 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKI 354 G D V ++ L + H EI V +S + ++A+ + + + Sbjct: 465 VGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVI------PY 518 Query: 355 GEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 410 + E A HTAK++ SW+P+ + + S DN + VW M + Sbjct: 519 SVANNFELAHTNSWTF------HTAKVACVSWSPDN-VRLATGSLDNSVIVWNMNK 567 Score = 73.7 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 34/223 (15%), Positives = 79/223 (35%), Gaps = 18/223 (8%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H V+ RY P + + A+ +++++ + L+ H + Sbjct: 188 EHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDD---SLKNVAHSGSVF 243 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 GL+W+P+ + SAS D TI +W++ E + I ++ + Sbjct: 244 GLTWSPD-GTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGII-------WTKQ 295 Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 305 S++ + + + + + + H + LS + + + + A+ + W Sbjct: 296 ALVSISANGFINFVNPELGSIDQVRY---GHNKAITALSSSADGKTLF-SADAEGHINSW 351 Query: 306 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHV 348 D+ + H I ++ + + L + D L V Sbjct: 352 DISTGISNRVFPDVHATMITGIKTTSKGD--LFTVSWDDHLKV 392 Score = 68.7 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 36/179 (20%), Positives = 72/179 (40%), Gaps = 26/179 (14%) Query: 235 EDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILA 294 VA + D K+ ++ + S+ V H AE+ ++F+ F++A Sbjct: 452 SCVALS-NDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV--HPAEITSVAFSNNGAFLVA 508 Query: 295 TGSADKTVAL--WDLRNLKLKLHS--FESHKDEIFQVQWSPHNETILASSGTDRRLHVWD 350 T D++ + + + N H+ + H ++ V WSP N LA+ D + VW+ Sbjct: 509 T---DQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVR-LATGSLDNSVIVWN 564 Query: 351 LSKIGEEQSTEDAEDGPPELLFIHGGH-TAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 ++K + + I G H + ++ W I S +D+ ++ W + Sbjct: 565 MNKPSDH------------PIIIKGAHAMSSVNSVIWL--NETTIVSAGQDSNIKFWNV 609 Score = 64.8 bits (156), Expect = 7e-11, Method: Composition-based stats. Identities = 31/168 (18%), Positives = 60/168 (35%), Gaps = 25/168 (14%) Query: 104 NEKGEFGGFGSVCGKIEI----------EIKINHEGEVNRARYMPQNACVIATKTPSSDV 153 + +F G K+ + I H E+ + A ++AT S V Sbjct: 457 SNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVAT-DQSRKV 515 Query: 154 LVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINA 213 + + + E H + +SW+P+ N L + S D+++ +W++N Sbjct: 516 IPYSVAN-------NFELAHTNSWTFHTAKVACVSWSPD-NVRLATGSLDNSVIVWNMNK 567 Query: 214 TPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDT 261 +I + + V V W L+E+ S D + W+ Sbjct: 568 PSDHPIIIKGAHAMSS----VNSVIW--LNETTIVSAGQDSNIKFWNV 609 >6J6H-n nrPDB Length = 455 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 43/228 (18%), Positives = 88/228 (38%), Gaps = 28/228 (12%) Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 GH + L + P +LS +DHTI +WD + + F GH ++ + Sbjct: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF------YHDYECLRDFQGHNKPIKALR 213 Query: 239 WHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSA 298 + +S F S + D+ + IWDT H +++ A+V P + G + Sbjct: 214 FTEDCQS-FLSSSFDRSVKIWDTETGKVKTRLH-LNSTPADVESR---PTNPHEFIVGLS 268 Query: 299 DKTVALWDLR--NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGE 356 + + +D R + + +++ H I +++ P + SS D+ + +W+ Sbjct: 269 NSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFI-SSSEDKTVRIWE------ 321 Query: 357 EQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQ 404 + I + + +P++ C+ S DN + Sbjct: 322 -------NQINVPIKQISDTAQHSMPFLNVHPSQ-NYFCAQSMDNRIY 361 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 47/285 (16%), Positives = 100/285 (35%), Gaps = 36/285 (12%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H +++P+ +I + + ++D+ EC +GH K Sbjct: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD-------YEC--LRDFQGHNKPIK 210 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGH-TAVVEDVAWHLLHE 244 L + + +L S+S D ++ +WD + R+ H + DV + Sbjct: 211 ALRFTEDCQSFL-SSSFDRSVKIWDTETGKVKTRL---------HLNSTPADVESRPTNP 260 Query: 245 SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 304 F + K++ +D R + T D H + + L + P +++ S DKTV + Sbjct: 261 HEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISS-SEDKTVRI 319 Query: 305 WD--LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTED 362 W+ + ++ H V S + + D R++ + L + Sbjct: 320 WENQINVPIKQISDTAQHSMPFLNVHPSQN---YFCAQSMDNRIYSFSLKPKYKRH---- 372 Query: 363 AEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 P+ +F +++ + + ICS + + W Sbjct: 373 -----PKKIFKGHSSAGYGISLAFSGDGRY-ICSGDSKSRLFTWD 411 Score = 89.1 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 37/211 (17%), Positives = 73/211 (34%), Gaps = 19/211 (9%) Query: 216 KEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDA 275 + + + GH + + L S +D + IWD + + Sbjct: 147 RCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF--YHDYECLRDFQG 204 Query: 276 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEI-FQVQWSPHNE 334 H + L F + L++ S D++V +WD K+K H + V+ P N Sbjct: 205 HNKPIKALRFTEDCQSFLSS-SFDRSVKIWDTETGKVKTRL---HLNSTPADVESRPTNP 260 Query: 335 TILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWII 394 ++ ++ +D D L+ + H + I + P+ I Sbjct: 261 HEFIVGLSNSKILHYD-----------DRVSENQGLVQTYDHHLSSILALKYFPDGSKFI 309 Query: 395 CSVSEDNIMQVWQMAENVYNDEEPEIPASEL 425 S SED +++W+ NV + + + Sbjct: 310 -SSSEDKTVRIWENQINVPIKQISDTAQHSM 339 Score = 49.0 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 27/181 (14%), Positives = 66/181 (36%), Gaps = 16/181 (8%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 +H + +Y P + I++ + V +++ + + S Q + Sbjct: 291 HHLSSILALKYFPDGSKFISS-SEDKTVRIWENQINVPIKQISDTAQHSMPF-------- 341 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 L+ +P+ N Y + S D+ I + + K H K IF GH++ ++ + Sbjct: 342 -LNVHPSQN-YFCAQSMDNRIYSFSLKPKYKRH----PKKIFKGHSSAGYGISLAFSGDG 395 Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 305 + + D K ++ N + ++ + + ++P + A + + Sbjct: 396 RYI-CSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 Query: 306 D 306 D Sbjct: 455 D 455 Score = 37.8 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 10/62 (16%), Positives = 24/62 (38%) Query: 350 DLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMA 409 D+ E+ P +++ + GH + + P +I S D+ +++W Sbjct: 134 DVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFY 193 Query: 410 EN 411 + Sbjct: 194 HD 195 >2AQ5-A nrPDB Length = 402 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 52/281 (18%), Positives = 97/281 (34%), Gaps = 22/281 (7%) Query: 112 FGSVCGKIEIEIKINHEGEVNRARYMPQNACVIA-----TKTPSSDVLVFDYTKHPSKPE 166 FG + + + + N +A + + VL T K Sbjct: 15 FGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFMALICEASGGGAFLVLPLGKTGRVDKNV 74 Query: 167 PSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNI 226 P + GH ++W P+ + + S S+D T+ +W+I + + Sbjct: 75 PL--------VCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVIT 126 Query: 227 FTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFN 286 GHT V VAWH +++ S D +++WD + D H + + ++ Sbjct: 127 LEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAV-LTLGPDVHPDTIYSVDWS 185 Query: 287 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKD--EIFQVQWSPHNETILASSGTD- 343 I T DK V + + R + H+ + V S IL + + Sbjct: 186 RDGALI-CTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVS--EGKILTTGFSRM 242 Query: 344 --RRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKIS 382 R++ +WD + E S ++ + LL T + Sbjct: 243 SERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVY 283 Score = 85.2 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 22/93 (23%), Positives = 40/93 (43%), Gaps = 7/93 (7%) Query: 319 SHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHT 378 H + + W PHN+ ++AS D + VW++ G E + GHT Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLR-------EPVITLEGHT 131 Query: 379 AKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 ++ +W+P ++ S DN++ VW + Sbjct: 132 KRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTG 164 >5WLC-LU nrPDB Length = 489 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 57/342 (16%), Positives = 111/342 (32%), Gaps = 88/342 (25%) Query: 125 INHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEG 184 H V + +AT + + ++ + + + + H Sbjct: 64 YGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMS----------TREEFVSFKAHYGLV 113 Query: 185 YGLSWNP----------NLNGYLLSASDDHTICLWDIN----------------ATPKEH 218 GL ++LS SDD T+ LW IN Sbjct: 114 TGLCVTQPRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLI 173 Query: 219 RVIDAKNIFTG---HT--------------------AVVEDVAW----------HLLHES 245 R D ++ F G H V D++W + Sbjct: 174 RTFDGESAFQGIDSHRENSTFATGGAKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETD 233 Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 305 + S D ++++D R N+ P+ + T N + +NP F T + D + Sbjct: 234 ILASTGSDNSIVLYDLRTNS---PTQKIV-QTMRTNAICWNPMEAFNFVTANEDHNAYYY 289 Query: 306 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED 365 D+RNL L+ F+ H + V +SP + I+ + D+ + ++ + + Sbjct: 290 DMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIV-TGSYDKSIRIYKTNHGHSRE------- 341 Query: 366 GPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 H + ++ + +II S S+D +++W+ Sbjct: 342 ------IYHTKRMQHVFQVKYSMDSKYII-SGSDDGNVRLWR 376 Score = 95.2 bits (235), Expect = 5e-20, Method: Composition-based stats. Identities = 50/286 (17%), Positives = 96/286 (33%), Gaps = 66/286 (23%) Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 GH+ Y ++ N L + S D I W+++ + F H +V + Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREE-------FVSFKAHYGLVTGLC 117 Query: 239 WHLL----------HESLFGSVADDQKLMIW-----DTRNNNTSK---------PSHTVD 274 ++ S +DD+ + +W D N N+S T D Sbjct: 118 VTQPRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFD 177 Query: 275 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE 334 +A + + + ATG A + LWD+ LK + D I ++++ + Sbjct: 178 GESAF-QGIDSHRENS-TFATGGA--KIHLWDVNRLK-PVSDLSWGADNITSLKFNQNET 232 Query: 335 TILASSGTDRRLHVWDLSKIGEEQSTEDA-----------------------------ED 365 ILAS+G+D + ++DL Q Sbjct: 233 DILASTGSDNSIVLYDLRTNSPTQKIVQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMR 292 Query: 366 GPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 L + H + + D ++P I+ + S D +++++ Sbjct: 293 NLSRSLNVFKDHVSAVMDVDFSPTGDEIV-TGSYDKSIRIYKTNHG 337 Score = 48.2 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 17/95 (17%), Positives = 35/95 (36%), Gaps = 4/95 (4%) Query: 319 SHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHT 378 H+D ++ + + + LA+ D + W++S E S + L Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFH 124 Query: 379 AKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVY 413 K D + S S+D +++W + + Y Sbjct: 125 DKKPDL----KSQNFMLSCSDDKTVKLWSINVDDY 155 >5FVM-C nrPDB Length = 303 Score = 121 bits (303), Expect = 7e-28, Method: Composition-based stats. Identities = 42/251 (16%), Positives = 92/251 (36%), Gaps = 25/251 (9%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H+G V + +N ++++ + + V+D R H Sbjct: 73 GHKGNVTSIAFQQENRWMVSS-SEDGTIKVWDVRSP-----------SVQRNYKHNAPVN 120 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 ++ +PN L+S D I +WD+ +++ N +V D S Sbjct: 121 EVAIHPNQGE-LISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASD-------GS 172 Query: 246 LFGSVADDQKLMIWDTR---NNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTV 302 + + + +W + +T +P +HT + + + + LAT SAD T Sbjct: 173 MLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKN-LATCSADHTA 231 Query: 303 ALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTED 362 +W++ + + + H+ ++ +S + L ++ +D + +WDLS + Sbjct: 232 RVWNIEDNYQLETTLDGHQRWVWDCAFS-ADSAYLVTACSDHYVRLWDLSTSEIVRQYGG 290 Query: 363 AEDGPPELLFI 373 G + Sbjct: 291 HHKGAVCVALN 301 Score = 112 bits (279), Expect = 4e-25, Method: Composition-based stats. Identities = 46/275 (16%), Positives = 98/275 (35%), Gaps = 55/275 (20%) Query: 196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 255 L SA DHTI W+ T R I + + D + + A Sbjct: 4 ILASAGYDHTIRFWE-ALTGVCSRTIQHADSQVNRLEITSD--------KKYLAAAGHLH 54 Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 315 + ++D R+NN P + + H V ++F + +++++ S D T+ +WD+R+ ++ + Sbjct: 55 VRLYDIRSNN-PNPVSSFEGHKGNVTSIAFQQENRWMVSS-SEDGTIKVWDVRSPSVQRN 112 Query: 316 SFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHG 375 H + +V P+ ++ S D + +WDL + ++ P + L + Sbjct: 113 --YKHNAPVNEVAIHPNQGELI-SCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVAS 169 Query: 376 G-----------------------------------HTAKISDFSWNPNEPWIICSVSED 400 HT I+ + + + + S D Sbjct: 170 DGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNL-ATCSAD 228 Query: 401 NIMQVWQMAEN-----VYNDEEPEIPASELETNTA 430 + +VW + +N + + + ++A Sbjct: 229 HTARVWNIEDNYQLETTLDGHQRWVWDCAFSADSA 263 >6CHG-A nrPDB Length = 312 Score = 119 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 50/290 (17%), Positives = 107/290 (36%), Gaps = 33/290 (11%) Query: 133 RARYMPQNACVIATK--TPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWN 190 + +P + + + +P +++ E S L H++ L W+ Sbjct: 5 DKQVLPASGKISTSCQISPDGELIAICQNTDMLVYEISSSKMMKLTTT-HKECINCLCWS 63 Query: 191 PNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSV 250 P+ + + S S+D T+ + H + GHTA V + ++ ++ S Sbjct: 64 PD-SKCIASGSEDFTVEI--------THIIYGRIRRLMGHTAPVISICYNNKG-NILCSS 113 Query: 251 ADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 310 + D+ + W + K T+ AH+ V + + IL++GS D + ++D + Sbjct: 114 SMDESIKEWHVLSGTALK---TMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESG 170 Query: 311 KLKLHSFESHKDE--------IFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTED 362 L + KD I V++S + + +L S D + +W+ ++ ++ Sbjct: 171 HC-LKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKS-LDNVVKLWEYTRGTVVRTFLW 228 Query: 363 AEDGPPELLFIHGGHTAKISDFSWNPNEPW-IICSVSEDNIMQVWQMAEN 411 L + G P ++ S ++ M VW + Sbjct: 229 PHQETKAKLKYNCGLEL------IYPQGKDPLVISGNDSGSMCVWNVYSK 272 Score = 96.8 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 32/184 (17%), Positives = 71/184 (38%), Gaps = 14/184 (7%) Query: 230 HTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS 289 H + + W S ++D + I + + HTA V + +N Sbjct: 53 HKECINCLCWSP-DSKCIASGSEDFTVEI----THIIYGRIRRLMGHTAPVISICYN-NK 106 Query: 290 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 IL + S D+++ W + + L + +H D + + + +IL+S D + ++ Sbjct: 107 GNILCSSSMDESIKEWHVLSGT-ALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIF 165 Query: 350 DLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMA 409 D ++ +D E + IS ++ N +++ S DN++++W+ Sbjct: 166 DTESGHCLKTLTYDKDWIAEDGVVP------ISTVKFSRNGKFLLVK-SLDNVVKLWEYT 218 Query: 410 ENVY 413 Sbjct: 219 RGTV 222 Score = 64.4 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 32/254 (12%), Positives = 73/254 (28%), Gaps = 29/254 (11%) Query: 98 DGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFD 157 D + +F + I + H V Y ++ + + + + Sbjct: 65 DSKCIASGSEDFTVEITHIIYGRIRRLMGHTAPVISICYN-NKGNILCSSSMDESIKEWH 123 Query: 158 YTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKE 217 + + H + + L S S D I ++D + Sbjct: 124 VLSGTALK----------TMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCL 173 Query: 218 HR-VIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSK----PSHT 272 D I + V + + L + D + +W+ + P Sbjct: 174 KTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVK-SLDNVVKLWEYTRGTVVRTFLWPHQE 232 Query: 273 VDAHTAEVNCLS--FNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWS 330 A L + + ++ +G+ ++ +W++ + L E H++ S Sbjct: 233 TKAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEKHRN-------S 285 Query: 331 PHNETILASSGTDR 344 P I S+ D+ Sbjct: 286 P---LISISASYDK 296 Score = 52.1 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 28/132 (21%), Positives = 50/132 (37%), Gaps = 20/132 (15%) Query: 281 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 340 +P E I + D V +++ + K+ + HK+ I + WSP ++ I AS Sbjct: 17 TSCQISPDGELIAICQNTDMLV--YEISSSKMMKLTTT-HKECINCLCWSPDSKCI-ASG 72 Query: 341 GTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSED 400 D + + + GHTA + +N N+ I+CS S D Sbjct: 73 SEDFTVEI---------------THIIYGRIRRLMGHTAPVISICYN-NKGNILCSSSMD 116 Query: 401 NIMQVWQMAENV 412 ++ W + Sbjct: 117 ESIKEWHVLSGT 128 Score = 48.2 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 26/202 (12%), Positives = 60/202 (29%), Gaps = 21/202 (10%) Query: 121 IEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGH 180 ++ H V ++ ++++ + + +FD + + D Sbjct: 130 LKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYD--KDWIAEDG 187 Query: 181 QKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED--VA 238 + ++ N +LL S D+ + LW+ + + Sbjct: 188 VVPISTVKFSRN-GKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLELI 246 Query: 239 WHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSA 298 + + L S D + +W+ + N + + S I + S Sbjct: 247 YPQGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEK------------HRNSPLISISASY 294 Query: 299 DKTVALWDLRNLKLKLHSFESH 320 DK L +L + + F H Sbjct: 295 DKVATL----SLNGECNLFRVH 312 >4G56-B nrPDB Length = 357 Score = 119 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 44/224 (19%), Positives = 84/224 (37%), Gaps = 21/224 (9%) Query: 123 IKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQK 182 K H+ V + + V V+D ++ + H Sbjct: 134 AKYEHDDIVKTLSVFS-DGTQAVSGGKDFSVKVWDLSQKAVLKSYN----------AHSS 182 Query: 183 EGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLL 242 E ++ P + LS +D I LWD R+ F + V WH Sbjct: 183 EVNCVAACPGKDTIFLSCGEDGRILLWDTRKPKPATRI-----DFCASDTIPTSVTWHPE 237 Query: 243 HESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTV 302 + F + + + + +N ++++ S H+ + L+++ +S LA+ S D TV Sbjct: 238 KDDTFACGDETGNVSLVNIKNPDSAQTSAV---HSQNITGLAYSYHSSPFLASISEDCTV 294 Query: 303 ALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 346 A+ D ++ SH+D + V WSP + + + G D ++ Sbjct: 295 AVLDAD--FSEVFRDLSHRDFVTGVAWSPLDHSKFTTVGWDHKV 336 Score = 99.5 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 46/276 (16%), Positives = 100/276 (36%), Gaps = 33/276 (11%) Query: 128 EGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGL 187 E V ++ + ++A+ + V +++ + S H L Sbjct: 94 EAGVTDVAWVSEKGILVASDS--GAVELWEILEKESLLVNKFAKYE------HDDIVKTL 145 Query: 188 SWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLF 247 S + +S D ++ +WD++ + H++ V VA +++F Sbjct: 146 SVFSD-GTQAVSGGKDFSVKVWDLSQKA-------VLKSYNAHSSEVNCVAACPGKDTIF 197 Query: 248 GSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL 307 S +D ++++WDTR + + T ++++P + A G V+L ++ Sbjct: 198 LSCGEDGRILLWDTRKPKPATRIDFCASDTIP-TSVTWHPEKDDTFACGDETGNVSLVNI 256 Query: 308 RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGP 367 +N + H I + +S H+ LAS D + V D Sbjct: 257 KNPDSA-QTSAVHSQNITGLAYSYHSSPFLASISEDCTVAVLD---------------AD 300 Query: 368 PELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIM 403 +F H ++ +W+P + +V D+ + Sbjct: 301 FSEVFRDLSHRDFVTGVAWSPLDHSKFTTVGWDHKV 336 Score = 75.2 bits (183), Expect = 5e-14, Method: Composition-based stats. Identities = 42/206 (20%), Positives = 68/206 (33%), Gaps = 24/206 (11%) Query: 208 LW---DINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNN 264 +W D P E G V DVAW L S + + +W+ Sbjct: 72 IWVFKDPEGAPNESLCTAGVQTEAG----VTDVAWVSEKGILVASDS--GAVELWEILEK 125 Query: 265 NTSKPSHTVD-AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE 323 + + H V LS + +G D +V +WDL + K L S+ +H E Sbjct: 126 ESLLVNKFAKYEHDDIVKTLSVFSDGTQAV-SGGKDFSVKVWDL-SQKAVLKSYNAHSSE 183 Query: 324 IFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISD 383 + V P +TI S G D R+ +WD K + + Sbjct: 184 VNCVAACPGKDTIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIP------------TS 231 Query: 384 FSWNPNEPWIICSVSEDNIMQVWQMA 409 +W+P + E + + + Sbjct: 232 VTWHPEKDDTFACGDETGNVSLVNIK 257 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 28/137 (20%), Positives = 55/137 (40%), Gaps = 20/137 (14%) Query: 277 TAEVNCLSFNPYSEFILATGSADKTVALWDL-RNLKLKLHSF--ESHKDEIFQVQWSPHN 333 A V +++ ++A+ S V LW++ L ++ F H D + + + Sbjct: 94 EAGVTDVAWVSEKGILVASDS--GAVELWEILEKESLLVNKFAKYEHDDIVKTLSVF-SD 150 Query: 334 ETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWI 393 T S G D + VWDLS+ +L + H+++++ + P + I Sbjct: 151 GTQAVSGGKDFSVKVWDLSQ--------------KAVLKSYNAHSSEVNCVAACPGKDTI 196 Query: 394 ICSVSEDNIMQVWQMAE 410 S ED + +W + Sbjct: 197 FLSCGEDGRILLWDTRK 213 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 21/148 (14%), Positives = 45/148 (30%), Gaps = 20/148 (13%) Query: 87 SVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKIN---------HEGEVNRARYM 137 + + D + EK + G G + + N H + Y Sbjct: 219 RIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAVHSQNITGLAYS 278 Query: 138 PQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYL 197 ++ +A+ + V V D + R H+ G++W+P + Sbjct: 279 YHSSPFLASISEDCTVAVLD-----------ADFSEVFRDLSHRDFVTGVAWSPLDHSKF 327 Query: 198 LSASDDHTICLWDINATPKEHRVIDAKN 225 + DH + + + + +I K Sbjct: 328 TTVGWDHKVLHHHLPSEGRTENLIATKA 355 Score = 33.6 bits (75), Expect = 0.19, Method: Composition-based stats. Identities = 15/104 (14%), Positives = 35/104 (33%), Gaps = 17/104 (16%) Query: 321 KDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAK 380 + + V W ++AS + +W++ + + F H Sbjct: 94 EAGVTDVAWVSEKGILVASDS--GAVELWEILEKESLLVNK----------FAKYEHDDI 141 Query: 381 ISDFSWNPNEPWIICSVSEDNIMQVWQMAE----NVYNDEEPEI 420 + S + + S +D ++VW +++ YN E+ Sbjct: 142 VKTLSVFSDGTQAV-SGGKDFSVKVWDLSQKAVLKSYNAHSSEV 184 >6EMK-B nrPDB Length = 303 Score = 117 bits (294), Expect = 7e-27, Method: Composition-based stats. Identities = 47/246 (19%), Positives = 94/246 (38%), Gaps = 35/246 (14%) Query: 172 QPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHT 231 P GH+ +S+ N +++++S+D TI +WD+ + H Sbjct: 66 NPVASFEGHRGNVTSVSF-QQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK--------HN 116 Query: 232 AVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTA-EVNCLSFNPYSE 290 A V +V H L S D + IWD N + +H + + LS Sbjct: 117 APVNEVVIHPNQGELI-SCDRDGNIRIWDLGEN---QCTHQLTPEDDTSLQSLSMASDGS 172 Query: 291 FILATGSADKTVALWDLRNLK-----LKLHSFESHKDEIFQVQWSPHNETILASSGTDRR 345 LA + +W++ N + F +H I ++ S + LA+ D Sbjct: 173 M-LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLS-SDVKHLATCSADHT 230 Query: 346 LHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQV 405 VW + + ++T D GH + D +++ + +++ + S D+ +++ Sbjct: 231 ARVWSIDDDFKLETTLD-------------GHQRWVWDCAFSADSAYLV-TASSDHYVRL 276 Query: 406 WQMAEN 411 W ++ Sbjct: 277 WDLSTR 282 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 47/275 (17%), Positives = 94/275 (34%), Gaps = 55/275 (20%) Query: 196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 255 L+SA DHTI W+ T R I + + D + L + Q Sbjct: 4 ILVSAGYDHTIRFWE-ALTGVCSRTIQHSDSQVNRLEITND-------KKLLATAGH-QN 54 Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 315 + ++D R N P + + H V +SF + +++ T S D T+ +WD+R+ + + Sbjct: 55 VRLYDIRTTN-PNPVASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVRSPSIPRN 112 Query: 316 SFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHG 375 H + +V P+ ++ S D + +WDL + +D + L + Sbjct: 113 --YKHNAPVNEVVIHPNQGELI-SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS 169 Query: 376 -----------------------------------GHTAKISDFSWNPNEPWIICSVSED 400 H+ I+ + + + + S D Sbjct: 170 DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHL-ATCSAD 228 Query: 401 NIMQVWQM-----AENVYNDEEPEIPASELETNTA 430 + +VW + E + + + ++A Sbjct: 229 HTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSA 263 >3BG0-A nrPDB Length = 316 Score = 116 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 59/274 (21%), Positives = 95/274 (34%), Gaps = 37/274 (13%) Query: 117 GKIEIEIKINHEGEVNRARY-MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDL 175 G+I I HEG V + + P ++A+ + V+++ E +G + Sbjct: 46 GQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR--------EENGTWEKSH 97 Query: 176 RLRGHQKEGYGLSWNPNLNGY-LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVV 234 GH + W P+ G L S D I L T + K I HT Sbjct: 98 EHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL----LTYTGEGQWEVKKINNAHTIGC 153 Query: 235 EDVAWHL----------------LHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTA 278 V+W + F S D + +W + K ++AH+ Sbjct: 154 NAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSD 213 Query: 279 EVNCLSFNPYSEF---ILATGSADKTVALW---DLRNLKLKLHSFESHKDEIFQVQWSPH 332 V +++ P +A+ S D V +W D + D ++ V WS Sbjct: 214 WVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSIT 273 Query: 333 NETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 366 ILA SG D ++ +W S G+ D G Sbjct: 274 -ANILAVSGGDNKVTLWKESVDGQWVCISDVNKG 306 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 55/250 (22%), Positives = 96/250 (38%), Gaps = 40/250 (16%) Query: 194 NGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW-HLLHESLFGSVAD 252 L + S D ++ ++D+ + GH V VAW H ++ ++ S + Sbjct: 25 GTRLATCSSDRSVKIFDVRNGGQI-----LIADLRGHEGPVWQVAWAHPMYGNILASCSY 79 Query: 253 DQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS-EFILATGSADKTVAL--WDLRN 309 D+K++IW N T + SH H + VN + + P+ ILA GS+D ++L + Sbjct: 80 DRKVIIWR-EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEG 138 Query: 310 LKLKLHSFESHKDEIFQVQWSPH---NETI-------------LASSGTDRRLHVWDLSK 353 +H V W+P I AS G D + +W Sbjct: 139 QWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW---- 194 Query: 354 IGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNE---PWIICSVSEDNIMQVWQMAE 410 ++ EDG + H+ + D +W P+ I S S+D + +W + Sbjct: 195 -------KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD 247 Query: 411 NVYNDEEPEI 420 N P++ Sbjct: 248 ASSNTWSPKL 257 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 49/215 (22%), Positives = 83/215 (38%), Gaps = 32/215 (14%) Query: 228 TGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSF-N 286 T H ++ D L + + D+ + I+D RN + H V +++ + Sbjct: 10 TSHEDMIHDAQMDYYGTRL-ATCSSDRSVKIFDVRNGG-QILIADLRGHEGPVWQVAWAH 67 Query: 287 PYSEFILATGSADKTVALWDLRNL-KLKLHSFESHKDEIFQVQWSPHN-ETILASSGTDR 344 P ILA+ S D+ V +W N K H H + V W+PH+ ILA +D Sbjct: 68 PMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDG 127 Query: 345 RLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNP-------------NEP 391 + + +G E+ I+ HT + SW P +P Sbjct: 128 AISL-----------LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKP 176 Query: 392 WII---CSVSEDNIMQVWQMAENVYNDEEPEIPAS 423 I S DN++++W+ E+ EE ++ A Sbjct: 177 NYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAH 211 >6F1U-h nrPDB Length = 612 Score = 114 bits (286), Expect = 7e-26, Method: Composition-based stats. Identities = 49/257 (19%), Positives = 101/257 (39%), Gaps = 13/257 (5%) Query: 130 EVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW 189 V A + + ++ T S ++++D + P + L H Y ++ Sbjct: 308 AVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTP----VQRTPLSAAAHTHPVYCVNV 363 Query: 190 NPNLNGY-LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFG 248 N + L+S S D IC W ++ ++ + V +++ + + F Sbjct: 364 VGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHK-QSKAVAVTSMSFPVGDVNNFV 422 Query: 249 SVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP-----YSEFILATGSADKTVA 303 +++ + R+ + + S + H + + + + T S D TV Sbjct: 423 VGSEEGSVYT-ACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVK 481 Query: 304 LWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDA 363 LW +N K L+SFE + ++ V WSP + + A RL +W+L+ E + + Sbjct: 482 LWSTKNNK-PLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASIS 540 Query: 364 EDGPPELLFIHGGHTAK 380 +G P L + H+ + Sbjct: 541 VEGNPALNRVRWTHSGR 557 Score = 86.4 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 46/286 (16%), Positives = 82/286 (28%), Gaps = 38/286 (13%) Query: 140 NACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLS 199 N A P LV++ + PE CQ ++ ++ Sbjct: 274 NNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQS---------AVMSATFAKFHPNLVVG 324 Query: 200 ASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDV-AWHLLHESLFGSVADDQKLMI 258 + I LWD + + + HT V V + S++ D K+ Sbjct: 325 GTYSGQIVLWDNRSNKRTPVQRTPLSA-AAHTHPVYCVNVVGTQNAHNLISISTDGKICS 383 Query: 259 WDTRNNNTSKPSHTVDAHTA----EVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK- 313 W + + S + H V +SF GS + +V R+ Sbjct: 384 WSLDMLSHPQDSMELV-HKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYT-ACRHGSKAG 441 Query: 314 -LHSFESHKDEIFQVQWSP-----HNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGP 367 FE H+ I + + +S D + +W S ED Sbjct: 442 ISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNNKPLYSFED----- 496 Query: 368 PELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVY 413 + + D W+P P + V + +W + + Sbjct: 497 ---------NAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTE 533 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 29/137 (21%), Positives = 55/137 (40%), Gaps = 15/137 (10%) Query: 177 LRGHQKEGYGLSWNP-----NLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHT 231 GHQ G+ + + + +++S D T+ LW F + Sbjct: 446 FEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNN-------KPLYSFEDNA 498 Query: 232 AVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAE-VNCLSFNPYSE 290 V DV W H +LF V +L +W+ NN+T P+ ++ +N + + Sbjct: 499 GYVYDVMWSPTHPALFACVDGMGRLDLWNL-NNDTEVPTASISVEGNPALNRVRWTHSGR 557 Query: 291 FILATGSADKTVALWDL 307 I A G ++ + ++D+ Sbjct: 558 EI-AVGDSEGQIVIYDV 573 >6GMH-W nrPDB Length = 305 Score = 114 bits (285), Expect = 7e-26, Method: Composition-based stats. Identities = 55/321 (17%), Positives = 107/321 (33%), Gaps = 69/321 (21%) Query: 126 NHEGEVNRARYMP---QNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQK 182 H+ + + +N+ + T + V V+ + L GHQ Sbjct: 14 AHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDE--------RLDLQWSLEGHQL 65 Query: 183 EGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVI--------------------- 221 + + + S+S D I LWD+ + + Sbjct: 66 GVVSVDIS-HTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATG 124 Query: 222 --------------DAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTS 267 + + +A+ + L S A D + I+D T Sbjct: 125 THVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYL-ASGAIDGIINIFDI---ATG 180 Query: 268 KPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQV 327 K HT++ H + L+F+P S+ +L T S D + ++D+++ L + H + V Sbjct: 181 KLLHTLEGHAMPIRSLTFSPDSQ-LLVTASDDGYIKIYDVQHANLAG-TLSGHASWVLNV 238 Query: 328 QWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWN 387 + P + T SS +D+ + VWD+ + D +D + + G Sbjct: 239 AFCPDD-THFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSK--------- 288 Query: 388 PNEPWIICSVSEDNIMQVWQM 408 I SV +D + ++ Sbjct: 289 ------IVSVGDDQEIHIYDC 303 Score = 71.4 bits (173), Expect = 7e-13, Method: Composition-based stats. Identities = 36/181 (19%), Positives = 65/181 (35%), Gaps = 34/181 (18%) Query: 263 NNNTSKPSHTVDAHTAEVNCLSF---NPYSEFILATGSADKTVALWDLRNLKLKLH-SFE 318 N AH + +++ + + TGS D V +W R+ +L L S E Sbjct: 2 TNQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLE 61 Query: 319 SHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIH---- 374 H+ + V S I ASS D + +WDL + +S + L F Sbjct: 62 GHQLGVVSVDISHTLP-IAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQY 120 Query: 375 ---GGHTAKIS---------------------DFSWNPNEPWIICSVSEDNIMQVWQMAE 410 G H K++ +++P+ ++ S + D I+ ++ +A Sbjct: 121 LATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYL-ASGAIDGIINIFDIAT 179 Query: 411 N 411 Sbjct: 180 G 180 >4J0W-A nrPDB Length = 343 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 49/239 (20%), Positives = 95/239 (39%), Gaps = 29/239 (12%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFT----GHTA 232 LRGHQ L P+ + SA+ D +I W + + K H + AK GH++ Sbjct: 10 LRGHQLSITCLVVTPDDSAIF-SAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSS 68 Query: 233 VVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI 292 V +A + L S + ++IW + + +T H V+ L+F + + Sbjct: 69 HVLCMAISSDGKYL-ASGDRSKLILIW---EAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 124 Query: 293 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLS 352 +T S D++V +W++ + + H+D + + + E + + G D + VW Sbjct: 125 YST-SHDRSVKVWNVAENSY-VETLFGHQDAVAALD-ALSRECCVTAGGRDGTVRVW--- 178 Query: 353 KIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 P E + GH I + + S ++D + +W +++ Sbjct: 179 ------------KIPEESQLVFYGHQGSID--CIHLINEEHMVSGADDGSVALWGLSKK 223 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 48/296 (16%), Positives = 104/296 (35%), Gaps = 49/296 (16%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H V + + +A+ S +L+++ + CQ GH+ Sbjct: 65 GHSSHVLCMA-ISSDGKYLASGDRSKLILIWE----------AQSCQHLYTFTGHRDAVS 113 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 GL++ + L S S D ++ +W++ GH V + L E Sbjct: 114 GLAFRRGTHQ-LYSTSHDRSVKVWNVAEN-------SYVETLFGHQDAVAALD-ALSREC 164 Query: 246 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 305 + D + +W + H ++C+ + +E + +G+ D +VALW Sbjct: 165 CVTAGGRDGTVRVWKIPEES----QLVFYGHQGSIDCI--HLINEEHMVSGADDGSVALW 218 Query: 306 DLRNLKLKLHSFESHK----------DEIFQVQWSPHNETILASSGTDRRLHVWDLSKIG 355 L + E+H I V + N ++A+ + +W + G Sbjct: 219 GLSKKRPLALQREAHGLRGEPGLEQPFWISSVA-ALLNTDLVATGSHSSCVRLW---QCG 274 Query: 356 EEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIM-QVWQMAE 410 E D P + I+ ++ + +++ V +++ + + W++ E Sbjct: 275 EGFRQLDLLCDIPLV--------GFINSLKFSSSGDFLVAGVGQEHRLGRWWRIKE 322 Score = 87.9 bits (216), Expect = 8e-18, Method: Composition-based stats. Identities = 31/195 (15%), Positives = 74/195 (37%), Gaps = 27/195 (13%) Query: 224 KNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVD--------A 275 + GH + + ++F S A D ++ W + Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIF-SAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPG 65 Query: 276 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET 335 H++ V C++ + ++ LA+G K + +W+ ++ L++F H+D + + + Sbjct: 66 HSSHVLCMAISSDGKY-LASGDRSKLILIWEAQS-CQHLYTFTGHRDAVSGLAFR-RGTH 122 Query: 336 ILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIIC 395 L S+ DR + VW++++ ++ +D L + + Sbjct: 123 QLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALS---------------RECCVT 167 Query: 396 SVSEDNIMQVWQMAE 410 + D ++VW++ E Sbjct: 168 AGGRDGTVRVWKIPE 182 Score = 67.1 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 29/155 (18%), Positives = 54/155 (34%), Gaps = 29/155 (18%) Query: 270 SHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF-----------E 318 + H + CL P I + + D ++ W + + + KLH Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIF-SAAKDCSIIKWSVESGR-KLHVIPRAKKGAEGKPP 64 Query: 319 SHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHT 378 H + + S + LAS + + +W+ + L+ GH Sbjct: 65 GHSSHVLCMAIS-SDGKYLASGDRSKLILIWEAQSC--------------QHLYTFTGHR 109 Query: 379 AKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVY 413 +S ++ + S S D ++VW +AEN Y Sbjct: 110 DAVSGLAFRR-GTHQLYSTSHDRSVKVWNVAENSY 143 >5OQL-L nrPDB Length = 557 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 45/210 (21%), Positives = 83/210 (39%), Gaps = 19/210 (9%) Query: 149 PSSDVLVFDYTKHPSKPEPSGECQPDLRLRG---HQKEGYGLSWNPNLNGYLLSASDDHT 205 P VLV + G+ + L+ H++ + W+P L+S SDD T Sbjct: 109 PDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKT 168 Query: 206 ICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHL--LHESLFGSVADDQKLMIWDTRN 263 + LWD+ + D +FTGHT V A+ + +L S + D+ + +WD R Sbjct: 169 VRLWDLPSN-------DPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARA 221 Query: 264 NNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE 323 + T H + + P +LA +++ DL K L +H+ Sbjct: 222 PGGA--VMTFK-HADPIEDVLPLPSGTTLLAASG--NAISVLDLVAAK-PLRLITNHQKT 275 Query: 324 IFQVQWSPHNETILASSGTDRRLHVWDLSK 353 + + + ++ S D + V++ + Sbjct: 276 VTSLSLASQGRRVV-SGSLDGHVKVFETTS 304 Score = 94.9 bits (234), Expect = 6e-20, Method: Composition-based stats. Identities = 39/204 (19%), Positives = 64/204 (31%), Gaps = 36/204 (17%) Query: 242 LHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKT 301 + + D ++ ++D + T H V ++P L + S DKT Sbjct: 109 PDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKT 168 Query: 302 VALWDLRNLKLKLHSFESHKDEIFQVQWSP--HNETILASSGTDRRLHVWDLSKIGEEQS 359 V LWDL + F H D + + P N +L S D + VWD G Sbjct: 169 VRLWDLPS-NDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVM 227 Query: 360 TEDAEDGPPELLFIHGG---------------------------HTAKISDFSWNPNEPW 392 T D ++L + G H ++ S Sbjct: 228 TFKHADPIEDVLPLPSGTTLLAASGNAISVLDLVAAKPLRLITNHQKTVTSLSLASQGRR 287 Query: 393 IICSVSEDNIMQV-----WQMAEN 411 ++ S S D ++V W + Sbjct: 288 VV-SGSLDGHVKVFETTSWNVVAG 310 Score = 87.5 bits (215), Expect = 9e-18, Method: Composition-based stats. Identities = 33/185 (17%), Positives = 62/185 (33%), Gaps = 25/185 (13%) Query: 127 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 186 H+ V ++ P + + + V ++D + P GH Sbjct: 143 HKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSND----------PTRLFTGHTDYVRC 192 Query: 187 LSWNPNL--NGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHE 244 ++ P + L+S S D T+ +WD A H +EDV Sbjct: 193 GAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFK-------HADPIEDVLPLPSGT 245 Query: 245 SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 304 +L + + + D +KP + H V LS ++ +GS D V + Sbjct: 246 TLLAASG--NAISVLDL---VAAKPLRLITNHQKTVTSLSLASQGRRVV-SGSLDGHVKV 299 Query: 305 WDLRN 309 ++ + Sbjct: 300 FETTS 304 Score = 76.7 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 39/210 (18%), Positives = 70/210 (33%), Gaps = 25/210 (11%) Query: 207 CLWDINATPKEHRVIDAKNIFT-------GHTAVVEDVAWHLLHESLFGSVADDQKLMIW 259 W K H I G TA+V + +V ++ I+ Sbjct: 25 RYWRSFKKQKSHTSTANWPISHISFPASLGTTALVSSSLVAAAKTNDLFAVTAGPRVEIF 84 Query: 260 DTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL--HSF 317 R +P T+ +E +C P +L G + ++D+ + ++ Sbjct: 85 SIRK---REPLKTIGRFDSEAHCGEIRPDGR-VLVAGEDTGRMQVFDVGQGTRAVILKTW 140 Query: 318 ESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGH 377 HK ++ +WSP T L S D+ + +WDL + D F+ G Sbjct: 141 HIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSA 200 Query: 378 TAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 + ++ S S D ++VW Sbjct: 201 NSN------------LLVSGSYDETVRVWD 218 Score = 45.2 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 25/144 (17%), Positives = 50/144 (34%), Gaps = 25/144 (17%) Query: 275 AHTAEVNC--LSFNPYSEFILATGSADKTVALWDLRNLKLKLHS----FESHKDEIFQVQ 328 TA V+ ++ ++ T V ++ +R + E+H EI Sbjct: 54 GTTALVSSSLVAAAKTNDLFAVTAG--PRVEIFSIRKREPLKTIGRFDSEAHCGEIR--- 108 Query: 329 WSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNP 388 P ++A T R+ V+D+ + + H + W+P Sbjct: 109 --PDGRVLVAGEDT-GRMQVFDVGQGTRAVILKTWHI-----------HKQPVWVTKWSP 154 Query: 389 NEPWIICSVSEDNIMQVWQMAENV 412 E + S S+D +++W + N Sbjct: 155 TELTTLMSCSDDKTVRLWDLPSND 178 >3ODT-A nrPDB Length = 313 Score = 112 bits (279), Expect = 4e-25, Method: Composition-based stats. Identities = 49/247 (19%), Positives = 89/247 (36%), Gaps = 39/247 (15%) Query: 173 PDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTA 232 P L GHQ LS+ +G ++S S D T +W + H A Sbjct: 96 PLYTLIGHQGNVCSLSF---QDGVVISGSWDKTAKVWKEGS---------LVYNLQAHNA 143 Query: 233 VVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDA-HTAEVNCLSFNPYSEF 291 V D E+ F + + D+ + +W K T H V L+ F Sbjct: 144 SVWDAKVVSFSENKFLTASADKTIKLW-----QNDKVIKTFSGIHNDVVRHLAVVDDGHF 198 Query: 292 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 I + S D + L D+ + L ++E H+ ++ ++ P+ + + S G DR + +W Sbjct: 199 I--SCSNDGLIKLVDMHTGDV-LRTYEGHESFVYCIKLLPNGD--IVSCGEDRTVRIWSK 253 Query: 352 SKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 +Q I N I+ S DN+++++ ++ Sbjct: 254 ENGSLKQVITLPA--------------ISIWSVDCMSNGDIIV--GSSDNLVRIFSQEKS 297 Query: 412 VYNDEEP 418 + E+ Sbjct: 298 RWASEDE 304 Score = 95.6 bits (236), Expect = 4e-20, Method: Composition-based stats. Identities = 49/235 (20%), Positives = 81/235 (34%), Gaps = 35/235 (14%) Query: 123 IKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQK 182 I H+G V + Q+ VI + + V+ E L+ H Sbjct: 99 TLIGHQGNVCSLSF--QDGVVI-SGSWDKTAKVWK------------EGSLVYNLQAHNA 143 Query: 183 EGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTG-HTAVVEDVAWHL 241 + L+AS D TI LW + F+G H VV +A Sbjct: 144 SVWDAKVVSFSENKFLTASADKTIKLW---------QNDKVIKTFSGIHNDVVRHLAVVD 194 Query: 242 LHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKT 301 F S ++D + + D +T T + H + V C+ P + + + D+T Sbjct: 195 DGH--FISCSNDGLIKLVDM---HTGDVLRTYEGHESFVYCIKLLPNGD--IVSCGEDRT 247 Query: 302 VALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGE 356 V +W N LK I+ V + + I+ SS D + ++ K Sbjct: 248 VRIWSKENGSLK-QVITLPAISIWSVDCMSNGDIIVGSS--DNLVRIFSQEKSRW 299 Score = 92.5 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 47/268 (17%), Positives = 93/268 (34%), Gaps = 44/268 (16%) Query: 166 EPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKN 225 +P Q L+GH ++ + + + S S D T+ LW + V + Sbjct: 3 DPFTGYQLSATLKGHDQDVRDV--VAVDDSKVASVSRDGTVRLWSKDDQWLGTVVYTGQG 60 Query: 226 IFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSF 285 V + + L D + + P +T+ H V LSF Sbjct: 61 FL-------NSVCYDS-EKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSF 112 Query: 286 NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRR 345 + ++ +GS DKT +W +++ ++H ++ + +E ++ D+ Sbjct: 113 ---QDGVVISGSWDKTAKVW---KEGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKT 166 Query: 346 LHVWDLSKIGEEQS------------------TEDAEDGPPELLFIH--------GGHTA 379 + +W K+ + S + DG +L+ +H GH + Sbjct: 167 IKLWQNDKVIKTFSGIHNDVVRHLAVVDDGHFISCSNDGLIKLVDMHTGDVLRTYEGHES 226 Query: 380 KISDFSWNPNEPWIICSVSEDNIMQVWQ 407 + PN I S ED +++W Sbjct: 227 FVYCIKLLPNGD--IVSCGEDRTVRIWS 252 >5CXC-A nrPDB Length = 510 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 59/332 (17%), Positives = 115/332 (34%), Gaps = 51/332 (15%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H + A+++ + +A+ V V+ YT+ +GE +P L L GH Sbjct: 190 GHTASIKAAKFLTSDR--LASAGMDRTVRVWKYTESDHF---TGELKPTLELYGHTGSVD 244 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVID----------------------- 222 L + + + ++L+AS D I W + Sbjct: 245 WLDVDGH-SKHILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRG 303 Query: 223 AKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNC 282 +++ HTA + ++ S + D + D T+ ++ Sbjct: 304 PLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTL-TLTHPLLSLSA 362 Query: 283 LSFNPYSEFILATGSADKTVALWDLR--NLKLKLHSFESHKDEIFQVQWSPHNETILASS 340 L+ + +LA G++ + + + D R + + + H +++ + SP NE L S Sbjct: 363 LTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSG 422 Query: 341 GTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHG---------------GHTAKISDFS 385 D VWDL + E + G E +++ G K+ Sbjct: 423 SHDGTCRVWDLRSVRPATKEEGSLGGVSEPVYVIERESWASKGKKKRPVAGDGCKVFSVV 482 Query: 386 WNPNEPWIICSVSEDNIMQVWQMAENVYNDEE 417 W+ I S ED +QV N+ +++ Sbjct: 483 WDKLG---IFSGGEDKKVQV-NRGRNIVTEQK 510 Score = 97.9 bits (242), Expect = 8e-21, Method: Composition-based stats. Identities = 45/282 (15%), Positives = 83/282 (29%), Gaps = 73/282 (25%) Query: 196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 255 +LSAS D + +W+ + + GHTA ++ + S D+ Sbjct: 160 RVLSASYDGLLRIWNASGSV---IATSPSGSHGGHTASIKAAKFLTSDR--LASAGMDRT 214 Query: 256 LMIWDTRNNNT----SKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL---- 307 + +W ++ KP+ + HT V+ L + +S+ IL T SAD + W Sbjct: 215 VRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHIL-TASADGAIGFWSASKAS 273 Query: 308 -----------------RNLKLKLHSFES--------HKDEIFQVQWSPHNETILASSGT 342 R + + + H + P + T+ S+ Sbjct: 274 APEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQ 333 Query: 343 DRRLHVWDLSKIGEEQSTEDAE----------------------------------DGPP 368 D + DL+ + Sbjct: 334 DHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSAT 393 Query: 369 ELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 410 + GH K+ S +P + + S S D +VW + Sbjct: 394 TSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRS 435 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 26/157 (16%), Positives = 52/157 (33%), Gaps = 32/157 (20%) Query: 276 HTAEVNCLSF----NPYSEFI---------------LATGSADKTVALWDLRNLKLKLH- 315 H V+ + +P + + + S D + +W+ + Sbjct: 125 HDDWVSAVDVLSATSPAGRWSSAANSSAAVQPGQERVLSASYDGLLRIWNASGSVIATSP 184 Query: 316 --SFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFI 373 S H I ++ + LAS+G DR + VW ++ D G + Sbjct: 185 SGSHGGHTASIKAAKFLTSDR--LASAGMDRTVRVWKYTES-------DHFTGELKPTLE 235 Query: 374 HGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 410 GHT + + + I+ + S D + W ++ Sbjct: 236 LYGHTGSVDWLDVDGHSKHIL-TASADGAIGFWSASK 271 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 34/194 (17%), Positives = 65/194 (33%), Gaps = 26/194 (13%) Query: 241 LLHESLFGSVADDQKLMIWDTRNNN-TSKPSHTVDAHTAEVNCLSFNPYSEFILATGSAD 299 + S + D L IW+ + + PS + HTA + F + LA+ D Sbjct: 155 QPGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKF--LTSDRLASAGMD 212 Query: 300 KTVALWDLRNLK------LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSK 353 +TV +W H + + H++ IL ++ D + W SK Sbjct: 213 RTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHIL-TASADGAIGFWSASK 271 Query: 354 IGE----------------EQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSV 397 ++T L + HTA + ++P + + S Sbjct: 272 ASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSA 331 Query: 398 SEDNIMQVWQMAEN 411 S+D+ ++ + Sbjct: 332 SQDHTVRTLDLTTG 345 Score = 45.9 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 25/126 (19%), Positives = 43/126 (34%), Gaps = 32/126 (25%) Query: 307 LRNLKLKLHSFE-SHKDEIFQVQW----SPHNETI---------------LASSGTDRRL 346 +R+L ++ H D + V SP + S+ D L Sbjct: 111 VRSLIPPVYEASFEHDDWVSAVDVLSATSPAGRWSSAANSSAAVQPGQERVLSASYDGLL 170 Query: 347 HVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 +W+ S S + HGGHTA I + ++ + S D ++VW Sbjct: 171 RIWNASGSVIATSPSGS----------HGGHTASIKAAKFLTSDR--LASAGMDRTVRVW 218 Query: 407 QMAENV 412 + E+ Sbjct: 219 KYTESD 224 >6ELZ-p nrPDB Length = 460 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 50/318 (15%), Positives = 97/318 (30%), Gaps = 101/318 (31%) Query: 181 QKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH 240 + L + + +++S S D + WD++ + ++GH+ + V + Sbjct: 103 EDWVSSLDVG-DGSKHIISGSYDGIVRTWDLSGN--------VQKQYSGHSGPIRAVKY- 152 Query: 241 LLHESLFGSVADDQKLMIWDTRNNNT--------------------SKPSHTVDAHTAEV 280 + + S +D+ L +W T+N++ K ++ H A V Sbjct: 153 -ISNTRLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPV 211 Query: 281 NCLSFNPYSEFILATGSADKTVALW--------------DLRNLKLKLHS---------- 316 + + S + + S D ++ W D+ N K+ + Sbjct: 212 VSIDVSDNSR--ILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTM 269 Query: 317 -------------FESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL------------ 351 ESH + QV + + T+ S D + WDL Sbjct: 270 KDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTS 329 Query: 352 -----------------SKIGEEQSTEDAEDGPPELLFIHG--GHTAKISDFSWNPNEPW 392 + D G + GH +S P + Sbjct: 330 YSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEY 389 Query: 393 IICSVSEDNIMQVWQMAE 410 I+CS S D ++VW + Sbjct: 390 ILCSGSHDGTVKVWDVRS 407 Score = 106 bits (265), Expect = 2e-23, Method: Composition-based stats. Identities = 61/328 (18%), Positives = 104/328 (31%), Gaps = 66/328 (20%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSG-------------ECQ 172 H G + +Y+ V + + ++ K + + Sbjct: 142 GHSGPIRAVKYISNTRLV--SAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGK 199 Query: 173 PDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWD---------------------- 210 L GH+ + + N +LSAS D++I W Sbjct: 200 TLAILEGHKAPVVSIDVS--DNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKI 257 Query: 211 ---------INATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDT 261 + R ++ HTA VE V + ++ SV+ D + WD Sbjct: 258 STAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDL 317 Query: 262 RNNNTSKPSHTVDAHTAEVNCLSFNPYSE-FILATGSADKTVALWDLR---NLKLKLHSF 317 +D T + LS S +LA GS+ + + L D R + K+ Sbjct: 318 VTARC------IDTRTTSYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQL 371 Query: 318 ESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGH 377 HK+ + + P NE IL S D + VWD+ + + + G Sbjct: 372 IGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQK------GV 425 Query: 378 TAKISDFSWNPNEPWIICSVSEDNIMQV 405 K+ W E I S +D +Q+ Sbjct: 426 NDKVFAVKWA--EKVGIISAGQDKKIQI 451 Score = 59.4 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 29/182 (15%), Positives = 55/182 (30%), Gaps = 38/182 (20%) Query: 113 GSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGE-- 170 G++ + + + +H V + + + V + + + +D + Sbjct: 272 GTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYS 331 Query: 171 --------------CQPDLR-------------------LRGHQKEGYGLSWNPNLNGYL 197 C R L GH+ L P L Sbjct: 332 LLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYIL 391 Query: 198 LSASDDHTICLWDINATPKEHRVI-DAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 256 S S D T+ +WD+ +T + + + K++ G V V W S D+K+ Sbjct: 392 CSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVKWAEKVG--IISAGQDKKI 449 Query: 257 MI 258 I Sbjct: 450 QI 451 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 16/96 (16%), Positives = 33/96 (34%), Gaps = 18/96 (18%) Query: 319 SHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHT 378 S++D + + + S D + WDLS ++Q + GH+ Sbjct: 101 SNEDWVSSLDVG-DGSKHIISGSYDGIVRTWDLSGNVQKQ---------------YSGHS 144 Query: 379 AKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYN 414 I + N + S D +++W+ + Sbjct: 145 GPIRAVKYISN--TRLVSAGNDRTLRLWKTKNDDLK 178 Score = 29.8 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 15/65 (23%), Positives = 25/65 (38%), Gaps = 4/65 (6%) Query: 368 PELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENV---YNDEEPEIPASE 424 P + +S + I S S D I++ W ++ NV Y+ I A + Sbjct: 93 PPSYLNSFSNEDWVSSLDV-GDGSKHIISGSYDGIVRTWDLSGNVQKQYSGHSGPIRAVK 151 Query: 425 LETNT 429 +NT Sbjct: 152 YISNT 156 >5WLC-LJ nrPDB Length = 513 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 58/291 (19%), Positives = 103/291 (35%), Gaps = 37/291 (12%) Query: 123 IKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQK 182 + V + PQ+ A + S+ V +F Q + Sbjct: 34 QLVKEHNSVTHISFNPQHPHDFAVTS-STRVQIFSSR----------TRQVIKTFSRFKD 82 Query: 183 EGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLL 242 Y S+ + L + + ++D R I + H V +H Sbjct: 83 VVYSASFRSD-GKLLCAGDATGLVSVYDSY----NPRTILLSINASTHPTHVT--KFHTQ 135 Query: 243 HESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTV 302 + + +DD+ +WD +N +P + T V LSF P + ++ATGS D + Sbjct: 136 DNKILATASDDRVTRLWDI--SNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLI 193 Query: 303 ALWDLRN-LKLKLHSFESHKDEIFQV-QWSPHNETILASSGTDRRLHVWDLSKIGEEQST 360 L+D R+ ++S H + V SP T + S G VWDL+ + Sbjct: 194 RLYDTRSSGSTPIYSLN-HDQPVENVIAVSP---TQIVSCGG-NNFKVWDLTSNKKLYER 248 Query: 361 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 + L + +F +P + +I S S D ++V+ +N Sbjct: 249 GNFNKAVTCL--------DYVENFD-SPMQSALIAS-SLDGHVKVFDPLDN 289 Score = 93.3 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 48/262 (18%), Positives = 90/262 (34%), Gaps = 37/262 (14%) Query: 158 YTKHPSKPEPSGECQPDLR-------LRGHQKEGYGLSWNP-NLNGYLLSASDDHTICLW 209 +K P P+ + Q R ++ H +S+NP + + + +++S + ++ Sbjct: 10 TSKAPLLPQQTTPEQRYWRQYTSAQLVKEH-NSVTHISFNPQHPHDFAVTSST--RVQIF 66 Query: 210 DINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKP 269 R F+ VV ++ + L + ++D+ N T Sbjct: 67 S-------SRTRQVIKTFSRFKDVVYSASFRSDGKLLCA-GDATGLVSVYDSYNPRTILL 118 Query: 270 SHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQW 329 S H V F+ ILAT S D+ LWD+ N D + + + Sbjct: 119 SINASTHPTHVT--KFHTQDNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSF 176 Query: 330 SPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPN 389 P ++A+ D + ++D G D P E + + +P Sbjct: 177 IPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVE------------NVIAVSPT 224 Query: 390 EPWIICSVSEDNIMQVWQMAEN 411 + I S N +VW + N Sbjct: 225 Q---IVSCG-GNNFKVWDLTSN 242 Score = 80.6 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 46/265 (17%), Positives = 87/265 (32%), Gaps = 46/265 (17%) Query: 127 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 186 H V ++ Q+ ++AT + ++D + +P L L G Sbjct: 125 HPTHVT--KFHTQDNKILATASDDRVTRLWDISNAY---------EPQLELTGATDYVRT 173 Query: 187 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 246 LS+ P + + S D I L+D ++ H VE+V + + Sbjct: 174 LSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIY------SLNHDQPVENVI--AVSPTQ 225 Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSF-----NPYSEFILATGSADKT 301 S + +WD +N K + V CL + +P ++A+ S D Sbjct: 226 IVSCGGNNF-KVWDLTSN---KKLYERGNFNKAVTCLDYVENFDSPMQSALIAS-SLDGH 280 Query: 302 VALWDLRNLKLKLHSFE-----SHKDEIFQVQWSP---HNETILASSGTDRRLHVWDLSK 353 V ++D L +F+ + SP L + + L + Sbjct: 281 VKVFD------PLDNFQVKFGWKFSGPVLSCAVSPSTAQGNRHLVAGLSSGLLAI---RT 331 Query: 354 IGEEQSTEDAEDGPPELLFIHGGHT 378 +E+ + D E+ P + Sbjct: 332 KKKEKRSSDKENAPASFNKNAKSNN 356 >5A9Q-7 nrPDB Length = 360 Score = 