BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q16555 (572 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5YZA-A nrPDB 1089 0.0 4CNT-A nrPDB 949 0.0 5NKS-A nrPDB 935 0.0 1KCX-A nrPDB 853 0.0 4CNS-A nrPDB 823 0.0 2VR2-A nrPDB 650 0.0 4LCQ-A nrPDB 605 e-173 4B90-A nrPDB 603 e-173 4B91-A nrPDB 543 e-155 2FTW-A nrPDB 531 e-151 6AJD-A nrPDB 436 e-122 3DC8-A nrPDB 428 e-120 4TQT-A nrPDB 419 e-117 1YNY-A nrPDB 340 1e-93 1K1D-A nrPDB 322 4e-88 3SFW-A nrPDB 320 1e-87 1GKQ-A nrPDB 315 3e-86 1NFG-A nrPDB 252 4e-67 2FTY-A nrPDB 207 1e-53 1GKR-A nrPDB 140 2e-33 3HM7-A nrPDB 130 1e-30 3E74-A nrPDB 110 2e-24 3GRI-A nrPDB 95 9e-20 3MPG-A nrPDB 85 9e-17 1XRT-A nrPDB 75 6e-14 2Z00-A nrPDB 54 2e-07 2GWN-A nrPDB 54 2e-07 6HG1-A nrPDB 46 4e-05 5T5I-A nrPDB 42 5e-04 4CEX-C nrPDB 40 0.002 2VHL-A nrPDB 40 0.003 3QGK-C nrPDB 38 0.012 3OOQ-A nrPDB 37 0.018 4WGX-A nrPDB 37 0.023 2PUZ-A nrPDB 36 0.038 1FWC-C nrPDB 35 0.10 3MKV-A nrPDB 33 0.48 4H9M-A nrPDB 32 0.96 3N2C-A nrPDB 32 1.1 1E9Y-B nrPDB 30 2.6 3MWY-W nrPDB 30 3.1 2BB0-A nrPDB 30 3.2 2EX6-A nrPDB 30 3.7 4QKD-A nrPDB 29 6.7 4Z42-C nrPDB 28 9.2 4V1Y-A nrPDB 28 10.0 >5YZA-A nrPDB Length = 525 Score = 1089 bits (2816), Expect = 0.0, Method: Compositional matrix adjust. Identities = 524/525 (99%), Positives = 524/525 (99%) Query: 1 MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEA 60 MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEA Sbjct: 1 MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEA 60 Query: 61 HSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAF 120 HSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAF Sbjct: 61 HSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAF 120 Query: 121 DQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQ 180 DQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQ Sbjct: 121 DQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQ 180 Query: 181 IYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAI 240 IYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAI Sbjct: 181 IYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAI 240 Query: 241 TIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAA 300 TIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAA Sbjct: 241 TIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAA 300 Query: 301 FVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEE 360 FVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEE Sbjct: 301 FVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEE 360 Query: 361 RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI 420 RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI Sbjct: 361 RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI 420 Query: 421 SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYK 480 SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYK Sbjct: 421 SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYK 480 Query: 481 RIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAK 525 RIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKT PAK Sbjct: 481 RIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTDPAK 525 >4CNT-A nrPDB Length = 570 Score = 949 bits (2454), Expect = 0.0, Method: Compositional matrix adjust. Identities = 437/571 (76%), Positives = 517/571 (90%), Gaps = 2/571 (0%) Query: 1 MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEA 60 MSYQGKKNIPRITSDRLLIKGG+IVNDDQSFYADIYMEDGLIKQIG+NLIVPGGVKTIEA Sbjct: 1 MSYQGKKNIPRITSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEA 60 Query: 61 HSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAF 120 + +MVIPGGIDVHT +QMP +GMT+ DDFFQGTKAALAGGTTMIIDHVVPEP +SL A+ Sbjct: 61 NGKMVIPGGIDVHTHYQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAY 120 Query: 121 DQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQ 180 ++WREWAD KSCCDY+LHVDI+ W+ +++E++ L+KD GVNSF+VYMA+KD +Q+++ + Sbjct: 121 EKWREWADGKSCCDYALHVDITHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTE 180 Query: 181 IYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAI 240 +YE+ + + ++GAIAQVHAENGDIIA+EQ R+L++GITGPEGHVLSRPEE+EAEAV RAI Sbjct: 181 LYEIFTCLGELGAIAQVHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAI 240 Query: 241 TIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAA 300 TIA+QTNCPLY+TKVMSKS+A++I+QARKKG VV+GEPITASLG DG+HYWSKNWAKAAA Sbjct: 241 TIASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAA 300 Query: 301 FVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEE 360 FVTSPPLSPDPTTPD++NSLL+ GDLQ++GSAHCTF+TAQKA+GKDNFT IPEGTNG EE Sbjct: 301 FVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEE 360 Query: 361 RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI 420 RMSVIWDKAV TGKMDENQFVAVTSTNAAK+FNLYPRKGRI+VGSD+DLVIWDPD+VK + Sbjct: 361 RMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKIV 420 Query: 421 SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYK 480 SAK H S+ EYNIFEGME RG+PLVVI QGKI+LEDG LHVT+G+GR+IP PF D+VYK Sbjct: 421 SAKNHQSAAEYNIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYK 480 Query: 481 RIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFS 540 RIKAR ++A+L VPRG+YDGPV +++ TPK TPA SA+ SP + PPVRNLHQSGFS Sbjct: 481 RIKARRKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSARGSPTRPN-PPVRNLHQSGFS 539 Query: 541 LSGAQIDDNIPRRTTQRIVAPPGGRANITSL 571 LSG Q+D+ + R ++RIVAPPGGR+NITSL Sbjct: 540 LSGTQVDEGV-RSASKRIVAPPGGRSNITSL 569 >5NKS-A nrPDB Length = 573 Score = 935 bits (2416), Expect = 0.0, Method: Compositional matrix adjust. Identities = 432/571 (75%), Positives = 504/571 (88%) Query: 1 MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEA 60 MS+QGKK+IPRITSDRLLI+GG+IVNDDQSFYAD+++EDGLIKQIGENLIVPGG+KTI+A Sbjct: 2 MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDA 61 Query: 61 HSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAF 120 H MV+PGG+DVHTR QMP GMT ADDF QGTKAALAGGTTMI+DHV P+ G SLLAA+ Sbjct: 62 HGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAY 121 Query: 121 DQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQ 180 +QWRE ADS +CCDYSLHVDI+ WH+ I+EE+EALVK+ GVNSFLV+MA+KDR Q +D Q Sbjct: 122 EQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQ 181 Query: 181 IYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAI 240 +YE+ S+IRD+GA+AQVHAENGDI+ EEQ+R+L+LGITGPEGHVLS PEEVEAEAV RA+ Sbjct: 182 MYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAV 241 Query: 241 TIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAA 300 TIA Q NCPLY+TKVMSK +A+ IAQA+++G VV+GEPITASLGTDGSHYWSKNWAKAAA Sbjct: 242 TIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAA 301 Query: 301 FVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEE 360 FVTSPP++PDPTT D L LLS GDLQVTGSAHCTF TAQKAVGKDNF LIPEGTNG EE Sbjct: 302 FVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEE 361 Query: 361 RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI 420 RMS++W+K V +GKMDEN+FVAVTSTNAAK+FN YPRKGR+AVGSDADLVIW+P + K I Sbjct: 362 RMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKII 421 Query: 421 SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYK 480 SAKTHN ++EYNIFEG+ECRG+P VVISQG++ LEDG + VT G+GR++PRK FPDFVYK Sbjct: 422 SAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYK 481 Query: 481 RIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFS 540 RIKAR+RLAE+ GVPRGLYDGPV EV V K + A + + P K PPVRNLHQSGFS Sbjct: 482 RIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGKISVPPVRNLHQSGFS 541 Query: 541 LSGAQIDDNIPRRTTQRIVAPPGGRANITSL 571 LSG+Q DD+I RRT Q+I+APPGGR+NITSL Sbjct: 542 LSGSQADDHIARRTAQKIMAPPGGRSNITSL 572 >1KCX-A nrPDB Length = 518 Score = 853 bits (2205), Expect = 0.0, Method: Compositional matrix adjust. Identities = 391/518 (75%), Positives = 461/518 (88%) Query: 8 NIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIP 67 +IP ITSDRLLI+GG+I+NDDQSFYAD+Y+EDGLIKQIGENLIVPGGVKTIEA+ RMVIP Sbjct: 1 SIPHITSDRLLIRGGRIINDDQSFYADVYLEDGLIKQIGENLIVPGGVKTIEANGRMVIP 60 Query: 68 GGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWA 127 GGIDV+T Q P QGMTSADDFFQGTKAALAGGTTMIIDHVVPEPG+SLL +F++W E A Sbjct: 61 GGIDVNTYLQKPSQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGSSLLTSFEKWHEAA 120 Query: 128 DSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSV 187 D+KSCCDYSLHVDI+ W+ G++EE+E LV+D GVNSF VYMA+KD +Q++D Q+YE + Sbjct: 121 DTKSCCDYSLHVDITSWYDGVREELEVLVQDKGVNSFQVYMAYKDLYQMSDSQLYEAFTF 180 Query: 188 IRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTN 247 ++ +GA+ VHAENGD+IA+EQ+RIL++GITGPEGH LSRPEE+EAEAV RAI IA + N Sbjct: 181 LKGLGAVILVHAENGDLIAQEQKRILEMGITGPEGHALSRPEELEAEAVFRAIAIAGRIN 240 Query: 248 CPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPL 307 CP+YITKVMSKS+A++IA ARKKG +V+GEPI ASLGTDG+HYWSKNWAKAAAFVTSPPL Sbjct: 241 CPVYITKVMSKSAADIIALARKKGPLVFGEPIAASLGTDGTHYWSKNWAKAAAFVTSPPL 300 Query: 308 SPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWD 367 SPDPTTPD+L SLL+CGDLQVTGS HC ++TAQKAVGKDNFTLIPEG NG EERM+V+WD Sbjct: 301 SPDPTTPDYLTSLLACGDLQVTGSGHCPYSTAQKAVGKDNFTLIPEGVNGIEERMTVVWD 360 Query: 368 KAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNS 427 KAV TGKMDENQFVAVTSTNAAK+FNLYPRKGRIAVGSDAD+VIWDPD +KTI+AK+H S Sbjct: 361 KAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDADVVIWDPDKMKTITAKSHKS 420 Query: 428 SLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSR 487 ++EYNIFEGMEC GSPLVVISQGKIV EDG + V++G GR+IPRKPFP+ +Y+R++ RS+ Sbjct: 421 TVEYNIFEGMECHGSPLVVISQGKIVFEDGNISVSKGMGRFIPRKPFPEHLYQRVRIRSK 480 Query: 488 LAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAK 525 + L V RG+YDGPV EV TPK PA SAK+SP+K Sbjct: 481 VFGLHSVSRGMYDGPVYEVPATPKHAAPAPSAKSSPSK 518 >4CNS-A nrPDB Length = 480 Score = 823 bits (2125), Expect = 0.0, Method: Compositional matrix adjust. Identities = 373/479 (77%), Positives = 442/479 (92%) Query: 12 ITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGID 71 +TSDRLLIKGG+IVNDDQSFYADIYMEDGLIKQIG+NLIVPGGVKTIEA+ +MVIPGGID Sbjct: 2 MTSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEANGKMVIPGGID 61 Query: 72 VHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKS 131 VHT +QMP +GMT+ DDFFQGTKAALAGGTTMIIDHVVPEP +SL A+++WREWAD KS Sbjct: 62 VHTHYQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAYEKWREWADGKS 121 Query: 132 CCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDI 191 CCDY+LHVDI+ W+ +++E++ L+KD GVNSF+VYMA+KD +Q+++ ++YE+ + + ++ Sbjct: 122 CCDYALHVDITHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTELYEIFTCLGEL 181 Query: 192 GAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLY 251 GAIAQVHAENGDIIA+EQ R+L++GITGPEGHVLSRPEE+EAEAV RAITIA+QTNCPLY Sbjct: 182 GAIAQVHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAITIASQTNCPLY 241 Query: 252 ITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDP 311 +TKVMSKS+A++I+QARKKG VV+GEPITASLG DG+HYWSKNWAKAAAFVTSPPLSPDP Sbjct: 242 VTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAAFVTSPPLSPDP 301 Query: 312 TTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVV 371 TTPD++NSLL+ GDLQ++GSAHCTF+TAQKA+GKDNFT IPEGTNG EERMSVIWDKAV Sbjct: 302 TTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVA 361 Query: 372 TGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEY 431 TGKMDENQFVAVTSTNAAK+FNLYPRKGRI+VGSD+DLVIWDPD+VK +SAK H S+ EY Sbjct: 362 TGKMDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKIVSAKNHQSAAEY 421 Query: 432 NIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAE 490 NIFEGME RG+PLVVI QGKI+LEDG LHVT+G+GR+IP PF D+VYKRIKAR ++A+ Sbjct: 422 NIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYKRIKARRKMAD 480 >2VR2-A nrPDB Length = 541 Score = 650 bits (1677), Expect = 0.0, Method: Compositional matrix adjust. Identities = 311/519 (59%), Positives = 389/519 (74%), Gaps = 9/519 (1%) Query: 16 RLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGG----VKTIEAHSRMVIPGGID 71 RLLI+GG++VNDD S AD+ +EDG+++ +G +L+ PGG ++ ++A ++V+PGGID Sbjct: 28 RLLIRGGRVVNDDFSEVADVLVEDGVVRALGHDLLPPGGAPAGLRVLDAAGKLVLPGGID 87 Query: 72 VHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKS 131 HT Q P G S DDF QGTKAAL+GGTTMIID +P+ G SL+ AF+ WR WAD K Sbjct: 88 THTHMQFPFMGSRSIDDFHQGTKAALSGGTTMIIDFAIPQKGGSLIEAFETWRSWADPKV 147 Query: 132 CCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDI 191 CCDYSLHV ++ W ++EEM+ LV+D GVNSF ++MA+KD + +TD ++YE S ++I Sbjct: 148 CCDYSLHVAVTWWSDQVKEEMKILVQDKGVNSFKMFMAYKDLYMVTDLELYEAFSRCKEI 207 Query: 192 GAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLY 251 GAIAQVHAENGD+IAE +++L LGITGPEGH L RPE VEAEA RAITIA+ NCPLY Sbjct: 208 GAIAQVHAENGDLIAEGAKKMLALGITGPEGHELCRPEAVEAEATLRAITIASAVNCPLY 267 Query: 252 ITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDP 311 I VMSKS+A+VIA AR+ G VVYGEPI ASLGTDG+HYW+K W AA V PPL PDP Sbjct: 268 IVHVMSKSAAKVIADARRDGKVVYGEPIAASLGTDGTHYWNKEWHHAAHHVMGPPLRPDP 327 Query: 312 TTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVV 371 +TPDFL +LL+ DL TG+ +CTFNT QKA+GKD+FT IP G NG E+RMSVIW+K V Sbjct: 328 STPDFLMNLLANDDLTTTGTDNCTFNTCQKALGKDDFTKIPNGVNGVEDRMSVIWEKGVH 387 Query: 372 TGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEY 431 +GKMDEN+FVAVTSTNAAK+FNLYPRKGRIAVGSDAD+VIWDP +TISAKTH+ ++ + Sbjct: 388 SGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIVIWDPKGTRTISAKTHHQAVNF 447 Query: 432 NIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAEL 491 NIFEGM C G PLV IS+GK+V E G VT G G++IPRKPF +++YKRIK R R Sbjct: 448 NIFEGMVCHGVPLVTISRGKVVYEAGVFSVTAGDGKFIPRKPFAEYIYKRIKQRDRTCTP 507 Query: 492 RGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPP 530 V R Y G EV+ VT + T+ ++QA P Sbjct: 508 TPVERAPYKG---EVATLKSRVTKEDA--TAGTRKQAHP 541 >4LCQ-A nrPDB Length = 520 Score = 605 bits (1559), Expect = e-173, Method: Compositional matrix adjust. Identities = 281/493 (56%), Positives = 373/493 (75%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRF 76 +LIKGGK+VN+D SF++D+++ G I ++G +L VP G + I+A R+VIPGGID HT Sbjct: 27 ILIKGGKVVNEDCSFFSDVHIRGGKIVEVGPDLRVPPGARVIDATDRLVIPGGIDTHTHM 86 Query: 77 QMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYS 136 ++ G + DDF GTKAALAGGTTMI+D V+ + G SLL A+D WR+ AD K CCDYS Sbjct: 87 ELAFMGTRAVDDFHIGTKAALAGGTTMILDFVMTQKGQSLLEAYDLWRKTADPKVCCDYS 146 Query: 137 LHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQ 196 LHV ++ W +++EM L ++ GVNSF ++MA+K F L D ++Y V S +++GAIAQ Sbjct: 147 LHVAVTWWSDEVKDEMRTLAQERGVNSFKMFMAYKGLFMLRDDELYAVFSHCKEVGAIAQ 206 Query: 197 VHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVM 256 VHAENGD+IAE +++L LGITGPEGH L RPE VEAEA RAITIA+ NCPLY+ VM Sbjct: 207 VHAENGDLIAEGAKKMLSLGITGPEGHELCRPEAVEAEATQRAITIASAVNCPLYVVHVM 266 Query: 257 SKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDF 316 SKS+A+V+++ARK G VV+GEPI ASLGTDG++YW K+WA AA +V PPL PDP+TP + Sbjct: 267 SKSAADVVSKARKDGRVVFGEPIAASLGTDGTNYWHKDWAHAAQYVMGPPLRPDPSTPGY 326 Query: 317 LNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMD 376 L LL+ DL +TG+ +CTF+ QKA+GKD+FT IP G NG E+RMSVIW+K V +GKMD Sbjct: 327 LMDLLANDDLTLTGTDNCTFSRCQKALGKDDFTRIPNGVNGVEDRMSVIWEKGVHSGKMD 386 Query: 377 ENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEG 436 EN+FVAVTS+NAAK+FN YP+KGRIA SDAD+VIWDP + + ISA+TH+ +++YNIFEG Sbjct: 387 ENRFVAVTSSNAAKIFNFYPQKGRIAKDSDADVVIWDPKTTRKISAQTHHQAVDYNIFEG 446 Query: 437 MECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRGVPR 496 MEC G P+V +S+G++V E+G L V+ G GR+I R+PF +FVYKRI+ R + + V R Sbjct: 447 MECHGVPVVTVSRGRVVYEEGRLKVSPGQGRFIHRQPFSEFVYKRIRQRDEVGKPAVVIR 506 Query: 497 GLYDGPVCEVSVT 509 Y G V + + Sbjct: 507 EPYAGEVVALGTS 519 >4B90-A nrPDB Length = 586 Score = 603 bits (1555), Expect = e-173, Method: Compositional matrix adjust. Identities = 290/557 (52%), Positives = 396/557 (71%), Gaps = 5/557 (0%) Query: 14 SDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVH 73 S R+LIKGGK+VNDD + AD+Y+E+G+I+Q+G L++PGG K I+A ++VIPGGID Sbjct: 29 SVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTS 88 Query: 74 TRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCC 133 T F T DDF+ GTKAAL GGTTMII HV+P+ TSL+ A+++ R AD K CC Sbjct: 89 THFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVDAYEKCRGLADPKVCC 148 Query: 134 DYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGA 193 DY+LHV I+ W ++ EME LV++ GVNSF ++M +KD + L D ++Y+VL +DIGA Sbjct: 149 DYALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVLHACKDIGA 208 Query: 194 IAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYIT 253 IA+VHAENG+++AE + LDLGITGPEG +SRPEE+EAEA +R ITIAN+T+CP+Y+ Sbjct: 209 IARVHAENGELVAEGAKEALDLGITGPEGIEISRPEELEAEATHRVITIANRTHCPIYLV 268 Query: 254 KVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTT 313 V S S+ +VIA A+ +G VV E TA G HY+ ++W+ AAA+VT PPL D T Sbjct: 269 NVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNT 328 Query: 314 PDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTG 373 +L SLL+ L + S H F T QKA+GK++FT IP G +G ++RMSVIW++ VV G Sbjct: 329 STYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVIWERGVVGG 388 Query: 374 KMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNI 433 KMDEN+FVAVTS+NAAK+ NLYPRKGRI G+DAD+V+WDP++ KTISA T ++N+ Sbjct: 389 KMDENRFVAVTSSNAAKLLNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNL 448 Query: 434 FEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRG 493 +E M C G PLV IS+G++V E+G EG+G++ P + FPD VYK++ R + ++RG Sbjct: 449 YENMRCHGVPLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDTVYKKLVQREKTLKVRG 508 Query: 494 VPRGLYDGPVCEVSVTP---KTVTPASSAKTSPAKQQAPPVRNLHQSGFSLSGAQIDDNI 550 V R Y G V V V P + TP + T P + +R+LH+S FSLSG+QIDD++ Sbjct: 509 VDRTPYLGDVA-VVVHPGKKEMGTPLADTPTRPVTRHG-GMRDLHESSFSLSGSQIDDHV 566 Query: 551 PRRTTQRIVAPPGGRAN 567 P+R + RI+APPGGR++ Sbjct: 567 PKRASARILAPPGGRSS 583 >4B91-A nrPDB Length = 484 Score = 543 bits (1400), Expect = e-155, Method: Compositional matrix adjust. Identities = 253/474 (53%), Positives = 343/474 (72%) Query: 14 SDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVH 73 S R+LIKGGK+VNDD + AD+Y+E+G+I+Q+G L++PGG K I+A ++VIPGGID Sbjct: 8 SVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTS 67 Query: 74 TRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCC 133 T F T DDF+ GTKAAL GGTTMII HV+P+ TSL+ A+++ R AD K CC Sbjct: 68 THFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVDAYEKCRGLADPKVCC 127 Query: 134 DYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGA 193 DY+LHV I+ W ++ EME LV++ GVNSF ++M +KD + L D ++Y+VL +DIGA Sbjct: 128 DYALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVLHACKDIGA 187 Query: 194 IAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYIT 253 IA+VHAENG+++AE + LDLGITGPEG +SRPEE+EAEA +R ITIAN+T+CP+Y+ Sbjct: 188 IARVHAENGELVAEGAKEALDLGITGPEGIEISRPEELEAEATHRVITIANRTHCPIYLV 247 Query: 254 KVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTT 313 V S S+ +VIA A+ +G VV E TA G HY+ ++W+ AAA+VT PPL D T Sbjct: 248 NVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNT 307 Query: 314 PDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTG 373 +L SLL+ L + S H F T QKA+GK++FT IP G +G ++RMSVIW++ VV G Sbjct: 308 STYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVIWERGVVGG 367 Query: 374 KMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNI 433 KMDEN+FVAVTS+NAAK+ NLYPRKGRI G+DAD+V+WDP++ KTISA T ++N+ Sbjct: 368 KMDENRFVAVTSSNAAKLLNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNL 427 Query: 434 FEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSR 487 +E M C G PLV IS+G++V E+G EG+G++ P + FPD VYK++ R + Sbjct: 428 YENMRCHGVPLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDTVYKKLVQREK 481 >2FTW-A nrPDB Length = 521 Score = 531 bits (1368), Expect = e-151, Method: Compositional matrix adjust. Identities = 253/487 (51%), Positives = 340/487 (69%), Gaps = 5/487 (1%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRF 76 +LIK G +VNDD+ F +D+ +E+G+IK+I +N+ G+K ++A ++++PGGID HT F Sbjct: 10 ILIKNGTVVNDDRYFKSDVLVENGIIKEISKNIEPKEGIKVVDATDKLLLPGGIDTHTHF 69 Query: 77 QMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYS 136 Q+P G S DDF GT+AA+AGGTT IID V+P G SLL A+DQW++WAD K CDYS Sbjct: 70 QLPFMGTVSVDDFDIGTQAAVAGGTTFIIDFVIPTRGQSLLEAYDQWKKWADEKVNCDYS 129 Query: 137 LHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQ 196 LHV I+ W + + EME LVK+ GVNSF +MA+K+ F +TD ++Y + +++GAIAQ Sbjct: 130 LHVAITWWSEQVSREMEILVKERGVNSFKCFMAYKNSFMVTDQEMYHIFKRCKELGAIAQ 189 Query: 197 VHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVM 256 VHAENGD++ E Q+++L++GITGPEGH LSRPE +EAEA NRAI IA+ P+YI V Sbjct: 190 VHAENGDMVFEGQKKMLEMGITGPEGHELSRPEALEAEATNRAIVIADSVCTPVYIVHVQ 249 Query: 257 SKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDF 316 S +A+VI + RK+G VYGEPI A LG DGSH W+ +W AAAFV PP+ PDP T Sbjct: 250 SIGAADVICKHRKEGVRVYGEPIAAGLGVDGSHMWNHDWRHAAAFVMGPPIRPDPRTKGV 309 Query: 317 LNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMD 376 L L+ GDL G+ +CTF QKA+GKD+FT IP G NG E+RMS++W+ V TGK+ Sbjct: 310 LMDYLARGDLDCVGTDNCTFCADQKAMGKDDFTKIPNGVNGVEDRMSIVWENGVNTGKLT 369 Query: 377 ENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEG 436 QFV TS+ A++FN+YPRKGRI VG D D+VIWDP+ KTIS TH+ ++++NIFEG Sbjct: 370 WCQFVRATSSERARIFNIYPRKGRIDVGCDGDIVIWDPNQSKTISKDTHHHAVDFNIFEG 429 Query: 437 MECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFP---DFVYKRIKARSRLAELRG 493 ++ G + I G IV D L +GSGR++PR PF D + +R K R+ L LR Sbjct: 430 IKVTGIAVTTIVAGNIVWSDNKLSCVKGSGRFVPRPPFGPVFDGIEQRDKVRNEL--LRK 487 Query: 494 VPRGLYD 500 V R Y+ Sbjct: 488 VDRKPYE 494 >6AJD-A nrPDB Length = 485 Score = 436 bits (1120), Expect = e-122, Method: Compositional matrix adjust. Identities = 216/470 (45%), Positives = 293/470 (62%), Gaps = 3/470 (0%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRF 76 LLI+G +V ++S+ AD+ +GLI+ IGENL P G ++ + ++PGGID HT Sbjct: 3 LLIRGATVVTHEESYRADVLCANGLIQAIGENLETPSGCDVLDGGGQYLMPGGIDPHTHM 62 Query: 77 QMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYS 136 Q+P G +++DFF GT A LAGGTT IID V+P P SLL AF WR WA KS DY Sbjct: 63 QLPFMGTVASEDFFSGTAAGLAGGTTSIIDFVIPNPRQSLLEAFHTWRGWAQ-KSAADYG 121 Query: 137 LHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQ 196 HV I+ W + EM LV HGVNSF +MA+K+ D + ++GA+ Sbjct: 122 FHVAITWWSDEVAREMGELVAQHGVNSFKHFMAYKNAIMAADDTLVASFERCLELGAVPT 181 Query: 197 VHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVM 256 VHAENG+++ QQ++L G+TGPE H LSRP +VE EA +RAI IA PLY+ + Sbjct: 182 VHAENGELVFHLQQKLLAQGLTGPEAHPLSRPPQVEGEAASRAIRIAETLGTPLYLVHIS 241 Query: 257 SKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDF 316 S+ + + IA AR KG VYGE + L D S Y +WA AA +V SPP P Sbjct: 242 SREALDEIAYARAKGQPVYGEVLAGHLLLDDSVYRHPDWATAAGYVMSPPFRPVEHQEAL 301 Query: 317 LNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMD 376 L S G+L T + HC F QKA+G+D+F+ IP GT G E+RM+++WD V +G++ Sbjct: 302 WRGLQS-GNLHTTATDHCCFCAEQKAMGRDDFSKIPNGTAGIEDRMALLWDAGVNSGRLS 360 Query: 377 ENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEG 436 ++FVA+TSTN AK+FNL+PRKG I VG+DADLV+WDP +T+SA TH+ +++NIFEG Sbjct: 361 MHEFVALTSTNTAKIFNLFPRKGAIRVGADADLVLWDPQGSRTLSAATHHQRVDFNIFEG 420 Query: 437 MECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARS 486 RG P ISQGK++ G L G+GRY+ R +P VY+ + R+ Sbjct: 421 RTVRGIPSHTISQGKLLWAAGDLRAEPGAGRYVERPAYPS-VYEVLGRRA 469 >3DC8-A nrPDB Length = 490 Score = 428 bits (1100), Expect = e-120, Method: Compositional matrix