BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q16539 (360 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4EWQ-A nrPDB 749 0.0 3OHT-A nrPDB 661 0.0 3GC9-A nrPDB 570 e-163 1CM8-A nrPDB 491 e-139 4MYG-A nrPDB 464 e-131 3E7O-A nrPDB 339 1e-93 5AWM-A nrPDB 333 6e-92 5NGU-A nrPDB 333 7e-92 4QTB-A nrPDB 332 2e-91 2XS0-A nrPDB 330 5e-91 1JNK-A nrPDB 327 4e-90 6DTL-A nrPDB 323 9e-89 4IC8-A nrPDB 317 5e-87 4ZSG-A nrPDB 316 8e-87 2F9G-A nrPDB 313 1e-85 3FI2-A nrPDB 310 5e-85 5Z33-A nrPDB 303 7e-83 4O2Z-A nrPDB 273 8e-74 4QNY-A nrPDB 262 1e-70 3OZ6-A nrPDB 235 3e-62 3RP9-A nrPDB 231 5e-61 3PG1-A nrPDB 220 8e-58 2I6L-A nrPDB 218 3e-57 3NIE-A nrPDB 205 2e-53 3N9X-A nrPDB 204 6e-53 2BPM-A nrPDB 191 3e-49 3NIZ-A nrPDB 190 9e-49 1V0B-A nrPDB 185 2e-47 4KRC-A nrPDB 180 8e-46 6GU6-A nrPDB 176 2e-44 1UA2-A nrPDB 174 5e-44 4AU8-A nrPDB 172 2e-43 1G3N-A nrPDB 167 6e-42 5G6V-A nrPDB 165 3e-41 4BBM-A nrPDB 164 4e-41 4AGU-A nrPDB 163 1e-40 3ZDU-A nrPDB 161 5e-40 5EFQ-A nrPDB 159 2e-39 4NST-A nrPDB 157 5e-39 3EB0-A nrPDB 157 5e-39 5AIR-A nrPDB 157 7e-39 4E7W-A nrPDB 155 2e-38 4BGQ-A nrPDB 154 5e-38 3MIA-A nrPDB 151 4e-37 2W96-B nrPDB 149 2e-36 3GC0-A nrPDB 148 4e-36 5Y86-A nrPDB 144 7e-35 3E3P-A nrPDB 143 9e-35 5ZTN-A nrPDB 139 1e-33 5XVU-A nrPDB 137 1e-32 6O6Q-A nrPDB 135 4e-32 4CRL-A nrPDB 130 9e-31 6HMD-A nrPDB 127 1e-29 5X8I-B nrPDB 126 2e-29 4RGJ-A nrPDB 126 2e-29 3LIJ-A nrPDB 124 7e-29 3NCG-A nrPDB 124 8e-29 3DFA-A nrPDB 123 1e-28 3MA6-A nrPDB 120 9e-28 6EII-A nrPDB 120 9e-28 5JN2-A nrPDB 120 1e-27 4LFI-A nrPDB 119 1e-27 4MD7-E nrPDB 119 2e-27 3IS5-A nrPDB 119 3e-27 2PVN-A nrPDB 117 8e-27 2YCR-A nrPDB 115 3e-26 6FYV-A nrPDB 115 3e-26 3DXN-A nrPDB 114 5e-26 3HZT-A nrPDB 114 8e-26 3I6U-A nrPDB 113 2e-25 4IAN-A nrPDB 111 6e-25 3Q5I-A nrPDB 107 9e-24 3H4J-B nrPDB 106 2e-23 5UNP-A nrPDB 105 3e-23 4YZB-A nrPDB 105 3e-23 4MVF-A nrPDB 105 3e-23 5XZW-A nrPDB 103 1e-22 3GUB-A nrPDB 103 2e-22 4APC-A nrPDB 102 3e-22 2WO6-A nrPDB 102 4e-22 1ZWS-A nrPDB 101 5e-22 3RAW-A nrPDB 101 6e-22 4NIF-A nrPDB 101 6e-22 4WNO-A nrPDB 100 7e-22 4PDS-A nrPDB 100 8e-22 3MN3-A nrPDB 100 9e-22 2J90-A nrPDB 100 9e-22 2V7O-A nrPDB 100 1e-21 4FG9-A nrPDB 100 1e-21 6E2O-A nrPDB 100 1e-21 4CFH-A nrPDB 100 1e-21 2A27-A nrPDB 100 2e-21 4B6L-A nrPDB 100 2e-21 3F3Z-A nrPDB 99 2e-21 4REW-A nrPDB 99 3e-21 3HKO-A nrPDB 99 3e-21 2JC6-A nrPDB 99 3e-21 4KS7-A nrPDB 98 4e-21 2YAB-A nrPDB 98 4e-21 4KIK-B nrPDB 98 5e-21 5JZN-A nrPDB 98 5e-21 4FIE-A nrPDB 98 5e-21 4XBR-A nrPDB 98 6e-21 6QAU-A nrPDB 98 6e-21 2Z7Q-A nrPDB 98 7e-21 2Q0N-A nrPDB 97 7e-21 4JDH-A nrPDB 97 7e-21 2F57-A nrPDB 97 9e-21 6FD3-A nrPDB 97 9e-21 5FG8-A nrPDB 97 1e-20 4JG6-A nrPDB 97 1e-20 2X4F-A nrPDB 97 1e-20 3BHH-A nrPDB 97 1e-20 4RED-A nrPDB 97 1e-20 2VN9-A nrPDB 97 2e-20 5D9K-A nrPDB 96 2e-20 3Q53-A nrPDB 96 2e-20 4UZD-A nrPDB 96 2e-20 5KZ7-A nrPDB 96 2e-20 2QNJ-A nrPDB 96 3e-20 2VZ6-A nrPDB 96 3e-20 5U6Y-A nrPDB 95 4e-20 5ES1-A nrPDB 95 4e-20 1S9I-A nrPDB 95 4e-20 3KK8-A nrPDB 95 4e-20 6C9D-A nrPDB 95 5e-20 4I6B-A nrPDB 95 5e-20 2HAK-A nrPDB 95 5e-20 2BDW-A nrPDB 95 5e-20 4WB7-A nrPDB 95 6e-20 4C0T-A nrPDB 94 6e-20 5TQX-A nrPDB 94 8e-20 6CMJ-A nrPDB 94 8e-20 3DTC-A nrPDB 94 9e-20 1FOT-A nrPDB 94 1e-19 5X3F-B nrPDB 94 1e-19 5DYK-A nrPDB 93 2e-19 3D2K-A nrPDB 93 2e-19 5FET-A nrPDB 93 2e-19 3SOA-A nrPDB 93 2e-19 3QA8-A nrPDB 93 2e-19 4EQM-A nrPDB 93 2e-19 4UY9-A nrPDB 93 2e-19 2JDO-A nrPDB 93 2e-19 4JXF-A nrPDB 92 3e-19 3COM-A nrPDB 91 5e-19 2WTK-C nrPDB 91 5e-19 2OU7-A nrPDB 91 5e-19 5F9E-A nrPDB 91 6e-19 4CQG-A nrPDB 91 7e-19 4J52-A nrPDB 91 8e-19 5IG1-A nrPDB 91 8e-19 4YNZ-A nrPDB 91 9e-19 2JAM-A nrPDB 91 1e-18 4D2V-A nrPDB 90 1e-18 5KKR-C nrPDB 90 1e-18 4OW8-A nrPDB 90 1e-18 3KN6-A nrPDB 90 2e-18 4L42-A nrPDB 90 2e-18 3EQC-A nrPDB 89 2e-18 6B2Q-A nrPDB 89 2e-18 4D28-A nrPDB 89 2e-18 3DLS-A nrPDB 89 2e-18 4X3F-A nrPDB 89 2e-18 1KOA-A nrPDB 89 3e-18 4AN9-A nrPDB 89 3e-18 3UTO-A nrPDB 89 3e-18 6CCF-A nrPDB 89 4e-18 5N23-A nrPDB 89 4e-18 2Y7J-A nrPDB 89 4e-18 4CFF-A nrPDB 88 5e-18 5YV8-A nrPDB 88 5e-18 3ORZ-A nrPDB 88 5e-18 2XNP-A nrPDB 88 5e-18 4RLP-A nrPDB 88 6e-18 6BDL-A nrPDB 88 6e-18 4UYA-A nrPDB 88 6e-18 5EZV-A nrPDB 88 7e-18 1U5R-A nrPDB 88 7e-18 6FDY-U nrPDB 88 7e-18 2GCD-A nrPDB 88 7e-18 5KCV-A nrPDB 87 9e-18 1KOB-A nrPDB 87 1e-17 3MV5-A nrPDB 87 1e-17 4CSV-A nrPDB 87 1e-17 4LG4-A nrPDB 87 1e-17 6AO5-A nrPDB 87 1e-17 5SYS-A nrPDB 86 2e-17 2YZA-A nrPDB 86 2e-17 2HW6-A nrPDB 86 2e-17 1PHK-A nrPDB 86 3e-17 4XEY-B nrPDB 86 3e-17 2H8H-A nrPDB 86 3e-17 6F3F-A nrPDB 86 3e-17 5YKS-A nrPDB 86 3e-17 3DB8-A nrPDB 86 3e-17 4CZT-A nrPDB 85 4e-17 2PL0-A nrPDB 85 4e-17 5D7A-A nrPDB 85 4e-17 3A4O-X nrPDB 85 6e-17 1ZXE-A nrPDB 84 7e-17 4AF3-A nrPDB 84 1e-16 2FO0-A nrPDB 84 1e-16 5WAX-A nrPDB 84 1e-16 6NPU-A nrPDB 84 1e-16 2DQ7-X nrPDB 84 1e-16 4FR4-A nrPDB 83 1e-16 3HDN-A nrPDB 83 2e-16 2XYN-A nrPDB 83 2e-16 2HK5-A nrPDB 83 2e-16 4U41-A nrPDB 83 2e-16 3UC3-A nrPDB 83 2e-16 5EG3-A nrPDB 82 4e-16 2BRG-A nrPDB 82 4e-16 5VO2-A nrPDB 82 4e-16 2PSQ-A nrPDB 82 5e-16 2W4O-A nrPDB 81 5e-16 5J5T-A nrPDB 81 6e-16 6CQF-A nrPDB 81 7e-16 3DAK-A nrPDB 81 7e-16 3LM0-A nrPDB 81 8e-16 3GQL-A nrPDB 81 8e-16 5H2U-A nrPDB 81 8e-16 5LOH-A nrPDB 80 9e-16 4QMW-A nrPDB 80 1e-15 4TNB-A nrPDB 80 1e-15 3CJF-A nrPDB 80 2e-15 1AD5-A nrPDB 80 2e-15 3UDB-A nrPDB 80 2e-15 3ZUT-A nrPDB 80 2e-15 5A46-A nrPDB 80 2e-15 2UV2-A nrPDB 80 2e-15 5O0Y-A nrPDB 79 2e-15 6CKI-A nrPDB 79 3e-15 2W1I-A nrPDB 79 3e-15 3A8W-A nrPDB 79 3e-15 3TT0-A nrPDB 79 3e-15 3IO7-A nrPDB 79 4e-15 4XCU-A nrPDB 78 5e-15 4K33-A nrPDB 78 5e-15 2WQN-A nrPDB 78 7e-15 3LLT-A nrPDB 77 8e-15 6E9W-A nrPDB 77 9e-15 2XIK-A nrPDB 77 1e-14 5HVK-A nrPDB 77 1e-14 3VN9-A nrPDB 77 1e-14 4B8L-A nrPDB 77 1e-14 2JD5-A nrPDB 77 2e-14 6GQK-A nrPDB 77 2e-14 3TAC-A nrPDB 76 2e-14 3FME-A nrPDB 76 2e-14 4FZF-B nrPDB 76 2e-14 5HI2-A nrPDB 76 2e-14 4WUA-A nrPDB 76 2e-14 5DBX-A nrPDB 76 3e-14 3NYO-A nrPDB 76 3e-14 6ED6-A nrPDB 75 3e-14 5L6P-A nrPDB 75 6e-14 4GS6-A nrPDB 74 7e-14 1VZO-A nrPDB 74 8e-14 3PLS-A nrPDB 74 8e-14 5O2C-A nrPDB 74 9e-14 4M7I-A nrPDB 74 1e-13 1JPA-A nrPDB 74 1e-13 5GRN-A nrPDB 74 1e-13 5O2B-A nrPDB 74 1e-13 2A1A-B nrPDB 73 2e-13 5HIE-A nrPDB 73 2e-13 4E93-A nrPDB 73 2e-13 3TXO-A nrPDB 73 2e-13 6CTH-A nrPDB 72 3e-13 3PPZ-A nrPDB 72 3e-13 4NEU-A nrPDB 72 3e-13 1TKI-A nrPDB 72 3e-13 3ALO-A nrPDB 72 4e-13 5X5O-A nrPDB 72 4e-13 4HVI-A nrPDB 72 4e-13 5UUU-A nrPDB 72 4e-13 5MJB-A nrPDB 72 4e-13 4RC3-A nrPDB 72 4e-13 5TUR-A nrPDB 72 5e-13 3PVW-A nrPDB 72 5e-13 3BGP-A nrPDB 71 6e-13 6DBN-A nrPDB 71 7e-13 3ORP-A nrPDB 71 7e-13 4RA4-A nrPDB 70 1e-12 5X02-A nrPDB 70 1e-12 6HXF-B nrPDB 70 1e-12 2R2P-A nrPDB 70 1e-12 2I0E-A nrPDB 70 1e-12 3UIU-A nrPDB 70 1e-12 3PFQ-A nrPDB 70 1e-12 4XUF-A nrPDB 70 1e-12 4P5Q-A nrPDB 70 2e-12 6HV0-A nrPDB 69 2e-12 5VD3-A nrPDB 69 3e-12 4XI2-A nrPDB 69 3e-12 6E4F-A nrPDB 69 3e-12 5TOS-A nrPDB 69 3e-12 2RIO-A nrPDB 69 5e-12 3G0E-A nrPDB 68 5e-12 1NY3-A nrPDB 68 5e-12 2H34-A nrPDB 68 5e-12 3C51-A nrPDB 68 5e-12 2OZA-A nrPDB 68 6e-12 3KA0-A nrPDB 68 6e-12 1K9A-A nrPDB 68 6e-12 5HLW-A nrPDB 68 6e-12 3BEA-A nrPDB 68 7e-12 1BYG-A nrPDB 68 7e-12 4PWN-A nrPDB 68 7e-12 3OMV-A nrPDB 67 8e-12 4Y93-A nrPDB 67 9e-12 2Y6O-A nrPDB 67 9e-12 4YHJ-A nrPDB 67 1e-11 4OTD-A nrPDB 67 1e-11 3DKO-A nrPDB 67 1e-11 4PL5-B nrPDB 67 1e-11 3TKU-A nrPDB 67 2e-11 2OGV-A nrPDB 67 2e-11 3FXW-A nrPDB 66 2e-11 6BXI-A nrPDB 66 2e-11 2X7G-A nrPDB 66 2e-11 4IDT-A nrPDB 66 2e-11 2VWV-A nrPDB 66 2e-11 4CRS-A nrPDB 66 2e-11 3SXS-A nrPDB 66 3e-11 5XD6-A nrPDB 65 3e-11 3C1X-A nrPDB 65 3e-11 5B2L-A nrPDB 65 3e-11 4Y83-A nrPDB 65 4e-11 2PMN-X nrPDB 65 4e-11 4F9B-A nrPDB 65 4e-11 4EBW-A nrPDB 65 4e-11 5AMN-A nrPDB 65 5e-11 3KRL-A nrPDB 65 5e-11 5U6B-A nrPDB 65 5e-11 5UIU-A nrPDB 65 6e-11 2J0K-A nrPDB 65 7e-11 5LPZ-A nrPDB 64 7e-11 4TPT-A nrPDB 64 7e-11 5LPV-A nrPDB 64 1e-10 4PDO-A nrPDB 64 1e-10 3KUL-B nrPDB 64 1e-10 4AT3-A nrPDB 64 1e-10 4BTK-A nrPDB 64 1e-10 4NFN-A nrPDB 63 2e-10 1FVR-A nrPDB 63 2e-10 3V5Q-A nrPDB 63 2e-10 3QD2-B nrPDB 62 3e-10 4G3E-A nrPDB 62 5e-10 6DBM-A nrPDB 61 6e-10 2BUJ-A nrPDB 61 6e-10 4R7H-A nrPDB 61 1e-09 4M66-A nrPDB 60 1e-09 5L2Q-C nrPDB 60 1e-09 3QGY-A nrPDB 60 1e-09 4AW2-A nrPDB 60 2e-09 4X7Q-B nrPDB 60 2e-09 6FER-A nrPDB 60 2e-09 5WNO-A nrPDB 60 2e-09 5FM2-A nrPDB 60 2e-09 3PP0-A nrPDB 59 3e-09 3QUP-A nrPDB 59 3e-09 3LZB-A nrPDB 59 3e-09 4YFF-A nrPDB 59 3e-09 4OLI-A nrPDB 59 3e-09 6J5U-C nrPDB 59 3e-09 5FQD-C nrPDB 59 4e-09 3HNG-A nrPDB 58 5e-09 4JLC-A nrPDB 58 6e-09 3VHK-A nrPDB 58 6e-09 5KMM-A nrPDB 58 6e-09 4E20-A nrPDB 58 8e-09 6FEX-A nrPDB 57 9e-09 6GVJ-A nrPDB 57 9e-09 3Q4U-A nrPDB 57 1e-08 5GNK-A nrPDB 57 1e-08 1U59-A nrPDB 57 2e-08 3M42-A nrPDB 57 2e-08 5U6C-A nrPDB 57 2e-08 4FL3-A nrPDB 57 2e-08 4EUT-A nrPDB 57 2e-08 3HMP-A nrPDB 57 2e-08 4EUU-A nrPDB 56 2e-08 4C59-A nrPDB 56 2e-08 6NT9-A nrPDB 56 2e-08 3SOC-A nrPDB 56 2e-08 2OZO-A nrPDB 56 2e-08 5C26-A nrPDB 56 3e-08 3BBT-B nrPDB 56 3e-08 5AP3-A nrPDB 56 3e-08 6BSD-A nrPDB 55 3e-08 4F0G-A nrPDB 55 4e-08 2ZMD-A nrPDB 55 5e-08 6O8B-A nrPDB 55 5e-08 2QLU-A nrPDB 55 5e-08 4LRM-A nrPDB 54 7e-08 2QKW-B nrPDB 54 8e-08 3UIM-A nrPDB 54 8e-08 3ZBF-A nrPDB 54 8e-08 2VD5-A nrPDB 54 9e-08 3MDY-A nrPDB 54 9e-08 4XLV-A nrPDB 54 1e-07 4LQP-A nrPDB 53 2e-07 5J0A-A nrPDB 53 2e-07 5VC6-A nrPDB 53 2e-07 4TN6-A nrPDB 53 2e-07 5IKW-A nrPDB 53 2e-07 1LUF-A nrPDB 53 2e-07 4RT7-A nrPDB 53 2e-07 5E8V-A nrPDB 53 3e-07 4Y12-A nrPDB 52 3e-07 2WTK-B nrPDB 52 3e-07 2PZI-A nrPDB 52 4e-07 4HZS-A nrPDB 51 7e-07 1U54-B nrPDB 51 7e-07 4H1J-A nrPDB 51 8e-07 5TE0-A nrPDB 51 9e-07 3I81-A nrPDB 51 9e-07 3SV0-A nrPDB 50 1e-06 3ZZW-A nrPDB 49 2e-06 3MY0-A nrPDB 49 3e-06 2CMW-A nrPDB 49 4e-06 3G2F-A nrPDB 49 5e-06 2C47-A nrPDB 48 6e-06 5X1R-A nrPDB 47 1e-05 5CLR-A nrPDB 47 1e-05 4M69-B nrPDB 47 1e-05 2Y4I-B nrPDB 47 1e-05 5CEK-A nrPDB 47 1e-05 6DC0-A nrPDB 47 2e-05 2CHL-A nrPDB 47 2e-05 4BTF-A nrPDB 46 2e-05 1PY5-A nrPDB 46 2e-05 4XHH-A nrPDB 45 4e-05 4XHL-A nrPDB 44 9e-05 4JRN-A nrPDB 44 1e-04 3LMG-A nrPDB 44 1e-04 4L68-A nrPDB 44 1e-04 5WNL-A nrPDB 44 1e-04 4IX6-A nrPDB 43 3e-04 4CI6-B nrPDB 42 3e-04 4NT4-A nrPDB 42 4e-04 5AR8-A nrPDB 41 8e-04 5VDK-A nrPDB 40 0.001 5X18-A nrPDB 40 0.002 4MWI-A nrPDB 39 0.002 1CSN-A nrPDB 39 0.004 6BFN-A nrPDB 39 0.005 2RSV-A nrPDB 37 0.009 2LAV-A nrPDB 37 0.011 3ENH-A nrPDB 34 0.099 5OAT-A nrPDB 33 0.16 5UU1-A nrPDB 33 0.20 5UV4-A nrPDB 33 0.27 6EQI-C nrPDB 32 0.29 5M07-A nrPDB 32 0.41 5VE6-A nrPDB 30 1.1 6EWX-A nrPDB 30 1.1 6J6I-B nrPDB 28 4.9 6G4J-A nrPDB 28 6.2 >4EWQ-A nrPDB Length = 383 Score = 749 bits (1935), Expect = 0.0, Method: Compositional matrix adjust. Identities = 359/359 (100%), Positives = 359/359 (100%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS Sbjct: 25 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 84 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK Sbjct: 85 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 144 Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG 181 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG Sbjct: 145 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG 204 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGT 241 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGT Sbjct: 205 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGT 264 Query: 242 PGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQ 301 PGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQ Sbjct: 265 PGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQ 324 Query: 302 ALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES 360 ALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES Sbjct: 325 ALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES 383 >3OHT-A nrPDB Length = 389 Score = 661 bits (1706), Expect = 0.0, Method: Compositional matrix adjust. Identities = 309/358 (86%), Positives = 333/358 (93%) Query: 3 QERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSI 62 +ERPTFYRQELNKTIWEVPERYQ LSPVGSGAYGSVC+++D K+GL++AVKKLSRPFQSI Sbjct: 32 KERPTFYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSI 91 Query: 63 IHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL 122 IHAKRTYRELRLLKHMKHENVIGLLDVFTPA SLEEFNDVYLVTHLMGADLNNIVKCQKL Sbjct: 92 IHAKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKL 151 Query: 123 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY 182 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY Sbjct: 152 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY 211 Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 242 VATRWYRAPEIMLNWMHYN TVDIWSVGCIMAELLTGRTLFPGTDHI+QL+ I+RL GTP Sbjct: 212 VATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTP 271 Query: 243 GAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQA 302 A ++ ++ S ARNYI SL QMPK NFA+VFIGANPLAVDLLEKMLVLD+DKRITA++A Sbjct: 272 PASVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEA 331 Query: 303 LAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES 360 LAH YF+QYHDPDDEP ++PYDQSFESR L I+EWK LTY+EV SF PP D +EMES Sbjct: 332 LAHPYFSQYHDPDDEPESEPYDQSFESRQLEIEEWKRLTYEEVCSFETPPFDGDEMES 389 >3GC9-A nrPDB Length = 370 Score = 570 bits (1470), Expect = e-163, Method: Compositional matrix adjust. Identities = 261/348 (75%), Positives = 308/348 (88%) Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60 MS R FYRQELNKT+WEVP+R Q L PVGSGAYGSVC+A+D + +VAVKKLSRPFQ Sbjct: 7 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 66 Query: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120 S+IHA+RTYRELRLLKH+KHENVIGLLDVFTPA S+E+F++VYLVT LMGADLNNIVK Q Sbjct: 67 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQ 126 Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180 L+D+HVQFL+YQ+LRGLKYIHSA IIHRDLKPSN+AVNED EL+ILDFGLAR D+EMT Sbjct: 127 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMT 186 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL G+ LFPG+D+IDQLK I+ +VG Sbjct: 187 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 246 Query: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300 TP E+L KISSE AR YIQSL MP+ + +++F GANPLA+DLL +MLVLDSD+R++AA Sbjct: 247 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 306 Query: 301 QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISF 348 +ALAHAYF+QYHDP+DEP A+PYD+S E+++ ++EWK LTY EV+SF Sbjct: 307 EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSF 354 >1CM8-A nrPDB Length = 367 Score = 491 bits (1265), Expect = e-139, Method: Compositional matrix adjust. Identities = 221/347 (63%), Positives = 279/347 (80%) Query: 5 RPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH 64 R FYRQE+ KT WEV Y++L PVGSGAYG+VC+A D +TG +VA+KKL RPFQS + Sbjct: 8 RSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELF 67 Query: 65 AKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTD 124 AKR YRELRLLKHM+HENVIGLLDVFTP +L++F D YLV MG DL ++K +KL + Sbjct: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE 127 Query: 125 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVA 184 D +QFL+YQ+L+GL+YIH+A IIHRDLKP NLAVNEDCELKILDFGLAR D EMTGYV Sbjct: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV 187 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGA 244 TRWYRAPE++LNWM Y QTVDIWSVGCIMAE++TG+TLF G+DH+DQLK I+++ GTP A Sbjct: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247 Query: 245 ELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304 E ++++ S+ A+NY++ L ++ K +FA++ A+PLAV+LLEKMLVLD+++R+TA +ALA Sbjct: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 Query: 305 HAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPP 351 H YF HD +DEP YD SF+ D +DEWK +TY EV+SF PP Sbjct: 308 HPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354 >4MYG-A nrPDB Length = 372 Score = 464 bits (1194), Expect = e-131, Method: Compositional matrix adjust. Identities = 214/347 (61%), Positives = 271/347 (78%), Gaps = 2/347 (0%) Query: 5 RPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH 64 + FY+Q++NKT WE+P+ Y + + VGSGAYGSVC+A D ++G +VA+KKLSRPFQS I Sbjct: 26 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 85 Query: 65 AKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTD 124 AKR YREL LLKHM+HENVIGLLDVFTPA SL F D YLV M DL I+ + ++ Sbjct: 86 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSE 144 Query: 125 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVA 184 + +Q+L+YQ+L+GLKYIHSA ++HRDLKP NLAVNEDCELKILDFGLARH D EMTGYV Sbjct: 145 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV 204 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGA 244 TRWYRAPE++L+WMHYNQTVDIWSVGCIMAE+LTG+TLF G D++DQL IL++ G PG Sbjct: 205 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 264 Query: 245 ELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304 E ++K++ ++A++YIQSL Q P+ +F +F A+P A DLLEKML LD DKR+TAAQAL Sbjct: 265 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 324 Query: 305 HAYFAQYHDPDDEPVA-DPYDQSFESRDLLIDEWKSLTYDEVISFVP 350 H +F + DP++E A P+D S E L +DEWK Y E+++F P Sbjct: 325 HPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 371 >3E7O-A nrPDB Length = 360 Score = 339 bits (869), Expect = 1e-93, Method: Compositional matrix adjust. Identities = 177/355 (49%), Positives = 231/355 (65%), Gaps = 19/355 (5%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR Sbjct: 8 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 67 Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ + L + + Sbjct: 68 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERM 126 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T Sbjct: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVT 186 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 R+YRAPE++L M Y + VDIWSVGCIM EL+ G +F GTDHIDQ ++ +GTP AE Sbjct: 187 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAE 245 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIG------------ANPLAVDLLEKMLVLDS 293 + + + RNY+++ P + F +F A DLL KMLV+D Sbjct: 246 FMAALQP-TVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 304 Query: 294 DKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVI 346 DKRI+ +AL H Y ++DP + P YD E R+ I+EWK L Y EV+ Sbjct: 305 DKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVM 359 >5AWM-A nrPDB Length = 394 Score = 333 bits (854), Expect = 6e-92, Method: Compositional matrix adjust. Identities = 173/365 (47%), Positives = 239/365 (65%), Gaps = 20/365 (5%) Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60 M+ + Y E+ T + + RY NL P+GSGA G VCAA+DT T VA+KKLSRPFQ Sbjct: 23 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ 82 Query: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120 ++ HAKR YRE +L+K + H+N+IGLL+ FTP R+LEEF DVYLV LM A+L +++ Sbjct: 83 NVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ-M 141 Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDE 178 L D + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T Sbjct: 142 DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM 201 Query: 179 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL 238 MT YV TR+YRAPE++L M Y + VDIWSVGCIM E++ G LFPGTDHIDQ I+ Sbjct: 202 MTPYVVTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 260 Query: 239 VGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFI-GANPL------------AVDLL 285 +GTP ++++ + RNY+++ + +F +F G P A +LL Sbjct: 261 LGTPSPSFMQRLQP-TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLL 319 Query: 286 EKMLVLDSDKRITAAQALAHAYFAQYHDPD--DEPVADPYDQSFESRDLLIDEWKSLTYD 343 KMLV+D ++RI+ +AL H Y ++D + D P +PYD S + R+ +++WK L Y+ Sbjct: 320 SKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYE 379 Query: 344 EVISF 348 EV+ + Sbjct: 380 EVMDY 384 >5NGU-A nrPDB Length = 381 Score = 333 bits (854), Expect = 7e-92, Method: Compositional matrix adjust. Identities = 167/341 (48%), Positives = 233/341 (68%), Gaps = 9/341 (2%) Query: 17 IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 +++V RY NLS +G GAYG VC+A+D +RVA+KK+S PF+ + +RT RE+++L Sbjct: 37 VFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLREIKILL 95 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILR 136 +HEN+IG+ D+ A ++E+ DVY+V LM DL ++K Q L++DH+ + +YQILR Sbjct: 96 RFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILR 154 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRA 190 GLKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D + +T YVATRWYRA Sbjct: 155 GLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRA 214 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250 PEIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P E L I Sbjct: 215 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 274 Query: 251 SSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 + ARNY+ SL K+ + +F A+ A+DLL+KML + KRI QALAH Y Q Sbjct: 275 INLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 334 Query: 311 YHDPDDEPVAD-PYDQSFESRDLLIDEWKSLTYDEVISFVP 350 Y+DP DEP+A+ P+ E DL ++ K L ++E F P Sbjct: 335 YYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQP 375 >4QTB-A nrPDB Length = 380 Score = 332 bits (850), Expect = 2e-91, Method: Compositional matrix adjust. Identities = 169/344 (49%), Positives = 233/344 (67%), Gaps = 9/344 (2%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 ++V RY L +G GAYG V +A+D RVA+KK+S PF+ + +RT RE+++L Sbjct: 37 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 95 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 137 +HENVIG+ D+ A +LE DVY+V LM DL ++K Q+L++DH+ + +YQILRG Sbjct: 96 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 154 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRAP 191 LKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D E +T YVATRWYRAP Sbjct: 155 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 214 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 EIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P E L I Sbjct: 215 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 274 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311 + ARNY+QSL K+ +A +F ++ A+DLL++ML + +KRIT +ALAH Y QY Sbjct: 275 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 334 Query: 312 HDPDDEPVA-DPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLD 354 +DP DEPVA +P+ + E DL + K L + E F P L+ Sbjct: 335 YDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLE 378 >2XS0-A nrPDB Length = 386 Score = 330 bits (847), Expect = 5e-91, Method: Compositional matrix adjust. Identities = 173/361 (47%), Positives = 234/361 (64%), Gaps = 19/361 (5%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ Sbjct: 6 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 65 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V LM A+L +++ + Sbjct: 66 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME- 124 Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179 L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T M Sbjct: 125 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 184 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239 +V TR+YRAPE++L M Y + VDIWSVGCIM E++ G LFPGTDHIDQ ++ + Sbjct: 185 VPFVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 243 Query: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLEK 287 GTP E +KK+ + R Y+++ + +F +F N L A DLL K Sbjct: 244 GTPCPEFMKKLQP-TVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 302 Query: 288 MLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPY--DQSFESRDLLIDEWKSLTYDEV 345 MLV+D+ KRI+ +AL H Y ++DP + P D+ + R+ I+EWK L Y EV Sbjct: 303 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 362 Query: 346 I 346 + Sbjct: 363 M 363 >1JNK-A nrPDB Length = 423 Score = 327 bits (838), Expect = 4e-90, Method: Compositional matrix adjust. Identities = 172/356 (48%), Positives = 233/356 (65%), Gaps = 19/356 (5%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ HAKR Sbjct: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV LM A+L +++ + L + + Sbjct: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 166 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV T Sbjct: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 R+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG D+IDQ ++ +GTP E Sbjct: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLEKMLVLDS 293 +KK+ + RNY+++ + + F +F + N L A DLL KMLV+D Sbjct: 286 FMKKLQP-TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 Query: 294 DKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVIS 347 KRI+ AL H Y ++DP + P YD+ + R+ I+EWK L Y EV++ Sbjct: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 >6DTL-A nrPDB Length = 364 Score = 323 bits (827), Expect = 9e-89, Method: Compositional matrix adjust. Identities = 163/348 (46%), Positives = 231/348 (66%), Gaps = 7/348 (2%) Query: 8 FYRQELNKTIWEVPERYQN-LSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK 66 F + + I+EV +Y+ + P+G GAYG VC+A +++T VA+KK++ F + I AK Sbjct: 15 FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK 74 Query: 67 RTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-QKLTDD 125 RT RE++LL+HM HEN++ + D+ P FNDVY+ LM DL+ I++ Q L+++ Sbjct: 75 RTLREIKLLRHMDHENIVAIRDIIPPPLR-NAFNDVYIAYELMDTDLHQIIRSNQALSEE 133 Query: 126 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD--DEMTGYV 183 H Q+ +YQILRGLKYIHSA+++HRDLKPSNL +N +C+LKI DFGLAR T D MT YV Sbjct: 134 HCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYV 193 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPG 243 TRWYRAPE++LN Y +D+WSVGCI EL+ + LFPG DH+ QL+L++ L+GTP Sbjct: 194 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP- 252 Query: 244 AELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQAL 303 +E + +E+A+ YI+ L P+ + + F +PLA+DL+EKML D +RIT AL Sbjct: 253 SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 312 Query: 304 AHAYFAQYHDPDDEP-VADPYDQSFESRDLLIDEWKSLTYDEVISFVP 350 AH Y HD DEP P++ FE+ L ++ K L Y E ++F P Sbjct: 313 AHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNP 360 >4IC8-A nrPDB Length = 442 Score = 317 bits (812), Expect = 5e-87, Method: Compositional matrix adjust. Identities = 158/340 (46%), Positives = 222/340 (65%), Gaps = 9/340 (2%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 ++V + Y+ + +G+GAYG V +A TG +VA+KK+ F + +AKRT REL++LKH Sbjct: 51 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 110 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQKLTDDHVQFLIYQILR 136 KH+N+I + D+ P EF VY+V LM +DL+ I+ Q LT +HV++ +YQ+LR Sbjct: 111 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 170 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYR 189 GLKY+HSA +IHRDLKPSNL VNE+CELKI DFG+AR MT YVATRWYR Sbjct: 171 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 230 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 APE+ML+ Y Q +D+WSVGCI E+L R LFPG +++ QL+LI+ ++GTP +++ Sbjct: 231 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 290 Query: 250 ISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 + +E R YIQSL + + V+ GA+ A+ LL +ML + RI+AA AL H + A Sbjct: 291 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 350 Query: 310 QYHDPDDEP-VADPYDQSFESRDLLIDEWKSLTYDEVISF 348 +YHDPDDEP A P+D +F+ L + K E+ F Sbjct: 351 KYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 390 >4ZSG-A nrPDB Length = 347 Score = 316 bits (810), Expect = 8e-87, Method: Compositional matrix adjust. Identities = 158/340 (46%), Positives = 222/340 (65%), Gaps = 9/340 (2%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 ++V + Y+ + +G+GAYG V +A TG +VA+KK+ F + +AKRT REL++LKH Sbjct: 3 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 62 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQKLTDDHVQFLIYQILR 136 KH+N+I + D+ P EF VY+V LM +DL+ I+ Q LT +HV++ +YQ+LR Sbjct: 63 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 122 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYR 189 GLKY+HSA +IHRDLKPSNL VNE+CELKI DFG+AR MT YVATRWYR Sbjct: 123 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 182 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 APE+ML+ Y Q +D+WSVGCI E+L R LFPG +++ QL+LI+ ++GTP +++ Sbjct: 183 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 242 Query: 250 ISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 + +E R YIQSL + + V+ GA+ A+ LL +ML + RI+AA AL H + A Sbjct: 243 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 302 Query: 310 QYHDPDDEP-VADPYDQSFESRDLLIDEWKSLTYDEVISF 348 +YHDPDDEP A P+D +F+ L + K E+ F Sbjct: 303 KYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 342 >2F9G-A nrPDB Length = 353 Score = 313 bits (801), Expect = 1e-85, Method: Compositional matrix adjust. Identities = 158/352 (44%), Positives = 219/352 (62%), Gaps = 21/352 (5%) Query: 15 KTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRL 74 + ++ + +Q S +G GAYG VC+A TG VA+KK+ PF + A RT RE+++ Sbjct: 4 RIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKI 62 Query: 75 LKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQI 134 LKH KHEN+I + ++ P S E FN+VY++ LM DL+ ++ Q L+DDH+Q+ IYQ Sbjct: 63 LKHFKHENIITIFNIQRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQT 121 Query: 135 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------------MTG 181 LR +K +H +++IHRDLKPSNL +N +C+LK+ DFGLAR D+ MT Sbjct: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGT 241 YVATRWYRAPE+ML Y++ +D+WS GCI+AEL R +FPG D+ QL LI ++GT Sbjct: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 Query: 242 PGAEL-LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300 P ++ L+ I S AR YI+SL P +F NP +DLL++MLV D KRITA Sbjct: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 Query: 301 QALAHAYFAQYHDPDDEPVADPYDQSFESRD-----LLIDEWKSLTYDEVIS 347 +AL H Y YHDP+DEP +P SF D L + K L ++E+ S Sbjct: 302 EALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 >3FI2-A nrPDB Length = 353 Score = 310 bits (794), Expect = 5e-85, Method: Compositional matrix adjust. Identities = 167/354 (47%), Positives = 226/354 (63%), Gaps = 26/354 (7%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ HAKR Sbjct: 10 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 69 Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV LM A+L +++ + L + + Sbjct: 70 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 128 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV T Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 188 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 R+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG D+IDQ ++ +GTP E Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 247 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLEKMLVLDS 293 +KK+ + RNY+++ + + F +F + N L A DLL KMLV+D Sbjct: 248 FMKKLQP-TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 306 Query: 294 DKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVIS 347 KRI+ AL H Y ++ + R+ I+EWK L Y EV++ Sbjct: 307 AKRISVDDALQHPYINVWYX---------XXXXXDEREHTIEEWKELIYKEVMN 351 >5Z33-A nrPDB Length = 425 Score = 303 bits (776), Expect = 7e-83, Method: Compositional matrix adjust. Identities = 166/339 (48%), Positives = 212/339 (62%), Gaps = 13/339 (3%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 V ERY +G GAYG VCAA + +T VA+KK++ F I AKR RE++LL+H + Sbjct: 29 VDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFR 88 Query: 80 -HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQILRG 137 H N+ L D+ P + FN+ YL LM DL I++ Q LTD H Q IYQIL G Sbjct: 89 GHRNITCLYDMDIP--RPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCG 146 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDE-----MTGYVATRWYRA 190 LKYIHSA+++HRDLKP NL VN DCELKI DFGLAR D E MT YVATRWYRA Sbjct: 147 LKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRA 206 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250 PEIML++ Y + +D+WSVGCI+AELL GR F G D++DQL IL ++GTP E L +I Sbjct: 207 PEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRI 266 Query: 251 SSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 S A+ Y+++L M K F +F ANP A+DLL++ML D RI+ QAL H Y Sbjct: 267 GSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYLHI 326 Query: 311 YHDPDDEP-VADPYDQSFESRDLLIDEWKSLTYDEVISF 348 +HD DEP ++ FE + + E + + DEV F Sbjct: 327 WHDASDEPDCPTTFNFDFEVVE-DVGEMRKMILDEVYRF 364 >4O2Z-A nrPDB Length = 377 Score = 273 bits (698), Expect = 8e-74, Method: Compositional matrix adjust. Identities = 140/353 (39%), Positives = 212/353 (60%), Gaps = 16/353 (4%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 F ++ + +EVP +Y L +G GAYG C+ D TG +V++KK F+ + KR Sbjct: 31 FKVYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKR 90 Query: 68 TYRELRLLKHMKHENVIGLLDVFTP-ARSLEEFNDVYLVTHLMGADLNNIVKC-QKLTDD 125 RE+ +++ HEN++ ++++ P R F DVY+VT LM D+N +++ Q L + Sbjct: 91 VLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQVLEES 150 Query: 126 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD---DEMTGY 182 H+Q+ +YQILRGLKY+HSA++ HRDLKP+NL N CELKI+DFGL+R D E+T Y Sbjct: 151 HMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDY 210 Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 242 V TRWYR PE++L +Y+ VDIWSVGCI AE+ + +FPG + +DQL++I + +G P Sbjct: 211 VITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKP 270 Query: 243 GAELLKKISSESARNYIQSLTQMP--KMNFANVFIG--ANPLAVDLLEKMLVLDSDKRIT 298 A +++ R ++ L ++P +N + G N +D L KM LD KR T Sbjct: 271 PASIVEH------REALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPT 324 Query: 299 AAQALAHAYFAQYHDPDDEPVAD-PYDQSFESRDLLIDEWKSLTYDEVISFVP 350 AA LAH Y A HD +DEP P+ + ES + + E + + +++ + P Sbjct: 325 AADMLAHPYLAHLHDEEDEPTCPCPFLWAHESTPMGVSELRRAFWADIVDYNP 377 >4QNY-A nrPDB Length = 354 Score = 262 bits (670), Expect = 1e-70, Method: Compositional matrix adjust. Identities = 135/343 (39%), Positives = 211/343 (61%), Gaps = 7/343 (2%) Query: 12 ELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLR-VAVKKLSRP-FQSIIHAKRTY 69 EL + + +RY +G+G+YG V A DTK+ R VA+K++++ F+ +I AKR Sbjct: 10 ELQAEVCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRIL 69 Query: 70 RELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQ 128 RE++LL H +N+IGL ++ TP E F+ Y+V +M DL +++ Q+LT+ H+Q Sbjct: 70 REIKLLAHFNDDNIIGLRNILTPEDP-ENFDHFYIVMDIMETDLKQVLRSGQELTEAHIQ 128 Query: 129 FLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVAT 185 F IYQ LR L IHSA +IHRD+ P+N+ VN +C+LKI DFGLA+ +D+ MT YV Sbjct: 129 FFIYQALRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTM 188 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 RWYRAPE+++ Y+ +D+W +GCI+ ELL R LF G D ++QL I+ ++GTP E Sbjct: 189 RWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEE 248 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAH 305 + + S +A+ Y++ + P+ ++ + A+P A+DLL MLV + +RIT QA+ H Sbjct: 249 DINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRH 308 Query: 306 AYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISF 348 + Q HD D+ ++ + E+ I + K Y+E + F Sbjct: 309 PFLEQLHDDADDNLSYALFRFDENEQKTIVDVKRAIYEESVKF 351 >3OZ6-A nrPDB Length = 388 Score = 235 bits (599), Expect = 3e-62, Method: Compositional matrix adjust. Identities = 129/372 (34%), Positives = 216/372 (58%), Gaps = 53/372 (14%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 V +Y+ + +G GAYG V + D +TG VAVKK+ FQ+ A+RT+RE+ +L + Sbjct: 7 VLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELS 66 Query: 80 -HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGL 138 HEN++ LL+V + DVYLV M DL+ +++ L H Q+++YQ+++ + Sbjct: 67 GHENIVNLLNVLRA----DNDRDVYLVFDYMETDLHAVIRANILEPVHKQYVVYQLIKVI 122 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---------------------HTDD 177 KY+HS ++HRD+KPSN+ +N +C +K+ DFGL+R + DD Sbjct: 123 KYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDD 182 Query: 178 E---MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKL 234 + +T YVATRWYRAPEI+L Y + +D+WS+GCI+ E+L G+ +FPG+ ++QL+ Sbjct: 183 DQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLER 242 Query: 235 ILRLVGTPGAELLKKISSESARNYIQSLTQMPKM----------NFANVFIGANPL---- 280 I+ ++ P E ++ I S A+ I+SL + ++ + N+ + NP Sbjct: 243 IIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCN 302 Query: 281 --AVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAD-----PYDQSFESRDLL 333 A+DLL+K+L + +KRI+A AL H + + +H+P++EP D P + + + Sbjct: 303 EEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPINDNVKHS--- 359 Query: 334 IDEWKSLTYDEV 345 ID++++L Y E+ Sbjct: 360 IDDYRNLVYSEI 371 >3RP9-A nrPDB Length = 458 Score = 231 bits (588), Expect = 5e-61, Method: Compositional matrix adjust. Identities = 123/355 (34%), Positives = 199/355 (56%), Gaps = 63/355 (17%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 W++P+RY+ +G+G+YG VC A+D VA+KK+ R F+ +I KR RE+ +L Sbjct: 49 WQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNR 108 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ-KLTDDHVQFLIYQILR 136 + H++V+ +LD+ P + +E+F+++Y+V + +D + + LT+ H++ L+Y +L Sbjct: 109 LNHDHVVKVLDIVIP-KDVEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNLLV 167 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR----------------------- 173 G+KY+HSA I+HRDLKP+N VN+DC +K+ DFGLAR Sbjct: 168 GVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNL 227 Query: 174 ----HTDD---EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-------- 218 HT + ++TG+V TRWYRAPE++L +Y + +D+WS+GCI AELL Sbjct: 228 VTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAY 287 Query: 219 ---------GRTLFP-------GTD-------HIDQLKLILRLVGTPGAELLKKISSESA 255 G + FP G D + DQL +I ++GTP E ++ + E A Sbjct: 288 HADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDA 347 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 + YI+ + + A F ++ A+ LL++MLV + +KRIT + LAH +F + Sbjct: 348 KRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKE 402 >3PG1-A nrPDB Length = 362 Score = 220 bits (560), Expect = 8e-58, Method: Compositional matrix adjust. Identities = 124/326 (38%), Positives = 186/326 (57%), Gaps = 38/326 (11%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSI------------IHAKRTYRELRLLKH 77 + SG+YG+VCA D++ G+ VA+K++ F ++ KR RE+RLL H Sbjct: 30 ISSGSYGAVCAGVDSE-GIPVAIKRV---FNTVSDGRTVNILSDSFLCKRVLREIRLLNH 85 Query: 78 MKHENVIGLLDVFTPARSLEE--FNDVYLVTHLMGADLNNIVKCQKL--TDDHVQFLIYQ 133 H N++GL D+F EE + +YLVT LM DL ++ Q++ + H+Q+ +Y Sbjct: 86 FHHPNILGLRDIFV---HFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQHIQYFMYH 142 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVATRWYRAP 191 IL GL +H A ++HRDL P N+ + ++ ++ I DF LAR D T YV RWYRAP Sbjct: 143 ILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYRAP 202 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 E+++ + + + VD+WS GC+MAE+ + LF G+ +QL I+ +VGTP E + S Sbjct: 203 ELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMFS 262 Query: 252 SESARNYIQ-SLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 S SAR+Y++ SL+ +P + V A+P+A+DL+ KML + +RI+ QAL H YF Sbjct: 263 SPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYFES 322 Query: 311 YHDP------------DDEPVADPYD 324 DP DE V D YD Sbjct: 323 LFDPLDLTEGLSERFHFDESVTDVYD 348 >2I6L-A nrPDB Length = 320 Score = 218 bits (555), Expect = 3e-57, Method: Compositional matrix adjust. Identities = 122/324 (37%), Positives = 193/324 (59%), Gaps = 22/324 (6%) Query: 13 LNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKK--LSRPFQSIIHAKRTYR 70 +N +++ RY +L P+G G G V +A D RVA+KK L+ P QS+ HA R Sbjct: 2 MNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDP-QSVKHA---LR 57 Query: 71 ELRLLKHMKHENVIGLLDVFTPARS--------LEEFNDVYLVTHLMGADLNNIVKCQKL 122 E+++++ + H+N++ + ++ P+ S L E N VY+V M DL N+++ L Sbjct: 58 EIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPL 117 Query: 123 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLARHTD----- 176 ++H + +YQ+LRGLKYIHSA+++HRDLKP+NL +N ED LKI DFGLAR D Sbjct: 118 LEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSH 177 Query: 177 -DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLI 235 ++ + T+WYR+P ++L+ +Y + +D+W+ GCI AE+LTG+TLF G ++Q++LI Sbjct: 178 KGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLI 237 Query: 236 LRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDK 295 L + E +++ S YI++ P + G + AVD LE++L Sbjct: 238 LESIPVVHEEDRQELLS-VIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMD 296 Query: 296 RITAAQALAHAYFAQYHDPDDEPV 319 R+TA +AL+H Y + Y P DEP+ Sbjct: 297 RLTAEEALSHPYMSIYSFPMDEPI 320 >3NIE-A nrPDB Length = 429 Score = 205 bits (522), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 126/364 (34%), Positives = 188/364 (51%), Gaps = 58/364 (15%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S R Y Q +VP+ Y+ +G G+YG V A+D VA+KK++R F+ Sbjct: 8 SSGRENLYFQGAIIKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFED 67 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 +I KR RE+ +L +K + +I L D+ P L +F+++Y+V + +DL + K Sbjct: 68 LIDCKRILREITILNRLKSDYIIRLHDLIIP-EDLLKFDELYIVLEIADSDLKKLFKTPI 126 Query: 122 -LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD--- 177 LT+ HV+ ++Y +L G K+IH + IIHRDLKP+N +N+DC +KI DFGLAR + Sbjct: 127 FLTEQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKD 186 Query: 178 -------------------------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCI 212 ++T +V TRWYRAPE++L +Y ++DIWS GCI Sbjct: 187 IHIVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCI 246 Query: 213 MAELL----------TGR-TLFPGT-------DH----------IDQLKLILRLVGTPGA 244 AELL T R LFPG+ DH DQL +I ++GTP Sbjct: 247 FAELLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPE 306 Query: 245 ELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304 E LK I+ + YI+ ++ + + + +DLLE ML ++ KRIT +AL+ Sbjct: 307 EDLKCITKQEVIKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALS 366 Query: 305 HAYF 308 H Y Sbjct: 367 HPYL 370 >3N9X-A nrPDB Length = 432 Score = 204 bits (518), Expect = 6e-53, Method: Compositional matrix adjust. Identities = 123/361 (34%), Positives = 185/361 (51%), Gaps = 57/361 (15%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S R Y Q + VP+ Y +G G+YG V A+D T VA+KK++R F+ Sbjct: 8 SSGRENLYFQGIKNV--HVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFED 65 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 +I KR RE+ +L +K + +I L D+ P L +F+++Y+V + +DL + K Sbjct: 66 LIDCKRILREITILNRLKSDYIIRLYDLIIPD-DLLKFDELYIVLEIADSDLKKLFKTPI 124 Query: 122 -LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-- 178 LT++H++ ++Y +L G +IH + IIHRDLKP+N +N+DC +K+ DFGLAR + E Sbjct: 125 FLTEEHIKTILYNLLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKD 184 Query: 179 -----------------------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAE 215 +T +V TRWYRAPE++L +Y +++DIWS GCI AE Sbjct: 185 TNIVNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAE 244 Query: 216 LL----------TGR-TLFPGT-----------------DHIDQLKLILRLVGTPGAELL 247 LL T R LFPG+ + DQL +I ++GTP + L Sbjct: 245 LLNMLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDL 304 Query: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 K I+ YI+ +N + + ++LLE ML + +KRIT QAL H Y Sbjct: 305 KNINKPEVIKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPY 364 Query: 308 F 308 Sbjct: 365 L 365 >2BPM-A nrPDB Length = 309 Score = 191 bits (486), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 112/299 (37%), Positives = 162/299 (54%), Gaps = 14/299 (4%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E +Q + +G G YG V A + TG VA+KK+ ++ RE+ LLK + H Sbjct: 7 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 66 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL---IYQILRGL 138 N++ LLDV + N +YLV + DL + LT + + ++Q+L+GL Sbjct: 67 NIVKLLDV------IHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 120 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEIML 195 + HS ++HRDLKP NL +N + +K+ DFGLAR + Y V T WYRAPEI+L Sbjct: 121 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 180 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 +Y+ VDIWS+GCI AE++T R LFPG IDQL I R +GTP + ++S Sbjct: 181 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP- 239 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 314 +Y S + + +F+ V + LL +ML D +KRI+A ALAH +F P Sbjct: 240 -DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 297 >3NIZ-A nrPDB Length = 311 Score = 190 bits (482), Expect = 9e-49, Method: Compositional matrix adjust. Identities = 110/292 (37%), Positives = 158/292 (54%), Gaps = 13/292 (4%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E+YQ L VG G YG V A D++ G VA+K++ + RE+ LLK + H Sbjct: 21 EKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAIREISLLKELHHP 79 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK--LTDDHVQFLIYQILRGLK 139 N++ L+DV R L LV M DL ++ K L D ++ +YQ+LRG+ Sbjct: 80 NIVSLIDVIHSERCLT------LVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGVA 133 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEIMLN 196 + H I+HRDLKP NL +N D LK+ DFGLAR + Y V T WYRAP++++ Sbjct: 134 HCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMG 193 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 256 Y+ +VDIWS+GCI AE++TG+ LFPG DQL I ++GTP ++ E Sbjct: 194 SKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQV-QELPL 252 Query: 257 NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 ++ K ++++ G +DLL ML D +KRI+A A+ H YF Sbjct: 253 WKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYF 304 >1V0B-A nrPDB Length = 288 Score = 185 bits (470), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 110/294 (37%), Positives = 157/294 (53%), Gaps = 14/294 (4%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E+Y L +G G YG V A G A+KK+ + T RE+ +LK +KH Sbjct: 2 EKYHGLEKIGEGTYGVVYKA-QNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHS 60 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK-CQK-LTDDHVQFLIYQILRGLK 139 N++ L DV + L LV + DL ++ C+ L + + Q+L G+ Sbjct: 61 NIVKLYDVIHTKKRL------VLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIA 114 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEIMLN 196 Y H ++HRDLKP NL +N + ELKI DFGLAR + Y V T WYRAP++++ Sbjct: 115 YCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMG 174 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 256 Y+ T+DIWSVGCI AE++ G LFPG DQL I R++GTP ++ ++ Sbjct: 175 SKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVT--ELP 232 Query: 257 NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 Y + T + + + G + +DLL KML LD ++RITA QAL HAYF + Sbjct: 233 KYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >4KRC-A nrPDB Length = 317 Score = 180 bits (457), Expect = 8e-46, Method: Compositional matrix adjust. Identities = 105/301 (34%), Positives = 170/301 (56%), Gaps = 16/301 (5%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 +++ L +G+G Y +V + TG+ VA+K++ + + RE+ L+K +KHEN Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST-AIREISLMKELKHEN 64 Query: 83 VIGLLDVFTPARSLE---EFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLK 139 ++ L DV L EF D L ++ + N + +L + V++ +Q+L+GL Sbjct: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLEL--NLVKYFQWQLLQGLA 122 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD---DEMTGYVATRWYRAPEIMLN 196 + H I+HRDLKP NL +N+ +LK+ DFGLAR + + V T WYRAP++++ Sbjct: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 256 Y+ ++DIWS GCI+AE++TG+ LFPGT+ +QLKLI ++GTP L ++ Sbjct: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT--KLP 240 Query: 257 NYIQSLTQMPKMNFANVFI--GANPL---AVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311 Y ++ Q P + V PL +D L +L L+ D R++A QAL H +FA+Y Sbjct: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY 300 Query: 312 H 312 + Sbjct: 301 Y 301 >6GU6-A nrPDB Length = 302 Score = 176 bits (446), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 106/294 (36%), Positives = 157/294 (53%), Gaps = 15/294 (5%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E Y + +G G YG V TG VA+KK+ + RE+ LLK ++H Sbjct: 7 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 66 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADL----NNIVKCQKLTDDHVQFLIYQILRG 137 N++ L DV L + + +YL+ + DL ++I Q + V+ +YQIL+G Sbjct: 67 NIVSLQDV------LMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 120 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEIM 194 + + HS ++HRDLKP NL +++ +K+ DFGLAR + Y V T WYR+PE++ Sbjct: 121 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 180 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 L Y+ VDIWS+G I AEL T + LF G IDQL I R +GTP E+ ++ ES Sbjct: 181 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV--ES 238 Query: 255 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 ++Y + + + A+ + +DLL KML+ D KRI+ AL H YF Sbjct: 239 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 292 >1UA2-A nrPDB Length = 346 Score = 174 bits (441), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 107/301 (35%), Positives = 159/301 (52%), Gaps = 17/301 (5%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH---AKRTYRELRLLKHM 78 +RY+ L +G G + +V A D T VA+KK+ +S + RE++LL+ + Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL--TDDHVQFLIYQILR 136 H N+IGLLD F +++ LV M DL I+K L T H++ + L+ Sbjct: 70 SHPNIIGLLDAFG------HKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEI 193 GL+Y+H I+HRDLKP+NL ++E+ LK+ DFGLA+ Y V TRWYRAPE+ Sbjct: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 + Y VD+W+VGCI+AELL PG +DQL I +GTP E + S Sbjct: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHD 313 +Y+ + P + ++F A +DL++ + + + RITA QAL YF+ Sbjct: 244 P--DYV-TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 Query: 314 P 314 P Sbjct: 301 P 301 >4AU8-A nrPDB Length = 296 Score = 172 bits (435), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 107/299 (35%), Positives = 157/299 (52%), Gaps = 14/299 (4%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 ++Y+ L +G G YG+V A + +T VA+K++ RE+ LLK +KH+ Sbjct: 6 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 65 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQK-LTDDHVQFLIYQILRGLK 139 N++ L DV + L LV DL C L + V+ ++Q+L+GL Sbjct: 66 NIVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 119 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEIMLN 196 + HS +++HRDLKP NL +N + ELK+ DFGLAR + Y V T WYR P+++ Sbjct: 120 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 179 Query: 197 WMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 Y+ ++D+WS GCI AEL GR LFPG D DQLK I RL+GTP E ++ Sbjct: 180 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT--KL 237 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 314 +Y + NV N DLL+ +L + +RI+A +AL H YF+ + P Sbjct: 238 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 296 >1G3N-A nrPDB Length = 326 Score = 167 bits (423), Expect = 6e-42, Method: Compositional matrix adjust. Identities = 109/296 (36%), Positives = 161/296 (54%), Gaps = 15/296 (5%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLR-VAVKKLSRPFQSIIHAKRTYRELRLLKHMK- 79 ++Y+ ++ +G GAYG V A D K G R VA+K++ T RE+ +L+H++ Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 80 --HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLN---NIVKCQKLTDDHVQFLIYQI 134 H NV+ L DV T +R+ E + LV + DL + V + + ++ +++Q+ Sbjct: 71 FEHPNVVRLFDVCTVSRTDRE-TKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 135 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM--TGYVATRWYRAPE 192 LRGL ++HS ++HRDLKP N+ V ++K+ DFGLAR +M T V T WYRAPE Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 ++L Y VD+WSVGCI AE+ + LF G+ +DQL IL ++G PG E + Sbjct: 190 VLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR-DV 247 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 R S + P F + L DLL K L + KRI+A AL+H YF Sbjct: 248 ALPRQAFHSKSAQPIEKFVT---DIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 >5G6V-A nrPDB Length = 324 Score = 165 bits (417), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 109/302 (36%), Positives = 151/302 (50%), Gaps = 33/302 (10%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKL------SRPFQSIIHAKRTYRELRLL 75 E Y L +G G Y +V T VA+K++ P +I RE+ LL Sbjct: 2 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAI-------REVSLL 54 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK-CQKLTDDH-VQFLIYQ 133 K +KH N++ L D+ +SL LV + DL + C + + H V+ ++Q Sbjct: 55 KDLKHANIVTLHDIIHTEKSLT------LVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQ 108 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRA 190 +LRGL Y H ++HRDLKP NL +NE ELK+ DFGLAR Y V T WYR Sbjct: 109 LLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRP 168 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250 P+I+L Y+ +D+W VGCI E+ TGR LFPG+ +QL I R++GTP E I Sbjct: 169 PDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGI 228 Query: 251 -SSESARNYIQSLTQMPKMNFANVFIGANPL---AVDLLEKMLVLDSDKRITAAQALAHA 306 S+E + Y PK + A L DLL K+L + RI+A A+ H Sbjct: 229 LSNEEFKTY-----NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHP 283 Query: 307 YF 308 +F Sbjct: 284 FF 285 >4BBM-A nrPDB Length = 331 Score = 164 bits (416), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 103/301 (34%), Positives = 162/301 (53%), Gaps = 29/301 (9%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E+Y+NL VG G+YG V + TG VA+KK + K RE++LLK ++HE Sbjct: 25 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHE 84 Query: 82 NVIGLLDVFTPARS---LEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGL 138 N++ LL+V + + EF V H + DL + L VQ ++QI+ G+ Sbjct: 85 NLVNLLEVCKKKKRWYLVFEF-----VDHTILDDLE--LFPNGLDYQVVQKYLFQIINGI 137 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-------DDEMTGYVATRWYRAP 191 + HS +IIHRD+KP N+ V++ +K+ DFG AR DDE VATRWYRAP Sbjct: 138 GFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDE----VATRWYRAP 193 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 E+++ + Y + VD+W++GC++ E+ G LFPG IDQL I+ +G L+ + Sbjct: 194 ELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGN----LIPRHQ 249 Query: 252 SESARNYIQSLTQMPKMN----FANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 +N + + ++P++ + + + +DL +K L +D DKR A+ L H + Sbjct: 250 ELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDF 309 Query: 308 F 308 F Sbjct: 310 F 310 >4AGU-A nrPDB Length = 311 Score = 163 bits (412), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 103/324 (31%), Positives = 172/324 (53%), Gaps = 35/324 (10%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E+Y+ + +G G+YG V + TG VA+KK + K RE+R+LK +KH Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDH-VQFLIYQILRGLKY 140 N++ LL+VF R L + + L+ + + Q+ +H V+ + +Q L+ + + Sbjct: 63 NLVNLLEVFRRKRRLH-----LVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNF 117 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-------HTDDEMTGYVATRWYRAPEI 193 H + IHRD+KP N+ + + +K+ DFG AR + DDE VATRWYR+PE+ Sbjct: 118 CHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDE----VATRWYRSPEL 173 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 ++ Y VD+W++GC+ AELL+G L+PG +DQL LI + +G +L+ + Sbjct: 174 LVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLG----DLIPRHQQV 229 Query: 254 SARNYIQSLTQMP--------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAH 305 + N S ++P ++ F N+ + P A+ LL+ L +D +R+T Q L H Sbjct: 230 FSTNQYFSGVKIPDPEDMEPLELKFPNI---SYP-ALGLLKGCLHMDPTERLTCEQLLHH 285 Query: 306 AYFAQYHDPDDEPVADPYDQSFES 329 YF + +D +A +D+ E+ Sbjct: 286 PYFENIREIED--LAKEHDKPAEN 307 >3ZDU-A nrPDB Length = 325 Score = 161 bits (407), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 106/300 (35%), Positives = 159/300 (53%), Gaps = 24/300 (8%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKL-SRPFQSIIHAKRTYRELRLLKHMKH 80 E Y+ L VG G+YG+V TG VA+K RP QS+ K RE++ LK H Sbjct: 3 EMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSV--NKIAMREIKFLKQFHH 60 Query: 81 ENVIGLLDVFTPARSLEEFNDVY-LVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLK 139 EN++ L++VF R ++ + V+ + H + +L + C L ++ ++QILR + Sbjct: 61 ENLVNLIEVF---RQKKKIHLVFEFIDHTVLDELQHY--CHGLESKRLRKYLFQILRAID 115 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-------DDEMTGYVATRWYRAPE 192 Y+HS +IIHRD+KP N+ V++ K+ DFG AR DDE VATRWYRAPE Sbjct: 116 YLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDE----VATRWYRAPE 171 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 ++L Y + VDIW++GC++ E+ TG P + +D L I+ VG L+ I S Sbjct: 172 LVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPH-LQNIFS 230 Query: 253 ESA--RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 +S + Q PK N + N L D++ L +D RI+++ L H YF + Sbjct: 231 KSPIFAGVVLPQVQHPK-NARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTR 289 >5EFQ-A nrPDB Length = 347 Score = 159 bits (401), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 99/311 (31%), Positives = 157/311 (50%), Gaps = 14/311 (4%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 +++ + +G G YG V A D TG VA+KK+ + RE+++L+ + H+ Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 82 NVIGLLDVFTPARSLEEFND----VYLVTHLMGADLNNIVKCQ--KLTDDHVQFLIYQIL 135 ++I + ++ T +F YLV M DL +++ ++H++ + Q++ Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 130 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE----MTGYVATRWYRAP 191 GL Y H + +HRD+K SN+ +N ++K+ DFGLAR E T V T WYR P Sbjct: 131 EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 190 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 E++L Y +D+WS GCI+ EL T + +F + QL+LI R+ G+P + + Sbjct: 191 ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVI 250 Query: 252 SESARNYIQSLTQM-PKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 N ++ Q K+ VFI A A+DL + ML LD KR TA QAL F + Sbjct: 251 KLPYFNTMKPKKQYRRKLREEFVFIPAA--ALDLFDYMLALDPSKRCTAEQAL-QCEFLR 307 Query: 311 YHDPDDEPVAD 321 +P P D Sbjct: 308 DVEPSKMPPPD 318 >4NST-A nrPDB Length = 351 Score = 157 bits (398), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 93/297 (31%), Positives = 151/297 (50%), Gaps = 11/297 (3%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 +++ + +G G YG V A D TG VA+KK+ + RE+++L+ + H Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR 72 Query: 82 NVIGLLDVFTPARSLEEFND----VYLVTHLMGADLNNIVKCQ--KLTDDHVQFLIYQIL 135 +V+ + ++ T + +F YLV M DL +++ ++DH++ + Q++ Sbjct: 73 SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLM 132 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE----MTGYVATRWYRAP 191 GL+Y H + +HRD+K SN+ +N ++K+ DFGLAR + E T V T WYR P Sbjct: 133 EGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPP 192 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 E++L Y +D+WS GCI+ EL T + +F + QL+LI RL G+P + + Sbjct: 193 ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVI 252 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 N ++ Q + F A+DLL+ ML LD KR TA Q L + Sbjct: 253 KLPYFNTMKPKKQY-RRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL 308 >3EB0-A nrPDB Length = 383 Score = 157 bits (398), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 98/320 (30%), Positives = 164/320 (51%), Gaps = 50/320 (15%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G+G++G VC FD ++G R A+KK+ + + REL ++K + H N+I L+D Sbjct: 15 LGTGSFGIVCEVFDIESGKRFALKKV------LQDPRYKNRELDIMKVLDHVNIIKLVDY 68 Query: 90 F--------TPARSLEEFNDV----------------------YL--VTHLMGADLNNIV 117 F P + ++ N + YL + + L+ ++ Sbjct: 69 FYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDTLHKVL 128 Query: 118 KC-----QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGL 171 K + + + + IYQ+ R + +IHS I HRD+KP NL VN +D LK+ DFG Sbjct: 129 KSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDFGS 188 Query: 172 ARH--TDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI 229 A+ + Y+ +R+YRAPE+ML Y ++D+WS+GC+ EL+ G+ LF G I Sbjct: 189 AKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFSGETSI 248 Query: 230 DQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANP-LAVDLLEKM 288 DQL I++++GTP E + +++ +L ++ + P LA+DLLE++ Sbjct: 249 DQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKA---KDWRKILPEGTPSLAIDLLEQI 305 Query: 289 LVLDSDKRITAAQALAHAYF 308 L + D RI +A+AH +F Sbjct: 306 LRYEPDLRINPYEAMAHPFF 325 >5AIR-A nrPDB Length = 430 Score = 157 bits (397), Expect = 7e-39, Method: Compositional matrix adjust. Identities = 102/318 (32%), Positives = 171/318 (53%), Gaps = 31/318 (9%) Query: 16 TIWEVPERYQNLS-----PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR-TY 69 T + P+R Q +S +G+G++G V A +G VA+KK ++ KR Sbjct: 53 TPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK-------VLQDKRFKN 105 Query: 70 RELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYL--VTHLMGADLNNIVK-----CQKL 122 REL++++ + H N++ L F S E+ ++VYL V + + + + Q L Sbjct: 106 RELQIMRKLDHCNIVRLRYFFY--SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTL 163 Query: 123 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE-LKILDFGLARH--TDDEM 179 +V+ +YQ+ R L YIHS I HRD+KP NL ++ D LK+ DFG A+ + Sbjct: 164 PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN 223 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239 Y+ +R+YRAPE++ Y ++D+WS GC++AELL G+ +FPG +DQL I++++ Sbjct: 224 VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL 283 Query: 240 GTPGAELLKKISSESARNYIQ-SLTQMPKMNFANVFIGANPL-AVDLLEKMLVLDSDKRI 297 GTP E +++++ NY + Q+ + VF P A+ L ++L R+ Sbjct: 284 GTPTREQIREMNP----NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL 339 Query: 298 TAAQALAHAYFAQYHDPD 315 T +A AH++F + DP+ Sbjct: 340 TPLEACAHSFFDELRDPN 357 >4E7W-A nrPDB Length = 394 Score = 155 bits (392), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 101/296 (34%), Positives = 162/296 (54%), Gaps = 23/296 (7%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR-TYRELRLLKHMKHEN 82 Y N +G+G++G V A ++ VA+KK ++ KR REL++++ +KH N Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESD-EVAIKK-------VLQDKRFKNRELQIMRIVKHPN 93 Query: 83 VIGLLDVF--TPARSLEEFNDV---YLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 137 V+ L F + E F ++ Y+ + A + Q + ++ +YQ+LR Sbjct: 94 VVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRS 153 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCE-LKILDFGLARH--TDDEMTGYVATRWYRAPEIM 194 L YIHS I HRD+KP NL ++ LK++DFG A+ + Y+ +R+YRAPE++ Sbjct: 154 LAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELI 213 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 +Y +DIWS GC+MAEL+ G+ LFPG IDQL I++++GTP E +K ++ Sbjct: 214 FGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNP-- 271 Query: 255 ARNYIQ-SLTQMPKMNFANVFIGANPL-AVDLLEKMLVLDSDKRITAAQALAHAYF 308 NY++ Q+ F+ VF P A+DL+ ++L R+TA +AL H +F Sbjct: 272 --NYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFF 325 >4BGQ-A nrPDB Length = 304 Score = 154 bits (389), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 103/308 (33%), Positives = 163/308 (52%), Gaps = 30/308 (9%) Query: 16 TIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLL 75 I V +++ L VG GAYG V +T VA+KK ++ + T REL++L Sbjct: 6 NIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKML 65 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIYQ 133 + +K EN++ L + F L YLV + ++ +++ + + V+ IYQ Sbjct: 66 RTLKQENIVELKEAFRRRGKL------YLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQ 119 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH-TDDEMTGY---VATRWYR 189 +++ + + H DI+HRD+KP NL ++ + LK+ DFG AR+ ++ Y VATRWYR Sbjct: 120 LIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYR 179 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 +PE++L Y ++VD+WSVGCI+ EL G+ LFPG IDQL I +++G +E +K Sbjct: 180 SPELLLG-APYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKL 238 Query: 250 ISSE--------SARNYIQSLTQMPKMNFANVFIGA-NPLAVDLLEKMLVLDSDKRITAA 300 S A N+ QSL + ++G N + +DL++ +L LD R Sbjct: 239 FYSNPRFHGLRFPAVNHPQSLERR--------YLGILNSVLLDLMKNLLKLDPADRYLTE 290 Query: 301 QALAHAYF 308 Q L H F Sbjct: 291 QCLNHPTF 298 >3MIA-A nrPDB Length = 351 Score = 151 bits (382), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 100/309 (32%), Positives = 160/309 (51%), Gaps = 24/309 (7%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 +Y+ L+ +G G +G V A KTG +VA+KK+ + RE+++L+ +KHEN Sbjct: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 Query: 83 VIGLLDVFTPARSLEEFN----DVYLV----THLMGADLNNIVKCQKLTDDHVQFLIYQI 134 V+ L+++ S +N +YLV H + L+N++ K T ++ ++ + Sbjct: 78 VVNLIEICRTKAS--PYNRCKGSIYLVFDFCEHDLAGLLSNVL--VKFTLSEIKRVMQML 133 Query: 135 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-------HTDDEMTGYVATRW 187 L GL YIH I+HRD+K +N+ + D LK+ DFGLAR + T V T W Sbjct: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247 YR PE++L Y +D+W GCIMAE+ T + G QL LI +L G+ E+ Sbjct: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Query: 248 KKISSESARNYIQSLTQMPKMNFANVFIG--ANPLAVDLLEKMLVLDSDKRITAAQALAH 305 + + ++ L + K + +P A+DL++K+LVLD +RI + AL H Sbjct: 254 PNVDNYELYEKLE-LVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 Query: 306 AYFAQYHDP 314 +F + DP Sbjct: 313 DFF--WSDP 319 >2W96-B nrPDB Length = 306 Score = 149 bits (377), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 105/301 (34%), Positives = 153/301 (50%), Gaps = 28/301 (9%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK--- 79 RY+ ++ +G GAYG+V A D +G VA+K + P T RE+ LL+ ++ Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFE 64 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV---KCQKLTDDHVQFLIYQILR 136 H NV+ L+DV +R+ E V LV + DL + L + ++ L+ Q LR Sbjct: 65 HPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLR 123 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT--GYVATRWYRAPEIM 194 GL ++H+ I+HRDLKP N+ V +K+ DFGLAR +M V T WYRAPE++ Sbjct: 124 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEVL 183 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE-------LL 247 L Y VD+WSVGCI AE+ + LF G DQL I L+G P + L Sbjct: 184 LQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP 242 Query: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 + +QS+ +P+M + LL +ML + KRI+A +AL H+Y Sbjct: 243 RGAFPPRGPRPVQSV--VPEMEES---------GAQLLLEMLTFNPHKRISAFRALQHSY 291 Query: 308 F 308 Sbjct: 292 L 292 >3GC0-A nrPDB Length = 329 Score = 148 bits (373), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 102/300 (34%), Positives = 153/300 (51%), Gaps = 20/300 (6%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 +RY+ ++ +G G YG V A DT T VA+K++ + RE+ LLK ++H Sbjct: 34 DRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHR 93 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQKLTDDHVQFLIYQILRGLKY 140 N+I L V + + ++L+ DL + K ++ ++ +YQ++ G+ + Sbjct: 94 NIIELKSV------IHHNHRLHLIFEYAENDLKKYMDKNPDVSMRVIKSFLYQLINGVNF 147 Query: 141 IHSADIIHRDLKPSNL--AVNEDCE---LKILDFGLARHTD---DEMTGYVATRWYRAPE 192 HS +HRDLKP NL +V++ E LKI DFGLAR + T + T WYR PE Sbjct: 148 CHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPE 207 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 I+L HY+ +VDIWS+ CI AE+L LFPG IDQL I ++G P ++ Sbjct: 208 ILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVT- 266 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLE--KMLVLDSDKRITAAQALAHAYFAQ 310 + ++ QS + V +GA L ML +D KRI+A AL H YF+ Sbjct: 267 -ALPDWKQSFPKFRGKTLKRV-LGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFSH 324 >5Y86-A nrPDB Length = 588 Score = 144 bits (362), Expect = 7e-35, Method: Compositional matrix adjust. Identities = 101/325 (31%), Positives = 159/325 (48%), Gaps = 45/325 (13%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR----ELRLLKHM 78 RY+ L +G G++G V +D K VA+K + + KR +R E+R+L+H+ Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALK-------MVRNEKRFHRQAAEEIRILEHL 260 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL---IYQIL 135 K ++ G ++V S N V + L+ DL ++K K VQ + IL Sbjct: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSIL 320 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNED--CELKILDFGLARHTDDEMTGYVATRWYRAPEI 193 + L +H IIH DLKP N+ + K++DFG + ++ Y+ +R+YRAPEI Sbjct: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEI 380 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK---- 249 +L Y+ +DIWS GCI+AELLTG+ LFPG D DQL ++ L+G P +LL++ Sbjct: 381 ILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 Query: 250 ---ISSESARNYIQSLTQM--------------------PKMNFANVFIGANP-LAVDLL 285 I+S+ Y TQ ++ G + L ++ L Sbjct: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499 Query: 286 EKMLVLDSDKRITAAQALAHAYFAQ 310 ++ L D R+T AQAL H + ++ Sbjct: 500 KRCLHWDPSARLTPAQALRHPWISK 524 >3E3P-A nrPDB Length = 360 Score = 143 bits (361), Expect = 9e-35, Method: Compositional matrix adjust. Identities = 94/310 (30%), Positives = 160/310 (51%), Gaps = 25/310 (8%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-- 79 +R+Q G G +G+V + TG+ VA+KK+ I + REL++++ + Sbjct: 23 DRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKV------IQDPRFRNRELQIMQDLAVL 76 Query: 80 -HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDH--------VQFL 130 H N++ L F + D+YL +M + + +C + ++ Sbjct: 77 HHPNIVQLQSYFYTLGERDR-RDIYLNV-VMEYVPDTLHRCCRNYYRRQVAPPPILIKVF 134 Query: 131 IYQILRGLKYIH--SADIIHRDLKPSNLAVNE-DCELKILDFGLARH--TDDEMTGYVAT 185 ++Q++R + +H S ++ HRD+KP N+ VNE D LK+ DFG A+ + Y+ + Sbjct: 135 LFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICS 194 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 R+YRAPE++ HY VDIWSVGCI AE++ G +F G + QL I+R++G P E Sbjct: 195 RYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSRE 254 Query: 246 LLKKISSESARNYIQSLTQMPKMN-FANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304 +L+K++ + + +P N F++ + A DLL +L ++R+ +AL Sbjct: 255 VLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEALC 314 Query: 305 HAYFAQYHDP 314 H YF + HDP Sbjct: 315 HPYFDELHDP 324 >5ZTN-A nrPDB Length = 429 Score = 139 bits (351), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 102/334 (30%), Positives = 164/334 (49%), Gaps = 61/334 (18%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR----ELRLL 75 V RY+ L +G G++G V A+D K VA+K + + KR +R E+R+L Sbjct: 95 VAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALK-------MVRNEKRFHRQAAEEIRIL 147 Query: 76 KHMKHE------NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDH--- 126 +H++ + NVI +L+ FT N + + L+ +L ++K K Sbjct: 148 EHLRKQDKDNTMNVIHMLENFTFR------NHICMTFELLSMNLYELIKKNKFQGFSLPL 201 Query: 127 VQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE--LKILDFGLARHTDDEMTGYVA 184 V+ + IL+ L +H IIH DLKP N+ + + +K++DFG + + + Y+ Sbjct: 202 VRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQ 261 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGA 244 +R+YRAPE++L Y +D+WS+GCI+AELLTG L PG D DQL ++ L+G P Sbjct: 262 SRFYRAPEVILG-ARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQ 320 Query: 245 ELLKKISSESARNYIQS----------------------------LTQMPK-MNFANVFI 275 +LL +S+ A+N++ S L P+ + N Sbjct: 321 KLLD--ASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALK 378 Query: 276 GA-NPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 G +PL +D L++ L D R+T QAL H + Sbjct: 379 GCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 412 >5XVU-A nrPDB Length = 332 Score = 137 bits (344), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 92/309 (29%), Positives = 159/309 (51%), Gaps = 31/309 (10%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 W P RY+ + +G G Y V +DT+ A+K L + I + L Sbjct: 27 WNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKVLKPVKKKKIKREIK----ILQNL 82 Query: 78 MKHENVIGLLDVF------TPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLI 131 N+I LLD+ TP+ E N++ D + K TD +++ I Sbjct: 83 NGGPNIIKLLDIVKDPVTKTPSLIFEYINNI---------DFKTLY--PKFTDKDIRYYI 131 Query: 132 YQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR--HTDDEMTGYVATRWY 188 YQIL+ L Y HS I+HRD+KP N+ ++ E+ +++++ +GLA H E VA+R+Y Sbjct: 132 YQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRYY 191 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRT-LFPGTDHIDQLKLILRLVGTPGAE-L 246 + PE++++ Y+ ++DIWS+GC++A ++ + F G D+ DQL I +++GT Sbjct: 192 KGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAY 251 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGAN-----PLAVDLLEKMLVLDSDKRITAAQ 301 LKK + + +Y+ L + + +++ +N +DL++KML+ D KRI + Sbjct: 252 LKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKE 311 Query: 302 ALAHAYFAQ 310 A+ H YF + Sbjct: 312 AMEHPYFRE 320 >6O6Q-A nrPDB Length = 335 Score = 135 bits (339), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 89/314 (28%), Positives = 163/314 (51%), Gaps = 46/314 (14%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 W E Y+ L +G G Y V D + +V +K L +P + K+ RE+ +LK+ Sbjct: 37 WNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVL-KP----VKRKKIKREISILKN 91 Query: 78 M-KHENVIGLLDVF------TPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL 130 + N+I +LDV TP E N++ D ++ TD ++F Sbjct: 92 LVDGPNIIAMLDVVREPQSKTPGLIFEHINNI---------DFRSLYPT--FTDYDIRFY 140 Query: 131 IYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE-LKILDFGLAR--HTDDEMTGYVATRW 187 +Y++L+ L Y HS I+HRD+KP N+ ++ D + L+++D+GLA H E VA+R+ Sbjct: 141 MYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRY 200 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRT-LFPGTDHIDQLKLILRLVGTPG--- 243 ++ PE+++++ Y+ ++D+WS GC++A ++ + F G + DQL I+R++G+ Sbjct: 201 FKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKK 260 Query: 244 ---------AELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSD 294 E + I + R +++ + + K + F+ DL++++L D Sbjct: 261 YLEKYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFL-------DLIDRLLRYDHQ 313 Query: 295 KRITAAQALAHAYF 308 +R+TA +A+ HAYF Sbjct: 314 ERLTAKEAMKHAYF 327 >4CRL-A nrPDB Length = 406 Score = 130 bits (327), Expect = 9e-31, Method: Compositional matrix adjust. Identities = 112/350 (32%), Positives = 163/350 (46%), Gaps = 57/350 (16%) Query: 30 VGSGAYGSV--CAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLL 87 VG G YG V D K A+K++ S+ RE+ LL+ +KH NVI L Sbjct: 30 VGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISM----SACREIALLRELKHPNVISLQ 85 Query: 88 DVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK----------LTDDHVQFLIYQILRG 137 VF V+L+ DL +I+K + L V+ L+YQIL G Sbjct: 86 KVFLSHAD----RKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDG 141 Query: 138 LKYIHSADIIHRDLKPSNLAV----NEDCELKILDFGLARHTDD------EMTGYVATRW 187 + Y+H+ ++HRDLKP+N+ V E +KI D G AR + ++ V T W Sbjct: 142 IHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFW 201 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLF---------PGTDHIDQLKLILRL 238 YRAPE++L HY + +DIW++GCI AELLT +F H DQL I + Sbjct: 202 YRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNV 261 Query: 239 VGTPGA---ELLKKISSESA------RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKML 289 +G P E +KK+ S RN + + + M V + A LL+K+L Sbjct: 262 MGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKV--KPDSKAFHLLQKLL 319 Query: 290 VLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQS---FESRDLLIDE 336 +D KRIT+ QA+ YF + D P +D + + R+ L +E Sbjct: 320 TMDPIKRITSEQAMQDPYFLE----DPLPTSDVFAGCQIPYPKREFLTEE 365 >6HMD-A nrPDB Length = 365 Score = 127 bits (318), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 101/323 (31%), Positives = 163/323 (50%), Gaps = 37/323 (11%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRE-LRLLK 76 W + YQ + +G G Y V A + RV VK L + I + E LR Sbjct: 49 WGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLR--- 105 Query: 77 HMKHENVIGLLDVF------TPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL 130 N+I L+D TPA E N+ D + Q LTD ++F Sbjct: 106 --GGTNIIKLIDTVKDPVSKTPALVFEYINNT---------DFKQLY--QILTDFDIRFY 152 Query: 131 IYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR--HTDDEMTGYVATRW 187 +Y++L+ L Y HS I+HRD+KP N+ ++ + +L+++D+GLA H E VA+R+ Sbjct: 153 MYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY 212 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRT-LFPGTDHIDQLKLILRLVGTPGAEL 246 ++ PE+++++ Y+ ++D+WS+GC++A ++ R F G D+ DQL I +++GT EL Sbjct: 213 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT--EEL 270 Query: 247 ---LKKISSESARNYIQSLTQMPKMNFANVFIGAN-----PLAVDLLEKMLVLDSDKRIT 298 LKK + ++ L Q + + N N P A+DLL+K+L D +R+T Sbjct: 271 YGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT 330 Query: 299 AAQALAHAYFAQYHDPDDEPVAD 321 A +A+ H YF +P AD Sbjct: 331 AKEAMEHPYFYPVVKEQSQPSAD 353 >5X8I-B nrPDB Length = 346 Score = 126 bits (316), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 89/322 (27%), Positives = 147/322 (45%), Gaps = 40/322 (12%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 RY+ + +G GA+G V D K G R K+ + A R+ E+++L+H+ + Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARS--EIQVLEHLNTTD 71 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTD---DHVQFLIYQILRGLK 139 E + +V L+G + +K DH++ + YQI + + Sbjct: 72 PNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVN 131 Query: 140 YIHSADIIHRDLKPSN-LAVNEDC------------------ELKILDFGLARHTDDEMT 180 ++HS + H DLKP N L V D ++K++DFG A + D+ + Sbjct: 132 FLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHS 191 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240 V+TR YRAPE++L + ++Q D+WS+GCI+ E G T+FP D + L ++ R++G Sbjct: 192 TLVSTRHYRAPEVILA-LGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILG 250 Query: 241 TPGAELLKKISSE--------------SARNYIQSLTQMPKMNFANVFIGANPLAVDLLE 286 +++K SA Y+ + P F + DL++ Sbjct: 251 PLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACK-PLKEFMLSQDVEHERLFDLIQ 309 Query: 287 KMLVLDSDKRITAAQALAHAYF 308 KML D KRIT +AL H +F Sbjct: 310 KMLEYDPAKRITLREALKHPFF 331 >4RGJ-A nrPDB Length = 520 Score = 126 bits (316), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 101/335 (30%), Positives = 162/335 (48%), Gaps = 57/335 (17%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S+ RP + Q N E+Y+ + +G G++G V + D TG A+K +S+ Sbjct: 43 SKLRPGMFIQNSNVVF---NEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKK--- 96 Query: 62 IIHAKRT------YRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHL-MGADL- 113 H KR RE+ LLK + H N++ L + F E+ N YLV+ + G +L Sbjct: 97 --HVKRKTDKESLLREVELLKMLDHINIMKLYEFF------EDNNYYYLVSDVYTGGELF 148 Query: 114 NNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV----NEDCELKILDF 169 + I+ ++ + +I QIL G+ Y+H +++HRDLKP N+ + ED +KI+DF Sbjct: 149 DEIISRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDF 208 Query: 170 GLARHTD--DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTD 227 GL+ H + +M + T +Y AP+++ Y++ DIWS G I+ LL+G F G++ Sbjct: 209 GLSTHFEYSKKMKDKIGTAYYIAPDVLHGT--YDEKCDIWSCGVILYILLSGCPPFNGSN 266 Query: 228 HIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEK 287 D +LKK+ A Y L Q K+ + A DL++K Sbjct: 267 EYD---------------ILKKV---EAGKYTFDLPQFKKI---------SDKAKDLIKK 299 Query: 288 MLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADP 322 ML+ S RI+A AL H + D+ + P Sbjct: 300 MLMYTSAVRISARDALEHEWIKMMTSKDNLNIDIP 334 >3LIJ-A nrPDB Length = 494 Score = 124 bits (311), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 96/310 (30%), Positives = 150/310 (48%), Gaps = 42/310 (13%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 + E YQ + +GSGAYG V D T + A+K + + S + E+ +LK + Sbjct: 35 LSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLD 94 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHL-MGADL-NNIVKCQKLTDDHVQFLIYQILRG 137 H N++ L D F R + YLV G +L + I+ K + +I Q+L G Sbjct: 95 HPNIMKLYDFFEDKR------NYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSG 148 Query: 138 LKYIHSADIIHRDLKPSNL---AVNEDCELKILDFGLAR--HTDDEMTGYVATRWYRAPE 192 + Y+H +I+HRDLKP NL + +D +KI+DFGL+ +M + T +Y APE Sbjct: 149 VTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPE 208 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 ++ Y++ D+WS+G I+ LL G F G DQ E+L+K+ Sbjct: 209 VLRK--KYDEKCDVWSIGVILFILLAGYPPFGG--QTDQ-------------EILRKV-- 249 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYH 312 E + S P+ + NV GA DL+++ML DS +RI+A QAL H + + Sbjct: 250 EKGKYTFDS----PE--WKNVSEGAK----DLIKQMLQFDSQRRISAQQALEHPWIKEMC 299 Query: 313 DPDDEPVADP 322 + + P Sbjct: 300 SKKESGIELP 309 >3NCG-A nrPDB Length = 486 Score = 124 bits (310), Expect = 8e-29, Method: Compositional matrix adjust. Identities = 88/297 (29%), Positives = 144/297 (48%), Gaps = 42/297 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 ERY + +G G++G V D T AVK +++ RE+ LLK + H Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHL-MGADL-NNIVKCQKLTDDHVQFLIYQILRGLK 139 N++ L ++ LE+ + Y+V L G +L + I+K ++ ++ +I Q+ G+ Sbjct: 82 NIMKLFEI------LEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGIT 135 Query: 140 YIHSADIIHRDLKPSNL---AVNEDCELKILDFGLAR--HTDDEMTGYVATRWYRAPEIM 194 Y+H +I+HRDLKP N+ + +DC++KI+DFGL+ + +M + T +Y APE++ Sbjct: 136 YMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL 195 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 Y++ D+WS G I+ LL+G F G + D LK + E+ Sbjct: 196 RG--TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV-----------------ET 236 Query: 255 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311 + Y L Q + + A DL+ KML RITA Q L H + +Y Sbjct: 237 GK-YAFDLPQWRTI---------SDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKY 283 >3DFA-A nrPDB Length = 286 Score = 123 bits (309), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 88/297 (29%), Positives = 144/297 (48%), Gaps = 42/297 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 ERY + +G G++G V D T AVK +++ RE+ LLK + H Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHL-MGADL-NNIVKCQKLTDDHVQFLIYQILRGLK 139 N++ L ++ LE+ + Y+V L G +L + I+K ++ ++ +I Q+ G+ Sbjct: 82 NIMKLFEI------LEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGIT 135 Query: 140 YIHSADIIHRDLKPSNL---AVNEDCELKILDFGLAR--HTDDEMTGYVATRWYRAPEIM 194 Y+H +I+HRDLKP N+ + +DC++KI+DFGL+ + +M + T +Y APE++ Sbjct: 136 YMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL 195 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 Y++ D+WS G I+ LL+G F G + D LK + E+ Sbjct: 196 RG--TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV-----------------ET 236 Query: 255 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311 + Y L Q + + A DL+ KML RITA Q L H + +Y Sbjct: 237 GK-YAFDLPQWRTI---------SDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKY 283 >3MA6-A nrPDB Length = 298 Score = 120 bits (301), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 91/298 (30%), Positives = 144/298 (48%), Gaps = 43/298 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLS-RPFQSIIHAKRTYRELRLLKHMKH 80 +RY+ +G G++G V D TG AVK +S R + + RE++LLK + H Sbjct: 32 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 91 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHL-MGADL-NNIVKCQKLTDDHVQFLIYQILRGL 138 N++ L + F E+ YLV + G +L + I+ ++ ++ +I Q+L G+ Sbjct: 92 PNIMKLYEFF------EDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGI 145 Query: 139 KYIHSADIIHRDLKPSNL---AVNEDCELKILDFGLARH--TDDEMTGYVATRWYRAPEI 193 Y+H I+HRDLKP NL + ++D ++I+DFGL+ H +M + T +Y APE+ Sbjct: 146 TYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEV 205 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 + Y++ D+WS G I+ LL+G F G + D LK + + T KK+S E Sbjct: 206 LHG--TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVS-E 262 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311 SA+ DL+ KML RI+A AL H + Y Sbjct: 263 SAK--------------------------DLIRKMLTYVPSMRISARDALDHEWIQTY 294 >6EII-A nrPDB Length = 352 Score = 120 bits (301), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 76/243 (31%), Positives = 131/243 (53%), Gaps = 27/243 (11%) Query: 82 NVIGLLDVF------TPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQIL 135 N+I L D+ TPA E H+ D + Q LTD ++F +Y+IL Sbjct: 116 NIITLADIVKDPVSRTPALVFE---------HVNNTDFKQLY--QTLTDYDIRFYMYEIL 164 Query: 136 RGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR--HTDDEMTGYVATRWYRAPE 192 + L Y HS I+HRD+KP N+ ++ E +L+++D+GLA H E VA+R+++ PE Sbjct: 165 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 224 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRT-LFPGTDHIDQLKLILRLVGTPG-AELLKKI 250 +++++ Y+ ++D+WS+GC++A ++ + F G D+ DQL I +++GT + + K Sbjct: 225 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 284 Query: 251 SSESARNYIQSLTQMPKMNFANVFIGAN-----PLAVDLLEKMLVLDSDKRITAAQALAH 305 + E + L + + + N P A+D L+K+L D R+TA +A+ H Sbjct: 285 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 344 Query: 306 AYF 308 YF Sbjct: 345 PYF 347 >5JN2-A nrPDB Length = 525 Score = 120 bits (300), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 91/299 (30%), Positives = 144/299 (48%), Gaps = 43/299 (14%) Query: 21 PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLS-RPFQSIIHAKRTYRELRLLKHMK 79 +RY+ +G G++G V D TG AVK +S R + + RE++LLK + Sbjct: 66 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLD 125 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHL-MGADL-NNIVKCQKLTDDHVQFLIYQILRG 137 H N++ L + F E+ YLV + G +L + I+ ++ ++ +I Q+L G Sbjct: 126 HPNIMKLYEFF------EDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSG 179 Query: 138 LKYIHSADIIHRDLKPSNL---AVNEDCELKILDFGLARH--TDDEMTGYVATRWYRAPE 192 + Y+H I+HRDLKP NL + ++D ++I+DFGL+ H +M + T +Y APE Sbjct: 180 ITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPE 239 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 ++ Y++ D+WS G I+ LL+G F G + D LK + + T KK+S Sbjct: 240 VLHG--TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVS- 296 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311 ESA+ DL+ KML RI+A AL H + Y Sbjct: 297 ESAK--------------------------DLIRKMLTYVPSMRISARDALDHEWIQTY 329 >4LFI-A nrPDB Length = 374 Score = 119 bits (299), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 75/249 (30%), Positives = 136/249 (54%), Gaps = 27/249 (10%) Query: 77 HMKHENVIGLLDVF------TPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL 130 H H N+I L D+ TPA E ++V + + KLTD ++F Sbjct: 129 HNGHANIIHLFDIIKDPISKTPALVFEYVDNV-----------DFRILYPKLTDLEIRFY 177 Query: 131 IYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR--HTDDEMTGYVATRW 187 ++++L+ L Y HS I+HRD+KP N+ ++ ++ +L+++D+GLA H + E VA+R+ Sbjct: 178 MFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF 237 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRT-LFPGTDHIDQLKLILRLVGTPGAE- 245 ++ PE+++++ Y+ ++D+WS G ++A ++ R F GT + DQL I++++GT E Sbjct: 238 FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEK 297 Query: 246 LLKKISSESARNYIQSLTQMPK-----MNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300 L K R + + K +N N + N +DL++ +L D +R+TA Sbjct: 298 YLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAK 357 Query: 301 QALAHAYFA 309 +A+ H +FA Sbjct: 358 EAMGHPWFA 366 >4MD7-E nrPDB Length = 391 Score = 119 bits (298), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 76/243 (31%), Positives = 131/243 (53%), Gaps = 27/243 (11%) Query: 82 NVIGLLDVF------TPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQIL 135 N+I L D+ TPA E N+ D + Q LTD ++F +Y+IL Sbjct: 93 NIITLADIVKDPVSRTPALVFEHVNNT---------DFKQLY--QTLTDYDIRFYMYEIL 141 Query: 136 RGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR--HTDDEMTGYVATRWYRAPE 192 + L Y HS I+HRD+KP N+ ++ E +L+++D+GLA H E VA+R+++ PE Sbjct: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGR-TLFPGTDHIDQLKLILRLVGTPG-AELLKKI 250 +++++ Y+ ++D+WS+GC++A ++ + F G D+ DQL I +++GT + + K Sbjct: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 Query: 251 SSESARNYIQSLTQMPKMNFANVFIGAN-----PLAVDLLEKMLVLDSDKRITAAQALAH 305 + E + L + + + N P A+D L+K+L D R+TA +A+ H Sbjct: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321 Query: 306 AYF 308 YF Sbjct: 322 PYF 324 >3IS5-A nrPDB Length = 285 Score = 119 bits (297), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 88/292 (30%), Positives = 141/292 (48%), Gaps = 48/292 (16%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +GSGA+G V + +GL +K +++ +S + ++ E+ +LK + H N+I + +V Sbjct: 30 LGSGAFGDVHLVEERSSGLERVIKTINKD-RSQVPMEQIEAEIEVLKSLDHPNIIKIFEV 88 Query: 90 FTPARSLEEFNDVYLV--THLMGADLNNIVKCQK----LTDDHVQFLIYQILRGLKYIHS 143 F E+++++Y+V T G L IV Q L++ +V L+ Q++ L Y HS Sbjct: 89 F------EDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHS 142 Query: 144 ADIIHRDLKPSNLAVNEDCE---LKILDFGLAR--HTDDEMTGYVATRWYRAPEIMLNWM 198 ++H+DLKP N+ + +KI+DFGLA +D+ T T Y APE+ + Sbjct: 143 QHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVFKRDV 202 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY 258 + DIWS G +M LLTG F GT + Sbjct: 203 TFK--CDIWSAGVVMYFLLTGCLPFTGT----------------------------SLEE 232 Query: 259 IQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 +Q + N+A P AVDLL++ML D ++R +AAQ L H +F Q Sbjct: 233 VQQKATYKEPNYAVECRPLTPQAVDLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >2PVN-A nrPDB Length = 352 Score = 117 bits (293), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 67/199 (33%), Positives = 117/199 (58%), Gaps = 10/199 (5%) Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC-ELKILDFGLAR--HTDDE 178 LTD +++ IY++L+ L Y HS I+HRD+KP N+ ++ + +L+++D+GLA H E Sbjct: 143 LTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKE 202 Query: 179 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRT-LFPGTDHIDQLKLILR 237 VA+R+++ PE++++ Y+ ++D+WS+GC+ A ++ + F G D+ DQL I + Sbjct: 203 YNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAK 262 Query: 238 LVGTPGAE-LLKKISSE---SARNYIQSLTQMPKMNFANVFIG--ANPLAVDLLEKMLVL 291 ++GT G L K E + ++ P + F N +P A+D L+K+L Sbjct: 263 VLGTDGLNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRY 322 Query: 292 DSDKRITAAQALAHAYFAQ 310 D +R+TA +A+ H YF Q Sbjct: 323 DHQERLTALEAMTHPYFQQ 341 >2YCR-A nrPDB Length = 323 Score = 115 bits (288), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 99/334 (29%), Positives = 161/334 (48%), Gaps = 62/334 (18%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRT------YRELRLLKHMKHENV 83 +GSGA G V AF+ KT +VA+K +S+ +I A+ E+ +LK + H + Sbjct: 18 LGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCI 77 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 I + + F + D Y+V LM G + +V ++L + + YQ+L ++Y+ Sbjct: 78 IKIKNFF-------DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYL 130 Query: 142 HSADIIHRDLKPSNLAVN---EDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLN 196 H IIHRDLKP N+ ++ EDC +KI DFG ++ + M T Y APE++++ Sbjct: 131 HENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVS 190 Query: 197 --WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 YN+ VD WS+G I+ L+G P ++H Q+ L Sbjct: 191 VGTAGYNRAVDCWSLGVILFICLSGYP--PFSEHRTQVSL-------------------- 228 Query: 255 ARNYIQSLTQMPKMNF-ANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHD 313 ++ I S K NF V+ + A+DL++K+LV+D R T +AL H + Sbjct: 229 -KDQITS----GKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL----- 278 Query: 314 PDDEPVADPYDQSFESRDLLIDEWKSLTYDEVIS 347 DE D + +DLL +E +S +V++ Sbjct: 279 -QDE------DMKRKFQDLLSEENESTAKPQVLA 305 >6FYV-A nrPDB Length = 337 Score = 115 bits (288), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 92/326 (28%), Positives = 153/326 (46%), Gaps = 48/326 (14%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKT-GLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 RY+ + +G GA+G V D G+ VAVK + + A R+ E+++L+H+ Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVK-IVKNVGRYREAARS--EIQVLEHL--- 68 Query: 82 NVIGLLDVFTPARSLEEFND---VYLVTHLMGADLNNIVKCQKLTD---DHVQFLIYQIL 135 N VF + LE F+ V +V L+G + +K DH++ + YQI Sbjct: 69 NSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQIC 128 Query: 136 RGLKYIHSADIIHRDLKPSN-LAVNED------------------CELKILDFGLARHTD 176 + + ++H + H DLKP N L V D ++K++DFG A + D Sbjct: 129 QSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDD 188 Query: 177 DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 + + V+TR YRAPE++L + ++Q D+WS+GCI+ E G T+F D + L ++ Sbjct: 189 EHHSTLVSTRHYRAPEVILA-LGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMME 247 Query: 237 RLVGTPGAELLKKISSE--------------SARNYIQSLTQMPKMNFANVFIGANPLAV 282 R++G +++K SA Y++ + P F + Sbjct: 248 RILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCK-PLKEFMLCHDEEHEKLF 306 Query: 283 DLLEKMLVLDSDKRITAAQALAHAYF 308 DL+ +ML D +RIT +AL H +F Sbjct: 307 DLVRRMLEYDPTQRITLDEALQHPFF 332 >3DXN-A nrPDB Length = 287 Score = 114 bits (286), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 91/316 (28%), Positives = 147/316 (46%), Gaps = 46/316 (14%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP-FQ 60 S R Y Q L+ +RYQ + +GSGAYG V D TG A+K + + Sbjct: 8 SSGRENLYFQGLS-------DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVT 60 Query: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120 + ++ E+ +LK + H N++ L + F R+ +VY L + I+ Q Sbjct: 61 TTSNSGALLDEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGEL----FDEIILRQ 116 Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV---NEDCELKILDFGLARHTD- 176 K ++ ++ Q+L G Y+H +I+HRDLKP NL + + D +KI+DFGL+ H + Sbjct: 117 KFSEVDAAVIMKQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEV 176 Query: 177 -DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLI 235 +M + T +Y APE++ Y++ D+WS G I+ LL G F G DQ Sbjct: 177 GGKMKERLGTAYYIAPEVLRK--KYDEKCDVWSCGVILYILLCGYPPFGG--QTDQ---- 228 Query: 236 LRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDK 295 E+LK++ TQ+ + A L++ ML + K Sbjct: 229 ---------EILKRVEKGKFSFDPPDWTQV------------SDEAKQLVKLMLTYEPSK 267 Query: 296 RITAAQALAHAYFAQY 311 RI+A +AL H + ++ Sbjct: 268 RISAEEALNHPWIVKF 283 >3HZT-A nrPDB Length = 467 Score = 114 bits (284), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 86/298 (28%), Positives = 142/298 (47%), Gaps = 39/298 (13%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP-FQSIIHAKRTYRELRLLKHM 78 + +RYQ + +GSGAYG V D TG A+K + + + ++ E+ +LK + Sbjct: 2 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 61 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGL 138 H N++ L + F R+ +VY L + I+ QK ++ ++ Q+L G Sbjct: 62 DHPNIMKLYEFFEDKRNYYLVMEVYRGGEL----FDEIILRQKFSEVDAAVIMKQVLSGT 117 Query: 139 KYIHSADIIHRDLKPSNL---AVNEDCELKILDFGLARHTD--DEMTGYVATRWYRAPEI 193 Y+H +I+HRDLKP NL + + D +KI+DFGL+ H + +M + T +Y APE+ Sbjct: 118 TYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEV 177 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 + Y++ D+WS G I+ LL G F G DQ E+LK++ Sbjct: 178 LRK--KYDEKCDVWSCGVILYILLCGYPPFGG--QTDQ-------------EILKRVEKG 220 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311 TQ+ + A L++ ML + KRI+A +AL H + ++ Sbjct: 221 KFSFDPPDWTQV------------SDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKF 266 >3I6U-A nrPDB Length = 419 Score = 113 bits (282), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 89/295 (30%), Positives = 145/295 (49%), Gaps = 50/295 (16%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRT------YRELRLLKHMKHENV 83 +GSGA G V AF+ KT +VA++ +S+ +I A+ E+ +LK + H + Sbjct: 143 LGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILKKLNHPCI 202 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 I + + F + D Y+V LM G + +V ++L + + YQ+L ++Y+ Sbjct: 203 IKIKNFF-------DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYL 255 Query: 142 HSADIIHRDLKPSNLAVN---EDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLN 196 H IIHRDLKP N+ ++ EDC +KI DFG ++ + M T Y APE++++ Sbjct: 256 HENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVS 315 Query: 197 --WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 YN+ VD WS+G I+ L+G P ++H Q+ L Sbjct: 316 VGTAGYNRAVDCWSLGVILFICLSGYP--PFSEHRTQVSL-------------------- 353 Query: 255 ARNYIQSLTQMPKMNF-ANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 ++ I S K NF V+ + A+DL++K+LV+D R T +AL H + Sbjct: 354 -KDQITS----GKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 403 >4IAN-A nrPDB Length = 358 Score = 111 bits (277), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 99/351 (28%), Positives = 160/351 (45%), Gaps = 67/351 (19%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDT-KTGLRVAVKKLSR-------PF 59 +YR + + + +RY G G + +V A D + VAVK + Sbjct: 19 YYRVNIGEVL---DKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGL 75 Query: 60 QSIIHAKR--------TYRELRLLKHMKHENVIGLLDVFTP-ARSLEEFNDVYLVTHLMG 110 + + K+ + LRL +H H+ + L VF P + +L E Y G Sbjct: 76 KELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCL--VFEPLSMNLREVLKKY------G 127 Query: 111 ADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE-LKILDF 169 D+ +K V+ Q+ LK + +I+H D+KP N+ VNE LK+ DF Sbjct: 128 KDVGLHIKA-------VRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDF 180 Query: 170 GLARHT-DDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDH 228 G A H D+++T Y+ +R+YRAPEI++ Y+ +D+WSVGC + EL TG+ LFPG + Sbjct: 181 GSASHVADNDITPYLVSRFYRAPEIIIG-KSYDYGIDMWSVGCTLYELYTGKILFPGKTN 239 Query: 229 IDQLKLILRLVGTPGAELLKK------------------ISSESARNYIQSLTQM-PKMN 269 LKL + L G ++++K + + R + ++ + P + Sbjct: 240 NHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKD 299 Query: 270 FANVFIGANPLA----------VDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 IG L DLL+++L+LD KRI+ QAL HA+ + Sbjct: 300 LLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 350 >3Q5I-A nrPDB Length = 504 Score = 107 bits (267), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 88/311 (28%), Positives = 139/311 (44%), Gaps = 53/311 (17%) Query: 19 EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP-FQSIIHA----------KR 67 ++ E Y + +GSGAYG V + A+K + + F ++ + Sbjct: 33 KIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEE 92 Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDD 125 Y E+ LLK + H N+I L DVF + YLVT G I+ K + Sbjct: 93 IYNEISLLKSLDHPNIIKLFDVFEDKKYF------YLVTEFYEGGELFEQIINRHKFDEC 146 Query: 126 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV---NEDCELKILDFGLAR--HTDDEMT 180 ++ QIL G+ Y+H +I+HRD+KP N+ + N +KI+DFGL+ D ++ Sbjct: 147 DAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLR 206 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240 + T +Y APE++ YN+ D+WS G IM LL G F G + D Sbjct: 207 DRLGTAYYIAPEVLKK--KYNEKCDVWSCGVIMYILLCGYPPFGGQNDQD---------- 254 Query: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300 ++KK+ E + Y N + + A +L++ ML D +KR TA Sbjct: 255 -----IIKKV--EKGKYYFD----------FNDWKNISDEAKELIKLMLTYDYNKRCTAE 297 Query: 301 QALAHAYFAQY 311 +AL + +Y Sbjct: 298 EALNSRWIKKY 308 >3H4J-B nrPDB Length = 336 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 84/284 (29%), Positives = 137/284 (48%), Gaps = 43/284 (15%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPF--QSIIHAKRTYRELRLLKHMKHENVIGLL 87 +G G++G V A KT +VA+K +SR +S +H R RE+ LK ++H ++I L Sbjct: 17 LGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHM-RVEREISYLKLLRHPHIIKLY 75 Query: 88 DVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHSADI 146 DV T D+ +V G +L + IV+ +++T+D + QI+ ++Y H I Sbjct: 76 DVITTP------TDIVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRHKI 129 Query: 147 IHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWMHYNQTV 204 +HRDLKP NL ++++ +KI DFGL+ D + + Y APE++ ++ V Sbjct: 130 VHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGPEV 189 Query: 205 DIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQ 264 D+WS G ++ +L GR P D P L KK++S + Sbjct: 190 DVWSCGIVLYVMLVGR--LPFDDEF-----------IPN--LFKKVNS--------CVYV 226 Query: 265 MPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 MP +P A L+ +M+V D +RIT + +F Sbjct: 227 MPDF--------LSPGAQSLIRRMIVADPMQRITIQEIRRDPWF 262 >5UNP-A nrPDB Length = 369 Score = 105 bits (262), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 86/332 (25%), Positives = 154/332 (46%), Gaps = 54/332 (16%) Query: 22 ERYQNLSPVGSGAYGSVCAAFD-TKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH 80 ERY+ +S +G G +G V D + G RVA+K + + + A R E+ +L+ + Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALK-IIKNVEKYKEAARL--EINVLEKINE 90 Query: 81 EN------VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTD---DHVQFLI 131 ++ + + D F + + + L+G + +K V+ + Sbjct: 91 KDPDNKNLCVQMFDWF------DYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMA 144 Query: 132 YQILRGLKYIHSADIIHRDLKPSN-LAVNEDCEL------------------KILDFGLA 172 +Q+ + +K++H + H DLKP N L VN D EL +++DFG A Sbjct: 145 FQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA 204 Query: 173 RHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQL 232 + + V+TR YRAPE++L + ++Q D+WS+GCI+ E G TLF D+ + L Sbjct: 205 TFDHEHHSTIVSTRHYRAPEVILE-LGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHL 263 Query: 233 KLILRLVGTPGAELLKKISSE--------------SARNYIQSLTQMPKMNFANVFIGAN 278 ++ R++G + +++K + SA Y++ + P + + Sbjct: 264 AMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCK-PLRRYLTSEAEEH 322 Query: 279 PLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 DL+E ML + KR+T +AL H +FA+ Sbjct: 323 HQLFDLIESMLEYEPAKRLTLGEALQHPFFAR 354 >4YZB-A nrPDB Length = 491 Score = 105 bits (262), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 88/295 (29%), Positives = 140/295 (47%), Gaps = 43/295 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLS-RPFQSIIHAKRTYRELRLLKHMKH 80 +RY+ +G G++G V D TG AVK +S R + + +E+ LLK + H Sbjct: 30 DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDH 89 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHL-MGADL-NNIVKCQKLTDDHVQFLIYQILRGL 138 N++ L + F E+ YLVT + G +L + I+ ++ ++ +I Q+L G+ Sbjct: 90 PNIMKLYEFF------EDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGI 143 Query: 139 KYIHSADIIHRDLKPSNLAVN---EDCELKILDFGLARH--TDDEMTGYVATRWYRAPEI 193 Y+H I+HRDLKP NL + +D ++I+DFGL+ H + +M + T +Y APE+ Sbjct: 144 TYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEV 203 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 + Y++ D+WS G I+ LL+G F G + D LK + + T KK+S Sbjct: 204 LHG--TYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEP 261 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 A DL+ KML RI+A AL H + Sbjct: 262 ---------------------------AKDLIRKMLAYVPTMRISARDALEHEWL 289 >4MVF-A nrPDB Length = 506 Score = 105 bits (261), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 83/289 (28%), Positives = 140/289 (48%), Gaps = 46/289 (15%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G YG V D T A+K+ + + + R ++E+ ++K + H N++ L + Sbjct: 65 LGQGTYGCVYKGIDKVTNQLYAIKEEKK--DRLKNINRFFQEIEIMKKLDHPNIVKLYET 122 Query: 90 FTPARSLEEFNDVYLVTHLM-GADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHSADII 147 + E N +YL+ L G +L ++I++ T+ + ++ QI + Y+HS +I+ Sbjct: 123 Y------ENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIV 176 Query: 148 HRDLKPSNL---AVNEDCELKILDFGLARH--TDDEMTGYVATRWYRAPEIMLNWMHYNQ 202 HRDLKP N + N+D LKI+DFGL+++ T + T T +Y AP+++ Y++ Sbjct: 177 HRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG--KYDK 234 Query: 203 TVDIWSVGCIMAELLTGRTLFPG-TDHIDQLKLILRLVGTPGAELLKKISSESARNYIQS 261 DIWS G IM LL G F G TD+ E+LKK+ Y Sbjct: 235 KCDIWSSGVIMYTLLCGYPPFYGDTDN----------------EVLKKVKKGEFCFY--- 275 Query: 262 LTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 N + + A +L+ K+L + ++R T +AL H + Q Sbjct: 276 ---------ENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHPWITQ 315 >5XZW-A nrPDB Length = 471 Score = 103 bits (258), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 94/299 (31%), Positives = 139/299 (46%), Gaps = 56/299 (18%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 VG GA+ +V A + TG AVK +S+ + I + REL +L+ + H ++ L Sbjct: 204 VGQGAFATVKKAIERTTGKTFAVKIISKR-KVIGNMDGVTRELEVLQKLNHPRIVRLKGF 262 Query: 90 FTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ-KLTDDHVQFLIYQILRGLKYIHSADII 147 + E+ Y+V + G DL + V + +D + + QIL +KYIHS I Sbjct: 263 Y------EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGIS 316 Query: 148 HRDLKPSNLAVNED--CELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLN------- 196 HRDLKP N+ + +D +KI DFGLA+ + M + T Y APE++ Sbjct: 317 HRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSP 376 Query: 197 -----WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQL-KLILRLVGTPGAELLKKI 250 Y+ VD+WS+GC++ +LTG F G+ DQL K I R G+ LK Sbjct: 377 DEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQLYKQIGR--GSYHEGPLKDF 433 Query: 251 S-SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 SE AR++I SL Q +D + R TAA+AL H + Sbjct: 434 RISEEARDFIDSLLQ--------------------------VDPNNRSTAAKALNHPWI 466 >3GUB-A nrPDB Length = 295 Score = 103 bits (256), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 91/313 (29%), Positives = 144/313 (46%), Gaps = 52/313 (16%) Query: 7 TFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVK----KLSRPFQSI 62 T +RQE V + Y +GSG + V + TGL+ A K + ++ + Sbjct: 2 TVFRQE------NVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRG 55 Query: 63 IHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQ 120 + + RE+ +LK ++H NVI L +V+ E DV L+ L+ G + + + + Sbjct: 56 VSREDIEREVSILKEIQHPNVITLHEVY------ENKTDVILIGELVAGGELFDFLAEKE 109 Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE----DCELKILDFGLARHTD 176 LT++ + QIL G+ Y+HS I H DLKP N+ + + +KI+DFGLA D Sbjct: 110 SLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKID 169 Query: 177 --DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKL 234 +E T + APEI +N+ D+WS+G I LL+G + F Sbjct: 170 FGNEFKNIFGTPEFVAPEI-VNYEPLGLEADMWSIGVITYILLSGASPF----------- 217 Query: 235 ILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSD 294 +G E L + SA NY + F+N + LA D + ++LV D Sbjct: 218 ----LGDTKQETLANV---SAVNY-----EFEDEYFSN----TSALAKDFIRRLLVKDPK 261 Query: 295 KRITAAQALAHAY 307 KR+T +L H + Sbjct: 262 KRMTIQDSLQHPW 274 >4APC-A nrPDB Length = 350 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 107/209 (51%), Gaps = 14/209 (6%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E+Y L +G G++G T+ G + +K+++ S + + RE+ +L +MKH Sbjct: 24 EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHP 83 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVT-HLMGADLNNIVKCQK---LTDDHVQFLIYQILRG 137 N++ + F EE +Y+V + G DL + QK +D + QI Sbjct: 84 NIVQYRESF------EENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLA 137 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTGYVATRWYRAPEIM 194 LK++H I+HRD+K N+ + +D +++ DFG+AR T + + T +Y +PEI Sbjct: 138 LKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEIC 197 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLF 223 N YN DIW++GC++ EL T + F Sbjct: 198 EN-KPYNNKSDIWALGCVLYELCTLKHAF 225 >2WO6-A nrPDB Length = 382 Score = 102 bits (253), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 72/253 (28%), Positives = 131/253 (51%), Gaps = 23/253 (9%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR-----ELRLLK 76 +RY+ S +G G++G V A+D VA+K II K+ + E+RLL+ Sbjct: 54 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK--------IIKNKKAFLNQAQIEVRLLE 105 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK---CQKLTDDHVQFLIYQ 133 M + + R N + LV ++ +L ++++ + ++ + + Q Sbjct: 106 LMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQ 165 Query: 134 ILRGLKYIHSAD--IIHRDLKPSN--LAVNEDCELKILDFGLARHTDDEMTGYVATRWYR 189 + L ++ + + IIH DLKP N L + +KI+DFG + + Y+ +R+YR Sbjct: 166 MCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYR 225 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 +PE++L M Y+ +D+WS+GCI+ E+ TG LF G + +DQ+ I+ ++G P A +L + Sbjct: 226 SPEVLLG-MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQ 284 Query: 250 ISSESARNYIQSL 262 + AR + + L Sbjct: 285 --APKARKFFEKL 295 >1ZWS-A nrPDB Length = 288 Score = 101 bits (251), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 85/291 (29%), Positives = 134/291 (46%), Gaps = 48/291 (16%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVK----KLSRPFQSIIHAKRTYRELRLLKHMKHENVIG 85 +GSG + V + TGL A K + SR + + + RE+ +L+ + H NVI Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 86 LLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS 143 L DV+ E DV L+ L+ G + + + + L+++ I QIL G+ Y+H+ Sbjct: 80 LHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 144 ADIIHRDLKPSNLAVNEDC----ELKILDFGLARHTDD--EMTGYVATRWYRAPEIMLNW 197 I H DLKP N+ + + +K++DFGLA +D E T + APEI +N+ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEI-VNY 192 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 D+WS+G I LL+G + F +G E L I+S S Sbjct: 193 EPLGLEADMWSIGVITYILLSGASPF---------------LGDTKQETLANITSVS--- 234 Query: 258 YIQSLTQMPKMNFANVFIG-ANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 +F F + LA D + K+LV ++ KR+T +AL H + Sbjct: 235 ----------YDFDEEFFSHTSELAKDFIRKLLVKETRKRLTIQEALRHPW 275 >3RAW-A nrPDB Length = 381 Score = 101 bits (251), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 83/325 (25%), Positives = 143/325 (44%), Gaps = 42/325 (12%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 ERY+ + +G G +G V D G K+ R A R E+ +LK +K + Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARL--EINVLKKIKEK 108 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK---CQKLTDDHVQFLIYQILRGL 138 + + + + L+G + +K Q HV+ + YQ+ L Sbjct: 109 DKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHAL 168 Query: 139 KYIHSADIIHRDLKPSN-LAVNED----------CE--------LKILDFGLARHTDDEM 179 +++H + H DLKP N L VN + CE +++ DFG A + Sbjct: 169 RFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHH 228 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239 T VATR YR PE++L + + Q D+WS+GCI+ E G TLF ++ + L ++ +++ Sbjct: 229 TTIVATRHYRPPEVILE-LGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKIL 287 Query: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGAN--PLA-------------VDL 284 G + ++ + + + + + + + ++ N PL DL Sbjct: 288 GPIPSHMIHR--TRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDL 345 Query: 285 LEKMLVLDSDKRITAAQALAHAYFA 309 + +ML D +RIT A+AL H +FA Sbjct: 346 MRRMLEFDPAQRITLAEALLHPFFA 370 >4NIF-A nrPDB Length = 333 Score = 101 bits (251), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 98/336 (29%), Positives = 154/336 (45%), Gaps = 60/336 (17%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELR--LLKHMKHENVIGLL 87 +G G+Y T + AVK + + +KR E LL++ +H N+I L Sbjct: 16 IGVGSYSECKRCVHKATNMEYAVKVIDK-------SKRDPSEEIEILLRYGQHPNIITLK 68 Query: 88 DVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSAD 145 DV+ ++ VYLVT LM G L+ I++ + ++ F+++ I + ++Y+HS Sbjct: 69 DVY------DDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQG 122 Query: 146 IIHRDLKPSNL-----AVNEDCELKILDFGLARHTDDEMTGYVATRWYR----APEIMLN 196 ++HRDLKPSN+ + N +C L+I DFG A+ E G + T Y APE+ L Sbjct: 123 VVHRDLKPSNILYVDESGNPEC-LRICDFGFAKQLRAE-NGLLMTPCYTANFVAPEV-LK 179 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 256 Y++ DIWS+G ++ +L G T F TP E+L +I S Sbjct: 180 RQGYDEGCDIWSLGILLYTMLAGYTPFANGPS-----------DTP-EEILTRIGSGKF- 226 Query: 257 NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDD 316 + N+ V + A DL+ KML +D +R+TA Q L H + Q D Sbjct: 227 -------TLSGGNWNTV----SETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQ---KDK 272 Query: 317 EPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPP 352 P + Q + L+ + TY + S P P Sbjct: 273 LPQSQLSHQDLQ----LVKGAMAATYSALNSSKPTP 304 >4WNO-A nrPDB Length = 287 Score = 100 bits (250), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 73/244 (29%), Positives = 120/244 (49%), Gaps = 35/244 (14%) Query: 30 VGSGAYGSVC-----AAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVI 84 +G GA+ V AA D + ++ KK Q+++ +E+++LK +KHEN++ Sbjct: 26 IGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLG-----KEIKILKELKHENIV 80 Query: 85 GLLDVFTPARSLEEFNDVYLVT-HLMGADLNNIVKCQK-LTDDHVQFLIYQILRGLKYIH 142 L D E N VYLV + G DL + + + L++D ++ + QI ++ +H Sbjct: 81 ALYDF------QEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLH 134 Query: 143 SADIIHRDLKPSNLAVN---------EDCELKILDFGLARHTDDEMTG--YVATRWYRAP 191 S IIHRDLKP N+ ++ +KI DFG AR+ M + Y AP Sbjct: 135 SKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAP 194 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 E++++ HY+ D+WS+G I+ + LTG+ F + D LRL L+ I Sbjct: 195 EVIMS-QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD-----LRLFYEKNKTLVPTIP 248 Query: 252 SESA 255 E++ Sbjct: 249 RETS 252 >4PDS-A nrPDB Length = 347 Score = 100 bits (250), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 89/297 (29%), Positives = 135/297 (45%), Gaps = 54/297 (18%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 VG GA+ +V A + TG +VK +S+ + I + REL +L+ + H ++ L Sbjct: 39 VGQGAFATVKKAIERTTGKTFSVKIISKR-KVIGNMDGVTRELEVLQKLNHPRIVRLKGF 97 Query: 90 FTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ-KLTDDHVQFLIYQILRGLKYIHSADII 147 + E+ Y+V + G DL + V + +D + + QIL +KYIHS I Sbjct: 98 Y------EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGIS 151 Query: 148 HRDLKPSNLAVNED--CELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLN------- 196 HRDLKP N+ + +D +KI FGLA+ + M + T Y APE++ Sbjct: 152 HRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSP 211 Query: 197 -----WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 Y+ VD+WS+GC++ +LTG F G+ K I R G+ LK Sbjct: 212 DEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGR--GSYHEGPLKDFR 269 Query: 252 -SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 SE AR++I SL Q +D + R TAA+AL H + Sbjct: 270 ISEEARDFIDSLLQ--------------------------VDPNNRSTAAKALNHPW 300 >3MN3-A nrPDB Length = 271 Score = 100 bits (249), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 62/204 (30%), Positives = 110/204 (53%), Gaps = 10/204 (4%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK-RTYRELRLLKHMKHEN 82 YQ + +G G++G V A+ T TG +VA+K +++ + + R RE+ L+ ++H + Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPH 65 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKYI 141 +I L DV ++ +++ +V G +L + IV+ K+++ + QI+ ++Y Sbjct: 66 IIKLYDV------IKSKDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYC 119 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWMH 199 H I+HRDLKP NL ++E +KI DFGL+ D + + Y APE++ ++ Sbjct: 120 HRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLY 179 Query: 200 YNQTVDIWSVGCIMAELLTGRTLF 223 VD+WS G I+ +L R F Sbjct: 180 AGPEVDVWSCGVILYVMLCRRLPF 203 >2J90-A nrPDB Length = 304 Score = 100 bits (249), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 87/300 (29%), Positives = 142/300 (47%), Gaps = 46/300 (15%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSI----IHAKRTYRELRLL 75 V + Y+ +GSG + V TG A K + + S + + RE+ +L Sbjct: 24 VEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNIL 83 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNN-IVKCQKLTDDHVQFLIYQ 133 + ++H N+I L D+F E DV L+ L+ G +L + + + + LT+D + Q Sbjct: 84 REIRHPNIITLHDIF------ENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQ 137 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNE----DCELKILDFGLARHTD--DEMTGYVATRW 187 IL G+ Y+HS I H DLKP N+ + + + +K++DFG+A + +E T Sbjct: 138 ILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPE 197 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247 + APEI +N+ D+WS+G I LL+G + F +G E L Sbjct: 198 FVAPEI-VNYEPLGLEADMWSIGVITYILLSGASPF---------------LGETKQETL 241 Query: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 I SA NY + F+N + LA D + ++LV D +R+T AQ+L H++ Sbjct: 242 TNI---SAVNY-----DFDEEYFSN----TSELAKDFIRRLLVKDPKRRMTIAQSLEHSW 289 >2V7O-A nrPDB Length = 336 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 90/295 (30%), Positives = 131/295 (44%), Gaps = 42/295 (14%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 YQ +G GA+ V A K ++ S ++ RE R+ + +KH N+ Sbjct: 33 YQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 92 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 + L D S+ E YLV L+ G +IV + ++ I+QIL + +I Sbjct: 93 VRLHD------SISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHI 146 Query: 142 HSADIIHRDLKPSNLAVNEDCE---LKILDFGLARHTDDEMT---GYVATRWYRAPEIML 195 H DI+HRDLKP NL + C+ +K+ DFGLA E G+ T Y +PE+ L Sbjct: 147 HQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEV-L 205 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 Y + VDIW+ G I+ LL G +P DQ KL ++ A Sbjct: 206 RKDPYGKPVDIWACGVILYILLVG---YPPFWDEDQHKLYQQI---------------KA 247 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 Y P + V P A +L+ +ML ++ KRITA QAL H + Q Sbjct: 248 GAY-----DFPSPEWDTV----TPEAKNLINQMLTINPAKRITADQALKHPWVCQ 293 >4FG9-A nrPDB Length = 320 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 85/289 (29%), Positives = 138/289 (47%), Gaps = 46/289 (15%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTY--RELRLLKHMKHENVIGLL 87 +G+GA+ V A D +T VA+K +++ + K E+ +L +KH N++ L Sbjct: 26 LGTGAFSEVILAEDKRTQKLVAIKCIAK---EALEGKEGSMENEIAVLHKIKHPNIVALD 82 Query: 88 DVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSAD 145 D++ E +YL+ L+ G + IV+ T+ LI+Q+L +KY+H Sbjct: 83 DIY------ESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136 Query: 146 IIHRDLKPSNL---AVNEDCELKILDFGLARHTD--DEMTGYVATRWYRAPEIMLNWMHY 200 I+HRDLKP NL +++ED ++ I DFGL++ D ++ T Y APE++ Y Sbjct: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQ-KPY 195 Query: 201 NQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQ 260 ++ VD WS+G I LL G F + + IL+ + I S+SA+++I+ Sbjct: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDI-SDSAKDFIR 254 Query: 261 SLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 L+EK D +KR T QAL H + A Sbjct: 255 H----------------------LMEK----DPEKRFTCEQALQHPWIA 277 >6E2O-A nrPDB Length = 295 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 63/203 (31%), Positives = 106/203 (52%), Gaps = 16/203 (7%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G YG V A D +R+A+K++ P + +++ + E+ L KH+KH+N++ L Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKHLKHKNIVQYLGS 87 Query: 90 FTPARSLEEFNDVYLVTHLMGADLNNIVKCQ----KLTDDHVQFLIYQILRGLKYIHSAD 145 F+ ++ F + + G L+ +++ + K + + F QIL GLKY+H Sbjct: 88 FSENGFIKIF-----MEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQ 142 Query: 146 IIHRDLKPSNLAVNE-DCELKILDFGLARH---TDDEMTGYVATRWYRAPEIMLNW-MHY 200 I+HRD+K N+ +N LKI DFG ++ + + T Y APEI+ Y Sbjct: 143 IVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGY 202 Query: 201 NQTVDIWSVGCIMAELLTGRTLF 223 + DIWS+GC + E+ TG+ F Sbjct: 203 GKAADIWSLGCTIIEMATGKPPF 225 >4CFH-A nrPDB Length = 493 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 87/287 (30%), Positives = 131/287 (45%), Gaps = 44/287 (15%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 +G G +G V TG +VAVK L+R +S+ + RE++ LK +H ++I L Sbjct: 41 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 100 Query: 89 VF-TPARSLEEFNDVYLVT-HLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHSAD 145 V TP+ D+++V ++ G +L + I K +L + + L QIL G+ Y H Sbjct: 101 VISTPS-------DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 153 Query: 146 IIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWMHYNQT 203 ++HRDLKP N+ ++ KI DFGL+ D + + Y APE++ ++ Sbjct: 154 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPE 213 Query: 204 VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLT 263 VDIWS G I+ LL G TL DH+ L KKI + Sbjct: 214 VDIWSSGVILYALLCG-TLPFDDDHV--------------PTLFKKICD--------GIF 250 Query: 264 QMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 P+ NP + LL+ ML +D KR T H +F Q Sbjct: 251 YTPQY--------LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQ 289 >2A27-A nrPDB Length = 321 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 84/291 (28%), Positives = 134/291 (46%), Gaps = 48/291 (16%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVK----KLSRPFQSIIHAKRTYRELRLLKHMKHENVIG 85 +GSG + V + TGL A K + SR + + + RE+ +L+ + H NVI Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 86 LLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS 143 L DV+ E DV L+ L+ G + + + + L+++ I QIL G+ Y+H+ Sbjct: 80 LHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 144 ADIIHRDLKPSNLAVNEDC----ELKILDFGLARHTDD--EMTGYVATRWYRAPEIMLNW 197 I H DLKP N+ + + +K++DFGLA +D E T + APEI+ N+ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIV-NY 192 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 D+WS+G I LL+G + F +G E L I++ S Sbjct: 193 EPLGLEADMWSIGVITYILLSGASPF---------------LGDTKQETLANITAVS--- 234 Query: 258 YIQSLTQMPKMNFANVFIG-ANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 +F F + LA D + K+LV ++ KR+T +AL H + Sbjct: 235 ----------YDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPW 275 >4B6L-A nrPDB Length = 281 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 76/258 (29%), Positives = 125/258 (48%), Gaps = 29/258 (11%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVK-----KLSRPFQSIIHAKRTYRELRLLKHMKHENVI 84 +G G + A DT+TG AVK ++++P Q ++ E+ L + ++H +++ Sbjct: 17 LGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQR----EKILNEIELHRDLQHRHIV 72 Query: 85 GLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQ-KLTDDHVQFLIYQILRGLKYIH 142 F E+ +++Y+ L L +I K + L + V++ + QIL GLKY+H Sbjct: 73 RFSHHF------EDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLH 126 Query: 143 SADIIHRDLKPSNLAVNEDCELKILDFGLARH---TDDEMTGYVATRWYRAPEIMLNWMH 199 I+HRDLK N + E+ ELK+ DFGLA + T Y APE++L H Sbjct: 127 QRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGH 186 Query: 200 YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL-------VGTPGAELLKKISS 252 D+WS+GC+M LL G F D + + I ++ + P +LL I Sbjct: 187 -GPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILR 245 Query: 253 ESARNYIQSLTQMPKMNF 270 S R+ S+ Q+ + +F Sbjct: 246 ASPRDR-PSIDQILRHDF 262 >3F3Z-A nrPDB Length = 277 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 81/289 (28%), Positives = 130/289 (44%), Gaps = 46/289 (15%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G++G V A T +R A KK+ + F + R +E+ ++K + H N+I L + Sbjct: 17 IGRGSWGEVKIAVQKGTRIRRAAKKIPKYF--VEDVDRFKQEIEIMKSLDHPNIIRLYET 74 Query: 90 FTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADII 147 F E+ D+YLV L G +V + + ++ +L + Y H ++ Sbjct: 75 F------EDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNVA 128 Query: 148 HRDLKPSN---LAVNEDCELKILDFGLARH--TDDEMTGYVATRWYRAPEIMLNWMHYNQ 202 HRDLKP N L + D LK++DFGLA M V T +Y +P+++ Y Sbjct: 129 HRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEGL--YGP 186 Query: 203 TVDIWSVGCIMAELLTGRTLFPG-TDHIDQLKLILRLVGTPGAELLKKISSESARNYIQS 261 D WS G +M LL G F TD +E++ KI + Sbjct: 187 ECDEWSAGVMMYVLLCGYPPFSAPTD----------------SEVMLKIR--------EG 222 Query: 262 LTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 P+ ++ NV +P A L+ ++L +RIT+ QAL H +F + Sbjct: 223 TFTFPEKDWLNV----SPQAESLIRRLLTKSPKQRITSLQALEHEWFEK 267 >4REW-A nrPDB Length = 540 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 86/287 (29%), Positives = 131/287 (45%), Gaps = 44/287 (15%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 +G G +G V TG +VAVK L+R +S+ + RE++ LK +H ++I L Sbjct: 14 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 73 Query: 89 VF-TPARSLEEFNDVYLVT-HLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHSAD 145 V TP+ D+++V ++ G +L + I K +L + + L QIL G+ Y H Sbjct: 74 VISTPS-------DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 126 Query: 146 IIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWMHYNQT 203 ++HRDLKP N+ ++ KI DFGL+ D + + Y APE++ ++ Sbjct: 127 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPE 186 Query: 204 VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLT 263 VDIWS G I+ LL G TL DH+ L KKI + Sbjct: 187 VDIWSSGVILYALLCG-TLPFDDDHV--------------PTLFKKI--------CDGIF 223 Query: 264 QMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 P+ NP + LL+ ML +D KR + H +F Q Sbjct: 224 YTPQY--------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ 262 >3HKO-A nrPDB Length = 345 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 96/362 (26%), Positives = 158/362 (43%), Gaps = 80/362 (22%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S R Y Q ++ E+ ++Y +G G+YG V A + +T A+K +++ Sbjct: 8 SSGRENLYFQ--GGSLLELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIR 65 Query: 62 IIHAK---RTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--------- 109 I+ K R E+RL+K + H N+ L +V+ + + ++ HL+ Sbjct: 66 QINPKDVERIKTEVRLMKKLHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDD 125 Query: 110 --GADLNNIVK-----CQKLTDDHVQFLIY--------------------QILRGLKYIH 142 G ++VK C + ++ + I+ QI L Y+H Sbjct: 126 STGKCAMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLH 185 Query: 143 SADIIHRDLKPSNL--AVNEDCELKILDFGLARH----TDDE---MTGYVATRWYRAPEI 193 + I HRD+KP N + N+ E+K++DFGL++ + E MT T ++ APE+ Sbjct: 186 NQGICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEV 245 Query: 194 MLNWMH--YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 LN + Y D WS G ++ LL G FPG + D + +L KK+ Sbjct: 246 -LNTTNESYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLN----------KKLC 294 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311 E+ NY NV +PLA DLL +L + D+R A +AL H + +Q+ Sbjct: 295 FENP-NY-------------NVL---SPLARDLLSNLLNRNVDERFDAMRALQHPWISQF 337 Query: 312 HD 313 D Sbjct: 338 SD 339 >2JC6-A nrPDB Length = 334 Score = 98.6 bits (244), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 86/288 (29%), Positives = 139/288 (48%), Gaps = 44/288 (15%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR-ELRLLKHMKHENVIGLLD 88 +G+GA+ V A + TG AVK + P +++ + + E+ +L+ +KHEN++ L D Sbjct: 30 LGTGAFSEVVLAEEKATGKLFAVKCI--PKKALKGKESSIENEIAVLRKIKHENIVALED 87 Query: 89 VFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADI 146 ++ E N +YLV L+ G + IV+ T+ LI Q+L + Y+H I Sbjct: 88 IY------ESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGI 141 Query: 147 IHRDLKPSNL---AVNEDCELKILDFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYN 201 +HRDLKP NL + +E+ ++ I DFGL++ D M+ T Y APE++ Y+ Sbjct: 142 VHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQ-KPYS 200 Query: 202 QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQS 261 + VD WS+G I LL G F + + IL+ + I S+SA+++I+ Sbjct: 201 KAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDI-SDSAKDFIR- 258 Query: 262 LTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 +L+EK D +KR T QA H + A Sbjct: 259 ---------------------NLMEK----DPNKRYTCEQAARHPWIA 281 >4KS7-A nrPDB Length = 292 Score = 98.2 bits (243), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 73/289 (25%), Positives = 133/289 (46%), Gaps = 39/289 (13%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G+ G VC A + +G +VAVK + Q + + E+ +++ +H NV+ + Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQ--RRELLFNEVVIMRDYQHFNVVEMYKS 88 Query: 90 FTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHR 149 + L L+ L G L +IV +L ++ + + +L+ L Y+H+ +IHR Sbjct: 89 YLVGEELW-----VLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHR 143 Query: 150 DLKPSNLAVNEDCELKILDFGLARHTDDEM---TGYVATRWYRAPEIMLNWMHYNQTVDI 206 D+K ++ + D +K+ DFG ++ V T ++ APE++ + Y VDI Sbjct: 144 DIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL-YATEVDI 202 Query: 207 WSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP 266 WS+G ++ E++ G + + +K RL +P P Sbjct: 203 WSLGIMVIEMVDGEPPYFSDSPVQAMK---RLRDSPP----------------------P 237 Query: 267 KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPD 315 K+ ++ +P+ D LE+MLV D +R TA + L H + Q P+ Sbjct: 238 KLKNSH---KVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPE 283 >2YAB-A nrPDB Length = 361 Score = 98.2 bits (243), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 83/293 (28%), Positives = 134/293 (45%), Gaps = 48/293 (16%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVK----KLSRPFQSIIHAKRTYRELRLLKHMKHENVIG 85 +GSG + V + TGL A K + SR + + + RE+ +L+ + H N+I Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNIIT 79 Query: 86 LLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS 143 L DV+ E DV L+ L+ G + + + + L+++ I QIL G+ Y+H+ Sbjct: 80 LHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 144 ADIIHRDLKPSNLAVNEDC----ELKILDFGLARHTDD--EMTGYVATRWYRAPEIMLNW 197 I H DLKP N+ + + +K++DFGLA +D E T + APEI +N+ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEI-VNY 192 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 D+WS+G I LL+G + F +G E L I++ S Sbjct: 193 EPLGLEADMWSIGVITYILLSGASPF---------------LGDTKQETLANITAVS--- 234 Query: 258 YIQSLTQMPKMNFANVFIG-ANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 +F F + LA D + K+LV ++ KR+T +AL H + Sbjct: 235 ----------YDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >4KIK-B nrPDB Length = 677 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 70/219 (31%), Positives = 111/219 (50%), Gaps = 21/219 (9%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 WE+ ER +G+G +G+V + +TG ++A+K+ + S + +R E+++++ Sbjct: 21 WEMKER------LGTGGFGNVIRWHNQETGEQIAIKQCRQEL-SPRNRERWCLEIQIMRR 73 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVT--HLMGADL----NNIVKCQKLTDDHVQFLI 131 + H NV+ DV ++L ND+ L+ + G DL N C L + + L+ Sbjct: 74 LTHPNVVAARDVPEGMQNLAP-NDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLL 132 Query: 132 YQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL---KILDFGLARHTDDE--MTGYVATR 186 I L+Y+H IIHRDLKP N+ + + + KI+D G A+ D T +V T Sbjct: 133 SDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTL 192 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTG-RTLFP 224 Y APE +L Y TVD WS G + E +TG R P Sbjct: 193 QYLAPE-LLEQQKYTVTVDYWSFGTLAFECITGFRPFLP 230 >5JZN-A nrPDB Length = 280 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 86/311 (27%), Positives = 141/311 (45%), Gaps = 51/311 (16%) Query: 11 QELNKTIWEVP----ERYQNLSPVGSGAYGSVCAAFDTKTG----LRVAVKKLSRPFQSI 62 +E+++ +++P ERY+ +G G + V + T L++ K R + + Sbjct: 4 EEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHM 63 Query: 63 IHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADL-NNIVKCQ 120 I E+ +L+ +KH N++ L++ ++ ++YLV L+ G DL + I Sbjct: 64 IQ-----NEVSILRRVKHPNIVLLIE------EMDVPTELYLVMELVKGGDLFDAITSTN 112 Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE----DCELKILDFGLARHTD 176 K T+ ++Y + +KY+HS +I+HRD+KP NL V E LK+ DFGLA D Sbjct: 113 KYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVD 172 Query: 177 DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 + T Y APEI+ Y VDIW+ G I LL G F G+ ++ Sbjct: 173 GPLYTVCGTPTYVAPEIIAE-TGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQ 231 Query: 237 RLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKR 296 L+G P + NV + A +L+ ML++D D+R Sbjct: 232 ILMGQ---------------------VDFPSPYWDNV----SDSAKELITMMLLVDVDQR 266 Query: 297 ITAAQALAHAY 307 +A Q L H + Sbjct: 267 FSAVQVLEHPW 277 >4FIE-A nrPDB Length = 423 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 71/293 (24%), Positives = 136/293 (46%), Gaps = 41/293 (13%) Query: 26 NLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIG 85 N +G G+ G VC A +G VAVKK+ + + + E+ +++ +HENV+ Sbjct: 155 NFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVE 212 Query: 86 LLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSA 144 + + + +++++V + G L +IV ++ ++ + + +L+ L +H+ Sbjct: 213 MYNSYLVG------DELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 266 Query: 145 DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM---TGYVATRWYRAPEIMLNWMHYN 201 +IHRD+K ++ + D +K+ DFG E+ V T ++ APE +++ + Y Sbjct: 267 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYG 325 Query: 202 QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQS 261 VDIWS+G ++ E++ G + + +K+I R P + L K+S Sbjct: 326 PEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMI-RDNLPPRLKNLHKVS---------- 374 Query: 262 LTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 314 P L+++LV D +R TAA+ L H + A+ P Sbjct: 375 -----------------PSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 410 >4XBR-A nrPDB Length = 366 Score = 97.8 bits (242), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 74/299 (24%), Positives = 138/299 (46%), Gaps = 42/299 (14%) Query: 21 PERY-QNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 P Y N +G G+ G VC A +G VAVKK+ Q + + E+ +++ + Sbjct: 92 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQ--RRELLFNEVVIMRDYQ 149 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQILRGL 138 HENV+ + + + +++++V + G L +IV ++ ++ + + +L+ L Sbjct: 150 HENVVEMYNSYLVG------DELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQAL 203 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM---TGYVATRWYRAPEIML 195 +H+ +IHRD+K ++ + D +K+ DFG E+ V T ++ APE ++ Sbjct: 204 SVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LI 262 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 + + Y VDIWS+G ++ E++ G + + +K+I R P + L K+S Sbjct: 263 SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMI-RDNLPPRLKNLHKVS---- 317 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 314 P L+++LV D +R TAA+ L H + A+ P Sbjct: 318 -----------------------PSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 353 >6QAU-A nrPDB Length = 280 Score = 97.8 bits (242), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 73/249 (29%), Positives = 122/249 (48%), Gaps = 33/249 (13%) Query: 24 YQNLSPVGSGAYGSVCAA-FDTKTGLRVAVKKLSRPFQS---IIHAKRTYRELRLLKHMK 79 Y VG GA+ V KT VA+K +++ S I+ K E+++LK ++ Sbjct: 13 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGK----EIKILKELQ 68 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVT-HLMGADLNNIVKCQ-KLTDDHVQFLIYQILRG 137 HEN++ L DV E N V+LV + G DL + ++ + L++D ++ ++QI Sbjct: 69 HENIVALYDV------QELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAA 122 Query: 138 LKYIHSADIIHRDLKPSNLAVN---------EDCELKILDFGLARHTDDEMTG--YVATR 186 ++ +HS IIHRDLKP N+ ++ +KI DFG AR+ M + Sbjct: 123 MRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSP 182 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 Y APE++++ HY+ D+WS+G ++ + L G+ F D LR+ L Sbjct: 183 MYMAPEVIMS-QHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD-----LRMFYEKNRSL 236 Query: 247 LKKISSESA 255 + I E++ Sbjct: 237 MPSIPRETS 245 >2Z7Q-A nrPDB Length = 321 Score = 97.8 bits (242), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 82/268 (30%), Positives = 132/268 (49%), Gaps = 26/268 (9%) Query: 21 PERYQNLSPVGSGAYGSVCAAFDTK---TGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 P ++ L +G G++G V +G A+K L + + RT E +L Sbjct: 27 PSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILAD 86 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVT-HLMGADL-NNIVKCQKLTDDHVQFLIYQIL 135 + H V+ L F L YL+ L G DL + K T++ V+F + ++ Sbjct: 87 VNHPFVVKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 140 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-DDEMTGY--VATRWYRAPE 192 GL ++HS II+RDLKP N+ ++E+ +K+ DFGL++ D E Y T Y APE Sbjct: 141 LGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPE 200 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL-VGTPGAELLKKIS 251 + +N ++ + D WS G +M E+LTG F G D + + LIL+ +G P + Sbjct: 201 V-VNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP------QFL 253 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANP 279 S A++ +++L K N AN +G+ P Sbjct: 254 STEAQSLLRALF---KRNPANR-LGSGP 277 >2Q0N-A nrPDB Length = 301 Score = 97.4 bits (241), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 72/293 (24%), Positives = 136/293 (46%), Gaps = 41/293 (13%) Query: 26 NLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIG 85 N +G G+ G VC A +G VAVKK+ Q + + E+ +++ +HENV+ Sbjct: 33 NFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQ--RRELLFNEVVIMRDYQHENVVE 90 Query: 86 LLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSA 144 + + + +++++V + G L +IV ++ ++ + + +L+ L +H+ Sbjct: 91 MYNSYLVG------DELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 144 Query: 145 DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM---TGYVATRWYRAPEIMLNWMHYN 201 +IHRD+K ++ + D +K+ DFG E+ V T ++ APE +++ + Y Sbjct: 145 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYG 203 Query: 202 QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQS 261 VDIWS+G ++ E++ G + + +K+I R P + L K+S Sbjct: 204 PEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMI-RDNLPPRLKNLHKVS---------- 252 Query: 262 LTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 314 P L+++LV D +R TAA+ L H + A+ P Sbjct: 253 -----------------PSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 288 >4JDH-A nrPDB Length = 346 Score = 97.4 bits (241), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 72/293 (24%), Positives = 136/293 (46%), Gaps = 41/293 (13%) Query: 26 NLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIG 85 N +G G+ G VC A +G VAVKK+ Q + + E+ +++ +HENV+ Sbjct: 78 NFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQ--RRELLFNEVVIMRDYQHENVVE 135 Query: 86 LLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSA 144 + + + +++++V + G L +IV ++ ++ + + +L+ L +H+ Sbjct: 136 MYNSYLVG------DELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 189 Query: 145 DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM---TGYVATRWYRAPEIMLNWMHYN 201 +IHRD+K ++ + D +K+ DFG E+ V T ++ APE +++ + Y Sbjct: 190 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYG 248 Query: 202 QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQS 261 VDIWS+G ++ E++ G + + +K+I R P + L K+S Sbjct: 249 PEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMI-RDNLPPRLKNLHKVS---------- 297 Query: 262 LTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 314 P L+++LV D +R TAA+ L H + A+ P Sbjct: 298 -----------------PSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 333 >2F57-A nrPDB Length = 317 Score = 97.4 bits (241), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 73/291 (25%), Positives = 134/291 (46%), Gaps = 41/291 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E N +G G+ G VC A + TG +VAVKK+ Q + + E+ +++ H+ Sbjct: 45 EYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQ--RRELLFNEVVIMRDYHHD 102 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQILRGLKY 140 NV+ + + +++++V + G L +IV ++ ++ + + +LR L Y Sbjct: 103 NVVDMYSSYLVG------DELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSY 156 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM---TGYVATRWYRAPEIMLNW 197 +H+ +IHRD+K ++ + D +K+ DFG E+ V T ++ APE+ ++ Sbjct: 157 LHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEV-ISR 215 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 + Y VDIWS+G ++ E++ G + + ++ I R P + L K+SS Sbjct: 216 LPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRI-RDSLPPRVKDLHKVSS----- 269 Query: 258 YIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 V G L+ MLV + +R TA + L H + Sbjct: 270 ---------------VLRG-------FLDLMLVREPSQRATAQELLGHPFL 298 >6FD3-A nrPDB Length = 300 Score = 97.4 bits (241), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 72/290 (24%), Positives = 131/290 (45%), Gaps = 39/290 (13%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 ++Y +G GA G+V A D TG VA+K+++ Q + E+ +++ K+ Sbjct: 22 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIINEILVMRENKNP 79 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 N++ LD + L ++ +L G L ++V + + + + + L+ L ++ Sbjct: 80 NIVNYLDSYLVGDEL-----WVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFL 134 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG---YVATRWYRAPEIMLNWM 198 HS +IHRD+K N+ + D +K+ DFG E + V T ++ APE++ Sbjct: 135 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR-K 193 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY 258 Y VDIWS+G + E++ G + + + L LI GTP + +++S+ Sbjct: 194 AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIAT-NGTPELQNPERLSA------ 246 Query: 259 IQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 VF D L + L +D D+R +A + L H + Sbjct: 247 --------------VF-------RDFLNRCLEMDVDRRGSAKELLQHPFL 275 >5FG8-A nrPDB Length = 285 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 83/289 (28%), Positives = 132/289 (45%), Gaps = 42/289 (14%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G GA+ V TG A K ++ + ++ RE R+ + + H N++ L D Sbjct: 22 LGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLHD- 80 Query: 90 FTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADII 147 S++E N YLV L+ G +IV + ++ I QIL + + H ++ Sbjct: 81 -----SIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVV 135 Query: 148 HRDLKPSNLAVNEDCE---LKILDFGLARHTDDEMT---GYVATRWYRAPEIMLNWMHYN 201 HRDLKP NL + + +K+ DFGLA + G+ T Y +PE+ L Y Sbjct: 136 HRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEV-LKKEPYG 194 Query: 202 QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQS 261 ++VDIW+ G I+ LL G +P DQ +L ++ A +Y Sbjct: 195 KSVDIWACGVILYILLVG---YPPFWDEDQHRLYSQI-------------KAGAYDY--- 235 Query: 262 LTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 P + V P A +L+ +ML ++ +KRITAA+AL H + Q Sbjct: 236 ----PSPEWDTV----TPEAKNLINQMLTVNPNKRITAAEALKHPWICQ 276 >4JG6-A nrPDB Length = 355 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 93/315 (29%), Positives = 151/315 (47%), Gaps = 55/315 (17%) Query: 11 QELNKTIWEVPERYQNLSPVGSGAYGSVCA-AFDTKTGLRVAVKKLSRPFQSIIHAKRTY 69 Q+L++ + + Y+ +G G+Y SVC T + AVK + + +KR Sbjct: 24 QQLHRNSIQFTDGYEVKEDIGVGSY-SVCKRCIHKATNMEFAVKIIDK-------SKRDP 75 Query: 70 RELR--LLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDD 125 E LL++ +H N+I L DV+ + VY+VT LM G L+ I++ + ++ Sbjct: 76 TEEIEILLRYGQHPNIITLKDVYDDGKY------VYVVTELMKGGELLDKILRQKFFSER 129 Query: 126 HVQFLIYQILRGLKYIHSADIIHRDLKPSN-LAVNEDC---ELKILDFGLARHTDDEMTG 181 +++ I + ++Y+H+ ++HRDLKPSN L V+E ++I DFG A+ E G Sbjct: 130 EASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAE-NG 188 Query: 182 YVATRWYR----APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFP-GTDHIDQLKLIL 236 + T Y APE+ L Y+ DIWS+G ++ +LTG T F G D D + IL Sbjct: 189 LLMTPCYTANFVAPEV-LERQGYDAACDIWSLGVLLYTMLTGYTPFANGPD--DTPEEIL 245 Query: 237 RLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKR 296 +G+ L + Y S++ K DL+ KML +D +R Sbjct: 246 ARIGSGKFSL--------SGGYWNSVSDTAK---------------DLVSKMLHVDPHQR 282 Query: 297 ITAAQALAHAYFAQY 311 +TAA L H + + Sbjct: 283 LTAALVLRHPWIVHW 297 >2X4F-A nrPDB Length = 373 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 82/289 (28%), Positives = 136/289 (47%), Gaps = 43/289 (14%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G +G V +T TGL++A K + + + + E+ ++ + H N+I L D Sbjct: 97 LGGGRFGQVHKCEETATGLKLAAKIIKT--RGMKDKEEVKNEISVMNQLDHANLIQLYDA 154 Query: 90 FTPARSLEEFNDVYLVTHLM-GADLNN--IVKCQKLTDDHVQFLIYQILRGLKYIHSADI 146 F E ND+ LV + G +L + I + LT+ + QI G++++H I Sbjct: 155 F------ESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYI 208 Query: 147 IHRDLKPSN-LAVNEDC-ELKILDFGLARHTD--DEMTGYVATRWYRAPEIMLNWMHYNQ 202 +H DLKP N L VN D ++KI+DFGLAR +++ T + APE+ +N+ + Sbjct: 209 LHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEV-VNYDFVSF 267 Query: 203 TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSL 262 D+WSVG I LL+G + F G + + L IL E + IS E Sbjct: 268 PTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEE--------- 318 Query: 263 TQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311 A + + K+L+ + RI+A++AL H + + + Sbjct: 319 ------------------AKEFISKLLIKEKSWRISASEALKHPWLSDH 349 >3BHH-A nrPDB Length = 295 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 87/297 (29%), Positives = 131/297 (44%), Gaps = 42/297 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 + YQ +G GA+ V TG A K ++ S ++ RE R+ + +KH Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 63 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLK 139 N++ L D S+ E YLV L+ G +IV + ++ I QIL + Sbjct: 64 NIVRLHD------SISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVL 117 Query: 140 YIHSADIIHRDLKPSNLAVNEDCE---LKILDFGLARHTDDEMT---GYVATRWYRAPEI 193 + H ++HRDLKP NL + C+ +K+ DFGLA + G+ T Y +PE+ Sbjct: 118 HCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 177 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 L Y + VDIW+ G I+ LL G +P DQ KL ++ GA Sbjct: 178 -LRKEAYGKPVDIWACGVILYILLVG---YPPFWDEDQHKLYQQI--KAGA--------- 222 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 P + V P A +L+ +ML ++ KRITA +AL H + Q Sbjct: 223 ---------YDFPSPEWDTV----TPEAKNLINQMLTINPAKRITAHEALKHPWVCQ 266 >4RED-A nrPDB Length = 351 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 86/287 (29%), Positives = 130/287 (45%), Gaps = 44/287 (15%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 +G G +G V TG VAVK L+R +S+ + RE++ LK +H ++I L Sbjct: 22 LGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 81 Query: 89 VF-TPARSLEEFNDVYLVT-HLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHSAD 145 V TP+ D+++V ++ G +L + I K +L + + L QIL G+ Y H Sbjct: 82 VISTPS-------DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 134 Query: 146 IIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWMHYNQT 203 ++HRDLKP N+ ++ KI DFGL+ D + + Y APE++ ++ Sbjct: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPE 194 Query: 204 VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLT 263 VDIWS G I+ LL G TL DH+ L KKI + Sbjct: 195 VDIWSSGVILYALLCG-TLPFDDDHV--------------PTLFKKIC--------DGIF 231 Query: 264 QMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 P+ NP + LL+ ML +D KR + H +F Q Sbjct: 232 YTPQY--------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ 270 >2VN9-A nrPDB Length = 301 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 87/297 (29%), Positives = 132/297 (44%), Gaps = 42/297 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 + YQ +G GA+ V TG A K ++ S ++ RE R+ + +KH Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 63 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLK 139 N++ L D S+ E YLV L+ G +IV + ++ I QIL + Sbjct: 64 NIVRLHD------SISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 117 Query: 140 YIHSADIIHRDLKPSNL---AVNEDCELKILDFGLARHTDDEMT---GYVATRWYRAPEI 193 + H I+HRDLKP NL + ++ +K+ DFGLA + G+ T Y +PE+ Sbjct: 118 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 177 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 L Y + VD+W+ G I+ LL G +P DQ +L ++ Sbjct: 178 -LRKDPYGKPVDMWACGVILYILLVG---YPPFWDEDQHRLYQQI--------------- 218 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 A Y P + V P A DL+ KML ++ KRITA++AL H + Q Sbjct: 219 KAGAY-----DFPSPEWDTV----TPEAKDLINKMLTINPAKRITASEALKHPWICQ 266 >5D9K-A nrPDB Length = 330 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 85/279 (30%), Positives = 140/279 (50%), Gaps = 32/279 (11%) Query: 21 PERYQNLSPVGSGAYGSV-----CAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLL 75 P +++ L +G G++G V + D + A+K L + + RT E +L Sbjct: 29 PSQFELLKVLGQGSFGKVFLVKKISGSDARQ--LYAMKVLKKATLKVRDRVRTKMERDIL 86 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVT-HLMGADL-NNIVKCQKLTDDHVQFLIYQ 133 + H ++ L F L YL+ L G DL + K T++ V+F + + Sbjct: 87 VEVNHPFIVKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAE 140 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-DDEMTGY--VATRWYRA 190 + L ++HS II+RDLKP N+ ++E+ +K+ DFGL++ + D E Y T Y A Sbjct: 141 LALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMA 200 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL-VGTPGAELLKK 249 PE+ +N + Q+ D WS G +M E+LTG F G D + + +IL+ +G P + Sbjct: 201 PEV-VNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMP-----QF 254 Query: 250 ISSESARNYIQSLTQMP-KMNFANVFIGANPLAVDLLEK 287 +S E+ QSL +M K N AN +GA P V+ +++ Sbjct: 255 LSPEA-----QSLLRMLFKRNPANR-LGAGPDGVEEIKR 287 >3Q53-A nrPDB Length = 306 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 69/290 (23%), Positives = 131/290 (45%), Gaps = 39/290 (13%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 ++Y +G GA G+V A D TG VA+++++ Q + E+ +++ K+ Sbjct: 21 KKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMN--LQQQPKKELIINEILVMRENKNP 78 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 N++ LD + L ++ +L G L ++V + + + + + L+ L+++ Sbjct: 79 NIVNYLDSYLVGDEL-----WVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFL 133 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG---YVATRWYRAPEIMLNWM 198 HS +IHRD+K N+ + D +K+ DFG E + V T ++ APE++ Sbjct: 134 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR-K 192 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY 258 Y VDIWS+G + E++ G + + + L LI GTP + +K+S+ Sbjct: 193 AYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIAT-NGTPELQNPEKLSA------ 245 Query: 259 IQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 + D L + L +D +KR +A + + H + Sbjct: 246 ---------------------IFRDFLNRCLEMDVEKRGSAKELIQHQFL 274 >4UZD-A nrPDB Length = 287 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 71/240 (29%), Positives = 110/240 (45%), Gaps = 20/240 (8%) Query: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSRP---FQSIIHAKRTYRELRLLKHMKHENVIG 85 P+G G +G+V A + ++ +A+K L + + H R RE+ + H++H N++ Sbjct: 15 PLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLR--REVEIQSHLRHPNILR 72 Query: 86 LLDVFTPARSLEEFNDVYLVTHL--MGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS 143 L F A VYL+ +G + K K + I ++ L Y HS Sbjct: 73 LYGYFHDA------TRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS 126 Query: 144 ADIIHRDLKPSNLAVNEDCELKILDFGLARHT-DDEMTGYVATRWYRAPEIMLNWMHYNQ 202 +IHRD+KP NL + ELKI DFG + H T T Y PE++ MH ++ Sbjct: 127 KRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMH-DE 185 Query: 203 TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSL 262 VD+WS+G + E L G+ F + + K I R+ T +E AR+ I L Sbjct: 186 KVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFT-----FPDFVTEGARDLISRL 240 >5KZ7-A nrPDB Length = 346 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 70/262 (26%), Positives = 125/262 (47%), Gaps = 19/262 (7%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 Y+ L +G G + V A TG VAVK + + + ++ +RE+R++K + H N+ Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 94 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 + L +V ++L YLV G + +V ++ + + QI+ ++Y Sbjct: 95 VKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 148 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVATRWYRAPEIMLNWMH 199 H I+HRDLK NL ++ D +KI DFG + +++ + + Y APE+ + Sbjct: 149 HQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKY 208 Query: 200 YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR-------LVGTPGAELLKK--I 250 VD+WS+G I+ L++G F G + + + +LR + T LLKK I Sbjct: 209 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLI 268 Query: 251 SSESARNYIQSLTQMPKMNFAN 272 + S R ++ + + MN + Sbjct: 269 LNPSKRGTLEQIMKDRWMNVGH 290 >2QNJ-A nrPDB Length = 328 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 107/218 (49%), Gaps = 10/218 (4%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 Y+ L +G G + V A TG VA+K + + + ++ +RE+R++K + H N+ Sbjct: 14 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 73 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 + L +V ++L YL+ G + +V ++ + + QI+ ++Y Sbjct: 74 VKLFEVIETEKTL------YLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 127 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVATRWYRAPEIMLNWMH 199 H I+HRDLK NL ++ D +KI DFG + ++ + + Y APE+ + Sbjct: 128 HQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKY 187 Query: 200 YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 VD+WS+G I+ L++G F G + + + +LR Sbjct: 188 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 225 >2VZ6-A nrPDB Length = 313 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 85/295 (28%), Positives = 130/295 (44%), Gaps = 42/295 (14%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 YQ +G GA+ V G A K ++ S ++ RE R+ + +KH N+ Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 + L D S+ E YL+ L+ G +IV + ++ I QIL + + Sbjct: 84 VRLHD------SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 137 Query: 142 HSADIIHRDLKPSNLAVN---EDCELKILDFGLARHTDDEMT---GYVATRWYRAPEIML 195 H ++HRDLKP NL + + +K+ DFGLA + E G+ T Y +PE+ L Sbjct: 138 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV-L 196 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 Y + VD+W+ G I+ LL G +P DQ +L ++ GA Sbjct: 197 RKDPYGKPVDLWACGVILYILLVG---YPPFWDEDQHRLYQQI--KAGA----------- 240 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 P + V P A DL+ KML ++ KRITAA+AL H + + Sbjct: 241 -------YDFPSPEWDTV----TPEAKDLINKMLTINPSKRITAAEALKHPWISH 284 >5U6Y-A nrPDB Length = 461 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 85/295 (28%), Positives = 130/295 (44%), Gaps = 42/295 (14%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 YQ +G GA+ V G A K ++ S ++ RE R+ + +KH N+ Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 + L D S+ E YL+ L+ G +IV + ++ I QIL + + Sbjct: 62 VRLHD------SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 115 Query: 142 HSADIIHRDLKPSNLAVN---EDCELKILDFGLARHTDDEMT---GYVATRWYRAPEIML 195 H ++HRDLKP NL + + +K+ DFGLA + E G+ T Y +PE+ L Sbjct: 116 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV-L 174 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 Y + VD+W+ G I+ LL G +P DQ +L ++ A Sbjct: 175 RKDPYGKPVDLWACGVILYILLVG---YPPFWDEDQHRLYQQI---------------KA 216 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 Y P + V P A DL+ KML ++ KRITAA+AL H + + Sbjct: 217 GAY-----DFPSPEWDTV----TPEAKDLINKMLTINPSKRITAAEALKHPWISH 262 >5ES1-A nrPDB Length = 328 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 107/218 (49%), Gaps = 10/218 (4%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 Y+ L +G G + V A TG VA+K + + + ++ +RE+R++K + H N+ Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI 76 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLMGAD--LNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 + L +V ++L YLV A + +V ++ + + QI+ + Y Sbjct: 77 VKLFEVIETEKTL------YLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYC 130 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVATRWYRAPEIMLNWMH 199 H +I+HRDLK NL ++ + +KI DFG + ++ + + Y APE+ + Sbjct: 131 HQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKY 190 Query: 200 YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 VDIWS+G I+ L++G F G + + + +LR Sbjct: 191 DGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLR 228 >1S9I-A nrPDB Length = 354 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 63/207 (30%), Positives = 103/207 (49%), Gaps = 10/207 (4%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 ++ +S +G+G G V +GL +A K + + I + REL++L + Sbjct: 18 FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIR-NQIIRELQVLHECNSPYI 76 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK-CQKLTDDHVQFLIYQILRGLKYIH 142 +G F + + H+ G L+ ++K +++ ++ + + +LRGL Y+ Sbjct: 77 VGFYGAFYSDGEIS-----ICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLR 131 Query: 143 SA-DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT-GYVATRWYRAPEIMLNWMHY 200 I+HRD+KPSN+ VN E+K+ DFG++ D M +V TR Y APE L HY Sbjct: 132 EKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPE-RLQGTHY 190 Query: 201 NQTVDIWSVGCIMAELLTGRTLFPGTD 227 + DIWS+G + EL GR P D Sbjct: 191 SVQSDIWSMGLSLVELAVGRYPIPPPD 217 >3KK8-A nrPDB Length = 284 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 85/281 (30%), Positives = 130/281 (46%), Gaps = 41/281 (14%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G GA+ V TGL A K ++ S ++ RE R+ + ++H N++ L D Sbjct: 14 LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHD- 72 Query: 90 FTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADII 147 S++E + YLV L+ G +IV + ++ I QIL + Y HS I+ Sbjct: 73 -----SIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIV 127 Query: 148 HRDLKPSNLAVNEDCE---LKILDFGLARHTDDEMT--GYVATRWYRAPEIMLNWMHYNQ 202 HR+LKP NL + + +K+ DFGLA +D G+ T Y +PE+ L Y++ Sbjct: 128 HRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEV-LKKDPYSK 186 Query: 203 TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSL 262 VDIW+ G I+ LL G +P DQ +L ++ A +Y Sbjct: 187 PVDIWACGVILYILLVG---YPPFWDEDQHRLYAQI-------------KAGAYDY---- 226 Query: 263 TQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQAL 303 P + V P A L++ ML ++ KRITA QAL Sbjct: 227 ---PSPEWDTV----TPEAKSLIDSMLTVNPKKRITADQAL 260 >6C9D-A nrPDB Length = 459 Score = 95.1 bits (235), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 107/218 (49%), Gaps = 10/218 (4%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 Y+ +G G + V A TG VAVK + + + ++ +RE+R++K + H N+ Sbjct: 23 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 82 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 + L +V ++L YLV G + +V ++ + + QI+ ++Y Sbjct: 83 VKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 136 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVATRWYRAPEIMLNWMH 199 H I+HRDLK NL ++ D +KI DFG + +++ + + Y APE+ + Sbjct: 137 HQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKY 196 Query: 200 YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 VD+WS+G I+ L++G F G + + + +LR Sbjct: 197 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 234 >4I6B-A nrPDB Length = 308 Score = 95.1 bits (235), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 67/219 (30%), Positives = 110/219 (50%), Gaps = 27/219 (12%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVK-----KLSRPFQSIIHAKRTYRELRLLK 76 +RY +G G + D A K ++S+P Q ++ +E+ L + Sbjct: 28 KRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQR----EKIDKEIELHR 83 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVY-LVTHLMGADLNNIVKCQK-LTDDHVQFLIYQI 134 + H++V+ F E+ ++Y L+ + + +I+K +K LT+ V++ + QI Sbjct: 84 ILHHKHVVQFYHYF------EDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQI 137 Query: 135 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA------RHTDDEMTGYVATRWY 188 + GLKY+H +I+HRDLK N +NE ELK+ DFGLA H + G T Y Sbjct: 138 VSGLKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICG---TPNY 194 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTD 227 +PE+ LN + DIW++GC+M +L GR F T+ Sbjct: 195 LSPEV-LNKQGHGAESDIWALGCVMYTMLLGRPPFETTN 232 >2HAK-A nrPDB Length = 328 Score = 94.7 bits (234), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 107/218 (49%), Gaps = 10/218 (4%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 Y+ +G G + V A TG VAVK + + + ++ +RE+R++K + H N+ Sbjct: 17 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 76 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 + L +V ++L YLV G + +V ++ + + QI+ ++Y Sbjct: 77 VKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 130 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVATRWYRAPEIMLNWMH 199 H I+HRDLK NL ++ D +KI DFG + +++ + + Y APE+ + Sbjct: 131 HQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKY 190 Query: 200 YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 VD+WS+G I+ L++G F G + + + +LR Sbjct: 191 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 228 >2BDW-A nrPDB Length = 362 Score = 94.7 bits (234), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 86/281 (30%), Positives = 132/281 (46%), Gaps = 41/281 (14%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G GA+ V TGL A K ++ S ++ RE R+ + ++H N++ L D Sbjct: 37 LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHD- 95 Query: 90 FTPARSLEEFNDVYLVTHLM-GADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHSADII 147 S++E + YLV L+ G +L +IV + ++ I QIL + Y HS I+ Sbjct: 96 -----SIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIV 150 Query: 148 HRDLKPSNLAVNEDCE---LKILDFGLARHTDDEMT--GYVATRWYRAPEIMLNWMHYNQ 202 HR+LKP NL + + +K+ DFGLA +D G+ T Y +PE+ L Y++ Sbjct: 151 HRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEV-LKKDPYSK 209 Query: 203 TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSL 262 VDIW+ G I+ LL G +P DQ +L ++ A +Y Sbjct: 210 PVDIWACGVILYILLVG---YPPFWDEDQHRLYAQI-------------KAGAYDY---- 249 Query: 263 TQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQAL 303 P + V P A L++ ML ++ KRITA QAL Sbjct: 250 ---PSPEWDTV----TPEAKSLIDSMLTVNPKKRITADQAL 283 >4WB7-A nrPDB Length = 405 Score = 94.7 bits (234), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 114/218 (52%), Gaps = 21/218 (9%) Query: 18 WEVP-------ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR--- 67 WE P ++++ + +G+G++G V +TG A+K L + Q ++ K+ Sbjct: 85 WESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDK--QKVVKLKQIEH 142 Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDD 125 T E R+L+ + ++ L S ++ +++Y+V + G +++ + + ++ Sbjct: 143 TLNEKRILQAVNFPFLVKL------EFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP 196 Query: 126 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVAT 185 H +F QI+ +Y+HS D+I+RDLKP NL +++ +++ DFG A+ T Sbjct: 197 HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGT 256 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLF 223 Y APEI+L+ YN+ VD W++G ++ E+ G F Sbjct: 257 PEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPF 293 >4C0T-A nrPDB Length = 974 Score = 94.4 bits (233), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 85/324 (26%), Positives = 146/324 (45%), Gaps = 63/324 (19%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM--KHENVIGLL 87 +G G+Y +V A D TG + AVK L + + II K+ + + + KH + N +G++ Sbjct: 274 LGEGSYSTVILATDKITGKQYAVKVLDK--RHIIKEKKV-KYVNIEKHALNRLSNRLGVI 330 Query: 88 DVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSAD 145 ++ + ++ + +Y V G L I + L ++ + QIL +KY+H Sbjct: 331 SLYF---TFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHDNG 387 Query: 146 IIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTGY---------VATRWYRAPEI 193 +IHRDLKP N+ +++ ++I DFG AR +DE Y V T Y +PE+ Sbjct: 388 VIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPEL 447 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 + N + + D+W+ GCI+ +++ G+ F T Sbjct: 448 LEN-KYCGKPGDVWAFGCIIYQMIAGKPPFKAT--------------------------- 479 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAV-DLLEKMLVLDSDKRITAAQALAHAYFAQ-- 310 N + ++ K+ FA F P + DL++K+LVL +R T + H +F Sbjct: 480 ---NEYLTFQKITKLQFA--FSAGFPTIIRDLIKKILVLQPSRRATIPEIQKHYFFQSVD 534 Query: 311 YHDPD-----DEPVADPYDQSFES 329 + D D D P PY + +S Sbjct: 535 FKDFDSIWLSDPPEIGPYKMTAKS 558 >5TQX-A nrPDB Length = 655 Score = 94.4 bits (233), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 70/217 (32%), Positives = 107/217 (49%), Gaps = 21/217 (9%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 WE+ ER +G+G +G+VC + L++A+K R S + +R E++++K Sbjct: 10 WEMRER------LGTGGFGNVCLYQHRELDLKIAIKS-CRLELSTKNRERWCHEIQIMKK 62 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVT--HLMGADLNNIVK----CQKLTDDHVQFLI 131 + H NV+ DV L +DV L+ + G DL ++ C L + + L+ Sbjct: 63 LNHANVVKACDVPEELNIL--IHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLL 120 Query: 132 YQILRGLKYIHSADIIHRDLKPSNLA---VNEDCELKILDFGLARHTD--DEMTGYVATR 186 I G++Y+H IIHRDLKP N+ V KI+D G A+ D + T +V T Sbjct: 121 SDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTL 180 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLF 223 Y APE+ N Y TVD WS G ++ E + G F Sbjct: 181 QYLAPELFEN-KPYTATVDYWSFGTMVFECIAGYRPF 216 >6CMJ-A nrPDB Length = 321 Score = 94.0 bits (232), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 108/209 (51%), Gaps = 19/209 (9%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRP---------FQSIIHAKRTYRELRLLKHMKH 80 +G G+YG V A++ A+K LS+ Q ++ Y+E+ +LK + H Sbjct: 42 IGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEIAILKKLDH 101 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQKLTDDHVQFLIYQILRGLK 139 NV+ L++V + +Y+V L+ + + + L++D +F +++G++ Sbjct: 102 PNVVKLVEVLDDPNE----DHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIE 157 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLA---RHTDDEMTGYVATRWYRAPEIM-- 194 Y+H IIHRD+KPSNL V ED +KI DFG++ + +D ++ V T + APE + Sbjct: 158 YLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSE 217 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLF 223 + + +D+W++G + + G+ F Sbjct: 218 TRKIFSGKALDVWAMGVTLYCFVFGQCPF 246 >3DTC-A nrPDB Length = 271 Score = 94.0 bits (232), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 74/215 (34%), Positives = 105/215 (48%), Gaps = 24/215 (11%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYR-ELRLLKHMKHENVIGLL 87 +G G +G V AF G VAVK P + I R E +L +KH N+I L Sbjct: 15 IGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 72 Query: 88 DVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS---A 144 V L+E N ++ G LN ++ +++ D + QI RG+ Y+H Sbjct: 73 GV-----CLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIV 127 Query: 145 DIIHRDLKPSNLAVNEDCE--------LKILDFGLAR--HTDDEMTGYVATRWYRAPEIM 194 IIHRDLK SN+ + + E LKI DFGLAR H +M+ A W APE++ Sbjct: 128 PIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYAWM-APEVI 186 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI 229 M +++ D+WS G ++ ELLTG F G D + Sbjct: 187 RASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGL 220 >1FOT-A nrPDB Length = 318 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 112/215 (52%), Gaps = 8/215 (3%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ-SIIHAKRTYRELRLLKHMKHEN 82 +Q L +G+G++G V G A+K L + + + T E +L + H Sbjct: 8 FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPF 67 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQKLTDDHVQFLIYQILRGLKYI 141 +I + F A+ + ++ ++ G +L +++ K Q+ + +F ++ L+Y+ Sbjct: 68 IIRMWGTFQDAQQI-----FMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYL 122 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYN 201 HS DII+RDLKP N+ ++++ +KI DFG A++ D T Y APE+ ++ YN Sbjct: 123 HSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEV-VSTKPYN 181 Query: 202 QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 +++D WS G ++ E+L G T F ++ + + IL Sbjct: 182 KSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKIL 216 >5X3F-B nrPDB Length = 393 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 112/214 (52%), Gaps = 21/214 (9%) Query: 18 WEVP-------ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR--- 67 WE P +++ + +G+G++G V ++G A+K L + Q ++ K+ Sbjct: 73 WETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDK--QKVVKLKQIEH 130 Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDD 125 T E R+L+ + ++ L S ++ +++Y+V + G +++ + + ++ Sbjct: 131 TLNEKRILQAVNFPFLVKL------EFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEP 184 Query: 126 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVAT 185 H +F QI+ +Y+HS D+I+RDLKP NL +++ +++ DFG A+ T Sbjct: 185 HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGT 244 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTG 219 Y APEI+L+ YN+ VD W++G ++ E+ G Sbjct: 245 PEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAG 277 >5DYK-A nrPDB Length = 853 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 65/211 (30%), Positives = 112/211 (53%), Gaps = 17/211 (8%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN----VIG 85 +G G +G+V T +R A+K +S+ +SII+ + ++L + + EN +I Sbjct: 547 IGRGTFGTVKLVHHKPTKIRYALKCVSK--RSIINLNQQ-NNIKLEREITAENDHPFIIR 603 Query: 86 LLDVFTPARSLEEFNDVYLVTHLM-GADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHS 143 L+ F ++ Y +T L+ G +L + I K L+ QF + I+ ++Y+H Sbjct: 604 LVRTFKDSKYF------YFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHE 657 Query: 144 ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQT 203 +I++RDLKP N+ +++ +K++DFG A+ V T Y APE++L Y T Sbjct: 658 RNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILG-KGYGCT 716 Query: 204 VDIWSVGCIMAELLTGRTLFPGTDHIDQLKL 234 VDIW++G + E + G F G D DQL++ Sbjct: 717 VDIWALGICLYEFICGPLPF-GNDEEDQLEI 746 >3D2K-A nrPDB Length = 272 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 75/285 (26%), Positives = 124/285 (43%), Gaps = 46/285 (16%) Query: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSRP---FQSIIHAKRTYRELRLLKHMKHENVIG 85 P+G G +G+V A + ++ +A+K L + + H R RE+ + H++H N++ Sbjct: 19 PLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLR--REVEIQSHLRHPNILR 76 Query: 86 LLDVFTPARSLEEFNDVYLVTHL--MGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS 143 L F A VYL+ +G + K + + I ++ L Y HS Sbjct: 77 LYGYFHDA------TRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYCHS 130 Query: 144 ADIIHRDLKPSNLAVNEDCELKILDFGLARHT-DDEMTGYVATRWYRAPEIMLNWMHYNQ 202 +IHRD+KP NL + + ELKI DFG + H T T Y PE++ MH ++ Sbjct: 131 KRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMH-DE 189 Query: 203 TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSL 262 VD+WS+G + E L G F + + + I R+ T +E AR Sbjct: 190 KVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFT-----FPDFVTEGAR------ 238 Query: 263 TQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 DL+ ++L ++ +R+T A+ L H + Sbjct: 239 --------------------DLISRLLKHNASQRLTLAEVLEHPW 263 >5FET-A nrPDB Length = 847 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 66/211 (31%), Positives = 113/211 (53%), Gaps = 17/211 (8%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN----VIG 85 +G G +G+V T +R A+K +S+ +SII + ++L + + EN +I Sbjct: 541 IGRGTFGTVKLVHHKPTQIRYALKCVSK--RSIISLNQQ-NNIKLEREITAENDHPFIIR 597 Query: 86 LLDVFTPARSLEEFNDVYLVTHLM-GADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHS 143 L+ R+ ++ N Y +T L+ G +L + I K L+ QF + I+ ++Y+H Sbjct: 598 LV------RTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHE 651 Query: 144 ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQT 203 +I++RDLKP N+ +++ +K++DFG A+ V T Y APE++L Y T Sbjct: 652 RNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTLVGTPHYMAPEVILG-KGYGCT 710 Query: 204 VDIWSVGCIMAELLTGRTLFPGTDHIDQLKL 234 VDIW++G + E + G F G D DQL++ Sbjct: 711 VDIWALGVCLYEFICGPLPF-GNDQEDQLEI 740 >3SOA-A nrPDB Length = 444 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 84/297 (28%), Positives = 130/297 (43%), Gaps = 42/297 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E YQ +G GA+ V G A ++ S ++ RE R+ + +KH Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHP 70 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLK 139 N++ L D S+ E YL+ L+ G +IV + ++ I QIL + Sbjct: 71 NIVRLHD------SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVL 124 Query: 140 YIHSADIIHRDLKPSNLAVN---EDCELKILDFGLARHTDDEMT---GYVATRWYRAPEI 193 + H ++HR+LKP NL + + +K+ DFGLA + E G+ T Y +PE+ Sbjct: 125 HCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV 184 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 L Y + VD+W+ G I+ LL G +P DQ +L ++ Sbjct: 185 -LRKDPYGKPVDLWACGVILYILLVG---YPPFWDEDQHRLYQQI--------------- 225 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 A Y P + V P A DL+ KML ++ KRITAA+AL H + + Sbjct: 226 KAGAY-----DFPSPEWDTV----TPEAKDLINKMLTINPSKRITAAEALKHPWISH 273 >3QA8-A nrPDB Length = 676 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 71/219 (32%), Positives = 108/219 (49%), Gaps = 21/219 (9%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 WE+ ER +G+G +G V TG +VA+K+ + S + +R E++++K Sbjct: 16 WEMKER------LGTGGFGYVLRWIHQDTGEQVAIKQCRQEL-SPKNRERWCLEIQIMKK 68 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVT--HLMGADL----NNIVKCQKLTDDHVQFLI 131 + H NV+ +V + L ND+ L+ + G DL N C L + ++ L+ Sbjct: 69 LNHPNVVSAREVPDGLQKLAP-NDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLL 127 Query: 132 YQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL---KILDFGLARHTD--DEMTGYVATR 186 I L+Y+H IIHRDLKP N+ + + KI+D G A+ D + T +V T Sbjct: 128 SDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTL 187 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTG-RTLFP 224 Y APE +L Y TVD WS G + E +TG R P Sbjct: 188 QYLAPE-LLEQKKYTVTVDYWSFGTLAFECITGFRPFLP 225 >4EQM-A nrPDB Length = 294 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 64/214 (29%), Positives = 110/214 (51%), Gaps = 16/214 (7%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHA-KRTYRELRLLKHM 78 + ERY+ + +G G +V A DT ++VA+K + P + KR RE+ + Sbjct: 9 INERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQL 68 Query: 79 KHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGADLNNIVKCQK-LTDDHVQFLIYQIL 135 H+N++ ++DV +E +D Y ++ ++ G L+ ++ L+ D QIL Sbjct: 69 SHQNIVSMIDV-------DEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQIL 121 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTGYV-ATRWYRAP 191 G+K+ H I+HRD+KP N+ ++ + LKI DFG+A+ T T +V T Y +P Sbjct: 122 DGIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSP 181 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPG 225 E ++ DI+S+G ++ E+L G F G Sbjct: 182 E-QAKGEATDECTDIYSIGIVLYEMLVGEPPFNG 214 >4UY9-A nrPDB Length = 323 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 73/215 (33%), Positives = 104/215 (48%), Gaps = 24/215 (11%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYR-ELRLLKHMKHENVIGLL 87 +G G +G V AF G VAVK P + I R E +L +KH N+I L Sbjct: 17 IGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 74 Query: 88 DVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS---A 144 V L+E N ++ G LN ++ +++ D + QI RG+ Y+H Sbjct: 75 GV-----CLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIV 129 Query: 145 DIIHRDLKPSNLAVNEDCE--------LKILDFGLAR--HTDDEMTGYVATRWYRAPEIM 194 IIHRDLK SN+ + + E LKI DFGLAR H +M+ W APE++ Sbjct: 130 PIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWM-APEVI 188 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI 229 M +++ D+WS G ++ ELLTG F G D + Sbjct: 189 RASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGL 222 >2JDO-A nrPDB Length = 342 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 64/221 (28%), Positives = 112/221 (50%), Gaps = 17/221 (7%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK----RTYRELRLLKHMK 79 + L +G G +G V + TG A+K L + +I AK T E R+L++ + Sbjct: 12 FDYLKLLGKGTFGKVILVREKATGRYYAMKILRK---EVIIAKDEVAHTVTESRVLQNTR 68 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLN-NIVKCQKLTDDHVQFLIYQILRGL 138 H + L F L +++ + G +L ++ + + T++ +F +I+ L Sbjct: 69 HPFLTALKYAFQTHDRL-----CFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSAL 123 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVATRWYRAPEIML 195 +Y+HS D+++RD+K NL +++D +KI DFGL + + M + T Y APE++ Sbjct: 124 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 183 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 + Y + VD W +G +M E++ GR F DH +LIL Sbjct: 184 D-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL 223 >4JXF-A nrPDB Length = 266 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 64/215 (29%), Positives = 110/215 (51%), Gaps = 14/215 (6%) Query: 16 TIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKL-SRPFQSIIHAKRTYRELRL 74 I E E ++ + +G G++ V A TGL VA+K + + +R E+++ Sbjct: 1 CIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKI 60 Query: 75 LKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVK--CQKLTDDHVQFLI 131 +KH +++ L + F E+ N VYLV + ++N +K + +++ + + Sbjct: 61 HCQLKHPSILELYNYF------EDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFM 114 Query: 132 YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA---RHTDDEMTGYVATRWY 188 +QI+ G+ Y+HS I+HRDL SNL + + +KI DFGLA + ++ T Y Sbjct: 115 HQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNY 174 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLF 223 +PEI H ++ D+WS+GC+ LL GR F Sbjct: 175 ISPEIATRSAHGLES-DVWSLGCMFYTLLIGRPPF 208 >3COM-A nrPDB Length = 314 Score = 91.3 bits (225), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 74/292 (25%), Positives = 135/292 (46%), Gaps = 45/292 (15%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E + L +G G+YGSV A +TG VA+K++ P +S + + +E+ +++ Sbjct: 29 EVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQV--PVESDL--QEIIKEISIMQQCDSP 84 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQK--LTDDHVQFLIYQILRGL 138 +V+ + + D+++V GA +++I++ + LT+D + ++ L+GL Sbjct: 85 HVVKYYGSYF------KNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGL 138 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG---YVATRWYRAPEIML 195 +Y+H IHRD+K N+ +N + K+ DFG+A D M + T ++ APE+ + Sbjct: 139 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV-I 197 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 + YN DIWS+G E+ G+ P I ++ I + P K Sbjct: 198 QEIGYNCVADIWSLGITAIEMAEGK---PPYADIHPMRAIFMIPTNPPPTFRK------- 247 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 P++ N D +++ LV ++R TA Q L H + Sbjct: 248 ----------PELWSDNF--------TDFVKQCLVKSPEQRATATQLLQHPF 281 >2WTK-C nrPDB Length = 305 Score = 91.3 bits (225), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 88/323 (27%), Positives = 141/323 (43%), Gaps = 52/323 (16%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII--HAKRTYRELRLLKHMKHENVIGLL 87 +G G+YG V D++T R AVK L + I +E++LL+ ++H+NVI L+ Sbjct: 13 LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLV 72 Query: 88 DVFTPARSLEEFNDVYLVTHLMGADLNNI---VKCQKLTDDHVQFLIYQILRGLKYIHSA 144 DV EE +Y+V + + V ++ Q++ GL+Y+HS Sbjct: 73 DVLYN----EEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQ 128 Query: 145 DIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEMTGYVATRWYRAPEIMLNWMH 199 I+H+D+KP NL + LKI G+A DD + ++ PEI Sbjct: 129 GIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDT 188 Query: 200 YNQ-TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY 258 ++ VDIWS G + + TG F G D+I +L Sbjct: 189 FSGFKVDIWSAGVTLYNITTGLYPFEG-DNIYKL-------------------------- 221 Query: 259 IQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEP 318 + K ++A PL+ DLL+ ML + KR + Q H++F + H P + P Sbjct: 222 ---FENIGKGSYAIPGDCGPPLS-DLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAP 277 Query: 319 VADPYDQSFESRDLLIDEWKSLT 341 V P S +++ D W+S+T Sbjct: 278 V--PIPPSPDTK----DRWRSMT 294 >2OU7-A nrPDB Length = 335 Score = 91.3 bits (225), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 81/297 (27%), Positives = 130/297 (43%), Gaps = 44/297 (14%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK-RTYRELRLLKHMKHENVIGLLD 88 +G G + D T A K + + H + + E+ + + + H++V+G Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 89 VFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQK-LTDDHVQFLIYQILRGLKYIHSADI 146 F E+ + V++V L L + K +K LT+ ++ + QI+ G +Y+H + Sbjct: 109 FF------EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 162 Query: 147 IHRDLKPSNLAVNEDCELKILDFGLARHTD---DEMTGYVATRWYRAPEIMLNWMHYNQT 203 IHRDLK NL +NED E+KI DFGLA + + T Y APE++ H + Sbjct: 163 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFE- 221 Query: 204 VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLT 263 VD+WS+GCIM LL G+ F +S Y++ Sbjct: 222 VDVWSIGCIMYTLLVGKPPFE--------------------------TSCLKETYLRI-- 253 Query: 264 QMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVA 320 K N ++ NP+A L++KML D R T + L +F + P P+ Sbjct: 254 ---KKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPIT 307 >5F9E-A nrPDB Length = 353 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 63/204 (30%), Positives = 103/204 (50%), Gaps = 12/204 (5%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH-AKRTYRELRLLK-HMKHENVIGLL 87 +G G++G V A KT A+K L + + + T E R+L +H + + Sbjct: 27 LGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMF 86 Query: 88 DVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHSADI 146 F +L +++ +L G DL +I C K F +I+ GL+++HS I Sbjct: 87 CTFQTKENL-----FFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGI 141 Query: 147 IHRDLKPSNLAVNEDCELKILDFGLARHT---DDEMTGYVATRWYRAPEIMLNWMHYNQT 203 ++RDLK N+ +++D +KI DFG+ + D + + T Y APEI+L YN + Sbjct: 142 VYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLG-QKYNHS 200 Query: 204 VDIWSVGCIMAELLTGRTLFPGTD 227 VD WS G ++ E+L G++ F G D Sbjct: 201 VDWWSFGVLLYEMLIGQSPFHGQD 224 >4CQG-A nrPDB Length = 331 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 76/298 (25%), Positives = 135/298 (45%), Gaps = 44/298 (14%) Query: 19 EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 E+ + Y+ +G+G + V A TG VA+K + + R E+ LK + Sbjct: 6 ELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGS-DLPRVKTEIDALKSL 64 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLV-THLMGADL-NNIVKCQKLTDDHVQFLIYQILR 136 +H+++ L V LE N +++V + G +L + I+ +L+++ + + QIL Sbjct: 65 RHQHICQLYHV------LETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILS 118 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR----HTDDEMTGYVATRWYRAPE 192 + Y+HS HRDLKP NL +E+ +LK++DFGL + D + + Y APE Sbjct: 119 AVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPE 178 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 ++ + D+WS+G ++ L+ G F + + K I+R Sbjct: 179 LIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMR--------------- 223 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 ++PK +P ++ LL++ML +D KRI+ L H + Q Sbjct: 224 --------GKYEVPKW--------LSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQ 265 >4J52-A nrPDB Length = 293 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 81/297 (27%), Positives = 130/297 (43%), Gaps = 44/297 (14%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK-RTYRELRLLKHMKHENVIGLLD 88 +G G + D T A K + + H + + E+ + + + H++V+G Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 89 VFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQK-LTDDHVQFLIYQILRGLKYIHSADI 146 F E+ + V++V L L + K +K LT+ ++ + QI+ G +Y+H + Sbjct: 82 FF------EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 135 Query: 147 IHRDLKPSNLAVNEDCELKILDFGLARHTD---DEMTGYVATRWYRAPEIMLNWMHYNQT 203 IHRDLK NL +NED E+KI DFGLA + + T Y APE++ H + Sbjct: 136 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFE- 194 Query: 204 VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLT 263 VD+WS+GCIM LL G+ F +S Y++ Sbjct: 195 VDVWSIGCIMYTLLVGKPPFE--------------------------TSCLKETYLRI-- 226 Query: 264 QMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVA 320 K N ++ NP+A L++KML D R T + L +F + P P+ Sbjct: 227 ---KKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPIT 280 >5IG1-A nrPDB Length = 344 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 63/208 (30%), Positives = 107/208 (51%), Gaps = 14/208 (6%) Query: 28 SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLL 87 S +G GA+ +V + +TG AVK ++ + RE+ + ++HE+++ + Sbjct: 23 SVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSM- 81 Query: 88 DVFTPARSLEEFNDVYLV-THLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHSAD 145 R+ + + YLV ++ G +L + IV + + ++QIL L++ HS + Sbjct: 82 -----RRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKN 136 Query: 146 IIHRDLKPSNL---AVNEDCELKILDFGLARHTDDEMT--GYVATRWYRAPEIMLNWMHY 200 IIHRDLKP NL + + + +KI DFGLA + T G+ T Y +PE+ + + Y Sbjct: 137 IIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEV-IRRVPY 195 Query: 201 NQTVDIWSVGCIMAELLTGRTLFPGTDH 228 + VD+W+ G I+ LL G F DH Sbjct: 196 DTAVDVWACGVILYILLVGYPPFWEEDH 223 >4YNZ-A nrPDB Length = 342 Score = 90.5 bits (223), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 83/293 (28%), Positives = 133/293 (45%), Gaps = 42/293 (14%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G G V T +VA+K ++R S + RE+ +LK ++H +V+ L DV Sbjct: 18 LGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDV 77 Query: 90 FTPARSLEEFNDVYLV-THLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHSADII 147 + + L YLV H+ G +L + +VK +LT + QI+ L + HS I Sbjct: 78 YENKKYL------YLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSIC 131 Query: 148 HRDLKPSNLAVNEDCELKILDFGLA--RHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVD 205 HRDLKP NL ++E ++I DFG+A + D + + Y PE++ + + D Sbjct: 132 HRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKAD 191 Query: 206 IWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQM 265 +WS G I+ LL G F D L+ +LL+K+ + + M Sbjct: 192 VWSCGVILFALLVGALPFDD----DNLR-----------QLLEKVK--------RGVFHM 228 Query: 266 PKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHA-YFAQYHDPDDE 317 P FI P LL M+ +D+ +R+T H Y ++P+ E Sbjct: 229 PH------FI--PPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPE 273 >2JAM-A nrPDB Length = 304 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 64/200 (32%), Positives = 98/200 (49%), Gaps = 15/200 (7%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +GSGA+ V TG A+K + + E+ +LK +KHEN++ L D+ Sbjct: 17 LGSGAFSEVFLVKQRLTGKLFALKCIKK--SPAFRDSSLENEIAVLKKIKHENIVTLEDI 74 Query: 90 FTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADII 147 + E YLV L+ G + I++ T+ +I Q+L +KY+H I+ Sbjct: 75 Y------ESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIV 128 Query: 148 HRDLKPSN---LAVNEDCELKILDFGLARHTDDE-MTGYVATRWYRAPEIMLNWMHYNQT 203 HRDLKP N L E+ ++ I DFGL++ + M+ T Y APE++ Y++ Sbjct: 129 HRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQ-KPYSKA 187 Query: 204 VDIWSVGCIMAELLTGRTLF 223 VD WS+G I LL G F Sbjct: 188 VDCWSIGVITYILLCGYPPF 207 >4D2V-A nrPDB Length = 356 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 80/312 (25%), Positives = 142/312 (45%), Gaps = 45/312 (14%) Query: 19 EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 E+ + Y+ +G+G + V A TG VA+K + + R E+ LK++ Sbjct: 26 ELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS-DLPRIKTEIEALKNL 84 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLV-THLMGADL-NNIVKCQKLTDDHVQFLIYQILR 136 +H+++ L V LE N +++V + G +L + I+ +L+++ + + QI+ Sbjct: 85 RHQHICQLYHV------LETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVS 138 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR----HTDDEMTGYVATRWYRAPE 192 + Y+HS HRDLKP NL +E +LK++DFGL + D + Y APE Sbjct: 139 AVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPE 198 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 ++ + D+WS+G ++ L+ G P D A L+ KI Sbjct: 199 LIQGKSYLGSEADVWSMGILLYVLMCG--FLPFDD-------------DTAAALVAKI-- 241 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ-Y 311 ++ +PK +P ++ LL++ML +D KRI+ L H + Q Y Sbjct: 242 ------MRGKYDVPKW--------LSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDY 287 Query: 312 HDPDDEPVADPY 323 + P + +P+ Sbjct: 288 NYPVEWQSKNPF 299 >5KKR-C nrPDB Length = 395 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 101/207 (48%), Gaps = 10/207 (4%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 ++ +S +G+G G V +GL +A K + + I + REL++L + Sbjct: 70 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSPYI 128 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK-CQKLTDDHVQFLIYQILRGLKYIH 142 +G F + + H+ G L+ ++K ++ + + + +++GL Y+ Sbjct: 129 VGFYGAFYSDGEIS-----ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 183 Query: 143 SA-DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT-GYVATRWYRAPEIMLNWMHY 200 I+HRD+KPSN+ VN E+K+ DFG++ D M +V TR Y +PE L HY Sbjct: 184 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPE-RLQGTHY 242 Query: 201 NQTVDIWSVGCIMAELLTGRTLFPGTD 227 + DIWS+G + E+ GR P D Sbjct: 243 SVQSDIWSMGLSLVEMAVGRYPIPPPD 269 >4OW8-A nrPDB Length = 283 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 66/210 (31%), Positives = 104/210 (49%), Gaps = 9/210 (4%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR-ELRLLKHMKHE 81 RY+ + +G G V A D + G RVAVK L F S +R E R + H Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 71 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVK-CQKLTDDHVQFLIYQILRGLK 139 + + D + ++ E YLV L+ G LN+++K +L+ H ++ Q R L+ Sbjct: 72 GIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 130 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYV-ATRWYRAPEIML 195 H+A ++HRD+KP N+ + ++KI DFG+A+ D TG V T Y APE L Sbjct: 131 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 190 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPG 225 + D++S+G + E ++G+ F G Sbjct: 191 GH-DASPASDVYSLGVVGYEAVSGKRPFAG 219 >3KN6-A nrPDB Length = 325 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 73/284 (25%), Positives = 134/284 (47%), Gaps = 53/284 (18%) Query: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-HENVIGLL 87 P+G G++ K+ AVK +S+ ++ T +E+ LK + H N++ L Sbjct: 18 PLGEGSFSICRKCVHKKSNQAFAVKIISKRMEA-----NTQKEITALKLCEGHPNIVKLH 72 Query: 88 DVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGLKYIHSADI 146 +VF ++ + ++ L G +L +K +K ++ +++ +++ + ++H + Sbjct: 73 EVFH-----DQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV 127 Query: 147 IHRDLKPSNLAV---NEDCELKILDFGLARHT---DDEMTGYVATRWYRAPEIMLNWMHY 200 +HRDLKP NL N++ E+KI+DFG AR + + T Y APE +LN Y Sbjct: 128 VHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE-LLNQNGY 186 Query: 201 NQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS-------SE 253 +++ D+WS+G I+ +L+G+ F D L T E++KKI E Sbjct: 187 DESCDLWSLGVILYTMLSGQVPFQSHDR--------SLTCTSAVEIMKKIKKGDFSFEGE 238 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI 297 + +N Q A DL++ +L +D +KR+ Sbjct: 239 AWKNVSQE-------------------AKDLIQGLLTVDPNKRL 263 >4L42-A nrPDB Length = 346 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 67/227 (29%), Positives = 111/227 (48%), Gaps = 17/227 (7%) Query: 21 PERYQNLSPVGSGAYGSVC---AAFDTKTGLRVAVKKLSRPF--QSIIHAKRTYRELRLL 75 PE ++ L +G G YG V TG A+K L + ++ T E +L Sbjct: 17 PECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL 76 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLV-THLMGADLNNIVKCQKL-TDDHVQFLIYQ 133 + +KH ++ L+ F L YL+ +L G +L ++ + + +D F + + Sbjct: 77 EEVKHPFIVDLIYAFQTGGKL------YLILEYLSGGELFMQLEREGIFMEDTACFYLAE 130 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT---GYVATRWYRA 190 I L ++H II+RDLKP N+ +N +K+ DFGL + + + T + T Y A Sbjct: 131 ISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMA 190 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 PEI++ H N+ VD WS+G +M ++LTG F G + + IL+ Sbjct: 191 PEILMRSGH-NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK 236 >3EQC-A nrPDB Length = 360 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 101/207 (48%), Gaps = 10/207 (4%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 ++ +S +G+G G V +GL +A K + + I + REL++L + Sbjct: 35 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSPYI 93 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK-CQKLTDDHVQFLIYQILRGLKYIH 142 +G F + + H+ G L+ ++K ++ + + + +++GL Y+ Sbjct: 94 VGFYGAFYSDGEIS-----ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 148 Query: 143 SA-DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT-GYVATRWYRAPEIMLNWMHY 200 I+HRD+KPSN+ VN E+K+ DFG++ D M +V TR Y +PE L HY Sbjct: 149 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPE-RLQGTHY 207 Query: 201 NQTVDIWSVGCIMAELLTGRTLFPGTD 227 + DIWS+G + E+ GR P D Sbjct: 208 SVQSDIWSMGLSLVEMAVGRYPIPPPD 234 >6B2Q-A nrPDB Length = 317 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 66/210 (31%), Positives = 104/210 (49%), Gaps = 9/210 (4%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR-ELRLLKHMKHE 81 RY+ + +G G V A D + G RVAVK L F S +R E R + H Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 92 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVK-CQKLTDDHVQFLIYQILRGLK 139 + + D + ++ E YLV L+ G LN+++K +L+ H ++ Q R L+ Sbjct: 93 GIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 151 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYV-ATRWYRAPEIML 195 H+A ++HRD+KP N+ + ++KI DFG+A+ D TG V T Y APE L Sbjct: 152 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 211 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPG 225 + D++S+G + E ++G+ F G Sbjct: 212 GH-DASPASDVYSLGVVGYEAVSGKRPFAG 240 >4D28-A nrPDB Length = 446 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 62/214 (28%), Positives = 105/214 (49%), Gaps = 18/214 (8%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTY----RELRLLKHM 78 +Y+ +G G + V A +T TG VA+K +++ S I R RE+ ++K + Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAK---STILKNRMVDQIKREISIMKIV 66 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILR 136 +H N++ L +V L + +Y+V + G + IV +L +D + Q++ Sbjct: 67 RHPNIVRLYEV------LASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVD 120 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA---RHTDDEMTGYVATRWYRAPEI 193 + + HS + HRDLKP NL ++ + LK+ DFGL+ + + + T Y APE+ Sbjct: 121 AVAHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEV 180 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTD 227 + + DIWS G I+ +L G F TD Sbjct: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETD 214 >3DLS-A nrPDB Length = 335 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 106/210 (50%), Gaps = 17/210 (8%) Query: 19 EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH--------AKRTYR 70 E ++Y +SP+GSGA+G V A D + V VK + + + ++ + Sbjct: 21 EYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKK--EKVLEDCWIEDPKLGKVTL 78 Query: 71 ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQKLTDDHVQF 129 E+ +L ++H N+I +LD+F + F + + H G DL + + +L + + Sbjct: 79 EIAILSRVEHANIIKVLDIFEN----QGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASY 134 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY--VATRW 187 + Q++ + Y+ DIIHRD+K N+ + ED +K++DFG A + + Y T Sbjct: 135 IFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIE 194 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 Y APE+++ + +++WS+G + L+ Sbjct: 195 YCAPEVLMGNPYRGPELEMWSLGVTLYTLV 224 >4X3F-A nrPDB Length = 337 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 66/210 (31%), Positives = 104/210 (49%), Gaps = 9/210 (4%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR-ELRLLKHMKHE 81 RY+ + +G G V A D + G RVAVK L F S +R E R + H Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 72 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVK-CQKLTDDHVQFLIYQILRGLK 139 + + D + ++ E YLV L+ G LN+++K +L+ H ++ Q R L+ Sbjct: 73 GIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 131 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYV-ATRWYRAPEIML 195 H+A ++HRD+KP N+ + ++KI DFG+A+ D TG V T Y APE L Sbjct: 132 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 191 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPG 225 + D++S+G + E ++G+ F G Sbjct: 192 GH-DASPASDVYSLGVVGYEAVSGKRPFAG 220 >1KOA-A nrPDB Length = 491 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 86/329 (26%), Positives = 141/329 (42%), Gaps = 49/329 (14%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G+GA+G V + TG A K + P +S R +E++ + ++H ++ L D Sbjct: 59 LGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVR--KEIQTMSVLRHPTLVNLHDA 116 Query: 90 FTPARSLEEFNDVYLVTHLM-GADLNNIV--KCQKLTDDHVQFLIYQILRGLKYIHSADI 146 F E+ N++ ++ M G +L V + K+++D + Q+ +GL ++H + Sbjct: 117 F------EDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHENNY 170 Query: 147 IHRDLKPSNL--AVNEDCELKILDFGLARHTDDEMTGYV--ATRWYRAPEIMLNWMHYNQ 202 +H DLKP N+ ELK++DFGL H D + + V T + APE+ Sbjct: 171 VHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEG-KPVGY 229 Query: 203 TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSL 262 D+WSVG + LL+G + F G + E+ RN Sbjct: 230 YTDMWSVGVLSYILLSGLSPFGGEN-----------------------DDETLRNVKSCD 266 Query: 263 TQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADP 322 M + F G + D + K+L+ D + R+T QAL H + P + P D Sbjct: 267 WNMDD----SAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT----PGNAPGRD- 317 Query: 323 YDQSFESRDLLIDEWKSLTYDEVISFVPP 351 Q SR I + YD +PP Sbjct: 318 -SQIPSSRYTKIRDSIKTKYDAWPEPLPP 345 >4AN9-A nrPDB Length = 301 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 58/200 (29%), Positives = 100/200 (50%), Gaps = 10/200 (5%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 ++ +S +G+G G V +GL +A K + + I + REL++L + Sbjct: 11 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSPYI 69 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK-CQKLTDDHVQFLIYQILRGLKYIH 142 +G F + + H+ G L+ ++K ++ + + + +++GL Y+ Sbjct: 70 VGFYGAFYSDGEIS-----ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 124 Query: 143 SA-DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG-YVATRWYRAPEIMLNWMHY 200 I+HRD+KPSN+ VN E+K+ DFG++ DEM +V TR Y +PE L HY Sbjct: 125 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPE-RLQGTHY 183 Query: 201 NQTVDIWSVGCIMAELLTGR 220 + DIWS+G + E+ GR Sbjct: 184 SVQSDIWSMGLSLVEMAVGR 203 >3UTO-A nrPDB Length = 573 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 86/329 (26%), Positives = 141/329 (42%), Gaps = 49/329 (14%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G+GA+G V + TG A K + P +S R +E++ + ++H ++ L D Sbjct: 165 LGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVR--KEIQTMSVLRHPTLVNLHDA 222 Query: 90 FTPARSLEEFNDVYLVTHLM-GADLNNIV--KCQKLTDDHVQFLIYQILRGLKYIHSADI 146 F E+ N++ ++ M G +L V + K+++D + Q+ +GL ++H + Sbjct: 223 F------EDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHENNY 276 Query: 147 IHRDLKPSNL--AVNEDCELKILDFGLARHTDDEMTGYV--ATRWYRAPEIMLNWMHYNQ 202 +H DLKP N+ ELK++DFGL H D + + V T + APE+ Sbjct: 277 VHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEG-KPVGY 335 Query: 203 TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSL 262 D+WSVG + LL+G + F G + E+ RN Sbjct: 336 YTDMWSVGVLSYILLSGLSPFGGEN-----------------------DDETLRNVKSCD 372 Query: 263 TQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADP 322 M + F G + D + K+L+ D + R+T QAL H + P + P D Sbjct: 373 WNMDD----SAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT----PGNAPGRD- 423 Query: 323 YDQSFESRDLLIDEWKSLTYDEVISFVPP 351 Q SR I + YD +PP Sbjct: 424 -SQIPSSRYTKIRDSIKTKYDAWPEPLPP 451 >6CCF-A nrPDB Length = 290 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 60/232 (25%), Positives = 109/232 (46%), Gaps = 36/232 (15%) Query: 23 RYQNLSPVGSGAYGSVCAA------------------------FDTKTGLRVAVKKLSRP 58 +Y+ S +G GAYG V A F + R + P Sbjct: 6 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGP 65 Query: 59 FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFT-PARSLEEFNDVYLVTHLMGADLNNIV 117 + ++ +R Y+E+ +LK + H NV+ L++V PA +++YLV L+ V Sbjct: 66 AKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAE-----DNLYLVFDLLRKGPVMEV 120 Query: 118 KCQK-LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH-- 174 C K +++ + + ++ GL+Y+H I+HRD+KPSNL + +D +KI DFG++ Sbjct: 121 PCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 180 Query: 175 -TDDEMTGYVATRWYRAPEIMLNWMH--YNQTVDIWSVGCIMAELLTGRTLF 223 D +++ T + APE + + + +D+W+ G + + G+ F Sbjct: 181 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF 232 >5N23-A nrPDB Length = 352 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 59/219 (26%), Positives = 112/219 (51%), Gaps = 22/219 (10%) Query: 18 WEVP-------ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR--- 67 WE P ++++ + +G+G++G V +TG A+K L + Q ++ K+ Sbjct: 31 WESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDK--QKVVKLKQIEH 88 Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDD 125 T E R+ + + ++ L S ++ +++Y+V G +++ + + ++ Sbjct: 89 TLNEKRIQQAVNFPFLVKL------EFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEP 142 Query: 126 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT-GYVA 184 H +F QI+ +Y+HS D+I+RDLKP NL +++ +K+ DFG A+ Sbjct: 143 HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWTLCG 202 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLF 223 T Y APEI+L+ YN+ VD W++G ++ E+ G F Sbjct: 203 TPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPF 240 >2Y7J-A nrPDB Length = 365 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 79/308 (25%), Positives = 140/308 (45%), Gaps = 52/308 (16%) Query: 22 ERYQNLSP---VGSGAYGSVCAAFDTKTGLRVAVKKLS------RPFQSIIHAKRTYREL 72 E YQ P +G G V TG AVK + P Q + T RE Sbjct: 91 EFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRET 150 Query: 73 RLLKHMK-HENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQF 129 +L+ + H ++I L+D S E + ++LV LM G + + + L++ + Sbjct: 151 HILRQVAGHPHIITLID------SYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRS 204 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD--DEMTGYVATRW 187 ++ +L + ++H+ +I+HRDLKP N+ ++++ ++++ DFG + H + +++ T Sbjct: 205 IMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPG 264 Query: 188 YRAPEIMLNWMH-----YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 242 Y APEI+ M Y + VD+W+ G I+ LL G F I L++I+ Sbjct: 265 YLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIM------ 318 Query: 243 GAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQA 302 E + SS + ++ DL+ ++L +D + R+TA QA Sbjct: 319 --EGQYQFSSPEWDDRSSTVK-------------------DLISRLLQVDPEARLTAEQA 357 Query: 303 LAHAYFAQ 310 L H +F + Sbjct: 358 LQHPFFER 365 >4CFF-A nrPDB Length = 571 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 64/200 (32%), Positives = 100/200 (50%), Gaps = 13/200 (6%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 +G G +G V TG +VAVK L+R +S+ + RE++ LK +H ++I L Sbjct: 41 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 100 Query: 89 VF-TPARSLEEFNDVYLVT-HLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHSAD 145 V TP D ++V ++ G +L + I K ++ + + L QIL + Y H Sbjct: 101 VISTP-------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 153 Query: 146 IIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWMHYNQT 203 ++HRDLKP N+ ++ KI DFGL+ D + + Y APE++ ++ Sbjct: 154 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPE 213 Query: 204 VDIWSVGCIMAELLTGRTLF 223 VDIWS G I+ LL G F Sbjct: 214 VDIWSCGVILYALLCGTLPF 233 >5YV8-A nrPDB Length = 298 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 58/224 (25%), Positives = 108/224 (48%), Gaps = 34/224 (15%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRP------------------------FQSIIHA 65 +G G+YG V A++ A+K LS+ Q Sbjct: 21 IGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPI 80 Query: 66 KRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQKLTD 124 ++ Y+E+ +LK + H NV+ L++V + +Y+V L+ + + + L++ Sbjct: 81 EQVYQEIAILKKLDHPNVVKLVEVLDDPNE----DHLYMVFELVNQGPVMEVPTLKPLSE 136 Query: 125 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA---RHTDDEMTG 181 D +F +++G++Y+H IIHRD+KPSNL V ED +KI DFG++ + +D ++ Sbjct: 137 DQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSN 196 Query: 182 YVATRWYRAPEIM--LNWMHYNQTVDIWSVGCIMAELLTGRTLF 223 V T + APE + + + +D+W++G + + G+ F Sbjct: 197 TVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF 240 >3ORZ-A nrPDB Length = 316 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 75/280 (26%), Positives = 121/280 (43%), Gaps = 46/280 (16%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRT---YRELRLLKHMKHENVIGL 86 +G G++ +V A + T A+K L + + II + RE ++ + H + L Sbjct: 45 LGEGSFSTVVLARELATSREYAIKILEK--RHIIKENKVPYVTRERDVMSRLDHPFFVKL 102 Query: 87 LDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADI 146 F L F Y G L I K + +F +I+ L+Y+H I Sbjct: 103 YFCFQDDEKLY-FGLSYAKN---GELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGI 158 Query: 147 IHRDLKPSNLAVNEDCELKILDFGLARHTDDE-----MTGYVATRWYRAPEIMLNWMHYN 201 IHRDLKP N+ +NED ++I DFG A+ E +V T Y +PE +L Sbjct: 159 IHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPE-LLTEKSAC 217 Query: 202 QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQS 261 ++ D+W++GCI+ +L+ G F + + I++L Sbjct: 218 KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL----------------------- 254 Query: 262 LTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQ 301 + +F F P A DL+EK+LVLD+ KR+ + Sbjct: 255 -----EYDFPEKFF---PKARDLVEKLLVLDATKRLGCEE 286 >2XNP-A nrPDB Length = 279 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 67/212 (31%), Positives = 112/212 (52%), Gaps = 25/212 (11%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTY--RELRLLKHMK 79 E Y+ L +G+G+YG C K+ ++ V K + S+ A++ E+ LL+ +K Sbjct: 6 EDYEVLYTIGTGSYGR-CQKIRRKSDGKILVWK-ELDYGSMTEAEKQMLVSEVNLLRELK 63 Query: 80 HENVIGLLDVFTPARSLEEFND-VYLVT-HLMGADLNNIV-----KCQKLTDDHVQFLIY 132 H N++ D R ++ N +Y+V + G DL +++ + Q L ++ V ++ Sbjct: 64 HPNIVRYYD-----RIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMT 118 Query: 133 QILRGLKYIHSAD-----IIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTGYVA 184 Q+ LK H ++HRDLKP+N+ ++ +K+ DFGLAR H +V Sbjct: 119 QLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVG 178 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAEL 216 T +Y +PE M N M YN+ DIWS+GC++ EL Sbjct: 179 TPYYMSPEQM-NRMSYNEKSDIWSLGCLLYEL 209 >4RLP-A nrPDB Length = 288 Score = 88.2 bits (217), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 67/227 (29%), Positives = 111/227 (48%), Gaps = 17/227 (7%) Query: 21 PERYQNLSPVGSGAYGSVC---AAFDTKTGLRVAVKKLSRPF--QSIIHAKRTYRELRLL 75 PE ++ L +G G YG V TG A+K L + ++ T E +L Sbjct: 4 PECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL 63 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLV-THLMGADLNNIVKCQKL-TDDHVQFLIYQ 133 + +KH ++ L+ F L YL+ +L G +L ++ + + +D F + + Sbjct: 64 EEVKHPFIVDLIYAFQTGGKL------YLILEYLSGGELFMQLEREGIFMEDTACFYLAE 117 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT---GYVATRWYRA 190 I L ++H II+RDLKP N+ +N +K+ DFGL + + + T + T Y A Sbjct: 118 ISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMA 177 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 PEI++ H N+ VD WS+G +M ++LTG F G + + IL+ Sbjct: 178 PEILMRSGH-NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK 223 >6BDL-A nrPDB Length = 347 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 72/218 (33%), Positives = 105/218 (48%), Gaps = 14/218 (6%) Query: 56 SRPFQSIIHAKRTYRELRLLKHMKHENVI--GLLDVFTPARSLEEFNDVYLVTHLM---- 109 S+ F I KR + R +H++ E I G F R F D + LM Sbjct: 60 SKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFI-VRLYRTFKDSKYLYMLMEACL 118 Query: 110 GADLNNIVKCQ-KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILD 168 G +L I++ + D +F ++ Y+HS II+RDLKP NL ++ K++D Sbjct: 119 GGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVD 178 Query: 169 FGLARHT--DDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGT 226 FG A+ + + T Y APEI+LN H + + D WS+G +M ELLTG F G Sbjct: 179 FGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGH-DISADYWSLGILMYELLTGSPPFSGP 237 Query: 227 DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQ 264 D + +ILR G E KKI+ +A N I+ L + Sbjct: 238 DPMKTYNIILR--GIDMIEFPKKIAKNAA-NLIKKLCR 272 >4UYA-A nrPDB Length = 340 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 73/223 (32%), Positives = 110/223 (49%), Gaps = 24/223 (10%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQ-SIIHAKRTYRELRLLKHMK 79 ER + +G+G +G V A T G VAVK + P Q + A+ RE RL ++ Sbjct: 26 ERLELKELIGAGGFGQVYRA--TWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLR 83 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLK 139 H N+I L V L++ + ++ G LN + +++ + QI RG+ Sbjct: 84 HPNIIELRGV-----CLQQPHLCLVLEFARGGALNRALAGRRIPPHVLVNWAVQIARGML 138 Query: 140 YIHS---ADIIHRDLKPSNLAVNEDCE--------LKILDFGLAR--HTDDEMTGYVATR 186 Y+H I+HRDLK SN+ + E E LKI DFGLAR H +M A Sbjct: 139 YLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAYA 198 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI 229 W APE++ + + +++ DIWS G ++ ELLTG + G D + Sbjct: 199 WM-APEVIKSSL-FSKGSDIWSYGVLLWELLTGEVPYRGIDGL 239 >5EZV-A nrPDB Length = 560 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 62/199 (31%), Positives = 99/199 (49%), Gaps = 11/199 (5%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 +G G +G V TG +VAVK L+R +S+ + RE++ LK +H ++I L Sbjct: 36 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 95 Query: 89 VFTPARSLEEFNDVYLVT-HLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHSADI 146 V + D ++V ++ G +L + I K ++ + + L QIL + Y H + Sbjct: 96 VISTP------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 149 Query: 147 IHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWMHYNQTV 204 +HRDLKP N+ ++ KI DFGL+ D + + Y APE++ ++ V Sbjct: 150 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEV 209 Query: 205 DIWSVGCIMAELLTGRTLF 223 DIWS G I+ LL G F Sbjct: 210 DIWSCGVILYALLCGTLPF 228 >1U5R-A nrPDB Length = 348 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 69/250 (27%), Positives = 125/250 (50%), Gaps = 16/250 (6%) Query: 21 PER-YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSIIHAKRTYRELRLLKHM 78 PE+ + +L +G G++G+V A D + VA+KK+S QS + +E+R L+ + Sbjct: 52 PEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL 111 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA--DLNNIVKCQKLTDDHVQFLIYQILR 136 +H N I + L E ++ + +G+ DL + K + L + + + + L+ Sbjct: 112 RHPNTIQYRGCY-----LREHTAWLVMEYCLGSASDLLEVHK-KPLQEVEIAAVTHGALQ 165 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIML- 195 GL Y+HS ++IHRD+K N+ ++E +K+ DFG A +V T ++ APE++L Sbjct: 166 GLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS-IMAPANSFVGTPYWMAPEVILA 224 Query: 196 -NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 + Y+ VD+WS+G EL + P +++ + + + L SE Sbjct: 225 MDEGQYDGKVDVWSLGITCIELAERK---PPLFNMNAMSALYHIAQNESPALQSGHWSEY 281 Query: 255 ARNYIQSLTQ 264 RN++ S Q Sbjct: 282 FRNFVDSCLQ 291 >6FDY-U nrPDB Length = 276 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 78/292 (26%), Positives = 135/292 (46%), Gaps = 42/292 (14%) Query: 30 VGSGAYGSVCAAFDTK-TGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 +GSG Y +V A+ K T VA+K +++ + + E+ +LK ++H +++ L D Sbjct: 19 LGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKD 78 Query: 89 VFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHV-QFLIYQILRGLKYIHSADI 146 + +++YL+ G DL+ + +++ + V + + Q+ L+++H +I Sbjct: 79 FQWDS------DNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNI 132 Query: 147 IHRDLKPSNLAVN--EDCELKILDFGLARHTD--DEMTGYVATRWYRAPEIMLNWMHYNQ 202 H DLKP N+ ++ E LK+ DFG A+H DE + Y APE M+ Y+ Sbjct: 133 SHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPE-MVCQRQYDA 191 Query: 203 TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSL 262 VD+WS+G I+ E L G+ F +EL +KI S N + L Sbjct: 192 RVDLWSMGVILYEALFGQPPFASRSF---------------SELEEKIRS----NRVIEL 232 Query: 263 TQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 314 P ++ DLL+++L D +RI+ AH + H P Sbjct: 233 PLRPLLSRD---------CRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMP 275 >2GCD-A nrPDB Length = 309 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 69/250 (27%), Positives = 125/250 (50%), Gaps = 16/250 (6%) Query: 21 PER-YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSIIHAKRTYRELRLLKHM 78 PE+ + +L +G G++G+V A D + VA+KK+S QS + +E+R L+ + Sbjct: 13 PEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL 72 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA--DLNNIVKCQKLTDDHVQFLIYQILR 136 +H N I + L E ++ + +G+ DL + K + L + + + + L+ Sbjct: 73 RHPNTIQYRGCY-----LREHTAWLVMEYCLGSASDLLEVHK-KPLQEVEIAAVTHGALQ 126 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIML- 195 GL Y+HS ++IHRD+K N+ ++E +K+ DFG A +V T ++ APE++L Sbjct: 127 GLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS-IMAPANSFVGTPYWMAPEVILA 185 Query: 196 -NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 + Y+ VD+WS+G EL + P +++ + + + L SE Sbjct: 186 MDEGQYDGKVDVWSLGITCIELAERK---PPLFNMNAMSALYHIAQNESPALQSGHWSEY 242 Query: 255 ARNYIQSLTQ 264 RN++ S Q Sbjct: 243 FRNFVDSCLQ 252 >5KCV-A nrPDB Length = 460 Score = 87.4 bits (215), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 64/222 (28%), Positives = 112/222 (50%), Gaps = 18/222 (8%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK----RTYRELRLLKHMK 79 ++ L +G G +G V + TG A+K L + +I AK T E R+L++ + Sbjct: 164 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKK---EVIVAKDEVAHTLTENRVLQNSR 220 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLN-NIVKCQKLTDDHVQFLIYQILRGL 138 H + L F L +++ + G +L ++ + + ++D +F +I+ L Sbjct: 221 HPFLTALKYSFQTHDRL-----CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 275 Query: 139 KYIHS-ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVATRWYRAPEIM 194 Y+HS ++++RDLK NL +++D +KI DFGL + + M + T Y APE++ Sbjct: 276 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 335 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 + Y + VD W +G +M E++ GR F DH +LIL Sbjct: 336 ED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL 376 >1KOB-A nrPDB Length = 387 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 66/247 (26%), Positives = 122/247 (49%), Gaps = 15/247 (6%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 Y L +GSGA+G V + TG K ++ P+ + E+ ++ + H + Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYP--LDKYTVKNEISIMNQLHHPKL 110 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ--KLTDDHVQFLIYQILRGLKYI 141 I L D F +++ V ++ L G +L + + + K+++ V + Q GLK++ Sbjct: 111 INLHDAFE-----DKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHM 165 Query: 142 HSADIIHRDLKPSNL--AVNEDCELKILDFGLAR--HTDDEMTGYVATRWYRAPEIMLNW 197 H I+H D+KP N+ + +KI+DFGLA + D+ + AT + APEI ++ Sbjct: 166 HEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEI-VDR 224 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 D+W++G + LL+G + F G D ++ L+ + R + +S E A++ Sbjct: 225 EPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSSVSPE-AKD 283 Query: 258 YIQSLTQ 264 +I++L Q Sbjct: 284 FIKNLLQ 290 >3MV5-A nrPDB Length = 342 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 64/222 (28%), Positives = 112/222 (50%), Gaps = 18/222 (8%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK----RTYRELRLLKHMK 79 ++ L +G G +G V + TG A+K L + +I AK T E R+L++ + Sbjct: 12 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKK---EVIVAKDEVAHTLTENRVLQNSR 68 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLN-NIVKCQKLTDDHVQFLIYQILRGL 138 H + L F L +++ + G +L ++ + + ++D +F +I+ L Sbjct: 69 HPFLTALKYSFQTHDRL-----CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 123 Query: 139 KYIHS-ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVATRWYRAPEIM 194 Y+HS ++++RDLK NL +++D +KI DFGL + + M + T Y APE++ Sbjct: 124 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 183 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 + Y + VD W +G +M E++ GR F DH +LIL Sbjct: 184 ED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL 224 >4CSV-A nrPDB Length = 275 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 67/234 (28%), Positives = 117/234 (50%), Gaps = 23/234 (9%) Query: 18 WEVPERYQNLS-PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 WE+P L +GSG +G V + VAVK L S+ + +E +++K Sbjct: 6 WEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSV---EEFLQEAQIMK 62 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFL--IY 132 +KH N++ L V T +Y++T M G+ L+ + C+ T + L Sbjct: 63 KLKHPNLVQLYGVCTKEPP------IYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAA 116 Query: 133 QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH-TDDEMTGYVATRW---Y 188 Q+ G+ Y+ S + IHRDL N V E+ +K+ DFGLAR +DE T ++ + Sbjct: 117 QVASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKW 176 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFP---GTDHIDQLKLILRL 238 APE +++ ++ D+W+ G ++ E+ T G+ +P G++ I+Q++ R+ Sbjct: 177 TAPE-AISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRM 229 >4LG4-A nrPDB Length = 299 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 73/293 (24%), Positives = 137/293 (46%), Gaps = 45/293 (15%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E + L +G G+YGSV A ++G VA+K++ P +S + + +E+ +++ Sbjct: 11 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV--PVESDL--QEIIKEISIMQQCDSP 66 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQK--LTDDHVQFLIYQILRGL 138 V+ S + D+++V GA +++I++ + L +D + ++ L+GL Sbjct: 67 YVVKYYG------SYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGL 120 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG---YVATRWYRAPEIML 195 +Y+H IHR++K N+ +N + K+ DFG+A D M + T ++ APE+ + Sbjct: 121 EYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV-I 179 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 + YN DIWS+G E+ G+ P I ++ I + P K Sbjct: 180 QEIGYNCVADIWSLGITSIEMAEGK---PPYADIHPMRAIFMIPTNPPPTFRK------- 229 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 P++ +++ F D ++K LV + ++R TA Q L H + Sbjct: 230 ----------PEL-WSDDF-------TDFVKKCLVKNPEQRATATQLLQHPFI 264 >6AO5-A nrPDB Length = 362 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 72/293 (24%), Positives = 137/293 (46%), Gaps = 45/293 (15%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E + L +G G+YGSV A ++G VA+K++ P +S + + +E+ +++ Sbjct: 10 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV--PVESDL--QEIIKEISIMQQCDSP 65 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQK--LTDDHVQFLIYQILRGL 138 V+ + + D+++V GA +++I++ + L +D + ++ L+GL Sbjct: 66 YVVKYYGSYF------KNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGL 119 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG---YVATRWYRAPEIML 195 +Y+H IHR++K N+ +N + K+ DFG+A D M + T ++ APE+ + Sbjct: 120 EYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV-I 178 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 + YN DIWS+G E+ G+ P I ++ I + P K Sbjct: 179 QEIGYNCVADIWSLGITSIEMAEGK---PPYADIHPMRAIFMIPTNPPPTFRK------- 228 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 P++ +++ F D ++K LV + ++R TA Q L H + Sbjct: 229 ----------PEL-WSDDF-------TDFVKKCLVKNPEQRATATQLLQHPFI 263 >5SYS-A nrPDB Length = 286 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 66/243 (27%), Positives = 115/243 (47%), Gaps = 21/243 (8%) Query: 11 QELNKTIWEVPERYQNLS-PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTY 69 Q L K WE+P L +G G +G C RVA+K L + + Sbjct: 6 QGLAKDAWEIPRESLRLEVKLGQGCFGE-CWMGTWNGTTRVAIKTLK---PGTMSPEAFL 61 Query: 70 RELRLLKHMKHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 +E +++K ++HE ++ L V + P + E+ + + ++ ++ +L D Sbjct: 62 QEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVD--- 118 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-EMTGYVATR 186 + QI G+ Y+ + +HRDL+ +N+ V E+ K+ DFGLAR +D E T + Sbjct: 119 --MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK 176 Query: 187 W---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT---DHIDQLKLILRLV 239 + + APE L + + D+WS G ++ EL T GR +PG + +DQ++ R+ Sbjct: 177 FPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP 235 Query: 240 GTP 242 P Sbjct: 236 CPP 238 >2YZA-A nrPDB Length = 276 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 62/199 (31%), Positives = 99/199 (49%), Gaps = 11/199 (5%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 +G G +G V TG +VAVK L+R +S+ + RE++ LK +H ++I L Sbjct: 19 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 78 Query: 89 VFTPARSLEEFNDVYLVT-HLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHSADI 146 V + D ++V ++ G +L + I K ++ + + L QIL + Y H + Sbjct: 79 VISTP------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 132 Query: 147 IHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWMHYNQTV 204 +HRDLKP N+ ++ KI DFGL+ D + + Y APE++ ++ V Sbjct: 133 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYAGPEV 192 Query: 205 DIWSVGCIMAELLTGRTLF 223 DIWS G I+ LL G F Sbjct: 193 DIWSCGVILYALLCGTLPF 211 >2HW6-A nrPDB Length = 307 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 77/302 (25%), Positives = 137/302 (45%), Gaps = 48/302 (15%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-HENVIGLLD 88 +G GAY V A + G AVK + + Q+ R +RE+ L + ++N++ L++ Sbjct: 21 LGEGAYAKVQGAVSLQNGKEYAVKIIEK--QAGHSRSRVFREVETLYQCQGNKNILELIE 78 Query: 89 VFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADI 146 F E+ YLV + G+ L +I K + + ++ + L ++H+ I Sbjct: 79 FF------EDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGI 132 Query: 147 IHRDLKPSNLAVNEDCE-------LKILDFGLARH----------TDDEMTGYVATRWYR 189 HRDLKP N+ CE +KI DF L T E+T + Y Sbjct: 133 AHRDLKPENIL----CESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYM 188 Query: 190 APEIMLNW----MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 APE++ + Y++ D+WS+G ++ +L+G F G D G E Sbjct: 189 APEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD--------CGWDRGE 240 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAH 305 + + ++ + + + P ++A++ + A DL+ K+LV D+ +R++AAQ L H Sbjct: 241 VCRVCQNKLFESIQEGKYEFPDKDWAHI----SSEAKDLISKLLVRDAKQRLSAAQVLQH 296 Query: 306 AY 307 + Sbjct: 297 PW 298 >1PHK-A nrPDB Length = 298 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 83/308 (26%), Positives = 136/308 (44%), Gaps = 53/308 (17%) Query: 24 YQNLSP---VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR-------TYRELR 73 Y+N P +G G V T AVK + A+ T +E+ Sbjct: 16 YENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVD 75 Query: 74 LLKHMK-HENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFL 130 +L+ + H N+I L D + E +LV LM G + + + L++ + + Sbjct: 76 ILRKVSGHPNIIQLKDTY------ETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKI 129 Query: 131 IYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD--DEMTGYVATRWY 188 + +L + +H +I+HRDLKP N+ +++D +K+ DFG + D +++ T Y Sbjct: 130 MRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSY 189 Query: 189 RAPEIMLNWMH-----YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPG 243 APEI+ M+ Y + VD+WS G IM LL G P H Q+ L+LR++ + Sbjct: 190 LAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGS---PPFWHRKQM-LMLRMIMSGN 245 Query: 244 AELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQAL 303 + S +Y ++ DL+ + LV+ KR TA +AL Sbjct: 246 YQF----GSPEWDDYSDTVK-------------------DLVSRFLVVQPQKRYTAEEAL 282 Query: 304 AHAYFAQY 311 AH +F QY Sbjct: 283 AHPFFQQY 290 >4XEY-B nrPDB Length = 408 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 67/235 (28%), Positives = 112/235 (47%), Gaps = 20/235 (8%) Query: 3 QERPTFYRQELNKTIWEVPERYQNLS-PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 + +PT Y N WE+ + +G G YG V K L VAVK L + Sbjct: 105 RNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---ED 161 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKC 119 + + +E ++K +KH N++ LL V T Y++T M G L+ + +C Sbjct: 162 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPF------YIITEFMTYGNLLDYLREC 215 Query: 120 QKLTDDHVQ--FLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-HTD 176 + + V ++ QI ++Y+ + IHRDL N V E+ +K+ DFGL+R T Sbjct: 216 NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTG 275 Query: 177 DEMTGYVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTD 227 D T + ++ + APE L + ++ D+W+ G ++ E+ T G + +PG D Sbjct: 276 DTYTAHAGAKFPIKWTAPE-SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID 329 >2H8H-A nrPDB Length = 535 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 68/243 (27%), Positives = 117/243 (48%), Gaps = 21/243 (8%) Query: 11 QELNKTIWEVPERYQNLS-PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTY 69 Q L K WE+P L +G G +G V T RVA+K L +P + + Sbjct: 255 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTL-KP--GTMSPEAFL 310 Query: 70 RELRLLKHMKHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 +E +++K ++HE ++ L V + P + E+ + + + ++ +L D Sbjct: 311 QEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD--- 367 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-EMTGYVATR 186 + QI G+ Y+ + +HRDL+ +N+ V E+ K+ DFGLAR +D E T + Sbjct: 368 --MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK 425 Query: 187 W---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT---DHIDQLKLILRLV 239 + + APE L + + D+WS G ++ EL T GR +PG + +DQ++ R+ Sbjct: 426 FPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP 484 Query: 240 GTP 242 P Sbjct: 485 CPP 487 >6F3F-A nrPDB Length = 455 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 68/243 (27%), Positives = 118/243 (48%), Gaps = 21/243 (8%) Query: 11 QELNKTIWEVPERYQNLS-PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTY 69 Q L K WE+P L +G G +G V T RVA+K L +P + + Sbjct: 175 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTL-KP--GTMSPEAFL 230 Query: 70 RELRLLKHMKHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 +E +++K ++HE ++ L V + P + E+ + + + + ++ +L D Sbjct: 231 QEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVD--- 287 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-EMTGYVATR 186 + QI G+ Y+ + +HRDL+ +N+ V E+ K+ DFGLAR +D E T + Sbjct: 288 --MSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK 345 Query: 187 W---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT---DHIDQLKLILRLV 239 + + APE L + + D+WS G ++ EL T GR +PG + +DQ++ R+ Sbjct: 346 FPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP 404 Query: 240 GTP 242 P Sbjct: 405 CPP 407 >5YKS-A nrPDB Length = 377 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 63/213 (29%), Positives = 106/213 (49%), Gaps = 12/213 (5%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G + V A TG +VAVK + + + ++E+R +K ++H N++ L +V Sbjct: 43 LGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEV 102 Query: 90 FTPARSLEEFNDVYLVTHLM-GADL-NNIVKCQK-LTDDHVQFLIYQILRGLKYIHSADI 146 L YL+ L G D+ + I+K ++ L +D + QI+ + Y H + Sbjct: 103 IDTQTKL------YLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHV 156 Query: 147 IHRDLKPSNLAVNEDCEL-KILDFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNQT 203 +HRDLKP N+ E L K+ DFG + ++T + Y APEI+L + Sbjct: 157 VHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPA 216 Query: 204 VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 VDIWS+G I+ L+ G+ F + + L +I+ Sbjct: 217 VDIWSLGVILFMLVCGQPPFQEANDSETLTMIM 249 >3DB8-A nrPDB Length = 317 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 84/307 (27%), Positives = 135/307 (43%), Gaps = 48/307 (15%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK-RTYRELRLLKHMKH 80 +RY +G G + D T A K + + H K + E+ + K + + Sbjct: 42 KRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDN 101 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQK-LTDDHVQFLIYQILRGL 138 +V+G F E+ + VY+V + L + K +K +T+ ++ + Q ++G+ Sbjct: 102 PHVVGFHGFF------EDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGV 155 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG-----YVATRWYRAPEI 193 +Y+H+ +IHRDLK NL +N+D ++KI DFGLA T E G T Y APE+ Sbjct: 156 QYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLA--TKIEFDGERKKDLCGTPNYIAPEV 213 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 + H + VDIWS+GCI+ LL G+ F +S Sbjct: 214 LCKKGHSFE-VDIWSLGCILYTLLVGKPPFE--------------------------TSC 246 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHD 313 YI+ K N +V NP+A L+ +ML D R + A+ L +F + Sbjct: 247 LKETYIRI-----KKNEYSVPRHINPVASALIRRMLHADPTLRPSVAELLTDEFFTSGYA 301 Query: 314 PDDEPVA 320 P P + Sbjct: 302 PMRLPTS 308 >4CZT-A nrPDB Length = 464 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 59/224 (26%), Positives = 106/224 (47%), Gaps = 16/224 (7%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK---RTYRELRLLKHMK 79 +Y+ +G G + V A + + G VA+K + + + ++ K + RE+ +K +K Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDK--EKVLKNKMIAQIKREISTMKLIK 69 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGL 138 H NVI + +V + +++ + G +L + I +L +D + Q++ + Sbjct: 70 HPNVIRMFEVMASKTKI-----YFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 124 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEMTGYVATRWYRAPEI 193 Y HS + HRDLKP NL ++ + LK+ DFGL+ D + T Y APE+ Sbjct: 125 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 184 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 + N + D+WS G I+ L+ G F ++ K I + Sbjct: 185 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK 228 >2PL0-A nrPDB Length = 289 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 66/218 (30%), Positives = 109/218 (50%), Gaps = 22/218 (10%) Query: 18 WEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 WEVP E + + +G+G +G V + +VAVK L Q + E L+K Sbjct: 18 WEVPRETLKLVERLGAGQFGEVWMGY-YNGHTKVAVKSLK---QGSMSPDAFLAEANLMK 73 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ---KLTDDHVQFLIY 132 ++H+ ++ L V T +Y++T M L + +K KLT + + + Sbjct: 74 QLQHQRLVRLYAVVTQ-------EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAA 126 Query: 133 QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-EMTGYVATRW---Y 188 QI G+ +I + IHRDL+ +N+ V++ KI DFGLAR +D E T ++ + Sbjct: 127 QIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKW 186 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPG 225 APE +N+ + D+WS G ++ E++T GR +PG Sbjct: 187 TAPE-AINYGTFTIKSDVWSFGILLTEIVTHGRIPYPG 223 >5D7A-A nrPDB Length = 308 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 65/243 (26%), Positives = 110/243 (45%), Gaps = 16/243 (6%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 VG+G YG V KTG A+K + K+ L+ H H N+ Sbjct: 25 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH--HRNIATYYGA 82 Query: 90 FTPARSLEEFNDVYLVTHLMGA----DLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSAD 145 F + ++LV GA DL K L ++ + ++ +ILRGL ++H Sbjct: 83 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHK 142 Query: 146 IIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM---TGYVATRWYRAPEIMLNWMH--- 199 +IHRD+K N+ + E+ E+K++DFG++ D + ++ T ++ APE++ + Sbjct: 143 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 202 Query: 200 -YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY 258 Y+ D+WS+G E+ G + L LI R P L K S+ +++ Sbjct: 203 TYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPR---NPAPRLKSKKWSKKFQSF 259 Query: 259 IQS 261 I+S Sbjct: 260 IES 262 >3A4O-X nrPDB Length = 286 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 68/226 (30%), Positives = 112/226 (49%), Gaps = 19/226 (8%) Query: 14 NKTIWEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYREL 72 +K WE+P E + + +G+G +G V + + +VAVK L +P + A E Sbjct: 4 DKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNS-TKVAVKTL-KPGTMSVQA--FLEEA 59 Query: 73 RLLKHMKHENVIGLLDVFT---PARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQF 129 L+K ++H+ ++ L V T P + E+ + + +D V KL D Q Sbjct: 60 NLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQ- 118 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-EMTGYVATRW- 187 I G+ YI + IHRDL+ +N+ V+E KI DFGLAR +D E T ++ Sbjct: 119 ----IAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFP 174 Query: 188 --YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHID 230 + APE +N+ + D+WS G ++ E++T G+ +PG + D Sbjct: 175 IKWTAPE-AINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNAD 219 >1ZXE-A nrPDB Length = 303 Score = 84.3 bits (207), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 58/242 (23%), Positives = 118/242 (48%), Gaps = 35/242 (14%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 ++ ++ +G GA+G V A + A+KK+ + + E+ LL + H+ V Sbjct: 8 FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKL---STILSEVMLLASLNHQYV 64 Query: 84 IGLL-------DVFTPARSLEEFNDVYL-VTHLMGADLNNIVKCQKLTDDHVQF--LIYQ 133 + + P ++++ + +++ + + L +++ + L ++ L Q Sbjct: 65 VRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQ 124 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH-----------------TD 176 IL L YIHS IIHR+LKP N+ ++E +KI DFGLA++ + Sbjct: 125 ILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSS 184 Query: 177 DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 D +T + T Y A E++ HYN+ +D++S+G I E+ ++P + ++++ ++ Sbjct: 185 DNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEM-----IYPFSTGMERVNILK 239 Query: 237 RL 238 +L Sbjct: 240 KL 241 >4AF3-A nrPDB Length = 292 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 78/286 (27%), Positives = 123/286 (43%), Gaps = 48/286 (16%) Query: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK----RTYRELRLLKHMKHENVI 84 P+G G +G+V A + K+ VA+K L F+S I + + RE+ + H+ H N++ Sbjct: 30 PLGKGKFGNVYLAREKKSHFIVALKVL---FKSQIEKEGVEHQLRREIEIQAHLHHPNIL 86 Query: 85 GLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIH 142 L + F R +YL+ G + K + ++ ++ L Y H Sbjct: 87 RLYNYFYDRRR------IYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCH 140 Query: 143 SADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-EMTGYVATRWYRAPEIMLNWMHYN 201 +IHRD+KP NL + ELKI DFG + H T Y PE++ MH N Sbjct: 141 GKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMH-N 199 Query: 202 QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQS 261 + VD+W +G + ELL G F H +E+ R ++ Sbjct: 200 EKVDLWCIGVLCYELLVGNPPFESASH-----------------------NETYRRIVKV 236 Query: 262 LTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 + P A+V GA DL+ K+L + +R+ AQ AH + Sbjct: 237 DLKFP----ASVPTGAQ----DLISKLLRHNPSERLPLAQVSAHPW 274 >2FO0-A nrPDB Length = 495 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 66/235 (28%), Positives = 112/235 (47%), Gaps = 20/235 (8%) Query: 3 QERPTFYRQELNKTIWEVPERYQNLS-PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 + +PT Y N WE+ + +G G YG V K L VAVK L + Sbjct: 197 RNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---ED 253 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKC 119 + + +E ++K +KH N++ LL V T Y++T M G L+ + +C Sbjct: 254 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPF------YIITEFMTYGNLLDYLREC 307 Query: 120 QKLTDDHVQ--FLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-HTD 176 + + V ++ QI ++Y+ + IHR+L N V E+ +K+ DFGL+R T Sbjct: 308 NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTG 367 Query: 177 DEMTGYVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTD 227 D T + ++ + APE L + ++ D+W+ G ++ E+ T G + +PG D Sbjct: 368 DTYTAHAGAKFPIKWTAPE-SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID 421 >5WAX-A nrPDB Length = 310 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 73/295 (24%), Positives = 124/295 (42%), Gaps = 44/295 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 +RY+ + +GSG +G + G VAVK + R + + RE+ + ++H Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKI---DENVQREIINHRSLRHP 67 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKY 140 N+I +V L ++ + G +L I + ++D +F Q++ G+ Y Sbjct: 68 NIIRFKEVILTPTHL-----AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 122 Query: 141 IHSADIIHRDLKPSNLAVNEDC--ELKILDFGLAR----HTDDEMTGYVATRWYRAPEIM 194 HS + HRDLK N ++ LKI DFG ++ H+ + T V T Y APE++ Sbjct: 123 CHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKST--VGTPAYIAPEVL 180 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQL-KLILRLVGTPGAELLKKISSE 253 L + + D+WS G + +L G F D K I R++G Sbjct: 181 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGV----------QY 230 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 S +Y+ +P DL+ ++ V + RIT + H +F Sbjct: 231 SIPDYVH----------------ISPECQDLISRIFVANPATRITIPEIRNHPWF 269 >6NPU-A nrPDB Length = 298 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 102/207 (49%), Gaps = 19/207 (9%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G YG V K L VAVK L + + + +E ++K +KH N++ LL V Sbjct: 34 LGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLGV 90 Query: 90 FTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQ--FLIYQILRGLKYIHSAD 145 T Y++T M G L+ + +C + + V ++ QI ++Y+ + Sbjct: 91 CTREPPF------YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKN 144 Query: 146 IIHRDLKPSNLAVNEDCELKILDFGLAR-HTDDEMTGYVATRW---YRAPEIMLNWMHYN 201 IHRDL N V E+ +K+ DFGL+R T D T + ++ + APE L + ++ Sbjct: 145 FIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE-SLAYNKFS 203 Query: 202 QTVDIWSVGCIMAELLT-GRTLFPGTD 227 D+W+ G ++ E+ T G + +PG D Sbjct: 204 IKSDVWAFGVLLWEIATYGMSPYPGID 230 >2DQ7-X nrPDB Length = 283 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 69/234 (29%), Positives = 119/234 (50%), Gaps = 24/234 (10%) Query: 15 KTIWEVP-ERYQNLSPVGSGAYGSV-CAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYREL 72 K +WE+P E Q + +G+G +G V ++ T +VA+K L + + E Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNT--KVAIKTLK---PGTMSPESFLEEA 55 Query: 73 RLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVK---CQKLTDDHVQ 128 +++K +KH+ ++ L V + EE +Y+VT M L + +K + L ++ Sbjct: 56 QIMKKLKHDKLVQLYAVVS-----EE--PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLV 108 Query: 129 FLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-EMTGYVATRW 187 + Q+ G+ YI + IHRDL+ +N+ V KI DFGLAR +D E T ++ Sbjct: 109 DMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKF 168 Query: 188 ---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILR 237 + APE L + + D+WS G ++ EL+T GR +PG ++ + L+ + R Sbjct: 169 PIKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVER 221 >4FR4-A nrPDB Length = 384 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 108/208 (51%), Gaps = 17/208 (8%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH---AKRTYRELRLLKHM 78 + ++ L +G G++G VC T A+K +++ Q + + ++EL++++ + Sbjct: 15 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNK--QKCVERNEVRNVFKELQIMQGL 72 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLN-NIVKCQKLTDDHVQFLIYQILR 136 +H ++ L S ++ D+++V L+ G DL ++ + ++ V+ I +++ Sbjct: 73 EHPFLVNLW------YSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVM 126 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVATRWYRAPEIM 194 L Y+ + IIHRD+KP N+ ++E + I DF +A + ++T T+ Y APE+ Sbjct: 127 ALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMF 186 Query: 195 LN--WMHYNQTVDIWSVGCIMAELLTGR 220 + Y+ VD WS+G ELL GR Sbjct: 187 SSRKGAGYSFAVDWWSLGVTAYELLRGR 214 >3HDN-A nrPDB Length = 373 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 67/252 (26%), Positives = 121/252 (48%), Gaps = 21/252 (8%) Query: 21 PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELR----LLK 76 P + L +G G++G V A + AVK L + ++I+ K + LLK Sbjct: 37 PSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQK--KAILKKKEEKHIMSERNVLLK 94 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQIL 135 ++KH ++GL F A L +++ ++ G +L ++ + + + +F +I Sbjct: 95 NVKHPFLVGLHFSFQTADKL-----YFVLDYINGGELFYHLQRERCFLEPRARFYAAEIA 149 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT---DDEMTGYVATRWYRAPE 192 L Y+HS +I++RDLKP N+ ++ + + DFGL + + + + T Y APE Sbjct: 150 SALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPE 209 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 + L+ Y++TVD W +G ++ E+L G F + + IL LK + Sbjct: 210 V-LHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN-----KPLQLKPNIT 263 Query: 253 ESARNYIQSLTQ 264 SAR+ ++ L Q Sbjct: 264 NSARHLLEGLLQ 275 >2XYN-A nrPDB Length = 292 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 64/207 (30%), Positives = 106/207 (51%), Gaps = 19/207 (9%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G YG V K L VAVK L + + + +E ++K +KH N++ LL V Sbjct: 40 LGGGQYGEVYVGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLGV 96 Query: 90 FTPARSLEEFNDVYLVTHLM--GADLNNIVKC--QKLTDDHVQFLIYQILRGLKYIHSAD 145 T LE Y+VT M G L+ + +C +++T + ++ QI ++Y+ + Sbjct: 97 CT----LEP--PFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKN 150 Query: 146 IIHRDLKPSNLAVNEDCELKILDFGLAR-HTDDEMTGYVATRW---YRAPEIMLNWMHYN 201 IHRDL N V E+ +K+ DFGL+R T D T + ++ + APE L + ++ Sbjct: 151 FIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE-SLAYNTFS 209 Query: 202 QTVDIWSVGCIMAELLT-GRTLFPGTD 227 D+W+ G ++ E+ T G + +PG D Sbjct: 210 IKSDVWAFGVLLWEIATYGMSPYPGID 236 >2HK5-A nrPDB Length = 270 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 69/241 (28%), Positives = 117/241 (48%), Gaps = 22/241 (9%) Query: 15 KTIWEVPERYQNL-SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELR 73 K WE+P L +G+G +G V A K +VAVK + +P + A E Sbjct: 7 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKH-TKVAVKTM-KPGSMSVEA--FLAEAN 62 Query: 74 LLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQKLTDDHVQFLI- 131 ++K ++H+ ++ L V T +Y++T M L + +K + + + LI Sbjct: 63 VMKTLQHDKLVKLHAVVTK-------EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID 115 Query: 132 --YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-EMTGYVATRW- 187 QI G+ +I + IHRDL+ +N+ V+ KI DFGLAR +D E T ++ Sbjct: 116 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP 175 Query: 188 --YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGA 244 + APE +N+ + D+WS G ++ E++T GR +PG + + ++ + R P Sbjct: 176 IKWTAPE-AINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP 234 Query: 245 E 245 E Sbjct: 235 E 235 >4U41-A nrPDB Length = 332 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 56/201 (27%), Positives = 92/201 (45%), Gaps = 13/201 (6%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 VG+G YG V KTG A+K + K L+ H H N+ Sbjct: 32 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSH--HRNIATYYGA 89 Query: 90 FTPARSLEEFNDVYLVTHLMGA----DLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSAD 145 F + ++LV GA DL K L +D + ++ +ILRGL ++H Sbjct: 90 FIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHH 149 Query: 146 IIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM---TGYVATRWYRAPEIMLNWMH--- 199 +IHRD+K N+ + E+ E+K++DFG++ D + ++ T ++ APE++ + Sbjct: 150 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 209 Query: 200 -YNQTVDIWSVGCIMAELLTG 219 Y+ D+WS G E+ G Sbjct: 210 TYDYRSDLWSCGITAIEMAEG 230 >3UC3-A nrPDB Length = 361 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 75/304 (24%), Positives = 129/304 (42%), Gaps = 44/304 (14%) Query: 13 LNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYREL 72 L+ I +RY + +GSG +G D T VAVK + R + RE+ Sbjct: 11 LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER---GAAIDENVQREI 67 Query: 73 RLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLI 131 + ++H N++ +V L ++ + G +L I + ++D +F Sbjct: 68 INHRSLRHPNIVRFKEVILTPTHL-----AIIMEYASGGELYERICNAGRFSEDEARFFF 122 Query: 132 YQILRGLKYIHSADIIHRDLKPSN--LAVNEDCELKILDFGLAR----HTDDEMTGYVAT 185 Q+L G+ Y HS I HRDLK N L + LKI DFG ++ H+ + T V T Sbjct: 123 QQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST--VGT 180 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 Y APE++L + + D+WS G + +L G +P D Sbjct: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVG--AYPFED------------------ 220 Query: 246 LLKKISSESARNYIQSLTQMPKMNFA-NVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304 E R+Y +++ ++ + ++ I +P L+ ++ V D RI+ + Sbjct: 221 ------PEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 Query: 305 HAYF 308 H++F Sbjct: 275 HSWF 278 >5EG3-A nrPDB Length = 334 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 73/247 (29%), Positives = 115/247 (46%), Gaps = 33/247 (13%) Query: 18 WEVPERYQNLS-PVGSGAYGSVCAAF-------DTKTGLRVAVKKLSRPFQSIIHAKRTY 69 WE P L P+G GA+G V A K + VAVK L + + Sbjct: 30 WEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKML-KDDATEKDLSDLV 88 Query: 70 RELRLLKHM-KHENVIGLLDVFT------------PARSLEEFNDVYLVTHL-MGADLNN 115 E+ ++K + KH+N+I LL T +L E+ + + D+N Sbjct: 89 SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINR 148 Query: 116 IVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT 175 + + Q D V YQ+ RG++Y+ S IHRDL N+ V E+ +KI DFGLAR Sbjct: 149 VPEEQMTFKDLVS-CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI 207 Query: 176 D------DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDH 228 + + G + +W APE + + ++ +Q+ D+WS G +M E+ T G + +PG Sbjct: 208 NNIDFFKETTNGRLPVKWM-APEALFDRVYTHQS-DVWSFGVLMWEIFTLGGSPYPGIPV 265 Query: 229 IDQLKLI 235 + KL+ Sbjct: 266 EELFKLL 272 >2BRG-A nrPDB Length = 297 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 59/195 (30%), Positives = 95/195 (48%), Gaps = 10/195 (5%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G GAYG V A + T VAVK + +++ + +E+ + K + HENV+ Sbjct: 15 LGEGAYGEVQLAVNRVTEEAVAVKIVDMK-RAVDCPENIKKEICINKMLNHENVVK---- 69 Query: 90 FTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHR 149 F R ++L G + I + + Q +Q++ G+ Y+H I HR Sbjct: 70 FYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHR 129 Query: 150 DLKPSNLAVNEDCELKILDFGLA---RHTDDE--MTGYVATRWYRAPEIMLNWMHYNQTV 204 D+KP NL ++E LKI DFGLA R+ + E + T Y APE++ + + V Sbjct: 130 DIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPV 189 Query: 205 DIWSVGCIMAELLTG 219 D+WS G ++ +L G Sbjct: 190 DVWSCGIVLTAMLAG 204 >5VO2-A nrPDB Length = 300 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 69/220 (31%), Positives = 105/220 (47%), Gaps = 25/220 (11%) Query: 14 NKTIWEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRE- 71 ++ +WEVP E +L VGSGA G+V G VAVKK+ R +E Sbjct: 3 SEDLWEVPFEEILDLQWVGSGAQGAV--FLGRFHGEEVAVKKV-----------RDLKET 49 Query: 72 -LRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQF 129 ++ L+ +KH N+I V T A L+ L +++ + +T + Sbjct: 50 DIKHLRKLKHPNIITFKGVCTQAPCY-----CILMEFCAQGQLYEVLRAGRPVTPSLLVD 104 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT--GYVATRW 187 I G+ Y+H IIHRDLK N+ + D +KI DFG ++ D+ T + T Sbjct: 105 WSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVA 164 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTD 227 + APE++ N ++ VDIWS G ++ ELLTG + D Sbjct: 165 WMAPEVIRN-EPVSEKVDIWSFGVVLWELLTGEIPYKDVD 203 >2PSQ-A nrPDB Length = 370 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 73/252 (28%), Positives = 116/252 (46%), Gaps = 43/252 (17%) Query: 18 WEVPERYQNLS-PVGSGAYGSVCAAF-------DTKTGLRVAVKKLS-----RPFQSIIH 64 WE P L P+G G +G V A K + VAVK L + ++ Sbjct: 76 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS 135 Query: 65 AKRTYRELRLLKHM-KHENVIGLLDVFT---PARSLEEFNDVYLVTHLMGA--------- 111 E+ ++K + KH+N+I LL T P + E+ + + A Sbjct: 136 ------EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS 189 Query: 112 -DLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFG 170 D+N + + Q D V YQ+ RG++Y+ S IHRDL N+ V E+ +KI DFG Sbjct: 190 YDINRVPEEQMTFKDLVS-CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 248 Query: 171 LARHTDD------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLF 223 LAR ++ G + +W APE + + ++ +Q+ D+WS G +M E+ T G + + Sbjct: 249 LARDINNIDYYKKTTNGRLPVKWM-APEALFDRVYTHQS-DVWSFGVLMWEIFTLGGSPY 306 Query: 224 PGTDHIDQLKLI 235 PG + KL+ Sbjct: 307 PGIPVEELFKLL 318 >2W4O-A nrPDB Length = 349 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 85/287 (29%), Positives = 123/287 (42%), Gaps = 44/287 (15%) Query: 28 SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLL 87 S +G GA V T A+K L + + K E+ +L + H N+I L Sbjct: 59 SELGRGATSIVYRCKQKGTQKPYALKVLKK----TVDKKIVRTEIGVLLRLSHPNIIKLK 114 Query: 88 DVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSAD 145 ++F E ++ LV L+ G + IV+ ++ + QIL + Y+H Sbjct: 115 EIF------ETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENG 168 Query: 146 IIHRDLKPSNL---AVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWMHY 200 I+HRDLKP NL D LKI DFGL++ + + M T Y APEI L Y Sbjct: 169 IVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEI-LRGCAY 227 Query: 201 NQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQ 260 VD+WSVG I LL G F + DQ + ++I + +I Sbjct: 228 GPEVDMWSVGIITYILLCGFEPFY-DERGDQF-------------MFRRILN-CEYYFIS 272 Query: 261 SLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 +N A DL+ K++VLD KR+T QAL H + Sbjct: 273 PWWDEVSLN-----------AKDLVRKLIVLDPKKRLTTFQALQHPW 308 >5J5T-A nrPDB Length = 370 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 81/340 (23%), Positives = 155/340 (45%), Gaps = 22/340 (6%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLS-RPFQSIIHAKRTYRELRLLKHMKH 80 E ++ + +GSG YG V A + TG A+K + P + ++ E+ ++K KH Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQ---EIIMMKDCKH 60 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGLK 139 N++ + L + G L +I L++ + ++ + L+GL Sbjct: 61 PNIVAYFGSYLRRDKL-----WICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLY 115 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH---TDDEMTGYVATRWYRAPEIML- 195 Y+HS +HRD+K +N+ + ++ +K+ DFG++ T + ++ T ++ APE+ Sbjct: 116 YLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAV 175 Query: 196 -NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 YNQ D+W+VG EL + + L L+ + P K S S Sbjct: 176 ERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNS 235 Query: 255 ARNYIQ-SLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHD 313 ++++ +LT+ PK + +P L + L ++ ++ H+ + + D Sbjct: 236 FHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPD---HSTYHDFDD 292 Query: 314 PDDEP-VADPYDQSFESRDLLIDEWKS-LTYDEVISFVPP 351 D EP VA P+ SR++ ++ +S +T+ +V F PP Sbjct: 293 DDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQV-KFDPP 331 >6CQF-A nrPDB Length = 297 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 54/202 (26%), Positives = 101/202 (50%), Gaps = 15/202 (7%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 + Y L +G G YG V A D +G VA+K + + + +E+ +LK +H Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ--KEILILKTCRHA 73 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQ-KLTDDHVQFLIYQILRGLK 139 N++ + + L ++ GA L +I + L++ + ++ ++L+GL Sbjct: 74 NIVAYHGSYLWLQKL------WICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 127 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT---GYVATRWYRAPEIMLN 196 Y+HS IHRD+K +N+ +N+ E+++ DFG++ + ++ T ++ APE+ Sbjct: 128 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAV 187 Query: 197 WMH--YNQTVDIWSVGCIMAEL 216 + YN+ DIWS+G EL Sbjct: 188 ALKGGYNELCDIWSLGITAIEL 209 >3DAK-A nrPDB Length = 290 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 79/311 (25%), Positives = 135/311 (43%), Gaps = 58/311 (18%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 Y+ +GSGA V AA+ +VA+K+++ + +E++ + H N+ Sbjct: 12 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLE-KCQTSMDELLKEIQAMSQCHHPNI 70 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDH---------VQFLIYQ 133 + F ++++LV L+ G + +I+K +H + ++ + Sbjct: 71 VSYYTSFVVK------DELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 124 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMT------GYVAT 185 +L GL+Y+H IHRD+K N+ + ED ++I DFG++ T ++T +V T Sbjct: 125 VLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGT 184 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR------LV 239 + APE+M Y+ DIWS G EL TG + + L L L+ Sbjct: 185 PCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLET 244 Query: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITA 299 G E+LKK Y +S +M + L+K D +KR TA Sbjct: 245 GVQDKEMLKK--------YGKSFRKMISL---------------CLQK----DPEKRPTA 277 Query: 300 AQALAHAYFAQ 310 A+ L H +F + Sbjct: 278 AELLRHKFFQK 288 >3LM0-A nrPDB Length = 327 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 79/310 (25%), Positives = 139/310 (44%), Gaps = 45/310 (14%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH-ENVIGLLD 88 +G G + V TG A K L + + E+ +L+ K VI L + Sbjct: 37 LGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHE 96 Query: 89 VFTPARSLEEFNDVYLVTHLMGADLNNIVK---CQKLTDDHVQFLIYQILRGLKYIHSAD 145 V+ + + ++ + G ++ ++ + ++++ V LI QIL G+ Y+H + Sbjct: 97 VYENTSEI-----ILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNN 151 Query: 146 IIHRDLKPSNLAVNED---CELKILDFGLARHTDD--EMTGYVATRWYRAPEIMLNWMHY 200 I+H DLKP N+ ++ ++KI+DFG++R E+ + T Y APEI LN+ Sbjct: 152 IVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEI-LNYDPI 210 Query: 201 NQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQ 260 D+W++G I LLT + F G D+ E+ N Q Sbjct: 211 TTATDMWNIGIIAYMLLTHTSPFVGEDN-----------------------QETYLNISQ 247 Query: 261 SLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVA 320 + F++V + LA D ++ +LV + +KR TA L+H++ Q+ D E + Sbjct: 248 VNVDYSEETFSSV----SQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQW---DFENLF 300 Query: 321 DPYDQSFESR 330 P + S S+ Sbjct: 301 HPEETSSSSQ 310 >3GQL-A nrPDB Length = 326 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 76/253 (30%), Positives = 120/253 (47%), Gaps = 45/253 (17%) Query: 18 WEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGL---------RVAVKKLS-----RPFQSI 62 WE+P +R P+G GA+G V A GL +VAVK L + + Sbjct: 23 WELPRDRLVLGKPLGEGAFGQVVLA--EAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDL 80 Query: 63 IHAKRTYRELRLLKHM-KHENVIGLLDVFT---PARSLEEF-NDVYLVTHLMGADLNNIV 117 I E+ ++K + KH+N+I LL T P + E+ + L +L + Sbjct: 81 IS------EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLE 134 Query: 118 KC--------QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDF 169 C ++L+ + YQ+ RG++Y+ S IHRDL N+ V ED +KI DF Sbjct: 135 YCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF 194 Query: 170 GLAR---HTD---DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL 222 GLAR H D G + +W APE + + ++ +Q+ D+WS G ++ E+ T G + Sbjct: 195 GLARDIHHIDYYKKTTNGRLPVKWM-APEALFDRIYTHQS-DVWSFGVLLWEIFTLGGSP 252 Query: 223 FPGTDHIDQLKLI 235 +PG + KL+ Sbjct: 253 YPGVPVEELFKLL 265 >5H2U-A nrPDB Length = 267 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 59/215 (27%), Positives = 113/215 (52%), Gaps = 24/215 (11%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E + +GSG +G V K ++VA+K +SR +++H + E++ +K ++H+ Sbjct: 6 EEFTLCRKLGSGYFGEVFEGL-WKDRVQVAIKVISR--DNLLHQQMLQSEIQAMKKLRHK 62 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQF------LIYQIL 135 +++ L V + + VY++T LM ++++ + +D+ V + +Q+ Sbjct: 63 HILALYAVVSVG------DPVYIITELMAK--GSLLELLRDSDEKVLPVSELLDIAWQVA 114 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM----TGYVATRWYRAP 191 G+ Y+ S + IHRDL N+ V E+ K+ DFGLAR +++ + +W AP Sbjct: 115 EGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKW-TAP 173 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPG 225 E L+ HY+ D+WS G ++ E+ + G+ +PG Sbjct: 174 E-ALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPG 207 >5LOH-A nrPDB Length = 341 Score = 80.5 bits (197), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 66/216 (30%), Positives = 105/216 (48%), Gaps = 25/216 (11%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR---ELRLLKHM 78 E + + P+ GA+G V K G AVK + + +I+ T++ E L Sbjct: 36 EEFSIVKPISRGAFGKVY--LGQKGGKLYAVKVVKK--ADMINKNMTHQVQAERDALALS 91 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVT-HLMGADLNNIVKCQKLTDDHVQF-LIYQILR 136 K ++ L SL+ N+VYLV +L+G D+ +++ D+ + I ++ Sbjct: 92 KSPFIVHLY------YSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVAL 145 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT---DDEMTGYVATRW------ 187 L Y+H IIHRDLKP N+ ++ + +K+ DFGL++ T D M + TR Sbjct: 146 ALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPD 205 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLF 223 Y APE++L H VD W++G + E LTG F Sbjct: 206 YLAPELLLGRAH-GPAVDWWALGVCLFEFLTGIPPF 240 >4QMW-A nrPDB Length = 310 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 69/290 (23%), Positives = 133/290 (45%), Gaps = 24/290 (8%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E + L +G G++G V D +T VA+K + ++ + +E+ +L Sbjct: 29 ELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDL-EEAEDEIEDIQQEITVLSQCDSP 87 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 V + L++ ++ +L G ++++ L + + ++ +IL+GL Y+ Sbjct: 88 YVTKYYGSY-----LKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYL 142 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD---EMTGYVATRWYRAPEIMLNWM 198 HS IHRD+K +N+ ++E E+K+ DFG+A D + +V T ++ APE+ + Sbjct: 143 HSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEV-IKQS 201 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY 258 Y+ DIWS+G EL G P + +K +L L+ L+ S+ + + Sbjct: 202 AYDSKADIWSLGITAIELARGE---PPHSELHPMK-VLFLIPKNNPPTLEGNYSKPLKEF 257 Query: 259 IQS-LTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 +++ L + P P A +LL+ +L + K+ + L Y Sbjct: 258 VEACLNKEPSF---------RPTAKELLKHKFILRNAKKTSYLTELIDRY 298 >4TNB-A nrPDB Length = 590 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 56/202 (27%), Positives = 97/202 (48%), Gaps = 12/202 (5%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRP-FQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 +G G +G VCA TG A K+L + + E ++L+ + + V+ L Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 Query: 89 VFTPARSLEEFNDVYLVTHLMGADLNNIV---KCQKLTDDHVQFLIYQILRGLKYIHSAD 145 + +L ++T + G DL + ++ F +IL GL+ +H + Sbjct: 252 AYETKDAL-----CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHEN 306 Query: 146 IIHRDLKPSNLAVNEDCELKILDFGLARHT--DDEMTGYVATRWYRAPEIMLNWMHYNQT 203 ++RDLKP N+ +++ ++I D GLA D + G V T Y APE+ LN Y + Sbjct: 307 TVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV-LNNQRYGLS 365 Query: 204 VDIWSVGCIMAELLTGRTLFPG 225 D W +GC++ E++ G++ F G Sbjct: 366 PDYWGLGCLIYEMIEGQSPFRG 387 >3CJF-A nrPDB Length = 309 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 71/240 (29%), Positives = 114/240 (47%), Gaps = 26/240 (10%) Query: 10 RQELNKTIWEVPERYQNLS-PVGSGAYGSVCAAF-----DTKTGLRVAVKKLSRPFQSII 63 R + + WE P NL P+G GA+G V A T T VAVK L Sbjct: 14 RLPYDASKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE 73 Query: 64 HAKRTYRELRLLKHMKHE-NVIGLLDVFT----PARSLEEFNDVYLVTHLMGADLNNIVK 118 H + EL++L H+ H NV+ LL T P + EF ++ + + N V Sbjct: 74 H-RALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVP 132 Query: 119 CQKLTDD-----HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR 173 + L D H+ +Q+ +G++++ S IHRDL N+ ++E +KI DFGLAR Sbjct: 133 YKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLAR 192 Query: 174 --HTDDEMT----GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT 226 + D + + +W APE + + ++ Q+ D+WS G ++ E+ + G + +PG Sbjct: 193 DIYKDPDYVRKGDARLPLKWM-APETIFDRVYTIQS-DVWSFGVLLWEIFSLGASPYPGV 250 >1AD5-A nrPDB Length = 438 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 67/237 (28%), Positives = 113/237 (47%), Gaps = 24/237 (10%) Query: 15 KTIWEVPERYQNL-SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELR 73 K WE+P L +G+G +G V A K +VAVK + +P + A E Sbjct: 174 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKH-TKVAVKTM-KPGSMSVEA--FLAEAN 229 Query: 74 LLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQKLTDDHVQFLI- 131 ++K ++H+ ++ L V T +Y++T M L + +K + + + LI Sbjct: 230 VMKTLQHDKLVKLHAVVTK-------EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID 282 Query: 132 --YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYR 189 QI G+ +I + IHRDL+ +N+ V+ KI DFGLAR + +W Sbjct: 283 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLAR-----VGAKFPIKW-T 336 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAE 245 APE +N+ + D+WS G ++ E++T GR +PG + + ++ + R P E Sbjct: 337 APE-AINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE 392 >3UDB-A nrPDB Length = 317 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 67/293 (22%), Positives = 128/293 (43%), Gaps = 40/293 (13%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 +RY+ + +G+G +G D + VAVK + R + + KR E+ + ++H Sbjct: 19 DRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKR---EIINHRSLRHP 75 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKY 140 N++ +V L ++ + G +L I + ++D +F Q++ G+ Y Sbjct: 76 NIVRFKEVILTPTHL-----AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 Query: 141 IHSADIIHRDLKPSN--LAVNEDCELKILDFGLARHT--DDEMTGYVATRWYRAPEIMLN 196 H+ + HRDLK N L + LKI DFG ++ + + V T Y APE++L Sbjct: 131 AHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLK 190 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 256 + + D+WS G + +L G +P D E + Sbjct: 191 KEYDGKVADVWSCGVTLYVMLVG--AYPFED------------------------PEEPK 224 Query: 257 NYIQSLTQMPKMNFA-NVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 N+ +++ ++ + +A ++ +P L+ ++ V D KRI+ + H +F Sbjct: 225 NFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >3ZUT-A nrPDB Length = 362 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 69/295 (23%), Positives = 130/295 (44%), Gaps = 44/295 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 +RY+ + +GSG +G D ++ VAVK + R + + KR E+ + ++H Sbjct: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR---EIINHRSLRHP 75 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKY 140 N++ +V L ++ + G +L I + ++D +F Q++ G+ Y Sbjct: 76 NIVRFKEVILTPTHL-----AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 Query: 141 IHSADIIHRDLKPSN--LAVNEDCELKILDFGLAR----HTDDEMTGYVATRWYRAPEIM 194 H+ + HRDLK N L + LKI FG ++ H+ + T V T Y APE++ Sbjct: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKST--VGTPAYIAPEVL 188 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 L + + D+WS G + +L G +P D E Sbjct: 189 LKKEYDGKVADVWSCGVTLYVMLVG--AYPFED------------------------PEE 222 Query: 255 ARNYIQSLTQMPKMNFA-NVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 +N+ +++ ++ + +A ++ +P L+ ++ V D KRI+ + H +F Sbjct: 223 PKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >5A46-A nrPDB Length = 386 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 75/253 (29%), Positives = 117/253 (46%), Gaps = 45/253 (17%) Query: 18 WEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGL---------RVAVKKLS-----RPFQSI 62 WE+P +R P+G G +G V A GL +VAVK L + + Sbjct: 35 WELPRDRLVLGKPLGEGCFGQVVLA--EAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDL 92 Query: 63 IHAKRTYRELRLLKHM-KHENVIGLLDVFTPARSL----EEFNDVYLVTHLMGADLNNIV 117 I E+ ++K + KH+N+I LL T L E + L +L + Sbjct: 93 IS------EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLE 146 Query: 118 KC--------QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDF 169 C ++L+ + YQ+ RG++Y+ S IHRDL N+ V ED +KI DF Sbjct: 147 YCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF 206 Query: 170 GLAR---HTD---DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL 222 GLAR H D G + +W APE + + ++ +Q+ D+WS G ++ E+ T G + Sbjct: 207 GLARDIHHIDYYKKTTNGRLPVKWM-APEALFDRIYTHQS-DVWSFGVLLWEIFTLGGSP 264 Query: 223 FPGTDHIDQLKLI 235 +PG + KL+ Sbjct: 265 YPGVPVEELFKLL 277 >2UV2-A nrPDB Length = 325 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 71/299 (23%), Positives = 128/299 (42%), Gaps = 50/299 (16%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 WE+ + +G GA+G V A + +T + A K + + + E+ +L Sbjct: 39 WEI------IGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV--EIDILAS 90 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC--QKLTDDHVQFLIYQIL 135 H N++ LLD F E N L+ G ++ ++ + LT+ +Q + Q L Sbjct: 91 CDHPNIVKLLDAF-----YYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTL 145 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA---RHTDDEMTGYVATRWYRAPE 192 L Y+H IIHRDLK N+ D ++K+ DFG++ T ++ T ++ APE Sbjct: 146 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 205 Query: 193 IMLNWMH----YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 +++ Y+ D+WS+G + E+ + P ++ ++++L++ + L + Sbjct: 206 VVMCETSKDRPYDYKADVWSLGITLIEM---AEIEPPHHELNPMRVLLKIAKSEPPTLAQ 262 Query: 249 KISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 S NF D L+K L + D R T +Q L H + Sbjct: 263 PSRWSS--------------NFK-----------DFLKKCLEKNVDARWTTSQLLQHPF 296 >5O0Y-A nrPDB Length = 579 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 77/226 (34%), Positives = 108/226 (47%), Gaps = 28/226 (12%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVK-----KLSRPFQSIIHAKRTYRELRLLK 76 +RY L +G G + V AFD VAVK K R + + K RE R+ K Sbjct: 284 DRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHK 343 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL-TDDHVQFLIYQIL 135 + H ++ L D F SL+ + ++ + G DL+ +K KL ++ + +I QI+ Sbjct: 344 ELDHPRIVKLYDYF----SLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIV 399 Query: 136 RGLKYIHSAD--IIHRDLKPSN-LAVNEDC--ELKILDFGLARHTDD---------EMTG 181 LKY++ IIH DLKP N L VN E+KI DFGL++ DD E+T Sbjct: 400 NALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTS 459 Query: 182 YVA-TRWYRAPEIMLNWMH---YNQTVDIWSVGCIMAELLTGRTLF 223 A T WY PE + + VD+WSVG I + L GR F Sbjct: 460 QGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF 505 >6CKI-A nrPDB Length = 316 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 76/297 (25%), Positives = 128/297 (43%), Gaps = 38/297 (12%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G GA+ V + T AVK + + I R +RE+ +L + G +V Sbjct: 21 LGEGAHARVQTCINLITSQEYAVKIIEKQPGHI--RSRVFREVEMLYQCQ-----GHRNV 73 Query: 90 FTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADII 147 EE + YLV M G+ L++I K + + ++ + L ++H+ I Sbjct: 74 LELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIA 133 Query: 148 HRDLKPSNLAV---NEDCELKILDFGLARH----------TDDEMTGYVATRWYRAPEIM 194 HRDLKP N+ N+ +KI DFGL + E+ + Y APE++ Sbjct: 134 HRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVV 193 Query: 195 LNWMH----YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250 + Y++ D+WS+G I+ LL+G F G D G E Sbjct: 194 EAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSD--------CGWDRGEACPAC 245 Query: 251 SSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 + + + + P ++A++ A DL+ K+LV D+ +R++AAQ L H + Sbjct: 246 QNMLFESIQEGKYEFPDKDWAHISCAAK----DLISKLLVRDAKQRLSAAQVLQHPW 298 >2W1I-A nrPDB Length = 326 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 63/206 (30%), Positives = 99/206 (48%), Gaps = 22/206 (10%) Query: 27 LSPVGSGAYGSV--CA--AFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 L +G G +GSV C TG VAVKKL + H + RE+ +LK ++H+N Sbjct: 46 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE--HLRDFEREIEILKSLQHDN 103 Query: 83 VIGLLDV-FTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIY--QILRGLK 139 ++ V ++ R N ++ +L L + ++ K DH++ L Y QI +G++ Sbjct: 104 IVKYKGVCYSAGRR----NLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGME 159 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATR-------WYRAPE 192 Y+ + IHRDL N+ V + +KI DFGL + + Y WY APE Sbjct: 160 YLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY-APE 218 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLT 218 L ++ D+WS G ++ EL T Sbjct: 219 -SLTESKFSVASDVWSFGVVLYELFT 243 >3A8W-A nrPDB Length = 345 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 81/335 (24%), Positives = 152/335 (45%), Gaps = 49/335 (14%) Query: 27 LSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM-----KHE 81 L +G G+Y V KT A+K + + +++ ++ KH+ H Sbjct: 14 LRVIGRGSYAKVLLVRLKKTDRIYAMKVVKK---ELVNDDEDIDWVQTEKHVFEQASNHP 70 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLN-NIVKCQKLTDDHVQFLIYQILRGLKY 140 ++GL F L +++ ++ G DL ++ + +KL ++H +F +I L Y Sbjct: 71 FLVGLHSCFQTESRL-----FFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNY 125 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT---DDEMTGYVATRWYRAPEIMLNW 197 +H II+RDLK N+ ++ + +K+ D+G+ + D + + T Y APEI L Sbjct: 126 LHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEI-LRG 184 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLF---PGTDHIDQ------LKLIL-------RLVGT 241 Y +VD W++G +M E++ GR+ F +D+ DQ ++IL R + Sbjct: 185 EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSV 244 Query: 242 PGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAV----DLLEKMLVLDSDKRI 297 A +LK ++ + + L P+ FA+ I +P D++E+ V+ K Sbjct: 245 KAASVLKSFLNKDPK---ERLGCHPQTGFAD--IQGHPFFRNVDWDMMEQKQVVPPFKPN 299 Query: 298 TAAQALAHAYFAQYHD------PDDEPVADPYDQS 326 + + + +Q+ + PDD+ + DQS Sbjct: 300 ISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQS 334 >3TT0-A nrPDB Length = 382 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 74/258 (28%), Positives = 118/258 (45%), Gaps = 55/258 (21%) Query: 18 WEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGL---------RVAVKKLS-----RPFQSI 62 WE+P +R P+G GA+G V A GL +VAVK L + + Sbjct: 64 WELPRDRLVLGKPLGEGAFGQVVLA--EAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDL 121 Query: 63 IHAKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 I E+ ++K + KH+N+I LL T L +V + +L ++ ++ Sbjct: 122 IS------EMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLQARR 170 Query: 122 -----------------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL 164 L+ + YQ+ RG++Y+ S IHRDL N+ V ED + Sbjct: 171 PPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM 230 Query: 165 KILDFGLAR---HTD---DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 KI DFGLAR H D G + +W APE + + ++ +Q+ D+WS G ++ E+ T Sbjct: 231 KIADFGLARDIHHIDYYKKTTNGRLPVKWM-APEALFDRIYTHQS-DVWSFGVLLWEIFT 288 Query: 219 -GRTLFPGTDHIDQLKLI 235 G + +PG + KL+ Sbjct: 289 LGGSPYPGVPVEELFKLL 306 >3IO7-A nrPDB Length = 313 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 63/206 (30%), Positives = 99/206 (48%), Gaps = 22/206 (10%) Query: 27 LSPVGSGAYGSV--CA--AFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 L +G G +GSV C TG VAVKKL + H + RE+ +LK ++H+N Sbjct: 33 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE--HLRDFEREIEILKSLQHDN 90 Query: 83 VIGLLDV-FTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIY--QILRGLK 139 ++ V ++ R N ++ +L L + ++ K DH++ L Y QI +G++ Sbjct: 91 IVKYKGVCYSAGRR----NLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGME 146 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATR-------WYRAPE 192 Y+ + IHRDL N+ V + +KI DFGL + + Y WY APE Sbjct: 147 YLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY-APE 205 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLT 218 L ++ D+WS G ++ EL T Sbjct: 206 -SLTESKFSVASDVWSFGVVLYELFT 230 >4XCU-A nrPDB Length = 300 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 72/251 (28%), Positives = 122/251 (48%), Gaps = 45/251 (17%) Query: 17 IWEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR----- 70 +WE P +R P+G G +G V A G+ A RP Q+ A + + Sbjct: 11 LWEFPRDRLVLGKPLGEGCFGQVVRA--EAFGMDPA-----RPDQASTVAVKMLKDNASD 63 Query: 71 --------ELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 E+ ++K + +H+N+I LL V T +E +V +L ++ ++ Sbjct: 64 KDLADLVSEMEVMKLIGRHKNIINLLGVCT-----QEGPLYVIVECAAKGNLREFLRARR 118 Query: 122 ---LTDDHVQFLI-----YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR 173 ++ + F + YQ+ RG++Y+ S IHRDL N+ V ED +KI DFGLAR Sbjct: 119 PPGSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLAR 178 Query: 174 ---HTD---DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT 226 H D G + +W APE + + ++ +Q+ D+WS G ++ E+ T G + +PG Sbjct: 179 GVHHIDYYKKTSNGRLPVKWM-APEALFDRVYTHQS-DVWSFGILLWEIFTLGGSPYPGI 236 Query: 227 DHIDQLKLILR 237 +++L +LR Sbjct: 237 P-VEELFSLLR 246 >4K33-A nrPDB Length = 325 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 66/254 (25%), Positives = 113/254 (44%), Gaps = 47/254 (18%) Query: 18 WEVPERYQNLS-PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRT-------- 68 WE+ L P+G GA+G V A + + + ++P + + Sbjct: 31 WELSRARLTLGKPLGEGAFGQVVMA----EAIGIDKDRAAKPVTVAVKMLKDDATDKDLS 86 Query: 69 --YRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK---- 121 E+ ++K + KH+N+I LL T L LV + +L ++ ++ Sbjct: 87 DLVSEMEMMKMIGKHKNIINLLGACTQGGPL-----YVLVEYAAKGNLREFLRARRPPGL 141 Query: 122 -------------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILD 168 LT + YQ+ RG++Y+ S IHRDL N+ V ED +KI D Sbjct: 142 DYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIAD 201 Query: 169 FGLAR------HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRT 221 FGLAR + + G + +W APE + + ++ +Q+ D+WS G ++ E+ T G + Sbjct: 202 FGLARDVHNLDYYKETTNGRLPVKWM-APEALFDRVYTHQS-DVWSFGVLLWEIFTLGGS 259 Query: 222 LFPGTDHIDQLKLI 235 +PG + KL+ Sbjct: 260 PYPGIPVEELFKLL 273 >2WQN-A nrPDB Length = 310 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 103/208 (49%), Gaps = 21/208 (10%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR---TYRELRLLKHMKHENVIGL 86 +G G + V A G+ VA+KK+ ++ AK +E+ LLK + H NVI Sbjct: 40 IGRGQFSEVYRAACLLDGVPVALKKVQ--IFDLMDAKARADCIKEIDLLKQLNHPNVIKY 97 Query: 87 LDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQK-----LTDDHVQFLIYQILRGLKY 140 F E N++ +V L A DL+ ++K K + + V Q+ L++ Sbjct: 98 YASFI------EDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEH 151 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG---YVATRWYRAPEIMLNW 197 +HS ++HRD+KP+N+ + +K+ D GL R + T V T +Y +PE ++ Sbjct: 152 MHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPE-RIHE 210 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPG 225 YN DIWS+GC++ E+ ++ F G Sbjct: 211 NGYNFKSDIWSLGCLLYEMAALQSPFYG 238 >3LLT-A nrPDB Length = 360 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 72/328 (21%), Positives = 136/328 (41%), Gaps = 54/328 (16%) Query: 27 LSPVGSGAYGSV--CAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVI 84 + +G G +G V C D K V V + + + + E +LK ++++++ Sbjct: 40 IRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKY-----TRSAKIEADILKKIQNDDIN 94 Query: 85 GLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQ---FLIYQILRGLKYI 141 V + + ++ + L+ +G L I+ H++ +IL+ L Y+ Sbjct: 95 NNNIVKYHGKFMY-YDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYL 153 Query: 142 HSADIIHRDLKPSNLAVNE-------------------------DCELKILDFGLARHTD 176 + H DLKP N+ +++ +K++DFG A Sbjct: 154 RKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKS 213 Query: 177 DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 D + TR YRAPE++LN + ++ + D+WS GC++AEL TG LF +H++ L ++ Sbjct: 214 DYHGSIINTRQYRAPEVILN-LGWDVSSDMWSFGCVLAELYTGSLLFRTHEHMEHLAMME 272 Query: 237 RLVGTPGAELLKKISSESARNY----------------IQSLTQMPKMNFANVFIGANPL 280 ++ +L + + + Y I S+ + K I + L Sbjct: 273 SIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKC-LPLYKIIKHEL 331 Query: 281 AVDLLEKMLVLDSDKRITAAQALAHAYF 308 D L +L +D R + A+ L H + Sbjct: 332 FCDFLYSILQIDPTLRPSPAELLKHKFL 359 >6E9W-A nrPDB Length = 443 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 61/212 (28%), Positives = 97/212 (45%), Gaps = 17/212 (8%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTY--RELRLLKHMK 79 E Y+ + +G GA+G V T A+K LS+ F+ I + + E ++ Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSK-FEMIKRSDSAFFWEERDIMAFAN 160 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQILRGL 138 V+ L F R L Y+V M G DL N++ + + +F +++ L Sbjct: 161 SPWVVQLFYAFQDDRYL------YMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLAL 214 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE----MTGYVATRWYRAPEIM 194 IHS IHRD+KP N+ +++ LK+ DFG + E V T Y +PE++ Sbjct: 215 DAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVL 274 Query: 195 LNW---MHYNQTVDIWSVGCIMAELLTGRTLF 223 + +Y + D WSVG + E+L G T F Sbjct: 275 KSQGGDGYYGRECDWWSVGVFLYEMLVGDTPF 306 >2XIK-A nrPDB Length = 294 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 52/201 (25%), Positives = 98/201 (48%), Gaps = 10/201 (4%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E + L +G G++G V D T VA+K + ++ + +E+ +L Sbjct: 19 ELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDL-EEAEDEIEDIQQEITVLSQCDSP 77 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 + + + L ++ +L G +++K L + ++ ++ +IL+GL Y+ Sbjct: 78 YITRYFGSYLKSTKL-----WIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYL 132 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD---EMTGYVATRWYRAPEIMLNWM 198 HS IHRD+K +N+ ++E ++K+ DFG+A D + +V T ++ APE+ + Sbjct: 133 HSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEV-IKQS 191 Query: 199 HYNQTVDIWSVGCIMAELLTG 219 Y+ DIWS+G EL G Sbjct: 192 AYDFKADIWSLGITAIELAKG 212 >5HVK-A nrPDB Length = 315 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 100/209 (47%), Gaps = 31/209 (14%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTY-RELRLLKHMKHENVIGLLD 88 +G G +G +TG + +K+L R F +RT+ +E+++++ ++H NV+ + Sbjct: 22 LGKGCFGQAIKVTHRETGEVMVMKELIR-FDE--ETQRTFLKEVKVMRCLEHPNVLKFIG 78 Query: 89 VFTPARSLEEFNDVYLVTHLMGADLNNIVKC---QKLTDDHVQFLIYQILRGLKYIHSAD 145 V + L ++ ++ G L I+K Q V F I G+ Y+HS + Sbjct: 79 VLYKDKRLN-----FITEYIKGGTLRGIIKSMDSQYPWSQRVSF-AKDIASGMAYLHSMN 132 Query: 146 IIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT-----------------GYVATRWY 188 IIHR+L N V E+ + + DFGLAR DE T V ++ Sbjct: 133 IIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYW 192 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 APE M+N Y++ VD++S G ++ E++ Sbjct: 193 MAPE-MINGRSYDEKVDVFSFGIVLCEII 220 >3VN9-A nrPDB Length = 340 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 80/301 (26%), Positives = 132/301 (43%), Gaps = 48/301 (15%) Query: 23 RYQNLSPV---GSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 + +L P+ G GAYG V +G +AVK++ ++ ++++ R L L Sbjct: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI----RATVNSQEQKRLLMDLDISM 104 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNN-----IVKCQKLTDDHVQFLIYQI 134 F A E DV++ LM L+ I K Q + +D + + I Sbjct: 105 RTVDCPFTVTFYGALFRE--GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 Query: 135 LRGLKYIHSA-DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV--ATRWYRAP 191 ++ L+++HS +IHRD+KPSN+ +N ++K+ DFG++ + D + + + Y AP Sbjct: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAP 222 Query: 192 EIM---LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 E + LN Y+ DIWS+G M EL R FP GTP +L + Sbjct: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSW-----------GTPFQQLKQ 269 Query: 249 KISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 + S Q+P F+ F VD + L +S +R T + + H +F Sbjct: 270 VVEEPSP--------QLPADKFSAEF-------VDFTSQCLKKNSKERPTYPELMQHPFF 314 Query: 309 A 309 Sbjct: 315 T 315 >4B8L-A nrPDB Length = 286 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 55/214 (25%), Positives = 95/214 (44%), Gaps = 15/214 (7%) Query: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSRP---FQSIIHAKRTYRELRLLKHMKHENVIG 85 P+G G +G+V A + + +A+K L + + + H R RE+ + H++H N++ Sbjct: 22 PLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLR--REIEIQSHLRHPNILR 79 Query: 86 LLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS 143 + + F + +YL+ G + K + + + ++ L Y H Sbjct: 80 MYNYF------HDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCHE 133 Query: 144 ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-EMTGYVATRWYRAPEIMLNWMHYNQ 202 +IHRD+KP NL + ELKI DFG + H T Y PE++ H ++ Sbjct: 134 RKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTH-DE 192 Query: 203 TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 VD+W G + E L G F H + + I+ Sbjct: 193 KVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIV 226 >2JD5-A nrPDB Length = 373 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 88/332 (26%), Positives = 145/332 (43%), Gaps = 60/332 (18%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRE-----LRLLKH 77 RY + +G G + +V A D VA+K I+ + Y E ++LL+ Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMK--------IVRGDKVYTEAAEDEIKLLQR 71 Query: 78 MK-----HENVIGLLDVFTPARSLEEFND-------VYLVTHLMGADLNNIVKC---QKL 122 + E+ +G + + L+ FN V +V ++G +L ++K + + Sbjct: 72 VNDADNTKEDSMGANHIL---KLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGI 128 Query: 123 TDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNLAVN------EDCELKILDFGLARHT 175 +V+ + Q+L GL Y+H IIH D+KP N+ + ++KI D G A Sbjct: 129 PLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWY 188 Query: 176 DDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLF-PGTDHI----- 229 D+ T + TR YR+PE++L + DIWS C++ EL+TG LF P H Sbjct: 189 DEHYTNSIQTREYRSPEVLLG-APWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDD 247 Query: 230 DQLKLILRLVGTPGAELLKKISSESARNYIQS---LTQMPKMNF---ANVFIGANPLA-- 281 D + I+ L+G + LL+ + + R + S L + K+ F +V + Sbjct: 248 DHIAQIIELLGELPSYLLR--NGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKD 305 Query: 282 -----VDLLEKMLVLDSDKRITAAQALAHAYF 308 D L ML LD KR A + H + Sbjct: 306 EAKEISDFLSPMLQLDPRKRADAGGLVNHPWL 337 >6GQK-A nrPDB Length = 328 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 65/239 (27%), Positives = 105/239 (43%), Gaps = 39/239 (16%) Query: 18 WEVP-ERYQNLSPVGSGAYGSVCAA-----FDTKTGLRVAVKKLSRPFQSIIHAKRTYRE 71 WE P R +G+GA+G V A + + VAVK L +P + E Sbjct: 36 WEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKML-KPSAHSTEREALMSE 94 Query: 72 LRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK--------- 121 L++L ++ HEN++ LL T + + + DL N ++ ++ Sbjct: 95 LKVLSYLGNHENIVNLLGACTHGGPT-----LVITEYCCYGDLLNFLRRKRDEFVPYKVA 149 Query: 122 --------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR 173 LT +H+ YQ+ +G+ ++ S + IHRDL N+ + KI DFGLAR Sbjct: 150 PEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLAR 209 Query: 174 HTD------DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPG 225 D+ + +W APE + N + Y D+WS G + EL + G + +PG Sbjct: 210 DIKNDSNYVDKGNARLPVKW-MAPESIFNSV-YTFESDVWSYGIFLWELFSLGSSPYPG 266 >3TAC-A nrPDB Length = 361 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 85/305 (27%), Positives = 134/305 (43%), Gaps = 56/305 (18%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKL------SRPFQSIIHAKRTYRELRLLKH 77 Y+ +G G + V + +TG + AVK + S P S KR E + Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKR---EASICHM 84 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLN-NIVKCQK----LTDDHVQFLI 131 +KH +++ LL+ ++ L Y+V M GADL IVK ++ + Sbjct: 85 LKHPHIVELLETYSSDGML------YMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYM 138 Query: 132 YQILRGLKYIHSADIIHRDLKPSN--LAVNED-CELKILDFGLARHTDDE---MTGYVAT 185 QIL L+Y H +IIHRD+KP LA E+ +K+ FG+A + G V T Sbjct: 139 RQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGT 198 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 + APE+ + Y + VD+W G I+ LL+G F GT Sbjct: 199 PHFMAPEV-VKREPYGKPVDVWGCGVILFILLSGCLPFYGTKE----------------R 241 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAH 305 L + I I+ +M ++++ + A DL+ +ML+LD +RIT +AL H Sbjct: 242 LFEGI--------IKGKYKMNPRQWSHI----SESAKDLVRRMLMLDPAERITVYEALNH 289 Query: 306 AYFAQ 310 + + Sbjct: 290 PWLKE 294 >3FME-A nrPDB Length = 290 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 80/301 (26%), Positives = 133/301 (44%), Gaps = 48/301 (15%) Query: 23 RYQNLSPV---GSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 + +L P+ G GAYG V +G +AVK++ ++ ++++ R L L Sbjct: 5 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI----RATVNSQEQKRLLMDLDISM 60 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNN-----IVKCQKLTDDHVQFLIYQI 134 F A E DV++ LM L+ I K Q + +D + + I Sbjct: 61 RTVDCPFTVTFYGALFRE--GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 118 Query: 135 LRGLKYIHSA-DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV--ATRWYRAP 191 ++ L+++HS +IHRD+KPSN+ +N ++K+ DFG++ + D++ + + Y AP Sbjct: 119 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAP 178 Query: 192 EIM---LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 E + LN Y+ DIWS+G M EL R FP GTP +L + Sbjct: 179 ERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSW-----------GTPFQQLKQ 225 Query: 249 KISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 + S Q+P F+ F VD + L +S +R T + + H +F Sbjct: 226 VVEEPSP--------QLPADKFSAEF-------VDFTSQCLKKNSKERPTYPELMQHPFF 270 Query: 309 A 309 Sbjct: 271 T 271 >4FZF-B nrPDB Length = 283 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 50/201 (24%), Positives = 95/201 (47%), Gaps = 10/201 (4%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E + L +G G++G V D +T VA+K + ++ + +E+ +L Sbjct: 8 ELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLE-EAEDEIEDIQQEITVLSQCDSS 66 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 V + L ++ +L G ++++ + + ++ +IL+GL Y+ Sbjct: 67 YVTKYYGSYLKGSKL-----WIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 121 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD---EMTGYVATRWYRAPEIMLNWM 198 HS IHRD+K +N+ ++E ++K+ FG+A D + +V T ++ APE+ + Sbjct: 122 HSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEV-IQQS 180 Query: 199 HYNQTVDIWSVGCIMAELLTG 219 Y+ DIWS+G EL G Sbjct: 181 AYDSKADIWSLGITAIELAKG 201 >5HI2-A nrPDB Length = 283 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 69/237 (29%), Positives = 122/237 (51%), Gaps = 35/237 (14%) Query: 18 WEVPERYQNLSP-VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 WE+P+ + +GSG++G+V + K VAVK L+ P Q + A + E+ +L+ Sbjct: 15 WEIPDGQITVGQRIGSGSFGTV---YKGKWHGDVAVKMLT-PQQ--LQAFKN--EVGVLR 66 Query: 77 HMKHENVIGLLDVFTP---ARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQ 133 +H N++ + T A + L HL ++ + +KL D + Q Sbjct: 67 KTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETK--FEMKKLID-----IARQ 119 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA--------RHTDDEMTGYVAT 185 RG+ Y+H+ IIHRDLK +N+ ++ED +KI DFGLA H ++++G + Sbjct: 120 TARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSIL- 178 Query: 186 RWYRAPEI--MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240 + APE+ M + Y+ D+++ G ++ EL+TG+ + ++ DQ I+ +VG Sbjct: 179 --WMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ---IIEMVG 230 >4WUA-A nrPDB Length = 401 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 98/365 (26%), Positives = 153/365 (41%), Gaps = 86/365 (23%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRT-YRELRLLKHMKH- 80 RY + +G G + +V ++D + VA+K + +S H T E+RLLK +++ Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVV----KSAEHYTETALDEIRLLKSVRNS 97 Query: 81 -------ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKC--QKLTDDHVQFL 130 E V+ LLD F S + +V ++G L I+K Q L V+ + Sbjct: 98 DPNDPNREMVVQLLDDFK--ISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKI 155 Query: 131 IYQILRGLKYIHS-ADIIHRDLKPSN--LAVNED-------------------------- 161 I Q+L+GL Y+H+ IIH D+KP N L+VNE Sbjct: 156 IQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVS 215 Query: 162 ---------------------CELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHY 200 ++KI D G A T + TR YR+ E+++ Y Sbjct: 216 TAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIG-SGY 274 Query: 201 NQTVDIWSVGCIMAELLTGRTLF---PGTDHI---DQLKLILRLVGTPGAELL--KKISS 252 N DIWS C+ EL TG LF G ++ D + LI+ L+G +L+ K S Sbjct: 275 NTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSK 334 Query: 253 E--SARNYIQSLTQMPKMNFANVFIGANPLA-------VDLLEKMLVLDSDKRITAAQAL 303 E + + ++ +T++ V + + D L ML L +KR TAA+ L Sbjct: 335 EFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECL 394 Query: 304 AHAYF 308 H + Sbjct: 395 RHPWL 399 >5DBX-A nrPDB Length = 328 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 97/208 (46%), Gaps = 25/208 (12%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +GSGA V AA RVA+K+++ + +E++ + H NV+ Sbjct: 19 IGSGATAVVQAALCKPRQERVAIKRINLE-KCQTSMDELLKEIQAMSQCSHPNVVTYYTS 77 Query: 90 FTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDH---------VQFLIYQILRGLK 139 F ++++LV L+ G + +I+K +H + ++ ++L GL Sbjct: 78 FVVK------DELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLD 131 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMT------GYVATRWYRAP 191 Y+H IHRDLK N+ + ED ++I DFG++ T ++T +V T + AP Sbjct: 132 YLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWMAP 191 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTG 219 E+M Y+ D+WS G EL TG Sbjct: 192 EVMEQVRGYDFKADMWSFGITAIELATG 219 >3NYO-A nrPDB Length = 576 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 68/244 (27%), Positives = 113/244 (46%), Gaps = 14/244 (5%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR-TYRELRLLKHMKHENVIGLLD 88 +G G +G VCA TG A KKL + + E ++L+ + V+ L Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL-- 249 Query: 89 VFTPARSLEEFNDVYLVTHLM-GADLNNIV---KCQKLTDDHVQFLIYQILRGLKYIHSA 144 A + E + + LV LM G DL + + F +I GL+ +H Sbjct: 250 ----AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 Query: 145 DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT--GYVATRWYRAPEIMLNWMHYNQ 202 I++RDLKP N+ +++ ++I D GLA H + T G V T Y APE++ N Y Sbjct: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN-ERYTF 364 Query: 203 TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSL 262 + D W++GC++ E++ G++ F + + + RLV E ++ S ++ Q L Sbjct: 365 SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLL 424 Query: 263 TQMP 266 + P Sbjct: 425 CKDP 428 >6ED6-A nrPDB Length = 415 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 62/214 (28%), Positives = 96/214 (44%), Gaps = 21/214 (9%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTY--RELRLLKHMK 79 E Y + +G GA+G V K +V KL F+ I + + E ++ Sbjct: 88 EDYDVVKVIGRGAFGEV-QLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFAN 146 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQILRGL 138 V+ L F R L Y+V M G DL N++ + + +F +++ L Sbjct: 147 SPWVVQLFYAFQDDRYL------YMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLAL 200 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY------VATRWYRAPE 192 IHS +IHRD+KP N+ +++ LK+ DFG D+ TG V T Y +PE Sbjct: 201 DAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDE--TGMVHCDTAVGTPDYISPE 258 Query: 193 IMLNW---MHYNQTVDIWSVGCIMAELLTGRTLF 223 ++ + Y + D WSVG + E+L G T F Sbjct: 259 VLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPF 292 >5L6P-A nrPDB Length = 298 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 97/205 (47%), Gaps = 26/205 (12%) Query: 30 VGSGAYGSVCAAFDTKTGLR---VAVKKLSRPFQSIIHAKRTY-RELRLLKHMKHENVIG 85 +G+G +G VC + G R VA+K L + +R + E ++ H N+I Sbjct: 27 IGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTE--RQRRDFLSEASIMGQFDHPNIIR 84 Query: 86 LLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ--KLTDDHVQFLIYQILRGLKYIH 142 L V T +R V ++T M L++ ++ + T + ++ I G+KY+ Sbjct: 85 LEGVVTKSRP------VMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLS 138 Query: 143 SADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---------MTGYVATRWYRAPEI 193 + +HRDL N+ VN + K+ DFGL+R +D+ + G + RW APE Sbjct: 139 EMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWT-APE- 196 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLT 218 + + + D+WS G +M E+++ Sbjct: 197 AIAYRKFTSASDVWSYGIVMWEVMS 221 >4GS6-A nrPDB Length = 315 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 65/203 (32%), Positives = 92/203 (45%), Gaps = 24/203 (11%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 VG GA+G VC A VA+K++ +S K ELR L + H N++ L Sbjct: 17 VGRGAFGVVCKA--KWRAKDVAIKQI----ESESERKAFIVELRQLSRVNHPNIVKLYGA 70 Query: 90 FTPARSLEEFNDVYLVT-HLMGADLNNIVKCQK----LTDDHVQFLIYQILRGLKYIHSA 144 N V LV + G L N++ + T H Q +G+ Y+HS Sbjct: 71 C--------LNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 122 Query: 145 D---IIHRDLKPSNLA-VNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHY 200 +IHRDLKP NL V LKI DFG A MT + + APE+ +Y Sbjct: 123 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEG-SNY 181 Query: 201 NQTVDIWSVGCIMAELLTGRTLF 223 ++ D++S G I+ E++T R F Sbjct: 182 SEKCDVFSWGIILWEVITRRKPF 204 >1VZO-A nrPDB Length = 355 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 75/294 (25%), Positives = 131/294 (44%), Gaps = 50/294 (17%) Query: 22 ERYQNLSPVGSGAYGSV-----CAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 E ++ L +G+GAYG V + DT + V K + Q + T E ++L+ Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 77 HMKHENVIGLLDVFTPARS-----LEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLI 131 H++ + L + L+ N L THL + ++ T+ VQ + Sbjct: 114 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLS--------QRERFTEHEVQIYV 165 Query: 132 YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGY--VATRW 187 +I+ L+++H II+RD+K N+ ++ + + + DFGL++ D+ Y T Sbjct: 166 GEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIE 225 Query: 188 YRAPEIMLNW-MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 Y AP+I+ +++ VD WS+G +M ELLTG + F T E Sbjct: 226 YMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF-----------------TVDGE- 267 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300 K +E +R ++S P+ A LA DL++++L+ D KR+ Sbjct: 268 -KNSQAEISRRILKSEPPYPQEMSA--------LAKDLIQRLLMKDPKKRLGCG 312 >3PLS-A nrPDB Length = 298 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 57/219 (26%), Positives = 97/219 (44%), Gaps = 24/219 (10%) Query: 30 VGSGAYGSVCAAF---DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGL 86 +G G +G V + ++ A+K LSR + + RE L++ + H NV+ L Sbjct: 29 IGKGHFGVVYHGEYIDQAQNRIQCAIKSLSR-ITEMQQVEAFLREGLLMRGLNHPNVLAL 87 Query: 87 LDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK---LTDDHVQFLIYQILRGLKYIHS 143 + + P L L+ ++ DL ++ + D + F + Q+ RG++Y+ Sbjct: 88 IGIMLPPEGLPHV----LLPYMCHGDLLQFIRSPQRNPTVKDLISFGL-QVARGMEYLAE 142 Query: 144 ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWM----- 198 +HRDL N ++E +K+ DFGLAR D Y + + +R + + W Sbjct: 143 QKFVHRDLAARNCMLDESFTVKVADFGLARDILDR--EYYSVQQHRHARLPVKWTALESL 200 Query: 199 ---HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKL 234 + D+WS G ++ ELLT P HID L Sbjct: 201 QTYRFTTKSDVWSFGVLLWELLTRGA--PPYRHIDPFDL 237 >5O2C-A nrPDB Length = 380 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 73/287 (25%), Positives = 132/287 (45%), Gaps = 38/287 (13%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G GA+ +V DT+T + VA +L + +R E +LK ++H N++ D Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 92 Query: 90 FTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHV-QFLIYQILRGLKYIHSAD-- 145 + L+ + LVT LM L +K K+ V + QIL+GL+++H+ Sbjct: 93 WESI--LKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 150 Query: 146 IIHRDLKPSNLAVNEDC-ELKILDFGLARHTDDEMT-GYVATRWYRAPEIMLNWMHYNQT 203 IIHRDLK N+ + +KI D GLA + T + APE+ HY+++ Sbjct: 151 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEE--HYDES 208 Query: 204 VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLT 263 VD+++ G M E+ T +P ++ + A++ +K++S Sbjct: 209 VDVYAFGMCMLEMATSE--YPYSECQN------------AAQIYRKVTS----------- 243 Query: 264 QMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 + +F V +P +++E + + +R++ L HA+FA+ Sbjct: 244 GIKPASFNKV---TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 287 >4M7I-A nrPDB Length = 299 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 55/220 (25%), Positives = 100/220 (45%), Gaps = 28/220 (12%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 ++ + +G G +G V A + A+K++ P + + K RE++ L ++H + Sbjct: 7 FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREK-VMREVKALAKLEHPGI 65 Query: 84 IGLLDVFTPARSLEEFN----DVYLVTHLMGADLNNIV-----KC--QKLTDDHVQFLIY 132 + + + + E+ VYL + N+ +C ++ + Sbjct: 66 VRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFL 125 Query: 133 QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------------- 178 QI ++++HS ++HRDLKPSN+ D +K+ DFGL D + Sbjct: 126 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYA 185 Query: 179 -MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 TG V T+ Y +PE ++ Y+ VDI+S+G I+ ELL Sbjct: 186 RHTGQVGTKLYMSPE-QIHGNSYSHKVDIFSLGLILFELL 224 >1JPA-A nrPDB Length = 312 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 96/205 (46%), Gaps = 26/205 (12%) Query: 30 VGSGAYGSVCAAFDTKTGLR---VAVKKLSRPFQSIIHAKRTY-RELRLLKHMKHENVIG 85 +G+G +G VC+ G R VA+K L + +R + E ++ H NVI Sbjct: 41 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTE--KQRRDFLSEASIMGQFDHPNVIH 98 Query: 86 LLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ--KLTDDHVQFLIYQILRGLKYIH 142 L V T + V ++T M L++ ++ + T + ++ I G+KY+ Sbjct: 99 LEGVVTKS------TPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLA 152 Query: 143 SADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---------MTGYVATRWYRAPEI 193 + +HRDL N+ VN + K+ DFGL+R +D+ + G + RW APE Sbjct: 153 DMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW-TAPE- 210 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLT 218 + + + D+WS G +M E+++ Sbjct: 211 AIQYRKFTSASDVWSYGIVMWEVMS 235 >5GRN-A nrPDB Length = 356 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 72/247 (29%), Positives = 118/247 (47%), Gaps = 45/247 (18%) Query: 18 WEVPERYQNLSPV-GSGAYGSVCAAFDTKTGL-------RVAVKKLSRPFQSIIHAKRTY 69 WE P L V GSGA+G V T GL +VAVK L +P + Sbjct: 41 WEFPRDGLVLGRVLGSGAFGKVVEG--TAYGLSRSQPVMKVAVKML-KPTARSSEKQALM 97 Query: 70 RELRLLKHMK-HENVIGLLDVFT---PARSLEEF------------NDVYLVTHLMGADL 113 EL+++ H+ H N++ LL T P + E+ N ++H + L Sbjct: 98 SELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSML 157 Query: 114 NNIVKCQKLTDDHVQFLI--------YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELK 165 ++ VK L+DD+ + L YQ+ RG++++ S + +HRDL N+ + + +K Sbjct: 158 DSEVK-NLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVK 216 Query: 166 ILDFGLAR---HTDD---EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT- 218 I DFGLAR H + + + ++ +W APE + + + Y D+WS G ++ E+ + Sbjct: 217 ICDFGLARDIMHDSNYVSKGSTFLPVKW-MAPESIFDNL-YTTLSDVWSYGILLWEIFSL 274 Query: 219 GRTLFPG 225 G T +PG Sbjct: 275 GGTPYPG 281 >5O2B-A nrPDB Length = 285 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 73/287 (25%), Positives = 132/287 (45%), Gaps = 38/287 (13%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G GA+ +V DT+T + VA +L + +R E +LK ++H N++ D Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 83 Query: 90 FTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHV-QFLIYQILRGLKYIHSAD-- 145 + L+ + LVT LM L +K K+ V + QIL+GL+++H+ Sbjct: 84 WESI--LKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 141 Query: 146 IIHRDLKPSNLAV-NEDCELKILDFGLARHTDDEMT-GYVATRWYRAPEIMLNWMHYNQT 203 IIHRDLK N+ + +KI D GLA + T + APE+ HY+++ Sbjct: 142 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEE--HYDES 199 Query: 204 VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLT 263 VD+++ G M E+ T +P ++ + A++ +K++S Sbjct: 200 VDVYAFGMCMLEMATSE--YPYSECQN------------AAQIYRKVTS----------- 234 Query: 264 QMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 + +F V +P +++E + + +R++ L HA+FA+ Sbjct: 235 GIKPASFNKV---TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 >2A1A-B nrPDB Length = 284 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 58/210 (27%), Positives = 101/210 (48%), Gaps = 23/210 (10%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 ++ + +GSG +G V A G +K++ + ++ RE++ L + H N+ Sbjct: 13 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVK------YNNEKAEREVKALAKLDHVNI 66 Query: 84 I---GLLDVF-----TPARSLEEFNDVYLVTHLMGADLNNI------VKCQKLTDDHVQF 129 + G D F T +++ L + D + + +KL Sbjct: 67 VHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALE 126 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGL--ARHTDDEMTGYVATRW 187 L QI +G+ YIHS +I+RDLKPSN+ + + ++KI DFGL + D + T T Sbjct: 127 LFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLR 186 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 Y +PE ++ Y + VD++++G I+AELL Sbjct: 187 YMSPE-QISSQDYGKEVDLYALGLILAELL 215 >5HIE-A nrPDB Length = 302 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 65/231 (28%), Positives = 118/231 (51%), Gaps = 36/231 (15%) Query: 18 WEVPERYQNLSP-VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 WE+P+ + +GSG++G+V + K VAVK L+ P Q + A + E+ +L+ Sbjct: 31 WEIPDGQITVGQRIGSGSFGTV---YKGKWHGDVAVKMLT-PQQ--LQAFKN--EVGVLR 82 Query: 77 HMKHENVIGLLDVFTPAR-----SLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLI 131 +H N++ + T + E + +Y H++ I KL D + Sbjct: 83 KTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMI----KLID-----IA 133 Query: 132 YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA--------RHTDDEMTGYV 183 Q +G+ Y+H+ IIHRDLK +N+ ++ED +KI DFGLA H ++++G + Sbjct: 134 RQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSI 193 Query: 184 ATRWYRAPEI--MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQL 232 + APE+ M + Y+ D+++ G ++ EL+TG+ + ++ DQ+ Sbjct: 194 L---WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQI 241 >4E93-A nrPDB Length = 377 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 59/205 (28%), Positives = 94/205 (45%), Gaps = 19/205 (9%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G +G V + VAVK + AK +E R+LK H N++ L+ V Sbjct: 122 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK-FLQEARILKQYSHPNIVRLIGV 180 Query: 90 FTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ--KLTDDHVQFLIYQILRGLKYIHSADI 146 T + +Y+V L+ G D ++ + +L + ++ G++Y+ S Sbjct: 181 CT------QKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCC 234 Query: 147 IHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG------YVATRWYRAPEIMLNWMHY 200 IHRDL N V E LKI DFG++R D + V +W APE LN+ Y Sbjct: 235 IHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW-TAPE-ALNYGRY 292 Query: 201 NQTVDIWSVGCIMAELLT-GRTLFP 224 + D+WS G ++ E + G + +P Sbjct: 293 SSESDVWSFGILLWETFSLGASPYP 317 >3TXO-A nrPDB Length = 353 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/224 (27%), Positives = 105/224 (46%), Gaps = 18/224 (8%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH---AKRTYRELRLLKHM 78 + ++ + +G G++G V A +TG AVK L + I+ + T E R+L Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKK--DVILQDDDVECTMTEKRILSLA 80 Query: 79 K-HENVIGLLDVF-TPARSLEEFNDVYLVTHLMGADLN-NIVKCQKLTDDHVQFLIYQIL 135 + H + L F TP R +++ + G DL +I K ++ + +F +I+ Sbjct: 81 RNHPFLTQLFCCFQTPDRLF------FVMEFVNGGDLMFHIQKSRRFDEARARFYAAEII 134 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH---TDDEMTGYVATRWYRAPE 192 L ++H II+RDLK N+ ++ + K+ DFG+ + + T Y APE Sbjct: 135 SALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPE 194 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 I L M Y VD W++G ++ E+L G F + D + IL Sbjct: 195 I-LQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAIL 237 >6CTH-A nrPDB Length = 309 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 105/212 (49%), Gaps = 19/212 (8%) Query: 19 EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 +V + + +G G +GSV F + +AVKK+SR + I K E++++ + Sbjct: 12 KVTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGI--KEYASEVKIISRL 69 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQIL- 135 +H+N++ L+ E ++ LV M G+ ++I K + L V++ I + L Sbjct: 70 RHKNLVKLIGW------CHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLA 123 Query: 136 RGLKYIHSAD---IIHRDLKPSNLAVNEDCELKILDFGLARHTDD----EMTGYVATRWY 188 L Y+H ++HRD+K SN+ ++ K+ DFGLAR D + T T Y Sbjct: 124 SALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGY 183 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLTGR 220 APE + + ++ D++S G + E+ +GR Sbjct: 184 MAPECLSSGKASKES-DVYSFGVVALEIASGR 214 >3PPZ-A nrPDB Length = 309 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 58/203 (28%), Positives = 101/203 (49%), Gaps = 27/203 (13%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRT---YRELRLLKHMKHENVIGL 86 +G+G++G+V A G VAVK L + HA+R RE+ ++K ++H N++ Sbjct: 45 IGAGSFGTVHRA--EWHGSDVAVKIL---MEQDFHAERVNEFLREVAIMKRLRHPNIVLF 99 Query: 87 LDVFTPARSLEEFND------VYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKY 140 + T +L + +Y + H GA ++L + + Y + +G+ Y Sbjct: 100 MGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAR-------EQLDERRRLSMAYDVAKGMNY 152 Query: 141 IHSAD--IIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTGYVATRWYRAPEIML 195 +H+ + I+HRDLK NL V++ +K+ DFGL+R T T + APE++ Sbjct: 153 LHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLR 212 Query: 196 NWMHYNQTVDIWSVGCIMAELLT 218 + N+ D++S G I+ EL T Sbjct: 213 D-EPSNEKSDVYSFGVILWELAT 234 >4NEU-A nrPDB Length = 333 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 57/230 (24%), Positives = 103/230 (44%), Gaps = 26/230 (11%) Query: 32 SGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFT 91 SG +G V F GL + +K + + I H + E +++ ++H V+ LL V Sbjct: 34 SGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVI- 91 Query: 92 PARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQF-LIYQILRGLKYIHSADIIHRD 150 +EE ++ ++ +L +++K + T V+ +I +I+ G+ Y+H +IH+D Sbjct: 92 ----IEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKD 147 Query: 151 LKPSNLAVNEDCELKILDFGLA----------------RHTDDEMTGYVATRWYRAPEIM 194 LKP N+ V+ D +KI D GLA R D T +Y APE Sbjct: 148 LKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPE-H 206 Query: 195 LNWMHYNQT--VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 242 LN ++ T D++S ++ + + + QL + ++ P Sbjct: 207 LNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRP 256 >1TKI-A nrPDB Length = 321 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 71/301 (23%), Positives = 134/301 (44%), Gaps = 48/301 (15%) Query: 19 EVPERYQNLSPVGSGAYGSV--CAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 E+ E+Y +G G +G V C +K K+ Q ++ +E+ +L Sbjct: 2 ELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVK-----KEISILN 56 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ--KLTDDHVQFLIYQI 134 +H N++ L + F S+EE V + + G D+ + +L + + ++Q+ Sbjct: 57 IARHRNILHLHESF---ESMEEL--VMIFEFISGLDIFERINTSAFELNEREIVSYVHQV 111 Query: 135 LRGLKYIHSADIIHRDLKPSNL--AVNEDCELKILDFGLARH---TDDEMTGYVATRWYR 189 L+++HS +I H D++P N+ +KI++FG AR D+ + A +Y Sbjct: 112 CEALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYY- 170 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 APE+ + + + D+WS+G ++ LL+G F + ++ I+ T E K+ Sbjct: 171 APEVHQHDV-VSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKE 229 Query: 250 ISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 IS E A+D ++++LV + R+TA++AL H + Sbjct: 230 ISIE---------------------------AMDFVDRLLVKERKSRMTASEALQHPWLK 262 Query: 310 Q 310 Q Sbjct: 263 Q 263 >3ALO-A nrPDB Length = 327 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 78/307 (25%), Positives = 128/307 (41%), Gaps = 49/307 (15%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E ++L +G GAYGSV +G +AVK++ +S + K + L L + Sbjct: 22 EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRI----RSTVDEKEQKQLLMDLDVVMRS 77 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK-CQKLTDD--------HVQFLIY 132 + + F A E D ++ LM + K + DD + Sbjct: 78 SDCPYIVQFYGALFRE--GDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATV 135 Query: 133 QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM--TGYVATRWYRA 190 + L LK + IIHRD+KPSN+ ++ +K+ DFG++ D + T R Y A Sbjct: 136 KALNHLK--ENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMA 193 Query: 191 PEIM---LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI-DQLKLILRLVGTPGAEL 246 PE + + Y+ D+WS+G + EL TGR +P + + DQL +++ G P Sbjct: 194 PERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK--GDP---- 247 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHA 306 ++S+ R + S +NF N+ L D KR + L H Sbjct: 248 -PQLSNSEEREFSPSF-----INFVNL--------------CLTKDESKRPKYKELLKHP 287 Query: 307 YFAQYHD 313 + Y + Sbjct: 288 FILMYEE 294 >5X5O-A nrPDB Length = 310 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 96/216 (44%), Gaps = 17/216 (7%) Query: 25 QNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVI 84 Q G G++GSV A VAVKKL + +E +L + H N+I Sbjct: 18 QFFENCGGGSFGSVYRAKWISQDKEVAVKKL----------LKIEKEAEILSVLSHRNII 67 Query: 85 GLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIH-- 142 V + + + L D N + +++ DH+ + +G+ Y+H Sbjct: 68 QFYGVILEPPNYGIVTEYASLGSLY--DYINSNRSEEMDMDHIMTWATDVAKGMHYLHME 125 Query: 143 -SADIIHRDLKPSNLAVNEDCELKILDFGLAR-HTDDEMTGYVATRWYRAPEIMLNWMHY 200 +IHRDLK N+ + D LKI DFG +R H V T + APE++ + + Sbjct: 126 APVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS-LPV 184 Query: 201 NQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 ++T D +S G ++ E+LT F G + + L++ Sbjct: 185 SETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVV 220 >4HVI-A nrPDB Length = 314 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 73/256 (28%), Positives = 122/256 (47%), Gaps = 43/256 (16%) Query: 14 NKTIWEVPERY-QNLSPVGSGAYGSV--CA--AFDTKTGLRVAVKKLSRPFQSIIHAKRT 68 + TI+E ER+ + +S +G G +GSV C TG VAVK+L S +R Sbjct: 3 DPTIFE--ERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ---HSGPDQQRD 57 Query: 69 Y-RELRLLKHMKHENVIGLLDV-FTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDH 126 + RE+++LK + + ++ V + P R ++ +L L + ++ + D Sbjct: 58 FQREIQILKALHSDFIVKYRGVSYGPGRQSLRL----VMEYLPSGCLRDFLQRHRARLDA 113 Query: 127 VQFLIY--QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVA 184 + L+Y QI +G++Y+ S +HRDL N+ V + +KI DFGLA+ + YV Sbjct: 114 SRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVV 173 Query: 185 TR-------WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 WY APE + + + Q+ D+WS G ++ EL T + D+ Sbjct: 174 REPGQSPIFWY-APESLSDNIFSRQS-DVWSFGVVLYELFT---------YCDK------ 216 Query: 238 LVGTPGAELLKKISSE 253 +P AE L+ + SE Sbjct: 217 -SCSPSAEFLRMMGSE 231 >5UUU-A nrPDB Length = 547 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 59/238 (24%), Positives = 115/238 (48%), Gaps = 7/238 (2%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G +G V TG A+K L + + + R++ + + Sbjct: 206 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 265 Query: 90 FTPARSLEEFNDVYLVTHLM-GADLN-NIVKCQKLTDDHVQFLIYQILRGLKYIHSADII 147 + A + + + LM G DL+ ++ + ++ ++F +I+ GL+++H+ ++ Sbjct: 266 MSYA--FHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVV 323 Query: 148 HRDLKPSNLAVNEDCELKILDFGLA-RHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDI 206 +RDLKP+N+ ++E ++I D GLA + + V T Y APE++ + Y+ + D Sbjct: 324 YRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADW 383 Query: 207 WSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQ 264 +S+GC++ +LL G + F D+ + I R+ T EL S E R+ ++ L Q Sbjct: 384 FSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTMAVELPDSFSPE-LRSLLEGLLQ 439 >5MJB-A nrPDB Length = 305 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 56/209 (26%), Positives = 92/209 (44%), Gaps = 34/209 (16%) Query: 30 VGSGAYGSVCAA---FDTKTGLRVAVKKLSRPFQSIIHAKRTY-RELRLLKHMKHENVIG 85 +G+G +G V K + VA+K L + +R + E ++ H N+I Sbjct: 34 IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSE--KQRRDFLSEASIMGQFDHRNIIR 91 Query: 86 LLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQ-------ILRGL 138 L V T +R V ++T M N L + QF + Q I G+ Sbjct: 92 LEGVVTKSRP------VMIITEFM----ENCALDSFLRQNDGQFTVIQLVGMLRGIAAGM 141 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---------MTGYVATRWYR 189 KY+ + +HRDL N+ VN + K+ DFGL+R+ D+ + G + RW Sbjct: 142 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRW-T 200 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLT 218 APE + + + D+WS G +M E+++ Sbjct: 201 APE-AIAYRKFTSASDVWSYGIVMWEVMS 228 >4RC3-A nrPDB Length = 289 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 57/230 (24%), Positives = 107/230 (46%), Gaps = 25/230 (10%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP----FQSIIHAKRTYRELRLLKHM 78 +YQ +GSG +GSV + L VA+K + + + + + R E+ LLK + Sbjct: 13 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 72 Query: 79 KH--ENVIGLLDVFTPARSL-------EEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQF 129 VI LLD F S E D++ GA L ++ + Sbjct: 73 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA----------LQEELARS 122 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNED-CELKILDFGLARHTDDEM-TGYVATRW 187 +Q+L +++ H+ ++HRD+K N+ ++ + ELK++DFG D + T + TR Sbjct: 123 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV 182 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 Y PE + ++ ++ +WS+G ++ +++ G F + I + ++ R Sbjct: 183 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR 232 >5TUR-A nrPDB Length = 404 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 57/230 (24%), Positives = 106/230 (46%), Gaps = 25/230 (10%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP----FQSIIHAKRTYRELRLLKHM 78 +YQ +GSG +GSV + L VA+K + + + + + R E+ LLK + Sbjct: 128 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 187 Query: 79 KH--ENVIGLLDVFTPARSL-------EEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQF 129 VI LLD F S E D++ GA L ++ + Sbjct: 188 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA----------LQEELARS 237 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLARHTDDEM-TGYVATRW 187 +Q+L +++ H+ ++HRD+K N+ ++ ELK++DFG D + T + TR Sbjct: 238 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV 297 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 Y PE + ++ ++ +WS+G ++ +++ G F + I + ++ R Sbjct: 298 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR 347 >3PVW-A nrPDB Length = 695 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 59/238 (24%), Positives = 115/238 (48%), Gaps = 7/238 (2%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G +G V TG A+K L + + + R++ + + Sbjct: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 Query: 90 FTPARSLEEFNDVYLVTHLM-GADLN-NIVKCQKLTDDHVQFLIYQILRGLKYIHSADII 147 + A + + + LM G DL+ ++ + ++ ++F +I+ GL+++H+ ++ Sbjct: 257 MSYA--FHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVV 314 Query: 148 HRDLKPSNLAVNEDCELKILDFGLA-RHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDI 206 +RDLKP+N+ ++E ++I D GLA + + V T Y APE++ + Y+ + D Sbjct: 315 YRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADW 374 Query: 207 WSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQ 264 +S+GC++ +LL G + F D+ + I R+ T EL S E R+ ++ L Q Sbjct: 375 FSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTMAVELPDSFSPE-LRSLLEGLLQ 430 >3BGP-A nrPDB Length = 333 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 57/230 (24%), Positives = 107/230 (46%), Gaps = 25/230 (10%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP----FQSIIHAKRTYRELRLLKHM 78 +YQ +GSG +GSV + L VA+K + + + + + R E+ LLK + Sbjct: 57 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 116 Query: 79 KH--ENVIGLLDVFTPARSL-------EEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQF 129 VI LLD F S E D++ GA L ++ + Sbjct: 117 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA----------LQEELARS 166 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNED-CELKILDFGLARHTDDEM-TGYVATRW 187 +Q+L +++ H+ ++HRD+K N+ ++ + ELK++DFG D + T + TR Sbjct: 167 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV 226 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 Y PE + ++ ++ +WS+G ++ +++ G F + I + ++ R Sbjct: 227 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR 276 >6DBN-A nrPDB Length = 316 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 62/203 (30%), Positives = 96/203 (47%), Gaps = 21/203 (10%) Query: 30 VGSGAYGSV-CAAFDTK---TGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIG 85 +G G +G V +D + TG +VAVK L +P H +E+ +L+++ HEN++ Sbjct: 43 LGEGHFGKVELCRYDPEGDNTGEQVAVKSL-KPESGGNHIADLKKEIEILRNLYHENIVK 101 Query: 86 LLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIY--QILRGLKYIH 142 + T N + L+ + L + K + Q L Y QI +G+ Y+ Sbjct: 102 YKGICTEDGG----NGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLG 157 Query: 143 SADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVATR-----WYRAPEIML 195 S +HRDL N+ V + ++KI DFGL + TD E R WY APE ++ Sbjct: 158 SRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWY-APECLM 216 Query: 196 NWMHYNQTVDIWSVGCIMAELLT 218 Y + D+WS G + ELLT Sbjct: 217 QSKFYIAS-DVWSFGVTLHELLT 238 >3ORP-A nrPDB Length = 311 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 60/216 (27%), Positives = 97/216 (44%), Gaps = 18/216 (8%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSIIHAKRTYRELRLLKHMKH 80 +RY+ +G G V A D + VAVK L + R RE + + H Sbjct: 12 DRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNH 71 Query: 81 ENVIGLLDVF---TPARSLEEFNDVYLVTHLM-GADLNNIVKCQK-LTDDHVQFLIYQIL 135 ++ + D TPA L Y+V + G L +IV + +T +I Sbjct: 72 PAIVAVYDTGEAETPAGPLP-----YIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADAC 126 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD------EMTGYVATRWYR 189 + L + H IIHRD+KP+N+ ++ +K++DFG+AR D + + T Y Sbjct: 127 QALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYL 186 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPG 225 +PE + D++S+GC++ E+LTG F G Sbjct: 187 SPE-QARGDSVDARSDVYSLGCVLYEVLTGEPPFTG 221 >4RA4-A nrPDB Length = 355 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 43/138 (31%), Positives = 76/138 (55%), Gaps = 5/138 (3%) Query: 103 YLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNED 161 +++ ++ G DL +I + K + F +I GL ++H II+RDLK N+ ++ + Sbjct: 98 FVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSE 157 Query: 162 CELKILDFGLAR-HTDDEMT--GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 +KI DFG+ + H D +T + T Y APEI + + Y ++VD W+ G ++ E+L Sbjct: 158 GHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEI-IAYQPYGKSVDWWAYGVLLYEMLA 216 Query: 219 GRTLFPGTDHIDQLKLIL 236 G+ F G D + + I+ Sbjct: 217 GQPPFDGEDEDELFQSIM 234 >5X02-A nrPDB Length = 347 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 67/248 (27%), Positives = 110/248 (44%), Gaps = 50/248 (20%) Query: 18 WEVPERYQNLSPV-GSGAYGSVCAAFD---TKTG--LRVAVKKLSRPFQSIIHAKRTYRE 71 WE P V GSGA+G V A +KTG ++VAVK L S + E Sbjct: 43 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS-EREALMSE 101 Query: 72 LRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLV-THLMGADLNNIVKC--QKLTDDHV 127 L+++ + HEN++ LL T + +YL+ + DL N ++ +K ++D + Sbjct: 102 LKMMTQLGSHENIVNLLGACTLS------GPIYLIFEYCCYGDLLNYLRSKREKFSEDEI 155 Query: 128 QF----------------------LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELK 165 ++ YQ+ +G++++ +HRDL N+ V +K Sbjct: 156 EYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVK 215 Query: 166 ILDFGLARHTDDEMTGYVA-------TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 I DFGLAR + + YV +W APE + + Y D+WS G ++ E+ + Sbjct: 216 ICDFGLARDIMSD-SNYVVRGNARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFS 272 Query: 219 -GRTLFPG 225 G +PG Sbjct: 273 LGVNPYPG 280 >6HXF-B nrPDB Length = 302 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 58/240 (24%), Positives = 114/240 (47%), Gaps = 25/240 (10%) Query: 17 IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 +WE+ + +G GA+G V A + +TG A K + +S + E+ +L Sbjct: 20 VWEI------VGELGDGAFGKVYKAKNKETGALAAAKVIET--KSEEELEDYIVEIEILA 71 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC--QKLTDDHVQFLIYQI 134 H ++ LL + L ++ G ++ I+ + LT+ +Q + Q+ Sbjct: 72 TCDHPYIVKLLGAYYHDGKL-----WIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQM 126 Query: 135 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTGYVATRWYRAP 191 L L ++HS IIHRDLK N+ + + ++++ DFG++ T + ++ T ++ AP Sbjct: 127 LEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAP 186 Query: 192 E-IMLNWMH---YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247 E +M M Y+ DIWS+G + E+ + P ++ ++++L++ + LL Sbjct: 187 EVVMCETMKDTPYDYKADIWSLGITLIEM---AQIEPPHHELNPMRVLLKIAKSDPPTLL 243 >2R2P-A nrPDB Length = 295 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 55/203 (27%), Positives = 94/203 (46%), Gaps = 24/203 (11%) Query: 30 VGSGAYGSVCAA---FDTKTGLRVAVKKLSRPFQSIIHAKRTY-RELRLLKHMKHENVIG 85 +G+G +G VC+ K L VA+K L + +R + E ++ H N+I Sbjct: 30 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTE--KQRRDFLGEASIMGQFDHPNIIH 87 Query: 86 LLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ--KLTDDHVQFLIYQILRGLKYIH 142 L V T ++ V +VT M L+ +K + T + ++ I G+KY+ Sbjct: 88 LEGVVTKSKP------VMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLS 141 Query: 143 SADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYRAPEIML 195 +HRDL N+ +N + K+ DFGL+R +D+ G + RW APE + Sbjct: 142 DMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW-TAPE-AI 199 Query: 196 NWMHYNQTVDIWSVGCIMAELLT 218 + + D+WS G +M E+++ Sbjct: 200 AFRKFTSASDVWSYGIVMWEVVS 222 >2I0E-A nrPDB Length = 353 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 42/138 (30%), Positives = 75/138 (54%), Gaps = 5/138 (3%) Query: 103 YLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNED 161 +++ ++ G DL +I + + + H F +I GL ++ S II+RDLK N+ ++ + Sbjct: 98 FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 157 Query: 162 CELKILDFGLARHT--DDEMTG-YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 +KI DFG+ + D T + T Y APEI + + Y ++VD W+ G ++ E+L Sbjct: 158 GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI-IAYQPYGKSVDWWAFGVLLYEMLA 216 Query: 219 GRTLFPGTDHIDQLKLIL 236 G+ F G D + + I+ Sbjct: 217 GQAPFEGEDEDELFQSIM 234 >3UIU-A nrPDB Length = 306 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 62/232 (26%), Positives = 104/232 (44%), Gaps = 54/232 (23%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 ++ + +GSG +G V A G ++++ + ++ RE++ L + H N+ Sbjct: 14 FKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVK------YNNEKAEREVKALAKLDHVNI 67 Query: 84 I---GLLDVF-----TPARSLE------------------------EFNDVYLVTHLM-- 109 + G D F T SLE EF D + + Sbjct: 68 VHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK 127 Query: 110 --GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKIL 167 G L+ ++ + L QI +G+ YIHS +IHRDLKPSN+ + + ++KI Sbjct: 128 RRGEKLDKVLALE---------LFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIG 178 Query: 168 DFGL--ARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 DFGL + D + T T Y +PE ++ Y + VD++++G I+AELL Sbjct: 179 DFGLVTSLKNDGKRTRSKGTLRYMSPE-QISSQDYGKEVDLYALGLILAELL 229 >3PFQ-A nrPDB Length = 674 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 42/138 (30%), Positives = 75/138 (54%), Gaps = 5/138 (3%) Query: 103 YLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNED 161 +++ ++ G DL +I + + + H F +I GL ++ S II+RDLK N+ ++ + Sbjct: 419 FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 478 Query: 162 CELKILDFGLARHT--DDEMTG-YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 +KI DFG+ + D T + T Y APEI + + Y ++VD W+ G ++ E+L Sbjct: 479 GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI-IAYQPYGKSVDWWAFGVLLYEMLA 537 Query: 219 GRTLFPGTDHIDQLKLIL 236 G+ F G D + + I+ Sbjct: 538 GQAPFEGEDEDELFQSIM 555 >4XUF-A nrPDB Length = 297 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 67/249 (26%), Positives = 108/249 (43%), Gaps = 52/249 (20%) Query: 18 WEVPERYQNLSPV-GSGAYGSVCAAFD---TKTG--LRVAVKKLSRPFQSIIHAKRTYRE 71 WE P V GSGA+G V A +KTG ++VAVK L S + E Sbjct: 4 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS-EREALMSE 62 Query: 72 LRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLV-THLMGADLNNIVKC--QKLTDDHV 127 L+++ + HEN++ LL T + +YL+ + DL N ++ +K ++D + Sbjct: 63 LKMMTQLGSHENIVNLLGACTLS------GPIYLIFEYCCYGDLLNYLRSKREKFSEDEI 116 Query: 128 QF----------------------LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELK 165 ++ YQ+ +G++++ +HRDL N+ V +K Sbjct: 117 EYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVK 176 Query: 166 ILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMH--------YNQTVDIWSVGCIMAELL 217 I DFGLAR + + YV R P + WM Y D+WS G ++ E+ Sbjct: 177 ICDFGLARDIMSD-SNYVVRGNARLP---VKWMAPESLFEGIYTIKSDVWSYGILLWEIF 232 Query: 218 T-GRTLFPG 225 + G +PG Sbjct: 233 SLGVNPYPG 241 >4P5Q-A nrPDB Length = 361 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 52/203 (25%), Positives = 95/203 (46%), Gaps = 24/203 (11%) Query: 30 VGSGAYGSVCAA---FDTKTGLRVAVKKLSRPFQSIIHAKRTY-RELRLLKHMKHENVIG 85 VG+G +G VC+ +K + VA+K L + +R + E ++ H N+I Sbjct: 41 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTE--KQRRDFLGEASIMGQFDHPNIIR 98 Query: 86 LLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQF--LIYQILRGLKYIH 142 L V T ++ V +VT M L++ ++ +Q ++ I G+KY+ Sbjct: 99 LEGVVTKSKP------VMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLS 152 Query: 143 SADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYRAPEIML 195 +HRDL N+ +N + K+ DFGL+R +D+ G + RW +PE + Sbjct: 153 DMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW-TSPE-AI 210 Query: 196 NWMHYNQTVDIWSVGCIMAELLT 218 + + D+WS G ++ E+++ Sbjct: 211 AYRKFTSASDVWSYGIVLWEVMS 233 >6HV0-A nrPDB Length = 416 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 83/309 (26%), Positives = 130/309 (42%), Gaps = 83/309 (26%) Query: 30 VGSGAYGSVC--AAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM-KHENVIGL 86 +G GA G++ FD + VAVK++ S RE++LL+ +H NVI Sbjct: 16 LGHGAEGTIVYRGMFDNRD---VAVKRILPECFSFAD-----REVQLLRESDEHPNVI-- 65 Query: 87 LDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQ--FLIYQILRGLKYIHSA 144 F + +F Y+ L A L V+ + ++ L+ Q GL ++HS Sbjct: 66 -RYFCTEKD-RQFQ--YIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSL 121 Query: 145 DIIHRDLKPSNLAV---NEDCELK--ILDFGL------ARHTDDEMTGYVATRWYRAPEI 193 +I+HRDLKP N+ + N ++K I DFGL RH+ +G T + APE+ Sbjct: 122 NIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 181 Query: 194 MLNWMHYNQ--TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 + N TVDI+S GC+ ++ Sbjct: 182 LSEDCKENPTYTVDIFSAGCVFYYVI---------------------------------- 207 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPL------------AVDLLEKMLVLDSDKRITA 299 SE + + +SL + AN+ +GA L A +L+EKM+ +D KR +A Sbjct: 208 SEGSHPFGKSLQRQ-----ANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSA 262 Query: 300 AQALAHAYF 308 L H +F Sbjct: 263 KHVLKHPFF 271 >5VD3-A nrPDB Length = 311 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 90/216 (41%), Gaps = 11/216 (5%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 + +Q LS +G G+YG V + G AVK+ PF+ R E+ HE Sbjct: 57 QSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVG-----SHE 111 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC--QKLTDDHVQFLIYQILRGLK 139 V ++ EE +YL T L G L + L + V + L L Sbjct: 112 KVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALA 171 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV--ATRWYRAPEIMLNW 197 ++HS ++H D+KP+N+ + K+ DFGL G V Y APE++ Sbjct: 172 HLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQG- 230 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLK 233 Y D++S+G + E+ L G + QL+ Sbjct: 231 -SYGTAADVFSLGLTILEVACNMELPHGGEGWQQLR 265 >4XI2-A nrPDB Length = 446 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 51/209 (24%), Positives = 102/209 (48%), Gaps = 19/209 (9%) Query: 18 WEV-PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 WE+ P+ L +G+G +G V + VA+K + + + E +++ Sbjct: 182 WEIDPKDLTFLKELGTGQFG-VVKYGKWRGQYDVAIKMIR---EGSMSEDEFIEEAKVMM 237 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQ-KLTDDHVQFLIYQ 133 ++ HE ++ L V T R ++++T M G LN + + + + + + Sbjct: 238 NLSHEKLVQLYGVCTKQRP------IFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD 291 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-DDEMTGYVATRW---YR 189 + ++Y+ S +HRDL N VN+ +K+ DFGL+R+ DDE T V +++ + Sbjct: 292 VCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWS 351 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLT 218 PE+++ + ++ DIW+ G +M E+ + Sbjct: 352 PPEVLM-YSKFSSKSDIWAFGVLMWEIYS 379 >6E4F-A nrPDB Length = 290 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 51/209 (24%), Positives = 102/209 (48%), Gaps = 19/209 (9%) Query: 18 WEV-PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 WE+ P+ L +G+G +G V + VA+K + + + E +++ Sbjct: 26 WEIDPKDLTFLKELGTGQFGVVKYG-KWRGQYDVAIKMIK---EGSMSEDEFIEEAKVMM 81 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQ-KLTDDHVQFLIYQ 133 ++ HE ++ L V T R ++++T M G LN + + + + + + Sbjct: 82 NLSHEKLVQLYGVCTKQRP------IFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD 135 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-DDEMTGYVATRW---YR 189 + ++Y+ S +HRDL N VN+ +K+ DFGL+R+ DDE T V +++ + Sbjct: 136 VCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWS 195 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLT 218 PE+++ + ++ DIW+ G +M E+ + Sbjct: 196 PPEVLM-YSKFSSKSDIWAFGVLMWEIYS 223 >5TOS-A nrPDB Length = 395 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 100/215 (46%), Gaps = 31/215 (14%) Query: 28 SPVGSGAYGSVCAAF---------DTKTGLRVAVKKLSRPFQSIIHAKRTY-RELRLLKH 77 S +G G +G V + TGL +AVKKL+ Q R + E+ L Sbjct: 71 SVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN---QEGFQGHREWLTEINYLGQ 127 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQIL- 135 + H N++ L+ LE+ + + + + L N++ + FL + Sbjct: 128 LSHPNLVKLI-----GYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 Query: 136 ---RGLKYIHS--ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATR---- 186 +GL ++HS +I+RD+K SN+ ++ D K+ DFGLAR YV+TR Sbjct: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 Query: 187 -WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGR 220 Y APE M + H N D++S G ++ E+L+G+ Sbjct: 243 YGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSGK 276 >2RIO-A nrPDB Length = 434 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 80/314 (25%), Positives = 132/314 (42%), Gaps = 72/314 (22%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-HENVIGLLD 88 +G G+ G+V + G VAVK++ F I E++LL H NVI Sbjct: 23 LGYGSSGTVVFQ-GSFQGRPVAVKRMLIDFCDI-----ALMEIKLLTESDDHPNVIRYYC 76 Query: 89 VFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQF--------LIYQILRGLKY 140 T R L Y+ L +L ++V+ + ++D++++ L+ QI G+ + Sbjct: 77 SETTDRFL------YIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAH 130 Query: 141 IHSADIIHRDLKPSNLAVN-------------EDCELKILDFGLARHTDDEMTGY----- 182 +HS IIHRDLKP N+ V+ E+ + I DFGL + D + + Sbjct: 131 LHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLN 190 Query: 183 --VATRWYRAPEI------MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKL 234 T +RAPE+ + +++DI+S+GC+ +L+ + P D + Sbjct: 191 NPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILS-KGKHPFGDKYSRESN 249 Query: 235 ILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSD 294 I+R G L ++ R+ I A DL+ +M+ D Sbjct: 250 IIR-----GIFSLDEMKCLHDRSLIAE-------------------ATDLISQMIDHDPL 285 Query: 295 KRITAAQALAHAYF 308 KR TA + L H F Sbjct: 286 KRPTAMKVLRHPLF 299 >3G0E-A nrPDB Length = 336 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 63/238 (26%), Positives = 107/238 (44%), Gaps = 35/238 (14%) Query: 18 WEVPE-RYQNLSPVGSGAYGSVCAA-----FDTKTGLRVAVKKLSRPFQSIIHAKRTYRE 71 WE P R +G+GA+G V A + + VAVK L +P + + E Sbjct: 41 WEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKML-KPSAHLTEREALMSE 99 Query: 72 LRLLKHM-KHENVIGLLDVFT---PARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 L++L ++ H N++ LL T P + E+ + + + ++ + C K + + Sbjct: 100 LKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFI-CSKTSPAIM 158 Query: 128 QF------------LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT 175 + YQ+ +G+ ++ S + IHRDL N+ + KI DFGLAR Sbjct: 159 EDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI 218 Query: 176 DDEMTGYVA-------TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPG 225 ++ + YV +W APE + N + Y D+WS G + EL + G + +PG Sbjct: 219 KND-SNYVVKGNARLPVKW-MAPESIFNCV-YTFESDVWSYGIFLWELFSLGSSPYPG 273 >1NY3-A nrPDB Length = 400 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 58/205 (28%), Positives = 100/205 (48%), Gaps = 22/205 (10%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRL-LKHMKHENVIGLLD 88 +G G G V F+ +T + A+K L + RE+ L + + +++ ++D Sbjct: 70 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 122 Query: 89 VFTPARSLEEFNDVYLVTH--LMGADLNNIVKC---QKLTDDHVQFLIYQILRGLKYIHS 143 V+ +L L+ L G +L + ++ Q T+ ++ I ++Y+HS Sbjct: 123 VY---ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 Query: 144 ADIIHRDLKPSNL---AVNEDCELKILDFGLARHTD--DEMTGYVATRWYRAPEIMLNWM 198 +I HRD+KP NL + + LK+ DFG A+ T + +T T +Y APE+ L Sbjct: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV-LGPE 238 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLF 223 Y+++ D+WS+G IM LL G F Sbjct: 239 KYDKSCDMWSLGVIMYILLCGYPPF 263 >2H34-A nrPDB Length = 309 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 68/221 (30%), Positives = 103/221 (46%), Gaps = 18/221 (8%) Query: 21 PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS-IIHAKRTYRELRLLKHMK 79 P R + L VG G G V A DT VA+K +S S + R RE R ++ Sbjct: 35 PYRLRRL--VGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQ 92 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGL 138 +V+ + D L + D+ L+ G DL +++ Q L ++ QI L Sbjct: 93 EPHVVPIHDFGEIDGQL--YVDMRLIN---GVDLAAMLRRQGPLAPPRAVAIVRQIGSAL 147 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE----MTGYVATRWYRAPEIM 194 H+A HRD+KP N+ V+ D ++DFG+A T DE + V T +Y APE Sbjct: 148 DAAHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPE-R 206 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLI 235 + H DI+++ C++ E LTG + G DQL ++ Sbjct: 207 FSESHATYRADIYALTCVLYECLTGSPPYQG----DQLSVM 243 >3C51-A nrPDB Length = 543 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 55/204 (26%), Positives = 95/204 (46%), Gaps = 17/204 (8%) Query: 30 VGSGAYGSVCAAFDTKTG-LRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 +G G +G V A TG L K + + + E ++L + ++ L Sbjct: 193 LGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSL-- 250 Query: 89 VFTPARSLEEFNDVYLVTHLM-GADL-----NNIVKCQKLTDDHVQFLIYQILRGLKYIH 142 A + E D+ LV +M G D+ N + F QI+ GL+++H Sbjct: 251 ----AYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLH 306 Query: 143 SADIIHRDLKPSNLAVNEDCELKILDFGLA---RHTDDEMTGYVATRWYRAPEIMLNWMH 199 +II+RDLKP N+ +++D ++I D GLA + + GY T + APE++L Sbjct: 307 QRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLG-EE 365 Query: 200 YNQTVDIWSVGCIMAELLTGRTLF 223 Y+ +VD +++G + E++ R F Sbjct: 366 YDFSVDYFALGVTLYEMIAARGPF 389 >2OZA-A nrPDB Length = 356 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 58/205 (28%), Positives = 100/205 (48%), Gaps = 22/205 (10%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRL-LKHMKHENVIGLLD 88 +G G G V F+ +T + A+K L + RE+ L + + +++ ++D Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 78 Query: 89 VFTPARSLEEFNDVYLVTH--LMGADLNNIVKC---QKLTDDHVQFLIYQILRGLKYIHS 143 V+ +L L+ L G +L + ++ Q T+ ++ I ++Y+HS Sbjct: 79 VY---ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 135 Query: 144 ADIIHRDLKPSNL---AVNEDCELKILDFGLARHTD--DEMTGYVATRWYRAPEIMLNWM 198 +I HRD+KP NL + + LK+ DFG A+ T + +T T +Y APE+ L Sbjct: 136 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV-LGPE 194 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLF 223 Y+++ D+WS+G IM LL G F Sbjct: 195 KYDKSCDMWSLGVIMYILLCGYPPF 219 >3KA0-A nrPDB Length = 320 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 58/205 (28%), Positives = 100/205 (48%), Gaps = 22/205 (10%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRL-LKHMKHENVIGLLD 88 +G G G V F+ +T + A+K L + RE+ L + + +++ ++D Sbjct: 24 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 76 Query: 89 VFTPARSLEEFNDVYLVTH--LMGADLNNIVKC---QKLTDDHVQFLIYQILRGLKYIHS 143 V+ +L L+ L G +L + ++ Q T+ ++ I ++Y+HS Sbjct: 77 VY---ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 133 Query: 144 ADIIHRDLKPSNL---AVNEDCELKILDFGLARHTD--DEMTGYVATRWYRAPEIMLNWM 198 +I HRD+KP NL + + LK+ DFG A+ T + +T T +Y APE+ L Sbjct: 134 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEV-LGPE 192 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLF 223 Y+++ D+WS+G IM LL G F Sbjct: 193 KYDKSCDMWSLGVIMYILLCGYPPF 217 >1K9A-A nrPDB Length = 450 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 55/204 (26%), Positives = 98/204 (48%), Gaps = 19/204 (9%) Query: 27 LSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGL 86 L +G G +G V G +VAVK + ++ A+ E ++ ++H N++ L Sbjct: 198 LQTIGKGEFGDV--MLGDYRGNKVAVKCI----KNDATAQAFLAEASVMTQLRHSNLVQL 251 Query: 87 LDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQK---LTDDHVQFLIYQILRGLKYIH 142 L V +EE +Y+VT M L + ++ + L D + + ++Y+ Sbjct: 252 LGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 Query: 143 SADIIHRDLKPSNLAVNEDCELKILDFGLARH-TDDEMTGYVATRWYRAPEIMLNWMHYN 201 + +HRDL N+ V+ED K+ DFGL + + + TG + +W APE L ++ Sbjct: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKW-TAPE-ALREKKFS 364 Query: 202 QTVDIWSVGCIMAELLT-GRTLFP 224 D+WS G ++ E+ + GR +P Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYP 388 >5HLW-A nrPDB Length = 299 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 57/216 (26%), Positives = 99/216 (45%), Gaps = 23/216 (10%) Query: 30 VGSGAYGSVCAAF---DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGL 86 +G G +G V + + AVK L+R I + E ++K H NV+ L Sbjct: 28 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDFSHPNVLSL 86 Query: 87 LDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK---LTDDHVQFLIYQILRGLKYIHS 143 L + RS E + + ++ ++ DL N ++ + D + F + Q+ +G+KY+ S Sbjct: 87 LGICL--RS--EGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGL-QVAKGMKYLAS 141 Query: 144 ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWM----- 198 +HRDL N ++E +K+ DFGLAR D+ Y + ++ + WM Sbjct: 142 KKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKE--YYSVHNKTGAKLPVKWMALESL 199 Query: 199 ---HYNQTVDIWSVGCIMAELLT-GRTLFPGTDHID 230 + D+WS G ++ EL+T G +P + D Sbjct: 200 QTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFD 235 >3BEA-A nrPDB Length = 333 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 64/236 (27%), Positives = 111/236 (47%), Gaps = 35/236 (14%) Query: 18 WEVPER-YQNLSPVGSGAYGSVCAAFDTKTG-----LRVAVKKLSRPFQSIIHA---KRT 68 WE P Q +G+GA+G V A G L+VAVK L +S HA + Sbjct: 41 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML----KSTAHADEKEAL 96 Query: 69 YRELRLLKHM-KHENVIGLLDVFT---PARSLEEF-------NDVYLVTHLMGADLNNIV 117 EL+++ H+ +HEN++ LL T P + E+ N + + ++ D + Sbjct: 97 MSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAI 156 Query: 118 KCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD 177 L+ + Q+ +G+ ++ S + IHRD+ N+ + KI DFGLAR + Sbjct: 157 ANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMN 216 Query: 178 EMTGYVA-------TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPG 225 + + Y+ +W APE + + ++ Q+ D+WS G ++ E+ + G +PG Sbjct: 217 D-SNYIVKGNARLPVKW-MAPESIFDCVYTVQS-DVWSYGILLWEIFSLGLNPYPG 269 >1BYG-A nrPDB Length = 278 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 55/204 (26%), Positives = 98/204 (48%), Gaps = 19/204 (9%) Query: 27 LSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGL 86 L +G G +G V G +VAVK + ++ A+ E ++ ++H N++ L Sbjct: 26 LQTIGKGEFGDV--MLGDYRGNKVAVKCI----KNDATAQAFLAEASVMTQLRHSNLVQL 79 Query: 87 LDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQK---LTDDHVQFLIYQILRGLKYIH 142 L V +EE +Y+VT M L + ++ + L D + + ++Y+ Sbjct: 80 LGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 134 Query: 143 SADIIHRDLKPSNLAVNEDCELKILDFGLARH-TDDEMTGYVATRWYRAPEIMLNWMHYN 201 + +HRDL N+ V+ED K+ DFGL + + + TG + +W APE L ++ Sbjct: 135 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKW-TAPE-ALREKKFS 192 Query: 202 QTVDIWSVGCIMAELLT-GRTLFP 224 D+WS G ++ E+ + GR +P Sbjct: 193 TKSDVWSFGILLWEIYSFGRVPYP 216 >4PWN-A nrPDB Length = 274 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 72/289 (24%), Positives = 128/289 (44%), Gaps = 41/289 (14%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G++ +V DT+T + VA +L + +R E +LK ++H N++ D Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDS 77 Query: 90 FTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHV-QFLIYQILRGLKYIHSAD-- 145 + +++ + LVT LM L +K K+ V + QIL+GL+++H+ Sbjct: 78 WES--TVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPP 135 Query: 146 IIHRDLKPSNLAV-NEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMH---YN 201 IIHRDLK N+ + +KI D GLA E A PE M M+ Y+ Sbjct: 136 IIHRDLKCDNIFITGPTGSVKIGDLGLATL---EKRASFAKSVIGTPEFMAPEMYEEKYD 192 Query: 202 QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQS 261 ++VD+++ G M E+ T +P ++ +A+ Y + Sbjct: 193 ESVDVYAFGMCMLEMATSE--YPYSE-----------------------CQNAAQIYRRV 227 Query: 262 LTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 + + +F V I P +++E + + D+R + L HA+F + Sbjct: 228 TSGVKPASFDKVAI---PEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >3OMV-A nrPDB Length = 307 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 67/245 (27%), Positives = 115/245 (46%), Gaps = 46/245 (18%) Query: 18 WEVPERYQNLSP-VGSGAYGSVCAAFDTKTGLRVAVK--KLSRPFQSIIHAKRTYRELRL 74 WE+ LS +GSG++G+V + K VAVK K+ P A R E+ + Sbjct: 31 WEIEASEVMLSTRIGSGSFGTV---YKGKWHGDVAVKILKVVDPTPEQFQAFRN--EVAV 85 Query: 75 LKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFL--I 131 L+ +H N++ + T +++ +VT G+ L + Q+ Q + Sbjct: 86 LRKTRHVNILLFMGYMTK-------DNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIA 138 Query: 132 YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW---- 187 Q +G+ Y+H+ +IIHRD+K +N+ ++E +KI DFGLA V +RW Sbjct: 139 RQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLAT---------VKSRWSGSQ 189 Query: 188 ----------YRAPEI--MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLI 235 + APE+ M + ++ D++S G ++ EL+TG + HI+ I Sbjct: 190 QVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPY---SHINNRDQI 246 Query: 236 LRLVG 240 + +VG Sbjct: 247 IFMVG 251 >4Y93-A nrPDB Length = 446 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 49/209 (23%), Positives = 101/209 (48%), Gaps = 19/209 (9%) Query: 18 WEV-PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 WE+ P+ L +G+G +G V + VA+K + + + E +++ Sbjct: 183 WEIDPKDLTFLKELGTGQFGVVKYG-KWRGQYDVAIKMIK---EGSMSEDEFIEEAKVMM 238 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQ-KLTDDHVQFLIYQ 133 ++ HE ++ L V T R ++++T M G LN + + + + + + Sbjct: 239 NLSHEKLVQLYGVCTKQRP------IFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD 292 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-DDEMTGYVATRW---YR 189 + ++Y+ S +HRDL N VN+ +K+ DFG+ R+ DDE T +++ + Sbjct: 293 VCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWA 352 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLT 218 +PE+++ + ++ DIW+ G +M E+ + Sbjct: 353 SPEVLM-YSKFSSKSDIWAFGVLMWEIYS 380 >2Y6O-A nrPDB Length = 291 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 53/203 (26%), Positives = 92/203 (45%), Gaps = 24/203 (11%) Query: 30 VGSGAYGSVCAAFDTKTGLR---VAVKKLSRPFQSIIHAKRTY-RELRLLKHMKHENVIG 85 +G G +G VC+ G R VA+K L + +R + E ++ H N+I Sbjct: 22 IGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTD--KQRRDFLSEASIMGQFDHPNIIH 79 Query: 86 LLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ--KLTDDHVQFLIYQILRGLKYIH 142 L V T + V ++T M L+ ++ + T + ++ I G+KY+ Sbjct: 80 LEGVVTKCKP------VMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLS 133 Query: 143 SADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYRAPEIML 195 +HRDL N+ VN + K+ DFG++R +D+ G + RW APE + Sbjct: 134 DMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWT-APE-AI 191 Query: 196 NWMHYNQTVDIWSVGCIMAELLT 218 + + D+WS G +M E+++ Sbjct: 192 AYRKFTSASDVWSYGIVMWEVMS 214 >4YHJ-A nrPDB Length = 584 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/200 (27%), Positives = 95/200 (47%), Gaps = 12/200 (6%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR-TYRELRLLKHMKHENVIGLLD 88 +G G +G VCA TG A KKL + + E R+L+ ++ V+ L Sbjct: 193 LGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAY 252 Query: 89 VFTPARSLEEFNDVYLVTHLMGADLN-NIVKCQKLTDDHVQFLIY--QILRGLKYIHSAD 145 + +L ++T + G DL +I D + + Y ++ GL+ + Sbjct: 253 AYETKDAL-----CLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRER 307 Query: 146 IIHRDLKPSNLAVNEDCELKILDFGLARHTDD--EMTGYVATRWYRAPEIMLNWMHYNQT 203 I++RDLKP N+ +++ ++I D GLA + + G V T Y APE++ N Y + Sbjct: 308 IVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN-EKYTFS 366 Query: 204 VDIWSVGCIMAELLTGRTLF 223 D W +GC++ E++ G + F Sbjct: 367 PDWWGLGCLIYEMIQGHSPF 386 >4OTD-A nrPDB Length = 341 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 56/218 (25%), Positives = 103/218 (47%), Gaps = 21/218 (9%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP-------FQSIIHAKRTYRELRL 74 E ++ L+ +G G +G V + +G A+K L + +S++ KR L Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRI---LAA 68 Query: 75 LKHMKHENVIGLLDVF-TPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQ 133 + H ++ L F TP + +++ + G DL + ++ F Sbjct: 69 VTSAGHPFLVNLFGCFQTPE------HVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSAC 122 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT---DDEMTGYVATRWYRA 190 ++ GL+++H I++RDLK NL ++ + +KI DFGL + D + + T + A Sbjct: 123 VVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLA 182 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDH 228 PE++ + Y + VD W +G ++ E+L G + FPG D Sbjct: 183 PEVLTD-TSYTRAVDWWGLGVLLYEMLVGESPFPGDDE 219 >3DKO-A nrPDB Length = 318 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 49/202 (24%), Positives = 93/202 (46%), Gaps = 22/202 (10%) Query: 30 VGSGAYGSVCAA---FDTKTGLRVAVKKLSRPFQSIIHAKRTYR-ELRLLKHMKHENVIG 85 +G+G +G VC+ K + VA+K L + +R + E ++ H NV+ Sbjct: 51 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTE--KQRRDFLCEASIMGQFDHPNVVH 108 Query: 86 LLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ--KLTDDHVQFLIYQILRGLKYIHS 143 L V T + + + ++ + L+ ++ + T + ++ I G++Y+ Sbjct: 109 LEGVVTRGKPV-----MIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLAD 163 Query: 144 ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYRAPEIMLN 196 +HRDL N+ VN + K+ DFGL+R +D+ G + RW APE + Sbjct: 164 MGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRW-TAPE-AIQ 221 Query: 197 WMHYNQTVDIWSVGCIMAELLT 218 + + D+WS G +M E+++ Sbjct: 222 YRKFTSASDVWSYGIVMWEVMS 243 >4PL5-B nrPDB Length = 435 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 80/309 (25%), Positives = 129/309 (41%), Gaps = 83/309 (26%) Query: 30 VGSGAYGSVC--AAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM-KHENVIGL 86 +G GA G++ FD + VAVK++ S RE++LL+ +H NVI Sbjct: 35 LGHGAEGTIVYKGMFDNRD---VAVKRILPECFSFAD-----REVQLLRESDEHPNVIR- 85 Query: 87 LDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQ--FLIYQILRGLKYIHSA 144 + +F Y+ L A L V+ + ++ L++Q GL ++HS Sbjct: 86 ---YFCTEKDRQFQ--YIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSL 140 Query: 145 DIIHRDLKPSNLAV---NEDCELK--ILDFGL------ARHTDDEMTGYVATRWYRAPEI 193 +I+HRDLKP N+ + N +K I DFGL RH+ +G T + APE+ Sbjct: 141 NIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 200 Query: 194 MLNWMHYNQ--TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 + N TVDI+S GC+ ++ Sbjct: 201 LSEDCKDNPTYTVDIFSAGCVFYYVI---------------------------------- 226 Query: 252 SESARNYIQSLTQMPKMNFANVFIGA------------NPLAVDLLEKMLVLDSDKRITA 299 SE + +SL + AN+ +GA + +A +L+EKM+ +D +R +A Sbjct: 227 SEGYHPFGKSLQRQ-----ANILLGACNLDCFHSDKHEDVIARELIEKMIAMDPQQRPSA 281 Query: 300 AQALAHAYF 308 L H +F Sbjct: 282 KHVLKHPFF 290 >3TKU-A nrPDB Length = 433 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 105/215 (48%), Gaps = 20/215 (9%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRT-YRELR-LLKHMK 79 E ++ + +G GA+G V A K R+ K+ ++ + A+ +RE R +L + Sbjct: 90 EDFEIIKVIGRGAFGEV-AVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGD 148 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVT-HLMGADLNNIVKC--QKLTDDHVQFLIYQILR 136 + + L F ++ N +YLV + +G DL ++ KL +D +F I +++ Sbjct: 149 CQWITALHYAF------QDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVL 202 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY----VATRWYRAPE 192 + IH +HRD+KP N+ ++ + +++ DFG +D+ T V T Y +PE Sbjct: 203 AIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPE 262 Query: 193 I---MLNWM-HYNQTVDIWSVGCIMAELLTGRTLF 223 I M + M Y D WS+G M E+L G T F Sbjct: 263 ILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPF 297 >2OGV-A nrPDB Length = 317 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 65/238 (27%), Positives = 110/238 (46%), Gaps = 43/238 (18%) Query: 18 WEVPER-YQNLSPVGSGAYGSVCAAFDTKTG-----LRVAVKKLSRPFQSIIHAKRT--- 68 WE P Q +G+GA+G V A G L+VAVK L +S HA Sbjct: 33 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML----KSTAHADEKEAL 88 Query: 69 YRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTD--- 124 EL+++ H+ +HEN++ LL T + + + + DL N ++ + D Sbjct: 89 MSELKIMSHLGQHENIVNLLGACTHGGPV-----LVITEYCCYGDLLNFLRRKAEADLDK 143 Query: 125 ---------DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT 175 D + F Q+ +G+ ++ S + IHRD+ N+ + KI DFGLAR Sbjct: 144 EDGRPLELRDLLHF-SSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI 202 Query: 176 DDEMTGYVA-------TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPG 225 ++ + Y+ +W APE + + ++ Q+ D+WS G ++ E+ + G +PG Sbjct: 203 MND-SNYIVKGNARLPVKW-MAPESIFDCVYTVQS-DVWSYGILLWEIFSLGLNPYPG 257 >3FXW-A nrPDB Length = 336 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 68/256 (26%), Positives = 118/256 (46%), Gaps = 44/256 (17%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKL---SRPFQSIIHAKRTYRELRLLKHMKHENVIGL 86 +G G G V F +TG + A+K L + Q + H + +++ + Sbjct: 37 LGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQA---------SGGPHIVCI 87 Query: 87 LDVFT----PARSLEEFNDVYLVTHLMGADLNNIVKC---QKLTDDHVQFLIYQILRGLK 139 LDV+ R L + ++ + G +L + ++ Q T+ ++ I ++ Sbjct: 88 LDVYENMHHGKRCL-----LIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQ 142 Query: 140 YIHSADIIHRDLKPSNL---AVNEDCELKILDFGLARH-TDDEMTGYVATRWYRAPEIML 195 ++HS +I HRD+KP NL + +D LK+ DFG A+ T + + T +Y APE+ L Sbjct: 143 FLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEV-L 201 Query: 196 NWMHYNQTVDIWSVGCIMAELL---------TGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 Y+++ D+WS+G IM LL TG+ + PG + ++ L G P E Sbjct: 202 GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGM----KRRIRLGQYGFPNPEW 257 Query: 247 LKKISSESARNYIQSL 262 + SE A+ I+ L Sbjct: 258 SE--VSEDAKQLIRLL 271 >6BXI-A nrPDB Length = 333 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 62/242 (25%), Positives = 97/242 (40%), Gaps = 54/242 (22%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E +++L +G GA+G V TG A+K L K E + H++ E Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILR---------KADMLEKEQVGHIRAE 56 Query: 82 -NVIGLLDVFTPARSLEEFND---VYLVTHLM-GADLNNIV-KCQKLTDDHVQFLIYQIL 135 +++ D + F D +YL+ + G D+ ++ K LT++ QF I + + Sbjct: 57 RDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETV 116 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA----------------------- 172 + IH IHRD+KP NL ++ +K+ DFGL Sbjct: 117 LAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDF 176 Query: 173 ---------------RHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 R+ V T Y APE+ + YN+ D WS+G IM E+L Sbjct: 177 TFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQ-TGYNKLCDWWSLGVIMYEML 235 Query: 218 TG 219 G Sbjct: 236 IG 237 >2X7G-A nrPDB Length = 389 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 88/364 (24%), Positives = 147/364 (40%), Gaps = 86/364 (23%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 RY + +G G + +V +D + G R K+ + Q + + E++LLK ++ + Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQ-GKRFVAMKVVKSAQH--YTETALDEIKLLKCVRESD 88 Query: 83 --------VIGLLDVFTPARSLEEFNDVY--LVTHLMGADL-NNIVKC--QKLTDDHVQF 129 V+ L+D F + N ++ +V ++G L I+K Q L V+ Sbjct: 89 PSDPNKDMVVQLIDDF----KISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKS 144 Query: 130 LIYQILRGLKYIHS-ADIIHRDLKPSNLAVNED--------------------------- 161 +I Q+L+GL Y+HS IIH D+KP N+ + D Sbjct: 145 IIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAV 204 Query: 162 --------------------CELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYN 201 +KI D G A T + TR YR+ E+++ Y+ Sbjct: 205 STAPAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIG-AGYS 263 Query: 202 QTVDIWSVGCIMAELLTGRTLF---PGTDHI---DQLKLILRLVGTPGAE--LLKKISSE 253 DIWS C+ EL TG LF G D+ D + I+ L+G+ L K S E Sbjct: 264 TPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSRE 323 Query: 254 --SARNYIQSLTQMPKMNFANVFIGANPLA-------VDLLEKMLVLDSDKRITAAQALA 304 + R ++ +T++ + +V + D L ML + +KR +A + L Sbjct: 324 FFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLR 383 Query: 305 HAYF 308 H + Sbjct: 384 HPWL 387 >4IDT-A nrPDB Length = 356 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/200 (29%), Positives = 93/200 (46%), Gaps = 23/200 (11%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G++G V D +TG + AVKK+ + A+ EL + ++ L Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRL---EVFRAE----ELMACAGLTSPRIVPLYGA 134 Query: 90 FTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGLKYIHSADIIH 148 + F ++ L G L +VK Q L +D + + Q L GL+Y+HS I+H Sbjct: 135 VREGPWVNIFMEL-----LEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILH 189 Query: 149 RDLKPSNLAVNED-CELKILDFGLA------RHTDDEMTG-YV-ATRWYRAPEIMLNWMH 199 D+K N+ ++ D + DFG A D +TG Y+ T + APE++L Sbjct: 190 GDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLG-RS 248 Query: 200 YNQTVDIWSVGCIMAELLTG 219 + VD+WS C+M +L G Sbjct: 249 CDAKVDVWSSCCMMLHMLNG 268 >2VWV-A nrPDB Length = 302 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 53/205 (25%), Positives = 92/205 (44%), Gaps = 26/205 (12%) Query: 30 VGSGAYGSVCAAFDTKTGLR---VAVKKLSRPFQSIIHAKRTY-RELRLLKHMKHENVIG 85 +G+G +G VC G + VA+K L + +R + E ++ +H N+I Sbjct: 24 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTE--RQRREFLSEASIMGQFEHPNIIR 81 Query: 86 LLDVFT---PARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIH 142 L V T P L EF + + + LN+ + T + ++ I G++Y+ Sbjct: 82 LEGVVTNSMPVMILTEFMENGALDSFL--RLND----GQFTVIQLVGMLRGIASGMRYLA 135 Query: 143 SADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD---------EMTGYVATRWYRAPEI 193 +HRDL N+ VN + K+ DFGL+R ++ + G + RW APE Sbjct: 136 EMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWT-APE- 193 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLT 218 + + + D WS G +M E+++ Sbjct: 194 AIAFRKFTSASDAWSYGIVMWEVMS 218 >4CRS-A nrPDB Length = 341 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 62/267 (23%), Positives = 116/267 (43%), Gaps = 37/267 (13%) Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR--- 57 MSQ+R F Q+ ++ + + G +G V A T A+K L + Sbjct: 2 MSQQRFQFNLQD-----------FRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDI 50 Query: 58 ----PFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADL 113 S++ KR + + ++H ++ L F + +++ + G DL Sbjct: 51 VARDEVDSLMCEKRIFE---TVNSVRHPFLVNLFACFQTKEHV-----CFVMEYAAGGDL 102 Query: 114 NNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR 173 + ++ F ++ GL+Y+H I++RDLK NL ++ + +KI DFGL + Sbjct: 103 MMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCK 162 Query: 174 HT---DDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHID 230 D + + T + APE+ L Y + VD W +G ++ E+L G + FPG D + Sbjct: 163 EGMGYGDRTSTFCGTPEFLAPEV-LTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEE 221 Query: 231 QLKLIL-------RLVGTPGAELLKKI 250 I+ R + T +++++ Sbjct: 222 VFDSIVNDEVRYPRFLSTEAISIMRRL 248 >3SXS-A nrPDB Length = 268 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 52/199 (26%), Positives = 95/199 (47%), Gaps = 18/199 (9%) Query: 27 LSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGL 86 L +GSG +G V K VAVK + + + ++E + + + H ++ Sbjct: 13 LKELGSGQFGVVKLG-KWKGQYDVAVKMIK---EGSMSEDEFFQEAQTMMKLSHPKLVKF 68 Query: 87 LDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQK-LTDDHVQFLIYQILRGLKYIHS 143 V + +E+ +Y+VT + G LN + K L + + Y + G+ ++ S Sbjct: 69 YGVCS-----KEY-PIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLES 122 Query: 144 ADIIHRDLKPSNLAVNEDCELKILDFGLARHT-DDEMTGYVATRW---YRAPEIMLNWMH 199 IHRDL N V+ D +K+ DFG+ R+ DD+ V T++ + APE+ ++ Sbjct: 123 HQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEV-FHYFK 181 Query: 200 YNQTVDIWSVGCIMAELLT 218 Y+ D+W+ G +M E+ + Sbjct: 182 YSSKSDVWAFGILMWEVFS 200 >5XD6-A nrPDB Length = 305 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 59/225 (26%), Positives = 102/225 (45%), Gaps = 38/225 (16%) Query: 19 EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKL---SRPFQSIIHAKRTYRELRLL 75 ++ + Y + S +G G+YG V K+G A+KKL +P Q + ++ ++ Sbjct: 19 DITDNYGSKSLIGEGSYGRVFYGI-LKSGKAAAIKKLDSSKQPDQEFL------AQVSMV 71 Query: 76 KHMKHENVIGLLDV------------FTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLT 123 ++ ENV+ LL + P SL + ++ + GA ++ + Sbjct: 72 SRLRQENVVALLGYCVDGPLRVLAYEYAPNGSLHDI--LHGRKGVKGAQPGPVLSWHQRV 129 Query: 124 DDHVQFLIYQILRGLKYIH---SADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD--- 177 + RGL+Y+H + +IHRD+K SN+ + +D KI DF L+ D Sbjct: 130 K-----IAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAA 184 Query: 178 --EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGR 220 T + T Y APE + ++ D++S G ++ ELLTGR Sbjct: 185 RLHSTRVLGTFGYHAPEYAMTGTLSTKS-DVYSFGVVLLELLTGR 228 >3C1X-A nrPDB Length = 373 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 56/216 (25%), Positives = 99/216 (45%), Gaps = 23/216 (10%) Query: 30 VGSGAYGSVCAAF---DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGL 86 +G G +G V + + AVK L+R I + E ++K H NV+ L Sbjct: 97 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDFSHPNVLSL 155 Query: 87 LDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK---LTDDHVQFLIYQILRGLKYIHS 143 L + RS E + + ++ ++ DL N ++ + D + F + Q+ +G+K++ S Sbjct: 156 LGICL--RS--EGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGL-QVAKGMKFLAS 210 Query: 144 ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWM----- 198 +HRDL N ++E +K+ DFGLAR D+ V + ++ + WM Sbjct: 211 KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNK--TGAKLPVKWMALESL 268 Query: 199 ---HYNQTVDIWSVGCIMAELLT-GRTLFPGTDHID 230 + D+WS G ++ EL+T G +P + D Sbjct: 269 QTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFD 304 >5B2L-A nrPDB Length = 324 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 98/209 (46%), Gaps = 17/209 (8%) Query: 25 QNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVI 84 +NL +GSG G V KTG +AVK++ R KR +L ++ +K + Sbjct: 20 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKE-ENKRILMDLDVV--LKSHDCP 76 Query: 85 GLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK--LTDDHVQFLIYQILRGLKYIH 142 ++ F + DV++ LMG + K + + + + + I++ L Y+ Sbjct: 77 YIVQCFG---TFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLK 133 Query: 143 SA-DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIM----L 195 +IHRD+KPSN+ ++E ++K+ DFG++ D T Y APE + Sbjct: 134 EKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDP 193 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFP 224 Y+ D+WS+G + EL TG+ FP Sbjct: 194 TKPDYDIRADVWSLGISLVELATGQ--FP 220 >4Y83-A nrPDB Length = 332 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 54/221 (24%), Positives = 106/221 (47%), Gaps = 20/221 (9%) Query: 6 PTFYRQELNKTIWEVPER--YQNLSP--VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 P R +++ + +P + Y+N+ + GA+G V A D KT R+A K + Sbjct: 53 PQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIP----- 107 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 + K + E++ +HEN+ L ++ +++ G+ L + C Sbjct: 108 VDQFKPSDVEIQAC--FRHENIAELYGAVLWGETVH----LFMEAGEGGSVLEKLESCGP 161 Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM-- 179 + + + ++ +L+GL ++HS +IH D+KPSN+ V + ++DFGL+ +++ Sbjct: 162 MREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNI-VFMSTKAVLVDFGLSVQMTEDVYF 220 Query: 180 -TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTG 219 T Y +PE++L H + DI+S+G + + TG Sbjct: 221 PKDLRGTEIYMSPEVILCRGHSTKA-DIYSLGATLIHMQTG 260 >2PMN-X nrPDB Length = 348 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 52/186 (27%), Positives = 84/186 (45%), Gaps = 14/186 (7%) Query: 127 VQFLIYQILRGLKYIHS-ADIIHRDLKPSNLAVNEDCELKILDFGLARH-TDDEMTGYVA 184 ++ +I +L YIH+ +I HRD+KPSN+ ++++ +K+ DFG + + D ++ G Sbjct: 153 IKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVDKKIKGSRG 212 Query: 185 TRWYRAPEIMLNWMHYN-QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPG 243 T + PE N YN VDIWS+G + + F L + LV Sbjct: 213 TYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFS---------LKISLVELFN 263 Query: 244 AELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQAL 303 K I RN+ K +N F+ +D L+ L + +RIT+ AL Sbjct: 264 NIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNED--IDFLKLFLRKNPAERITSEDAL 321 Query: 304 AHAYFA 309 H + A Sbjct: 322 KHEWLA 327 >4F9B-A nrPDB Length = 361 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 69/243 (28%), Positives = 107/243 (44%), Gaps = 56/243 (23%) Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE-LKILDFGLARHTDD--- 177 L+ V+ + + + LK IH I+HRD+KPSN N + ++DFGLA+ T D Sbjct: 114 LSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKI 173 Query: 178 EMTGYV----------------------------ATRWYRAPEIMLNWMHYNQTVDIWSV 209 E+ +V T +RAPE++ + +D+WS Sbjct: 174 ELLKFVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSA 233 Query: 210 GCIMAELLTGR-TLFPGTDHIDQLKLILRLVG---------TPGAELL--KKISSESARN 257 G I LL+GR + +D + L I+ + G T G +L K++ ++ R Sbjct: 234 GVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRK 293 Query: 258 YIQSLTQM----PKM-----NFANVFIGANPL---AVDLLEKMLVLDSDKRITAAQALAH 305 + L M PK+ A G N + A DLL+K+L L+ RITA +AL H Sbjct: 294 LCERLRGMDSSTPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLH 353 Query: 306 AYF 308 +F Sbjct: 354 PFF 356 >4EBW-A nrPDB Length = 304 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 56/226 (24%), Positives = 100/226 (44%), Gaps = 22/226 (9%) Query: 22 ERYQNLSPVGSGAYGSVCAAF---DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 ER + +G G +G V L VA+K + K +E ++ Sbjct: 38 ERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREK-FLQEALTMRQF 96 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQKLTDDHVQFLIY--QIL 135 H +++ L+ V T N V+++ L +L + ++ +K + D ++Y Q+ Sbjct: 97 DHPHIVKLIGVITE-------NPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLS 149 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM-----TGYVATRWYRA 190 L Y+ S +HRD+ N+ V+ + +K+ DFGL+R+ +D G + +W A Sbjct: 150 TALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM-A 208 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLI 235 PE +N+ + D+W G M E+L G F G + D + I Sbjct: 209 PE-SINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI 253 >5AMN-A nrPDB Length = 299 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 59/233 (25%), Positives = 96/233 (41%), Gaps = 34/233 (14%) Query: 18 WEVPERYQNLSP-VGSGAYGSVCAA----FDTKTGLRVAVKKLSRPFQSIIHAKRTYREL 72 WE P + L +G G +G V A + G K+ + S + E Sbjct: 18 WEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEF 77 Query: 73 RLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK----------- 121 +LK + H +VI L + L + +V + L ++ + Sbjct: 78 NVLKQVNHPHVIKLYGACSQDGPL-----LLIVEYAKYGSLRGFLRESRKVGPGYPDERA 132 Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG 181 LT + +QI +G++Y+ ++HRDL N+ V E ++KI DFGL+R +E Sbjct: 133 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE-DS 191 Query: 182 YVATRWYRAPEIMLNWMH--------YNQTVDIWSVGCIMAELLT-GRTLFPG 225 YV R P + WM Y D+WS G ++ E++T G +PG Sbjct: 192 YVKRSQGRIP---VKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG 241 >3KRL-A nrPDB Length = 335 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 63/243 (25%), Positives = 110/243 (45%), Gaps = 47/243 (19%) Query: 18 WEVPER-YQNLSPVGSGAYGSVCAAFDTKTG-----LRVAVKKLSRPFQSIIHAKRT--- 68 WE P Q +G+GA+G V A G L+VAVK L +S HA Sbjct: 41 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML----KSTAHADEKEAL 96 Query: 69 YRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK------ 121 EL+++ H+ +HEN++ LL T + + + + DL N ++ ++ Sbjct: 97 MSELKIMSHLGQHENIVNLLGACTHGGPV-----LVITEYCCYGDLLNFLRRKRPPGLEY 151 Query: 122 -----------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFG 170 L+ + Q+ +G+ ++ S + IHRD+ N+ + KI DFG Sbjct: 152 SYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFG 211 Query: 171 LARHTDDEMTGYVA-------TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL 222 LAR ++ + Y+ +W APE + + ++ Q+ D+WS G ++ E+ + G Sbjct: 212 LARDIMND-SNYIVKGNARLPVKW-MAPESIFDCVYTVQS-DVWSYGILLWEIFSLGLNP 268 Query: 223 FPG 225 +PG Sbjct: 269 YPG 271 >5U6B-A nrPDB Length = 307 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 100/216 (46%), Gaps = 19/216 (8%) Query: 30 VGSGAYGSVCAA--FDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLL 87 +G G +G+V + L+VAVK + + + E +K H NV+ L+ Sbjct: 31 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLI 90 Query: 88 DVFTPARSLEEF-NDVYLVTHLMGADLNNIVKCQKLTDDHV----QFLI---YQILRGLK 139 V E F V ++ + DL++ + +L D V Q L+ I G++ Sbjct: 91 GVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGME 150 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTGYVA---TRWYRAPEI 193 Y+ + IHRDL N +NE+ + + DFGL++ + D G +A +W A E Sbjct: 151 YLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWI-AIES 209 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDH 228 + + + Y D+WS G M E+ T G+T +PG ++ Sbjct: 210 LADRV-YTSKSDVWSFGVTMWEIATRGQTPYPGVEN 244 >5UIU-A nrPDB Length = 323 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 63/221 (28%), Positives = 108/221 (48%), Gaps = 25/221 (11%) Query: 28 SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ-SIIHAKRTY-RELRLLKHMKHENVIG 85 + +G G +G V + T VAVKKL+ + K+ + +E++++ +HEN++ Sbjct: 53 NKMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVE 110 Query: 86 LLDVFTPARSLEEFNDVYLV-THLMGADLNNIVKCQKLTDD---HVQFLIYQ-ILRGLKY 140 LL + +D+ LV ++ L + + C T H++ I Q G+ + Sbjct: 111 LLGFSSDG------DDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINF 164 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD----EMTG-YVATRWYRAPEIML 195 +H IHRD+K +N+ ++E KI DFGLAR ++ MT V T Y APE + Sbjct: 165 LHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR 224 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 + DI+S G ++ E++TG P D + +L+L Sbjct: 225 GEI--TPKSDIYSFGVVLLEIITG---LPAVDEHREPQLLL 260 >2J0K-A nrPDB Length = 656 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 57/227 (25%), Positives = 101/227 (44%), Gaps = 24/227 (10%) Query: 22 ERYQNLSPVGSGAYGSVCAAF---DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 ER + +G G +G V + VA+K + K +E ++ Sbjct: 390 ERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREK-FLQEALTMRQF 448 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQKLTDDHVQFLIY--QIL 135 H +++ L+ V T N V+++ L +L + ++ +K + D ++Y Q+ Sbjct: 449 DHPHIVKLIGVITE-------NPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLS 501 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNE-DCELKILDFGLARHTDDEM-----TGYVATRWYR 189 L Y+ S +HRD+ N+ V+ DC +K+ DFGL+R+ +D G + +W Sbjct: 502 TALAYLESKRFVHRDIAARNVLVSATDC-VKLGDFGLSRYMEDSTYYKASKGKLPIKWM- 559 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLI 235 APE +N+ + D+W G M E+L G F G + D + I Sbjct: 560 APE-SINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI 605 >5LPZ-A nrPDB Length = 332 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 98/222 (44%), Gaps = 46/222 (20%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHA-----KRTYRELRLLKHM 78 + N S +GSG +G V A K G VA+KKL IH + E+ + + Sbjct: 19 FHNDSLIGSGGFGDVYKAI-LKDGSAVAIKKL-------IHVSGQGDREFMAEMETIGKI 70 Query: 79 KHENVIGLLDV------------FTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDH 126 KH N++ LL F SLE DV G LN + + Sbjct: 71 KHRNLVPLLGYCKVGDERLLVYEFMKYGSLE---DVLHDPKKAGVKLNWSTRRK------ 121 Query: 127 VQFLIYQILRGLKYIH---SADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDE 178 + RGL ++H S IIHRD+K SN+ ++E+ E ++ DFG+AR T Sbjct: 122 ---IAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLS 178 Query: 179 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGR 220 ++ T Y PE ++ + D++S G ++ ELLTG+ Sbjct: 179 VSTLAGTPGYVPPEYYQSF-RCSTKGDVYSYGVVLLELLTGK 219 >4TPT-A nrPDB Length = 303 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 55/214 (25%), Positives = 95/214 (44%), Gaps = 36/214 (16%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTY-RELRLLKHMKHENVIGLLD 88 +G G +G TG + +K+L R + ++T+ E+++++ + H NV+ + Sbjct: 8 LGKGFFGQAIKVTHKATGKVMVMKELIRCDE---ETQKTFLTEVKVMRSLDHPNVLKFIG 64 Query: 89 VFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLT--DDHVQFLIYQILRGLKYIHSADI 146 V + L L ++ G L + ++ V+F I G+ Y+HS I Sbjct: 65 VLYKDKKLN-----LLTEYIEGGTLKDFLRSMDPFPWQQKVRF-AKGIASGMAYLHSMCI 118 Query: 147 IHRDLKPSNLAVNEDCELKILDFGLAR---------------------HTDDEMTGY--V 183 IHRDL N + D + + DFGL+R +D Y V Sbjct: 119 IHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVV 178 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 ++ APE MLN Y++TVDI+S G ++ E++ Sbjct: 179 GNPYWMAPE-MLNGKSYDETVDIFSFGIVLCEII 211 >5LPV-A nrPDB Length = 296 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 98/222 (44%), Gaps = 46/222 (20%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHA-----KRTYRELRLLKHM 78 + N S +GSG +G V A K G VA+KKL IH + E+ + + Sbjct: 19 FHNDSLIGSGGFGDVYKAI-LKDGSAVAIKKL-------IHVSGQGDREFMAEMETIGKI 70 Query: 79 KHENVIGLLDV------------FTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDH 126 KH N++ LL F SLE DV G LN + + Sbjct: 71 KHRNLVPLLGYCKVGDERLLVYEFMKYGSLE---DVLHDPKKAGVKLNWSTRRK------ 121 Query: 127 VQFLIYQILRGLKYIH---SADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDE 178 + RGL ++H S IIHRD+K SN+ ++E+ E ++ DFG+AR T Sbjct: 122 ---IAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLS 178 Query: 179 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGR 220 ++ T Y PE ++ + D++S G ++ ELLTG+ Sbjct: 179 VSTLAGTPGYVPPEYYQSF-RCSTKGDVYSYGVVLLELLTGK 219 >4PDO-A nrPDB Length = 299 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 52/205 (25%), Positives = 96/205 (46%), Gaps = 27/205 (13%) Query: 30 VGSGAYGSVCAA-FDTKTGLR---VAVKKLSRPFQSIIHAKRT--YRELRLLKHMKHENV 83 +G+G +G V T +G + VA+K L + +R E ++ H N+ Sbjct: 42 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGY---TEKQRVDFLGEAGIMGQFSHHNI 98 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQF--LIYQILRGLKY 140 I L V + ++ + ++T M L+ ++ + +Q ++ I G+KY Sbjct: 99 IRLEGV------ISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKY 152 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYRAPEI 193 + + + +HRDL N+ VN + K+ DFGL+R +D+ G + RW APE Sbjct: 153 LANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRW-TAPE- 210 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLT 218 +++ + D+WS G +M E++T Sbjct: 211 AISYRKFTSASDVWSFGIVMWEVMT 235 >3KUL-B nrPDB Length = 325 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/208 (28%), Positives = 92/208 (44%), Gaps = 34/208 (16%) Query: 30 VGSGAYGSVCAAFDTKTGLR---VAVKKLSRPFQSIIHAKRTY-RELRLLKHMKHENVIG 85 +GSG G VC G R VA+K L + +R + E ++ H N+I Sbjct: 57 IGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTE--RQRRDFLSEASIMGQFDHPNIIR 114 Query: 86 LLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQIL-------RG 137 L V T R +VT M L+ ++ T D QF I Q++ G Sbjct: 115 LEGVVTRGRL------AMIVTEYMENGSLDTFLR----THDG-QFTIMQLVGMLRGVGAG 163 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYRA 190 ++Y+ +HRDL N+ V+ + K+ DFGL+R +D+ G + RW A Sbjct: 164 MRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWT-A 222 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLT 218 PE + + ++ D+WS G +M E+L Sbjct: 223 PE-AIAFRTFSSASDVWSFGVVMWEVLA 249 >4AT3-A nrPDB Length = 299 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 92/214 (42%), Gaps = 34/214 (15%) Query: 30 VGSGAYGSVCAA-----FDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVI 84 +G GA+G V A + + VAVK L + K +RE LL +++HE+++ Sbjct: 21 LGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA--RKDFHREAELLTNLQHEHIV 78 Query: 85 GLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ--------------KLTDDHVQFL 130 V L + + ++ DLN ++ +LT + + Sbjct: 79 KFYGVCVEGDPL-----IMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHI 133 Query: 131 IYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTG---YVA 184 QI G+ Y+ S +HRDL N V E+ +KI DFG++R TD G + Sbjct: 134 AQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLP 193 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 RW IM + + D+WS+G ++ E+ T Sbjct: 194 IRWMPPESIM--YRKFTTESDVWSLGVVLWEIFT 225 >4BTK-A nrPDB Length = 337 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 64/235 (27%), Positives = 106/235 (45%), Gaps = 32/235 (13%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR-ELRLLKHM 78 V +R++ L +G G +G + A D T VA+K +S K+ + E+ +LK + Sbjct: 54 VKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-----VESAQQPKQVLKMEVAVLKKL 108 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ---KLTDDHVQFLIYQIL 135 + ++ + F E+FN Y+V L G +L ++ + Q T L QIL Sbjct: 109 QGKDHVCR---FIGCGRNEKFN--YVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQIL 163 Query: 136 RGLKYIHSADIIHRDLKPSNLAVN------EDCELKILDFGLARH----TDD-----EMT 180 ++ IHS +HRD+KPSN A+ C + LDFGLAR T D + Sbjct: 164 ESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYM--LDFGLARQYTNTTGDVRPPRNVA 221 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLI 235 G+ T Y + N + D+WS+ ++ E G+ + +Q+ +I Sbjct: 222 GFRGTVRYASVNAHKN-REMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMI 275 >4NFN-A nrPDB Length = 309 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 64/235 (27%), Positives = 106/235 (45%), Gaps = 32/235 (13%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR-ELRLLKHM 78 V +R++ L +G G +G + A D T VA+K +S K+ + E+ +LK + Sbjct: 19 VKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-----VESAQQPKQVLKMEVAVLKKL 73 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ---KLTDDHVQFLIYQIL 135 + ++ + F E+FN Y+V L G +L ++ + Q T L QIL Sbjct: 74 QGKDHVCR---FIGCGRNEKFN--YVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQIL 128 Query: 136 RGLKYIHSADIIHRDLKPSNLAVN------EDCELKILDFGLARH----TDD-----EMT 180 ++ IHS +HRD+KPSN A+ C + LDFGLAR T D + Sbjct: 129 ESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYM--LDFGLARQYTNTTGDVRPPRNVA 186 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLI 235 G+ T Y + N + D+WS+ ++ E G+ + +Q+ +I Sbjct: 187 GFRGTVRYASVNAHKN-REMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMI 240 >1FVR-A nrPDB Length = 327 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 60/217 (27%), Positives = 95/217 (43%), Gaps = 26/217 (11%) Query: 30 VGSGAYGSVCAAFDTKTGLRV--AVKKLSRPFQSIIHAKRTYRELRLLKHMKHE-NVIGL 86 +G G +G V A K GLR+ A+K++ + + S + EL +L + H N+I L Sbjct: 33 IGEGNFGQVLKARIKKDGLRMDAAIKRM-KEYASKDDHRDFAGELEVLCKLGHHPNIINL 91 Query: 87 LDV------------FTPARSLEEF--NDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIY 132 L + P +L +F L T A N+ L+ + Sbjct: 92 LGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTA--STLSSQQLLHFAA 149 Query: 133 QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD---DEMTGYVATRWYR 189 + RG+ Y+ IHRDL N+ V E+ KI DFGL+R + + G + RW Sbjct: 150 DVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMA 209 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPG 225 LN+ Y D+WS G ++ E+++ G T + G Sbjct: 210 IES--LNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCG 244 >3V5Q-A nrPDB Length = 297 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 58/217 (26%), Positives = 91/217 (41%), Gaps = 37/217 (17%) Query: 30 VGSGAYGSVCAA-----FDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVI 84 +G GA+G V A TK + VAVK L P ++ K RE LL +++HE+++ Sbjct: 23 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDP--TLAARKDFQREAELLTNLQHEHIV 80 Query: 85 GLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ-----------------KLTDDHV 127 V L + + ++ DLN ++ +L + Sbjct: 81 KFYGVCGDGDPL-----IMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQM 135 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTG--- 181 + QI G+ Y+ S +HRDL N V + +KI DFG++R TD G Sbjct: 136 LHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHT 195 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 + RW IM + + D+WS G I+ E+ T Sbjct: 196 MLPIRWMPPESIM--YRKFTTESDVWSFGVILWEIFT 230 >3QD2-B nrPDB Length = 332 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 36/103 (34%), Positives = 56/103 (54%), Gaps = 16/103 (15%) Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE----------- 178 + QI ++++HS ++HRDLKPSN+ D +K+ DFGL D + Sbjct: 169 IFIQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMP 228 Query: 179 ----MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 TG V T+ Y +PE ++ +Y+ VDI+S+G I+ ELL Sbjct: 229 AYATHTGQVGTKLYMSPE-QIHGNNYSHKVDIFSLGLILFELL 270 >4G3E-A nrPDB Length = 352 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 54/202 (26%), Positives = 89/202 (44%), Gaps = 27/202 (13%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 VG G++G V D +TG + AVKK+ + EL + ++ L Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRV-------EELVACAGLSSPRIVPLYGA 134 Query: 90 FTPARSLEEFNDVYLVTHLMGADLNNIVK---CQKLTDDHVQFLIYQILRGLKYIHSADI 146 + F ++ L G L ++K C L +D + + Q L GL+Y+H+ I Sbjct: 135 VREGPWVNIFMEL-----LEGGSLGQLIKQMGC--LPEDRALYYLGQALEGLEYLHTRRI 187 Query: 147 IHRDLKPSNLAVNED-CELKILDFGLARHTDDEMTG-------YV-ATRWYRAPEIMLNW 197 +H D+K N+ ++ D + DFG A + G Y+ T + APE+++ Sbjct: 188 LHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMG- 246 Query: 198 MHYNQTVDIWSVGCIMAELLTG 219 + VDIWS C+M +L G Sbjct: 247 KPCDAKVDIWSSCCMMLHMLNG 268 >6DBM-A nrPDB Length = 318 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 65/225 (28%), Positives = 98/225 (43%), Gaps = 50/225 (22%) Query: 22 ERY-QNLSPVGSGAYGSVCA-AFDTK---TGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 +RY + + +G G +G V +D TG VAVK L + H +E+ +L+ Sbjct: 30 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-KADAGPQHRSGWKQEIDILR 88 Query: 77 HMKHENVIG--------------LLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL 122 + HE++I L+ + P SL + YL H +G Sbjct: 89 TLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRD----YLPRHSIGL----------- 133 Query: 123 TDDHVQFLIY--QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180 Q L++ QI G+ Y+HS IHRDL N+ ++ D +KI DFGLA+ + Sbjct: 134 ----AQLLLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHE 189 Query: 181 GYVATR-------WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 Y WY APE + + Y + D+WS G + ELLT Sbjct: 190 YYRVREDGDSPVFWY-APECLKEYKFYYAS-DVWSFGVTLYELLT 232 >2BUJ-A nrPDB Length = 317 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 33/112 (29%), Positives = 57/112 (50%), Gaps = 14/112 (12%) Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFG----LARHTDD 177 LT+D + +L+ I RGL+ IH+ HRDLKP+N+ + ++ + ++D G H + Sbjct: 131 LTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEG 190 Query: 178 EMTGYVATRW--------YRAPEIMLNWMH--YNQTVDIWSVGCIMAELLTG 219 W YRAPE+ H ++ D+WS+GC++ ++ G Sbjct: 191 SRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFG 242 >4R7H-A nrPDB Length = 343 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 67/245 (27%), Positives = 117/245 (47%), Gaps = 44/245 (17%) Query: 18 WEVPER-YQNLSPVGSGAYGSVCAAFDTKTG-----LRVAVKKLSRPFQSIIHAKRT--- 68 WE P Q +G+GA+G V A G L+VAVK L +S HA Sbjct: 45 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML----KSTAHADEKEAL 100 Query: 69 YRELRLLKHM-KHENVIGLLDVFT---PARSLEEF---NDV--YL---VTHLMGADLNNI 116 EL+++ H+ +HEN++ LL T P + E+ D+ +L ++G L+ Sbjct: 101 MSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPG 160 Query: 117 VKCQKLTDD-----HVQFLIY---QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILD 168 + L + ++ L++ Q+ +G+ ++ S + IHRD+ N+ + KI D Sbjct: 161 QDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGD 220 Query: 169 FGLARHTDDEMTGYVA-------TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GR 220 FGLAR ++ + Y+ +W APE + + ++ Q+ D+WS G ++ E+ + G Sbjct: 221 FGLARDIMND-SNYIVKGNARLPVKWM-APESIFDSVYTVQS-DVWSYGILLWEIFSLGL 277 Query: 221 TLFPG 225 +PG Sbjct: 278 NPYPG 282 >4M66-A nrPDB Length = 325 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 66/260 (25%), Positives = 117/260 (45%), Gaps = 44/260 (16%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E + L VG G +G V A VAVK I+++K+ E++ + ++++E Sbjct: 20 EELKKLEFVGKGGFGVVFRAHHRTWNHDVAVK--------IVNSKKISWEVKAMVNLRNE 71 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTD-DHVQFLIYQILRGLK 139 NV+ LL V T + + LVT M L +++ + + L+ +++ G+ Sbjct: 72 NVLLLLGV-TEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMC 130 Query: 140 YIHSAD--IIHRDLKPSNLAVNEDCELKILDFGLA---------RHTDDEMTGYVATRWY 188 Y+HS D ++HRDLKPSN+ ++ + K+ DFGL+ + T Y Sbjct: 131 YLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAY 190 Query: 189 RAPEIMLNW-MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG------- 240 PE++ + ++ D++S G ++ +L GR + +D+ LI V Sbjct: 191 LDPELLFKVNLKASKASDVYSFGILVWAVLAGRE----AELVDKTSLIRETVCDRQSRPP 246 Query: 241 ----------TPGAELLKKI 250 TPG E LK++ Sbjct: 247 LTELPPGSPETPGLEKLKEL 266 >5L2Q-C nrPDB Length = 320 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 53/201 (26%), Positives = 97/201 (48%), Gaps = 37/201 (18%) Query: 111 ADLNN----IVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC-ELK 165 ADL N ++K ++L++ + Y ++R ++ +H +I+HRDLK N+ +N+ + Sbjct: 135 ADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRIT 194 Query: 166 ILDFGLARH---TDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTL 222 I +F L +H D + + Y +P+++ + + D+W++G ++ +L G+ Sbjct: 195 ITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQ-- 252 Query: 223 FPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAV 282 FP D I Q EL +KI A Y +P+ + + N V Sbjct: 253 FPFYDSIPQ-------------ELFRKI---KAAEYT-----IPE----DGRVSEN--TV 285 Query: 283 DLLEKMLVLDSDKRITAAQAL 303 L+ K+LVLD +R+ AA L Sbjct: 286 CLIRKLLVLDPQQRLAAADVL 306 >3QGY-A nrPDB Length = 286 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 46/204 (22%), Positives = 92/204 (45%), Gaps = 16/204 (7%) Query: 21 PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH 80 P + +GSG +G V + +VA+K + + + E ++ + H Sbjct: 26 PSELTFVQEIGSGQFGLVHLGYWLNKD-KVAIKTIK---EGSMSEDDFIEEAEVMMKLSH 81 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK--LTDDHVQFLIYQILRGL 138 ++ L V LE+ + + L++ ++ Q+ + + + + G+ Sbjct: 82 PKLVQLYGV-----CLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGM 136 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-DDEMTGYVATRW---YRAPEIM 194 Y+ A +IHRDL N V E+ +K+ DFG+ R DD+ T T++ + +PE+ Sbjct: 137 AYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV- 195 Query: 195 LNWMHYNQTVDIWSVGCIMAELLT 218 ++ Y+ D+WS G +M E+ + Sbjct: 196 FSFSRYSSKSDVWSFGVLMWEVFS 219 >4AW2-A nrPDB Length = 437 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 54/214 (25%), Positives = 100/214 (46%), Gaps = 18/214 (8%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR-TYRELRLLKHMKH 80 E ++ L +G GA+G V A K +V K+ ++ + A+ +RE R + Sbjct: 74 EDFEILKVIGRGAFGEV-AVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGD 132 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVT-HLMGADLNNIVKC--QKLTDDHVQFLIYQILRG 137 I L + ++ N++YLV + +G DL ++ +L ++ +F + +++ Sbjct: 133 SKWITTLHY-----AFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIA 187 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFG----LARHTDDEMTGYVATRWYRAPEI 193 + +H +HRD+KP N+ ++ + +++ DFG L + + V T Y +PEI Sbjct: 188 IDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEI 247 Query: 194 ML----NWMHYNQTVDIWSVGCIMAELLTGRTLF 223 + Y D WS+G M E+L G T F Sbjct: 248 LQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPF 281 >4X7Q-B nrPDB Length = 312 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 94/206 (45%), Gaps = 17/206 (8%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSR----PFQSIIHAKRTYRELRLLKHMK----HE 81 +G G +G+V A L+VA+K + R + + + E+ LL + H Sbjct: 39 LGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHP 98 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKY 140 VI LLD F +E + L L DL + I + L + + Q++ +++ Sbjct: 99 GVIRLLDWF----ETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQH 154 Query: 141 IHSADIIHRDLKPSNLAVN--EDCELKILDFGLARHTDDE-MTGYVATRWYRAPEIMLNW 197 HS ++HRD+K N+ ++ C K++DFG DE T + TR Y PE + Sbjct: 155 CHSRGVVHRDIKDENILIDLRRGCA-KLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRH 213 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLF 223 ++ +WS+G ++ +++ G F Sbjct: 214 QYHALPATVWSLGILLYDMVCGDIPF 239 >6FER-A nrPDB Length = 309 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 40/166 (24%), Positives = 76/166 (45%), Gaps = 24/166 (14%) Query: 70 RELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK----------- 118 +E++++ +K N+I LL V L + ++ DLN + Sbjct: 72 KEIKIMSRLKDPNIIHLLAVCITDDPL-----CMITEYMENGDLNQFLSRHEPPNSSSSD 126 Query: 119 CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTD 176 + ++ +++F+ QI G+KY+ S + +HRDL N V ++ +KI DFG++R ++ Sbjct: 127 VRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSG 186 Query: 177 D----EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 D + + RW I+L + D+W+ G + E T Sbjct: 187 DYYRIQGRAVLPIRWMSWESILLG--KFTTASDVWAFGVTLWETFT 230 >5WNO-A nrPDB Length = 330 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 58/223 (26%), Positives = 104/223 (46%), Gaps = 40/223 (17%) Query: 30 VGSGAYGSVCAA-FDTKTGLRVAVKKLSRPFQS--------IIHAKRTYRE-----LRLL 75 +G+GA+G+V A + K V + + FQ+ + A +R L+++ Sbjct: 30 LGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKII 89 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQIL 135 H++ + ++ ++ P +L+ F + L +GA ++ C YQI Sbjct: 90 GFCMHDDGLKIVTIYRPLGNLQNF--LKLHKENLGAR-EQVLYC------------YQIA 134 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA---RHTDDEMT---GYVATRWYR 189 G++Y+ ++HRDL N+ V + ++I DFGL+ +H D +T G VA +W Sbjct: 135 SGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWL- 193 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPG--TDHI 229 A EI Y D+W+ G E++T G++ + G TD I Sbjct: 194 AIEIFSKHC-YTHASDVWAFGVTCWEIITFGQSPYQGMSTDSI 235 >5FM2-A nrPDB Length = 355 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 57/245 (23%), Positives = 101/245 (41%), Gaps = 44/245 (17%) Query: 18 WEVPERYQNLSP-VGSGAYGSVCAA----FDTKTGLRVAVKKLSRPFQSIIHAKRTYREL 72 WE P + L +G G +G V A + G K+ + S + E Sbjct: 59 WEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEF 118 Query: 73 RLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK----------- 121 +LK + H +VI L + L + +V + L ++ + Sbjct: 119 NVLKQVNHPHVIKLYGACSQDGPL-----LLIVEYAKYGSLRGFLRESRKVGPGYLGSGG 173 Query: 122 --------------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKIL 167 LT + +QI +G++Y+ ++HRDL N+ V E ++KI Sbjct: 174 SRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKIS 233 Query: 168 DFGLARHTDDEMT------GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GR 220 DFGL+R +E + G + +W A E + + ++ Q+ D+WS G ++ E++T G Sbjct: 234 DFGLSRDVYEEDSYVKRSQGRIPVKWM-AIESLFDHIYTTQS-DVWSFGVLLWEIVTLGG 291 Query: 221 TLFPG 225 +PG Sbjct: 292 NPYPG 296 >3PP0-A nrPDB Length = 338 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 56/201 (27%), Positives = 87/201 (43%), Gaps = 21/201 (10%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVK---KLSRPFQSIIHAKRTYRELRLLKHMKHENVIGL 86 +GSGA+G+V G V + K+ R S K E ++ + V L Sbjct: 25 LGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRL 84 Query: 87 LDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQ-KLTDDHVQFLIYQILRGLKYIHS 143 L + + V LVT LM G L+++ + + +L + QI +G+ Y+ Sbjct: 85 LGICLTS-------TVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLED 137 Query: 144 ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT------GYVATRWYRAPEIMLNW 197 ++HRDL N+ V +KI DFGLAR D + T G V +W I+ Sbjct: 138 VRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRR- 196 Query: 198 MHYNQTVDIWSVGCIMAELLT 218 + D+WS G + EL+T Sbjct: 197 -RFTHQSDVWSYGVTVWELMT 216 >3QUP-A nrPDB Length = 323 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 56/235 (23%), Positives = 105/235 (44%), Gaps = 31/235 (13%) Query: 20 VPERYQNLSP-VGSGAYGSVCAAF---DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLL 75 +PE+ L +G G +GSV A + + ++VAVK L + + RE + Sbjct: 20 IPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACM 79 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQKLTDDHVQFLIYQI 134 K H +V L+ V +R+ ++ M DL+ + ++ ++ + + Sbjct: 80 KEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTL 139 Query: 135 LR-------GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW 187 +R G++Y+ S + IHRDL N + ED + + DFGL+R + + Sbjct: 140 VRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKI-------YSGDY 192 Query: 188 YR---APEIMLNWMH--------YNQTVDIWSVGCIMAELLT-GRTLFPGTDHID 230 YR A ++ + W+ Y D+W+ G M E++T G+T + G ++ + Sbjct: 193 YRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAE 247 >3LZB-A nrPDB Length = 327 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 99/208 (47%), Gaps = 23/208 (11%) Query: 24 YQNLSPVGSGAYGSVCAAF----DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 ++ + +GSGA+G+V K + VA+K+L R S K E ++ + Sbjct: 17 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASVD 75 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQ-KLTDDHVQFLIYQILR 136 + +V LL + + V L+T LM G L+ + + + + ++ QI + Sbjct: 76 NPHVCRLLGICLTS-------TVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAK 128 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT------GYVATRWYRA 190 G+ Y+ ++HRDL N+ V +KI DFGLA+ E G V +W A Sbjct: 129 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM-A 187 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLT 218 E +L+ ++ +Q+ D+WS G + EL+T Sbjct: 188 LESILHRIYTHQS-DVWSYGVTVWELMT 214 >4YFF-A nrPDB Length = 311 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 93/207 (44%), Gaps = 23/207 (11%) Query: 30 VGSGAYGSVCAAFDTKTGLR---VAVKKL-SRPFQSIIHAKRTYRELRLLKHMKHENVIG 85 +GSG++G V K R VA+K+ + + S RE+ +L + H VI Sbjct: 50 IGSGSFGKV-----YKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQ 104 Query: 86 LLDVFTPARSLEEFNDVYLVT-HLMGADLNNIVKCQKLTDDHVQFLI--YQILRGLKYIH 142 + L + + +VT ++ G L +++ QK D LI + +G++Y+H Sbjct: 105 FV-----GACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLH 159 Query: 143 --SADIIHRDLKPSNLAVNEDCELKILDFGLARHT----DDEMTGYVATRWYRAPEIMLN 196 + IIHRDL N+ + ED + DFG +R +D MT + APE+ Sbjct: 160 NLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQ 219 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLF 223 Y D++S + E+LTG F Sbjct: 220 CTRYTIKADVFSYALCLWEILTGEIPF 246 >4OLI-A nrPDB Length = 645 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 64/225 (28%), Positives = 98/225 (43%), Gaps = 50/225 (22%) Query: 22 ERY-QNLSPVGSGAYGSVCA-AFDTK---TGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 +RY + + +G G +G V +D TG VAVK L + H +E+ +L+ Sbjct: 352 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-KADCGPQHRSGWKQEIDILR 410 Query: 77 HMKHENVIG--------------LLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL 122 + HE++I L+ + P SL + YL H +G Sbjct: 411 TLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRD----YLPRHSIGL----------- 455 Query: 123 TDDHVQFLIY--QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180 Q L++ QI G+ Y+HS IHR+L N+ ++ D +KI DFGLA+ + Sbjct: 456 ----AQLLLFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHE 511 Query: 181 GYVATR-------WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 Y WY APE + + Y + D+WS G + ELLT Sbjct: 512 YYRVREDGDSPVFWY-APECLKEYKFYYAS-DVWSFGVTLYELLT 554 >6J5U-C nrPDB Length = 426 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 62/233 (26%), Positives = 105/233 (45%), Gaps = 31/233 (13%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKT---------GLRVAVKKLSRPFQSIIHAKRTYRELR 73 R NL +G G +G V + +T G+ VAVK+L +P + K E+ Sbjct: 87 RQDNL--LGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQL-KP-EGFQGHKEWLTEVN 142 Query: 74 LLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVK--CQKLTDDHVQF 129 L + H N++ L+ E + LV M G+ N++ + Q LT Sbjct: 143 YLGQLSHPNLVLLVGY------CAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMK 196 Query: 130 LIYQILRGLKYIHSA--DIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEM---TGY 182 + +GL ++H A +I+RD K +N+ ++ D K+ DFGLA+ T D T Sbjct: 197 VAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKV 256 Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLI 235 + T Y APE + D++S G ++ EL++GR ++ ++ L+ Sbjct: 257 IGTHGYAAPEYVATG-RLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLV 308 >5FQD-C nrPDB Length = 341 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 48/166 (28%), Positives = 86/166 (51%), Gaps = 14/166 (8%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 V +Y+ + +GSG++G + A + G VAVK S Q H + Y E +L K + Sbjct: 17 VGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLES---QKARHPQLLY-ESKLYKIL- 71 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIYQILRG 137 + +G+ + + +++N LV L+G L ++ ++ T V L Q++ Sbjct: 72 -QGGVGIPHIRWYGQE-KDYN--VLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISR 127 Query: 138 LKYIHSADIIHRDLKPSN--LAVNEDC-ELKILDFGLARHTDDEMT 180 ++Y+H+ + IHRD+KP N + + C +L ++DFGLA+ D T Sbjct: 128 IEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRT 173 >3HNG-A nrPDB Length = 360 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 36/117 (30%), Positives = 66/117 (56%), Gaps = 11/117 (9%) Query: 132 YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVATRW-- 187 +Q+ RG++++ S IHRDL N+ ++E+ +KI DFGLAR + + + TR Sbjct: 206 FQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPL 265 Query: 188 -YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT----DHIDQLKLILRL 238 + APE + + + Y+ D+WS G ++ E+ + G + +PG D +L+ +R+ Sbjct: 266 KWMAPESIFDKI-YSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRM 321 >4JLC-A nrPDB Length = 657 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 60/230 (26%), Positives = 92/230 (40%), Gaps = 59/230 (25%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLS-----RPFQSIIHAKRTYRELRLLKHMKHENVI 84 +G GA +V KTG AVK + RP + RE +LK + H+N++ Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 69 Query: 85 GLLDV--------------FTPARSL----EEFNDVYLVTHLMGADLNNIVKCQKLTDDH 126 L + F P SL EE ++ Y L + Sbjct: 70 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAY-----------------GLPESE 112 Query: 127 VQFLIYQILRGLKYIHSADIIHRDLKPSNL--AVNEDCE--LKILDFGLARHT--DDEMT 180 ++ ++ G+ ++ I+HRD+KP N+ + ED + K+ DFG AR D++ Sbjct: 113 FLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV 172 Query: 181 GYVATRWYRAPEI----MLNWMH---YNQTVDIWSVGCIMAELLTGRTLF 223 T Y P++ +L H Y TVD+WSVG TG F Sbjct: 173 SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPF 222 >3VHK-A nrPDB Length = 368 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 35/112 (31%), Positives = 64/112 (57%), Gaps = 9/112 (8%) Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179 LT +H+ +Q+ +G++++ S IHRDL N+ ++E +KI DFGLAR + D + Sbjct: 197 LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDY 256 Query: 180 T----GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT 226 + +W APE + + ++ Q+ D+WS G ++ E+ + G + +PG Sbjct: 257 VRKGDARLPLKWM-APETIFDRVYTIQS-DVWSFGVLLWEIFSLGASPYPGV 306 >5KMM-A nrPDB Length = 329 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 93/217 (42%), Gaps = 38/217 (17%) Query: 30 VGSGAYGSVCAA-----FDTKTGLRVAVKKLSRPFQSIIHAKRTY-RELRLLKHMKHENV 83 +G GA+G V A + + VAVK L +S A++ + RE LL ++H+++ Sbjct: 43 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASES---ARQDFQREAELLTMLQHQHI 99 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK----------------LTDDHV 127 + V T R L + + ++ DLN ++ L + Sbjct: 100 VRFFGVCTEGRPL-----LMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQL 154 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTG--- 181 + Q+ G+ Y+ +HRDL N V + +KI