105 bits (261), Expect = 5e-23, Method: Composition-based stats. Identities = 52/291 (17%), Positives = 110/291 (37%), Gaps = 38/291 (13%) Query: 144 IATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW-NPNLNGYLLSASD 202 +AT + V V+D ++ SG+ + H + ++W +P L S S Sbjct: 27 MATCSSDQSVKVWDKSE-------SGDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSF 79 Query: 203 DHTICLWDINATPKEHRV-----IDAKNIFTGHTAVVEDVAWHLLHESL-FGSVADDQKL 256 D T +W+ ++ + V DV + H L + + D + Sbjct: 80 DRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIV 139 Query: 257 MIW---DTRNNNTSKPSHTVDAHTAEVNCLSFNPYS----EFILATGSADK------TVA 303 I+ D N + H + +C+S+NP S ++A GS D V Sbjct: 140 RIYEAPDVMNLSQWSLQHEISC-KLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQ 198 Query: 304 LWDLRNLK---LKLHSFESHKDEIFQVQWSPHNET---ILASSGTDRRLHVWDLSKIGEE 357 +++ K + + D + + ++P+ ILA + D + ++ L + +E Sbjct: 199 IFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD--VRIFTLKPVRKE 256 Query: 358 QSTEDA-EDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 ++ ++ H +++ SWN ++ S +D +++W+ Sbjct: 257 LTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGT-VLASSGDDGCVRLWK 306 Score = 83.3 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 48/255 (18%), Positives = 98/255 (38%), Gaps = 37/255 (14%) Query: 127 HEGEVNRARY-MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGE--CQPDLRLRGHQKE 183 H G V R + P+ V+A+ + V++ S + G+ L + Sbjct: 56 HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTS 115 Query: 184 GYGLSWNP-NLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLL 242 + + P ++ L + S D + +++ + I ++W+ Sbjct: 116 VTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISC--KLSCSCISWNPS 173 Query: 243 ----HESLFGSVADDQK------LMIWDT-RNNNTSKPSHTVDAHTAEVNCLSFNPY--- 288 H + +DD + I++ N + T+ T V+ ++F P Sbjct: 174 SSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGR 233 Query: 289 SEFILATGSADKTVALWDLRNLKLKLHS--------------FESHKDEIFQVQWSPHNE 334 S ILA + D V ++ L+ ++ +L S F++H ++++V W+ Sbjct: 234 SFHILAIATKD--VRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITG- 290 Query: 335 TILASSGTDRRLHVW 349 T+LASSG D + +W Sbjct: 291 TVLASSGDDGCVRLW 305 Score = 82.1 bits (201), Expect = 4e-16, Method: Composition-based stats. Identities = 36/214 (16%), Positives = 86/214 (40%), Gaps = 33/214 (15%) Query: 230 HTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSF-NPY 288 H ++ DV++ + + + DQ + +WD + + + H+ V +++ +P Sbjct: 11 HKDLIHDVSFDFHGRRM-ATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPE 69 Query: 289 SEFILATGSADKTVALWD-----------LRNLKLKLHSFESHKDEIFQVQWSPHN-ETI 336 +LA+ S D+T A+W+ ++ +K + + + V+++P + + Sbjct: 70 FGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLM 129 Query: 337 LASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW---- 392 LA+ D + +++ + + +L S SWNP+ Sbjct: 130 LATCSADGIVRIYEAPDVMNLSQWSLQHEISCKL---------SCSCISWNPSSSRAHSP 180 Query: 393 IICSVSEDN------IMQVWQMAENVYNDEEPEI 420 +I S+D+ +Q+++ EN + E Sbjct: 181 MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAET 214 Score = 59.4 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 32/223 (14%), Positives = 76/223 (34%), Gaps = 39/223 (17%) Query: 131 VNRARYMPQN-ACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW 189 V ++ P++ ++AT + V +++ + + S + + +L +SW Sbjct: 116 VTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLS-----CSCISW 170 Query: 190 NPNLNG----YLLSASDDH------TICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW 239 NP+ + + SDD + +++ N +++ + T V D+A+ Sbjct: 171 NPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTV---TDPVHDIAF 227 Query: 240 HLLHE---SLFGSVADDQKLMIWDTR------------NNNTSKPSHTVDAHTAEVNCLS 284 + D + I+ + D H ++V +S Sbjct: 228 APNLGRSFHILAIATKD--VRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVS 285 Query: 285 FNPYSEFILATGSADKTVALWDLR--NLKLKLHSFESHKDEIF 325 +N + +LA+ D V LW + + + + Sbjct: 286 WN-ITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVN 327 Score = 45.5 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 35/208 (16%), Positives = 70/208 (33%), Gaps = 26/208 (12%) Query: 105 EKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSD------VLVFDY 158 E + + EI K++ ++ +IA + S V +F+Y Sbjct: 143 EAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEY 202 Query: 159 TKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLN---GYLLSASDDHTICLWDINATP 215 ++ K + + +++ PNL L A+ D + ++ + Sbjct: 203 NENTRKYAKAETLMTV------TDPVHDIAFAPNLGRSFHILAIATKD--VRIFTLKPVR 254 Query: 216 KEHRV--------IDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTS 267 KE I F H + V V+W++ + S DD + +W + Sbjct: 255 KELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGT-VLASSGDDGCVRLWKANYMDNW 313 Query: 268 KPSHTVDAHTAEVNCLSFNPYSEFILAT 295 K + + + + VN S S L + Sbjct: 314 KCTGILKGNGSPVNGSSQQGTSNPSLGS 341 >5WYK-BB nrPDB Length = 943 Score = 102 bits (253), Expect = 4e-22, Method: Composition-based stats. Identities = 51/341 (14%), Positives = 115/341 (33%), Gaps = 85/341 (24%) Query: 148 TPSSDVLVFDYTKHPSKPEPSGECQ-PDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTI 206 T S+ + + P + + L+G + + + + + N L +AS+ ++ Sbjct: 357 TSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRTDVRSIDIS-DDNKLLATASN-GSL 414 Query: 207 CLWDINATPKEHRVIDAKNIFTG-----------------------------------HT 231 +W+I T K R + T H Sbjct: 415 KIWNIK-THKCIRTFECGYALTCKFLPGGLLVILGTRNGELQLFDLASSSLLDTIEDAHD 473 Query: 232 AVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKP------SHTVDAH-------TA 278 A + + + L + + D+ + WD + N+ P + H T Sbjct: 474 AAIWSLDLTSDGKRLV-TGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTD 532 Query: 279 EVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 338 ++ C+ +P + LA D TV ++ L ++K L HK + + S + ++ Sbjct: 533 DILCVRVSPDDRY-LAISLLDNTVKVFFLDSMKFYLS-LYGHKLPVLSIDIS-FDSKMII 589 Query: 339 SSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHG----------------------- 375 +S D+ + +W L +S +D + F+ Sbjct: 590 TSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFEC 649 Query: 376 -----GHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 H +++ + + +++ S S D+ +++W+ E+ Sbjct: 650 IQKLYAHQSEVWALAVATDGGFVV-SSSHDHSIRIWEETED 689 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 42/219 (19%), Positives = 81/219 (36%), Gaps = 30/219 (13%) Query: 194 NGYLLSASDDHTICLWDINATPKEHRVIDAKN--IFTGHTAVVEDVAWHLLH--ESLFGS 249 + SA +D + +WDI ++ D A + + H L Sbjct: 39 GQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAV 96 Query: 250 VADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 309 D + +WD + + H A + L F+ ++ +GS D + +WDL Sbjct: 97 GYADGVIKVWDLMSKTV---LLNFNGHKAAITLLQFDGTGTRLI-SGSKDSNIIVWDL-V 151 Query: 310 LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPE 369 ++ L+ SHKD I W E L S+ D + +WDL + Sbjct: 152 GEVGLYKLRSHKDSITGF-WC-QGEDWLISTSKDGMIKLWDLKT--------------HQ 195 Query: 370 LLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 + H HT + + + ++ + D+ +++W++ Sbjct: 196 CIETHIAHTGECWGLAVKDD---LLITTGTDSQVKIWKL 231 Score = 84.8 bits (208), Expect = 7e-17, Method: Composition-based stats. Identities = 36/176 (20%), Positives = 64/176 (36%), Gaps = 28/176 (15%) Query: 139 QNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLL 198 ++ ++A + V+D GH+ L ++ L+ Sbjct: 89 KDTDLLAVGYADGVIKVWDLMSKTVLLN----------FNGHKAAITLLQFD-GTGTRLI 137 Query: 199 SASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMI 258 S S D I +WD+ +++ K+ TG + E S + D + + Sbjct: 138 SGSKDSNIIVWDLVGEVGLYKLRSHKDSITG---------FWCQGEDWLISTSKDGMIKL 188 Query: 259 WDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW--DLRNLKL 312 WD + T + T AHT E L+ + +L T D V +W D+ N K+ Sbjct: 189 WDLK---THQCIETHIAHTGECWGLAV---KDDLLITTGTDSQVKIWKLDIENDKM 238 Score = 73.7 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 42/176 (23%), Positives = 69/176 (39%), Gaps = 30/176 (17%) Query: 244 ESLFGSVADDQKLMIWDTRNNNTSKPSH---------TVDAHTAEVNCLSFNPYSEFILA 294 L S +D + IWD + + A AE L + ++ +LA Sbjct: 39 GQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTD-LLA 95 Query: 295 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKI 354 G AD + +WDL + + L+ F HK I +Q+ ++ S D + VWDL Sbjct: 96 VGYADGVIKVWDLMSKTVLLN-FNGHKAAITLLQFDGTGTRLI-SGSKDSNIIVWDLVGE 153 Query: 355 GEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 410 L+ H I+ F W E W+I S S+D ++++W + Sbjct: 154 VG--------------LYKLRSHKDSITGF-WCQGEDWLI-STSKDGMIKLWDLKT 193 >3F3P-A nrPDB Length = 351 Score = 101 bits (250), Expect = 1e-21, Method: Composition-based stats. Identities = 66/338 (19%), Positives = 111/338 (32%), Gaps = 60/338 (17%) Query: 122 EIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQ 181 H+ V+ Y V AT + + VF K S E S R H Sbjct: 5 PFDSGHDDLVHDVVYDFYGRHV-ATCSSDQHIKVFKLDKDTSNWELSDSW------RAHD 57 Query: 182 KEGYGLSW-NPNLNGYLLSASDDHTICLW--DINATPKEHRVIDAKNIFTGHTAVVEDVA 238 + W +P + SAS D T+ LW D + R + + V Sbjct: 58 SSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVK 117 Query: 239 WHLLHESL-FGSVADDQKLMIWD----------TRNNNTSKPSHTVDAHTAEVNCLSFNP 287 + H L + +D L ++D T + S H CLS+ P Sbjct: 118 FAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCP 177 Query: 288 Y--SEFILATGSADKTVALWDLRNLKLKLHS-FESHKDEIFQVQWSPHNE---TILASSG 341 S LA + ++ + ++ KL + + HK I + W+P ++A+ Sbjct: 178 SRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGC 237 Query: 342 TDRRLHVWDL--------------------------------SKIGEEQSTEDAEDGPPE 369 D R+ ++ + S E+ E + E Sbjct: 238 KDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVE 297 Query: 370 LLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 LL H H ++ SWN I+ S +D +++W+ Sbjct: 298 LLSEHDDHNGEVWSVSWNLTGT-ILSSAGDDGKVRLWK 334 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 25/156 (16%), Positives = 48/156 (30%), Gaps = 43/156 (27%) Query: 164 KPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGY---LLSASDDHTICLW----------- 209 + G+ +L GH+ +SW P++ + + + D I ++ Sbjct: 197 QRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLAS 256 Query: 210 ----------------DINATPKEHRVIDAKNIFTG------------HTAVVEDVAWHL 241 D++A + + K H V V+W+L Sbjct: 257 EESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNL 316 Query: 242 LHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHT 277 + S DD K+ +W +N K + A Sbjct: 317 TGT-ILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ 351 >5WBU-D nrPDB Length = 328 Score = 99.1 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 45/299 (15%), Positives = 99/299 (33%), Gaps = 28/299 (9%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEP-SGECQPDLRLRGHQKEG 184 H G R + TP ++ +H + S P + G K Sbjct: 31 AHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNI 90 Query: 185 YGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHE 244 + ++ + ++ + +D T +WD+ + + + I A + V H Sbjct: 91 ASVGFHED-GRWMYTGGEDCTARIWDLRSRNLQCQRIFQV------NAPINCVCLHPNQA 143 Query: 245 SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 304 L + IWD + ++ + + + +P + ++ A S + Sbjct: 144 ELIV-GDQSGAIHIWDLKTDHNEQLIPEPEV---SITSAHIDPDASYMAAVNST-GNCYV 198 Query: 305 WDLRNLK-------LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEE 357 W+L + +H Q ++SP + T+LA+ D+ +W S Sbjct: 199 WNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIWRTSNFSLM 257 Query: 358 QSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDE 416 P E + +++ + +I+ + S DN+ ++W + E Sbjct: 258 TELSIKSGNPGES------SRGWMWGCAFSGDSQYIV-TASSDNLARLWCVETGEIKRE 309 Score = 91.8 bits (226), Expect = 6e-19, Method: Composition-based stats. Identities = 43/250 (17%), Positives = 79/250 (31%), Gaps = 49/250 (19%) Query: 196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 255 L +A DHT+ W ++ V + V + S+ + Q Sbjct: 16 ILATAGYDHTVRFWQAHSGICTRTVQHQ-------DSQVNALEVTP-DRSMIAAAGY-QH 66 Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 315 + ++D +NN P + D + + F+ ++ TG D T +WDLR+ L+ Sbjct: 67 IRMYDLNSNN-PNPIISYDGVNKNIASVGFHEDGRWMY-TGGEDCTARIWDLRSRNLQCQ 124 Query: 316 SFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQ-------STEDAEDGPP 368 I V P+ ++ +H+WDL EQ S A P Sbjct: 125 RIFQVNAPINCVCLHPNQAELIV-GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPD 183 Query: 369 ELLFIH-----------------------------GGHTAKISDFSWNPNEPWIICSVSE 399 HT ++P+ ++ + S Sbjct: 184 ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST-LLATCSA 242 Query: 400 DNIMQVWQMA 409 D ++W+ + Sbjct: 243 DQTCKIWRTS 252 Score = 83.7 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 38/256 (14%), Positives = 81/256 (31%), Gaps = 35/256 (13%) Query: 131 VNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWN 190 + + + T ++D + +CQ ++ + + Sbjct: 90 IASVGFHEDGRW-MYTGGEDCTARIWDLRSR------NLQCQRIFQVNA---PINCVCLH 139 Query: 191 PNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTG-HTAVVEDVAWHLLHESLFGS 249 PN ++ I +WD+ E + + + T H S + Sbjct: 140 PNQAELIV-GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP---------DASYMAA 189 Query: 250 VADDQKLMIWDTRNNNTSK-----PSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 304 V +W+ + P + AHT F+P S +LAT SAD+T + Sbjct: 190 VNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST-LLATCSADQTCKI 248 Query: 305 WDLRNLKL--KLHSFESH-----KDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEE 357 W N L +L + + ++ +S + + ++ +D +W + + Sbjct: 249 WRTSNFSLMTELSIKSGNPGESSRGWMWGCAFS-GDSQYIVTASSDNLARLWCVETGEIK 307 Query: 358 QSTEDAEDGPPELLFI 373 + + L F Sbjct: 308 REYGGHQKAVVCLAFN 323 Score = 72.5 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 30/189 (15%), Positives = 64/189 (33%), Gaps = 23/189 (12%) Query: 243 HESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTV 302 + + D + W ++ + TV ++VN L P I A G + + Sbjct: 13 DPVILATAGYDHTVRFW---QAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY--QHI 67 Query: 303 ALWDLRNLKL-KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTE 361 ++DL + + S++ I V + + + G D +WDL + Sbjct: 68 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMY-TGGEDCTARIWDLRSRNLQCQRI 126 Query: 362 DAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDE--EPE 419 + P I+ +PN+ +I + + +W + + EPE Sbjct: 127 FQVNAP-------------INCVCLHPNQAELIV-GDQSGAIHIWDLKTDHNEQLIPEPE 172 Query: 420 IPASELETN 428 + + + Sbjct: 173 VSITSAHID 181 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 14/115 (12%), Positives = 31/115 (26%), Gaps = 30/115 (26%) Query: 332 HNETILASSGTDRRLHVWDLSK-----------------------------IGEEQSTED 362 + ILA++G D + W + D Sbjct: 12 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYD 71 Query: 363 AEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEE 417 P + + G I+ ++ + W+ + ED ++W + + Sbjct: 72 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMY-TGGEDCTARIWDLRSRNLQCQR 125 >5N4A-A nrPDB Length = 771 Score = 94.9 bits (234), Expect = 7e-20, Method: Composition-based stats. Identities = 39/234 (16%), Positives = 81/234 (34%), Gaps = 26/234 (11%) Query: 180 HQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW 239 H + + WN + L + SDD TI W++ P++ H V Sbjct: 13 HSELTAAVGWN--VWNELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKT 70 Query: 240 HLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSAD 299 +F D + I + T + +++ H L ++ LAT D Sbjct: 71 QAGGTDVFAVACTDGSVKI----LSRTGRVEKSIEGHKGACISLRWSYDGT-ALATAGED 125 Query: 300 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQS 359 +V +W RN L+ ++ ++ + W+ + + +G++ + Sbjct: 126 GSVKIWS-RNGMLRSTLAQAD-SPVYSIVWAYDCDQLCYCTGSNVVIK----------SL 173 Query: 360 TEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVY 413 + +A+ + H + W+P +I + ED +VW + Sbjct: 174 SSNAKQNAWK------AHDGVVLKVDWSP-INHLIITGGEDCKYKVWDSFGRLL 220 Score = 85.2 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 42/267 (15%), Positives = 82/267 (30%), Gaps = 44/267 (16%) Query: 127 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 186 H V+ + V A V + T K + GH+ Sbjct: 61 HWYPVSSKKTQAGGTDVFAVACTDGSVKILSRTGRVEKS-----------IEGHKGACIS 109 Query: 187 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 246 L W+ + L +A +D ++ +W N ++ + V + W + L Sbjct: 110 LRWSYD-GTALATAGEDGSVKIWSRNG--------MLRSTLAQADSPVYSIVWAYDCDQL 160 Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 + + + +++ + AH V + ++P + I+ TG D +WD Sbjct: 161 CYCTGSNVVIK-----SLSSNAKQNAWKAHDGVVLKVDWSPINHLII-TGGEDCKYKVWD 214 Query: 307 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 366 + L + V W+P E + A G + + + + Sbjct: 215 --SFGRLLFQSGLFDYPVTSVAWAPSGE-LFAVGGFN---------------TLQLCDRM 256 Query: 367 PPELLFIHGGHTAKISDFSWNPNEPWI 393 IH T I SW + + Sbjct: 257 GWAYSKIHLNDTGSIMTLSWTADSTQL 283 >3I2N-A nrPDB Length = 357 Score = 92.9 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 55/352 (15%), Positives = 119/352 (33%), Gaps = 36/352 (10%) Query: 75 HTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRA 134 H N+ + +P ++ G + G +++ +I + Sbjct: 12 HIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCG 71 Query: 135 RY--MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPN 192 + +AT ++ +++ P ++GH++ + Sbjct: 72 TFGATSLQQRYLATGDFGGNLHIWNLEAPEM---------PVYSVKGHKEIINAIDGIGG 122 Query: 193 LNGY-----LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW---HLLHE 244 L +++ S D T+ +WD ++ + VA+ + E Sbjct: 123 LGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQG--ENKRDCWTVAFGNAYNQEE 180 Query: 245 SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPY--SEFILATGSADKTV 302 + + D+ + ++D RN ++ + V L F+ S L S + Sbjct: 181 RVVCAGYDNGDIKLFDLRNMALRWETNIKNG----VCSLEFDRKDISMNKLVATSLEGKF 236 Query: 303 ALWDLRNLKL----KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL-----SK 353 ++D+R S ++HK ++QV+ P N + ++G LH+W Sbjct: 237 HVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRS 296 Query: 354 IGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQV 405 + + E G LL T IS W+P++ + S D ++V Sbjct: 297 KKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRV 348 Score = 60.2 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 29/211 (13%), Positives = 71/211 (33%), Gaps = 25/211 (11%) Query: 224 KNIFTGHTAVVEDVAWHLLHESLFGSVAD---DQKLMIWDTRNNNTSKPSHTVDAHTAEV 280 +I G V D W + +++ ++ + A + Sbjct: 11 AHIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKA--KPI 68 Query: 281 NCLSFNPYS--EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETI-- 336 C +F S + LATG + +W+L ++ ++S + HK+ I + Sbjct: 69 KCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEG 128 Query: 337 ---LASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWN---PNE 390 + + D + VWD + + + + G + ++ E Sbjct: 129 APEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENK---------RDCWTVAFGNAYNQE 179 Query: 391 PWIICSVSEDNIMQVWQMAENVYNDEEPEIP 421 ++C+ ++ ++++ + N+ E I Sbjct: 180 ERVVCAGYDNGDIKLFDL-RNMALRWETNIK 209 >4XFV-A nrPDB Length = 792 Score = 92.5 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 53/305 (17%), Positives = 110/305 (36%), Gaps = 58/305 (19%) Query: 143 VIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASD 202 ++A + ++D P +P G L+GH+ E + + P+ + +++SAS+ Sbjct: 33 IVAFGAG-KTIALWD----PIEPNNKGV---YATLKGHEAEVTCVRFVPDSD-FMVSASE 83 Query: 203 DHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTR 262 DH + +W ++ + ++ + ++ SL D + IW Sbjct: 84 DHHVKIWKFT----DYSHLQCIQTIQHYSKTIVALSALP---SLISVGCADGTISIW--- 133 Query: 263 NNNTSKPSHTVDAHTAEVNCLSFNP---------YSEFILATGSADKTVAL--WDLRNLK 311 + AH + F P +++LA G + V + + L + Sbjct: 134 -RQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSG 192 Query: 312 LK----LHSFESHKDEIFQVQWSPH---NETILASSGTDRRLHVW-----DLSKIGEEQS 359 ++ + E H+D + + + + +L S DR + +W DL EE S Sbjct: 193 IEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDS 252 Query: 360 TEDAEDGPPELLFIHG--------------GHTAKISDFSWNPNEPWIICSVSEDNIMQV 405 + + F GH IS W+ + ++ + + D + V Sbjct: 253 KKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATA-DTSLMV 311 Query: 406 WQMAE 410 W+ E Sbjct: 312 WEPDE 316 Score = 91.0 bits (224), Expect = 9e-19, Method: Composition-based stats. Identities = 58/345 (16%), Positives = 112/345 (32%), Gaps = 56/345 (16%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 HE EV R++P ++ + + + V ++ +T + Q ++ + K Sbjct: 61 GHEAEVTCVRFVP-DSDFMVSASEDHHVKIWKFTDY-------SHLQCIQTIQHYSKTIV 112 Query: 186 GLSWNPNLNGYLLS-ASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVE-DVAWHLLH 243 LS P+ L+S D TI +W N E + I G + ++ Sbjct: 113 ALSALPS----LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEK 168 Query: 244 ESLFGSVADDQKLMI--WDTRNNNTSKP--SHTVDAHTAEVNCLSFNPY---SEFILATG 296 + L + + I + ++ K ++ H V L+F +++L +G Sbjct: 169 KYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSG 228 Query: 297 SADKTVALW---------DLRNLKLKLHSFE-----------------------SHKDEI 324 S D+ + LW D KL H D I Sbjct: 229 SQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWI 288 Query: 325 FQVQWSPHNETILASSGTDRRLHVWDL-SKIGEEQSTEDAEDGPPELLFIHGGHTAKISD 383 +QW +LA + D L VW+ G + + + G + Sbjct: 289 SSLQWHESRLQLLA-ATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWS 347 Query: 384 FSWNPNEP-WIICSVSEDNIMQVWQMAENVYNDEEPEIPASELET 427 W +E + + ++W +N+ D+ I + + Sbjct: 348 CLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDV 392 Score = 87.9 bits (216), Expect = 7e-18, Method: Composition-based stats. Identities = 45/230 (19%), Positives = 91/230 (39%), Gaps = 33/230 (14%) Query: 204 HTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRN 263 TI LWD P E GH A V V + S ++D + IW + Sbjct: 40 KTIALWD----PIEPNNKGVYATLKGHEAEVTCVRFVP-DSDFMVSASEDHHVKIWKFTD 94 Query: 264 NNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW--DLRNLKLKLHSFESHK 321 + + T+ ++ + LS P +++ G AD T+++W +++N + L +H+ Sbjct: 95 YSHLQCIQTIQHYSKTIVALSALPS---LISVGCADGTISIWRQNIQNDEFGL----AHE 147 Query: 322 DEIFQVQWSP---------HNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLF 372 I + + P + +LA GT+ + + D+ ++ Sbjct: 148 FTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFI-------ASFILSDSGIEKCRVVA 200 Query: 373 IHGGHTAKISDFSWNPN---EPWIICSVSEDNIMQVWQMAENVYNDEEPE 419 GH + ++ +++CS S+D +++W++ N D+ E Sbjct: 201 ELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEE 250 Score = 73.3 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 42/256 (16%), Positives = 87/256 (33%), Gaps = 34/256 (13%) Query: 171 CQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDH-----TICLWDINATPKEHRVIDAKN 225 +L GH E L +P+ + SA + I ++ ++ K Sbjct: 552 WPEVEKLYGHGFEITCLDISPDQ-KLIASACRSNNVQNAVIRIFSTEN------WLEIKP 604 Query: 226 IFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIW--DTRNNNTSKPSHTVDAHTAEVNCL 283 H+ + + + + L SV D+K +W + +N HT + Sbjct: 605 ALPFHSLTITRLKFSKDGKFLL-SVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDA 663 Query: 284 SFNPYS-EFILATGSADKTVALWDLRNLKLKLHSFES---HKDEIFQVQWSPH---NETI 336 + P + T S DKTV +W + + E+ H + + + + Sbjct: 664 DWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKIL 723 Query: 337 LASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWN---PNEPWI 393 ++ + ++++ + E T+ ED P KI+ W+ N Sbjct: 724 ISVGLENGEIYLYSYTLGKFELITQLNEDITPA---------DKITRLRWSHLKRNGKLF 774 Query: 394 ICSVSEDNIMQVWQMA 409 + S D +++ +A Sbjct: 775 LGVGSSDLSTRIYSLA 790 Score = 72.5 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 49/306 (16%), Positives = 96/306 (31%), Gaps = 50/306 (16%) Query: 126 NHEGEVNRARYMPQN---ACVIATKTPSSDVLVF-------------DYTKHPSKPEPSG 169 HE V + Q ++ + + + ++ D K Sbjct: 204 GHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQY 263 Query: 170 ECQPDLRLR----------GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHR 219 + Q D LR GH L W+ + L A+ D ++ +W+ + T Sbjct: 264 KFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLA-ATADTSLMVWEPDETSGIWV 322 Query: 220 VI--------DAKNIFTGHTAVVEDVAWHLLHE-SLFGSVADDQKLMIWDTRNNNTSKPS 270 + TG + W F + +W T++N Sbjct: 323 CSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQR 382 Query: 271 HTVDAHTAEVNCLSFNPYSEFILATGSADKTVA-----LWDLRNLKLKLHSFES------ 319 + T +V ++++P E++LAT S D+T ++D K ++ ++ Sbjct: 383 LGISGATKDVTDIAWSPSGEYLLAT-SLDQTTRLFAPWIYDASGRKREIATWHEFSRPQI 441 Query: 320 HKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTA 379 H ++ V+ S G ++ L +DL K + E + T Sbjct: 442 HGYDMICVETVTDTR--FVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATV 499 Query: 380 KISDFS 385 + S Sbjct: 500 PVLGLS 505 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 34/210 (16%), Positives = 72/210 (34%), Gaps = 21/210 (10%) Query: 210 DINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK-----LMIWDTRNN 264 + + H + GH + + + L S + I+ T N Sbjct: 541 PMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQK-LIASACRSNNVQNAVIRIFSTENW 599 Query: 265 NTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD----LRNLKLKLHSFESH 320 KP+ H+ + L F+ +F+L+ D+ ALW+ +L+ + + H Sbjct: 600 LEIKPALPF--HSLTITRLKFSKDGKFLLSVC-RDRKWALWERNMEDNTFELRFKNEKPH 656 Query: 321 KDEIFQVQWSPHN-ETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTA 379 I+ W+P + ++ D+ + VW K + +A + + H + Sbjct: 657 TRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDS 716 Query: 380 KISDFSWNPNEPWIICSVSEDNIMQVWQMA 409 I E +I E+ + ++ Sbjct: 717 MIR-------EKILISVGLENGEIYLYSYT 739 Score = 65.2 bits (157), Expect = 6e-11, Method: Composition-based stats. Identities = 31/166 (18%), Positives = 60/166 (36%), Gaps = 15/166 (9%) Query: 270 SHTVDAHTAEVNCLSFNPYSEFILATGSADK----TVALWDLRNLKLKLHSFESHKDEIF 325 + H E+ CL +P + I + ++ + ++ N + H I Sbjct: 555 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 614 Query: 326 QVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFS 385 ++++S + L S DR+ +W+ + + P HT I D Sbjct: 615 RLKFS-KDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKP---------HTRIIWDAD 664 Query: 386 WNPNE-PWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETNTA 430 W P E + + S D ++VW+ + +D E + TA Sbjct: 665 WAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTA 710 Score = 54.8 bits (130), Expect = 8e-08, Method: Composition-based stats. Identities = 27/191 (14%), Positives = 72/191 (37%), Gaps = 20/191 (10%) Query: 127 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 186 H + R ++ ++ + + +++ + E + + H + + Sbjct: 609 HSLTITRLKF-SKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKP-----HTRIIWD 662 Query: 187 LSWNP-NLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLL--H 243 W P ++AS D T+ +W P + V++A HT V ++ H Sbjct: 663 ADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIK---HTKAVTAISIHDSMIR 719 Query: 244 ESLFGSVA-DDQKLMIWDT---RNNNTSKPSHTVDAHTAEVNCLSFNP---YSEFILATG 296 E + SV ++ ++ ++ + ++ + + ++ L ++ + L G Sbjct: 720 EKILISVGLENGEIYLYSYTLGKFELITQLNEDITP-ADKITRLRWSHLKRNGKLFLGVG 778 