adjust. Identities = 216/483 (44%), Positives = 299/483 (61%), Gaps = 11/483 (2%) Query: 18 LIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQ 77 +IKGG IV D ++ AD+ +E G I +IG NL G +T++A V+PGGID HT + Sbjct: 4 VIKGGTIVTADLTYKADVKVEGGRIVEIGPNL---SGAETLDATGCYVMPGGIDPHTHLE 60 Query: 78 MPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSL 137 MP G S+DDF GT+AALAGGTTM++D +P PG SLL A W +++ CDYS Sbjct: 61 MPFMGTYSSDDFESGTRAALAGGTTMVVDFALPSPGQSLLEALTMWDN-KSTRANCDYSF 119 Query: 138 HVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQV 197 H+ I+ W + + EME +VKD G+N+F +MA+K + D +++ +GA+ V Sbjct: 120 HMAITWWGEQVFNEMETIVKDKGINTFKHFMAYKGALMVDDDEMFSSFQRCAALGALPLV 179 Query: 198 HAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMS 257 HAENGD++A+ Q ++L G +GPE H SRP EVE EA NRAI IA+ CP+YI Sbjct: 180 HAENGDVVAQLQAKLLAEGNSGPEAHAYSRPAEVEGEAANRAIMIADMAGCPVYIVHTSC 239 Query: 258 KSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFL 317 + + E I +AR KG V+GEP+ L D + Y+ K+W AA V SPP + D L Sbjct: 240 EQAHEAIRRARAKGMRVFGEPLIQHLTLDETEYFDKDWDHAARRVMSPPFR-NKLHQDSL 298 Query: 318 NSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDE 377 + L+ G LQV + HC F T QK G +FT IP GT G E+RM ++W V TG++ Sbjct: 299 WAGLASGSLQVVATDHCAFTTEQKRFGVGDFTRIPNGTGGLEDRMPMLWTYGVATGRITM 358 Query: 378 NQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGM 437 N+FVAVTSTN AK+ N+YP+KG I VG+DADLV+WDP KTISAKT S+++YN+FEG Sbjct: 359 NEFVAVTSTNIAKILNIYPKKGAILVGADADLVVWDPKRSKTISAKTQQSAIDYNVFEGK 418 Query: 438 ECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDF-----VYKRIKARSRLAELR 492 G P +++G + +E+GT+ EG G ++ R PFP +K + A R + Sbjct: 419 TVTGLPRFTLTRGVVSIEEGTVKTQEGHGEFVRRDPFPAVSTALSTWKEVTA-PRAVQRS 477 Query: 493 GVP 495 G+P Sbjct: 478 GIP 480 >4TQT-A nrPDB Length = 497 Score = 419 bits (1077), Expect = e-117, Method: Compositional matrix adjust. Identities = 213/456 (46%), Positives = 293/456 (64%), Gaps = 6/456 (1%) Query: 18 LIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQ 77 +IKGG ++ D++F ADI +EDG I IG++L G + I+A V+PGGID HT Q Sbjct: 17 VIKGGTVITADRTFRADILIEDGKIAAIGDSL---EGDEVIDASGCYVMPGGIDPHTHLQ 73 Query: 78 MPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSL 137 MP G S+DDF GT AALAGGTTM++D V+P+ +LL A +W + A K+ DYS Sbjct: 74 MPFMGTYSSDDFDTGTAAALAGGTTMVVDFVLPDSEGNLLDALQEWFQKA-GKARTDYSF 132 Query: 138 HVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQV 197 H+ I+ W++ EM +VK G+N+F +MA+K + D +++ ++GA+ V Sbjct: 133 HMAITGWNERTFNEMAEVVK-RGINTFKHFMAYKGALMVNDDEMFASFQRCAELGAMPLV 191 Query: 198 HAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMS 257 HAENGDI+A+ Q +++ G GPE H SRP EVE EA NRAI IA+Q PLY+ V Sbjct: 192 HAENGDIVAQLQAKLMAEGNDGPEAHAYSRPPEVEGEATNRAIMIADQAGVPLYVVHVSC 251 Query: 258 KSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFL 317 + S E I +AR+KG V+GEP+ L D S Y +++W AA V SPP D D L Sbjct: 252 EQSHEAIRRARQKGMRVFGEPLIQHLTLDESEYHNRDWDYAARRVMSPPFR-DKLNQDSL 310 Query: 318 NSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDE 377 + L+ G LQ + HC F T QK G NFT IP GT G EERM V+W + V TG++ Sbjct: 311 WAGLAAGSLQCVATDHCAFTTEQKRYGIGNFTKIPNGTGGLEERMPVLWTRGVRTGRLTP 370 Query: 378 NQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGM 437 N+FVAVTSTN AK+ N+YP+KG + G+DADLVIWDP++ K ISAKT +SS++YN+FEG Sbjct: 371 NEFVAVTSTNIAKILNIYPQKGAVVPGADADLVIWDPETTKKISAKTQHSSIDYNVFEGF 430 Query: 438 ECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKP 473 E +G P++ +S+G+I + G + G GR+I R+P Sbjct: 431 ELKGLPIMTLSRGRIAFDKGQVTAKPGDGRFIEREP 466 >1YNY-A nrPDB Length = 461 Score = 340 bits (871), Expect = 1e-93, Method: Compositional matrix adjust. Identities = 188/457 (41%), Positives = 271/457 (59%), Gaps = 4/457 (0%) Query: 19 IKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQM 78 I+GG +V ++ AD+ +E + IG L V G + I+A VIPGGID HT M Sbjct: 5 IRGGTVVTAADTYQADVLIEGERVVAIGHQLSV-NGAEEIDATGCYVIPGGIDPHTHLDM 63 Query: 79 PDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLH 138 P G +ADDFF GT+AA GGTT I+D + + G SL +A W E A K+ DY H Sbjct: 64 PFGGTVTADDFFTGTRAAAFGGTTSIVDFCLTKKGESLKSAIATWHEKARGKAVIDYGFH 123 Query: 139 VDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVH 198 + I+E + + EE+E+++ G+ S V+MA+K+ FQ D +++ L +++GA+ QVH Sbjct: 124 LMIAEANDQVLEELESVISSEGITSLKVFMAYKNVFQADDETLFKTLVKAKELGALVQVH 183 Query: 199 AENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMSK 258 AENGD++ ++ L G T P H +RP E E EA RAI + LY+ V Sbjct: 184 AENGDVLDYLTKKALAEGNTDPIYHAYTRPPEAEGEATGRAIALTALAGSQLYVVHVSCA 243 Query: 259 SSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLN 318 S+ + IA+AR+KG VYGE L D S ++ + A +V SPPL + + L Sbjct: 244 SAVQRIAEAREKGWNVYGETCPQYLALDVSIMDQPDF-EGAKYVWSPPLR-EKWNQEVLW 301 Query: 319 SLLSCGDLQVTGSAHCTFN-TAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDE 377 S L G LQ GS HC FN QK +G+ +FT IP G E+R+++++ + V G++ Sbjct: 302 SALKNGILQTVGSDHCPFNFRGQKELGRGDFTKIPNGGPLIEDRLTILYSEGVRQGRISL 361 Query: 378 NQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGM 437 NQFV ++ST AAK+F ++PRKG IAVGSDAD+VI+DP +T+S +TH+ +++YN FEGM Sbjct: 362 NQFVDISSTKAAKLFGMFPRKGTIAVGSDADIVIFDPHVKRTLSVETHHMNVDYNPFEGM 421 Query: 438 ECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPF 474 E G + V+S+G V+ D GSG+YI R F Sbjct: 422 EVYGEVVSVLSRGSFVVRDKQFVGQAGSGQYIKRTTF 458 >1K1D-A nrPDB Length = 460 Score = 322 bits (824), Expect = 4e-88, Method: Compositional matrix adjust. Identities = 181/458 (39%), Positives = 262/458 (57%), Gaps = 4/458 (0%) Query: 18 LIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQ 77 +IK G IV ++ A + ++DG I IG+NL G + I+A V PGGID HT Sbjct: 4 IIKNGTIVTATDTYEAHLLIKDGKIAMIGQNL-EEKGAEVIDAKGCYVFPGGIDPHTHLD 62 Query: 78 MPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSL 137 MP G + DDF GT AA GGTT IID + G L A + W A+ K+ DY Sbjct: 63 MPLGGTVTKDDFESGTIAAAFGGTTTIIDFCLTNKGEPLKKAIETWHNKANGKAVIDYGF 122 Query: 138 HVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQV 197 H+ ISE + EE+ ++++ G+ S V+MA+K+ FQ D +Y L +++GA+ V Sbjct: 123 HLMISEITDDVLEELPKVLEEEGITSLKVFMAYKNVFQADDGTLYCTLLAAKELGALVMV 182 Query: 198 HAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMS 257 HAENGD+I ++ L G T P H L+RP E+E EA RA + LY+ V Sbjct: 183 HAENGDVIDYLTKKALADGNTDPIYHALTRPPELEGEATGRACQLTELAGSQLYVVHVTC 242 Query: 258 KSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFL 317 + E IA+AR KG V+GE L D S+ N+ + A +V SPPL + + L Sbjct: 243 AQAVEKIAEARNKGLDVWGETCPQYLVLDQSYLEKPNF-EGAKYVWSPPLR-EKWHQEVL 300 Query: 318 NSLLSCGDLQVTGSAHCTFN-TAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMD 376 + L G LQ GS C+F+ QK +G+ +FT IP G E+R+S+++ + V G++ Sbjct: 301 WNALKNGQLQTLGSDQCSFDFKGQKELGRGDFTKIPNGGPIIEDRVSILFSEGVKKGRIT 360 Query: 377 ENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEG 436 NQFV + ST AK+F L+P+KG I VGSDADLVI+DP+ + ISA+TH+ +++YN FEG Sbjct: 361 LNQFVDIVSTRIAKLFGLFPKKGTIVVGSDADLVIFDPNIERVISAETHHMAVDYNAFEG 420 Query: 437 MECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPF 474 M+ G P+ V+ +G+ V+ D G G+Y+ R + Sbjct: 421 MKVTGEPVSVLCRGEFVVRDKQFVGKPGYGQYLKRAKY 458 >3SFW-A nrPDB Length = 461 Score = 320 bits (819), Expect = 1e-87, Method: Compositional matrix adjust. Identities = 176/457 (38%), Positives = 266/457 (58%), Gaps = 4/457 (0%) Query: 19 IKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQM 78 I+ G +V ++ AD+ ++ + IG +L + I+A ++PGGID HT M Sbjct: 5 IRNGTVVTASDTYQADVLIDGEKVVAIGSDLQATDA-EVIDATGYYLLPGGIDPHTHLDM 63 Query: 79 PDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLH 138 P G ++D+FF GTKAA GGTT I+D + G SL +A W E A K+ DY H Sbjct: 64 PFGGTVTSDNFFTGTKAAAFGGTTSIVDFCLTSKGESLHSAIATWHEKARGKAVIDYGFH 123 Query: 139 VDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVH 198 + +S+ + + EE+E++V + G+ S V+MA+K+ D +++ L +++GA+ QVH Sbjct: 124 LMVSDANDHVLEELESVVNNEGITSLKVFMAYKNVLMADDETLFKTLIRAKELGALVQVH 183 Query: 199 AENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMSK 258 AENGD++ ++ L G T P H +RP E E EA RAI + + LY+ V Sbjct: 184 AENGDVLDYLTKQALAEGNTDPIYHAYTRPPEAEGEATGRAIALTALADAQLYVVHVSCA 243 Query: 259 SSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLN 318 + IA+AR+KG VYGE L D + ++ + A +V SPPL + D L Sbjct: 244 DAVRRIAEAREKGWNVYGETCPQYLVLDITALEKPDF-EGAKYVWSPPLR-EKWNQDVLW 301 Query: 319 SLLSCGDLQVTGSAHCTFN-TAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDE 377 S L G LQ GS HC FN + QK +G+ +FT IP G E+RM++++ + V GK+ Sbjct: 302 SALKNGILQTVGSDHCPFNFSGQKELGRRDFTKIPNGGPIIEDRMTILFSEGVRKGKISL 361 Query: 378 NQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGM 437 NQFV +TST AK+F ++P+KG IAVGSDAD+V++DP +TIS +TH+ +++YN FEGM Sbjct: 362 NQFVDITSTKVAKLFGMFPQKGTIAVGSDADIVLFDPTVQRTISVETHHMNVDYNPFEGM 421 Query: 438 ECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPF 474 + G + V+S+G V+ + G+GRY+ R F Sbjct: 422 QVHGDVISVLSRGAFVVRNKQFVGHAGAGRYVKRSTF 458 >1GKQ-A nrPDB Length = 458 Score = 315 bits (807), Expect = 3e-86, Method: Compositional matrix adjust. Identities = 168/457 (36%), Positives = 257/457 (56%), Gaps = 3/457 (0%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRF 76 LLIK G+I+ D + ADIY E I +IG+NL P G + I+A + V PG ID H Sbjct: 2 LLIKNGEIITADSRYKADIYAEGETITRIGQNLEAPPGTEVIDATGKYVFPGFIDPHVHI 61 Query: 77 QMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYS 136 +P + D G+KAAL GGTT I+ P L + W+ A+ S CDY+ Sbjct: 62 YLPFMATFAKDTHETGSKAALMGGTTTYIEMCCPSRNDDALEGYQLWKSKAEGNSYCDYT 121 Query: 137 LHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQ 196 H+ +S++ + + ++ +V D G++SF +++++K+ F + D ++Y+ L + +++G I Sbjct: 122 FHMAVSKFDEKTEGQLREIVAD-GISSFKIFLSYKNFFGVDDGEMYQTLRLAKELGVIVT 180 Query: 197 VHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVM 256 H EN +++ QQ++L G TGPE H SRPE VEAE R T T Y+ + Sbjct: 181 AHCENAELVGRLQQKLLSEGKTGPEWHEPSRPEAVEAEGTARFATFLETTGATGYVVHLS 240 Query: 257 SKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDF 316 K + + A+ +G +Y E + D + Y + +A ++ SPPL D Sbjct: 241 CKPALDAAMAAKARGVPIYIESVIPHFLLDKT-YAERGGVEAMKYIMSPPLR-DKRNQKV 298 Query: 317 LNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMD 376 L L+ G + G+ HC F+T QK +GK+ FT IP G E+R+++++ V G++D Sbjct: 299 LWDALAQGFIDTVGTDHCPFDTEQKLLGKEAFTAIPNGIPAIEDRVNLLYTYGVSRGRLD 358 Query: 377 ENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEG 436 ++FV ST AAK+F L+PRKG IAVGSDADLV++DP TIS KT + + +YN FEG Sbjct: 359 IHRFVDAASTKAAKLFGLFPRKGTIAVGSDADLVVYDPQYRGTISVKTQHVNNDYNGFEG 418 Query: 437 MECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKP 473 E G P VV +GK+ + DG +G G+ + R+P Sbjct: 419 FEIDGRPSVVTVRGKVAVRDGQFVGEKGWGKLLRREP 455 >1NFG-A nrPDB Length = 457 Score = 252 bits (643), Expect = 4e-67, Method: Compositional matrix adjust. Identities = 159/459 (34%), Positives = 245/459 (53%), Gaps = 7/459 (1%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRF 76 ++IK G IV D AD+ ++DG I QIG L +TI+A R V PGGIDVHT Sbjct: 3 IIIKNGTIVTADGISRADLGIKDGKITQIGGAL--GPAERTIDAAGRYVFPGGIDVHTHV 60 Query: 77 QMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYS 136 + SAD F T AA GGTT I+D + G SL A +W A KS DY Sbjct: 61 ETVSFNTQSADTFATATVAAACGGTTTIVDFCQQDRGHSLAEAVAKWDGMAGGKSAIDYG 120 Query: 137 LHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQ 196 H+ + + + EE+E L D G+ SF V+MA++ + D + + L G++ Sbjct: 121 YHIIVLDPTDSVIEELEVL-PDLGITSFKVFMAYRGMNMIDDVTLLKTLDKAVKTGSLVM 179 Query: 197 VHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVM 256 VHAENGD + + + G T P H LSRP VEAEA RA+ +A N P+YI V Sbjct: 180 VHAENGDAADYLRDKFVAEGKTAPIYHALSRPPRVEAEATARALALAEIVNAPIYIVHVT 239 Query: 257 SKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDF 316 + S E + +A+ +G E T L ++ + A +V +PP D Sbjct: 240 CEESLEEVMRAKSRGVRALAETCTHYLYLTKEDLERPDF-EGAKYVFTPPARA-KKDHDV 297 Query: 317 LNSLLSCGDLQVTGSAHCTF-NTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKM 375 L + L G + S HC++ K G+++F IP G G EER+ +++ + V G++ Sbjct: 298 LWNALRNGVFETVSSDHCSWLFKGHKDRGRNDFRAIPNGAPGVEERLMMVY-QGVNEGRI 356 Query: 376 DENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFE 435 QFV + +T AKVF ++P+KG IAVGSDAD+V+WDP++ I +++++Y+ +E Sbjct: 357 SLTQFVELVATRPAKVFGMFPQKGTIAVGSDADIVLWDPEAEMVIEQTAMHNAMDYSSYE 416 Query: 436 GMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPF 474 G + +G P V+ +GK+++++G+ G+++ R+ + Sbjct: 417 GHKVKGVPKTVLLRGKVIVDEGSYVGEPTDGKFLKRRKY 455 >2FTY-A nrPDB Length = 559 Score = 207 bits (526), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 154/517 (29%), Positives = 242/517 (46%), Gaps = 64/517 (12%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRF 76 L+IK G I + A+I + +G ++ I ++ G + I+A + PGGID H Sbjct: 5 LIIKNGIICTASDIYAAEIAVNNGKVQLIAASIDPSLGSEVIDAEGAFITPGGIDAHVHV 64 Query: 77 QMPDQGMTSADDFFQ-GTKAALAGGTTMII---DHVVPEPGTSLLAAFDQWR--EWADSK 130 P + + D + T++A+AGGTT ++ V + G S LA + E+++ Sbjct: 65 DEPLKLLGDVVDTMEHATRSAVAGGTTTVVAFSTQDVSKKGPSALAESVKLDVDEYSEQT 124 Query: 131 SCCDYSLHVDISEWHKGIQE-------EMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYE 183 CDY LH+ + + K E +++A D+GV+S ++M + Q++D I Sbjct: 125 LYCDYGLHLILFQIEKPSVEARELLDVQLQAAYNDYGVSSVKMFMTYPG-LQISDYDIMS 183 Query: 184 VLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIA 243 + R G +HAENGD++ + + + G+T H +SRP VE EA NRAIT+A Sbjct: 184 AMYATRKNGFTTMLHAENGDMVKWMIEALEEQGLTDAYYHGVSRPSIVEGEATNRAITLA 243 Query: 244 NQTNCPLYITKVMSKSSAEVIAQARKKGTVVY--------------------GEPITASL 283 + P+ V S +AEVI QA+ KG VY GE + + Sbjct: 244 TTMDTPILFVHVSSPQAAEVIKQAQTKGLKVYAETCPQYALLSDAITRCHHHGEVESYGV 303 Query: 284 GTDGSHYWSKNWAK------AAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFN 337 G D S + + ++ SPP+ P+ T + + G + GS HC++N Sbjct: 304 GIDLSSISESPFTNPDDRFIGSKYICSPPIRPEGTQKSIWKGM-NNGTFTIVGSDHCSYN 362 Query: 338 TAQK--------AVGKDN-----FTLIPEGTNGTEERMSVIWDKAVVTGKMDEN-QFVAV 383 +K A +N F IP G G RM +++D + G + + V + Sbjct: 363 YYEKTSTASKHRAFDPENNKNGEFRYIPNGLPGVCTRMPLLYDYGYLRGNLTSMMKLVEI 422 Query: 384 TSTNAAKVFNLYPRKGRIAVG-SDADLVIWDPDSVKT--------ISAKTHNSSLEYNIF 434 TN AKV+ +YP+KG I G SDADLVIW PD K I+ K + +Y F Sbjct: 423 QCTNPAKVYGMYPQKGSILPGVSDADLVIWYPDDSKKEYNSKPKLITNKLMEHNCDYTPF 482 Query: 435 EGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPR 471 EG+E + P I +GKIV ++G + G+Y+ R Sbjct: 483 EGIEIKNWPRYTIVKGKIVYKEGEILKENADGKYLKR 519 >1GKR-A nrPDB Length = 458 Score = 140 bits (352), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 128/466 (27%), Positives = 220/466 (47%), Gaps = 23/466 (4%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRF 76 +++K ++V+ D ADI ++DG + I + +TI+A + V+PG +D H Sbjct: 4 VIVKNCRLVSSDGITEADILVKDGKVAAISADTSDVEASRTIDAGGKFVMPGVVDEHV-- 61 Query: 77 QMPDQGMTSADDFFQ-GTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDY 135 + D + + F+ +++A GG T II+ + P T+ L AF + ++ A + Sbjct: 62 HIIDMDLKNRYGRFELDSESAAVGGITTIIEMPITFPPTTTLDAFLEKKKQAGQR----- 116 Query: 136 SLHVDISEWHKGIQEEMEALVKDH--GVNSFLVYMA--FKDRFQ-LTDCQIYEVLSVIRD 190 L VD + + G+ + + K H G F MA F ++D +++E+ I Sbjct: 117 -LKVDFALYGGGVPGNLPEIRKMHDAGAVGFKSMMAASVPGMFDAVSDGELFEIFQEIAA 175 Query: 191 IGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPL 250 G++ VHAEN II Q++I G + S+P E EA+ RA+ + + C L Sbjct: 176 CGSVIVVHAENETIIQALQKQIKAAGGKDMAAYEASQPVFQENEAIQRALLLQKEAGCRL 235 Query: 251 YITKVMSKSSAEVIAQARKKGTVVYGE--PITASLGTDGSHYWSKNWAKAAAFVTSPPLS 308 + V + E+I QA+ +G V+ E P ++ TD + + K A V S ++ Sbjct: 236 IVLHVSNPDGVELIHQAQSEGQDVHCESGPQYLNITTDDAERIGP-YMKVAPPVRSAEMN 294 Query: 309 PDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDK 368 L L G + GS H K G + G G E + ++ Sbjct: 295 IR------LWEQLENGLIDTLGSDHGGHPVEDKEPGWKDVWKAGNGALGLETSLPMMLTN 348 Query: 369 AVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSS 428 V G++ + V V AK+F +YP+KG + VGSDADL+I D D + A S Sbjct: 349 GVNKGRLSLERLVEVMCEKPAKLFGIYPQKGTLQVGSDADLLILDLDIDTKVDASQFRSL 408 Query: 429 LEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPF 474 +Y+ F+GM G+P++ + +G +V E G + V +G G+++ R+ + Sbjct: 409 HKYSPFDGMPVTGAPVLTMVRGTVVAEKGEVLVEQGFGQFVTRRNY 454 >3HM7-A nrPDB Length = 448 Score = 130 bits (327), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 127/457 (27%), Positives = 203/457 (44%), Gaps = 42/457 (9%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKT-----IEAHSRMVIPGGID 71 L+I+ +V + ++ AD+ + +G++ I E PG + + I+ + PG +D Sbjct: 8 LIIRSSTVVTETTTYRADVAIRNGIVSAITE----PGSISSDDGPAIDGTGLHLFPGMVD 63 Query: 72 VHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDH-VVPEPGTSLLAAFDQWREWADSK 130 VH F P G T + F G+K+ AGG T D + P T D+ R+ A+ K Sbjct: 64 VHVHFNEP--GRTEWEGFASGSKSLAAGGVTTYFDMPLNSNPPTITREELDKKRQLANEK 121 Query: 131 SCCDYSLHVDISEWHKGIQEEMEAL--VKDHGVNSFLVYMAF--KDRFQLT-DCQIYEVL 185 S DY W + ++ L + D GV F +M+ D FQ + D + + + Sbjct: 122 SLVDYRF------WGGLVPGNIDHLQDLHDGGVIGFKAFMSECGTDDFQFSHDETLLKGM 175 Query: 186 SVIRDIGAIAQVHAENGDI------IAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRA 239 I +G+I VHAE+ ++ IA E+QR+ + + +RP E EAV R Sbjct: 176 KKIAALGSILAVHAESNEMVNALTTIAIEEQRLT------VKDYSEARPIVSELEAVERI 229 Query: 240 ITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAA 299 + A T CP++I V S+ + I QA+ +G V E L + + Sbjct: 230 LRFAQLTCCPIHICHVSSRKVLKRIKQAKGEGVNVSVETCPHYLLFSLDEFAEIGYLAKC 289 Query: 300 AFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTE 359 A PPL D + L++ G++ + S H + Q GK F + G G + Sbjct: 290 A----PPLRERQEVEDLWDGLMA-GEIDLISSDHSP-SLPQMKTGKTIFE-VWGGIAGCQ 342 Query: 360 ERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKT 419 ++V+ + KM Q V + ST AK F LYP+KG I VG++A + D + T Sbjct: 343 NTLAVMLTEGYHKRKMPLTQIVQLLSTEPAKRFGLYPQKGTIQVGAEASFTLIDLNESYT 402 Query: 420 ISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLED 456 ++A + + G RG I QGK V +D Sbjct: 403 LNASDLYYRHPISPYVGQRFRGKVKHTICQGKHVYQD 439 >3E74-A nrPDB Length = 473 Score = 110 bits (275), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 115/428 (26%), Positives = 185/428 (43%), Gaps = 39/428 (9%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVI-PGGIDVHTR 75 L+IK G ++ ++++ DI ++ G I IG++L G K + S +V+ PG +D HT Sbjct: 25 LIIKNGTVILENEARVVDIAVKGGKIAAIGQDL---GDAKEVMDASGLVVSPGMVDAHTH 81 Query: 76 FQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPE-PGTSLLAAFDQWREWADSKSCCD 134 P G + + + GT+AA GG T +I+ + + P T A+ + + A K D Sbjct: 82 ISEP--GRSHWEGYETGTRAAAKGGITTMIEMPLNQLPATVDRASIELKFDAAKGKLTID 139 Query: 135 YSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMA----------FKDRFQLTDCQIYEV 184 + + ++ E++ + GV F ++A F+D + D Q ++ Sbjct: 140 AAQLGGLVSYNIDRLHELDEV----GVVGFKCFVATCGDRGIDNDFRD---VNDWQFFKG 192 Query: 185 LSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIAN 244 + ++G VH EN I E + G +V SRP E EA+ R + +A Sbjct: 193 AQKLGELGQPVLVHCENALICDELGEEAKREGRVTAHDYVASRPVFTEVEAIRRVLYLAK 252 Query: 245 QTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWS-KNWAKAAAFVT 303 C L++ V S E + +AR++G + E D + AK Sbjct: 253 VAGCRLHVCHVSSPEGVEEVTRARQEGQDITCESCPHYFVLDTDQFEEIGTLAKC----- 307 Query: 304 SPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMS 363 SPP+ L + G++ S H KA N G G + M Sbjct: 308 SPPIRDLENQKGMWEKLFN-GEIDCLVSDHSPCPPEMKA---GNIMKAWGGIAGLQSCMD 363 Query: 364 VIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAK 423 V++D+AV M F + +TNAA +F L +KGRIA G DAD V P+S ++ Sbjct: 364 VMFDEAVQKRGMSLPMFGKLMATNAADIFGL-QQKGRIAPGKDADFVFIQPNSSYVLT-- 420 Query: 424 THNSSLEY 431 N LEY Sbjct: 421 --NDDLEY 426 >3GRI-A nrPDB Length = 424 Score = 94.7 bits (234), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 110/445 (24%), Positives = 173/445 (38%), Gaps = 33/445 (7%) Query: 18 LIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQ 77 LIK GK++ + + ADI ++ +IKQI + GV I+A V PG +DVH + Sbjct: 3 LIKNGKVLQNGELQQADILIDGKVIKQIAPAIEPSNGVDIIDAKGHFVSPGFVDVHVHLR 62 Query: 78 MPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSL 137 P G + GTKAA GG T + P + F+ ++ D + Sbjct: 63 EP--GGEYKETIETGTKAAARGGFTTVCPMPNTRPVPDSVEHFEALQKLIDDNAQVRVLP 120 Query: 138 HVDISEWHKGIQ-EEMEALVKDHGVNSFLVYMAFKDR--FQLTDCQIYEVLSVIRDIGAI 194 + I+ G + + ALVK+ AF D T +YE + + Sbjct: 121 YASITTRQLGKELVDFPALVKEGA-------FAFTDDGVGVQTASMMYEGMIEAAKVNKA 173 Query: 195 AQVHAENGDII----AEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPL 250 H E+ +I E +R +LGI G P E+ + R + +A C Sbjct: 174 IVAHCEDNSLIYGGAMHEGKRSKELGIPG-------IPNICESVQIARDVLLAEAAGCHY 226 Query: 251 YITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPD 310 ++ V +K S VI A++ G V E L N A + +PPL Sbjct: 227 HVCHVSTKESVRVIRDAKRAGIHVTAEVTPHHLLLTEDDIPGNN----AIYKMNPPLRST 282 Query: 311 PTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAV 370 L LL G + + H +KA + P G G+E +++ V Sbjct: 283 EDREALLEGLLD-GTIDCIATDHAPHARDEKAQPMEK---APFGIVGSETAFPLLYTHFV 338 Query: 371 VTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLE 430 G Q V + + FNL G + ADL I D DS + I + S + Sbjct: 339 KNGDWTLQQLVDYLTIKPCETFNL--EYGTLKENGYADLTIIDLDSEQEIKGEDFLSKAD 396 Query: 431 YNIFEGMECRGSPLVVISQGKIVLE 455 F G + G+P++ + +G++ E Sbjct: 397 NTPFIGYKVYGNPILTMVEGEVKFE 421 >3MPG-A nrPDB Length = 428 Score = 84.7 bits (208), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 107/447 (23%), Positives = 178/447 (39%), Gaps = 43/447 (9%) Query: 18 LIKGGKIVNDDQSFYA-DIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRF 76 L K G+ +N++ A D+ ++DG I ++ EN I + I+ + +++ PG +DVH Sbjct: 4 LFKNGRYMNEEGKIVATDLLVQDGKIAKVAEN-ITADNAEVIDVNGKLIAPGLVDVHVHL 62 Query: 77 QMPDQGMTSADDFFQGTKAALAGGTTMI--IDHVVPEPGTSLLAAFDQWREWADSKSCCD 134 + P G + GT AA GG T I + + P P D D ++ Sbjct: 63 REP--GGEHKETIETGTLAAAKGGFTTICAMPNTRPVP--------DCREHMEDLQNRIK 112 Query: 135 YSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDR-FQLTDCQIYEVLSVIRDIGA 193 HV++ + + + + D L AF D + D + + A Sbjct: 113 EKAHVNVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASMM--------LAA 164 Query: 194 IAQVHAENGDIIAE-EQQRILDLGITG----PEGHVLSR-PEEVEAEAVNRAITIANQTN 247 + + N ++A E+ +++ G E H L+ P E+ + R I +A + Sbjct: 165 MKRAAKLNMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAAD 224 Query: 248 CPLYITKVMSKSSAEVIAQARKKGTVVYGE--PITASLGTDGSHYWSKNWAKAAAFVTSP 305 C ++ V +K S VI A++ G V E P L D N F +P Sbjct: 225 CHYHVCHVSTKGSVRVIRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPN------FKMNP 278 Query: 306 PLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVI 365 PL + LL G + + + H +KA G + P G G E ++ Sbjct: 279 PLRGKEDHEALIEGLLD-GTIDMIATDHAPHTAEEKAQGIER---APFGITGFETAFPLL 334 Query: 366 WDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTH 425 + V G + Q + + A F L GR+ G AD+ I D + + I T Sbjct: 335 YTNLVKKGIITLEQLIQFLTEKPADTFGL--EAGRLKEGRTADITIIDLEQEEEIDPTTF 392 Query: 426 NSSLEYNIFEGMECRGSPLVVISQGKI 452 S + F G +C+G P++ I GKI Sbjct: 393 LSKGKNTPFAGWKCQGWPVMTIVGGKI 419 >1XRT-A nrPDB Length = 467 Score = 75.5 bits (184), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 100/451 (22%), Positives = 193/451 (42%), Gaps = 41/451 (9%) Query: 16 RLLIKGGKIVNDDQSFYA--DIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVH 73 +L++K G +++ Q+ DI +E+G IK+I +N++VP + I+A +V PG ID+H Sbjct: 48 KLIVKNGYVIDPSQNLEGEFDILVENGKIKKIDKNILVPEA-EIIDAKGLIVCPGFIDIH 106 Query: 74 TRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCC 133 + D G T +D G++ A+AGG T I+ P + + + S C Sbjct: 107 VHLR--DPGQTYKEDIESGSRCAVAGGFTTIVCMPNTNPPIDNTTVVNYILQKSKSVGLC 164 Query: 134 DYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIY-EVLSVIRDIG 192 I++ KG + +K+ G +F D + D + + L + +G Sbjct: 165 RVLPTGTITKGRKGKEIADFYSLKEAGCVAFT-----DDGSPVMDSSVMRKALELASQLG 