DFG++R TD G Sbjct: 155 LAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT 214 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 + RW PE +L + + D+WS G ++ E+ T Sbjct: 215 MLPIRWM-PPESIL-YRKFTTESDVWSFGVVLWEIFT 249 >4E20-A nrPDB Length = 290 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 62/225 (27%), Positives = 96/225 (42%), Gaps = 50/225 (22%) Query: 22 ERY-QNLSPVGSGAYGSVCA-AFDTK---TGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 +RY + + +G G +G V +D TG VAVK L + + RE+ +L+ Sbjct: 7 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQ-REIEILR 65 Query: 77 HMKHENVIG--------------LLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL 122 + HE+++ L+ + P SL + YL H +G Sbjct: 66 TLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRD----YLPRHCVGL----------- 110 Query: 123 TDDHVQFLIY--QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180 Q L++ QI G+ Y+H+ IHR L N+ ++ D +KI DFGLA+ + Sbjct: 111 ----AQLLLFAQQICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHE 166 Query: 181 GYVATR-------WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 Y WY APE + Y + D+WS G + ELLT Sbjct: 167 YYRVREDGDSPVFWY-APECLKECKFYYAS-DVWSFGVTLYELLT 209 >6FEX-A nrPDB Length = 321 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 48/190 (25%), Positives = 82/190 (43%), Gaps = 28/190 (14%) Query: 48 LRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTH 107 L VAVK L RP + +E++++ +K N+I LL V L D + Sbjct: 58 LLVAVKIL-RPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITD-----Y 111 Query: 108 LMGADLNNIVKCQKLTDDHVQ--------------FLIYQILRGLKYIHSADIIHRDLKP 153 + DLN + +L D + + QI G++Y+ + + +HRDL Sbjct: 112 MENGDLNQFLSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLAT 171 Query: 154 SNLAVNEDCELKILDFGLAR--HTDD----EMTGYVATRWYRAPEIMLNWMHYNQTVDIW 207 N V E+ +KI DFG++R + D + + RW I++ + D+W Sbjct: 172 RNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMG--KFTTASDVW 229 Query: 208 SVGCIMAELL 217 + G + E+L Sbjct: 230 AFGVTLWEVL 239 >6GVJ-A nrPDB Length = 429 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 40/138 (28%), Positives = 65/138 (47%), Gaps = 17/138 (12%) Query: 102 VYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQ-ILRGLKYIHSADIIHRDLKPSNLAVNE 160 +Y+V DLN+ +K +K D + ++ +L + IH I+H DLKP+N + Sbjct: 219 IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-V 277 Query: 161 DCELKILDFGLARHTDDEMTGY-----VATRWYRAPEIMLNWMHYNQT----------VD 205 D LK++DFG+A + T V T Y PE + + + D Sbjct: 278 DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSD 337 Query: 206 IWSVGCIMAELLTGRTLF 223 +WS+GCI+ + G+T F Sbjct: 338 VWSLGCILYYMTYGKTPF 355 >3Q4U-A nrPDB Length = 301 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 60/214 (28%), Positives = 96/214 (44%), Gaps = 34/214 (15%) Query: 27 LSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH--MKHENVI 84 L VG G YG V + G VAVK S + K +RE L ++HEN++ Sbjct: 13 LECVGKGRYGEVWRG--SWQGENVAVKIFSSRDE-----KSWFRETELYNTVMLRHENIL 65 Query: 85 GLLDVFTPARSLEEFNDVYLVTHL--MGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIH 142 G + + S ++L+TH MG+ L + ++ L ++ I GL ++H Sbjct: 66 GF--IASDMTSRHSSTQLWLITHYHEMGS-LYDYLQLTTLDTVSCLRIVLSIASGLAHLH 122 Query: 143 --------SADIIHRDLKPSNLAVNEDCELKILDFGLA----RHTDDEMTG---YVATRW 187 I HRDLK N+ V ++ + I D GLA + T+ G V T+ Sbjct: 123 IEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKR 182 Query: 188 YRAPEIM-----LNWMHYNQTVDIWSVGCIMAEL 216 Y APE++ ++ + VDIW+ G ++ E+ Sbjct: 183 YMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEV 216 >5GNK-A nrPDB Length = 297 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 98/208 (47%), Gaps = 23/208 (11%) Query: 24 YQNLSPVGSGAYGSVCAAF----DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 ++ + +GSGA+G+V K + VA+K+L R S K E ++ + Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASVD 79 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQ-KLTDDHVQFLIYQILR 136 + +V LL + + V L+ LM G L+ + + + + ++ QI + Sbjct: 80 NPHVCRLLGICLTS-------TVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAK 132 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT------GYVATRWYRA 190 G+ Y+ ++HRDL N+ V +KI DFGLA+ E G V +W A Sbjct: 133 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM-A 191 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLT 218 E +L+ ++ +Q+ D+WS G + EL+T Sbjct: 192 LESILHRIYTHQS-DVWSYGVTVWELMT 218 >1U59-A nrPDB Length = 287 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 51/201 (25%), Positives = 95/201 (47%), Gaps = 22/201 (10%) Query: 30 VGSGAYGSVCAAFDT--KTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLL 87 +G G +GSV K + VA+K L + + + RE +++ + + ++ L+ Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA-DTEEMMREAQIMHQLDNPYIVRLI 76 Query: 88 DVFTPARSLEEFNDVYLVTHLMGAD-LNNIV--KCQKLTDDHVQFLIYQILRGLKYIHSA 144 V + + LV + G L+ + K +++ +V L++Q+ G+KY+ Sbjct: 77 GVC-------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 129 Query: 145 DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVAT-------RWYRAPEIMLNW 197 + +HRDL N+ + KI DFGL++ + + Y A +WY APE +N+ Sbjct: 130 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APEC-INF 187 Query: 198 MHYNQTVDIWSVGCIMAELLT 218 ++ D+WS G M E L+ Sbjct: 188 RKFSSRSDVWSYGVTMWEALS 208 >3M42-A nrPDB Length = 299 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 52/203 (25%), Positives = 90/203 (44%), Gaps = 39/203 (19%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRL-LKHMKHENVIGLLD 88 +G G G V F+ +T + A+K L + RE+ L + + +++ ++D Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 78 Query: 89 VFTPARSLEEFNDVYLVTH--LMGADLNNIVKC---QKLTDDHVQFLIYQILRGLKYIHS 143 V+ +L L+ L G +L + ++ Q T+ ++ I ++Y+HS Sbjct: 79 VY---ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 135 Query: 144 ADIIHRDLKPSNL---AVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHY 200 +I HRD+KP NL + + LK+ DFG A+ T E Y Sbjct: 136 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGE--------------------KY 175 Query: 201 NQTVDIWSVGCIMAELLTGRTLF 223 +++ D+WS+G IM LL G F Sbjct: 176 DKSCDMWSLGVIMYILLCGYPPF 198 >5U6C-A nrPDB Length = 315 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 54/222 (24%), Positives = 94/222 (42%), Gaps = 31/222 (13%) Query: 30 VGSGAYGSVCAAF---DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGL 86 +G G +GSV + T L+VAVK + S + E +K H NV+ L Sbjct: 44 LGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVMRL 103 Query: 87 LDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDD--HV------QFLIYQILRGL 138 L V S + ++ + DL+ + +L H+ +F++ I G+ Sbjct: 104 LGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMV-DIALGM 162 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIM---L 195 +Y+ + + +HRDL N + +D + + DFGL++ + +YR I + Sbjct: 163 EYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKI-------YSGDYYRQGRIAKMPV 215 Query: 196 NWMH--------YNQTVDIWSVGCIMAELLT-GRTLFPGTDH 228 W+ Y D+W+ G M E+ T G T +PG + Sbjct: 216 KWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQN 257 >4FL3-A nrPDB Length = 635 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 30/104 (28%), Positives = 55/104 (52%), Gaps = 9/104 (8%) Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-------H 174 + D ++ L++Q+ G+KY+ ++ +HRDL N+ + KI DFGL++ + Sbjct: 466 VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENY 525 Query: 175 TDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 + G +WY APE +N+ ++ D+WS G +M E + Sbjct: 526 YKAQTHGKWPVKWY-APEC-INYYKFSSKSDVWSFGVLMWEAFS 567 >4EUT-A nrPDB Length = 396 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 57/226 (25%), Positives = 90/226 (39%), Gaps = 51/226 (22%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLS-----RPFQSIIHAKRTYRELRLLKHMKHENVI 84 +G GA +V KTG A+K + RP + RE +LK + H+N++ Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 70 Query: 85 GLLDV--------------FTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL 130 L + F P SL Y V L L + + Sbjct: 71 KLFAIEEETTTRHKVLIMEFCPCGSL------YTV-------LEEPSNAYGLPESEFLIV 117 Query: 131 IYQILRGLKYIHSADIIHRDLKPSNL--AVNEDCE--LKILDFGLARHT--DDEMTGYVA 184 + ++ G+ ++ I+HR++KP N+ + ED + K+ DFG AR D++ Sbjct: 118 LRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYG 177 Query: 185 TRWYRAPEI----MLNWMH---YNQTVDIWSVGCIMAELLTGRTLF 223 T Y P++ +L H Y TVD+WS+G TG F Sbjct: 178 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 223 >3HMP-A nrPDB Length = 342 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 40/138 (28%), Positives = 65/138 (47%), Gaps = 17/138 (12%) Query: 102 VYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQ-ILRGLKYIHSADIIHRDLKPSNLAVNE 160 +Y+V DLN+ +K +K D + ++ +L + IH I+H DLKP+N + Sbjct: 131 IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-V 189 Query: 161 DCELKILDFGLARHTDDEMTGY-----VATRWYRAPEIMLNWMHYNQT----------VD 205 D LK++DFG+A + T V T Y PE + + + D Sbjct: 190 DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSD 249 Query: 206 IWSVGCIMAELLTGRTLF 223 +WS+GCI+ + G+T F Sbjct: 250 VWSLGCILYYMTYGKTPF 267 >4EUU-A nrPDB Length = 319 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 57/226 (25%), Positives = 90/226 (39%), Gaps = 51/226 (22%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLS-----RPFQSIIHAKRTYRELRLLKHMKHENVI 84 +G GA +V KTG A+K + RP + RE +LK + H+N++ Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 70 Query: 85 GLLDV--------------FTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL 130 L + F P SL Y V L L + + Sbjct: 71 KLFAIEEETTTRHKVLIMEFCPCGSL------YTV-------LEEPSNAYGLPESEFLIV 117 Query: 131 IYQILRGLKYIHSADIIHRDLKPSNL--AVNEDCE--LKILDFGLAR--HTDDEMTGYVA 184 + ++ G+ ++ I+HR++KP N+ + ED + K+ DFG AR D++ Sbjct: 118 LRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYG 177 Query: 185 TRWYRAPEI----MLNWMH---YNQTVDIWSVGCIMAELLTGRTLF 223 T Y P++ +L H Y TVD+WS+G TG F Sbjct: 178 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 223 >4C59-A nrPDB Length = 340 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 53/210 (25%), Positives = 91/210 (43%), Gaps = 28/210 (13%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-HENVIGLLD 88 + G + V A D +G A+K+L + A +E+ +K + H N++ Sbjct: 35 LAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRA--IIQEVCFMKKLSGHPNIVQFCS 92 Query: 89 VFTPARSLEEFN--DVYLVTHLMGADLNNIVKCQK----LTDDHVQFLIYQILRGLKYIH 142 + + + + L+T L L +K + L+ D V + YQ R ++++H Sbjct: 93 AASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMH 152 Query: 143 SAD--IIHRDLKPSNLAVNEDCELKILDFGLA---------------RHTDDEMTGYVAT 185 IIHRDLK NL ++ +K+ DFG A R +E T Sbjct: 153 RQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTT 212 Query: 186 RWYRAPEIMLNWMHY--NQTVDIWSVGCIM 213 YR PEI+ + ++ + DIW++GCI+ Sbjct: 213 PMYRTPEIIDLYSNFPIGEKQDIWALGCIL 242 >6NT9-A nrPDB Length = 742 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 57/230 (24%), Positives = 92/230 (40%), Gaps = 59/230 (25%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLS-----RPFQSIIHAKRTYRELRLLKHMKHENVI 84 +G GA +V KTG A+K + RP + RE +LK + H+N++ Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 68 Query: 85 GLLDV--------------FTPARSL----EEFNDVYLVTHLMGADLNNIVKCQKLTDDH 126 L + F P SL EE ++ Y L + Sbjct: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAY-----------------GLPESE 111 Query: 127 VQFLIYQILRGLKYIHSADIIHRDLKPSNL--AVNEDCE--LKILDFGLARHT--DDEMT 180 ++ ++ G+ ++ I+HR++KP N+ + ED + K+ DFG AR D++ Sbjct: 112 FLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV 171 Query: 181 GYVATRWYRAPEI----MLNWMH---YNQTVDIWSVGCIMAELLTGRTLF 223 T Y P++ +L H Y TVD+WS+G TG F Sbjct: 172 SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 >3SOC-A nrPDB Length = 322 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 53/197 (26%), Positives = 94/197 (47%), Gaps = 27/197 (13%) Query: 50 VAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVT--H 107 VAVK P Q + Y E+ L MKHEN++ + S++ D++L+T H Sbjct: 50 VAVKIF--PIQDKQSWQNEY-EVYSLPGMKHENILQFIGAEKRGTSVD--VDLWLITAFH 104 Query: 108 LMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIH----------SADIIHRDLKPSNLA 157 G+ L++ +K ++ + + + + RGL Y+H I HRD+K N+ Sbjct: 105 EKGS-LSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVL 163 Query: 158 VNEDCELKILDFGL-----ARHTDDEMTGYVATRWYRAPEIMLNWMHYNQ----TVDIWS 208 + + I DFGL A + + G V TR Y APE++ +++ + +D+++ Sbjct: 164 LKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYA 223 Query: 209 VGCIMAELLTGRTLFPG 225 +G ++ EL + T G Sbjct: 224 MGLVLWELASRCTAADG 240 >2OZO-A nrPDB Length = 613 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 49/201 (24%), Positives = 94/201 (46%), Gaps = 22/201 (10%) Query: 30 VGSGAYGSVCAAFDT--KTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLL 87 +G G +GSV K + VA+K L + + + RE +++ + + ++ L+ Sbjct: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA-DTEEMMREAQIMHQLDNPYIVRLI 402 Query: 88 DVFTPARSLEEFNDVYLVTHLMGADLNN---IVKCQKLTDDHVQFLIYQILRGLKYIHSA 144 V + + LV + G + + K +++ +V L++Q+ G+KY+ Sbjct: 403 GVC-------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 455 Query: 145 DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVAT-------RWYRAPEIMLNW 197 + +HR+L N+ + KI DFGL++ + + Y A +WY APE +N+ Sbjct: 456 NFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APEC-INF 513 Query: 198 MHYNQTVDIWSVGCIMAELLT 218 ++ D+WS G M E L+ Sbjct: 514 RKFSSRSDVWSYGVTMWEALS 534 >5C26-A nrPDB Length = 299 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 33/112 (29%), Positives = 59/112 (52%), Gaps = 10/112 (8%) Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG 181 + D ++ L++Q+ G+KY+ ++ +HRDL N+ + KI DFGL++ + Sbjct: 124 VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENY 183 Query: 182 YVA-------TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPG 225 Y A +WY APE +N+ ++ D+WS G +M E + G+ + G Sbjct: 184 YKAQTHGKWPVKWY-APEC-INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 233 >3BBT-B nrPDB Length = 328 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 54/204 (26%), Positives = 86/204 (42%), Gaps = 27/204 (13%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR---ELRLLKHMKHENVIGL 86 +GSGA+G+V G V + + K E ++ M H +++ L Sbjct: 23 LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRL 82 Query: 87 LDV-FTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQF-LIYQILRGLKYIH 142 L V +P + LVT LM G L + + + + QI +G+ Y+ Sbjct: 83 LGVCLSPT--------IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLE 134 Query: 143 SADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWM---- 198 ++HRDL N+ V +KI DFGLAR + + Y A ++ + WM Sbjct: 135 ERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNAD----GGKMPIKWMALEC 190 Query: 199 -HYNQTV---DIWSVGCIMAELLT 218 HY + D+WS G + EL+T Sbjct: 191 IHYRKFTHQSDVWSYGVTIWELMT 214 >5AP3-A nrPDB Length = 313 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 40/138 (28%), Positives = 64/138 (46%), Gaps = 17/138 (12%) Query: 102 VYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQ-ILRGLKYIHSADIIHRDLKPSNLAVNE 160 +Y+V DLN +K +K D + ++ +L + IH I+H DLKP+N + Sbjct: 103 IYMVMECGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-V 161 Query: 161 DCELKILDFGLARHTDDEMTGY-----VATRWYRAPEIMLNWMHYNQT----------VD 205 D LK++DFG+A + T V T Y PE + + + D Sbjct: 162 DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSD 221 Query: 206 IWSVGCIMAELLTGRTLF 223 +WS+GCI+ + G+T F Sbjct: 222 VWSLGCILYYMTYGKTPF 239 >6BSD-A nrPDB Length = 876 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 48/196 (24%), Positives = 82/196 (41%), Gaps = 34/196 (17%) Query: 48 LRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTH 107 L VAVK L RP + +E++++ +K N+I LL V L D + Sbjct: 613 LLVAVKIL-RPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITD-----Y 666 Query: 108 LMGADLNNIVKCQKLTDDHVQ--------------------FLIYQILRGLKYIHSADII 147 + DLN + +L D + + QI G++Y+ + + + Sbjct: 667 MENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFV 726 Query: 148 HRDLKPSNLAVNEDCELKILDFGLAR--HTDD----EMTGYVATRWYRAPEIMLNWMHYN 201 HRDL N V E+ +KI DFG++R + D + + RW I++ + Sbjct: 727 HRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMG--KFT 784 Query: 202 QTVDIWSVGCIMAELL 217 D+W+ G + E+L Sbjct: 785 TASDVWAFGVTLWEVL 800 >4F0G-A nrPDB Length = 287 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 53/208 (25%), Positives = 97/208 (46%), Gaps = 20/208 (9%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKL----SRPFQSIIHAKRTY-RELRLLKHMKHENVI 84 +G G +G V K VA+K L S +I + + RE+ ++ ++ H N++ Sbjct: 27 IGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPNIV 86 Query: 85 GLLDVF-TPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS 143 L + P R + EF + H + + I KL L+ I G++Y+ + Sbjct: 87 KLYGLMHNPPRMVMEFVPCGDLYHRLLDKAHPIKWSVKLR------LMLDIALGIEYMQN 140 Query: 144 AD--IIHRDLKPSNL---AVNEDCEL--KILDFGLARHTDDEMTGYVATRWYRAPE-IML 195 + I+HRDL+ N+ +++E+ + K+ DFGL++ + ++G + + APE I Sbjct: 141 QNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVSGLLGNFQWMAPETIGA 200 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLF 223 Y + D +S I+ +LTG F Sbjct: 201 EEESYTEKADTYSFAMILYTILTGEGPF 228 >2ZMD-A nrPDB Length = 390 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 39/138 (28%), Positives = 64/138 (46%), Gaps = 17/138 (12%) Query: 102 VYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQ-ILRGLKYIHSADIIHRDLKPSNLAVNE 160 +Y+V DLN+ +K +K D + ++ +L + IH I+H DLKP+N + Sbjct: 131 IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-V 189 Query: 161 DCELKILDFGLARHTDDEMTGYVATRW-----YRAPEIMLNWMHYNQT----------VD 205 D LK++DFG+A + T V Y PE + + + D Sbjct: 190 DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSSSRENGKSKSKISPKSD 249 Query: 206 IWSVGCIMAELLTGRTLF 223 +WS+GCI+ + G+T F Sbjct: 250 VWSLGCILYYMTYGKTPF 267 >6O8B-A nrPDB Length = 665 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 57/230 (24%), Positives = 92/230 (40%), Gaps = 59/230 (25%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLS-----RPFQSIIHAKRTYRELRLLKHMKHENVI 84 +G GA +V KTG A+K + RP + RE +LK + H+N++ Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 76 Query: 85 GLLDV--------------FTPARSL----EEFNDVYLVTHLMGADLNNIVKCQKLTDDH 126 L + F P SL EE ++ Y L + Sbjct: 77 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAY-----------------GLPESE 119 Query: 127 VQFLIYQILRGLKYIHSADIIHRDLKPSNL--AVNEDCE--LKILDFGLARHT--DDEMT 180 ++ ++ G+ ++ I+HR++KP N+ + ED + K+ DFG AR D++ Sbjct: 120 FLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV 179 Query: 181 GYVATRWYRAPEI----MLNWMH---YNQTVDIWSVGCIMAELLTGRTLF 223 T Y P++ +L H Y TVD+WS+G TG F Sbjct: 180 ELYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 229 >2QLU-A nrPDB Length = 314 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 45/174 (25%), Positives = 85/174 (48%), Gaps = 25/174 (14%) Query: 67 RTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVT--HLMGADLNNIVKCQKLTD 124 ++ RE+ MKHEN++ + +LE +++L+T H G+ L + +K +T Sbjct: 55 QSEREIFSTPGMKHENLLQFIAAEKRGSNLE--VELWLITAFHDKGS-LTDYLKGNIITW 111 Query: 125 DHVQFLIYQILRGLKYIH-----------SADIIHRDLKPSNLAVNEDCELKILDFGLAR 173 + + + + RGL Y+H I HRD K N+ + D + DFGLA Sbjct: 112 NELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAV 171 Query: 174 HTD-----DEMTGYVATRWYRAPEIMLNWMHYNQ----TVDIWSVGCIMAELLT 218 + + G V TR Y APE++ +++ + +D++++G ++ EL++ Sbjct: 172 RFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVS 225 >4LRM-A nrPDB Length = 334 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 99/211 (46%), Gaps = 26/211 (12%) Query: 24 YQNLSPVGSGAYGSVCAAF----DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM- 78 ++ + +GSGA+G+V K + VA+K+L R S K E ++ + Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASVD 79 Query: 79 --KHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQ-KLTDDHVQFLIYQ 133 + +V LL + + V L+T LM G L+ + + + + ++ Q Sbjct: 80 NPGNPHVCRLLGICLTS-------TVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ 132 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT------GYVATRW 187 I +G+ Y+ ++HRDL N+ V +KI DFGLA+ E G V +W Sbjct: 133 IAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW 192 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 A E +L+ ++ +Q+ D+WS G + EL+T Sbjct: 193 M-ALESILHRIYTHQS-DVWSYGVTVWELMT 221 >2QKW-B nrPDB Length = 321 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 93/202 (46%), Gaps = 19/202 (9%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLS-RPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 +G G +G V + G +VA+K+ + Q I + L +H ++IG D Sbjct: 47 IGHGVFGKVYKGV-LRDGAKVALKRRTPESSQGIEEFETEIETLSFCRHPHLVSLIGFCD 105 Query: 89 ----VFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSA 144 + + +E N L HL G+DL + ++ + + RGL Y+H+ Sbjct: 106 ERNEMILIYKYMENGN---LKRHLYGSDLPTM----SMSWEQRLEICIGAARGLHYLHTR 158 Query: 145 DIIHRDLKPSNLAVNEDCELKILDFGLARHTDD----EMTGYV-ATRWYRAPEIMLNWMH 199 IIHRD+K N+ ++E+ KI DFG+++ + ++ V T Y PE + Sbjct: 159 AIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKG-R 217 Query: 200 YNQTVDIWSVGCIMAELLTGRT 221 + D++S G ++ E+L R+ Sbjct: 218 LTEKSDVYSFGVVLFEVLCARS 239 >3UIM-A nrPDB Length = 326 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 57/209 (27%), Positives = 97/209 (46%), Gaps = 14/209 (6%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 + N + +G G +G V G VAVK+L ++ + E+ ++ H N+ Sbjct: 32 FSNKNILGRGGFGKVYKG-RLADGTLVAVKRLKEE-RTQGGELQFQTEVEMISMAVHRNL 89 Query: 84 IGLLD-VFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTD-DHVQFLIYQILRGLKYI 141 + L TP L + Y+ + + L + Q D Q + RGL Y+ Sbjct: 90 LRLRGFCMTPTERLLVYP--YMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYL 147 Query: 142 HS---ADIIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTGYV-ATRWYRAPEIM 194 H IIHRD+K +N+ ++E+ E + DFGLA+ + D +T V T + APE Sbjct: 148 HDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEY- 206 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLF 223 L+ ++ D++ G ++ EL+TG+ F Sbjct: 207 LSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >3ZBF-A nrPDB Length = 322 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 66/234 (28%), Positives = 105/234 (44%), Gaps = 38/234 (16%) Query: 30 VGSGAYGSVCAA-----FDTKTG-LRVAVKKLSRPFQSIIHAKRTY-RELRLLKHMKHEN 82 +GSGA+G V +G ++VAVK L + S K + +E L+ H N Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKK--GSTDQEKIEFLKEAHLMSKFNHPN 98 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDH--------VQFLIYQ 133 ++ L V L E Y++ LM G DL ++ ++ + + L Sbjct: 99 ILKQLGVCL----LNE--PQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVD 152 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVN-EDCE----LKILDFGLAR------HTDDEMTGY 182 I +G Y+ IHRDL N V+ +D +KI DFGLAR + G Sbjct: 153 ISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGL 212 Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLI 235 + RW APE +++ + Q+ D+WS G ++ E+LT G +P ++D L + Sbjct: 213 LPVRWM-APESLMDGIFTTQS-DVWSFGILIWEILTLGHQPYPAHSNLDVLNYV 264 >2VD5-A nrPDB Length = 412 Score = 54.3 bits (129), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 60/266 (22%), Positives = 111/266 (41%), Gaps = 18/266 (6%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 ++ L +G GA+ V +TG A+K +++ +RE R + Sbjct: 63 FEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRW 122 Query: 84 IGLLDVFTPARSLEEFNDVYLVT-HLMGADLNNIVK--CQKLTDDHVQFLIYQILRGLKY 140 I L + ++ N +YLV + +G DL ++ +++ + +F + +I+ + Sbjct: 123 ITQLHF-----AFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDS 177 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFG--LARHTDDEMTGYVA--TRWYRAPEIM-- 194 +H +HRD+KP N+ ++ +++ DFG L D + VA T Y +PEI+ Sbjct: 178 VHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQA 237 Query: 195 ----LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250 Y D W++G E+ G+T F + I+ L+ + Sbjct: 238 VGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEG 297 Query: 251 SSESARNYIQSLTQMPKMNFANVFIG 276 E AR++IQ L P+ G Sbjct: 298 VPEEARDFIQRLLCPPETRLGRGGAG 323 >3MDY-A nrPDB Length = 337 Score = 54.3 bits (129), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 58/221 (26%), Positives = 97/221 (43%), Gaps = 34/221 (15%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH-- 77 + ++ Q + +G G YG V G +VAVK ++ +RE + + Sbjct: 35 IAKQIQMVKQIGKGRYGEVWMG--KWRGEKVAVKVFFTTEEA-----SWFRETEIYQTVL 87 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVT--HLMGADLNNIVKCQKLTDDHVQFLIYQIL 135 M+HEN++G + + + +YL+T H G+ L + +K L + L Y + Sbjct: 88 MRHENILGF--IAADIKGTGSWTQLYLITDYHENGS-LYDYLKSTTLDAKSMLKLAYSSV 144 Query: 136 RGLKYIHS--------ADIIHRDLKPSNLAVNEDCELKILDFGLA-------RHTDDEMT 180 GL ++H+ I HRDLK N+ V ++ I D GLA D Sbjct: 145 SGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPN 204 Query: 181 GYVATRWYRAPEIM---LNWMHYNQTV--DIWSVGCIMAEL 216 V T+ Y PE++ LN H+ + D++S G I+ E+ Sbjct: 205 TRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEV 245 >4XLV-A nrPDB Length = 328 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 61/226 (26%), Positives = 98/226 (43%), Gaps = 35/226 (15%) Query: 18 WEVP-ERYQNLSPVGSGAYGSV--CAAFDTKTG---LRVAVKKLSRPFQSIIHAKRTYRE 71 WEV E+ L +G G++G V A D G RVAVK ++ S+ E Sbjct: 34 WEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNES-ASLRERIEFLNE 92 Query: 72 LRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADL------------NNIVK 118 ++K +V+ LL V + + +V LM DL NN + Sbjct: 93 ASVMKGFTCHHVVRLLGVVSKGQP------TLVVMELMAHGDLKSYLRSLRPEAENNPGR 146 Query: 119 CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---HT 175 + +Q + +I G+ Y+++ +HRDL N V D +KI DFG+ R T Sbjct: 147 PPPTLQEMIQ-MAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYET 205 Query: 176 D---DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 D G + RW APE + + + + + D+WS G ++ E+ + Sbjct: 206 DYYRKGGKGLLPVRWM-APESLKDGV-FTTSSDMWSFGVVLWEITS 249 >4LQP-A nrPDB Length = 508 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 43/157 (27%), Positives = 77/157 (49%), Gaps = 15/157 (9%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E + + +G GA+G V TG A+K L +S ++ K L H+K E Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTL---LKSEMYKKDQ------LAHVKAE 152 Query: 82 -NVIGLLD---VFTPARSLEEFNDVYLVTHLM-GADLNN-IVKCQKLTDDHVQFLIYQIL 135 +V+ D V + S ++ +YL+ + G DL +++ Q T+D +F + + + Sbjct: 153 RDVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECI 212 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA 172 ++ IH IHR +KP N+ ++ +K+ DFGL+ Sbjct: 213 LAIETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLS 249 Score = 35.4 bits (80), Expect = 0.040, Method: Compositional matrix adjust. Identities = 19/37 (51%), Positives = 21/37 (56%), Gaps = 1/37 (2%) Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTG 219 V T Y APEI L + Y Q D WS+G IM E L G Sbjct: 324 VGTPDYIAPEIFL-YQGYGQECDWWSLGAIMYECLIG 359 >5J0A-A nrPDB Length = 300 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 46/173 (26%), Positives = 82/173 (47%), Gaps = 24/173 (13%) Query: 63 IHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHL-MGAD--LNNIVKC 119 ++ KR E ++LK + H N++G R+ E ND L + G + LN++++ Sbjct: 56 VYQKRLMDEAKILKSLHHPNIVGY-------RAFTEANDGSLCLAMEYGGEKSLNDLIEE 108 Query: 120 Q-KLTDDHVQFLI-----YQILRGLKYIH-SADIIHRDLKPSNLAVNEDCE-LKILDFGL 171 + K + D I + RGLKY+H ++H D+K SN+ + D E +KI D G+ Sbjct: 109 RYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGV 168 Query: 172 ARHTDDEM------TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 + D+ M Y+ T ++ E + DI++ G + E++T Sbjct: 169 SLPLDENMEVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMT 221 >5VC6-A nrPDB Length = 289 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 34/137 (24%), Positives = 62/137 (45%), Gaps = 1/137 (0%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM-KHEN 82 + L +GSG +GSV G A+K+ +P + + RE+ + +H + Sbjct: 13 FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH 72 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIH 142 V+ + + N+ L A N + ++ L+ Q+ RGL+YIH Sbjct: 73 VVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIH 132 Query: 143 SADIIHRDLKPSNLAVN 159 S ++H D+KPSN+ ++ Sbjct: 133 SMSLVHMDIKPSNIFIS 149 >4TN6-A nrPDB Length = 318 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 48/171 (28%), Positives = 77/171 (45%), Gaps = 22/171 (12%) Query: 19 EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVK----KLSRPFQSIIHAKRTYRELRL 74 V RY+ +GSG++G + D G VA+K K P I E ++ Sbjct: 4 RVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHI--------ESKI 55 Query: 75 LKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIY 132 K M+ G + + T E + +V L+G L ++ +K + V L Sbjct: 56 YKMMQ-----GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLAD 110 Query: 133 QILRGLKYIHSADIIHRDLKPSNLAVN---EDCELKILDFGLARHTDDEMT 180 Q++ ++YIHS + IHRD+KP N + + + I+DFGLA+ D T Sbjct: 111 QMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDART 161 >5IKW-A nrPDB Length = 310 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 48/195 (24%), Positives = 88/195 (45%), Gaps = 25/195 (12%) Query: 44 TKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-HENVIGLLDVFTPARSLEEFNDV 102 T G+R A+K++ ++ RE+ ++K + H+N++G LD + S + + Sbjct: 35 THGGIRCALKRMY--VNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVL 92 Query: 103 YLVTHLMGADLNNIVKCQKLTDDHVQFLIYQIL----RGLKYIHSAD--IIHRDLKPSNL 156 L+ + + N + +KL + + QI + +H IIHRDLK N+ Sbjct: 93 ILMEYCRAGQVVNQMN-KKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENI 151 Query: 157 AVNEDCELKILDFGLARH------------TDDEMTGYVATRWYRAPEI--MLNWMHYNQ 202 +N+ + DFG A + ++E+ Y T YRAPE+ + Sbjct: 152 LLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKY-TTLSYRAPEMINLYGGKPITT 210 Query: 203 TVDIWSVGCIMAELL 217 DIW++GC++ +L Sbjct: 211 KADIWALGCLLYKLC 225 >1LUF-A nrPDB Length = 343 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 58/233 (24%), Positives = 90/233 (38%), Gaps = 39/233 (16%) Query: 30 VGSGAYGSVCAAFDTKTGL-------RVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 +G GA+G V A GL VAVK L + + A RE L+ + N Sbjct: 55 IGEGAFGRVFQA--RAPGLLPYEPFTMVAVKMLKEEASADMQADFQ-REAALMAEFDNPN 111 Query: 83 VIGLLDVFTPARS------------LEEF---NDVYLVTHLMGADLNNIVKCQK-----L 122 ++ LL V + L EF + V L +DL+ + L Sbjct: 112 IVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPL 171 Query: 123 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR------HTD 176 + + Q+ G+ Y+ +HRDL N V E+ +KI DFGL+R + Sbjct: 172 SCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYK 231 Query: 177 DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDH 228 + + RW I N Y D+W+ G ++ E+ + G + G H Sbjct: 232 ADGNDAIPIRWMPPESIFYN--RYTTESDVWAYGVVLWEIFSYGLQPYYGMAH 282 >4RT7-A nrPDB Length = 415 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 11/112 (9%) Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG 181 LT + + YQ+ +G++++ +HRDL N+ V +KI DFGLAR + + Sbjct: 240 LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD-SN 298 Query: 182 YVA-------TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPG 225 YV +W APE + + Y D+WS G ++ E+ + G +PG Sbjct: 299 YVVRGNARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFSLGVNPYPG 348 >5E8V-A nrPDB Length = 316 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 45/166 (27%), Positives = 80/166 (48%), Gaps = 28/166 (16%) Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVT--HLMGADLNNIVKCQKLTDDHVQFLIYQI 134 ++KHEN++ L R E +L+T H G +L + ++ + ++ L + Sbjct: 65 NLKHENILQFLTA--EERKTELGKQYWLITAFHAKG-NLQEYLTRHVISWEDLRKLGSSL 121 Query: 135 LRGLKYIHS---------ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM------ 179 RG+ ++HS I+HRDLK SN+ V D + DFGL+ D + Sbjct: 122 ARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLA 181 Query: 180 -TGYVATRWYRAPEIMLNWMH------YNQTVDIWSVGCIMAELLT 218 +G V T Y APE++ + M+ + QT D++S+ ++ E+ + Sbjct: 182 NSGQVGTARYMAPEVLASAMNLENVESFKQT-DVYSMALVLWEMTS 226 >4Y12-A nrPDB Length = 375 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 36/115 (31%), Positives = 58/115 (50%), Gaps = 6/115 (5%) Query: 103 YLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC 162 Y+V +G K QKL + +IL L Y+HS +++ DLKP N+ + E+ Sbjct: 199 YIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE- 257 Query: 163 ELKILDFGLARHTDDEMTGYV-ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAEL 216 +LK++D G + GY+ T ++APEI+ DI++VG +A L Sbjct: 258 QLKLIDLGAVSRINS--FGYLYGTPGFQAPEIVRTGP--TVATDIYTVGRTLAAL 308 >2WTK-B nrPDB Length = 373 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 73/322 (22%), Positives = 125/322 (38%), Gaps = 44/322 (13%) Query: 24 YQNLSPVGSGAYG--SVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 Y+ L+ +G G +V A TG V V++++ S EL + K H Sbjct: 11 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 70 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDD----HVQFLIYQILRG 137 N++ F N++++VT M + C D + +++ +L+ Sbjct: 71 NIVPYRATFIAD------NELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKA 124 Query: 138 LKYIHSADIIHRDLKPSNLAVNED---------CELKILDFGLARHTDDEMTGY-VATRW 187 L YIH +HR +K S++ ++ D L ++ G + + Y V Sbjct: 125 LDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLP 184 Query: 188 YRAPEIM-LNWMHYNQTVDIWSVGCIMAELLTGRTLF---PGTDHI-----DQLKLILRL 238 + +PE++ N Y+ DI+SVG EL G F P T + + +L Sbjct: 185 WLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDT 244 Query: 239 VGTPGAELLKKISSESARNYIQ-SLTQ---------MPKMNFANVFIGANPLAVDLLEKM 288 P EL S A + + SLT P + F +P +E+ Sbjct: 245 STIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTF---SPHFHHFVEQC 301 Query: 289 LVLDSDKRITAAQALAHAYFAQ 310 L + D R +A+ L H++F Q Sbjct: 302 LQRNPDARPSASTLLNHSFFKQ 323 >2PZI-A nrPDB Length = 681 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 36/115 (31%), Positives = 58/115 (50%), Gaps = 6/115 (5%) Query: 103 YLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC 162 Y+V +G K QKL + +IL L Y+HS +++ DLKP N+ + E+ Sbjct: 160 YIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE- 218 Query: 163 ELKILDFGLARHTDDEMTGYV-ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAEL 216 +LK++D G + GY+ T ++APEI+ DI++VG +A L Sbjct: 219 QLKLIDLGAVSRINS--FGYLYGTPGFQAPEIVRTGP--TVATDIYTVGRTLAAL 269 >4HZS-A nrPDB Length = 341 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 69/251 (27%), Positives = 103/251 (41%), Gaps = 51/251 (20%) Query: 27 LSPVGSGAYGSVC-AAFDTKTG--LRVAVKKLSRPFQSIIHAKRTY-RELRLLKHMKHEN 82 L +G G++G V +D +G + VAVK L S A + RE+ + + H N Sbjct: 17 LEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRN 76 Query: 83 VIGLLDV-FTPARSLEEFNDVYLVTHL--MGADLNNIVKCQKLTDDHVQFLI-------Y 132 +I L V TP + +VT L +G+ L+ + K Q FL+ Sbjct: 77 LIRLYGVVLTPP--------MKMVTELAPLGSLLDRLRKHQG------HFLLGTLSRYAV 122 Query: 133 QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYR--- 189 Q+ G+ Y+ S IHRDL NL + +KI DFGL R YV + Sbjct: 123 QVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPF 182 Query: 190 ---APEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAE 245 APE L ++ D W G + E+ T G+ + +G G++ Sbjct: 183 AWCAPE-SLKTRTFSHASDTWMFGVTLWEMFTYGQEPW---------------IGLNGSQ 226 Query: 246 LLKKISSESAR 256 +L KI E R Sbjct: 227 ILHKIDKEGER 237 >1U54-B nrPDB Length = 291 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 68/246 (27%), Positives = 104/246 (42%), Gaps = 41/246 (16%) Query: 27 LSPVGSGAYGSVC-AAFDTKTG--LRVAVKKLSRPFQSIIHAKRTY-RELRLLKHMKHEN 82 L +G G++G V +D +G + VAVK L S A + RE+ + + H N Sbjct: 23 LEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRN 82 Query: 83 VIGLLDV-FTPARSLEEFNDVYLVTHL--MGADLNNIVKCQK--LTDDHVQFLIYQILRG 137 +I L V TP + +VT L +G+ L+ + K Q L ++ + Q+ G Sbjct: 83 LIRLYGVVLTPP--------MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAV-QVAEG 133 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYR------AP 191 + Y+ S IHRDL NL + +KI DFGL R YV + AP Sbjct: 134 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 193 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250 E L ++ D W G + E+ T G+ + +G G+++L KI Sbjct: 194 E-SLKTRTFSHASDTWMFGVTLWEMFTYGQEPW---------------IGLNGSQILHKI 237 Query: 251 SSESAR 256 E R Sbjct: 238 DKEGER 243 >4H1J-A nrPDB Length = 293 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 44/200 (22%), Positives = 94/200 (47%), Gaps = 21/200 (10%) Query: 30 VGSGAYGSVCAAFDTK---TGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGL 86 +G G +G V T + VAVK + ++ + ++ E ++K++ H +++ L Sbjct: 32 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDC-TLDNKEKFMSEAVIMKNLDHPHIVKL 90 Query: 87 LDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQKLTDDHVQFLIY--QILRGLKYIHS 143 + + E +++ L +L + ++ K + + ++Y QI + + Y+ S Sbjct: 91 IGII-------EEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLES 143 Query: 144 ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-----MTGYVATRWYRAPEIMLNWM 198 + +HRD+ N+ V +K+ DFGL+R+ +DE + +W +PE +N+ Sbjct: 144 INCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKW-MSPE-SINFR 201 Query: 199 HYNQTVDIWSVGCIMAELLT 218 + D+W M E+L+ Sbjct: 202 RFTTASDVWMFAVCMWEILS 221 >5TE0-A nrPDB Length = 347 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 48/196 (24%), Positives = 93/196 (47%), Gaps = 28/196 (14%) Query: 44 TKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-HENVIGLLDV-FTPARSLEEFND 101 T G++ A+K++ + + + RE+++++ + H+N++G +D S + + Sbjct: 40 TSNGMKCALKRMFVNNEHDLQVCK--REIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEV 97 Query: 102 VYLVTHLMGADLNNIVKCQKL----TDDHVQFLIYQILRGLKYIHSAD--IIHRDLKPSN 155 + L+ G + N++ Q+L T++ V + + +H IIHRDLK N Sbjct: 98 LILMDFCRGGQVVNLMN-QRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVEN 156 Query: 156 LAVNEDCELKILDFGLARH------------TDDEMTGYVATRWYRAPEIMLNWMH---Y 200 + +++ + DFG A + +DE+ Y T YRAPE M+N Sbjct: 157 ILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKY-TTLSYRAPE-MVNLYSGKII 214 Query: 201 NQTVDIWSVGCIMAEL 216 DIW++GC++ +L Sbjct: 215 TTKADIWALGCLLYKL 230 >3I81-A nrPDB Length = 315 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 57/226 (25%), Positives = 94/226 (41%), Gaps = 35/226 (15%) Query: 18 WEVPERYQNLS-PVGSGAYGSVC-----AAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRE 71 WEV +S +G G++G V + RVA+K ++ S+ E Sbjct: 13 WEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEA-ASMRERIEFLNE 71 Query: 72 LRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADL------------NNIVK 118 ++K +V+ LL V + + ++ LM DL NN V Sbjct: 72 ASVMKEFNCHHVVRLLGVVSQGQP------TLVIMELMTRGDLKSYLRSLRPEMENNPVL 125 Query: 119 CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---HT 175 +Q + +I G+ Y+++ +HRDL N V ED +KI DFG+ R T Sbjct: 126 APPSLSKMIQ-MAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYET 184 Query: 176 D---DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 D G + RW +PE + + + + D+WS G ++ E+ T Sbjct: 185 DYYRKGGKGLLPVRWM-SPESLKDGV-FTTYSDVWSFGVVLWEIAT 228 >3SV0-A nrPDB Length = 483 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 41/160 (25%), Positives = 75/160 (46%), Gaps = 22/160 (13%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVK----KLSRPFQSIIHAKRTYRELRLLKHMKHENVIG 85 +GSG++G + + +T VA+K K P +++ + YR L+ + + G Sbjct: 15 IGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHP--QLLYESKIYRILQGGTGIPNVRWFG 72 Query: 86 LLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIYQILRGLKYIHS 143 + E + LV L+G L ++ +KL+ V L Q++ ++++HS Sbjct: 73 V-----------EGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFVHS 121 Query: 144 ADIIHRDLKPSNLAVN---EDCELKILDFGLARHTDDEMT 180 +HRD+KP N + ++ I+DFGLA+ D T Sbjct: 122 KSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTST 161 >3ZZW-A nrPDB Length = 289 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 52/185 (28%), Positives = 89/185 (48%), Gaps = 23/185 (12%) Query: 71 ELRLLKHMKHENVIGLLDVFTPARSLE------EFNDV--YLV-----THLMGADLNNIV 117 E L ++H NV+ LL V T + L D+ +LV + + D + V Sbjct: 62 EAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTV 121 Query: 118 KCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HT 175 K D V L+ QI G++Y+ S ++H+DL N+ V + +KI D GL R + Sbjct: 122 KSALEPPDFVH-LVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYA 180 Query: 176 DD--EMTG--YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHID 230 D ++ G + RW APE ++ + ++ DIWS G ++ E+ + G + G + D Sbjct: 181 ADYYKLLGNSLLPIRWM-APEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQD 238 Query: 231 QLKLI 235 +++I Sbjct: 239 VVEMI 243 >3MY0-A nrPDB Length = 305 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 88/218 (40%), Gaps = 31/218 (14%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLS-RPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 VG G YG V G VAVK S R QS Y + L +H+N++G + Sbjct: 16 VGKGRYGEVWRGL--WHGESVAVKIFSSRDEQSWFRETEIYNTVLL----RHDNILGFIA 69 Query: 89 VFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIH----- 142 +R+ ++L+TH L + ++ Q L L GL ++H Sbjct: 70 SDMTSRN--SSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFG 127 Query: 143 ---SADIIHRDLKPSNLAVNEDCELKILDFGLA-------RHTDDEMTGYVATRWYRAPE 192 I HRD K N+ V + + I D GLA + D V T+ Y APE Sbjct: 128 TQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPE 187 Query: 193 IM-----LNWMHYNQTVDIWSVGCIMAELLTGRTLFPG 225 ++ + + DIW+ G ++ E + RT+ G Sbjct: 188 VLDEQIRTDCFESYKWTDIWAFGLVLWE-IARRTIVNG 224 >2CMW-A nrPDB Length = 310 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 71/283 (25%), Positives = 120/283 (42%), Gaps = 40/283 (14%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G +G + + T VA+K P +S A + + E R K + GL V Sbjct: 8 IGCGNFGELRLGKNLYTNEYVAIK--LEPIKS--RAPQLHLEYRFYKQLGSAGE-GLPQV 62 Query: 90 --FTPARSLEEFNDVYLVTHLMGADLNNIVK-CQK-LTDDHVQFLIYQILRGLKYIHSAD 145 F P ++N +V L+G L ++ C + T V + Q+L ++Y+HS + Sbjct: 63 YYFGPC---GKYNA--MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKN 117 Query: 146 IIHRDLKPSNLAVNEDCELK-----ILDFGLAR-HTDDEMTGYVATRWYRAPEIMLNWMH 199 +I+RD+KP N + K I+DFGLA+ + D E ++ R +++ +M Sbjct: 118 LIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMS 177 Query: 200 YNQTV--------DIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG-----TPGAEL 246 N + D+ ++G + L G + G D LK + +G TP L Sbjct: 178 INTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDTKRNTPIEAL 236 Query: 247 LKKISSESAR--NYIQSLTQMPKMNFANVFIGANPLAVDLLEK 287 + E A Y++ L K ++ + L DL EK Sbjct: 237 CENFPEEMATYLRYVRRLDFFEKPDYEYL----RTLFTDLFEK 275 >3G2F-A nrPDB Length = 336 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 63/237 (26%), Positives = 98/237 (41%), Gaps = 54/237 (22%) Query: 27 LSPVGSGAYGSVC-AAFDTKTGLRVAVKKLS-RPFQSIIHAKRTYRELRLLKHMKHENV- 83 L +G G YG+V + D + VAVK S Q+ I+ K YR + M+H+N+ Sbjct: 18 LELIGRGRYGAVYKGSLDERP---VAVKVFSFANRQNFINEKNIYR----VPLMEHDNIA 70 Query: 84 ---IGLLDVFTPARS-----LEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQIL 135 +G V R +E + + L +L + + C+ L + + Sbjct: 71 RFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCR---------LAHSVT 121 Query: 136 RGLKYIHSA---------DIIHRDLKPSNLAVNEDCELKILDFGLARH-----------T 175 RGL Y+H+ I HRDL N+ V D I DFGL+ Sbjct: 122 RGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEE 181 Query: 176 DDEMTGYVATRWYRAPEIMLNWMHYN------QTVDIWSVGCIMAELLTGRT-LFPG 225 D+ V T Y APE++ ++ + VD++++G I E+ T LFPG Sbjct: 182 DNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPG 238 >2C47-A nrPDB Length = 313 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 43/180 (23%), Positives = 79/180 (43%), Gaps = 17/180 (9%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G +G + + T VA+K P +S A + + E R K + + + Sbjct: 12 IGCGNFGELRLGKNLYTNEYVAIK--LEPIKS--RAPQLHLEYRFYKQLSATEGVPQVYY 67 Query: 90 FTPARSLEEFNDVYLVTHLMGADLNNIVK-CQK-LTDDHVQFLIYQILRGLKYIHSADII 147 F P +V L+G L ++ C + T V + Q++ ++Y+H+ +I Sbjct: 68 FGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLI 122 Query: 148 HRDLKPSNLAVNEDC-----ELKILDFGLAR-HTDDEMTGYVATRWYRAPEIMLNWMHYN 201 +RD+KP N V + I+DFGLA+ + D E ++ R +++ +M N Sbjct: 123 YRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSIN 182 >5X1R-A nrPDB Length = 302 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 43/168 (25%), Positives = 70/168 (41%), Gaps = 32/168 (19%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVK---------------------KLSRPFQSIIHAKRT 68 +G G +G V A+D + +A+K + + FQ+ +++ Sbjct: 29 IGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQAGLNS--F 86 Query: 69 YRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ--KLTDD 125 +E RLL H GLL V R EE Y+ T G L N+ Q K+ + Sbjct: 87 IQEARLLARFSHP---GLLHVL---RFWEENGTAYMGTQFYSGTTLKNLQAQQPEKIDEA 140 Query: 126 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR 173 ++ L+ + + IH +HRD+ N+ + E +LDFG AR Sbjct: 141 WIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSAR 188 >5CLR-A nrPDB Length = 451 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 30/121 (24%), Positives = 57/121 (47%), Gaps = 7/121 (5%) Query: 104 LVTHLMGADLNNIVKCQKLTDDHVQF-----LIYQILRGLKYIHSADIIHRDLKPSNLAV 158 L T + G DL+ L + F ++ + +K H +IHRDLKP N+ + Sbjct: 150 LTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNIML 209 Query: 159 NEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAEL 216 + D + ++DFG + + T Y APE+ +++ ++Q D++++ + EL Sbjct: 210 DADMQCHLVDFGSSSSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAYSLDEL 269 Query: 217 L 217 Sbjct: 270 F 270 >4M69-B nrPDB Length = 283 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 37/145 (25%), Positives = 69/145 (47%), Gaps = 13/145 (8%) Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG 181 LT L+ + RGL +H ++ +HR++ S+ V ++K+ F L++ + Sbjct: 109 LTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRT 168 Query: 182 YVATRW-------YRAPEIMLN-WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLK 233 +T+ Y +PE + N + Y+ +I+S G ++ E+ TG+ F G D + Sbjct: 169 AKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRE 228 Query: 234 LIL-----RLVGTPGAELLKKISSE 253 L+ VG ELL++I +E Sbjct: 229 LVAEDKKQEPVGQDCPELLREIINE 253 >2Y4I-B nrPDB Length = 319 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 50/219 (22%), Positives = 101/219 (46%), Gaps = 30/219 (13%) Query: 18 WEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 W++P E+ + +G G +G V + + VA++ + + K RE+ + Sbjct: 28 WDIPFEQLEIGELIGKGRFGQV---YHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYR 84 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDD--HVQFLIYQ 133 +HENV+ + L ++T L G L ++V+ K+ D + + + Sbjct: 85 QTRHENVVLFMGACMSPPHLA------IITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQE 138 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGL--------ARHTDDEMTGYVAT 185 I++G+ Y+H+ I+H+DLK N+ ++ ++ I DFGL A +D++ Sbjct: 139 IVKGMGYLHAKGILHKDLKSKNV-FYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGW 197 Query: 186 RWYRAPEIMLNW--------MHYNQTVDIWSVGCIMAEL 216 + APEI+ + +++ D++++G I EL Sbjct: 198 LCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYEL 236 >5CEK-A nrPDB Length = 263 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 48/190 (25%), Positives = 85/190 (44%), Gaps = 18/190 (9%) Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGL 138 H N+ G+++V L E Y+ D+++ V+ +K L ++ L QI+ + Sbjct: 60 HSNITGIVEVI-----LGE-TKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAV 113 Query: 139 KYIHSADIIHRDLKPSNL--AVNEDCELKIL---DFGLARHTDDEMTGYVATRWYRAPEI 193 + H + I+ DLK + E +L++ D + + DD ++ Y +PEI Sbjct: 114 AHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEI 173 Query: 194 MLNWMHYN-QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 + Y+ + D+WS+G ++ LL GR F +D I R G + + S Sbjct: 174 LNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRR-----GQFCIPEHIS 228 Query: 253 ESARNYIQSL 262 AR I+SL Sbjct: 229 PKARCLIRSL 238 >6DC0-A nrPDB Length = 292 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 48/190 (25%), Positives = 85/190 (44%), Gaps = 18/190 (9%) Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGL 138 H N+ G+++V L E Y+ D+++ V+ +K L ++ L QI+ + Sbjct: 57 HSNITGIVEVI-----LGE-TKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAV 110 Query: 139 KYIHSADIIHRDLKPSNL--AVNEDCELKIL---DFGLARHTDDEMTGYVATRWYRAPEI 193 + H + I+ DLK + E +L++ D + + DD ++ Y +PEI Sbjct: 111 AHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEI 170 Query: 194 MLNWMHYN-QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 + Y+ + D+WS+G ++ LL GR F +D I R G + + S Sbjct: 171 LNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRR-----GQFCIPEHIS 225 Query: 253 ESARNYIQSL 262 AR I+SL Sbjct: 226 PKARCLIRSL 235 >2CHL-A nrPDB Length = 351 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 42/180 (23%), Positives = 80/180 (44%), Gaps = 17/180 (9%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G +G + + T VA+K P +S A + + E R K + + I + Sbjct: 38 IGCGNFGELRLGKNLYTNEYVAIK--LEPMKS--RAPQLHLEYRFYKQLGSGDGIPQVYY 93 Query: 90 FTPARSLEEFNDVYLVTHLMGADLNNIVK-CQK-LTDDHVQFLIYQILRGLKYIHSADII 147 F P +V L+G L ++ C + + V + Q++ ++Y+HS ++I Sbjct: 94 FGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLI 148 Query: 148 HRDLKPSNLAVNEDCE-----LKILDFGLAR-HTDDEMTGYVATRWYRAPEIMLNWMHYN 201 +RD+KP N + + I+DF LA+ + D E ++ R +++ +M N Sbjct: 149 YRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSIN 208 >4BTF-A nrPDB Length = 469 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 35/138 (25%), Positives = 67/138 (48%), Gaps = 13/138 (9%) Query: 129 FLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW- 187 L+ + RGL +H ++ +HR++ S+ V ++K+ F L++ + +T+ Sbjct: 302 LLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAE 361 Query: 188 ------YRAPEIMLN-WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL---- 236 Y +PE + N + Y+ +I+S G ++ E+ TG+ F G D +L+ Sbjct: 362 RSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKK 421 Query: 237 -RLVGTPGAELLKKISSE 253 VG ELL++I +E Sbjct: 422 QEPVGQDCPELLREIINE 439 >1PY5-A nrPDB Length = 326 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 66/248 (26%), Positives = 106/248 (42%), Gaps = 35/248 (14%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLS-RPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 +G G +G V G VAVK S R +S Y+ + L +HEN++G Sbjct: 37 IGKGRFGEVWRG--KWRGEEVAVKIFSSREERSWFREAEIYQTVML----RHENILGF-- 88 Query: 89 VFTPARSLEEFNDVYLVT--HLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIH---- 142 + + + ++LV+ H G+ L + + +T + + L GL ++H Sbjct: 89 IAADNKDNGTWTQLWLVSDYHEHGS-LFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIV 147 Query: 143 ----SADIIHRDLKPSNLAVNEDCELKILDFGLA-RH------TDDEMTGYVATRWYRAP 191 I HRDLK N+ V ++ I D GLA RH D V T+ Y AP Sbjct: 148 GTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAP 207 Query: 192 EIM---LNWMHYN--QTVDIWSVGCIMAELLTGRTLFPGTDHID-QLKLILRLVGTPGAE 245 E++ +N H+ + DI+++G + E+ R G H D QL + P E Sbjct: 208 EVLDDSINMKHFESFKRADIYAMGLVFWEI--ARRCSIGGIHEDYQLPYYDLVPSDPSVE 265 Query: 246 LLKKISSE 253 ++K+ E Sbjct: 266 EMRKVVCE 273 >4XHH-A nrPDB Length = 403 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 43/165 (26%), Positives = 78/165 (47%), Gaps = 18/165 (10%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII--HAKRTYRELRLLKH 77 V +++ +GSG++G + + +G VA++ +SI H + Y E R+ K+ Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIR-----LESIRSRHPQLDY-ESRVYKY 58 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK-C-QKLTDDHVQFLIYQIL 135 + I + F E+N +V L+G L ++ C +K + V L Q++ Sbjct: 59 LSGGVGIPFIRWFGRE---GEYNA--MVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMI 113 Query: 136 RGLKYIHSADIIHRDLKPSNLAVN---EDCELKILDFGLARHTDD 177 ++YIH IHRD+KP N + + ++DFGL++ D Sbjct: 114 CRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRD 158 >4XHL-A nrPDB Length = 394 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 39/165 (23%), Positives = 74/165 (44%), Gaps = 18/165 (10%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVK--KLSRPFQSIIHAKRTYRELRLLKH 77 V +++ +GSG++G + + +G VA++ + + + R YR L Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRYL----- 59 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK-C-QKLTDDHVQFLIYQIL 135 +G+ + R E+N +V L+G L ++ C ++ + V L Q+ Sbjct: 60 ---SGGVGIPFIRWFGRE-GEYNA--MVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMF 113 Query: 136 RGLKYIHSADIIHRDLKPSNLAVN---EDCELKILDFGLARHTDD 177 ++YIH IHRD+KP N + + ++DFGL++ D Sbjct: 114 CRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRD 158 >4JRN-A nrPDB Length = 372 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 54/248 (21%), Positives = 97/248 (39%), Gaps = 63/248 (25%) Query: 19 EVPERYQNLS-----------PVGSGAYGSVCAAFDTKTGLRVAVKKL---SRPF-QSII 63 +VP+R+ +++ P+GSG + +V A D +T +AVK P ++++ Sbjct: 54 DVPKRFVSVTTGETRTLVRGAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETML 113 Query: 64 HAKR---TYRELRLLKHMKH-----------------------ENVIGLLDVFTPARSLE 97 +R YR L K K E VIGL + P Sbjct: 114 DLQRESSCYRNFSLAKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVP----- 168 Query: 98 EFNDVYLVTHLMGADLNNIVKCQKLTDDHVQ----------FLIYQILRGLKYIHSADII 147 + +L+ AD++ ++ D V +L Q ++ + + + I+ Sbjct: 169 ---NYFLLMMRAEADMSKVISW-VFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIV 224 Query: 148 HRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPE--IMLNWMHYNQTVD 205 H D+KP+N + +D L + DFG R ++ + + T Y PE + Y D Sbjct: 225 HTDIKPANFLLLKDGRLFLGDFGTYR-INNSVGRAIGTPGYEPPERPFQATGITYTFPTD 283 Query: 206 IWSVGCIM 213 W +G + Sbjct: 284 AWQLGITL 291 >3LMG-A nrPDB Length = 344 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 48/214 (22%), Positives = 92/214 (42%), Gaps = 37/214 (17%) Query: 25 QNLSPVGSGAYGSVCAAFDTKTGLRVAV---------KKLSRPFQSIIHAKRTYRELRLL 75 + L +GSG +G+V G + + K + FQ++ + + Sbjct: 34 RKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTD------HMLAI 87 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLI-- 131 + H +++ LL P SL+ LVT + G+ L+++ + + Q L+ Sbjct: 88 GSLDHAHIVRLLG-LCPGSSLQ------LVTQYLPLGSLLDHVRQHRGALGP--QLLLNW 138 Query: 132 -YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGY----VA 184 QI +G+ Y+ ++HR+L N+ + ++++ DFG+A DD+ Y Sbjct: 139 GVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTP 198 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 +W I ++ Y D+WS G + EL+T Sbjct: 199 IKWMALESI--HFGKYTHQSDVWSYGVTVWELMT 230 >4L68-A nrPDB Length = 340 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 60/235 (25%), Positives = 104/235 (44%), Gaps = 32/235 (13%) Query: 47 GLRVAVKKLSRPFQSIIHAKRTYR-ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLV 105 G +AVK LS + +R +R E+ L ++H N+ LL +EE + +LV Sbjct: 64 GSALAVKHLS----TCKLGEREFRYEMNQLWELRHSNLAPLLGFCV----VEE--EKFLV 113 Query: 106 THLMG-ADLNNIVKCQKLTDD-HVQFLI-YQILRGLKYIHSA---DIIHRDLKPSNLAVN 159 M L++++ + D +F I RGL ++H I+H+++ S + ++ Sbjct: 114 YKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSVILID 173 Query: 160 EDCELKILDFGLAR-------HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCI 212 ED + +I+D GLAR + MTG + Y APE M + D++ +G + Sbjct: 174 EDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTT-MLASLKGDVYGLGVV 232 Query: 213 MAELLTGRTLFPG-------TDHIDQLKLILRLVGTPGAELLKKISSESARNYIQ 260 + EL TG G D + QL+ R+ T + K E +++ Sbjct: 233 LLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDEEISKFVE 287 >5WNL-A nrPDB Length = 342 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 11/152 (7%) Query: 104 LVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIH--SADIIHRDLKPSNLAVNED 161 ++ ++ L ++ + L D ++++ G+ ++H S ++H +LKP+N+ ++ Sbjct: 95 VMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLLHLNLKPANILLDAH 154 Query: 162 CELKILDFGLAR-----HTDD-EMTGYVATRWYRAPE-IMLNWMHYNQTVDIWSVGCIMA 214 +KI DFGLA+ H+ D M G T Y PE I ++ D++S ++ Sbjct: 155 YHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIW 214 Query: 215 ELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 +LT + F D + L +++++V EL Sbjct: 215 GVLTQKKPF--ADEKNILHIMMKVVKGHRPEL 244 >4IX6-A nrPDB Length = 350 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 60/244 (24%), Positives = 98/244 (40%), Gaps = 51/244 (20%) Query: 97 EEFNDVYLVTHLMGADLNNIVKCQKLTDDHV-QFLIYQILRGLKYIHSADIIHRDLKPSN 155 E N V + A L + C T+ V + + ++L L +H ++HRD+KP+N Sbjct: 114 EGENTVEALMRRGTAPLATAMACADATELGVTKKAMRELLGSLARLHECGVVHRDVKPAN 173 Query: 156 L--AVNEDCELKILDFGLAR-----------HTDDEMTGYVATRWYRAPEIML------- 195 L A + LK++D G A + D G R+ +A E+ L Sbjct: 174 LIAAEKDGGVLKLIDLGAAALCLPLPETLNYYPGD---GPADPRYAKADELYLLPPGSPR 230 Query: 196 --------NW-MHYNQTVDIWSVGCIMAEL-LTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 W H D WS GC+M +L + G G +++ + VG Sbjct: 231 PTKDNAAKLWEAHKPDRFDSWSAGCVMLQLAVVGLRTDAG---LERFLADYKAVGYD--- 284 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAV-DLLEKMLVLDSDKRITAAQALA 304 + E + Y M+FA + AN A DL ++++ + D R + AL+ Sbjct: 285 -VNAFRGEKSGEY-------GTMDFAA--LDANGGAGWDLCQRLMEAERDARASCEAALS 334 Query: 305 HAYF 308 HA+F Sbjct: 335 HAFF 338 >4CI6-B nrPDB Length = 643 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 22/94 (23%), Positives = 52/94 (55%), Gaps = 6/94 (6%) Query: 127 VQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE-DCELKILDFGLARHTDDEMTGYVAT 185 ++F+ +++L ++ A I+H D+KP N+ + E ++D GL + ++ G+ T Sbjct: 158 IKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGF--T 215 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTG 219 ++APE+ + + ++ D++ +++ LL G Sbjct: 216 ESFKAPELGVGNLGASEKSDVF---LVVSTLLHG 246 >4NT4-A nrPDB Length = 312 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 38/154 (24%), Positives = 70/154 (45%), Gaps = 16/154 (10%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSI---IHAKRTYRELRLLKHMKHENVIGL 86 +G G +G + + VA+K P +S +H + YR +LL G+ Sbjct: 20 IGCGNFGELRLGKNLYNNEHVAIK--MEPMKSKAPQLHLE--YRFYKLLGSHADNAPDGI 75 Query: 87 LDVFTPARSLEEFNDVYLVTHLMGADLNNI--VKCQKLTDDHVQFLIYQILRGLKYIHSA 144 ++ +N +V L+G L ++ + +K + V + Q+L ++Y+HS Sbjct: 76 PRIYHLGTCGGRYNA--MVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVHSR 133 Query: 145 DIIHRDLKPSNLAVNEDCE-----LKILDFGLAR 173 +I+RD+KP N + + I+DFGLA+ Sbjct: 134 HLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAK 167 >5AR8-A nrPDB Length = 326 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 42/162 (25%), Positives = 72/162 (44%), Gaps = 26/162 (16%) Query: 26 NLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHA-------KRTYRELRLLKHM 78 +L + GA G+V +A ++VAVK L IH K RE +L Sbjct: 36 DLRYLSRGASGTVSSARHADWRVQVAVKHLH------IHTPLLDSERKDVLREAEILHKA 89 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQILR- 136 + ++ +L + L +VT M LN ++ + D L ++IL Sbjct: 90 RFSYILPILGICNEPEFLG------IVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHE 143 Query: 137 ---GLKYIH--SADIIHRDLKPSNLAVNEDCELKILDFGLAR 173 G+ Y+H + ++H DLK N+ ++ + +KI DFGL++ Sbjct: 144 IALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSK 185 >5VDK-A nrPDB Length = 297 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 62/284 (21%), Positives = 121/284 (42%), Gaps = 29/284 (10%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYREL---RLLKHMKHENVIGL 86 +G G +G+V G A+K+ + F + + E+ +L H H +V+ Sbjct: 23 IGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGH--HPHVVRY 80 Query: 87 LDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADI 146 + + N+ L A N + ++ ++ QI GL YIH++ + Sbjct: 81 YSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSM 140 Query: 147 IHRDLKPSNLAVNEDC-ELKILDFGLARHTDDEMTGYVATRWYRAPEIM--LNWMHYNQT 203 +H D+KPSN+ + C +++ G+ ++E W+ + +M + + + + Sbjct: 141 VHLDIKPSNIFI---CHKMQSESSGVIEEVENE------ADWFLSANVMYKIGDLGHATS 191 Query: 204 VDIWSVGCIMAELLTGRTLFPGTDHI---DQLKLILRLVGTPGAELLKKISSESARNYIQ 260 ++ V + L L H+ D L L + GAE L ++ +A ++I+ Sbjct: 192 INKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLP--TNGAAWHHIR 249 Query: 261 SLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304 K NF +V + LL+ M+ D+++R +AA ALA Sbjct: 250 ------KGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAA-ALA 286 >5X18-A nrPDB Length = 295 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 37/166 (22%), Positives = 78/166 (46%), Gaps = 20/166 (12%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS--IIHAKRTYRELRLLKHMKHE 81 Y+ +G G++G + + G+ VA+K R ++ + +TY+ L ++ + Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPNIPYA 68 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK-C-QKLTDDHVQFLIYQILRGLK 139 G E +++ LV L+G L ++ C +K + V + Q++ ++ Sbjct: 69 YYFGQ----------EGLHNI-LVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIE 117 Query: 140 YIHSADIIHRDLKPSNLAVNEDCE-----LKILDFGLARHTDDEMT 180 +H+ D+I+RD+KP N + + + ++DFG+A+ D T Sbjct: 118 DLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKT 163 >4MWI-A nrPDB Length = 294 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/192 (22%), Positives = 87/192 (45%), Gaps = 23/192 (11%) Query: 61 SIIHAKRTY-RELRLLKHMKHENVIGLLDV-----FTPARSLEEFNDVYLVTHLMGADLN 114 SI ++T+ +E++ +K + N++ + + TP +F+ V L L Sbjct: 62 SIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPP----QFSIVMEYCEL--GTLR 115 Query: 115 NIVKCQK-LTDDHVQFLIYQILRGLKYIHSADI--IHRDLKPSNLAVNEDCELKILDFGL 171 ++ +K LT L+ RGL +H ++ +H ++ SN V + ++K+ F L Sbjct: 116 ELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFEL 175 Query: 172 AR-------HTDDEMTGYVATRWYRAPEIMLN-WMHYNQTVDIWSVGCIMAELLTGRTLF 223 + T E T V + Y +P+ + + + Y+ +I+S G ++ E+ TG F Sbjct: 176 RKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPF 235 Query: 224 PGTDHIDQLKLI 235 G + KL+ Sbjct: 236 QGCNSEKIRKLV 247 >1CSN-A nrPDB Length = 298 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 37/158 (23%), Positives = 72/158 (45%), Gaps = 16/158 (10%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G++G + + +VA+K R + YR +LL G+ +V Sbjct: 18 IGEGSFGVIFEGTNLLNNQQVAIKFEPRR-SDAPQLRDEYRTYKLL-----AGCTGIPNV 71 Query: 90 FTPARSLEEFNDVYLVTHLMGADLNNIVK-C-QKLTDDHVQFLIYQILRGLKYIHSADII 147 + + E ++V LV L+G L +++ C +K + V Q+L ++ IH ++ Sbjct: 72 YYFGQ--EGLHNV-LVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSLV 128 Query: 148 HRDLKPSNLAVNEDCE-----LKILDFGLARHTDDEMT 180 +RD+KP N + + ++DFG+ + D +T Sbjct: 129 YRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVT 166 >6BFN-A nrPDB Length = 342 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 47/211 (22%), Positives = 82/211 (38%), Gaps = 27/211 (12%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 89 +G G +G V A T V K + + + E+ L +H N++ Sbjct: 30 IGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGY 89 Query: 90 FTPARSLEEFNDVYLVTH--LMGADLNNIVKCQKLTDDHVQF-----LIYQILRGLKYIH 142 N Y + + L L + + CQ + + ++ R ++++H Sbjct: 90 CAQ-------NGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLH 142 Query: 143 --SADIIHRDLKPSNLAVNEDCELKILDFGLARH-----TDDEMTGYVA-TRWYRA---- 190 S +IH D+K SN+ ++E K+ DFGLAR + + VA T+ R Sbjct: 143 QDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAY 202 Query: 191 -PEIMLNWMHYNQTVDIWSVGCIMAELLTGR 220 PE + D +S G ++ E L G+ Sbjct: 203 LPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >2RSV-A nrPDB Length = 403 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 23/74 (31%), Positives = 41/74 (55%), Gaps = 4/74 (5%) Query: 103 YLVTHLMGADLNNI--VKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE 160 +++ G+DL I ++ + V L +IL L+YIH + +H D+K SNL +N Sbjct: 135 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 194 Query: 161 DC--ELKILDFGLA 172 ++ ++D+GLA Sbjct: 195 KNPDQVYLVDYGLA 208 >2LAV-A nrPDB Length = 361 Score = 37.4 bits (85), Expect = 0.011, Method: Compositional matrix adjust. Identities = 23/74 (31%), Positives = 41/74 (55%), Gaps = 4/74 (5%) Query: 103 YLVTHLMGADLNNI--VKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE 160 +++ G+DL I ++ + V L +IL L+YIH + +H D+K SNL +N Sbjct: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 Query: 161 DC--ELKILDFGLA 172 ++ ++D+GLA Sbjct: 188 KNPDQVYLVDYGLA 201 >3ENH-A nrPDB Length = 540 Score = 33.9 bits (76), Expect = 0.099, Method: Compositional matrix adjust. Identities = 17/44 (38%), Positives = 26/44 (59%), Gaps = 2/44 (4%) Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR 173 + Y+I + +H D+IH DL SN ++D L I+DFGL + Sbjct: 436 IAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGK 477 >5OAT-A nrPDB Length = 411 Score = 33.5 bits (75), Expect = 0.16, Method: Compositional matrix adjust. Identities = 32/115 (27%), Positives = 51/115 (44%), Gaps = 20/115 (17%) Query: 137 GLKYIHSADIIHRDLKPSNLAVN----EDCELKILDFG--LARHTDDEMTGYVATRWYR- 189 G+ ++ + I HRDLK NL ++ E L I DFG LA T+ Y + + Sbjct: 165 GVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKG 224 Query: 190 ------APEIM------LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQL 232 APEI+ + ++Y++ D+W+VG I E+ F G + Sbjct: 225 GNTALMAPEIICQKPGTFSVLNYSK-ADLWAVGAIAYEIFNCHNPFYGPSRLKNF 278 >5UU1-A nrPDB Length = 324 Score = 33.1 bits (74), Expect = 0.20, Method: Compositional matrix adjust. Identities = 37/157 (23%), Positives = 71/157 (45%), Gaps = 15/157 (9%) Query: 30 VGSGAYGSVCAAF-------DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 +GSG +G + AF D + ++V ++ F + +R ++ + K ++ + Sbjct: 24 IGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQ 83 Query: 83 VIGLLDVFTPARSLEEFNDV---YLVTHLMGADLNNIV-KCQKLTDDHVQFLIYQILRGL 138 + L L EF ++V +G DL I + V L ++L L Sbjct: 84 LDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVL 143 Query: 139 KYIHSADIIHRDLKPSNLAV---NEDCELKILDFGLA 172 +YIH + +H D+K +NL + N D ++ + D+GL+ Sbjct: 144 EYIHENEYVHGDIKAANLLLGYKNPD-QVYLADYGLS 179 >5UV4-A nrPDB Length = 311 Score = 32.7 bits (73), Expect = 0.27, Method: Compositional matrix adjust. Identities = 50/205 (24%), Positives = 81/205 (39%), Gaps = 21/205 (10%) Query: 30 VGSGAYG-SVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 +G +G S A D G + VK L F K RE++ L ++H N++ L Sbjct: 33 IGRSCHGTSYKATLDN--GYMLTVKWLKEGFAK--SKKEFSREIKKLGSVRHPNLVPLRG 88 Query: 89 VFTPARSLEEF------NDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIH 142 + + E + L T+L D N+ L+ + I R L Y+H Sbjct: 89 YYWGPKEHERIMISDYADATSLSTYLSEFDERNL---PPLSAGQRLNIAIDIARCLDYLH 145 Query: 143 SADII-HRDLKPSNLAV-NEDCELKILDFGLARHTDD----EMTGYVATRWYRAPEIMLN 196 + +I H ++K SN+ + N + D+ L R E Y PE Sbjct: 146 NERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSST 205 Query: 197 WMHY-NQTVDIWSVGCIMAELLTGR 220 + D+++ G I+ ELLTG+ Sbjct: 206 SKPCPSLKSDVYAFGVILLELLTGK 230 >6EQI-C nrPDB Length = 433 Score = 32.3 bits (72), Expect = 0.29, Method: Compositional matrix adjust. Identities = 28/105 (26%), Positives = 45/105 (42%), Gaps = 27/105 (25%) Query: 137 GLKYIHSADIIHRDLKPSNLAVNED-----CELKILDFGLA------------RHTDDEM 179 + +++ +I HRDLK N+ V+ + I DFG R D + Sbjct: 179 AVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDK 238 Query: 180 TGYVATRWYRAPEI------MLNWMHYNQTVDIWSVGCIMAELLT 218 G R APEI +W++Y ++ D+W+VG I E+ Sbjct: 239 GG---NRALMAPEIANAKPGTFSWLNYKKS-DLWAVGAIAYEIFN 279 >5M07-A nrPDB Length = 276 Score = 32.0 bits (71), Expect = 0.41, Method: Compositional matrix adjust. Identities = 25/106 (23%), Positives = 42/106 (39%), Gaps = 22/106 (20%) Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNE----DCELKILDFGLARHTDDEMTGYVAT 185 ++ + L Y H ++HRD+ P+N+ + D + + DFG+A Sbjct: 137 IVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQPS--------- 187 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQ 231 Y APE+ + D+ A LT LF G +D+ Sbjct: 188 --YPAPEL-------SAGADVDGRADQYALALTAIHLFAGAPPVDR 224 >5VE6-A nrPDB Length = 492 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 14/33 (42%), Positives = 20/33 (60%) Query: 124 DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNL 156 + V FL+ Q+ GL+++ IIHRDL NL Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENL 239 >6EWX-A nrPDB Length = 484 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 14/33 (42%), Positives = 20/33 (60%) Query: 124 DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNL 156 + V FL+ Q+ GL+++ IIHRDL NL Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENL 241 >6J6I-B nrPDB Length = 351 Score = 28.5 bits (62), Expect = 4.9, Method: Compositional matrix adjust. Identities = 20/96 (20%), Positives = 46/96 (47%), Gaps = 9/96 (9%) Query: 133 QILRGLKYIHSA---DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYR 189 +I + Y+H+A IIHRD+KP ++ ++++ K+ D + E + W Sbjct: 171 EIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISL-PEGKSRIEAEWVL 229 Query: 190 APEIMLNWMHY-----NQTVDIWSVGCIMAELLTGR 220 ++ +++ + D++S G + ++TG+ Sbjct: 230 GTFGYIDPLYHKTCFVTEYTDVYSFGICLLVIITGK 265 >6G4J-A nrPDB Length = 315 Score = 28.1 bits (61), Expect = 6.2, Method: Compositional matrix adjust. Identities = 15/45 (33%), Positives = 22/45 (48%), Gaps = 1/45 (2%) Query: 127 VQFLIYQILRGLKYIHSADIIHRDLKPSNLAV-NEDCELKILDFG 170 + L+ Q+L L +H I DLKP NL V ++ +D G Sbjct: 125 IPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVG 169 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4EWQ-A nrPDB 535 e-152 3OHT-A nrPDB 514 e-146 3GC9-A nrPDB 467 e-132 1CM8-A nrPDB 448 e-126 4MYG-A nrPDB 426 e-120 4QTB-A nrPDB 385 e-107 5AWM-A nrPDB 385 e-107 5NGU-A nrPDB 381 e-106 1JNK-A nrPDB 378 e-105 4IC8-A nrPDB 377 e-105 2XS0-A nrPDB 376 e-104 4ZSG-A nrPDB 374 e-104 3E7O-A nrPDB 373 e-104 6DTL-A nrPDB 373 e-104 2F9G-A nrPDB 370 e-103 5Z33-A nrPDB 365 e-101 3FI2-A nrPDB 359 1e-99 4QNY-A nrPDB 343 7e-95 3OZ6-A nrPDB 334 2e-92 2BPM-A nrPDB 333 5e-92 4O2Z-A nrPDB 330 5e-91 3NIZ-A nrPDB 328 2e-90 6GU6-A nrPDB 314 4e-86 3RP9-A nrPDB 313 9e-86 4AU8-A nrPDB 309 9e-85 4KRC-A nrPDB 309 1e-84 3N9X-A nrPDB 308 3e-84 1V0B-A nrPDB 306 8e-84 3NIE-A nrPDB 304 5e-83 3PG1-A nrPDB 303 6e-83 3NCG-A nrPDB 303 8e-83 3DFA-A nrPDB 301 3e-82 4NST-A nrPDB 299 2e-81 3LIJ-A nrPDB 298 3e-81 3MA6-A nrPDB 297 7e-81 5EFQ-A nrPDB 296 7e-81 3DXN-A nrPDB 296 7e-81 1UA2-A nrPDB 296 9e-81 2I6L-A nrPDB 294 3e-80 5JN2-A nrPDB 293 7e-80 4BBM-A nrPDB 292 1e-79 4AGU-A nrPDB 291 3e-79 3MIA-A nrPDB 289 2e-78 3HZT-A nrPDB 288 3e-78 1G3N-A nrPDB 286 8e-78 4RGJ-A nrPDB 283 8e-77 4MVF-A nrPDB 282 2e-76 2V7O-A nrPDB 281 5e-76 5AIR-A nrPDB 278 2e-75 2VN9-A nrPDB 278 2e-75 5G6V-A nrPDB 277 4e-75 5FG8-A nrPDB 277 4e-75 2VZ6-A nrPDB 275 2e-74 4E7W-A nrPDB 274 4e-74 5U6Y-A nrPDB 274 4e-74 2W96-B nrPDB 274 5e-74 2BDW-A nrPDB 273 6e-74 3Q5I-A nrPDB 273 8e-74 3BHH-A nrPDB 272 2e-73 4BGQ-A nrPDB 271 3e-73 3SOA-A nrPDB 271 4e-73 3GC0-A nrPDB 270 5e-73 3KK8-A nrPDB 270 7e-73 5ES1-A nrPDB 269 9e-73 3ZDU-A nrPDB 269 1e-72 4YZB-A nrPDB 269 1e-72 2QNJ-A nrPDB 268 3e-72 5Y86-A nrPDB 267 4e-72 4NIF-A nrPDB 267 4e-72 3MN3-A nrPDB 267 7e-72 5KZ7-A nrPDB 266 1e-71 4JG6-A nrPDB 265 2e-71 5IG1-A nrPDB 264 5e-71 2JC6-A nrPDB 264 6e-71 4FG9-A nrPDB 262 1e-70 2YCR-A nrPDB 261 2e-70 3H4J-B nrPDB 261 4e-70 5ZTN-A nrPDB 260 6e-70 4REW-A nrPDB 259 1e-69 3IS5-A nrPDB 259 2e-69 3COM-A nrPDB 258 2e-69 5WAX-A nrPDB 258 2e-69 5YKS-A nrPDB 257 4e-69 3E3P-A nrPDB 256 8e-69 4D2V-A nrPDB 255 2e-68 3UTO-A nrPDB 255 3e-68 4CFF-A nrPDB 254 4e-68 2J90-A nrPDB 254 4e-68 4CFH-A nrPDB 254 5e-68 4RED-A nrPDB 254 5e-68 5JZN-A nrPDB 254 7e-68 5EZV-A nrPDB 253 8e-68 3EB0-A nrPDB 253 8e-68 4CQG-A nrPDB 253 1e-67 6FD3-A nrPDB 253 1e-67 3D2K-A nrPDB 252 1e-67 2JAM-A nrPDB 252 1e-67 1KOA-A nrPDB 252 2e-67 3I6U-A nrPDB 252 2e-67 4LG4-A nrPDB 252 2e-67 3ZUT-A nrPDB 252 2e-67 3F3Z-A nrPDB 251 3e-67 6C9D-A nrPDB 251 3e-67 4UZD-A nrPDB 251 4e-67 3UC3-A nrPDB 250 6e-67 2Y7J-A nrPDB 250 7e-67 4CZT-A nrPDB 250 7e-67 2HAK-A nrPDB 250 9e-67 5XZW-A nrPDB 250 9e-67 6AO5-A nrPDB 249 1e-66 3UDB-A nrPDB 249 1e-66 3GUB-A nrPDB 247 4e-66 2YAB-A nrPDB 247 6e-66 5J5T-A nrPDB 247 7e-66 3TAC-A nrPDB 247 8e-66 2F57-A nrPDB 246 1e-65 2YZA-A nrPDB 246 1e-65 2HW6-A nrPDB 246 1e-65 4B6L-A nrPDB 245 1e-65 2W4O-A nrPDB 245 1e-65 3HKO-A nrPDB 245 2e-65 1PHK-A nrPDB 245 2e-65 3DAK-A nrPDB 245 2e-65 1FOT-A nrPDB 244 4e-65 4KS7-A nrPDB 244 5e-65 5D7A-A nrPDB 244 6e-65 4JXF-A nrPDB 244 7e-65 2A27-A nrPDB 243 9e-65 4D28-A nrPDB 243 9e-65 4FIE-A nrPDB 243 1e-64 5D9K-A nrPDB 242 2e-64 3Q53-A nrPDB 242 2e-64 2Q0N-A nrPDB 242 2e-64 4JDH-A nrPDB 242 2e-64 3MV5-A nrPDB 242 2e-64 4XBR-A nrPDB 242 2e-64 1ZWS-A nrPDB 241 3e-64 5KCV-A nrPDB 241 3e-64 4PDS-A nrPDB 241 4e-64 4L42-A nrPDB 241 4e-64 5X8I-B nrPDB 240 5e-64 6FYV-A nrPDB 240 5e-64 3DB8-A nrPDB 240 6e-64 6CKI-A nrPDB 240 7e-64 1KOB-A nrPDB 240 7e-64 2UV2-A nrPDB 240 7e-64 2JDO-A nrPDB 239 1e-63 4QMW-A nrPDB 238 3e-63 4I6B-A nrPDB 238 3e-63 6O6Q-A nrPDB 238 4e-63 2XIK-A nrPDB 237 4e-63 4FZF-B nrPDB 237 6e-63 4RLP-A nrPDB 237 6e-63 2Z7Q-A nrPDB 237 7e-63 2X4F-A nrPDB 237 8e-63 5DBX-A nrPDB 236 1e-62 6FDY-U nrPDB 235 2e-62 3HDN-A nrPDB 235 3e-62 6CMJ-A nrPDB 234 4e-62 4U41-A nrPDB 234 4e-62 2OU7-A nrPDB 234 5e-62 3TXO-A nrPDB 234 6e-62 5F9E-A nrPDB 234 7e-62 4YNZ-A nrPDB 233 1e-61 4J52-A nrPDB 233 1e-61 3LM0-A nrPDB 232 3e-61 2WO6-A nrPDB 231 3e-61 4CSV-A nrPDB 231 3e-61 5X3F-B nrPDB 231 4e-61 5XVU-A nrPDB 229 2e-60 4WB7-A nrPDB 228 3e-60 6HXF-B nrPDB 227 4e-60 3ORZ-A nrPDB 227 7e-60 1U5R-A nrPDB 227 8e-60 3KN6-A nrPDB 227 8e-60 4APC-A nrPDB 226 1e-59 2GCD-A nrPDB 225 2e-59 3ALO-A nrPDB 225 2e-59 5DYK-A nrPDB 225 3e-59 5N23-A nrPDB 225 3e-59 6HMD-A nrPDB 224 4e-59 1VZO-A nrPDB 224 4e-59 3RAW-A nrPDB 224 5e-59 4MD7-E nrPDB 224 5e-59 4B8L-A nrPDB 224 6e-59 5YV8-A nrPDB 224 7e-59 4CRL-A nrPDB 223 9e-59 2WTK-C nrPDB 223 9e-59 5FET-A nrPDB 223 1e-58 4XEY-B nrPDB 222 2e-58 2FO0-A nrPDB 222 2e-58 6ED6-A nrPDB 222 3e-58 6CQF-A nrPDB 222 3e-58 4WNO-A nrPDB 222 3e-58 6E9W-A nrPDB 222 3e-58 2H8H-A nrPDB 221 3e-58 4AF3-A nrPDB 221 3e-58 6F3F-A nrPDB 220 5e-58 6QAU-A nrPDB 220 7e-58 5UNP-A nrPDB 220 7e-58 4C0T-A nrPDB 220 7e-58 5LOH-A nrPDB 220 8e-58 3FXW-A nrPDB 220 8e-58 4RA4-A nrPDB 219 1e-57 6EII-A nrPDB 219 2e-57 2PVN-A nrPDB 218 3e-57 3NYO-A nrPDB 217 7e-57 3PPZ-A nrPDB 216 1e-56 5SYS-A nrPDB 216 1e-56 5KKR-C nrPDB 216 1e-56 3TKU-A nrPDB 216 1e-56 3A8W-A nrPDB 215 2e-56 6E2O-A nrPDB 215 2e-56 6NPU-A nrPDB 215 2e-56 6BDL-A nrPDB 215 3e-56 2XYN-A nrPDB 215 3e-56 3EQC-A nrPDB 214 4e-56 4GS6-A nrPDB 214 5e-56 2BRG-A nrPDB 214 6e-56 4AW2-A nrPDB 213 1e-55 3VN9-A nrPDB 212 2e-55 4IAN-A nrPDB 212 2e-55 3PFQ-A nrPDB 212 2e-55 1NY3-A nrPDB 212 3e-55 4FR4-A nrPDB 212 3e-55 4AN9-A nrPDB 211 4e-55 2OZA-A nrPDB 210 5e-55 3KA0-A nrPDB 210 6e-55 3FME-A nrPDB 209 1e-54 5O2B-A nrPDB 209 1e-54 2DQ7-X nrPDB 209 2e-54 6CCF-A nrPDB 209 2e-54 1S9I-A nrPDB 209 2e-54 2I0E-A nrPDB 208 3e-54 4TNB-A nrPDB 208 3e-54 5O2C-A nrPDB 208 4e-54 5VO2-A nrPDB 207 6e-54 6GQK-A nrPDB 206 1e-53 4E93-A nrPDB 206 2e-53 2WQN-A nrPDB 206 2e-53 2VD5-A nrPDB 205 2e-53 4EBW-A nrPDB 205 2e-53 4CRS-A nrPDB 205 2e-53 4PWN-A nrPDB 205 2e-53 5UUU-A nrPDB 205 3e-53 1ZXE-A nrPDB 205 3e-53 3A4O-X nrPDB 205 3e-53 3PVW-A nrPDB 204 4e-53 3LLT-A nrPDB 204 4e-53 2XNP-A nrPDB 203 6e-53 4KIK-B nrPDB 203 1e-52 5HI2-A nrPDB 203 1e-52 1TKI-A nrPDB 203 1e-52 3C51-A nrPDB 202 2e-52 4OTD-A nrPDB 202 2e-52 5TQX-A nrPDB 202 2e-52 5MJB-A nrPDB 202 2e-52 4XCU-A nrPDB 201 4e-52 3TT0-A nrPDB 201 4e-52 4EQM-A nrPDB 200 7e-52 2Y6O-A nrPDB 200 1e-51 5H2U-A nrPDB 200 1e-51 6E4F-A nrPDB 200 1e-51 5L6P-A nrPDB 199 1e-51 3QA8-A nrPDB 199 2e-51 4WUA-A nrPDB 199 2e-51 2J0K-A nrPDB 199 2e-51 2JD5-A nrPDB 199 2e-51 3CJF-A nrPDB 198 2e-51 4UY9-A nrPDB 198 2e-51 2X7G-A nrPDB 198 3e-51 5HIE-A nrPDB 198 3e-51 4UYA-A nrPDB 198 3e-51 2PL0-A nrPDB 198 4e-51 2HK5-A nrPDB 198 4e-51 1JPA-A nrPDB 198 4e-51 5A46-A nrPDB 198 4e-51 3G0E-A nrPDB 197 6e-51 3GQL-A nrPDB 197 6e-51 3OMV-A nrPDB 197 6e-51 4P5Q-A nrPDB 197 7e-51 5X5O-A nrPDB 197 9e-51 4K33-A nrPDB 197 9e-51 5B2L-A nrPDB 197 1e-50 6BXI-A nrPDB 196 1e-50 3DTC-A nrPDB 196 1e-50 2OGV-A nrPDB 196 1e-50 2VWV-A nrPDB 196 1e-50 4XI2-A nrPDB 196 2e-50 4Y93-A nrPDB 195 2e-50 4AT3-A nrPDB 195 2e-50 2PSQ-A nrPDB 195 2e-50 3BEA-A nrPDB 195 3e-50 2R2P-A nrPDB 195 4e-50 3DLS-A nrPDB 194 4e-50 3KRL-A nrPDB 194 5e-50 1K9A-A nrPDB 194 5e-50 4OLI-A nrPDB 194 6e-50 1AD5-A nrPDB 193 7e-50 3V5Q-A nrPDB 193 7e-50 5AMN-A nrPDB 193 8e-50 5EG3-A nrPDB 193 8e-50 3ORP-A nrPDB 193 1e-49 4XUF-A nrPDB 193 1e-49 3DKO-A nrPDB 193 1e-49 3QGY-A nrPDB 193 1e-49 6DBM-A nrPDB 193 1e-49 5X02-A nrPDB 192 1e-49 6DBN-A nrPDB 192 2e-49 4YHJ-A nrPDB 192 3e-49 1BYG-A nrPDB 192 3e-49 5O0Y-A nrPDB 191 3e-49 4XLV-A nrPDB 191 4e-49 6GVJ-A nrPDB 190 6e-49 5KMM-A nrPDB 190 8e-49 4LFI-A nrPDB 190 1e-48 5U6B-A nrPDB 190 1e-48 3QUP-A nrPDB 189 1e-48 2W1I-A nrPDB 189 1e-48 3KUL-B nrPDB 189 2e-48 4R7H-A nrPDB 188 2e-48 5AP3-A nrPDB 188 3e-48 5FM2-A nrPDB 188 3e-48 2WTK-B nrPDB 188 4e-48 5TUR-A nrPDB 187 6e-48 1FVR-A nrPDB 187 7e-48 3BGP-A nrPDB 187 7e-48 3HMP-A nrPDB 187 9e-48 5VD3-A nrPDB 186 1e-47 4PDO-A nrPDB 186 1e-47 1LUF-A nrPDB 186 1e-47 4E20-A nrPDB 185 2e-47 3SXS-A nrPDB 185 2e-47 4YFF-A nrPDB 185 2e-47 5HLW-A nrPDB 185 2e-47 4RC3-A nrPDB 185 2e-47 4H1J-A nrPDB 185 3e-47 6B2Q-A nrPDB 185 3e-47 4X3F-A nrPDB 185 3e-47 4OW8-A nrPDB 185 3e-47 4X7Q-B nrPDB 185 3e-47 4C59-A nrPDB 185 3e-47 5HVK-A nrPDB 185 3e-47 3C1X-A nrPDB 185 3e-47 3ZBF-A nrPDB 185 4e-47 4Y83-A nrPDB 184 4e-47 3M42-A nrPDB 184 4e-47 5UIU-A nrPDB 184 4e-47 5GRN-A nrPDB 184 5e-47 2ZMD-A nrPDB 184 5e-47 4HVI-A nrPDB 184 5e-47 4M7I-A nrPDB 184 5e-47 3PLS-A nrPDB 183 8e-47 3IO7-A nrPDB 183 8e-47 5U6C-A nrPDB 183 9e-47 4HZS-A nrPDB 182 2e-46 4NEU-A nrPDB 182 2e-46 6FEX-A nrPDB 181 3e-46 3BBT-B nrPDB 181 5e-46 1U54-B nrPDB 180 6e-46 1U59-A nrPDB 180 9e-46 6CTH-A nrPDB 180 9e-46 6BSD-A nrPDB 180 1e-45 2A1A-B nrPDB 179 2e-45 4TPT-A nrPDB 179 2e-45 3PP0-A nrPDB 178 2e-45 3I81-A nrPDB 178 3e-45 2OZO-A nrPDB 178 3e-45 5GNK-A nrPDB 177 8e-45 3LZB-A nrPDB 176 1e-44 3Q4U-A nrPDB 176 1e-44 3UIU-A nrPDB 175 2e-44 2RIO-A nrPDB 175 2e-44 4IDT-A nrPDB 175 3e-44 5TOS-A nrPDB 174 5e-44 2BUJ-A nrPDB 172 2e-43 4PL5-B nrPDB 172 3e-43 4LRM-A nrPDB 171 4e-43 6HV0-A nrPDB 171 5e-43 5LPZ-A nrPDB 170 6e-43 5LPV-A nrPDB 170 8e-43 6J5U-C nrPDB 170 1e-42 1PY5-A nrPDB 169 1e-42 6FER-A nrPDB 169 2e-42 2PMN-X nrPDB 169 2e-42 5WNL-A nrPDB 168 2e-42 3MDY-A nrPDB 168 3e-42 4JLC-A nrPDB 167 6e-42 4EUU-A nrPDB 167 8e-42 4F0G-A nrPDB 167 9e-42 3MY0-A nrPDB 166 2e-41 4EUT-A nrPDB 165 2e-41 4G3E-A nrPDB 165 4e-41 2Y4I-B nrPDB 164 5e-41 5XD6-A nrPDB 164 7e-41 3SOC-A nrPDB 163 8e-41 3ZZW-A nrPDB 163 8e-41 6O8B-A nrPDB 162 2e-40 6NT9-A nrPDB 162 2e-40 5TE0-A nrPDB 162 2e-40 3QD2-B nrPDB 162 3e-40 4FL3-A nrPDB 161 4e-40 3UIM-A nrPDB 161 4e-40 5IKW-A nrPDB 160 1e-39 4F9B-A nrPDB 160 1e-39 2QKW-B nrPDB 159 1e-39 5C26-A nrPDB 158 3e-39 5WNO-A nrPDB 156 1e-38 4M66-A nrPDB 156 2e-38 3G2F-A nrPDB 155 3e-38 5CEK-A nrPDB 154 5e-38 6DC0-A nrPDB 154 5e-38 5VC6-A nrPDB 153 9e-38 2H34-A nrPDB 153 2e-37 5E8V-A nrPDB 152 2e-37 5VDK-A nrPDB 152 2e-37 5AR8-A nrPDB 150 8e-37 4LQP-A nrPDB 148 3e-36 4TN6-A nrPDB 148 3e-36 2CHL-A nrPDB 147 8e-36 3SV0-A nrPDB 146 1e-35 4BTK-A nrPDB 145 2e-35 2QLU-A nrPDB 145 2e-35 3LMG-A nrPDB 145 2e-35 4NFN-A nrPDB 144 5e-35 5J0A-A nrPDB 143 8e-35 5L2Q-C nrPDB 141 4e-34 5FQD-C nrPDB 141 5e-34 2C47-A nrPDB 140 6e-34 2CMW-A nrPDB 139 1e-33 4M69-B nrPDB 138 3e-33 4BTF-A nrPDB 138 3e-33 4NT4-A nrPDB 135 4e-32 4XHH-A nrPDB 130 1e-30 4XHL-A nrPDB 128 3e-30 3VHK-A nrPDB 128 3e-30 3HNG-A nrPDB 128 4e-30 4JRN-A nrPDB 127 9e-30 4RT7-A nrPDB 126 1e-29 4L68-A nrPDB 123 1e-28 2PZI-A nrPDB 121 4e-28 4Y12-A nrPDB 121 5e-28 5X1R-A nrPDB 119 2e-27 5CLR-A nrPDB 102 2e-22 4IX6-A nrPDB 92 4e-19 4CI6-B nrPDB 89 3e-18 Sequences not found previously or not previously below threshold: 3AOX-A nrPDB 165 4e-41 6BFN-A nrPDB 146 2e-35 5X18-A nrPDB 128 5e-30 4MWI-A nrPDB 125 3e-29 1CSN-A nrPDB 120 1e-27 5USZ-A nrPDB 108 3e-24 4L00-A nrPDB 108 5e-24 5UV4-A nrPDB 107 8e-24 3REP-A nrPDB 105 3e-23 5M07-A nrPDB 104 5e-23 5OAT-A nrPDB 103 9e-23 6EQI-C nrPDB 101 4e-22 5C01-A nrPDB 101 7e-22 4WOV-A nrPDB 100 1e-21 4I94-A nrPDB 94 1e-19 6J6I-B nrPDB 87 9e-18 5UU1-A nrPDB 86 2e-17 2RSV-A nrPDB 79 3e-15 2LAV-A nrPDB 78 6e-15 6G4J-A nrPDB 68 5e-12 4OAU-C nrPDB 68 5e-12 4O1O-A nrPDB 67 1e-11 6M7Z-A nrPDB 64 8e-11 2JII-A nrPDB 63 1e-10 5DMZ-A nrPDB 62 4e-10 4CYJ-A nrPDB 60 2e-09 3ENH-A nrPDB 58 5e-09 6EWX-A nrPDB 58 6e-09 6EAS-A nrPDB 56 3e-08 6G38-A nrPDB 55 4e-08 4AZV-A nrPDB 54 1e-07 4AZW-A nrPDB 54 1e-07 6BHC-A nrPDB 53 2e-07 5VE6-A nrPDB 53 3e-07 5GZA-A nrPDB 51 5e-07 5GZ9-A nrPDB 51 9e-07 4WWA-A nrPDB 50 2e-06 2W1Z-A nrPDB 48 8e-06 4BWP-A nrPDB 47 1e-05 3BYV-A nrPDB 46 3e-05 3Q60-A nrPDB 45 6e-05 4CZY-B nrPDB 45 7e-05 6R5K-O nrPDB 44 1e-04 3DZO-A nrPDB 43 3e-04 4XR7-L nrPDB 42 3e-04 1TQM-A nrPDB 42 4e-04 5YK0-A nrPDB 41 9e-04 6FAI-l nrPDB 35 0.044 6G18-v nrPDB 34 0.090 6FDN-A nrPDB 33 0.15 5N28-B nrPDB 33 0.17 4BVU-A nrPDB 32 0.33 4ESA-B nrPDB 32 0.40 2Q0V-A nrPDB 32 0.52 >4EWQ-A nrPDB Length = 383 Score = 535 bits (1379), Expect = e-152, Method: Composition-based stats. Identities = 359/359 (100%), Positives = 359/359 (100%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS Sbjct: 25 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 84 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK Sbjct: 85 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 144 Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG 181 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG Sbjct: 145 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG 204 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGT 241 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGT Sbjct: 205 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGT 264 Query: 242 PGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQ 301 PGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQ Sbjct: 265 PGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQ 324 Query: 302 ALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES 360 ALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES Sbjct: 325 ALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES 383 >3OHT-A nrPDB Length = 389 Score = 514 bits (1323), Expect = e-146, Method: Composition-based stats. Identities = 309/358 (86%), Positives = 333/358 (93%) Query: 3 QERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSI 62 +ERPTFYRQELNKTIWEVPERYQ LSPVGSGAYGSVC+++D K+GL++AVKKLSRPFQSI Sbjct: 32 KERPTFYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSI 91 Query: 63 IHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL 122 IHAKRTYRELRLLKHMKHENVIGLLDVFTPA SLEEFNDVYLVTHLMGADLNNIVKCQKL Sbjct: 92 IHAKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKL 151 Query: 123 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY 182 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY Sbjct: 152 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY 211 Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 242 VATRWYRAPEIMLNWMHYN TVDIWSVGCIMAELLTGRTLFPGTDHI+QL+ I+RL GTP Sbjct: 212 VATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTP 271 Query: 243 GAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQA 302 A ++ ++ S ARNYI SL QMPK NFA+VFIGANPLAVDLLEKMLVLD+DKRITA++A Sbjct: 272 PASVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEA 331 Query: 303 LAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES 360 LAH YF+QYHDPDDEP ++PYDQSFESR L I+EWK LTY+EV SF PP D +EMES Sbjct: 332 LAHPYFSQYHDPDDEPESEPYDQSFESRQLEIEEWKRLTYEEVCSFETPPFDGDEMES 389 >3GC9-A nrPDB Length = 370 Score = 467 bits (1202), Expect = e-132, Method: Composition-based stats. Identities = 261/348 (75%), Positives = 308/348 (88%) Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60 MS R FYRQELNKT+WEVP+R Q L PVGSGAYGSVC+A+D + +VAVKKLSRPFQ Sbjct: 7 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 66 Query: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120 S+IHA+RTYRELRLLKH+KHENVIGLLDVFTPA S+E+F++VYLVT LMGADLNNIVK Q Sbjct: 67 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQ 126 Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180 L+D+HVQFL+YQ+LRGLKYIHSA IIHRDLKPSN+AVNED EL+ILDFGLAR D+EMT Sbjct: 127 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMT 186 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL G+ LFPG+D+IDQLK I+ +VG Sbjct: 187 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 246 Query: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300 TP E+L KISSE AR YIQSL MP+ + +++F GANPLA+DLL +MLVLDSD+R++AA Sbjct: 247 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 306 Query: 301 QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISF 348 +ALAHAYF+QYHDP+DEP A+PYD+S E+++ ++EWK LTY EV+SF Sbjct: 307 EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSF 354 >1CM8-A nrPDB Length = 367 Score = 448 bits (1154), Expect = e-126, Method: Composition-based stats. Identities = 223/354 (62%), Positives = 281/354 (79%), Gaps = 3/354 (0%) Query: 1 MSQE---RPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR 57 MS R FYRQE+ KT WEV Y++L PVGSGAYG+VC+A D +TG +VA+KKL R Sbjct: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 Query: 58 PFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV 117 PFQS + AKR YRELRLLKHM+HENVIGLLDVFTP +L++F D YLV MG DL ++ Sbjct: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120 Query: 118 KCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD 177 K +KL +D +QFL+YQ+L+GL+YIH+A IIHRDLKP NLAVNEDCELKILDFGLAR D Sbjct: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180 Query: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 EMTGYV TRWYRAPE++LNWM Y QTVDIWSVGCIMAE++TG+TLF G+DH+DQLK I++ Sbjct: 181 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 Query: 238 LVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI 297 + GTP AE ++++ S+ A+NY++ L ++ K +FA++ A+PLAV+LLEKMLVLD+++R+ Sbjct: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 Query: 298 TAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPP 351 TA +ALAH YF HD +DEP YD SF+ D +DEWK +TY EV+SF PP Sbjct: 301 TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354 >4MYG-A nrPDB Length = 372 Score = 426 bits (1095), Expect = e-120, Method: Composition-based stats. Identities = 214/348 (61%), Positives = 271/348 (77%), Gaps = 2/348 (0%) Query: 4 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII 63 + FY+Q++NKT WE+P+ Y + + VGSGAYGSVC+A D ++G +VA+KKLSRPFQS I Sbjct: 25 RKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 84 Query: 64 HAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLT 123 AKR YREL LLKHM+HENVIGLLDVFTPA SL F D YLV M DL I+ + + Sbjct: 85 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-GMEFS 143 Query: 124 DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV 183 ++ +Q+L+YQ+L+GLKYIHSA ++HRDLKP NLAVNEDCELKILDFGLARH D EMTGYV Sbjct: 144 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYV 203 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPG 243 TRWYRAPE++L+WMHYNQTVDIWSVGCIMAE+LTG+TLF G D++DQL IL++ G PG Sbjct: 204 VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 263 Query: 244 AELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQAL 303 E ++K++ ++A++YIQSL Q P+ +F +F A+P A DLLEKML LD DKR+TAAQAL Sbjct: 264 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 323 Query: 304 AHAYFAQYHDPDDEPVA-DPYDQSFESRDLLIDEWKSLTYDEVISFVP 350 H +F + DP++E A P+D S E L +DEWK Y E+++F P Sbjct: 324 THPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 371 >4QTB-A nrPDB Length = 380 Score = 385 bits (990), Expect = e-107, Method: Composition-based stats. Identities = 169/349 (48%), Positives = 234/349 (67%), Gaps = 9/349 (2%) Query: 13 LNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYREL 72 + ++V RY L +G GAYG V +A+D RVA+KK+S PF+ + +RT RE+ Sbjct: 32 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 90 Query: 73 RLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIY 132 ++L +HENVIG+ D+ A +LE DVY+V LM DL ++K Q+L++DH+ + +Y Sbjct: 91 QILLRFRHENVIGIRDI-LRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 149 Query: 133 QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATR 186 QILRGLKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D E +T YVATR Sbjct: 150 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 209 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 WYRAPEIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P E Sbjct: 210 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 269 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHA 306 L I + ARNY+QSL K+ +A +F ++ A+DLL++ML + +KRIT +ALAH Sbjct: 270 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHP 329 Query: 307 YFAQYHDPDDEPVA-DPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLD 354 Y QY+DP DEPVA +P+ + E DL + K L + E F P L+ Sbjct: 330 YLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLE 378 >5AWM-A nrPDB Length = 394 Score = 385 bits (990), Expect = e-107, Method: Composition-based stats. Identities = 170/366 (46%), Positives = 236/366 (64%), Gaps = 20/366 (5%) Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60 M+ + Y E+ T + + RY NL P+GSGA G VCAA+DT T VA+KKLSRPFQ Sbjct: 23 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ 82 Query: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120 ++ HAKR YRE +L+K + H+N+IGLL+ FTP R+LEEF DVYLV LM A+L +++ Sbjct: 83 NVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM- 141 Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-- 178 L D + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR Sbjct: 142 DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM 201 Query: 179 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL 238 MT YV TR+YRAPE++L M Y + VDIWSVGCIM E++ G LFPGTDHIDQ I+ Sbjct: 202 MTPYVVTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 260 Query: 239 VGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIG-------------ANPLAVDLL 285 +GTP ++++ + RNY+++ + +F +F A +LL Sbjct: 261 LGTPSPSFMQRLQ-PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLL 319 Query: 286 EKMLVLDSDKRITAAQALAHAYFAQYHDPD--DEPVADPYDQSFESRDLLIDEWKSLTYD 343 KMLV+D ++RI+ +AL H Y ++D + D P +PYD S + R+ +++WK L Y+ Sbjct: 320 SKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYE 379 Query: 344 EVISFV 349 EV+ + Sbjct: 380 EVMDYE 385 >5NGU-A nrPDB Length = 381 Score = 381 bits (978), Expect = e-106, Method: Composition-based stats. Identities = 167/346 (48%), Positives = 234/346 (67%), Gaps = 9/346 (2%) Query: 13 LNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYREL 72 + +++V RY NLS +G GAYG VC+A+D +RVA+KK+S PF+ + +RT RE+ Sbjct: 33 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLREI 91 Query: 73 RLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIY 132 ++L +HEN+IG+ D+ A ++E+ DVY+V LM DL ++K Q L++DH+ + +Y Sbjct: 92 KILLRFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 150 Query: 133 QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATR 186 QILRGLKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D + +T YVATR Sbjct: 151 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 210 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 WYRAPEIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P E Sbjct: 211 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 270 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHA 306 L I + ARNY+ SL K+ + +F A+ A+DLL+KML + KRI QALAH Sbjct: 271 LNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHP 330 Query: 307 YFAQYHDPDDEPVAD-PYDQSFESRDLLIDEWKSLTYDEVISFVPP 351 Y QY+DP DEP+A+ P+ E DL ++ K L ++E F P Sbjct: 331 YLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPG 376 >1JNK-A nrPDB Length = 423 Score = 378 bits (970), Expect = e-105, Method: Composition-based stats. Identities = 170/364 (46%), Positives = 231/364 (63%), Gaps = 19/364 (5%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ Sbjct: 42 SKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQN 101 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 HAKR YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV LM A+L +++ + Sbjct: 102 QTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME- 160 Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--M 179 L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR M Sbjct: 161 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 220 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239 T YV TR+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG D+IDQ ++ + Sbjct: 221 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQL 279 Query: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIG------------ANPLAVDLLEK 287 GTP E +KK+ + RNY+++ + + F +F A DLL K Sbjct: 280 GTPCPEFMKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 Query: 288 MLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEV 345 MLV+D KRI+ AL H Y ++DP + P YD+ + R+ I+EWK L Y EV Sbjct: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 Query: 346 ISFV 349 ++ Sbjct: 399 MNSE 402 >4IC8-A nrPDB Length = 442 Score = 377 bits (969), Expect = e-105, Method: Composition-based stats. Identities = 158/343 (46%), Positives = 222/343 (64%), Gaps = 9/343 (2%) Query: 15 KTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRL 74 ++V + Y+ + +G+GAYG V +A TG +VA+KK+ F + +AKRT REL++ Sbjct: 48 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 107 Query: 75 LKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQ 133 LKH KH+N+I + D+ P EF VY+V LM +DL+ I+ Q LT +HV++ +YQ Sbjct: 108 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 167 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-------DDEMTGYVATR 186 +LRGLKY+HSA +IHRDLKPSNL VNE+CELKI DFG+AR MT YVATR Sbjct: 168 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 227 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 WYRAPE+ML+ Y Q +D+WSVGCI E+L R LFPG +++ QL+LI+ ++GTP + Sbjct: 228 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 287 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHA 306 ++ + +E R YIQSL + + V+ GA+ A+ LL +ML + RI+AA AL H Sbjct: 288 IQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHP 347 Query: 307 YFAQYHDPDDEP-VADPYDQSFESRDLLIDEWKSLTYDEVISF 348 + A+YHDPDDEP A P+D +F+ L + K E+ F Sbjct: 348 FLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 390 >2XS0-A nrPDB Length = 386 Score = 376 bits (965), Expect = e-104, Method: Composition-based stats. Identities = 170/364 (46%), Positives = 231/364 (63%), Gaps = 19/364 (5%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ Sbjct: 6 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 65 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V LM A+L +++ + Sbjct: 66 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME- 124 Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--M 179 L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR M Sbjct: 125 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 184 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239 +V TR+YRAPE++L M Y + VDIWSVGCIM E++ G LFPGTDHIDQ ++ + Sbjct: 185 VPFVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 243 Query: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGA------------NPLAVDLLEK 287 GTP E +KK+ + R Y+++ + +F +F A DLL K Sbjct: 244 GTPCPEFMKKLQ-PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 302 Query: 288 MLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPY--DQSFESRDLLIDEWKSLTYDEV 345 MLV+D+ KRI+ +AL H Y ++DP + P D+ + R+ I+EWK L Y EV Sbjct: 303 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 362 Query: 346 ISFV 349 + Sbjct: 363 MDLE 366 >4ZSG-A nrPDB Length = 347 Score = 374 bits (960), Expect = e-104, Method: Composition-based stats. Identities = 158/342 (46%), Positives = 222/342 (64%), Gaps = 9/342 (2%) Query: 16 TIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLL 75 ++V + Y+ + +G+GAYG V +A TG +VA+KK+ F + +AKRT REL++L Sbjct: 1 VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKIL 60 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQI 134 KH KH+N+I + D+ P EF VY+V LM +DL+ I+ Q LT +HV++ +YQ+ Sbjct: 61 KHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQL 120 Query: 135 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-------DDEMTGYVATRW 187 LRGLKY+HSA +IHRDLKPSNL VNE+CELKI DFG+AR MT YVATRW Sbjct: 121 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 180 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247 YRAPE+ML+ Y Q +D+WSVGCI E+L R LFPG +++ QL+LI+ ++GTP ++ Sbjct: 181 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 240 Query: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 + + +E R YIQSL + + V+ GA+ A+ LL +ML + RI+AA AL H + Sbjct: 241 QAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPF 300 Query: 308 FAQYHDPDDEP-VADPYDQSFESRDLLIDEWKSLTYDEVISF 348 A+YHDPDDEP A P+D +F+ L + K E+ F Sbjct: 301 LAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 342 >3E7O-A nrPDB Length = 360 Score = 373 bits (959), Expect = e-104, Method: Composition-based stats. Identities = 177/362 (48%), Positives = 230/362 (63%), Gaps = 19/362 (5%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ Sbjct: 2 SHMDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQN 61 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 HAKR YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ + Sbjct: 62 QTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME- 120 Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--M 179 L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR M Sbjct: 121 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMM 180 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239 T YV TR+YRAPE++L M Y + VDIWSVGCIM EL+ G +F GTDHIDQ ++ + Sbjct: 181 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQL 239 Query: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIG------------ANPLAVDLLEK 287 GTP AE + + + RNY+++ P + F +F A DLL K Sbjct: 240 GTPSAEFMAALQ-PTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSK 298 Query: 288 MLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEV 345 MLV+D DKRI+ +AL H Y ++DP + P YD E R+ I+EWK L Y EV Sbjct: 299 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 358 Query: 346 IS 347 + Sbjct: 359 MD 360 >6DTL-A nrPDB Length = 364 Score = 373 bits (959), Expect = e-104, Method: Composition-based stats. Identities = 161/348 (46%), Positives = 229/348 (65%), Gaps = 7/348 (2%) Query: 8 FYRQELNKTIWEVPERYQN-LSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK 66 F + + I+EV +Y+ + P+G GAYG VC+A +++T VA+KK++ F + I AK Sbjct: 15 FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK 74 Query: 67 RTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDD 125 RT RE++LL+HM HEN++ + D+ P FNDVY+ LM DL+ I++ + L+++ Sbjct: 75 RTLREIKLLRHMDHENIVAIRDIIPPPLR-NAFNDVYIAYELMDTDLHQIIRSNQALSEE 133 Query: 126 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD--DEMTGYV 183 H Q+ +YQILRGLKYIHSA+++HRDLKPSNL +N +C+LKI DFGLAR T D MT YV Sbjct: 134 HCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYV 193 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPG 243 TRWYRAPE++LN Y +D+WSVGCI EL+ + LFPG DH+ QL+L++ L+GTP Sbjct: 194 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS 253 Query: 244 AELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQAL 303 + +E+A+ YI+ L P+ + + F +PLA+DL+EKML D +RIT AL Sbjct: 254 E-EELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 312 Query: 304 AHAYFAQYHDPDDEP-VADPYDQSFESRDLLIDEWKSLTYDEVISFVP 350 AH Y HD DEP P++ FE+ L ++ K L Y E ++F P Sbjct: 313 AHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNP 360 >2F9G-A nrPDB Length = 353 Score = 370 bits (949), Expect = e-103, Method: Composition-based stats. Identities = 157/350 (44%), Positives = 215/350 (61%), Gaps = 21/350 (6%) Query: 17 IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 ++ + +Q S +G GAYG VC+A TG VA+KK+ PF + A RT RE+++LK Sbjct: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILK 64 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILR 136 H KHEN+I + ++ P S E FN+VY++ LM DL+ ++ Q L+DDH+Q+ IYQ LR Sbjct: 65 HFKHENIITIFNIQRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLR 123 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------------MTGYV 183 +K +H +++IHRDLKPSNL +N +C+LK+ DFGLAR D+ MT YV Sbjct: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP- 242 ATRWYRAPE+ML Y++ +D+WS GCI+AEL R +FPG D+ QL LI ++GTP Sbjct: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 Query: 243 GAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQA 302 L+ I S AR YI+SL P +F NP +DLL++MLV D KRITA +A Sbjct: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 Query: 303 LAHAYFAQYHDPDDEPVADPYDQSFESRDL-----LIDEWKSLTYDEVIS 347 L H Y YHDP+DEP +P SF D + K L ++E+ S Sbjct: 304 LEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 >5Z33-A nrPDB Length = 425 Score = 365 bits (936), Expect = e-101, Method: Composition-based stats. Identities = 163/339 (48%), Positives = 209/339 (61%), Gaps = 13/339 (3%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 V ERY +G GAYG VCAA + +T VA+KK++ F I AKR RE++LL+H + Sbjct: 29 VDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFR 88 Query: 80 -HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQILRG 137 H N+ L D + FN+ YL LM DL I++ Q LTD H Q IYQIL G Sbjct: 89 GHRNITCLYD--MDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCG 146 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYRA 190 LKYIHSA+++HRDLKP NL VN DCELKI DFGLAR + MT YVATRWYRA Sbjct: 147 LKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRA 206 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250 PEIML++ Y + +D+WSVGCI+AELL GR F G D++DQL IL ++GTP E L +I Sbjct: 207 PEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRI 266 Query: 251 SSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 S A+ Y+++L M K F +F ANP A+DLL++ML D RI+ QAL H Y Sbjct: 267 GSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYLHI 326 Query: 311 YHDPDDEP-VADPYDQSFESRDLLIDEWKSLTYDEVISF 348 +HD DEP ++ FE + + E + + DEV F Sbjct: 327 WHDASDEPDCPTTFNFDFEVVE-DVGEMRKMILDEVYRF 364 >3FI2-A nrPDB Length = 353 Score = 359 bits (921), Expect = 1e-99, Method: Composition-based stats. Identities = 165/362 (45%), Positives = 224/362 (61%), Gaps = 26/362 (7%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ Sbjct: 4 SKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQN 63 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 HAKR YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV LM A+L +++ + Sbjct: 64 QTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME- 122 Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--M 179 L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR M Sbjct: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239 T YV TR+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG D+IDQ ++ + Sbjct: 183 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQL 241 Query: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIG------------ANPLAVDLLEK 287 GTP E +KK+ + RNY+++ + + F +F A DLL K Sbjct: 242 GTPCPEFMKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 300 Query: 288 MLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVIS 347 MLV+D KRI+ AL H Y ++ + R+ I+EWK L Y EV++ Sbjct: 301 MLVIDPAKRISVDDALQHPYINVWYX---------XXXXXDEREHTIEEWKELIYKEVMN 351 Query: 348 FV 349 Sbjct: 352 SE 353 >4QNY-A nrPDB Length = 354 Score = 343 bits (880), Expect = 7e-95, Method: Composition-based stats. Identities = 132/343 (38%), Positives = 207/343 (60%), Gaps = 7/343 (2%) Query: 12 ELNKTIWEVPERYQNLSPVGSGAYGSVCAAFD-TKTGLRVAVKKLSRP-FQSIIHAKRTY 69 EL + + +RY +G+G+YG V A D VA+K++++ F+ +I AKR Sbjct: 10 ELQAEVCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRIL 69 Query: 70 RELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQ 128 RE++LL H +N+IGL ++ TP E F+ Y+V +M DL +++ Q+LT+ H+Q Sbjct: 70 REIKLLAHFNDDNIIGLRNILTPEDP-ENFDHFYIVMDIMETDLKQVLRSGQELTEAHIQ 128 Query: 129 FLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVAT 185 F IYQ LR L IHSA +IHRD+ P+N+ VN +C+LKI DFGLA+ +D+ MT YV Sbjct: 129 FFIYQALRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTM 188 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 RWYRAPE+++ Y+ +D+W +GCI+ ELL R LF G D ++QL I+ ++GTP E Sbjct: 189 RWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEE 248 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAH 305 + + S +A+ Y++ + P+ ++ + A+P A+DLL MLV + +RIT QA+ H Sbjct: 249 DINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRH 308 Query: 306 AYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISF 348 + Q HD D+ ++ + E+ I + K Y+E + F Sbjct: 309 PFLEQLHDDADDNLSYALFRFDENEQKTIVDVKRAIYEESVKF 351 >3OZ6-A nrPDB Length = 388 Score = 334 bits (858), Expect = 2e-92, Method: Composition-based stats. Identities = 128/372 (34%), Positives = 213/372 (57%), Gaps = 47/372 (12%) Query: 19 EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 V +Y+ + +G GAYG V + D +TG VAVKK+ FQ+ A+RT+RE+ +L + Sbjct: 6 HVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTEL 65 Query: 79 K-HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 137 HEN++ LL+V DVYLV M DL+ +++ L H Q+++YQ+++ Sbjct: 66 SGHENIVNLLNVLRAD----NDRDVYLVFDYMETDLHAVIRANILEPVHKQYVVYQLIKV 121 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---------------------HTD 176 +KY+HS ++HRD+KPSN+ +N +C +K+ DFGL+R + D Sbjct: 122 IKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFD 181 Query: 177 DE---MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLK 233 D+ +T YVATRWYRAPEI+L Y + +D+WS+GCI+ E+L G+ +FPG+ ++QL+ Sbjct: 182 DDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLE 241 Query: 234 LILRLVGTPGAELLKKISSESARNYIQSLTQMPKM----------NFANVFIGANP---- 279 I+ ++ P E ++ I S A+ I+SL + ++ + N+ + NP Sbjct: 242 RIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADC 301 Query: 280 --LAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSF--ESRDLLID 335 A+DLL+K+L + +KRI+A AL H + + +H+P++EP D ++ ID Sbjct: 302 NEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPINDNVKHSID 361 Query: 336 EWKSLTYDEVIS 347 ++++L Y E+ Sbjct: 362 DYRNLVYSEISR 373 >2BPM-A nrPDB Length = 309 Score = 333 bits (855), Expect = 5e-92, Method: Composition-based stats. Identities = 112/301 (37%), Positives = 161/301 (53%), Gaps = 14/301 (4%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E +Q + +G G YG V A + TG VA+KK+ ++ RE+ LLK + H Sbjct: 7 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 66 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLT---DDHVQFLIYQILRGL 138 N++ LLDV N +YLV + DL + LT ++ ++Q+L+GL Sbjct: 67 NIVKLLDVIHTE------NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 120 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEIML 195 + HS ++HRDLKP NL +N + +K+ DFGLAR + Y V T WYRAPEI+L Sbjct: 121 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 180 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 +Y+ VDIWS+GCI AE++T R LFPG IDQL I R +GTP + ++S Sbjct: 181 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM-- 238 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPD 315 +Y S + + +F+ V + LL +ML D +KRI+A ALAH +F P Sbjct: 239 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 298 Query: 316 D 316 Sbjct: 299 P 299 >4O2Z-A nrPDB Length = 377 Score = 330 bits (847), Expect = 5e-91, Method: Composition-based stats. Identities = 142/376 (37%), Positives = 216/376 (57%), Gaps = 33/376 (8%) Query: 2 SQERPTFYRQ-----------------ELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDT 44 S R Y Q ++ + +EVP +Y L +G GAYG C+ D Sbjct: 8 SSGRENLYFQGNQELSVPKIVGDFKVYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDG 67 Query: 45 KTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTP-ARSLEEFNDVY 103 TG +V++KK F+ + KR RE+ +++ HEN++ ++++ P R F DVY Sbjct: 68 DTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVY 127 Query: 104 LVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC 162 +VT LM D+N +++ ++ L + H+Q+ +YQILRGLKY+HSA++ HRDLKP+NL N C Sbjct: 128 VVTPLMDVDMNVVLRSRQVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISC 187 Query: 163 ELKILDFGLARHTD---DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTG 219 ELKI+DFGL+R D E+T YV TRWYR PE++L +Y+ VDIWSVGCI AE+ Sbjct: 188 ELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNR 247 Query: 220 RTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP--KMNFANVFIGA 277 + +FPG + +DQL++I + +G P A +++ R ++ L ++P +N + G Sbjct: 248 KPVFPGRNTMDQLRMIAQHIGKPPASIVEH------REALEKLNELPDGSLNIPKLVPGL 301 Query: 278 --NPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAD-PYDQSFESRDLLI 334 N +D L KM LD KR TAA LAH Y A HD +DEP P+ + ES + + Sbjct: 302 AGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHDEEDEPTCPCPFLWAHESTPMGV 361 Query: 335 DEWKSLTYDEVISFVP 350 E + + +++ + P Sbjct: 362 SELRRAFWADIVDYNP 377 >3NIZ-A nrPDB Length = 311 Score = 328 bits (842), Expect = 2e-90, Method: Composition-based stats. Identities = 116/319 (36%), Positives = 164/319 (51%), Gaps = 21/319 (6%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S R Y Q L E+YQ L VG G YG V A D++ G VA+K++ + Sbjct: 8 SSGRENLYFQGL-------MEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAED 59 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 RE+ LLK + H N++ L+DV R L LV M DL ++ K Sbjct: 60 EGIPSTAIREISLLKELHHPNIVSLIDVIHSERCLT------LVFEFMEKDLKKVLDENK 113 Query: 122 --LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM 179 L D ++ +YQ+LRG+ + H I+HRDLKP NL +N D LK+ DFGLAR + Sbjct: 114 TGLQDSQIKIYLYQLLRGVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPV 173 Query: 180 TGY---VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 Y V T WYRAP++++ Y+ +VDIWS+GCI AE++TG+ LFPG DQL I Sbjct: 174 RSYTHEVVTLWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIF 233 Query: 237 RLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKR 296 ++GTP ++ ++ K ++++ G +DLL ML D +KR Sbjct: 234 SILGTPNPREWPQVQELPLWK-QRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKR 292 Query: 297 ITAAQALAHAYFAQYHDPD 315 I+A A+ H YF DP Sbjct: 293 ISARDAMNHPYFKDL-DPQ 310 >6GU6-A nrPDB Length = 302 Score = 314 bits (805), Expect = 4e-86, Method: Composition-based stats. Identities = 105/299 (35%), Positives = 156/299 (52%), Gaps = 15/299 (5%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E Y + +G G YG V TG VA+KK+ + RE+ LLK ++H Sbjct: 7 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 66 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC----QKLTDDHVQFLIYQILRG 137 N++ L DV L + + +YL+ + DL + Q + V+ +YQIL+G Sbjct: 67 NIVSLQDV------LMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 120 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEIM 194 + + HS ++HRDLKP NL +++ +K+ DFGLAR + Y V T WYR+PE++ Sbjct: 121 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 180 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 L Y+ VDIWS+G I AEL T + LF G IDQL I R +GTP E+ ++ ES Sbjct: 181 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV--ES 238 Query: 255 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHD 313 ++Y + + + A+ + +DLL KML+ D KRI+ AL H YF + Sbjct: 239 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 297 >3RP9-A nrPDB Length = 458 Score = 313 bits (802), Expect = 9e-86, Method: Composition-based stats. Identities = 127/397 (31%), Positives = 209/397 (52%), Gaps = 65/397 (16%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 W++P+RY+ +G+G+YG VC A+D VA+KK+ R F+ +I KR RE+ +L Sbjct: 49 WQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNR 108 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ-KLTDDHVQFLIYQILR 136 + H++V+ +LD+ P +E+F+++Y+V + +D + + LT+ H++ L+Y +L Sbjct: 109 LNHDHVVKVLDIVIPKD-VEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNLLV 167 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD-------------------- 176 G+KY+HSA I+HRDLKP+N VN+DC +K+ DFGLAR D Sbjct: 168 GVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNL 227 Query: 177 ----------DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-------- 218 ++TG+V TRWYRAPE++L +Y + +D+WS+GCI AELL Sbjct: 228 VTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAY 287 Query: 219 ---GRTLFPGTD--------------------HIDQLKLILRLVGTPGAELLKKISSESA 255 LFPG+ + DQL +I ++GTP E ++ + E A Sbjct: 288 HADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDA 347 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPD 315 + YI+ + + A F ++ A+ LL++MLV + +KRIT + LAH +F + + Sbjct: 348 KRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVRIAE 407 Query: 316 DEPVADPYDQSFESRDLLIDE--WKSLTYDEVISFVP 350 E A + + + +DE + E+ + P Sbjct: 408 VETNATEKVRLPFNDWMNMDEPQLRYAFVKEIQRYHP 444 >4AU8-A nrPDB Length = 296 Score = 309 bits (793), Expect = 9e-85, Method: Composition-based stats. Identities = 106/300 (35%), Positives = 156/300 (52%), Gaps = 14/300 (4%) Query: 21 PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH 80 ++Y+ L +G G YG+V A + +T VA+K++ RE+ LLK +KH Sbjct: 5 SQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 64 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC--QKLTDDHVQFLIYQILRGL 138 +N++ L DV + L LV DL L + V+ ++Q+L+GL Sbjct: 65 KNIVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 118 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEIML 195 + HS +++HRDLKP NL +N + ELK+ DFGLAR + Y V T WYR P+++ Sbjct: 119 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 178 Query: 196 NWMHYNQTVDIWSVGCIMAELL-TGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 Y+ ++D+WS GCI AEL GR LFPG D DQLK I RL+GTP E ++ Sbjct: 179 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK-- 236 Query: 255 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 314 +Y + NV N DLL+ +L + +RI+A +AL H YF+ + P Sbjct: 237 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 296 >4KRC-A nrPDB Length = 317 Score = 309 bits (791), Expect = 1e-84, Method: Composition-based stats. Identities = 103/305 (33%), Positives = 165/305 (54%), Gaps = 24/305 (7%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 +++ L +G+G Y +V + TG+ VA+K++ + RE+ L+K +KHEN Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGT-PSTAIREISLMKELKHEN 64 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ-------KLTDDHVQFLIYQIL 135 ++ L DV N + LV M DL + + L + V++ +Q+L Sbjct: 65 IVRLYDVIHTE------NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPE 192 +GL + H I+HRDLKP NL +N+ +LK+ DFGLAR + + V T WYRAP+ Sbjct: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 +++ Y+ ++DIWS GCI+AE++TG+ LFPGT+ +QLKLI ++GTP L ++ Sbjct: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPL-----AVDLLEKMLVLDSDKRITAAQALAHAY 307 Y ++ Q P + V +D L +L L+ D R++A QAL H + Sbjct: 239 --LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 Query: 308 FAQYH 312 FA+Y+ Sbjct: 297 FAEYY 301 >3N9X-A nrPDB Length = 432 Score = 308 bits (789), Expect = 3e-84, Method: Composition-based stats. Identities = 127/405 (31%), Positives = 194/405 (47%), Gaps = 59/405 (14%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S R Y Q + VP+ Y +G G+YG V A+D T VA+KK++R F+ Sbjct: 8 SSGRENLYFQGIKNV--HVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFED 65 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 +I KR RE+ +L +K + +I L D+ P L +F+++Y+V + +DL + K Sbjct: 66 LIDCKRILREITILNRLKSDYIIRLYDLIIPDDLL-KFDELYIVLEIADSDLKKLFKTPI 124 Query: 122 L-TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-- 178 T++H++ ++Y +L G +IH + IIHRDLKP+N +N+DC +K+ DFGLAR + E Sbjct: 125 FLTEEHIKTILYNLLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKD 184 Query: 179 -----------------------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAE 215 +T +V TRWYRAPE++L +Y +++DIWS GCI AE Sbjct: 185 TNIVNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAE 244 Query: 216 LL-----------TGRTLFPGT-----------------DHIDQLKLILRLVGTPGAELL 247 LL LFPG+ + DQL +I ++GTP + L Sbjct: 245 LLNMLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDL 304 Query: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 K I+ YI+ +N + + ++LLE ML + +KRIT QAL H Y Sbjct: 305 KNINKPEVIKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPY 364 Query: 308 FAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVISFVP 350 E + + L + + + EV SF P Sbjct: 365 LKDVRKKKLENFSTKKIILPFDDWMVLSETQLRYIFLKEVQSFHP 409 >1V0B-A nrPDB Length = 288 Score = 306 bits (785), Expect = 8e-84, Method: Composition-based stats. Identities = 109/294 (37%), Positives = 156/294 (53%), Gaps = 14/294 (4%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E+Y L +G G YG V A + G A+KK+ + T RE+ +LK +KH Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELKHS 60 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIYQILRGLK 139 N++ L DV + L LV + DL ++ L + + Q+L G+ Sbjct: 61 NIVKLYDVIHTKKRL------VLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIA 114 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEIMLN 196 Y H ++HRDLKP NL +N + ELKI DFGLAR + Y V T WYRAP++++ Sbjct: 115 YCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMG 174 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 256 Y+ T+DIWSVGCI AE++ G LFPG DQL I R++GTP ++ ++ Sbjct: 175 SKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVT--ELP 232 Query: 257 NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 Y + T + + + G + +DLL KML LD ++RITA QAL HAYF + Sbjct: 233 KYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >3NIE-A nrPDB Length = 429 Score = 304 bits (778), Expect = 5e-83, Method: Composition-based stats. Identities = 127/406 (31%), Positives = 199/406 (49%), Gaps = 60/406 (14%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S R Y Q +VP+ Y+ +G G+YG V A+D VA+KK++R F+ Sbjct: 8 SSGRENLYFQGAIIKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFED 67 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 +I KR RE+ +L +K + +I L D+ P L +F+++Y+V + +DL + K Sbjct: 68 LIDCKRILREITILNRLKSDYIIRLHDLIIPEDLL-KFDELYIVLEIADSDLKKLFKTPI 126 Query: 122 L-TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-- 178 T+ HV+ ++Y +L G K+IH + IIHRDLKP+N +N+DC +KI DFGLAR + + Sbjct: 127 FLTEQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKD 186 Query: 179 --------------------------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCI 212 +T +V TRWYRAPE++L +Y ++DIWS GCI Sbjct: 187 IHIVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCI 246 Query: 213 MAELL-----------TGRTLFPGT-----------------DHIDQLKLILRLVGTPGA 244 AELL LFPG+ + DQL +I ++GTP Sbjct: 247 FAELLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPE 306 Query: 245 ELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304 E LK I+ + YI+ ++ + + + +DLLE ML ++ KRIT +AL+ Sbjct: 307 EDLKCITKQEVIKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALS 366 Query: 305 HAYFAQYHDPDDEP-VADPYDQSFESRDLLID-EWKSLTYDEVISF 348 H Y + E + F+ +L + + + + E+ SF Sbjct: 367 HPYLKDVRKENLENFSTEKIILPFDDWMVLSETQLRYIFLKEIQSF 412 >3PG1-A nrPDB Length = 362 Score = 303 bits (777), Expect = 6e-83, Method: Composition-based stats. Identities = 121/340 (35%), Positives = 185/340 (54%), Gaps = 16/340 (4%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII---------HAKRTYRELRL 74 Y + SG+YG+VCA D++ G+ VA+K++ KR RE+RL Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 75 LKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL--TDDHVQFLIY 132 L H H N++GL D+F + +YLVT LM DL ++ Q++ + H+Q+ +Y Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPA-MHKLYLVTELMRTDLAQVIHDQRIVISPQHIQYFMY 141 Query: 133 QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVATRWYRA 190 IL GL +H A ++HRDL P N+ + ++ ++ I DF LAR D T YV RWYRA Sbjct: 142 HILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYRA 201 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250 PE+++ + + + VD+WS GC+MAE+ + LF G+ +QL I+ +VGTP E + Sbjct: 202 PELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMF 261 Query: 251 SSESARNYIQ-SLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 SS SAR+Y++ SL+ +P + V A+P+A+DL+ KML + +RI+ QAL H YF Sbjct: 262 SSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYFE 321 Query: 310 QYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFV 349 DP D F+ + + + EV F Sbjct: 322 SLFDPLDLTEGLSERFHFDESVTDVYDMHKIFTAEVERFN 361 >3NCG-A nrPDB Length = 486 Score = 303 bits (776), Expect = 8e-83, Method: Composition-based stats. Identities = 88/322 (27%), Positives = 141/322 (43%), Gaps = 48/322 (14%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S R Y Q ERY + +G G++G V D T AVK +++ Sbjct: 8 SSGRENLYFQGT------FAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAK 61 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKC 119 RE+ LLK + H N++ L ++ LE+ + Y+V L G + I+K Sbjct: 62 NKDTSTILREVELLKKLDHPNIMKLFEI------LEDSSSFYIVGELYTGGELFDEIIKR 115 Query: 120 QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV---NEDCELKILDFGLAR--H 174 ++ ++ +I Q+ G+ Y+H +I+HRDLKP N+ + +DC++KI+DFGL+ Sbjct: 116 KRFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQ 175 Query: 175 TDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKL 234 + +M + T +Y APE++ Y++ D+WS G I+ LL+G F G + D LK Sbjct: 176 QNTKMKDRIGTAYYIAPEVLRG--TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKR 233 Query: 235 ILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSD 294 + + I + A DL+ KML Sbjct: 234 VETGKYAFDLPQWRTI---------------------------SDDAKDLIRKMLTFHPS 266 Query: 295 KRITAAQALAHAYFAQYHDPDD 316 RITA Q L H + +Y Sbjct: 267 LRITATQCLEHPWIQKYSSETP 288 >3DFA-A nrPDB Length = 286 Score = 301 bits (771), Expect = 3e-82, Method: Composition-based stats. Identities = 88/318 (27%), Positives = 141/318 (44%), Gaps = 48/318 (15%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S R Y Q ERY + +G G++G V D T AVK +++ Sbjct: 8 SSGRENLYFQGT------FAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAK 61 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKC 119 RE+ LLK + H N++ L ++ LE+ + Y+V L G + I+K Sbjct: 62 NKDTSTILREVELLKKLDHPNIMKLFEI------LEDSSSFYIVGELYTGGELFDEIIKR 115 Query: 120 QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV---NEDCELKILDFGLAR--H 174 ++ ++ +I Q+ G+ Y+H +I+HRDLKP N+ + +DC++KI+DFGL+ Sbjct: 116 KRFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQ 175 Query: 175 TDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKL 234 + +M + T +Y APE++ Y++ D+WS G I+ LL+G F G + D LK Sbjct: 176 QNTKMKDRIGTAYYIAPEVLRG--TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKR 233 Query: 235 ILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSD 294 + + I + A DL+ KML Sbjct: 234 VETGKYAFDLPQWRTI---------------------------SDDAKDLIRKMLTFHPS 266 Query: 295 KRITAAQALAHAYFAQYH 312 RITA Q L H + +Y Sbjct: 267 LRITATQCLEHPWIQKYS 284 >4NST-A nrPDB Length = 351 Score = 299 bits (765), Expect = 2e-81, Method: Composition-based stats. Identities = 101/341 (29%), Positives = 165/341 (48%), Gaps = 13/341 (3%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 +++ + +G G YG V A D TG VA+KK+ + RE+++L+ + H Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR 72 Query: 82 NVIGLLDVFTPARSLEEFND----VYLVTHLMGADLNNIVKCQ--KLTDDHVQFLIYQIL 135 +V+ + ++ T + +F YLV M DL +++ ++DH++ + Q++ Sbjct: 73 SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLM 132 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE----MTGYVATRWYRAP 191 GL+Y H + +HRD+K SN+ +N ++K+ DFGLAR + E T V T WYR P Sbjct: 133 EGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPP 192 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 E++L Y +D+WS GCI+ EL T + +F + QL+LI RL G+P + + Sbjct: 193 ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVI 252 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311 N ++ Q + F A+DLL+ ML LD KR TA Q L + Sbjct: 253 KLPYFNTMKPKKQY-RRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDV 311 Query: 312 HDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPP 352 P P+ Q + +L + + V+ PPP Sbjct: 312 ELSKMAPPDLPHWQ--DCHELWSKKRRRQRQSGVVVEEPPP 350 >3LIJ-A nrPDB Length = 494 Score = 298 bits (763), Expect = 3e-81, Method: Composition-based stats. Identities = 91/337 (27%), Positives = 147/337 (43%), Gaps = 51/337 (15%) Query: 2 SQERPTFYRQE---------LNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAV 52 S R Y Q + + E YQ + +GSGAYG V D T + A+ Sbjct: 8 SSGRENLYFQGDLQATPGMFITSKKGHLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAI 67 Query: 53 KKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--G 110 K + + S + E+ +LK + H N++ L D F E+ + YLV G Sbjct: 68 KIIRKTSVSTSSNSKLLEEVAVLKLLDHPNIMKLYDFF------EDKRNYYLVMECYKGG 121 Query: 111 ADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV---NEDCELKIL 167 + I+ K + +I Q+L G+ Y+H +I+HRDLKP NL + +D +KI+ Sbjct: 122 ELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIV 181 Query: 168 DFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPG 225 DFGL+ +M + T +Y APE++ Y++ D+WS+G I+ LL G F G Sbjct: 182 DFGLSAVFENQKKMKERLGTAYYIAPEVL--RKKYDEKCDVWSIGVILFILLAGYPPFGG 239 Query: 226 TDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLL 285 + L+ + + T + K + + A DL+ Sbjct: 240 QTDQEILRKVEKGKYTFDSPEWKNV---------------------------SEGAKDLI 272 Query: 286 EKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADP 322 ++ML DS +RI+A QAL H + + + + P Sbjct: 273 KQMLQFDSQRRISAQQALEHPWIKEMCSKKESGIELP 309 >3MA6-A nrPDB Length = 298 Score = 297 bits (760), Expect = 7e-81, Method: Composition-based stats. Identities = 90/326 (27%), Positives = 145/326 (44%), Gaps = 47/326 (14%) Query: 2 SQERPTFYRQELNKTIWE----VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR 57 S R Y Q + +RY+ +G G++G V D TG AVK +S+ Sbjct: 8 SSGRENLYFQGPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISK 67 Query: 58 P-FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLN 114 + + RE++LLK + H N++ L + F E+ YLV + G + Sbjct: 68 RQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFF------EDKGYFYLVGEVYTGGELFD 121 Query: 115 NIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV---NEDCELKILDFGL 171 I+ ++ ++ +I Q+L G+ Y+H I+HRDLKP NL + ++D ++I+DFGL Sbjct: 122 EIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGL 181 Query: 172 ARHTD--DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI 229 + H + +M + T +Y APE++ Y++ D+WS G I+ LL+G F G + Sbjct: 182 STHFEASKKMKDKIGTAYYIAPEVLHG--TYDEKCDVWSTGVILYILLSGCPPFNGANEY 239 Query: 230 DQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKML 289 D LK + + T KK+ + A DL+ KML Sbjct: 240 DILKKVEKGKYTFELPQWKKV---------------------------SESAKDLIRKML 272 Query: 290 VLDSDKRITAAQALAHAYFAQYHDPD 315 RI+A AL H + Y Sbjct: 273 TYVPSMRISARDALDHEWIQTYTKEQ 298 >5EFQ-A nrPDB Length = 347 Score = 296 bits (759), Expect = 7e-81, Method: Composition-based stats. Identities = 94/310 (30%), Positives = 153/310 (49%), Gaps = 12/310 (3%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 +++ + +G G YG V A D TG VA+KK+ + RE+++L+ + H+ Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 82 NVIGLLDVFTPARSLEEFND----VYLVTHLMGADLNNIVKCQ--KLTDDHVQFLIYQIL 135 ++I + ++ T +F YLV M DL +++ ++H++ + Q++ Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 130 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE----MTGYVATRWYRAP 191 GL Y H + +HRD+K SN+ +N ++K+ DFGLAR E T V T WYR P Sbjct: 131 EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 190 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 E++L Y +D+WS GCI+ EL T + +F + QL+LI R+ G+P + + Sbjct: 191 ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVI 250 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311 N ++ Q + F+ A+DL + ML LD KR TA QAL + Sbjct: 251 KLPYFNTMKPKKQY-RRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDV 309 Query: 312 HDPDDEPVAD 321 +P P D Sbjct: 310 -EPSKMPPPD 318 >3DXN-A nrPDB Length = 287 Score = 296 bits (759), Expect = 7e-81, Method: Composition-based stats. Identities = 88/319 (27%), Positives = 146/319 (45%), Gaps = 50/319 (15%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP-FQ 60 S R Y Q L+ +RYQ + +GSGAYG V D TG A+K + + Sbjct: 8 SSGRENLYFQGLS-------DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVT 60 Query: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTH-LMGADL-NNIVK 118 + ++ E+ +LK + H N++ L + F E+ + YLV G +L + I+ Sbjct: 61 TTSNSGALLDEVAVLKQLDHPNIMKLYEFF------EDKRNYYLVMEVYRGGELFDEIIL 114 Query: 119 CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV---NEDCELKILDFGLARH- 174 QK ++ ++ Q+L G Y+H +I+HRDLKP NL + + D +KI+DFGL+ H Sbjct: 115 RQKFSEVDAAVIMKQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHF 174 Query: 175 -TDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLK 233 +M + T +Y APE++ Y++ D+WS G I+ LL G F G + LK Sbjct: 175 EVGGKMKERLGTAYYIAPEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILK 232 Query: 234 LILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDS 293 + + + ++ + A L++ ML + Sbjct: 233 RVEKGKFSFDPPDWTQV---------------------------SDEAKQLVKLMLTYEP 265 Query: 294 DKRITAAQALAHAYFAQYH 312 KRI+A +AL H + ++ Sbjct: 266 SKRISAEEALNHPWIVKFC 284 >1UA2-A nrPDB Length = 346 Score = 296 bits (758), Expect = 9e-81, Method: Composition-based stats. Identities = 107/303 (35%), Positives = 159/303 (52%), Gaps = 17/303 (5%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH---AKRTYRELRLLKHM 78 +RY+ L +G G + +V A D T VA+KK+ +S + RE++LL+ + Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL--TDDHVQFLIYQILR 136 H N+IGLLD F +++ LV M DL I+K L T H++ + L+ Sbjct: 70 SHPNIIGLLDAF------GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEI 193 GL+Y+H I+HRDLKP+NL ++E+ LK+ DFGLA+ Y V TRWYRAPE+ Sbjct: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 + Y VD+W+VGCI+AELL PG +DQL I +GTP E + S Sbjct: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS- 242 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHD 313 +Y+ + P + ++F A +DL++ + + + RITA QAL YF+ Sbjct: 243 -LPDYV-TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 Query: 314 PDD 316 P Sbjct: 301 PTP 303 >2I6L-A nrPDB Length = 320 Score = 294 bits (754), Expect = 3e-80, Method: Composition-based stats. Identities = 117/323 (36%), Positives = 186/323 (57%), Gaps = 18/323 (5%) Query: 12 ELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRE 71 +N +++ RY +L P+G G G V +A D RVA+KK+ K RE Sbjct: 1 SMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI--VLTDPQSVKHALRE 58 Query: 72 LRLLKHMKHENVIGLLDVFTPARS--------LEEFNDVYLVTHLMGADLNNIVKCQKLT 123 +++++ + H+N++ + ++ P+ S L E N VY+V M DL N+++ L Sbjct: 59 IKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLL 118 Query: 124 DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLARHTDDEMTGY 182 ++H + +YQ+LRGLKYIHSA+++HRDLKP+NL +N ED LKI DFGLAR D + Sbjct: 119 EEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHK 178 Query: 183 ------VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 + T+WYR+P ++L+ +Y + +D+W+ GCI AE+LTG+TLF G ++Q++LIL Sbjct: 179 GHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLIL 238 Query: 237 RLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKR 296 + E +++ S YI++ P + G + AVD LE++L R Sbjct: 239 ESIPVVHEEDRQELLS-VIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDR 297 Query: 297 ITAAQALAHAYFAQYHDPDDEPV 319 +TA +AL+H Y + Y P DEP+ Sbjct: 298 LTAEEALSHPYMSIYSFPMDEPI 320 >5JN2-A nrPDB Length = 525 Score = 293 bits (751), Expect = 7e-80, Method: Composition-based stats. Identities = 88/318 (27%), Positives = 143/318 (44%), Gaps = 46/318 (14%) Query: 6 PTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP-FQSIIH 64 P + Q +RY+ +G G++G V D TG AVK +S+ + Sbjct: 54 PGMFVQHSTAI---FSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTD 110 Query: 65 AKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKL 122 + RE++LLK + H N++ L + F E+ YLV + G + I+ ++ Sbjct: 111 KESLLREVQLLKQLDHPNIMKLYEFF------EDKGYFYLVGEVYTGGELFDEIISRKRF 164 Query: 123 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV---NEDCELKILDFGLARHTD--D 177 ++ +I Q+L G+ Y+H I+HRDLKP NL + ++D ++I+DFGL+ H + Sbjct: 165 SEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASK 224 Query: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 +M + T +Y APE++ Y++ D+WS G I+ LL+G F G + D LK + + Sbjct: 225 KMKDKIGTAYYIAPEVL--HGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEK 282 Query: 238 LVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI 297 T KK+ + A DL+ KML RI Sbjct: 283 GKYTFELPQWKKV---------------------------SESAKDLIRKMLTYVPSMRI 315 Query: 298 TAAQALAHAYFAQYHDPD 315 +A AL H + Y Sbjct: 316 SARDALDHEWIQTYTKEQ 333 >4BBM-A nrPDB Length = 331 Score = 292 bits (748), Expect = 1e-79, Method: Composition-based stats. Identities = 97/312 (31%), Positives = 156/312 (50%), Gaps = 19/312 (6%) Query: 4 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII 63 Y Q + E+Y+NL VG G+YG V + TG VA+KK + Sbjct: 15 GTENLYFQSM--------EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKM 66 Query: 64 HAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGAD-LNNI-VKCQK 121 K RE++LLK ++HEN++ LL+V + YLV + L+++ + Sbjct: 67 VKKIAMREIKLLKQLRHENLVNLLEVCKKKKRW------YLVFEFVDHTILDDLELFPNG 120 Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT---DDE 178 L VQ ++QI+ G+ + HS +IIHRD+KP N+ V++ +K+ DFG AR + Sbjct: 121 LDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEV 180 Query: 179 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL 238 VATRWYRAPE+++ + Y + VD+W++GC++ E+ G LFPG IDQL I+ Sbjct: 181 YDDEVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMC 240 Query: 239 VGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT 298 +G + + ++ + + + + +DL +K L +D DKR Sbjct: 241 LGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPF 300 Query: 299 AAQALAHAYFAQ 310 A+ L H +F Sbjct: 301 CAELLHHDFFQM 312 >4AGU-A nrPDB Length = 311 Score = 291 bits (745), Expect = 3e-79, Method: Composition-based stats. Identities = 97/313 (30%), Positives = 159/313 (50%), Gaps = 13/313 (4%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E+Y+ + +G G+YG V + TG VA+KK + K RE+R+LK +KH Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGAD-LNNIVKCQK-LTDDHVQFLIYQILRGLK 139 N++ LL+VF R L LV L+ + + Q+ + + V+ + +Q L+ + Sbjct: 63 NLVNLLEVFRRKRRLH------LVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVN 116 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEIMLN 196 + H + IHRD+KP N+ + + +K+ DFG AR Y VATRWYR+PE+++ Sbjct: 117 FCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVG 176 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 256 Y VD+W++GC+ AELL+G L+PG +DQL LI + +G + S+ Sbjct: 177 DTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYF 236 Query: 257 NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDD 316 + ++ F + A+ LL+ L +D +R+T Q L H YF + +D Sbjct: 237 SGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIREIED 296 Query: 317 EPVADPYDQSFES 329 A +D+ E+ Sbjct: 297 L--AKEHDKPAEN 307 >3MIA-A nrPDB Length = 351 Score = 289 bits (739), Expect = 2e-78, Method: Composition-based stats. Identities = 97/319 (30%), Positives = 156/319 (48%), Gaps = 14/319 (4%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 +Y+ L+ +G G +G V A KTG +VA+KK+ + RE+++L+ +KHEN Sbjct: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 Query: 83 VIGLLDVFTPARSLEE--FNDVYLVTHLMGADLNNIVKC--QKLTDDHVQFLIYQILRGL 138 V+ L+++ S +YLV DL ++ K T ++ ++ +L GL Sbjct: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD-------DEMTGYVATRWYRAP 191 YIH I+HRD+K +N+ + D LK+ DFGLAR + T V T WYR P Sbjct: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 E++L Y +D+W GCIMAE+ T + G QL LI +L G+ E+ + Sbjct: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD 257 Query: 252 SESARNYIQSLTQMPKMNFANVFIGA-NPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 + ++ + + + +P A+DL++K+LVLD +RI + AL H +F Sbjct: 258 NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF-- 315 Query: 311 YHDPDDEPVADPYDQSFES 329 + DP + S Sbjct: 316 WSDPMPSDLKGMLSTHLTS 334 >3HZT-A nrPDB Length = 467 Score = 288 bits (737), Expect = 3e-78, Method: Composition-based stats. Identities = 83/301 (27%), Positives = 141/301 (46%), Gaps = 43/301 (14%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP-FQSIIHAKRTYRELRLLKHM 78 + +RYQ + +GSGAYG V D TG A+K + + + ++ E+ +LK + Sbjct: 2 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 61 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTH-LMGADL-NNIVKCQKLTDDHVQFLIYQILR 136 H N++ L + F E+ + YLV G +L + I+ QK ++ ++ Q+L Sbjct: 62 DHPNIMKLYEFF------EDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLS 115 Query: 137 GLKYIHSADIIHRDLKPSNLAV---NEDCELKILDFGLARH--TDDEMTGYVATRWYRAP 191 G Y+H +I+HRDLKP NL + + D +KI+DFGL+ H +M + T +Y AP Sbjct: 116 GTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAP 175 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 E++ Y++ D+WS G I+ LL G F G + LK + + + ++ Sbjct: 176 EVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQV- 232 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311 + A L++ ML + KRI+A +AL H + ++ Sbjct: 233 --------------------------SDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKF 266 Query: 312 H 312 Sbjct: 267 C 267 >1G3N-A nrPDB Length = 326 Score = 286 bits (733), Expect = 8e-78, Method: Composition-based stats. Identities = 107/299 (35%), Positives = 159/299 (53%), Gaps = 15/299 (5%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTG-LRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK- 79 ++Y+ ++ +G GAYG V A D K G VA+K++ T RE+ +L+H++ Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 80 --HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC---QKLTDDHVQFLIYQI 134 H NV+ L DV T +R+ E + LV + DL + + + ++ +++Q+ Sbjct: 71 FEHPNVVRLFDVCTVSRTDRE-TKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 135 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM--TGYVATRWYRAPE 192 LRGL ++HS ++HRDLKP N+ V ++K+ DFGLAR +M T V T WYRAPE Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 ++L Y VD+WSVGCI AE+ + LF G+ +DQL IL ++G PG E + Sbjct: 190 VLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR-DV 247 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311 R S + P F + L DLL K L + KRI+A AL+H YF Sbjct: 248 ALPRQAFHSKSAQPIEKF---VTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 >4RGJ-A nrPDB Length = 520 Score = 283 bits (724), Expect = 8e-77, Method: Composition-based stats. Identities = 96/330 (29%), Positives = 156/330 (47%), Gaps = 47/330 (14%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP-FQ 60 S+ RP + Q N E+Y+ + +G G++G V + D TG A+K +S+ + Sbjct: 43 SKLRPGMFIQNSNVV---FNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVK 99 Query: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVK 118 + RE+ LLK + H N++ L + F E+ N YLV+ + G + I+ Sbjct: 100 RKTDKESLLREVELLKMLDHINIMKLYEFF------EDNNYYYLVSDVYTGGELFDEIIS 153 Query: 119 CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV----NEDCELKILDFGLARH 174 ++ + +I QIL G+ Y+H +++HRDLKP N+ + ED +KI+DFGL+ H Sbjct: 154 RKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTH 213 Query: 175 TD--DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQL 232 + +M + T +Y AP+++ Y++ DIWS G I+ LL+G F G++ D L Sbjct: 214 FEYSKKMKDKIGTAYYIAPDVLHG--TYDEKCDIWSCGVILYILLSGCPPFNGSNEYDIL 271 Query: 233 KLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLD 292 K + A Y L Q K + A DL++KML+ Sbjct: 272 KKV------------------EAGKYTFDLPQFKK---------ISDKAKDLIKKMLMYT 304 Query: 293 SDKRITAAQALAHAYFAQYHDPDDEPVADP 322 S RI+A AL H + D+ + P Sbjct: 305 SAVRISARDALEHEWIKMMTSKDNLNIDIP 334 >4MVF-A nrPDB Length = 506 Score = 282 bits (721), Expect = 2e-76, Method: Composition-based stats. Identities = 80/301 (26%), Positives = 136/301 (45%), Gaps = 44/301 (14%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 + ++Y +G G YG V D T A+K+ + I+ R ++E+ ++K + Sbjct: 55 LEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNIN--RFFQEIEIMKKLD 112 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGA--DLNNIVKCQKLTDDHVQFLIYQILRG 137 H N++ L + + E N +YL+ L ++I++ T+ + ++ QI Sbjct: 113 HPNIVKLYETY------ENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSA 166 Query: 138 LKYIHSADIIHRDLKPSNLAV---NEDCELKILDFGLARHTD--DEMTGYVATRWYRAPE 192 + Y+HS +I+HRDLKP N N+D LKI+DFGL+++ + T T +Y AP+ Sbjct: 167 IFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQ 226 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 ++ Y++ DIWS G IM LL G F G E+LKK+ Sbjct: 227 VLDG--KYDKKCDIWSSGVIMYTLLCGYPPFYGDTD---------------NEVLKKVKK 269 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYH 312 Y N + + A +L+ K+L + ++R T +AL H + Q Sbjct: 270 GEFCFY------------ENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHPWITQMT 317 Query: 313 D 313 Sbjct: 318 K 318 >2V7O-A nrPDB Length = 336 Score = 281 bits (718), Expect = 5e-76, Method: Composition-based stats. Identities = 89/315 (28%), Positives = 131/315 (41%), Gaps = 43/315 (13%) Query: 4 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII 63 Y Q + + YQ +G GA+ V A K ++ S Sbjct: 14 GTENLYFQSMATCT-RFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSAR 72 Query: 64 HAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQK 121 ++ RE R+ + +KH N++ L D S+ E YLV L+ G +IV + Sbjct: 73 DHQKLEREARICRLLKHPNIVRLHD------SISEEGFHYLVFDLVTGGELFEDIVAREY 126 Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE---LKILDFGLARHTDDE 178 ++ I+QIL + +IH DI+HRDLKP NL + C+ +K+ DFGLA E Sbjct: 127 YSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGE 186 Query: 179 MT---GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLI 235 G+ T Y +PE++ Y + VDIW+ G I+ LL G F D + I Sbjct: 187 QQAWFGFAGTPGYLSPEVLRKD-PYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI 245 Query: 236 LRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDK 295 A Y P + V P A +L+ +ML ++ K Sbjct: 246 ------------------KAGAY-----DFPSPEWDTV----TPEAKNLINQMLTINPAK 278 Query: 296 RITAAQALAHAYFAQ 310 RITA QAL H + Q Sbjct: 279 RITADQALKHPWVCQ 293 >5AIR-A nrPDB Length = 430 Score = 278 bits (712), Expect = 2e-75, Method: Composition-based stats. Identities = 93/315 (29%), Positives = 163/315 (51%), Gaps = 23/315 (7%) Query: 15 KTIWEVPER-----YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTY 69 T + P+R Y + +G+G++G V A +G VA+KK+ + + Sbjct: 52 ATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV------LQDKRFKN 105 Query: 70 RELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-----QKLTD 124 REL++++ + H N++ L F + ++ + LV + + + + Q L Sbjct: 106 RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPV 165 Query: 125 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC-ELKILDFGLARHT--DDEMTG 181 +V+ +YQ+ R L YIHS I HRD+KP NL ++ D LK+ DFG A+ + Sbjct: 166 IYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS 225 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGT 241 Y+ +R+YRAPE++ Y ++D+WS GC++AELL G+ +FPG +DQL I++++GT Sbjct: 226 YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGT 285 Query: 242 PGAELLKKISSESARNYIQSLTQMPKMNFANVF-IGANPLAVDLLEKMLVLDSDKRITAA 300 P E +++++ Q+ + VF P A+ L ++L R+T Sbjct: 286 PTREQIREMNPNYTE---FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPL 342 Query: 301 QALAHAYFAQYHDPD 315 +A AH++F + DP+ Sbjct: 343 EACAHSFFDELRDPN 357 >2VN9-A nrPDB Length = 301 Score = 278 bits (712), Expect = 2e-75, Method: Composition-based stats. Identities = 85/299 (28%), Positives = 128/299 (42%), Gaps = 42/299 (14%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 + + YQ +G GA+ V TG A K ++ S ++ RE R+ + +K Sbjct: 2 MTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLK 61 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRG 137 H N++ L D S+ E YLV L+ G +IV + ++ I QIL Sbjct: 62 HPNIVRLHD------SISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILES 115 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCE---LKILDFGLARHTDDEMT---GYVATRWYRAP 191 + + H I+HRDLKP NL + + +K+ DFGLA + G+ T Y +P Sbjct: 116 VNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSP 175 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 E++ Y + VD+W+ G I+ LL G F D + I Sbjct: 176 EVLRKD-PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQI---------------- 218 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 A Y P + V P A DL+ KML ++ KRITA++AL H + Q Sbjct: 219 --KAGAY-----DFPSPEWDTV----TPEAKDLINKMLTINPAKRITASEALKHPWICQ 266 >5G6V-A nrPDB Length = 324 Score = 277 bits (710), Expect = 4e-75, Method: Composition-based stats. Identities = 101/298 (33%), Positives = 147/298 (49%), Gaps = 15/298 (5%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E Y L +G G Y +V T VA+K++ + RE+ LLK +KH Sbjct: 2 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPC-TAIREVSLLKDLKHA 60 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIYQILRGLK 139 N++ L D+ +SL LV + DL + + +V+ ++Q+LRGL Sbjct: 61 NIVTLHDIIHTEKSLT------LVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLA 114 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEIMLN 196 Y H ++HRDLKP NL +NE ELK+ DFGLAR Y V T WYR P+I+L Sbjct: 115 YCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLG 174 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI-SSESA 255 Y+ +D+W VGCI E+ TGR LFPG+ +QL I R++GTP E I S+E Sbjct: 175 STDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEF 234 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHD 313 + Y + + + + DLL K+L + RI+A A+ H +F + Sbjct: 235 KTY--NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGE 290 >5FG8-A nrPDB Length = 285 Score = 277 bits (710), Expect = 4e-75, Method: Composition-based stats. Identities = 82/299 (27%), Positives = 128/299 (42%), Gaps = 42/299 (14%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 + Y +G GA+ V TG A K ++ + ++ RE R+ + + Sbjct: 12 FSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLH 71 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRG 137 H N++ L D S++E N YLV L+ G +IV + ++ I QIL Sbjct: 72 HPNIVRLHD------SIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILES 125 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCE---LKILDFGLARHTDDEMT---GYVATRWYRAP 191 + + H ++HRDLKP NL + + +K+ DFGLA + G+ T Y +P Sbjct: 126 VNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSP 185 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 E++ Y ++VDIW+ G I+ LL G F D I Sbjct: 186 EVL-KKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQI---------------- 228 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 A Y P + V P A +L+ +ML ++ +KRITAA+AL H + Q Sbjct: 229 --KAGAY-----DYPSPEWDTV----TPEAKNLINQMLTVNPNKRITAAEALKHPWICQ 276 >2VZ6-A nrPDB Length = 313 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 85/315 (26%), Positives = 129/315 (40%), Gaps = 52/315 (16%) Query: 4 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII 63 Y Q + YQ +G GA+ V G A K ++ S Sbjct: 14 GTENLYFQSM----------YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSAR 63 Query: 64 HAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQK 121 ++ RE R+ + +KH N++ L D S+ E YL+ L+ G +IV + Sbjct: 64 DHQKLEREARICRLLKHPNIVRLHD------SISEEGHHYLIFDLVTGGELFEDIVAREY 117 Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE---LKILDFGLARHTDDE 178 ++ I QIL + + H ++HRDLKP NL + + +K+ DFGLA + E Sbjct: 118 YSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGE 177 Query: 179 MT---GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLI 235 G+ T Y +PE++ Y + VD+W+ G I+ LL G F D + I Sbjct: 178 QQAWFGFAGTPGYLSPEVLRKD-PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI 236 Query: 236 LRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDK 295 A Y P + V P A DL+ KML ++ K Sbjct: 237 ------------------KAGAY-----DFPSPEWDTV----TPEAKDLINKMLTINPSK 269 Query: 296 RITAAQALAHAYFAQ 310 RITAA+AL H + + Sbjct: 270 RITAAEALKHPWISH 284 >4E7W-A nrPDB Length = 394 Score = 274 bits (702), Expect = 4e-74, Method: Composition-based stats. Identities = 104/356 (29%), Positives = 175/356 (49%), Gaps = 35/356 (9%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 Y N +G+G++G V A ++ VA+KK+ + + REL++++ +KH NV Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKV------LQDKRFKNRELQIMRIVKHPNV 94 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-----QKLTDDHVQFLIYQILRGL 138 + L F ++ + LV + + + Q + ++ +YQ+LR L Sbjct: 95 VDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSL 154 Query: 139 KYIHSADIIHRDLKPSNLAVNE-DCELKILDFGLARHT--DDEMTGYVATRWYRAPEIML 195 YIHS I HRD+KP NL ++ LK++DFG A+ + Y+ +R+YRAPE++ Sbjct: 155 AYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIF 214 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 +Y +DIWS GC+MAEL+ G+ LFPG IDQL I++++GTP E +K ++ Sbjct: 215 GATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYM 274 Query: 256 RNYIQSLTQMPKMNFANVF-IGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY--- 311 + Q+ F+ VF P A+DL+ ++L R+TA +AL H +F + Sbjct: 275 EH---KFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDELRTG 331 Query: 312 --HDPDDEPVADPYDQSFESRDLLIDEWKSLTYD-----------EVISFVPPPLD 354 P+ + ++ + E + D L +V +F P PL+ Sbjct: 332 EARMPNGRELPPLFNWTKEELSVRPDLISRLVPQHAEAELLSRGIDVHNFQPIPLE 387 >5U6Y-A nrPDB Length = 461 Score = 274 bits (701), Expect = 4e-74, Method: Composition-based stats. Identities = 83/295 (28%), Positives = 126/295 (42%), Gaps = 42/295 (14%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 YQ +G GA+ V G A K ++ S ++ RE R+ + +KH N+ Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 + L D S+ E YL+ L+ G +IV + ++ I QIL + + Sbjct: 62 VRLHD------SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 115 Query: 142 HSADIIHRDLKPSNLAVNEDCE---LKILDFGLARHTDDEMT---GYVATRWYRAPEIML 195 H ++HRDLKP NL + + +K+ DFGLA + E G+ T Y +PE++ Sbjct: 116 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR 175 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 Y + VD+W+ G I+ LL G F D + I A Sbjct: 176 KD-PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI------------------KA 216 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 Y P + V P A DL+ KML ++ KRITAA+AL H + + Sbjct: 217 GAY-----DFPSPEWDTV----TPEAKDLINKMLTINPSKRITAAEALKHPWISH 262 >2W96-B nrPDB Length = 306 Score = 274 bits (701), Expect = 5e-74, Method: Composition-based stats. Identities = 102/296 (34%), Positives = 148/296 (50%), Gaps = 14/296 (4%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK--- 79 RY+ ++ +G GAYG+V A D +G VA+K + P T RE+ LL+ ++ Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFE 64 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC---QKLTDDHVQFLIYQILR 136 H NV+ L+DV +R+ E V LV + DL + L + ++ L+ Q LR Sbjct: 65 HPNVVRLMDVCATSRTDREI-KVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLR 123 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT--GYVATRWYRAPEIM 194 GL ++H+ I+HRDLKP N+ V +K+ DFGLAR +M V T WYRAPE++ Sbjct: 124 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEVL 183 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 L Y VD+WSVGCI AE+ + LF G DQL I L+G P + + S Sbjct: 184 LQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP 242 Query: 255 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 + +V LL +ML + KRI+A +AL H+Y + Sbjct: 243 RGAF----PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 294 >2BDW-A nrPDB Length = 362 Score = 273 bits (699), Expect = 6e-74, Method: Composition-based stats. Identities = 84/297 (28%), Positives = 127/297 (42%), Gaps = 41/297 (13%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 + Y +G GA+ V TGL A K ++ S ++ RE R+ + ++ Sbjct: 27 FSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQ 86 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRG 137 H N++ L D S++E + YLV L+ G +IV + ++ I QIL Sbjct: 87 HPNIVRLHD------SIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILES 140 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCE---LKILDFGLARHTDDEM--TGYVATRWYRAPE 192 + Y HS I+HR+LKP NL + + +K+ DFGLA +D G+ T Y +PE Sbjct: 141 IAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPE 200 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 ++ Y++ VDIW+ G I+ LL G F D I Sbjct: 201 VL-KKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI----------------- 242 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 A Y P + V P A L++ ML ++ KRITA QAL + Sbjct: 243 -KAGAY-----DYPSPEWDTV----TPEAKSLIDSMLTVNPKKRITADQALKVPWIC 289 >3Q5I-A nrPDB Length = 504 Score = 273 bits (698), Expect = 8e-74, Method: Composition-based stats. Identities = 89/336 (26%), Positives = 137/336 (40%), Gaps = 61/336 (18%) Query: 2 SQERPTFYRQELNKTIW--------EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVK 53 S R Y Q + ++ E Y + +GSGAYG V + A+K Sbjct: 8 SSGRENLYFQGIAINPGMYVRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIK 67 Query: 54 KLSRPFQSIIH-----------AKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDV 102 + + + Y E+ LLK + H N+I L DVF E+ Sbjct: 68 VIKKSQFDKGRYSDDNKNIEKFHEEIYNEISLLKSLDHPNIIKLFDVF------EDKKYF 121 Query: 103 YLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE 160 YLVT G I+ K + ++ QIL G+ Y+H +I+HRD+KP N+ + Sbjct: 122 YLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLEN 181 Query: 161 DC---ELKILDFGLARHT--DDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAE 215 +KI+DFGL+ D ++ + T +Y APE++ YN+ D+WS G IM Sbjct: 182 KNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYYIAPEVL--KKKYNEKCDVWSCGVIMYI 239 Query: 216 LLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFI 275 LL G F G + D +K + + K I Sbjct: 240 LLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNI------------------------- 274 Query: 276 GANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311 + A +L++ ML D +KR TA +AL + +Y Sbjct: 275 --SDEAKELIKLMLTYDYNKRCTAEEALNSRWIKKY 308 >3BHH-A nrPDB Length = 295 Score = 272 bits (696), Expect = 2e-73, Method: Composition-based stats. Identities = 84/299 (28%), Positives = 128/299 (42%), Gaps = 42/299 (14%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 + + YQ +G GA+ V TG A K ++ S ++ RE R+ + +K Sbjct: 2 MTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLK 61 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRG 137 H N++ L D S+ E YLV L+ G +IV + ++ I QIL Sbjct: 62 HSNIVRLHD------SISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEA 115 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCE---LKILDFGLARHTDDEMT---GYVATRWYRAP 191 + + H ++HRDLKP NL + C+ +K+ DFGLA + G+ T Y +P Sbjct: 116 VLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSP 175 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 E++ Y + VDIW+ G I+ LL G F D + I Sbjct: 176 EVL-RKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI---------------- 218 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 A Y P + V P A +L+ +ML ++ KRITA +AL H + Q Sbjct: 219 --KAGAY-----DFPSPEWDTV----TPEAKNLINQMLTINPAKRITAHEALKHPWVCQ 266 >4BGQ-A nrPDB Length = 304 Score = 271 bits (694), Expect = 3e-73, Method: Composition-based stats. Identities = 97/302 (32%), Positives = 158/302 (52%), Gaps = 14/302 (4%) Query: 15 KTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRL 74 I V +++ L VG GAYG V +T VA+KK ++ + T REL++ Sbjct: 5 PNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKM 64 Query: 75 LKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC--QKLTDDHVQFLIY 132 L+ +K EN++ L + F L YLV + ++ +++ + + V+ IY Sbjct: 65 LRTLKQENIVELKEAFRRRGKL------YLVFEYVEKNMLELLEEMPNGVPPEKVKSYIY 118 Query: 133 QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD----EMTGYVATRWY 188 Q+++ + + H DI+HRD+KP NL ++ + LK+ DFG AR+ + VATRWY Sbjct: 119 QLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWY 178 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 R+PE++L Y ++VD+WSVGCI+ EL G+ LFPG IDQL I +++G +E +K Sbjct: 179 RSPELLLG-APYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMK 237 Query: 249 KISSESARNYIQSLTQMPKMNFANVFIGA-NPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 S + ++ + ++G N + +DL++ +L LD R Q L H Sbjct: 238 LFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPT 297 Query: 308 FA 309 F Sbjct: 298 FQ 299 >3SOA-A nrPDB Length = 444 Score = 271 bits (692), Expect = 4e-73, Method: Composition-based stats. Identities = 82/299 (27%), Positives = 126/299 (42%), Gaps = 42/299 (14%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 E YQ +G GA+ V G A ++ S ++ RE R+ + +K Sbjct: 9 FTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLK 68 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRG 137 H N++ L D S+ E YL+ L+ G +IV + ++ I QIL Sbjct: 69 HPNIVRLHD------SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEA 122 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCE---LKILDFGLARHTDDEMT---GYVATRWYRAP 191 + + H ++HR+LKP NL + + +K+ DFGLA + E G+ T Y +P Sbjct: 123 VLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSP 182 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 E++ Y + VD+W+ G I+ LL G F D + I Sbjct: 183 EVLRKD-PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI---------------- 225 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 A Y P + V P A DL+ KML ++ KRITAA+AL H + + Sbjct: 226 --KAGAY-----DFPSPEWDTV----TPEAKDLINKMLTINPSKRITAAEALKHPWISH 273 >3GC0-A nrPDB Length = 329 Score = 270 bits (691), Expect = 5e-73, Method: Composition-based stats. Identities = 101/299 (33%), Positives = 152/299 (50%), Gaps = 18/299 (6%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 +RY+ ++ +G G YG V A DT T VA+K++ + RE+ LLK ++H Sbjct: 34 DRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHR 93 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQKLTDDHVQFLIYQILRGLKY 140 N+I L V + + ++L+ DL + K ++ ++ +YQ++ G+ + Sbjct: 94 NIIELKSV------IHHNHRLHLIFEYAENDLKKYMDKNPDVSMRVIKSFLYQLINGVNF 147 Query: 141 IHSADIIHRDLKPSNLAV-----NEDCELKILDFGLARHTD---DEMTGYVATRWYRAPE 192 HS +HRDLKP NL + +E LKI DFGLAR + T + T WYR PE Sbjct: 148 CHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPE 207 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 I+L HY+ +VDIWS+ CI AE+L LFPG IDQL I ++G P ++ Sbjct: 208 ILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVT- 266 Query: 253 ESARNYIQSLTQMPKMNFANVF-IGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 + ++ QS + V + +DLL ML +D KRI+A AL H YF+ Sbjct: 267 -ALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFSH 324 >3KK8-A nrPDB Length = 284 Score = 270 bits (691), Expect = 7e-73, Method: Composition-based stats. Identities = 84/297 (28%), Positives = 127/297 (42%), Gaps = 41/297 (13%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 + Y +G GA+ V TGL A K ++ S ++ RE R+ + ++ Sbjct: 4 FSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQ 63 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRG 137 H N++ L D S++E + YLV L+ G +IV + ++ I QIL Sbjct: 64 HPNIVRLHD------SIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILES 117 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCE---LKILDFGLARHTDDEM--TGYVATRWYRAPE 192 + Y HS I+HR+LKP NL + + +K+ DFGLA +D G+ T Y +PE Sbjct: 118 IAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPE 177 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 ++ Y++ VDIW+ G I+ LL G F D I Sbjct: 178 VL-KKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI----------------- 219 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 A Y P + V P A L++ ML ++ KRITA QAL + Sbjct: 220 -KAGAY-----DYPSPEWDTV----TPEAKSLIDSMLTVNPKKRITADQALKVPWIC 266 >5ES1-A nrPDB Length = 328 Score = 269 bits (689), Expect = 9e-73, Method: Composition-based stats. Identities = 70/317 (22%), Positives = 135/317 (42%), Gaps = 42/317 (13%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 Y+ L +G G + V A TG VA+K + + + ++ +RE+R++K + H N Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPN 75 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKY 140 ++ L +V ++L YLV G + +V ++ + + QI+ + Y Sbjct: 76 IVKLFEVIETEKTL------YLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHY 129 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVATRWYRAPEIMLNWM 198 H +I+HRDLK NL ++ + +KI DFG + ++ + + Y APE+ Sbjct: 130 CHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKK 189 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY 258 + VDIWS+G I+ L++G F G + + + +LR Sbjct: 190 YDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKY------------------ 231 Query: 259 IQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDE- 317 V + +L + LVL+ KR T Q + + ++ ++ Sbjct: 232 -------------RVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELK 278 Query: 318 PVADPYDQSFESRDLLI 334 P +P + +++ + + Sbjct: 279 PYTEPEEDFGDTKRIEV 295 >3ZDU-A nrPDB Length = 325 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 94/294 (31%), Positives = 144/294 (48%), Gaps = 12/294 (4%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E Y+ L VG G+YG+V TG VA+K + ++ K RE++ LK HE Sbjct: 3 EMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVN-KIAMREIKFLKQFHHE 61 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGAD-LNNIVK-CQKLTDDHVQFLIYQILRGLK 139 N++ L++VF + + LV + L+ + C L ++ ++QILR + Sbjct: 62 NLVNLIEVFRQKKKIH------LVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAID 115 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT---DDEMTGYVATRWYRAPEIMLN 196 Y+HS +IIHRD+KP N+ V++ K+ DFG AR D VATRWYRAPE++L Sbjct: 116 YLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLK 175 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 256 Y + VDIW++GC++ E+ TG P + +D L I+ VG L S Sbjct: 176 DTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIF 235 Query: 257 NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 + N + N L D++ L +D RI+++ L H YF + Sbjct: 236 AGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTR 289 >4YZB-A nrPDB Length = 491 Score = 269 bits (688), Expect = 1e-72, Method: Composition-based stats. Identities = 87/312 (27%), Positives = 141/312 (45%), Gaps = 46/312 (14%) Query: 6 PTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP-FQSIIH 64 P + Q +RY+ +G G++G V D TG AVK +S+ + Sbjct: 17 PGMFVQHSTAA---FSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTD 73 Query: 65 AKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKL 122 + +E+ LLK + H N++ L + F E+ YLVT + G + I+ ++ Sbjct: 74 KELLLKEVELLKKLDHPNIMKLYEFF------EDKGYFYLVTEVYTGGELFDEIISRKRF 127 Query: 123 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN---EDCELKILDFGLARHTDD-- 177 ++ +I Q+L G+ Y+H I+HRDLKP NL + +D ++I+DFGL+ H + Sbjct: 128 SEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTK 187 Query: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 +M + T +Y APE++ Y++ D+WS G I+ LL+G F G + D LK + + Sbjct: 188 KMKDKIGTAYYIAPEVLHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEK 245 Query: 238 LVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI 297 T KK+ + A DL+ KML RI Sbjct: 246 GKFTFDLPQWKKV---------------------------SEPAKDLIRKMLAYVPTMRI 278 Query: 298 TAAQALAHAYFA 309 +A AL H + Sbjct: 279 SARDALEHEWLK 290 >2QNJ-A nrPDB Length = 328 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 75/340 (22%), Positives = 142/340 (41%), Gaps = 54/340 (15%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 Y+ L +G G + V A TG VA+K + + + ++ +RE+R++K + H N Sbjct: 13 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPN 72 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKY 140 ++ L +V ++L YL+ G + +V ++ + + QI+ ++Y Sbjct: 73 IVKLFEVIETEKTL------YLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQY 126 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVATRWYRAPEIMLNWM 198 H I+HRDLK NL ++ D +KI DFG + ++ + + Y APE+ Sbjct: 127 CHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKK 186 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY 258 + VD+WS+G I+ L++G F G + + + +LR Sbjct: 187 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY------------------ 228 Query: 259 IQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDE- 317 + + +LL++ LVL+ KR T Q + + H+ D+ Sbjct: 229 -------------RIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELK 275 Query: 318 PVADPYDQSFE------------SRDLLIDEWKSLTYDEV 345 P +P + S++ + + + YDE+ Sbjct: 276 PFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEI 315 >5Y86-A nrPDB Length = 588 Score = 267 bits (684), Expect = 4e-72, Method: Composition-based stats. Identities = 97/321 (30%), Positives = 157/321 (48%), Gaps = 37/321 (11%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 RY+ L +G G++G V +D K VA+K + + ++ E+R+L+H+K ++ Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKR---FHRQAAEEIRILEHLKKQD 264 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL---TDDHVQFLIYQILRGLK 139 G ++V S N V + L+ DL ++K K + V+ IL+ L Sbjct: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 Query: 140 YIHSADIIHRDLKPSNLAVNEDCE--LKILDFGLARHTDDEMTGYVATRWYRAPEIMLNW 197 +H IIH DLKP N+ + K++DFG + ++ Y+ +R+YRAPEI+L Sbjct: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGS 384 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK-------I 250 Y+ +DIWS GCI+AELLTG+ LFPG D DQL ++ L+G P +LL++ I Sbjct: 385 R-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443 Query: 251 SSESARNYIQSLTQ--------------------MPKMNFANVFIGANP-LAVDLLEKML 289 +S+ Y TQ ++ G + L ++ L++ L Sbjct: 444 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL 503 Query: 290 VLDSDKRITAAQALAHAYFAQ 310 D R+T AQAL H + ++ Sbjct: 504 HWDPSARLTPAQALRHPWISK 524 >4NIF-A nrPDB Length = 333 Score = 267 bits (684), Expect = 4e-72, Method: Composition-based stats. Identities = 91/343 (26%), Positives = 152/343 (44%), Gaps = 54/343 (15%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLL-KHM 78 + Y +G G+Y T + AVK + + + E+ +L ++ Sbjct: 6 FSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE------EIEILLRYG 59 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILR 136 +H N+I L DV+ ++ VYLVT LM G L+ I++ + ++ F+++ I + Sbjct: 60 QHPNIITLKDVY------DDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGK 113 Query: 137 GLKYIHSADIIHRDLKPSNLA-VNEDCE---LKILDFGLARHTDDE---MTGYVATRWYR 189 ++Y+HS ++HRDLKPSN+ V+E L+I DFG A+ E + T + Sbjct: 114 TVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFV 173 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 APE++ Y++ DIWS+G ++ +L G T F D + IL +G+ Sbjct: 174 APEVL-KRQGYDEGCDIWSLGILLYTMLAGYTPFANG-PSDTPEEILTRIGS-------- 223 Query: 250 ISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 + N+ V + A DL+ KML +D +R+TA Q L H + Sbjct: 224 -----------GKFTLSGGNWNTV----SETAKDLVSKMLHVDPHQRLTAKQVLQHPWVT 268 Query: 310 QYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPP 352 Q D P + Q + L+ + TY + S P P Sbjct: 269 Q---KDKLPQSQLSHQDLQ----LVKGAMAATYSALNSSKPTP 304 >3MN3-A nrPDB Length = 271 Score = 267 bits (682), Expect = 7e-72, Method: Composition-based stats. Identities = 73/291 (25%), Positives = 133/291 (45%), Gaps = 41/291 (14%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK-RTYRELRLLKHMKHE 81 YQ + +G G++G V A+ T TG +VA+K +++ + + R RE+ L+ ++H Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHP 64 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQKLTDDHVQFLIYQILRGLKY 140 ++I L DV ++ +++ +V G +L + + + K+++ + QI+ ++Y Sbjct: 65 HIIKLYDV------IKSKDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEY 118 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWM 198 H I+HRDLKP NL ++E +KI DFGL+ D + + Y APE++ + Sbjct: 119 CHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKL 178 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY 258 + VD+WS G I+ +L R F K I V T L Sbjct: 179 YAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFL------------ 226 Query: 259 IQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 +P A L+++ML+++ RI+ + + +F Sbjct: 227 -------------------SPGAAGLIKRMLIVNPLNRISIHEIMQDDWFK 258 >5KZ7-A nrPDB Length = 346 Score = 266 bits (680), Expect = 1e-71, Method: Composition-based stats. Identities = 76/330 (23%), Positives = 139/330 (42%), Gaps = 42/330 (12%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 Y+ L +G G + V A TG VAVK + + + ++ +RE+R++K + H N Sbjct: 34 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN 93 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKY 140 ++ L +V ++L YLV G + +V ++ + + QI+ ++Y Sbjct: 94 IVKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 147 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVATRWYRAPEIMLNWM 198 H I+HRDLK NL ++ D +KI DFG + +++ + + Y APE+ Sbjct: 148 CHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKK 207 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY 258 + VD+WS+G I+ L++G F G + + + +LR Sbjct: 208 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY------------------ 249 Query: 259 IQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDE- 317 + + +LL+K L+L+ KR T Q + + H+ D+ Sbjct: 250 -------------RIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELK 296 Query: 318 PVADPYDQSFESRDLLIDEWKSLTYDEVIS 347 P +P + R + T +E+ Sbjct: 297 PYVEPLPDYKDPRRTELMVSMGYTREEIQD 326 >4JG6-A nrPDB Length = 355 Score = 265 bits (677), Expect = 2e-71, Method: Composition-based stats. Identities = 87/354 (24%), Positives = 156/354 (44%), Gaps = 53/354 (14%) Query: 11 QELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR 70 Q+L++ + + Y+ +G G+Y T + AVK + + + Sbjct: 24 QQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE------ 77 Query: 71 ELRLL-KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHV 127 E+ +L ++ +H N+I L DV+ ++ VY+VT LM G L+ I++ + ++ Sbjct: 78 EIEILLRYGQHPNIITLKDVY------DDGKYVYVVTELMKGGELLDKILRQKFFSEREA 131 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLA-VNEDCE---LKILDFGLARHTDDE---MT 180 +++ I + ++Y+H+ ++HRDLKPSN+ V+E ++I DFG A+ E + Sbjct: 132 SAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLM 191 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240 T + APE++ Y+ DIWS+G ++ +LTG T F D + IL +G Sbjct: 192 TPCYTANFVAPEVLE-RQGYDAACDIWSLGVLLYTMLTGYTPFANGPD-DTPEEILARIG 249 Query: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300 + L + + A DL+ KML +D +R+TAA Sbjct: 250 SGKFSLSGGYWN-----------------------SVSDTAKDLVSKMLHVDPHQRLTAA 286 Query: 301 QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLD 354 L H + + D P Y + + L+ + TY + P L+ Sbjct: 287 LVLRHPWIVHW---DQLPQ---YQLNRQDAPHLVKGAMAATYSALNRNQSPVLE 334 >5IG1-A nrPDB Length = 344 Score = 264 bits (675), Expect = 5e-71, Method: Composition-based stats. Identities = 76/319 (23%), Positives = 131/319 (41%), Gaps = 52/319 (16%) Query: 28 SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLL 87 S +G GA+ +V + +TG AVK ++ + RE+ + ++HE+++ + Sbjct: 23 SVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMR 82 Query: 88 DVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSAD 145 F + + YLV + G + IV + + ++QIL L++ HS + Sbjct: 83 RAF------RDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKN 136 Query: 146 IIHRDLKPSNLAV---NEDCELKILDFGLARHTDDEMT--GYVATRWYRAPEIMLNWMHY 200 IIHRDLKP NL + + + +KI DFGLA + T G+ T Y +PE++ + Y Sbjct: 137 IIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVI-RRVPY 195 Query: 201 NQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQ 260 + VD+W+ G I+ LL G F DH I + +++ Sbjct: 196 DTAVDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTT-------- 247 Query: 261 SLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVA 320 A +L++ ML + +R T + L H + A+ P Sbjct: 248 -------------------AAKELIKAMLEPNPKRRPTVQELLQHPWIARRDVPGSV--- 285 Query: 321 DPYDQSFESRDLLIDEWKS 339 R ++E K Sbjct: 286 --------HRQATLEELKK 296 >2JC6-A nrPDB Length = 334 Score = 264 bits (674), Expect = 6e-71, Method: Composition-based stats. Identities = 80/298 (26%), Positives = 131/298 (43%), Gaps = 42/298 (14%) Query: 19 EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 ++ + ++ +G+GA+ V A + TG AVK + + + E+ +L+ + Sbjct: 19 DIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESS-IENEIAVLRKI 77 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILR 136 KHEN++ L D++ E N +YLV L+ G + IV+ T+ LI Q+L Sbjct: 78 KHENIVALEDIY------ESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLD 131 Query: 137 GLKYIHSADIIHRDLKPSNLAV---NEDCELKILDFGLARHTD--DEMTGYVATRWYRAP 191 + Y+H I+HRDLKP NL +E+ ++ I DFGL++ D M+ T Y AP Sbjct: 132 AVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAP 191 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 E++ Y++ VD WS+G I LL G F + + IL+ + I Sbjct: 192 EVLAQ-KPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDI- 249 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 + A D + ++ D +KR T QA H + A Sbjct: 250 --------------------------SDSAKDFIRNLMEKDPNKRYTCEQAARHPWIA 281 >4FG9-A nrPDB Length = 320 Score = 262 bits (670), Expect = 1e-70, Method: Composition-based stats. Identities = 80/298 (26%), Positives = 132/298 (44%), Gaps = 42/298 (14%) Query: 19 EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 ++ + Y +G+GA+ V A D +T VA+K +++ E+ +L + Sbjct: 15 DIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKI 73 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILR 136 KH N++ L D++ E +YL+ L+ G + IV+ T+ LI+Q+L Sbjct: 74 KHPNIVALDDIY------ESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLD 127 Query: 137 GLKYIHSADIIHRDLKPSNLA---VNEDCELKILDFGLARHTDDE--MTGYVATRWYRAP 191 +KY+H I+HRDLKP NL ++ED ++ I DFGL++ D ++ T Y AP Sbjct: 128 AVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAP 187 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 E++ Y++ VD WS+G I LL G F + + IL+ + I Sbjct: 188 EVLAQ-KPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDI- 245 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 + A D + ++ D +KR T QAL H + A Sbjct: 246 --------------------------SDSAKDFIRHLMEKDPEKRFTCEQALQHPWIA 277 >2YCR-A nrPDB Length = 323 Score = 261 bits (668), Expect = 2e-70, Method: Composition-based stats. Identities = 96/341 (28%), Positives = 158/341 (46%), Gaps = 60/341 (17%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR------TYRELRLL 75 + Y +GSGA G V AF+ KT +VA+K +S+ +I A+ E+ +L Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQ 133 K + H +I + + F + D Y+V LM G + +V ++L + + YQ Sbjct: 70 KKLNHPCIIKIKNFF-------DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQ 122 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVN---EDCELKILDFGLARHTDDE--MTGYVATRWY 188 +L ++Y+H IIHRDLKP N+ ++ EDC +KI DFG ++ + M T Y Sbjct: 123 MLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTY 182 Query: 189 RAPEIML--NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 APE+++ YN+ VD WS+G I+ L+G F ++H Q+ Sbjct: 183 LAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF--SEHRTQVS------------- 227 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHA 306 LK + N+I V+ + A+DL++K+LV+D R T +AL H Sbjct: 228 LKDQITSGKYNFI-----------PEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHP 276 Query: 307 YFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVIS 347 + D + +DLL +E +S +V++ Sbjct: 277 WLQD------------EDMKRKFQDLLSEENESTAKPQVLA 305 >3H4J-B nrPDB Length = 336 Score = 261 bits (667), Expect = 4e-70, Method: Composition-based stats. Identities = 79/302 (26%), Positives = 131/302 (43%), Gaps = 45/302 (14%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK-RTYRELRLLKHMKHEN 82 Y +G G++G V A KT +VA+K +SR R RE+ LK ++H + Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQKLTDDHVQFLIYQILRGLKYI 141 +I L DV T D+ +V G +L + + + +++T+D + QI+ ++Y Sbjct: 71 IIKLYDVITTP------TDIVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYC 124 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWMH 199 H I+HRDLKP NL ++++ +KI DFGL+ D + + Y APE++ ++ Sbjct: 125 HRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLY 184 Query: 200 YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYI 259 VD+WS G ++ +L GR F + K + V L Sbjct: 185 AGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFL------------- 231 Query: 260 QSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA----QYHDPD 315 +P A L+ +M+V D +RIT + +F Y P Sbjct: 232 ------------------SPGAQSLIRRMIVADPMQRITIQEIRRDPWFNVNLPDYLRPM 273 Query: 316 DE 317 +E Sbjct: 274 EE 275 >5ZTN-A nrPDB Length = 429 Score = 260 bits (665), Expect = 6e-70, Method: Composition-based stats. Identities = 92/327 (28%), Positives = 157/327 (48%), Gaps = 41/327 (12%) Query: 19 EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 V RY+ L +G G++G V A+D K VA+K + + ++ E+R+L+H+ Sbjct: 94 HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKR---FHRQAAEEIRILEHL 150 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL---TDDHVQFLIYQIL 135 + ++ ++V + N + + L+ +L ++K K + V+ + IL Sbjct: 151 RKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSIL 210 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCE--LKILDFGLARHTDDEMTGYVATRWYRAPEI 193 + L +H IIH DLKP N+ + + +K++DFG + + + Y+ +R+YRAPE+ Sbjct: 211 QCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEV 270 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 +L Y +D+WS+GCI+AELLTG L PG D DQL ++ L+G P +LL S+ Sbjct: 271 ILGAR-YGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDA--SK 327 Query: 254 SARNYIQSLT-----------------------------QMPKMNFANVFIGAN-PLAVD 283 A+N++ S + N G + PL +D Sbjct: 328 RAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLD 387 Query: 284 LLEKMLVLDSDKRITAAQALAHAYFAQ 310 L++ L D R+T QAL H + + Sbjct: 388 FLKQCLEWDPAVRMTPGQALRHPWLRR 414 >4REW-A nrPDB Length = 540 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 86/324 (26%), Positives = 134/324 (41%), Gaps = 48/324 (14%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHE 81 Y +G G +G V TG +VAVK L+R +S+ + RE++ LK +H Sbjct: 7 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 66 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV-KCQKLTDDHVQFLIYQILRGLK 139 ++I L V + +D+++V + G +L + + K +L + + L QIL G+ Sbjct: 67 HIIKLYQVISTP------SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 120 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNW 197 Y H ++HRDLKP N+ ++ KI DFGL+ D + + Y APE++ Sbjct: 121 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 180 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 ++ VDIWS G I+ LL G F K I + L Sbjct: 181 LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYL----------- 229 Query: 258 YIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDE 317 NP + LL+ ML +D KR + H +F Q D Sbjct: 230 --------------------NPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ-----DL 264 Query: 318 PVAD-PYDQSFESRDLLIDEWKSL 340 P P D S+ S + + K + Sbjct: 265 PKYLFPEDPSYSSTMIDDEALKEV 288 >3IS5-A nrPDB Length = 285 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 88/320 (27%), Positives = 147/320 (45%), Gaps = 54/320 (16%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S R Y Q + + + +GSGA+G V + +GL +K +++ +S Sbjct: 8 SSGRENLYFQGT------IDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKD-RS 60 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTH-LMGADLNNIV--- 117 + ++ E+ +LK + H N+I + +VF E+++++Y+V G +L + Sbjct: 61 QVPMEQIEAEIEVLKSLDHPNIIKIFEVF------EDYHNMYIVMETCEGGELLERIVSA 114 Query: 118 --KCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV---NEDCELKILDFGLA 172 + + L++ +V L+ Q++ L Y HS ++H+DLKP N+ + +KI+DFGLA Sbjct: 115 QARGKALSEGYVAELMKQMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLA 174 Query: 173 R--HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHID 230 +D+ T T Y APE+ + DIWS G +M LLTG F GT + Sbjct: 175 ELFKSDEHSTNAAGTALYMAPEVFKRDV--TFKCDIWSAGVVMYFLLTGCLPFTGTSLEE 232 Query: 231 QLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLV 290 +Q + N+A P AVDLL++ML Sbjct: 233 ----------------------------VQQKATYKEPNYAVECRPLTPQAVDLLKQMLT 264 Query: 291 LDSDKRITAAQALAHAYFAQ 310 D ++R +AAQ L H +F Q Sbjct: 265 KDPERRPSAAQVLHHEWFKQ 284 >3COM-A nrPDB Length = 314 Score = 258 bits (660), Expect = 2e-69, Method: Composition-based stats. Identities = 69/310 (22%), Positives = 131/310 (42%), Gaps = 45/310 (14%) Query: 4 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII 63 R + + + + E + L +G G+YGSV A +TG VA+K++ Sbjct: 11 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVES---- 66 Query: 64 HAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNI--VKCQ 120 + +E+ +++ +V+ + D+++V G +++I ++ + Sbjct: 67 DLQEIIKEISIMQQCDSPHVVKYYGSYFK------NTDLWIVMEYCGAGSVSDIIRLRNK 120 Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM- 179 LT+D + ++ L+GL+Y+H IHRD+K N+ +N + K+ DFG+A D M Sbjct: 121 TLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMA 180 Query: 180 --TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 + T ++ APE++ + YN DIWS+G E+ G+ + I ++ I Sbjct: 181 KRNTVIGTPFWMAPEVIQ-EIGYNCVADIWSLGITAIEMAEGKPPYA---DIHPMRAIFM 236 Query: 238 LVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI 297 + P K + D +++ LV ++R Sbjct: 237 IPTNPPPTFRK-------------------------PELWSDNFTDFVKQCLVKSPEQRA 271 Query: 298 TAAQALAHAY 307 TA Q L H + Sbjct: 272 TATQLLQHPF 281 >5WAX-A nrPDB Length = 310 Score = 258 bits (660), Expect = 2e-69, Method: Composition-based stats. Identities = 73/336 (21%), Positives = 132/336 (39%), Gaps = 43/336 (12%) Query: 12 ELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRE 71 ++ I +RY+ + +GSG +G + G VAVK + R + + + RE Sbjct: 1 SMDMPIMHDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQ---RE 57 Query: 72 LRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQF 129 + + ++H N+I +V + +V G I + ++D +F Sbjct: 58 IINHRSLRHPNIIRFKEVILTP------THLAIVMEYASGGELFERICNAGRFSEDEARF 111 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC--ELKILDFGLARH--TDDEMTGYVAT 185 Q++ G+ Y HS + HRDLK N ++ LKI DFG ++ + V T Sbjct: 112 FFQQLISGVSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGT 171 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKL-ILRLVGTPGA 244 Y APE++L + + D+WS G + +L G F D + I R++G Sbjct: 172 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILG---- 227 Query: 245 ELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304 S +Y+ +P DL+ ++ V + RIT + Sbjct: 228 ------VQYSIPDYV----------------HISPECQDLISRIFVANPATRITIPEIRN 265 Query: 305 HAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSL 340 H +F + + P D + +E + + + Sbjct: 266 HPWFLK-NLPADLMDDSTMSKQYEEPEQPMQSMDEI 300 >5YKS-A nrPDB Length = 377 Score = 257 bits (658), Expect = 4e-69, Method: Composition-based stats. Identities = 73/329 (22%), Positives = 134/329 (40%), Gaps = 46/329 (13%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 Y +G G + V A TG +VAVK + + + ++E+R +K ++H N+ Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI 96 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV--KCQKLTDDHVQFLIYQILRGLKY 140 + L +V ++ +YL+ L G D+ + + + L +D + QI+ + Y Sbjct: 97 VRLYEV------IDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 150 Query: 141 IHSADIIHRDLKPSNL-AVNEDCELKILDFGLAR--HTDDEMTGYVATRWYRAPEIMLNW 197 H ++HRDLKP N+ + +K+ DFG + ++T + Y APEI+L Sbjct: 151 CHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGD 210 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 + VDIWS+G I+ L+ G+ F + + L +I+ T + + Sbjct: 211 EYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHV----------- 259 Query: 258 YIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDE 317 + DL+ +ML D +R + + H + D Sbjct: 260 --------------------SKECKDLITRMLQRDPKRRASLEEIENHPWLQGV---DPS 296 Query: 318 PVADPYDQSFESRDLLIDEWKSLTYDEVI 346 P ++L +E S+ V+ Sbjct: 297 PATKYNIPLVSYKNLSEEEHNSIIQRMVL 325 >3E3P-A nrPDB Length = 360 Score = 256 bits (655), Expect = 8e-69, Method: Composition-based stats. Identities = 94/310 (30%), Positives = 158/310 (50%), Gaps = 23/310 (7%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM--- 78 +R+Q G G +G+V + TG+ VA+KK+ I + REL++++ + Sbjct: 23 DRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKV------IQDPRFRNRELQIMQDLAVL 76 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYL--VTHLMGADLNN-----IVKCQKLTDDHVQFLI 131 H N++ L F + D+YL V + L+ + ++ + Sbjct: 77 HHPNIVQLQSYFYTLGE-RDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFL 135 Query: 132 YQILRGLKYIH--SADIIHRDLKPSNLAVNE-DCELKILDFGLARHTD--DEMTGYVATR 186 +Q++R + +H S ++ HRD+KP N+ VNE D LK+ DFG A+ + Y+ +R Sbjct: 136 FQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSR 195 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 +YRAPE++ HY VDIWSVGCI AE++ G +F G + QL I+R++G P E+ Sbjct: 196 YYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREV 255 Query: 247 LKKISSESARNYIQSLTQMPKMN-FANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAH 305 L+K++ + + +P N F++ + A DLL +L ++R+ +AL H Sbjct: 256 LRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEALCH 315 Query: 306 AYFAQYHDPD 315 YF + HDP Sbjct: 316 PYFDELHDPA 325 >4D2V-A nrPDB Length = 356 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 76/312 (24%), Positives = 134/312 (42%), Gaps = 45/312 (14%) Query: 19 EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 E+ + Y+ +G+G + V A TG VA+K + + R E+ LK++ Sbjct: 26 ELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS-DLPRIKTEIEALKNL 84 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILR 136 +H+++ L V LE N +++V G + I+ +L+++ + + QI+ Sbjct: 85 RHQHICQLYHV------LETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVS 138 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT----DDEMTGYVATRWYRAPE 192 + Y+HS HRDLKP NL +E +LK++DFGL D + Y APE Sbjct: 139 AVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPE 198 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 ++ + D+WS+G ++ L+ G F + I+R Sbjct: 199 LIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMR--------------- 243 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ-Y 311 +PK +P ++ LL++ML +D KRI+ L H + Q Y Sbjct: 244 --------GKYDVPKW--------LSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDY 287 Query: 312 HDPDDEPVADPY 323 + P + +P+ Sbjct: 288 NYPVEWQSKNPF 299 >3UTO-A nrPDB Length = 573 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 86/353 (24%), Positives = 147/353 (41%), Gaps = 49/353 (13%) Query: 6 PTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHA 65 +Y Q + V + Y +G+GA+G V + TG A K + P +S Sbjct: 141 KQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHES--DK 198 Query: 66 KRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV--KCQKL 122 + +E++ + ++H ++ L D F E+ N++ ++ M G +L V + K+ Sbjct: 199 ETVRKEIQTMSVLRHPTLVNLHDAF------EDDNEMVMIYEFMSGGELFEKVADEHNKM 252 Query: 123 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN--EDCELKILDFGLARHTDDEMT 180 ++D + Q+ +GL ++H + +H DLKP N+ ELK++DFGL H D + + Sbjct: 253 SEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQS 312 Query: 181 GYV--ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL 238 V T + APE+ D+WSVG + LL+G + F G + + L+ + Sbjct: 313 VKVTTGTAEFAAPEVAEG-KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSC 371 Query: 239 VGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT 298 + F G + D + K+L+ D + R+T Sbjct: 372 DWNMD---------------------------DSAFSGISEDGKDFIRKLLLADPNTRMT 404 Query: 299 AAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPP 351 QAL H + P + P D Q SR I + YD +PP Sbjct: 405 IHQALEHPWLT----PGNAPGRD--SQIPSSRYTKIRDSIKTKYDAWPEPLPP 451 >4CFF-A nrPDB Length = 571 Score = 254 bits (650), Expect = 4e-68, Method: Composition-based stats. Identities = 83/324 (25%), Positives = 132/324 (40%), Gaps = 48/324 (14%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHE 81 Y +G G +G V TG +VAVK L+R +S+ + RE++ LK +H Sbjct: 34 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 93 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV-KCQKLTDDHVQFLIYQILRGLK 139 ++I L V + D ++V + G +L + + K ++ + + L QIL + Sbjct: 94 HIIKLYQVISTP------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 147 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNW 197 Y H ++HRDLKP N+ ++ KI DFGL+ D + + Y APE++ Sbjct: 148 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 207 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 ++ VDIWS G I+ LL G F K I V L + +++ Sbjct: 208 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT----- 262 Query: 258 YIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDE 317 LL ML +D KR T H +F Q D Sbjct: 263 --------------------------LLMHMLQVDPLKRATIKDIREHEWFKQ-----DL 291 Query: 318 PVAD-PYDQSFESRDLLIDEWKSL 340 P P D S+++ + + K + Sbjct: 292 PSYLFPEDPSYDANVIDDEAVKEV 315 >2J90-A nrPDB Length = 304 Score = 254 bits (649), Expect = 4e-68, Method: Composition-based stats. Identities = 83/318 (26%), Positives = 137/318 (43%), Gaps = 52/318 (16%) Query: 4 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII 63 Y Q + V + Y+ +GSG + V TG A K + + S Sbjct: 14 GTENLYFQSM------VEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSS 67 Query: 64 HA----KRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV- 117 + RE+ +L+ ++H N+I L D+F E DV L+ L+ G +L + + Sbjct: 68 RRGVSREEIEREVNILREIRHPNIITLHDIF------ENKTDVVLILELVSGGELFDFLA 121 Query: 118 KCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE----DCELKILDFGLAR 173 + + LT+D + QIL G+ Y+HS I H DLKP N+ + + + +K++DFG+A Sbjct: 122 EKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAH 181 Query: 174 HT--DDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQ 231 +E T + APE ++N+ D+WS+G I LL+G + F G + Sbjct: 182 KIEAGNEFKNIFGTPEFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQET 240 Query: 232 LKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVL 291 L I + E F + LA D + ++LV Sbjct: 241 LTNISAVNYDFDEEY---------------------------FSNTSELAKDFIRRLLVK 273 Query: 292 DSDKRITAAQALAHAYFA 309 D +R+T AQ+L H++ Sbjct: 274 DPKRRMTIAQSLEHSWIK 291 >4CFH-A nrPDB Length = 493 Score = 254 bits (649), Expect = 5e-68, Method: Composition-based stats. Identities = 87/324 (26%), Positives = 134/324 (41%), Gaps = 48/324 (14%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHE 81 Y +G G +G V TG +VAVK L+R +S+ + RE++ LK +H Sbjct: 34 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 93 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV-KCQKLTDDHVQFLIYQILRGLK 139 ++I L V + +D+++V + G +L + + K +L + + L QIL G+ Sbjct: 94 HIIKLYQVISTP------SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 147 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNW 197 Y H ++HRDLKP N+ ++ KI DFGL+ D + + Y APE++ Sbjct: 148 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 207 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 ++ VDIWS G I+ LL G F K I + L Sbjct: 208 LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYL----------- 256 Query: 258 YIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDE 317 NP + LL+ ML +D KR T H +F Q D Sbjct: 257 --------------------NPSVISLLKHMLQVDPMKRATIKDIREHEWFKQ-----DL 291 Query: 318 PVAD-PYDQSFESRDLLIDEWKSL 340 P P D S+ S + + K + Sbjct: 292 PKYLFPEDPSYSSTMIDDEALKEV 315 >4RED-A nrPDB Length = 351 Score = 254 bits (649), Expect = 5e-68, Method: Composition-based stats. Identities = 85/324 (26%), Positives = 133/324 (41%), Gaps = 48/324 (14%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHE 81 Y +G G +G V TG VAVK L+R +S+ + RE++ LK +H Sbjct: 15 HYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 74 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV-KCQKLTDDHVQFLIYQILRGLK 139 ++I L V + +D+++V + G +L + + K +L + + L QIL G+ Sbjct: 75 HIIKLYQVISTP------SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 128 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNW 197 Y H ++HRDLKP N+ ++ KI DFGL+ D + + Y APE++ Sbjct: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 ++ VDIWS G I+ LL G F K I + L Sbjct: 189 LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYL----------- 237 Query: 258 YIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDE 317 NP + LL+ ML +D KR + H +F Q D Sbjct: 238 --------------------NPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ-----DL 272 Query: 318 PVAD-PYDQSFESRDLLIDEWKSL 340 P P D S+ + + + K + Sbjct: 273 PKYLFPEDPSYSTTMIDDEALKEV 296 >5JZN-A nrPDB Length = 280 Score = 254 bits (648), Expect = 7e-68, Method: Composition-based stats. Identities = 84/310 (27%), Positives = 138/310 (44%), Gaps = 43/310 (13%) Query: 11 QELNKTIWEVP----ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK 66 +E+++ +++P ERY+ +G G + V + T A+K + + Sbjct: 4 EEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEH- 62 Query: 67 RTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNN-IVKCQKLTD 124 E+ +L+ +KH N++ L++ ++ ++YLV L+ G DL + I K T+ Sbjct: 63 MIQNEVSILRRVKHPNIVLLIE------EMDVPTELYLVMELVKGGDLFDAITSTNKYTE 116 Query: 125 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV----NEDCELKILDFGLARHTDDEMT 180 ++Y + +KY+HS +I+HRD+KP NL V + LK+ DFGLA D + Sbjct: 117 RDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLY 176 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240 T Y APEI+ Y VDIW+ G I LL G F G+ G Sbjct: 177 TVCGTPTYVAPEIIA-ETGYGLKVDIWAAGVITYILLCGFPPFRGS-------------G 222 Query: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300 L +I + P + NV + A +L+ ML++D D+R +A Sbjct: 223 DDQEVLFDQI--------LMGQVDFPSPYWDNV----SDSAKELITMMLLVDVDQRFSAV 270 Query: 301 QALAHAYFAQ 310 Q L H + Sbjct: 271 QVLEHPWVND 280 >5EZV-A nrPDB Length = 560 Score = 253 bits (647), Expect = 8e-68, Method: Composition-based stats. Identities = 83/324 (25%), Positives = 132/324 (40%), Gaps = 48/324 (14%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHE 81 Y +G G +G V TG +VAVK L+R +S+ + RE++ LK +H Sbjct: 29 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 88 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV-KCQKLTDDHVQFLIYQILRGLK 139 ++I L V + D ++V + G +L + + K ++ + + L QIL + Sbjct: 89 HIIKLYQVISTP------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 142 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNW 197 Y H ++HRDLKP N+ ++ KI DFGL+ D + + Y APE++ Sbjct: 143 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 202 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 ++ VDIWS G I+ LL G F K I V L + +++ Sbjct: 203 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT----- 257 Query: 258 YIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDE 317 LL ML +D KR T H +F Q D Sbjct: 258 --------------------------LLMHMLQVDPLKRATIKDIREHEWFKQ-----DL 286 Query: 318 PVAD-PYDQSFESRDLLIDEWKSL 340 P P D S+++ + + K + Sbjct: 287 PSYLFPEDPSYDANVIDDEAVKEV 310 >3EB0-A nrPDB Length = 383 Score = 253 bits (647), Expect = 8e-68, Method: Composition-based stats. Identities = 96/334 (28%), Positives = 166/334 (49%), Gaps = 50/334 (14%) Query: 21 PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH 80 ++Y +G+G++G VC FD ++G R A+KK+ + + REL ++K + H Sbjct: 6 SKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKV------LQDPRYKNRELDIMKVLDH 59 Query: 81 ENVIGLLDVFT--------PARSLEEFNDVY------------------------LVTHL 108 N+I L+D F P + ++ N + ++ Sbjct: 60 VNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEY 119 Query: 109 MGADLNNIVKC-----QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDC 162 + L+ ++K + + + + IYQ+ R + +IHS I HRD+KP NL VN +D Sbjct: 120 VPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDN 179 Query: 163 ELKILDFGLARHT--DDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGR 220 LK+ DFG A+ + Y+ +R+YRAPE+ML Y ++D+WS+GC+ EL+ G+ Sbjct: 180 TLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGK 239 Query: 221 TLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANP- 279 LF G IDQL I++++GTP E + +++ + ++ + P Sbjct: 240 PLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEV---RFPTLKAKDWRKILPEGTPS 296 Query: 280 LAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHD 313 LA+DLLE++L + D RI +A+AH +F + Sbjct: 297 LAIDLLEQILRYEPDLRINPYEAMAHPFFDHLRN 330 >4CQG-A nrPDB Length = 331 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 78/311 (25%), Positives = 135/311 (43%), Gaps = 45/311 (14%) Query: 19 EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 E+ + Y+ +G+G + V A TG VA+K + + R E+ LK + Sbjct: 6 ELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGS-DLPRVKTEIDALKSL 64 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILR 136 +H+++ L V LE N +++V G + I+ +L+++ + + QIL Sbjct: 65 RHQHICQLYHV------LETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILS 118 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT----DDEMTGYVATRWYRAPE 192 + Y+HS HRDLKP NL +E+ +LK++DFGL D + + Y APE Sbjct: 119 AVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPE 178 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 ++ + D+WS+G ++ L+ G F + + K I+R Sbjct: 179 LIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMR--------------- 223 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ-Y 311 ++PK +P ++ LL++ML +D KRI+ L H + Q Y Sbjct: 224 --------GKYEVPKW--------LSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDY 267 Query: 312 HDPDDEPVADP 322 P + P Sbjct: 268 SCPVEWQSKTP 278 >6FD3-A nrPDB Length = 300 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 69/297 (23%), Positives = 132/297 (44%), Gaps = 39/297 (13%) Query: 16 TIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLL 75 ++ + ++Y +G GA G+V A D TG VA+K+++ Q + E+ ++ Sbjct: 16 SVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIINEILVM 73 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQIL 135 + K+ N++ LD + L ++ +L G L ++V + + + + + L Sbjct: 74 RENKNPNIVNYLDSYLVGDEL-----WVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECL 128 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVATRWYRAPE 192 + L ++HS +IHRD+K N+ + D +K+ DFG E + V T ++ APE Sbjct: 129 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 188 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 + + Y VDIWS+G + E++ G + + + L LI GTP + +++ Sbjct: 189 V-VTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIA-TNGTPELQNPERL-- 244 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 + + D L + L +D D+R +A + L H + Sbjct: 245 -------------------------SAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 276 >3D2K-A nrPDB Length = 272 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 71/292 (24%), Positives = 122/292 (41%), Gaps = 42/292 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR-ELRLLKHMKH 80 E + P+G G +G+V A + ++ +A+K L + + R E+ + H++H Sbjct: 12 EDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRH 71 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHL--MGADLNNIVKCQKLTDDHVQFLIYQILRGL 138 N++ L F + VYL+ +G + K + + I ++ L Sbjct: 72 PNILRLYGYF------HDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANAL 125 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH-TDDEMTGYVATRWYRAPEIMLNW 197 Y HS +IHRD+KP NL + + ELKI DFG + H T T Y PE++ Sbjct: 126 SYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR 185 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 MH ++ VD+WS+G + E L G F + + + I R+ T + Sbjct: 186 MH-DEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFV----------- 233 Query: 258 YIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 A DL+ ++L ++ +R+T A+ L H + Sbjct: 234 --------------------TEGARDLISRLLKHNASQRLTLAEVLEHPWIK 265 >2JAM-A nrPDB Length = 304 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 75/296 (25%), Positives = 123/296 (41%), Gaps = 42/296 (14%) Query: 19 EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 + + + + +GSGA+ V TG A+K + + E+ +LK + Sbjct: 6 NIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSP--AFRDSSLENEIAVLKKI 63 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILR 136 KHEN++ L D++ E YLV L+ G + I++ T+ +I Q+L Sbjct: 64 KHENIVTLEDIY------ESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLS 117 Query: 137 GLKYIHSADIIHRDLKPSNLAV---NEDCELKILDFGLARHTDDE-MTGYVATRWYRAPE 192 +KY+H I+HRDLKP NL E+ ++ I DFGL++ + M+ T Y APE Sbjct: 118 AVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPE 177 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 ++ Y++ VD WS+G I LL G F + I + I Sbjct: 178 VLAQ-KPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDI-- 234 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 + A D + +L D ++R T +AL+H + Sbjct: 235 -------------------------SESAKDFICHLLEKDPNERYTCEKALSHPWI 265 >1KOA-A nrPDB Length = 491 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 86/353 (24%), Positives = 147/353 (41%), Gaps = 49/353 (13%) Query: 6 PTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHA 65 +Y Q + V + Y +G+GA+G V + TG A K + P +S Sbjct: 35 KQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHES--DK 92 Query: 66 KRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV--KCQKL 122 + +E++ + ++H ++ L D F E+ N++ ++ M G +L V + K+ Sbjct: 93 ETVRKEIQTMSVLRHPTLVNLHDAF------EDDNEMVMIYEFMSGGELFEKVADEHNKM 146 Query: 123 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN--EDCELKILDFGLARHTDDEMT 180 ++D + Q+ +GL ++H + +H DLKP N+ ELK++DFGL H D + + Sbjct: 147 SEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQS 206 Query: 181 GYV--ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL 238 V T + APE+ D+WSVG + LL+G + F G + + L+ + Sbjct: 207 VKVTTGTAEFAAPEVAEG-KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSC 265 Query: 239 VGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT 298 + F G + D + K+L+ D + R+T Sbjct: 266 DWNMD---------------------------DSAFSGISEDGKDFIRKLLLADPNTRMT 298 Query: 299 AAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPP 351 QAL H + P + P D Q SR I + YD +PP Sbjct: 299 IHQALEHPWLT----PGNAPGRD--SQIPSSRYTKIRDSIKTKYDAWPEPLPP 345 >3I6U-A nrPDB Length = 419 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 93/330 (28%), Positives = 152/330 (46%), Gaps = 60/330 (18%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR------TYRELRLL 75 + Y +GSGA G V AF+ KT +VA++ +S+ +I A+ E+ +L Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQ 133 K + H +I + + F + D Y+V LM G + +V ++L + + YQ Sbjct: 195 KKLNHPCIIKIKNFF-------DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQ 247 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVN---EDCELKILDFGLARHTDDE--MTGYVATRWY 188 +L ++Y+H IIHRDLKP N+ ++ EDC +KI DFG ++ + M T Y Sbjct: 248 MLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTY 307 Query: 189 RAPEIML--NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 APE+++ YN+ VD WS+G I+ L+G F ++H Q+ Sbjct: 308 LAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF--SEHRTQVS------------- 352 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHA 306 LK + N+I V+ + A+DL++K+LV+D R T +AL H Sbjct: 353 LKDQITSGKYNFI-----------PEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHP 401 Query: 307 YFAQYHDPDDEPVADPYDQSFESRDLLIDE 336 + D + +DLL +E Sbjct: 402 WLQD------------EDMKRKFQDLLSEE 419 >4LG4-A nrPDB Length = 299 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 66/294 (22%), Positives = 125/294 (42%), Gaps = 45/294 (15%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E + L +G G+YGSV A ++G VA+K++ + +E+ +++ Sbjct: 11 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES----DLQEIIKEISIMQQCDSP 66 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNI--VKCQKLTDDHVQFLIYQILRGL 138 V+ + D+++V G +++I ++ + L +D + ++ L+GL Sbjct: 67 YVVKYYGSYFK------NTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGL 120 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM---TGYVATRWYRAPEIML 195 +Y+H IHR++K N+ +N + K+ DFG+A D M + T ++ APE++ Sbjct: 121 EYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 180 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 + YN DIWS+G E+ G+ + I ++ I + P K Sbjct: 181 -EIGYNCVADIWSLGITSIEMAEGKPPYA---DIHPMRAIFMIPTNPPPTFRK------- 229 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 + D ++K LV + ++R TA Q L H + Sbjct: 230 ------------------PELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK 265 >3ZUT-A nrPDB Length = 362 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 73/350 (20%), Positives = 141/350 (40%), Gaps = 49/350 (14%) Query: 12 ELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRE 71 ++ I +RY+ + +GSG +G D ++ VAVK + R + + K RE Sbjct: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK---RE 65 Query: 72 LRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQF 129 + + ++H N++ +V + +V G I + ++D +F Sbjct: 66 IINHRSLRHPNIVRFKEVILTP------THLAIVMEYASGGELFERICNAGRFSEDEARF 119 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC--ELKILDFGLARH--TDDEMTGYVAT 185 Q++ G+ Y H+ + HRDLK N ++ LKI FG ++ + V T Sbjct: 120 FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGT 179 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 Y APE++L + + D+WS G + +L G F Sbjct: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFED-------------------- 219 Query: 246 LLKKISSESARNYIQSLTQMPKMNFA-NVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304 E +N+ +++ ++ + +A ++ +P L+ ++ V D KRI+ + Sbjct: 220 ------PEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 Query: 305 HAYFAQYHDPDDEPVADPYDQSFESRDLL---IDEWKSLTYDEVISFVPP 351 H +F + + P D + F+ D I+E + + + PP Sbjct: 274 HEWFLK-NLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEATV---PP 319 >3F3Z-A nrPDB Length = 277 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 78/304 (25%), Positives = 130/304 (42%), Gaps = 44/304 (14%) Query: 14 NKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELR 73 T ++ + Y + +G G++G V A T +R A KK+ + F + R +E+ Sbjct: 1 GSTKGDINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYF--VEDVDRFKQEIE 58 Query: 74 LLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLI 131 ++K + H N+I L + F E+ D+YLV L G +V + + ++ Sbjct: 59 IMKSLDHPNIIRLYETF------EDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIM 112 Query: 132 YQILRGLKYIHSADIIHRDLKPSNLAV---NEDCELKILDFGLARHT--DDEMTGYVATR 186 +L + Y H ++ HRDLKP N + D LK++DFGLA M V T Sbjct: 113 KDVLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTP 172 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 +Y +P+++ Y D WS G +M LL G F + + I Sbjct: 173 YYVSPQVLEGL--YGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIR---------- 220 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHA 306 + P+ ++ NV +P A L+ ++L +RIT+ QAL H Sbjct: 221 -------------EGTFTFPEKDWLNV----SPQAESLIRRLLTKSPKQRITSLQALEHE 263 Query: 307 YFAQ 310 +F + Sbjct: 264 WFEK 267 >6C9D-A nrPDB Length = 459 Score = 251 bits (641), Expect = 3e-67, Method: Composition-based stats. Identities = 75/358 (20%), Positives = 142/358 (39%), Gaps = 60/358 (16%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 Y+ +G G + V A TG VAVK + + + ++ +RE+R++K + H N Sbjct: 22 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 81 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKY 140 ++ L +V ++L YLV G + +V ++ + + QI+ ++Y Sbjct: 82 IVKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 135 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVATRWYRAPEIMLNWM 198 H I+HRDLK NL ++ D +KI DFG + +++ + + Y APE+ Sbjct: 136 CHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKK 195 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY 258 + VD+WS+G I+ L++G F G + + + +LR Y Sbjct: 196 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR-------------GKYRIPFY 242 Query: 259 IQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDE- 317 + + + + KR + Q + + H+ ++ Sbjct: 243 MSTDCENLLKKLLVLN------------------PIKRGSLEQIMKDRWMNVGHEEEELK 284 Query: 318 PVADPYDQSFESRDLLI------------DEWKSLTYDEVISF------VPPPLDQEE 357 P +P +++ + I D + YDEV++ PP + E Sbjct: 285 PYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEVMATYILLGRKPPEFEGGE 342 >4UZD-A nrPDB Length = 287 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 71/292 (24%), Positives = 119/292 (40%), Gaps = 42/292 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR-ELRLLKHMKH 80 E ++ P+G G +G+V A + ++ +A+K L + + R E+ + H++H Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRH 67 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHL--MGADLNNIVKCQKLTDDHVQFLIYQILRGL 138 N++ L F + VYL+ +G + K K + I ++ L Sbjct: 68 PNILRLYGYF------HDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANAL 121 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH-TDDEMTGYVATRWYRAPEIMLNW 197 Y HS +IHRD+KP NL + ELKI DFG + H T T Y PE++ Sbjct: 122 SYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR 181 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 MH ++ VD+WS+G + E L G+ F + + K I R+ T + Sbjct: 182 MH-DEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFV----------- 229 Query: 258 YIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 A DL+ ++L + +R + L H + Sbjct: 230 --------------------TEGARDLISRLLKHNPSQRPMLREVLEHPWIT 261 >3UC3-A nrPDB Length = 361 Score = 250 bits (639), Expect = 6e-67, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 125/305 (40%), Gaps = 40/305 (13%) Query: 12 ELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRE 71 L+ I +RY + +GSG +G D T VAVK + R + RE Sbjct: 10 PLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG---AAIDENVQRE 66 Query: 72 LRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNN-IVKCQKLTDDHVQFL 130 + + ++H N++ +V L ++ + G +L I + ++D +F Sbjct: 67 IINHRSLRHPNIVRFKEVILTPTHL-----AIIMEYASGGELYERICNAGRFSEDEARFF 121 Query: 131 IYQILRGLKYIHSADIIHRDLKPSNLAVNEDC--ELKILDFGLARH--TDDEMTGYVATR 186 Q+L G+ Y HS I HRDLK N ++ LKI DFG ++ + V T Sbjct: 122 FQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP 181 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 Y APE++L + + D+WS G + +L G F Sbjct: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFED--------------------- 220 Query: 247 LKKISSESARNYIQSLTQMPKMNFA-NVFIGANPLAVDLLEKMLVLDSDKRITAAQALAH 305 E R+Y +++ ++ + ++ I +P L+ ++ V D RI+ + H Sbjct: 221 -----PEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTH 275 Query: 306 AYFAQ 310 ++F + Sbjct: 276 SWFLK 280 >2Y7J-A nrPDB Length = 365 Score = 250 bits (639), Expect = 7e-67, Method: Composition-based stats. Identities = 77/332 (23%), Positives = 142/332 (42%), Gaps = 57/332 (17%) Query: 3 QERPTFYRQELNKTI----W----EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKK 54 + Y Q + W E ++Y +G G V TG AVK Sbjct: 67 KGTENLYFQSMGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKI 126 Query: 55 LS------RPFQSIIHAKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTH 107 + P Q + T RE +L+ + H ++I L+D + E + ++LV Sbjct: 127 MEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSY------ESSSFMFLVFD 180 Query: 108 LM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELK 165 LM G + + + L++ + ++ +L + ++H+ +I+HRDLKP N+ ++++ +++ Sbjct: 181 LMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIR 240 Query: 166 ILDFGLARHT--DDEMTGYVATRWYRAPEIMLNWM-----HYNQTVDIWSVGCIMAELLT 218 + DFG + H +++ T Y APEI+ M Y + VD+W+ G I+ LL Sbjct: 241 LSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLA 300 Query: 219 GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGAN 278 G F I L++I+ + Q + + + Sbjct: 301 GSPPFWHRRQILMLRMIM-----------------------EGQYQFSSPEWDDR----S 333 Query: 279 PLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 DL+ ++L +D + R+TA QAL H +F + Sbjct: 334 STVKDLISRLLQVDPEARLTAEQALQHPFFER 365 >4CZT-A nrPDB Length = 464 Score = 250 bits (639), Expect = 7e-67, Method: Composition-based stats. Identities = 77/333 (23%), Positives = 135/333 (40%), Gaps = 53/333 (15%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSIIHAKRTYRELRLLKHMKHE 81 +Y+ +G G + V A + + G VA+K + + + RE+ +K +KH Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 71 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLK 139 NVI + +V +Y V + G + I +L +D + Q++ + Sbjct: 72 NVIRMFEVMASK------TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 125 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEMTGYVATRWYRAPEIM 194 Y HS + HRDLKP NL ++ + LK+ DFGL+ D + T Y APE++ Sbjct: 126 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 185 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 N + D+WS G I+ L+ G F ++ K I + T Sbjct: 186 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF-------- 237 Query: 255 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ-YHD 313 + A L++++L + RIT A+ + + +F + Y Sbjct: 238 -----------------------SASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 274 Query: 314 PDDEP-------VADPYDQSFESRDLLIDEWKS 339 P E V +D S ES++L+++ + Sbjct: 275 PKFENADVSLDDVDAIFDDSGESKNLVVERREE 307 >2HAK-A nrPDB Length = 328 Score = 250 bits (638), Expect = 9e-67, Method: Composition-based stats. Identities = 69/330 (20%), Positives = 133/330 (40%), Gaps = 42/330 (12%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 Y+ +G G + V A TG VAVK + + + ++ +RE+R++K + H N Sbjct: 16 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 75 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKY 140 ++ L +V ++L YLV G + +V ++ + + QI+ ++Y Sbjct: 76 IVKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 129 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVATRWYRAPEIMLNWM 198 H I+HRDLK NL ++ D +KI DFG + +++ + + Y APE+ Sbjct: 130 CHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKK 189 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY 258 + VD+WS+G I+ L++G F G + + + +LR Y Sbjct: 190 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR-------------GKYRIPFY 236 Query: 259 IQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDE- 317 + + + + KR + Q + + H+ ++ Sbjct: 237 MSTDCENLLKKLLVLN------------------PIKRGSLEQIMKDRWMNVGHEEEELK 278 Query: 318 PVADPYDQSFESRDLLIDEWKSLTYDEVIS 347 P +P +++ + I DE+ Sbjct: 279 PYTEPDPDFNDTKRIDIMVTMGFARDEIND 308 >5XZW-A nrPDB Length = 471 Score = 250 bits (638), Expect = 9e-67, Method: Composition-based stats. Identities = 86/306 (28%), Positives = 136/306 (44%), Gaps = 53/306 (17%) Query: 22 ERYQNL-SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH 80 + + + VG GA+ +V A + TG AVK +S+ + I + REL +L+ + H Sbjct: 195 KDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKR-KVIGNMDGVTRELEVLQKLNH 253 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK-LTDDHVQFLIYQILRGL 138 ++ L + E+ Y+V + G DL + V + +D + + QIL + Sbjct: 254 PRIVRLKGFY------EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAI 307 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCE--LKILDFGLARHTDDE--MTGYVATRWYRAPEIM 194 KYIHS I HRDLKP N+ + +D +KI DFGLA+ + M + T Y APE++ Sbjct: 308 KYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVI 367 Query: 195 LN------------WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 242 Y+ VD+WS+GC++ +LTG F G+ K I R G+ Sbjct: 368 RGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGR--GSY 425 Query: 243 GAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQA 302 LK + A D ++ +L +D + R TAA+A Sbjct: 426 HEGPLKDFR-------------------------ISEEARDFIDSLLQVDPNNRSTAAKA 460 Query: 303 LAHAYF 308 L H + Sbjct: 461 LNHPWI 466 >6AO5-A nrPDB Length = 362 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 66/294 (22%), Positives = 125/294 (42%), Gaps = 45/294 (15%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E + L +G G+YGSV A ++G VA+K++ + +E+ +++ Sbjct: 10 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES----DLQEIIKEISIMQQCDSP 65 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNI--VKCQKLTDDHVQFLIYQILRGL 138 V+ + D+++V G +++I ++ + L +D + ++ L+GL Sbjct: 66 YVVKYYGSYFK------NTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGL 119 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM---TGYVATRWYRAPEIML 195 +Y+H IHR++K N+ +N + K+ DFG+A D M + T ++ APE++ Sbjct: 120 EYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 179 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 + YN DIWS+G E+ G+ + I ++ I + P K Sbjct: 180 -EIGYNCVADIWSLGITSIEMAEGKPPYA---DIHPMRAIFMIPTNPPPTFRK------- 228 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 + D ++K LV + ++R TA Q L H + Sbjct: 229 ------------------PELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK 264 >3UDB-A nrPDB Length = 317 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 71/345 (20%), Positives = 139/345 (40%), Gaps = 46/345 (13%) Query: 12 ELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRE 71 ++ I +RY+ + +G+G +G D + VAVK + R + + K RE Sbjct: 9 PMDLPIMHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVK---RE 65 Query: 72 LRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQF 129 + + ++H N++ +V + +V G I + ++D +F Sbjct: 66 IINHRSLRHPNIVRFKEVILTP------THLAIVMEYASGGELFERICNAGRFSEDEARF 119 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC--ELKILDFGLARH--TDDEMTGYVAT 185 Q++ G+ Y H+ + HRDLK N ++ LKI DFG ++ + V T Sbjct: 120 FFQQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGT 179 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 Y APE++L + + D+WS G + +L G F Sbjct: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFED-------------------- 219 Query: 246 LLKKISSESARNYIQSLTQMPKMNFA-NVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304 E +N+ +++ ++ + +A ++ +P L+ ++ V D KRI+ + Sbjct: 220 ------PEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 Query: 305 HAYFAQYHDPDDEPVADPYDQSFESRDLL---IDEWKSLTYDEVI 346 H +F + + P D + F+ D I+E + + + Sbjct: 274 HEWFLK-NLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEATV 317 >3GUB-A nrPDB Length = 295 Score = 247 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 86/315 (27%), Positives = 137/315 (43%), Gaps = 52/315 (16%) Query: 7 TFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHA- 65 T +RQE V + Y +GSG + V + TGL+ A K + + Sbjct: 2 TVFRQE------NVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRG 55 Query: 66 ---KRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV-KCQ 120 + RE+ +LK ++H NVI L +V+ E DV L+ L+ G +L + + + + Sbjct: 56 VSREDIEREVSILKEIQHPNVITLHEVY------ENKTDVILIGELVAGGELFDFLAEKE 109 Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC----ELKILDFGLARHTD 176 LT++ + QIL G+ Y+HS I H DLKP N+ + + +KI+DFGLA D Sbjct: 110 SLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKID 169 Query: 177 --DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKL 234 +E T + APE ++N+ D+WS+G I LL+G + F G + L Sbjct: 170 FGNEFKNIFGTPEFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLAN 228 Query: 235 ILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSD 294 + + E F + LA D + ++LV D Sbjct: 229 VSAVNYEFEDEY---------------------------FSNTSALAKDFIRRLLVKDPK 261 Query: 295 KRITAAQALAHAYFA 309 KR+T +L H + Sbjct: 262 KRMTIQDSLQHPWIK 276 >2YAB-A nrPDB Length = 361 Score = 247 bits (631), Expect = 6e-66, Method: Composition-based stats. Identities = 81/302 (26%), Positives = 132/302 (43%), Gaps = 46/302 (15%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHA----KRTYRELRLL 75 V + Y +GSG + V + TGL A K + + + RE+ +L Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSIL 69 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV-KCQKLTDDHVQFLIYQ 133 + + H N+I L DV+ E DV L+ L+ G +L + + + + L+++ I Q Sbjct: 70 RQVLHPNIITLHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQ 123 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDC----ELKILDFGLARHTDD--EMTGYVATRW 187 IL G+ Y+H+ I H DLKP N+ + + +K++DFGLA +D E T Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247 + APE ++N+ D+WS+G I LL+G + F G + L I + E Sbjct: 184 FVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEF- 241 Query: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 F + LA D + K+LV ++ KR+T +AL H + Sbjct: 242 --------------------------FSQTSELAKDFIRKLLVKETRKRLTIQEALRHPW 275 Query: 308 FA 309 Sbjct: 276 IT 277 >5J5T-A nrPDB Length = 370 Score = 247 bits (630), Expect = 7e-66, Method: Composition-based stats. Identities = 80/370 (21%), Positives = 148/370 (40%), Gaps = 70/370 (18%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E ++ + +GSG YG V A + TG A+K + +E+ ++K KH Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGE--DFAVVQQEIIMMKDCKHP 61 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK-CQKLTDDHVQFLIYQILRGLK 139 N++ + + +++ G L +I L++ + ++ + L+GL Sbjct: 62 NIVAYFGSYLR------RDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLY 115 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD---DEMTGYVATRWYRAPEI--M 194 Y+HS +HRD+K +N+ + ++ +K+ DFG++ + ++ T ++ APE+ + Sbjct: 116 YLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAV 175 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 YNQ D+W+VG EL + + L L+ + P K S S Sbjct: 176 ERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNS 235 Query: 255 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKM-LVLDSDKRITAAQALAHAYFAQ--- 310 +++ KM L + KR TA + L H + Q Sbjct: 236 FHHFV---------------------------KMALTKNPKKRPTAEKLLQHPFVTQHLT 268 Query: 311 ---------------------YHDPDDEP-VADPYDQSFESRDLLIDEWK-SLTYDEVIS 347 + D D EP VA P+ SR++ ++ + +T+ +V Sbjct: 269 RSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQV-K 327 Query: 348 FVPPPLDQEE 357 F PP + E Sbjct: 328 FDPPLRKETE 337 >3TAC-A nrPDB Length = 361 Score = 247 bits (630), Expect = 8e-66, Method: Composition-based stats. Identities = 76/306 (24%), Positives = 129/306 (42%), Gaps = 50/306 (16%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSI---IHAKRTYRELRLLK 76 + Y+ +G G + V + +TG + AVK + + + + RE + Sbjct: 24 FEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICH 83 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADL-NNIVKCQK----LTDDHVQFL 130 +KH +++ LL+ ++ L Y+V M GADL IVK ++ Sbjct: 84 MLKHPHIVELLETYSSDGML------YMVFEFMDGADLCFEIVKRADAGFVYSEAVASHY 137 Query: 131 IYQILRGLKYIHSADIIHRDLKPSNLAVNE---DCELKILDFGLARHTDDE---MTGYVA 184 + QIL L+Y H +IIHRD+KP + + +K+ FG+A + G V Sbjct: 138 MRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVG 197 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGA 244 T + APE+ + Y + VD+W G I+ LL+G F GT Sbjct: 198 TPHFMAPEV-VKREPYGKPVDVWGCGVILFILLSGCLPFYGTKER--------------- 241 Query: 245 ELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304 I+ +M ++++ + A DL+ +ML+LD +RIT +AL Sbjct: 242 ---------LFEGIIKGKYKMNPRQWSHI----SESAKDLVRRMLMLDPAERITVYEALN 288 Query: 305 HAYFAQ 310 H + + Sbjct: 289 HPWLKE 294 >2F57-A nrPDB Length = 317 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 75/330 (22%), Positives = 141/330 (42%), Gaps = 55/330 (16%) Query: 4 ERPTFYRQELNKTIWE-------------VPERYQ-NLSPVGSGAYGSVCAAFDTKTGLR 49 R Y Q +++ E P Y N +G G+ G VC A + TG + Sbjct: 13 GRENLYFQSMSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQ 72 Query: 50 VAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM 109 VAVKK+ + + + E+ +++ H+NV+ + + +++++V + Sbjct: 73 VAVKKM--DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVG------DELWVVMEFL 124 Query: 110 -GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILD 168 G L +IV ++ ++ + + +LR L Y+H+ +IHRD+K ++ + D +K+ D Sbjct: 125 EGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSD 184 Query: 169 FGLARHTDDE---MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPG 225 FG E V T ++ APE++ + + Y VDIWS+G ++ E++ G + Sbjct: 185 FGFCAQVSKEVPKRKSLVGTPYWMAPEVI-SRLPYGTEVDIWSLGIMVIEMIDGEPPYFN 243 Query: 226 TDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLL 285 + ++ I + P + L K+SS + L Sbjct: 244 EPPLQAMRRIRDSL-PPRVKDLHKVSS---------------------------VLRGFL 275 Query: 286 EKMLVLDSDKRITAAQALAHAYFAQYHDPD 315 + MLV + +R TA + L H + P Sbjct: 276 DLMLVREPSQRATAQELLGHPFLKLAGPPS 305 >2YZA-A nrPDB Length = 276 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 77/293 (26%), Positives = 120/293 (40%), Gaps = 42/293 (14%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHE 81 Y +G G +G V TG +VAVK L+R +S+ + RE++ LK +H Sbjct: 12 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 71 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV-KCQKLTDDHVQFLIYQILRGLK 139 ++I L V + D ++V + G +L + + K ++ + + L QIL + Sbjct: 72 HIIKLYQVISTP------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 125 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNW 197 Y H ++HRDLKP N+ ++ KI DFGL+ D + + Y APE++ Sbjct: 126 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGR 185 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 ++ VDIWS G I+ LL G F K I V L + +++ Sbjct: 186 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT----- 240 Query: 258 YIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 LL ML +D KR T H +F Q Sbjct: 241 --------------------------LLMHMLQVDPLKRATIKDIREHEWFKQ 267 >2HW6-A nrPDB Length = 307 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 76/317 (23%), Positives = 137/317 (43%), Gaps = 41/317 (12%) Query: 14 NKTIWEVPERYQNL-SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYREL 72 + + + Y+ +G GAY V A + G AVK + + Q+ R +RE+ Sbjct: 4 DSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEK--QAGHSRSRVFREV 61 Query: 73 RLLKHMK-HENVIGLLDVFTPARSLEEFNDVYLVTH-LMGAD-LNNIVKCQKLTDDHVQF 129 L + ++N++ L++ F E+ YLV L G L +I K + + Sbjct: 62 ETLYQCQGNKNILELIEFF------EDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASR 115 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNED---CELKILDFGLARHT----------D 176 ++ + L ++H+ I HRDLKP N+ +KI DF L Sbjct: 116 VVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITT 175 Query: 177 DEMTGYVATRWYRAPEIML----NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQL 232 E+T + Y APE++ Y++ D+WS+G ++ +L+G F G D Sbjct: 176 PELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD-- 233 Query: 233 KLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLD 292 G E+ + ++ + + + P ++A++ + A DL+ K+LV D Sbjct: 234 ------CGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHI----SSEAKDLISKLLVRD 283 Query: 293 SDKRITAAQALAHAYFA 309 + +R++AAQ L H + Sbjct: 284 AKQRLSAAQVLQHPWVQ 300 >4B6L-A nrPDB Length = 281 Score = 245 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 80/306 (26%), Positives = 128/306 (41%), Gaps = 44/306 (14%) Query: 21 PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKL-SRPFQSIIHAKRTYRELRLLKHMK 79 Y +G G + A DT+TG AVK + ++ E+ L + ++ Sbjct: 8 GRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQ 67 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQK-LTDDHVQFLIYQILRG 137 H +++ + E+ +++Y+ L L +I K + L + V++ + QIL G Sbjct: 68 HRHIVRF------SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSG 121 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD---EMTGYVATRWYRAPEIM 194 LKY+H I+HRDLK N + E+ ELK+ DFGLA + T Y APE++ Sbjct: 122 LKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVL 181 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 L H D+WS+GC+M LL G F D + + I ++ T A L Sbjct: 182 LRQGH-GPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASL-------- 232 Query: 255 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 314 + A LL +L R + Q L H +F + + P Sbjct: 233 -----------------------SLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTP 269 Query: 315 DDEPVA 320 D P++ Sbjct: 270 DRLPIS 275 >2W4O-A nrPDB Length = 349 Score = 245 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 85/311 (27%), Positives = 127/311 (40%), Gaps = 46/311 (14%) Query: 6 PTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHA 65 P ++ N+ + + ++ S +G GA V T A+K L + + Sbjct: 39 PDYWIDGSNRDA--LSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKT----VDK 92 Query: 66 KRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLT 123 K E+ +L + H N+I L ++F E ++ LV L+ G + IV+ + Sbjct: 93 KIVRTEIGVLLRLSHPNIIKLKEIF------ETPTEISLVLELVTGGELFDRIVEKGYYS 146 Query: 124 DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV---NEDCELKILDFGLARHTDDE-- 178 + + QIL + Y+H I+HRDLKP NL D LKI DFGL++ + + Sbjct: 147 ERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVL 206 Query: 179 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL 238 M T Y APEI+ Y VD+WSVG I LL G F DQ Sbjct: 207 MKTVCGTPGYCAPEILRGC-AYGPEVDMWSVGIITYILLCGFEPFYDERG-DQF------ 258 Query: 239 VGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT 298 R + + V + A DL+ K++VLD KR+T Sbjct: 259 ---------------MFRRILNCEYYFISPWWDEVSLN----AKDLVRKLIVLDPKKRLT 299 Query: 299 AAQALAHAYFA 309 QAL H + Sbjct: 300 TFQALQHPWVT 310 >3HKO-A nrPDB Length = 345 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 91/368 (24%), Positives = 148/368 (40%), Gaps = 90/368 (24%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S R Y Q ++ E+ ++Y +G G+YG V A + +T A+K +++ Sbjct: 8 SSGRENLYFQG--GSLLELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIR 65 Query: 62 IIHAK---RTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADL---- 113 I+ K R E+RL+K + H N+ L +V+ E+ + LV L G L Sbjct: 66 QINPKDVERIKTEVRLMKKLHHPNIARLYEVY------EDEQYICLVMELCHGGHLLDKL 119 Query: 114 ------------NNIVKCQKLT-------------------------DDHVQFLIYQILR 136 ++VK Q + + ++ QI Sbjct: 120 NVFIDDSTGKCAMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFS 179 Query: 137 GLKYIHSADIIHRDLKPSNLAV--NEDCELKILDFGLARHTDD-------EMTGYVATRW 187 L Y+H+ I HRD+KP N N+ E+K++DFGL++ MT T + Sbjct: 180 ALHYLHNQGICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPY 239 Query: 188 YRAPEIM-LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 + APE++ Y D WS G ++ LL G FPG + D + +L Sbjct: 240 FVAPEVLNTTNESYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLN--------- 290 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHA 306 KK+ E+ + +PLA DLL +L + D+R A +AL H Sbjct: 291 -KKLCFENPN-----------------YNVLSPLARDLLSNLLNRNVDERFDAMRALQHP 332 Query: 307 YFAQYHDP 314 + +Q+ D Sbjct: 333 WISQFSDK 340 >1PHK-A nrPDB Length = 298 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 77/309 (24%), Positives = 126/309 (40%), Gaps = 50/309 (16%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRT-------YREL 72 E Y+ +G G V T AVK + A+ +E+ Sbjct: 15 FYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEV 74 Query: 73 RLLKHMK-HENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQF 129 +L+ + H N+I L D + E +LV LM G + + + L++ + Sbjct: 75 DILRKVSGHPNIIQLKDTY------ETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRK 128 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD--DEMTGYVATRW 187 ++ +L + +H +I+HRDLKP N+ +++D +K+ DFG + D +++ T Sbjct: 129 IMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPS 188 Query: 188 YRAPEIML-----NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 242 Y APEI+ N Y + VD+WS G IM LL G F + L++I+ Sbjct: 189 YLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQF 248 Query: 243 GAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQA 302 G+ + DL+ + LV+ KR TA +A Sbjct: 249 GSPEWDDY---------------------------SDTVKDLVSRFLVVQPQKRYTAEEA 281 Query: 303 LAHAYFAQY 311 LAH +F QY Sbjct: 282 LAHPFFQQY 290 >3DAK-A nrPDB Length = 290 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 74/313 (23%), Positives = 131/313 (41%), Gaps = 47/313 (15%) Query: 17 IWEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLL 75 W + + Y+ +GSGA V AA+ +VA+K+++ + +E++ + Sbjct: 4 PWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLE-KCQTSMDELLKEIQAM 62 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKC---------QKLTDD 125 H N++ F ++++LV L+ G + +I+K L + Sbjct: 63 SQCHHPNIVSYYTSFVVK------DELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDES 116 Query: 126 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT--------DD 177 + ++ ++L GL+Y+H IHRD+K N+ + ED ++I DFG++ + Sbjct: 117 TIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNK 176 Query: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 +V T + APE+M Y+ DIWS G EL TG + + L +L Sbjct: 177 VRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVL--MLT 234 Query: 238 LVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI 297 L P + E + Y +S +M + L D +KR Sbjct: 235 LQNDPPSLETGVQDKEMLKKYGKSFRKM-------------------ISLCLQKDPEKRP 275 Query: 298 TAAQALAHAYFAQ 310 TAA+ L H +F + Sbjct: 276 TAAELLRHKFFQK 288 >1FOT-A nrPDB Length = 318 Score = 244 bits (624), Expect = 4e-65, Method: Composition-based stats. Identities = 70/316 (22%), Positives = 134/316 (42%), Gaps = 46/316 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP-FQSIIHAKRTYRELRLLKHMKH 80 + +Q L +G+G++G V G A+K L + + + T E +L + H Sbjct: 6 QDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTH 65 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQKLTDDHVQFLIYQILRGLK 139 +I + F A+ + ++ ++ G +L +++ K Q+ + +F ++ L+ Sbjct: 66 PFIIRMWGTFQDAQQI-----FMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALE 120 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMH 199 Y+HS DII+RDLKP N+ ++++ +KI DFG A++ D T Y APE+ ++ Sbjct: 121 YLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEV-VSTKP 179 Query: 200 YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYI 259 YN+++D WS G ++ E+L G T F ++ + + IL Sbjct: 180 YNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFF------------- 226 Query: 260 QSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQALAHAYFAQ--YH 312 N DLL +++ D +R+ H +F + + Sbjct: 227 ------------------NEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWE 268 Query: 313 DPDDEPVADPYDQSFE 328 + PY+ + Sbjct: 269 KLLSRNIETPYEPPIQ 284 >4KS7-A nrPDB Length = 292 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 71/290 (24%), Positives = 129/290 (44%), Gaps = 39/290 (13%) Query: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 +G G+ G VC A + +G +VAVK + + + + E+ +++ +H NV+ + Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMM--DLRKQQRRELLFNEVVIMRDYQHFNVVEMYK 87 Query: 89 VFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIH 148 + L L+ L G L +IV +L ++ + + +L+ L Y+H+ +IH Sbjct: 88 SYLVGEEL-----WVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIH 142 Query: 149 RDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVATRWYRAPEIMLNWMHYNQTVD 205 RD+K ++ + D +K+ DFG + V T ++ APE++ + Y VD Sbjct: 143 RDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL-YATEVD 201 Query: 206 IWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQM 265 IWS+G ++ E++ G + + +K RL +P +L Sbjct: 202 IWSLGIMVIEMVDGEPPYFSDSPVQAMK---RLRDSPPPKLKNSH--------------- 243 Query: 266 PKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPD 315 +P+ D LE+MLV D +R TA + L H + Q P+ Sbjct: 244 ----------KVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPE 283 >5D7A-A nrPDB Length = 308 Score = 244 bits (622), Expect = 6e-65, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 119/299 (39%), Gaps = 44/299 (14%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM-KHEN 82 ++ + VG+G YG V KTG A+K + + +E+ +LK H N Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD---EEEEIKQEINMLKKYSHHRN 75 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMGA----DLNNIVKCQKLTDDHVQFLIYQILRGL 138 + F + ++LV GA DL K L ++ + ++ +ILRGL Sbjct: 76 IATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGL 135 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD---DEMTGYVATRWYRAPEIML 195 ++H +IHRD+K N+ + E+ E+K++DFG++ D ++ T ++ APE++ Sbjct: 136 SHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 195 Query: 196 NWMH----YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 + Y+ D+WS+G E+ G + L LI R Sbjct: 196 CDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPR-------------- 241 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 ++ ++ F +E LV + +R Q + H + Sbjct: 242 --------NPAPRLKSKKWSKKFQS-------FIESCLVKNHSQRPATEQLMKHPFIRD 285 >4JXF-A nrPDB Length = 266 Score = 244 bits (622), Expect = 7e-65, Method: Composition-based stats. Identities = 73/302 (24%), Positives = 132/302 (43%), Gaps = 45/302 (14%) Query: 16 TIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKL-SRPFQSIIHAKRTYRELRL 74 I E E ++ + +G G++ V A TGL VA+K + + +R E+++ Sbjct: 1 CIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKI 60 Query: 75 LKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ--KLTDDHVQFLI 131 +KH +++ L + F E+ N VYLV + ++N +K + +++ + + Sbjct: 61 HCQLKHPSILELYNYF------EDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFM 114 Query: 132 YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA---RHTDDEMTGYVATRWY 188 +QI+ G+ Y+HS I+HRDL SNL + + +KI DFGLA + ++ T Y Sbjct: 115 HQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNY 174 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 +PEI H D+WS+GC+ LL GR F + L ++ + L Sbjct: 175 ISPEIATRSAH-GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFL-- 231 Query: 249 KISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 + A DL+ ++L + R++ + L H + Sbjct: 232 -----------------------------SIEAKDLIHQLLRRNPADRLSLSSVLDHPFM 262 Query: 309 AQ 310 ++ Sbjct: 263 SR 264 >2A27-A nrPDB Length = 321 Score = 243 bits (621), Expect = 9e-65, Method: Composition-based stats. Identities = 82/302 (27%), Positives = 134/302 (44%), Gaps = 46/302 (15%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP----FQSIIHAKRTYRELRLL 75 V + Y +GSG + V + TGL A K + + + + + RE+ +L Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSIL 69 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV-KCQKLTDDHVQFLIYQ 133 + + H NVI L DV+ E DV L+ L+ G +L + + + + L+++ I Q Sbjct: 70 RQVLHHNVITLHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQ 123 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDC----ELKILDFGLARHTDD--EMTGYVATRW 187 IL G+ Y+H+ I H DLKP N+ + + +K++DFGLA +D E T Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247 + APE ++N+ D+WS+G I LL+G + F G + L I + E Sbjct: 184 FVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEF- 241 Query: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 F + LA D + K+LV ++ KR+T +AL H + Sbjct: 242 --------------------------FSQTSELAKDFIRKLLVKETRKRLTIQEALRHPW 275 Query: 308 FA 309 Sbjct: 276 IT 277 >4D28-A nrPDB Length = 446 Score = 243 bits (620), Expect = 9e-65, Method: Composition-based stats. Identities = 67/298 (22%), Positives = 122/298 (40%), Gaps = 43/298 (14%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHE 81 +Y+ +G G + V A +T TG VA+K +++ + RE+ ++K ++H Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLK 139 N++ L +V L + +Y+V + G + IV +L +D + Q++ + Sbjct: 70 NIVRLYEV------LASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVA 123 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVATRWYRAPEIMLN 196 + HS + HRDLKP NL ++ + LK+ DFGL+ + + T Y APE++ Sbjct: 124 HCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSG 183 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 256 + DIWS G I+ +L G F TD + I +A Sbjct: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI------------------NAA 225 Query: 257 NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 314 + + + L+ ++L + RI +F + + P Sbjct: 226 EF-------------DCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRKNYVP 270 >4FIE-A nrPDB Length = 423 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 71/300 (23%), Positives = 137/300 (45%), Gaps = 42/300 (14%) Query: 21 PERY-QNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 P Y N +G G+ G VC A +G VAVKK+ + + + E+ +++ + Sbjct: 149 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQ 206 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQILRGL 138 HENV+ + + + +++++V + G L +IV ++ ++ + + +L+ L Sbjct: 207 HENVVEMYNSYLVG------DELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQAL 260 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVATRWYRAPEIML 195 +H+ +IHRD+K ++ + D +K+ DFG E V T ++ APE ++ Sbjct: 261 SVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LI 319 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 + + Y VDIWS+G ++ E++ G + + +K+I + P + L K+ Sbjct: 320 SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL-PPRLKNLHKV----- 373 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPD 315 +P L+++LV D +R TAA+ L H + A+ P Sbjct: 374 ----------------------SPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA 411 >5D9K-A nrPDB Length = 330 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 77/338 (22%), Positives = 134/338 (39%), Gaps = 61/338 (18%) Query: 21 PERYQNLSPVGSGAYGSVCAAFDT---KTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 P +++ L +G G++G V A+K L + + RT E +L Sbjct: 29 PSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVE 88 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ-KLTDDHVQFLIYQIL 135 + H ++ L F L YL+ + G DL + + T++ V+F + ++ Sbjct: 89 VNHPFIVKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 142 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT---GYVATRWYRAPE 192 L ++HS II+RDLKP N+ ++E+ +K+ DFGL++ + D + T Y APE Sbjct: 143 LALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPE 202 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 + +N + Q+ D WS G +M E+LTG F G D + + +IL+ L Sbjct: 203 V-VNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFL------ 255 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITA-----AQALAHAY 307 +P A LL + + R+ A + H++ Sbjct: 256 -------------------------SPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSF 290 Query: 308 FA----------QYHDPDDEPVADPYDQSFESRDLLID 335 F+ + H P P D + + Sbjct: 291 FSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAK 328 >3Q53-A nrPDB Length = 306 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 133/297 (44%), Gaps = 39/297 (13%) Query: 16 TIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLL 75 ++ + ++Y +G GA G+V A D TG VA+++++ Q + E+ ++ Sbjct: 15 SVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMN--LQQQPKKELIINEILVM 72 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQIL 135 + K+ N++ LD + L ++ +L G L ++V + + + + + L Sbjct: 73 RENKNPNIVNYLDSYLVGDEL-----WVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECL 127 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVATRWYRAPE 192 + L+++HS +IHRD+K N+ + D +K+ DFG E + V T ++ APE Sbjct: 128 QALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 187 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 + + Y VDIWS+G + E++ G + + + L LI GTP + +K+ Sbjct: 188 V-VTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIA-TNGTPELQNPEKL-- 243 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 + + D L + L +D +KR +A + + H + Sbjct: 244 -------------------------SAIFRDFLNRCLEMDVEKRGSAKELIQHQFLK 275 >2Q0N-A nrPDB Length = 301 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 71/300 (23%), Positives = 137/300 (45%), Gaps = 42/300 (14%) Query: 21 PERY-QNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 P Y N +G G+ G VC A +G VAVKK+ + + + E+ +++ + Sbjct: 27 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQ 84 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQILRGL 138 HENV+ + + + +++++V + G L +IV ++ ++ + + +L+ L Sbjct: 85 HENVVEMYNSYLVG------DELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQAL 138 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVATRWYRAPEIML 195 +H+ +IHRD+K ++ + D +K+ DFG E V T ++ APE ++ Sbjct: 139 SVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LI 197 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 + + Y VDIWS+G ++ E++ G + + +K+I + P + L K+ Sbjct: 198 SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL-PPRLKNLHKV----- 251 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPD 315 +P L+++LV D +R TAA+ L H + A+ P Sbjct: 252 ----------------------SPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA 289 >4JDH-A nrPDB Length = 346 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 71/300 (23%), Positives = 137/300 (45%), Gaps = 42/300 (14%) Query: 21 PERY-QNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 P Y N +G G+ G VC A +G VAVKK+ + + + E+ +++ + Sbjct: 72 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQ 129 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQILRGL 138 HENV+ + + + +++++V + G L +IV ++ ++ + + +L+ L Sbjct: 130 HENVVEMYNSYLVG------DELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQAL 183 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVATRWYRAPEIML 195 +H+ +IHRD+K ++ + D +K+ DFG E V T ++ APE ++ Sbjct: 184 SVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LI 242 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 + + Y VDIWS+G ++ E++ G + + +K+I + P + L K+ Sbjct: 243 SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL-PPRLKNLHKV----- 296 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPD 315 +P L+++LV D +R TAA+ L H + A+ P Sbjct: 297 ----------------------SPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA 334 >3MV5-A nrPDB Length = 342 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 82/350 (23%), Positives = 148/350 (42%), Gaps = 52/350 (14%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ-SIIHAKRTYRELRLLKHMKHE 81 ++ L +G G +G V + TG A+K L + + T E R+L++ +H Sbjct: 11 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 70 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGLKY 140 + L F L +++ + G +L + ++ ++D +F +I+ L Y Sbjct: 71 FLTALKYSFQTHDRL-----CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 125 Query: 141 IHS-ADIIHRDLKPSNLAVNEDCELKILDFGLARH---TDDEMTGYVATRWYRAPEIMLN 196 +HS ++++RDLK NL +++D +KI DFGL + M + T Y APE++ + Sbjct: 126 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 185 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 256 Y + VD W +G +M E++ GR F DH +LIL Sbjct: 186 N-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-------------------- 224 Query: 257 NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQALAHAYFA-- 309 M ++ F P A LL +L D +R+ A + + H +FA Sbjct: 225 --------MEEIRFPRTL---GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 273 Query: 310 QYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEME 359 + ++ ++ P+ S + + ++I+ PP D + ME Sbjct: 274 VWQHVYEKKLSPPFKPQVTS-ETDTRYFDEEFTAQMITITPPDQD-DSME 321 >4XBR-A nrPDB Length = 366 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 71/300 (23%), Positives = 137/300 (45%), Gaps = 42/300 (14%) Query: 21 PERY-QNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 P Y N +G G+ G VC A +G VAVKK+ + + + E+ +++ + Sbjct: 92 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQ 149 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQILRGL 138 HENV+ + + + +++++V + G L +IV ++ ++ + + +L+ L Sbjct: 150 HENVVEMYNSYLVG------DELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQAL 203 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVATRWYRAPEIML 195 +H+ +IHRD+K ++ + D +K+ DFG E V T ++ APE ++ Sbjct: 204 SVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LI 262 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 + + Y VDIWS+G ++ E++ G + + +K+I + P + L K+ Sbjct: 263 SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL-PPRLKNLHKV----- 316 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPD 315 +P L+++LV D +R TAA+ L H + A+ P Sbjct: 317 ----------------------SPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA 354 >1ZWS-A nrPDB Length = 288 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 82/302 (27%), Positives = 134/302 (44%), Gaps = 46/302 (15%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP----FQSIIHAKRTYRELRLL 75 V + Y +GSG + V + TGL A K + + + + + RE+ +L Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSIL 69 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV-KCQKLTDDHVQFLIYQ 133 + + H NVI L DV+ E DV L+ L+ G +L + + + + L+++ I Q Sbjct: 70 RQVLHHNVITLHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQ 123 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDC----ELKILDFGLARHTDD--EMTGYVATRW 187 IL G+ Y+H+ I H DLKP N+ + + +K++DFGLA +D E T Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247 + APE ++N+ D+WS+G I LL+G + F G + L I + E Sbjct: 184 FVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEF- 241 Query: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 F + LA D + K+LV ++ KR+T +AL H + Sbjct: 242 --------------------------FSHTSELAKDFIRKLLVKETRKRLTIQEALRHPW 275 Query: 308 FA 309 Sbjct: 276 IT 277 >5KCV-A nrPDB Length = 460 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 136/321 (42%), Gaps = 50/321 (15%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ-SIIHAKRTYRELRLLKHMKHE 81 ++ L +G G +G V + TG A+K L + + T E R+L++ +H Sbjct: 163 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 222 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGLKY 140 + L F L +++ + G +L + ++ ++D +F +I+ L Y Sbjct: 223 FLTALKYSFQTHDRL-----CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 277 Query: 141 IHS-ADIIHRDLKPSNLAVNEDCELKILDFGLARH---TDDEMTGYVATRWYRAPEIMLN 196 +HS ++++RDLK NL +++D +KI DFGL + M + T Y APE++ + Sbjct: 278 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 337 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 256 Y + VD W +G +M E++ GR F DH +LIL Sbjct: 338 N-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-------------------- 376 Query: 257 NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQALAHAYFA-- 309 M ++ F P A LL +L D +R+ A + + H +FA Sbjct: 377 --------MEEIRFPRTL---GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 425 Query: 310 QYHDPDDEPVADPYDQSFESR 330 + ++ ++ P+ S Sbjct: 426 VWQHVYEKKLSPPFKPQVTSE 446 >4PDS-A nrPDB Length = 347 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 84/308 (27%), Positives = 135/308 (43%), Gaps = 53/308 (17%) Query: 22 ERYQNL-SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH 80 + + + VG GA+ +V A + TG +VK +S+ + I + REL +L+ + H Sbjct: 30 KDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKR-KVIGNMDGVTRELEVLQKLNH 88 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK-LTDDHVQFLIYQILRGL 138 ++ L + E+ Y+V + G DL + V + +D + + QIL + Sbjct: 89 PRIVRLKGFY------EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAI 142 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCE--LKILDFGLARHTDDE--MTGYVATRWYRAPEIM 194 KYIHS I HRDLKP N+ + +D +KI FGLA+ + M + T Y APE++ Sbjct: 143 KYIHSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVI 202 Query: 195 LN------------WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 242 Y+ VD+WS+GC++ +LTG F G+ K I R G+ Sbjct: 203 RGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGR--GSY 260 Query: 243 GAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQA 302 LK + A D ++ +L +D + R TAA+A Sbjct: 261 HEGPLKDFR-------------------------ISEEARDFIDSLLQVDPNNRSTAAKA 295 Query: 303 LAHAYFAQ 310 L H + Sbjct: 296 LNHPWIKM 303 >4L42-A nrPDB Length = 346 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 87/356 (24%), Positives = 147/356 (41%), Gaps = 54/356 (15%) Query: 21 PERYQNLSPVGSGAYGSVCAAFDT---KTGLRVAVKKLSRP--FQSIIHAKRTYRELRLL 75 PE ++ L +G G YG V TG A+K L + ++ T E +L Sbjct: 17 PECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL 76 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQI 134 + +KH ++ L+ F L ++ +L G +L ++ + +D F + +I Sbjct: 77 EEVKHPFIVDLIYAFQTGGKL-----YLILEYLSGGELFMQLEREGIFMEDTACFYLAEI 131 Query: 135 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT---GYVATRWYRAP 191 L ++H II+RDLKP N+ +N +K+ DFGL + + + T + T Y AP Sbjct: 132 SMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAP 191 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 EI++ H N+ VD WS+G +M ++LTG F G + + IL+ Sbjct: 192 EILMRSGH-NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK------------ 238 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQALAHA 306 N+ A DLL+K+L ++ R+ A + AH Sbjct: 239 -------------------LNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHP 279 Query: 307 YFAQ--YHDPDDEPVADPYDQSFESRDLLID-EWKSLTYDEVISFVPPPLDQEEME 359 +F + + V P+ +S + + + K V S L +EE E Sbjct: 280 FFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSEEEQE 335 >5X8I-B nrPDB Length = 346 Score = 240 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 83/324 (25%), Positives = 145/324 (44%), Gaps = 44/324 (13%) Query: 23 RYQNLSPVGSGAYGSVCAAF-DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-- 79 RY+ + +G GA+G V G VAVK + + + + E+++L+H+ Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDR---YCEAARSEIQVLEHLNTT 70 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTD---DHVQFLIYQILR 136 N E + +V L+G + +K DH++ + YQI + Sbjct: 71 DPN--STFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICK 128 Query: 137 GLKYIHSADIIHRDLKPSNLAVNE-------------------DCELKILDFGLARHTDD 177 + ++HS + H DLKP N+ + + ++K++DFG A + D+ Sbjct: 129 SVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDE 188 Query: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 + V+TR YRAPE++L + ++Q D+WS+GCI+ E G T+FP D + L ++ R Sbjct: 189 HHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMER 247 Query: 238 LVGTPGAELLKKISSESARNYIQ-------------SLTQMPKMNFANVFIGANPLAVDL 284 ++G +++K ++ + S P F + DL Sbjct: 248 ILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDL 307 Query: 285 LEKMLVLDSDKRITAAQALAHAYF 308 ++KML D KRIT +AL H +F Sbjct: 308 IQKMLEYDPAKRITLREALKHPFF 331 >6FYV-A nrPDB Length = 337 Score = 240 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 82/325 (25%), Positives = 147/325 (45%), Gaps = 46/325 (14%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTK-TGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH- 80 RY+ + +G GA+G V D G+ VAVK + + + + E+++L+H+ Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGR---YREAARSEIQVLEHLNST 71 Query: 81 -ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTD---DHVQFLIYQILR 136 N + + V +V L+G + +K DH++ + YQI + Sbjct: 72 DPNSV--FRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQ 129 Query: 137 GLKYIHSADIIHRDLKPSNLAVNE-------------------DCELKILDFGLARHTDD 177 + ++H + H DLKP N+ + + ++K++DFG A + D+ Sbjct: 130 SINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDE 189 Query: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 + V+TR YRAPE++L + ++Q D+WS+GCI+ E G T+F D + L ++ R Sbjct: 190 HHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMER 248 Query: 238 LVGTPGAELLKKISS--------------ESARNYIQSLTQMPKMNFANVFIGANPLAVD 283 ++G +++K SA Y++ + P F + D Sbjct: 249 ILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCK-PLKEFMLCHDEEHEKLFD 307 Query: 284 LLEKMLVLDSDKRITAAQALAHAYF 308 L+ +ML D +RIT +AL H +F Sbjct: 308 LVRRMLEYDPTQRITLDEALQHPFF 332 >3DB8-A nrPDB Length = 317 Score = 240 bits (614), Expect = 6e-64, Method: Composition-based stats. Identities = 82/333 (24%), Positives = 139/333 (41%), Gaps = 53/333 (15%) Query: 3 QERPTFYRQELNKTIWEVPE---------RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVK 53 +P+ + + + E+P+ RY +G G + D T A K Sbjct: 14 SAKPSAHVDPKSAPLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGK 73 Query: 54 KLSRPFQSIIHAKRTYR-ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA- 111 + + H K E+ + K + + +V+G F E+ + VY+V + Sbjct: 74 VVPKSMLLKPHQKEKMSTEIAIHKSLDNPHVVGFHGFF------EDDDFVYVVLEICRRR 127 Query: 112 DLNNIVKCQK-LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFG 170 L + K +K +T+ ++ + Q ++G++Y+H+ +IHRDLK NL +N+D ++KI DFG Sbjct: 128 SLLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFG 187 Query: 171 LARHT---DDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTD 227 LA + T Y APE++ H + VDIWS+GCI+ LL G+ F + Sbjct: 188 LATKIEFDGERKKDLCGTPNYIAPEVLCKKGH-SFEVDIWSLGCILYTLLVGKPPFETSC 246 Query: 228 HIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEK 287 + I K N +V NP+A L+ + Sbjct: 247 LKETYIRI-------------------------------KKNEYSVPRHINPVASALIRR 275 Query: 288 MLVLDSDKRITAAQALAHAYFAQYHDPDDEPVA 320 ML D R + A+ L +F + P P + Sbjct: 276 MLHADPTLRPSVAELLTDEFFTSGYAPMRLPTS 308 >6CKI-A nrPDB Length = 316 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 79/322 (24%), Positives = 132/322 (40%), Gaps = 41/322 (12%) Query: 20 VPERYQNLS-PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 + YQ +G GA+ V + T AVK + + I R +RE+ +L Sbjct: 10 FEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHI--RSRVFREVEMLYQC 67 Query: 79 K-HENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQIL 135 + H N V EE + YLV M G+ L++I K + + ++ + Sbjct: 68 QGHRN------VLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVA 121 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCE---LKILDFGLARHT----------DDEMTGY 182 L ++H+ I HRDLKP N+ + +KI DFGL E+ Sbjct: 122 SALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTP 181 Query: 183 VATRWYRAPEIMLNWMH----YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL 238 + Y APE++ + Y++ D+WS+G I+ LL+G F G D Sbjct: 182 CGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSD-------- 233 Query: 239 VGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT 298 G E + + + + P ++A++ + A DL+ K+LV D+ +R++ Sbjct: 234 CGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHI----SCAAKDLISKLLVRDAKQRLS 289 Query: 299 AAQALAHAYFAQYHDPDDEPVA 320 AAQ L H + + P Sbjct: 290 AAQVLQHPWVQGCAPENTLPTP 311 >1KOB-A nrPDB Length = 387 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 78/346 (22%), Positives = 141/346 (40%), Gaps = 48/346 (13%) Query: 11 QELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR 70 Q + V + Y L +GSGA+G V + TG K ++ P+ + Sbjct: 40 QPVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPY--PLDKYTVKN 97 Query: 71 ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ--KLTDDHVQ 128 E+ ++ + H +I L D F + V ++ L G +L + + + K+++ V Sbjct: 98 EISIMNQLHHPKLINLHDAFEDKYEM-----VLILEFLSGGELFDRIAAEDYKMSEAEVI 152 Query: 129 FLIYQILRGLKYIHSADIIHRDLKPSNLA--VNEDCELKILDFGLARHTDDEMTGYV--A 184 + Q GLK++H I+H D+KP N+ + +KI+DFGLA + + V A Sbjct: 153 NYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTA 212 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGA 244 T + APE +++ D+W++G + LL+G + F G D ++ L+ + R Sbjct: 213 TAEFAAPE-IVDREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDE 271 Query: 245 ELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304 + F +P A D ++ +L + KR+T AL Sbjct: 272 ---------------------------DAFSSVSPEAKDFIKNLLQKEPRKRLTVHDALE 304 Query: 305 HAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVP 350 H + H ++ + SR I + Y + + P Sbjct: 305 HPWLKGDH-------SNLTSRIPSSRYNKIRQKIKEKYADWPAPQP 343 >2UV2-A nrPDB Length = 325 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 72/350 (20%), Positives = 141/350 (40%), Gaps = 52/350 (14%) Query: 4 ERPTFYRQEL----NKTIWEVPERY-QNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP 58 Y Q + + T PE + + + +G GA+G V A + +T + A K + Sbjct: 14 GTENLYFQSMKQYEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVI--D 71 Query: 59 FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK 118 +S + E+ +L H N++ LLD F E N L+ G ++ ++ Sbjct: 72 TKSEEELEDYMVEIDILASCDHPNIVKLLDAFY-----YENNLWILIEFCAGGAVDAVML 126 Query: 119 C--QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD 176 + LT+ +Q + Q L L Y+H IIHRDLK N+ D ++K+ DFG++ Sbjct: 127 ELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNT 186 Query: 177 ---DEMTGYVATRWYRAPEIML----NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI 229 ++ T ++ APE+++ Y+ D+WS+G + E+ + Sbjct: 187 RTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPP---HHEL 243 Query: 230 DQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKML 289 + ++++L++ + L + + D L+K L Sbjct: 244 NPMRVLLKIAKSEPPTLAQ-------------------------PSRWSSNFKDFLKKCL 278 Query: 290 VLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKS 339 + D R T +Q L H + ++P+ + ++ +++ K Sbjct: 279 EKNVDARWTTSQLLQHPFVTV---DSNKPIRELIAEAKAEVTEEVEDGKE 325 >2JDO-A nrPDB Length = 342 Score = 239 bits (610), Expect = 1e-63, Method: Composition-based stats. Identities = 76/320 (23%), Positives = 135/320 (42%), Gaps = 49/320 (15%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ-SIIHAKRTYRELRLLKHMKHE 81 + L +G G +G V + TG A+K L + + T E R+L++ +H Sbjct: 11 DFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHP 70 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGLKY 140 + L F L +++ + G +L + ++ T++ +F +I+ L+Y Sbjct: 71 FLTALKYAFQTHDRL-----CFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEY 125 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFGLARH---TDDEMTGYVATRWYRAPEIMLNW 197 +HS D+++RD+K NL +++D +KI DFGL + M + T Y APE++ + Sbjct: 126 LHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDN 185 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 Y + VD W +G +M E++ GR F DH +LIL Sbjct: 186 -DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL--------------------- 223 Query: 258 YIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQALAHAYFAQ-- 310 M ++ F +P A LL +L D +R+ A + + H +F Sbjct: 224 -------MEEIRFPRTL---SPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSIN 273 Query: 311 YHDPDDEPVADPYDQSFESR 330 + D + + P+ S Sbjct: 274 WQDVVQKKLLPPFKPQVTSE 293 >4QMW-A nrPDB Length = 310 Score = 238 bits (608), Expect = 3e-63, Method: Composition-based stats. Identities = 68/301 (22%), Positives = 118/301 (39%), Gaps = 43/301 (14%) Query: 11 QELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR 70 Q L E+ + L +G G++G V D +T VA+K + + Sbjct: 21 QNLKADPEEL---FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIED-IQQ 76 Query: 71 ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL 130 E+ +L V + L ++ +L G ++++ L + + + Sbjct: 77 EITVLSQCDSPYVTKYYGSYLKDTKL-----WIIMEYLGGGSALDLLEPGPLDETQIATI 131 Query: 131 IYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD---EMTGYVATRW 187 + +IL+GL Y+HS IHRD+K +N+ ++E E+K+ DFG+A D + +V T + Sbjct: 132 LREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPF 191 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247 + APE++ Y+ DIWS+G EL G + L LI Sbjct: 192 WMAPEVI-KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLI------------ 238 Query: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 PK N + + + +E L + R TA + L H + Sbjct: 239 ------------------PKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 280 Query: 308 F 308 Sbjct: 281 I 281 >4I6B-A nrPDB Length = 308 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 75/305 (24%), Positives = 126/305 (41%), Gaps = 42/305 (13%) Query: 21 PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH-AKRTYRELRLLKHMK 79 +RY +G G + D A K + S H ++ +E+ L + + Sbjct: 27 GKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILH 86 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGL 138 H++V+ F ++ L+ + + +I+K +K LT+ V++ + QI+ GL Sbjct: 87 HKHVVQFYHYFEDKENI-----YILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGL 141 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD---DEMTGYVATRWYRAPEIML 195 KY+H +I+HRDLK N +NE ELK+ DFGLA + T Y +PE++ Sbjct: 142 KYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL- 200 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 N + DIW++GC+M +L GR F T+ + + I T + LL Sbjct: 201 NKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAP------ 254 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPD 315 A L+ ML + + R + + H +F Q PD Sbjct: 255 -------------------------AKHLIASMLSKNPEDRPSLDDIIRHDFFTQGFTPD 289 Query: 316 DEPVA 320 + Sbjct: 290 RLSSS 294 >6O6Q-A nrPDB Length = 335 