BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q16647 (500 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2IAG-A nrPDB 979 0.0 3B98-A nrPDB 447 e-126 3SN5-A nrPDB 264 6e-71 2WX2-A nrPDB 80 3e-15 6AYB-A nrPDB 78 8e-15 3L4D-A nrPDB 71 1e-12 2X2N-A nrPDB 70 2e-12 3JUS-A nrPDB 62 8e-10 4WMZ-A nrPDB 60 3e-09 5JLC-A nrPDB 60 3e-09 2W0A-A nrPDB 58 1e-08 6CR2-A nrPDB 56 4e-08 3K9V-A nrPDB 52 5e-07 4KPA-A nrPDB 52 6e-07 4R20-A nrPDB 52 8e-07 4R1Z-A nrPDB 49 4e-06 2PG7-A nrPDB 49 4e-06 5YLW-A nrPDB 49 5e-06 6B82-A nrPDB 49 5e-06 2VE3-A nrPDB 49 7e-06 5FSA-A nrPDB 48 9e-06 6M7X-A nrPDB 48 1e-05 5E0E-A nrPDB 47 2e-05 2HI4-A nrPDB 45 9e-05 4ZGX-A nrPDB 44 1e-04 5VEU-A nrPDB 44 2e-04 5E58-A nrPDB 43 3e-04 6DWN-A nrPDB 43 4e-04 5W0C-A nrPDB 42 4e-04 1N6B-A nrPDB 42 5e-04 4GQS-A nrPDB 42 6e-04 6C94-A nrPDB 42 6e-04 6DA2-A nrPDB 42 7e-04 3EL3-A nrPDB 42 7e-04 3E6I-A nrPDB 42 7e-04 6IQ5-A nrPDB 39 0.004 3EJB-B nrPDB 39 0.004 2NNH-A nrPDB 39 0.004 5UYS-A nrPDB 39 0.005 4H1N-A nrPDB 39 0.005 1CPT-A nrPDB 38 0.008 5VBU-A nrPDB 38 0.012 3DL9-A nrPDB 38 0.012 3QZ1-A nrPDB 37 0.013 3NC3-A nrPDB 37 0.016 3N9Z-A nrPDB 35 0.057 3MDV-A nrPDB 33 0.26 6FYJ-A nrPDB 33 0.29 5EX6-C nrPDB 32 0.53 6G71-A nrPDB 32 0.70 4WPZ-A nrPDB 31 0.99 1WIY-A nrPDB 31 1.0 5DE9-A nrPDB 31 1.1 3S79-A nrPDB 31 1.2 4IAO-A nrPDB 31 1.2 2HJH-A nrPDB 31 1.4 6A0P-A nrPDB 30 1.8 6B11-A nrPDB 30 1.9 2NZA-A nrPDB 30 2.0 4XE3-A nrPDB 30 2.3 2WIY-A nrPDB 30 2.5 5L94-A nrPDB 30 2.9 3IBD-A nrPDB 30 3.5 1GAN-A nrPDB 29 4.9 2Z36-A nrPDB 28 6.2 2RCM-A nrPDB 28 7.0 2XWE-A nrPDB 28 8.4 4TX3-A nrPDB 28 8.9 6FSH-A nrPDB 28 9.0 >2IAG-A nrPDB Length = 482 Score = 979 bits (2532), Expect = 0.0, Method: Compositional matrix adjust. Identities = 478/478 (100%), Positives = 478/478 (100%) Query: 23 RTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHS 82 RTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHS Sbjct: 1 RTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHS 60 Query: 83 YDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYT 142 YDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYT Sbjct: 61 YDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYT 120 Query: 143 NLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSAD 202 NLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSAD Sbjct: 121 NLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSAD 180 Query: 203 VFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLH 262 VFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLH Sbjct: 181 VFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLH 240 Query: 263 LEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQ 322 LEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQ Sbjct: 241 LEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQ 300 Query: 323 PVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDR 382 PVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDR Sbjct: 301 PVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDR 360 Query: 383 LLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCL 442 LLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCL Sbjct: 361 LLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCL 420 Query: 443 GRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP 500 GRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP Sbjct: 421 GRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP 478 >3B98-A nrPDB Length = 475 Score = 447 bits (1149), Expect = e-126, Method: Compositional matrix adjust. Identities = 228/485 (47%), Positives = 320/485 (65%), Gaps = 25/485 (5%) Query: 18 LLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVL 77 +L RRTRR EPPLD G IPWLG+AL+FGKDAA FLTRMKEKHGDIFT+ G Y+TVL Sbjct: 8 VLYGRRTRRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVL 67 Query: 78 LDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALT 137 LD + YDAV+ + + LD +YA LM+RIF++ LP ++P EK R ++ L L+ Sbjct: 68 LDSNCYDAVLSDVAS-LDQTSYAQVLMKRIFNMILPSHNPESEKKRAEMHFQGASLTQLS 126 Query: 138 EAMYTNLHAVLLGDATEAG---SGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQA 194 +M NL LL +E G S W + GL + YS L + GYLT++G E Sbjct: 127 NSMQNNLR--LLMTPSEMGLKTSEWKKDGLFNLCYSLLFKTGYLTVFGAEN--------- 175 Query: 195 QDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSK 254 + ++ FR+ D+LLPKLAR +++ +K + + +LWK L+P+ L R+ Sbjct: 176 NNSAALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASAAREKLWKWLTPSGLDRKPREQS 235 Query: 255 WLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELE 314 WL SY+ L++ G+ EMQ RA++LQLW TQGN GPAAFW++ +LL +PEAL AVR E++ Sbjct: 236 WLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQ 295 Query: 315 SILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGRE 374 + L ++ +TPV DSVL E+LRLTAA ITR+V D + +++G+E Sbjct: 296 G---------GKHLRLEERQ-KNTPVFDSVLWETLRLTAAALITRDVTQDKKICLSNGQE 345 Query: 375 FNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPW 434 ++LRRGDRL +FPF+SPQ DP+I+ PE+F+++RFLN D +EKKDF+K+G R+K ++PW Sbjct: 346 YHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVKYPSVPW 405 Query: 435 GAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPV 494 G N C GR +AV++IK+ VF +L D+EL + + +P D SRYGFG++QP D+ + Sbjct: 406 GTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDLEI 465 Query: 495 RYRIR 499 RYRIR Sbjct: 466 RYRIR 470 >3SN5-A nrPDB Length = 491 Score = 264 bits (675), Expect = 6e-71, Method: Compositional matrix adjust. Identities = 161/490 (32%), Positives = 256/490 (52%), Gaps = 19/490 (3%) Query: 20 SRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLD 79 + R R+ GEPPL+ G IP+LG AL FG + FL + KHG +FT + G+YV + + Sbjct: 5 TSSRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITN 64 Query: 80 PHSYDAVVWEPR----TRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQA 135 P SY V+ + + F A R D + + + +K TL L + Sbjct: 65 PLSYHKVLCHGKYFDWKKFHFALSAKAFGHRSIDPMDGNTTENINDTFIK-TLQGHALNS 123 Query: 136 LTEAMYTNLHAVLLG--DATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQ 193 LTE+M NL ++ + + W G+ F Y + AGYLT++G + R + Sbjct: 124 LTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQ-- 181 Query: 194 AQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRS 253 + H + F+Q D++ P L G L + + + +L + L L +R S Sbjct: 182 ---KAHILNNLDNFKQFDKVFPALVAG-LPIHMFRTAHNAREKLAESLRHENLQKRESIS 237 Query: 254 KWLESYLLHLEEMGVSEEMQ-ARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGE 312 + + + + + ++++ A+ ++ LWA+Q N PA FW L +++NPEA+ A E Sbjct: 238 ELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEE 297 Query: 313 LESILWQAEQPVS---QTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPM 369 ++ L A Q VS L Q L+ PVLDS++ ESLRL++A R D + + Sbjct: 298 VKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHL 357 Query: 370 ADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKN 429 DG +N+R+ D + L+P L DPEIY DP FKY+R+L+ +G K FY +G +LK Sbjct: 358 EDG-SYNIRKDDIIALYPQLM-HLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKY 415 Query: 430 YNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPE 489 Y MP+G+G C GR +A++ IKQF+ L+L + +LELI + P D SR G G++ P Sbjct: 416 YYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPL 475 Query: 490 HDVPVRYRIR 499 +D+ +Y+ + Sbjct: 476 NDIEFKYKFK 485 >2WX2-A nrPDB Length = 473 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 115/494 (23%), Positives = 197/494 (39%), Gaps = 81/494 (16%) Query: 24 TRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK-HGDIFTILVGGRYVTVLLDPHS 82 T RP +PP+ ++P+LG+ + FGK+ F+ R K +FTI +GG+ VT++ DPH Sbjct: 12 TTRPTDPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHE 71 Query: 83 YDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYT 142 + + + PR + +M +F + + +P + R +L L E LT A + Sbjct: 72 H-SRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPY-PRMREQLNFLAEE---LTIAKFQ 126 Query: 143 NLHAVLLGDATE-AGSGWHE----MGLLDFSYSFLLRAGYLTLYGIEALPR---THESQA 194 N + + + W E + LL+ + ++ L+G + R H +Q Sbjct: 127 NFVPAIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQL 186 Query: 195 QDRVHS----ADVFHTFRQLDRL-LPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARR 249 ++ S A VF + L RL LP+ AR ++ L K+L +AR Sbjct: 187 LSKMESSLIPAAVFMPW--LLRLPLPQSARCR----------EARAELQKILGEIIVARE 234 Query: 250 A-------HRSKWLESYLLHLEEMGVSEEMQARA--LVLQLWATQGNMGPAAFWLLLFLL 300 + S L L + G + +V ++A Q W +L L+ Sbjct: 235 KEEASKDNNTSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLM 294 Query: 301 --KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLR-----LTA 353 KN + L + E++ Q V+D P + + ES+R L Sbjct: 295 HPKNKKWLDKLHKEIDEFPAQLNY---------DNVMDEMPFAERCVRESIRRDPPLLMV 345 Query: 354 APFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPD 413 + EV V + + +GD + P LS + D E F R +P+ Sbjct: 346 MRMVKAEVKVG---------SYVVPKGDIIACSPLLS-------HHDEEAFPNPRLWDPE 389 Query: 414 GSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEI 473 EK D G +GAG + C+G+ +A+ +K + D +L+ +V Sbjct: 390 RDEKVDGAFIG---------FGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPD 440 Query: 474 PEFDLSRYGFGLMQ 487 P++ G L Q Sbjct: 441 PDYHTMVVGPTLNQ 454 >6AYB-A nrPDB Length = 466 Score = 78.2 bits (191), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 98/496 (19%), Positives = 203/496 (40%), Gaps = 54/496 (10%) Query: 19 LSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLL 78 ++++ + + PP IP++G + F K+ F+ +K+GD+FT + G+ +T L Sbjct: 1 MAKKTSSKGKLPPRVPNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFLN 60 Query: 79 DPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTE 138 P D L F M +F + + + S E+ ++ + L Sbjct: 61 HPKILDTFFKATDNELSLRDVYRF-MRPVFGTGVVYDADSTERMMEQVKFVSSGLTTARF 119 Query: 139 AMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRV 198 ++ ++ + + + + + ++ L G E E Sbjct: 120 RVFVDIFEDEIAHKVKELGPEGTVDVAELMADLIIFTASRCLLGDEVRQYLSEKNLGKLY 179 Query: 199 HSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLES 258 H D+ L P L K +V +LL R + H + L+ Sbjct: 180 H--DIDDGISPLSFFYPSLPAPKRDKARK----AVGEIFQELLDKRREEHKKHPERLLDE 233 Query: 259 YLLHLEEMGVSEEMQ----------ARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAA 308 + + + ++++ + L+ L+A Q + W L+ ++ N + L Sbjct: 234 SKMDVVDHLLTQKYKDGQELTDVHRIGILIAGLFAGQHTSSITSSWTLMNVISNKKVLEK 293 Query: 309 VRGELESILWQAEQPVSQTTTLPQKVLDSTPV-----LDSVLSESLRLTAAPFITREVVV 363 VR E E I+ KVLD V L++ + E+LR+ P I +++ Sbjct: 294 VRKEQEEIMGS------------DKVLDYDKVMKMDYLEACMKEALRM-YPPLI---MIM 337 Query: 364 DLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKD 423 +A + ++ + +G+ L++ P ++ R + YT+P+VF R +E+K+ Sbjct: 338 RMARKPRECEQYIIPKGNILVVSPSVA-GRCTDTYTNPDVFDPERL-----TERKEH--- 388 Query: 424 GKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGF 483 ++ K +P+GAG + C+G ++A+ +K + ++L + D+E I +IP+ Y Sbjct: 389 -EKFKYGAVPFGAGRHKCIGENFALLQVKSIISILLRYFDMEYIG---KIPD---PSYTS 441 Query: 484 GLMQPEHDVPVRYRIR 499 ++ P +RY++R Sbjct: 442 LVVGPSPPTRMRYKLR 457 >3L4D-A nrPDB Length = 453 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 100/455 (21%), Positives = 185/455 (40%), Gaps = 55/455 (12%) Query: 30 PPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWE 89 PP+ G+ P++G+ + FGKD F+ + K+K+G IFT+ + G +TV+ D H + + Sbjct: 5 PPVVHGTTPFVGHIIQFGKDPLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQHSK-FFT 63 Query: 90 PRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLL 149 PR + M +F + + +P + R +L L E LT A + N + Sbjct: 64 PRNEILSPREVYSFMVPVFGEGVAYAAPY-PRMREQLNFLAEE---LTVAKFQNFAPSIQ 119 Query: 150 GDATE-AGSGWH----EMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVF 204 + + + W+ E+ +LD + ++ L+G + R Q + A + Sbjct: 120 HEVRKFMKANWNKDEGEINILDDCSAMIINTACQCLFGEDLRKRLDARQFAQLL--AKME 177 Query: 205 HTFRQLDRLLPKLARGSLSVGDKDHMC-SVKSRLWKLLSPARLARR-------AHRSKWL 256 LP + + L + + C ++ L +LS +AR + S L Sbjct: 178 SCLIPAAVFLPWILKLPLP---QSYRCRDARAELQDILSEIIIAREKEEAQKDTNTSDLL 234 Query: 257 ESYL--LHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL--KNPEALAAVRGE 312 L ++ + +S+ +V ++A Q W LL L+ +N LA + E Sbjct: 235 AGLLGAVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQE 294 Query: 313 LESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADG 372 ++ Q V++ P + ES+R P + ++ + P+ G Sbjct: 295 IDEFPAQLNY---------DNVMEEMPFAEQCARESIR-RDPPLVM--LMRKVLKPVQVG 342 Query: 373 REFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNM 432 + + + GD + P LS Q D E F R NP+ ++ K + Sbjct: 343 K-YVVPEGDIIACSPLLSHQ-------DEEAFPNPREWNPE--------RNMKLVDGAFC 386 Query: 433 PWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELI 467 +GAG + C+G + + +K + VL D EL+ Sbjct: 387 GFGAGVHKCIGEKFGLLQVKTVLATVLRDYDFELL 421 >2X2N-A nrPDB Length = 475 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 103/481 (21%), Positives = 188/481 (39%), Gaps = 81/481 (16%) Query: 26 RPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK-HGDIFTILVGGRYVTVLLDPHSYD 84 RP +PP+ ++P LG+ + FGK F+ K + IFTI + G+ VT++ DPH + Sbjct: 14 RPTDPPVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEH- 72 Query: 85 AVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNL 144 + + PR + M +F + + +P + R +L L E LT A + N Sbjct: 73 SRFFLPRNEVLSPREVYSFMVPVFGEGVAYAAPY-PRMREQLNFLAEE---LTIAKFQNF 128 Query: 145 HAVLLGDATE-AGSGWH----EMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVH 199 + + + + W E+ LL+ + ++ L+G +D Sbjct: 129 VPAIQHEVRKFMAANWDKDEGEINLLEDCSTMIINTACQCLFG------------EDLRK 176 Query: 200 SADVFHTFRQLDRLLPKLARGSLSVG-----------DKDHMC-SVKSRLWKLLSPARLA 247 D R+ +LL K+ + + C ++ L K+LS +A Sbjct: 177 RLDA----RRFAQLLAKMESSLIPAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIA 232 Query: 248 RRA-------HRSKWLESYLLHLEEMGVSEEMQARA--LVLQLWATQGNMGPAAFWLLLF 298 R+A S L L + G + +V ++A Q W +L Sbjct: 233 RKAAAVNKDSSTSDLLSGLLSAVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLH 292 Query: 299 LL--KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPF 356 L+ N + L A+R E+E Q V+D P + ES+R Sbjct: 293 LMHPANVKHLEALRKEIEEFPAQLNY---------NNVMDEMPFAERCARESIRRDPPLL 343 Query: 357 -ITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGS 415 + R+V+ D+ + + + +GD + P LS + D E F R +P+ Sbjct: 344 MLMRKVMADVKV-----GSYVVPKGDIIACSPLLS-------HHDEEAFPEPRRWDPERD 391 Query: 416 EKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPE 475 EK ++ + +GAG + C+G+ + + +K + D +L+ +V P+ Sbjct: 392 EK---------VEGAFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQLLRDEVPDPD 442 Query: 476 F 476 + Sbjct: 443 Y 443 >3JUS-A nrPDB Length = 461 Score = 61.6 bits (148), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 109/485 (22%), Positives = 203/485 (41%), Gaps = 59/485 (12%) Query: 30 PPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWE 89 PP IP+LG+A+ FGK FL EK+G +F+ + G+ T LL + A+++ Sbjct: 13 PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDA-AALLFN 71 Query: 90 PRTRLDFHAYAIF--LMERIFDVQLPHYSPS----DEKARMKLTLLHRELQALTEAMYTN 143 + D +A ++ L +F + + P+ ++K +K L A + Sbjct: 72 SKNE-DLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLK--------SGLNIAHFKQ 122 Query: 144 LHAVLLGDATEAGSGWHEMGLLD----FSYSFLLRAGYLTLYGIEALPRTHESQAQDRVH 199 +++ + E W E G + S +L A + L+G E + +E AQ Sbjct: 123 HVSIIEKETKEYFESWGESGEKNVFEALSELIILTASH-CLHGKEIRSQLNEKVAQ---L 178 Query: 200 SADVFHTFRQLDRLLPK-LARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLES 258 AD+ F LLP L S D+ H +K +K + R ++ L++ Sbjct: 179 YADLDGGFSHAAWLLPGWLPLPSFRRRDRAHR-EIKDIFYKAIQKRRQSQE-KIDDILQT 236 Query: 259 YLLHLEEMG--VSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESI 316 L + G ++++ A L+ L A Q + W+ FL ++ E +++ Sbjct: 237 LLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTV 296 Query: 317 LWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFN 376 + P++ L +LD + E+LRL P + +++ +A + Sbjct: 297 CGENLPPLTYDQ------LKDLNLLDRCIKETLRLR-PPIM---IMMRMARTPQTVAGYT 346 Query: 377 LRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFL--NPDGSEKKDFYKDGKRLKNYNMPW 434 + G ++ + P ++ QR + + + F +R+L NP EK + +P+ Sbjct: 347 IPPGHQVCVSPTVN-QRLKDSWVERLDFNPDRYLQDNPASGEKFAY-----------VPF 394 Query: 435 GAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPV 494 GAG + C+G ++A IK +L + +LI+ F Y + PE+ V + Sbjct: 395 GAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDG-----YFPTVNYTTMIHTPENPV-I 448 Query: 495 RYRIR 499 RY+ R Sbjct: 449 RYKRR 453 >4WMZ-A nrPDB Length = 539 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 95/452 (21%), Positives = 183/452 (40%), Gaps = 43/452 (9%) Query: 17 LLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTV 76 LL S R+ R PPL IPW+G A+ +G F ++K+GDIF+ ++ GR +TV Sbjct: 47 LLYSLRKDR----PPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTV 102 Query: 77 LLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPS----DEKARMKLTLLHRE 132 L P ++ V + A L +F + + P+ ++K +K L Sbjct: 103 YLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEA 162 Query: 133 LQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHES 192 ++ + ++ D+ G +D ++ +T++ E Sbjct: 163 FKSYVPLIAEEVYKYFR-DSKNFRLNERTTGTID----VMVTQPEMTIFTASRSLLGKEM 217 Query: 193 QAQDRVHSA----DVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLAR 248 +A+ A D+ F ++ + P L +DH S + L R Sbjct: 218 RAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYR--KRDHAQKAISGTYMSLIKERRKN 275 Query: 249 RAHRSKWLESYLL----HLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPE 304 + + L L+ + + + ++++ A L+ L Q + W+LL L + P+ Sbjct: 276 NDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPD 335 Query: 305 ALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPF--ITREVV 362 + E +L ++ L +L P+L+ + E+LR+ P + R+V+ Sbjct: 336 VQQELYEEQMRVLDGGKK------ELTYDLLQEMPLLNQTIKETLRM-HHPLHSLFRKVM 388 Query: 363 VDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGS-----EK 417 D+ +P + + G +L+ P + RD E + + F +R+ N S E+ Sbjct: 389 KDMHVP---NTSYVIPAGYHVLVSPGYTHLRD-EYFPNAHQFNIHRWNNDSASSYSVGEE 444 Query: 418 KD--FYKDGKRLKNYNMPWGAGHNHCLGRSYA 447 D F K + + +P+G G + C+G +A Sbjct: 445 VDYGFGAISKGVSSPYLPFGGGRHRCIGEHFA 476 >5JLC-A nrPDB Length = 515 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 100/468 (21%), Positives = 189/468 (40%), Gaps = 74/468 (15%) Query: 17 LLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTV 76 LL S R+ R PPL IPW+G A+ +G F ++K+GDIF+ ++ GR +TV Sbjct: 29 LLYSLRKDR----PPLVFYWIPWVGSAIPYGTKPYEFFEDCQKKYGDIFSFMLLGRIMTV 84 Query: 77 LLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFD----VQLPHYSPSDEKARMKLTLLH-- 130 L P ++ + + A L +F P++ ++K +K L Sbjct: 85 YLGPKGHEFIFNAKLADVSAEAAYSHLTTPVFGKGVIYDCPNHRLMEQKKFVKGALTKEA 144 Query: 131 --RELQALTEAMYTNLHAVLLGDATEAGSG-------WHEMGLLDFSYSFLLRAGYLTLY 181 R + + E +Y E SG EM + S S L + Sbjct: 145 FVRYVPLIAEEIYKYFRNSKNFKINENNSGIVDVMVSQPEMTIFTASRSLLGK------- 197 Query: 182 GIEALPRTHESQAQDRVHS------ADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKS 235 + +D++ + +D+ F ++ + P L +DH S Sbjct: 198 -----------EMRDKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYR--KRDHAQQAIS 244 Query: 236 RLWKLLSPARLARRAHRSKWLESYLL----HLEEMGVSEEMQARALVLQLWATQGNMGPA 291 + L R + +++ L L+ + + ++++ A L+ L Q Sbjct: 245 GTYMSLIKERREKNDIQNRDLIDELMKNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAAT 304 Query: 292 AFWLLLFLLKNPEALAAVRGELESILWQAEQPV--SQTTTLPQKVLDSTPVLDSVLSESL 349 + W LL L + P +++ L+Q + V + T L L + P+L+ ++ E+L Sbjct: 305 SAWCLLHLAERP--------DVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETL 356 Query: 350 RLTAAPF--ITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYN 407 RL P + R+V+ D+A+P + + R +L+ P + ++ E + P F + Sbjct: 357 RL-HHPLHSLFRKVMRDVAIP---NTSYVVPRDYHVLVSPGYTHLQE-EFFPKPNEFNIH 411 Query: 408 RF------LNPDGSEKKD--FYKDGKRLKNYNMPWGAGHNHCLGRSYA 447 R+ + G ++ D F K + + +P+G G + C+G +A Sbjct: 412 RWDGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFA 459 >2W0A-A nrPDB Length = 455 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 111/474 (23%), Positives = 187/474 (39%), Gaps = 57/474 (12%) Query: 41 GYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYA 100 G+ +F D + R++++ GD+ T + G+ V +L H+ + LD A A Sbjct: 17 GHLEEFRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLD-QAKA 75 Query: 101 IFLMERIF-DVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGW 159 M IF + + SP K + L E A + ++ D EAG Sbjct: 76 YPFMTPIFGEAVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQVRRMIADWGEAG--- 132 Query: 160 HEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQ----LDRLLP 215 E+ LLDF + L G + Q R A ++H + L + P Sbjct: 133 -EIDLLDFFAELTIYTSSACLIG-----KKFRDQLDGRF--AKLYHELERGTDPLAYVDP 184 Query: 216 KLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAH------RSKWLESYLLHLEEMGV- 268 L S D+ ++ L L++ R A+ L+ + E G Sbjct: 185 YLPIESFRRRDE-----ARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTP 239 Query: 269 --SEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQ 326 S + + ++A A W L+ L+++ +A AAV EL+ + Sbjct: 240 RFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGR----- 294 Query: 327 TTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLF 386 ++ L P L++VL E+LRL P I +++ +A + + + GD + Sbjct: 295 --SVSFHALRQIPQLENVLKETLRLHP-PLI---ILMRVAKGEFEVQGHRIHEGDLVAAS 348 Query: 387 PFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYN-MPWGAGHNHCLGRS 445 P +S R PE + DP F R+ P ++D L + +P+GAG + C+G + Sbjct: 349 PAIS-NRIPEDFPDPHDFVPARYEQP---RQEDL------LNRWTWIPFGAGRHRCVGAA 398 Query: 446 YAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 499 +A+ IK ++L + E+ E D S+ L QP VRYR R Sbjct: 399 FAIMQIKAIFSVLLREYEFEMAQPP-ESYRNDHSKMVVQLAQP---AAVRYRRR 448 >6CR2-A nrPDB Length = 477 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 89/447 (19%), Positives = 168/447 (37%), Gaps = 58/447 (12%) Query: 30 PPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAV--- 86 PP+ P++G + +G D F + K+GDIFT ++ G+ TV L D + Sbjct: 6 PPVVFHWFPFIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGNDFILNG 65 Query: 87 ---------VWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALT 137 V+ P T F + ++ P+ ++K +K L L++ Sbjct: 66 KLRDVCAEEVYSPLTTPVFGRHVVY--------DCPNAKLMEQKKFVKYGLTSDALRSYV 117 Query: 138 EAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDR 197 + + + + G G+ D + +T+Y + E +++ Sbjct: 118 PLITDEVESFVKNSPAFQG----HKGVFDVCKTI----AEITIYTASRSLQGKEVRSKFD 169 Query: 198 VHSADVFHT----FRQLDRLLP--KLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAH 251 A+++H F ++ +LP L + + + K A + + Sbjct: 170 STFAELYHNLDMGFAPINFMLPWAPLPHNRKRDAAQRKLTETYMEIIKARRQAGSKKDSE 229 Query: 252 RSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRG 311 W ++ V +E A ++ L A Q + A W++L L P+ + + Sbjct: 230 DMVWNLMSCVYKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQ 289 Query: 312 ELESILWQAEQPVSQTTTLPQKVLDSTPVLD---SVLSESLRLTAAPFITREVVVDLAMP 368 E +L + LP D+ LD V+ E+LRL A ++ + P Sbjct: 290 EQIRVL---------GSDLPPLTYDNLQKLDLHAKVIKETLRLHAP---IHSIIRAVKNP 337 Query: 369 MA-DGREFNLRRGDRLLLFPFLSPQRDPEIYT----DPEVFKYNRFLNPDGSEKKDFYKD 423 MA DG + + +L P ++ + + +P + N + + EK D Y Sbjct: 338 MAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVD-YGY 396 Query: 424 GKRLKNYN---MPWGAGHNHCLGRSYA 447 G K N +P+GAG + C+G +A Sbjct: 397 GLVSKGTNSPYLPFGAGRHRCIGEQFA 423 >3K9V-A nrPDB Length = 482 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 61/233 (26%), Positives = 102/233 (43%), Gaps = 33/233 (14%) Query: 269 SEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTT 328 +E+ A LQL A + + W+L L +NP+A + E++S+L + P ++ Sbjct: 281 KKELYAAVTELQLAAVETTAN-SLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED- 338 Query: 329 TLPQKVLDSTPVLDSVLSESLRLT-AAPFITREVVVDLAMPMADGREFNLRRGDRLLL-F 386 L + P L + L ES+RLT + PF TR L P G E+ L +G L L Sbjct: 339 ------LRNMPYLKACLKESMRLTPSVPFTTR----TLDKPTVLG-EYALPKGTVLTLNT 387 Query: 387 PFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSY 446 L D + D F+ R+L K+ K ++P+G G C+GR Sbjct: 388 QVLGSSEDN--FEDSHKFRPERWLQ----------KEKKINPFAHLPFGIGKRMCIGRRL 435 Query: 447 AVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 499 A ++ + L + +++ D E E G++ P ++P+ +R R Sbjct: 436 A--ELQLHLALCWIIQKYDIVATDNEPVEM----LHLGILVPSRELPIAFRPR 482 >4KPA-A nrPDB Length = 494 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 87/207 (42%), Gaps = 32/207 (15%) Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-T 352 + L FL+KNP L E +L Q L + VL+E+LRL Sbjct: 299 FALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLK--------YVGMVLNEALRLWP 350 Query: 353 AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQ--RDPEIYTDP-EVFKYNRF 409 AP + D + G E+ L +GD L++ L PQ RD I+ D E F+ RF Sbjct: 351 TAPAFSLYAKEDTVL----GGEYPLEKGDELMV---LIPQLHRDKTIWGDDVEEFRPERF 403 Query: 410 LNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLE-LIN 468 NP + F P+G G C+G+ +A++ + ++L H D E N Sbjct: 404 ENPSAIPQHAF-----------KPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTN 452 Query: 469 ADVEIPE-FDLSRYGFGLMQPEHDVPV 494 +++I E L GF + +P+ Sbjct: 453 YELDIKETLTLKPEGFVVKAKSKKIPL 479 >4R20-A nrPDB Length = 486 Score = 51.6 bits (122), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 51/197 (25%), Positives = 87/197 (44%), Gaps = 23/197 (11%) Query: 293 FWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLT 352 W + FLL +P+ V+ EL+ + P + P P+LD+VL E +R+ Sbjct: 297 LWTIAFLLHHPQLQERVQAELDECVGVDRPPC--LSDRPH-----LPLLDAVLCEVMRIR 349 Query: 353 AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNP 412 I ++ +AM ++ +G R+L+ + DP+ + PE F RFL P Sbjct: 350 PVSPI---LIPHVAMQDTSLGGHSVPKGTRVLVN-MWAIHHDPKHWDQPEQFNPERFLEP 405 Query: 413 DGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVE 472 G K+ ++ +P+GAG C+G S A + FV L ++ Sbjct: 406 SGK---------KKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFS-CPSEAS 455 Query: 473 IPEFDLSRYGFGLMQPE 489 +P+ R+G ++QPE Sbjct: 456 LPDLQ-GRFGV-VLQPE 470 >4R1Z-A nrPDB Length = 439 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 45/176 (25%), Positives = 84/176 (47%), Gaps = 24/176 (13%) Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQP-VSQTTTLPQKVLDSTPVLDSVLSESLRLT 352 W + +L+ NP+ ++ EL+S + + P +S LP L++ + E LR+ Sbjct: 244 WSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLP--------YLEATIREVLRIR 295 Query: 353 -AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLN 411 +P + V A+ + E+ +++G R+++ S D + + +PE+F RFLN Sbjct: 296 PVSPLLIPHV----ALQDSSVGEYTVQKGTRVVI-NLWSLHHDKKEWKNPELFDPGRFLN 350 Query: 412 PDGSEKKDFYKDGKRLKNYN-MPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLEL 466 +G DG + + +P+GAG CLG + A + F+ +L LE+ Sbjct: 351 EEG--------DGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEM 398 >2PG7-A nrPDB Length = 476 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 55/221 (24%), Positives = 95/221 (42%), Gaps = 34/221 (15%) Query: 255 WLESYLLHL--EEMGVSEEMQARALV---LQLW-ATQGNMGPAAFWLLLFLLKNPEALAA 308 +++S+L+ + EE + E + LV LQL+ + + L L+K+PE A Sbjct: 245 FIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPEVEAK 304 Query: 309 VRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-TAAPF-ITREVVVDLA 366 V E++ ++ + QP + P +++V+ E R P + R V D Sbjct: 305 VHEEIDRVIGKNRQPKFEDRA-------KMPYMEAVIHEIQRFGDVIPMSLARRVKKDTK 357 Query: 367 MPMADGREFNLRRGDRLLLFPFL-SPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGK 425 R+F L +G + +P L S RDP +++P+ F FLN G KK Sbjct: 358 F-----RDFFLPKGTEV--YPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKS------ 404 Query: 426 RLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLEL 466 + +P+ G +C G A ++ F+F V + L Sbjct: 405 ---DAFVPFSIGKRNCFGEGLA--RMELFLFFTTVMQNFRL 440 >5YLW-A nrPDB Length = 495 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 46/172 (26%), Positives = 78/172 (45%), Gaps = 28/172 (16%) Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-T 352 W + L+ NP+ +A ++ EL+S+ ++ + + +P+ P L +V+ E +R+ Sbjct: 309 WAMSELVMNPDKMARLKAELKSV--AGDEKIVDESAMPK-----LPYLQAVIKEVMRIHP 361 Query: 353 AAPFITREVVVDLAMPMADGREFN---LRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRF 409 P + L +E N + +G ++L+ + + RDP I+TDPE F RF Sbjct: 362 PGPLL-------LPRKAESDQEVNGYLIPKGTQILINAY-AIGRDPSIWTDPETFDPERF 413 Query: 410 LNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVH 461 L+ K DF L +P+G+G C G A I LVH Sbjct: 414 LD----NKIDFKGQDYEL----LPFGSGRRVCPGMPLATR-ILHMATATLVH 456 Score = 35.0 bits (79), Expect = 0.074, Method: Compositional matrix adjust. Identities = 20/76 (26%), Positives = 34/76 (44%), Gaps = 5/76 (6%) Query: 5 ALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDI 64 A L +AA + L RRR PG P P +G L G + ++ +++G + Sbjct: 8 AALFFIAATITFLSFRRRRNLPPGPFPY-----PIVGNMLQLGANPHQVFAKLSKRYGPL 62 Query: 65 FTILVGGRYVTVLLDP 80 +I +G Y ++ P Sbjct: 63 MSIHLGSLYTVIVSSP 78 >6B82-A nrPDB Length = 509 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 44/176 (25%), Positives = 84/176 (47%), Gaps = 24/176 (13%) Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQP-VSQTTTLPQKVLDSTPVLDSVLSESLRLT 352 W + +L+ NP+ ++ EL+S + + P +S LP L++ + E +R+ Sbjct: 308 WSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLP--------YLEATICEVMRIR 359 Query: 353 -AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLN 411 +P + V A+ + E+ +++G R+++ S D + + +PE+F RFLN Sbjct: 360 PVSPLLIPHV----ALQDSSVGEYTVQKGTRVVI-NMWSLHHDEKEWKNPELFDPGRFLN 414 Query: 412 PDGSEKKDFYKDGKRLKNYN-MPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLEL 466 +G DG + + +P+GAG CLG + A + F+ +L LE+ Sbjct: 415 EEG--------DGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEM 462 >2VE3-A nrPDB Length = 444 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 43/152 (28%), Positives = 66/152 (43%), Gaps = 19/152 (12%) Query: 319 QAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL---TAAPFITREVVVDLAMPMADGREF 375 Q + + + L + L P LD VL E LRL F RE++ D + F Sbjct: 282 QEQNKLQLSQELTAETLKKMPYLDQVLQEVLRLIPPVGGGF--RELIQDCQF-----QGF 334 Query: 376 NLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWG 435 + +G L+ + DP++Y DPE F RF PDGS + ++P+G Sbjct: 335 HFPKG-WLVSYQISQTHADPDLYPDPEKFDPERF-TPDGSATHN-------PPFAHVPFG 385 Query: 436 AGHNHCLGRSYAVNSIKQFVFLVLVHLDLELI 467 G CLG+ +A +K F ++ D L+ Sbjct: 386 GGLRECLGKEFARLEMKLFATRLIQQFDWTLL 417 Score = 31.6 bits (70), Expect = 0.81, Method: Compositional matrix adjust. Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 2/48 (4%) Query: 30 PPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVL 77 PP D G +PWLG L+F D F + +++ G IF + G+ V + Sbjct: 14 PPGDFG-LPWLGETLNFLND-GDFGKKRQQQFGPIFKTRLFGKNVIFI 59 >5FSA-A nrPDB Length = 490 Score = 48.1 bits (113), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 20/57 (35%), Positives = 33/57 (57%) Query: 30 PPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAV 86 PPL IPW G A +G+ F ++K+GD+F+ ++ G+ +TV L P ++ V Sbjct: 6 PPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFV 62 Score = 34.7 bits (78), Expect = 0.087, Method: Compositional matrix adjust. Identities = 47/237 (19%), Positives = 103/237 (43%), Gaps = 24/237 (10%) Query: 256 LESYLLH---LEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGE 312 ++S L+H + + ++++ A L+ L Q + W LL L + P + E Sbjct: 235 IDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQE 294 Query: 313 LESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPF--ITREVVVDLAMPMA 370 + +L ++ L + L P +++ + E+LR+ P I R+V L +P Sbjct: 295 VVELL---KEKGGDLNDLTYEDLQKLPSVNNTIKETLRM-HMPLHSIFRKVTNPLRIPET 350 Query: 371 DGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRF---------LNPDGSEKKD-- 419 + + + +G +L+ P + + + +PE F R+ ++ + S++ D Sbjct: 351 N---YIVPKGHYVLVSPGYAHTSE-RYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYG 406 Query: 420 FYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEF 476 F K K + + +P+G G + C+G +A + + + +L + V P++ Sbjct: 407 FGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDY 463 >6M7X-A nrPDB Length = 484 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 45/165 (27%), Positives = 76/165 (46%), Gaps = 27/165 (16%) Query: 284 TQGNMGPAAFWLLLFLL---KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPV 340 T G++ F LL+ L +NP A+R E + + + PQK P+ Sbjct: 289 TAGSVDTTVFPLLMTLFELARNPNVQQALRQE-------SLAAAASISEHPQKATTELPL 341 Query: 341 LDSVLSESLRL-TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYT 399 L + L E+LRL F+ R DL + + +++ G + +F + S R+P ++ Sbjct: 342 LRAALKETLRLYPVGLFLERVASSDLVL-----QNYHIPAGTLVRVFLY-SLGRNPALFP 395 Query: 400 DPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGR 444 PE + R+L+ GS ++FY ++P+G G CLGR Sbjct: 396 RPERYNPQRWLDIRGS-GRNFY---------HVPFGFGMRQCLGR 430 >5E0E-A nrPDB Length = 463 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 59/262 (22%), Positives = 107/262 (40%), Gaps = 47/262 (17%) Query: 250 AHRSKWLESYLLHLEEMGVSE--EMQARALVLQL----WATQGNMGPAAFWLLLFLLKNP 303 +H ++++YLL +E+ ++ E + LV+ + +A + L +LK P Sbjct: 231 SHPRDFIDTYLLRMEKEKSNQHTEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYP 290 Query: 304 EALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVV 363 V+ E++ ++ P + T P ++V+ E R + ++ Sbjct: 291 HVAEKVQKEIDQVIGSHRLPTLEDRT-------KMPYTEAVIYEIQRFSD--------LI 335 Query: 364 DLAMPMADGREFNLRRG----DRLLLFPFLSPQ-RDPEIYTDPEVFKYNRFLNPDGSEKK 418 + +P ++ L RG ++P LS DP+ + P+ F + FL+ +G+ KK Sbjct: 336 PIGVPHKVTKD-TLFRGYLLPKNTEVYPILSSALHDPQYFEQPDTFNPDHFLDANGALKK 394 Query: 419 DFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDL 478 MP+ G CLG A N + F +L + L ++ V + DL Sbjct: 395 S---------EAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSL---SSPVAPKDIDL 442 Query: 479 S--RYGFGLMQPEHDVPVRYRI 498 S GFG VP Y+I Sbjct: 443 SPKESGFG------KVPQTYQI 458 Score = 28.9 bits (63), Expect = 5.1, Method: Compositional matrix adjust. Identities = 14/32 (43%), Positives = 21/32 (65%), Gaps = 3/32 (9%) Query: 49 DAASFLT---RMKEKHGDIFTILVGGRYVTVL 77 D FL R++EK+GD+FT+ +G R V +L Sbjct: 19 DRGGFLNSFRRIREKYGDVFTVHLGPRPVVML 50 >2HI4-A nrPDB Length = 495 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 45/188 (23%), Positives = 79/188 (42%), Gaps = 43/188 (22%) Query: 291 AAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLR 350 A W L++L+ PE ++ EL++++ + +P + + PQ P L++ + E+ R Sbjct: 301 AISWSLMYLVTKPEIQRKIQKELDTVIGRERRP--RLSDRPQ-----LPYLEAFILETFR 353 Query: 351 LTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQR------------DPEIY 398 ++ + +P + R+ L F P++ DPE++ Sbjct: 354 HSS--------FLPFTIPHSTTRDTTLNG--------FYIPKKCCVFVNQWQVNHDPELW 397 Query: 399 TDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLV 458 DP F+ RFL DG+ K L M +G G C+G A I F+FL Sbjct: 398 EDPSEFRPERFLTADGTAI------NKPLSEKMMLFGMGKRRCIGEVLAKWEI--FLFLA 449 Query: 459 LVHLDLEL 466 ++ LE Sbjct: 450 ILLQQLEF 457 Score = 35.4 bits (80), Expect = 0.063, Method: Compositional matrix adjust. Identities = 16/40 (40%), Positives = 24/40 (60%) Query: 38 PWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVL 77 P LG+ L GK+ L+RM +++GD+ I +G V VL Sbjct: 25 PLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVL 64 >4ZGX-A nrPDB Length = 489 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 44/165 (26%), Positives = 77/165 (46%), Gaps = 27/165 (16%) Query: 284 TQGNMGPAAFWLLLFLL---KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPV 340 T G++ AF LL+ L +NP+ +R E + + + PQK P+ Sbjct: 289 TAGSVDTTAFPLLMTLFELARNPDVQQILRQE-------SLAAAASISEHPQKATTELPL 341 Query: 341 LDSVLSESLRL-TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYT 399 L + L E+LRL F+ R V DL + + +++ G + +F + S R+ ++ Sbjct: 342 LRAALKETLRLYPVGLFLERVVSSDLVL-----QNYHIPAGTLVQVFLY-SLGRNAALFP 395 Query: 400 DPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGR 444 PE + R+L+ GS ++F+ ++P+G G CLGR Sbjct: 396 RPERYNPQRWLDIRGS-GRNFH---------HVPFGFGMRQCLGR 430 >5VEU-A nrPDB Length = 480 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 53/233 (22%), Positives = 101/233 (43%), Gaps = 35/233 (15%) Query: 271 EMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTL 330 E+ A++++ ++A + L L +P+ ++ E++++L P Sbjct: 273 ELAAQSIIF-IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVV- 330 Query: 331 PQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFN---LRRGDRLLLFP 387 LD V++E+LRL V + L E N + +G +++ P Sbjct: 331 ------QMEYLDMVVNETLRLFP-------VAIRLERTCKKDVEINGVFIPKGS-MVVIP 376 Query: 388 FLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNY-NMPWGAGHNHCLGRSY 446 + DP+ +T+PE F+ RF S+KKD + Y P+G G +C+G + Sbjct: 377 TYALHHDPKYWTEPEEFRPERF-----SKKKD------SIDPYIYTPFGTGPRNCIGMRF 425 Query: 447 AVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 499 A+ ++K + VL + + + +IP L GL+QPE + ++ R Sbjct: 426 ALMNMKLALIRVLQNFSFKPCK-ETQIP---LKLDTQGLLQPEKPIVLKVDSR 474 >5E58-A nrPDB Length = 493 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 56/257 (21%), Positives = 105/257 (40%), Gaps = 47/257 (18%) Query: 255 WLESYLLHLEEMGVSE--EMQARALVLQL----WATQGNMGPAAFWLLLFLLKNPEALAA 308 ++++YLL +E+ ++ E + L++ + +A + L +LK P Sbjct: 264 FIDTYLLRMEKEKSNQHTEFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEK 323 Query: 309 VRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLT-----AAPF-ITREVV 362 V+ E++ ++ P + T P D+V+ E R + AP +T++ + Sbjct: 324 VQKEIDQVIGSHRLPTLEDRT-------KMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTL 376 Query: 363 VDLAMPMADGREFNLRRGDRLLLFPFLSPQ-RDPEIYTDPEVFKYNRFLNPDGSEKKDFY 421 R + L + + +P LS DP+ + P F + FL+ +G+ KK Sbjct: 377 F---------RGYLLPKNTEV--YPILSSALHDPQYFEQPGTFNPDHFLDANGALKKS-- 423 Query: 422 KDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRY 481 MP+ G CLG A N + F +L + +++ V + DLS Sbjct: 424 -------EAFMPFSIGKRICLGEGIARNELFLFFTTILQNFS---VSSSVAPKDIDLSPK 473 Query: 482 GFGLMQPEHDVPVRYRI 498 G+ + VP Y+I Sbjct: 474 ESGIGK----VPQTYQI 486 Score = 29.6 bits (65), Expect = 3.1, Method: Compositional matrix adjust. Identities = 15/34 (44%), Positives = 24/34 (70%), Gaps = 1/34 (2%) Query: 44 LDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVL 77 +D G SF+ R++EK+GD+FT+ +G R V +L Sbjct: 46 MDRGGFLNSFM-RIREKYGDVFTVHLGPRPVVML 78 >6DWN-A nrPDB Length = 491 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 48/229 (20%), Positives = 100/229 (43%), Gaps = 32/229 (13%) Query: 249 RAHRSKWLESYLLHLEEMGVSEEMQAR-------ALVLQLW-ATQGNMGPAAFWLLLFLL 300 + H +S + H +E + E + +VL L+ A + A W L++L+ Sbjct: 248 KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 307 Query: 301 KNPEALAAVRGELESILWQAEQP-VSQTTTLPQKVLDSTPVLDSVLSESLRLTA-APF-I 357 NP ++ EL++++ ++ +P +S + L P +++ + E+ R ++ PF I Sbjct: 308 MNPRVQRKIQEELDTVIGRSRRPRLSDRSHL--------PYMEAFILETFRHSSFVPFTI 359 Query: 358 TREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEK 417 D ++ + F + +G R + D +++ +P F RFL PDG+ Sbjct: 360 PHSTTRDTSL-----KGFYIPKG-RCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAID 413 Query: 418 KDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLEL 466 K L + +G G C+G + A + F+ ++L ++ + Sbjct: 414 -------KVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSV 455 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 15/40 (37%), Positives = 24/40 (60%) Query: 38 PWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVL 77 P +G+ L GK+ L+RM +++GD+ I +G V VL Sbjct: 20 PLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVL 59 >5W0C-A nrPDB Length = 477 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 44/172 (25%), Positives = 75/172 (43%), Gaps = 32/172 (18%) Query: 300 LKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-----TAA 354 LK+PE A V+ E+E ++ + P Q + P D+V+ E R T+ Sbjct: 297 LKHPEVTAKVQEEIERVIGRNRSPCMQDRS-------HMPYTDAVVHEVQRYIDLLPTSL 349 Query: 355 PFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDG 414 P V D+ R + + +G +L+ S D + + +PE+F + FL+ G Sbjct: 350 P---HAVTCDIKF-----RNYLIPKGTTILI-SLTSVLHDNKEFPNPEMFDPHHFLDEGG 400 Query: 415 SEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLEL 466 + KK Y MP+ AG C+G + A ++ F+FL + + L Sbjct: 401 NFKKS---------KYFMPFSAGKRICVGEALA--GMELFLFLTSILQNFNL 441 >1N6B-A nrPDB Length = 473 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 50/204 (24%), Positives = 88/204 (43%), Gaps = 39/204 (19%) Query: 301 KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-----TAAP 355 K+PE A V+ E+E ++ + P Q + P D+V+ E R T P Sbjct: 294 KHPEVAARVQEEIERVIGRHRSPCMQDRS-------RMPYTDAVIHEIQRFIDLLPTNLP 346 Query: 356 F-ITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDG 414 +TR+V R + + +G ++ S D + + +P+VF FL+ G Sbjct: 347 HAVTRDVRF---------RNYFIPKGTDIIT-SLTSVLHDEKAFPNPKVFDPGHFLDESG 396 Query: 415 SEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIP 474 + KK +Y MP+ AG C+G A ++ F+FL + + +L + VE Sbjct: 397 NFKKS---------DYFMPFSAGKRMCVGEGLA--RMELFLFLTSILQNFKL-QSLVEPK 444 Query: 475 EFDLSRYGFGLMQPEHDVPVRYRI 498 + D++ G + VP Y++ Sbjct: 445 DLDITAVVNGFVS----VPPSYQL 464 Score = 35.0 bits (79), Expect = 0.083, Method: Compositional matrix adjust. Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 4/66 (6%) Query: 22 RRTRRPGEPPLDLGSIPWLGYALDF-GKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDP 80 ++T G+ P P +G L KD + LT+ E +G +FT+ +G + VL Sbjct: 3 KKTSSKGKLPPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVL--- 59 Query: 81 HSYDAV 86 H Y+AV Sbjct: 60 HGYEAV 65 >4GQS-A nrPDB Length = 477 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 44/171 (25%), Positives = 72/171 (42%), Gaps = 30/171 (17%) Query: 300 LKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-----TAA 354 LK+PE A V+ E+E ++ + P Q P D+V+ E R T+ Sbjct: 297 LKHPEVTAKVQEEIERVVGRNRSPCMQDR-------GHMPYTDAVVHEVQRYIDLIPTSL 349 Query: 355 PFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDG 414 P V D+ R + + +G +L S D + + +PE+F FL+ G Sbjct: 350 P---HAVTCDVKF-----RNYLIPKGTTILT-SLTSVLHDNKEFPNPEMFDPRHFLDEGG 400 Query: 415 SEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLE 465 + KK NY MP+ AG C+G A + F+ +L + +L+ Sbjct: 401 NFKKS---------NYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLK 442 >6C94-A nrPDB Length = 497 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 22/174 (12%) Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-T 352 W L + PE R E+ IL +Q Q L + L + E RL Sbjct: 304 WFLYCMALYPEHQQRCREEVREIL--GDQDSFQWEDLAKMTY-----LTMCMKECFRLYP 356 Query: 353 AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNP 412 P + R++ ++ DGR L+ + R+ +++ DPEVF RF +P Sbjct: 357 PVPQVYRQLSKPVSF--VDGRSLP---AGSLISLHIYALHRNSDVWPDPEVFDPLRF-SP 410 Query: 413 DGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLEL 466 + S + Y +P+ AG +C+G+ +A+N +K L L+ + + Sbjct: 411 ENSSGRHPYA--------FIPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSV 456 >6DA2-A nrPDB Length = 487 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 54/232 (23%), Positives = 103/232 (44%), Gaps = 32/232 (13%) Query: 271 EMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTL 330 E+ A++++ ++A +++ L +P+ ++ E++++L P T Sbjct: 274 ELVAQSIIF-IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL- 331 Query: 331 PQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFN---LRRGDRLLLFP 387 LD V++E+LRL + + L E N + +G +++ P Sbjct: 332 ------QMEYLDMVVNETLRLFP-------IAMRLERVCKKDVEINGMFIPKG-VVVMIP 377 Query: 388 FLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYA 447 + RDP+ +T+PE F RF KK+ KD Y P+G+G +C+G +A Sbjct: 378 SYALHRDPKYWTEPEKFLPERF------SKKN--KDNIDPYIYT-PFGSGPRNCIGMRFA 428 Query: 448 VNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 499 + ++K + VL + + + +IP L GL+QPE V ++ R Sbjct: 429 LMNMKLALIRVLQNFSFKPCK-ETQIP---LKLSLGGLLQPEKPVVLKVESR 476 >3EL3-A nrPDB Length = 467 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 20/69 (28%), Positives = 38/69 (55%), Gaps = 5/69 (7%) Query: 29 EPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVW 88 EPP+ G +P LG+ +D +F++++++ HGD+ I +G + V + +P A+ Sbjct: 23 EPPVAGGGVPLLGHGWRLARDPLAFMSQLRD-HGDVVRIKLGPKTVYAVTNPELTGALAL 81 Query: 89 EPRTRLDFH 97 P D+H Sbjct: 82 NP----DYH 86 Score = 30.0 bits (66), Expect = 2.5, Method: Compositional matrix adjust. Identities = 38/151 (25%), Positives = 66/151 (43%), Gaps = 26/151 (17%) Query: 293 FWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLT 352 WLL L +PE +R E+E++ +PV+ + L T +V+ E++RL Sbjct: 284 MWLLQALADHPEHADRIRDEVEAV--TGGRPVAFEDV---RKLRHT---GNVIVEAMRLR 335 Query: 353 AAPFI-TREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLN 411 A ++ TR V + + + + G ++ P+ + QRDP+ Y D F +R+L Sbjct: 336 PAVWVLTRRAVAESEL-----GGYRIPAGADIIYSPY-AIQRDPKSYDDNLEFDPDRWLP 389 Query: 412 PDGSEKKDFYKDGKRLKNYNM-PWGAGHNHC 441 + + Y M P+ AG C Sbjct: 390 ----------ERAANVPKYAMKPFSAGKRKC 410 >3E6I-A nrPDB Length = 476 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 86/208 (41%), Gaps = 35/208 (16%) Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTA 353 + LL L+K PE + E++ ++ + P K P +D+V+ E R Sbjct: 289 YGLLILMKYPEIEEKLHEEIDRVIGPSRIPAI-------KDRQEMPYMDAVVHEIQR--- 338 Query: 354 APFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYT-----DPEVFKYNR 408 FIT +V +P R+ + RG + + P D +Y DPE FK Sbjct: 339 --FIT---LVPSNLPHEATRD-TIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEH 392 Query: 409 FLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELIN 468 FLN +G K Y D Y P+ G C G A + + +L H +L+ + Sbjct: 393 FLNENGKFK---YSD------YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL- 442 Query: 469 ADVEIPEFDLS--RYGFGLMQPEHDVPV 494 V+ + DLS GFG + P + + V Sbjct: 443 --VDPKDIDLSPIHIGFGCIPPRYKLCV 468 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 20/67 (29%), Positives = 35/67 (52%), Gaps = 6/67 (8%) Query: 22 RRTRRPGEPPLDLGSIPWLG--YALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLD 79 ++T G+ P +P +G + L+ SF TR+ ++ G +FT+ VG + + V+ Sbjct: 3 KKTSSKGKLPPGPFPLPIIGNLFQLELKNIPKSF-TRLAQRFGPVFTLYVGSQRMVVM-- 59 Query: 80 PHSYDAV 86 H Y AV Sbjct: 60 -HGYKAV 65 >6IQ5-A nrPDB Length = 463 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 42/184 (22%), Positives = 77/184 (41%), Gaps = 29/184 (15%) Query: 283 ATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLD 342 A+Q + A WLLL + P+ V+ EL+ ++ + P + P + Sbjct: 263 ASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQP-------NLPYVL 315 Query: 343 SVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRR----GDRLLLFPFLSPQRDPEIY 398 + L E++R ++ V + +P A ++ D ++ S DP + Sbjct: 316 AFLYEAMRFSS--------FVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKW 367 Query: 399 TDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFL- 457 +PE F RFL+ DG KD L + M + G C+G ++ ++ F+F+ Sbjct: 368 PNPENFDPARFLDKDGLINKD-------LTSRVMIFSVGKRRCIGEE--LSKMQLFLFIS 418 Query: 458 VLVH 461 +L H Sbjct: 419 ILAH 422 >3EJB-B nrPDB Length = 404 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 30/115 (26%), Positives = 52/115 (45%), Gaps = 23/115 (20%) Query: 333 KVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQ 392 K+ ++ ++ + + E LR + +T V A D +R+G+++ L + Sbjct: 259 KLRENPDLIGTAVEECLRYESPTQMTARV----ASEDIDICGVTIRQGEQVYLL-LGAAN 313 Query: 393 RDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYA 447 RDP I+T+P+VF R NP ++ +G GH+ CLG S A Sbjct: 314 RDPSIFTNPDVFDITRSPNP------------------HLSFGHGHHVCLGSSLA 350 >2NNH-A nrPDB Length = 476 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 39/172 (22%), Positives = 71/172 (41%), Gaps = 26/172 (15%) Query: 301 KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLT--AAPFIT 358 K+PE A V+ E++ ++ + P Q + P D+V+ E R + + Sbjct: 297 KHPEVTAKVQEEIDHVIGRHRSPCMQDRS-------HMPYTDAVVHEIQRYSDLVPTGVP 349 Query: 359 REVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKK 418 V D R + + +G ++ S D + + +P +F FL+ +G+ KK Sbjct: 350 HAVTTDTKF-----RNYLIPKGTTIMAL-LTSVLHDDKEFPNPNIFDPGHFLDKNGNFKK 403 Query: 419 DFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINAD 470 +Y MP+ AG C G A ++ F+FL + + L + D Sbjct: 404 S---------DYFMPFSAGKRICAGEGLA--RMELFLFLTTILQNFNLKSVD 444 >5UYS-A nrPDB Length = 494 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 48/187 (25%), Positives = 85/187 (45%), Gaps = 35/187 (18%) Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-- 351 W L FLL NP+ + E++ + + P T + ++L +L++ + E LRL Sbjct: 295 WTLAFLLHNPQVKKKLYEEIDQNVGFSRTP---TISDRNRLL----LLEATIREVLRLRP 347 Query: 352 TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLN 411 A I + VD ++ EF + +G +++ + + E + P+ F RFLN Sbjct: 348 VAPMLIPHKANVDSSI-----GEFAVDKGTEVIINLWALHHNEKE-WHQPDQFMPERFLN 401 Query: 412 PDGSE---KKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELIN 468 P G++ Y +P+GAG C+G A +Q +FL++ L L Sbjct: 402 PAGTQLISPSVSY----------LPFGAGPRSCIGEILA----RQELFLIMAWL---LQR 444 Query: 469 ADVEIPE 475 D+E+P+ Sbjct: 445 FDLEVPD 451 >4H1N-A nrPDB Length = 479 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 58/255 (22%), Positives = 95/255 (37%), Gaps = 41/255 (16%) Query: 255 WLESYLLHLEE--MGVSEEMQARAL---VLQLWATQGNMGPAAF-WLLLFLLKNPEALAA 308 +++ YLL +E+ S E + L VL L+A + L +LK P Sbjct: 245 FIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLKYPHVTER 304 Query: 309 VRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMP 368 V+ E+E ++ P P D+V+ E RL ++ +P Sbjct: 305 VQKEIEQVIGSHRPPALDDRA-------KMPYTDAVIHEIQRLGD--------LIPFGVP 349 Query: 369 MADGREFNLRR---GDRLLLFPFLSPQ-RDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDG 424 ++ R +FP LS DP + P F FL+ +G+ K++ Sbjct: 350 HTVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRN----- 404 Query: 425 KRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFG 484 MP+ G CLG A + F +L + I + V + DL+ G Sbjct: 405 ----EGFMPFSLGKRICLGEGIARTELFLFFTTILQNFS---IASPVPPEDIDLTPRESG 457 Query: 485 LMQPEHDVPVRYRIR 499 + +VP Y+IR Sbjct: 458 V----GNVPPSYQIR 468 Score = 36.2 bits (82), Expect = 0.031, Method: Compositional matrix adjust. Identities = 22/59 (37%), Positives = 33/59 (55%), Gaps = 3/59 (5%) Query: 22 RRTRRPGEPPLDLGSIPWLGYALDFGKDA--ASFLTRMKEKHGDIFTILVGGRYVTVLL 78 ++T G+ P +P LG L + SFL R++EK+GD+FT+ +G R V VL Sbjct: 3 KKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFL-RLREKYGDVFTVYLGSRPVVVLC 60 >1CPT-A nrPDB Length = 428 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 19/82 (23%) Query: 373 REFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNM 432 R N++RGDR++L + S RD E++++P+ F RF N ++ Sbjct: 328 RGQNIKRGDRIML-SYPSANRDEEVFSNPDEFDITRFPN----------------RHLGF 370 Query: 433 PWGAGHNHCLGRSYAVNSIKQF 454 WGA + CLG+ A +K F Sbjct: 371 GWGA--HMCLGQHLAKLEMKIF 390 >5VBU-A nrPDB Length = 476 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 44/173 (25%), Positives = 74/173 (42%), Gaps = 33/173 (19%) Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTA 353 W ++FLL +PE ++ EL+ L P + ++ +P K P+L++ ++E LRL Sbjct: 284 WAVVFLLHHPEIQQRLQEELDHEL----GPGASSSRVPYKDRARLPLLNATIAEVLRLRP 339 Query: 354 APFITREVVVDLAMPMADGREFNLRRGD---RLLLFPFL-SPQRDPEIYTDPEVFKYNRF 409 VV LA+P R ++ D ++ P L D ++ P F +RF Sbjct: 340 --------VVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRF 391 Query: 410 LNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHL 462 L P + + + +G G CLG A + +F+VL L Sbjct: 392 LEPGKNSRA-------------LAFGCGARVCLGEPLA----RLELFVVLTRL 427 >3DL9-A nrPDB Length = 479 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 41/170 (24%), Positives = 66/170 (38%), Gaps = 32/170 (18%) Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTA 353 W +LF+ P V+ E++ I+ +P P ++VL E LR Sbjct: 295 WAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKC-------KMPYTEAVLHEVLRFCN 347 Query: 354 APFITREVVVDLAMPMADG-----REFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNR 408 +V L + A R +++ +G ++ S D + + DPEVF R Sbjct: 348 --------IVPLGIFHATSEDAVVRGYSIPKGTTVIT-NLYSVHFDEKYWRDPEVFHPER 398 Query: 409 FLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLV 458 FL+ G K K +P+ G HCLG A ++ F+F Sbjct: 399 FLDSSGYFAK---------KEALVPFSLGRRHCLGEHLA--RMEMFLFFT 437 >3QZ1-A nrPDB Length = 496 Score = 37.4 bits (85), Expect = 0.013, Method: Compositional matrix adjust. Identities = 40/158 (25%), Positives = 65/158 (41%), Gaps = 29/158 (18%) Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTA 353 W + FLL +PE ++ EL+ L P + + + K P+L++ ++E LRL Sbjct: 301 WAVAFLLHHPEIQRRLQEELDREL----GPGASCSRVTYKDRARLPLLNATIAEVLRLRP 356 Query: 354 APFITREVVVDLAMPMADGRE---FNLRRGDRLLLFPFL-SPQRDPEIYTDPEVFKYNRF 409 VV LA+P R F + +++ P L D ++ P F+ +RF Sbjct: 357 --------VVPLALPHRTTRPSSIFGYDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRF 408 Query: 410 LNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYA 447 L P + + +G G CLG S A Sbjct: 409 LEPGANPSA-------------LAFGCGARVCLGESLA 433 >3NC3-A nrPDB Length = 441 Score = 37.4 bits (85), Expect = 0.016, Method: Compositional matrix adjust. Identities = 53/232 (22%), Positives = 90/232 (38%), Gaps = 44/232 (18%) Query: 231 CSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVS-EEMQARALVLQLWATQGNMG 289 CS +L + L P RR + L S L E G++ + AL+L + Sbjct: 217 CS--EQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMALSDKDILALILNVLLAATEPA 274 Query: 290 PAAFWLLLF-LLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSES 348 L+++ LL NPE + VL ++ ++E+ Sbjct: 275 DKTLALMIYHLLNNPEQM-------------------------NDVLADRSLVPRAIAET 309 Query: 349 LRLTA-APFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYN 407 LR I R++ D + G E + D ++ + RDPE + P+VF + Sbjct: 310 LRYKPPVQLIPRQLSQDTVV---GGMEI---KKDTIVFCMIGAANRDPEAFEQPDVFNIH 363 Query: 408 RFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVL 459 R D K F + L +G+G ++C+G ++A N I+ +VL Sbjct: 364 R---EDLGIKSAFSGAARHLA-----FGSGIHNCVGTAFAKNEIEIVANIVL 407 >3N9Z-A nrPDB Length = 487 Score = 35.4 bits (80), Expect = 0.057, Method: Compositional matrix adjust. Identities = 41/174 (23%), Positives = 75/174 (43%), Gaps = 24/174 (13%) Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTA 353 W L + +N + +R E+ + QA+ ++ +L P+L + + E+LRL Sbjct: 297 WHLYEMARNLKVQDMLRAEVLAARHQAQGDMA-------TMLQLVPLLKASIKETLRLHP 349 Query: 354 APF-ITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNP 412 + R +V DL + R++ + L+ + R+P + DPE F R+L+ Sbjct: 350 ISVTLQRYLVNDLVL-----RDYMIP-AKTLVQVAIYALGREPTFFFDPENFDPTRWLSK 403 Query: 413 DGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLEL 466 D K+ +N WG CLGR A + F+ +L + +E+ Sbjct: 404 D--------KNITYFRNLGFGWGV--RQCLGRRIAELEMTIFLINMLENFRVEI 447 >3MDV-A nrPDB Length = 456 Score = 33.1 bits (74), Expect = 0.26, Method: Compositional matrix adjust. Identities = 40/174 (22%), Positives = 71/174 (40%), Gaps = 23/174 (13%) Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTA 353 + ++ L + PE +A ++ E++ + + L + L L VL ESLRL Sbjct: 265 FTVMELSRQPEIVARLQAEVDEV-------IGSKRYLDFEDLGRLQYLSQVLKESLRLYP 317 Query: 354 APFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPD 413 + T ++ + + DG G+ LLF R + DP F +RF P Sbjct: 318 PAWGTFRLLEEETL--IDGVRVP---GNTPLLFSTYVMGRMDTYFEDPLTFNPDRF-GPG 371 Query: 414 GSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELI 467 + + Y P+ GH C+G+ +A +K + +L L+ L+ Sbjct: 372 APKPRFTY----------FPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLV 415 >6FYJ-A nrPDB Length = 421 Score = 33.1 bits (74), Expect = 0.29, Method: Compositional matrix adjust. Identities = 30/97 (30%), Positives = 41/97 (42%), Gaps = 15/97 (15%) Query: 383 LLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCL 442 L L DPEI+ +P+VF +RF +GS + G +Y M GH C Sbjct: 317 LTLLDLYGTNHDPEIWKNPDVFSPDRFAKWEGSPFSFIPQGG---GDYFM----GH-RCA 368 Query: 443 GRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLS 479 G + +K V LD D E+P+ DLS Sbjct: 369 GEWVTIEVMK-------VSLDYLTNRMDYEVPDQDLS 398 >5EX6-C nrPDB Length = 434 Score = 32.3 bits (72), Expect = 0.53, Method: Compositional matrix adjust. Identities = 50/222 (22%), Positives = 84/222 (37%), Gaps = 55/222 (24%) Query: 268 VSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQT 327 V++E V + A N+ +L LL+NPE +AA+RG++ + AE+ V + Sbjct: 257 VTDEELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAALRGDVPA----AERAVDEL 312 Query: 328 T---TLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLL 384 T+P T + DS + + + I V ++P A+ Sbjct: 313 IRYLTVPYAPTPRTAIEDSTVGDQV-------IKAGETVLCSLPTAN------------- 352 Query: 385 LFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGR 444 RDP + D + R P ++ +G G +HCLG Sbjct: 353 --------RDPALLPDADRLDVTREAVP------------------HVAFGHGVHHCLGA 386 Query: 445 SYAVNSIK-QFVFLVLVHLDLELINADVEIPEFDLSRYGFGL 485 + A ++ + L DL L + D EF LS +G+ Sbjct: 387 ALARLELRIAYTALWRRFPDLRLADPDGAT-EFRLSTPAYGI 427 >6G71-A nrPDB Length = 405 Score = 32.0 bits (71), Expect = 0.70, Method: Compositional matrix adjust. Identities = 33/111 (29%), Positives = 50/111 (45%), Gaps = 25/111 (22%) Query: 334 VLDSTPVLDSVLSESLRLTAA-PFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQ 392 VL + +V ES+R A + R+ VVD + DG + + RG +L L LS Sbjct: 262 VLRDPKLWGAVFEESIRWVAPIGMVPRQTVVDTEL---DG--YFIPRGAKLGLC-ILSAN 315 Query: 393 RDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLG 443 RD +++DP+ F R GSE ++ +G G + CLG Sbjct: 316 RDRSVWSDPDRFDIER-----GSEA-------------HLAFGKGVHVCLG 348 >4WPZ-A nrPDB Length = 397 Score = 31.2 bits (69), Expect = 0.99, Method: Compositional matrix adjust. Identities = 17/56 (30%), Positives = 23/56 (41%), Gaps = 18/56 (32%) Query: 392 QRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYA 447 RDPE++ D E R NP ++ +GAG +HCLG A Sbjct: 315 NRDPEVFEDGERLNVTRENNP------------------HLAFGAGIHHCLGAQLA 352 >1WIY-A nrPDB Length = 389 Score = 31.2 bits (69), Expect = 1.0, Method: Compositional matrix adjust. Identities = 30/104 (28%), Positives = 48/104 (46%), Gaps = 18/104 (17%) Query: 345 LSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVF 404 E+LRL +I + L P+ G E L +G L+L P+++ QR + + E F Sbjct: 258 FQEALRLYPPAWI---LTRRLERPLLLG-EDRLPQGTTLVLSPYVT-QRL--YFPEGEAF 310 Query: 405 KYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAV 448 + RFL G+ ++ P+G G CLGR +A+ Sbjct: 311 QPERFLAERGTPSGRYF-----------PFGLGQRLCLGRDFAL 343 >5DE9-A nrPDB Length = 410 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 13/36 (36%), Positives = 22/36 (61%), Gaps = 1/36 (2%) Query: 377 LRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNP 412 +R GD + + +L+ RDPE++ DP+ + R NP Sbjct: 308 IRAGDAVYVS-YLAANRDPEVFPDPDRIDFERSPNP 342 >3S79-A nrPDB Length = 503 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 40/198 (20%), Positives = 80/198 (40%), Gaps = 39/198 (19%) Query: 268 VSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQT 327 ++ E + ++ L A M + F++L + K+P A+ E+++++ + + + Sbjct: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDI 350 Query: 328 TTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMA------DGREFNLRRGD 381 L V+++ + ES+R + VVDL M A DG + +++G Sbjct: 351 QKLK--------VMENFIYESMRY--------QPVVDLVMRKALEDDVIDG--YPVKKGT 392 Query: 382 RLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHC 441 ++L + E + P F F K Y+ Y P+G G C Sbjct: 393 NIILN--IGRMHRLEFFPKPNEFTLENF------AKNVPYR-------YFQPFGFGPRGC 437 Query: 442 LGRSYAVNSIKQFVFLVL 459 G+ A+ +K + +L Sbjct: 438 AGKYIAMVMMKAILVTLL 455 >4IAO-A nrPDB Length = 492 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 18/44 (40%), Positives = 25/44 (56%), Gaps = 1/44 (2%) Query: 441 CLGRSYAVNSIKQFVFLVLVHLDLELINAD-VEIPEFDLSRYGF 483 C+G S V + + V +V H+ LIN D V+ EFDLS G+ Sbjct: 399 CIGTSLKVAPVSEIVNMVPSHVPQVLINRDPVKHAEFDLSLLGY 442 >2HJH-A nrPDB Length = 354 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 18/44 (40%), Positives = 25/44 (56%), Gaps = 1/44 (2%) Query: 441 CLGRSYAVNSIKQFVFLVLVHLDLELINAD-VEIPEFDLSRYGF 483 C+G S V + + V +V H+ LIN D V+ EFDLS G+ Sbjct: 261 CIGTSLKVAPVSEIVNMVPSHVPQVLINRDPVKHAEFDLSLLGY 304 >6A0P-A nrPDB Length = 413 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 25/91 (27%), Positives = 39/91 (42%), Gaps = 9/91 (9%) Query: 51 ASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAI-------FL 103 ++ +++ FTI +TV + + +V EPR L+ AY I FL Sbjct: 154 GNYSSQLGASQAGRFTITPNSPAITVKMGDYGEISVECEPRNGLNTEAYYIMSVGTKHFL 213 Query: 104 MER--IFDVQLPHYSPSDEKARMKLTLLHRE 132 + R D+ LP SP+ R + LL E Sbjct: 214 VHREWFNDLALPWTSPASSNWRNREILLEFE 244 >6B11-A nrPDB Length = 440 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 31/124 (25%), Positives = 56/124 (45%), Gaps = 25/124 (20%) Query: 340 VLDSVLSESLR-LTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIY 398 +L + E LR L+ A + R D+ + DG +R GD L+ F + RD ++ Sbjct: 311 LLPGAVDELLRYLSIADGLRRSATADIEI---DG--HTIRAGDGLV-FLLAAANRDEAVF 364 Query: 399 TDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLV 458 ++PE F D ++ +R ++ +G G + CLG++ A ++ + V Sbjct: 365 SEPEAF--------------DIHRSARR----HVAFGYGPHQCLGQNLARMELEVALGAV 406 Query: 459 LVHL 462 L L Sbjct: 407 LERL 410 >2NZA-A nrPDB Length = 413 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 18/75 (24%), Positives = 31/75 (41%), Gaps = 18/75 (24%) Query: 388 FLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYA 447 +L+ RDP+++ DP+ +R NP ++ +G GH+ C G A Sbjct: 321 YLAANRDPDVFPDPDRIDLDRDPNP------------------HLAYGNGHHFCTGAVLA 362 Query: 448 VNSIKQFVFLVLVHL 462 + V +L L Sbjct: 363 RMQTELLVDTLLERL 377 >4XE3-A nrPDB Length = 407 Score = 30.0 bits (66), Expect = 2.3, Method: Compositional matrix adjust. Identities = 23/101 (22%), Positives = 47/101 (46%), Gaps = 21/101 (20%) Query: 343 SVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPE 402 + + E LR T P ++ V +A + +R G+ ++ F S RD E++ Sbjct: 279 AAVEEMLRYT--PLVSAGSFVRVATEDVELSTVTVRAGEPCVVH-FASANRDEEVF---- 331 Query: 403 VFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLG 443 D +++ DF+++ +N ++ +G G +HC+G Sbjct: 332 ----------DHADELDFHRE----RNPHIAFGHGAHHCIG 358 >2WIY-A nrPDB Length = 394 Score = 30.0 bits (66), Expect = 2.5, Method: Compositional matrix adjust. Identities = 15/53 (28%), Positives = 25/53 (47%), Gaps = 16/53 (30%) Query: 392 QRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGR 444 RDPE++ DP+VF + R P + + N+ +G G + C G+ Sbjct: 312 NRDPEVFDDPDVFDHTR---PPAASR-------------NLSFGLGPHSCAGQ 348 >5L94-A nrPDB Length = 410 Score = 29.6 bits (65), Expect = 2.9, Method: Compositional matrix adjust. Identities = 18/54 (33%), Positives = 23/54 (42%), Gaps = 18/54 (33%) Query: 390 SPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLG 443 S RD E + DPEVFK + R N +M +G G + CLG Sbjct: 319 SAHRDAEYFEDPEVFKID------------------RKPNVHMAFGRGIHFCLG 354 >3IBD-A nrPDB Length = 476 Score = 29.6 bits (65), Expect = 3.5, Method: Compositional matrix adjust. Identities = 49/255 (19%), Positives = 94/255 (36%), Gaps = 43/255 (16%) Query: 256 LESYLLHLEEMGVS-------EEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAA 308 +++YLLH+E+ + + + L L T+ + LL +LK P Sbjct: 246 IDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLL-MLKYPHVAER 304 Query: 309 VRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMP 368 V E+E ++ P P ++V+ E R + ++ + +P Sbjct: 305 VYREIEQVIGPHRPPELHDRA-------KMPYTEAVIYEIQRFSD--------LLPMGVP 349 Query: 369 MADGREFNLRR----GDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDG 424 + + R D + + DP + P+ F + FL+ +G+ KK Sbjct: 350 HIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK------ 403 Query: 425 KRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFG 484 +P+ G CLG A + F +L + + + V + DL+ G Sbjct: 404 ---TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMA---SPVAPEDIDLTPQECG 457 Query: 485 LMQPEHDVPVRYRIR 499 + + +P Y+IR Sbjct: 458 VGK----IPPTYQIR 468 Score = 28.9 bits (63), Expect = 6.0, Method: Compositional matrix adjust. Identities = 14/27 (51%), Positives = 20/27 (74%), Gaps = 1/27 (3%) Query: 52 SFLTRMKEKHGDIFTILVGGRYVTVLL 78 SFL R +EK+GD+FT+ +G R V +L Sbjct: 35 SFL-RFREKYGDVFTVHLGPRPVVMLC 60 >1GAN-A nrPDB Length = 134 Score = 28.9 bits (63), Expect = 4.9, Method: Composition-based stats. Identities = 17/52 (32%), Positives = 28/52 (53%), Gaps = 5/52 (9%) Query: 26 RPGEPPLDLGSIP--WLGYALDFGKDAASFLTRMKEK---HGDIFTILVGGR 72 +PG GSIP G+A++ G+DA++FL + HGD+ I+ + Sbjct: 13 KPGHCVEIKGSIPPDCKGFAVNLGEDASNFLLHFNARFDLHGDVNKIVCNSK 64 >2Z36-A nrPDB Length = 413 Score = 28.5 bits (62), Expect = 6.2, Method: Compositional matrix adjust. Identities = 25/113 (22%), Positives = 48/113 (42%), Gaps = 22/113 (19%) Query: 384 LLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLG 443 ++ LS DP ++ DP V D +R +++ +G G + CLG Sbjct: 317 VIVSMLSANWDPAVFKDPAVL------------------DVERGARHHLAFGFGPHQCLG 358 Query: 444 RSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRY 496 ++ A + Q VF L + + + +P D+ G ++ H++PV + Sbjct: 359 QNLARMEL-QIVFDTLFR---RIPSLRLAVPMEDVPFKGDSVIYGVHELPVTW 407 >2RCM-A nrPDB Length = 495 Score = 28.5 bits (62), Expect = 7.0, Method: Compositional matrix adjust. Identities = 34/154 (22%), Positives = 65/154 (42%), Gaps = 17/154 (11%) Query: 325 SQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE---VVVDLAMPMADGREFNLRRGD 381 S L ++ + SV+ E LR P +T + DL + D F ++ G+ Sbjct: 331 SNGGELTMGAIEKMELTKSVVYECLRF--EPPVTAQYGRAKKDLVIESHDA-AFKVKAGE 387 Query: 382 RLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSE--KKDFYKDGKRLKNYNMPWGAGHN 439 L + L+ RDP+I+ + F RF+ +G + + + +G + + G+ Sbjct: 388 MLYGYQPLA-TRDPKIFDRADEFVPERFVGEEGEKLLRHVLWSNGPETETPTV----GNK 442 Query: 440 HCLGRSYAVNSIKQFVFLVLVHLDLELINADVEI 473 C G+ + V + FV + D + D+E+ Sbjct: 443 QCAGKDFVVLVARLFVIEIFRRYD----SFDIEV 472 >2XWE-A nrPDB Length = 505 Score = 28.1 bits (61), Expect = 8.4, Method: Compositional matrix adjust. Identities = 14/49 (28%), Positives = 24/49 (48%) Query: 86 VVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQ 134 ++ P DF + D QL ++S +E ++K+ L+HR LQ Sbjct: 120 IIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQ 168 >4TX3-A nrPDB Length = 404 Score = 28.1 bits (61), Expect = 8.9, Method: Compositional matrix adjust. Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 6/92 (6%) Query: 275 RALVLQLW-ATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTT---- 329 R + +QL A N+ +L LL++PE +AA+RG+ +S ++ + T Sbjct: 233 RGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQSADRAVDELIRYLTVPYAP 292 Query: 330 LPQKVLDSTPVLDSVLSES-LRLTAAPFITRE 360 P+ ++ V D V+ E L + P R+ Sbjct: 293 TPRTAVEDVMVADQVIKEGETVLCSLPMANRD 324 >6FSH-A nrPDB Length = 398 Score = 28.1 bits (61), Expect = 9.0, Method: Compositional matrix adjust. Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 6/92 (6%) Query: 275 RALVLQLW-ATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTT---- 329 R + +QL A N+ +L LL++PE +AA+RG+ +S ++ + T Sbjct: 227 RGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQSADRAVDELIRYLTVPYAP 286 Query: 330 LPQKVLDSTPVLDSVLSES-LRLTAAPFITRE 360 P+ ++ V D V+ E L + P R+ Sbjct: 287 TPRTAVEDVMVADQVIKEGETVLCSLPMANRD 318 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2IAG-A nrPDB 558 e-159 3B98-A nrPDB 471 e-133 3SN5-A nrPDB 438 e-123 4WMZ-A nrPDB 418 e-117 2WX2-A nrPDB 412 e-115 5JLC-A nrPDB 409 e-114 3L4D-A nrPDB 400 e-112 6AYB-A nrPDB 398 e-111 2X2N-A nrPDB 394 e-110 3JUS-A nrPDB 393 e-109 6CR2-A nrPDB 385 e-107 5FSA-A nrPDB 361 e-100 2W0A-A nrPDB 346 1e-95 5E0E-A nrPDB 231 5e-61 6DWN-A nrPDB 228 3e-60 5E58-A nrPDB 226 2e-59 6DA2-A nrPDB 226 2e-59 6B82-A nrPDB 223 2e-58 2PG7-A nrPDB 223 2e-58 1N6B-A nrPDB 219 2e-57 3E6I-A nrPDB 217 1e-56 5VEU-A nrPDB 216 2e-56 5W0C-A nrPDB 213 1e-55 4GQS-A nrPDB 213 2e-55 3EL3-A nrPDB 207 1e-53 4R20-A nrPDB 199 2e-51 2HI4-A nrPDB 198 4e-51 4R1Z-A nrPDB 197 7e-51 5YLW-A nrPDB 194 9e-50 2VE3-A nrPDB 185 3e-47 4KPA-A nrPDB 185 3e-47 3K9V-A nrPDB 184 7e-47 6C94-A nrPDB 183 2e-46 6M7X-A nrPDB 127 1e-29 4ZGX-A nrPDB 125 4e-29 Sequences not found previously or not previously below threshold: 4H1N-A nrPDB 231 6e-61 3IBD-A nrPDB 209 2e-54 2NNH-A nrPDB 205 3e-53 3TBG-A nrPDB 179 3e-45 5UYS-A nrPDB 178 4e-45 3DL9-A nrPDB 176 2e-44 6IQ5-A nrPDB 160 1e-39 3MDV-A nrPDB 160 2e-39 3QZ1-A nrPDB 157 1e-38 5VBU-A nrPDB 153 1e-37 3N9Z-A nrPDB 140 1e-33 3MZS-A nrPDB 136 2e-32 3S79-A nrPDB 115 4e-26 3NC3-A nrPDB 99 3e-21 3EJB-B nrPDB 96 3e-20 1CPT-A nrPDB 92 4e-19 1WIY-A nrPDB 90 3e-18 4GGV-A nrPDB 87 2e-17 2VZM-A nrPDB 87 2e-17 5L94-A nrPDB 86 4e-17 5VWS-A nrPDB 82 4e-16 4WPZ-A nrPDB 81 1e-15 5EX6-C nrPDB 81 1e-15 3TKT-A nrPDB 80 2e-15 4RM4-A nrPDB 80 3e-15 1ODO-A nrPDB 80 3e-15 5CJE-A nrPDB 79 4e-15 1LG9-A nrPDB 79 6e-15 2WIO-A nrPDB 78 7e-15 1Z8P-A nrPDB 78 8e-15 6GK6-A nrPDB 77 1e-14 5IT1-A nrPDB 77 2e-14 5OFQ-A nrPDB 77 2e-14 4YZR-A nrPDB 76 3e-14 4YT3-A nrPDB 76 4e-14 6G5O-A nrPDB 76 4e-14 6FYJ-A nrPDB 76 4e-14 3RWL-A nrPDB 76 4e-14 3P3Z-A nrPDB 75 5e-14 1EHE-A nrPDB 75 6e-14 3TYW-A nrPDB 75 8e-14 3R9C-A nrPDB 75 9e-14 2Y5N-A nrPDB 75 1e-13 5Y1I-A nrPDB 74 1e-13 5XJN-A nrPDB 74 1e-13 5GWE-A nrPDB 74 1e-13 4JBT-A nrPDB 74 1e-13 6HQG-A nrPDB 74 2e-13 5YHJ-A nrPDB 74 2e-13 3OFT-A nrPDB 73 2e-13 4TRI-A nrPDB 73 2e-13 5XNT-A nrPDB 73 2e-13 5FOI-A nrPDB 73 3e-13 6GMF-A nrPDB 73 3e-13 5LIV-A nrPDB 73 3e-13 4OQS-A nrPDB 73 3e-13 2ZQJ-A nrPDB 73 4e-13 6B11-A nrPDB 72 4e-13 6FSH-A nrPDB 72 4e-13 2RCM-A nrPDB 72 5e-13 6F88-A nrPDB 72 6e-13 4TX3-A nrPDB 72 7e-13 4Z5P-A nrPDB 72 7e-13 6A7J-A nrPDB 71 1e-12 5L1U-A nrPDB 71 1e-12 2Z36-A nrPDB 70 2e-12 3ABB-A nrPDB 70 2e-12 3DBM-A nrPDB 70 2e-12 6F0B-A nrPDB 70 2e-12 1Q5D-A nrPDB 70 3e-12 6CVC-A nrPDB 69 5e-12 6A7I-A nrPDB 69 6e-12 2ZBZ-A nrPDB 69 6e-12 4OQR-A nrPDB 68 6e-12 3ABA-A nrPDB 68 6e-12 5LIE-A nrPDB 68 6e-12 3WVS-A nrPDB 68 7e-12 3A50-A nrPDB 68 9e-12 2XKR-A nrPDB 68 9e-12 6G71-A nrPDB 68 9e-12 3MGX-A nrPDB 68 1e-11 5YSW-A nrPDB 68 1e-11 1GWI-A nrPDB 67 2e-11 4UBS-A nrPDB 67 2e-11 6DCD-A nrPDB 66 3e-11 1UED-A nrPDB 66 4e-11 5DE9-A nrPDB 65 7e-11 5DQN-A nrPDB 65 7e-11 5Z9I-A nrPDB 65 8e-11 5HDI-A nrPDB 65 8e-11 4C9K-A nrPDB 64 9e-11 4MM0-A nrPDB 64 1e-10 5HIW-A nrPDB 64 1e-10 5XW2-A nrPDB 64 1e-10 3NV6-A nrPDB 64 1e-10 3AWQ-A nrPDB 63 2e-10 4XE3-A nrPDB 63 3e-10 2NZA-A nrPDB 63 4e-10 5M0P-A nrPDB 63 4e-10 3IVY-A nrPDB 63 4e-10 5FYF-A nrPDB 62 5e-10 2WM5-A nrPDB 62 6e-10 5NWS-A nrPDB 61 9e-10 3BUJ-A nrPDB 61 1e-09 6GII-A nrPDB 61 1e-09 1F4U-A nrPDB 60 2e-09 2QBO-A nrPDB 60 2e-09 2X9P-A nrPDB 60 2e-09 4PWV-A nrPDB 60 2e-09 3OO3-A nrPDB 58 8e-09 6HQD-A nrPDB 58 9e-09 2WIY-A nrPDB 58 9e-09 1UE8-A nrPDB 58 9e-09 4Z5Q-A nrPDB 58 9e-09 3A1L-A nrPDB 58 1e-08 2RFC-A nrPDB 57 1e-08 5KYO-A nrPDB 57 2e-08 2FR7-A nrPDB 56 3e-08 5OMS-A nrPDB 54 1e-07 4DO1-A nrPDB 53 2e-07 5HH3-A nrPDB 53 3e-07 6HQW-A nrPDB 52 7e-07 6M7L-A nrPDB 52 7e-07 5H1Z-A nrPDB 49 3e-06 3WEC-A nrPDB 49 3e-06 5D3U-A nrPDB 48 1e-05 5EX8-A nrPDB 46 5e-05 2UUQ-A nrPDB 44 1e-04 4FB2-A nrPDB 44 1e-04 2IJ7-A nrPDB 44 2e-04 6BLD-A nrPDB 43 4e-04 2YJN-B nrPDB 32 0.52 1H2T-C nrPDB 31 0.92 5OVN-A nrPDB 31 1.3 4KVO-A nrPDB 31 1.8 5C8J-I nrPDB 30 2.4 2Y05-A nrPDB 29 3.3 >2IAG-A nrPDB Length = 482 Score = 558 bits (1437), Expect = e-159, Method: Composition-based stats. Identities = 478/478 (100%), Positives = 478/478 (100%) Query: 23 RTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHS 82 RTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHS Sbjct: 1 RTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHS 60 Query: 83 YDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYT 142 YDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYT Sbjct: 61 YDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYT 120 Query: 143 NLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSAD 202 NLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSAD Sbjct: 121 NLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSAD 180 Query: 203 VFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLH 262 VFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLH Sbjct: 181 VFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLH 240 Query: 263 LEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQ 322 LEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQ Sbjct: 241 LEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQ 300 Query: 323 PVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDR 382 PVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDR Sbjct: 301 PVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDR 360 Query: 383 LLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCL 442 LLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCL Sbjct: 361 LLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCL 420 Query: 443 GRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP 500 GRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP Sbjct: 421 GRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP 478 >3B98-A nrPDB Length = 475 Score = 471 bits (1211), Expect = e-133, Method: Composition-based stats. Identities = 228/485 (47%), Positives = 320/485 (65%), Gaps = 25/485 (5%) Query: 18 LLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVL 77 +L RRTRR EPPLD G IPWLG+AL+FGKDAA FLTRMKEKHGDIFT+ G Y+TVL Sbjct: 8 VLYGRRTRRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVL 67 Query: 78 LDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALT 137 LD + YDAV+ + + LD +YA LM+RIF++ LP ++P EK R ++ L L+ Sbjct: 68 LDSNCYDAVLSDVAS-LDQTSYAQVLMKRIFNMILPSHNPESEKKRAEMHFQGASLTQLS 126 Query: 138 EAMYTNLHAVLLGDATEAG---SGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQA 194 +M NL LL +E G