219 Query: 193 AIAQVHAENGDI---IAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCP 249 H E+ + + E + LG++ SR E E + R +A +T Sbjct: 220 VPIMDHCEDDKLAYGVINEGEVSALLGLS-------SRAPEAEEIQIARDGILAQRTGGH 272 Query: 250 LYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFV-TSPPLS 308 ++I V +K S E+I ++KG IT + + + + + A +PPL Sbjct: 273 VHIQHVSTKLSLEIIEFFKEKGV-----KITCEVNPNHLLFTEREVLNSGANARVNPPLR 327 Query: 309 PDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSV---I 365 + + G + + H T +K + + F + G G + + + Sbjct: 328 KKEDRLALIEGV-KRGIIDCFATDHAPHQTFEKELVE--FAM--PGIIGLQTALPSALEL 382 Query: 366 WDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTH 425 + K +++ K + + + + N A++ + G + +GS AD+ I+DP+ ++ +T+ Sbjct: 383 YRKGIISLK----KLIEMFTINPARIIGV--DLGTLKLGSPADITIFDPNKEWILNEETN 436 Query: 426 NSSLEYNIFEGMECRGSPLVVISQGKIVLED 456 S G +G + I GK+V +D Sbjct: 437 LSKSRNTPLWGKVLKGKVIYTIKDGKMVYKD 467 >2Z00-A nrPDB Length = 426 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 81/403 (20%), Positives = 151/403 (37%), Gaps = 36/403 (8%) Query: 64 MVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQW 123 + PG +D+H + P G +D F G AA+ GG T ++ +P A Sbjct: 46 FLAPGFLDLHAHLREP--GEEVKEDLFSGLLAAVRGGYTDLVSMPNTKPPVDTPEAVRAL 103 Query: 124 REWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYE 183 +E A + ++E +G L+++ G V + R + Sbjct: 104 KEKAKALGLARLHPAAALTEKQEGKTLTPAGLLREAGA----VLLTDDGRTNEDAGVLAA 159 Query: 184 VLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVL---SRPEEVEAEAVNRAI 240 L + +G VHAE+ + + +++ GP +L P E EA + R + Sbjct: 160 GLLMAAPLGLPVAVHAEDAGL---RRNGVMN---DGPLADLLGLPGNPPEAEAARIARDL 213 Query: 241 TIANQT--NCP----LYITKVMSKSSAEVIAQARKKGTVVYGE--PITASLGTDGSHYWS 292 + P L++ + +K E++ +A++ G V E P +L + + Sbjct: 214 EVLRYALRRSPATPRLHVQHLSTKRGLELVREAKRAGLPVTAEATPHHLTLTEEALRTFD 273 Query: 293 KNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIP 352 F +PPL + L LL G L + H A+K + + P Sbjct: 274 P------LFKVAPPLRGEEDREALLEGLLD-GTLDAIATDHAPHTLAEK---EKDLLRAP 323 Query: 353 EGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIW 412 G E +++ + + + V + + +V L P + G++A LV+ Sbjct: 324 FGIPSLEVAFPLLYTELHLKRGFPLQRLVELFTDGPRRVLGLPPL--HLEEGAEASLVLL 381 Query: 413 DPDSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLE 455 P + + S Y+ + G G P++ + G+IV E Sbjct: 382 SPKE-RPVDPSAFASKARYSPWAGWVLGGWPVLTLVAGRIVHE 423 >2GWN-A nrPDB Length = 452 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 91/461 (19%), Positives = 178/461 (38%), Gaps = 44/461 (9%) Query: 16 RLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVP----GGVKTIEAHSRMVIPGGID 71 ++L++ I N+ ++F + ++ I +I E + + IE + PG ID Sbjct: 5 KILLRNALITNEGKTFPGSVMIDGAFISRIIEGELPADDNLSADEVIECSGLRLFPGCID 64 Query: 72 VHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKS 131 F+ P G+T ++AA+AGG T +D P T++ + R+ + Sbjct: 65 DQVHFREP--GLTHKATIASESRAAVAGGVTSFMDMPNTNPPTTMWERLLEKRQIGADTA 122 Query: 132 CCDYSLHVDISEWHKGIQEEMEAL--VKDHGVNSFLVYMAFKDRFQLTDCQIYEVLS-VI 188 +Y + G + ++ + V H V +++ L D + E L + Sbjct: 123 WANYGF------FFGGTNDNIDEIKRVDKHLVPGLKLFLGSSTGNMLVDNK--ETLEKIF 174 Query: 189 RDIGAIAQVHAENGDIIAEEQQRIL-----DLGITGPEGHVLSRPEEVEAEAVNRAITIA 243 + + H E +II ++ DL I H L R EE + A+ +A Sbjct: 175 GECDLLIATHCEKEEIIRANKEHYKAKYGNDLDI---HFHPLIRSEEACYRSSAEAVELA 231 Query: 244 NQTNCPLYITKVMSKSSAEV----IAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAA 299 + N L+I + ++ + I A+K+ IT+ + + ++ + Sbjct: 232 ERMNARLHILHLSTEKELSLFRNDIPTAQKR--------ITSEVCVHHLWFSDTDYGRLG 283 Query: 300 AFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTE 359 + P + + L + + G + + + H A + + + + + G Sbjct: 284 NRIKWNPAIKKESDREALRAAVRNGRIDIIATDH-----APHLLREKEGSCLQAASGGPL 338 Query: 360 ERMSVIWDKAVVT-GKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVK 418 + S++ + G + V+ T+ A +F + ++G I G ADLV+ DP S Sbjct: 339 VQHSLLALLELCNQGIFSIEEIVSKTAHIPATLFAI-EKRGYIRPGYYADLVLVDPSSPH 397 Query: 419 TISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTL 459 T+SA S ++ FEG S G + G L Sbjct: 398 TVSADNILSLCGWSPFEGFTFSHSVAYTFVNGCLAYAKGRL 438 >6HG1-A nrPDB Length = 371 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 29/82 (35%), Positives = 42/82 (51%), Gaps = 2/82 (2%) Query: 66 IPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWRE 125 +PG IDVH + P G T +DF GT AALAGG TM+ P A ++ Sbjct: 6 LPGLIDVHVHLREP--GGTHKEDFASGTAAALAGGITMVCAMPNTRPPIIDAPALALAQK 63 Query: 126 WADSKSCCDYSLHVDISEWHKG 147 A++ + CD++L + S + G Sbjct: 64 LAEAGARCDFALFLGASSENAG 85 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 28/122 (22%), Positives = 55/122 (45%), Gaps = 9/122 (7%) Query: 352 PEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVI 411 P G G E + ++ AV G++ + + N ++F+L P++ + DL Sbjct: 245 PPGFPGLETMLPLLL-TAVSEGRLSLDDLLQRLHHNPRRIFHLPPQEDTYV---EVDL-- 298 Query: 412 WDPDSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPR 471 + TI + S + FEG + +G+ V+ +G++ DG + V G G+ + + Sbjct: 299 ---EHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPPGYGQDVRK 355 Query: 472 KP 473 P Sbjct: 356 WP 357 >5T5I-A nrPDB Length = 569 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 26/82 (31%), Positives = 44/82 (53%), Gaps = 8/82 (9%) Query: 378 NQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGM 437 ++ +T +AKV L KG + VG+DAD+ ++D I+ +T + S EY E Sbjct: 436 SEIAQITRATSAKVLGLSDTKGHLGVGADADIAVYD------INPETVDPSAEYMAIEEA 489 Query: 438 ECRGSPLVVISQGKIVLEDGTL 459 R + V+ G+IV++DG + Sbjct: 490 FSRAA--CVLKDGEIVVKDGEV 509 >4CEX-C nrPDB Length = 570 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 26/77 (33%), Positives = 37/77 (48%), Gaps = 12/77 (15%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGE------------NLIVPGGVKTIEAHSRM 64 LL+ I++ + ADI ++DG I IG+ N+IV + I A ++ Sbjct: 69 LLLTNALILDYTGIYKADIGVKDGYIVGIGKGGNPDIMDGVTPNMIVGTATEVIAAEGKI 128 Query: 65 VIPGGIDVHTRFQMPDQ 81 V GGID H F PDQ Sbjct: 129 VTAGGIDTHVHFINPDQ 145 >2VHL-A nrPDB Length = 396 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 18/33 (54%), Positives = 22/33 (66%) Query: 383 VTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPD 415 +TS NAAK ++ RKG + VG DADLVI D Sbjct: 342 ITSENAAKQLGIFDRKGSVTVGKDADLVIVSSD 374 >3QGK-C nrPDB Length = 568 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 29/109 (26%), Positives = 47/109 (43%), Gaps = 15/109 (13%) Query: 5 GKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGE------------NLIVP 52 G+ N P + L+I I++ + ADI +++G I IG+ +++V Sbjct: 55 GQSNSPDENTLDLVITNALIIDYTGIYKADIGIKNGKIHGIGKAGNKDMQDGVTPHMVVG 114 Query: 53 GGVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGT 101 G + + ++ GGID HT F P Q T+ G GGT Sbjct: 115 VGTEALAGEGMIITAGGIDSHTHFLSPQQFPTA---LANGVTTMFGGGT 160 >3OOQ-A nrPDB Length = 396 Score = 37.4 bits (85), Expect = 0.018, Method: Compositional matrix adjust. Identities = 20/62 (32%), Positives = 31/62 (50%), Gaps = 2/62 (3%) Query: 377 ENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWD--PDSVKTISAKTHNSSLEYNIF 434 E + + + N AK+ L R G I G DADLV+W P +K++ + + +E Sbjct: 329 EEDLLKILTVNPAKILGLEDRIGSIEPGKDADLVVWSGHPFDMKSVVERVYIDGVEVFRR 388 Query: 435 EG 436 EG Sbjct: 389 EG 390 >4WGX-A nrPDB Length = 465 Score = 37.0 bits (84), Expect = 0.023, Method: Compositional matrix adjust. Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 5/82 (6%) Query: 365 IWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKT 424 +W +A+V MD + + N AK + + G I VG D+V+ D D + I T Sbjct: 372 VWMQAMVEKGMDPMAAILAGTANPAKAYRKFDELGSIDVGKLGDVVVLDQDPLADI---T 428 Query: 425 HNSSLEYNIFEGMEC--RGSPL 444 + +L + + EG E G PL Sbjct: 429 NMRTLSHVVKEGREIDFHGLPL 450 >2PUZ-A nrPDB Length = 419 Score = 36.2 bits (82), Expect = 0.038, Method: Compositional matrix adjust. Identities = 18/63 (28%), Positives = 28/63 (44%) Query: 374 KMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNI 433 +M + + T+ NAAK L G + G AD IWD + + + + L I Sbjct: 352 RMTVEECLTATTRNAAKALGLLAETGTLEAGKSADFAIWDIERPAELVYRIGFNPLHARI 411 Query: 434 FEG 436 F+G Sbjct: 412 FKG 414 >1FWC-C nrPDB Length = 567 Score = 34.7 bits (78), Expect = 0.10, Method: Compositional matrix adjust. Identities = 30/98 (30%), Positives = 45/98 (45%), Gaps = 20/98 (20%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGE--------NLIVPGGVKT--IEAHSRMVI 66 L++ IV+ ADI ++DG I IG+ N+ +P G T I A ++V Sbjct: 68 LVLTNALIVDHWGIVKADIGVKDGRIFAIGKAGNPDIQPNVTIPIGAATEVIAAEGKIVT 127 Query: 67 PGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMI 104 GGID H + P Q +A ++G TTM+ Sbjct: 128 AGGIDTHIHWICPQ----------QAEEALVSGVTTMV 155 Score = 28.5 bits (62), Expect = 7.9, Method: Compositional matrix adjust. Identities = 13/36 (36%), Positives = 19/36 (52%) Query: 379 QFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDP 414 +++A + N A + G I VG ADLV+W P Sbjct: 402 RYIAKYTINPALTHGIAHEVGSIEVGKLADLVVWSP 437 >3MKV-A nrPDB Length = 426 Score = 32.7 bits (73), Expect = 0.48, Method: Compositional matrix adjust. Identities = 19/73 (26%), Positives = 35/73 (47%), Gaps = 12/73 (16%) Query: 17 LLIKGGKIVNDD-----QSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGID 71 L + G +++ D Q F +I +EDG I+++ + I I+ + ++PG ID Sbjct: 6 FLFRNGALLDPDHPDLLQGF--EILIEDGFIREVSDKPIKSSNAHVIDVKGKTIMPGLID 63 Query: 72 VHTR-----FQMP 79 +H F +P Sbjct: 64 LHVHVVAIEFNLP 76 >4H9M-A nrPDB Length = 840 Score = 31.6 bits (70), Expect = 0.96, Method: Compositional matrix adjust. Identities = 23/82 (28%), Positives = 35/82 (42%), Gaps = 13/82 (15%) Query: 10 PRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGE------------NLIVPGGVKT 57 P I+ D + I I++ ADI ++DGLI IG+ N+I+ + Sbjct: 333 PAISLDTV-ITNAVIIDYTGIIKADIGIKDGLIASIGKAGNPDIMNGVFSNMIIGANTEV 391 Query: 58 IEAHSRMVIPGGIDVHTRFQMP 79 I +V G ID H + P Sbjct: 392 IAGEGLIVTAGAIDCHVHYICP 413 >3N2C-A nrPDB Length = 423 Score = 31.6 bits (70), Expect = 1.1, Method: Compositional matrix adjust. Identities = 18/53 (33%), Positives = 31/53 (58%), Gaps = 1/53 (1%) Query: 385 STNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTIS-AKTHNSSLEYNIFEG 436 +T AA++ N+ + G IAVG+ ADLV+ D + ++ I + +EY + G Sbjct: 353 TTVAAEIVNMQGQLGVIAVGAIADLVVLDGNPLEDIGVVADEGARVEYVLQRG 405 >1E9Y-B nrPDB Length = 569 Score = 30.0 bits (66), Expect = 2.6, Method: Compositional matrix adjust. Identities = 21/65 (32%), Positives = 28/65 (43%), Gaps = 7/65 (10%) Query: 37 MEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAA 96 M+DG + NL V + + +V GGID H F P Q T+ F G Sbjct: 104 MQDG----VKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTA---FASGVTTM 156 Query: 97 LAGGT 101 + GGT Sbjct: 157 IGGGT 161 >3MWY-W nrPDB Length = 800 Score = 30.0 bits (66), Expect = 3.1, Method: Compositional matrix adjust. Identities = 23/68 (33%), Positives = 38/68 (55%), Gaps = 8/68 (11%) Query: 230 EVEAEAVNRAITIANQTNCPLYITKVMSKSSAE--VIAQARKKGTVVYGEPITASLG-TD 286 + + +A+ RA I + + +Y +++SK + E V+ +ARKK + Y SLG TD Sbjct: 657 QADLQAMARAHRIGQKNHVMVY--RLVSKDTVEEEVLERARKKMILEYA---IISLGVTD 711 Query: 287 GSHYWSKN 294 G+ Y KN Sbjct: 712 GNKYTKKN 719 >2BB0-A nrPDB Length = 421 Score = 30.0 bits (66), Expect = 3.2, Method: Compositional matrix adjust. Identities = 16/53 (30%), Positives = 23/53 (43%) Query: 360 ERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIW 412 E + +I A + KM + + NAA G++ G ADLVIW Sbjct: 333 ENIQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIW 385 >2EX6-A nrPDB Length = 458 Score = 29.6 bits (65), Expect = 3.7, Method: Compositional matrix adjust. Identities = 17/72 (23%), Positives = 33/72 (45%), Gaps = 3/72 (4%) Query: 476 DFVYKRIKAR---SRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVR 532 D + R+ + + +++R +PRG + CE+ V P + + P + + P+ Sbjct: 167 DMAFIRVASYYPVTMFSQVRTLPRGSAEAQYCELDVVPGDLNRFTLTGCLPQRSEPLPLA 226 Query: 533 NLHQSGFSLSGA 544 Q G S +GA Sbjct: 227 FAVQDGASYAGA 238 >4QKD-A nrPDB Length = 200 Score = 28.9 bits (63), Expect = 6.7, Method: Compositional matrix adjust. Identities = 18/69 (26%), Positives = 32/69 (46%), Gaps = 9/69 (13%) Query: 451 KIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRGVPRGLYDGPVCEVSVTP 510 +++LE G+L++ GS RY DF ++ ++ R +PRG +C P Sbjct: 141 ELLLEPGSLYILRGSARY-------DFSHEILRDEESFFGERRIPRGRRISVICR--SLP 191 Query: 511 KTVTPASSA 519 + + P S Sbjct: 192 EGMGPGESG 200 >4Z42-C nrPDB Length = 572 Score = 28.5 bits (62), Expect = 9.2, Method: Compositional matrix adjust. Identities = 14/36 (38%), Positives = 20/36 (55%) Query: 379 QFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDP 414 ++VA + N A + G + VG ADLV+WDP Sbjct: 407 RYVAKITINPAIAQGVSHVIGSVEVGKMADLVLWDP 442 >4V1Y-A nrPDB Length = 494 Score = 28.1 bits (61), Expect = 10.0, Method: Compositional matrix adjust. Identities = 20/64 (31%), Positives = 35/64 (54%), Gaps = 6/64 (9%) Query: 17 LLIKGGKIVNDDQ--SFYAD--IYMEDGLIKQIGENL--IVPGGVKTIEAHSRMVIPGGI 70 L I+ G +V DQ D ++++DG I +G + + P + I+A ++V+PG I Sbjct: 24 LSIQHGTLVTMDQYRRVLGDSWVHVQDGRIVALGVHAESVPPPADRVIDARGKVVLPGFI 83 Query: 71 DVHT 74 + HT Sbjct: 84 NAHT 87 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4CNT-A nrPDB 860 0.0 5NKS-A nrPDB 845 0.0 5YZA-A nrPDB 806 0.0 4B90-A nrPDB 754 0.0 1KCX-A nrPDB 751 0.0 2VR2-A nrPDB 723 0.0 4CNS-A nrPDB 721 0.0 4LCQ-A nrPDB 700 0.0 2FTW-A nrPDB 677 0.0 4B91-A nrPDB 656 0.0 6AJD-A nrPDB 637 0.0 3DC8-A nrPDB 637 0.0 4TQT-A nrPDB 632 0.0 1K1D-A nrPDB 614 e-176 1YNY-A nrPDB 612 e-175 3SFW-A nrPDB 610 e-175 1GKQ-A nrPDB 568 e-162 1NFG-A nrPDB 525 e-149 2FTY-A nrPDB 476 e-135 1GKR-A nrPDB 458 e-129 3E74-A nrPDB 436 e-122 3GRI-A nrPDB 436 e-122 3HM7-A nrPDB 429 e-120 3MPG-A nrPDB 421 e-118 1XRT-A nrPDB 404 e-113 2GWN-A nrPDB 383 e-106 2Z00-A nrPDB 360 e-100 6HG1-A nrPDB 241 6e-64 5T5I-A nrPDB 79 4e-15 Sequences not found previously or not previously below threshold: 3OOQ-A nrPDB 96 3e-20 3GIQ-A nrPDB 87 1e-17 4CEX-C nrPDB 83 3e-16 1RK6-A nrPDB 82 7e-16 1FWC-C nrPDB 81 1e-15 3QGK-C nrPDB 80 2e-15 1E9Y-B nrPDB 74 2e-13 2PUZ-A nrPDB 71 1e-12 4G7E-B nrPDB 68 1e-11 2ICS-A nrPDB 68 1e-11 2VUN-A nrPDB 65 6e-11 4H9M-A nrPDB 64 1e-10 4CQD-A nrPDB 64 1e-10 3HPA-A nrPDB 64 1e-10 4WGX-A nrPDB 64 2e-10 4Z42-C nrPDB 64 2e-10 3IV8-A nrPDB 62 7e-10 4V1Y-A nrPDB 62 8e-10 2AQV-A nrPDB 62 9e-10 4LH8-A nrPDB 60 2e-09 3MKV-A nrPDB 60 4e-09 2OGJ-A nrPDB 59 4e-09 2PLM-A nrPDB 59 6e-09 4R7W-A nrPDB 58 9e-09 3T8L-A nrPDB 58 1e-08 5VGM-A nrPDB 57 2e-08 3N2C-A nrPDB 56 4e-08 2VHL-A nrPDB 55 6e-08 5XGX-A nrPDB 55 7e-08 2BB0-A nrPDB 55 1e-07 6NBO-A nrPDB 54 2e-07 3DUG-A nrPDB 52 5e-07 1O12-A nrPDB 51 1e-06 1YRR-A nrPDB 51 1e-06 4LFY-A nrPDB 47 3e-05 4DYK-A nrPDB 46 5e-05 3IGH-X nrPDB 45 6e-05 3JZE-A nrPDB 45 6e-05 4F0R-A nrPDB 45 7e-05 3MTW-A nrPDB 45 9e-05 3LNP-A nrPDB 44 2e-04 3ICJ-A nrPDB 42 6e-04 2P9B-A nrPDB 42 6e-04 2QS8-A nrPDB 42 8e-04 2OOF-A nrPDB 41 0.001 1R9X-A nrPDB 41 0.001 3GGM-A nrPDB 41 0.001 4WHB-E nrPDB 40 0.003 3MDW-A nrPDB 38 0.012 2OOD-A nrPDB 38 0.015 2PAJ-A nrPDB 37 0.023 2I9U-A nrPDB 37 0.030 4DZH-A nrPDB 37 0.033 3B2Q-A nrPDB 36 0.044 6FV3-A nrPDB 34 0.16 2WJF-A nrPDB 33 0.50 5N6M-A nrPDB 32 0.79 3SLC-A nrPDB 31 1.2 5YDI-A nrPDB 31 1.8 5YDJ-A nrPDB 31 1.8 1ZZM-A nrPDB 30 2.1 5U03-A nrPDB 29 4.6 2VO1-A nrPDB 29 4.6 >4CNT-A nrPDB Length = 570 Score = 860 bits (2222), Expect = 0.0, Method: Composition-based stats. Identities = 437/571 (76%), Positives = 517/571 (90%), Gaps = 2/571 (0%) Query: 1 MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEA 60 MSYQGKKNIPRITSDRLLIKGG+IVNDDQSFYADIYMEDGLIKQIG+NLIVPGGVKTIEA Sbjct: 1 MSYQGKKNIPRITSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEA 60 Query: 61 HSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAF 120 + +MVIPGGIDVHT +QMP +GMT+ DDFFQGTKAALAGGTTMIIDHVVPEP +SL A+ Sbjct: 61 NGKMVIPGGIDVHTHYQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAY 120 Query: 121 DQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQ 180 ++WREWAD KSCCDY+LHVDI+ W+ +++E++ L+KD GVNSF+VYMA+KD +Q+++ + Sbjct: 121 EKWREWADGKSCCDYALHVDITHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTE 180 Query: 181 IYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAI 240 +YE+ + + ++GAIAQVHAENGDIIA+EQ R+L++GITGPEGHVLSRPEE+EAEAV RAI Sbjct: 181 LYEIFTCLGELGAIAQVHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAI 240 Query: 241 TIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAA 300 TIA+QTNCPLY+TKVMSKS+A++I+QARKKG VV+GEPITASLG DG+HYWSKNWAKAAA Sbjct: 241 TIASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAA 300 Query: 301 FVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEE 360 FVTSPPLSPDPTTPD++NSLL+ GDLQ++GSAHCTF+TAQKA+GKDNFT IPEGTNG EE Sbjct: 301 FVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEE 360 Query: 361 RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI 420 RMSVIWDKAV TGKMDENQFVAVTSTNAAK+FNLYPRKGRI+VGSD+DLVIWDPD+VK + Sbjct: 361 RMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKIV 420 Query: 421 SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYK 480 SAK H S+ EYNIFEGME RG+PLVVI QGKI+LEDG LHVT+G+GR+IP PF D+VYK Sbjct: 421 SAKNHQSAAEYNIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYK 480 Query: 481 RIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFS 540 RIKAR ++A+L VPRG+YDGPV +++ TPK TPA SA+ SP + PPVRNLHQSGFS Sbjct: 481 RIKARRKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSARGSPTRPN-PPVRNLHQSGFS 539 Query: 541 LSGAQIDDNIPRRTTQRIVAPPGGRANITSL 571 LSG Q+D+ + R ++RIVAPPGGR+NITSL Sbjct: 540 LSGTQVDEGV-RSASKRIVAPPGGRSNITSL 569 >5NKS-A nrPDB Length = 573 Score = 845 bits (2182), Expect = 0.0, Method: Composition-based stats. Identities = 432/571 (75%), Positives = 504/571 (88%) Query: 1 MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEA 60 MS+QGKK+IPRITSDRLLI+GG+IVNDDQSFYAD+++EDGLIKQIGENLIVPGG+KTI+A Sbjct: 2 MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDA 61 Query: 61 HSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAF 120 H MV+PGG+DVHTR QMP GMT ADDF QGTKAALAGGTTMI+DHV P+ G SLLAA+ Sbjct: 62 HGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAY 121 Query: 121 DQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQ 180 +QWRE ADS +CCDYSLHVDI+ WH+ I+EE+EALVK+ GVNSFLV+MA+KDR Q +D Q Sbjct: 122 EQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQ 181 Query: 181 IYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAI 240 +YE+ S+IRD+GA+AQVHAENGDI+ EEQ+R+L+LGITGPEGHVLS PEEVEAEAV RA+ Sbjct: 182 MYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAV 241 Query: 241 TIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAA 300 TIA Q NCPLY+TKVMSK +A+ IAQA+++G VV+GEPITASLGTDGSHYWSKNWAKAAA Sbjct: 242 TIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAA 301 Query: 301 FVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEE 360 FVTSPP++PDPTT D L LLS GDLQVTGSAHCTF TAQKAVGKDNF LIPEGTNG EE Sbjct: 302 FVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEE 361 Query: 361 RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI 420 RMS++W+K V +GKMDEN+FVAVTSTNAAK+FN YPRKGR+AVGSDADLVIW+P + K I Sbjct: 362 RMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKII 421 Query: 421 SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYK 480 SAKTHN ++EYNIFEG+ECRG+P VVISQG++ LEDG + VT G+GR++PRK FPDFVYK Sbjct: 422 SAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYK 481 Query: 481 RIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFS 540 RIKAR+RLAE+ GVPRGLYDGPV EV V K + A + + P K PPVRNLHQSGFS Sbjct: 482 RIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGKISVPPVRNLHQSGFS 541 Query: 541 LSGAQIDDNIPRRTTQRIVAPPGGRANITSL 571 LSG+Q DD+I RRT Q+I+APPGGR+NITSL Sbjct: 542 LSGSQADDHIARRTAQKIMAPPGGRSNITSL 572 >5YZA-A nrPDB Length = 525 Score = 806 bits (2081), Expect = 0.0, Method: Composition-based stats. Identities = 524/525 (99%), Positives = 524/525 (99%) Query: 1 MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEA 60 MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEA Sbjct: 1 MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEA 60 Query: 61 HSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAF 120 HSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAF Sbjct: 61 HSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAF 120 Query: 121 DQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQ 180 DQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQ Sbjct: 121 DQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQ 180 Query: 181 IYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAI 240 IYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAI Sbjct: 181 IYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAI 240 Query: 241 TIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAA 300 TIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAA Sbjct: 241 TIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAA 300 Query: 301 FVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEE 360 FVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEE Sbjct: 301 FVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEE 360 Query: 361 RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI 420 RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI Sbjct: 361 RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI 420 Query: 421 SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYK 480 SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYK Sbjct: 421 SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYK 480 Query: 481 RIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAK 525 RIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKT PAK Sbjct: 481 RIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTDPAK 525 >4B90-A nrPDB Length = 586 Score = 754 bits (1947), Expect = 0.0, Method: Composition-based stats. Identities = 290/557 (52%), Positives = 396/557 (71%), Gaps = 5/557 (0%) Query: 14 SDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVH 73 S R+LIKGGK+VNDD + AD+Y+E+G+I+Q+G L++PGG K I+A ++VIPGGID Sbjct: 29 SVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTS 88 Query: 74 TRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCC 133 T F T DDF+ GTKAAL GGTTMII HV+P+ TSL+ A+++ R AD K CC Sbjct: 89 THFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVDAYEKCRGLADPKVCC 148 Query: 134 DYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGA 193 DY+LHV I+ W ++ EME LV++ GVNSF ++M +KD + L D ++Y+VL +DIGA Sbjct: 149 DYALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVLHACKDIGA 208 Query: 194 IAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYIT 253 IA+VHAENG+++AE + LDLGITGPEG +SRPEE+EAEA +R ITIAN+T+CP+Y+ Sbjct: 209 IARVHAENGELVAEGAKEALDLGITGPEGIEISRPEELEAEATHRVITIANRTHCPIYLV 268 Query: 254 KVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTT 313 V S S+ +VIA A+ +G VV E TA G HY+ ++W+ AAA+VT PPL D T Sbjct: 269 NVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNT 328 Query: 314 PDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTG 373 +L SLL+ L + S H F T QKA+GK++FT IP G +G ++RMSVIW++ VV G Sbjct: 329 STYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVIWERGVVGG 388 Query: 374 KMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNI 433 KMDEN+FVAVTS+NAAK+ NLYPRKGRI G+DAD+V+WDP++ KTISA T ++N+ Sbjct: 389 KMDENRFVAVTSSNAAKLLNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNL 448 Query: 434 FEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRG 493 +E M C G PLV IS+G++V E+G EG+G++ P + FPD VYK++ R + ++RG