Query: 297 SADKTVALWDL 307 S+D + ++ L Sbjct: 779 SSDLSTRIYSL 789 >1PI6-A nrPDB Length = 615 Score = 92.2 bits (227), Expect = 4e-19, Method: Composition-based stats. Identities = 43/247 (17%), Positives = 85/247 (34%), Gaps = 25/247 (10%) Query: 173 PDLRLRGHQKEG-YGLSWNPNLN-GYLLSASDDHTICLWDINATPKEHRV-IDAKNIFTG 229 P ++ GH + ++P YL S + + +W + + V ++ K+ F Sbjct: 55 PVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQV 114 Query: 230 HTAVVEDVAWHLLHESLFGSV-ADDQK-LMI-WDTRNNNTSKPSHTVDAHTAEVNCLSFN 286 + D++W L D + I WD + V H+ +N Sbjct: 115 LAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD-----SGNSLGEVSGHSQRINACHLK 169 Query: 287 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHK--DEIFQVQWSPHNETILASSGTDR 344 T D +V + K HK + V++SP + + + G+DR Sbjct: 170 QSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDR 229 Query: 345 RLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQ 404 ++ +D + ED ++ I SW ++ +V D ++ Sbjct: 230 KISCFDGKSGEFLKYIEDDQEPV----------QGGIFALSWLDSQK--FATVGADATIR 277 Query: 405 VWQMAEN 411 VW + + Sbjct: 278 VWDVTTS 284 Score = 78.3 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 51/328 (15%), Positives = 107/328 (32%), Gaps = 45/328 (13%) Query: 105 EKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSK 164 + FG F S + H +N + + + + T D V Y P K Sbjct: 137 GRDNFGVFISWDSGNSLGEVSGHSQRIN--ACHLKQSRPMRSMTVGDDGSVVFYQGPPFK 194 Query: 165 PEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAK 224 S + ++P+ ++++ D I +D + + D + Sbjct: 195 FSASDRTHHKQ-----GSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQ 249 Query: 225 NIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSK--PSHTVDAHTAEVNC 282 G + ++W L F +V D + +WD + + +V Sbjct: 250 EPVQG---GIFALSW--LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGV 304 Query: 283 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGT 342 ++ + + S D T+ ++L + ++ L + H I + +P L S Sbjct: 305 VA---TGNGRIISLSLDGTLNFYELGHDEV-LKTISGHNKGITALTVNP-----LISGSY 355 Query: 343 DRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNI 402 D R+ W S +H H+ I + + S+S D+ Sbjct: 356 DGRIMEWSSSS-------------------MHQDHSNLIVSLDNS--KAQEYSSISWDDT 394 Query: 403 MQVWQMAENVYNDEEPEIPASELETNTA 430 ++V +P++ ++ + TA Sbjct: 395 LKV-NGITKHEFGSQPKVASANNDGFTA 421 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 43/336 (12%), Positives = 100/336 (29%), Gaps = 89/336 (26%) Query: 140 NACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLS 199 N V T + ++ G + + GH K L+ NP L+S Sbjct: 299 NQQVGVVATGNGRIISLSL-DGTLNFYELGHDEVLKTISGHNKGITALTVNP-----LIS 352 Query: 200 ASDDHTICLWDINA--------------------------------TPKEHRVIDAKNIF 227 S D I W ++ +H + Sbjct: 353 GSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVA 412 Query: 228 TGHTAVVEDVAWHLLHESLFGSVADD--QKLMIWDTRNNNTSKPSHTV----DAHTAEV- 280 + + V + + S D + + + + + ++ + +T +V Sbjct: 413 SANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVF 472 Query: 281 -------------------NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHK 321 + +S +P +I A G + L+DL++ ++K + Sbjct: 473 KLSDLEVSFDLKTPLRAKPSYISISPSETYI-AAGDVMGKILLYDLQSREVKTSRWAFRT 531 Query: 322 DEIFQVQWSPHNET---------ILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLF 372 +I + W P + ++A+ D + ++ + + P +++ Sbjct: 532 SKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKR-------------PMKIIK 578 Query: 373 IHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 H +++ W P + S D ++ W + Sbjct: 579 ALNAHKDGVNNLLW--ETPSTLVSSGADACIKRWNV 612 >5A9Q-2 nrPDB Length = 326 Score = 91.8 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 52/287 (18%), Positives = 99/287 (34%), Gaps = 41/287 (14%) Query: 127 HEG-EVNRARYMPQN-----ACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGH 180 H G V+ + P+ VI T ++D+ + +T + L GH Sbjct: 70 HHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDL------QDKNEYKVLEGH 123 Query: 181 QKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH 240 GL ++P + S SDDHT +W++ H F H+ V WH Sbjct: 124 TDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAH--------FVLHS-PGMSVCWH 174 Query: 241 LLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFIL-ATGSAD 299 + + +D + ++++ + + + F + A D Sbjct: 175 PEETFKLMVAEKNGTIRFYDLLAQ---QAILSLESEQVPLMSAHWCLKNTFKVGAVAGND 231 Query: 300 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQS 359 +WD+ + H D +WS +E + A++G ++ Sbjct: 232 WL--IWDITRSSYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKM----------ASQ 279 Query: 360 TEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 + G P+ + + G A S SW+ P +C + D+ + W Sbjct: 280 FQIHHLGHPQPILM--GSVAVGSGLSWHRTLP--LCVIGGDHKLLFW 322 Score = 66.7 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 26/152 (17%), Positives = 55/152 (36%), Gaps = 27/152 (17%) Query: 267 SKPSHTVDAHTAEVNCLSFNPYSEF-------ILATGSADKTVALW--DLRNLKLKLHSF 317 K T H V+ ++++P + T +AD + L+ DL++ K + Sbjct: 63 YKTLRTFH-HGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQD-KNEYKVL 120 Query: 318 ESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGH 377 E H D I + + P +AS D +W+L + H Sbjct: 121 EGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVL---------------H 165 Query: 378 TAKISDFSWNPNEPWIICSVSEDNIMQVWQMA 409 + + W+P E + + ++ ++ + + Sbjct: 166 SPGM-SVCWHPEETFKLMVAEKNGTIRFYDLL 196 Score = 57.1 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 28/152 (18%), Positives = 54/152 (35%), Gaps = 33/152 (21%) Query: 277 TAEVNCLSFNP----YSEFILATGSADKTVAL---------WDLRNLKLKLHSFESHKDE 323 V+ + FNP S ++A G + V + D+ ++ K H Sbjct: 16 EDYVHVVEFNPFENGDSGNLIAYGG-NNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVR 74 Query: 324 IFQVQWSPHNET-------ILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGG 376 + + WSP +S D ++ + ++ + G Sbjct: 75 VDGIAWSPETRLDSLPPVIKFCTSAADMKIRL------------FTSDLQDKNEYKVLEG 122 Query: 377 HTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 HT I+ ++P E I SVS+D+ ++W + Sbjct: 123 HTDFINGLVFDPKEGQEIASVSDDHTCRIWNL 154 Score = 49.0 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 43/233 (18%), Positives = 75/233 (32%), Gaps = 41/233 (17%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 H +N + P+ IA+ + +++ E H G Sbjct: 122 GHTDFINGLVFDPKEGQEIASVSDDHTCRIWNL-----------EGVQTAHFVLHS-PGM 169 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRV-IDAKNIFTGHTAVVEDVAWHLLHE 244 + W+P L+ A + TI +D+ A + + + + H W L + Sbjct: 170 SVCWHPEETFKLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAH--------WCLKNT 221 Query: 245 SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 304 G+VA + L IWD +S P + H ++ SE + AT +A Sbjct: 222 FKVGAVAGNDWL-IWDI--TRSSYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKMA- 277 Query: 305 WDLRNLKLKLHSFESHKDEIF--------QVQWSPHNETILASSGTDRRLHVW 349 + ++H H I + W L G D +L W Sbjct: 278 -----SQFQIHHL-GHPQPILMGSVAVGSGLSWHRTLP--LCVIGGDHKLLFW 322 >5BJS-A nrPDB Length = 605 Score = 90.6 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 46/322 (14%), Positives = 105/322 (32%), Gaps = 46/322 (14%) Query: 86 ASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNAC--- 142 A +LP F + ++ G GSV + E ++ P + Sbjct: 47 AEWELPRLRTSF---IFQDDYKYLGDDGSVSQDL---------AEFFDVKFYPYSPPGAP 94 Query: 143 -VIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPN---LNGYLL 198 V A + V+ P Q G++ W+ + L Sbjct: 95 PVFAATSKKHAVICRLTQTTDKDANPCEIIQLIRD-DGNEANCASC-WSKDPITDQPLLC 152 Query: 199 SASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMI 258 A ++ + ++++ GH + D+A + + S +DD + I Sbjct: 153 IAGNEGNVKVYNVTEG-------KLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRI 205 Query: 259 WDTRNNNTSKPSHTV---DAHTAEVNCLSFNPYSEFILATGSADKTVALW---DLRNLKL 312 W + +P + + H+ ++ ++F+ ++L + D+ + LW + N + Sbjct: 206 WSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVL-SAGHDQVINLWALPEFPNEHM 264 Query: 313 KL---------HSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDA 363 ++ S E H + + V + + + IL+ + + + +W + + Sbjct: 265 EIPIVIYYPHFSSSEIHNNLVDCVAF--YGDLILSRACHEDTIVLWRIEGFSSDDPIPGP 322 Query: 364 EDGPPELLFIHGGHTAKISDFS 385 D P + S Sbjct: 323 LDAPTPTDMTKQTRSYFTPTVS 344 Score = 80.2 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 29/172 (16%), Positives = 70/172 (40%), Gaps = 14/172 (8%) Query: 243 HESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTV 302 + L ++ + +++ K T+ H +N L+ +P + +I+A+ S D T+ Sbjct: 147 DQPLLCIAGNEGNVKVYNVTE---GKLYRTLVGHGGGINDLATSPANPYIIASASDDTTI 203 Query: 303 ALWDL-----RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEE 357 +W L + + + E H ++ V + + +L S+G D+ +++W L + E Sbjct: 204 RIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVL-SAGHDQVINLWALPEFPNE 262 Query: 358 QSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDN-IMQVWQM 408 P H + ++ + +I S + + +W++ Sbjct: 263 HMEIPIVIYYPHFS-SSEIHNNLVDCVAFYGD---LILSRACHEDTIVLWRI 310 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 21/117 (17%), Positives = 50/117 (42%), Gaps = 20/117 (17%) Query: 309 NLKLKLHSFESHKDEIFQVQ-WSPH---NETILASSGTDRRLHVWDLSKIGEEQSTEDAE 364 N + +E WS ++ +L +G + + V+++++ ++ Sbjct: 119 NPCEIIQLIRDDGNEANCASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLV--- 175 Query: 365 DGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIP 421 GH I+D + +P P+II S S+D +++W +A ++++P + Sbjct: 176 -----------GHGGGINDLATSPANPYIIASASDDTTIRIWSLAP--EHEKQPCVC 219 >4U1E-I nrPDB Length = 347 Score = 87.9 bits (216), Expect = 8e-18, Method: Composition-based stats. Identities = 50/342 (14%), Positives = 111/342 (32%), Gaps = 78/342 (22%) Query: 119 IEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLR 178 ++ HE + + +Y + ++ + + S V+ L Sbjct: 1 MKAIKLTGHERPLTQVKYN-KEGDLLFSCSKDSSASVWYSLNGERLG----------TLD 49 Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 GH + + + Y ++ S D++I LWD++ V+ V Sbjct: 50 GHTGTIWSIDVD-CFTKYCVTGSADYSIKLWDVSNGQCVATWKSPV--------PVKRVE 100 Query: 239 WHLLHESLFGSVAD----DQKLMIWDTRNNNTS--------KPSHTVDAHT--AEVNCLS 284 + + + + I++ ++ + +P H + H Sbjct: 101 FSPCGNYFLAILDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAG 160 Query: 285 FNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDR 344 ++ ++I+A G D ++ +D+ N + S + H+ I +Q+SP + SS D Sbjct: 161 WSTKGKYIIA-GHKDGKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSS-RDT 218 Query: 345 RLHVWDLSKI-------------------------------GEEQSTEDAEDGPPELLFI 373 + D+S + ++ +T A +G E F Sbjct: 219 NSFLVDVSTLQVLKKYETDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFY 278 Query: 374 H----------GGHTAKISDFSWNPNEPWIICSVSEDNIMQV 405 H GH ++ + +P S ED +++ Sbjct: 279 HKIFEEEIGRVQGHFGPLNTVAISPQGTSY-ASGGEDGFIRL 319 Score = 45.2 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 20/95 (21%), Positives = 35/95 (36%), Gaps = 16/95 (16%) Query: 317 FESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGG 376 H+ + QV+++ + +L S D VW S GE T D G Sbjct: 6 LTGHERPLTQVKYNKEGD-LLFSCSKDSSASVW-YSLNGERLGTLD-------------G 50 Query: 377 HTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 HT I + + + S D +++W ++ Sbjct: 51 HTGTIWSIDVDCFTKY-CVTGSADYSIKLWDVSNG 84 >5WYJ-BE nrPDB Length = 939 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 57/344 (16%), Positives = 132/344 (38%), Gaps = 55/344 (15%) Query: 116 CGKIEIEIKINHE--GEVNRARYMPQNACVIATKT-PSSDVLVFDYTKHPSKPEPSGECQ 172 +I + I+ E G V +A ++ ++ + S VFD + + + Sbjct: 281 RSRIHVLKNIHRESYGGVTQATFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPP 340 Query: 173 PDLRLRG-HQKEGYGLSWNPNLNGYLLSASDDHTICLW------DINATPKEHRVIDAKN 225 LR RG H + +++ + + ++LSAS D + LW D + R+ ++ Sbjct: 341 RYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRS--LWSFSLRKDAQSQEMSQRLHKKQD 398 Query: 226 IFTGHTAVVED-----VAWHLLH------ESLFGSVADDQKLMIWDTRNNNTSKPSHTVD 274 + ++ VA + + E++ + D++ WD RN + + Sbjct: 399 GGRVGGSTIKSKFPEIVALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFD-T 457 Query: 275 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE 334 V ++ + F GS++ ++ ++++++ L+ ++ HK + + N Sbjct: 458 TDDGFVKSVAMSQCGNFGFI-GSSNGSITIYNMQSGILR-KKYKLHKRAVTGISLDGMNR 515 Query: 335 TILASSGTDRRLHVWDLSKIG---------------------------EEQSTEDAEDGP 367 ++ S G D + +D +K ++ S + Sbjct: 516 KMV-SCGLDGIVGFYDFNKSTLLGKLKLDAPITAMVYHRSSDLFALALDDLSIVVIDAVT 574 Query: 368 PELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 ++ GH+ +I+ F ++P WI+ S S D+ ++ W + Sbjct: 575 QRVVRQLWGHSNRITAFDFSPEGRWIV-SASLDSTIRTWDLPTG 617 Score = 79.8 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 31/170 (18%), Positives = 67/170 (39%), Gaps = 16/170 (9%) Query: 180 HQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW 239 H++ G+S + +N ++S D + +D N + ++ A + + + Sbjct: 501 HKRAVTGISLD-GMNRKMVSCGLDGIVGFYDFNKSTLLGKLKL--------DAPITAMVY 551 Query: 240 HLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSAD 299 H LF DD +++ D T + + H+ + F+P +I+ + S D Sbjct: 552 H-RSSDLFALALDDLSIVVID---AVTQRVVRQLWGHSNRITAFDFSPEGRWIV-SASLD 606 Query: 300 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 T+ WDL + V++SP+ + + + T + +W Sbjct: 607 STIRTWDLPTGGCIDGIIVDNVA--TNVKFSPNGDLLATTHVTGNGICIW 654 Score = 65.2 bits (157), Expect = 6e-11, Method: Composition-based stats. Identities = 41/333 (12%), Positives = 85/333 (25%), Gaps = 78/333 (23%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDL--------RL 177 H + + + + + + + F K E S + Sbjct: 348 GHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTI 407 Query: 178 RGHQKEGYGLSW-NPNLNGY--LLSASDDHTI-CLWDINATPKEHRVIDAKNIFTGHTAV 233 + E L+ N + + +++A D WD+ D + Sbjct: 408 KSKFPEIVALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTD-----DGF 462 Query: 234 VEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFIL 293 V+ VA F + + + I++ ++ K H V +S + + ++ Sbjct: 463 VKSVAMSQCGNFGFI-GSSNGSITIYNMQSGILRKKYKL---HKRAVTGISLDGMNRKMV 518 Query: 294 ATGSADKTVALWDLRNLKLK---------------------------------------- 313 + D V +D L Sbjct: 519 -SCGLDGIVGFYDFNKSTLLGKLKLDAPITAMVYHRSSDLFALALDDLSIVVIDAVTQRV 577 Query: 314 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFI 373 + H + I +SP I+ S+ D + WDL G Sbjct: 578 VRQLWGHSNRITAFDFSPEGRWIV-SASLDSTIRTWDLPTGGCIDGIIVDNVATN----- 631 Query: 374 HGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 ++PN + + N + +W Sbjct: 632 ----------VKFSPNGDLLATTHVTGNGICIW 654 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 21/108 (19%), Positives = 39/108 (36%), Gaps = 9/108 (8%) Query: 167 PSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNI 226 + + +L GH ++P +++SAS D TI WD+ +I Sbjct: 571 DAVTQRVVRQLWGHSNRITAFDFSP-EGRWIVSASLDSTIRTWDLPTGGCIDGIIV---- 625 Query: 227 FTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVD 274 V +V + + L + + IW R + + T+D Sbjct: 626 ----DNVATNVKFSPNGDLLATTHVTGNGICIWTNRAQFKTVSTRTID 669 Score = 48.2 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 32/183 (17%), Positives = 76/183 (41%), Gaps = 13/183 (7%) Query: 245 SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 304 + ++++++ R K T+ + ++ LSF L+ G++ + Sbjct: 219 DIIALGTVTGEVIMFNMRK---GKRIRTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIF 275 Query: 305 WDLRNLKLKLHSFES-HK---DEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 360 +DL + + ++H ++ H+ + Q + + + I+ +SG D L + + Q + Sbjct: 276 YDL-DRRSRIHVLKNIHRESYGGVTQATFL-NGQPIIVTSGGDNSLKEY-VFDPSLSQGS 332 Query: 361 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEI 420 D PP L GGH+ S ++ ++ + S S+D +W + + + E+ Sbjct: 333 GDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRS--LWSFSLR-KDAQSQEM 389 Query: 421 PAS 423 Sbjct: 390 SQR 392 Score = 41.7 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 43/287 (14%), Positives = 82/287 (28%), Gaps = 56/287 (19%) Query: 142 CVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSAS 201 +IA T + +V++F+ K ++ Q LS+ + + +L + Sbjct: 219 DIIALGTVTGEVIMFNMRKGKR----------IRTIKIPQSRISSLSFRTDGSSHLSVGT 268 Query: 202 DDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDT 261 + +D++ + H + + G V + + S D L Sbjct: 269 SSGDLIFYDLDRRSRIHVLKNIHRESYG---GVTQATFLNGQPIIVTSGG-DNSLK---- 320 Query: 262 RNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHK 321 V F+P L+ GS D V L S H Sbjct: 321 ----------------EYV----FDPS----LSQGSGDVVV------QPPRYLRSRGGHS 350 Query: 322 DEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGE----EQSTEDAEDGPPELLFIHGGH 377 + ++ + S+ DR L + L K + Q +DG Sbjct: 351 QPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSK 410 Query: 378 TAKISDFSW--NPNEPW--IICSVSEDNIMQVWQMAENVYNDEEPEI 420 +I + W II + ++ + W M + Sbjct: 411 FPEIVALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDT 457 >5K0Y-T nrPDB Length = 329 Score = 85.2 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 42/328 (12%), Positives = 101/328 (30%), Gaps = 72/328 (21%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 HE + + +Y D+L S + GH + Sbjct: 8 GHERSITQIKY-----------NREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVW 56 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 + + + L + S D++ LWD + + + V + Sbjct: 57 CVDADWDTKHVL-TGSADNSCRLWDCETGKQLALLKT--------NSAVRTCGFDFGGNI 107 Query: 246 LFGSV----ADDQKLMIWDTRNN---NTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSA 298 + S + +D R+ + ++P + + +++ + P E I+A G Sbjct: 108 IMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIA-GHE 166 Query: 299 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQ 358 + + ++ ++ ++ + H +I +Q S T+ ++ D ++D + + ++ Sbjct: 167 SGELNQYSAKSGEVLVNV-KEHSRQINDIQLS-REMTMFVTASKDNTAKLFDSTTLEHQK 224 Query: 359 STEDAED-------------------------------GPPELLFIH----------GGH 377 + G E F H GH Sbjct: 225 TFRTEPPRELAALSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGH 284 Query: 378 TAKISDFSWNPNEPWIICSVSEDNIMQV 405 I+ +++P+ S ED +++ Sbjct: 285 FGPINSVAFHPDGKSY-SSGGEDGYVRI 311 Score = 60.2 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 39/222 (17%), Positives = 76/222 (34%), Gaps = 46/222 (20%) Query: 227 FTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFN 286 GH + + ++ + LF +VA D + +W + + T HT V C+ + Sbjct: 6 LQGHERSITQIKYNREGDLLF-TVAKDPIVNVW---YSVNGERLGTYMGHTGAVWCVDAD 61 Query: 287 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS----GT 342 ++ +L TGSAD + LWD K +L ++ + + I+ S+ G Sbjct: 62 WDTKHVL-TGSADNSCRLWDCETGK-QLALLKT-NSAVRTCGFDFGGNIIMFSTDKQMGY 118 Query: 343 DRRLHVWDLSKIGEEQSTE--------------------------DAEDGPPELLFIHGG 376 + +DL + + E E G G Sbjct: 119 QCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSG 178 Query: 377 --------HTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 410 H+ +I+D + + + S+DN +++ Sbjct: 179 EVLVNVKEHSRQINDIQLSREMT-MFVTASKDNTAKLFDSTT 219 Score = 60.2 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 33/271 (12%), Positives = 78/271 (28%), Gaps = 34/271 (12%) Query: 94 DAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDV 153 DA +D H + C + + V + ++ + Sbjct: 59 DADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGY 118 Query: 154 LVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINA 213 F P +P +++ + + W P L +++ + + + + Sbjct: 119 QCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGP-LGECIIAGHESGELNQYSAKS 177 Query: 214 TPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTV 273 V + H+ + D+ +F + + D ++D+ K T Sbjct: 178 GEVLVNVKE-------HSRQINDIQLSREMT-MFVTASKDNTAKLFDSTTLEHQKTFRTE 229 Query: 274 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFE--------------- 318 + +P E ++ G + D+ ++ FE Sbjct: 230 PPRELA----ALSPNYEHVVVGGGQEAM----DVTTTSTRIGKFEARFFHLAFEEEFGRV 281 Query: 319 -SHKDEIFQVQWSPHNETILASSGTDRRLHV 348 H I V + P ++ +S G D + + Sbjct: 282 KGHFGPINSVAFHPDGKSY-SSGGEDGYVRI 311 Score = 48.2 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 37/95 (38%), Gaps = 16/95 (16%) Query: 317 FESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGG 376 + H+ I Q++++ + +L + D ++VW S GE T G Sbjct: 6 LQGHERSITQIKYNREGD-LLFTVAKDPIVNVW-YSVNGERLGTYM-------------G 50 Query: 377 HTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 HT + + + ++ + S DN ++W Sbjct: 51 HTGAVWCVDADWDTKHVL-TGSADNSCRLWDCETG 84 Score = 42.5 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 21/133 (15%), Positives = 42/133 (31%), Gaps = 9/133 (6%) Query: 79 EQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMP 138 +++ I +QL E F + DN F +E + E A P Sbjct: 185 KEHSRQINDIQLSREMTMFVTASKDNTAKLFDS-----TTLEHQKTFRTEPPRELAALSP 239 Query: 139 QNACVIATKT---PSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNG 195 V+ K ++ + R++GH ++++P+ Sbjct: 240 NYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKS 299 Query: 196 YLLSASDDHTICL 208 Y S +D + + Sbjct: 300 Y-SSGGEDGYVRI 311 >5OQL-X nrPDB Length = 630 Score = 85.2 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 51/361 (14%), Positives = 103/361 (28%), Gaps = 80/361 (22%) Query: 128 EGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQ--------------- 172 G V P A T T + + P P + Sbjct: 170 SGTVTSVAVCPPYAY---TTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKPPAPPKKRPER 226 Query: 173 -----------PDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVI 221 D +GH K + + + ++++ D + +++ + Sbjct: 227 ICFAKADARKANDKTYQGHLKAPLVVKASQD-GKFVVTGGADKRLVVYN-------AADL 278 Query: 222 DAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVN 281 FT H V +A+ + S + D+ + +W T+ H E+ Sbjct: 279 KPIKAFTQHRDAVTGLAFR-RGTNQLYSCSKDRTVKVWSLDELAY---VETLFGHQDEIL 334 Query: 282 CLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES---------------------- 319 + E ++ G+ D+T W + + Sbjct: 335 DID-ALGQERCVSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAA 393 Query: 320 HKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTA 379 H+ + +V + + + + L +W + + A P + Sbjct: 394 HEGSMDRVAMIDDD--MFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDY-SAD 450 Query: 380 KISDFSWNP-----------NEPW--IICSVSEDNIMQVWQMAENVYNDEEPEIPASELE 426 +I D S P P+ +I S S D ++VW+++E+ E I E Sbjct: 451 EIPDPSIIPAPQPRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDKRKLEAVGILGVGSE 510 Query: 427 T 427 T Sbjct: 511 T 511 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 16/112 (14%), Positives = 38/112 (33%), Gaps = 20/112 (17%) Query: 122 EIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDY--TKHPSKPEPSGECQPDLRLRG 179 HEG ++R + + + T + + D+ ++ K + +P ++L Sbjct: 389 PASAAHEGSMDRVAMI--DDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLED 446 Query: 180 HQKE---------------GYGLSWNPNLNGYLLSASDDHTICLWDINATPK 216 + + L P + + S S D I +W ++ + Sbjct: 447 YSADEIPDPSIIPAPQPRGITALRTLP-YSDLIFSGSWDGCIRVWRLSEDKR 497 >4OWR-A nrPDB Length = 339 Score = 82.5 bits (202), Expect = 4e-16, Method: Composition-based stats. Identities = 30/131 (22%), Positives = 55/131 (41%), Gaps = 15/131 (11%) Query: 183 EGYGLSWNPNL--NGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH 240 LS++P +L++ S + + W++ + + HT V DV W Sbjct: 12 SIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQM-----HTGPVLDVCWS 66 Query: 241 LLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSF--NPYSEFILATGSA 298 +F + + D+ +WD +N + + H A V + + P ++ TGS Sbjct: 67 DDGSKVF-TASCDKTAKMWDLSSNQAIQ----IAQHDAPVKTIHWIKAPNYSCVM-TGSW 120 Query: 299 DKTVALWDLRN 309 DKT+ WD R+ Sbjct: 121 DKTLKFWDTRS 131 Score = 80.6 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 54/328 (16%), Positives = 115/328 (35%), Gaps = 77/328 (23%) Query: 119 IEIEIKINHEGEVNRARYMPQN--ACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLR 176 ++IE+ + + + + P + + ++DV ++ + SG+ P + Sbjct: 1 MDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEV-------QDSGQTIPKAQ 53 Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 236 + H + W+ + + +AS D T +WD+++ H A V+ Sbjct: 54 -QMHTGPVLDVCWS-DDGSKVFTASCDKTAKMWDLSSNQ--------AIQIAQHDAPVKT 103 Query: 237 VAW-HLLHESLFGSVADDQKLMIWDTRNNN---------------------------TSK 268 + W + S + + D+ L WDTR++N Sbjct: 104 IHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGL 163 Query: 269 PSHTVDAHTAEVN-----------CLSFNPYSEFI---LATGSADKTVALW--DLRNLKL 312 + ++ +E C++ + A GS + VA+ + N Sbjct: 164 IVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAK 223 Query: 313 KLHSFESHKD------------EIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 360 +F+ H+ + + + P + T LA+ G+D R WD + +++ Sbjct: 224 DNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGT-LATVGSDGRFSFWDKDARTKLKTS 282 Query: 361 EDAEDGPPELLFIHGGHT-AKISDFSWN 387 E + F H G+ A S + W+ Sbjct: 283 EQLDQPISACCFNHNGNIFAYASSYDWS 310 Score = 64.8 bits (156), Expect = 7e-11, Method: Composition-based stats. Identities = 29/139 (20%), Positives = 51/139 (36%), Gaps = 22/139 (15%) Query: 278 AEVNCLSFNPYS--EFILATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWSPHNE 334 + CLSF+P + L GS V W++++ + + + H + V WS Sbjct: 11 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGS 70 Query: 335 TILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSW--NPNEPW 392 + +S D+ +WDLS Q + H A + W PN Sbjct: 71 KVFTASC-DKTAKMWDLSSNQAIQIAQ---------------HDAPVKTIHWIKAPN-YS 113 Query: 393 IICSVSEDNIMQVWQMAEN 411 + + S D ++ W + Sbjct: 114 CVMTGSWDKTLKFWDTRSS 132 Score = 52.1 bits (123), Expect = 5e-07, Method: Composition-based stats. Identities = 17/110 (15%), Positives = 36/110 (32%), Gaps = 19/110 (17%) Query: 322 DEIFQVQWSPHN--ETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTA 379 D I + +SP L + + W++ G+ HT Sbjct: 11 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQM------------HTG 58 Query: 380 KISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETNT 429 + D W+ + + + S D ++W ++ N + +I + T Sbjct: 59 PVLDVCWSDDGSKVF-TASCDKTAKMWDLSSN----QAIQIAQHDAPVKT 103 >5YZG-2 nrPDB Length = 646 Score = 82.1 bits (201), Expect = 5e-16, Method: Composition-based stats. Identities = 52/287 (18%), Positives = 99/287 (34%), Gaps = 33/287 (11%) Query: 135 RYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLN 194 R++ V AT VL F+ + P S R H+ + Sbjct: 49 RWVGPLP-VEATLAKKRKVLEFERVYLDNLPSAS----MYERSYMHRDVITHVVCT--KT 101 Query: 195 GYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQ 254 ++++AS D + W K I+ F H V+E +A LF SV DD+ Sbjct: 102 DFIITASHDGHVKFW-----KKIEEGIEFVKHFRSHLGVIESIAVSSEGA-LFCSVGDDK 155 Query: 255 KLMIWDTRNNNTSKPSHT--VDAHTAEVNCLSFNPYSEFILATGSADKT--VALWDLRNL 310 + ++D N + + C P S T + ++D R Sbjct: 156 AMKVFDVVNFDMINMLKLGYFPGQCEWIYC----PGDAISSVAASEKSTGKIFIYDGRGD 211 Query: 311 KLKLHSFES-HKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPE 369 LH F+ H + Q++ +P + ++ SS + W G + ++ E Sbjct: 212 NQPLHIFDKLHTSPLTQIRLNPVYKAVV-SSDKSGMIEYW----TGPPHEYKFPKNVNWE 266 Query: 370 L-----LFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 L+ A + ++P+ I ++ D +++++ Sbjct: 267 