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 85/318 (26%), Positives = 162/318 (50%), Gaps = 20/318 (6%) Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60 +S + +++ + W E Y+ L +G G Y V D + +V +K L Sbjct: 20 LSTKPQSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLK---- 75 Query: 61 SIIHAKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC 119 + K+ RE+ +LK++ N+I +LDV +S + H+ D ++ Sbjct: 76 -PVKRKKIKREISILKNLVDGPNIIAMLDVVREPQS---KTPGLIFEHINNIDFRSLY-- 129 Query: 120 QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE-LKILDFGLAR--HTD 176 TD ++F +Y++L+ L Y HS I+HRD+KP N+ ++ D + L+++D+GLA H Sbjct: 130 PTFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPG 189 Query: 177 DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAEL-LTGRTLFPGTDHIDQLKLI 235 E VA+R+++ PE+++++ Y+ ++D+WS GC++A + F G + DQL I Sbjct: 190 TEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQI 249 Query: 236 LRLVGTPGAELLKKISSESARNYIQSLTQMPKMNF-----ANVFIGANPLAVDLLEKMLV 290 +R++G+ + + + S + + K + N + +DL++++L Sbjct: 250 VRVLGSKNFKKYLEKYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLR 309 Query: 291 LDSDKRITAAQALAHAYF 308 D +R+TA +A+ HAYF Sbjct: 310 YDHQERLTAKEAMKHAYF 327 >2XIK-A nrPDB Length = 294 Score = 237 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 65/296 (21%), Positives = 120/296 (40%), Gaps = 40/296 (13%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E + L +G G++G V D T VA+K + +E+ +L Sbjct: 19 ELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIED-IQQEITVLSQCDSP 77 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 + + + L ++ +L G +++K L + ++ ++ +IL+GL Y+ Sbjct: 78 YITRYFGSYLKSTKL-----WIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYL 132 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD---EMTGYVATRWYRAPEIMLNWM 198 HS IHRD+K +N+ ++E ++K+ DFG+A D + +V T ++ APE++ Sbjct: 133 HSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-KQS 191 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY 258 Y+ DIWS+G EL G S + Sbjct: 192 AYDFKADIWSLGITAIELAKGEPP------------------------------NSDLHP 221 Query: 259 IQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 314 ++ L +PK + + + + +E L D R TA + L H + +Y Sbjct: 222 MRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKK 277 >4FZF-B nrPDB Length = 283 Score = 237 bits (605), Expect = 6e-63, Method: Composition-based stats. Identities = 63/292 (21%), Positives = 113/292 (38%), Gaps = 40/292 (13%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E + L +G G++G V D +T VA+K + +E+ +L Sbjct: 8 ELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIED-IQQEITVLSQCDSS 66 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 V + L ++ +L G ++++ + + ++ +IL+GL Y+ Sbjct: 67 YVTKYYGSYLKGSKL-----WIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 121 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD---EMTGYVATRWYRAPEIMLNWM 198 HS IHRD+K +N+ ++E ++K+ FG+A D + +V T ++ APE++ Sbjct: 122 HSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQS- 180 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY 258 Y+ DIWS+G EL G + L LI Sbjct: 181 AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLI----------------------- 217 Query: 259 IQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 PK N + + ++ L D R TA + L H + + Sbjct: 218 -------PKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVK 262 >4RLP-A nrPDB Length = 288 Score = 237 bits (605), Expect = 6e-63, Method: Composition-based stats. Identities = 77/304 (25%), Positives = 129/304 (42%), Gaps = 51/304 (16%) Query: 21 PERYQNLSPVGSGAYGSVCAAFDT---KTGLRVAVKKLSRP--FQSIIHAKRTYRELRLL 75 PE ++ L +G G YG V TG A+K L + ++ T E +L Sbjct: 4 PECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL 63 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQI 134 + +KH ++ L+ F L ++ +L G +L ++ + +D F + +I Sbjct: 64 EEVKHPFIVDLIYAFQTGGKL-----YLILEYLSGGELFMQLEREGIFMEDTACFYLAEI 118 Query: 135 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT---GYVATRWYRAP 191 L ++H II+RDLKP N+ +N +K+ DFGL + + + T + T Y AP Sbjct: 119 SMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAP 178 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 EI++ H N+ VD WS+G +M ++LTG F G + + IL+ Sbjct: 179 EILMRSGH-NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK------------ 225 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQALAHA 306 N+ A DLL+K+L ++ R+ A + AH Sbjct: 226 -------------------LNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHP 266 Query: 307 YFAQ 310 +F Sbjct: 267 FFRH 270 >2Z7Q-A nrPDB Length = 321 Score = 237 bits (604), Expect = 7e-63, Method: Composition-based stats. Identities = 75/322 (23%), Positives = 132/322 (40%), Gaps = 53/322 (16%) Query: 21 PERYQNLSPVGSGAYGSVCAAFDT---KTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 P ++ L +G G++G V +G A+K L + + RT E +L Sbjct: 27 PSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILAD 86 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ-KLTDDHVQFLIYQIL 135 + H V+ L F L YL+ + G DL + + T++ V+F + ++ Sbjct: 87 VNHPFVVKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 140 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT---GYVATRWYRAPE 192 GL ++HS II+RDLKP N+ ++E+ +K+ DFGL++ D + T Y APE Sbjct: 141 LGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPE 200 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 + +N ++ + D WS G +M E+LTG F G D + + LIL+ L Sbjct: 201 V-VNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFL------ 253 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQALAHAY 307 + A LL + + R+ A + H + Sbjct: 254 -------------------------STEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVF 288 Query: 308 FA--QYHDPDDEPVADPYDQSF 327 ++ ++ + P+ + Sbjct: 289 YSTIDWNKLYRREIKPPFKPAV 310 >2X4F-A nrPDB Length = 373 Score = 237 bits (604), Expect = 8e-63, Method: Composition-based stats. Identities = 80/315 (25%), Positives = 140/315 (44%), Gaps = 43/315 (13%) Query: 28 SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLL 87 +G G +G V +T TGL++A K + + + + E+ ++ + H N+I L Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIK--TRGMKDKEEVKNEISVMNQLDHANLIQLY 152 Query: 88 DVFTPARSLEEFNDVYLVTHLM-GADLNNIV--KCQKLTDDHVQFLIYQILRGLKYIHSA 144 D F E ND+ LV + G +L + + + LT+ + QI G++++H Sbjct: 153 DAF------ESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQM 206 Query: 145 DIIHRDLKPSNLA-VNEDC-ELKILDFGLARHTDDEMTGYV--ATRWYRAPEIMLNWMHY 200 I+H DLKP N+ VN D ++KI+DFGLAR V T + APE+ +N+ Sbjct: 207 YILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEV-VNYDFV 265 Query: 201 NQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQ 260 + D+WSVG I LL+G + F G + + L IL E + I Sbjct: 266 SFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDI---------- 315 Query: 261 SLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVA 320 + A + + K+L+ + RI+A++AL H + + + Sbjct: 316 -----------------SEEAKEFISKLLIKEKSWRISASEALKHPWLSDHKLHSRLSAQ 358 Query: 321 DPYDQSFESRDLLID 335 ++ +++D + Sbjct: 359 KKKNRGSDAQDFVTK 373 >5DBX-A nrPDB Length = 328 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 75/307 (24%), Positives = 124/307 (40%), Gaps = 46/307 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 + Y+ +GSGA V AA RVA+K+++ + +E++ + H Sbjct: 11 DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLE-KCQTSMDELLKEIQAMSQCSHP 69 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVK---------CQKLTDDHVQFLI 131 NV+ F ++++LV L+ G + +I+K L + + ++ Sbjct: 70 NVVTYYTSFVVK------DELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATIL 123 Query: 132 YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT--------DDEMTGYV 183 ++L GL Y+H IHRDLK N+ + ED ++I DFG++ + +V Sbjct: 124 KEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFV 183 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPG 243 T + APE+M Y+ D+WS G EL TG + + L +L L P Sbjct: 184 GTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVL--MLTLQNDPP 241 Query: 244 AELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQAL 303 E + Y +S + LL L D KR TAA+ L Sbjct: 242 TLETGVEDKEMMKKYGKSFRK-------------------LLSLCLQKDPSKRPTAAELL 282 Query: 304 AHAYFAQ 310 +F + Sbjct: 283 KCKFFQK 289 >6FDY-U nrPDB Length = 276 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 75/311 (24%), Positives = 132/311 (42%), Gaps = 44/311 (14%) Query: 14 NKTIWEVP--ERYQNLSPVGSGAYGSVCAAF-DTKTGLRVAVKKLSRPFQSIIHAKRTYR 70 W P + + +GSG Y +V A+ T VA+K +++ + + Sbjct: 1 AGPGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLT 60 Query: 71 ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK-LTDDHVQ 128 E+ +LK ++H +++ L D + +++YL+ G DL+ + ++ L + + Sbjct: 61 EIEILKGIRHPHIVQLKDFQW------DSDNIYLIMEFCAGGDLSRFIHTRRILPEKVAR 114 Query: 129 FLIYQILRGLKYIHSADIIHRDLKPSNLAVN--EDCELKILDFGLARHTD--DEMTGYVA 184 + Q+ L+++H +I H DLKP N+ ++ E LK+ DFG A+H DE Sbjct: 115 VFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRG 174 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGA 244 + Y APE M+ Y+ VD+WS+G I+ E L G+ F + + I Sbjct: 175 SPLYMAPE-MVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIR-------- 225 Query: 245 ELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304 N + L P + DLL+++L D +RI+ A Sbjct: 226 -----------SNRVIELPLRP---------LLSRDCRDLLQRLLERDPSRRISFQDFFA 265 Query: 305 HAYFAQYHDPD 315 H + H P Sbjct: 266 HPWVDLEHMPS 276 >3HDN-A nrPDB Length = 373 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 73/320 (22%), Positives = 137/320 (42%), Gaps = 49/320 (15%) Query: 21 PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKL-SRPFQSIIHAKRTYRELRLL-KHM 78 P + L +G G++G V A + AVK L + K E +L K++ Sbjct: 37 PSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNV 96 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRG 137 KH ++GL F A L +++ ++ G +L ++ ++ + +F +I Sbjct: 97 KHPFLVGLHFSFQTADKL-----YFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 151 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT---DDEMTGYVATRWYRAPEIM 194 L Y+HS +I++RDLKP N+ ++ + + DFGL + + + + T Y APE++ Sbjct: 152 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 211 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 + Y++TVD W +G ++ E+L G F + + IL +L I++ Sbjct: 212 -HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNK----PLQLKPNITN-- 264 Query: 255 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA----QALAHAYFA- 309 A LLE +L D KR+ A + +H +F+ Sbjct: 265 -------------------------SARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSL 299 Query: 310 -QYHDPDDEPVADPYDQSFE 328 + D ++ + P++ + Sbjct: 300 INWDDLINKKITPPFNPNVS 319 >6CMJ-A nrPDB Length = 321 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 73/336 (21%), Positives = 137/336 (40%), Gaps = 54/336 (16%) Query: 6 PTFYRQELNKTIWEVPE-----RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF- 59 Y Q + +I + + +Y +G G+YG V A++ A+K LS+ Sbjct: 13 ENLYFQGHHVSITGMQDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKL 72 Query: 60 --------QSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG- 110 Q ++ Y+E+ +LK + H NV+ L++V + +Y+V L+ Sbjct: 73 IRQAGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDP----NEDHLYMVFELVNQ 128 Query: 111 ADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFG 170 + + + L++D +F +++G++Y+H IIHRD+KPSNL V ED +KI DFG Sbjct: 129 GPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFG 188 Query: 171 LA---RHTDDEMTGYVATRWYRAPEIMLNWMHY--NQTVDIWSVGCIMAELLTGRTLFPG 225 ++ + +D ++ V T + APE + + +D+W++G + + G+ F Sbjct: 189 VSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMD 248 Query: 226 TDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLL 285 + I + DL+ Sbjct: 249 ERIMCLHSKIKSQALEFPDQ-----------------------------PDIAEDLKDLI 279 Query: 286 EKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAD 321 +ML + + RI + H + + H + P D Sbjct: 280 TRMLDKNPESRIVVPEIKLHPWVTR-HGAEPLPSED 314 >4U41-A nrPDB Length = 332 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 76/332 (22%), Positives = 128/332 (38%), Gaps = 46/332 (13%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM-KHEN 82 ++ + VG+G YG V KTG A+K + K E+ +LK H N Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIK---LEINMLKKYSHHRN 82 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMGA----DLNNIVKCQKLTDDHVQFLIYQILRGL 138 + F + ++LV GA DL K L +D + ++ +ILRGL Sbjct: 83 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 142 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD---DEMTGYVATRWYRAPEIML 195 ++H +IHRD+K N+ + E+ E+K++DFG++ D ++ T ++ APE++ Sbjct: 143 AHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 202 Query: 196 NWMH----YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 + Y+ D+WS G E+ G + L LI R P L K Sbjct: 203 CDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPR---NPPPRLKSKKW 259 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311 S+ ++ +E LV + +R + Q L H + Sbjct: 260 SKKFFSF--------------------------IEGCLVKNYMQRPSTEQLLKHPFIRD- 292 Query: 312 HDPDDEPVADPYDQSFESRDLLIDEWKSLTYD 343 P++ V + E Y+ Sbjct: 293 -QPNERQVRIQLKDHIDRTRKKRGEKDETEYE 323 >2OU7-A nrPDB Length = 335 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 80/297 (26%), Positives = 126/297 (42%), Gaps = 44/297 (14%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR-ELRLLKHMKHENVIGLLD 88 +G G + D T A K + + H + E+ + + + H++V+G Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 89 VFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQK-LTDDHVQFLIYQILRGLKYIHSADI 146 F E+ + V++V L L + K +K LT+ ++ + QI+ G +Y+H + Sbjct: 109 FF------EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 162 Query: 147 IHRDLKPSNLAVNEDCELKILDFGLARHT---DDEMTGYVATRWYRAPEIMLNWMHYNQT 203 IHRDLK NL +NED E+KI DFGLA + T Y APE++ H + Sbjct: 163 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH-SFE 221 Query: 204 VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLT 263 VD+WS+GCIM LL G+ F + + I Sbjct: 222 VDVWSIGCIMYTLLVGKPPFETSCLKETYLRI---------------------------- 253 Query: 264 QMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVA 320 K N ++ NP+A L++KML D R T + L +F + P P+ Sbjct: 254 ---KKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPIT 307 >3TXO-A nrPDB Length = 353 Score = 234 bits (596), Expect = 6e-62, Method: Composition-based stats. Identities = 72/349 (20%), Positives = 135/349 (38%), Gaps = 63/349 (18%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSIIHAKRTYRELRLLKHMK- 79 + ++ + +G G++G V A +TG AVK L + + T E R+L + Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGL 138 H + L F L +++ + G DL +I K ++ + +F +I+ L Sbjct: 83 HPFLTQLFCCFQTPDRL-----FFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISAL 137 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH---TDDEMTGYVATRWYRAPEIML 195 ++H II+RDLK N+ ++ + K+ DFG+ + + T Y APEI+ Sbjct: 138 MFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEIL- 196 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 M Y VD W++G ++ E+L G F + D + IL Sbjct: 197 QEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN------------------ 238 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-TAAQ-----ALAHAYFA 309 + + A +L+ + + R+ + Q L H +F Sbjct: 239 -------------DEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFK 285 Query: 310 Q--YHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQE 356 + + + + P+ +SR+ +V +F P + +E Sbjct: 286 EIDWAQLNHRQIEPPFRPRIKSRE------------DVSNFDPDFIKEE 322 >5F9E-A nrPDB Length = 353 Score = 234 bits (596), Expect = 7e-62, Method: Composition-based stats. Identities = 77/317 (24%), Positives = 137/317 (43%), Gaps = 46/317 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSIIHAKRTYRELRLLKHM-K 79 E ++ +G G++G V A KT A+K L + + T E R+L + Sbjct: 19 EDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWE 78 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGL 138 H + + F +L +++ +L G DL +I C K F +I+ GL Sbjct: 79 HPFLTHMFCTFQTKENL-----FFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGL 133 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT---DDEMTGYVATRWYRAPEIML 195 +++HS I++RDLK N+ +++D +KI DFG+ + D + + T Y APEI+L Sbjct: 134 QFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILL 193 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 YN +VD WS G ++ E+L G++ F G D + I ++ + Sbjct: 194 G-QKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI-------------RMDNPFY 239 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA-QALAHAYFAQ--YH 312 +++ A DLL K+ V + +KR+ H F + + Sbjct: 240 PRWLEK------------------EAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWE 281 Query: 313 DPDDEPVADPYDQSFES 329 + + + + P+ +S Sbjct: 282 ELERKEIDPPFRPKVKS 298 >4YNZ-A nrPDB Length = 342 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 80/318 (25%), Positives = 132/318 (41%), Gaps = 45/318 (14%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 Y+ +G G G V T +VA+K ++R S + RE+ +LK ++H +V Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 84 IGLLDVFTPARSLEEFNDVYLV-THLMGADLNNIV-KCQKLTDDHVQFLIYQILRGLKYI 141 + L DV+ E +YLV H+ G +L + + K +LT + QI+ L + Sbjct: 72 LKLHDVY------ENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFC 125 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARHT--DDEMTGYVATRWYRAPEIMLNWMH 199 HS I HRDLKP NL ++E ++I DFG+A D + + Y PE++ + Sbjct: 126 HSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKY 185 Query: 200 YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYI 259 + D+WS G I+ LL G F + L+ + R V Sbjct: 186 DGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVF------------------- 226 Query: 260 QSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY-FAQYHDPDDEP 318 ++ P LL M+ +D+ +R+T H + ++P+ E Sbjct: 227 ------------HMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPE- 273 Query: 319 VADPYDQSFESRDLLIDE 336 P + + R L E Sbjct: 274 --QPIPRKVQIRSLPSLE 289 >4J52-A nrPDB Length = 293 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 80/297 (26%), Positives = 126/297 (42%), Gaps = 44/297 (14%) Query: 30 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR-ELRLLKHMKHENVIGLLD 88 +G G + D T A K + + H + E+ + + + H++V+G Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 89 VFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQK-LTDDHVQFLIYQILRGLKYIHSADI 146 F E+ + V++V L L + K +K LT+ ++ + QI+ G +Y+H + Sbjct: 82 FF------EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 135 Query: 147 IHRDLKPSNLAVNEDCELKILDFGLARHT---DDEMTGYVATRWYRAPEIMLNWMHYNQT 203 IHRDLK NL +NED E+KI DFGLA + T Y APE++ H + Sbjct: 136 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH-SFE 194 Query: 204 VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLT 263 VD+WS+GCIM LL G+ F + + I Sbjct: 195 VDVWSIGCIMYTLLVGKPPFETSCLKETYLRI---------------------------- 226 Query: 264 QMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVA 320 K N ++ NP+A L++KML D R T + L +F + P P+ Sbjct: 227 ---KKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPIT 280 >3LM0-A nrPDB Length = 327 Score = 232 bits (591), Expect = 3e-61, Method: Composition-based stats. Identities = 80/338 (23%), Positives = 142/338 (42%), Gaps = 52/338 (15%) Query: 4 ERPTFYRQELNKTIWEVPERYQNL--SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 Y Q + E + L +G G + V TG A K L + + Sbjct: 14 GTENLYFQSM-----ENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRG 68 Query: 62 IIHAKRTYRELRLLKHMKH-ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK-- 118 E+ +L+ K VI L +V+ + + ++ + G ++ ++ Sbjct: 69 QDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEI-----ILILEYAAGGEIFSLCLPE 123 Query: 119 -CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE---DCELKILDFGLARH 174 + ++++ V LI QIL G+ Y+H +I+H DLKP N+ ++ ++KI+DFG++R Sbjct: 124 LAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRK 183 Query: 175 TDD--EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQL 232 E+ + T Y APEI+ N+ D+W++G I LLT + F G D+ + Sbjct: 184 IGHACELREIMGTPEYLAPEIL-NYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETY 242 Query: 233 KLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLD 292 I ++ E F + LA D ++ +LV + Sbjct: 243 LNISQVNVDYSEET---------------------------FSSVSQLATDFIQSLLVKN 275 Query: 293 SDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESR 330 +KR TA L+H++ Q+ D E + P + S S+ Sbjct: 276 PEKRPTAEICLSHSWLQQW---DFENLFHPEETSSSSQ 310 >2WO6-A nrPDB Length = 382 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 84/344 (24%), Positives = 146/344 (42%), Gaps = 52/344 (15%) Query: 14 NKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELR 73 N W +RY+ S +G G++G V A+D VA+K + + E+R Sbjct: 48 NGEKW--MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKN---KKAFLNQAQIEVR 102 Query: 74 LLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL---TDDHVQFL 130 LL+ M + + R N + LV ++ +L ++++ + + + Sbjct: 103 LLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKF 162 Query: 131 IYQILRGLKYIH--SADIIHRDLKPSNLAV--NEDCELKILDFGLARHTDDEMTGYVATR 186 Q+ L ++ IIH DLKP N+ + + +KI+DFG + + Y+ +R Sbjct: 163 AQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSR 222 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 +YR+PE++L M Y+ +D+WS+GCI+ E+ TG LF G + +DQ+ I+ ++G P A + Sbjct: 223 FYRSPEVLLG-MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 281 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGANP--------------------------- 279 L + + AR + + L N G Sbjct: 282 LDQ--APKARKFFEKLPD-GTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGE 338 Query: 280 ---------LAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 314 DL+ +ML D RI AL H++F + D Sbjct: 339 SGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE 382 >4CSV-A nrPDB Length = 275 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 123/299 (41%), Gaps = 50/299 (16%) Query: 16 TIWEVPE-RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRL 74 WE+P +GSG +G V + VAVK L + + + +E ++ Sbjct: 4 DKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLK---EGTMSVEEFLQEAQI 60 Query: 75 LKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVK---CQKLTDDHVQFL 130 +K +KH N++ L V T +Y++T M L + ++ + + + Sbjct: 61 MKKLKHPNLVQLYGVCTKEPP------IYIITEYMSHGSLLDYLRDCEGHTVNAQALLDM 114 Query: 131 IYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD-DEMTGYVATRW-- 187 Q+ G+ Y+ S + IHRDL N V E+ +K+ DFGLAR + DE T ++ Sbjct: 115 AAQVASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPI 174 Query: 188 -YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAE 245 + APE + ++ ++ D+W+ G ++ E+ T G+ +PG + ++ + R P + Sbjct: 175 KWTAPEAI-SYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQ 233 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304 G +L+ + ++R T A+ L Sbjct: 234 ------------------------------GCPEEIYELMLQCWNKSPEERPTFAETLH 262 >5X3F-B nrPDB Length = 393 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 71/344 (20%), Positives = 139/344 (40%), Gaps = 59/344 (17%) Query: 18 WEVP-------ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTY 69 WE P +++ + +G+G++G V ++G A+K L + + + T Sbjct: 73 WETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTL 132 Query: 70 RELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHV 127 E R+L+ + ++ L S ++ +++Y+V + G +++ + + ++ H Sbjct: 133 NEKRILQAVNFPFLVKL------EFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHA 186 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW 187 +F QI+ +Y+HS D+I+RDLKP NL +++ +++ DFG A+ T Sbjct: 187 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPE 246 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247 Y APEI+L+ YN+ VD W++G ++ E+ G F I + I+ + Sbjct: 247 YLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF- 304 Query: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQA 302 + DLL +L +D KR Sbjct: 305 ------------------------------SSDLKDLLRNLLQVDLTKRFGNLKNGVNDI 334 Query: 303 LAHAYFAQ------YHDPDDEPVADPYDQSFESRDLLIDEWKSL 340 H +FA Y + P + ++ + E + + Sbjct: 335 KNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEI 378 >5XVU-A nrPDB Length = 332 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 89/319 (27%), Positives = 166/319 (52%), Gaps = 21/319 (6%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 +Y + + W P RY+ + +G G Y V +DT+ A + K+ Sbjct: 17 YYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA-----IKVLKPVKKKK 71 Query: 68 TYRELRLLKHMKH-ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDH 126 RE+++L+++ N+I LLD+ + + ++ D + K TD Sbjct: 72 IKREIKILQNLNGGPNIIKLLDIVKDPVT---KTPSLIFEYINNIDFKTLY--PKFTDKD 126 Query: 127 VQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR--HTDDEMTGYV 183 +++ IYQIL+ L Y HS I+HRD+KP N+ ++ E+ +++++ +GLA H E V Sbjct: 127 IRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRV 186 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTL-FPGTDHIDQLKLILRLVGTP 242 A+R+Y+ PE++++ Y+ ++DIWS+GC++A ++ + F G D+ DQL I +++GT Sbjct: 187 ASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTE 246 Query: 243 GAE-LLKKISSESARNYIQSLTQMPKMNFANVFIGAN-----PLAVDLLEKMLVLDSDKR 296 LKK + + +Y+ L + + +++ +N +DL++KML+ D KR Sbjct: 247 DLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKR 306 Query: 297 ITAAQALAHAYFAQYHDPD 315 I +A+ H YF + + Sbjct: 307 IAPKEAMEHPYFREVREES 325 >4WB7-A nrPDB Length = 405 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 72/344 (20%), Positives = 140/344 (40%), Gaps = 59/344 (17%) Query: 18 WEVP-------ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTY 69 WE P ++++ + +G+G++G V +TG A+K L + + + T Sbjct: 85 WESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTL 144 Query: 70 RELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHV 127 E R+L+ + ++ L S ++ +++Y+V + G +++ + + ++ H Sbjct: 145 NEKRILQAVNFPFLVKL------EFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHA 198 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW 187 +F QI+ +Y+HS D+I+RDLKP NL +++ +++ DFG A+ T Sbjct: 199 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPE 258 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247 Y APEI+L+ YN+ VD W++G ++ E+ G F I + I+ + Sbjct: 259 YLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF- 316 Query: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQA 302 + DLL +L +D KR Sbjct: 317 ------------------------------SSDLKDLLRNLLQVDLTKRFGNLKNGVNDI 346 Query: 303 LAHAYFAQ------YHDPDDEPVADPYDQSFESRDLLIDEWKSL 340 H +FA Y + P + ++ + E + + Sbjct: 347 KNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEI 390 >6HXF-B nrPDB Length = 302 Score = 227 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 68/321 (21%), Positives = 136/321 (42%), Gaps = 52/321 (16%) Query: 1 MSQERP-TFYRQELNKT-IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP 58 M + R R++L+ +WE+ + +G GA+G V A + +TG A K + Sbjct: 2 MRKSREYEHVRRDLDPNEVWEI------VGELGDGAFGKVYKAKNKETGALAAAKVI--E 53 Query: 59 FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK 118 +S + E+ +L H ++ LL + L ++ G ++ I+ Sbjct: 54 TKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKL-----WIMIEFCPGGAVDAIML 108 Query: 119 C--QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--- 173 + LT+ +Q + Q+L L ++HS IIHRDLK N+ + + ++++ DFG++ Sbjct: 109 ELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNL 168 Query: 174 HTDDEMTGYVATRWYRAPEIM----LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI 229 T + ++ T ++ APE++ + Y+ DIWS+G + E+ + Sbjct: 169 KTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPP---HHEL 225 Query: 230 DQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKML 289 + ++++L++ + LL + D L+ L Sbjct: 226 NPMRVLLKIAKSDPPTLL-------------------------TPSKWSVEFRDFLKIAL 260 Query: 290 VLDSDKRITAAQALAHAYFAQ 310 + + R +AAQ L H + + Sbjct: 261 DKNPETRPSAAQLLEHPFVSS 281 >3ORZ-A nrPDB Length = 316 Score = 227 bits (578), Expect = 7e-60, Method: Composition-based stats. Identities = 74/313 (23%), Positives = 122/313 (38%), Gaps = 48/313 (15%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP-FQSIIHAKRTYRELRLLKHMKH 80 E ++ +G G++ +V A + T A+K L + RE ++ + H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKY 140 + L F L L G L I K + +F +I+ L+Y Sbjct: 97 PFFVKLYFCFQDDEKL----YFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEY 152 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT-----GYVATRWYRAPEIML 195 +H IIHRDLKP N+ +NED ++I DFG A+ E +V T Y +PE++ Sbjct: 153 LHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT 212 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 ++ D+W++GCI+ +L+ G F + + I++L + K Sbjct: 213 EKSAC-KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK------ 265 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQ------ALAHAYFA 309 A DL+EK+LVLD+ KR+ + AH +F Sbjct: 266 -------------------------ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFE 300 Query: 310 QYHDPDDEPVADP 322 + P Sbjct: 301 SVTWENLHQQTPP 313 >1U5R-A nrPDB Length = 348 Score = 227 bits (578), Expect = 8e-60, Method: Composition-based stats. Identities = 75/333 (22%), Positives = 139/333 (41%), Gaps = 46/333 (13%) Query: 21 PER-YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLS-RPFQSIIHAKRTYRELRLLKHM 78 PE+ + +L +G G++G+V A D + VA+KK+S QS + +E+R L+ + Sbjct: 52 PEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL 111 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV--KCQKLTDDHVQFLIYQILR 136 +H N I + + +LV ++++ + L + + + + L+ Sbjct: 112 RHPNTIQYRGCYLRE------HTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQ 165 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIML- 195 GL Y+HS ++IHRD+K N+ ++E +K+ DFG A +V T ++ APE++L Sbjct: 166 GLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS-IMAPANSFVGTPYWMAPEVILA 224 Query: 196 -NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 + Y+ VD+WS+G EL + +++ + + + L SE Sbjct: 225 MDEGQYDGKVDVWSLGITCIELAERKPPLF---NMNAMSALYHIAQNESPALQSGHWSEY 281 Query: 255 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 314 RN++ S L R T+ L H + + P Sbjct: 282 FRNFVDS--------------------------CLQKIPQDRPTSEVLLKHRFVLRERPP 315 Query: 315 ---DDEPVADPYDQSFESRDLLIDEWKSLTYDE 344 D + D E +L + K + + E Sbjct: 316 TVIMDL-IQRTKDAVRELDNLQYRKMKKILFQE 347 >3KN6-A nrPDB Length = 325 Score = 227 bits (578), Expect = 8e-60, Method: Composition-based stats. Identities = 75/304 (24%), Positives = 136/304 (44%), Gaps = 41/304 (13%) Query: 28 SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-HENVIGL 86 P+G G++ K+ AVK +S+ ++ T +E+ LK + H N++ L Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEA-----NTQKEITALKLCEGHPNIVKL 71 Query: 87 LDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSA 144 +VF + +LV L+ G I K + ++ +++ +++ + ++H Sbjct: 72 HEVF------HDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDV 125 Query: 145 DIIHRDLKPSNLAV---NEDCELKILDFGLARHTDDE---MTGYVATRWYRAPEIMLNWM 198 ++HRDLKP NL N++ E+KI+DFG AR + + T Y APE +LN Sbjct: 126 GVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE-LLNQN 184 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY 258 Y+++ D+WS+G I+ +L+G+ F D L T E++KKI Sbjct: 185 GYDESCDLWSLGVILYTMLSGQVPFQSHDRS--------LTCTSAVEIMKKIKKGDFS-- 234 Query: 259 IQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEP 318 + NV + A DL++ +L +D +KR+ + + + P Sbjct: 235 ------FEGEAWKNV----SQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNP 284 Query: 319 VADP 322 + P Sbjct: 285 LMTP 288 >4APC-A nrPDB Length = 350 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 72/333 (21%), Positives = 134/333 (40%), Gaps = 52/333 (15%) Query: 4 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII 63 Y Q + E+Y L +G G++G T+ G + +K+++ S Sbjct: 14 GTENLYFQSM--------EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSK 65 Query: 64 HAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK- 121 + + RE+ +L +MKH N++ + F EE +Y+V G DL + QK Sbjct: 66 EREESRREVAVLANMKHPNIVQYRESF------EENGSLYIVMDYCEGGDLFKRINAQKG 119 Query: 122 --LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM 179 +D + QI LK++H I+HRD+K N+ + +D +++ DFG+AR + + Sbjct: 120 VLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTV 179 Query: 180 ---TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 + T +Y +PEI N YN DIW++GC++ EL T + F + + I+ Sbjct: 180 ELARACIGTPYYLSPEICEN-KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKII 238 Query: 237 RLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKR 296 +F V + + L+ ++ + R Sbjct: 239 ------------------------------SGSFPPVSLHYSYDLRSLVSQLFKRNPRDR 268 Query: 297 ITAAQALAHAYFAQYHDPDDEPVADPYDQSFES 329 + L + A+ + P + ++ Sbjct: 269 PSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKT 301 >2GCD-A nrPDB Length = 309 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 75/333 (22%), Positives = 139/333 (41%), Gaps = 46/333 (13%) Query: 21 PER-YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLS-RPFQSIIHAKRTYRELRLLKHM 78 PE+ + +L +G G++G+V A D + VA+KK+S QS + +E+R L+ + Sbjct: 13 PEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL 72 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV--KCQKLTDDHVQFLIYQILR 136 +H N I + + +LV ++++ + L + + + + L+ Sbjct: 73 RHPNTIQYRGCYLRE------HTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQ 126 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIML- 195 GL Y+HS ++IHRD+K N+ ++E +K+ DFG A +V T ++ APE++L Sbjct: 127 GLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS-IMAPANSFVGTPYWMAPEVILA 185 Query: 196 -NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 + Y+ VD+WS+G EL + +++ + + + L SE Sbjct: 186 MDEGQYDGKVDVWSLGITCIELAERKPPLF---NMNAMSALYHIAQNESPALQSGHWSEY 242 Query: 255 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 314 RN++ S L R T+ L H + + P Sbjct: 243 FRNFVDS--------------------------CLQKIPQDRPTSEVLLKHRFVLRERPP 276 Query: 315 ---DDEPVADPYDQSFESRDLLIDEWKSLTYDE 344 D + D E +L + K + + E Sbjct: 277 TVIMDL-IQRTKDAVRELDNLQYRKMKKILFQE 308 >3ALO-A nrPDB Length = 327 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 66/310 (21%), Positives = 124/310 (40%), Gaps = 46/310 (14%) Query: 18 WEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 W+ E ++L +G GAYGSV +G +AVK++ + +++ Sbjct: 17 WDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMR 76 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK------CQKLTDDHVQFL 130 ++ L D ++ LM + K + ++ + + Sbjct: 77 SSDCPYIVQFYGA------LFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKI 130 Query: 131 IYQILRGLKYI-HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM--TGYVATRW 187 ++ L ++ + IIHRD+KPSN+ ++ +K+ DFG++ D + T R Sbjct: 131 TLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRP 190 Query: 188 YRAPEIM---LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI-DQLKLILRLVGTPG 243 Y APE + + Y+ D+WS+G + EL TGR +P + + DQL +++ G P Sbjct: 191 YMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK--GDPP 248 Query: 244 AELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQAL 303 +S+ R + +P ++ + L D KR + L Sbjct: 249 Q-----LSNSEEREF-------------------SPSFINFVNLCLTKDESKRPKYKELL 284 Query: 304 AHAYFAQYHD 313 H + Y + Sbjct: 285 KHPFILMYEE 294 >5DYK-A nrPDB Length = 853 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 70/299 (23%), Positives = 127/299 (42%), Gaps = 43/299 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKL-SRPFQSIIHAKRTYRELRLLKHMKH 80 + + +G G +G+V T +R A+K + R ++ E + H Sbjct: 539 DELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDH 598 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNN-IVKCQKLTDDHVQFLIYQILRGL 138 +I L+ R+ ++ Y +T L+ G +L + I K L+ QF + I+ + Sbjct: 599 PFIIRLV------RTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAI 652 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWM 198 +Y+H +I++RDLKP N+ +++ +K++DFG A+ V T Y APE++L Sbjct: 653 EYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILG-K 711 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY 258 Y TVDIW++G + E + G F G D DQL E R+ Sbjct: 712 GYGCTVDIWALGICLYEFICGPLPF-GNDEEDQL--------------------EIFRDI 750 Query: 259 IQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITA-----AQALAHAYFAQYH 312 + P + +++L++++L RI H +F+ ++ Sbjct: 751 LTGQLTFPDY-------VTDTDSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNFN 802 >5N23-A nrPDB Length = 352 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 72/345 (20%), Positives = 138/345 (40%), Gaps = 60/345 (17%) Query: 18 WEVP-------ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTY 69 WE P ++++ + +G+G++G V +TG A+K L + + + T Sbjct: 31 WESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTL 90 Query: 70 RELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHV 127 E R+ + + ++ L S ++ +++Y+V G +++ + + ++ H Sbjct: 91 NEKRIQQAVNFPFLVKL------EFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHA 144 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT-GYVATR 186 +F QI+ +Y+HS D+I+RDLKP NL +++ +K+ DFG A+ T Sbjct: 145 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWTLCGTP 204 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 Y APEI+L+ YN+ VD W++G ++ E+ G F I + I+ + Sbjct: 205 EYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF 263 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQ 301 + DLL +L +D KR Sbjct: 264 -------------------------------SSDLKDLLRNLLQVDLTKRFGNLKNGVND 292 Query: 302 ALAHAYFAQ------YHDPDDEPVADPYDQSFESRDLLIDEWKSL 340 H +FA Y + P + ++ + E + + Sbjct: 293 IKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEI 337 >6HMD-A nrPDB Length = 365 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 91/325 (28%), Positives = 166/325 (51%), Gaps = 21/325 (6%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 ++ E + W + YQ + +G G Y V A + ++ + K+ Sbjct: 39 YWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNE-----RVVVKILKPVKKKK 93 Query: 68 TYRELRLLKHMKH-ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDH 126 RE+++L++++ N+I L+D S + ++ D + Q LTD Sbjct: 94 IKREVKILENLRGGTNIIKLIDTVKDPVS---KTPALVFEYINNTDFKQLY--QILTDFD 148 Query: 127 VQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE-DCELKILDFGLAR--HTDDEMTGYV 183 ++F +Y++L+ L Y HS I+HRD+KP N+ ++ +L+++D+GLA H E V Sbjct: 149 IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRV 208 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTL-FPGTDHIDQLKLILRLVGTP 242 A+R+++ PE+++++ Y+ ++D+WS+GC++A ++ R F G D+ DQL I +++GT Sbjct: 209 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTE 268 Query: 243 GAE-LLKKISSESARNYIQSLTQMPKMNFANVFIGAN-----PLAVDLLEKMLVLDSDKR 296 LKK + ++ L Q + + N N P A+DLL+K+L D +R Sbjct: 269 ELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQR 328 Query: 297 ITAAQALAHAYFAQYHDPDDEPVAD 321 +TA +A+ H YF +P AD Sbjct: 329 LTAKEAMEHPYFYPVVKEQSQPSAD 353 >1VZO-A nrPDB Length = 355 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 78/323 (24%), Positives = 147/323 (45%), Gaps = 51/323 (15%) Query: 22 ERYQNLSPVGSGAYGSVCAAFD---TKTGLRVAVKKLSRP--FQSIIHAKRTYRELRLLK 76 E ++ L +G+GAYG V TG A+K L + Q + T E ++L+ Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 77 HMK-HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLN-NIVKCQKLTDDHVQFLIYQI 134 H++ ++ L F L ++ ++ G +L ++ + ++ T+ VQ + +I Sbjct: 114 HIRQSPFLVTLHYAFQTETKLH-----LILDYINGGELFTHLSQRERFTEHEVQIYVGEI 168 Query: 135 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT----GYVATRWYRA 190 + L+++H II+RD+K N+ ++ + + + DFGL++ + T + T Y A Sbjct: 169 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMA 228 Query: 191 PEIMLNW-MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 P+I+ +++ VD WS+G +M ELLTG + F T E K Sbjct: 229 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF-----------------TVDGE--KN 269 Query: 250 ISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQALA 304 +E +R ++S P+ + LA DL++++L+ D KR+ A + Sbjct: 270 SQAEISRRILKSEPPYPQ--------EMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKE 321 Query: 305 HAYFAQ--YHDPDDEPVADPYDQ 325 H +F + + D + V P+ Sbjct: 322 HLFFQKINWDDLAAKKVPAPFKP 344 >3RAW-A nrPDB Length = 381 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 75/334 (22%), Positives = 143/334 (42%), Gaps = 42/334 (12%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGL-RVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 + ERY+ + +G G +G V D G +VA+K + + + + E+ +LK + Sbjct: 49 LQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGK---YREAARLEINVLKKI 105 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL---TDDHVQFLIYQIL 135 K ++ + + + L+G + +K HV+ + YQ+ Sbjct: 106 KEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLC 165 Query: 136 RGLKYIHSADIIHRDLKPSNLAVN-------------------EDCELKILDFGLARHTD 176 L+++H + H DLKP N+ ++ +++ DFG A Sbjct: 166 HALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDH 225 Query: 177 DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 + T VATR YR PE++L + + Q D+WS+GCI+ E G TLF ++ + L ++ Sbjct: 226 EHHTTIVATRHYRPPEVIL-ELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMME 284 Query: 237 RLVGTPGAELLKKISSESA--------------RNYIQSLTQMPKMNFANVFIGANPLAV 282 +++G + ++ + + Y++ + P ++ + Sbjct: 285 KILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCK-PLKSYMLQDSLEHVQLF 343 Query: 283 DLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDD 316 DL+ +ML D +RIT A+AL H +FA + Sbjct: 344 DLMRRMLEFDPAQRITLAEALLHPFFAGLTPEER 377 >4MD7-E nrPDB Length = 391 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 95/361 (26%), Positives = 171/361 (47%), Gaps = 25/361 (6%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 ++ E + W + YQ + +G G Y V A + + + + K+ Sbjct: 23 YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVKKKK 77 Query: 68 TYRELRLLKHMKH-ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDH 126 RE+++L++++ N+I L D+ S + H+ D + Q LTD Sbjct: 78 IKREIKILENLRGGPNIITLADIVKDPVS---RTPALVFEHVNNTDFKQLY--QTLTDYD 132 Query: 127 VQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR--HTDDEMTGYV 183 ++F +Y+IL+ L Y HS I+HRD+KP N+ ++ E +L+++D+GLA H E V Sbjct: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRV 192 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTL-FPGTDHIDQLKLILRLVGTP 242 A+R+++ PE+++++ Y+ ++D+WS+GC++A ++ + F G D+ DQL I +++GT Sbjct: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTE 252 Query: 243 GA-ELLKKISSESARNYIQSLTQMPKMNFANVFIGAN-----PLAVDLLEKMLVLDSDKR 296 + + K + E + L + + + N P A+D L+K+L D R Sbjct: 253 DLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSR 312 Query: 297 ITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVP-PPLDQ 355 +TA +A+ H YF Y D+ S + S V P PL Sbjct: 313 LTAREAMEHPYF--YTVVKDQARMGSSSMPGGSEPVSSANMMSGI-SSVPEPEPLGPLAG 369 Query: 356 E 356 E Sbjct: 370 E 370 >4B8L-A nrPDB Length = 286 Score = 224 bits (571), Expect = 6e-59, Method: Composition-based stats. Identities = 60/292 (20%), Positives = 110/292 (37%), Gaps = 42/292 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR-ELRLLKHMKH 80 + + P+G G +G+V A + + +A+K L + + R E+ + H++H Sbjct: 15 DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRH 74 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGL 138 N++ + + F + +YL+ G + K + + + ++ L Sbjct: 75 PNILRMYNYF------HDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADAL 128 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-EMTGYVATRWYRAPEIMLNW 197 Y H +IHRD+KP NL + ELKI DFG + H T Y PE++ Sbjct: 129 HYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGK 188 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 H ++ VD+W G + E L G F H + + I+ + L Sbjct: 189 TH-DEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFL----------- 236 Query: 258 YIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 + + DL+ K+L +R+ + H + Sbjct: 237 --------------------SDGSKDLISKLLRYHPPQRLPLKGVMEHPWVK 268 >5YV8-A nrPDB Length = 298 Score = 224 bits (570), Expect = 7e-59, Method: Composition-based stats. Identities = 67/318 (21%), Positives = 126/318 (39%), Gaps = 63/318 (19%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF----------------------- 59 +Y +G G+YG V A++ A+K LS+ Sbjct: 14 QYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGC 73 Query: 60 -QSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIV 117 Q ++ Y+E+ +LK + H NV+ L++V + +Y+V L+ + + Sbjct: 74 IQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDP----NEDHLYMVFELVNQGPVMEVP 129 Query: 118 KCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA---RH 174 + L++D +F +++G++Y+H IIHRD+KPSNL V ED +KI DFG++ + Sbjct: 130 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKG 189 Query: 175 TDDEMTGYVATRWYRAPEIMLNWMHY--NQTVDIWSVGCIMAELLTGRTLFPGTDHIDQL 232 +D ++ V T + APE + + +D+W++G + + G+ F + Sbjct: 190 SDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLH 249 Query: 233 KLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLD 292 I + DL+ +ML + Sbjct: 250 SKIKSQALEFPDQ-----------------------------PDIAEDLKDLITRMLDKN 280 Query: 293 SDKRITAAQALAHAYFAQ 310 + RI + H + + Sbjct: 281 PESRIVVPEIKLHPWVTR 298 >4CRL-A nrPDB Length = 406 Score = 223 bits (569), Expect = 9e-59, Method: Composition-based stats. Identities = 106/370 (28%), Positives = 164/370 (44%), Gaps = 54/370 (14%) Query: 9 YRQELNKTIWEVPERYQNLS-PVGSGAYGSVCAAFDTKTGLR--VAVKKLSRPFQSIIHA 65 ++ +L+ V + ++ VG G YG V A A+K++ S+ Sbjct: 8 FKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMS-- 65 Query: 66 KRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK---- 121 RE+ LL+ +KH NVI L VF V+L+ DL +I+K + Sbjct: 66 --ACREIALLRELKHPNVISLQKVFLS----HADRKVWLLFDYAEHDLWHIIKFHRASKA 119 Query: 122 ------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV----NEDCELKILDFGL 171 L V+ L+YQIL G+ Y+H+ ++HRDLKP+N+ V E +KI D G Sbjct: 120 NKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGF 179 Query: 172 ARHTDDEMTGY------VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFP- 224 AR + + V T WYRAPE++L HY + +DIW++GCI AELLT +F Sbjct: 180 ARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHC 239 Query: 225 --------GTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPK-------MN 269 H DQL I ++G P + + I + + + Sbjct: 240 RQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKY 299 Query: 270 FANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQS--- 326 + + A LL+K+L +D KRIT+ QA+ YF + D P +D + Sbjct: 300 MEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLE----DPLPTSDVFAGCQIP 355 Query: 327 FESRDLLIDE 336 + R+ L +E Sbjct: 356 YPKREFLTEE 365 >2WTK-C nrPDB Length = 305 Score = 223 bits (569), Expect = 9e-59, Method: Composition-based stats. Identities = 82/330 (24%), Positives = 131/330 (39%), Gaps = 52/330 (15%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII--HAKRTYRELRLLKHMKH 80 +Y +G G+YG V D++T R AVK L + I +E++LL+ ++H Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH 65 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC---QKLTDDHVQFLIYQILRG 137 +NVI L+DV EE +Y+V + ++ ++ Q++ G Sbjct: 66 KNVIQLVDVLYN----EEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDG 121 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-----DDEMTGYVATRWYRAPE 192 L+Y+HS I+H+D+KP NL + LKI G+A DD + ++ PE Sbjct: 122 LEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPE 181 Query: 193 IMLNWMHYN-QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 I ++ VDIWS G + + TG F G + + I + Sbjct: 182 IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPG------- 234 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311 P DLL+ ML + KR + Q H++F + Sbjct: 235 ------------------------DCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKK 270 Query: 312 HDPDDEPVADPYDQSFESRDLLIDEWKSLT 341 H P + PV P D W+S+T Sbjct: 271 HPPAEAPVPIPPSPD------TKDRWRSMT 294 >5FET-A nrPDB Length = 847 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 77/311 (24%), Positives = 135/311 (43%), Gaps = 44/311 (14%) Query: 10 RQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKL-SRPFQSIIHAKRT 68 R ++ T E+ E + +G G +G+V T +R A+K + R S+ Sbjct: 522 RIKMQDTKVEMHE-LETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNI 580 Query: 69 YRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNN-IVKCQKLTDDH 126 E + H +I L+ R+ ++ N Y +T L+ G +L + I K L+ Sbjct: 581 KLEREITAENDHPFIIRLV------RTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQ 634 Query: 127 VQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATR 186 QF + I+ ++Y+H +I++RDLKP N+ +++ +K++DFG A+ V T Sbjct: 635 AQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTLVGTP 694 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 Y APE++L Y TVDIW++G + E + G F G D DQL Sbjct: 695 HYMAPEVILG-KGYGCTVDIWALGVCLYEFICGPLPF-GNDQEDQL-------------- 738 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITA-----AQ 301 E R+ + P ++ +++L++++L RI Sbjct: 739 ------EIFRDILTGQLTFPDY-------VSDQDSINLMKRLLCRLPQGRIGCSINGFKD 785 Query: 302 ALAHAYFAQYH 312 HA+F ++ Sbjct: 786 IKEHAFFGNFN 796 >4XEY-B nrPDB Length = 408 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 72/310 (23%), Positives = 125/310 (40%), Gaps = 50/310 (16%) Query: 3 QERPTFYRQELNKTIWEVPE-RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 + +PT Y N WE+ +G G YG V K L VAVK L + Sbjct: 105 RNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---ED 161 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKC 119 + + +E ++K +KH N++ LL V T Y++T M G L+ + +C Sbjct: 162 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPF------YIITEFMTYGNLLDYLREC 215 Query: 120 QKLTDDHV--QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-HTD 176 + + V ++ QI ++Y+ + IHRDL N V E+ +K+ DFGL+R T Sbjct: 216 NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTG 275 Query: 177 DEMTGYVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQL 232 D T + ++ + APE + + ++ D+W+ G ++ E+ T G + +PG D Sbjct: 276 DTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY 334 Query: 233 KLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLD 292 +L+ + E G +L+ + Sbjct: 335 ELLEKDYRMERPE------------------------------GCPEKVYELMRACWQWN 364 Query: 293 SDKRITAAQA 302 R + A+ Sbjct: 365 PSDRPSFAEI 374 >2FO0-A nrPDB Length = 495 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 125/310 (40%), Gaps = 50/310 (16%) Query: 3 QERPTFYRQELNKTIWEVPE-RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 + +PT Y N WE+ +G G YG V K L VAVK L + Sbjct: 197 RNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---ED 253 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKC 119 + + +E ++K +KH N++ LL V T Y++T M G L+ + +C Sbjct: 254 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPF------YIITEFMTYGNLLDYLREC 307 Query: 120 QKLTDDHV--QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-HTD 176 + + V ++ QI ++Y+ + IHR+L N V E+ +K+ DFGL+R T Sbjct: 308 NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTG 367 Query: 177 DEMTGYVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQL 232 D T + ++ + APE + + ++ D+W+ G ++ E+ T G + +PG D Sbjct: 368 DTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY 426 Query: 233 KLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLD 292 +L+ + E G +L+ + Sbjct: 427 ELLEKDYRMERPE------------------------------GCPEKVYELMRACWQWN 456 Query: 293 SDKRITAAQA 302 R + A+ Sbjct: 457 PSDRPSFAEI 466 >6ED6-A nrPDB Length = 415 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 72/320 (22%), Positives = 119/320 (37%), Gaps = 42/320 (13%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKH 80 E Y + +G GA+G V + A+K LS+ + + E ++ Sbjct: 88 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 147 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQILRGLK 139 V+ L F R L Y+V M G DL N++ + + +F +++ L Sbjct: 148 PWVVQLFYAFQDDRYL------YMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALD 201 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD----EMTGYVATRWYRAPEIML 195 IHS +IHRD+KP N+ +++ LK+ DFG D+ V T Y +PE++ Sbjct: 202 AIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLK 261 Query: 196 ---NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 Y + D WSVG + E+L G T F + I+ + +I S Sbjct: 262 SQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEI-S 320 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA--Q 310 + A+N I + ++ R + H +F Q Sbjct: 321 KHAKNLICAFLTDREVRLG------------------------RNGVEEIRQHPFFKNDQ 356 Query: 311 YHDPDDEPVADPYDQSFESR 330 +H + A P S Sbjct: 357 WHWDNIRETAAPVVPELSSD 376 >6CQF-A nrPDB Length = 297 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 66/291 (22%), Positives = 121/291 (41%), Gaps = 41/291 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 + Y L +G G YG V A D +G VA+K + +E+ +LK +H Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDD--DVSTLQKEILILKTCRHA 73 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVK-CQKLTDDHVQFLIYQILRGLK 139 N++ + + L ++ G L +I + L++ + ++ ++L+GL Sbjct: 74 NIVAYHGSYLWLQKL------WICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 127 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT---GYVATRWYRAPEI--M 194 Y+HS IHRD+K +N+ +N+ E+++ DFG++ + ++ T ++ APE+ + Sbjct: 128 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAV 187 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 YN+ DIWS+G EL + + L L+ + P K S + Sbjct: 188 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAA 247 Query: 255 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAH 305 N+I+ L KR +A + L+H Sbjct: 248 FHNFIKVT--------------------------LTKSPKKRPSATKMLSH 272 >4WNO-A nrPDB Length = 287 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 76/300 (25%), Positives = 127/300 (42%), Gaps = 50/300 (16%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTG-LRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 + +G GA+ V L VAVK +++ + +E+++LK +KHE Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQT-LLGKEIKILKELKHE 77 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK-LTDDHVQFLIYQILRGLK 139 N++ L D E N VYLV G DL + + + L++D ++ + QI ++ Sbjct: 78 NIVALYDF------QEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMR 131 Query: 140 YIHSADIIHRDLKPSNLAVN---------EDCELKILDFGLARHTDDEM--TGYVATRWY 188 +HS IIHRDLKP N+ ++ +KI DFG AR+ M + Y Sbjct: 132 LLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMY 191 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 APE++++ HY+ D+WS+G I+ + LTG+ F + D LRL L+ Sbjct: 192 MAPEVIMS-QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD-----LRLFYEKNKTLVP 245 Query: 249 KISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 I E++ Q L + + + R+ + H + Sbjct: 246 TIPRETSAPLRQLLLALLQR-----------------------NHKDRMDFDEFFHHPFL 282 >6E9W-A nrPDB Length = 443 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 63/242 (26%), Positives = 101/242 (41%), Gaps = 15/242 (6%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKH 80 E Y+ + +G GA+G V T A+K LS+ + + E ++ Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 161 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQILRGLK 139 V+ L F R L Y+V M G DL N++ + + +F +++ L Sbjct: 162 PWVVQLFYAFQDDRYL------YMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALD 215 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE----MTGYVATRWYRAPEIML 195 IHS IHRD+KP N+ +++ LK+ DFG + E V T Y +PE++ Sbjct: 216 AIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLK 275 Query: 196 ---NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 +Y + D WSVG + E+L G T F + I+ + IS Sbjct: 276 SQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISK 335 Query: 253 ES 254 E+ Sbjct: 336 EA 337 >2H8H-A nrPDB Length = 535 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 78/322 (24%), Positives = 129/322 (40%), Gaps = 55/322 (17%) Query: 11 QELNKTIWEVPERYQNLS-PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTY 69 Q L K WE+P L +G G +G V T RVA+K L + + Sbjct: 255 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPG---TMSPEAFL 310 Query: 70 RELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQK---LTDD 125 +E +++K ++HE ++ L V + +Y+VT M L + +K + L Sbjct: 311 QEAQVMKKLRHEKLVQLYAVVSEE-------PIYIVTEYMSKGSLLDFLKGETGKYLRLP 363 Query: 126 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-EMTGYVA 184 + + QI G+ Y+ + +HRDL+ +N+ V E+ K+ DFGLAR +D E T Sbjct: 364 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 423 Query: 185 TRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVG 240 ++ + APE L + + D+WS G ++ EL T GR +PG + + L + R Sbjct: 424 AKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 482 Query: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300 P DL+ + + ++R T Sbjct: 483 MPCP------------------------------PECPESLHDLMCQCWRKEPEERPTFE 512 Query: 301 QALAHAYFAQYHDPDDEPVADP 322 A F + + EP P Sbjct: 513 YLQA---FLEDYFTSTEPQYQP 531 >4AF3-A nrPDB Length = 292 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 71/290 (24%), Positives = 117/290 (40%), Gaps = 42/290 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR-ELRLLKHMKH 80 + ++ P+G G +G+V A + K+ VA+K L + + R E+ + H+ H Sbjct: 23 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH 82 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGL 138 N++ L + F R +YL+ G + K + ++ ++ L Sbjct: 83 PNILRLYNYFYDRRR------IYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADAL 136 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-EMTGYVATRWYRAPEIMLNW 197 Y H +IHRD+KP NL + ELKI DFG + H T Y PE++ Sbjct: 137 MYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGR 196 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 MH N+ VD+W +G + ELL G F H + + I+++ A Sbjct: 197 MH-NEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPA------------- 242 Query: 258 YIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 A DL+ K+L + +R+ AQ AH + Sbjct: 243 ------------------SVPTGAQDLISKLLRHNPSERLPLAQVSAHPW 274 >6F3F-A nrPDB Length = 455 Score = 220 bits (562), Expect = 5e-58, Method: Composition-based stats. Identities = 78/322 (24%), Positives = 129/322 (40%), Gaps = 55/322 (17%) Query: 11 QELNKTIWEVPERYQNLS-PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTY 69 Q L K WE+P L +G G +G V T RVA+K L + + Sbjct: 175 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPG---TMSPEAFL 230 Query: 70 RELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQK---LTDD 125 +E +++K ++HE ++ L V + +Y+VT M L + +K + L Sbjct: 231 QEAQVMKKLRHEKLVQLYAVVSEE-------PIYIVTEYMNKGSLLDFLKGETGKYLRLP 283 Query: 126 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-EMTGYVA 184 + + QI G+ Y+ + +HRDL+ +N+ V E+ K+ DFGLAR +D E T Sbjct: 284 QLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 343 Query: 185 TRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVG 240 ++ + APE L + + D+WS G ++ EL T GR +PG + + L + R Sbjct: 344 AKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 402 Query: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300 P DL+ + + ++R T Sbjct: 403 MPCP------------------------------PECPESLHDLMCQCWRKEPEERPTFE 432 Query: 301 QALAHAYFAQYHDPDDEPVADP 322 A F + + EP P Sbjct: 433 YLQA---FLEDYFTSTEPQYQP 451 >6QAU-A nrPDB Length = 280 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 75/302 (24%), Positives = 128/302 (42%), Gaps = 50/302 (16%) Query: 23 RYQNLSPVGSGAYGSVCAAFDT-KTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 Y VG GA+ V KT VA+K +++ S +E+++LK ++HE Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQI-LLGKEIKILKELQHE 70 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK-LTDDHVQFLIYQILRGLK 139 N++ L DV E N V+LV G DL + ++ + L++D ++ ++QI ++ Sbjct: 71 NIVALYDV------QELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR 124 Query: 140 YIHSADIIHRDLKPSNLAVN---------EDCELKILDFGLARHTDDEM--TGYVATRWY 188 +HS IIHRDLKP N+ ++ +KI DFG AR+ M + Y Sbjct: 125 ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMY 184 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 APE++++ HY+ D+WS+G ++ + L G+ F D LR+ L+ Sbjct: 185 MAPEVIMS-QHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD-----LRMFYEKNRSLMP 238 Query: 249 KISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 I E++ L + + R+ +H + Sbjct: 239 SIPRETSPYLANLLLGLL-----------------------QRNQKDRMDFEAFFSHPFL 275 Query: 309 AQ 310 Q Sbjct: 276 EQ 277 >5UNP-A nrPDB Length = 369 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 85/352 (24%), Positives = 160/352 (45%), Gaps = 57/352 (16%) Query: 20 VPERYQNLSPVGSGAYGSVCAAF-DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 + ERY+ +S +G G +G V + G RVA+K + + + + E+ +L+ + Sbjct: 32 LQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEK---YKEAARLEINVLEKI 88 Query: 79 K-----HENV-IGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ---KLTDDHVQF 129 ++N+ + + D F + + + L+G + +K V+ Sbjct: 89 NEKDPDNKNLCVQMFDWF------DYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRH 142 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLA-VNEDCE------------------LKILDFG 170 + +Q+ + +K++H + H DLKP N+ VN D E ++++DFG Sbjct: 143 MAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFG 202 Query: 171 LARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHID 230 A + + V+TR YRAPE++L + ++Q D+WS+GCI+ E G TLF D+ + Sbjct: 203 SATFDHEHHSTIVSTRHYRAPEVIL-ELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNRE 261 Query: 231 QLKLILRLVGTPGAELLKKISSES--------------ARNYIQSLTQMPKMNFANVFIG 276 L ++ R++G + +++K + A Y++ + P + Sbjct: 262 HLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCK-PLRRYLTSEAE 320 Query: 277 ANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFE 328 + DL+E ML + KR+T +AL H +FA+ EP +D S + Sbjct: 321 EHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRA---EPPNKLWDSSRD 369 >4C0T-A nrPDB Length = 974 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 76/329 (23%), Positives = 134/329 (40%), Gaps = 59/329 (17%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP-FQSIIHAKRTYRELRLLKHMKHE 81 ++ +G G+Y +V A D TG + AVK L + K E L + + Sbjct: 267 DFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNR 326 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKC-QKLTDDHVQFLIYQILRGLK 139 L V + + ++ + +Y V +L ++K L ++ + QIL +K Sbjct: 327 -----LGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIK 381 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------------MTGYVATRW 187 Y+H +IHRDLKP N+ +++ ++I DFG AR + + +V T Sbjct: 382 YMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAE 441 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247 Y +PE++ N + + D+W+ GCI+ +++ G+ F T+ + I +L Sbjct: 442 YVSPELLEN-KYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKL--------- 491 Query: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 + F+ F DL++K+LVL +R T + H + Sbjct: 492 -------------------QFAFSAGFPTI---IRDLIKKILVLQPSRRATIPEIQKHYF 529 Query: 308 FAQYHDPD-------DEPVADPYDQSFES 329 F D D P PY + +S Sbjct: 530 FQSVDFKDFDSIWLSDPPEIGPYKMTAKS 558 >5LOH-A nrPDB Length = 341 Score = 220 bits (561), Expect = 8e-58, Method: Composition-based stats. Identities = 70/321 (21%), Positives = 121/321 (37%), Gaps = 49/321 (15%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKH 80 E + + P+ GA+G V K G AVK + + + + E L K Sbjct: 36 EEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS 93 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVK-CQKLTDDHVQFLIYQILRGL 138 ++ L SL+ N+VYLV + G D+ +++ ++ I ++ L Sbjct: 94 PFIVHLY------YSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALAL 147 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---------MTGYVATRWYR 189 Y+H IIHRDLKP N+ ++ + +K+ DFGL++ T + + T Y Sbjct: 148 DYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYL 207 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 APE++L H VD W++G + E LTG F + IL+ Sbjct: 208 APELLLGRAH-GPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILK------------ 254 Query: 250 ISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 + + + A +E +L +D KR + H F+ Sbjct: 255 ----------------RDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFS 298 Query: 310 QYHDPDDEPVADPYDQSFESR 330 + + P+ + Sbjct: 299 DVDWENLQHQTMPFIPQPDDE 319 >3FXW-A nrPDB Length = 336 Score = 220 bits (561), Expect = 8e-58, Method: Composition-based stats. Identities = 75/352 (21%), Positives = 135/352 (38%), Gaps = 45/352 (12%) Query: 10 RQELNKTIWEVPERYQN-LSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRT 68 Q + V + YQ +G G G V F +TG + A+K L + + Sbjct: 16 FQGPEPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL-------YDSPKA 68 Query: 69 YRELRLLKHMKH-ENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK---LT 123 +E+ +++ +LDV+ + ++ M G +L + ++ + T Sbjct: 69 RQEVDHHWQASGGPHIVCILDVYENMH--HGKRCLLIIMECMEGGELFSRIQERGDQAFT 126 Query: 124 DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN---EDCELKILDFGLARHTDDE-M 179 + ++ I ++++HS +I HRD+KP NL +D LK+ DFG A+ T + Sbjct: 127 EREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNAL 186 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239 T +Y APE++ Y+++ D+WS+G IM LL G F Sbjct: 187 QTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTG----------- 234 Query: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITA 299 + IS R P ++ V + A L+ +L D +R+T Sbjct: 235 --------QAISPGMKRRIRLGQYGFPNPEWSEV----SEDAKQLIRLLLKTDPTERLTI 282 Query: 300 AQALAHAYFAQ--YHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFV 349 Q + H + Q A + + D + +E S + + Sbjct: 283 TQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYD 334 >4RA4-A nrPDB Length = 355 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 66/321 (20%), Positives = 123/321 (38%), Gaps = 50/321 (15%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSIIHAKRTYRELRLLKHMKHE 81 + L +G G++G V A T A+K L + + T E R+L + Sbjct: 21 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP 80 Query: 82 -NVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLK 139 + L F L +++ ++ G DL +I + K + F +I GL Sbjct: 81 PFLTQLHSCFQTVDRL-----YFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLF 135 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH---TDDEMTGYVATRWYRAPEIMLN 196 ++H II+RDLK N+ ++ + +KI DFG+ + + T Y APEI+ Sbjct: 136 FLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIA- 194 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 256 + Y ++VD W+ G ++ E+L G+ F G D + + I+ + L Sbjct: 195 YQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSL---------- 244 Query: 257 NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITA-----AQALAHAYFAQ- 310 + AV + + ++ KR+ HA+F + Sbjct: 245 ---------------------SKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRI 283 Query: 311 -YHDPDDEPVADPYDQSFESR 330 + ++ + P+ + Sbjct: 284 DWEKLENREIQPPFKPKVSGK 304 >6EII-A nrPDB Length = 352 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 89/320 (27%), Positives = 164/320 (51%), Gaps = 22/320 (6%) Query: 1 MSQERPTFYR-QELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF 59 ++ RP+ Y E + W + YQ + +G G Y V A + + + Sbjct: 38 VNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKI 92 Query: 60 QSIIHAKRTYRELRLLKHMKH-ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK 118 + K+ RE+++L++++ N+I L D+ S + H+ D + Sbjct: 93 LKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVS---RTPALVFEHVNNTDFKQLY- 148 Query: 119 CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR--HT 175 Q LTD ++F +Y+IL+ L Y HS I+HRD+KP N+ ++ E +L+++D+GLA H Sbjct: 149 -QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 207 Query: 176 DDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTL-FPGTDHIDQLKL 234 E VA+R+++ PE+++++ Y+ ++D+WS+GC++A ++ + F G D+ DQL Sbjct: 208 GQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 267 Query: 235 ILRLVGTPGA-ELLKKISSESARNYIQSLTQMPKMNFANVFIGAN-----PLAVDLLEKM 288 I +++GT + + K + E + L + + + N P A+D L+K+ Sbjct: 268 IAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 327 Query: 289 LVLDSDKRITAAQALAHAYF 308 L D R+TA +A+ H YF Sbjct: 328 LRYDHQSRLTAREAMEHPYF 347 >2PVN-A nrPDB Length = 352 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 81/319 (25%), Positives = 150/319 (47%), Gaps = 19/319 (5%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 ++ E W + Y+ + VG G Y V + K + + + + K Sbjct: 38 YWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNE----KCIIKILKPVKKKKI 93 Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 L N++ LLD+ + ++ D + LTD + Sbjct: 94 KREIKILQNLCGGPNIVKLLDIVRDQ---HSKTPSLIFEYVNNTDFKVLY--PTLTDYDI 148 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE-LKILDFGLAR--HTDDEMTGYVA 184 ++ IY++L+ L Y HS I+HRD+KP N+ ++ + L+++D+GLA H E VA Sbjct: 149 RYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVA 208 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTL-FPGTDHIDQLKLILRLVGTPG 243 +R+++ PE++++ Y+ ++D+WS+GC+ A ++ + F G D+ DQL I +++GT G Sbjct: 209 SRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDG 268 Query: 244 -AELLKKISSESARNYIQSLTQMPKMNF-----ANVFIGANPLAVDLLEKMLVLDSDKRI 297 L K E + + + + A+ +P A+D L+K+L D +R+ Sbjct: 269 LNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERL 328 Query: 298 TAAQALAHAYFAQYHDPDD 316 TA +A+ H YF Q ++ Sbjct: 329 TALEAMTHPYFQQVRAAEN 347 >3NYO-A nrPDB Length = 576 Score = 217 bits (553), Expect = 7e-57, Method: Composition-based stats. Identities = 82/350 (23%), Positives = 140/350 (40%), Gaps = 55/350 (15%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR-TYRELRLLKHMKHEN 82 ++ +G G +G VCA TG A KKL + + E ++L+ + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK---LTDDHVQFLIYQILRGL 138 V+ L + E + + LV LM G DL + + F +I GL Sbjct: 246 VVSLAYAY------ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT--DDEMTGYVATRWYRAPEIMLN 196 + +H I++RDLKP N+ +++ ++I D GLA H + G V T Y APE++ N Sbjct: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 256 Y + D W++GC++ E++ G++ F + + + RLV E ++ Sbjct: 360 ER-YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERF------ 412 Query: 257 NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQALAHAYFAQY 311 +P A L ++L D +R+ +A + H F + Sbjct: 413 ---------------------SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 Query: 312 HDP-----DDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQE 356 + EP P Q+ +D+L E S + P DQ+ Sbjct: 452 NFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELE----PTDQD 497 >3PPZ-A nrPDB Length = 309 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 64/297 (21%), Positives = 121/297 (40%), Gaps = 31/297 (10%) Query: 6 PTFYRQE-LNKTIWEVPE-RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII 63 Y Q ++ ++P +G+G++G+V A G VAVK L Sbjct: 19 ENLYFQGAMDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAE 76 Query: 64 HAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK----C 119 RE+ ++K ++H N++ + T +L + +L L ++ Sbjct: 77 RVNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLS-----IVTEYLSRGSLYRLLHKSGAR 131 Query: 120 QKLTDDHVQFLIYQILRGLKYIHSAD--IIHRDLKPSNLAVNEDCELKILDFGLARHTDD 177 ++L + + Y + +G+ Y+H+ + I+HRDLK NL V++ +K+ DFGL+R Sbjct: 132 EQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKAS 191 Query: 178 EM---TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKL 234 T + APE++ + N+ D++S G I+ EL T + + + + Sbjct: 192 TFLSSKSAAGTPEWMAPEVLRD-EPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAA 250 Query: 235 ILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAV--DLLEKML 289 + K E RN + + + + N A DLL ++ Sbjct: 251 VG----------FKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLI 297 >5SYS-A nrPDB Length = 286 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 78/322 (24%), Positives = 128/322 (39%), Gaps = 55/322 (17%) Query: 11 QELNKTIWEVPERYQNLS-PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTY 69 Q L K WE+P L +G G +G T RVA+K L + + Sbjct: 6 QGLAKDAWEIPRESLRLEVKLGQGCFGECWMGTWNGT-TRVAIKTLKPG---TMSPEAFL 61 Query: 70 RELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKC---QKLTDD 125 +E +++K ++HE ++ L V + +Y+VT M L + +K + L Sbjct: 62 QEAQVMKKLRHEKLVQLYAVVSEE-------PIYIVTEYMSKGSLLDFLKGEMGKYLRLP 114 Query: 126 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-EMTGYVA 184 + + QI G+ Y+ + +HRDL+ +N+ V E+ K+ DFGLAR +D E T Sbjct: 115 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 174 Query: 185 TRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVG 240 ++ + APE L + + D+WS G ++ EL T GR +PG + + L + R Sbjct: 175 AKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 233 Query: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300 P DL+ + D ++R T Sbjct: 234 MPCP------------------------------PECPESLHDLMCQCWRKDPEERPTFE 263 Query: 301 QALAHAYFAQYHDPDDEPVADP 322 A F + + EP P Sbjct: 264 YLQA---FLEDYFTSTEPQYQP 282 >5KKR-C nrPDB Length = 395 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 69/307 (22%), Positives = 127/307 (41%), Gaps = 27/307 (8%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 + ++ +S +G+G G V +GL +A K + + I + REL++L Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ-IIRELQVLHECNSP 126 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQILRGLKY 140 ++G F + + H+ G L+ ++K ++ + + + +++GL Y Sbjct: 127 YIVGFYGAFYSDGEIS-----ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 181 Query: 141 I-HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM-TGYVATRWYRAPEIMLNWM 198 + I+HRD+KPSN+ VN E+K+ DFG++ D M +V TR Y +PE + Sbjct: 182 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-T 240 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL------------ 246 HY+ DIWS+G + E+ GR P D + + V AE Sbjct: 241 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 300 Query: 247 ---LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQAL 303 + + + + P + D + K L+ + +R Q + Sbjct: 301 SYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSL--EFQDFVNKCLIKNPAERADLKQLM 358 Query: 304 AHAYFAQ 310 HA+ + Sbjct: 359 VHAFIKR 365 >3TKU-A nrPDB Length = 433 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 71/323 (21%), Positives = 129/323 (39%), Gaps = 48/323 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELR-LLKHMKH 80 E ++ + +G GA+G V T A+K L++ +RE R +L + Sbjct: 90 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 149 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVT-HLMGADLNNIVKC--QKLTDDHVQFLIYQILRG 137 + + L F ++ N +YLV + +G DL ++ KL +D +F I +++ Sbjct: 150 QWITALHYAF------QDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLA 203 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY----VATRWYRAPEI 193 + IH +HRD+KP N+ ++ + +++ DFG +D+ T V T Y +PEI Sbjct: 204 IDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEI 263 Query: 194 ML----NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 + Y D WS+G M E+L G T F ++ I+ Sbjct: 264 LQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN------------ 311 Query: 250 ISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI---TAAQALAHA 306 + F + + A DL+++ L+ ++R+ HA Sbjct: 312 --------------HEERFQFPSHVTDVSEEAKDLIQR-LICSRERRLGQNGIEDFKKHA 356 Query: 307 YFAQYHDPDDEPVADPYDQSFES 329 +F + + + PY S Sbjct: 357 FFEGLNWENIRNLEAPYIPDVSS 379 >3A8W-A nrPDB Length = 345 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 78/358 (21%), Positives = 145/358 (40%), Gaps = 49/358 (13%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP-FQSIIHAKRTYRELRLLKHM-K 79 + + L +G G+Y V KT A+K + + E + + Sbjct: 9 QDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN 68 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGL 138 H ++GL F L +++ ++ G DL ++ + +KL ++H +F +I L Sbjct: 69 HPFLVGLHSCFQTESRL-----FFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLAL 123 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH---TDDEMTGYVATRWYRAPEIML 195 Y+H II+RDLK N+ ++ + +K+ D+G+ + D + + T Y APEI+ Sbjct: 124 NYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILR 183 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 Y +VD W++G +M E++ GR+ F +VG+ S Sbjct: 184 G-EDYGFSVDWWALGVLMFEMMAGRSPF-------------DIVGS---------SDNPD 220 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITA------AQALAHAYFA 309 +N L Q+ + + A +L+ L D +R+ A H +F Sbjct: 221 QNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFR 280 Query: 310 --QYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPP------PLDQEEME 359 + + + V P+ + S + +D + S +E + P +DQ E E Sbjct: 281 NVDWDMMEQKQVVPPFKPNI-SGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFE 337 >6E2O-A nrPDB Length = 295 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 76/290 (26%), Positives = 127/290 (43%), Gaps = 44/290 (15%) Query: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 +G G YG V A D +R+A+K++ P + +++ + E+ L KH+KH+N++ L Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKHLKHKNIVQYLG 86 Query: 89 VFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ----KLTDDHVQFLIYQILRGLKYIHSA 144 F+ ++ F + + G L+ +++ + K + + F QIL GLKY+H Sbjct: 87 SFSENGFIKIF-----MEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDN 141 Query: 145 DIIHRDLKPSNLAVNE-DCELKILDFGLARH---TDDEMTGYVATRWYRAPEIM-LNWMH 199 I+HRD+K N+ +N LKI DFG ++ + + T Y APEI+ Sbjct: 142 QIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRG 201 Query: 200 YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYI 259 Y + DIWS+GC + E+ TG+ F +G P A + K + Sbjct: 202 YGKAADIWSLGCTIIEMATGKPPFY-------------ELGEPQAAMFK----------V 238 Query: 260 QSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 P+ + + A + K D DKR A L + Sbjct: 239 GMFKVHPE-----IPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLK 283 >6NPU-A nrPDB Length = 298 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 71/308 (23%), Positives = 122/308 (39%), Gaps = 51/308 (16%) Query: 6 PTFYRQE-LNKTIWEVPE-RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII 63 Y Q N WE+ +G G YG V K L VAVK L + + Sbjct: 8 ENLYFQGSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTM 64 Query: 64 HAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQK 121 + +E ++K +KH N++ LL V T Y++T M G L+ + +C + Sbjct: 65 EVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPF------YIITEFMTYGNLLDYLRECNR 118 Query: 122 LTDDHV--QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-HTDDE 178 + V ++ QI ++Y+ + IHRDL N V E+ +K+ DFGL+R T D Sbjct: 119 QEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT 178 Query: 179 MTGYVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKL 234 T + ++ + APE + + ++ D+W+ G ++ E+ T G + +PG D +L Sbjct: 179 YTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYEL 237 Query: 235 ILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSD 294 + + E G +L+ + Sbjct: 238 LEKDYRMERPE------------------------------GCPEKVYELMRACWQWNPS 267 Query: 295 KRITAAQA 302 R + A+ Sbjct: 268 DRPSFAEI 275 >6BDL-A nrPDB Length = 347 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 125/301 (41%), Gaps = 47/301 (15%) Query: 23 RYQNLSPVGSGAYGSVCAAFDT-KTGLRVAVKKLSRPFQ-SIIHAKRTYRELRLLKHMKH 80 + + +G G +G V + A+K L + + E ++++ Sbjct: 35 DFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHS 94 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTH-LMGADLNNIVK-CQKLTDDHVQFLIYQILRGL 138 + ++ L R+ ++ +Y++ +G +L I++ D +F ++ Sbjct: 95 DFIVRLY------RTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAF 148 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT--DDEMTGYVATRWYRAPEIMLN 196 Y+HS II+RDLKP NL ++ K++DFG A+ + + T Y APEI+LN Sbjct: 149 AYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILN 208 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 256 H + + D WS+G +M ELLTG F G D + +ILR G E KKI+ +A Sbjct: 209 KGH-DISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILR--GIDMIEFPKKIAKNAA- 264 Query: 257 NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQALAHAYFAQY 311 +L++K+ + +R+ H +F + Sbjct: 265 --------------------------NLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGF 298 Query: 312 H 312 + Sbjct: 299 N 299 >2XYN-A nrPDB Length = 292 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 77/321 (23%), Positives = 130/321 (40%), Gaps = 55/321 (17%) Query: 4 ERPTFYRQELNKTIWEVPE-RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSI 62 Y Q ++K WE+ +G G YG V K L VAVK L + Sbjct: 15 GTENLYFQSMDK--WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK---EDT 69 Query: 63 IHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQ 120 + + +E ++K +KH N++ LL V T Y+VT M G L+ + +C Sbjct: 70 MEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPF------YIVTEYMPYGNLLDYLRECN 123 Query: 121 K--LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-HTDD 177 + +T + ++ QI ++Y+ + IHRDL N V E+ +K+ DFGL+R T D Sbjct: 124 REEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGD 183 Query: 178 EMTGYVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLK 233 T + ++ + APE + + ++ D+W+ G ++ E+ T G + +PG D Sbjct: 184 TYTAHAGAKFPIKWTAPESLA-YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYD 242 Query: 234 LILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDS 293 L+ + E G P +L+ Sbjct: 243 LLEKGYRMEQPE------------------------------GCPPKVYELMRACWKWSP 272 Query: 294 DKRITAAQALAH-AYFAQYHD 313 R + A+ H A+ +HD Sbjct: 273 ADRPSFAE--THQAFETMFHD 291 >3EQC-A nrPDB Length = 360 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 130/305 (42%), Gaps = 23/305 (7%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 + ++ +S +G+G G V +GL +A K + + I + REL++L Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ-IIRELQVLHECNSP 91 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQILRGLKY 140 ++G F + + H+ G L+ ++K ++ + + + +++GL Y Sbjct: 92 YIVGFYGAFYSDGEISIC-----MEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 146 Query: 141 I-HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM-TGYVATRWYRAPEIMLNWM 198 + I+HRD+KPSN+ VN E+K+ DFG++ D M +V TR Y +PE + Sbjct: 147 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-T 205 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQ-LKLILRLVGTPGAELLKKISSESARN 257 HY+ DIWS+G + E+ GR P D + L ++ G + + N Sbjct: 206 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLN 265 Query: 258 YIQSLTQMPKMNFANVFIGANP------------LAVDLLEKMLVLDSDKRITAAQALAH 305 ++ P F + N D + K L+ + +R Q + H Sbjct: 266 KFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVH 325 Query: 306 AYFAQ 310 A+ + Sbjct: 326 AFIKR 330 >4GS6-A nrPDB Length = 315 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 77/319 (24%), Positives = 124/319 (38%), Gaps = 57/319 (17%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 + + VG GA+G VC A VA+K++ +S K ELR L + H Sbjct: 9 KEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQI----ESESERKAFIVELRQLSRVNHP 62 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKC----QKLTDDHVQFLIYQILR 136 N++ L N V LV G L N++ T H Q + Sbjct: 63 NIVKLYGACL--------NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQ 114 Query: 137 GLKYIHSAD---IIHRDLKPSNLAVNEDCEL-KILDFGLARHTDDEMTGYVATRWYRAPE 192 G+ Y+HS +IHRDLKP NL + + KI DFG A MT + + APE Sbjct: 115 GVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPE 174 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 + +Y++ D++S G I+ E++T R F +G P ++ + + Sbjct: 175 VFEGS-NYSEKCDVFSWGIILWEVITRRKPF-------------DEIGGPAFRIMWAVHN 220 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQ---ALAHAYFA 309 + I++L + + L+ + D +R + + + H Sbjct: 221 GTRPPLIKNLPKPIE---------------SLMTRCWSKDPSQRPSMEEIVKIMTH--LM 263 Query: 310 QYHDPDDEPVADPYDQSFE 328 +Y DEP+ P S Sbjct: 264 RYFPGADEPLQYPCQHSLP 282 >2BRG-A nrPDB Length = 297 Score = 214 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 74/296 (25%), Positives = 125/296 (42%), Gaps = 42/296 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E + + +G GAYG V A + T VAVK + +++ + +E+ + K + HE Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK-RAVDCPENIKKEICINKMLNHE 65 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ-KLTDDHVQFLIYQILRGLK 139 NV+ E N YL G +L + ++ + + Q +Q++ G+ Sbjct: 66 NVVKFYG------HRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVV 119 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLA---RHTDDE--MTGYVATRWYRAPEIM 194 Y+H I HRD+KP NL ++E LKI DFGLA R+ + E + T Y APE++ Sbjct: 120 YLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELL 179 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 + + VD+WS G ++ +L G + DQ P + + Sbjct: 180 KRREFHAEPVDVWSCGIVLTAMLAGELPW------DQ----------PSDSCQEYSDWKE 223 Query: 255 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 + Y+ ++ A LL K+LV + RIT ++ + Sbjct: 224 KKTYLNPWKKIDSAPLA------------LLHKILVENPSARITIPDIKKDRWYNK 267 >4AW2-A nrPDB Length = 437 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 65/323 (20%), Positives = 123/323 (38%), Gaps = 48/323 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELR-LLKHMKH 80 E ++ L +G GA+G V A+K L++ +RE R +L + Sbjct: 74 EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDS 133 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVT-HLMGADLNNIVKC--QKLTDDHVQFLIYQILRG 137 + + L F ++ N++YLV + +G DL ++ +L ++ +F + +++ Sbjct: 134 KWITTLHYAF------QDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIA 187 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY----VATRWYRAPEI 193 + +H +HRD+KP N+ ++ + +++ DFG ++ T V T Y +PEI Sbjct: 188 IDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEI 247 Query: 194 ML----NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 + Y D WS+G M E+L G T F ++ I+ Sbjct: 248 LQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN------------ 295 Query: 250 ISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI---TAAQALAHA 306 + F + A DL+ + L+ + R+ H Sbjct: 296 --------------HKERFQFPTQVTDVSENAKDLIRR-LICSREHRLGQNGIEDFKKHP 340 Query: 307 YFAQYHDPDDEPVADPYDQSFES 329 +F+ + PY S Sbjct: 341 FFSGIDWDNIRNCEAPYIPEVSS 363 >3VN9-A nrPDB Length = 340 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 75/311 (24%), Positives = 131/311 (42%), Gaps = 48/311 (15%) Query: 12 ELNKTIWEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR 70 + +EV + + + +G GAYG V +G +AVK++ S KR Sbjct: 40 SIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ-EQKRLLM 98 Query: 71 ELRL-LKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-----QKLTD 124 +L + ++ + + L DV++ LM L+ K Q + + Sbjct: 99 DLDISMRTVDCPFTVTFYGA------LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPE 152 Query: 125 DHVQFLIYQILRGLKYIHSA-DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV 183 D + + I++ L+++HS +IHRD+KPSN+ +N ++K+ DFG++ + D + + Sbjct: 153 DILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTI 212 Query: 184 --ATRWYRAPEIM---LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL 238 + Y APE + LN Y+ DIWS+G M EL R + Sbjct: 213 DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY-------------DS 259 Query: 239 VGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT 298 GTP +L + + S Q+P F + VD + L +S +R T Sbjct: 260 WGTPFQQLKQVVEEPS--------PQLPADKF-------SAEFVDFTSQCLKKNSKERPT 304 Query: 299 AAQALAHAYFA 309 + + H +F Sbjct: 305 YPELMQHPFFT 315 >4IAN-A nrPDB Length = 358 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 93/341 (27%), Positives = 152/341 (44%), Gaps = 43/341 (12%) Query: 6 PTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDT-KTGLRVAVKKLSRPFQSIIH 64 +YR + + + +RY G G + +V A D + VAVK + Sbjct: 17 EGYYRVNIGEV---LDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQ-- 71 Query: 65 AKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK--- 121 K +EL LK + + R + LV + +L ++K Sbjct: 72 -KTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDV 130 Query: 122 -LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL-KILDFGLARHT-DDE 178 L V+ Q+ LK + +I+H D+KP N+ VNE + K+ DFG A H D++ Sbjct: 131 GLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND 190 Query: 179 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL 238 +T Y+ +R+YRAPEI++ Y+ +D+WSVGC + EL TG+ LFPG + LKL + L Sbjct: 191 ITPYLVSRFYRAPEIIIG-KSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDL 249 Query: 239 VGTPGAELLKK------------------ISSESARNYIQSLTQM-PKMNFANVFIGANP 279 G ++++K + + R + ++ + P + IG Sbjct: 250 KGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQR 309 Query: 280 L----------AVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 L DLL+++L+LD KRI+ QAL HA+ + Sbjct: 310 LPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 350 >3PFQ-A nrPDB Length = 674 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 72/350 (20%), Positives = 130/350 (37%), Gaps = 57/350 (16%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSIIHAKRTYRELRLLKHMKHE 81 + L +G G++G V + T AVK L + + T E R+L Sbjct: 342 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 401 Query: 82 -NVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLK 139 + L F L +++ ++ G DL +I + + + H F +I GL Sbjct: 402 PFLTQLHSCFQTMDRL-----YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 456 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT---DDEMTGYVATRWYRAPEIMLN 196 ++ S II+RDLK N+ ++ + +KI DFG+ + + T Y APEI+ Sbjct: 457 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA- 515 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 256 + Y ++VD W+ G ++ E+L G+ F G D + + I+ + Sbjct: 516 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSM---------- 565 Query: 257 NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITA-----AQALAHAYFA-- 309 + AV + + ++ KR+ HA+F Sbjct: 566 ---------------------SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 604 Query: 310 QYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEME 359 + + + + PY R+ +D + PP L + E Sbjct: 605 DWEKLERKEIQPPYKPKASGRNAEN-------FDRFFTRHPPVLTPPDQE 647 >1NY3-A nrPDB Length = 400 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 71/330 (21%), Positives = 133/330 (40%), Gaps = 51/330 (15%) Query: 20 VPERYQNLS-PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 + + Y+ S +G G G V F+ +T + A+K L + RE+ L Sbjct: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRA 111 Query: 79 -KHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK---LTDDHVQFLIYQ 133 + +++ ++DV+ + + +V + G +L + ++ + T+ ++ Sbjct: 112 SQCPHIVRIVDVYENLYAGR--KCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNE---DCELKILDFGLARHT--DDEMTGYVATRWY 188 I ++Y+HS +I HRD+KP NL + LK+ DFG A+ T + +T T +Y Sbjct: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYY 229 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 APE++ Y+++ D+WS+G IM LL G F + Sbjct: 230 VAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL------------------- 269 Query: 249 KISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 IS + P ++ V + L+ +L + +R+T + + H + Sbjct: 270 AISPGMKTRIRMGQYEFPNPEWSEV----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 Query: 309 AQYHDPDDEPVADPYDQSFESRDLLIDEWK 338 Q P SR L D+ + Sbjct: 326 MQ-------STKVPQTPLHTSRVLKEDKER 348 >4FR4-A nrPDB Length = 384 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 71/319 (22%), Positives = 133/319 (41%), Gaps = 50/319 (15%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR-TYRELRLLKHMKH 80 + ++ L +G G++G VC T A+K +++ + R ++EL++++ ++H Sbjct: 15 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEH 74 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ-KLTDDHVQFLIYQILRGLK 139 ++ L F E + +V L+G DL ++ ++ V+ I +++ L Sbjct: 75 PFLVNLWYSFQD-----EEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALD 129 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT--DDEMTGYVATRWYRAPEIMLNW 197 Y+ + IIHRD+KP N+ ++E + I DF +A + ++T T+ Y APE+ + Sbjct: 130 YLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSR 189 Query: 198 M--HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 Y+ VD WS+G ELL GR + S E Sbjct: 190 KGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTS--------------------SKEIV 229 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPD 315 + ++ P + V LL+K+L + D+R F+Q D Sbjct: 230 HTFETTVVTYPS--------AWSQEMVSLLKKLLEPNPDQR-----------FSQLSDVQ 270 Query: 316 DEPVADPYDQSFESRDLLI 334 + P + + + LI Sbjct: 271 NFPYMNDINWDAVFQKRLI 289 >4AN9-A nrPDB Length = 301 Score = 211 bits (538), Expect = 4e-55, Method: Composition-based stats. Identities = 69/292 (23%), Positives = 126/292 (43%), Gaps = 39/292 (13%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 + ++ +S +G+G G V +GL +A K + + I + REL++L Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ-IIRELQVLHECNSP 67 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQILRGLKY 140 ++G F + + H+ G L+ ++K ++ + + + +++GL Y Sbjct: 68 YIVGFYGAFYSDGEISIC-----MEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 122 Query: 141 I-HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM-TGYVATRWYRAPEIMLNWM 198 + I+HRD+KPSN+ VN E+K+ DFG++ DEM +V TR Y +PE + Sbjct: 123 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQG-T 181 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY 258 HY+ DIWS+G + E+ GR P + L I+ Sbjct: 182 HYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVN--------------------- 220 Query: 259 IQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 + ++P F + D + K L+ + +R Q + HA+ + Sbjct: 221 -EPPPKLPSAVF-------SLEFQDFVNKCLIKNPAERADLKQLMVHAFIKR 264 >2OZA-A nrPDB Length = 356 Score = 210 bits (536), Expect = 5e-55, Method: Composition-based stats. Identities = 71/330 (21%), Positives = 133/330 (40%), Gaps = 51/330 (15%) Query: 20 VPERYQNLS-PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 + + Y+ S +G G G V F+ +T + A+K L + RE+ L Sbjct: 15 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRA 67 Query: 79 -KHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK---LTDDHVQFLIYQ 133 + +++ ++DV+ + + +V + G +L + ++ + T+ ++ Sbjct: 68 SQCPHIVRIVDVYENLYAGR--KCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 125 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNE---DCELKILDFGLARHT--DDEMTGYVATRWY 188 I ++Y+HS +I HRD+KP NL + LK+ DFG A+ T + +T T +Y Sbjct: 126 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYY 185 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 APE++ Y+++ D+WS+G IM LL G F + Sbjct: 186 VAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL------------------- 225 Query: 249 KISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 IS + P ++ V + L+ +L + +R+T + + H + Sbjct: 226 AISPGMKTRIRMGQYEFPNPEWSEV----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 281 Query: 309 AQYHDPDDEPVADPYDQSFESRDLLIDEWK 338 Q P SR L D+ + Sbjct: 282 MQ-------STKVPQTPLHTSRVLKEDKER 304 >3KA0-A nrPDB Length = 320 Score = 210 bits (536), Expect = 6e-55, Method: Composition-based stats. Identities = 71/330 (21%), Positives = 133/330 (40%), Gaps = 51/330 (15%) Query: 20 VPERYQNLS-PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 + + Y+ S +G G G V F+ +T + A+K L + RE+ L Sbjct: 13 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRA 65 Query: 79 -KHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK---LTDDHVQFLIYQ 133 + +++ ++DV+ + + +V + G +L + ++ + T+ ++ Sbjct: 66 SQCPHIVRIVDVYENLYAGR--KCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 123 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNE---DCELKILDFGLARHT--DDEMTGYVATRWY 188 I ++Y+HS +I HRD+KP NL + LK+ DFG A+ T + +T T +Y Sbjct: 124 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYY 183 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 APE++ Y+++ D+WS+G IM LL G F + Sbjct: 184 VAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL------------------- 223 Query: 249 KISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 IS + P ++ V + L+ +L + +R+T + + H + Sbjct: 224 AISPGMKTRIRMGQYEFPNPEWSEV----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 279 Query: 309 AQYHDPDDEPVADPYDQSFESRDLLIDEWK 338 Q P SR L D+ + Sbjct: 280 MQ-------STKVPQTPLHTSRVLKEDKER 302 >3FME-A nrPDB Length = 290 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 73/300 (24%), Positives = 128/300 (42%), Gaps = 47/300 (15%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRL-LKHMKH 80 + + + +G GAYG V +G +AVK++ S KR +L + ++ + Sbjct: 7 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ-EQKRLLMDLDISMRTVDC 65 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-----QKLTDDHVQFLIYQIL 135 + L DV++ LM L+ K Q + +D + + I+ Sbjct: 66 PFTVTFYGA------LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 119 Query: 136 RGLKYIHSA-DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV--ATRWYRAPE 192 + L+++HS +IHRD+KPSN+ +N ++K+ DFG++ + D++ + + Y APE Sbjct: 120 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPE 179 Query: 193 IM---LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 + LN Y+ DIWS+G M EL R + GTP +L + Sbjct: 180 RINPELNQKGYSVKSDIWSLGITMIELAILRFPY-------------DSWGTPFQQLKQV 226 Query: 250 ISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 + S Q+P F + VD + L +S +R T + + H +F Sbjct: 227 VEEPS--------PQLPADKF-------SAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 271 >5O2B-A nrPDB Length = 285 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 69/288 (23%), Positives = 126/288 (43%), Gaps = 38/288 (13%) Query: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 +G GA+ +V DT+T + VA +L + +R E +LK ++H N++ D Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 82 Query: 89 VFTPARSLEEFNDVYLVTHLM-GADLNNIVKC-QKLTDDHVQFLIYQILRGLKYIHSA-- 144 + L+ + LVT LM L +K + + ++ QIL+GL+++H+ Sbjct: 83 SWES--ILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 140 Query: 145 DIIHRDLKPSNLAVN-EDCELKILDFGLARHTDDEM-TGYVATRWYRAPEIMLNWMHYNQ 202 IIHRDLK N+ + +KI D GLA + T + APE+ HY++ Sbjct: 141 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMY--EEHYDE 198 Query: 203 TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSL 262 +VD+++ G M E+ T + + Q+ Y + Sbjct: 199 SVDVYAFGMCMLEMATSEYPYSECQNAAQI-------------------------YRKVT 233 Query: 263 TQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 + + +F V +P +++E + + +R++ L HA+FA+ Sbjct: 234 SGIKPASFNKV---TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 >2DQ7-X nrPDB Length = 283 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 75/318 (23%), Positives = 131/318 (41%), Gaps = 55/318 (17%) Query: 15 KTIWEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELR 73 K +WE+P E Q + +G+G +G V +VA+K L + + E + Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPG---TMSPESFLEEAQ 56 Query: 74 LLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVK---CQKLTDDHVQF 129 ++K +KH+ ++ L V + +Y+VT M L + +K + L ++ Sbjct: 57 IMKKLKHDKLVQLYAVVSEE-------PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVD 109 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-EMTGYVATRW- 187 + Q+ G+ YI + IHRDL+ +N+ V KI DFGLAR +D E T ++ Sbjct: 110 MAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFP 169 Query: 188 --YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGA 244 + APE L + + D+WS G ++ EL+T GR +PG ++ + L+ + R P Sbjct: 170 IKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCP 228 Query: 245 ELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304 + +L+ D ++R T + Sbjct: 229 QDCPI------------------------------SLHELMIHCWKKDPEERPTFEYLQS 258 Query: 305 HAYFAQYHDPDDEPVADP 322 F + + EP P Sbjct: 259 ---FLEDYFTATEPQYQP 273 >6CCF-A nrPDB Length = 290 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 67/318 (21%), Positives = 128/318 (40%), Gaps = 63/318 (19%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR------------------------P 58 +Y+ S +G GAYG V A++ A+K LS+ P Sbjct: 6 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGP 65 Query: 59 FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV 117 + ++ +R Y+E+ +LK + H NV+ L++V +++YLV L+ + + Sbjct: 66 AKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAE----DNLYLVFDLLRKGPVMEVP 121 Query: 118 KCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-- 175 + +++ + + ++ GL+Y+H I+HRD+KPSNL + +D +KI DFG++ Sbjct: 122 CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEG 181 Query: 176 -DDEMTGYVATRWYRAPEIM--LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQL 232 D +++ T + APE + + +D+W+ G + + G+ F + Sbjct: 182 NDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALH 241 Query: 233 KLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLD 292 + I E + DL+ KML + Sbjct: 242 RKIKNEPVVFPEE-----------------------------PEISEELKDLILKMLDKN 272 Query: 293 SDKRITAAQALAHAYFAQ 310 + RI H + + Sbjct: 273 PETRIGVPDIKLHPWVTK 290 >1S9I-A nrPDB Length = 354 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 75/310 (24%), Positives = 130/310 (41%), Gaps = 29/310 (9%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 + ++ +S +G+G G V +GL +A K + + I + REL++L Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQ-IIRELQVLHECNSP 74 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK-CQKLTDDHVQFLIYQILRGLKY 140 ++G F + + H+ G L+ ++K +++ ++ + + +LRGL Y Sbjct: 75 YIVGFYGAFYSDGEISIC-----MEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAY 129 Query: 141 I-HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM-TGYVATRWYRAPEIMLNWM 198 + I+HRD+KPSN+ VN E+K+ DFG++ D M +V TR Y APE + Sbjct: 130 LREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQG-T 188 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLK---------- 248 HY+ DIWS+G + EL GR P D + L+ I G E Sbjct: 189 HYSVQSDIWSMGLSLVELAVGRYPIPPPDAKE-LEAIFGRPVVDGEEGEPHSISPRPRPP 247 Query: 249 -------KISSESARNYIQSLTQMPKMNFANVFIGA-NPLAVDLLEKMLVLDSDKRITAA 300 + S A + L + + G P + + K L+ + +R Sbjct: 248 GRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLK 307 Query: 301 QALAHAYFAQ 310 H + + Sbjct: 308 MLTNHTFIKR 317 >2I0E-A nrPDB Length = 353 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 72/350 (20%), Positives = 130/350 (37%), Gaps = 57/350 (16%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSIIHAKRTYRELRLLKHMKHE 81 + L +G G++G V + T AVK L + + T E R+L Sbjct: 21 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 80 Query: 82 -NVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLK 139 + L F L +++ ++ G DL +I + + + H F +I GL Sbjct: 81 PFLTQLHSCFQTMDRL-----YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 135 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT---DDEMTGYVATRWYRAPEIMLN 196 ++ S II+RDLK N+ ++ + +KI DFG+ + + T Y APEI+ Sbjct: 136 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA- 194 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 256 + Y ++VD W+ G ++ E+L G+ F G D + + I+ + Sbjct: 195 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSM---------- 244 Query: 257 NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITA-----AQALAHAYFA-- 309 + AV + + ++ KR+ HA+F Sbjct: 245 ---------------------SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 283 Query: 310 QYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEME 359 + + + + PY R+ +D + PP L + E Sbjct: 284 DWEKLERKEIQPPYKPKACGRNAEN-------FDRFFTRHPPVLTPPDQE 326 >4TNB-A nrPDB Length = 590 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 66/300 (22%), Positives = 123/300 (41%), Gaps = 44/300 (14%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR-TYRELRLLKHMKHEN 82 ++ +G G +G VCA TG A K+L + + E ++L+ + + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC---QKLTDDHVQFLIYQILRGLK 139 V+ L + +L ++T + G DL + ++ F +IL GL+ Sbjct: 246 VVNLAYAYETKDAL-----CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT--DDEMTGYVATRWYRAPEIMLNW 197 +H + ++RDLKP N+ +++ ++I D GLA D + G V T Y APE++ N Sbjct: 301 DLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL-NN 359 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 Y + D W +GC++ E++ G++ F G + + + R V K Sbjct: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKF------- 412 Query: 258 YIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYFAQYH 312 + A + + +L D+ +R+ AA+ H +F + Sbjct: 413 --------------------SEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMN 452 >5O2C-A nrPDB Length = 380 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 69/288 (23%), Positives = 126/288 (43%), Gaps = 38/288 (13%) Query: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 +G GA+ +V DT+T + VA +L + +R E +LK ++H N++ D Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 91 Query: 89 VFTPARSLEEFNDVYLVTHLM-GADLNNIVKC-QKLTDDHVQFLIYQILRGLKYIHSA-- 144 + L+ + LVT LM L +K + + ++ QIL+GL+++H+ Sbjct: 92 SWES--ILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 149 Query: 145 DIIHRDLKPSNLAVN-EDCELKILDFGLARHTDDEM-TGYVATRWYRAPEIMLNWMHYNQ 202 IIHRDLK N+ + +KI D GLA + T + APE+ HY++ Sbjct: 150 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMY--EEHYDE 207 Query: 203 TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSL 262 +VD+++ G M E+ T + + Q+ Y + Sbjct: 208 SVDVYAFGMCMLEMATSEYPYSECQNAAQI-------------------------YRKVT 242 Query: 263 TQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 + + +F V +P +++E + + +R++ L HA+FA+ Sbjct: 243 SGIKPASFNKV---TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 287 >5VO2-A nrPDB Length = 300 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 83/329 (25%), Positives = 131/329 (39%), Gaps = 55/329 (16%) Query: 14 NKTIWEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYREL 72 ++ +WEVP E +L VGSGA G+V G VAVKK+ ++ + Sbjct: 3 SEDLWEVPFEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD---------I 51 Query: 73 RLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLI 131 + L+ +KH N+I V T A L+ L +++ + +T + Sbjct: 52 KHLRKLKHPNIITFKGVCTQAPCY-----CILMEFCAQGQLYEVLRAGRPVTPSLLVDWS 106 Query: 132 YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT--GYVATRWYR 189 I G+ Y+H IIHRDLK N+ + D +KI DFG ++ D+ T + T + Sbjct: 107 MGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWM 166 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 APE++ N ++ VDIWS G ++ ELLTG + D I+ VG+ L Sbjct: 167 APEVIRN-EPVSEKVDIWSFGVVLWELLTGEIPYKDVDS----SAIIWGVGSNSLHLP-- 219 Query: 250 ISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 V LL + R + Q L H Sbjct: 220 -----------------------VPSSCPDGFKILLRQCWNSKPRNRPSFRQILLH---- 252 Query: 310 QYHDPDDEPVADPYDQSFESRDLLIDEWK 338 + ++ P + F+S+ +E K Sbjct: 253 -LDIASADVLSTPQETYFKSQAEWREEVK 280 >6GQK-A nrPDB Length = 328 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 77/326 (23%), Positives = 126/326 (38%), Gaps = 68/326 (20%) Query: 11 QELNKTIWEVPE-RYQNLSPVGSGAYGSVCAA-----FDTKTGLRVAVKKLSRPFQSIIH 64 Q WE P R +G+GA+G V A + + VAVK L +P Sbjct: 29 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKML-KPSAHSTE 87 Query: 65 AKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-- 121 + EL++L ++ HEN++ LL T + + + DL N ++ ++ Sbjct: 88 REALMSELKVLSYLGNHENIVNLLGACTHGGP-----TLVITEYCCYGDLLNFLRRKRDE 142 Query: 122 ---------------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKI 166 LT +H+ YQ+ +G+ ++ S + IHRDL N+ + KI Sbjct: 143 FVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKI 202 Query: 167 LDFGLARHTD------DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-G 219 DFGLAR D+ + +W APE + N + Y D+WS G + EL + G Sbjct: 203 CDFGLARDIKNDSNYVDKGNARLPVKW-MAPESIFNSV-YTFESDVWSYGIFLWELFSLG 260 Query: 220 RTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANP 279 + +PG + +++ E + S E A Sbjct: 261 SSPYPGMPVDSKFYKMIK-------EGFRMSSPEYAPA---------------------- 291 Query: 280 LAVDLLEKMLVLDSDKRITAAQALAH 305 D+++ D DKR T Q + Sbjct: 292 EMYDIMKTCWDADPDKRPTFKQIVQD 317 >4E93-A nrPDB Length = 377 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 70/305 (22%), Positives = 116/305 (38%), Gaps = 51/305 (16%) Query: 13 LNKTIWEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRE 71 + K W + E +G G +G V + VAVK + AK +E Sbjct: 104 VPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK-FLQE 162 Query: 72 LRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ--KLTDDHVQ 128 R+LK H N++ L+ V T + +Y+V L+ G D ++ + +L + Sbjct: 163 ARILKQYSHPNIVRLIGVCTQKQP------IYIVMELVQGGDFLTFLRTEGARLRVKTLL 216 Query: 129 FLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW- 187 ++ G++Y+ S IHRDL N V E LKI DFG++R D + Sbjct: 217 QMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQ 276 Query: 188 ----YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTP 242 + APE + N+ Y+ D+WS G ++ E + G + +P + + + + P Sbjct: 277 VPVKWTAPEAL-NYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP 335 Query: 243 GAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI---TA 299 EL VF L+E+ + +R T Sbjct: 336 CPELCP----------------------DAVFR--------LMEQCWAYEPGQRPSFSTI 365 Query: 300 AQALA 304 Q L Sbjct: 366 YQELQ 370 >2WQN-A nrPDB Length = 310 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 72/290 (24%), Positives = 120/290 (41%), Gaps = 32/290 (11%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHE 81 ++ +G G + V A G+ VA+KK+ +E+ LLK + H Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQK-----LTDDHVQFLIYQIL 135 NVI F E N++ +V L DL+ ++K K + + V Q+ Sbjct: 93 NVIKYYASFI------EDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLC 146 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT---GYVATRWYRAPE 192 L+++HS ++HRD+KP+N+ + +K+ D GL R + T V T +Y +PE Sbjct: 147 SALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPE 206 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 + + YN DIWS+GC++ E+ ++ F G D ++ L ++ L S Sbjct: 207 RI-HENGYNFKSDIWSLGCLLYEMAALQSPFYG-DKMNLYSLCKKIEQCDYPPLPSDHYS 264 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQA 302 E R + +V V D KR+ A A Sbjct: 265 EELRQLVNMCINPDPEKRPDVTY--------------VYDVAKRMHACTA 300 >2VD5-A nrPDB Length = 412 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 65/321 (20%), Positives = 119/321 (37%), Gaps = 44/321 (13%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELR-LLKHMKH 80 + ++ L +G GA+ V +TG A+K +++ +RE R +L + Sbjct: 61 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 120 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHL-MGADLNNIVKC--QKLTDDHVQFLIYQILRG 137 + L F ++ N +YLV +G DL ++ +++ + +F + +I+ Sbjct: 121 RWITQLHFAF------QDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMA 174 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY----VATRWYRAPEI 193 + +H +HRD+KP N+ ++ +++ DFG + T V T Y +PEI Sbjct: 175 IDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEI 234 Query: 194 ML------NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247 + Y D W++G E+ G+T F + I+ L+ Sbjct: 235 LQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLV 294 Query: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 + E AR++IQ L P+ R A H + Sbjct: 295 DEGVPEEARDFIQRLLCPPETRLG------------------------RGGAGDFRTHPF 330 Query: 308 FAQYHDPDDEPVADPYDQSFE 328 F P+ FE Sbjct: 331 FFGLDWDGLRDSVPPFTPDFE 351 >4EBW-A nrPDB Length = 304 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 65/308 (21%), Positives = 114/308 (37%), Gaps = 56/308 (18%) Query: 6 PTFYRQELNKTI---WEVP-ERYQNLSPVGSGAYGSVCAAFD---TKTGLRVAVKKLSRP 58 Y Q + +E+ ER + +G G +G V L VA+K + Sbjct: 18 ENLYFQGAMGSSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTC-KN 76 Query: 59 FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIV 117 S ++ +E ++ H +++ L+ V T N V+++ L +L + + Sbjct: 77 CTSDSVREKFLQEALTMRQFDHPHIVKLIGVITE-------NPVWIIMELCTLGELRSFL 129 Query: 118 KCQKLTDDHVQF--LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT 175 + +K + D YQ+ L Y+ S +HRD+ N+ V+ + +K+ DFGL+R+ Sbjct: 130 QVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM 189 Query: 176 DDEM-----TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHI 229 +D G + +W APE + N+ + D+W G M E+L G F G + Sbjct: 190 EDSTYYKASKGKLPIKW-MAPESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNN 247 Query: 230 DQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKML 289 D + I P P L+ K Sbjct: 248 DVIGRIENGERLPMP------------------------------PNCPPTLYSLMTKCW 277 Query: 290 VLDSDKRI 297 D +R Sbjct: 278 AYDPSRRP 285 >4CRS-A nrPDB Length = 341 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 76/380 (20%), Positives = 144/380 (37%), Gaps = 73/380 (19%) Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR--- 57 MSQ+R F Q ++ + + G +G V A T A+K L + Sbjct: 2 MSQQRFQFNLQ-----------DFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDI 50 Query: 58 ----PFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADL 113 S++ KR + + ++H ++ L F + +++ + G DL Sbjct: 51 VARDEVDSLMCEKRIFETVN---SVRHPFLVNLFACFQTKEHV-----CFVMEYAAGGDL 102 Query: 114 NNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR 173 + ++ F ++ GL+Y+H I++RDLK NL ++ + +KI DFGL + Sbjct: 103 MMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCK 162 Query: 174 H---TDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHID 230 D + + T + APE++ Y + VD W +G ++ E+L G + FPG D + Sbjct: 163 EGMGYGDRTSTFCGTPEFLAPEVL-TETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEE 221 Query: 231 QLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLV 290 I+ + + A+ ++ ++L Sbjct: 222 VFDSIVN-------------------------------DEVRYPRFLSTEAISIMRRLLR 250 Query: 291 LDSDKRI-----TAAQALAHAYFA--QYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYD 343 + ++R+ A H +F + D+ V P+ + R+ + + Sbjct: 251 RNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGRE-DVSNFDDEFTS 309 Query: 344 EVISFVPP----PLDQEEME 359 E PP L +EE E Sbjct: 310 EAPILTPPREPRILSEEEQE 329 >4PWN-A nrPDB Length = 274 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 68/289 (23%), Positives = 125/289 (43%), Gaps = 39/289 (13%) Query: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 +G G++ +V DT+T + VA +L + +R E +LK ++H N++ D Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYD 76 Query: 89 VFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTD-DHVQFLIYQILRGLKYIHSA-- 144 + +++ + LVT LM L +K K+ ++ QIL+GL+++H+ Sbjct: 77 SWES--TVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTP 134 Query: 145 DIIHRDLKPSNLAVN-EDCELKILDFGLARHTD--DEMTGYVATRWYRAPEIMLNWMHYN 201 IIHRDLK N+ + +KI D GLA + T + APE+ Y+ Sbjct: 135 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMY--EEKYD 192 Query: 202 QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQS 261 ++VD+++ G M E+ T + + Q+ Y + Sbjct: 193 ESVDVYAFGMCMLEMATSEYPYSECQNAAQI-------------------------YRRV 227 Query: 262 LTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 + + +F V I P +++E + + D+R + L HA+F + Sbjct: 228 TSGVKPASFDKVAI---PEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >5UUU-A nrPDB Length = 547 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 63/300 (21%), Positives = 121/300 (40%), Gaps = 44/300 (14%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM---- 78 + +G G +G V TG A+K L + + + R++ + Sbjct: 199 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 258 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRG 137 ++ + F L D+ + G DL+ + ++ ++F +I+ G Sbjct: 259 DCPFIVCMSYAFHTPDKLSFILDL-----MNGGDLHYHLSQHGVFSEADMRFYAAEIILG 313 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM-TGYVATRWYRAPEIMLN 196 L+++H+ +++RDLKP+N+ ++E ++I D GLA + V T Y APE++ Sbjct: 314 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQK 373 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 256 + Y+ + D +S+GC++ +LL G + F D+ + I R+ T EL Sbjct: 374 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTMAVELPDSF------ 426 Query: 257 NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQALAHAYFAQY 311 +P LLE +L D ++R+ A + +F Sbjct: 427 ---------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 465 >1ZXE-A nrPDB Length = 303 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 68/320 (21%), Positives = 138/320 (43%), Gaps = 59/320 (18%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 ++ ++ +G GA+G V A + A+KK+ + + E+ LL + H+ Sbjct: 7 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLS---TILSEVMLLASLNHQY 63 Query: 83 VIGLLDVFTPARSL-------EEFNDVYL-VTHLMGADLNNIVKCQKLTD--DHVQFLIY 132 V+ + R+ ++ + +++ + + L +++ + L D L Sbjct: 64 VVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFR 123 Query: 133 QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD---------------- 176 QIL L YIHS IIHR+LKP N+ ++E +KI DFGLA++ Sbjct: 124 QILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGS 183 Query: 177 -DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLI 235 D +T + T Y A E++ HYN+ +D++S+G I E++ +P + ++++ ++ Sbjct: 184 SDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI-----YPFSTGMERVNIL 238 Query: 236 LRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDK 295 + L+ +S E ++ + ++ K ++ ++ D +K Sbjct: 239 KK---------LRSVSIEFPPDFDDNKMKVEKK---------------IIRLLIDHDPNK 274 Query: 296 RITAAQALAHAYFAQYHDPD 315 R A L + H + Sbjct: 275 RPGARTLLNSGWLPVKHQDE 294 >3A4O-X nrPDB Length = 286 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 68/246 (27%), Positives = 117/246 (47%), Gaps = 21/246 (8%) Query: 14 NKTIWEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYREL 72 +K WE+P E + + +G+G +G V + + +VAVK L S+ + E Sbjct: 4 DKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNS-TKVAVKTLKPGTMSV---QAFLEEA 59 Query: 73 RLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKC---QKLTDDHVQ 128 L+K ++H+ ++ L V T +Y++T M L + +K K+ + Sbjct: 60 NLMKTLQHDKLVRLYAVVTREEP------IYIITEYMAKGSLLDFLKSDEGGKVLLPKLI 113 Query: 129 FLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-EMTGYVATRW 187 QI G+ YI + IHRDL+ +N+ V+E KI DFGLAR +D E T ++ Sbjct: 114 DFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKF 173 Query: 188 ---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPG 243 + APE + N+ + D+WS G ++ E++T G+ +PG + D + + + P Sbjct: 174 PIKWTAPEAI-NFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPR 232 Query: 244 AELLKK 249 E Sbjct: 233 VENCPD 238 >3PVW-A nrPDB Length = 695 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 63/300 (21%), Positives = 121/300 (40%), Gaps = 44/300 (14%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM---- 78 + +G G +G V TG A+K L + + + R++ + Sbjct: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRG 137 ++ + F L D+ + G DL+ + ++ ++F +I+ G Sbjct: 250 DCPFIVCMSYAFHTPDKLSFILDL-----MNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM-TGYVATRWYRAPEIMLN 196 L+++H+ +++RDLKP+N+ ++E ++I D GLA + V T Y APE++ Sbjct: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQK 364 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 256 + Y+ + D +S+GC++ +LL G + F D+ + I R+ T EL Sbjct: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTMAVELPDSF------ 417 Query: 257 NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQALAHAYFAQY 311 +P LLE +L D ++R+ A + +F Sbjct: 418 ---------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 >3LLT-A nrPDB Length = 360 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 73/363 (20%), Positives = 141/363 (38%), Gaps = 65/363 (17%) Query: 2 SQERPTFYRQELNKTI---WE----VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKK 54 S R Y Q ++ + W+ + + + +G G +G V AVK Sbjct: 8 SSGRENLYFQGDDEIVHFSWKKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKV 67 Query: 55 LSRPFQSIIHAKRTYRELRLLKHMKHENV-----IGLLDVFTPARSLEEFNDVYLVTHLM 109 + + AK E +LK ++++++ + ++ + L+ + Sbjct: 68 VRNIKKYTRSAKI---EADILKKIQNDDINNNNIVKYHG------KFMYYDHMCLIFEPL 118 Query: 110 GADLNNIV---KCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE------ 160 G L I+ + ++ +IL+ L Y+ + H DLKP N+ +++ Sbjct: 119 GPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKS 178 Query: 161 -------------------DCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYN 201 +K++DFG A D + TR YRAPE++LN + ++ Sbjct: 179 LITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKSDYHGSIINTRQYRAPEVILN-LGWD 237 Query: 202 QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQS 261 + D+WS GC++AEL TG LF +H++ L ++ ++ +L + + + Y+ Sbjct: 238 VSSDMWSFGCVLAELYTGSLLFRTHEHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNK 297 Query: 262 LT---------------QMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHA 306 + K I + L D L +L +D R + A+ L H Sbjct: 298 DELKLAWPENASSINSIKHVKKCLPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHK 357 Query: 307 YFA 309 + Sbjct: 358 FLE 360 >2XNP-A nrPDB Length = 279 Score = 203 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 68/303 (22%), Positives = 122/303 (40%), Gaps = 49/303 (16%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E Y+ L +G+G+YG G + K+L + + E+ LL+ +KH Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV-----KCQKLTDDHVQFLIYQIL 135 N++ D +Y+V G DL +++ + Q L ++ V ++ Q+ Sbjct: 66 NIVRYYDRIID----RTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLT 121 Query: 136 RGLKYIHSAD-----IIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM---TGYVATRW 187 LK H ++HRDLKP+N+ ++ +K+ DFGLAR + + +V T + Sbjct: 122 LALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPY 181 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247 Y +PE +N M YN+ DIWS+GC++ EL F + I Sbjct: 182 YMSPE-QMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKI------------ 228 Query: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 307 + F + + +++ +ML L R + + L + Sbjct: 229 ------------------REGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPL 270 Query: 308 FAQ 310 + Sbjct: 271 ILE 273 >4KIK-B nrPDB Length = 677 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 78/292 (26%), Positives = 128/292 (43%), Gaps = 25/292 (8%) Query: 17 IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 WE+ ER +G+G +G+V + +TG ++A+K+ + S + +R E+++++ Sbjct: 20 AWEMKER------LGTGGFGNVIRWHNQETGEQIAIKQCRQEL-SPRNRERWCLEIQIMR 72 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVK----CQKLTDDHVQFLI 131 + H NV+ DV ++L + L G DL + C L + + L+ Sbjct: 73 RLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLL 132 Query: 132 YQILRGLKYIHSADIIHRDLKPSNLAVNEDCE---LKILDFGLARHTDDE--MTGYVATR 186 I L+Y+H IIHRDLKP N+ + + + KI+D G A+ D T +V T Sbjct: 133 SDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTL 192 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 Y APE +L Y TVD WS G + E +TG F Q +R Sbjct: 193 QYLAPE-LLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDI-- 249 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT 298 + SE ++ + +P N N + L+ ML+ +R T Sbjct: 250 ---VVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKW--LQLMLMWHPRQRGT 296 >5HI2-A nrPDB Length = 283 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 63/286 (22%), Positives = 128/286 (44%), Gaps = 30/286 (10%) Query: 14 NKTIWEVPE-RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYREL 72 + WE+P+ + +GSG++G+V VAVK L + + E+ Sbjct: 11 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML-----TPQQLQAFKNEV 62 Query: 73 RLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTH-LMGADLNNIVKCQ--KLTDDHVQF 129 +L+ +H N++ + T + + +VT G+ L + + K + Sbjct: 63 GVLRKTRHVNILLFMGYSTKPQ-------LAIVTQWCEGSSLYHHLHASETKFEMKKLID 115 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEMTGYVA 184 + Q RG+ Y+H+ IIHRDLK +N+ ++ED +KI DFGLA + Sbjct: 116 IARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSG 175 Query: 185 TRWYRAPEIM--LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQ-LKLILRLVGT 241 + + APE++ + Y+ D+++ G ++ EL+TG+ + ++ DQ ++++ R + Sbjct: 176 SILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLS 235 Query: 242 PGAELLKKISSESARNYIQSLTQMP---KMNFANVFIGANPLAVDL 284 P ++ + + + + + +F + LA +L Sbjct: 236 PDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL 281 >1TKI-A nrPDB Length = 321 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 67/298 (22%), Positives = 126/298 (42%), Gaps = 42/298 (14%) Query: 19 EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 E+ E+Y +G G +G V +T + K + + K+ E+ +L Sbjct: 2 ELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKK---EISILNIA 58 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ--KLTDDHVQFLIYQILR 136 +H N++ L + F L V + + G D+ + +L + + ++Q+ Sbjct: 59 RHRNILHLHESFESMEEL-----VMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCE 113 Query: 137 GLKYIHSADIIHRDLKPSNLA--VNEDCELKILDFGLARHT--DDEMTGYVATRWYRAPE 192 L+++HS +I H D++P N+ +KI++FG AR D Y APE Sbjct: 114 ALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPE 173 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 + + + + D+WS+G ++ LL+G F + ++ I+ T E K+IS Sbjct: 174 VHQHDV-VSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISI 232 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 E A+D ++++LV + R+TA++AL H + Q Sbjct: 233 E---------------------------AMDFVDRLLVKERKSRMTASEALQHPWLKQ 263 >3C51-A nrPDB Length = 543 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 120/302 (39%), Gaps = 49/302 (16%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHA-KRTYRELRLLKHMKHEN 82 + + +G G +G V A TG A KKL++ + E ++L + Sbjct: 187 FLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRF 246 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV-----KCQKLTDDHVQFLIYQILR 136 ++ L F E D+ LV +M G D+ + + F QI+ Sbjct: 247 IVSLAYAF------ETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVS 300 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA---RHTDDEMTGYVATRWYRAPEI 193 GL+++H +II+RDLKP N+ +++D ++I D GLA + + GY T + APE+ Sbjct: 301 GLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPEL 360 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 +L Y+ +VD +++G + E++ R F K + E Sbjct: 361 LLGEE-YDFSVDYFALGVTLYEMIAARGPFRARGE-------------------KVENKE 400 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQALAHAYF 308 + ++ P +P + D E +L D +KR+ + H F Sbjct: 401 LKQRVLEQAVTYPDK--------FSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLF 452 Query: 309 AQ 310 Sbjct: 453 RD 454 >4OTD-A nrPDB Length = 341 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 64/344 (18%), Positives = 130/344 (37%), Gaps = 52/344 (15%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHA-KRTYRELRLLKHM-- 78 E ++ L+ +G G +G V + +G A+K L + + E R+L + Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 71 Query: 79 -KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 137 H ++ L F + +++ + G DL + ++ F ++ G Sbjct: 72 AGHPFLVNLFGCFQTPEHV-----CFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLG 126 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH---TDDEMTGYVATRWYRAPEIM 194 L+++H I++RDLK NL ++ + +KI DFGL + D + + T + APE++ Sbjct: 127 LQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL 186 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 + Y + VD W +G ++ E+L G + FPG D + I+ Sbjct: 187 TD-TSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN----------------- 228 Query: 255 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQALAHAYFA 309 + + A+ ++ ++L + ++R+ A +F Sbjct: 229 --------------DEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFR 274 Query: 310 QYHDPDDEP--VADPYDQSFESRDLLIDEWKSLTYDEVISFVPP 351 + P+ + R + + E + PP Sbjct: 275 TLGWEALLARRLPPPFVPTLSGR-TDVSNFDEEFTGEAPTLSPP 317 >5TQX-A nrPDB Length = 655 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 75/289 (25%), Positives = 124/289 (42%), Gaps = 24/289 (8%) Query: 17 IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 WE+ ER +G+G +G+VC + L++A+K S + +R E++++K Sbjct: 9 PWEMRER------LGTGGFGNVCLYQHRELDLKIAIKSCRLEL-STKNRERWCHEIQIMK 61 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK----CQKLTDDHVQFLIY 132 + H NV+ DV L + + + G DL ++ C L + + L+ Sbjct: 62 KLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLS 121 Query: 133 QILRGLKYIHSADIIHRDLKPSNLAV-NEDCEL--KILDFGLARHTD--DEMTGYVATRW 187 I G++Y+H IIHRDLKP N+ + + ++ KI+D G A+ D + T +V T Sbjct: 122 DIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQ 181 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247 Y APE+ N Y TVD WS G ++ E + G F H+ ++ + Sbjct: 182 YLAPELFEN-KPYTATVDYWSFGTMVFECIAGYRPF--LHHLQPFTWHEKIKKKDPKCIF 238 Query: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKR 296 + L Q + V N L+ ML D +R Sbjct: 239 ACEEMSGEVRFSSHLPQPNSLCSLIVEPMENW-----LQLMLNWDPQQR 282 >5MJB-A nrPDB Length = 305 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 58/240 (24%), Positives = 103/240 (42%), Gaps = 25/240 (10%) Query: 25 QNLSPVGSGAYGSVCAAFDTKTGLR---VAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 + +G+G +G V G R VA+K L + S + E ++ H Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-SEKQRRDFLSEASIMGQFDHR 87 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ--KLTDDHVQFLIYQILRGL 138 N+I L V T +R V ++T M L++ ++ + T + ++ I G+ Sbjct: 88 NIIRLEGVVTKSRP------VMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGM 141 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT---------GYVATRWYR 189 KY+ + +HRDL N+ VN + K+ DFGL+R+ D+ + G + RW Sbjct: 142 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRW-T 200 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 APE + + + D+WS G +M E+++ G + + D + I + P Sbjct: 201 APEAIA-YRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCP 259 >4XCU-A nrPDB Length = 300 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 73/312 (23%), Positives = 118/312 (37%), Gaps = 62/312 (19%) Query: 15 KTIWEVP-ERYQNLSPVGSGAYGSVCAAF-------DTKTGLRVAVKKLSRPFQSIIHAK 66 +WE P +R P+G G +G V A VAVK L + S Sbjct: 9 DPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKML-KDNASDKDLA 67 Query: 67 RTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK---- 121 E+ ++K + +H+N+I LL V T L +V +L ++ ++ Sbjct: 68 DLVSEMEVMKLIGRHKNIINLLGVCTQEGPL-----YVIVECAAKGNLREFLRARRPPGS 122 Query: 122 ----LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD 177 L+ + YQ+ RG++Y+ S IHRDL N+ V ED +KI DFGLAR Sbjct: 123 SEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHH 182 Query: 178 ------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHID 230 G + +W APE + + + Y D+WS G ++ E+ T G + +PG + Sbjct: 183 IDYYKKTSNGRLPVKW-MAPEALFDRV-YTHQSDVWSFGILLWEIFTLGGSPYPGIPVEE 240 Query: 231 QLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLV 290 L+ + + + P L+ + Sbjct: 241 LFSLL------------------------------REGHRMDRPPHCPPELYGLMRECWH 270 Query: 291 LDSDKRITAAQA 302 +R T Q Sbjct: 271 AAPSQRPTFKQL 282 >3TT0-A nrPDB Length = 382 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 72/275 (26%), Positives = 115/275 (41%), Gaps = 51/275 (18%) Query: 6 PTFYRQEL----------NKTIWEVP-ERYQNLSPVGSGAYGSVCAA------FDTKTGL 48 Y Q + WE+P +R P+G GA+G V A D + Sbjct: 42 ENLYFQGMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRV 101 Query: 49 -RVAVKKLSRPFQSIIHAKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVT 106 +VAVK L + + E+ ++K + KH+N+I LL T L +V Sbjct: 102 TKVAVKML-KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVE 155 Query: 107 HLMGADLNNIVKCQK-----------------LTDDHVQFLIYQILRGLKYIHSADIIHR 149 + +L ++ ++ L+ + YQ+ RG++Y+ S IHR Sbjct: 156 YASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHR 215 Query: 150 DLKPSNLAVNEDCELKILDFGLARHTDD------EMTGYVATRWYRAPEIMLNWMHYNQT 203 DL N+ V ED +KI DFGLAR G + +W APE + + + Y Sbjct: 216 DLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKW-MAPEALFDRI-YTHQ 273 Query: 204 VDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILR 237 D+WS G ++ E+ T G + +PG + KL+ Sbjct: 274 SDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKE 308 >4EQM-A nrPDB Length = 294 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 17/272 (6%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHA-KRTYRELRLLKHM 78 + ERY+ + +G G +V A DT ++VA+K + P + KR RE+ + Sbjct: 9 INERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQL 68 