Sbjct: 449 YENMRCHGVPLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDTVYKKLVQREKTLKVRG 508 Query: 494 VPRGLYDGPVCEVSVTP---KTVTPASSAKTSPAKQQAPPVRNLHQSGFSLSGAQIDDNI 550 V R Y G V V V P + TP + T P + +R+LH+S FSLSG+QIDD++ Sbjct: 509 VDRTPYLGDVA-VVVHPGKKEMGTPLADTPTRPVTRHG-GMRDLHESSFSLSGSQIDDHV 566 Query: 551 PRRTTQRIVAPPGGRAN 567 P+R + RI+APPGGR++ Sbjct: 567 PKRASARILAPPGGRSS 583 >1KCX-A nrPDB Length = 518 Score = 751 bits (1939), Expect = 0.0, Method: Composition-based stats. Identities = 391/518 (75%), Positives = 461/518 (88%) Query: 8 NIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIP 67 +IP ITSDRLLI+GG+I+NDDQSFYAD+Y+EDGLIKQIGENLIVPGGVKTIEA+ RMVIP Sbjct: 1 SIPHITSDRLLIRGGRIINDDQSFYADVYLEDGLIKQIGENLIVPGGVKTIEANGRMVIP 60 Query: 68 GGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWA 127 GGIDV+T Q P QGMTSADDFFQGTKAALAGGTTMIIDHVVPEPG+SLL +F++W E A Sbjct: 61 GGIDVNTYLQKPSQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGSSLLTSFEKWHEAA 120 Query: 128 DSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSV 187 D+KSCCDYSLHVDI+ W+ G++EE+E LV+D GVNSF VYMA+KD +Q++D Q+YE + Sbjct: 121 DTKSCCDYSLHVDITSWYDGVREELEVLVQDKGVNSFQVYMAYKDLYQMSDSQLYEAFTF 180 Query: 188 IRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTN 247 ++ +GA+ VHAENGD+IA+EQ+RIL++GITGPEGH LSRPEE+EAEAV RAI IA + N Sbjct: 181 LKGLGAVILVHAENGDLIAQEQKRILEMGITGPEGHALSRPEELEAEAVFRAIAIAGRIN 240 Query: 248 CPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPL 307 CP+YITKVMSKS+A++IA ARKKG +V+GEPI ASLGTDG+HYWSKNWAKAAAFVTSPPL Sbjct: 241 CPVYITKVMSKSAADIIALARKKGPLVFGEPIAASLGTDGTHYWSKNWAKAAAFVTSPPL 300 Query: 308 SPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWD 367 SPDPTTPD+L SLL+CGDLQVTGS HC ++TAQKAVGKDNFTLIPEG NG EERM+V+WD Sbjct: 301 SPDPTTPDYLTSLLACGDLQVTGSGHCPYSTAQKAVGKDNFTLIPEGVNGIEERMTVVWD 360 Query: 368 KAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNS 427 KAV TGKMDENQFVAVTSTNAAK+FNLYPRKGRIAVGSDAD+VIWDPD +KTI+AK+H S Sbjct: 361 KAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDADVVIWDPDKMKTITAKSHKS 420 Query: 428 SLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSR 487 ++EYNIFEGMEC GSPLVVISQGKIV EDG + V++G GR+IPRKPFP+ +Y+R++ RS+ Sbjct: 421 TVEYNIFEGMECHGSPLVVISQGKIVFEDGNISVSKGMGRFIPRKPFPEHLYQRVRIRSK 480 Query: 488 LAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAK 525 + L V RG+YDGPV EV TPK PA SAK+SP+K Sbjct: 481 VFGLHSVSRGMYDGPVYEVPATPKHAAPAPSAKSSPSK 518 >2VR2-A nrPDB Length = 541 Score = 723 bits (1867), Expect = 0.0, Method: Composition-based stats. Identities = 311/519 (59%), Positives = 388/519 (74%), Gaps = 9/519 (1%) Query: 16 RLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGV----KTIEAHSRMVIPGGID 71 RLLI+GG++VNDD S AD+ +EDG+++ +G +L+ PGG + ++A ++V+PGGID Sbjct: 28 RLLIRGGRVVNDDFSEVADVLVEDGVVRALGHDLLPPGGAPAGLRVLDAAGKLVLPGGID 87 Query: 72 VHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKS 131 HT Q P G S DDF QGTKAAL+GGTTMIID +P+ G SL+ AF+ WR WAD K Sbjct: 88 THTHMQFPFMGSRSIDDFHQGTKAALSGGTTMIIDFAIPQKGGSLIEAFETWRSWADPKV 147 Query: 132 CCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDI 191 CCDYSLHV ++ W ++EEM+ LV+D GVNSF ++MA+KD + +TD ++YE S ++I Sbjct: 148 CCDYSLHVAVTWWSDQVKEEMKILVQDKGVNSFKMFMAYKDLYMVTDLELYEAFSRCKEI 207 Query: 192 GAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLY 251 GAIAQVHAENGD+IAE +++L LGITGPEGH L RPE VEAEA RAITIA+ NCPLY Sbjct: 208 GAIAQVHAENGDLIAEGAKKMLALGITGPEGHELCRPEAVEAEATLRAITIASAVNCPLY 267 Query: 252 ITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDP 311 I VMSKS+A+VIA AR+ G VVYGEPI ASLGTDG+HYW+K W AA V PPL PDP Sbjct: 268 IVHVMSKSAAKVIADARRDGKVVYGEPIAASLGTDGTHYWNKEWHHAAHHVMGPPLRPDP 327 Query: 312 TTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVV 371 +TPDFL +LL+ DL TG+ +CTFNT QKA+GKD+FT IP G NG E+RMSVIW+K V Sbjct: 328 STPDFLMNLLANDDLTTTGTDNCTFNTCQKALGKDDFTKIPNGVNGVEDRMSVIWEKGVH 387 Query: 372 TGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEY 431 +GKMDEN+FVAVTSTNAAK+FNLYPRKGRIAVGSDAD+VIWDP +TISAKTH+ ++ + Sbjct: 388 SGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIVIWDPKGTRTISAKTHHQAVNF 447 Query: 432 NIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAEL 491 NIFEGM C G PLV IS+GK+V E G VT G G++IPRKPF +++YKRIK R R Sbjct: 448 NIFEGMVCHGVPLVTISRGKVVYEAGVFSVTAGDGKFIPRKPFAEYIYKRIKQRDRTCTP 507 Query: 492 RGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPP 530 V R Y G EV+ VT + T+ ++QA P Sbjct: 508 TPVERAPYKG---EVATLKSRVTKEDA--TAGTRKQAHP 541 >4CNS-A nrPDB Length = 480 Score = 721 bits (1861), Expect = 0.0, Method: Composition-based stats. Identities = 373/479 (77%), Positives = 442/479 (92%) Query: 12 ITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGID 71 +TSDRLLIKGG+IVNDDQSFYADIYMEDGLIKQIG+NLIVPGGVKTIEA+ +MVIPGGID Sbjct: 2 MTSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEANGKMVIPGGID 61 Query: 72 VHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKS 131 VHT +QMP +GMT+ DDFFQGTKAALAGGTTMIIDHVVPEP +SL A+++WREWAD KS Sbjct: 62 VHTHYQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAYEKWREWADGKS 121 Query: 132 CCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDI 191 CCDY+LHVDI+ W+ +++E++ L+KD GVNSF+VYMA+KD +Q+++ ++YE+ + + ++ Sbjct: 122 CCDYALHVDITHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTELYEIFTCLGEL 181 Query: 192 GAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLY 251 GAIAQVHAENGDIIA+EQ R+L++GITGPEGHVLSRPEE+EAEAV RAITIA+QTNCPLY Sbjct: 182 GAIAQVHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAITIASQTNCPLY 241 Query: 252 ITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDP 311 +TKVMSKS+A++I+QARKKG VV+GEPITASLG DG+HYWSKNWAKAAAFVTSPPLSPDP Sbjct: 242 VTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAAFVTSPPLSPDP 301 Query: 312 TTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVV 371 TTPD++NSLL+ GDLQ++GSAHCTF+TAQKA+GKDNFT IPEGTNG EERMSVIWDKAV Sbjct: 302 TTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVA 361 Query: 372 TGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEY 431 TGKMDENQFVAVTSTNAAK+FNLYPRKGRI+VGSD+DLVIWDPD+VK +SAK H S+ EY Sbjct: 362 TGKMDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKIVSAKNHQSAAEY 421 Query: 432 NIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAE 490 NIFEGME RG+PLVVI QGKI+LEDG LHVT+G+GR+IP PF D+VYKRIKAR ++A+ Sbjct: 422 NIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYKRIKARRKMAD 480 >4LCQ-A nrPDB Length = 520 Score = 700 bits (1806), Expect = 0.0, Method: Composition-based stats. Identities = 281/494 (56%), Positives = 373/494 (75%) Query: 16 RLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTR 75 +LIKGGK+VN+D SF++D+++ G I ++G +L VP G + I+A R+VIPGGID HT Sbjct: 26 EILIKGGKVVNEDCSFFSDVHIRGGKIVEVGPDLRVPPGARVIDATDRLVIPGGIDTHTH 85 Query: 76 FQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDY 135 ++ G + DDF GTKAALAGGTTMI+D V+ + G SLL A+D WR+ AD K CCDY Sbjct: 86 MELAFMGTRAVDDFHIGTKAALAGGTTMILDFVMTQKGQSLLEAYDLWRKTADPKVCCDY 145 Query: 136 SLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIA 195 SLHV ++ W +++EM L ++ GVNSF ++MA+K F L D ++Y V S +++GAIA Sbjct: 146 SLHVAVTWWSDEVKDEMRTLAQERGVNSFKMFMAYKGLFMLRDDELYAVFSHCKEVGAIA 205 Query: 196 QVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKV 255 QVHAENGD+IAE +++L LGITGPEGH L RPE VEAEA RAITIA+ NCPLY+ V Sbjct: 206 QVHAENGDLIAEGAKKMLSLGITGPEGHELCRPEAVEAEATQRAITIASAVNCPLYVVHV 265 Query: 256 MSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPD 315 MSKS+A+V+++ARK G VV+GEPI ASLGTDG++YW K+WA AA +V PPL PDP+TP Sbjct: 266 MSKSAADVVSKARKDGRVVFGEPIAASLGTDGTNYWHKDWAHAAQYVMGPPLRPDPSTPG 325 Query: 316 FLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKM 375 +L LL+ DL +TG+ +CTF+ QKA+GKD+FT IP G NG E+RMSVIW+K V +GKM Sbjct: 326 YLMDLLANDDLTLTGTDNCTFSRCQKALGKDDFTRIPNGVNGVEDRMSVIWEKGVHSGKM 385 Query: 376 DENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFE 435 DEN+FVAVTS+NAAK+FN YP+KGRIA SDAD+VIWDP + + ISA+TH+ +++YNIFE Sbjct: 386 DENRFVAVTSSNAAKIFNFYPQKGRIAKDSDADVVIWDPKTTRKISAQTHHQAVDYNIFE 445 Query: 436 GMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRGVP 495 GMEC G P+V +S+G++V E+G L V+ G GR+I R+PF +FVYKRI+ R + + V Sbjct: 446 GMECHGVPVVTVSRGRVVYEEGRLKVSPGQGRFIHRQPFSEFVYKRIRQRDEVGKPAVVI 505 Query: 496 RGLYDGPVCEVSVT 509 R Y G V + + Sbjct: 506 REPYAGEVVALGTS 519 >2FTW-A nrPDB Length = 521 Score = 677 bits (1747), Expect = 0.0, Method: Composition-based stats. Identities = 255/497 (51%), Positives = 343/497 (69%), Gaps = 5/497 (1%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRF 76 +LIK G +VNDD+ F +D+ +E+G+IK+I +N+ G+K ++A ++++PGGID HT F Sbjct: 10 ILIKNGTVVNDDRYFKSDVLVENGIIKEISKNIEPKEGIKVVDATDKLLLPGGIDTHTHF 69 Query: 77 QMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYS 136 Q+P G S DDF GT+AA+AGGTT IID V+P G SLL A+DQW++WAD K CDYS Sbjct: 70 QLPFMGTVSVDDFDIGTQAAVAGGTTFIIDFVIPTRGQSLLEAYDQWKKWADEKVNCDYS 129 Query: 137 LHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQ 196 LHV I+ W + + EME LVK+ GVNSF +MA+K+ F +TD ++Y + +++GAIAQ Sbjct: 130 LHVAITWWSEQVSREMEILVKERGVNSFKCFMAYKNSFMVTDQEMYHIFKRCKELGAIAQ 189 Query: 197 VHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVM 256 VHAENGD++ E Q+++L++GITGPEGH LSRPE +EAEA NRAI IA+ P+YI V Sbjct: 190 VHAENGDMVFEGQKKMLEMGITGPEGHELSRPEALEAEATNRAIVIADSVCTPVYIVHVQ 249 Query: 257 SKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDF 316 S +A+VI + RK+G VYGEPI A LG DGSH W+ +W AAAFV PP+ PDP T Sbjct: 250 SIGAADVICKHRKEGVRVYGEPIAAGLGVDGSHMWNHDWRHAAAFVMGPPIRPDPRTKGV 309 Query: 317 LNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMD 376 L L+ GDL G+ +CTF QKA+GKD+FT IP G NG E+RMS++W+ V TGK+ Sbjct: 310 LMDYLARGDLDCVGTDNCTFCADQKAMGKDDFTKIPNGVNGVEDRMSIVWENGVNTGKLT 369 Query: 377 ENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEG 436 QFV TS+ A++FN+YPRKGRI VG D D+VIWDP+ KTIS TH+ ++++NIFEG Sbjct: 370 WCQFVRATSSERARIFNIYPRKGRIDVGCDGDIVIWDPNQSKTISKDTHHHAVDFNIFEG 429 Query: 437 MECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFP---DFVYKRIKARSRLAELRG 493 ++ G + I G IV D L +GSGR++PR PF D + +R K R+ L LR Sbjct: 430 IKVTGIAVTTIVAGNIVWSDNKLSCVKGSGRFVPRPPFGPVFDGIEQRDKVRNEL--LRK 487 Query: 494 VPRGLYDGPVCEVSVTP 510 V R Y+ + S P Sbjct: 488 VDRKPYEDDNTKNSSKP 504 >4B91-A nrPDB Length = 484 Score = 656 bits (1693), Expect = 0.0, Method: Composition-based stats. Identities = 253/477 (53%), Positives = 344/477 (72%) Query: 14 SDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVH 73 S R+LIKGGK+VNDD + AD+Y+E+G+I+Q+G L++PGG K I+A ++VIPGGID Sbjct: 8 SVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTS 67 Query: 74 TRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCC 133 T F T DDF+ GTKAAL GGTTMII HV+P+ TSL+ A+++ R AD K CC Sbjct: 68 THFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVDAYEKCRGLADPKVCC 127 Query: 134 DYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGA 193 DY+LHV I+ W ++ EME LV++ GVNSF ++M +KD + L D ++Y+VL +DIGA Sbjct: 128 DYALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVLHACKDIGA 187 Query: 194 IAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYIT 253 IA+VHAENG+++AE + LDLGITGPEG +SRPEE+EAEA +R ITIAN+T+CP+Y+ Sbjct: 188 IARVHAENGELVAEGAKEALDLGITGPEGIEISRPEELEAEATHRVITIANRTHCPIYLV 247 Query: 254 KVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTT 313 V S S+ +VIA A+ +G VV E TA G HY+ ++W+ AAA+VT PPL D T Sbjct: 248 NVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNT 307 Query: 314 PDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTG 373 +L SLL+ L + S H F T QKA+GK++FT IP G +G ++RMSVIW++ VV G Sbjct: 308 STYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVIWERGVVGG 367 Query: 374 KMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNI 433 KMDEN+FVAVTS+NAAK+ NLYPRKGRI G+DAD+V+WDP++ KTISA T ++N+ Sbjct: 368 KMDENRFVAVTSSNAAKLLNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNL 427 Query: 434 FEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAE 490 +E M C G PLV IS+G++V E+G EG+G++ P + FPD VYK++ R + + Sbjct: 428 YENMRCHGVPLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDTVYKKLVQREKTLK 484 >6AJD-A nrPDB Length = 485 Score = 637 bits (1643), Expect = 0.0, Method: Composition-based stats. Identities = 217/480 (45%), Positives = 294/480 (61%), Gaps = 3/480 (0%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRF 76 LLI+G +V ++S+ AD+ +GLI+ IGENL P G ++ + ++PGGID HT Sbjct: 3 LLIRGATVVTHEESYRADVLCANGLIQAIGENLETPSGCDVLDGGGQYLMPGGIDPHTHM 62 Query: 77 QMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYS 136 Q+P G +++DFF GT A LAGGTT IID V+P P SLL AF WR WA KS DY Sbjct: 63 QLPFMGTVASEDFFSGTAAGLAGGTTSIIDFVIPNPRQSLLEAFHTWRGWA-QKSAADYG 121 Query: 137 LHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQ 196 HV I+ W + EM LV HGVNSF +MA+K+ D + ++GA+ Sbjct: 122 FHVAITWWSDEVAREMGELVAQHGVNSFKHFMAYKNAIMAADDTLVASFERCLELGAVPT 181 Query: 197 VHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVM 256 VHAENG+++ QQ++L G+TGPE H LSRP +VE EA +RAI IA PLY+ + Sbjct: 182 VHAENGELVFHLQQKLLAQGLTGPEAHPLSRPPQVEGEAASRAIRIAETLGTPLYLVHIS 241 Query: 257 SKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDF 316 S+ + + IA AR KG VYGE + L D S Y +WA AA +V SPP P Sbjct: 242 SREALDEIAYARAKGQPVYGEVLAGHLLLDDSVYRHPDWATAAGYVMSPPFRPVEHQEAL 301 Query: 317 LNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMD 376 L G+L T + HC F QKA+G+D+F+ IP GT G E+RM+++WD V +G++ Sbjct: 302 WRG-LQSGNLHTTATDHCCFCAEQKAMGRDDFSKIPNGTAGIEDRMALLWDAGVNSGRLS 360 Query: 377 ENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEG 436 ++FVA+TSTN AK+FNL+PRKG I VG+DADLV+WDP +T+SA TH+ +++NIFEG Sbjct: 361 MHEFVALTSTNTAKIFNLFPRKGAIRVGADADLVLWDPQGSRTLSAATHHQRVDFNIFEG 420 Query: 437 MECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRGVPR 496 RG P ISQGK++ G L G+GRY+ R +P VY+ + R+ V R Sbjct: 421 RTVRGIPSHTISQGKLLWAAGDLRAEPGAGRYVERPAYPS-VYEVLGRRAERQRPVAVER 479 >3DC8-A nrPDB Length = 490 Score = 637 bits (1642), Expect = 0.0, Method: Composition-based stats. Identities = 216/483 (44%), Positives = 300/483 (62%), Gaps = 11/483 (2%) Query: 18 LIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQ 77 +IKGG IV D ++ AD+ +E G I +IG NL G +T++A V+PGGID HT + Sbjct: 4 VIKGGTIVTADLTYKADVKVEGGRIVEIGPNL---SGAETLDATGCYVMPGGIDPHTHLE 60 Query: 78 MPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSL 137 MP G S+DDF GT+AALAGGTTM++D +P PG SLL A W + +++ CDYS Sbjct: 61 MPFMGTYSSDDFESGTRAALAGGTTMVVDFALPSPGQSLLEALTMWDNKS-TRANCDYSF 119 Query: 138 HVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQV 197 H+ I+ W + + EME +VKD G+N+F +MA+K + D +++ +GA+ V Sbjct: 120 HMAITWWGEQVFNEMETIVKDKGINTFKHFMAYKGALMVDDDEMFSSFQRCAALGALPLV 179 Query: 198 HAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMS 257 HAENGD++A+ Q ++L G +GPE H SRP EVE EA NRAI IA+ CP+YI Sbjct: 180 HAENGDVVAQLQAKLLAEGNSGPEAHAYSRPAEVEGEAANRAIMIADMAGCPVYIVHTSC 239 Query: 258 KSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFL 317 + + E I +AR KG V+GEP+ L D + Y+ K+W AA V SPP + D L Sbjct: 240 EQAHEAIRRARAKGMRVFGEPLIQHLTLDETEYFDKDWDHAARRVMSPPFR-NKLHQDSL 298 Query: 318 NSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDE 377 + L+ G LQV + HC F T QK G +FT IP GT G E+RM ++W V TG++ Sbjct: 299 WAGLASGSLQVVATDHCAFTTEQKRFGVGDFTRIPNGTGGLEDRMPMLWTYGVATGRITM 358 Query: 378 NQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGM 437 N+FVAVTSTN AK+ N+YP+KG I VG+DADLV+WDP KTISAKT S+++YN+FEG Sbjct: 359 NEFVAVTSTNIAKILNIYPKKGAILVGADADLVVWDPKRSKTISAKTQQSAIDYNVFEGK 418 Query: 438 ECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDF-----VYKRIKARSRLAELR 492 G P +++G + +E+GT+ EG G ++ R PFP +K + A R + Sbjct: 419 TVTGLPRFTLTRGVVSIEEGTVKTQEGHGEFVRRDPFPAVSTALSTWKEVTA-PRAVQRS 477 Query: 493 GVP 495 G+P Sbjct: 478 GIP 480 >4TQT-A nrPDB Length = 497 Score = 632 bits (1630), Expect = 0.0, Method: Composition-based stats. Identities = 218/486 (44%), Positives = 302/486 (62%), Gaps = 7/486 (1%) Query: 18 LIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQ 77 +IKGG ++ D++F ADI +EDG I IG++L G + I+A V+PGGID HT Q Sbjct: 17 VIKGGTVITADRTFRADILIEDGKIAAIGDSL---EGDEVIDASGCYVMPGGIDPHTHLQ 73 Query: 78 MPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSL 137 MP G S+DDF GT AALAGGTTM++D V+P+ +LL A +W + A K+ DYS Sbjct: 74 MPFMGTYSSDDFDTGTAAALAGGTTMVVDFVLPDSEGNLLDALQEWFQKA-GKARTDYSF 132 Query: 138 HVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQV 197 H+ I+ W++ EM +VK G+N+F +MA+K + D +++ ++GA+ V Sbjct: 133 HMAITGWNERTFNEMAEVVK-RGINTFKHFMAYKGALMVNDDEMFASFQRCAELGAMPLV 191 Query: 198 HAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMS 257 HAENGDI+A+ Q +++ G GPE H SRP EVE EA NRAI IA+Q PLY+ V Sbjct: 192 HAENGDIVAQLQAKLMAEGNDGPEAHAYSRPPEVEGEATNRAIMIADQAGVPLYVVHVSC 251 Query: 258 KSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFL 317 + S E I +AR+KG V+GEP+ L D S Y +++W AA V SPP D D L Sbjct: 252 EQSHEAIRRARQKGMRVFGEPLIQHLTLDESEYHNRDWDYAARRVMSPPFR-DKLNQDSL 310 Query: 318 NSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDE 377 + L+ G LQ + HC F T QK G NFT IP GT G EERM V+W + V TG++ Sbjct: 311 WAGLAAGSLQCVATDHCAFTTEQKRYGIGNFTKIPNGTGGLEERMPVLWTRGVRTGRLTP 370 Query: 378 NQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGM 437 N+FVAVTSTN AK+ N+YP+KG + G+DADLVIWDP++ K ISAKT +SS++YN+FEG Sbjct: 371 NEFVAVTSTNIAKILNIYPQKGAVVPGADADLVIWDPETTKKISAKTQHSSIDYNVFEGF 430 Query: 438 ECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRGVPRG 497 E +G P++ +S+G+I + G + G GR+I R+P V + + + R V R Sbjct: 431 ELKGLPIMTLSRGRIAFDKGQVTAKPGDGRFIEREPNGA-VNRALSQWKEIVAPRKVERS 489 Query: 498 LYDGPV 503 P+ Sbjct: 490 AEHMPI 495 >1K1D-A nrPDB Length = 460 Score = 614 bits (1584), Expect = e-176, Method: Composition-based stats. Identities = 181/459 (39%), Positives = 262/459 (57%), Gaps = 4/459 (0%) Query: 18 LIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQ 77 +IK G IV ++ A + ++DG I IG+NL G + I+A V PGGID HT Sbjct: 4 IIKNGTIVTATDTYEAHLLIKDGKIAMIGQNLEE-KGAEVIDAKGCYVFPGGIDPHTHLD 62 Query: 78 MPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSL 137 MP G + DDF GT AA GGTT IID + G L A + W A+ K+ DY Sbjct: 63 MPLGGTVTKDDFESGTIAAAFGGTTTIIDFCLTNKGEPLKKAIETWHNKANGKAVIDYGF 122 Query: 138 HVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQV 197 H+ ISE + EE+ ++++ G+ S V+MA+K+ FQ D +Y L +++GA+ V Sbjct: 123 HLMISEITDDVLEELPKVLEEEGITSLKVFMAYKNVFQADDGTLYCTLLAAKELGALVMV 182 Query: 198 HAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMS 257 HAENGD+I ++ L G T P H L+RP E+E EA RA + LY+ V Sbjct: 183 HAENGDVIDYLTKKALADGNTDPIYHALTRPPELEGEATGRACQLTELAGSQLYVVHVTC 242 Query: 258 KSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFL 317 + E IA+AR KG V+GE L D S+ N+ + A +V SPPL + + L Sbjct: 243 AQAVEKIAEARNKGLDVWGETCPQYLVLDQSYLEKPNF-EGAKYVWSPPLR-EKWHQEVL 300 Query: 318 NSLLSCGDLQVTGSAHCTFN-TAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMD 376 + L G LQ GS C+F+ QK +G+ +FT IP G E+R+S+++ + V G++ Sbjct: 301 WNALKNGQLQTLGSDQCSFDFKGQKELGRGDFTKIPNGGPIIEDRVSILFSEGVKKGRIT 360 Query: 377 ENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEG 436 NQFV + ST AK+F L+P+KG I VGSDADLVI+DP+ + ISA+TH+ +++YN FEG Sbjct: 361 LNQFVDIVSTRIAKLFGLFPKKGTIVVGSDADLVIFDPNIERVISAETHHMAVDYNAFEG 420 Query: 437 MECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFP 475 M+ G P+ V+ +G+ V+ D G G+Y+ R + Sbjct: 421 MKVTGEPVSVLCRGEFVVRDKQFVGKPGYGQYLKRAKYG 459 >1YNY-A nrPDB Length = 461 Score = 612 bits (1577), Expect = e-175, Method: Composition-based stats. Identities = 188/457 (41%), Positives = 271/457 (59%), Gaps = 4/457 (0%) Query: 19 IKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQM 78 I+GG +V ++ AD+ +E + IG L V G + I+A VIPGGID HT M Sbjct: 5 IRGGTVVTAADTYQADVLIEGERVVAIGHQLSV-NGAEEIDATGCYVIPGGIDPHTHLDM 63 Query: 79 PDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLH 138 P G +ADDFF GT+AA GGTT I+D + + G SL +A W E A K+ DY H Sbjct: 64 PFGGTVTADDFFTGTRAAAFGGTTSIVDFCLTKKGESLKSAIATWHEKARGKAVIDYGFH 123 Query: 139 VDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVH 198 + I+E + + EE+E+++ G+ S V+MA+K+ FQ D +++ L +++GA+ QVH Sbjct: 124 LMIAEANDQVLEELESVISSEGITSLKVFMAYKNVFQADDETLFKTLVKAKELGALVQVH 183 Query: 199 AENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMSK 258 AENGD++ ++ L G T P H +RP E E EA RAI + LY+ V Sbjct: 184 AENGDVLDYLTKKALAEGNTDPIYHAYTRPPEAEGEATGRAIALTALAGSQLYVVHVSCA 243 Query: 259 SSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLN 318 S+ + IA+AR+KG VYGE L D S ++ + A +V SPPL + + L Sbjct: 244 SAVQRIAEAREKGWNVYGETCPQYLALDVSIMDQPDF-EGAKYVWSPPLR-EKWNQEVLW 301 Query: 319 SLLSCGDLQVTGSAHCTFN-TAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDE 377 S L G LQ GS HC FN QK +G+ +FT IP G E+R+++++ + V G++ Sbjct: 302 SALKNGILQTVGSDHCPFNFRGQKELGRGDFTKIPNGGPLIEDRLTILYSEGVRQGRISL 361 Query: 378 NQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGM 437 NQFV ++ST AAK+F ++PRKG IAVGSDAD+VI+DP +T+S +TH+ +++YN FEGM Sbjct: 362 NQFVDISSTKAAKLFGMFPRKGTIAVGSDADIVIFDPHVKRTLSVETHHMNVDYNPFEGM 421 Query: 438 ECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPF 474 E G + V+S+G V+ D GSG+YI R F Sbjct: 422 EVYGEVVSVLSRGSFVVRDKQFVGQAGSGQYIKRTTF 458 >3SFW-A nrPDB Length = 461 Score = 610 bits (1574), Expect = e-175, Method: Composition-based stats. Identities = 176/458 (38%), Positives = 266/458 (58%), Gaps = 4/458 (0%) Query: 19 IKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQM 78 I+ G +V ++ AD+ ++ + IG +L + I+A ++PGGID HT M Sbjct: 5 IRNGTVVTASDTYQADVLIDGEKVVAIGSDLQATDA-EVIDATGYYLLPGGIDPHTHLDM 63 Query: 79 PDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLH 138 P G ++D+FF GTKAA GGTT I+D + G SL +A W E A K+ DY H Sbjct: 64 PFGGTVTSDNFFTGTKAAAFGGTTSIVDFCLTSKGESLHSAIATWHEKARGKAVIDYGFH 123 Query: 139 VDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVH 198 + +S+ + + EE+E++V + G+ S V+MA+K+ D +++ L +++GA+ QVH Sbjct: 124 LMVSDANDHVLEELESVVNNEGITSLKVFMAYKNVLMADDETLFKTLIRAKELGALVQVH 183 Query: 199 AENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMSK 258 AENGD++ ++ L G T P H +RP E E EA RAI + + LY+ V Sbjct: 184 AENGDVLDYLTKQALAEGNTDPIYHAYTRPPEAEGEATGRAIALTALADAQLYVVHVSCA 243 Query: 259 SSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLN 318 + IA+AR+KG VYGE L D + ++ + A +V SPPL + D L Sbjct: 244 DAVRRIAEAREKGWNVYGETCPQYLVLDITALEKPDF-EGAKYVWSPPLR-EKWNQDVLW 301 Query: 319 SLLSCGDLQVTGSAHCTFN-TAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDE 377 S L G LQ GS HC FN + QK +G+ +FT IP G E+RM++++ + V GK+ Sbjct: 302 SALKNGILQTVGSDHCPFNFSGQKELGRRDFTKIPNGGPIIEDRMTILFSEGVRKGKISL 361 Query: 378 NQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGM 437 NQFV +TST AK+F ++P+KG IAVGSDAD+V++DP +TIS +TH+ +++YN FEGM Sbjct: 362 NQFVDITSTKVAKLFGMFPQKGTIAVGSDADIVLFDPTVQRTISVETHHMNVDYNPFEGM 421 Query: 438 ECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFP 475 + G + V+S+G V+ + G+GRY+ R F Sbjct: 422 QVHGDVISVLSRGAFVVRNKQFVGHAGAGRYVKRSTFA 459 >1GKQ-A nrPDB Length = 458 Score = 568 bits (1464), Expect = e-162, Method: Composition-based stats. Identities = 168/457 (36%), Positives = 257/457 (56%), Gaps = 3/457 (0%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRF 76 LLIK G+I+ D + ADIY E I +IG+NL P G + I+A + V PG ID H Sbjct: 2 LLIKNGEIITADSRYKADIYAEGETITRIGQNLEAPPGTEVIDATGKYVFPGFIDPHVHI 61 Query: 77 QMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYS 136 +P + D G+KAAL GGTT I+ P L + W+ A+ S CDY+ Sbjct: 62 