S W + GL + YS L + GYLT++G E Sbjct: 127 NSMQNNLR--LLMTPSEMGLKTSEWKKDGLFNLCYSLLFKTGYLTVFGAEN--------- 175 Query: 195 QDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSK 254 + ++ FR+ D+LLPKLAR +++ +K + + +LWK L+P+ L R+ Sbjct: 176 NNSAALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASAAREKLWKWLTPSGLDRKPREQS 235 Query: 255 WLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELE 314 WL SY+ L++ G+ EMQ RA++LQLW TQGN GPAAFW++ +LL +PEAL AVR E++ Sbjct: 236 WLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQ 295 Query: 315 SILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGRE 374 + L ++ +TPV DSVL E+LRLTAA ITR+V D + +++G+E Sbjct: 296 G---------GKHLRLEERQ-KNTPVFDSVLWETLRLTAAALITRDVTQDKKICLSNGQE 345 Query: 375 FNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPW 434 ++LRRGDRL +FPF+SPQ DP+I+ PE+F+++RFLN D +EKKDF+K+G R+K ++PW Sbjct: 346 YHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVKYPSVPW 405 Query: 435 GAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPV 494 G N C GR +AV++IK+ VF +L D+EL + + +P D SRYGFG++QP D+ + Sbjct: 406 GTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDLEI 465 Query: 495 RYRIR 499 RYRIR Sbjct: 466 RYRIR 470 >3SN5-A nrPDB Length = 491 Score = 438 bits (1127), Expect = e-123, Method: Composition-based stats. Identities = 161/490 (32%), Positives = 255/490 (52%), Gaps = 19/490 (3%) Query: 20 SRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLD 79 + R R+ GEPPL+ G IP+LG AL FG + FL + KHG +FT + G+YV + + Sbjct: 5 TSSRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITN 64 Query: 80 PHSYDAVVWEPR----TRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQA 135 P SY V+ + + F A R D + + + +K TL L + Sbjct: 65 PLSYHKVLCHGKYFDWKKFHFALSAKAFGHRSIDPMDGNTTENINDTFIK-TLQGHALNS 123 Query: 136 LTEAMYTNLHAVLLG--DATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQ 193 LTE+M NL ++ + + W G+ F Y + AGYLT++G + R + Sbjct: 124 LTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQ-- 181 Query: 194 AQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRS 253 + H + F+Q D++ P L G L + + + +L + L L +R S Sbjct: 182 ---KAHILNNLDNFKQFDKVFPALVAG-LPIHMFRTAHNAREKLAESLRHENLQKRESIS 237 Query: 254 KWLESYLLHLEEMGVSEE-MQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGE 312 + + + + + ++ +A+ ++ LWA+Q N PA FW L +++NPEA+ A E Sbjct: 238 ELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEE 297 Query: 313 LESILWQAEQPVS---QTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPM 369 ++ L A Q VS L Q L+ PVLDS++ ESLRL++A R D + + Sbjct: 298 VKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHL 357 Query: 370 ADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKN 429 DG +N+R+ D + L+P L DPEIY DP FKY+R+L+ +G K FY +G +LK Sbjct: 358 EDG-SYNIRKDDIIALYPQLM-HLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKY 415 Query: 430 YNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPE 489 Y MP+G+G C GR +A++ IKQF+ L+L + +LELI + P D SR G G++ P Sbjct: 416 YYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPL 475 Query: 490 HDVPVRYRIR 499 +D+ +Y+ + Sbjct: 476 NDIEFKYKFK 485 >4WMZ-A nrPDB Length = 539 Score = 418 bits (1075), Expect = e-117, Method: Composition-based stats. Identities = 96/503 (19%), Positives = 190/503 (37%), Gaps = 45/503 (8%) Query: 17 LLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTV 76 LL S R+ R PPL IPW+G A+ +G F ++K+GDIF+ ++ GR +TV Sbjct: 47 LLYSLRKDR----PPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTV 102 Query: 77 LLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPS----DEKARMKLTLLHRE 132 L P ++ V + A L +F + + P+ ++K +K L Sbjct: 103 YLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEA 162 Query: 133 LQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHES 192 ++ + ++ D+ G +D ++ +T++ E Sbjct: 163 FKSYVPLIAEEVYKYFR-DSKNFRLNERTTGTID----VMVTQPEMTIFTASRSLLGKEM 217 Query: 193 QAQDRVHSA----DVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLAR 248 +A+ A D+ F ++ + P L +DH S + L R Sbjct: 218 RAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRK--RDHAQKAISGTYMSLIKERRKN 275 Query: 249 RAHRSKWLESYLL----HLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPE 304 + + L L+ + + + ++++ A L+ L Q + W+LL L + P+ Sbjct: 276 NDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPD 335 Query: 305 ALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPF-ITREVVV 363 + E +L + L +L P+L+ + E+LR+ + R+V+ Sbjct: 336 VQQELYEEQMRVLDGGK------KELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMK 389 Query: 364 DLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSE------- 416 D+ +P + + G +L+ P + RD E + + F +R+ N S Sbjct: 390 DMHVP---NTSYVIPAGYHVLVSPGYTHLRD-EYFPNAHQFNIHRWNNDSASSYSVGEEV 445 Query: 417 KKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEF 476 F K + + +P+G G + C+G +A + + + + L P Sbjct: 446 DYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPP-- 503 Query: 477 DLSRYGFGLMQPEHDVPVRYRIR 499 + + P + + R Sbjct: 504 --PDFTSMVTLPTGPAKIIWEKR 524 >2WX2-A nrPDB Length = 473 Score = 412 bits (1058), Expect = e-115, Method: Composition-based stats. Identities = 102/481 (21%), Positives = 190/481 (39%), Gaps = 55/481 (11%) Query: 24 TRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK-HGDIFTILVGGRYVTVLLDPHS 82 T RP +PP+ ++P+LG+ + FGK+ F+ R K +FTI +GG+ VT++ DPH Sbjct: 12 TTRPTDPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHE 71 Query: 83 YDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYT 142 + + + PR + +M +F + + +P + R +L L E LT A + Sbjct: 72 H-SRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPY-PRMREQLNFLAEE---LTIAKFQ 126 Query: 143 NLHAVLLGDATE-AGSGWHE----MGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDR 197 N + + + W E + LL+ + ++ L+G + R + Sbjct: 127 NFVPAIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQL 186 Query: 198 VHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRA------- 250 + + + + +P L R L + ++ L K+L +AR Sbjct: 187 L--SKMESSLIPAAVFMPWLLRLPLPQSAR--CREARAELQKILGEIIVAREKEEASKDN 242 Query: 251 HRSKWLESYL--LHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL--KNPEAL 306 + S L L ++ + +S +V ++A Q W +L L+ KN + L Sbjct: 243 NTSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWL 302 Query: 307 AAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLA 366 + E++ Q V+D P + + ES+R + V+ + Sbjct: 303 DKLHKEIDEFPAQLNY---------DNVMDEMPFAERCVRESIRRDPPLLM----VMRMV 349 Query: 367 MPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKR 426 + + +GD + P LS D E F R +P+ EK D Sbjct: 350 KAEVKVGSYVVPKGDIIACSPLLSHH-------DEEAFPNPRLWDPERDEKVD------- 395 Query: 427 LKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLM 486 + +GAG + C+G+ +A+ +K + D +L+ +V P++ G L Sbjct: 396 --GAFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPTLN 453 Query: 487 Q 487 Q Sbjct: 454 Q 454 >5JLC-A nrPDB Length = 515 Score = 409 bits (1051), Expect = e-114, Method: Composition-based stats. Identities = 95/504 (18%), Positives = 193/504 (38%), Gaps = 45/504 (8%) Query: 17 LLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTV 76 LL S R+ R PPL IPW+G A+ +G F ++K+GDIF+ ++ GR +TV Sbjct: 29 LLYSLRKDR----PPLVFYWIPWVGSAIPYGTKPYEFFEDCQKKYGDIFSFMLLGRIMTV 84 Query: 77 LLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPS----DEKARMKLTLLHRE 132 L P ++ + + A L +F + + P+ ++K +K L Sbjct: 85 YLGPKGHEFIFNAKLADVSAEAAYSHLTTPVFGKGVIYDCPNHRLMEQKKFVKGALTKEA 144 Query: 133 LQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHES 192 + ++ + G++D ++ +T++ E Sbjct: 145 FVRYVPLIAEEIYKYFRNSKNFK-INENNSGIVD----VMVSQPEMTIFTASRSLLGKEM 199 Query: 193 QAQDRVHSA----DVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLAR 248 + + A D+ F ++ + P L +DH S + L R + Sbjct: 200 RDKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRK--RDHAQQAISGTYMSLIKERREK 257 Query: 249 RAHRSKWLESYLL----HLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPE 304 +++ L L+ + + ++++ A L+ L Q + W LL L + P+ Sbjct: 258 NDIQNRDLIDELMKNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPD 317 Query: 305 ALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPF-ITREVVV 363 + E +L T L L + P+L+ ++ E+LRL + R+V+ Sbjct: 318 VQEELYQEQMRVLNN------DTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLFRKVMR 371 Query: 364 DLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRF------LNPDGSEK 417 D+A+P + + R +L+ P + ++ E + P F +R+ + G ++ Sbjct: 372 DVAIP---NTSYVVPRDYHVLVSPGYTHLQE-EFFPKPNEFNIHRWDGDAASSSAAGGDE 427 Query: 418 KD--FYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPE 475 D F K + + +P+G G + C+G +A + + + + + E Sbjct: 428 VDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKW---RYPTEGET 484 Query: 476 FDLSRYGFGLMQPEHDVPVRYRIR 499 S + + P + + R Sbjct: 485 VPPSDFTSMVTLPTAPAKIYWEKR 508 >3L4D-A nrPDB Length = 453 Score = 400 bits (1026), Expect = e-112, Method: Composition-based stats. Identities = 98/479 (20%), Positives = 187/479 (39%), Gaps = 56/479 (11%) Query: 26 RPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDA 85 + PP+ G+ P++G+ + FGKD F+ + K+K+G IFT+ + G +TV+ D H + Sbjct: 1 KGKLPPVVHGTTPFVGHIIQFGKDPLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQHSK 60 Query: 86 VVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLH 145 + PR + M +F + + +P + R +L L E LT A + N Sbjct: 61 -FFTPRNEILSPREVYSFMVPVFGEGVAYAAPY-PRMREQLNFLAEE---LTVAKFQNFA 115 Query: 146 AVLLGDATE-AGSGW----HEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHS 200 + + + + W E+ +LD + ++ L+G + R Q + Sbjct: 116 PSIQHEVRKFMKANWNKDEGEINILDDCSAMIINTACQCLFGEDLRKRLDARQFAQLL-- 173 Query: 201 ADVFHTFRQLDRLLPKLARGSLSVGDKDHMC-SVKSRLWKLLSPARLARRA-------HR 252 A + LP + + L + + C ++ L +LS +AR + Sbjct: 174 AKMESCLIPAAVFLPWILKLPLP---QSYRCRDARAELQDILSEIIIAREKEEAQKDTNT 230 Query: 253 SKWLESYL--LHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL--KNPEALAA 308 S L L ++ + +S+ +V ++A Q W LL L+ +N LA Sbjct: 231 SDLLAGLLGAVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAK 290 Query: 309 VRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMP 368 + E++ Q V++ P + ES+R P + +++ + Sbjct: 291 LHQEIDEFPAQLNY---------DNVMEEMPFAEQCARESIR-RDPPLV---MLMRKVLK 337 Query: 369 MADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLK 428 ++ + GD + P LS +D E + +P + R + K + Sbjct: 338 PVQVGKYVVPEGDIIACSPLLS-HQDEEAFPNPREWNPER--------------NMKLVD 382 Query: 429 NYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQ 487 +GAG + C+G + + +K + VL D EL+ + P + G Q Sbjct: 383 GAFCGFGAGVHKCIGEKFGLLQVKTVLATVLRDYDFELL-GPLPEPNYHTMVVGPTASQ 440 >6AYB-A nrPDB Length = 466 Score = 398 bits (1021), Expect = e-111, Method: Composition-based stats. Identities = 91/491 (18%), Positives = 191/491 (38%), Gaps = 44/491 (8%) Query: 19 LSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLL 78 ++++ + + PP IP++G + F K+ F+ +K+GD+FT + G+ +T L Sbjct: 1 MAKKTSSKGKLPPRVPNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFLN 60 Query: 79 DPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTE 138 P D L M +F + + + S E+ ++ + L Sbjct: 61 HPKILDTFFKATDNELSL-RDVYRFMRPVFGTGVVYDADSTERMMEQVKFVSSGLTTARF 119 Query: 139 AMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRV 198 ++ ++ + + + + + ++ L G E E Sbjct: 120 RVFVDIFEDEIAHKVKELGPEGTVDVAELMADLIIFTASRCLLGDEVRQYLSEKNLGKLY 179 Query: 199 HSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLES 258 H D+ L P L K +V +LL R + H + L+ Sbjct: 180 H--DIDDGISPLSFFYPSLPAPKRDKARK----AVGEIFQELLDKRREEHKKHPERLLDE 233 Query: 259 YLL----------HLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAA 308 + + + +++ + L+ L+A Q + W L+ ++ N + L Sbjct: 234 SKMDVVDHLLTQKYKDGQELTDVHRIGILIAGLFAGQHTSSITSSWTLMNVISNKKVLEK 293 Query: 309 VRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMP 368 VR E E I+ L + L++ + E+LR+ + ++ +A Sbjct: 294 VRKEQEEIMGS-------DKVLDYDKVMKMDYLEACMKEALRMYPPLIM----IMRMARK 342 Query: 369 MADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLK 428 + ++ + +G+ L++ P ++ R + YT+P+VF R EK K Sbjct: 343 PRECEQYIIPKGNILVVSPSVA-GRCTDTYTNPDVFDPERLTERKEHEK---------FK 392 Query: 429 NYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQP 488 +P+GAG + C+G ++A+ +K + ++L + D+E I +IP+ Y ++ P Sbjct: 393 YGAVPFGAGRHKCIGENFALLQVKSIISILLRYFDMEYIG---KIPD---PSYTSLVVGP 446 Query: 489 EHDVPVRYRIR 499 +RY++R Sbjct: 447 SPPTRMRYKLR 457 >2X2N-A nrPDB Length = 475 Score = 394 bits (1011), Expect = e-110, Method: Composition-based stats. Identities = 104/493 (21%), Positives = 196/493 (39%), Gaps = 61/493 (12%) Query: 25 RRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK-HGDIFTILVGGRYVTVLLDPHSY 83 RP +PP+ ++P LG+ + FGK F+ K + IFTI + G+ VT++ DPH + Sbjct: 13 TRPTDPPVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEH 72 Query: 84 DAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTN 143 + + PR + M +F + + +P + R +L L E LT A + N Sbjct: 73 -SRFFLPRNEVLSPREVYSFMVPVFGEGVAYAAPY-PRMREQLNFLAEE---LTIAKFQN 127 Query: 144 LHAVLLGDATE-AGSGW----HEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRV 198 + + + + W E+ LL+ + ++ L+G + R + + Sbjct: 128 FVPAIQHEVRKFMAANWDKDEGEINLLEDCSTMIINTACQCLFGEDLRKRLDARRFAQLL 187 Query: 199 HSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARR-------AH 251 A + + LP L + L + H ++ L K+LS +AR+ + Sbjct: 188 --AKMESSLIPAAVFLPILLKLPLPQSARCH--EARTELQKILSEIIIARKAAAVNKDSS 243 Query: 252 RSKWLESYL--LHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLK--NPEALA 307 S L L ++ + +S +V ++A Q W +L L+ N + L Sbjct: 244 TSDLLSGLLSAVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLE 303 Query: 308 AVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPF-ITREVVVDLA 366 A+R E+E Q V+D P + ES+R + R+V+ D+ Sbjct: 304 ALRKEIEEFPAQLNY---------NNVMDEMPFAERCARESIRRDPPLLMLMRKVMADVK 354 Query: 367 MPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKR 426 + + + +GD + P LS D E + +P + R ++ Sbjct: 355 V-----GSYVVPKGDIIACSPLLS-HHDEEAFPEPRRWDPER---------------DEK 393 Query: 427 LKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLM 486 ++ + +GAG + C+G+ + + +K + D +L+ +V P++ G Sbjct: 394 VEGAFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQLLRDEVPDPDYHTMVVGPTAS 453 Query: 487 QPEHDVPVRYRIR 499 Q V+Y R Sbjct: 454 Q----CRVKYIRR 462 >3JUS-A nrPDB Length = 461 Score = 393 bits (1008), Expect = e-109, Method: Composition-based stats. Identities = 101/482 (20%), Positives = 190/482 (39%), Gaps = 49/482 (10%) Query: 28 GEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVV 87 PP IP+LG+A+ FGK FL EK+G +F+ + G+ T LL + + Sbjct: 11 KSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLF 70 Query: 88 WEPRTRLDFHAYAIFLMERIFDVQLPHYSPS----DEKARMKLTLLHRELQALTEAMYTN 143 L+ L +F + + P+ ++K +K L A + Sbjct: 71 NSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLK--------SGLNIAHFKQ 122 Query: 144 LHAVLLGDATEAGSGWHEMG---LLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHS 200 +++ + E W E G + + ++ L+G E + +E AQ Sbjct: 123 HVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQ---LY 179 Query: 201 ADVFHTFRQLDRLLP-KLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESY 259 AD+ F LLP L S D+ H +K +K + R ++ L++ Sbjct: 180 ADLDGGFSHAAWLLPGWLPLPSFRRRDRAHR-EIKDIFYKAIQKRRQSQEK-IDDILQTL 237 Query: 260 LL--HLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESIL 317 L + + ++++ A L+ L A Q + W+ FL ++ E +++ Sbjct: 238 LDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVC 297 Query: 318 WQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNL 377 + P L L +LD + E+LRL I ++ +A + + Sbjct: 298 GENLPP------LTYDQLKDLNLLDRCIKETLRLRPPIMI----MMRMARTPQTVAGYTI 347 Query: 378 RRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAG 437 G ++ + P ++ QR + + + F +R+L + + + F +P+GAG Sbjct: 348 PPGHQVCVSPTVN-QRLKDSWVERLDFNPDRYLQDNPASGEKF---------AYVPFGAG 397 Query: 438 HNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYR 497 + C+G ++A IK +L + +LI+ F Y + PE+ V +RY+ Sbjct: 398 RHRCIGENFAYVQIKTIWSTMLRLYEFDLIDG-----YFPTVNYTTMIHTPENPV-IRYK 451 Query: 498 IR 499 R Sbjct: 452 RR 453 >6CR2-A nrPDB Length = 477 Score = 385 bits (988), Expect = e-107, Method: Composition-based stats. Identities = 91/490 (18%), Positives = 179/490 (36%), Gaps = 39/490 (7%) Query: 28 GEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVV 87 PP+ P++G + +G D F + K+GDIFT ++ G+ TV L D ++ Sbjct: 4 KTPPVVFHWFPFIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGNDFIL 63 Query: 88 WEPRTRLDFHAYAIFLMERIFD----VQLPHYSPSDEKARMKLTLLHRELQALTEAMYTN 143 + L +F P+ ++K +K L L++ + Sbjct: 64 NGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKYGLTSDALRSYVPLITDE 123 Query: 144 LHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADV 203 + + + G G+ D + +T+Y + E +++ A++ Sbjct: 124 VESFVKNSPAFQG----HKGVFDVCKTI----AEITIYTASRSLQGKEVRSKFDSTFAEL 175 Query: 204 FH----TFRQLDRLLPK--LARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLE 257 +H F ++ +LP L + + + K A + + W Sbjct: 176 YHNLDMGFAPINFMLPWAPLPHNRKRDAAQRKLTETYMEIIKARRQAGSKKDSEDMVWNL 235 Query: 258 SYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESIL 317 ++ V +E A ++ L A Q + A W++L L P+ + + E +L Sbjct: 236 MSCVYKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVL 295 Query: 318 WQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMA-DGREFN 376 P L L + V+ E+LRL A ++ + PMA DG + Sbjct: 296 GSDLPP------LTYDNLQKLDLHAKVIKETLRLHAP---IHSIIRAVKNPMAVDGTSYV 346 Query: 377 LRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRF-----LNPDGSEKKDFYK--DGKRLKN 429 + +L P ++ R E + +P + +R+ + + EK D+ K + Sbjct: 347 IPTSHNVLSSPGVTA-RSEEHFPNPLEWNPHRWDENIAASAEDDEKVDYGYGLVSKGTNS 405 Query: 430 YNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPE 489 +P+GAG + C+G +A + +++ + IP+ D Y +P Sbjct: 406 PYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPGVDGIPDTD---YSSLFSKPL 462 Query: 490 HDVPVRYRIR 499 V + R Sbjct: 463 GRSFVEFEKR 472 >5FSA-A nrPDB Length = 490 Score = 361 bits (927), Expect = e-100, Method: Composition-based stats. Identities = 90/496 (18%), Positives = 185/496 (37%), Gaps = 42/496 (8%) Query: 28 GEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVV 87 PPL IPW G A +G+ F ++K+GD+F+ ++ G+ +TV L P ++ V Sbjct: 4 KTPPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVF 63 Query: 88 WEPRTRLDFHAYAIFLMERIFDVQLPHYSPS----DEKARMKLTLLHRELQALTEAMYTN 143 + + L +F + + P+ ++K K L + + Sbjct: 64 NAKLSDVSAEEAYKHLTTPVFGTGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREE 123 Query: 144 LHAVLLGDATEAGSGWHEMGLLDFSYS---FLLRAGYLTLYGIEALPRTHESQAQDRVHS 200 + + D G+ + + + +L+G E S AQ Sbjct: 124 ILNYFVTD-ESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQ---LY 179 Query: 201 ADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHR--SKWLES 258 +D+ F ++ + P L +D S + R R ++S Sbjct: 180 SDLDKGFTPINFVFPNLPLPHY--WRRDAAQKKISATYMKEIKLRRERGDIDPNRDLIDS 237 Query: 259 YLL---HLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELES 315 L+ + + + ++++ A L+ L Q + W LL L + P + E+ Sbjct: 238 LLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVE 297 Query: 316 ILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPF-ITREVVVDLAMPMADGRE 374 +L ++ L + L P +++ + E+LR+ I R+V L +P Sbjct: 298 LL---KEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPE---TN 351 Query: 375 FNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNP---------DGSEKKD--FYKD 423 + + +G +L+ P + + + +PE F R+ + S++ D F K Sbjct: 352 YIVPKGHYVLVSPGYAHTSE-RYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKV 410 Query: 424 GKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGF 483 K + + +P+G G + C+G +A + + + +L + V P+ Y Sbjct: 411 SKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPD-----YSS 465 Query: 484 GLMQPEHDVPVRYRIR 499 ++ P + + R Sbjct: 466 MVVLPTEPAEIIWEKR 481 >2W0A-A nrPDB Length = 455 Score = 346 bits (887), Expect = 1e-95, Method: Composition-based stats. Identities = 106/479 (22%), Positives = 180/479 (37%), Gaps = 47/479 (9%) Query: 31 PLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEP 90 P G G+ +F D + R++++ GD+ T + G+ V +L H+ + Sbjct: 7 PRVSGGHDEHGHLEEFRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHANEFFFRAG 66 Query: 91 RTRLDFHAYAIFLMERIFDV-QLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLL 149 LD A A M IF + SP K + L E A + ++ Sbjct: 67 DDDLD-QAKAYPFMTPIFGEAVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQVRRMI 125 Query: 150 GDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQ 209 D EAG E+ LLDF + L G + + A+ ++ Sbjct: 126 ADWGEAG----EIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAK---LYHELERGTDP 178 Query: 210 LDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHR------SKWLESYLLHL 263 L + P L S D ++ L L++ R A+ L+ + Sbjct: 179 LAYVDPYLPIESFRRRD-----EARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVK 233 Query: 264 EEMGVS---EEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQA 320 E G + + ++A A W L+ L+++ +A AAV EL+ + Sbjct: 234 AETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDG 293 Query: 321 EQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRG 380 ++ L P L++VL E+LRL I ++ +A + + + G Sbjct: 294 R-------SVSFHALRQIPQLENVLKETLRLHPPLII----LMRVAKGEFEVQGHRIHEG 342 Query: 381 DRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNH 440 D + P +S R PE + DP F R+ P ++ + +P+GAG + Sbjct: 343 DLVAASPAIS-NRIPEDFPDPHDFVPARYEQPR--------QEDLLNRWTWIPFGAGRHR 393 Query: 441 CLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 499 C+G ++A+ IK ++L + E+ E D S+ L QP VRYR R Sbjct: 394 CVGAAFAIMQIKAIFSVLLREYEFEMAQPP-ESYRNDHSKMVVQLAQPA---AVRYRRR 448 >5E0E-A nrPDB Length = 463 Score = 231 bits (589), Expect = 5e-61, Method: Composition-based stats. Identities = 90/472 (19%), Positives = 174/472 (36%), Gaps = 67/472 (14%) Query: 54 LTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIF-DVQL 112 R++EK+GD+FT+ +G R V +L + + + + I ++E IF + Sbjct: 27 FRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVD-QAEAFSGRGTIAVVEPIFRGYGV 85 Query: 113 PHYSPSDEKARMKLTLL-----HRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDF 167 + KA + +L+ +++ E + ++ G+ L Sbjct: 86 VFANGERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEFRKSQGAPLDPTFLFQC 145 Query: 168 SYSFLLRAGYLTLYGIEALPRTHE----------SQAQDRVHSADVFHTFRQLDRLLPKL 217 + ++ ++G + H+ S + S+ VF F + P Sbjct: 146 ITANII---CSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFSGFLKYFPGT 202 Query: 218 ARGSLSVGDK--DHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSE--EMQ 273 R + D++ + L P +H ++++YLL +E+ ++ E Sbjct: 203 HRQISRNLQEILDYIGQSVEKHRATLDP------SHPRDFIDTYLLRMEKEKSNQHTEFD 256 Query: 274 ARALVLQL----WATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTT 329 + LV+ + +A + L +LK P V+ E++ ++ P + T Sbjct: 257 HQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLEDRT 316 Query: 330 LPQKVLDSTPVLDSVLSESLRLTA--APFITREVVVDLAMPMADGREFNLRRGDRLLLFP 387 P ++V+ E R + + +V D R + L + + +P Sbjct: 317 -------KMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLF-----RGYLLPKNTEV--YP 362 Query: 388 FLSP-QRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSY 446 LS DP+ + P+ F + FL+ +G+ KK MP+ G CLG Sbjct: 363 ILSSALHDPQYFEQPDTFNPDHFLDANGALKKS---------EAFMPFSIGKRICLGEGI 413 Query: 447 AVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRI 498 A N + F +L + L + V + DLS G VP Y+I Sbjct: 414 ARNELFLFFTTILQNFSLS---SPVAPKDIDLSPKESGF----GKVPQTYQI 458 >4H1N-A nrPDB Length = 479 Score = 231 bits (588), Expect = 6e-61, Method: Composition-based stats. Identities = 95/508 (18%), Positives = 180/508 (35%), Gaps = 67/508 (13%) Query: 19 LSRRRTRRPGEPPLDLGSIPWLGYALDF-GKDAASFLTRMKEKHGDIFTILVGGRYVTVL 77 ++++ + + PP +P LG L K R++EK+GD+FT+ +G R V VL Sbjct: 1 MAKKTSSKGKLPP-GPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVL 59 Query: 78 LDPHSYDAVVWEPRTRLDFHAYAIFLMERIF-DVQLPHYSPSDEKARMKLTLL-----HR 131 + + + + I +++ IF + + +A + +L Sbjct: 60 CGTDAIREALVD-QAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFSLATMRDFGM 118 Query: 132 ELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRT-- 189 +++ E + ++ G+ L +S ++G + Sbjct: 119 GKRSVEERIQEEARCLVEELRKSKGALLDNTLLF---HSITSNIICSIVFGKRFDYKDPV 175 Query: 190 --------HESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLL 241 +S + S+ VF F + P R ++ + + + + + Sbjct: 176 FLRLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYR-----NLQEINTFIGQSV 230 Query: 242 SPARLARRA-HRSKWLESYLLHLEEMGVS--EEMQARALVLQLW----ATQGNMGPAAFW 294 R + +++ YLL +E+ E + L+L + A + Sbjct: 231 EKHRATLDPSNPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRY 290 Query: 295 LLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTA- 353 L +LK P V+ E+E ++ P P D+V+ E RL Sbjct: 291 GFLLMLKYPHVTERVQKEIEQVIGSHRPPALDDRA-------KMPYTDAVIHEIQRLGDL 343 Query: 354 APF-ITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSP-QRDPEIYTDPEVFKYNRFLN 411 PF + V D R + + + + FP LS DP + P F FL+ Sbjct: 344 IPFGVPHTVTKDTQF-----RGYVIPKNTEV--FPVLSSALHDPRYFETPNTFNPGHFLD 396 Query: 412 PDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADV 471 +G+ K++ MP+ G CLG A + F +L + I + V Sbjct: 397 ANGALKRN---------EGFMPFSLGKRICLGEGIARTELFLFFTTILQNFS---IASPV 444 Query: 472 EIPEFDLSRYGFGLMQPEHDVPVRYRIR 499 + DL+ G+ +VP Y+IR Sbjct: 445 PPEDIDLTPRESGV----GNVPPSYQIR 468 >6DWN-A nrPDB Length = 491 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 77/480 (16%), Positives = 167/480 (34%), Gaps = 57/480 (11%) Query: 19 LSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLL 78 ++++ + + + P P +G+ L GK+ L+RM +++GD+ I +G V VL Sbjct: 1 MAKKTSSKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLS 60 Query: 79 DPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE-----KARMKLTLLHREL 133 + + + S + + L + Sbjct: 61 GLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSI 120 Query: 134 QA--------LTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGI-- 183 + E + VL+ E +G + + +G Sbjct: 121 ASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRY 180 Query: 184 EALPRTHESQAQDRVHSADVFHTFRQLDRL--LPKLARGSLSVGDKDHMCSVKSRLWKLL 241 + + S + +V + D + L L SL+ + + + + Sbjct: 181 DHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFK-----DLNEKFYSFM 235 Query: 242 SPARLAR-----RAHRSKWLESYLLHLEEMGVSEEMQAR-------ALVLQLW-ATQGNM 288 + H +S + H +E + E + +VL L+ A + Sbjct: 236 QKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTV 295 Query: 289 GPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSES 348 A W L++L+ NP ++ EL++++ ++ +P + P +++ + E+ Sbjct: 296 TTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS-------HLPYMEAFILET 348 Query: 349 LRLTA-APF-ITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKY 406 R ++ PF I D ++ + F + +G R + D +++ +P F Sbjct: 349 FRHSSFVPFTIPHSTTRDTSL-----KGFYIPKG-RCVFVNQWQINHDQKLWVNPSEFLP 402 Query: 407 NRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLEL 466 RFL PDG K L + +G G C+G + A + F+ ++L ++ + Sbjct: 403 ERFLTPDG-------AIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSV 455 >5E58-A nrPDB Length = 493 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 81/468 (17%), Positives = 167/468 (35%), Gaps = 59/468 (12%) Query: 54 LTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFD-VQL 112 R++EK+GD+FT+ +G R V +L + + + + I +++ + + Sbjct: 55 FMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVD-QAEAFSGRGTIAVIKPVIGDYGM 113 Query: 113 PHYSPSDEKARMKLTLL-----HRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDF 167 + K + +L +++ + + ++ G+ L Sbjct: 114 IFSNGERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVEELQKSQGAPLDPTFLFQC 173 Query: 168 SYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDK 227 + ++ ++G E + F + +L G + Sbjct: 174 ITANII---CSIVFG-ERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFSGFMKYFPG 229 Query: 228 DHMCSVKSRLWKLLSPARLARRAH--------RSKWLESYLLHLEEMGVSE--EMQARAL 277 H ++ L ++L + H ++++YLL +E+ ++ E + L Sbjct: 230 AHRQITRN-LQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSNQHTEFHHQNL 288 Query: 278 VLQL----WATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQK 333 ++ + +A + L +LK P V+ E++ ++ P + T Sbjct: 289 LISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLEDRT---- 344 Query: 334 VLDSTPVLDSVLSESLRLTAAPFI--TREVVVDLAMPMADGREFNLRRGDRLLLFPFLSP 391 P D+V+ E R + I +V D R + L + + +P LS Sbjct: 345 ---KMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLF-----RGYLLPKNTEV--YPILSS 394 Query: 392 -QRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNS 450 DP+ + P F + FL+ +G+ KK MP+ G CLG A N Sbjct: 395 ALHDPQYFEQPGTFNPDHFLDANGALKKS---------EAFMPFSIGKRICLGEGIARNE 445 Query: 451 IKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRI 498 + F +L + +++ V + DLS G+ VP Y+I Sbjct: 446 LFLFFTTILQNFS---VSSSVAPKDIDLSPKESGI----GKVPQTYQI 486 >6DA2-A nrPDB Length = 487 Score = 226 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 80/485 (16%), Positives = 179/485 (36%), Gaps = 48/485 (9%) Query: 34 LGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTR 93 +P+LG L + K F +K+G ++ G + V + DP V+ + Sbjct: 21 PTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYS 80 Query: 94 LDFHAYAIFLMERIFDVQLPHYSPSDEKARMKL----TLLHRELQALTEAMYTNLHAVLL 149 + + F + +E R++ T +L+ + + ++ Sbjct: 81 VFTNR--RPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVR 138 Query: 150 GDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEA----LPRTHESQAQDRVHSADVFH 205 EA +G + L D ++ + T +G+ P+ + ++ D Sbjct: 139 NLRREAETGKP-VTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLD 197 Query: 206 TF----RQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLL 261 F L+P L ++ V ++ ++ + ++ + HR +L+ + Sbjct: 198 PFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMID 257 Query: 262 HLEEMGV-------SEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELE 314 E+ A++++ ++A +++ L +P+ ++ E++ Sbjct: 258 SQNSKETESHKALSDLELVAQSIIF-IFAGYETTSSVLSFIMYELATHPDVQQKLQEEID 316 Query: 315 SILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGRE 374 ++L P + LD V++E+LRL + + + Sbjct: 317 AVLPNKAPPTYD-------TVLQMEYLDMVVNETLRLFPIAMR----LERVCKKDVEING 365 Query: 375 FNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPW 434 + +G +++ P + RDP+ +T+PE F RF + P+ Sbjct: 366 MFIPKG-VVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN---------IDPYIYTPF 415 Query: 435 GAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPV 494 G+G +C+G +A+ ++K + VL + + + +IP L GL+QPE V + Sbjct: 416 GSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCK-ETQIP---LKLSLGGLLQPEKPVVL 471 Query: 495 RYRIR 499 + R Sbjct: 472 KVESR 476 >6B82-A nrPDB Length = 509 Score = 223 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 73/491 (14%), Positives = 167/491 (34%), Gaps = 47/491 (9%) Query: 30 PPLDLGSIPWLGYALDFGKD--AASFLTRMKEKHGDIFTILVGGRYVTVLLDPH-SYDAV 86 PP P +G + D F +++K+GD++++++G + ++ + H + + + Sbjct: 25 PPSLPSL-PIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHHHAKEIL 83 Query: 87 VWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSD----EKARMKLTLLHRELQALTEAMYT 142 + + + + + S + + L +++ Sbjct: 84 IKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGEGSVSIEKII 143 Query: 143 NLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSAD 202 A + + + L + + E ++ + Sbjct: 144 CREASSMCEVLTESQN-SAVDLGPELTRAVTNVVCALCFNSSYKRGDAEFESMLQYSQGI 202 Query: 203 VFHTFR-QLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARR-----AHRSKWL 256 V + L + P L D + S KLL + + L Sbjct: 203 VDTVAKDSLVDIFPWLQI--FPNKDLRILRQCISIRDKLLQKKYEEHKVTYSDNVQRDLL 260 Query: 257 ESYLLHLEEMGVS---------EEMQARALVLQLW-ATQGNMGPAAFWLLLFLLKNPEAL 306 ++ L + E V +++ A W + +L+ NP+ Sbjct: 261 DALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTTLKWSIAYLVHNPQVQ 320 Query: 307 AAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLA 366 ++ EL+S + + P + P L++ + E +R+ + ++ +A Sbjct: 321 RKIQEELDSKIGKERHPQLSDR-------GNLPYLEATICEVMRIRPVSPL---LIPHVA 370 Query: 367 MPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKR 426 + + E+ +++G R+++ S D + + +PE+F RFLN +G Sbjct: 371 LQDSSVGEYTVQKGTRVVIN-MWSLHHDEKEWKNPELFDPGRFLNEEGD-------GLCC 422 Query: 427 LKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLM 486 +P+GAG CLG + A + F+ +L LE+ +P+ ++G L Sbjct: 423 PSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQ-PLPDLQ-GKFGVVLQ 480 Query: 487 QPEHDVPVRYR 497 + V + R Sbjct: 481 PKKFKVVAKVR 491 >2PG7-A nrPDB Length = 476 Score = 223 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 85/511 (16%), Positives = 180/511 (35%), Gaps = 69/511 (13%) Query: 19 LSRRRTRRPGEPPLDLGSIPWLGYALDFGKDA-ASFLTRMKEKHGDIFTILVGGRYVTVL 77 ++++ + + PP +P++G L + + L ++ E++G +FTI +G R V VL Sbjct: 1 MAKKTSSKGKLPP-GPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVL 59 Query: 78 LDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLL-----HRE 132 + + + + + K + ++ Sbjct: 60 CGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVG 119 Query: 133 LQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHES 192 + + E + ++ G+ + F + ++G + E Sbjct: 120 KRGIEERIQEEAGFLIDALRGTGGAN---IDPTFFLSRTVSNVISSIVFGDRFDYKDKEF 176 Query: 193 QAQDRV----------HSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLS 242 + R+ + ++ F + + LP G + + L ++ Sbjct: 177 LSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLP---------GPQQQAFQLLQGLEDFIA 227 Query: 243 PARLARR-----AHRSKWLESYLLHLEEM--GVSEEMQARALV---LQLW-ATQGNMGPA 291 + +++S+L+ ++E + E + LV LQL+ + Sbjct: 228 KKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTT 287 Query: 292 AFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL 351 + L L+K+PE A V E++ ++ + QP + P +++V+ E R Sbjct: 288 LRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRA-------KMPYMEAVIHEIQRF 340 Query: 352 -TAAPF-ITREVVVDLAMPMADGREFNLRRGDRLLLFPFL-SPQRDPEIYTDPEVFKYNR 408 P + R V D R+F L +G + +P L S RDP +++P+ F Sbjct: 341 GDVIPMSLARRVKKDTKF-----RDFFLPKGTEV--YPMLGSVLRDPSFFSNPQDFNPQH 393 Query: 409 FLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELIN 468 FLN G KK + +P+ G +C G A + F V+ + L+ Sbjct: 394 FLNEKGQFKKS---------DAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK--- 441 Query: 469 ADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 499 + + D+S G + + + R Sbjct: 442 SSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 472 >1N6B-A nrPDB Length = 473 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 93/501 (18%), Positives = 186/501 (37%), Gaps = 58/501 (11%) Query: 19 LSRRRTRRPGEPPLDLGSIPWLGYALDF-GKDAASFLTRMKEKHGDIFTILVGGRYVTVL 77 ++++ + + PP P +G L KD + LT+ E +G +FT+ +G + VL Sbjct: 1 MAKKTSSKGKLPP-GPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVL 59 Query: 78 LDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLL-----HRE 132 + + + L + + + + K + +L+ Sbjct: 60 HGYEAVKEALVDLGEEFAGRGSVPILEKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMG 119 Query: 133 LQALTEAMYTNLHAVLLGDATEAGSGWHEMGLL-----DFSYSFLL--RAGYLTLYGIEA 185 +++ + + ++ S +L + S + R Y ++ Sbjct: 120 KRSIEDRIQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKL 179 Query: 186 LPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGD--KDHMCSVKSRLWKLLSP 243 + HE+ V++ F L P + + L D K+ + KLL Sbjct: 180 MESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLD- 238 Query: 244 ARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQ---LW-ATQGNMGPAAFWLLLFL 299 + +++ +L+ +E+ + E +LV+ L+ A + LL L Sbjct: 239 -----VNNPRDFIDCFLIKMEQEN-NLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLL 292 Query: 300 LKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTA--APFI 357 LK+PE A V+ E+E ++ + P Q + P D+V+ E R + Sbjct: 293 LKHPEVAARVQEEIERVIGRHRSPCMQDRSR-------MPYTDAVIHEIQRFIDLLPTNL 345 Query: 358 TREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEK 417 V D+ R + + +G ++ S D + + +P+VF FL+ G+ K Sbjct: 346 PHAVTRDVRF-----RNYFIPKGTDIITS-LTSVLHDEKAFPNPKVFDPGHFLDESGNFK 399 Query: 418 KDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFD 477 K +Y MP+ AG C+G A + F+ +L + L + VE + D Sbjct: 400 KS---------DYFMPFSAGKRMCVGEGLARMELFLFLTSILQNFKL---QSLVEPKDLD 447 Query: 478 LSRYGFGLMQPEHDVPVRYRI 498 ++ G + VP Y++ Sbjct: 448 ITAVVNGFVS----VPPSYQL 464 >3E6I-A nrPDB Length = 476 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 79/498 (15%), Positives = 162/498 (32%), Gaps = 52/498 (10%) Query: 19 LSRRRTRRPGEPPLDLGSIPWLGYALDFG-KDAASFLTRMKEKHGDIFTILVGGRYVTVL 77 ++++ + + PP +P +G K+ TR+ ++ G +FT+ VG + + V+ Sbjct: 1 MAKKTSSKGKLPP-GPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVM 59 Query: 78 LDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALT 137 + + + + + + P+ + R L+ Sbjct: 60 HGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIR---RFSLTTLRNYG 