BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q15759 (364 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3GC9-A nrPDB 748 0.0 4EWQ-A nrPDB 580 e-166 3OHT-A nrPDB 572 e-163 1CM8-A nrPDB 494 e-140 4MYG-A nrPDB 458 e-129 5AWM-A nrPDB 342 1e-94 2XS0-A nrPDB 341 3e-94 1JNK-A nrPDB 339 1e-93 3E7O-A nrPDB 333 5e-92 4QTB-A nrPDB 326 1e-89 6DTL-A nrPDB 323 1e-88 3FI2-A nrPDB 322 2e-88 4IC8-A nrPDB 321 3e-88 4ZSG-A nrPDB 321 3e-88 5NGU-A nrPDB 320 4e-88 2F9G-A nrPDB 307 5e-84 5Z33-A nrPDB 298 3e-81 4QNY-A nrPDB 259 1e-69 4O2Z-A nrPDB 253 7e-68 3RP9-A nrPDB 243 1e-64 3OZ6-A nrPDB 241 2e-64 3PG1-A nrPDB 230 7e-61 3NIE-A nrPDB 210 7e-55 2I6L-A nrPDB 207 7e-54 3N9X-A nrPDB 202 2e-52 3NIZ-A nrPDB 186 1e-47 2BPM-A nrPDB 185 2e-47 1V0B-A nrPDB 181 4e-46 1UA2-A nrPDB 181 5e-46 4AU8-A nrPDB 172 2e-43 3EB0-A nrPDB 171 5e-43 6GU6-A nrPDB 170 1e-42 4E7W-A nrPDB 170 1e-42 4KRC-A nrPDB 165 3e-41 5AIR-A nrPDB 164 8e-41 1G3N-A nrPDB 157 9e-39 5G6V-A nrPDB 156 1e-38 5Y86-A nrPDB 155 2e-38 4BBM-A nrPDB 154 7e-38 3ZDU-A nrPDB 152 2e-37 4NST-A nrPDB 152 2e-37 5EFQ-A nrPDB 151 5e-37 4BGQ-A nrPDB 150 6e-37 3GC0-A nrPDB 150 1e-36 2W96-B nrPDB 148 4e-36 4AGU-A nrPDB 147 5e-36 3MIA-A nrPDB 147 7e-36 3E3P-A nrPDB 147 1e-35 6O6Q-A nrPDB 136 2e-32 5ZTN-A nrPDB 135 2e-32 5XVU-A nrPDB 134 7e-32 6HMD-A nrPDB 128 3e-30 3NCG-A nrPDB 124 5e-29 6EII-A nrPDB 124 5e-29 3DFA-A nrPDB 124 7e-29 4MD7-E nrPDB 123 1e-28 4CRL-A nrPDB 121 4e-28 3MA6-A nrPDB 120 1e-27 2PVN-A nrPDB 119 2e-27 5JN2-A nrPDB 119 2e-27 4RGJ-A nrPDB 117 1e-26 3IS5-A nrPDB 116 1e-26 2YCR-A nrPDB 112 2e-25 4LFI-A nrPDB 112 2e-25 3I6U-A nrPDB 110 8e-25 4IAN-A nrPDB 108 3e-24 3LIJ-A nrPDB 107 8e-24 2F57-A nrPDB 107 9e-24 2WO6-A nrPDB 106 2e-23 5X8I-B nrPDB 105 3e-23 3Q5I-A nrPDB 104 5e-23 4MVF-A nrPDB 103 9e-23 4YZB-A nrPDB 102 3e-22 4NIF-A nrPDB 102 3e-22 5D9K-A nrPDB 101 6e-22 4FIE-A nrPDB 101 7e-22 4KS7-A nrPDB 100 7e-22 3DXN-A nrPDB 100 8e-22 3D2K-A nrPDB 100 9e-22 6FYV-A nrPDB 100 1e-21 6FD3-A nrPDB 100 1e-21 4JDH-A nrPDB 100 1e-21 3RAW-A nrPDB 100 1e-21 3Q53-A nrPDB 100 1e-21 4WNO-A nrPDB 100 2e-21 2Q0N-A nrPDB 99 2e-21 3HZT-A nrPDB 99 3e-21 2OU7-A nrPDB 99 3e-21 4XBR-A nrPDB 99 3e-21 3H4J-B nrPDB 99 3e-21 4UZD-A nrPDB 99 4e-21 4J52-A nrPDB 98 5e-21 6E2O-A nrPDB 98 5e-21 5XZW-A nrPDB 97 1e-20 4B6L-A nrPDB 97 2e-20 3DB8-A nrPDB 97 2e-20 2Z7Q-A nrPDB 96 2e-20 6CMJ-A nrPDB 96 2e-20 4FG9-A nrPDB 96 2e-20 6QAU-A nrPDB 96 3e-20 4REW-A nrPDB 95 5e-20 4JG6-A nrPDB 94 8e-20 4PDS-A nrPDB 94 1e-19 4CFH-A nrPDB 94 1e-19 2A27-A nrPDB 93 2e-19 5TQX-A nrPDB 92 2e-19 1ZWS-A nrPDB 92 3e-19 5JZN-A nrPDB 92 4e-19 2Y7J-A nrPDB 92 4e-19 4RED-A nrPDB 92 5e-19 3KN6-A nrPDB 92 5e-19 3F3Z-A nrPDB 92 5e-19 2J90-A nrPDB 92 5e-19 1PHK-A nrPDB 91 6e-19 3MN3-A nrPDB 91 7e-19 4C0T-A nrPDB 91 8e-19 5F9E-A nrPDB 91 9e-19 1U5R-A nrPDB 91 9e-19 5U6Y-A nrPDB 91 9e-19 3HKO-A nrPDB 91 9e-19 2YAB-A nrPDB 91 1e-18 2VZ6-A nrPDB 91 1e-18 2GCD-A nrPDB 91 1e-18 2V7O-A nrPDB 90 1e-18 3GUB-A nrPDB 90 1e-18 4OW8-A nrPDB 90 2e-18 4YNZ-A nrPDB 90 2e-18 4X3F-A nrPDB 90 2e-18 4FR4-A nrPDB 90 2e-18 3BHH-A nrPDB 89 2e-18 2VN9-A nrPDB 89 2e-18 6B2Q-A nrPDB 89 3e-18 1ZXE-A nrPDB 89 4e-18 5YV8-A nrPDB 89 4e-18 5FG8-A nrPDB 89 4e-18 5UNP-A nrPDB 89 4e-18 2XNP-A nrPDB 89 4e-18 6CCF-A nrPDB 88 5e-18 6FDY-U nrPDB 88 6e-18 5ES1-A nrPDB 88 6e-18 3DAK-A nrPDB 88 6e-18 5D7A-A nrPDB 88 7e-18 6C9D-A nrPDB 87 9e-18 4I6B-A nrPDB 87 1e-17 2HAK-A nrPDB 87 1e-17 3SOA-A nrPDB 87 1e-17 2X4F-A nrPDB 87 1e-17 4CZT-A nrPDB 87 1e-17 2JC6-A nrPDB 87 1e-17 4CSV-A nrPDB 87 1e-17 5KZ7-A nrPDB 87 1e-17 3ORZ-A nrPDB 87 2e-17 4WB7-A nrPDB 86 2e-17 4L42-A nrPDB 86 2e-17 2QNJ-A nrPDB 86 2e-17 4JXF-A nrPDB 86 2e-17 2JAM-A nrPDB 86 3e-17 5X3F-B nrPDB 86 3e-17 1FOT-A nrPDB 86 3e-17 5DYK-A nrPDB 86 3e-17 5IG1-A nrPDB 86 3e-17 4D28-A nrPDB 85 4e-17 4RLP-A nrPDB 85 5e-17 5H2U-A nrPDB 85 5e-17 4KIK-B nrPDB 85 5e-17 5YKS-A nrPDB 85 6e-17 2WTK-C nrPDB 85 6e-17 2HW6-A nrPDB 84 7e-17 4CFF-A nrPDB 84 7e-17 3COM-A nrPDB 84 9e-17 5EZV-A nrPDB 84 1e-16 5FET-A nrPDB 84 1e-16 4EQM-A nrPDB 84 1e-16 1VZO-A nrPDB 84 1e-16 4TNB-A nrPDB 83 2e-16 2BDW-A nrPDB 83 2e-16 4APC-A nrPDB 83 2e-16 3KK8-A nrPDB 83 2e-16 3A4O-X nrPDB 82 2e-16 4U41-A nrPDB 82 3e-16 4AF3-A nrPDB 82 3e-16 3GQL-A nrPDB 82 3e-16 2JD5-A nrPDB 82 3e-16 2DQ7-X nrPDB 82 4e-16 5A46-A nrPDB 82 4e-16 5EG3-A nrPDB 82 4e-16 2BRG-A nrPDB 82 5e-16 6CQF-A nrPDB 82 5e-16 4LG4-A nrPDB 81 6e-16 4CQG-A nrPDB 81 7e-16 6AO5-A nrPDB 81 7e-16 3CJF-A nrPDB 81 7e-16 2YZA-A nrPDB 81 8e-16 3HDN-A nrPDB 81 9e-16 3TT0-A nrPDB 80 1e-15 2PSQ-A nrPDB 80 1e-15 5N23-A nrPDB 80 1e-15 3DLS-A nrPDB 80 2e-15 4B8L-A nrPDB 80 2e-15 1KOB-A nrPDB 80 2e-15 5DBX-A nrPDB 80 2e-15 4D2V-A nrPDB 79 2e-15 1S9I-A nrPDB 79 2e-15 3QA8-A nrPDB 79 2e-15 3UC3-A nrPDB 79 3e-15 2PL0-A nrPDB 79 3e-15 4M7I-A nrPDB 79 3e-15 2XIK-A nrPDB 79 3e-15 4QMW-A nrPDB 79 3e-15 2JDO-A nrPDB 79 4e-15 6CKI-A nrPDB 79 4e-15 2W4O-A nrPDB 79 4e-15 3DTC-A nrPDB 78 5e-15 4FZF-B nrPDB 78 5e-15 4K33-A nrPDB 78 5e-15 6ED6-A nrPDB 78 6e-15 5J5T-A nrPDB 78 7e-15 5LOH-A nrPDB 78 8e-15 4UY9-A nrPDB 78 8e-15 2HK5-A nrPDB 77 8e-15 6BDL-A nrPDB 77 9e-15 3A8W-A nrPDB 77 1e-14 5UUU-A nrPDB 77 1e-14 2H8H-A nrPDB 77 1e-14 5SYS-A nrPDB 77 1e-14 6GQK-A nrPDB 77 2e-14 3PVW-A nrPDB 77 2e-14 3LM0-A nrPDB 76 2e-14 4XCU-A nrPDB 76 2e-14 4AN9-A nrPDB 76 2e-14 6E9W-A nrPDB 76 2e-14 4UYA-A nrPDB 76 3e-14 6F3F-A nrPDB 75 4e-14 5WAX-A nrPDB 75 5e-14 5KKR-C nrPDB 75 5e-14 2WQN-A nrPDB 75 5e-14 1AD5-A nrPDB 75 5e-14 3UTO-A nrPDB 75 5e-14 1KOA-A nrPDB 75 6e-14 3PFQ-A nrPDB 74 7e-14 3LLT-A nrPDB 74 9e-14 3EQC-A nrPDB 74 1e-13 2I0E-A nrPDB 74 1e-13 5HI2-A nrPDB 74 1e-13 5VO2-A nrPDB 74 1e-13 5GRN-A nrPDB 74 1e-13 6GVJ-A nrPDB 74 1e-13 4YHJ-A nrPDB 73 2e-13 3TAC-A nrPDB 73 2e-13 3VN9-A nrPDB 73 2e-13 5TUR-A nrPDB 73 2e-13 1JPA-A nrPDB 72 3e-13 4WUA-A nrPDB 72 3e-13 4GS6-A nrPDB 72 3e-13 3FME-A nrPDB 72 3e-13 5O0Y-A nrPDB 72 4e-13 2UV2-A nrPDB 72 4e-13 3HMP-A nrPDB 72 5e-13 4RC3-A nrPDB 72 5e-13 3NYO-A nrPDB 72 5e-13 4RA4-A nrPDB 72 5e-13 2R2P-A nrPDB 72 5e-13 6NPU-A nrPDB 72 5e-13 5AP3-A nrPDB 72 5e-13 3BGP-A nrPDB 71 6e-13 5X5O-A nrPDB 71 7e-13 4XEY-B nrPDB 71 8e-13 3BEA-A nrPDB 71 8e-13 5KCV-A nrPDB 71 8e-13 3ORP-A nrPDB 71 9e-13 3MV5-A nrPDB 71 9e-13 4E93-A nrPDB 70 1e-12 6CTH-A nrPDB 70 1e-12 3C51-A nrPDB 70 1e-12 2OGV-A nrPDB 70 1e-12 2W1I-A nrPDB 70 1e-12 2ZMD-A nrPDB 70 1e-12 3UDB-A nrPDB 70 1e-12 6HXF-B nrPDB 70 2e-12 5HIE-A nrPDB 70 2e-12 5HVK-A nrPDB 70 2e-12 2XYN-A nrPDB 70 2e-12 3IO7-A nrPDB 70 2e-12 3DKO-A nrPDB 70 2e-12 2FO0-A nrPDB 70 2e-12 3TXO-A nrPDB 69 3e-12 3G0E-A nrPDB 69 3e-12 4Y83-A nrPDB 69 3e-12 5VD3-A nrPDB 69 3e-12 3ZUT-A nrPDB 69 4e-12 2A1A-B nrPDB 69 4e-12 1TKI-A nrPDB 68 5e-12 4P5Q-A nrPDB 68 5e-12 3UIU-A nrPDB 68 6e-12 2X7G-A nrPDB 68 7e-12 5L6P-A nrPDB 67 8e-12 3KRL-A nrPDB 67 9e-12 1K9A-A nrPDB 67 9e-12 2RIO-A nrPDB 67 1e-11 3OMV-A nrPDB 67 1e-11 4F9B-A nrPDB 67 1e-11 4NEU-A nrPDB 67 1e-11 2H34-A nrPDB 67 1e-11 1BYG-A nrPDB 67 1e-11 6DBN-A nrPDB 67 1e-11 5MJB-A nrPDB 67 2e-11 4XI2-A nrPDB 67 2e-11 6BXI-A nrPDB 67 2e-11 3PLS-A nrPDB 67 2e-11 3QD2-B nrPDB 67 2e-11 3PPZ-A nrPDB 67 2e-11 5TOS-A nrPDB 66 2e-11 6E4F-A nrPDB 66 2e-11 4R7H-A nrPDB 65 3e-11 4Y93-A nrPDB 65 4e-11 5U6B-A nrPDB 65 5e-11 2VWV-A nrPDB 65 5e-11 5AMN-A nrPDB 65 7e-11 5X02-A nrPDB 64 8e-11 2OZA-A nrPDB 64 8e-11 1NY3-A nrPDB 64 8e-11 3SOC-A nrPDB 64 1e-10 4YFF-A nrPDB 64 1e-10 3KA0-A nrPDB 64 1e-10 4CRS-A nrPDB 64 1e-10 4XUF-A nrPDB 64 1e-10 2Y6O-A nrPDB 64 1e-10 5E8V-A nrPDB 64 1e-10 5O2C-A nrPDB 64 1e-10 3VHK-A nrPDB 63 2e-10 1FVR-A nrPDB 63 2e-10 5O2B-A nrPDB 63 2e-10 4BTK-A nrPDB 63 2e-10 4X7Q-B nrPDB 63 2e-10 4NFN-A nrPDB 63 2e-10 3KUL-B nrPDB 63 2e-10 2BUJ-A nrPDB 63 3e-10 3SXS-A nrPDB 62 3e-10 4IDT-A nrPDB 62 4e-10 3MDY-A nrPDB 62 4e-10 4PDO-A nrPDB 62 5e-10 3FXW-A nrPDB 62 5e-10 3QGY-A nrPDB 62 5e-10 3TKU-A nrPDB 62 6e-10 5HLW-A nrPDB 61 6e-10 6FER-A nrPDB 61 6e-10 4M66-A nrPDB 61 6e-10 6DBM-A nrPDB 61 7e-10 5LPZ-A nrPDB 61 8e-10 4TPT-A nrPDB 61 9e-10 3ALO-A nrPDB 61 9e-10 6HV0-A nrPDB 61 9e-10 4PWN-A nrPDB 60 1e-09 5LPV-A nrPDB 60 1e-09 4AT3-A nrPDB 60 1e-09 4AW2-A nrPDB 60 1e-09 4JLC-A nrPDB 60 2e-09 5FM2-A nrPDB 60 2e-09 4OLI-A nrPDB 60 2e-09 4PL5-B nrPDB 60 2e-09 4EUU-A nrPDB 59 2e-09 4EUT-A nrPDB 59 3e-09 3C1X-A nrPDB 59 3e-09 5UIU-A nrPDB 59 3e-09 2PMN-X nrPDB 59 3e-09 4OTD-A nrPDB 59 3e-09 3Q4U-A nrPDB 59 4e-09 4FL3-A nrPDB 59 4e-09 2J0K-A nrPDB 59 4e-09 3PP0-A nrPDB 59 4e-09 6NT9-A nrPDB 59 4e-09 5XD6-A nrPDB 59 4e-09 4EBW-A nrPDB 59 4e-09 6FEX-A nrPDB 59 5e-09 4G3E-A nrPDB 58 5e-09 4HVI-A nrPDB 58 5e-09 4C59-A nrPDB 58 5e-09 2QLU-A nrPDB 58 6e-09 3V5Q-A nrPDB 58 6e-09 5C26-A nrPDB 58 7e-09 5B2L-A nrPDB 58 7e-09 6O8B-A nrPDB 58 8e-09 2OZO-A nrPDB 57 9e-09 3HNG-A nrPDB 57 1e-08 6BSD-A nrPDB 57 1e-08 1U59-A nrPDB 57 1e-08 3LZB-A nrPDB 57 1e-08 4E20-A nrPDB 56 3e-08 2QKW-B nrPDB 55 5e-08 2VD5-A nrPDB 55 6e-08 5GNK-A nrPDB 55 7e-08 1LUF-A nrPDB 54 8e-08 4XLV-A nrPDB 54 8e-08 5WNO-A nrPDB 54 8e-08 3M42-A nrPDB 54 1e-07 3ZZW-A nrPDB 54 2e-07 3QUP-A nrPDB 53 2e-07 4CI6-B nrPDB 53 2e-07 3BBT-B nrPDB 53 2e-07 4LQP-A nrPDB 53 2e-07 5X1R-A nrPDB 52 3e-07 4LRM-A nrPDB 52 3e-07 2WTK-B nrPDB 52 3e-07 2C47-A nrPDB 52 3e-07 5IKW-A nrPDB 52 4e-07 5CLR-A nrPDB 52 4e-07 2Y4I-B nrPDB 52 4e-07 5L2Q-C nrPDB 52 4e-07 4RT7-A nrPDB 52 4e-07 5KMM-A nrPDB 52 6e-07 5FQD-C nrPDB 51 6e-07 3SV0-A nrPDB 51 7e-07 5U6C-A nrPDB 51 8e-07 5J0A-A nrPDB 51 9e-07 3UIM-A nrPDB 51 1e-06 3G2F-A nrPDB 50 1e-06 4Y12-A nrPDB 50 1e-06 2PZI-A nrPDB 50 1e-06 4F0G-A nrPDB 50 2e-06 5TE0-A nrPDB 50 2e-06 3I81-A nrPDB 50 2e-06 6J5U-C nrPDB 50 2e-06 2CHL-A nrPDB 49 3e-06 3MY0-A nrPDB 49 5e-06 4L68-A nrPDB 48 6e-06 5VC6-A nrPDB 48 6e-06 2CMW-A nrPDB 48 7e-06 4H1J-A nrPDB 48 7e-06 1PY5-A nrPDB 48 8e-06 5AR8-A nrPDB 47 1e-05 4M69-B nrPDB 47 1e-05 4JRN-A nrPDB 47 2e-05 4NT4-A nrPDB 46 2e-05 3LMG-A nrPDB 46 2e-05 5CEK-A nrPDB 46 2e-05 3ZBF-A nrPDB 46 3e-05 4BTF-A nrPDB 46 3e-05 6DC0-A nrPDB 45 4e-05 4TN6-A nrPDB 45 5e-05 1U54-B nrPDB 45 5e-05 5WNL-A nrPDB 45 5e-05 4HZS-A nrPDB 45 6e-05 4IX6-A nrPDB 44 2e-04 4XHH-A nrPDB 42 4e-04 4XHL-A nrPDB 41 6e-04 6BFN-A nrPDB 40 0.002 1CSN-A nrPDB 39 0.003 2RSV-A nrPDB 37 0.009 5M07-A nrPDB 37 0.011 2LAV-A nrPDB 37 0.013 5VDK-A nrPDB 36 0.030 6G4J-A nrPDB 35 0.041 5X18-A nrPDB 35 0.062 5UU1-A nrPDB 35 0.072 6EQI-C nrPDB 35 0.074 4AZV-A nrPDB 34 0.080 4AZW-A nrPDB 34 0.11 5OAT-A nrPDB 34 0.12 6EWX-A nrPDB 33 0.13 5VE6-A nrPDB 33 0.14 3ENH-A nrPDB 33 0.17 4G7X-B nrPDB 33 0.22 6FW4-A nrPDB 32 0.41 2E5M-A nrPDB 31 0.68 6M7Z-A nrPDB 31 0.78 4O1O-A nrPDB 31 0.81 5DMZ-A nrPDB 30 1.7 5UV4-A nrPDB 30 2.2 5XYI-G nrPDB 29 3.6 6CHJ-A nrPDB 29 4.1 6J6I-B nrPDB 28 4.4 5H6O-A nrPDB 28 4.5 4OAU-C nrPDB 28 5.4 4BWP-A nrPDB 28 6.0 >3GC9-A nrPDB Length = 370 Score = 748 bits (1930), Expect = 0.0, Method: Compositional matrix adjust. Identities = 362/364 (99%), Positives = 362/364 (99%) Query: 1 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 60 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ Sbjct: 7 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 66 Query: 61 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ 120 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK Q Sbjct: 67 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQ 126 Query: 121 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT 180 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED ELRILDFGLARQADEEMT Sbjct: 127 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMT 186 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG Sbjct: 187 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 246 Query: 241 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 300 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA Sbjct: 247 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 306 Query: 301 EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL 360 EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL Sbjct: 307 EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL 366 Query: 361 EIEQ 364 EIEQ Sbjct: 367 EIEQ 370 >4EWQ-A nrPDB Length = 383 Score = 580 bits (1495), Expect = e-166, Method: Compositional matrix adjust. Identities = 264/350 (75%), Positives = 311/350 (88%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 61 S R FYRQELNKT+WEVP+R Q L PVGSGAYGSVC+A+D + +VAVKKLSRPFQS Sbjct: 25 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 84 Query: 62 LIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA 121 +IHA+RTYRELRLLKH+KHENVIGLLDVFTPA S+E+F++VYLVT LMGADLNNIVKCQ Sbjct: 85 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 144 Query: 122 LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTG 181 L+D+HVQFL+YQ+LRGLKYIHSA IIHRDLKPSN+AVNEDCEL+ILDFGLAR D+EMTG Sbjct: 145 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG 204 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGT 241 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL G+ LFPG+D+IDQLK I+ +VGT Sbjct: 205 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGT 264 Query: 242 PSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAE 301 P E+L KISSE AR YIQSL MP+ + +++F GANPLA+DLL +MLVLDSD+R++AA+ Sbjct: 265 PGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQ 324 Query: 302 ALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPP 351 ALAHAYF+QYHDP+DEP A+PYD+S E+++ ++EWK LTY EV+SF PP Sbjct: 325 ALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPP 374 >3OHT-A nrPDB Length = 389 Score = 572 bits (1473), Expect = e-163, Method: Compositional matrix adjust. Identities = 257/347 (74%), Positives = 308/347 (88%) Query: 5 RAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH 64 R FYRQELNKT+WEVP+R Q L PVGSGAYGSVCS+YD + K+AVKKLSRPFQS+IH Sbjct: 34 RPTFYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIH 93 Query: 65 ARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSD 124 A+RTYRELRLLKH+KHENVIGLLDVFTPATS+E+F++VYLVT LMGADLNNIVKCQ L+D Sbjct: 94 AKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKLTD 153 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVA 184 +HVQFL+YQ+LRGLKYIHSA IIHRDLKPSN+AVNEDCEL+ILDFGLAR D+EMTGYVA Sbjct: 154 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVA 213 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSP 244 TRWYRAPEIMLNWMHYN TVDIWSVGCIMAELL G+ LFPG+D+I+QL++IM + GTP Sbjct: 214 TRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPA 273 Query: 245 EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 V++++ S AR YI SLP MP+++ + +F GANPLA+DLL +MLVLD+D+R++A+EALA Sbjct: 274 SVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALA 333 Query: 305 HAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPP 351 H YFSQYHDP+DEPE+EPYD+S E+++ +EEWK LTY+EV SF+ P Sbjct: 334 HPYFSQYHDPDDEPESEPYDQSFESRQLEIEEWKRLTYEEVCSFETP 380 >1CM8-A nrPDB Length = 367 Score = 494 bits (1272), Expect = e-140, Method: Compositional matrix adjust. Identities = 225/354 (63%), Positives = 284/354 (80%), Gaps = 3/354 (0%) Query: 1 MSGP---RAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR 57 MS P R+GFYRQE+ KT WEV + L+PVGSGAYG+VCSA D R KVA+KKL R Sbjct: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 Query: 58 PFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV 117 PFQS + A+R YRELRLLKH++HENVIGLLDVFTP +++DF++ YLV MG DL ++ Sbjct: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120 Query: 118 KCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE 177 K + L ++ +QFLVYQ+L+GL+YIH+AGIIHRDLKP N+AVNEDCEL+ILDFGLARQAD Sbjct: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180 Query: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME 237 EMTGYV TRWYRAPE++LNWM Y QTVDIWSVGCIMAE++ GK LF GSD++DQLK IM+ Sbjct: 181 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 Query: 238 VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV 297 V GTP E + ++ S+ A+ Y++ LP + +KD +SI A+PLA++LL +MLVLD++QRV Sbjct: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 Query: 298 SAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPP 351 +A EALAH YF HD EDEP+ + YD+S + +RTL+EWK +TY+EVLSFKPP Sbjct: 301 TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354 >4MYG-A nrPDB Length = 372 Score = 458 bits (1178), Expect = e-129, Method: Compositional matrix adjust. Identities = 210/347 (60%), Positives = 275/347 (79%), Gaps = 2/347 (0%) Query: 5 RAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH 64 + GFY+Q++NKT WE+P+ VGSGAYGSVCSA D R +KVA+KKLSRPFQS I Sbjct: 26 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 85 Query: 65 ARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSD 124 A+R YREL LLKH++HENVIGLLDVFTPA+S+ +F + YLV M DL I+ + S+ Sbjct: 86 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSE 144 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVA 184 E +Q+LVYQ+L+GLKYIHSAG++HRDLKP N+AVNEDCEL+ILDFGLAR AD EMTGYV Sbjct: 145 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV 204 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSP 244 TRWYRAPE++L+WMHYNQTVDIWSVGCIMAE+L GK LF G DY+DQL +I++V G P Sbjct: 205 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 264 Query: 245 EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 E + K++ + A++YIQSLP P+KD + +F A+P A DLL +ML LD D+R++AA+AL Sbjct: 265 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 324 Query: 305 HAYFSQYHDPEDEPEA-EPYDESVEAKERTLEEWKELTYQEVLSFKP 350 H +F + DPE+E EA +P+D+S+E ++ T++EWK+ Y+E+++F P Sbjct: 325 HPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 371 >5AWM-A nrPDB Length = 394 Score = 342 bits (878), Expect = 1e-94, Method: Compositional matrix adjust. Identities = 171/366 (46%), Positives = 242/366 (66%), Gaps = 20/366 (5%) Query: 1 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 60 M+ + Y E+ T + + R LRP+GSGA G VC+AYD +Q VA+KKLSRPFQ Sbjct: 23 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ 82 Query: 61 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ 120 ++ HA+R YRE +L+K + H+N+IGLL+ FTP ++E+F +VYLV LM A+L +++ Sbjct: 83 NVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD 142 Query: 121 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE-- 178 L + + +L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A Sbjct: 143 -LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM 201 Query: 179 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 238 MT YV TR+YRAPE++L M Y + VDIWSVGCIM E+++G LFPG+D+IDQ +I+E Sbjct: 202 MTPYVVTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 260 Query: 239 VGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIF-------------RGANPLAIDLL 285 +GTPSP + ++ R Y+++ P +F R A +LL Sbjct: 261 LGTPSPSFMQRLQPT-VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLL 319 Query: 286 GRMLVLDSDQRVSAAEALAHAYFSQYHDPE--DEPEAEPYDESVEAKERTLEEWKELTYQ 343 +MLV+D +QR+S EAL H Y + ++D E D P EPYD SV+ +E T+E+WKEL Y+ Sbjct: 320 SKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYE 379 Query: 344 EVLSFK 349 EV+ ++ Sbjct: 380 EVMDYE 385 >2XS0-A nrPDB Length = 386 Score = 341 bits (874), Expect = 3e-94, Method: Compositional matrix adjust. Identities = 173/360 (48%), Positives = 243/360 (67%), Gaps = 21/360 (5%) Query: 7 GFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR 66 FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ HA+ Sbjct: 11 NFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAK 70 Query: 67 RTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEH 126 R YREL L+K + H+N+IGLL+VFTP S+E+F +VY+V LM A+L +++ + L E Sbjct: 71 RAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHER 129 Query: 127 VQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVA 184 + +L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A M +V Sbjct: 130 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVV 189 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSP 244 TR+YRAPE++L M Y + VDIWSVGCIM E+++G LFPG+D+IDQ +++E +GTP P Sbjct: 190 TRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCP 248 Query: 245 EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGA--------NPL----AIDLLGRMLVLD 292 E + K+ RTY+++ P +F N L A DLL +MLV+D Sbjct: 249 EFMKKLQPT-VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVID 307 Query: 293 SDQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQEVLSFK 349 + +R+S EAL H Y + ++DP E EA P D+ ++ +E T+EEWKEL Y+EV+ + Sbjct: 308 ASKRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 366 >1JNK-A nrPDB Length = 423 Score = 339 bits (869), Expect = 1e-93, Method: Compositional matrix adjust. Identities = 174/357 (48%), Positives = 242/357 (67%), Gaps = 21/357 (5%) Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67 FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ HA+R Sbjct: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127 YREL L+K + H+N+I LL+VFTP ++E+F +VYLV LM A+L +++ + L E + Sbjct: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 166 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVAT 185 +L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A MT YV T Sbjct: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245 R+YRAPE++L M Y + VDIWSVGCIM E+++ K LFPG DYIDQ +++E +GTP PE Sbjct: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGA--------NPL----AIDLLGRMLVLDS 293 + K+ R Y+++ P +F + N L A DLL +MLV+D Sbjct: 286 FMKKLQPT-VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 Query: 294 DQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQEVLS 347 +R+S +AL H Y + ++DP E EA P YD+ ++ +E T+EEWKEL Y+EV++ Sbjct: 345 AKRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 >3E7O-A nrPDB Length = 360 Score = 333 bits (855), Expect = 5e-92, Method: Compositional matrix adjust. Identities = 172/356 (48%), Positives = 236/356 (66%), Gaps = 21/356 (5%) Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67 FY ++ + + V +R Q L+P+GSGA G VC+A+D L VAVKKLSRPFQ+ HA+R Sbjct: 8 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 67 Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127 YREL LLK + H+N+I LL+VFTP ++E+F +VYLV LM A+L ++ + L E + Sbjct: 68 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERM 126 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVAT 185 +L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A MT YV T Sbjct: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVT 186 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245 R+YRAPE++L M Y + VDIWSVGCIM EL++G +F G+D+IDQ +++E +GTPS E Sbjct: 187 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAE 245 Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIF------------RGANPLAIDLLGRMLVLDS 293 +A + R Y+++ P P +F + A DLL +MLV+D Sbjct: 246 FMAALQPT-VRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 304 Query: 294 DQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQEVL 346 D+R+S EAL H Y + ++DP E EA P YD +E +E +EEWKEL Y+EV+ Sbjct: 305 DKRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKEVM 359 >4QTB-A nrPDB Length = 380 Score = 326 bits (835), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 162/340 (47%), Positives = 231/340 (67%), Gaps = 9/340 (2%) Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77 ++V R L+ +G GAYG V SAYD + +VA+KK+S PF+ + +RT RE+++L Sbjct: 37 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 95 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRG 137 +HENVIG+ D+ A+++E +VY+V LM DL ++K Q LS++H+ + +YQ+LRG Sbjct: 96 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 154 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE------MTGYVATRWYRAP 191 LKYIHSA ++HRDLKPSN+ +N C+L+I DFGLAR AD E +T YVATRWYRAP Sbjct: 155 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 214 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 EIMLN Y +++DIWSVGCI+AE+L + +FPG Y+DQL I+ ++G+PS E L I Sbjct: 215 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 274 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 + AR Y+QSLP + + +F ++ A+DLL RML + ++R++ EALAH Y QY Sbjct: 275 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 334 Query: 312 HDPEDEPEA-EPYDESVEAKERTLEEWKELTYQEVLSFKP 350 +DP DEP A EP+ ++E + E KEL +QE F+P Sbjct: 335 YDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQP 374 >6DTL-A nrPDB Length = 364 Score = 323 bits (827), Expect = 1e-88, Method: Compositional matrix adjust. Identities = 158/348 (45%), Positives = 233/348 (66%), Gaps = 7/348 (2%) Query: 8 FYRQELNKTVWEVPQRLQG-LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR 66 F + + ++EV + + + P+G GAYG VCSA ++ + VA+KK++ F + I A+ Sbjct: 15 FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK 74 Query: 67 RTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-QALSDE 125 RT RE++LL+H+ HEN++ + D+ P F++VY+ LM DL+ I++ QALS+E Sbjct: 75 RTLREIKLLRHMDHENIVAIRDIIPPPLR-NAFNDVYIAYELMDTDLHQIIRSNQALSEE 133 Query: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYV 183 H Q+ +YQ+LRGLKYIHSA ++HRDLKPSN+ +N +C+L+I DFGLAR E MT YV Sbjct: 134 HCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYV 193 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPS 243 TRWYRAPE++LN Y +D+WSVGCI EL+ K LFPG D++ QL+ +ME++GTPS Sbjct: 194 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS 253 Query: 244 PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEAL 303 E + +E+A+ YI+ LPP P++ ++ F +PLAIDL+ +ML D +R++ +AL Sbjct: 254 -EEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 312 Query: 304 AHAYFSQYHDPEDEPEAE-PYDESVEAKERTLEEWKELTYQEVLSFKP 350 AH Y + HD DEPE P++ E + E+ KEL Y+E L+F P Sbjct: 313 AHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNP 360 >3FI2-A nrPDB Length = 353 Score = 322 bits (825), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 166/354 (46%), Positives = 232/354 (65%), Gaps = 26/354 (7%) Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67 FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ HA+R Sbjct: 10 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 69 Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127 YREL L+K + H+N+I LL+VFTP ++E+F +VYLV LM A+L +++ + L E + Sbjct: 70 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 128 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVAT 185 +L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A MT YV T Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 188 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245 R+YRAPE++L M Y + VDIWSVGCIM E+++ K LFPG DYIDQ +++E +GTP PE Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 247 Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGA--------NPL----AIDLLGRMLVLDS 293 + K+ R Y+++ P +F + N L A DLL +MLV+D Sbjct: 248 FMKKLQPT-VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 306 Query: 294 DQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLS 347 +R+S +AL H Y + ++ + +E T+EEWKEL Y+EV++ Sbjct: 307 AKRISVDDALQHPYINVWYXXX---------XXXDEREHTIEEWKELIYKEVMN 351 >4IC8-A nrPDB Length = 442 Score = 321 bits (823), Expect = 3e-88, Method: Compositional matrix adjust. Identities = 161/342 (47%), Positives = 226/342 (66%), Gaps = 9/342 (2%) Query: 16 TVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLL 75 ++V + + +G+GAYG V SA Q+VA+KK+ F + +A+RT REL++L Sbjct: 49 VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKIL 108 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV-KCQALSDEHVQFLVYQL 134 KH KH+N+I + D+ P +F VY+V LM +DL+ I+ Q L+ EHV++ +YQL Sbjct: 109 KHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQL 168 Query: 135 LRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ-----ADEE--MTGYVATRW 187 LRGLKY+HSA +IHRDLKPSN+ VNE+CEL+I DFG+AR A+ + MT YVATRW Sbjct: 169 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 228 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 247 YRAPE+ML+ Y Q +D+WSVGCI E+L + LFPG +Y+ QL+ IM V+GTPSP V+ Sbjct: 229 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 288 Query: 248 AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 + +E R YIQSLPP +++ GA+ A+ LLGRML + R+SAA AL H + Sbjct: 289 QAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPF 348 Query: 308 FSQYHDPEDEPE-AEPYDESVEAKERTLEEWKELTYQEVLSF 348 ++YHDP+DEP+ A P+D + + + T E KE E+ F Sbjct: 349 LAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 390 >4ZSG-A nrPDB Length = 347 Score = 321 bits (823), Expect = 3e-88, Method: Compositional matrix adjust. Identities = 161/342 (47%), Positives = 226/342 (66%), Gaps = 9/342 (2%) Query: 16 TVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLL 75 ++V + + +G+GAYG V SA Q+VA+KK+ F + +A+RT REL++L Sbjct: 1 VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKIL 60 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV-KCQALSDEHVQFLVYQL 134 KH KH+N+I + D+ P +F VY+V LM +DL+ I+ Q L+ EHV++ +YQL Sbjct: 61 KHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQL 120 Query: 135 LRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ-----ADEE--MTGYVATRW 187 LRGLKY+HSA +IHRDLKPSN+ VNE+CEL+I DFG+AR A+ + MT YVATRW Sbjct: 121 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 180 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 247 YRAPE+ML+ Y Q +D+WSVGCI E+L + LFPG +Y+ QL+ IM V+GTPSP V+ Sbjct: 181 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 240 Query: 248 AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 + +E R YIQSLPP +++ GA+ A+ LLGRML + R+SAA AL H + Sbjct: 241 QAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPF 300 Query: 308 FSQYHDPEDEPE-AEPYDESVEAKERTLEEWKELTYQEVLSF 348 ++YHDP+DEP+ A P+D + + + T E KE E+ F Sbjct: 301 LAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 342 >5NGU-A nrPDB Length = 381 Score = 320 bits (821), Expect = 4e-88, Method: Compositional matrix adjust. Identities = 160/341 (46%), Positives = 228/341 (66%), Gaps = 9/341 (2%) Query: 17 VWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLK 76 V++V R L +G GAYG VCSAYD + +VA+KK+S PF+ + +RT RE+++L Sbjct: 37 VFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLREIKILL 95 Query: 77 HLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLR 136 +HEN+IG+ D+ A +IE +VY+V LM DL ++K Q LS++H+ + +YQ+LR Sbjct: 96 RFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILR 154 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE------MTGYVATRWYRA 190 GLKYIHSA ++HRDLKPSN+ +N C+L+I DFGLAR AD + +T YVATRWYRA Sbjct: 155 GLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRA 214 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI 250 PEIMLN Y +++DIWSVGCI+AE+L + +FPG Y+DQL I+ ++G+PS E L I Sbjct: 215 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 274 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + AR Y+ SLP + + +F A+ A+DLL +ML + +R+ +ALAH Y Q Sbjct: 275 INLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 334 Query: 311 YHDPEDEPEAE-PYDESVEAKERTLEEWKELTYQEVLSFKP 350 Y+DP DEP AE P+ +E + E+ KEL ++E F+P Sbjct: 335 YYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQP 375 >2F9G-A nrPDB Length = 353 Score = 307 bits (786), Expect = 5e-84, Method: Compositional matrix adjust. Identities = 159/354 (44%), Positives = 216/354 (61%), Gaps = 25/354 (7%) Query: 15 KTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRL 74 + V+ + Q +G GAYG VCSA + VA+KK+ PF + A RT RE+++ Sbjct: 4 RIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKI 62 Query: 75 LKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQL 134 LKH KHEN+I + ++ P S E+F+EVY++ LM DL+ ++ Q LSD+H+Q+ +YQ Sbjct: 63 LKHFKHENIITIFNIQRP-DSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQT 121 Query: 135 LRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE-------------MTG 181 LR +K +H + +IHRDLKPSN+ +N +C+L++ DFGLAR DE MT Sbjct: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGT 241 YVATRWYRAPE+ML Y++ +D+WS GCI+AEL + +FPG DY QL I ++GT Sbjct: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 Query: 242 P-SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 300 P S L I S AR YI+SLP P L +F NP IDLL RMLV D +R++A Sbjct: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 Query: 301 EALAHAYFSQYHDPEDEPEAEP-------YDESVEAKERTLEEWKELTYQEVLS 347 EAL H Y YHDP DEPE EP +D EA T ++ K+L + E+ S Sbjct: 302 EALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEA--LTTKDLKKLIWNEIFS 353 >5Z33-A nrPDB Length = 425 Score = 298 bits (762), Expect = 3e-81, Method: Compositional matrix adjust. Identities = 154/340 (45%), Positives = 217/340 (63%), Gaps = 13/340 (3%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 V +R + +G GAYG VC+A + + + VA+KK++ F I A+R RE++LL+H + Sbjct: 29 VDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFR 88 Query: 80 -HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-QALSDEHVQFLVYQLLRG 137 H N+ L D+ P ++F+E YL LM DL I++ Q L+D H Q +YQ+L G Sbjct: 89 GHRNITCLYDMDIPRP--DNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCG 146 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR--QADEE-----MTGYVATRWYRA 190 LKYIHSA ++HRDLKP N+ VN DCEL+I DFGLAR D E MT YVATRWYRA Sbjct: 147 LKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRA 206 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI 250 PEIML++ Y + +D+WSVGCI+AELL G+ F G DY+DQL +I+ ++GTP+ E L++I Sbjct: 207 PEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRI 266 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 S A+ Y+++LP M +K ++F ANP A+DLL RML D R+S +AL H Y Sbjct: 267 GSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYLHI 326 Query: 311 YHDPEDEPEA-EPYDESVEAKERTLEEWKELTYQEVLSFK 349 +HD DEP+ ++ E E + E +++ EV F+ Sbjct: 327 WHDASDEPDCPTTFNFDFEVVE-DVGEMRKMILDEVYRFR 365 >4QNY-A nrPDB Length = 354 Score = 259 bits (663), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 129/343 (37%), Positives = 210/343 (61%), Gaps = 7/343 (2%) Query: 12 ELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQK-VAVKKLSRP-FQSLIHARRTY 69 EL V + R R +G+G+YG V A D + + VA+K++++ F+ +I A+R Sbjct: 10 ELQAEVCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRIL 69 Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-QALSDEHVQ 128 RE++LL H +N+IGL ++ TP E+F Y+V +M DL +++ Q L++ H+Q Sbjct: 70 REIKLLAHFNDDNIIGLRNILTPEDP-ENFDHFYIVMDIMETDLKQVLRSGQELTEAHIQ 128 Query: 129 FLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE---MTGYVAT 185 F +YQ LR L IHSAG+IHRD+ P+N+ VN +C+L+I DFGLA++ +++ MT YV Sbjct: 129 FFIYQALRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTM 188 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245 RWYRAPE+++ Y+ +D+W +GCI+ ELL + LF G D ++QL +I++V+GTPS E Sbjct: 189 RWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEE 248 Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAH 305 + + S A+ Y++ PQ D + A+P A+DLL MLV + +R++ +A+ H Sbjct: 249 DINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRH 308 Query: 306 AYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSF 348 + Q HD D+ + E +++T+ + K Y+E + F Sbjct: 309 PFLEQLHDDADDNLSYALFRFDENEQKTIVDVKRAIYEESVKF 351 >4O2Z-A nrPDB Length = 377 Score = 253 bits (647), Expect = 7e-68, Method: Compositional matrix adjust. Identities = 132/343 (38%), Positives = 203/343 (59%), Gaps = 16/343 (4%) Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77 +EVP + L+ +G GAYG CS D +KV++KK F+ + +R RE+ +++ Sbjct: 41 FEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRF 100 Query: 78 LKHENVIGLLDVFTP-ATSIEDFSEVYLVTTLMGADLNNIVKC-QALSDEHVQFLVYQLL 135 HEN++ ++++ P F +VY+VT LM D+N +++ Q L + H+Q+ VYQ+L Sbjct: 101 FHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQVLEESHMQYFVYQIL 160 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD---EEMTGYVATRWYRAPE 192 RGLKY+HSA + HRDLKP+N+ N CEL+I+DFGL+R D E+T YV TRWYR PE Sbjct: 161 RGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPE 220 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 ++L +Y+ VDIWSVGCI AE+ K +FPG + +DQL+ I + +G P ++ Sbjct: 221 LLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIV----- 275 Query: 253 EHARTYIQSLPPMPQKDLS--SIFRG--ANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 EH R ++ L +P L+ + G N ID L +M LD +R +AA+ LAH Y Sbjct: 276 EH-REALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYL 334 Query: 309 SQYHDPEDEPEAE-PYDESVEAKERTLEEWKELTYQEVLSFKP 350 + HD EDEP P+ + E+ + E + + +++ + P Sbjct: 335 AHLHDEEDEPTCPCPFLWAHESTPMGVSELRRAFWADIVDYNP 377 >3RP9-A nrPDB Length = 458 Score = 243 bits (619), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 130/365 (35%), Positives = 198/365 (54%), Gaps = 63/365 (17%) Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77 W++P R + +G+G+YG VC AYD ++ VA+KK+ R F+ LI +R RE+ +L Sbjct: 49 WQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNR 108 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-LSDEHVQFLVYQLLR 136 L H++V+ +LD+ P +E F E+Y+V + +D + + L++ H++ L+Y LL Sbjct: 109 LNHDHVVKVLDIVIPK-DVEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNLLV 167 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD-------------------- 176 G+KY+HSAGI+HRDLKP+N VN+DC +++ DFGLAR D Sbjct: 168 GVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNL 227 Query: 177 ----------EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-------- 218 ++TG+V TRWYRAPE++L +Y + +D+WS+GCI AELL Sbjct: 228 VTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAY 287 Query: 219 ---------GKALFP-------GSDYI-------DQLKRIMEVVGTPSPEVLAKISSEHA 255 G + FP G+D+ DQL I ++GTPS E + + E A Sbjct: 288 HADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDA 347 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPE 315 + YI+ P DL+ F ++ AI LL RMLV + ++R++ E LAH +F + E Sbjct: 348 KRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVRIAE 407 Query: 316 DEPEA 320 E A Sbjct: 408 VETNA 412 >3OZ6-A nrPDB Length = 388 Score = 241 bits (616), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 132/372 (35%), Positives = 217/372 (58%), Gaps = 53/372 (14%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 V ++ + ++ +G GAYG V + D R + VAVKK+ FQ+ A+RT+RE+ +L L Sbjct: 7 VLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELS 66 Query: 80 -HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGL 138 HEN++ LL+V ++ +VYLV M DL+ +++ L H Q++VYQL++ + Sbjct: 67 GHENIVNLLNVLRA----DNDRDVYLVFDYMETDLHAVIRANILEPVHKQYVVYQLIKVI 122 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR---------------------QADE 177 KY+HS G++HRD+KPSN+ +N +C +++ DFGL+R D+ Sbjct: 123 KYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDD 182 Query: 178 E---MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKR 234 + +T YVATRWYRAPEI+L Y + +D+WS+GCI+ E+L GK +FPGS ++QL+R Sbjct: 183 DQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLER 242 Query: 235 IMEVVGTPSPEVLAKISSEHARTYIQSLP---PMPQKDLSSIFR-------------GAN 278 I+ V+ PS E + I S A+T I+SL + Q + IF N Sbjct: 243 IIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCN 302 Query: 279 PLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAE-----PYDESVEAKERT 333 A+DLL ++L + ++R+SA +AL H + S +H+P +EP + P +++V + + Sbjct: 303 EEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPINDNV---KHS 359 Query: 334 LEEWKELTYQEV 345 +++++ L Y E+ Sbjct: 360 IDDYRNLVYSEI 371 >3PG1-A nrPDB Length = 362 Score = 230 bits (587), Expect = 7e-61, Method: Compositional matrix adjust. Identities = 123/321 (38%), Positives = 187/321 (58%), Gaps = 26/321 (8%) Query: 28 RPVGSGAYGSVCSAYDA--------RLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 R + SG+YG+VC+ D+ R+ V+ + +R RE+RLL H Sbjct: 28 RFISSGSYGAVCAGVDSEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRLLNHFH 87 Query: 80 HENVIGLLDVFT----PATSIEDFSEVYLVTTLMGADLNNIVKCQ--ALSDEHVQFLVYQ 133 H N++GL D+F PA ++YLVT LM DL ++ Q +S +H+Q+ +Y Sbjct: 88 HPNILGLRDIFVHFEEPA-----MHKLYLVTELMRTDLAQVIHDQRIVISPQHIQYFMYH 142 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ--ADEEMTGYVATRWYRAP 191 +L GL +H AG++HRDL P N+ + ++ ++ I DF LAR+ AD T YV RWYRAP Sbjct: 143 ILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYRAP 202 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 E+++ + + + VD+WS GC+MAE+ KALF GS + +QL +I+EVVGTP E + S Sbjct: 203 ELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMFS 262 Query: 252 SEHARTYIQ-SLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 S AR Y++ SL +P + +++ A+P+A+DL+ +ML + +R+S +AL H YF Sbjct: 263 SPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYFES 322 Query: 311 YHDPEDEPEAEP----YDESV 327 DP D E +DESV Sbjct: 323 LFDPLDLTEGLSERFHFDESV 343 >3NIE-A nrPDB Length = 429 Score = 210 bits (535), Expect = 7e-55, Method: Compositional matrix adjust. Identities = 125/364 (34%), Positives = 187/364 (51%), Gaps = 59/364 (16%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 61 SG +++ + K V +VP + +G G+YG V AYD + VA+KK++R F+ Sbjct: 9 SGRENLYFQGAIIKNV-KVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFED 67 Query: 62 LIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA 121 LI +R RE+ +L LK + +I L D+ P ++ F E+Y+V + +DL + K Sbjct: 68 LIDCKRILREITILNRLKSDYIIRLHDLIIPEDLLK-FDELYIVLEIADSDLKKLFKTPI 126 Query: 122 -LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD---- 176 L+++HV+ ++Y LL G K+IH +GIIHRDLKP+N +N+DC ++I DFGLAR + Sbjct: 127 FLTEQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKD 186 Query: 177 ------------------------EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCI 212 +++T +V TRWYRAPE++L +Y ++DIWS GCI Sbjct: 187 IHIVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCI 246 Query: 213 MAELLQGKA-----------LFPGSDYI-----------------DQLKRIMEVVGTPSP 244 AELL LFPGS DQL I V+GTP Sbjct: 247 FAELLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPE 306 Query: 245 EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 E L I+ + YI+ P DLS + + IDLL ML ++ +R++ +AL+ Sbjct: 307 EDLKCITKQEVIKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALS 366 Query: 305 HAYF 308 H Y Sbjct: 367 HPYL 370 >2I6L-A nrPDB Length = 320 Score = 207 bits (526), Expect = 7e-54, Method: Compositional matrix adjust. Identities = 119/323 (36%), Positives = 193/323 (59%), Gaps = 22/323 (6%) Query: 13 LNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKK--LSRPFQSLIHARRTYR 70 +N +++ R L+P+G G G V SA D ++VA+KK L+ P QS+ HA R Sbjct: 2 MNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDP-QSVKHA---LR 57 Query: 71 ELRLLKHLKHENVIGLLDVFTPATS--------IEDFSEVYLVTTLMGADLNNIVKCQAL 122 E+++++ L H+N++ + ++ P+ S + + + VY+V M DL N+++ L Sbjct: 58 EIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPL 117 Query: 123 SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLARQADEEMT- 180 +EH + +YQLLRGLKYIHSA ++HRDLKP+N+ +N ED L+I DFGLAR D + Sbjct: 118 LEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSH 177 Query: 181 -GYVA----TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRI 235 G+++ T+WYR+P ++L+ +Y + +D+W+ GCI AE+L GK LF G+ ++Q++ I Sbjct: 178 KGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLI 237 Query: 236 MEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQ 295 +E + E ++ S YI++ P K L+ + G + A+D L ++L Sbjct: 238 LESIPVVHEEDRQELLSV-IPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMD 296 Query: 296 RVSAAEALAHAYFSQYHDPEDEP 318 R++A EAL+H Y S Y P DEP Sbjct: 297 RLTAEEALSHPYMSIYSFPMDEP 319 >3N9X-A nrPDB Length = 432 Score = 202 bits (514), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 129/408 (31%), Positives = 197/408 (48%), Gaps = 65/408 (15%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 61 S R Y Q + VP +G G+YG V AYD + VA+KK++R F+ Sbjct: 8 SSGRENLYFQGIKNV--HVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFED 65 Query: 62 LIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA 121 LI +R RE+ +L LK + +I L D+ P ++ F E+Y+V + +DL + K Sbjct: 66 LIDCKRILREITILNRLKSDYIIRLYDLIIPDDLLK-FDELYIVLEIADSDLKKLFKTPI 124 Query: 122 -LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE-- 178 L++EH++ ++Y LL G +IH +GIIHRDLKP+N +N+DC +++ DFGLAR + E Sbjct: 125 FLTEEHIKTILYNLLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKD 184 Query: 179 -----------------------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAE 215 +T +V TRWYRAPE++L +Y +++DIWS GCI AE Sbjct: 185 TNIVNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAE 244 Query: 216 LLQGKA-----------LFPGSDYI-----------------DQLKRIMEVVGTPSPEVL 247 LL LFPGS DQL I ++GTP+ + L Sbjct: 245 LLNMLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDL 304 Query: 248 AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 I+ YI+ P +L + + I+LL ML + ++R++ +AL H Y Sbjct: 305 KNINKPEVIKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPY 364 Query: 308 FSQYHDPEDEPEAE-----PYDESVEAKERTLEEWKELTYQEVLSFKP 350 + E + P+D+ + E L + + +EV SF P Sbjct: 365 LKDVRKKKLENFSTKKIILPFDDWMVLSETQL---RYIFLKEVQSFHP 409 >3NIZ-A nrPDB Length = 311 Score = 186 bits (472), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 111/299 (37%), Positives = 161/299 (53%), Gaps = 14/299 (4%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 ++ Q L VG G YG V A D++ R VA+K++ + RE+ LLK L H Sbjct: 21 EKYQKLEKVGEGTYGVVYKAKDSQGR-IVALKRIRLDAEDEGIPSTAIREISLLKELHHP 79 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV--KCQALSDEHVQFLVYQLLRGLK 139 N++ L+DV + LV M DL ++ L D ++ +YQLLRG+ Sbjct: 80 NIVSLIDVIHSERCLT------LVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGVA 133 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY---VATRWYRAPEIMLN 196 + H I+HRDLKP N+ +N D L++ DFGLAR + Y V T WYRAP++++ Sbjct: 134 HCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMG 193 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHAR 256 Y+ +VDIWS+GCI AE++ GK LFPG DQL +I ++GTP+P ++ E Sbjct: 194 SKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQV-QELPL 252 Query: 257 TYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPE 315 ++ +K SSI G IDLL ML D ++R+SA +A+ H YF DP+ Sbjct: 253 WKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDL-DPQ 310 >2BPM-A nrPDB Length = 309 Score = 185 bits (470), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 109/299 (36%), Positives = 161/299 (53%), Gaps = 14/299 (4%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + Q + +G G YG V A + + VA+KK+ ++ RE+ LLK L H Sbjct: 7 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 66 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSD---EHVQFLVYQLLRGL 138 N++ LLDV I +++YLV + DL + AL+ ++ ++QLL+GL Sbjct: 67 NIVKLLDV------IHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 120 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY---VATRWYRAPEIML 195 + HS ++HRDLKP N+ +N + +++ DFGLAR + Y V T WYRAPEI+L Sbjct: 121 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 180 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 +Y+ VDIWS+GCI AE++ +ALFPG IDQL RI +GTP V ++S Sbjct: 181 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS--M 238 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 314 Y S P ++D S + + LL +ML D ++R+SA ALAH +F P Sbjct: 239 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 297 >1V0B-A nrPDB Length = 288 Score = 181 bits (459), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 110/298 (36%), Positives = 158/298 (53%), Gaps = 22/298 (7%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 ++ GL +G G YG V A + + A+KK+ + T RE+ +LK LKH Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKEDEGIPSTTIREISILKELKHS 60 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK-CQA-LSDEHVQFLVYQLLRGLK 139 N++ L DV I + LV + DL ++ C+ L + + QLL G+ Sbjct: 61 NIVKLYDV------IHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIA 114 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY---VATRWYRAPEIMLN 196 Y H ++HRDLKP N+ +N + EL+I DFGLAR + Y V T WYRAP++++ Sbjct: 115 YCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMG 174 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPS----PEVLAKISS 252 Y+ T+DIWSVGCI AE++ G LFPG DQL RI ++GTP+ P V Sbjct: 175 SKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKY 234 Query: 253 EHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + T + LP S +G + IDLL +ML LD +QR++A +AL HAYF + Sbjct: 235 DPNFTVYEPLP------WESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >1UA2-A nrPDB Length = 346 Score = 181 bits (458), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 109/301 (36%), Positives = 160/301 (53%), Gaps = 17/301 (5%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH---ARRTYRELRLLKHL 78 +R + L +G G + +V A D Q VA+KK+ +S R RE++LL+ L Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQAL--SDEHVQFLVYQLLR 136 H N+IGLLD F ++I LV M DL I+K +L + H++ + L+ Sbjct: 70 SHPNIIGLLDAFGHKSNIS------LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY---VATRWYRAPEI 193 GL+Y+H I+HRDLKP+N+ ++E+ L++ DFGLA+ Y V TRWYRAPE+ Sbjct: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSE 253 + Y VD+W+VGCI+AELL PG +DQL RI E +GTP+ E + S Sbjct: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 Query: 254 HARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHD 313 +S P +P L IF A +DL+ + + + R++A +AL YFS Sbjct: 244 PDYVTFKSFPGIP---LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 Query: 314 P 314 P Sbjct: 301 P 301 >4AU8-A nrPDB Length = 296 Score = 172 bits (436), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 108/303 (35%), Positives = 157/303 (51%), Gaps = 22/303 (7%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 Q+ + L +G G YG+V A + + VA+K++ RE+ LLK LKH+ Sbjct: 6 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 65 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV-KCQA-LSDEHVQFLVYQLLRGLK 139 N++ L DV + ++ LV DL C L E V+ ++QLL+GL Sbjct: 66 NIVRLHDV------LHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 119 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY---VATRWYRAPEIMLN 196 + HS ++HRDLKP N+ +N + EL++ DFGLAR + Y V T WYR P+++ Sbjct: 120 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 179 Query: 197 WMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 Y+ ++D+WS GCI AEL G+ LFPG+D DQLKRI ++GTP+ E + Sbjct: 180 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM----- 234 Query: 256 RTYIQSLPPMPQ----KDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 T + P P L ++ N DLL +L + QR+SA EAL H YFS + Sbjct: 235 -TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 293 Query: 312 HDP 314 P Sbjct: 294 CPP 296 >3EB0-A nrPDB Length = 383 Score = 171 bits (433), Expect = 5e-43, Method: Compositional matrix adjust. Identities = 103/324 (31%), Positives = 165/324 (50%), Gaps = 50/324 (15%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 + +G+G++G VC +D ++ A+KK+ L R REL ++K L H N+I L+ Sbjct: 13 KTLGTGSFGIVCEVFDIESGKRFALKKV------LQDPRYKNRELDIMKVLDHVNIIKLV 66 Query: 88 DVF--------TPATSIEDFSEV-----------------------------YLVTTLMG 110 D F P +D +++ Y+ TL Sbjct: 67 DYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDTLHK 126 Query: 111 ADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDF 169 + I +++ + +YQL R + +IHS GI HRD+KP N+ VN +D L++ DF Sbjct: 127 VLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDF 186 Query: 170 GLARQ--ADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD 227 G A++ E Y+ +R+YRAPE+ML Y ++D+WS+GC+ EL+ GK LF G Sbjct: 187 GSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFSGET 246 Query: 228 YIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANP-LAIDLLG 286 IDQL RI++++GTP+ E + +++ + P + KD I P LAIDLL Sbjct: 247 SIDQLVRIIQIMGTPTKEQMIRMNPHYTEV---RFPTLKAKDWRKILPEGTPSLAIDLLE 303 Query: 287 RMLVLDSDQRVSAAEALAHAYFSQ 310 ++L + D R++ EA+AH +F Sbjct: 304 QILRYEPDLRINPYEAMAHPFFDH 327 >6GU6-A nrPDB Length = 302 Score = 170 bits (430), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 102/290 (35%), Positives = 155/290 (53%), Gaps = 15/290 (5%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 + +G G YG V Q VA+KK+ + RE+ LLK L+H N++ L Sbjct: 12 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 71 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGADL----NNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 DV ++D S +YL+ + DL ++I Q + V+ +YQ+L+G+ + H Sbjct: 72 QDVL-----MQD-SRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 125 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY---VATRWYRAPEIMLNWMH 199 S ++HRDLKP N+ +++ +++ DFGLAR + Y V T WYR+PE++L Sbjct: 126 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 185 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI 259 Y+ VDIWS+G I AEL K LF G IDQL RI +GTP+ EV ++ E + Y Sbjct: 186 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV--ESLQDYK 243 Query: 260 QSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 + P L+S + + +DLL +ML+ D +R+S AL H YF+ Sbjct: 244 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 293 >4E7W-A nrPDB Length = 394 Score = 170 bits (430), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 106/292 (36%), Positives = 164/292 (56%), Gaps = 23/292 (7%) Query: 30 VGSGAYGSVCSAYDARLRQ--KVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 +G+G++G V + A+L + +VA+KK+ L R REL++++ +KH NV+ L Sbjct: 48 IGNGSFGVV---FQAKLVESDEVAIKKV------LQDKRFKNRELQIMRIVKHPNVVDLK 98 Query: 88 DVFTPATSIED--FSEV---YLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 F +D F + Y+ T+ A + Q + ++ +YQLLR L YIH Sbjct: 99 AFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIH 158 Query: 143 SAGIIHRDLKPSNVAVNEDCE-LRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWMH 199 S GI HRD+KP N+ ++ L+++DFG A+ A E Y+ +R+YRAPE++ + Sbjct: 159 SIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIFGATN 218 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI 259 Y +DIWS GC+MAEL+QG+ LFPG IDQL I++V+GTPS E + ++ + Sbjct: 219 YTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHKF 278 Query: 260 QSLPPMPQKDLSSIFRGANPL-AIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + P P S +FR P AIDL+ R+L R++A EAL H +F + Sbjct: 279 PQIRPHP---FSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDE 327 >4KRC-A nrPDB Length = 317 Score = 165 bits (418), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 100/306 (32%), Positives = 167/306 (54%), Gaps = 26/306 (8%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 + + L +G+G Y +V + VA+K++ + + RE+ L+K LKHEN Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST-AIREISLMKELKHEN 64 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSD-------EHVQFLVYQLL 135 ++ L DV I +++ LV M DL + + + + V++ +QLL Sbjct: 65 IVRLYDV------IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD---EEMTGYVATRWYRAPE 192 +GL + H I+HRDLKP N+ +N+ +L++ DFGLAR + V T WYRAP+ Sbjct: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 +++ Y+ ++DIWS GCI+AE++ GK LFPG++ +QLK I +++GTP+ + ++ Sbjct: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 Query: 253 -EHARTYIQSLPPMPQKDLSSIFR--GANPL---AIDLLGRMLVLDSDQRVSAAEALAHA 306 IQ PP +DL + + PL +D L +L L+ D R+SA +AL H Sbjct: 239 LPKYNPNIQQRPP---RDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 Query: 307 YFSQYH 312 +F++Y+ Sbjct: 296 WFAEYY 301 >5AIR-A nrPDB Length = 430 Score = 164 bits (414), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 97/295 (32%), Positives = 158/295 (53%), Gaps = 18/295 (6%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G+G++G V A + VA+KK+ L R REL++++ L H N++ L Sbjct: 72 IGNGSFGVVYQAKLCDSGELVAIKKV------LQDKRFKNRELQIMRKLDHCNIVRLRYF 125 Query: 90 FTPATSIEDFSEVYLVTTLMGADLNNIVK-----CQALSDEHVQFLVYQLLRGLKYIHSA 144 F + +D + LV + + + + Q L +V+ +YQL R L YIHS Sbjct: 126 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 185 Query: 145 GIIHRDLKPSNVAVNEDCE-LRILDFGLARQA--DEEMTGYVATRWYRAPEIMLNWMHYN 201 GI HRD+KP N+ ++ D L++ DFG A+Q E Y+ +R+YRAPE++ Y Sbjct: 186 GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYT 245 Query: 202 QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQS 261 ++D+WS GC++AELL G+ +FPG +DQL I++V+GTP+ E + +++ + Sbjct: 246 SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF---K 302 Query: 262 LPPMPQKDLSSIFRGANPL-AIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPE 315 P + + +FR P AI L R+L R++ EA AH++F + DP Sbjct: 303 FPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN 357 >1G3N-A nrPDB Length = 326 Score = 157 bits (396), Expect = 9e-39, Method: Compositional matrix adjust. Identities = 105/297 (35%), Positives = 168/297 (56%), Gaps = 17/297 (5%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQK-VAVKKLSRPFQSLIHARRTYRELRLLKHLK- 79 Q+ + + +G GAYG V A D + + VA+K++ T RE+ +L+HL+ Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 80 --HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLN---NIVKCQALSDEHVQFLVYQL 134 H NV+ L DV T + + + +++ LV + DL + V + E ++ +++QL Sbjct: 71 FEHPNVVRLFDVCTVSRTDRE-TKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 135 LRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM--TGYVATRWYRAPE 192 LRGL ++HS ++HRDLKP N+ V ++++ DFGLAR +M T V T WYRAPE Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK-IS 251 ++L Y VD+WSVGCI AE+ + K LF GS +DQL +I++V+G P E + ++ Sbjct: 190 VLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 + +S P+ +K ++ I + L DLL + L + +R+SA AL+H YF Sbjct: 249 LPRQAFHSKSAQPI-EKFVTDI----DELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 >5G6V-A nrPDB Length = 324 Score = 156 bits (395), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 100/288 (34%), Positives = 147/288 (51%), Gaps = 15/288 (5%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 L +G G Y +V VA+K++ + RE+ LLK LKH N++ L Sbjct: 7 LDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCT-AIREVSLLKDLKHANIVTL 65 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGADLNNIVK-CQALSDEH-VQFLVYQLLRGLKYIHSA 144 D+ S+ LV + DL + C + + H V+ ++QLLRGL Y H Sbjct: 66 HDIIHTEKSLT------LVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQ 119 Query: 145 GIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY---VATRWYRAPEIMLNWMHYN 201 ++HRDLKP N+ +NE EL++ DFGLAR Y V T WYR P+I+L Y+ Sbjct: 120 KVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDYS 179 Query: 202 QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI-SSEHARTYIQ 260 +D+W VGCI E+ G+ LFPGS +QL I ++GTP+ E I S+E +TY Sbjct: 180 TQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTY-- 237 Query: 261 SLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 + P + L S + DLL ++L + R+SA +A+ H +F Sbjct: 238 NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >5Y86-A nrPDB Length = 588 Score = 155 bits (392), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 110/350 (31%), Positives = 177/350 (50%), Gaps = 47/350 (13%) Query: 1 MSGPRAGFYRQELNKTVWEVPQ-----RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKL 55 + GP G Y + + VP+ R + L+ +G G++G V YD +LRQ VA+K + Sbjct: 182 IGGPNNGGY-DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV 240 Query: 56 SRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNN 115 + H R+ E+R+L+HLK ++ G ++V S + V + L+ DL Sbjct: 241 RN--EKRFH-RQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYE 297 Query: 116 IVK---CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED--CELRILDFG 170 ++K Q S + V+ +L+ L +H IIH DLKP N+ + +++DFG Sbjct: 298 LIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG 357 Query: 171 LARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID 230 + +++ Y+ +R+YRAPEI+L Y+ +DIWS GCI+AELL G+ LFPG D D Sbjct: 358 SSCFEYQKLYTYIQSRFYRAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD 416 Query: 231 QLKRIMEVVGTPSPEVLAKISSEHARTYIQS--LP------------------------- 263 QL +ME++G P P++L + S+ A+ +I S +P Sbjct: 417 QLACMMELLGMPPPKLLEQ--SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK 474 Query: 264 --PMPQKDLSSIFRGANP-LAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 P KD + +G + L I+ L R L D R++ A+AL H + S+ Sbjct: 475 RGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISK 524 >4BBM-A nrPDB Length = 331 Score = 154 bits (388), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 93/293 (31%), Positives = 154/293 (52%), Gaps = 13/293 (4%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 ++ + L VG G+YG V + + VA+KK + + RE++LLK L+HE Sbjct: 25 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHE 84 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC--QALSDEHVQFLVYQLLRGLK 139 N++ LL+V YLV + + + ++ L + VQ ++Q++ G+ Sbjct: 85 NLVNLLEVCKKK------KRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIG 138 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYRAPEIMLN 196 + HS IIHRD+KP N+ V++ +++ DFG AR E VATRWYRAPE+++ Sbjct: 139 FCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVG 198 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHAR 256 + Y + VD+W++GC++ E+ G+ LFPG IDQL IM +G P + Sbjct: 199 DVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVF 258 Query: 257 TYIQSLPPMPQKD-LSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 ++ LP + +++ L + + + IDL + L +D D+R AE L H +F Sbjct: 259 AGVR-LPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF 310 >3ZDU-A nrPDB Length = 325 Score = 152 bits (385), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 99/291 (34%), Positives = 151/291 (51%), Gaps = 12/291 (4%) Query: 25 QGLRPVGSGAYGSVCSAYDARLRQKVAVKKL-SRPFQSLIHARRTYRELRLLKHLKHENV 83 + L VG G+YG+V Q VA+K RP QS+ + RE++ LK HEN+ Sbjct: 6 ETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSV--NKIAMREIKFLKQFHHENL 63 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHS 143 + L++VF I E T L +L + C L + ++ ++Q+LR + Y+HS Sbjct: 64 VNLIEVFRQKKKIHLVFEFIDHTVL--DELQHY--CHGLESKRLRKYLFQILRAIDYLHS 119 Query: 144 AGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY---VATRWYRAPEIMLNWMHY 200 IIHRD+KP N+ V++ ++ DFG AR Y VATRWYRAPE++L Y Sbjct: 120 NNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSY 179 Query: 201 NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQ 260 + VDIW++GC++ E+ G P S +D L +I+ VG SP L I S+ Sbjct: 180 GKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPH-LQNIFSKSPIFAGV 238 Query: 261 SLPPMPQ-KDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 LP + K+ + N L D++ L +D R+S+++ L H YF++ Sbjct: 239 VLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTR 289 >4NST-A nrPDB Length = 351 Score = 152 bits (384), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 91/291 (31%), Positives = 146/291 (50%), Gaps = 15/291 (5%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G G YG V A D + VA+KK+ + RE+++L+ L H +V+ + ++ Sbjct: 21 IGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEI 80 Query: 90 FTPATSIEDFSE----VYLVTTLMGADLNNIVKCQAL--SDEHVQFLVYQLLRGLKYIHS 143 T DF + YLV M DL +++ + S++H++ + QL+ GL+Y H Sbjct: 81 VTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHK 140 Query: 144 AGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE----MTGYVATRWYRAPEIMLNWMH 199 +HRD+K SN+ +N ++++ DFGLAR + E T V T WYR PE++L Sbjct: 141 KNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEER 200 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI 259 Y +D+WS GCI+ EL K +F + + QL+ I + G+P P V + Y Sbjct: 201 YTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIK---LPYF 257 Query: 260 QSLPPMPQ--KDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 ++ P Q + L F A+DLL ML LD +R +A + L + Sbjct: 258 NTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL 308 >5EFQ-A nrPDB Length = 347 Score = 151 bits (381), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 90/291 (30%), Positives = 144/291 (49%), Gaps = 15/291 (5%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G G YG V A D + VA+KK+ + RE+++L+ L H+++I + ++ Sbjct: 19 IGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEI 78 Query: 90 FTPATSIEDFSE----VYLVTTLMGADLNNIVKCQAL--SDEHVQFLVYQLLRGLKYIHS 143 T DF + YLV M DL +++ + ++ H++ + QL+ GL Y H Sbjct: 79 VTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHK 138 Query: 144 AGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE----MTGYVATRWYRAPEIMLNWMH 199 +HRD+K SN+ +N ++++ DFGLAR E T V T WYR PE++L Sbjct: 139 KNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEER 198 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI 259 Y +D+WS GCI+ EL K +F + + QL+ I + G+P P V + Y Sbjct: 199 YTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIK---LPYF 255 Query: 260 QSLPPMPQ--KDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 ++ P Q + L F A+DL ML LD +R +A +AL + Sbjct: 256 NTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFL 306 >4BGQ-A nrPDB Length = 304 Score = 150 bits (380), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 97/301 (32%), Positives = 152/301 (50%), Gaps = 16/301 (5%) Query: 16 TVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLL 75 + V + + L VG GAYG V + VA+KK ++ T REL++L Sbjct: 6 NIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKML 65 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--CQALSDEHVQFLVYQ 133 + LK EN++ L + F ++YLV + ++ +++ + E V+ +YQ Sbjct: 66 RTLKQENIVELKEAFRRR------GKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQ 119 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY----VATRWYR 189 L++ + + H I+HRD+KP N+ ++ + L++ DFG AR E VATRWYR Sbjct: 120 LIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYR 179 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249 +PE++L Y ++VD+WSVGCI+ EL G+ LFPG IDQL I +V+G P P K Sbjct: 180 SPELLLG-APYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLG-PLPSEQMK 237 Query: 250 ISSEHARTYIQSLPPM--PQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 + + R + P + PQ N + +DL+ +L LD R + L H Sbjct: 238 LFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPT 297 Query: 308 F 308 F Sbjct: 298 F 298 >3GC0-A nrPDB Length = 329 Score = 150 bits (378), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 105/299 (35%), Positives = 150/299 (50%), Gaps = 20/299 (6%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 R + + +G G YG V A D + VA+K++ + RE+ LLK L+H N Sbjct: 35 RYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHRN 94 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV-KCQALSDEHVQFLVYQLLRGLKYI 141 +I L V I ++L+ DL + K +S ++ +YQL+ G+ + Sbjct: 95 IIELKSV------IHHNHRLHLIFEYAENDLKKYMDKNPDVSMRVIKSFLYQLINGVNFC 148 Query: 142 HSAGIIHRDLKPSNV--AVNEDCE---LRILDFGLARQAD---EEMTGYVATRWYRAPEI 193 HS +HRDLKP N+ +V++ E L+I DFGLAR + T + T WYR PEI Sbjct: 149 HSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEI 208 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSE 253 +L HY+ +VDIWS+ CI AE+L LFPG IDQL +I EV+G P +++ Sbjct: 209 LLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTA- 267 Query: 254 HARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGR--MLVLDSDQRVSAAEALAHAYFSQ 310 + QS P K L + GA L ML +D +R+SA AL H YFS Sbjct: 268 -LPDWKQSFPKFRGKTLKRVL-GALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFSH 324 >2W96-B nrPDB Length = 306 Score = 148 bits (373), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 108/306 (35%), Positives = 154/306 (50%), Gaps = 19/306 (6%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK--- 79 R + + +G GAYG+V A D VA+K + P T RE+ LL+ L+ Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFE 64 Query: 80 HENVIGLLDVFTPATSIEDFS-EVYLVTTLMGADLNNIVKCQ---ALSDEHVQFLVYQLL 135 H NV+ L+DV ATS D +V LV + DL + L E ++ L+ Q L Sbjct: 65 HPNVVRLMDVC--ATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 122 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT--GYVATRWYRAPEI 193 RGL ++H+ I+HRDLKP N+ V +++ DFGLAR +M V T WYRAPE+ Sbjct: 123 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEV 182 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSE 253 +L Y VD+WSVGCI AE+ + K LF G+ DQL +I +++G P + + S Sbjct: 183 LLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 241 Query: 254 HARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHD 313 + PP + + S+ LL ML + +R+SA AL H+Y H Sbjct: 242 PRGAF----PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL---HK 294 Query: 314 PEDEPE 319 E PE Sbjct: 295 DEGNPE 300 >4AGU-A nrPDB Length = 311 Score = 147 bits (372), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 92/299 (30%), Positives = 147/299 (49%), Gaps = 9/299 (3%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 ++ + + +G G+YG V + Q VA+KK + + RE+R+LK LKH Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEH-VQFLVYQLLRGLKY 140 N++ LL+VF + E T L D + Q EH V+ + +Q L+ + + Sbjct: 63 NLVNLLEVFRRKRRLHLVFEYCDHTVLHELD-----RYQRGVPEHLVKSITWQTLQAVNF 117 Query: 141 IHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY---VATRWYRAPEIMLNW 197 H IHRD+KP N+ + + +++ DFG AR Y VATRWYR+PE+++ Sbjct: 118 CHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGD 177 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257 Y VD+W++GC+ AELL G L+PG +DQL I + +G P S+ + Sbjct: 178 TQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFS 237 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPED 316 ++ P + L F + A+ LL L +D +R++ + L H YF + ED Sbjct: 238 GVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIREIED 296 >3MIA-A nrPDB Length = 351 Score = 147 bits (371), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 98/308 (31%), Positives = 159/308 (51%), Gaps = 22/308 (7%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 + + L +G G +G V A + QKVA+KK+ + RE+++L+ LKHEN Sbjct: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 Query: 83 VIGLLDVFTPATSIEDFSE--VYLVTTLMGADL----NNIVKCQALSDEHVQFLVYQLLR 136 V+ L+++ S + + +YLV DL +N++ LS+ ++ ++ LL Sbjct: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRVMQMLLN 135 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD-------EEMTGYVATRWYR 189 GL YIH I+HRD+K +NV + D L++ DFGLAR T V T WYR Sbjct: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249 PE++L Y +D+W GCIMAE+ + G+ QL I ++ G+ +PEV Sbjct: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 Query: 250 ISSEHARTYIQSLPPMPQK---DLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHA 306 + + ++ + +K L + R +P A+DL+ ++LVLD QR+ + +AL H Sbjct: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVR--DPYALDLIDKLLVLDPAQRIDSDDALNHD 313 Query: 307 YFSQYHDP 314 +F + DP Sbjct: 314 FF--WSDP 319 >3E3P-A nrPDB Length = 360 Score = 147 bits (370), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 102/309 (33%), Positives = 155/309 (50%), Gaps = 25/309 (8%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL---K 79 R Q R G G +G+V + VA+KK+ + R REL++++ L Sbjct: 24 RFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKV------IQDPRFRNRELQIMQDLAVLH 77 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVT-------TLMGADLNNIVKCQALSDEHVQFLVY 132 H N++ L F D ++YL TL N + A ++ ++ Sbjct: 78 HPNIVQLQSYFY-TLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLF 136 Query: 133 QLLRGLKYIH--SAGIIHRDLKPSNVAVNE-DCELRILDFGLARQ--ADEEMTGYVATRW 187 QL+R + +H S + HRD+KP NV VNE D L++ DFG A++ E Y+ +R+ Sbjct: 137 QLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRY 196 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 247 YRAPE++ HY VDIWSVGCI AE++ G+ +F G + QL I+ V+G PS EVL Sbjct: 197 YRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVL 256 Query: 248 AKISSEHARTYIQSLPPMPQKDLSS--IFRGANPLAIDLLGRMLVLDSDQRVSAAEALAH 305 K++ H + + +P ++ S + A A DLL +L ++R+ EAL H Sbjct: 257 RKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKE-AYDLLSALLQYLPEERMKPYEALCH 315 Query: 306 AYFSQYHDP 314 YF + HDP Sbjct: 316 PYFDELHDP 324 >6O6Q-A nrPDB Length = 335 Score = 136 bits (342), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 94/311 (30%), Positives = 160/311 (51%), Gaps = 40/311 (12%) Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77 W + + LR +G G Y V D R+KV +K L +P + ++ RE+ +LK+ Sbjct: 37 WNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVL-KP----VKRKKIKREISILKN 91 Query: 78 L-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNI---VKCQALSDEHVQFLVYQ 133 L N+I +LDV S L+ +NNI +D ++F +Y+ Sbjct: 92 LVDGPNIIAMLDVVREPQS--------KTPGLIFEHINNIDFRSLYPTFTDYDIRFYMYE 143 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCE-LRILDFGLAR--QADEEMTGYVATRWYRA 190 LL+ L Y HS GI+HRD+KP NV ++ D + LR++D+GLA E VA+R+++ Sbjct: 144 LLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKG 203 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLQGKA-LFPGSDYIDQLKRIMEVVGTPS------ 243 PE+++++ Y+ ++D+WS GC++A ++ K F G DQL +I+ V+G+ + Sbjct: 204 PELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLE 263 Query: 244 ------PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV 297 E I + R +++ + + +S F +DL+ R+L D +R+ Sbjct: 264 KYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEF-------LDLIDRLLRYDHQERL 316 Query: 298 SAAEALAHAYF 308 +A EA+ HAYF Sbjct: 317 TAKEAMKHAYF 327 >5ZTN-A nrPDB Length = 429 Score = 135 bits (341), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 101/353 (28%), Positives = 172/353 (48%), Gaps = 59/353 (16%) Query: 2 SGPRAGFYRQELNKTVWEVPQ-----RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLS 56 GP G Y + V +VP R + L+ +G G++G V AYD ++ Q VA+K + Sbjct: 73 GGPNNGGYDDDQGSYV-QVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVR 131 Query: 57 RPFQSLIHARRTYRELRLLKHLKHE------NVIGLLDVFTPATSIEDFSEVYLVTTLMG 110 + H R+ E+R+L+HL+ + NVI +L+ FT I + L+ Sbjct: 132 N--EKRFH-RQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHI------CMTFELLS 182 Query: 111 ADLNNIVK---CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE--LR 165 +L ++K Q S V+ + +L+ L +H IIH DLKP N+ + + ++ Sbjct: 183 MNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIK 242 Query: 166 ILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG 225 ++DFG + + + Y+ +R+YRAPE++L Y +D+WS+GCI+AELL G L PG Sbjct: 243 VIDFGSSCYEHQRVYTYIQSRFYRAPEVILG-ARYGMPIDMWSLGCILAELLTGYPLLPG 301 Query: 226 SDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQS------------------------ 261 D DQL ++E++G PS ++L +S+ A+ ++ S Sbjct: 302 EDEGDQLACMIELLGMPSQKLLD--ASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRS 359 Query: 262 -----LPPMPQKDLSSIFRGA-NPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 P ++ + +G +PL +D L + L D R++ +AL H + Sbjct: 360 RRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 412 >5XVU-A nrPDB Length = 332 Score = 134 bits (337), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 92/308 (29%), Positives = 159/308 (51%), Gaps = 29/308 (9%) Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77 W P R + ++ +G G Y V + YD + A+K L + I +L++ Sbjct: 27 WNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKVLKPVKKKKIKREIK-----ILQN 81 Query: 78 LKH-ENVIGLLDVFT-PATSIEDFSEVYLVTTLMGADLNNI---VKCQALSDEHVQFLVY 132 L N+I LLD+ P T +L+ +NNI +D+ +++ +Y Sbjct: 82 LNGGPNIIKLLDIVKDPVTK---------TPSLIFEYINNIDFKTLYPKFTDKDIRYYIY 132 Query: 133 QLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLAR--QADEEMTGYVATRWYR 189 Q+L+ L Y HS GI+HRD+KP N+ ++ E+ ++R++ +GLA +E VA+R+Y+ Sbjct: 133 QILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRYYK 192 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLQGKA-LFPGSDYIDQLKRIMEVVGTPSPEV-L 247 PE++++ Y+ ++DIWS+GC++A ++ K F G D DQL +I +V+GT L Sbjct: 193 GPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYL 252 Query: 248 AKISSEHARTYIQSLPPMPQKDLSSIFRGAN-----PLAIDLLGRMLVLDSDQRVSAAEA 302 K + + Y+ L +K S +N IDL+ +ML+ D +R++ EA Sbjct: 253 KKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEA 312 Query: 303 LAHAYFSQ 310 + H YF + Sbjct: 313 MEHPYFRE 320 >6HMD-A nrPDB Length = 365 Score = 128 bits (322), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 84/267 (31%), Positives = 140/267 (52%), Gaps = 49/267 (18%) Query: 82 NVIGLLDVF------TPATSIE-----DFSEVYLVTTLMGADLNNIVKCQALSDEHVQFL 130 N+I L+D TPA E DF ++Y Q L+D ++F Sbjct: 109 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY----------------QILTDFDIRFY 152 Query: 131 VYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLAR--QADEEMTGYVATRW 187 +Y+LL+ L Y HS GI+HRD+KP NV ++ + +LR++D+GLA +E VA+R+ Sbjct: 153 MYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY 212 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELL-QGKALFPGSDYIDQLKRIMEVVGTPSPEV 246 ++ PE+++++ Y+ ++D+WS+GC++A ++ + + F G D DQL RI +V+GT Sbjct: 213 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYG 272 Query: 247 LAK------------ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSD 294 K I +H+R ++ + L S P A+DLL ++L D Sbjct: 273 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVS------PEALDLLDKLLRYDHQ 326 Query: 295 QRVSAAEALAHAYFSQYHDPEDEPEAE 321 QR++A EA+ H YF + +P A+ Sbjct: 327 QRLTAKEAMEHPYFYPVVKEQSQPSAD 353 >3NCG-A nrPDB Length = 486 Score = 124 bits (312), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 84/289 (29%), Positives = 139/289 (48%), Gaps = 42/289 (14%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G G++G V D +Q+ AVK +++ RE+ LLK L H N++ L ++ Sbjct: 30 LGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLFEI 89 Query: 90 FTPATSIEDFSEVYLVTTL-MGADL-NNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 +ED S Y+V L G +L + I+K + S+ ++ Q+ G+ Y+H I+ Sbjct: 90 ------LEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIV 143 Query: 148 HRDLKPSNVAVN---EDCELRILDFGLAR--QADEEMTGYVATRWYRAPEIMLNWMHYNQ 202 HRDLKP N+ + +DC+++I+DFGL+ Q + +M + T +Y APE++ Y++ Sbjct: 144 HRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG--TYDE 201 Query: 203 TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSL 262 D+WS G I+ LL G F G + D LKR+ Y L Sbjct: 202 KCDVWSAGVILYILLSGTPPFYGKNEYDILKRV------------------ETGKYAFDL 243 Query: 263 PPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 P +R + A DL+ +ML R++A + L H + +Y Sbjct: 244 PQ---------WRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKY 283 >6EII-A nrPDB Length = 352 Score = 124 bits (312), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 80/248 (32%), Positives = 131/248 (52%), Gaps = 37/248 (14%) Query: 82 NVIGLLDVF------TPATSIE-----DFSEVYLVTTLMGADLNNIVKCQALSDEHVQFL 130 N+I L D+ TPA E DF ++Y Q L+D ++F Sbjct: 116 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY----------------QTLTDYDIRFY 159 Query: 131 VYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLAR--QADEEMTGYVATRW 187 +Y++L+ L Y HS GI+HRD+KP NV ++ E +LR++D+GLA +E VA+R+ Sbjct: 160 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY 219 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKA-LFPGSDYIDQLKRIMEVVGTPS-PE 245 ++ PE+++++ Y+ ++D+WS+GC++A ++ K F G D DQL RI +V+GT + Sbjct: 220 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 279 Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGAN-----PLAIDLLGRMLVLDSDQRVSAA 300 + K + E + L +K N P A+D L ++L D R++A Sbjct: 280 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 339 Query: 301 EALAHAYF 308 EA+ H YF Sbjct: 340 EAMEHPYF 347 >3DFA-A nrPDB Length = 286 Score = 124 bits (311), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 83/289 (28%), Positives = 137/289 (47%), Gaps = 42/289 (14%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G G++G V D +Q+ AVK +++ RE+ LLK L H N++ L ++ Sbjct: 30 LGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLFEI 89 Query: 90 FTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 +ED S Y+V L G + I+K + S+ ++ Q+ G+ Y+H I+ Sbjct: 90 ------LEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIV 143 Query: 148 HRDLKPSNVAV---NEDCELRILDFGLAR--QADEEMTGYVATRWYRAPEIMLNWMHYNQ 202 HRDLKP N+ + +DC+++I+DFGL+ Q + +M + T +Y APE++ Y++ Sbjct: 144 HRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG--TYDE 201 Query: 203 TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSL 262 D+WS G I+ LL G F G + D LKR+ Y L Sbjct: 202 KCDVWSAGVILYILLSGTPPFYGKNEYDILKRV------------------ETGKYAFDL 243 Query: 263 PPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 P +R + A DL+ +ML R++A + L H + +Y Sbjct: 244 PQ---------WRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKY 283 >4MD7-E nrPDB Length = 391 Score = 123 bits (308), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 79/248 (31%), Positives = 132/248 (53%), Gaps = 37/248 (14%) Query: 82 NVIGLLDVF------TPATSIE-----DFSEVYLVTTLMGADLNNIVKCQALSDEHVQFL 130 N+I L D+ TPA E DF ++Y Q L+D ++F Sbjct: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY----------------QTLTDYDIRFY 136 Query: 131 VYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLAR--QADEEMTGYVATRW 187 +Y++L+ L Y HS GI+HRD+KP NV ++ E +LR++D+GLA +E VA+R+ Sbjct: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY 196 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELL-QGKALFPGSDYIDQLKRIMEVVGTPS-PE 245 ++ PE+++++ Y+ ++D+WS+GC++A ++ + + F G D DQL RI +V+GT + Sbjct: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256 Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGAN-----PLAIDLLGRMLVLDSDQRVSAA 300 + K + E + L +K N P A+D L ++L D R++A Sbjct: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316 Query: 301 EALAHAYF 308 EA+ H YF Sbjct: 317 EAMEHPYF 324 >4CRL-A nrPDB Length = 406 Score = 121 bits (304), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 48/318 (15%) Query: 30 VGSGAYGSV--CSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 VG G YG V D + + A+K++ S+ RE+ LL+ LKH NVI L Sbjct: 30 VGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISM----SACREIALLRELKHPNVISLQ 85 Query: 88 DVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEH----------VQFLVYQLLRG 137 VF +V+L+ DL +I+K S + V+ L+YQ+L G Sbjct: 86 KVFLSHAD----RKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDG 141 Query: 138 LKYIHSAGIIHRDLKPSNVAVN----EDCELRILDFGLARQADE------EMTGYVATRW 187 + Y+H+ ++HRDLKP+N+ V E ++I D G AR + ++ V T W Sbjct: 142 IHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFW 201 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD---------YIDQLKRIMEV 238 YRAPE++L HY + +DIW++GCI AELL + +F + DQL RI V Sbjct: 202 YRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNV 261 Query: 239 VGTPSPEVLAKISS--EHARTYIQSLPPMPQKDLSSIFR------GANPLAIDLLGRMLV 290 +G P+ + I EH+ T ++ + S I + A LL ++L Sbjct: 262 MGFPADKDWEDIKKMPEHS-TLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLT 320 Query: 291 LDSDQRVSAAEALAHAYF 308 +D +R+++ +A+ YF Sbjct: 321 MDPIKRITSEQAMQDPYF 338 >3MA6-A nrPDB Length = 298 Score = 120 bits (300), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 89/297 (29%), Positives = 145/297 (48%), Gaps = 43/297 (14%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLS-RPFQSLIHARRTYRELRLLKHLKHE 81 R +G R +G G++G V D Q+ AVK +S R + RE++LLK L H Sbjct: 33 RYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHP 92 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLK 139 N++ L + F ED YLV + G + I+ + S+ ++ Q+L G+ Sbjct: 93 NIMKLYEFF------EDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGIT 146 Query: 140 YIHSAGIIHRDLKPSNVAV---NEDCELRILDFGLAR--QADEEMTGYVATRWYRAPEIM 194 Y+H I+HRDLKP N+ + ++D +RI+DFGL+ +A ++M + T +Y APE++ Sbjct: 147 YMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVL 206 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH 254 Y++ D+WS G I+ LL G F G++ D LK++ + K + E Sbjct: 207 HG--TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEK----------GKYTFE- 253 Query: 255 ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 +PQ ++ + A DL+ +ML R+SA +AL H + Y Sbjct: 254 ----------LPQ------WKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTY 294 >2PVN-A nrPDB Length = 352 Score = 119 bits (298), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 76/249 (30%), Positives = 133/249 (53%), Gaps = 35/249 (14%) Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNI---VKCQALSDEHVQFLVYQLLRGL 138 N++ LLD+ S +L+ +NN V L+D +++ +Y+LL+ L Sbjct: 108 NIVKLLDIVRDQHSK--------TPSLIFEYVNNTDFKVLYPTLTDYDIRYYIYELLKAL 159 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDC-ELRILDFGLAR--QADEEMTGYVATRWYRAPEIML 195 Y HS GI+HRD+KP NV ++ + +LR++D+GLA +E VA+R+++ PE+++ Sbjct: 160 DYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLV 219 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKA-LFPGSDYIDQLKRIMEVVGTPS----------- 243 + Y+ ++D+WS+GC+ A ++ K F G D DQL +I +V+GT Sbjct: 220 DLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIE 279 Query: 244 --PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAE 301 P++ A + + +++ + Q +S P AID L ++L D +R++A E Sbjct: 280 LDPQLEALVGRHSRKPWLKFMNADNQHLVS-------PEAIDFLDKLLRYDHQERLTALE 332 Query: 302 ALAHAYFSQ 310 A+ H YF Q Sbjct: 333 AMTHPYFQQ 341 >5JN2-A nrPDB Length = 525 Score = 119 bits (298), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 89/297 (29%), Positives = 143/297 (48%), Gaps = 43/297 (14%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLS-RPFQSLIHARRTYRELRLLKHLKHE 81 R +G R +G G++G V D Q+ AVK +S R + RE++LLK L H Sbjct: 68 RYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHP 127 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTL-MGADL-NNIVKCQALSDEHVQFLVYQLLRGLK 139 N++ L + F ED YLV + G +L + I+ + S+ ++ Q+L G+ Sbjct: 128 NIMKLYEFF------EDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGIT 181 Query: 140 YIHSAGIIHRDLKPSNVAV---NEDCELRILDFGLAR--QADEEMTGYVATRWYRAPEIM 194 Y+H I+HRDLKP N+ + ++D +RI+DFGL+ +A ++M + T +Y APE++ Sbjct: 182 YMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVL 241 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH 254 Y++ D+WS G I+ LL G F G++ D LK++ Sbjct: 242 HGT--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKV------------------E 281 Query: 255 ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 Y LP ++ + A DL+ +ML R+SA +AL H + Y Sbjct: 282 KGKYTFELPQ---------WKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTY 329 >4RGJ-A nrPDB Length = 520 Score = 117 bits (292), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 92/320 (28%), Positives = 153/320 (47%), Gaps = 57/320 (17%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 61 S R G + Q N E + +G++ +G G++G V + D + A+K +S+ Sbjct: 43 SKLRPGMFIQNSNVVFNE---QYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKK--- 96 Query: 62 LIHARRT------YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTL-MGADL- 113 H +R RE+ LLK L H N++ L + F ED + YLV+ + G +L Sbjct: 97 --HVKRKTDKESLLREVELLKMLDHINIMKLYEFF------EDNNYYYLVSDVYTGGELF 148 Query: 114 NNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAV----NEDCELRILDF 169 + I+ + + ++ Q+L G+ Y+H ++HRDLKP N+ + ED ++I+DF Sbjct: 149 DEIISRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDF 208 Query: 170 GLARQAD--EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD 227 GL+ + ++M + T +Y AP+++ Y++ DIWS G I+ LL G F GS+ Sbjct: 209 GLSTHFEYSKKMKDKIGTAYYIAPDVLHGT--YDEKCDIWSCGVILYILLSGCPPFNGSN 266 Query: 228 YIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGR 287 D LK++ A Y LP F+ + A DL+ + Sbjct: 267 EYDILKKV------------------EAGKYTFDLPQ---------FKKISDKAKDLIKK 299 Query: 288 MLVLDSDQRVSAAEALAHAY 307 ML+ S R+SA +AL H + Sbjct: 300 MLMYTSAVRISARDALEHEW 319 >3IS5-A nrPDB Length = 285 Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 90/294 (30%), Positives = 139/294 (47%), Gaps = 48/294 (16%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 R +GSGA+G V + + +K +++ +S + + E+ +LK L H N+I + Sbjct: 28 RKLGSGAFGDVHLVEERSSGLERVIKTINKD-RSQVPMEQIEAEIEVLKSLDHPNIIKIF 86 Query: 88 DVFTPATSIEDFSEVYLV--TTLMGADLNNIVKCQA----LSDEHVQFLVYQLLRGLKYI 141 +VF ED+ +Y+V T G L IV QA LS+ +V L+ Q++ L Y Sbjct: 87 EVF------EDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYF 140 Query: 142 HSAGIIHRDLKPSNVAVNED---CELRILDFGLAR--QADEEMTGYVATRWYRAPEIMLN 196 HS ++H+DLKP N+ + ++I+DFGLA ++DE T T Y APE+ Sbjct: 141 HSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVFKR 200 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHAR 256 + + DIWS G +M LL G + GT EV K + + Sbjct: 201 DVTFK--CDIWSAGVVMYFLLTG---------------CLPFTGTSLEEVQQKATYKEPN 243 Query: 257 TYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 ++ P PQ A+DLL +ML D ++R SAA+ L H +F Q Sbjct: 244 YAVECRPLTPQ-------------AVDLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >2YCR-A nrPDB Length = 323 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 93/322 (28%), Positives = 150/322 (46%), Gaps = 63/322 (19%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR------RTYRELRLLKHLKHE 81 + +GSGA G V A++ + +KVA+K +S+ ++ AR E+ +LK L H Sbjct: 16 KTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHP 75 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLK 139 +I + + F D + Y+V LM G + +V + L + + YQ+L ++ Sbjct: 76 CIIKIKNFF-------DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 128 Query: 140 YIHSAGIIHRDLKPSNVAVN---EDCELRILDFGLARQADEE--MTGYVATRWYRAPEIM 194 Y+H GIIHRDLKP NV ++ EDC ++I DFG ++ E M T Y APE++ Sbjct: 129 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVL 188 Query: 195 LN--WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPS---PEVLAK 249 ++ YN+ VD WS+G I+ L G P S++ Q+ ++ PEV A+ Sbjct: 189 VSVGTAGYNRAVDCWSLGVILFICLSGYP--PFSEHRTQVSLKDQITSGKYNFIPEVWAE 246 Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY-- 307 +S + A+DL+ ++LV+D R + EAL H + Sbjct: 247 VSEK---------------------------ALDLVKKLLVVDPKARFTTEEALRHPWLQ 279 Query: 308 -------FSQYHDPEDEPEAEP 322 F E+E A+P Sbjct: 280 DEDMKRKFQDLLSEENESTAKP 301 >4LFI-A nrPDB Length = 374 Score = 112 bits (280), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 76/257 (29%), Positives = 132/257 (51%), Gaps = 43/257 (16%) Query: 77 HLKHENVIGLLDVF------TPATSIE-----DFSEVYLVTTLMGADLNNIVKCQALSDE 125 H H N+I L D+ TPA E DF +Y L+D Sbjct: 129 HNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILY----------------PKLTDL 172 Query: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLAR--QADEEMTGY 182 ++F +++LL+ L Y HS GI+HRD+KP NV ++ ++ +LR++D+GLA + E Sbjct: 173 EIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR 232 Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL-QGKALFPGSDYIDQLKRIMEVVGT 241 VA+R+++ PE+++++ Y+ ++D+WS G ++A ++ + + F G+ DQL +I++V+GT Sbjct: 233 VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGT 292 Query: 242 PSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFR---------GANPLAIDLLGRMLVLD 292 E K ++ T + M Q R N IDL+ +L D Sbjct: 293 SDFE---KYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYD 349 Query: 293 SDQRVSAAEALAHAYFS 309 +R++A EA+ H +F+ Sbjct: 350 HQERLTAKEAMGHPWFA 366 >3I6U-A nrPDB Length = 419 Score = 110 bits (275), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 87/299 (29%), Positives = 143/299 (47%), Gaps = 54/299 (18%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR------RTYRELRLLKHLKHE 81 + +GSGA G V A++ + +KVA++ +S+ ++ AR E+ +LK L H Sbjct: 141 KTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILKKLNHP 200 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLK 139 +I + + F D + Y+V LM G + +V + L + + YQ+L ++ Sbjct: 201 CIIKIKNFF-------DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 253 Query: 140 YIHSAGIIHRDLKPSNVAVN---EDCELRILDFGLARQADEE--MTGYVATRWYRAPEIM 194 Y+H GIIHRDLKP NV ++ EDC ++I DFG ++ E M T Y APE++ Sbjct: 254 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVL 313 Query: 195 LN--WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPS---PEVLAK 249 ++ YN+ VD WS+G I+ L G P S++ Q+ ++ PEV A+ Sbjct: 314 VSVGTAGYNRAVDCWSLGVILFICLSGYP--PFSEHRTQVSLKDQITSGKYNFIPEVWAE 371 Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 +S + A+DL+ ++LV+D R + EAL H + Sbjct: 372 VSEK---------------------------ALDLVKKLLVVDPKARFTTEEALRHPWL 403 >4IAN-A nrPDB Length = 358 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 102/355 (28%), Positives = 160/355 (45%), Gaps = 73/355 (20%) Query: 7 GFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYD-ARLRQKVAVKKLSRP------- 58 G+YR + + + +R G G + +V A D AR Q+VAVK + Sbjct: 18 GYYRVNIGEVL---DKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG 74 Query: 59 FQSLIHARR--------TYRELRLLKHLKHENVIGLLDVFTP-ATSIEDFSEVYLVTTLM 109 + L ++ + LRL +H H+ + L VF P + ++ + + Y Sbjct: 75 LKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCL--VFEPLSMNLREVLKKY------ 126 Query: 110 GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED-CELRILD 168 G D+ L + V+ QL LK + I+H D+KP N+ VNE L++ D Sbjct: 127 GKDV-------GLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCD 179 Query: 169 FGLARQ-ADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD 227 FG A AD ++T Y+ +R+YRAPEI++ Y+ +D+WSVGC + EL GK LFPG Sbjct: 180 FGSASHVADNDITPYLVSRFYRAPEIIIG-KSYDYGIDMWSVGCTLYELYTGKILFPGKT 238 Query: 228 YIDQLKRIMEVVGTPSPEVLAK--ISSEHARTYIQSLPPM-------------------- 265 LK M++ G +++ K +H + Q+L M Sbjct: 239 NNHMLKLAMDLKGKMPNKMIRKGVFKDQH---FDQNLNFMYIEVDKVTEREKVTVMSTIN 295 Query: 266 PQKDLSSIFRGANPL----------AIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 P KDL + G L DLL ++L+LD +R+S +AL HA+ + Sbjct: 296 PTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 350 >3LIJ-A nrPDB Length = 494 Score = 107 bits (267), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 85/293 (29%), Positives = 140/293 (47%), Gaps = 42/293 (14%) Query: 25 QGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVI 84 Q ++ +GSGAYG V D + A+K + + S + E+ +LK L H N++ Sbjct: 40 QRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNIM 99 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 L D F ED YLV G + I+ ++ ++ Q+L G+ Y+H Sbjct: 100 KLYDFF------EDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLH 153 Query: 143 SAGIIHRDLKPSNVAV---NEDCELRILDFGLAR--QADEEMTGYVATRWYRAPEIMLNW 197 I+HRDLKP N+ + +D ++I+DFGL+ + ++M + T +Y APE++ Sbjct: 154 KHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVLRK- 212 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257 Y++ D+WS+G I+ LL G F G DQ E+L K+ E + Sbjct: 213 -KYDEKCDVWSIGVILFILLAGYPPFGGQ--TDQ-------------EILRKV--EKGKY 254 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 S P+ ++ + A DL+ +ML DS +R+SA +AL H + + Sbjct: 255 TFDS----PE------WKNVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKE 297 >2F57-A nrPDB Length = 317 Score = 107 bits (267), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 79/288 (27%), Positives = 