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHL-MGADLNNIVKCQK-LTDDHVQFLIYQILR 136 H+N++ ++DV EE + YLV G L+ ++ L+ D QIL Sbjct: 69 SHQNIVSMIDV------DEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILD 122 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD----EMTGYVATRWYRAPE 192 G+K+ H I+HRD+KP N+ ++ + LKI DFG+A+ + + + T Y +PE Sbjct: 123 GIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPE 182 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 ++ DI+S+G ++ E+L G F G + + ++ + + + Sbjct: 183 -QAKGEATDECTDIYSIGIVLYEMLVGEPPFNGET---AVSIAIKHIQDSVPNVTTDVRK 238 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDL 284 + ++ + + + + AN + + DL Sbjct: 239 DIPQSLSNVILRATEKDKANRYKTIQEMKDDL 270 >2Y6O-A nrPDB Length = 291 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 56/237 (23%), Positives = 98/237 (41%), Gaps = 21/237 (8%) Query: 25 QNLSPVGSGAYGSVCAAFDTKTGLR---VAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 + +G G +G VC+ G R VA+K L + + E ++ H Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTD-KQRRDFLSEASIMGQFDHP 75 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ--KLTDDHVQFLIYQILRGL 138 N+I L V T + V ++T M L+ ++ + T + ++ I G+ Sbjct: 76 NIIHLEGVVTKCKP------VMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGM 129 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW------YRAPE 192 KY+ +HRDL N+ VN + K+ DFG++R +D+ TR + APE Sbjct: 130 KYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPE 189 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 + + + D+WS G +M E+++ G + + D +K I P Sbjct: 190 AIA-YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCP 245 >5H2U-A nrPDB Length = 267 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 60/254 (23%), Positives = 120/254 (47%), Gaps = 19/254 (7%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E + +GSG +G V ++VA+K +SR +++H + E++ +K ++H+ Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISRD--NLLHQQMLQSEIQAMKKLRHK 62 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVK---CQKLTDDHVQFLIYQILRG 137 +++ L V + + VY++T LM L +++ + L + + +Q+ G Sbjct: 63 HILALYAVVSVG------DPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEG 116 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRW-YRAPEIM 194 + Y+ S + IHRDL N+ V E+ K+ DFGLAR ++ ++ + + APE + Sbjct: 117 MCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEAL 176 Query: 195 LNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGA-ELLKKISS 252 + HY+ D+WS G ++ E+ + G+ +PG + + + P E + Sbjct: 177 -SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHK 235 Query: 253 ESARNYIQSLTQMP 266 + + Q P Sbjct: 236 LMLTCWCRDPEQRP 249 >6E4F-A nrPDB Length = 290 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 56/253 (22%), Positives = 112/253 (44%), Gaps = 23/253 (9%) Query: 6 PTFYRQE---LNKTIWEV-PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 Y Q L WE+ P+ L +G+G +G V VA+K + + Sbjct: 11 ENLYFQGTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIK---EG 66 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVK-- 118 + E +++ ++ HE ++ L V T R ++++T M L N ++ Sbjct: 67 SMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRP------IFIITEYMANGCLLNYLREM 120 Query: 119 CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-DD 177 + + + + ++Y+ S +HRDL N VN+ +K+ DFGL+R+ DD Sbjct: 121 RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDD 180 Query: 178 EMTGYVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLK 233 E T V +++ + PE+++ + ++ DIW+ G +M E+ + G+ + + + + Sbjct: 181 EYTSSVGSKFPVRWSPPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAE 239 Query: 234 LILRLVGTPGAEL 246 I + + L Sbjct: 240 HIAQGLRLYRPHL 252 >5L6P-A nrPDB Length = 298 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 57/240 (23%), Positives = 104/240 (43%), Gaps = 25/240 (10%) Query: 25 QNLSPVGSGAYGSVCAAFDTKTGLR---VAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 + +G+G +G VC + G R VA+K L + + E ++ H Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTE-RQRRDFLSEASIMGQFDHP 80 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ--KLTDDHVQFLIYQILRGL 138 N+I L V T +R V ++T M L++ ++ + T + ++ I G+ Sbjct: 81 NIIRLEGVVTKSRP------VMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGM 134 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---------MTGYVATRWYR 189 KY+ + +HRDL N+ VN + K+ DFGL+R +D+ + G + RW Sbjct: 135 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRW-T 193 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 APE + + + D+WS G +M E+++ G + + D + + + P Sbjct: 194 APEAIA-YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCP 252 >3QA8-A nrPDB Length = 676 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 67/217 (30%), Positives = 103/217 (47%), Gaps = 18/217 (8%) Query: 17 IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 WE+ ER +G+G +G V TG +VA+K+ + S + +R E++++K Sbjct: 15 PWEMKER------LGTGGFGYVLRWIHQDTGEQVAIKQCRQEL-SPKNRERWCLEIQIMK 67 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVK----CQKLTDDHVQFLI 131 + H NV+ +V + L + L G DL + C L + ++ L+ Sbjct: 68 KLNHPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLL 127 Query: 132 YQILRGLKYIHSADIIHRDLKPSNLAVNEDCE---LKILDFGLARHTD--DEMTGYVATR 186 I L+Y+H IIHRDLKP N+ + + KI+D G A+ D + T +V T Sbjct: 128 SDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTL 187 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLF 223 Y APE +L Y TVD WS G + E +TG F Sbjct: 188 QYLAPE-LLEQKKYTVTVDYWSFGTLAFECITGFRPF 223 >4WUA-A nrPDB Length = 401 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 90/366 (24%), Positives = 147/366 (40%), Gaps = 84/366 (22%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH-- 80 RY + +G G + +V ++D + VA+K + + + + E+RLLK +++ Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK---SAEHYTETALDEIRLLKSVRNSD 98 Query: 81 EN------VIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKC--QKLTDDHVQFLI 131 N V+ LLD F + + +V ++G L I+K Q L V+ +I Sbjct: 99 PNDPNREMVVQLLDDFKISGV--NGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKII 156 Query: 132 YQILRGLKYIHSA-DIIHRDLKPSNLAVN------------------------------- 159 Q+L+GL Y+H+ IIH D+KP N+ ++ Sbjct: 157 QQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVST 216 Query: 160 ------------------EDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYN 201 E ++KI D G A T + TR YR+ E+++ YN Sbjct: 217 APATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGS-GYN 275 Query: 202 QTVDIWSVGCIMAELLTGRTLFPGTD------HIDQLKLILRLVGTPGAELL--KKISSE 253 DIWS C+ EL TG LF D + LI+ L+G +L+ K S E Sbjct: 276 TPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKE 335 Query: 254 --SARNYIQSLTQMPKMNFANVFIGANPL-------AVDLLEKMLVLDSDKRITAAQALA 304 + + ++ +T++ V + D L ML L +KR TAA+ L Sbjct: 336 FFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLR 395 Query: 305 HAYFAQ 310 H + Sbjct: 396 HPWLNS 401 >2J0K-A nrPDB Length = 656 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 61/288 (21%), Positives = 107/288 (37%), Gaps = 52/288 (18%) Query: 22 ERYQNLSPVGSGAYGSVCAAFD---TKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 ER + +G G +G V + VA+K + S ++ +E ++ Sbjct: 390 ERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTC-KNCTSDSVREKFLQEALTMRQF 448 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQKLTDDHVQF--LIYQIL 135 H +++ L+ V T N V+++ L +L + ++ +K + D YQ+ Sbjct: 449 DHPHIVKLIGVITE-------NPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLS 501 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM-----TGYVATRWYRA 190 L Y+ S +HRD+ N+ V+ +K+ DFGL+R+ +D G + +W A Sbjct: 502 TALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKW-MA 560 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 PE + N+ + D+W G M E+L G F G + D + I P Sbjct: 561 PESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMP----- 614 Query: 250 ISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI 297 P L+ K D +R Sbjct: 615 -------------------------PNCPPTLYSLMTKCWAYDPSRRP 637 >2JD5-A nrPDB Length = 373 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 80/326 (24%), Positives = 143/326 (43%), Gaps = 44/326 (13%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE- 81 RY + +G G + +V A D VA+K + ++ + E++LL+ + Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR---GDKVYTEAAEDEIKLLQRVNDAD 76 Query: 82 ----------NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK---CQKLTDDHVQ 128 +++ LLD F V +V ++G +L ++K + + +V+ Sbjct: 77 NTKEDSMGANHILKLLDHFNHKGP--NGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVK 134 Query: 129 FLIYQILRGLKYIHSA-DIIHRDLKPSNLAVN-----EDC-ELKILDFGLARHTDDEMTG 181 + Q+L GL Y+H IIH D+KP N+ + E+ ++KI D G A D+ T Sbjct: 135 QISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYTN 194 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTD------HIDQLKLI 235 + TR YR+PE++L + DIWS C++ EL+TG LF + D + I Sbjct: 195 SIQTREYRSPEVLLG-APWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQI 253 Query: 236 LRLVGTPGAELLKKISSE----SARNYIQSLTQMPKMNFANVFIGANPLAV-------DL 284 + L+G + LL+ ++R +++++++ +V + D Sbjct: 254 IELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDF 313 Query: 285 LEKMLVLDSDKRITAAQALAHAYFAQ 310 L ML LD KR A + H + Sbjct: 314 LSPMLQLDPRKRADAGGLVNHPWLKD 339 >3CJF-A nrPDB Length = 309 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 73/305 (23%), Positives = 125/305 (40%), Gaps = 43/305 (14%) Query: 10 RQELNKTIWEVP-ERYQNLSPVGSGAYGSVCAA----FDT-KTGLRVAVKKLSRPFQSII 63 R + + WE P +R P+G GA+G V A D T VAVK L Sbjct: 14 RLPYDASKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE 73 Query: 64 HAKRTYRELRLLKHMKHE-NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK- 121 H EL++L H+ H NV+ LL T + +V +L+ ++ ++ Sbjct: 74 HR-ALMSELKILIHIGHHLNVVNLLGACTKPG----GPLMVIVEFCKFGNLSTYLRSKRN 128 Query: 122 ------------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDF 169 LT +H+ +Q+ +G++++ S IHRDL N+ ++E +KI DF Sbjct: 129 EFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDF 188 Query: 170 GLARHT-DDEMTGYVATRW----YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLF 223 GLAR D + APE + + + Y D+WS G ++ E+ + G + + Sbjct: 189 GLARDIYKDPDYVRKGDARLPLKWMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPY 247 Query: 224 PGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVD 283 PG ++ LK+ + A +Y ++ + P + Sbjct: 248 PGVKIDEEFCR-----------RLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSE 296 Query: 284 LLEKM 288 L+E + Sbjct: 297 LVEHL 301 >4UY9-A nrPDB Length = 323 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 74/307 (24%), Positives = 119/307 (38%), Gaps = 47/307 (15%) Query: 28 SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHA--KRTYRELRLLKHMKHENVIG 85 +G G +G V AF G VAVK I + +E +L +KH N+I Sbjct: 15 EIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIA 72 Query: 86 LLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSA 144 L V +L LV G LN ++ +++ D + QI RG+ Y+H Sbjct: 73 LRGVCLKEPNL------CLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDE 126 Query: 145 ---DIIHRDLKPSNLAV--------NEDCELKILDFGLARHTDDEMT-GYVATRWYRAPE 192 IIHRDLK SN+ + + LKI DFGLAR T + APE Sbjct: 127 AIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPE 186 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI--------------------DQL 232 ++ M +++ D+WS G ++ ELLTG F G D + + Sbjct: 187 VIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPF 245 Query: 233 KLILRLVGTPGAELLKKISS---ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKML 289 ++ P ++ + +MPK +F + ++ +++ Sbjct: 246 AKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLR 305 Query: 290 VLDSDKR 296 + + R Sbjct: 306 AKEKELR 312 >2X7G-A nrPDB Length = 389 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 85/364 (23%), Positives = 141/364 (38%), Gaps = 82/364 (22%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK--- 79 RY + +G G + +V +D + VA+K + + + + E++LLK ++ Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK---SAQHYTETALDEIKLLKCVRESD 88 Query: 80 --HEN---VIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKC--QKLTDDHVQFLI 131 N V+ L+D F + V +V ++G L I+K Q L V+ +I Sbjct: 89 PSDPNKDMVVQLIDDFKISGM--NGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSII 146 Query: 132 YQILRGLKYIHSA-DIIHRDLKPSNLAV-------------------------------- 158 Q+L+GL Y+HS IIH D+KP N+ + Sbjct: 147 RQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVST 206 Query: 159 ---------------NEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQT 203 + +KI D G A T + TR YR+ E+++ Y+ Sbjct: 207 APAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIG-AGYSTP 265 Query: 204 VDIWSVGCIMAELLTGRTLFPGTD------HIDQLKLILRLVGTPGAE--LLKKISSESA 255 DIWS C+ EL TG LF D + I+ L+G+ L K S E Sbjct: 266 ADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFF 325 Query: 256 --RNYIQSLTQMPKMNFANVFIGANPL-------AVDLLEKMLVLDSDKRITAAQALAHA 306 R ++ +T++ + +V + D L ML + +KR +A + L H Sbjct: 326 NRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHP 385 Query: 307 YFAQ 310 + Sbjct: 386 WLNS 389 >5HIE-A nrPDB Length = 302 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 62/286 (21%), Positives = 126/286 (44%), Gaps = 30/286 (10%) Query: 14 NKTIWEVPE-RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYREL 72 + WE+P+ + +GSG++G+V VAVK L + + E+ Sbjct: 27 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML-----TPQQLQAFKNEV 78 Query: 73 RLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTH-LMGADLNNIVK--CQKLTDDHVQF 129 +L+ +H N++ + T + + +VT G+ L + + K + Sbjct: 79 GVLRKTRHVNILLFMGYSTKPQ-------LAIVTQWCEGSSLYHHLHIIETKFEMIKLID 131 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEMTGYVA 184 + Q +G+ Y+H+ IIHRDLK +N+ ++ED +KI DFGLA + Sbjct: 132 IARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSG 191 Query: 185 TRWYRAPEIM--LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQ-LKLILRLVGT 241 + + APE++ + Y+ D+++ G ++ EL+TG+ + ++ DQ + ++ R + Sbjct: 192 SILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLS 251 Query: 242 PGAELLKKISSESARNYIQSLTQMPKMN---FANVFIGANPLAVDL 284 P ++ ++ + + + + F + LA L Sbjct: 252 PDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL 297 >4UYA-A nrPDB Length = 340 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 70/278 (25%), Positives = 113/278 (40%), Gaps = 27/278 (9%) Query: 6 PTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVK--KLSRPFQSII 63 Y Q + ER + +G+G +G V A G VAVK + + Sbjct: 12 ENLYFQGSPVHV--AFERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAA 67 Query: 64 HAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKL 122 A+ RE RL ++H N+I L V + LV G LN + +++ Sbjct: 68 AAESVRREARLFAMLRHPNIIELRGVCLQQP------HLCLVLEFARGGALNRALAGRRI 121 Query: 123 TDDHVQFLIYQILRGLKYIHSA---DIIHRDLKPSNLAVNE--------DCELKILDFGL 171 + QI RG+ Y+H I+HRDLK SN+ + E + LKI DFGL Sbjct: 122 PPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGL 181 Query: 172 ARHTDDEMT-GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHID 230 AR + APE++ + + +++ DIWS G ++ ELLTG + G D + Sbjct: 182 AREWHRTTKMATAGAYAWMAPEVIKSSL-FSKGSDIWSYGVLLWELLTGEVPYRGIDGLA 240 Query: 231 Q-LKLILRLVGTPGAELLKKISSESARNYIQSLTQMPK 267 + + + P + ++ + Q + Sbjct: 241 VAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRP 278 >2PL0-A nrPDB Length = 289 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 68/259 (26%), Positives = 122/259 (47%), Gaps = 25/259 (9%) Query: 1 MSQERPTFYRQELNKTIWEVPER-YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF 59 M ++P + + WEVP + + +G+G +G V + +VAVK L Sbjct: 4 MQTQKPQ---KPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNG-HTKVAVKSLK--- 56 Query: 60 QSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVK 118 Q + E L+K ++H+ ++ L V T +Y++T M L + +K Sbjct: 57 QGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQE-------PIYIITEYMENGSLVDFLK 109 Query: 119 CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT 175 KLT + + + QI G+ +I + IHRDL+ +N+ V++ KI DFGLAR Sbjct: 110 TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI 169 Query: 176 DD-EMTGYVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHID 230 +D E T ++ + APE + N+ + D+WS G ++ E++T GR +PG + + Sbjct: 170 EDNEYTAREGAKFPIKWTAPEAI-NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPE 228 Query: 231 QLKLILRLVGTPGAELLKK 249 ++ + R + + Sbjct: 229 VIQNLERGYRMVRPDNCPE 247 >2HK5-A nrPDB Length = 270 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 67/245 (27%), Positives = 115/245 (46%), Gaps = 22/245 (8%) Query: 15 KTIWEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELR 73 K WE+P E + +G+G +G V A K +VAVK + S+ + E Sbjct: 7 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMSV---EAFLAEAN 62 Query: 74 LLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKC---QKLTDDHVQF 129 ++K ++H+ ++ L V T +Y++T M L + +K K + Sbjct: 63 VMKTLQHDKLVKLHAVVTKE-------PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID 115 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-EMTGYVATRW- 187 QI G+ +I + IHRDL+ +N+ V+ KI DFGLAR +D E T ++ Sbjct: 116 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP 175 Query: 188 --YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGA 244 + APE + N+ + D+WS G ++ E++T GR +PG + + ++ + R P Sbjct: 176 IKWTAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP 234 Query: 245 ELLKK 249 E + Sbjct: 235 ENCPE 239 >1JPA-A nrPDB Length = 312 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 61/263 (23%), Positives = 111/263 (42%), Gaps = 30/263 (11%) Query: 8 FYRQELNKTIWEVPERY-----QNLSPVGSGAYGSVCAAFDTKTGLR---VAVKKLSRPF 59 F ++ N+ + E + + +G+G +G VC+ G R VA+K L + Sbjct: 14 FTFEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY 73 Query: 60 QSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVK 118 + E ++ H NVI L V T + V ++T M L++ ++ Sbjct: 74 TE-KQRRDFLSEASIMGQFDHPNVIHLEGVVTKS------TPVMIITEFMENGSLDSFLR 126 Query: 119 CQ--KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD 176 + T + ++ I G+KY+ + +HRDL N+ VN + K+ DFGL+R + Sbjct: 127 QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLE 186 Query: 177 DEMT---------GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT 226 D+ + G + RW APE + + + D+WS G +M E+++ G + Sbjct: 187 DDTSDPTYTSALGGKIPIRW-TAPEAI-QYRKFTSASDVWSYGIVMWEVMSYGERPYWDM 244 Query: 227 DHIDQLKLILRLVGTPGAELLKK 249 + D + I + P Sbjct: 245 TNQDVINAIEQDYRLPPPMDCPS 267 >5A46-A nrPDB Length = 386 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 73/273 (26%), Positives = 116/273 (42%), Gaps = 45/273 (16%) Query: 2 SQERP---TFYRQELNKTI-WEVP-ERYQNLSPVGSGAYGSVCAA------FDTKTGL-R 49 S P EL + WE+P +R P+G G +G V A D + + Sbjct: 15 SSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTK 74 Query: 50 VAVKKLSRPFQSIIHAKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHL 108 VAVK L + + E+ ++K + KH+N+I LL T L +V + Sbjct: 75 VAVKML-KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYA 128 Query: 109 MGADLNNIVKCQK-----------------LTDDHVQFLIYQILRGLKYIHSADIIHRDL 151 +L ++ ++ L+ + YQ+ RG++Y+ S IHRDL Sbjct: 129 SKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDL 188 Query: 152 KPSNLAVNEDCELKILDFGLARHTDD------EMTGYVATRWYRAPEIMLNWMHYNQTVD 205 N+ V ED +KI DFGLAR G + +W APE + + + Y D Sbjct: 189 AARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKW-MAPEALFDRI-YTHQSD 246 Query: 206 IWSVGCIMAELLT-GRTLFPGTDHIDQLKLILR 237 +WS G ++ E+ T G + +PG + KL+ Sbjct: 247 VWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKE 279 >3G0E-A nrPDB Length = 336 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 73/327 (22%), Positives = 124/327 (37%), Gaps = 70/327 (21%) Query: 11 QELNKTIWEVPE-RYQNLSPVGSGAYGSVCAA-----FDTKTGLRVAVKKLSRPFQSIIH 64 Q WE P R +G+GA+G V A + + VAVK L +P + Sbjct: 34 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKML-KPSAHLTE 92 Query: 65 AKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-- 121 + EL++L ++ H N++ LL T + + + DL N ++ ++ Sbjct: 93 REALMSELKVLSYLGNHMNIVNLLGACTIGGP-----TLVITEYCCYGDLLNFLRRKRDS 147 Query: 122 -----------------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL 164 L + + YQ+ +G+ ++ S + IHRDL N+ + Sbjct: 148 FICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRIT 207 Query: 165 KILDFGLARHTDDEMTGYV------ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 KI DFGLAR ++ V +W APE + N + Y D+WS G + EL + Sbjct: 208 KICDFGLARDIKNDSNYVVKGNARLPVKW-MAPESIFNCV-YTFESDVWSYGIFLWELFS 265 Query: 219 -GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGA 277 G + +PG + +++ E + +S E A Sbjct: 266 LGSSPYPGMPVDSKFYKMIK-------EGFRMLSPEHAPA-------------------- 298 Query: 278 NPLAVDLLEKMLVLDSDKRITAAQALA 304 D+++ D KR T Q + Sbjct: 299 --EMYDIMKTCWDADPLKRPTFKQIVQ 323 >3GQL-A nrPDB Length = 326 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 70/253 (27%), Positives = 112/253 (44%), Gaps = 41/253 (16%) Query: 18 WEVP-ERYQNLSPVGSGAYGSVCAA------FDTKTGL-RVAVKKLSRPFQSIIHAKRTY 69 WE+P +R P+G GA+G V A D + +VAVK L + + Sbjct: 23 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKML-KSDATEKDLSDLI 81 Query: 70 RELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK------- 121 E+ ++K + KH+N+I LL T L +V + +L ++ ++ Sbjct: 82 SEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLQARRPPGLEYC 136 Query: 122 ----------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGL 171 L+ + YQ+ RG++Y+ S IHRDL N+ V ED +KI DFGL Sbjct: 137 YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGL 196 Query: 172 ARHTDD------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFP 224 AR G + +W APE + + + Y D+WS G ++ E+ T G + +P Sbjct: 197 ARDIHHIDYYKKTTNGRLPVKW-MAPEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYP 254 Query: 225 GTDHIDQLKLILR 237 G + KL+ Sbjct: 255 GVPVEELFKLLKE 267 >3OMV-A nrPDB Length = 307 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 64/284 (22%), Positives = 127/284 (44%), Gaps = 24/284 (8%) Query: 18 WEVPERYQNLSP-VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 WE+ LS +GSG++G+V VAVK L + + E+ +L+ Sbjct: 31 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFRNEVAVLR 87 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTH-LMGADLNNIVKCQ--KLTDDHVQFLIYQ 133 +H N++ + T +++ +VT G+ L + Q K + + Q Sbjct: 88 KTRHVNILLFMGYMTK-------DNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQ 140 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEMTGYVATRWY 188 +G+ Y+H+ +IIHRD+K +N+ ++E +KI DFGLA ++ + + Sbjct: 141 TAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLW 200 Query: 189 RAPEIM--LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQ-LKLILRLVGTPGAE 245 APE++ + ++ D++S G ++ EL+TG + ++ DQ + ++ R +P Sbjct: 201 MAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLS 260 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKML 289 L K ++ + + + K + ++LL+ L Sbjct: 261 KLYKNCPKAMKRLVADCVKKVKEERPLFPQILSS--IELLQHSL 302 >4P5Q-A nrPDB Length = 361 Score = 197 bits (501), Expect = 7e-51, Method: Composition-based stats. Identities = 53/234 (22%), Positives = 99/234 (42%), Gaps = 21/234 (8%) Query: 28 SPVGSGAYGSVCAAFDTKTGLR---VAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVI 84 VG+G +G VC+ + VA+K L + + E ++ H N+I Sbjct: 39 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTE-KQRRDFLGEASIMGQFDHPNII 97 Query: 85 GLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ--KLTDDHVQFLIYQILRGLKYI 141 L V T ++ V +VT M L++ ++ + T + ++ I G+KY+ Sbjct: 98 RLEGVVTKSKP------VMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYL 151 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW------YRAPEIML 195 +HRDL N+ +N + K+ DFGL+R +D+ TR + +PE + Sbjct: 152 SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIA 211 Query: 196 NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 + + D+WS G ++ E+++ G + + D +K + P Sbjct: 212 -YRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCP 264 >5X5O-A nrPDB Length = 310 Score = 197 bits (500), Expect = 9e-51, Method: Composition-based stats. Identities = 65/289 (22%), Positives = 108/289 (37%), Gaps = 54/289 (18%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 + Q G G++GSV A VAVKKL + +E +L + H Sbjct: 15 DDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK----------IEKEAEILSVLSHR 64 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQK---LTDDHVQFLIYQILRG 137 N+I V + +VT L + + + + DH+ + +G Sbjct: 65 NIIQFYGVILEPPNYG------IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKG 118 Query: 138 LKYIHSA---DIIHRDLKPSNLAVNEDCELKILDFGLAR-HTDDEMTGYVATRWYRAPEI 193 + Y+H +IHRDLK N+ + D LKI DFG +R H V T + APE+ Sbjct: 119 MHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEV 178 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 + + + ++T D +S G ++ E+LT F G + + L++ Sbjct: 179 IQS-LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVE---------------- 221 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQA 302 K + +LL + D+ KR + Q Sbjct: 222 -------------KNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQI 257 >4K33-A nrPDB Length = 325 Score = 197 bits (500), Expect = 9e-51, Method: Composition-based stats. Identities = 71/258 (27%), Positives = 110/258 (42%), Gaps = 41/258 (15%) Query: 13 LNKTIWEVPE-RYQNLSPVGSGAYGSVCAA----FDTKTGLR---VAVKKLSRPFQSIIH 64 WE+ R P+G GA+G V A D + VAVK L + + Sbjct: 26 PADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKML-KDDATDKD 84 Query: 65 AKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-- 121 E+ ++K + KH+N+I LL T L LV + +L ++ ++ Sbjct: 85 LSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL-----YVLVEYAAKGNLREFLRARRPP 139 Query: 122 ---------------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKI 166 LT + YQ+ RG++Y+ S IHRDL N+ V ED +KI Sbjct: 140 GLDYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKI 199 Query: 167 LDFGLARHTD------DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-G 219 DFGLAR + G + +W APE + + + Y D+WS G ++ E+ T G Sbjct: 200 ADFGLARDVHNLDYYKETTNGRLPVKW-MAPEALFDRV-YTHQSDVWSFGVLLWEIFTLG 257 Query: 220 RTLFPGTDHIDQLKLILR 237 + +PG + KL+ Sbjct: 258 GSPYPGIPVEELFKLLKE 275 >5B2L-A nrPDB Length = 324 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 66/298 (22%), Positives = 114/298 (38%), Gaps = 42/298 (14%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 +NL +GSG G V KTG +AVK++ R + + +LK Sbjct: 18 DLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPY 77 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC--QKLTDDHVQFLIYQILRGLKY 140 ++ F DV++ LMG + K + + + + I++ L Y Sbjct: 78 IVQCFGTFIT------NTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYY 131 Query: 141 I-HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIML-- 195 + +IHRD+KPSN+ ++E ++K+ DFG++ D T Y APE + Sbjct: 132 LKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPP 191 Query: 196 --NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 Y+ D+WS+G + EL TG+ + E+L K+ E Sbjct: 192 DPTKPDYDIRADVWSLGISLVELATGQFPYKN--------------CKTDFEVLTKVLQE 237 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311 + +G + ++ L D KR + L H++ +Y Sbjct: 238 -------------EPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRY 282 >6BXI-A nrPDB Length = 333 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 66/285 (23%), Positives = 107/285 (37%), Gaps = 53/285 (18%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKH 80 E +++L +G GA+G V TG A+K L + E +L Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 65 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV-KCQKLTDDHVQFLIYQILRGL 138 V+ + F ++ ++YL+ + G D+ ++ K LT++ QF I + + + Sbjct: 66 LWVVKMFYSF------QDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAI 119 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG----------------- 181 IH IHRD+KP NL ++ +K+ DFGL Sbjct: 120 DSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ 179 Query: 182 ---------------------YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGR 220 V T Y APE+ + YN+ D WS+G IM E+L G Sbjct: 180 NMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQ-TGYNKLCDWWSLGVIMYEMLIGY 238 Query: 221 TLFPGTDHIDQLKLIL--RLVGTPGAELLKKISSESARNYIQSLT 263 F + K ++ + T E+ SE A++ I Sbjct: 239 PPFCSETPQETYKKVMNWKETLTFPPEVP---ISEKAKDLILRFC 280 >3DTC-A nrPDB Length = 271 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 73/276 (26%), Positives = 112/276 (40%), Gaps = 35/276 (12%) Query: 28 SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHA--KRTYRELRLLKHMKHENVIG 85 +G G +G V AF G VAVK I + +E +L +KH N+I Sbjct: 13 EIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIA 70 Query: 86 LLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSA 144 L V +L LV G LN ++ +++ D + QI RG+ Y+H Sbjct: 71 LRGVCLKEPNL------CLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDE 124 Query: 145 ---DIIHRDLKPSNLAV--------NEDCELKILDFGLARHTDDEMT-GYVATRWYRAPE 192 IIHRDLK SN+ + + LKI DFGLAR + APE Sbjct: 125 AIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYAWMAPE 184 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 252 ++ M +++ D+WS G ++ ELLTG F G D L + + A + Sbjct: 185 VIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDG---LAVAYGVAMNKLALPIPSTCP 240 Query: 253 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKM 288 E ++ N + P ++L+++ Sbjct: 241 EPFAKLMEDCW--------NPDPHSRPSFTNILDQL 268 >2OGV-A nrPDB Length = 317 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 59/240 (24%), Positives = 101/240 (42%), Gaps = 33/240 (13%) Query: 11 QELNKTIWEVPER-YQNLSPVGSGAYGSVCAAFDTKTGLR-----VAVKKLSRPFQSIIH 64 Q WE P Q +G+GA+G V A G VAVK L + Sbjct: 26 QLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHADE 84 Query: 65 AKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC---- 119 + EL+++ H+ +HEN++ LL T + + + + DL N ++ Sbjct: 85 KEALMSELKIMSHLGQHENIVNLLGACTHGGPV-----LVITEYCCYGDLLNFLRRKAEA 139 Query: 120 -------QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA 172 + L + Q+ +G+ ++ S + IHRD+ N+ + KI DFGLA Sbjct: 140 DLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLA 199 Query: 173 RHTDDEM------TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPG 225 R ++ + +W APE + + + Y D+WS G ++ E+ + G +PG Sbjct: 200 RDIMNDSNYIVKGNARLPVKW-MAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYPG 257 >2VWV-A nrPDB Length = 302 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 62/293 (21%), Positives = 117/293 (39%), Gaps = 34/293 (11%) Query: 25 QNLSPVGSGAYGSVCAAFDTKTGLR---VAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 + +G+G +G VC G + VA+K L + + E ++ +H Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTE-RQRREFLSEASIMGQFEHP 77 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ--KLTDDHVQFLIYQILRGL 138 N+I L V T + V ++T M L++ ++ + T + ++ I G+ Sbjct: 78 NIIRLEGVVTNS------MPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGM 131 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT---------GYVATRWYR 189 +Y+ +HRDL N+ VN + K+ DFGL+R ++ + G + RW Sbjct: 132 RYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRW-T 190 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 APE + + + D WS G +M E+++ G + + D + I + P Sbjct: 191 APEAIA-FRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCP 249 Query: 249 KISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQ 301 + + Q + + F V L+KM+ + +I A + Sbjct: 250 TSLHQLMLDCWQ-KDRNARPRFPQVVSA--------LDKMIRNPASLKIVARE 293 >4XI2-A nrPDB Length = 446 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 54/244 (22%), Positives = 110/244 (45%), Gaps = 20/244 (8%) Query: 12 ELNKTIWEV-PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR 70 L WE+ P+ L +G+G +G V VA+K + + + Sbjct: 176 GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIR---EGSMSEDEFIE 231 Query: 71 ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVK--CQKLTDDHV 127 E +++ ++ HE ++ L V T R ++++T M L N ++ + + Sbjct: 232 EAKVMMNLSHEKLVQLYGVCTKQRP------IFIITEYMANGCLLNYLREMRHRFQTQQL 285 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-DDEMTGYVATR 186 + + ++Y+ S +HRDL N VN+ +K+ DFGL+R+ DDE T V ++ Sbjct: 286 LEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSK 345 Query: 187 W---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTP 242 + + PE+++ + ++ DIW+ G +M E+ + G+ + + + + I + + Sbjct: 346 FPVRWSPPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLY 404 Query: 243 GAEL 246 L Sbjct: 405 RPHL 408 >4Y93-A nrPDB Length = 446 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 53/244 (21%), Positives = 110/244 (45%), Gaps = 20/244 (8%) Query: 12 ELNKTIWEV-PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR 70 L WE+ P+ L +G+G +G V VA+K + + + Sbjct: 177 GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIK---EGSMSEDEFIE 232 Query: 71 ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVK--CQKLTDDHV 127 E +++ ++ HE ++ L V T R ++++T M L N ++ + + Sbjct: 233 EAKVMMNLSHEKLVQLYGVCTKQRP------IFIITEYMANGCLLNYLREMRHRFQTQQL 286 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-DDEMTGYVATR 186 + + ++Y+ S +HRDL N VN+ +K+ DFG+ R+ DDE T ++ Sbjct: 287 LEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSK 346 Query: 187 W---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTP 242 + + +PE+++ + ++ DIW+ G +M E+ + G+ + + + + I + + P Sbjct: 347 FPVKWASPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLP 405 Query: 243 GAEL 246 L Sbjct: 406 RPHL 409 >4AT3-A nrPDB Length = 299 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 62/290 (21%), Positives = 111/290 (38%), Gaps = 38/290 (13%) Query: 26 NLSPVGSGAYGSVCAAF-----DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH 80 +G GA+G V A + + VAVK L + K +RE LL +++H Sbjct: 17 LKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA--RKDFHREAELLTNLQH 74 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK--------------LTDDH 126 E+++ V L + + ++ DLN ++ LT Sbjct: 75 EHIVKFYGVCVEGDPL-----IMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQ 129 Query: 127 VQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVA-- 184 + + QI G+ Y+ S +HRDL N V E+ +KI DFG++R V Sbjct: 130 MLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGH 189 Query: 185 ---TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVG 240 + PE ++ + + D+WS+G ++ E+ T G+ + + + ++ I + Sbjct: 190 TMLPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRV 248 Query: 241 TPGAELLKKISSESARNYIQSLTQMPK-----MNFANVFIGANPLAVDLL 285 + E Q M K A+P+ +D+L Sbjct: 249 LQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDIL 298 >2PSQ-A nrPDB Length = 370 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 68/256 (26%), Positives = 110/256 (42%), Gaps = 41/256 (16%) Query: 15 KTIWEVP-ERYQNLSPVGSGAYGSVCAA----FDTKTGLR---VAVKKLSRPFQSIIHAK 66 WE P ++ P+G G +G V A D VAVK L + + Sbjct: 73 DPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML-KDDATEKDLS 131 Query: 67 RTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK---- 121 E+ ++K + KH+N+I LL T L +V + +L ++ ++ Sbjct: 132 DLVSEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLRARRPPGM 186 Query: 122 -------------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILD 168 +T + YQ+ RG++Y+ S IHRDL N+ V E+ +KI D Sbjct: 187 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 246 Query: 169 FGLARHTDD------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRT 221 FGLAR ++ G + +W APE + + + Y D+WS G +M E+ T G + Sbjct: 247 FGLARDINNIDYYKKTTNGRLPVKW-MAPEALFDRV-YTHQSDVWSFGVLMWEIFTLGGS 304 Query: 222 LFPGTDHIDQLKLILR 237 +PG + KL+ Sbjct: 305 PYPGIPVEELFKLLKE 320 >3BEA-A nrPDB Length = 333 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 59/244 (24%), Positives = 102/244 (41%), Gaps = 37/244 (15%) Query: 11 QELNKTIWEVPER-YQNLSPVGSGAYGSVCAAFDTKTGLR-----VAVKKLSRPFQSIIH 64 Q WE P Q +G+GA+G V A G VAVK L + Sbjct: 34 QLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHADE 92 Query: 65 AKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ--- 120 + EL+++ H+ +HEN++ LL T + + + + DL N ++ + Sbjct: 93 KEALMSELKIMSHLGQHENIVNLLGACTHGGPV-----LVITEYCCYGDLLNFLRRKSRV 147 Query: 121 ------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILD 168 L+ + Q+ +G+ ++ S + IHRD+ N+ + KI D Sbjct: 148 LETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGD 207 Query: 169 FGLARHTDDEM------TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRT 221 FGLAR ++ + +W APE + + + Y D+WS G ++ E+ + G Sbjct: 208 FGLARDIMNDSNYIVKGNARLPVKW-MAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLN 265 Query: 222 LFPG 225 +PG Sbjct: 266 PYPG 269 >2R2P-A nrPDB Length = 295 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 57/234 (24%), Positives = 99/234 (42%), Gaps = 21/234 (8%) Query: 28 SPVGSGAYGSVCAAFDTKTGLR---VAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVI 84 +G+G +G VC+ G R VA+K L + + E ++ H N+I Sbjct: 28 RVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTE-KQRRDFLGEASIMGQFDHPNII 86 Query: 85 GLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ--KLTDDHVQFLIYQILRGLKYI 141 L V T ++ V +VT M L+ +K + T + ++ I G+KY+ Sbjct: 87 HLEGVVTKSKP------VMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYL 140 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW------YRAPEIML 195 +HRDL N+ +N + K+ DFGL+R +D+ TR + APE + Sbjct: 141 SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA 200 Query: 196 NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 + + D+WS G +M E+++ G + + D +K + P Sbjct: 201 -FRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCP 253 >3DLS-A nrPDB Length = 335 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 65/311 (20%), Positives = 126/311 (40%), Gaps = 54/311 (17%) Query: 11 QELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP------FQSIIH 64 + L E ++Y +SP+GSGA+G V A D + V VK + + + Sbjct: 13 EGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPK 72 Query: 65 AKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLN---NIVKCQK 121 + E+ +L ++H N+I +LD+F + LV G+ L+ I + + Sbjct: 73 LGKVTLEIAILSRVEHANIIKVLDIFENQGFFQ------LVMEKHGSGLDLFAFIDRHPR 126 Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT--DDEM 179 L + ++ Q++ + Y+ DIIHRD+K N+ + ED +K++DFG A + Sbjct: 127 LDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLF 186 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239 + T Y APE+++ + +++WS+G + L+ F Sbjct: 187 YTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFC--------------- 231 Query: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITA 299 EL + + + Y+ + + L+ +L ++R T Sbjct: 232 -----ELEETVEAAIHPPYL-----------------VSKELMSLVSGLLQPVPERRTTL 269 Query: 300 AQALAHAYFAQ 310 + + + Q Sbjct: 270 EKLVTDPWVTQ 280 >3KRL-A nrPDB Length = 335 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 59/246 (23%), Positives = 103/246 (41%), Gaps = 39/246 (15%) Query: 11 QELNKTIWEVPER-YQNLSPVGSGAYGSVCAAFDTKTGLR-----VAVKKLSRPFQSIIH 64 Q WE P Q +G+GA+G V A G VAVK L + Sbjct: 34 QLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHADE 92 Query: 65 AKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-- 121 + EL+++ H+ +HEN++ LL T + + + + DL N ++ ++ Sbjct: 93 KEALMSELKIMSHLGQHENIVNLLGACTHGGPV-----LVITEYCCYGDLLNFLRRKRPP 147 Query: 122 ---------------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKI 166 L+ + Q+ +G+ ++ S + IHRD+ N+ + KI Sbjct: 148 GLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKI 207 Query: 167 LDFGLARHTDDEM------TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-G 219 DFGLAR ++ + +W APE + + + Y D+WS G ++ E+ + G Sbjct: 208 GDFGLARDIMNDSNYIVKGNARLPVKW-MAPESIFDCV-YTVQSDVWSYGILLWEIFSLG 265 Query: 220 RTLFPG 225 +PG Sbjct: 266 LNPYPG 271 >1K9A-A nrPDB Length = 450 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 69/311 (22%), Positives = 121/311 (38%), Gaps = 56/311 (18%) Query: 4 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII 63 + FYR + E+ + L +G G +G V G +VAVK + Sbjct: 179 AQDEFYRSGWALNMKEL----KLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDAT--- 229 Query: 64 HAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQK- 121 A+ E ++ ++H N++ LL V +EE +Y+VT M L + ++ + Sbjct: 230 -AQAFLAEASVMTQLRHSNLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGR 283 Query: 122 --LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM 179 L D + + ++Y+ + +HRDL N+ V+ED K+ DFGL + Sbjct: 284 SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ 343 Query: 180 -TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILR 237 TG + +W APE + ++ D+WS G ++ E+ + GR +P D + + + Sbjct: 344 DTGKLPVKW-TAPEAL-REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK 401 Query: 238 LVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI 297 + G P D+++ LD+ R Sbjct: 402 GYKMDAPD------------------------------GCPPAVYDVMKNCWHLDAATRP 431 Query: 298 TAAQA---LAH 305 T Q L H Sbjct: 432 TFLQLREQLEH 442 >4OLI-A nrPDB Length = 645 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 66/297 (22%), Positives = 111/297 (37%), Gaps = 37/297 (12%) Query: 20 VPERY-QNLSPVGSGAYGSVCA-AFDTK---TGLRVAVKKLSRPFQSIIHAKRTYRELRL 74 +RY + + +G G +G V +D TG VAVK L + H +E+ + Sbjct: 350 FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-KADCGPQHRSGWKQEIDI 408 Query: 75 LKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQKLTDDHVQFLIYQ 133 L+ + HE++I + LV + L + + + + Q Sbjct: 409 LRTLYHEHIIKYKGCCEDQGE----KSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQ 464 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV-------ATR 186 I G+ Y+HS IHR+L N+ ++ D +KI DFGLA+ + Y Sbjct: 465 ICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF 524 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 WY APE + + Y D+WS G + ELLT +P + Sbjct: 525 WY-APECLKEYKFY-YASDVWSFGVTLYELLTHC----------------DSSQSPPTKF 566 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGANP-LAVDLLEKMLVLDSDKRITAAQA 302 L+ I + + LT++ + P L++ ++ R T Sbjct: 567 LELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENL 623 Score = 99.2 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 44/312 (14%), Positives = 101/312 (32%), Gaps = 53/312 (16%) Query: 41 AFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFN 100 D LRV +K L I A Y L+ + H ++ + V Sbjct: 88 GRDRGQELRVVLKVLDPSHHDIALA--FYETASLMSQVSHTHLAFVHGVCVRGP-----E 140 Query: 101 DVYLVTHLMGADLNNIVKCQK--LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV 158 ++ + ++ L+ ++ ++ + + Q+ L Y+ + +++H ++ N+ + Sbjct: 141 NIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILL 200 Query: 159 NEDCE-------LKILD--FGLARHTDDEMTGYVATRWYRAPEIMLNWMHY-NQTVDIWS 208 +K+ D GL + +E + + APE + + + +D W Sbjct: 201 ARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLSTAMDKWG 257 Query: 209 VGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKM 268 G + E+ G L+ S ++ Q ++P+ Sbjct: 258 FGATLLEI-----------------------CFDGEAPLQSRSPSEKEHFYQRQHRLPEP 294 Query: 269 NFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFE 328 + + L + L + +R + L Q H+ D +P + + Sbjct: 295 SCPQLAT--------LTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASD 346 Query: 329 SRDLLIDEWKSL 340 K + Sbjct: 347 PTVFHKRYLKKI 358 >1AD5-A nrPDB Length = 438 Score = 193 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 65/244 (26%), Positives = 112/244 (45%), Gaps = 30/244 (12%) Query: 15 KTIWEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELR 73 K WE+P E + +G+G +G V A K +VAVK + S+ + E Sbjct: 174 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMSV---EAFLAEAN 229 Query: 74 LLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKC---QKLTDDHVQF 129 ++K ++H+ ++ L V T +Y++T M L + +K K + Sbjct: 230 VMKTLQHDKLVKLHAVVTKE-------PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID 282 Query: 130 LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW-- 187 QI G+ +I + IHRDL+ +N+ V+ KI DFGLAR V ++ Sbjct: 283 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLAR---------VGAKFPI 333 Query: 188 -YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAE 245 + APE + N+ + D+WS G ++ E++T GR +PG + + ++ + R P E Sbjct: 334 KWTAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE 392 Query: 246 LLKK 249 + Sbjct: 393 NCPE 396 >3V5Q-A nrPDB Length = 297 Score = 193 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 59/309 (19%), Positives = 106/309 (34%), Gaps = 66/309 (21%) Query: 22 ERYQNLSPVGSGAYGSVCAAF-----DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 +G GA+G V A TK + VAVK L P + K RE LL Sbjct: 15 RDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA--RKDFQREAELLT 72 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK--------------- 121 +++HE+++ V L + + ++ DLN ++ Sbjct: 73 NLQHEHIVKFYGVCGDGDPL-----IMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAK 127 Query: 122 --LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM 179 L + + QI G+ Y+ S +HRDL N V + +KI DFG++R Sbjct: 128 GELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTD 187 Query: 180 TGYVA-----TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLK 233 V + PE ++ + + D+WS G I+ E+ T G+ + + + ++ Sbjct: 188 YYRVGGHTMLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIE 246 Query: 234 LILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDS 293 I + + K D++ + Sbjct: 247 CITQGRVLERPRVCPK------------------------------EVYDVMLGCWQREP 276 Query: 294 DKRITAAQA 302 +R+ + Sbjct: 277 QQRLNIKEI 285 >5AMN-A nrPDB Length = 299 Score = 193 bits (492), Expect = 8e-50, Method: Composition-based stats. Identities = 75/303 (24%), Positives = 119/303 (39%), Gaps = 41/303 (13%) Query: 13 LNKTIWEVPER-YQNLSPVGSGAYGSVCAA-----FDTKTGLRVAVKKLSRPFQSIIHAK 66 L WE P + +G G +G V A VAVK L + S + Sbjct: 13 LEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML-KENASPSELR 71 Query: 67 RTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK----- 121 E +LK + H +VI L + L + +V + L ++ + Sbjct: 72 DLLSEFNVLKQVNHPHVIKLYGACSQDGPL-----LLIVEYAKYGSLRGFLRESRKVGPG 126 Query: 122 ------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT 175 LT + +QI +G++Y+ ++HRDL N+ V E ++KI DFGL+R Sbjct: 127 YPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV 186 Query: 176 DDEMT------GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDH 228 +E + G + +W A E + + + Y D+WS G ++ E++T G +PG Sbjct: 187 YEEDSYVKRSQGRIPVKW-MAIESLFDHI-YTTQSDVWSFGVLLWEIVTLGGNPYPGIPP 244 Query: 229 IDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKM 288 L L E S E R +Q Q P ++ DL EKM Sbjct: 245 ERLFNL---LKTGHRMERPDNCSEEMYRLMLQCWKQEPDKR-----PVFADISKDL-EKM 295 Query: 289 LVL 291 +V Sbjct: 296 MVK 298 >5EG3-A nrPDB Length = 334 Score = 193 bits (491), Expect = 8e-50, Method: Composition-based stats. Identities = 69/256 (26%), Positives = 111/256 (43%), Gaps = 41/256 (16%) Query: 15 KTIWEVP-ERYQNLSPVGSGAYGSVCAA----FDTKTGLR---VAVKKLSRPFQSIIHAK 66 WE P ++ P+G GA+G V A D VAVK L + + Sbjct: 27 DPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKML-KDDATEKDLS 85 Query: 67 RTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK---- 121 E+ ++K + KH+N+I LL T L +V + +L ++ ++ Sbjct: 86 DLVSEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVAYASKGNLREYLRARRPPGM 140 Query: 122 -------------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILD 168 +T + YQ+ RG++Y+ S IHRDL N+ V E+ +KI D Sbjct: 141 ELSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 200 Query: 169 FGLARHTD------DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRT 221 FGLAR + + G + +W APE + + + Y D+WS G +M E+ T G + Sbjct: 201 FGLARDINNIDFFKETTNGRLPVKW-MAPEALFDRV-YTHQSDVWSFGVLMWEIFTLGGS 258 Query: 222 LFPGTDHIDQLKLILR 237 +PG + KL+ Sbjct: 259 PYPGIPVEELFKLLKE 274 >3ORP-A nrPDB Length = 311 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 65/277 (23%), Positives = 118/277 (42%), Gaps = 16/277 (5%) Query: 19 EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSIIHAKRTYRELRLLKH 77 + +RY+ +G G V A D + VAVK L + R RE + Sbjct: 9 HLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAA 68 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQK-LTDDHVQFLIYQIL 135 + H ++ + D T Y+V + L +IV + +T +I Sbjct: 69 LNHPAIVAVYD--TGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADAC 126 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD------EMTGYVATRWYR 189 + L + H IIHRD+KP+N+ ++ +K++DFG+AR D + + T Y Sbjct: 127 QALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYL 186 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 +PE + D++S+GC++ E+LTG F G + +R P + + Sbjct: 187 SPE-QARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEG 245 Query: 250 ISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLE 286 +S++ +++L + P+ N + A + DL+ Sbjct: 246 LSADLDAVVLKALAKNPE----NRYQTAAEMRADLVR 278 >4XUF-A nrPDB Length = 297 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 63/258 (24%), Positives = 111/258 (43%), Gaps = 46/258 (17%) Query: 18 WEVP-ERYQNLSPVGSGAYGSVCAAFD---TKTG--LRVAVKKLSRPFQSIIHAKRTYRE 71 WE P E + +GSGA+G V A +KTG ++VAVK L S + E Sbjct: 4 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS-EREALMSE 62 Query: 72 LRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK--LTDDHVQ 128 L+++ + HEN++ LL T + + + + DL N ++ ++ ++D ++ Sbjct: 63 LKMMTQLGSHENIVNLLGACTLSGPI-----YLIFEYCCYGDLLNYLRSKREKFSEDEIE 117 Query: 129 F----------------------LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKI 166 + YQ+ +G++++ +HRDL N+ V +KI Sbjct: 118 YENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKI 177 Query: 167 LDFGLARHTDDEMTGYV------ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-G 219 DFGLAR + V +W APE + + Y D+WS G ++ E+ + G Sbjct: 178 CDFGLARDIMSDSNYVVRGNARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFSLG 235 Query: 220 RTLFPGTDHIDQLKLILR 237 +PG +++ Sbjct: 236 VNPYPGIPVDANFYKLIQ 253 >3DKO-A nrPDB Length = 318 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 52/236 (22%), Positives = 98/236 (41%), Gaps = 19/236 (8%) Query: 25 QNLSPVGSGAYGSVCAAFDTKTGLR---VAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 + +G+G +G VC+ G R VA+K L + + E ++ H Sbjct: 46 KIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTE-KQRRDFLCEASIMGQFDHP 104 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ--KLTDDHVQFLIYQILRGLK 139 NV+ L V T + + + ++ + L+ ++ + T + ++ I G++ Sbjct: 105 NVVHLEGVVTRGKPV-----MIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMR 159 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVAT------RWYRAPEI 193 Y+ +HRDL N+ VN + K+ DFGL+R +D+ T + APE Sbjct: 160 YLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEA 219 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 + + + D+WS G +M E+++ G + + D +K I P Sbjct: 220 IQ-YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCP 274 >3QGY-A nrPDB Length = 286 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 51/223 (22%), Positives = 98/223 (43%), Gaps = 19/223 (8%) Query: 21 PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH 80 P + +GSG +G V + VA+K + S E ++ + H Sbjct: 26 PSELTFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIKEGSMSEDD---FIEEAEVMMKLSH 81 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK--LTDDHVQFLIYQILRG 137 ++ L V E + LV M L++ ++ Q+ + + + + G Sbjct: 82 PKLVQLYGVCL------EQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEG 135 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-DDEMTGYVATRW---YRAPEI 193 + Y+ A +IHRDL N V E+ +K+ DFG+ R DD+ T T++ + +PE+ Sbjct: 136 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 195 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLI 235 ++ Y+ D+WS G +M E+ + G+ + + + ++ I Sbjct: 196 F-SFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDI 237 >6DBM-A nrPDB Length = 318 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 113/297 (38%), Gaps = 37/297 (12%) Query: 20 VPERY-QNLSPVGSGAYGSVCA-AFDTK---TGLRVAVKKLSRPFQSIIHAKRTYRELRL 74 +RY + + +G G +G V +D TG VAVK L + H +E+ + Sbjct: 28 FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-KADAGPQHRSGWKQEIDI 86 Query: 75 LKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQKLTDDHVQFLIYQ 133 L+ + HE++I A + + LV + L + + + + Q Sbjct: 87 LRTLYHEHIIKYKGCCEDAGA----ASLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQ 142 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV-------ATR 186 I G+ Y+HS IHRDL N+ ++ D +KI DFGLA+ + Y Sbjct: 143 ICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF 202 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 WY APE + + Y D+WS G + ELLT +P + Sbjct: 203 WY-APECLKEYKFY-YASDVWSFGVTLYELLTHC----------------DSSQSPPTKF 244 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGANP-LAVDLLEKMLVLDSDKRITAAQA 302 L+ I + + LT++ + P L++ ++ R T Sbjct: 245 LELIGIAQGQMTVLRLTELLERGERLPRPDKCPAEVYHLMKNCWETEASFRPTFENL 301 >5X02-A nrPDB Length = 347 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 67/277 (24%), Positives = 118/277 (42%), Gaps = 49/277 (17%) Query: 2 SQERPTFY--RQELNKTI-WEVP-ERYQNLSPVGSGAYGSVCAAFD---TKTG--LRVAV 52 S + FY +E + WE P E + +GSGA+G V A +KTG ++VAV Sbjct: 24 SSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAV 83 Query: 53 KKLSRPFQSIIHAKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA 111 K L S + EL+++ + HEN++ LL T + + + + Sbjct: 84 KMLKEKADSS-EREALMSELKMMTQLGSHENIVNLLGACTLSGPI-----YLIFEYCCYG 137 Query: 112 DLNNIVKCQK--LTDDHVQF----------------------LIYQILRGLKYIHSADII 147 DL N ++ ++ ++D +++ YQ+ +G++++ + Sbjct: 138 DLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCV 197 Query: 148 HRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV------ATRWYRAPEIMLNWMHYN 201 HRDL N+ V +KI DFGLAR + V +W APE + + Y Sbjct: 198 HRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKW-MAPESLFEGI-YT 255 Query: 202 QTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILR 237 D+WS G ++ E+ + G +PG +++ Sbjct: 256 IKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQ 292 >6DBN-A nrPDB Length = 316 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 67/302 (22%), Positives = 121/302 (40%), Gaps = 39/302 (12%) Query: 12 ELNKTIWEVPERY-QNLSPVGSGAYGSVCAAFDTK----TGLRVAVKKLSRPFQSIIHAK 66 E++ T +E +R+ + + +G G +G V TG +VAVK L +P H Sbjct: 26 EVDPTHFE--KRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSL-KPESGGNHIA 82 Query: 67 RTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV--KCQKLT 123 +E+ +L+++ HEN++ + T N + L+ + L + K+ Sbjct: 83 DLKKEIEILRNLYHENIVKYKGICTEDG----GNGIKLIMEFLPSGSLKEYLPKNKNKIN 138 Query: 124 DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV 183 QI +G+ Y+ S +HRDL N+ V + ++KI DFGL + + + Y Sbjct: 139 LKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYT 198 Query: 184 -------ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 WY APE ++ Y D+WS G + ELLT + +D + L L Sbjct: 199 VKDDRDSPVFWY-APECLMQSKFY-IASDVWSFGVTLHELLT----YCDSDSS-PMALFL 251 Query: 237 RLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKR 296 +++G + + +L + ++ L+ K R Sbjct: 252 KMIG-------PTHGQMTVTRLVNTLKEGKRLPCP---PNCPDEVYQLMRKCWEFQPSNR 301 Query: 297 IT 298 + Sbjct: 302 TS 303 >4YHJ-A nrPDB Length = 584 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 63/298 (21%), Positives = 115/298 (38%), Gaps = 44/298 (14%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR-TYRELRLLKHMKHEN 82 +++ +G G +G VCA TG A KKL + + E R+L+ ++ Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRF 246 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC---QKLTDDHVQFLIYQILRGLK 139 V+ L + +L ++T + G DL + + F ++ GL+ Sbjct: 247 VVSLAYAYETKDAL-----CLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLE 301 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT--DDEMTGYVATRWYRAPEIMLNW 197 + I++RDLKP N+ +++ ++I D GLA + G V T Y APE+ +N Sbjct: 302 DLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEV-VNN 360 Query: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 Y + D W +GC++ E++ G + F + + + + + E +K Sbjct: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKF------- 413 Query: 258 YIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQALAHAYFAQ 310 + A + +L + KR+ AA H F Sbjct: 414 --------------------SEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKD 451 >1BYG-A nrPDB Length = 278 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 67/311 (21%), Positives = 121/311 (38%), Gaps = 56/311 (18%) Query: 4 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII 63 + FYR + E+ + L +G G +G V G +VAVK + Sbjct: 7 AQDEFYRSGWALNMKEL----KLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDAT--- 57 Query: 64 HAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQK- 121 A+ E ++ ++H N++ LL V +EE +Y+VT M L + ++ + Sbjct: 58 -AQAFLAEASVMTQLRHSNLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGR 111 Query: 122 --LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM 179 L D + + ++Y+ + +HRDL N+ V+ED K+ DFGL + Sbjct: 112 SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ 171 Query: 180 -TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILR 237 TG + +W APE + ++ D+WS G ++ E+ + GR +P D + + + Sbjct: 172 DTGKLPVKW-TAPEAL-REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK 229 Query: 238 LVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI 297 + G P ++++ LD+ R Sbjct: 230 GYKMDAPD------------------------------GCPPAVYEVMKNCWHLDAAMRP 259 Query: 298 TAAQA---LAH 305 + Q L H Sbjct: 260 SFLQLREQLEH 270 >5O0Y-A nrPDB Length = 579 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 79/298 (26%), Positives = 121/298 (40%), Gaps = 53/298 (17%) Query: 35 YGSVCAAFDTKTGLRVAVKK--LSRPFQSIIHA---KRTYRELRLLKHMKHENVIGLLDV 89 + V AFD VAVK L++ ++ K RE R+ K + H ++ L D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 90 FTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL-TDDHVQFLIYQILRGLKYIHSAD--I 146 F SL+ + ++ + G DL+ +K KL ++ + +I QI+ LKY++ I Sbjct: 357 F----SLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPI 412 Query: 147 IHRDLKPSNLAVNED---CELKILDFGLARHTDDEMTGYV----------ATRWYRAPEI 193 IH DLKP N+ + E+KI DFGL++ DD+ V T WY PE Sbjct: 413 IHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPEC 472 Query: 194 MLNWM---HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250 + + VD+WSVG I + L GR F G + Q ++L++ Sbjct: 473 FVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQQ-------------DILQEN 518 Query: 251 SSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 + A Q P P A + + L + RI Q Y Sbjct: 519 TILKATE-----VQFPPK------PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 565 >4XLV-A nrPDB Length = 328 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 63/326 (19%), Positives = 114/326 (34%), Gaps = 68/326 (20%) Query: 15 KTIWEVP-ERYQNLSPVGSGAYGSVCA--AFDTKTGL---RVAVKKLSRPFQSIIHAKRT 68 WEV E+ L +G G++G V A D G RVAVK ++ S+ Sbjct: 31 PDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESA-SLRERIEF 89 Query: 69 YRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVK--------- 118 E ++K +V+ LL V + + +V LM DL + ++ Sbjct: 90 LNEASVMKGFTCHHVVRLLGVVSKGQPT------LVVMELMAHGDLKSYLRSLRPEAENN 143 Query: 119 --CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD 176 T + + +I G+ Y+++ +HRDL N V D +KI DFG+ R Sbjct: 144 PGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIY 203 Query: 177 DEMTGYVATRW-----YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHID 230 + + + APE + + + + + D+WS G ++ E+ + + G + Sbjct: 204 ETDYYRKGGKGLLPVRWMAPESLKDGV-FTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQ 262 Query: 231 QLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLV 290 LK ++ + DL+ Sbjct: 263 VLKFVMDGGYLDQPDNCP------------------------------ERVTDLMRMCWQ 292 Query: 291 LDSDKRITAAQALA------HAYFAQ 310 + + R T + + H F + Sbjct: 293 FNPNMRPTFLEIVNLLKDDLHPSFPE 318 >6GVJ-A nrPDB Length = 429 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 69/312 (22%), Positives = 117/312 (37%), Gaps = 54/312 (17%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-HEN 82 Y L +GSG V + K A+K ++ E+ L ++ H + Sbjct: 146 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 83 -VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGLKY 140 +I L D + +Y+V DLN+ +K +K + + +L + Sbjct: 205 KIIRLYDYEITDQ------YIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 258 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT-----GYVATRWYRAPEIML 195 IH I+H DLKP+N + D LK++DFG+A + T V T Y PE + Sbjct: 259 IHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 317 Query: 196 NWMHYNQ----------TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 + + D+WS+GCI+ + G+T F + I +L Sbjct: 318 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ-----QIINQISKLHAIIDP- 371 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAH 305 N+ +P+ + D+L+ L D +RI+ + LAH Sbjct: 372 -----------NHEIEFPDIPEKDL-----------QDVLKCCLKRDPKQRISIPELLAH 409 Query: 306 AYFAQYHDPDDE 317 Y P ++ Sbjct: 410 PYVQIQTHPVNQ 421 >5KMM-A nrPDB Length = 329 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 59/327 (18%), Positives = 111/327 (33%), Gaps = 69/327 (21%) Query: 4 ERPTFYRQELNKTIWEVPERYQNLS-PVGSGAYGSVCAAFDT-----KTGLRVAVKKLSR 57 E P ++ + + + R L +G GA+G V A + + VAVK L Sbjct: 19 ENPQYFS---DACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE 75 Query: 58 PFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV 117 +S + RE LL ++H++++ V T R L + + ++ DLN + Sbjct: 76 ASESA--RQDFQREAELLTMLQHQHIVRFFGVCTEGRPL-----LMVFEYMRHGDLNRFL 128 Query: 118 KCQK----------------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNED 161 + L + + Q+ G+ Y+ +HRDL N V + Sbjct: 129 RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG 188 Query: 162 CELKILDFGLARHTDDEMTGYVATR-----WYRAPEIMLNWMHYNQTVDIWSVGCIMAEL 216 +KI DFG++R V R + PE +L + + D+WS G ++ E+ Sbjct: 189 LVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESIL-YRKFTTESDVWSFGVVLWEI 247 Query: 217 LT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFI 275 T G+ + + + + I + Sbjct: 248 FTYGKQPWYQLSNTEAIDCITQGRELERPRACP--------------------------- 280 Query: 276 GANPLAVDLLEKMLVLDSDKRITAAQA 302 P ++ + +R + Sbjct: 281 ---PEVYAIMRGCWQREPQQRHSIKDV 304 >4LFI-A nrPDB Length = 374 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 81/336 (24%), Positives = 155/336 (46%), Gaps = 49/336 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAV------------------------KK--- 54 + Y+ + VG G Y V + +++ + K Sbjct: 40 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 99 Query: 55 ---LSRPFQSIIHAKRTYRELR----LLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTH 107 + + + +R H H N+I L D+ S LV Sbjct: 100 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA----LVFE 155 Query: 108 LMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKI 166 + +++ + KLTD ++F ++++L+ L Y HS I+HRD+KP N+ ++ ++ +L++ Sbjct: 156 YVD-NVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRL 214 Query: 167 LDFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTL-F 223 +D+GLA H + E VA+R+++ PE+++++ Y+ ++D+WS G ++A ++ R F Sbjct: 215 IDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF 274 Query: 224 PGTDHIDQLKLILRLVGTPGAE-LLKKISSESARNYIQSLTQMPKM-----NFANVFIGA 277 GT + DQL I++++GT E L K R + + K N N + Sbjct: 275 HGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSG 334 Query: 278 NPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHD 313 N +DL++ +L D +R+TA +A+ H +FA + Sbjct: 335 NDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 370 >5U6B-A nrPDB Length = 307 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 57/296 (19%), Positives = 109/296 (36%), Gaps = 47/296 (15%) Query: 26 NLSPVGSGAYGSVCAAFDTKTG--LRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 +G G +G+V + L+VAVK + + + E +K H NV Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNV 86 Query: 84 IGLLDVFTPARSLEEFN-DVYLVTHLMGADLNNIVKCQKLTDDHV-------QFLIYQIL 135 + L+ V E F V ++ + DL++ + +L D V + I Sbjct: 87 MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW-----YRA 190 G++Y+ + IHRDL N +NE+ + + DFGL++ + + A Sbjct: 147 SGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIA 206 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 E + + + Y D+WS G M E+ T G+T +PG ++ + Sbjct: 207 IESLADRV-YTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIY----------------- 248 Query: 250 ISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAH 305 +Y++ ++ + L+ + L+ R + + Sbjct: 249 -------DYLRQGNRLKQP------ADCLDGLYALMSRCWELNPQDRPSFTELRED 291 >3QUP-A nrPDB Length = 323 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 59/297 (19%), Positives = 108/297 (36%), Gaps = 49/297 (16%) Query: 20 VPER-YQNLSPVGSGAYGSVCAAFDTKTG---LRVAVKKLSRPFQSIIHAKRTYRELRLL 75 +PE+ + +G G +GSV A + ++VAVK L + + RE + Sbjct: 20 IPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACM 79 Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK-------LTDDHV 127 K H +V L+ V +R+ ++ M DL+ + + L + Sbjct: 80 KEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTL 139 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW 187 + I G++Y+ S + IHRDL N + ED + + DFGL+R Sbjct: 140 VRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCAS 199 Query: 188 -----YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGT 241 + A E + + + Y D+W+ G M E++T G+T + G ++ + ++ Sbjct: 200 KLPVKWLALESLADNL-YTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLI----- 253 Query: 242 PGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT 298 N DL+ + D +R + Sbjct: 254 -------------------------GGNRLKQPPECMEEVYDLMYQCWSADPKQRPS 285 >2W1I-A nrPDB Length = 326 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 73/319 (22%), Positives = 128/319 (40%), Gaps = 45/319 (14%) Query: 6 PTFYRQELNKTIWE------VPER-YQNLSPVGSGAYGSVCAAFDTK----TGLRVAVKK 54 Y Q + +E ER + L +G G +GSV TG VAVKK Sbjct: 18 ENLYFQGAMGSAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKK 77 Query: 55 LSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLN 114 L + H + RE+ +LK ++H+N++ V A N ++ +L L Sbjct: 78 LQHSTEE--HLRDFEREIEILKSLQHDNIVKYKGVCYSAGR---RNLKLIMEYLPYGSLR 132 Query: 115 NIVKCQKLTDDHVQF--LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA 172 + ++ K DH++ QI +G++Y+ + IHRDL N+ V + +KI DFGL Sbjct: 133 DYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLT 192 Query: 173 RHTDDEMTGYV-------ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPG 225 + + Y WY APE + ++ D+WS G ++ EL T Sbjct: 193 KVLPQDKEYYKVKEPGESPIFWY-APESL-TESKFSVASDVWSFGVVLYELFT------- 243 Query: 226 TDHIDQLKLILRLVGTPGAELLKKISSESARN-YIQSLTQMPKMNFANVFIGANPLAVDL 284 + +P AE ++ I ++ + L ++ K N P + + Sbjct: 244 ---------YIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYM 294 Query: 285 L-EKMLVLDSDKRITAAQA 302 + + + ++R + Sbjct: 295 IMTECWNNNVNQRPSFRDL 313 >3KUL-B nrPDB Length = 325 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 63/278 (22%), Positives = 102/278 (36%), Gaps = 44/278 (15%) Query: 2 SQERPTFYRQE--------LNKTIWEVP-------------ERYQNLSPVGSGAYGSVCA 40 S R Y Q +E P R +GSG G VC Sbjct: 8 SSGRENLYFQGKLPEPQFYAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCY 67 Query: 41 AFDTKTGLR---VAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLE 97 G R VA+K L + + E ++ H N+I L V T R Sbjct: 68 GRLRVPGQRDVPVAIKALKAGYTE-RQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRL-- 124 Query: 98 EFNDVYLVTHLM-GADLNNIVKCQ--KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPS 154 +VT M L+ ++ + T + ++ + G++Y+ +HRDL Sbjct: 125 ----AMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAAR 180 Query: 155 NLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYRAPEIMLNWMHYNQTVDIW 207 N+ V+ + K+ DFGL+R +D+ G + RW APE + + ++ D+W Sbjct: 181 NVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRW-TAPEAIA-FRTFSSASDVW 238 Query: 208 SVGCIMAE-LLTGRTLFPGTDHIDQLKLILRLVGTPGA 244 S G +M E L G + + D + + P Sbjct: 239 SFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAP 276 >4R7H-A nrPDB Length = 343 Score = 188 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 59/253 (23%), Positives = 101/253 (39%), Gaps = 46/253 (18%) Query: 11 QELNKTIWEVPER-YQNLSPVGSGAYGSVCAAFDTKTGLR-----VAVKKLSRPFQSIIH 64 Q WE P Q +G+GA+G V A G VAVK L + Sbjct: 38 QLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHADE 96 Query: 65 AKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC---- 119 + EL+++ H+ +HEN++ LL T + + + + DL N ++ Sbjct: 97 KEALMSELKIMSHLGQHENIVNLLGACTHGGPV-----LVITEYCTYGDLLNFLRRKAEA 151 Query: 120 --------------------QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN 159 + L + Q+ +G+ ++ S + IHRD+ N+ + Sbjct: 152 MLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLT 211 Query: 160 EDCELKILDFGLARHTDDEM------TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIM 213 KI DFGLAR ++ + +W APE + + + Y D+WS G ++ Sbjct: 212 NGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKW-MAPESIFDSV-YTVQSDVWSYGILL 269 Query: 214 AELLT-GRTLFPG 225 E+ + G +PG Sbjct: 270 WEIFSLGLNPYPG 282 >5AP3-A nrPDB Length = 313 Score = 188 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 71/332 (21%), Positives = 120/332 (36%), Gaps = 58/332 (17%) Query: 4 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII 63 Y Q ++ Y L +GSG V + K A+K ++ Sbjct: 14 GTENLYFQSMSVK----GRIYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQ 68 Query: 64 HAKRTYRELRLLKHMK-HEN-VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 E+ L ++ H + +I L D + +Y+V DLN +K +K Sbjct: 69 TLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQ------YIYMVMECGNIDLNGWLKKKK 122 Query: 122 -LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180 + + +L + IH I+H DLKP+N + D LK++DFG+A + T Sbjct: 123 SIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTT 181 Query: 181 -----GYVATRWYRAPEIMLNWMHYNQ----------TVDIWSVGCIMAELLTGRTLFPG 225 V T Y PE + + + D+WS+GCI+ + G+T F Sbjct: 182 SVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ- 240 Query: 226 TDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLL 285 + I +L N+ +P+ + D+L Sbjct: 241 ----QIINQISKLHAIIDP------------NHEIEFPDIPEKDL-----------QDVL 273 Query: 286 EKMLVLDSDKRITAAQALAHAYFAQYHDPDDE 317 + L D +RI+ + LAH Y P ++ Sbjct: 274 KCCLKRDPKQRISIPELLAHPYVQIQTHPVNQ 305 >5FM2-A nrPDB Length = 355 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 75/317 (23%), Positives = 119/317 (37%), Gaps = 55/317 (17%) Query: 13 LNKTIWEVPER-YQNLSPVGSGAYGSVCAA-----FDTKTGLRVAVKKLSRPFQSIIHAK 66 L WE P + +G G +G V A VAVK L + S + Sbjct: 54 LEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML-KENASPSELR 112 Query: 67 RTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK----- 121 E +LK + H +VI L + L + +V + L ++ + Sbjct: 113 DLLSEFNVLKQVNHPHVIKLYGACSQDGPL-----LLIVEYAKYGSLRGFLRESRKVGPG 167 Query: 122 --------------------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNED 161 LT + +QI +G++Y+ ++HRDL N+ V E Sbjct: 168 YLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEG 227 Query: 162 CELKILDFGLARHTDDEMT------GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAE 215 ++KI DFGL+R +E + G + +W A E + + + Y D+WS G ++ E Sbjct: 228 RKMKISDFGLSRDVYEEDSYVKRSQGRIPVKW-MAIESLFDHI-YTTQSDVWSFGVLLWE 285 Query: 216 LLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVF 274 ++T G +PG L L E S E R +Q Q P Sbjct: 286 IVTLGGNPYPGIPPERLFNL---LKTGHRMERPDNCSEEMYRLMLQCWKQEPDKR----- 337 Query: 275 IGANPLAVDLLEKMLVL 291 ++ DL EKM+V Sbjct: 338 PVFADISKDL-EKMMVK 353 >2WTK-B nrPDB Length = 373 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 68/337 (20%), Positives = 126/337 (37%), Gaps = 44/337 (13%) Query: 24 YQNLSPVGSGAYG--SVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 Y+ L+ +G G +V A TG V V++++ S EL + K H Sbjct: 11 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 70 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQ---KLTDDHVQFLIYQILRG 137 N++ F N++++VT M +++ + + + +++ +L+ Sbjct: 71 NIVPYRATFIAD------NELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKA 124 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKI---------LDFGLARHTDDEMTGY-VATRW 187 L YIH +HR +K S++ ++ D ++ + + G + + Y V Sbjct: 125 LDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLP 184 Query: 188 YRAPEIM-LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQL--------KLILRL 238 + +PE++ N Y+ DI+SVG EL G F L +L Sbjct: 185 WLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDT 244 Query: 239 VGTPGAELLKKISSESARNYI----------QSLTQMPKMNFANVFIGANPLAVDLLEKM 288 P EL S A + + S P + F +P +E+ Sbjct: 245 STIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTF---SPHFHHFVEQC 301 Query: 289 LVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQ 325 L + D R +A+ L H++F Q E + + Sbjct: 302 LQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRP 338 >5TUR-A nrPDB Length = 404 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 60/314 (19%), Positives = 117/314 (37%), Gaps = 50/314 (15%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP----FQSIIHAKRTYRELRLLKHM 78 +YQ +GSG +GSV + L VA+K + + + + + R E+ LLK + Sbjct: 128 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 187 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA--DLNNIV-KCQKLTDDHVQFLIYQIL 135 G V E + L+ DL + + + L ++ + +Q+L Sbjct: 188 SS----GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 243 Query: 136 RGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLARHTDDE-MTGYVATRWYRAPEI 193 +++ H+ ++HRD+K N+ ++ ELK++DFG D T + TR Y PE Sbjct: 244 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEW 303 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 + ++ ++ +WS+G ++ +++ G F + I + ++ R Sbjct: 304 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR---------------- 347 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHD 313 + L+ L L R T + H + Sbjct: 348 ---------------------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLL 386 Query: 314 PDDEPVADPYDQSF 327 P + + S Sbjct: 387 PQETAEIHLHSLSP 400 >1FVR-A nrPDB Length = 327 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 68/319 (21%), Positives = 122/319 (38%), Gaps = 66/319 (20%) Query: 12 ELNKTIWEVPE--RYQNLSPVGSGAYGSVCAAFDTKTGLRV--AVKKLSRPFQSIIHAKR 67 + TI+ V + + +G G +G V A K GLR+ A+K++ + + S + Sbjct: 13 NPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRM-KEYASKDDHRD 71 Query: 68 TYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYL-VTHLMGADLNNIVKCQK---- 121 EL +L + H N+I LL E +YL + + +L + ++ + Sbjct: 72 FAGELEVLCKLGHHPNIINLLGAC------EHRGYLYLAIEYAPHGNLLDFLRKSRVLET 125 Query: 122 -------------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILD 168 L+ + + RG+ Y+ IHRDL N+ V E+ KI D Sbjct: 126 DPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIAD 185 Query: 169 FGLARHTD---DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFP 224 FGL+R + + G + RW A E + N+ Y D+WS G ++ E+++ G T + Sbjct: 186 FGLSRGQEVYVKKTMGRLPVRW-MAIESL-NYSVYTTNSDVWSYGVLLWEIVSLGGTPYC 243 Query: 225 GTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDL 284 G + + + P+ + + DL Sbjct: 244 GMTCAELYEKL------------------------------PQGYRLEKPLNCDDEVYDL 273 Query: 285 LEKMLVLDSDKRITAAQAL 303 + + +R + AQ L Sbjct: 274 MRQCWREKPYERPSFAQIL 292 >3BGP-A nrPDB Length = 333 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 60/314 (19%), Positives = 117/314 (37%), Gaps = 50/314 (15%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP----FQSIIHAKRTYRELRLLKHM 78 +YQ +GSG +GSV + L VA+K + + + + + R E+ LLK + Sbjct: 57 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 116 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA--DLNNIV-KCQKLTDDHVQFLIYQIL 135 G V E + L+ DL + + + L ++ + +Q+L Sbjct: 117 SS----GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 172 Query: 136 RGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLARHTDDE-MTGYVATRWYRAPEI 193 +++ H+ ++HRD+K N+ ++ ELK++DFG D T + TR Y PE Sbjct: 173 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEW 232 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 + ++ ++ +WS+G ++ +++ G F + I + ++ R Sbjct: 233 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR---------------- 276 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHD 313 + L+ L L R T + H + Sbjct: 277 ---------------------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLL 315 Query: 314 PDDEPVADPYDQSF 327 P + + S Sbjct: 316 PQETAEIHLHSLSP 329 >3HMP-A nrPDB Length = 342 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 69/312 (22%), Positives = 117/312 (37%), Gaps = 54/312 (17%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-HEN 82 Y L +GSG V + K A+K ++ E+ L ++ H + Sbjct: 58 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 83 -VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGLKY 140 +I L D + +Y+V DLN+ +K +K + + +L + Sbjct: 117 KIIRLYDYEITDQ------YIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 170 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT-----GYVATRWYRAPEIML 195 IH I+H DLKP+N + D LK++DFG+A + T V T Y PE + Sbjct: 171 IHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 229 Query: 196 NWMHYNQ----------TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 + + D+WS+GCI+ + G+T F + I +L Sbjct: 230 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ-----QIINQISKLHAIIDP- 283 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAH 305 N+ +P+ + D+L+ L D +RI+ + LAH Sbjct: 284 -----------NHEIEFPDIPEKDL-----------QDVLKCCLKRDPKQRISIPELLAH 321 Query: 306 AYFAQYHDPDDE 317 Y P ++ Sbjct: 322 PYVQIQTHPVNQ 333 >5VD3-A nrPDB Length = 311 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 108/296 (36%), Gaps = 45/296 (15%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM- 78 + +Q LS +G G+YG V + G AVK+ PF+ R E+ + + Sbjct: 55 FQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVG 114 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC--QKLTDDHVQFLIYQILR 136 +H + L ++ EE +YL T L G L + L + V + L Sbjct: 115 QHPCCVRL------EQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLL 168 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV--ATRWYRAPEIM 194 L ++HS ++H D+KP+N+ + K+ DFGL G V Y APE++ Sbjct: 169 ALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELL 228 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 254 Y D++S+G + E+ L G + QL+ G E Sbjct: 229 QG--SYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQ-----GYLPPEFT------- 274 Query: 255 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 G + +L ML D R TA LA Q Sbjct: 275 --------------------AGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQ 310 >4PDO-A nrPDB Length = 299 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 50/235 (21%), Positives = 100/235 (42%), Gaps = 20/235 (8%) Query: 28 SPVGSGAYGSVCAA-FDTKTGLR---VAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 +G+G +G V T +G + VA+K L + E ++ H N+ Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRV-DFLGEAGIMGQFSHHNI 98 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ--KLTDDHVQFLIYQILRGLKYI 141 I L V + + + + + ++ L+ ++ + + + + ++ I G+KY+ Sbjct: 99 IRLEGVISKYKPM-----MIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYL 153 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW------YRAPEIML 195 + + +HRDL N+ VN + K+ DFGL+R +D+ T + APE + Sbjct: 154 ANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAI- 212 Query: 196 NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 ++ + D+WS G +M E++T G + + + +K I P Sbjct: 213 SYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPS 267 >1LUF-A nrPDB Length = 343 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 56/268 (20%), Positives = 97/268 (36%), Gaps = 46/268 (17%) Query: 19 EVPER-YQNLSPVGSGAYGSVCAAFDT-----KTGLRVAVKKLSRPFQSIIHAKRTYREL 72 E P + + +G GA+G V A + VAVK L + + A RE Sbjct: 43 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQA-DFQREA 101 Query: 73 RLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC------------- 119 L+ + N++ LL V + + L ++ DLN ++ Sbjct: 102 ALMAEFDNPNIVKLLGVCAVGKPM-----CLLFEYMAYGDLNEFLRSMSPHTVCSLSHSD 156 Query: 120 ------------QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKIL 167 L+ + Q+ G+ Y+ +HRDL N V E+ +KI Sbjct: 157 LSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIA 216 Query: 168 DFGLAR------HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GR 220 DFGL+R + + + RW PE + + Y D+W+ G ++ E+ + G Sbjct: 217 DFGLSRNIYSADYYKADGNDAIPIRW-MPPESIF-YNRYTTESDVWAYGVVLWEIFSYGL 274 Query: 221 TLFPGTDHIDQLKLILRLVGTPGAELLK 248 + G H + + + E Sbjct: 275 QPYYGMAHEEVIYYVRDGNILACPENCP 302 >4E20-A nrPDB Length = 290 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 60/291 (20%), Positives = 111/291 (38%), Gaps = 33/291 (11%) Query: 20 VPERY-QNLSPVGSGAYGSVCA-AFDTK---TGLRVAVKKLSRPFQSIIHAKRTYRELRL 74 +RY + + +G G +G V +D TG VAVK L + + RE+ + Sbjct: 5 FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSG-WQREIEI 63 Query: 75 LKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQI 134 L+ + HE+++ E + ++ ++ L + + + + QI Sbjct: 64 LRTLYHEHIVKYKGCCEDQG---EKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQI 120 Query: 135 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV-------ATRW 187 G+ Y+H+ IHR L N+ ++ D +KI DFGLA+ + Y W Sbjct: 121 CEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFW 180 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247 Y APE + Y D+WS G + ELLT + L+G Sbjct: 181 Y-APECLKECKFY-YASDVWSFGVTLYELLT-----YCDSNQSPHTKFTELIG----HTQ 229 Query: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT 298 +++ ++ ++P+ + L++ ++ R T Sbjct: 230 GQMTVLRLTELLERGERLPRPD------RCPCEIYHLMKNCWETEASFRPT 274 >3SXS-A nrPDB Length = 268 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 55/267 (20%), Positives = 108/267 (40%), Gaps = 20/267 (7%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E L +GSG +G V VAVK + + + ++E + + + H Sbjct: 8 EEITLLKELGSGQFGVVKLGKWKG-QYDVAVKMIK---EGSMSEDEFFQEAQTMMKLSHP 63 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHL-MGADLNNIVKCQK--LTDDHVQFLIYQILRGL 138 ++ V + +Y+VT L N ++ L + + Y + G+ Sbjct: 64 KLVKFYGVCSKEYP------IYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGM 117 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-DDEMTGYVATRW---YRAPEIM 194 ++ S IHRDL N V+ D +K+ DFG+ R+ DD+ V T++ + APE+ Sbjct: 118 AFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVF 177 Query: 195 LNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 ++ Y+ D+W+ G +M E+ + G+ + + + + + + L + Sbjct: 178 -HYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQ 236 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPL 280 + L + + F + PL Sbjct: 237 IMYSCWHELPE-KRPTFQQLLSSIEPL 262 >4YFF-A nrPDB Length = 311 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 53/209 (25%), Positives = 90/209 (43%), Gaps = 17/209 (8%) Query: 25 QNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLS-RPFQSIIHAKRTYRELRLLKHMKHENV 83 + +GSG++G V VA+K+ + S RE+ +L + H V Sbjct: 45 EFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCV 102 Query: 84 IGLLDVFTPARSLEEFNDVYLVT-HLMGADLNNIVKCQK--LTDDHVQFLIYQILRGLKY 140 I + L + + +VT ++ G L +++ QK L + + +G++Y Sbjct: 103 IQFVGAC-----LNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEY 157 Query: 141 IHS--ADIIHRDLKPSNLAVNEDCELKILDFGLARHT----DDEMTGYVATRWYRAPEIM 194 +H+ IIHRDL N+ + ED + DFG +R +D MT + APE+ Sbjct: 158 LHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVF 217 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTLF 223 Y D++S + E+LTG F Sbjct: 218 TQCTRYTIKADVFSYALCLWEILTGEIPF 246 >5HLW-A nrPDB Length = 299 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 59/272 (21%), Positives = 110/272 (40%), Gaps = 22/272 (8%) Query: 28 SPVGSGAYGSVCAAF---DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVI 84 +G G +G V + + AVK L+R I + E ++K H NV+ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDFSHPNVL 84 Query: 85 GLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK--LTDDHVQFLIYQILRGLKYIH 142 LL + + E + + ++ ++ DL N ++ + T + Q+ +G+KY+ Sbjct: 85 SLLGICLRS----EGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLA 140 Query: 143 SADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD--------EMTGYVATRWYRAPEIM 194 S +HRDL N ++E +K+ DFGLAR D + + +W A E + Sbjct: 141 SKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKW-MALESL 199 Query: 195 LNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 + D+WS G ++ EL+T G +P + D +L+ E E Sbjct: 200 QT-QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYE 258 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLL 285 +M + +F+ + + + + Sbjct: 259 VMLKCWHPKAEM-RPSFSELVSRISAIFSTFI 289 >4RC3-A nrPDB Length = 289 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 60/314 (19%), Positives = 117/314 (37%), Gaps = 50/314 (15%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP----FQSIIHAKRTYRELRLLKHM 78 +YQ +GSG +GSV + L VA+K + + + + + R E+ LLK + Sbjct: 13 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 72 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA--DLNNIV-KCQKLTDDHVQFLIYQIL 135 G V E + L+ DL + + + L ++ + +Q+L Sbjct: 73 SS----GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 128 Query: 136 RGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLARHTDDE-MTGYVATRWYRAPEI 193 +++ H+ ++HRD+K N+ ++ ELK++DFG D T + TR Y PE Sbjct: 129 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEW 188 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 + ++ ++ +WS+G ++ +++ G F + I + ++ R Sbjct: 189 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR---------------- 232 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHD 313 + L+ L L R T + H + Sbjct: 233 ---------------------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLL 271 Query: 314 PDDEPVADPYDQSF 327 P + + S Sbjct: 272 PQETAEIHLHSLSP 285 >4H1J-A nrPDB Length = 293 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 52/282 (18%), Positives = 113/282 (40%), Gaps = 52/282 (18%) Query: 28 SPVGSGAYGSVCAAF---DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVI 84 +G G +G V + VAVK + ++ + ++ E ++K++ H +++ Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDC-TLDNKEKFMSEAVIMKNLDHPHIV 88 Query: 85 GLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIY--QILRGLKYI 141 L+ + E +++ L +L + ++ K + + ++Y QI + + Y+ Sbjct: 89 KLIGII-------EEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL 141 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-----MTGYVATRWYRAPEIMLN 196 S + +HRD+ N+ V +K+ DFGL+R+ +DE + +W +PE + N Sbjct: 142 ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKW-MSPESI-N 199 Query: 197 WMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255 + + D+W M E+L+ G+ F ++ D + ++ + P +L Sbjct: 200 FRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCP------- 252 Query: 256 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI 297 P+ L+ + D R Sbjct: 253 -----------------------PVLYTLMTRCWDYDPSDRP 271 >6B2Q-A nrPDB Length = 317 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 65/211 (30%), Positives = 104/211 (49%), Gaps = 9/211 (4%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH-AKRTYRELRLLKHMKHE 81 RY+ + +G G V A D + G RVAVK L F S +R E R + H Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 92 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGAD-LNNIVKC-QKLTDDHVQFLIYQILRGLK 139 + + D + ++ E YLV L+ + LN+++K +L+ H ++ Q R L+ Sbjct: 93 GIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 151 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD---EMTGYV-ATRWYRAPEIML 195 H+A ++HRD+KP N+ + ++KI DFG+A+ D TG V T Y APE L Sbjct: 152 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 211 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGT 226 + D++S+G + E ++G+ F G Sbjct: 212 GHDA-SPASDVYSLGVVGYEAVSGKRPFAGD 241 >4X3F-A nrPDB Length = 337 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 65/211 (30%), Positives = 104/211 (49%), Gaps = 9/211 (4%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH-AKRTYRELRLLKHMKHE 81 RY+ + +G G V A D + G RVAVK L F S +R E R + H Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 72 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGAD-LNNIVKC-QKLTDDHVQFLIYQILRGLK 139 + + D + ++ E YLV L+ + LN+++K +L+ H ++ Q R L+ Sbjct: 73 GIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 131 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD---EMTGYV-ATRWYRAPEIML 195 H+A ++HRD+KP N+ + ++KI DFG+A+ D TG V T Y APE L Sbjct: 132 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 191 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGT 226 + D++S+G + E ++G+ F G Sbjct: 192 GHDA-SPASDVYSLGVVGYEAVSGKRPFAGD 221 >4OW8-A nrPDB Length = 283 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 65/211 (30%), Positives = 104/211 (49%), Gaps = 9/211 (4%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH-AKRTYRELRLLKHMKHE 81 RY+ + +G G V A D + G RVAVK L F S +R E R + H Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 71 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGAD-LNNIVKC-QKLTDDHVQFLIYQILRGLK 139 + + D + ++ E YLV L+ + LN+++K +L+ H ++ Q R L+ Sbjct: 72 GIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 130 Query: 140 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD---EMTGYV-ATRWYRAPEIML 195 H+A ++HRD+KP N+ + ++KI DFG+A+ D TG V T Y APE L Sbjct: 131 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 190 Query: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGT 226 + D++S+G + E ++G+ F G Sbjct: 191 GHDA-SPASDVYSLGVVGYEAVSGKRPFAGD 220 >4X7Q-B nrPDB Length = 312 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 61/312 (19%), Positives = 114/312 (36%), Gaps = 58/312 (18%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP----FQSIIHAKRTYRELRLLKHM 78 Y+ +G G +G+V A L+VA+K + R + + + E+ LL + Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 79 K----HENVIGLLDVFTPARSLEEFNDVYLVTH--LMGADLNNIV-KCQKLTDDHVQFLI 131 H VI LLD F LV L DL + + + L + + Sbjct: 92 GAGGGHPGVIRLLDWFETQEGF------MLVLERPLPAQDLFDYITEKGPLGEGPSRCFF 145 Query: 132 YQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLARHTDDE-MTGYVATRWYR 189 Q++ +++ HS ++HRD+K N+ ++ K++DFG DE T + TR Y Sbjct: 146 GQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYS 205 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 PE + ++ +WS+G ++ +++ G F Sbjct: 206 PPEWISRHQYHALPATVWSLGILLYDMVCGDIPF-------------------------- 239 Query: 250 ISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFA 309 E + +++ P +P L+ + L R + + L + Sbjct: 240 ---ERDQEILEAELHFP--------AHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQ 288 Query: 310 QYHDPDDEPVAD 321 +D P+ Sbjct: 289 --TPAEDVPLNP 298 >4C59-A nrPDB Length = 340 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 64/327 (19%), Positives = 119/327 (36%), Gaps = 63/327 (19%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 + R + E+ R + + G + V A D +G A+K+L + Sbjct: 9 ASGRDQSDFVGQTVELGEL--RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEE 66 Query: 62 IIHAKRTYRELRLLKHMK-HENVIGLLDVFTPARSLEEFN--DVYLVTHLMGADLNNIVK 118 A +E+ +K + H N++ + + + + L+T L L +K Sbjct: 67 KNRA--IIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLK 124 Query: 119 ----CQKLTDDHVQFLIYQILRGLKYIHSAD--IIHRDLKPSNLAVNEDCELKILDFGLA 172 L+ D V + YQ R ++++H IIHRDLK NL ++ +K+ DFG A Sbjct: 125 KMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSA 184 Query: 173 ---------------RHTDDEMTGYVATRWYRAPEIMLNWMHY--NQTVDIWSVGCIMAE 215 R +E T YR PEI+ + ++ + DIW++GCI+ Sbjct: 185 TTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYL 244 Query: 216 LLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFI 275 L + F + + +P + Sbjct: 245 LCFRQHPFED---------------------------GAKLRIVNGKYSIPPHD------ 271 Query: 276 GANPLAVDLLEKMLVLDSDKRITAAQA 302 + L+ ML ++ ++R++ A+ Sbjct: 272 TQYTVFHSLIRAMLQVNPEERLSIAEV 298 >5HVK-A nrPDB Length = 315 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 66/308 (21%), Positives = 117/308 (37%), Gaps = 57/308 (18%) Query: 21 PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH 80 P + +G G +G +TG + +K+L R + + +E+++++ ++H Sbjct: 13 PSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEET--QRTFLKEVKVMRCLEH 70 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC--QKLTDDHVQFLIYQILRGL 138 NV+ + V + L ++ ++ G L I+K + I G+ Sbjct: 71 PNVLKFIGVLYKDKRLN-----FITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGM 125 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT-----------------G 181 Y+HS +IIHR+L N V E+ + + DFGLAR DE T Sbjct: 126 AYLHSMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYT 185 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGT 241 V ++ APE M+N Y++ VD++S G ++ E+ I R+ Sbjct: 186 VVGNPYWMAPE-MINGRSYDEKVDVFSFGIVLCEI------------------IGRVNAD 226 Query: 242 PGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQ 301 P + R ++ N F DL D +KR + + Sbjct: 227 PDYLPRTMDFGLNVRGFLDRYC---PPNCPPSFFPITVRCCDL-------DPEKRPSFVK 276 Query: 302 ALAHAYFA 309 L H + Sbjct: 277 -LEH-WLE 282 >3C1X-A nrPDB Length = 373 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 57/272 (20%), Positives = 110/272 (40%), Gaps = 22/272 (8%) Query: 28 SPVGSGAYGSVCAAF---DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVI 84 +G G +G V + + AVK L+R I + E ++K H NV+ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDFSHPNVL 153 Query: 85 GLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK--LTDDHVQFLIYQILRGLKYIH 142 LL + + E + + ++ ++ DL N ++ + T + Q+ +G+K++ Sbjct: 154 SLLGICLRS----EGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLA 209 Query: 143 SADIIHRDLKPSNLAVNEDCELKILDFGLARH--------TDDEMTGYVATRWYRAPEIM 194 S +HRDL N ++E +K+ DFGLAR ++ + +W A E + Sbjct: 210 SKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKW-MALESL 268 Query: 195 LNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 + D+WS G ++ EL+T G +P + D +L+ E E Sbjct: 269 QT-QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYE 327 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLL 285 +M + +F+ + + + + Sbjct: 328 VMLKCWHPKAEM-RPSFSELVSRISAIFSTFI 358 >3ZBF-A nrPDB Length = 322 Score = 185 bits (469), Expect = 4e-47, Method: Composition-based stats. Identities = 72/321 (22%), Positives = 118/321 (36%), Gaps = 67/321 (20%) Query: 6 PTFYRQELNKTIWEVPERYQNLSPV-GSGAYGSVCAAFDTK-----TGL-RVAVKKLSRP 58 Y Q + + P L + GSGA+G V +G +VAVK L + Sbjct: 16 ENLYFQGSIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKG 75 Query: 59 FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIV 117 + +E L+ H N++ L V Y++ LM G DL + Sbjct: 76 STDQEKIE-FLKEAHLMSKFNHPNILKQLGVCLLNEPQ------YIILELMEGGDLLTYL 128 Query: 118 KCQKL--------TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE-----L 164 + ++ T + L I +G Y+ IHRDL N V+ + Sbjct: 129 RKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIV 188 Query: 165 KILDFGLAR------HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 218 KI DFGLAR + G + RW APE +++ + + D+WS G ++ E+LT Sbjct: 189 KIGDFGLARDIYKNDYYRKRGEGLLPVRW-MAPESLMDGI-FTTQSDVWSFGILIWEILT 246 Query: 219 -GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGA 277 G +P ++D L NY+Q+ ++ Sbjct: 247 LGHQPYPAHSNLDVL------------------------NYVQTGGRLEPPR------NC 276 Query: 278 NPLAVDLLEKMLVLDSDKRIT 298 +L+ + + D+R T Sbjct: 277 PDDLWNLMTQCWAQEPDQRPT 297 >4Y83-A nrPDB Length = 332 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 63/309 (20%), Positives = 124/309 (40%), Gaps = 46/309 (14%) Query: 6 PTFYRQELNKTIWEVPERYQNLSPVG-----SGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60 P R +++ + +P + +G GA+G V A D KT R+A K + Sbjct: 53 PQNGRYQIDSDVLLIPWKL-TYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQF 111 Query: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120 + + +HEN+ L E +++ G+ L + C Sbjct: 112 KPSD-------VEIQACFRHENIAELYGAVL----WGETVHLFMEAGEGGSVLEKLESCG 160 Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM- 179 + + + ++ +L+GL ++HS +IH D+KPSN+ V + ++DFGL+ +++ Sbjct: 161 PMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNI-VFMSTKAVLVDFGLSVQMTEDVY 219 Query: 180 --TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 T Y +PE++L H + DI+S+G + + TG + Sbjct: 220 FPKDLRGTEIYMSPEVILCRGH-STKADIYSLGATLIHMQTGTPPW-------------- 264 Query: 238 LVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI 297 +K+ + +Y+ + + ++ +P +L+E L + + R Sbjct: 265 ---------VKRYPRSAYPSYLYIIHKQAP-PLEDIADDCSPGMRELIEASLERNPNHRP 314 Query: 298 TAAQALAHA 306 AA L H Sbjct: 315 RAADLLKHE 323 >3M42-A nrPDB Length = 299 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 66/328 (20%), Positives = 123/328 (37%), Gaps = 68/328 (20%) Query: 20 VPERYQNLS-PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 + + Y+ S +G G G V F+ +T + A+K L + RE+ L Sbjct: 15 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRA 67 Query: 79 -KHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK---LTDDHVQFLIYQ 133 + +++ ++DV+ + + +V + G +L + ++ + T+ ++ Sbjct: 68 SQCPHIVRIVDVYENLYAGR--KCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 125 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVNE---DCELKILDFGLARHTDDEMTGYVATRWYRA 190 I ++Y+HS +I HRD+KP NL + LK+ DFG A+ T E Sbjct: 126 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGE------------ 173 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250 Y+++ D+WS+G IM LL G F + I Sbjct: 174 --------KYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-------------------AI 206 Query: 251 SSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 S + P ++ V + L+ +L + +R+T + + H + Q Sbjct: 207 SPGMKTRIRMGQYEFPNPEWSEV----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 262 Query: 311 YHDPDDEPVADPYDQSFESRDLLIDEWK 338 P SR L D+ + Sbjct: 263 -------STKVPQTPLHTSRVLKEDKER 283 >5UIU-A nrPDB Length = 323 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 58/230 (25%), Positives = 101/230 (43%), Gaps = 24/230 (10%) Query: 6 PTFYRQELNKTIWEVPERYQNLS--PVGSGAYGSVCAAFDTKTGLRVAVKKL--SRPFQS 61 +F EL ER ++ +G G +G V + T VAVKKL + Sbjct: 29 HSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITT 86 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVT-HLMGADLNNIVKC- 119 ++ +E++++ +HEN++ LL + +D+ LV ++ L + + C Sbjct: 87 EELKQQFDQEIKVMAKCQHENLVELLGF------SSDGDDLCLVYVYMPNGSLLDRLSCL 140 Query: 120 ---QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD 176 L+ + G+ ++H IHRD+K +N+ ++E KI DFGLAR ++ Sbjct: 141 DGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASE 200 Query: 177 DEMTGY-----VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRT 221 V T Y APE + + DI+S G ++ E++TG Sbjct: 201 KFAQTVMTSRIVGTTAYMAPEALRGEI--TPKSDIYSFGVVLLEIITGLP 248 >5GRN-A nrPDB Length = 356 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 72/330 (21%), Positives = 130/330 (39%), Gaps = 80/330 (24%) Query: 11 QELNKTIWEVPER-YQNLSPVGSGAYGSVCAAF-----DTKTGLRVAVKKLSRPFQSIIH 64 Q + WE P +GSGA+G V ++ ++VAVK L +P Sbjct: 34 QLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKML-KPTARSSE 92 Query: 65 AKRTYRELRLLKHMK-HENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQK- 121 + EL+++ H+ H N++ LL T + +Y++T DL N + + Sbjct: 93 KQALMSELKIMTHLGPHLNIVNLLGACTKSGP------IYIITEYCFYGDLVNYLHKNRD 146 Query: 122 --------------------------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSN 155 LT + YQ+ RG++++ S + +HRDL N Sbjct: 147 SFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARN 206 Query: 156 LAVNEDCELKILDFGLARHTDDEM------TGYVATRWYRAPEIMLNWMHYNQTVDIWSV 209 + + + +KI DFGLAR + + ++ +W APE + + + Y D+WS Sbjct: 207 VLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKW-MAPESIFDNL-YTTLSDVWSY 264 Query: 210 GCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKM 268 G ++ E+ + G T +PG + + N I+S +M K Sbjct: 265 GILLWEIFSLGGTPYPG-----------------------MMVDSTFYNKIKSGYRMAKP 301 Query: 269 NFANVFIGANPLAVDLLEKMLVLDSDKRIT 298 + A +++ K + +KR + Sbjct: 302 D------HATSEVYEIMVKCWNSEPEKRPS 325 >2ZMD-A nrPDB Length = 390 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 68/312 (21%), Positives = 116/312 (37%), Gaps = 54/312 (17%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-HEN 82 Y L +GSG V + K A+K ++ E+ L ++ H + Sbjct: 58 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 83 -VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGLKY 140 +I L D + +Y+V DLN+ +K +K + + +L + Sbjct: 117 KIIRLYDYEITDQ------YIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 170 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT-----GYVATRWYRAPEIML 195 IH I+H DLKP+N + D LK++DFG+A + T V Y PE + Sbjct: 171 IHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIK 229 Query: 196 NWMHYNQ----------TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 + + D+WS+GCI+ + G+T F + I +L Sbjct: 230 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ-----QIINQISKLHAIIDP- 283 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAH 305 N+ +P+ + D+L+ L D +RI+ + LAH Sbjct: 284 -----------NHEIEFPDIPEKDL-----------QDVLKCCLKRDPKQRISIPELLAH 321 Query: 306 AYFAQYHDPDDE 317 Y P ++ Sbjct: 322 PYVQIQTHPVNQ 333 >4HVI-A nrPDB Length = 314 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 68/300 (22%), Positives = 120/300 (40%), Gaps = 40/300 (13%) Query: 14 NKTIWEVPERYQNLSPVGSGAYGSVCAAFDTK----TGLRVAVKKLSRPFQSIIHAKRTY 69 + TI+E + +S +G G +GSV TG VAVK+L + Sbjct: 3 DPTIFE-ERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHS--GPDQQRDFQ 59 Query: 70 RELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQ 128 RE+++LK + + ++ V + LV + L + ++ + D + Sbjct: 60 REIQILKALHSDFIVKYRGVSYGPGR----QSLRLVMEYLPSGCLRDFLQRHRARLDASR 115 Query: 129 FLIY--QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV--- 183 L+Y QI +G++Y+ S +HRDL N+ V + +KI DFGLA+ + YV Sbjct: 116 LLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVRE 175 Query: 184 ----ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239 WY APE + + + +++ D+WS G ++ EL T Sbjct: 176 PGQSPIFWY-APESLSDNI-FSRQSDVWSFGVVLYELFT----------------YCDKS 217 Query: 240 GTPGAELLKKISSE-SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT 298 +P AE L+ + SE + L + + +L++ R + Sbjct: 218 CSPSAEFLRMMGSERDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPS 277 >4M7I-A nrPDB Length = 299 Score = 184 bits (467), Expect = 5e-47, Method: Composition-based stats. Identities = 60/288 (20%), Positives = 124/288 (43%), Gaps = 33/288 (11%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 ++ + +G G +G V A + A+K++ P + + ++ RE++ L ++H Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELA-REKVMREVKALAKLEHPG 64 Query: 83 VIGLLDVFTPARSLEEFND------VYLVTHLM-GADLNNIVKCQKLTDDHVQ----FLI 131 ++ + + + E+ +Y+ L +L + + + ++ + + Sbjct: 65 IVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIF 124 Query: 132 YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------------- 178 QI ++++HS ++HRDLKPSN+ D +K+ DFGL D + Sbjct: 125 LQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAY 184 Query: 179 --MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 TG V T+ Y +PE ++ Y+ VDI+S+G I+ ELL +P + +++++ + Sbjct: 185 ARHTGQVGTKLYMSPE-QIHGNSYSHKVDIFSLGLILFELL-----YPFSTQMERVRTLT 238 Query: 237 RLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDL 284 + L + L+ P + I N + DL Sbjct: 239 DVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDL 286 >3PLS-A nrPDB Length = 298 Score = 183 bits (466), Expect = 8e-47, Method: Composition-based stats. Identities = 55/236 (23%), Positives = 96/236 (40%), Gaps = 21/236 (8%) Query: 28 SPVGSGAYGSVCAAFDT---KTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVI 84 +G G +G V + ++ A+K LSR + + RE L++ + H NV+ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSR-ITEMQQVEAFLREGLLMRGLNHPNVL 85 Query: 85 GLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC--QKLTDDHVQFLIYQILRGLKYIH 142 L+ + P L L+ ++ DL ++ + T + Q+ RG++Y+ Sbjct: 86 ALIGIMLPPEGL----PHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLA 141 Query: 143 SADIIHRDLKPSNLAVNEDCELKILDFGLARHT--------DDEMTGYVATRWYRAPEIM 194 +HRDL N ++E +K+ DFGLAR + +W A E + Sbjct: 142 EQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKW-TALESL 200 Query: 195 LNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 + + D+WS G ++ ELLT G + D D + + P E Sbjct: 201 QTYR-FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPD 255 >3IO7-A nrPDB Length = 313 Score = 183 bits (466), Expect = 8e-47, Method: Composition-based stats. Identities = 68/296 (22%), Positives = 121/296 (40%), Gaps = 38/296 (12%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTK----TGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 + L +G G +GSV TG VAVKKL + H + RE+ +LK Sbjct: 28 RHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE--HLRDFEREIEILKS 85 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQF--LIYQIL 135 ++H+N++ V A N ++ +L L + ++ K DH++ QI Sbjct: 86 LQHDNIVKYKGVCYSAGR---RNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQIC 142 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV-------ATRWY 188 +G++Y+ + IHRDL N+ V + +KI DFGL + + Y WY Sbjct: 143 KGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY 202 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 APE + ++ D+WS G ++ EL T + +P AE ++ Sbjct: 203 -APESL-TESKFSVASDVWSFGVVLYELFT----------------YIEKSKSPPAEFMR 244 Query: 249 KISSESARN-YIQSLTQMPKMNFANVFIGANPLAVDLL-EKMLVLDSDKRITAAQA 302 I ++ + L ++ K N P + ++ + + ++R + Sbjct: 245 MIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 300 >5U6C-A nrPDB Length = 315 Score = 183 bits (465), Expect = 9e-47, Method: Composition-based stats. Identities = 56/264 (21%), Positives = 98/264 (37%), Gaps = 23/264 (8%) Query: 6 PTFYRQELNK--TIWE---VPERYQNLSPV-GSGAYGSVCAAFDTK---TGLRVAVKKLS 56 Y Q + E + L + G G +GSV + T L+VAVK + Sbjct: 14 ENLYFQGSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMK 73 Query: 57 RPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNI 116 S + E +K H NV+ LL V S + ++ + DL+ Sbjct: 74 LDNSSQREIEEFLSEAACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTY 133 Query: 117 VKCQKL-------TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDF 169 + +L + + I G++Y+ + + +HRDL N + +D + + DF Sbjct: 134 LLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADF 193 Query: 170 GLARHTDDEMTGYVATRW-----YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLF 223 GL++ + A E + + + Y D+W+ G M E+ T G T + Sbjct: 194 GLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRV-YTSKSDVWAFGVTMWEIATRGMTPY 252 Query: 224 PGTDHIDQLKLILRLVGTPGAELL 247 PG + + +L E Sbjct: 253 PGVQNHEMYDYLLHGHRLKQPEDC 276 >4HZS-A nrPDB Length = 341 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 62/243 (25%), Positives = 96/243 (39%), Gaps = 23/243 (9%) Query: 22 ERYQNLSPVGSGAYGSVCAA-FDTKTGLRV--AVKKLSRPFQSIIHA-KRTYRELRLLKH 77 + + L +G G++G V +D +G V AVK L S A RE+ + Sbjct: 12 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 71 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHL--MGADLNNIVKCQ-KLTDDHVQFLIYQI 134 + H N+I L V + +VT L +G+ L+ + K Q + Q+ Sbjct: 72 LDHRNLIRLYGVVLTP-------PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQV 124 Query: 135 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV------ATRWY 188 G+ Y+ S IHRDL NL + +KI DFGL R YV + Sbjct: 125 AEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAW 184 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVG-TPGAEL 246 APE + ++ D W G + E+ T G+ + G + L I + P E Sbjct: 185 CAPESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPED 243 Query: 247 LKK 249 + Sbjct: 244 CPQ 246 >4NEU-A nrPDB Length = 333 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 60/330 (18%), Positives = 126/330 (38%), Gaps = 54/330 (16%) Query: 32 SGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFT 91 SG +G V F GL + +K + + I H + E +++ ++H V+ LL V Sbjct: 34 SGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVI- 91 Query: 92 PARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQ-FLIYQILRGLKYIHSADIIHRD 150 +EE ++ ++ +L +++K + T V+ +I +I+ G+ Y+H +IH+D Sbjct: 92 ----IEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKD 147 Query: 151 LKPSNLAVNEDCELKILDFGLA----------------RHTDDEMTGYVATRWYRAPEIM 194 LKP N+ V+ D +KI D GLA R D T +Y APE + Sbjct: 148 LKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHL 207 Query: 195 LN-WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 253 + + D++S ++ + + + QL + ++ P + + + Sbjct: 208 NDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCP- 266 Query: 254 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT---AAQALAHAYFAQ 310 + L++ + + R T + ++ Sbjct: 267 -------------------------REIISLMKLCWEANPEARPTFPGIEEKFR-PFYLS 300 Query: 311 YHDPDDEPVADPYDQSFESRDLLIDEWKSL 340 + E + + + + ++ +SL Sbjct: 301 QLEESVEEDVKSLKKEYSNENAVVKRMQSL 330 >6FEX-A nrPDB Length = 321 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 65/330 (19%), Positives = 120/330 (36%), Gaps = 70/330 (21%) Query: 19 EVPE-RYQNLSPVGSGAYGSVCAA--------------FDTKTGL--RVAVKKLSRPFQS 61 + P R + +G G +G V + + G VAVK L RP + Sbjct: 12 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL-RPDAT 70 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 +E++++ +K N+I LL V L + ++ DLN + + Sbjct: 71 KNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPL-----CMITDYMENGDLNQFLSAHQ 125 Query: 122 LTDDHV--------------QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKIL 167 L D + QI G++Y+ + + +HRDL N V E+ +KI Sbjct: 126 LEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIA 185 Query: 168 DFGLARHTDDEMTGYVATRW-----YRAPEIMLNWMHYNQTVDIWSVGCIMAE--LLTGR 220 DFG++R+ V R + A E +L + D+W+ G + E +L Sbjct: 186 DFGMSRNLYAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCRA 244 Query: 221 TLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPL 280 F G E + + + E R+ + + + + Sbjct: 245 QPF----------------GQLTDEQVIENAGEFFRDQGRQV-------YLSRPPACPQG 281 Query: 281 AVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 +L+ + +S++R +Q H + A+ Sbjct: 282 LYELMLRCWSRESEQRPPFSQL--HRFLAE 309 >3BBT-B nrPDB Length = 328 Score = 181 bits (459), Expect = 5e-46, Method: Composition-based stats. Identities = 70/309 (22%), Positives = 122/309 (39%), Gaps = 26/309 (8%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRV----AVKKLSRPFQSIIHAKRTYRELRLLKHM 78 + + +GSGA+G+V G V A+K L+ + + E ++ M Sbjct: 16 ELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVE-FMDEALIMASM 74 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK--LTDDHVQFLIYQIL 135 H +++ LL V + LVT LM L V K + + QI Sbjct: 75 DHPHLVRLLGVCLSP-------TIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIA 127 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW-----YRA 190 +G+ Y+ ++HRDL N+ V +KI DFGLAR + + Y A + A Sbjct: 128 KGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMA 187 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLK- 248 E + ++ + D+WS G + EL+T G + G + L+ + P + Sbjct: 188 LECI-HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTI 246 Query: 249 KISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 + + ++ PK F + + +A D ++ LV+ D R+ +F Sbjct: 247 DVYMVMVKCWMIDADSRPK--FKELAAEFSRMARD-PQRYLVIQGDDRMKLPSPNDSKFF 303 Query: 309 AQYHDPDDE 317 D +D Sbjct: 304 QNLLDEEDL 312 >1U54-B nrPDB Length = 291 Score = 180 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 62/243 (25%), Positives = 96/243 (39%), Gaps = 23/243 (9%) Query: 22 ERYQNLSPVGSGAYGSVCAA-FDTKTGLRV--AVKKLSRPFQSIIHA-KRTYRELRLLKH 77 + + L +G G++G V +D +G V AVK L S A RE+ + Sbjct: 18 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 77 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHL--MGADLNNIVKCQ-KLTDDHVQFLIYQI 134 + H N+I L V + +VT L +G+ L+ + K Q + Q+ Sbjct: 78 LDHRNLIRLYGVVLTP-------PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQV 130 Query: 135 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV------ATRWY 188 G+ Y+ S IHRDL NL + +KI DFGL R YV + Sbjct: 131 AEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAW 190 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVG-TPGAEL 246 APE + ++ D W G + E+ T G+ + G + L I + P E Sbjct: 191 CAPESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPED 249 Query: 247 LKK 249 + Sbjct: 250 CPQ 252 >1U59-A nrPDB Length = 287 Score = 180 bits (457), Expect = 9e-46, Method: Composition-based stats. Identities = 53/233 (22%), Positives = 102/233 (43%), Gaps = 23/233 (9%) Query: 29 PVGSGAYGSVCAA--FDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGL 86 +G G +GSV K + VA+K L + + + RE +++ + + ++ L Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA-DTEEMMREAQIMHQLDNPYIVRL 75 Query: 87 LDVFTPARSLEEFNDVYLVTHLMGAD-LNNIV--KCQKLTDDHVQFLIYQILRGLKYIHS 143 + V + + LV + G L+ + K +++ +V L++Q+ G+KY+ Sbjct: 76 IGVC-------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 128 Query: 144 ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVAT-------RWYRAPEIMLN 196 + +HRDL N+ + KI DFGL++ + + Y A +WY APE + N Sbjct: 129 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECI-N 186 Query: 197 WMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 + ++ D+WS G M E L+ G+ + + + I + Sbjct: 187 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP 239 >6CTH-A nrPDB Length = 309 Score = 180 bits (457), Expect = 9e-46, Method: Composition-based stats. Identities = 57/211 (27%), Positives = 103/211 (48%), Gaps = 19/211 (9%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 V + + +G G +GSV F + +AVKK+SR + I K E++++ ++ Sbjct: 13 VTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGI--KEYASEVKIISRLR 70 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLN-NIVKCQKLTDDHVQF-LIYQILR 136 H+N++ L+ E ++ LV M L+ +I K + L V++ ++ + Sbjct: 71 HKNLVKLIGWC------HERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLAS 124 Query: 137 GLKYIHSAD---IIHRDLKPSNLAVNEDCELKILDFGLARHTDD----EMTGYVATRWYR 189 L Y+H ++HRD+K SN+ ++ K+ DFGLAR D + T T Y Sbjct: 125 ALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYM 184 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGR 220 APE + + ++ D++S G + E+ +GR Sbjct: 185 APECLSSGKA-SKESDVYSFGVVALEIASGR 214 >6BSD-A nrPDB Length = 876 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 65/336 (19%), Positives = 120/336 (35%), Gaps = 76/336 (22%) Query: 19 EVPE-RYQNLSPVGSGAYGSVCAA--------------FDTKTGL--RVAVKKLSRPFQS 61 + P R + +G G +G V + + G VAVK L RP + Sbjct: 567 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL-RPDAT 625 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 +E++++ +K N+I LL V L + ++ DLN + + Sbjct: 626 KNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPL-----CMITDYMENGDLNQFLSAHQ 680 Query: 122 LTDDHV--------------------QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNED 161 L D + QI G++Y+ + + +HRDL N V E+ Sbjct: 681 LEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGEN 740 Query: 162 CELKILDFGLARHTDDEMTGYVATRW-----YRAPEIMLNWMHYNQTVDIWSVGCIMAE- 215 +KI DFG++R+ V R + A E +L + D+W+ G + E Sbjct: 741 FTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEV 799 Query: 216 -LLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVF 274 +L F G E + + + E R+ + + + + Sbjct: 800 LMLCRAQPF----------------GQLTDEQVIENAGEFFRDQGRQV-------YLSRP 836 Query: 275 IGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 +L+ + +S++R +Q H + A+ Sbjct: 837 PACPQGLYELMLRCWSRESEQRPPFSQL--HRFLAE 870 >2A1A-B nrPDB Length = 284 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 63/298 (21%), Positives = 120/298 (40%), Gaps = 58/298 (19%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 ++ + +GSG +G V A G +K++ + ++ RE++ L + H N Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVK------YNNEKAEREVKALAKLDHVN 65 Query: 83 VIGLLDVF----------TPARSLEEFNDVYLVTHLMG-ADLNNIV---KCQKLTDDHVQ 128 ++ + + S + +++ L + + +KL Sbjct: 66 IVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLAL 125 Query: 129 FLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGL--ARHTDDEMTGYVATR 186 L QI +G+ YIHS +I+RDLKPSN+ + + ++KI DFGL + D + T T Sbjct: 126 ELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTL 185 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 Y +PE ++ Y + VD++++G I+AELL Sbjct: 186 RYMSPE-QISSQDYGKEVDLYALGLILAELL----------------------------- 215 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304 ++A + T + +++F LL+K+L + R ++ L Sbjct: 216 ---HVCDTAFETSKFFTDLRDGIISDIFDKKEKT---LLQKLLSKKPEDRPNTSEILR 267 >4TPT-A nrPDB Length = 303 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 52/215 (24%), Positives = 88/215 (40%), Gaps = 32/215 (14%) Query: 27 LSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGL 86 +G G +G TG + +K+L R + K E+++++ + H NV+ Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEET--QKTFLTEVKVMRSLDHPNVLKF 62 Query: 87 LDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQILRGLKYIHSAD 145 + V + L L ++ G L + ++ I G+ Y+HS Sbjct: 63 IGVLYKDKKLN-----LLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMC 117 Query: 146 IIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT-----------------------GY 182 IIHRDL N + D + + DFGL+R +E Sbjct: 118 IIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTV 177 Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 V ++ APE MLN Y++TVDI+S G ++ E++ Sbjct: 178 VGNPYWMAPE-MLNGKSYDETVDIFSFGIVLCEII 211 >3PP0-A nrPDB Length = 338 Score = 178 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 64/239 (26%), Positives = 100/239 (41%), Gaps = 24/239 (10%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRV----AVKKLSRPFQSIIHAKRTYRELRLLKHM 78 + + +GSGA+G+V G V A+K L R S K E ++ + Sbjct: 18 ELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVL-RENTSPKANKEILDEAYVMAGV 76 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVK-CQKLTDDHVQFLIYQIL 135 V LL + + V LVT LM G L+++ + +L + QI Sbjct: 77 GSPYVSRLLGICLTS-------TVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIA 129 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY------VATRWYR 189 +G+ Y+ ++HRDL N+ V +KI DFGLAR D + T Y V +W Sbjct: 130 KGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKW-M 188 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELL 247 A E +L + D+WS G + EL+T G + G + L+ + P + Sbjct: 189 ALESILRRR-FTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPIC 246 >3I81-A nrPDB Length = 315 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 53/312 (16%), Positives = 108/312 (34%), Gaps = 62/312 (19%) Query: 15 KTIWEVP-ERYQNLSPVGSGAYGSVCAAFDT-----KTGLRVAVKKLSRPFQSIIHAKRT 68 WEV E+ +G G++G V + RVA+K ++ S+ Sbjct: 10 PDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAA-SMRERIEF 68 Query: 69 YRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDD-- 125 E ++K +V+ LL V + + ++ LM DL + ++ + + Sbjct: 69 LNEASVMKEFNCHHVVRLLGVVSQGQPT------LVIMELMTRGDLKSYLRSLRPEMENN 122 Query: 126 ---------HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD 176 + + +I G+ Y+++ +HRDL N V ED +KI DFG+ R Sbjct: 123 PVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY 182 Query: 177 DEMTGYVATRW-----YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHID 230 + + + +PE + + + + D+WS G ++ E+ T + G + Sbjct: 183 ETDYYRKGGKGLLPVRWMSPESLKDGV-FTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQ 241 Query: 231 QLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLV 290 L+ ++ + + E L+ Sbjct: 242 VLRFVMEGGLLDKPDNCPDMLFE------------------------------LMRMCWQ 271 Query: 291 LDSDKRITAAQA 302 + R + + Sbjct: 272 YNPKMRPSFLEI 283 >2OZO-A nrPDB Length = 613 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 52/233 (22%), Positives = 102/233 (43%), Gaps = 23/233 (9%) Query: 29 PVGSGAYGSVCAA--FDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGL 86 +G G +GSV K + VA+K L + + + RE +++ + + ++ L Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA-DTEEMMREAQIMHQLDNPYIVRL 401 Query: 87 LDVFTPARSLEEFNDVYLVTHLMGAD-LNNIV--KCQKLTDDHVQFLIYQILRGLKYIHS 143 + V + + LV + G L+ + K +++ +V L++Q+ G+KY+ Sbjct: 402 IGVC-------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 Query: 144 ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVAT-------RWYRAPEIMLN 196 + +HR+L N+ + KI DFGL++ + + Y A +WY APE + N Sbjct: 455 KNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECI-N 512 Query: 197 WMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 + ++ D+WS G M E L+ G+ + + + I + Sbjct: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP 565 >5GNK-A nrPDB Length = 297 Score = 177 bits (449), Expect = 8e-45, Method: Composition-based stats. Identities = 60/239 (25%), Positives = 103/239 (43%), Gaps = 24/239 (10%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRV----AVKKLSRPFQSIIHAKRTYRELRLLKHM 78 ++ + +GSGA+G+V G +V A+K+L R S K E ++ + Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASV 78 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK--LTDDHVQFLIYQIL 135 + +V LL + + V L+ LM L + V+ K + ++ QI Sbjct: 79 DNPHVCRLLGICLTS-------TVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIA 131 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY------VATRWYR 189 +G+ Y+ ++HRDL N+ V +KI DFGLA+ E Y V +W Sbjct: 132 KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW-M 190 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELL 247 A E +L+ + Y D+WS G + EL+T G + G + ++ + P + Sbjct: 191 ALESILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPIC 248 >3LZB-A nrPDB Length = 327 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 66/275 (24%), Positives = 114/275 (41%), Gaps = 25/275 (9%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRV----AVKKLSRPFQSIIHAKRTYRELRLLKHM 78 ++ + +GSGA+G+V G +V A+K+L R S K E ++ + Sbjct: 16 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASV 74 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK--LTDDHVQFLIYQIL 135 + +V LL + + V L+T LM L + V+ K + ++ QI Sbjct: 75 DNPHVCRLLGICLTS-------TVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIA 127 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY------VATRWYR 189 +G+ Y+ ++HRDL N+ V +KI DFGLA+ E Y V +W Sbjct: 128 KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW-M 186 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 A E +L+ + Y D+WS G + EL+T G + G + ++ + P + Sbjct: 187 ALESILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPIC- 244 Query: 249 KISSESARNYIQSLTQMPKMNFANVFIGANPLAVD 283 I + + F + I + +A D Sbjct: 245 TIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARD 279 >3Q4U-A nrPDB Length = 301 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 72/313 (23%), Positives = 116/313 (37%), Gaps = 61/313 (19%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK--H 77 V L VG G YG V + G VAVK S K +RE L Sbjct: 6 VARDITLLECVGKGRYGEVWRG--SWQGENVAVKIF-----SSRDEKSWFRETELYNTVM 58 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQKLTDDHVQFLIYQILR 136 ++HEN++G + + S ++L+TH L + ++ L ++ I Sbjct: 59 LRHENILGFIA--SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIAS 116 Query: 137 GLKYIH--------SADIIHRDLKPSNLAVNEDCELKILDFGLA-------RHTDDEMTG 181 GL ++H I HRDLK N+ V ++ + I D GLA D Sbjct: 117 GLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNP 176 Query: 182 YVATRWYRAPEIMLNWMHYN-----QTVDIWSVGCIMAELLTG----------RTLFPGT 226 V T+ Y APE++ + + + VDIW+ G ++ E+ + F Sbjct: 177 RVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDV 236 Query: 227 DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLE 286 D P E ++K+ Q +P F++ LA L++ Sbjct: 237 VPND-----------PSFEDMRKVVCVD-----QQRPNIPNRWFSD--PTLTSLAK-LMK 277 Query: 287 KMLVLDSDKRITA 299 + + R+TA Sbjct: 278 ECWYQNPSARLTA 290 >3UIU-A nrPDB Length = 306 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 66/311 (21%), Positives = 122/311 (39%), Gaps = 71/311 (22%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 ++ + +GSG +G V A G ++++ + ++ RE++ L + H N Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVK------YNNEKAEREVKALAKLDHVN 66 Query: 83 VIGLLDVF--------TPARSLEEFND---------------VYLVTHLMG-ADLNNIV- 117 ++ + T SLE + +++ L + Sbjct: 67 IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIE 126 Query: 118 --KCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGL--AR 173 + +KL L QI +G+ YIHS +IHRDLKPSN+ + + ++KI DFGL + Sbjct: 127 KRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 186 Query: 174 HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLK 233 D + T T Y +PE ++ Y + VD++++G I+AELL Sbjct: 187 KNDGKRTRSKGTLRYMSPE-QISSQDYGKEVDLYALGLILAELL---------------- 229 Query: 234 LILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDS 293 ++A + T + +++F LL+K+L Sbjct: 230 ----------------HVCDTAFETSKFFTDLRDGIISDIFDKKEKT---LLQKLLSKKP 270 Query: 294 DKRITAAQALA 304 + R ++ L Sbjct: 271 EDRPNTSEILR 281 >2RIO-A nrPDB Length = 434 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 85/358 (23%), Positives = 145/358 (40%), Gaps = 82/358 (22%) Query: 28 SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-HENVIGL 86 +G G+ G+V + G VAVK++ F I E++LL H NVI Sbjct: 21 KILGYGSSGTVVF-QGSFQGRPVAVKRMLIDFCDI-----ALMEIKLLTESDDHPNVIRY 74 Query: 87 LDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQF--------LIYQILRGL 138 T R L Y+ L +L ++V+ + ++D++++ L+ QI G+ Sbjct: 75 YCSETTDRFL------YIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGV 128 Query: 139 KYIHSADIIHRDLKPSNLAVN-------------EDCELKILDFGLARHTDDEMTGYV-- 183 ++HS IIHRDLKP N+ V+ E+ + I DFGL + D + + Sbjct: 129 AHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTN 188 Query: 184 -----ATRWYRAPEI------MLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQ 231 T +RAPE+ + +++DI+S+GC+ +L+ G+ F D + Sbjct: 189 LNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF--GDKYSR 246 Query: 232 LKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVL 291 I+R + + L ++ R+ I A DL+ +M+ Sbjct: 247 ESNIIRGIFS-----LDEMKCLHDRSLIA-------------------EATDLISQMIDH 282 Query: 292 DSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFV 349 D KR TA + L H F P + + + D L E + ++ F Sbjct: 283 DPLKRPTAMKVLRHPLF--------WPKSKKLEFLLKVSDRLEIENRDPPSALLMKFD 332 >4IDT-A nrPDB Length = 356 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 69/313 (22%), Positives = 115/313 (36%), Gaps = 64/313 (20%) Query: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 +G G++G V D +TG + AVKK+ EL + ++ L Sbjct: 81 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE-------ELMACAGLTSPRIVPLYG 133 Query: 89 VFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGLKYIHSADII 147 + F ++ L G L +VK Q L +D + + Q L GL+Y+HS I+ Sbjct: 134 AVREGPWVNIFMEL-----LEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRIL 188 Query: 148 HRDLKPSNLAVNEDC-ELKILDFGLARHTDDE-------MTGYV-ATRWYRAPEIMLNWM 198 H D+K N+ ++ D + DFG A + Y+ T + APE++L Sbjct: 189 HGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGR- 247 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNY 258 + VD+WS C+M +L G + L KI+SE Sbjct: 248 SCDAKVDVWSSCCMMLHMLNGCHPW---------------TQFFRGPLCLKIASE----- 287 Query: 259 IQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQA-------------LAH 305 + PL +++ L + R++AA+ L Sbjct: 288 --------PPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKS 339 Query: 306 AYFAQYHDPDDEP 318 + +Y +P P Sbjct: 340 PWRGEYKEPRHPP 352 >5TOS-A nrPDB Length = 395 Score = 174 bits (441), Expect = 5e-44, Method: Composition-based stats. Identities = 64/304 (21%), Positives = 118/304 (38%), Gaps = 42/304 (13%) Query: 22 ERYQNLSPVGSGAYGSVCAAF---------DTKTGLRVAVKKLSRPFQSIIHAKRTYREL 72 ++ S +G G +G V + TGL +AVKKL+ + + E+ Sbjct: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN--QEGFQGHREWLTEI 122 Query: 73 RLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-----LTDDHV 127 L + H N++ L+ LE+ + + + + L N + + L Sbjct: 123 NYLGQLSHPNLVKLIGYC-----LEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 Query: 128 QFLIYQILRGLKYIHS--ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV-- 183 + +GL ++HS +I+RD+K SN+ ++ D K+ DFGLAR YV Sbjct: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 Query: 184 ---ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240 T Y APE M + H N D++S G ++ E+L+G+ + L+ Sbjct: 238 RVMGTYGYAAPEYM-SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV----- 291 Query: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300 + + + + + ++ + +AV + L + R T Sbjct: 292 ----DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAV----QCLSFEPKSRPTMD 343 Query: 301 QALA 304 Q + Sbjct: 344 QVVR 347 >2BUJ-A nrPDB Length = 317 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 65/327 (19%), Positives = 120/327 (36%), Gaps = 56/327 (17%) Query: 4 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII 63 R Y Q I + Y + +G G + V G A+K++ Sbjct: 13 GRENLYFQGHMVIIDN--KHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRIL--CHEQQ 68 Query: 64 HAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV----KC 119 + RE + + H N++ L+ R + + L G N I K Sbjct: 69 DREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKG 128 Query: 120 QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH----- 174 LT+D + +L+ I RGL+ IH+ HRDLKP+N+ + ++ + ++D G Sbjct: 129 NFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHV 188 Query: 175 -------TDDEMTGYVATRWYRAPEIMLNWMH--YNQTVDIWSVGCIMAELLTGRTLFPG 225 T + T YRAPE+ H ++ D+WS+GC++ ++ G + Sbjct: 189 EGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY-- 246 Query: 226 TDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLL 285 ++ + + + ++S + + +L Q LL Sbjct: 247 -------DMVFQKGDSVALAVQNQLSIPQSPRHSSALWQ-------------------LL 280 Query: 286 EKMLVLDSDKRI------TAAQALAHA 306 M+ +D +R + +AL Sbjct: 281 NSMMTVDPHQRPHIPLLLSQLEALQPP 307 >4PL5-B nrPDB Length = 435 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 76/298 (25%), Positives = 117/298 (39%), Gaps = 59/298 (19%) Query: 29 PVGSGAYGS-VCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-HENVIGL 86 +G GA G+ V VAVK++ S RE++LL+ H NVI Sbjct: 34 VLGHGAEGTIVYKG--MFDNRDVAVKRILPECFSFAD-----REVQLLRESDEHPNVIRY 86 Query: 87 LDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDD--HVQFLIYQILRGLKYIHSA 144 T + Y+ L A L V+ + L++Q GL ++HS Sbjct: 87 F--CTEK----DRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSL 140 Query: 145 DIIHRDLKPSNLAV---NEDCELK--ILDFGLA------RHTDDEMTGYVATRWYRAPEI 193 +I+HRDLKP N+ + N +K I DFGL RH+ +G T + APE+ Sbjct: 141 NIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 200 Query: 194 MLNWMHY--NQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250 + TVDI+S GC+ +++ G F G Q ++L K Sbjct: 201 LSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQANILLGACNLDCFHSDK-- 257 Query: 251 SSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 + +A +L+EKM+ +D +R +A L H +F Sbjct: 258 -------------------------HEDVIARELIEKMIAMDPQQRPSAKHVLKHPFF 290 >4LRM-A nrPDB Length = 334 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 61/242 (25%), Positives = 104/242 (42%), Gaps = 27/242 (11%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRV----AVKKLSRPFQSIIHAKRTYRELRLLKHM 78 ++ + +GSGA+G+V G +V A+K+L R S K E ++ + Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASV 78 Query: 79 KHE---NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK--LTDDHVQFLIY 132 + +V LL + + V L+T LM L + V+ K + ++ Sbjct: 79 DNPGNPHVCRLLGICLTS-------TVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCV 131 Query: 133 QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY------VATR 186 QI +G+ Y+ ++HRDL N+ V +KI DFGLA+ E Y V + Sbjct: 132 QIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIK 191 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAE 245 W A E +L+ + Y D+WS G + EL+T G + G + ++ + P Sbjct: 192 