YKTDTDLYEFAKCKAYPTSVCFSPDGKK-IATIGSDRKVRIFRFVTG 312 Score = 32.1 bits (71), Expect = 0.50, Method: Composition-based stats. Identities = 19/152 (12%), Positives = 40/152 (26%), Gaps = 38/152 (25%) Query: 136 YMPQNAC--VIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNL 193 Y P +A V A++ + + ++D + H + NP Sbjct: 184 YCPGDAISSVAASEKSTGKIFIYDGRGDNQPLHIFDKL--------HTSPLTQIRLNPV- 234 Query: 194 NGYLLSASDDHTICL-----------------WDINATPKEHRVIDAKNIFTGHTAVVED 236 Y S D + + W+ + K A Sbjct: 235 --YKAVVSSDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFAKCK-------AYPTS 285 Query: 237 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSK 268 V + + ++ D+K+ I+ + Sbjct: 286 VCFSPDGKK-IATIGSDRKVRIFRFVTGKLMR 316 >3ACP-A nrPDB Length = 417 Score = 81.4 bits (199), Expect = 7e-16, Method: Composition-based stats. Identities = 54/353 (15%), Positives = 124/353 (35%), Gaps = 49/353 (13%) Query: 57 VTKQDGKDYSVHRLIL-GTHTSDEQNHLLI--ASVQLPSEDAQFDGSHYDNEKGEFGGFG 113 + DG D+ + +I G+ ++ + A +Q+ F Sbjct: 70 KARLDGHDFLFNTIIRDGSKMLKRADYTAVDTAKLQMRRFILGTTEGDIKVLDSNF---- 125 Query: 114 SVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQP 173 ++ EI H E+ + ++ P +I++ + + ++ + Sbjct: 126 ----NLQREIDQAHVSEITKLKFFPSGEALISS-SQDMQLKIWSVKDGSN---------- 170 Query: 174 DLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWD---------INATPKEHRVIDAK 224 L GH+ ++ + +LSAS D TI LW+ N H +++ Sbjct: 171 PRTLIGHRATVTDIAII-DRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSI 229 Query: 225 NIFTGHTAVVEDVAWHLLHESLFGS-------VADDQKLMIWDTRNNNTSKPSHTVDAHT 277 +F G + +++ + FG+ + + + + + T Sbjct: 230 ALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKE--QTIQLPSKFT 287 Query: 278 AEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKD-EIFQVQWSPHNETI 336 N L+ + + + G + +A WDLR+ + + F ++ I V ++ + Sbjct: 288 CSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFA--AGAL 345 Query: 337 LASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPN 389 SSG D + + D+ E + + P L+ + ++S F + + Sbjct: 346 FVSSGFDTSIKL-DIISDPESERPAIEFETPTFLVS----NDDEVSQFCYVSD 393 Score = 67.9 bits (164), Expect = 7e-12, Method: Composition-based stats. Identities = 22/132 (16%), Positives = 51/132 (38%), Gaps = 13/132 (9%) Query: 274 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHN 333 AH +E+ L F P E ++++ S D + +W +++ + H+ + + Sbjct: 133 QAHVSEITKLKFFPSGEALISS-SQDMQLKIWSVKDGSNP-RTLIGHRATVTDIAIIDRG 190 Query: 334 ETILASSGTDRRLHVWDLSKIGEEQST---EDAEDGPPELLFI-------HGGHTAKISD 383 +L S+ D + +W+ + E+ DG + H T+K ++ Sbjct: 191 RNVL-SASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEISTSKKNN 249 Query: 384 FSWNPNEPWIIC 395 + ++I Sbjct: 250 LEFGTYGKYVIA 261 Score = 64.8 bits (156), Expect = 7e-11, Method: Composition-based stats. Identities = 26/123 (21%), Positives = 51/123 (41%), Gaps = 19/123 (15%) Query: 290 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 FIL T D + + D N L+ ++H EI ++++ P E ++ SS D +L +W Sbjct: 108 RFILGTTEGD--IKVLD-SNFNLQREIDQAHVSEITKLKFFPSGEALI-SSSQDMQLKIW 163 Query: 350 DLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMA 409 + ++ GH A ++D + ++ S S D +++W+ Sbjct: 164 SVKDGSNPRTLI--------------GHRATVTDIAIIDRGRNVL-SASLDGTIRLWECG 208 Query: 410 ENV 412 Sbjct: 209 TGT 211 >6CB1-s nrPDB Length = 569 Score = 80.6 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 42/234 (17%), Positives = 86/234 (36%), Gaps = 30/234 (12%) Query: 181 QKEGYGLSWNPNLNGYLLSA---SDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDV 237 +K LSW+ Y ++ S + ++ + ++ + +K ++ D Sbjct: 356 KKTVKKLSWHRK-GDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSK-------GIIMDA 407 Query: 238 AWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGS 297 +H LF + + I+D K + ++ + +P + ++A+ S Sbjct: 408 KFHPFKPQLFVC--SQRYVRIYDLSQQILVK---KLLPGARWLSKIDIHPRGDNLIAS-S 461 Query: 298 ADKTVALW-DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGE 356 DK V LW DL + H+ + V + + +S+ D +HV+ + + Sbjct: 462 FDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIHVFHATVYDD 519 Query: 357 EQSTEDAEDGPPELLFIHGGH----TAKISDFSWNPNEPWIICSVSEDNIMQVW 406 L GH + + D W+P E W+ S DN ++W Sbjct: 520 MMKNPMIV-----PLKKLTGHKVINSLGVLDAIWHPREAWLF-SAGADNTARLW 567 Score = 60.6 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 60/380 (15%), Positives = 113/380 (29%), Gaps = 102/380 (26%) Query: 124 KINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLR----G 179 K+ GE R R+ +A + + + + + P P P +R G Sbjct: 138 KVPGYGESIRERFERSLDLYLAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAG 197 Query: 180 HQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW 239 H+ + LS +P +L + SDD T+ +W+I + +R + +E + W Sbjct: 198 HKGKVRTLSIDP-SGLWLATGSDDGTVRVWEILTGREVYRT-TLIDDEENPDYHIECIEW 255 Query: 240 HLLHESLFGSVADDQKLMI-------WDTRNNNTSKPSHTV------------------- 273 + + +VA + + + +D NN +K Sbjct: 256 NPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENG 315 Query: 274 DAHTAEVN----------CLSFNPYSEF-----ILATGSADKTVA--LW----------- 305 D N +N S+ I T S KTV W Sbjct: 316 DGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQ 375 Query: 306 -DLRNLKLKLHSFESH---------KDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIG 355 D N + +H H K I ++ P + S R + ++DLS+ Sbjct: 376 PDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCS--QRYVRIYDLSQQI 433 Query: 356 EEQSTEDAEDGPPELLFIHGG-----------------------------HTAKISDFSW 386 + ++ G H + ++ Sbjct: 434 LVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNF 493 Query: 387 NPNEPWIICSVSEDNIMQVW 406 + P + S ++D + V+ Sbjct: 494 HKKLP-LFSSAADDGTIHVF 512 Score = 58.3 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 32/138 (23%), Positives = 54/138 (39%), Gaps = 18/138 (13%) Query: 130 EVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW 189 +++ P+ +IA+ + VL D + P LR H+K +++ Sbjct: 444 WLSKIDIHPRGDNLIAS-SFDKRVLWHDLDLAST---------PYKTLRYHEKAVRSVNF 493 Query: 190 NPNLNGYLLSASDDHTICLW--DINATPKEHRVIDAKNIFTGHTAV----VEDVAWHLLH 243 + L SA+DD TI ++ + ++ +I TGH + V D WH Sbjct: 494 HKKL-PLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPRE 552 Query: 244 ESLFGSVADDQKLMIWDT 261 LF S D +W T Sbjct: 553 AWLF-SAGADNTARLWTT 569 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 17/69 (24%), Positives = 29/69 (42%), Gaps = 1/69 (1%) Query: 356 EEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYND 415 E S +D P I+ GH K+ S +P+ W+ + S+D ++VW++ Sbjct: 177 ELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWL-ATGSDDGTVRVWEILTGREVY 235 Query: 416 EEPEIPASE 424 I E Sbjct: 236 RTTLIDDEE 244 >6C0F-s nrPDB Length = 807 Score = 80.6 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 42/234 (17%), Positives = 86/234 (36%), Gaps = 30/234 (12%) Query: 181 QKEGYGLSWNPNLNGYLLSA---SDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDV 237 +K LSW+ Y ++ S + ++ + ++ + +K ++ D Sbjct: 594 KKTVKKLSWHRK-GDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSK-------GIIMDA 645 Query: 238 AWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGS 297 +H LF + + I+D K + ++ + +P + ++A+ S Sbjct: 646 KFHPFKPQLFVC--SQRYVRIYDLSQQILVK---KLLPGARWLSKIDIHPRGDNLIAS-S 699 Query: 298 ADKTVALW-DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGE 356 DK V LW DL + H+ + V + + +S+ D +HV+ + + Sbjct: 700 FDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIHVFHATVYDD 757 Query: 357 EQSTEDAEDGPPELLFIHGGH----TAKISDFSWNPNEPWIICSVSEDNIMQVW 406 L GH + + D W+P E W+ S DN ++W Sbjct: 758 MMKNPMIV-----PLKKLTGHKVINSLGVLDAIWHPREAWLF-SAGADNTARLW 805 Score = 60.2 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 60/380 (15%), Positives = 113/380 (29%), Gaps = 102/380 (26%) Query: 124 KINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLR----G 179 K+ GE R R+ +A + + + + + P P P +R G Sbjct: 376 KVPGYGESIRERFERSLDLYLAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAG 435 Query: 180 HQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW 239 H+ + LS +P +L + SDD T+ +W+I + +R + +E + W Sbjct: 436 HKGKVRTLSIDP-SGLWLATGSDDGTVRVWEILTGREVYRT-TLIDDEENPDYHIECIEW 493 Query: 240 HLLHESLFGSVADDQKLMI-------WDTRNNNTSKPSHTV------------------- 273 + + +VA + + + +D NN +K Sbjct: 494 NPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENG 553 Query: 274 DAHTAEVN----------CLSFNPYSEF-----ILATGSADKTVA--LW----------- 305 D N +N S+ I T S KTV W Sbjct: 554 DGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQ 613 Query: 306 -DLRNLKLKLHSFESH---------KDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIG 355 D N + +H H K I ++ P + S R + ++DLS+ Sbjct: 614 PDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCS--QRYVRIYDLSQQI 671 Query: 356 EEQSTEDAEDGPPELLFIHGG-----------------------------HTAKISDFSW 386 + ++ G H + ++ Sbjct: 672 LVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNF 731 Query: 387 NPNEPWIICSVSEDNIMQVW 406 + P + S ++D + V+ Sbjct: 732 HKKLP-LFSSAADDGTIHVF 750 Score = 57.9 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 32/138 (23%), Positives = 54/138 (39%), Gaps = 18/138 (13%) Query: 130 EVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW 189 +++ P+ +IA+ + VL D + P LR H+K +++ Sbjct: 682 WLSKIDIHPRGDNLIAS-SFDKRVLWHDLDLAST---------PYKTLRYHEKAVRSVNF 731 Query: 190 NPNLNGYLLSASDDHTICLW--DINATPKEHRVIDAKNIFTGHTAV----VEDVAWHLLH 243 + L SA+DD TI ++ + ++ +I TGH + V D WH Sbjct: 732 HKKL-PLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPRE 790 Query: 244 ESLFGSVADDQKLMIWDT 261 LF S D +W T Sbjct: 791 AWLF-SAGADNTARLWTT 807 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 17/69 (24%), Positives = 29/69 (42%), Gaps = 1/69 (1%) Query: 356 EEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYND 415 E S +D P I+ GH K+ S +P+ W+ + S+D ++VW++ Sbjct: 415 ELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWL-ATGSDDGTVRVWEILTGREVY 473 Query: 416 EEPEIPASE 424 I E Sbjct: 474 RTTLIDDEE 482 >6EM1-m nrPDB Length = 807 Score = 79.8 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 42/234 (17%), Positives = 86/234 (36%), Gaps = 30/234 (12%) Query: 181 QKEGYGLSWNPNLNGYLLSA---SDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDV 237 +K LSW+ Y ++ S + ++ + ++ + +K ++ D Sbjct: 594 KKTVKKLSWHRK-GDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSK-------GIIMDA 645 Query: 238 AWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGS 297 +H LF + + I+D K + ++ + +P + ++A+ S Sbjct: 646 KFHPFKPQLFVC--SQRYVRIYDLSQQILVK---KLLPGARWLSKIDIHPRGDNLIAS-S 699 Query: 298 ADKTVALW-DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGE 356 DK V LW DL + H+ + V + + +S+ D +HV+ + + Sbjct: 700 FDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIHVFHATVYDD 757 Query: 357 EQSTEDAEDGPPELLFIHGGH----TAKISDFSWNPNEPWIICSVSEDNIMQVW 406 L GH + + D W+P E W+ S DN ++W Sbjct: 758 MMKNPMIV-----PLKKLTGHKVINSLGVLDAIWHPREAWLF-SAGADNTARLW 805 Score = 64.8 bits (156), Expect = 7e-11, Method: Composition-based stats. Identities = 68/441 (15%), Positives = 131/441 (29%), Gaps = 113/441 (25%) Query: 74 THTSDEQNHLLIASVQLPSEDAQFDGSH-----------YDNEKGEFGGFGSVCGKIEIE 122 T T+D HL + P+ + ++ ++N + + K Sbjct: 315 TETNDHVMHLRAPKLPPPTNEESYNPPEEYLLSPEEKEAWENTEYSERERNFIPQKYSAL 374 Query: 123 IKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLR---- 178 K+ GE R R+ +A + + + + + P P P +R Sbjct: 375 RKVPGYGESIRERFERSLDLYLAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYA 434 Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 GH+ + LS +P +L + SDD T+ +W+I + +R + +E + Sbjct: 435 GHKGKVRTLSIDP-SGLWLATGSDDGTVRVWEILTGREVYRT-TLIDDEENPDYHIECIE 492 Query: 239 WHLLHESLFGSVADDQKLMI-------WDTRNNNTSKPSHTV------------------ 273 W+ + +VA + + + +D NN +K Sbjct: 493 WNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNEN 552 Query: 274 -DAHTAEVN----------CLSFNPYSEF-----ILATGSADKTVA--LW---------- 305 D N +N S+ I T S KTV W Sbjct: 553 GDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTV 612 Query: 306 --DLRNLKLKLHSFESH---------KDEIFQVQWSPHNETILASSGTDRRLHVWDLSKI 354 D N + +H H K I ++ P + S R + ++DLS+ Sbjct: 613 QPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCS--QRYVRIYDLSQQ 670 Query: 355 GEEQSTEDAEDGPPELLFIHGG-----------------------------HTAKISDFS 385 + ++ G H + + Sbjct: 671 ILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVN 730 Query: 386 WNPNEPWIICSVSEDNIMQVW 406 ++ P + S ++D + V+ Sbjct: 731 FHKKLP-LFSSAADDGTIHVF 750 Score = 57.5 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 32/138 (23%), Positives = 54/138 (39%), Gaps = 18/138 (13%) Query: 130 EVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW 189 +++ P+ +IA+ + VL D + P LR H+K +++ Sbjct: 682 WLSKIDIHPRGDNLIAS-SFDKRVLWHDLDLAST---------PYKTLRYHEKAVRSVNF 731 Query: 190 NPNLNGYLLSASDDHTICLW--DINATPKEHRVIDAKNIFTGHTAV----VEDVAWHLLH 243 + L SA+DD TI ++ + ++ +I TGH + V D WH Sbjct: 732 HKKL-PLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPRE 790 Query: 244 ESLFGSVADDQKLMIWDT 261 LF S D +W T Sbjct: 791 AWLF-SAGADNTARLWTT 807 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 17/69 (24%), Positives = 29/69 (42%), Gaps = 1/69 (1%) Query: 356 EEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYND 415 E S +D P I+ GH K+ S +P+ W+ + S+D ++VW++ Sbjct: 415 ELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWL-ATGSDDGTVRVWEILTGREVY 473 Query: 416 EEPEIPASE 424 I E Sbjct: 474 RTTLIDDEE 482 >4E5Z-B nrPDB Length = 436 Score = 79.4 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 58/324 (17%), Positives = 99/324 (30%), Gaps = 67/324 (20%) Query: 132 NRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNP 191 + P + +A + D++++++ G G GL +NP Sbjct: 123 TSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGI--------GAGGSITGLKFNP 174 Query: 192 -NLNGYLLS-------------------ASDDHTICLW----DINATPKEHRVIDA---- 223 N N + S AS D TI +W D++A+ + D Sbjct: 175 LNTNQFYASSMEGTTRLQDFKGNILRVFASSD-TINIWFCSLDVSASSRMVVTGDNVGNV 233 Query: 224 ---------KNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVD 274 H V VA + + + + DQ + IWD R Sbjct: 234 ILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL 293 Query: 275 AHTAEVNCLSFNPYSEFILATGSADKT--VALWDLRNLKLKL------HSFESHKDEIFQ 326 H VN F+P +L T D+ + ++ L H H I Sbjct: 294 PHRHPVNAACFSPDGARLLTT---DQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA 350 Query: 327 VQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGP--PELLFIHGGHTAKISDF 384 W P I+ D S E T D DG + ++ ++ IS Sbjct: 351 -AWHPRYNLIVVGRYPDPNFK----SCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSL 405 Query: 385 S-WNPNEPWIICSVSEDNIMQVWQ 407 + +NP + ++ + +W Sbjct: 406 NEFNPMGDTLASAMGYH--ILIWS 427 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 33/184 (17%), Positives = 61/184 (33%), Gaps = 36/184 (19%) Query: 235 EDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILA 294 +AWH H S + +M+W+ + + + L FNP + Sbjct: 123 TSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGI-GAGGSITGLKFNPLNTNQFY 181 Query: 295 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW----D 350 S + T L D + L++ ASS +++W D Sbjct: 182 ASSMEGTTRLQDFKGNILRV----------------------FASSD---TINIWFCSLD 216 Query: 351 LSKIGEEQSTEDAEDGP------PELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQ 404 +S T D + L+ H K++ + NP W + + S D ++ Sbjct: 217 VSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVK 276 Query: 405 VWQM 408 +W + Sbjct: 277 IWDL 280 Score = 53.6 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 27/191 (14%), Positives = 62/191 (32%), Gaps = 25/191 (13%) Query: 127 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 186 H+ +V P +AT + V ++D + K H+ Sbjct: 249 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP-------HRHPVNA 301 Query: 187 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 246 ++P+ LL+ I ++ + +I + H ++ AWH + + Sbjct: 302 ACFSPD-GARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA-AWHPRYNLI 359 Query: 247 FGSVADD-----------QKLMIWDTRNNNTSKPSHTVDAHTAEVNCL-SFNPYSEFILA 294 D + + ++D N+ D ++ ++ L FNP + + + Sbjct: 360 VVGRYPDPNFKSCTPYELRTIDVFD--GNSGKMMCQLYDPESSGISSLNEFNPMGDTLAS 417 Query: 295 TGSADKTVALW 305 + +W Sbjct: 418 AMGY--HILIW 426 >3EI3-B nrPDB Length = 383 Score = 78.3 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 43/275 (15%), Positives = 87/275 (31%), Gaps = 53/275 (19%) Query: 182 KEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHL 241 + L W+P + S I LWD + K + G + + ++ Sbjct: 74 RRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGM-----GPGDAITGMKFNQ 128 Query: 242 LHESLFGSVA-------DDQKLMI---------WD-----TRNNNTSKPSHTVDA----- 275 + + + D + WD + + + T D+ Sbjct: 129 FNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQMLATGDSTGRLL 188 Query: 276 --------------HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES-- 319 H A+V FNP ++++AT S D TV LWDLRN+K K Sbjct: 189 LLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMP 248 Query: 320 HKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTA 379 H+ + ++P + T L ++ + V+ + + L Sbjct: 249 HEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKATWH 308 Query: 380 KISDFSWN---PNEPWIICSVSEDNIMQVWQMAEN 411 + D P++ ++ ++ + ++ Sbjct: 309 PMYDLIVAGRYPDDQLLL---NDKRTIDIYDANSG 340 Score = 71.7 bits (174), Expect = 5e-13, Method: Composition-based stats. Identities = 54/319 (16%), Positives = 92/319 (28%), Gaps = 57/319 (17%) Query: 131 VNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWN 190 V + P + +A + D++++DY G D G+ +N Sbjct: 76 VTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDA--------ITGMKFN 127 Query: 191 P-NLNGYLLSA----------------------SDDHTICLWDINATPKEHRVIDAKNIF 227 N N +S+ S D+ C D++ + + D+ Sbjct: 128 QFNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQMLATGDSTGRL 187 Query: 228 -------------TGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVD 274 H A V ++ + L + + D + +WD RN Sbjct: 188 LLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEM 247 Query: 275 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES------HKDEIFQVQ 328 H VN FNP L T + ++ + H I Sbjct: 248 PHEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKA-T 306 Query: 329 WSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNP 388 W P + I+A D +L L DA G IS ++P Sbjct: 307 WHPMYDLIVAGRYPDDQL----LLNDKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSP 362 Query: 389 NEPWIICSVSEDNIMQVWQ 407 ++ S NI+ +W Sbjct: 363 TG-DVLASGMGFNIL-IWN 379 Score = 62.5 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 35/195 (17%), Positives = 76/195 (38%), Gaps = 17/195 (8%) Query: 119 IEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLR 178 EI + H+ +V A + P+ ++AT + + V ++D K E Sbjct: 195 HEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMP------ 248 Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 H+K +NP + LL+ + I ++ K ++I + H ++ Sbjct: 249 -HEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKA-T 306 Query: 239 WHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAE-------VNCLSFNPYSEF 291 WH +++ + D +L++ D R + + H ++ F+P + Sbjct: 307 WHPMYDLIVAGRYPDDQLLLNDKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSPTGD- 365 Query: 292 ILATGSADKTVALWD 306 +LA+G + +W+ Sbjct: 366 VLASGMGFN-ILIWN 379 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 32/178 (17%), Positives = 54/178 (30%), Gaps = 30/178 (16%) Query: 261 TRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR-NLKLKLHSFES 319 R+ + K T V L ++P +A GS + LWD K Sbjct: 57 IRSLKSYKLHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMG 116 Query: 320 HKDEIFQVQWSPHNETILASSGTDR--RLH--------------VWDL------------ 351 D I ++++ N L S L WD Sbjct: 117 PGDAITGMKFNQFNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQ 176 Query: 352 -SKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 G+ +F H AK++ +NP W++ + S D +++W + Sbjct: 177 MLATGDSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDL 234 >3JZG-A nrPDB Length = 402 Score = 77.5 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 54/268 (20%), Positives = 94/268 (35%), Gaps = 56/268 (20%) Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 238 GH L ++P LLS S DH + LW+I ++ GH V Sbjct: 149 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTD----TLVAIFGGVEGHRDEVLSAD 204 Query: 239 WHLLHESLFGSVADDQKLMIW---------------DTRNNNTSKP----------SHTV 273 + LL E + S D L +W D N T++P T Sbjct: 205 YDLLGEKIM-SCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTR 263 Query: 274 DAHTAEVNCLSFNPYSEFILATGSADKTVALW-------DLRNLKLKLHS------FESH 320 D H V+C+ + ++ + S + + W D+ +K + F+ Sbjct: 264 DIHRNYVDCVRWLGD---LILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYS 320 Query: 321 KDEIFQVQWSPHN-ETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTA 379 + +I+ +++S + +LA +L+VWDL + H A Sbjct: 321 QCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHK--------AKCTTLTHHKCGA 372 Query: 380 KISDFSWNPNEPWIICSVSEDNIMQVWQ 407 I S++ + +I V +D + W Sbjct: 373 AIRQTSFSRDSSILIA-VCDDASIWRWD 399 Score = 77.1 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 36/255 (14%), Positives = 86/255 (33%), Gaps = 42/255 (16%) Query: 185 YGLSWNPNLNG---YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHL 241 Y +W + N L A I + + + GH + ++ +H Sbjct: 109 YTCAWTYDSNTSHPLLAVAGSRGIIRI-------INPITMQCIKHYVGHGNAINELKFHP 161 Query: 242 LHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKT 301 +L SV+ D L +W+ + + V+ H EV ++ E I+ + D + Sbjct: 162 RDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIM-SCGMDHS 220 Query: 302 VALWDLRNLKLK---------------------------LHSFESHKDEIFQVQWSPHNE 334 + LW + + ++ + + H++ + V+W + Sbjct: 221 LKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW--LGD 278 Query: 335 TILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNE-PWI 393 IL+ S + + W K+ ++ + +L I ++ + + Sbjct: 279 LILSKSCENAIVC-WKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKM 337 Query: 394 ICSVSEDNIMQVWQM 408 + ++ + VW + Sbjct: 338 LALGNQVGKLYVWDL 352 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 27/167 (16%), Positives = 66/167 (39%), Gaps = 28/167 (16%) Query: 276 HTAEVNCLSFNPYS----EFILATGSADKTVALWDLRNLKLKLHSFESHKDE-----IFQ 326 H + + FN +S + AT + V L++ + ++ +S+ D + Sbjct: 53 HNQPLFGVQFNWHSKEGDPLVFATVGS-NRVTLYECHSQG-EIRLLQSYVDADADENFYT 110 Query: 327 VQW---SPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISD 383 W S + +LA +G+ + + + + + + GH I++ Sbjct: 111 CAWTYDSNTSHPLLAVAGSRGIIRIINP--------------ITMQCIKHYVGHGNAINE 156 Query: 384 FSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETNTA 430 ++P +P ++ SVS+D+ +++W + + + E +A Sbjct: 157 LKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSA 203 >5M89-A nrPDB Length = 329 Score = 76.0 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 54/299 (18%), Positives = 107/299 (35%), Gaps = 25/299 (8%) Query: 51 AQWLPDVTKQDGKDYSVHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFG 110 + + +V +Q K + G T+D+ L Q+ D + + + E Sbjct: 11 VEHVNEVQQQLMKTRKKRPIPQGWATADDVAALQ----QVAYTDLNVTQASSLDLENECA 66 Query: 111 GFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGE 170 G + GK++I + ++ E R + V AT + +V K K +G Sbjct: 67 AVGGLDGKLDIYSVVANKVE----RTLDIGEPVTAT-EWTGTKVVIGTAKGWVKVYDAGR 121 Query: 171 CQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGH 230 + H GL+ +P L S D + +D+ + R Sbjct: 122 --ESATFQTHAGPVTGLAVHP-GGRILASVGVDKSFVFYDLETGERVARGYA-------- 170 Query: 231 TAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSE 290 A + A+H +LF + ++++ T T + + + T + L+F+ Sbjct: 171 DAALTTCAFHPDG-NLFAAGTQTGHILVFHT---TTLEQAESFPLGT-PIQALAFSENGF 225 Query: 291 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 + ATG +V ++DLR E E+ + W + + GT + ++ Sbjct: 226 WFAATGKGTSSVTIFDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATGGGTGVTVQMY 284 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 30/212 (14%), Positives = 68/212 (32%), Gaps = 26/212 (12%) Query: 204 HTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRN 263 T W K + F H V +A H + SV D+ + +D Sbjct: 108 GTAKGW-----VKVYDAGRESATFQTHAGPVTGLAVHPGGR-ILASVGVDKSFVFYDLET 161 Query: 264 NNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE 323 + A + +F+P + A G+ + ++ L+ Sbjct: 162 GERVARGYA----DAALTTCAFHPDG-NLFAAGTQTGHILVFHTTTLEQAESFPLG--TP 214 Query: 324 IFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISD 383 I + +S + A+ + ++DL K G + ++ + T ++ Sbjct: 215 IQALAFSENGFWFAATGKGTSSVTIFDLRKSGAAAAVKELQ-------------TGEVLS 261 Query: 384 FSWNPNEPWIICSVSEDNIMQVWQMAENVYND 415 SW+ ++ +Q++ A +++ Sbjct: 262 ISWDYTGQYLATGGGTGVTVQMYTKATKSWSE 293 >5MWJ-A nrPDB Length = 337 Score = 75.2 bits (183), Expect = 5e-14, Method: Composition-based stats. Identities = 37/216 (17%), Positives = 64/216 (29%), Gaps = 23/216 (10%) Query: 210 DINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKP 269 D P R N H VV V ++ + +WD + P Sbjct: 31 DALIGPGIPRHARQINTL-NHGEVVCAVTISNPTRHVYTGGK--GCVKVWDISHPGNKSP 87 Query: 270 SHTVD--AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQ 326 +D + P L G T+++WDL ++ S + Sbjct: 88 VSQLDCLNRDNYIRSCKLLPDG-CTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYA 146 Query: 327 VQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSW 386 + SP + + S +D + VWDL L+ GHT S Sbjct: 147 LAISP-DSKVCFSCCSDGNIAVWDLHNQT--------------LVRQFQGHTDGASCIDI 191 Query: 387 NPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPA 422 + + + + DN ++ W + E + Sbjct: 192 SNDGTKL-WTGGLDNTVRSWDLREGRQLQQHDFTSQ 226 Score = 64.8 bits (156), Expect = 6e-11, Method: Composition-based stats. Identities = 31/215 (14%), Positives = 71/215 (33%), Gaps = 28/215 (13%) Query: 137 MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGY 196 + ++ V + ++ V+D + +GH + + N Sbjct: 149 ISPDSKVCFSCCSDGNIAVWDLH----------NQTLVRQFQGHTDGASCIDIS-NDGTK 197 Query: 197 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 256 L + D+T+ WD+ + + IF + + E + + Sbjct: 198 LWTGGLDNTVRSWDLREGRQLQQHDFTSQIF--------SLGYCPTGE-WLAVGMESSNV 248 Query: 257 MIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 316 + + + + H + V L F ++ ++TG D + W S Sbjct: 249 EVLHVNKPDKYQ----LHLHESCVLSLKFAYCGKWFVSTG-KDNLLNAWRTPYGASIFQS 303 Query: 317 FESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 351 ES + S ++ I+ SG D++ V+++ Sbjct: 304 KES--SSVLSCDISVDDKYIVTGSG-DKKATVYEV 335 >6E29-D nrPDB Length = 345 Score = 74.1 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 47/303 (15%), Positives = 98/303 (32%), Gaps = 50/303 (16%) Query: 128 EGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGL 187 G R+ + +A+ V+++D +LRGH K L Sbjct: 25 SGHSTCVRFN-RKGDFLASGRVDGTVVIWDLETMGVA----------RKLRGHSKNITSL 73 Query: 188 SWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLF 247 SW+ YLLSA + LWD+ + V A V H + F Sbjct: 74 