116 Query: 138 EAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPR----THESQ 193 N + + +A + F +FL+ + + E Sbjct: 117 MGKQGN-ESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKF 175 Query: 194 AQDRVHSADVFHTF-RQLDRLLPKLAR-GSLSVGDKDHMCSVKSRLWKLLSPARLARRAH 251 + + FH +L G + + + + +S Sbjct: 176 LRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQS 235 Query: 252 -----RSKWLESYLLHLEEMGVSEEM------QARALVLQLWATQGNMGPAAFWLLLFLL 300 + L+ +E+ S E + +A + LL L+ Sbjct: 236 LDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILM 295 Query: 301 KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLT--AAPFIT 358 K PE + E++ ++ + P + P +D+V+ E R + Sbjct: 296 KYPEIEEKLHEEIDRVIGPSRIPAIKDR-------QEMPYMDAVVHEIQRFITLVPSNLP 348 Query: 359 REVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKK 418 E D R + + +G +++ S D + + DPE FK FLN +G K Sbjct: 349 HEATRDTIF-----RGYLIPKGT-VVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKY 402 Query: 419 DFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDL 478 +Y P+ G C G A + + +L H +L+ + V+ + DL Sbjct: 403 S---------DYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL---VDPKDIDL 450 Query: 479 SR--YGFGLMQPEHDVPV 494 S GFG + P + + V Sbjct: 451 SPIHIGFGCIPPRYKLCV 468 >5VEU-A nrPDB Length = 480 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 87/486 (17%), Positives = 184/486 (37%), Gaps = 51/486 (10%) Query: 34 LGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTR 93 +P LG L + + F T +K+G ++ G V + DP V+ + Sbjct: 20 PTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYS 79 Query: 94 LDFHAYAIFLMERIFDVQLPHYSPSDEKARMKL----TLLHRELQALTEAMYTNLHAVLL 149 + + L F + +E R++ T +L+ + + ++ Sbjct: 80 VFTNR--RSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVR 137 Query: 150 GDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEA----LPRTHESQAQDRVH---SAD 202 EA G + L D ++ + T +G+ P+ ++ + D Sbjct: 138 NLRREAEKGKP-VTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLD 196 Query: 203 -VFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLL 261 +F + L P ++S+ KD + + + ++ ++ HR +L+ + Sbjct: 197 PLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMID 256 Query: 262 HLEEMGV-------SEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELE 314 E+ A++++ ++A + L L +P+ ++ E++ Sbjct: 257 SQNSKETESHKALSDLELAAQSIIF-IFAGYETTSSVLSFTLYELATHPDVQQKLQKEID 315 Query: 315 SILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPF-ITREVVVDLAMPMADGR 373 ++L P + LD V++E+LRL + R D+ + Sbjct: 316 AVLPNKAPPTYD-------AVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI-----N 363 Query: 374 EFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMP 433 + +G +++ P + DP+ +T+PE F+ RF S+KKD P Sbjct: 364 GVFIPKGSMVVI-PTYALHHDPKYWTEPEEFRPERF-----SKKKD-----SIDPYIYTP 412 Query: 434 WGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVP 493 +G G +C+G +A+ ++K + VL + + + +IP L GL+QPE + Sbjct: 413 FGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCK-ETQIP---LKLDTQGLLQPEKPIV 468 Query: 494 VRYRIR 499 ++ R Sbjct: 469 LKVDSR 474 >5W0C-A nrPDB Length = 477 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 94/504 (18%), Positives = 185/504 (36%), Gaps = 60/504 (11%) Query: 19 LSRRRTRRPGEPPLDLGSIPWLGYALDFG-KDAASFLTRMKEKHGDIFTILVGGRYVTVL 77 ++++ + G+ P +P +G L G KD + LT + + +G +FT+ G + + VL Sbjct: 1 MAKKTSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVL 60 Query: 78 LDPHSYDAV--VWEPRTRLDFHAYAIFLMERI---FDVQLPHYSPSDEKARMKLTLLHR- 131 H Y+AV L ER F + + E R L L Sbjct: 61 ---HGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNF 117 Query: 132 --ELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLL-----DFSYSFLL--RAGYLTLYG 182 +++ + + ++ S +L + S + R Y Sbjct: 118 GMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQF 177 Query: 183 IEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLS 242 + + + +E+ + + F + P G+ + K+ L K+ Sbjct: 178 LNLMEKLNENIKILSSPWIQICNNFSPIIDYFP----GTHNKLLKNVAFMKSYILEKVKE 233 Query: 243 PARLARRAHRSKWLESYLLHLEEMGVSEE-----MQARALVLQLW-ATQGNMGPAAFWLL 296 + +++ +L+ +E+ ++ + L+ A + L Sbjct: 234 HQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYAL 293 Query: 297 LFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTA--A 354 L LLK+PE A V+ E+E ++ + P Q + P D+V+ E R Sbjct: 294 LLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRS-------HMPYTDAVVHEVQRYIDLLP 346 Query: 355 PFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDG 414 + V D+ R + + +G +L+ S D + + +PE+F + FL+ G Sbjct: 347 TSLPHAVTCDIKF-----RNYLIPKGTTILIS-LTSVLHDNKEFPNPEMFDPHHFLDEGG 400 Query: 415 SEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIP 474 + KK Y MP+ AG C+G + A + F+ +L + +L+ + V+ Sbjct: 401 NFKKS---------KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLK---SLVDPK 448 Query: 475 EFDLSRYGFGLMQPEHDVPVRYRI 498 D + G VP Y++ Sbjct: 449 NLDTTPVVNGFAS----VPPFYQL 468 >4GQS-A nrPDB Length = 477 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 87/504 (17%), Positives = 172/504 (34%), Gaps = 60/504 (11%) Query: 19 LSRRRTRRPGEPPLDLGSIPWLGYALDFG-KDAASFLTRMKEKHGDIFTILVGGRYVTVL 77 ++++ + G+ P +P +G L KD + LT + + +G +FT+ G + VL Sbjct: 1 MAKKTSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVL 60 Query: 78 LDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLL-----HRE 132 + + + + + K + +L+ Sbjct: 61 HGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMG 120 Query: 133 LQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHES 192 +++ + + ++ S L A + I R Sbjct: 121 KRSIEDRVQEEARCLVEELRKTKASPCDPT-------FILGCAPCNVICSIIFQKRFDYK 173 Query: 193 QAQDRVHSADVFHTFR-------QLDRLLPKLA---RGSLSVGDKDHMCSVKSRLWKLLS 242 Q + R Q+ P + G+ + K+ L K+ Sbjct: 174 DQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKE 233 Query: 243 PARLARRAHRSKWLESYLLHLEEMGVSE--EMQARALVL----QLWATQGNMGPAAFWLL 296 + +++ +L+ +E+ ++ E LV+ L A + L Sbjct: 234 HQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYAL 293 Query: 297 LFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTA--A 354 L LLK+PE A V+ E+E ++ + P Q P D+V+ E R Sbjct: 294 LLLLKHPEVTAKVQEEIERVVGRNRSPCMQDR-------GHMPYTDAVVHEVQRYIDLIP 346 Query: 355 PFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDG 414 + V D+ R + + +G +L S D + + +PE+F FL+ G Sbjct: 347 TSLPHAVTCDVKF-----RNYLIPKGTTILTS-LTSVLHDNKEFPNPEMFDPRHFLDEGG 400 Query: 415 SEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIP 474 + KK NY MP+ AG C+G A + F+ +L + +L+ + ++ Sbjct: 401 NFKKS---------NYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLK---SLIDPK 448 Query: 475 EFDLSRYGFGLMQPEHDVPVRYRI 498 + D + G VP Y++ Sbjct: 449 DLDTTPVVNGFAS----VPPFYQL 468 >3IBD-A nrPDB Length = 476 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 75/471 (15%), Positives = 155/471 (32%), Gaps = 57/471 (12%) Query: 51 ASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIF-D 109 R +EK+GD+FT+ +G R V +L + + + + I +++ F Sbjct: 33 LKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVD-KAEAFSGRGKIAMVDPFFRG 91 Query: 110 VQLPHYSPSDEKARMKLTLL-----HRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGL 164 + + + K + ++ +++ E + ++ G+ L Sbjct: 92 YGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFL 151 Query: 165 LDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKL--ARGSL 222 S ++G R H + + TF + + +L Sbjct: 152 FQ---SITANIICSIVFG----KRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGF 204 Query: 223 SVGDKDHMCSVKSRLWKLLSPARLARRAH--------RSKWLESYLLHLEEMGVSE--EM 272 V L ++ + + H +++YLLH+E+ + E Sbjct: 205 LKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSNAHSEF 264 Query: 273 QARAL----VLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTT 328 + L + +A + L +LK P V E+E ++ P Sbjct: 265 SHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDR 324 Query: 329 TLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPF 388 P ++V+ E R + + V + R + + + + L Sbjct: 325 A-------KMPYTEAVIYEIQRFSDLLPMG---VPHIVTQHTSFRGYIIPKDTEVFLI-L 373 Query: 389 LSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAV 448 + DP + P+ F + FL+ +G+ KK +P+ G CLG A Sbjct: 374 STALHDPHYFEKPDAFNPDHFLDANGALKKT---------EAFIPFSLGKRICLGEGIAR 424 Query: 449 NSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 499 + F +L + + + V + DL+ G+ +P Y+IR Sbjct: 425 AELFLFFTTILQNFSM---ASPVAPEDIDLTPQECGV----GKIPPTYQIR 468 >3EL3-A nrPDB Length = 467 Score = 207 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 76/452 (16%), Positives = 151/452 (33%), Gaps = 41/452 (9%) Query: 29 EPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVW 88 EPP+ G +P LG+ +D +F++++++ HGD+ I +G + V + +P A+ Sbjct: 23 EPPVAGGGVPLLGHGWRLARDPLAFMSQLRD-HGDVVRIKLGPKTVYAVTNPELTGALAL 81 Query: 89 EPRTRLDFHAYAIFLMERIFDVQLPHYS---PSDEKARMKLTLLHRELQALTEAMYTNLH 145 P + L + + + ++ ++ + A M Sbjct: 82 NPDYHIAGPL-WESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEE-- 138 Query: 146 AVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFH 205 TE + S+ +R L E + V A VF Sbjct: 139 ---AHALTERWQPGKTVDATSESFRVAVRVAARCLL---RGQYMDERAERLCVALATVFR 192 Query: 206 TFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAH---RSKWLESYLLH 262 + ++P L + + L L+ RRA L + L Sbjct: 193 GMYR-RMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEA 251 Query: 263 LE--EMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQA 320 + + E+ +V L + WLL L +PE +R E+E++ Sbjct: 252 KDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG-- 309 Query: 321 EQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRG 380 + + + +V+ E++RL A V+ A+ ++ + + G Sbjct: 310 ------GRPVAFEDVRKLRHTGNVIVEAMRLRPA----VWVLTRRAVAESELGGYRIPAG 359 Query: 381 DRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNH 440 ++ P + QRDP+ Y D F +R+L + K P+ AG Sbjct: 360 ADIIYSP-YAIQRDPKSYDDNLEFDPDRWLPERAAN---------VPKYAMKPFSAGKRK 409 Query: 441 CLGRSYAVNSIKQFVFLVLVHLDLELINADVE 472 C +++ + + E + + Sbjct: 410 CPSDHFSMAQLTLITAALATKYRFEQVAGSND 441 >2NNH-A nrPDB Length = 476 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 76/499 (15%), Positives = 164/499 (32%), Gaps = 53/499 (10%) Query: 19 LSRRRTRRPGEPPLDLGSIPWLGYALDFG-KDAASFLTRMKEKHGDIFTILVGGRYVTVL 77 ++++ + + PP +P +G L KD T + +G +FT+ G + V Sbjct: 1 MAKKTSSKGKLPP-GPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVF 59 Query: 78 LDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALT 137 + + + + + + + K + +L + Sbjct: 60 HGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMG 119 Query: 138 EAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDR 197 + + E L A + + R Sbjct: 120 KRSIEDRVQEEAHCLVEELR--KTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFL 177 Query: 198 VHSADVFHTFRQLD--RL-----LPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRA 250 FR L+ + P L +K +R + + +A Sbjct: 178 TLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSY--IREKVKEHQA 235 Query: 251 -----HRSKWLESYLLHLEEMGVSE--EMQARALVLQLW----ATQGNMGPAAFWLLLFL 299 + +++ +L+ +E+ ++ E LV + A + LL L Sbjct: 236 SLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLL 295 Query: 300 LKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLT--AAPFI 357 LK+PE A V+ E++ ++ + P Q + P D+V+ E R + + Sbjct: 296 LKHPEVTAKVQEEIDHVIGRHRSPCMQDRS-------HMPYTDAVVHEIQRYSDLVPTGV 348 Query: 358 TREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEK 417 V D R + + +G ++ S D + + +P +F FL+ +G+ K Sbjct: 349 PHAVTTDTKF-----RNYLIPKGTTIMAL-LTSVLHDDKEFPNPNIFDPGHFLDKNGNFK 402 Query: 418 KDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFD 477 K +Y MP+ AG C G A + F+ +L + +L+ ++ ++ + Sbjct: 403 KS---------DYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVD---DLKNLN 450 Query: 478 LSRYGFGL--MQPEHDVPV 494 + G+ + P + + Sbjct: 451 TTAVTKGIVSLPPSYQICF 469 >4R20-A nrPDB Length = 486 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 63/286 (22%), Positives = 109/286 (38%), Gaps = 31/286 (10%) Query: 213 LLPKLARGSLSVGDKDHMC-SVKSRL--WKLLSPARLARRAHRSKWLESYLLHLEEMGVS 269 + P L + C S++ +L KLL + L++ L+ + Sbjct: 209 IFPWLRIFPNKDLKRLKECVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALLIGQQRGSGG 268 Query: 270 EEMQARALVLQLWA-----TQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPV 324 + VL A W + FLL +P+ V+ EL+ + P Sbjct: 269 ADDITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPC 328 Query: 325 SQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLL 384 P+LD+VL E +R+ I ++ +AM ++ +G R+L Sbjct: 329 LSDR-------PHLPLLDAVLCEVMRIRPVSPI---LIPHVAMQDTSLGGHSVPKGTRVL 378 Query: 385 LFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGR 444 + + DP+ + PE F RFL P G +K ++ +P+GAG C+G Sbjct: 379 VN-MWAIHHDPKHWDQPEQFNPERFLEPSGKKK---------TQSSFLPFGAGPRVCVGE 428 Query: 445 SYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEH 490 S A + FV L ++ +P+ R+G ++QPE Sbjct: 429 SLARIELFLFVSRPLQRFSFS-CPSEASLPDLQ-GRFGV-VLQPER 471 >2HI4-A nrPDB Length = 495 Score = 198 bits (504), Expect = 4e-51, Method: Composition-based stats. Identities = 84/486 (17%), Positives = 155/486 (31%), Gaps = 56/486 (11%) Query: 16 LLLLSRRRTRRPG---EPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGR 72 + +L R R P PP G P LG+ L GK+ L+RM +++GD+ I +G Sbjct: 1 MAVLKGLRPRVPKGLKSPPEPWGW-PLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGST 59 Query: 73 YVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE-----KARMKLT 127 V VL + + L + S + + Sbjct: 60 PVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNA 119 Query: 128 LL--------HRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLT 179 L E + L+ E +G + + Sbjct: 120 LNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAM 179 Query: 180 LYGIEALPRTHESQAQDR-------VHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCS 232 +G + E + + S+ F + R LP A ++ + Sbjct: 180 CFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLW- 238 Query: 233 VKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSE------EMQARALVLQLW-ATQ 285 L K + + + + L + G + + LV ++ A Sbjct: 239 ---FLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGF 295 Query: 286 GNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVL 345 + A W L++L+ PE ++ EL++++ + +P P L++ + Sbjct: 296 DTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDR-------PQLPYLEAFI 348 Query: 346 SESLRLTA--APFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEV 403 E+ R ++ I D + F + + + DPE++ DP Sbjct: 349 LETFRHSSFLPFTIPHSTTRDTTL-----NGFYIPK-KCCVFVNQWQVNHDPELWEDPSE 402 Query: 404 FKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLD 463 F+ RFL DG+ K L M +G G C+G A I F+ ++L L+ Sbjct: 403 FRPERFLTADGT------AINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 456 Query: 464 LELINA 469 + Sbjct: 457 FSVPPG 462 >4R1Z-A nrPDB Length = 439 Score = 197 bits (501), Expect = 7e-51, Method: Composition-based stats. Identities = 82/454 (18%), Positives = 155/454 (34%), Gaps = 63/454 (13%) Query: 60 KHGDIFTILVGGRYVTV-LLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPS 118 K G IF R VT LL D + + FH + +F S S Sbjct: 21 KKGKIFAGR--PRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGEG----SVS 74 Query: 119 DEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYL 178 EK ++ RE ++ E + + ++ + + + + + Y Sbjct: 75 IEK------IICREASSMCEVLTESQNSAVD------LGPELTRAVTNVVCALCFNSSY- 121 Query: 179 TLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLW 238 + ES Q D +D + P L D + S Sbjct: 122 -----KRGDAEFESMLQYSQGIVDTVAKDSLVD-IFPWLQI--FPNKDLTILRQCISIRD 173 Query: 239 KLLSPARLARR-----AHRSKWLESYLLHLEEMGVS---------EEMQARALVLQLW-A 283 KLL + + L++ L + E V ++ A Sbjct: 174 KLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFGA 233 Query: 284 TQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDS 343 W + +L+ NP+ ++ EL+S + + P + P L++ Sbjct: 234 GVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDR-------GNLPYLEA 286 Query: 344 VLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEV 403 + E LR+ + ++ +A+ + E+ +++G R+++ S D + + +PE+ Sbjct: 287 TIREVLRIRPVSPL---LIPHVALQDSSVGEYTVQKGTRVVIN-LWSLHHDKKEWKNPEL 342 Query: 404 FKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLD 463 F RFLN +G +P+GAG CLG + A + F+ +L Sbjct: 343 FDPGRFLNEEGD-------GLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFT 395 Query: 464 LELINADVEIPEFDLSRYGFGLMQPEHDVPVRYR 497 LE+ +P+ ++G L + V + R Sbjct: 396 LEMPTGQ-PLPDLQ-GKFGVVLQPKKFKVVAKVR 427 >5YLW-A nrPDB Length = 495 Score = 194 bits (492), Expect = 9e-50, Method: Composition-based stats. Identities = 86/516 (16%), Positives = 181/516 (35%), Gaps = 59/516 (11%) Query: 9 LLAALLLL--LLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFT 66 LLAAL + + RR PP P +G L G + ++ +++G + + Sbjct: 6 LLAALFFIAATITFLSFRRRRNLPP-GPFPYPIVGNMLQLGANPHQVFAKLSKRYGPLMS 64 Query: 67 ILVGGRYVTVLLDP-------HSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSD 119 I +G Y ++ P H + V HA + F + Sbjct: 65 IHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDKISMGFLPVASEWRDM- 123 Query: 120 EKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLT 179 + K + + ++ + LL + + + + ++ L T Sbjct: 124 -RKICKEQMFSNQSMEASQGLRRQKLQQLLDHVQKCSDSGRAVDIREAAFITTLNLMSAT 182 Query: 180 LYGIEALPRTHESQAQDRV------------HSADVFHTFRQLDRLLPKLARGSLSVGDK 227 L+ +A ++ + + + AD F R D +G D Sbjct: 183 LFSSQATEFDSKATMEFKEIIEGVATIVGVPNFADYFPILRPFD------PQGVKRRAD- 235 Query: 228 DHMCSVKSRLWKLLSPARLARRAHR-----SKWLESY--LLHLEEMGVSEEMQARALVLQ 280 + +++ L+ ++RA+ +LE ++ E + ++ Sbjct: 236 VFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQANEFKLKTHHFTHLMLDL 295 Query: 281 LWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPV 340 + W + L+ NP+ +A ++ EL+S+ + + + + P Sbjct: 296 FVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKI-------VDESAMPKLPY 348 Query: 341 LDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTD 400 L +V+ E +R+ + ++ A + + + +G ++L+ + RDP I+TD Sbjct: 349 LQAVIKEVMRIHPPGPL---LLPRKAESDQEVNGYLIPKGTQILIN-AYAIGRDPSIWTD 404 Query: 401 PEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLV 460 PE F RFL+ K DF L +P+G+G C G A + ++ Sbjct: 405 PETFDPERFLD----NKIDFKGQDYEL----LPFGSGRRVCPGMPLATRILHMATATLVH 456 Query: 461 HLDLELINADVEIPEFDLSRYGFGL--MQPEHDVPV 494 + D +L + + +G + P +P+ Sbjct: 457 NFDWKLEDDSTAAADHAGELFGVAVRRAVPLRIIPI 492 >2VE3-A nrPDB Length = 444 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 88/451 (19%), Positives = 146/451 (32%), Gaps = 52/451 (11%) Query: 30 PPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWE 89 PP D G PWLG L+F D F + +++ G IF + G+ V + + + + Sbjct: 14 PPGDFGL-PWLGETLNFLNDG-DFGKKRQQQFGPIFKTRLFGKNVIFISGALANRFLFTK 71 Query: 90 PRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLL 149 + L RI + E R + +L++ + + Sbjct: 72 EQETFQAT---WPLSTRILLGPNALATQMGEIHRSRRKILYQAFL---PRTLDSYLPKMD 125 Query: 150 GDATEAGSGWHEMGL---LDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHT 206 G W + G + +F Sbjct: 126 GIVQGYLEQWGKANEVIWYPQLRRMTFDVAATLFMGEKVSQN------------PQLFPW 173 Query: 207 FRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARR---AHRSKWLESYLLHL 263 F + L L L ++ L L AR+ L L Sbjct: 174 FETYIQGLFSLPIP-LPNTLFGKSQRARALLLAELEKIIKARQQQPPSEEDALGILLAAR 232 Query: 264 EE--MGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAE 321 ++ +S ++L L+A + A L L ++ + VR E Sbjct: 233 DDNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQ-------- 284 Query: 322 QPVSQTTTLPQKVLDSTPVLDSVLSESLRL-TAAPFITREVVVDLAMPMADGREFNLRRG 380 + + L + L P LD VL E LRL RE++ D + F+ +G Sbjct: 285 NKLQLSQELTAETLKKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQF-----QGFHFPKG 339 Query: 381 DRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNH 440 L+ + DP++Y DPE F RF PDGS + ++P+G G Sbjct: 340 -WLVSYQISQTHADPDLYPDPEKFDPERF-TPDGSATHN-------PPFAHVPFGGGLRE 390 Query: 441 CLGRSYAVNSIKQFVFLVLVHLDLELINADV 471 CLG+ +A +K F ++ D L+ Sbjct: 391 CLGKEFARLEMKLFATRLIQQFDWTLLPGQN 421 >4KPA-A nrPDB Length = 494 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 86/460 (18%), Positives = 148/460 (32%), Gaps = 42/460 (9%) Query: 49 DAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIF 108 L ++ ++ G+IF GR VT L + +R D + R F Sbjct: 48 KPVQALMKIADELGEIFKFEAPGR-VTRYLSSQRLIKEACD-ESRFDKNLSQALKFVRDF 105 Query: 109 DVQLPHYSPSDEKARMKLT------LLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEM 162 S + EK K + ++ AM ++ L+ + + Sbjct: 106 AGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYH-AMMVDIAVQLVQKWERLNADE-HI 163 Query: 163 GLLDFSYSFLLRAGYLTLYG-IEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGS 221 + + L L + + + +L R P Sbjct: 164 EVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYD 223 Query: 222 LSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLE---EMGVSEEMQARALV 278 + V + L + R A L L + + +E ++ Sbjct: 224 ENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQII 283 Query: 279 LQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDST 338 L A + L FL+KNP L E +L K + Sbjct: 284 TFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVP--------SYKQVKQL 335 Query: 339 PVLDSVLSESLRL-TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEI 397 + VL+E+LRL AP + D + G E+ L +GD L++ RD I Sbjct: 336 KYVGMVLNEALRLWPTAPAFSLYAKEDTVL----GGEYPLEKGDELMVL-IPQLHRDKTI 390 Query: 398 YTDP-EVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVF 456 + D E F+ RF NP + P+G G C+G+ +A++ + Sbjct: 391 WGDDVEEFRPERFENPSAIPQH-----------AFKPFGNGQRACIGQQFALHEATLVLG 439 Query: 457 LVLVHLDLE-LINADVEIPE-FDLSRYGFGLMQPEHDVPV 494 ++L H D E N +++I E L GF + +P+ Sbjct: 440 MMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL 479 >3K9V-A nrPDB Length = 482 Score = 184 bits (467), Expect = 7e-47, Method: Composition-based stats. Identities = 99/512 (19%), Positives = 177/512 (34%), Gaps = 73/512 (14%) Query: 18 LLSRRRTRRPGEPPLDLGSIPWLGYALDFG-----KDAASFLTRMKEKHGDIFTILVGGR 72 L++ TR + P P LG L+ K L +K+G IF + +G Sbjct: 14 LMTDGETRNVTDLPGPTNW-PLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSF 72 Query: 73 YVTVLLDPHSYDAVVWEPRTRL------------DFHAYAIFLMERIFDVQLPHYSPSDE 120 L P +A+ D A LM E Sbjct: 73 DSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMI----------LEGQE 122 Query: 121 KARMKLTLLHRELQALTEAMYTNLHAVLLGDATE-AGSGWHEMGLLDFSYSFL----LRA 175 R++ + ++ + +L D E E G + YS L + Sbjct: 123 WQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFES 182 Query: 176 GYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLL--PKLARGSLSVGDKDHMCSV 233 L LY E++ + + +++ P L+ Sbjct: 183 ICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLA 242 Query: 234 KSRLWKLLSPARLARRAHRS-----KWLESYLLHLEEMGVSEEMQARALVLQLWATQGNM 288 ++K + P R S +L ++ ++ +E+ A LQL A Sbjct: 243 WDTIFKSVKPCIDNRLQRYSQQPGADFLCD--IYQQDHLSKKELYAAVTELQLAAV-ETT 299 Query: 289 GPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSES 348 + W+L L +NP+A + E++S+L + P ++ L + P L + L ES Sbjct: 300 ANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED-------LRNMPYLKACLKES 352 Query: 349 LRLTA-APFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYN 407 +RLT PF TR + + E+ L +G L L + + + D F+ Sbjct: 353 MRLTPSVPFTTRTLDKPTVL-----GEYALPKGTVLTLNTQV-LGSSEDNFEDSHKFRPE 406 Query: 408 RFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELI 467 R+L K+ K ++P+G G C+GR A ++ + L + +++ Sbjct: 407 RWLQ----------KEKKINPFAHLPFGIGKRMCIGRRLA--ELQLHLALCWIIQKYDIV 454 Query: 468 NADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 499 D E E G++ P ++P+ +R R Sbjct: 455 ATDNEPVEM----LHLGILVPSRELPIAFRPR 482 >6C94-A nrPDB Length = 497 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 72/447 (16%), Positives = 144/447 (32%), Gaps = 44/447 (9%) Query: 70 GGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSP--SDEKARMKLT 127 G+++ L A R F ++ I L P + + Sbjct: 63 VGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGKGLLVLDGPKWFQHRKLLTPG 122 Query: 128 LLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALP 187 + L+ A++ + ++L + + L +G Sbjct: 123 FHYDVLKPYV-AIFADSTRIMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSG 181 Query: 188 RTHES------QAQDRVHSADVFHTFRQLDRLLPKL-ARGSLSVGDKDHMCS-----VKS 235 H ++ + +F+ + + L G + ++ Sbjct: 182 LNHRDSSYYVAVSELTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACRAAHDHTDRVIRQ 241 Query: 236 RLWKLLSPARLARRAHRS--KWLESYLLHLEEMG--VSEEMQARALVLQLWATQGNMGPA 291 R L + +R +L+ L E G +S+ + ++ Sbjct: 242 RKAALQDEKEREKIQNRRHLDFLDILLDVRGESGVQLSDTDLRAEVDTFMFEGHDTTTSG 301 Query: 292 AFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL 351 W L + PE R E+ IL Q Q L L + E RL Sbjct: 302 ISWFLYCMALYPEHQQRCREEVREILGD--QDSFQWEDLA-----KMTYLTMCMKECFRL 354 Query: 352 -TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFL 410 P + R++ ++ DGR L G + + R+ +++ DPEVF RF Sbjct: 355 YPPVPQVYRQLSKPVSF--VDGRS--LPAGSLI-SLHIYALHRNSDVWPDPEVFDPLRF- 408 Query: 411 NPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDL--ELIN 468 +P+ S + Y +P+ AG +C+G+ +A+N +K L L+ + + + Sbjct: 409 SPENSSGRHPY--------AFIPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSVDPLR 460 Query: 469 ADVEIPEFDLSRYGFGLMQPEHDVPVR 495 +++P+ L R G+ + + Sbjct: 461 LPIKLPQLVL-RSKNGIHLYLKPLGPK 486 >3TBG-A nrPDB Length = 479 Score = 179 bits (453), Expect = 3e-45, Method: Composition-based stats. Identities = 82/471 (17%), Positives = 159/471 (33%), Gaps = 47/471 (9%) Query: 44 LDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLD-PHSYDAVVWEPRTRLDFHAYAIF 102 +DF F +++ + GD+F++ + V VL +A+V D I Sbjct: 27 VDFQNTPYCF-DQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPIT 85 Query: 103 ----LMERIFDVQLPHYSPS--DEKARMKLTL--LHRELQALTEAMYTNLHAVLLGDATE 154 R V L Y P+ +++ TL L ++L + + + A Sbjct: 86 QILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANH 145 Query: 155 AGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQ--LDR 212 +G + GLLD + S ++ A E F + L+ Sbjct: 146 SGRPFRPNGLLDKAVSNVI-ASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNA 204 Query: 213 LLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAH--RSKWLESYLLHLEE----- 265 + L +L+ + ++L +LL+ R+ E++L +E+ Sbjct: 205 VPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNP 264 Query: 266 MGVSEEMQARALVLQLW-ATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPV 324 + R +V L+ A W LL ++ +P+ V+ E++ ++ Q +P Sbjct: 265 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPE 324 Query: 325 SQTTTLPQKVLDSTPVLDSVLSESLRL--TAAPFITREVVVDLAMPMADGREFNLRRGDR 382 P +V+ E R +T D+ + + F + +G Sbjct: 325 MGDQA-------HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDI-----EVQGFRIPKGTT 372 Query: 383 LLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCL 442 L + S +D ++ P F FL+ G K +P+ AG CL Sbjct: 373 L-ITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVK---------PEAFLPFSAGRRACL 422 Query: 443 GRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVP 493 G A + F +L H + + + F + +++ Sbjct: 423 GEPLARMELFLFFTSLLQHFSFSV--PTGQPRPSHHGVFAFLVSPSPYELC 471 >5UYS-A nrPDB Length = 494 Score = 178 bits (452), Expect = 4e-45, Method: Composition-based stats. Identities = 78/498 (15%), Positives = 162/498 (32%), Gaps = 61/498 (12%) Query: 31 PLDLGSIPWL---GYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVV 87 PL GS+P+L G+ + ++++K+G I+++ +G + ++ V+ Sbjct: 17 PLV-GSLPFLPRHGHM-------HNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVL 68 Query: 88 WEPRTRLDFHAYAIFLMERI-------FDVQLPHYSPSDEKARMKLTLLHRELQALTEAM 140 + L F H+ A L Q L + + Sbjct: 69 IKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKII 128 Query: 141 YTNLHAVLLGDATEAGSGWHE-----MGLLDFSYSFLLRAGYLTLYGI-EALPRTHESQA 194 + + AT G + + + Y G E + ++ Sbjct: 129 CQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKN--GDPELNVIQNYNEG 186 Query: 195 QDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLA-RRAHRS 253 S D ++ P L K H+ L K+L + R + Sbjct: 187 IIDNLSKDSLVDLVPWLKIFPNKTLEKL----KSHVKIRNDLLNKILENYKEKFRSDSIT 242 Query: 254 KWLESYLLHL-----------EEMGVSEEMQARALVLQLW-ATQGNMGPAAFWLLLFLLK 301 L++ + ++ + + + ++ A W L FLL Sbjct: 243 NMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLH 302 Query: 302 NPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREV 361 NP+ + E++ + + P + +L++ + E LRL + + Sbjct: 303 NPQVKKKLYEEIDQNVGFSRTPTISDR-------NRLLLLEATIREVLRLRPVAPM---L 352 Query: 362 VVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFY 421 + A + EF + +G +++ + + + + P+ F RFLNP G+ Sbjct: 353 IPHKANVDSSIGEFAVDKGTEVIIN-LWALHHNEKEWHQPDQFMPERFLNPAGT------ 405 Query: 422 KDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRY 481 +P+GAG C+G A + + +L DLE+ + + + Sbjct: 406 -QLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKV 464 Query: 482 GFGLMQPEHDVPVRYRIR 499 F + + + VR R Sbjct: 465 VFLIDSFKVKIKVRQAWR 482 >3DL9-A nrPDB Length = 479 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 82/478 (17%), Positives = 149/478 (31%), Gaps = 83/478 (17%) Query: 50 AASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFD 109 ++ + + +G+IF++ +GG VL ++ H IF Sbjct: 36 PHVYMRKQSQVYGEIFSLDLGGISTVVLNG--------YDVVKECLVHQSEIFADRPCLP 87 Query: 110 VQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWH--EMGLLD- 166 MK+T + L + + + + + G G E +L+ Sbjct: 88 ------------LFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEE 135 Query: 167 ----------------FSYSFLLRAGY----LTLYGIEALPRTHESQAQDRVHSADVFHT 206 + A L ++G + Q + S +V Sbjct: 136 TKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELA 195 Query: 207 FRQLDRL---LPKLARGSLSVGDKDHMCSV--KSRLWKLLSPARLARRAH-RSKWLESYL 260 L P + + + L +L+ A + R+ ++++YL Sbjct: 196 ASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYL 255 Query: 261 LHLE--EMGVSEEMQARALVL----QLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELE 314 ++ + S L+ + A W +LF+ P V+ E++ Sbjct: 256 DEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEID 315 Query: 315 SILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL--TAAPFITREVVVDLAMPMADG 372 I+ +P P ++VL E LR I D A Sbjct: 316 LIMGPNGKPSWDDKC-------KMPYTEAVLHEVLRFCNIVPLGIFHATSED-----AVV 363 Query: 373 REFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNM 432 R +++ +G + + S D + + DPEVF RFL+ G K K + Sbjct: 364 RGYSIPKGTTV-ITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAK---------KEALV 413 Query: 433 PWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEH 490 P+ G HCLG A + F +L L + V DL +QP+ Sbjct: 414 PFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVP----DLKPRLGMTLQPQP 467 >6IQ5-A nrPDB Length = 463 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 81/474 (17%), Positives = 154/474 (32%), Gaps = 54/474 (11%) Query: 54 LTRMKEKHGDIFTILVGGRYVTVLLDPHS-YDAVVWEPRTRLDFHAYAIFLMERIFDVQ- 111 R+ ++GD+F I +G + VL + + A+V + D ++A F R+ Sbjct: 7 FARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASF---RVVSGGR 63 Query: 112 ---LPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGS---GWHEMGLL 165 HYS + R + R L +L +A E + G Sbjct: 64 SMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAF 123 Query: 166 DFSYSFLL----RAGYLTLYG-------IEALPRTHESQAQDRVHSADVFHTFRQLDRLL 214 + +G E ++ R A + Sbjct: 124 LDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYF 183 Query: 215 PKLARGSLSVGDKDHMCSVKSRLWKLLSP-ARLARRAHRSKWLESYLLHLEEMGVSEE-- 271 P R ++ + L K L L A +++++L E+ + Sbjct: 184 PNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHG 243 Query: 272 -------MQARALVLQLW-ATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQP 323 A + ++ A+Q + A WLLL + P+ V+ EL+ ++ + P Sbjct: 244 GGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLP 303 Query: 324 VSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRL 383 + P + + L E++R ++ + +++ + + Sbjct: 304 CMGDQ-------PNLPYVLAFLYEAMRFSS---FVPVTIPHATTANTSVLGYHIPKDTVV 353 Query: 384 LLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLG 443 + S DP + +PE F RFL+ DG KD L + M + G C+G Sbjct: 354 FVNQ-WSVNHDPVKWPNPENFDPARFLDKDGLINKD-------LTSRVMIFSVGKRRCIG 405 Query: 444 RSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYR 497 + + F+ ++ D E + + S YG + V V R Sbjct: 406 EELSKMQLFLFISILAHQCDFR--ANPNEPAKMNFS-YGLTIKPKSFKVNVTLR 456 >3MDV-A nrPDB Length = 456 Score = 160 bits (404), Expect = 2e-39, Method: Composition-based stats. Identities = 75/459 (16%), Positives = 144/459 (31%), Gaps = 46/459 (10%) Query: 54 LTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLD---FHAYAIFLMERIFDV 110 +K+G + + V + ++ P S + + D + A ER+F Sbjct: 16 FLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ 75 Query: 111 QLPHYSPSD----EKARMKLTLLHRELQALTE---AMYTNLHAVLLGDATEAGSGWHEMG 163 L + ++ + L L +L E L +L A + Sbjct: 76 GLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDM 135 Query: 164 LLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFH---TFRQLDRLLPKLARG 220 L + L +A +G+E + + + + L + LP + Sbjct: 136 LTYTAMDILAKAA----FGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQ 191 Query: 221 SLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQ 280 V + R W L R + + +L EE +E V Sbjct: 192 LREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTF 251 Query: 281 LWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPV 340 A + ++ L + PE +A ++ E++ ++ L + L Sbjct: 252 FIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY-------LDFEDLGRLQY 304 Query: 341 LDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTD 400 L VL ESLRL + T ++ + + + LL ++ + D + D Sbjct: 305 LSQVLKESLRLYPPAWGTFRLLEEETLID----GVRVPGNTPLLFSTYVMGRMD-TYFED 359 Query: 401 PEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLV 460 P F +RF + + P+ GH C+G+ +A +K + +L Sbjct: 360 PLTFNPDRF-----------GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQ 408 Query: 461 HLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 499 L+ L+ ++P V R R Sbjct: 409 RLEFRLVPGQ------RFGLQEQATLKPLDPVLCTLRPR 441 >3QZ1-A nrPDB Length = 496 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 94/510 (18%), Positives = 168/510 (32%), Gaps = 83/510 (16%) Query: 23 RTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHS 82 + R PPL G + L L L+ + +K G ++ + +G + V VL + Sbjct: 24 KLRNLHLPPLVPGFLHLLQPNL-----PIHLLS-LTQKLGPVYRLRLGLQEVVVLNSKRT 77 Query: 83 YDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYT 142 + + F Q+P Y ++ + + + L +A Sbjct: 78 IE--------EAMIRKWVDFAGRP----QIPSYKLVSQRCQ---DISLGDYSLLWKAHKK 122 Query: 143 NLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAG-------YLTLYGIEALPRTHESQAQ 195 + LL + W + +F ++AG +L + + Sbjct: 123 LTRSALLLGTRSSMEPWVDQLTQEFCERMRVQAGAPVTIQKEFSLLTCSIICYLTFGNKE 182 Query: 196 DRVHSA------DVFHTFR----------QLDRLLPK--LARGSLSVGDKDHMCSVKSRL 237 D + A D+ T+ R P L R ++ ++DHM + R Sbjct: 183 DTLVHAFHDCVQDLMKTWDHWSIQILDMVPFLRFFPNPGLWRLKQAIENRDHMVEKQLRR 242 Query: 238 WKLLSPARLARRAHRSKWLESYLLHLEEMGVSE--EMQARALVLQLW-ATQGNMGPAAFW 294 K A R L+ E G + E V+ L+ W Sbjct: 243 HKESMVAGQWR-DMTDYMLQGVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSW 301 Query: 295 LLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAA 354 + FLL +PE ++ EL+ L P + + + K P+L++ ++E LRL Sbjct: 302 AVAFLLHHPEIQRRLQEELDRELG----PGASCSRVTYKDRARLPLLNATIAEVLRLRPV 357 Query: 355 PFITREVVVDLAMPMADGR-----EFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRF 409 V LA+P R +++ G +++ D ++ P F+ +RF Sbjct: 358 --------VPLALPHRTTRPSSIFGYDIPEG-MVVIPNLQGAHLDETVWEQPHEFRPDRF 408 Query: 410 LNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINA 469 L P + + +G G CLG S A + + +L L L Sbjct: 409 LEPGANP-------------SALAFGCGARVCLGESLARLELFVVLARLLQAFTL-LPPP 454 Query: 470 DVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 499 +P Y G+ VR + R Sbjct: 455 VGALPSLQPDPY-CGVNLKVQPFQVRLQPR 483 >5VBU-A nrPDB Length = 476 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 83/504 (16%), Positives = 170/504 (33%), Gaps = 62/504 (12%) Query: 19 LSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLL 78 ++++ + + PPL G + + L D +L + +K G I+ + +G + V VL Sbjct: 1 MAKKTSSKGKLPPLAPGFL----HLLQ--PDLPIYLLGLTQKFGPIYRLHLGLQDVVVLN 54 Query: 79 DPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSD-------EKARMKLTLL-- 129 + + + + DF L ++ P S D K + LL Sbjct: 55 SKRTIEEAM--VKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLG 112 Query: 130 -HRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALP- 187 ++ + E + + + E LL + +P Sbjct: 113 IRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLT-CSIICYLTFGDKIKDDNLMPA 171 Query: 188 --RTHESQAQDRVHSADVFHTFRQLDRLLPK--LARGSLSVGDKDHMCSVKSRLWKLLSP 243 + + + H + R P L R ++ +DH+ L Sbjct: 172 YYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVE------MQLRQ 225 Query: 244 ARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVL--------QLWATQGNMGPAAFWL 295 + + A + + + Y+L EE + L L W Sbjct: 226 HKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWA 285 Query: 296 LLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAP 355 ++FLL +PE ++ EL+ L P + ++ +P K P+L++ ++E LRL P Sbjct: 286 VVFLLHHPEIQQRLQEELDHELG----PGASSSRVPYKDRARLPLLNATIAEVLRLR--P 339 Query: 356 FITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGS 415 + + P + +++ G +++ D ++ P F +RFL P + Sbjct: 340 VVPLALPHRTTRP-SSISGYDIPEGT-VIIPNLQGAHLDETVWERPHEFWPDRFLEPGKN 397 Query: 416 EKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPE 475 + + +G G CLG A + + +L L+ + +P Sbjct: 398 SR-------------ALAFGCGARVCLGEPLARLELFVVLTRLLQ--AFTLLPSGDALPS 442 Query: 476 FDLSRYGFGLMQPEHDVPVRYRIR 499 + +++ VR + R Sbjct: 443 LQPLPHCSVILK-MQPFQVRLQPR 465 >3N9Z-A nrPDB Length = 487 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 82/461 (17%), Positives = 159/461 (34%), Gaps = 49/461 (10%) Query: 56 RMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVW----EPRTRLDFH--AYAIFLMERIFD 109 + +K+G I+ +G ++DP + P L AY + I Sbjct: 40 QNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGV 99 Query: 110 VQLPHYSPSDEKARMKLTLLHRELQA----LTEAMYTNLHAVLLGDATEAGSGWHEMGLL 165 + + ++ + ++ E L +A+ + +VL +AGSG + + Sbjct: 100 LLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDIS 159 Query: 166 DFSYSFLLRAGYLTLYGIE---ALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSL 222 D + F + ++G + + +FHT + L P L R Sbjct: 160 DDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFR 219 Query: 223 SVGDKDHMCSVKSRLWKLLSP------ARLARRAHRSKWLESYLLHLEEMGVSEEMQARA 276 + KDH+ + K + + + L + +S E Sbjct: 220 TKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKAN 279 Query: 277 LVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLD 336 + L W L + +N + +R E +L Q T+ L Sbjct: 280 VTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAE---VLAARHQAQGDMATM----LQ 332 Query: 337 STPVLDSVLSESLRLTAAPF-ITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDP 395 P+L + + E+LRL + R +V DL + R++ + + + + R+P Sbjct: 333 LVPLLKASIKETLRLHPISVTLQRYLVNDLVL-----RDYMIPAKTLVQVA-IYALGREP 386 Query: 396 EIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFV 455 + DPE F R+L+ KD N+ +G G CLGR A + F+ Sbjct: 387 TFFFDPENFDPTRWLS----------KDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFL 436 Query: 456 FLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRY 496 +L + +E+ + D+ ++ PE + + Sbjct: 437 INMLENFRVEIQHLS------DVGTTFNLILMPEKPISFTF 471 >3MZS-A nrPDB Length = 486 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 77/503 (15%), Positives = 163/503 (32%), Gaps = 52/503 (10%) Query: 19 LSRRRTRRPGE---PPLDLGSIPWLGYALDFGKDAASF-LTRMKEKHGDIFTILVGGRYV 74 ++ +T RP P D G + + + G F +K+G I+ +G Sbjct: 1 MASTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLES 60 Query: 75 TVLLDPH--SYDAVVWEPRTR-------LDFHAYAIFLMERIFDVQLPHYSPSD--EKAR 123 ++ P ++ L +H Y + +F Sbjct: 61 VYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEV 120 Query: 124 MKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGI 183 M + + L + + ++L + GSG + + + F + ++G Sbjct: 121 MAPEAIKNFIPLLNP-VSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGE 179 Query: 184 EALPRTHESQ---AQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKL 240 + +FHT L + P+L R + +DH+ + + K Sbjct: 180 RLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKA 239 Query: 241 -----LSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWL 295 + L R+ + L+ + E + L W Sbjct: 240 EKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWH 299 Query: 296 LLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAP 355 L + ++ +R E +L Q + + Q V P+L + + E+LRL Sbjct: 300 LYEMARSLNVQEMLREE---VLNARRQAEGDISKMLQMV----PLLKASIKETLRLHPIS 352 Query: 356 FITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGS 415 + +++ + + + + RDP ++ P+ F R+L+ Sbjct: 353 V----TLQRYPESDLVLQDYLIPAKTLVQVA-IYAMGRDPAFFSSPDKFDPTRWLS---- 403 Query: 416 EKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPE 475 KD + N+ +G G C+GR A + F+ +L + +E+ I + Sbjct: 404 ------KDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEM----QHIGD 453 Query: 476 FDLSRYGFGLMQPEHDVPVRYRI 498 D ++ P+ + + +R Sbjct: 454 VDT--IFNLILTPDKPIFLVFRP 474 >6M7X-A nrPDB Length = 484 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 75/411 (18%), Positives = 147/411 (35%), Gaps = 53/411 (12%) Query: 59 EKHGDIFTILVGGRYVTVLLDPHSYDAV----VWEPRTRLDFHAYAIFLMERIFDVQLPH 114 ++ G IF +GG + ++ P + + P R+ + + R + Sbjct: 50 QELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHP-HRMSLEPWVAYRQHRGHKCGVFL 108 Query: 115 YS-PSDEKARMKLT---LLHRELQALTE---AMYTNLHAVLLGDATEAGSGWHEMGLLDF 167 + P R++L L +Q A+ + L + G + + Sbjct: 109 LNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPS 168 Query: 168 SYSFLLRAGYLTLYGIEALPRTHE---SQAQDRVHSADVFHTFRQLDRLLPKLARGSLSV 224 + + + A L L+G H + +F + QL + L+R + Sbjct: 169 IFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPK 228 Query: 225 GDKDHMCS-------VKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARAL 277 K+H + + + K+ +R + + LL + ++A ++ Sbjct: 229 VWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLL--NAELSPDAIKANSM 286 Query: 278 VLQLWATQGNMGPAAFW---LLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKV 334 L T G++ F L L +NP A+R E + + + PQK Sbjct: 287 EL----TAGSVDTTVFPLLMTLFELARNPNVQQALRQE-------SLAAAASISEHPQKA 335 Query: 335 LDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRD 394 P+L + L E+LRL + +A + +++ G + +F S R+ Sbjct: 336 TTELPLLRAALKETLRLYPVGLF----LERVASSDLVLQNYHIPAGTLVRVF-LYSLGRN 390 Query: 395 PEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRS 445 P ++ PE + R+L+ GS + Y++P+G G CLGR Sbjct: 391 PALFPRPERYNPQRWLDIRGSGR----------NFYHVPFGFGMRQCLGRR 431 >4ZGX-A nrPDB Length = 489 Score = 125 bits (314), Expect = 4e-29, Method: Composition-based stats. Identities = 74/414 (17%), Positives = 145/414 (35%), Gaps = 49/414 (11%) Query: 54 LTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAV----VWEPRTRLDFHAYAIFLMERIFD 109 + + ++ G IF +GG + ++ P + + P + + + R Sbjct: 45 MHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEP-WVAYRQHRGHK 103 Query: 110 VQLPHYS-PSDEKARMKLT---LLHRELQALTE---AMYTNLHAVLLGDATEAGSGWHEM 162 + + P R++L L + +Q A+ + L + G + Sbjct: 104 CGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTL 163 Query: 163 GLLDFSYSFLLRAGYLTLYGIEALPRTHE---SQAQDRVHSADVFHTFRQLDRLLPKLAR 219 + + + + A L L+G H + +F + QL + L+R Sbjct: 164 DVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSR 223 Query: 220 GSLSVGDKDHMCS-------VKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEM 272 K+H + + + K+ R H + + LL E +S E Sbjct: 224 WISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAE---LSLEA 280 Query: 273 QARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQ 332 + + L L +NP+ +R E + + + PQ Sbjct: 281 IKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQE-------SLAAAASISEHPQ 333 Query: 333 KVLDSTPVLDSVLSESLRL-TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSP 391 K P+L + L E+LRL F+ R V DL + + +++ G + +F S Sbjct: 334 KATTELPLLRAALKETLRLYPVGLFLERVVSSDLVL-----QNYHIPAGTLVQVF-LYSL 387 Query: 392 QRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRS 445 R+ ++ PE + R+L+ GS + +++P+G G CLGR Sbjct: 388 GRNAALFPRPERYNPQRWLDIRGSGR----------NFHHVPFGFGMRQCLGRR 431 >3S79-A nrPDB Length = 503 Score = 115 bits (288), Expect = 4e-26, Method: Composition-based stats. Identities = 42/323 (13%), Positives = 101/323 (31%), Gaps = 39/323 (12%) Query: 154 EAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVF----HTFRQ 209 E + + +L +L I + Q + F + Sbjct: 177 EVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFK 236 Query: 210 LDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPAR--LARRAHRSKWLESYLLHLEEMG 267 + L K + + D L + + +L + Sbjct: 237 ISWLYKKYEKSVKDLKD------AIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD 290 Query: 268 VSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQT 327 ++ E + ++ L A M + F++L + K+P A+ E+++++ + Sbjct: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE-------- 342 Query: 328 TTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFP 387 + + V+++ + ES+R ++V+ A+ + +++G ++L Sbjct: 343 RDIKIDDIQKLKVMENFIYESMRYQPV----VDLVMRKALEDDVIDGYPVKKGTNIILN- 397 Query: 388 FLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYA 447 + E + P F F Y P+G G C G+ A Sbjct: 398 -IGRMHRLEFFPKPNEFTLENFA-------------KNVPYRYFQPFGFGPRGCAGKYIA 443 Query: 448 VNSIKQFVFLVLVHLDLELINAD 470 + +K + +L ++ + Sbjct: 444 MVMMKAILVTLLRRFHVKTLQGQ 466 >3NC3-A nrPDB Length = 441 Score = 99.2 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 69/422 (16%), Positives = 141/422 (33%), Gaps = 71/422 (16%) Query: 45 DFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPR---TRLDFHAYAI 101 F + ++ ++++E+ + + + H ++ P T+ Sbjct: 50 QFQNNPYAYFSQLREEDPVHYEESI---DSYFISRYHDVRYILQHPDIFTTKSLVERAEP 106 Query: 102 FLMERIFDVQLPHYSPSDEKARMKL-TLLHRELQALTEAMYTNLHAVLLGDATEAGSGWH 160 + + H K R+ + + + L L+ + N +L Sbjct: 107 VMRGPVLAQM--HGKEHSAKRRIVVRSFIGDALDHLSPLIKQNAENLLAP-----YLERG 159 Query: 161 EMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARG 220 + L++ A +T+ + R HE ++ AD + Q Sbjct: 160 KSDLVNDFGKT--FAVCVTMDMLGLDKRDHEKISEWHSGVADFITSISQ----------- 206 Query: 221 SLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGV--SEEMQARALV 278 S + H +L + L P RR + L S L E G+ S++ ++ Sbjct: 207 --SPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMALSDKDILALIL 264 Query: 279 LQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDST 338 L A ++ LL NPE + VL Sbjct: 265 NVLLAATEPADKTLALMIYHLLNNPEQM-------------------------NDVLADR 299 Query: 339 PVLDSVLSESLRL-TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEI 397 ++ ++E+LR I R++ D + +++ + + RDPE Sbjct: 300 SLVPRAIAETLRYKPPVQLIPRQLSQDTVV-----GGMEIKKDTIVFCM-IGAANRDPEA 353 Query: 398 YTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFL 457 + P+VF +R D K F + ++ +G+G ++C+G ++A N I+ + Sbjct: 354 FEQPDVFNIHR---EDLGIKSAFSGAAR-----HLAFGSGIHNCVGTAFAKNEIEIVANI 405 Query: 458 VL 459 VL Sbjct: 406 VL 407 >3EJB-B nrPDB Length = 404 Score = 96.1 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 68/422 (16%), Positives = 131/422 (31%), Gaps = 72/422 (17%) Query: 45 DFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHA-----Y 99 +F K+ SF ++ H I+ + A++ + R ++ Sbjct: 10 EFLKNPYSFYDTLRAVH-PIYKGSFLKYPGWYVTGYEETAAILKDARFKVRTPLPESSTK 68 Query: 100 AIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGW 159 L + L P + R TL T Y + + G Sbjct: 69 YQDLSHVQNQMMLFQNQPDHRRLR---TLASGAFTPRTTESYQPYIIETVHHLLDQVQGK 125 Query: 160 HEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLAR 219 +M ++ L + G+ P Q ++ S F + + L Sbjct: 126 KKMEVISDFAFPLASFVIANIIGV---PEEDREQLKEWAASLIQTIDFTRSRKAL----- 177 Query: 220 GSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVL 279 + +L+ +R + + L E+ ++EE A +L Sbjct: 178 ----TEGNIMAVQAMAYFKELIQKR---KRHPQQDMISMLLKGREKDKLTEEEAASTCIL 230 Query: 280 QLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTP 339 A +L LL++PE L +R + Sbjct: 231 LAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPD------------------------- 265 Query: 340 VLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYT 399 ++ + + E LR + ++ +A D +R+G+++ L + RDP I+T Sbjct: 266 LIGTAVEECLRYESP----TQMTARVASEDIDICGVTIRQGEQVYLLLG-AANRDPSIFT 320 Query: 400 DPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVL 459 +P+VF R N ++ +G GH+ CLG S A + + +L Sbjct: 321 NPDVFDITR------------------SPNPHLSFGHGHHVCLGSSLARLEAQIAINTLL 362 Query: 460 VH 461 Sbjct: 363 QR 364 >1CPT-A nrPDB Length = 428 Score = 92.2 bits (227), Expect = 4e-19, Method: Composition-based stats. Identities = 74/446 (16%), Positives = 136/446 (30%), Gaps = 85/446 (19%) Query: 60 KHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPH--YSP 117 KH D+ I G+ + + + + + M I PH S Sbjct: 56 KHADVMQI---GKQPGLFSNAEG---------SEILYDQNNEAFMRSISG-GCPHVIDSL 102 Query: 118 SDEKARMKLTLLHRELQALTEAMY----TNLHAVLLGDATEAGSGWHEMGLLDFSYSFLL 173 + L A N+ + E + Sbjct: 103 TSMDPPTHTAYRGLTLNWFQPASIRKLEENIRRIAQASVQRLLDFDGECDFMTDCAL--- 159 Query: 174 RAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSV 233 Y L+ + E + F + D R S + Sbjct: 160 ---YYPLHVVMTALGVPEDDEPLMLKLTQDFFGVHEPDEQAVAAPRQSADEAARRF-HET 215 Query: 234 KSRLWKLLSPARLARRAHRSKWLESYLL--HLEEMGVSEEMQARALVLQLWATQGNMGPA 291 + + + + RR+ + S L L+ + ++ V A + Sbjct: 216 IATFYDYFNGFTVDRRSCPKDDVMSLLANSKLDGNYIDDKYINAYYVAIATAGHDTTSSS 275 Query: 292 AFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL 351 + ++ L +NPE LA L + P L + E++R Sbjct: 276 SGGAIIGLSRNPEQLA----------------------LAKSDPALIPRL---VDEAVRW 310 Query: 352 TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLN 411 TA + + A+ + R N++RGDR++L + S RD E++++P+ F RF Sbjct: 311 TAP----VKSFMRTALADTEVRGQNIKRGDRIMLS-YPSANRDEEVFSNPDEFDITRF-- 363 Query: 412 PDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVL-VHLDLELINAD 470 N ++ +G G + CLG+ A +K F +L +EL Sbjct: 364 ----------------PNRHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSG-- 405 Query: 471 VEIPEFDLSRYGFGLMQPEHDVPVRY 496 P + + G +VP+R+ Sbjct: 406 --PPRLVATNFVGG----PKNVPIRF 425 >1WIY-A nrPDB Length = 389 Score = 89.5 bits (220), Expect = 3e-18, Method: Composition-based stats. Identities = 70/375 (18%), Positives = 114/375 (30%), Gaps = 75/375 (20%) Query: 119 DEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYL 178 + + +K L + ++ EAM A E HEM L S L RA Sbjct: 89 EARKALKDPFLPKSVRGYREAMEEEAWAFFGEWRGEERDLDHEM--LALSLRLLGRA--- 143 Query: 179 TLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLW 238 L+G P E H + LDR++ + + Sbjct: 144 -LFGKPLSPSLAE-------------HALKALDRIMAQTRSPLALLDLAAEA-------- 181 Query: 239 KLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLF 298 R + E+ ++H + E V L A + A W L Sbjct: 182 -----RFRKDRGALYREAEALIVHPPLSHLPRERALSEAVTLLVAGHETVASALTWSFLL 236 Query: 299 LLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFIT 358 L P+ V E+ L E+LRL +I Sbjct: 237 LSHRPDWQKRVAESEEAALAA-------------------------FQEALRLYPPAWI- 270 Query: 359 REVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKK 418 + L P+ G + L +G L+L P+++ + + + E F+ RFL G+ Sbjct: 271 --LTRRLERPLLLGED-RLPQGTTLVLSPYVTQRL---YFPEGEAFQPERFLAERGT--- 321 Query: 419 DFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDL 478 P+G G CLGR +A+ + L+ + + + L Sbjct: 322 --------PSGRYFPFGLGQRLCLGRDFALLEGPIVLRAFFRRFRLDPLPFPRVLAQVTL 373 Query: 479 SRYGFGLMQPEHDVP 493 G +P V Sbjct: 374 RPEGGLPARPREGVR 388 >4GGV-A nrPDB Length = 418 Score = 87.2 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 57/385 (14%), Positives = 114/385 (29%), Gaps = 64/385 (16%) Query: 106 RIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLL 165 + + + P + + L+ R A A + + +A G E+ + Sbjct: 89 PLLEGDMSQMDPPRHRKYRQ--LVSRAFTPRLVADMETRVADITRELLDAVDGKPEIEIA 146 Query: 166 DFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVG 225 L L G+ A R + D D+ F L Sbjct: 147 ADLAYPLPVIVIAELLGVPAGDRDLFKKWAD-----DIIEGFSGFSFLD----TSGQGEQ 197 Query: 226 DKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLH--LEEMGVSEEMQARALVLQLWA 283 D L ++ RR + L ++L+ ++ +++ + L Sbjct: 198 DVRDATERLRPLLDYMAGHVTERRRTPREDLLTHLVQAEVDGERLTDNEIVNVANILLVT 257 Query: 284 TQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDS 343 +L L +PE A VR + + Sbjct: 258 GHITTTMTLGNTVLCLDADPEVAAKVRADRSLVPGA------------------------ 293 Query: 344 VLSESLR-LTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPE 402 + E+LR L+ + + R ++ + + + D++++ + RDP +TDPE Sbjct: 294 -IEEALRVLSPSAALARGTSREV-----EVAGTVIPK-DQIVMLWLGAGNRDPRQFTDPE 346 Query: 403 VFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHL 462 V+ R N + +G G + CLG A + + + Sbjct: 347 VYDPTR------------------DPNPHFGFGRGIHFCLGAPLARLEGRVALNALFDRF 388 Query: 463 DLELINADVEIPEFDLSRYGFGLMQ 487 + L + P F + G+ Sbjct: 389 PV-LRTDPAKPPTFFPTPDMIGVNT 412 >2VZM-A nrPDB Length = 436 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 74/491 (15%), Positives = 142/491 (28%), Gaps = 99/491 (20%) Query: 22 RRTRRPG--EPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVG-GRYVTVLL 78 RRT++ PP+ LG DF D R++ + G + G V +++ Sbjct: 22 RRTQQGTTASPPVLDLGA--LGQ--DFAADPYPTYARLRAE-GPAHRVRTPEGNEVWLVV 76 Query: 79 DPHSYDAVVWEPRTRLDFHAYAIFLM-------ERIFDVQLPHYSPSDEKARMKLTLLHR 131 AV+ +PR D+ L + + P ++ + + R Sbjct: 77 GYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHT--RLRKLVAREFTMR 134 Query: 132 ELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHE 191 ++ L + + ++ + L++ L L G+ R Sbjct: 135 RVELLRPRVQEIVDGLVDA---MLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAF 191 Query: 192 SQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAH 251 D + P + + + LS ++R Sbjct: 192 RVWTD--------------AFVFPDDPA---------QAQTAMAEMSGYLSRLIDSKRGQ 228 Query: 252 RSKWLESYLLHL---EEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAA 308 + L S L+ + ++ E + L A + LL +P+ LAA Sbjct: 229 DGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAA 288 Query: 309 VRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMP 368 +R +LD + E LR + Sbjct: 289 LRA-------------------------DMTLLDGAVEEMLRYEGP---VESATYRFPVE 320 Query: 369 MADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLK 428 D + GD +L+ R PE + DP F R Sbjct: 321 PVDLDGTVIPAGDTVLVV-LADAHRTPERFPDPHRFDIRR------------------DT 361 Query: 429 NYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADV-EIPEFDLSRYGFGLMQ 487 ++ +G G + C+G A + V +L ++ +L Y +++ Sbjct: 362 AGHLAFGHGIHFCIGAPLARLEARIAVRALLER-----CPDLALDVSPGELVWYPNPMIR 416 Query: 488 PEHDVPVRYRI 498 +P+R+R Sbjct: 417 GLKALPIRWRR 427 >5L94-A nrPDB Length = 410 Score = 85.7 bits (210), Expect = 4e-17, Method: Composition-based stats. Identities = 46/272 (16%), Positives = 85/272 (31%), Gaps = 57/272 (20%) Query: 227 KDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMG--VSEEMQARALVLQLWAT 284 + L +R + S LL +E G +++E +L L A Sbjct: 184 QQEKMKANDELETYFYRIIEEKRTRPGDDIISVLLQAKEEGKQLTDEEIVGFSILLLIAG 243 Query: 285 QGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSV 344 + L+++ + ++ E + +L Sbjct: 244 NETTTNLISNTIYCLMEDKASFERLKRE-KELLPSG------------------------ 278 Query: 345 LSESLRLT-AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEV 403 + E LR + R V D+ + L+ G+ ++ + S RD E + DPEV Sbjct: 279 IEEVLRYRSPVQALHRIVKEDVTLAGKK-----LKAGEHVVPWMG-SAHRDAEYFEDPEV 332 Query: 404 FKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLD 463 FK +R N +M +G G + CLG A K + ++ Sbjct: 333 FKIDR------------------KPNVHMAFGRGIHFCLGAPLARIEAKIMLAELIDRY- 373 Query: 464 LELINADVEIPEFDLSRYGFGLMQPEHDVPVR 495 P F+L + ++ +R Sbjct: 374 ----PQMDWSPSFELKPIESTFVYGLKELLIR 401 >5VWS-A nrPDB Length = 393 Score = 82.2 bits (201), Expect = 4e-16, Method: Composition-based stats. Identities = 58/345 (16%), Positives = 98/345 (28%), Gaps = 66/345 (19%) Query: 120 EKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLT 179 + R + L+ + + + + G E L++ L Sbjct: 84 PEHRHQRRLITHAFTPQSISAMEPRIRQIADHLLDELPG-PEFDLVEHFAYPLPVIVIAE 142 Query: 180 LYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWK 239 L G+ R DR+ S V + P+LAR + + + + Sbjct: 143 LLGVPPGDRHLFRTWSDRLMSLQVE------NYADPELAR---------TVAAAMTEMND 187 Query: 240 LLSPARLARRAHRSKWLESYLLH--LEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLL 297 L +RR H L + L+ +E + E L L A +L Sbjct: 188 YLREHCRSRRTHPRDDLLTRLVQAEVEGKRLDLEEVVNTASLLLLAGHLTTTVLIGNTML 247 Query: 298 FLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFI 357 L +PEA AVR + I + L ESLRL + Sbjct: 248 CLWDHPEAEKAVRADPSLIP-------------------------AALEESLRLRSPFLQ 282 Query: 358 TREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEK 417 V + ++ + LS D + DPE F +R Sbjct: 283 AGRVTTR----DVTIAGETIPANRFVMAW-ILSANHDDRRFPDPERFDLHR--------- 328 Query: 418 KDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHL 462 ++ +G G + CLG + + +L Sbjct: 329 ---------QTTGHIAFGHGVHFCLGAQLGRLEGRIALERLLGRF 364 >4WPZ-A nrPDB Length = 397 Score = 80.7 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 46/267 (17%), Positives = 86/267 (32%), Gaps = 50/267 (18%) Query: 232 SVKSRLWKLLSPARLARRAHRSKWLESYLLHLEE--MGVSEEMQARALVLQLWATQGNMG 289 + L +R + + L S L+ + + ++E + L A Sbjct: 179 AATVSLVNYFGELIAVKRENPADDLISELIAISDGDSTLTEREIIALSIGILSAGHETTA 238 Query: 290 PAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESL 349 L+ LL NPE L +R E+I + E L Sbjct: 239 NQISMFLVTLLHNPEELDKLRDNREAIP-------------------------KAVDELL 273 Query: 350 RLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRF 409 R + + L G ++L + RDPE++ D E R Sbjct: 274 RFVPLTTTGGIIPRLTTAEVELSGGQVLPAG-AVVLPAVATANRDPEVFEDGERLNVTRE 332 Query: 410 LNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINA 469 NP ++ +GAG +HCLG A +++ + +L + Sbjct: 333 NNP------------------HLAFGAGIHHCLGAQLARIELQEALGAILDR----MPQV 370 Query: 470 DVEIPEFDLSRYGFGLMQPEHDVPVRY 496 + +PE +L +++ +P+ + Sbjct: 371 RLAVPESELRLKSASIIRGLESLPITW 397 >5EX6-C nrPDB Length = 434 Score = 80.7 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 42/244 (17%), Positives = 79/244 (32%), Gaps = 48/244 (19%) Query: 228 DHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGN 287 + + L R L ++ V++E V + A N Sbjct: 217 RRRAAAGEAFSRYLVTMVARERKDPGDGLIGMVVAEHGDTVTDEELRGVCVQMMLAGDDN 276 Query: 288 MGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSE 347 + +L LL+NPE +AA+RG++ P + + E Sbjct: 277 ISGMIGLGVLALLRNPEQIAALRGDV-------------------------PAAERAVDE 311 Query: 348 SLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYN 407 +R P+ A+ + + ++ G+ +L + RDP + D + Sbjct: 312 LIRYLTVPYAP---TPRTAIEDSTVGDQVIKAGETVLCS-LPTANRDPALLPDADRLDVT 367 Query: 408 RFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHL-DLEL 466 R P ++ +G G +HCLG + A ++ + DL L Sbjct: 368 REAVP------------------HVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRL 409 Query: 467 INAD 470 + D Sbjct: 410 ADPD 413 >3TKT-A nrPDB Length = 450 Score = 80.3 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 66/485 (13%), Positives = 147/485 (30%), Gaps = 81/485 (16%) Query: 25 RRPGEPPLDLGSIPWLGYALDFGKD-AASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSY 83 R +P P L + + + ++H + + V+ Sbjct: 33 RAVIDPKSYGTWEPLLDRFDALRAEAPVAKVVAPDDEHEP---FWLVSSFDGVMKASKDN 89 Query: 84 DAVVWEPRTRLDFHAYAIFLMERIFDVQLPH--------YSPSDEKARMKLTLLHRELQA 135 + P++ + F +M + PH +P K R L Sbjct: 90 ATFLNNPKSTV-FTLRVGEMMAKAITGGSPHLVESLVQMDAPKHPKLR---RLTQDWFMP 145 Query: 136 LTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQ 195 A + +A + G E G DF L+ A Y ++ L E + + Sbjct: 146 KNLARLDGEIRKIANEAIDRMLGAGEEG--DFMA--LVAAPYPLHVVMQILGVPPEDEPK 201 Query: 196 DRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKW 255 + +F Q + + + + + + + RR + + Sbjct: 202 MLFLTQQMFGG--QDEDMNKSGLKDLPPEQISQIVAGAVAEFERYFAGLAAERRRNPTDD 259 Query: 256 LESYLL--HLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGEL 313 + + + ++ +S+ A ++ A ++ L L ++P+ A V+ + Sbjct: 260 VATVIANAVVDGEPMSDRDTAGYYIITASAGHDTTSASSAGAALALARDPDLFARVKADR 319 Query: 314 ESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLT-AAPFITREVVVDLAMPMADG 372 + ++ E++R T R D + Sbjct: 320 NLLPG-------------------------IVEEAIRWTTPVQHFMRTAATDTELCGQK- 353 Query: 373 REFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNM 432 + GD L+L +++ DP + +P F R N ++ Sbjct: 354 ----IAAGDWLMLN-YVAANHDPAQFPEPRKFDPTR------------------PANRHL 390 Query: 433 PWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDV 492 +GAG + CLG A ++ + ++L +D + + R + + Sbjct: 391 AFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGE-------PKRVNSTFVGGFKSL 443 Query: 493 PVRYR 497 P+R++ Sbjct: 444 PMRWK 448 >4RM4-A nrPDB Length = 396 Score = 79.5 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 47/331 (14%), Positives = 87/331 (26%), Gaps = 60/331 (18%) Query: 134 QALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQ 193 +A T + + E + D + F + + Sbjct: 98 KAFTPRVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVI----------SEL 147 Query: 194 AQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRS 253 + F + L PK + + L + +R Sbjct: 148 LGVPSAHMEQFKAWSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPE 207 Query: 254 KWLESYLLHLEEMG--VSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRG 311 + + S L+ EE G +S E L L A + +L+ P +R Sbjct: 208 QDIISILVEAEETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELR- 266 Query: 312 ELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMAD 371 ++ + E+LR A + R + + Sbjct: 267 ------------------------SHPELMPQAVEEALRFRAPAPVLRRIAKR----DTE 298 Query: 372 GREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYN 431 ++ GD +L F S RD + P +F R NP + Sbjct: 299 IGGHLIKEGDMVLAF-VASANRDEAKFDRPHMFDIRRHPNP------------------H 339 Query: 432 MPWGAGHNHCLGRSYAVNSIKQFVFLVLVHL 462 + +G G + CLG A + ++ Sbjct: 340 IAFGHGIHFCLGAPLARLEANIALTSLISAF 370 >1ODO-A nrPDB Length = 408 Score = 79.5 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 51/260 (19%), Positives = 89/260 (34%), Gaps = 56/260 (21%) Query: 226 DKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHL-----EEMGVSEEMQARALVLQ 280 D+ + +RL+++L A+RA + S L+ + +S E L+L Sbjct: 180 DQAEAQANTARLYEVLDQLIAAKRATPGDDMTSLLIAARDDEGDGDRLSPEELRDTLLLM 239 Query: 281 LWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPV 340 + A + LL P+ LA VR + W Sbjct: 240 ISAGYETTVNVIDQAVHTLLTRPDQLALVRK--GEVTWAD-------------------- 277 Query: 341 LDSVLSESLRLTAAP--FITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIY 398 V+ E+LR A R V D+A+P + RG+ +L + + R P+ + Sbjct: 278 ---VVEETLRHEPAVKHLPLRYAVTDIALPD----GRTIARGEPILAS-YAAANRHPDWH 329 Query: 399 TDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLV 458 D + F R + ++ +G G + CLG A + + + Sbjct: 330 EDADTFDATRTVKE------------------HLAFGHGVHFCLGAPLARMEVTLALESL 371 Query: 459 LVHL-DLELINADVEIPEFD 477 DL L + E+P Sbjct: 372 FGRFPDLRLADPAEELPPVP 391 >5CJE-A nrPDB Length = 393 Score = 79.1 bits (193), Expect = 4e-15, Method: Composition-based stats. Identities = 40/238 (16%), Positives = 70/238 (29%), Gaps = 51/238 (21%) Query: 228 DHMCSVKSRLWKLLSPARLARRAHR--SKWLESYLL--HLEEMGVSEEMQARALVLQLWA 283 D + RL L +R+ L + ++ +S E + L A Sbjct: 174 DAELAAYERLAAYLDELIDDKRSTAPADDLLGDLIRTRAEDDDRLSGEELRAMAFILLVA 233 Query: 284 TQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDS 343 + LL +P+ LAA+R +LD Sbjct: 234 GHETTVNLITNGVHTLLTHPDQLAALRA-------------------------DMTLLDG 268 Query: 344 VLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEV 403 + E LR A + + GD +++ + RDP + DP V Sbjct: 269 AVEEVLRFEGP---VETATYRYAAESMEIGGTAIAEGDPVMIG-LDAAGRDPARHPDPHV 324 Query: 404 FKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVH 461 F +R ++ +G G ++CLG A + + +L Sbjct: 325 FDIHR------------------APQGHLAFGHGIHYCLGAPLARLEARVALRSLLER 364 >1LG9-A nrPDB Length = 398 Score = 78.7 bits (192), Expect = 6e-15, Method: Composition-based stats. Identities = 36/274 (13%), Positives = 81/274 (29%), Gaps = 48/274 (17%) Query: 213 LLPKLARGSLSVGDKDHMCSV-KSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEE 271 + KL G L + + + L R + + ++ ++E Sbjct: 165 MFMKLCHGHLDASLSQKRRAALGDKFSRYLLAMIARERKEPGEGMIGAVVAEYGDDATDE 224 Query: 272 MQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLP 331 V + A N+ +L +L++P ++++ + Sbjct: 225 ELRGFCVQVMLAGDDNISGMIGLGVLAMLRHP-------EQIDAFRGDEQS--------- 268 Query: 332 QKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSP 391 + E +R P+ +A +++GD ++ + Sbjct: 269 ---------AQRAVDELIRYLTVPYSP---TPRIAREDLTLAGQEIKKGDSVICS-LPAA 315 Query: 392 QRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSI 451 RDP + D + R ++ +G G +HCLG + A + Sbjct: 316 NRDPALAPDVDRLDVTR------------------EPIPHVAFGHGVHHCLGAALARLEL 357 Query: 452 KQFVFLVLVHLDLELINADVEIPEFDLSRYGFGL 485 + + + + EF L+ +GL Sbjct: 358 RTVFTELWRRFPALRLADPAQDTEFRLTTPAYGL 391 >2WIO-A nrPDB Length = 431 Score = 78.4 bits (191), Expect = 7e-15, Method: Composition-based stats. Identities = 52/342 (15%), Positives = 90/342 (26%), Gaps = 64/342 (18%) Query: 124 MKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEM-GLLDFSYSFLLRAGYLTLYG 182 L A T ++L + + E L+D L L G Sbjct: 114 EHRALRKVVSSAFTPRTISDLEPRIRDVTRSLLADAGESFDLVDVLAFPLPVTIVAELLG 173 Query: 183 IEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLS 242 P HE D+ P + + D V + L L Sbjct: 174 --LPPMDHEQFGDWSGALVDIQMD-------DPTDPALAERIAD------VLNPLTAYLK 218 Query: 243 PARLARRAHRSKWLESYLLH--LEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL 300 RRA L S L+ ++ + +E A L A ++ L Sbjct: 219 ARCAERRADPGDDLISRLVLAEVDGRALDDEEAANFSTALLLAGHITTTVLLGNIVRTLD 278 Query: 301 KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE 360 ++P A + I +++ E LR Sbjct: 279 EHPAHWDAAAEDPGRIP-------------------------AIVEEVLRYRPP----FP 309 Query: 361 VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF 420 + + + D ++ LS RD + + DP+ F +R Sbjct: 310 QMQRTTTKATEVAGVPIPA-DVMVNTWVLSANRDSDAHDDPDRFDPSR------------ 356 Query: 421 YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHL 462 K + +G G + CLG A + + ++ Sbjct: 357 ----KSGGAAQLSFGHGVHFCLGAPLARLENRVALEEIIARF 394 >1Z8P-A nrPDB Length = 404 Score = 78.0 bits (190), Expect = 8e-15, Method: Composition-based stats. Identities = 39/243 (16%), Positives = 73/243 (30%), Gaps = 52/243 (21%) Query: 223 SVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEM---GVSEEMQARALVL 279 + + + + +L RR L S L+ +++ +S + ++ Sbjct: 179 PERAEQRGQAAREVVNFIL-DLVERRRTEPGDDLLSALIRVQDDDDGRLSADELTSIALV 237 Query: 280 QLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTP 339 L A + LL +P+ LA VR + LP Sbjct: 238 LLLAGFESSVSLIGIGTYLLLTHPDQLALVRR--------------DPSALPNA------ 277 Query: 340 VLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYT 399 + E LR A P E A + + + +L+ + RDP+ + Sbjct: 278 -----VEEILRYIAPP----ETTTRFAAEEVEIGGVAIPQYSTVLVANG-AANRDPKQFP 327 Query: 400 DPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVL 459 DP F R ++ +G G + C+GR A + + + Sbjct: 328 DPHRFDVTR------------------DTRGHLSFGQGIHFCMGRPLAKLEGEVALRALF 369 Query: 460 VHL 462 Sbjct: 370 GRF 372 >6GK6-A nrPDB Length = 411 Score = 77.2 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 38/247 (15%), Positives = 70/247 (28%), Gaps = 49/247 (19%) Query: 217 LARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLES--YLLHLEEMGVSEEMQA 274 L + + V ARR L S L +E +S + Sbjct: 175 LLAPAKDREFVERAQPVVEEFAAYFRALADARRKAPRDDLISGLLLAEEQEHKLSPAELS 234 Query: 275 RALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKV 334 + L L A +L LL +P + + Sbjct: 235 SMVFLLLVAGHETTVHLIASGMLLLLSHPAERRRL----DEDPG---------------- 274 Query: 335 LDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRD 394 ++ S + E+LR ++ + ++ + + G+ + L+ RD Sbjct: 275 -----LVGSAVEEALRCEGPAELS---TIRWSLEDIELFGARVPAGEGVAAG-LLAANRD 325 Query: 395 PEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQF 454 P+ + DP+ F R N ++ +G G + CLG A Sbjct: 326 PQHFPDPDRFDIGR------------------SPNRHIGFGGGIHFCLGAMLARIEAAIA 367 Query: 455 VFLVLVH 461 +L Sbjct: 368 FSTLLRR 374 >5IT1-A nrPDB Length = 399 Score = 77.2 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 66/426 (15%), Positives = 125/426 (29%), Gaps = 82/426 (19%) Query: 71 GRYVTVLLDPHSYDAVVWEPRTRLDFHAYA-----IFLMERIFDVQLPHYSPS--DEKAR 123 G ++ AV+ +P + + + L +P D++ Sbjct: 42 GHEAWLVTGYEQVRAVLRDPSFSVGVPHALHTQDGVVTQKPGRGSLLWQDAPEHTDDRKL 101 Query: 124 MKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGI 183 + R +QAL N+ ++ + + L+ + + L+G+ Sbjct: 102 LAKEFTVRRMQALRP----NIQRIVDEHLDAIEARGGPVDLVKTFANPVPSMVISDLFGV 157 Query: 184 EALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSP 243 A R + + + D D + RL LL Sbjct: 158 PAERRAEFQEIAEAMMRVD----------------------QDAAATEAAGMRLGGLLYQ 195 Query: 244 ARLARRAHRSKWLESYLLHLEE-MGVSEEMQARALVLQLW-ATQGNMGPAAFWLLLFLLK 301 RRA+ L S L+ E+ GV ++M L A LL Sbjct: 196 LVQERRANPGDDLISALITTEDPDGVIDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLD 255 Query: 302 NPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREV 361 P+ LA ++ + S++ A + E LR E Sbjct: 256 RPDQLALLQKD-PSLIGNA------------------------VEELLRYLTIGQFGAE- 289 Query: 362 VVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFY 421 +A + + +G+++ + LS DP DPE F R Sbjct: 290 --RVATQDGEIGGVRIAKGEQV-VTHLLSADFDPAFVEDPERFDITR------------- 333 Query: 422 KDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRY 481 ++ +G G + C+G+ A ++ + + VE F Sbjct: 334 -----RPAPHLAFGFGAHQCIGQQLARIELQIVFGTLFRRFPTLRLAKPVEELRFRNDMV 388 Query: 482 GFGLMQ 487 +G+ + Sbjct: 389 FYGVHE 394 >5OFQ-A nrPDB Length = 409 Score = 76.8 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 53/371 (14%), Positives = 116/371 (31%), Gaps = 70/371 (18%) Query: 121 KARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL 180 + + R +Q L E + LL + + + +++ L L Sbjct: 95 RNLVNKAFTPRAIQHL-EGHIEEIADYLLDEVSSK----EKFDIVEDFAGPLPIIVIAEL 149 Query: 181 YGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKL 240 G+ R + D + S ++ +++ L Sbjct: 150 LGVPIQDRALFKKYSDDLVSGAENNSDEAFAKMM-------------QKRNEGVIFLQGY 196 Query: 241 LSPARLARRAHRSKWLESYLLH--LEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLF 298 R+ ++ + L S LL ++ ++EE +L L A + + Sbjct: 197 FKEIIAERQQNKQEDLISLLLEAEIDGEHLTEEEVLGFCILLLVAGNETTTNLITNGVRY 256 Query: 299 LLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFIT 358 + ++ + VR ++ + +++ E+LR Sbjct: 257 MTEDVDVQNEVRRDISLVP-------------------------NLVEETLRYYPP---- 287 Query: 359 REVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKK 418 + + +A + E ++RG +++ + S RD + P+ F +R NP Sbjct: 288 IQAIGRIAAEDVELGECKIKRGQQVISWAA-SANRDSAKFEWPDTFVVHRKTNP------ 340 Query: 419 DFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDL 478 ++ +G G + CLG A K +L + + D Sbjct: 341 ------------HVSFGFGIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQ-SLKPID- 386 Query: 479 SRYGFGLMQPE 489 S + FG+ + E Sbjct: 387 SPFVFGVKKYE 397 >4YZR-A nrPDB Length = 405 Score = 76.1 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 78/450 (17%), Positives = 142/450 (31%), Gaps = 91/450 (20%) Query: 42 YALDFGKDAASFLTRMKEKHG-DIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYA 100 + +F + S L R +E+ F + G L D + + R+ Sbjct: 9 HGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPAWLITRYDDCMAFLKDNRI--TRDV 66 Query: 101 IFLMER--------------IFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHA 146 +M + + D L +P + R + QA T NL Sbjct: 67 KNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHTRLRSLVH------QAFTPRTIENLRG 120 Query: 147 VLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHT 206 + A + + D SF ++ + E + E ++Q ++ + + T Sbjct: 121 SIEQIAEQLLDEMEKENKADIMKSFASPLPFIVI--SELMGIPKEDRSQFQIWTNAMVDT 178 Query: 207 FRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEM 266 S G+++ ++ RR L S L+H EE Sbjct: 179 ----------------SEGNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKLVHAEEN 222 Query: 267 G--VSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPV 324 G +SE+ L L + A L LL++ + ++ + E I Sbjct: 223 GSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIA------- 275 Query: 325 SQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLL 384 + + E LR T+ + A+ + +++RGD + Sbjct: 276 ------------------TAVEELLRYTSPVVMMAN---RWAIEDFTYKGHSIKRGDMIF 314 Query: 385 LFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGR 444 + S RDP + +PE+ NR N ++ +G G + CLG Sbjct: 315 IG-IGSANRDPNFFENPEILNINR------------------SPNRHISFGFGIHFCLGA 355 Query: 445 SYAVNSIKQFVFLVLVHL-DLELINADVEI 473 A +L D+EL A +I Sbjct: 356 PLARLEGHIAFKALLKRFPDIELAVAPDDI 385 >4YT3-A nrPDB Length = 410 Score = 76.1 bits (185), Expect = 4e-14, Method: Composition-based stats. Identities = 42/258 (16%), Positives = 79/258 (30%), Gaps = 53/258 (20%) Query: 210 LDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLH--LEEMG 267 +D L R DK + K ++ L P + +R + + + S LL ++ Sbjct: 169 VDTLFLPFDREKQEEVDKLKQVAAKE-YYQYLYPIVVQKRLNPADDIISDLLKSEVDGEM 227 Query: 268 VSEEMQARALVLQLWATQGNMGPAAFWLLLFLL-KNPEALAAVRGELESILWQAEQPVSQ 326 +++ R +L L A LL + E + L+ + Sbjct: 228 FTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDLVP--------- 278 Query: 327 TTTLPQKVLDSTPVLDSVLSESLRLTAAPF-ITREVVVDLAMPMADGREFNLRRGDRLLL 385 + E LR + R V D + + +E GD +++ Sbjct: 279 ----------------QAVEEMLRFRFNLIKLDRTVKEDNDLLGVELKE-----GDSVVV 317 Query: 386 FPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRS 445 + + D E++ DP +R ++ +G G + CLG Sbjct: 318 W-MSAANMDEEMFEDPFTLNIHR-----------------PNNKKHLTFGNGPHFCLGAP 359 Query: 446 YAVNSIKQFVFLVLVHLD 463 A K + L Sbjct: 360 LARLEAKIALTAFLKKFK 377 >6G5O-A nrPDB Length = 399 Score = 75.7 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 