YLPFMATFAKDTHETGSKAALMGGTTTYIEMCCPSRNDDALEGYQLWKSKAEGNSYCDYT 121 Query: 137 LHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQ 196 H+ +S++ + + ++ +V D G++SF +++++K+ F + D ++Y+ L + +++G I Sbjct: 122 FHMAVSKFDEKTEGQLREIVAD-GISSFKIFLSYKNFFGVDDGEMYQTLRLAKELGVIVT 180 Query: 197 VHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVM 256 H EN +++ QQ++L G TGPE H SRPE VEAE R T T Y+ + Sbjct: 181 AHCENAELVGRLQQKLLSEGKTGPEWHEPSRPEAVEAEGTARFATFLETTGATGYVVHLS 240 Query: 257 SKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDF 316 K + + A+ +G +Y E + D + Y + +A ++ SPPL D Sbjct: 241 CKPALDAAMAAKARGVPIYIESVIPHFLLDKT-YAERGGVEAMKYIMSPPLR-DKRNQKV 298 Query: 317 LNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMD 376 L L+ G + G+ HC F+T QK +GK+ FT IP G E+R+++++ V G++D Sbjct: 299 LWDALAQGFIDTVGTDHCPFDTEQKLLGKEAFTAIPNGIPAIEDRVNLLYTYGVSRGRLD 358 Query: 377 ENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEG 436 ++FV ST AAK+F L+PRKG IAVGSDADLV++DP TIS KT + + +YN FEG Sbjct: 359 IHRFVDAASTKAAKLFGLFPRKGTIAVGSDADLVVYDPQYRGTISVKTQHVNNDYNGFEG 418 Query: 437 MECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKP 473 E G P VV +GK+ + DG +G G+ + R+P Sbjct: 419 FEIDGRPSVVTVRGKVAVRDGQFVGEKGWGKLLRREP 455 >1NFG-A nrPDB Length = 457 Score = 525 bits (1352), Expect = e-149, Method: Composition-based stats. Identities = 158/459 (34%), Positives = 246/459 (53%), Gaps = 7/459 (1%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRF 76 ++IK G IV D AD+ ++DG I QIG L +TI+A R V PGGIDVHT Sbjct: 3 IIIKNGTIVTADGISRADLGIKDGKITQIGGALGPAE--RTIDAAGRYVFPGGIDVHTHV 60 Query: 77 QMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYS 136 + SAD F T AA GGTT I+D + G SL A +W A KS DY Sbjct: 61 ETVSFNTQSADTFATATVAAACGGTTTIVDFCQQDRGHSLAEAVAKWDGMAGGKSAIDYG 120 Query: 137 LHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQ 196 H+ + + + EE+E ++ D G+ SF V+MA++ + D + + L G++ Sbjct: 121 YHIIVLDPTDSVIEELE-VLPDLGITSFKVFMAYRGMNMIDDVTLLKTLDKAVKTGSLVM 179 Query: 197 VHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVM 256 VHAENGD + + + G T P H LSRP VEAEA RA+ +A N P+YI V Sbjct: 180 VHAENGDAADYLRDKFVAEGKTAPIYHALSRPPRVEAEATARALALAEIVNAPIYIVHVT 239 Query: 257 SKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDF 316 + S E + +A+ +G E T L ++ + A +V +PP D Sbjct: 240 CEESLEEVMRAKSRGVRALAETCTHYLYLTKEDLERPDF-EGAKYVFTPPARAKKDH-DV 297 Query: 317 LNSLLSCGDLQVTGSAHCTF-NTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKM 375 L + L G + S HC++ K G+++F IP G G EER+ +++ + V G++ Sbjct: 298 LWNALRNGVFETVSSDHCSWLFKGHKDRGRNDFRAIPNGAPGVEERLMMVY-QGVNEGRI 356 Query: 376 DENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFE 435 QFV + +T AKVF ++P+KG IAVGSDAD+V+WDP++ I +++++Y+ +E Sbjct: 357 SLTQFVELVATRPAKVFGMFPQKGTIAVGSDADIVLWDPEAEMVIEQTAMHNAMDYSSYE 416 Query: 436 GMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPF 474 G + +G P V+ +GK+++++G+ G+++ R+ + Sbjct: 417 GHKVKGVPKTVLLRGKVIVDEGSYVGEPTDGKFLKRRKY 455 >2FTY-A nrPDB Length = 559 Score = 476 bits (1226), Expect = e-135, Method: Composition-based stats. Identities = 153/517 (29%), Positives = 239/517 (46%), Gaps = 64/517 (12%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRF 76 L+IK G I + A+I + +G ++ I ++ G + I+A + PGGID H Sbjct: 5 LIIKNGIICTASDIYAAEIAVNNGKVQLIAASIDPSLGSEVIDAEGAFITPGGIDAHVHV 64 Query: 77 QMPDQGMTSA-DDFFQGTKAALAGGTTMIIDH---VVPEPGTSLLAAFDQWR--EWADSK 130 P + + D T++A+AGGTT ++ V + G S LA + E+++ Sbjct: 65 DEPLKLLGDVVDTMEHATRSAVAGGTTTVVAFSTQDVSKKGPSALAESVKLDVDEYSEQT 124 Query: 131 SCCDYSLHVDISEWHKGIQE-------EMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYE 183 CDY LH+ + + K E +++A D+GV+S ++M + Q++D I Sbjct: 125 LYCDYGLHLILFQIEKPSVEARELLDVQLQAAYNDYGVSSVKMFMTYPGL-QISDYDIMS 183 Query: 184 VLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIA 243 + R G +HAENGD++ + + + G+T H +SRP VE EA NRAIT+A Sbjct: 184 AMYATRKNGFTTMLHAENGDMVKWMIEALEEQGLTDAYYHGVSRPSIVEGEATNRAITLA 243 Query: 244 NQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITAS--------------------L 283 + P+ V S +AEVI QA+ KG VY E + Sbjct: 244 TTMDTPILFVHVSSPQAAEVIKQAQTKGLKVYAETCPQYALLSDAITRCHHHGEVESYGV 303 Query: 284 GTDGSHYWSKNWAK------AAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFN 337 G D S + + ++ SPP+ P+ T ++ G + GS HC++N Sbjct: 304 GIDLSSISESPFTNPDDRFIGSKYICSPPIRPEGTQKSIWKG-MNNGTFTIVGSDHCSYN 362 Query: 338 TAQK--------AVGKDN-----FTLIPEGTNGTEERMSVIWDKAVVTGKMD-ENQFVAV 383 +K A +N F IP G G RM +++D + G + + V + Sbjct: 363 YYEKTSTASKHRAFDPENNKNGEFRYIPNGLPGVCTRMPLLYDYGYLRGNLTSMMKLVEI 422 Query: 384 TSTNAAKVFNLYPRKGRIAVG-SDADLVIWDPDSVKT--------ISAKTHNSSLEYNIF 434 TN AKV+ +YP+KG I G SDADLVIW PD K I+ K + +Y F Sbjct: 423 QCTNPAKVYGMYPQKGSILPGVSDADLVIWYPDDSKKEYNSKPKLITNKLMEHNCDYTPF 482 Query: 435 EGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPR 471 EG+E + P I +GKIV ++G + G+Y+ R Sbjct: 483 EGIEIKNWPRYTIVKGKIVYKEGEILKENADGKYLKR 519 >1GKR-A nrPDB Length = 458 Score = 458 bits (1179), Expect = e-129, Method: Composition-based stats. Identities = 124/465 (26%), Positives = 213/465 (45%), Gaps = 21/465 (4%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRF 76 +++K ++V+ D ADI ++DG + I + +TI+A + V+PG +D H Sbjct: 4 VIVKNCRLVSSDGITEADILVKDGKVAAISADTSDVEASRTIDAGGKFVMPGVVDEHVHI 63 Query: 77 QMPDQGMTSADD-FFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDY 135 D + + F +++A GG T II+ + P T+ L AF + ++ A + D+ Sbjct: 64 --IDMDLKNRYGRFELDSESAAVGGITTIIEMPITFPPTTTLDAFLEKKKQAGQRLKVDF 121 Query: 136 SLHVDISEWHKGIQEEMEAL--VKDHGVNSFLVYMA--FKDRFQ-LTDCQIYEVLSVIRD 190 +L + G+ + + + D G F MA F ++D +++E+ I Sbjct: 122 AL------YGGGVPGNLPEIRKMHDAGAVGFKSMMAASVPGMFDAVSDGELFEIFQEIAA 175 Query: 191 IGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPL 250 G++ VHAEN II Q++I G + S+P E EA+ RA+ + + C L Sbjct: 176 CGSVIVVHAENETIIQALQKQIKAAGGKDMAAYEASQPVFQENEAIQRALLLQKEAGCRL 235 Query: 251 YITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWS-KNWAKAAAFVTSPPLSP 309 + V + E+I QA+ +G V+ E L + K A V S ++ Sbjct: 236 IVLHVSNPDGVELIHQAQSEGQDVHCESGPQYLNITTDDAERIGPYMKVAPPVRSAEMNI 295 Query: 310 DPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKA 369 L L G + GS H K G + G G E + ++ Sbjct: 296 R------LWEQLENGLIDTLGSDHGGHPVEDKEPGWKDVWKAGNGALGLETSLPMMLTNG 349 Query: 370 VVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSL 429 V G++ + V V AK+F +YP+KG + VGSDADL+I D D + A S Sbjct: 350 VNKGRLSLERLVEVMCEKPAKLFGIYPQKGTLQVGSDADLLILDLDIDTKVDASQFRSLH 409 Query: 430 EYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPF 474 +Y+ F+GM G+P++ + +G +V E G + V +G G+++ R+ + Sbjct: 410 KYSPFDGMPVTGAPVLTMVRGTVVAEKGEVLVEQGFGQFVTRRNY 454 >3E74-A nrPDB Length = 473 Score = 436 bits (1120), Expect = e-122, Method: Composition-based stats. Identities = 112/464 (24%), Positives = 190/464 (40%), Gaps = 25/464 (5%) Query: 14 SDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVH 73 S L+IK G ++ ++++ DI ++ G I IG++L + ++A +V PG +D H Sbjct: 22 SFDLIIKNGTVILENEARVVDIAVKGGKIAAIGQDL--GDAKEVMDASGLVVSPGMVDAH 79 Query: 74 TRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPE-PGTSLLAAFDQWREWADSKSC 132 T P G + + + GT+AA GG T +I+ + + P T A+ + + A K Sbjct: 80 THISEP--GRSHWEGYETGTRAAAKGGITTMIEMPLNQLPATVDRASIELKFDAAKGKLT 137 Query: 133 CDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMA-------FKDRFQLTDCQIYEVL 185 D + + ++ E++ + GV F ++A D + D Q ++ Sbjct: 138 IDAAQLGGLVSYNIDRLHELDEV----GVVGFKCFVATCGDRGIDNDFRDVNDWQFFKGA 193 Query: 186 SVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQ 245 + ++G VH EN I E + G +V SRP E EA+ R + +A Sbjct: 194 QKLGELGQPVLVHCENALICDELGEEAKREGRVTAHDYVASRPVFTEVEAIRRVLYLAKV 253 Query: 246 TNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSP 305 C L++ V S E + +AR++G + E D + SP Sbjct: 254 AGCRLHVCHVSSPEGVEEVTRARQEGQDITCESCPHYFVLDTDQFEEIGTLA----KCSP 309 Query: 306 PLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVI 365 P+ L G++ S H KA N G G + M V+ Sbjct: 310 PIRDLENQKGMWEKLF-NGEIDCLVSDHSPCPPEMKA---GNIMKAWGGIAGLQSCMDVM 365 Query: 366 WDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTH 425 +D+AV M F + +TNAA +F L +KGRIA G DAD V P+S ++ Sbjct: 366 FDEAVQKRGMSLPMFGKLMATNAADIFGL-QQKGRIAPGKDADFVFIQPNSSYVLTNDDL 424 Query: 426 NSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYI 469 + + + G I +G ++ + G++I Sbjct: 425 EYRHKVSPYVGRTIGARITKTILRGDVIYDIEQGFPVAPKGQFI 468 >3GRI-A nrPDB Length = 424 Score = 436 bits (1120), Expect = e-122, Method: Composition-based stats. Identities = 109/443 (24%), Positives = 173/443 (39%), Gaps = 29/443 (6%) Query: 18 LIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQ 77 LIK GK++ + + ADI ++ +IKQI + GV I+A V PG +DVH + Sbjct: 3 LIKNGKVLQNGELQQADILIDGKVIKQIAPAIEPSNGVDIIDAKGHFVSPGFVDVHVHLR 62 Query: 78 MPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSL 137 P G + GTKAA GG T + P + F+ ++ D + Sbjct: 63 EP--GGEYKETIETGTKAAARGGFTTVCPMPNTRPVPDSVEHFEALQKLIDDNAQVRVLP 120 Query: 138 HVDISEWHKGIQ-EEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQ 196 + I+ G + + ALVK+ G +F T +YE + + Sbjct: 121 YASITTRQLGKELVDFPALVKE-GAFAF----TDDGVGVQTASMMYEGMIEAAKVNKAIV 175 Query: 197 VHAENGDII----AEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYI 252 H E+ +I E +R +LGI G P E+ + R + +A C ++ Sbjct: 176 AHCEDNSLIYGGAMHEGKRSKELGIPG-------IPNICESVQIARDVLLAEAAGCHYHV 228 Query: 253 TKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPT 312 V +K S VI A++ G V E L N A + +PPL Sbjct: 229 CHVSTKESVRVIRDAKRAGIHVTAEVTPHHLLLTEDDIPGNN----AIYKMNPPLRSTED 284 Query: 313 TPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVT 372 L LL G + + H +KA + P G G+E +++ V Sbjct: 285 REALLEGLLD-GTIDCIATDHAPHARDEKAQPME---KAPFGIVGSETAFPLLYTHFVKN 340 Query: 373 GKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYN 432 G Q V + + FNL G + ADL I D DS + I + S + Sbjct: 341 GDWTLQQLVDYLTIKPCETFNL--EYGTLKENGYADLTIIDLDSEQEIKGEDFLSKADNT 398 Query: 433 IFEGMECRGSPLVVISQGKIVLE 455 F G + G+P++ + +G++ E Sbjct: 399 PFIGYKVYGNPILTMVEGEVKFE 421 >3HM7-A nrPDB Length = 448 Score = 429 bits (1102), Expect = e-120, Method: Composition-based stats. Identities = 121/449 (26%), Positives = 195/449 (43%), Gaps = 22/449 (4%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGE-NLIVPGGVKTIEAHSRMVIPGGIDVHTR 75 L+I+ +V + ++ AD+ + +G++ I E I I+ + PG +DVH Sbjct: 8 LIIRSSTVVTETTTYRADVAIRNGIVSAITEPGSISSDDGPAIDGTGLHLFPGMVDVHVH 67 Query: 76 FQMPDQGMTSADDFFQGTKAALAGGTTMIIDHV-VPEPGTSLLAAFDQWREWADSKSCCD 134 F P G T + F G+K+ AGG T D P T D+ R+ A+ KS D Sbjct: 68 FNEP--GRTEWEGFASGSKSLAAGGVTTYFDMPLNSNPPTITREELDKKRQLANEKSLVD 125 Query: 135 YSLHVDISEWHKGIQEEMEAL--VKDHGVNSFLVYMAF--KDRFQLT-DCQIYEVLSVIR 189 Y W + ++ L + D GV F +M+ D FQ + D + + + I Sbjct: 126 YRF------WGGLVPGNIDHLQDLHDGGVIGFKAFMSECGTDDFQFSHDETLLKGMKKIA 179 Query: 190 DIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCP 249 +G+I VHAE+ +++ ++ + + +RP E EAV R + A T CP Sbjct: 180 ALGSILAVHAESNEMVNALTTIAIEEQRLTVKDYSEARPIVSELEAVERILRFAQLTCCP 239 Query: 250 LYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSP 309 ++I V S+ + I QA+ +G V E L + + A PPL Sbjct: 240 IHICHVSSRKVLKRIKQAKGEGVNVSVETCPHYLLFSLDEFAEIGYLAKCA----PPLRE 295 Query: 310 DPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKA 369 D + L++ G++ + S H + Q GK F + G G + ++V+ + Sbjct: 296 RQEVEDLWDGLMA-GEIDLISSDHSP-SLPQMKTGKTIFE-VWGGIAGCQNTLAVMLTEG 352 Query: 370 VVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSL 429 KM Q V + ST AK F LYP+KG I VG++A + D + T++A Sbjct: 353 YHKRKMPLTQIVQLLSTEPAKRFGLYPQKGTIQVGAEASFTLIDLNESYTLNASDLYYRH 412 Query: 430 EYNIFEGMECRGSPLVVISQGKIVLEDGT 458 + + G RG I QGK V +D Sbjct: 413 PISPYVGQRFRGKVKHTICQGKHVYQDHE 441 >3MPG-A nrPDB Length = 428 Score = 421 bits (1083), Expect = e-118, Method: Composition-based stats. Identities = 102/449 (22%), Positives = 172/449 (38%), Gaps = 29/449 (6%) Query: 18 LIKGGKIVNDDQSFYA-DIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRF 76 L K G+ +N++ A D+ ++DG I ++ EN+ + I+ + +++ PG +DVH Sbjct: 4 LFKNGRYMNEEGKIVATDLLVQDGKIAKVAENI-TADNAEVIDVNGKLIAPGLVDVHVHL 62 Query: 77 QMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYS 136 + P G + GT AA GG T I P + + K+ + Sbjct: 63 REP--GGEHKETIETGTLAAAKGGFTTICAMPNTRPVPDCREHMEDLQNRIKEKAHVNVL 120 Query: 137 LHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIY-EVLSVIRDIGAIA 195 + I+ G + +K+ G +F D + D + + + Sbjct: 121 PYGAITVRQAGSEMTDFETLKELGAFAFT-----DDGVGVQDASMMLAAMKRAAKLNMAV 175 Query: 196 QVHAENGDIIAEEQQRILDLGITGPEGHVLSR-PEEVEAEAVNRAITIANQTNCPLYITK 254 H E +I + + G E H L+ P E+ + R I +A +C ++ Sbjct: 176 VAHCEENTLIN---KGCVHEGKF-SEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCH 231 Query: 255 VMSKSSAEVIAQARKKGTVVYGEPITAS--LGTDGSHYWSKNWAKAAAFVTSPPLSPDPT 312 V +K S VI A++ G V E L D N F +PPL Sbjct: 232 VSTKGSVRVIRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPN------FKMNPPLRGKED 285 Query: 313 TPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVT 372 + LL G + + + H +KA G + P G G E +++ V Sbjct: 286 HEALIEGLLD-GTIDMIATDHAPHTAEEKAQGIE---RAPFGITGFETAFPLLYTNLVKK 341 Query: 373 GKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYN 432 G + Q + + A F L GR+ G AD+ I D + + I T S + Sbjct: 342 GIITLEQLIQFLTEKPADTFGL--EAGRLKEGRTADITIIDLEQEEEIDPTTFLSKGKNT 399 Query: 433 IFEGMECRGSPLVVISQGKIVLEDGTLHV 461 F G +C+G P++ I GKI + + V Sbjct: 400 PFAGWKCQGWPVMTIVGGKIAWQKESALV 428 >1XRT-A nrPDB Length = 467 Score = 404 bits (1037), Expect = e-113, Method: Composition-based stats. Identities = 98/448 (21%), Positives = 186/448 (41%), Gaps = 35/448 (7%) Query: 16 RLLIKGGKIVNDDQSFYA--DIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVH 73 +L++K G +++ Q+ DI +E+G IK+I +N++VP + I+A +V PG ID+H Sbjct: 48 KLIVKNGYVIDPSQNLEGEFDILVENGKIKKIDKNILVPEA-EIIDAKGLIVCPGFIDIH 106 Query: 74 TRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCC 133 + P G T +D G++ A+AGG T I+ P + + + S C Sbjct: 107 VHLRDP--GQTYKEDIESGSRCAVAGGFTTIVCMPNTNPPIDNTTVVNYILQKSKSVGLC 164 Query: 134 DYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIY-EVLSVIRDIG 192 I++ KG + +K+ G +F D + D + + L + +G Sbjct: 165 RVLPTGTITKGRKGKEIADFYSLKEAGCVAFT-----DDGSPVMDSSVMRKALELASQLG 219 Query: 193 AIAQVHAENGDI---IAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCP 249 H E+ + + E + LG++ SR E E + R +A +T Sbjct: 220 VPIMDHCEDDKLAYGVINEGEVSALLGLS-------SRAPEAEEIQIARDGILAQRTGGH 272 Query: 250 LYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFV-TSPPLS 308 ++I V +K S E+I ++KG + E L + + + A +PPL Sbjct: 273 VHIQHVSTKLSLEIIEFFKEKGVKITCEVNPNHLL-----FTEREVLNSGANARVNPPLR 327 Query: 309 PDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDK 368 + + G + + H T +K + + G G + + + Sbjct: 328 KKEDRLALIEG-VKRGIIDCFATDHAPHQTFEKELVE----FAMPGIIGLQTALPS-ALE 381 Query: 369 AVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSS 428 G + + + + + N A++ + G + +GS AD+ I+DP+ ++ +T+ S Sbjct: 382 LYRKGIISLKKLIEMFTINPARIIGV--DLGTLKLGSPADITIFDPNKEWILNEETNLSK 439 Query: 429 LEYNIFEGMECRGSPLVVISQGKIVLED 456 G +G + I GK+V +D Sbjct: 440 SRNTPLWGKVLKGKVIYTIKDGKMVYKD 467 >2GWN-A nrPDB Length = 452 Score = 383 bits (983), Expect = e-106, Method: Composition-based stats. Identities = 90/458 (19%), Positives = 175/458 (38%), Gaps = 38/458 (8%) Query: 16 RLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPG----GVKTIEAHSRMVIPGGID 71 ++L++ I N+ ++F + ++ I +I E + + IE + PG ID Sbjct: 5 KILLRNALITNEGKTFPGSVMIDGAFISRIIEGELPADDNLSADEVIECSGLRLFPGCID 64 Query: 72 VHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKS 131 F+ P G+T ++AA+AGG T +D P T++ + R+ + Sbjct: 65 DQVHFREP--GLTHKATIASESRAAVAGGVTSFMDMPNTNPPTTMWERLLEKRQIGADTA 122 Query: 132 CCDYSLHVDISEWHKGIQEEMEAL--VKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVI- 188 +Y + G + ++ + V H V +++ L D + E L I Sbjct: 123 WANYGF------FFGGTNDNIDEIKRVDKHLVPGLKLFLGSSTGNMLVDNK--ETLEKIF 174 Query: 189 RDIGAIAQVHAENGDIIAEEQQRILDL-GIT-GPEGHVLSRPEEVEAEAVNRAITIANQT 246 + + H E +II ++ G H L R EE + A+ +A + Sbjct: 175 GECDLLIATHCEKEEIIRANKEHYKAKYGNDLDIHFHPLIRSEEACYRSSAEAVELAERM 234 Query: 247 NCPLYITKVMSKSSAEV----IAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFV 302 N L+I + ++ + I A+K+ IT+ + + ++ + + Sbjct: 235 NARLHILHLSTEKELSLFRNDIPTAQKR--------ITSEVCVHHLWFSDTDYGRLGNRI 286 Query: 303 TSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERM 362 P + + L + + G + + + H +K + + + G + Sbjct: 287 KWNPAIKKESDREALRAAVRNGRIDIIATDHAPHLLREKE-----GSCLQAASGGPLVQH 341 Query: 363 SVIWDKAVVT-GKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTIS 421 S++ + G + V+ T+ A +F + ++G I G ADLV+ DP S T+S Sbjct: 342 SLLALLELCNQGIFSIEEIVSKTAHIPATLFAI-EKRGYIRPGYYADLVLVDPSSPHTVS 400 Query: 422 AKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTL 459 A S ++ FEG S G + G L Sbjct: 401 ADNILSLCGWSPFEGFTFSHSVAYTFVNGCLAYAKGRL 438 >2Z00-A nrPDB Length = 426 Score = 360 bits (924), Expect = e-100, Method: Composition-based stats. Identities = 85/446 (19%), Positives = 167/446 (37%), Gaps = 31/446 (6%) Query: 17 LLIKGGKIVND-DQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTR 75 +LI+ ++V+ + AD+ + +G I +L + ++ + PG +D+H Sbjct: 2 ILIRNVRLVDARGERGPADVLIGEGRIL----SLEGGEAKQVVDGTGCFLAPGFLDLHAH 57 Query: 76 FQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDY 135 + P G +D F G AA+ GG T ++ +P A +E A + Sbjct: 58 LREP--GEEVKEDLFSGLLAAVRGGYTDLVSMPNTKPPVDTPEAVRALKEKAKALGLARL 115 Query: 136 SLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIA 195 ++E +G L+++ G V + R + L + +G Sbjct: 116 HPAAALTEKQEGKTLTPAGLLREAGA----VLLTDDGRTNEDAGVLAAGLLMAAPLGLPV 171 Query: 196 QVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQ------TNCP 249 VHAE+ + + +++ G + P E EA + R + + Sbjct: 172 AVHAEDAGL---RRNGVMNDGPLADLLGLPGNPPEAEAARIARDLEVLRYALRRSPATPR 228 Query: 250 LYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSP 309 L++ + +K E++ +A++ G V E L + + F +PPL Sbjct: 229 LHVQHLSTKRGLELVREAKRAGLPVTAEATPHHLTLTEEALRTFD----PLFKVAPPLRG 284 Query: 310 DPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKA 369 + L LL G L + H A+K + + P G E +++ + Sbjct: 285 EEDREALLEGLLD-GTLDAIATDHAPHTLAEK---EKDLLRAPFGIPSLEVAFPLLYTEL 340 Query: 370 VVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSL 429 + + V + + +V L P + G++A LV+ P + + S Sbjct: 341 HLKRGFPLQRLVELFTDGPRRVLGLPPL--HLEEGAEASLVLLSPK-ERPVDPSAFASKA 397 Query: 430 EYNIFEGMECRGSPLVVISQGKIVLE 455 Y+ + G G P++ + G+IV E Sbjct: 398 RYSPWAGWVLGGWPVLTLVAGRIVHE 423 >6HG1-A nrPDB Length = 371 Score = 241 bits (615), Expect = 6e-64, Method: Composition-based stats. Identities = 82/412 (19%), Positives = 138/412 (33%), Gaps = 64/412 (15%) Query: 66 IPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWRE 125 +PG IDVH + P G T +DF GT AALAGG TM+ P A ++ Sbjct: 6 LPGLIDVHVHLREP--GGTHKEDFASGTAAALAGGITMVCAMPNTRPPIIDAPALALAQK 63 Query: 126 WADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRF----QLTDCQI 181 A++ + CD++L + S + G + +Y+A + Q Sbjct: 64 LAEAGARCDFALFLGASSENAGTLGTVA-----GSAAGLKLYLANATTNSSHGVTSVVQW 118 Query: 182 YEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAIT 241 E HAE + A + Sbjct: 119 MEHFE-TWPSHLPIVAHAEEQTVAA--------------------------------VLM 145 Query: 242 IANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAF 301 +A T ++I V K +I A+ +G V E L K Sbjct: 146 VAQLTQRSVHICHVARKEEILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVR 205 Query: 302 VTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEER 361 P L ++ + S H +K + P G G E Sbjct: 206 ---PELGSRQDVEALWENM---AVIDCFASDHAPHTLEEKC-----GSRPPPGFPGLETM 254 Query: 362 MSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTIS 421 + ++ AV G++ + + N ++F+L P++ V D + TI Sbjct: 255 LPLLLT-AVSEGRLSLDDLLQRLHHNPRRIFHLPPQEDT--------YVEVDLEHEWTIP 305 Query: 422 AKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKP 473 + S + FEG + +G+ V+ +G++ DG + V G G+ + + P Sbjct: 306 SHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPPGYGQDVRKWP 357 >3OOQ-A nrPDB Length = 396 Score = 96.3 bits (238), Expect = 3e-20, Method: Composition-based stats. Identities = 73/433 (16%), Positives = 132/433 (30%), Gaps = 104/433 (24%) Query: 14 SDRLLIKGGKIVN-DDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDV 72 S ++L K + + F D+ + +G ++++GEN+ P + ++ + + PG +D Sbjct: 4 SVKILFKNATVFPITSRPFKGDVLVSNGKVEKVGENIEDPDA-EIVDLTGKFLFPGFVDA 62 Query: 73 HTR--FQMPDQGMTSADDFFQ-------------------GTKAALAGGTTMIIDHVVPE 111 H+ G +D + ALAGG T ++ Sbjct: 63 HSHIGLFEEGVGYYYSDGNEATDPVTPHVKALDGFNPQDPAIERALAGGVTSVMIVPGSA 122 Query: 112 PGTSLLAAFDQWREWADSKSCCD--YSLHVDISEWHKGIQEE----MEALVKDHGV---- 161 + ++R + L + E K + E + GV Sbjct: 123 NPVGGQGSVIKFRSIIVEECIVKDPAGLKMAFGENPKRVYGERKQTPSTRMGTAGVIRDY 182 Query: 162 -NSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGP 220 YM K+ Q + E + E G+++ +++I Sbjct: 183 FTKVKNYMKKKELAQKEGKEFTETDLKM-----------EVGEMV--LRKKIPAR----M 225 Query: 221 EGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPIT 280 H A+ + AI IA + L I E ++ V E Sbjct: 226 HAH--------RADDILTAIRIAEEFGFNLVIEH-----GTEAYKISK-----VLAEKKI 267 Query: 281 ASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQ 340 + + +K L T + + LL G L H Sbjct: 268 PVVVGPLLTFRTK-------------LELKDLTMETIAKLLKDGVLIALMCDH------- 307 Query: 341 KAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGR 400 +IP + ++ + E + + + N AK+ L R G Sbjct: 308 --------PVIPLEFATVQAATAMRY-------GAKEEDLLKILTVNPAKILGLEDRIGS 352 Query: 401 IAVGSDADLVIWD 413 I G DADLV+W Sbjct: 353 IEPGKDADLVVWS 365 >3GIQ-A nrPDB Length = 480 Score = 87.4 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 82/457 (17%), Positives = 148/457 (32%), Gaps = 91/457 (19%) Query: 19 IKGGKIVNDDQS--FYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTR- 75 I GG I++ + AD+ + DG I IGE L +A ++V PG IDVH Sbjct: 11 ITGGWIIDGTGAPRRRADLGVRDGRIAAIGE-LGAHPARHAWDASGKIVAPGFIDVHGHD 69 Query: 76 ----FQMPDQGMTSADDFFQ-----------------GTKAALA--GGTTMIIDHV---- 108 + PD ++ T AALA G T + D Sbjct: 70 DLMFVEKPDLRWKTSQGITTVVVGNCGVSAAPAPLPGNTAAALALLGETPLFADVPAYFA 129 Query: 109 --VPEPGTSLLAAFDQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLV 166 + +AA A+ + + + ++M + G F Sbjct: 130 ALDAQRPMINVAALV---GHANLRLAAMRDPQAAPTAAEQQAMQDMLQAALEAGAVGFST 186 Query: 167 YMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLS 226 +A++ ++ ++ +A+V AE + H+ + Sbjct: 187 GLAYQPG----------AVAQAAELEGLARVAAERRRL---------------HTSHIRN 221 Query: 227 RPEEVEAEAVNRAITIANQTNCPLYITKVMS---------KSSAEVIAQARKKGTVVYGE 277 + VEA AV + I T C ++ +++ I +AR++G V + Sbjct: 222 EADGVEA-AVEEVLAIGRGTGCATVVSHHKCMMPQNWGRSRATLANIDRAREQGVEVALD 280 Query: 278 PITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAH-CTF 336 I G+ + +T P+ + + G + T + Sbjct: 281 -IYPYPGSSTILIPERAETIDDIRITWSTPHPECSGEYLADIAARWGCDKTTAARRLAPA 339 Query: 337 NTAQKAVGKDNFTLI---------PEGTNGTEERMSVIWDKAVV--------TGKMDENQ 379 A+ +D I +G +W M Q Sbjct: 340 GAIYFAMDEDEVKRIFQHPCCMVGSDGLPNDARPHPRLWGSFTRVLGRYVREARLMTLEQ 399 Query: 380 FVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDS 416 VA + A+VF + +G + G+ AD+V++DPD+ Sbjct: 400 AVARMTALPARVFG-FAERGVLQPGAWADVVVFDPDT 435 >4CEX-C nrPDB Length = 570 Score = 83.2 bits (204), Expect = 3e-16, Method: Composition-based stats. Identities = 79/418 (18%), Positives = 133/418 (31%), Gaps = 64/418 (15%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIG------------ENLIVPGGVKTIEAHSRM 64 LL+ I++ + ADI ++DG I IG N+IV + I A ++ Sbjct: 69 LLLTNALILDYTGIYKADIGVKDGYIVGIGKGGNPDIMDGVTPNMIVGTATEVIAAEGKI 