SWSRC-GRYLLSACQGWKVILWDLQDGKRYREVRF--------RAPVYGAELHPWNHHQF 124 Query: 248 GSVADDQKLMIWDT---------------RNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI 292 + + + M+ D R + + P+ + ++ I Sbjct: 125 AAALFEDQPMLVDITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTA-----I 179 Query: 293 LATGSADKTVA--------LWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDR 344 + T S D +A + D R ++ + I ++ + +L ++ DR Sbjct: 180 VYTASGDHLLAGTTKGRLNIIDARTREIIYSEKIA-SGIITTLRLTESGRELLVNA-QDR 237 Query: 345 RLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQ 404 + + + + D P E F + + +++ ++ S ++ + Sbjct: 238 IIRTFIVPNLSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELY 297 Query: 405 VWQ 407 +W+ Sbjct: 298 IWE 300 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 17/91 (18%), Positives = 35/91 (38%), Gaps = 19/91 (20%) Query: 318 ESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGH 377 H V+++ + LAS D + +WDL +G + GH Sbjct: 25 SGHS---TCVRFNRKGD-FLASGRVDGTVVIWDLETMGVARKLR--------------GH 66 Query: 378 TAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 + I+ SW+ +++ S + + +W + Sbjct: 67 SKNITSLSWSRCGRYLL-SACQGWKVILWDL 96 Score = 44.4 bits (103), Expect = 9e-05, Method: Composition-based stats. Identities = 40/250 (16%), Positives = 88/250 (35%), Gaps = 31/250 (12%) Query: 125 INHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKH-------PSKPEPSG-ECQPDLR 176 + V A P N A ++ D T+ PS P+ + E P LR Sbjct: 105 VRFRAPVYGAELHPWNHHQFAAALFEDQPMLVDITEPVEVRYVLPSVPKRTSTETDPALR 164 Query: 177 LRGHQKE---GYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAV 233 + +++ +LL+ + + + D +I ++ I +G + Sbjct: 165 EKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNIIDART----REIIYSEKIASG---I 217 Query: 234 VEDVAWHLLHESLFGSVADDQKLMIWDTRNNNT----SKPSHTVDAHT-AEV------NC 282 + + L + D+ + + N + H +V N Sbjct: 218 ITTLRLTESGRELLVNA-QDRIIRTFIVPNLSAADLDPDTIQLPLEHKFQDVVNRLSWNH 276 Query: 283 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGT 342 ++F+ E++ A+ + + +W+ R + E K+E ++W PH + A Sbjct: 277 VAFSATGEYVAASTYNNHELYIWE-RGHGSLVRMLEGPKEEQGVIEWHPHRALLAACGLE 335 Query: 343 DRRLHVWDLS 352 R+++W ++ Sbjct: 336 TGRINIWSVT 345 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 52/343 (15%), Positives = 106/343 (30%), Gaps = 68/343 (19%) Query: 104 NEKGEFGGFGSVCGKIEI---------EIKINHEGEVNRARYMPQNACVIATKTPSSDVL 154 N KG+F G V G + I H + + +++ V+ Sbjct: 34 NRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRYLLSACQG-WKVI 92 Query: 155 VFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINAT 214 ++D G+ ++R R YG +P + +A + L DI Sbjct: 93 LWDLQD--------GKRYREVRFRA---PVYGAELHPWNHHQFAAALFEDQPMLVDITEP 141 Query: 215 PKEHRVIDAKNIFTGHT---------------AVVEDVAWHLLHESLFGSVADDQKLMIW 259 + V+ + T + + + + L +L I Sbjct: 142 VEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLA-GTTKGRLNII 200 Query: 260 DTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW--------DLRNLK 311 D R T + ++ + + L +L D+ + + DL Sbjct: 201 DAR---TREIIYSEKIASGIITTLRLTESGRELLVNA-QDRIIRTFIVPNLSAADLDPDT 256 Query: 312 LKL---HSFESHKDEI--FQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 366 ++L H F+ + + V +S E + AS+ + L++W E G Sbjct: 257 IQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIW--------------ERG 302 Query: 367 PPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMA 409 L+ + G + W+P+ + E + +W + Sbjct: 303 HGSLVRMLEGPKEEQGVIEWHPHRALLAACGLETGRINIWSVT 345 >5CXB-B nrPDB Length = 369 Score = 73.3 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 41/240 (17%), Positives = 79/240 (32%), Gaps = 41/240 (17%) Query: 181 QKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVV------ 234 + +SW+ + + S P R A + + H + Sbjct: 156 RSTIKAISWHR-RGDHFATVS-------------PSGQRSSVAIHTLSKHLTQIPFRKLN 201 Query: 235 ---EDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEF 291 + ++H L F VA + + +D + V ++ +P + Sbjct: 202 GLAQTASFHPLRPLFF--VATQRSIRCYDL---QKLELVKIVQPGAKWISSFDVHPGGDN 256 Query: 292 ILATGSADKTVALW-DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWD 350 ++ GS DK + LW DL + H + I V++ + A + D L + Sbjct: 257 LVV-GSYDKRL-LWHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQI-- 312 Query: 351 LSKIGEEQSTEDAEDGPPELLFIHGGHTA----KISDFSWNPNEPWIICSVSEDNIMQVW 406 + + E+ + + GH + D W+P EPW S D ++W Sbjct: 313 ---FHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPW-CVSAGADGTARLW 368 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 20/79 (25%), Positives = 35/79 (44%), Gaps = 3/79 (3%) Query: 272 TVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP 331 H V ++ +P LATG D TV +W+L + + + + V+W P Sbjct: 16 IFRGHEGRVRSVAIDPTGV-ALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRP 74 Query: 332 HNETIL--ASSGTDRRLHV 348 +T + A++G D L + Sbjct: 75 TKDTFILAAAAGEDIFLMI 93 Score = 55.9 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 19/93 (20%), Positives = 33/93 (35%), Gaps = 7/93 (7%) Query: 173 PDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLW--DINATPKEHRVIDAKNIFTGH 230 P +R H + + ++ ASDD ++ ++ + E+ I + GH Sbjct: 277 PYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGH 336 Query: 231 TAV----VEDVAWHLLHESLFGSVADDQKLMIW 259 V V D+ WH S D +W Sbjct: 337 KVVNKLGVLDIDWHPREP-WCVSAGADGTARLW 368 Score = 51.3 bits (121), Expect = 8e-07, Method: Composition-based stats. Identities = 20/100 (20%), Positives = 36/100 (36%), Gaps = 10/100 (10%) Query: 161 HPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRV 220 P + +P Q RGH+ ++ +P L + DD T+ +W++ + V Sbjct: 2 SPDELKPFPTVQ-QTIFRGHEGRVRSVAIDP-TGVALATGGDDGTVRVWELLTGRQVWSV 59 Query: 221 IDAKNIFTGHTAVVEDVAWHLLHESLF--GSVADDQKLMI 258 V V W ++ + +D LMI Sbjct: 60 KLNG------DEAVNTVRWRPTKDTFILAAAAGEDIFLMI 93 Score = 51.3 bits (121), Expect = 9e-07, Method: Composition-based stats. Identities = 16/95 (16%), Positives = 32/95 (33%), Gaps = 14/95 (14%) Query: 311 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPEL 370 ++ F H+ + V P LA+ G D + VW+L + S + D Sbjct: 11 TVQQTIFRGHEGRVRSVAIDPTGVA-LATGGDDGTVRVWELLTGRQVWSVKLNGDEA--- 66 Query: 371 LFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQV 405 ++ W P + I + + + + Sbjct: 67 ----------VNTVRWRPTKDTFILAAAAGEDIFL 91 Score = 48.2 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 16/79 (20%), Positives = 27/79 (34%), Gaps = 5/79 (6%) Query: 223 AKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNC 282 + IF GH V VA +L + DD + +W+ + VN Sbjct: 13 QQTIFRGHEGRVRSVAIDPTGVAL-ATGGDDGTVRVWELLTG--RQVWSVKLNGDEAVNT 69 Query: 283 LSFNPYSEFIL--ATGSAD 299 + + P + + A D Sbjct: 70 VRWRPTKDTFILAAAAGED 88 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 9/53 (16%), Positives = 23/53 (43%), Gaps = 1/53 (1%) Query: 359 STEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 S ++ + P I GH ++ + +P + + +D ++VW++ Sbjct: 2 SPDELKPFPTVQQTIFRGHEGRVRSVAIDPTG-VALATGGDDGTVRVWELLTG 53 >3DW8-B nrPDB Length = 447 Score = 72.9 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 52/334 (15%), Positives = 112/334 (33%), Gaps = 67/334 (20%) Query: 100 SHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQ-NACVIATKTPSSDVLVFDY 158 SH E + F S + + + E ++N+ R++PQ NA T + ++ Sbjct: 65 SHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKI 124 Query: 159 TKHPSKPEPSGECQPDLRLR------------------------------GHQKEGYGLS 188 ++ +PE + D R R H +S Sbjct: 125 SERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSIS 184 Query: 189 WNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNI-FTGHTAVVEDVAWHLLHESLF 247 N + YL ++DD I LW + T + ++D K T V+ +H + F Sbjct: 185 INSDYETYL--SADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTF 242 Query: 248 GSVADDQKLMIWDTRNNN-TSKPSHTVDAHTAE------------VNCLSFNPYSEFILA 294 + + + D R + + S + ++ + F+ +++ Sbjct: 243 VYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMM- 301 Query: 295 TGSAD-KTVALWDLRNLKLKLHSFESH------------KDEIFQ---VQWSPHNETILA 338 + D +V +WDL + +++ H D IF W+ + +++ Sbjct: 302 --TRDYLSVKVWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSD-SVVM 358 Query: 339 SSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLF 372 + + ++D + + E+ P + Sbjct: 359 TGSYNNFFRMFDRNTKRDITLEASRENNKPRTVL 392 Score = 35.1 bits (79), Expect = 0.061, Method: Composition-based stats. Identities = 24/141 (17%), Positives = 48/141 (34%), Gaps = 14/141 (9%) Query: 294 ATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSK 353 A G D W +K + + D I V+++ E +LA+ R+ ++ + Sbjct: 4 AGGGNDIQ---WCFSQVKGAVDDDVAEADIISTVEFNHSGE-LLATGDKGGRVVIFQQEQ 59 Query: 354 IGEEQSTEDAEDGPPELLFIHGGH---------TAKISDFSWNPNE-PWIICSVSEDNIM 403 + QS E H KI+ W P + + D + Sbjct: 60 ENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTI 119 Query: 404 QVWQMAENVYNDEEPEIPASE 424 ++W+++E E + + Sbjct: 120 KLWKISERDKRPEGYNLKEED 140 >6BX3-B nrPDB Length = 412 Score = 71.7 bits (174), Expect = 6e-13, Method: Composition-based stats. Identities = 27/106 (25%), Positives = 48/106 (45%), Gaps = 6/106 (5%) Query: 268 KPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL---RNLKLKLHSFESHKDEI 324 K +HT++ CL F+P ++ LA G A+ + ++D+ R + + + +H I Sbjct: 17 KLTHTIEN-PLRTECLQFSPCGDY-LALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI 74 Query: 325 FQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPEL 370 + WSP +L SS D + +WDLSK + + Sbjct: 75 TSIAWSPDGRLLLTSS-RDWSIKLWDLSKPSKPLKEIRFDSPIWGC 119 Score = 61.3 bits (147), Expect = 8e-10, Method: Composition-based stats. Identities = 50/297 (16%), Positives = 101/297 (34%), Gaps = 75/297 (25%) Query: 171 CQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKE------------- 217 C P L H + ++W+P+ LL++S D +I LWD++ K Sbjct: 61 CVPGNMLGAHVRPITSIAWSPD-GRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGC 119 Query: 218 -----HRVIDAKNIFTGHTAVVED-----------------------------VAWHLLH 243 R + IF A V D H H Sbjct: 120 QWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKH 179 Query: 244 ESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVA 303 ++ L + + ++ H++ ++ + L + E + S D+T+ Sbjct: 180 PNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCS-DRTIR 238 Query: 304 LW----DLRNLKLKLHSFESHKDEIFQVQW------SPHNETILAS--SGTDRRLHVWDL 351 + D N ++L ++D I ++QW + E ++AS + L++W+ Sbjct: 239 QYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWET 298 Query: 352 SKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 + L+ + G ++ D +W+ I+ + E + VW + Sbjct: 299 TSGT--------------LVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 341 Score = 34.0 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 31/245 (12%), Positives = 80/245 (32%), Gaps = 41/245 (16%) Query: 123 IKINHEGEVNRARYM-PQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQ 181 +I + + +++ + +AT SD V D++ P S + L Sbjct: 108 KEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDH 167 Query: 182 KEGYGLSWNPNLNGYLLSASDDHTICLW-DINATPKEHRVIDAKNIFTGHTAVVEDVAWH 240 + + ++ T W D ++ + + ++ ++ + Sbjct: 168 GYVLVCTVHTKHPNIII----VGTSKGWLDFYKFHSLYQT-ECIHSLKITSSNIKHLIVS 222 Query: 241 LLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHT--AEVNCLSFNP------YSEFI 292 E L + + D+ + ++ ++ + H +N L +N +E++ Sbjct: 223 QNGERLAINCS-DRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYL 281 Query: 293 LAT--GSADKTVALW-----------------------DLRNLKLKLHSFESHKDEIFQV 327 +A+ GS+ + +W D ++ + + FES ++ V Sbjct: 282 VASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 341 Query: 328 QWSPH 332 P Sbjct: 342 VIPPK 346 >5K19-A nrPDB Length = 569 Score = 71.7 bits (174), Expect = 6e-13, Method: Composition-based stats. Identities = 39/272 (14%), Positives = 94/272 (34%), Gaps = 49/272 (18%) Query: 181 QKEGYGLSWNPNLNGYLLSASDDHTICLWDIN----ATPKEHRVIDAKNIFTGHT----- 231 + + W P L A + L+++ T ++++ F HT Sbjct: 149 KSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKS 208 Query: 232 ------------AVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAE 279 + + A+ + V+ D L +++ ++ + T+ ++ Sbjct: 209 TRNPLLKWTVGEGALNEFAFSPDGK-FLACVSQDGFLRVFNF---DSVELHGTMKSYFGG 264 Query: 280 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETI--- 336 + C+ ++P ++I+ TG D V +W + ++ + HK + V + P+ ++ Sbjct: 265 LLCVCWSPDGKYIV-TGGEDDLVTVWSFVDCRV-IARGHGHKSWVSVVAFDPYTTSVEEG 322 Query: 337 ----LASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 392 + S D + DL G +++ S + + Sbjct: 323 DPMEFSGSDEDFQ----DLLHFGRDRANSTQSRLSKRNSTD-----------SRPVSVTY 367 Query: 393 IICSVSEDNIMQVWQMAENVYNDEEPEIPASE 424 SV +D + +W + E++ +P A Sbjct: 368 RFGSVGQDTQLCLWDLTEDILFPHQPLSRART 399 Score = 44.8 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 27/153 (17%), Positives = 49/153 (32%), Gaps = 18/153 (11%) Query: 148 TPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNP------NLNGYLLSAS 201 +P +V +C+ R GH+ ++++P + S S Sbjct: 271 SPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGS 330 Query: 202 D-DHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWD 260 D D D+ ++ + ++ V+ FGSV D +L +WD Sbjct: 331 DEDFQ----DLLHFGRDRANSTQSRLSKRNSTDSRPVSV----TYRFGSVGQDTQLCLWD 382 Query: 261 TRNNNT--SKPSHTVDAHTAEVNCLSFNPYSEF 291 + +P HT +N S P Sbjct: 383 LTEDILFPHQPLSRARTHTNVMNATS-PPAGSN 414 >2P9P-C nrPDB Length = 372 Score = 70.6 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 35/245 (14%), Positives = 82/245 (33%), Gaps = 23/245 (9%) Query: 183 EGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLL 242 +WN + + ++H + +++ K + H V V W Sbjct: 10 PISCHAWNKDRTQIAI-CPNNHEVHIYE-----KSGNKWVQVHELKEHNGQVTGVDWAP- 62 Query: 243 HESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPY-SEFILATGSADKT 301 + + D+ +W + T KP+ + C+ + P +F + +GS + Sbjct: 63 DSNRIVTCGTDRNAYVWTLK-GRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVIS 121 Query: 302 VALWDLRNLK-LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLS----KIGE 356 + ++ N + H + + + + W P N +LA+ D + ++ + Sbjct: 122 ICYFEQENDWWVCKHIKKPIRSTVLSLDWHP-NSVLLAAGSCDFKCRIFSAYIKEVEERP 180 Query: 357 EQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWI--------ICSVSEDNIMQVWQM 408 + ++ EL+F + ++ N + +C D M V + Sbjct: 181 APTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAVATL 240 Query: 409 AENVY 413 A Sbjct: 241 ASETL 245 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 42/280 (15%), Positives = 83/280 (29%), Gaps = 43/280 (15%) Query: 127 HEGEVNRARYMPQNAC--VIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEG 184 H V N IA + +V +++ + + L+ H + Sbjct: 4 HSFLVEPISCHAWNKDRTQIAICPNNHEVHIYE--------KSGNKWVQVHELKEHNGQV 55 Query: 185 YGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHE 244 G+ W P+ N +++ D +W + R + V W +E Sbjct: 56 TGVDWAPDSNR-IVTCGTDRNAYVWTLKG-----RTWKPTLVILRINRAARCVRWAP-NE 108 Query: 245 SLFGSVADDQKLMI-WDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVA 303 F + + + I + + N+ H + V L ++P + +LA GS D Sbjct: 109 KKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHP-NSVLLAAGSCDFKCR 167 Query: 304 LWD----------LRNLKLKLHSF-------ESHKDEIFQVQWSPHNETILASSGTDRRL 346 ++ F S + V +S + + A D + Sbjct: 168 IFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRV-AWVSHDSTV 226 Query: 347 HVWD------LSKIGEEQSTEDAEDGPPELLFIHGGHTAK 380 + D ++ + E A E + GH Sbjct: 227 CLADADKKMAVATLASETLPLLAVTFITESSLVAAGHDCF 266 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 50/336 (14%), Positives = 99/336 (29%), Gaps = 61/336 (18%) Query: 119 IEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLR 178 +++ H G+V + P ++ I T + V+ KP LR+ Sbjct: 43 VQVHELKEHNGQVTGVDWAP-DSNRIVTCGTDRNAYVWTLKGRTWKPTLV-----ILRIN 96 Query: 179 GHQKEGYGLSWNPNLNGYLL-SASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDV 237 + + W PN + + S S +IC ++ + I + V + Sbjct: 97 ---RAARCVRWAPNEKKFAVGSGSRVISICYFEQENDWWVCKHIKKPI-----RSTVLSL 148 Query: 238 AWHLLHESLFGSVADDQKLMIW-----DTRNNNTSKP----------SHTVDAHTAEVNC 282 WH + L + + D K I+ + P + V+ Sbjct: 149 DWHP-NSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHG 207 Query: 283 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGT 342 + F+ + +A S D TV L D + K+ + + S + V + + + A Sbjct: 208 VCFS-ANGSRVAWVSHDSTVCLADA-DKKMAVATLASETLPLLAVTFITESSLVAAGHDC 265 Query: 343 DRRLHVWD-------------------LSKIGEEQSTEDAEDGPPELLFIHGG------H 377 L +D + + ++ + G H Sbjct: 266 FPVLFTYDSAAGKLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGSAAAGAGLDSLH 325 Query: 378 TAKISDFSWNPNEPWII---CSVSEDNIMQVWQMAE 410 +S S C+ D M +W + Sbjct: 326 KNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVRS 361 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 26/172 (15%), Positives = 59/172 (34%), Gaps = 38/172 (22%) Query: 279 EVNCLSFNPYSEFILATGSADKTVALWDLR-NLKLKLHSFESHKDEIFQVQWSPHNETIL 337 ++C ++N I A + V +++ N +++H + H ++ V W+P + I+ Sbjct: 10 PISCHAWNKDRTQI-AICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIV 68 Query: 338 ASSGTDRRLHVWDLSKIGEEQST----------------------------------EDA 363 + GTDR +VW L + + + Sbjct: 69 -TCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQ 127 Query: 364 EDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYND 415 E+ I + + W+PN ++ + S D +++ + Sbjct: 128 ENDWWVCKHIKKPIRSTVLSLDWHPN-SVLLAAGSCDFKCRIFSAYIKEVEE 178 >4J0X-A nrPDB Length = 451 Score = 69.0 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 63/353 (17%), Positives = 111/353 (31%), Gaps = 57/353 (16%) Query: 82 HLLIASVQLPSED-AQFDGSHYDNEKGEFGGFGSVCGKIEIE-IKINHEGEVNRARYMPQ 139 + + +QL D F + + G K E E H E+ P Sbjct: 66 YTVSKDLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSKHEYENTTEGHYDEILTVAASPD 125 Query: 140 NACVIATKTPSSDVLVFDY-TKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLL 198 V+ T ++V+ + P K P+ + + E L++ N + Sbjct: 126 GKYVV-TGGRDRKLIVWSTESLSPVKVIPTKDR---------RGEVLSLAFRKNSDQLYA 175 Query: 199 SASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMI 258 S + D I + IN I GH +VED++ L E A D+ M+ Sbjct: 176 SCA-DFKIRTYSINQ-------FSQLEILYGHHDIVEDIS-ALAMERCVTVGARDRTAML 226 Query: 259 WDTRNNNTSKPSHTVDAHTAEVNCLS-FNPYSEFILATGSADKTVALWDLRNLKLKLHSF 317 W + + T L + + A D V D + L Sbjct: 227 WKIPD----ETRLTFRGGDEPQKLLRRWMKEN----AKEGEDGEVKYPD--ESEAPLFFC 276 Query: 318 ESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIH-GG 376 E D + V ++ + + + +W L+K + A PE F G Sbjct: 277 EGSIDVVSMV-----DDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISG 331 Query: 377 HTAK-----------------ISDFSWNPNEPWIICSVSEDNIMQVWQMAENV 412 T + I+ P + S S ++VW++++N+ Sbjct: 332 ETDEELRKRQLQGKKLLQPFWITSLYAIPY-SNVFISGSWSGSLKVWKISDNL 383 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 42/264 (15%), Positives = 82/264 (31%), Gaps = 59/264 (22%) Query: 120 EIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKP-----EPSGECQPD 174 ++EI H V + CV +++ EP + Sbjct: 192 QLEILYGHHDIVEDISALAMERCV-TVGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRW 250 Query: 175 LRLRGHQKEGYGLSWNPNLNG-------------------YLLSASDDHTICLWDINATP 215 ++ + E + + P+ + + ++ SD+ ICLW + Sbjct: 251 MKENAKEGEDGEVKY-PDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSL--AK 307 Query: 216 KEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDA 275 K+ + D+ S D++L + +P Sbjct: 308 KKPIFTERIAHGILPEPSFNDI-----------SGETDEELRKRQLQGKKLLQPF----- 351 Query: 276 HTAEVNCLSFNPYSEFILATGSADKTVALW----DLRNLKLKLHSFESHKDEIFQVQWSP 331 + L PYS + +GS ++ +W +LR+ +L L K + ++Q Sbjct: 352 ---WITSLYAIPYS-NVFISGSWSGSLKVWKISDNLRSFEL-LGELSGAKGVVTKIQVVE 406 Query: 332 HNE------TILASSGTDRRLHVW 349 + ILAS + RL W Sbjct: 407 SGKHGKEKFRILASIAKEHRLGRW 430 Score = 37.5 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 11/84 (13%), Positives = 28/84 (33%), Gaps = 9/84 (10%) Query: 332 HNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIH--------GGHTAKISD 383 + D +L +D++ + G + + GH +I Sbjct: 60 KGRLFAYTVSKDLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSKHEYENTTEGHYDEILT 119 Query: 384 FSWNPNEPWIICSVSEDNIMQVWQ 407 + +P+ +++ + D + VW Sbjct: 120 VAASPDGKYVV-TGGRDRKLIVWS 142 >5WLC-SG nrPDB Length = 573 Score = 68.3 bits (165), Expect = 7e-12, Method: Composition-based stats. Identities = 63/353 (17%), Positives = 111/353 (31%), Gaps = 57/353 (16%) Query: 82 HLLIASVQLPSED-AQFDGSHYDNEKGEFGGFGSVCGKIEIE-IKINHEGEVNRARYMPQ 139 + + +QL D F + + G K E E H E+ P Sbjct: 188 YTVSKDLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSKHEYENTTEGHYDEILTVAASPD 247 Query: 140 NACVIATKTPSSDVLVFDY-TKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLL 198 V+ T ++V+ + P K P+ + + E L++ N + Sbjct: 248 GKYVV-TGGRDRKLIVWSTESLSPVKVIPTKDR---------RGEVLSLAFRKNSDQLYA 297 Query: 199 SASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMI 258 S + D I + IN I GH +VED++ L E A D+ M+ Sbjct: 298 SCA-DFKIRTYSINQ-------FSQLEILYGHHDIVEDIS-ALAMERCVTVGARDRTAML 348 Query: 259 WDTRNNNTSKPSHTVDAHTAEVNCLS-FNPYSEFILATGSADKTVALWDLRNLKLKLHSF 317 W + + T L + + A D V D + L Sbjct: 349 WKIPD----ETRLTFRGGDEPQKLLRRWMKEN----AKEGEDGEVKYPD--ESEAPLFFC 398 Query: 318 ESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIH-GG 376 E D + V ++ + + + +W L+K + A PE F G Sbjct: 399 EGSIDVVSMV-----DDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISG 453 Query: 377 HTAK-----------------ISDFSWNPNEPWIICSVSEDNIMQVWQMAENV 412 T + I+ P + S S ++VW++++N+ Sbjct: 454 ETDEELRKRQLQGKKLLQPFWITSLYAIPY-SNVFISGSWSGSLKVWKISDNL 505 Score = 45.5 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 42/264 (15%), Positives = 82/264 (31%), Gaps = 59/264 (22%) Query: 120 EIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKP-----EPSGECQPD 174 ++EI H V + CV +++ EP + Sbjct: 314 QLEILYGHHDIVEDISALAMERCV-TVGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRW 372 Query: 175 LRLRGHQKEGYGLSWNPNLNG-------------------YLLSASDDHTICLWDINATP 215 ++ + E + + P+ + + ++ SD+ ICLW + Sbjct: 373 MKENAKEGEDGEVKY-PDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSL--AK 429 Query: 216 KEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDA 275 K+ + D+ S D++L + +P Sbjct: 430 KKPIFTERIAHGILPEPSFNDI-----------SGETDEELRKRQLQGKKLLQPF----- 473 Query: 276 HTAEVNCLSFNPYSEFILATGSADKTVALW----DLRNLKLKLHSFESHKDEIFQVQWSP 331 + L PYS + +GS ++ +W +LR+ +L L K + ++Q Sbjct: 474 ---WITSLYAIPYS-NVFISGSWSGSLKVWKISDNLRSFEL-LGELSGAKGVVTKIQVVE 528 Query: 332 HNE------TILASSGTDRRLHVW 349 + ILAS + RL W Sbjct: 529 SGKHGKEKFRILASIAKEHRLGRW 552 Score = 37.1 bits (84), Expect = 0.017, Method: Composition-based stats. Identities = 11/84 (13%), Positives = 28/84 (33%), Gaps = 9/84 (10%) Query: 332 HNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIH--------GGHTAKISD 383 + D +L +D++ + G + + GH +I Sbjct: 182 KGRLFAYTVSKDLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSKHEYENTTEGHYDEILT 241 Query: 384 FSWNPNEPWIICSVSEDNIMQVWQ 407 + +P+ +++ + D + VW Sbjct: 242 VAASPDGKYVV-TGGRDRKLIVWS 264 >5OV3-A nrPDB Length = 381 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 34/271 (12%), Positives = 92/271 (33%), Gaps = 30/271 (11%) Query: 141 ACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSA 200 ++A ++++D+ + H L W+ + L+SA Sbjct: 37 GTLLAVGCNDGRIVIWDFLTRGIAK----------IISAHIHPVCSLCWSRD-GHKLVSA 85 Query: 201 SDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWD 260 S D+ + WD+ + + R I V +H ++ + + Sbjct: 86 STDNIVSQWDVLSGDCDQRFRFPSPILK--------VQYHPRDQNKVLVCPM-KSAPV-- 134 Query: 261 TRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL----KLKLHS 316 + SK +++N ++ + TG+A + + + ++ + Sbjct: 135 MLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTT 194 Query: 317 FESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGG 376 S+ I ++++ L ++ DR + V+D +I + E ++ Sbjct: 195 GTSNTTAIKSIEFARKGSCFLINTA-DRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRT 253 Query: 377 HTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 407 K ++ + +I+ + + + +W+ Sbjct: 254 PWKKC---CFSGDGEYIVAGSARQHALYIWE 281 Score = 48.2 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 17/82 (20%), Positives = 29/82 (35%), Gaps = 15/82 (18%) Query: 334 ETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWI 393 T+LA D R+ +WD G + I H + W+ + + Sbjct: 37 GTLLAVGCNDGRIVIWDFLTRG--------------IAKIISAHIHPVCSLCWSRDGHKL 82 Query: 394 ICSVSEDNIMQVWQMAENVYND 415 + S S DNI+ W + + Sbjct: 83 V-SASTDNIVSQWDVLSGDCDQ 103 Score = 44.8 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 29/240 (12%), Positives = 80/240 (33%), Gaps = 27/240 (11%) Query: 120 EIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRG 179 + + + + + +Y P++ + S ++ + P + Sbjct: 100 DCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDD--------- 150 Query: 180 HQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW 239 + ++ Y+ + + I + + ++ T +T ++ + + Sbjct: 151 -DSDLNVVASFDRRGEYIYTGNAKGKILV--LKTDSQDLVASFRVTTGTSNTTAIKSIEF 207 Query: 240 HLLHESLFGSVADDQKLMIWDTRNNNT---------SKPSHTVDAHTAEVNCLSFNPYSE 290 S F D+ + ++D R T + + T C F+ E Sbjct: 208 ARKG-SCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCC-FSGDGE 265 Query: 291 FILATGSADKTVALWDLRNLKLKLHSFESHKDE-IFQVQWSPHNETILASSGTDRRLHVW 349 +I+A + + +W+ +++ + + E + V W P I+AS + + +W Sbjct: 266 YIVAGSARQHALYIWE-KSIGNLVKILHGTRGELLLDVAWHP-VRPIIASISS-GVVSIW 322 >5WLC-LN nrPDB Length = 776 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 37/300 (12%), Positives = 98/300 (32%), Gaps = 39/300 (13%) Query: 141 ACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSA 200 ++ + V++ D + P G + D L + L+W + +++ Sbjct: 153 QDKLSVGCDNGTVVLIDISGGP------GVLEHDTILMRQEARVLTLAW--KKDDFVIGG 204 Query: 201 SDDHTICLWDINATPKEHRVIDAKNIF---TGHTAVVEDVAWHLLHESLFGSVADDQKLM 257 D I +W + + + +V V + S + Sbjct: 205 CSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPR-TDQIASGDSTGSIK 263 Query: 258 IWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF 317 WD + ++ + AH A+V CL+ + + ++ + D+ + + K + ++ Sbjct: 264 FWDFQFATLNQ---SFKAHDADVLCLTTDTDNNYVF-SAGVDRKIFQFSQNTNKSQKNNR 319 Query: 318 ES-------HKDEIFQV-QWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPE 369 H ++I + + L S G ++ L + L+ + P Sbjct: 320 WVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVINSLTSFSNGNYRKMPTVEPYS 379 Query: 370 LLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPE-IPASELETN 428 + + SW+ ++ +++W M + ++ + + L+ + Sbjct: 380 KNVLVNKEQRLV--VSWS------------ESTVKIWTMGTDSSTEQNYKLVCKLTLKDD 425 >5TF2-A nrPDB Length = 407 Score = 62.9 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 49/309 (15%), Positives = 93/309 (30%), Gaps = 59/309 (19%) Query: 82 HLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEG------------ 129 H + Q + E+G G+ + + + HEG Sbjct: 107 HCQLLRFQAHQQQGNKAEKAGSKEQGPRQRKGAAPAEKKCGAETQHEGLELRVENLQAVQ 166 Query: 130 ------EVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKE 183 + + + ++AT V V+ + L + H+ E Sbjct: 167 TDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVP----------SLEKVLEFKAHEGE 