W-MALESILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPP 249 Query: 246 LL 247 + Sbjct: 250 IC 251 >6HV0-A nrPDB Length = 416 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 79/298 (26%), Positives = 119/298 (39%), Gaps = 59/298 (19%) Query: 29 PVGSGAYGS-VCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-HENVIGL 86 +G GA G+ V VAVK++ S RE++LL+ H NVI Sbjct: 15 VLGHGAEGTIVYRG--MFDNRDVAVKRILPECFSFAD-----REVQLLRESDEHPNVIRY 67 Query: 87 LDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDD--HVQFLIYQILRGLKYIHSA 144 T + Y+ L A L V+ + L+ Q GL ++HS Sbjct: 68 F--CTEK----DRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSL 121 Query: 145 DIIHRDLKPSNLAV---NEDCELK--ILDFGLA------RHTDDEMTGYVATRWYRAPEI 193 +I+HRDLKP N+ + N ++K I DFGL RH+ +G T + APE+ Sbjct: 122 NIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 181 Query: 194 MLNWMHY--NQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250 + TVDI+S GC+ +++ G F G Q ++L L + Sbjct: 182 LSEDCKENPTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQANILLGACS------LDCL 234 Query: 251 SSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 E + I A +L+EKM+ +D KR +A L H +F Sbjct: 235 HPEKHEDVI---------------------ARELIEKMIAMDPQKRPSAKHVLKHPFF 271 >5LPZ-A nrPDB Length = 332 Score = 170 bits (432), Expect = 6e-43, Method: Composition-based stats. Identities = 66/248 (26%), Positives = 108/248 (43%), Gaps = 33/248 (13%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 + N S +GSG +G V A K G VA+KKL S + E+ + +KH N+ Sbjct: 19 FHNDSLIGSGGFGDVYKAI-LKDGSAVAIKKLIHV--SGQGDREFMAEMETIGKIKHRNL 75 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQK-----LTDDHVQFLIYQILRG 137 + LL ++ LV M L +++ K L + + RG Sbjct: 76 VPLLGYCKVG------DERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARG 129 Query: 138 LKYIHSA---DIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-----EMTGYVATRWYR 189 L ++H IIHRD+K SN+ ++E+ E ++ DFG+AR ++ T Y Sbjct: 130 LAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYV 189 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTL-----FPGTD---HIDQLKLILRLVGT 241 PE ++ + D++S G ++ ELLTG+ F + + Q LR+ Sbjct: 190 PPEYYQSFR-CSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAK-LRISDV 247 Query: 242 PGAELLKK 249 EL+K+ Sbjct: 248 FDPELMKE 255 >5LPV-A nrPDB Length = 296 Score = 170 bits (431), Expect = 8e-43, Method: Composition-based stats. Identities = 66/248 (26%), Positives = 108/248 (43%), Gaps = 33/248 (13%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 + N S +GSG +G V A K G VA+KKL S + E+ + +KH N+ Sbjct: 19 FHNDSLIGSGGFGDVYKAI-LKDGSAVAIKKLIHV--SGQGDREFMAEMETIGKIKHRNL 75 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQK-----LTDDHVQFLIYQILRG 137 + LL ++ LV M L +++ K L + + RG Sbjct: 76 VPLLGYCKVG------DERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARG 129 Query: 138 LKYIHSA---DIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-----EMTGYVATRWYR 189 L ++H IIHRD+K SN+ ++E+ E ++ DFG+AR ++ T Y Sbjct: 130 LAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYV 189 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTL-----FPGTD---HIDQLKLILRLVGT 241 PE ++ + D++S G ++ ELLTG+ F + + Q LR+ Sbjct: 190 PPEYYQSFR-CSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAK-LRISDV 247 Query: 242 PGAELLKK 249 EL+K+ Sbjct: 248 FDPELMKE 255 >6J5U-C nrPDB Length = 426 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 60/301 (19%), Positives = 113/301 (37%), Gaps = 40/301 (13%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKT---------GLRVAVKKLSRPFQSIIHAKRTYREL 72 + ++ + +G G +G V + +T G+ VAVK+L + K E+ Sbjct: 84 KNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLK--PEGFQGHKEWLTEV 141 Query: 73 RLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV---KCQKLTDDHVQF 129 L + H N++ L+ N + + + L N + Q LT Sbjct: 142 NYLGQLSHPNLVLLVGYCAEGE-----NRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMK 196 Query: 130 LIYQILRGLKYIHSAD--IIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEMTGY 182 + +GL ++H A +I+RD K +N+ ++ D K+ DFGLA+ T Sbjct: 197 VAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKV 256 Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 242 + T Y APE + D++S G ++ EL++GR ++ ++ L+ Sbjct: 257 IGTHGYAAPEYVATGRL-TAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLV------- 308 Query: 243 GAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQA 302 R + + + A +L + L D+ R ++ Sbjct: 309 ---DWATPYLGDKRKLFRIMDTKLGGQYPQKGAFT---AANLALQCLNPDAKLRPKMSEV 362 Query: 303 L 303 L Sbjct: 363 L 363 >1PY5-A nrPDB Length = 326 Score = 169 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 57/257 (22%), Positives = 101/257 (39%), Gaps = 33/257 (12%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK--H 77 + +G G +G V G VAVK S + +RE + + Sbjct: 27 IARTIVLQESIGKGRFGEVWRGKWR--GEEVAVKIF-----SSREERSWFREAEIYQTVM 79 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHL-MGADLNNIVKCQKLTDDHVQFLIYQILR 136 ++HEN++G + + + ++LV+ L + + +T + + L Sbjct: 80 LRHENILGFIAA--DNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTAS 137 Query: 137 GLKYIH--------SADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG------- 181 GL ++H I HRDLK N+ V ++ I D GLA D Sbjct: 138 GLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNH 197 Query: 182 YVATRWYRAPEIM---LNWMHYN--QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 V T+ Y APE++ +N H+ + DI+++G + E+ ++ G QL Sbjct: 198 RVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYD 256 Query: 237 RLVGTPGAELLKKISSE 253 + P E ++K+ E Sbjct: 257 LVPSDPSVEEMRKVVCE 273 >6FER-A nrPDB Length = 309 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 60/318 (18%), Positives = 108/318 (33%), Gaps = 63/318 (19%) Query: 19 EVPERYQNLS-PVGSGAYGSVCAA--------------FDTKTGL--RVAVKKLSRPFQS 61 E P + +G G +G V D VAVK L Sbjct: 5 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK 64 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-- 119 +E++++ +K N+I LL V L + ++ DLN + Sbjct: 65 NARN-DFLKEIKIMSRLKDPNIIHLLAVCITDDPL-----CMITEYMENGDLNQFLSRHE 118 Query: 120 ---------QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFG 170 + ++ +++F+ QI G+KY+ S + +HRDL N V ++ +KI DFG Sbjct: 119 PPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFG 178 Query: 171 LARHTDD------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFP 224 ++R+ + + RW I+L + D+W+ G + E T F Sbjct: 179 MSRNLYSGDYYRIQGRAVLPIRWMSWESILLG--KFTTASDVWAFGVTLWETFT----FC 232 Query: 225 GTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDL 284 QL E + + + E R+ + + L Sbjct: 233 QEQPYSQL----------SDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYK-------L 275 Query: 285 LEKMLVLDSDKRITAAQA 302 + D+ R + + Sbjct: 276 MLSCWRRDTKNRPSFQEI 293 >2PMN-X nrPDB Length = 348 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 69/323 (21%), Positives = 123/323 (38%), Gaps = 51/323 (15%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHA---------------KR 67 Y+ + + G + + K A+KK + Sbjct: 32 DYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYDD 89 Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL----- 122 EL+++ +K+E T + +++VY++ M D +I+K + Sbjct: 90 FKNELQIITDIKNE------YCLTCEGIITNYDEVYIIYEYMEND--SILKFDEYFFVLD 141 Query: 123 -------TDDHVQFLIYQILRGLKYIH-SADIIHRDLKPSNLAVNEDCELKILDFGLARH 174 ++ +I +L YIH +I HRD+KPSN+ ++++ +K+ DFG + + Sbjct: 142 KNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEY 201 Query: 175 T-DDEMTGYVATRWYRAPEIMLNWMHY-NQTVDIWSVGCIMAELLTGRTLFPGTDHIDQL 232 D ++ G T + PE N Y VDIWS+G + + F Sbjct: 202 MVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPF--------- 252 Query: 233 KLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLD 292 L + LV K I RN+ K +N F+ + +D L+ L + Sbjct: 253 SLKISLVELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFL--SNEDIDFLKLFLRKN 310 Query: 293 SDKRITAAQALAHAYFAQYHDPD 315 +RIT+ AL H + A + D Sbjct: 311 PAERITSEDALKHEWLADTNIED 333 >5WNL-A nrPDB Length = 342 Score = 168 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 66/342 (19%), Positives = 124/342 (36%), Gaps = 49/342 (14%) Query: 28 SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLL 87 VGSG +G V +A+K E + ++ K ++ + Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVY 85 Query: 88 DVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQKLTDDHVQFLIYQILRGLKYIH--SA 144 + V LV M L ++ + L D ++++ G+ ++H S Sbjct: 86 GICQEP--------VGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSP 137 Query: 145 DIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDD-EMTGYVATRWYRAPEIMLNWM 198 ++H +LKP+N+ ++ +KI DFGLA+ H+ D M G T Y PE + Sbjct: 138 PLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKS 197 Query: 199 H-YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257 ++ D++S ++ +LT + F D + L +++++V EL Sbjct: 198 RLFDTKHDVYSFAIVIWGVLTQKKPF--ADEKNILHIMMKVVKGHRPELPPICRPR---- 251 Query: 258 YIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDE 317 A + L+++ D R T + ++ D ++ Sbjct: 252 -----------------PRACASLIGLMQRCWHADPQVRPTFQEIT-----SETEDLCEK 289 Query: 318 PVADPYDQSFESRDLLIDEWKSLTYDEVISFV---PPPLDQE 356 P + D + E + E KS E PP D + Sbjct: 290 PDEEVKDLAHEPGEKSSLESKSEARPESSRLKRASAPPFDND 331 >3MDY-A nrPDB Length = 337 Score = 168 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 67/303 (22%), Positives = 116/303 (38%), Gaps = 41/303 (13%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH-- 77 + ++ Q + +G G YG V G +VAVK ++ +RE + + Sbjct: 35 IAKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEAS-----WFRETEIYQTVL 87 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHL-MGADLNNIVKCQKLTDDHVQFLIYQILR 136 M+HEN++G + + + +YL+T L + +K L + L Y + Sbjct: 88 MRHENILGFIAA--DIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVS 145 Query: 137 GLKYIH--------SADIIHRDLKPSNLAVNEDCELKILDFGLA-------RHTDDEMTG 181 GL ++H I HRDLK N+ V ++ I D GLA D Sbjct: 146 GLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNT 205 Query: 182 YVATRWYRAPEIM---LNWMHYNQTV--DIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 236 V T+ Y PE++ LN H+ + D++S G I+ E+ G QL Sbjct: 206 RVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS-GGIVEEYQLPYHD 264 Query: 237 RLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKR 296 + P E +++I + P ++ + L+ + + R Sbjct: 265 LVPSDPSYEDMREIVC-----IKKLRPSFPNRWSSDECLRQMGK---LMTECWAHNPASR 316 Query: 297 ITA 299 +TA Sbjct: 317 LTA 319 >4JLC-A nrPDB Length = 657 Score = 167 bits (424), Expect = 6e-42, Method: Composition-based stats. Identities = 56/244 (22%), Positives = 99/244 (40%), Gaps = 29/244 (11%) Query: 11 QELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTY 69 Q + +W + + +G GA +V KTG AVK + F + + Sbjct: 3 QSTSNHLWLLSD------ILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--M 54 Query: 70 RELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ----KLTDD 125 RE +LK + H+N++ L F + V ++ L +++ L + Sbjct: 55 REFEVLKKLNHKNIVKL---FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPES 111 Query: 126 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLA--VNEDCE--LKILDFGLARHTDDE--M 179 ++ ++ G+ ++ I+HRD+KP N+ + ED + K+ DFG AR +D+ Sbjct: 112 EFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF 171 Query: 180 TGYVATRWYRAPEIMLN-------WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQL 232 T Y P++ Y TVD+WSVG TG F + + Sbjct: 172 VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRN 231 Query: 233 KLIL 236 K ++ Sbjct: 232 KEVM 235 >4EUU-A nrPDB Length = 319 Score = 167 bits (422), Expect = 8e-42, Method: Composition-based stats. Identities = 53/247 (21%), Positives = 99/247 (40%), Gaps = 29/247 (11%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAK 66 Q + +W + + +G GA +V KTG A+K + F + + Sbjct: 1 MGSQSTSNHLWLLSD------ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ 54 Query: 67 RTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ----KL 122 RE +LK + H+N++ L F + V ++ L +++ L Sbjct: 55 --MREFEVLKKLNHKNIVKL---FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGL 109 Query: 123 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLA--VNEDCE--LKILDFGLARHTDDE 178 + ++ ++ G+ ++ I+HR++KP N+ + ED + K+ DFG AR +D+ Sbjct: 110 PESEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD 169 Query: 179 --MTGYVATRWYRAPEIMLN-------WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI 229 T Y P++ Y TVD+WS+G TG F + Sbjct: 170 EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP 229 Query: 230 DQLKLIL 236 + K ++ Sbjct: 230 RRNKEVM 236 >4F0G-A nrPDB Length = 287 Score = 167 bits (422), Expect = 9e-42, Method: Composition-based stats. Identities = 55/286 (19%), Positives = 106/286 (37%), Gaps = 51/286 (17%) Query: 28 SPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-----PFQSIIHAKRTYRELRLLKHMKHEN 82 +G G +G V K VA+K L + I + RE+ ++ ++ H N Sbjct: 25 KQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPN 84 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIV--KCQKLTDDHVQFLIYQILRGLK 139 ++ L + +V + DL + + K + L+ I G++ Sbjct: 85 IVKLYGLMHNPPR--------MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGIE 136 Query: 140 YIHSAD--IIHRDLKPSNLA---VNEDCEL--KILDFGLARHTDDEMTGYVATRWYRAPE 192 Y+ + + I+HRDL+ N+ ++E+ + K+ DFGL++ + ++G + + APE Sbjct: 137 YMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVSGLLGNFQWMAPE 196 Query: 193 IM-LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 + Y + D +S I+ +LTG F + + + I Sbjct: 197 TIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKI-------------KFINMIR 243 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI 297 E R + P +++E D KR Sbjct: 244 EEGLR--------------PTIPEDCPPRLRNVIELCWSGDPKKRP 275 >3MY0-A nrPDB Length = 305 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 64/297 (21%), Positives = 108/297 (36%), Gaps = 41/297 (13%) Query: 26 NLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH--MKHENV 83 + VG G YG V G VAVK S + +RE + ++H+N+ Sbjct: 12 LVECVGKGRYGEVWRGLWH--GESVAVKIF-----SSRDEQSWFRETEIYNTVLLRHDNI 64 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHL-MGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIH 142 +G + + S ++L+TH L + ++ Q L L GL ++H Sbjct: 65 LGFIA--SDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLH 122 Query: 143 --------SADIIHRDLKPSNLAVNEDCELKILDFGLAR-------HTDDEMTGYVATRW 187 I HRD K N+ V + + I D GLA + D V T+ Sbjct: 123 VEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKR 182 Query: 188 YRAPEIMLNWMHYN-----QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 242 Y APE++ + + + DIW+ G ++ E+ RT+ G + + P Sbjct: 183 YMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA-RRTIVNGIVEDYRPPFYDVVPNDP 241 Query: 243 GAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITA 299 E +KK+ Q P + ++ + + R+TA Sbjct: 242 SFEDMKKVVC--------VDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTA 290 >4EUT-A nrPDB Length = 396 Score = 165 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 53/247 (21%), Positives = 99/247 (40%), Gaps = 29/247 (11%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAK 66 Q + +W + + +G GA +V KTG A+K + F + + Sbjct: 1 MGSQSTSNHLWLLSD------ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ 54 Query: 67 RTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ----KL 122 RE +LK + H+N++ L F + V ++ L +++ L Sbjct: 55 --MREFEVLKKLNHKNIVKL---FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGL 109 Query: 123 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLA--VNEDCE--LKILDFGLARHTDDE 178 + ++ ++ G+ ++ I+HR++KP N+ + ED + K+ DFG AR +D+ Sbjct: 110 PESEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD 169 Query: 179 --MTGYVATRWYRAPEIMLN-------WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI 229 T Y P++ Y TVD+WS+G TG F + Sbjct: 170 EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP 229 Query: 230 DQLKLIL 236 + K ++ Sbjct: 230 RRNKEVM 236 >3AOX-A nrPDB Length = 344 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 51/253 (20%), Positives = 92/253 (36%), Gaps = 30/253 (11%) Query: 19 EVPER-YQNLSPVGSGAYGSVCAAF-----DTKTGLRVAVKKLSRPFQSIIHAKRTYREL 72 EVP + + +G GA+G V + + L+VAVK L S E Sbjct: 43 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-EVCSEQDELDFLMEA 101 Query: 73 RLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK--------LTD 124 ++ H+N++ + V SL+ L+ + G DL + ++ + L Sbjct: 102 LIISKFNHQNIVRCIGV-----SLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAM 156 Query: 125 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN---EDCELKILDFGLARHTDDEMTG 181 + + I G +Y+ IHRD+ N + KI DFG+AR Sbjct: 157 LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY 216 Query: 182 YVA-----TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLI 235 + PE + + + D WS G ++ E+ + G +P + + L+ + Sbjct: 217 RKGGCAMLPVKWMPPEAFMEGI-FTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFV 275 Query: 236 LRLVGTPGAELLK 248 + Sbjct: 276 TSGGRMDPPKNCP 288 >4G3E-A nrPDB Length = 352 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 52/205 (25%), Positives = 87/205 (42%), Gaps = 23/205 (11%) Query: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 VG G++G V D +TG + AVKK+ + EL + ++ L Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVE-------ELVACAGLSSPRIVPLYG 133 Query: 89 VFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGLKYIHSADII 147 + F ++ L G L ++K L +D + + Q L GL+Y+H+ I+ Sbjct: 134 AVREGPWVNIFMEL-----LEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRIL 188 Query: 148 HRDLKPSNLAVNEDC-ELKILDFG--LARHTDDEMTGYV------ATRWYRAPEIMLNWM 198 H D+K N+ ++ D + DFG L D + T + APE+++ Sbjct: 189 HGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMG-K 247 Query: 199 HYNQTVDIWSVGCIMAELLTGRTLF 223 + VDIWS C+M +L G + Sbjct: 248 PCDAKVDIWSSCCMMLHMLNGCHPW 272 >2Y4I-B nrPDB Length = 319 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 62/308 (20%), Positives = 123/308 (39%), Gaps = 44/308 (14%) Query: 18 WEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 W++P E+ + +G G +G V VA++ + + K RE+ + Sbjct: 28 WDIPFEQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIERDNEDQLKAFKREVMAYR 84 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK--LTDDHVQFLIYQI 134 +HENV+ + L + G L ++V+ K L + + + +I Sbjct: 85 QTRHENVVLFMGACMSPPHLAIITSL-----CKGRTLYSVVRDAKIVLDVNKTRQIAQEI 139 Query: 135 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGL--------ARHTDDEMTGYVATR 186 ++G+ Y+H+ I+H+DLK N+ + + ++ I DFGL A +D++ Sbjct: 140 VKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWL 198 Query: 187 WYRAPEIM--------LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL 238 + APEI+ + + +++ D++++G I EL F + I+ Sbjct: 199 CHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFK----TQPAEAIIWQ 254 Query: 239 VGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT 298 +GT L +I + I F +D+LEK+ + +R++ Sbjct: 255 MGTGMKPNLSQIGMGKEISDILLFC----WAFEQEERPTFTKLMDMLEKLPKRN--RRLS 308 Query: 299 AAQALAHA 306 H Sbjct: 309 ------HP 310 >5XD6-A nrPDB Length = 305 Score = 164 bits (415), Expect = 7e-41, Method: Composition-based stats. Identities = 58/222 (26%), Positives = 96/222 (43%), Gaps = 28/222 (12%) Query: 19 EVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 ++ + Y + S +G G+YG V K+G A+KKL Q + ++ ++ + Sbjct: 19 DITDNYGSKSLIGEGSYGRVFYGI-LKSGKAAAIKKLDSSKQPD---QEFLAQVSMVSRL 74 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK----------LTDDHVQ 128 + ENV+ LL V + L++I+ +K L+ Sbjct: 75 RQENVVALLGYCVDGPL-----RVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRV 129 Query: 129 FLIYQILRGLKYIHSA---DIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-----EMT 180 + RGL+Y+H +IHRD+K SN+ + +D KI DF L+ D T Sbjct: 130 KIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHST 189 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTL 222 + T Y APE + + D++S G ++ ELLTGR Sbjct: 190 RVLGTFGYHAPEYAMTGTL-STKSDVYSFGVVLLELLTGRKP 230 >3SOC-A nrPDB Length = 322 Score = 163 bits (414), Expect = 8e-41, Method: Composition-based stats. Identities = 68/316 (21%), Positives = 125/316 (39%), Gaps = 44/316 (13%) Query: 4 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII 63 Y Q + + EV R G +G V A VAVK P Q Sbjct: 15 GTENLYFQSMPLQLLEVKAR---------GRFGCVWKAQLL--NEYVAVKIF--PIQDKQ 61 Query: 64 HAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHL-MGADLNNIVKCQKL 122 + Y E+ L MKHEN++ + S++ D++L+T L++ +K + Sbjct: 62 SWQNEY-EVYSLPGMKHENILQFIGAEKRGTSVDV--DLWLITAFHEKGSLSDFLKANVV 118 Query: 123 TDDHVQFLIYQILRGLKYIHS----------ADIIHRDLKPSNLAVNEDCELKILDFGLA 172 + + + + + RGL Y+H I HRD+K N+ + + I DFGLA Sbjct: 119 SWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLA 178 Query: 173 RHTD-----DEMTGYVATRWYRAPEIMLNWMHYNQ----TVDIWSVGCIMAELLTGRTLF 223 + + G V TR Y APE++ +++ + +D++++G ++ EL + T Sbjct: 179 LKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAA 238 Query: 224 PGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVD 283 G L + P E ++++ + + A + Sbjct: 239 DGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCET------- 291 Query: 284 LLEKMLVLDSDKRITA 299 +E+ D++ R++A Sbjct: 292 -IEECWDHDAEARLSA 306 >3ZZW-A nrPDB Length = 289 Score = 163 bits (414), Expect = 8e-41, Method: Composition-based stats. Identities = 59/293 (20%), Positives = 109/293 (37%), Gaps = 49/293 (16%) Query: 25 QNLSPVGSGAYGSVCAAF-----DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 + + +G +G V + VA+K L + + + E L ++ Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPL-REEFRHEAMLRARLQ 70 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-----------------L 122 H NV+ LL V T + L + ++ DL+ + + L Sbjct: 71 HPNVVCLLGVVTKDQPLS-----MIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSAL 125 Query: 123 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGL------ARHTD 176 L+ QI G++Y+ S ++H+DL N+ V + +KI D GL A + Sbjct: 126 EPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYK 185 Query: 177 DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLI 235 + RW APE ++ + ++ DIWS G ++ E+ + G + G + D +++I Sbjct: 186 LLGNSLLPIRW-MAPEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMI 243 Query: 236 LRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKM 288 P + A Y + N F P D+ ++ Sbjct: 244 RNRQVLPCPDDCP------AWVYALMIECW------NEFPSRRPRFKDIHSRL 284 >6O8B-A nrPDB Length = 665 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 53/244 (21%), Positives = 99/244 (40%), Gaps = 29/244 (11%) Query: 11 QELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTY 69 Q + +W + + +G GA +V KTG A+K + F + + Sbjct: 10 QSTSNHLWLLSD------ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--M 61 Query: 70 RELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ----KLTDD 125 RE +LK + H+N++ L F + V ++ L +++ L + Sbjct: 62 REFEVLKKLNHKNIVKL---FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPES 118 Query: 126 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLA--VNEDCE--LKILDFGLARHTDDE--M 179 ++ ++ G+ ++ I+HR++KP N+ + ED + K+ DFG AR +D+ Sbjct: 119 EFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF 178 Query: 180 TGYVATRWYRAPEIMLN-------WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQL 232 T Y P++ Y TVD+WS+G TG F + + Sbjct: 179 VELYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN 238 Query: 233 KLIL 236 K ++ Sbjct: 239 KEVM 242 >6NT9-A nrPDB Length = 742 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 53/244 (21%), Positives = 99/244 (40%), Gaps = 29/244 (11%) Query: 11 QELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTY 69 Q + +W + + +G GA +V KTG A+K + F + + Sbjct: 2 QSTSNHLWLLSD------ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--M 53 Query: 70 RELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ----KLTDD 125 RE +LK + H+N++ L F + V ++ L +++ L + Sbjct: 54 REFEVLKKLNHKNIVKL---FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPES 110 Query: 126 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLA--VNEDCE--LKILDFGLARHTDDE--M 179 ++ ++ G+ ++ I+HR++KP N+ + ED + K+ DFG AR +D+ Sbjct: 111 EFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF 170 Query: 180 TGYVATRWYRAPEIMLN-------WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQL 232 T Y P++ Y TVD+WS+G TG F + + Sbjct: 171 VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN 230 Query: 233 KLIL 236 K ++ Sbjct: 231 KEVM 234 >5TE0-A nrPDB Length = 347 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 65/350 (18%), Positives = 124/350 (35%), Gaps = 66/350 (18%) Query: 28 SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-HENVIGL 86 + G + V T G++ A+K++ + + RE+++++ + H+N++G Sbjct: 25 EVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEH--DLQVCKREIQIMRDLSGHKNIVGY 81 Query: 87 LDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQ---KLTDDHVQFLIYQILRGLKYIH 142 +D S + +V ++ G + N++ + T++ V + + +H Sbjct: 82 IDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLH 141 Query: 143 SAD--IIHRDLKPSNLAVNEDCELKILDFGLARH------------TDDEMTGYVATRWY 188 IIHRDLK N+ +++ + DFG A + +DE+ Y T Y Sbjct: 142 QCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYT-TLSY 200 Query: 189 RAPEI--MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 RAPE+ + + DIW++GC++ +L F Sbjct: 201 RAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF----------------------- 237 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHA 306 ES +P + + L+ ML D DKR Q + Sbjct: 238 -----GESQVAICDGNFTIPDNS------RYSQDMHCLIRYMLEPDPDKRPDIYQV---S 283 Query: 307 YFAQYHDPDDEPVAD----PYDQSFESRDLLIDEWKSLTYDEVISFVPPP 352 YF+ + P+ + P + T + P P Sbjct: 284 YFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIP 333 >3QD2-B nrPDB Length = 332 Score = 162 bits (409), Expect = 3e-40, Method: Composition-based stats. Identities = 65/351 (18%), Positives = 129/351 (36%), Gaps = 105/351 (29%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 ++ + +G G +G V A + A+K++ P + + ++ RE++ L ++H Sbjct: 7 DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELA-REKVMREVKALAKLEHPG 65 Query: 83 VIGLLDVF--TPARSLEEFND--------------------------------------- 101 ++ + + TP +E D Sbjct: 66 IVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVG 125 Query: 102 ----------VYLVTHLM-GADLNNIVKCQKLTDDH----VQFLIYQILRGLKYIHSADI 146 +Y+ L +L + + + +D + QI ++++HS + Sbjct: 126 QLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGL 185 Query: 147 IHRDLKPSNLAVNEDCELKILDFGLARHTDDE---------------MTGYVATRWYRAP 191 +HRDLKPSN+ D +K+ DFGL D + TG V T+ Y +P Sbjct: 186 MHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSP 245 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 E ++ +Y+ VDI+S+G I+ ELL + + ++++++I Sbjct: 246 E-QIHGNNYSHKVDIFSLGLILFELL-----YSFSTQMERVRII---------------- 283 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQA 302 T + + F +F P +++ ML +R A Sbjct: 284 -----------TDVRNLKFPLLFTQKYPQEHMMVQDMLSPSPTERPEATDI 323 >4FL3-A nrPDB Length = 635 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 49/234 (20%), Positives = 99/234 (42%), Gaps = 21/234 (8%) Query: 28 SPVGSGAYGSVCAAFD--TKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIG 85 +GSG +G+V + K VAVK L E +++ + + ++ Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 86 LLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQK-LTDDHVQFLIYQILRGLKYIHS 143 ++ + E LV + LN ++ + + D ++ L++Q+ G+KY+ Sbjct: 435 MIGIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 Query: 144 ADIIHRDLKPSNLAVNEDCELKILDFGLAR-------HTDDEMTGYVATRWYRAPEIMLN 196 ++ +HRDL N+ + KI DFGL++ + + G +WY APE + N Sbjct: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECI-N 545 Query: 197 WMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 + ++ D+WS G +M E + G+ + G + ++ + + Sbjct: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 599 >3UIM-A nrPDB Length = 326 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 49/215 (22%), Positives = 91/215 (42%), Gaps = 20/215 (9%) Query: 21 PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH 80 + + N + +G G +G V G VAVK+L + E+ ++ H Sbjct: 29 SDNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEERTQGGELQ-FQTEVEMISMAVH 86 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-----LTDDHVQFLIYQIL 135 N++ L + + ++ + + ++ + L Q + Sbjct: 87 RNLLRLRGFCMTPT-----ERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSA 141 Query: 136 RGLKYIHSA---DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE----MTGYVATRWY 188 RGL Y+H IIHRD+K +N+ ++E+ E + DFGLA+ D + T T + Sbjct: 142 RGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGH 201 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLF 223 APE + ++ D++ G ++ EL+TG+ F Sbjct: 202 IAPEYLSTGKS-SEKTDVFGYGVMLLELITGQRAF 235 >5IKW-A nrPDB Length = 310 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 67/339 (19%), Positives = 124/339 (36%), Gaps = 62/339 (18%) Query: 12 ELNKTIWEVPERYQNLSP-VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR 70 + ++ V L + G + +V T G+R A+K++ ++ R Sbjct: 3 SVGVRVFAVGRHQVTLEESLAEGGFSTVFLVR-THGGIRCALKRMY--VNNMPDLNVCKR 59 Query: 71 ELRLLKHMK-HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ---KLTDDH 126 E+ ++K + H+N++G LD + S + + L+ + + N + + T+ Sbjct: 60 EITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPE 119 Query: 127 VQFLIYQILRGLKYIHSAD--IIHRDLKPSNLAVNEDCELKILDFGLARH---------- 174 V + + +H IIHRDLK N+ +N+ + DFG A + Sbjct: 120 VLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGV 179 Query: 175 --TDDEMTGYVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHID 230 ++E+ Y T YRAPE++ DIW++GC++ +L F G + Sbjct: 180 NVVEEEIKKYT-TLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-GESQVA 237 Query: 231 QLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLV 290 + Y +++ L+ ML Sbjct: 238 ICD--------------GNFTIPDNSRYSRNIHC-------------------LIRFMLE 264 Query: 291 LDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFES 329 D + R Q +YFA D PV++ + S S Sbjct: 265 PDPEHRPDIFQV---SYFAFKFAAADCPVSNINNSSIPS 300 >4F9B-A nrPDB Length = 361 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 83/349 (23%), Positives = 135/349 (38%), Gaps = 71/349 (20%) Query: 24 YQNLSPVGSGAYGSVCAAF---DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK- 79 ++ +G G + SV A ++A+K L H R EL+ L Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTS----HPIRIAAELQCLTVAGG 78 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLK 139 +NV+G+ F + V + +L +I+ L+ V+ + + + LK Sbjct: 79 QDNVMGVKYCFRKNDHV-----VIAMPYLEHESFLDILNS--LSFQEVREYMLNLFKALK 131 Query: 140 YIHSADIIHRDLKPSNLAVNEDCE-LKILDFGLARHTDD--------------------- 177 IH I+HRD+KPSN N + ++DFGLA+ T D Sbjct: 132 RIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQN 191 Query: 178 ----------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFP-GT 226 ++ T +RAPE++ + +D+WS G I LL+GR F + Sbjct: 192 KCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKAS 251 Query: 227 DHIDQLKLILRLVG---------TPGAELL--KKISSESARNYIQSLTQMPKMNFA---- 271 D + L I+ + G T G +L K++ ++ R + L M Sbjct: 252 DDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSD 311 Query: 272 --------NVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYH 312 + A DLL+K+L L+ RITA +AL H +F Sbjct: 312 IQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMS 360 >2QKW-B nrPDB Length = 321 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 123/306 (40%), Gaps = 36/306 (11%) Query: 9 YRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRT 68 YR L + E + + +G G +G V + G +VA+K+ R +S + Sbjct: 27 YRVPL-VDLEEATNNFDHKFLIGHGVFGKVYKGV-LRDGAKVALKR--RTPESSQGIEEF 82 Query: 69 YRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKL----- 122 E+ L +H +++ L+ +E N++ L+ M +L + L Sbjct: 83 ETEIETLSFCRHPHLVSLIGFC------DERNEMILIYKYMENGNLKRHLYGSDLPTMSM 136 Query: 123 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY 182 + + + RGL Y+H+ IIHRD+K N+ ++E+ KI DFG+++ + + Sbjct: 137 SWEQRLEICIGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTH 196 Query: 183 V-----ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 + T Y PE + + D++S G ++ E+L R+ + + + L Sbjct: 197 LSTVVKGTLGYIDPEYFIKGRL-TEKSDVYSFGVVLFEVLCARSAIVQSLPREMVNLAEW 255 Query: 238 LVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI 297 V + L++I + + I+ + D K L L S+ R Sbjct: 256 AVESHNNGQLEQIVDPNLADKIR--------------PESLRKFGDTAVKCLALSSEDRP 301 Query: 298 TAAQAL 303 + L Sbjct: 302 SMGDVL 307 >5C26-A nrPDB Length = 299 Score = 158 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 49/234 (20%), Positives = 99/234 (42%), Gaps = 21/234 (8%) Query: 28 SPVGSGAYGSVCAAFD--TKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIG 85 +GSG +G+V + K VAVK L E +++ + + ++ Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 86 LLDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQK-LTDDHVQFLIYQILRGLKYIHS 143 ++ + E LV + LN ++ + + D ++ L++Q+ G+KY+ Sbjct: 93 MIGIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 145 Query: 144 ADIIHRDLKPSNLAVNEDCELKILDFGLAR-------HTDDEMTGYVATRWYRAPEIMLN 196 ++ +HRDL N+ + KI DFGL++ + + G +WY APE + N Sbjct: 146 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECI-N 203 Query: 197 WMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 + ++ D+WS G +M E + G+ + G + ++ + + Sbjct: 204 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 257 >5WNO-A nrPDB Length = 330 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 56/278 (20%), Positives = 105/278 (37%), Gaps = 33/278 (11%) Query: 25 QNLSPVGSGAYGSVCAAFD-----TKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 + +G+GA+G+V A + VA+K E + ++ Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQ---TDQSQTDEMLEEATNMFRLR 81 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK--LTDDHVQFLIYQILRG 137 H+N++ ++ + + + + +L N +K K L YQI G Sbjct: 82 HDNLLKIIGFC-----MHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASG 136 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRAP 191 ++Y+ ++HRDL N+ V + ++I DFGL++ + +G VA +W A Sbjct: 137 MQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKW-LAI 195 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPG--TDHIDQLKLILRLVGTPGAELLK 248 EI Y D+W+ G E++T G++ + G TD I + P Sbjct: 196 EIFSKHC-YTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQP-----P 249 Query: 249 KISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLE 286 S + + ++ PK F + + Sbjct: 250 NCSQDLYQELLRCWMADPKSRPG--FEILYERFKEFCK 285 >4M66-A nrPDB Length = 325 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 57/251 (22%), Positives = 108/251 (43%), Gaps = 29/251 (11%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 E + L VG G +G V A VAVK + ++K+ E++ + ++++E Sbjct: 20 EELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIV--------NSKKISWEVKAMVNLRNE 71 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ-KLTDDHVQFLIYQILRGLKY 140 NV+ LL V + + + L +++ + + L+ +++ G+ Y Sbjct: 72 NVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCY 131 Query: 141 IHS--ADIIHRDLKPSNLAVNEDCELKILDFGLAR---------HTDDEMTGYVATRWYR 189 +HS ++HRDLKPSN+ ++ + K+ DFGL+ + T Y Sbjct: 132 LHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYL 191 Query: 190 APEIMLN-WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGT----PGA 244 PE++ + ++ D++S G ++ +L GR + +D+ LI V P Sbjct: 192 DPELLFKVNLKASKASDVYSFGILVWAVLAGRE----AELVDKTSLIRETVCDRQSRPPL 247 Query: 245 ELLKKISSESA 255 L S E+ Sbjct: 248 TELPPGSPETP 258 >3G2F-A nrPDB Length = 336 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 63/309 (20%), Positives = 111/309 (35%), Gaps = 44/309 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK--HMK 79 + + L +G G YG+V + VAVK S + + E + + M+ Sbjct: 13 DNLKLLELIGRGRYGAVYKG--SLDERPVAVKVF-----SFANRQNFINEKNIYRVPLME 65 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLK 139 H+N+ + + + ++ + L + L + + RGL Sbjct: 66 HDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLA 125 Query: 140 YIH---------SADIIHRDLKPSNLAVNEDCELKILDFGLARHT-----------DDEM 179 Y+H I HRDL N+ V D I DFGL+ D+ Sbjct: 126 YLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAA 185 Query: 180 TGYVATRWYRAPEIMLN------WMHYNQTVDIWSVGCIMAELLTGRT-LFPGTDHID-Q 231 V T Y APE++ + VD++++G I E+ T LFPG + Q Sbjct: 186 ISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQ 245 Query: 232 LKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVL 291 + + P E ++ + S + + P+ N + + +E Sbjct: 246 MAFQTEVGNHPTFEDMQVLVSREKQR-----PKFPEAWKENSLAVRS--LKETIEDCWDQ 298 Query: 292 DSDKRITAA 300 D++ R+TA Sbjct: 299 DAEARLTAQ 307 >5CEK-A nrPDB Length = 263 Score = 154 bits (390), Expect = 5e-38, Method: Composition-based stats. Identities = 57/280 (20%), Positives = 105/280 (37%), Gaps = 51/280 (18%) Query: 38 VCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLE 97 V A TG + K P + R Y ++L H N+ G+++V Sbjct: 25 VSRALCIHTGRELRCKVF--PIKHYQDKIRPY--IQL---PSHSNITGIVEVILGE---- 73 Query: 98 EFNDVYLVTHLMGADLNNIVKCQ-KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNL 156 Y+ D+++ V+ + +L ++ L QI+ + + H + I+ DLK Sbjct: 74 --TKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKF 131 Query: 157 AVN--EDCELKIL---DFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYN-QTVDIWSVG 210 + E +L++ D + + DD ++ Y +PEI+ Y+ + D+WS+G Sbjct: 132 VFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLG 191 Query: 211 CIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNF 270 ++ LL GR F +D I R + Sbjct: 192 VMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHI------------------------ 227 Query: 271 ANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 +P A L+ +L + +R+TA + L H +F Sbjct: 228 -------SPKARCLIRSLLRREPSERLTAPEILLHPWFES 260 >6DC0-A nrPDB Length = 292 Score = 154 bits (390), Expect = 5e-38, Method: Composition-based stats. Identities = 57/280 (20%), Positives = 105/280 (37%), Gaps = 51/280 (18%) Query: 38 VCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLE 97 V A TG + K P + R Y ++L H N+ G+++V Sbjct: 22 VSRALCIHTGRELRCKVF--PIKHYQDKIRPY--IQL---PSHSNITGIVEVILGE---- 70 Query: 98 EFNDVYLVTHLMGADLNNIVKCQ-KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNL 156 Y+ D+++ V+ + +L ++ L QI+ + + H + I+ DLK Sbjct: 71 --TKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKF 128 Query: 157 AVN--EDCELKIL---DFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYN-QTVDIWSVG 210 + E +L++ D + + DD ++ Y +PEI+ Y+ + D+WS+G Sbjct: 129 VFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLG 188 Query: 211 CIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNF 270 ++ LL GR F +D I R + Sbjct: 189 VMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHI------------------------ 224 Query: 271 ANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310 +P A L+ +L + +R+TA + L H +F Sbjct: 225 -------SPKARCLIRSLLRREPSERLTAPEILLHPWFES 257 >5VC6-A nrPDB Length = 289 Score = 153 bits (388), Expect = 9e-38, Method: Composition-based stats. Identities = 53/309 (17%), Positives = 103/309 (33%), Gaps = 64/309 (20%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM-KHE 81 + L +GSG +GSV G A+K+ +P + + RE+ + +H Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 71 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK-----LTDDHVQFLIYQILR 136 +V+ + + N + G L + + + ++ L+ Q+ R Sbjct: 72 HVVRYFSAWAEDDHMLIQN-----EYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGR 126 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCEL-------------------KILDFGLARHTDD 177 GL+YIHS ++H D+KPSN+ ++ KI D G Sbjct: 127 GLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISS 186 Query: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 + A E++ + DI+++ + G P + DQ I + Sbjct: 187 PQVEE-GDSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLP--RNGDQWHEIRQ 242 Query: 238 LVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI 297 + + +LL+ M+ D ++R Sbjct: 243 ------------------------------GRLPRIPQVLSQEFTELLKVMIHPDPERRP 272 Query: 298 TAAQALAHA 306 +A + H+ Sbjct: 273 SAMALVKHS 281 >2H34-A nrPDB Length = 309 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 65/219 (29%), Positives = 99/219 (45%), Gaps = 18/219 (8%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS-IIHAKRTYRELRLLKHMKHEN 82 Y+ VG G G V A DT VA+K +S S + R RE R ++ + Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQK-LTDDHVQFLIYQILRGLKY 140 V+ + D E +Y+ L+ DL +++ Q L ++ QI L Sbjct: 96 VVPIHDF------GEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDA 149 Query: 141 IHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY----VATRWYRAPEIMLN 196 H+A HRD+KP N+ V+ D ++DFG+A T DE V T +Y APE + Sbjct: 150 AHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERF-S 208 Query: 197 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLI 235 H DI+++ C++ E LTG + G DQL ++ Sbjct: 209 ESHATYRADIYALTCVLYECLTGSPPYQG----DQLSVM 243 >5E8V-A nrPDB Length = 316 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 60/303 (19%), Positives = 120/303 (39%), Gaps = 42/303 (13%) Query: 25 QNLSPVGSGAYGSVCAAFDTKTG----LRVAVKKLS-RPFQSIIHAKRTYRELRLLKHMK 79 + + VG G + V A + VAVK + S K + ++ +K Sbjct: 12 ELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDIN----LK 67 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHL-MGADLNNIVKCQKLTDDHVQFLIYQILRGL 138 HEN++ L R E +L+T +L + ++ + ++ L + RG+ Sbjct: 68 HENILQFLTA--EERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGI 125 Query: 139 KYIHS---------ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM-------TGY 182 ++HS I+HRDLK SN+ V D + DFGL+ D + +G Sbjct: 126 AHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQ 185 Query: 183 VATRWYRAPEIMLNWMHYN-----QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 V T Y APE++ + M+ + D++S+ ++ E+ + + + + Sbjct: 186 VGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRC---------NAVGEVKD 236 Query: 238 LVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI 297 G+++ + S + + + P++ + + + L + D + R+ Sbjct: 237 YEPPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARL 296 Query: 298 TAA 300 TA Sbjct: 297 TAQ 299 >5VDK-A nrPDB Length = 297 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 59/312 (18%), Positives = 113/312 (36%), Gaps = 69/312 (22%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM-KH 80 + + + +G G +G+V G A+K+ + F + + E+ + H Sbjct: 15 KEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHH 74 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-----NNIVKCQKLTDDHVQFLIYQIL 135 +V+ + + N + G L N + ++ ++ QI Sbjct: 75 PHVVRYYSSWAEDDHMIIQN-----EYCNGGSLQAAISENTKSGNHFEEPKLKDILLQIS 129 Query: 136 RGLKYIHSADIIHRDLKPSNL-----------------------AVNEDCELKILDFGLA 172 GL YIH++ ++H D+KPSN+ ++ + KI D G A Sbjct: 130 LGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHA 189 Query: 173 RHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQL 232 + + A EI+ + DI+++G Sbjct: 190 TSINKPKVEE-GDSRFLANEILQEDYRHLPKADIFALGLT-------------------- 228 Query: 233 KLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLD 292 + GAE L ++ +A ++I+ K NF +V + LL+ M+ D Sbjct: 229 -----IAVAAGAESLP--TNGAAWHHIR------KGNFPDVPQELSESFSSLLKNMIQPD 275 Query: 293 SDKRITAAQALA 304 +++R +AA ALA Sbjct: 276 AEQRPSAA-ALA 286 >5AR8-A nrPDB Length = 326 Score = 150 bits (379), Expect = 8e-37, Method: Composition-based stats. Identities = 65/326 (19%), Positives = 122/326 (37%), Gaps = 41/326 (12%) Query: 5 RPTFYRQELNKTIW-----EVPE-RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLS-R 57 + Y Q +N +P + +L + GA G+V +A ++VAVK L Sbjct: 9 KENLYFQGMNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIH 68 Query: 58 PFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNI 116 K RE +L + ++ +L + L +VT M LN + Sbjct: 69 TPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLG------IVTEYMPNGSLNEL 122 Query: 117 VKCQKLTDDHVQ----FLIYQILRGLKYIHSA--DIIHRDLKPSNLAVNEDCELKILDFG 170 + + D ++++I G+ Y+H+ ++H DLK N+ ++ + +KI DFG Sbjct: 123 LHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFG 182 Query: 171 LAR--------HTDDEMTGYVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLTGR 220 L++ + T Y PE + DI+S I E+L+ + Sbjct: 183 LSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRK 242 Query: 221 TLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPL 280 F + L+++ + I+ ES I +M + + + Sbjct: 243 QPFEDVTNP------LQIMYSVSQGHRPVINEESLPYDIPHRARMISL-IESGWAQNPDE 295 Query: 281 AVDLLEKMLVLDSDKR----ITAAQA 302 L+ ++ L+ R IT +A Sbjct: 296 RPSFLKCLIELEPVLRTFEEITFLEA 321 >4LQP-A nrPDB Length = 508 Score = 148 bits (375), Expect = 3e-36, Method: Composition-based stats. Identities = 38/163 (23%), Positives = 68/163 (41%), Gaps = 9/163 (5%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ-SIIHAKRTYRELRLLKHMKH 80 E + + +G GA+G V TG A+K L + E +L Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 81 ENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNN-IVKCQKLTDDHVQFLIYQILRGL 138 V+ L F ++ +YL+ + G DL +++ Q T+D +F + + + + Sbjct: 162 PWVVSLYYSF------QDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAI 215 Query: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG 181 + IH IHR +KP N+ ++ +K+ DFGL+ Sbjct: 216 ETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDS 258 Score = 85.3 bits (210), Expect = 4e-17, Method: Composition-based stats. Identities = 37/166 (22%), Positives = 61/166 (36%), Gaps = 37/166 (22%) Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 242 V T Y APEI L + Y Q D WS+G IM E L G F + + I+ Sbjct: 324 VGTPDYIAPEIFL-YQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMN----- 377 Query: 243 GAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI----T 298 + Q P I + A DL+ ++L +D+R+ Sbjct: 378 ----------------FEQTLQFPDD------IHISYEAEDLIRRLLTH-ADQRLGRHGG 414 Query: 299 AAQALAHAYFA--QYHDP--DDEPVADPYDQSFESRDLLIDEWKSL 340 A + +H +F ++ + P ++R DE +++ Sbjct: 415 ADEIKSHPFFRGVDWNTIRQVEAPYIPKLSSITDTRFFPTDELENV 460 >4TN6-A nrPDB Length = 318 Score = 148 bits (374), Expect = 3e-36, Method: Composition-based stats. Identities = 65/275 (23%), Positives = 114/275 (41%), Gaps = 31/275 (11%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 V RY+ +GSG++G + D G VA+K + + E ++ K M+ Sbjct: 5 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKL----ECVKTKHPQLHIESKIYKMMQ 60 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIYQILRG 137 G + + T E + +V L+G L ++ +K + V L Q++ Sbjct: 61 -----GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISR 115 Query: 138 LKYIHSADIIHRDLKPSNLAVN---EDCELKILDFGLARHTDDEMT----------GYVA 184 ++YIHS + IHRD+KP N + + + I+DFGLA+ D T Sbjct: 116 IEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTG 175 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL----VG 240 T Y + L ++ D+ S+G ++ G + G + + R+ + Sbjct: 176 TARYASINTHLGIEQ-SRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMS 234 Query: 241 TPGAELLKKISSESAR--NYIQSLTQMPKMNFANV 273 TP L K SE A N+ +SL K +++ + Sbjct: 235 TPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYL 269 >2CHL-A nrPDB Length = 351 Score = 147 bits (371), Expect = 8e-36, Method: Composition-based stats. Identities = 58/306 (18%), Positives = 112/306 (36%), Gaps = 38/306 (12%) Query: 4 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII 63 Y Q + + V ++ +G G +G + + T VA+K Sbjct: 14 GTENLYFQSMG--VLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKL----EPMKS 67 Query: 64 HAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK--CQK 121 A + + E R K + + I + F P +V L+G L ++ + Sbjct: 68 RAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRT 122 Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE-----LKILDFGLARHTD 176 + V + Q++ ++Y+HS ++I+RD+KP N + + I+DF LA+ Sbjct: 123 FSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYI 182 Query: 177 D----------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPG- 225 D E T Y + L ++ D+ ++G + L G + G Sbjct: 183 DPETKKHIPYREHKSLTGTARYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGL 241 Query: 226 --TDHIDQLKLILRLVGTPGAELLKKISSESAR--NYIQSLTQMPKMNFANVFIGANPLA 281 ++ + I E+L + E A Y++ L K ++ + L Sbjct: 242 KADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYL----RKLF 297 Query: 282 VDLLEK 287 DL ++ Sbjct: 298 TDLFDR 303 >3SV0-A nrPDB Length = 483 Score = 146 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 53/289 (18%), Positives = 111/289 (38%), Gaps = 35/289 (12%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 V +++ +GSG++G + + +T VA+K + + + E ++ + ++ Sbjct: 5 VGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHP----QLLYESKIYRILQ 60 Query: 80 H----ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIYQ 133 N + V E + LV L+G L ++ +KL+ V L Q Sbjct: 61 GGTGIPN-VRWFGV--------EGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQ 111 Query: 134 ILRGLKYIHSADIIHRDLKPSNLAVN---EDCELKILDFGLARHTDDEMT---------- 180 ++ ++++HS +HRD+KP N + ++ I+DFGLA+ D T Sbjct: 112 MINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENK 171 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240 T Y + L ++ D+ S+G ++ L G + G + + ++ Sbjct: 172 NLTGTARYASVNTHLGIEQ-SRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISE 230 Query: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFAN--VFIGANPLAVDLLEK 287 A ++ + + + F + + L DL + Sbjct: 231 KKVATSIEALCRGYPTEFASYFHYCRSLRFDDKPDYSYLKRLFRDLFIR 279 >6BFN-A nrPDB Length = 342 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 46/213 (21%), Positives = 76/213 (35%), Gaps = 29/213 (13%) Query: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSR--PFQSIIHAKRTYRELRLLKHMKHENVIGL 86 +G G +G V A T AVK+L + + E+ L +H N++ Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 87 LDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ-----KLTDDHVQFLIYQILRGLKYI 141 + L L + + CQ L+ ++ R ++++ Sbjct: 87 AGYCAQNGFY-----CLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFL 141 Query: 142 H--SADIIHRDLKPSNLAVNEDCELKILDFGLARH------------TDDEMTGYVATRW 187 H S +IH D+K SN+ ++E K+ DFGLAR T Sbjct: 142 HQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLA 201 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGR 220 Y PE + D +S G ++ E L G+ Sbjct: 202 YL-PEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >4BTK-A nrPDB Length = 337 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 69/289 (23%), Positives = 116/289 (40%), Gaps = 35/289 (12%) Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60 MS N V +R++ L +G G +G + A D T VA+K + Sbjct: 38 MSGGGEQADILPANYV---VKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV-----E 89 Query: 61 SIIHAKRTYR-ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC 119 S K+ + E+ +LK ++ ++ V Y+V L G +L ++ + Sbjct: 90 SAQQPKQVLKMEVAVLKKLQGKD-----HVCRFIGCGRNEKFNYVVMQLQGRNLADLRRS 144 Query: 120 QK---LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNL----AVNEDCELKILDFGLA 172 Q T L QIL ++ IHS +HRD+KPSN + + +LDFGLA Sbjct: 145 QPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLA 204 Query: 173 RHTDD---------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLF 223 R + + G+ T Y + N + D+WS+ ++ E G+ + Sbjct: 205 RQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPW 263 Query: 224 PGTDHIDQLKLILRLVGTPGAELLKKISSE--SARNYIQSLTQMPKMNF 270 +Q+ +I LLK + SE ++I SL K ++ Sbjct: 264 RKIKDKEQVGMIKEKYE--HRMLLKHMPSEFHLFLDHIASLDYFTKPDY 310 >2QLU-A nrPDB Length = 314 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 61/289 (21%), Positives = 115/289 (39%), Gaps = 36/289 (12%) Query: 32 SGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFT 91 G +G V A VAVK + ++ RE+ MKHEN++ + Sbjct: 25 RGRFGCVWKAQLMND--FVAVKIFPLQDKQSWQSE---REIFSTPGMKHENLLQFIAAEK 79 Query: 92 PARSLEEFNDVYLVTHLMG-ADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS------- 143 +LE +++L+T L + +K +T + + + + RGL Y+H Sbjct: 80 RGSNLEV--ELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRG 137 Query: 144 ----ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-----EMTGYVATRWYRAPEIM 194 I HRD K N+ + D + DFGLA + + G V TR Y APE++ Sbjct: 138 EGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVL 197 Query: 195 LNWMHYNQ----TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250 +++ + +D++++G ++ EL++ G L + P E L+++ Sbjct: 198 EGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEV 257 Query: 251 SSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITA 299 + A + + +E+ D++ R++A Sbjct: 258 VVHKKMRPTIKDHWLKHPGLAQLCVT--------IEECWDHDAEARLSA 298 >3LMG-A nrPDB Length = 344 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 48/228 (21%), Positives = 96/228 (42%), Gaps = 22/228 (9%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLR----VAVKKLSRPFQSIIHAKRTYRELRLLKHM 78 + L +GSG +G+V G V +K + T L + + Sbjct: 32 ELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAI-GSL 90 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQK-LTDDHVQFLIYQIL 135 H +++ LL + P SL+ LVT + G+ L+++ + + L + QI Sbjct: 91 DHAHIVRLLGLC-PGSSLQ------LVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIA 143 Query: 136 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW-----YRA 190 +G+ Y+ ++HR+L N+ + ++++ DFG+A + + + + A Sbjct: 144 KGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMA 203 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILR 237 E + ++ Y D+WS G + EL+T G + G + L+ + Sbjct: 204 LESI-HFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEK 250 >4NFN-A nrPDB Length = 309 Score = 144 bits (364), Expect = 5e-35, Method: Composition-based stats. Identities = 69/289 (23%), Positives = 116/289 (40%), Gaps = 35/289 (12%) Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60 MS N V +R++ L +G G +G + A D T VA+K + Sbjct: 3 MSGGGEQADILPANYV---VKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV-----E 54 Query: 61 SIIHAKRTYR-ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC 119 S K+ + E+ +LK ++ ++ V Y+V L G +L ++ + Sbjct: 55 SAQQPKQVLKMEVAVLKKLQGKD-----HVCRFIGCGRNEKFNYVVMQLQGRNLADLRRS 109 Query: 120 QK---LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNL----AVNEDCELKILDFGLA 172 Q T L QIL ++ IHS +HRD+KPSN + + +LDFGLA Sbjct: 110 QPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLA 169 Query: 173 RHTDD---------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLF 223 R + + G+ T Y + N + D+WS+ ++ E G+ + Sbjct: 170 RQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPW 228 Query: 224 PGTDHIDQLKLILRLVGTPGAELLKKISSE--SARNYIQSLTQMPKMNF 270 +Q+ +I LLK + SE ++I SL K ++ Sbjct: 229 RKIKDKEQVGMIKEKYE--HRMLLKHMPSEFHLFLDHIASLDYFTKPDY 275 >5J0A-A nrPDB Length = 300 Score = 143 bits (362), Expect = 8e-35, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 114/306 (37%), Gaps = 47/306 (15%) Query: 26 NLSPVGSGAYGS---VCAAFDTKTGLRV---AVKKLS---RPFQSIIHAKRTYRELRLLK 76 + +G +G+ V + GL AVKK++ ++ KR E ++LK Sbjct: 13 FMQKLG---FGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILK 69 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQ------KLTDDHVQF 129 + H N++G FT A + L G LN++++ + + Sbjct: 70 SLHHPNIVG-YRAFTEA----NDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILK 124 Query: 130 LIYQILRGLKYIHS-ADIIHRDLKPSNLAVNEDC-ELKILDFGLARHTDDEM------TG 181 + + RGLKY+H ++H D+K SN+ + D +KI D G++ D+ M Sbjct: 125 VALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEAC 184 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGT 241 Y+ T ++ E + DI++ G + E++T HI+ T Sbjct: 185 YIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP-----HINLSNDDDDEDKT 239 Query: 242 PGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA- 300 Y +L P +N + ++L D R +AA Sbjct: 240 FDESDFDD------EAYYAALGTRPPIN-MEELDESYQKVIELFSVCTNEDPKDRPSAAH 292 Query: 301 --QALA 304 +AL Sbjct: 293 IVEALE 298 >5L2Q-C nrPDB Length = 320 Score = 141 bits (356), Expect = 4e-34, Method: Composition-based stats. Identities = 54/304 (17%), Positives = 112/304 (36%), Gaps = 67/304 (22%) Query: 39 CAAFDTKTGLRVAVKKLSRPFQSIIHAKR---------TYRELRLLKHMKHEN-VIGLLD 88 C A T +K L+ + + + E LL + ++ V+ Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 89 VFTPARS------------LEEFNDVYLVTHLM--------GADL----NNIVKCQKLTD 124 +F + + LV + ADL + ++K ++L++ Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 125 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE-LKILDFGLARHT---DDEMT 180 + Y ++R ++ +H +I+HRDLK N+ +N+ + I +F L +H D + Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240 + Y +P+++ + + D+W++G ++ +L G+ F + + + I Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEY 272 Query: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300 T + + V L+ K+LVLD +R+ AA Sbjct: 273 TIPED-----------------------------GRVSENTVCLIRKLLVLDPQQRLAAA 303 Query: 301 QALA 304 L Sbjct: 304 DVLE 307 >5FQD-C nrPDB Length = 341 Score = 141 bits (355), Expect = 5e-34, Method: Composition-based stats. Identities = 62/272 (22%), Positives = 111/272 (40%), Gaps = 31/272 (11%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 V +Y+ + +GSG++G + A + G VAVK Q H + Y E +L K ++ Sbjct: 17 VGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVK---LESQKARHPQLLY-ESKLYKILQ 72 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIYQILRG 137 G + + +E + LV L+G L ++ ++ T V L Q++ Sbjct: 73 -----GGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISR 127 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCEL---KILDFGLARHTDDEMT----------GYVA 184 ++Y+H+ + IHRD+KP N + ++DFGLA+ D T Sbjct: 128 IEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTG 187 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPG---TDHIDQLKLI-LRLVG 240 T Y + L ++ D+ S+G ++ + G + + I + + Sbjct: 188 TARYASINAHLGIEQ-SRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMS 246 Query: 241 TPGAELLKKISSESA--RNYIQSLTQMPKMNF 270 TP L K +E A NY + L ++ Sbjct: 247 TPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDY 278 >2C47-A nrPDB Length = 313 Score = 140 bits (354), Expect = 6e-34, Method: Composition-based stats. Identities = 62/289 (21%), Positives = 111/289 (38%), Gaps = 39/289 (13%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 ++ +G G +G + + T VA+K P +S A + + E R K + Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK--LEPIKS--RAPQLHLEYRFYKQLSATE 60 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIYQILRGLKY 140 + + F P +V L+G L ++ + T V + Q++ ++Y Sbjct: 61 GVPQVYYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEY 115 Query: 141 IHSADIIHRDLKPSNLAVNEDCE-----LKILDFGLARHTDD----------EMTGYVAT 185 +H+ +I+RD+KP N V + I+DFGLA+ D E T Sbjct: 116 VHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGT 175 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG----- 240 Y + L ++ D+ ++G + L G + G D LK + +G Sbjct: 176 ARYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDTKRA 233 Query: 241 TPGAELLKKISSESAR--NYIQSLTQMPKMNFANVFIGANPLAVDLLEK 287 TP L + E A Y++ L K ++ + L DL ++ Sbjct: 234 TPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYL----RKLFTDLFDR 278 >2CMW-A nrPDB Length = 310 Score = 139 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 65/288 (22%), Positives = 111/288 (38%), Gaps = 40/288 (13%) Query: 25 QNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN-V 83 + +G G +G + + T VA+K P +S A + + E R K + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK--LEPIKS--RAPQLHLEYRFYKQLGSAGEG 58 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIYQILRGLKYI 141 + + F P +V L+G L ++ + T V + Q+L ++Y+ Sbjct: 59 LPQVYYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYV 113 Query: 142 HSADIIHRDLKPSNLAVNEDCE-----LKILDFGLARHTDD----------EMTGYVATR 186 HS ++I+RD+KP N + + I+DFGLA+ D E T Sbjct: 114 HSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTA 173 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG-----T 241 Y + L ++ D+ ++G + L G + G D LK + +G T Sbjct: 174 RYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDTKRNT 231 Query: 242 PGAELLKKISSESAR--NYIQSLTQMPKMNFANVFIGANPLAVDLLEK 287 P L + E A Y++ L K ++ + L DL EK Sbjct: 232 PIEALCENFPEEMATYLRYVRRLDFFEKPDYEYL----RTLFTDLFEK 275 >4M69-B nrPDB Length = 283 Score = 138 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 46/234 (19%), Positives = 102/234 (43%), Gaps = 19/234 (8%) Query: 36 GSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRT--YRELRLLKHMKHENVIGLLDVFTPA 93 ++ ++ V +K + P + R E++ +K N++ + + Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICI-D 79 Query: 94 RSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGLKYIHSADIIHRDLK 152 ++++ ++ + L ++ +K LT L+ + RGL +H ++ +HR++ Sbjct: 80 QTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNIS 139 Query: 153 PSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW-------YRAPEIMLN-WMHYNQTV 204 S+ V ++K+ F L++ + +T+ Y +PE + N + Y+ Sbjct: 140 SSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKA 199 Query: 205 DIWSVGCIMAELLTGRTLFPGTDHIDQLKLI-----LRLVGTPGAELLKKISSE 253 +I+S G ++ E+ TG+ F G D +L+ VG ELL++I +E Sbjct: 200 EIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINE 253 >4BTF-A nrPDB Length = 469 Score = 138 bits (348), Expect = 3e-33, Method: Composition-based stats. Identities = 46/234 (19%), Positives = 102/234 (43%), Gaps = 19/234 (8%) Query: 36 GSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRT--YRELRLLKHMKHENVIGLLDVFTPA 93 ++ ++ V +K + P + R E++ +K N++ + + Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICI-D 265 Query: 94 RSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGLKYIHSADIIHRDLK 152 ++++ ++ + L ++ +K LT L+ + RGL +H ++ +HR++ Sbjct: 266 QTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNIS 325 Query: 153 PSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW-------YRAPEIMLN-WMHYNQTV 204 S+ V ++K+ F L++ + +T+ Y +PE + N + Y+ Sbjct: 326 SSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKA 385 Query: 205 DIWSVGCIMAELLTGRTLFPGTDHIDQLKLI-----LRLVGTPGAELLKKISSE 253 +I+S G ++ E+ TG+ F G D +L+ VG ELL++I +E Sbjct: 386 EIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINE 439 >4NT4-A nrPDB Length = 312 Score = 135 bits (339), Expect = 4e-32, Method: Composition-based stats. Identities = 52/293 (17%), Positives = 106/293 (36%), Gaps = 37/293 (12%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM- 78 V ++ +G G +G + + VA+K A + + E R K + Sbjct: 10 VGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKM----EPMKSKAPQLHLEYRFYKLLG 65 Query: 79 KH----ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIY 132 H + I ++ +N +V L+G L ++ +K + V + Sbjct: 66 SHADNAPDGIP--RIYHLGTCGGRYNA--MVLELLGLSLEDLFNICARKFSLKTVLMIAK 121 Query: 133 QILRGLKYIHSADIIHRDLKPSNLAVNEDCE-----LKILDFGLARHTDD---------- 177 Q+L ++Y+HS +I+RD+KP N + + I+DFGLA+ D Sbjct: 122 QLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYR 181 Query: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 E T Y + + ++ D+ ++G + L G + G + + Sbjct: 182 EHKSLTGTARYMSINTHMGREQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQK 240 Query: 238 LVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLV 290 + T A ++ + + L + +++F D L ++ Sbjct: 241 IGDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPD------YDFLRRLFQ 287 >4XHH-A nrPDB Length = 403 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 57/283 (20%), Positives = 104/283 (36%), Gaps = 29/283 (10%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 V +++ +GSG++G + + +G VA+ H + Y E R+ K++ Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQLDY-ESRVYKYLS 60 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIYQILRG 137 I + F +V L+G L ++ +K + V L Q++ Sbjct: 61 GGVGIPFIRWFGREGEYNA-----MVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICR 115 Query: 138 LKYIHSADIIHRDLKPSNLAVN---EDCELKILDFGLARHTDD----------EMTGYVA 184 ++YIH IHRD+KP N + + ++DFGL++ D E Sbjct: 116 VQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTG 175 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPG---TDHIDQLKLILRLVGT 241 T Y + L ++ D+ S+G ++ G + G T + IL Sbjct: 176 TARYASVNTHLGIEQ-SRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLC 234 Query: 242 PGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDL 284 E L Y+ + + K + ++ L DL Sbjct: 235 ISVETLCAGLPLEFSEYM-NYCRNLKFDERPDYLYLARLFKDL 276 >4XHL-A nrPDB Length = 394 Score = 128 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 54/283 (19%), Positives = 104/283 (36%), Gaps = 29/283 (10%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 V +++ +GSG++G + + +G VA+ H + Y E R+ +++ Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQLDY-ESRVYRYLS 60 Query: 80 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIYQILRG 137 I + F +V L+G L ++ ++ + V L Q+ Sbjct: 61 GGVGIPFIRWFGREGEYNA-----MVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCR 115 Query: 138 LKYIHSADIIHRDLKPSNLAVN---EDCELKILDFGLARHTDD----------EMTGYVA 184 ++YIH IHRD+KP N + + ++DFGL++ D E Sbjct: 116 IQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTG 175 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPG---TDHIDQLKLILRLVGT 241 T Y + L ++ D+ S+G ++ G + G T + I+ Sbjct: 176 TARYASVNTHLGIEQ-SRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLN 234 Query: 242 PGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDL 284 E L + Y+ + + K + ++ L DL Sbjct: 235 VSVETLCSGLPLEFQEYM-AYCKNLKFDEKPDYLFLARLFKDL 276 >3VHK-A nrPDB Length = 368 Score = 128 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 42/183 (22%), Positives = 80/183 (43%), Gaps = 21/183 (11%) Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-DDEMT 180 LT +H+ +Q+ +G++++ S IHRDL N+ ++E +KI DFGLAR D Sbjct: 197 LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDY 256 Query: 181 GYVATRW----YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLI 235 + APE + + + Y D+WS G ++ E+ + G + +PG ++ Sbjct: 257 VRKGDARLPLKWMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRR 315 Query: 236 LRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLE---KMLVLD 292 LK+ + A +Y ++ + P +L+E +L + Sbjct: 316 -----------LKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQAN 364 Query: 293 SDK 295 + + Sbjct: 365 AQQ 367 Score = 86.1 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 32/119 (26%), Positives = 50/119 (42%), Gaps = 12/119 (10%) Query: 10 RQELNKTIWEVP-ERYQNLSPVGSGAYGSVCAA----FDT-KTGLRVAVKKLSRPFQSII 63 R + + WE P +R + P+G GA+G V A D T VAVK L Sbjct: 16 RLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE 75 Query: 64 HAKRTYRELRLLKHMKHE-NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 H EL++L H+ H NV+ LL T + +V +L+ ++ ++ Sbjct: 76 HR-ALMSELKILIHIGHHLNVVNLLGACTKPG----GPLMVIVEFCKFGNLSTYLRSKR 129 >3HNG-A nrPDB Length = 360 Score = 128 bits (322), Expect = 4e-30, Method: Composition-based stats. Identities = 42/176 (23%), Positives = 79/176 (44%), Gaps = 18/176 (10%) Query: 119 CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT--D 176 + +T + + +Q+ RG++++ S IHRDL N+ ++E+ +KI DFGLAR + Sbjct: 193 KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKN 252 Query: 177 DEMTGYVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQL 232 + TR + APE + + + Y+ D+WS G ++ E+ + G + +PG + Sbjct: 253 PDYVRKGDTRLPLKWMAPESIFDKI-YSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDF 311 Query: 233 KLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKM 288 LR + A Y ++ + P +L+EK+ Sbjct: 312 CSRLR-----------EGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL 356 Score = 85.0 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 32/124 (25%), Positives = 52/124 (41%), Gaps = 12/124 (9%) Query: 5 RPTFYRQELNKTIWEVP-ERYQNLSPVGSGAYGSVCAA-----FDTKTGLRVAVKKLSRP 58 R + + WE ER + +G GA+G V A + T VAVK L + Sbjct: 9 DEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKML-KE 67 Query: 59 FQSIIHAKRTYRELRLLKHMKHE-NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV 117 + K EL++L H+ H NV+ LL T + +V + +L+N + Sbjct: 68 GATASEYKALMTELKILTHIGHHLNVVNLLGACTKQG----GPLMVIVEYCKYGNLSNYL 123 Query: 118 KCQK 121 K ++ Sbjct: 124 KSKR 127 >5X18-A nrPDB Length = 295 Score = 128 bits (321), Expect = 5e-30, Method: Composition-based stats. Identities = 46/268 (17%), Positives = 102/268 (38%), Gaps = 29/268 (10%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH-E 81 Y+ +G G++G + + G+ VA+K A + E + K + Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIKF----EPRKTEAPQLRDEYKTYKILNGTP 63 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC--QKLTDDHVQFLIYQILRGLK 139 N+ F +E LV L+G L ++ +K + V + Q++ ++ Sbjct: 64 NI-PYAYYFG-----QEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIE 117 Query: 140 YIHSADIIHRDLKPSNLAVNEDCE-----LKILDFGLARHTDDEMTGYV----------A 184 +H+ D+I+RD+KP N + + + ++DFG+A+ D T Sbjct: 118 DLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSG 177 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGA 244 T Y + L ++ D+ ++G + L G + G + + ++ + Sbjct: 178 TARYMSINTHLGREQ-SRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKRS 236 Query: 245 ELLKKISSESARNYIQSLTQMPKMNFAN 272 + ++ + + L + ++F Sbjct: 237 TNVYDLAQGLPVQFGRYLEIVRSLSFEE 264 >4JRN-A nrPDB Length = 372 Score = 127 bits (319), Expect = 9e-30, Method: Composition-based stats. Identities = 56/330 (16%), Positives = 104/330 (31%), Gaps = 82/330 (24%) Query: 19 EVPERYQNLS-----------PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHA-K 66 +VP+R+ +++ P+GSG + +V A D +T +AVK + Sbjct: 54 DVPKRFVSVTTGETRTLVRGAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETML 113 Query: 67 RTYRELRLLKHMKH----------------ENVIGLLDV-----FTPARSLEEFNDVYLV 105 RE ++ +V+ L + + +L+ Sbjct: 114 DLQRESSCYRNFSLAKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLL 173 Query: 106 THLMGADLNNIV---------KCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNL 156 AD++ ++ + +L Q ++ + + + I+H D+KP+N Sbjct: 174 MMRAEADMSKVISWVFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANF 233 Query: 157 AVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPE--IMLNWMHYNQTVDIWSVGCIMA 214 + +D L + DFG R ++ + + T Y PE + Y D W +G + Sbjct: 234 LLLKDGRLFLGDFGTYR-INNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLY 292 Query: 215 ELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVF 274 + P D L Sbjct: 293 CIWCKERPTPADGIWDYLH-------------------------------------FADC 315 Query: 275 IGANPLAVDLLEKMLVLDSDKRITAAQALA 304 L DL+ +L D KR+ QAL Sbjct: 316 PSTPELVQDLIRSLLNRDPQKRMLPLQALE 345 >4RT7-A nrPDB Length = 415 Score = 126 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 44/179 (24%), Positives = 74/179 (41%), Gaps = 27/179 (15%) Query: 70 RELRLLKHMKHEN---VIGLLD-VFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDD 125 RE+++ H + + GL F +E N L DL LT + Sbjct: 198 REVQI-----HPDSDQISGLHGNSFHSEDEIEYENQKRLEEE---EDL------NVLTFE 243 Query: 126 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV-- 183 + YQ+ +G++++ +HRDL N+ V +KI DFGLAR + V Sbjct: 244 DLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRG 303 Query: 184 ----ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILR 237 +W APE + + Y D+WS G ++ E+ + G +PG +++ Sbjct: 304 NARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQ 360 Score = 88.8 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 35/130 (26%), Positives = 59/130 (45%), Gaps = 16/130 (12%) Query: 2 SQERPTFY--RQELNKTI-WEVP-ERYQNLSPVGSGAYGSVCAAFD---TKTG--LRVAV 52 S + FY +E + WE P E + +GSGA+G V A +KTG ++VAV Sbjct: 41 SSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAV 100 Query: 53 KKLSRPFQSIIHAKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA 111 K L S + EL+++ + HEN++ LL T + + + + Sbjct: 101 KMLKEKADSS-EREALMSELKMMTQLGSHENIVNLLGACTLSGPI-----YLIFEYCCYG 154 Query: 112 DLNNIVKCQK 121 DL N ++ ++ Sbjct: 155 DLLNYLRSKR 164 >4MWI-A nrPDB Length = 294 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 44/268 (16%), Positives = 96/268 (35%), Gaps = 43/268 (16%) Query: 50 VAVKKLSRPFQSII--HAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTH 107 VA+K + I + +E++ +K + N++ + + ++ ++ + Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICI-DETVTPPQFSIVMEY 108 Query: 108 LMGADLNNIVKCQK-LTDDHVQFLIYQILRGLKYIHSADI--IHRDLKPSNLAVNEDCEL 164 L ++ +K LT L+ RGL +H ++ +H ++ SN V + ++ Sbjct: 109 CELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQV 168 Query: 165 KILDFGLARHTDD-------EMTGYVATRWYRAP-EIMLNWMHYNQTVDIWSVGCIMAEL 216 K+ F L + E T V + Y +P E+ + Y+ +I+S G ++ E+ Sbjct: 169 KLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEI 228 Query: 217 LTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIG 276 TG F G + KL+ K + Sbjct: 229 ATGDIPFQGCNSEKIRKLVA-----------------------------VKRQQEPLGED 259 Query: 277 ANPLAVDLLEKMLVLDSDKRITAAQALA 304 +++++ D R + + L Sbjct: 260 CPSELREIIDECRAHDPSVRPSVDEILK 287 >4L68-A nrPDB Length = 340 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 60/271 (22%), Positives = 111/271 (40%), Gaps = 35/271 (12%) Query: 36 GSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR-ELRLLKHMKHENVIGLLDVFTPAR 94 G+ A G +AVK LS + +R +R E+ L ++H N+ LL Sbjct: 54 GTTYKAL-LPDGSALAVKHLS----TCKLGEREFRYEMNQLWELRHSNLAPLLGFCVV-- 106 Query: 95 SLEEFNDVYLVTHLMGADLNNIVKCQK--LTDDHVQFLIYQILRGLKYIHS---ADIIHR 149 E + ++ L++++ + L + RGL ++H I+H+ Sbjct: 107 ---EEEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQ 163 Query: 150 DLKPSNLAVNEDCELKILDFGLARHT-------DDEMTGYVATRWYRAPEIMLNWMHYNQ 202 ++ S + ++ED + +I+D GLAR MTG + Y APE M + Sbjct: 164 NICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEY-STTMLASL 222 Query: 203 TVDIWSVGCIMAELLTGRTL-----FPGT--DHIDQLKLILRLVGTPGAELLKKISSESA 255 D++ +G ++ EL TG F G+ D + QL+ R+ T + K E Sbjct: 223 KGDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDEEI 282 Query: 256 RNYIQ----SLTQMPKMNFANVFIGANPLAV 282 +++ ++ PK ++ + A+ Sbjct: 283 SKFVEIALNCVSSRPKERWSMFQAYQSLKAI 313 >2PZI-A nrPDB Length = 681 Score = 121 bits (304), Expect = 4e-28, Method: Composition-based stats. Identities = 57/282 (20%), Positives = 101/282 (35%), Gaps = 44/282 (15%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTK-TGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 +Y+ + G G + A D G V +K L + A + L + H Sbjct: 81 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAE-RQFLAEVVHP 139 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 +++ + + + Y+V +G K QKL + +IL L Y+ Sbjct: 140 SIVQIFNFVEHTDRHGDPVG-YIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYL 198 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYN 201 HS +++ DLKP N+ + E+ +LK++D G + Y T ++APEI+ Sbjct: 199 HSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY-GTPGFQAPEIVRTGP--T 254 Query: 202 QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQS 261 DI++VG +A L L L Y+ Sbjct: 255 VATDIYTVGRTLAAL--------------TLDL-----------------PTRNGRYVDG 283 Query: 262 LTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQAL 303 L + + + LL + + D +R T A+ + Sbjct: 284 LPE------DDPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEM 319 >4Y12-A nrPDB Length = 375 Score = 121 bits (304), Expect = 5e-28, Method: Composition-based stats. Identities = 57/282 (20%), Positives = 101/282 (35%), Gaps = 44/282 (15%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTK-TGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 +Y+ + G G + A D G V +K L + A + L + H Sbjct: 120 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAE-RQFLAEVVHP 178 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYI 141 +++ + + + Y+V +G K QKL + +IL L Y+ Sbjct: 179 SIVQIFNFVEHTDRHGDPVG-YIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYL 237 Query: 142 HSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYN 201 HS +++ DLKP N+ + E+ +LK++D G + Y T ++APEI+ Sbjct: 238 HSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY-GTPGFQAPEIVRTGP--T 293 Query: 202 QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQS 261 DI++VG +A L L L Y+ Sbjct: 294 VATDIYTVGRTLAAL--------------TLDL-----------------PTRNGRYVDG 322 Query: 262 LTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQAL 303 L + + + LL + + D +R T A+ + Sbjct: 323 LPE------DDPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEM 358 >1CSN-A nrPDB Length = 298 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 47/286 (16%), Positives = 99/286 (34%), Gaps = 29/286 (10%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82 Y+ +G G++G + + +VA+K + YR +LL Sbjct: 11 HYKVGRRIGEGSFGVIFEGTNLLNNQQVAIK-FEPRRSDAPQLRDEYRTYKLLAGCT--- 66 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIYQILRGLKY 140 + +E LV L+G L +++ +K + V Q+L ++ Sbjct: 67 -----GIPNVYYFGQEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQS 121 Query: 141 IHSADIIHRDLKPSNLAVNEDCE-----LKILDFGLARHTDDEMTGYV----------AT 185 IH +++RD+KP N + + ++DFG+ + D +T T Sbjct: 122 IHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGT 181 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 Y + L ++ D+ ++G + L G + G + R+ + Sbjct: 182 ARYMSINTHLGREQ-SRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKKQST 240 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVL 291 L+++ + + + + + F L K+L Sbjct: 241 PLRELCAGFPEEFYKYMHYARNLAFDATPD--YDYLQGLFSKVLER 284 >5X1R-A nrPDB Length = 302 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 57/274 (20%), Positives = 101/274 (36%), Gaps = 42/274 (15%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVK---------------------KLSRPFQS 61 ++ +G G +G V A+D + +A+K + + FQ+ Sbjct: 22 EFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQA 81 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVT-HLMGADLNNIVKCQ 120 +++ +E RLL H GLL V R EE Y+ T G L N+ Q Sbjct: 82 GLNS--FIQEARLLARFSHP---GLLHVL---RFWEENGTAYMGTQFYSGTTLKNLQAQQ 133 Query: 121 --KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE 178 K+ + ++ L+ + + IH +HRD+ N+ + E +LDFG AR Sbjct: 134 PEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGN 193 Query: 179 M---TGYVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLK 233 + T V + E + DI+++G ++ L+ G + ++ Sbjct: 194 LSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP-----PVSVVR 248 Query: 234 LILRLVGTPGAELLKKISSESARNYIQSLTQMPK 267 I S E R ++L P+ Sbjct: 249 SIEDSYQPLTERRPAGYSPELLRTVDRALALKPE 282 >5USZ-A nrPDB Length = 289 Score = 108 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 41/289 (14%), Positives = 99/289 (34%), Gaps = 38/289 (13%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTG-------LRVAVKKLSRPFQSIIHAKRTYRELRL 74 E +G G + + + G V +K L + ++ +++ + + Sbjct: 8 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRN--YSESFFEAASM 65 Query: 75 LKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK--LTDDHVQFLIY 132 + + H++++ V ++ + + L+ +K K + + Sbjct: 66 MSKLSHKHLVLNYGVCVCGD-----ENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAK 120 Query: 133 QILRGLKYIHSADIIHRDLKPSNLAVNEDCE--------LKILDFGLARHT--DDEMTGY 182 Q+ + ++ +IH ++ N+ + + + +K+ D G++ D + Sbjct: 121 QLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER 180 Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 242 + + PE + N + N D WS G + E+ +G G + L +L Sbjct: 181 IP---WVPPECIENPKNLNLATDKWSFGTTLWEICSG-----GDKPLSALDSQRKLQFYE 232 Query: 243 GAELLKKISSESARNYIQSLTQMPK---MNFANVFIGANPLAV-DLLEK 287 L + N I + +F + N L DL+ + Sbjct: 233 DRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPDLVPR 281 >4L00-A nrPDB Length = 304 Score = 108 bits (269), Expect = 5e-24, Method: Composition-based stats. Identities = 50/302 (16%), Positives = 95/302 (31%), Gaps = 68/302 (22%) Query: 20 VPERYQNLSPVGSGAYGSVCAAF------DTKTGLRVAVKKLSRPFQ-SIIHAKRTYREL 72 + + +G G + + D T +K + + S + E Sbjct: 23 LKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEA 82 Query: 73 -RLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA---DLNNIVKCQKLTDDHVQ 128 +++ + H++++ L V + +V + DL K LT Sbjct: 83 ASMMRQVSHKHIVYLYGVCVRD------VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKF 136 Query: 129 FLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE-------LKILDFG-----LARHTD 176 + Q+ L Y+ D++H ++ NL + + +K+ D G L+R Sbjct: 137 KVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQEC 196 Query: 177 DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAEL-LTGRTLFPGTDHIDQLKLI 235 E + APE + + + + D WS G + E+ G Sbjct: 197 IER------IPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIP------------- 237 Query: 236 LRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDK 295 L K E R Y + V LA DL+ + + D ++ Sbjct: 238 ----------LKDKTLIEKERFY--------ESRCRPVTPSCKELA-DLMTRCMNYDPNQ 278 Query: 296 RI 297 R Sbjct: 279 RP 280 >5UV4-A nrPDB Length = 311 Score = 107 bits (267), Expect = 8e-24, Method: Composition-based stats. Identities = 44/207 (21%), Positives = 78/207 (37%), Gaps = 19/207 (9%) Query: 28 SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLL 87 +G +G+ A G + VK L F K RE++ L ++H N++ L Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSK--KEFSREIKKLGSVRHPNLVPLR 87 Query: 88 DVFTPARSLEEFNDVYLVTHLMGADLNNIVKC------QKLTDDHVQFLIYQILRGLKYI 141 + + E + + + L+ + L+ + I R L Y+ Sbjct: 88 GYYWGPK---EHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYL 144 Query: 142 HSADII-HRDLKPSNLAV-NEDCELKILDFGLARHTDD----EMTGYVATRWYRAPEIML 195 H+ +I H ++K SN+ + N + D+ L R E Y PE Sbjct: 145 HNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSS 204 Query: 196 NWMHY-NQTVDIWSVGCIMAELLTGRT 221 + D+++ G I+ ELLTG+ Sbjct: 205 TSKPCPSLKSDVYAFGVILLELLTGKI 231 >3REP-A nrPDB Length = 271 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 50/286 (17%), Positives = 97/286 (33%), Gaps = 49/286 (17%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81 ++ L+ + G + G + VK L S ++ E L+ H Sbjct: 10 KQLNFLTKLNENHSGELWKGRWQ--GNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHP 67 Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK---LTDDHVQFLIYQILRG 137 NV+ +L + L+TH M L N++ + + RG Sbjct: 68 NVLPVLGACQSPPAPHPT----LITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARG 123 Query: 138 LKYIHSA-DIIHR-DLKPSNLAVNEDCELKI--LDFGLARHTDDEMTGYVATRWYRAPEI 193 + ++H+ +I R L ++ ++ED +I D + + M + APE Sbjct: 124 MAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQSPGRMYA----PAWVAPEA 179 Query: 194 MLNWMHYN--QTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 + ++ D+WS ++ EL+T F ++ E+ K++ Sbjct: 180 LQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNM---------------EIGMKVA 224 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI 297 E R + G +P L++ + D KR Sbjct: 225 LEGLR--------------PTIPPGISPHVSKLMKICMNEDPAKRP 256 >5M07-A nrPDB Length = 276 Score = 104 bits (261), Expect = 5e-23, Method: Composition-based stats. Identities = 38/208 (18%), Positives = 73/208 (35%), Gaps = 27/208 (12%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH-AKRTYRELRLLKHMKHEN 82 Y + +G+ A G V A+K LS + +R RE + + H + Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQ---KLTDDHVQFLIYQILRGL 138 ++ + D E +++ + D + + L V ++ + L Sbjct: 92 ILEVHD------RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGAL 145 Query: 139 KYIHSADIIHRDLKPSNLAVNE----DCELKILDFGLARHTDDEMTGYVATRWYRAPEIM 194 Y H ++HRD+ P+N+ + D + + DFG+A Y APE+ Sbjct: 146 DYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-----------PSYPAPELS 194 Query: 195 LNWMHYNQTVDIWSVGCIMAELLTGRTL 222 + D +++ L G Sbjct: 195 AG-ADVDGRADQYALALTAIHLFAGAPP 221 >5OAT-A nrPDB Length = 411 Score = 103 bits (258), Expect = 9e-23, Method: Composition-based stats. Identities = 59/339 (17%), Positives = 100/339 (29%), Gaps = 92/339 (27%) Query: 23 RYQNLSPVGSGAYGSVCAAFDTKT-----GLRVAVKKL---SRPFQSIIHAKRTYRE--- 71 P+ G G V +A A+K + S+ K YRE Sbjct: 12 DLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETVP 71 Query: 72 LRLL-----------------KHMK-HENVIGLLDVFTPARSL-----------EEFNDV 102 R+ KH+ H N++ + VFT + Sbjct: 72 ARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSL 131 Query: 103 YLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN--- 159 +L+ +L + + + L+ Q+L G+ ++ + I HRDLK NL ++ Sbjct: 132 FLLMKRYDCNLQSFLSTAP-STRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSE 190 Query: 160 -EDCELKILDF---------GLARHTDDEMTGYVATRWYRAPEIMLNWMH------YNQT 203 E L I DF GL+ APEI+ Y+ Sbjct: 191 PESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYS-K 249 Query: 204 VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLT 263 D+W+VG I E+ F G + Sbjct: 250 ADLWAVGAIAYEIFNCHNPFYGPSRLKNFN------------------------------ 279 Query: 264 QMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQA 302 + + + + L+ +L + +KR+ A Sbjct: 280 -YKEGDLPKLPDEVPTVIQALVANLLKRNPNKRLDPEVA 317 >5CLR-A nrPDB Length = 451 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 38/193 (19%), Positives = 74/193 (38%), Gaps = 21/193 (10%) Query: 39 CAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEE 98 + G +K + +S+ E L + L+ F ++ Sbjct: 96 FKVYALDDGKTYFLKSVKIDAESLTE---FTNEKDTLSKLG-----RLVGTFFNEQT--- 144 Query: 99 FNDVYLVTHLMGADLNNIVKCQKLTDD-----HVQFLIYQILRGLKYIHSADIIHRDLKP 153 L T + G DL+ L + V ++ + +K H +IHRDLKP Sbjct: 145 QVHYILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKP 204 Query: 154 SNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEI--MLNWMHYNQTVDIWSVGC 211 N+ ++ D + ++DFG + + T Y APE+ +++ ++Q D++++ Sbjct: 205 GNIMLDADMQCHLVDFGSSSSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAY 264 Query: 212 IMAELLTGRTLFP 224 + EL F Sbjct: 265 SLDELFN---PFR 274 >6EQI-C nrPDB Length = 433 Score = 101 bits (252), Expect = 4e-22, Method: Composition-based stats. Identities = 59/312 (18%), Positives = 100/312 (32%), Gaps = 78/312 (25%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDT-----KTGLRVAVKKL---SRPFQSIIHAKRTYRE-- 71 + P+ G V +A K ++AVK + S K YRE Sbjct: 15 DELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETV 74 Query: 72 -------------LRLLKHMK-----HENVIGLLDVFTPARSLEEFND------------ 101 + + K H N++ + VF + N Sbjct: 75 PAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRIN 134 Query: 102 ---------VYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLK 152 ++LV L ++ + L+ Q+L + +++ +I HRDLK Sbjct: 135 PEGSGRNMSLFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQLLEAVAHMNIHNISHRDLK 194 Query: 153 PSNLAVNED-----CELKILDFGLARHTDDEMTGYV-----------ATRWYRAPEIM-- 194 N+ V+ + I DFG D+ G V R APEI Sbjct: 195 SDNILVDLSEGDAYPTIVITDFGCC--LCDKQNGLVIPYRSEDQDKGGNRALMAPEIANA 252 Query: 195 ----LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250 +W++Y + D+W+VG I E+ F +KL+ + L Sbjct: 253 KPGTFSWLNY-KKSDLWAVGAIAYEIFNIDNPFYD----KTMKLLSKSYKEEDLPELPDT 307 Query: 251 SSESARNYIQSL 262 RN + ++ Sbjct: 308 IPFIIRNLVSNM 319 >5C01-A nrPDB Length = 342 Score = 101 bits (251), Expect = 7e-22, Method: Composition-based stats. Identities = 39/277 (14%), Positives = 91/277 (32%), Gaps = 53/277 (19%) Query: 41 AFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFN 100 D LRV +K L I A Y L+ + H ++ + V Sbjct: 101 GRDRGQELRVVLKVLDPSHHDIALA--FYETASLMSQVSHTHLAFVHGVCVRGP-----E 153 Query: 101 DVYLVTHLMGADLNNIVKCQK--LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV 158 ++ + ++ L+ ++ ++ + + Q+ L Y+ + +++H ++ N+ + Sbjct: 154 NIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILL 213 Query: 159 NEDCE-------LKILD--FGLARHTDDEMTGYVATRWYRAPEIMLNWMHY-NQTVDIWS 208 +K+ D GL + +E + + APE + + + +D W Sbjct: 214 ARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLSTAMDKWG 270 Query: 209 VGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKM 268 G + E+ G L+ S ++ Q ++P+ Sbjct: 271 FGATLLEI-----------------------CFDGEAPLQSRSPSEKEHFYQRQHRLPEP 307 Query: 269 NFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAH 305 + + L + L + +R + L Sbjct: 308 SCPQLAT--------LTSQCLTYEPTQRPSFRTILRD 336 >4WOV-A nrPDB Length = 317 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 39/277 (14%), Positives = 91/277 (32%), Gaps = 53/277 (19%) Query: 41 AFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFN 100 D LRV +K L I A Y L+ + H ++ + V Sbjct: 78 GRDRGQELRVVLKVLDPSHHDIALA--FYETASLMSQVSHTHLAFVHGVCVRGP-----E 130 Query: 101 DVYLVTHLMGADLNNIVKCQK--LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV 158 ++ + ++ L+ ++ ++ + + Q+ L Y+ + +++H ++ N+ + Sbjct: 131 NIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILL 190 Query: 159 NEDCE-------LKILD--FGLARHTDDEMTGYVATRWYRAPEIMLNWMHY-NQTVDIWS 208 +K+ D GL + +E + + APE + + + +D W Sbjct: 191 ARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLSTAMDKWG 247 Query: 209 VGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKM 268 G + E+ G L+ S ++ Q ++P+ Sbjct: 248 FGATLLEI-----------------------CFDGEAPLQSRSPSEKEHFYQRQHRLPEP 284 Query: 269 NFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAH 305 + + L + L + +R + L Sbjct: 285 SCPQLAT--------LTSQCLTYEPTQRPSFRTILRD 313 >4I94-A nrPDB Length = 300 Score = 93.8 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 42/271 (15%), Positives = 95/271 (35%), Gaps = 45/271 (16%) Query: 37 SVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSL 96 V + R+AVK+ +R +S +++ E + + +++ + LL Sbjct: 44 VVYKGK-LENQRRIAVKRFNR--KSWPDSRQFLEEAKAVGQLRNHRMANLLGCC-----Y 95 Query: 97 EEFNDVYLVTHLMGADLNNIV---KCQKLTDDHVQFLIYQILRGLKYIHSAD-IIHRDLK 152 E+ + + + L + + Q + + I + L+Y S ++ DL Sbjct: 96 EDEERLLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLN 155 Query: 153 PSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCI 212 + ++D ++ FGL +++ D Y + PE + ++V I+S G + Sbjct: 156 AYRVLFDDDANPRLSCFGLMKNSRDG-KSYSTNLAFTPPEYLRTGRVTPESV-IYSFGTL 213 Query: 213 MAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFAN 272 + +LL+G K I A + I+ M+ Sbjct: 214 LLDLLSG----------------------------KHIPPSHALDLIRDRNIQMLMDSGL 245 Query: 273 VFIGANPLAVDLL---EKMLVLDSDKRITAA 300 ++ +L+ + L + +R Sbjct: 246 EGQFSSDDGTELIRLASRCLQYEPRERPNPK 276 >4IX6-A nrPDB Length = 350 Score = 91.9 bits (227), Expect = 4e-19, Method: Composition-based stats. Identities = 60/341 (17%), Positives = 114/341 (33%), Gaps = 73/341 (21%) Query: 21 PERYQNL-SPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR-ELRLLKHM 78 P+ + L P+GSG +G+V V L ++ A+ E+ + H+ Sbjct: 18 PKDIRVLPGPLGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAEELLECEMDVNYHV 73 Query: 79 KHEN----VIGLLDVFTPA-------RSLEEFNDVYLVTHLMGA-DLNNIVKCQKLTDDH 126 H N + + ++L+ G + +++ Sbjct: 74 -HANAKGTCARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLAT 132 Query: 127 V------------QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE--DCELKILDFG-- 170 + + ++L L +H ++HRD+KP+NL E LK++D G Sbjct: 133 AMACADATELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAA 192 Query: 171 -LARHTDDEMTGYVA-----TRWYRAPEIMLNWMHYNQTV----------------DIWS 208 L + + Y R+ +A E+ L + D WS Sbjct: 193 ALCLPLPETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWS 252 Query: 209 VGCIMAELL-TGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPK 267 GC+M +L G +++ + VG + S E +L Sbjct: 253 AGCVMLQLAVVGL---RTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALDANGG 309 Query: 268 MNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308 + DL ++++ + D R + AL+HA+F Sbjct: 310 AGW------------DLCQRLMEAERDARASCEAALSHAFF 338 >4CI6-B nrPDB Length = 643 Score = 88.8 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 51/280 (18%), Positives = 108/280 (38%), Gaps = 39/280 (13%) Query: 54 KLSRPFQSIIHAKRTYRELRLLKHM-----KHENVIGLLDVFTPARSLEEFNDVYLVTHL 108 +L + I + EL KH+ KH N+ + + L+ + Sbjct: 70 RLVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHG-MAVVPYGNRYYYALLMDEV 128 Query: 109 MG-------ADLNNIVKCQKLT----DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLA 157 G L + K K+ ++F+ +++L ++ A I+H D+KP N+ Sbjct: 129 DGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIKPGNVV 188 Query: 158 VNE-DCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAEL 216 + E ++D GL + ++ G+ T ++APE+ + + ++ D++ +++ L Sbjct: 189 FDRASGEPVVIDLGLHSRSGEQPKGF--TESFKAPELGVGNLGASEKSDVF---LVVSTL 243 Query: 217 LTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIG 276 L G F I + L+ I+SE A ++ + + A V Sbjct: 244 LHGIEGFEKDPEIK------------PNQGLRFITSEPAHVMDENGYPIHRPGIAGVETA 291 Query: 277 ANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDD 316 D +L + +D R + +A H + + ++ Sbjct: 292 YTRFITD----ILGVSADSRPDSNEARLHEFLSDGTIDEE 327 >6J6I-B nrPDB Length = 351 Score = 87.3 bits (215), Expect = 9e-18, Method: Composition-based stats. Identities = 37/187 (19%), Positives = 72/187 (38%), Gaps = 23/187 (12%) Query: 52 VKKLSRPFQSIIHA--KRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHL 108 +K+ S + K Y ++ L M H N + LL LE V + Sbjct: 86 IKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCC-----LEFPFPVLVFEFA 140 Query: 109 MGADLNN----IVKCQK--LTDDHVQFLIYQILRGLKYIHS---ADIIHRDLKPSNLAVN 159 +N IV ++ L + +I + Y+H+ IIHRD+KP ++ ++ Sbjct: 141 EHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLD 200 Query: 160 EDCELKILDFGLARHTDDEMTG-----YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMA 214 ++ K+ D + + + + T Y P + + D++S G + Sbjct: 201 KNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYSFGICLL 259 Query: 215 ELLTGRT 221 ++TG+ Sbjct: 260 VIITGKP 266 >5UU1-A nrPDB Length = 324 Score = 86.1 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 43/225 (19%), Positives = 88/225 (39%), Gaps = 30/225 (13%) Query: 26 NLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIG 85 +GSG +G + AF T + A + +Q + EL+ + + ++ I Sbjct: 20 LGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGP---LFSELKFYQRVAKKDCIK 76 Query: 86 ---------LLDV--FTPARSLEEFNDVY--LVTHLMGADLNNIV-KCQKLTDDHVQFLI 131 L + F + E Y +V +G DL I + V L Sbjct: 77 KWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLG 136 Query: 132 YQILRGLKYIHSADIIHRDLKPSNLAVN--EDCELKILDFGLA----------RHTDDEM 179 ++L L+YIH + +H D+K +NL + ++ + D+GL+ ++ ++ Sbjct: 137 IRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPR 196 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFP 224 G+ T + + + + ++ D+ +G M L G+ + Sbjct: 197 KGHNGTIEFTSLDAHKG-VALSRRSDVEILGYCMLRWLCGKLPWE 240 >2RSV-A nrPDB Length = 403 Score = 78.8 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 44/235 (18%), Positives = 94/235 (40%), Gaps = 35/235 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRV------AVKKLS----------RPFQSIIHA 65 + ++ P+G G +G + A D + V VK + +Q Sbjct: 42 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 100 Query: 66 KRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ--KLT 123 ++ + +R + +K+ V ++ + + +++ G+DL I + + + Sbjct: 101 EQIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYR--FMIMDRFGSDLQKIYEANAKRFS 157 Query: 124 DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN--EDCELKILDFGLA--------- 172 V L +IL L+YIH + +H D+K SNL +N ++ ++D+GLA Sbjct: 158 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 217 Query: 173 -RHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGT 226 + +D + T + + + ++ D+ +G M + LTG + Sbjct: 218 KEYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDN 271 >2LAV-A nrPDB Length = 361 Score = 78.0 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 44/235 (18%), Positives = 94/235 (40%), Gaps = 35/235 (14%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRV------AVKKLS----------RPFQSIIHA 65 + ++ P+G G +G + A D + V VK + +Q Sbjct: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 Query: 66 KRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ--KLT 123 ++ + +R + +K+ V ++ + + +++ G+DL I + + + Sbjct: 94 EQIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYR--FMIMDRFGSDLQKIYEANAKRFS 150 Query: 124 DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN--EDCELKILDFGLA--------- 172 V L +IL L+YIH + +H D+K SNL +N ++ ++D+GLA Sbjct: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 210 Query: 173 -RHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGT 226 + +D + T + + + ++ D+ +G M + LTG + Sbjct: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDN 264 >6G4J-A nrPDB Length = 315 Score = 68.4 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 51/261 (19%), Positives = 89/261 (34%), Gaps = 43/261 (16%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 Y +G GA G V A + VA+K + E+ +LK Sbjct: 28 YTLRKQLGKGANGIVYLAE--TSDGHVALKV-------SDDSLSITSEVNVLKSFSKA-- 76 Query: 84 IGLLDVFTPARSLEEFNDVYL-----------VTHLMGADLNNIVKCQKLTDDHVQFLIY 132 T S + +D Y+ + ++ G L V + + + L+ Sbjct: 77 ----QSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKG--AEWIPVLMI 130 Query: 133 QILRGLKYIHSADIIHRDLKPSN-LAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAP 191 Q+L L +H I DLKP N + ++ +D G + Y T +Y Sbjct: 131 QLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEY--TEFY--- 185 Query: 192 EIMLNWMHYNQ-----TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 + Y + D+++V IM + + +QL+ ++ G P + Sbjct: 186 --DRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSLIE--GNPLLQK 241 Query: 247 LKKISSESARNYIQSLTQMPK 267 KK + QS +M K Sbjct: 242 YKKALFSALNGDYQSADEMKK 262 >4OAU-C nrPDB Length = 699 Score = 68.0 bits (165), Expect = 5e-12, Method: Composition-based stats. Identities = 48/314 (15%), Positives = 98/314 (31%), Gaps = 83/314 (26%) Query: 6 PTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHA 65 YR + K + + E+Y+ + G + F K VAVK Sbjct: 331 HRIYRPMIGKLKFFIDEKYKIADT----SEGGIYLGFYEK--QEVAVKTFCEGSP----- 379 Query: 66 KRTYRELRLLKHMK-HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTD 124 R RE+ L+ + + +++ S +++ L L + + D Sbjct: 380 -RAQREVSCLQSSRENSHLVTFYG------SESHRGHLFVCVTLCEQTLEACLDVHRGED 432 Query: 125 DH------VQFLIYQILRGLKYIH-SADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD 177 + ++ I + ++ +H S H+DL+P N+ ++ + DF D Sbjct: 433 VENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF-------D 485 Query: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 237 + + E+ D+ + + +L L + Sbjct: 486 KSIKWAGDPQ----EV---------KRDL--------------------EDLGRLVLYVV 512 Query: 238 LVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI 297 G+ E LK S+E V + + DL+ ++ R Sbjct: 513 KKGSISFEDLKAQSNEEV-----------------VQLSPDEETKDLIHRLFHPGEHVRD 555 Query: 298 TAAQALAHAYFAQY 311 + L H +F + Sbjct: 556 CLSDLLGHPFFWTW 569 >4O1O-A nrPDB Length = 717 Score = 67.2 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 41/302 (13%), Positives = 93/302 (30%), Gaps = 88/302 (29%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 79 + E Y+ A G + VAVK+ S R +E+ L+ + Sbjct: 348 IDEEYKIADT----AEGGIYLGLYED--QEVAVKRFSEGST------RGQQEVSCLQSSR 395 Query: 80 -HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLT------DDHVQFLIY 132 ++NV+ + L + L L + + D+ + ++ Sbjct: 396 ANDNVVTFYGSESDGSCLH------VCLALCEYTLQEHLANHRGDAVPNEEDESARNILS 449 Query: 133 QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPE 192 + + + +H + H+DL+P N+ ++ + DF + ++ Sbjct: 450 SLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQK----------- 498 Query: 193 IMLNWMHYNQTVDIWSVG-CIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 D+ ++G ++ + G F + ++I G+P E Sbjct: 499 ---------IKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQ---GSPDEET----- 541 Query: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVL--DSDKRITAAQALAHAYFA 309 DL+ + + + R+++ LAH +F Sbjct: 542 ------------------------------RDLIHHLFHPGDNVEDRLSS--LLAHPFFW 569 Query: 310 QY 311 + Sbjct: 570 SW 571 >6M7Z-A nrPDB Length = 319 Score = 64.2 bits (155), Expect = 8e-11, Method: Composition-based stats. Identities = 37/234 (15%), Positives = 85/234 (36%), Gaps = 55/234 (23%) Query: 103 YLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC 162 Y+ L + ++++ + + VQ L ++ LK +H+ ++HR ++ ++ +V D Sbjct: 123 YIFHPLSKGLVGDMLETGR-SHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDG 181 Query: 163 ELKILDFGLARHTDDEMTGYVATRWY---RAPEI--------MLNWMHYNQTVDIWSVGC 211 + + A E +V ++ APEI L + D++S+G Sbjct: 182 TVVLGGLDTAAPIGTETRLWVG--FFGQETAPEIDRNFLADLALTQGRHTVKSDVYSLGV 239 Query: 212 IMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFA 271 + +++L+G L + +++++ L + Sbjct: 240 -------------------AFRNLVQLLG--NGNLGPEDRGAVRQDHLELLDK------- 271 Query: 272 NVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPD-DEPVADPYD 324 L +KM+ + R T + + F + D +E A P+ Sbjct: 272 ------------LSQKMIEEEPGNRPTIEEIMKDPLFEGLNFEDIEEGKARPFR 313 >2JII-A nrPDB Length = 352 Score = 63.4 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 35/213 (16%), Positives = 85/213 (39%), Gaps = 25/213 (11%) Query: 96 LEEFNDVYLVTHLMGADLN---NIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLK 152 + + +LV +G L ++ L++ V + ++L L+++H + +H ++ Sbjct: 127 VHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVT 186 Query: 153 PSNLAVN--EDCELKILDFGLA----------RHTDDEMTGYVATRWYRAPEIMLNWMHY 200 N+ V+ + ++ + +G A + + + + + + ++ Sbjct: 187 AENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP- 245 Query: 201 NQTVDIWSVGCIMAELLTGRTLFPG--TDHIDQLKLILRLVGTPGAELLKKI----SSES 254 ++ D+ S+G M + L G + + D +K + V PG + SE+ Sbjct: 246 SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSET 305 Query: 255 ARNYIQ---SLTQMPKMNFANVFIGANPLAVDL 284 + Y++ +LT K +A + L DL Sbjct: 306 LQKYLKVVMALTYEEKPPYAMLRNNLEALLQDL 338 >5DMZ-A nrPDB Length = 365 Score = 61.9 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 39/213 (18%), Positives = 72/213 (33%), Gaps = 25/213 (11%) Query: 29 PVGSGAYGSVCAAF-----DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 83 +G GA+ V A D K + +K + E RL M+H Sbjct: 72 LLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLME-RLKPSMQHMF- 129 Query: 84 IGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQKLTDDHVQFLIYQILRGLKYIH 142 + ++Y L+ A +L + + V ++L ++ +H Sbjct: 130 MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVH 189 Query: 143 SADIIHRDLKPSNLAVNEDCE-----------LKILDFGLARHT-----DDEMTGYVATR 186 +IIH D+KP N + L ++D G + T T Sbjct: 190 DCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETS 249 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTG 219 ++ E++ N +N +D + V + +L G Sbjct: 250 GFQCVEMLSN-KPWNYQIDYFGVAATVYCMLFG 281 >4CYJ-A nrPDB Length = 438 Score = 59.5 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 28/144 (19%), Positives = 60/144 (41%), Gaps = 20/144 (13%) Query: 38 VCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLE 97 V A +++ G A+++L + + K ++ K +K+ +++ + +VFT Sbjct: 71 VYKAQNSRNGRHYALRRL--EGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFTT----R 124 Query: 98 EFNDVYLVTHLMGADLNNIVKCQKL--------------TDDHVQFLIYQILRGLKYIHS 143 EF D L+ L+ ++ ++ + I QI LK IHS Sbjct: 125 EFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHS 184 Query: 144 ADIIHRDLKPSNLAVNEDCELKIL 167 + R L+PS + + + +++ Sbjct: 185 NRLAARCLEPSKIILTDINRIRLS 208 >3ENH-A nrPDB Length = 540 Score = 58.4 bits (140), Expect = 5e-09, Method: Composition-based stats. Identities = 38/176 (21%), Positives = 72/176 (40%), Gaps = 26/176 (14%) Query: 8 FYRQELNKTIW--EVPERYQNL--SPVGSGAYGSVCAAFDTKTGLRVAVK-KLSRPFQSI 62 YR ++ + W E+ + + + +G GA + D+ V +K ++ + ++ Sbjct: 318 NYRTDMVEVNWIKEIKGKKRKIPEHLIGKGAEADIK--RDSYLDFDVIIKERVKKGYRDE 375 Query: 63 -----IHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV 117 I RT RE R L ++ + P + ++ ++ + L V Sbjct: 376 RLDENIRKSRTAREARYLA------LVKDFGIPAPYIFDVDLDNKRIMMSYINGKLAKDV 429 Query: 118 KCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR 173 L + Y+I + +H D+IH DL SN ++D L I+DFGL + Sbjct: 430 IEDNLD------IAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGK 477 >6EWX-A nrPDB Length = 484 Score = 58.0 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 41/239 (17%), Positives = 73/239 (30%), Gaps = 74/239 (30%) Query: 107 HLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC---- 162 + + + ++ + V FL+ Q+ GL+++ IIHRDL NL + Sbjct: 192 DFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSS 251 Query: 163 -------------------------------------ELKILDFGLARHTDDEMTGY--V 183 L I +F A+ T Sbjct: 252 PGPSANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQK 311 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPG 243 ++ APEI+ + + D + G ++ ELL F Sbjct: 312 KSQARLAPEIVSASQY--RKFDEFQTGILIYELLHQPNPF-------------------- 349 Query: 244 AELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQA 302 E+ ++ R + L +P ++ +P L +L D KRI +A Sbjct: 350 -EVRAQLRERDYRR--EDLPPLPTLSLY------SPGLQQLAHLLLEADPIKRIRIGEA 399 >6EAS-A nrPDB Length = 308 Score = 55.7 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 42/281 (14%), Positives = 85/281 (30%), Gaps = 58/281 (20%) Query: 39 CAAFDTKTGLRVAV--------KKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVF 90 +G+ +AV K S+ +S K + L + H+N + LL Sbjct: 57 YKGT-LSSGVEIAVASSLVTSAKDWSKENESQYRKK-----ITNLSKVSHKNFMNLLGYC 110 Query: 91 TPARSLEEFNDVYLVTHLMGADLNNIVK---CQKLTDDHVQFLIYQILRGLKYIHSADI- 146 F V + + L + +KL + I L+++H Sbjct: 111 EEE---HPFTRVMVFEYAPNGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQTP 167 Query: 147 -IHRDLKPSNLAVNEDCELKILDFGL---ARHTDDEMTGYVATRWYRAPEIMLNWMHYNQ 202 R+ + + + +D K+ D A+ + +A +P++ Y Sbjct: 168 AALRNFDSTTVYLTDDFAAKVSDLEFWNDAKGHNSTTNNELA----FSPDMEDIVRKY-- 221 Query: 203 TVDIWSVGCIMAELLTGRTLFPGTD-HIDQLKLILRLVGTPGAELLKKISSESARNYIQS 261 G ++ E+LTGR D ++ G EL+ + ++ Sbjct: 222 -------GMVLLEILTGRVPSSEDDGPLENWVSRYFEGGMRLEELIDPSIGFFPEDTARA 274 Query: 262 LTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQA 302 L ++ + + D KR + Sbjct: 275 LCEV-------------------VRSCIDRDPKKRPQMKEV 296 >6G38-A nrPDB Length = 357 Score = 55.3 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 32/204 (15%), Positives = 62/204 (30%), Gaps = 54/204 (26%) Query: 4 ERPTFYRQELNKTIWEVP---------ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKK 54 Y Q + + + P E+ Q +G G +G V VA+K Sbjct: 14 GTENLYFQSMGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTI--ADHTPVAIKI 71 Query: 55 L------------SRPFQSIIHAKRTYRELRLLKH-----------MKHENVIG------ 85 + + F+ I+ +EL LL + + + Sbjct: 72 IAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPL 131 Query: 86 LL----------DVFTPARSLEEFNDVYLV--THLMGADLNNIVKCQKLTDDHVQFLIYQ 133 LL + + +++V G DL ++ + + + +++Q Sbjct: 132 LLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQ-MRTKLSSLATAKSILHQ 190 Query: 134 ILRGLKYIH-SADIIHRDLKPSNL 156 + L S HRDL N+ Sbjct: 191 LTASLAVAEASLRFEHRDLHWGNV 214 >4AZV-A nrPDB Length = 569 Score = 53.8 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 21/121 (17%), Positives = 46/121 (38%), Gaps = 16/121 (13%) Query: 55 LSRPFQSIIHAKRTYRELRLLKH----MKHENVIGLLDVFTPARSLEEFNDVYLVTH-LM 109 + +S + + E++ L V+ E +LV L Sbjct: 275 ILTAEESQRNKYELHNEIKFLTQPPAGFDAPAVLA---------HGENAQSGWLVMEKLP 325 Query: 110 GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDF 169 G L++++ + + ++ +LR L + H D++P N+ V+ +++DF Sbjct: 326 GRLLSDMLAAG--EEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVDARQHARLIDF 383 Query: 170 G 170 G Sbjct: 384 G 384 >4AZW-A nrPDB Length = 471 Score = 53.8 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 21/121 (17%), Positives = 46/121 (38%), Gaps = 16/121 (13%) Query: 55 LSRPFQSIIHAKRTYRELRLLKH----MKHENVIGLLDVFTPARSLEEFNDVYLVTH-LM 109 + +S + + E++ L V+ E +LV L Sbjct: 275 ILTAEESQRNKHELHNEIKFLTQPPAGFDAPAVLA---------HGENAQSGWLVMEKLP 325 Query: 110 GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDF 169 G L++++ + + ++ +LR L + H D++P N+ V+ +++DF Sbjct: 326 GRLLSDMLAAG--EEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDF 383 Query: 170 G 170 G Sbjct: 384 G 384 >6BHC-A nrPDB Length = 438 Score = 53.0 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 42/296 (14%), Positives = 86/296 (29%), Gaps = 78/296 (26%) Query: 50 VAVKKLSRPFQSIIH-------AKRTYRELRLLKHMKH-----ENVIGLLDVFTPARS-- 95 AVK + + + + H N LL P++ Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPN--RLLPWEDPSKKQR 143 Query: 96 -----LEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRD 150 + V + L K L + V L+ Q+ GL+++ + H D Sbjct: 144 SHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCD 203 Query: 151 LKPSNLAV---NEDCELKILDFG---------------LARHTDDEMTGYVATRWY---- 188 L+ NL + + FG ++ + + ++ Sbjct: 204 LRLENLLLVHYQPGGTAQ--GFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQ 261 Query: 189 --RAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246 APEI+ + + D + G ++ E+L F Sbjct: 262 SRLAPEIITATQY--KKCDEFQTGILIYEMLHLPNPF----------------------- 296 Query: 247 LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQA 302 + R Y ++ +P++ F + + + L +L + +RI + A Sbjct: 297 -DENPELKEREYTRA--DLPRIPFRSPY---SRGLQQLASCLLNPNPSERILISDA 346 >5VE6-A nrPDB Length = 492 Score = 52.6 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 14/35 (40%), Positives = 21/35 (60%) Query: 124 DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV 158 + V FL+ Q+ GL+++ IIHRDL NL + Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 Score = 34.5 bits (78), Expect = 0.081, Method: Composition-based stats. Identities = 19/114 (16%), Positives = 31/114 (27%), Gaps = 31/114 (27%) Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLK 248 APEI+ + + D + G ++ ELL F Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELLHQPNPF------------------------- 357 Query: 249 KISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQA 302 E + + + +P L +L D KRI +A Sbjct: 358 ----EVRAQLRERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGEA 407 >5GZA-A nrPDB Length = 290 Score = 51.5 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 40/210 (19%), Positives = 71/210 (33%), Gaps = 36/210 (17%) Query: 25 QNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVI 84 + + +G GA V + G +VA+ LS S +A L +L+ ++ +V+ Sbjct: 28 RRVKLIGQGAVKKVYLSEWQ--GQKVALSVLS----SDQYADDFLHGLSMLRALQSSHVV 81 Query: 85 GLLDVFTPARSL-EEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS 143 L+ V E++ + V L + + + L + L Y+HS Sbjct: 82 TLVGVCEEDAVFVTEYHPLGSVLTLDTTLAQERYRWRN-SWHTRLQLAIDYVAFLAYLHS 140 Query: 144 A--DI--------IHRDLKPSNLAVNEDCELKILDF-GLARHTDDEMTGYVA----TRWY 188 + I +H+ L S + D L D L + T + Sbjct: 141 SPAGIRVMCDSNDLHKTL--SQFLLASDMRLLANDLDALPEVEKGGLGVKCGHHELTGDF 198 Query: 189 RAPEIM-----------LNWMHYNQTVDIW 207 APE + Y++ DIW Sbjct: 199 VAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >5GZ9-A nrPDB Length = 305 Score = 50.7 bits (120), Expect = 9e-07, Method: Composition-based stats. Identities = 40/213 (18%), Positives = 77/213 (36%), Gaps = 45/213 (21%) Query: 27 LSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGL 86 L VG GA V + + +VA+ +L+R + + L++LK ++ E+V+ L Sbjct: 39 LKRVGEGAVKRVFLSEWKE--HKVALSRLTR----LEMKEDFLHGLQMLKSLQSEHVVTL 92 Query: 87 LDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL-------TDDHVQFLIYQILRGLK 139 + ++ L + L+N+ + +L T H L + + + Sbjct: 93 VGYCEEDGTI-------LTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIIN 145 Query: 140 YIHSADIIHRDLKPSN--------LAVNEDCELKILDFGLARHTDDEMTG--YVATRW-- 187 Y+H + + R + SN + + + D D + R Sbjct: 146 YLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRELH 205 Query: 188 --YRAPEIMLNWM-----------HYNQTVDIW 207 + APE + + YN+ VDIW Sbjct: 206 GDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >4WWA-A nrPDB Length = 261 Score = 49.5 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 35/174 (20%), Positives = 61/174 (35%), Gaps = 36/174 (20%) Query: 27 LSPVGSGAYGSV-------CAAFDTKTGLRVAVKKLSRPFQSIIHAK--------RTYRE 71 ++P+ GA V + + +K RP + H + RT E Sbjct: 19 IAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIK--YRPPKRYRHPQIDQALTKHRTLNE 76 Query: 72 LRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-----------NNIVKCQ 120 RLL + +I + P + + ++ +G DL + Q Sbjct: 77 SRLLAKL---YLIP--GLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQ 131 Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC---ELKILDFGL 171 D V + ++ R + +H D H DL SN+ + D ++DFGL Sbjct: 132 DPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >2W1Z-A nrPDB Length = 368 Score = 47.6 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 49/322 (15%), Positives = 101/322 (31%), Gaps = 58/322 (18%) Query: 13 LNKTIWEVPERYQNLSPVGS--------------GAYGSVCAAFDTKTGL--RV------ 50 ++ +W + ++ S +G G+Y A D +TG V Sbjct: 36 VSTALWRNEQSFRVESELGERPRTLVRGPVLRDDGSY-ICLEATDQETGEPLEVHVPYFT 94 Query: 51 ------AVK---------KLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARS 95 A+K +L R ++ AK R + + +K ++ V R Sbjct: 95 ERPPSNAIKQLSEQVLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERD 154 Query: 96 LEEFNDVYLV------THLMGADLNNIVKCQKLTDDHVQF-LIYQILRGLKYIHSADIIH 148 + + +L H++G L + K H + L Q++R + ++H Sbjct: 155 MWVLSRFFLYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVH 214 Query: 149 RDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWM-HY------- 200 D + N+ +++ + + F + R + PE M Y Sbjct: 215 ADFQVRNILLDQRGGVFLTGFEHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTL 273 Query: 201 -NQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGT---PGAELLKKISSESAR 256 D W++G + + + ++ I R P LL+ S Sbjct: 274 MTFPFDTWTLGLAIYWIWCADLPNTEDAELGGIEWIYRRCKNIPQPVRALLEGFLRYSKE 333 Query: 257 NYIQSLTQMPKMNFANVFIGAN 278 + + L M + + + Sbjct: 334 DRLLPLQAMETSEYEQLRTELS 355 >4BWP-A nrPDB Length = 448 Score = 46.8 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 26/141 (18%), Positives = 43/141 (30%), Gaps = 38/141 (26%) Query: 39 CAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEE 98 A TG + L R + + + + + K ++H NV+ L +VFT + Sbjct: 67 YRATHNTTGYKY---CLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGD- 122 Query: 99 FNDVYLVTHLMGAD---LNNIV------------------------------KCQKLTDD 125 N + LV L L + Sbjct: 123 -NSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEA 181 Query: 126 HVQFLIYQILRGLKYIHSADI 146 + +I Q+ GLK IH A + Sbjct: 182 TIWSIIMQLTAGLKAIHHAGL 202 >3BYV-A nrPDB Length = 377 Score = 46.1 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 27/183 (14%), Positives = 60/183 (32%), Gaps = 15/183 (8%) Query: 110 GADLNNIVKCQKLTDDHVQF-LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILD 168 G L + K H + L Q++R L +H ++H L+P ++ +++ + + Sbjct: 190 GEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTG 249 Query: 169 FGLARHTDDEMTGYVATRWYRAPEIMLNWMHY----------NQTVDIWSVGCIMAELLT 218 F + V +R + PE+ + D W++G ++ + Sbjct: 250 FEHLVRDGARVVSSV-SRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWC 308 Query: 219 GRTLFPGTDHIDQLKLILRLVGT---PGAELLKKISSESARNYIQSLTQMPKMNFANVFI 275 + + I R P LL+ + + L M + + Sbjct: 309 ADLPITKDAALGGSEWIFRSCKNIPQPVRALLEGFLRYPKEDRLLPLQAMETPEYEQLRT 368 Query: 276 GAN 278 + Sbjct: 369 ELS 371 >3Q60-A nrPDB Length = 371 Score = 44.5 bits (104), Expect = 6e-05, Method: Composition-based stats. Identities = 45/331 (13%), Positives = 95/331 (28%), Gaps = 68/331 (20%) Query: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYREL-----RLL- 75 + + + P+ G V D + A+K + ++ E RLL Sbjct: 62 RKLKLVEPLRVGDRSVVFLVRDVERLEDFALKVFTMGAENSRSELERLHEATFAAARLLG 121 Query: 76 ---KHMKHENVIGL------------LDVFTPARSLEEFNDVYLVT-------HLMGADL 113 + + + L +P + + L+ L+ + L Sbjct: 122 ESPEEARDRRRLLLPSDAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAASVDLELLFSTL 181 Query: 114 NNIVKCQKLTDDHVQFLI-YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA 172 + + + ++ Q++R + S ++H P NL + D L + D Sbjct: 182 DFVYVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGD---- 237 Query: 173 RHTDDEMTGYVATRW--------YRAPEIM-LNWMHYNQTVDIWSVGCIMAELLTGRTLF 223 V TR Y E + + + ++ W +G + + F Sbjct: 238 ----VSALWKVGTRGPASSVPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPF 293 Query: 224 PGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVD 283 + TPG S + + + F + Sbjct: 294 --------------GLVTPG-------IKGSWKRPSLRVPGTDSLAFGSCTP-LPDFVKT 331 Query: 284 LLEKMLVLDSDKRITAAQALAHAYFAQYHDP 314 L+ + L D +R+ +A+ F Q + Sbjct: 332 LIGRFLNFDRRRRLLPLEAMETPEFLQLQNE 362 >4CZY-B nrPDB Length = 429 Score = 44.5 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 24/146 (16%), Positives = 54/146 (36%), Gaps = 26/146 (17%) Query: 39 CAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLL------KHMKHENVIGLLDVFTP 92 A + K G A++++ R E +L K + + N++ + + FT Sbjct: 61 YKAQNNKNGRHFALRRI--------EGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTT 112 Query: 93 ARSLEEFNDVYLVTHLMGADLNN-----------IVKCQKLTDDHVQFLIYQILRGLKYI 141 + H + L + + K+ ++ + + QI L I Sbjct: 113 EFFGDSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAI 172 Query: 142 HSADIIHRDLKPSNLAVNEDCELKIL 167 H+A + R L+ S + + E+ +++ Sbjct: 173 HNAKLAARCLELSKI-IWENNRIRLA 197 >6R5K-O nrPDB Length = 689 Score = 43.7 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 22/137 (16%), Positives = 50/137 (36%), Gaps = 11/137 (8%) Query: 39 CAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEE 98 F G +K+L ++ + + ++ + N+I D+F + + Sbjct: 311 FKVFSNYDGKAYVLKRLP-NIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDL 369 Query: 99 FNDVYLVTHLMGADL----NNIVKCQKL--TDDHVQFLIYQILRGLKYIHSADI-IHRDL 151 + LV L + V K T++++ + Q+ + IHS ++ I L Sbjct: 370 --SICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTL 427 Query: 152 KPSNLAVNED-CELKIL 167 + + D +K+ Sbjct: 428 NWRKVLITGDPGRIKLS 444 >3DZO-A nrPDB Length = 413 Score = 42.6 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 27/182 (14%), Positives = 56/182 (30%), Gaps = 14/182 (7%) Query: 110 GADLNNIVKCQKLTDDHVQF-LIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILD 168 G L + K H + L Q++R L +H ++H L+P ++ +++ + + Sbjct: 195 GEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTG 254 Query: 169 FGLARHTDDEMTGYVATRWYRAPEIMLNWM---------HYNQTVDIWSVGCIMAELLTG 219 F + R + PE M D W++G + + Sbjct: 255 FEHLVRDGASAVSPIG-RGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCA 313 Query: 220 RTLFPGTDHIDQLKLILRLVGT---PGAELLKKISSESARNYIQSLTQMPKMNFANVFIG 276 + + I R P LL+ + + L M + + Sbjct: 314 DLPNTDDAALGGSEWIFRSCKNIPQPVRALLEGFLRYPKEDRLLPLQAMETPEYEQLRTE 373 Query: 277 AN 278 + Sbjct: 374 LS 375 >4XR7-L nrPDB Length = 465 Score = 42.2 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 18/114 (15%), Positives = 42/114 (36%), Gaps = 9/114 (7%) Query: 39 CAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEE 98 F G +K+L ++ + + ++ + N+I D+F + + Sbjct: 87 FKVFSNYDGKAYVLKRLP-NIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDL 145 Query: 99 FNDVYLVTHLMGADL----NNIVKCQKL--TDDHVQFLIYQILRGLKYIHSADI 146 + LV L + V K T++++ + Q+ + IHS ++ Sbjct: 146 --SICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNL 197 >1TQM-A nrPDB Length = 282 Score = 41.8 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 32/168 (19%), Positives = 60/168 (35%), Gaps = 31/168 (18%) Query: 26 NLSPVGSGAYGSVCAAFDTKTGLRVA---------VKKLSRPFQ------SIIHAKRTYR 70 +G G +V + K G V KK+ S++ + Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 71 ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL 130 E R L+ ++ + P E N ++ L+ D + + + D V + Sbjct: 154 EFRALQKLQ--------GLAVPKVYAWEGNA--VLMELI--DAKELYRVRVENPDEVLDM 201 Query: 131 IYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE 178 IL + + I+H DL N+ V+E+ + I+DF + +E Sbjct: 202 ---ILEEVAKFYHRGIVHGDLSQYNVLVSEEG-IWIIDFPQSVEVGEE 245 >5YK0-A nrPDB Length = 452 Score = 41.1 bits (95), Expect = 9e-04, Method: Composition-based stats. Identities = 28/176 (15%), Positives = 47/176 (26%), Gaps = 51/176 (28%) Query: 36 GSVCAAFDTKTGLRVAVKKLSRPFQSII--HAKRTYRELRLLKHM--------------- 78 G V A G VAVK + K R + +LK + Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 79 -----------------------KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNN 115 H F + V + + G + Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPR-------FQVPHVVASAPKVVIQEWIEGVPMAE 257 Query: 116 IVKCQKLTD-DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFG 170 I++ D + L+ ++ ++H D P N + D + I+DFG Sbjct: 258 IIRHGTTEQRDLIGTLLAELT--FDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFG 311 >6FAI-l nrPDB Length = 425 Score = 35.3 bits (80), Expect = 0.044, Method: Composition-based stats. Identities = 24/173 (13%), Positives = 52/173 (30%), Gaps = 40/173 (23%) Query: 24 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKK-----------------LSRPFQSI---- 62 Y + +G G + D RV +K L + Q Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Query: 63 IHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL 122 + +E + + + + F + + +V L+ ++ K Sbjct: 154 LSRLAANKEYQFMSMLYSKG-------FKVPEPFDNSRHI-VVMELIEGYPMRRLRKHKN 205 Query: 123 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE------DCELKILDF 169 L+ I+ + ++ +IH D N+ + + DC ++DF Sbjct: 206 IPKLYSDLMCFIVD----LANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >6G18-v nrPDB Length = 552 Score = 34.1 bits (77), Expect = 0.090, Method: Composition-based stats. Identities = 17/102 (16%), Positives = 37/102 (36%), Gaps = 12/102 (11%) Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 +E +K L + P ++N +V L+ CQ + Sbjct: 158 AMKEFAYMK--------ALYERKFPVPKPIDYNRHAVVMELING----YPLCQIHHVEDP 205 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDF 169 + + + + + + +IH D NL ++E + ++DF Sbjct: 206 ASVYDEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 33.3 bits (75), Expect = 0.15, Method: Composition-based stats. Identities = 17/102 (16%), Positives = 37/102 (36%), Gaps = 12/102 (11%) Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 +E +K L + P ++N +V L+ CQ + Sbjct: 158 AMKEFAYMK--------ALYERKFPVPKPIDYNRHAVVMELING----YPLCQIHHVEDP 205 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDF 169 + + + + + + +IH D NL ++E + ++DF Sbjct: 206 ASVYDEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDF 247 >5N28-B nrPDB Length = 444 Score = 33.3 bits (75), Expect = 0.17, Method: Composition-based stats. Identities = 14/81 (17%), Positives = 28/81 (34%), Gaps = 3/81 (3%) Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL---TDDHVQFLIYQILRGL 138 N+ LL T L +V H + NI+ + F + + Sbjct: 174 NIASLLGAPTNLEGLGYALRNIMVNHYVATTKKNIMNAVAFASIMEQTAMFEMGDAIGSF 233 Query: 139 KYIHSADIIHRDLKPSNLAVN 159 + +H + ++ L NL ++ Sbjct: 234 ERLHLLGLAYQGLNADNLVID 254 >4BVU-A nrPDB Length = 211 Score = 32.2 bits (72), Expect = 0.33, Method: Composition-based stats. Identities = 24/148 (16%), Positives = 51/148 (34%), Gaps = 22/148 (14%) Query: 26 NLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIG 85 +G G+ + + + L + Y E+ + + E Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALY----------KKYDLIGNQYNEILEMAWQESE---- 89 Query: 86 LLDVFTPARS---LEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIH 142 L + F + ++ DVYL + + + + D+ + I + ++ Sbjct: 90 LFNAFYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICK----LN 145 Query: 143 SADIIHRDLKPSNLAVNEDCE-LKILDF 169 IIH DL N+ +++ E L +DF Sbjct: 146 ELSIIHYDLNTGNMLYDKESESLFPIDF 173 >4ESA-B nrPDB Length = 146 Score = 32.2 bits (72), Expect = 0.40, Method: Composition-based stats. Identities = 13/49 (26%), Positives = 24/49 (48%), Gaps = 6/49 (12%) Query: 33 GAYGSVCAAFDTKTGLRVA---VKK---LSRPFQSIIHAKRTYRELRLL 75 G++G++ A +VA +K L R +++ + K Y EL +L Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEIYAELSIL 91 >2Q0V-A nrPDB Length = 156 Score = 31.8 bits (71), Expect = 0.52, Method: Composition-based stats. Identities = 10/41 (24%), Positives = 15/41 (36%), Gaps = 6/41 (14%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAF 42 S R Y Q + VP ++ L + G G+V Sbjct: 8 SSGRENLYFQGI------VPRSFRLLDELERGQKGNVSEGV 42 >5JNE-A nrPDB Length = 367 Score = 31.0 bits (69), Expect = 0.92, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 35/95 (36%), Gaps = 10/95 (10%) Query: 76 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIYQ 133 K ++H +I + ++L E ++ L T L + + K + Q Sbjct: 158 KVLQHPKIIKQATLLYLKKTLREDEEMGLTTTSTIMSLQDPISYTRMKYPSKSINCKHLQ 217 Query: 134 ILRGLKYIHSA--------DIIHRDLKPSNLAVNE 160 L ++HS + D+ NLA++E Sbjct: 218 CFDALWFLHSQLQIPTWQCPVCQIDIALENLAISE 252 >6EF6-A nrPDB Length = 354 Score = 30.7 bits (68), Expect = 0.92, Method: Composition-based stats. Identities = 9/28 (32%), Positives = 16/28 (57%), Gaps = 3/28 (10%) Query: 145 DIIHRDLKPSNLAVNEDC---ELKILDF 169 +IH DL+ +NL V+ + ++DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >4FDJ-A nrPDB Length = 502 Score = 30.7 bits (68), Expect = 0.95, Method: Composition-based stats. Identities = 21/127 (16%), Positives = 37/127 (29%), Gaps = 27/127 (21%) Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDH--IDQLKLILRLVGTPGAELLK 248 PE++ + ++ V W +G R F H + G + Sbjct: 99 PELLKKAGYVSKIVGKWHLGH--------RPQFHPLKHGFDEWFGSPNCHFGPYDNKARP 150 Query: 249 KIS----SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304 I E Y + K AN+ A+D +++ QA Sbjct: 151 NIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKR-------------QARH 197 Query: 305 HAYFAQY 311 H +F + Sbjct: 198 HPFFLYW 204 >5N1Q-B nrPDB Length = 443 Score = 30.7 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 12/81 (14%), Positives = 28/81 (34%), Gaps = 3/81 (3%) Query: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL---TDDHVQFLIYQILRGL 138 N+ LL + L +V H + N++ + F + + Sbjct: 174 NIASLLGAPSNMEGLGYALRNIMVNHYVATTKKNLMNAVAFASIMEQTAMFEMGDAIGSF 233 Query: 139 KYIHSADIIHRDLKPSNLAVN 159 + +H + ++ L NL ++ Sbjct: 234 ERMHLLGLAYQGLNSDNLVID 254 >5I35-A nrPDB Length = 393 Score = 30.3 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 30/189 (15%), Positives = 51/189 (26%), Gaps = 51/189 (26%) Query: 36 GSVCAAFDTKTGLRVAVKK-----------------------------------LSRPFQ 60 G V A G VA+K + + Sbjct: 88 GQVHLARMKG-GREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRR 146 Query: 61 SIIHAKRTYRELRLLKHMK-----HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNN 115 + RE + + H + P E + L T L+ Sbjct: 147 ELALECDYQREAACARKFRDLLKGHPF------FYVPEIVDELCSPHVLTTELVSG--FP 198 Query: 116 IVKCQKLTDDHVQFLIYQIL-RGLKYIHSADIIHRDLKPSNLAVNEDCE-LKILDFGLAR 173 + + + L+ + + Y IL L+ + + D SN + + +LDFG R Sbjct: 199 LDQAEGLSQEIRNEICYNILVLCLRELFEFHFMQTDPNWSNFFYDPQQHKVALLDFGATR 258 Query: 174 HTDDEMTGY 182 D T Sbjct: 259 EYDRSFTDL 267 >2QG7-A nrPDB Length = 458 Score = 30.3 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 28/159 (17%), Positives = 54/159 (33%), Gaps = 45/159 (28%) Query: 46 TGLRVAVKKLSRPFQ--------SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLE 97 T + + VK +S+ + RE ++ + ++N+ + VF +E Sbjct: 121 TNILIKVKDMSKQAKYLIRLYGPKTDEIINREREKKISCILYNKNIAKKIYVFFTNGRIE 180 Query: 98 EFNDVYLV--THLMGADLNNIVKCQ-------KLTDDHVQFLIYQILRGL---------- 138 EF D Y + + ++ KL ++ + L Q+ + + Sbjct: 181 EFMDGYALSREDIKNPKFQKLIAKNLKLLHDIKLNENLYKEL--QVTQKVPGTRPSFLWN 238 Query: 139 ---KYIH-----SADIIHRDLKPSNLAVNEDCELKILDF 169 KY H I D K N+ K++DF Sbjct: 239 TIWKYFHLLNEERKKICSFDAKA-NIL-------KLIDF 269 >5LJ3-H nrPDB Length = 591 Score = 29.9 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 13/66 (19%), Positives = 29/66 (43%), Gaps = 6/66 (9%) Query: 114 NNIVKCQKLTDDHVQFLIYQILR--GLKYIHSADIIHRDLKPSNLAVNEDCELK-ILDFG 170 + +K Q+ + ++ + I+ + + + HRDL N+ + D K ++DF Sbjct: 8 DEDIKFQRENWEMIRSHVSPIISNLTMDNLQES---HRDLFQVNILIGRDIICKNVVDFT 64 Query: 171 LARHTD 176 L + Sbjct: 65 LNKQNG 70 >3G1Z-A nrPDB Length = 326 Score = 29.9 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 16/87 (18%), Positives = 31/87 (35%), Gaps = 1/87 (1%) Query: 219 GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES-ARNYIQSLTQMPKMNFANVFIGA 277 G L+ T +K +L P +L + +E R++ T + Sbjct: 69 GINLYLMTSPEYHMKRLLAAGCGPVFQLCRSFRNEEMGRHHNPEFTMLEWYRPHYDMYRL 128 Query: 278 NPLAVDLLEKMLVLDSDKRITAAQALA 304 DLL+++L + ++ QA Sbjct: 129 MNEVDDLLQQVLDCQPAESLSYQQAFQ 155 >5YJJ-A nrPDB Length = 713 Score = 29.5 bits (65), Expect = 2.3, Method: Composition-based stats. Identities = 27/140 (19%), Positives = 48/140 (34%), Gaps = 23/140 (16%) Query: 215 ELLTGRTLFPGTDHIDQL----KLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNF 270 E+L +F G + I +L + I+ + E + E ++SLT+ + Sbjct: 212 EML--EAIFFGHEEIKRLVAFQQEIIDHIQPIKQEFVPVERDEDLVEKVKSLTEDKGLK- 268 Query: 271 ANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDD-EPVADPYDQSFES 329 + +L D +R AL + D +D E + Sbjct: 269 ---------------DTVLTFDKQQRDENLDALKEEVVGHFLDEEDPENETLVKEVYAIL 313 Query: 330 RDLLIDEWKSLTYDEVISFV 349 DL+ +E + L DE I Sbjct: 314 NDLIKEEVRRLIADEKIRPD 333 >5JHE-A nrPDB Length = 397 Score = 29.5 bits (65), Expect = 2.3, Method: Composition-based stats. Identities = 17/55 (30%), Positives = 25/55 (45%), Gaps = 6/55 (10%) Query: 294 DKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISF 348 KR+ +AL F + +PDDE +Q E + LI+E K T + F Sbjct: 347 KKRL--DEALQDYIFCKEKNPDDE----VIEQRIEYVNRLIEENKEKTRKNISKF 395 >4BFR-A nrPDB Length = 952 Score = 29.1 bits (64), Expect = 3.2, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 28/68 (41%), Gaps = 12/68 (17%) Query: 103 YLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC 162 +L + G DL+ + ++ T + + + G+ HS N+ V + Sbjct: 766 WLKEYNSGDDLDRAI--EEFTLSCAGYCVASYVLGIGDRHS----------DNIMVKKTG 813 Query: 163 ELKILDFG 170 +L +DFG Sbjct: 814 QLFHIDFG 821 >6F1U-X nrPDB Length = 577 Score = 28.7 bits (63), Expect = 3.8, Method: Composition-based stats. Identities = 20/93 (21%), Positives = 37/93 (39%), Gaps = 9/93 (9%) Query: 51 AVK-----KLSRPFQSIIHAKRTYRELRLL----KHMKHENVIGLLDVFTPARSLEEFND 101 A+K K S Q II + E+++L + ++H L + ++EE D Sbjct: 232 ALKEDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQD 291 Query: 102 VYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQI 134 L+ G D + + +L V+ Q+ Sbjct: 292 RVLILERQGHDKDLQLHQSQLELQEVRLSYRQL 324 >5FBM-A nrPDB Length = 99 Score = 28.7 bits (63), Expect = 4.0, Method: Composition-based stats. Identities = 7/39 (17%), Positives = 15/39 (38%), Gaps = 6/39 (15%) Query: 25 QNLSPVGSGAYGSVC-----AAFDTKTGLRVAVKKLSRP 58 + + +G G + V + +TG + +K P Sbjct: 41 EKVQLIGFGNF-EVRERAARKGRNPQTGEEIKIKASKVP 78 >3NPK-A nrPDB Length = 291 Score = 28.7 bits (63), Expect = 4.0, Method: Composition-based stats. Identities = 11/45 (24%), Positives = 20/45 (44%), Gaps = 3/45 (6%) Query: 107 HLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDL 151 H L ++V+ K + + L++IH+ +IH DL Sbjct: 41 HFRAQLLLSVVQSNK---PELLNQALDVALALEFIHTYSLIHDDL 82 >4H05-A nrPDB Length = 273 Score = 28.7 bits (63), Expect = 4.2, Method: Composition-based stats. Identities = 9/27 (33%), Positives = 16/27 (59%), Gaps = 2/27 (7%) Query: 146 IIHRDLKPSNLAVNED-CELK-ILDFG 170 + H DL P N+ ++ CE+ ++D G Sbjct: 186 VCHGDLCPDNVLLDPRTCEVTGLIDVG 212 >4UP8-A nrPDB Length = 777 Score = 28.0 bits (61), Expect = 6.4, Method: Composition-based stats. Identities = 23/113 (20%), Positives = 41/113 (36%), Gaps = 14/113 (12%) Query: 225 GTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMN-----FANVFIGANP 279 G+ ++ ++ + ++L+K E S + + G N Sbjct: 304 GSTKLEIKDRLMDINNEEDIKMLEKFFKEPIPRPFNSAECSKVIEKHCTELNYYYDGNNE 363 Query: 280 LAV-----DLL-EKMLVLD---SDKRITAAQALAHAYFAQYHDPDDEPVADPY 323 A+ D + EK +VLD KRI+ AL + + P D P A + Sbjct: 364 KAMKKLFADFVTEKKMVLDFTAPFKRISYVHALEEKFGEKIPRPLDGPEALTF 416 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.149 0.458 Lambda K H 0.267 0.0455 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,921,063 Number of Sequences: 36641 Number of extensions: 697657 Number of successful extensions: 6149 Number of sequences better than 10.0: 521 Number of HSP's better than 10.0 without gapping: 922 Number of HSP's successfully gapped in prelim test: 64 Number of HSP's that attempted gapping in prelim test: 2157 Number of HSP's gapped (non-prelim): 1254 length of query: 360 length of database: 10,336,785 effective HSP length: 98 effective length of query: 262 effective length of database: 6,745,967 effective search space: 1767443354 effective search space used: 1767443354 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 60 (27.6 bits)