41/269 (15%), Positives = 89/269 (33%), Gaps = 53/269 (19%) Query: 222 LSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLE--EMGVSEEMQARALVL 279 + + L+ + + + S LL+ E +++E +VL Sbjct: 157 FRSEGEALDGDKANILYHYIDEQIDRASENPGDDMYSVLLNSEFEGRKLTKEEVKGVMVL 216 Query: 280 QLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTP 339 + + A + +L ++PEAL +R E E Sbjct: 217 TFAGGRDTVINAVTNSIAYLAEHPEALERLRKEPE------------------------- 251 Query: 340 VLDSVLSESLR-LTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIY 398 + + E +R + + R V D + + D + + S RD ++ Sbjct: 252 ITGRAVEEMIRYFSPLTQMGRVVTEDTHVCEHAV------KADSRISLCWASANRDAAVF 305 Query: 399 TDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLV 458 +P +R +NP ++ +G H++CLG ++A +K + + Sbjct: 306 ENPNEIVLDRKVNP------------------HVGFGFSHHNCLGATHARQILKILLQTL 347 Query: 459 LVHL-DLELINADVEIPEFDLSRYGFGLM 486 + E+++ I + D + G Sbjct: 348 AQKVASFEILDYKENIEDLDHFQRKVGFH 376 >6FYJ-A nrPDB Length = 421 Score = 75.7 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 60/459 (13%), Positives = 125/459 (27%), Gaps = 83/459 (18%) Query: 52 SFLTRMKEKHG---DIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIF 108 ++ + +H DIF + G+ + + + + ++ A +++ +F Sbjct: 25 GYMYILNRRHSFNSDIFETRLLGKKAICMGGKEAAE-IFYDTEKFKRKDAAPNRVVQTLF 83 Query: 109 DVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMG---LL 165 K + ++ L + A W +M L Sbjct: 84 GKNGVQALDGQTHKHRKEMFMS----IMSPDELEKLTDITKKQWEIAVDKWEQMDKVILY 139 Query: 166 DFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVG 225 + + + R + +E + + A + A L Sbjct: 140 EEAKEIMCRTACQW---AGVPVQENEVKRLTKNLGA-----------MFESAAAVGLKHW 185 Query: 226 DKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEM---GVSEEMQARALVLQLW 282 H + + + L + + + + + + A V+ + Sbjct: 186 LGRHARNYEEIWIEELIDRVRDGKVNPPENTTLHKFSWYRDLEGNLLDTETAAVEVINIL 245 Query: 283 ATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLD 342 + ++ L L PE ++ Sbjct: 246 RPIVAIAIFINFIALALHHYPEEKEKLKS------------------------GDKKYSQ 281 Query: 343 SVLSESLRLTAA-PFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDP 401 + E R PF+ V D + + G LL DPEI+ +P Sbjct: 282 MFVQEVRRFYPFFPFVVALVKKDFTW-----KGYKFEEGTLTLLD-LYGTNHDPEIWKNP 335 Query: 402 EVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGH----NHCLGRSYAVNSIKQFVFL 457 +VF +RF +GS +P G G + C G + +K + Sbjct: 336 DVFSPDRFAKWEGS------------PFSFIPQGGGDYFMGHRCAGEWVTIEVMKVSLDY 383 Query: 458 VLVHLDLELINADVEIPEFDLS-RYGFGLMQPEHDVPVR 495 + +D E+ P+ DLS P V ++ Sbjct: 384 LTNRMDYEV-------PDQDLSFSMASMPSIPHSKVVIK 415 >3RWL-A nrPDB Length = 426 Score = 75.7 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 29/216 (13%), Positives = 71/216 (32%), Gaps = 47/216 (21%) Query: 248 RRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALA 307 + + + ++ E ++L + + +L L KNP+ A Sbjct: 230 NKDPGNDLISMLAHSPATRNMTPEEYLGNVLLLIVGGNDTTRNSMTGGVLALHKNPDQFA 289 Query: 308 AVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAM 367 ++ + ++++++ E +R R A+ Sbjct: 290 KLKA-------------------------NPALVETMVPEIIRWQTPLAHMR----RTAI 320 Query: 368 PMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRL 427 ++ +R+GD+++++ + S RD E+ PE F +R Sbjct: 321 ADSELGGKTIRKGDKVVMW-YYSGNRDDEVIDRPEEFIIDR-----------------PR 362 Query: 428 KNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLD 463 ++ +G G + C+G A ++ +L Sbjct: 363 PRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFS 398 >3P3Z-A nrPDB Length = 416 Score = 75.3 bits (183), Expect = 5e-14, Method: Composition-based stats. Identities = 43/275 (15%), Positives = 92/275 (33%), Gaps = 57/275 (20%) Query: 226 DKDHMCSVKSRL---WKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVL-QL 281 D+D + V+ L + L A R+ L S ++ GV ++ + R LV L Sbjct: 192 DQDILVKVEQGLGRMFDYLVAAIEKRKVEPGDDLTSDIVRAFHDGVLDDYELRTLVATVL 251 Query: 282 WATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVL 341 A + ++P+ ++ + + Sbjct: 252 VAGYETTNHQLALAMYDFAQHPDQWMKIKE-------------------------NPELA 286 Query: 342 DSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDP 401 + E LR + +T +A + + G + + ++ RDP ++ D Sbjct: 287 PQAVEEVLRWSPTLPVTAT---RVAAEDFEVNGVRIPTGTPVFMCAHVA-HRDPRVFADA 342 Query: 402 EVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVH 461 + F + + ++ +G G + CLG + A + + V + Sbjct: 343 DRFD-----------------ITVKREAPSIAFGGGPHFCLGTALARLELTEAVAALATR 385 Query: 462 LDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRY 496 LD I ++ R+ G+ P+ +P+R+ Sbjct: 386 LDPPQIAGEI------TWRHELGVAGPDA-LPLRF 413 >1EHE-A nrPDB Length = 403 Score = 75.3 bits (183), Expect = 6e-14, Method: Composition-based stats. Identities = 50/399 (12%), Positives = 105/399 (26%), Gaps = 72/399 (18%) Query: 93 RLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDA 152 L + F P +++ ++ T + NL + Sbjct: 71 ELSASGKQAAKAKPTFVDMDPPEH-MHQRSMVEPTFTPEAV--------KNLQPYIQRTV 121 Query: 153 TEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDR 212 + + G G L + + + F L+ Sbjct: 122 DDLLEQMKQKG---------------CANGPVDLVKEFALPVPSYIIYTLLGVPFNDLEY 166 Query: 213 LLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYL--LHLEEMGVSE 270 L + A + + L L+ R + S L ++ + + Sbjct: 167 LTQQNAIRTNGSSTAREASAANQELLDYLAILVEQRLVEPKDDIISKLCTEQVKPGNIDK 226 Query: 271 EMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTL 330 + L L A M + L ++P+ LA ++ Sbjct: 227 SDAVQIAFLLLVAGNATMVNMIALGVATLAQHPDQLAQLKA------------------- 267 Query: 331 PQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLS 390 + + + E R A + + A + +R + ++ S Sbjct: 268 ------NPSLAPQFVEELCRYHTASAL---AIKRTAKEDVMIGDKLVRANEGIIASNQ-S 317 Query: 391 PQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNS 450 RD E++ +P+ F NR P + +G G + C+ A Sbjct: 318 ANRDEEVFENPDEFNMNRKWPPQDP----------------LGFGFGDHRCIAEHLAKAE 361 Query: 451 IKQFVFLVLVHL-DLELINADVEIPEFDLSRYGFGLMQP 488 + + DL++ +I L+R + P Sbjct: 362 LTTVFSTLYQKFPDLKVAVPLGKINYTPLNRDVGIVDLP 400 >3TYW-A nrPDB Length = 417 Score = 74.9 bits (182), Expect = 8e-14, Method: Composition-based stats. Identities = 43/265 (16%), Positives = 86/265 (32%), Gaps = 49/265 (18%) Query: 223 SVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLL--HLEEMGVSEEMQARALVLQ 280 + + L+ LL RR L S L+ HL V+ E L + Sbjct: 187 RNSTAEQVSEALGGLFGLLGGLVAERREEPRDDLISKLVTDHLVPGNVTTEQLLSTLGIT 246 Query: 281 LWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPV 340 + A + L LL PE A +R + + + Sbjct: 247 INAGRETTTSMIALSTLLLLDRPELPAELRKDPD-------------------------L 281 Query: 341 LDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTD 400 + + + E LR+ + + + + +A + + D ++ DPE + D Sbjct: 282 MPAAVDELLRVLS---VADSIPLRVAAEDIELSGRTVPADDGVIAL-LAGANHDPEQFDD 337 Query: 401 PEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLV 460 PE ++R N+++ +G G + C+G+ A ++ + +L Sbjct: 338 PERVDFHR------------------TDNHHVAFGYGVHQCVGQHLARLELEVALETLLR 379 Query: 461 HLDLELINADVEIPEFDLSRYGFGL 485 + + + + FGL Sbjct: 380 RVPTLRLAGERDQVVVKHDSATFGL 404 >3R9C-A nrPDB Length = 418 Score = 74.5 bits (181), Expect = 9e-14, Method: Composition-based stats. Identities = 45/257 (17%), Positives = 78/257 (30%), Gaps = 52/257 (20%) Query: 227 KDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMG--VSEEMQARALVLQLWAT 284 D L L RR + L S L+ +EE G ++E+ L L A Sbjct: 198 FDEQMKAGMWLRDYLRALIDERRRTPGEDLMSGLVAVEESGDQLTEDEIIATCNLLLIAG 257 Query: 285 QGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSV 344 L +L+ P AA+ + +V Sbjct: 258 HETTVNLIANAALAMLRTPGQWAALAADGSR-------------------------ASAV 292 Query: 345 LSESLRL-TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEV 403 + E++R ++R DL + + +GD +LL + RDP I P+ Sbjct: 293 IEETMRYDPPVQLVSRYAGDDLTI-----GTHTVPKGDTMLLL-LAAAHRDPTIVGAPDR 346 Query: 404 FKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLD 463 F +R + ++ +G G + CLG A + + Sbjct: 347 FDPDR------------------AQIRHLGFGKGAHFCLGAPLARLEATVALPALAARFP 388 Query: 464 LELINADVEIPEFDLSR 480 ++ + E R Sbjct: 389 EARLSGEPEYKRNLTLR 405 >2Y5N-A nrPDB Length = 417 Score = 74.5 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 45/267 (16%), Positives = 84/267 (31%), Gaps = 52/267 (19%) Query: 230 MCSVKSRLWKLLSPARLARRAHRSKWLESYLL--HLEEMGVSEEMQARALVLQLWATQGN 287 M + + + RR + L S L+ ++ +SE+ + L A + Sbjct: 199 MQEAAEQAYAYMGDLIDRRRKEPTDDLVSALVQARDQQDSLSEQELLDLAIGLLVAGYES 258 Query: 288 MGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSE 347 + L+ PE + LD ++ S + E Sbjct: 259 TTTQIADFVYLLMTRPELRRQL-------------------------LDRPELIPSAVEE 293 Query: 348 SLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYN 407 R P A+ R +R G+ +L + RD + D + + Sbjct: 294 LTRW--VPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTG-AANRDQAQFPDADRIDVD 350 Query: 408 RFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELI 467 R N ++ +G G +HCLG A ++ + ++L L Sbjct: 351 R------------------TPNQHLGFGHGVHHCLGAPLARVELQVALEVLLQR----LP 388 Query: 468 NADVEIPEFDLSRYGFGLMQPEHDVPV 494 + IPE L L++ ++PV Sbjct: 389 GIRLGIPETQLRWSEGMLLRGPLELPV 415 >5Y1I-A nrPDB Length = 403 Score = 74.1 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 58/388 (14%), Positives = 124/388 (31%), Gaps = 73/388 (18%) Query: 76 VLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIF-DVQLPHYSPSDEKARMKLTLLHRELQ 134 +L DP + + + + + + F P + + + L R ++ Sbjct: 56 LLSDPRVSHDGLRDGYPHISADFKFLSMAQPSFAGQDDPEHG--RIRRMVTLPFTARRIE 113 Query: 135 ALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQA 194 A+ A+ ++ G +G + L++ + + G+ R Q Sbjct: 114 AMRPAIQKITDELIDG----MLAGPKPVDLVEALALPVPVRVICEMLGVPYEDREFLQQN 169 Query: 195 QDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSK 254 + + D D ++ K L +L R Sbjct: 170 NNAMIYRDTAQG-------------------DAQKAAIAQAMYLKELVGTKLGDRG--DD 208 Query: 255 WLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELE 314 L + +E ++++ A ++ L A L LL+NPE LA VR Sbjct: 209 ILSDLAVQVEAGEITQDDAAGIGMMLLGAGHETTANMIALGTLALLENPEQLAEVR---- 264 Query: 315 SILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGRE 374 + P+ +++ + E LR I ++ V +A + Sbjct: 265 ------------DSDDPKVIVN-------TVEELLRYLT---IAQDTVRRIAAEDIEIGG 302 Query: 375 FNLRRGDRLLLFPFLSPQRDPEIYTD-PEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMP 433 ++ G+ + +FP + DP++Y + P+ +R ++ Sbjct: 303 VVIKAGEGI-VFPLNAANWDPDLYPEAPDRLDIHR-----------------ANARRHLA 344 Query: 434 WGAGHNHCLGRSYAVNSIKQFVFLVLVH 461 +G G + CLG + A ++ +L Sbjct: 345 FGYGVHQCLGATLARVELQIVYSTLLRR 372 >5XJN-A nrPDB Length = 455 Score = 74.1 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 52/350 (14%), Positives = 100/350 (28%), Gaps = 70/350 (20%) Query: 113 PHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLG----DATEAGSGWHEMG-LLDF 167 + S + +A T Y L + + + +G ++ Sbjct: 131 AYSGLSARIPPEHTRIRAIAQKAFTPRRYKALEPDIRAMVIDRVEKMLANDQHVGDMVSD 190 Query: 168 SYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDK 227 + LTL G + + D + G LS ++ Sbjct: 191 LAYDIPTITILTLIGADISMVDTYKRWSDSRA----------------AMTWGDLSDEEQ 234 Query: 228 DHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMG--VSEEMQARALVLQLWATQ 285 W+ AH L + L+ ++ G +++ A L L+A Sbjct: 235 IPHAHNLVEYWQECQRMVADAHAHGGDNLTADLVRAQQEGQEITDHEIASLLYSLLFAGH 294 Query: 286 GNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVL 345 LL +PE A+ L++ ++ + + Sbjct: 295 ETTTTLISNCFRVLLDHPEQWQAI-------------------------LENPKLIPAAV 329 Query: 346 SESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFK 405 E LR + + R A+ + ++ GD +LL S RD + + E F Sbjct: 330 DEVLRYSGSIVGWR----RKALKDTEIGGVAIKEGDGVLLLMG-SANRDEARFENGEEFD 384 Query: 406 YNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFV 455 +R ++ +G G ++CLG A K + Sbjct: 385 ISR-----------------ANAREHLSFGFGIHYCLGNMLAKLQAKICL 417 >5GWE-A nrPDB Length = 405 Score = 74.1 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 52/350 (14%), Positives = 100/350 (28%), Gaps = 70/350 (20%) Query: 113 PHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLG----DATEAGSGWHEMG-LLDF 167 + S + +A T Y L + + + +G ++ Sbjct: 81 AYSGLSARIPPEHTRIRAIAQKAFTPRRYKALEPDIRAMVIDRVEKMLANDQHVGDMVSD 140 Query: 168 SYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDK 227 + LTL G + + D + G LS ++ Sbjct: 141 LAYDIPTITILTLIGADISMVDTYKRWSDSRA----------------AMTWGDLSDEEQ 184 Query: 228 DHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMG--VSEEMQARALVLQLWATQ 285 W+ AH L + L+ ++ G +++ A L L+A Sbjct: 185 IPHAHNLVEYWQECQRMVADAHAHGGDNLTADLVRAQQEGQEITDHEIASLLYSLLFAGH 244 Query: 286 GNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVL 345 LL +PE A+ L++ ++ + + Sbjct: 245 ETTTTLISNCFRVLLDHPEQWQAI-------------------------LENPKLIPAAV 279 Query: 346 SESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFK 405 E LR + + R A+ + ++ GD +LL S RD + + E F Sbjct: 280 DEVLRYSGSIVGWR----RKALKDTEIGGVAIKEGDGVLLLMG-SANRDEARFENGEEFD 334 Query: 406 YNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFV 455 +R ++ +G G ++CLG A K + Sbjct: 335 ISR-----------------ANAREHLSFGFGIHYCLGNMLAKLQAKICL 367 >4JBT-A nrPDB Length = 410 Score = 74.1 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 58/353 (16%), Positives = 102/353 (28%), Gaps = 74/353 (20%) Query: 115 YSPSDEKARMKLT--LLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFL 172 P + R+K T L R L AL + A LL D AG+ + L L Sbjct: 95 DGPEHRRLRIKTTQALTRRRLDALKPTI-ERYVAELLDDLERAGADGAVVDLKSVFAYPL 153 Query: 173 LRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCS 232 L G+ E Q Q F +D Sbjct: 154 PMRVISALMGVP-----SEDQEQLLTWYKAFFSILTP-----------------QDERLR 191 Query: 233 VKSRLWKLLSPARLARRAHRSKWLESYLLHLE--EMGVSEEMQARALVLQLWATQGNMGP 290 V + + + A L S L++ E ++EE L + A Sbjct: 192 VIDEMHGYFTEMVRRKTAEPGDDLTSALIYATDGETPLTEEEVIGNLQALVAAGHETTVS 251 Query: 291 AAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLR 350 + LL +PE L VR + + ++ + E+LR Sbjct: 252 LILTAVRALLSHPEQLRLVR---DGEIGW----------------------ETAIEETLR 286 Query: 351 LTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYT-DPEVFKYNRF 409 +++ A D + + RG+ +++ + + RD ++ D + F R Sbjct: 287 WDGPVI---HLLMRFATEDIDLGDAVIPRGEGVVMS-YRAIGRDITVHGADADDFDITRA 342 Query: 410 LNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHL 462 ++ +G G + C G + A + + Sbjct: 343 TAAR-----------------HISFGHGPHICPGAALARLEAAIALPALFTRF 378 >6HQG-A nrPDB Length = 425 Score = 73.7 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 56/416 (13%), Positives = 112/416 (26%), Gaps = 71/416 (17%) Query: 49 DAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIF 108 D + E G +++ + V + V+ + A +F Sbjct: 48 DPVHWGVSPHEDVGGYWSVTKYNDIMAVDTNHE-----VFSSEPTIVLPDPADDFTLPMF 102 Query: 109 DVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFS 168 P K + L ++ A + +++ Sbjct: 103 IAMDPPKHDVQRKTV---------QPIVAPNHLAYLEPIIRERAGKILDDLPIGEEINWV 153 Query: 169 YSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKD 228 + +TL + P + A L P+ +L Sbjct: 154 DKVSIELTTMTLATLFDFPWEDRRKLTFWSDVATSAPESGILGTTDPE-EHENLRRQTLF 212 Query: 229 HMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMG-VSEEMQARALVLQLWATQGN 287 RLW A L S L H E + L+L + Sbjct: 213 ECVDYFMRLW------NERVNAPPKPDLISMLAHGESTKNMDRMEYLGNLILLIVGGNDT 266 Query: 288 MGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSE 347 +L L +NP+ +R + ++ +++SE Sbjct: 267 TRNTISGSVLALHQNPDQDRKLRE-------------------------NPGLIPAMVSE 301 Query: 348 SLRL-TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKY 406 ++R T ++ R D + +R GD++ ++ ++S RD E+ P + Sbjct: 302 TIRWQTPLAYMRRRAKRDFEL-----GGKTIREGDKVAMW-YVSGNRDEEVIDRPNDYWI 355 Query: 407 NRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHL 462 R ++ +G G + C+G A +K +L Sbjct: 356 ER-----------------PRVRQHLSFGFGVHRCVGNRLAELQLKIIWEEILARF 394 >5YHJ-A nrPDB Length = 413 Score = 73.7 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 72/472 (15%), Positives = 140/472 (29%), Gaps = 83/472 (17%) Query: 40 LGYALDFGKDAASFLTRMKEKH-GDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHA 98 L +++DF ++ F+ ++ +IF + G V L + + V ++ A Sbjct: 11 LDHSVDFLREGYLFVANRRKSFQSNIFESRLLGERVICLGGEEAAE-VFYDANKFTRQDA 69 Query: 99 YAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSG 158 L++ +F E K + +T+ L + + + Sbjct: 70 APKRLLKTLFGEGGVQTLDGSEHTHRKQMFMS----LMTKENIDRLLRLTYREWNQIERM 125 Query: 159 WHEMGLLDFSYSFLLRAGY----LTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLL 214 E+ L D + L++A + L E RT E + ++ Sbjct: 126 GEEIVLYDIAQEVLMKAVCEWSGVPLAKEEVGKRTEEMRLLFESGTS------------- 172 Query: 215 PKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARR-AHRSKWLESYLLHLEEMG-VSEEM 272 G + + S + + +++ R R + L + H +E G + E Sbjct: 173 ----LGPTYLQGRKARSSAEVWIRQMVKEVRSNRLLPNEHTALYEFSWHRDESGELLPEE 228 Query: 273 QARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAV-RGELESILWQAEQPVSQTTTLP 331 VL + + + +L L + P+ V RGE+ Sbjct: 229 VVAVEVLNILRPTVAISVYVLFTVLALHQFPDVKEQVERGEVSKT--------------- 273 Query: 332 QKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSP 391 + E R V + + G LL Sbjct: 274 -----------EFVQEVRRFYP----FFPVAAARVKTDFEWDGYAFPEGTLTLLD-LYGT 317 Query: 392 QRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGH----NHCLGRSYA 447 D I+T+P+ F +RF KD K +P G G + C G Sbjct: 318 NHDVSIWTEPDRFDPSRF------------KDWKESPFNFIPQGGGDVDFGHRCAGEHVT 365 Query: 448 VNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 499 + + Q + L + D+ D+ P+ + + + R Sbjct: 366 IAILAQVIELFTKEYAYTVPPQDLSYSFVDMPSL------PKSKLRLTHLTR 411 >3OFT-A nrPDB Length = 396 Score = 73.4 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 58/344 (16%), Positives = 97/344 (28%), Gaps = 75/344 (21%) Query: 117 PSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDF---SYSFLL 173 P + ++ L L + A + G DF L Sbjct: 86 PLQQDGAEHKAFRTPVMKGLASRFVVALEPKVQAVARKLMESLRPRGSCDFVSDFAEILP 145 Query: 174 RAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSV 233 +LTL + R Q ++ D T QL + Sbjct: 146 LNIFLTLIDVPLEDRPRLRQLGVQLTRPDGSMTVEQL-------------------KQAA 186 Query: 234 KSRLWKLLSPARLARRAHRSKWLESYLLH--LEEMGVSEEMQARALVLQLWATQGNMGPA 291 LW P R A L S +L + + + R L+ + Sbjct: 187 DDYLW----PFIEKRMAQPGDDLFSRILSEPVGGRPWTVDEARRMCRNLLFGGLDTVAAM 242 Query: 292 AFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL 351 + L L ++PE +R + I A+ E +R Sbjct: 243 IGMVALHLARHPEDQRLLRERPDLIPAAAD-------------------------ELMRR 277 Query: 352 TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLN 411 ++R V D+ D +R+GD + L P + DP + PE +++R L Sbjct: 278 YPTVAVSRNAVADV-----DADGVTIRKGDLVYL-PSVLHNLDPASFEAPEEVRFDRGLA 331 Query: 412 PDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFV 455 P + G G + C+G A + F+ Sbjct: 332 PIR----------------HTTMGVGAHRCVGAGLARMEVIVFL 359 >4TRI-A nrPDB Length = 407 Score = 73.4 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 45/279 (16%), Positives = 85/279 (30%), Gaps = 55/279 (19%) Query: 220 GSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLL--HLEEMGVSEEMQARAL 277 + + + + RRA + L S L+ +E +S++ Sbjct: 168 SHVDEAAIQKLMDTFAAYTEFTKDVITKRRAEPTDDLFSVLVNSEVEGQRMSDDEIVFET 227 Query: 278 VLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDS 337 +L L LL++ + A+ +++ + Sbjct: 228 LLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVDLLPGA------------------ 269 Query: 338 TPVLDSVLSESLRLT-AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPE 396 + E LR T + R + D + LR G++++L F S D Sbjct: 270 -------IEEMLRWTSPVKNMCRTLTADTVFHGTE-----LRAGEKIMLM-FESANFDES 316 Query: 397 IYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVF 456 ++ DP+ F+ +R N ++ +G G + CLG A ++ Sbjct: 317 VFGDPDNFRIDR------------------NPNSHVAFGFGTHFCLGNQLARLELRLMTE 358 Query: 457 LVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVR 495 VL L + D +P L F V Sbjct: 359 RVLRRLPDLRLADDAPVP---LRPANFVSGPESMPVVFT 394 >5XNT-A nrPDB Length = 411 Score = 73.4 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 49/352 (13%), Positives = 93/352 (26%), Gaps = 69/352 (19%) Query: 115 YSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLR 174 P K R L A T N + A E E +D S Sbjct: 92 DPPEHRKRRSLLAA------AFTPRSLQNWEPRIQEIADELIEEMDEETEIDIVQSLASP 145 Query: 175 AGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVK 234 + + + +P + V F D+ + Sbjct: 146 LPIIVMSDLMGVPSKDRLLFKKWVDIL-----FLPFDK--------EKQEEVNELKQVAA 192 Query: 235 SRLWKLLSPARLARRAHRSKWLESYLLH--LEEMGVSEEMQARALVLQLWATQGNMGPAA 292 ++ L P + +R + + + S LL ++ +++ R +L L A Sbjct: 193 KEYYQYLYPIVVQKRLNPADDIISDLLKAEVDGEMFTDDEVVRTTMLILGAGVETTSHLL 252 Query: 293 FWLLLFLL-KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL 351 LL + E + L+ + Q + + LD + E Sbjct: 253 ANSFYSLLYDDKEVYQELHENLDLVP--------QAVEEMLRYRFNLIKLDRTVKE---- 300 Query: 352 TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLN 411 D L+ G+ ++++ + D E++ D +R Sbjct: 301 -----------------DNDLLGVELKEGENVVVW-MSAANLDEEMFEDAFTLNIHR--- 339 Query: 412 PDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLD 463 ++ +G G + CLG A K + L Sbjct: 340 --------------PNNKKHLTFGNGPHFCLGAPLARLEAKIALTTFLKKFK 377 >5FOI-A nrPDB Length = 408 Score = 73.0 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 38/241 (15%), Positives = 75/241 (31%), Gaps = 50/241 (20%) Query: 223 SVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLL--HLEEMGVSEEMQARALVLQ 280 S + D L + L + AH L + L + ++ + VL Sbjct: 185 SRPNDDRSMPALIELVEYLDGLVRTKTAHPDTGLLGTAVTERLLKGEITHQELVNNAVLL 244 Query: 281 LWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPV 340 L A +L LL++PE A +R + E + Sbjct: 245 LAAGHETSANQVTLSVLTLLRHPETAAELREQPE-------------------------L 279 Query: 341 LDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTD 400 + + + E LR + + + A + +R GD L++ S D + Sbjct: 280 MPNAVDELLRYHS----IADGLRRAATADIVLGDHTIRAGDGLIIL-LSSANHDGNTFGA 334 Query: 401 PEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLV 460 F +R +++ +G G + CLG++ A ++ + + Sbjct: 335 EATFDIHR------------------PARHHVAFGYGPHQCLGQNLARLEMEVTLGKLFR 376 Query: 461 H 461 Sbjct: 377 R 377 >6GMF-A nrPDB Length = 397 Score = 73.0 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 55/341 (16%), Positives = 101/341 (29%), Gaps = 68/341 (19%) Query: 125 KLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIE 184 L +A T L + A E G + + + + + E Sbjct: 87 HGKLRTLVTKAFTPRTVAQLEPRIRDIAHELVDGLRGKSTFEATVEVTVPMPMIVI--AE 144 Query: 185 ALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPA 244 L E +A + S D+ + + VG+ + + S Sbjct: 145 MLGVAPERRADFKRWSDDMVGSLA------------LVRVGNAAQLERSTQEFYAYFSEV 192 Query: 245 RLARRAHRSKWLESYLLH--LEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKN 302 RR + L S LL ++ ++ L A L+ L + Sbjct: 193 LEERRREPREDLISQLLAAEVDGEKLTAGEVLSFANTLLIAGNETTTSLIGNALVALTDH 252 Query: 303 PEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPF-ITREV 361 PE LAA + +L + +V+ E LR + I R+ Sbjct: 253 PEQLAAAQADLSLVP-------------------------AVVEEVLRYESPAQCIFRQT 287 Query: 362 VVDLAMPMADGREFNLRRGDRLLLFPFL-SPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF 420 + D+ + + R ++ P L S RD + DP+ F +R Sbjct: 288 MTDVEIGDE-----RIPA--RSVVLPLLASANRDESRFPDPDRFDIHR------------ 328 Query: 421 YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVH 461 ++ +G + C+G A K + ++L Sbjct: 329 ------DTKGHLAFGLDIHFCIGAPLARLEAKVMLEVLLAR 363 >5LIV-A nrPDB Length = 450 Score = 72.6 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 56/372 (15%), Positives = 104/372 (27%), Gaps = 71/372 (19%) Query: 98 AYAIFLMERIFDVQLPH----YSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDAT 153 R+F + + DE ARM+ L + Sbjct: 104 RDTATFSTRMFQAGILNGGLAAMQGDEHARMRRVYNMFFLPRAVSQYEERFVRPISEQVV 163 Query: 154 EAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRL 213 + +G + LL+ L R L+G + + T ++ + Sbjct: 164 DRLAGKPRVDLLEDFAMELPRRVIGELFG---------------FPAEKLHETDERVRAM 208 Query: 214 LPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLH--LEEMGVSEE 271 L L R L++ S L +L E + E Sbjct: 209 LRGLVRMHDPAAV-AESQRAYGETLGLITEVVERESRDTSDTLLGEILRTLKAEHMDTIE 267 Query: 272 MQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLP 331 + ++ + + LL +P+ LA VR + Sbjct: 268 ASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQDPS----------------- 310 Query: 332 QKVLDSTPVLDSVLSESLRLTAAPF-ITREVVVDLAMPMADGREFNLRRGDRLLLFPFLS 390 +L + + E +R + F + R V D+ + L G ++ ++ Sbjct: 311 --------LLPAAIEEGMRWCPSSFGVLRMVERDVRLDDQA-----LSAGT-VVCLAGIA 356 Query: 391 PQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNS 450 D Y PEV+ +R K L N+ +G G + C+G A Sbjct: 357 GNYDETAYPSPEVYDIDR----------------KPLPAANV-FGGGAHFCVGAPLARME 399 Query: 451 IKQFVFLVLVHL 462 + + +L Sbjct: 400 ARVGLQALLARF 411 >4OQS-A nrPDB Length = 433 Score = 72.6 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 41/277 (14%), Positives = 89/277 (32%), Gaps = 56/277 (20%) Query: 224 VGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWA 283 +D + + +L + ++ +R L L+ + +++E +L L A Sbjct: 183 DKTQDEVTTALGKLTRYIAELVATKRLSPKDDLLGSLI--TDTDLTDEELTNIALLLLVA 240 Query: 284 TQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDS 343 LL++PE +AA+ P V + L Sbjct: 241 GHETTANMLGLGTFALLQHPEQIAAL-------------------DSPDAVEELLRYLSI 281 Query: 344 VLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEV 403 V R + D+ + +R+GD + + + RDP+++ +P++ Sbjct: 282 V--------HLGTPNRAALEDVEL-----EGQMIRKGDTVAIG-LPAVNRDPKVFDEPDI 327 Query: 404 FKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLD 463 + +R + +G G + CLG+ A ++ + Sbjct: 328 LQLDR-----------------VDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFP 370 Query: 464 LELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP 500 + E + +G+ +PV + RP Sbjct: 371 SLRLAVPAEEIKLREKSAAYGVWA----LPVAWDARP 403 >2ZQJ-A nrPDB Length = 417 Score = 72.6 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 62/432 (14%), Positives = 132/432 (30%), Gaps = 75/432 (17%) Query: 48 KDAASFLTRMKEKH-GDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMER 106 K+ F+ E++ D+F + G+ + + V ++ +A + + Sbjct: 19 KEGYLFIKNRTERYNSDLFQARLLGKNFICMTGAEA-AKVFYDTDRFQRQNALPKRVQKS 77 Query: 107 IFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGW---HEMG 163 +F V K+ L +T L ++ + A + W E+ Sbjct: 78 LFGVNAIQGMDGSAHIHRKMLFLS----LMTPPHQKRLAELMTEEWKAAVTRWEKADEVV 133 Query: 164 LLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLS 223 L + + L R G+ + +A D + D F + AR Sbjct: 134 LFEEAKEILCRVACYWA-GVPLKETEVKERADDFIDMVDAFGAVGPRHWK-GRRARPRAE 191 Query: 224 VGDKDHMCSVKSRLWKLLS----PARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVL 279 + + ++ L K S L+S + +E + V + A + L Sbjct: 192 EWIEVMIEDARAGLLKTTSGTALHEMAFHTQEDGSQLDSRMAAIELINVLRPIVAISYFL 251 Query: 280 QLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTP 339 + L L ++P+ +R + + Sbjct: 252 V-------------FSALALHEHPKYKEWLRS------GNSRER---------------- 276 Query: 340 VLDSVLSESLRLTA-APFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIY 398 + + E R PF+ V D + + +G +LL DP ++ Sbjct: 277 --EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFK-----KGTSVLLD-LYGTNHDPRLW 328 Query: 399 TDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGH----NHCLGRSYAVNSIKQF 454 P+ F+ RF + + +P G GH + C G + +K Sbjct: 329 DHPDEFRPERFAEREENL------------FDMIPQGGGHAEKGHRCPGEGITIEVMKAS 376 Query: 455 VFLVLVHLDLEL 466 + ++ ++ ++ Sbjct: 377 LDFLVHQIEYDV 388 >6B11-A nrPDB Length = 440 Score = 72.2 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 38/213 (17%), Positives = 67/213 (31%), Gaps = 48/213 (22%) Query: 249 RAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAA 308 R L S + G+S VL L A +L LL++P A Sbjct: 245 RESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMSVLVLLQHPTAWRE 304 Query: 309 VRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMP 368 + + +L + E LR + + A Sbjct: 305 L-------------------------TVNPGLLPGAVDELLRY----LSIADGLRRSATA 335 Query: 369 MADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLK 428 + +R GD L +F + RD ++++PE F +R Sbjct: 336 DIEIDGHTIRAGDGL-VFLLAAANRDEAVFSEPEAFDIHR------------------SA 376 Query: 429 NYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVH 461 ++ +G G + CLG++ A ++ + VL Sbjct: 377 RRHVAFGYGPHQCLGQNLARMELEVALGAVLER 409 >6FSH-A nrPDB Length = 398 Score = 72.2 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 41/274 (14%), Positives = 81/274 (29%), Gaps = 48/274 (17%) Query: 213 LLPKLARGSLSVGDKDHMCSV-KSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEE 271 + KL G L + + + L R ++ +++E Sbjct: 165 MFMKLCHGHLDASLSQKRRAALGDKFSRYLLAMIARERKDPGDGFIGSIVAEHGDTITDE 224 Query: 272 MQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLP 331 V + A N+ +L LL++PE +AA+RG+ +S Sbjct: 225 ELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQS---------------- 268 Query: 332 QKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSP 391 D + E +R P+ A+ + ++ G+ +L Sbjct: 269 ---------ADRAVDELIRYLTVPYAP---TPRTAVEDVMVADQVIKEGETVLCS-LPMA 315 Query: 392 QRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSI 451 RD + D + R ++ +G G +HCLG + + Sbjct: 316 NRDRALLPDADRLDVTR------------------TPVPHVAFGHGIHHCLGAALTRLQL 357 Query: 452 KQFVFLVLVHLDLELINADVEIPEFDLSRYGFGL 485 + + + + F S +GL Sbjct: 358 RIAYTALWRRFPALQLADPAQEIMFRTSTPAYGL 391 >2RCM-A nrPDB Length = 495 Score = 72.2 bits (175), Expect = 5e-13, Method: Composition-based stats. Identities = 39/214 (18%), Positives = 79/214 (36%), Gaps = 21/214 (9%) Query: 257 ESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKN-----PEALAAVRG 311 L+ +++G+S E L L+AT N L ++K + + Sbjct: 267 GEILVEADKLGISREEATHNL---LFATCFNTWGGMKILFPNMVKRIGRAGHQVHNRLAE 323 Query: 312 ELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMAD 371 E+ S++ L ++ + SV+ E LR + + Sbjct: 324 EIRSVIKSN------GGELTMGAIEKMELTKSVVYECLRFEPPVTAQYGRAKKDLVIESH 377 Query: 372 GREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSE--KKDFYKDGKRLKN 429 F ++ G+ L + L+ RDP+I+ + F RF+ +G + + + +G + Sbjct: 378 DAAFKVKAGEMLYGYQPLAT-RDPKIFDRADEFVPERFVGEEGEKLLRHVLWSNGPETET 436 Query: 430 YNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLD 463 + G+ C G+ + V + FV + D Sbjct: 437 PTV----GNKQCAGKDFVVLVARLFVIEIFRRYD 466 >6F88-A nrPDB Length = 400 Score = 71.8 bits (174), Expect = 6e-13, Method: Composition-based stats. Identities = 56/372 (15%), Positives = 104/372 (27%), Gaps = 71/372 (19%) Query: 98 AYAIFLMERIFDVQLPH----YSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDAT 153 R+F + + DE ARM+ L + Sbjct: 54 RDTATFSTRMFQAGILNGGLAAMQGDEHARMRRVYNMFFLPRAVSQYEERFVRPISEQVV 113 Query: 154 EAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRL 213 + +G + LL+ L R L+G + + T ++ + Sbjct: 114 DRLAGKPRVDLLEDFAMELPRRVIGELFG---------------FPAEKLHETDERVRAM 158 Query: 214 LPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLH--LEEMGVSEE 271 L L R L++ S L +L E + E Sbjct: 159 LRGLVRMHDPAAV-AESQRAYGETLGLITEVVERESRDTSDTLLGEILRTLKAEHMDTIE 217 Query: 272 MQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLP 331 + ++ + + LL +P+ LA VR + Sbjct: 218 ASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQDPS----------------- 260 Query: 332 QKVLDSTPVLDSVLSESLRLTAAPF-ITREVVVDLAMPMADGREFNLRRGDRLLLFPFLS 390 +L + + E +R + F + R V D+ + L G ++ ++ Sbjct: 261 --------LLPAAIEEGMRWCPSNFGVLRMVERDVRLDDQA-----LSAGT-VVCLAGIA 306 Query: 391 PQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNS 450 D Y PEV+ +R K L N+ +G G + C+G A Sbjct: 307 GNYDETAYPSPEVYDIDR----------------KPLPAANV-FGGGAHFCVGAPLARME 349 Query: 451 IKQFVFLVLVHL 462 + + +L Sbjct: 350 ARVGLQALLARF 361 >4TX3-A nrPDB Length = 404 Score = 71.8 bits (174), Expect = 7e-13, Method: Composition-based stats. Identities = 37/258 (14%), Positives = 75/258 (29%), Gaps = 47/258 (18%) Query: 228 DHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGN 287 + + L R ++ +++E V + A N Sbjct: 187 RKRAAAGEAFARYLVAMMARERKDPGDGFIGSIVAEHGDTITDEELRGVCVQLMLAGDDN 246 Query: 288 MGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSE 347 + +L LL++PE +AA+RG+ +S D + E Sbjct: 247 VSGMIGLGVLALLRHPEQIAALRGDDQS-------------------------ADRAVDE 281 Query: 348 SLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYN 407 +R P+ A+ + ++ G+ +L RD + D + Sbjct: 282 LIRYLTVPYAP---TPRTAVEDVMVADQVIKEGETVLCS-LPMANRDRALLPDADRLDVT 337 Query: 408 RFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELI 467 R ++ +G G +HCLG + ++ + + Sbjct: 338 R------------------TPVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQL 379 Query: 468 NADVEIPEFDLSRYGFGL 485 + F S +GL Sbjct: 380 ADPAQEIMFRTSTPAYGL 397 >4Z5P-A nrPDB Length = 400 Score = 71.8 bits (174), Expect = 7e-13, Method: Composition-based stats. Identities = 41/238 (17%), Positives = 80/238 (33%), Gaps = 48/238 (20%) Query: 227 KDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLL--HLEEMGVSEEMQARALVLQLWAT 284 K+ S + + L+ ARRA L L+ ++ ++E+ V L A Sbjct: 179 KEEAVSADASIRAYLADLVSARRAAPHDDLLGVLVSARDDDDRLTEDELITFGVTLLVAG 238 Query: 285 QGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSV 344 ++ LL + + L+ +R + E +L Sbjct: 239 HETSAHQLGNMVYALLTHEDQLSLLREQPE-------------------------LLPRA 273 Query: 345 LSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVF 404 + E LR P +A+ + +R G+ + + ++ RDP + DP+ Sbjct: 274 VEELLRF--VPLGNGVGNARIALEDVELSGGTVRAGEGV-VAAAVNANRDPRAFDDPDRL 330 Query: 405 KYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHL 462 R NP ++ +G G ++CLG A ++ + +L Sbjct: 331 DITREKNP------------------HLAFGHGAHYCLGAQLARMELRVAIGGLLERF 370 >6A7J-A nrPDB Length = 411 Score = 71.0 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 41/238 (17%), Positives = 77/238 (32%), Gaps = 51/238 (21%) Query: 240 LLSPARLARRAHRSKWLESYLLHLEEMG--VSEEMQARALVLQLWATQGNMGPAAFWLLL 297 L + ++A+ L S L+ E G +++E L L + A ++ Sbjct: 195 LFTKIVEEKKANPGDDLTSALIAASEDGDHLTDEEILNTLQLIIAAGHETTISLIVNVVE 254 Query: 298 FLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFI 357 L +PE V + P + V+ E+LR Sbjct: 255 ALAIHPEQRKKV------------------------LSGEIPW-EGVIEETLRWNTP--- 286 Query: 358 TREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIY-TDPEVFKYNRFLNPDGSE 416 T V++ A + + L +G+ L++ F + RD E Y F R Sbjct: 287 TSHVLIRFATEDIEVGDKVLPKGEGLVVS-FGALGRDEEQYGPTAGDFDATR-------- 337 Query: 417 KKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHL-DLELINADVEI 473 N ++ +G G + C G + + + + +L+L E+ Sbjct: 338 ----------TPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPAAEL 385 >5L1U-A nrPDB Length = 401 Score = 70.7 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 44/254 (17%), Positives = 77/254 (30%), Gaps = 44/254 (17%) Query: 218 ARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARAL 277 ARG+ D +H + ++ + +R + S L+ ++ +S+ A Sbjct: 170 ARGTFDQSDNEHSANTFQQVVDYMLELVARKRVEPGDDILSELIAEKDGALSDADIAHLG 229 Query: 278 VLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDS 337 L L LL+NP A E P Sbjct: 230 NAVLLFGYETTIVRIDLGTLLLLRNP-VQRAQLAE-----DPGLAP-------------- 269 Query: 338 TPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEI 397 + + E LRL + ++ A E +R GD ++L + D Sbjct: 270 -----AAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLA-IGAANYDDRA 323 Query: 398 YTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFL 457 + D +F R ++ +G G HC+GR+ A + Sbjct: 324 FPDGGLFDLTR-----------------VRPRSHLAFGHGARHCIGRTLARIELTAVFER 366 Query: 458 VLVHL-DLELINAD 470 + L DL L + Sbjct: 367 LFRRLPDLRLAVPE 380 >2Z36-A nrPDB Length = 413 Score = 70.3 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 43/277 (15%), Positives = 88/277 (31%), Gaps = 53/277 (19%) Query: 222 LSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEE-MGVSEEMQARALVLQ 280 +S + + L + + + L S + + G + +L Sbjct: 182 VSRTSMEDRRRAFAELRAYIDDLITRKESEPGDDLFSRQIARQRQEGTLDHAGLVSLAFL 241 Query: 281 LW-ATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTP 339 L A ++ LL +PE L V+ P Sbjct: 242 LLTAGHETTANMISLGVVGLLSHPEQLTVVKA------NPGRTP---------------- 279 Query: 340 VLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYT 399 + E LR I V LA + +++ G+ +++ LS DP ++ Sbjct: 280 ---MAVEELLRYFT---IADGVTSRLATEDVEIGGVSIKAGEGVIVS-MLSANWDPAVFK 332 Query: 400 DPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVL 459 DP V R +++ +G G + CLG++ A ++ + Sbjct: 333 DPAVLDVER------------------GARHHLAFGFGPHQCLGQNLARMELQIVFDTLF 374 Query: 460 VHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRY 496 + + + +P D+ G ++ H++PV + Sbjct: 375 RR----IPSLRLAVPMEDVPFKGDSVIYGVHELPVTW 407 >3ABB-A nrPDB Length = 408 Score = 70.3 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 36/228 (15%), Positives = 78/228 (34%), Gaps = 50/228 (21%) Query: 236 RLWKLLSPARLARRAHRSK-WLESYLLHLEEMG-VSEEMQARALVLQLWATQGNMGPAAF 293 L+ L ++A L+ + E G + + ++ L A A Sbjct: 194 