128 Query: 65 VIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQ-- 122 V GGID H F PDQ ALA G T + P A Sbjct: 129 VTAGGIDTHVHFINPDQ-----------VDVALANGITTLFG-GGTGPAEGSKATTVTPG 176 Query: 123 -WREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQI 181 W KS ++V I G D G ++ + + T I Sbjct: 177 PWNIEKMLKSTEGLPINVGILGKGHGSSIAPIMEQIDAGAAGLKIH----EDWGATPASI 232 Query: 182 YEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDL-GITGPEGHVLSRPEEVEAEAVNRAI 240 L+V + +H++ + + + + G H VE A Sbjct: 233 DRSLTVADEADVQVAIHSDTLNEAGFLEDTLRAINGRVIHSFH-------VEGAGGGHAP 285 Query: 241 TIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASL-GTDGSHYWSKNWAKAA 299 I P V+ + I L H+ +N + Sbjct: 286 DIMAMAGHP------------NVLPSSTNPTRPFTVNTIDEHLDMLMVCHHLKQNIPEDV 333 Query: 300 AFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGK--DNFTLIPEGTNG 357 AF S P T + L G + + + A+G+ + + + Sbjct: 334 AFADS---RIRPETIAAEDILHDLGIISMMSTD-------ALAMGRAGEMVLRTWQTADK 383 Query: 358 TEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPD 415 +++ + ++ + ++V+ + N A + G I G ADLV+W+P Sbjct: 384 MKKQRGPLAEEKNGSDNFRLKRYVSKYTINPAIAQGIAHEVGSIEEGKFADLVLWEPK 441 >1RK6-A nrPDB Length = 496 Score = 82.0 bits (201), Expect = 7e-16, Method: Composition-based stats. Identities = 92/532 (17%), Positives = 156/532 (29%), Gaps = 114/532 (21%) Query: 5 GKKNIPRITSDRLLIKGGKIVNDDQS--FYADIYMEDGLIKQIGENLIVPGGVKTIEAHS 62 G + P T ++ GG +++ + AD+ + I +G +L + I+ Sbjct: 11 GSMSQPDATPFDYILSGGTVIDGTNAPGRLADVGVRGDRIAAVG-DLSASSARRRIDVAG 69 Query: 63 RMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIID-----------HVVPE 111 ++V PG ID HT + + D + ++ G T ++ H P Sbjct: 70 KVVSPGFIDSHTHDD--NYLLKHRDMTPKISQ-----GVTTVVTGNCGISLAPLAHANPP 122 Query: 112 PGTSLLAA---------FDQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVN 162 LL D + + + V S + M L ++ + Sbjct: 123 APLDLLDEGGSFRFARFSDYLEALRAAPPAVNAACMVGHSTLRAAV---MPDLRREATAD 179 Query: 163 SFLVYMAFKDRFQLTDCQIYEVLSVIRDIGA--IAQVHAENGDIIAEEQQRILDLGITGP 220 A L D + I GA HA +II + I G+ Sbjct: 180 EIQAMQA------LADDALASGAIGIS-TGAFYPPAAHASTEEIIEVCRPLITHGGVYAT 232 Query: 221 EGHVLSRPEEVEAEAVNRAITIANQTNCPLYITK--VM-------SKSSAEVIAQARKKG 271 E R I + + P+ I+ VM SK + +I A Sbjct: 233 HMRDEGEHIVQALEETFR---IGRELDVPVVISHHKVMGKLNFGRSKETLALIEAA-MAS 288 Query: 272 TVVYGEPITASLGTDGS--------------------HYWSKNWAKAAA------FVTSP 305 V + G+ ++ + AA + P Sbjct: 289 QDVSLDAYPYVAGSTMLKQDRVLLAGRTLITWCKPYPELSGRDLEEIAAERGKSKYDVVP 348 Query: 306 PLSPDPT-----TPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEE 360 L P + +L+ G + GS + F Sbjct: 349 ELQPAGAIYFMMDEPDVQRILAFGP-TMIGSDGLPHDERPHPRLWGTFPR---------- 397 Query: 361 RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI 420 V+ + G V + A F L R G++ G ADLV++DP +V Sbjct: 398 ---VLGHYSRDLGLFPLETAVWKMTGLTAAKFGLAER-GQVQPGYYADLVVFDPATV--- 450 Query: 421 SAKTHNSSLEYNIFEGMECRGSPLV-VISQGKIVLEDGTLHVTEGSGRYIPR 471 + FE R + + V G V ED + +GR + R Sbjct: 451 --------ADSATFEHPTERAAGIHSVYVNGAAVWEDQSFTGQH-AGRVLNR 493 >1FWC-C nrPDB Length = 567 Score = 81.3 bits (199), Expect = 1e-15, Method: Composition-based stats. Identities = 77/414 (18%), Positives = 135/414 (32%), Gaps = 60/414 (14%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIG--------ENLIVPGGV--KTIEAHSRMVI 66 L++ IV+ ADI ++DG I IG N+ +P G + I A ++V Sbjct: 68 LVLTNALIVDHWGIVKADIGVKDGRIFAIGKAGNPDIQPNVTIPIGAATEVIAAEGKIVT 127 Query: 67 PGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREW 126 GGID H + P Q AL G T ++ + + Sbjct: 128 AGGIDTHIHWICPQQAEE-----------ALVSGVTTMVGGGTGPAAGTHATTCTPGPWY 176 Query: 127 ADSKSCCDYSLHVDISEWHKGIQEEMEALVKD--HGVNSFLVYMAFKDRFQLTDCQIYEV 184 SL V+I KG + +AL + GV ++ + + T I Sbjct: 177 ISRMLQAADSLPVNIGLLGKGNVSQPDALREQVAAGVIGLKIH----EDWGATPAAIDCA 232 Query: 185 LSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPE-GHVLSRPEEVEAEAVNRAITIA 243 L+V ++ +H++ + + + +G H E A I Sbjct: 233 LTVADEMDIQVALHSDTLNESGFVEDTLAAIGGRTIHTFH-------TEGAGGGHAPDII 285 Query: 244 NQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASL-GTDGSHYWSKNWAKAAAFV 302 I + + I L +H+ + A+ AF Sbjct: 286 -TACAHPNILPSSTNPTL-----------PYTLNTIDEHLDMLMVAHHLDPDIAEDVAFA 333 Query: 303 TSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGK--DNFTLIPEGTNGTEE 360 S D L+ L G +T S +A+G+ + + + + Sbjct: 334 ESRIRRETIAAEDVLHDL---GAFSLTSSD-------SQAMGRVGEVILRTWQVAHRMKV 383 Query: 361 RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDP 414 + + ++ +++A + N A + G I VG ADLV+W P Sbjct: 384 QRGALAEETGDNDNFRVKRYIAKYTINPALTHGIAHEVGSIEVGKLADLVVWSP 437 >3QGK-C nrPDB Length = 568 Score = 80.1 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 81/526 (15%), Positives = 162/526 (30%), Gaps = 104/526 (19%) Query: 5 GKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGEN------------LIVP 52 G+ N P + L+I I++ + ADI +++G I IG+ ++V Sbjct: 55 GQSNSPDENTLDLVITNALIIDYTGIYKADIGIKNGKIHGIGKAGNKDMQDGVTPHMVVG 114 Query: 53 GGVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMII-----DH 107 G + + ++ GGID HT F P Q T ALA G T + Sbjct: 115 VGTEALAGEGMIITAGGIDSHTHFLSPQQFPT-----------ALANGVTTMFGGGTGPV 163 Query: 108 VVPEPGTSLLAAFDQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVY 167 T ++ R ++ +Y ++V + G F ++ Sbjct: 164 DGTNATTITPGVWNLHRML---RAAEEYGMNVGLLGKGNSSSRAQLVEQVKAGAIGFKLH 220 Query: 168 MAFKDRFQLTDCQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSR 227 + + T I LSV + +H + + + + + + Sbjct: 221 ----EDWGTTPSAIDHCLSVADEYDVQVCIHTDTVNEAGYVDDTLRAMNGRAIHAYHI-- 274 Query: 228 PEEVEAEAVNRAITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASL-GTD 286 E IT+A + N ++ + + L Sbjct: 275 -EGAGGGHSPDVITMAGEVN---------------ILPSSTTPTIPYTINTVAEHLDMLM 318 Query: 287 GSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGK- 345 H+ K + F S P + ++L G + +T S +A+G+ Sbjct: 319 TCHHLDKRIREDLQFSQS---RIRPGSIAAEDTLHDMGVIAMTSSD-------SQAMGRA 368 Query: 346 -DNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVG 404 + + + ++ + ++ ++++ + N A + G + G Sbjct: 369 GEVIPRTWQTADKNKKEFGRLTEEKGDNDNFRIKRYISKYTINPAITHGVSEYIGSVEEG 428 Query: 405 SDADLVIWDPDSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLED-------- 456 ADLV+W+P F G++ P ++I G +V + Sbjct: 429 KIADLVVWNP------------------AFFGVK----PKIIIKGGMVVFSEMGDSNASV 466 Query: 457 --------GTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRGV 494 + G ++ F V + +L R V Sbjct: 467 PTPQPVYYREMFGHHGKAKFDTSITFVSKVAYENGIKEKLGLERKV 512 >5T5I-A nrPDB Length = 569 Score = 79.3 bits (194), Expect = 4e-15, Method: Composition-based stats. Identities = 30/118 (25%), Positives = 54/118 (45%), Gaps = 8/118 (6%) Query: 367 DKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHN 426 A + + ++ +T +AKV L KG + VG+DAD+ ++D I+ +T + Sbjct: 425 TVATIDREYTFSEIAQITRATSAKVLGLSDTKGHLGVGADADIAVYD------INPETVD 478 Query: 427 SSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKA 484 S EY E R + V+ G+IV++DG + + Y + +Y + A Sbjct: 479 PSAEYMAIEEAFSRAA--CVLKDGEIVVKDGEVVASPHGRTYWVDTQVDESIYSEVLA 534 Score = 60.1 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 19/62 (30%), Positives = 31/62 (50%), Gaps = 8/62 (12%) Query: 18 LIKGGKI---VNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHT 74 +IK G + +N DI ++DG I + V K I+A ++V+PGG+D H+ Sbjct: 4 IIKNGFVYCPLNGVDGEKMDICVKDGKIVE-----SVSDSAKVIDASGKIVMPGGVDPHS 58 Query: 75 RF 76 Sbjct: 59 HI 60 >1E9Y-B nrPDB Length = 569 Score = 73.9 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 77/426 (18%), Positives = 133/426 (31%), Gaps = 60/426 (14%) Query: 6 KKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQ------------IGENLIVPG 53 + N P L+I IV+ + ADI ++DG I + NL V Sbjct: 57 QSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGP 116 Query: 54 GVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPG 113 + + +V GGID H F P Q T A +G TTMI P G Sbjct: 117 ATEALAGEGLIVTAGGIDTHIHFISPQQIPT----------AFASGVTTMIGGGTGPADG 166 Query: 114 TSLLAAFDQWREWA-DSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKD 172 T+ R ++ +YS+++ + A + G F ++ + Sbjct: 167 TNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNASNDASLADQIEAGAIGFKIH----E 222 Query: 173 RFQLTDCQIYEVLSVIRDIGAIAQVHAE--NGDIIAEEQQRILDLGITGPEGHVLSRPEE 230 + T I L V +H + N E+ + G T H Sbjct: 223 DWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIA-GRTMHTFH------- 274 Query: 231 VEAEAVNRAITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHY 290 E A I I + + + + D S Sbjct: 275 TEGAGGGHAPDIIKVAGEH-NILPASTNPTIPFTVNTEAEHMDMLM-VCHHK---DKSIK 329 Query: 291 WSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGK--DNF 348 +A + P T ++L G +T S +A+G+ + Sbjct: 330 EDVQFADS---------RIRPQTIAAEDTLHDMGAFSITSSD-------SQAMGRVGEVI 373 Query: 349 TLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDAD 408 T + + ++ + ++ ++++ + N A + G + VG AD Sbjct: 374 TRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVAD 433 Query: 409 LVIWDP 414 LV+W P Sbjct: 434 LVLWSP 439 >2PUZ-A nrPDB Length = 419 Score = 71.2 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 71/449 (15%), Positives = 121/449 (26%), Gaps = 114/449 (25%) Query: 33 ADIYMEDGLIKQIGENLIVPG----GVKTIEAHSRMVIPGGIDVHTR----------FQM 78 A I + +G I G +P +T + R + P ID HT F+M Sbjct: 40 AVIAVRNGRIAFAGPESDLPDDLSTADETTDCGGRWITPALIDCHTHLVFGGNRAMEFEM 99 Query: 79 PDQGMTSADDFFQGTKAALAGGTTM------------IIDHVVPEPGTSLLAAFDQWREW 126 G T + A GG ++ +P T L Sbjct: 100 RLNGATYEE------IAKAGGGIVSSVRDTRALSDEVLVAQALPRLDTLLSEGVSTIEIK 153 Query: 127 ADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLS 186 + Y L ++ + +E L V S+L A ++ + Sbjct: 154 SG------YGLDIETELKMLRVARRLETLRPVRIVTSYLAAHATPADYKGRNADYIT--- 204 Query: 187 VIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEA-----VNRAIT 241 D++ ++ G+ E A ++R Sbjct: 205 ----------------DVVLPGLEKAHAEGLADAVD------GFCEGIAFSVKEIDRVFA 242 Query: 242 IANQTNCP--LYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKA- 298 A Q P L+ ++ + AE+ A +L D Y + AKA Sbjct: 243 AAQQRGLPVKLHAEQLSNLGGAELAAS-------------YNALSADHLEYLDETGAKAL 289 Query: 299 AAFVTSPPLSP------DPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIP 352 A T L P + +L G + Sbjct: 290 AKAGTVAVLLPGAFYALREKQLPPVQALRDAGAEIALATDCNP----------------- 332 Query: 353 EGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIW 412 + + + +M + + T+ NAAK L G + G AD IW Sbjct: 333 --GTSPLTSLLLTMNMGATLFRMTVEECLTATTRNAAKALGLLAETGTLEAGKSADFAIW 390 Query: 413 DPDSVKTISAKTHNSSLEYNIFEGMECRG 441 D + + + +N +G Sbjct: 391 DIERPAEL-----VYRIGFNPLHARIFKG 414 >4G7E-B nrPDB Length = 840 Score = 67.8 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 75/468 (16%), Positives = 133/468 (28%), Gaps = 90/468 (19%) Query: 10 PRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIG------------ENLIVPGGVKT 57 P S +I I++ ADI ++DGLI IG +N+ + Sbjct: 332 PPALSLDTVITNAVIIDYSGIIKADIGIKDGLIHSIGKSGNPDVMDGVFQNMTTGVNTEV 391 Query: 58 IEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMII----DHVVPEPG 113 I +V G ID H + P A+ G T ++ Sbjct: 392 IAGEGLIVTAGAIDCHVHYICPQLVYE-----------AVTSGITTLVGGGTGPTAGTRA 440 Query: 114 TSLLAAFDQWREWADSKSCCDYSLHVDISEWHK-GIQEEMEALVKDHGVNSFLVYMAFKD 172 T+ A Q + +S D L+ + +E+ ++K G ++ + Sbjct: 441 TTCTPAPIQMKLM--LQSTDDLPLNFGFTGKGNCAKPDELHEIIK-AGAMGLKLH----E 493 Query: 173 RFQLTDCQIYEVLSVIRDIGAIAQVHAEN-GDIIAEEQQRILDLGITGPEGHVLSRPEEV 231 + T I L++ +H + + E G T H Sbjct: 494 DWGTTPAAIDSCLTIAEQYDIQVNIHTDTLNESGFVEHTIAAFKGRTIHTYHS------- 546 Query: 232 EAEAVNRAITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASL-GTDGSHY 290 E A I V+ + + I + H+ Sbjct: 547 EGAGGGHAPDIIKVCG------------EKNVLPSSTNPTRPLTSNTIDEHVDMLMVCHH 594 Query: 291 WSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGK--DNF 348 N A+ AF S T + L G + + S +A+G+ + Sbjct: 595 LDANIAEDVAFSAS---RIREATIAAEDILHDMGAISIISSD-------SQAMGRIGEVI 644 Query: 349 TLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDAD 408 + + + + + ++VA + N A G + VG AD Sbjct: 645 SRTWQTADKMKSARGPLQPGEEANDNFRIKRYVAKYTINPAIANGFSQYVGSVEVGKLAD 704 Query: 409 LVIWDPDSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLED 456 LV+W P P +VI G++ + Sbjct: 705 LVMWKPS----------------------FFGAKPEMVIKGGEVAYAN 730 >2ICS-A nrPDB Length = 379 Score = 67.8 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 82/443 (18%), Positives = 141/443 (31%), Gaps = 78/443 (17%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAH-SRMVIPGGIDVHTR 75 LLIK G+ VN +I +++ I + + +TI V G ID H Sbjct: 7 LLIKNGQTVNG---MPVEIAIKEKKIAAVAATIS-GSAKETIHLEPGTYVSAGWIDDHVH 62 Query: 76 FQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDY 135 + G + G T +ID GT+ ++ + A + Sbjct: 63 CFE-KMALYYDYPDEIG----VKKGVTTVID-----AGTTGAENIHEFYDLAQQAKTNVF 112 Query: 136 SLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIA 195 L V+IS+W Q+E+ L K D ++ VI D G Sbjct: 113 GL-VNISKWGIVAQDELADLSKVQASLVKKAIQELPDFVVGIKARMSRT--VIGDNGITP 169 Query: 196 QVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKV 255 E I +E Q I + H+ S P ++ + + + + +T Sbjct: 170 L---ELAKQIQQENQEIPLM------VHIGSAPP-----HLDEILALMEKGDV---LTHC 212 Query: 256 MSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPD 315 + ++ QA K + + D H A Sbjct: 213 FNGKENGILDQATDKIKDFAWQAYNKGVVFDIGHGTDSFNFHVA---------------- 256 Query: 316 FLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKM 375 + L G KA I NG ++ +K V G Sbjct: 257 --ETALREG---------------MKAASISTDIYIRNRENGPVYDLATTMEKLRVVG-Y 298 Query: 376 DENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPD-SVKTISAKTHNSSLEYNIF 434 D + + + A+ F+L +KG + +G DADL I+ KT++ + + Sbjct: 299 DWPEIIEKVTKAPAENFHLT-QKGTLEIGKDADLTIFTIQAEEKTLTDSNGLTRV----- 352 Query: 435 EGMECRGSPLVVISQGKIVLEDG 457 + + P+ I G+I +G Sbjct: 353 --AKEQIRPIKTIIGGQIYDNEG 373 >2VUN-A nrPDB Length = 386 Score = 65.5 bits (158), Expect = 6e-11, Method: Composition-based stats. Identities = 50/160 (31%), Positives = 63/160 (39%), Gaps = 17/160 (10%) Query: 16 RLLIKG-GKIVNDD---QSFYAD-IYMEDGLIKQIGENLI--VPGGVKTIEAHSRMVIPG 68 + +IK GKIV+ D AD I +EDGLI IG + G I+A V PG Sbjct: 3 KTIIKNIGKIVSGDIKSPVLQADTIVVEDGLIAAIGGEELMKDAGDATIIDAAGSTVTPG 62 Query: 69 GIDVHTRFQMPDQGMTSAD-DFFQGTKAALAGGTTMIIDHVVP-EPGTSLLAAFDQWREW 126 +D H D DF +AL GG T +I P PG AA + Sbjct: 63 LLDTHVHVSGGDYAPRQKTMDFIS---SALHGGVTTMISAGSPHFPGRPKDAAGTKALAI 119 Query: 127 ADSKSCCDYSL-----HVDISEWHKGIQEEMEALVKDHGV 161 SKS + H KG+ EE +K GV Sbjct: 120 TLSKSYYNARPAGVKVHGGAVILEKGLTEEDFIEMKKEGV 159 >4H9M-A nrPDB Length = 840 Score = 64.3 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 75/468 (16%), Positives = 137/468 (29%), Gaps = 90/468 (19%) Query: 10 PRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGE------------NLIVPGGVKT 57 P S +I I++ ADI ++DGLI IG+ N+I+ + Sbjct: 332 PPAISLDTVITNAVIIDYTGIIKADIGIKDGLIASIGKAGNPDIMNGVFSNMIIGANTEV 391 Query: 58 IEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMII----DHVVPEPG 113 I +V G ID H + P A++ G T ++ Sbjct: 392 IAGEGLIVTAGAIDCHVHYICPQLVYE-----------AISSGITTLVGGGTGPAAGTRA 440 Query: 114 TSLLAAFDQWREWADSKSCCDYSLHVDIS-EWHKGIQEEMEALVKDHGVNSFLVYMAFKD 172 T+ + Q R +S D L+ + + +E+ ++K G ++ + Sbjct: 441 TTCTPSPTQMRLM--LQSTDDLPLNFGFTGKGSSSKPDELHEIIK-AGAMGLKLH----E 493 Query: 173 RFQLTDCQIYEVLSVIRDIGAIAQVHAEN-GDIIAEEQQRILDLGITGPEGHVLSRPEEV 231 + T I L++ +H + + E G T H Sbjct: 494 DWGSTPAAIDNCLTIAEHHDIQINIHTDTLNEAGFVEHSIAAFKGRTIHTYHS------- 546 Query: 232 EAEAVNRAITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASL-GTDGSHY 290 E A I V+ + + I L H+ Sbjct: 547 EGAGGGHAPDIIKVCGIK------------NVLPSSTNPTRPLTSNTIDEHLDMLMVCHH 594 Query: 291 WSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGK--DNF 348 + + AF S T + L G + + S +A+G+ + Sbjct: 595 LDREIPEDLAFAHS---RIRKKTIAAEDVLNDIGAISIISSD-------SQAMGRVGEVI 644 Query: 349 TLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDAD 408 + + + + + + + +++A + N A G + VG AD Sbjct: 645 SRTWQTADKMKAQTGPLKCDSSDNDNFRIRRYIAKYTINPAIANGFSQYVGSVEVGKLAD 704 Query: 409 LVIWDPDSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLED 456 LV+W P P +VI G + D Sbjct: 705 LVMWKPS----------------------FFGTKPEMVIKGGMVAWAD 730 >4CQD-A nrPDB Length = 423 Score = 64.3 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 77/481 (16%), Positives = 157/481 (32%), Gaps = 107/481 (22%) Query: 11 RITSD-RLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGG 69 ++ D L+I+ + D + DI + I +I + + I+A +V PG Sbjct: 20 HMSKDFDLIIRNAYLSEKDSVY--DIGIVGDRIIKIEAKIEGTVKDE-IDAKGNLVSPGF 76 Query: 70 IDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADS 129 +D HT TS ++ W+ Sbjct: 77 VDAHTHMDKSF---------------------------------TSTGERLPKF--WSRP 101 Query: 130 KSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFK----DRFQLTDCQIYEVL 185 + D ++ + + EE++ V +H L + D + + E + Sbjct: 102 YTR-DAAIEDGLKYYKNATHEEIKRHVIEHAHMQVLHGTLYTRTHVDVDSVAKTKAVEAV 160 Query: 186 SVIRD-----IGAIAQVHAENGDIIAEEQQ----RILDLGITGPEG-HVLSRPEEVEAEA 235 ++ I A++G + E + + LD+G G +R VE + Sbjct: 161 LEAKEELKDLIDIQVVAFAQSGFFVDLESESLIRKSLDMGCDLVGGVDPATRENNVEG-S 219 Query: 236 VNRAITIANQ--TNCPLYITKVMSKSSAEVIAQARK------KGTVV------YGEPITA 281 ++ +A + + +I + + + A+K KG V + + + Sbjct: 220 LDLCFKLAKEYDVDIDYHIHDIGTVGVYSINRLAQKTIENGYKGRVTTSAAWCFADAPSE 279 Query: 282 SLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQK 341 L Y F ++PP P L + ++ G S + Sbjct: 280 WLDEAIPLYKDSGMKFVTCFSSTPPTMP---VIKLLEAGINLG----CASDN-------- 324 Query: 342 AVGKDNFTLIPEGTNGTEERMSVIWDKAV-VTGKMDENQFVAVTSTNAAKVFNLYPRKGR 400 +F +P G NG + ++I + + + D + ++ A+V + G Sbjct: 325 ---IRDFW-VPFG-NGDMVQGALIETQRLELKTNRDLGLIWKMITSEGARVLGIEKNYG- 378 Query: 401 IAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLH 460 I VG ADLV+ + + + + L VI G+I+++D + Sbjct: 379 IEVGKKADLVVLN----------------SLSPQWAIIDQAKRLCVIKNGRIIVKDEVIV 422 Query: 461 V 461 Sbjct: 423 A 423 >3HPA-A nrPDB Length = 479 Score = 64.3 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 83/496 (16%), Positives = 147/496 (29%), Gaps = 107/496 (21%) Query: 10 PRITSDR---LLIKGGKI-VNDDQSFY----ADIYMEDGLIKQIGENLIVPG-GVKTIEA 60 P +S R LL+K + V D + A +Y+ED I +G + +P + ++ Sbjct: 21 PNTSSSRPKTLLVKHADVLVTMDDTRRELRDAGLYIEDNRIVAVGPSAELPETADEVLDL 80 Query: 61 HSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAF 120 +VIPG ++ H A A L G T + + Sbjct: 81 RGHLVIPGLVNTHHHMYQSLTRAVPA-----AQNAELFGWLTNL---------------Y 120 Query: 121 DQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQ 180 W H+ M L++ S + + +L D Sbjct: 121 KIW-------------AHLTPEMIEVSTLTAMAELLQSGCTTSSDHLYIYPNGSRLDDSI 167 Query: 181 IYE---VLSVIRDIGAIAQVHAENG----DIIAEEQQRILDLGITGPEGHVLSR------ 227 + GA++ + G ++ E + D H R Sbjct: 168 GAAQRIGMRFHASRGAMSVGQRDGGLPPDSVVEREPDILRDTQRLIETYHDEGRYAMLRV 227 Query: 228 -----PEEVEAEAVNR-AITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITA 281 + + R A +A + L+ T + + IA +R+K +G A Sbjct: 228 VVAPCSPFSVSRDLMRDAAVLAREYGVSLH-THL--AENVNDIAYSREK----FGMT-PA 279 Query: 282 SLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQK 341 D W + D L + TG AHC + + Sbjct: 280 EYAEDLGWVGHDVWHAHCVQL-----------DDAGIGLFAR---TGTGVAHCPCSNMRL 325 Query: 342 AVG-----KDNFTLIPEGTN------------GTEERMSVIWDK-AVVTGKMDENQFVAV 383 A G K +P G E R +++ + M + + + Sbjct: 326 ASGIAPVKKMRLAGVPVGLGVDGSASNDGAQMVAEVRQALLLQRVGFGPDAMTAREALEI 385 Query: 384 TSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGMECRGSP 443 + AKV N G + G AD +D + + A + + +F Sbjct: 386 ATLGGAKVLN-RDDIGALKPGMAADFAAFDL--RQPLFAGALHDPVAALVF---CAPSQT 439 Query: 444 LVVISQGKIVLEDGTL 459 + GK+V+ +G L Sbjct: 440 AYTVVNGKVVVREGRL 455 >4WGX-A nrPDB Length = 465 Score = 63.9 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 82/465 (17%), Positives = 153/465 (32%), Gaps = 48/465 (10%) Query: 17 LLIKGGKIVNDDQSFYA---DIYMEDGLIKQIG--ENLIVPGGVKTIEAHSRMVIPGGID 71 + I GG +++ + +++EDG I ++G + + V ++ I+A + ++PG ++ Sbjct: 5 IAIVGGTLIDGNGGVPVPETTVFIEDGRITKVGSTDQIEVHPNIRQIDAQGKWILPGLVN 64 Query: 72 VHTRF-----QMPDQGMTSADDF--------FQGTKAALAGGTTMIIDHVVP-EPGTSLL 117 + M G+ F + + AL GG T + D EP T Sbjct: 65 GNVHLLDGIMMMGRGGIEYLARFEGNYYKVIEEAAQIALRGGVTTVFDTWNALEPVTIAR 124 Query: 118 AAFDQWREWADSKSCCDYSLHVDISEWHKGIQEE-MEALVKDHGVNSFLVYMAFKDRFQL 176 A+ + + M ++ V S F++ Sbjct: 125 DRIAS--GAAEG---ARIFFAGTLIGMGGPFTGDFMRPSMQARTVMSRTFADRMDAMFEV 179 Query: 177 TDCQIYEVLSVIRDIGAIAQVHAENGD---IIAEEQQRILDLGITGPEGHVLSRPEEVEA 233 + L ++ + + + E G IA + LG P R +V Sbjct: 180 GMGRHLSTLPPA-EVRPLIREYLERGVDFCKIAVTDHLVGLLGFRAPYFTFSERVLDVLV 238 Query: 234 EAVNRAITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSH---- 289 + V RA L + A+++ A G E L Sbjct: 239 DEVRRAGVPLLTHTTSLEGLNTAIERDADLMIHATMTGQAPIPEETIEKLLEKQLWSEVQ 298 Query: 290 ---YWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAH-CTFNTAQKAVGK 345 + W + + S + + ++ G V G+ CT + + + Sbjct: 299 PTTIAQQAWMDSVDHPFAD-FSGRVHHENDVR-MIKAGVPLVLGTDAGCTDPDILEDMSQ 356 Query: 346 DNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGS 405 P E+ +W +A+V MD + + N AK + + G I VG Sbjct: 357 GELHERPWTLG--EDHF--VWMQAMVEKGMDPMAAILAGTANPAKAYRKFDELGSIDVGK 412 Query: 406 DADLVIWDPDSVKTISAKTHNSSLEYNIFEGME--CRGSPLVVIS 448 D+V+ D D + I+ S + + EG E G PL + Sbjct: 413 LGDVVVLDQDPLADITNMRTLSHV---VKEGREIDFHGLPLSPLV 454 >4Z42-C nrPDB Length = 572 Score = 63.9 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 79/420 (18%), Positives = 124/420 (29%), Gaps = 69/420 (16%) Query: 17 LLIKGGKIVNDD-QSFYADIYMEDGLIKQIG------------ENLIVPGGVKTIEAHSR 63 L+I IV+ AD+ + DG I IG L+V I Sbjct: 70 LVITNVTIVDARLGVIKADVGIRDGKIAGIGKSGNPGVMDGVTPGLVVGVSTDAISGEHL 129 Query: 64 MVIPGGIDVHTRFQMPDQG----MTSADDFFQGTKAALAG--GTTMIIDHVVPEPGTSLL 117 ++ GID H P Q FF G G GTT V P P Sbjct: 130 ILTAAGIDTHIHLISPQQAYHALSNGVATFFGGGIGPTDGTNGTT-----VTPGP----- 179 Query: 118 AAFDQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLT 177 W +S ++V I GV + V+ + + T Sbjct: 180 -----WNIRQMLRSVEGLPVNVGILGKGNSYGRGPLLEQAIAGVVGYKVH----EDWGAT 230 Query: 178 DCQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILD-LGITGPEGHVLSRPEEVEAEAV 236 + L + ++ VH ++ + + I G T H E Sbjct: 231 ANALRHSLRMADEMDIQVSVHTDSLNECGYVEDTIDAFEGRTIHTFH-------TEGAGG 283 Query: 237 NRAITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWA 296 A I + P + + + G E D Sbjct: 284 GHAPDIIRVASQP-NVLPSSTNPTLPY-------GVNSQAE------LFDMIMVCHNLNP 329 Query: 297 KAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGK--DNFTLIPEG 354 A V+ P T N L G + + S +A+G+ +N+ + + Sbjct: 330 NVPADVSFAESRVRPETIAAENVLHDMGVISMFSSD-------SQAMGRVGENWLRVMQT 382 Query: 355 TNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDP 414 N + + + A ++VA + N A + G + VG ADLV+WDP Sbjct: 383 ANAMKASRGKLPEDAPGNDNFRVLRYVAKITINPAIAQGVSHVIGSVEVGKMADLVLWDP 442 >3IV8-A nrPDB Length = 381 Score = 62.0 bits (149), Expect = 7e-10, Method: Composition-based stats. Identities = 71/405 (17%), Positives = 132/405 (32%), Gaps = 57/405 (14%) Query: 21 GGKIVNDDQSFYAD-IYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTR--FQ 77 KI + + + I+ + +P + ++ + + PG ID+ Sbjct: 9 NCKIYTGNDVLVKHAVIINGDKIEAVCPIESLPSEMNVVDLNGANLSPGFIDLQLNGCGG 68 Query: 78 MPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSL 137 + +A+ KA L G T + ++ ++ A RE+ L Sbjct: 69 VMFNDEITAETIDTMHKANLKSGCTSFLPTLITSSDENMRQAIAAAREYQAKYPNQSLGL 128 Query: 138 HVDISEWHKGIQEEMEAL-VKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQ 196 H+ E L V G++S D + +D + + + D+ A Sbjct: 129 HL-----------EGPYLNVMKKGIHSV-------DFIRPSDDTMIDTICANSDVIAKVT 170 Query: 197 VHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRA-ITIANQTNCPLYITKV 255 + EN E ++++ GI GH + EA + IT A ++ Sbjct: 171 LAPENNK--PEHIEKLVKAGIVVSIGH--TNATYSEARKSFESGITFAT------HLFNA 220 Query: 256 MSKSSAEV--IAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTT 313 M+ + A VY I D ++ + K V L D T Sbjct: 221 MTPMVGREPGVVGAIYDTPEVYAGIIADGFHVDYANIRIAHKIKGEKLV----LVTDATA 276 Query: 314 PDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLI-PEGTNGTEERMSVI--WDKAV 370 P G+ F K V + + GT G +++I V Sbjct: 277 PA--------------GAEMDYFIFVGKKVYYRDGKCVDENGTLG-GSALTMIEAVQNTV 321 Query: 371 VTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPD 415 + ++ + + + AK + + GRI G A+L ++D D Sbjct: 322 EHVGIALDEALRMATLYPAKAIGVDEKLGRIKKGMIANLTVFDRD 366 >4V1Y-A nrPDB Length = 494 Score = 61.6 bits (148), Expect = 8e-10, Method: Composition-based stats. Identities = 33/129 (25%), Positives = 51/129 (39%), Gaps = 33/129 (25%) Query: 9 IPRITSDRLL-IKGGKIVNDDQSFY--AD--IYMEDGLIKQIG--ENLIVPGGVKTIEAH 61 +PR + + L I+ G +V DQ D ++++DG I +G + P + I+A Sbjct: 15 VPRGSHMQTLSIQHGTLVTMDQYRRVLGDSWVHVQDGRIVALGVHAESVPPPADRVIDAR 74 Query: 62 SRMVIPGGIDVHTRFQM------PDQGMTSADDFFQ----GTKA---------------- 95 ++V+PG I+ HT P G D F G KA Sbjct: 75 GKVVLPGFINAHTHVNQILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEDVAVAVRLYCAE 134 Query: 96 ALAGGTTMI 104 A+ G T I Sbjct: 135 AVRSGITTI 143 Score = 42.7 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 16/86 (18%), Positives = 34/86 (39%), Gaps = 5/86 (5%) Query: 375 MDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIF 434 + + + + + + A+ + G I G ADL++ D +T H+ +F Sbjct: 378 LTPEKILEMATIDGARSLGMDHEIGSIETGKRADLILLDLRHPQT---TPHHHLAATIVF 434 Query: 435 EGMECRGSPLVVISQGKIVLEDGTLH 460 + V+ G +V+E+ L Sbjct: 435 QAY--GNEVDTVLIDGNVVMENRRLS 458 >2AQV-A nrPDB Length = 390 Score = 61.6 bits (148), Expect = 9e-10, Method: Composition-based stats. Identities = 60/407 (14%), Positives = 131/407 (32%), Gaps = 64/407 (15%) Query: 18 LIKGGKIVNDDQSFYADIYMEDGLIKQIGENL--IVPGGVKTIEAHSRMVIPGGIDVHTR 75 L++G + + D+ + +G I + N+ + ++ +++ PG ID H Sbjct: 11 LLQGAHLYAPEDRGICDVLVANGKIIAVASNIPSDIVPNCTVVDLSGQILCPGFIDQHVH 70 Query: 76 FQMPDQGMTSADDFFQGTKAALA---GGTTMIIDHVVPEP----GTSLLAAFDQWREWAD 128 G + A G T ++ + + SLLA E Sbjct: 71 L--IGGGGEAGPTTRTPEVALSRLTEAGVTSVVGLLGTDSISRHPESLLAKTRALNEEGI 128 Query: 129 SKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVI 188 S + HV +++++ + + V ++ + +Y + ++ Sbjct: 129 SAWMLTGAFHVPSRTITGSVEKDVAIIDR---VIGVKCAIS---DHRSAAPDVYHLANMA 182 Query: 189 RDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNC 248 + + + G + L P +L E +++ + N Sbjct: 183 AESRVGGLLGGKPGVTVFHMGDSKKAL---QPIYDLL----ENCDVPISKLLPTHVNRNV 235 Query: 249 PLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLS 308 PL+ + + E ARK G D + + P++ Sbjct: 236 PLF------EQALE---FARKGG------------TIDITSSIDE------------PVA 262 Query: 309 PDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDK 368 P + + + + ++ + + + N T I G G E + + Sbjct: 263 PAEGIARAVQAGIPLARVTLSSDGNGSQPFFD---DEGNLTHI--GVAGFETLLETV-QV 316 Query: 369 AVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPD 415 V + + +++ A NL KG I G+DADL++ P+ Sbjct: 317 LVKDYDFSISDALRPLTSSVAGFLNLTG-KGEILPGNDADLLVMTPE 362 >4LH8-A nrPDB Length = 469 Score = 60.1 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 82/495 (16%), Positives = 142/495 (28%), Gaps = 118/495 (23%) Query: 17 LLIKG-GKIVNDDQSFY----ADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGID 71 +LI+G +++ D ADI ++ I +G+NL +TI+ + +PG I+ Sbjct: 15 ILIRGLTRVITFDDQERELEDADILIDGPKIVAVGKNLSDRSVSRTIDGRGMIALPGLIN 74 Query: 72 VHTRFQM------PDQGMTSADDFFQG--TKAA------------------------LAG 99 H P + + +G T++A L G Sbjct: 75 SHQHLYEGAMRAIPQLERVTMASWLEGVLTRSAGWWRDGKFGPDVIREVARAVLLESLLG 134 Query: 100 GTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDH 159 G T + D PG + + D E A H S G E Sbjct: 135 GITTVADQHPFFPGATADSYIDATIEAATDLGI---RFHAVRSSMTLGKSE--------- 182 Query: 160 GVNSFLVYMAFKDRFQLTDCQIYEVLSVIRD--IGAIAQVHA-ENGDIIAEEQQRILDLG 216 D E + + +G I Q H E ++ + LG Sbjct: 183 --------------GGFCDDLFVEPVDRVVQHCLGLIDQYHEPEPFGMVR------IALG 222 Query: 217 ITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYG 276 P G +PE EA A +A + L+ T + G + Sbjct: 223 ---PCGVPYDKPELFEAFA-----QMAADYDVRLH-THFYEP--LDAGMSDHLYGMTPWR 271 Query: 277 EPITASLGTDGSHYWS---------KNWAKAA---AFVTSPPLSPDPTTPDFLNSLLSCG 324 +D +A A A + +P L + L G Sbjct: 272 FLEKHGWASDRVWLAHAVVPPREEIPEFADAGVAIAHLIAPDLRM-GWGLAPIREYLDAG 330 Query: 325 DLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVT 384 G+ N +G + E W + + + + Sbjct: 331 ITVGFGTTGSASNDGGNLLGDLRLAALAHRPADPNE--PEKW--------LSARELLRMA 380 Query: 385 STNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGMECRG--- 441 + +A+ P G + G AD+ W D V + G+ G Sbjct: 381 TRGSAECLG-RPDLGVLEEGRAADIACWRLDGVDRVGVHD--------PAIGLIMTGLSD 431 Query: 442 SPLVVISQGKIVLED 456 +V+ G++++E+ Sbjct: 432 RASLVVVNGQVLVEN 446 >3MKV-A nrPDB Length = 426 Score = 59.7 bits (143), Expect = 4e-09, Method: Composition-based stats. Identities = 51/322 (15%), Positives = 105/322 (32%), Gaps = 83/322 (25%) Query: 18 LIKGGKIVNDD--QSFYA-DIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHT 74 L + G +++ D +I +EDG I+++ + I I+ + ++PG ID+H Sbjct: 7 LFRNGALLDPDHPDLLQGFEILIEDGFIREVSDKPIKSSNAHVIDVKGKTIMPGLIDLHV 66 Query: 75 RFQMPDQGMTSADDFFQGT---------KAALAGGTTMIID-----HVVPEPGTSLL--- 117 + + +A L G T + D + + S L Sbjct: 67 HVVAIEFNLPRVATLPNVLVTLRAVPIMRAMLRRGFTTVRDAGGAGYPFKQAVESGLVEG 126 Query: 118 -------AAFDQWREWADSKSCCDYSL---------HVDISEWHKGIQEEMEALVKDH-- 159 A Q AD ++ DY V +E+ V++ Sbjct: 127 PRLFVSGRALSQTGGHADPRARSDYMPPDSPCGCCVRVGALGRVADGVDEVRRAVREELQ 186 Query: 160 -GVNSFLVY----MAFK----DRFQLTDCQIYEVLSVIRDIGAIAQVHA----------- 199 G + + +A F ++ +I +++ + G HA Sbjct: 187 MGADQIKIMASGGVASPTDPVGVFGYSEDEIRAIVAEAQGRGTYVLAHAYTPAAIARAVR 246 Query: 200 ------ENGDIIAEEQQRILDL------------GITGPEGHVLSRPEEVEAEAVNRAIT 241 E+G++I +E R++ EG P E++ + Sbjct: 247 CGVRTIEHGNLIDDETARLVAEHGAYVVPTLVTYDALASEGEKYGLPP----ESIAK--- 299 Query: 242 IANQTNCPLYITKVMSKSSAEV 263 IA+ L+ ++M ++ ++ Sbjct: 300 IADVHGAGLHSIEIMKRAGVKM 321 Score = 37.7 bits (86), Expect = 0.012, Method: Composition-based stats. Identities = 11/47 (23%), Positives = 27/47 (57%) Query: 375 MDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTIS 421 + + +A + +A+V + + GRI G+ AD+++ D + +K++ Sbjct: 346 LSPAEVIASATIVSAEVLGMQDKLGRIVPGAHADVLVVDGNPLKSVD 392 >2OGJ-A nrPDB Length = 417 Score = 59.3 bits (142), Expect = 4e-09, Method: Composition-based stats. Identities = 67/390 (17%), Positives = 120/390 (30%), Gaps = 81/390 (20%) Query: 34 DIYME-DGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQG 92 DI + DG I +G L P + I+A + PG +D+H G T D + Sbjct: 37 DILIGGDGKIAAVGSALQAPADTQRIDAKGAFISPGWVDLHVHI---WHGGT--DISIRP 91 Query: 93 TKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLHVDISEWHKGIQEEM 152 ++ G T ++D G++ A F +RE+ S +++ + Sbjct: 92 SECGAERGVTTLVD-----AGSAGEANFHGFREYIIEPSRERIKAFLNLGSIGLVACNRV 146 Query: 153 EALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRI 212 L + D+ I + +AEN + I Sbjct: 147 PELRDIKDI----------------------------DLDRILECYAENSEHI------- 171 Query: 213 LDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMSKSSA-EVIAQARKKG 271 +G+ HV++ V + + IA P+ + V + + + + G Sbjct: 172 --VGLKVRASHVITGSWGVTPVKLGK--KIAKILKVPM-MVHVGEPPALYDEVLEILGPG 226 Query: 272 TVVYGEPITASLGTDGSH-YWSKNWAKAAAFVTSPPLSPDPTTPD------FLNSLLSCG 324 VV G GS ++ A + D + ++ G Sbjct: 227 DVVT----HCFNGKSGSSIMEDEDLFNLAERCAGEGIRLDIGHGGASFSFKVAEAAIARG 282 Query: 325 DLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVT 384 L F+ + G + + MS + M V Sbjct: 283 LL--------PFSISTDLHGHSMNFPVWD----LATTMSKLLSV-----DMPFENVVEAV 325 Query: 385 STNAAKVFNLYPRKGRIAVGSDADLVIWDP 414 + N A V L + R+ VG AD ++D Sbjct: 326 TRNPASVIRL-DMENRLDVGQRADFTVFDL 354 >2PLM-A nrPDB Length = 406 Score = 58.9 bits (141), Expect = 6e-09, Method: Composition-based stats. Identities = 76/461 (16%), Positives = 141/461 (30%), Gaps = 95/461 (20%) Query: 17 LLIKGGKIVND--DQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHT 74 ++I I+ D + F+ + +E+G IK++ + + ++ ++V+P + HT Sbjct: 1 MIIGNCLILKDFSSEPFWGAVEIENGTIKRVLQGEVKVD----LDLSGKLVMPALFNTHT 56 Query: 75 RFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCD 134 M A+D +F++W Sbjct: 57 HAPMTLL-RGVAEDL-----------------------------SFEEW----------- 75 Query: 135 YSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYE--VLSVIRDIG 192 L + + E+M +G + MA D +E + +RD G Sbjct: 76 --LFSKVLPIEDRLTEKMAY----YGTILAQMEMARHGIAGFVDMYFHEEWIAKAVRDFG 129 Query: 193 AIAQVHA----ENGDIIAEEQQRILD----LGITGPE--GHVLSRPEEVEAEAVNRAITI 242 A + NGD ++ + G G G P E + R Sbjct: 130 MRALLTRGLVDSNGDDGGRLEENLKLYNEWNGFEGRIFVGFGPHSPYLCSEEYLKRVFDT 189 Query: 243 ANQTNCPLYITKV--MSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAA 300 A N P+ I + SK ++ G + I A + Sbjct: 190 AKSLNAPVTI-HLYETSKEEYDL-EDILNIGLK-EVKTIAAH-CVHLPERYFGVLKDIPF 245 Query: 301 FVTSPPLSPDPTTPDF--LNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGT 358 FV+ P S + ++ G G+ N + Sbjct: 246 FVSHNPASNLKLGNGIAPVQRMIEHGMKVTLGTDGAASNNSLNLF--------------F 291 Query: 359 EERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVK 418 E R++ + KA +D N + + + + A+ + G+I G +ADLV+ D D + Sbjct: 292 EMRLASLLQKAQNPRNLDVNTCLKMVTYDGAQAMGF--KSGKIEEGWNADLVVIDLDLPE 349 Query: 419 TISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTL 459 + + L G + GK + DG Sbjct: 350 MFPVQNIKNHLV------HAFSGEVFATMVAGKWIYFDGEY 384 >4R7W-A nrPDB Length = 431 Score = 58.1 bits (139), Expect = 9e-09, Method: Composition-based stats. Identities = 64/454 (14%), Positives = 129/454 (28%), Gaps = 71/454 (15%) Query: 19 IKGGKIVNDDQSFYADIYMEDGLIKQI-GENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQ 77 I ++ + F D+ +DG+I +I + + I+A R+ IP ++ H Sbjct: 3 IINARLRRQEALFTLDL--QDGIIHRITAQAAMQTADAGAIDAQGRLAIPPFVEPHIHLD 60 Query: 78 MPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSL 137 + GT L G T + Sbjct: 61 ATLTAGEPEWNR-SGT---LFEGITRWSQRKASITPEDTRQRALKTIGMLRDFGVQHVRT 116 Query: 138 HVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQ- 196 HVD+++ + + A+ ++ L +AF + E+++ ++GA Sbjct: 117 HVDVTDPSLAALQALLAVKQEAADLIDLQIVAFPQEGIESYPNGRELMTRAIEMGADVVG 176 Query: 197 --VHAENG-----DIIAEEQQRILDLG-ITGPEGHVLSRPEEVEAEAVNRAITIANQTNC 248 H EN + G + + P+ E + + Sbjct: 177 GIPHYENTRDKGVSSVMFLMDLAQRYGRLVDVHCDEIDDPQSRFLEVLAEEARV-RGMGA 235 Query: 249 PLYITKVMSKSSAE------VIAQARKKGTV-VYGEPITASLGTDGSHYWSKNWAKAAAF 301 + + + S + + + G + + L F Sbjct: 236 QVTASHTCAMGSYDNAYCSKLFRLLKASGINFISCPTESIHL--------------QGRF 281 Query: 302 VTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEER 361 + P + L G +G N I + G Sbjct: 282 DSWPKRRGVTRVAE----LDRAGINVCFAQDSIQDPWYP--LGNGNILRILD--AGLHIC 333 Query: 362 MSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTIS 421 + +D D + + + N+A+ L G +A G A+L+I D + Sbjct: 334 HMLGYD--------DLQRCLDFVTDNSARALCLGDNYG-LAEGRPANLLILDAE------ 378 Query: 422 AKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLE 455 N +E + + L I GK++L+ Sbjct: 379 ----------NDYEAVRRQARVLTSIRHGKVILQ 402 >3T8L-A nrPDB Length = 608 Score = 58.1 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 2/63 (3%) Query: 17 LLIKGGKIVN--DDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHT 74 +LI GG +V+ + ADI + LI + E + I+A V PG ID H Sbjct: 37 VLITGGTLVDVVTGELRPADIGIVGALIASVHEPASRRDAAQVIDAGGAYVSPGLIDTHM 96 Query: 75 RFQ 77 + Sbjct: 97 HIE 99 >5VGM-A nrPDB Length = 345 Score = 57.0 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 49/347 (14%), Positives = 90/347 (25%), Gaps = 53/347 (15%) Query: 71 DVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLA-AFDQWREWADS 129 D H + D + D + AL P + A + Sbjct: 14 DWHVHLRDGDVLADTVRDISRYNGRALI--------MPNTVPPVTTTEMALAYRERIMAA 65 Query: 130 KSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMA----FKDRFQLTDCQIYEVL 185 + + + + EE+ V + +Y A D + IY VL Sbjct: 66 QPQAHFEPLMALYLTDNTSPEEIRKAKASGKVVAAKLYPAGATTNSDSGVTSAKNIYPVL 125 Query: 186 SVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQ 245 ++++G + VH E +T E + R E +A Sbjct: 126 QAMQEVGMLLLVHGE----------------VTTHEVDIFDR------EKTFLDTVLAPI 163 Query: 246 TN----CPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAF 301 N + + + + + + QA G V L + +H F Sbjct: 164 VNDFPQLKIVLEHITTADAVTFVQQA---GDNVAATITAHHLLFNRNHMLVGGIR--PHF 218 Query: 302 VTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEER 361 P L + + S G+ +K G G+ Sbjct: 219 YCLPILKRATHQHALVAAATSGSKKFFLGTDSAPHAKGRKE--------AACGCAGSYTA 270 Query: 362 MSVIWDKA-VVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDA 407 + + A V + A S N + L + + + A Sbjct: 271 HAALELYAEVFEKEGKLENLEAFASFNGPDFYGLPRNQETVTLTKQA 317 >3N2C-A nrPDB Length = 423 Score = 56.2 bits (134), Expect = 4e-08, Method: Composition-based stats. Identities = 77/457 (16%), Positives = 134/457 (29%), Gaps = 90/457 (19%) Query: 34 DIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADD---FF 90 + ++ I ++ + + + I+ + V+PG ID H + + Sbjct: 26 HVVIDGERIVEVTDRPVDLPNAQAIDVRGKTVMPGFIDCHVHVLASNANLGVNATQPNIL 85 Query: 91 QGTK------AALAGGTTMIID--------HVVPEPG-TSLLAAFDQWREWADSKSCCDY 135 + A L+ G T + D E G S F + + + D+ Sbjct: 86 AAIRSLPILDAMLSRGFTSVRDAGGADWSLMQAVETGLVSGPRIFPSGKALSQTGGHGDF 145 Query: 136 SLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIA 195 D+ E GV + + + + T +I V IA Sbjct: 146 RPRGDLLEPCSCCFRTGAIARVVDGVEGVRLAVREEIQKGATQIKIMASGGVASPTDPIA 205 Query: 196 QVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKV 255 +I A + + T H + A+ RA+ V Sbjct: 206 NTQYSEDEIRAIVDE--AEAANTYVMAHAYT------GRAIARAVR-----------CGV 246 Query: 256 MSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPP-----LSPD 310 + ++ +A K +G + +L T + A F P S Sbjct: 247 RTIEHGNLVDEAAAKLMHEHGAFVVPTLVT-----YDALAKHGAEFGMPPESVAKVASVQ 301 Query: 311 PTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAV 370 + L + G GS A F I G E + Sbjct: 302 QKGRESLEIYANAGVKMGFGSD---LLGEMHAFQSGEF-RIRAEVLGNLEAL-------- 349 Query: 371 VTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLE 430 +T AA++ N+ + G IAVG+ ADLV+ D + ++ I Sbjct: 350 -----------RSATTVAAEIVNMQGQLGVIAVGAIADLVVLDGNPLEDIGVVAD----- 393 Query: 431 YNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGR 467 EG + VL+ GTL + +GR Sbjct: 394 ----EGARV-----------EYVLQRGTLVKRQAAGR 415 >2VHL-A nrPDB Length = 396 Score = 55.4 bits (132), Expect = 6e-08, Method: Composition-based stats. Identities = 79/414 (19%), Positives = 141/414 (34%), Gaps = 41/414 (9%) Query: 14 SDRLLIKGGKIVNDDQSFY-ADIYMEDGLIKQIGENLIVPGGVKTIEA-HSRMVIPGGID 71 ++ LLIK IV +++ + + DG I + K I+A +++PG ID Sbjct: 2 AESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYSKEIQAPADSVLLPGMID 61 Query: 72 VHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKS 131 + G AD + T I+ +PE GT+ A +E + Sbjct: 62 I--HIH----GGYGADTMD------ASFSTLDIMSSRLPEEGTTSFLATTITQEHGNISQ 109 Query: 132 CCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAF-KDRFQLTDCQIYEVLS-VIR 189 + +E + E+ + + S A K+ + +D ++++ Sbjct: 110 ALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVELFKKWQQEAG 169 Query: 190 DIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCP 249 + I + E D E + + D I GH +A + ++ A + Sbjct: 170 GLIKIVTLAPE-EDQHFELIRHLKDESIIASMGHT---------DADSALLSDAAKAGAS 219 Query: 250 LYITKVMSKSSAEVIAQARKKGTVVYGEPITASLG-TDGSHYWSKNWAKAAAFVTSPPLS 308 ++T + + S R+ G + + S A AF+ Sbjct: 220 -HMTHLYNAMSP---FHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSK 275 Query: 309 PDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGT-NGTEERMSVIWD 367 T L G + G Q + L+ +GT G+ +M+ Sbjct: 276 LILITDSMRAKGLKDGVYEFGG---------QSVTVRGRTALLSDGTLAGSILKMNEGAR 326 Query: 368 KAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTIS 421 +TS NAAK ++ RKG + VG DADLVI D ++ Sbjct: 327 HMREFTNCSWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILT 380 >5XGX-A nrPDB Length = 395 Score = 55.1 bits (131), Expect = 7e-08, Method: Composition-based stats. Identities = 66/405 (16%), Positives = 111/405 (27%), Gaps = 76/405 (18%) Query: 34 DIYMEDGLIKQI---GENLIVPGG---VKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSAD 87 D+ + I I G+ I VK I ++ PG ID H G Sbjct: 26 DVLIAGNKIAAIYDHGQGEITIPKQWPVKVINFDGAILTPGFIDSHAHI----TGGGGQA 81 Query: 88 DFFQ-----GTKAALAGGTTMIIDH----VVPEPGTSLLAAFDQWREWADSKSCCDYSLH 138 F G G T ++ +LL+ RE S C H Sbjct: 82 GFATQVPPVGLTEFTHAGVTTVVGLLGTDDTTRSTENLLSRVYGLREEGLSAYCWTGGYH 141 Query: 139 VDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVH 198 ++ + ++ L G+ F + + + EV+ + + + Sbjct: 142 FPLTTITGSAKSDIAFLEPVIGIGEFAI-----SDHRSSQPTFEEVIRLASETHVAGLIT 196 Query: 199 AENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVM-S 257 + G I E E + RAI T V + Sbjct: 197 GKAGVIHFHLGDG------------------ERRLELIERAIRETELPARVFNPTHVNRN 238 Query: 258 KSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFL 317 K E + KG L + W A + L Sbjct: 239 KPLFEDSCKLLSKG-------CHIDLTAFPAGTAQPGWEACDAIEMA------VERQLPL 285 Query: 318 NSLLSCGDLQVTGSAHC---TFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGK 374 + S Q + +F T G E ++ + Sbjct: 286 EQI-------TLSSDGGGCLPCFDPQGELQHMDFGRA--STLG-ETLVATL------NKG 329 Query: 375 MDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKT 419 + + + ++N A + + KG+IAVG DADL++ + T Sbjct: 330 LSLETVLPMLTSNVANILR-FKNKGQIAVGFDADLLVMNEKYEIT 373 >2BB0-A nrPDB Length = 421 Score = 54.7 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 63/415 (15%), Positives = 121/415 (29%), Gaps = 87/415 (20%) Query: 33 ADIYMEDGLIKQIGENLIVPG--GVKTIEAHSRMVIPGGIDVHTRF----------QMPD 80 A + + + I G+ G + I+ R+V PG +D HT + Sbjct: 38 AVVGIHEQKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKL 97 Query: 81 QGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLL--AAFDQWREWADSKSCCD---- 134 QG++ D QG GG + LL A F R + + + Sbjct: 98 QGISYLDILAQG------GGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSG 151 Query: 135 YSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVI------ 188 Y L + + +++ V++F+ A +Q + + + Sbjct: 152 YGLEKETELKQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKE 211 Query: 189 RDIGAIAQVHAENGDIIAEEQQRIL---DLGITGPEGHVLSRPEEVEAEAVNRAITIANQ 245 +++ + A + E G + +R L G + H AE + ++ Sbjct: 212 QELASFADIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSAD 271 Query: 246 TNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSP 305 ++ +G E T ++ G+ ++ A A Sbjct: 272 -----HLVGTS------------DEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAM-- 312 Query: 306 PLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVI 365 + G + + E + +I Sbjct: 313 ---------------IDEGVCVSLATDFNP-------------------GSSPTENIQLI 338 Query: 366 WDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWD-PDSVKT 419 A + KM + + NAA G++ G ADLVIW P+ + Sbjct: 339 MSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMYI 393 >6NBO-A nrPDB Length = 402 Score = 53.5 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 20/67 (29%), Positives = 29/67 (43%), Gaps = 3/67 (4%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRF 76 LLI+ + DD DI +E I + G +L P G E + +PG ++ HT Sbjct: 12 LLIRNVRTGADDAL---DILIEGDRIARTGPSLDAPPGCAIEEGAGAIALPGLVEGHTHL 68 Query: 77 QMPDQGM 83 GM Sbjct: 69 DKTHWGM 75 Score = 31.6 bits (70), Expect = 0.93, Method: Composition-based stats. Identities = 24/112 (21%), Positives = 40/112 (35%), Gaps = 18/112 (16%) Query: 349 TLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDAD 408 T P G+ ER +I + + + AA+ + G + G+ AD Sbjct: 309 TWTPYGSPDMLERAMLIAMRNDFRRDDALEVALECVTHGAARGCG-FDAYG-LQPGARAD 366 Query: 409 LVIWDPDSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLH 460 +V+ D + E + R +V+S GKIV +G L Sbjct: 367 VVLVDA----------------MTLAEAVVARPVRRLVVSSGKIVARNGALV 402 >3DUG-A nrPDB Length = 408 Score = 52.4 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 26/104 (25%), Positives = 42/104 (40%), Gaps = 13/104 (12%) Query: 12 ITSDRLLIKG-GKI-VNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGG 69 +TS+ LIK G + + + AD+ + +G I +IG+ I I ++IPG Sbjct: 3 LTSEDFLIKSKGYLDIQTGEIIKADLLIRNGKIAEIGK--INTKDATVISIPDLILIPGL 60 Query: 70 IDVHTRF--QMPDQGMTSADDFFQGT-------KAALAGGTTMI 104 +D H + AD GT + L G T + Sbjct: 61 MDSHVHIVGNDSKGEESIADSSHMGTVWGVVNAEKTLMAGFTTV 104 >1O12-A nrPDB Length = 376 Score = 51.2 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 79/455 (17%), Positives = 148/455 (32%), Gaps = 109/455 (23%) Query: 17 LLIKGGKIVND-DQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTR 75 ++++ IV+ D F D+ +E+G I ++ + +P GV ++PG +D H Sbjct: 13 MIVEKVLIVDPIDGEFTGDVEIEEGKIVKVEKRECIPRGV---------LMPGFVDPHIH 63 Query: 76 FQMPDQGMTSAD----DFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKS 131 G+ AD DF + + + G T + V + + R Sbjct: 64 ------GVVGADTMNCDFSEMEEFLYSQGVTTFLATTVSTSLEKMKEILRKAR------- 110 Query: 132 CCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDI 191 DY L + G+ E + K+ + K ++ ++ E+ S + + Sbjct: 111 --DYILENPSTSL-LGVHLEGPYISKEK-----KGAHSEKHIRPPSERELSEIDSPAKML 162 Query: 192 GAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVE---AEAVNRAITIANQTNC 248 ++ E+ +++ +R I GH ++ EE E V R N Sbjct: 163 TFAPEI--ESSELLLRLVKR----DIVLSAGHSIATFEEFMKFYKEGVKRITHFPNGLK- 215 Query: 249 PLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLS 308 PL+ + G + + + L DG H Sbjct: 216 PLH--H----------REIGITGAGLLLDDVKLELICDGVHLS----------------- 246 Query: 309 PDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERM----SV 364 + G + VT S D + +G E+ ++ Sbjct: 247 -REMVKLVYKVKKANGIVLVTDSISAAGLKDGTTTLGDLVVKVKDGVPRLEDGTLAGSTL 305 Query: 365 IWDKAVVT-GKMD---ENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI 420 + +AV K + V+S N+ L +GRIA G+ ADLV+ D D Sbjct: 306 FFSQAVKNFRKFTGCSITELAKVSSYNSCVELGL-DDRGRIAEGTRADLVLLDEDL---- 360 Query: 421 SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLE 455 + ++ I +G++V Sbjct: 361 ---------------------NVVMTIKEGEVVFR 374 >1YRR-A nrPDB Length = 382 Score = 51.2 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 76/405 (18%), Positives = 129/405 (31%), Gaps = 83/405 (20%) Query: 35 IYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVH------TRFQMPDQGMTSADD 88 + + DGLIK + +P ++ + ++ PG IDV +F + S + Sbjct: 21 VVIADGLIKSVCPVAELPPEIEQRSLNGAILSPGFIDVQLNGCGGVQFNDTAE-AVSVET 79 Query: 89 FFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLHVDISEWHKGI 148 KA G T + ++ + RE+ LH++ + Sbjct: 80 LEIMQKANEKSGCTNYLPTLITTSDELMKQGVRVMREYLAKHPNQALGLHLEGPWLN--- 136 Query: 149 QEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVHAENGDII--- 205 LVK N + + D + + L EN D+I Sbjct: 137 ------LVKKGTHN--------PNFVRKPDAALVDFL-------------CENADVITKV 169 Query: 206 --------AEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRA-ITIANQTNCPLYITKVM 256 AE ++ + GI GH S EA+A RA IT A LY Sbjct: 170 TLAPEMVPAEVISKLANAGIVVSAGH--SNATLKEAKAGFRAGITFA----THLY----- 218 Query: 257 SKSSAEVI--AQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTP 314 ++ I + G ++ I + DG H N A Sbjct: 219 --NAMPYITGREPGLAGAILDEADIYCGIIADGLHVDYANIRNAK--------RLKGDKL 268 Query: 315 DFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTG- 373 + + G+ F A K + N + E NGT S+ + V Sbjct: 269 CLVTDATAPA-----GANIEQFIFAGKTIYYRNGLCVDE--NGTLSGSSLTMIEGVRNLV 321 Query: 374 ---KMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPD 415 + ++ + + + A+ + R G +A G A+L + PD Sbjct: 322 EHCGIALDEVLRMATLYPARAIGVEKRLGTLAAGKVANLTAFTPD 366 >4LFY-A nrPDB Length = 372 