138/288 (47%), Gaps = 51/288 (17%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR--TYRELRLLKHLKHENVIGLL 87 +G G+ G VC A + ++VAVKK+ Q RR + E+ +++ H+NV+ + Sbjct: 53 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQ----RRELLFNEVVIMRDYHHDNVVDMY 108 Query: 88 DVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 + E+++V + G L +IV +++E + + +LR L Y+H+ G+ Sbjct: 109 SSYLVG------DELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGV 162 Query: 147 IHRDLKPSNVAVNEDCELRILDFGLARQADEEM---TGYVATRWYRAPEIMLNWMHYNQT 203 IHRD+K ++ + D +++ DFG Q +E+ V T ++ APE+ ++ + Y Sbjct: 163 IHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEV-ISRLPYGTE 221 Query: 204 VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLP 263 VDIWS+G ++ E++ G+ + + ++RI + SLP Sbjct: 222 VDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRD-----------------------SLP 258 Query: 264 PMPQKDL---SSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 P KDL SS+ RG L MLV + QR +A E L H + Sbjct: 259 PR-VKDLHKVSSVLRG-------FLDLMLVREPSQRATAQELLGHPFL 298 >2WO6-A nrPDB Length = 382 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 85/326 (26%), Positives = 156/326 (47%), Gaps = 48/326 (14%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G G++G V AYD ++ VA+K + L A+ R L L+ KH+ + V Sbjct: 62 IGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMN--KHDTEMKYYIV 119 Query: 90 FTPATSIEDFSEVYLVTTLMGADLNNIVK---CQALSDEHVQFLVYQLLRGLKYIHS--A 144 + + + LV ++ +L ++++ + +S + Q+ L ++ + Sbjct: 120 HLKRHFMFR-NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPEL 178 Query: 145 GIIHRDLKPSNVAVN--EDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQ 202 IIH DLKP N+ + + ++I+DFG + Q + + Y+ +R+YR+PE++L M Y+ Sbjct: 179 SIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLG-MPYDL 237 Query: 203 TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSL 262 +D+WS+GCI+ E+ G+ LF G++ +DQ+ +I+EV+G P +L + + AR + + L Sbjct: 238 AIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQ--APKARKFFEKL 295 Query: 263 P-----------------PMPQKDLSSIF-----------RGANPLAI-------DLLGR 287 P P + L +I G + + DL+ R Sbjct: 296 PDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILR 355 Query: 288 MLVLDSDQRVSAAEALAHAYFSQYHD 313 ML D R+ AL H++F + D Sbjct: 356 MLDYDPKTRIQPYYALQHSFFKKTAD 381 >5X8I-B nrPDB Length = 346 Score = 105 bits (263), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 82/327 (25%), Positives = 143/327 (43%), Gaps = 50/327 (15%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 R + + +G GA+G V D + + K+ + A R+ E+++L+HL + Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARS--EIQVLEHLNTTD 71 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQAL---SDEHVQFLVYQLLRGLK 139 E + +V L+G + +K +H++ + YQ+ + + Sbjct: 72 PNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVN 131 Query: 140 YIHSAGIIHRDLKPSNVA---------------------VNEDCELRILDFGLARQADEE 178 ++HS + H DLKP N+ +N D ++++DFG A DE Sbjct: 132 FLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPD--IKVVDFGSATYDDEH 189 Query: 179 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 238 + V+TR YRAPE++L + ++Q D+WS+GCI+ E G +FP D + L + + Sbjct: 190 HSTLVSTRHYRAPEVILA-LGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERI 248 Query: 239 VGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSS----IFRGANPLA------------- 281 +G P P+ + I R Y + + SS + R PL Sbjct: 249 LG-PLPKHM--IQKTRKRKYFHH-DRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERL 304 Query: 282 IDLLGRMLVLDSDQRVSAAEALAHAYF 308 DL+ +ML D +R++ EAL H +F Sbjct: 305 FDLIQKMLEYDPAKRITLREALKHPFF 331 >3Q5I-A nrPDB Length = 504 Score = 104 bits (260), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 87/304 (28%), Positives = 136/304 (44%), Gaps = 55/304 (18%) Query: 27 LRPVGSGAYGSV--CSAYDARLRQKVAVKKLSRPFQSLIHA----------RRTYRELRL 74 +R +GSGAYG V C + + + V K S+ F ++ Y E+ L Sbjct: 41 VRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQ-FDKGRYSDDNKNIEKFHEEIYNEISL 99 Query: 75 LKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVY 132 LK L H N+I L DVF ED YLVT G I+ + ++ Sbjct: 100 LKSLDHPNIIKLFDVF------EDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMK 153 Query: 133 QLLRGLKYIHSAGIIHRDLKPSNVAV---NEDCELRILDFGLAR--QADEEMTGYVATRW 187 Q+L G+ Y+H I+HRD+KP N+ + N ++I+DFGL+ D ++ + T + Sbjct: 154 QILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAY 213 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 247 Y APE++ YN+ D+WS G IM LL G F G + D +K++ Sbjct: 214 YIAPEVLKK--KYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKV------------ 259 Query: 248 AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 E + Y D + ++ + A +L+ ML D ++R +A EAL + Sbjct: 260 -----EKGKYYF---------DFND-WKNISDEAKELIKLMLTYDYNKRCTAEEALNSRW 304 Query: 308 FSQY 311 +Y Sbjct: 305 IKKY 308 >4MVF-A nrPDB Length = 506 Score = 103 bits (258), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 80/288 (27%), Positives = 138/288 (47%), Gaps = 44/288 (15%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G G YG V D Q A+K+ + L + R ++E+ ++K L H N++ L + Sbjct: 65 LGQGTYGCVYKGIDKVTNQLYAIKEEKK--DRLKNINRFFQEIEIMKKLDHPNIVKLYET 122 Query: 90 FTPATSIEDFSEVYLVTTLM-GADL-NNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 + E+ + +YL+ L G +L ++I++ + ++++ ++ Q+ + Y+HS I+ Sbjct: 123 Y------ENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIV 176 Query: 148 HRDLKPSNV---AVNEDCELRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWMHYNQ 202 HRDLKP N + N+D L+I+DFGL++ E T T +Y AP+++ Y++ Sbjct: 177 HRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG--KYDK 234 Query: 203 TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSL 262 DIWS G IM LL G F G EVL K+ Y Sbjct: 235 KCDIWSSGVIMYTLLCGYPPF---------------YGDTDNEVLKKVKKGEFCFY---- 275 Query: 263 PPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + D SI A +L+ ++L + ++R + EAL H + +Q Sbjct: 276 ----ENDWGSISSDAK----NLITKLLTYNPNERCTIEEALNHPWITQ 315 >4YZB-A nrPDB Length = 491 Score = 102 bits (254), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 87/294 (29%), Positives = 145/294 (49%), Gaps = 43/294 (14%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLS-RPFQSLIHARRTYRELRLLKHLKHE 81 R +G R +G G++G V D Q+ AVK +S R + +E+ LLK L H Sbjct: 31 RYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHP 90 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTL-MGADL-NNIVKCQALSDEHVQFLVYQLLRGLK 139 N++ L + F ED YLVT + G +L + I+ + S+ ++ Q+L G+ Sbjct: 91 NIMKLYEFF------EDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGIT 144 Query: 140 YIHSAGIIHRDLKPSNVAVN---EDCELRILDFGLAR--QADEEMTGYVATRWYRAPEIM 194 Y+H I+HRDLKP N+ + +D +RI+DFGL+ ++ ++M + T +Y APE++ Sbjct: 145 YMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVL 204 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH 254 Y++ D+WS G I+ LL G F G++ D LK++ + K + + Sbjct: 205 HG--TYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEK----------GKFTFD- 251 Query: 255 ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 +PQ ++ + A DL+ +ML R+SA +AL H + Sbjct: 252 ----------LPQ------WKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWL 289 >4NIF-A nrPDB Length = 333 Score = 102 bits (254), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 80/250 (32%), Positives = 125/250 (50%), Gaps = 48/250 (19%) Query: 74 LLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLV 131 LL++ +H N+I L DV+ +D VYLVT LM G L+ I++ + S+ F++ Sbjct: 55 LLRYGQHPNIITLKDVY------DDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVL 108 Query: 132 YQLLRGLKYIHSAGIIHRDLKPSNV-----AVNEDCELRILDFGLARQADEEMTGYVATR 186 + + + ++Y+HS G++HRDLKPSN+ + N +C LRI DFG A+Q E G + T Sbjct: 109 HTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPEC-LRICDFGFAKQLRAE-NGLLMTP 166 Query: 187 WYR----APEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG--SDYIDQLKRIMEVVG 240 Y APE+ L Y++ DIWS+G ++ +L G F SD Sbjct: 167 CYTANFVAPEV-LKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSD------------- 212 Query: 241 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 300 TP E+L +I S + + A DL+ +ML +D QR++A Sbjct: 213 TPE-EILTRIGSGKFTLS------------GGNWNTVSETAKDLVSKMLHVDPHQRLTAK 259 Query: 301 EALAHAYFSQ 310 + L H + +Q Sbjct: 260 QVLQHPWVTQ 269 >5D9K-A nrPDB Length = 330 Score = 101 bits (251), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 75/239 (31%), Positives = 123/239 (51%), Gaps = 23/239 (9%) Query: 21 PQRLQGLRPVGSGAYGSV-----CSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLL 75 P + + L+ +G G++G V S DAR Q A+K L + + RT E +L Sbjct: 29 PSQFELLKVLGQGSFGKVFLVKKISGSDAR--QLYAMKVLKKATLKVRDRVRTKMERDIL 86 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADL-NNIVKCQALSDEHVQFLVYQ 133 + H ++ L F ++YL+ + G DL + K ++E V+F + + Sbjct: 87 VEVNHPFIVKLHYAFQTE------GKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAE 140 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGY--VATRWYRA 190 L L ++HS GII+RDLKP N+ ++E+ +++ DFGL++++ D E Y T Y A Sbjct: 141 LALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMA 200 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV-VGTP---SPE 245 PE+ +N + Q+ D WS G +M E+L G F G D + + I++ +G P SPE Sbjct: 201 PEV-VNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPE 258 >4FIE-A nrPDB Length = 423 Score = 101 bits (251), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 76/291 (26%), Positives = 139/291 (47%), Gaps = 45/291 (15%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT--YRELRLLKHLKHENVIGLL 87 +G G+ G VC A + VAVKK+ Q RR + E+ +++ +HENV+ + Sbjct: 159 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQ----RRELLFNEVVIMRDYQHENVVEMY 214 Query: 88 DVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 + + E+++V + G L +IV +++E + + +L+ L +H+ G+ Sbjct: 215 NSYLVG------DELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGV 268 Query: 147 IHRDLKPSNVAVNEDCELRILDFGLARQADEEM---TGYVATRWYRAPEIMLNWMHYNQT 203 IHRD+K ++ + D +++ DFG Q +E+ V T ++ APE +++ + Y Sbjct: 269 IHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPE 327 Query: 204 VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLP 263 VDIWS+G ++ E++ G+ + + +K I + +LP Sbjct: 328 VDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD-----------------------NLP 364 Query: 264 PMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 314 P K+L + +P L R+LV D QR +AAE L H + ++ P Sbjct: 365 PR-LKNLHKV----SPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 410 >4KS7-A nrPDB Length = 292 Score = 100 bits (250), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 76/291 (26%), Positives = 137/291 (47%), Gaps = 43/291 (14%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR--TYRELRLLKHLKHENVIGLL 87 +G G+ G VC A + ++VAVK + Q RR + E+ +++ +H NV+ + Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQ----RRELLFNEVVIMRDYQHFNVVEMY 86 Query: 88 DVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 + + L+ L G L +IV L++E + + +L+ L Y+H+ G+I Sbjct: 87 KSYLVGEELW-----VLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVI 141 Query: 148 HRDLKPSNVAVNEDCELRILDFGLARQADEEM---TGYVATRWYRAPEIMLNWMHYNQTV 204 HRD+K ++ + D +++ DFG Q +++ V T ++ APE++ + Y V Sbjct: 142 HRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL-YATEV 200 Query: 205 DIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPP 264 DIWS+G ++ E++ G+ + + +KR+ + +P P K+ + H Sbjct: 201 DIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRD---SPPP----KLKNSHK--------- 244 Query: 265 MPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPE 315 +P+ D L RMLV D +R +A E L H + Q PE Sbjct: 245 ------------VSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPE 283 >3DXN-A nrPDB Length = 287 Score = 100 bits (250), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 87/318 (27%), Positives = 142/318 (44%), Gaps = 50/318 (15%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQ 60 S R Y Q L+ R Q ++ +GSGAYG V D + A+K + + Sbjct: 8 SSGRENLYFQGLS-------DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVT 60 Query: 61 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVK 118 + ++ E+ +LK L H N++ L + F ED YLV + G + I+ Sbjct: 61 TTSNSGALLDEVAVLKQLDHPNIMKLYEFF------EDKRNYYLVMEVYRGGELFDEIIL 114 Query: 119 CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAV---NEDCELRILDFGLAR-- 173 Q S+ ++ Q+L G Y+H I+HRDLKP N+ + + D ++I+DFGL+ Sbjct: 115 RQKFSEVDAAVIMKQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHF 174 Query: 174 QADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLK 233 + +M + T +Y APE++ Y++ D+WS G I+ LL G F G + LK Sbjct: 175 EVGGKMKERLGTAYYIAPEVLRK--KYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILK 232 Query: 234 RIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDS 293 R+ + + P ++S E A L+ ML + Sbjct: 233 RVEKGKFSFDPPDWTQVSDE---------------------------AKQLVKLMLTYEP 265 Query: 294 DQRVSAAEALAHAYFSQY 311 +R+SA EAL H + ++ Sbjct: 266 SKRISAEEALNHPWIVKF 283 >3D2K-A nrPDB Length = 272 Score = 100 bits (249), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 81/287 (28%), Positives = 125/287 (43%), Gaps = 48/287 (16%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA----RRTYRELRLLKHLKHENV 83 RP+G G +G+V Y AR RQ + L F++ + + RE+ + HL+H N+ Sbjct: 18 RPLGKGKFGNV---YLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPNI 74 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTL--MGADLNNIVKCQALSDEHVQFLVYQLLRGLKYI 141 + L F AT VYL+ +G + K ++ + +L L Y Sbjct: 75 LRLYGYFHDAT------RVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYC 128 Query: 142 HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRWYRAPEIMLNWMHY 200 HS +IHRD+KP N+ + + EL+I DFG + A T T Y PE++ MH Sbjct: 129 HSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMH- 187 Query: 201 NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQ 260 ++ VD+WS+G + E L G F Y + +RI V T +E AR Sbjct: 188 DEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFT-----FPDFVTEGAR---- 238 Query: 261 SLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 DL+ R+L ++ QR++ AE L H + Sbjct: 239 ----------------------DLISRLLKHNASQRLTLAEVLEHPW 263 >6FYV-A nrPDB Length = 337 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 81/325 (24%), Positives = 142/325 (43%), Gaps = 46/325 (14%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 R + + +G GA+G V D + K+ + A R+ E+++L+HL + Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARS--EIQVLEHLNSTD 72 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQAL---SDEHVQFLVYQLLRGLK 139 + + V +V L+G + +K + +H++ + YQ+ + + Sbjct: 73 PNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSIN 132 Query: 140 YIHSAGIIHRDLKPSNVAVNE-------------------DCELRILDFGLARQADEEMT 180 ++H + H DLKP N+ + + +++++DFG A DE + Sbjct: 133 FLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHS 192 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240 V+TR YRAPE++L + ++Q D+WS+GCI+ E G +F D + L +ME + Sbjct: 193 TLVSTRHYRAPEVILA-LGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLA-MMERIL 250 Query: 241 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSS----IFRGANPLA-------------ID 283 P P+ + I R Y + + SS + R PL D Sbjct: 251 GPIPQHM--IQKTRKRKYFHH-NQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFD 307 Query: 284 LLGRMLVLDSDQRVSAAEALAHAYF 308 L+ RML D QR++ EAL H +F Sbjct: 308 LVRRMLEYDPTQRITLDEALQHPFF 332 >6FD3-A nrPDB Length = 300 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 77/286 (26%), Positives = 140/286 (48%), Gaps = 47/286 (16%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLS---RPFQSLIHARRTYRELRLLKHLKHENVIGL 86 +G GA G+V +A D Q+VA+K+++ +P + LI E+ +++ K+ N++ Sbjct: 30 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELI-----INEILVMRENKNPNIVNY 84 Query: 87 LDVFTPATSIEDFSEVYLVTT-LMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAG 145 LD + E+++V L G L ++V + + + + + L+ L ++HS Sbjct: 85 LDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQ 138 Query: 146 IIHRDLKPSNVAVNEDCELRILDFGLARQADEEM---TGYVATRWYRAPEIMLNWMHYNQ 202 +IHRD+K N+ + D +++ DFG Q E + V T ++ APE++ Y Sbjct: 139 VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR-KAYGP 197 Query: 203 TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSL 262 VDIWS+G + E+++G+ + + + L ++ GTP +Q+ Sbjct: 198 KVDIWSLGIMAIEMVEGEPPYLNENPLRAL-YLIATNGTPE---------------LQN- 240 Query: 263 PPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 P++ LS++FR D L R L +D D+R SA E L H + Sbjct: 241 ---PER-LSAVFR-------DFLNRCLEMDVDRRGSAKELLQHPFL 275 >4JDH-A nrPDB Length = 346 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 76/291 (26%), Positives = 139/291 (47%), Gaps = 45/291 (15%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR--TYRELRLLKHLKHENVIGLL 87 +G G+ G VC A + VAVKK+ Q RR + E+ +++ +HENV+ + Sbjct: 82 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQ----RRELLFNEVVIMRDYQHENVVEMY 137 Query: 88 DVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 + + E+++V + G L +IV +++E + + +L+ L +H+ G+ Sbjct: 138 NSYLVG------DELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGV 191 Query: 147 IHRDLKPSNVAVNEDCELRILDFGLARQADEEM---TGYVATRWYRAPEIMLNWMHYNQT 203 IHRD+K ++ + D +++ DFG Q +E+ V T ++ APE +++ + Y Sbjct: 192 IHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPE 250 Query: 204 VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLP 263 VDIWS+G ++ E++ G+ + + +K I + +LP Sbjct: 251 VDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD-----------------------NLP 287 Query: 264 PMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 314 P K+L + +P L R+LV D QR +AAE L H + ++ P Sbjct: 288 PR-LKNLHKV----SPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 333 >3RAW-A nrPDB Length = 381 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 87/327 (26%), Positives = 142/327 (43%), Gaps = 42/327 (12%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYD-ARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL 78 + +R + + +G G +G V D AR + +VA+K + R A R E+ +LK + Sbjct: 49 LQERYEIVGNLGEGTFGKVVECLDHARGKSQVALK-IIRNVGKYREAARL--EINVLKKI 105 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK---CQALSDEHVQFLVYQLL 135 K ++ + + + L+G + +K Q HV+ + YQL Sbjct: 106 KEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLC 165 Query: 136 RGLKYIHSAGIIHRDLKPSNVAV-----------NEDCE--------LRILDFGLARQAD 176 L+++H + H DLKP N+ ++ CE +R+ DFG A Sbjct: 166 HALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDH 225 Query: 177 EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 E T VATR YR PE++L + + Q D+WS+GCI+ E +G LF + + L + Sbjct: 226 EHHTTIVATRHYRPPEVILE-LGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMME 284 Query: 237 EVVGTPSPEVLAKISSEHARTYIQSLP-PMPQKDLSSIFRGANPLA-------------I 282 +++G P P + + + Y L D + PL Sbjct: 285 KILG-PIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLF 343 Query: 283 DLLGRMLVLDSDQRVSAAEALAHAYFS 309 DL+ RML D QR++ AEAL H +F+ Sbjct: 344 DLMRRMLEFDPAQRITLAEALLHPFFA 370 >3Q53-A nrPDB Length = 306 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 76/286 (26%), Positives = 141/286 (49%), Gaps = 47/286 (16%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLS---RPFQSLIHARRTYRELRLLKHLKHENVIGL 86 +G GA G+V +A D Q+VA+++++ +P + LI E+ +++ K+ N++ Sbjct: 29 IGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELI-----INEILVMRENKNPNIVNY 83 Query: 87 LDVFTPATSIEDFSEVYLVTT-LMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAG 145 LD + E+++V L G L ++V + + + + + L+ L+++HS Sbjct: 84 LDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQ 137 Query: 146 IIHRDLKPSNVAVNEDCELRILDFGLARQADEEM---TGYVATRWYRAPEIMLNWMHYNQ 202 +IHRD+K N+ + D +++ DFG Q E + V T ++ APE++ Y Sbjct: 138 VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR-KAYGP 196 Query: 203 TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSL 262 VDIWS+G + E+++G+ + + + L ++ GTP +Q+ Sbjct: 197 KVDIWSLGIMAIEMIEGEPPYLNENPLRAL-YLIATNGTPE---------------LQN- 239 Query: 263 PPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 P+K LS+IFR D L R L +D ++R SA E + H + Sbjct: 240 ---PEK-LSAIFR-------DFLNRCLEMDVEKRGSAKELIQHQFL 274 >4WNO-A nrPDB Length = 287 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 69/215 (32%), Positives = 111/215 (51%), Gaps = 30/215 (13%) Query: 30 VGSGAYGSVC-----SAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVI 84 +G GA+ V +A+D + K KK Q+L+ +E+++LK LKHEN++ Sbjct: 26 IGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLG-----KEIKILKELKHENIV 80 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKC-QALSDEHVQFLVYQLLRGLKYIH 142 L D A S VYLV G DL + + + LS++ ++ + Q+ ++ +H Sbjct: 81 ALYDFQEMANS------VYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLH 134 Query: 143 SAGIIHRDLKPSNVAVN---------EDCELRILDFGLAR--QADEEMTGYVATRWYRAP 191 S GIIHRDLKP N+ ++ ++I DFG AR Q++ + Y AP Sbjct: 135 SKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAP 194 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGS 226 E++++ HY+ D+WS+G I+ + L GKA F S Sbjct: 195 EVIMS-QHYDGKADLWSIGTIVYQCLTGKAPFQAS 228 >2Q0N-A nrPDB Length = 301 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 76/291 (26%), Positives = 139/291 (47%), Gaps = 45/291 (15%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR--TYRELRLLKHLKHENVIGLL 87 +G G+ G VC A + VAVKK+ Q RR + E+ +++ +HENV+ + Sbjct: 37 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQ----RRELLFNEVVIMRDYQHENVVEMY 92 Query: 88 DVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 + + E+++V + G L +IV +++E + + +L+ L +H+ G+ Sbjct: 93 NSYLVG------DELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGV 146 Query: 147 IHRDLKPSNVAVNEDCELRILDFGLARQADEEM---TGYVATRWYRAPEIMLNWMHYNQT 203 IHRD+K ++ + D +++ DFG Q +E+ V T ++ APE +++ + Y Sbjct: 147 IHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPE 205 Query: 204 VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLP 263 VDIWS+G ++ E++ G+ + + +K I + +LP Sbjct: 206 VDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD-----------------------NLP 242 Query: 264 PMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 314 P K+L + +P L R+LV D QR +AAE L H + ++ P Sbjct: 243 PR-LKNLHKV----SPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 288 >3HZT-A nrPDB Length = 467 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 82/300 (27%), Positives = 137/300 (45%), Gaps = 43/300 (14%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQSLIHARRTYRELRLLKHL 78 + R Q ++ +GSGAYG V D + A+K + + + ++ E+ +LK L Sbjct: 2 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 61 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLR 136 H N++ L + F ED YLV + G + I+ Q S+ ++ Q+L Sbjct: 62 DHPNIMKLYEFF------EDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLS 115 Query: 137 GLKYIHSAGIIHRDLKPSNVAV---NEDCELRILDFGLAR--QADEEMTGYVATRWYRAP 191 G Y+H I+HRDLKP N+ + + D ++I+DFGL+ + +M + T +Y AP Sbjct: 116 GTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAP 175 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 E++ Y++ D+WS G I+ LL G F G + LKR+ + + P ++S Sbjct: 176 EVLRK--KYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVS 233 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 E A L+ ML + +R+SA EAL H + ++ Sbjct: 234 DE---------------------------AKQLVKLMLTYEPSKRISAEEALNHPWIVKF 266 >2OU7-A nrPDB Length = 335 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 81/293 (27%), Positives = 129/293 (44%), Gaps = 40/293 (13%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR-RTYRELRLLKHLKHENVIGLLD 88 +G G + DA ++ A K + + H R + E+ + + L H++V+G Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 89 VFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIH 148 F DF V L + L + +AL++ ++ + Q++ G +Y+H +IH Sbjct: 109 FFED----NDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIH 164 Query: 149 RDLKPSNVAVNEDCELRILDFGLARQAD---EEMTGYVATRWYRAPEIMLNWMHYNQTVD 205 RDLK N+ +NED E++I DFGLA + + E T Y APE++ H + VD Sbjct: 165 RDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFE-VD 223 Query: 206 IWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPM 265 +WS+GCIM LL GK F S + RI Sbjct: 224 VWSIGCIMYTLLVGKPPFETSCLKETYLRI------------------------------ 253 Query: 266 PQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEP 318 +K+ SI + NP+A L+ +ML D R + E L +F+ + P P Sbjct: 254 -KKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLP 305 >4XBR-A nrPDB Length = 366 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 76/291 (26%), Positives = 139/291 (47%), Gaps = 45/291 (15%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR--TYRELRLLKHLKHENVIGLL 87 +G G+ G VC A + VAVKK+ Q RR + E+ +++ +HENV+ + Sbjct: 102 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQ----RRELLFNEVVIMRDYQHENVVEMY 157 Query: 88 DVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 + + E+++V + G L +IV +++E + + +L+ L +H+ G+ Sbjct: 158 NSYLVG------DELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGV 211 Query: 147 IHRDLKPSNVAVNEDCELRILDFGLARQADEEM---TGYVATRWYRAPEIMLNWMHYNQT 203 IHRD+K ++ + D +++ DFG Q +E+ V T ++ APE +++ + Y Sbjct: 212 IHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPE 270 Query: 204 VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLP 263 VDIWS+G ++ E++ G+ + + +K I + +LP Sbjct: 271 VDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD-----------------------NLP 307 Query: 264 PMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 314 P K+L + +P L R+LV D QR +AAE L H + ++ P Sbjct: 308 PR-LKNLHKV----SPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 353 >3H4J-B nrPDB Length = 336 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 84/309 (27%), Positives = 148/309 (47%), Gaps = 45/309 (14%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPF--QSLIHARRTYRELRLLKHLKHENVIGLL 87 +G G++G V A + +QKVA+K +SR +S +H R RE+ LK L+H ++I L Sbjct: 17 LGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMR-VEREISYLKLLRHPHIIKLY 75 Query: 88 DVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 DV T T I V ++ G + IV+ + ++++ + Q++ ++Y H I+ Sbjct: 76 DVITTPTDI-----VMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRHKIV 130 Query: 148 HRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVATRWYRAPEIMLNWMHYNQTVD 205 HRDLKP N+ ++++ ++I DFGL+ + + + Y APE++ ++ VD Sbjct: 131 HRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGPEVD 190 Query: 206 IWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPM 265 +WS G ++ +L G+ F ++I P + K++S + M Sbjct: 191 VWSCGIVLYVMLVGRLPF-DDEFI--------------PNLFKKVNS--------CVYVM 227 Query: 266 PQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS----QYHDPEDEPEAE 321 P D S P A L+ RM+V D QR++ E +F+ Y P +E + Sbjct: 228 P--DFLS------PGAQSLIRRMIVADPMQRITIQEIRRDPWFNVNLPDYLRPMEEVQGS 279 Query: 322 PYDESVEAK 330 D + +K Sbjct: 280 YADSRIVSK 288 >4UZD-A nrPDB Length = 287 Score = 98.6 bits (244), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 68/218 (31%), Positives = 104/218 (47%), Gaps = 17/218 (7%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA----RRTYRELRLLKHLKHENV 83 RP+G G +G+V Y AR +Q + L F++ + + RE+ + HL+H N+ Sbjct: 14 RPLGKGKFGNV---YLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNI 70 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTL--MGADLNNIVKCQALSDEHVQFLVYQLLRGLKYI 141 + L F AT VYL+ +G + K ++ + +L L Y Sbjct: 71 LRLYGYFHDAT------RVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYC 124 Query: 142 HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRWYRAPEIMLNWMHY 200 HS +IHRD+KP N+ + EL+I DFG + A T T Y PE++ MH Sbjct: 125 HSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMH- 183 Query: 201 NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 238 ++ VD+WS+G + E L GK F + Y + KRI V Sbjct: 184 DEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRV 221 >4J52-A nrPDB Length = 293 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 81/293 (27%), Positives = 129/293 (44%), Gaps = 40/293 (13%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR-RTYRELRLLKHLKHENVIGLLD 88 +G G + DA ++ A K + + H R + E+ + + L H++V+G Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 89 VFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIH 148 F DF V L + L + +AL++ ++ + Q++ G +Y+H +IH Sbjct: 82 FFED----NDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIH 137 Query: 149 RDLKPSNVAVNEDCELRILDFGLARQAD---EEMTGYVATRWYRAPEIMLNWMHYNQTVD 205 RDLK N+ +NED E++I DFGLA + + E T Y APE++ H + VD Sbjct: 138 RDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFE-VD 196 Query: 206 IWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPM 265 +WS+GCIM LL GK F S + RI Sbjct: 197 VWSIGCIMYTLLVGKPPFETSCLKETYLRI------------------------------ 226 Query: 266 PQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEP 318 +K+ SI + NP+A L+ +ML D R + E L +F+ + P P Sbjct: 227 -KKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLP 278 >6E2O-A nrPDB Length = 295 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 79/268 (29%), Positives = 131/268 (48%), Gaps = 32/268 (11%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G G YG V + D + ++A+K++ P + +++ + E+ L KHLKH+N++ L Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKHLKHKNIVQYLGS 87 Query: 90 FTPATSIEDFSEVYLVTTLMGADLNNIVKCQ----ALSDEHVQFLVYQLLRGLKYIHSAG 145 F+ I+ F E + G L+ +++ + +++ + F Q+L GLKY+H Sbjct: 88 FSENGFIKIFME-----QVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQ 142 Query: 146 IIHRDLKPSNVAVNE-DCELRILDFGLARQ------ADEEMTGYVATRWYRAPEIMLNW- 197 I+HRD+K NV +N L+I DFG +++ E TG T Y APEI+ Sbjct: 143 IVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTG---TLQYMAPEIIDKGP 199 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG--TPSPEVLAKISSEHA 255 Y + DIWS+GC + E+ GK F + + + M VG PE+ +S+E Sbjct: 200 RGYGKAADIWSLGCTIIEMATGKPPFY---ELGEPQAAMFKVGMFKVHPEIPESMSAEAK 256 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAID 283 ++ P P K AN L +D Sbjct: 257 AFILKCFEPDPDKRAC-----ANDLLVD 279 >5XZW-A nrPDB Length = 471 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 86/274 (31%), Positives = 134/274 (48%), Gaps = 29/274 (10%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 VG GA+ +V A + + AVK +S+ + + + REL +L+ L H ++ L Sbjct: 204 VGQGAFATVKKAIERTTGKTFAVKIISKR-KVIGNMDGVTRELEVLQKLNHPRIVRLKGF 262 Query: 90 FTPATSIEDFSEVYLVTTLM-GADLNNIVKCQ-ALSDEHVQFLVYQLLRGLKYIHSAGII 147 + ED Y+V + G DL + V A+ ++ + + Q+L +KYIHS GI Sbjct: 263 Y------EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGIS 316 Query: 148 HRDLKPSNVAVNED--CELRILDFGLAR-QADEE-MTGYVATRWYRAPEIMLN------- 196 HRDLKP N+ + +D ++I DFGLA+ Q + M + T Y APE++ Sbjct: 317 HRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSP 376 Query: 197 -----WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQL-KRIMEVVGTPSPEVLAKI 250 Y+ VD+WS+GC++ +L G F GS DQL K+I P +I Sbjct: 377 DEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQLYKQIGRGSYHEGPLKDFRI 435 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGAN-PLAID 283 SE AR +I SL + + S+ + N P +D Sbjct: 436 -SEEARDFIDSLLQVDPNNRSTAAKALNHPWIVD 468 >4B6L-A nrPDB Length = 281 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 71/236 (30%), Positives = 114/236 (48%), Gaps = 20/236 (8%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR-RTYRELRLLKHLKHENVIGL 86 R +G G + A D AVK + + + H R + E+ L + L+H +++ Sbjct: 15 RLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRF 74 Query: 87 LDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQ-ALSDEHVQFLVYQLLRGLKYIHSA 144 F ED +Y+ L L +I K + L + V++ + Q+L GLKY+H Sbjct: 75 SHHF------EDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQR 128 Query: 145 GIIHRDLKPSNVAVNEDCELRILDFGLARQ---ADEEMTGYVATRWYRAPEIMLNWMHYN 201 GI+HRDLK N + E+ EL++ DFGLA + ++ T Y APE++L H Sbjct: 129 GILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGH-G 187 Query: 202 QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV-------VGTPSPEVLAKI 250 D+WS+GC+M LL G F +D + + I +V + P+ ++LA I Sbjct: 188 PEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAI 243 >3DB8-A nrPDB Length = 317 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 80/297 (26%), Positives = 133/297 (44%), Gaps = 40/297 (13%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR-RTYRELRLLKHLKHENVIGL 86 R +G G + D ++ A K + + H + + E+ + K L + +V+G Sbjct: 48 RFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPHVVGF 107 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 F +DF V L + L + +A+++ ++ + Q ++G++Y+H+ + Sbjct: 108 HGFFED----DDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRV 163 Query: 147 IHRDLKPSNVAVNEDCELRILDFGLARQAD---EEMTGYVATRWYRAPEIMLNWMHYNQT 203 IHRDLK N+ +N+D +++I DFGLA + + E T Y APE++ H + Sbjct: 164 IHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCKKGHSFE- 222 Query: 204 VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLP 263 VDIWS+GCI+ LL GK F S + RI Sbjct: 223 VDIWSLGCILYTLLVGKPPFETSCLKETYIRI---------------------------- 254 Query: 264 PMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEA 320 +K+ S+ R NP+A L+ RML D R S AE L +F+ + P P + Sbjct: 255 ---KKNEYSVPRHINPVASALIRRMLHADPTLRPSVAELLTDEFFTSGYAPMRLPTS 308 >2Z7Q-A nrPDB Length = 321 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 71/242 (29%), Positives = 119/242 (49%), Gaps = 38/242 (15%) Query: 21 PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR-------------- 66 P + L+ +G G++G V V+K++RP ++A Sbjct: 27 PSHFELLKVLGQGSFGKV-----------FLVRKVTRPDSGHLYAMKVLKKATLKVRDRV 75 Query: 67 RTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADL-NNIVKCQALSD 124 RT E +L + H V+ L F ++YL+ + G DL + K ++ Sbjct: 76 RTKMERDILADVNHPFVVKLHYAFQTE------GKLYLILDFLRGGDLFTRLSKEVMFTE 129 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGY- 182 E V+F + +L GL ++HS GII+RDLKP N+ ++E+ +++ DFGL+++A D E Y Sbjct: 130 EDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS 189 Query: 183 -VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV-VG 240 T Y APE+ +N ++ + D WS G +M E+L G F G D + + I++ +G Sbjct: 190 FCGTVEYMAPEV-VNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLG 248 Query: 241 TP 242 P Sbjct: 249 MP 250 >6CMJ-A nrPDB Length = 321 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 78/297 (26%), Positives = 141/297 (47%), Gaps = 48/297 (16%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVK-----KLSRPFQSLIHAR----RTYRELRLLKHLKH 80 +G G+YG V AY+ A+K KL R I R + Y+E+ +LK L H Sbjct: 42 IGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEIAILKKLDH 101 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDEHVQFLVYQLLRGLK 139 NV+ L++V +Y+V L+ + + + LS++ +F L++G++ Sbjct: 102 PNVVKLVEVLDDPNE----DHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIE 157 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ---ADEEMTGYVATRWYRAPEIM-- 194 Y+H IIHRD+KPSN+ V ED ++I DFG++ + +D ++ V T + APE + Sbjct: 158 YLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSE 217 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH 254 + + +D+W++G + + G+ F +D+ RIM + H Sbjct: 218 TRKIFSGKALDVWAMGVTLYCFVFGQCPF-----MDE--RIMCL---------------H 255 Query: 255 ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 ++ Q+L Q D++ + DL+ RML + + R+ E H + +++ Sbjct: 256 SKIKSQALEFPDQPDIAEDLK-------DLITRMLDKNPESRIVVPEIKLHPWVTRH 305 >4FG9-A nrPDB Length = 320 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 63/198 (31%), Positives = 110/198 (55%), Gaps = 17/198 (8%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTY-RELRLLKHLKHENVIGLLD 88 +G+GA+ V A D R ++ VA+K +++ ++L + E+ +L +KH N++ L D Sbjct: 26 LGTGAFSEVILAEDKRTQKLVAIKCIAK--EALEGKEGSMENEIAVLHKIKHPNIVALDD 83 Query: 89 VFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 ++ E +YL+ L+ G + IV+ ++ L++Q+L +KY+H GI Sbjct: 84 IY------ESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGI 137 Query: 147 IHRDLKPSNV---AVNEDCELRILDFGLARQAD--EEMTGYVATRWYRAPEIMLNWMHYN 201 +HRDLKP N+ +++ED ++ I DFGL++ D ++ T Y APE++ Y+ Sbjct: 138 VHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQ-KPYS 196 Query: 202 QTVDIWSVGCIMAELLQG 219 + VD WS+G I LL G Sbjct: 197 KAVDCWSIGVIAYILLCG 214 >6QAU-A nrPDB Length = 280 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 66/212 (31%), Positives = 114/212 (53%), Gaps = 30/212 (14%) Query: 30 VGSGAYGSVCSAYDARLRQK----VAVKKLSRPFQSLIHARRTY-RELRLLKHLKHENVI 84 VG GA+ V + R RQK VA+K +++ ++L ++ +E+++LK L+HEN++ Sbjct: 19 VGHGAFAVV---FRGRHRQKTDWEVAIKSINK--KNLSKSQILLGKEIKILKELQHENIV 73 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA-LSDEHVQFLVYQLLRGLKYIH 142 L DV S V+LV G DL + ++ + LS++ ++ ++Q+ ++ +H Sbjct: 74 ALYDVQELPNS------VFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILH 127 Query: 143 SAGIIHRDLKPSNVAVN---------EDCELRILDFGLARQADEEMTG--YVATRWYRAP 191 S GIIHRDLKP N+ ++ ++I DFG AR M + Y AP Sbjct: 128 SKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAP 187 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALF 223 E++++ HY+ D+WS+G ++ + L GK F Sbjct: 188 EVIMS-QHYDAKADLWSIGTVIYQCLVGKPPF 218 >4REW-A nrPDB Length = 540 Score = 94.7 bits (234), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 92/327 (28%), Positives = 141/327 (43%), Gaps = 48/327 (14%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 +G G +G V KVAVK L+R +SL + RE++ LK +H ++I L Sbjct: 14 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 73 Query: 89 VFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 V + S++++V + G + I K L ++ + L Q+L G+ Y H + Sbjct: 74 VISTP------SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMV 127 Query: 147 IHRDLKPSNVAVNEDCELRILDFGLARQAD--EEMTGYVATRWYRAPEIMLNWMHYNQTV 204 +HRDLKP NV ++ +I DFGL+ E + + Y APE++ ++ V Sbjct: 128 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEV 187 Query: 205 DIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPP 264 DIWS G I+ LL G F K+I + + +P+ L Sbjct: 188 DIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFY-TPQYL----------------- 229 Query: 265 MPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ----YHDPEDEPEA 320 NP I LL ML +D +R S + H +F Q Y PED P Sbjct: 230 -------------NPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYLFPED-PSY 275 Query: 321 EPYDESVEAKERTLEEWKELTYQEVLS 347 EA + E++ E + +EVLS Sbjct: 276 SSTMIDDEALKEVCEKF-ECSEEEVLS 301 >4JG6-A nrPDB Length = 355 Score = 94.4 bits (233), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 77/249 (30%), Positives = 123/249 (49%), Gaps = 44/249 (17%) Query: 74 LLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLV 131 LL++ +H N+I L DV+ +D VY+VT LM G L+ I++ + S+ ++ Sbjct: 82 LLRYGQHPNIITLKDVY------DDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVL 135 Query: 132 YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDC----ELRILDFGLARQADEEMTGYVATRW 187 + + + ++Y+H+ G++HRDLKPSN+ ++ +RI DFG A+Q E G + T Sbjct: 136 FTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAE-NGLLMTPC 194 Query: 188 YR----APEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFP-GSDYIDQLKRIMEVVGTP 242 Y APE+ L Y+ DIWS+G ++ +L G F G D TP Sbjct: 195 YTANFVAPEV-LERQGYDAACDIWSLGVLLYTMLTGYTPFANGPD------------DTP 241 Query: 243 SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEA 302 E+LA+I S SL + + A DL+ +ML +D QR++AA Sbjct: 242 E-EILARIGSGKF-----SLS-------GGYWNSVSDTAKDLVSKMLHVDPHQRLTAALV 288 Query: 303 LAHAYFSQY 311 L H + + Sbjct: 289 LRHPWIVHW 297 >4PDS-A nrPDB Length = 347 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 85/294 (28%), Positives = 133/294 (45%), Gaps = 52/294 (17%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 VG GA+ +V A + + +VK +S+ + + + REL +L+ L H ++ L Sbjct: 39 VGQGAFATVKKAIERTTGKTFSVKIISKR-KVIGNMDGVTRELEVLQKLNHPRIVRLKGF 97 Query: 90 FTPATSIEDFSEVYLVTTLM-GADLNNIVKCQ-ALSDEHVQFLVYQLLRGLKYIHSAGII 147 + ED Y+V + G DL + V A+ ++ + + Q+L +KYIHS GI Sbjct: 98 Y------EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGIS 151 Query: 148 HRDLKPSNVAVNED--CELRILDFGLAR-QADEE-MTGYVATRWYRAPEIMLN------- 196 HRDLKP N+ + +D ++I FGLA+ Q + M + T Y APE++ Sbjct: 152 HRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSP 211 Query: 197 -----WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 Y+ VD+WS+GC++ +L G F GS K+I P +I Sbjct: 212 DEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRI- 270 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAH 305 SE AR +I SL L +D + R +AA+AL H Sbjct: 271 SEEARDFIDSL--------------------------LQVDPNNRSTAAKALNH 298 >4CFH-A nrPDB Length = 493 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 91/327 (27%), Positives = 141/327 (43%), Gaps = 48/327 (14%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 +G G +G V KVAVK L+R +SL + RE++ LK +H ++I L Sbjct: 41 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 100 Query: 89 VFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 V + S++++V + G + I K L ++ + L Q+L G+ Y H + Sbjct: 101 VISTP------SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMV 154 Query: 147 IHRDLKPSNVAVNEDCELRILDFGLARQAD--EEMTGYVATRWYRAPEIMLNWMHYNQTV 204 +HRDLKP NV ++ +I DFGL+ E + + Y APE++ ++ V Sbjct: 155 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEV 214 Query: 205 DIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPP 264 DIWS G I+ LL G F K+I + + +P+ L Sbjct: 215 DIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFY-TPQYL----------------- 256 Query: 265 MPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ----YHDPEDEPEA 320 NP I LL ML +D +R + + H +F Q Y PED P Sbjct: 257 -------------NPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPED-PSY 302 Query: 321 EPYDESVEAKERTLEEWKELTYQEVLS 347 EA + E++ E + +EVLS Sbjct: 303 SSTMIDDEALKEVCEKF-ECSEEEVLS 328 >2A27-A nrPDB Length = 321 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 85/310 (27%), Positives = 142/310 (45%), Gaps = 50/310 (16%) Query: 30 VGSGAYGSV--CSAYDARLR--QKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIG 85 +GSG + V C L K K+ SR + + RE+ +L+ + H NVI Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 86 LLDVFTPATSIEDFSEVYLVTTLMGADLNN-IVKCQALSDEHVQFLVYQLLRGLKYIHSA 144 L DV+ T + V ++ + G +L + + + ++LS+E + Q+L G+ Y+H+ Sbjct: 80 LHDVYENRTDV-----VLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTK 134 Query: 145 GIIHRDLKPSNVAVNEDC----ELRILDFGLARQADE--EMTGYVATRWYRAPEIMLNWM 198 I H DLKP N+ + + ++++DFGLA + ++ E T + APEI+ N+ Sbjct: 135 KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIV-NYE 193 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 D+WS+G I LL G + F +G E LA I+ A +Y Sbjct: 194 PLGLEADMWSIGVITYILLSGASPF---------------LGDTKQETLANIT---AVSY 235 Query: 259 IQSLPPMPQKDLS-SIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDE 317 D F + LA D + ++LV ++ +R++ EAL H + + P D Sbjct: 236 ----------DFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT----PVDN 281 Query: 318 PEAEPYDESV 327 +A ESV Sbjct: 282 QQAMVRRESV 291 >5TQX-A nrPDB Length = 655 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 65/211 (30%), Positives = 101/211 (47%), Gaps = 17/211 (8%) Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77 WE+ +RL G+G +G+VC L K+A+K R S + R E++++K Sbjct: 10 WEMRERL------GTGGFGNVCLYQHRELDLKIAIKS-CRLELSTKNRERWCHEIQIMKK 62 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK----CQALSDEHVQFLVYQ 133 L H NV+ DV + + + G DL ++ C L + + L+ Sbjct: 63 LNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSD 122 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNE---DCELRILDFGLARQAD--EEMTGYVATRWY 188 + G++Y+H IIHRDLKP N+ + + +I+D G A+ D E T +V T Y Sbjct: 123 IGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQY 182 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQG 219 APE+ N Y TVD WS G ++ E + G Sbjct: 183 LAPELFEN-KPYTATVDYWSFGTMVFECIAG 212 >1ZWS-A nrPDB Length = 288 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 77/291 (26%), Positives = 133/291 (45%), Gaps = 44/291 (15%) Query: 30 VGSGAYGSV--CSAYDARLR--QKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIG 85 +GSG + V C L K K+ SR + + RE+ +L+ + H NVI Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 86 LLDVFTPATSIEDFSEVYLVTTLMGADLNN-IVKCQALSDEHVQFLVYQLLRGLKYIHSA 144 L DV+ T + V ++ + G +L + + + ++LS+E + Q+L G+ Y+H+ Sbjct: 80 LHDVYENRTDV-----VLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTK 134 Query: 145 GIIHRDLKPSNVAVNEDC----ELRILDFGLARQADE--EMTGYVATRWYRAPEIMLNWM 198 I H DLKP N+ + + ++++DFGLA + ++ E T + APEI+ N+ Sbjct: 135 KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIV-NYE 193 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 D+WS+G I LL G + F +G E LA I+S Sbjct: 194 PLGLEADMWSIGVITYILLSGASPF---------------LGDTKQETLANITS------ 232 Query: 259 IQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 + F + LA D + ++LV ++ +R++ EAL H + + Sbjct: 233 ------VSYDFDEEFFSHTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >5JZN-A nrPDB Length = 280 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 85/314 (27%), Positives = 140/314 (44%), Gaps = 53/314 (16%) Query: 11 QELNKTVWEVP----QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR 66 +E+++ +++P +R + R +G G + V + ++ A+K + + + Sbjct: 4 EEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKS-KCRGKEH 62 Query: 67 RTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADL-NNIVKCQALSD 124 E+ +L+ +KH N++ L++ T E+YLV L+ G DL + I ++ Sbjct: 63 MIQNEVSILRRVKHPNIVLLIEEMDVPT------ELYLVMELVKGGDLFDAITSTNKYTE 116 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE----LRILDFGLARQADEEMT 180 ++Y L +KY+HS I+HRD+KP N+ V E + L++ DFGLA D + Sbjct: 117 RDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLY 176 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD-----YIDQLKRI 235 T Y APEI+ Y VDIW+ G I LL G F GS DQ+ + Sbjct: 177 TVCGTPTYVAPEIIAE-TGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQI--L 233 Query: 236 MEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQ 295 M V PSP + + A +L+ ML++D DQ Sbjct: 234 MGQVDFPSP----------------------------YWDNVSDSAKELITMMLLVDVDQ 265 Query: 296 RVSAAEALAHAYFS 309 R SA + L H + + Sbjct: 266 RFSAVQVLEHPWVN 279 >2Y7J-A nrPDB Length = 365 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 74/254 (29%), Positives = 123/254 (48%), Gaps = 45/254 (17%) Query: 68 TYRELRLLKHLK-HENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSD 124 T RE +L+ + H ++I L+D S E S ++LV LM G + + + ALS+ Sbjct: 146 TRRETHILRQVAGHPHIITLID------SYESSSFMFLVFDLMRKGELFDYLTEKVALSE 199 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD--EEMTGY 182 + + ++ LL + ++H+ I+HRDLKP N+ ++++ ++R+ DFG + + E++ Sbjct: 200 KETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLREL 259 Query: 183 VATRWYRAPEIMLNWMH-----YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME 237 T Y APEI+ M Y + VD+W+ G I+ LL G F I L+ IME Sbjct: 260 CGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIME 319 Query: 238 -VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQR 296 SPE D SS + DL+ R+L +D + R Sbjct: 320 GQYQFSSPE---------------------WDDRSSTVK-------DLISRLLQVDPEAR 351 Query: 297 VSAAEALAHAYFSQ 310 ++A +AL H +F + Sbjct: 352 LTAEQALQHPFFER 365 >4RED-A nrPDB Length = 351 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 91/327 (27%), Positives = 140/327 (42%), Gaps = 48/327 (14%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 +G G +G V VAVK L+R +SL + RE++ LK +H ++I L Sbjct: 22 LGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 81 Query: 89 VFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 V + S++++V + G + I K L ++ + L Q+L G+ Y H + Sbjct: 82 VISTP------SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMV 135 Query: 147 IHRDLKPSNVAVNEDCELRILDFGLARQAD--EEMTGYVATRWYRAPEIMLNWMHYNQTV 204 +HRDLKP NV ++ +I DFGL+ E + + Y APE++ ++ V Sbjct: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEV 195 Query: 205 DIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPP 264 DIWS G I+ LL G F K+I + + +P+ L Sbjct: 196 DIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFY-TPQYL----------------- 237 Query: 265 MPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ----YHDPEDEPEA 320 NP I LL ML +D +R S + H +F Q Y PED P Sbjct: 238 -------------NPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYLFPED-PSY 283 Query: 321 EPYDESVEAKERTLEEWKELTYQEVLS 347 EA + E++ E + +EVLS Sbjct: 284 STTMIDDEALKEVCEKF-ECSEEEVLS 309 >3KN6-A nrPDB Length = 325 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 69/251 (27%), Positives = 124/251 (49%), Gaps = 29/251 (11%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK-HENVIGL 86 +P+G G++ + Q AVK +S+ ++ T +E+ LK + H N++ L Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEA-----NTQKEITALKLCEGHPNIVKL 71 Query: 87 LDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSA 144 +VF D +LV L+ G I K + S+ +++ +L+ + ++H Sbjct: 72 HEVF------HDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDV 125 Query: 145 GIIHRDLKPSNVAV---NEDCELRILDFGLARQA---DEEMTGYVATRWYRAPEIMLNWM 198 G++HRDLKP N+ N++ E++I+DFG AR ++ + T Y APE +LN Sbjct: 126 GVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE-LLNQN 184 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSD-------YIDQLKRIMEVVGTPSPEVLAKIS 251 Y+++ D+WS+G I+ +L G+ F D ++ +K+I + + E +S Sbjct: 185 GYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVS 244 Query: 252 SEHARTYIQSL 262 E A+ IQ L Sbjct: 245 QE-AKDLIQGL 254 >3F3Z-A nrPDB Length = 277 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 79/288 (27%), Positives = 130/288 (45%), Gaps = 44/288 (15%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G G++G V A R + A KK+ + F + R +E+ ++K L H N+I L + Sbjct: 17 IGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVD--RFKQEIEIMKSLDHPNIIRLYET 74 Query: 90 FTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 F ED +++YLV L G +V + + ++ +L + Y H + Sbjct: 75 F------EDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNVA 128 Query: 148 HRDLKPSN---VAVNEDCELRILDFGLAR--QADEEMTGYVATRWYRAPEIMLNWMHYNQ 202 HRDLKP N + + D L+++DFGLA + + M V T +Y +P+++ Y Sbjct: 129 HRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEGL--YGP 186 Query: 203 TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSL 262 D WS G +M LL G F EV+ KI E T+ Sbjct: 187 ECDEWSAGVMMYVLLCGYPPFSAPT---------------DSEVMLKI-REGTFTF---- 226 Query: 263 PPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 P+KD ++ +P A L+ R+L QR+++ +AL H +F + Sbjct: 227 ---PEKDWLNV----SPQAESLIRRLLTKSPKQRITSLQALEHEWFEK 267 >2J90-A nrPDB Length = 304 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 85/296 (28%), Positives = 136/296 (45%), Gaps = 58/296 (19%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPF---QSLIHARRTY------RELRLLKHLKH 80 +GSG + V + RQK K+ + F + L +RR RE+ +L+ ++H Sbjct: 34 LGSGQFAIV-----RKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRH 88 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV--KCQALSDEHVQFLVYQLLRGL 138 N+I L D+F T + V ++ + G +L + + K DE QFL Q+L G+ Sbjct: 89 PNIITLHDIFENKTDV-----VLILELVSGGELFDFLAEKESLTEDEATQFL-KQILDGV 142 Query: 139 KYIHSAGIIHRDLKPSNVAVNE----DCELRILDFGLAR--QADEEMTGYVATRWYRAPE 192 Y+HS I H DLKP N+ + + + ++++DFG+A +A E T + APE Sbjct: 143 HYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPE 202 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 I +N+ D+WS+G I LL G + F +G E L IS Sbjct: 203 I-VNYEPLGLEADMWSIGVITYILLSGASPF---------------LGETKQETLTNIS- 245 Query: 253 EHARTYIQSLPPMPQKDLS-SIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 A Y D F + LA D + R+LV D +R++ A++L H++ Sbjct: 246 --AVNY----------DFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSW 289 >1PHK-A nrPDB Length = 298 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 76/257 (29%), Positives = 119/257 (46%), Gaps = 49/257 (19%) Query: 68 TYRELRLLKHLK-HENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSD 124 T +E+ +L+ + H N+I L D + T +LV LM G + + + LS+ Sbjct: 70 TLKEVDILRKVSGHPNIIQLKDTYETNTFF------FLVFDLMKKGELFDYLTEKVTLSE 123 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD--EEMTGY 182 + + ++ LL + +H I+HRDLKP N+ +++D +++ DFG + Q D E++ Sbjct: 124 KETRKIMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREV 183 Query: 183 VATRWYRAPEIM---LNWMH--YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME 237 T Y APEI+ +N H Y + VD+WS G IM LL G F + L+ IM Sbjct: 184 CGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMS 243 Query: 238 ---VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSD 294 G+P + D S + DL+ R LV+ Sbjct: 244 GNYQFGSPEWD-----------------------DYSDTVK-------DLVSRFLVVQPQ 273 Query: 295 QRVSAAEALAHAYFSQY 311 +R +A EALAH +F QY Sbjct: 274 KRYTAEEALAHPFFQQY 290 >3MN3-A nrPDB Length = 271 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 74/288 (25%), Positives = 135/288 (46%), Gaps = 41/288 (14%) Query: 25 QGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR-RTYRELRLLKHLKHENV 83 Q ++ +G G++G V AY QKVA+K +++ + + R RE+ L+ L+H ++ Sbjct: 7 QIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHI 66 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGADL-NNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 I L DV I+ E+ +V G +L + IV+ +S++ + Q++ ++Y H Sbjct: 67 IKLYDV------IKSKDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCH 120 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVATRWYRAPEIMLNWMHY 200 I+HRDLKP N+ ++E ++I DFGL+ + + + Y APE++ ++ Sbjct: 121 RHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYA 180 Query: 201 NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQ 260 VD+WS G I+ +L + F P + IS+ + Sbjct: 181 GPEVDVWSCGVILYVMLCRRLPFDDESI---------------PVLFKNISNG-----VY 220 Query: 261 SLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 +LP + +P A L+ RML+++ R+S E + +F Sbjct: 221 TLP-----------KFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWF 257 >4C0T-A nrPDB Length = 974 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 78/320 (24%), Positives = 140/320 (43%), Gaps = 63/320 (19%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL--KHENVIG 85 + +G G+Y +V A D ++ AVK L + + +I ++ + + + KH + N +G Sbjct: 272 KELGEGSYSTVILATDKITGKQYAVKVLDK--RHIIKEKKV-KYVNIEKHALNRLSNRLG 328 Query: 86 LLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHS 143 ++ ++ + +D +Y V G L I + L++E + Q+L +KY+H Sbjct: 329 VISLYF---TFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHD 385 Query: 144 AGIIHRDLKPSNVAVNEDCELRILDFGLAR------------QADEEMTGYVATRWYRAP 191 G+IHRDLKP N+ +++ ++I DFG AR D +V T Y +P Sbjct: 386 NGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSP 445 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 E++ N + + D+W+ GCI+ +++ GK F ++ ++I + Sbjct: 446 ELLEN-KYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITK-------------- 490 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAI-DLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 L F P I DL+ ++LVL +R + E H +F Sbjct: 491 ------------------LQFAFSAGFPTIIRDLIKKILVLQPSRRATIPEIQKHYFFQS 532 Query: 311 --YHDPE-----DEPEAEPY 323 + D + D PE PY Sbjct: 533 VDFKDFDSIWLSDPPEIGPY 552 >5F9E-A nrPDB Length = 353 Score = 90.9 bits (224), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 59/204 (28%), Positives = 102/204 (50%), Gaps = 12/204 (5%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH-ARRTYRELRLLK-HLKHENVIGLL 87 +G G++G V A + Q A+K L + + T E R+L +H + + Sbjct: 27 LGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMF 86 Query: 88 DVFTPATSIEDFSEVYLVTTLMGADLN-NIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 F ++ +++ L G DL +I C F +++ GL+++HS GI Sbjct: 87 CTFQTKENL-----FFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGI 141 Query: 147 IHRDLKPSNVAVNEDCELRILDFGLARQ---ADEEMTGYVATRWYRAPEIMLNWMHYNQT 203 ++RDLK N+ +++D ++I DFG+ ++ D + + T Y APEI+L YN + Sbjct: 142 VYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLG-QKYNHS 200 Query: 204 VDIWSVGCIMAELLQGKALFPGSD 227 VD WS G ++ E+L G++ F G D Sbjct: 201 VDWWSFGVLLYEMLIGQSPFHGQD 224 >1U5R-A nrPDB Length = 348 Score = 90.9 bits (224), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 72/254 (28%), Positives = 131/254 (51%), Gaps = 17/254 (6%) Query: 21 PQRL-QGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPF-QSLIHARRTYRELRLLKHL 78 P++L LR +G G++G+V A D R + VA+KK+S QS + +E+R L+ L Sbjct: 52 PEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL 111 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGA--DLNNIVKCQALSDEHVQFLVYQLLR 136 +H N I + + + + ++ +G+ DL + K + L + + + + L+ Sbjct: 112 RHPNTIQYRGCY-----LREHTAWLVMEYCLGSASDLLEVHK-KPLQEVEIAAVTHGALQ 165 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIML- 195 GL Y+HS +IHRD+K N+ ++E +++ DFG A +V T ++ APE++L Sbjct: 166 GLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIM-APANSFVGTPYWMAPEVILA 224 Query: 196 -NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH 254 + Y+ VD+WS+G EL + K P ++ + + + SP + + SE+ Sbjct: 225 MDEGQYDGKVDVWSLGITCIELAERK---PPLFNMNAMSALYHIAQNESPALQSGHWSEY 281 Query: 255 ARTYIQS-LPPMPQ 267 R ++ S L +PQ Sbjct: 282 FRNFVDSCLQKIPQ 295 >5U6Y-A nrPDB Length = 461 Score = 90.5 bits (223), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 80/295 (27%), Positives = 129/295 (43%), Gaps = 44/295 (14%) Query: 25 QGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVI 84 Q +G GA+ V Q+ A K ++ S ++ RE R+ + LKH N++ Sbjct: 3 QLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIV 62 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 L D SI + YL+ L+ G +IV + S+ + Q+L + + H Sbjct: 63 RLHD------SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 116 Query: 143 SAGIIHRDLKPSNVAVN---EDCELRILDFGLARQADEEMT---GYVATRWYRAPEIMLN 196 G++HRDLKP N+ + + +++ DFGLA + + E G+ T Y +PE+ L Sbjct: 117 QMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV-LR 175 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME-VVGTPSPEVLAKISSEHA 255 Y + VD+W+ G I+ LL G F D ++I PSPE Sbjct: 176 KDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPE---------- 225 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + P A DL+ +ML ++ +R++AAEAL H + S Sbjct: 226 ------------------WDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISH 262 >3HKO-A nrPDB Length = 345 Score = 90.5 bits (223), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 92/368 (25%), Positives = 151/368 (41%), Gaps = 92/368 (25%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 61 S R Y Q ++ E+ ++ +G G+YG V A + + R A+K +++ Sbjct: 8 SSGRENLYFQ--GGSLLELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIR 65 Query: 62 LIHAR---RTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADL---- 113 I+ + R E+RL+K L H N+ L +V+ ED + LV L G L Sbjct: 66 QINPKDVERIKTEVRLMKKLHHPNIARLYEVY------EDEQYICLVMELCHGGHLLDKL 119 Query: 114 -----------------NNIVKCQALSDEHVQFLVY--------------------QLLR 136 I C ++E + ++ Q+ Sbjct: 120 NVFIDDSTGKCAMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFS 179 Query: 137 GLKYIHSAGIIHRDLKPSN--VAVNEDCELRILDFGLARQADE-------EMTGYVATRW 187 L Y+H+ GI HRD+KP N + N+ E++++DFGL+++ + MT T + Sbjct: 180 ALHYLHNQGICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPY 239 Query: 188 YRAPEIMLNWMH--YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245 + APE+ LN + Y D WS G ++ LL G FPG + D + +++ Sbjct: 240 FVAPEV-LNTTNESYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLN-------- 290 Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAH 305 K+ E+ + S PLA DLL +L + D+R A AL H Sbjct: 291 --KKLCFENPNYNVLS-----------------PLARDLLSNLLNRNVDERFDAMRALQH 331 Query: 306 AYFSQYHD 313 + SQ+ D Sbjct: 332 PWISQFSD 339 >2YAB-A nrPDB Length = 361 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 84/310 (27%), Positives = 142/310 (45%), Gaps = 50/310 (16%) Query: 30 VGSGAYGSV--CSAYDARLR--QKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIG 85 +GSG + V C L K K+ SR + + RE+ +L+ + H N+I Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNIIT 79 Query: 86 LLDVFTPATSIEDFSEVYLVTTLMGADLNN-IVKCQALSDEHVQFLVYQLLRGLKYIHSA 144 L DV+ T + V ++ + G +L + + + ++LS+E + Q+L G+ Y+H+ Sbjct: 80 LHDVYENRTDV-----VLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTK 134 Query: 145 GIIHRDLKPSNVAVNEDC----ELRILDFGLARQADE--EMTGYVATRWYRAPEIMLNWM 198 I H DLKP N+ + + ++++DFGLA + ++ E T + APEI+ N+ Sbjct: 135 KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIV-NYE 193 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 D+WS+G I LL G + F +G E LA I+ A +Y Sbjct: 194 PLGLEADMWSIGVITYILLSGASPF---------------LGDTKQETLANIT---AVSY 235 Query: 259 IQSLPPMPQKDLS-SIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDE 317 D F + LA D + ++LV ++ +R++ EAL H + + P D Sbjct: 236 ----------DFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT----PVDT 281 Query: 318 PEAEPYDESV 327 +A ESV Sbjct: 282 QQAMVRRESV 291 >2VZ6-A nrPDB Length = 313 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 80/295 (27%), Positives = 129/295 (43%), Gaps = 44/295 (14%) Query: 25 QGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVI 84 Q +G GA+ V Q+ A K ++ S ++ RE R+ + LKH N++ Sbjct: 25 QLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIV 84 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 L D SI + YL+ L+ G +IV + S+ + Q+L + + H Sbjct: 85 RLHD------SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 138 Query: 143 SAGIIHRDLKPSNVAVN---EDCELRILDFGLARQADEEMT---GYVATRWYRAPEIMLN 196 G++HRDLKP N+ + + +++ DFGLA + + E G+ T Y +PE+ L Sbjct: 139 QMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV-LR 197 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME-VVGTPSPEVLAKISSEHA 255 Y + VD+W+ G I+ LL G F D ++I PSPE Sbjct: 198 KDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPE---------- 247 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + P A DL+ +ML ++ +R++AAEAL H + S Sbjct: 248 ------------------WDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISH 284 >2GCD-A nrPDB Length = 309 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 73/252 (28%), Positives = 128/252 (50%), Gaps = 13/252 (5%) Query: 21 PQRL-QGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPF-QSLIHARRTYRELRLLKHL 78 P++L LR +G G++G+V A D R + VA+KK+S QS + +E+R L+ L Sbjct: 13 PEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL 72 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGL 138 +H N I + + E L + +DL + K + L + + + + L+GL Sbjct: 73 RHPNTIQYRGCYLREHTAWLVMEYCLGS---ASDLLEVHK-KPLQEVEIAAVTHGALQGL 128 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIML--N 196 Y+HS +IHRD+K N+ ++E +++ DFG A +V T ++ APE++L + Sbjct: 129 AYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIM-APANSFVGTPYWMAPEVILAMD 187 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHAR 256 Y+ VD+WS+G EL + K P ++ + + + SP + + SE+ R Sbjct: 188 EGQYDGKVDVWSLGITCIELAERK---PPLFNMNAMSALYHIAQNESPALQSGHWSEYFR 244 Query: 257 TYIQS-LPPMPQ 267 ++ S L +PQ Sbjct: 245 NFVDSCLQKIPQ 256 >2V7O-A nrPDB Length = 336 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 81/295 (27%), Positives = 129/295 (43%), Gaps = 44/295 (14%) Query: 25 QGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVI 84 Q +G GA+ V Q+ A K ++ S ++ RE R+ + LKH N++ Sbjct: 34 QLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIV 93 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 L D SI + YLV L+ G +IV + S+ ++Q+L + +IH Sbjct: 94 RLHD------SISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIH 147 Query: 143 SAGIIHRDLKPSNVAVNEDCE---LRILDFGLARQADEEMT---GYVATRWYRAPEIMLN 196 I+HRDLKP N+ + C+ +++ DFGLA + E G+ T Y +PE+ L Sbjct: 148 QHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEV-LR 206 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME-VVGTPSPEVLAKISSEHA 255 Y + VDIW+ G I+ LL G F D ++I PSPE Sbjct: 207 KDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPE---------- 256 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + P A +L+ +ML ++ +R++A +AL H + Q Sbjct: 257 ------------------WDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQ 293 >3GUB-A nrPDB Length = 295 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 82/306 (26%), Positives = 139/306 (45%), Gaps = 56/306 (18%) Query: 30 VGSGAYGSV--CSAYDARLR--QKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIG 85 +GSG + V C L+ K K+ ++ + + RE+ +LK ++H NVI Sbjct: 19 LGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVIT 78 Query: 86 LLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHS 143 L +V+ E+ ++V L+ L+ G + + + ++L++E + Q+L G+ Y+HS Sbjct: 79 LHEVY------ENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHS 132 Query: 144 AGIIHRDLKPSNVAVNEDC----ELRILDFGLARQAD--EEMTGYVATRWYRAPEIMLNW 197 I H DLKP N+ + + ++I+DFGLA + D E T + APEI +N+ Sbjct: 133 LQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEI-VNY 191 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS---EH 254 D+WS+G I LL G + F +G E LA +S+ E Sbjct: 192 EPLGLEADMWSIGVITYILLSGASPF---------------LGDTKQETLANVSAVNYEF 236 Query: 255 ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 314 Y F + LA D + R+LV D +R++ ++L H + P Sbjct: 237 EDEY---------------FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIK----P 277 Query: 315 EDEPEA 320 +D +A Sbjct: 278 KDTQQA 283 >4OW8-A nrPDB Length = 283 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 70/222 (31%), Positives = 107/222 (48%), Gaps = 10/222 (4%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR-ELRLLKHLKHE 81 RLQ R + +G G V A D RL ++VAVK L F S +R E R L H Sbjct: 14 RLQ--RLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 71 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-LSDEHVQFLVYQLLRGLKY 140 + + D + E + ++ + G LN+++K LS H ++ Q R L+ Sbjct: 72 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 131 Query: 141 IHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE---EMTGYV-ATRWYRAPEIMLN 196 H+AG++HRD+KP N+ + +++I DFG+A+ D TG V T Y APE L Sbjct: 132 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 191 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID-QLKRIME 237 + D++S+G + E + GK F G + +K I E Sbjct: 192 H-DASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKE 232 >4YNZ-A nrPDB Length = 342 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 87/305 (28%), Positives = 142/305 (46%), Gaps = 46/305 (15%) Query: 21 PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKH 80 P RL+ + +G G G V QKVA+K ++R S + RE+ +LK ++H Sbjct: 11 PYRLE--KTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEH 68 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTT-LMGADL-NNIVKCQALSDEHVQFLVYQLLRGL 138 +V+ L DV+ E+ +YLV + G +L + +VK L+ + + Q++ L Sbjct: 69 PHVLKLHDVY------ENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 122 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLA--RQADEEMTGYVATRWYRAPEIMLN 196 + HS I HRDLKP N+ ++E +RI DFG+A + D + + Y PE++ Sbjct: 123 DFCHSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRG 182 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHAR 256 + + D+WS G I+ LL G P D D L++++E V K H Sbjct: 183 EKYDGRKADVWSCGVILFALLVGA--LPFDD--DNLRQLLEKV---------KRGVFHMP 229 Query: 257 TYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPED 316 +I PP D S+ RG M+ +D+ +R++ H + Y ++ Sbjct: 230 HFI---PP----DCQSLLRG-----------MIEVDAARRLTLEHIQKHIW---YIGGKN 268 Query: 317 EPEAE 321 EPE E Sbjct: 269 EPEPE 273 >4X3F-A nrPDB Length = 337 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 74/223 (33%), Positives = 109/223 (48%), Gaps = 12/223 (5%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR-ELRLLKHLKHE 81 RLQ R + +G G V A D RL ++VAVK L F S +R E R L H Sbjct: 15 RLQ--RLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 72 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA-LSDEHVQFLVYQLLRGLK 139 + + D + E + YLV L+ G LN+++K LS H ++ Q R L+ Sbjct: 73 GIASVHDYGESQMNGEGRT-AYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 131 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE---EMTGYV-ATRWYRAPEIML 195 H+AG++HRD+KP N+ + +++I DFG+A+ D TG V T Y APE L Sbjct: 132 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 191 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID-QLKRIME 237 + D++S+G + E + GK F G + +K I E Sbjct: 192 GH-DASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKE 233 >4FR4-A nrPDB Length = 384 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 57/203 (28%), Positives = 108/203 (53%), Gaps = 17/203 (8%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH---ARRTYRELRLLKHLKHENV 83 LR +G G++G VC ++ A+K +++ Q + R ++EL++++ L+H + Sbjct: 20 LRAIGKGSFGKVCIVQKNDTKKMYAMKYMNK--QKCVERNEVRNVFKELQIMQGLEHPFL 77 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLM-GADLN-NIVKCQALSDEHVQFLVYQLLRGLKYI 141 + L S +D ++++V L+ G DL ++ + +E V+ + +L+ L Y+ Sbjct: 78 VNLW------YSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYL 131 Query: 142 HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--DEEMTGYVATRWYRAPEIMLN--W 197 + IIHRD+KP N+ ++E + I DF +A + ++T T+ Y APE+ + Sbjct: 132 QNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKG 191 Query: 198 MHYNQTVDIWSVGCIMAELLQGK 220 Y+ VD WS+G ELL+G+ Sbjct: 192 AGYSFAVDWWSLGVTAYELLRGR 214 >3BHH-A nrPDB Length = 295 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 81/290 (27%), Positives = 129/290 (44%), Gaps = 44/290 (15%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G GA+ V + A K ++ S ++ RE R+ + LKH N++ L D Sbjct: 12 IGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHD- 70 Query: 90 FTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 + S E F YLV L+ G +IV + S+ + Q+L + + H G++ Sbjct: 71 ---SISEEGFH--YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 125 Query: 148 HRDLKPSNVAVNEDCE---LRILDFGLA--RQADEEM-TGYVATRWYRAPEIMLNWMHYN 201 HRDLKP N+ + C+ +++ DFGLA Q D++ G+ T Y +PE+ L Y Sbjct: 126 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV-LRKEAYG 184 Query: 202 QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME-VVGTPSPEVLAKISSEHARTYIQ 260 + VDIW+ G I+ LL G F D ++I PSPE Sbjct: 185 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPE--------------- 229 Query: 261 SLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + P A +L+ +ML ++ +R++A EAL H + Q Sbjct: 230 -------------WDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQ 266 >2VN9-A nrPDB Length = 301 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 83/295 (28%), Positives = 132/295 (44%), Gaps = 44/295 (14%) Query: 25 QGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVI 84 Q +G GA+ V Q+ A K ++ S ++ RE R+ + LKH N++ Sbjct: 7 QLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIV 66 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 L D + S E F YLV L+ G +IV + S+ + Q+L + + H Sbjct: 67 RLHD----SISEEGFH--YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 120 Query: 143 SAGIIHRDLKPSNVAV---NEDCELRILDFGLA--RQADEEM-TGYVATRWYRAPEIMLN 196 GI+HRDLKP N+ + ++ +++ DFGLA Q D++ G+ T Y +PE+ L Sbjct: 121 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV-LR 179 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME-VVGTPSPEVLAKISSEHA 255 Y + VD+W+ G I+ LL G F D ++I PSPE Sbjct: 180 KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPE---------- 229 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + P A DL+ +ML ++ +R++A+EAL H + Q Sbjct: 230 ------------------WDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQ 266 >6B2Q-A nrPDB Length = 317 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 70/222 (31%), Positives = 107/222 (48%), Gaps = 10/222 (4%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR-ELRLLKHLKHE 81 RLQ R + +G G V A D RL ++VAVK L F S +R E R L H Sbjct: 35 RLQ--RLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 92 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-LSDEHVQFLVYQLLRGLKY 140 + + D + E + ++ + G LN+++K LS H ++ Q R L+ Sbjct: 93 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 152 Query: 141 IHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE---EMTGYV-ATRWYRAPEIMLN 196 H+AG++HRD+KP N+ + +++I DFG+A+ D TG V T Y APE L Sbjct: 153 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 212 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID-QLKRIME 237 + D++S+G + E + GK F G + +K I E Sbjct: 213 H-DASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKE 253 >1ZXE-A nrPDB Length = 303 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 63/236 (26%), Positives = 115/236 (48%), Gaps = 32/236 (13%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL-- 87 +G GA+G V A +A + A+KK+ + L E+ LL L H+ V+ Sbjct: 14 LGQGAFGQVVKARNALDSRYYAIKKIRHTEEKL---STILSEVMLLASLNHQYVVRYYAA 70 Query: 88 -----DVFTPATSIEDFSEVYL-VTTLMGADLNNIVKCQALSDEHVQF--LVYQLLRGLK 139 + P T+++ S +++ + L +++ + L+ + ++ L Q+L L Sbjct: 71 WLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQILEALS 130 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ-----------------ADEEMTGY 182 YIHS GIIHR+LKP N+ ++E ++I DFGLA+ + + +T Sbjct: 131 YIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNLTSA 190 Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 238 + T Y A E++ HYN+ +D++S+G I E++ G + ++ LK++ V Sbjct: 191 IGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY--PFSTGMERVNILKKLRSV 244 >5YV8-A nrPDB Length = 298 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 79/311 (25%), Positives = 142/311 (45%), Gaps = 63/311 (20%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRP--------------------FQSLIHAR--- 66 +G G+YG V AY+ A+K LS+ I R Sbjct: 21 IGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPI 80 Query: 67 -RTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSD 124 + Y+E+ +LK L H NV+ L++V ED +Y+V L+ + + + LS+ Sbjct: 81 EQVYQEIAILKKLDHPNVVKLVEVLDDPN--ED--HLYMVFELVNQGPVMEVPTLKPLSE 136 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ---ADEEMTG 181 + +F L++G++Y+H IIHRD+KPSN+ V ED ++I DFG++ + +D ++ Sbjct: 137 DQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSN 196 Query: 182 YVATRWYRAPEIM--LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVV 239 V T + APE + + + +D+W++G + + G+ F +D+ RIM + Sbjct: 197 TVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF-----MDE--RIMCL- 248 Query: 240 GTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSA 299 H++ Q+L Q D++ + DL+ RML + + R+ Sbjct: 249 --------------HSKIKSQALEFPDQPDIAEDLK-------DLITRMLDKNPESRIVV 287 Query: 300 AEALAHAYFSQ 310 E H + ++ Sbjct: 288 PEIKLHPWVTR 298 >5FG8-A nrPDB Length = 285 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 79/271 (29%), Positives = 124/271 (45%), Gaps = 51/271 (18%) Query: 50 VAVKKLS-RPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTL 108 + KKL+ R FQ L RE R+ + L H N++ L D SI++ + YLV L Sbjct: 47 INTKKLTARDFQKL------EREARICRKLHHPNIVRLHD------SIQEENYHYLVFDL 94 Query: 109 M--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE--- 163 + G +IV + S+ + Q+L + + H G++HRDLKP N+ + + Sbjct: 95 VTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAA 154 Query: 164 LRILDFGLA--RQADEEM-TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGK 220 +++ DFGLA Q D + G+ T Y +PE+ L Y ++VDIW+ G I+ LL G Sbjct: 155 VKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEV-LKKEPYGKSVDIWACGVILYILLVGY 213 Query: 221 ALFPGSDYIDQLKRIME-VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANP 279 F D +I PSPE + P Sbjct: 214 PPFWDEDQHRLYSQIKAGAYDYPSPE----------------------------WDTVTP 245 Query: 280 LAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 A +L+ +ML ++ ++R++AAEAL H + Q Sbjct: 246 EAKNLINQMLTVNPNKRITAAEALKHPWICQ 276 >5UNP-A nrPDB Length = 369 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 81/328 (24%), Positives = 138/328 (42%), Gaps = 46/328 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 +R + + +G G +G V D R K+ + + A R E+ +L+ + + Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARL--EINVLEKINEK 91 Query: 82 N------VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLL 135 + + + D F + E+ ++T NN + V+ + +QL Sbjct: 92 DPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYL---PYPIHQVRHMAFQLC 148 Query: 136 RGLKYIHSAGIIHRDLKPSNVA-VNEDCEL------------------RILDFGLARQAD 176 + +K++H + H DLKP N+ VN D EL R++DFG A Sbjct: 149 QAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDH 208 Query: 177 EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 E + V+TR YRAPE++L + ++Q D+WS+GCI+ E G LF D + L +M Sbjct: 209 EHHSTIVSTRHYRAPEVILE-LGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLA-MM 266 Query: 237 EVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFR-GANPLA-------------I 282 E + P P + + + + Y L R PL Sbjct: 267 ERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLF 326 Query: 283 DLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 DL+ ML + +R++ EAL H +F++ Sbjct: 327 DLIESMLEYEPAKRLTLGEALQHPFFAR 354 >2XNP-A nrPDB Length = 279 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 70/213 (32%), Positives = 111/213 (52%), Gaps = 24/213 (11%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAV-KKLSRPFQSLIHARRTYRELRLLKHLKHENVIG 85 L +G+G+YG C + K+ V K+L + + E+ LL+ LKH N++ Sbjct: 11 LYTIGTGSYGR-CQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVR 69 Query: 86 LLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV-----KCQALSDEHVQFLVYQLLRGLK 139 D T+ + +Y+V G DL +++ + Q L +E V ++ QL LK Sbjct: 70 YYDRIIDRTN----TTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125 Query: 140 YIH--SAG---IIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT---GYVATRWYRAP 191 H S G ++HRDLKP+NV ++ +++ DFGLAR + + + +V T +Y +P Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFP 224 E M N M YN+ DIWS+GC++ EL AL P Sbjct: 186 EQM-NRMSYNEKSDIWSLGCLLYELC---ALMP 214 >6CCF-A nrPDB Length = 290 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 62/199 (31%), Positives = 105/199 (52%), Gaps = 16/199 (8%) Query: 58 PFQSLIHARRTYRELRLLKHLKHENVIGLLDVFT-PATSIEDFSEVYLVTTLMGADLNNI 116 P + L+ R Y+E+ +LK L H NV+ L++V PA ED +YLV L+ Sbjct: 65 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPA---ED--NLYLVFDLLRKGPVME 119 Query: 117 VKC-QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ- 174 V C + S+E + + ++ GL+Y+H I+HRD+KPSN+ + +D ++I DFG++ Q Sbjct: 120 VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 179 Query: 175 --ADEEMTGYVATRWYRAPEIMLN--WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID 230 D +++ T + APE + + + +D+W+ G + + GK F D+I Sbjct: 180 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFI-DDFIL 238 Query: 231 QLKRIME---VVGTPSPEV 246 L R ++ VV PE+ Sbjct: 239 ALHRKIKNEPVVFPEEPEI 257 >6FDY-U nrPDB Length = 276 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 83/304 (27%), Positives = 133/304 (43%), Gaps = 45/304 (14%) Query: 21 PQRLQGL---RPVGSGAYGSVCSAYDAR-LRQKVAVKKLSRPFQSLIHARRTYRELRLLK 76 P RL G +GSG Y +V AY + R+ VA+K +++ + E+ +LK Sbjct: 7 PPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILK 66 Query: 77 HLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHV-QFLVYQL 134 ++H +++ L D D +YL+ G DL+ + + + E V + + QL Sbjct: 67 GIRHPHIVQLKDFQW------DSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQL 120 Query: 135 LRGLKYIHSAGIIHRDLKPSNVAVN--EDCELRILDFGLARQAD--EEMTGYVATRWYRA 190 L+++H I H DLKP N+ ++ E L++ DFG A+ +E + Y A Sbjct: 121 ASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMA 180 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI 250 PE M+ Y+ VD+WS+G I+ E L G+ F + E+ KI Sbjct: 181 PE-MVCQRQYDARVDLWSMGVILYEALFGQPPFASRSF---------------SELEEKI 224 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 S R L P+ +D DLL R+L D +R+S + AH + Sbjct: 225 RSN--RVIELPLRPLLSRDCR-----------DLLQRLLERDPSRRISFQDFFAHPWVDL 271 Query: 311 YHDP 314 H P Sbjct: 272 EHMP 275 >5ES1-A nrPDB Length = 328 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 55/214 (25%), Positives = 105/214 (49%), Gaps = 10/214 (4%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 LR +G G + V A ++VA+K + + + ++ +RE+R++K L H N++ L Sbjct: 20 LRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKL 79 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGAD--LNNIVKCQALSDEHVQFLVYQLLRGLKYIHSA 144 +V IE +YLV A + +V + ++ + Q++ + Y H Sbjct: 80 FEV------IETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQK 133 Query: 145 GIIHRDLKPSNVAVNEDCELRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWMHYNQ 202 I+HRDLK N+ ++ + ++I DFG + + ++ + + Y APE+ + Sbjct: 134 NIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGP 193 Query: 203 TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 VDIWS+G I+ L+ G F G + + +R++ Sbjct: 194 EVDIWSLGVILYTLVSGSLPFDGHNLKELRERVL 227 >3DAK-A nrPDB Length = 290 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 81/300 (27%), Positives = 134/300 (44%), Gaps = 48/300 (16%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +GSGA V +AY A ++KVA+K+++ + +E++ + H N++ Sbjct: 18 IGSGATAVVQAAYCAPKKEKVAIKRINLE-KCQTSMDELLKEIQAMSQCHHPNIVSYYTS 76 Query: 90 FTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEH---------VQFLVYQLLRGLK 139 F ++D E++LV L+ G + +I+K EH + ++ ++L GL+ Sbjct: 77 FV----VKD--ELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLE 130 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFG----LARQAD----EEMTGYVATRWYRAP 191 Y+H G IHRD+K N+ + ED ++I DFG LA D + +V T + AP Sbjct: 131 YLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAP 190 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI- 250 E+M Y+ DIWS G EL G A P Y +K +M + P + + Sbjct: 191 EVMEQVRGYDFKADIWSFGITAIELATGAA--PYHKY-PPMKVLMLTLQNDPPSLETGVQ 247 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 E + Y +S M + L D ++R +AAE L H +F + Sbjct: 248 DKEMLKKYGKSFRKM-------------------ISLCLQKDPEKRPTAAELLRHKFFQK 288 >5D7A-A nrPDB Length = 308 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 61/243 (25%), Positives = 116/243 (47%), Gaps = 16/243 (6%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 VG+G YG V + Q A+K + ++ L+ H H N+ Sbjct: 25 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH--HRNIATYYGA 82 Query: 90 FTPATSIEDFSEVYLVTTLMGA----DLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAG 145 F +++LV GA DL K L +E + ++ ++LRGL ++H Sbjct: 83 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHK 142 Query: 146 IIHRDLKPSNVAVNEDCELRILDFGLARQADEEM---TGYVATRWYRAPEIMLNWMH--- 199 +IHRD+K NV + E+ E++++DFG++ Q D + ++ T ++ APE++ + Sbjct: 143 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 202 Query: 200 -YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 Y+ D+WS+G E+ +G P D + ++ + + P+P + +K S+ +++ Sbjct: 203 TYDFKSDLWSLGITAIEMAEGAP--PLCD-MHPMRALFLIPRNPAPRLKSKKWSKKFQSF 259 Query: 259 IQS 261 I+S Sbjct: 260 IES 262 >6C9D-A nrPDB Length = 459 Score = 87.4 bits (215), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 57/218 (26%), Positives = 108/218 (49%), Gaps = 12/218 (5%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 RLQ + +G G + V A ++VAVK + + + ++ +RE+R++K L H N Sbjct: 24 RLQ--KTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 81 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKY 140 ++ L +V IE +YLV G + +V + ++ + Q++ ++Y Sbjct: 82 IVKLFEV------IETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 135 Query: 141 IHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWM 198 H I+HRDLK N+ ++ D ++I DFG + + ++ + + Y APE+ Sbjct: 136 CHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKK 195 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 + VD+WS+G I+ L+ G F G + + +R++ Sbjct: 196 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVL 233 >4I6B-A nrPDB Length = 308 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 70/260 (26%), Positives = 121/260 (46%), Gaps = 15/260 (5%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR-RTYRELRLLKHLKH 80 +R + +G G + D + A K + S H R + +E+ L + L H Sbjct: 28 KRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHH 87 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVKC-QALSDEHVQFLVYQLLRGL 138 ++V+ F ED +Y++ + +I+K + L++ V++ + Q++ GL Sbjct: 88 KHVVQFYHYF------EDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGL 141 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ---ADEEMTGYVATRWYRAPEIML 195 KY+H I+HRDLK N +NE EL++ DFGLA + + T Y +PE+ L Sbjct: 142 KYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEV-L 200 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 N + DIW++GC+M +L G+ F ++ + + I E T +LA ++H Sbjct: 201 NKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLA--PAKHL 258 Query: 256 RTYIQSLPPMPQKDLSSIFR 275 + S P + L I R Sbjct: 259 IASMLSKNPEDRPSLDDIIR 278 >2HAK-A nrPDB Length = 328 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 57/218 (26%), Positives = 108/218 (49%), Gaps = 12/218 (5%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 RLQ + +G G + V A ++VAVK + + + ++ +RE+R++K L H N Sbjct: 18 RLQ--KTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 75 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKY 140 ++ L +V IE +YLV G + +V + ++ + Q++ ++Y Sbjct: 76 IVKLFEV------IETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 129 Query: 141 IHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWM 198 H I+HRDLK N+ ++ D ++I DFG + + ++ + + Y APE+ Sbjct: 130 CHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKK 189 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 + VD+WS+G I+ L+ G F G + + +R++ Sbjct: 190 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVL 227 >3SOA-A nrPDB Length = 444 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 79/304 (25%), Positives = 130/304 (42%), Gaps = 44/304 (14%) Query: 16 TVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLL 75 T + Q +G GA+ V Q+ A ++ S ++ RE R+ Sbjct: 5 TCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARIC 64 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQ 133 + LKH N++ L D SI + YL+ L+ G +IV + S+ + Q Sbjct: 65 RLLKHPNIVRLHD------SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQ 118 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVN---EDCELRILDFGLARQADEEMT---GYVATRW 187 +L + + H G++HR+LKP N+ + + +++ DFGLA + + E G+ T Sbjct: 119 ILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPG 178 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME-VVGTPSPEV 246 Y +PE+ L Y + VD+W+ G I+ LL G F D ++I PSPE Sbjct: 179 YLSPEV-LRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPE- 236 Query: 247 LAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHA 306 + P A DL+ +ML ++ +R++AAEAL H Sbjct: 237 ---------------------------WDTVTPEAKDLINKMLTINPSKRITAAEALKHP 269 Query: 307 YFSQ 310 + S Sbjct: 270 WISH 273 >2X4F-A nrPDB Length = 373 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 74/288 (25%), Positives = 128/288 (44%), Gaps = 41/288 (14%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G G +G V + K+A K + + + E+ ++ L H N+I L D Sbjct: 97 LGGGRFGQVHKCEETATGLKLAAKIIKT--RGMKDKEEVKNEISVMNQLDHANLIQLYDA 154 Query: 90 FTPATSIEDFSEVYLVTTLMGADLNN--IVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 F I V ++ + G +L + I + L++ + Q+ G++++H I+ Sbjct: 155 FESKNDI-----VLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYIL 209 Query: 148 HRDLKPSNV-AVNEDC-ELRILDFGLARQAD--EEMTGYVATRWYRAPEIMLNWMHYNQT 203 H DLKP N+ VN D +++I+DFGLAR+ E++ T + APE+ +N+ + Sbjct: 210 HLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEV-VNYDFVSFP 268 Query: 204 VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLP 263 D+WSVG I LL G + F G + + L I+ E IS E Sbjct: 269 TDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEE---------- 318 Query: 264 PMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 A + + ++L+ + R+SA+EAL H + S + Sbjct: 319 -----------------AKEFISKLLIKEKSWRISASEALKHPWLSDH 349 >4CZT-A nrPDB Length = 464 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 61/226 (26%), Positives = 109/226 (48%), Gaps = 16/226 (7%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR---RTYRELRLLKHLKHENVI 84 R +G G + V A + VA+K + + + ++ + + RE+ +K +KH NVI Sbjct: 17 RTLGEGTFAKVKFARNVENGDNVAIKVIDK--EKVLKNKMIAQIKREISTMKLIKHPNVI 74 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-LSDEHVQFLVYQLLRGLKYIHS 143 + +V T I +++ + G +L + + L ++ + QL+ + Y HS Sbjct: 75 RMFEVMASKTKI-----YFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 129 Query: 144 AGIIHRDLKPSNVAVNEDCELRILDFGLA---RQADEE--MTGYVATRWYRAPEIMLNWM 198 G+ HRDLKP N+ ++ + L++ DFGL+ +Q E+ + T Y APE++ N Sbjct: 130 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 189 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSP 244 + D+WS G I+ L+ G F S+ K+I + T P Sbjct: 190 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP 235 >2JC6-A nrPDB Length = 334 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 62/198 (31%), Positives = 107/198 (54%), Gaps = 17/198 (8%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTY-RELRLLKHLKHENVIGLLD 88 +G+GA+ V A + + AVK + P ++L + E+ +L+ +KHEN++ L D Sbjct: 30 LGTGAFSEVVLAEEKATGKLFAVKCI--PKKALKGKESSIENEIAVLRKIKHENIVALED 87 Query: 89 VFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 ++ E + +YLV L+ G + IV+ +++ L+ Q+L + Y+H GI Sbjct: 88 IY------ESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGI 141 Query: 147 IHRDLKPSNV---AVNEDCELRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWMHYN 201 +HRDLKP N+ + +E+ ++ I DFGL++ + M+ T Y APE++ Y+ Sbjct: 142 VHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQ-KPYS 200 Query: 202 QTVDIWSVGCIMAELLQG 219 + VD WS+G I LL G Sbjct: 201 KAVDCWSIGVIAYILLCG 218 >4CSV-A nrPDB Length = 275 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 68/233 (29%), Positives = 121/233 (51%), Gaps = 29/233 (12%) Query: 18 WEVPQRLQGL-RPVGSGAYGSVCSAYDARLRQ---KVAVKKLSRPFQSLIHARRTYRELR 73 WE+P+ L R +GSG +G V Y+ + R +VAVK L + + +E + Sbjct: 6 WEIPRSEITLERKLGSGQFGEV---YEGKWRNYNIEVAVKTLK---EGTMSVEEFLQEAQ 59 Query: 74 LLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQA--LSDEHVQF 129 ++K LKH N++ L V T I Y++T M G+ L+ + C+ ++ + + Sbjct: 60 IMKKLKHPNLVQLYGVCTKEPPI------YIITEYMSHGSLLDYLRDCEGHTVNAQALLD 113 Query: 130 LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE-EMTGYVATRW- 187 + Q+ G+ Y+ S IHRDL N V E+ +++ DFGLAR +E E T ++ Sbjct: 114 MAAQVASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFP 173 Query: 188 --YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFP---GSDYIDQLKR 234 + APE +++ ++ D+W+ G ++ E+ G+ +P GS+ I+Q++R Sbjct: 174 IKWTAPE-AISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVER 225 >5KZ7-A nrPDB Length = 346 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 55/214 (25%), Positives = 106/214 (49%), Gaps = 10/214 (4%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 L+ +G G + V A ++VAVK + + + ++ +RE+R++K L H N++ L Sbjct: 38 LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKL 97 Query: 87 LDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSA 144 +V IE +YLV G + +V + ++ + Q++ ++Y H Sbjct: 98 FEV------IETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 151 Query: 145 GIIHRDLKPSNVAVNEDCELRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWMHYNQ 202 I+HRDLK N+ ++ D ++I DFG + + ++ + + Y APE+ + Sbjct: 152 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 211 Query: 203 TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 VD+WS+G I+ L+ G F G + + +R++ Sbjct: 212 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVL 245 >3ORZ-A nrPDB Length = 316 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 74/283 (26%), Positives = 129/283 (45%), Gaps = 52/283 (18%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT---YRELRLLKHLKHENVIGL 86 +G G++ +V A + ++ A+K L + + +I + RE ++ L H + L Sbjct: 45 LGEGSFSTVVLARELATSREYAIKILEK--RHIIKENKVPYVTRERDVMSRLDHPFFVKL 102 Query: 87 LDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSA 144 F +D ++Y + G L I K + + +F +++ L+Y+H Sbjct: 103 YFCF------QDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 156 Query: 145 GIIHRDLKPSNVAVNEDCELRILDFGLARQADEE-----MTGYVATRWYRAPEIMLNWMH 199 GIIHRDLKP N+ +NED ++I DFG A+ E +V T Y +PE +L Sbjct: 157 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPE-LLTEKS 215 Query: 200 YNQTVDIWSVGCIMAELLQGKALF-PGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 ++ D+W++GCI+ +L+ G F G++Y+ + KI Sbjct: 216 ACKSSDLWALGCIIYQLVAGLPPFRAGNEYL----------------IFQKI-------- 251 Query: 259 IQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAE 301 I+ P+K P A DL+ ++LVLD+ +R+ E Sbjct: 252 IKLEYDFPEKFF--------PKARDLVEKLLVLDATKRLGCEE 286 >4WB7-A nrPDB Length = 405 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 73/281 (25%), Positives = 125/281 (44%), Gaps = 39/281 (13%) Query: 18 WEVP-------QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTY 69 WE P + + ++ +G+G++G V A+K L + L T Sbjct: 85 WESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTL 144 Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHV 127 E R+L+ + ++ L S +D S +Y+V + G +++ + S+ H Sbjct: 145 NEKRILQAVNFPFLVKL------EFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHA 198 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW 187 +F Q++ +Y+HS +I+RDLKP N+ +++ +++ DFG A++ T Sbjct: 199 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPE 258 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 247 Y APEI+L+ YN+ VD W++G ++ E+ G F + DQ +I E Sbjct: 259 YLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPF----FADQPIQIYE---------- 303 Query: 248 AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRM 288 KI S R P DL + R N L +DL R Sbjct: 304 -KIVSGKVR-----FPSHFSSDLKDLLR--NLLQVDLTKRF 336 >4L42-A nrPDB Length = 346 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 62/228 (27%), Positives = 112/228 (49%), Gaps = 17/228 (7%) Query: 21 PQRLQGLRPVGSGAYGSVC---SAYDARLRQKVAVKKLSRPF--QSLIHARRTYRELRLL 75 P+ + LR +G G YG V A + A+K L + ++ T E +L Sbjct: 17 PECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL 76 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTT-LMGADLNNIVKCQALSDEHVQ-FLVYQ 133 + +KH ++ L+ F ++YL+ L G +L ++ + + E F + + Sbjct: 77 EEVKHPFIVDLIYAFQTG------GKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAE 130 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT---GYVATRWYRA 190 + L ++H GII+RDLKP N+ +N +++ DFGL +++ + T + T Y A Sbjct: 131 ISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMA 190 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 238 PEI++ H N+ VD WS+G +M ++L G F G + + +I++ Sbjct: 191 PEILMRSGH-NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC 237 >2QNJ-A nrPDB Length = 328 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 53/214 (24%), Positives = 106/214 (49%), Gaps = 10/214 (4%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 L+ +G G + V A ++VA+K + + + ++ +RE+R++K L H N++ L Sbjct: 17 LKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKL 76 Query: 87 LDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSA 144 +V IE +YL+ G + +V + ++ + Q++ ++Y H Sbjct: 77 FEV------IETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 130 Query: 145 GIIHRDLKPSNVAVNEDCELRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWMHYNQ 202 I+HRDLK N+ ++ D ++I DFG + + ++ + + Y APE+ + Sbjct: 131 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 190 Query: 203 TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 VD+WS+G I+ L+ G F G + + +R++ Sbjct: 191 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVL 224 >4JXF-A nrPDB Length = 266 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 61/216 (28%), Positives = 111/216 (51%), Gaps = 18/216 (8%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA---RRTYRELRLLKHLKHENVIGL 86 +G G++ V A +VA+K + + +++ A +R E+++ LKH +++ L Sbjct: 15 LGKGSFAGVYRAESIHTGLEVAIKMIDK--KAMYKAGMVQRVQNEVKIHCQLKHPSILEL 72 Query: 87 LDVFTPATSIEDFSEVYLVTTLM-GADLNNIVK--CQALSDEHVQFLVYQLLRGLKYIHS 143 + F ED + VYLV + ++N +K + S+ + ++Q++ G+ Y+HS Sbjct: 73 YNYF------EDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHS 126 Query: 144 AGIIHRDLKPSNVAVNEDCELRILDFGLARQAD---EEMTGYVATRWYRAPEIMLNWMHY 200 GI+HRDL SN+ + + ++I DFGLA Q E+ T Y +PEI H Sbjct: 127 HGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHG 186 Query: 201 NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 ++ D+WS+GC+ LL G+ F + L +++ Sbjct: 187 LES-DVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV 221 >2JAM-A nrPDB Length = 304 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 61/199 (30%), Positives = 103/199 (51%), Gaps = 15/199 (7%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 + +GSGA+ V RL K+ K + + + E+ +LK +KHEN++ L Sbjct: 14 MEVLGSGAFSEVFLV-KQRLTGKLFALKCIKKSPAFRDSSLE-NEIAVLKKIKHENIVTL 71 Query: 87 LDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSA 144 D++ E + YLV L+ G + I++ +++ ++ Q+L +KY+H Sbjct: 72 EDIY------ESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHEN 125 Query: 145 GIIHRDLKPSNVAV---NEDCELRILDFGLAR-QADEEMTGYVATRWYRAPEIMLNWMHY 200 GI+HRDLKP N+ E+ ++ I DFGL++ + + M+ T Y APE++ Y Sbjct: 126 GIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQ-KPY 184 Query: 201 NQTVDIWSVGCIMAELLQG 219 ++ VD WS+G I LL G Sbjct: 185 SKAVDCWSIGVITYILLCG 203 >5X3F-B nrPDB Length = 393 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 73/281 (25%), Positives = 124/281 (44%), Gaps = 39/281 (13%) Query: 18 WEVPQR-------LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTY 69 WE P + ++ +G+G++G V A+K L + L T Sbjct: 73 WETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTL 132 Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHV 127 E R+L+ + ++ L S +D S +Y+V + G +++ + S+ H Sbjct: 133 NEKRILQAVNFPFLVKL------EFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHA 186 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW 187 +F Q++ +Y+HS +I+RDLKP N+ +++ +++ DFG A++ T Sbjct: 187 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPE 246 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 247 Y APEI+L+ YN+ VD W++G ++ E+ G F + DQ +I E Sbjct: 247 YLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPF----FADQPIQIYE---------- 291 Query: 248 AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRM 288 KI S R P DL + R N L +DL R Sbjct: 292 -KIVSGKVR-----FPSHFSSDLKDLLR--NLLQVDLTKRF 324 >1FOT-A nrPDB Length = 318 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 107/218 (49%), Gaps = 8/218 (3%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ-SLIHARRTYRELRLLKHLKH 80 Q Q LR +G+G++G V + A+K L + L T E +L + H Sbjct: 6 QDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTH 65 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV-KCQALSDEHVQFLVYQLLRGLK 139 +I + F A I ++ + G +L +++ K Q + +F ++ L+ Sbjct: 66 PFIIRMWGTFQDAQQI-----FMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALE 120 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMH 199 Y+HS II+RDLKP N+ ++++ ++I DFG A+ + T Y APE+ ++ Sbjct: 121 YLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEV-VSTKP 179 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME 237 YN+++D WS G ++ E+L G F S+ + ++I+ Sbjct: 180 YNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILN 217 >5DYK-A nrPDB Length = 853 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 64/222 (28%), Positives = 118/222 (53%), Gaps = 17/222 (7%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN- 82 L+ R +G G +G+V + + + A+K +S+ +S+I+ + ++L + + EN Sbjct: 541 LETERIIGRGTFGTVKLVHHKPTKIRYALKCVSK--RSIINLNQQ-NNIKLEREITAEND 597 Query: 83 ---VIGLLDVFTPATSIEDFSEVYLVTTLM-GADL-NNIVKCQALSDEHVQFLVYQLLRG 137 +I L+ F +D Y +T L+ G +L + I K LS QF + ++ Sbjct: 598 HPFIIRLVRTF------KDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILA 651 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNW 197 ++Y+H I++RDLKP N+ +++ ++++DFG A++ V T Y APE++L Sbjct: 652 IEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILG- 710 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVV 239 Y TVDIW++G + E + G F G+D DQL+ +++ Sbjct: 711 KGYGCTVDIWALGICLYEFICGPLPF-GNDEEDQLEIFRDIL 751 >5IG1-A nrPDB Length = 344 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 64/224 (28%), Positives = 109/224 (48%), Gaps = 15/224 (6%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G GA+ +V + R + AVK ++ + RE+ + L+HE+++ + Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRRA 84 Query: 90 FTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 F D S YLV + G + IV + +++ ++Q+L L++ HS II Sbjct: 85 F------RDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNII 138 Query: 148 HRDLKPSNVAV---NEDCELRILDFGLARQADEEMT--GYVATRWYRAPEIMLNWMHYNQ 202 HRDLKP N+ + + + ++I DFGLA ++ T G+ T Y +PE+ + + Y+ Sbjct: 139 HRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEV-IRRVPYDT 197 Query: 203 TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV-VGTPSPE 245 VD+W+ G I+ LL G F D+ +I PSPE Sbjct: 198 AVDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPE 241 >4D28-A nrPDB Length = 446 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 103/208 (49%), Gaps = 16/208 (7%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR---RTYRELRLLKHLKHENVI 84 R +G G + V A + VA+K +++ +++ R + RE+ ++K ++H N++ Sbjct: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAK--STILKNRMVDQIKREISIMKIVRHPNIV 72 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 L +V S++Y+V + G + IV L ++ + QL+ + + H Sbjct: 73 RLYEVLASK------SKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCH 126 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLA---RQADEEMTGYVATRWYRAPEIMLNWMH 199 S G+ HRDLKP N+ ++ + L++ DFGL+ ++ E + T Y APE++ + Sbjct: 127 SKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGY 186 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPGSD 227 DIWS G I+ +L G F +D Sbjct: 187 DGSAADIWSCGVILFVILAGYLPFSETD 214 >4RLP-A nrPDB Length = 288 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 62/228 (27%), Positives = 112/228 (49%), Gaps = 17/228 (7%) Query: 21 PQRLQGLRPVGSGAYGSVC---SAYDARLRQKVAVKKLSRPF--QSLIHARRTYRELRLL 75 P+ + LR +G G YG V A + A+K L + ++ T E +L Sbjct: 4 PECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL 63 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTT-LMGADLNNIVKCQALSDEHVQ-FLVYQ 133 + +KH ++ L+ F ++YL+ L G +L ++ + + E F + + Sbjct: 64 EEVKHPFIVDLIYAFQTG------GKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAE 117 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT---GYVATRWYRA 190 + L ++H GII+RDLKP N+ +N +++ DFGL +++ + T + T Y A Sbjct: 118 ISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMA 177 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 238 PEI++ H N+ VD WS+G +M ++L G F G + + +I++ Sbjct: 178 PEILMRSGH-NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC 224 >5H2U-A nrPDB Length = 267 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 68/228 (29%), Positives = 116/228 (50%), Gaps = 24/228 (10%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 R +GSG +G V + R +VA+K +SR +L+H + E++ +K L+H++++ L Sbjct: 12 RKLGSGYFGEVFEGL-WKDRVQVAIKVISR--DNLLHQQMLQSEIQAMKKLRHKHILALY 68 Query: 88 DVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQ------FLVYQLLRGLKYI 141 V S+ D VY++T LM ++++ SDE V + +Q+ G+ Y+ Sbjct: 69 AV----VSVGD--PVYIITELMAK--GSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYL 120 Query: 142 HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM----TGYVATRWYRAPEIMLNW 197 S IHRDL N+ V E+ ++ DFGLAR E++ + +W APE L+ Sbjct: 121 ESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKW-TAPE-ALSR 178 Query: 198 MHYNQTVDIWSVGCIMAELL-QGKALFPGSDYIDQLKRIMEVVGTPSP 244 HY+ D+WS G ++ E+ +G+ +PG + R+ P P Sbjct: 179 GHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCP 226 >4KIK-B nrPDB Length = 677 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 61/213 (28%), Positives = 104/213 (48%), Gaps = 20/213 (9%) Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77 WE+ +RL G+G +G+V ++ +++A+K+ + S + R E+++++ Sbjct: 21 WEMKERL------GTGGFGNVIRWHNQETGEQIAIKQCRQEL-SPRNRERWCLEIQIMRR 73 Query: 78 LKHENVIGLLDVFTPATSI--EDFSEVYLVTTLMGADL----NNIVKCQALSDEHVQFLV 131 L H NV+ DV ++ D + + G DL N C L + + L+ Sbjct: 74 LTHPNVVAARDVPEGMQNLAPNDLP-LLAMEYCQGGDLRKYLNQFENCCGLREGAILTLL 132 Query: 132 YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCEL---RILDFGLARQADEE--MTGYVATR 186 + L+Y+H IIHRDLKP N+ + + + +I+D G A++ D+ T +V T Sbjct: 133 SDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTL 192 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQG 219 Y APE +L Y TVD WS G + E + G Sbjct: 193 QYLAPE-LLEQQKYTVTVDYWSFGTLAFECITG 224 >5YKS-A nrPDB Length = 377 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 60/216 (27%), Positives = 111/216 (51%), Gaps = 12/216 (5%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 + +G G + V A +KVAVK + + + ++E+R +K ++H N++ L Sbjct: 41 KTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLY 100 Query: 88 DVFTPATSIEDFSEVYLVTTLM-GADLNNIVKC--QALSDEHVQFLVYQLLRGLKYIHSA 144 +V I+ +++YL+ L G D+ + + + L+++ + Q++ + Y H Sbjct: 101 EV------IDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 154 Query: 145 GIIHRDLKPSNVAVNEDCEL-RILDFGLAR--QADEEMTGYVATRWYRAPEIMLNWMHYN 201 ++HRDLKP NV E L ++ DFG + Q +++T + Y APEI+L + Sbjct: 155 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 214 Query: 202 QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME 237 VDIWS+G I+ L+ G+ F ++ + L IM+ Sbjct: 215 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMD 250 >2WTK-C nrPDB Length = 305 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 84/329 (25%), Positives = 140/329 (42%), Gaps = 64/329 (19%) Query: 30 VGSGAYGSVCSAYDAR--LRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 +G G+YG V D+ R+ V + K + + +E++LL+ L+H+NVI L+ Sbjct: 13 LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLV 72 Query: 88 DVFTPATSIEDFSEVYLVTTLMGADLNNIVK---------CQALSDEHVQFLVYQLLRGL 138 DV E+ ++Y+V + ++ CQA H F QL+ GL Sbjct: 73 DVLYN----EEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQA----HGYFC--QLIDGL 122 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR-----QADEEMTGYVATRWYRAPEI 193 +Y+HS GI+H+D+KP N+ + L+I G+A AD+ + ++ PEI Sbjct: 123 EYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEI 182 Query: 194 MLNWMHYNQ-TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 ++ VDIWS G + + G F G D + ++ E +G S + Sbjct: 183 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEG----DNIYKLFENIGKGSYAIPGDCG- 237 Query: 253 EHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYH 312 PP+ DLL ML + +R S + H++F + H Sbjct: 238 ----------PPLS----------------DLLKGMLEYEPAKRFSIRQIRQHSWFRKKH 271 Query: 313 DPEDEPEAEPYDESVEAKERTLEEWKELT 341 P + P P S + K+R W+ +T Sbjct: 272 PPAEAP--VPIPPSPDTKDR----WRSMT 294 >2HW6-A nrPDB Length = 307 Score = 84.3 bits (207), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 81/303 (26%), Positives = 137/303 (45%), Gaps = 50/303 (16%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR-RTYRELRLLKHLK-HENVIGLL 87 +G GAY V A + ++ AVK + + H+R R +RE+ L + ++N++ L+ Sbjct: 21 LGEGAYAKVQGAVSLQNGKEYAVKIIEK---QAGHSRSRVFREVETLYQCQGNKNILELI 77 Query: 88 DVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAG 145 + F ED + YLV + G+ L +I K + ++ +V + L ++H+ G Sbjct: 78 EFF------EDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKG 131 Query: 146 IIHRDLKPSNVAVNEDCE-------LRILDFGLARQ----------ADEEMTGYVATRWY 188 I HRDLKP N+ CE ++I DF L E+T + Y Sbjct: 132 IAHRDLKPENIL----CESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEY 187 Query: 189 RAPEIMLNW----MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSP 244 APE++ + Y++ D+WS+G ++ +L G F G D G Sbjct: 188 MAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD--------CGWDRG 239 Query: 245 EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 EV ++ + + P KD + I + A DL+ ++LV D+ QR+SAA+ L Sbjct: 240 EVCRVCQNKLFESIQEGKYEFPDKDWAHI----SSEAKDLISKLLVRDAKQRLSAAQVLQ 295 Query: 305 HAY 307 H + Sbjct: 296 HPW 298 >4CFF-A nrPDB Length = 571 Score = 84.3 bits (207), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 88/325 (27%), Positives = 139/325 (42%), Gaps = 44/325 (13%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 +G G +G V KVAVK L+R +SL + RE++ LK +H ++I L Sbjct: 41 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 100 Query: 89 VFTPATSIEDFSEVYLVTTLMGADL-NNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 V + T DF V + + G +L + I K + + + L Q+L + Y H ++ Sbjct: 101 VISTPT---DFFMV--MEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 155 Query: 148 HRDLKPSNVAVNEDCELRILDFGLARQAD--EEMTGYVATRWYRAPEIMLNWMHYNQTVD 205 HRDLKP NV ++ +I DFGL+ E + + Y APE++ ++ VD Sbjct: 156 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVD 215 Query: 206 IWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPM 265 IWS G I+ LL G F K+I R + +P Sbjct: 216 IWSCGVILYALLCGTLPFDDEHVPTLFKKI--------------------RGGVFYIPEY 255 Query: 266 PQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDE 325 + +++ LL ML +D +R + + H +F Q PE YD Sbjct: 256 LNRSVAT-----------LLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDA 304 Query: 326 SV---EAKERTLEEWKELTYQEVLS 347 +V EA + E++ E T EV++ Sbjct: 305 NVIDDEAVKEVCEKF-ECTESEVMN 328 >3COM-A nrPDB Length = 314 Score = 84.0 bits (206), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 60/224 (26%), Positives = 116/224 (51%), Gaps = 20/224 (8%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 L +G G+YGSV A Q VA+K++ P +S + + +E+ +++ +V+ Sbjct: 34 LEKLGEGSYGSVYKAIHKETGQIVAIKQV--PVESDL--QEIIKEISIMQQCDSPHVVKY 89 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVKC--QALSDEHVQFLVYQLLRGLKYIHS 143 + T ++++V GA +++I++ + L+++ + ++ L+GL+Y+H Sbjct: 90 YGSYFKNT------DLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHF 143 Query: 144 AGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM---TGYVATRWYRAPEIMLNWMHY 200 IHRD+K N+ +N + ++ DFG+A Q + M + T ++ APE+ + + Y Sbjct: 144 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV-IQEIGY 202 Query: 201 NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSP 244 N DIWS+G E+ +GK P +D I ++ I + P P Sbjct: 203 NCVADIWSLGITAIEMAEGKP--PYAD-IHPMRAIFMIPTNPPP 243 >5EZV-A nrPDB Length = 560 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 89/325 (27%), Positives = 140/325 (43%), Gaps = 44/325 (13%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 +G G +G V KVAVK L+R +SL + RE++ LK +H ++I L Sbjct: 36 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 95 Query: 89 VFTPATSIEDFSEVYLVTTLMGADL-NNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 V + T DF V + + G +L + I K + + + L Q+L + Y H ++ Sbjct: 96 VISTPT---DFFMV--MEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 150 Query: 148 HRDLKPSNVAVNEDCELRILDFGLARQAD--EEMTGYVATRWYRAPEIMLNWMHYNQTVD 205 HRDLKP NV ++ +I DFGL+ E + + Y APE++ ++ VD Sbjct: 151 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVD 210 Query: 206 IWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPM 265 IWS G I+ LL G F P + KI R + +P Sbjct: 211 IWSCGVILYALLCGTLPFDDEHV---------------PTLFKKI-----RGGVFYIPEY 250 Query: 266 PQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDE 325 + +++ LL ML +D +R + + H +F Q PE YD Sbjct: 251 LNRSVAT-----------LLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDA 299 Query: 326 SV---EAKERTLEEWKELTYQEVLS 347 +V EA + E++ E T EV++ Sbjct: 300 NVIDDEAVKEVCEKF-ECTESEVMN 323 >5FET-A nrPDB Length = 847 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 64/219 (29%), Positives = 111/219 (50%), Gaps = 11/219 (5%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLS-RPFQSLIHARRTYRELRLLKHLKHEN 82 L+ R +G G +G+V + + + A+K +S R SL E + H Sbjct: 535 LETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHPF 594 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLM-GADL-NNIVKCQALSDEHVQFLVYQLLRGLKY 140 +I L+ F +D + Y +T L+ G +L + I K LS QF + ++ ++Y Sbjct: 595 IIRLVRTF------KDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEY 648 Query: 141 IHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHY 200 +H I++RDLKP N+ +++ ++++DFG A++ V T Y APE++L Y Sbjct: 649 LHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTLVGTPHYMAPEVILG-KGY 707 Query: 201 NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVV 239 TVDIW++G + E + G F G+D DQL+ +++ Sbjct: 708 GCTVDIWALGVCLYEFICGPLPF-GNDQEDQLEIFRDIL 745 >4EQM-A nrPDB Length = 294 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 63/238 (26%), Positives = 114/238 (47%), Gaps = 13/238 (5%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA-RRTYRELRLLKHL 78 + +R + + +G G +V A D L KVA+K + P + +R RE+ L Sbjct: 9 INERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQL 68 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-LSDEHVQFLVYQLLRG 137 H+N++ ++DV ED ++ + G L+ ++ LS + Q+L G Sbjct: 69 SHQNIVSMIDV-----DEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDG 123 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE----EMTGYVATRWYRAPEI 193 +K+ H I+HRD+KP N+ ++ + L+I DFG+A+ E + + T Y +PE Sbjct: 124 IKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPE- 182 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID-QLKRIMEVVGTPSPEVLAKI 250 ++ DI+S+G ++ E+L G+ F G + +K I + V + +V I Sbjct: 183 QAKGEATDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDI 240 >1VZO-A nrPDB Length = 355 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 78/301 (25%), Positives = 142/301 (47%), Gaps = 49/301 (16%) Query: 27 LRPVGSGAYGSV-----CSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 L+ +G+GAYG V S +D + V K + Q T E ++L+H++ Sbjct: 59 LKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQS 118 Query: 82 -NVIGLLDVFTPATSIEDFSEVYLVTTLMGADL-NNIVKCQALSDEHVQFLVYQLLRGLK 139 ++ L F T + ++ + G +L ++ + + ++ VQ V +++ L+ Sbjct: 119 PFLVTLHYAFQTETKLH-----LILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 173 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ--ADEEMTGY--VATRWYRAPEIML 195 ++H GII+RD+K N+ ++ + + + DFGL+++ ADE Y T Y AP+I+ Sbjct: 174 HLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPDIVR 233 Query: 196 NW-MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH 254 +++ VD WS+G +M ELL G + F V G + + +E Sbjct: 234 GGDSGHDKAVDWWSLGVLMYELLTGASPFT-------------VDGEKNSQ------AEI 274 Query: 255 ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS-----AAEALAHAYFS 309 +R ++S PP PQ+ + LA DL+ R+L+ D +R+ A E H +F Sbjct: 275 SRRILKSEPPYPQE--------MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQ 326 Query: 310 Q 310 + Sbjct: 327 K 327 >4TNB-A nrPDB Length = 590 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 70/251 (27%), Positives = 121/251 (48%), Gaps = 33/251 (13%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR----TYRELRLLKHLKHENV 83 R +G G +G VC+ + A K+L + I R+ E ++L+ + + V Sbjct: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEK---KRIKKRKGESMALNEKQILEKVNSQFV 246 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA---LSDEHVQFLVYQLLRGLK 139 + L A + E + LV T+M G DL + +E F ++L GL+ Sbjct: 247 VNL------AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVATRWYRAPEIMLNW 197 +H ++RDLKP N+ +++ +RI D GLA + E + G V T Y APE+ LN Sbjct: 301 DLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV-LNN 359 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPG------SDYIDQLKRIMEVVGTPSPEVLAKIS 251 Y + D W +GC++ E+++G++ F G + +D +R++E + EV + Sbjct: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVD--RRVLE-----TEEVYSHKF 412 Query: 252 SEHARTYIQSL 262 SE A++ + L Sbjct: 413 SEEAKSICKML 423 >2BDW-A nrPDB Length = 362 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 80/262 (30%), Positives = 123/262 (46%), Gaps = 48/262 (18%) Query: 50 VAVKKLS-RPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTL 108 + KKLS R FQ L RE R+ + L+H N++ L D SI++ S YLV L Sbjct: 62 INTKKLSARDFQKL------EREARICRKLQHPNIVRLHD------SIQEESFHYLVFDL 109 Query: 109 M--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE--- 163 + G +IV + S+ + Q+L + Y HS GI+HR+LKP N+ + + Sbjct: 110 VTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRNLKPENLLLASKAKGAA 169 Query: 164 LRILDFGLARQAD--EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKA 221 +++ DFGLA + + E G+ T Y +PE+ L Y++ VDIW+ G I+ LL G Sbjct: 170 VKLADFGLAIEVNDSEAWHGFAGTPGYLSPEV-LKKDPYSKPVDIWACGVILYILLVGYP 228 Query: 222 LFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLA 281 F D + A+I + A Y P P+ D P A Sbjct: 229 PFWDED---------------QHRLYAQIKA-GAYDY-----PSPEWDT------VTPEA 261 Query: 282 IDLLGRMLVLDSDQRVSAAEAL 303 L+ ML ++ +R++A +AL Sbjct: 262 KSLIDSMLTVNPKKRITADQAL 283 >4APC-A nrPDB Length = 350 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 104/217 (47%), Gaps = 14/217 (6%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 L+ +G G++G ++ +K+++ S + RE+ +L ++KH N++ Sbjct: 29 LQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQY 88 Query: 87 LDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA---LSDEHVQFLVYQLLRGLKYIH 142 + F E+ +Y+V G DL + Q ++ + Q+ LK++H Sbjct: 89 RESF------EENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 142 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD---EEMTGYVATRWYRAPEIMLNWMH 199 I+HRD+K N+ + +D +++ DFG+AR + E + T +Y +PEI N Sbjct: 143 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICEN-KP 201 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 YN DIW++GC++ EL K F + + +I+ Sbjct: 202 YNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKII 238 >3KK8-A nrPDB Length = 284 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 80/262 (30%), Positives = 123/262 (46%), Gaps = 48/262 (18%) Query: 50 VAVKKLS-RPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTL 108 + KKLS R FQ L RE R+ + L+H N++ L D SI++ S YLV L Sbjct: 39 INTKKLSARDFQKL------EREARICRKLQHPNIVRLHD------SIQEESFHYLVFDL 86 Query: 109 M--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE--- 163 + G +IV + S+ + Q+L + Y HS GI+HR+LKP N+ + + Sbjct: 87 VTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRNLKPENLLLASKAKGAA 146 Query: 164 LRILDFGLARQAD--EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKA 221 +++ DFGLA + + E G+ T Y +PE+ L Y++ VDIW+ G I+ LL G Sbjct: 147 VKLADFGLAIEVNDSEAWHGFAGTPGYLSPEV-LKKDPYSKPVDIWACGVILYILLVGYP 205 Query: 222 LFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLA 281 F D + A+I + A Y P P+ D P A Sbjct: 206 PFWDED---------------QHRLYAQIKAG-AYDY-----PSPEWDT------VTPEA 238 Query: 282 IDLLGRMLVLDSDQRVSAAEAL 303 L+ ML ++ +R++A +AL Sbjct: 239 KSLIDSMLTVNPKKRITADQAL 260 >3A4O-X nrPDB Length = 286 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 74/246 (30%), Positives = 118/246 (47%), Gaps = 29/246 (11%) Query: 14 NKTVWEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYREL 72 +K WE+P + ++ ++ +G+G +G V Y KVAVK L +P + A E Sbjct: 4 DKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN-STKVAVKTL-KPGTMSVQA--FLEEA 59 Query: 73 RLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDEHVQFLV 131 L+K L+H+ ++ L V T I Y++T M L + +K SDE + L+ Sbjct: 60 NLMKTLQHDKLVRLYAVVTREEPI------YIITEYMAKGSLLDFLK----SDEGGKVLL 109 Query: 132 -------YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYV 183 Q+ G+ YI IHRDL+ +NV V+E +I DFGLAR D E T Sbjct: 110 PKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTARE 169 Query: 184 ATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVV 239 ++ + APE +N+ + D+WS G ++ E++ GK +PG D + + + Sbjct: 170 GAKFPIKWTAPE-AINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGY 228 Query: 240 GTPSPE 245 P E Sbjct: 229 RMPRVE 234 >4U41-A nrPDB Length = 332 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 52/201 (25%), Positives = 94/201 (46%), Gaps = 13/201 (6%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 VG+G YG V + Q A+K + + L+ H H N+ Sbjct: 32 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSH--HRNIATYYGA 89 Query: 90 FTPATSIEDFSEVYLVTTLMGA----DLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAG 145 F + +++LV GA DL K L ++ + ++ ++LRGL ++H Sbjct: 90 FIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHH 149 Query: 146 IIHRDLKPSNVAVNEDCELRILDFGLARQADEEM---TGYVATRWYRAPEIMLNWMH--- 199 +IHRD+K NV + E+ E++++DFG++ Q D + ++ T ++ APE++ + Sbjct: 150 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 209 Query: 200 -YNQTVDIWSVGCIMAELLQG 219 Y+ D+WS G E+ +G Sbjct: 210 TYDYRSDLWSCGITAIEMAEG 230 >4AF3-A nrPDB Length = 292 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 103/218 (47%), Gaps = 17/218 (7%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA----RRTYRELRLLKHLKHENV 83 RP+G G +G+V A + + VA+K L F+S I + RE+ + HL H N+ Sbjct: 29 RPLGKGKFGNVYLAREKKSHFIVALKVL---FKSQIEKEGVEHQLRREIEIQAHLHHPNI 85 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYI 141 + L + F D +YL+ G + K ++ ++ +L L Y Sbjct: 86 LRLYNYFY------DRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYC 139 Query: 142 HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE-EMTGYVATRWYRAPEIMLNWMHY 200 H +IHRD+KP N+ + EL+I DFG + A T Y PE++ MH Sbjct: 140 HGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMH- 198 Query: 201 NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 238 N+ VD+W +G + ELL G F + + + +RI++V Sbjct: 199 NEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV 236 >3GQL-A nrPDB Length = 326 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 75/241 (31%), Positives = 116/241 (48%), Gaps = 41/241 (17%) Query: 18 WEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQ-------KVAVKKLS-----RPFQSLIH 64 WE+P+ RL +P+G GA+G V A L + KVAVK L + LI Sbjct: 23 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLI- 81 Query: 65 ARRTYRELRLLKHL-KHENVIGLLDVFT---PATSIEDF-SEVYLVTTLMGADLNNIVKC 119 E+ ++K + KH+N+I LL T P I ++ S+ L L + C Sbjct: 82 -----SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYC 136 Query: 120 --------QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGL 171 + LS + + YQ+ RG++Y+ S IHRDL NV V ED ++I DFGL Sbjct: 137 YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGL 196 Query: 172 ARQA------DEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFP 224 AR + G + +W APE + + ++ +Q+ D+WS G ++ E+ G + +P Sbjct: 197 ARDIHHIDYYKKTTNGRLPVKWM-APEALFDRIYTHQS-DVWSFGVLLWEIFTLGGSPYP 254 Query: 225 G 225 G Sbjct: 255 G 255 >2JD5-A nrPDB Length = 373 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 87/324 (26%), Positives = 146/324 (45%), Gaps = 48/324 (14%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKH------ 80 +R +G G + +V A D VA+K + ++ E++LL+ + Sbjct: 24 VRKLGWGHFSTVWLAKDMVNNTHVAMKIVR---GDKVYTEAAEDEIKLLQRVNDADNTKE 80 Query: 81 -----ENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK---CQALSDEHVQFLVY 132 +++ LLD F + V +V ++G +L ++K + + +V+ + Sbjct: 81 DSMGANHILKLLDHFNHKGP--NGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISK 138 Query: 133 QLLRGLKYIHS-AGIIHRDLKPSNVAVN------EDCELRILDFGLARQADEEMTGYVAT 185 QLL GL Y+H GIIH D+KP NV + +++I D G A DE T + T Sbjct: 139 QLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYTNSIQT 198 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALF---PGSDYI---DQLKRIMEVV 239 R YR+PE++L + DIWS C++ EL+ G LF G Y D + +I+E++ Sbjct: 199 REYRSPEVLLG-APWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIELL 257 Query: 240 GTPSPEVLAKISSEHARTYIQS---------LPPMPQKD-LSSIFRGANPLA---IDLLG 286 G P L + + ++ RT+ S L P +D L+ ++ + A D L Sbjct: 258 GE-LPSYLLR-NGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDFLS 315 Query: 287 RMLVLDSDQRVSAAEALAHAYFSQ 310 ML LD +R A + H + Sbjct: 316 PMLQLDPRKRADAGGLVNHPWLKD 339 >2DQ7-X nrPDB Length = 283 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 69/242 (28%), Positives = 120/242 (49%), Gaps = 24/242 (9%) Query: 15 KTVWEVP-QRLQGLRPVGSGAYGSV-CSAYDARLRQKVAVKKLSRPFQSLIHARRTYREL 72 K VWE+P + LQ ++ +G+G +G V ++ KVA+K L +P + E Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGN--TKVAIKTL-KP--GTMSPESFLEEA 55 Query: 73 RLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVK---CQALSDEHVQ 128 +++K LKH+ ++ L V + +Y+VT M L + +K +AL ++ Sbjct: 56 QIMKKLKHDKLVQLYAVVSE-------EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLV 108 Query: 129 FLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRW 187 + Q+ G+ YI IHRDL+ +N+ V +I DFGLAR D E T ++ Sbjct: 109 DMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKF 168 Query: 188 ---YRAPEIMLNWMHYNQTVDIWSVGCIMAELL-QGKALFPGSDYIDQLKRIMEVVGTPS 243 + APE L + + D+WS G ++ EL+ +G+ +PG + + L+++ P Sbjct: 169 PIKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPC 227 Query: 244 PE 245 P+ Sbjct: 228 PQ 229 >5A46-A nrPDB Length = 386 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 74/241 (30%), Positives = 115/241 (47%), Gaps = 41/241 (17%) Query: 18 WEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQ-------KVAVKKLS-----RPFQSLIH 64 WE+P+ RL +P+G G +G V A L + KVAVK L + LI Sbjct: 35 WELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLIS 94 Query: 65 ARRTYRELRLLKHL-KHENVIGLLDVFT---PATSIEDF-SEVYLVTTLMGADLNNIVKC 119 E+ ++K + KH+N+I LL T P I ++ S+ L L + C Sbjct: 95 ------EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYC 148 Query: 120 --------QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGL 171 + LS + + YQ+ RG++Y+ S IHRDL NV V ED ++I DFGL Sbjct: 149 YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGL 208 Query: 172 ARQA------DEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFP 224 AR + G + +W APE + + ++ +Q+ D+WS G ++ E+ G + +P Sbjct: 209 ARDIHHIDYYKKTTNGRLPVKWM-APEALFDRIYTHQS-DVWSFGVLLWEIFTLGGSPYP 266 Query: 225 G 225 G Sbjct: 267 G 267 >5EG3-A nrPDB Length = 334 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 69/242 (28%), Positives = 116/242 (47%), Gaps = 43/242 (17%) Query: 18 WEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR------ 70 WE P+ +L +P+G GA+G V A + V + K +P +++ A + + Sbjct: 30 WEFPRDKLTLGKPLGEGAFGQVVMA------EAVGIDK-DKPKEAVTVAVKMLKDDATEK 82 Query: 71 -------ELRLLKHL-KHENVIGLLD---------VFTPATSIEDFSEVYLVTTLMGADL 113 E+ ++K + KH+N+I LL V S + E G +L Sbjct: 83 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMEL 142 Query: 114 N---NIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFG 170 + N V + ++ + + YQL RG++Y+ S IHRDL NV V E+ ++I DFG Sbjct: 143 SPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 202 Query: 171 LARQAD------EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALF 223 LAR + E G + +W APE + + ++ +Q+ D+WS G +M E+ G + + Sbjct: 203 LARDINNIDFFKETTNGRLPVKWM-APEALFDRVYTHQS-DVWSFGVLMWEIFTLGGSPY 260 Query: 224 PG 225 PG Sbjct: 261 PG 262 >2BRG-A nrPDB Length = 297 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 61/208 (29%), Positives = 99/208 (47%), Gaps = 16/208 (7%) Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77 W++ Q L G GAYG V A + + VAVK + +++ +E+ + K Sbjct: 9 WDLVQTL------GEGAYGEVQLAVNRVTEEAVAVKIVDMK-RAVDCPENIKKEICINKM 61 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRG 137 L HENV+ F + ++L G + I + + Q +QL+ G Sbjct: 62 LNHENVVK----FYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAG 117 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLA---RQADEE--MTGYVATRWYRAPE 192 + Y+H GI HRD+KP N+ ++E L+I DFGLA R + E + T Y APE Sbjct: 118 VVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPE 177 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGK 220 ++ + + VD+WS G ++ +L G+ Sbjct: 178 LLKRREFHAEPVDVWSCGIVLTAMLAGE 205 >6CQF-A nrPDB Length = 297 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 54/197 (27%), Positives = 100/197 (50%), Gaps = 15/197 (7%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 L+ +G G YG V A D VA+K + + + +E+ +LK +H N++ Sbjct: 21 LQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ--KEILILKTCRHANIVAY 78 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVKCQ-ALSDEHVQFLVYQLLRGLKYIHSA 144 + ++++ GA L +I + +LS+ + ++ ++L+GL Y+HS Sbjct: 79 HGSYLW------LQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQ 132 Query: 145 GIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT---GYVATRWYRAPEIMLNWMH-- 199 IHRD+K +N+ +N+ E+R+ DFG++ Q + ++ T ++ APE+ + Sbjct: 133 KKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKGG 192 Query: 200 YNQTVDIWSVGCIMAEL 216 YN+ DIWS+G EL Sbjct: 193 YNELCDIWSLGITAIEL 209 >4LG4-A nrPDB Length = 299 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 69/290 (23%), Positives = 133/290 (45%), Gaps = 45/290 (15%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 L +G G+YGSV A Q VA+K++ P +S + + +E+ +++ V+ Sbjct: 16 LEKLGEGSYGSVFKAIHKESGQVVAIKQV--PVESDL--QEIIKEISIMQQCDSPYVVKY 71 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVKC--QALSDEHVQFLVYQLLRGLKYIHS 143 + T ++++V GA +++I++ + L ++ + ++ L+GL+Y+H Sbjct: 72 YGSYFKNT------DLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 125 Query: 144 AGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM---TGYVATRWYRAPEIMLNWMHY 200 IHR++K N+ +N + ++ DFG+A Q + M + T ++ APE+ + + Y Sbjct: 126 MRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV-IQEIGY 184 Query: 201 NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQ 260 N DIWS+G E+ +GK P +D I ++ I + P P Sbjct: 185 NCVADIWSLGITSIEMAEGKP--PYAD-IHPMRAIFMIPTNPPPTFRK------------ 229 Query: 261 SLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 P + D + D + + LV + +QR +A + L H + Sbjct: 230 --PELWSDDFT-----------DFVKKCLVKNPEQRATATQLLQHPFIKN 266 >4CQG-A nrPDB Length = 331 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 68/287 (23%), Positives = 125/287 (43%), Gaps = 44/287 (15%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G+G + V A + VA+K + + R E+ LK L+H+++ L V Sbjct: 17 IGTGGFAKVKLACHVLTGEMVAIKIMDKNALG-SDLPRVKTEIDALKSLRHQHICQLYHV 75 Query: 90 FTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 +E +++++V G + I+ LS+E + + Q+L + Y+HS G Sbjct: 76 ------LETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGYA 129 Query: 148 HRDLKPSNVAVNEDCELRILDFGLARQ----ADEEMTGYVATRWYRAPEIMLNWMHYNQT 203 HRDLKP N+ +E+ +L+++DFGL + D + + Y APE++ + Sbjct: 130 HRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYLGSE 189 Query: 204 VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLP 263 D+WS+G ++ L+ G F + + K+IM Sbjct: 190 ADVWSMGILLYVLMCGFLPFDDDNVMALYKKIM--------------------------- 222 Query: 264 PMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + + + +P +I LL +ML +D +R+S L H + Q Sbjct: 223 ----RGKYEVPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQ 265 >6AO5-A nrPDB Length = 362 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 69/290 (23%), Positives = 133/290 (45%), Gaps = 45/290 (15%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 L +G G+YGSV A Q VA+K++ P +S + + +E+ +++ V+ Sbjct: 15 LEKLGEGSYGSVFKAIHKESGQVVAIKQV--PVESDL--QEIIKEISIMQQCDSPYVVKY 70 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVKC--QALSDEHVQFLVYQLLRGLKYIHS 143 + T ++++V GA +++I++ + L ++ + ++ L+GL+Y+H Sbjct: 71 YGSYFKNT------DLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 124 Query: 144 AGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM---TGYVATRWYRAPEIMLNWMHY 200 IHR++K N+ +N + ++ DFG+A Q + M + T ++ APE+ + + Y Sbjct: 125 MRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV-IQEIGY 183 Query: 201 NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQ 260 N DIWS+G E+ +GK P +D I ++ I + P P Sbjct: 184 NCVADIWSLGITSIEMAEGKP--PYAD-IHPMRAIFMIPTNPPPTFRK------------ 228 Query: 261 SLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 P + D + D + + LV + +QR +A + L H + Sbjct: 229 --PELWSDDFT-----------DFVKKCLVKNPEQRATATQLLQHPFIKN 265 >3CJF-A nrPDB Length = 309 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 73/249 (29%), Positives = 121/249 (48%), Gaps = 28/249 (11%) Query: 10 RQELNKTVWEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQK------VAVKKLSRPFQSL 62 R + + WE P+ RL +P+G GA+G V A DA K VAVK L Sbjct: 14 RLPYDASKWEFPRDRLNLGKPLGRGAFGQVIEA-DAFGIDKTATCRTVAVKMLKEGATHS 72 Query: 63 IHARRTYRELRLLKHLKHE-NVIGLLDVFT----PATSIEDFSEVYLVTTLMGADLNNIV 117 H R EL++L H+ H NV+ LL T P I +F + ++T + + N V Sbjct: 73 EH-RALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFV 131 Query: 118 KCQAL-----SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLA 172 + L + EH+ +Q+ +G++++ S IHRDL N+ ++E ++I DFGLA Sbjct: 132 PYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLA 191 Query: 173 RQADEE------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPG 225 R ++ + +W APE + + ++ Q+ D+WS G ++ E+ G + +PG Sbjct: 192 RDIYKDPDYVRKGDARLPLKWM-APETIFDRVYTIQS-DVWSFGVLLWEIFSLGASPYPG 249 Query: 226 SDYIDQLKR 234 ++ R Sbjct: 250 VKIDEEFCR 258 >2YZA-A nrPDB Length = 276 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 63/198 (31%), Positives = 96/198 (48%), Gaps = 9/198 (4%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 +G G +G V KVAVK L+R +SL + RE++ LK +H ++I L Sbjct: 19 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 78 Query: 89 VFTPATSIEDFSEVYLVTTLMGADL-NNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 V + T DF V + + G +L + I K + + + L Q+L + Y H ++ Sbjct: 79 VISTPT---DFFMV--MEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 133 Query: 148 HRDLKPSNVAVNEDCELRILDFGLARQAD--EEMTGYVATRWYRAPEIMLNWMHYNQTVD 205 HRDLKP NV ++ +I DFGL+ E + + Y APE++ ++ VD Sbjct: 134 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYAGPEVD 193 Query: 206 IWSVGCIMAELLQGKALF 223 IWS G I+ LL G F Sbjct: 194 IWSCGVILYALLCGTLPF 211 >3HDN-A nrPDB Length = 373 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 105/211 (49%), Gaps = 24/211 (11%) Query: 21 PQRLQGLRPVGSGAYGSVCSA--------YDARLRQKVAVKKLSRPFQSLIHARRTYREL 72 P L+ +G G++G V A Y ++ QK A+ L + + I + R Sbjct: 37 PSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAI--LKKKEEKHIMSERNV--- 91 Query: 73 RLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADL-NNIVKCQALSDEHVQFLV 131 LLK++KH ++GL F A + +++ + G +L ++ + + + +F Sbjct: 92 -LLKNVKHPFLVGLHFSFQTADKL-----YFVLDYINGGELFYHLQRERCFLEPRARFYA 145 Query: 132 YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE---MTGYVATRWY 188 ++ L Y+HS I++RDLKP N+ ++ + + DFGL ++ E + + T Y Sbjct: 146 AEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEY 205 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQG 219 APE+ L+ Y++TVD W +G ++ E+L G Sbjct: 206 LAPEV-LHKQPYDRTVDWWCLGAVLYEMLYG 235 >3TT0-A nrPDB Length = 382 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 72/246 (29%), Positives = 114/246 (46%), Gaps = 51/246 (20%) Query: 18 WEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQ-------KVAVKKLS-----RPFQSLIH 64 WE+P+ RL +P+G GA+G V A L + KVAVK L + LI Sbjct: 64 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLI- 122 Query: 65 ARRTYRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC---- 119 E+ ++K + KH+N+I LL T +D +V +L ++ Sbjct: 123 -----SEMEMMKMIGKHKNIINLLGACT-----QDGPLYVIVEYASKGNLREYLQARRPP 172 Query: 120 -------------QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRI 166 + LS + + YQ+ RG++Y+ S IHRDL NV V ED ++I Sbjct: 173 GLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 232 Query: 167 LDFGLARQA------DEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-G 219 DFGLAR + G + +W APE + + ++ +Q+ D+WS G ++ E+ G Sbjct: 233 ADFGLARDIHHIDYYKKTTNGRLPVKWM-APEALFDRIYTHQS-DVWSFGVLLWEIFTLG 290 Query: 220 KALFPG 225 + +PG Sbjct: 291 GSPYPG 296 >2PSQ-A nrPDB Length = 370 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 70/242 (28%), Positives = 115/242 (47%), Gaps = 43/242 (17%) Query: 18 WEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQ-------KVAVKKLS-----RPFQSLIH 64 WE P+ +L +P+G G +G V A + + VAVK L + L+ Sbjct: 76 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS 135 Query: 65 ARRTYRELRLLKHL-KHENVIGLLDVFT---PATSIEDFSEVYLVTTLMGA--------- 111 E+ ++K + KH+N+I LL T P I +++ + + A Sbjct: 136 ------EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS 189 Query: 112 -DLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFG 170 D+N + + Q + V YQL RG++Y+ S IHRDL NV V E+ ++I DFG Sbjct: 190 YDINRVPEEQMTFKDLVS-CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 248 Query: 171 LARQAD------EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALF 223 LAR + + G + +W APE + + ++ +Q+ D+WS G +M E+ G + + Sbjct: 249 LARDINNIDYYKKTTNGRLPVKWM-APEALFDRVYTHQS-DVWSFGVLMWEIFTLGGSPY 306 Query: 224 PG 225 PG Sbjct: 307 PG 308 >5N23-A nrPDB Length = 352 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 73/282 (25%), Positives = 123/282 (43%), Gaps = 40/282 (14%) Query: 18 WEVP-------QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTY 69 WE P + + +R +G+G++G V A+K L + L T Sbjct: 31 WESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTL 90 Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHV 127 E R+ + + ++ L S +D S +Y+V G +++ + S+ H Sbjct: 91 NEKRIQQAVNFPFLVKL------EFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHA 144 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT-GYVATR 186 +F Q++ +Y+HS +I+RDLKP N+ +++ +++ DFG A++ T Sbjct: 145 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWTLCGTP 204 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEV 246 Y APEI+L+ YN+ VD W++G ++ E+ G F + DQ +I E Sbjct: 205 EYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPF----FADQPIQIYE--------- 250 Query: 247 LAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRM 288 KI S R P DL + R N L +DL R Sbjct: 251 --KIVSGKVR-----FPSHFSSDLKDLLR--NLLQVDLTKRF 283 >3DLS-A nrPDB Length = 335 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 53/210 (25%), Positives = 104/210 (49%), Gaps = 17/210 (8%) Query: 19 EVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH--------ARRTYR 70 E Q+ + P+GSGA+G V +A D ++V VK + + + ++ + Sbjct: 21 EYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKK--EKVLEDCWIEDPKLGKVTL 78 Query: 71 ELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV-QF 129 E+ +L ++H N+I +LD+F + F ++ + G DL + DE + + Sbjct: 79 EIAILSRVEHANIIKVLDIFEN----QGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASY 134 Query: 130 LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR--QADEEMTGYVATRW 187 + QL+ + Y+ IIHRD+K N+ + ED ++++DFG A + + + T Sbjct: 135 IFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIE 194 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 Y APE+++ + +++WS+G + L+ Sbjct: 195 YCAPEVLMGNPYRGPELEMWSLGVTLYTLV 224 >4B8L-A nrPDB Length = 286 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 97/218 (44%), Gaps = 17/218 (7%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA----RRTYRELRLLKHLKHENV 83 RP+G G +G+V Y AR +Q + L F+S + + RE+ + HL+H N+ Sbjct: 21 RPLGKGKFGNV---YLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNI 77 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYI 141 + + + F D +YL+ G + K ++ + +L L Y Sbjct: 78 LRMYNYF------HDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYC 131 Query: 142 HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE-EMTGYVATRWYRAPEIMLNWMHY 200 H +IHRD+KP N+ + EL+I DFG + A T Y PE++ H Sbjct: 132 HERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTH- 190 Query: 201 NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 238 ++ VD+W G + E L G F + + +RI+ V Sbjct: 191 DEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNV 228 >1KOB-A nrPDB Length = 387 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 71/279 (25%), Positives = 130/279 (46%), Gaps = 29/279 (10%) Query: 3 GPRAGFYRQELNKTVWE--VPQRL---QG--------LRPVGSGAYGSVCSAYDARLRQK 49 GP+ Y + + +W+ VPQ + QG L +GSGA+G V + + Sbjct: 20 GPKINDY-DKFYEDIWKKYVPQPVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKATGRV 78 Query: 50 VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM 109 K ++ P+ + E+ ++ L H +I L D F + + V ++ L Sbjct: 79 FVAKFINTPYP--LDKYTVKNEISIMNQLHHPKLINLHDAFE-----DKYEMVLILEFLS 131 Query: 110 GADLNNIVKCQ--ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVA--VNEDCELR 165 G +L + + + +S+ V + Q GLK++H I+H D+KP N+ + ++ Sbjct: 132 GGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVK 191 Query: 166 ILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALF 223 I+DFGLA + DE + AT + APEI ++ D+W++G + LL G + F Sbjct: 192 IIDFGLATKLNPDEIVKVTTATAEFAAPEI-VDREPVGFYTDMWAIGVLGYVLLSGLSPF 250 Query: 224 PGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSL 262 G D ++ L+ + + + +S E A+ +I++L Sbjct: 251 AGEDDLETLQNVKRCDWEFDEDAFSSVSPE-AKDFIKNL 288 >5DBX-A nrPDB Length = 328 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 62/210 (29%), Positives = 99/210 (47%), Gaps = 25/210 (11%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +GSGA V +A +++VA+K+++ + +E++ + H NV+ Sbjct: 19 IGSGATAVVQAALCKPRQERVAIKRINLE-KCQTSMDELLKEIQAMSQCSHPNVV----- 72 Query: 90 FTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEH---------VQFLVYQLLRGLK 139 T TS E++LV L+ G + +I+K EH + ++ ++L GL Sbjct: 73 -TYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLD 131 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFG----LARQAD----EEMTGYVATRWYRAP 191 Y+H G IHRDLK N+ + ED ++I DFG LA D + +V T + AP Sbjct: 132 YLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWMAP 191 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKA 221 E+M Y+ D+WS G EL G A Sbjct: 192 EVMEQVRGYDFKADMWSFGITAIELATGAA 221 >4D2V-A nrPDB Length = 356 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 71/301 (23%), Positives = 130/301 (43%), Gaps = 45/301 (14%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G+G + V A + VA+K + + R E+ LK+L+H+++ L V Sbjct: 37 IGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNLRHQHICQLYHV 95 Query: 90 FTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 A +++++V G + I+ LS+E + + Q++ + Y+HS G Sbjct: 96 LETA------NKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 149 Query: 148 HRDLKPSNVAVNEDCELRILDFGLARQ----ADEEMTGYVATRWYRAPEIMLNWMHYNQT 203 HRDLKP N+ +E +L+++DFGL + D + Y APE++ + Sbjct: 150 HRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYLGSE 209 Query: 204 VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLP 263 D+WS+G ++ L+ G P D + ++AKI Sbjct: 210 ADVWSMGILLYVLMCG--FLPFDD-------------DTAAALVAKI------------- 241 Query: 264 PMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ-YHDPEDEPEAEP 322 + + + +P +I LL +ML +D +R+S L H + Q Y+ P + P Sbjct: 242 ---MRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNP 298 Query: 323 Y 323 + Sbjct: 299 F 299 >1S9I-A nrPDB Length = 354 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 53/161 (32%), Positives = 82/161 (50%), Gaps = 9/161 (5%) Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK-CQALSDEHVQ 128 REL++L ++G F I E + G L+ ++K + + +E + Sbjct: 63 RELQVLHECNSPYIVGFYGAFYSDGEISICME-----HMDGGSLDQVLKEAKRIPEEILG 117 Query: 129 FLVYQLLRGLKYIHSA-GIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM-TGYVATR 186 + +LRGL Y+ I+HRD+KPSN+ VN E+++ DFG++ Q + M +V TR Sbjct: 118 KVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR 177 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD 227 Y APE L HY+ DIWS+G + EL G+ P D Sbjct: 178 SYMAPE-RLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPD 217 >3QA8-A nrPDB Length = 676 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 64/215 (29%), Positives = 101/215 (46%), Gaps = 24/215 (11%) Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77 WE+ +RL G+G +G V ++VA+K+ + S + R E++++K Sbjct: 16 WEMKERL------GTGGFGYVLRWIHQDTGEQVAIKQCRQEL-SPKNRERWCLEIQIMKK 68 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLM----GADL----NNIVKCQALSDEHVQF 129 L H NV+ +V ++ + L M G DL N C L + ++ Sbjct: 69 LNHPNVVSAREV---PDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRT 125 Query: 130 LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCEL---RILDFGLARQAD--EEMTGYVA 184 L+ + L+Y+H IIHRDLKP N+ + + +I+D G A++ D E T +V Sbjct: 126 LLSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVG 185 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQG 219 T Y APE +L Y TVD WS G + E + G Sbjct: 186 TLQYLAPE-LLEQKKYTVTVDYWSFGTLAFECITG 219 >3UC3-A nrPDB Length = 361 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 76/313 (24%), Positives = 125/313 (39%), Gaps = 46/313 (14%) Query: 5 RAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH 64 RA L+ + R ++ +GSG +G D ++ VAVK + R Sbjct: 3 RAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER---GAAI 59 Query: 65 ARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADL-NNIVKCQALS 123 RE+ + L+H N++ +V T + ++ G +L I S Sbjct: 60 DENVQREIINHRSLRHPNIVRFKEVILTPTHL-----AIIMEYASGGELYERICNAGRFS 114 Query: 124 DEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED--CELRILDFGLARQA--DEEM 179 ++ +F QLL G+ Y HS I HRDLK N ++ L+I DFG ++ + + Sbjct: 115 EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP 174 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG----SDYIDQLKRI 235 V T Y APE++L + + D+WS G + +L G F DY ++RI Sbjct: 175 KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI 234 Query: 236 MEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQ 295 + V + ++ +IS P L+ R+ V D Sbjct: 235 LSVKYSIPDDI--RIS---------------------------PECCHLISRIFVADPAT 265 Query: 296 RVSAAEALAHAYF 308 R+S E H++F Sbjct: 266 RISIPEIKTHSWF 278 >2PL0-A nrPDB Length = 289 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 63/218 (28%), Positives = 106/218 (48%), Gaps = 22/218 (10%) Query: 18 WEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLK 76 WEVP + L+ + +G+G +G V Y KVAVK L Q + E L+K Sbjct: 18 WEVPRETLKLVERLGAGQFGEVWMGY-YNGHTKVAVKSLK---QGSMSPDAFLAEANLMK 73 Query: 77 HLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA---LSDEHVQFLVY 132 L+H+ ++ L V T +Y++T M L + +K + L+ + + Sbjct: 74 QLQHQRLVRLYAVVTQ-------EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAA 126 Query: 133 QLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ-ADEEMTGYVATRW---Y 188 Q+ G+ +I IHRDL+ +N+ V++ +I DFGLAR D E T ++ + Sbjct: 127 QIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKW 186 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELL-QGKALFPG 225 APE +N+ + D+WS G ++ E++ G+ +PG Sbjct: 187 TAPE-AINYGTFTIKSDVWSFGILLTEIVTHGRIPYPG 223 >4M7I-A nrPDB Length = 299 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 61/249 (24%), Positives = 114/249 (45%), Gaps = 33/249 (13%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 ++ +G G +G V A + A+K++ P + L + RE++ L L+H ++ Sbjct: 10 IQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAR-EKVMREVKALAKLEHPGIVRY 68 Query: 87 LDVFTPATSIEDFS----EVYLVTTLMGADLNNIV-----KCQALSDEHVQFL--VYQLL 135 + + + E +VYL + N+ +C E L Q+ Sbjct: 69 FNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIA 128 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE---------------MT 180 ++++HS G++HRDLKPSN+ D +++ DFGL D++ T Sbjct: 129 EAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHT 188 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240 G V T+ Y +PE ++ Y+ VDI+S+G I+ EL L+P S +++++ + +V Sbjct: 189 GQVGTKLYMSPE-QIHGNSYSHKVDIFSLGLILFEL-----LYPFSTQMERVRTLTDVRN 242 Query: 241 TPSPEVLAK 249 P + + Sbjct: 243 LKFPPLFTQ 251 >2XIK-A nrPDB Length = 294 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 68/281 (24%), Positives = 130/281 (46%), Gaps = 22/281 (7%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G G++G V D ++ VA+K + ++ +E+ +L + Sbjct: 27 IGKGSFGEVYKGIDNHTKEVVAIKIIDLE-EAEDEIEDIQQEITVLSQCDSPYITRYFGS 85 Query: 90 FTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHR 149 + +T + E L G +++K L + ++ ++ ++L+GL Y+HS IHR Sbjct: 86 YLKSTKLWIIMEY-----LGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHR 140 Query: 150 DLKPSNVAVNEDCELRILDFGLARQADE---EMTGYVATRWYRAPEIMLNWMHYNQTVDI 206 D+K +NV ++E ++++ DFG+A Q + + +V T ++ APE+ + Y+ DI Sbjct: 141 DIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEV-IKQSAYDFKADI 199 Query: 207 WSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP 266 WS+G EL +G+ P SD R++ ++ SP L +H++ + + + Sbjct: 200 WSLGITAIELAKGEP--PNSDL--HPMRVLFLIPKNSPPTL---EGQHSKPFKEFVEACL 252 Query: 267 QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 KD FR P A +LL + ++ S L Y Sbjct: 253 NKDPR--FR---PTAKELLKHKFITRYTKKTSFLTELIDRY 288 >4QMW-A nrPDB Length = 310 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 51/197 (25%), Positives = 99/197 (50%), Gaps = 10/197 (5%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 L +G G++G V D R ++ VA+K + ++ +E+ +L V Sbjct: 34 LEKIGKGSFGEVFKGIDNRTQKVVAIKIIDL-EEAEDEIEDIQQEITVLSQCDSPYVTKY 92 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 + ++D ++ L G ++++ L + + ++ ++L+GL Y+HS Sbjct: 93 YGSY-----LKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKK 147 Query: 147 IHRDLKPSNVAVNEDCELRILDFGLARQADE---EMTGYVATRWYRAPEIMLNWMHYNQT 203 IHRD+K +NV ++E E+++ DFG+A Q + + +V T ++ APE+ + Y+ Sbjct: 148 IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEV-IKQSAYDSK 206 Query: 204 VDIWSVGCIMAELLQGK 220 DIWS+G EL +G+ Sbjct: 207 ADIWSLGITAIELARGE 223 >2JDO-A nrPDB Length = 342 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 83/353 (23%), Positives = 156/353 (44%), Gaps = 56/353 (15%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR----RTYRELRLLKHLKHEN 82 L+ +G G +G V + + A+K L + +I A+ T E R+L++ +H Sbjct: 15 LKLLGKGTFGKVILVREKATGRYYAMKILRK---EVIIAKDEVAHTVTESRVLQNTRHPF 71 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLN-NIVKCQALSDEHVQFLVYQLLRGLKYI 141 + L F + +++ G +L ++ + + ++E +F +++ L+Y+ Sbjct: 72 LTALKYAFQTHDRL-----CFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYL 126 Query: 142 HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE---MTGYVATRWYRAPEIMLNWM 198 HS +++RD+K N+ +++D ++I DFGL ++ + M + T Y APE++ + Sbjct: 127 HSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLED-N 185 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 Y + VD W +G +M E++ G+ F D+ +R+ E+ I E R Sbjct: 186 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----ERLFEL-----------ILMEEIR-- 228 Query: 259 IQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS-----AAEALAHAYF--SQY 311 P R +P A LL +L D QR+ A E + H +F + Sbjct: 229 ---FP-----------RTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINW 274 Query: 312 HDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSLEIEQ 364 D + P+ V ++ T E T Q + + PP+ G LE++Q Sbjct: 275 QDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSI-TITPPDRYDSLGLLELDQ 326 >6CKI-A nrPDB Length = 316 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 79/298 (26%), Positives = 129/298 (43%), Gaps = 40/298 (13%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR-RTYRELRLLKHLKHENVIGLLD 88 +G GA+ V + + Q+ AVK + + H R R +RE+ +L + G + Sbjct: 21 LGEGAHARVQTCINLITSQEYAVKIIEK---QPGHIRSRVFREVEMLYQCQ-----GHRN 72 Query: 89 VFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 V E+ YLV M G+ L++I K + ++ +V + L ++H+ GI Sbjct: 73 VLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGI 132 Query: 147 IHRDLKPSNVAV---NEDCELRILDFGLARQ----------ADEEMTGYVATRWYRAPEI 193 HRDLKP N+ N+ ++I DFGL + E+ + Y APE+ Sbjct: 133 AHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEV 192 Query: 194 MLNWMH----YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249 + + Y++ D+WS+G I+ LL G F G R G E Sbjct: 193 VEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVG--------RCGSDCGWDRGEACPA 244 Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 + + + P KD + I A DL+ ++LV D+ QR+SAA+ L H + Sbjct: 245 CQNMLFESIQEGKYEFPDKDWAHISCAAK----DLISKLLVRDAKQRLSAAQVLQHPW 298 >2W4O-A nrPDB Length = 349 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 81/274 (29%), Positives = 122/274 (44%), Gaps = 43/274 (15%) Query: 45 RLRQKVAVKKLS-RPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVY 103 R +QK K + + + + + E+ +L L H N+I L ++F T I E Sbjct: 71 RCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLE-- 128 Query: 104 LVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNE--- 160 LVT G + IV+ S+ V Q+L + Y+H GI+HRDLKP N+ Sbjct: 129 LVTG--GELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAP 186 Query: 161 DCELRILDFGLARQADEE--MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ 218 D L+I DFGL++ + + M T Y APEI L Y VD+WSVG I LL Sbjct: 187 DAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEI-LRGCAYGPEVDMWSVGIITYILLC 245 Query: 219 GKALF---PGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFR 275 G F G ++ +RI+ + Y S P D S+ Sbjct: 246 GFEPFYDERGDQFM--FRRIL-----------------NCEYYFIS----PWWDEVSLN- 281 Query: 276 GANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 A DL+ +++VLD +R++ +AL H + + Sbjct: 282 -----AKDLVRKLIVLDPKKRLTTFQALQHPWVT 310 >3DTC-A nrPDB Length = 271 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 69/241 (28%), Positives = 115/241 (47%), Gaps = 29/241 (12%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYR-ELRLLKHLKHENVIGLL 87 +G G +G V A+ + +VAVK P + + R E +L LKH N+I L Sbjct: 15 IGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 72 Query: 88 DVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI- 146 V +++ + ++ G LN ++ + + + + Q+ RG+ Y+H I Sbjct: 73 GV-----CLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIV 127 Query: 147 --IHRDLKPSNVAVNEDCE--------LRILDFGLARQ--ADEEMTGYVATRWYRAPEIM 194 IHRDLK SN+ + + E L+I DFGLAR+ +M+ A W APE++ Sbjct: 128 PIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYAWM-APEVI 186 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD-----YIDQLKRIMEVVGTPSPEVLAK 249 M +++ D+WS G ++ ELL G+ F G D Y + ++ + + PE AK Sbjct: 187 RASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAK 245 Query: 250 I 250 + Sbjct: 246 L 246 >4FZF-B nrPDB Length = 283 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 64/275 (23%), Positives = 129/275 (46%), Gaps = 22/275 (8%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 L +G G++G V D R +Q VA+K + ++ +E+ +L V Sbjct: 13 LERIGKGSFGEVFKGIDNRTQQVVAIKIIDLE-EAEDEIEDIQQEITVLSQCDSSYVTKY 71 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 + + + ++ L G ++++ + + ++ ++L+GL Y+HS Sbjct: 72 YGSYLKGSKL-----WIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKK 126 Query: 147 IHRDLKPSNVAVNEDCELRILDFGLARQADE---EMTGYVATRWYRAPEIMLNWMHYNQT 203 IHRD+K +NV ++E ++++ FG+A Q + + +V T ++ APE+ + Y+ Sbjct: 127 IHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEV-IQQSAYDSK 185 Query: 204 VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLP 263 DIWS+G EL +G+ P SD R++ ++ +P L + +++ + + Sbjct: 186 ADIWSLGITAIELAKGEP--PNSDM--HPMRVLFLIPKNNPPTLV---GDFTKSFKEFID 238 Query: 264 PMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS 298 KD S FR P A +LL ++ + ++ S Sbjct: 239 ACLNKDPS--FR---PTAKELLKHKFIVKNSKKTS 268 >4K33-A nrPDB Length = 325 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 66/235 (28%), Positives = 111/235 (47%), Gaps = 29/235 (12%) Query: 18 WEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT------YR 70 WE+ + RL +P+G GA+G V A + + A K ++ + L Sbjct: 31 WELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVS 90 Query: 71 ELRLLKHL-KHENVIGLLDVFT---PATSIEDFSEVYLVTTLMGA----DLNNIVKCQAL 122 E+ ++K + KH+N+I LL T P + +++ + + A L+ Sbjct: 91 EMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKP 150 Query: 123 SDEHVQF-----LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-- 175 +E + F YQ+ RG++Y+ S IHRDL NV V ED ++I DFGLAR Sbjct: 151 PEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHN 210 Query: 176 ----DEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPG 225 E G + +W APE + + ++ +Q+ D+WS G ++ E+ G + +PG Sbjct: 211 LDYYKETTNGRLPVKWM-APEALFDRVYTHQS-DVWSFGVLLWEIFTLGGSPYPG 263 >6ED6-A nrPDB Length = 415 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 67/248 (27%), Positives = 115/248 (46%), Gaps = 22/248 (8%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTY--RELRLLKHLKHENVI 84 ++ +G GA+G V + QKV KL F+ + + + E ++ V+ Sbjct: 93 VKVIGRGAFGEV-QLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVV 151 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHS 143 L F +D +Y+V M G DL N++ + ++ +F +++ L IHS Sbjct: 152 QLFYAF------QDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHS 205 Query: 144 AGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY------VATRWYRAPEIMLNW 197 G+IHRD+KP N+ +++ L++ DFG + DE TG V T Y +PE++ + Sbjct: 206 MGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDE--TGMVHCDTAVGTPDYISPEVLKSQ 263 Query: 198 ---MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH 254 Y + D WSVG + E+L G F + +IM+ + A+I S+H Sbjct: 264 GGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEI-SKH 322 Query: 255 ARTYIQSL 262 A+ I + Sbjct: 323 AKNLICAF 330 >5J5T-A nrPDB Length = 370 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 81/343 (23%), Positives = 155/343 (45%), Gaps = 38/343 (11%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLS-RPFQSLIHARRTYRELRLLKHLKHENVIG 85 ++ +GSG YG V A + + A+K + P + ++ E+ ++K KH N++ Sbjct: 9 IQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQ---EIIMMKDCKHPNIVA 65 Query: 86 LLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-LSDEHVQFLVYQLLRGLKYIHSA 144 + + E G L +I LS+ + ++ + L+GL Y+HS Sbjct: 66 YFGSYLRRDKLWICMEF-----CGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK 120 Query: 145 GIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT---GYVATRWYRAPEI--MLNWMH 199 G +HRD+K +N+ + ++ +++ DFG++ Q + ++ T ++ APE+ + Sbjct: 121 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGG 180 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGT----PSPEVLAKISSEHA 255 YNQ D+W+VG EL + L P + ++ + + + P + K S+ Sbjct: 181 YNQLCDLWAVGITAIELAE---LQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFH 237 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHD-P 314 +L P+K ++ +P L R L ++ +V+ + S YHD Sbjct: 238 HFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPD------HSTYHDFD 291 Query: 315 EDEPE---AEPYDESVEAKERTLEEWK---ELTYQEVLSFKPP 351 +D+PE A P+ + + R + E K E+T+ +V F PP Sbjct: 292 DDDPEPLVAVPH--RIHSTSRNVREEKTRSEITFGQV-KFDPP 331 >5LOH-A nrPDB Length = 341 Score = 77.8 bits (190), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 70/252 (27%), Positives = 120/252 (47%), Gaps = 31/252 (12%) Query: 27 LRPVGSGAYGSV-CSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIG 85 ++P+ GA+G V +L VKK +++ H + R+ L K ++ Sbjct: 41 VKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALS--KSPFIVH 98 Query: 86 LLDVFTPATSIEDFSEVYLVTT-LMGADLNNIVKCQALSDEHVQF-LVYQLLRGLKYIHS 143 L S++ + VYLV L+G D+ +++ DE + + ++ L Y+H Sbjct: 99 LY------YSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHR 152 Query: 144 AGIIHRDLKPSNVAVNEDCELRILDFGLAR---QADEEMTGYVATRW------YRAPEIM 194 GIIHRDLKP N+ ++ + +++ DFGL++ D M + TR Y APE++ Sbjct: 153 HGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELL 212 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKALF----PGSDYIDQLKRIMEVVGTPSPEVLAKI 250 L H VD W++G + E L G F P + + LKR + P PE K+ Sbjct: 213 LGRAH-GPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDI-----PWPEGEEKL 266 Query: 251 SSEHARTYIQSL 262 S++A++ ++ L Sbjct: 267 -SDNAQSAVEIL 277 >4UY9-A nrPDB Length = 323 Score = 77.8 bits (190), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 68/240 (28%), Positives = 113/240 (47%), Gaps = 27/240 (11%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYR-ELRLLKHLKHENVIGLL 87 +G G +G V A+ + +VAVK P + + R E +L LKH N+I L Sbjct: 17 IGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 74 Query: 88 DVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI- 146 V +++ + ++ G LN ++ + + + + Q+ RG+ Y+H I Sbjct: 75 GV-----CLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIV 129 Query: 147 --IHRDLKPSNVAVNEDCE--------LRILDFGLARQADEEMTGYVA-TRWYRAPEIML 195 IHRDLK SN+ + + E L+I DFGLAR+ A T + APE++ Sbjct: 130 PIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIR 189 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSD-----YIDQLKRIMEVVGTPSPEVLAKI 250 M +++ D+WS G ++ ELL G+ F G D Y + ++ + + PE AK+ Sbjct: 190 ASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKL 248 >2HK5-A nrPDB Length = 270 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 66/241 (27%), Positives = 116/241 (48%), Gaps = 22/241 (9%) Query: 15 KTVWEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELR 73 K WE+P + L+ + +G+G +G V A + KVAVK + +P + A E Sbjct: 7 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTM-KPGSMSVEA--FLAEAN 62 Query: 74 LLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDEHVQFLV- 131 ++K L+H+ ++ L V T +Y++T M L + +K S + + L+ Sbjct: 63 VMKTLQHDKLVKLHAVVTK-------EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID 115 Query: 132 --YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRW- 187 Q+ G+ +I IHRDL+ +N+ V+ +I DFGLAR D E T ++ Sbjct: 116 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP 175 Query: 188 --YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSP 244 + APE +N+ + D+WS G ++ E++ G+ +PG + ++ + P P Sbjct: 176 IKWTAPE-AINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP 234 Query: 245 E 245 E Sbjct: 235 E 235 >6BDL-A nrPDB Length = 347 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 64/233 (27%), Positives = 109/233 (46%), Gaps = 11/233 (4%) Query: 56 SRPFQSLIHARRTYRELRLLKHLKHENVI--GLLDVFTPAT--SIEDFSEVY-LVTTLMG 110 S+ F I +R + R +H++ E I G F + +D +Y L+ +G Sbjct: 60 SKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLG 119 Query: 111 ADLNNIVKCQ-ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDF 169 +L I++ + + D +F ++ Y+HS GII+RDLKP N+ ++ +++DF Sbjct: 120 GELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDF 179 Query: 170 GLARQA--DEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD 227 G A++ ++ + T Y APEI+LN H + + D WS+G +M ELL G F G D Sbjct: 180 GFAKKIGFGKKTWTFCGTPEYVAPEIILNKGH-DISADYWSLGILMYELLTGSPPFSGPD 238 Query: 228 YIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPL 280 + I+ G E KI+ A + P + L ++ G + Sbjct: 239 PMKTYNIILR--GIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDI 289 >3A8W-A nrPDB Length = 345 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 53/211 (25%), Positives = 104/211 (49%), Gaps = 18/211 (8%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL--- 78 Q LR +G G+Y V RL++ + + + L++ ++ KH+ Sbjct: 9 QDFDLLRVIGRGSYAKVLLV---RLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ 65 Query: 79 --KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLN-NIVKCQALSDEHVQFLVYQLL 135 H ++GL F + + +++ + G DL ++ + + L +EH +F ++ Sbjct: 66 ASNHPFLVGLHSCFQTESRL-----FFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEIS 120 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYRAPE 192 L Y+H GII+RDLK NV ++ + +++ D+G+ ++ + + + T Y APE Sbjct: 121 LALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPE 180 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALF 223 I L Y +VD W++G +M E++ G++ F Sbjct: 181 I-LRGEDYGFSVDWWALGVLMFEMMAGRSPF 210 >5UUU-A nrPDB Length = 547 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 49/198 (24%), Positives = 100/198 (50%), Gaps = 3/198 (1%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 R +G G +G V A + A+K L + + R++ L + Sbjct: 204 RIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFI 263 Query: 88 DVFTPATSIEDFSEVYLVTTLMGADLN-NIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 + A D +++ + G DL+ ++ + S+ ++F +++ GL+++H+ + Sbjct: 264 VCMSYAFHTPD-KLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFV 322 Query: 147 IHRDLKPSNVAVNEDCELRILDFGLARQ-ADEEMTGYVATRWYRAPEIMLNWMHYNQTVD 205 ++RDLKP+N+ ++E +RI D GLA + ++ V T Y APE++ + Y+ + D Sbjct: 323 VYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSAD 382 Query: 206 IWSVGCIMAELLQGKALF 223 +S+GC++ +LL+G + F Sbjct: 383 WFSLGCMLFKLLRGHSPF 400 >2H8H-A nrPDB Length = 535 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 67/240 (27%), Positives = 117/240 (48%), Gaps = 31/240 (12%) Query: 11 QELNKTVWEVPQRLQGLR---PVGSGAYGSV-CSAYDARLRQKVAVKKLSRPFQSLIHAR 66 Q L K WE+P+ + LR +G G +G V ++ R VA+K L +P + Sbjct: 255 QGLAKDAWEIPR--ESLRLEVKLGQGCFGEVWMGTWNGTTR--VAIKTL-KP--GTMSPE 307 Query: 67 RTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQA---L 122 +E +++K L+HE ++ L V + +Y+VT M L + +K + L Sbjct: 308 AFLQEAQVMKKLRHEKLVQLYAVVSE-------EPIYIVTEYMSKGSLLDFLKGETGKYL 360 Query: 123 SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ-ADEEMTG 181 + + Q+ G+ Y+ +HRDL+ +N+ V E+ ++ DFGLAR D E T Sbjct: 361 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 420 Query: 182 YVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAEL-LQGKALFPG---SDYIDQLKR 234 ++ + APE L + + D+WS G ++ EL +G+ +PG + +DQ++R Sbjct: 421 RQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 479 >5SYS-A nrPDB Length = 286 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 67/260 (25%), Positives = 122/260 (46%), Gaps = 26/260 (10%) Query: 11 QELNKTVWEVPQRLQGLR---PVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67 Q L K WE+P+ + LR +G G +G C +VA+K L +P + Sbjct: 6 QGLAKDAWEIPR--ESLRLEVKLGQGCFGE-CWMGTWNGTTRVAIKTL-KP--GTMSPEA 59 Query: 68 TYRELRLLKHLKHENVIGLLDVFT--PATSIEDFSEVYLVTTLMGADLNNIVKCQALSDE 125 +E +++K L+HE ++ L V + P + ++ + + ++ ++ L D Sbjct: 60 FLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVD- 118 Query: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ-ADEEMTGYVA 184 + Q+ G+ Y+ +HRDL+ +N+ V E+ ++ DFGLAR D E T Sbjct: 119 ----MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 174 Query: 185 TRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAEL-LQGKALFPG---SDYIDQLKRIME 237 ++ + APE L + + D+WS G ++ EL +G+ +PG + +DQ++R Sbjct: 175 AKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 233 Query: 238 VVGTP-SPEVLAKISSEHAR 256 + P PE L + + R Sbjct: 234 MPCPPECPESLHDLMCQCWR 253 >6GQK-A nrPDB Length = 328 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 74/256 (28%), Positives = 112/256 (43%), Gaps = 32/256 (12%) Query: 18 WEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQK-----VAVKKLSRPFQSLIHARRTYRE 71 WE P+ RL + +G+GA+G V A L + VAVK L +P E Sbjct: 36 WEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKML-KPSAHSTEREALMSE 94 Query: 72 LRLLKHL-KHENVIGLLDVFT---PATSIEDFSEVYLVTTLMGADLNNIVKCQA------ 121 L++L +L HEN++ LL T P I ++ + + + V + Sbjct: 95 LKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLY 154 Query: 122 ---LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE 178 L+ EH+ YQ+ +G+ ++ S IHRDL N+ + +I DFGLAR + Sbjct: 155 KDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKND 214 Query: 179 MTGYV-------ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYID 230 + YV +W APE + N + Y D+WS G + EL G + +PG Sbjct: 215 -SNYVDKGNARLPVKW-MAPESIFNSV-YTFESDVWSYGIFLWELFSLGSSPYPGMPVDS 271 Query: 231 QL-KRIMEVVGTPSPE 245 + K I E SPE Sbjct: 272 KFYKMIKEGFRMSSPE 287 >3PVW-A nrPDB Length = 695 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 49/198 (24%), Positives = 100/198 (50%), Gaps = 3/198 (1%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 R +G G +G V A + A+K L + + R++ L + Sbjct: 195 RIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFI 254 Query: 88 DVFTPATSIEDFSEVYLVTTLMGADLN-NIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 + A D +++ + G DL+ ++ + S+ ++F +++ GL+++H+ + Sbjct: 255 VCMSYAFHTPD-KLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFV 313 Query: 147 IHRDLKPSNVAVNEDCELRILDFGLARQ-ADEEMTGYVATRWYRAPEIMLNWMHYNQTVD 205 ++RDLKP+N+ ++E +RI D GLA + ++ V T Y APE++ + Y+ + D Sbjct: 314 VYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSAD 373 Query: 206 IWSVGCIMAELLQGKALF 223 +S+GC++ +LL+G + F Sbjct: 374 WFSLGCMLFKLLRGHSPF 391 >3LM0-A nrPDB Length = 327 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 59/223 (26%), Positives = 101/223 (45%), Gaps = 39/223 (17%) Query: 120 QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED---CELRILDFGLARQAD 176 + +S+ V L+ Q+L G+ Y+H I+H DLKP N+ ++ +++I+DFG++R+ Sbjct: 126 EMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIG 185 Query: 177 E--EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKR 234 E+ + T Y APEI LN+ D+W++G I LL + F G D + Sbjct: 186 HACELREIMGTPEYLAPEI-LNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLN 244 Query: 235 IMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSD 294 I +V S E + +S LA D + +LV + + Sbjct: 245 ISQVNVDYSEETFSSVSQ---------------------------LATDFIQSLLVKNPE 277 Query: 295 QRVSAAEALAHAYFSQ------YHDPEDEPEAEPYDESVEAKE 331 +R +A L+H++ Q +H E ++ D SV + E Sbjct: 278 KRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRSSE 320 >4XCU-A nrPDB Length = 300 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 71/233 (30%), Positives = 114/233 (48%), Gaps = 32/233 (13%) Query: 17 VWEVPQ-RLQGLRPVGSGAYGSVCSAY-----DARLRQ--KVAVKKLSRPFQSLIHARRT 68 +WE P+ RL +P+G G +G V A AR Q VAVK L + S Sbjct: 11 LWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKML-KDNASDKDLADL 69 Query: 69 YRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ---ALSD 124 E+ ++K + +H+N+I LL V T ++ +V +L ++ + S+ Sbjct: 70 VSEMEVMKLIGRHKNIINLLGVCT-----QEGPLYVIVECAAKGNLREFLRARRPPGSSE 124 Query: 125 EHVQFLV-----YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA---- 175 + F V YQ+ RG++Y+ S IHRDL NV V ED ++I DFGLAR Sbjct: 125 GPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHID 184 Query: 176 --DEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPG 225 + G + +W APE + + ++ +Q+ D+WS G ++ E+ G + +PG Sbjct: 185 YYKKTSNGRLPVKWM-APEALFDRVYTHQS-DVWSFGILLWEIFTLGGSPYPG 235 >4AN9-A nrPDB Length = 301 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 54/169 (31%), Positives = 84/169 (49%), Gaps = 15/169 (8%) Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQF 129 REL++L ++G F I E + G L+ ++K E + Sbjct: 56 RELQVLHECNSPYIVGFYGAFYSDGEISICME-----HMDGGSLDQVLKKAGRIPEQILG 110 Query: 130 LV-YQLLRGLKYIHSA-GIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTG-YVATR 186 V +++GL Y+ I+HRD+KPSN+ VN E+++ DFG++ Q +EM +V TR Sbjct: 111 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTR 170 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGK------ALFPGSDYI 229 Y +PE L HY+ DIWS+G + E+ G+ A+F DYI Sbjct: 171 SYMSPE-RLQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYI 218 >6E9W-A nrPDB Length = 443 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 58/221 (26%), Positives = 104/221 (47%), Gaps = 17/221 (7%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTY--RELRLLKHLKHENVI 84 ++ +G GA+G V R+ A+K LS+ F+ + + + E ++ V+ Sbjct: 107 VKVIGRGAFGEVQLVRHKSTRKVYAMKLLSK-FEMIKRSDSAFFWEERDIMAFANSPWVV 165 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHS 143 L F +D +Y+V M G DL N++ + ++ +F +++ L IHS Sbjct: 166 QLFYAF------QDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHS 219 Query: 144 AGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE----MTGYVATRWYRAPEIMLNW-- 197 G IHRD+KP N+ +++ L++ DFG + ++E V T Y +PE++ + Sbjct: 220 MGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGG 279 Query: 198 -MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME 237 +Y + D WSVG + E+L G F + +IM Sbjct: 280 DGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMN 320 >4UYA-A nrPDB Length = 340 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 75/253 (29%), Positives = 120/253 (47%), Gaps = 31/253 (12%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLR-QKVAVKKLSR-PFQ-SLIHARRTYRELRLLKHL 78 +RL+ +G+G +G V Y A + Q+VAVK + P Q + A RE RL L Sbjct: 26 ERLELKELIGAGGFGQV---YRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAML 82 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGL 138 +H N+I L V ++ ++ G LN + + + + Q+ RG+ Sbjct: 83 RHPNIIELRGV-----CLQQPHLCLVLEFARGGALNRALAGRRIPPHVLVNWAVQIARGM 137 Query: 139 KYIHSAG---IIHRDLKPSNVAVNEDCE--------LRILDFGLARQ--ADEEMTGYVAT 185 Y+H I+HRDLK SN+ + E E L+I DFGLAR+ +M A Sbjct: 138 LYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAY 197 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD-----YIDQLKRIMEVVG 240 W APE++ + + +++ DIWS G ++ ELL G+ + G D Y + ++ + Sbjct: 198 AWM-APEVIKSSL-FSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIP 255 Query: 241 TPSPEVLAKISSE 253 + PE AK+ E Sbjct: 256 STCPEPFAKLMKE 268 >6F3F-A nrPDB Length = 455 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 68/240 (28%), Positives = 117/240 (48%), Gaps = 31/240 (12%) Query: 11 QELNKTVWEVPQRLQGLR---PVGSGAYGSV-CSAYDARLRQKVAVKKLSRPFQSLIHAR 66 Q L K WE+P+ + LR +G G +G V ++ R VA+K L +P + Sbjct: 175 QGLAKDAWEIPR--ESLRLEVKLGQGCFGEVWMGTWNGTTR--VAIKTL-KP--GTMSPE 227 Query: 67 RTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDE 125 +E +++K L+HE ++ L V + +Y+VT M L + +K + Sbjct: 228 AFLQEAQVMKKLRHEKLVQLYAVVSE-------EPIYIVTEYMNKGSLLDFLKGETGKYL 280 Query: 126 HVQFLV---YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ-ADEEMTG 181 + LV Q+ G+ Y+ +HRDL+ +N+ V E+ ++ DFGLAR D E T Sbjct: 281 RLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 340 Query: 182 YVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAEL-LQGKALFPG---SDYIDQLKR 234 ++ + APE L + + D+WS G ++ EL +G+ +PG + +DQ++R Sbjct: 341 RQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 399 >5WAX-A nrPDB Length = 310 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 69/291 (23%), Positives = 117/291 (40%), Gaps = 38/291 (13%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 R + +R +GSG +G + Q VAVK + R + RE+ + L+H N Sbjct: 12 RYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKI---DENVQREIINHRSLRHPN 68 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 +I +V T + + + G I S++ +F QL+ G+ Y H Sbjct: 69 IIRFKEVILTPTHLA----IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH 124 Query: 143 SAGIIHRDLKPSNVAVNEDC--ELRILDFGLARQA--DEEMTGYVATRWYRAPEIMLNWM 198 S + HRDLK N ++ L+I DFG ++ + + V T Y APE++L Sbjct: 125 SMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 184 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKR-IMEVVGTPSPEVLAKISSEHART 257 + + D+WS G + +L G F D ++ I ++G Sbjct: 185 YDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQ--------------- 229 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 S+P + +P DL+ R+ V + R++ E H +F Sbjct: 230 --YSIPD---------YVHISPECQDLISRIFVANPATRITIPEIRNHPWF 269 >5KKR-C nrPDB Length = 395 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 49/161 (30%), Positives = 79/161 (49%), Gaps = 9/161 (5%) Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQF 129 REL++L ++G F I + + G L+ ++K E + Sbjct: 115 RELQVLHECNSPYIVGFYGAFYSDGEIS-----ICMEHMDGGSLDQVLKKAGRIPEQILG 169 Query: 130 LV-YQLLRGLKYIHSA-GIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM-TGYVATR 186 V +++GL Y+ I+HRD+KPSN+ VN E+++ DFG++ Q + M +V TR Sbjct: 170 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR 229 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD 227 Y +PE L HY+ DIWS+G + E+ G+ P D Sbjct: 230 SYMSPE-RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPD 269 >2WQN-A nrPDB Length = 310 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 69/252 (27%), Positives = 117/252 (46%), Gaps = 43/252 (17%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR---TYRELRLLKHLKHENVI 84 + +G G + V A VA+KK+ L+ A+ +E+ LLK L H NVI Sbjct: 38 KKIGRGQFSEVYRAACLLDGVPVALKKVQ--IFDLMDAKARADCIKEIDLLKQLNHPNVI 95 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVKC-----QALSDEHVQFLVYQLLRGL 138 A+ IED +E+ +V L A DL+ ++K + + + V QL L Sbjct: 96 KYY-----ASFIED-NELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSAL 149 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTG---YVATRWYRAPEIML 195 +++HS ++HRD+KP+NV + +++ D GL R + T V T +Y +PE + Sbjct: 150 EHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPE-RI 208 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALF----------------------PGSDYIDQLK 233 + YN DIWS+GC++ E+ ++ F P Y ++L+ Sbjct: 209 HENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELR 268 Query: 234 RIMEVVGTPSPE 245 +++ + P PE Sbjct: 269 QLVNMCINPDPE 280 >1AD5-A nrPDB Length = 438 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 64/237 (27%), Positives = 113/237 (47%), Gaps = 24/237 (10%) Query: 15 KTVWEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELR 73 K WE+P + L+ + +G+G +G V A + KVAVK + +P + A E Sbjct: 174 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTM-KPGSMSVEA--FLAEAN 229 Query: 74 LLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDEHVQFLV- 131 ++K L+H+ ++ L V T +Y++T M L + +K S + + L+ Sbjct: 230 VMKTLQHDKLVKLHAVVTK-------EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID 282 Query: 132 --YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYR 189 Q+ G+ +I IHRDL+ +N+ V+ +I DFGLAR + +W Sbjct: 283 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLAR-----VGAKFPIKW-T 336 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPE 245 APE +N+ + D+WS G ++ E++ G+ +PG + ++ + P PE Sbjct: 337 APE-AINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE 392 >3UTO-A nrPDB Length = 573 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 70/293 (23%), Positives = 124/293 (42%), Gaps = 45/293 (15%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G+GA+G V + A K + P +S R +E++ + L+H ++ L D Sbjct: 165 LGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVR--KEIQTMSVLRHPTLVNLHDA 222 Query: 90 FTPATSIEDFSEVYLVTTLM-GADLNNIV---KCQALSDEHVQFLVYQLLRGLKYIHSAG 145 F ED +E+ ++ M G +L V + DE V+++ Q+ +GL ++H Sbjct: 223 F------EDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYM-RQVCKGLCHMHENN 275 Query: 146 IIHRDLKPSNV--AVNEDCELRILDFGLARQADEEMTGYV--ATRWYRAPEIMLNWMHYN 201 +H DLKP N+ EL+++DFGL D + + V T + APE+ Sbjct: 276 YVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEG-KPVG 334 Query: 202 QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQS 261 D+WSVG + LL G + F G + + L+ + Sbjct: 335 YYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMD------------------ 376 Query: 262 LPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 314 S F G + D + ++L+ D + R++ +AL H + + + P Sbjct: 377 ---------DSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAP 420 >1KOA-A nrPDB Length = 491 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 70/293 (23%), Positives = 124/293 (42%), Gaps = 45/293 (15%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G+GA+G V + A K + P +S R +E++ + L+H ++ L D Sbjct: 59 LGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVR--KEIQTMSVLRHPTLVNLHDA 116 Query: 90 FTPATSIEDFSEVYLVTTLM-GADLNNIV---KCQALSDEHVQFLVYQLLRGLKYIHSAG 145 F ED +E+ ++ M G +L V + DE V+++ Q+ +GL ++H Sbjct: 117 F------EDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYM-RQVCKGLCHMHENN 169 Query: 146 IIHRDLKPSNV--AVNEDCELRILDFGLARQADEEMTGYV--ATRWYRAPEIMLNWMHYN 201 +H DLKP N+ EL+++DFGL D + + V T + APE+ Sbjct: 170 YVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEG-KPVG 228 Query: 202 QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQS 261 D+WSVG + LL G + F G + + L+ + Sbjct: 229 YYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMD------------------ 270 Query: 262 LPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 314 S F G + D + ++L+ D + R++ +AL H + + + P Sbjct: 271 ---------DSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAP 314 >3PFQ-A nrPDB Length = 674 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 45/139 (32%), Positives = 77/139 (55%), Gaps = 5/139 (3%) Query: 103 YLVTTLMGADL-NNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED 161 +++ + G DL +I + + H F ++ GL ++ S GII+RDLK NV ++ + Sbjct: 419 FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 478 Query: 162 CELRILDFGLARQA--DEEMT-GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ 218 ++I DFG+ ++ D T + T Y APEI + + Y ++VD W+ G ++ E+L Sbjct: 479 GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI-IAYQPYGKSVDWWAFGVLLYEMLA 537 Query: 219 GKALFPGSDYIDQLKRIME 237 G+A F G D + + IME Sbjct: 538 GQAPFEGEDEDELFQSIME 556 >3LLT-A nrPDB Length = 360 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 56/225 (24%), Positives = 100/225 (44%), Gaps = 43/225 (19%) Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNE------------------------ 160 E ++ ++L+ L Y+ + H DLKP N+ +++ Sbjct: 137 EDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRT 196 Query: 161 -DCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQG 219 ++++DFG A + + TR YRAPE++LN + ++ + D+WS GC++AEL G Sbjct: 197 KSTGIKLIDFGCATFKSDYHGSIINTRQYRAPEVILN-LGWDVSSDMWSFGCVLAELYTG 255 Query: 220 KALFPGSDYIDQLKRIMEVVGTPSPE-VLAKISSEHARTYIQS-----LPPMPQKDLSSI 273 LF ++++ L +ME + P P+ +L + + + Y+ P ++SI Sbjct: 256 SLLFRTHEHMEHLA-MMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSI 314 Query: 274 --FRGANP--------LAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 + P L D L +L +D R S AE L H + Sbjct: 315 KHVKKCLPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHKFL 359 >3EQC-A nrPDB Length = 360 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 49/161 (30%), Positives = 79/161 (49%), Gaps = 9/161 (5%) Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQF 129 REL++L ++G F I + + G L+ ++K E + Sbjct: 80 RELQVLHECNSPYIVGFYGAFYSDGEIS-----ICMEHMDGGSLDQVLKKAGRIPEQILG 134 Query: 130 LV-YQLLRGLKYIHSA-GIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM-TGYVATR 186 V +++GL Y+ I+HRD+KPSN+ VN E+++ DFG++ Q + M +V TR Sbjct: 135 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR 194 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD 227 Y +PE L HY+ DIWS+G + E+ G+ P D Sbjct: 195 SYMSPE-RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPD 234 >2I0E-A nrPDB Length = 353 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 45/139 (32%), Positives = 77/139 (55%), Gaps = 5/139 (3%) Query: 103 YLVTTLMGADL-NNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED 161 +++ + G DL +I + + H F ++ GL ++ S GII+RDLK NV ++ + Sbjct: 98 FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 157 Query: 162 CELRILDFGLARQA--DEEMT-GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ 218 ++I DFG+ ++ D T + T Y APEI + + Y ++VD W+ G ++ E+L Sbjct: 158 GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI-IAYQPYGKSVDWWAFGVLLYEMLA 216 Query: 219 GKALFPGSDYIDQLKRIME 237 G+A F G D + + IME Sbjct: 217 GQAPFEGEDEDELFQSIME 235 >5HI2-A nrPDB Length = 283 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 75/253 (29%), Positives = 132/253 (52%), Gaps = 40/253 (15%) Query: 18 WEVP--QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLL 75 WE+P Q G R +GSG++G+V Y + VAVK L+ P Q + A + E+ +L Sbjct: 15 WEIPDGQITVGQR-IGSGSFGTV---YKGKWHGDVAVKMLT-PQQ--LQAFKN--EVGVL 65 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFL--VY 132 + +H N++ + T ++ +VT G+ L + + E + + Sbjct: 66 RKTRHVNILLFMGYSTKP-------QLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIAR 118 Query: 133 QLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD--------EEMTGYVA 184 Q RG+ Y+H+ IIHRDLK +N+ ++ED ++I DFGLA E+++G + Sbjct: 119 QTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSIL 178 Query: 185 TRWYRAPEI--MLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVV--G 240 + APE+ M + Y+ D+++ G ++ EL+ G+ P S+ I+ +I+E+V G Sbjct: 179 ---WMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQ--LPYSN-INNRDQIIEMVGRG 232 Query: 241 TPSPEVLAKISSE 253 + SP+ L+K+ S Sbjct: 233 SLSPD-LSKVRSN 244 >5VO2-A nrPDB Length = 300 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 64/221 (28%), Positives = 110/221 (49%), Gaps = 27/221 (12%) Query: 14 NKTVWEVP-QRLQGLRPVGSGAYGSVCSAYDARLR-QKVAVKKLSRPFQSLIHARRTYRE 71 ++ +WEVP + + L+ VGSGA G+V + R ++VAVKK+ R +E Sbjct: 3 SEDLWEVPFEEILDLQWVGSGAQGAV---FLGRFHGEEVAVKKV-----------RDLKE 48 Query: 72 --LRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-QALSDEHVQ 128 ++ L+ LKH N+I V T A L+ L +++ + ++ + Sbjct: 49 TDIKHLRKLKHPNIITFKGVCTQAPCY-----CILMEFCAQGQLYEVLRAGRPVTPSLLV 103 Query: 129 FLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT--GYVATR 186 + G+ Y+H IIHRDLK N+ + D ++I DFG +++ ++ T + T Sbjct: 104 DWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTV 163 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD 227 + APE++ N ++ VDIWS G ++ ELL G+ + D Sbjct: 164 AWMAPEVIRN-EPVSEKVDIWSFGVVLWELLTGEIPYKDVD 203 >5GRN-A nrPDB Length = 356 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 72/247 (29%), Positives = 115/247 (46%), Gaps = 45/247 (18%) Query: 18 WEVPQRLQGL---RPVGSGAYGSVC--SAYDARLRQ---KVAVKKLSRPFQSLIHARRTY 69 WE P+ GL R +GSGA+G V +AY Q KVAVK L +P + Sbjct: 41 WEFPR--DGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKML-KPTARSSEKQALM 97 Query: 70 RELRLLKHLK-HENVIGLLDVFTPATSIEDFSEVYLVTTLMG---------------ADL 113 EL+++ HL H N++ LL T + I +E L+ + L Sbjct: 98 SELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSML 157 Query: 114 NNIVKCQALSDEHVQFLV--------YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELR 165 ++ VK LSD++ + L YQ+ RG++++ S +HRDL NV + + ++ Sbjct: 158 DSEVK-NLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVK 216 Query: 166 ILDFGLARQADEEM------TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ- 218 I DFGLAR + + ++ +W APE + + + Y D+WS G ++ E+ Sbjct: 217 ICDFGLARDIMHDSNYVSKGSTFLPVKW-MAPESIFDNL-YTTLSDVWSYGILLWEIFSL 274 Query: 219 GKALFPG 225 G +PG Sbjct: 275 GGTPYPG 281 >6GVJ-A nrPDB Length = 429 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 131/300 (43%), Gaps = 56/300 (18%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR-ELRLLKHLKH--ENV 83 L+ +GSG V + + +Q A+K ++ ++ +YR E+ L L+ + + Sbjct: 149 LKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLE-EADNQTLDSYRNEIAYLNKLQQHSDKI 206 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQ-LLRGLKYIH 142 I L D I D +Y+V DLN+ +K + D + ++ +L + IH Sbjct: 207 IRLYDY-----EITD-QYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIH 260 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY-----VATRWYRAPEIMLNW 197 GI+H DLKP+N + D L+++DFG+A Q + T V T Y PE + + Sbjct: 261 QHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDM 319 Query: 198 MHYNQT----------VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 247 + D+WS+GCI+ + GK P I+Q+ ++ ++ P+ E+ Sbjct: 320 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKT--PFQQIINQISKLHAIID-PNHEI- 375 Query: 248 AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 P +P+KDL D+L L D QR+S E LAH Y Sbjct: 376 -------------EFPDIPEKDLQ-----------DVLKCCLKRDPKQRISIPELLAHPY 411 >4YHJ-A nrPDB Length = 584 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 67/258 (25%), Positives = 112/258 (43%), Gaps = 16/258 (6%) Query: 28 RPVGSGAYGSVCSA-YDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 R +G G +G VC+ A + K + + E R+L+ ++ V+ L Sbjct: 191 RVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSL 250 Query: 87 LDVFTPATSIEDFSEVYLVTTLM-GADLN----NIVKCQALSDEHVQFLVYQLLRGLKYI 141 A + E + LV T+M G DL N+ ++ F +L GL+ + Sbjct: 251 ------AYAYETKDALCLVLTIMNGGDLKFHIYNLGN-PGFDEQRAVFYAAELCCGLEDL 303 Query: 142 HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE--EMTGYVATRWYRAPEIMLNWMH 199 I++RDLKP N+ +++ +RI D GLA + E + G V T Y APE++ N Sbjct: 304 QRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN-EK 362 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI 259 Y + D W +GC++ E++QG + F + + + + + + E K S + Sbjct: 363 YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICR 422 Query: 260 QSLPPMPQKDLSSIFRGA 277 L P K L GA Sbjct: 423 MLLTKNPSKRLGCRGEGA 440 >3TAC-A nrPDB Length = 361 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 127/300 (42%), Gaps = 58/300 (19%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLS-RPFQSL--IHARRTYRELRLLKHLKHENVIGL 86 +G G + V + Q+ AVK + F S + RE + LKH +++ L Sbjct: 34 IGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVEL 93 Query: 87 LDVFTPATSIEDFSEVYLVTTLM-GADL---------NNIVKCQALSDEHVQFLVYQLLR 136 L+ ++ + Y+V M GADL V +A++ +++ Q+L Sbjct: 94 LETYSSDGML------YMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMR----QILE 143 Query: 137 GLKYIHSAGIIHRDLKPSNVAV---NEDCELRILDFGLARQADEE---MTGYVATRWYRA 190 L+Y H IIHRD+KP V + +++ FG+A Q E G V T + A Sbjct: 144 ALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMA 203 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI 250 PE+ + Y + VD+W G I+ LL G F G+ +R+ E + Sbjct: 204 PEV-VKREPYGKPVDVWGCGVILFILLSGCLPFYGTK-----ERLFEGI----------- 246 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 I+ M + S I A DL+ RML+LD +R++ EAL H + + Sbjct: 247 --------IKGKYKMNPRQWSHISESAK----DLVRRMLMLDPAERITVYEALNHPWLKE 294 >3VN9-A nrPDB Length = 340 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 71/256 (27%), Positives = 120/256 (46%), Gaps = 30/256 (11%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 L+ + +G GAYG V Q +AVK++ S + RLL L Sbjct: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNS-------QEQKRLLMDLD---- 101 Query: 84 IGLLDVFTPAT-----SIEDFSEVYLVTTLMGADLNN-----IVKCQALSDEHVQFLVYQ 133 I + V P T ++ +V++ LM L+ I K Q + ++ + + Sbjct: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVS 161 Query: 134 LLRGLKYIHSA-GIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYV--ATRWYRA 190 +++ L+++HS +IHRD+KPSNV +N ++++ DFG++ + + + + Y A Sbjct: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 Query: 191 PEIM---LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 247 PE + LN Y+ DIWS+G M EL FP + +++ +VV PSP++ Sbjct: 222 PERINPELNQKGYSVKSDIWSLGITMIEL--AILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 Query: 248 A-KISSEHARTYIQSL 262 A K S+E Q L Sbjct: 280 ADKFSAEFVDFTSQCL 295 >5TUR-A nrPDB Length = 404 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 56/203 (27%), Positives = 100/203 (49%), Gaps = 13/203 (6%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRP----FQSLIHARRTYRELRLLKHLKH--ENV 83 +GSG +GSV S VA+K + + + L + R E+ LLK + V Sbjct: 135 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 194 Query: 84 IGLLDVFT-PATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 I LLD F P + + V L + I + AL +E + +Q+L +++ H Sbjct: 195 IRLLDWFERPDSFVLILERPEPVQDL----FDFITERGALQEELARSFFWQVLEAVRHCH 250 Query: 143 SAGIIHRDLKPSNVAVNED-CELRILDFGL-ARQADEEMTGYVATRWYRAPEIMLNWMHY 200 + G++HRD+K N+ ++ + EL+++DFG A D T + TR Y PE + ++ Sbjct: 251 NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYH 310 Query: 201 NQTVDIWSVGCIMAELLQGKALF 223 ++ +WS+G ++ +++ G F Sbjct: 311 GRSAAVWSLGILLYDMVCGDIPF 333 >1JPA-A nrPDB Length = 312 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 60/210 (28%), Positives = 96/210 (45%), Gaps = 38/210 (18%) Query: 30 VGSGAYGSVCSAYDARLRQK----VAVKKLSRPFQSLIHARRTY-RELRLLKHLKHENVI 84 +G+G +G VCS + +L K VA+K L + RR + E ++ H NVI Sbjct: 41 IGAGEFGEVCSGH-LKLPGKREIFVAIKTLKSGYTE--KQRRDFLSEASIMGQFDHPNVI 97 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLL-------R 136 L V T +T V ++T M L++ L QF V QL+ Sbjct: 98 HLEGVVTKSTP------VMIITEFMENGSLDSF-----LRQNDGQFTVIQLVGMLRGIAA 146 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT---------GYVATRW 187 G+KY+ +HRDL N+ VN + ++ DFGL+R +++ + G + RW Sbjct: 147 GMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW 206 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 APE + + + D+WS G +M E++ Sbjct: 207 -TAPE-AIQYRKFTSASDVWSYGIVMWEVM 234 >4WUA-A nrPDB Length = 401 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 96/366 (26%), Positives = 157/366 (42%), Gaps = 86/366 (23%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT-YRELRLLKHLKH- 80 R +R +G G + +V ++D + ++ VA+K + +S H T E+RLLK +++ Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVV----KSAEHYTETALDEIRLLKSVRNS 97 Query: 81 -------ENVIGLLDVFTPATSIEDFSEVYLVTTLMGADL-NNIVKC--QALSDEHVQFL 130 E V+ LLD F S + + + +V ++G L I+K Q L V+ + Sbjct: 98 DPNDPNREMVVQLLDDFK--ISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKI 155 Query: 131 VYQLLRGLKYIHS-AGIIHRDLKPSNV--AVNED-------------------------- 161 + Q+L+GL Y+H+ IIH D+KP N+ +VNE Sbjct: 156 IQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVS 215 Query: 162 ---------------------CELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHY 200 +++I D G A + T + TR YR+ E+++ Y Sbjct: 216 TAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIG-SGY 274 Query: 201 NQTVDIWSVGCIMAELLQGKALF---PGSDYI---DQLKRIMEVVG-TPSPEVLAKISSE 253 N DIWS C+ EL G LF G +Y D + I+E++G P ++A S+ Sbjct: 275 NTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSK 334 Query: 254 HART------YIQSLPPMPQKD-LSSIFRGANPLA---IDLLGRMLVLDSDQRVSAAEAL 303 T +I L P + L + + A D L ML L ++R +AAE L Sbjct: 335 EFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECL 394 Query: 304 AHAYFS 309 H + + Sbjct: 395 RHPWLN 400 >4GS6-A nrPDB Length = 315 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 80/313 (25%), Positives = 130/313 (41%), Gaps = 55/313 (17%) Query: 30 VGSGAYGSVCSAYDARLRQK-VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 VG GA+G VC A + R K VA+K++ +S + ELR L + H N++ L Sbjct: 17 VGRGAFGVVCKA---KWRAKDVAIKQI----ESESERKAFIVELRQLSRVNHPNIVKLYG 69 Query: 89 -VFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA----LSDEHVQFLVYQLLRGLKYIHS 143 P + +++E G L N++ + H Q +G+ Y+HS Sbjct: 70 ACLNPVCLVMEYAE--------GGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHS 121 Query: 144 ---AGIIHRDLKPSNVA-VNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMH 199 +IHRDLKP N+ V L+I DFG A MT + + APE+ + Sbjct: 122 MQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEG-SN 180 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI 259 Y++ D++S G I+ E++ + F + +G P+ ++ + + I Sbjct: 181 YSEKCDVFSWGIILWEVITRRKPF-------------DEIGGPAFRIMWAVHNGTRPPLI 227 Query: 260 QSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA-HAYFSQYHDPEDEP 318 ++LP K + S L+ R D QR S E + + +Y DEP Sbjct: 228 KNLP----KPIES-----------LMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEP 272 Query: 319 EAEPYDESVEAKE 331 P S+ E Sbjct: 273 LQYPCQHSLPPGE 285 >3FME-A nrPDB Length = 290 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 71/256 (27%), Positives = 122/256 (47%), Gaps = 30/256 (11%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 L+ + +G GAYG V Q +AVK++ S + RLL L Sbjct: 9 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNS-------QEQKRLLMDLD---- 57 Query: 84 IGLLDVFTPAT-----SIEDFSEVYLVTTLMGADLNN-----IVKCQALSDEHVQFLVYQ 133 I + V P T ++ +V++ LM L+ I K Q + ++ + + Sbjct: 58 ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVS 117 Query: 134 LLRGLKYIHSA-GIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYV--ATRWYRA 190 +++ L+++HS +IHRD+KPSNV +N ++++ DFG++ +++ + + Y A Sbjct: 118 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMA 177 Query: 191 PEIM---LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 247 PE + LN Y+ DIWS+G M EL + FP + +++ +VV PSP++ Sbjct: 178 PERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPSPQLP 235 Query: 248 A-KISSEHARTYIQSL 262 A K S+E Q L Sbjct: 236 ADKFSAEFVDFTSQCL 251 >5O0Y-A nrPDB Length = 579 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 100/213 (46%), Gaps = 28/213 (13%) Query: 35 YGSVCSAYDARLRQKVAVK-----KLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 + V A+D ++ VAVK K R + + + RE R+ K L H ++ L D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 90 FTPATSIEDFSEVYLVTTLMGADLNNIVKCQAL-SDEHVQFLVYQLLRGLKYIHSAG--I 146 F S++ S ++ G DL+ +K L S++ + ++ Q++ LKY++ I Sbjct: 357 F----SLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPI 412 Query: 147 IHRDLKPSNVAV--NEDC-ELRILDFGLARQADEEMTGYV----------ATRWYRAPEI 193 IH DLKP N+ + C E++I DFGL++ D++ V T WY PE Sbjct: 413 IHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPEC 472 Query: 194 MLNWMH---YNQTVDIWSVGCIMAELLQGKALF 223 + + VD+WSVG I + L G+ F Sbjct: 473 FVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF 505 >2UV2-A nrPDB Length = 325 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 50/210 (23%), Positives = 95/210 (45%), Gaps = 22/210 (10%) Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77 WE+ L G GA+G V A + A K + + + E+ +L Sbjct: 39 WEIIGEL------GDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV--EIDILAS 90 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC--QALSDEHVQFLVYQLL 135 H N++ LLD F ++ L+ G ++ ++ + L++ +Q + Q L Sbjct: 91 CDHPNIVKLLDAFYYENNL-----WILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTL 145 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM---TGYVATRWYRAPE 192 L Y+H IIHRDLK N+ D ++++ DFG++ + + ++ T ++ APE Sbjct: 146 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 205 Query: 193 IMLNWMH----YNQTVDIWSVGCIMAELLQ 218 +++ Y+ D+WS+G + E+ + Sbjct: 206 VVMCETSKDRPYDYKADVWSLGITLIEMAE 235 >3HMP-A nrPDB Length = 342 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 131/300 (43%), Gaps = 56/300 (18%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR-ELRLLKHLKH--ENV 83 L+ +GSG V + + +Q A+K ++ ++ +YR E+ L L+ + + Sbjct: 61 LKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLE-EADNQTLDSYRNEIAYLNKLQQHSDKI 118 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQ-LLRGLKYIH 142 I L D I D +Y+V DLN+ +K + D + ++ +L + IH Sbjct: 119 IRLYDY-----EITD-QYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIH 172 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY-----VATRWYRAPEIMLNW 197 GI+H DLKP+N + D L+++DFG+A Q + T V T Y PE + + Sbjct: 173 QHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDM 231 Query: 198 MHYNQT----------VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 247 + D+WS+GCI+ + GK P I+Q+ ++ ++ P+ E+ Sbjct: 232 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKT--PFQQIINQISKLHAII-DPNHEI- 287 Query: 248 AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 P +P+KDL D+L L D QR+S E LAH Y Sbjct: 288 -------------EFPDIPEKDLQ-----------DVLKCCLKRDPKQRISIPELLAHPY 323 >4RC3-A nrPDB Length = 289 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 56/203 (27%), Positives = 100/203 (49%), Gaps = 13/203 (6%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRP----FQSLIHARRTYRELRLLKHLK--HENV 83 +GSG +GSV S VA+K + + + L + R E+ LLK + V Sbjct: 20 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 79 Query: 84 IGLLDVFT-PATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 I LLD F P + + V L + I + AL +E + +Q+L +++ H Sbjct: 80 IRLLDWFERPDSFVLILERPEPVQDL----FDFITERGALQEELARSFFWQVLEAVRHCH 135 Query: 143 SAGIIHRDLKPSNVAVNED-CELRILDFGL-ARQADEEMTGYVATRWYRAPEIMLNWMHY 200 + G++HRD+K N+ ++ + EL+++DFG A D T + TR Y PE + ++ Sbjct: 136 NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYH 195 Query: 201 NQTVDIWSVGCIMAELLQGKALF 223 ++ +WS+G ++ +++ G F Sbjct: 196 GRSAAVWSLGILLYDMVCGDIPF 218 >3NYO-A nrPDB Length = 576 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 76/297 (25%), Positives = 126/297 (42%), Gaps = 46/297 (15%) Query: 28 RPVGSGAYGSVCSA-YDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 R +G G +G VC+ A + K + + E ++L+ + V+ L Sbjct: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 Query: 87 LDVFTPATSIEDFSEVYLVTTLM-GADLNNIV---KCQALSDEHVQFLVYQLLRGLKYIH 142 A + E + LV TLM G DL + + F ++ GL+ +H Sbjct: 250 ------AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT--GYVATRWYRAPEIMLNWMHY 200 I++RDLKP N+ +++ +RI D GLA E T G V T Y APE++ N Y Sbjct: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN-ERY 362 Query: 201 NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQ 260 + D W++GC++ E++ G++ F Q K+ KI E ++ Sbjct: 363 TFSPDWWALGCLLYEMIAGQSPF------QQRKK--------------KIKREEVERLVK 402 Query: 261 SLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEALAHAYFSQYH 312 +P ++ S F +P A L ++L D +R+ SA E H F + + Sbjct: 403 EVP----EEYSERF---SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 >4RA4-A nrPDB Length = 355 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 45/142 (31%), Positives = 75/142 (52%), Gaps = 11/142 (7%) Query: 103 YLVTTLMGADLN-NIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED 161 +++ + G DL +I + + F ++ GL ++H GII+RDLK NV ++ + Sbjct: 98 FVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSE 157 Query: 162 CELRILDFGLARQADEEMTGYVATRW------YRAPEIMLNWMHYNQTVDIWSVGCIMAE 215 ++I DFG+ + E M V TR Y APEI + + Y ++VD W+ G ++ E Sbjct: 158 GHIKIADFGMCK---EHMMDGVTTRTFCGTPDYIAPEI-IAYQPYGKSVDWWAYGVLLYE 213 Query: 216 LLQGKALFPGSDYIDQLKRIME 237 +L G+ F G D + + IME Sbjct: 214 MLAGQPPFDGEDEDELFQSIME 235 >2R2P-A nrPDB Length = 295 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 65/237 (27%), Positives = 104/237 (43%), Gaps = 35/237 (14%) Query: 28 RPVGSGAYGSVCSA---YDARLRQKVAVKKLSRPFQSLIHARRTY-RELRLLKHLKHENV 83 R +G+G +G VCS + VA+K L + RR + E ++ H N+ Sbjct: 28 RVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTE--KQRRDFLGEASIMGQFDHPNI 85 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLL------- 135 I L V T + V +VT M L+ +K QF V QL+ Sbjct: 86 IHLEGVVTKSKP------VMIVTEYMENGSLDTFLK-----KNDGQFTVIQLVGMLRGIS 134 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE-------MTGYVATRWY 188 G+KY+ G +HRDL N+ +N + ++ DFGL+R +++ G + RW Sbjct: 135 AGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW- 193 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSP 244 APE + + + D+WS G +M E++ G+ + D +K + E PSP Sbjct: 194 TAPE-AIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSP 249 >6NPU-A nrPDB Length = 298 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 59/240 (24%), Positives = 114/240 (47%), Gaps = 21/240 (8%) Query: 8 FYRQELNKTVWEVPQRLQGLR-PVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR 66 +++ N WE+ + ++ +G G YG V + VAVK L + + Sbjct: 11 YFQGSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVE 67 Query: 67 RTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKC--QAL 122 +E ++K +KH N++ LL V T Y++T M G L+ + +C Q + Sbjct: 68 EFLKEAAVMKEIKHPNLVQLLGVCTREPPF------YIITEFMTYGNLLDYLRECNRQEV 121 Query: 123 SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR-QADEEMTG 181 + + ++ Q+ ++Y+ IHRDL N V E+ +++ DFGL+R + T Sbjct: 122 NAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTA 181 Query: 182 YVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIME 237 + ++ + APE L + ++ D+W+ G ++ E+ G + +PG D + Q+ ++E Sbjct: 182 HAGAKFPIKWTAPE-SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLE 239 >5AP3-A nrPDB Length = 313 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 130/300 (43%), Gaps = 56/300 (18%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR-ELRLLKHLKH--ENV 83 L+ +GSG V + + +Q A+K ++ ++ +YR E+ L L+ + + Sbjct: 33 LKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLE-EADNQTLDSYRNEIAYLNKLQQHSDKI 90 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQ-LLRGLKYIH 142 I L D I D +Y+V DLN +K + D + ++ +L + IH Sbjct: 91 IRLYDY-----EITD-QYIYMVMECGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIH 144 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY-----VATRWYRAPEIMLNW 197 GI+H DLKP+N + D L+++DFG+A Q + T V T Y PE + + Sbjct: 145 QHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDM 203 Query: 198 MHYNQT----------VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 247 + D+WS+GCI+ + GK P I+Q+ ++ ++ P+ E+ Sbjct: 204 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKT--PFQQIINQISKLHAII-DPNHEI- 259 Query: 248 AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 P +P+KDL D+L L D QR+S E LAH Y Sbjct: 260 -------------EFPDIPEKDLQ-----------DVLKCCLKRDPKQRISIPELLAHPY 295 >3BGP-A nrPDB Length = 333 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 56/203 (27%), Positives = 100/203 (49%), Gaps = 13/203 (6%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRP----FQSLIHARRTYRELRLLKHLK--HENV 83 +GSG +GSV S VA+K + + + L + R E+ LLK + V Sbjct: 64 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 123 Query: 84 IGLLDVFT-PATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 I LLD F P + + V L + I + AL +E + +Q+L +++ H Sbjct: 124 IRLLDWFERPDSFVLILERPEPVQDL----FDFITERGALQEELARSFFWQVLEAVRHCH 179 Query: 143 SAGIIHRDLKPSNVAVNED-CELRILDFGL-ARQADEEMTGYVATRWYRAPEIMLNWMHY 200 + G++HRD+K N+ ++ + EL+++DFG A D T + TR Y PE + ++ Sbjct: 180 NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYH 239 Query: 201 NQTVDIWSVGCIMAELLQGKALF 223 ++ +WS+G ++ +++ G F Sbjct: 240 GRSAAVWSLGILLYDMVCGDIPF 262 >5X5O-A nrPDB Length = 310 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 95/206 (46%), Gaps = 17/206 (8%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 LQ G G++GSV A ++VAVKKL + +E +L L H N+ Sbjct: 17 LQFFENCGGGSFGSVYRAKWISQDKEVAVKKL----------LKIEKEAEILSVLSHRNI 66 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHS 143 I V + +E + +L D N + + + +H+ + +G+ Y+H Sbjct: 67 IQFYGVILEPPNYGIVTEYASLGSLY--DYINSNRSEEMDMDHIMTWATDVAKGMHYLHM 124 Query: 144 AG---IIHRDLKPSNVAVNEDCELRILDFGLARQADEEM-TGYVATRWYRAPEIMLNWMH 199 +IHRDLK NV + D L+I DFG +R + V T + APE++ + + Sbjct: 125 EAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS-LP 183 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPG 225 ++T D +S G ++ E+L + F G Sbjct: 184 VSETCDTYSYGVVLWEMLTREVPFKG 209 >4XEY-B nrPDB Length = 408 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 56/217 (25%), Positives = 104/217 (47%), Gaps = 20/217 (9%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G G YG V + VAVK L + + +E ++K +KH N++ LL V Sbjct: 133 LGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLGV 189 Query: 90 FTPATSIEDFSEVYLVTTLM--GADLNNIVKC--QALSDEHVQFLVYQLLRGLKYIHSAG 145 T Y++T M G L+ + +C Q ++ + ++ Q+ ++Y+ Sbjct: 190 CTREPPF------YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKN 243 Query: 146 IIHRDLKPSNVAVNEDCELRILDFGLAR-QADEEMTGYVATRW---YRAPEIMLNWMHYN 201 IHRDL N V E+ +++ DFGL+R + T + ++ + APE L + ++ Sbjct: 244 FIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE-SLAYNKFS 302 Query: 202 QTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIME 237 D+W+ G ++ E+ G + +PG D + Q+ ++E Sbjct: 303 IKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLE 338 >3BEA-A nrPDB Length = 333 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 63/232 (27%), Positives = 107/232 (46%), Gaps = 27/232 (11%) Query: 18 WEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLS-RPFQSLIHARRT---YREL 72 WE P+ LQ + +G+GA+G V A L ++ AV K++ + +S HA EL Sbjct: 41 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSEL 100 Query: 73 RLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMG----------ADLNNIVKCQA 121 +++ HL +HEN++ LL T + +E L+ D + Sbjct: 101 KIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANST 160 Query: 122 LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTG 181 LS + Q+ +G+ ++ S IHRD+ NV + +I DFGLAR + + Sbjct: 161 LSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND-SN 219 Query: 182 YVA-------TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPG 225 Y+ +W APE + + ++ Q+ D+WS G ++ E+ G +PG Sbjct: 220 YIVKGNARLPVKW-MAPESIFDCVYTVQS-DVWSYGILLWEIFSLGLNPYPG 269 >5KCV-A nrPDB Length = 460 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 52/211 (24%), Positives = 106/211 (50%), Gaps = 18/211 (8%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR----RTYRELRLLKHLKHEN 82 L+ +G G +G V + + A+K L + +I A+ T E R+L++ +H Sbjct: 167 LKLLGKGTFGKVILVKEKATGRYYAMKILKK---EVIVAKDEVAHTLTENRVLQNSRHPF 223 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLN-NIVKCQALSDEHVQFLVYQLLRGLKYI 141 + L F + +++ G +L ++ + + S++ +F +++ L Y+ Sbjct: 224 LTALKYSFQTHDRL-----CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 278 Query: 142 HS-AGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE---MTGYVATRWYRAPEIMLNW 197 HS +++RDLK N+ +++D ++I DFGL ++ ++ M + T Y APE++ + Sbjct: 279 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED- 337 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDY 228 Y + VD W +G +M E++ G+ F D+ Sbjct: 338 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 368 >3ORP-A nrPDB Length = 311 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 98/213 (46%), Gaps = 28/213 (13%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR------RTYRELRLLKHLKHENV 83 +G G V A D R + VAVK L AR R RE + L H + Sbjct: 20 LGFGGMSEVHLARDLRDHRDVAVKVLRADL-----ARDPSFYLRFRREAQNAAALNHPAI 74 Query: 84 IGLLDVF---TPATSIEDFSEVYLVTTLM-GADLNNIVKCQA-LSDEHVQFLVYQLLRGL 138 + + D TPA + Y+V + G L +IV + ++ + ++ + L Sbjct: 75 VAVYDTGEAETPAGPLP-----YIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQAL 129 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ-ADE-----EMTGYVATRWYRAPE 192 + H GIIHRD+KP+N+ ++ ++++DFG+AR AD + + T Y +PE Sbjct: 130 NFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPE 189 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG 225 + D++S+GC++ E+L G+ F G Sbjct: 190 -QARGDSVDARSDVYSLGCVLYEVLTGEPPFTG 221 >3MV5-A nrPDB Length = 342 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 52/211 (24%), Positives = 106/211 (50%), Gaps = 18/211 (8%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR----RTYRELRLLKHLKHEN 82 L+ +G G +G V + + A+K L + +I A+ T E R+L++ +H Sbjct: 15 LKLLGKGTFGKVILVKEKATGRYYAMKILKK---EVIVAKDEVAHTLTENRVLQNSRHPF 71 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLN-NIVKCQALSDEHVQFLVYQLLRGLKYI 141 + L F + +++ G +L ++ + + S++ +F +++ L Y+ Sbjct: 72 LTALKYSFQTHDRL-----CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 126 Query: 142 HS-AGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE---MTGYVATRWYRAPEIMLNW 197 HS +++RDLK N+ +++D ++I DFGL ++ ++ M + T Y APE++ + Sbjct: 127 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED- 185 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDY 228 Y + VD W +G +M E++ G+ F D+ Sbjct: 186 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 216 >4E93-A nrPDB Length = 377 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 71/233 (30%), Positives = 106/233 (45%), Gaps = 31/233 (13%) Query: 30 VGSGAYGSVCSAYDARLRQK---VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 +G G +G V + RLR VAVK + A+ +E R+LK H N++ L Sbjct: 122 IGRGNFGEV---FSGRLRADNTLVAVKSCRETLPPDLKAK-FLQEARILKQYSHPNIVRL 177 Query: 87 LDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA--LSDEHVQFLVYQLLRGLKYIHS 143 + V T I Y+V L+ G D ++ + L + + +V G++Y+ S Sbjct: 178 IGVCTQKQPI------YIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLES 231 Query: 144 AGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTG-YVATRWYR-------APEIML 195 IHRDL N V E L+I DFG++R EE G Y A+ R APE L Sbjct: 232 KCCIHRDLAARNCLVTEKNVLKISDFGMSR---EEADGVYAASGGLRQVPVKWTAPE-AL 287 Query: 196 NWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVG-TPSPEV 246 N+ Y+ D+WS G ++ E G + +P Q + +E G P PE+ Sbjct: 288 NYGRYSSESDVWSFGILLWETFSLGASPYPNLSN-QQTREFVEKGGRLPCPEL 339 >6CTH-A nrPDB Length = 309 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 58/212 (27%), Positives = 103/212 (48%), Gaps = 19/212 (8%) Query: 19 EVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL 78 +V +G G +GSV + +AVKK+SR + I + E++++ L Sbjct: 12 KVTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGI--KEYASEVKIISRL 69 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQF-LVYQLL 135 +H+N++ L+ + E+ LV M G+ ++I K ++L V++ +V L Sbjct: 70 RHKNLVKLIGW------CHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLA 123 Query: 136 RGLKYIHSAG---IIHRDLKPSNVAVNEDCELRILDFGLARQADE----EMTGYVATRWY 188 L Y+H G ++HRD+K SN+ ++ ++ DFGLAR D + T T Y Sbjct: 124 SALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGY 183 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQGK 220 APE L+ ++ D++S G + E+ G+ Sbjct: 184 MAPEC-LSSGKASKESDVYSFGVVALEIASGR 214 >3C51-A nrPDB Length = 543 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 43/144 (29%), Positives = 76/144 (52%), Gaps = 10/144 (6%) Query: 89 VFTPATSIEDFSEVYLVTTLM-GADL-----NNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 + + A + E +++ LV T+M G D+ N + F Q++ GL+++H Sbjct: 247 IVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLH 306 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLA---RQADEEMTGYVATRWYRAPEIMLNWMH 199 II+RDLKP NV +++D +RI D GLA + + GY T + APE++L Sbjct: 307 QRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLG-EE 365 Query: 200 YNQTVDIWSVGCIMAELLQGKALF 223 Y+ +VD +++G + E++ + F Sbjct: 366 YDFSVDYFALGVTLYEMIAARGPF 389 >2OGV-A nrPDB Length = 317 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 64/233 (27%), Positives = 110/233 (47%), Gaps = 33/233 (14%) Query: 18 WEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLS-RPFQSLIHARRT---YREL 72 WE P+ LQ + +G+GA+G V A L ++ AV K++ + +S HA EL Sbjct: 33 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSEL 92 Query: 73 RLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSD------- 124 +++ HL +HEN++ LL T + +E DL N ++ +A +D Sbjct: 93 KIMSHLGQHENIVNLLGACTHGGPVLVITEYCCY-----GDLLNFLRRKAEADLDKEDGR 147 Query: 125 ----EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT 180 + Q+ +G+ ++ S IHRD+ NV + +I DFGLAR + + Sbjct: 148 PLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND-S 206 Query: 181 GYVA-------TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPG 225 Y+ +W APE + + ++ Q+ D+WS G ++ E+ G +PG Sbjct: 207 NYIVKGNARLPVKW-MAPESIFDCVYTVQS-DVWSYGILLWEIFSLGLNPYPG 257 >2W1I-A nrPDB Length = 326 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 99/209 (47%), Gaps = 20/209 (9%) Query: 22 QRLQGLRPVGSGAYGSV-CSAYDA---RLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77 + L+ L+ +G G +GSV YD + VAVKKL + H R RE+ +LK Sbjct: 41 RHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE--HLRDFEREIEILKS 98 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVY--QLL 135 L+H+N++ V A + ++ L L + ++ +H++ L Y Q+ Sbjct: 99 LQHDNIVKYKGVCYSAGRR---NLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQIC 155 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATR-------WY 188 +G++Y+ + IHRDL N+ V + ++I DFGL + ++ Y WY Sbjct: 156 KGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY 215 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 APE L ++ D+WS G ++ EL Sbjct: 216 -APE-SLTESKFSVASDVWSFGVVLYELF 242 >2ZMD-A nrPDB Length = 390 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 60/222 (27%), Positives = 97/222 (43%), Gaps = 45/222 (20%) Query: 102 VYLVTTLMGADLNNIVKCQALSDEHVQFLVYQ-LLRGLKYIHSAGIIHRDLKPSNVAVNE 160 +Y+V DLN+ +K + D + ++ +L + IH GI+H DLKP+N + Sbjct: 131 IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-V 189 Query: 161 DCELRILDFGLARQADEEMTGYVATRW-----YRAPEIMLNWMHYNQT----------VD 205 D L+++DFG+A Q + T V Y PE + + + D Sbjct: 190 DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSSSRENGKSKSKISPKSD 249 Query: 206 IWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPM 265 +WS+GCI+ + GK P I+Q+ ++ ++ P+ E+ P + Sbjct: 250 VWSLGCILYYMTYGKT--PFQQIINQISKLHAII-DPNHEI--------------EFPDI 292 Query: 266 PQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 P+KDL D+L L D QR+S E LAH Y Sbjct: 293 PEKDLQ-----------DVLKCCLKRDPKQRISIPELLAHPY 323 >3UDB-A nrPDB Length = 317 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 51/205 (24%), Positives = 91/205 (44%), Gaps = 11/205 (5%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 R + ++ +G+G +G D + + VAVK + R + RE+ + L+H N Sbjct: 20 RYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKI---DENVKREIINHRSLRHPN 76 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 ++ +V T + + + G I S++ +F QL+ G+ Y H Sbjct: 77 IVRFKEVILTPTHLA----IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAH 132 Query: 143 SAGIIHRDLKPSNVAVNED--CELRILDFGLARQA--DEEMTGYVATRWYRAPEIMLNWM 198 + + HRDLK N ++ L+I DFG ++ + + V T Y APE++L Sbjct: 133 AMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKE 192 Query: 199 HYNQTVDIWSVGCIMAELLQGKALF 223 + + D+WS G + +L G F Sbjct: 193 YDGKVADVWSCGVTLYVMLVGAYPF 217 >6HXF-B nrPDB Length = 302 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 60/249 (24%), Positives = 116/249 (46%), Gaps = 26/249 (10%) Query: 10 RQELN-KTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT 68 R++L+ VWE+ L G GA+G V A + A K + +S Sbjct: 12 RRDLDPNEVWEIVGEL------GDGAFGKVYKAKNKETGALAAAKVIET--KSEEELEDY 63 Query: 69 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--CQALSDEH 126 E+ +L H ++ LL + D ++ G ++ I+ + L++ Sbjct: 64 IVEIEILATCDHPYIVKLLGAY-----YHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQ 118 Query: 127 VQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT---GYV 183 +Q + Q+L L ++HS IIHRDLK NV + + ++R+ DFG++ + + + ++ Sbjct: 119 IQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFI 178 Query: 184 ATRWYRAPE-IMLNWMH---YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVV 239 T ++ APE +M M Y+ DIWS+G + E+ Q + P ++ ++ ++++ Sbjct: 179 GTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQ---IEPPHHELNPMRVLLKIA 235 Query: 240 GTPSPEVLA 248 + P +L Sbjct: 236 KSDPPTLLT 244 >5HIE-A nrPDB Length = 302 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 71/251 (28%), Positives = 127/251 (50%), Gaps = 36/251 (14%) Query: 18 WEVP--QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLL 75 WE+P Q G R +GSG++G+V Y + VAVK L+ P Q + A + E+ +L Sbjct: 31 WEIPDGQITVGQR-IGSGSFGTV---YKGKWHGDVAVKMLT-PQQ--LQAFKN--EVGVL 81 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFL--VY 132 + +H N++ + T ++ +VT G+ L + + E ++ + Sbjct: 82 RKTRHVNILLFMGYSTKP-------QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIAR 134 Query: 133 QLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD--------EEMTGYVA 184 Q +G+ Y+H+ IIHRDLK +N+ ++ED ++I DFGLA E+++G + Sbjct: 135 QTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSIL 194 Query: 185 TRWYRAPEI--MLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTP 242 + APE+ M + Y+ D+++ G ++ EL+ G+ + + DQ+ M G Sbjct: 195 ---WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQII-FMVGRGYL 250 Query: 243 SPEVLAKISSE 253 SP+ L+K+ S Sbjct: 251 SPD-LSKVRSN 260 >5HVK-A nrPDB Length = 315 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 96/209 (45%), Gaps = 31/209 (14%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTY-RELRLLKHLKHENVIGLLD 88 +G G +G + + +K+L R F +RT+ +E+++++ L+H NV+ + Sbjct: 22 LGKGCFGQAIKVTHRETGEVMVMKELIR-FDE--ETQRTFLKEVKVMRCLEHPNVLKFIG 78 Query: 89 VFTPATSIEDFSEVYLVTTLMGADLNNIVKC---QALSDEHVQFLVYQLLRGLKYIHSAG 145 V + ++ + G L I+K Q + V F + G+ Y+HS Sbjct: 79 VLYKDKRLN-----FITEYIKGGTLRGIIKSMDSQYPWSQRVSF-AKDIASGMAYLHSMN 132 Query: 146 IIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT-----------------GYVATRWY 188 IIHR+L N V E+ + + DFGLAR +E T V ++ Sbjct: 133 IIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYW 192 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 APE M+N Y++ VD++S G ++ E++ Sbjct: 193 MAPE-MINGRSYDEKVDVFSFGIVLCEII 220 >2XYN-A nrPDB Length = 292 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 61/240 (25%), Positives = 115/240 (47%), Gaps = 23/240 (9%) Query: 8 FYRQELNKTVWEVPQRLQGLR-PVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR 66 Y Q ++K WE+ + ++ +G G YG V + VAVK L + + Sbjct: 19 LYFQSMDK--WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK---EDTMEVE 73 Query: 67 RTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKC--QAL 122 +E ++K +KH N++ LL V T Y+VT M G L+ + +C + + Sbjct: 74 EFLKEAAVMKEIKHPNLVQLLGVCTLEPPF------YIVTEYMPYGNLLDYLRECNREEV 127 Query: 123 SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR-QADEEMTG 181 + + ++ Q+ ++Y+ IHRDL N V E+ +++ DFGL+R + T Sbjct: 128 TAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTA 187 Query: 182 YVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIME 237 + ++ + APE L + ++ D+W+ G ++ E+ G + +PG D + Q+ ++E Sbjct: 188 HAGAKFPIKWTAPE-SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYDLLE 245 >3IO7-A nrPDB Length = 313 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 63/221 (28%), Positives = 104/221 (47%), Gaps = 21/221 (9%) Query: 10 RQELNKTVWEVPQRLQGLRPVGSGAYGSV-CSAYDA---RLRQKVAVKKLSRPFQSLIHA 65 R N T +E + L+ L+ +G G +GSV YD + VAVKKL + H Sbjct: 17 RGSHNMTQFE-ERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE--HL 73 Query: 66 RRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDE 125 R RE+ +LK L+H+N++ V A + ++ L L + ++ + Sbjct: 74 RDFEREIEILKSLQHDNIVKYKGVCYSAGR---RNLKLIMEYLPYGSLRDYLQKHKERID 130 Query: 126 HVQFLVY--QLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYV 183 H++ L Y Q+ +G++Y+ + IHRDL N+ V + ++I DFGL + ++ Y Sbjct: 131 HIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYK 190 Query: 184 ATR-------WYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 WY APE L ++ D+WS G ++ EL Sbjct: 191 VKEPGESPIFWY-APE-SLTESKFSVASDVWSFGVVLYELF 229 >3DKO-A nrPDB Length = 318 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 64/236 (27%), Positives = 100/236 (42%), Gaps = 33/236 (13%) Query: 28 RPVGSGAYGSVCSA---YDARLRQKVAVKKLSRPFQSLIHARRTYR-ELRLLKHLKHENV 83 R +G+G +G VCS + VA+K L + RR + E ++ H NV Sbjct: 49 RVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTE--KQRRDFLCEASIMGQFDHPNV 106 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLL-------R 136 + L V T V +V M N L QF V QL+ Sbjct: 107 VHLEGVVTRGKP------VMIVIEFM----ENGALDAFLRKHDGQFTVIQLVGMLRGIAA 156 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE-------MTGYVATRWYR 189 G++Y+ G +HRDL N+ VN + ++ DFGL+R +++ G + RW Sbjct: 157 GMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRW-T 215 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSP 244 APE + + + D+WS G +M E++ G+ + D +K I E P+P Sbjct: 216 APE-AIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAP 270 >2FO0-A nrPDB Length = 495 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 104/217 (47%), Gaps = 20/217 (9%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G G YG V + VAVK L + + +E ++K +KH N++ LL V Sbjct: 225 LGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLGV 281 Query: 90 FTPATSIEDFSEVYLVTTLM--GADLNNIVKC--QALSDEHVQFLVYQLLRGLKYIHSAG 145 T Y++T M G L+ + +C Q ++ + ++ Q+ ++Y+ Sbjct: 282 CTREPPF------YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKN 335 Query: 146 IIHRDLKPSNVAVNEDCELRILDFGLAR-QADEEMTGYVATRW---YRAPEIMLNWMHYN 201 IHR+L N V E+ +++ DFGL+R + T + ++ + APE L + ++ Sbjct: 336 FIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE-SLAYNKFS 394 Query: 202 QTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIME 237 D+W+ G ++ E+ G + +PG D + Q+ ++E Sbjct: 395 IKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLE 430 >3TXO-A nrPDB Length = 353 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 64/247 (25%), Positives = 111/247 (44%), Gaps = 17/247 (6%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQSLIHARRTYRELRLLKHLK-HENVI 84 +R +G G++G V A AVK L + T E R+L + H + Sbjct: 28 IRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLT 87 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLMGADLN-NIVKCQALSDEHVQFLVYQLLRGLKYIHS 143 L F + +++ + G DL +I K + + +F +++ L ++H Sbjct: 88 QLFCCFQTPDRL-----FFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHD 142 Query: 144 AGIIHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYRAPEIMLNWMHY 200 GII+RDLK NV ++ + ++ DFG+ ++ + T Y APEI L M Y Sbjct: 143 KGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEI-LQEMLY 201 Query: 201 NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM--EVVGTPSPEVLAKISSEHARTY 258 VD W++G ++ E+L G A F + D + I+ EVV P L + ++ +++ Sbjct: 202 GPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVV---YPTWLHEDATGILKSF 258 Query: 259 IQSLPPM 265 + P M Sbjct: 259 MTKNPTM 265 >3G0E-A nrPDB Length = 336 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 71/268 (26%), Positives = 115/268 (42%), Gaps = 42/268 (15%) Query: 18 WEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQK-----VAVKKLSRPFQSLIHARRTYRE 71 WE P+ RL + +G+GA+G V A L + VAVK L +P L E Sbjct: 41 WEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKML-KPSAHLTEREALMSE 99 Query: 72 LRLLKHL-KHENVIGLLDVFT---PATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127 L++L +L H N++ LL T P I ++ + + ++ + C S + Sbjct: 100 LKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFI-CSKTSPAIM 158 Query: 128 QF------------LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA 175 + YQ+ +G+ ++ S IHRDL N+ + +I DFGLAR Sbjct: 159 EDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI 218 Query: 176 DEEMTGYVA-------TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSD 227 + + YV +W APE + N + Y D+WS G + EL G + +PG Sbjct: 219 KND-SNYVVKGNARLPVKW-MAPESIFNCV-YTFESDVWSYGIFLWELFSLGSSPYPGMP 275 Query: 228 YIDQLKRIMEVVGTPSPEVLAKISSEHA 255 + ++++ E +S EHA Sbjct: 276 VDSKFYKMIK-------EGFRMLSPEHA 296 >4Y83-A nrPDB Length = 332 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 55/218 (25%), Positives = 104/218 (47%), Gaps = 22/218 (10%) Query: 10 RQELNKTVWEVPQRLQGLRPVGS-----GAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH 64 R +++ V +P +L R +GS GA+G V A D + ++++A K + P Sbjct: 57 RYQIDSDVLLIPWKLT-YRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLI--PVDQFKP 113 Query: 65 ARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSD 124 + ++ + +HEN+ L ++ F E G+ L + C + + Sbjct: 114 S-----DVEIQACFRHENIAELYGAVLWGETVHLFME----AGEGGSVLEKLESCGPMRE 164 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM---TG 181 + ++ +L+GL ++HS +IH D+KPSN+ V + ++DFGL+ Q E++ Sbjct: 165 FEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNI-VFMSTKAVLVDFGLSVQMTEDVYFPKD 223 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQG 219 T Y +PE++L H + DI+S+G + + G Sbjct: 224 LRGTEIYMSPEVILCRGHSTKA-DIYSLGATLIHMQTG 260 >5VD3-A nrPDB Length = 311 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 72/255 (28%), Positives = 107/255 (41%), Gaps = 26/255 (10%) Query: 22 QRLQGLRPVGSGAYGSVC---SAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL 78 Q Q L +G G+YG V S D RL AVK+ PF+ R E+ Sbjct: 57 QSFQRLSRLGHGSYGEVFKVRSKEDGRL---YAVKRSMSPFRGPKDRARKLAEVG----- 108 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLR-- 136 HE V + E+ +YL T L G L C+A + V+ LR Sbjct: 109 SHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQ--HCEAWGASLPEAQVWGYLRDT 166 Query: 137 --GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYV--ATRWYRAPE 192 L ++HS G++H D+KP+N+ + ++ DFGL + G V Y APE Sbjct: 167 LLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPE 226 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 ++ Y D++S+G + E+ L G + QL++ G PE A +SS Sbjct: 227 LLQG--SYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQ-----GYLPPEFTAGLSS 279 Query: 253 EHARTYIQSLPPMPQ 267 E + L P P+ Sbjct: 280 ELRSVLVMMLEPDPK 294 >3ZUT-A nrPDB Length = 362 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 51/205 (24%), Positives = 90/205 (43%), Gaps = 11/205 (5%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 R + ++ +GSG +G D + + VAVK + R + RE+ + L+H N Sbjct: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI---DENVKREIINHRSLRHPN 76 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 ++ +V T + + + G I S++ +F QL+ G+ Y H Sbjct: 77 IVRFKEVILTPTHLA----IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH 132 Query: 143 SAGIIHRDLKPSNVAVNED--CELRILDFGLARQA--DEEMTGYVATRWYRAPEIMLNWM 198 + + HRDLK N ++ L+I FG ++ + + V T Y APE++L Sbjct: 133 AMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 Query: 199 HYNQTVDIWSVGCIMAELLQGKALF 223 + + D+WS G + +L G F Sbjct: 193 YDGKVADVWSCGVTLYVMLVGAYPF 217 >2A1A-B nrPDB Length = 284 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 72/266 (27%), Positives = 120/266 (45%), Gaps = 37/266 (13%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVI---GL 86 +GSG +G V A R+ K V K + + + RE++ L L H N++ G Sbjct: 19 IGSGGFGQVFKA-KHRIDGKTYVIKRVK-----YNNEKAEREVKALAKLDHVNIVHYNGC 72 Query: 87 LDVFT--PATSIEDFSEVY---LVTTLMGADLNNI------VKCQALSDEHVQFLVYQLL 135 D F P TS ++ S L + D + + + L L Q+ Sbjct: 73 WDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQIT 132 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR--QADEEMTGYVATRWYRAPEI 193 +G+ YIHS +I+RDLKPSN+ + + +++I DFGL + D + T T Y +PE Sbjct: 133 KGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPE- 191 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 ++ Y + VD++++G I+AELL F S + L+ +++ I Sbjct: 192 QISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLR----------DGIISDIFD 241 Query: 253 EHARTYIQSL---PPMPQKDLSSIFR 275 + +T +Q L P + + S I R Sbjct: 242 KKEKTLLQKLLSKKPEDRPNTSEILR 267 >1TKI-A nrPDB Length = 321 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 70/290 (24%), Positives = 126/290 (43%), Gaps = 48/290 (16%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVK--KLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 +G G +G V + ++ K K+ Q L+ +E+ +L +H N++ L Sbjct: 13 LGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVK-----KEISILNIARHRNILHLH 67 Query: 88 DVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA--LSDEHVQFLVYQLLRGLKYIHSAG 145 + F S+E+ V + + G D+ + A L++ + V+Q+ L+++HS Sbjct: 68 ESFE---SMEEL--VMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHN 122 Query: 146 IIHRDLKPSNVA--VNEDCELRILDFGLARQ---ADEEMTGYVATRWYRAPEIMLNWMHY 200 I H D++P N+ ++I++FG ARQ D + A +Y APE+ + + Sbjct: 123 IGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYY-APEVHQHDV-V 180 Query: 201 NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQ 260 + D+WS+G ++ LL G F ++ IM T E +IS E Sbjct: 181 STATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIE------- 233 Query: 261 SLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 A+D + R+LV + R++A+EAL H + Q Sbjct: 234 --------------------AMDFVDRLLVKERKSRMTASEALQHPWLKQ 263 >4P5Q-A nrPDB Length = 361 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 94/210 (44%), Gaps = 34/210 (16%) Query: 28 RPVGSGAYGSVCSA---YDARLRQKVAVKKLSRPFQSLIHARRTY-RELRLLKHLKHENV 83 + VG+G +G VCS ++ VA+K L + RR + E ++ H N+ Sbjct: 39 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTE--KQRRDFLGEASIMGQFDHPNI 96 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLL------- 135 I L V T + V +VT M L++ L QF V QL+ Sbjct: 97 IRLEGVVTKS------KPVMIVTEYMENGSLDSF-----LRKHDAQFTVIQLVGMLRGIA 145 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE-------MTGYVATRWY 188 G+KY+ G +HRDL N+ +N + ++ DFGL+R +++ G + RW Sbjct: 146 SGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW- 204 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQ 218 +PE + + + D+WS G ++ E++ Sbjct: 205 TSPE-AIAYRKFTSASDVWSYGIVLWEVMS 233 >3UIU-A nrPDB Length = 306 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 47/152 (30%), Positives = 78/152 (51%), Gaps = 17/152 (11%) Query: 130 LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR--QADEEMTGYVATRW 187 L Q+ +G+ YIHS +IHRDLKPSN+ + + +++I DFGL + D + T T Sbjct: 141 LFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLR 200 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEV 246 Y +PE ++ Y + VD++++G I+AELL F S + L+ + Sbjct: 201 YMSPE-QISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLR----------DGI 249 Query: 247 LAKISSEHARTYIQSL---PPMPQKDLSSIFR 275 ++ I + +T +Q L P + + S I R Sbjct: 250 ISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 281 >2X7G-A nrPDB Length = 389 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 92/374 (24%), Positives = 151/374 (40%), Gaps = 104/374 (27%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT-YRELRLLKHLKHE 81 R +R +G G + +V +D + ++ VA+K + +S H T E++LLK ++ Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVV----KSAQHYTETALDEIKLLKCVRES 87 Query: 82 N--------VIGLLDVFTPATSIEDFSEVYLVTTLMGADL-NNIVKC--QALSDEHVQFL 130 + V+ L+D F S + V +V ++G L I+K Q L V+ + Sbjct: 88 DPSDPNKDMVVQLIDDFK--ISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSI 145 Query: 131 VYQLLRGLKYIHS-AGIIHRDLKPSNVAVNED---------------------------- 161 + Q+L+GL Y+HS IIH D+KP N+ + D Sbjct: 146 IRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVS 205 Query: 162 -------------------CELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQ 202 ++I D G A + T + TR YR+ E+++ Y+ Sbjct: 206 TAPAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIG-AGYST 264 Query: 203 TVDIWSVGCIMAELLQGKALF---PGSDYI---DQLKRIMEVVGTPSPEVLAKISSEHAR 256 DIWS C+ EL G LF G DY D + I+E++G+ P A +S +++R Sbjct: 265 PADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGS-IPRHFA-LSGKYSR 322 Query: 257 TY---------IQSLPP------------MPQKDLSSIFRGANPLAIDLLGRMLVLDSDQ 295 + I L P P +D + D L ML + ++ Sbjct: 323 EFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQF--------TDFLIPMLEMVPEK 374 Query: 296 RVSAAEALAHAYFS 309 R SA E L H + + Sbjct: 375 RASAGECLRHPWLN 388 >5L6P-A nrPDB Length = 298 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 91/211 (43%), Gaps = 40/211 (18%) Query: 30 VGSGAYGSVCSAYDARLRQK------VAVKKLSRPFQSLIHARRTY-RELRLLKHLKHEN 82 +G+G +G VC RL+Q VA+K L + RR + E ++ H N Sbjct: 27 IGAGEFGEVCRG---RLKQPGRREVFVAIKTLKVGYTE--RQRRDFLSEASIMGQFDHPN 81 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLL------- 135 +I L V T + + +E + N L QF V QL+ Sbjct: 82 IIRLEGVVTKSRPVMILTEF----------MENCALDSFLRLNDGQFTVIQLVGMLRGIA 131 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE---------MTGYVATR 186 G+KY+ +HRDL N+ VN + ++ DFGL+R +++ + G + R Sbjct: 132 AGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIR 191 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 W APE + + + D+WS G +M E++ Sbjct: 192 W-TAPE-AIAYRKFTSASDVWSYGIVMWEVM 220 >3KRL-A nrPDB Length = 335 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 64/239 (26%), Positives = 109/239 (45%), Gaps = 39/239 (16%) Query: 18 WEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLS-RPFQSLIHARRT---YREL 72 WE P+ LQ + +G+GA+G V A L ++ AV K++ + +S HA EL Sbjct: 41 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSEL 100 Query: 73 RLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC------------ 119 +++ HL +HEN++ LL T + +E DL N ++ Sbjct: 101 KIMSHLGQHENIVNLLGACTHGGPVLVITEYCCY-----GDLLNFLRRKRPPGLEYSYNP 155 Query: 120 -----QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ 174 + LS + Q+ +G+ ++ S IHRD+ NV + +I DFGLAR Sbjct: 156 SHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARD 215 Query: 175 ADEEMTGYVA-------TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPG 225 + + Y+ +W APE + + ++ Q+ D+WS G ++ E+ G +PG Sbjct: 216 IMND-SNYIVKGNARLPVKW-MAPESIFDCVYTVQS-DVWSYGILLWEIFSLGLNPYPG 271 >1K9A-A nrPDB Length = 450 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 64/244 (26%), Positives = 118/244 (48%), Gaps = 22/244 (9%) Query: 10 RQELNKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT 68 + E ++ W + + L+ L+ +G G +G V D R KVAVK + ++ A+ Sbjct: 180 QDEFYRSGWALNMKELKLLQTIGKGEFGDVMLG-DYR-GNKVAVKCI----KNDATAQAF 233 Query: 69 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALS---- 123 E ++ L+H N++ LL V +E+ +Y+VT M L + ++ + S Sbjct: 234 LAEASVMTQLRHSNLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGG 288 Query: 124 DEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM-TGY 182 D ++F + + ++Y+ +HRDL NV V+ED ++ DFGL ++A TG Sbjct: 289 DCLLKFSL-DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK 347 Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGT 241 + +W APE L ++ D+WS G ++ E+ G+ +P D + R+ + Sbjct: 348 LPVKW-TAPE-ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKM 405 Query: 242 PSPE 245 +P+ Sbjct: 406 DAPD 409 >2RIO-A nrPDB Length = 434 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 76/316 (24%), Positives = 137/316 (43%), Gaps = 76/316 (24%) Query: 30 VGSGAYGSVC--SAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK-HENVIGL 86 +G G+ G+V ++ R VAVK++ F + E++LL H NVI Sbjct: 23 LGYGSSGTVVFQGSFQGR---PVAVKRMLIDFCDI-----ALMEIKLLTESDDHPNVIR- 73 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQF--------LVYQLLRGL 138 + + + + F +Y+ L +L ++V+ + +SDE+++ L+ Q+ G+ Sbjct: 74 ---YYCSETTDRF--LYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGV 128 Query: 139 KYIHSAGIIHRDLKPSNVAVN-------------EDCELRILDFGLARQADEEMTGY--- 182 ++HS IIHRDLKP N+ V+ E+ + I DFGL ++ D + + Sbjct: 129 AHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTN 188 Query: 183 ----VATRWYRAPEI------MLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQL 232 T +RAPE+ + +++DI+S+GC+ +L K P D + Sbjct: 189 LNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYIL-SKGKHPFGDKYSRE 247 Query: 233 KRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLD 292 I+ + + L ++ H R+ I A DL+ +M+ D Sbjct: 248 SNIIRGIFS-----LDEMKCLHDRSLIAE-------------------ATDLISQMIDHD 283 Query: 293 SDQRVSAAEALAHAYF 308 +R +A + L H F Sbjct: 284 PLKRPTAMKVLRHPLF 299 >3OMV-A nrPDB Length = 307 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 70/271 (25%), Positives = 126/271 (46%), Gaps = 46/271 (16%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVK--KLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 +GSG++G+V Y + VAVK K+ P A R E+ +L+ +H N++ + Sbjct: 44 IGSGSFGTV---YKGKWHGDVAVKILKVVDPTPEQFQAFRN--EVAVLRKTRHVNILLFM 98 Query: 88 DVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFL--VYQLLRGLKYIHSA 144 T + +VT G+ L + Q + Q + Q +G+ Y+H+ Sbjct: 99 GYMTK-------DNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAK 151 Query: 145 GIIHRDLKPSNVAVNEDCELRILDFGLA--------RQADEEMTGYVATRWYRAPEI--M 194 IIHRD+K +N+ ++E ++I DFGLA Q E+ TG V + APE+ M Sbjct: 152 NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVL---WMAPEVIRM 208 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG------------TP 242 + ++ D++S G ++ EL+ G+ + +I+ +I+ +VG Sbjct: 209 QDNNPFSFQSDVYSYGIVLYELMTGELPY---SHINNRDQIIFMVGRGYASPDLSKLYKN 265 Query: 243 SPEVLAKISSEHARTYIQSLPPMPQKDLSSI 273 P+ + ++ ++ + + P PQ LSSI Sbjct: 266 CPKAMKRLVADCVKKVKEERPLFPQI-LSSI 295 >4F9B-A nrPDB Length = 361 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 63/252 (25%), Positives = 105/252 (41%), Gaps = 70/252 (27%) Query: 120 QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDC-ELRILDFGLARQADE- 177 +LS + V+ + L + LK IH GI+HRD+KPSN N + ++DFGLA+ + Sbjct: 112 NSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDT 171 Query: 178 --EMTGYV----------------------------ATRWYRAPEIMLNWMHYNQTVDIW 207 E+ +V T +RAPE++ + +D+W Sbjct: 172 KIELLKFVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMW 231 Query: 208 SVGCIMAELLQGK-ALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSL---P 263 S G I LL G+ + SD + L +IM + G+ + + + A+T+ +S+ Sbjct: 232 SAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGS-------RETIQAAKTFGKSILCSK 284 Query: 264 PMPQKDLSSI---FRGANP----LAIDLLGRMLVLDS--------------------DQR 296 +P +DL + RG + L D+ G L+ R Sbjct: 285 EVPAQDLRKLCERLRGMDSSTPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASR 344 Query: 297 VSAAEALAHAYF 308 ++A EAL H +F Sbjct: 345 ITAEEALLHPFF 356 >4NEU-A nrPDB Length = 333 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 56/234 (23%), Positives = 107/234 (45%), Gaps = 28/234 (11%) Query: 32 SGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFT 91 SG +G V + R + + +K + + + H E +++ L+H V+ LL V Sbjct: 34 SGGFGKVSLCFH-RTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVI- 91 Query: 92 PATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQF-LVYQLLRGLKYIHSAGIIHRD 150 IE+ ++ + +L +++K + + V+ ++ +++ G+ Y+H G+IH+D Sbjct: 92 ----IEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKD 147 Query: 151 LKPSNVAVNEDCELRILDFGLA----------------RQADEEMTGYVATRWYRAPEIM 194 LKP N+ V+ D ++I D GLA R+ D T +Y APE Sbjct: 148 LKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPE-H 206 Query: 195 LNWMHYNQT--VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEV 246 LN ++ T D++S ++ + K P + I + + IM + P+V Sbjct: 207 LNDVNAKPTEKSDVYSFAVVLWAIFANKE--PYENAICEQQLIMCIKSGNRPDV 258 >2H34-A nrPDB Length = 309 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 71/224 (31%), Positives = 105/224 (46%), Gaps = 28/224 (12%) Query: 21 PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS-LIHARRTYRELRLLKHLK 79 P RL+ R VG G G V A D + VA+K +S S + R RE R L+ Sbjct: 35 PYRLR--RLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQ 92 Query: 80 HENVIGLLDVFTPATSIEDFSEV----YLVTTLM-GADLNNIVKCQA-LSDEHVQFLVYQ 133 +V+ I DF E+ Y+ L+ G DL +++ Q L+ +V Q Sbjct: 93 EPHVV----------PIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQ 142 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR-QADEEMT---GYVATRWYR 189 + L H+AG HRD+KP N+ V+ D ++DFG+A DE++T V T +Y Sbjct: 143 IGSALDAAHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYM 202 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLK 233 APE + H DI+++ C++ E L G + G DQL Sbjct: 203 APE-RFSESHATYRADIYALTCVLYECLTGSPPYQG----DQLS 241 >1BYG-A nrPDB Length = 278 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 62/231 (26%), Positives = 108/231 (46%), Gaps = 22/231 (9%) Query: 1 MSGPRAGFYRQELNKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPF 59 M G A + E ++ W + + L+ L+ +G G +G V D R KVAVK + Sbjct: 1 MGGSVAA--QDEFYRSGWALNMKELKLLQTIGKGEFGDVMLG-DYR-GNKVAVKCIKND- 55 Query: 60 QSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVK 118 A+ E ++ L+H N++ LL V +E+ +Y+VT M L + ++ Sbjct: 56 ---ATAQAFLAEASVMTQLRHSNLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLR 107 Query: 119 CQA---LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA 175 + L + + + ++Y+ +HRDL NV V+ED ++ DFGL ++A Sbjct: 108 SRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA 167 Query: 176 DEEM-TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFP 224 TG + +W APE L ++ D+WS G ++ E+ G+ +P Sbjct: 168 SSTQDTGKLPVKW-TAPE-ALREKKFSTKSDVWSFGILLWEIYSFGRVPYP 216 >6DBN-A nrPDB Length = 316 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 60/219 (27%), Positives = 98/219 (44%), Gaps = 43/219 (19%) Query: 24 LQGLRPVGSGAYGSV-CSAYDA---RLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 L+ +R +G G +G V YD ++VAVK L +P H +E+ +L++L Sbjct: 37 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSL-KPESGGNHIADLKKEIEILRNLY 95 Query: 80 HENV--------------IGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDE 125 HEN+ I L+ F P+ S++++ + + N I Q L Sbjct: 96 HENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEY---------LPKNKNKINLKQQLK-- 144 Query: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVAT 185 Q+ +G+ Y+ S +HRDL NV V + +++I DFGL + + + Y Sbjct: 145 ----YAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVK 200 Query: 186 R-------WYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 WY APE ++ Y + D+WS G + ELL Sbjct: 201 DDRDSPVFWY-APECLMQSKFYIAS-DVWSFGVTLHELL 237 >5MJB-A nrPDB Length = 305 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 90/211 (42%), Gaps = 40/211 (18%) Query: 30 VGSGAYGSVCSAYDARLRQK------VAVKKLSRPFQSLIHARRTY-RELRLLKHLKHEN 82 +G+G +G V Y RL+ VA+K L + RR + E ++ H N Sbjct: 34 IGAGEFGEV---YKGRLKLPGKREIYVAIKTLKAGYSE--KQRRDFLSEASIMGQFDHRN 88 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLL------- 135 +I L V T + V ++T M N L QF V QL+ Sbjct: 89 IIRLEGVVTKS------RPVMIITEFM----ENCALDSFLRQNDGQFTVIQLVGMLRGIA 138 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT---------GYVATR 186 G+KY+ +HRDL N+ VN + ++ DFGL+R ++ + G + R Sbjct: 139 AGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVR 198 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 W APE + + + D+WS G +M E++ Sbjct: 199 W-TAPE-AIAYRKFTSASDVWSYGIVMWEVM 227 >4XI2-A nrPDB Length = 446 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 52/207 (25%), Positives = 102/207 (49%), Gaps = 19/207 (9%) Query: 18 WEV-PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLK 76 WE+ P+ L L+ +G+G +G V R + VA+K + + + E +++ Sbjct: 182 WEIDPKDLTFLKELGTGQFGVVKYG-KWRGQYDVAIKMIR---EGSMSEDEFIEEAKVMM 237 Query: 77 HLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQ-ALSDEHVQFLVYQ 133 +L HE ++ L V T I +++T M G LN + + + + + + Sbjct: 238 NLSHEKLVQLYGVCTKQRPI------FIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD 291 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRW---YR 189 + ++Y+ S +HRDL N VN+ +++ DFGL+R D+E T V +++ + Sbjct: 292 VCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWS 351 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAEL 216 PE+++ + ++ DIW+ G +M E+ Sbjct: 352 PPEVLM-YSKFSSKSDIWAFGVLMWEI 377 >6BXI-A nrPDB Length = 333 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 69/272 (25%), Positives = 110/272 (40%), Gaps = 58/272 (21%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + + L+ +G GA+G V RL QK K + I + E + H++ E Sbjct: 6 EDFESLKVIGRGAFGEV------RLVQK---KDTGHVYAMKILRKADMLEKEQVGHIRAE 56 Query: 82 NVIGL----LDVFTPATSIEDFSEVYLVTTLM-GADLNNIV-KCQALSDEHVQFLVYQLL 135 I + L V S +D +YL+ + G D+ ++ K L++E QF + + + Sbjct: 57 RDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETV 116 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLA----------------------- 172 + IH G IHRD+KP N+ ++ +++ DFGL Sbjct: 117 LAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDF 176 Query: 173 ---------------RQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 R + V T Y APE+ + YN+ D WS+G IM E+L Sbjct: 177 TFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQ-TGYNKLCDWWSLGVIMYEML 235 Query: 218 QGKALFPGSDYIDQLKRIM---EVVGTPSPEV 246 G F + K++M E + P PEV Sbjct: 236 IGYPPFCSETPQETYKKVMNWKETLTFP-PEV 266 >3PLS-A nrPDB Length = 298 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 56/217 (25%), Positives = 95/217 (43%), Gaps = 24/217 (11%) Query: 28 RPVGSGAYGSVCSAY---DARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVI 84 R +G G +G V A+ R + A+K LSR + RE L++ L H NV+ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSR-ITEMQQVEAFLREGLLMRGLNHPNVL 85 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVY--QLLRGLKYIH 142 L+ + P + L+ + DL ++ + + + Q+ RG++Y+ Sbjct: 86 ALIGIMLPPEGLPHV----LLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLA 141 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRWYRAPEIMLNWM--- 198 +HRDL N ++E +++ DFGLAR D E Y + + +R + + W Sbjct: 142 EQKFVHRDLAARNCMLDESFTVKVADFGLARDILDRE---YYSVQQHRHARLPVKWTALE 198 Query: 199 -----HYNQTVDIWSVGCIMAELLQGKALFPGSDYID 230 + D+WS G ++ ELL A P +ID Sbjct: 199 SLQTYRFTTKSDVWSFGVLLWELLTRGA--PPYRHID 233 >3QD2-B nrPDB Length = 332 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 47/169 (27%), Positives = 80/169 (47%), Gaps = 31/169 (18%) Query: 71 ELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV-----KCQALSDE 125 ++R + +N +G L +P +VYL + N+ +C E Sbjct: 111 KIRRMDPFSTKNTVGQLQPSSP--------KVYLYIQMQLCRKENLKDWMNRRCSLEDRE 162 Query: 126 H--VQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE----- 178 H + Q+ ++++HS G++HRDLKPSN+ D +++ DFGL D++ Sbjct: 163 HGVCLHIFIQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQT 222 Query: 179 ----------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 TG V T+ Y +PE ++ +Y+ VDI+S+G I+ ELL Sbjct: 223 VLTPMPAYATHTGQVGTKLYMSPE-QIHGNNYSHKVDIFSLGLILFELL 270 >3PPZ-A nrPDB Length = 309 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 55/195 (28%), Positives = 100/195 (51%), Gaps = 15/195 (7%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT---YRELRLLKHLKHENVIGL 86 +G+G++G+V A VAVK L + HA R RE+ ++K L+H N++ Sbjct: 45 IGAGSFGTVHRA--EWHGSDVAVKIL---MEQDFHAERVNEFLREVAIMKRLRHPNIVLF 99 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAG- 145 + T ++ +E YL + L+ + L + + Y + +G+ Y+H+ Sbjct: 100 MGAVTQPPNLSIVTE-YLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNP 158 Query: 146 -IIHRDLKPSNVAVNEDCELRILDFGLAR-QADEEMTGYVA--TRWYRAPEIMLNWMHYN 201 I+HRDLK N+ V++ +++ DFGL+R +A ++ A T + APE++ + N Sbjct: 159 PIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRD-EPSN 217 Query: 202 QTVDIWSVGCIMAEL 216 + D++S G I+ EL Sbjct: 218 EKSDVYSFGVILWEL 232 >5TOS-A nrPDB Length = 395 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 63/229 (27%), Positives = 104/229 (45%), Gaps = 32/229 (13%) Query: 16 TVWEVPQRLQGLRP---VGSGAYGSVCSAY--DARLRQK-------VAVKKLSRPFQSLI 63 T E+ + RP +G G +G V + ++ L +AVKKL++ + Sbjct: 56 TFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQ 113 Query: 64 HARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADL-NNIVKCQAL 122 R E+ L L H N++ L+ +ED + + + L N++ + A Sbjct: 114 GHREWLTEINYLGQLSHPNLVKLI-----GYCLEDEHRLLVYEFMQKGSLENHLFRRGAY 168 Query: 123 SDEHVQFLVYQLL----RGLKYIHS--AGIIHRDLKPSNVAVNEDCELRILDFGLARQAD 176 FL + +GL ++HS +I+RD+K SN+ ++ D ++ DFGLAR Sbjct: 169 FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGP 228 Query: 177 EEMTGYVATR-----WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGK 220 YV+TR Y APE M + H N D++S G ++ E+L GK Sbjct: 229 MGDLSYVSTRVMGTYGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSGK 276 >6E4F-A nrPDB Length = 290 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 52/207 (25%), Positives = 102/207 (49%), Gaps = 19/207 (9%) Query: 18 WEV-PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLK 76 WE+ P+ L L+ +G+G +G V R + VA+K + + + E +++ Sbjct: 26 WEIDPKDLTFLKELGTGQFGVVKYG-KWRGQYDVAIKMIK---EGSMSEDEFIEEAKVMM 81 Query: 77 HLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQ-ALSDEHVQFLVYQ 133 +L HE ++ L V T I +++T M G LN + + + + + + Sbjct: 82 NLSHEKLVQLYGVCTKQRPI------FIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD 135 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRW---YR 189 + ++Y+ S +HRDL N VN+ +++ DFGL+R D+E T V +++ + Sbjct: 136 VCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWS 195 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAEL 216 PE+++ + ++ DIW+ G +M E+ Sbjct: 196 PPEVLM-YSKFSSKSDIWAFGVLMWEI 221 >4R7H-A nrPDB Length = 343 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 68/241 (28%), Positives = 113/241 (46%), Gaps = 36/241 (14%) Query: 18 WEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLS-RPFQSLIHARRT---YREL 72 WE P+ LQ + +G+GA+G V A L ++ AV K++ + +S HA EL Sbjct: 45 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSEL 104 Query: 73 RLLKHL-KHENVIGLLDVFT---PATSIEDF-------------SEVYLVTTLM-GADLN 114 +++ HL +HEN++ LL T P I ++ +E L +L G D Sbjct: 105 KIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPE 164 Query: 115 NIVKCQALSDEHVQFLVY--QLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLA 172 + K E L + Q+ +G+ ++ S IHRD+ NV + +I DFGLA Sbjct: 165 GLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLA 224 Query: 173 RQADEEMTGYVA-------TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFP 224 R + + Y+ +W APE + + ++ Q+ D+WS G ++ E+ G +P Sbjct: 225 RDIMND-SNYIVKGNARLPVKWM-APESIFDSVYTVQS-DVWSYGILLWEIFSLGLNPYP 281 Query: 225 G 225 G Sbjct: 282 G 282 >4Y93-A nrPDB Length = 446 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 50/207 (24%), Positives = 101/207 (48%), Gaps = 19/207 (9%) Query: 18 WEV-PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLK 76 WE+ P+ L L+ +G+G +G V R + VA+K + + + E +++ Sbjct: 183 WEIDPKDLTFLKELGTGQFGVVKYG-KWRGQYDVAIKMIK---EGSMSEDEFIEEAKVMM 238 Query: 77 HLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQ-ALSDEHVQFLVYQ 133 +L HE ++ L V T I +++T M G LN + + + + + + Sbjct: 239 NLSHEKLVQLYGVCTKQRPI------FIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD 292 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRW---YR 189 + ++Y+ S +HRDL N VN+ +++ DFG+ R D+E T +++ + Sbjct: 293 VCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWA 352 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAEL 216 +PE+++ + ++ DIW+ G +M E+ Sbjct: 353 SPEVLM-YSKFSSKSDIWAFGVLMWEI 378 >5U6B-A nrPDB Length = 307 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 61/234 (26%), Positives = 106/234 (45%), Gaps = 31/234 (13%) Query: 28 RPVGSGAYGSVCSAYDARLRQ-----KVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 + +G G +G+V + +L Q KVAVK + + E +K H N Sbjct: 29 KTLGEGEFGAV---MEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPN 85 Query: 83 VIGLLDVFTPATSIEDF-SEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLR----- 136 V+ L+ V + E F + V ++ + DL++ + L D+ V L++ Sbjct: 86 VMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADI 145 Query: 137 --GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ---ADEEMTGYVA---TRWY 188 G++Y+ + IHRDL N +NE+ + + DFGL+++ D G +A +W Sbjct: 146 ASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWI 205 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAEL-LQGKALFPGS------DYIDQLKRI 235 A E + + + Y D+WS G M E+ +G+ +PG DY+ Q R+ Sbjct: 206 -AIESLADRV-YTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRL 257 >2VWV-A nrPDB Length = 302 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 54/208 (25%), Positives = 93/208 (44%), Gaps = 34/208 (16%) Query: 30 VGSGAYGSVCSA---YDARLRQKVAVKKLSRPFQSLIHARRTY-RELRLLKHLKHENVIG 85 +G+G +G VC + VA+K L + RR + E ++ +H N+I Sbjct: 24 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTE--RQRREFLSEASIMGQFEHPNIIR 81 Query: 86 LLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLL-------RGL 138 L V T + + + L + L++ ++ L+D QF V QL+ G+ Sbjct: 82 LEGVVTNSMPV-----MILTEFMENGALDSFLR---LNDG--QFTVIQLVGMLRGIASGM 131 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE---------MTGYVATRWYR 189 +Y+ +HRDL N+ VN + ++ DFGL+R +E + G + RW Sbjct: 132 RYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWT- 190 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELL 217 APE + + + D WS G +M E++ Sbjct: 191 APE-AIAFRKFTSASDAWSYGIVMWEVM 217 >5AMN-A nrPDB Length = 299 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 62/228 (27%), Positives = 106/228 (46%), Gaps = 24/228 (10%) Query: 18 WEVPQRLQGL-RPVGSGAYGSVCSAYDARLRQK-----VAVKKLSRPFQSLIHARRTYRE 71 WE P++ L + +G G +G V A L+ + VAVK L + S R E Sbjct: 18 WEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML-KENASPSELRDLLSE 76 Query: 72 LRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-------QALSD 124 +LK + H +VI L + + E +L G L K +AL+ Sbjct: 77 FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGF-LRESRKVGPGYPDERALTM 135 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT---- 180 + +Q+ +G++Y+ ++HRDL N+ V E +++I DFGL+R EE + Sbjct: 136 GDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR 195 Query: 181 --GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPG 225 G + +W A E + + ++ Q+ D+WS G ++ E++ G +PG Sbjct: 196 SQGRIPVKWM-AIESLFDHIYTTQS-DVWSFGVLLWEIVTLGGNPYPG 241 >5X02-A nrPDB Length = 347 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 65/248 (26%), Positives = 108/248 (43%), Gaps = 50/248 (20%) Query: 18 WEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQ-----KVAVKKLSRPFQSLIHARRTYRE 71 WE P + L+ + +GSGA+G V +A + + +VAVK L S E Sbjct: 43 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADS-SEREALMSE 101 Query: 72 LRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKC--QALSDEHV 127 L+++ L HEN++ LL T + I YL+ DL N ++ + S++ + Sbjct: 102 LKMMTQLGSHENIVNLLGACTLSGPI------YLIFEYCCYGDLLNYLRSKREKFSEDEI 155 Query: 128 QF----------------------LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELR 165 ++ YQ+ +G++++ +HRDL NV V ++ Sbjct: 156 EYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVK 215 Query: 166 ILDFGLARQADEEMTGYVA-------TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ 218 I DFGLAR + + YV +W APE + + Y D+WS G ++ E+ Sbjct: 216 ICDFGLARDIMSD-SNYVVRGNARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFS 272 Query: 219 -GKALFPG 225 G +PG Sbjct: 273 LGVNPYPG 280 >2OZA-A nrPDB Length = 356 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 54/199 (27%), Positives = 101/199 (50%), Gaps = 18/199 (9%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRL-LKHLKHENVIGLLD 88 +G G G V ++ R ++K A+K L Q ARR E+ L + + +++ ++D Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKML----QDCPKARR---EVELHWRASQCPHIVRIVD 78 Query: 89 VFTPATSIEDFSEVYLVTTLMGADLNNIVKC---QALSDEHVQFLVYQLLRGLKYIHSAG 145 V+ + + ++ L G +L + ++ QA ++ ++ + ++Y+HS Sbjct: 79 VYENLYAGRK-CLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 137 Query: 146 IIHRDLKPSNVAVNE---DCELRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWMHY 200 I HRD+KP N+ + L++ DFG A++ + +T T +Y APE+ L Y Sbjct: 138 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV-LGPEKY 196 Query: 201 NQTVDIWSVGCIMAELLQG 219 +++ D+WS+G IM LL G Sbjct: 197 DKSCDMWSLGVIMYILLCG 215 >1NY3-A nrPDB Length = 400 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 54/199 (27%), Positives = 101/199 (50%), Gaps = 18/199 (9%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRL-LKHLKHENVIGLLD 88 +G G G V ++ R ++K A+K L Q ARR E+ L + + +++ ++D Sbjct: 70 LGLGINGKVLQIFNKRTQEKFALKML----QDCPKARR---EVELHWRASQCPHIVRIVD 122 Query: 89 VFTPATSIEDFSEVYLVTTLMGADLNNIVKC---QALSDEHVQFLVYQLLRGLKYIHSAG 145 V+ + + ++ L G +L + ++ QA ++ ++ + ++Y+HS Sbjct: 123 VYENLYAGRK-CLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 181 Query: 146 IIHRDLKPSNVAVNE---DCELRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWMHY 200 I HRD+KP N+ + L++ DFG A++ + +T T +Y APE+ L Y Sbjct: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV-LGPEKY 240 Query: 201 NQTVDIWSVGCIMAELLQG 219 +++ D+WS+G IM LL G Sbjct: 241 DKSCDMWSLGVIMYILLCG 259 >3SOC-A nrPDB Length = 322 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 99/213 (46%), Gaps = 27/213 (12%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 LQ L G +G V A L + VAVK P Q + Y E+ L +KHEN+ Sbjct: 26 LQLLEVKARGRFGCVWKA--QLLNEYVAVKIF--PIQDKQSWQNEY-EVYSLPGMKHENI 80 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 + + TS++ +++L+T L++ +K +S + + + RGL Y+H Sbjct: 81 LQFIGAEKRGTSVD--VDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLH 138 Query: 143 ----------SAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE-----EMTGYVATRW 187 I HRD+K NV + + I DFGLA + + + G V TR Sbjct: 139 EDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRR 198 Query: 188 YRAPEIMLNWMHYNQT----VDIWSVGCIMAEL 216 Y APE++ +++ + +D++++G ++ EL Sbjct: 199 YMAPEVLEGAINFQRDAFLRIDMYAMGLVLWEL 231 >4YFF-A nrPDB Length = 311 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 58/205 (28%), Positives = 95/205 (46%), Gaps = 19/205 (9%) Query: 30 VGSGAYGSVCSAYDARLRQK-VAVKKL-SRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 +GSG++G V Y R R K VA+K+ + + S RE+ +L L H VI + Sbjct: 50 IGSGSFGKV---YKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFV 106 Query: 88 DVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA--LSDEHVQFLVYQLLRGLKYIHSA 144 + D S+ +VT + G L +++ Q L + + + +G++Y+H+ Sbjct: 107 -----GACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNL 161 Query: 145 G--IIHRDLKPSNVAVNEDCELRILDFGLAR---QADEE-MTGYVATRWYRAPEIMLNWM 198 IIHRDL N+ + ED + DFG +R DE+ MT + APE+ Sbjct: 162 TQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCT 221 Query: 199 HYNQTVDIWSVGCIMAELLQGKALF 223 Y D++S + E+L G+ F Sbjct: 222 RYTIKADVFSYALCLWEILTGEIPF 246 >3KA0-A nrPDB Length = 320 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 54/199 (27%), Positives = 101/199 (50%), Gaps = 18/199 (9%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRL-LKHLKHENVIGLLD 88 +G G G V ++ R ++K A+K L Q ARR E+ L + + +++ ++D Sbjct: 24 LGLGINGKVLQIFNKRTQEKFALKML----QDCPKARR---EVELHWRASQCPHIVRIVD 76 Query: 89 VFTPATSIEDFSEVYLVTTLMGADLNNIVKC---QALSDEHVQFLVYQLLRGLKYIHSAG 145 V+ + + ++ L G +L + ++ QA ++ ++ + ++Y+HS Sbjct: 77 VYENLYAGRK-CLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 135 Query: 146 IIHRDLKPSNVAVNE---DCELRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWMHY 200 I HRD+KP N+ + L++ DFG A++ + +T T +Y APE+ L Y Sbjct: 136 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEV-LGPEKY 194 Query: 201 NQTVDIWSVGCIMAELLQG 219 +++ D+WS+G IM LL G Sbjct: 195 DKSCDMWSLGVIMYILLCG 213 >4CRS-A nrPDB Length = 341 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 50/205 (24%), Positives = 94/205 (45%), Gaps = 19/205 (9%) Query: 33 GAYGSVCSAYDARLRQKVAVKKLSR-------PFQSLIHARRTYRELRLLKHLKHENVIG 85 G +G V A + A+K L + SL+ +R + + ++H ++ Sbjct: 23 GHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFE---TVNSVRHPFLVN 79 Query: 86 LLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAG 145 L F + +++ G DL + S+ F ++ GL+Y+H Sbjct: 80 LFACFQTKEHV-----CFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHK 134 Query: 146 IIHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYRAPEIMLNWMHYNQ 202 I++RDLK N+ ++ + ++I DFGL ++ + + + T + APE+ L Y + Sbjct: 135 IVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV-LTETSYTR 193 Query: 203 TVDIWSVGCIMAELLQGKALFPGSD 227 VD W +G ++ E+L G++ FPG D Sbjct: 194 AVDWWGLGVLIYEMLVGESPFPGDD 218 >4XUF-A nrPDB Length = 297 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 66/249 (26%), Positives = 104/249 (41%), Gaps = 52/249 (20%) Query: 18 WEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQ-----KVAVKKLSRPFQSLIHARRTYRE 71 WE P + L+ + +GSGA+G V +A + + +VAVK L S E Sbjct: 4 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADS-SEREALMSE 62 Query: 72 LRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQ--------- 120 L+++ L HEN++ LL T + I YL+ DL N ++ + Sbjct: 63 LKMMTQLGSHENIVNLLGACTLSGPI------YLIFEYCCYGDLLNYLRSKREKFSEDEI 116 Query: 121 ---------------ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELR 165 L+ E + YQ+ +G++++ +HRDL NV V ++ Sbjct: 117 EYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVK 176 Query: 166 ILDFGLARQADEEMTGYVATRWYRAPEIMLNWMH--------YNQTVDIWSVGCIMAELL 217 I DFGLAR + + YV R P + WM Y D+WS G ++ E+ Sbjct: 177 ICDFGLARDIMSD-SNYVVRGNARLP---VKWMAPESLFEGIYTIKSDVWSYGILLWEIF 232 Query: 218 Q-GKALFPG 225 G +PG Sbjct: 233 SLGVNPYPG 241 >2Y6O-A nrPDB Length = 291 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 88/206 (42%), Gaps = 32/206 (15%) Query: 30 VGSGAYGSVCSA---YDARLRQKVAVKKLSRPFQSLIHARRTY-RELRLLKHLKHENVIG 85 +G G +G VCS + VA+K L + RR + E ++ H N+I Sbjct: 22 IGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTD--KQRRDFLSEASIMGQFDHPNIIH 79 Query: 86 LLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLL-------RGL 138 L V T + +E Y+ + A L +F V QL+ G+ Sbjct: 80 LEGVVTKCKPVMIITE-YMENGSLDA---------FLRKNDGRFTVIQLVGMLRGIGSGM 129 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE-------MTGYVATRWYRAP 191 KY+ +HRDL N+ VN + ++ DFG++R +++ G + RW AP Sbjct: 130 KYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRW-TAP 188 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELL 217 E + + + D+WS G +M E++ Sbjct: 189 E-AIAYRKFTSASDVWSYGIVMWEVM 213 >5E8V-A nrPDB Length = 316 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 60/217 (27%), Positives = 103/217 (47%), Gaps = 39/217 (17%) Query: 30 VGSGAYGSVCSAYDARLRQK-------VAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 VG G + V Y A+L+Q VAVK P++ + +T +++ +LKHEN Sbjct: 17 VGKGRFAEV---YKAKLKQNTSEQFETVAVKIF--PYEEYA-SWKTEKDIFSDINLKHEN 70 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDEHVQFLVYQLLRGLKYI 141 ++ L T + + +L+T +L + +S E ++ L L RG+ ++ Sbjct: 71 ILQFLTAEERKTELG--KQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHL 128 Query: 142 HSAG---------IIHRDLKPSNVAVNEDCELRILDFGLARQADEEM-------TGYVAT 185 HS I+HRDLK SN+ V D + DFGL+ + D + +G V T Sbjct: 129 HSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGT 188 Query: 186 RWYRAPEIMLNWMH------YNQTVDIWSVGCIMAEL 216 Y APE++ + M+ + QT D++S+ ++ E+ Sbjct: 189 ARYMAPEVLASAMNLENVESFKQT-DVYSMALVLWEM 224 >5O2C-A nrPDB Length = 380 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 57/237 (24%), Positives = 110/237 (46%), Gaps = 12/237 (5%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G GA+ +V D +VA +L + +R E +LK L+H N++ D Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 92 Query: 90 FTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAG-- 145 + + ++ + LVT LM G + + + + + ++ Q+L+GL+++H+ Sbjct: 93 W--ESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 150 Query: 146 IIHRDLKPSNVAVNE-DCELRILDFGLARQADEEMT-GYVATRWYRAPEIMLNWMHYNQT 203 IIHRDLK N+ + ++I D GLA + T + APE+ HY+++ Sbjct: 151 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEE--HYDES 208 Query: 204 VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQ 260 VD+++ G M E+ + +P S+ + + +V P K++ + I+ Sbjct: 209 VDVYAFGMCMLEMATSE--YPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIE 263 >3VHK-A nrPDB Length = 368 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 74/299 (24%), Positives = 124/299 (41%), Gaps = 82/299 (27%) Query: 14 NKTVWEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQK------VAVKKLSRPFQSLIHAR 66 + + WE P+ RL+ +P+G GA+G V A DA K VAVK L H R Sbjct: 20 DASKWEFPRDRLKLGKPLGRGAFGQVIEA-DAFGIDKTATCRTVAVKMLKEGATHSEH-R 77 Query: 67 RTYRELRLLKHLKHE-NVIGLLDVFT----PATSIEDFSEVYLVTTLMGADLN------- 114 EL++L H+ H NV+ LL T P I +F + ++T + + N Sbjct: 78 ALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKT 137 Query: 115 -----------------------------------NIVKCQALSD--------------- 124 V+ ++LSD Sbjct: 138 KGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFL 197 Query: 125 --EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE---- 178 EH+ +Q+ +G++++ S IHRDL N+ ++E ++I DFGLAR ++ Sbjct: 198 TLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYV 257 Query: 179 --MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKR 234 + +W APE + + ++ Q+ D+WS G ++ E+ G + +PG ++ R Sbjct: 258 RKGDARLPLKWM-APETIFDRVYTIQS-DVWSFGVLLWEIFSLGASPYPGVKIDEEFCR 314 >1FVR-A nrPDB Length = 327 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 87/206 (42%), Gaps = 21/206 (10%) Query: 30 VGSGAYGSVCSAYDAR--LRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE-NVIGL 86 +G G +G V A + LR A+K++ + + S R EL +L L H N+I L Sbjct: 33 IGEGNFGQVLKARIKKDGLRMDAAIKRM-KEYASKDDHRDFAGELEVLCKLGHHPNIINL 91 Query: 87 LDV------------FTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQL 134 L + P ++ DF V A LS + + + Sbjct: 92 LGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADV 151 Query: 135 LRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD---EEMTGYVATRWYRAP 191 RG+ Y+ IHRDL N+ V E+ +I DFGL+R + ++ G + RW Sbjct: 152 ARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIE 211 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELL 217 LN+ Y D+WS G ++ E++ Sbjct: 212 S--LNYSVYTTNSDVWSYGVLLWEIV 235 >5O2B-A nrPDB Length = 285 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/238 (23%), Positives = 110/238 (46%), Gaps = 12/238 (5%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G GA+ +V D +VA +L + +R E +LK L+H N++ D Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 83 Query: 90 FTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAG-- 145 + + ++ + LVT LM G + + + + + ++ Q+L+GL+++H+ Sbjct: 84 W--ESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 141 Query: 146 IIHRDLKPSNVAVNE-DCELRILDFGLARQADEEMT-GYVATRWYRAPEIMLNWMHYNQT 203 IIHRDLK N+ + ++I D GLA + T + APE+ HY+++ Sbjct: 142 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEE--HYDES 199 Query: 204 VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQS 261 VD+++ G M E+ + +P S+ + + +V P K++ + I+ Sbjct: 200 VDVYAFGMCMLEMATSE--YPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEG 255 >4BTK-A nrPDB Length = 337 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 62/221 (28%), Positives = 99/221 (44%), Gaps = 34/221 (15%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLS--RPFQSLIHARRTYRELRLLKH 77 V R + L+ +G G +G + A D R+ VA+K S +P Q L E+ +LK Sbjct: 54 VKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVL------KMEVAVLKK 107 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ---ALSDEHVQFLVYQL 134 L+ ++ + F E F+ Y+V L G +L ++ + Q + L Q+ Sbjct: 108 LQGKDHVCR---FIGCGRNEKFN--YVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQI 162 Query: 135 LRGLKYIHSAGIIHRDLKPSNVAVN------EDCELRILDFGLARQADE---------EM 179 L ++ IHS G +HRD+KPSN A+ C + LDFGLARQ + Sbjct: 163 LESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYM--LDFGLARQYTNTTGDVRPPRNV 220 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGK 220 G+ T Y + N + D+WS+ ++ E G+ Sbjct: 221 AGFRGTVRYASVNAHKN-REMGRHDDLWSLFYMLVEFAVGQ 260 >4X7Q-B nrPDB Length = 312 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 60/222 (27%), Positives = 105/222 (47%), Gaps = 19/222 (8%) Query: 14 NKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR----PFQSLIHARRTY 69 ++ +E RL L +G G +G+V + + R +VA+K + R + L + Sbjct: 25 DREAFEAEYRLGPL--LGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCP 82 Query: 70 RELRLLKHLK----HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADL-NNIVKCQALSD 124 E+ LL + H VI LLD F + E F V L L DL + I + L + Sbjct: 83 LEVALLWKVGAGGGHPGVIRLLDWFE---TQEGFMLV-LERPLPAQDLFDYITEKGPLGE 138 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN--EDCELRILDFGL-ARQADEEMTG 181 + Q++ +++ HS G++HRD+K N+ ++ C +++DFG A DE T Sbjct: 139 GPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCA-KLIDFGSGALLHDEPYTD 197 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALF 223 + TR Y PE + ++ +WS+G ++ +++ G F Sbjct: 198 FDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPF 239 >4NFN-A nrPDB Length = 309 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 62/221 (28%), Positives = 99/221 (44%), Gaps = 34/221 (15%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLS--RPFQSLIHARRTYRELRLLKH 77 V R + L+ +G G +G + A D R+ VA+K S +P Q L E+ +LK Sbjct: 19 VKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVL------KMEVAVLKK 72 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ---ALSDEHVQFLVYQL 134 L+ ++ + F E F+ Y+V L G +L ++ + Q + L Q+ Sbjct: 73 LQGKDHVCR---FIGCGRNEKFN--YVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQI 127 Query: 135 LRGLKYIHSAGIIHRDLKPSNVAVN------EDCELRILDFGLARQADE---------EM 179 L ++ IHS G +HRD+KPSN A+ C + LDFGLARQ + Sbjct: 128 LESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYM--LDFGLARQYTNTTGDVRPPRNV 185 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGK 220 G+ T Y + N + D+WS+ ++ E G+ Sbjct: 186 AGFRGTVRYASVNAHKN-REMGRHDDLWSLFYMLVEFAVGQ 225 >3KUL-B nrPDB Length = 325 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 93/210 (44%), Gaps = 40/210 (19%) Query: 30 VGSGAYGSVCSAYDARLR---QK---VAVKKLSRPFQSLIHARRTY-RELRLLKHLKHEN 82 +GSG G VC RLR Q+ VA+K L + RR + E ++ H N Sbjct: 57 IGSGDSGEVCYG---RLRVPGQRDVPVAIKALKAGYTE--RQRRDFLSEASIMGQFDHPN 111 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLL------ 135 +I L V T +VT M L+ ++ QF + QL+ Sbjct: 112 IIRLEGVVTRGRL------AMIVTEYMENGSLDTFLRTH-----DGQFTIMQLVGMLRGV 160 Query: 136 -RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE-------MTGYVATRW 187 G++Y+ G +HRDL NV V+ + ++ DFGL+R +++ G + RW Sbjct: 161 GAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRW 220 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 APE + + ++ D+WS G +M E+L Sbjct: 221 -TAPE-AIAFRTFSSASDVWSFGVVMWEVL 248 >2BUJ-A nrPDB Length = 317 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 35/118 (29%), Positives = 64/118 (54%), Gaps = 14/118 (11%) Query: 118 KCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE 177 K L+++ + +L+ + RGL+ IH+ G HRDLKP+N+ + ++ + ++D G QA Sbjct: 127 KGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACI 186 Query: 178 EMTG---------YVATRW---YRAPEIMLNWMH--YNQTVDIWSVGCIMAELLQGKA 221 + G + A R YRAPE+ H ++ D+WS+GC++ ++ G+ Sbjct: 187 HVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEG 244 >3SXS-A nrPDB Length = 268 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 51/198 (25%), Positives = 90/198 (45%), Gaps = 18/198 (9%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 L+ +GSG +G V + + VAVK + S ++E + + L H ++ Sbjct: 13 LKELGSGQFG-VVKLGKWKGQYDVAVKMIKEGSMS---EDEFFQEAQTMMKLSHPKLVKF 68 Query: 87 LDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFL--VYQLLRGLKYIHS 143 V + I Y+VT + L N ++ E Q L Y + G+ ++ S Sbjct: 69 YGVCSKEYPI------YIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLES 122 Query: 144 AGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRW---YRAPEIMLNWMH 199 IHRDL N V+ D +++ DFG+ R D++ V T++ + APE+ ++ Sbjct: 123 HQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEV-FHYFK 181 Query: 200 YNQTVDIWSVGCIMAELL 217 Y+ D+W+ G +M E+ Sbjct: 182 YSSKSDVWAFGILMWEVF 199 >4IDT-A nrPDB Length = 356 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 65/221 (29%), Positives = 102/221 (46%), Gaps = 31/221 (14%) Query: 9 YRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT 68 YR+E++ W Q LR +G G++G V D + + AVKK+ + R Sbjct: 69 YREEVH---WATHQ----LR-LGRGSFGEVHRMEDKQTGFQCAVKKVR------LEVFRA 114 Query: 69 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-LSDEHV 127 EL L ++ L + F E+ L G L +VK Q L ++ Sbjct: 115 -EELMACAGLTSPRIVPLYGAVREGPWVNIFMEL-----LEGGSLGQLVKEQGCLPEDRA 168 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED-CELRILDFG--LARQAD----EEMT 180 + + Q L GL+Y+HS I+H D+K NV ++ D + DFG + Q D + +T Sbjct: 169 LYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLT 228 Query: 181 G-YV-ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQG 219 G Y+ T + APE++L + VD+WS C+M +L G Sbjct: 229 GDYIPGTETHMAPEVVLG-RSCDAKVDVWSSCCMMLHMLNG 268 >3MDY-A nrPDB Length = 337 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 57/221 (25%), Positives = 103/221 (46%), Gaps = 34/221 (15%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLR-QKVAVKKLSRPFQSLIHARRTYRELRLLKH- 77 + +++Q ++ +G G YG V + + R +KVAVK ++ +RE + + Sbjct: 35 IAKQIQMVKQIGKGRYGEV---WMGKWRGEKVAVKVFFTTEEA-----SWFRETEIYQTV 86 Query: 78 -LKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLL 135 ++HEN++G + T ++++YL+T L + +K L + + L Y + Sbjct: 87 LMRHENILGFIAADIKGTG--SWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSV 144 Query: 136 RGLKYIHSA--------GIIHRDLKPSNVAVNEDCELRILDFGLA-------RQADEEMT 180 GL ++H+ I HRDLK N+ V ++ I D GLA + D Sbjct: 145 SGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPN 204 Query: 181 GYVATRWYRAPEIM---LNWMHYNQTV--DIWSVGCIMAEL 216 V T+ Y PE++ LN H+ + D++S G I+ E+ Sbjct: 205 TRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEV 245 >4PDO-A nrPDB Length = 299 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 54/214 (25%), Positives = 96/214 (44%), Gaps = 43/214 (20%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR-------ELRLLKHLKH 80 + +G+G +G V Y L+ K++ ++L A T + E ++ H Sbjct: 40 KVIGAGEFGEV---YKGMLKTSSGKKEVPVAIKTL-KAGYTEKQRVDFLGEAGIMGQFSH 95 Query: 81 ENVI---GLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLL-- 135 N+I G++ + P I ++ E N + L ++ +F V QL+ Sbjct: 96 HNIIRLEGVISKYKPMMIITEYME-------------NGALDKFLREKDGEFSVLQLVGM 142 Query: 136 -----RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR--QADEEMT-----GYV 183 G+KY+ + +HRDL N+ VN + ++ DFGL+R + D E T G + Sbjct: 143 LRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKI 202 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 RW APE +++ + D+WS G +M E++ Sbjct: 203 PIRW-TAPE-AISYRKFTSASDVWSFGIVMWEVM 234 >3FXW-A nrPDB Length = 336 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 60/243 (24%), Positives = 111/243 (45%), Gaps = 50/243 (20%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE-------N 82 +G G G V + R QK A+K L Y + + + H + Sbjct: 37 LGLGVNGKVLECFHRRTGQKCALKLL-------------YDSPKARQEVDHHWQASGGPH 83 Query: 83 VIGLLDVFTPATSIEDFSEVYLVT--TLMGADLNNIVK---CQALSDEHVQFLVYQLLRG 137 ++ +LDV+ ++ L+ + G +L + ++ QA ++ ++ + Sbjct: 84 IVCILDVYE---NMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTA 140 Query: 138 LKYIHSAGIIHRDLKPSNV---AVNEDCELRILDFGLARQADEE-MTGYVATRWYRAPEI 193 ++++HS I HRD+KP N+ + +D L++ DFG A++ + + T +Y APE+ Sbjct: 141 IQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEV 200 Query: 194 MLNWMHYNQTVDIWSVGCIMAELL---------QGKALFPGSDYIDQLKRIMEV--VGTP 242 L Y+++ D+WS+G IM LL G+A+ PG +KR + + G P Sbjct: 201 -LGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPG------MKRRIRLGQYGFP 253 Query: 243 SPE 245 +PE Sbjct: 254 NPE 256 >3QGY-A nrPDB Length = 286 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 52/210 (24%), Positives = 97/210 (46%), Gaps = 23/210 (10%) Query: 21 PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKH 80 P L ++ +GSG +G V Y + KVA+K + + + E ++ L H Sbjct: 26 PSELTFVQEIGSGQFGLVHLGYWLN-KDKVAIKTIK---EGSMSEDDFIEEAEVMMKLSH 81 Query: 81 ENVIGLLDVF---TPATSIEDFSEVYLVTTLMGADLNNIVKCQ--ALSDEHVQFLVYQLL 135 ++ L V P + +F E L++ ++ Q + E + + + Sbjct: 82 PKLVQLYGVCLEQAPICLVFEFME--------HGCLSDYLRTQRGLFAAETLLGMCLDVC 133 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRW---YRAP 191 G+ Y+ A +IHRDL N V E+ +++ DFG+ R D++ T T++ + +P Sbjct: 134 EGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASP 193 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELL-QGK 220 E+ ++ Y+ D+WS G +M E+ +GK Sbjct: 194 EV-FSFSRYSSKSDVWSFGVLMWEVFSEGK 222 >3TKU-A nrPDB Length = 433 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 57/223 (25%), Positives = 107/223 (47%), Gaps = 20/223 (8%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR-TYRELR-LLKHLKHENVI 84 ++ +G GA+G V + + +++ K+ ++ L A +RE R +L + + + Sbjct: 95 IKVIGRGAFGEV-AVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWIT 153 Query: 85 GLLDVFTPATSIEDFSEVYLVTTL-MGADLNNIVKC--QALSDEHVQFLVYQLLRGLKYI 141 L F +D + +YLV +G DL ++ L ++ +F + +++ + I Sbjct: 154 ALHYAF------QDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSI 207 Query: 142 HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY----VATRWYRAPEI---M 194 H +HRD+KP NV ++ + +R+ DFG + +++ T V T Y +PEI M Sbjct: 208 HQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAM 267 Query: 195 LNWM-HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 + M Y D WS+G M E+L G+ F ++ +IM Sbjct: 268 EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIM 310 >5HLW-A nrPDB Length = 299 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 60/246 (24%), Positives = 108/246 (43%), Gaps = 37/246 (15%) Query: 30 VGSGAYGSVCSAYDARL------RQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 +G G +G V Y L + AVK L+R + + E ++K H NV Sbjct: 28 IGRGHFGCV---YHGTLLDNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDFSHPNV 83 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVY--QLLRGLKYI 141 + LL + + S + ++ + DL N ++ + + + + Q+ +G+KY+ Sbjct: 84 LSLLGICLRSEG----SPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYL 139 Query: 142 HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRWYRAPEIMLNWM-- 198 S +HRDL N ++E +++ DFGLAR D+E Y + ++ + WM Sbjct: 140 ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKE---YYSVHNKTGAKLPVKWMAL 196 Query: 199 ------HYNQTVDIWSVGCIMAELLQGKA-------LFPGSDYIDQLKRIMEVVGTPSP- 244 + D+WS G ++ EL+ A F + Y+ Q +R+++ P P Sbjct: 197 ESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPL 256 Query: 245 -EVLAK 249 EV+ K Sbjct: 257 YEVMLK 262 >6FER-A nrPDB Length = 309 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 58/234 (24%), Positives = 97/234 (41%), Gaps = 44/234 (18%) Query: 17 VWEVPQRLQGLR-PVGSGAYGSV--CS------------AYDARLRQKV--AVKKLSRPF 59 V E P++L + +G G +G V C A D Q V AVK L Sbjct: 3 VEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADA 62 Query: 60 QSLIHARRTY-RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK 118 +AR + +E++++ LK N+I LL A I D + + DLN + Sbjct: 63 NK--NARNDFLKEIKIMSRLKDPNIIHLL-----AVCITDDPLCMITEYMENGDLNQFLS 115 Query: 119 -----------CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRIL 167 + +S +++F+ Q+ G+KY+ S +HRDL N V ++ ++I Sbjct: 116 RHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIA 175 Query: 168 DFGLARQADE------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAE 215 DFG++R + + RW I+L + D+W+ G + E Sbjct: 176 DFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLG--KFTTASDVWAFGVTLWE 227 >4M66-A nrPDB Length = 325 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 58/232 (25%), Positives = 112/232 (48%), Gaps = 27/232 (11%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + L+ L VG G +G V A+ VAVK ++++++ E++ + +L++E Sbjct: 20 EELKKLEFVGKGGFGVVFRAHHRTWNHDVAVK--------IVNSKKISWEVKAMVNLRNE 71 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQF-LVYQLLRGLK 139 NV+ LL V T + S LVT M L +++ +A + L+ +++ G+ Sbjct: 72 NVLLLLGV-TEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMC 130 Query: 140 YIHSAG--IIHRDLKPSNVAVNEDCELRILDFGLAR---------QADEEMTGYVATRWY 188 Y+HS ++HRDLKPSN+ ++ + ++ DFGL+ + T Y Sbjct: 131 YLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAY 190 Query: 189 RAPEIMLNW-MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVV 239 PE++ + ++ D++S G ++ +L G+ ++ +D+ I E V Sbjct: 191 LDPELLFKVNLKASKASDVYSFGILVWAVLAGRE----AELVDKTSLIRETV 238 >6DBM-A nrPDB Length = 318 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 58/206 (28%), Positives = 92/206 (44%), Gaps = 19/206 (9%) Query: 24 LQGLRPVGSGAYGSVC-SAYDAR---LRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 L+ +R +G G +G V YD + VAVK L + H +E+ +L+ L Sbjct: 33 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-KADAGPQHRSGWKQEIDILRTLY 91 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDEHVQFLVYQLLRGL 138 HE++I A + + + LV + L + + ++ + Q+ G+ Sbjct: 92 HEHIIKYKGCCEDAGA----ASLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGM 147 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATR-------WYRAP 191 Y+HS IHRDL NV ++ D ++I DFGLA+ E Y WY AP Sbjct: 148 AYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-AP 206 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELL 217 E + + Y + D+WS G + ELL Sbjct: 207 ECLKEYKFYYAS-DVWSFGVTLYELL 231 >5LPZ-A nrPDB Length = 332 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 65/233 (27%), Positives = 97/233 (41%), Gaps = 58/233 (24%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA-----RRTYRELRLLKHLKHENVI 84 +GSG +G V Y A L+ AV + LIH R E+ + +KH N++ Sbjct: 25 IGSGGFGDV---YKAILKDGSAV-----AIKKLIHVSGQGDREFMAEMETIGKIKHRNLV 76 Query: 85 GLLDV------------FTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVY 132 LL F S+ED V G LN + + + Sbjct: 77 PLLGYCKVGDERLLVYEFMKYGSLED---VLHDPKKAGVKLNWSTRRK---------IAI 124 Query: 133 QLLRGLKYIH---SAGIIHRDLKPSNVAVNEDCELRILDFGLAR---QADEEMT------ 180 RGL ++H S IIHRD+K SNV ++E+ E R+ DFG+AR D ++ Sbjct: 125 GSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAG 184 Query: 181 --GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQ 231 GYV +Y++ + D++S G ++ ELL GK D+ D Sbjct: 185 TPGYVPPEYYQS-------FRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDN 230 >4TPT-A nrPDB Length = 303 