216 Query: 184 GYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW---- 239 L+ P+ G L++ D +W + + + F+ + + Sbjct: 217 IEDLALGPD--GKLVTVGRDLKASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVP 274 Query: 240 -HLLHESLFGSVADDQKLM--------IWDTRNNNTSKPSHTVD-AHTAEVNCLSFNPYS 289 LF ++L WD + P T H V+CL + S Sbjct: 275 DQPAGLRLFTVQIPHKRLRQPPPCYLTAWD---GSNFLPLRTKSCGHE-VVSCLDVS-ES 329 Query: 290 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP----------HNETILAS 339 L G+ +VA++ +L+ + E+H + V + P +ET L S Sbjct: 330 GTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPELLGSHETALFS 389 Query: 340 SGTDRRLHV 348 D R + Sbjct: 390 VAVDSRCQL 398 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 26/109 (23%), Positives = 47/109 (43%), Gaps = 9/109 (8%) Query: 283 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGT 342 + FN + +LATG D V +W + +L+ K+ F++H+ EI + P + L + G Sbjct: 178 VCFNHDNT-LLATGGTDGYVRVWKVPSLE-KVLEFKAHEGEIEDLALGPDGK--LVTVGR 233 Query: 343 DRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEP 391 D + VW ++Q F + + F P++P Sbjct: 234 DLKASVW-----QKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQP 277 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 21/87 (24%), Positives = 35/87 (40%), Gaps = 16/87 (18%) Query: 321 KDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAK 380 D + +V H+ T+LA+ GTD + VW + + E + H + Sbjct: 171 SDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSL--------------EKVLEFKAHEGE 216 Query: 381 ISDFSWNPNEPWIICSVSEDNIMQVWQ 407 I D + P+ + +V D VWQ Sbjct: 217 IEDLALGPDGK--LVTVGRDLKASVWQ 241 >3JB9-S nrPDB Length = 488 Score = 61.3 bits (147), Expect = 7e-10, Method: Composition-based stats. Identities = 49/278 (17%), Positives = 100/278 (35%), Gaps = 38/278 (13%) Query: 128 EGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGL 187 EG ++ + +AT + +F++ S + GE + + ++ L Sbjct: 248 EGSALACCWLTSSKIAVATAD---AISIFEFPVSSSGLQSVGEPTSSIPID---EKVNFL 301 Query: 188 SWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLF 247 +P YLL+AS++ ++ + + V H +LF Sbjct: 302 QAHP-SGEYLLAASNEK-CYIFSLKSQVYNITVAQHITSLAVH-----------PDGNLF 348 Query: 248 GSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL 307 + ++ +L ++T + N H++ V L F +++ T + D + +WDL Sbjct: 349 VAGLENGELRFFETSSGNELT---KFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDL 405 Query: 308 RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGP 367 R +L VQ P +T +A+ D + +S GE Sbjct: 406 RKSEL--------------VQKIPL-QTKVAAVSLDITSQLL-VSSDGETLYVHIYVKSS 449 Query: 368 PELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQV 405 + H + IS+ W ++ S S I+++ Sbjct: 450 KSWRCMSQTHVSSISNLVWLNELHQLLFSTSNGAILRL 487 Score = 53.6 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 27/182 (14%), Positives = 69/182 (37%), Gaps = 28/182 (15%) Query: 235 EDVAWHLLHESLFGSVADDQKLMIWDTRNNNTS-----KPSHTVDAHTAEVNCLSFNPYS 289 +A L S D + I++ +++ +P+ ++ VN L +P Sbjct: 250 SALACCWLTSSKIAVATADA-ISIFEFPVSSSGLQSVGEPTSSIPIDEK-VNFLQAHPSG 307 Query: 290 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 E++LA + ++ L++ + + H I + P + + + L + Sbjct: 308 EYLLAASNE--KCYIFSLKSQVYNI-TVAQH---ITSLAVHPDG-NLFVAGLENGELRFF 360 Query: 350 DLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMA 409 + S E L G H++ + + N W++ + ++D+ + +W + Sbjct: 361 ETSSGNE--------------LTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLR 406 Query: 410 EN 411 ++ Sbjct: 407 KS 408 >3DWL-C nrPDB Length = 377 Score = 60.6 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 28/201 (13%), Positives = 70/201 (34%), Gaps = 10/201 (4%) Query: 211 INATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPS 270 + ++ F+ H +V V W + + D+ +++ R + T K + Sbjct: 35 VELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNR-IVTCSQDRNAYVYEKRPDGTWKQT 93 Query: 271 HTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW---DLRNLKLKLHSFESHKDEIFQV 327 + + ++P + A GS + +++ + + H + I + Sbjct: 94 LVLLRLNRAATFVRWSPNED-KFAVGSGARVISVCYFEQENDWWVSKHLKRPLRSTILSL 152 Query: 328 QWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG---PPELLFIHGGHTAKISDF 384 W P+N +LA+ DR+ +V + E + G P + + Sbjct: 153 DWHPNN-VLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEYPSGGWVHAV 211 Query: 385 SWNPNEPWIICSVSEDNIMQV 405 ++P+ + D+ + + Sbjct: 212 GFSPSG-NALAYAGHDSSVTI 231 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 30/179 (16%), Positives = 62/179 (34%), Gaps = 17/179 (9%) Query: 238 AWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGS 297 A++ F + ++ +++ ++ N K + T H V C+ + P S I+ T S Sbjct: 18 AFNSQRTE-FVTTTATNQVELYE-QDGNGWKHARTFSDHDKIVTCVDWAPKSNRIV-TCS 74 Query: 298 ADKTVALWDLRNL--KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIG 355 D+ +++ R + V+WSP+ + SG R + V Sbjct: 75 QDRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGA-RVISV------- 126 Query: 356 EEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYN 414 + E+ + + I W+PN ++ + D V + Sbjct: 127 ---CYFEQENDWWVSKHLKRPLRSTILSLDWHPNN-VLLAAGCADRKAYVLSAYVRDVD 181 Score = 54.4 bits (129), Expect = 9e-08, Method: Composition-based stats. Identities = 29/200 (14%), Positives = 63/200 (31%), Gaps = 25/200 (12%) Query: 166 EPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKN 225 + + H K + W P N +++ S D +++ + Sbjct: 40 QDGNGWKHARTFSDHDKIVTCVDWAPKSNR-IVTCSQDRNAYVYE----KRPDGTWKQTL 94 Query: 226 IFTGHTAVVEDVAWHLLHESLFGSVADDQKLMI-WDTRNNNTSKPSHTVDAHTAEVNCLS 284 + V W +E F + + + + + + N+ H + + L Sbjct: 95 VLLRLNRAATFVRWSP-NEDKFAVGSGARVISVCYFEQENDWWVSKHLKRPLRSTILSLD 153 Query: 285 FNPYSEFILATGSADKTVA----------------LWDLRNLKLKLHSFESHKDEIFQVQ 328 ++P + +LA G AD+ +W R + + + V Sbjct: 154 WHPNNV-LLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEYPSGGWVHAVG 212 Query: 329 WSPHNETILASSGTDRRLHV 348 +SP LA +G D + + Sbjct: 213 FSPSGNA-LAYAGHDSSVTI 231 Score = 47.1 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 41/274 (14%), Positives = 101/274 (36%), Gaps = 40/274 (14%) Query: 127 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 186 H+ V + P++ ++ T + + V++ P G + L L + Sbjct: 54 HDKIVTCVDWAPKSNRIV-TCSQDRNAYVYE-------KRPDGTWKQTLVLLRLNRAATF 105 Query: 187 LSWNPNLNGYLL-SASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 245 + W+PN + + + S + ++C ++ + + + + + WH + Sbjct: 106 VRWSPNEDKFAVGSGARVISVCYFEQENDWWVSKHLKRPL-----RSTILSLDWHP-NNV 159 Query: 246 LFGSVADDQK----------------LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS 289 L + D+K +W +R + + V+ + F+P S Sbjct: 160 LLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEYPSG--GWVHAVGFSP-S 216 Query: 290 EFILATGSADKTVAL-WDLRNLKLK--LHSFESHKDEIFQVQWSPHNETILASSGTDRRL 346 LA D +V + + + L + + + + + W+ NE+ + ++G + Sbjct: 217 GNALAYAGHDSSVTIAYPSAPEQPPRALITVKLSQLPLRSLLWA--NESAIVAAGYNYSP 274 Query: 347 HVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAK 380 + ++ G + D + G + F H G+T + Sbjct: 275 ILLQGNESGWAHT-RDLDAGTSKTSFTHTGNTGE 307 >6CHG-D nrPDB Length = 439 Score = 58.3 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 24/111 (21%), Positives = 49/111 (44%), Gaps = 6/111 (5%) Query: 268 KPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK---LKLHSFESHKDEI 324 K +HT++ A V C+ F+P ++ LA G ++ + ++D+ +LK + +H + Sbjct: 19 KLTHTLEVPVAAV-CVKFSPRGDY-LAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSV 76 Query: 325 FQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHG 375 V WS + SSG D +WD+++ + + + Sbjct: 77 QSVCWSNDGRYLW-SSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRW 126 Score = 49.8 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 55/338 (16%), Positives = 113/338 (33%), Gaps = 54/338 (15%) Query: 120 EIEIKINHEGEV----NRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDL 175 E K+ H EV ++ P+ +A + ++++D +P Sbjct: 15 EYPEKLTHTLEVPVAAVCVKFSPR-GDYLAVGCSNGAIIIYDM----DSLKPIAMLGTHS 69 Query: 176 RLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVE 235 H + + W+ N YL S+ D LWD+ K + F G Sbjct: 70 --GAHTRSVQSVCWS-NDGRYLWSSGRDWYAKLWDMTQPTKCFQQYK----FDGPLWSCH 122 Query: 236 DVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSF------NPYS 289 V W++ +V ++ + + + + +++ + +P Sbjct: 123 VVRWNVC----IVTVVEEPTAYVLTLTDRQNAFHCFPLLEQDQDISGHGYTLVACPHPTI 178 Query: 290 EFILATGSADKTVALW------DLRNL-----KLKLHSFESHKDEIFQVQWSPHNETILA 338 E I+ TG T W DL + + ++ + I Q+ SP I A Sbjct: 179 ESIIITG----TSKGWINAFQLDLESGFEDKIRCCYEEKIANAN-IKQIIISPSGTRI-A 232 Query: 339 SSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNP------NEPW 392 +G+DR + + L I E+ +E + H + I+ WN + + Sbjct: 233 INGSDRTIRQYQL--IVEDNESEGGSSHSVSIELEHK-YQDIINRLQWNTIFFSNHSGEY 289 Query: 393 IICS--VSEDNIMQVWQMAENVYNDEEPEIPASELETN 428 ++ S S + + +W+ + L+ + Sbjct: 290 LVASAHGSSAHDLYLWETSSGSLVRVLEGADEELLDID 327 Score = 40.5 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 33/201 (16%), Positives = 66/201 (32%), Gaps = 19/201 (9%) Query: 119 IEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLR 178 +E + I+ G A P +I T T + F + C + Sbjct: 157 LEQDQDISGHGYTLVACPHPTIESIIITGTSKGWINAFQLDLESGFEDKIRCCYEEKIAN 216 Query: 179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWD--INATPKEHRVIDAKNIFTGH--TAVV 234 + +P+ ++ S D TI + + E + +I H ++ Sbjct: 217 A---NIKQIIISPSGTRIAINGS-DRTIRQYQLIVEDNESEGGSSHSVSIELEHKYQDII 272 Query: 235 EDVAWHL------LHESLFGS--VADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFN 286 + W+ E L S + L +W+T ++ ++ E+ + +N Sbjct: 273 NRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWET---SSGSLVRVLEGADEELLDIDWN 329 Query: 287 PYSEFILATGSADKTVALWDL 307 YS I + G V +W + Sbjct: 330 FYSMRIASNGFESGWVYMWSI 350 >5MC6-j nrPDB Length = 397 Score = 57.1 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 41/260 (15%), Positives = 87/260 (33%), Gaps = 41/260 (15%) Query: 142 CVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLS-- 199 C++AT + S D+L + T+ + E L + + L W N LLS Sbjct: 82 CLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKWG-ASNDRLLSHR 140 Query: 200 -ASDD--HTICLWDI----NATPKEHRVIDAKNIFTGHTAVVE-----DVAWHLLHESLF 247 + D T +W + + G + + L Sbjct: 141 LVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFATSVDISERGLI 200 Query: 248 GSVADDQKLMIWDTRNNNTSKPSHTVDAH------TAEVNCLSFNPYSEFILATGSADKT 301 + ++ + I +T +P + ++ + + + F+P +LA + Sbjct: 201 ATGFNNGTVQI---SELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGS-LLAIAHDSNS 256 Query: 302 ---VALWDLR------NLKLKLHSFES------HKDEIFQVQWSPHNETILASSGTDRRL 346 + L++ +L + HS ++ H + + ++ ET+ S+G D +L Sbjct: 257 FGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLC-SAGWDGKL 315 Query: 347 HVWDLSKIGEEQSTEDAEDG 366 WD+ + D Sbjct: 316 RFWDVKTKERITTLNMHCDD 335 Score = 48.2 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 27/151 (17%), Positives = 52/151 (34%), Gaps = 22/151 (14%) Query: 86 ASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIE---------------IKINHEGE 130 +V+ P +QF S +E+G G G ++I IN+ Sbjct: 177 GTVESPMTPSQFATSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNS 235 Query: 131 VNRARYMPQNACVIA---TKTPSS-DVLVFDYTKHPSKPE-PSGECQPDLRLRGHQKEGY 185 + ++ PQ + + + + + ++ + P+ Q L H Sbjct: 236 IRSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVM 295 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPK 216 LS+N + L SA D + WD+ + Sbjct: 296 SLSFN-DSGETLCSAGWDGKLRFWDVKTKER 325 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 35/317 (11%), Positives = 90/317 (28%), Gaps = 89/317 (28%) Query: 178 RGHQKEGYGLSWNPNLNGYLLSASDDHTICLWD---INATPKEHRVIDAKNIFTG--HTA 232 + H + + +S N + +S S D + +WD ++ + + +G H Sbjct: 13 KAHDADIFSVSAC---NSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVD 69 Query: 233 VVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHT---------VDAHTAEVNCL 283 V++ + L + + L+ + + +K + H+ L Sbjct: 70 VLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFW--AL 127 Query: 284 SFNPYSEFILAT--GSAD--KTVALWDLRNLKLKLHSFESHKDEIFQVQ------WSP-- 331 + ++ +L+ + D T +W + +S + ++Q +P Sbjct: 128 KWGASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQ 187 Query: 332 -------HNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHG--------- 375 ++A+ + + + +LS + + E I Sbjct: 188 FATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSL 247 Query: 376 -----------------------------------------GHTAKISDFSWNPNEPWII 394 H++ + S+N + + Sbjct: 248 LAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFN-DSGETL 306 Query: 395 CSVSEDNIMQVWQMAEN 411 CS D ++ W + Sbjct: 307 CSAGWDGKLRFWDVKTK 323 >4FHN-A nrPDB Length = 394 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 28/135 (20%), Positives = 51/135 (37%), Gaps = 13/135 (9%) Query: 180 HQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDV-- 237 H +G ++ +P + +L D+T+ L I + +GH V D+ Sbjct: 89 HDGDGN-VNSSPVYSLFLACVCQDNTVRL--IITKNETIITQHVLGGKSGHHNFVNDIDI 145 Query: 238 -----AWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI 292 A + L E + SV DD L+IW + P ++ + F P + Sbjct: 146 ADVYSADNRLAEQVIASVGDDCTLIIWRLTDEG---PILAGYPLSSPGISVQFRPSNPNQ 202 Query: 293 LATGSADKTVALWDL 307 L G + + ++D Sbjct: 203 LIVGERNGNIRIFDW 217 Score = 42.5 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 23/150 (15%), Positives = 48/150 (32%), Gaps = 25/150 (16%) Query: 283 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF----ESHKDEIFQVQ----WSPHNE 334 ++ +P LA D TV L +N + H + + + +S N Sbjct: 95 VNSSPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVYSADNR 154 Query: 335 ---TILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEP 391 ++AS G D L +W L+ G + + P+ P Sbjct: 155 LAEQVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGI--------------SVQFRPSNP 200 Query: 392 WIICSVSEDNIMQVWQMAENVYNDEEPEIP 421 + + ++++ N+ +E + Sbjct: 201 NQLIVGERNGNIRIFDWTLNLSAEENSQTE 230 Score = 29.4 bits (64), Expect = 3.6, Method: Composition-based stats. Identities = 24/166 (14%), Positives = 57/166 (34%), Gaps = 17/166 (10%) Query: 133 RARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSG-ECQPDLRL----------RGHQ 181 ++ P N + + ++ +FD+T + S E S E + L H Sbjct: 192 SVQFRPSNPNQLIVGERNGNIRIFDWTLNLSAEENSQTELVKNPWLLTLNTLPLVNTCHS 251 Query: 182 KEGYG----LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDV 237 + W + +L+ W++ A + + D+ G ++ +V Sbjct: 252 SGIASSLANVRWIGSDGSGILAMCKSGAWLRWNLFANNDYNEISDSTMKL-GPKNLLPNV 310 Query: 238 AWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCL 283 L SL G+ + + + T ++ ++ + + N + Sbjct: 311 QGISLFPSLLGACPHPRYMDYFATAHSQHG-LIQLINTYEKDSNSI 355 >5WLC-LS nrPDB Length = 594 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 37/136 (27%), Positives = 61/136 (44%), Gaps = 16/136 (11%) Query: 254 QKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL----RN 309 +KL I ++ N S PSH+ + LSF+P S+ +L TG DKT+ ++ + + Sbjct: 231 KKLDIVRLKDANASHPSHS------AIQSLSFHP-SKPLLLTGGYDKTLRIYHIDGKTNH 283 Query: 310 LKLKLHSFESH-KDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPP 368 L LH S + F S N+ + ++G R +H WDLS ++ ++ Sbjct: 284 LVTSLHLVGSPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLS----LENLTHSQTAKI 339 Query: 369 ELLFIHGGHTAKISDF 384 E GH + F Sbjct: 340 EKFSRLYGHESTQRSF 355 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 22/119 (18%), Positives = 41/119 (34%), Gaps = 3/119 (2%) Query: 192 NLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLF-GSV 250 N +L S+ + L+D N T + ++ + + L S Sbjct: 477 KQNRWLAVGSESGFVNLYDRNNAM-TSSTPTPVAALDQLTTTISNLQFSPDGQILCMASR 535 Query: 251 ADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 309 A L + + + T +V ++F+P +LA G+ V LW L + Sbjct: 536 AVKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGG-LLAVGNEQGKVRLWKLNH 593 Score = 44.8 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 18/117 (15%), Positives = 48/117 (41%), Gaps = 7/117 (5%) Query: 242 LHESLFGSVADDQKLMIWD---TRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI-LATGS 297 ++ + ++D ++T P +D T ++ L F+P + + +A+ + Sbjct: 477 KQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRA 536 Query: 298 ADKTVALWDLRNLKLKLH--SFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLS 352 + L L + + + + + ++ V +SP +LA ++ +W L+ Sbjct: 537 VKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGG-LLAVGNEQGKVRLWKLN 592 Score = 37.1 bits (84), Expect = 0.014, Method: Composition-based stats. Identities = 19/148 (12%), Positives = 48/148 (32%), Gaps = 20/148 (13%) Query: 143 VIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASD 202 +++T D L P K + + H LS++P+ LL+ Sbjct: 211 ILSTTYNYKDTLSNSKLLPPKKLDIVRLKDANASHPSHSA-IQSLSFHPSK-PLLLTGGY 268 Query: 203 DHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW-----HLLHESLFGSVADDQKLM 257 D T+ ++ I+ + + ++ + + +++F + + + Sbjct: 269 DKTLRIYHIDG-----KTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQNIF-TAGRRRYMH 322 Query: 258 IWDTRNNNTS-------KPSHTVDAHTA 278 WD N + + + H + Sbjct: 323 SWDLSLENLTHSQTAKIEKFSRLYGHES 350 Score = 34.4 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 16/93 (17%), Positives = 40/93 (43%), Gaps = 7/93 (7%) Query: 219 RVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTA 278 R+ DA H+A ++ +++H + L + D+ L I+ + T+ ++ + Sbjct: 237 RLKDANASHPSHSA-IQSLSFHP-SKPLLLTGGYDKTLRIYHI-DGKTNHLVTSLHLVGS 293 Query: 279 EVNCLSF----NPYSEFILATGSADKTVALWDL 307 + +F + ++ + T + + WDL Sbjct: 294 PIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDL 326 >5WLC-LW nrPDB Length = 554 Score = 55.2 bits (131), Expect = 6e-08, Method: Composition-based stats. Identities = 44/218 (20%), Positives = 87/218 (39%), Gaps = 23/218 (10%) Query: 176 RLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVE 235 RL+ H E L + P + L++A + + D++ ++ G T + Sbjct: 186 RLKQHI-EARHLDFLP-YHYLLVTAGETGWLKYHDVSTGQ----LVSELRTKAGPTMAMA 239 Query: 236 DVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILAT 295 W+ + + + +W + + +P + + VN ++ + S + +AT Sbjct: 240 QNPWNAVMHL----GHSNGTVSLW---SPSMPEPLVKLLSARGPVNSIAID-RSGYYMAT 291 Query: 296 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWD--LSK 353 AD+++ +WD+RN K +LHS ES V S +LA S + +W L Sbjct: 292 TGADRSMKIWDIRNFK-QLHSVESLPTPGTNVSISDTG--LLALSRGPH-VTLWKDALKL 347 Query: 354 IGEEQSTEDAEDGPPELLFIHGGH---TAKISDFSWNP 388 G+ + + G P + H K+ + + P Sbjct: 348 SGDSKPCFGSMGGNPHRNTPYMSHLFAGNKVENLGFVP 385 Score = 41.7 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 32/222 (14%), Positives = 66/222 (29%), Gaps = 34/222 (15%) Query: 187 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 246 + + N L++ H + D + + T H+A +L +E Sbjct: 116 IKYAKNGTHLLITGRKGHVASM-DWRKGQLRAELFLNE---TCHSAT------YLQNEQY 165 Query: 247 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 306 F VA + I+D + ++A L F PY ++L T + D Sbjct: 166 FA-VAQKKYTFIYDHEGTELHRLKQHIEA-----RHLDFLPY-HYLLVTAGETGWLKYHD 218 Query: 307 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 366 + +L + + + +P N + + +W S A Sbjct: 219 VSTGQL-VSELRTKAGPTMAMAQNPWNAVMHLGHSN-GTVSLWSPSMPEPLVKLLSARGP 276 Query: 367 PPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 + G + + + D M++W + Sbjct: 277 VNSIAIDRSG---------------YYMATTGADRSMKIWDI 303 >6CVZ-A nrPDB Length = 351 Score = 52.5 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 24/108 (22%), Positives = 42/108 (38%), Gaps = 8/108 (7%) Query: 180 HQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW 239 H K+ GL+++ L G LLSAS D+TI L + + V W Sbjct: 73 HGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNAGR--------PVWSCCW 124 Query: 240 HLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP 287 L + + + ++++D RN ++ + LS+ P Sbjct: 125 CLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMP 172 Score = 48.6 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 17/109 (15%), Positives = 41/109 (37%), Gaps = 2/109 (1%) Query: 263 NNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKD 322 + K S + H ++ L+F+ Y +L + S D T+ L L + + ++ + Sbjct: 60 STANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTV-VQTYNA-GR 117 Query: 323 EIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELL 371 ++ W + + + + V+D+ A+ L+ Sbjct: 118 PVWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLV 166 Score = 34.8 bits (78), Expect = 0.072, Method: Composition-based stats. Identities = 34/263 (12%), Positives = 79/263 (30%), Gaps = 45/263 (17%) Query: 127 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 186 H ++ + ++ + + + + + E ++ + + Sbjct: 73 HGKQIRGLAFSSYLRGLLLSASLDNTIKLTSL-----------ETNTVVQTYNAGRPVWS 121 Query: 187 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNI---FTGHTAVVEDVAWHLLH 243 W + Y+ + + +I ++D+ T + + A+ + + + + Sbjct: 122 CCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAASAAFPY 181 Query: 244 ESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADK--- 300 + +D W+ + + + P H + S L T DK Sbjct: 182 GGVLAGTLED--ASFWEQKMDFSHWP-HVLPLEPGGCIDFQTENSSRHCLVTYRPDKNHT 238 Query: 301 TV---------ALWDLRNL---KLKLHSFESH-------KDEIFQVQWSPHNETILASSG 341 T+ L D N +H+F K+ IFQ SP N+ + Sbjct: 239 TIRSVLMEMSYRLDDTGNPICSCQPVHTFFGGPTCKLLTKNAIFQ---SPENDGNILVCT 295 Query: 342 TD---RRLHVWDLSKIGEEQSTE 361 D +WD + Q + Sbjct: 296 GDEAANSALLWDAASGSLLQDLQ 318 Score = 30.9 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 7/37 (18%), Positives = 17/37 (45%) Query: 377 HTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVY 413 H +I +++ ++ S S DN +++ + N Sbjct: 73 HGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTV 109 >5LTD-A nrPDB Length = 525 Score = 52.5 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 25/113 (22%), Positives = 55/113 (48%), Gaps = 9/113 (7%) Query: 256 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTV-ALWDLRNLKLKL 314 ++I+D + T +P+ ++AH + ++ + +LAT S T+ ++ + +KL Sbjct: 204 VIIFDAK---TLQPTSVIEAHRTSLAAIALSKDG-LLLATASDKGTIIRVFSVATG-IKL 258 Query: 315 HSFESHKDE--IFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED 365 + F I+ + +SP N ++ASS T +H++ L + + + A Sbjct: 259 YQFRRGTYPTKIYSLAFSPDNRFVIASSAT-ETVHIFRLGEEEAANTIKSANK 310 Score = 42.9 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 31/179 (17%), Positives = 70/179 (39%), Gaps = 41/179 (22%) Query: 255 KLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEF-ILATGSADK------------- 300 + I+D N + HT++ + ++ +P SE LA S K Sbjct: 138 TIYIYDI---NNMRLLHTIETPSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHS 194 Query: 301 ---TVA-----LWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL-HVWDL 351 TV ++D + L+ E+H+ + + S + +LA++ + V+ + Sbjct: 195 NPQTVRNGDVIIFDAKTLQ-PTSVIEAHRTSLAAIALS-KDGLLLATASDKGTIIRVFSV 252 Query: 352 SKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 410 + G F G + KI +++P+ ++I S + + + ++++ E Sbjct: 253 AT------------GIKLYQFRRGTYPTKIYSLAFSPDNRFVIASSATE-TVHIFRLGE 298 Score = 30.9 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 21/155 (13%), Positives = 54/155 (34%), Gaps = 16/155 (10%) Query: 71 ILGTHTSDEQNHLLIASVQL----PSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKIN 126 ++ S E N+L S Q P + + G+ F + ++ I Sbjct: 162 LIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQTVRNGDVIIFDA--KTLQPTSVIE 219 Query: 127 HEGEVNRARYMPQNACVIATKTPSSDVL-VFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 185 A + ++ ++AT + ++ VF + P + Y Sbjct: 220 AHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPT--------KIY 271 Query: 186 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRV 220 L+++P+ + S++ + T+ ++ + + + Sbjct: 272 SLAFSPDNRFVIASSATE-TVHIFRLGEEEAANTI 305 >2VDU-B nrPDB Length = 450 Score = 52.1 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 25/198 (12%), Positives = 65/198 (32%), Gaps = 13/198 (6%) Query: 182 KEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHL 241 L + + + A D ++ ++D++ T K + + F + ++ Sbjct: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCF---SKRPNAISIAE 159 Query: 242 LHESLFGSVADDQKLMIWDTRNNNTSKPSHT---VDAHTAEVNCLSFNPYSE--FILATG 296 ++ + D+ ++ N+ + T + H + + + S+ + T Sbjct: 160 DDTTVIIA---DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITS 216 Query: 297 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGE 356 D+ + + + HK + + +L S+G D ++ WD Sbjct: 217 DRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKD--YLLLSAGGDDKIFAWDWKTGKN 274 Query: 357 EQSTEDAEDGPPELLFIH 374 + + P L H Sbjct: 275 LSTFDYNSLIKPYLNDQH 292 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 27/193 (13%), Positives = 62/193 (32%), Gaps = 17/193 (8%) Query: 131 VNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWN 190 + R + +IA +LVFD + + + K +S Sbjct: 105 IRNLRLTSDESRLIACADSDKSLLVFDV---DKTSKNVLKLRKRFCFS---KRPNAISIA 158 Query: 191 PNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW--HLLHESLFG 248 + +++ D ++ I+ + I GH +++ DV Sbjct: 159 EDDTTVIIA---DKFGDVYSIDINSIPEEKFTQEPIL-GHVSMLTDVHLIKDSDGHQFII 214 Query: 249 SVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 308 + D+ + I + + H V+ + +++L + D + WD + Sbjct: 215 TSDRDEHIKI--SHYPQCFIVDKWLFGHKHFVSSI--CCGKDYLLLSAGGDDKIFAWDWK 270 Query: 309 NLKLKLHSFESHK 321 K L +F+ + Sbjct: 271 TGK-NLSTFDYNS 282 >6IYY-A nrPDB Length = 317 Score = 47.1 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 22/162 (13%), Positives = 57/162 (35%), Gaps = 9/162 (5%) Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDV-LVFDYTKHPSKPEPSGECQPDLRLRGHQKEG 184 H+ V Y P+ CV+ + +S + +T H + + +P + + H+ Sbjct: 120 PHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEGVL 179 Query: 185 YGLSWNPNLNGYLLSASDDHT-ICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLH 243 ++ N + +AS+ T I ++D ++ + A + + ++ Sbjct: 180 SCIALN-LQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQ-----AANIYCINFNQDA 233 Query: 244 ESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSF 285 + S +D + I+ + + + +F Sbjct: 234 SLICVS-SDHGTVHIFAAEDPKSKWSFSKFQVPSGSPCICAF 274 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 31/235 (13%), Positives = 65/235 (27%), Gaps = 16/235 (6%) Query: 194 NGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADD 253 N L + +WD + I + V+ V + D Sbjct: 61 NYLALVGGGKKKVMIWD--------DLKKKTVIEIEFSTEVKAVKLRRDRIVVVL----D 108 Query: 254 QKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK 313 + ++ +N + + L N + + G+ V L DL + + Sbjct: 109 SMIKVFTFTHNPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKP 168 Query: 314 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFI 373 +H+ + + + I +S + ++D S Q Sbjct: 169 PVDIPAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCIN 228 Query: 374 HGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETN 428 + I + + + +ED + W ++ P I A E N Sbjct: 229 FNQDASLI---CVSSDHGTVHIFAAEDPKSK-WSFSKFQVPSGSPCICAFGTEPN 279 >5WLC-LV nrPDB Length = 707 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 52/364 (14%), Positives = 118/364 (32%), Gaps = 59/364 (16%) Query: 70 LILGTHTSDEQNHLLIASVQ----LPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKI 125 ++L + ++++ + ++ LP A+ N+ ++E+ Sbjct: 1 MVLKSTSANDVSVYQVSGTNVSRSLPDWIAKKRKRQLKNDLEYQ-------NRVELIQDF 53 Query: 126 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQP--------DLRL 177 N+ + +AT T + V+D+ K + + + D Sbjct: 54 EFSEASNKIKVSRDGQYCMATGTYKPQIHVYDFANLSLKFDRHTDAENVDFTILSDDWTK 113 Query: 178 RGHQKEGYGLSWN-----------PNLNGYLLSASDDHT-ICLWDINATPKEHRVIDAKN 225 H + + + P L+ + L+ + + +R+ K Sbjct: 114 SVHLQNDRSIQFQNKGGLHYTTRIPKFGRSLV---YNKVNCDLYVGASGNELYRLNLEKG 170 Query: 226 IFTGH----TAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHT---VDAHTA 278 F T V V+ + ++ L + + + WD R+ + + +D Sbjct: 171 RFLNPFKLDTEGVNHVSINEVN-GLLAAGTETNVVEFWDPRSRSRVSKLYLENNIDNRPF 229 Query: 279 EVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET--I 336 +V SF A G+++ ++DLR + + + + +I ++ W + T Sbjct: 230 QVTTTSF-RNDGLTFACGTSNGYSYIYDLRTSEPSIIKDQGYGFDIKKIIWLDNVGTENK 288 Query: 337 LASSGTDRRL-HVWDLSKIGEEQSTEDAEDGPPELLFIHGG-----------HTAKISDF 384 + + D+R+ +WD S E + D G HT I Sbjct: 289 IVTC--DKRIAKIWDRLDGKAYASMEPSVDINDIEHVPGTGMFFTANESIPMHTYYIPSL 346 Query: 385 SWNP 388 +P Sbjct: 347 GPSP 350 >3WJ9-A nrPDB Length = 412 Score = 45.5 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 27/129 (20%), Positives = 52/129 (40%), Gaps = 16/129 (12%) Query: 232 AVVEDVAWHLLHESL-FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSE 290 + DV W+ + K I+D R N S A N L F+P S Sbjct: 269 GPIHDVCWNADSKEFGIVYGYMPAKTAIFDNRANVVSIIP------PAPRNTLIFSPNSR 322 Query: 291 FILATGSAD--KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGT-----D 343 +IL G + ++ ++D N K+ + E+ ++SP ++ +L + + D Sbjct: 323 YILLAGFGNLQGSIDIFDAANNMKKITTVEA--ANCTYCEFSPDSQFLLTAVTSPRLRVD 380 Query: 344 RRLHVWDLS 352 + +W ++ Sbjct: 381 NSIKIWHIT 389 >4AV8-A nrPDB Length = 339 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 31/154 (20%), Positives = 54/154 (35%), Gaps = 11/154 (7%) Query: 273 VDAHTAEVNCLSFNPYSEFILATGSADKT-VALWDLRNLKLKLHSFES-HKDEIFQVQWS 330 V AH V + N + +AT S D T + ++ N L + I ++WS Sbjct: 175 VKAHANPVKMVRLNRKGDM-VATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWS 233 Query: 331 PHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNE 390 P + S LHV+++ E + + + S N+ Sbjct: 234 PDGSKLAVVSDK-WTLHVFEVFNDAENKRHVLKDWINIKYFQSEWSICNFKLKVSKGSND 292 Query: 391 PWIICSVSEDNIMQVW------QMAENVYNDEEP 418 I +S+ ++ VW + YND+E Sbjct: 293 CK-IAWISDTGLVIVWPNRRLADTFKLNYNDDEH 325 Score = 35.5 bits (80), Expect = 0.048, Method: Composition-based stats. Identities = 18/112 (16%), Positives = 40/112 (35%), Gaps = 13/112 (11%) Query: 306 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED 365 D + K ++H + + V+ + + ++A+ D L ++ Sbjct: 164 DAEQVVGKGVLVKAHANPVKMVRLNRKGD-MVATCSQDGTL-----------IRVFQTDN 211 Query: 366 GPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEE 417 G F G I D W+P+ + VS+ + V+++ + N Sbjct: 212 GVLVREFRRGLDRTSIIDMRWSPDGSKL-AVVSDKWTLHVFEVFNDAENKRH 262 Score = 33.2 bits (74), Expect = 0.25, Method: Composition-based stats. Identities = 20/133 (15%), Positives = 42/133 (31%), Gaps = 17/133 (12%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHT-ICLWDINATPKEHRVIDAKNIFTGHTAVVE 235 ++ H + N + + S D T I ++ + + + Sbjct: 175 VKAHANPVKMVRLNRK-GDMVATCSQDGTLIRVFQTDNGVLVREFRRGLD-----RTSII 228 Query: 236 DVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFN-----PYSE 290 D+ W L V+D L +++ N+ H + +N F + Sbjct: 229 DMRWSPDGSKL-AVVSDKWTLHVFEV-FNDAENKRHVL---KDWINIKYFQSEWSICNFK 283 Query: 291 FILATGSADKTVA 303 ++ GS D +A Sbjct: 284 LKVSKGSNDCKIA 296 Score = 29.8 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 18/110 (16%), Positives = 44/110 (40%), Gaps = 8/110 (7%) Query: 218 HRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK-LMIWDTRNNNTSKPSHTVDAH 276 +V+ + H V+ V + + + + + D + ++ T N + Sbjct: 166 EQVVGKGVLVKAHANPVKMVRLNRKGD-MVATCSQDGTLIRVFQTDNGVLVREFRRGLDR 224 Query: 277 TAEVNCLSFNPYSEFILATGSADKTVALWDL-RNLKLKLHSFESHKDEIF 325 T+ ++ + ++P LA S T+ ++++ + + K H KD I Sbjct: 225 TSIID-MRWSPDGS-KLAVVSDKWTLHVFEVFNDAENKRHVL---KDWIN 269 >2I3T-A nrPDB Length = 341 Score = 42.5 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 38/286 (13%), Positives = 90/286 (31%), Gaps = 70/286 (24%) Query: 118 KIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRL 177 +++ + ++ + ++ I T ++L D PS L Sbjct: 46 NVDLLQSLRYKHPLLCCNFIDNTDLQIYVGTVQGEILKVDLIGSPSFQA----------L 95 Query: 178 RGHQKEGYGLSWNPNLNGYLLSASDDHTICLWD---------------INATPKEHRVID 222 ++ + L++AS D I + D N T ++++ Sbjct: 96 TNNEANLGICRICKYGDDKLIAASWDGLIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFT 155 Query: 223 AKNIFT-----------------------------GHTAVVEDVAWHLLHESLFGSVADD 253 + G + DVA + + + D Sbjct: 156 MDTNSSRLIVGMNNSQVQWFRLPLCEDDNGTIEESGLKYQIRDVALLPKEQEGYACSSID 215 Query: 254 QKLMI--WDTRNNNTSKPSH-TVDAHTA---------EVNCLSFNPYSEFILATGSADKT 301 ++ + +D + ++ + H VN + F+P +F L T +D Sbjct: 216 GRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTNLAYPVNSIEFSPRHKF-LYTAGSDGI 274 Query: 302 VALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLH 347 ++ W+L+ K + + ++D + ++ S + IL + +D Sbjct: 275 ISCWNLQTRKKIKNFAKFNEDSVVKIACS---DNILCLATSDDTFK 317 >5WLC-LH nrPDB Length = 896 Score = 41.3 bits (95), Expect = 8e-04, Method: Composition-based stats. Identities = 23/144 (15%), Positives = 58/144 (40%), Gaps = 5/144 (3%) Query: 235 EDVAWHLLHESLFGSVA-DDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFIL 293 +DV+ V+ D + + + S + ++ +T V+ ++ + + L Sbjct: 213 KDVSTKDHEHKSISVVSLFDDSVNLSFPLGSILSSQTQSLSYNTRYVSSMAIDNMGQQ-L 271 Query: 294 ATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSK 353 A G A +++ L +L+++L + H D + + +S +L S G ++ + +W L Sbjct: 272 AVGFASGVISIVSLADLQIRL--LKWHIDSVLSLSFSHDGSYLL-SGGWEKVMSLWQLET 328 Query: 354 IGEEQSTEDAEDGPPELLFIHGGH 377 ++ + G+ Sbjct: 329 NSQQFLPRLNGIIIDCQVLGPQGN 352 Score = 35.5 bits (80), Expect = 0.042, Method: Composition-based stats. Identities = 10/42 (23%), Positives = 19/42 (45%), Gaps = 1/42 (2%) Query: 177 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEH 218 L+ H LS++ + YLLS + + LW + ++ Sbjct: 293 LKWHIDSVLSLSFS-HDGSYLLSGGWEKVMSLWQLETNSQQF 333 Score = 32.8 bits (73), Expect = 0.32, Method: Composition-based stats. Identities = 7/35 (20%), Positives = 18/35 (51%), Gaps = 1/35 (2%) Query: 377 HTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 411 H + S++ + +++ S + +M +WQ+ N Sbjct: 296 HIDSVLSLSFSHDGSYLL-SGGWEKVMSLWQLETN 329 >5AMS-A nrPDB Length = 431 Score = 39.8 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 14/91 (15%), Positives = 33/91 (36%), Gaps = 13/91 (14%) Query: 313 KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLF 372 L F+ H D +F + P+ ++ + G D H+W + PP+ Sbjct: 57 SLTYFDKHTDSVFAIGHHPNLP-LVCTGGGDNLAHLW------------TSHSQPPKFAG 103 Query: 373 IHGGHTAKISDFSWNPNEPWIICSVSEDNIM 403 G+ + S+ +++ + ++ Sbjct: 104 TLTGYGESVISCSFTSEGGFLVTADMSGKVL 134 Score = 38.6 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 48/341 (14%), Positives = 106/341 (31%), Gaps = 52/341 (15%) Query: 71 ILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEI-EIKINHEG 129 ++ T D HL + Q P G F G ++ + H G Sbjct: 79 LVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMG 138 Query: 130 EVNRARY-----------------MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQ 172 + A++ P A A V + + E Sbjct: 139 QKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQL---- 194 Query: 173 PDLRLRG--HQKEGYGLSW-NPNLNGY---LLSASDDHTICLWDINATPKEHRVIDAKNI 226 + G HQ++ + N + L++ S D TI W+ + ++ + Sbjct: 195 ----MSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKI--TQAE 248 Query: 227 FTGHTAVVEDVAWHLL-----HESLFGSVADDQKLMIWDTRNNNTSKPSHTV-------D 274 G A ++ + + +++ L + + N TV D Sbjct: 249 IKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVIELKPEQD 308 Query: 275 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE 334 A + +S++ ++A G + L+D + H F +D + ++ + + Sbjct: 309 ELDASIESISWSSKFS-LMAIGLVCGEILLYDT-SAWRVRHKFVL-EDSVTKLMFDNDD- 364 Query: 335 TILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHG 375 L +S + +++ ++ E+ G + + +H Sbjct: 365 --LFASCINGKVYQFNARTGQEKFVCVGHNMGVLDFILLHP 403 Score = 37.8 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 19/124 (15%), Positives = 44/124 (35%), Gaps = 4/124 (3%) Query: 273 VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH-SFESHKDEIFQVQWSP 331 D HT V + +P + ++ TG D LW + K + + + + ++ Sbjct: 61 FDKHTDSVFAIGHHP-NLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTS 119 Query: 332 HNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEP 391 L ++ ++ V + + G Q ++ E + H F++ + Sbjct: 120 EGG-FLVTADMSGKVLV-HMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDG 177 Query: 392 WIIC 395 + C Sbjct: 178 SVWC 181 Score = 33.2 bits (74), Expect = 0.25, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 17/44 (38%), Gaps = 1/44 (2%) Query: 363 AEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 406 D L HT + +PN P + C+ DN+ +W Sbjct: 50 EVDMSNNSLTYFDKHTDSVFAIGHHPNLPLV-CTGGGDNLAHLW 92 >5K1H-B nrPDB Length = 576 Score = 38.6 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 16/102 (15%), Positives = 37/102 (36%), Gaps = 12/102 (11%) Query: 255 KLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATG--SADKTVALWDLRNLKL 312 + + ++N + S D + N + ++P +F++ G S + +A + Sbjct: 419 SVSFYHVKSNGKIELSKMFD--KQQANTIFWSPQGQFVVLAGLRSMNGALAF--VDTSDC 474 Query: 313 KLHSFESHKDEIFQVQWSPHNETILASSGT-----DRRLHVW 349 + + H V+W P ++ S D +W Sbjct: 475 TVMNIAEHYMA-SDVEWDPTGRYVVTSVSWWSHKVDNAYWLW 515 Score = 30.1 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 40/255 (15%), Positives = 77/255 (30%), Gaps = 39/255 (15%) Query: 182 KEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHL 241 SW+P N +D DI A ++ + I + V D H Sbjct: 296 SGIKDFSWSPGGNIIAFWVPEDK-----DIPARVTLMQLPSRQEIRVRNLFNVVDCKLHW 350 Query: 242 LHESLFGSVADDQKLM----------IWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSE- 290 + V D+ I+ R + + ++ P Sbjct: 351 QKNGDYLCVKVDRTPKGTQGVVTNFEIFRMREKQVPVDVVEM---KETIIAFAWEPNGSK 407 Query: 291 FILATGSADK-TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 349 F + G A + +V+ + +++ S K + + WSP + ++ + Sbjct: 408 FAVLHGEAPRISVSFYHVKSNGKIELSKMFDKQQANTIFWSPQGQFVVLAG--------- 458 Query: 350 DLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSE-----DNIMQ 404 L + + D D + H SD W+P +++ SVS DN Sbjct: 459 -LRSMNGALAFVDTSDCTVMNIAEHY----MASDVEWDPTGRYVVTSVSWWSHKVDNAYW 513 Query: 405 VWQMAENVYNDEEPE 419 +W + + Sbjct: 514 LWTFQGRLLQKNNKD 528 >6N8P-A nrPDB Length = 979 Score = 38.2 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 38/249 (15%), Positives = 76/249 (30%), Gaps = 51/249 (20%) Query: 143 VIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRG-HQ--KEGYGLSWNPNLNGYLLS 199 ++A T S + ++ P + G HQ + P L++ Sbjct: 35 ILAIGTRSGAIKLYGA--------------PGVEFMGLHQENNAVTQIHLLPGQCQ-LVT 79 Query: 200 ASDDHTICLWDIN-ATPKEHRVIDAKNIFTGH------TAVVEDVAWHLLHESL-FGSVA 251 DD+++ LW + D G + V H E L G+ + Sbjct: 80 LLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTES 139 Query: 252 --------------DDQKLMIWDTRNNNTSKPSHTVDAHTAE---VNCLSFNPYSEFILA 294 +D+ + ++ + H V L +P + Sbjct: 140 GNVFVVQLPAFRALEDRTIS-----SDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQIL 194 Query: 295 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKI 354 G + V +WDL+ ++ H S + + W + +L S +D W +S Sbjct: 195 IGYSRGLVVIWDLQGSRVLYHFLSSQQ---LENIWWQRDGRLLVSCHSDGSYCQWPVSSE 251 Query: 355 GEEQSTEDA 363 ++ + Sbjct: 252 AQQPEPLRS 260 Score = 35.9 bits (81), Expect = 0.034, Method: Composition-based stats. Identities = 47/356 (13%), Positives = 98/356 (27%), Gaps = 85/356 (23%) Query: 65 YSVHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIK 124 S L LGT + + + VQLP+ A + ++ + + Sbjct: 128 SSCELLYLGTESGN------VFVVQLPAFRA-LEDRTISSDAVLQ----------RLPEE 170 Query: 125 INHE---GEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQ 181 H V + P++ I V+++D Q + Sbjct: 171 ARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENI----- 225 Query: 182 KEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIF-TGHTAVVEDVAWH 240 W L+S D + C W +++ ++ + + + + + W Sbjct: 226 -------WWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWL 278 Query: 241 LLHESL------------------FGSVADDQKLMIWDTRNNNTS--------------K 268 + L SV D + +D + Sbjct: 279 TTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDD 338 Query: 269 PSHTVDAHTAEVNCLS-----FNPYSEFILA-------TGS---ADKTVALWD--LRNLK 311 P V E+ + + P LA T S ++ + LW+ + Sbjct: 339 PYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGS 398 Query: 312 LKLHSFESHKDEI---FQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAE 364 + F + + I + +P +L + D + WD S + + + Sbjct: 399 RQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLST 454 >4YHC-A nrPDB Length = 468 Score = 33.2 bits (74), Expect = 0.25, Method: Composition-based stats. Identities = 17/66 (25%), Positives = 27/66 (40%), Gaps = 1/66 (1%) Query: 320 HKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTA 379 H+ +I ++ S + +T AS G DR L VWDL + + + Sbjct: 29 HQLDILKIAVSENYKT-FASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 380 KISDFS 385 +S FS Sbjct: 88 YVSLFS 93 Score = 32.8 bits (73), Expect = 0.33, Method: Composition-based stats. Identities = 24/103 (23%), Positives = 46/103 (44%), Gaps = 5/103 (4%) Query: 230 HTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS 289 H + +A ++ F SV D+ L++WD R T K + + + ++ +P Sbjct: 29 HQLDILKIAVSENYK-TFASVGLDRSLVVWDLRQWCT-KLVLSKEQMPRTLKAIALDPQG 86 Query: 290 EFILATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWSP 331 ++ S D T+ + ++ + L L HS+ S + V W P Sbjct: 87 NYVSLF-SKD-TLFILNVESPSLMLQHSYHSKPNSKLNVFWMP 127 >5CWW-B nrPDB Length = 595 Score = 32.5 bits (72), Expect = 0.36, Method: Composition-based stats. Identities = 20/139 (14%), Positives = 38/139 (27%), Gaps = 18/139 (12%) Query: 129 GEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLS 188 G + + AT ++ + S L H L Sbjct: 86 GPTSTKKDSSDFDDGAATAGY--RIIKTPVADDIRQLVMSPNQDFLAVLTSHTVHICIL- 142 Query: 189 WNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLL--HESL 246 P+ + + D + + T +AVV V WH L + Sbjct: 143 --PDSSHL----------HIQDTTPFKPKFWTLGPTTHVTSRSAVVSAV-WHPLGVNGHA 189 Query: 247 FGSVADDQKLMIWDTRNNN 265 +V +D + +W+ + Sbjct: 190 LVTVTEDAIVRVWELSTAD 208 Score = 32.5 bits (72), Expect = 0.38, Method: Composition-based stats. Identities = 17/94 (18%), Positives = 37/94 (39%), Gaps = 7/94 (7%) Query: 322 DEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGH---T 378 D+I Q+ SP+ + + + +H+ L + P H Sbjct: 115 DDIRQLVMSPNQDFLAVLTS--HTVHICILPDSSHLHIQDTTPFKPKFWTLGPTTHVTSR 172 Query: 379 AKISDFSWNPNE--PWIICSVSEDNIMQVWQMAE 410 + + W+P + +V+ED I++VW+++ Sbjct: 173 SAVVSAVWHPLGVNGHALVTVTEDAIVRVWELST 206 Score = 30.9 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 18/94 (19%), Positives = 30/94 (31%), Gaps = 20/94 (21%) Query: 278 AEVNCLSFNPYSEFILATGSADKTVALW-----------DLRNLKLKLHSFES--H---K 321 ++ L +P +F+ S TV + D K K + H + Sbjct: 115 DDIRQLVMSPNQDFLAVLTS--HTVHICILPDSSHLHIQDTTPFKPKFWTLGPTTHVTSR 172 Query: 322 DEIFQVQWSPHN--ETILASSGTDRRLHVWDLSK 353 + W P L + D + VW+LS Sbjct: 173 SAVVSAVWHPLGVNGHALVTVTEDAIVRVWELST 206 >5BPW-A nrPDB Length = 843 Score = 32.5 bits (72), Expect = 0.40, Method: Composition-based stats. Identities = 22/119 (18%), Positives = 46/119 (38%), Gaps = 12/119 (10%) Query: 170 ECQPDLRLRGHQK---EGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNI 226 C P R+ G ++ E L W+P + + A+ + L + + + +N Sbjct: 6 TCFPSFRVVGEKQLPQEIIFLVWSPKRD-LIALANTAGEVLLHRLASFHRVWSFPPNENT 64 Query: 227 FTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSF 285 V +AW + L ++AD +K+++ D + A V+C+ + Sbjct: 65 ----GKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSV----EAPVSCMHW 115 Score = 30.9 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 19/74 (25%), Positives = 31/74 (41%), Gaps = 13/74 (17%) Query: 257 MIWDTR-NNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 315 +W N NT K EV CL++ P + + + K + L D+ + LH Sbjct: 54 RVWSFPPNENTGK----------EVTCLAWRPDGKLLAFALADTKKIVLCDVEKPE-SLH 102 Query: 316 SFESHKDEIFQVQW 329 SF S + + + W Sbjct: 103 SF-SVEAPVSCMHW 115 Score = 29.0 bits (63), Expect = 3.8, Method: Composition-based stats. Identities = 12/54 (22%), Positives = 18/54 (33%) Query: 182 KEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVE 235 KE L+W P+ + +D I L D+ H + H V Sbjct: 66 KEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSVEAPVSCMHWMEVT 119 >2YNZ-A nrPDB Length = 154 Score = 32.5 bits (72), Expect = 0.41, Method: Composition-based stats. Identities = 14/56 (25%), Positives = 24/56 (42%) Query: 67 VHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIE 122 + +LI T+ +QN IA + + D +D+E+G F G +I Sbjct: 25 IKKLIYETNQKVDQNTSAIADINTSITNLGTDALSWDDEEGAFSASHGTSGTNKIT 80 >5AJA-A nrPDB Length = 361 Score = 32.1 bits (71), Expect = 0.47, Method: Composition-based stats. Identities = 11/62 (17%), Positives = 28/62 (45%), Gaps = 2/62 (3%) Query: 281 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 340 C +F+ F++ G+ + L+++ + + + S+ H I ++ S +L S+ Sbjct: 41 TCCAFSARERFLML-GTCTGQLKLYNVFSGQEE-ASYNCHNSAITHLEPSRDGSLLLTSA 98 Query: 341 GT 342 Sbjct: 99 TW 100 >4NOX-A nrPDB Length = 746 Score = 31.7 bits (70), Expect = 0.58, Method: Composition-based stats. Identities = 26/174 (14%), Positives = 51/174 (29%), Gaps = 30/174 (17%) Query: 262 RNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILA-----TGSADKTVALWDL--------- 307 + N H N + ++P F++ T S+D + WDL Sbjct: 506 KGNQVGSFKHLRTLEKKNHNAIYWSPKGRFVVIATVHNTQSSD--LEFWDLDFDGEKPEN 563 Query: 308 -RNLKLKLHSF-ESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED 365 ++L L I V+W P + + W + Sbjct: 564 EKDLAACLQLMGTGDHYGITDVEWDPSGRYVATWASA------W------KHTMENGYHL 611 Query: 366 GPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPE 419 + + H K + W P P ++ + I + + ++ E+ E Sbjct: 612 YDFKGELLREEHIEKFKQWQWRPRPPTLLTKEEQKQIRKNLREYSRIFEQEDAE 665 >5GRS-A nrPDB Length = 396 Score = 31.7 bits (70), Expect = 0.68, Method: Composition-based stats. Identities = 17/66 (25%), Positives = 27/66 (40%), Gaps = 1/66 (1%) Query: 320 HKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTA 379 H+ +I ++ S + +T AS G DR L VWDL + + + Sbjct: 29 HQLDILKIAVSENYKT-FASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 380 KISDFS 385 +S FS Sbjct: 88 YVSLFS 93 Score = 31.7 bits (70), Expect = 0.71, Method: Composition-based stats. Identities = 18/86 (20%), Positives = 38/86 (44%), Gaps = 4/86 (4%) Query: 230 HTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS 289 H + +A ++ F SV D+ L++WD R T K + + + ++ +P Sbjct: 29 HQLDILKIAVSENYK-TFASVGLDRCLVVWDLRQWCT-KLVLSKEQMPRTLKAIALDPQG 86 Query: 290 EFILATGSADKTVALWDLRNLKLKLH 315 ++ S D T+ + ++ + L L Sbjct: 87 NYVSLF-SKD-TLFILNVESPSLMLQ 110 >5ODS-A nrPDB Length = 574 Score = 31.7 bits (70), Expect = 0.69, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 25/69 (36%), Gaps = 7/69 (10%) Query: 254 QKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK 313 + L I++ + K HT+ T +V + + L T D V W + Sbjct: 86 KTLQIFNIEMKSKMKA-HTM---TDDVTFWKWISLNTVALVT---DNAVYHWSMEGESQP 138 Query: 314 LHSFESHKD 322 + F+ H Sbjct: 139 VKMFDRHSS 147 >4G55-A nrPDB Length = 369 Score = 31.7 bits (70), Expect = 0.69, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 25/69 (36%), Gaps = 7/69 (10%) Query: 254 QKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK 313 + L I++ + K HT+ T +V + + L T D V W + Sbjct: 91 KTLQIFNIEMKSKMKA-HTM---TDDVTFWKWISLNTVALVT---DNAVYHWSMEGESQP 143 Query: 314 LHSFESHKD 322 + F+ H Sbjct: 144 VKMFDRHSS 152 >1BPO-A nrPDB Length = 494 Score = 31.7 bits (70), Expect = 0.69, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 25/69 (36%), Gaps = 7/69 (10%) Query: 254 QKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK 313 + L I++ + K HT+ T +V + + L T D V W + Sbjct: 86 KTLQIFNIEMKSKMKA-HTM---TDDVTFWKWISLNTVALVT---DNAVYHWSMEGESQP 138 Query: 314 LHSFESHKD 322 + F+ H Sbjct: 139 VKMFDRHSS 147 >5HAX-A nrPDB Length = 742 Score = 31.7 bits (70), Expect = 0.71, Method: Composition-based stats. Identities = 10/43 (23%), Positives = 16/43 (37%) Query: 296 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 338 S D ++ LWD + +L +E I V P + Sbjct: 86 ASIDSSLFLWDYTHPNPELIGYEEATHTITAVALVPPKPGVFV 128 >2PFR-A nrPDB Length = 294 Score = 31.7 bits (70), Expect = 0.73, Method: Composition-based stats. Identities = 14/78 (17%), Positives = 29/78 (37%), Gaps = 2/78 (2%) Query: 344 RRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIM 403 +L W L+ IG + + P + G + + + I + Sbjct: 76 NQLLYWALTTIGFQTTMLGGYFYIPPVNKYSTGMVHLLLQVTI--DGRNYIVDAGSGSSS 133 Query: 404 QVWQMAENVYNDEEPEIP 421 Q+WQ E + ++P++P Sbjct: 134 QMWQPLELISGKDQPQVP 151 >6FYY-p nrPDB Length = 763 Score = 31.3 bits (69), Expect = 0.79, Method: Composition-based stats. Identities = 17/106 (16%), Positives = 43/106 (40%), Gaps = 11/106 (10%) Query: 321 KDEIFQVQWSPHNETILASS-----GTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHG 375 K V WSP ++ + L +D+ GE+ ++ + H Sbjct: 546 KTFANTVSWSPAGRFVVVGALVGPNMRRSDLQFYDMDYPGEKNINDNNDVSASLKDVAHP 605 Query: 376 GHTAKISDFSWNPNEPWIIC-SVSEDNIM----QVWQMAENVYNDE 416 ++A + +W+P+ ++ S S + + +++ +A N+ ++ Sbjct: 606 TYSAATN-ITWDPSGRYVTAWSSSLKHKVEHGYKIFNIAGNLVKED 650 >5BPT-A nrPDB Length = 741 Score = 31.3 bits (69), Expect = 0.86, Method: Composition-based stats. Identities = 27/75 (36%), Positives = 35/75 (46%), Gaps = 15/75 (20%) Query: 257 MIWDTR-NNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSAD-KTVALWDLRNLKLKL 314 +W N NT K EV CL++ P + ILA G AD K V L D+ + L Sbjct: 47 RVWSLPPNENTGK----------EVTCLAWRPDGK-ILAFGLADTKKVILCDVEKPE-SL 94 Query: 315 HSFESHKDEIFQVQW 329 HSF + I +QW Sbjct: 95 HSFSL-ETPISCMQW 108 Score = 29.0 bits (63), Expect = 4.0, Method: Composition-based stats. Identities = 15/104 (14%), Positives = 37/104 (35%), Gaps = 9/104 (8%) Query: 182 KEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHL 241 E L+W+P + + + + L + + + +N V +AW Sbjct: 14 HEIIFLAWSPKRD-LIALVNKAGEVLLHRLANIQRVWSLPPNENT----GKEVTCLAWRP 68 Query: 242 LHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSF 285 + L +AD +K+++ D + ++C+ + Sbjct: 69 DGKILAFGLADTKKVILCDVEKPESLHSFSL----ETPISCMQW 108 >3LED-A nrPDB Length = 392 Score = 31.3 bits (69), Expect = 0.87, Method: Composition-based stats. Identities = 20/109 (18%), Positives = 44/109 (40%), Gaps = 9/109 (8%) Query: 14 DAVEERVINEEYKIWKKNTPFLYDLVMTHALEWP----SLTAQWLPDVTKQDGKDYSVHR 69 D ++ + + K++K+ P + ++++ HA E L WL + + R Sbjct: 272 DKADKLFVQQGRKVFKEVVPLVSEMIIEHAREIGIDPHGLKRMWLHQAN--INMNEIIGR 329 Query: 70 LILGTHTSDEQNHLLI---ASVQLPSEDAQFDGSHYDNEKGEFGGFGSV 115 +LG + ++N +++ A+ F D +G+ G S Sbjct: 330 KVLGRDPTRDENVIILDDYANTSSAGSIIAFHKHQDDMAQGDLGLICSF 378 >4MDV-A nrPDB Length = 375 Score = 30.9 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 15/35 (42%), Positives = 24/35 (68%), Gaps = 1/35 (2%) Query: 39 VMTHALEWPSLTAQWLPDVTKQDG-KDYSVHRLIL 72 V+ +A++ PSL A+WL D G KDY++ RL++ Sbjct: 283 VLRYAIDRPSLIAEWLHDSMAGLGTKDYALMRLLI 317 >4U1F-A nrPDB Length = 497 Score = 30.5 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 17/106 (16%), Positives = 43/106 (40%), Gaps = 11/106 (10%) Query: 321 KDEIFQVQWSPHNETILASS-----GTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHG 375 K V WSP ++ + L +D+ GE+ ++ + H Sbjct: 378 KTFANTVSWSPAGRFVVVGALVGPNMRRSDLQFYDMDYPGEKNINDNNDVSASLKDVAHP 437 Query: 376 GHTAKISDFSWNPNEPWIIC-SVSEDNIM----QVWQMAENVYNDE 416 ++A + +W+P+ ++ S S + + +++ +A N+ ++ Sbjct: 438 TYSAATN-ITWDPSGRYVTAWSSSLKHKVEHGYKIFNIAGNLVKED 482 >2IJA-A nrPDB Length = 295 Score = 30.5 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 13/73 (17%), Positives = 24/73 (32%), Gaps = 2/73 (2%) Query: 349 WDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408 W L+ IG E + G + + + I Q+WQ Sbjct: 82 WALTTIGFETTMLGGYVYSTPAKKYSTGMIHLLLQVTI--DGRNYIVDAGSGRSYQMWQP 139 Query: 409 AENVYNDEEPEIP 421 E + ++P++P Sbjct: 140 LELISGKDQPQVP 152 >3LV4-A nrPDB Length = 456 Score = 30.1 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 28/169 (16%), Positives = 54/169 (31%), Gaps = 11/169 (6%) Query: 32 TPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRLILGTHTSDEQNHLLIASVQLP 91 P +Y+ + EW W PDVT+ + + ++ + L +A Sbjct: 57 IPNVYEELKET-FEWAESDTLWAPDVTQLEDGKFYMYYNACRGDSPRSALGLAVA----- 110 Query: 92 SEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACV-IATKTPS 150 +G + + G + H V+ + QN + + + S Sbjct: 111 ---DDIEGPYKNKGIFLKSGMDGISNDGTPYDATKHPNVVDPHTFFDQNGKLWMVYGSYS 167 Query: 151 SDVLVFDYTKHPSKPEPSGECQPDLRLRGHQK-EGYGLSWNPNLNGYLL 198 + + + K P P L H + EG + ++P Y L Sbjct: 168 GGIFILEMDKKTGFPLPGQGYGKKLIGGNHSRIEGAYILYHPETQYYYL 216 >1OI2-A nrPDB Length = 366 Score = 29.8 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 20/118 (16%), Positives = 41/118 (34%), Gaps = 12/118 (10%) Query: 193 LNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTG--HTAVVEDVAWHLLHESLFGSV 250 + L++ S T+ WD + + + +G A+V ++ L E Sbjct: 249 FDTLLVNGSYHRTLRFWDYQQGSWQEEQQTKQPLQSGDRVIALVNNLGATPLSELY---- 304 Query: 251 ADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 308 +++ + T++ + C S + I D+T+ALWD Sbjct: 305 ------GVYNRLTTRCQQAGLTIERNLIGAYCTSLDMTGFSITLLKVDDETLALWDAP 356 >4MOC-A nrPDB Length = 332 Score = 29.4 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 17/65 (26%), Positives = 26/65 (40%), Gaps = 3/65 (4%) Query: 89 QLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIE--IEIKINHEGEVNRARYMPQNACVIAT 146 L E ++FD +D E+G G+ IE + NH G + M +AT Sbjct: 152 NLMKESSKFDDLIFDEEEGAVSTRGTSVQSIELVLPPHANHHGNTFGGQIMAW-METVAT 210 Query: 147 KTPSS 151 + S Sbjct: 211 ISASR 215 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.124 0.351 Lambda K H 0.267 0.0382 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,064,155 Number of Sequences: 36641 Number of extensions: 681422 Number of successful extensions: 5932 Number of sequences better than 10.0: 164 Number of HSP's better than 10.0 without gapping: 192 Number of HSP's successfully gapped in prelim test: 101 Number of HSP's that attempted gapping in prelim test: 1362 Number of HSP's gapped (non-prelim): 1061 length of query: 430 length of database: 10,336,785 effective HSP length: 100 effective length of query: 330 effective length of database: 6,672,685 effective search space: 2201986050 effective search space used: 2201986050 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.7 bits) S2: 60 (27.8 bits)