Score = 47.0 bits (110), Expect = 3e-05, Method: Composition-based stats. Identities = 31/246 (12%), Positives = 71/246 (28%), Gaps = 30/246 (12%) Query: 105 IDHVVPEPGTSLLAAFDQWRE--WADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVN 162 I +P + A +RE A + + + + +E+ + V+ Sbjct: 63 IVMPNLKPPVTTTAQAQAYRERILAALPAGMTFEPLMTLYLTDNTPPDEIRRARESGFVH 122 Query: 163 SFLVYMA---FKDRFQLTD-CQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGIT 218 +Y A +TD + + L +++ G VH E +T Sbjct: 123 GVKLYPAGATTNSDHGVTDLAKCAKTLEAMQETGMPLLVHGE----------------VT 166 Query: 219 GPEGHVLSRPEEVEAEAVNRAITIANQ--TNCPLYITKVMSKSSAEVIAQARKKGTVVYG 276 + R E ++R +T + + + +K +A+ + A ++ Sbjct: 167 DASIDLFDR----EKVFIDRVMTPLRRDFPGLKVVFEHITTKDAADYVRDADAAPGLLGA 222 Query: 277 EPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTF 336 L + + + + P L + + + S G+ Sbjct: 223 TITAHHLLYNRNALFVGGIR--PHYYCLPVLKRETHRVALVEAATSGNPRFFLGTDSAPH 280 Query: 337 NTAQKA 342 K Sbjct: 281 ARDAKE 286 >4DYK-A nrPDB Length = 451 Score = 45.8 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 71/465 (15%), Positives = 138/465 (29%), Gaps = 115/465 (24%) Query: 35 IYMEDGLIKQIGENLIVP--GGVKTIEAHSRMVIPGGIDVHTRFQM-------------- 78 + + DG I + G + E ++ PG ++ H M Sbjct: 32 LGIRDGQIALVAPREQAMRHGATEIRELPGMLLAPGLVNAHGHSAMSLFRGLADDLPLMT 91 Query: 79 -------PDQGMTSADDF-FQGTKAALA----GGTTMIIDH---------VVPEPGTSLL 117 P +G ++DF GT+ A+A GG T D VV + G Sbjct: 92 WLQDHIWPAEGQWVSEDFIRDGTELAIAEQVKGGITCFSDMYFYPQAICGVVHDSGVRAQ 151 Query: 118 AAFDQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLT 177 A ++ ++ + + + ++ Sbjct: 152 VAIPVLDFPIPGARDSAEAIRQGMALFDDLKHH-----------PRIRIAFGPHAPYTVS 200 Query: 178 DCQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVN 237 D ++ ++L + ++ A Q+H + E +Q + G RP ++ Sbjct: 201 DDKLEQILVLTEELDASIQMHVH--ETAFEVEQAMERNG---------ERP----LARLH 245 Query: 238 RAITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAK 297 R + + + ++ +V++ N Sbjct: 246 RLGLL----GPRFQAVHMTQVDNDDLAMLVETNSSVIHC--------------PESNLKL 287 Query: 298 AAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNG 357 A+ F P+ + ++ G+ N +G Sbjct: 288 ASGFC---PV------EKLWQAGVNV----AIGTDGAASNNDLDLLG------------- 321 Query: 358 TEERMSVIWDKAV--VTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPD 415 E R + + KAV +D ++ + + + N A+ L G + G ADLV +D Sbjct: 322 -ETRTAALLAKAVYGQATALDAHRALRMATLNGARALGLERLIGSLEAGKAADLVAFDLS 380 Query: 416 SVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLH 460 + S L Y G +C V G+ +L+DG L Sbjct: 381 GLAQQPVYDPVSQLIYAS--GRDC---VRHVWVGGRQLLDDGRLL 420 >3IGH-X nrPDB Length = 486 Score = 45.4 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 12/81 (14%), Positives = 28/81 (34%), Gaps = 8/81 (9%) Query: 14 SDRLLIKGGKIVNDDQSFY--ADIYMEDGLI-----KQIGENLIVPGGVKTIEAHSRMVI 66 S + LI G I + + + G + ++ + ++ G + ++ + V+ Sbjct: 2 SLKALI-NGTIYTSFNPLKKVSGLVISHGKVIYAGDSEVAKKIVELSGGEIVDLKGKYVM 60 Query: 67 PGGIDVHTRFQMPDQGMTSAD 87 P D H + D Sbjct: 61 PAFFDSHLHLDELGMSLEMVD 81 >3JZE-A nrPDB Length = 372 Score = 45.4 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 37/284 (13%), Positives = 76/284 (26%), Gaps = 49/284 (17%) Query: 71 DVHTRFQMPDQGMTSA-DDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADS 129 D H + D T +A I + + A +R+ Sbjct: 39 DWHVHLRDGDMLKTVVPYTSEIYGRA---------IVMPNLASPITTVDAAIAYRQRILD 89 Query: 130 KSCC--DYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRF----QLTDCQIYE 183 D++ + +E+E + + +Y A + I Sbjct: 90 AVPAGHDFTPLMTCYLTDSLDADELERGFHEGVFTAAKLYPANATTNSSHGVTSVDAIMP 149 Query: 184 VLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIA 243 VL + +G VH E +T + + R EA ++ + Sbjct: 150 VLERMEKLGIPLLVHGE----------------VTHADVDIFDR----EARFIDTVMEPL 189 Query: 244 NQTNCPLYIT--KVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAA-- 299 Q L + + +K +A+ + G IT + + Sbjct: 190 RQRLTALKVVFEHITTKDAAQYVRD----GNDYLAATIT----PQHLMFNRNDMLVGGIR 241 Query: 300 AFVTSPPLSPDPTTPDFLNSLLSCGDLQV-TGSAHCTFNTAQKA 342 + P+ L L++ G + G+ + +K Sbjct: 242 PHLYCLPILKRNIHQQALRELVASGFTRAFLGTDSAPHSRHRKE 285 >4F0R-A nrPDB Length = 447 Score = 45.4 bits (106), Expect = 7e-05, Method: Composition-based stats. Identities = 79/487 (16%), Positives = 152/487 (31%), Gaps = 113/487 (23%) Query: 11 RITSDRLLIKGGKIVNDDQSFYAD-IYMEDGLIKQIGENLIVPG--GVKTIEAHSRMVIP 67 +I S R +I + D + I + DG I I G + +E +++P Sbjct: 8 KIISARWII---TVETDGEVLENHAIAIRDGKIAAIIPAADAAGLEADERLELPDHVLMP 64 Query: 68 GGIDVHTRFQM---------------------PDQGMTSADDF-FQGTKAA----LAGGT 101 G I++H M P +G DDF F G+ A + GGT Sbjct: 65 GLINLHGHSAMSLLRGLADDKALMDWLTNYIWPTEGKHVHDDFVFDGSLLAMGEMIRGGT 124 Query: 102 TMIIDHVVPEPGTS---LLAAFDQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKD 158 T I D + L + + + + +Y+ S I + M + Sbjct: 125 TTINDMYFYNAAVARAGLASGMRTFVGCSILEFPTNYA-----SNADDYIAKGMAERSQF 179 Query: 159 HGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGIT 218 G + +A + ++D +V+++ + H + E + + G Sbjct: 180 LGEDLLTFTLAPHAPYTVSDDTFRKVVTLAEQEDMLI--HCHIHETADEVNNSVKEHG-- 235 Query: 219 GPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEP 278 RP + R ++ + ++ + E+ A+ Sbjct: 236 -------QRP----LARLQRLGLLSPRLVA-AHMVHLNDAE-VELAAR------------ 270 Query: 279 ITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNT 338 L T + + A + V+ L+ G G+ N Sbjct: 271 --HGLSTAHNPASNMKLASGISPVS---------------KLMDAGVAVGIGTDGAASNN 313 Query: 339 AQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQF-----VAVTSTNAAKVFN 393 + E R++ + K G +D + + + N A+ Sbjct: 314 KLDMLA--------------ETRLAALLAKV---GTLDPTSVPAAAAIRMATLNGARALG 356 Query: 394 LYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIV 453 + + G + VG ADL+ D ++T A S + Y G E V +G+ + Sbjct: 357 IADKVGSVKVGKQADLIALDLAQLETAPAFDPISHVVYA--AGRE---QVSHVWVKGRAL 411 Query: 454 LEDGTLH 460 + + L Sbjct: 412 MRERKLT 418 >3MTW-A nrPDB Length = 403 Score = 45.0 bits (105), Expect = 9e-05, Method: Composition-based stats. Identities = 26/108 (24%), Positives = 45/108 (41%), Gaps = 17/108 (15%) Query: 9 IPRITSDRLL-IKGGKIVNDDQSFYADIYMEDGLIKQIGE-NLIVPGGVKTIEAHSRMVI 66 I +++ RLL + GK V++ + + DG I IG+ VP G ++ ++ Sbjct: 3 IKAVSAARLLDVASGKYVDNPL-----VIVTDGRITSIGKKGDAVPAGATAVDLPGVTLL 57 Query: 67 PGGIDVHTRFQMP-----DQGMTSADDFFQGTKAA-----LAGGTTMI 104 PG ID+H + +D F+ + A L G T + Sbjct: 58 PGLIDMHVHLDSLAEVGGYNSLEYSDRFWSVVQTANAKKTLEAGFTTV 105 >3LNP-A nrPDB Length = 468 Score = 43.9 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 66/466 (14%), Positives = 137/466 (29%), Gaps = 113/466 (24%) Query: 35 IYMEDGLIKQIGENLIVP-GGVKTIEAHSRMVIPGGIDVHTRF----------QMPDQG- 82 + ++DG+I I +T++ ++++PG ++ H +P Sbjct: 53 LLIKDGIILAIEPQSSCQIPATETLDLGQQVLMPGWVNAHGHAAMSLFRGLADDLPLMTW 112 Query: 83 ---------MTSADDFF--QGTKAALA----GGTTMIIDHVVPEPGTSLLAAFDQWREWA 127 D+ F QGT+ A+A GTT D P S AA A Sbjct: 113 LQEHVWPAEAQHVDEHFVKQGTELAIAEMIQSGTTTFADMYF-YPQQSGEAALA-----A 166 Query: 128 DSKSCCDYSLHVDISEWHKGIQEEM------------EALVKDHGVNSFLVYMAFKDRFQ 175 ++ C ++ +D + +E + + G+ + + Sbjct: 167 GIRAVC-FAPVLDFPTNYAQNADEYIRKAIECNDRFNNHPMNEQGLV--QIGFGPHAPYT 223 Query: 176 LTDCQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEA 235 ++D + E+ + + Q+H D E + RP + Sbjct: 224 VSDEPLKEITMLSDQLDMPVQIHLHETDFEVSESLETFNK-----------RP----TQR 268 Query: 236 VNRAITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNW 295 + + + +C + + I +K G + H N Sbjct: 269 LADIGFLNERVSC----VHMTQVDDGD-IKILQKTGASI-------------IHCPESNL 310 Query: 296 AKAAAFVTSPPLSPDPTTPDF-LNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEG 354 A+ F LS + S DL + T A+ + Sbjct: 311 KLASGFCPIAKLSAANIPLAIGTDGAASNNDLDMFS------ETKTAALLAKGVSQDASA 364 Query: 355 TNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDP 414 E + + + A+ + G + G AD+ D Sbjct: 365 IPAIEA--------------------LTMATLGGARALGIDDITGSLKPGKAADIQAIDL 404 Query: 415 DSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLH 460 + T+S++ + + ++ + V G+ +L++G L Sbjct: 405 N---TLSSQPVFDPVSHMVYCTKSTQ--VSHVWVNGRCLLKNGELT 445 >3ICJ-A nrPDB Length = 534 Score = 42.4 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 12/71 (16%), Positives = 23/71 (32%), Gaps = 13/71 (18%) Query: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRF 76 L+I +++ S A I ++ G + I+ + V+P D H Sbjct: 58 LVISNERVLYAGDSSTA------LRIAELA-------GGEIIDLKGKFVMPAFFDSHLHL 104 Query: 77 QMPDQGMTSAD 87 + D Sbjct: 105 DELGMSLEMVD 115 >2P9B-A nrPDB Length = 458 Score = 42.4 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 37/234 (15%), Positives = 62/234 (26%), Gaps = 50/234 (21%) Query: 20 KGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKT--IEAHSRMVIPGGIDVHTRF- 76 K G I+ + DG I+Q+ ++ + ++ ++V+PG I+ HT Sbjct: 26 KAGTILRNMTIVVG----ADGRIEQVAPSIETSIPAEYHYLDGTGKIVMPGLINAHTHLF 81 Query: 77 -----------------------QMPDQGMTSADDFFQGTKAALAGGTTMIIDH------ 107 P A L G T I Sbjct: 82 SQGKPLNPKLATPKGQRMVATFAHSPLGKPYMAATVKHNATTLLESGVTTIRTLGDVGYE 141 Query: 108 VVPEPGTSLLAAFDQWREWADSKSCCDYSLHVD-ISEWHKGIQEEMEALVK---DHGVNS 163 VV R A H + G EE V GVN+ Sbjct: 142 VVTLRDQIDAGQILGPRILASGPLMAIPEGHGAPLIALTSGTPEEARTAVAQNLKAGVNA 201 Query: 164 FLVY----------MAFKDRFQLTDCQIYEVLSVIRDIGAIAQVHAENGDIIAE 207 + + Q++ Q+ + G I HA++ + + Sbjct: 202 IKIAATGGVTDAQEIGEAGSPQMSVEQMRAICDEAHQYGVIVGAHAQSPEGVRR 255 >2QS8-A nrPDB Length = 418 Score = 42.0 bits (97), Expect = 8e-04, Method: Composition-based stats. Identities = 88/490 (17%), Positives = 151/490 (30%), Gaps = 145/490 (29%) Query: 16 RLLIKGGKIVN---DDQSFYADIYMEDGLIKQIGENLIVPGGVK-TIEAHSRMVIPGGID 71 + LI GK+++ D I ++ +I I + I + I+ V+PG +D Sbjct: 8 KTLIHAGKLIDGKSDQVQSRISIVIDGNIISDIKKGFISSNDFEDYIDLRDHTVLPGLMD 67 Query: 72 VHTRF--------QMPDQGMTSADDFFQGTKAAL--AGGTTMIIDHVVPEPGTSLLAAFD 121 +H F Q P + A + G T + + G S L A Sbjct: 68 MHVHFGQEYQSKAQAPIKVEREMQAILATQHAYVTFKSGFTTV-----RQVGDSGLVAIS 122 Query: 122 QWREW-----------ADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNS--FLVYM 168 A K+ H D + + ++ + V + GV + + VY Sbjct: 123 LRDAINSGKLAGPRIFAAGKTIATTGGHADPT--NGKAVDDYDYPVPEQGVVNGPYEVYA 180 Query: 169 A----FKDRF---------------------QLTDCQIYEVLSVIRDIGAIAQVHAENGD 203 A +KD Q T ++ V+S +D G VHA Sbjct: 181 AVRQRYKDGADGIKITVTGGVLSVAKSGQNPQFTQEEVDAVVSAAKDYGMWVAVHAHG-- 238 Query: 204 IIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMSKSSAEV 263 AE +R + G+ E H ++ EA++ I N Y V + S+ E Sbjct: 239 --AEGMKRAIKAGVDSIE-HG----TFMDLEAMDLMIE-----NGTYY---VPTISAGEF 283 Query: 264 IAQARKKGTVVYGE---PITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSL 320 +A+ + K + E P AS+G S + K + K Sbjct: 284 VAE-KSKIDNFFPEIVRPKAASVGPQISDTFRKAYEKGVKIA------------------ 324 Query: 321 LSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQF 380 G+ + F + E M + + Sbjct: 325 --------FGTDAG---VQKHGTNWKEFVYM------VENGMPAM-------------KA 354 Query: 381 VAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGMECR 440 + + AK+ + + G I G ADL+ +++ N E + Sbjct: 355 IQSATMETAKLLRIEDKLGSIESGKLADLI-----------------AVKGNPIEDISVL 397 Query: 441 GSPLVVISQG 450 + VVI G Sbjct: 398 ENVDVVIKDG 407 >2OOF-A nrPDB Length = 416 Score = 41.2 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 62/413 (15%), Positives = 123/413 (29%), Gaps = 83/413 (20%) Query: 35 IYMEDGLIKQIG--ENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQG 92 + + +G I + ++L P + ++V PG ID HT F G Sbjct: 32 LGVHEGRIHALVPMQDLKGPYPAHWQDMKGKLVTPGLIDCHTHL------------IFAG 79 Query: 93 TKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLHVDISEWHKGIQEEM 152 ++A + + + G R+ S + + + + Sbjct: 80 SRAE---------EFELRQKGVPYAE---IARKGGGIISTVRATRAASEDQLFELALPRV 127 Query: 153 EALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRI 212 ++L+++ GV + + K + LT ++L V R +G + + + Sbjct: 128 KSLIRE-GVTTVEI----KSGYGLTLEDELKMLRVARRLG---------EALPIRVKTTL 173 Query: 213 LDLGITGPEG--HVLSRPEEVEAEAVNRAITIANQTNCPLYITKV--MSKSSAEVIAQAR 268 L PE S E + E + A ++ + + +V A Sbjct: 174 LAAHAVPPEYRDDPDSWVETICQEIIPAAAEAGLADAVDVFCEHIGFSLAQTEQVYLAAD 233 Query: 269 KKGTVVY----------GEPITASLG---TDGSHYWSKNWAKA-AAFVTSPPLSP----- 309 + G V G + A+ G D Y +A A L P Sbjct: 234 QYGLAVKGHMDQLSNLGGSTLAANFGALSVDHLEYLDPEGIQALAHRGVVATLLPTAFYF 293 Query: 310 -DPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDK 368 T + +L G S M++ Sbjct: 294 LKETKLPPVVALRKAGVPMAVSSDINPGTAP---------------IVSLRMAMNMACTL 338 Query: 369 AVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTIS 421 + + +A + +AA+ + G++ VG AD ++W+ +S Sbjct: 339 F----GLTPVEAMAGVTRHAARALGEQEQLGQLRVGMLADFLVWNCGHPAELS 387 >1R9X-A nrPDB Length = 430 Score = 40.8 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 39/229 (17%), Positives = 82/229 (35%), Gaps = 42/229 (18%) Query: 19 IKGGKIVNDDQSFYADIYMEDGLIKQI-GENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQ 77 I ++ ++ + I+++DG I I ++ ++P +++A +VIP ++ H Sbjct: 12 IINARLPGEEGLWQ--IHLQDGKISAIDAQSGVMPITENSLDAEQGLVIPPFVEPHIHLD 69 Query: 78 MP-DQGMTSAD---DFFQG-----TKAAL------------------AGGTTMIIDHV-V 109 G + + F+G + AL A G + HV V Sbjct: 70 TTQTAGQPNWNQSGTLFEGIERWAERKALLTHDDVKQRAWQTLKWQIANGIQHVRTHVDV 129 Query: 110 PEPGTSLLAAFDQWREWADSKSCCDYS----LHVDISEWHKGIQEEMEALVKDHGVNSFL 165 + + L A + ++ D I + G EAL V + Sbjct: 130 SDATLTALKAMLEVKQEVAP--WIDLQIVAFPQEGILSYPNGEALLEEALRLGADVVGAI 187 Query: 166 VYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILD 214 + F + + +++ ++ + + VH D I +EQ R ++ Sbjct: 188 PHFEFTREYGV--ESLHKTFALAQKYDRLIDVHC---DEIDDEQSRFVE 231 >3GGM-A nrPDB Length = 81 Score = 40.8 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 17/65 (26%), Positives = 29/65 (44%), Gaps = 5/65 (7%) Query: 17 LLIKGGKIVNDDQSFY--ADIYMEDGLIKQIGENLIVPGGVKT---IEAHSRMVIPGGID 71 +++ GKI D S + I + DGLI +G + ++ + I+ + IPG D Sbjct: 6 MILYNGKITTLDPSQPEVSAIAITDGLITAVGGDELLNSATEKTKKIDLKRKRAIPGLND 65 Query: 72 VHTRF 76 H Sbjct: 66 SHIHV 70 >4WHB-E nrPDB Length = 461 Score = 40.0 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 13/88 (14%), Positives = 29/88 (32%), Gaps = 16/88 (18%) Query: 35 IYMEDGLIKQIGEN--LIVPGGVKTIEAHSRMVIPGGIDVHTRFQMPDQ----------- 81 + +E +G + VP G ++ + R ++PG ++ + Sbjct: 25 VIVEGDRFATVGPSDSTPVPEGATVVDGNRRWMVPGYVNGNVHLLDAWMFMAGPGTIEYL 84 Query: 82 ---GMTSADDFFQGTKAALAGGTTMIID 106 + + + AL G T + D Sbjct: 85 ARWEGRYVEVIEEAAQLALRNGVTTVFD 112 Score = 36.2 bits (82), Expect = 0.045, Method: Composition-based stats. Identities = 14/55 (25%), Positives = 26/55 (47%) Query: 366 WDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI 420 W +++V M + ++ + N A+ + + G + G AD V+ D D V I Sbjct: 375 WTQSMVEKGMSPLEAISAATINVARAYGKADQIGSVETGKLADFVLLDQDPVDDI 429 >3MDW-A nrPDB Length = 453 Score = 37.7 bits (86), Expect = 0.012, Method: Composition-based stats. Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 3/69 (4%) Query: 399 GRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGT 458 G +AVG ADL++ D + SA+ + +F G + + V+ G+ V+ DG Sbjct: 377 GSLAVGRRADLLVLDGNDPYLASAEGDALLNRW-LFAGGDRQ--VRDVMVAGRWVVRDGR 433 Query: 459 LHVTEGSGR 467 E S R Sbjct: 434 HAGEERSAR 442 >2OOD-A nrPDB Length = 475 Score = 37.7 bits (86), Expect = 0.015, Method: Composition-based stats. Identities = 13/43 (30%), Positives = 20/43 (46%), Gaps = 3/43 (6%) Query: 37 MEDGLIKQIGENLIVP---GGVKTIEAHSRMVIPGGIDVHTRF 76 + DG+IK G + GV+ R+++PG ID H Sbjct: 40 VTDGVIKAFGPYEKIAAAHPGVEITHIKDRIIVPGFIDGHIHL 82 >2PAJ-A nrPDB Length = 492 Score = 37.0 bits (84), Expect = 0.023, Method: Composition-based stats. Identities = 15/61 (24%), Positives = 25/61 (40%), Gaps = 3/61 (4%) Query: 18 LIKGGKIVNDDQSFYA--DIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTR 75 ++ GG+ DD S DI + I IG L G ++A ++ P ++ H Sbjct: 20 IMTGGRGTADDPSRVPGPDIRIVGDTIDAIGA-LAPRPGETIVDATDCVIYPAWVNTHHH 78 Query: 76 F 76 Sbjct: 79 L 79 >2I9U-A nrPDB Length = 439 Score = 36.6 bits (83), Expect = 0.030, Method: Composition-based stats. Identities = 18/65 (27%), Positives = 28/65 (43%), Gaps = 13/65 (20%) Query: 13 TSDRL-LIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVP-GGVKTIEAHSRMVIPGGI 70 TSD+ ++K IV + DG I + NL G I+ + ++IPG Sbjct: 22 TSDKFTIMKDSYIV-----------VIDGKIASVSSNLPDKYKGNPIIDFRNNIIIPGMN 70 Query: 71 DVHTR 75 D+H Sbjct: 71 DLHAH 75 >4DZH-A nrPDB Length = 472 Score = 36.6 bits (83), Expect = 0.033, Method: Composition-based stats. Identities = 69/412 (16%), Positives = 128/412 (31%), Gaps = 85/412 (20%) Query: 35 IYMEDGLIKQI---GENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSAD---- 87 + + +G+I + + + +T+ ++PG ++ HT M + D Sbjct: 38 VAVSNGVIVAVLPTADARVRFAPARTVSRPDAALMPGLVNAHTHNPMTLLRGVADDLPLM 97 Query: 88 ----DFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLHVDISE 143 +AA+ G + LA + R +C + + + Sbjct: 98 VWLQQHIWPVEAAVIG--------PEFVADGTTLAIAEMLRG---GTTCVNENYFFADVQ 146 Query: 144 WHKGIQEEMEALVKDHGVNSF--LVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVHAEN 201 A+ K HG + V + F + +D + + A Sbjct: 147 ---------AAVYKQHGFRALVGAVIIDFPTAWASSDDEYF----------------ARA 181 Query: 202 GDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYI-TKVMSKSS 260 G++ + + L P P V R +A+Q + P+++ T ++ Sbjct: 182 GELHDQWRDDPLISTAFAPHA-----PYTVNDANFERVRMLADQLDMPVHLHTHETAQEV 236 Query: 261 AEVIAQARKKGT---VVYGEPITASLGTDGSHYWSKNWAKAAAFVTS----PPLSPDPTT 313 A+ +AQ ++ G + + A S P + + Sbjct: 237 ADSVAQYGQRPLARLDRLGLVNDRLIAVHMTQLTEAEIHLCAERGVSVVHCPESNLKLAS 296 Query: 314 PDFLNSLLSCGDLQV-TGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVT 372 L + + G+ C N D F+ E R + I KAV Sbjct: 297 GFCPACALQRASVNLAIGTDGCASNND-----LDMFS---------ENRTAAILAKAVAN 342 Query: 373 GKMDENQFVAVTSTNAAKV-----FNLYPRKGRIAVGSDADLVIWDPDSVKT 419 D A T+ AA + R G I VG ADLV D +++T Sbjct: 343 ---DATALDAATTLRAATLGGARALGFGDRIGSIEVGKQADLVCVDLSALET 391 >3B2Q-A nrPDB Length = 469 Score = 36.2 bits (82), Expect = 0.044, Method: Composition-based stats. Identities = 23/130 (17%), Positives = 47/130 (36%), Gaps = 12/130 (9%) Query: 413 DPDSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRK 472 DP + ++ + ++ EY +E G ++VI + + R+ Sbjct: 224 DPAVERIVTPRMALTAAEYLAYE----HGMHVLVILTDITNYAEALRQMGAARNEVPGRR 279 Query: 473 PFPDFVYKRIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVT----PASSAKTSPAKQQA 528 +P ++Y + + L E G+ +G G V ++ + P + Q Sbjct: 280 GYPGYMYTDL---ATLYERAGIVKGA-KGSVTQIPILSMPGDDITHPIPDLSGYITEGQI 335 Query: 529 PPVRNLHQSG 538 R LH+ G Sbjct: 336 VVARELHRKG 345 >6FV3-A nrPDB Length = 401 Score = 34.3 bits (77), Expect = 0.16, Method: Composition-based stats. Identities = 17/84 (20%), Positives = 30/84 (35%), Gaps = 7/84 (8%) Query: 37 MEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAA 96 + + +G + + A V+PG +D T G SA + +A Sbjct: 38 IASDRVVAVGAGAPPAQADRNLGAA--TVVPGFVD--THLHGGGGGNFSAATDDETARAV 93 Query: 97 L---AGGTTMIIDHVVPEPGTSLL 117 A G+T ++ +V LL Sbjct: 94 ALHRAHGSTTLVASLVTAGPEDLL 117 >2WJF-A nrPDB Length = 247 Score = 32.7 bits (73), Expect = 0.50, Method: Composition-based stats. Identities = 33/160 (20%), Positives = 57/160 (35%), Gaps = 18/160 (11%) Query: 68 GGIDVHTRF-QMPDQGMTSADDFFQGTKAALA----GGTTMIIDH------VVPEPGTSL 116 G ID+H+ D G S ++ +KA LA G I+ + P + Sbjct: 4 GMIDIHSHIVFDVDDGPKSREE----SKALLAESYRQGVRTIVSTSHRRKGMFETPEEKI 59 Query: 117 LAAFDQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQL 176 F Q RE A + + + + +++E +S + F Sbjct: 60 AENFLQVREIAKEVASDLVIAYGAEIYYTPDVLDKLEKKRIPTLNDSRYALIEFSMNTPY 119 Query: 177 TDCQIYEVLSVIRDIG-AIAQVHAENGDIIAEEQQRILDL 215 D I+ LS I +G H E D + ++R+ +L Sbjct: 120 RD--IHSALSKILMLGITPVIAHIERYDALENNEKRVREL 157 >5N6M-A nrPDB Length = 531 Score = 32.0 bits (71), Expect = 0.79, Method: Composition-based stats. Identities = 28/116 (24%), Positives = 47/116 (40%), Gaps = 19/116 (16%) Query: 403 VGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGME--------CRGSPLVV-ISQGKIV 453 D DL++W P++ I + + Y G G P+ ++ GK Sbjct: 278 PQQDVDLIVW-PETAVPI---LQDMASGYLGAMGQVADEKNAALITGVPVRERLADGKSR 333 Query: 454 LEDGTLHVTEGSGRYIPRK--PFPDFVYKRIKARSRLA----ELRGVPRGLYDGPV 503 +G V EG+G Y+ +K PF ++V + R +A + RG D P+ Sbjct: 334 YFNGITVVGEGAGTYLKQKLVPFGEYVPLQDLLRGLIAFFDLPMSDFARGPADQPL 389 >3SLC-A nrPDB Length = 415 Score = 31.2 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 21/105 (20%), Positives = 43/105 (40%), Gaps = 4/105 (3%) Query: 338 TAQKAVGKDNFTLIPEGT--NGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLY 395 AQK T I G + SV+ D++V+ G D F + N A + + Sbjct: 90 LAQKPELSAQLTAIGHRIVHGGEKYTSSVVIDESVIQGIKDSASFAPL--HNPAHLIGIA 147 Query: 396 PRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGMECR 440 D ++ ++D +T+ +++ +L Y++++ R Sbjct: 148 EALKSFPQLKDKNVAVFDTAFHQTMPEESYLYALPYSLYKEHGVR 192 >5YDI-A nrPDB Length = 553 Score = 30.8 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 21/82 (25%), Positives = 30/82 (36%), Gaps = 10/82 (12%) Query: 209 QQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMSKSSAEVIAQAR 268 Q+ IL G ++SR EA RA+ +A CP SK S + + R Sbjct: 219 QRAILQSGSPTAPWALVSR-----EEATLRALRLAEAVGCP----HEPSKLS-DAVECLR 268 Query: 269 KKGTVVYGEPITASLGTDGSHY 290 K V +LG + Sbjct: 269 GKDPHVLVNNEWGTLGICEFPF 290 >5YDJ-A nrPDB Length = 737 Score = 30.8 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 21/82 (25%), Positives = 30/82 (36%), Gaps = 10/82 (12%) Query: 209 QQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMSKSSAEVIAQAR 268 Q+ IL G ++SR EA RA+ +A CP SK S + + R Sbjct: 380 QRAILQSGSPTAPWALVSR-----EEATLRALRLAEAVGCP----HEPSKLS-DAVECLR 429 Query: 269 KKGTVVYGEPITASLGTDGSHY 290 K V +LG + Sbjct: 430 GKDPHVLVNNEWGTLGICEFPF 451 >1ZZM-A nrPDB Length = 259 Score = 30.4 bits (67), Expect = 2.1, Method: Composition-based stats. Identities = 23/140 (16%), Positives = 45/140 (32%), Gaps = 21/140 (15%) Query: 69 GIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWAD 128 ID H F P D+ +AA AG +I+ + F + A+ Sbjct: 5 FIDTHCHFDFPPFSG---DEEASLQRAAQAGVGKIIV-------PATEAENFARVLALAE 54 Query: 129 --SKSCCDYSLHVDISEWHKGI-QEEMEALVKDH-------GVNSFLVYMAFKDRFQLTD 178 LH + E H + E+++ ++ G ++ +F+ Sbjct: 55 NYQPLYAALGLHPGMLEKHSDVSLEQLQQALERRPAKVVAVGEIGLDLF-GDDPQFERQQ 113 Query: 179 CQIYEVLSVIRDIGAIAQVH 198 + E L + + +H Sbjct: 114 WLLDEQLKLAKRYDLPVILH 133 >5U03-A nrPDB Length = 591 Score = 29.3 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 9/43 (20%), Positives = 17/43 (39%) Query: 35 IYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQ 77 I + G+I IG+ +I +++ V ID + Sbjct: 4 ILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINID 46 >2VO1-A nrPDB Length = 295 Score = 29.3 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 9/43 (20%), Positives = 17/43 (39%) Query: 35 IYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQ 77 I + G+I IG+ +I +++ V ID + Sbjct: 26 ILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINID 68 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.135 0.360 Lambda K H 0.267 0.0413 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 21,521,805 Number of Sequences: 36641 Number of extensions: 864802 Number of successful extensions: 3038 Number of sequences better than 10.0: 98 Number of HSP's better than 10.0 without gapping: 114 Number of HSP's successfully gapped in prelim test: 37 Number of HSP's that attempted gapping in prelim test: 2653 Number of HSP's gapped (non-prelim): 214 length of query: 572 length of database: 10,336,785 effective HSP length: 102 effective length of query: 470 effective length of database: 6,599,403 effective search space: 3101719410 effective search space used: 3101719410 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 62 (28.5 bits)