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 52/214 (24%), Positives = 93/214 (43%), Gaps = 36/214 (16%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTY-RELRLLKHLKHENVIGLLD 88 +G G +G + + +K+L R + ++T+ E+++++ L H NV+ + Sbjct: 8 LGKGFFGQAIKVTHKATGKVMVMKELIRCDE---ETQKTFLTEVKVMRSLDHPNVLKFIG 64 Query: 89 VFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALS--DEHVQFLVYQLLRGLKYIHSAGI 146 V + +E + G L + ++ + V+F + G+ Y+HS I Sbjct: 65 VLYKDKKLNLLTEY-----IEGGTLKDFLRSMDPFPWQQKVRF-AKGIASGMAYLHSMCI 118 Query: 147 IHRDLKPSNVAVNEDCELRILDFGLARQADEEMT-----------------------GYV 183 IHRDL N + D + + DFGL+R EE V Sbjct: 119 IHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVV 178 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 ++ APE MLN Y++TVDI+S G ++ E++ Sbjct: 179 GNPYWMAPE-MLNGKSYDETVDIFSFGIVLCEII 211 >3ALO-A nrPDB Length = 327 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 69/305 (22%), Positives = 127/305 (41%), Gaps = 45/305 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + L+ L +G GAYGSV Q +AVK++ +S + + + L L + Sbjct: 22 EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRI----RSTVDEKEQKQLLMDLDVVMRS 77 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC------QALSDEHVQFLVYQLL 135 + + F A E + ++ LM + K + +E + + + Sbjct: 78 SDCPYIVQFYGALFRE--GDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATV 135 Query: 136 RGLKYI-HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM--TGYVATRWYRAPE 192 + L ++ + IIHRD+KPSN+ ++ +++ DFG++ Q + + T R Y APE Sbjct: 136 KALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPE 195 Query: 193 IM---LNWMHYNQTVDIWSVGCIMAELLQGKALFPG-SDYIDQLKRIMEVVGTPSPEVLA 248 + + Y+ D+WS+G + EL G+ +P + DQL ++ V G P Sbjct: 196 RIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQV--VKGDP-----P 248 Query: 249 KISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 ++S+ R + +P I+ + L D +R E L H + Sbjct: 249 QLSNSEEREF-------------------SPSFINFVNLCLTKDESKRPKYKELLKHPFI 289 Query: 309 SQYHD 313 Y + Sbjct: 290 LMYEE 294 >6HV0-A nrPDB Length = 416 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 84/321 (26%), Positives = 136/321 (42%), Gaps = 68/321 (21%) Query: 30 VGSGAYGSVC--SAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL-KHENVIGL 86 +G GA G++ +D R VAVK++ S RE++LL+ +H NVI Sbjct: 16 LGHGAEGTIVYRGMFDNR---DVAVKRILPECFSFAD-----REVQLLRESDEHPNVIRY 67 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQ--FLVYQLLRGLKYIHSA 144 + +D Y+ L A L V+ + + ++ L+ Q GL ++HS Sbjct: 68 F------CTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSL 121 Query: 145 GIIHRDLKPSNVAV---NEDCELR--ILDFGLA------RQADEEMTGYVATRWYRAPEI 193 I+HRDLKP N+ + N +++ I DFGL R + +G T + APE+ Sbjct: 122 NIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 181 Query: 194 MLNWMHYN--QTVDIWSVGCIMAELL-QGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI 250 + N TVDI+S GC+ ++ +G F S L+R + +L Sbjct: 182 LSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKS-----LQRQANI-------LLGAC 229 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF-- 308 S + L P +D+ +A +L+ +M+ +D +R SA L H +F Sbjct: 230 S-------LDCLHPEKHEDV---------IARELIEKMIAMDPQKRPSAKHVLKHPFFWS 273 Query: 309 -----SQYHDPEDEPEAEPYD 324 + D D E E D Sbjct: 274 LEKQLQFFQDVSDRIEKESLD 294 >4PWN-A nrPDB Length = 274 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 65/289 (22%), Positives = 123/289 (42%), Gaps = 41/289 (14%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G G++ +V D +VA +L + +R E +LK L+H N++ D Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDS 77 Query: 90 FTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAG-- 145 + ++++ + LVT LM G + + + + + ++ Q+L+GL+++H+ Sbjct: 78 W--ESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPP 135 Query: 146 IIHRDLKPSNVAVNE-DCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMH---YN 201 IIHRDLK N+ + ++I D GLA E A PE M M+ Y+ Sbjct: 136 IIHRDLKCDNIFITGPTGSVKIGDLGLATL---EKRASFAKSVIGTPEFMAPEMYEEKYD 192 Query: 202 QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQS 261 ++VD+++ G M E+ + +P S+ + + V P K+ Sbjct: 193 ESVDVYAFGMCMLEMATSE--YPYSECQNAAQIYRRVTSGVKPASFDKV----------- 239 Query: 262 LPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 A P +++ + + D+R S + L HA+F + Sbjct: 240 ---------------AIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >5LPV-A nrPDB Length = 296 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 65/233 (27%), Positives = 97/233 (41%), Gaps = 58/233 (24%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA-----RRTYRELRLLKHLKHENVI 84 +GSG +G V Y A L+ AV + LIH R E+ + +KH N++ Sbjct: 25 IGSGGFGDV---YKAILKDGSAV-----AIKKLIHVSGQGDREFMAEMETIGKIKHRNLV 76 Query: 85 GLLDV------------FTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVY 132 LL F S+ED V G LN + + + Sbjct: 77 PLLGYCKVGDERLLVYEFMKYGSLED---VLHDPKKAGVKLNWSTRRK---------IAI 124 Query: 133 QLLRGLKYIH---SAGIIHRDLKPSNVAVNEDCELRILDFGLAR---QADEEMT------ 180 RGL ++H S IIHRD+K SNV ++E+ E R+ DFG+AR D ++ Sbjct: 125 GSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAG 184 Query: 181 --GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQ 231 GYV +Y++ + D++S G ++ ELL GK D+ D Sbjct: 185 TPGYVPPEYYQS-------FRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDN 230 >4AT3-A nrPDB Length = 299 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 57/221 (25%), Positives = 93/221 (42%), Gaps = 46/221 (20%) Query: 28 RPVGSGAYGSV--------CSAYDARLRQKVAVKKLSRPFQSLIHARRTY-RELRLLKHL 78 R +G GA+G V C D L VAVK L + AR+ + RE LL +L Sbjct: 19 RELGEGAFGKVFLAECYNLCPEQDKIL---VAVKTLKDASDN---ARKDFHREAELLTNL 72 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA--------------LSD 124 +HE+++ V +E + + + DLN ++ L+ Sbjct: 73 QHEHIVKFYGV-----CVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQ 127 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY-- 182 + + Q+ G+ Y+ S +HRDL N V E+ ++I DFG++R D T Y Sbjct: 128 SQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSR--DVYSTDYYR 185 Query: 183 ------VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 + RW IM + + D+WS+G ++ E+ Sbjct: 186 VGGHTMLPIRWMPPESIM--YRKFTTESDVWSLGVVLWEIF 224 >4AW2-A nrPDB Length = 437 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 57/222 (25%), Positives = 100/222 (45%), Gaps = 18/222 (8%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR-TYRELRLLKHLKHENVIG 85 L+ +G GA+G V + + KV K+ ++ L A +RE R + I Sbjct: 79 LKVIGRGAFGEV-AVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKWIT 137 Query: 86 LLDVFTPATSIEDFSEVYLVTTL-MGADLNNIVKC--QALSDEHVQFLVYQLLRGLKYIH 142 L + +D + +YLV +G DL ++ L +E +F + +++ + +H Sbjct: 138 TLHY-----AFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVH 192 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY----VATRWYRAPEIML--- 195 +HRD+KP N+ ++ + +R+ DFG + E+ T V T Y +PEI+ Sbjct: 193 QLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAME 252 Query: 196 -NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 Y D WS+G M E+L G+ F ++ +IM Sbjct: 253 GGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIM 294 >4JLC-A nrPDB Length = 657 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 51/193 (26%), Positives = 86/193 (44%), Gaps = 22/193 (11%) Query: 70 RELRLLKHLKHENVIGLLDVFTPATS-----IEDFSEVYLVTTLMGADLNNIVKCQALSD 124 RE +LK L H+N++ L + T+ I +F + T++ N L + Sbjct: 55 REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSN----AYGLPE 110 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNV--AVNEDCE--LRILDFGLARQA--DEE 178 ++ ++ G+ ++ GI+HRD+KP N+ + ED + ++ DFG AR+ DE+ Sbjct: 111 SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 170 Query: 179 MTGYVATRWYRAPEI----MLNWMH---YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQ 231 T Y P++ +L H Y TVD+WSVG G F + + Sbjct: 171 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRR 230 Query: 232 LKRIMEVVGTPSP 244 K +M + T P Sbjct: 231 NKEVMYKIITGKP 243 >5FM2-A nrPDB Length = 355 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 62/242 (25%), Positives = 106/242 (43%), Gaps = 38/242 (15%) Query: 18 WEVPQRLQGL-RPVGSGAYGSVCSAYDARLRQK-----VAVKKLSRPFQSLIHARRTYRE 71 WE P++ L + +G G +G V A L+ + VAVK L + S R E Sbjct: 59 WEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML-KENASPSELRDLLSE 117 Query: 72 LRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC------------ 119 +LK + H +VI L + + E +L G L K Sbjct: 118 FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGF-LRESRKVGPGYLGSGGSRN 176 Query: 120 ---------QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFG 170 +AL+ + +Q+ +G++Y+ ++HRDL N+ V E +++I DFG Sbjct: 177 SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFG 236 Query: 171 LARQADEEMT------GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALF 223 L+R EE + G + +W A E + + ++ Q+ D+WS G ++ E++ G + Sbjct: 237 LSRDVYEEDSYVKRSQGRIPVKWM-AIESLFDHIYTTQS-DVWSFGVLLWEIVTLGGNPY 294 Query: 224 PG 225 PG Sbjct: 295 PG 296 >4OLI-A nrPDB Length = 645 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 92/209 (44%), Gaps = 25/209 (11%) Query: 24 LQGLRPVGSGAYGSVC-SAYDAR---LRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 L+ +R +G G +G V YD + VAVK L H +E+ +L+ L Sbjct: 355 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQ-HRSGWKQEIDILRTLY 413 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTL----MGADLNNIVKCQALSDEHVQFLVYQLL 135 HE++I ED E L + +G+ L + + ++ + Q+ Sbjct: 414 HEHIIKY------KGCCEDQGEKSLQLVMEYVPLGS-LRDYLPRHSIGLAQLLLFAQQIC 466 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATR-------WY 188 G+ Y+HS IHR+L NV ++ D ++I DFGLA+ E Y WY Sbjct: 467 EGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY 526 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 APE + + Y + D+WS G + ELL Sbjct: 527 -APECLKEYKFYYAS-DVWSFGVTLYELL 553 >4PL5-B nrPDB Length = 435 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 74/297 (24%), Positives = 125/297 (42%), Gaps = 59/297 (19%) Query: 30 VGSGAYGSVC--SAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL-KHENVIGL 86 +G GA G++ +D R VAVK++ S RE++LL+ +H NVI Sbjct: 35 LGHGAEGTIVYKGMFDNR---DVAVKRILPECFSFAD-----REVQLLRESDEHPNVIRY 86 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQ--FLVYQLLRGLKYIHSA 144 + +D Y+ L A L V+ + + ++ L++Q GL ++HS Sbjct: 87 F------CTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSL 140 Query: 145 GIIHRDLKPSNVAV---NEDCELR--ILDFGL------ARQADEEMTGYVATRWYRAPEI 193 I+HRDLKP N+ + N ++ I DFGL R + +G T + APE+ Sbjct: 141 NIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 200 Query: 194 MLNWMHYN--QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 + N TVDI+S GC+ ++ + P + + I+ +G + + Sbjct: 201 LSEDCKDNPTYTVDIFSAGCVFYYVI-SEGYHPFGKSLQRQANIL--LGACNLDCFHSDK 257 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 E + +A +L+ +M+ +D QR SA L H +F Sbjct: 258 HE------------------------DVIARELIEKMIAMDPQQRPSAKHVLKHPFF 290 >4EUU-A nrPDB Length = 319 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 61/246 (24%), Positives = 106/246 (43%), Gaps = 28/246 (11%) Query: 70 RELRLLKHLKHENVIGLLDVFTPATS-----IEDFSEVYLVTTLMGADLNNIVKCQALSD 124 RE +LK L H+N++ L + T+ I +F + T++ N L + Sbjct: 56 REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSN----AYGLPE 111 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNV--AVNEDCE--LRILDFGLARQA--DEE 178 ++ ++ G+ ++ GI+HR++KP N+ + ED + ++ DFG AR+ DE+ Sbjct: 112 SEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 171 Query: 179 MTGYVATRWYRAPEI----MLNWMH---YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQ 231 T Y P++ +L H Y TVD+WS+G G F + + Sbjct: 172 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRR 231 Query: 232 LKRIME--VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRML 289 K +M + G PS + +E+ I MP S+ RG L +L +L Sbjct: 232 NKEVMYKIITGKPSGAISGVQKAENGP--IDWSGDMPVS--CSLSRGLQVLLTPVLANIL 287 Query: 290 VLDSDQ 295 D ++ Sbjct: 288 EADQEK 293 >4EUT-A nrPDB Length = 396 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 61/246 (24%), Positives = 106/246 (43%), Gaps = 28/246 (11%) Query: 70 RELRLLKHLKHENVIGLLDVFTPATS-----IEDFSEVYLVTTLMGADLNNIVKCQALSD 124 RE +LK L H+N++ L + T+ I +F + T++ N L + Sbjct: 56 REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSN----AYGLPE 111 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNV--AVNEDCE--LRILDFGLARQA--DEE 178 ++ ++ G+ ++ GI+HR++KP N+ + ED + ++ DFG AR+ DE+ Sbjct: 112 SEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 171 Query: 179 MTGYVATRWYRAPEI----MLNWMH---YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQ 231 T Y P++ +L H Y TVD+WS+G G F + + Sbjct: 172 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRR 231 Query: 232 LKRIME--VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRML 289 K +M + G PS + +E+ I MP S+ RG L +L +L Sbjct: 232 NKEVMYKIITGKPSGAISGVQKAENGP--IDWSGDMPVS--CSLSRGLQVLLTPVLANIL 287 Query: 290 VLDSDQ 295 D ++ Sbjct: 288 EADQEK 293 >3C1X-A nrPDB Length = 373 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 59/246 (23%), Positives = 106/246 (43%), Gaps = 37/246 (15%) Query: 30 VGSGAYGSVCSAYDARL------RQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 +G G +G V Y L + AVK L+R + + E ++K H NV Sbjct: 97 IGRGHFGCV---YHGTLLDNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDFSHPNV 152 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVY--QLLRGLKYI 141 + LL + + S + ++ + DL N ++ + + + + Q+ +G+K++ Sbjct: 153 LSLLGICLRSEG----SPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFL 208 Query: 142 HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRWYRAPEIMLNWM-- 198 S +HRDL N ++E +++ DFGLAR D+E + P + WM Sbjct: 209 ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLP---VKWMAL 265 Query: 199 ------HYNQTVDIWSVGCIMAELLQGKA-------LFPGSDYIDQLKRIMEVVGTPSP- 244 + D+WS G ++ EL+ A F + Y+ Q +R+++ P P Sbjct: 266 ESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPL 325 Query: 245 -EVLAK 249 EV+ K Sbjct: 326 YEVMLK 331 >5UIU-A nrPDB Length = 323 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 96/205 (46%), Gaps = 20/205 (9%) Query: 26 GLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTY--RELRLLKHLKHENV 83 G +G G +G V Y VAVKKL+ + +E++++ +HEN+ Sbjct: 51 GGNKMGEGGFGVVYKGYVNN--TTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENL 108 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALS---DEHVQFLVYQ-LLRGLK 139 + LL + +D VY+ + L + + C + H++ + Q G+ Sbjct: 109 VELLGFSSDG---DDLCLVYVY--MPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN 163 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE----EMTG-YVATRWYRAPEIM 194 ++H IHRD+K +N+ ++E +I DFGLAR +++ MT V T Y APE + Sbjct: 164 FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL 223 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQG 219 + DI+S G ++ E++ G Sbjct: 224 RGEI--TPKSDIYSFGVVLLEIITG 246 >2PMN-X nrPDB Length = 348 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 59/255 (23%), Positives = 108/255 (42%), Gaps = 34/255 (13%) Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ----ALSDE 125 EL+++ +K+E + T I ++ EVY++ M D +I+K L Sbjct: 92 NELQIITDIKNEYCL------TCEGIITNYDEVYIIYEYMEND--SILKFDEYFFVLDKN 143 Query: 126 HVQFL--------VYQLLRGLKYIHS-AGIIHRDLKPSNVAVNEDCELRILDFGLAR-QA 175 + F+ + +L YIH+ I HRD+KPSN+ ++++ +++ DFG + Sbjct: 144 YTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMV 203 Query: 176 DEEMTGYVATRWYRAPEIMLNWMHYN-QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKR 234 D+++ G T + PE N YN VDIWS+G + + F + +L Sbjct: 204 DKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELFN 263 Query: 235 IMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSD 294 + P + H L P+ K + + ID L L + Sbjct: 264 NIRTKNIEYP-----LDRNHF------LYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPA 312 Query: 295 QRVSAAEALAHAYFS 309 +R+++ +AL H + + Sbjct: 313 ERITSEDALKHEWLA 327 >4OTD-A nrPDB Length = 341 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 35/121 (28%), Positives = 66/121 (54%), Gaps = 4/121 (3%) Query: 110 GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDF 169 G DL + S+ F ++ GL+++H I++RDLK N+ ++ + ++I DF Sbjct: 99 GGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADF 158 Query: 170 GLARQA---DEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGS 226 GL ++ + + + T + APE++ + Y + VD W +G ++ E+L G++ FPG Sbjct: 159 GLCKEGMGYGDRTSTFCGTPEFLAPEVLTD-TSYTRAVDWWGLGVLLYEMLVGESPFPGD 217 Query: 227 D 227 D Sbjct: 218 D 218 >3Q4U-A nrPDB Length = 301 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 98/220 (44%), Gaps = 32/220 (14%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLS-RPFQSLIHARRTYRELRLLKHL 78 V + + L VG G YG V + + VAVK S R +S Y + L Sbjct: 6 VARDITLLECVGKGRYGEVWRG--SWQGENVAVKIFSSRDEKSWFRETELYNTV----ML 59 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTL--MGADLNNIVKCQALSDEHVQFLVYQLLR 136 +HEN++G + + TS ++++L+T MG+ L + ++ L +V + Sbjct: 60 RHENILGF--IASDMTSRHSSTQLWLITHYHEMGS-LYDYLQLTTLDTVSCLRIVLSIAS 116 Query: 137 GLKYIH--------SAGIIHRDLKPSNVAVNEDCELRILDFGLA-------RQADEEMTG 181 GL ++H I HRDLK N+ V ++ + I D GLA Q D Sbjct: 117 GLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNP 176 Query: 182 YVATRWYRAPEIM-----LNWMHYNQTVDIWSVGCIMAEL 216 V T+ Y APE++ ++ + VDIW+ G ++ E+ Sbjct: 177 RVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEV 216 >4FL3-A nrPDB Length = 635 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 34/101 (33%), Positives = 57/101 (56%), Gaps = 9/101 (8%) Query: 122 LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR--QADE-- 177 + D+++ LV+Q+ G+KY+ + +HRDL NV + +I DFGL++ +ADE Sbjct: 466 VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENY 525 Query: 178 ---EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAE 215 + G +WY APE +N+ ++ D+WS G +M E Sbjct: 526 YKAQTHGKWPVKWY-APEC-INYYKFSSKSDVWSFGVLMWE 564 >2J0K-A nrPDB Length = 656 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 61/235 (25%), Positives = 107/235 (45%), Gaps = 22/235 (9%) Query: 22 QRLQGLRPVGSGAYGSVCSA-YDARLRQKVAVK-KLSRPFQSLIHARRTYRELRLLKHLK 79 +R++ R +G G +G V Y + +AV K + S + +E ++ Sbjct: 390 ERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFD 449 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDEHVQFLVY--QLLR 136 H +++ L+ V T + V+++ L +L + ++ + S + ++Y QL Sbjct: 450 HPHIVKLIGVITE-------NPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLST 502 Query: 137 GLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLARQADEEMTGYVATRW-----YRA 190 L Y+ S +HRD+ NV V+ DC +++ DFGL+R E+ T Y A++ + A Sbjct: 503 ALAYLESKRFVHRDIAARNVLVSATDC-VKLGDFGLSRYM-EDSTYYKASKGKLPIKWMA 560 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAE-LLQGKALFPGSDYIDQLKRIMEVVGTPSP 244 PE +N+ + D+W G M E L+ G F G D + RI P P Sbjct: 561 PE-SINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMP 614 >3PP0-A nrPDB Length = 338 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 56/207 (27%), Positives = 93/207 (44%), Gaps = 23/207 (11%) Query: 24 LQGLRPVGSGAYGSVCSAY----DARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 L+ ++ +GSGA+G+V ++ VA+K L R S + E ++ + Sbjct: 19 LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVL-RENTSPKANKEILDEAYVMAGVG 77 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQA-LSDEHVQFLVYQLLR 136 V LL + +T V LVT LM G L+++ + + L + + Q+ + Sbjct: 78 SPYVSRLLGICLTST-------VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAK 130 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT------GYVATRWYRA 190 G+ Y+ ++HRDL NV V ++I DFGLAR D + T G V +W Sbjct: 131 GMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMAL 190 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELL 217 I+ + D+WS G + EL+ Sbjct: 191 ESILRR--RFTHQSDVWSYGVTVWELM 215 >6NT9-A nrPDB Length = 742 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 61/246 (24%), Positives = 106/246 (43%), Gaps = 28/246 (11%) Query: 70 RELRLLKHLKHENVIGLLDVFTPATS-----IEDFSEVYLVTTLMGADLNNIVKCQALSD 124 RE +LK L H+N++ L + T+ I +F + T++ N L + Sbjct: 54 REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSN----AYGLPE 109 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNV--AVNEDCE--LRILDFGLARQA--DEE 178 ++ ++ G+ ++ GI+HR++KP N+ + ED + ++ DFG AR+ DE+ Sbjct: 110 SEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 169 Query: 179 MTGYVATRWYRAPEI----MLNWMH---YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQ 231 T Y P++ +L H Y TVD+WS+G G F + + Sbjct: 170 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRR 229 Query: 232 LKRIME--VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRML 289 K +M + G PS + +E+ I MP S+ RG L +L +L Sbjct: 230 NKEVMYKIITGKPSGAISGVQKAENGP--IDWSGDMPVS--CSLSRGLQVLLTPVLANIL 285 Query: 290 VLDSDQ 295 D ++ Sbjct: 286 EADQEK 291 >5XD6-A nrPDB Length = 305 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 97/214 (45%), Gaps = 38/214 (17%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLS---RPFQSLIHARRTYRELRLLKHLKHENVIGL 86 +G G+YG V + + A+KKL +P Q + ++ ++ L+ ENV+ L Sbjct: 30 IGEGSYGRVFYGI-LKSGKAAAIKKLDSSKQPDQEFL------AQVSMVSRLRQENVVAL 82 Query: 87 LDV------------FTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQL 134 L + P S+ D ++ + GA ++ + V+ V Sbjct: 83 LGYCVDGPLRVLAYEYAPNGSLHDI--LHGRKGVKGAQPGPVLSWH----QRVKIAV-GA 135 Query: 135 LRGLKYIHSAG---IIHRDLKPSNVAVNEDCELRILDFGLARQADE-----EMTGYVATR 186 RGL+Y+H +IHRD+K SNV + +D +I DF L+ QA + T + T Sbjct: 136 ARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTF 195 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGK 220 Y APE + ++ D++S G ++ ELL G+ Sbjct: 196 GYHAPEYAMTGTLSTKS-DVYSFGVVLLELLTGR 228 >4EBW-A nrPDB Length = 304 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 59/234 (25%), Positives = 106/234 (45%), Gaps = 20/234 (8%) Query: 22 QRLQGLRPVGSGAYGSVCSA-YDARLRQKVAVK-KLSRPFQSLIHARRTYRELRLLKHLK 79 +R++ R +G G +G V Y + +AV K + S + +E ++ Sbjct: 38 ERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFD 97 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDEHVQFLVY--QLLR 136 H +++ L+ V T + V+++ L +L + ++ + S + ++Y QL Sbjct: 98 HPHIVKLIGVITE-------NPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLST 150 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW-----YRAP 191 L Y+ S +HRD+ NV V+ + +++ DFGL+R E+ T Y A++ + AP Sbjct: 151 ALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM-EDSTYYKASKGKLPIKWMAP 209 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAE-LLQGKALFPGSDYIDQLKRIMEVVGTPSP 244 E +N+ + D+W G M E L+ G F G D + RI P P Sbjct: 210 E-SINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMP 262 >6FEX-A nrPDB Length = 321 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 49/192 (25%), Positives = 83/192 (43%), Gaps = 36/192 (18%) Query: 50 VAVKKLSRPFQSLIHARRTY-RELRLLKHLKHENVIGLLDVFT---PATSIEDFSEVYLV 105 VAVK L RP + +AR + +E++++ LK N+I LL V P I D+ E Sbjct: 60 VAVKIL-RP-DATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYME---- 113 Query: 106 TTLMGADLNNIVKCQALSDEHVQ--------------FLVYQLLRGLKYIHSAGIIHRDL 151 DLN + L D+ + + Q+ G++Y+ + +HRDL Sbjct: 114 ----NGDLNQFLSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDL 169 Query: 152 KPSNVAVNEDCELRILDFGLARQA------DEEMTGYVATRWYRAPEIMLNWMHYNQTVD 205 N V E+ ++I DFG++R + + RW I++ + D Sbjct: 170 ATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMG--KFTTASD 227 Query: 206 IWSVGCIMAELL 217 +W+ G + E+L Sbjct: 228 VWAFGVTLWEVL 239 >4G3E-A nrPDB Length = 352 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 57/200 (28%), Positives = 90/200 (45%), Gaps = 23/200 (11%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 VG G++G V D + + AVKK+ + R EL L ++ L Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVR------LEVFRV-EELVACAGLSSPRIVPLYGA 134 Query: 90 FTPATSIEDFSEVYLVTTLMGADLNNIVK-CQALSDEHVQFLVYQLLRGLKYIHSAGIIH 148 + F E+ L G L ++K L ++ + + Q L GL+Y+H+ I+H Sbjct: 135 VREGPWVNIFMEL-----LEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILH 189 Query: 149 RDLKPSNVAVNED-CELRILDFG--LARQAD----EEMTG-YV-ATRWYRAPEIMLNWMH 199 D+K NV ++ D + DFG L Q D +TG Y+ T + APE+++ Sbjct: 190 GDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMG-KP 248 Query: 200 YNQTVDIWSVGCIMAELLQG 219 + VDIWS C+M +L G Sbjct: 249 CDAKVDIWSSCCMMLHMLNG 268 >4HVI-A nrPDB Length = 314 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 63/234 (26%), Positives = 110/234 (47%), Gaps = 29/234 (12%) Query: 14 NKTVWEVPQRLQGLRPVGSGAYGSV-CSAYDA---RLRQKVAVKKL--SRPFQSLIHARR 67 + T++E + L+ + +G G +GSV YD VAVK+L S P Q R Sbjct: 3 DPTIFE-ERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQ----RD 57 Query: 68 TYRELRLLKHLKHENVIGLLDV-FTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEH 126 RE+++LK L + ++ V + P YL + L + ++ + Sbjct: 58 FQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGC----LRDFLQRHRARLDA 113 Query: 127 VQFLVY--QLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVA 184 + L+Y Q+ +G++Y+ S +HRDL N+ V + ++I DFGLA+ + YV Sbjct: 114 SRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVV 173 Query: 185 TR-------WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ--GKALFPGSDYI 229 WY APE + + + Q+ D+WS G ++ EL K+ P ++++ Sbjct: 174 REPGQSPIFWY-APESLSDNIFSRQS-DVWSFGVVLYELFTYCDKSCSPSAEFL 225 >4C59-A nrPDB Length = 340 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 57/217 (26%), Positives = 94/217 (43%), Gaps = 28/217 (12%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK-HE 81 RL+ R + G + V A D ++ A+K+L + R +E+ +K L H Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEE--KNRAIIQEVCFMKKLSGHP 85 Query: 82 NVIGLLDVFTPATSIEDF--SEVYLVTTLMGADLNNIVKCQA----LSDEHVQFLVYQLL 135 N++ + D +E L+T L L +K LS + V + YQ Sbjct: 86 NIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTC 145 Query: 136 RGLKYIHSAG--IIHRDLKPSNVAVNEDCELRILDFGLA---------------RQADEE 178 R ++++H IIHRDLK N+ ++ +++ DFG A R EE Sbjct: 146 RAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEE 205 Query: 179 MTGYVATRWYRAPEIMLNWMHY--NQTVDIWSVGCIM 213 T YR PEI+ + ++ + DIW++GCI+ Sbjct: 206 EITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCIL 242 >2QLU-A nrPDB Length = 314 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 100/220 (45%), Gaps = 33/220 (15%) Query: 26 GLRPVGS------GAYGSVCSAYDARLRQK-VAVKKLSRPFQSLIHARRTYRELRLLKHL 78 GL P GS A G + A+L VAVK P Q + ++ RE+ + Sbjct: 10 GLVPRGSLQLLEIKARGRFGCVWKAQLMNDFVAVKIF--PLQDK-QSWQSEREIFSTPGM 66 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDEHVQFLVYQLLRG 137 KHEN++ + +++E E++L+T L + +K ++ + + + RG Sbjct: 67 KHENLLQFIAAEKRGSNLE--VELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRG 124 Query: 138 LKYIH-----------SAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD-----EEMTG 181 L Y+H I HRD K NV + D + DFGLA + + + G Sbjct: 125 LSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHG 184 Query: 182 YVATRWYRAPEIMLNWMHYNQT----VDIWSVGCIMAELL 217 V TR Y APE++ +++ + +D++++G ++ EL+ Sbjct: 185 QVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELV 224 >3V5Q-A nrPDB Length = 297 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 56/221 (25%), Positives = 90/221 (40%), Gaps = 43/221 (19%) Query: 28 RPVGSGAYGSVCSAYDARL-----RQKVAVKKLSRPFQSLIHARRTY-RELRLLKHLKHE 81 R +G GA+G V A L + VAVK L P + AR+ + RE LL +L+HE Sbjct: 21 RELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDP---TLAARKDFQREAELLTNLQHE 77 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-----------------LSD 124 +++ V + + + + DLN ++ L Sbjct: 78 HIVKFYGVCGDGDPL-----IMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGL 132 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY-- 182 + + Q+ G+ Y+ S +HRDL N V + ++I DFG++R D T Y Sbjct: 133 SQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSR--DVYSTDYYR 190 Query: 183 ------VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 + RW IM + + D+WS G I+ E+ Sbjct: 191 VGGHTMLPIRWMPPESIM--YRKFTTESDVWSFGVILWEIF 229 >5C26-A nrPDB Length = 299 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 34/101 (33%), Positives = 57/101 (56%), Gaps = 9/101 (8%) Query: 122 LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR--QADE-- 177 + D+++ LV+Q+ G+KY+ + +HRDL NV + +I DFGL++ +ADE Sbjct: 124 VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENY 183 Query: 178 ---EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAE 215 + G +WY APE +N+ ++ D+WS G +M E Sbjct: 184 YKAQTHGKWPVKWY-APEC-INYYKFSSKSDVWSFGVLMWE 222 >5B2L-A nrPDB Length = 324 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 100/210 (47%), Gaps = 17/210 (8%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 L+ L +GSG G V + +AVK++ R +R +L ++ LK + Sbjct: 19 LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKE-ENKRILMDLDVV--LKSHDC 75 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA--LSDEHVQFLVYQLLRGLKYI 141 ++ F T I + ++V++ LMG + K + + + + +++ L Y+ Sbjct: 76 PYIVQCF--GTFITN-TDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYYL 132 Query: 142 HSA-GIIHRDLKPSNVAVNEDCELRILDFGLA-RQADEEM-TGYVATRWYRAPEIM---- 194 G+IHRD+KPSN+ ++E ++++ DFG++ R D + T Y APE + Sbjct: 133 KEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPD 192 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKALFP 224 Y+ D+WS+G + EL G+ FP Sbjct: 193 PTKPDYDIRADVWSLGISLVELATGQ--FP 220 >6O8B-A nrPDB Length = 665 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 61/246 (24%), Positives = 106/246 (43%), Gaps = 28/246 (11%) Query: 70 RELRLLKHLKHENVIGLLDVFTPATS-----IEDFSEVYLVTTLMGADLNNIVKCQALSD 124 RE +LK L H+N++ L + T+ I +F + T++ N L + Sbjct: 62 REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSN----AYGLPE 117 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNV--AVNEDCE--LRILDFGLARQA--DEE 178 ++ ++ G+ ++ GI+HR++KP N+ + ED + ++ DFG AR+ DE+ Sbjct: 118 SEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 177 Query: 179 MTGYVATRWYRAPEI----MLNWMH---YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQ 231 T Y P++ +L H Y TVD+WS+G G F + + Sbjct: 178 FVELYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRR 237 Query: 232 LKRIME--VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRML 289 K +M + G PS + +E+ I MP S+ RG L +L +L Sbjct: 238 NKEVMYKIITGKPSGAISGVQKAENGP--IDWSGDMPVS--CSLSRGLQVLLTPVLANIL 293 Query: 290 VLDSDQ 295 D ++ Sbjct: 294 EADQEK 299 >2OZO-A nrPDB Length = 613 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 64/243 (26%), Positives = 111/243 (45%), Gaps = 34/243 (13%) Query: 30 VGSGAYGSVCSAYDARLRQK---VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 +G G +GSV R+R+K VA+K L + + RE +++ L + ++ L Sbjct: 344 LGCGNFGSVRQGV-YRMRKKQIDVAIKVLKQGTEK-ADTEEMMREAQIMHQLDNPYIVRL 401 Query: 87 LDVFTPATSIEDFSEVYLVTTLM--GADLNNIV--KCQALSDEHVQFLVYQLLRGLKYIH 142 + V +E ++ M G L+ + K + + +V L++Q+ G+KY+ Sbjct: 402 IGVCQ--------AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVAT-------RWYRAPEIML 195 +HR+L NV + +I DFGL++ + + Y A +WY APE + Sbjct: 454 EKNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APEC-I 511 Query: 196 NWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSD------YIDQLKRIMEVVGTPSPEVLA 248 N+ ++ D+WS G M E L G+ + +I+Q KR ME PE+ A Sbjct: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKR-MECPPECPPELYA 570 Query: 249 KIS 251 +S Sbjct: 571 LMS 573 >3HNG-A nrPDB Length = 360 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 37/120 (30%), Positives = 61/120 (50%), Gaps = 17/120 (14%) Query: 132 YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAP 191 +Q+ RG++++ S IHRDL N+ ++E+ ++I DFGLAR + YV R P Sbjct: 206 FQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKN-PDYVRKGDTRLP 264 Query: 192 EIMLNWMH--------YNQTVDIWSVGCIMAELLQ-GKALFPG----SDYIDQLKRIMEV 238 L WM Y+ D+WS G ++ E+ G + +PG D+ +L+ M + Sbjct: 265 ---LKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRM 321 >6BSD-A nrPDB Length = 876 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 47/195 (24%), Positives = 85/195 (43%), Gaps = 36/195 (18%) Query: 50 VAVKKLSRPFQSLIHARRTY-RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTL 108 VAVK L RP + +AR + +E++++ LK N+I LL V ++D + + Sbjct: 615 VAVKIL-RP-DATKNARNDFLKEVKIMSRLKDPNIIRLLGV-----CVQDDPLCMITDYM 667 Query: 109 MGADLNNIVKCQALSDEHVQ--------------------FLVYQLLRGLKYIHSAGIIH 148 DLN + L D+ + + Q+ G++Y+ + +H Sbjct: 668 ENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVH 727 Query: 149 RDLKPSNVAVNEDCELRILDFGLARQ--ADE----EMTGYVATRWYRAPEIMLNWMHYNQ 202 RDL N V E+ ++I DFG++R A + + + RW I++ + Sbjct: 728 RDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMG--KFTT 785 Query: 203 TVDIWSVGCIMAELL 217 D+W+ G + E+L Sbjct: 786 ASDVWAFGVTLWEVL 800 >1U59-A nrPDB Length = 287 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 54/202 (26%), Positives = 94/202 (46%), Gaps = 26/202 (12%) Query: 30 VGSGAYGSVCSAYDARLRQK---VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 +G G +GSV R+R+K VA+K L + + RE +++ L + ++ L Sbjct: 18 LGCGNFGSVRQGV-YRMRKKQIDVAIKVLKQGTEK-ADTEEMMREAQIMHQLDNPYIVRL 75 Query: 87 LDVFTPATSIEDFSEVYLVTTLM--GADLNNIV--KCQALSDEHVQFLVYQLLRGLKYIH 142 + V +E ++ M G L+ + K + + +V L++Q+ G+KY+ Sbjct: 76 IGVCQ--------AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 127 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVAT-------RWYRAPEIML 195 +HRDL NV + +I DFGL++ + + Y A +WY APE + Sbjct: 128 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APEC-I 185 Query: 196 NWMHYNQTVDIWSVGCIMAELL 217 N+ ++ D+WS G M E L Sbjct: 186 NFRKFSSRSDVWSYGVTMWEAL 207 >3LZB-A nrPDB Length = 327 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 101/207 (48%), Gaps = 23/207 (11%) Query: 24 LQGLRPVGSGAYGSVCSAY----DARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 + ++ +GSGA+G+V +++ VA+K+L R S + E ++ + Sbjct: 17 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASVD 75 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQ-ALSDEHVQFLVYQLLR 136 + +V LL + +T V L+T LM G L+ + + + + +++ Q+ + Sbjct: 76 NPHVCRLLGICLTST-------VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAK 128 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT------GYVATRWYRA 190 G+ Y+ ++HRDL NV V ++I DFGLA+ E G V +W A Sbjct: 129 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM-A 187 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELL 217 E +L+ ++ +Q+ D+WS G + EL+ Sbjct: 188 LESILHRIYTHQS-DVWSYGVTVWELM 213 >4E20-A nrPDB Length = 290 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 88/206 (42%), Gaps = 19/206 (9%) Query: 24 LQGLRPVGSGAYGSVC-SAYDAR---LRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 L+ +R +G G +G V YD + VAVK L + + RE+ +L+ L Sbjct: 10 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQ-REIEILRTLY 68 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDEHVQFLVYQLLRGL 138 HE+++ + + V LV + L + + + + Q+ G+ Sbjct: 69 HEHIVK----YKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGM 124 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATR-------WYRAP 191 Y+H+ IHR L NV ++ D ++I DFGLA+ E Y WY AP Sbjct: 125 AYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-AP 183 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELL 217 E + Y + D+WS G + ELL Sbjct: 184 ECLKECKFYYAS-DVWSFGVTLYELL 208 >2QKW-B nrPDB Length = 321 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 53/201 (26%), Positives = 92/201 (45%), Gaps = 17/201 (8%) Query: 30 VGSGAYGSVCSAYDARLRQ--KVAVKKLS-RPFQSLIHARRTYRELRLLKHLKHENVIGL 86 +G G +G V Y LR KVA+K+ + Q + L +H ++IG Sbjct: 47 IGHGVFGKV---YKGVLRDGAKVALKRRTPESSQGIEEFETEIETLSFCRHPHLVSLIGF 103 Query: 87 LDVFTPATSIEDFSEV-YLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAG 145 D I + E L L G+DL + ++S E + RGL Y+H+ Sbjct: 104 CDERNEMILIYKYMENGNLKRHLYGSDLPTM----SMSWEQRLEICIGAARGLHYLHTRA 159 Query: 146 IIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVA-----TRWYRAPEIMLNWMHY 200 IIHRD+K N+ ++E+ +I DFG++++ E +++ T Y PE + Sbjct: 160 IIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKG-RL 218 Query: 201 NQTVDIWSVGCIMAELLQGKA 221 + D++S G ++ E+L ++ Sbjct: 219 TEKSDVYSFGVVLFEVLCARS 239 >2VD5-A nrPDB Length = 412 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 48/190 (25%), Positives = 87/190 (45%), Gaps = 13/190 (6%) Query: 95 SIEDFSEVYLVTTL-MGADLNNIVK--CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDL 151 + +D + +YLV +G DL ++ + + E +F + +++ + +H G +HRD+ Sbjct: 129 AFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDI 188 Query: 152 KPSNVAVNEDCELRILDFG--LARQADEEMTGYVA--TRWYRAPEIM------LNWMHYN 201 KP N+ ++ +R+ DFG L +AD + VA T Y +PEI+ Y Sbjct: 189 KPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYG 248 Query: 202 QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQS 261 D W++G E+ G+ F + +I+ S ++ + E AR +IQ Sbjct: 249 PECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQR 308 Query: 262 LPPMPQKDLS 271 L P+ L Sbjct: 309 LLCPPETRLG 318 >5GNK-A nrPDB Length = 297 Score = 54.7 bits (130), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 53/207 (25%), Positives = 100/207 (48%), Gaps = 23/207 (11%) Query: 24 LQGLRPVGSGAYGSVCSAY----DARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 + ++ +GSGA+G+V +++ VA+K+L R S + E ++ + Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASVD 79 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQ-ALSDEHVQFLVYQLLR 136 + +V LL + +T V L+ LM G L+ + + + + +++ Q+ + Sbjct: 80 NPHVCRLLGICLTST-------VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAK 132 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT------GYVATRWYRA 190 G+ Y+ ++HRDL NV V ++I DFGLA+ E G V +W A Sbjct: 133 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM-A 191 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELL 217 E +L+ ++ +Q+ D+WS G + EL+ Sbjct: 192 LESILHRIYTHQS-DVWSYGVTVWELM 217 >1LUF-A nrPDB Length = 343 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 56/228 (24%), Positives = 91/228 (39%), Gaps = 34/228 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLR-----QKVAVKKLSRPFQSLIHARRTYRELRLLK 76 ++ +R +G GA+G V A L VAVK L + + A RE L+ Sbjct: 47 NNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQ-REAALMA 105 Query: 77 HLKHENVIGLLDVFTPATSI---------EDFSEV------YLVTTLMGADLNNIVKCQA 121 + N++ LL V + D +E + V +L +DL+ + + Sbjct: 106 EFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSS 165 Query: 122 -----LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ-- 174 LS + Q+ G+ Y+ +HRDL N V E+ ++I DFGL+R Sbjct: 166 PGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIY 225 Query: 175 -AD---EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ 218 AD + + RW I N Y D+W+ G ++ E+ Sbjct: 226 SADYYKADGNDAIPIRWMPPESIFYN--RYTTESDVWAYGVVLWEIFS 271 >4XLV-A nrPDB Length = 328 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 58/227 (25%), Positives = 97/227 (42%), Gaps = 41/227 (18%) Query: 18 WEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQ--------KVAVKKLSRPFQSLIHARRT 68 WEV +++ LR +G G++G V Y+ R +VAVK ++ SL Sbjct: 34 WEVSREKITLLRELGQGSFGMV---YEGNARDIIKGEAETRVAVKTVNES-ASLRERIEF 89 Query: 69 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADL------------NN 115 E ++K +V+ LL V + +V LM DL NN Sbjct: 90 LNEASVMKGFTCHHVVRLLGVVSKGQP------TLVVMELMAHGDLKSYLRSLRPEAENN 143 Query: 116 IVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA 175 + E +Q + ++ G+ Y+++ +HRDL N V D ++I DFG+ R Sbjct: 144 PGRPPPTLQEMIQ-MAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI 202 Query: 176 DEE------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAEL 216 E G + RW APE + + + + + D+WS G ++ E+ Sbjct: 203 YETDYYRKGGKGLLPVRWM-APESLKDGV-FTTSSDMWSFGVVLWEI 247 >5WNO-A nrPDB Length = 330 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 47/210 (22%), Positives = 96/210 (45%), Gaps = 37/210 (17%) Query: 28 RPVGSGAYGSVCSA-YDARLRQKVAVKKLSRPFQS--------LIHARRTYRE-----LR 73 + +G+GA+G+V + Y + + V + + FQ+ L A +R L+ Sbjct: 28 KKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLK 87 Query: 74 LLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQ 133 ++ H++ + ++ ++ P ++++F +++ +GA ++ C YQ Sbjct: 88 IIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKEN--LGAR-EQVLYC------------YQ 132 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM------TGYVATRW 187 + G++Y+ ++HRDL NV V + + I DFGL++ + +G VA +W Sbjct: 133 IASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKW 192 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 A EI Y D+W+ G E++ Sbjct: 193 L-AIEIFSKHC-YTHASDVWAFGVTCWEII 220 >3M42-A nrPDB Length = 299 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 48/197 (24%), Positives = 91/197 (46%), Gaps = 35/197 (17%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRL-LKHLKHENVIGLLD 88 +G G G V ++ R ++K A+K L Q ARR E+ L + + +++ ++D Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKML----QDCPKARR---EVELHWRASQCPHIVRIVD 78 Query: 89 VFTPATSIEDFSEVYLVTTLMGADLNNIVKC---QALSDEHVQFLVYQLLRGLKYIHSAG 145 V+ + + ++ L G +L + ++ QA ++ ++ + ++Y+HS Sbjct: 79 VYENLYAGRK-CLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 137 Query: 146 IIHRDLKPSNVAVNE---DCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQ 202 I HRD+KP N+ + L++ DFG A++ E Y++ Sbjct: 138 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGE--------------------KYDK 177 Query: 203 TVDIWSVGCIMAELLQG 219 + D+WS+G IM LL G Sbjct: 178 SCDMWSLGVIMYILLCG 194 >3ZZW-A nrPDB Length = 289 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 60/204 (29%), Positives = 97/204 (47%), Gaps = 26/204 (12%) Query: 48 QKVAVKKLSRPFQSLIHARRTYRELRLLK-HLKHENVIGLLDVFT---PATSI------E 97 Q VA+K L + + R +R +L+ L+H NV+ LL V T P + I Sbjct: 40 QAVAIKTLKDKAEGPL--REEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHG 97 Query: 98 DFSEVYLV----TTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKP 153 D E ++ + + D + VK AL LV Q+ G++Y+ S ++H+DL Sbjct: 98 DLHEFLVMRSPHSDVGSTDDDRTVK-SALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLAT 156 Query: 154 SNVAVNEDCELRILDFGLARQ---AD-EEMTG--YVATRWYRAPEIMLNWMHYNQTVDIW 207 NV V + ++I D GL R+ AD ++ G + RW APE ++ + ++ DIW Sbjct: 157 RNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWM-APEAIM-YGKFSIDSDIW 214 Query: 208 SVGCIMAELLQGKALFPGSDYIDQ 231 S G ++ E+ L P Y +Q Sbjct: 215 SYGVVLWEVFS-YGLQPYCGYSNQ 237 >3QUP-A nrPDB Length = 323 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 55/224 (24%), Positives = 95/224 (42%), Gaps = 36/224 (16%) Query: 28 RPVGSGAYGSVCSAYDARLRQ------KVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 R +G G +GSV +A+L+Q KVAVK L + RE +K H Sbjct: 29 RMLGKGEFGSV---REAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHP 85 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDEHVQFLVYQLLR---- 136 +V L+ V + + ++ M DL+ + + + + L+R Sbjct: 86 HVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMVD 145 Query: 137 ---GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYR---A 190 G++Y+ S IHRDL N + ED + + DFGL+R+ + +YR A Sbjct: 146 IACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKI-------YSGDYYRQGCA 198 Query: 191 PEIMLNWMH--------YNQTVDIWSVGCIMAELL-QGKALFPG 225 ++ + W+ Y D+W+ G M E++ +G+ + G Sbjct: 199 SKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAG 242 >4CI6-B nrPDB Length = 643 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 44/184 (23%), Positives = 91/184 (49%), Gaps = 22/184 (11%) Query: 127 VQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNE-DCELRILDFGLARQADEEMTGYVAT 185 ++F+ ++LL ++ AGI+H D+KP NV + E ++D GL ++ E+ G+ T Sbjct: 158 IKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGF--T 215 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245 ++APE+ + + ++ D++ +++ LL G I+ ++ E+ P+ + Sbjct: 216 ESFKAPELGVGNLGASEKSDVF---LVVSTLLHG---------IEGFEKDPEI--KPN-Q 260 Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAH 305 L I+SE A ++ P+ + ++ + D+LG + +D R + EA H Sbjct: 261 GLRFITSEPAHVMDENGYPIHRPGIAGVETAYTRFITDILG----VSADSRPDSNEARLH 316 Query: 306 AYFS 309 + S Sbjct: 317 EFLS 320 >3BBT-B nrPDB Length = 328 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 57/221 (25%), Positives = 99/221 (44%), Gaps = 33/221 (14%) Query: 24 LQGLRPVGSGAYGSVCSAY----DARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 L+ ++ +GSGA+G+V ++ VA+K L+ + E ++ + Sbjct: 17 LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVE-FMDEALIMASMD 75 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQ-ALSDEHVQFLVYQLLR 136 H +++ LL V T + LVT LM G L + + + + + + Q+ + Sbjct: 76 HPHLVRLLGVCLSPT-------IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAK 128 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR--QADEEM----TGYVATRWYRA 190 G+ Y+ ++HRDL NV V ++I DFGLAR + DE+ G + +W Sbjct: 129 GMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKW--- 185 Query: 191 PEIMLNWMHYNQTV---DIWSVGCIMAELLQGKALFPGSDY 228 + L +HY + D+WS G + EL+ F G Y Sbjct: 186 --MALECIHYRKFTHQSDVWSYGVTIWELMT----FGGKPY 220 >4LQP-A nrPDB Length = 508 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 40/152 (26%), Positives = 79/152 (51%), Gaps = 15/152 (9%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE-NVIG 85 ++ +G GA+G V RL QK K+ ++L+ + ++ L H+K E +V+ Sbjct: 107 VKVIGKGAFGEV------RLVQKKDTGKIY-AMKTLLKSEMYKKDQ--LAHVKAERDVLA 157 Query: 86 LLD---VFTPATSIEDFSEVYLVTTLM-GADLNN-IVKCQALSDEHVQFLVYQLLRGLKY 140 D V + S +D +YL+ + G DL +++ Q +++ +F + + + ++ Sbjct: 158 GSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIET 217 Query: 141 IHSAGIIHRDLKPSNVAVNEDCELRILDFGLA 172 IH G IHR +KP N+ ++ +++ DFGL+ Sbjct: 218 IHKLGFIHRAIKPDNILIDIRGHIKLSDFGLS 249 Score = 34.3 bits (77), Expect = 0.098, Method: Compositional matrix adjust. Identities = 23/59 (38%), Positives = 28/59 (47%), Gaps = 1/59 (1%) Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGT 241 V T Y APEI L + Y Q D WS+G IM E L G F + ++IM T Sbjct: 324 VGTPDYIAPEIFL-YQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQT 381 >5X1R-A nrPDB Length = 302 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 41/169 (24%), Positives = 73/169 (43%), Gaps = 32/169 (18%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVK---------------------KLSRPFQSLIHARRT 68 +G G +G V AYD +L + +A+K + + FQ+ +++ Sbjct: 29 IGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQAGLNS--F 86 Query: 69 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQ--ALSDE 125 +E RLL H ++ +L + E+ Y+ T G L N+ Q + + Sbjct: 87 IQEARLLARFSHPGLLHVLRFW------EENGTAYMGTQFYSGTTLKNLQAQQPEKIDEA 140 Query: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ 174 ++ L+ L + IH G +HRD+ N+ + E +LDFG AR+ Sbjct: 141 WIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARK 189 >4LRM-A nrPDB Length = 334 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 54/210 (25%), Positives = 101/210 (48%), Gaps = 26/210 (12%) Query: 24 LQGLRPVGSGAYGSVCSAY----DARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 + ++ +GSGA+G+V +++ VA+K+L R S + E ++ + Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASVD 79 Query: 80 HE---NVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQ-ALSDEHVQFLVYQ 133 + +V LL + +T V L+T LM G L+ + + + + +++ Q Sbjct: 80 NPGNPHVCRLLGICLTST-------VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ 132 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT------GYVATRW 187 + +G+ Y+ ++HRDL NV V ++I DFGLA+ E G V +W Sbjct: 133 IAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW 192 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 A E +L+ ++ +Q+ D+WS G + EL+ Sbjct: 193 M-ALESILHRIYTHQS-DVWSYGVTVWELM 220 >2WTK-B nrPDB Length = 373 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 62/270 (22%), Positives = 112/270 (41%), Gaps = 36/270 (13%) Query: 71 ELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEH---- 126 EL + K H N++ AT I D +E+++VT+ M + C D Sbjct: 60 ELHVSKLFNHPNIVPYR-----ATFIAD-NELWVVTSFMAYGSAKDLICTHFMDGMNELA 113 Query: 127 VQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED---------CELRILDFGLARQADE 177 + +++ +L+ L YIH G +HR +K S++ ++ D L ++ G ++ Sbjct: 114 IAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVH 173 Query: 178 EMTGY-VATRWYRAPEIM-LNWMHYNQTVDIWSVGCIMAELLQGKALF---PGSDYI--- 229 + Y V + +PE++ N Y+ DI+SVG EL G F P + + Sbjct: 174 DFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEK 233 Query: 230 --DQLKRIMEVVGTPSPEVLAKISSEHART----YIQSLPPMPQKDLS---SIFRGANPL 280 + +++ P+ E+ S A + + + P P S R +P Sbjct: 234 LNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPH 293 Query: 281 AIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + + L + D R SA+ L H++F Q Sbjct: 294 FHHFVEQCLQRNPDARPSASTLLNHSFFKQ 323 >2C47-A nrPDB Length = 313 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 61/254 (24%), Positives = 110/254 (43%), Gaps = 32/254 (12%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 + +G G +G + + + VA+K P +S A + + E R K L + + Sbjct: 10 KKIGCGNFGELRLGKNLYTNEYVAIK--LEPIKS--RAPQLHLEYRFYKQLSATEGVPQV 65 Query: 88 DVFTPATSIEDFSEVYLVTTLMGADLNNIVK-C-QALSDEHVQFLVYQLLRGLKYIHSAG 145 F P +V L+G L ++ C + + + V + QL+ ++Y+H+ Sbjct: 66 YYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKS 120 Query: 146 IIHRDLKPSNVAVNEDCELR-----ILDFGLARQ-ADEEMTGYVATRWYRAPEIMLNWMH 199 +I+RD+KP N V R I+DFGLA++ D E ++ R +++ +M Sbjct: 121 LIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMS 180 Query: 200 YNQTV--------DIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG-----TPSPEV 246 N + D+ ++G + L+G + G D LK + +G TP EV Sbjct: 181 INTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDTKRATPI-EV 238 Query: 247 LAKISSEHARTYIQ 260 L + E TY++ Sbjct: 239 LCENFPEEMATYLR 252 >5IKW-A nrPDB Length = 310 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 51/172 (29%), Positives = 77/172 (44%), Gaps = 31/172 (18%) Query: 70 RELRLLKHLK-HENVIGLLDVFTPATSIEDFSEVYLVTTLM-----GADLNNIVKC--QA 121 RE+ ++K L H+N++G LD SI D V+ V LM G +N + K Sbjct: 59 REITIMKELSGHKNIVGYLD--CAVNSISD--NVWEVLILMEYCRAGQVVNQMNKKLQTG 114 Query: 122 LSDEHVQFLVYQLLRGLKYIHSAG--IIHRDLKPSNVAVNEDCELRILDFGLARQ----- 174 ++ V + + +H IIHRDLK N+ +N+ + DFG A Sbjct: 115 FTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNP 174 Query: 175 -------ADEEMTGYVATRWYRAPEIMLNWMH---YNQTVDIWSVGCIMAEL 216 +EE+ Y T YRAPE M+N DIW++GC++ +L Sbjct: 175 QKDGVNVVEEEIKKY-TTLSYRAPE-MINLYGGKPITTKADIWALGCLLYKL 224 >5CLR-A nrPDB Length = 451 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 33/124 (26%), Positives = 61/124 (49%), Gaps = 8/124 (6%) Query: 103 YLVTTLM-GADLNNIVKCQALSDEHVQF-----LVYQLLRGLKYIHSAGIIHRDLKPSNV 156 Y++TT + G DL+ L+ F ++ + +K H G+IHRDLKP N+ Sbjct: 148 YILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNI 207 Query: 157 AVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMA 214 ++ D + ++DFG + E T Y APE+ +++ ++Q D++++ + Sbjct: 208 MLDADMQCHLVDFGSSSSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAYSLD 267 Query: 215 ELLQ 218 EL Sbjct: 268 ELFN 271 >2Y4I-B nrPDB Length = 319 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 40/159 (25%), Positives = 81/159 (50%), Gaps = 16/159 (10%) Query: 18 WEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLK 76 W++P ++L+ +G G +G V Y R +VA++ + + + RE+ + Sbjct: 28 WDIPFEQLEIGELIGKGRFGQV---YHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYR 84 Query: 77 HLKHENVIGLLD-VFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQ--ALSDEHVQFLVY 132 +HENV+ + +P + ++T+L G L ++V+ L + + Sbjct: 85 QTRHENVVLFMGACMSPP-------HLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQ 137 Query: 133 QLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGL 171 ++++G+ Y+H+ GI+H+DLK NV ++ ++ I DFGL Sbjct: 138 EIVKGMGYLHAKGILHKDLKSKNV-FYDNGKVVITDFGL 175 >5L2Q-C nrPDB Length = 320 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 58/239 (24%), Positives = 110/239 (46%), Gaps = 49/239 (20%) Query: 73 RLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNN----IVKCQALSDEHVQ 128 R++K +K + + +LD DFS+ ADL N ++K + LS+ Sbjct: 109 RMVKKMK-KRICLVLDCLCA----HDFSD-------KTADLINLQHYVIKEKRLSERETV 156 Query: 129 FLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE-LRILDFGLARQADEE---MTGYVA 184 + Y ++R ++ +H I+HRDLK N+ +N+ + I +F L + E + Sbjct: 157 VIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRG 216 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSP 244 + Y +P+++ + + D+W++G ++ +L G+ FP D I Q Sbjct: 217 SPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQ--FPFYDSIPQ------------- 261 Query: 245 EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEAL 303 E+ KI A Y ++P + +++ L+ ++LVLD QR++AA+ L Sbjct: 262 ELFRKIK---AAEY--TIPEDGRVSENTVC---------LIRKLLVLDPQQRLAAADVL 306 >4RT7-A nrPDB Length = 415 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 34/114 (29%), Positives = 55/114 (48%), Gaps = 11/114 (9%) Query: 120 QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM 179 L+ E + YQ+ +G++++ +HRDL NV V ++I DFGLAR + Sbjct: 238 NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD- 296 Query: 180 TGYVA-------TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPG 225 + YV +W APE + + Y D+WS G ++ E+ G +PG Sbjct: 297 SNYVVRGNARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFSLGVNPYPG 348 >5KMM-A nrPDB Length = 329 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 53/216 (24%), Positives = 89/216 (41%), Gaps = 38/216 (17%) Query: 30 VGSGAYGSVCSAYDARL-----RQKVAVKKLSRPFQSLIHARRTY-RELRLLKHLKHENV 83 +G GA+G V A L + VAVK L +S AR+ + RE LL L+H+++ Sbjct: 43 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASES---ARQDFQREAELLTMLQHQHI 99 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA----------------LSDEHV 127 + V T + + + + DLN ++ L + Sbjct: 100 VRFFGVCTEGRPL-----LMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQL 154 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR---QADEEMTG--- 181 + Q+ G+ Y+ +HRDL N V + ++I DFG++R D G Sbjct: 155 LAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT 214 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 + RW PE +L + + D+WS G ++ E+ Sbjct: 215 MLPIRWM-PPESIL-YRKFTTESDVWSFGVVLWEIF 248 >5FQD-C nrPDB Length = 341 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 44/174 (25%), Positives = 88/174 (50%), Gaps = 18/174 (10%) Query: 14 NKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ--SLIHARRTYRE 71 +K + V + + +R +GSG++G + A + ++VAVK S+ + L++ + Y+ Sbjct: 11 SKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKI 70 Query: 72 LRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--CQALSDEHVQF 129 L+ + H G +D++ LV L+G L ++ + + + V Sbjct: 71 LQGGVGIPHIRWYG---------QEKDYN--VLVMDLLGPSLEDLFNFCSRRFTMKTVLM 119 Query: 130 LVYQLLRGLKYIHSAGIIHRDLKPSN--VAVNEDC-ELRILDFGLARQADEEMT 180 L Q++ ++Y+H+ IHRD+KP N + + C +L ++DFGLA++ + T Sbjct: 120 LADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRT 173 >3SV0-A nrPDB Length = 483 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 40/162 (24%), Positives = 77/162 (47%), Gaps = 22/162 (13%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVK----KLSRPFQSLIHARRTYRELRLLKHLKHENV 83 R +GSG++G + + + ++VA+K K P L++ + YR L+ + + Sbjct: 13 RKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHP--QLLYESKIYRILQGGTGIPNVRW 70 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--CQALSDEHVQFLVYQLLRGLKYI 141 G+ + LV L+G L ++ + LS + V L Q++ ++++ Sbjct: 71 FGVEGDYN-----------VLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFV 119 Query: 142 HSAGIIHRDLKPSNVAVN---EDCELRILDFGLARQADEEMT 180 HS +HRD+KP N + ++ I+DFGLA++ + T Sbjct: 120 HSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTST 161 >5U6C-A nrPDB Length = 315 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 55/219 (25%), Positives = 97/219 (44%), Gaps = 27/219 (12%) Query: 28 RPVGSGAYGSVCSAYDARLRQ------KVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + +G G +GSV + L+Q KVAVK + S E +K H Sbjct: 42 KILGEGEFGSV---MEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHP 98 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSD--EHV------QFLVYQ 133 NV+ LL V +S + ++ + DL+ + L +H+ +F+V Sbjct: 99 NVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMV-D 157 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ---ADEEMTGYVA---TRW 187 + G++Y+ + +HRDL N + +D + + DFGL+++ D G +A +W Sbjct: 158 IALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKW 217 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAEL-LQGKALFPG 225 A E + + + Y D+W+ G M E+ +G +PG Sbjct: 218 I-AIESLADRV-YTSKSDVWAFGVTMWEIATRGMTPYPG 254 >5J0A-A nrPDB Length = 300 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 42/169 (24%), Positives = 78/169 (46%), Gaps = 18/169 (10%) Query: 63 IHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV--KCQ 120 ++ +R E ++LK L H N++G + T D S + LN+++ + + Sbjct: 56 VYQKRLMDEAKILKSLHHPNIVG----YRAFTEANDGSLCLAMEYGGEKSLNDLIEERYK 111 Query: 121 ALSDEHVQFLVYQ----LLRGLKYIH-SAGIIHRDLKPSNVAVNEDCE-LRILDFGLARQ 174 A D ++ + + RGLKY+H ++H D+K SNV + D E ++I D G++ Sbjct: 112 ASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLP 171 Query: 175 ADEEM------TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 DE M Y+ T ++ E + DI++ G + E++ Sbjct: 172 LDENMEVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMM 220 >3UIM-A nrPDB Length = 326 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 32/95 (33%), Positives = 52/95 (54%), Gaps = 8/95 (8%) Query: 136 RGLKYIHSA---GIIHRDLKPSNVAVNEDCELRILDFGLARQADEE----MTGYVATRWY 188 RGL Y+H IIHRD+K +N+ ++E+ E + DFGLA+ D + T T + Sbjct: 142 RGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGH 201 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALF 223 APE L+ ++ D++ G ++ EL+ G+ F Sbjct: 202 IAPEY-LSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >3G2F-A nrPDB Length = 336 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 64/236 (27%), Positives = 100/236 (42%), Gaps = 46/236 (19%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQK-VAVKKLSRPF-QSLIHARRTYRELRLLKHLKHE 81 L+ L +G G YG+V Y L ++ VAVK S Q+ I+ + YR + ++H+ Sbjct: 15 LKLLELIGRGRYGAV---YKGSLDERPVAVKVFSFANRQNFINEKNIYR----VPLMEHD 67 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQF-----LVYQLLR 136 N+ + V + + E LV N C+ LS + L + + R Sbjct: 68 NIARFI-VGDERVTADGRMEYLLVMEYYP----NGSLCKYLSLHTSDWVSSCRLAHSVTR 122 Query: 137 GLKYIHSA---------GIIHRDLKPSNVAVNEDCELRILDFGLAR-----------QAD 176 GL Y+H+ I HRDL NV V D I DFGL+ + D Sbjct: 123 GLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEED 182 Query: 177 EEMTGYVATRWYRAPEIMLNWMHYN------QTVDIWSVGCIMAEL-LQGKALFPG 225 V T Y APE++ ++ + VD++++G I E+ ++ LFPG Sbjct: 183 NAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPG 238 >4Y12-A nrPDB Length = 375 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 47/201 (23%), Positives = 90/201 (44%), Gaps = 17/201 (8%) Query: 73 RLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVY 132 + L + H +++ + + F T Y+V +G K Q L + Sbjct: 170 QFLAEVVHPSIVQIFN-FVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLL 228 Query: 133 QLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYV-ATRWYRAP 191 ++L L Y+HS G+++ DLKP N+ + E+ +L+++D G + + GY+ T ++AP Sbjct: 229 EILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINS--FGYLYGTPGFQAP 285 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 EI+ DI++VG +A L G Y+D G P + + K Sbjct: 286 EIVRTGP--TVATDIYTVGRTLAALTLDLPTRNGR-YVD---------GLPEDDPVLKTY 333 Query: 252 SEHARTYIQSLPPMPQKDLSS 272 + R +++ P P++ ++ Sbjct: 334 DSYGRLLRRAIDPDPRQRFTT 354 >2PZI-A nrPDB Length = 681 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 43/171 (25%), Positives = 79/171 (46%), Gaps = 16/171 (9%) Query: 103 YLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDC 162 Y+V +G K Q L + ++L L Y+HS G+++ DLKP N+ + E+ Sbjct: 160 YIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE- 218 Query: 163 ELRILDFGLARQADEEMTGYV-ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKA 221 +L+++D G + + GY+ T ++APEI+ DI++VG +A L Sbjct: 219 QLKLIDLGAVSRINS--FGYLYGTPGFQAPEIVRTGP--TVATDIYTVGRTLAALTLDLP 274 Query: 222 LFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSS 272 G Y+D G P + + K + R +++ P P++ ++ Sbjct: 275 TRNGR-YVD---------GLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFTT 315 >4F0G-A nrPDB Length = 287 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 48/213 (22%), Positives = 98/213 (46%), Gaps = 26/213 (12%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKL----SRPFQSLIHARRTY-RELRLLKHLKHEN 82 + +G G +G V + + VA+K L S +I + + RE+ ++ +L H N Sbjct: 25 KQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPN 84 Query: 83 VIGLLDVF-TPATSIEDF---SEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGL 138 ++ L + P + +F ++Y + VK + + D + G+ Sbjct: 85 IVKLYGLMHNPPRMVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLD---------IALGI 135 Query: 139 KYIHSAG--IIHRDLKPSNV---AVNEDCEL--RILDFGLARQADEEMTGYVATRWYRAP 191 +Y+ + I+HRDL+ N+ +++E+ + ++ DFGL++Q+ ++G + + AP Sbjct: 136 EYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVSGLLGNFQWMAP 195 Query: 192 E-IMLNWMHYNQTVDIWSVGCIMAELLQGKALF 223 E I Y + D +S I+ +L G+ F Sbjct: 196 ETIGAEEESYTEKADTYSFAMILYTILTGEGPF 228 >5TE0-A nrPDB Length = 347 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 46/170 (27%), Positives = 78/170 (45%), Gaps = 26/170 (15%) Query: 70 RELRLLKHLK-HENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHV 127 RE+++++ L H+N++G +D S D EV ++ G + N++ Q L Sbjct: 64 REIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMN-QRLQTGFT 122 Query: 128 QFLVYQLL----RGLKYIHSAG--IIHRDLKPSNVAVNEDCELRILDFGLARQ------- 174 + V Q+ + +H IIHRDLK N+ +++ + DFG A Sbjct: 123 ENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQT 182 Query: 175 -----ADEEMTGYVATRWYRAPEIMLNWMH---YNQTVDIWSVGCIMAEL 216 ++E+ Y T YRAPE M+N DIW++GC++ +L Sbjct: 183 EGVNAVEDEIKKY-TTLSYRAPE-MVNLYSGKIITTKADIWALGCLLYKL 230 >3I81-A nrPDB Length = 315 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 52/219 (23%), Positives = 99/219 (45%), Gaps = 25/219 (11%) Query: 18 WEVP-QRLQGLRPVGSGAYGSVCSAYDARL-----RQKVAVKKLSRPFQSLIHARRTYRE 71 WEV +++ R +G G++G V + +VA+K ++ S+ E Sbjct: 13 WEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEA-ASMRERIEFLNE 71 Query: 72 LRLLKHLKHENVIGLLDVFT---PATSIEDFS-----EVYLVTTLMGADLNNIVKCQALS 123 ++K +V+ LL V + P I + + YL + + N ++ +LS Sbjct: 72 ASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLS 131 Query: 124 DEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE----- 178 + +Q + ++ G+ Y+++ +HRDL N V ED ++I DFG+ R E Sbjct: 132 -KMIQ-MAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRK 189 Query: 179 -MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAEL 216 G + RW +PE + + + + D+WS G ++ E+ Sbjct: 190 GGKGLLPVRWM-SPESLKDGV-FTTYSDVWSFGVVLWEI 226 >6J5U-C nrPDB Length = 426 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 27/92 (29%), Positives = 49/92 (53%), Gaps = 8/92 (8%) Query: 136 RGLKYIHSAG--IIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATR-----WY 188 +GL ++H A +I+RD K +N+ ++ D ++ DFGLA+ +V+T+ Y Sbjct: 203 KGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGY 262 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQGK 220 APE + D++S G ++ EL+ G+ Sbjct: 263 AAPEYVATG-RLTAKSDVYSFGVVLLELISGR 293 >2CHL-A nrPDB Length = 351 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 53/229 (23%), Positives = 99/229 (43%), Gaps = 26/229 (11%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 + +G G +G + + + VA+K P +S A + + E R K L + I + Sbjct: 36 KKIGCGNFGELRLGKNLYTNEYVAIK--LEPMKS--RAPQLHLEYRFYKQLGSGDGIPQV 91 Query: 88 DVFTPATSIEDFSEVYLVTTLMGADLNNIVK-C-QALSDEHVQFLVYQLLRGLKYIHSAG 145 F P +V L+G L ++ C + S + V + QL+ ++Y+HS Sbjct: 92 YYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKN 146 Query: 146 IIHRDLKPSNVAVNEDCE-----LRILDFGLARQ-ADEEMTGYVATRWYRAPEIMLNWMH 199 +I+RD+KP N + + I+DF LA++ D E ++ R +++ +M Sbjct: 147 LIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMS 206 Query: 200 YNQTV--------DIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240 N + D+ ++G + L+G + G D LK + +G Sbjct: 207 INTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIG 254 >3MY0-A nrPDB Length = 305 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 56/209 (26%), Positives = 87/209 (41%), Gaps = 30/209 (14%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLS-RPFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 VG G YG V + VAVK S R QS Y + L +H+N++G Sbjct: 16 VGKGRYGEVWRGL--WHGESVAVKIFSSRDEQSWFRETEIYNTVLL----RHDNILGF-- 67 Query: 89 VFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH----- 142 + + TS ++++L+T L + ++ Q L L GL ++H Sbjct: 68 IASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFG 127 Query: 143 ---SAGIIHRDLKPSNVAVNEDCELRILDFGLA----RQADEEMTGY---VATRWYRAPE 192 I HRD K NV V + + I D GLA + +D G V T+ Y APE Sbjct: 128 TQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPE 187 Query: 193 IM-----LNWMHYNQTVDIWSVGCIMAEL 216 ++ + + DIW+ G ++ E+ Sbjct: 188 VLDEQIRTDCFESYKWTDIWAFGLVLWEI 216 >4L68-A nrPDB Length = 340 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 40/142 (28%), Positives = 67/142 (47%), Gaps = 18/142 (12%) Query: 136 RGLKYIHSAG---IIHRDLKPSNVAVNEDCELRILDFGLAR-------QADEEMTGYVAT 185 RGL ++H I+H+++ S + ++ED + RI+D GLAR MTG + Sbjct: 147 RGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGE 206 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQG-KAL----FPGS--DYIDQLKRIMEV 238 Y APE M + D++ +G ++ EL G KA+ F GS D++ QL+ + Sbjct: 207 FGYVAPEYSTT-MLASLKGDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRI 265 Query: 239 VGTPSPEVLAKISSEHARTYIQ 260 T + K E +++ Sbjct: 266 AETFDENIRGKGHDEEISKFVE 287 >5VC6-A nrPDB Length = 289 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 34/134 (25%), Positives = 61/134 (45%), Gaps = 1/134 (0%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL-KHENVIG 85 L +GSG +GSV A+K+ +P + + RE+ L +H +V+ Sbjct: 16 LEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVR 75 Query: 86 LLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAG 145 + + +E +L A N + ++ L+ Q+ RGL+YIHS Sbjct: 76 YFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMS 135 Query: 146 IIHRDLKPSNVAVN 159 ++H D+KPSN+ ++ Sbjct: 136 LVHMDIKPSNIFIS 149 >2CMW-A nrPDB Length = 310 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 63/256 (24%), Positives = 110/256 (42%), Gaps = 35/256 (13%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 + +G G +G + + + VA+K P +S A + + E R K L GL Sbjct: 6 KKIGCGNFGELRLGKNLYTNEYVAIK--LEPIKS--RAPQLHLEYRFYKQLGSAGE-GLP 60 Query: 88 DV--FTPATSIEDFSEVYLVTTLMGADLNNIVK-C-QALSDEHVQFLVYQLLRGLKYIHS 143 V F P +V L+G L ++ C + + + V + QLL ++Y+HS Sbjct: 61 QVYYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHS 115 Query: 144 AGIIHRDLKPSNVAVNEDCE-----LRILDFGLARQ-ADEEMTGYVATRWYRAPEIMLNW 197 +I+RD+KP N + + I+DFGLA++ D E ++ R +++ + Sbjct: 116 KNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 175 Query: 198 MHYNQTV--------DIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG-----TPSP 244 M N + D+ ++G + L+G + G D LK + +G TP Sbjct: 176 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDTKRNTPI- 233 Query: 245 EVLAKISSEHARTYIQ 260 E L + E TY++ Sbjct: 234 EALCENFPEEMATYLR 249 >4H1J-A nrPDB Length = 293 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 48/205 (23%), Positives = 94/205 (45%), Gaps = 16/205 (7%) Query: 28 RPVGSGAYGSVC-SAYDARLRQKVAVK-KLSRPFQSLIHARRTYRELRLLKHLKHENVIG 85 R +G G +G V Y +K+ V K + +L + + E ++K+L H +++ Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVK 89 Query: 86 LLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVY--QLLRGLKYIHS 143 L+ + IE+ ++ +L + ++ S + + ++Y Q+ + + Y+ S Sbjct: 90 LIGI------IEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLES 143 Query: 144 AGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRW---YRAPEIMLNWMH 199 +HRD+ N+ V +++ DFGL+R DE+ TR + +PE +N+ Sbjct: 144 INCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPE-SINFRR 202 Query: 200 YNQTVDIWSVGCIMAELLQ-GKALF 223 + D+W M E+L GK F Sbjct: 203 FTTASDVWMFAVCMWEILSFGKQPF 227 >1PY5-A nrPDB Length = 326 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 98/213 (46%), Gaps = 38/213 (17%) Query: 30 VGSGAYGSVCSAYDARLR-QKVAVKKLSRPFQSLIHARRTYRELRLLKH--LKHENVIGL 86 +G G +G V + + R ++VAVK S + R +RE + + L+HEN++G Sbjct: 37 IGKGRFGEV---WRGKWRGEEVAVKIFSSREE-----RSWFREAEIYQTVMLRHENILG- 87 Query: 87 LDVFTPATSIED--FSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH- 142 F A + ++ +++++LV+ L + + ++ E + L GL ++H Sbjct: 88 ---FIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHM 144 Query: 143 -------SAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM-------TGYVATRWY 188 I HRDLK N+ V ++ I D GLA + D V T+ Y Sbjct: 145 EIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRY 204 Query: 189 RAPEIM---LNWMHYN--QTVDIWSVGCIMAEL 216 APE++ +N H+ + DI+++G + E+ Sbjct: 205 MAPEVLDDSINMKHFESFKRADIYAMGLVFWEI 237 >5AR8-A nrPDB Length = 326 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 42/160 (26%), Positives = 75/160 (46%), Gaps = 14/160 (8%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR-TYRELRLLKHLKH 80 +L LR + GA G+V SA A R +VAVK L L R+ RE +L + Sbjct: 32 HKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARF 91 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLR--- 136 ++ +L + + +VT M LN ++ + + L +++L Sbjct: 92 SYILPILGICNEPEFLG------IVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIA 145 Query: 137 -GLKYIHSAG--IIHRDLKPSNVAVNEDCELRILDFGLAR 173 G+ Y+H+ ++H DLK N+ ++ + ++I DFGL++ Sbjct: 146 LGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSK 185 >4M69-B nrPDB Length = 283 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 51/229 (22%), Positives = 103/229 (44%), Gaps = 29/229 (12%) Query: 47 RQKVAVKKLSRP-FQSLIHARRTYR-ELRLLKHLKHENVIGLLDVFTPATS-------IE 97 R V +K + P +S+ R T+ E++ +K N++ + + T + Sbjct: 32 RSPVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVM 91 Query: 98 DFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVA 157 ++ E+ + L+ + + + ++L LV + RGL +H + +HR++ S+ Sbjct: 92 EYCELGTLRELLDREKDLTMSVRSL-------LVLRAARGLYRLHHSETLHRNISSSSFL 144 Query: 158 VNEDCELRILDF-------GLARQADEEMTGYVATRWYRAPEIMLN-WMHYNQTVDIWSV 209 V ++++ F ++R A ++ Y +PE + N + Y+ +I+S Sbjct: 145 VAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSF 204 Query: 210 GCIMAELLQGKALFPGSDY--IDQL---KRIMEVVGTPSPEVLAKISSE 253 G ++ E+ GK F G D I +L + E VG PE+L +I +E Sbjct: 205 GIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINE 253 >4JRN-A nrPDB Length = 372 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 50/227 (22%), Positives = 81/227 (35%), Gaps = 52/227 (22%) Query: 29 PVGSGAYGSVCSAYDARLRQKVAVKKL-------SRPFQSLIHARRTYRELRLLKHLKH- 80 P+GSG + +V A D +++AVK L YR L K K Sbjct: 75 PLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDA 134 Query: 81 ----------------------ENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK 118 E VIGL + P +L+ AD++ ++ Sbjct: 135 QESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVP--------NYFLLMMRAEADMSKVIS 186 Query: 119 CQALSDEHVQ----------FLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILD 168 D V +L Q ++ + + + GI+H D+KP+N + +D L + D Sbjct: 187 -WVFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGD 245 Query: 169 FGLARQADEEMTGYVATRWYRAPE--IMLNWMHYNQTVDIWSVGCIM 213 FG R + + + T Y PE + Y D W +G + Sbjct: 246 FGTYR-INNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITL 291 >4NT4-A nrPDB Length = 312 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 61/255 (23%), Positives = 109/255 (42%), Gaps = 28/255 (10%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLI-HARRTYRELRLLKHLKHENVIGL 86 + +G G +G + + + VA+K P +S YR +LL G+ Sbjct: 18 KKIGCGNFGELRLGKNLYNNEHVAIK--MEPMKSKAPQLHLEYRFYKLLGSHADNAPDGI 75 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA--LSDEHVQFLVYQLLRGLKYIHSA 144 ++ T ++ +V L+G L ++ A S + V + QLL ++Y+HS Sbjct: 76 PRIYHLGTCGGRYNA--MVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVHSR 133 Query: 145 GIIHRDLKPSNVAVNEDCELR-----ILDFGLARQ-ADEEMTGYVATRWYRAPEIMLNWM 198 +I+RD+KP N + R I+DFGLA++ D + ++ R +++ +M Sbjct: 134 HLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYM 193 Query: 199 HYNQTV--------DIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG-----TPSPE 245 N + D+ ++G + L+G + G D LK + +G TP E Sbjct: 194 SINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDTKRATPI-E 251 Query: 246 VLAKISSEHARTYIQ 260 VL E TY++ Sbjct: 252 VLCDGHPEEFATYLR 266 >3LMG-A nrPDB Length = 344 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 47/210 (22%), Positives = 99/210 (47%), Gaps = 29/210 (13%) Query: 24 LQGLRPVGSGAYGSVCSAY----DARLRQKVAVKKLS-----RPFQSLIHARRTYRELRL 74 L+ L+ +GSG +G+V ++ V +K + + FQ++ + Sbjct: 33 LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTD------HMLA 86 Query: 75 LKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ-ALSDEHVQFLVYQ 133 + L H +++ LL P +S++ ++ YL +G+ L+++ + + AL + + Q Sbjct: 87 IGSLDHAHIVRLLG-LCPGSSLQLVTQ-YLP---LGSLLDHVRQHRGALGPQLLLNWGVQ 141 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR--QADEEMTGY----VATRW 187 + +G+ Y+ G++HR+L NV + ++++ DFG+A D++ Y +W Sbjct: 142 IAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKW 201 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 I ++ Y D+WS G + EL+ Sbjct: 202 MALESI--HFGKYTHQSDVWSYGVTVWELM 229 >5CEK-A nrPDB Length = 263 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 38/155 (24%), Positives = 71/155 (45%), Gaps = 13/155 (8%) Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-LSDEHVQFLVYQLLRGL 138 H N+ G+++V T F E D+++ V+ + L +E L Q++ + Sbjct: 60 HSNITGIVEVILGETKAYVFFEKDF------GDMHSYVRSRKRLREEEAARLFKQIVSAV 113 Query: 139 KYIHSAGIIHRDLKPSNV--AVNEDCELRIL---DFGLARQADEEMTGYVATRWYRAPEI 193 + H + I+ DLK + E +LR+ D + + D+ ++ Y +PEI Sbjct: 114 AHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEI 173 Query: 194 MLNWMHYN-QTVDIWSVGCIMAELLQGKALFPGSD 227 + Y+ + D+WS+G ++ LL G+ F SD Sbjct: 174 LNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSD 208 >3ZBF-A nrPDB Length = 322 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 58/233 (24%), Positives = 100/233 (42%), Gaps = 36/233 (15%) Query: 30 VGSGAYGSVCSAYDARL------RQKVAVKKLSRPFQSLIHARRTY-RELRLLKHLKHEN 82 +GSGA+G V + KVAVK L + S + + +E L+ H N Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKK--GSTDQEKIEFLKEAHLMSKFNHPN 98 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEH--------VQFLVYQL 134 ++ L V + + + ++ + G DL ++ ++ + + L + Sbjct: 99 ILKQLGV-----CLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDI 153 Query: 135 LRGLKYIHSAGIIHRDLKPSN--VAVNEDCELRIL---DFGLARQA------DEEMTGYV 183 +G Y+ IHRDL N V+V + RI+ DFGLAR + G + Sbjct: 154 SKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLL 213 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRI 235 RW APE +++ + Q+ D+WS G ++ E+L G +P +D L + Sbjct: 214 PVRWM-APESLMDGIFTTQS-DVWSFGILIWEILTLGHQPYPAHSNLDVLNYV 264 >4BTF-A nrPDB Length = 469 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 52/233 (22%), Positives = 103/233 (44%), Gaps = 37/233 (15%) Query: 47 RQKVAVKKLSRP-FQSLIHARRTYR-ELRLLKHLKHENVIGLLDVFTPATS-------IE 97 R V +K + P +S+ R T+ E++ +K N++ + + T + Sbjct: 218 RSPVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVM 277 Query: 98 DFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVA 157 ++ E+ + L+ + + + ++L LV + RGL +H + +HR++ S+ Sbjct: 278 EYCELGTLRELLDREKDLTMSVRSL-------LVLRAARGLYRLHHSETLHRNISSSSFL 330 Query: 158 VNEDCELRILDFGL-------ARQADEEMTGYVATRWYRAPEIMLN-WMHYNQTVDIWSV 209 V ++++ F L +R A ++ Y +PE + N + Y+ +I+S Sbjct: 331 VAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSF 390 Query: 210 GCIMAELLQGKALFPGSDYIDQLKRIMEV---------VGTPSPEVLAKISSE 253 G ++ E+ GK F G D K+I E+ VG PE+L +I +E Sbjct: 391 GIVLWEIATGKIPFEGCDS----KKIRELVAEDKKQEPVGQDCPELLREIINE 439 >6DC0-A nrPDB Length = 292 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 38/155 (24%), Positives = 71/155 (45%), Gaps = 13/155 (8%) Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-LSDEHVQFLVYQLLRGL 138 H N+ G+++V T F E D+++ V+ + L +E L Q++ + Sbjct: 57 HSNITGIVEVILGETKAYVFFEKDF------GDMHSYVRSRKRLREEEAARLFKQIVSAV 110 Query: 139 KYIHSAGIIHRDLKPSNV--AVNEDCELRIL---DFGLARQADEEMTGYVATRWYRAPEI 193 + H + I+ DLK + E +LR+ D + + D+ ++ Y +PEI Sbjct: 111 AHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEI 170 Query: 194 MLNWMHYN-QTVDIWSVGCIMAELLQGKALFPGSD 227 + Y+ + D+WS+G ++ LL G+ F SD Sbjct: 171 LNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSD 205 >4TN6-A nrPDB Length = 318 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 44/170 (25%), Positives = 79/170 (46%), Gaps = 22/170 (12%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVK----KLSRPFQSLIHARRTYRELRLL 75 V R + R +GSG++G + D ++VA+K K P + + E ++ Sbjct: 5 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHP--------QLHIESKIY 56 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK-C-QALSDEHVQFLVYQ 133 K ++ G + + T + +V L+G L ++ C + S + V L Q Sbjct: 57 KMMQ-----GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQ 111 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVN---EDCELRILDFGLARQADEEMT 180 ++ ++YIHS IHRD+KP N + + + I+DFGLA++ + T Sbjct: 112 MISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDART 161 >1U54-B nrPDB Length = 291 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 63/226 (27%), Positives = 92/226 (40%), Gaps = 35/226 (15%) Query: 11 QELNKTVWEVPQRLQGLRPVGSGAYGSVCSA-YDARLRQ--KVAVKKLSRPFQSLIHARR 67 Q L + E RL L +G G++G V +DA + VAVK L S A Sbjct: 9 QSLTCLIGEKDLRL--LEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMD 66 Query: 68 TY-RELRLLKHLKHENVIGLLDV-FTPATSIEDFSEVYLVTTL--MGADLNNIVKCQALS 123 + RE+ + L H N+I L V TP + +VT L +G+ L+ + K Q Sbjct: 67 DFIREVNAMHSLDHRNLIRLYGVVLTPP--------MKMVTELAPLGSLLDRLRKHQG-- 116 Query: 124 DEHVQFLVYQLLR-------GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD 176 FL+ L R G+ Y+ S IHRDL N+ + ++I DFGL R Sbjct: 117 ----HFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALP 172 Query: 177 EEMTGYVATRWYRAPEIM-----LNWMHYNQTVDIWSVGCIMAELL 217 + YV + P L ++ D W G + E+ Sbjct: 173 QNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMF 218 >5WNL-A nrPDB Length = 342 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 35/126 (27%), Positives = 63/126 (50%), Gaps = 11/126 (8%) Query: 130 LVYQLLRGLKYIH--SAGIIHRDLKPSNVAVNEDCELRILDFGLAR------QADEEMTG 181 +V++ G+ ++H S ++H +LKP+N+ ++ ++I DFGLA+ D M G Sbjct: 121 IVHETAVGMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDG 180 Query: 182 YVATRWYRAPE-IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240 T Y PE I ++ D++S ++ +L K P +D + L +M+VV Sbjct: 181 LFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKK--PFADEKNILHIMMKVVK 238 Query: 241 TPSPEV 246 PE+ Sbjct: 239 GHRPEL 244 >4HZS-A nrPDB Length = 341 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 88/213 (41%), Gaps = 33/213 (15%) Query: 24 LQGLRPVGSGAYGSVCSA-YDARLRQ--KVAVKKLSRPFQSLIHARRTY-RELRLLKHLK 79 L+ L +G G++G V +DA + VAVK L S A + RE+ + L Sbjct: 14 LRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLD 73 Query: 80 HENVIGLLDV-FTPATSIEDFSEVYLVTTL--MGADLNNIVKCQALSDEHVQFLVYQLLR 136 H N+I L V TP + +VT L +G+ L+ + K Q FL+ L R Sbjct: 74 HRNLIRLYGVVLTPP--------MKMVTELAPLGSLLDRLRKHQG------HFLLGTLSR 119 Query: 137 -------GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYR 189 G+ Y+ S IHRDL N+ + ++I DFGL R + YV + Sbjct: 120 YAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRK 179 Query: 190 APEIM-----LNWMHYNQTVDIWSVGCIMAELL 217 P L ++ D W G + E+ Sbjct: 180 VPFAWCAPESLKTRTFSHASDTWMFGVTLWEMF 212 >4IX6-A nrPDB Length = 350 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 54/206 (26%), Positives = 82/206 (39%), Gaps = 48/206 (23%) Query: 133 QLLRGLKYIHSAGIIHRDLKPSN-VAVNEDCE-LRILDFGLARQA---DEEMTGYVAT-- 185 +LL L +H G++HRD+KP+N +A +D L+++D G A E + Y Sbjct: 151 ELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETLNYYPGDGP 210 Query: 186 ---RWYRAPEIML---------------NW-MHYNQTVDIWSVGCIMAELLQGKALFPGS 226 R+ +A E+ L W H D WS GC+M +L G Sbjct: 211 ADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQL-----AVVGL 265 Query: 227 DYIDQLKRIM---EVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLA-I 282 L+R + + VG + S E+ +L AN A Sbjct: 266 RTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALD-------------ANGGAGW 312 Query: 283 DLLGRMLVLDSDQRVSAAEALAHAYF 308 DL R++ + D R S AL+HA+F Sbjct: 313 DLCQRLMEAERDARASCEAALSHAFF 338 >4XHH-A nrPDB Length = 403 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 40/160 (25%), Positives = 75/160 (46%), Gaps = 14/160 (8%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 V ++ + R +GSG++G + + ++VA++ S + H + Y E R+ K+L Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSR---HPQLDY-ESRVYKYLS 60 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK-C-QALSDEHVQFLVYQLLRG 137 I + F +V L+G L ++ C + S + V L Q++ Sbjct: 61 GGVGIPFIRWFGREGEYNA-----MVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICR 115 Query: 138 LKYIHSAGIIHRDLKPSNVAVN---EDCELRILDFGLARQ 174 ++YIH IHRD+KP N + + ++DFGL+++ Sbjct: 116 VQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKK 155 >4XHL-A nrPDB Length = 394 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 39/160 (24%), Positives = 74/160 (46%), Gaps = 14/160 (8%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 V ++ + R +GSG++G + + ++VA++ S + H + Y E R+ ++L Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSR---HPQLDY-ESRVYRYLS 60 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK-C-QALSDEHVQFLVYQLLRG 137 I + F +V L+G L ++ C + S + V L Q+ Sbjct: 61 GGVGIPFIRWFGREGEYNA-----MVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCR 115 Query: 138 LKYIHSAGIIHRDLKPSNVAVN---EDCELRILDFGLARQ 174 ++YIH IHRD+KP N + + ++DFGL+++ Sbjct: 116 IQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKK 155 >6BFN-A nrPDB Length = 342 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 53/219 (24%), Positives = 89/219 (40%), Gaps = 43/219 (19%) Query: 30 VGSGAYGSVCSAYDARLRQKV-AVKKL--SRPFQSLIHARRTYRELRLLKHLKHENVI-- 84 +G G +G V Y A +R V AVK+L + + + E+ L +H N++ Sbjct: 30 IGEGGFGCV---YRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 85 ----------GLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQL 134 L+ F P S+ED ++ T C LS ++ Sbjct: 87 AGYCAQNGFYCLVYGFLPNGSLED--RLHCQTQ----------ACPPLSWPQRLDILLGT 134 Query: 135 LRGLKYIH--SAGIIHRDLKPSNVAVNEDCELRILDFGLAR------QADEEMTGYVATR 186 R ++++H S +IH D+K SNV ++E ++ DFGLAR + + + T+ Sbjct: 135 ARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQ 194 Query: 187 WYRA-----PEIMLNWMHYNQTVDIWSVGCIMAELLQGK 220 R PE + D +S G ++ E L G+ Sbjct: 195 TVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >1CSN-A nrPDB Length = 298 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 38/153 (24%), Positives = 68/153 (44%), Gaps = 16/153 (10%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 R +G G++G + + Q+VA+K R R YR +LL G+ Sbjct: 16 RRIGEGSFGVIFEGTNLLNNQQVAIKFEPRR-SDAPQLRDEYRTYKLL-----AGCTGIP 69 Query: 88 DVFTPATSIEDFSEVYLVTTLMGADLNNIVK-C-QALSDEHVQFLVYQLLRGLKYIHSAG 145 +V+ E V LV L+G L +++ C + S + V Q+L ++ IH Sbjct: 70 NVYYFGQ--EGLHNV-LVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKS 126 Query: 146 IIHRDLKPSNVAVNEDCE-----LRILDFGLAR 173 +++RD+KP N + + ++DFG+ + Sbjct: 127 LVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVK 159 >2RSV-A nrPDB Length = 403 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 23/74 (31%), Positives = 41/74 (55%), Gaps = 4/74 (5%) Query: 103 YLVTTLMGADLNNIVKCQA--LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNE 160 +++ G+DL I + A S + V L ++L L+YIH +H D+K SN+ +N Sbjct: 135 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 194 Query: 161 DC--ELRILDFGLA 172 ++ ++D+GLA Sbjct: 195 KNPDQVYLVDYGLA 208 >5M07-A nrPDB Length = 276 Score = 37.4 bits (85), Expect = 0.011, Method: Compositional matrix adjust. Identities = 17/49 (34%), Positives = 27/49 (55%), Gaps = 4/49 (8%) Query: 130 LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNE----DCELRILDFGLARQ 174 +V + L Y H G++HRD+ P+NV + D + + DFG+A Q Sbjct: 137 IVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ 185 >2LAV-A nrPDB Length = 361 Score = 37.0 bits (84), Expect = 0.013, Method: Compositional matrix adjust. Identities = 23/74 (31%), Positives = 41/74 (55%), Gaps = 4/74 (5%) Query: 103 YLVTTLMGADLNNIVKCQA--LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNE 160 +++ G+DL I + A S + V L ++L L+YIH +H D+K SN+ +N Sbjct: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 Query: 161 DC--ELRILDFGLA 172 ++ ++D+GLA Sbjct: 188 KNPDQVYLVDYGLA 201 >5VDK-A nrPDB Length = 297 Score = 35.8 bits (81), Expect = 0.030, Method: Compositional matrix adjust. Identities = 32/136 (23%), Positives = 61/136 (44%), Gaps = 7/136 (5%) Query: 27 LRPVGSGAYGSVCSAYDARLRQKV-AVKKLSRPFQSLIHARRTYREL---RLLKHLKHEN 82 + +G G +G+V RL V A+K+ + F L + E+ +L H H + Sbjct: 20 VEKIGVGEFGTVYKCIK-RLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGH--HPH 76 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 V+ + + +E +L A N + ++ ++ Q+ GL YIH Sbjct: 77 VVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIH 136 Query: 143 SAGIIHRDLKPSNVAV 158 ++ ++H D+KPSN+ + Sbjct: 137 NSSMVHLDIKPSNIFI 152 >6G4J-A nrPDB Length = 315 Score = 35.4 bits (80), Expect = 0.041, Method: Compositional matrix adjust. Identities = 31/119 (26%), Positives = 50/119 (42%), Gaps = 5/119 (4%) Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNE-DCELRILDFGLARQADEEMTGYV 183 E + L+ QLL L +H G I DLKP N+ V +R +D G + + Y Sbjct: 123 EWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEY- 181 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTP 242 T +Y + D+++V IM + K + +QL+ ++E G P Sbjct: 182 -TEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSLIE--GNP 237 >5X18-A nrPDB Length = 295 Score = 34.7 bits (78), Expect = 0.062, Method: Compositional matrix adjust. Identities = 21/78 (26%), Positives = 43/78 (55%), Gaps = 7/78 (8%) Query: 104 LVTTLMGADLNNIVK-C-QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-- 159 LV L+G L ++ C + S + V + Q++ ++ +H+ +I+RD+KP N + Sbjct: 80 LVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRP 139 Query: 160 ---EDCELRILDFGLARQ 174 + + ++DFG+A+Q Sbjct: 140 GQPDANNIHLIDFGMAKQ 157 >5UU1-A nrPDB Length = 324 Score = 34.7 bits (78), Expect = 0.072, Method: Compositional matrix adjust. Identities = 40/159 (25%), Positives = 74/159 (46%), Gaps = 15/159 (9%) Query: 28 RPVGSGAYGSVCSAY-------DARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL-- 78 + +GSG +G + A+ DAR KV ++ F L +R ++ + K + Sbjct: 22 KKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIER 81 Query: 79 KHENVIGL-LDVFTPATSIEDFSEVYLVTTLMGADLNNIV-KCQALSDEHVQFLVYQLLR 136 K + +G+ L + T + S ++V +G DL I + V L ++L Sbjct: 82 KQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLD 141 Query: 137 GLKYIHSAGIIHRDLKPSNVAV---NEDCELRILDFGLA 172 L+YIH +H D+K +N+ + N D ++ + D+GL+ Sbjct: 142 VLEYIHENEYVHGDIKAANLLLGYKNPD-QVYLADYGLS 179 >6EQI-C nrPDB Length = 433 Score = 34.7 bits (78), Expect = 0.074, Method: Compositional matrix adjust. Identities = 28/105 (26%), Positives = 45/105 (42%), Gaps = 27/105 (25%) Query: 137 GLKYIHSAGIIHRDLKPSNVAVNED-----CELRILDFGLA------------RQADEEM 179 + +++ I HRDLK N+ V+ + I DFG R D++ Sbjct: 179 AVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDK 238 Query: 180 TGYVATRWYRAPEI------MLNWMHYNQTVDIWSVGCIMAELLQ 218 G R APEI +W++Y ++ D+W+VG I E+ Sbjct: 239 GG---NRALMAPEIANAKPGTFSWLNYKKS-DLWAVGAIAYEIFN 279 >4AZV-A nrPDB Length = 569 Score = 34.3 bits (77), Expect = 0.080, Method: Compositional matrix adjust. Identities = 15/37 (40%), Positives = 21/37 (56%) Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFG 170 LLR L + G H D++P NV V+ R++DFG Sbjct: 348 LLRSLAALEKQGFWHDDVRPWNVMVDARQHARLIDFG 384 >4AZW-A nrPDB Length = 471 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 15/37 (40%), Positives = 21/37 (56%) Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFG 170 LLR L + G H D++P NV V+ R++DFG Sbjct: 348 LLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDFG 384 >5OAT-A nrPDB Length = 411 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 49/182 (26%), Positives = 80/182 (43%), Gaps = 35/182 (19%) Query: 76 KHLK-HENVIGLLDVFT------------PATSIEDFSEVYLVTTLMGADLNNIVKCQAL 122 KHL H N++ + VFT P + S ++L+ +L + + A Sbjct: 93 KHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMS-LFLLMKRYDCNLQSFLS-TAP 150 Query: 123 SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN----EDCELRILDFG--LARQAD 176 S L+ QLL G+ ++ + GI HRDLK N+ ++ E L I DFG LA + + Sbjct: 151 STRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTN 210 Query: 177 EEMTGYVATRWYR-------APEIM------LNWMHYNQTVDIWSVGCIMAELLQGKALF 223 Y + + APEI+ + ++Y++ D+W+VG I E+ F Sbjct: 211 GLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYSK-ADLWAVGAIAYEIFNCHNPF 269 Query: 224 PG 225 G Sbjct: 270 YG 271 >6EWX-A nrPDB Length = 484 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 15/33 (45%), Positives = 21/33 (63%) Query: 124 DEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNV 156 + V FL+ QL GL+++ GIIHRDL N+ Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENL 241 >5VE6-A nrPDB Length = 492 Score = 33.5 bits (75), Expect = 0.14, Method: Compositional matrix adjust. Identities = 15/33 (45%), Positives = 21/33 (63%) Query: 124 DEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNV 156 + V FL+ QL GL+++ GIIHRDL N+ Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENL 239 >3ENH-A nrPDB Length = 540 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 41/181 (22%), Positives = 72/181 (39%), Gaps = 32/181 (17%) Query: 9 YRQELNKTVW---------EVPQRLQGLRPVGSGAYGSVCSA----YDARLRQKVAVKKL 55 YR ++ + W ++P+ L +G GA + +D ++++V Sbjct: 319 YRTDMVEVNWIKEIKGKKRKIPEHL-----IGKGAEADIKRDSYLDFDVIIKERVKKGYR 373 Query: 56 SRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNN 115 I RT RE R L +K D PA I D +M + +N Sbjct: 374 DERLDENIRKSRTAREARYLALVK--------DFGIPAPYIFDVD--LDNKRIMMSYING 423 Query: 116 IVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA 175 + + D + Y++ + +H +IH DL SN ++D L I+DFGL + + Sbjct: 424 KLAKDVIEDN--LDIAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGKIS 479 Query: 176 D 176 + Sbjct: 480 N 480 >4G7X-B nrPDB Length = 138 Score = 32.7 bits (73), Expect = 0.22, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 22/36 (61%) Query: 284 LLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPE 319 LLG + VLD D R+ AA A A + + P+D+P+ Sbjct: 88 LLGSLTVLDGDSRLCAATKRAVAQVNSFPLPKDQPD 123 >6FW4-A nrPDB Length = 101 Score = 32.0 bits (71), Expect = 0.41, Method: Composition-based stats. Identities = 15/36 (41%), Positives = 22/36 (61%) Query: 284 LLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPE 319 LLG + VLD D R+ AA A A + + P+D+P+ Sbjct: 51 LLGSLTVLDGDSRLCAATKRAVAQVNSFPLPKDQPD 86 >2E5M-A nrPDB Length = 409 Score = 31.2 bits (69), Expect = 0.68, Method: Compositional matrix adjust. Identities = 19/61 (31%), Positives = 31/61 (50%), Gaps = 10/61 (16%) Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMA----ELLQGKALFPG------SDYIDQLKRIMEV 238 +A E+ML WM +N+ D+ MA ++ Q A F G +Y D+L +IM+ Sbjct: 349 KAGELMLRWMGWNEAADLIEKAINMAIRDKKVTQDIARFMGVKALGTKEYADELIKIMDT 408 Query: 239 V 239 + Sbjct: 409 I 409 >6M7Z-A nrPDB Length = 319 Score = 31.2 bits (69), Expect = 0.78, Method: Compositional matrix adjust. Identities = 25/105 (23%), Positives = 46/105 (43%), Gaps = 9/105 (8%) Query: 123 SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY 182 S VQ L ++ LK +H+ G++HR ++ ++ +V D + + A E + Sbjct: 142 SHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDGTVVLGGLDTAAPIGTETRLW 201 Query: 183 VATRWYR-APEIMLNWM--------HYNQTVDIWSVGCIMAELLQ 218 V APEI N++ + D++S+G L+Q Sbjct: 202 VGFFGQETAPEIDRNFLADLALTQGRHTVKSDVYSLGVAFRNLVQ 246 >4O1O-A nrPDB Length = 717 Score = 31.2 bits (69), Expect = 0.81, Method: Compositional matrix adjust. Identities = 12/46 (26%), Positives = 25/46 (54%) Query: 124 DEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDF 169 DE + ++ L + + +H +G H+DL+P N+ ++ + DF Sbjct: 441 DESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADF 486 >5DMZ-A nrPDB Length = 365 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 40/161 (24%), Positives = 67/161 (41%), Gaps = 29/161 (18%) Query: 30 VGSGAYGSVCSAY-----DARLRQKVAVK--KLSRPFQSLIHARRTYRELRLLKHLKHEN 82 +G GA+ V A DA+ +QK +K K + P++ I + R ++H+ + Sbjct: 73 LGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMFMK- 131 Query: 83 VIGLLDVFTPATSIEDFS----EVYLVTTLMGA-DLNNIVKCQALSDEHVQFLVYQLLRG 137 F A ++ S E+Y TL+ A +L + + V ++L Sbjct: 132 -------FYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYM 184 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE 178 ++ +H IIH D+KP N IL G Q DE+ Sbjct: 185 IEQVHDCEIIHGDIKPDNF---------ILGNGFLEQDDED 216 >5UV4-A nrPDB Length = 311 Score = 29.6 bits (65), Expect = 2.2, Method: Compositional matrix adjust. Identities = 48/206 (23%), Positives = 83/206 (40%), Gaps = 23/206 (11%) Query: 30 VGSGAYGSVCSAYDARLRQK--VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 +G +G+ +Y A L + VK L F + RE++ L ++H N++ L Sbjct: 33 IGRSCHGT---SYKATLDNGYMLTVKWLKEGFAK--SKKEFSREIKKLGSVRHPNLVPLR 87 Query: 88 DVF-----TPATSIEDFSEVYLVTTLMGA-DLNNIVKCQALSDEHVQFLVYQLLRGLKYI 141 + I D+++ ++T + D N+ LS + + R L Y+ Sbjct: 88 GYYWGPKEHERIMISDYADATSLSTYLSEFDERNL---PPLSAGQRLNIAIDIARCLDYL 144 Query: 142 HSAGII-HRDLKPSNVAV-NEDCELRILDFGLARQAD----EEMTGYVATRWYRAPEIML 195 H+ +I H ++K SNV + N + D+ L R E Y PE Sbjct: 145 HNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSS 204 Query: 196 NWMHY-NQTVDIWSVGCIMAELLQGK 220 + D+++ G I+ ELL GK Sbjct: 205 TSKPCPSLKSDVYAFGVILLELLTGK 230 >5XYI-G nrPDB Length = 216 Score = 28.9 bits (63), Expect = 