ELYTYLHGLVGRKQAEPEDGLLDELIARQLEEGDLDHDEVVMIALVLLVAGHETTVNAIA 253 Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTA 353 L L+++PE + + + ++ V+ E LR T+ Sbjct: 254 LGALTLIQHPEQIDVLLRDPGAVSG-------------------------VVEELLRFTS 288 Query: 354 APFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPD 413 + +V +A + ++ GD +L+ L RD + Y +P++F R Sbjct: 289 VS----DHIVRMAKEDIEVGGATIKAGDAVLVSITLM-NRDAKAYENPDIFDARR----- 338 Query: 414 GSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVH 461 +++ +G G + CLG++ A ++ + + Sbjct: 339 -------------NARHHVGFGHGIHQCLGQNLARAELEIALGGLFAR 373 >3DBM-A nrPDB Length = 473 Score = 70.3 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 68/457 (14%), Positives = 151/457 (33%), Gaps = 62/457 (13%) Query: 47 GKDAASFLTRMKEKHGDIFTILVGG-------RYVTVLLDPHSYDAVVWEPRTRL--DFH 97 G+D F +RM++ +F + V VLLD S+ + + F Sbjct: 35 GRDEY-FRSRMQKYQSTVFRANMPPGPFVSSNPKVIVLLDAKSFPILFDVSKVEKKDLFT 93 Query: 98 AYAIFLMERIFDV-QLPHYSPSDEKARMKLTLLHRELQALTEAM-------YTNLHAVLL 149 + + L + PS+ + LL L+ + + YT L L Sbjct: 94 GTYMPSTKLTGGYRVLSYLDPSEPRHAQLKNLLFFMLKNSSNRVIPQFETTYTELFEGLE 153 Query: 150 GDATEAGSGW----HEMGLLDFSYSFLLRA-GYLTLYGIEALPRTHESQAQDRVHSADVF 204 + + G E F + T G A + + D+ Sbjct: 154 AELAKNGKAAFNDVGEQAAFRFLGRAYFNSNPEETKLGTSAPTLISSWVLFNLAPTLDLG 213 Query: 205 HTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLE 264 + + + S ++L+ + E Sbjct: 214 LPW------FLQEPLLHTFRLPAFLIKSTYNKLYDYF-----------QSVATPVMEQAE 256 Query: 265 EMGVSEEMQARALVLQL-WATQGNMGP----AAFWLLLFLLKNPEALAAVRGELESILWQ 319 ++GV ++ ++ + + T G + W+ L A + +L + + Sbjct: 257 KLGVPKDEAVHNILFAVCFNTFGGVKILFPNTLKWIGL-------AGENLHTQLAEEI-R 308 Query: 320 AEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-TAAPFITREVVVDLAMPMADGREFNLR 378 + + ++ P+ SV+ ESLR+ P + + + D F ++ Sbjct: 309 GAIKSYGDGNVTLEAIEQMPLTKSVVYESLRIEPPVPPQYGKAKSNFTIESHDAT-FEVK 367 Query: 379 RGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFL-NPDGSEKKDFYKDGKRLKNYNMPWGAG 437 +G+ L + + +DP+++ PE + +RF+ + + K ++ +G ++ + Sbjct: 368 KGEMLFGYQPFAT-KDPKVFDRPEEYVPDRFVGDGEALLKYVWWSNGPETESPTV----E 422 Query: 438 HNHCLGRSYAVNSIKQFVFLVLVHLD-LELINADVEI 473 + C G+ + V + FV + D E+ + + Sbjct: 423 NKQCAGKDFVVLITRLFVIELFRRYDSFEIELGESPL 459 >6F0B-A nrPDB Length = 395 Score = 69.9 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 34/260 (13%), Positives = 82/260 (31%), Gaps = 53/260 (20%) Query: 234 KSRLWKLLSPARLARRAHRSKWLESYLLHL------EEMGVSEEMQARALVLQLWATQGN 287 + +++ L S+ E L+ +E ++ +++ + Sbjct: 178 GAEVFRTLGEYIGGLVQDPSELPEDSLIRRLVTGPYQEKQLTFHETIGVILMLIVGGYDT 237 Query: 288 MGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSE 347 L+ PE + V E I P+L + E Sbjct: 238 TASTISLSLVSYALQPEKFSVVHEHPERI----------------------PLL---VEE 272 Query: 348 SLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYN 407 LR + + +A + +R G ++ L+ RD ++ +P+ ++ Sbjct: 273 LLRYHTVSQLG---LGRIATEDVEVGGVTVRAGQMVVAALPLA-NRDESVFPNPDELDFD 328 Query: 408 RFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELI 467 R ++ +G G + C+G++ A +++ + V+ L + Sbjct: 329 R------------------PSVPHVGFGYGPHQCVGQALARVELQEAIPAVIRRLPGMRL 370 Query: 468 NADVEIPEFDLSRYGFGLMQ 487 +E F +G+ + Sbjct: 371 ACALEDLPFRHDMATYGIHE 390 >1Q5D-A nrPDB Length = 419 Score = 69.9 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 55/301 (18%), Positives = 97/301 (32%), Gaps = 60/301 (19%) Query: 201 ADVFHTFRQL----DRLLPKLARGSLSVGDKDHMCSVKSRLWKL---LSPARLARRAHRS 253 A+ FR+ R L + K + SV L L L R R + Sbjct: 166 AECDEKFRRFGSATARALGVGLVPRVDEETKTLVASVTEGLALLHGVLDERR--RNPLEN 223 Query: 254 KWLESYLLH-LEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGE 312 L L + +S + + + A + +L LL++PEAL V+ E Sbjct: 224 DVLTMLLQAEADGSRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAE 283 Query: 313 LESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADG 372 ++ + L E LR I R V A + Sbjct: 284 ----PG---------------------LMRNALDEVLRFDN---ILRIGTVRFARQDLEY 315 Query: 373 REFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNM 432 ++++G+ + L S RD +++ P+VF R + ++ Sbjct: 316 CGASIKKGEMVFLL-IPSALRDGTVFSRPDVFDVRR------------------DTSASL 356 Query: 433 PWGAGHNHCLGRSYAVNSIKQFVFLVLVHL-DLELINADV--EIPEFDLSRYGFGLMQPE 489 +G G + C G S A + V + +++L V P F +++P Sbjct: 357 AYGRGPHVCPGVSLARLEAEIAVGTIFRRFPEMKLKETPVFGYHPAFRNIESLNVILKPS 416 Query: 490 H 490 Sbjct: 417 K 417 >6CVC-A nrPDB Length = 433 Score = 68.7 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 64/391 (16%), Positives = 103/391 (26%), Gaps = 67/391 (17%) Query: 70 GGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMER----IFDVQLPHYSPSDEKARMK 125 G+ L P I F + P ++ R Sbjct: 69 AGKGHWALTKHDDIHFASRHPEIFHSSPNIVIHDQTPELAEYFGSMIVLDDPRHQRLR-- 126 Query: 126 LTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEA 185 +++ R A A H G D AG L L I Sbjct: 127 -SIVSRAFTPKVVARIEASVRERAHRLVAAMIENHPDGQADLVSEL---AGPLPLQIICD 182 Query: 186 LPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPAR 245 + E + H +V F P L + + + L+ R Sbjct: 183 MMGIPEEDHEQIFHWTNVILGFG-----DPDL---TTDFDEFLQVSMAIGGYATALADDR 234 Query: 246 LARRAHRSKWLESYLLH-LEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPE 304 R H S + ++ +S A +L + A A +L L + P+ Sbjct: 235 --RVNHHGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNAISHGMLALSRYPD 292 Query: 305 ALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVD 364 A + + + A + E +R + R + Sbjct: 293 ERAKWWSDFDGLAATA------------------------VEEIVRWASPVVYMRRTLS- 327 Query: 365 LAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDG 424 D R + GD++ L+ + S RD E + DP F R NP Sbjct: 328 ---QDVDLRGTKMAAGDKVTLW-YCSANRDEEKFADPWTFDVTRNPNPQVGFG------- 376 Query: 425 KRLKNYNMPWGAGHNHCLGRSYAVNSIKQFV 455 G G + CLG + A I+ Sbjct: 377 ----------GGGAHFCLGANLARREIRVVF 397 >6A7I-A nrPDB Length = 411 Score = 68.7 bits (166), Expect = 6e-12, Method: Composition-based stats. Identities = 48/264 (18%), Positives = 85/264 (32%), Gaps = 54/264 (20%) Query: 235 SRLWKLLSPARLARRAHRSKWLESYLLHLEEMG--VSEEMQARALVLQLWATQGNMGPAA 292 + L L + A+R + L S L+ E G +++E L L + A Sbjct: 190 ADLGALFTKIVDAKRTNPGDDLTSALIAASENGDHLTDEEIVNTLQLIIAAGHETTISLI 249 Query: 293 FWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLT 352 ++ L +PE V L + D V+ E+LR Sbjct: 250 VNVVEALQTHPEQRKKV---LNGEIGW----------------------DGVIEETLRWN 284 Query: 353 AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIY-TDPEVFKYNRFLN 411 T V++ A + + L +G+ L++ F + RD E Y F R Sbjct: 285 TP---TSHVLIRFATEDIEVGDKILPKGEGLIIS-FGALGRDEEQYGPTAGEFDATR--- 337 Query: 412 PDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADV 471 N ++ +G G + C G + + + + D+ Sbjct: 338 ---------------TPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERFP----ELDL 378 Query: 472 EIPEFDLSRYGFGLMQPEHDVPVR 495 +P DL H++PV+ Sbjct: 379 AVPASDLRNKPIVTQNDLHELPVK 402 >2ZBZ-A nrPDB Length = 412 Score = 68.7 bits (166), Expect = 6e-12, Method: Composition-based stats. Identities = 53/418 (12%), Positives = 119/418 (28%), Gaps = 86/418 (20%) Query: 56 RMKEKHGDIFTILVG-GRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQ--- 111 ++++ G + + + GR V+ + ++ +PR + F+ Sbjct: 32 QLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPAFEAVRES 91 Query: 112 ----LPHYSPS--DEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLL 165 + P + + ++ + + +H L E + L+ Sbjct: 92 PQAFIGLDPPEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFL----DEMLAAGPTADLV 147 Query: 166 DFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVG 225 + L G+ A R+ + Sbjct: 148 SQFALPVPSMVICRLLGVPYADHEFFQDASKRL-----------------------VQST 184 Query: 226 DKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLL--HLEEMGVSEEMQARALVLQLWA 283 D + ++ L L + L L+ L + E +L L A Sbjct: 185 DAQSALTARNDLAGYLDGLITQFQTEPGAGLVGALVADQLANGEIDREELISTAMLLLIA 244 Query: 284 TQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDS 343 ++ LL +PE AA+R + + Sbjct: 245 GHETTASMTSLSVITLLDHPEQYAALRADRSLVPGA------------------------ 280 Query: 344 VLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEV 403 + E LR A I +A + +R G+ +++ ++ RD +Y DP+ Sbjct: 281 -VEELLRYLAIADIAGG---RVATADIEVEGQLIRAGEGVIVVNSIA-NRDGTVYEDPDA 335 Query: 404 FKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVH 461 +R +++ +G G + CLG++ A ++ + ++ Sbjct: 336 LDIHR------------------SARHHLAFGFGVHQCLGQNLARLELEVILNALMDR 375 >4OQR-A nrPDB Length = 457 Score = 68.3 bits (165), Expect = 6e-12, Method: Composition-based stats. Identities = 35/262 (13%), Positives = 82/262 (31%), Gaps = 52/262 (19%) Query: 224 VGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWA 283 +D + + +L + ++ +R L L+ + +++E ++ L A Sbjct: 222 DKTQDEVTTALGKLTRYIAELVATKRLSPKDDLLGSLI--TDTDLTDEELTNIALILLVA 279 Query: 284 TQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDS 343 LL++PE +A + P V + L Sbjct: 280 GHETTANMLGLGTFALLQHPEQIANL-------------------DSPDAVEELLRYLSI 320 Query: 344 VLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEV 403 V R + D+ + +R+GD + + + RDP+++ +P++ Sbjct: 321 V--------HLGTPNRAALEDVEL-----EGQMIRKGDTVAIG-LPAVNRDPKVFDEPDI 366 Query: 404 FKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLD 463 + +R + +G G + CLG+ A ++ + Sbjct: 367 LQLDR-----------------VDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFP 409 Query: 464 LELINADVEIPEFDLSRYGFGL 485 + E + +G+ Sbjct: 410 SLRLAVPAEEIKLREKSAAYGV 431 >3ABA-A nrPDB Length = 403 Score = 68.3 bits (165), Expect = 6e-12, Method: Composition-based stats. Identities = 46/266 (17%), Positives = 83/266 (31%), Gaps = 49/266 (18%) Query: 224 VGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEE-MGVSEEMQARALVLQLW 282 D + RL LL RRA+ L S L+ E+ GV ++M L Sbjct: 176 DQDAAATEAAGMRLGGLLYQLVQERRANPGDDLISALITTEDPDGVVDDMFLMNAAGTLL 235 Query: 283 -ATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVL 341 A LL +P+ LA +R + ++ Sbjct: 236 IAAHDTTACMIGLGTALLLDSPDQLALLREDPS-------------------------LV 270 Query: 342 DSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDP 401 + + E LR E +A + + +G+++ + L+ DP +P Sbjct: 271 GNAVEELLRYLTIGQFGGE---RVATRDVELGGVRIAKGEQV-VAHVLAADFDPAFVEEP 326 Query: 402 EVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVH 461 E F R ++ +G G + C+G+ A ++ + Sbjct: 327 ERFDITR------------------RPAPHLAFGFGAHQCIGQQLARIELQIVFETLFRR 368 Query: 462 LDLELINADVEIPEFDLSRYGFGLMQ 487 L + VE F +G+ + Sbjct: 369 LPGLRLAKPVEELRFRHDMVFYGVHE 394 >5LIE-A nrPDB Length = 414 Score = 68.3 bits (165), Expect = 6e-12, Method: Composition-based stats. Identities = 36/248 (14%), Positives = 77/248 (31%), Gaps = 53/248 (21%) Query: 220 GSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVL 279 + + ++ SRL+ +RA + + S + + + A + Sbjct: 185 SRRATMPRLNVEDAGSRLYTYALELIAGKRAEPADDMLSVVANATIDDPDAPALSDAELY 244 Query: 280 QLW-----ATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKV 334 + A + LL L +NP+ L +R + E Sbjct: 245 LFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFE-------------------- 284 Query: 335 LDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRD 394 +L + + E +R T+ R + G +++++ S RD Sbjct: 285 -----LLPTAIEEIVRWTSPSPSKRRTASR----AVSLGGQPIEAGQKVVVWEG-SANRD 334 Query: 395 PEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQF 454 P ++ + F R N ++ +G G ++CLG + A ++ Sbjct: 335 PSVFDRADEFDITR------------------KPNPHLGFGQGVHYCLGANLARLELRVL 376 Query: 455 VFLVLVHL 462 +L Sbjct: 377 FEELLSRF 384 >3WVS-A nrPDB Length = 401 Score = 68.3 bits (165), Expect = 7e-12, Method: Composition-based stats. Identities = 39/230 (16%), Positives = 74/230 (32%), Gaps = 48/230 (20%) Query: 234 KSRLWKLLSPARLARRAHRSKWLESYLL--HLEEMGVSEEMQARALVLQLWATQGNMGPA 291 + L + ARRA + L S ++ + ++E+ + L A Sbjct: 190 RMELVGYIGGIIAARRAQPADDLISGMIEARDVQDKLTEQELLDHCIGLLIAGHETTASQ 249 Query: 292 AFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL 351 + LL P+ + LD ++ S + E R Sbjct: 250 IPSFVYALLDQPQHWKRL-------------------------LDDPELIPSAVEELFRF 284 Query: 352 TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLN 411 P + A + +R G+ +L+ + RD + DPE K +R Sbjct: 285 --VPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVALG-AANRDGLRFEDPEEIKLDR--- 338 Query: 412 PDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVH 461 N+++ +G G +HCLG A +++ + +L Sbjct: 339 ---------------PSNHHIGFGHGIHHCLGAPLARLELQEALRALLER 373 >3A50-A nrPDB Length = 411 Score = 68.0 bits (164), Expect = 9e-12, Method: Composition-based stats. Identities = 46/329 (13%), Positives = 91/329 (27%), Gaps = 70/329 (21%) Query: 134 QALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQ 193 ++ T L + A +G G +D + + + Sbjct: 104 RSFTVRRMNELEPRITEIADGLLAGLPTDGPVDLMREYAFQIPVQVI------------- 150 Query: 194 AQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRS 253 + A+ F +L + D + +L LS +R Sbjct: 151 CELLGLPAEDRDDFSAWSSVL-------VDDSPADDKNAAMGKLHGYLSDLLERKRTEPD 203 Query: 254 KWLESYLLH---LEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVR 310 L S LL ++ +S+E +L L A +L LL +P+ + Sbjct: 204 DALLSSLLAVSDMDGDRLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPD-QRKLL 262 Query: 311 GELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMA 370 E S++ A + E LR + + + Sbjct: 263 AEDPSLISSA------------------------VEEFLRFDSP---VSQAPIRFTAEDV 295 Query: 371 DGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNY 430 + G+ ++L + RD + +P+ R + G Sbjct: 296 TYSGVTIPAGEMVMLG-LAAANRDADWMPEPDRLDITR--DASGG--------------- 337 Query: 431 NMPWGAGHNHCLGRSYAVNSIKQFVFLVL 459 + +G G + CLG A + + + Sbjct: 338 -VFFGHGIHFCLGAQLARLEGRVAIGRLF 365 >2XKR-A nrPDB Length = 398 Score = 68.0 bits (164), Expect = 9e-12, Method: Composition-based stats. Identities = 55/362 (15%), Positives = 105/362 (29%), Gaps = 59/362 (16%) Query: 145 HAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYL--TLYGIEALPRTHESQAQDRVH-SA 201 ++ T E + + + + + + D + Sbjct: 87 RKLVNAGFTRKRVKDKEASIAALCDTLIDAVCERGECDFVRDLAAPLPMAVIGDMLGVRP 146 Query: 202 DVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLL 261 + F + L +S D + ARRA + L S L+ Sbjct: 147 EQRDMFLRWSDDLVTFLSSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDLVSVLV 206 Query: 262 --HLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQ 319 ++ +S++ +L L LL+N + ++ + + Sbjct: 207 SSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDPSLLPGA 266 Query: 320 AEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRR 379 + E LR TA + + + + L Sbjct: 267 -------------------------IEEMLRWTAP----VKNMCRVLTADTEFHGTALCA 297 Query: 380 GDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHN 439 G++++L F S D ++ +PE F R N ++ +G G + Sbjct: 298 GEKMMLL-FESANFDEAVFCEPEKFDVQR------------------NPNSHLAFGFGTH 338 Query: 440 HCLGRSYAVNSIKQFVFLVLVHL-DLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRI 498 CLG A + VL L DL L+ D +P + + GL +PV + Sbjct: 339 FCLGNQLARLELSLMTERVLRRLPDLRLVADDSVLP-LRPANFVSGL----ESMPVVFTP 393 Query: 499 RP 500 P Sbjct: 394 SP 395 >6G71-A nrPDB Length = 405 Score = 68.0 bits (164), Expect = 9e-12, Method: Composition-based stats. Identities = 37/225 (16%), Positives = 69/225 (30%), Gaps = 50/225 (22%) Query: 228 DHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGN 287 + L L SYLL + + E + + + Sbjct: 181 AKAKQSSDEIDAALEEMIQWHSGRPGDSLLSYLLRSADYQMPLESIRSNIKMTIGGG--- 237 Query: 288 MGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSE 347 E +L + + ++ + VL + +V E Sbjct: 238 ----------------------LNEPRDVLGVSTLALLSSSKQLELVLRDPKLWGAVFEE 275 Query: 348 SLR-LTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKY 406 S+R + + R+ VVD + + + RG +L L LS RD +++DP+ F Sbjct: 276 SIRWVAPIGMVPRQTVVDTELD-----GYFIPRGAKLGLC-ILSANRDRSVWSDPDRFDI 329 Query: 407 NRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSI 451 R ++ +G G + CLG A + + Sbjct: 330 ER------------------GSEAHLAFGKGVHVCLGAWAARSQV 356 >3MGX-A nrPDB Length = 415 Score = 68.0 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 45/269 (16%), Positives = 87/269 (32%), Gaps = 59/269 (21%) Query: 232 SVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPA 291 + + ARR L S L+ +++ + + + L A Sbjct: 205 QAHTEILVYFDELITARRKEPGDDLVSTLVTDDDLTIDDVLL--NCDNVLIGGNETTRHA 262 Query: 292 AFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL 351 + L P L A+R + D+V+ E LR Sbjct: 263 ITGAVHALATVPGLLTALRDGSADV-------------------------DTVVEEVLRW 297 Query: 352 TAAPF-ITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFL 410 T+ + R D+ + D L G ++ + + RDP + DP+ F R Sbjct: 298 TSPAMHVLRVTTADVTINGRD-----LPSGTPVVAW-LPAANRDPAEFDDPDTFLPGR-- 349 Query: 411 NPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINAD 470 N ++ +G G +HCLG + A + + ++ + ++ + Sbjct: 350 ----------------KPNRHITFGHGMHHCLGSALARIELSVVLRVLAER--VSRVDLE 391 Query: 471 VEIPEFDLSRYGFGLMQPEHDVPVRYRIR 499 E ++Q ++PVR+ R Sbjct: 392 REPAWLRAI-----VVQGYRELPVRFTGR 415 >5YSW-A nrPDB Length = 441 Score = 67.6 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 49/265 (18%), Positives = 88/265 (33%), Gaps = 56/265 (21%) Query: 235 SRLWKLLSPARLARRAHRSKWLESYLLHLEEM--GVSEEMQARALVLQLWATQGNMGPAA 292 L + +RA+ + + S L+H ++++ L L A Sbjct: 227 DALRAFMQALVTDKRANPAGDIISGLIHHAGADPALTDDELINIANLLLIAGYDTTASML 286 Query: 293 FWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLT 352 + LL+ P LA +R + I D+V E LR Sbjct: 287 GLGIFVLLQRPAQLATLRDDPSRI------------------------ADAV-EELLRYL 321 Query: 353 AA--PFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFL 410 + P I R DL ++ G ++ ++ RD + DP++ Sbjct: 322 SVVNPGIFRFAKEDLEFAGE-----HIPAGST-VVVSVVATNRDARHWPDPDL------- 368 Query: 411 NPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHL-DLELINA 469 D R + ++ +G G + CLG+ A ++ +L L ++ L Sbjct: 369 ------------DLTRPRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVP 416 Query: 470 DVEIP-EFDLSRYGFGLMQPEHDVP 493 E+P D+ YG + D P Sbjct: 417 PEEVPLRNDMLTYGVHSLPIAWDAP 441 >1GWI-A nrPDB Length = 411 Score = 67.2 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 36/234 (15%), Positives = 75/234 (32%), Gaps = 49/234 (20%) Query: 232 SVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMG--VSEEMQARALVLQLWATQGNMG 289 + + L +++ A+RA L S L+ E G +++ L L + A Sbjct: 189 ATLTELASIMTDTVAAKRAAPGDDLTSALIQASENGDHLTDAEIVSTLQLMVAAGHETTI 248 Query: 290 PAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESL 349 ++ L +PE A+ +L + +V+ E+L Sbjct: 249 SLIVNAVVNLSTHPE-QRAL------VLSGEAEWS------------------AVVEETL 283 Query: 350 RLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIY-TDPEVFKYNR 408 R + T V++ A + + GD L++ + + RD + + F R Sbjct: 284 RFSTP---TSHVLIRFAAEDVPVGDRVIPAGDALIVS-YGALGRDERAHGPTADRFDLTR 339 Query: 409 FLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHL 462 N ++ +G G + C G + + + + Sbjct: 340 -----------------TSGNRHISFGHGPHVCPGAALSRMEAGVALPALYARF 376 >4UBS-A nrPDB Length = 393 Score = 66.8 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 43/265 (16%), Positives = 83/265 (31%), Gaps = 51/265 (19%) Query: 213 LLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSK-WLESYLLHLEEMGVSEE 271 +R L + +++L L +R L+ + G + Sbjct: 160 FFESQSRRLLRGPGIAEVQDARAQLDDYLYALIDRKRKEPGDGLLDDLIQEQLNRGTVDR 219 Query: 272 MQARAL-VLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTL 330 + +L L L A LL++PE LA +R E Sbjct: 220 AELVSLATLLLIAGHETTANMISLGTFTLLRHPEQLAELRAE------------------ 261 Query: 331 PQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLS 390 P + + E LR + ++ +A + + R D ++F Sbjct: 262 ----PGLMP---AAVEELLRF----LSIADGLLRVATEDIEVAGTTI-RADEGVVFATSV 309 Query: 391 PQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNS 450 RD + +P+ ++R +++ +G G + CLG++ A Sbjct: 310 INRDAAGFAEPDALDWHR------------------SARHHVAFGFGIHQCLGQNLARAE 351 Query: 451 IKQFVFLVLVHL-DLELINADVEIP 474 ++ + + L L L EIP Sbjct: 352 MEIALGTLFERLPGLRLAAPADEIP 376 >6DCD-A nrPDB Length = 424 Score = 66.4 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 33/216 (15%), Positives = 64/216 (29%), Gaps = 49/216 (22%) Query: 248 RRAHRSKWLESYLLHLEEMGVSEEMQ--ARALVLQLWATQGNMGPAAFWLLLFLLKNPEA 305 RR R+ L + G + E+ R+ A Q + L P+ Sbjct: 215 RRQPRNDVLTALATATYPDGSTPEVIDVVRSATFLFAAGQETTAKLLTAAMRVLGDRPDI 274 Query: 306 LAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDL 365 +R + ++ + + ESLR+ + + L Sbjct: 275 QRRLRE-------------------------NRSLIPNFIEESLRMDSP----VKSDSRL 305 Query: 366 AMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGK 425 A ++ G +++ P + RDP + DP F+ +R Sbjct: 306 ARKRTTVGGLDIAAGTVVMVLPG-AANRDPRRFEDPHEFRLDR----------------- 347 Query: 426 RLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVH 461 +M + G + C G A + + +L Sbjct: 348 PNVREHMAFARGVHSCPGGPLARVEGRVSLERILDR 383 >1UED-A nrPDB Length = 406 Score = 65.7 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 50/387 (12%), Positives = 103/387 (26%), Gaps = 77/387 (19%) Query: 77 LLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQAL 136 +L H + + R + + + + P + R +L E Sbjct: 67 ILGDHEH----FTTRPQFTQSKSGAHVEAQFVGQISTYDPPEHTRLR---KMLTPEFTVR 119 Query: 137 TEAMYTNLHAVLLGDATEAGSGWH-EMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQ 195 L+ D + L + L GI + + Sbjct: 120 RIRRMEPAIQSLIDDRLDLLEAEGPSADLQGLFADPVGAHALCELLGIPRDDQREFVRRI 179 Query: 196 DRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKW 255 R +AD+ + + + + L +RA Sbjct: 180 RR--NADLSRGLK--------------------ARAADSAAFNRYLDNLLARQRADPDDG 217 Query: 256 LESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELES 315 L ++ V++E + + + +L LL NP + + E Sbjct: 218 LLGMIVRDHGDNVTDEELKGLCTALILGGVETVAGMIGFGVLALLDNPGQIELLFESPEK 277 Query: 316 ILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREF 375 + V++E +R + + LA+ Sbjct: 278 -------------------------AERVVNELVRYLSP---VQAPNPRLAIKDVVIDGQ 309 Query: 376 NLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWG 435 ++ GD +L L RD + DP+V NR D + +G Sbjct: 310 LIKAGDYVLCS-ILMANRDEALTPDPDVLDANRAAVSD------------------VGFG 350 Query: 436 AGHNHCLGRSYAVNSIKQFVFLVLVHL 462 G ++C+G + A + ++ + Sbjct: 351 HGIHYCVGAALARSMLRMAYQTLWRRF 377 >5DE9-A nrPDB Length = 410 Score = 65.3 bits (157), Expect = 7e-11, Method: Composition-based stats. Identities = 42/258 (16%), Positives = 80/258 (31%), Gaps = 51/258 (19%) Query: 233 VKSRLWKLLSPARLARRAHRSKWLESYL-LHLEEMGVSEEMQARALVLQLWATQGNMGPA 291 K+ + S R + + S L + ++ VL + + Sbjct: 191 AKNEMNAYFSDLIGLRSDSAGEDVTSLLGAAVGRDEITLSEAVGLAVLLQIGGEAVTNNS 250 Query: 292 AFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL 351 + LL PE +R E + + E LR Sbjct: 251 GQ-MFHLLLSRPELAERLRSE-----PEIRP--------------------RAIDELLRW 284 Query: 352 TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLN 411 P + +A+ + + +R GD + + +L+ RDPE++ DP+ + R Sbjct: 285 --IPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVS-YLAANRDPEVFPDPDRIDFER--- 338 Query: 412 PDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADV 471 N ++ +G G ++C G A + V VL + + V Sbjct: 339 ---------------SPNPHVSFGFGPHYCPGGMLARLESELLVDAVLDR--VPGLKLAV 381 Query: 472 EIPEFDLSRYGFGLMQPE 489 + + G + PE Sbjct: 382 APEDVPFKK-GALIRGPE 398 >5DQN-A nrPDB Length = 426 Score = 64.9 bits (156), Expect = 7e-11, Method: Composition-based stats. Identities = 34/244 (13%), Positives = 79/244 (32%), Gaps = 56/244 (22%) Query: 236 RLWKLLSPARLARRAHRSKWLESYLL--HLEEMGVSEEMQARALVLQLWATQGNMGPAAF 293 L R + ++ + + L+ ++ +S++ +V+ A + Sbjct: 202 ELISYAMKMAEERAVNPTEDIVTKLIEADIDGEKLSDDEFGFFVVMLAVAGNETTRNSIT 261 Query: 294 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-T 352 ++ +NP+ + E E +R T Sbjct: 262 HGMIAFAQNPDQWELYKKERPETAAD---------------------------EIVRWAT 294 Query: 353 AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNP 412 R + D+ + +++G R+++ + S D E++ DP F R Sbjct: 295 PVSAFQRTALEDVEL-----GGVQIKKGQRVVMS-YRSANFDEEVFEDPHTFNILR---- 344 Query: 413 DGSEKKDFYKDGKRLKNYNMPWG-AGHNHCLGRSYAVNSIKQFVFLVLVHL-DLELINAD 470 N ++ +G G ++C+G + A +I + ++ DL+ I A Sbjct: 345 --------------SPNPHVGFGGTGAHYCIGANLARMTINLIFNAIADNMPDLKPIGAP 390 Query: 471 VEIP 474 + Sbjct: 391 ERLK 394 >5Z9I-A nrPDB Length = 398 Score = 64.9 bits (156), Expect = 8e-11, Method: Composition-based stats. Identities = 71/449 (15%), Positives = 131/449 (29%), Gaps = 72/449 (16%) Query: 41 GYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYA 100 G+ GK + ++ ++ + +L +P V RLD Sbjct: 14 GHFWMRGKRPDKIVD--YDEELQLWNVYGYPESAAILSNPK----VFSSDTMRLDP---- 63 Query: 101 IFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWH 160 I L E I + H P K R L+ A + ++ + + G Sbjct: 64 IKLDEAIVEGDFAHTDP--PKHRRLRGLVDHAFTPSLVAKMESRVHGIIHELLDGVEGKS 121 Query: 161 EMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARG 220 + L+ + L L G+ R Q D++ D F P+ Sbjct: 122 QFDLVAEFAAPLPLIMISDLLGVPESDRALFRQWMDKM--LDGSEKFES-----PETVLE 174 Query: 221 SLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLH--LEEMGVSEEMQARALV 278 K+ + R + R + L S L+H ++ +++ + Sbjct: 175 QEEELHKELELLWEMRDY--WHERAAESRKRPREDLISQLVHAEVDGQKLNDSQISNIAN 232 Query: 279 LQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDST 338 L +L L ++ Q + + + +P Sbjct: 233 RLLVNGHLTTAMLIANTMLCL--------------DAFSDQDARVRADRSLVP------- 271 Query: 339 PVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIY 398 ++L ES+R + V + + + LL++ + RD + Sbjct: 272 ----ALLEESMRYMSP----ICGVGRATNSEVEVAGTVIPKDQLLLVWTG-AANRDERQF 322 Query: 399 TDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLV 458 P+VF R N ++ +G G + CLGR A K V ++ Sbjct: 323 EKPDVFDAGR------------------SPNAHLGFGRGIHFCLGRQLARMESKAAVEIL 364 Query: 459 LVHLDLELINADVEIPEFDLSRYGFGLMQ 487 L L L P F G+ Sbjct: 365 LDRLP-TLRADPANPPTFLQVVDASGVAT 392 >5HDI-A nrPDB Length = 404 Score = 64.9 bits (156), Expect = 8e-11, Method: Composition-based stats. Identities = 34/213 (15%), Positives = 62/213 (29%), Gaps = 48/213 (22%) Query: 250 AHRSKWLESYLLHLEEMGVSEEMQARALVLQLWA-TQGNMGPAAFWLLLFLLKNPEALAA 308 A L L G + + A+ +++ L+A + + L P+ Sbjct: 210 ADPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQ 269 Query: 309 VRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMP 368 VR + +L + + E+LR PF Sbjct: 270 VRA-------------------------NPELLGAFIEETLRYEP-PFRGHY---RHVRN 300 Query: 369 MADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLK 428 L LLL + RDP + P F+ +R Sbjct: 301 ATTLDGTELPADSHLLLLWG-AANRDPAQFEAPGEFRLDR-----------------AGG 342 Query: 429 NYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVH 461 ++ +G G + C+G + A + + L+L Sbjct: 343 KGHISFGKGAHFCVGAALARLEARIVLRLLLDR 375 >4C9K-A nrPDB Length = 421 Score = 64.5 bits (155), Expect = 9e-11, Method: Composition-based stats. Identities = 64/482 (13%), Positives = 138/482 (28%), Gaps = 113/482 (23%) Query: 22 RRTRRPGEPPLDLGSIPWLG-YALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDP 80 +R ++P PPL P+ G + + + R E+ Sbjct: 45 KRVQQPDTPPLV--WTPFTGGHWIATRGTLIDEIYRSPERFS------------------ 84 Query: 81 HSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAM 140 V+W PR A + M + P ++P + + L Sbjct: 85 ---SRVIWVPR-----EAGEAYDMVPT-KLDPPEHTPYR-------KAIDKGLNLAEIRK 128 Query: 141 YTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHS 200 + + + E + + +L L G+ T + + Sbjct: 129 LEDQIRTIAVEIIEGFADRGHCEFGSEFSTVFPVRVFLALAGLPVEDATKLGLLANEMTR 188 Query: 201 ADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYL 260 G+ + + ++ ++P ARR L + + Sbjct: 189 -----------------PSGNTPEEQGRSLEAANKGFFEYVAPIIAARRGGSGTDLITRI 231 Query: 261 LHL--EEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILW 318 L++ + + ++ + L L + +++++L ++PE +A +R E Sbjct: 232 LNVEIDGKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSRHPETVAEMRRE------ 285 Query: 319 QAEQPVSQTTTLPQKVLDSTPV-LDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNL 377 P+ L + E R A R VV D+ L Sbjct: 286 --------------------PLKLQRGVEELFRRFAVVSDARYVVSDMEFH-----GTML 320 Query: 378 RRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAG 437 + GD +LL P D + DP +R + + G Sbjct: 321 KEGDLILL-PTALHGLDDRHHDDPMTVDLSR------------------RDVTHSTFAQG 361 Query: 438 HNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYR 497 + C G A + + + + + + + Y G++ ++P+ + Sbjct: 362 PHRCAGMHLARLEVTVML------QEWLARIPEFRLKDRAVPIYHSGIVAAVENIPLEWE 415 Query: 498 IR 499 + Sbjct: 416 PQ 417 >4MM0-A nrPDB Length = 399 Score = 64.5 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 38/234 (16%), Positives = 71/234 (30%), Gaps = 49/234 (20%) Query: 231 CSVKSRLWKLLSPARLARRAHRSKWLESYLLHL--EEMGVSEEMQARALVLQLWATQGNM 288 + + L L A+R + L S L+ E+ +++ ++ L A Sbjct: 182 TAARDALESYLDGLVAAKRENPGSDLLSALVATAAEDNELTDHDVRSLSLILLLAGYEPA 241 Query: 289 GPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSES 348 +L LL+ P+ LA EL +L S + E Sbjct: 242 SNQLGSSVLTLLRFPDRLA----ELRRDPG---------------------LLPSAVEEL 276 Query: 349 LRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNR 408 +R A + + + + ++ +L T + R Sbjct: 277 MRYAPAG---DGALFRVTLEDVTIGDTHIPANSAVLAS------------TQAANWDPRR 321 Query: 409 FLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHL 462 F +P G R N + G G + CLG + A ++ + +L Sbjct: 322 FDDPTG-------LRLDRPDNQHTALGHGIHFCLGAALARVELQVAIGALLRRF 368 >5HIW-A nrPDB Length = 398 Score = 64.1 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 46/276 (16%), Positives = 79/276 (28%), Gaps = 54/276 (19%) Query: 217 LARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLH--LEEMGVSEEMQA 274 + + + V + + L AH S L + + E E Sbjct: 163 MPQDPVVVAEGRSAHAAME---AQLREIAEREVAHPSDTLLGEIARAIVAEGLGGVEACE 219 Query: 275 RALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKV 334 ++ + + LL+ LL +P+A+ +R Sbjct: 220 GVVLTLILGSYETTSWMLANLLVALLAHPDAMNQLRQ----------------------- 256 Query: 335 LDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRD 394 +L + ES R + + +V A L G L L ++ D Sbjct: 257 --QPSLLPQAIEESTRWCS----SAAGIVRFVEREATIGGETLAAGTILYLS-LIARHYD 309 Query: 395 PEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQF 454 EIY PE F +R + +G G ++C+G A + Sbjct: 310 EEIYPRPETFDIHR------------------RPVGMLNFGGGLHYCVGAPLARMEARVG 351 Query: 455 VFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEH 490 V L+L L P F + G P+ Sbjct: 352 VSLLLERFP-ALRADPTVQPTFSTAPRGAAAFGPDQ 386 >5XW2-A nrPDB Length = 419 Score = 64.1 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 64/446 (14%), Positives = 121/446 (27%), Gaps = 72/446 (16%) Query: 42 YALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAI 101 + +G+ + ++ + + + + VL DP +RL Sbjct: 34 HFWLYGRRPRQMVE--FDEKMNAWNVYGYAEAIEVLGDP----GTFSSHMSRLLPMGADE 87 Query: 102 FLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHE 161 E L P + R L+ T + L + E + Sbjct: 88 AFTE---GDLLQTDPPDHRELR---KLVSHAF---TPKVVAELEPRITALTQELLDAVAD 138 Query: 162 MGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGS 221 D + + E L + ++ H+ + Sbjct: 139 RDTFDLMTALAYPLPVTVV--AELLSIPSADRHLFEGWMTEIVHSLGDVSMEDAP---ED 193 Query: 222 LSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLH-LEEMGVSEEMQARALVLQ 280 + M ++ L L A RR R + + ++ +++ + Sbjct: 194 QERIFEAGMAPMRKMLEYLREHAAECRRRPRGDLMGKLIEAEVDGRRLTDNHIVNFAKML 253 Query: 281 LWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPV 340 L A +L L PE A VR + I Sbjct: 254 LIAGYLTTTMLIGNTVLCLDSYPEQAARVRADRSLIPG---------------------- 291 Query: 341 LDSVLSESLR-LTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYT 399 +L ES+R L+ R D+ + D++++ F + RD + Sbjct: 292 ---LLEESMRFLSPVAATYRATTRDVEVAGQRLS------ADQMVMVWFGAANRDARQFA 342 Query: 400 DPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVL 459 +PE+F R N ++ +G G + CLG A + + +L Sbjct: 343 EPELFDMTR------------------GPNPHLGFGRGIHFCLGGPLARMEGRVALDHLL 384 Query: 460 VHLDLELINADVEIPEFDLSRYGFGL 485 EL P F G+ Sbjct: 385 DRFP-ELYTDPERPPTFMPGFDTTGV 409 >3NV6-A nrPDB Length = 452 Score = 64.1 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 55/422 (13%), Positives = 114/422 (27%), Gaps = 88/422 (20%) Query: 76 VLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQA 135 V DP L A + M + P ++P L + L Sbjct: 110 VYSDP----TRFSSEVIFLPKEAGEKYQMVPT-KMDPPEHTPYR-------KALDKGLNL 157 Query: 136 LTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQ 195 + + ++ + E A Y L+ + + + Sbjct: 158 AKIRKVEDKVREVASSLIDSFAARGECD---------FAAEYAELFPVHVFMALADLPLE 208 Query: 196 DRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKW 255 D ++ + G+ + + + + + P AR Sbjct: 209 DIPVLSEYARQMTR--------PEGNTPEEMATDLEAGNNGFYAYVDPIIRARVGGDGDD 260 Query: 256 LESYLLHLE--EMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGEL 313 L + +++ E ++ + + L L + + ++ L ++PE +A +R Sbjct: 261 LITLMVNSEINGERIAHDKAQGLISLLLLGGLDTVVNFLSFFMIHLARHPELVAELR--- 317 Query: 314 ESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGR 373 L + E R R V D + + Sbjct: 318 ------------------SDPLKLMRGAE----EMFRRFPVVSEARMVAKD-----QEYK 350 Query: 374 EFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMP 433 L+RGD +LL P D +P ++R + Sbjct: 351 GVFLKRGDMILL-PTALHGLDDAANPEPWKLDFSR------------------RSISHST 391 Query: 434 WGAGHNHCLGRSYAVNSIKQFVFLVLVHL-DLELINADVEIPEFDLSRYGFGLMQPEHDV 492 +G G + C G A + + L + + + I Y G++ +V Sbjct: 392 FGGGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGETPI-------YHSGIVAAVENV 444 Query: 493 PV 494 P+ Sbjct: 445 PL 446 >3AWQ-A nrPDB Length = 415 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 62/455 (13%), Positives = 120/455 (26%), Gaps = 93/455 (20%) Query: 43 ALDFGKDAASFLTR-MKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAI 101 L D F++R + + F + L + + R + A + Sbjct: 13 TLSLLADPYRFISRQCQRLGANAFESRFLLKKTNCLKGAKAAEIFYDTTRFERE-GAMPV 71 Query: 102 FLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHE 161 + + +F + K + +T L + + A GW Sbjct: 72 AIQKTLFGQGGVQGLDGETHRHRKQMFMG----LMTPERVRALAQLFEAEWRRAVPGWTR 127 Query: 162 MGLLDFSYSF--LLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLAR 219 G + F L G+ ++A + D + L +LAR Sbjct: 128 KGEIVFYDELHEPLTRAVCAWAGVPLPDDEAGNRAGELRALFDAAGSASP-RHLWSRLAR 186 Query: 220 GSLSVGDKDHMCSVKSRLWKL----LSPARLARRAHRSKWLESYLLHLEEMGV--SEEMQ 273 + K + +++ + A R L ++ +E + V Sbjct: 187 RRVDAWAKRIIEGIRAGSIGSGSGTAAYAIAWHRDRHDDLLSPHVAAVELVNVLRPTVAI 246 Query: 274 ARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQK 333 A + A Q G A L++ P+ Sbjct: 247 AVYITFVAHALQTCSGIRAA-----LVQQPD----------------------------- 272 Query: 334 VLDSTPVLDSVLSESLRLTAA-PFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQ 392 + + E R P + D + G +++L Sbjct: 273 ------YAELFVQEVRRFYPFFPAVVARASQDF-----EWEGMAFPEGRQVVLD-LYGSN 320 Query: 393 RDPEIYTDPEVFKYNRF--LNPDGSEKKDFYKDGKRLKNYNMPWGAGH----NHCLGR-- 444 D + DP+ F+ RF + D +P G G + C G Sbjct: 321 HDAATWADPQEFRPERFRAWDED--------------SFNFIPQGGGDHYLGHRCPGEWI 366 Query: 445 SYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLS 479 A+ + + + + D +P+ DLS Sbjct: 367 VLAIMKVAAHLLVNAMRYD---------VPDQDLS 392 >4XE3-A nrPDB Length = 407 Score = 63.0 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 32/218 (14%), Positives = 70/218 (32%), Gaps = 47/218 (21%) Query: 246 LARRAHRSKWLESYLLHLE-EMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPE 304 R A L + L + + +++ V L A L+ LL + Sbjct: 206 QRRDAPTEDLLGALALATDNDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLTERK 265 Query: 305 ALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVD 364 ++ + + + + E LR T P ++ V Sbjct: 266 RYESLVADPALVP-------------------------AAVEEMLRYT--PLVSAGSFVR 298 Query: 365 LAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDG 424 +A + +R G+ ++ F S RD E++ + ++R NP Sbjct: 299 VATEDVELSTVTVRAGEPCVV-HFASANRDEEVFDHADELDFHRERNP------------ 345 Query: 425 KRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHL 462 ++ +G G +HC+G +++ + ++ Sbjct: 346 ------HIAFGHGAHHCIGAQLGRLELQEALSALVRRF 377 >2NZA-A nrPDB Length = 413 Score = 62.6 bits (150), Expect = 4e-10, Method: Composition-based stats. Identities = 42/234 (17%), Positives = 77/234 (32%), Gaps = 46/234 (19%) Query: 228 DHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGN 287 + K L+ ++ AR + S L G E +A L L Sbjct: 189 EAAERAKRGLYGWITETVRARAGSEGGDVYSMLGAAVGRGEVGETEAVGLAGPLQIGGEA 248 Query: 288 MGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSE 347 + +L LL E +A +R +P ++ T L E Sbjct: 249 VTHNVGQMLYLLLTRRELMARMRE----------RPGARGTALD---------------E 283 Query: 348 SLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYN 407 LR + T + +A+ + + G+ + + +L+ RDP+++ DP+ + Sbjct: 284 LLRWISHR--TSVGLARIALEDVEVHGTRIAAGEPVYVS-YLAANRDPDVFPDPDRIDLD 340 Query: 408 RFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVH 461 R N ++ +G GH+ C G A + V +L Sbjct: 341 R------------------DPNPHLAYGNGHHFCTGAVLARMQTELLVDTLLER 376 >5M0P-A nrPDB Length = 428 Score = 62.6 bits (150), Expect = 4e-10, Method: Composition-based stats. Identities = 63/393 (16%), Positives = 102/393 (25%), Gaps = 76/393 (19%) Query: 66 TILVGGRYVTVLLDPHSYDAVVWE---PRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKA 122 T +GG+ V+ + R + L H +K Sbjct: 44 TKALGGKPFVVVTGKEGAEMFYNNDVVQREGMLPKRIVNTLA----GKGAIHTVD-GKKH 98 Query: 123 RMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYG 182 + L + L L T+ E+ + S L + G G Sbjct: 99 VDRKALFMSLMTEGNLNYVRELTRTLWHANTQRMESMDEVNIYRESIVLLTKVGTRWA-G 157 Query: 183 IEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLS 242 ++A P E A D D +FR L + R+ L Sbjct: 158 VQAPPEDIERIATDMDIMID---SFRALGGAFKGYKASK----------EARRRVEDWLE 204 Query: 243 PARLARRA---HRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPA---AFWLL 296 + R H + Y E + M +R + L T + + L Sbjct: 205 EQIIETRKGNIHPPEGTALYEFAHWEDYLGNPMDSRTCAIDLMNTFRPLIAINRFVSFGL 264 Query: 297 LFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTA-AP 355 + +NP ++ E + E R P Sbjct: 265 HAMNENPITREKIKSEPD-------------------------YAYKFAQEVRRYYPFVP 299 Query: 356 FITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGS 415 F+ + VD+ + + G L L D ++ DP F+ RF DGS Sbjct: 300 FLPGKAKVDIDF-----QGVTIPAGVGLALD-VYGTTHDESLWDDPNEFRPERFETWDGS 353 Query: 416 EKKDFYKDGKRLKNYNMPWGAGH----NHCLGR 444 +P G G + C G Sbjct: 354 ------------PFDLIPQGGGDYWTNHRCAGE 374 >3IVY-A nrPDB Length = 433 Score = 62.6 bits (150), Expect = 4e-10, Method: Composition-based stats. Identities = 32/243 (13%), Positives = 80/243 (32%), Gaps = 54/243 (22%) Query: 232 SVKSRLWKLLSPARLARRAHRSKWLESYLLH--LEEMGVSEEMQARALVLQLWATQGNMG 289 + + L + + + + + L+ ++ +S++ +V+ A Sbjct: 215 ASSAELIGYAMKMAEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTR 274 Query: 290 PAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESL 349 + ++ ++P+ + ++ + E + Sbjct: 275 NSITQGMMAFAEHPD-QWELYKKV-------RPETAAD-------------------EIV 307 Query: 350 RLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRF 409 R A+ + +++G R+++F + S D E++ DP F R Sbjct: 308 RWATP----VTAFQRTALRDYELSGVQIKKGQRVVMF-YRSANFDEEVFQDPFTFNILR- 361 Query: 410 LNPDGSEKKDFYKDGKRLKNYNMPWG-AGHNHCLGRSYAVNSIKQFVFLVLVHL-DLELI 467 N ++ +G G ++C+G + A +I V H+ DL+ I Sbjct: 362 -----------------NPNPHVGFGGTGAHYCIGANLARMTINLIFNAVADHMPDLKPI 404 Query: 468 NAD 470 +A Sbjct: 405 SAP 407 >5FYF-A nrPDB Length = 470 Score = 62.2 bits (149), Expect = 5e-10, Method: Composition-based stats. Identities = 38/241 (15%), Positives = 76/241 (31%), Gaps = 51/241 (21%) Query: 226 DKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGV---SEEMQARALVLQLW 282 D M SRLW+ R A + + E + E L L + Sbjct: 248 DAADMARSFSRLWRDKEARRAAGEEPGFDLISLLQSNKETKDLINRPMEFI-GNLTLLIV 306 Query: 283 ATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLD 342 + L+ + + P ++ + E I Sbjct: 307 GGNDTTRNSMSGGLVAMNEFPREFEKLKAKPELIP------------------------- 341 Query: 343 SVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPE 402 +++SE +R R +A + +++GDR++++ + S RD + +P+ Sbjct: 342 NMVSEIIRWQTPLAYMR----RIAKQDVELGGQTIKKGDRVVMW-YASGNRDERKFDNPD 396 Query: 403 VFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHL 462 F +R + +M +G G + C+G A ++ +L Sbjct: 397 QFIIDR-----------------KDARNHMSFGYGVHRCMGNRLAELQLRILWEEILKRF 439 Query: 463 D 463 D Sbjct: 440 D 440 >2WM5-A nrPDB Length = 435 Score = 61.8 bits (148), Expect = 6e-10, Method: Composition-based stats. Identities = 61/432 (14%), Positives = 120/432 (27%), Gaps = 85/432 (19%) Query: 60 KHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSD 119 K+ D+F P + + F + P Sbjct: 81 KYDDVF---------YASRHPDIFSSYPNITINDQTPELAEY------FGSMIVLDDPRH 125 Query: 120 EKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLT 179 ++ R +++ R A + + D Sbjct: 126 QRLR---SIVSRAFTPKVVARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQI 182 Query: 180 LYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWK 239 + + +P+ + H +V F P LA D D V + + Sbjct: 183 ICDMMGIPKADHQRI---FHWTNVILGFG-----DPDLA------TDFDEFMQVSADIGA 228 Query: 240 LLSPARLARRAHRSKWLESYLLH--LEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLL 297 + RR + L S L+ ++ +S A +L + A A +L Sbjct: 229 YATALAEDRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVL 288 Query: 298 FLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-TAAPF 356 L + PE + + + A + E +R + + Sbjct: 289 ALSRYPEQRDRWWSDFDGLAPTA------------------------VEEIVRWASPVVY 324 Query: 357 ITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSE 416 + R + D+ + R + GD++ L+ + S RD + DP F R Sbjct: 325 MRRTLTQDIEL-----RGTKMAAGDKVSLW-YCSANRDESKFADPWTFDLAR-------- 370 Query: 417 KKDFYKDGKRLKNYNMPWGAG-HNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPE 475 N ++ +G G + CLG + A I+ F L +++ + Sbjct: 371 ----------NPNPHLGFGGGGAHFCLGANLARREIR-VAFDELRRQMPDVVATEEPARL 419 Query: 476 FDLSRYGFGLMQ 487 +G + Sbjct: 420 LSQFIHGIKTLP 431 >5NWS-A nrPDB Length = 435 Score = 61.4 bits (147), Expect = 9e-10, Method: Composition-based stats. Identities = 60/383 (15%), Positives = 107/383 (27%), Gaps = 72/383 (18%) Query: 102 FLMERIFDVQLPHYSPSDEKAR--MKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGW 159 L + L P + R + R + L + + LL + Sbjct: 106 PLRVYLLGSILDSDPPDHPRLRRLVTRAFAARRILGLRPGI-ERIADRLLAELPRREEED 164 Query: 160 HEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLAR 219 + LL+ L L GI A + + Sbjct: 165 GTVDLLEHFAYPLSITVICELVGIPATDLERWREWGGDLV-------------------- 204 Query: 220 GSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMG--VSEEMQARAL 277 S+ H V L R A A L + ++ G +S+ + Sbjct: 205 -SMRPERLRHSFPVMIDYCHRLIEQRRA--ALTDDLLSELIRAQDDDGGRLSDIETVTMI 261 Query: 278 VLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDS 337 + + A LL +P A +R + Sbjct: 262 LTLVLAGHETSAHLIGNGTAALLTHPGQWALLRKDPA----------------------- 298 Query: 338 TPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEI 397 +L + E +R + + R + A + + RGD + L +S DP Sbjct: 299 --LLPRAVHELMRWCGSVHVAR---LRYATEDLELAGTPVARGDAVQLV-LVSANFDPRH 352 Query: 398 YTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFL 457 Y+DP+ R + ++ +G G ++CLG + A + + Sbjct: 353 YSDPDRLDITR--------------HQEGQAENHVGFGHGIHYCLGATLARQEGEVALAR 398 Query: 458 VLVHL-DLELINADVEIPEFDLS 479 +L DL L + D E+ L Sbjct: 399 LLETYPDLALADGDPEVRRARLP 421 >3BUJ-A nrPDB Length = 397 Score = 61.4 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 35/199 (17%), Positives = 61/199 (30%), Gaps = 50/199 (25%) Query: 253 SKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGE 312 L L + +S +V ++ + +L LL +P+ L +R Sbjct: 203 EDLLALMLDAHDRGLMSRNEIVSTVVTFIFTGHETVASQVGNAVLSLLAHPDQLDLLRRR 262 Query: 313 LESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-TAAPFITREVVVDLAMPMAD 371 + +L + E LR + TR++ VD+ + Sbjct: 263 PD-------------------------LLAQAVEECLRYDPSVQSNTRQLDVDVELRGRR 297 Query: 372 GREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYN 431 R D +++ + RDP Y P+ F R + Sbjct: 298 LRR------DDVVVVLAGAANRDPRRYDRPDDFDIER------------------DPVPS 333 Query: 432 MPWGAGHNHCLGRSYAVNS 450 M +GAG +CLG A Sbjct: 334 MSFGAGMRYCLGSYLARTQ 352 >6GII-A nrPDB Length = 479 Score = 61.0 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 53/425 (12%), Positives = 117/425 (27%), Gaps = 68/425 (16%) Query: 45 DFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHS--YDAVVWEPRTRLDFHAYAIF 102 + D A F+ +E+ + + VT D V + P L A Sbjct: 75 AYMADPAQFVRWAREQVPIFYAPKLNYWVVTRYDTIKQIFRDPVTFSPSNVLQSFAQPSA 134 Query: 103 LMERIFDVQ--LPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWH 160 + ++ + + + +E M L ++ ++ A + + Sbjct: 135 EVRQVLERYGYAFNRTLVNEDEPMHLERRRVLMEPFASEHLAEHEPMVRELVRRAVNRFI 194 Query: 161 EMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARG 220 + G D + + + + ++++ + HT R P Sbjct: 195 DTGRADLVDQMIWEVP----FTVALHFLGVDDDDREKMRRFAIAHTVNAFGRPSP----- 245 Query: 221 SLSVGDKDHMCSVKSRLWKLLSP--ARLARRAHRSKWLESYLLH--LEEMGVSEEMQARA 276 ++ + + W+ ++ R A W+ + L V++ Sbjct: 246 ----EEQLAVAETVGQFWQFCGEVLEKMRRTADGPGWMRYSIRQQKLYPDVVTDSYLHSM 301 Query: 277 LVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLD 336 + + A A L LL++ + + + +P Sbjct: 302 MQAIIVAAHETTVFATTNALKTLLEHETVWREI--------------CADPSLIP----- 342 Query: 337 STPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPE 396 + E LR R + L G +L+ S D Sbjct: 343 ------AAAEECLRYNGPVAGWRRRTTR----EVEVEGVRLPVGANILMV-VASANHDSA 391 Query: 397 IYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVF 456 + DPE F R + ++ +G G + CLGR+ ++ + Sbjct: 392 HFDDPEFFDIGR-----------------SNASEHLNFGYGAHQCLGRNLGRMEMQIMIE 434 Query: 457 LVLVH 461 + Sbjct: 435 ELSRR 439 >1F4U-A nrPDB Length = 368 Score = 60.3 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 30/219 (13%), Positives = 69/219 (31%), Gaps = 53/219 (24%) Query: 260 LLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQ 319 + + +S+ + ++L L A ++ + +R E Sbjct: 186 VSRVVNSNLSDIEKLGYIILLLIAGNETTTNLISNSVIDFTRF-NLWQRIREE------- 237 Query: 320 AEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFIT-REVVVDLAMPMADGREFNLR 378 + L + + E+LR + T R+ + + + Sbjct: 238 -----------------NL-YLKA-IEEALRYSPPVMRTVRKTKERVKLGDQ-----TIE 273 Query: 379 RGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGH 438 G+ + ++ S RD E++ D E F +R N ++ +G+G Sbjct: 274 EGEYVRVW-IASANRDEEVFHDGEKFIPDR------------------NPNPHLSFGSGI 314 Query: 439 NHCLGRSYAVNSIKQFVFLVLVHL-DLELINADVEIPEF 476 + CLG A + + +E+++ + E Sbjct: 315 HLCLGAPLARLEARIAIEEFSKRFRHIEILDTEKVPNEV 353 >2QBO-A nrPDB Length = 421 Score = 60.3 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 40/241 (16%), Positives = 67/241 (27%), Gaps = 52/241 (21%) Query: 232 SVKSRLWKLLSPARLARRAHRSKWLESYLL--HLEEMGVSEEMQARALVLQLWATQGNMG 289 K L+ L P RR S + + ++ + R L L + Sbjct: 196 EAKEALYDYLIPIIEQRRQKPGTDAISIVANGQVNGRPITSDEAKRMCGLLLVVGLDTVV 255 Query: 290 PAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESL 349 + + FL K+PE + E I + E L Sbjct: 256 NFLSFSMEFLAKSPEHRQELIERPERIP-------------------------AACEELL 290 Query: 350 RLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRF 409 R + R + D L++GD++LL LS Sbjct: 291 RRFSLVADGRILTSDYEFH-----GVQLKKGDQILLPQMLSGL----------------- 328 Query: 410 LNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVF-LVLVHLDLELIN 468 + + D R K + +G G + CLG+ A I + + D + Sbjct: 329 --DERENACPMHVDFSRQKVSHTTFGHGSHLCLGQHLARREIIVTLKEWLTRIPDFSIAP 386 Query: 469 A 469 Sbjct: 387 G 387 >2X9P-A nrPDB Length = 404 Score = 60.3 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 45/270 (16%), Positives = 86/270 (31%), Gaps = 57/270 (21%) Query: 214 LPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQ 273 L L G + D++ + L+ ++ +RA + S L + ++E+ Sbjct: 175 LTTLLAGIAKLDDREGAVRAQDDLFGYVAGLVEHKRAEPGPDIISRL---NDGELTEDRV 231 Query: 274 ARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQK 333 A + L+A ++ ++ L +P+ AA + + Sbjct: 232 AHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAAALADPD------------------- 272 Query: 334 VLDSTPVLDSVLSESLRLTAAP---FITREVVVDLAMPMADGREFNLRRGDRLLLFPFLS 390 V+ + E LR A R D+ +R GD +L L Sbjct: 273 ------VMARAVEEVLRTARAGGSVLPPRYASEDMEF-----GGVTIRAGDLVLFDLGL- 320 Query: 391 PQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNS 450 P D +T PE F R N ++ +G G HC+G A Sbjct: 321 PNFDERAFTGPEEFDAAR------------------TPNPHLTFGHGIWHCIGAPLARLE 362 Query: 451 IKQFVFLVLVHLDLELINADVEIPEFDLSR 480 ++ + L + ++ + + L Sbjct: 363 LRTMFTKLFTR--LPELRPELPVEQLRLKE 390 >4PWV-A nrPDB Length = 446 Score = 59.9 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 55/329 (16%), Positives = 98/329 (29%), Gaps = 73/329 (22%) Query: 179 TLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCS----VK 234 + + + + D + F L KL + +LS D D + + Sbjct: 166 CDFAADVAEQIPLNTISDLLGVPAADREF------LLKLNKSALSSEDADQSATDAWLAR 219 Query: 235 SRLWKLLSPARLARRAHRSKWLESYLL--HLEEMGVSEEMQARALVLQLWATQGNMGPAA 292 + + S RRA ++ + S L ++ ++EE+ + + Sbjct: 220 NEILLYFSELVAERRAKPTEDVISVLANSMVDGKPLTEEVIVLNCYSLILGGDETSRLSM 279 Query: 293 FWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL- 351 ++S+ + P KV L+S E LR Sbjct: 280 --------------------IDSVQTFTQYPDQWELLRDGKVT-----LESATEEVLRWA 314 Query: 352 TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLN 411 T A R V D+ + + GD + L+ S RD E++ DP F NR Sbjct: 315 TPAMHFGRRAVTDMELHGQ-----VIAAGDVVTLWNN-SANRDEEVFADPYAFDLNR--- 365 Query: 412 PDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLD--LELINA 469 N ++ +G G + CLG + + L E+ Sbjct: 366 ---------------SPNKHITFGYGPHFCLGAYLGRAEVHALLD-ALRTYTTGFEITGE 409 Query: 470 DVEIPEFDLSRYGFGLMQPEHDVPVRYRI 498 R + +PVR + Sbjct: 410 P--------QRIHSNFLTGLSRLPVRIQP 430 >3OO3-A nrPDB Length = 384 Score = 58.3 bits (139), Expect = 8e-09, Method: Composition-based stats. Identities = 45/287 (15%), Positives = 81/287 (28%), Gaps = 62/287 (21%) Query: 214 LPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQ 273 L ++ R S + +R + ++ +S+E Sbjct: 157 LSRMIRESRESRLPRQRTLSGLGIVNYTKRLTSGKRRDPGDGMIGVIVREHGAEISDEEL 216 Query: 274 ARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQK 333 A L M +L L+ +P+ +A +R Sbjct: 217 AGLAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLRE---------------------- 254 Query: 334 VLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQR 393 ++DS E LR + I +A+ ++ GD L L+ R Sbjct: 255 ---KPELIDSATEEVLRHAS---IVEAPAPRVALADVRMAGRDIHAGDVLTCS-MLATNR 307 Query: 394 DPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQ 453 P + F R K +M +G G +HC+G A ++ Sbjct: 308 APG-----DRFDITR------------------EKATHMAFGHGIHHCIGAPLARLQLRV 344 Query: 454 FVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP 500 + V+ + + +PE DL +P P P Sbjct: 345 ALPAVVGRFP----SLRLAVPEEDLR------FKPGRPAPFAVEELP 381 >6HQD-A nrPDB Length = 420 Score = 57.9 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 32/145 (22%), Positives = 60/145 (41%), Gaps = 25/145 (17%) Query: 332 QKVLDSTPVLDSVLSESLRL-TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLS 390 KV ++ +L SV+ E +R T + R + D+ R +R+GD+++++ +LS Sbjct: 283 DKVRNNRALLASVIPEVVRWQTPIAHMRRTALEDVEF-----RGKQIRKGDKVVMW-YLS 336 Query: 391 PQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNS 450 RD E+ P F +R +++ +G G + CLG A Sbjct: 337 GNRDDEVIDRPMDFIADR-----------------PRARHHLSFGFGIHRCLGNRLAELQ 379 Query: 451 IKQFVFLVLVHLD-LELINADVEIP 474 +K + +E+ V +P Sbjct: 380 LKILWEEMCERYSRIEVCGEPVRVP 404 >2WIY-A nrPDB Length = 394 Score = 57.9 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 39/258 (15%), Positives = 78/258 (30%), Gaps = 47/258 (18%) Query: 224 VGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWA 283 GD D L ++ +R + L LL G E +A A +L +A Sbjct: 173 DGDVDRAAVAFGYLSARVAEMLEDKRVNPGDGLADSLLDAARAGEITESEAIATILVFYA 232 Query: 284 TQGNMGPAAFWLLLFL-LKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLD 342 + L + PE A R + + Sbjct: 233 VGHMAIGYLIASGIELFARRPEVFTAFR--------------NDESARA----------- 267 Query: 343 SVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPE 402 ++++E +R+ + + + G + F + RDPE++ DP+ Sbjct: 268 AIINEMVRMDPPQLSF----LRFPTEDVEIGGVLIEAGSPIR-FMIGAANRDPEVFDDPD 322 Query: 403 VFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHL 462 VF + R + N+ +G G + C G+ + ++ Sbjct: 323 VFDHTR----------------PPAASRNLSFGLGPHSCAGQIISRAEATTVFAVLAERY 366 Query: 463 DLELINADVEIPEFDLSR 480 + + + + D +R Sbjct: 367 ERIELAEEPTVAHNDFAR 384 >1UE8-A nrPDB Length = 367 Score = 57.9 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 21/111 (18%), Positives = 43/111 (38%), Gaps = 23/111 (20%) Query: 345 LSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVF 404 + E+LR + T + + R+ + G+ + ++ S RD E++ DP+ F Sbjct: 244 VEEALRFSPPVMRT----IRVTKEKVKIRDQVIDEGELVRVW-IASANRDEEVFKDPDSF 298 Query: 405 KYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFV 455 +R N ++ +G+G + CLG A + + Sbjct: 299 IPDR------------------TPNPHLSFGSGIHLCLGAPLARLEARIAL 331 >4Z5Q-A nrPDB Length = 423 Score = 57.9 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 34/226 (15%), Positives = 66/226 (29%), Gaps = 48/226 (21%) Query: 232 SVKSRLWKLLSPARLARRAHRSKWLESYLLHLEE--MGVSEEMQARALVLQLWATQGNMG 289 L K RRA L S L+ + ++E + L Sbjct: 210 QSFMDLQKYFEDLVKERRAEPRDDLTSALIEARDAHDRLAEPELIGLCISILIGGFETTA 269 Query: 290 PAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESL 349 + L + E + + E+I + + E L Sbjct: 270 SEISSFVHVLQQRRELWTRLCADPEAIP-------------------------AAVEELL 304 Query: 350 RLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRF 409 R PF + A+ +R G+ +++ + RD ++ + + +R Sbjct: 305 RF--VPFAANGISPRYALEDMTVGGVLVREGEPVIVDTS-AVNRDGLVFDNADEVVIDR- 360 Query: 410 LNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFV 455 N +M +G G +HCLG A +++ + Sbjct: 361 -----------------ADNRHMVFGHGAHHCLGAHLARVELQEAL 389 >3A1L-A nrPDB Length = 425 Score = 57.6 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 40/261 (15%), Positives = 82/261 (31%), Gaps = 54/261 (20%) Query: 204 FHTFRQLDRLLPKLARGSLSVGDKDHM--CSVKSRLWKLLSPARLARRAHRSKWLESYLL 261 HT+ + + + + A + + + + + + R L + L+ Sbjct: 171 DHTWLRANAVALQEASTTRARDGRGYARAEAASQEFTRYFRREVDRRGGDDRDDLLTLLV 230 Query: 262 HLEEMG--VSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQ 319 + G +S + V L A +L L + + L +R ES Sbjct: 231 RARDTGSPLSVDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELRTTPESTP-- 288 Query: 320 AEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-TAAPFITREVVVDLAMPMADGREFNLR 378 + + E +R +TR D+ + + ++ Sbjct: 289 -----------------------AAVEELMRYDPPVQAVTRWAYEDIRL-----GDHDIP 320 Query: 379 RGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGH 438 RG R++ S RDP + DP+V +R + +G G Sbjct: 321 RGSRVVALLG-SANRDPARFPDPDVLDVHR------------------AAERQVGFGLGI 361 Query: 439 NHCLGRSYAVNSIKQFVFLVL 459 ++CLG + A + + +L Sbjct: 362 HYCLGATLARAEAEIGLRALL 382 >2RFC-A nrPDB Length = 343 Score = 57.2 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 29/197 (14%), Positives = 64/197 (32%), Gaps = 51/197 (25%) Query: 267 GVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQ 326 ++ + + + ++L + L+ N + V E I+ A + S Sbjct: 172 KLTMDEKIKYIMLLIIGGNETTT--------NLIGN---MIRVIDENPDIIDDALKNRSG 220 Query: 327 TTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLF 386 + E+LR + A + +++GD+++++ Sbjct: 221 -----------------FVEETLRYYSPIQFLPH---RFAAEDSYINNKKIKKGDQVIVY 260 Query: 387 PFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSY 446 S RD + +P++FK R + ++ +G G + CLG Sbjct: 261 LG-SANRDETFFDEPDLFKIGR-------------------REMHLAFGIGIHMCLGAPL 300 Query: 447 AVNSIKQFVFLVLVHLD 463 A + +L H Sbjct: 301 ARLEASIALNDILNHFK 317 >5KYO-A nrPDB Length = 430 Score = 56.8 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 38/267 (14%), Positives = 74/267 (27%), Gaps = 57/267 (21%) Query: 232 SVKSRLWKLLSPARLARRAHRSKWLESYLLHLE--EMGVSEEMQARALVLQLWATQGNMG 289 V + + L P ARR + + S +++ E +++ + L + Sbjct: 217 DVTKQFREYLRPVIEARRIKPGEDMISRMINGEVGGRPLTDIEAENICIQVLVGGLDTVV 276 Query: 290 PAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESL 349 + L K L + + ++D L E Sbjct: 277 NMLGFTFSHLAK-------------------------DHALRRAIAADPSLIDDALLEFF 311 Query: 350 RLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRF 409 R REV+ D E L + +++ P + D DP F+ R Sbjct: 312 RRFPVVSSAREVLRDQEF------EGVLLKAGDMVMAPTVVVAMDDARNEDPLEFRLGR- 364 Query: 410 LNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINA 469 + +G G + C G A +K + + Sbjct: 365 -----------------KARQHSTFGKGSHTCPGAHLARMEMKVVLREWFARI------P 401 Query: 470 DVEIPEFDLSRYGFGLMQPEHDVPVRY 496 + I + RY G++ + + Sbjct: 402 EFRIEDDAPLRYSNGIVGSVKPFVLEW 428 >2FR7-A nrPDB Length = 412 Score = 56.0 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 27/198 (13%), Positives = 62/198 (31%), Gaps = 50/198 (25%) Query: 264 EEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQP 323 + ++ E + L A + L + P+ A +R Sbjct: 232 DTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRA------------ 279 Query: 324 VSQTTTLPQKVLDSTPVLDSVLSESLRL-TAAPFITREVVVDLAMPMADGREFNLRRGDR 382 +L + + E++R + R D+ + + G++ Sbjct: 280 ---DPSLARNAFE----------EAVRFESPVQTFFRTTTRDVEL-----AGATIGEGEK 321 Query: 383 LLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCL 442 +L+F S RDP + DP+ + R + ++ +G+G + C+ Sbjct: 322 VLMFLG-SANRDPRRWDDPDRYDITR------------------KTSGHVGFGSGVHMCV 362 Query: 443 GRSYAVNSIKQFVFLVLV 460 G+ A + + + Sbjct: 363 GQLVARLEGEVVLAALAR 380 >5OMS-A nrPDB Length = 409 Score = 54.5 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 64/424 (15%), Positives = 121/424 (28%), Gaps = 85/424 (20%) Query: 45 DFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLM 104 ++ R++ + F + V G YV S V E T DF A Sbjct: 21 QLERNPYEVYERLRAEAPLAF-VPVLGSYVA------STAEVCREVATSPDFEAVITPAG 73 Query: 105 ERIFDV----QLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWH 160 R F + +D ++ ++ L E+ +L + E Sbjct: 74 GRTFGHPAIIGVNGDIHADLRSMVEPALQPAEVDRW----IDDLVRPIARRYLERFENDG 129 Query: 161 EMGLL-DFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLAR 219 L+ + +R+ G + V S + F +L+R A Sbjct: 130 HAELVAQYCEPVSVRS-----LGDLLGLQ--------EVDSDKLREWFAKLNRSFTNAAV 176 Query: 220 ----GSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGV----SEE 271 + K+ + ++ P H S+ LH + M E Sbjct: 177 DENGEFANPEGFAEGDQAKAEIRAVVDPLIDKWIEHPDDSAISHWLH-DGMPPGQTRDRE 235 Query: 272 MQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLP 331 + + L G L+ L PE L V Sbjct: 236 YIYPTIYVYLLGAMQEPGHGMASTLVGLFSRPEQLEEV---------------------- 273 Query: 332 QKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSP 391 +D ++ ++E LR T+ ++ +L G ++L + S Sbjct: 274 ---VDDPTLIPRAIAEGLRWTSP---IWSATARISTKPVTIAGVDLPAGTPVMLS-YGSA 326 Query: 392 QRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSI 451 D Y P + +R ++ +GAG++ C G +A + + Sbjct: 327 NHDTGKYEAPSQYDLHR------------------PPLPHLAFGAGNHACAGIYFANHVM 368 Query: 452 KQFV 455 + + Sbjct: 369 RIAL 372 >4DO1-A nrPDB Length = 410 Score = 53.3 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 23/139 (16%), Positives = 52/139 (37%), Gaps = 32/139 (23%) Query: 347 ESLRLTAAPFITREVVVDLAMPMADGREF-------------NLRRGDRLLLFPFLSPQR 393 E RL + P + R + + + F + G+++L+F S R Sbjct: 271 ELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLG-SANR 329 Query: 394 DPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQ 453 DP ++DP+++ R + ++ +G+G + C+G+ A + Sbjct: 330 DPRRWSDPDLYDITR------------------KTSGHVGFGSGVHMCVGQLVARLEGEV 371 Query: 454 FVFLVLVHLDLELINADVE 472 + + + I+ V+ Sbjct: 372 MLSALARKVAAIDIDGPVK 390 >5HH3-A nrPDB Length = 397 Score = 53.3 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 37/269 (13%), Positives = 79/269 (29%), Gaps = 53/269 (19%) Query: 214 LPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQ 273 L + S + + ++ ++ R + ++ +++ Sbjct: 169 LARSLHASRTERSGKRRTAAGNKFMTYMNKMTARTRRDPGDDMFGVVVREYGDEITDAEL 228 Query: 274 ARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQK 333 + A + + +PE A +R + +++ Sbjct: 229 TGVAAFVMGAGADQVARFLAAGAWLMADDPEQFALLREKPDTVPDW-------------- 274 Query: 334 VLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQR 393 L E +R T +A + ++ GD + + +R Sbjct: 275 -----------LDEVIRYLTTDEKTH---PRVATDDVRIGDHLIKAGDTVTCSLLAANRR 320 Query: 394 DPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQ 453 + + PE +RF D R++ ++ +G G +HCLGRS A + Sbjct: 321 N---FPRPE----DRF-------------DITRVRPEHLAFGHGIHHCLGRSLAELVFRT 360 Query: 454 FVFLVLVHL-DLELINADVE----IPEFD 477 + + L L E P FD Sbjct: 361 AIPALAHRFPTLRLAEPHREIRLGPPPFD 389 >6HQW-A nrPDB Length = 445 Score = 51.8 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 32/206 (15%), Positives = 69/206 (33%), Gaps = 50/206 (24%) Query: 252 RSKWLESYLLHLEEMG-VSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVR 310 S L S ++H E M +S + LVL + ++ L K P+ + Sbjct: 251 PSGDLISMMIHSEAMNHMSPQEFMGNLVLLIVGGNDTTRNTMSGIVHALDKFPD-QRELL 309 Query: 311 GELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-TAAPFITREVVVDLAMPM 369 S++ A + E +R T + R D + Sbjct: 310 ERDASLIPNA------------------------VQECIRYVTPLAHMRRTATADTELFG 345 Query: 370 ADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKN 429 ++ G++++L+ ++S RD ++ +P+ +R Sbjct: 346 NQ-----IKAGEKVILW-YISANRDETVFENPDKLMVDR-----------------PNAR 382 Query: 430 YNMPWGAGHNHCLGRSYAVNSIKQFV 455 ++ +G G + C+G A ++ + Sbjct: 383 RHLSFGHGIHRCVGARLAELQLRILL 408 >6M7L-A nrPDB Length = 404 Score = 51.8 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 36/272 (13%), Positives = 78/272 (28%), Gaps = 51/272 (18%) Query: 217 LARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARA 276 L R + G K + R + + +S+E A Sbjct: 178 LIRLTAHRGGKRRRVLNGHAYLAYMRELAARLRRDPGDGMLGMVARDHGADISDEELAGL 237 Query: 277 LVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLD 336 + + ++ L LL++PE A +R + Sbjct: 238 CAVVMNSSVEQTESCLAAGTLLLLEHPEQFALLRE---------RPELG----------- 277 Query: 337 STPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPE 396 + + E +R + + + A + +++G+ + + + DP Sbjct: 278 -----EQAVEEIVRYLS---VFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAANRADPA 329 Query: 397 IYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVF 456 + + F R ++ ++ +G G +HCLG A ++ Sbjct: 330 L----DGFDITR------------------KESRHVAFGHGIHHCLGAPLARMELRIAFT 367 Query: 457 LVLVHL-DLELINADVEIPEFDLSRYGFGLMQ 487 ++ L EI S F L++ Sbjct: 368 TLVSRFPSLRTAVPAEEIRFRPPSSNVFTLLE 399 >5H1Z-A nrPDB Length = 407 Score = 49.5 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 29/236 (12%), Positives = 65/236 (27%), Gaps = 49/236 (20%) Query: 220 GSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVL 279 L + HM L A++ + + + + + L+L Sbjct: 184 EELRLERLRHMYECGGYFQN-LWNAKIGKPPTP-DLISMMIHSDAMAEMDQMEFLGNLIL 241 Query: 280 QLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTP 339 + + L P+ A + + I Sbjct: 242 LIVGGNDTTRNTMSAVAYGLDLFPDQRAKLEADPSMIP---------------------- 279 Query: 340 VLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYT 399 + + E +R R A ++ ++ GD+L L+ ++S RD ++ Sbjct: 280 ---NTVQEIIRWQTPLAHMR----RTATVDSELEGQQIKAGDKLALW-YISANRDESVFE 331 Query: 400 DPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFV 455 + + +R ++ +G G + C+G A I + Sbjct: 332 NADRIIVDR-----------------PNARRHLAFGHGIHRCVGARLAELQIAVLL 370 >3WEC-A nrPDB Length = 419 Score = 49.5 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 40/293 (13%), Positives = 90/293 (30%), Gaps = 66/293 (22%) Query: 198 VHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLE 257 +++ ++ +PK + ++ L+ + A + E Sbjct: 176 SEWSNLVAGVLDINFAIPKEVADR-----RSAAIEESIDYFRTLATSGNAPEGLVRRLSE 230 Query: 258 SYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESIL 317 +S + A +L A Q +L+ ++ + VR Sbjct: 231 VS---HGGDQLSVDEIAATCLLITVAGQETTSNTIGNMLITFSRHADQFEQVRA------ 281 Query: 318 WQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNL 377 + +++ ++E LR +A+ + N+ Sbjct: 282 -------------------NPQFIENAVAEVLRFEPPAHEAG----RIALEDCEVSGANI 318 Query: 378 RRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAG 437 +GD +++ L+ N + E+ D + R ++ +G G Sbjct: 319 TKGDAVMV--LLASG------------------NREAVERGDTFSVT-RPDVSSLSYGRG 357 Query: 438 HNHCLGRSYAVNSIKQFVFLVLVHL-DLELINADVEIPEFDLSRYGFGLMQPE 489 +HCLG + A + ++ F+ + +E+ P G GL PE Sbjct: 358 IHHCLGSALANSMLQHFLRELSQRYRSIEVAEPINYKP-------GMGLRGPE 403 >5D3U-A nrPDB Length = 427 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 24/122 (19%), Positives = 40/122 (32%), Gaps = 22/122 (18%) Query: 341 LDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTD 400 +D+ +E LR A+ T +A + + G L LF S RD ++ Sbjct: 300 VDNTANEVLRYNASNQFTW----RVAAKDVEMGGVRIEAGQTLALFLG-SANRDANMFER 354 Query: 401 PEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLV 460 P F +R ++ +G G + CL +K F +L Sbjct: 355 PNDFDLDR-----------------PNSARHLSFGQGVHACLAAQLISLQLKWFYVALLN 397 Query: 461 HL 462 Sbjct: 398 RF 399 >5EX8-A nrPDB Length = 424 Score = 45.6 bits (106), Expect = 5e-05, Method: Composition-based stats. Identities = 38/269 (14%), Positives = 75/269 (27%), Gaps = 53/269 (19%) Query: 214 LPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQ 273 L ++ S + + ++ + R L + +++ Sbjct: 196 LARILLASRTDRSDKRRTAAGNKFMTYMKQHVAQSRRGSGDDLFGIVGRENGDAITDAEL 255 Query: 274 ARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQK 333 + A + +++ P A +R + E++ Sbjct: 256 TGVAAFVMGAAADQVARLLAAGAWLMVEQPAQFALLREKPETVP---------------- 299 Query: 334 VLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQR 393 LD E++R T +A ++ GD + L+ R Sbjct: 300 -----EWLD----ETMRYLTTDEKTH---PRVATQDVRIGNQLVKAGDTVTCS-LLAANR 346 Query: 394 DPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQ 453 P + + F R K ++ +G G +HCLGR+ A K Sbjct: 347 -PNYPSAEDEFDITR------------------EKAEHLAFGHGIHHCLGRAMAELMFKV 387 Query: 454 FVFLVLVHL-DLELINADVE----IPEFD 477 + + L L + E P FD Sbjct: 388 SIPALAHRFPTLRLADPQREITLGPPPFD 416 >2UUQ-A nrPDB Length = 414 Score = 44.5 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 35/274 (12%), Positives = 73/274 (26%), Gaps = 54/274 (19%) Query: 204 FHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHL 263 + Q D + + G + + RR + S+L+ Sbjct: 167 EEDWTQFDGWTQAIVAANAVDGATTGALDAVGSMMAYFTGLIERRRTEPADDAISHLVAA 226 Query: 264 ----EEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQ 319 + + + + L + P+ + + E I Sbjct: 227 GVGADGDTAGTLSILAFTFTMVTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEGIP-- 284 Query: 320 AEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPF-ITREVVVDLAMPMADGREFNLR 378 D+V E LRLT+ + R D+ + + + Sbjct: 285 ----------------------DAV-EELLRLTSPVQGLARTTTRDVTI-----GDTTIP 316 Query: 379 RGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGH 438 G R+LL + + + + D R + + G Sbjct: 317 AGRRVLLLYGSANRDERQYGPDAAELDVTR------------------CPRNILTFSHGA 358 Query: 439 NHCLGRSYAVNSIKQFVFLVLVHL-DLELINADV 471 +HCLG + A + + +L D E+ + + Sbjct: 359 HHCLGAAAARMQCRVALTELLARCPDFEVAESRI 392 >4FB2-A nrPDB Length = 398 Score = 44.1 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 33/243 (13%), Positives = 68/243 (27%), Gaps = 57/243 (23%) Query: 232 SVKSRLWKLLSPARL---ARRAHRSKWLESYLL--HLEEMGVSEEMQARALVLQLWATQG 286 +L++ AR RR + + S ++ ++ +SE+ + L Sbjct: 176 EGAEIFAELVAHARTLIAERRTNPGNDIMSRVIMSKIDGESLSEDDLIGFFTILLLGGID 235 Query: 287 NMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLS 346 N + L L ++++ ++ + + Sbjct: 236 NTARFLSSVFWRLA-------------------------WDIELRRRLIAHPELIPNAVD 270 Query: 347 ESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKY 406 E LR + R V ++ + + +L FP S RD + P+ Sbjct: 271 ELLRFYGPAMVGRLVTQEVTVGDITMK----PGQTAMLWFPIAS--RDRSAFDSPDNIVI 324 Query: 407 NRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVH---LD 463 R N ++ G G + CLG + + L Sbjct: 325 ER------------------TPNRHLSLGHGIHRCLGAHLIRVEARVAITEFLKRIPEFS 366 Query: 464 LEL 466 L+ Sbjct: 367 LDP 369 >2IJ7-A nrPDB Length = 396 Score = 44.1 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 34/221 (15%), Positives = 67/221 (30%), Gaps = 50/221 (22%) Query: 244 ARLARRAHRSKWLESYLLHLEEMG----VSEEMQARALVLQLWATQGNMGPAAFWLLLFL 299 A + + + L L L + VS+E+ A V A + G L+ L Sbjct: 190 AGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISL 249 Query: 300 LKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITR 359 ++ P+ + + E I + E LR+ Sbjct: 250 IQRPQLRNLLHEKPELIPAG-------------------------VEELLRIN---LSFA 281 Query: 360 EVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKD 419 + + LA + +R+G+ +L+ + F F NP E Sbjct: 282 DGLPRLATADIQVGDVLVRKGELVLVLLEGA------------NFDPEHFPNPGSIE--- 326 Query: 420 FYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLV 460 + ++ +G G + C G + + + +L Sbjct: 327 ---LDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLK 364 >6BLD-A nrPDB Length = 419 Score = 42.5 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 53/385 (13%), Positives = 109/385 (28%), Gaps = 80/385 (20%) Query: 82 SYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMY 141 + L + + M+ P ++ + + R+++ + +++ Sbjct: 83 GNGVLFENVPAELLEASQSFLAMDP------PRHTKL--RKLVSAAFTPRQVRRIEDSIK 134 Query: 142 TNLHAVLLGDATEAGSGWHEMGLLDFSY-SFLLRAGYLTLYGIEALPRTHESQAQDRVHS 200 N ++ + AG G + ++ +R + EA A V Sbjct: 135 IN-AKGIVDELRMAGGG---VDFVEHCAKELPIRTLSDMVGIPEADRERVAHAADALVSW 190 Query: 201 AD--VFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLES 258 AD + L L ++ ++ V + L RR L S Sbjct: 191 ADPRYLNGREPLAVLF----------ENQMYLHQVAASLAA-------ERRDRPGDDLFS 233 Query: 259 YLL--HLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESI 316 L+ ++ +++ A VL A L L P A + + ++ Sbjct: 234 ALVNAEVDGDRLADADVAAFFVLLAVAGNDTTRQTISHGLKALTDFPSQKAWLLADFDTR 293 Query: 317 LWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFN 376 + A + E +R R A + Sbjct: 294 IGTA------------------------VEELVRWATPVMTFR----RTAAADFELGGQL 325 Query: 377 LRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGA 436 +R G+++++F + S D + + PE +R NP Sbjct: 326 IRAGEKVVMF-YASGNWDEDAFCHPERLDLSRSPNPHVGFGGGGVHF------------- 371 Query: 437 GHNHCLGRSYAVNSIKQFVFLVLVH 461 CLG A ++ +LV Sbjct: 372 ----CLGAHLARAQLRAIFGELLVQ 392 >2YJN-B nrPDB Length = 381 Score = 32.1 bits (71), Expect = 0.52, Method: Composition-based stats. Identities = 18/96 (18%), Positives = 39/96 (40%), Gaps = 10/96 (10%) Query: 313 LESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADG 372 ++++L + +P L +++ D ++E LRL A + R A Sbjct: 232 VDAVLAVSAEP-----GLAERIADDPAAAQRTVAEVLRLHPALHLER----RTATAEVRL 282 Query: 373 REFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNR 408 E + ++ + RDPE++ +P+ +R Sbjct: 283 GEHVIGE-GEEVVVVVAAANRDPEVFAEPDRLDVDR 317 >1H2T-C nrPDB Length = 723 Score = 31.4 bits (69), Expect = 0.92, Method: Composition-based stats. Identities = 23/107 (21%), Positives = 38/107 (35%), Gaps = 16/107 (14%) Query: 310 RGELESILWQAEQPVSQTTTLPQKVLDSTPVL--DSVLSESLRLTAAPFITREVVVDLAM 367 + E LW Q + + + +L P L DS+L E+L+ PF Sbjct: 206 QEEYLDCLWAQIQKLKKDRWQERHILR--PYLAFDSILCEALQHNLPPFTPP-------- 255 Query: 368 PMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDG 414 P + + + R ++F DPE P RF+ + Sbjct: 256 PHTEDSVYPMPR----VIFRMFDYTDDPEGPVMPGSHSVERFVIEEN 298 >5OVN-A nrPDB Length = 532 Score = 31.0 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 16/97 (16%), Positives = 42/97 (43%), Gaps = 3/97 (3%) Query: 234 KSRLWKLLSPARLARRAHRSKWLESYL-LHLEEMGVSEEMQARALVLQLWATQG--NMGP 290 + W + +L + A + W ++ +E G +++ + +AL+L L A N+ Sbjct: 419 GAETWYIDGGRKLGKAAKAAYWTDTGKWQVMELEGSNQKAEIQALLLALKAGSEEMNIIT 478 Query: 291 AAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQT 327 + +++ +L+ P+ + + E+ L + Sbjct: 479 DSQYVINIILQQPDMMEGIWQEVLEELEKKTAIFIDW 515 >4KVO-A nrPDB Length = 731 Score = 30.6 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 16/137 (11%), Positives = 40/137 (29%), Gaps = 13/137 (9%) Query: 186 LPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPAR 245 +E + + SA+ + + QL + PK + +K + + L Sbjct: 264 RAYGYEDASGKVLDSAEWLNLYSQLAKRYPKSECPTRLPLEKLEGDEFLTHVDLYLRKKL 323 Query: 246 LARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMG-----------PAAFW 294 +R S +++ L+ + + +T W Sbjct: 324 --KRGIPSVFVDVKSLYKDTKKCKVVEDLVSKYASSLSTTNKFSEDDDNSQIEIPTTLLW 381 Query: 295 LLLFLLKNPEALAAVRG 311 FL ++ + + + Sbjct: 382 TYYFLAQHFDHVGELEK 398 >5C8J-I nrPDB Length = 207 Score = 30.2 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 6/19 (31%), Positives = 12/19 (63%) Query: 299 LLKNPEALAAVRGELESIL 317 + KNPE + ++ E + I+ Sbjct: 71 MSKNPEMMEKLQEEQQRIM 89 >2Y05-A nrPDB Length = 328 Score = 29.4 bits (64), Expect = 3.3, Method: Composition-based stats. Identities = 16/85 (18%), Positives = 27/85 (31%), Gaps = 12/85 (14%) Query: 322 QPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMA----------D 371 P + L L + VL E+L LT P++ R L + Sbjct: 15 YPTNSDFELKTSELPPLKNGE-VLLEALFLTVDPYM-RVAAKRLKEGDTMMGQQVAKVVE 72 Query: 372 GREFNLRRGDRLLLFPFLSPQRDPE 396 + L +G +L P + + Sbjct: 73 SKNVALPKGTIVLASPGWTTHSISD 97 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.118 0.290 Lambda K H 0.267 0.0360 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,133,155 Number of Sequences: 36641 Number of extensions: 600977 Number of successful extensions: 2317 Number of sequences better than 10.0: 173 Number of HSP's better than 10.0 without gapping: 193 Number of HSP's successfully gapped in prelim test: 50 Number of HSP's that attempted gapping in prelim test: 1659 Number of HSP's gapped (non-prelim): 280 length of query: 500 length of database: 10,336,785 effective HSP length: 101 effective length of query: 399 effective length of database: 6,636,044 effective search space: 2647781556 effective search space used: 2647781556 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 61 (28.3 bits)