3.6, Method: Compositional matrix adjust. Identities = 23/66 (34%), Positives = 34/66 (51%), Gaps = 8/66 (12%) Query: 21 PQRLQGLRPVGSGAYGSVCSAYDAR---LRQKVAVKKLSRP-FQSLIHARRTYRELRLLK 76 P+R LR + +G S +DA L+++V K + P Q LI ARR R+ R+LK Sbjct: 135 PKRASTLRAM----FGITDSKFDASKLVLKREVKPGKFTSPKVQRLITARRVARKNRMLK 190 Query: 77 HLKHEN 82 K + Sbjct: 191 ERKEKR 196 >6CHJ-A nrPDB Length = 455 Score = 28.9 bits (63), Expect = 4.1, Method: Compositional matrix adjust. Identities = 13/64 (20%), Positives = 32/64 (50%), Gaps = 1/64 (1%) Query: 211 CIMAELLQGKALFPGSDY-IDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKD 269 C++ + + G F + + +++ + E GT +V+ + + RTY+ + +P+K Sbjct: 229 CMLNQKITGSRRFAAQSWCLKRIRAVCEAYGTTVNDVVTAMCAAALRTYLMNQDALPEKP 288 Query: 270 LSSI 273 L + Sbjct: 289 LVAF 292 >6J6I-B nrPDB Length = 351 Score = 28.5 bits (62), Expect = 4.4, Method: Compositional matrix adjust. Identities = 25/104 (24%), Positives = 48/104 (46%), Gaps = 10/104 (9%) Query: 133 QLLRGLKYIHSAG---IIHRDLKPSNVAVNEDCELRILDFGLARQADE-----EMTGYVA 184 ++ + Y+H+A IIHRD+KP +V ++++ ++ D + E E + Sbjct: 171 EIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLG 230 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGK-ALFPGSD 227 T Y P + + D++S G + ++ GK A+ SD Sbjct: 231 TFGYIDP-LYHKTCFVTEYTDVYSFGICLLVIITGKPAIMTISD 273 >5H6O-A nrPDB Length = 317 Score = 28.5 bits (62), Expect = 4.5, Method: Compositional matrix adjust. Identities = 17/46 (36%), Positives = 21/46 (45%) Query: 6 AGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVA 51 AG R EL + + Q L VG GA G C D R+R +A Sbjct: 178 AGLKRLELESRIRSFIEPEQSLPAVGQGAVGIECRVNDQRVRALLA 223 >4OAU-C nrPDB Length = 699 Score = 28.5 bits (62), Expect = 5.4, Method: Compositional matrix adjust. Identities = 12/47 (25%), Positives = 26/47 (55%), Gaps = 1/47 (2%) Query: 124 DEHVQFLVYQLLRGLKYIH-SAGIIHRDLKPSNVAVNEDCELRILDF 169 DE + ++ + + ++ +H S G H+DL+P N+ ++ + DF Sbjct: 438 DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 484 >4BWP-A nrPDB Length = 448 Score = 28.1 bits (61), Expect = 6.0, Method: Compositional matrix adjust. Identities = 12/29 (41%), Positives = 18/29 (62%) Query: 130 LVYQLLRGLKYIHSAGIIHRDLKPSNVAV 158 ++ QL GLK IH AG+ + L P+ + V Sbjct: 186 IIMQLTAGLKAIHHAGLACKVLDPTKIIV 214 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3GC9-A nrPDB 544 e-155 4EWQ-A nrPDB 487 e-138 3OHT-A nrPDB 479 e-135 1CM8-A nrPDB 451 e-127 4MYG-A nrPDB 428 e-120 5AWM-A nrPDB 386 e-108 4QTB-A nrPDB 379 e-106 4IC8-A nrPDB 379 e-105 6DTL-A nrPDB 377 e-105 2XS0-A nrPDB 377 e-105 5NGU-A nrPDB 377 e-105 1JNK-A nrPDB 376 e-105 4ZSG-A nrPDB 376 e-105 3E7O-A nrPDB 370 e-103 5Z33-A nrPDB 368 e-102 2F9G-A nrPDB 365 e-101 3FI2-A nrPDB 358 2e-99 4QNY-A nrPDB 343 1e-94 3OZ6-A nrPDB 337 5e-93 4O2Z-A nrPDB 329 8e-91 2BPM-A nrPDB 327 4e-90 3NIZ-A nrPDB 320 5e-88 3RP9-A nrPDB 319 8e-88 3N9X-A nrPDB 314 3e-86 3NIE-A nrPDB 311 2e-85 3PG1-A nrPDB 310 5e-85 6GU6-A nrPDB 310 6e-85 3NCG-A nrPDB 303 8e-83 4AU8-A nrPDB 302 1e-82 4KRC-A nrPDB 302 2e-82 1V0B-A nrPDB 300 6e-82 3DFA-A nrPDB 299 9e-82 2I6L-A nrPDB 296 9e-81 5JN2-A nrPDB 296 2e-80 3DXN-A nrPDB 295 2e-80 1UA2-A nrPDB 295 2e-80 3MA6-A nrPDB 294 3e-80 4AGU-A nrPDB 293 9e-80 5EFQ-A nrPDB 291 2e-79 3LIJ-A nrPDB 291 3e-79 4NST-A nrPDB 291 5e-79 4BBM-A nrPDB 290 7e-79 3HZT-A nrPDB 289 1e-78 3MIA-A nrPDB 286 1e-77 1G3N-A nrPDB 284 3e-77 5AIR-A nrPDB 284 5e-77 4MVF-A nrPDB 281 5e-76 5Y86-A nrPDB 280 8e-76 3Q5I-A nrPDB 275 2e-74 5G6V-A nrPDB 275 2e-74 2W96-B nrPDB 275 2e-74 4RGJ-A nrPDB 275 2e-74 2VN9-A nrPDB 274 3e-74 2V7O-A nrPDB 274 6e-74 5U6Y-A nrPDB 274 6e-74 2VZ6-A nrPDB 273 7e-74 5FG8-A nrPDB 272 1e-73 4YZB-A nrPDB 272 2e-73 4CFF-A nrPDB 272 2e-73 3MN3-A nrPDB 271 3e-73 4REW-A nrPDB 271 4e-73 5EZV-A nrPDB 271 4e-73 3ZDU-A nrPDB 271 5e-73 2JDO-A nrPDB 270 6e-73 2BDW-A nrPDB 269 1e-72 3SOA-A nrPDB 269 2e-72 4E7W-A nrPDB 268 2e-72 3BHH-A nrPDB 268 3e-72 3GC0-A nrPDB 267 4e-72 3H4J-B nrPDB 267 6e-72 5ES1-A nrPDB 267 6e-72 4BGQ-A nrPDB 266 8e-72 3KK8-A nrPDB 265 2e-71 5KZ7-A nrPDB 265 2e-71 4RED-A nrPDB 265 2e-71 4CFH-A nrPDB 265 2e-71 5ZTN-A nrPDB 263 7e-71 2QNJ-A nrPDB 262 2e-70 5IG1-A nrPDB 262 2e-70 2YCR-A nrPDB 259 1e-69 3E3P-A nrPDB 258 3e-69 3EB0-A nrPDB 256 8e-69 5WAX-A nrPDB 256 9e-69 5YKS-A nrPDB 256 1e-68 4CZT-A nrPDB 255 2e-68 4FG9-A nrPDB 255 2e-68 3IS5-A nrPDB 255 2e-68 2JC6-A nrPDB 254 4e-68 4D2V-A nrPDB 254 7e-68 4CQG-A nrPDB 252 1e-67 3F3Z-A nrPDB 252 2e-67 3COM-A nrPDB 252 2e-67 3I6U-A nrPDB 251 3e-67 5JZN-A nrPDB 251 3e-67 3MV5-A nrPDB 251 4e-67 2YZA-A nrPDB 250 5e-67 5XZW-A nrPDB 250 6e-67 4JG6-A nrPDB 249 1e-66 4NIF-A nrPDB 249 1e-66 3D2K-A nrPDB 249 1e-66 3ZUT-A nrPDB 249 1e-66 2J90-A nrPDB 249 1e-66 3UC3-A nrPDB 249 1e-66 2HAK-A nrPDB 249 2e-66 6FD3-A nrPDB 249 2e-66 4UZD-A nrPDB 248 2e-66 2JAM-A nrPDB 248 3e-66 4D28-A nrPDB 248 3e-66 6C9D-A nrPDB 248 3e-66 4LG4-A nrPDB 246 1e-65 2HW6-A nrPDB 246 1e-65 2YAB-A nrPDB 245 2e-65 5KCV-A nrPDB 245 2e-65 3UDB-A nrPDB 245 2e-65 4L42-A nrPDB 245 3e-65 5D9K-A nrPDB 244 3e-65 2Y7J-A nrPDB 244 5e-65 3GUB-A nrPDB 244 5e-65 3DB8-A nrPDB 244 7e-65 6AO5-A nrPDB 244 7e-65 3DAK-A nrPDB 244 7e-65 2F57-A nrPDB 243 1e-64 2A27-A nrPDB 242 1e-64 4JXF-A nrPDB 242 1e-64 4PDS-A nrPDB 242 2e-64 1PHK-A nrPDB 242 2e-64 4KS7-A nrPDB 242 2e-64 1FOT-A nrPDB 242 2e-64 4B6L-A nrPDB 242 2e-64 5D7A-A nrPDB 240 6e-64 4FIE-A nrPDB 240 7e-64 3HKO-A nrPDB 240 8e-64 2Q0N-A nrPDB 240 9e-64 4JDH-A nrPDB 239 1e-63 4XBR-A nrPDB 239 1e-63 3TAC-A nrPDB 239 2e-63 3Q53-A nrPDB 239 2e-63 2W4O-A nrPDB 239 2e-63 5J5T-A nrPDB 238 3e-63 4CSV-A nrPDB 237 4e-63 2OU7-A nrPDB 237 6e-63 1ZWS-A nrPDB 237 7e-63 4I6B-A nrPDB 237 8e-63 2Z7Q-A nrPDB 236 1e-62 3HDN-A nrPDB 235 1e-62 4J52-A nrPDB 235 2e-62 4RLP-A nrPDB 235 2e-62 3UTO-A nrPDB 234 4e-62 6FDY-U nrPDB 234 4e-62 2X4F-A nrPDB 234 4e-62 5DBX-A nrPDB 234 5e-62 6CKI-A nrPDB 234 5e-62 1U5R-A nrPDB 234 5e-62 6CMJ-A nrPDB 234 7e-62 4YNZ-A nrPDB 234 7e-62 3TXO-A nrPDB 233 9e-62 2XIK-A nrPDB 232 1e-61 4QMW-A nrPDB 232 2e-61 1KOA-A nrPDB 232 2e-61 4U41-A nrPDB 231 4e-61 5X8I-B nrPDB 231 4e-61 2GCD-A nrPDB 231 4e-61 4FZF-B nrPDB 230 5e-61 6O6Q-A nrPDB 230 5e-61 3LM0-A nrPDB 230 8e-61 2WO6-A nrPDB 230 1e-60 2UV2-A nrPDB 230 1e-60 3KN6-A nrPDB 229 2e-60 5X3F-B nrPDB 229 2e-60 1KOB-A nrPDB 229 2e-60 5F9E-A nrPDB 228 3e-60 6FYV-A nrPDB 228 3e-60 6ED6-A nrPDB 227 5e-60 5XVU-A nrPDB 227 9e-60 4WB7-A nrPDB 226 1e-59 6E9W-A nrPDB 226 1e-59 4GS6-A nrPDB 226 1e-59 5YV8-A nrPDB 225 2e-59 1VZO-A nrPDB 225 3e-59 5DYK-A nrPDB 224 5e-59 3ORZ-A nrPDB 224 6e-59 5N23-A nrPDB 224 6e-59 6F3F-A nrPDB 223 8e-59 2H8H-A nrPDB 223 9e-59 6HXF-B nrPDB 222 2e-58 5FET-A nrPDB 222 3e-58 4WNO-A nrPDB 220 6e-58 4B8L-A nrPDB 220 6e-58 4RA4-A nrPDB 220 9e-58 4CRL-A nrPDB 220 1e-57 4APC-A nrPDB 219 1e-57 5LOH-A nrPDB 219 2e-57 4C0T-A nrPDB 219 2e-57 2WTK-C nrPDB 218 4e-57 3RAW-A nrPDB 217 5e-57 5SYS-A nrPDB 217 6e-57 4MD7-E nrPDB 217 8e-57 4XEY-B nrPDB 217 9e-57 2FO0-A nrPDB 216 1e-56 3A8W-A nrPDB 216 1e-56 2DQ7-X nrPDB 216 1e-56 2XYN-A nrPDB 216 1e-56 6HMD-A nrPDB 215 2e-56 3NYO-A nrPDB 215 2e-56 6QAU-A nrPDB 215 2e-56 4AF3-A nrPDB 214 4e-56 6NPU-A nrPDB 214 4e-56 3TKU-A nrPDB 214 4e-56 3PFQ-A nrPDB 214 6e-56 6E2O-A nrPDB 213 1e-55 3FXW-A nrPDB 213 1e-55 2PVN-A nrPDB 213 1e-55 5UNP-A nrPDB 213 1e-55 6CQF-A nrPDB 212 1e-55 3ALO-A nrPDB 212 2e-55 6EII-A nrPDB 212 2e-55 2BRG-A nrPDB 211 3e-55 6BDL-A nrPDB 211 4e-55 6GQK-A nrPDB 211 4e-55 2I0E-A nrPDB 210 6e-55 1NY3-A nrPDB 210 7e-55 3VN9-A nrPDB 210 7e-55 4AW2-A nrPDB 210 1e-54 3PPZ-A nrPDB 209 1e-54 2OZA-A nrPDB 209 1e-54 4FR4-A nrPDB 208 2e-54 6CCF-A nrPDB 208 2e-54 4IAN-A nrPDB 208 3e-54 3KA0-A nrPDB 208 3e-54 3FME-A nrPDB 207 7e-54 2WQN-A nrPDB 207 8e-54 4OTD-A nrPDB 206 1e-53 3A4O-X nrPDB 206 1e-53 4CRS-A nrPDB 206 2e-53 1K9A-A nrPDB 205 2e-53 4UY9-A nrPDB 205 2e-53 2XNP-A nrPDB 205 3e-53 4EBW-A nrPDB 205 3e-53 5VO2-A nrPDB 205 3e-53 5O2B-A nrPDB 205 4e-53 1BYG-A nrPDB 204 4e-53 2OGV-A nrPDB 204 5e-53 3DTC-A nrPDB 204 5e-53 4XCU-A nrPDB 204 5e-53 4E93-A nrPDB 204 5e-53 4TNB-A nrPDB 203 6e-53 6DBM-A nrPDB 203 7e-53 3BEA-A nrPDB 203 8e-53 5H2U-A nrPDB 203 1e-52 4UYA-A nrPDB 203 1e-52 5O2C-A nrPDB 203 1e-52 4EQM-A nrPDB 203 1e-52 3G0E-A nrPDB 203 1e-52 6GVJ-A nrPDB 203 1e-52 5KKR-C nrPDB 203 1e-52 3TT0-A nrPDB 202 1e-52 4KIK-B nrPDB 202 2e-52 3KRL-A nrPDB 202 2e-52 3EQC-A nrPDB 202 2e-52 1ZXE-A nrPDB 202 2e-52 4PWN-A nrPDB 202 3e-52 1TKI-A nrPDB 201 3e-52 2J0K-A nrPDB 201 4e-52 5A46-A nrPDB 201 4e-52 2PL0-A nrPDB 201 4e-52 5AP3-A nrPDB 200 6e-52 4OLI-A nrPDB 200 6e-52 2HK5-A nrPDB 200 6e-52 4AN9-A nrPDB 200 7e-52 3GQL-A nrPDB 200 7e-52 2VD5-A nrPDB 200 7e-52 2Y6O-A nrPDB 200 7e-52 2JD5-A nrPDB 200 9e-52 5HI2-A nrPDB 199 2e-51 4K33-A nrPDB 199 2e-51 4P5Q-A nrPDB 199 2e-51 6E4F-A nrPDB 199 2e-51 3HMP-A nrPDB 199 2e-51 5TQX-A nrPDB 198 2e-51 1JPA-A nrPDB 198 3e-51 5UUU-A nrPDB 198 3e-51 3QGY-A nrPDB 198 3e-51 5MJB-A nrPDB 198 3e-51 3V5Q-A nrPDB 198 4e-51 3PVW-A nrPDB 197 4e-51 5AMN-A nrPDB 197 5e-51 3CJF-A nrPDB 197 5e-51 2PSQ-A nrPDB 197 7e-51 3QA8-A nrPDB 197 8e-51 5HIE-A nrPDB 197 8e-51 5X02-A nrPDB 197 9e-51 5L6P-A nrPDB 197 1e-50 4XI2-A nrPDB 197 1e-50 4XUF-A nrPDB 196 1e-50 2ZMD-A nrPDB 196 1e-50 4Y93-A nrPDB 196 1e-50 5EG3-A nrPDB 196 1e-50 3C51-A nrPDB 196 1e-50 1AD5-A nrPDB 196 1e-50 2R2P-A nrPDB 196 1e-50 4XLV-A nrPDB 196 2e-50 4R7H-A nrPDB 196 2e-50 5KMM-A nrPDB 196 2e-50 4WUA-A nrPDB 195 3e-50 4AT3-A nrPDB 195 3e-50 5X5O-A nrPDB 195 3e-50 2VWV-A nrPDB 194 4e-50 3DKO-A nrPDB 194 5e-50 1S9I-A nrPDB 194 5e-50 2X7G-A nrPDB 193 7e-50 6BXI-A nrPDB 193 8e-50 3ORP-A nrPDB 193 9e-50 4E20-A nrPDB 193 9e-50 5GRN-A nrPDB 192 1e-49 5FM2-A nrPDB 192 2e-49 2W1I-A nrPDB 192 2e-49 3IO7-A nrPDB 192 2e-49 3OMV-A nrPDB 192 2e-49 3LLT-A nrPDB 192 3e-49 4M7I-A nrPDB 191 4e-49 4YHJ-A nrPDB 191 5e-49 5B2L-A nrPDB 191 5e-49 3SXS-A nrPDB 190 8e-49 5U6B-A nrPDB 190 8e-49 3KUL-B nrPDB 190 1e-48 3DLS-A nrPDB 189 1e-48 3QUP-A nrPDB 188 3e-48 1FVR-A nrPDB 188 3e-48 6DBN-A nrPDB 188 3e-48 5O0Y-A nrPDB 188 3e-48 1LUF-A nrPDB 188 3e-48 4PDO-A nrPDB 188 4e-48 4HZS-A nrPDB 186 1e-47 3BBT-B nrPDB 186 2e-47 4YFF-A nrPDB 185 2e-47 5HLW-A nrPDB 185 2e-47 4LFI-A nrPDB 185 2e-47 3ZBF-A nrPDB 185 2e-47 4H1J-A nrPDB 185 3e-47 5TUR-A nrPDB 185 3e-47 3BGP-A nrPDB 185 3e-47 5U6C-A nrPDB 185 3e-47 4X7Q-B nrPDB 185 3e-47 3C1X-A nrPDB 185 4e-47 1U54-B nrPDB 184 4e-47 6B2Q-A nrPDB 184 5e-47 4X3F-A nrPDB 184 5e-47 4OW8-A nrPDB 184 5e-47 4HVI-A nrPDB 183 7e-47 5VD3-A nrPDB 183 8e-47 2WTK-B nrPDB 183 9e-47 4RC3-A nrPDB 183 1e-46 6FEX-A nrPDB 183 1e-46 3M42-A nrPDB 183 1e-46 1U59-A nrPDB 183 1e-46 3I81-A nrPDB 183 1e-46 3PLS-A nrPDB 182 2e-46 6BSD-A nrPDB 182 2e-46 5UIU-A nrPDB 182 3e-46 4C59-A nrPDB 182 3e-46 4Y83-A nrPDB 182 3e-46 5HVK-A nrPDB 181 4e-46 2OZO-A nrPDB 181 4e-46 3PP0-A nrPDB 180 9e-46 5TOS-A nrPDB 179 2e-45 6CTH-A nrPDB 178 4e-45 4NEU-A nrPDB 177 6e-45 2A1A-B nrPDB 177 6e-45 3Q4U-A nrPDB 177 7e-45 5GNK-A nrPDB 177 8e-45 6FER-A nrPDB 177 1e-44 3LZB-A nrPDB 177 1e-44 6HV0-A nrPDB 176 2e-44 4PL5-B nrPDB 175 3e-44 2RIO-A nrPDB 174 5e-44 4EUU-A nrPDB 173 1e-43 4JLC-A nrPDB 172 2e-43 4TPT-A nrPDB 172 2e-43 4EUT-A nrPDB 172 2e-43 3UIU-A nrPDB 172 3e-43 4IDT-A nrPDB 171 4e-43 3MDY-A nrPDB 171 4e-43 4LRM-A nrPDB 171 5e-43 6O8B-A nrPDB 170 9e-43 6NT9-A nrPDB 169 1e-42 2PMN-X nrPDB 169 2e-42 1PY5-A nrPDB 169 2e-42 3QD2-B nrPDB 168 3e-42 5WNL-A nrPDB 168 3e-42 4F0G-A nrPDB 168 3e-42 2BUJ-A nrPDB 167 8e-42 5LPZ-A nrPDB 167 9e-42 5LPV-A nrPDB 165 2e-41 3SOC-A nrPDB 165 3e-41 4FL3-A nrPDB 165 3e-41 6J5U-C nrPDB 164 7e-41 3MY0-A nrPDB 162 2e-40 5C26-A nrPDB 162 2e-40 4G3E-A nrPDB 162 3e-40 5TE0-A nrPDB 161 5e-40 3ZZW-A nrPDB 160 1e-39 5WNO-A nrPDB 158 3e-39 4F9B-A nrPDB 157 5e-39 5XD6-A nrPDB 157 6e-39 3G2F-A nrPDB 156 1e-38 2H34-A nrPDB 156 2e-38 5AR8-A nrPDB 155 2e-38 3UIM-A nrPDB 153 8e-38 5E8V-A nrPDB 153 8e-38 4M66-A nrPDB 153 9e-38 2QKW-B nrPDB 152 2e-37 2Y4I-B nrPDB 152 2e-37 5IKW-A nrPDB 151 3e-37 6DC0-A nrPDB 150 8e-37 5CEK-A nrPDB 150 9e-37 3SV0-A nrPDB 149 2e-36 6BFN-A nrPDB 147 7e-36 3LMG-A nrPDB 147 8e-36 4TN6-A nrPDB 147 8e-36 2QLU-A nrPDB 146 9e-36 4BTK-A nrPDB 146 1e-35 4NFN-A nrPDB 145 3e-35 2CHL-A nrPDB 144 5e-35 5J0A-A nrPDB 143 8e-35 5FQD-C nrPDB 143 9e-35 4LQP-A nrPDB 143 9e-35 5VC6-A nrPDB 143 2e-34 5L2Q-C nrPDB 138 2e-33 2CMW-A nrPDB 138 3e-33 2C47-A nrPDB 138 4e-33 4NT4-A nrPDB 136 1e-32 4M69-B nrPDB 136 1e-32 4BTF-A nrPDB 136 1e-32 2PZI-A nrPDB 130 1e-30 4Y12-A nrPDB 129 2e-30 3VHK-A nrPDB 128 3e-30 4XHH-A nrPDB 126 1e-29 3HNG-A nrPDB 126 1e-29 4RT7-A nrPDB 126 1e-29 4JRN-A nrPDB 126 2e-29 4XHL-A nrPDB 125 3e-29 5X1R-A nrPDB 120 1e-27 4L68-A nrPDB 112 2e-25 5CLR-A nrPDB 104 5e-23 4CI6-B nrPDB 103 2e-22 4IX6-A nrPDB 97 1e-20 Sequences not found previously or not previously below threshold: 3AOX-A nrPDB 164 7e-41 5VDK-A nrPDB 128 4e-30 5X18-A nrPDB 127 8e-30 4MWI-A nrPDB 124 5e-29 1CSN-A nrPDB 123 1e-28 4L00-A nrPDB 112 2e-25 5M07-A nrPDB 107 6e-24 5OAT-A nrPDB 106 2e-23 5USZ-A nrPDB 105 3e-23 3REP-A nrPDB 103 1e-22 6EQI-C nrPDB 101 4e-22 5UV4-A nrPDB 100 7e-22 4I94-A nrPDB 97 1e-20 5C01-A nrPDB 94 7e-20 4WOV-A nrPDB 94 1e-19 6J6I-B nrPDB 87 9e-18 5UU1-A nrPDB 87 2e-17 2RSV-A nrPDB 78 8e-15 2LAV-A nrPDB 76 2e-14 5DMZ-A nrPDB 71 7e-13 6G4J-A nrPDB 69 3e-12 4O1O-A nrPDB 67 1e-11 4OAU-C nrPDB 65 7e-11 6M7Z-A nrPDB 63 2e-10 2JII-A nrPDB 62 4e-10 6EWX-A nrPDB 61 1e-09 3ENH-A nrPDB 60 2e-09 6EAS-A nrPDB 56 2e-08 6G38-A nrPDB 56 3e-08 4AZW-A nrPDB 55 5e-08 6BHC-A nrPDB 54 8e-08 4CYJ-A nrPDB 54 9e-08 4AZV-A nrPDB 54 9e-08 5GZA-A nrPDB 53 2e-07 5VE6-A nrPDB 51 6e-07 4WWA-A nrPDB 50 1e-06 5GZ9-A nrPDB 50 2e-06 3BYV-A nrPDB 46 2e-05 4BWP-A nrPDB 46 3e-05 3Q60-A nrPDB 45 5e-05 2W1Z-A nrPDB 43 3e-04 3DZO-A nrPDB 42 5e-04 1TQM-A nrPDB 42 5e-04 6R5K-O nrPDB 41 6e-04 4XR7-L nrPDB 40 0.002 5YK0-A nrPDB 39 0.003 4CZY-B nrPDB 39 0.004 6G18-v nrPDB 38 0.010 6FDN-A nrPDB 36 0.017 4ESA-B nrPDB 34 0.097 4UP8-A nrPDB 32 0.33 6FAI-l nrPDB 32 0.35 4BVU-A nrPDB 32 0.37 5N28-B nrPDB 31 0.88 >3GC9-A nrPDB Length = 370 Score = 544 bits (1401), Expect = e-155, Method: Composition-based stats. Identities = 362/364 (99%), Positives = 362/364 (99%) Query: 1 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 60 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ Sbjct: 7 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 66 Query: 61 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ 120 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK Q Sbjct: 67 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQ 126 Query: 121 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT 180 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED ELRILDFGLARQADEEMT Sbjct: 127 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMT 186 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG Sbjct: 187 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 246 Query: 241 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 300 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA Sbjct: 247 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 306 Query: 301 EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL 360 EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL Sbjct: 307 EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL 366 Query: 361 EIEQ 364 EIEQ Sbjct: 367 EIEQ 370 >4EWQ-A nrPDB Length = 383 Score = 487 bits (1254), Expect = e-138, Method: Composition-based stats. Identities = 264/350 (75%), Positives = 311/350 (88%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 61 S R FYRQELNKT+WEVP+R Q L PVGSGAYGSVC+A+D + +VAVKKLSRPFQS Sbjct: 25 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 84 Query: 62 LIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA 121 +IHA+RTYRELRLLKH+KHENVIGLLDVFTPA S+E+F++VYLVT LMGADLNNIVKCQ Sbjct: 85 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 144 Query: 122 LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTG 181 L+D+HVQFL+YQ+LRGLKYIHSA IIHRDLKPSN+AVNEDCEL+ILDFGLAR D+EMTG Sbjct: 145 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG 204 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGT 241 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL G+ LFPG+D+IDQLK I+ +VGT Sbjct: 205 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGT 264 Query: 242 PSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAE 301 P E+L KISSE AR YIQSL MP+ + +++F GANPLA+DLL +MLVLDSD+R++AA+ Sbjct: 265 PGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQ 324 Query: 302 ALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPP 351 ALAHAYF+QYHDP+DEP A+PYD+S E+++ ++EWK LTY EV+SF PP Sbjct: 325 ALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPP 374 >3OHT-A nrPDB Length = 389 Score = 479 bits (1232), Expect = e-135, Method: Composition-based stats. Identities = 257/347 (74%), Positives = 308/347 (88%) Query: 5 RAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH 64 R FYRQELNKT+WEVP+R Q L PVGSGAYGSVCS+YD + K+AVKKLSRPFQS+IH Sbjct: 34 RPTFYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIH 93 Query: 65 ARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSD 124 A+RTYRELRLLKH+KHENVIGLLDVFTPATS+E+F++VYLVT LMGADLNNIVKCQ L+D Sbjct: 94 AKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKLTD 153 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVA 184 +HVQFL+YQ+LRGLKYIHSA IIHRDLKPSN+AVNEDCEL+ILDFGLAR D+EMTGYVA Sbjct: 154 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVA 213 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSP 244 TRWYRAPEIMLNWMHYN TVDIWSVGCIMAELL G+ LFPG+D+I+QL++IM + GTP Sbjct: 214 TRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPA 273 Query: 245 EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 V++++ S AR YI SLP MP+++ + +F GANPLA+DLL +MLVLD+D+R++A+EALA Sbjct: 274 SVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALA 333 Query: 305 HAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPP 351 H YFSQYHDP+DEPE+EPYD+S E+++ +EEWK LTY+EV SF+ P Sbjct: 334 HPYFSQYHDPDDEPESEPYDQSFESRQLEIEEWKRLTYEEVCSFETP 380 >1CM8-A nrPDB Length = 367 Score = 451 bits (1160), Expect = e-127, Method: Composition-based stats. Identities = 225/354 (63%), Positives = 284/354 (80%), Gaps = 3/354 (0%) Query: 1 MSGP---RAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR 57 MS P R+GFYRQE+ KT WEV + L+PVGSGAYG+VCSA D R KVA+KKL R Sbjct: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 Query: 58 PFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV 117 PFQS + A+R YRELRLLKH++HENVIGLLDVFTP +++DF++ YLV MG DL ++ Sbjct: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120 Query: 118 KCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE 177 K + L ++ +QFLVYQ+L+GL+YIH+AGIIHRDLKP N+AVNEDCEL+ILDFGLARQAD Sbjct: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180 Query: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME 237 EMTGYV TRWYRAPE++LNWM Y QTVDIWSVGCIMAE++ GK LF GSD++DQLK IM+ Sbjct: 181 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 Query: 238 VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV 297 V GTP E + ++ S+ A+ Y++ LP + +KD +SI A+PLA++LL +MLVLD++QRV Sbjct: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 Query: 298 SAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPP 351 +A EALAH YF HD EDEP+ + YD+S + +RTL+EWK +TY+EVLSFKPP Sbjct: 301 TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354 >4MYG-A nrPDB Length = 372 Score = 428 bits (1102), Expect = e-120, Method: Composition-based stats. Identities = 210/347 (60%), Positives = 274/347 (78%), Gaps = 2/347 (0%) Query: 5 RAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH 64 + GFY+Q++NKT WE+P+ VGSGAYGSVCSA D R +KVA+KKLSRPFQS I Sbjct: 26 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 85 Query: 65 ARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSD 124 A+R YREL LLKH++HENVIGLLDVFTPA+S+ +F + YLV M DL I+ S+ Sbjct: 86 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-GMEFSE 144 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVA 184 E +Q+LVYQ+L+GLKYIHSAG++HRDLKP N+AVNEDCEL+ILDFGLAR AD EMTGYV Sbjct: 145 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV 204 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSP 244 TRWYRAPE++L+WMHYNQTVDIWSVGCIMAE+L GK LF G DY+DQL +I++V G P Sbjct: 205 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 264 Query: 245 EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 E + K++ + A++YIQSLP P+KD + +F A+P A DLL +ML LD D+R++AA+AL Sbjct: 265 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 324 Query: 305 HAYFSQYHDPEDEPEA-EPYDESVEAKERTLEEWKELTYQEVLSFKP 350 H +F + DPE+E EA +P+D+S+E ++ T++EWK+ Y+E+++F P Sbjct: 325 HPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 371 >5AWM-A nrPDB Length = 394 Score = 386 bits (991), Expect = e-108, Method: Composition-based stats. Identities = 170/366 (46%), Positives = 241/366 (65%), Gaps = 20/366 (5%) Query: 1 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 60 M+ + Y E+ T + + R LRP+GSGA G VC+AYD +Q VA+KKLSRPFQ Sbjct: 23 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ 82 Query: 61 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ 120 ++ HA+R YRE +L+K + H+N+IGLL+ FTP ++E+F +VYLV LM A+L +++ Sbjct: 83 NVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD 142 Query: 121 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE-- 178 L + + +L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A Sbjct: 143 -LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM 201 Query: 179 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 238 MT YV TR+YRAPE++L M Y + VDIWSVGCIM E+++G LFPG+D+IDQ +I+E Sbjct: 202 MTPYVVTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 260 Query: 239 VGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGA-------------NPLAIDLL 285 +GTPSP + ++ R Y+++ P +F A +LL Sbjct: 261 LGTPSPSFMQRLQPT-VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLL 319 Query: 286 GRMLVLDSDQRVSAAEALAHAYFSQYHDPE--DEPEAEPYDESVEAKERTLEEWKELTYQ 343 +MLV+D +QR+S EAL H Y + ++D E D P EPYD SV+ +E T+E+WKEL Y+ Sbjct: 320 SKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYE 379 Query: 344 EVLSFK 349 EV+ ++ Sbjct: 380 EVMDYE 385 >4QTB-A nrPDB Length = 380 Score = 379 bits (974), Expect = e-106, Method: Composition-based stats. Identities = 162/340 (47%), Positives = 231/340 (67%), Gaps = 9/340 (2%) Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77 ++V R L+ +G GAYG V SAYD + +VA+KK+S PF+ + +RT RE+++L Sbjct: 37 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 95 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRG 137 +HENVIG+ D+ A+++E +VY+V LM DL ++K Q LS++H+ + +YQ+LRG Sbjct: 96 FRHENVIGIRDI-LRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 154 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE------MTGYVATRWYRAP 191 LKYIHSA ++HRDLKPSN+ +N C+L+I DFGLAR AD E +T YVATRWYRAP Sbjct: 155 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 214 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 EIMLN Y +++DIWSVGCI+AE+L + +FPG Y+DQL I+ ++G+PS E L I Sbjct: 215 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 274 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 + AR Y+QSLP + + +F ++ A+DLL RML + ++R++ EALAH Y QY Sbjct: 275 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 334 Query: 312 HDPEDEPEA-EPYDESVEAKERTLEEWKELTYQEVLSFKP 350 +DP DEP A EP+ ++E + E KEL +QE F+P Sbjct: 335 YDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQP 374 >4IC8-A nrPDB Length = 442 Score = 379 bits (973), Expect = e-105, Method: Composition-based stats. Identities = 159/344 (46%), Positives = 223/344 (64%), Gaps = 9/344 (2%) Query: 15 KTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRL 74 ++V + + +G+GAYG V SA Q+VA+KK+ F + +A+RT REL++ Sbjct: 48 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 107 Query: 75 LKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-QALSDEHVQFLVYQ 133 LKH KH+N+I + D+ P +F VY+V LM +DL+ I+ Q L+ EHV++ +YQ Sbjct: 108 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 167 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR-------QADEEMTGYVATR 186 LLRGLKY+HSA +IHRDLKPSN+ VNE+CEL+I DFG+AR + MT YVATR Sbjct: 168 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 227 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEV 246 WYRAPE+ML+ Y Q +D+WSVGCI E+L + LFPG +Y+ QL+ IM V+GTPSP V Sbjct: 228 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 287 Query: 247 LAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHA 306 + + +E R YIQSLPP +++ GA+ A+ LLGRML + R+SAA AL H Sbjct: 288 IQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHP 347 Query: 307 YFSQYHDPEDEPEA-EPYDESVEAKERTLEEWKELTYQEVLSFK 349 + ++YHDP+DEP+ P+D + + + T E KE E+ F Sbjct: 348 FLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFH 391 >6DTL-A nrPDB Length = 364 Score = 377 bits (969), Expect = e-105, Method: Composition-based stats. Identities = 157/348 (45%), Positives = 232/348 (66%), Gaps = 7/348 (2%) Query: 8 FYRQELNKTVWEVPQRLQG-LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR 66 F + + ++EV + + + P+G GAYG VCSA ++ + VA+KK++ F + I A+ Sbjct: 15 FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK 74 Query: 67 RTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-QALSDE 125 RT RE++LL+H+ HEN++ + D+ P F++VY+ LM DL+ I++ QALS+E Sbjct: 75 RTLREIKLLRHMDHENIVAIRDII-PPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEE 133 Query: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYV 183 H Q+ +YQ+LRGLKYIHSA ++HRDLKPSN+ +N +C+L+I DFGLAR E MT YV Sbjct: 134 HCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYV 193 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPS 243 TRWYRAPE++LN Y +D+WSVGCI EL+ K LFPG D++ QL+ +ME++GTPS Sbjct: 194 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS 253 Query: 244 PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEAL 303 + +E+A+ YI+ LPP P++ ++ F +PLAIDL+ +ML D +R++ +AL Sbjct: 254 E-EELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 312 Query: 304 AHAYFSQYHDPEDEPEAE-PYDESVEAKERTLEEWKELTYQEVLSFKP 350 AH Y + HD DEPE P++ E + E+ KEL Y+E L+F P Sbjct: 313 AHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNP 360 >2XS0-A nrPDB Length = 386 Score = 377 bits (969), Expect = e-105, Method: Composition-based stats. Identities = 169/364 (46%), Positives = 240/364 (65%), Gaps = 19/364 (5%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 61 S FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ Sbjct: 6 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 65 Query: 62 LIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA 121 HA+R YREL L+K + H+N+IGLL+VFTP S+E+F +VY+V LM A+L +++ + Sbjct: 66 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME- 124 Query: 122 LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--M 179 L E + +L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A M Sbjct: 125 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 184 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVV 239 +V TR+YRAPE++L M Y + VDIWSVGCIM E+++G LFPG+D+IDQ +++E + Sbjct: 185 VPFVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 243 Query: 240 GTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGA------------NPLAIDLLGR 287 GTP PE + K+ RTY+++ P +F A DLL + Sbjct: 244 GTPCPEFMKKLQPT-VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 302 Query: 288 MLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEP--YDESVEAKERTLEEWKELTYQEV 345 MLV+D+ +R+S EAL H Y + ++DP + P D+ ++ +E T+EEWKEL Y+EV Sbjct: 303 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 362 Query: 346 LSFK 349 + + Sbjct: 363 MDLE 366 >5NGU-A nrPDB Length = 381 Score = 377 bits (968), Expect = e-105, Method: Composition-based stats. Identities = 160/341 (46%), Positives = 227/341 (66%), Gaps = 9/341 (2%) Query: 17 VWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLK 76 V++V R L +G GAYG VCSAYD + +VA+KK+S PF+ + +RT RE+++L Sbjct: 37 VFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLREIKILL 95 Query: 77 HLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLR 136 +HEN+IG+ D+ T IE +VY+V LM DL ++K Q LS++H+ + +YQ+LR Sbjct: 96 RFRHENIIGINDIIRAPT-IEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILR 154 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE------MTGYVATRWYRA 190 GLKYIHSA ++HRDLKPSN+ +N C+L+I DFGLAR AD + +T YVATRWYRA Sbjct: 155 GLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRA 214 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI 250 PEIMLN Y +++DIWSVGCI+AE+L + +FPG Y+DQL I+ ++G+PS E L I Sbjct: 215 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 274 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + AR Y+ SLP + + +F A+ A+DLL +ML + +R+ +ALAH Y Q Sbjct: 275 INLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 334 Query: 311 YHDPEDEPEAE-PYDESVEAKERTLEEWKELTYQEVLSFKP 350 Y+DP DEP AE P+ +E + E+ KEL ++E F+P Sbjct: 335 YYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQP 375 >1JNK-A nrPDB Length = 423 Score = 376 bits (967), Expect = e-105, Method: Composition-based stats. Identities = 173/363 (47%), Positives = 241/363 (66%), Gaps = 21/363 (5%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 61 S FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ Sbjct: 42 SKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQN 101 Query: 62 LIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA 121 HA+R YREL L+K + H+N+I LL+VFTP ++E+F +VYLV LM A+L +++ + Sbjct: 102 QTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME- 160 Query: 122 LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--M 179 L E + +L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A M Sbjct: 161 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 220 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVV 239 T YV TR+YRAPE++L M Y + VDIWSVGCIM E+++ K LFPG DYIDQ +++E + Sbjct: 221 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQL 279 Query: 240 GTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGA------------NPLAIDLLGR 287 GTP PE + K+ R Y+++ P +F + A DLL + Sbjct: 280 GTPCPEFMKKLQPT-VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 Query: 288 MLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQE 344 MLV+D +R+S +AL H Y + ++DP E EA P YD+ ++ +E T+EEWKEL Y+E Sbjct: 339 MLVIDPAKRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397 Query: 345 VLS 347 V++ Sbjct: 398 VMN 400 >4ZSG-A nrPDB Length = 347 Score = 376 bits (966), Expect = e-105, Method: Composition-based stats. Identities = 159/343 (46%), Positives = 223/343 (65%), Gaps = 9/343 (2%) Query: 16 TVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLL 75 ++V + + +G+GAYG V SA Q+VA+KK+ F + +A+RT REL++L Sbjct: 1 VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKIL 60 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-QALSDEHVQFLVYQL 134 KH KH+N+I + D+ P +F VY+V LM +DL+ I+ Q L+ EHV++ +YQL Sbjct: 61 KHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQL 120 Query: 135 LRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR-------QADEEMTGYVATRW 187 LRGLKY+HSA +IHRDLKPSN+ VNE+CEL+I DFG+AR + MT YVATRW Sbjct: 121 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 180 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 247 YRAPE+ML+ Y Q +D+WSVGCI E+L + LFPG +Y+ QL+ IM V+GTPSP V+ Sbjct: 181 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 240 Query: 248 AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 + +E R YIQSLPP +++ GA+ A+ LLGRML + R+SAA AL H + Sbjct: 241 QAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPF 300 Query: 308 FSQYHDPEDEPEA-EPYDESVEAKERTLEEWKELTYQEVLSFK 349 ++YHDP+DEP+ P+D + + + T E KE E+ F Sbjct: 301 LAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFH 343 >3E7O-A nrPDB Length = 360 Score = 370 bits (949), Expect = e-103, Method: Composition-based stats. Identities = 169/358 (47%), Positives = 234/358 (65%), Gaps = 19/358 (5%) Query: 6 AGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA 65 + FY ++ + + V +R Q L+P+GSGA G VC+A+D L VAVKKLSRPFQ+ HA Sbjct: 6 SQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHA 65 Query: 66 RRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDE 125 +R YREL LLK + H+N+I LL+VFTP ++E+F +VYLV LM A+L ++ + L E Sbjct: 66 KRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHE 124 Query: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYV 183 + +L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A MT YV Sbjct: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYV 184 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPS 243 TR+YRAPE++L M Y + VDIWSVGCIM EL++G +F G+D+IDQ +++E +GTPS Sbjct: 185 VTRYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPS 243 Query: 244 PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRG------------ANPLAIDLLGRMLVL 291 E +A + R Y+++ P P +F A DLL +MLV+ Sbjct: 244 AEFMAALQPT-VRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVI 302 Query: 292 DSDQRVSAAEALAHAYFSQYHDPEDEPEAEP--YDESVEAKERTLEEWKELTYQEVLS 347 D D+R+S EAL H Y + ++DP + P YD +E +E +EEWKEL Y+EV+ Sbjct: 303 DPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMD 360 >5Z33-A nrPDB Length = 425 Score = 368 bits (944), Expect = e-102, Method: Composition-based stats. Identities = 152/342 (44%), Positives = 217/342 (63%), Gaps = 13/342 (3%) Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77 + V +R + +G GAYG VC+A + + + VA+KK++ F I A+R RE++LL+H Sbjct: 27 FIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQH 86 Query: 78 LK-HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-QALSDEHVQFLVYQLL 135 + H N+ L D+ P ++F+E YL LM DL I++ Q L+D H Q +YQ+L Sbjct: 87 FRGHRNITCLYDMDIPRP--DNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQIL 144 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE-------MTGYVATRWY 188 GLKYIHSA ++HRDLKP N+ VN DCEL+I DFGLAR + MT YVATRWY Sbjct: 145 CGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWY 204 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLA 248 RAPEIML++ Y + +D+WSVGCI+AELL G+ F G DY+DQL +I+ ++GTP+ E L+ Sbjct: 205 RAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLS 264 Query: 249 KISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 +I S A+ Y+++LP M +K ++F ANP A+DLL RML D R+S +AL H Y Sbjct: 265 RIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYL 324 Query: 309 SQYHDPEDEPEAE-PYDESVEAKERTLEEWKELTYQEVLSFK 349 +HD DEP+ ++ E E + E +++ EV F+ Sbjct: 325 HIWHDASDEPDCPTTFNFDFEVVED-VGEMRKMILDEVYRFR 365 >2F9G-A nrPDB Length = 353 Score = 365 bits (938), Expect = e-101, Method: Composition-based stats. Identities = 156/352 (44%), Positives = 213/352 (60%), Gaps = 21/352 (5%) Query: 15 KTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRL 74 + V+ + Q +G GAYG VCSA + VA+KK+ PF + A RT RE+++ Sbjct: 4 RIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKI 62 Query: 75 LKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQL 134 LKH KHEN+I + ++ S E+F+EVY++ LM DL+ ++ Q LSD+H+Q+ +YQ Sbjct: 63 LKHFKHENIITIFNI-QRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQT 121 Query: 135 LRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE-------------MTG 181 LR +K +H + +IHRDLKPSN+ +N +C+L++ DFGLAR DE MT Sbjct: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGT 241 YVATRWYRAPE+ML Y++ +D+WS GCI+AEL + +FPG DY QL I ++GT Sbjct: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 Query: 242 P-SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 300 P S L I S AR YI+SLP P L +F NP IDLL RMLV D +R++A Sbjct: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 Query: 301 EALAHAYFSQYHDPEDEPEAEPYDESVEAKER-----TLEEWKELTYQEVLS 347 EAL H Y YHDP DEPE EP S + T ++ K+L + E+ S Sbjct: 302 EALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 >3FI2-A nrPDB Length = 353 Score = 358 bits (919), Expect = 2e-99, Method: Composition-based stats. Identities = 165/360 (45%), Positives = 231/360 (64%), Gaps = 26/360 (7%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 61 S FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ Sbjct: 4 SKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQN 63 Query: 62 LIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA 121 HA+R YREL L+K + H+N+I LL+VFTP ++E+F +VYLV LM A+L +++ + Sbjct: 64 QTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME- 122 Query: 122 LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--M 179 L E + +L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A M Sbjct: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVV 239 T YV TR+YRAPE++L M Y + VDIWSVGCIM E+++ K LFPG DYIDQ +++E + Sbjct: 183 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQL 241 Query: 240 GTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGA------------NPLAIDLLGR 287 GTP PE + K+ R Y+++ P +F + A DLL + Sbjct: 242 GTPCPEFMKKLQPT-VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 300 Query: 288 MLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLS 347 MLV+D +R+S +AL H Y + ++ + +E T+EEWKEL Y+EV++ Sbjct: 301 MLVIDPAKRISVDDALQHPYINVWYX---------XXXXXDEREHTIEEWKELIYKEVMN 351 >4QNY-A nrPDB Length = 354 Score = 343 bits (879), Expect = 1e-94, Method: Composition-based stats. Identities = 129/344 (37%), Positives = 210/344 (61%), Gaps = 7/344 (2%) Query: 12 ELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARL-RQKVAVKKLSRP-FQSLIHARRTY 69 EL V + R R +G+G+YG V A D + + VA+K++++ F+ +I A+R Sbjct: 10 ELQAEVCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRIL 69 Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-QALSDEHVQ 128 RE++LL H +N+IGL ++ TP E+F Y+V +M DL +++ Q L++ H+Q Sbjct: 70 REIKLLAHFNDDNIIGLRNILTPEDP-ENFDHFYIVMDIMETDLKQVLRSGQELTEAHIQ 128 Query: 129 FLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE---MTGYVAT 185 F +YQ LR L IHSAG+IHRD+ P+N+ VN +C+L+I DFGLA++ +++ MT YV Sbjct: 129 FFIYQALRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTM 188 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245 RWYRAPE+++ Y+ +D+W +GCI+ ELL + LF G D ++QL +I++V+GTPS E Sbjct: 189 RWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEE 248 Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAH 305 + + S A+ Y++ PQ D + A+P A+DLL MLV + +R++ +A+ H Sbjct: 249 DINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRH 308 Query: 306 AYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFK 349 + Q HD D+ + E +++T+ + K Y+E + F Sbjct: 309 PFLEQLHDDADDNLSYALFRFDENEQKTIVDVKRAIYEESVKFH 352 >3OZ6-A nrPDB Length = 388 Score = 337 bits (864), Expect = 5e-93, Method: Composition-based stats. Identities = 130/375 (34%), Positives = 219/375 (58%), Gaps = 53/375 (14%) Query: 19 EVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL 78 V ++ + ++ +G GAYG V + D R + VAVKK+ FQ+ A+RT+RE+ +L L Sbjct: 6 HVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTEL 65 Query: 79 K-HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRG 137 HEN++ LL+V ++ +VYLV M DL+ +++ L H Q++VYQL++ Sbjct: 66 SGHENIVNLLNVLR----ADNDRDVYLVFDYMETDLHAVIRANILEPVHKQYVVYQLIKV 121 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR---------------------QAD 176 +KY+HS G++HRD+KPSN+ +N +C +++ DFGL+R D Sbjct: 122 IKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFD 181 Query: 177 EE---MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLK 233 ++ +T YVATRWYRAPEI+L Y + +D+WS+GCI+ E+L GK +FPGS ++QL+ Sbjct: 182 DDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLE 241 Query: 234 RIMEVVGTPSPEVLAKISSEHARTYIQSLPPM------PQKDLSSIFRG----------A 277 RI+ V+ PS E + I S A+T I+SL ++D+ + ++ Sbjct: 242 RIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADC 301 Query: 278 NPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAE-----PYDESVEAKER 332 N A+DLL ++L + ++R+SA +AL H + S +H+P +EP + P +++V + Sbjct: 302 NEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPINDNV---KH 358 Query: 333 TLEEWKELTYQEVLS 347 ++++++ L Y E+ Sbjct: 359 SIDDYRNLVYSEISR 373 >4O2Z-A nrPDB Length = 377 Score = 329 bits (845), Expect = 8e-91, Method: Composition-based stats. Identities = 134/376 (35%), Positives = 208/376 (55%), Gaps = 33/376 (8%) Query: 2 SGPRAGFYRQ-----------------ELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDA 44 S R Y Q ++ + +EVP + L+ +G GAYG CS D Sbjct: 8 SSGRENLYFQGNQELSVPKIVGDFKVYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDG 67 Query: 45 RLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTP-ATSIEDFSEVY 103 +KV++KK F+ + +R RE+ +++ HEN++ ++++ P F +VY Sbjct: 68 DTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVY 127 Query: 104 LVTTLMGADLNNIVK-CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDC 162 +VT LM D+N +++ Q L + H+Q+ VYQ+LRGLKY+HSA + HRDLKP+N+ N C Sbjct: 128 VVTPLMDVDMNVVLRSRQVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISC 187 Query: 163 ELRILDFGLARQAD---EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQG 219 EL+I+DFGL+R D E+T YV TRWYR PE++L +Y+ VDIWSVGCI AE+ Sbjct: 188 ELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNR 247 Query: 220 KALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLS--SIFRGA 277 K +FPG + +DQL+ I + +G P ++ R ++ L +P L+ + G Sbjct: 248 KPVFPGRNTMDQLRMIAQHIGKPPASIV------EHREALEKLNELPDGSLNIPKLVPGL 301 Query: 278 --NPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAE-PYDESVEAKERTL 334 N ID L +M LD +R +AA+ LAH Y + HD EDEP P+ + E+ + Sbjct: 302 AGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHDEEDEPTCPCPFLWAHESTPMGV 361 Query: 335 EEWKELTYQEVLSFKP 350 E + + +++ + P Sbjct: 362 SELRRAFWADIVDYNP 377 >2BPM-A nrPDB Length = 309 Score = 327 bits (839), Expect = 4e-90, Method: Composition-based stats. Identities = 109/299 (36%), Positives = 161/299 (53%), Gaps = 14/299 (4%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + Q + +G G YG V A + + VA+KK+ ++ RE+ LLK L H Sbjct: 7 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 66 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALS---DEHVQFLVYQLLRGL 138 N++ LLDV I +++YLV + DL + AL+ ++ ++QLL+GL Sbjct: 67 NIVKLLDV------IHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 120 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY---VATRWYRAPEIML 195 + HS ++HRDLKP N+ +N + +++ DFGLAR + Y V T WYRAPEI+L Sbjct: 121 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 180 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 +Y+ VDIWS+GCI AE++ +ALFPG IDQL RI +GTP V ++S Sbjct: 181 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS--M 238 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 314 Y S P ++D S + + LL +ML D ++R+SA ALAH +F P Sbjct: 239 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 297 >3NIZ-A nrPDB Length = 311 Score = 320 bits (821), Expect = 5e-88, Method: Composition-based stats. Identities = 115/319 (36%), Positives = 166/319 (52%), Gaps = 21/319 (6%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 61 S R Y Q L ++ Q L VG G YG V A D++ + VA+K++ + Sbjct: 8 SSGRENLYFQGL-------MEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAED 59 Query: 62 LIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV--KC 119 RE+ LLK L H N++ L+DV + LV M DL ++ Sbjct: 60 EGIPSTAIREISLLKELHHPNIVSLIDVIHSERCLT------LVFEFMEKDLKKVLDENK 113 Query: 120 QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM 179 L D ++ +YQLLRG+ + H I+HRDLKP N+ +N D L++ DFGLAR + Sbjct: 114 TGLQDSQIKIYLYQLLRGVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPV 173 Query: 180 TGY---VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 Y V T WYRAP++++ Y+ +VDIWS+GCI AE++ GK LFPG DQL +I Sbjct: 174 RSYTHEVVTLWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIF 233 Query: 237 EVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQR 296 ++GTP+P ++ E ++ +K SSI G IDLL ML D ++R Sbjct: 234 SILGTPNPREWPQVQ-ELPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKR 292 Query: 297 VSAAEALAHAYFSQYHDPE 315 +SA +A+ H YF DP+ Sbjct: 293 ISARDAMNHPYFKDL-DPQ 310 >3RP9-A nrPDB Length = 458 Score = 319 bits (819), Expect = 8e-88, Method: Composition-based stats. Identities = 134/400 (33%), Positives = 208/400 (52%), Gaps = 71/400 (17%) Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77 W++P R + +G+G+YG VC AYD ++ VA+KK+ R F+ LI +R RE+ +L Sbjct: 49 WQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNR 108 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-LSDEHVQFLVYQLLR 136 L H++V+ +LD+ P +E F E+Y+V + +D + + L++ H++ L+Y LL Sbjct: 109 LNHDHVVKVLDIVIPKD-VEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNLLV 167 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE------------------- 177 G+KY+HSAGI+HRDLKP+N VN+DC +++ DFGLAR D Sbjct: 168 GVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNL 227 Query: 178 -----------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-------- 218 ++TG+V TRWYRAPE++L +Y + +D+WS+GCI AELL Sbjct: 228 VTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAY 287 Query: 219 ---GKALFPGSD--------------------YIDQLKRIMEVVGTPSPEVLAKISSEHA 255 LFPGS DQL I ++GTPS E + + E A Sbjct: 288 HADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDA 347 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPE 315 + YI+ P DL+ F ++ AI LL RMLV + ++R++ E LAH +F + E Sbjct: 348 KRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVRIAE 407 Query: 316 DEPEAE-----PYDESVEAKERTLEEWKELTYQEVLSFKP 350 E A P+++ + E + + +E+ + P Sbjct: 408 VETNATEKVRLPFNDWMNMDE---PQLRYAFVKEIQRYHP 444 >3N9X-A nrPDB Length = 432 Score = 314 bits (806), Expect = 3e-86, Method: Composition-based stats. Identities = 128/408 (31%), Positives = 197/408 (48%), Gaps = 65/408 (15%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 61 S R Y Q + VP +G G+YG V AYD + VA+KK++R F+ Sbjct: 8 SSGRENLYFQGIKNV--HVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFED 65 Query: 62 LIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ- 120 LI +R RE+ +L LK + +I L D+ P ++ F E+Y+V + +DL + K Sbjct: 66 LIDCKRILREITILNRLKSDYIIRLYDLIIPDDLLK-FDELYIVLEIADSDLKKLFKTPI 124 Query: 121 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE-- 178 L++EH++ ++Y LL G +IH +GIIHRDLKP+N +N+DC +++ DFGLAR + E Sbjct: 125 FLTEEHIKTILYNLLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKD 184 Query: 179 -----------------------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAE 215 +T +V TRWYRAPE++L +Y +++DIWS GCI AE Sbjct: 185 TNIVNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAE 244 Query: 216 LL-----------QGKALFPGS-----------------DYIDQLKRIMEVVGTPSPEVL 247 LL LFPGS DQL I ++GTP+ + L Sbjct: 245 LLNMLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDL 304 Query: 248 AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 I+ YI+ P +L + + I+LL ML + ++R++ +AL H Y Sbjct: 305 KNINKPEVIKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPY 364 Query: 308 FSQYHDPEDEPEAE-----PYDESVEAKERTLEEWKELTYQEVLSFKP 350 + E + P+D+ + E + + + +EV SF P Sbjct: 365 LKDVRKKKLENFSTKKIILPFDDWMVLSET---QLRYIFLKEVQSFHP 409 >3NIE-A nrPDB Length = 429 Score = 311 bits (798), Expect = 2e-85, Method: Composition-based stats. Identities = 132/410 (32%), Positives = 198/410 (48%), Gaps = 66/410 (16%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 61 S R Y Q +VP + +G G+YG V AYD + VA+KK++R F+ Sbjct: 8 SSGRENLYFQGAIIKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFED 67 Query: 62 LIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ- 120 LI +R RE+ +L LK + +I L D+ P ++ F E+Y+V + +DL + K Sbjct: 68 LIDCKRILREITILNRLKSDYIIRLHDLIIPEDLLK-FDELYIVLEIADSDLKKLFKTPI 126 Query: 121 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE-- 178 L+++HV+ ++Y LL G K+IH +GIIHRDLKP+N +N+DC ++I DFGLAR + + Sbjct: 127 FLTEQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKD 186 Query: 179 --------------------------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCI 212 +T +V TRWYRAPE++L +Y ++DIWS GCI Sbjct: 187 IHIVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCI 246 Query: 213 MAELL-----------QGKALFPGS-----------------DYIDQLKRIMEVVGTPSP 244 AELL LFPGS DQL I V+GTP Sbjct: 247 FAELLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPE 306 Query: 245 EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 E L I+ + YI+ P DLS + + IDLL ML ++ +R++ +AL+ Sbjct: 307 EDLKCITKQEVIKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALS 366 Query: 305 HAYFSQYHDPEDEPEAE-----PYDESVEAKERTLEEWKELTYQEVLSFK 349 H Y E + P+D+ + E + + + +E+ SF Sbjct: 367 HPYLKDVRKENLENFSTEKIILPFDDWMVLSET---QLRYIFLKEIQSFH 413 >3PG1-A nrPDB Length = 362 Score = 310 bits (795), Expect = 5e-85, Method: Composition-based stats. Identities = 121/340 (35%), Positives = 189/340 (55%), Gaps = 16/340 (4%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS---------LIHARRTYRELRL 74 R + SG+YG+VC+ D+ VA+K++ +R RE+RL Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 75 LKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQAL--SDEHVQFLVY 132 L H H N++GL D+F ++YLVT LM DL ++ Q + S +H+Q+ +Y Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPA-MHKLYLVTELMRTDLAQVIHDQRIVISPQHIQYFMY 141 Query: 133 QLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ--ADEEMTGYVATRWYRA 190 +L GL +H AG++HRDL P N+ + ++ ++ I DF LAR+ AD T YV RWYRA Sbjct: 142 HILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYRA 201 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI 250 PE+++ + + + VD+WS GC+MAE+ KALF GS + +QL +I+EVVGTP E + Sbjct: 202 PELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMF 261 Query: 251 SSEHARTYIQ-SLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 SS AR Y++ SL +P + +++ A+P+A+DL+ +ML + +R+S +AL H YF Sbjct: 262 SSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYFE 321 Query: 310 QYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFK 349 DP D E + + + ++ EV F Sbjct: 322 SLFDPLDLTEGLSERFHFDESVTDVYDMHKIFTAEVERFN 361 >6GU6-A nrPDB Length = 302 Score = 310 bits (795), Expect = 6e-85, Method: Composition-based stats. Identities = 100/297 (33%), Positives = 152/297 (51%), Gaps = 15/297 (5%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + + +G G YG V Q VA+KK+ + RE+ LLK L+H Sbjct: 7 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 66 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC----QALSDEHVQFLVYQLLRG 137 N++ L DV + S +YL+ + DL + Q + V+ +YQ+L+G Sbjct: 67 NIVSLQDV------LMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 120 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY---VATRWYRAPEIM 194 + + HS ++HRDLKP N+ +++ +++ DFGLAR + Y V T WYR+PE++ Sbjct: 121 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 180 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH 254 L Y+ VDIWS+G I AEL K LF G IDQL RI +GTP+ EV ++ E Sbjct: 181 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV--ES 238 Query: 255 ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 + Y + P L+S + + +DLL +ML+ D +R+S AL H YF+ Sbjct: 239 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 295 >3NCG-A nrPDB Length = 486 Score = 303 bits (776), Expect = 8e-83, Method: Composition-based stats. Identities = 94/346 (27%), Positives = 152/346 (43%), Gaps = 48/346 (13%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 61 S R Y Q +R + +G G++G V D +Q+ AVK +++ Sbjct: 8 SSGRENLYFQG------TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAK 61 Query: 62 LIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKC 119 RE+ LLK L H N++ L ++ +ED S Y+V L G + I+K Sbjct: 62 NKDTSTILREVELLKKLDHPNIMKLFEI------LEDSSSFYIVGELYTGGELFDEIIKR 115 Query: 120 QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAV---NEDCELRILDFGLAR--Q 174 + S+ ++ Q+ G+ Y+H I+HRDLKP N+ + +DC+++I+DFGL+ Q Sbjct: 116 KRFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQ 175 Query: 175 ADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKR 234 + +M + T +Y APE++ Y++ D+WS G I+ LL G F G + D LKR Sbjct: 176 QNTKMKDRIGTAYYIAPEVLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKR 233 Query: 235 IMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSD 294 + Y LP +R + A DL+ +ML Sbjct: 234 V------------------ETGKYAFDLPQ---------WRTISDDAKDLIRKMLTFHPS 266 Query: 295 QRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKEL 340 R++A + L H + +Y P ES R + K+L Sbjct: 267 LRITATQCLEHPWIQKYSSETPTISDLPSLESAMTNIRQFQAEKKL 312 >4AU8-A nrPDB Length = 296 Score = 302 bits (775), Expect = 1e-82, Method: Composition-based stats. Identities = 105/299 (35%), Positives = 154/299 (51%), Gaps = 14/299 (4%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 Q+ + L +G G YG+V A + + VA+K++ RE+ LLK LKH+ Sbjct: 6 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 65 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC--QALSDEHVQFLVYQLLRGLK 139 N++ L DV + ++ LV DL L E V+ ++QLL+GL Sbjct: 66 NIVRLHDV------LHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 119 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY---VATRWYRAPEIMLN 196 + HS ++HRDLKP N+ +N + EL++ DFGLAR + Y V T WYR P+++ Sbjct: 120 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 179 Query: 197 WMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 Y+ ++D+WS GCI AEL G+ LFPG+D DQLKRI ++GTP+ E ++ Sbjct: 180 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK--L 237 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 314 Y L ++ N DLL +L + QR+SA EAL H YFS + P Sbjct: 238 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 296 >4KRC-A nrPDB Length = 317 Score = 302 bits (773), Expect = 2e-82, Method: Composition-based stats. Identities = 97/306 (31%), Positives = 164/306 (53%), Gaps = 24/306 (7%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + + L +G+G Y +V + VA+K++ + RE+ L+K LKHE Sbjct: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGT-PSTAIREISLMKELKHE 63 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ-------ALSDEHVQFLVYQL 134 N++ L DV I +++ LV M DL + + L V++ +QL Sbjct: 64 NIVRLYDV------IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 Query: 135 LRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY---VATRWYRAP 191 L+GL + H I+HRDLKP N+ +N+ +L++ DFGLAR + + V T WYRAP Sbjct: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 ++++ Y+ ++DIWS GCI+AE++ GK LFPG++ +QLK I +++GTP+ + ++ Sbjct: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 Query: 252 SEHARTYIQSLPPMPQKDLSSIF-----RGANPLAIDLLGRMLVLDSDQRVSAAEALAHA 306 Y ++ P +DL + + +D L +L L+ D R+SA +AL H Sbjct: 238 K--LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 Query: 307 YFSQYH 312 +F++Y+ Sbjct: 296 WFAEYY 301 >1V0B-A nrPDB Length = 288 Score = 300 bits (769), Expect = 6e-82, Method: Composition-based stats. Identities = 105/294 (35%), Positives = 154/294 (52%), Gaps = 14/294 (4%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 ++ GL +G G YG V A + + A+KK+ + T RE+ +LK LKH Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELKHS 60 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--CQALSDEHVQFLVYQLLRGLK 139 N++ L DV I + LV + DL ++ L + + QLL G+ Sbjct: 61 NIVKLYDV------IHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIA 114 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY---VATRWYRAPEIMLN 196 Y H ++HRDLKP N+ +N + EL+I DFGLAR + Y V T WYRAP++++ Sbjct: 115 YCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMG 174 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHAR 256 Y+ T+DIWSVGCI AE++ G LFPG DQL RI ++GTP+ + ++ Sbjct: 175 SKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVT--ELP 232 Query: 257 TYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 Y + S +G + IDLL +ML LD +QR++A +AL HAYF + Sbjct: 233 KYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >3DFA-A nrPDB Length = 286 Score = 299 bits (767), Expect = 9e-82, Method: Composition-based stats. Identities = 88/317 (27%), Positives = 144/317 (45%), Gaps = 48/317 (15%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 61 S R Y Q +R + +G G++G V D +Q+ AVK +++ Sbjct: 8 SSGRENLYFQG------TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAK 61 Query: 62 LIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKC 119 RE+ LLK L H N++ L ++ +ED S Y+V L G + I+K Sbjct: 62 NKDTSTILREVELLKKLDHPNIMKLFEI------LEDSSSFYIVGELYTGGELFDEIIKR 115 Query: 120 QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAV---NEDCELRILDFGLAR--Q 174 + S+ ++ Q+ G+ Y+H I+HRDLKP N+ + +DC+++I+DFGL+ Q Sbjct: 116 KRFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQ 175 Query: 175 ADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKR 234 + +M + T +Y APE++ Y++ D+WS G I+ LL G F G + D LKR Sbjct: 176 QNTKMKDRIGTAYYIAPEVLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKR 233 Query: 235 IMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSD 294 + Y LP +R + A DL+ +ML Sbjct: 234 V------------------ETGKYAFDLPQ---------WRTISDDAKDLIRKMLTFHPS 266 Query: 295 QRVSAAEALAHAYFSQY 311 R++A + L H + +Y Sbjct: 267 LRITATQCLEHPWIQKY 283 >2I6L-A nrPDB Length = 320 Score = 296 bits (759), Expect = 9e-81, Method: Composition-based stats. Identities = 112/322 (34%), Positives = 184/322 (57%), Gaps = 18/322 (5%) Query: 12 ELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRE 71 +N +++ R L+P+G G G V SA D ++VA+KK+ + RE Sbjct: 1 SMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI--VLTDPQSVKHALRE 58 Query: 72 LRLLKHLKHENVIGLLDVFTPATS--------IEDFSEVYLVTTLMGADLNNIVKCQALS 123 +++++ L H+N++ + ++ P+ S + + + VY+V M DL N+++ L Sbjct: 59 IKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLL 118 Query: 124 DEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLARQADEEMTGY 182 +EH + +YQLLRGLKYIHSA ++HRDLKP+N+ +N ED L+I DFGLAR D + Sbjct: 119 EEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHK 178 Query: 183 ------VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 + T+WYR+P ++L+ +Y + +D+W+ GCI AE+L GK LF G+ ++Q++ I+ Sbjct: 179 GHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLIL 238 Query: 237 EVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQR 296 E + E ++ S YI++ P K L+ + G + A+D L ++L R Sbjct: 239 ESIPVVHEEDRQELLS-VIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDR 297 Query: 297 VSAAEALAHAYFSQYHDPEDEP 318 ++A EAL+H Y S Y P DEP Sbjct: 298 LTAEEALSHPYMSIYSFPMDEP 319 >5JN2-A nrPDB Length = 525 Score = 296 bits (757), Expect = 2e-80, Method: Composition-based stats. Identities = 87/316 (27%), Positives = 144/316 (45%), Gaps = 43/316 (13%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQSLIHARRTYRELRLLKHL 78 R +G R +G G++G V D Q+ AVK +S+ + RE++LLK L Sbjct: 65 FSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQL 124 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLR 136 H N++ L + F ED YLV + G + I+ + S+ ++ Q+L Sbjct: 125 DHPNIMKLYEFF------EDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLS 178 Query: 137 GLKYIHSAGIIHRDLKPSNVAV---NEDCELRILDFGLARQ--ADEEMTGYVATRWYRAP 191 G+ Y+H I+HRDLKP N+ + ++D +RI+DFGL+ A ++M + T +Y AP Sbjct: 179 GITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAP 238 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 E++ Y++ D+WS G I+ LL G F G++ D LK++ + T K+ Sbjct: 239 EVL--HGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKV- 295 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 + A DL+ +ML R+SA +AL H + Y Sbjct: 296 --------------------------SESAKDLIRKMLTYVPSMRISARDALDHEWIQTY 329 Query: 312 HDPEDEPEAEPYDESV 327 + + D ++ Sbjct: 330 TKEQISVDVPSLDNAI 345 >3DXN-A nrPDB Length = 287 Score = 295 bits (756), Expect = 2e-80, Method: Composition-based stats. Identities = 87/318 (27%), Positives = 141/318 (44%), Gaps = 50/318 (15%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQ 60 S R Y Q L+ R Q ++ +GSGAYG V D + A+K + + Sbjct: 8 SSGRENLYFQGLS-------DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVT 60 Query: 61 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVK 118 + ++ E+ +LK L H N++ L + F ED YLV + G + I+ Sbjct: 61 TTSNSGALLDEVAVLKQLDHPNIMKLYEFF------EDKRNYYLVMEVYRGGELFDEIIL 114 Query: 119 CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAV---NEDCELRILDFGLARQ- 174 Q S+ ++ Q+L G Y+H I+HRDLKP N+ + + D ++I+DFGL+ Sbjct: 115 RQKFSEVDAAVIMKQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHF 174 Query: 175 -ADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLK 233 +M + T +Y APE++ Y++ D+WS G I+ LL G F G + LK Sbjct: 175 EVGGKMKERLGTAYYIAPEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILK 232 Query: 234 RIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDS 293 R+ + + P ++S E A L+ ML + Sbjct: 233 RVEKGKFSFDPPDWTQVSDE---------------------------AKQLVKLMLTYEP 265 Query: 294 DQRVSAAEALAHAYFSQY 311 +R+SA EAL H + ++ Sbjct: 266 SKRISAEEALNHPWIVKF 283 >1UA2-A nrPDB Length = 346 Score = 295 bits (756), Expect = 2e-80, Method: Composition-based stats. Identities = 109/301 (36%), Positives = 160/301 (53%), Gaps = 17/301 (5%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH---ARRTYRELRLLKHL 78 +R + L +G G + +V A D Q VA+KK+ +S R RE++LL+ L Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQAL--SDEHVQFLVYQLLR 136 H N+IGLLD F ++I LV M DL I+K +L + H++ + L+ Sbjct: 70 SHPNIIGLLDAFGHKSNIS------LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE---MTGYVATRWYRAPEI 193 GL+Y+H I+HRDLKP+N+ ++E+ L++ DFGLA+ T V TRWYRAPE+ Sbjct: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSE 253 + Y VD+W+VGCI+AELL PG +DQL RI E +GTP+ E + S Sbjct: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 Query: 254 HARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHD 313 +S P +P L IF A +DL+ + + + R++A +AL YFS Sbjct: 244 PDYVTFKSFPGIP---LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 Query: 314 P 314 P Sbjct: 301 P 301 >3MA6-A nrPDB Length = 298 Score = 294 bits (754), Expect = 3e-80, Method: Composition-based stats. Identities = 91/326 (27%), Positives = 145/326 (44%), Gaps = 47/326 (14%) Query: 2 SGPRAGFYRQELNKTVWE----VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR 57 S R Y Q V R +G R +G G++G V D Q+ AVK +S+ Sbjct: 8 SSGRENLYFQGPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISK 67 Query: 58 P-FQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLN 114 + RE++LLK L H N++ L + F ED YLV + G + Sbjct: 68 RQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFF------EDKGYFYLVGEVYTGGELFD 121 Query: 115 NIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAV---NEDCELRILDFGL 171 I+ + S+ ++ Q+L G+ Y+H I+HRDLKP N+ + ++D +RI+DFGL Sbjct: 122 EIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGL 181 Query: 172 ARQ--ADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYI 229 + A ++M + T +Y APE++ Y++ D+WS G I+ LL G F G++ Sbjct: 182 STHFEASKKMKDKIGTAYYIAPEVL--HGTYDEKCDVWSTGVILYILLSGCPPFNGANEY 239 Query: 230 DQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRML 289 D LK++ + T K+ + A DL+ +ML Sbjct: 240 DILKKVEKGKYTFELPQWKKV---------------------------SESAKDLIRKML 272 Query: 290 VLDSDQRVSAAEALAHAYFSQYHDPE 315 R+SA +AL H + Y + Sbjct: 273 TYVPSMRISARDALDHEWIQTYTKEQ 298 >4AGU-A nrPDB Length = 311 Score = 293 bits (750), Expect = 9e-80, Method: Composition-based stats. Identities = 87/300 (29%), Positives = 147/300 (49%), Gaps = 11/300 (3%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 ++ + + +G G+YG V + Q VA+KK + + RE+R+LK LKH Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC--QALSDEHVQFLVYQLLRGLK 139 N++ LL+VF + LV + + + + + + V+ + +Q L+ + Sbjct: 63 NLVNLLEVFRRKRRLH------LVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVN 116 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY---VATRWYRAPEIMLN 196 + H IHRD+KP N+ + + +++ DFG AR Y VATRWYR+PE+++ Sbjct: 117 FCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVG 176 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHAR 256 Y VD+W++GC+ AELL G L+PG +DQL I + +G P S+ Sbjct: 177 DTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYF 236 Query: 257 TYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPED 316 + ++ P + L F + A+ LL L +D +R++ + L H YF + ED Sbjct: 237 SGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIREIED 296 >5EFQ-A nrPDB Length = 347 Score = 291 bits (746), Expect = 2e-79, Method: Composition-based stats. Identities = 90/312 (28%), Positives = 146/312 (46%), Gaps = 11/312 (3%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + + +G G YG V A D + VA+KK+ + RE+++L+ L H+ Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 82 NVIGLLDVFTPATSIEDFSE----VYLVTTLMGADLNNIVKCQ--ALSDEHVQFLVYQLL 135 ++I + ++ T DF + YLV M DL +++ ++ H++ + QL+ Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 130 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE----MTGYVATRWYRAP 191 GL Y H +HRD+K SN+ +N ++++ DFGLAR E T V T WYR P Sbjct: 131 EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 190 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 E++L Y +D+WS GCI+ EL K +F + + QL+ I + G+P P V + Sbjct: 191 ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVI 250 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 ++ +K L F A+DL ML LD +R +A +AL + Sbjct: 251 KLPYFNTMKPKKQYRRK-LREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDV 309 Query: 312 HDPEDEPEAEPY 323 + P P Sbjct: 310 EPSKMPPPDLPL 321 >3LIJ-A nrPDB Length = 494 Score = 291 bits (746), Expect = 3e-79, Method: Composition-based stats. Identities = 84/325 (25%), Positives = 143/325 (44%), Gaps = 51/325 (15%) Query: 2 SGPRAGFYRQE---------LNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAV 52 S R Y Q + + + Q ++ +GSGAYG V D + A+ Sbjct: 8 SSGRENLYFQGDLQATPGMFITSKKGHLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAI 67 Query: 53 KKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--G 110 K + + S + E+ +LK L H N++ L D F ED YLV G Sbjct: 68 KIIRKTSVSTSSNSKLLEEVAVLKLLDHPNIMKLYDFF------EDKRNYYLVMECYKGG 121 Query: 111 ADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN---EDCELRIL 167 + I+ ++ ++ Q+L G+ Y+H I+HRDLKP N+ + +D ++I+ Sbjct: 122 ELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIV 181 Query: 168 DFGLAR--QADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG 225 DFGL+ + ++M + T +Y APE++ Y++ D+WS+G I+ LL G F G Sbjct: 182 DFGLSAVFENQKKMKERLGTAYYIAPEVL--RKKYDEKCDVWSIGVILFILLAGYPPFGG 239 Query: 226 SDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLL 285 + L+++ + T S ++ + A DL+ Sbjct: 240 QTDQEILRKVEKGKYTFD---------------------------SPEWKNVSEGAKDLI 272 Query: 286 GRMLVLDSDQRVSAAEALAHAYFSQ 310 +ML DS +R+SA +AL H + + Sbjct: 273 KQMLQFDSQRRISAQQALEHPWIKE 297 >4NST-A nrPDB Length = 351 Score = 291 bits (744), Expect = 5e-79, Method: Composition-based stats. Identities = 96/341 (28%), Positives = 159/341 (46%), Gaps = 15/341 (4%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + + +G G YG V A D + VA+KK+ + RE+++L+ L H Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR 72 Query: 82 NVIGLLDVFTPATSIEDFSE----VYLVTTLMGADLNNIVKCQ--ALSDEHVQFLVYQLL 135 +V+ + ++ T DF + YLV M DL +++ S++H++ + QL+ Sbjct: 73 SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLM 132 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE----MTGYVATRWYRAP 191 GL+Y H +HRD+K SN+ +N ++++ DFGLAR + E T V T WYR P Sbjct: 133 EGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPP 192 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 E++L Y +D+WS GCI+ EL K +F + + QL+ I + G+P P V + Sbjct: 193 ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVI 252 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 ++ ++ L F A+DLL ML LD +R +A + L + Sbjct: 253 KLPYFNTMKPKKQY-RRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLK-- 309 Query: 312 HDPEDEPEAEP-YDESVEAKERTLEEWKELTYQEVLSFKPP 351 D E A P + E ++ + V+ +PP Sbjct: 310 -DVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPP 349 >4BBM-A nrPDB Length = 331 Score = 290 bits (742), Expect = 7e-79, Method: Composition-based stats. Identities = 93/311 (29%), Positives = 153/311 (49%), Gaps = 19/311 (6%) Query: 4 PRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLI 63 Y Q + ++ + L VG G+YG V + + VA+KK + Sbjct: 15 GTENLYFQSM--------EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKM 66 Query: 64 HARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--CQA 121 + RE++LLK L+HEN++ LL+V YLV + + + ++ Sbjct: 67 VKKIAMREIKLLKQLRHENLVNLLEVCKKK------KRWYLVFEFVDHTILDDLELFPNG 120 Query: 122 LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA---DEE 178 L + VQ ++Q++ G+ + HS IIHRD+KP N+ V++ +++ DFG AR E Sbjct: 121 LDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEV 180 Query: 179 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 238 VATRWYRAPE+++ + Y + VD+W++GC++ E+ G+ LFPG IDQL IM Sbjct: 181 YDDEVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMC 240 Query: 239 VGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS 298 +G P + ++ ++ L + + + IDL + L +D D+R Sbjct: 241 LGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPF 300 Query: 299 AAEALAHAYFS 309 AE L H +F Sbjct: 301 CAELLHHDFFQ 311 >3HZT-A nrPDB Length = 467 Score = 289 bits (741), Expect = 1e-78, Method: Composition-based stats. Identities = 82/300 (27%), Positives = 136/300 (45%), Gaps = 43/300 (14%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQSLIHARRTYRELRLLKHL 78 + R Q ++ +GSGAYG V D + A+K + + + ++ E+ +LK L Sbjct: 2 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 61 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLR 136 H N++ L + F ED YLV + G + I+ Q S+ ++ Q+L Sbjct: 62 DHPNIMKLYEFF------EDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLS 115 Query: 137 GLKYIHSAGIIHRDLKPSNVAV---NEDCELRILDFGLARQ--ADEEMTGYVATRWYRAP 191 G Y+H I+HRDLKP N+ + + D ++I+DFGL+ +M + T +Y AP Sbjct: 116 GTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAP 175 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 E++ Y++ D+WS G I+ LL G F G + LKR+ + + P ++S Sbjct: 176 EVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVS 233 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 E A L+ ML + +R+SA EAL H + ++ Sbjct: 234 DE---------------------------AKQLVKLMLTYEPSKRISAEEALNHPWIVKF 266 >3MIA-A nrPDB Length = 351 Score = 286 bits (731), Expect = 1e-77, Method: Composition-based stats. Identities = 93/306 (30%), Positives = 153/306 (50%), Gaps = 14/306 (4%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + + L +G G +G V A + QKVA+KK+ + RE+++L+ LKHE Sbjct: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 Query: 82 NVIGLLDVFTPATSIEDFSE--VYLVTTLMGADLNNIVKCQ--ALSDEHVQFLVYQLLRG 137 NV+ L+++ S + + +YLV DL ++ + ++ ++ LL G Sbjct: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD-------EEMTGYVATRWYRA 190 L YIH I+HRD+K +NV + D L++ DFGLAR T V T WYR Sbjct: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI 250 PE++L Y +D+W GCIMAE+ + G+ QL I ++ G+ +PEV + Sbjct: 197 PELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNV 256 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGA-NPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 + ++ + +K + +P A+DL+ ++LVLD QR+ + +AL H +F Sbjct: 257 DNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF- 315 Query: 310 QYHDPE 315 + DP Sbjct: 316 -WSDPM 320 >1G3N-A nrPDB Length = 326 Score = 284 bits (728), Expect = 3e-77, Method: Composition-based stats. Identities = 101/299 (33%), Positives = 160/299 (53%), Gaps = 15/299 (5%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQK-VAVKKLSRPFQSLIHARRTYRELRLLKHLK- 79 Q+ + + +G GAYG V A D + + VA+K++ T RE+ +L+HL+ Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 80 --HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC---QALSDEHVQFLVYQL 134 H NV+ L DV T + + + +++ LV + DL + + E ++ +++QL Sbjct: 71 FEHPNVVRLFDVCTVSRTDRE-TKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 135 LRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM--TGYVATRWYRAPE 192 LRGL ++HS ++HRDLKP N+ V ++++ DFGLAR +M T V T WYRAPE Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 ++L Y VD+WSVGCI AE+ + K LF GS +DQL +I++V+G P E + + Sbjct: 190 VLL-QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 Query: 253 EHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 Q+ + + + L DLL + L + +R+SA AL+H YF Sbjct: 249 LP----RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 >5AIR-A nrPDB Length = 430 Score = 284 bits (726), Expect = 5e-77, Method: Composition-based stats. Identities = 97/301 (32%), Positives = 159/301 (52%), Gaps = 18/301 (5%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 + +G+G++G V A + VA+KK+ L R REL++++ L H N+ Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV------LQDKRFKNRELQIMRKLDHCNI 119 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-----QALSDEHVQFLVYQLLRGL 138 + L F + +D + LV + + + + Q L +V+ +YQL R L Sbjct: 120 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 179 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDC-ELRILDFGLARQA--DEEMTGYVATRWYRAPEIML 195 YIHS GI HRD+KP N+ ++ D L++ DFG A+Q E Y+ +R+YRAPE++ Sbjct: 180 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 239 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 Y ++D+WS GC++AELL G+ +FPG +DQL I++V+GTP+ E + +++ + Sbjct: 240 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYT 299 Query: 256 RTYIQSLPPMPQKDLSSIFRGAN-PLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 314 P + + +FR P AI L R+L R++ EA AH++F + DP Sbjct: 300 EF---KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 356 Query: 315 E 315 Sbjct: 357 N 357 >4MVF-A nrPDB Length = 506 Score = 281 bits (718), Expect = 5e-76, Method: Composition-based stats. Identities = 75/298 (25%), Positives = 135/298 (45%), Gaps = 44/298 (14%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 + + +G G YG V D Q A+K+ + L + R ++E+ ++K L Sbjct: 55 LEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKD--RLKNINRFFQEIEIMKKLD 112 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLMGA--DLNNIVKCQALSDEHVQFLVYQLLRG 137 H N++ L + + E+ + +YL+ L ++I++ + ++++ ++ Q+ Sbjct: 113 HPNIVKLYETY------ENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSA 166 Query: 138 LKYIHSAGIIHRDLKPSNVAV---NEDCELRILDFGLARQA--DEEMTGYVATRWYRAPE 192 + Y+HS I+HRDLKP N N+D L+I+DFGL++ E T T +Y AP+ Sbjct: 167 IFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQ 226 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 ++ Y++ DIWS G IM LL G F G + LK++ + ISS Sbjct: 227 VLDG--KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISS 284 Query: 253 EHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 A +L+ ++L + ++R + EAL H + +Q Sbjct: 285 ---------------------------DAKNLITKLLTYNPNERCTIEEALNHPWITQ 315 >5Y86-A nrPDB Length = 588 Score = 280 bits (716), Expect = 8e-76, Method: Composition-based stats. Identities = 107/348 (30%), Positives = 173/348 (49%), Gaps = 43/348 (12%) Query: 1 MSGPRAGFYRQELNKTVWEVPQ-----RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKL 55 + GP G Y + + VP+ R + L+ +G G++G V YD +LRQ VA+K + Sbjct: 182 IGGPNNGGY-DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV 240 Query: 56 SRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNN 115 + R+ E+R+L+HLK ++ G ++V S + V + L+ DL Sbjct: 241 RNEKR---FHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYE 297 Query: 116 IVKC---QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE--LRILDFG 170 ++K Q S + V+ +L+ L +H IIH DLKP N+ + +++DFG Sbjct: 298 LIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG 357 Query: 171 LARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID 230 + +++ Y+ +R+YRAPEI+L Y+ +DIWS GCI+AELL G+ LFPG D D Sbjct: 358 SSCFEYQKLYTYIQSRFYRAPEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGD 416 Query: 231 QLKRIMEVVGTPSPEVLAK-------ISSEHARTYI--------------------QSLP 263 QL +ME++G P P++L + I+S+ Y + Sbjct: 417 QLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRG 476 Query: 264 PMPQKDLSSIFRGANP-LAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 P KD + +G + L I+ L R L D R++ A+AL H + S+ Sbjct: 477 PPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISK 524 >3Q5I-A nrPDB Length = 504 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 88/336 (26%), Positives = 136/336 (40%), Gaps = 61/336 (18%) Query: 2 SGPRAGFYRQELN--------KTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVK 53 S R Y Q + K ++ + +R +GSGAYG V + + A+K Sbjct: 8 SSGRENLYFQGIAINPGMYVRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIK 67 Query: 54 KLSRPFQSLIH-----------ARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEV 102 + + Y E+ LLK L H N+I L DVF ED Sbjct: 68 VIKKSQFDKGRYSDDNKNIEKFHEEIYNEISLLKSLDHPNIIKLFDVF------EDKKYF 121 Query: 103 YLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNE 160 YLVT G I+ + ++ Q+L G+ Y+H I+HRD+KP N+ + Sbjct: 122 YLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLEN 181 Query: 161 DC---ELRILDFGLARQA--DEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAE 215 ++I+DFGL+ D ++ + T +Y APE++ YN+ D+WS G IM Sbjct: 182 KNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYYIAPEVL--KKKYNEKCDVWSCGVIMYI 239 Query: 216 LLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFR 275 LL G F G + D +K++ + IS E Sbjct: 240 LLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISDE---------------------- 277 Query: 276 GANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 A +L+ ML D ++R +A EAL + +Y Sbjct: 278 -----AKELIKLMLTYDYNKRCTAEEALNSRWIKKY 308 >5G6V-A nrPDB Length = 324 Score = 275 bits (703), Expect = 2e-74, Method: Composition-based stats. Identities = 98/293 (33%), Positives = 147/293 (50%), Gaps = 15/293 (5%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + L +G G Y +V VA+K++ + RE+ LLK LKH Sbjct: 2 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPC-TAIREVSLLKDLKHA 60 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA--LSDEHVQFLVYQLLRGLK 139 N++ L D+ I + LV + DL + ++ +V+ ++QLLRGL Sbjct: 61 NIVTLHDI------IHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLA 114 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY---VATRWYRAPEIMLN 196 Y H ++HRDLKP N+ +NE EL++ DFGLAR Y V T WYR P+I+L Sbjct: 115 YCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLG 174 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI-SSEHA 255 Y+ +D+W VGCI E+ G+ LFPGS +QL I ++GTP+ E I S+E Sbjct: 175 STDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEF 234 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 +TY + P + L S + DLL ++L + R+SA +A+ H +F Sbjct: 235 KTY--NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >2W96-B nrPDB Length = 306 Score = 275 bits (703), Expect = 2e-74, Method: Composition-based stats. Identities = 104/306 (33%), Positives = 153/306 (50%), Gaps = 17/306 (5%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK-- 79 R + + +G GAYG+V A D VA+K + P T RE+ LL+ L+ Sbjct: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAF 63 Query: 80 -HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC---QALSDEHVQFLVYQLL 135 H NV+ L+DV + + + +V LV + DL + L E ++ L+ Q L Sbjct: 64 EHPNVVRLMDVCATSRTDREI-KVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 122 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT--GYVATRWYRAPEI 193 RGL ++H+ I+HRDLKP N+ V +++ DFGLAR +M V T WYRAPE+ Sbjct: 123 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEV 182 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSE 253 +L Y VD+WSVGCI AE+ + K LF G+ DQL +I +++G P + + S Sbjct: 183 LLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 241 Query: 254 HARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHD 313 + PP + + S+ LL ML + +R+SA AL H+Y H Sbjct: 242 P----RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL---HK 294 Query: 314 PEDEPE 319 E PE Sbjct: 295 DEGNPE 300 >4RGJ-A nrPDB Length = 520 Score = 275 bits (703), Expect = 2e-74, Method: Composition-based stats. Identities = 87/317 (27%), Positives = 146/317 (46%), Gaps = 47/317 (14%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQ 60 S R G + Q N ++ +G++ +G G++G V + D + A+K +S+ + Sbjct: 43 SKLRPGMFIQNSNVV---FNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVK 99 Query: 61 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVK 118 RE+ LLK L H N++ L + F ED + YLV+ + G + I+ Sbjct: 100 RKTDKESLLREVELLKMLDHINIMKLYEFF------EDNNYYYLVSDVYTGGELFDEIIS 153 Query: 119 CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN----EDCELRILDFGLARQ 174 + + ++ Q+L G+ Y+H ++HRDLKP N+ + ED ++I+DFGL+ Sbjct: 154 RKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTH 213 Query: 175 A--DEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQL 232 ++M + T +Y AP+++ Y++ DIWS G I+ LL G F GS+ D L Sbjct: 214 FEYSKKMKDKIGTAYYIAPDVL--HGTYDEKCDIWSCGVILYILLSGCPPFNGSNEYDIL 271 Query: 233 KRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLD 292 K++ T KIS + A DL+ +ML+ Sbjct: 272 KKVEAGKYTFDLPQFKKISDK---------------------------AKDLIKKMLMYT 304 Query: 293 SDQRVSAAEALAHAYFS 309 S R+SA +AL H + Sbjct: 305 SAVRISARDALEHEWIK 321 >2VN9-A nrPDB Length = 301 Score = 274 bits (702), Expect = 3e-74, Method: Composition-based stats. Identities = 79/300 (26%), Positives = 129/300 (43%), Gaps = 44/300 (14%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 + Q +G GA+ V Q+ A K ++ S ++ RE R+ + LK Sbjct: 2 MTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLK 61 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRG 137 H N++ L D SI + YLV L+ G +IV + S+ + Q+L Sbjct: 62 HPNIVRLHD------SISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILES 115 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCE---LRILDFGLARQADEEMT---GYVATRWYRAP 191 + + H GI+HRDLKP N+ + + +++ DFGLA + + G+ T Y +P Sbjct: 116 VNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSP 175 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV-VGTPSPEVLAKI 250 E++ Y + VD+W+ G I+ LL G F D ++I PSPE Sbjct: 176 EVLRKD-PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPE----- 229 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + P A DL+ +ML ++ +R++A+EAL H + Q Sbjct: 230 -----------------------WDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQ 266 >2V7O-A nrPDB Length = 336 Score = 274 bits (700), Expect = 6e-74, Method: Composition-based stats. Identities = 82/316 (25%), Positives = 132/316 (41%), Gaps = 45/316 (14%) Query: 4 PRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLI 63 Y Q + Q +G GA+ V Q+ A K ++ S Sbjct: 14 GTENLYFQSMATCT-RFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSAR 72 Query: 64 HARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQA 121 ++ RE R+ + LKH N++ L D SI + YLV L+ G +IV + Sbjct: 73 DHQKLEREARICRLLKHPNIVRLHD------SISEEGFHYLVFDLVTGGELFEDIVAREY 126 Query: 122 LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE---LRILDFGLARQADEE 178 S+ ++Q+L + +IH I+HRDLKP N+ + C+ +++ DFGLA + E Sbjct: 127 YSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGE 186 Query: 179 MT---GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRI 235 G+ T Y +PE++ Y + VDIW+ G I+ LL G F D ++I Sbjct: 187 QQAWFGFAGTPGYLSPEVLRKD-PYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI 245 Query: 236 MEV-VGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSD 294 PSPE + P A +L+ +ML ++ Sbjct: 246 KAGAYDFPSPE----------------------------WDTVTPEAKNLINQMLTINPA 277 Query: 295 QRVSAAEALAHAYFSQ 310 +R++A +AL H + Q Sbjct: 278 KRITADQALKHPWVCQ 293 >5U6Y-A nrPDB Length = 461 Score = 274 bits (700), Expect = 6e-74, Method: Composition-based stats. Identities = 79/296 (26%), Positives = 129/296 (43%), Gaps = 44/296 (14%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 Q +G GA+ V Q+ A K ++ S ++ RE R+ + LKH N+ Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYI 141 + L D SI + YL+ L+ G +IV + S+ + Q+L + + Sbjct: 62 VRLHD------SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 115 Query: 142 HSAGIIHRDLKPSNVAVNEDCE---LRILDFGLARQADEEMT---GYVATRWYRAPEIML 195 H G++HRDLKP N+ + + +++ DFGLA + + E G+ T Y +PE++ Sbjct: 116 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR 175 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV-VGTPSPEVLAKISSEH 254 Y + VD+W+ G I+ LL G F D ++I PSPE Sbjct: 176 KD-PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPE--------- 225 Query: 255 ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + P A DL+ +ML ++ +R++AAEAL H + S Sbjct: 226 -------------------WDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISH 262 >2VZ6-A nrPDB Length = 313 Score = 273 bits (699), Expect = 7e-74, Method: Composition-based stats. Identities = 81/316 (25%), Positives = 132/316 (41%), Gaps = 54/316 (17%) Query: 4 PRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLI 63 Y Q + Q +G GA+ V Q+ A K ++ S Sbjct: 14 GTENLYFQSM----------YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSAR 63 Query: 64 HARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQA 121 ++ RE R+ + LKH N++ L D SI + YL+ L+ G +IV + Sbjct: 64 DHQKLEREARICRLLKHPNIVRLHD------SISEEGHHYLIFDLVTGGELFEDIVAREY 117 Query: 122 LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE---LRILDFGLARQADEE 178 S+ + Q+L + + H G++HRDLKP N+ + + +++ DFGLA + + E Sbjct: 118 YSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGE 177 Query: 179 MT---GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRI 235 G+ T Y +PE++ Y + VD+W+ G I+ LL G F D ++I Sbjct: 178 QQAWFGFAGTPGYLSPEVLRKD-PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI 236 Query: 236 MEV-VGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSD 294 PSPE + P A DL+ +ML ++ Sbjct: 237 KAGAYDFPSPE----------------------------WDTVTPEAKDLINKMLTINPS 268 Query: 295 QRVSAAEALAHAYFSQ 310 +R++AAEAL H + S Sbjct: 269 KRITAAEALKHPWISH 284 >5FG8-A nrPDB Length = 285 Score = 272 bits (697), Expect = 1e-73, Method: Composition-based stats. Identities = 75/300 (25%), Positives = 128/300 (42%), Gaps = 44/300 (14%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 +G GA+ V + A K ++ + ++ RE R+ + L Sbjct: 12 FSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLH 71 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRG 137 H N++ L D SI++ + YLV L+ G +IV + S+ + Q+L Sbjct: 72 HPNIVRLHD------SIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILES 125 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCE---LRILDFGLARQADEEMT---GYVATRWYRAP 191 + + H G++HRDLKP N+ + + +++ DFGLA + + G+ T Y +P Sbjct: 126 VNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSP 185 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV-VGTPSPEVLAKI 250 E++ Y ++VDIW+ G I+ LL G F D +I PSPE Sbjct: 186 EVL-KKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPE----- 239 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + P A +L+ +ML ++ ++R++AAEAL H + Q Sbjct: 240 -----------------------WDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQ 276 >4YZB-A nrPDB Length = 491 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 87/327 (26%), Positives = 146/327 (44%), Gaps = 47/327 (14%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQSLIHARRTYRELRLLKHL 78 R +G R +G G++G V D Q+ AVK +S+ + +E+ LLK L Sbjct: 28 FSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKL 87 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLR 136 H N++ L + F ED YLVT + G + I+ + S+ ++ Q+L Sbjct: 88 DHPNIMKLYEFF------EDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLS 141 Query: 137 GLKYIHSAGIIHRDLKPSNVAVN---EDCELRILDFGLARQADE--EMTGYVATRWYRAP 191 G+ Y+H I+HRDLKP N+ + +D +RI+DFGL+ + +M + T +Y AP Sbjct: 142 GITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAP 201 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 E++ Y++ D+WS G I+ LL G F G++ D LK++ + T K+ Sbjct: 202 EVL--HGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKV- 258 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 + A DL+ +ML R+SA +AL H + Sbjct: 259 --------------------------SEPAKDLIRKMLAYVPTMRISARDALEHEWLKTT 292 Query: 312 HDPEDEPEAEPYDESVEAKERTLEEWK 338 D + S+E+ + +++ Sbjct: 293 DAATDSIDVP----SLESTILNIRQFQ 315 >4CFF-A nrPDB Length = 571 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 88/333 (26%), Positives = 136/333 (40%), Gaps = 46/333 (13%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKHE 81 +G G +G V KVAVK L+R +SL + RE++ LK +H Sbjct: 34 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 93 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV-KCQALSDEHVQFLVYQLLRGLK 139 ++I L V + T + ++V + G +L + + K + + + L Q+L + Sbjct: 94 HIIKLYQVISTPT------DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 147 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--DEEMTGYVATRWYRAPEIMLNW 197 Y H ++HRDLKP NV ++ +I DFGL+ E + + Y APE++ Sbjct: 148 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 207 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257 ++ VDIWS G I+ LL G F K+I V PE L Sbjct: 208 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY-IPEYL---------- 256 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDE 317 N LL ML +D +R + + H +F Q Sbjct: 257 --------------------NRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLF 296 Query: 318 PEAEPYDESV---EAKERTLEEWKELTYQEVLS 347 PE YD +V EA + E++ E T EV++ Sbjct: 297 PEDPSYDANVIDDEAVKEVCEKF-ECTESEVMN 328 >3MN3-A nrPDB Length = 271 Score = 271 bits (694), Expect = 3e-73, Method: Composition-based stats. Identities = 72/300 (24%), Positives = 130/300 (43%), Gaps = 41/300 (13%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR-RTYRELRLLKHLKHE 81 Q ++ +G G++G V AY QKVA+K +++ + + R RE+ L+ L+H Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHP 64 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV-KCQALSDEHVQFLVYQLLRGLKY 140 ++I L DV I+ E+ +V G +L + + + +S++ + Q++ ++Y Sbjct: 65 HIIKLYDV------IKSKDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEY 118 Query: 141 IHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE--EMTGYVATRWYRAPEIMLNWM 198 H I+HRDLKP N+ ++E ++I DFGL+ + + + Y APE++ + Sbjct: 119 CHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKL 178 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 + VD+WS G I+ +L + F K I V T Sbjct: 179 YAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLP--------------- 223 Query: 259 IQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEP 318 + +P A L+ RML+++ R+S E + +F P Sbjct: 224 ----------------KFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFKVDLPEYLLP 267 >4REW-A nrPDB Length = 540 Score = 271 bits (693), Expect = 4e-73, Method: Composition-based stats. Identities = 90/334 (26%), Positives = 140/334 (41%), Gaps = 48/334 (14%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKHE 81 +G G +G V KVAVK L+R +SL + RE++ LK +H Sbjct: 7 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 66 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV-KCQALSDEHVQFLVYQLLRGLK 139 ++I L V + S++++V + G +L + + K L ++ + L Q+L G+ Sbjct: 67 HIIKLYQVISTP------SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 120 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--DEEMTGYVATRWYRAPEIMLNW 197 Y H ++HRDLKP NV ++ +I DFGL+ E + + Y APE++ Sbjct: 121 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 180 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257 ++ VDIWS G I+ LL G F K+I + + Sbjct: 181 LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTP-------------- 226 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ----YHD 313 + NP I LL ML +D +R S + H +F Q Y Sbjct: 227 -----------------QYLNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYLF 269 Query: 314 PEDEPEAEPYDESVEAKERTLEEWKELTYQEVLS 347 PED P EA + E++ E + +EVLS Sbjct: 270 PED-PSYSSTMIDDEALKEVCEKF-ECSEEEVLS 301 >5EZV-A nrPDB Length = 560 Score = 271 bits (692), Expect = 4e-73, Method: Composition-based stats. Identities = 88/333 (26%), Positives = 136/333 (40%), Gaps = 46/333 (13%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKHE 81 +G G +G V KVAVK L+R +SL + RE++ LK +H Sbjct: 29 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 88 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV-KCQALSDEHVQFLVYQLLRGLK 139 ++I L V + T + ++V + G +L + + K + + + L Q+L + Sbjct: 89 HIIKLYQVISTPT------DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 142 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--DEEMTGYVATRWYRAPEIMLNW 197 Y H ++HRDLKP NV ++ +I DFGL+ E + + Y APE++ Sbjct: 143 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 202 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257 ++ VDIWS G I+ LL G F K+I V PE L Sbjct: 203 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY-IPEYL---------- 251 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDE 317 N LL ML +D +R + + H +F Q Sbjct: 252 --------------------NRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLF 291 Query: 318 PEAEPYDESV---EAKERTLEEWKELTYQEVLS 347 PE YD +V EA + E++ E T EV++ Sbjct: 292 PEDPSYDANVIDDEAVKEVCEKF-ECTESEVMN 323 >3ZDU-A nrPDB Length = 325 Score = 271 bits (692), Expect = 5e-73, Method: Composition-based stats. Identities = 89/292 (30%), Positives = 145/292 (49%), Gaps = 12/292 (4%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 + L VG G+YG+V Q VA+K + ++ + RE++ LK HEN+ Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVN-KIAMREIKFLKQFHHENL 63 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGAD-LNNIVK-CQALSDEHVQFLVYQLLRGLKYI 141 + L++VF I LV + L+ + C L + ++ ++Q+LR + Y+ Sbjct: 64 VNLIEVFRQKKKIH------LVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYL 117 Query: 142 HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYRAPEIMLNWM 198 HS IIHRD+KP N+ V++ ++ DFG AR + VATRWYRAPE++L Sbjct: 118 HSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDT 177 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 Y + VDIW++GC++ E+ G P S +D L +I+ VG SP + S Sbjct: 178 SYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAG 237 Query: 259 IQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + K+ + N L D++ L +D R+S+++ L H YF++ Sbjct: 238 VVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTR 289 >2JDO-A nrPDB Length = 342 Score = 270 bits (691), Expect = 6e-73, Method: Composition-based stats. Identities = 79/357 (22%), Positives = 145/357 (40%), Gaps = 54/357 (15%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQSLIHARRTYRELRLLKHLKH 80 L+ +G G +G V + + A+K L + + T E R+L++ +H Sbjct: 10 NDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRH 69 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGL 138 + L F + V G ++ + + ++E +F +++ L Sbjct: 70 PFLTALKYAFQTH------DRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSAL 123 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYRAPEIML 195 +Y+HS +++RD+K N+ +++D ++I DFGL ++ M + T Y APE++ Sbjct: 124 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 183 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRI-MEVVGTPSPEVLAKISSEH 254 + Y + VD W +G +M E++ G+ F D+ + I ME + P Sbjct: 184 DN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFP------------ 230 Query: 255 ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEALAHAYFS 309 R +P A LL +L D QR+ A E + H +F Sbjct: 231 --------------------RTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFL 270 Query: 310 --QYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSLEIEQ 364 + D + P+ V ++ T E T Q + + PP+ G LE++Q Sbjct: 271 SINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSI-TITPPDRYDSLGLLELDQ 326 >2BDW-A nrPDB Length = 362 Score = 269 bits (688), Expect = 1e-72, Method: Composition-based stats. Identities = 75/299 (25%), Positives = 125/299 (41%), Gaps = 43/299 (14%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 +G GA+ V + A K ++ S ++ RE R+ + L+ Sbjct: 27 FSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQ 86 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRG 137 H N++ L D SI++ S YLV L+ G +IV + S+ + Q+L Sbjct: 87 HPNIVRLHD------SIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILES 140 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCE---LRILDFGLARQADEE--MTGYVATRWYRAPE 192 + Y HS GI+HR+LKP N+ + + +++ DFGLA + ++ G+ T Y +PE Sbjct: 141 IAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPE 200 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV-VGTPSPEVLAKIS 251 ++ Y++ VDIW+ G I+ LL G F D +I PSPE Sbjct: 201 VLKKD-PYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPE------ 253 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + P A L+ ML ++ +R++A +AL + Sbjct: 254 ----------------------WDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICN 290 >3SOA-A nrPDB Length = 444 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 77/300 (25%), Positives = 129/300 (43%), Gaps = 44/300 (14%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 + Q +G GA+ V Q+ A ++ S ++ RE R+ + LK Sbjct: 9 FTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLK 68 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRG 137 H N++ L D SI + YL+ L+ G +IV + S+ + Q+L Sbjct: 69 HPNIVRLHD------SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEA 122 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCE---LRILDFGLARQADEEMT---GYVATRWYRAP 191 + + H G++HR+LKP N+ + + +++ DFGLA + + E G+ T Y +P Sbjct: 123 VLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSP 182 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV-VGTPSPEVLAKI 250 E++ Y + VD+W+ G I+ LL G F D ++I PSPE Sbjct: 183 EVLRKD-PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPE----- 236 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + P A DL+ +ML ++ +R++AAEAL H + S Sbjct: 237 -----------------------WDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISH 273 >4E7W-A nrPDB Length = 394 Score = 268 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 103/301 (34%), Positives = 159/301 (52%), Gaps = 19/301 (6%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 + +G+G++G V A + VA+KK+ L R REL++++ +KH NV Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKV------LQDKRFKNRELQIMRIVKHPNV 94 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-----QALSDEHVQFLVYQLLRGL 138 + L F +D + LV + + + Q + ++ +YQLLR L Sbjct: 95 VDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSL 154 Query: 139 KYIHSAGIIHRDLKPSNVAVNE-DCELRILDFGLARQA--DEEMTGYVATRWYRAPEIML 195 YIHS GI HRD+KP N+ ++ L+++DFG A+ E Y+ +R+YRAPE++ Sbjct: 155 AYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIF 214 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 +Y +DIWS GC+MAEL+QG+ LFPG IDQL I++V+GTPS E + ++ + Sbjct: 215 GATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYM 274 Query: 256 RTYIQSLPPMPQKDLSSIFRGAN-PLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 314 + P P S +FR P AIDL+ R+L R++A EAL H +F + Sbjct: 275 EHKFPQIRPHP---FSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDELRTG 331 Query: 315 E 315 E Sbjct: 332 E 332 >3BHH-A nrPDB Length = 295 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 78/300 (26%), Positives = 128/300 (42%), Gaps = 44/300 (14%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 + Q +G GA+ V + A K ++ S ++ RE R+ + LK Sbjct: 2 MTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLK 61 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRG 137 H N++ L D SI + YLV L+ G +IV + S+ + Q+L Sbjct: 62 HSNIVRLHD------SISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEA 115 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCE---LRILDFGLARQADEEMT---GYVATRWYRAP 191 + + H G++HRDLKP N+ + C+ +++ DFGLA + + G+ T Y +P Sbjct: 116 VLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSP 175 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV-VGTPSPEVLAKI 250 E++ Y + VDIW+ G I+ LL G F D ++I PSPE Sbjct: 176 EVL-RKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPE----- 229 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + P A +L+ +ML ++ +R++A EAL H + Q Sbjct: 230 -----------------------WDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQ 266 >3GC0-A nrPDB Length = 329 Score = 267 bits (684), Expect = 4e-72, Method: Composition-based stats. Identities = 104/299 (34%), Positives = 150/299 (50%), Gaps = 18/299 (6%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 R + + +G G YG V A D + VA+K++ + RE+ LLK L+H Sbjct: 34 DRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHR 93 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV-KCQALSDEHVQFLVYQLLRGLKY 140 N+I L V I ++L+ DL + K +S ++ +YQL+ G+ + Sbjct: 94 NIIELKSV------IHHNHRLHLIFEYAENDLKKYMDKNPDVSMRVIKSFLYQLINGVNF 147 Query: 141 IHSAGIIHRDLKPSNVAV-----NEDCELRILDFGLARQAD---EEMTGYVATRWYRAPE 192 HS +HRDLKP N+ + +E L+I DFGLAR + T + T WYR PE Sbjct: 148 CHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPE 207 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 I+L HY+ +VDIWS+ CI AE+L LFPG IDQL +I EV+G P +++ Sbjct: 208 ILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTA 267 Query: 253 EHARTYIQSLPPMPQKDLSSIFRG-ANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + QS P K L + + +DLL ML +D +R+SA AL H YFS Sbjct: 268 --LPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFSH 324 >3H4J-B nrPDB Length = 336 Score = 267 bits (683), Expect = 6e-72, Method: Composition-based stats. Identities = 74/315 (23%), Positives = 137/315 (43%), Gaps = 45/315 (14%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR-RTYRELRLLKHLKHEN 82 +G G++G V A + +QKVA+K +SR R RE+ LK L+H + Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV-KCQALSDEHVQFLVYQLLRGLKYI 141 +I L DV T T ++ +V G +L + + + + ++++ + Q++ ++Y Sbjct: 71 IIKLYDVITTPT------DIVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYC 124 Query: 142 HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE--EMTGYVATRWYRAPEIMLNWMH 199 H I+HRDLKP N+ ++++ ++I DFGL+ + + + Y APE++ ++ Sbjct: 125 HRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLY 184 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI 259 VD+WS G ++ +L G+ F + K++ V Sbjct: 185 AGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPD--------------- 229 Query: 260 QSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS----QYHDPE 315 +P A L+ RM+V D QR++ E +F+ Y P Sbjct: 230 ----------------FLSPGAQSLIRRMIVADPMQRITIQEIRRDPWFNVNLPDYLRPM 273 Query: 316 DEPEAEPYDESVEAK 330 +E + D + +K Sbjct: 274 EEVQGSYADSRIVSK 288 >5ES1-A nrPDB Length = 328 Score = 267 bits (683), Expect = 6e-72, Method: Composition-based stats. Identities = 75/330 (22%), Positives = 141/330 (42%), Gaps = 50/330 (15%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 + LR +G G + V A ++VA+K + + + ++ +RE+R++K L H N Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPN 75 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTL--MGADLNNIVKCQALSDEHVQFLVYQLLRGLKY 140 ++ L +V IE +YLV G + +V + ++ + Q++ + Y Sbjct: 76 IVKLFEV------IETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHY 129 Query: 141 IHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWM 198 H I+HRDLK N+ ++ + ++I DFG + + ++ + + Y APE+ Sbjct: 130 CHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKK 189 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 + VDIWS+G I+ L+ G F G + + +R++ Sbjct: 190 YDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKY------------------ 231 Query: 259 IQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPED-E 317 +P D SI L R LVL+ +R + + + + + ++ E+ + Sbjct: 232 --RVPFYMSTDCESI-----------LRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELK 278 Query: 318 PEAEPYDESVEAKE--------RTLEEWKE 339 P EP ++ + K T EE KE Sbjct: 279 PYTEPEEDFGDTKRIEVMVGMGYTREEIKE 308 >4BGQ-A nrPDB Length = 304 Score = 266 bits (681), Expect = 8e-72, Method: Composition-based stats. Identities = 97/302 (32%), Positives = 151/302 (50%), Gaps = 16/302 (5%) Query: 16 TVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLL 75 + V + + L VG GAYG V + VA+KK ++ T REL++L Sbjct: 6 NIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKML 65 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC--QALSDEHVQFLVYQ 133 + LK EN++ L + F ++YLV + ++ +++ + E V+ +YQ Sbjct: 66 RTLKQENIVELKEAFRRRG------KLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQ 119 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE----EMTGYVATRWYR 189 L++ + + H I+HRD+KP N+ ++ + L++ DFG AR E VATRWYR Sbjct: 120 LIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYR 179 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249 +PE++L Y ++VD+WSVGCI+ EL G+ LFPG IDQL I +V+G P P K Sbjct: 180 SPELLLG-APYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLG-PLPSEQMK 237 Query: 250 ISSEHARTYIQSLPP--MPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 + + R + P PQ N + +DL+ +L LD R + L H Sbjct: 238 LFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPT 297 Query: 308 FS 309 F Sbjct: 298 FQ 299 >3KK8-A nrPDB Length = 284 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 75/299 (25%), Positives = 125/299 (41%), Gaps = 43/299 (14%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 +G GA+ V + A K ++ S ++ RE R+ + L+ Sbjct: 4 FSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQ 63 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRG 137 H N++ L D SI++ S YLV L+ G +IV + S+ + Q+L Sbjct: 64 HPNIVRLHD------SIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILES 117 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCE---LRILDFGLARQADEE--MTGYVATRWYRAPE 192 + Y HS GI+HR+LKP N+ + + +++ DFGLA + ++ G+ T Y +PE Sbjct: 118 IAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPE 177 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV-VGTPSPEVLAKIS 251 ++ Y++ VDIW+ G I+ LL G F D +I PSPE Sbjct: 178 VLKKD-PYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPE------ 230 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + P A L+ ML ++ +R++A +AL + Sbjct: 231 ----------------------WDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICN 267 >5KZ7-A nrPDB Length = 346 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 70/330 (21%), Positives = 139/330 (42%), Gaps = 42/330 (12%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 + L+ +G G + V A ++VAVK + + + ++ +RE+R++K L H N Sbjct: 34 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN 93 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKY 140 ++ L +V IE +YLV G + +V + ++ + Q++ ++Y Sbjct: 94 IVKLFEV------IETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 147 Query: 141 IHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWM 198 H I+HRDLK N+ ++ D ++I DFG + + ++ + + Y APE+ Sbjct: 148 CHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKK 207 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 + VD+WS+G I+ L+ G F G + + +R++ Sbjct: 208 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY------------------ 249 Query: 259 IQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYH-DPEDE 317 I + +LL + L+L+ +R + + + + + H D E + Sbjct: 250 -------------RIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELK 296 Query: 318 PEAEPYDESVEAKERTLEEWKELTYQEVLS 347 P EP + + + L T +E+ Sbjct: 297 PYVEPLPDYKDPRRTELMVSMGYTREEIQD 326 >4RED-A nrPDB Length = 351 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 89/334 (26%), Positives = 139/334 (41%), Gaps = 48/334 (14%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKHE 81 +G G +G V VAVK L+R +SL + RE++ LK +H Sbjct: 15 HYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 74 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV-KCQALSDEHVQFLVYQLLRGLK 139 ++I L V + S++++V + G +L + + K L ++ + L Q+L G+ Sbjct: 75 HIIKLYQVISTP------SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 128 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--DEEMTGYVATRWYRAPEIMLNW 197 Y H ++HRDLKP NV ++ +I DFGL+ E + + Y APE++ Sbjct: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257 ++ VDIWS G I+ LL G F K+I + + Sbjct: 189 LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTP-------------- 234 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ----YHD 313 + NP I LL ML +D +R S + H +F Q Y Sbjct: 235 -----------------QYLNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYLF 277 Query: 314 PEDEPEAEPYDESVEAKERTLEEWKELTYQEVLS 347 PED P EA + E++ E + +EVLS Sbjct: 278 PED-PSYSTTMIDDEALKEVCEKF-ECSEEEVLS 309 >4CFH-A nrPDB Length = 493 Score = 265 bits (677), Expect = 2e-71, Method: Composition-based stats. Identities = 89/334 (26%), Positives = 140/334 (41%), Gaps = 48/334 (14%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKHE 81 +G G +G V KVAVK L+R +SL + RE++ LK +H Sbjct: 34 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 93 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV-KCQALSDEHVQFLVYQLLRGLK 139 ++I L V + S++++V + G +L + + K L ++ + L Q+L G+ Sbjct: 94 HIIKLYQVISTP------SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 147 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--DEEMTGYVATRWYRAPEIMLNW 197 Y H ++HRDLKP NV ++ +I DFGL+ E + + Y APE++ Sbjct: 148 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 207 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257 ++ VDIWS G I+ LL G F K+I + + Sbjct: 208 LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTP-------------- 253 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ----YHD 313 + NP I LL ML +D +R + + H +F Q Y Sbjct: 254 -----------------QYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLF 296 Query: 314 PEDEPEAEPYDESVEAKERTLEEWKELTYQEVLS 347 PED P EA + E++ E + +EVLS Sbjct: 297 PED-PSYSSTMIDDEALKEVCEKF-ECSEEEVLS 328 >5ZTN-A nrPDB Length = 429 Score = 263 bits (673), Expect = 7e-71, Method: Composition-based stats. Identities = 93/346 (26%), Positives = 166/346 (47%), Gaps = 41/346 (11%) Query: 2 SGPRAGFYRQELNKTVW----EVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR 57 GP G Y + V V R + L+ +G G++G V AYD ++ Q VA+K + Sbjct: 73 GGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRN 132 Query: 58 PFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV 117 + R+ E+R+L+HL+ ++ ++V + + + + L+ +L ++ Sbjct: 133 EKR---FHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELI 189 Query: 118 KC---QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE--LRILDFGLA 172 K Q S V+ + +L+ L +H IIH DLKP N+ + + ++++DFG + Sbjct: 190 KKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSS 249 Query: 173 RQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQL 232 + + Y+ +R+YRAPE++L Y +D+WS+GCI+AELL G L PG D DQL Sbjct: 250 CYEHQRVYTYIQSRFYRAPEVILGAR-YGMPIDMWSLGCILAELLTGYPLLPGEDEGDQL 308 Query: 233 KRIMEVVGTPSPEVLAK-------ISSEHARTYI--------------------QSLPPM 265 ++E++G PS ++L +SS+ Y + P Sbjct: 309 ACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPP 368 Query: 266 PQKDLSSIFRGA-NPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 ++ + +G +PL +D L + L D R++ +AL H + + Sbjct: 369 ESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRR 414 >2QNJ-A nrPDB Length = 328 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 65/305 (21%), Positives = 132/305 (43%), Gaps = 42/305 (13%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 + L+ +G G + V A ++VA+K + + + ++ +RE+R++K L H N Sbjct: 13 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPN 72 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKY 140 ++ L +V IE +YL+ G + +V + ++ + Q++ ++Y Sbjct: 73 IVKLFEV------IETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQY 126 Query: 141 IHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWM 198 H I+HRDLK N+ ++ D ++I DFG + + ++ + + Y APE+ Sbjct: 127 CHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKK 186 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 + VD+WS+G I+ L+ G F G + + +R++ Sbjct: 187 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY------------------ 228 Query: 259 IQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPED-E 317 I + +LL R LVL+ +R + + + + + H+ ++ + Sbjct: 229 -------------RIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELK 275 Query: 318 PEAEP 322 P EP Sbjct: 276 PFVEP 280 >5IG1-A nrPDB Length = 344 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 72/290 (24%), Positives = 126/290 (43%), Gaps = 43/290 (14%) Query: 29 PVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 +G GA+ +V + R + AVK ++ + RE+ + L+HE+++ + Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRR 83 Query: 89 VFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 F D S YLV + G + IV + +++ ++Q+L L++ HS I Sbjct: 84 AFR------DESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNI 137 Query: 147 IHRDLKPSNVAV---NEDCELRILDFGLARQADEEMT--GYVATRWYRAPEIMLNWMHYN 201 IHRDLKP N+ + + + ++I DFGLA ++ T G+ T Y +PE++ + Y+ Sbjct: 138 IHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVI-RRVPYD 196 Query: 202 QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV-VGTPSPEVLAKISSEHARTYIQ 260 VD+W+ G I+ LL G F D+ +I PSPE Sbjct: 197 TAVDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPE--------------- 241 Query: 261 SLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + A +L+ ML + +R + E L H + ++ Sbjct: 242 -------------WDSVTTAAKELIKAMLEPNPKRRPTVQELLQHPWIAR 278 >2YCR-A nrPDB Length = 323 Score = 259 bits (662), Expect = 1e-69, Method: Composition-based stats. Identities = 96/348 (27%), Positives = 150/348 (43%), Gaps = 59/348 (16%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR------TYRELRLL 75 + +GSGA G V A++ + +KVA+K +S+ ++ AR E+ +L Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQ 133 K L H +I + + F D + Y+V LM G + +V + L + + YQ Sbjct: 70 KKLNHPCIIKIKNFF-------DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQ 122 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVN---EDCELRILDFGLARQADEE--MTGYVATRWY 188 +L ++Y+H GIIHRDLKP NV ++ EDC ++I DFG ++ E M T Y Sbjct: 123 MLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTY 182 Query: 189 RAPEIML--NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLK-RIMEVVGTPSPE 245 APE+++ YN+ VD WS+G I+ L G F LK +I PE Sbjct: 183 LAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPE 242 Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAH 305 V A++ + A+DL+ ++LV+D R + EAL H Sbjct: 243 VWAEV---------------------------SEKALDLVKKLLVVDPKARFTTEEALRH 275 Query: 306 AY---------FSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQE 344 + F E+E A+P + + R E E Sbjct: 276 PWLQDEDMKRKFQDLLSEENESTAKPQVLAQPSTSRKRPREGEAEGAE 323 >3E3P-A nrPDB Length = 360 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 101/310 (32%), Positives = 155/310 (50%), Gaps = 23/310 (7%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL--- 78 R Q R G G +G+V + VA+KK+ + R REL++++ L Sbjct: 23 DRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKV------IQDPRFRNRELQIMQDLAVL 76 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYL--VTTLMGADL-----NNIVKCQALSDEHVQFLV 131 H N++ L F D ++YL V + L N + A ++ + Sbjct: 77 HHPNIVQLQSYFYTLGE-RDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFL 135 Query: 132 YQLLRGLKYIH--SAGIIHRDLKPSNVAVNE-DCELRILDFGLARQAD--EEMTGYVATR 186 +QL+R + +H S + HRD+KP NV VNE D L++ DFG A++ E Y+ +R Sbjct: 136 FQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSR 195 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEV 246 +YRAPE++ HY VDIWSVGCI AE++ G+ +F G + QL I+ V+G PS EV Sbjct: 196 YYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREV 255 Query: 247 LAKISSEHARTYIQSLPPMPQKDLSSIFRGANP-LAIDLLGRMLVLDSDQRVSAAEALAH 305 L K++ H + + +P ++ S + A DLL +L ++R+ EAL H Sbjct: 256 LRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEALCH 315 Query: 306 AYFSQYHDPE 315 YF + HDP Sbjct: 316 PYFDELHDPA 325 >3EB0-A nrPDB Length = 383 Score = 256 bits (655), Expect = 8e-69, Method: Composition-based stats. Identities = 100/332 (30%), Positives = 165/332 (49%), Gaps = 50/332 (15%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 ++ + +G+G++G VC +D ++ A+KK+ L R REL ++K L H Sbjct: 7 KKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKV------LQDPRYKNRELDIMKVLDHV 60 Query: 82 NVIGLLDVFTPATSIE--------------------------------DFSEVYLVTTLM 109 N+I L+D F E + ++ + Sbjct: 61 NIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYV 120 Query: 110 GADLNNIVKC-----QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCE 163 L+ ++K +++ + +YQL R + +IHS GI HRD+KP N+ VN +D Sbjct: 121 PDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNT 180 Query: 164 LRILDFGLARQA--DEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKA 221 L++ DFG A++ E Y+ +R+YRAPE+ML Y ++D+WS+GC+ EL+ GK Sbjct: 181 LKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKP 240 Query: 222 LFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANP-L 280 LF G IDQL RI++++GTP+ E + +++ + P + KD I P L Sbjct: 241 LFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEV---RFPTLKAKDWRKILPEGTPSL 297 Query: 281 AIDLLGRMLVLDSDQRVSAAEALAHAYFSQYH 312 AIDLL ++L + D R++ EA+AH +F Sbjct: 298 AIDLLEQILRYEPDLRINPYEAMAHPFFDHLR 329 >5WAX-A nrPDB Length = 310 Score = 256 bits (655), Expect = 9e-69, Method: Composition-based stats. Identities = 75/336 (22%), Positives = 132/336 (39%), Gaps = 43/336 (12%) Query: 12 ELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRE 71 ++ + R + +R +GSG +G + Q VAVK + R + RE Sbjct: 1 SMDMPIMHDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKID---ENVQRE 57 Query: 72 LRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQF 129 + + L+H N+I +V T + +V G I S++ +F Sbjct: 58 IINHRSLRHPNIIRFKEVILTPT------HLAIVMEYASGGELFERICNAGRFSEDEARF 111 Query: 130 LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDC--ELRILDFGLARQ--ADEEMTGYVAT 185 QL+ G+ Y HS + HRDLK N ++ L+I DFG ++ + V T Sbjct: 112 FFQQLISGVSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGT 171 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKR-IMEVVGTPSP 244 Y APE++L + + D+WS G + +L G F D ++ I ++G Sbjct: 172 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILG---- 227 Query: 245 EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 S+P + +P DL+ R+ V + R++ E Sbjct: 228 -------------VQYSIPD---------YVHISPECQDLISRIFVANPATRITIPEIRN 265 Query: 305 HAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKEL 340 H +F + + P D + + E E+ ++ E+ Sbjct: 266 HPWFLK-NLPADLMDDSTMSKQYEEPEQPMQSMDEI 300 >5YKS-A nrPDB Length = 377 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 75/329 (22%), Positives = 139/329 (42%), Gaps = 47/329 (14%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 + +G G + V A +KVAVK + + + ++E+R +K ++H N+ Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI 96 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV--KCQALSDEHVQFLVYQLLRGLKY 140 + L +V I+ +++YL+ L G D+ + + + L+++ + Q++ + Y Sbjct: 97 VRLYEV------IDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 150 Query: 141 IHSAGIIHRDLKPSNV-AVNEDCELRILDFGLAR--QADEEMTGYVATRWYRAPEIMLNW 197 H ++HRDLKP NV + +++ DFG + Q +++T + Y APEI+L Sbjct: 151 CHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGD 210 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257 + VDIWS+G I+ L+ G+ F ++ + L IM+ T Sbjct: 211 EYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYT---------------- 254 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDE 317 + + DL+ RML D +R S E H + D Sbjct: 255 ---------------VPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQ----GVDP 295 Query: 318 PEAEPYDESVEAKERTLEEWKELTYQEVL 346 A Y+ + + + EE Q ++ Sbjct: 296 SPATKYNIPLVSYKNLSEEEHNSIIQRMV 324 >4CZT-A nrPDB Length = 464 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 78/333 (23%), Positives = 136/333 (40%), Gaps = 53/333 (15%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKHE 81 + + R +G G + V A + VA+K + + + RE+ +K +KH Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 71 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLK 139 NVI + +V T ++Y V + G + I L ++ + QL+ + Sbjct: 72 NVIRMFEVMASKT------KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 125 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR-----QADEEMTGYVATRWYRAPEIM 194 Y HS G+ HRDLKP N+ ++ + L++ DFGL+ + D + T Y APE++ Sbjct: 126 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 185 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH 254 N + D+WS G I+ L+ G F S+ K+I + T P Sbjct: 186 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP---------- 235 Query: 255 ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ-YHD 313 + A L+ R+L + R++ AE + + +F + Y Sbjct: 236 ---------------------WFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 274 Query: 314 PEDEPEAEP-------YDESVEAKERTLEEWKE 339 P+ E +D+S E+K +E +E Sbjct: 275 PKFENADVSLDDVDAIFDDSGESKNLVVERREE 307 >4FG9-A nrPDB Length = 320 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 132/298 (44%), Gaps = 42/298 (14%) Query: 19 EVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL 78 ++ +G+GA+ V A D R ++ VA+K +++ E+ +L + Sbjct: 15 DIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKI 73 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLR 136 KH N++ L D++ +YL+ L+ G + IV+ ++ L++Q+L Sbjct: 74 KHPNIVALDDIYESGG------HLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLD 127 Query: 137 GLKYIHSAGIIHRDLKPSNVA---VNEDCELRILDFGLARQAD--EEMTGYVATRWYRAP 191 +KY+H GI+HRDLKP N+ ++ED ++ I DFGL++ D ++ T Y AP Sbjct: 128 AVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAP 187 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 E++ Y++ VD WS+G I LL G F + ++I++ Sbjct: 188 EVLA-QKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFD-------- 238 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 S + + A D + ++ D ++R + +AL H + + Sbjct: 239 -------------------SPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIA 277 >3IS5-A nrPDB Length = 285 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 91/320 (28%), Positives = 143/320 (44%), Gaps = 54/320 (16%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 61 S R Y Q ++ R +GSGA+G V + + +K +++ +S Sbjct: 8 SSGRENLYFQGTIDDLFIFK------RKLGSGAFGDVHLVEERSSGLERVIKTINKD-RS 60 Query: 62 LIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIV-- 117 + + E+ +LK L H N+I + +VF ED+ +Y+V G L IV Sbjct: 61 QVPMEQIEAEIEVLKSLDHPNIIKIFEVF------EDYHNMYIVMETCEGGELLERIVSA 114 Query: 118 --KCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNE---DCELRILDFGLA 172 + +ALS+ +V L+ Q++ L Y HS ++H+DLKP N+ + ++I+DFGLA Sbjct: 115 QARGKALSEGYVAELMKQMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLA 174 Query: 173 R--QADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID 230 ++DE T T Y APE+ + DIWS G +M LL G F G+ Sbjct: 175 ELFKSDEHSTNAAGTALYMAPEVFKRDV--TFKCDIWSAGVVMYFLLTGCLPFTGTSL-- 230 Query: 231 QLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLV 290 EV K + + ++ P P A+DLL +ML Sbjct: 231 -------------EEVQQKATYKEPNYAVECRP-------------LTPQAVDLLKQMLT 264 Query: 291 LDSDQRVSAAEALAHAYFSQ 310 D ++R SAA+ L H +F Q Sbjct: 265 KDPERRPSAAQVLHHEWFKQ 284 >2JC6-A nrPDB Length = 334 Score = 254 bits (650), Expect = 4e-68, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 131/298 (43%), Gaps = 42/298 (14%) Query: 19 EVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL 78 ++ + + +G+GA+ V A + + AVK + + + E+ +L+ + Sbjct: 19 DIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESS-IENEIAVLRKI 77 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLR 136 KHEN++ L D++ + +YLV L+ G + IV+ +++ L+ Q+L Sbjct: 78 KHENIVALEDIYESP------NHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLD 131 Query: 137 GLKYIHSAGIIHRDLKPSNVAV---NEDCELRILDFGLARQAD--EEMTGYVATRWYRAP 191 + Y+H GI+HRDLKP N+ +E+ ++ I DFGL++ + M+ T Y AP Sbjct: 132 AVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAP 191 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 E++ Y++ VD WS+G I LL G F + ++I++ Sbjct: 192 EVLA-QKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFD-------- 242 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 S + + A D + ++ D ++R + +A H + + Sbjct: 243 -------------------SPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIA 281 >4D2V-A nrPDB Length = 356 Score = 254 bits (648), Expect = 7e-68, Method: Composition-based stats. Identities = 72/323 (22%), Positives = 133/323 (41%), Gaps = 45/323 (13%) Query: 10 RQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTY 69 R K E+ + + +G+G + V A + VA+K + + R Sbjct: 17 RGSHMKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIK 75 Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHV 127 E+ LK+L+H+++ L V +E +++++V G + I+ LS+E Sbjct: 76 TEIEALKNLRHQHICQLYHV------LETANKIFMVLEYCPGGELFDYIISQDRLSEEET 129 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA----DEEMTGYV 183 + + Q++ + Y+HS G HRDLKP N+ +E +L+++DFGL + D + Sbjct: 130 RVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACC 189 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPS 243 Y APE++ + D+WS+G ++ L+ G F + +IM Sbjct: 190 GALAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKY--- 246 Query: 244 PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEAL 303 + + +P +I LL +ML +D +R+S L Sbjct: 247 ----------------------------DVPKWLSPSSILLLQQMLQVDPKKRISMKNLL 278 Query: 304 AHAYFSQ-YHDPEDEPEAEPYDE 325 H + Q Y+ P + P+ Sbjct: 279 NHPWIMQDYNYPVEWQSKNPFIH 301 >4CQG-A nrPDB Length = 331 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 74/321 (23%), Positives = 134/321 (41%), Gaps = 45/321 (14%) Query: 15 KTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRL 74 K E+ + + +G+G + V A + VA+K + + R E+ Sbjct: 2 KDYDELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALG-SDLPRVKTEIDA 60 Query: 75 LKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVY 132 LK L+H+++ L V +E +++++V G + I+ LS+E + + Sbjct: 61 LKSLRHQHICQLYHV------LETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFR 114 Query: 133 QLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA----DEEMTGYVATRWY 188 Q+L + Y+HS G HRDLKP N+ +E+ +L+++DFGL + D + + Y Sbjct: 115 QILSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAY 174 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLA 248 APE++ + D+WS+G ++ L+ G F + + K+IM Sbjct: 175 AAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKY-------- 226 Query: 249 KISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 + + +P +I LL +ML +D +R+S L H + Sbjct: 227 -----------------------EVPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWV 263 Query: 309 SQ-YHDPEDEPEAEPYDESVE 328 Q Y P + P E Sbjct: 264 MQDYSCPVEWQSKTPLTHLDE 284 >3F3Z-A nrPDB Length = 277 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 75/304 (24%), Positives = 127/304 (41%), Gaps = 44/304 (14%) Query: 14 NKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELR 73 T ++ Q +G G++G V A R + A KK+ + F + R +E+ Sbjct: 1 GSTKGDINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYF--VEDVDRFKQEIE 58 Query: 74 LLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLV 131 ++K L H N+I L + F ED +++YLV L G +V + + ++ Sbjct: 59 IMKSLDHPNIIRLYETF------EDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIM 112 Query: 132 YQLLRGLKYIHSAGIIHRDLKPSNVAV---NEDCELRILDFGLAR--QADEEMTGYVATR 186 +L + Y H + HRDLKP N + D L+++DFGLA + + M V T Sbjct: 113 KDVLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTP 172 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEV 246 +Y +P+++ Y D WS G +M LL G F + + +I E T + Sbjct: 173 YYVSPQVLEGL--YGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKD 230 Query: 247 LAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHA 306 + +P A L+ R+L QR+++ +AL H Sbjct: 231 WLNV---------------------------SPQAESLIRRLLTKSPKQRITSLQALEHE 263 Query: 307 YFSQ 310 +F + Sbjct: 264 WFEK 267 >3COM-A nrPDB Length = 314 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 65/311 (20%), Positives = 131/311 (42%), Gaps = 45/311 (14%) Query: 4 PRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLI 63 PR + + + + + L +G G+YGSV A Q VA+K++ Sbjct: 11 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE----S 66 Query: 64 HARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNI--VKCQ 120 + +E+ +++ +V+ + T ++++V G +++I ++ + Sbjct: 67 DLQEIIKEISIMQQCDSPHVVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIRLRNK 120 Query: 121 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM- 179 L+++ + ++ L+GL+Y+H IHRD+K N+ +N + ++ DFG+A Q + M Sbjct: 121 TLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMA 180 Query: 180 --TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME 237 + T ++ APE++ + YN DIWS+G E+ +GK + I ++ I Sbjct: 181 KRNTVIGTPFWMAPEVI-QEIGYNCVADIWSLGITAIEMAEGKPPYA---DIHPMRAIFM 236 Query: 238 VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV 297 + P P + D + + LV +QR Sbjct: 237 IPTNPPPTFRK-------------------------PELWSDNFTDFVKQCLVKSPEQRA 271 Query: 298 SAAEALAHAYF 308 +A + L H + Sbjct: 272 TATQLLQHPFV 282 >3I6U-A nrPDB Length = 419 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 87/305 (28%), Positives = 138/305 (45%), Gaps = 50/305 (16%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR------TYRELRLL 75 + +GSGA G V A++ + +KVA++ +S+ ++ AR E+ +L Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQ 133 K L H +I + + F D + Y+V LM G + +V + L + + YQ Sbjct: 195 KKLNHPCIIKIKNFF-------DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQ 247 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVN---EDCELRILDFGLARQADEE--MTGYVATRWY 188 +L ++Y+H GIIHRDLKP NV ++ EDC ++I DFG ++ E M T Y Sbjct: 248 MLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTY 307 Query: 189 RAPEIML--NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLK-RIMEVVGTPSPE 245 APE+++ YN+ VD WS+G I+ L G F LK +I PE Sbjct: 308 LAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPE 367 Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAH 305 V A++ + A+DL+ ++LV+D R + EAL H Sbjct: 368 VWAEV---------------------------SEKALDLVKKLLVVDPKARFTTEEALRH 400 Query: 306 AYFSQ 310 + Sbjct: 401 PWLQD 405 >5JZN-A nrPDB Length = 280 Score = 251 bits (641), Expect = 3e-67, Method: Composition-based stats. Identities = 83/313 (26%), Positives = 142/313 (45%), Gaps = 49/313 (15%) Query: 11 QELNKTVWEVP----QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR 66 +E+++ +++P +R + R +G G + V + ++ A+K + + + Sbjct: 4 EEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKS-KCRGKEH 62 Query: 67 RTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNN-IVKCQALSD 124 E+ +L+ +KH N++ L++ ++ +E+YLV L+ G DL + I ++ Sbjct: 63 MIQNEVSILRRVKHPNIVLLIE------EMDVPTELYLVMELVKGGDLFDAITSTNKYTE 116 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAV----NEDCELRILDFGLARQADEEMT 180 ++Y L +KY+HS I+HRD+KP N+ V + L++ DFGLA D + Sbjct: 117 RDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLY 176 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGS-DYIDQL--KRIME 237 T Y APEI+ Y VDIW+ G I LL G F GS D + L + +M Sbjct: 177 TVCGTPTYVAPEIIA-ETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMG 235 Query: 238 VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV 297 V PSP + + A +L+ ML++D DQR Sbjct: 236 QVDFPSP----------------------------YWDNVSDSAKELITMMLLVDVDQRF 267 Query: 298 SAAEALAHAYFSQ 310 SA + L H + + Sbjct: 268 SAVQVLEHPWVND 280 >3MV5-A nrPDB Length = 342 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 75/358 (20%), Positives = 146/358 (40%), Gaps = 55/358 (15%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQSLIHARRTYRELRLLKHLKH 80 + L+ +G G +G V + + A+K L + + T E R+L++ +H Sbjct: 10 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 69 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGL 138 + L F + V G ++ + + S++ +F +++ L Sbjct: 70 PFLTALKYSFQTH------DRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 123 Query: 139 KYIHS-AGIIHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYRAPEIM 194 Y+HS +++RDLK N+ +++D ++I DFGL ++ M + T Y APE++ Sbjct: 124 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 183 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRI-MEVVGTPSPEVLAKISSE 253 + Y + VD W +G +M E++ G+ F D+ + I ME + P Sbjct: 184 EDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----------- 231 Query: 254 HARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEALAHAYF 308 R P A LL +L D QR+ A E + H +F Sbjct: 232 ---------------------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 270 Query: 309 S--QYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSLEIEQ 364 + + ++ + P+ V ++ T +E T ++++ PP+ ++ E+ Sbjct: 271 AGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT-AQMITITPPDQDDSMECVDSER 327 >2YZA-A nrPDB Length = 276 Score = 250 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 78/302 (25%), Positives = 120/302 (39%), Gaps = 42/302 (13%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKHE 81 +G G +G V KVAVK L+R +SL + RE++ LK +H Sbjct: 12 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 71 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV-KCQALSDEHVQFLVYQLLRGLK 139 ++I L V + T + ++V + G +L + + K + + + L Q+L + Sbjct: 72 HIIKLYQVISTPT------DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 125 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--DEEMTGYVATRWYRAPEIMLNW 197 Y H ++HRDLKP NV ++ +I DFGL+ E + + Y APE++ Sbjct: 126 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGR 185 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257 ++ VDIWS G I+ LL G F K+I V PE L Sbjct: 186 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY-IPEYL---------- 234 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDE 317 N LL ML +D +R + + H +F Q Sbjct: 235 --------------------NRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLF 274 Query: 318 PE 319 PE Sbjct: 275 PE 276 >5XZW-A nrPDB Length = 471 Score = 250 bits (639), Expect = 6e-67, Method: Composition-based stats. Identities = 82/299 (27%), Positives = 130/299 (43%), Gaps = 52/299 (17%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 VG GA+ +V A + + AVK +S+ + + + REL +L+ L H ++ L Sbjct: 202 EVVGQGAFATVKKAIERTTGKTFAVKIISKR-KVIGNMDGVTRELEVLQKLNHPRIVRLK 260 Query: 88 DVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA-LSDEHVQFLVYQLLRGLKYIHSAG 145 + ED Y+V + G DL + V + ++ + + Q+L +KYIHS G Sbjct: 261 GFY------EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMG 314 Query: 146 IIHRDLKPSNVAVNEDCEL--RILDFGLAR--QADEEMTGYVATRWYRAPEIMLN----- 196 I HRDLKP N+ + +D + +I DFGLA+ M + T Y APE++ Sbjct: 315 ISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSV 374 Query: 197 -------WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249 Y+ VD+WS+GC++ +L G F GS K+I Sbjct: 375 SPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRG----------- 423 Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 S P KD + A D + +L +D + R +AA+AL H + Sbjct: 424 -----------SYHEGPLKDFR-----ISEEARDFIDSLLQVDPNNRSTAAKALNHPWI 466 >4JG6-A nrPDB Length = 355 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 80/312 (25%), Positives = 139/312 (44%), Gaps = 49/312 (15%) Query: 11 QELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR 70 Q+L++ + + +G G+Y + AVK + + + Sbjct: 24 QQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE------ 77 Query: 71 ELRLL-KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHV 127 E+ +L ++ +H N+I L DV+ +D VY+VT LM G L+ I++ + S+ Sbjct: 78 EIEILLRYGQHPNIITLKDVY------DDGKYVYVVTELMKGGELLDKILRQKFFSEREA 131 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVA-VNEDCE---LRILDFGLARQADEEMTGYV 183 +++ + + ++Y+H+ G++HRDLKPSN+ V+E +RI DFG A+Q E G + Sbjct: 132 SAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAE-NGLL 190 Query: 184 ATRWY----RAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVV 239 T Y APE++ Y+ DIWS+G ++ +L G F Sbjct: 191 MTPCYTANFVAPEVLER-QGYDAACDIWSLGVLLYTMLTGYTPF------------ANGP 237 Query: 240 GTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSA 299 E+LA+I S + + A DL+ +ML +D QR++A Sbjct: 238 DDTPEEILARIGSGKFSLS------------GGYWNSVSDTAKDLVSKMLHVDPHQRLTA 285 Query: 300 AEALAHAYFSQY 311 A L H + + Sbjct: 286 ALVLRHPWIVHW 297 >4NIF-A nrPDB Length = 333 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 81/298 (27%), Positives = 135/298 (45%), Gaps = 49/298 (16%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLL-KHLKHEN 82 +G G+Y + AVK + + + E+ +L ++ +H N Sbjct: 10 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE------EIEILLRYGQHPN 63 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKY 140 +I L DV+ +D VYLVT LM G L+ I++ + S+ F+++ + + ++Y Sbjct: 64 IITLKDVY------DDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEY 117 Query: 141 IHSAGIIHRDLKPSNVA-VNEDCE---LRILDFGLARQADEEMTGYVATRWY----RAPE 192 +HS G++HRDLKPSN+ V+E LRI DFG A+Q E G + T Y APE Sbjct: 118 LHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAE-NGLLMTPCYTANFVAPE 176 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 ++ Y++ DIWS+G ++ +L G F E+L +I S Sbjct: 177 VL-KRQGYDEGCDIWSLGILLYTMLAGYTPF------------ANGPSDTPEEILTRIGS 223 Query: 253 EHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + + + A DL+ +ML +D QR++A + L H + +Q Sbjct: 224 GKFTLSGGN------------WNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQ 269 >3D2K-A nrPDB Length = 272 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 77/300 (25%), Positives = 127/300 (42%), Gaps = 43/300 (14%) Query: 14 NKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQSLIHARRTYREL 72 +K W + + RP+G G +G+V A + + + +A+K L + + + RE+ Sbjct: 5 SKRQWTL-EDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREV 63 Query: 73 RLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTL--MGADLNNIVKCQALSDEHVQFL 130 + HL+H N++ L F D + VYL+ +G + K ++ Sbjct: 64 EIQSHLRHPNILRLYGYF------HDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATY 117 Query: 131 VYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRWYR 189 + +L L Y HS +IHRD+KP N+ + + EL+I DFG + A T T Y Sbjct: 118 ITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYL 177 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249 PE++ MH ++ VD+WS+G + E L G F Y + +RI V T Sbjct: 178 PPEMIEGRMH-DEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPD----- 231 Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 A DL+ R+L ++ QR++ AE L H + Sbjct: 232 --------------------------FVTEGARDLISRLLKHNASQRLTLAEVLEHPWIK 265 >3ZUT-A nrPDB Length = 362 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 76/367 (20%), Positives = 141/367 (38%), Gaps = 52/367 (14%) Query: 11 QELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR 70 ++ + R + ++ +GSG +G D + + VAVK + R + R Sbjct: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID---ENVKR 64 Query: 71 ELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQ 128 E+ + L+H N++ +V T + +V G I S++ + Sbjct: 65 EIINHRSLRHPNIVRFKEVILTPT------HLAIVMEYASGGELFERICNAGRFSEDEAR 118 Query: 129 FLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDC--ELRILDFGLARQ--ADEEMTGYVA 184 F QL+ G+ Y H+ + HRDLK N ++ L+I FG ++ + V Sbjct: 119 FFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVG 178 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSP 244 T Y APE++L + + D+WS G + +L G F + Sbjct: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEE---------------- 222 Query: 245 EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 K + + +P + +P L+ R+ V D +R+S E Sbjct: 223 ---PKNFRKTIHRILNVQYAIPD------YVHISPECRHLISRIFVADPAKRISIPEIRN 273 Query: 305 HAYFSQYHDPE---DEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPP---- 357 H +F + + D +DES + + ++EE ++ + + PP + Sbjct: 274 HEWFLKNLPADLMNDNTMTTQFDESDQPGQ-SIEEIMQIIAEATV---PPAGTQNLNHYL 329 Query: 358 -GSLEIE 363 GSL+I+ Sbjct: 330 TGSLDID 336 >2J90-A nrPDB Length = 304 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 76/318 (23%), Positives = 136/318 (42%), Gaps = 52/318 (16%) Query: 4 PRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLI 63 Y Q + V + +GSG + V ++ A K + + S Sbjct: 14 GTENLYFQSM------VEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSS 67 Query: 64 HA----RRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV- 117 RE+ +L+ ++H N+I L D+F E+ ++V L+ L+ G +L + + Sbjct: 68 RRGVSREEIEREVNILREIRHPNIITLHDIF------ENKTDVVLILELVSGGELFDFLA 121 Query: 118 KCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNE----DCELRILDFGLAR 173 + ++L+++ + Q+L G+ Y+HS I H DLKP N+ + + + ++++DFG+A Sbjct: 122 EKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAH 181 Query: 174 QA--DEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQ 231 + E T + APEI+ N+ D+WS+G I LL G + F G + Sbjct: 182 KIEAGNEFKNIFGTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGETKQET 240 Query: 232 LKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVL 291 L I V E F + LA D + R+LV Sbjct: 241 LTNISAVNYDFDEE---------------------------YFSNTSELAKDFIRRLLVK 273 Query: 292 DSDQRVSAAEALAHAYFS 309 D +R++ A++L H++ Sbjct: 274 DPKRRMTIAQSLEHSWIK 291 >3UC3-A nrPDB Length = 361 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 76/337 (22%), Positives = 130/337 (38%), Gaps = 48/337 (14%) Query: 5 RAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH 64 RA L+ + R ++ +GSG +G D ++ VAVK + R Sbjct: 3 RAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGA---AI 59 Query: 65 ARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNN-IVKCQAL 122 RE+ + L+H N++ +V T + ++ G +L I Sbjct: 60 DENVQREIINHRSLRHPNIVRFKEVILTPT------HLAIIMEYASGGELYERICNAGRF 113 Query: 123 SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDC--ELRILDFGLARQ--ADEE 178 S++ +F QLL G+ Y HS I HRDLK N ++ L+I DFG ++ + Sbjct: 114 SEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ 173 Query: 179 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG----SDYIDQLKR 234 V T Y APE++L + + D+WS G + +L G F DY ++R Sbjct: 174 PKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR 233 Query: 235 IMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSD 294 I+ V + ++ +P L+ R+ V D Sbjct: 234 ILSVKYSIPDDIR-----------------------------ISPECCHLISRIFVADPA 264 Query: 295 QRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKE 331 R+S E H++F + + E+ + E ++ Sbjct: 265 TRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQ 301 >2HAK-A nrPDB Length = 328 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 63/314 (20%), Positives = 127/314 (40%), Gaps = 41/314 (13%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 + + +G G + V A ++VAVK + + + ++ +RE+R++K L H N Sbjct: 16 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 75 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKY 140 ++ L +V IE +YLV G + +V + ++ + Q++ ++Y Sbjct: 76 IVKLFEV------IETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 129 Query: 141 IHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWM 198 H I+HRDLK N+ ++ D ++I DFG + + ++ + + Y APE+ Sbjct: 130 CHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKK 189 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 + VD+WS+G I+ L+ G F G + + +R++ Sbjct: 190 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY------------------ 231 Query: 259 IQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEP 318 +P D ++ + L +R S + + + + H+ E+ Sbjct: 232 --RIPFYMSTDCENLLKKLLVLN-----------PIKRGSLEQIMKDRWMNVGHEEEELK 278 Query: 319 EAEPYDESVEAKER 332 D +R Sbjct: 279 PYTEPDPDFNDTKR 292 >6FD3-A nrPDB Length = 300 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 70/298 (23%), Positives = 134/298 (44%), Gaps = 41/298 (13%) Query: 16 TVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLL 75 +V + ++ +G GA G+V +A D Q+VA+K+++ Q E+ ++ Sbjct: 16 SVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIINEILVM 73 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQL 134 + K+ N++ LD + E+++V + G L ++V + + + + + Sbjct: 74 RENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCREC 127 Query: 135 LRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD---EEMTGYVATRWYRAP 191 L+ L ++HS +IHRD+K N+ + D +++ DFG Q + + V T ++ AP Sbjct: 128 LQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAP 187 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 E++ Y VDIWS+G + E+++G+ + + + L I GTP + ++S Sbjct: 188 EVV-TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPELQNPERLS 245 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 + + D L R L +D D+R SA E L H + Sbjct: 246 A---------------------------VFRDFLNRCLEMDVDRRGSAKELLQHPFLK 276 >4UZD-A nrPDB Length = 287 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 76/292 (26%), Positives = 122/292 (41%), Gaps = 42/292 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQSLIHARRTYRELRLLKHLKH 80 + + RP+G G +G+V A + + + +A+K L + + + RE+ + HL+H Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRH 67 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTL--MGADLNNIVKCQALSDEHVQFLVYQLLRGL 138 N++ L F D + VYL+ +G + K ++ + +L L Sbjct: 68 PNILRLYGYF------HDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANAL 121 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRWYRAPEIMLNW 197 Y HS +IHRD+KP N+ + EL+I DFG + A T T Y PE++ Sbjct: 122 SYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR 181 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257 MH ++ VD+WS+G + E L GK F + Y + KRI V T Sbjct: 182 MH-DEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPD------------- 227 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 A DL+ R+L + QR E L H + + Sbjct: 228 ------------------FVTEGARDLISRLLKHNPSQRPMLREVLEHPWIT 261 >2JAM-A nrPDB Length = 304 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 71/297 (23%), Positives = 123/297 (41%), Gaps = 42/297 (14%) Query: 19 EVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL 78 + + + +GSGA+ V + A+K + + E+ +LK + Sbjct: 6 NIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPA--FRDSSLENEIAVLKKI 63 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLR 136 KHEN++ L D++ T YLV L+ G + I++ +++ ++ Q+L Sbjct: 64 KHENIVTLEDIYESTT------HYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLS 117 Query: 137 GLKYIHSAGIIHRDLKPSNVAV---NEDCELRILDFGLARQADEE-MTGYVATRWYRAPE 192 +KY+H GI+HRDLKP N+ E+ ++ I DFGL++ M+ T Y APE Sbjct: 118 AVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPE 177 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 ++ Y++ VD WS+G I LL G F ++I E I Sbjct: 178 VLA-QKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDI-- 234 Query: 253 EHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 + A D + +L D ++R + +AL+H + Sbjct: 235 -------------------------SESAKDFICHLLEKDPNERYTCEKALSHPWID 266 >4D28-A nrPDB Length = 446 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 63/298 (21%), Positives = 120/298 (40%), Gaps = 43/298 (14%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKHE 81 + + R +G G + V A + VA+K +++ + RE+ ++K ++H Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLK 139 N++ L +V + S++Y+V + G + IV L ++ + QL+ + Sbjct: 70 NIVRLYEV------LASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVA 123 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLA---RQADEEMTGYVATRWYRAPEIMLN 196 + HS G+ HRDLKP N+ ++ + L++ DFGL+ ++ E + T Y APE++ Sbjct: 124 HCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSG 183 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHAR 256 + DIWS G I+ +L G F +D ++I P Sbjct: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPP------------ 231 Query: 257 TYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 314 + L+ R+L + R+ +F + + P Sbjct: 232 -------------------WFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRKNYVP 270 >6C9D-A nrPDB Length = 459 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 63/314 (20%), Positives = 127/314 (40%), Gaps = 41/314 (13%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 + + +G G + V A ++VAVK + + + ++ +RE+R++K L H N Sbjct: 22 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 81 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKY 140 ++ L +V IE +YLV G + +V + ++ + Q++ ++Y Sbjct: 82 IVKLFEV------IETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 135 Query: 141 IHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWM 198 H I+HRDLK N+ ++ D ++I DFG + + ++ + + Y APE+ Sbjct: 136 CHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKK 195 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 + VD+WS+G I+ L+ G F G + + +R++ Sbjct: 196 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY------------------ 237 Query: 259 IQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEP 318 +P D ++ + L +R S + + + + H+ E+ Sbjct: 238 --RIPFYMSTDCENLLKKLLVLN-----------PIKRGSLEQIMKDRWMNVGHEEEELK 284 Query: 319 EAEPYDESVEAKER 332 D +R Sbjct: 285 PYTEPDPDFNDTKR 298 >4LG4-A nrPDB Length = 299 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 62/293 (21%), Positives = 123/293 (41%), Gaps = 45/293 (15%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 L +G G+YGSV A Q VA+K++ + +E+ +++ V Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE----SDLQEIIKEISIMQQCDSPYV 68 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNI--VKCQALSDEHVQFLVYQLLRGLKY 140 + + T ++++V G +++I ++ + L ++ + ++ L+GL+Y Sbjct: 69 VKYYGSYFKNT------DLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEY 122 Query: 141 IHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM---TGYVATRWYRAPEIMLNW 197 +H IHR++K N+ +N + ++ DFG+A Q + M + T ++ APE++ Sbjct: 123 LHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-QE 181 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257 + YN DIWS+G E+ +GK + I ++ I + P P Sbjct: 182 IGYNCVADIWSLGITSIEMAEGKPPYA---DIHPMRAIFMIPTNPPPTFRK--------- 229 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + D + + LV + +QR +A + L H + Sbjct: 230 ----------------PELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKN 266 >2HW6-A nrPDB Length = 307 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 80/315 (25%), Positives = 137/315 (43%), Gaps = 45/315 (14%) Query: 20 VPQRLQGL-----RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRL 74 +P + + + +G GAY V A + ++ AVK + + Q+ R +RE+ Sbjct: 6 LPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEK--QAGHSRSRVFREVET 63 Query: 75 LKHLK-HENVIGLLDVFTPATSIEDFSEVYLVTT-LMGAD-LNNIVKCQALSDEHVQFLV 131 L + ++N++ L++ F ED + YLV L G L +I K + ++ +V Sbjct: 64 LYQCQGNKNILELIEFF------EDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVV 117 Query: 132 YQLLRGLKYIHSAGIIHRDLKPSNVAVNED---CELRILDFGLARQA----------DEE 178 + L ++H+ GI HRDLKP N+ ++I DF L E Sbjct: 118 RDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPE 177 Query: 179 MTGYVATRWYRAPEIML----NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKR 234 +T + Y APE++ Y++ D+WS+G ++ +L G F G D Sbjct: 178 LTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD---- 233 Query: 235 IMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSD 294 G EV ++ + + P KD + I + A DL+ ++LV D+ Sbjct: 234 ----CGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHI----SSEAKDLISKLLVRDAK 285 Query: 295 QRVSAAEALAHAYFS 309 QR+SAA+ L H + Sbjct: 286 QRLSAAQVLQHPWVQ 300 >2YAB-A nrPDB Length = 361 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 79/332 (23%), Positives = 144/332 (43%), Gaps = 50/332 (15%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA----RRTYRELRLLKHLK 79 +GSG + V + + A K + + RE+ +L+ + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVL 73 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV-KCQALSDEHVQFLVYQLLRG 137 H N+I L DV+ E+ ++V L+ L+ G +L + + + ++LS+E + Q+L G Sbjct: 74 HPNIITLHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDC----ELRILDFGLARQADE--EMTGYVATRWYRAP 191 + Y+H+ I H DLKP N+ + + ++++DFGLA + ++ E T + AP Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 EI+ N+ D+WS+G I LL G + F G + L I V E ++ Sbjct: 188 EIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQ-- 244 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 + LA D + ++LV ++ +R++ EAL H + + Sbjct: 245 -------------------------TSELAKDFIRKLLVKETRKRLTIQEALRHPWIT-- 277 Query: 312 HDPEDEPEAEPYDESVEAKERTLEEWKELTYQ 343 P D +A ESV E +++ ++ Sbjct: 278 --PVDTQQAMVRRESVVNLENFKKQYVRRRWK 307 >5KCV-A nrPDB Length = 460 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 73/337 (21%), Positives = 136/337 (40%), Gaps = 54/337 (16%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQSLIHARRTYRELRLLKHLKH 80 + L+ +G G +G V + + A+K L + + T E R+L++ +H Sbjct: 162 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 221 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGL 138 + L F + V G ++ + + S++ +F +++ L Sbjct: 222 PFLTALKYSFQTH------DRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 275 Query: 139 KYIHS-AGIIHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYRAPEIM 194 Y+HS +++RDLK N+ +++D ++I DFGL ++ M + T Y APE++ Sbjct: 276 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 335 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRI-MEVVGTPSPEVLAKISSE 253 + Y + VD W +G +M E++ G+ F D+ + I ME + P Sbjct: 336 EDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----------- 383 Query: 254 HARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEALAHAYF 308 R P A LL +L D QR+ A E + H +F Sbjct: 384 ---------------------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 422 Query: 309 S--QYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQ 343 + + ++ + P+ V ++ T +E T Q Sbjct: 423 AGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQ 459 >3UDB-A nrPDB Length = 317 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 70/345 (20%), Positives = 133/345 (38%), Gaps = 44/345 (12%) Query: 11 QELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR 70 ++ + R + ++ +G+G +G D + + VAVK + R + R Sbjct: 8 GPMDLPIMHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKID---ENVKR 64 Query: 71 ELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQ 128 E+ + L+H N++ +V T + +V G I S++ + Sbjct: 65 EIINHRSLRHPNIVRFKEVILTPT------HLAIVMEYASGGELFERICNAGRFSEDEAR 118 Query: 129 FLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDC--ELRILDFGLARQ--ADEEMTGYVA 184 F QL+ G+ Y H+ + HRDLK N ++ L+I DFG ++ + V Sbjct: 119 FFFQQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVG 178 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSP 244 T Y APE++L + + D+WS G + +L G F + Sbjct: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEE---------------- 222 Query: 245 EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 K + + +P + +P L+ R+ V D +R+S E Sbjct: 223 ---PKNFRKTIHRILNVQYAIPD------YVHISPECRHLISRIFVADPAKRISIPEIRN 273 Query: 305 HAYFSQYHDPE---DEPEAEPYDESVEAKERTLEEWKELTYQEVL 346 H +F + + D +DES + + ++EE ++ + + Sbjct: 274 HEWFLKNLPADLMNDNTMTTQFDESDQPGQ-SIEEIMQIIAEATV 317 >4L42-A nrPDB Length = 346 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 83/361 (22%), Positives = 149/361 (41%), Gaps = 60/361 (16%) Query: 21 PQRLQGLRPVGSGAYGSVCSAYD---ARLRQKVAVKKLSRPF--QSLIHARRTYRELRLL 75 P+ + LR +G G YG V A + A+K L + ++ T E +L Sbjct: 17 PECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL 76 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQ 133 + +KH ++ L+ F ++YL+ + G + + ++ F + + Sbjct: 77 EEVKHPFIVDLIYAFQTGG------KLYLILEYLSGGELFMQLEREGIFMEDTACFYLAE 130 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT---GYVATRWYRA 190 + L ++H GII+RDLKP N+ +N +++ DFGL +++ + T + T Y A Sbjct: 131 ISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMA 190 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI 250 PEI++ H N+ VD WS+G +M ++L G F G + + +I++ Sbjct: 191 PEILMRSGH-NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC------------ 237 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEALAH 305 +LPP A DLL ++L ++ R+ A E AH Sbjct: 238 --------KLNLPPY-----------LTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAH 278 Query: 306 AYFSQYHDPEDEPEA--EPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSLEIE 363 +F + E P+ ++++E + + T Q P + P E E Sbjct: 279 PFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQ-----TPVDSPDDSTLSEEE 333 Query: 364 Q 364 Q Sbjct: 334 Q 334 >5D9K-A nrPDB Length = 330 Score = 244 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 80/339 (23%), Positives = 145/339 (42%), Gaps = 55/339 (16%) Query: 21 PQRLQGLRPVGSGAYGSVCSAYDA---RLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77 P + + L+ +G G++G V RQ A+K L + + RT E +L Sbjct: 29 PSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVE 88 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA-LSDEHVQFLVYQLL 135 + H ++ L F ++YL+ + G DL + + ++E V+F + +L Sbjct: 89 VNHPFIVKLHYAFQTEG------KLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 142 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYRAPE 192 L ++HS GII+RDLKP N+ ++E+ +++ DFGL++++ +++ + T Y APE Sbjct: 143 LALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPE 202 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME-VVGTPSPEVLAKIS 251 ++ N + Q+ D WS G +M E+L G F G D + + I++ +G P Sbjct: 203 VV-NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMP--------- 252 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSA-----AEALAHA 306 + +P A LL + + R+ A E H+ Sbjct: 253 -----------------------QFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHS 289 Query: 307 YFS--QYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQ 343 +FS ++ P+ + E T E T + Sbjct: 290 FFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAK 328 >2Y7J-A nrPDB Length = 365 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 80/332 (24%), Positives = 137/332 (41%), Gaps = 57/332 (17%) Query: 3 GPRAGFYRQELNKTV----W----EVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKK 54 Y Q + W E Q+ +G G V + AVK Sbjct: 67 KGTENLYFQSMGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKI 126 Query: 55 LSR------PFQSLIHARRTYRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTT 107 + P Q T RE +L+ + H ++I L+D + ++ ++LV Sbjct: 127 MEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSF------MFLVFD 180 Query: 108 LM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELR 165 LM G + + + ALS++ + ++ LL + ++H+ I+HRDLKP N+ ++++ ++R Sbjct: 181 LMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIR 240 Query: 166 ILDFGLARQA--DEEMTGYVATRWYRAPEIMLNWM-----HYNQTVDIWSVGCIMAELLQ 218 + DFG + E++ T Y APEI+ M Y + VD+W+ G I+ LL Sbjct: 241 LSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLA 300 Query: 219 GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGAN 278 G F I L+ IME S S + + Sbjct: 301 GSPPFWHRRQILMLRMIMEGQYQFS---------------------------SPEWDDRS 333 Query: 279 PLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 DL+ R+L +D + R++A +AL H +F + Sbjct: 334 STVKDLISRLLQVDPEARLTAEQALQHPFFER 365 >3GUB-A nrPDB Length = 295 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 81/326 (24%), Positives = 137/326 (42%), Gaps = 50/326 (15%) Query: 19 EVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA----RRTYRELRL 74 V +GSG + V + + A K + + RE+ + Sbjct: 8 NVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSI 67 Query: 75 LKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV-KCQALSDEHVQFLVY 132 LK ++H NVI L +V+ E+ ++V L+ L+ G +L + + + ++L++E + Sbjct: 68 LKEIQHPNVITLHEVY------ENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLK 121 Query: 133 QLLRGLKYIHSAGIIHRDLKPSNVAVNEDC----ELRILDFGLARQAD--EEMTGYVATR 186 Q+L G+ Y+HS I H DLKP N+ + + ++I+DFGLA + D E T Sbjct: 122 QILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTP 181 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEV 246 + APEI+ N+ D+WS+G I LL G + F G + L + V E Sbjct: 182 EFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDE- 239 Query: 247 LAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHA 306 F + LA D + R+LV D +R++ ++L H Sbjct: 240 --------------------------YFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHP 273 Query: 307 YFSQYHDPEDEPEAEPYDESVEAKER 332 + P+D +A S E+ Sbjct: 274 WIK----PKDTQQALSSAWSHPQFEK 295 >3DB8-A nrPDB Length = 317 Score = 244 bits (622), Expect = 7e-65, Method: Composition-based stats. Identities = 82/305 (26%), Positives = 135/305 (44%), Gaps = 44/305 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR-ELRLLKHLKH 80 +R R +G G + D ++ A K + + H + E+ + K L + Sbjct: 42 KRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDN 101 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLMG--ADLNNIVKCQALSDEHVQFLVYQLLRGL 138 +V+G F ED VY+V + + L + +A+++ ++ + Q ++G+ Sbjct: 102 PHVVGFHGFF------EDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGV 155 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYRAPEIML 195 +Y+H+ +IHRDLK N+ +N+D +++I DFGLA + E T Y APE++ Sbjct: 156 QYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLC 215 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 H + VDIWS+GCI+ LL GK F S + RI Sbjct: 216 KKGH-SFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRI-------------------- 254 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPE 315 +K+ S+ R NP+A L+ RML D R S AE L +F+ + P Sbjct: 255 -----------KKNEYSVPRHINPVASALIRRMLHADPTLRPSVAELLTDEFFTSGYAPM 303 Query: 316 DEPEA 320 P + Sbjct: 304 RLPTS 308 >6AO5-A nrPDB Length = 362 Score = 244 bits (622), Expect = 7e-65, Method: Composition-based stats. Identities = 62/293 (21%), Positives = 123/293 (41%), Gaps = 45/293 (15%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 L +G G+YGSV A Q VA+K++ + +E+ +++ V Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE----SDLQEIIKEISIMQQCDSPYV 67 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNI--VKCQALSDEHVQFLVYQLLRGLKY 140 + + T ++++V G +++I ++ + L ++ + ++ L+GL+Y Sbjct: 68 VKYYGSYFKNT------DLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEY 121 Query: 141 IHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM---TGYVATRWYRAPEIMLNW 197 +H IHR++K N+ +N + ++ DFG+A Q + M + T ++ APE++ Sbjct: 122 LHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-QE 180 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257 + YN DIWS+G E+ +GK + I ++ I + P P Sbjct: 181 IGYNCVADIWSLGITSIEMAEGKPPYA---DIHPMRAIFMIPTNPPPTFRK--------- 228 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + D + + LV + +QR +A + L H + Sbjct: 229 ----------------PELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKN 265 >3DAK-A nrPDB Length = 290 Score = 244 bits (622), Expect = 7e-65, Method: Composition-based stats. Identities = 75/313 (23%), Positives = 135/313 (43%), Gaps = 49/313 (15%) Query: 18 WEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLK 76 W + + + +GSGA V +AY A ++KVA+K+++ + +E++ + Sbjct: 5 WSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLE-KCQTSMDELLKEIQAMS 63 Query: 77 HLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKC---------QALSDEH 126 H N++ TS E++LV L+ G + +I+K L + Sbjct: 64 QCHHPNIVSYY------TSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDEST 117 Query: 127 VQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--------DEE 178 + ++ ++L GL+Y+H G IHRD+K N+ + ED ++I DFG++ ++ Sbjct: 118 IATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV 177 Query: 179 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 238 +V T + APE+M Y+ DIWS G EL G A + +K +M Sbjct: 178 RKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYH---KYPPMKVLMLT 234 Query: 239 VGTPSPEVLAKISSEHA-RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV 297 + P + + + + Y +S M + L D ++R Sbjct: 235 LQNDPPSLETGVQDKEMLKKYGKSFRKM-------------------ISLCLQKDPEKRP 275 Query: 298 SAAEALAHAYFSQ 310 +AAE L H +F + Sbjct: 276 TAAELLRHKFFQK 288 >2F57-A nrPDB Length = 317 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 75/330 (22%), Positives = 139/330 (42%), Gaps = 55/330 (16%) Query: 4 PRAGFYRQELNKTVWE-------------VPQRL-QGLRPVGSGAYGSVCSAYDARLRQK 49 R Y Q +++ E P+ +G G+ G VC A + ++ Sbjct: 13 GRENLYFQSMSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQ 72 Query: 50 VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM 109 VAVKK+ + + E+ +++ H+NV+ + + E+++V + Sbjct: 73 VAVKKMD--LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVG------DELWVVMEFL 124 Query: 110 -GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILD 168 G L +IV +++E + + +LR L Y+H+ G+IHRD+K ++ + D +++ D Sbjct: 125 EGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSD 184 Query: 169 FGLARQADEE---MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG 225 FG Q +E V T ++ APE++ + + Y VDIWS+G ++ E++ G+ + Sbjct: 185 FGFCAQVSKEVPKRKSLVGTPYWMAPEVI-SRLPYGTEVDIWSLGIMVIEMIDGEPPYFN 243 Query: 226 SDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLL 285 + ++RI + SLPP + + L Sbjct: 244 EPPLQAMRRIRD-----------------------SLPPR-----VKDLHKVSSVLRGFL 275 Query: 286 GRMLVLDSDQRVSAAEALAHAYFSQYHDPE 315 MLV + QR +A E L H + P Sbjct: 276 DLMLVREPSQRATAQELLGHPFLKLAGPPS 305 >2A27-A nrPDB Length = 321 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 80/326 (24%), Positives = 144/326 (44%), Gaps = 50/326 (15%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR----PFQSLIHARRTYRELRLLKHLK 79 +GSG + V + + A K + + + + RE+ +L+ + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV-KCQALSDEHVQFLVYQLLRG 137 H NVI L DV+ E+ ++V L+ L+ G +L + + + ++LS+E + Q+L G Sbjct: 74 HHNVITLHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDC----ELRILDFGLARQADE--EMTGYVATRWYRAP 191 + Y+H+ I H DLKP N+ + + ++++DFGLA + ++ E T + AP Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 EI+ N+ D+WS+G I LL G + F G + L I V E ++ Sbjct: 188 EIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQ-- 244 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 + LA D + ++LV ++ +R++ EAL H + + Sbjct: 245 -------------------------TSELAKDFIRKLLVKETRKRLTIQEALRHPWIT-- 277 Query: 312 HDPEDEPEAEPYDESVEAKERTLEEW 337 P D +A ESV E +++ Sbjct: 278 --PVDNQQAMVRRESVVNLENFRKQY 301 >4JXF-A nrPDB Length = 266 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 70/301 (23%), Positives = 128/301 (42%), Gaps = 45/301 (14%) Query: 17 VWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ-SLIHARRTYRELRLL 75 + E + + +G G++ V A +VA+K + + +R E+++ Sbjct: 2 IGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIH 61 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQ--ALSDEHVQFLVY 132 LKH +++ L + F ED + VYLV + ++N +K + S+ + ++ Sbjct: 62 CQLKHPSILELYNYF------EDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMH 115 Query: 133 QLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYR 189 Q++ G+ Y+HS GI+HRDL SN+ + + ++I DFGLA Q E+ T Y Sbjct: 116 QIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYI 175 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249 +PEI H D+WS+GC+ LL G+ F + L +++ Sbjct: 176 SPEIATRSAH-GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADY--------- 225 Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 + + A DL+ ++L + R+S + L H + S Sbjct: 226 ----------------------EMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMS 263 Query: 310 Q 310 + Sbjct: 264 R 264 >4PDS-A nrPDB Length = 347 Score = 242 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 80/300 (26%), Positives = 129/300 (43%), Gaps = 52/300 (17%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 VG GA+ +V A + + +VK +S+ + + + REL +L+ L H ++ L Sbjct: 37 EVVGQGAFATVKKAIERTTGKTFSVKIISKR-KVIGNMDGVTRELEVLQKLNHPRIVRLK 95 Query: 88 DVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA-LSDEHVQFLVYQLLRGLKYIHSAG 145 + ED Y+V + G DL + V + ++ + + Q+L +KYIHS G Sbjct: 96 GFY------EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMG 149 Query: 146 IIHRDLKPSNVAVNEDCEL--RILDFGLAR--QADEEMTGYVATRWYRAPEIMLN----- 196 I HRDLKP N+ + +D + +I FGLA+ M + T Y APE++ Sbjct: 150 ISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSV 209 Query: 197 -------WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249 Y+ VD+WS+GC++ +L G F GS K+I Sbjct: 210 SPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRG----------- 258 Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 S P KD + A D + +L +D + R +AA+AL H + Sbjct: 259 -----------SYHEGPLKDFR-----ISEEARDFIDSLLQVDPNNRSTAAKALNHPWIK 302 >1PHK-A nrPDB Length = 298 Score = 242 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 78/307 (25%), Positives = 125/307 (40%), Gaps = 50/307 (16%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT-------YRELRL 74 + + +G G V ++ AVK + A +E+ + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 75 LKHLK-HENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLV 131 L+ + H N+I L D + T +LV LM G + + + LS++ + ++ Sbjct: 77 LRKVSGHPNIIQLKDTYETNTF------FFLVFDLMKKGELFDYLTEKVTLSEKETRKIM 130 Query: 132 YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD--EEMTGYVATRWYR 189 LL + +H I+HRDLKP N+ +++D +++ DFG + Q D E++ T Y Sbjct: 131 RALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYL 190 Query: 190 APEIML-----NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSP 244 APEI+ N Y + VD+WS G IM LL G F + L+ IM Sbjct: 191 APEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFG- 249 Query: 245 EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 S + + DL+ R LV+ +R +A EALA Sbjct: 250 --------------------------SPEWDDYSDTVKDLVSRFLVVQPQKRYTAEEALA 283 Query: 305 HAYFSQY 311 H +F QY Sbjct: 284 HPFFQQY 290 >4KS7-A nrPDB Length = 292 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 70/291 (24%), Positives = 134/291 (46%), Gaps = 41/291 (14%) Query: 29 PVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 +G G+ G VC A + ++VAVK + + + E+ +++ +H NV+ + Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMD--LRKQQRRELLFNEVVIMRDYQHFNVVEMYK 87 Query: 89 VFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 + E++++ + G L +IV L++E + + +L+ L Y+H+ G+I Sbjct: 88 SYLVGE------ELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVI 141 Query: 148 HRDLKPSNVAVNEDCELRILDFGLARQADEE---MTGYVATRWYRAPEIMLNWMHYNQTV 204 HRD+K ++ + D +++ DFG Q ++ V T ++ APE++ + Y V Sbjct: 142 HRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL-YATEV 200 Query: 205 DIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPP 264 DIWS+G ++ E++ G+ + + +KR+ + +P P++ Sbjct: 201 DIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRD---SPPPKL------------------ 239 Query: 265 MPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPE 315 +P+ D L RMLV D +R +A E L H + Q PE Sbjct: 240 -------KNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPE 283 >1FOT-A nrPDB Length = 318 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 71/334 (21%), Positives = 140/334 (41%), Gaps = 48/334 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ-SLIHARRTYRELRLLKHLKH 80 Q Q LR +G+G++G V + A+K L + L T E +L + H Sbjct: 6 QDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTH 65 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV-KCQALSDEHVQFLVYQLLRGL 138 +I + F +D +++++ + G +L +++ K Q + +F ++ L Sbjct: 66 PFIIRMWGTF------QDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLAL 119 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWM 198 +Y+HS II+RDLKP N+ ++++ ++I DFG A+ + T Y APE++ + Sbjct: 120 EYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVV-STK 178 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 YN+++D WS G ++ E+L G F S+ + ++I+ P Sbjct: 179 PYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPP-------------- 224 Query: 259 IQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEALAHAYFSQ--Y 311 N DLL R++ D QR+ + H +F + + Sbjct: 225 -----------------FFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVW 267 Query: 312 HDPEDEPEAEPYDESVEAKERTLEEWKELTYQEV 345 PY+ ++ + ++ + +++ Sbjct: 268 EKLLSRNIETPYEPPIQQGQGDTSQFDKYPEEDI 301 >4B6L-A nrPDB Length = 281 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 77/304 (25%), Positives = 125/304 (41%), Gaps = 44/304 (14%) Query: 21 PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH-ARRTYRELRLLKHLK 79 + R +G G + A D AVK + + + H + E+ L + L+ Sbjct: 8 GRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQ 67 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVK-CQALSDEHVQFLVYQLLRG 137 H +++ + ED +Y+ L L +I K L + V++ + Q+L G Sbjct: 68 HRHIVRF------SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSG 121 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYRAPEIM 194 LKY+H GI+HRDLK N + E+ EL++ DFGLA + ++ T Y APE++ Sbjct: 122 LKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVL 181 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH 254 L H D+WS+GC+M LL G F +D + + I +V T Sbjct: 182 LRQGH-GPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLP----------- 229 Query: 255 ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 314 + A LL +L R S + L H +F++ + P Sbjct: 230 --------------------ASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTP 269 Query: 315 EDEP 318 + P Sbjct: 270 DRLP 273 >5D7A-A nrPDB Length = 308 Score = 240 bits (614), Expect = 6e-64, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 123/299 (41%), Gaps = 44/299 (14%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL-KHEN 82 + + VG+G YG V + Q A+K + +E+ +LK H N Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD---EEEEIKQEINMLKKYSHHRN 75 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGA----DLNNIVKCQALSDEHVQFLVYQLLRGL 138 + F +++LV GA DL K L +E + ++ ++LRGL Sbjct: 76 IATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGL 135 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD---EEMTGYVATRWYRAPEIML 195 ++H +IHRD+K NV + E+ E++++DFG++ Q D ++ T ++ APE++ Sbjct: 136 SHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 195 Query: 196 NWMH----YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 + Y+ D+WS+G E+ +G + ++ + + P+P + +K Sbjct: 196 CDENPDATYDFKSDLWSLGITAIEMAEGAPP---LCDMHPMRALFLIPRNPAPRLKSKKW 252 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 S+ ++ + LV + QR + + + H + Sbjct: 253 SKKFQS--------------------------FIESCLVKNHSQRPATEQLMKHPFIRD 285 >4FIE-A nrPDB Length = 423 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 71/291 (24%), Positives = 133/291 (45%), Gaps = 41/291 (14%) Query: 29 PVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 +G G+ G VC A + VAVKK+ + + E+ +++ +HENV+ + + Sbjct: 158 KIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVEMYN 215 Query: 89 VFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 + E+++V + G L +IV +++E + + +L+ L +H+ G+I Sbjct: 216 SYLVG------DELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVI 269 Query: 148 HRDLKPSNVAVNEDCELRILDFGLARQADEE---MTGYVATRWYRAPEIMLNWMHYNQTV 204 HRD+K ++ + D +++ DFG Q +E V T ++ APE +++ + Y V Sbjct: 270 HRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEV 328 Query: 205 DIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPP 264 DIWS+G ++ E++ G+ + + +K I + +LPP Sbjct: 329 DIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD-----------------------NLPP 365 Query: 265 MPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPE 315 + +P L R+LV D QR +AAE L H + ++ P Sbjct: 366 RLKN-----LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA 411 >3HKO-A nrPDB Length = 345 Score = 240 bits (613), Expect = 8e-64, Method: Composition-based stats. Identities = 87/367 (23%), Positives = 150/367 (40%), Gaps = 90/367 (24%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 61 S R Y Q ++ E+ ++ +G G+YG V A + + R A+K +++ Sbjct: 8 SSGRENLYFQ--GGSLLELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIR 65 Query: 62 LIHARRTYR---ELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV 117 I+ + R E+RL+K L H N+ L +V+ ED + LV L G L + + Sbjct: 66 QINPKDVERIKTEVRLMKKLHHPNIARLYEVY------EDEQYICLVMELCHGGHLLDKL 119 Query: 118 K-------------------------------------CQALS----DEHVQFLVYQLLR 136 ++L ++ + ++ Q+ Sbjct: 120 NVFIDDSTGKCAMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFS 179 Query: 137 GLKYIHSAGIIHRDLKPSNVAV--NEDCELRILDFGLARQADE-------EMTGYVATRW 187 L Y+H+ GI HRD+KP N N+ E++++DFGL+++ + MT T + Sbjct: 180 ALHYLHNQGICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPY 239 Query: 188 YRAPEIM-LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEV 246 + APE++ Y D WS G ++ LL G FPG + D + +++ Sbjct: 240 FVAPEVLNTTNESYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLN--------- 290 Query: 247 LAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHA 306 K+ E+ + +PLA DLL +L + D+R A AL H Sbjct: 291 -KKLCFENPN-----------------YNVLSPLARDLLSNLLNRNVDERFDAMRALQHP 332 Query: 307 YFSQYHD 313 + SQ+ D Sbjct: 333 WISQFSD 339 >2Q0N-A nrPDB Length = 301 Score = 240 bits (612), Expect = 9e-64, Method: Composition-based stats. Identities = 71/291 (24%), Positives = 133/291 (45%), Gaps = 41/291 (14%) Query: 29 PVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 +G G+ G VC A + VAVKK+ + + E+ +++ +HENV+ + + Sbjct: 36 KIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVEMYN 93 Query: 89 VFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 + E+++V + G L +IV +++E + + +L+ L +H+ G+I Sbjct: 94 SYLVG------DELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVI 147 Query: 148 HRDLKPSNVAVNEDCELRILDFGLARQADEE---MTGYVATRWYRAPEIMLNWMHYNQTV 204 HRD+K ++ + D +++ DFG Q +E V T ++ APE +++ + Y V Sbjct: 148 HRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEV 206 Query: 205 DIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPP 264 DIWS+G ++ E++ G+ + + +K I + +LPP Sbjct: 207 DIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD-----------------------NLPP 243 Query: 265 MPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPE 315 + +P L R+LV D QR +AAE L H + ++ P Sbjct: 244 RLKN-----LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA 289 >4JDH-A nrPDB Length = 346 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 71/291 (24%), Positives = 133/291 (45%), Gaps = 41/291 (14%) Query: 29 PVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 +G G+ G VC A + VAVKK+ + + E+ +++ +HENV+ + + Sbjct: 81 KIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVEMYN 138 Query: 89 VFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 + E+++V + G L +IV +++E + + +L+ L +H+ G+I Sbjct: 139 SYLVG------DELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVI 192 Query: 148 HRDLKPSNVAVNEDCELRILDFGLARQADEE---MTGYVATRWYRAPEIMLNWMHYNQTV 204 HRD+K ++ + D +++ DFG Q +E V T ++ APE +++ + Y V Sbjct: 193 HRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEV 251 Query: 205 DIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPP 264 DIWS+G ++ E++ G+ + + +K I + +LPP Sbjct: 252 DIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD-----------------------NLPP 288 Query: 265 MPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPE 315 + +P L R+LV D QR +AAE L H + ++ P Sbjct: 289 RLKN-----LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA 334 >4XBR-A nrPDB Length = 366 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 71/291 (24%), Positives = 133/291 (45%), Gaps = 41/291 (14%) Query: 29 PVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 +G G+ G VC A + VAVKK+ + + E+ +++ +HENV+ + + Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVEMYN 158 Query: 89 VFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 + E+++V + G L +IV +++E + + +L+ L +H+ G+I Sbjct: 159 SYLVG------DELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVI 212 Query: 148 HRDLKPSNVAVNEDCELRILDFGLARQADEE---MTGYVATRWYRAPEIMLNWMHYNQTV 204 HRD+K ++ + D +++ DFG Q +E V T ++ APE +++ + Y V Sbjct: 213 HRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEV 271 Query: 205 DIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPP 264 DIWS+G ++ E++ G+ + + +K I + +LPP Sbjct: 272 DIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD-----------------------NLPP 308 Query: 265 MPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPE 315 + +P L R+LV D QR +AAE L H + ++ P Sbjct: 309 RLKN-----LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA 354 >3TAC-A nrPDB Length = 361 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 80/316 (25%), Positives = 127/316 (40%), Gaps = 50/316 (15%) Query: 10 RQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR---PFQSLIHAR 66 R + + +G G + V + Q+ AVK + + Sbjct: 14 RGSMADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTE 73 Query: 67 RTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADL-NNIVKCQ---- 120 RE + LKH +++ LL+ ++ +Y+V M GADL IVK Sbjct: 74 DLKREASICHMLKHPHIVELLETYSSDGM------LYMVFEFMDGADLCFEIVKRADAGF 127 Query: 121 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAV---NEDCELRILDFGLARQADE 177 S+ + Q+L L+Y H IIHRD+KP V + +++ FG+A Q E Sbjct: 128 VYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGE 187 Query: 178 E---MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKR 234 G V T + APE++ Y + VD+W G I+ LL G F G+ +R Sbjct: 188 SGLVAGGRVGTPHFMAPEVV-KREPYGKPVDVWGCGVILFILLSGCLPFYGTK-----ER 241 Query: 235 IMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSD 294 + E + I+ M + S I + A DL+ RML+LD Sbjct: 242 LFEGI-------------------IKGKYKMNPRQWSHI----SESAKDLVRRMLMLDPA 278 Query: 295 QRVSAAEALAHAYFSQ 310 +R++ EAL H + + Sbjct: 279 ERITVYEALNHPWLKE 294 >3Q53-A nrPDB Length = 306 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 135/298 (45%), Gaps = 41/298 (13%) Query: 16 TVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLL 75 +V + ++ +G GA G+V +A D Q+VA+++++ Q E+ ++ Sbjct: 15 SVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMN--LQQQPKKELIINEILVM 72 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQL 134 + K+ N++ LD + E+++V + G L ++V + + + + + Sbjct: 73 RENKNPNIVNYLDSYLVG------DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCREC 126 Query: 135 LRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD---EEMTGYVATRWYRAP 191 L+ L+++HS +IHRD+K N+ + D +++ DFG Q + + V T ++ AP Sbjct: 127 LQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAP 186 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 E++ Y VDIWS+G + E+++G+ + + + L I GTP + K+S Sbjct: 187 EVV-TRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLI-ATNGTPELQNPEKLS 244 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 + + D L R L +D ++R SA E + H + Sbjct: 245 A---------------------------IFRDFLNRCLEMDVEKRGSAKELIQHQFLK 275 >2W4O-A nrPDB Length = 349 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 77/294 (26%), Positives = 120/294 (40%), Gaps = 46/294 (15%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 + +G GA V ++ A+K L + + + E+ +L L H N+ Sbjct: 55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKT----VDKKIVRTEIGVLLRLSHPNI 110 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYI 141 I L ++F T I LV L+ G + IV+ S+ V Q+L + Y+ Sbjct: 111 IKLKEIFETPTEIS------LVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYL 164 Query: 142 HSAGIIHRDLKPSNVAVNE---DCELRILDFGLARQADEE--MTGYVATRWYRAPEIMLN 196 H GI+HRDLKP N+ D L+I DFGL++ + + M T Y APEI+ Sbjct: 165 HENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRG 224 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID-QLKRIMEVVGTPSPEVLAKISSEHA 255 Y VD+WSVG I LL G F +RI+ ++S Sbjct: 225 CA-YGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLN-- 281 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 A DL+ +++VLD +R++ +AL H + + Sbjct: 282 -------------------------AKDLVRKLIVLDPKKRLTTFQALQHPWVT 310 >5J5T-A nrPDB Length = 370 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 77/382 (20%), Positives = 151/382 (39%), Gaps = 77/382 (20%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + + ++ +GSG YG V A + + A+K + +E+ ++K KH Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV--VQQEIIMMKDCKHP 61 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVK-CQALSDEHVQFLVYQLLRGLK 139 N++ + ++++ G L +I LS+ + ++ + L+GL Sbjct: 62 NIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLY 115 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD---EEMTGYVATRWYRAPEI--M 194 Y+HS G +HRD+K +N+ + ++ +++ DFG++ Q + ++ T ++ APE+ + Sbjct: 116 YLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAV 175 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH 254 YNQ D+W+VG EL + + + L + + P P++ K+ Sbjct: 176 ERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQP-PKLKDKMK--- 231 Query: 255 ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ---- 310 + + L + +R +A + L H + +Q Sbjct: 232 ----------------------WSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTR 269 Query: 311 -----------------YHD-PEDEPEA-EPYDESVEAKERTLEEWK---ELTYQEVLSF 348 YHD +D+PE + + R + E K E+T+ +V F Sbjct: 270 SLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQV-KF 328 Query: 349 KPP---------EPPKPPGSLE 361 PP E P G L+ Sbjct: 329 DPPLRKETEPHHELPDSDGFLD 350 >4CSV-A nrPDB Length = 275 Score = 237 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 126/299 (42%), Gaps = 50/299 (16%) Query: 16 TVWEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRL 74 WE+P+ + R +GSG +G V +VAVK L + + +E ++ Sbjct: 4 DKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLK---EGTMSVEEFLQEAQI 60 Query: 75 LKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKC---QALSDEHVQFL 130 +K LKH N++ L V T I Y++T M L + ++ ++ + + + Sbjct: 61 MKKLKHPNLVQLYGVCTKEPPI------YIITEYMSHGSLLDYLRDCEGHTVNAQALLDM 114 Query: 131 VYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE-MTGYVATRW-- 187 Q+ G+ Y+ S IHRDL N V E+ +++ DFGLAR +E+ T ++ Sbjct: 115 AAQVASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPI 174 Query: 188 -YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPE 245 + APE + ++ ++ D+W+ G ++ E+ G+ +PG + ++++ P P+ Sbjct: 175 KWTAPEAI-SYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQ 233 Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 G +L+ + ++R + AE L Sbjct: 234 ------------------------------GCPEEIYELMLQCWNKSPEERPTFAETLH 262 >2OU7-A nrPDB Length = 335 Score = 237 bits (605), Expect = 6e-63, Method: Composition-based stats. Identities = 87/321 (27%), Positives = 136/321 (42%), Gaps = 47/321 (14%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR-ELRLLKHLKHENVIGLLD 88 +G G + DA ++ A K + + H R E+ + + L H++V+G Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 89 VFTPATSIEDFSEVYLVTTLMG--ADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 F ED V++V L + L + +AL++ ++ + Q++ G +Y+H + Sbjct: 109 FF------EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 162 Query: 147 IHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYRAPEIMLNWMHYNQT 203 IHRDLK N+ +NED E++I DFGLA + E T Y APE++ H + Sbjct: 163 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH-SFE 221 Query: 204 VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLP 263 VD+WS+GCIM LL GK F S + RI Sbjct: 222 VDVWSIGCIMYTLLVGKPPFETSCLKETYLRI---------------------------- 253 Query: 264 PMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEP---EA 320 +K+ SI + NP+A L+ +ML D R + E L +F+ + P P Sbjct: 254 ---KKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLT 310 Query: 321 EPYDESVEAKERTLEEWKELT 341 P S+ K LT Sbjct: 311 IPPRFSIAPSSLDPSNRKPLT 331 >1ZWS-A nrPDB Length = 288 Score = 237 bits (604), Expect = 7e-63, Method: Composition-based stats. Identities = 77/309 (24%), Positives = 136/309 (44%), Gaps = 50/309 (16%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR----PFQSLIHARRTYRELRLLKHLK 79 +GSG + V + + A K + + + + RE+ +L+ + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV-KCQALSDEHVQFLVYQLLRG 137 H NVI L DV+ E+ ++V L+ L+ G +L + + + ++LS+E + Q+L G Sbjct: 74 HHNVITLHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDC----ELRILDFGLARQADE--EMTGYVATRWYRAP 191 + Y+H+ I H DLKP N+ + + ++++DFGLA + ++ E T + AP Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 EI+ N+ D+WS+G I LL G + F G + L I V E Sbjct: 188 EIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEF----- 241 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 F + LA D + ++LV ++ +R++ EAL H + + Sbjct: 242 ----------------------FSHTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT-- 277 Query: 312 HDPEDEPEA 320 P D +A Sbjct: 278 --PVDNQQA 284 >4I6B-A nrPDB Length = 308 Score = 237 bits (604), Expect = 8e-63, Method: Composition-based stats. Identities = 73/306 (23%), Positives = 129/306 (42%), Gaps = 44/306 (14%) Query: 21 PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTY-RELRLLKHLK 79 +R + +G G + D + A K + S H R +E+ L + L Sbjct: 27 GKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILH 86 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA-LSDEHVQFLVYQLLRG 137 H++V+ F ED +Y++ + +I+K + L++ V++ + Q++ G Sbjct: 87 HKHVVQFYHYF------EDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSG 140 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ---ADEEMTGYVATRWYRAPEIM 194 LKY+H I+HRDLK N +NE EL++ DFGLA + + T Y +PE++ Sbjct: 141 LKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL 200 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH 254 N + DIW++GC+M +L G+ F ++ + + I E T +LA Sbjct: 201 -NKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLA------ 253 Query: 255 ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 314 A L+ ML + + R S + + H +F+Q P Sbjct: 254 -------------------------PAKHLIASMLSKNPEDRPSLDDIIRHDFFTQGFTP 288 Query: 315 EDEPEA 320 + + Sbjct: 289 DRLSSS 294 >2Z7Q-A nrPDB Length = 321 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 76/333 (22%), Positives = 139/333 (41%), Gaps = 55/333 (16%) Query: 21 PQRLQGLRPVGSGAYGSVCSAYDAR---LRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77 P + L+ +G G++G V A+K L + + RT E +L Sbjct: 27 PSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILAD 86 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA-LSDEHVQFLVYQLL 135 + H V+ L F ++YL+ + G DL + + ++E V+F + +L Sbjct: 87 VNHPFVVKLHYAFQTEG------KLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 140 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYRAPE 192 GL ++HS GII+RDLKP N+ ++E+ +++ DFGL+++A +++ + T Y APE Sbjct: 141 LGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPE 200 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME-VVGTPSPEVLAKIS 251 ++ N ++ + D WS G +M E+L G F G D + + I++ +G P Sbjct: 201 VV-NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP--------- 250 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEALAHA 306 + + A LL + + R+ A E H Sbjct: 251 -----------------------QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV 287 Query: 307 YFS--QYHDPEDEPEAEPYDESVEAKERTLEEW 337 ++S ++ P+ +V + T Sbjct: 288 FYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFD 320 >3HDN-A nrPDB Length = 373 Score = 235 bits (601), Expect = 1e-62, Method: Composition-based stats. Identities = 72/340 (21%), Positives = 133/340 (39%), Gaps = 51/340 (15%) Query: 21 PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKL-SRPFQSLIHARRTYRELRLL-KHL 78 P L+ +G G++G V A AVK L + + E +L K++ Sbjct: 37 PSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNV 96 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLR 136 KH ++GL F A ++Y V + G ++ + + + +F ++ Sbjct: 97 KHPFLVGLHFSFQTA------DKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIAS 150 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR---QADEEMTGYVATRWYRAPEI 193 L Y+HS I++RDLKP N+ ++ + + DFGL + + + + + T Y APE+ Sbjct: 151 ALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEV 210 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSE 253 + + Y++TVD W +G ++ E+L G F + + I+ Sbjct: 211 L-HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKP-------------- 255 Query: 254 HARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA----EALAHAYFS 309 + A LL +L D +R+ A E +H +FS Sbjct: 256 -----------------LQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFS 298 Query: 310 --QYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLS 347 + D ++ P++ +V E T + V + Sbjct: 299 LINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPN 338 >4J52-A nrPDB Length = 293 Score = 235 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 82/295 (27%), Positives = 130/295 (44%), Gaps = 44/295 (14%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR-ELRLLKHLKHENVIGLLD 88 +G G + DA ++ A K + + H R E+ + + L H++V+G Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 89 VFTPATSIEDFSEVYLVTTLMG--ADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146 F ED V++V L + L + +AL++ ++ + Q++ G +Y+H + Sbjct: 82 FF------EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 135 Query: 147 IHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYRAPEIMLNWMHYNQT 203 IHRDLK N+ +NED E++I DFGLA + E T Y APE++ H + Sbjct: 136 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH-SFE 194 Query: 204 VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLP 263 VD+WS+GCIM LL GK F S + RI Sbjct: 195 VDVWSIGCIMYTLLVGKPPFETSCLKETYLRI---------------------------- 226 Query: 264 PMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEP 318 +K+ SI + NP+A L+ +ML D R + E L +F+ + P P Sbjct: 227 ---KKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLP 278 >4RLP-A nrPDB Length = 288 Score = 235 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 73/307 (23%), Positives = 131/307 (42%), Gaps = 53/307 (17%) Query: 21 PQRLQGLRPVGSGAYGSVCSAYD---ARLRQKVAVKKLSRPF--QSLIHARRTYRELRLL 75 P+ + LR +G G YG V A + A+K L + ++ T E +L Sbjct: 4 PECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL 63 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQ 133 + +KH ++ L+ F ++YL+ + G + + ++ F + + Sbjct: 64 EEVKHPFIVDLIYAFQTGG------KLYLILEYLSGGELFMQLEREGIFMEDTACFYLAE 117 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT---GYVATRWYRA 190 + L ++H GII+RDLKP N+ +N +++ DFGL +++ + T + T Y A Sbjct: 118 ISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMA 177 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI 250 PEI++ H N+ VD WS+G +M ++L G F G + + +I++ Sbjct: 178 PEILMRSGH-NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC------------ 224 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEALAH 305 +LPP A DLL ++L ++ R+ A E AH Sbjct: 225 --------KLNLPPY-----------LTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAH 265 Query: 306 AYFSQYH 312 +F + Sbjct: 266 PFFRHIN 272 >3UTO-A nrPDB Length = 573 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 77/362 (21%), Positives = 142/362 (39%), Gaps = 58/362 (16%) Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67 +Y Q + V +G+GA+G V + A K + P +S Sbjct: 143 YYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHES--DKET 200 Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV--KCQALSD 124 +E++ + L+H ++ L D F ED +E+ ++ M G +L V + +S+ Sbjct: 201 VRKEIQTMSVLRHPTLVNLHDAF------EDDNEMVMIYEFMSGGELFEKVADEHNKMSE 254 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN--EDCELRILDFGLARQADEEMTGY 182 + + Q+ +GL ++H +H DLKP N+ EL+++DFGL D + + Sbjct: 255 DEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVK 314 Query: 183 V--ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240 V T + APE+ D+WSVG + LL G + F G + + L+ + Sbjct: 315 VTTGTAEFAAPEVAEG-KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDW 373 Query: 241 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 300 S F G + D + ++L+ D + R++ Sbjct: 374 NMDD---------------------------SAFSGISEDGKDFIRKLLLADPNTRMTIH 406 Query: 301 EALAHAYFSQYHDPEDEPEAEP--YDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPG 358 +AL H + + + P + + Y + ++ + + W PEP P G Sbjct: 407 QALEHPWLTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAW-------------PEPLPPLG 453 Query: 359 SL 360 + Sbjct: 454 RI 455 >6FDY-U nrPDB Length = 276 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 72/299 (24%), Positives = 125/299 (41%), Gaps = 42/299 (14%) Query: 24 LQGLRPVGSGAYGSVCSAYDAR-LRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 +GSG Y +V AY + R+ VA+K +++ + E+ +LK ++H + Sbjct: 13 FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPH 72 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA-LSDEHVQFLVYQLLRGLKY 140 ++ L D D +YL+ G DL+ + + L ++ + + QL L++ Sbjct: 73 IVQLKDF------QWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQF 126 Query: 141 IHSAGIIHRDLKPSNVAVN--EDCELRILDFGLARQAD--EEMTGYVATRWYRAPEIMLN 196 +H I H DLKP N+ ++ E L++ DFG A+ +E + Y APE M+ Sbjct: 127 LHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPE-MVC 185 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHAR 256 Y+ VD+WS+G I+ E L G+ F + + ++I P Sbjct: 186 QRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELP------------ 233 Query: 257 TYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPE 315 + + DLL R+L D +R+S + AH + H P Sbjct: 234 ----------------LRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPS 276 >2X4F-A nrPDB Length = 373 Score = 234 bits (597), Expect = 4e-62, Method: Composition-based stats. Identities = 72/291 (24%), Positives = 129/291 (44%), Gaps = 43/291 (14%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 +G G +G V + K+A K + + + E+ ++ L H N+I L Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIK--TRGMKDKEEVKNEISVMNQLDHANLIQLY 152 Query: 88 DVFTPATSIEDFSEVYLVTTLM-GADLNNIV--KCQALSDEHVQFLVYQLLRGLKYIHSA 144 D F E +++ LV + G +L + + + L++ + Q+ G++++H Sbjct: 153 DAF------ESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQM 206 Query: 145 GIIHRDLKPSNVA-VNEDC-ELRILDFGLARQAD--EEMTGYVATRWYRAPEIMLNWMHY 200 I+H DLKP N+ VN D +++I+DFGLAR+ E++ T + APE++ N+ Sbjct: 207 YILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVV-NYDFV 265 Query: 201 NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQ 260 + D+WSVG I LL G + F G + + L I+ E I Sbjct: 266 SFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDI---------- 315 Query: 261 SLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 + A + + ++L+ + R+SA+EAL H + S + Sbjct: 316 -----------------SEEAKEFISKLLIKEKSWRISASEALKHPWLSDH 349 >5DBX-A nrPDB Length = 328 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 72/306 (23%), Positives = 127/306 (41%), Gaps = 48/306 (15%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 + +GSGA V +A +++VA+K+++ + +E++ + H NV Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLE-KCQTSMDELLKEIQAMSQCSHPNV 71 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVK---------CQALSDEHVQFLVYQ 133 + TS E++LV L+ G + +I+K L + + ++ + Sbjct: 72 VTYY------TSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKE 125 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--------DEEMTGYVAT 185 +L GL Y+H G IHRDLK N+ + ED ++I DFG++ ++ +V T Sbjct: 126 VLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGT 185 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245 + APE+M Y+ D+WS G EL G A + +K +M + P Sbjct: 186 PCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYH---KYPPMKVLMLTLQNDPPT 242 Query: 246 VLAKISSEH-ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 + + + + Y +S LL L D +R +AAE L Sbjct: 243 LETGVEDKEMMKKYGKSFRK-------------------LLSLCLQKDPSKRPTAAELLK 283 Query: 305 HAYFSQ 310 +F + Sbjct: 284 CKFFQK 289 >6CKI-A nrPDB Length = 316 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 78/312 (25%), Positives = 127/312 (40%), Gaps = 40/312 (12%) Query: 29 PVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK-HENVIGLL 87 +G GA+ V + + Q+ AVK + + + R +RE+ +L + H N Sbjct: 20 VLGEGAHARVQTCINLITSQEYAVKIIEKQPGHI--RSRVFREVEMLYQCQGHRN----- 72 Query: 88 DVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAG 145 V E+ YLV M G+ L++I K + ++ +V + L ++H+ G Sbjct: 73 -VLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKG 131 Query: 146 IIHRDLKPSNVAVNEDCE---LRILDFGLARQA----------DEEMTGYVATRWYRAPE 192 I HRDLKP N+ + ++I DFGL E+ + Y APE Sbjct: 132 IAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPE 191 Query: 193 IMLNWMH----YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLA 248 ++ + Y++ D+WS+G I+ LL G F G D G E Sbjct: 192 VVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSD--------CGWDRGEACP 243 Query: 249 KISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 + + + P KD + I A DL+ ++LV D+ QR+SAA+ L H + Sbjct: 244 ACQNMLFESIQEGKYEFPDKDWAHISCA----AKDLISKLLVRDAKQRLSAAQVLQHPWV 299 Query: 309 SQYHDPEDEPEA 320 P Sbjct: 300 QGCAPENTLPTP 311 >1U5R-A nrPDB Length = 348 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 80/354 (22%), Positives = 149/354 (42%), Gaps = 48/354 (13%) Query: 2 SGPRAGFYRQELNKTVW--EVPQRL-QGLRPVGSGAYGSVCSAYDARLRQKVAVKKLS-R 57 +G RAG + ++ + P++L LR +G G++G+V A D R + VA+KK+S Sbjct: 31 AGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYS 90 Query: 58 PFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV 117 QS + +E+R L+ L+H N I + + +LV ++++ Sbjct: 91 GKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTA------WLVMEYCLGSASDLL 144 Query: 118 --KCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA 175 + L + + + + L+GL Y+HS +IHRD+K N+ ++E +++ DFG A Sbjct: 145 EVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIM 204 Query: 176 DEEMTGYVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLK 233 +V T ++ APE++L + Y+ VD+WS+G EL + K ++ + Sbjct: 205 -APANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPP---LFNMNAMS 260 Query: 234 RIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDS 293 + + SP + + SE+ R + L Sbjct: 261 ALYHIAQNESPALQSGHWSEYFRN--------------------------FVDSCLQKIP 294 Query: 294 DQRVSAAEALAHAYFSQYHDP---EDEPEAEPYDESVEAKERTLEEWKELTYQE 344 R ++ L H + + P D + D E + K++ +QE Sbjct: 295 QDRPTSEVLLKHRFVLRERPPTVIMDLIQRTK-DAVRELDNLQYRKMKKILFQE 347 >6CMJ-A nrPDB Length = 321 Score = 234 bits (596), Expect = 7e-62, Method: Composition-based stats. Identities = 76/329 (23%), Positives = 143/329 (43%), Gaps = 53/329 (16%) Query: 3 GPRAGFYRQELNKTVWEVPQ-----RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR 57 G Y Q + ++ + + +G G+YG V AY+ A+K LS+ Sbjct: 10 GSAENLYFQGHHVSITGMQDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSK 69 Query: 58 P---------FQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTL 108 Q + Y+E+ +LK L H NV+ L++V + +Y+V L Sbjct: 70 KKLIRQAGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDP----NEDHLYMVFEL 125 Query: 109 MG-ADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRIL 167 + + + + LS++ +F L++G++Y+H IIHRD+KPSN+ V ED ++I Sbjct: 126 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 185 Query: 168 DFGLA---RQADEEMTGYVATRWYRAPEIMLNWMHY--NQTVDIWSVGCIMAELLQGKAL 222 DFG++ + +D ++ V T + APE + + +D+W++G + + G+ Sbjct: 186 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 245 Query: 223 FPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAI 282 F + +I H++ Q+L Q D++ Sbjct: 246 F----------------------MDERIMCLHSKIKSQALEFPDQPDIA-------EDLK 276 Query: 283 DLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 DL+ RML + + R+ E H + +++ Sbjct: 277 DLITRMLDKNPESRIVVPEIKLHPWVTRH 305 >4YNZ-A nrPDB Length = 342 Score = 234 bits (596), Expect = 7e-62, Method: Composition-based stats. Identities = 77/319 (24%), Positives = 131/319 (41%), Gaps = 45/319 (14%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 + + +G G G V QKVA+K ++R S + RE+ +LK ++H +V Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYI 141 + L DV+ E+ +YLV + G + +VK L+ + + Q++ L + Sbjct: 72 LKLHDVY------ENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFC 125 Query: 142 HSAGIIHRDLKPSNVAVNEDCELRILDFGLA--RQADEEMTGYVATRWYRAPEIMLNWMH 199 HS I HRDLKP N+ ++E +RI DFG+A + D + + Y PE++ + Sbjct: 126 HSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKY 185 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI 259 + D+WS G I+ LL G F + L+++ V Sbjct: 186 DGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPH--------------- 230 Query: 260 QSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPE 319 P LL M+ +D+ +R++ H + Y ++EPE Sbjct: 231 ----------------FIPPDCQSLLRGMIEVDAARRLTLEHIQKHIW---YIGGKNEPE 271 Query: 320 AE-PYDESVEAKERTLEEW 337 E P V+ + E Sbjct: 272 PEQPIPRKVQIRSLPSLED 290 >3TXO-A nrPDB Length = 353 Score = 233 bits (595), Expect = 9e-62, Method: Composition-based stats. Identities = 68/338 (20%), Positives = 124/338 (36%), Gaps = 53/338 (15%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQSLIHARRTYRELRLLKHLK- 79 + +R +G G++G V A AVK L + T E R+L + Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADL-NNIVKCQALSDEHVQFLVYQLLRG 137 H + L F ++ V + G DL +I K + + +F +++ Sbjct: 83 HPFLTQLFCCFQTP------DRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISA 136 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYRAPEIM 194 L ++H GII+RDLK NV ++ + ++ DFG+ ++ + T Y APEI+ Sbjct: 137 LMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEIL 196 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH 254 M Y VD W++G ++ E+L G A F + D + I+ Sbjct: 197 -QEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN----------------- 238 Query: 255 ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-SAAE-----ALAHAYF 308 D + A +L + + R+ S + L H +F Sbjct: 239 --------------DEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFF 284 Query: 309 SQ--YHDPEDEPEAEPYDESVEAKERTLEEWKELTYQE 344 + + P+ ++++E + +E Sbjct: 285 KEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEE 322 >2XIK-A nrPDB Length = 294 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 58/292 (19%), Positives = 123/292 (42%), Gaps = 42/292 (14%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 L +G G++G V D ++ VA+K + +E+ +L + Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIED-IQQEITVLSQCDSPYI 79 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 + +T +++++ +G +++K L + ++ ++ ++L+GL Y+H Sbjct: 80 TRYFGSYLKST------KLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLH 133 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE---EMTGYVATRWYRAPEIMLNWMH 199 S IHRD+K +NV ++E ++++ DFG+A Q + + +V T ++ APE++ Sbjct: 134 SERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-KQSA 192 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI 259 Y+ DIWS+G EL +G+ + + ++ + + P + + S Sbjct: 193 YDFKADIWSLGITAIELAKGEPP---NSDLHPMRVLFLIPKNSPPTLEGQHSKP------ 243 Query: 260 QSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 + + L D R +A E L H + ++Y Sbjct: 244 ---------------------FKEFVEACLNKDPRFRPTAKELLKHKFITRY 274 >4QMW-A nrPDB Length = 310 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 59/289 (20%), Positives = 117/289 (40%), Gaps = 42/289 (14%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 L +G G++G V D R ++ VA+K + +E+ +L V Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIED-IQQEITVLSQCDSPYV 89 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 + T +++++ +G ++++ L + + ++ ++L+GL Y+H Sbjct: 90 TKYYGSYLKDT------KLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLH 143 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE---EMTGYVATRWYRAPEIMLNWMH 199 S IHRD+K +NV ++E E+++ DFG+A Q + + +V T ++ APE++ Sbjct: 144 SEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-KQSA 202 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI 259 Y+ DIWS+G EL +G+ + +K + + P + S Sbjct: 203 YDSKADIWSLGITAIELARGEPP---HSELHPMKVLFLIPKNNPPTLEGNYSKP------ 253 Query: 260 QSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 + + L + R +A E L H + Sbjct: 254 ---------------------LKEFVEACLNKEPSFRPTAKELLKHKFI 281 >1KOA-A nrPDB Length = 491 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 77/362 (21%), Positives = 142/362 (39%), Gaps = 58/362 (16%) Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67 +Y Q + V +G+GA+G V + A K + P +S Sbjct: 37 YYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHES--DKET 94 Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV--KCQALSD 124 +E++ + L+H ++ L D F ED +E+ ++ M G +L V + +S+ Sbjct: 95 VRKEIQTMSVLRHPTLVNLHDAF------EDDNEMVMIYEFMSGGELFEKVADEHNKMSE 148 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN--EDCELRILDFGLARQADEEMTGY 182 + + Q+ +GL ++H +H DLKP N+ EL+++DFGL D + + Sbjct: 149 DEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVK 208 Query: 183 V--ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240 V T + APE+ D+WSVG + LL G + F G + + L+ + Sbjct: 209 VTTGTAEFAAPEVAEG-KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDW 267 Query: 241 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 300 S F G + D + ++L+ D + R++ Sbjct: 268 NMDD---------------------------SAFSGISEDGKDFIRKLLLADPNTRMTIH 300 Query: 301 EALAHAYFSQYHDPEDEPEAEP--YDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPG 358 +AL H + + + P + + Y + ++ + + W PEP P G Sbjct: 301 QALEHPWLTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAW-------------PEPLPPLG 347 Query: 359 SL 360 + Sbjct: 348 RI 349 >4U41-A nrPDB Length = 332 Score = 231 bits (590), Expect = 4e-61, Method: Composition-based stats. Identities = 68/332 (20%), Positives = 131/332 (39%), Gaps = 46/332 (13%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL-KHEN 82 + + VG+G YG V + Q A+K + E+ +LK H N Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEE---IKLEINMLKKYSHHRN 82 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGA----DLNNIVKCQALSDEHVQFLVYQLLRGL 138 + F + +++LV GA DL K L ++ + ++ ++LRGL Sbjct: 83 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 142 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD---EEMTGYVATRWYRAPEIML 195 ++H +IHRD+K NV + E+ E++++DFG++ Q D ++ T ++ APE++ Sbjct: 143 AHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 202 Query: 196 NWMH----YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 + Y+ D+WS G E+ +G + ++ + + P P + +K Sbjct: 203 CDENPDATYDYRSDLWSCGITAIEMAEGAPP---LCDMHPMRALFLIPRNPPPRLKSKKW 259 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 S+ ++ + LV + QR S + L H + Sbjct: 260 SKKFFSF--------------------------IEGCLVKNYMQRPSTEQLLKHPFIRD- 292 Query: 312 HDPEDEPEAEPYDESVEAKERTLEEWKELTYQ 343 P + + ++ + E E Y+ Sbjct: 293 -QPNERQVRIQLKDHIDRTRKKRGEKDETEYE 323 >5X8I-B nrPDB Length = 346 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 78/326 (23%), Positives = 141/326 (43%), Gaps = 46/326 (14%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLR-QKVAVKKLSRPFQSLIHARRTYRELRLLKHLK-- 79 R + + +G GA+G V D + + VAVK + + + E+++L+HL Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDR---YCEAARSEIQVLEHLNTT 70 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQAL---SDEHVQFLVYQLLR 136 N E + +V L+G + +K +H++ + YQ+ + Sbjct: 71 DPN--STFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICK 128 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNE-------------------DCELRILDFGLARQADE 177 + ++HS + H DLKP N+ + + +++++DFG A DE Sbjct: 129 SVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDE 188 Query: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME 237 + V+TR YRAPE++L + ++Q D+WS+GCI+ E G +FP D + L + Sbjct: 189 HHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMER 247 Query: 238 VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIF-RGANPL-------------AID 283 ++G P P+ + + + + + L R PL D Sbjct: 248 ILG-PLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFD 306 Query: 284 LLGRMLVLDSDQRVSAAEALAHAYFS 309 L+ +ML D +R++ EAL H +F Sbjct: 307 LIQKMLEYDPAKRITLREALKHPFFD 332 >2GCD-A nrPDB Length = 309 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 76/333 (22%), Positives = 140/333 (42%), Gaps = 46/333 (13%) Query: 21 PQRL-QGLRPVGSGAYGSVCSAYDARLRQKVAVKKLS-RPFQSLIHARRTYRELRLLKHL 78 P++L LR +G G++G+V A D R + VA+KK+S QS + +E+R L+ L Sbjct: 13 PEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL 72 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV--KCQALSDEHVQFLVYQLLR 136 +H N I + + +LV ++++ + L + + + + L+ Sbjct: 73 RHPNTIQYRGCYLREHTA------WLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQ 126 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIML- 195 GL Y+HS +IHRD+K N+ ++E +++ DFG A +V T ++ APE++L Sbjct: 127 GLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIM-APANSFVGTPYWMAPEVILA 185 Query: 196 -NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH 254 + Y+ VD+WS+G EL + K ++ + + + SP + + SE+ Sbjct: 186 MDEGQYDGKVDVWSLGITCIELAERKPP---LFNMNAMSALYHIAQNESPALQSGHWSEY 242 Query: 255 ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 314 R + L R ++ L H + + P Sbjct: 243 FRN--------------------------FVDSCLQKIPQDRPTSEVLLKHRFVLRERPP 276 Query: 315 ---EDEPEAEPYDESVEAKERTLEEWKELTYQE 344 D + D E + K++ +QE Sbjct: 277 TVIMDLIQRTK-DAVRELDNLQYRKMKKILFQE 308 >4FZF-B nrPDB Length = 283 Score = 230 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 56/291 (19%), Positives = 118/291 (40%), Gaps = 42/291 (14%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 L +G G++G V D R +Q VA+K + +E+ +L V Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIED-IQQEITVLSQCDSSYV 68 Query: 84 IGLLDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 + S+++++ +G ++++ + + ++ ++L+GL Y+H Sbjct: 69 TKYYGSYLKG------SKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLH 122 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE---EMTGYVATRWYRAPEIMLNWMH 199 S IHRD+K +NV ++E ++++ FG+A Q + + +V T ++ APE++ Sbjct: 123 SEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSA- 181 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI 259 Y+ DIWS+G EL +G+ + + ++ + + P ++ + Sbjct: 182 YDSKADIWSLGITAIELAKGEPP---NSDMHPMRVLFLIPKNNPPTLVGDFTKS------ 232 Query: 260 QSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + + L D R +A E L H + + Sbjct: 233 ---------------------FKEFIDACLNKDPSFRPTAKELLKHKFIVK 262 >6O6Q-A nrPDB Length = 335 Score = 230 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 86/319 (26%), Positives = 159/319 (49%), Gaps = 20/319 (6%) Query: 1 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 60 +S ++ + W + + LR +G G Y V D R+KV +K L Sbjct: 20 LSTKPQSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLK---- 75 Query: 61 SLIHARRTYRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC 119 + ++ RE+ +LK+L N+I +LDV S + + + D ++ Sbjct: 76 -PVKRKKIKREISILKNLVDGPNIIAMLDVVREPQS---KTPGLIFEHINNIDFRSL--Y 129 Query: 120 QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE-LRILDFGLAR--QAD 176 +D ++F +Y+LL+ L Y HS GI+HRD+KP NV ++ D + LR++D+GLA Sbjct: 130 PTFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPG 189 Query: 177 EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKAL-FPGSDYIDQLKRI 235 E VA+R+++ PE+++++ Y+ ++D+WS GC++A ++ K F G DQL +I Sbjct: 190 TEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQI 249 Query: 236 MEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRG-----ANPLAIDLLGRMLV 290 + V+G+ + + + + + + ++ + +DL+ R+L Sbjct: 250 VRVLGSKNFKKYLEKYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLR 309 Query: 291 LDSDQRVSAAEALAHAYFS 309 D +R++A EA+ HAYF Sbjct: 310 YDHQERLTAKEAMKHAYFD 328 >3LM0-A nrPDB Length = 327 Score = 230 bits (586), Expect = 8e-61, Method: Composition-based stats. Identities = 76/350 (21%), Positives = 141/350 (40%), Gaps = 55/350 (15%) Query: 4 PRAGFYRQELNKTVWEVPQRLQGL--RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 61 Y Q + L + +G G + V Q+ A K L + + Sbjct: 14 GTENLYFQSMENF-----NNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRG 68 Query: 62 LIHARRTYRELRLLKHLKH-ENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK-- 118 E+ +L+ K VI L +V+ + I + ++ G ++ ++ Sbjct: 69 QDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEI-----ILILEYAAGGEIFSLCLPE 123 Query: 119 -CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNE---DCELRILDFGLARQ 174 + +S+ V L+ Q+L G+ Y+H I+H DLKP N+ ++ +++I+DFG++R+ Sbjct: 124 LAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRK 183 Query: 175 ADE--EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQL 232 E+ + T Y APEI+ N+ D+W++G I LL + F G D + Sbjct: 184 IGHACELREIMGTPEYLAPEIL-NYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETY 242 Query: 233 KRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLD 292 I +V S E + + + LA D + +LV + Sbjct: 243 LNISQVNVDYSEETFSSV---------------------------SQLATDFIQSLLVKN 275 Query: 293 SDQRVSAAEALAHAYFSQY------HDPEDEPEAEPYDESVEAKERTLEE 336 ++R +A L+H++ Q+ H E ++ D SV + E + Sbjct: 276 PEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRSSEDKTSK 325 >2WO6-A nrPDB Length = 382 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 84/335 (25%), Positives = 151/335 (45%), Gaps = 48/335 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 R + +G G++G V AYD ++ VA+K + L A+ R L L+ KH+ Sbjct: 54 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMN--KHD 111 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC---QALSDEHVQFLVYQLLRGL 138 + + + + LV ++ +L ++++ + +S + Q+ L Sbjct: 112 TEMKYY-IVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTAL 170 Query: 139 KYIH--SAGIIHRDLKPSNVAVN--EDCELRILDFGLARQADEEMTGYVATRWYRAPEIM 194 ++ IIH DLKP N+ + + ++I+DFG + Q + + Y+ +R+YR+PE++ Sbjct: 171 LFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVL 230 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH 254 L M Y+ +D+WS+GCI+ E+ G+ LF G++ +DQ+ +I+EV+G P +L + + Sbjct: 231 LG-MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQ--APK 287 Query: 255 ARTYIQSLPP--MPQKDLSSIFRGANP--------------------------------- 279 AR + + LP K R P Sbjct: 288 ARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYL 347 Query: 280 LAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 314 DL+ RML D R+ AL H++F + D Sbjct: 348 KFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE 382 >2UV2-A nrPDB Length = 325 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 69/352 (19%), Positives = 139/352 (39%), Gaps = 56/352 (15%) Query: 4 PRAGFYRQELNKTVWEVPQRL------QGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR 57 Y Q + K V + L + + +G GA+G V A + A K + Sbjct: 14 GTENLYFQSM-KQYEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVID- 71 Query: 58 PFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGA---DLN 114 +S E+ +L H N++ LLD F + ++++ D Sbjct: 72 -TKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYE------NNLWILIEFCAGGAVDAV 124 Query: 115 NIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ 174 + + L++ +Q + Q L L Y+H IIHRDLK N+ D ++++ DFG++ + Sbjct: 125 MLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAK 184 Query: 175 AD---EEMTGYVATRWYRAPEIML----NWMHYNQTVDIWSVGCIMAELLQGKALFPGSD 227 + ++ T ++ APE+++ Y+ D+WS+G + E+ + + Sbjct: 185 NTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPP---HH 241 Query: 228 YIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGR 287 ++ ++ ++++ + P + SS F D L + Sbjct: 242 ELNPMRVLLKIAKSEPPTLAQ------------------PSRWSSNF-------KDFLKK 276 Query: 288 MLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKE 339 L + D R + ++ L H + + ++P E E+ +E+ KE Sbjct: 277 CLEKNVDARWTTSQLLQHPFVTV---DSNKPIRELIAEAKAEVTEEVEDGKE 325 >3KN6-A nrPDB Length = 325 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 69/304 (22%), Positives = 132/304 (43%), Gaps = 41/304 (13%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK-HENVIGL 86 +P+G G++ + Q AVK +S+ ++ T +E+ LK + H N++ L Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEA-----NTQKEITALKLCEGHPNIVKL 71 Query: 87 LDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSA 144 +VF D +LV L+ G I K + S+ +++ +L+ + ++H Sbjct: 72 HEVF------HDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDV 125 Query: 145 GIIHRDLKPSNVAV---NEDCELRILDFGLARQADEE---MTGYVATRWYRAPEIMLNWM 198 G++HRDLKP N+ N++ E++I+DFG AR + + T Y APE +LN Sbjct: 126 GVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE-LLNQN 184 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 Y+++ D+WS+G I+ +L G+ F D ++ A Sbjct: 185 GYDESCDLWSLGVILYTMLSGQVPFQSHD--------------------RSLTCTSAVEI 224 Query: 259 IQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEP 318 ++ + ++ + A DL+ +L +D ++R+ + + + P Sbjct: 225 MKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNP 284 Query: 319 EAEP 322 P Sbjct: 285 LMTP 288 >5X3F-B nrPDB Length = 393 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 70/344 (20%), Positives = 132/344 (38%), Gaps = 59/344 (17%) Query: 18 WEVP-------QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTY 69 WE P + ++ +G+G++G V A+K L + L T Sbjct: 73 WETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTL 132 Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHV 127 E R+L+ + ++ L S +D S +Y+V + G +++ + S+ H Sbjct: 133 NEKRILQAVNFPFLVKL------EFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHA 186 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW 187 +F Q++ +Y+HS +I+RDLKP N+ +++ +++ DFG A++ T Sbjct: 187 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPE 246 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 247 Y APEI+L+ YN+ VD W++G ++ E+ G F I ++I+ Sbjct: 247 YLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK-------- 297 Query: 248 AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEA 302 + DLL +L +D +R + Sbjct: 298 -----------------------VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDI 334 Query: 303 LAHAYFSQ------YHDPEDEPEAEPYDESVEAKERTLEEWKEL 340 H +F+ Y + P + + E +E+ Sbjct: 335 KNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEI 378 >1KOB-A nrPDB Length = 387 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 73/329 (22%), Positives = 135/329 (41%), Gaps = 55/329 (16%) Query: 3 GPRAGFYRQELNKTVWE--VPQR-----------LQGLRPVGSGAYGSVCSAYDARLRQK 49 GP+ Y + + +W+ VPQ L +GSGA+G V + + Sbjct: 20 GPKINDY-DKFYEDIWKKYVPQPVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKATGRV 78 Query: 50 VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM 109 K ++ P+ + E+ ++ L H +I L D F + V ++ L Sbjct: 79 FVAKFINTPY--PLDKYTVKNEISIMNQLHHPKLINLHDAFEDKYEM-----VLILEFLS 131 Query: 110 GADLNNIVKCQ--ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVA--VNEDCELR 165 G +L + + + +S+ V + Q GLK++H I+H D+KP N+ + ++ Sbjct: 132 GGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVK 191 Query: 166 ILDFGLARQA--DEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALF 223 I+DFGLA + DE + AT + APEI+ + D+W++G + LL G + F Sbjct: 192 IIDFGLATKLNPDEIVKVTTATAEFAAPEIV-DREPVGFYTDMWAIGVLGYVLLSGLSPF 250 Query: 224 PGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAID 283 G D ++ L+ + + + + +P A D Sbjct: 251 AGEDDLETLQNVKRCDWEFDEDAFSSV---------------------------SPEAKD 283 Query: 284 LLGRMLVLDSDQRVSAAEALAHAYFSQYH 312 + +L + +R++ +AL H + H Sbjct: 284 FIKNLLQKEPRKRLTVHDALEHPWLKGDH 312 >5F9E-A nrPDB Length = 353 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 75/328 (22%), Positives = 136/328 (41%), Gaps = 46/328 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPF-QSLIHARRTYRELRLLKHL-K 79 + + + +G G++G V A + Q A+K L + T E R+L + Sbjct: 19 EDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWE 78 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADL-NNIVKCQALSDEHVQFLVYQLLRGL 138 H + + F ++ +++ L G DL +I C F +++ GL Sbjct: 79 HPFLTHMFCTFQTKENL-----FFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGL 133 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ---ADEEMTGYVATRWYRAPEIML 195 +++HS GI++RDLK N+ +++D ++I DFG+ ++ D + + T Y APEI+L Sbjct: 134 QFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILL 193 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 YN +VD WS G ++ E+L G++ F G D + I Sbjct: 194 G-QKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI-------------------- 232 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA-EALAHAYFSQ--YH 312 + D R A DLL ++ V + ++R+ + H F + + Sbjct: 233 -----------RMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWE 281 Query: 313 DPEDEPEAEPYDESVEAKERTLEEWKEL 340 + E + P+ V++ KE Sbjct: 282 ELERKEIDPPFRPKVKSPFDCSNFDKEF 309 >6FYV-A nrPDB Length = 337 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 75/324 (23%), Positives = 138/324 (42%), Gaps = 42/324 (12%) Query: 23 RLQGLRPVGSGAYGSVCSAYDAR-LRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 R + + +G GA+G V D VAVK + + + E+++L+HL Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGR---YREAARSEIQVLEHLNST 71 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSD---EHVQFLVYQLLRGL 138 + + + V +V L+G + +K + +H++ + YQ+ + + Sbjct: 72 DPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSI 131 Query: 139 KYIHSAGIIHRDLKPSNVAVNE-------------------DCELRILDFGLARQADEEM 179 ++H + H DLKP N+ + + +++++DFG A DE Sbjct: 132 NFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHH 191 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVV 239 + V+TR YRAPE++L + ++Q D+WS+GCI+ E G +F D + L + ++ Sbjct: 192 STLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERIL 250 Query: 240 GTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRG--------------ANPLAIDLL 285 G P P+ + + + + + L R + DL+ Sbjct: 251 G-PIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLV 309 Query: 286 GRMLVLDSDQRVSAAEALAHAYFS 309 RML D QR++ EAL H +F Sbjct: 310 RRMLEYDPTQRITLDEALQHPFFD 333 >6ED6-A nrPDB Length = 415 Score = 227 bits (580), Expect = 5e-60, Method: Composition-based stats. Identities = 72/320 (22%), Positives = 126/320 (39%), Gaps = 42/320 (13%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKH 80 + ++ +G GA+G V ++ A+K LS+ + + E ++ Sbjct: 88 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 147 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLK 139 V+ L F +D +Y+V M G DL N++ + ++ +F +++ L Sbjct: 148 PWVVQLFYAF------QDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALD 201 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE----EMTGYVATRWYRAPEIML 195 IHS G+IHRD+KP N+ +++ L++ DFG + DE V T Y +PE++ Sbjct: 202 AIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLK 261 Query: 196 ---NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 Y + D WSVG + E+L G F + +IM+ + A+IS Sbjct: 262 SQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEIS- 320 Query: 253 EHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS--Q 310 +HA+ I + + L R E H +F Q Sbjct: 321 KHAKNLICAFLTDREVRLG------------------------RNGVEEIRQHPFFKNDQ 356 Query: 311 YHDPEDEPEAEPYDESVEAK 330 +H A P + + Sbjct: 357 WHWDNIRETAAPVVPELSSD 376 >5XVU-A nrPDB Length = 332 Score = 227 bits (578), Expect = 9e-60, Method: Composition-based stats. Identities = 87/319 (27%), Positives = 163/319 (51%), Gaps = 21/319 (6%) Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67 +Y + + W P R + ++ +G G Y V + YD + A + ++ Sbjct: 17 YYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA-----IKVLKPVKKKK 71 Query: 68 TYRELRLLKHLKH-ENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEH 126 RE+++L++L N+I LLD+ + + + + D + +D+ Sbjct: 72 IKREIKILQNLNGGPNIIKLLDIVKDPVT---KTPSLIFEYINNIDFKTL--YPKFTDKD 126 Query: 127 VQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLAR--QADEEMTGYV 183 +++ +YQ+L+ L Y HS GI+HRD+KP N+ ++ E+ ++R++ +GLA +E V Sbjct: 127 IRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRV 186 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKAL-FPGSDYIDQLKRIMEVVGTP 242 A+R+Y+ PE++++ Y+ ++DIWS+GC++A ++ K F G D DQL +I +V+GT Sbjct: 187 ASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTE 246 Query: 243 S-PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGAN-----PLAIDLLGRMLVLDSDQR 296 L K + + Y+ L +K S +N IDL+ +ML+ D +R Sbjct: 247 DLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKR 306 Query: 297 VSAAEALAHAYFSQYHDPE 315 ++ EA+ H YF + + Sbjct: 307 IAPKEAMEHPYFREVREES 325 >4WB7-A nrPDB Length = 405 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 70/344 (20%), Positives = 133/344 (38%), Gaps = 59/344 (17%) Query: 18 WEVP-------QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTY 69 WE P + + ++ +G+G++G V A+K L + L T Sbjct: 85 WESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTL 144 Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHV 127 E R+L+ + ++ L S +D S +Y+V + G +++ + S+ H Sbjct: 145 NEKRILQAVNFPFLVKL------EFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHA 198 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW 187 +F Q++ +Y+HS +I+RDLKP N+ +++ +++ DFG A++ T Sbjct: 199 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPE 258 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 247 Y APEI+L+ YN+ VD W++G ++ E+ G F I ++I+ Sbjct: 259 YLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK-------- 309 Query: 248 AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEA 302 + DLL +L +D +R + Sbjct: 310 -----------------------VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDI 346 Query: 303 LAHAYFSQ------YHDPEDEPEAEPYDESVEAKERTLEEWKEL 340 H +F+ Y + P + + E +E+ Sbjct: 347 KNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEI 390 >6E9W-A nrPDB Length = 443 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 61/256 (23%), Positives = 109/256 (42%), Gaps = 15/256 (5%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKH 80 + + ++ +G GA+G V R+ A+K LS+ + + E ++ Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 161 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLK 139 V+ L F +D +Y+V M G DL N++ + ++ +F +++ L Sbjct: 162 PWVVQLFYAF------QDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALD 215 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE----MTGYVATRWYRAPEIML 195 IHS G IHRD+KP N+ +++ L++ DFG + ++E V T Y +PE++ Sbjct: 216 AIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLK 275 Query: 196 ---NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 +Y + D WSVG + E+L G F + +IM + + IS Sbjct: 276 SQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISK 335 Query: 253 EHARTYIQSLPPMPQK 268 E L + Sbjct: 336 EAKNLICAFLTDREVR 351 >4GS6-A nrPDB Length = 315 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 77/327 (23%), Positives = 128/327 (39%), Gaps = 57/327 (17%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + ++ VG GA+G VC A + VA+K++ +S + ELR L + H Sbjct: 9 KEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQI----ESESERKAFIVELRQLSRVNHP 62 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKC----QALSDEHVQFLVYQLLR 136 N++ L + V LV G L N++ + H Q + Sbjct: 63 NIVKLYGACL--------NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQ 114 Query: 137 GLKYIHSAG---IIHRDLKPSNVAVNEDCEL-RILDFGLARQADEEMTGYVATRWYRAPE 192 G+ Y+HS +IHRDLKP N+ + + +I DFG A MT + + APE Sbjct: 115 GVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPE 174 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 + +Y++ D++S G I+ E++ + F + +G P+ ++ + + Sbjct: 175 VFEG-SNYSEKCDVFSWGIILWEVITRRKPF-------------DEIGGPAFRIMWAVHN 220 Query: 253 EHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAE---ALAHAYFS 309 I++LP + L+ R D QR S E + H Sbjct: 221 GTRPPLIKNLPKPIES---------------LMTRCWSKDPSQRPSMEEIVKIMTH--LM 263 Query: 310 QYHDPEDEPEAEPYDESVEAKERTLEE 336 +Y DEP P S+ E E Sbjct: 264 RYFPGADEPLQYPCQHSLPPGEDGRVE 290 >5YV8-A nrPDB Length = 298 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 73/319 (22%), Positives = 135/319 (42%), Gaps = 63/319 (19%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP----------------------- 58 + +G G+YG V AY+ A+K LS+ Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 59 -FQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNI 116 Q + Y+E+ +LK L H NV+ L++V + +Y+V L+ + + Sbjct: 73 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDP----NEDHLYMVFELVNQGPVMEV 128 Query: 117 VKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLA---R 173 + LS++ +F L++G++Y+H IIHRD+KPSN+ V ED ++I DFG++ + Sbjct: 129 PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK 188 Query: 174 QADEEMTGYVATRWYRAPEIMLNWMHY--NQTVDIWSVGCIMAELLQGKALFPGSDYIDQ 231 +D ++ V T + APE + + +D+W++G + + G+ F Sbjct: 189 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF-------- 240 Query: 232 LKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVL 291 + +I H++ Q+L Q D++ DL+ RML Sbjct: 241 --------------MDERIMCLHSKIKSQALEFPDQPDIA-------EDLKDLITRMLDK 279 Query: 292 DSDQRVSAAEALAHAYFSQ 310 + + R+ E H + ++ Sbjct: 280 NPESRIVVPEIKLHPWVTR 298 >1VZO-A nrPDB Length = 355 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 73/328 (22%), Positives = 145/328 (44%), Gaps = 49/328 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYD---ARLRQKVAVKKLSRP--FQSLIHARRTYRELRLLK 76 + + L+ +G+GAYG V + A+K L + Q T E ++L+ Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 77 HLK-HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLN-NIVKCQALSDEHVQFLVYQL 134 H++ ++ L F T + ++ + G +L ++ + + ++ VQ V ++ Sbjct: 114 HIRQSPFLVTLHYAFQTETKLH-----LILDYINGGELFTHLSQRERFTEHEVQIYVGEI 168 Query: 135 LRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA----DEEMTGYVATRWYRA 190 + L+++H GII+RD+K N+ ++ + + + DFGL+++ E + T Y A Sbjct: 169 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMA 228 Query: 191 PEIMLNW-MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249 P+I+ +++ VD WS+G +M ELL G + F + + Sbjct: 229 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF-------------------TVDGEKN 269 Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEALA 304 +E +R ++S PP PQ+ + LA DL+ R+L+ D +R+ A E Sbjct: 270 SQAEISRRILKSEPPYPQE--------MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKE 321 Query: 305 HAYFSQYHDPEDEPEAEPYDESVEAKER 332 H +F + + + + P ++ Sbjct: 322 HLFFQKINWDDLAAKKVPAPFKPVIRDE 349 >5DYK-A nrPDB Length = 853 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 78/327 (23%), Positives = 141/327 (43%), Gaps = 52/327 (15%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKL-SRPFQSLIHARRTYRELRLLKHLKH 80 L+ R +G G +G+V + + + A+K + R +L E + H Sbjct: 539 DELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDH 598 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNN-IVKCQALSDEHVQFLVYQLLRGL 138 +I L+ F +D Y +T L+ G +L + I K LS QF + ++ + Sbjct: 599 PFIIRLVRTF------KDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAI 652 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWM 198 +Y+H I++RDLKP N+ +++ ++++DFG A++ V T Y APE++L Sbjct: 653 EYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILG-K 711 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 Y TVDIW++G + E + G F G+D DQL+ +++ T Sbjct: 712 GYGCTVDIWALGICLYEFICGPLPF-GNDEEDQLEIFRDIL-----------------TG 753 Query: 259 IQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSA-----AEALAHAYFSQYH- 312 + P + +I+L+ R+L R+ + H +FS ++ Sbjct: 754 QLTFPDY----------VTDTDSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNW 803 Query: 313 --------DPEDEPEAEPYDESVEAKE 331 DP ++E Y E ++ K+ Sbjct: 804 DKLAGRLLDPPLVSKSETYAEDIDIKQ 830 >3ORZ-A nrPDB Length = 316 Score = 224 bits (570), Expect = 6e-59, Method: Composition-based stats. Identities = 71/315 (22%), Positives = 129/315 (40%), Gaps = 52/315 (16%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKL-SRPFQSLIHARRTYRELRLLKHLKH 80 + + + +G G++ +V A + ++ A+K L R RE ++ L H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGL 138 + L F +D ++Y + G L I K + + +F +++ L Sbjct: 97 PFFVKLYFCF------QDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSAL 150 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT-----GYVATRWYRAPEI 193 +Y+H GIIHRDLKP N+ +NED ++I DFG A+ E +V T Y +PE+ Sbjct: 151 EYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPEL 210 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSE 253 + ++ D+W++GCI+ +L+ G F + ++I+++ + Sbjct: 211 LTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFF------ 263 Query: 254 HARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAE------ALAHAY 307 P A DL+ ++LVLD+ +R+ E AH + Sbjct: 264 -------------------------PKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPF 298 Query: 308 FSQYHDPEDEPEAEP 322 F + P Sbjct: 299 FESVTWENLHQQTPP 313 >5N23-A nrPDB Length = 352 Score = 224 bits (570), Expect = 6e-59, Method: Composition-based stats. Identities = 70/345 (20%), Positives = 131/345 (37%), Gaps = 60/345 (17%) Query: 18 WEVP-------QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTY 69 WE P + + +R +G+G++G V A+K L + L T Sbjct: 31 WESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTL 90 Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHV 127 E R+ + + ++ L S +D S +Y+V G +++ + S+ H Sbjct: 91 NEKRIQQAVNFPFLVKL------EFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHA 144 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT-GYVATR 186 +F Q++ +Y+HS +I+RDLKP N+ +++ +++ DFG A++ T Sbjct: 145 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWTLCGTP 204 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEV 246 Y APEI+L+ YN+ VD W++G ++ E+ G F I ++I+ Sbjct: 205 EYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK------- 256 Query: 247 LAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAE 301 + DLL +L +D +R + Sbjct: 257 ------------------------VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVND 292 Query: 302 ALAHAYFSQ------YHDPEDEPEAEPYDESVEAKERTLEEWKEL 340 H +F+ Y + P + + E +E+ Sbjct: 293 IKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEI 337 >6F3F-A nrPDB Length = 455 Score = 223 bits (569), Expect = 8e-59, Method: Composition-based stats. Identities = 75/323 (23%), Positives = 129/323 (39%), Gaps = 55/323 (17%) Query: 10 RQELNKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT 68 Q L K WE+P+ L+ +G G +G V +VA+K L S Sbjct: 174 TQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMS---PEAF 229 Query: 69 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQA---LSD 124 +E +++K L+HE ++ L V + +Y+VT M L + +K + L Sbjct: 230 LQEAQVMKKLRHEKLVQLYAVVSEE-------PIYIVTEYMNKGSLLDFLKGETGKYLRL 282 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYV 183 + + Q+ G+ Y+ +HRDL+ +N+ V E+ ++ DFGLAR D E T Sbjct: 283 PQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 342 Query: 184 ATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVV 239 ++ + APE L + + D+WS G ++ EL G+ +PG + L ++ Sbjct: 343 GAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY 401 Query: 240 GTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSA 299 P P DL+ + + ++R + Sbjct: 402 RMPCP------------------------------PECPESLHDLMCQCWRKEPEERPTF 431 Query: 300 AEALAHAYFSQYHDPEDEPEAEP 322 E L A+ Y EP+ +P Sbjct: 432 -EYLQ-AFLEDYF-TSTEPQYQP 451 >2H8H-A nrPDB Length = 535 Score = 223 bits (569), Expect = 9e-59, Method: Composition-based stats. Identities = 75/323 (23%), Positives = 129/323 (39%), Gaps = 55/323 (17%) Query: 10 RQELNKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT 68 Q L K WE+P+ L+ +G G +G V +VA+K L S Sbjct: 254 TQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMS---PEAF 309 Query: 69 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQA---LSD 124 +E +++K L+HE ++ L V + +Y+VT M L + +K + L Sbjct: 310 LQEAQVMKKLRHEKLVQLYAVVSEE-------PIYIVTEYMSKGSLLDFLKGETGKYLRL 362 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYV 183 + + Q+ G+ Y+ +HRDL+ +N+ V E+ ++ DFGLAR D E T Sbjct: 363 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 422 Query: 184 ATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVV 239 ++ + APE L + + D+WS G ++ EL G+ +PG + L ++ Sbjct: 423 GAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY 481 Query: 240 GTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSA 299 P P DL+ + + ++R + Sbjct: 482 RMPCP------------------------------PECPESLHDLMCQCWRKEPEERPTF 511 Query: 300 AEALAHAYFSQYHDPEDEPEAEP 322 E L A+ Y EP+ +P Sbjct: 512 -EYLQ-AFLEDYF-TSTEPQYQP 531 >6HXF-B nrPDB Length = 302 Score = 222 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 65/311 (20%), Positives = 133/311 (42%), Gaps = 53/311 (17%) Query: 10 RQELN-KTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT 68 R++L+ VWE+ + +G GA+G V A + A K + +S Sbjct: 12 RRDLDPNEVWEI------VGELGDGAFGKVYKAKNKETGALAAAKVI--ETKSEEELEDY 63 Query: 69 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKC--QALSDE 125 E+ +L H ++ LL + +++++ G ++ I+ + L++ Sbjct: 64 IVEIEILATCDHPYIVKLLGAYY------HDGKLWIMIEFCPGGAVDAIMLELDRGLTEP 117 Query: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR---QADEEMTGY 182 +Q + Q+L L ++HS IIHRDLK NV + + ++R+ DFG++ + ++ + Sbjct: 118 QIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSF 177 Query: 183 VATRWYRAPEIM----LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 238 + T ++ APE++ + Y+ DIWS+G + E+ Q + ++ ++ ++++ Sbjct: 178 IGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPP---HHELNPMRVLLKI 234 Query: 239 VGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS 298 + P +L + D L L + + R S Sbjct: 235 AKSDPPTLLT-------------------------PSKWSVEFRDFLKIALDKNPETRPS 269 Query: 299 AAEALAHAYFS 309 AA+ L H + S Sbjct: 270 AAQLLEHPFVS 280 >5FET-A nrPDB Length = 847 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 86/355 (24%), Positives = 155/355 (43%), Gaps = 55/355 (15%) Query: 10 RQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKL-SRPFQSLIHARRT 68 R ++ T E+ + L+ R +G G +G+V + + + A+K + R SL Sbjct: 522 RIKMQDTKVEMHE-LETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNI 580 Query: 69 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNN-IVKCQALSDEH 126 E + H +I L+ F +D + Y +T L+ G +L + I K LS Sbjct: 581 KLEREITAENDHPFIIRLVRTF------KDSNCFYFLTELVTGGELYDAIRKLGLLSKPQ 634 Query: 127 VQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATR 186 QF + ++ ++Y+H I++RDLKP N+ +++ ++++DFG A++ V T Sbjct: 635 AQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTLVGTP 694 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEV 246 Y APE++L Y TVDIW++G + E + G F G+D DQL+ +++ Sbjct: 695 HYMAPEVILG-KGYGCTVDIWALGVCLYEFICGPLPF-GNDQEDQLEIFRDIL------- 745 Query: 247 LAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSA-----AE 301 T + P ++ +I+L+ R+L R+ + Sbjct: 746 ----------TGQLTFPDY----------VSDQDSINLMKRLLCRLPQGRIGCSINGFKD 785 Query: 302 ALAHAYFSQYH---------DPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLS 347 HA+F ++ +P + E Y E ++ K+ +EE L E L Sbjct: 786 IKEHAFFGNFNWDKLAGRLLEPPLVSKGETYAEDIDIKQ--IEEEDALNEGEPLD 838 >4WNO-A nrPDB Length = 287 Score = 220 bits (562), Expect = 6e-58, Method: Composition-based stats. Identities = 79/308 (25%), Positives = 133/308 (43%), Gaps = 54/308 (17%) Query: 19 EVPQRLQGLRP--VGSGAYGSVCSAYDARLRQ-KVAVKKLSRPFQSLIHARRTY-RELRL 74 E + + R +G GA+ V +VAVK +++ ++L ++ +E+++ Sbjct: 13 ETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINK--KNLAKSQTLLGKEIKI 70 Query: 75 LKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKC-QALSDEHVQFLVY 132 LK LKHEN++ L D A S VYLV G DL + + + LS++ ++ + Sbjct: 71 LKELKHENIVALYDFQEMANS------VYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQ 124 Query: 133 QLLRGLKYIHSAGIIHRDLKPSNVAVN---------EDCELRILDFGLARQADEEM--TG 181 Q+ ++ +HS GIIHRDLKP N+ ++ ++I DFG AR M Sbjct: 125 QIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT 184 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGT 241 + Y APE++++ HY+ D+WS+G I+ + L GKA F S D L+ E T Sbjct: 185 LCGSPMYMAPEVIMS-QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD-LRLFYEKNKT 242 Query: 242 PSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAE 301 P + + S+ + + L + R+ E Sbjct: 243 LVPTIPRETSAPLRQLLLALLQR---------------------------NHKDRMDFDE 275 Query: 302 ALAHAYFS 309 H + Sbjct: 276 FFHHPFLD 283 >4B8L-A nrPDB Length = 286 Score = 220 bits (562), Expect = 6e-58, Method: Composition-based stats. Identities = 66/301 (21%), Positives = 117/301 (38%), Gaps = 48/301 (15%) Query: 19 EVPQR------LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQSLIHARRTYRE 71 E+P+R RP+G G +G+V A + + + +A+K L + + + RE Sbjct: 6 EMPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRRE 65 Query: 72 LRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQF 129 + + HL+H N++ + + F D +YL+ G + K ++ Sbjct: 66 IEIQSHLRHPNILRMYNYF------HDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSAT 119 Query: 130 LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE-EMTGYVATRWY 188 + +L L Y H +IHRD+KP N+ + EL+I DFG + A T Y Sbjct: 120 FMEELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDY 179 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLA 248 PE++ H ++ VD+W G + E L G F + + +RI+ V P Sbjct: 180 LPPEMIEGKTH-DEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPP---- 234 Query: 249 KISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 + + DL+ ++L QR+ + H + Sbjct: 235 ---------------------------FLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWV 267 Query: 309 S 309 Sbjct: 268 K 268 >4RA4-A nrPDB Length = 355 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 75/344 (21%), Positives = 132/344 (38%), Gaps = 54/344 (15%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ-SLIHARRTYRELRLLKHLKHE 81 L +G G++G V A + A+K L + T E R+L L Sbjct: 21 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP 80 Query: 82 -NVIGLLDVFTPATSIEDFSEVYLVTTLM-GADL-NNIVKCQALSDEHVQFLVYQLLRGL 138 + L F + +Y V + G DL +I + + F ++ GL Sbjct: 81 PFLTQLHSCF------QTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGL 134 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYRAPEIML 195 ++H GII+RDLK NV ++ + ++I DFG+ ++ + T Y APEI+ Sbjct: 135 FFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIA 194 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 + Y ++VD W+ G ++ E+L G+ F G D + + IM EH Sbjct: 195 -YQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIM----------------EHN 237 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSA-----AEALAHAYFS- 309 +Y +SL + A+ + ++ +R+ + HA+F Sbjct: 238 VSYPKSL---------------SKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRR 282 Query: 310 -QYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPE 352 + E+ P+ V K E + + + PP+ Sbjct: 283 IDWEKLENREIQPPFKPKVSGK--GAENFDKFFTRGQPVLTPPD 324 >4CRL-A nrPDB Length = 406 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 100/346 (28%), Positives = 155/346 (44%), Gaps = 46/346 (13%) Query: 29 PVGSGAYGSVCSAYDARLRQK--VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 VG G YG V A + A+K++ S+ RE+ LL+ LKH NVI L Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMS----ACREIALLRELKHPNVISL 84 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA----------LSDEHVQFLVYQLLR 136 VF +V+L+ DL +I+K L V+ L+YQ+L Sbjct: 85 QKVFLS----HADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILD 140 Query: 137 GLKYIHSAGIIHRDLKPSNVAVN----EDCELRILDFGLARQADEEMTGY------VATR 186 G+ Y+H+ ++HRDLKP+N+ V E ++I D G AR + + V T Sbjct: 141 GIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTF 200 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD---------YIDQLKRIME 237 WYRAPE++L HY + +DIW++GCI AELL + +F + DQL RI Sbjct: 201 WYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFN 260 Query: 238 VVGTPSPEVLAKISS-EHARTYIQSLPPMPQKDLSSIFR------GANPLAIDLLGRMLV 290 V+G P+ + I T ++ + S I + A LL ++L Sbjct: 261 VMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLT 320 Query: 291 LDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEE 336 +D +R+++ +A+ YF + P + A + + T EE Sbjct: 321 MDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEE 366 >4APC-A nrPDB Length = 350 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 61/314 (19%), Positives = 123/314 (39%), Gaps = 52/314 (16%) Query: 4 PRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLI 63 Y Q + ++ L+ +G G++G ++ +K+++ S Sbjct: 14 GTENLYFQSM--------EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSK 65 Query: 64 HARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA- 121 + RE+ +L ++KH N++ + F E+ +Y+V G DL + Q Sbjct: 66 EREESRREVAVLANMKHPNIVQYRESF------EENGSLYIVMDYCEGGDLFKRINAQKG 119 Query: 122 --LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM 179 ++ + Q+ LK++H I+HRD+K N+ + +D +++ DFG+AR + + Sbjct: 120 VLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTV 179 Query: 180 ---TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 + T +Y +PEI N YN DIW++GC++ EL K F + + +I+ Sbjct: 180 ELARACIGTPYYLSPEICEN-KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKII 238 Query: 237 EVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQR 296 P + + L+ ++ + R Sbjct: 239 SGSFPP------------------------------VSLHYSYDLRSLVSQLFKRNPRDR 268 Query: 297 VSAAEALAHAYFSQ 310 S L + ++ Sbjct: 269 PSVNSILEKGFIAK 282 >5LOH-A nrPDB Length = 341 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 70/334 (20%), Positives = 123/334 (36%), Gaps = 49/334 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKH 80 + ++P+ GA+G V + AVK + + + + E L K Sbjct: 36 EEFSIVKPISRGAFGKVYLGQKG--GKLYAVKVVKKADMINKNMTHQVQAERDALALSKS 93 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVK-CQALSDEHVQFLVYQLLRGL 138 ++ L S++ + VYLV + G D+ +++ +E + ++ L Sbjct: 94 PFIVHLY------YSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALAL 147 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE---------EMTGYVATRWYR 189 Y+H GIIHRDLKP N+ ++ + +++ DFGL++ + T Y Sbjct: 148 DYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYL 207 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249 APE++L H VD W++G + E L G F + I++ P PE K Sbjct: 208 APELLLGRAH-GPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILK-RDIPWPEGEEK 265 Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 +S A + +L +D +R E H FS Sbjct: 266 LSDN---------------------------AQSAVEILLTIDDTKRAGMKELKRHPLFS 298 Query: 310 QYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQ 343 + + P+ + + T T Q Sbjct: 299 DVDWENLQHQTMPFIPQPDDETDTSYFEARNTAQ 332 >4C0T-A nrPDB Length = 974 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 76/324 (23%), Positives = 134/324 (41%), Gaps = 59/324 (18%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQSLIHARRTYRELRLLKHLKHE 81 + + +G G+Y +V A D ++ AVK L + + E L L + Sbjct: 267 DFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNR 326 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGLK 139 L V + + +D +Y V G L I + L++E + Q+L +K Sbjct: 327 -----LGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIK 381 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE------------MTGYVATRW 187 Y+H G+IHRDLKP N+ +++ ++I DFG AR +++ +V T Sbjct: 382 YMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAE 441 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 247 Y +PE++ N + + D+W+ GCI+ +++ GK F ++ ++I ++ Sbjct: 442 YVSPELLEN-KYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKL--------- 491 Query: 248 AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 Q S+ F DL+ ++LVL +R + E H + Sbjct: 492 -------------------QFAFSAGFPTI---IRDLIKKILVLQPSRRATIPEIQKHYF 529 Query: 308 FS--QYHDPE-----DEPEAEPYD 324 F + D + D PE PY Sbjct: 530 FQSVDFKDFDSIWLSDPPEIGPYK 553 >2WTK-C nrPDB Length = 305 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 75/330 (22%), Positives = 128/330 (38%), Gaps = 52/330 (15%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH--ARRTYRELRLLKHLKH 80 + +G G+YG V D+ + AVK L + I +E++LL+ L+H Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH 65 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC---QALSDEHVQFLVYQLLRG 137 +NVI L+DV E+ ++Y+V + ++ + QL+ G Sbjct: 66 KNVIQLVDVLYN----EEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDG 121 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-----DEEMTGYVATRWYRAPE 192 L+Y+HS GI+H+D+KP N+ + L+I G+A D+ + ++ PE Sbjct: 122 LEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPE 181 Query: 193 IMLNWMHYN-QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 I ++ VDIWS G + + G F G + + I + Sbjct: 182 IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSY----------- 230 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 +I P DLL ML + +R S + H++F + Sbjct: 231 --------------------AIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKK 270 Query: 312 HDPEDEPEAEPYDESVEAKERTLEEWKELT 341 H P + P P T + W+ +T Sbjct: 271 HPPAEAPVPIP------PSPDTKDRWRSMT 294 >3RAW-A nrPDB Length = 381 Score = 217 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 81/333 (24%), Positives = 138/333 (41%), Gaps = 42/333 (12%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQ-KVAVKKLSRPFQSLIHARRTYRELRLLKHL 78 + +R + + +G G +G V D + +VA+K + + + E+ +LK + Sbjct: 49 LQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGK---YREAARLEINVLKKI 105 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC---QALSDEHVQFLVYQLL 135 K ++ + + + L+G + +K Q HV+ + YQL Sbjct: 106 KEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLC 165 Query: 136 RGLKYIHSAGIIHRDLKPSNVAV-------------------NEDCELRILDFGLARQAD 176 L+++H + H DLKP N+ ++ +R+ DFG A Sbjct: 166 HALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDH 225 Query: 177 EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 E T VATR YR PE++L + + Q D+WS+GCI+ E +G LF + + L + Sbjct: 226 EHHTTIVATRHYRPPEVIL-ELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMME 284 Query: 237 EVVGTPSPEVLAKISSEHARTYIQSL-PPMPQKDLSSIFRGANPL-------------AI 282 +++G P P + + + Y L D + PL Sbjct: 285 KILG-PIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLF 343 Query: 283 DLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPE 315 DL+ RML D QR++ AEAL H +F+ E Sbjct: 344 DLMRRMLEFDPAQRITLAEALLHPFFAGLTPEE 376 >5SYS-A nrPDB Length = 286 Score = 217 bits (553), Expect = 6e-57, Method: Composition-based stats. Identities = 75/323 (23%), Positives = 128/323 (39%), Gaps = 55/323 (17%) Query: 10 RQELNKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT 68 Q L K WE+P+ L+ +G G +G +VA+K L S Sbjct: 5 TQGLAKDAWEIPRESLRLEVKLGQGCFGECWMGTWNGT-TRVAIKTLKPGTMS---PEAF 60 Query: 69 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKC---QALSD 124 +E +++K L+HE ++ L V + +Y+VT M L + +K + L Sbjct: 61 LQEAQVMKKLRHEKLVQLYAVVSEE-------PIYIVTEYMSKGSLLDFLKGEMGKYLRL 113 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYV 183 + + Q+ G+ Y+ +HRDL+ +N+ V E+ ++ DFGLAR D E T Sbjct: 114 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 173 Query: 184 ATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVV 239 ++ + APE L + + D+WS G ++ EL G+ +PG + L ++ Sbjct: 174 GAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY 232 Query: 240 GTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSA 299 P P DL+ + D ++R + Sbjct: 233 RMPCP------------------------------PECPESLHDLMCQCWRKDPEERPTF 262 Query: 300 AEALAHAYFSQYHDPEDEPEAEP 322 E L A+ Y EP+ +P Sbjct: 263 -EYLQ-AFLEDYF-TSTEPQYQP 282 >4MD7-E nrPDB Length = 391 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 90/316 (28%), Positives = 161/316 (50%), Gaps = 22/316 (6%) Query: 4 PRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLI 63 PR ++ E + W Q +R +G G Y V A + +K + + Sbjct: 20 PRE-YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPV 73 Query: 64 HARRTYRELRLLKHLKH-ENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQAL 122 ++ RE+++L++L+ N+I L D+ S + + + D + Q L Sbjct: 74 KKKKIKREIKILENLRGGPNIITLADIVKDPVS---RTPALVFEHVNNTDFKQL--YQTL 128 Query: 123 SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLAR--QADEEM 179 +D ++F +Y++L+ L Y HS GI+HRD+KP NV ++ E +LR++D+GLA +E Sbjct: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY 188 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKAL-FPGSDYIDQLKRIMEV 238 VA+R+++ PE+++++ Y+ ++D+WS+GC++A ++ K F G D DQL RI +V Sbjct: 189 NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKV 248 Query: 239 VGTPS-PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRG-----ANPLAIDLLGRMLVLD 292 +GT + + K + E + L +K +P A+D L ++L D Sbjct: 249 LGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYD 308 Query: 293 SDQRVSAAEALAHAYF 308 R++A EA+ H YF Sbjct: 309 HQSRLTAREAMEHPYF 324 >4XEY-B nrPDB Length = 408 Score = 217 bits (552), Expect = 9e-57, Method: Composition-based stats. Identities = 63/308 (20%), Positives = 119/308 (38%), Gaps = 50/308 (16%) Query: 5 RAGFYRQELNKTVWEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLI 63 + Y N WE+ + + +G G YG V + VAVK L + + Sbjct: 107 KPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTM 163 Query: 64 HARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVK---C 119 +E ++K +KH N++ LL V T Y++T M +L + ++ Sbjct: 164 EVEEFLKEAAVMKEIKHPNLVQLLGVCTREPP------FYIITEFMTYGNLLDYLRECNR 217 Query: 120 QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEE 178 Q ++ + ++ Q+ ++Y+ IHRDL N V E+ +++ DFGL+R + Sbjct: 218 QEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT 277 Query: 179 MTGYVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKR 234 T + ++ + APE + + ++ D+W+ G ++ E+ G + +PG D + Sbjct: 278 YTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYEL 336 Query: 235 IMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSD 294 + + PE G +L+ + Sbjct: 337 LEKDYRMERPE------------------------------GCPEKVYELMRACWQWNPS 366 Query: 295 QRVSAAEA 302 R S AE Sbjct: 367 DRPSFAEI 374 >2FO0-A nrPDB Length = 495 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 62/308 (20%), Positives = 119/308 (38%), Gaps = 50/308 (16%) Query: 5 RAGFYRQELNKTVWEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLI 63 + Y N WE+ + + +G G YG V + VAVK L + + Sbjct: 199 KPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTM 255 Query: 64 HARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVK---C 119 +E ++K +KH N++ LL V T Y++T M +L + ++ Sbjct: 256 EVEEFLKEAAVMKEIKHPNLVQLLGVCTREPP------FYIITEFMTYGNLLDYLRECNR 309 Query: 120 QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEE 178 Q ++ + ++ Q+ ++Y+ IHR+L N V E+ +++ DFGL+R + Sbjct: 310 QEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDT 369 Query: 179 MTGYVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKR 234 T + ++ + APE + + ++ D+W+ G ++ E+ G + +PG D + Sbjct: 370 YTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYEL 428 Query: 235 IMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSD 294 + + PE G +L+ + Sbjct: 429 LEKDYRMERPE------------------------------GCPEKVYELMRACWQWNPS 458 Query: 295 QRVSAAEA 302 R S AE Sbjct: 459 DRPSFAEI 466 >3A8W-A nrPDB Length = 345 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 70/345 (20%), Positives = 144/345 (41%), Gaps = 43/345 (12%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR-ELRLLKHL-K 79 Q LR +G G+Y V + + A+K + + + + E + + Sbjct: 9 QDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN 68 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADL-NNIVKCQALSDEHVQFLVYQLLRGL 138 H ++GL F + + +++ + G DL ++ + + L +EH +F ++ L Sbjct: 69 HPFLVGLHSCFQTESRL-----FFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLAL 123 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ---ADEEMTGYVATRWYRAPEIML 195 Y+H GII+RDLK NV ++ + +++ D+G+ ++ + + + T Y APEI+ Sbjct: 124 NYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILR 183 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 Y +VD W++G +M E++ G++ F ++VG+ ++ Sbjct: 184 G-EDYGFSVDWWALGVLMFEMMAGRSPF-------------DIVGSSDNP------DQNT 223 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSA------AEALAHAYFS 309 Y+ + Q I R + A +L L D +R+ A+ H +F Sbjct: 224 EDYLFQVILEKQIR---IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFR 280 Query: 310 --QYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPE 352 + E + P+ ++ + E L+ + E + P + Sbjct: 281 NVDWDMMEQKQVVPPFKPNI-SGEFGLDNFDSQFTNEPVQLTPDD 324 >2DQ7-X nrPDB Length = 283 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 78/318 (24%), Positives = 133/318 (41%), Gaps = 55/318 (17%) Query: 15 KTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELR 73 K VWE+P+ LQ ++ +G+G +G V KVA+K L S E + Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMS---PESFLEEAQ 56 Query: 74 LLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKC---QALSDEHVQF 129 ++K LKH+ ++ L V + +Y+VT M L + +K +AL ++ Sbjct: 57 IMKKLKHDKLVQLYAVVSEE-------PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVD 109 Query: 130 LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRW- 187 + Q+ G+ YI IHRDL+ +N+ V +I DFGLAR D E T ++ Sbjct: 110 MAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFP 169 Query: 188 --YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSP 244 + APE L + + D+WS G ++ EL+ G+ +PG + + L+++ P P Sbjct: 170 IKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCP 228 Query: 245 EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 + +L+ D ++R + E L Sbjct: 229 QD------------------------------CPISLHELMIHCWKKDPEERPTF-EYLQ 257 Query: 305 HAYFSQYHDPEDEPEAEP 322 ++ Y EP+ +P Sbjct: 258 -SFLEDYF-TATEPQYQP 273 >2XYN-A nrPDB Length = 292 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 69/321 (21%), Positives = 127/321 (39%), Gaps = 55/321 (17%) Query: 4 PRAGFYRQELNKTVWEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSL 62 Y Q ++K WE+ + + +G G YG V + VAVK L + Sbjct: 15 GTENLYFQSMDK--WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK---EDT 69 Query: 63 IHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVK--- 118 + +E ++K +KH N++ LL V T Y+VT M +L + ++ Sbjct: 70 MEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPP------FYIVTEYMPYGNLLDYLRECN 123 Query: 119 CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DE 177 + ++ + ++ Q+ ++Y+ IHRDL N V E+ +++ DFGL+R + Sbjct: 124 REEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGD 183 Query: 178 EMTGYVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLK 233 T + ++ + APE + + ++ D+W+ G ++ E+ G + +PG D Sbjct: 184 TYTAHAGAKFPIKWTAPESLA-YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYD 242 Query: 234 RIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDS 293 + + PE G P +L+ Sbjct: 243 LLEKGYRMEQPE------------------------------GCPPKVYELMRACWKWSP 272 Query: 294 DQRVSAAEALAH-AYFSQYHD 313 R S AE H A+ + +HD Sbjct: 273 ADRPSFAE--THQAFETMFHD 291 >6HMD-A nrPDB Length = 365 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 90/325 (27%), Positives = 165/325 (50%), Gaps = 21/325 (6%) Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67 ++ E + W Q +R +G G Y V A + + ++ + ++ Sbjct: 39 YWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNE-----RVVVKILKPVKKKK 93 Query: 68 TYRELRLLKHLKH-ENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEH 126 RE+++L++L+ N+I L+D S + + + D + Q L+D Sbjct: 94 IKREVKILENLRGGTNIIKLIDTVKDPVS---KTPALVFEYINNTDFKQL--YQILTDFD 148 Query: 127 VQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLARQAD--EEMTGYV 183 ++F +Y+LL+ L Y HS GI+HRD+KP NV ++ + +LR++D+GLA +E V Sbjct: 149 IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRV 208 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAEL-LQGKALFPGSDYIDQLKRIMEVVGTP 242 A+R+++ PE+++++ Y+ ++D+WS+GC++A + + + F G D DQL RI +V+GT Sbjct: 209 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTE 268 Query: 243 S-PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRG-----ANPLAIDLLGRMLVLDSDQR 296 L K + + L +K + +P A+DLL ++L D QR Sbjct: 269 ELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQR 328 Query: 297 VSAAEALAHAYFSQYHDPEDEPEAE 321 ++A EA+ H YF + +P A+ Sbjct: 329 LTAKEAMEHPYFYPVVKEQSQPSAD 353 >3NYO-A nrPDB Length = 576 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 76/315 (24%), Positives = 128/315 (40%), Gaps = 52/315 (16%) Query: 10 RQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR-RT 68 RQ + K + ++ R +G G +G VC+ + A KKL + Sbjct: 178 RQPVTKNTF---RQY---RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMA 231 Query: 69 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA---LSD 124 E ++L+ + V+ L A + E + LV TLM G DL + + Sbjct: 232 LNEKQILEKVNSRFVVSL------AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPE 285 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE--EMTGY 182 F ++ GL+ +H I++RDLKP N+ +++ +RI D GLA E + G Sbjct: 286 ARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR 345 Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTP 242 V T Y APE++ N Y + D W++GC++ E++ G++ F Sbjct: 346 VGTVGYMAPEVVKNER-YTFSPDWWALGCLLYEMIAGQSPFQQRK--------------- 389 Query: 243 SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV----- 297 KI E ++ +P + +P A L ++L D +R+ Sbjct: 390 -----KKIKREEVERLVKEVPEEYSERF-------SPQARSLCSQLLCKDPAERLGCRGG 437 Query: 298 SAAEALAHAYFSQYH 312 SA E H F + + Sbjct: 438 SAREVKEHPLFKKLN 452 >6QAU-A nrPDB Length = 280 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 74/308 (24%), Positives = 131/308 (42%), Gaps = 52/308 (16%) Query: 19 EVPQRLQGLRP--VGSGAYGSVCSAYDA-RLRQKVAVKKLSRPFQSLIHARRTYRELRLL 75 EV + + VG GA+ V + +VA+K +++ S +E+++L Sbjct: 6 EVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKIL 64 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA-LSDEHVQFLVYQ 133 K L+HEN++ L DV S V+LV G DL + ++ + LS++ ++ ++Q Sbjct: 65 KELQHENIVALYDVQELPNS------VFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQ 118 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVN---------EDCELRILDFGLARQADEEM--TGY 182 + ++ +HS GIIHRDLKP N+ ++ ++I DFG AR M Sbjct: 119 IAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADL 178 Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTP 242 + Y APE++++ HY+ D+WS+G ++ + L GK F + D L+ E + Sbjct: 179 CGSPMYMAPEVIMS-QHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD-LRMFYEKNRSL 236 Query: 243 SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEA 302 P + + S A + L + R+ Sbjct: 237 MPSIPRETSPYLANLLLGLL---------------------------QRNQKDRMDFEAF 269 Query: 303 LAHAYFSQ 310 +H + Q Sbjct: 270 FSHPFLEQ 277 >4AF3-A nrPDB Length = 292 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 70/291 (24%), Positives = 119/291 (40%), Gaps = 42/291 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQSLIHARRTYRELRLLKHLKH 80 + RP+G G +G+V A + + VA+K L + + + RE+ + HL H Sbjct: 23 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH 82 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQALSDEHVQFLVYQLLRGL 138 N++ L + F D +YL+ G + K ++ ++ +L L Sbjct: 83 PNILRLYNYFY------DRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADAL 136 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE-EMTGYVATRWYRAPEIMLNW 197 Y H +IHRD+KP N+ + EL+I DFG + A T Y PE++ Sbjct: 137 MYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGR 196 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257 MH N+ VD+W +G + ELL G F + + + +RI++V V Sbjct: 197 MH-NEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTG-------- 247 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 A DL+ ++L + +R+ A+ AH + Sbjct: 248 -----------------------AQDLISKLLRHNPSERLPLAQVSAHPWV 275 >6NPU-A nrPDB Length = 298 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 62/308 (20%), Positives = 120/308 (38%), Gaps = 50/308 (16%) Query: 5 RAGFYRQELNKTVWEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLI 63 +++ N WE+ + + +G G YG V + VAVK L + + Sbjct: 8 ENLYFQGSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTM 64 Query: 64 HARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVK---C 119 +E ++K +KH N++ LL V T Y++T M +L + ++ Sbjct: 65 EVEEFLKEAAVMKEIKHPNLVQLLGVCTREPP------FYIITEFMTYGNLLDYLRECNR 118 Query: 120 QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEE 178 Q ++ + ++ Q+ ++Y+ IHRDL N V E+ +++ DFGL+R + Sbjct: 119 QEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT 178 Query: 179 MTGYVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKR 234 T + ++ + APE + + ++ D+W+ G ++ E+ G + +PG D + Sbjct: 179 YTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYEL 237 Query: 235 IMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSD 294 + + PE G +L+ + Sbjct: 238 LEKDYRMERPE------------------------------GCPEKVYELMRACWQWNPS 267 Query: 295 QRVSAAEA 302 R S AE Sbjct: 268 DRPSFAEI 275 >3TKU-A nrPDB Length = 433 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 67/327 (20%), Positives = 125/327 (38%), Gaps = 48/327 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKH 80 + + ++ +G GA+G V + A+K L++ E +L + Sbjct: 90 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 149 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVT-TLMGADLNNIVKC--QALSDEHVQFLVYQLLRG 137 + + L F +D + +YLV +G DL ++ L ++ +F + +++ Sbjct: 150 QWITALHYAF------QDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLA 203 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY----VATRWYRAPEI 193 + IH +HRD+KP NV ++ + +R+ DFG + +++ T V T Y +PEI Sbjct: 204 IDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEI 263 Query: 194 ML----NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249 + Y D WS+G M E+L G+ F ++ +IM Sbjct: 264 LQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN------------ 311 Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV---SAAEALAHA 306 + S + A DL+ R L+ ++R+ + HA Sbjct: 312 --------------HEERFQFPSHVTDVSEEAKDLIQR-LICSRERRLGQNGIEDFKKHA 356 Query: 307 YFSQYHDPEDEPEAEPYDESVEAKERT 333 +F + PY V + T Sbjct: 357 FFEGLNWENIRNLEAPYIPDVSSPSDT 383 >3PFQ-A nrPDB Length = 674 Score = 214 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 74/344 (21%), Positives = 129/344 (37%), Gaps = 54/344 (15%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ-SLIHARRTYRELRLLKHL-KH 80 L +G G++G V + + AVK L + T E R+L K Sbjct: 342 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 401 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADL-NNIVKCQALSDEHVQFLVYQLLRGL 138 + L F +Y V + G DL +I + + H F ++ GL Sbjct: 402 PFLTQLHSCFQTM------DRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 455 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYRAPEIML 195 ++ S GII+RDLK NV ++ + ++I DFG+ ++ + T Y APEI+ Sbjct: 456 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 515 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 + Y ++VD W+ G ++ E+L G+A F G D + + IME Sbjct: 516 -YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHN---------------- 558 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSA-----AEALAHAYFS- 309 + + + A+ + ++ +R+ + HA+F Sbjct: 559 ---------------VAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 603 Query: 310 -QYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPE 352 + E + PY +A R E + + PP+ Sbjct: 604 IDWEKLERKEIQPPYKP--KASGRNAENFDRFFTRHPPVLTPPD 645 >6E2O-A nrPDB Length = 295 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 71/290 (24%), Positives = 128/290 (44%), Gaps = 44/290 (15%) Query: 29 PVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 +G G YG V + D + ++A+K++ P + +++ + E+ L KHLKH+N++ L Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKHLKHKNIVQYLG 86 Query: 89 VFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ----ALSDEHVQFLVYQLLRGLKYIHSA 144 F+ I+ F + + G L+ +++ + +++ + F Q+L GLKY+H Sbjct: 87 SFSENGFIKIF-----MEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDN 141 Query: 145 GIIHRDLKPSNVAVNE-DCELRILDFGLARQ---ADEEMTGYVATRWYRAPEIM-LNWMH 199 I+HRD+K NV +N L+I DFG +++ + + T Y APEI+ Sbjct: 142 QIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRG 201 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI 259 Y + DIWS+GC + E+ GK F +G P + Sbjct: 202 YGKAADIWSLGCTIIEMATGKPPFY-------------ELGEPQAAMFKVG-------MF 241 Query: 260 QSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 + P +P+ + A + + D D+R A + L + Sbjct: 242 KVHPEIPE--------SMSAEAKAFILKCFEPDPDKRACANDLLVDEFLK 283 >3FXW-A nrPDB Length = 336 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 69/357 (19%), Positives = 134/357 (37%), Gaps = 55/357 (15%) Query: 10 RQELNKTVWEVPQRLQGLR-PVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT 68 Q + V Q + +G G G V + R QK A+K L + + Sbjct: 16 FQGPEPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL-------YDSPKA 68 Query: 69 YRELRLLKHLKH------ENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA 121 +E+ H +++ +LDV+ + ++ M G +L + ++ + Sbjct: 69 RQEVD-----HHWQASGGPHIVCILDVYENMH--HGKRCLLIIMECMEGGELFSRIQERG 121 Query: 122 ---LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN---EDCELRILDFGLARQA 175 ++ ++ + ++++HS I HRD+KP N+ +D L++ DFG A++ Sbjct: 122 DQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKET 181 Query: 176 DEE-MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKR 234 + + T +Y APE++ Y+++ D+WS+G IM LL G F + Sbjct: 182 TQNALQTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTG------ 234 Query: 235 IMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSD 294 IS R P + S + + A L+ +L D Sbjct: 235 -------------QAISPGMKRRIRLGQYGFPNPEWSEV----SEDAKQLIRLLLKTDPT 277 Query: 295 QRVSAAEALAHAYFSQYHDPEDEP--EAEPYDESVEAKERTLEEWKELTYQEVLSFK 349 +R++ + + H + +Q P A E + + EE + + Sbjct: 278 ERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYD 334 >2PVN-A nrPDB Length = 352 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 84/319 (26%), Positives = 147/319 (46%), Gaps = 19/319 (5%) Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67 ++ E W + +R VG G Y V + + K + + + + + Sbjct: 38 YWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNE----KCIIKILKPVKKKKI 93 Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127 L N++ LLD+ S L+ + ++ L+D + Sbjct: 94 KREIKILQNLCGGPNIVKLLDIVRDQHSKTPS----LIFEYVNNTDFKVL-YPTLTDYDI 148 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE-LRILDFGLAR--QADEEMTGYVA 184 ++ +Y+LL+ L Y HS GI+HRD+KP NV ++ + LR++D+GLA +E VA Sbjct: 149 RYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVA 208 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKAL-FPGSDYIDQLKRIMEVVGTPS 243 +R+++ PE++++ Y+ ++D+WS+GC+ A ++ K F G D DQL +I +V+GT Sbjct: 209 SRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDG 268 Query: 244 -PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRG-----ANPLAIDLLGRMLVLDSDQRV 297 L K E + +K +P AID L ++L D +R+ Sbjct: 269 LNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERL 328 Query: 298 SAAEALAHAYFSQYHDPED 316 +A EA+ H YF Q E+ Sbjct: 329 TALEAMTHPYFQQVRAAEN 347 >5UNP-A nrPDB Length = 369 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 81/336 (24%), Positives = 144/336 (42%), Gaps = 54/336 (16%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQ-KVAVKKLSRPFQSLIHARRTYRELRLLKHL 78 + +R + + +G G +G V D R +VA+K + + + A R E+ +L+ + Sbjct: 32 LQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKII-KNVEKYKEAARL--EINVLEKI 88 Query: 79 K-----HENV-IGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ---ALSDEHVQF 129 ++N+ + + D F + + L+G + +K V+ Sbjct: 89 NEKDPDNKNLCVQMFDWFDYHG------HMCISFELLGLSTFDFLKDNNYLPYPIHQVRH 142 Query: 130 LVYQLLRGLKYIHSAGIIHRDLKPSNVA-VNEDCE------------------LRILDFG 170 + +QL + +K++H + H DLKP N+ VN D E +R++DFG Sbjct: 143 MAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFG 202 Query: 171 LARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID 230 A E + V+TR YRAPE++L + ++Q D+WS+GCI+ E G LF D + Sbjct: 203 SATFDHEHHSTIVSTRHYRAPEVIL-ELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNRE 261 Query: 231 QLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFR-GANPL--------- 280 L + ++G P P + + + + Y L R PL Sbjct: 262 HLAMMERILG-PIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAE 320 Query: 281 ----AIDLLGRMLVLDSDQRVSAAEALAHAYFSQYH 312 DL+ ML + +R++ EAL H +F++ Sbjct: 321 EHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLR 356 >6CQF-A nrPDB Length = 297 Score = 212 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 65/302 (21%), Positives = 125/302 (41%), Gaps = 43/302 (14%) Query: 13 LNKTVWEVPQR--LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR 70 ++ ++ R L+ +G G YG V A D VA+K + + + Sbjct: 5 VDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVK--MEPDDDVSTLQK 62 Query: 71 ELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVK-CQALSDEHVQ 128 E+ +LK +H N++ + ++++ G L +I + +LS+ + Sbjct: 63 EILILKTCRHANIVAYHGSYLW------LQKLWICMEFCGAGSLQDIYQVTGSLSELQIS 116 Query: 129 FLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT---GYVAT 185 ++ ++L+GL Y+HS IHRD+K +N+ +N+ E+R+ DFG++ Q + ++ T Sbjct: 117 YVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGT 176 Query: 186 RWYRAPEI--MLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPS 243 ++ APE+ + YN+ DIWS+G EL + + + L +M G Sbjct: 177 PYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLF-LMTKSGYQP 235 Query: 244 PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEAL 303 P + K + + + L +R SA + L Sbjct: 236 PRLKEKGK-------------------------WSAAFHNFIKVTLTKSPKKRPSATKML 270 Query: 304 AH 305 +H Sbjct: 271 SH 272 >3ALO-A nrPDB Length = 327 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 63/321 (19%), Positives = 119/321 (37%), Gaps = 46/321 (14%) Query: 18 WEV-PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLK 76 W+ + L+ L +G GAYGSV Q +AVK++ + +++ Sbjct: 17 WDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMR 76 Query: 77 HLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC------QALSDEHVQFL 130 ++ + ++ LM + K + +E + + Sbjct: 77 SSDCPYIVQFYGALFREG------DCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKI 130 Query: 131 VYQLLRGLKYIHSA-GIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVATRW 187 ++ L ++ IIHRD+KPSN+ ++ +++ DFG++ Q + T R Sbjct: 131 TLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRP 190 Query: 188 YRAPEIM---LNWMHYNQTVDIWSVGCIMAELLQGKALFPG-SDYIDQLKRIMEVVGTPS 243 Y APE + + Y+ D+WS+G + EL G+ +P + DQL ++++ Sbjct: 191 YMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKG----- 245 Query: 244 PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEAL 303 P + +S R +P I+ + L D +R E L Sbjct: 246 ---------------------DPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELL 284 Query: 304 AHAYFSQYHDPEDEPEAEPYD 324 H + Y + E Sbjct: 285 KHPFILMYEERAVEVACYVCK 305 >6EII-A nrPDB Length = 352 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 88/312 (28%), Positives = 159/312 (50%), Gaps = 21/312 (6%) Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67 ++ E + W Q +R +G G Y V A + +K + + ++ Sbjct: 46 YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVKKKK 100 Query: 68 TYRELRLLKHLKH-ENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEH 126 RE+++L++L+ N+I L D+ S + + + D + Q L+D Sbjct: 101 IKREIKILENLRGGPNIITLADIVKDPVS---RTPALVFEHVNNTDFKQL--YQTLTDYD 155 Query: 127 VQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLAR--QADEEMTGYV 183 ++F +Y++L+ L Y HS GI+HRD+KP NV ++ E +LR++D+GLA +E V Sbjct: 156 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRV 215 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKAL-FPGSDYIDQLKRIMEVVGTP 242 A+R+++ PE+++++ Y+ ++D+WS+GC++A ++ K F G D DQL RI +V+GT Sbjct: 216 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTE 275 Query: 243 S-PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRG-----ANPLAIDLLGRMLVLDSDQR 296 + + K + E + L +K +P A+D L ++L D R Sbjct: 276 DLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSR 335 Query: 297 VSAAEALAHAYF 308 ++A EA+ H YF Sbjct: 336 LTAREAMEHPYF 347 >2BRG-A nrPDB Length = 297 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 66/298 (22%), Positives = 123/298 (41%), Gaps = 42/298 (14%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 + ++ +G GAYG V A + + VAVK + +++ +E+ + K L Sbjct: 5 FVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK-RAVDCPENIKKEICINKMLN 63 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQ-ALSDEHVQFLVYQLLRG 137 HENV+ + + YL G +L + ++ + + Q +QL+ G Sbjct: 64 HENVVKFYG------HRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAG 117 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE-----MTGYVATRWYRAPE 192 + Y+H GI HRD+KP N+ ++E L+I DFGLA + T Y APE Sbjct: 118 VVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPE 177 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 ++ + + VD+WS G ++ +L G+ + PS Sbjct: 178 LLKRREFHAEPVDVWSCGIVLTAMLAGELPWD----------------QPSDSCQEYSDW 221 Query: 253 EHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + +TY+ + L+ LL ++LV + R++ + ++++ Sbjct: 222 KEKKTYLNPWKKIDSAPLA------------LLHKILVENPSARITIPDIKKDRWYNK 267 >6BDL-A nrPDB Length = 347 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 71/344 (20%), Positives = 132/344 (38%), Gaps = 52/344 (15%) Query: 22 QRLQGLRPVGSGAYGSVCSAY-DARLRQKVAVKKLSRP-FQSLIHARRTYRELRLLKHLK 79 + +G G +G V + + A+K L + E ++++ Sbjct: 34 SDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAH 93 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTT-LMGADLNNIVKCQA-LSDEHVQFLVYQLLRG 137 + ++ L F +D +Y++ +G +L I++ + D +F ++ Sbjct: 94 SDFIVRLYRTF------KDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEA 147 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--DEEMTGYVATRWYRAPEIML 195 Y+HS GII+RDLKP N+ ++ +++DFG A++ ++ + T Y APEI+L Sbjct: 148 FAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIIL 207 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 N H + + D WS+G +M ELL G F G D + I+ G E KI+ Sbjct: 208 NKGH-DISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILR--GIDMIEFPKKIAKN-- 262 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEALAHAYFS- 309 A +L+ ++ + +R+ + H +F Sbjct: 263 -------------------------AANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEG 297 Query: 310 -QYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPE 352 + P SV + T ++ E PP+ Sbjct: 298 FNWEGLRKGTLTPPIIPSVASPTDTSNFD---SFPEDNDEPPPD 338 >6GQK-A nrPDB Length = 328 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 76/337 (22%), Positives = 124/337 (36%), Gaps = 71/337 (21%) Query: 2 SGPRAGFYRQE---LNKTVWEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQ-----KVAV 52 S Y WE P+ RL + +G+GA+G V A L + VAV Sbjct: 17 SNGNNYSYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAV 76 Query: 53 KKLSRPFQSLIHARRTYRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGA 111 K L +P EL++L +L HEN++ LL T + + Sbjct: 77 KML-KPSAHSTEREALMSELKVLSYLGNHENIVNLLGACTHGGP-----TLVITEYCCYG 130 Query: 112 DLNNIVKCQA-----------------LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPS 154 DL N ++ + L+ EH+ YQ+ +G+ ++ S IHRDL Sbjct: 131 DLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAAR 190 Query: 155 NVAVNEDCELRILDFGLARQADEEMT------GYVATRWYRAPEIMLNWMHYNQTVDIWS 208 N+ + +I DFGLAR + + +W APE + N + Y D+WS Sbjct: 191 NILLTHGNITKICDFGLARDIKNDSNYVDKGNARLPVKW-MAPESIFNSV-YTFESDVWS 248 Query: 209 VGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQ 267 G + EL G + +PG + ++++ E S E+A Sbjct: 249 YGIFLWELFSLGSSPYPGMPVDSKFYKMIK-------EGFRMSSPEYAPA---------- 291 Query: 268 KDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 D++ D D+R + + + Sbjct: 292 ------------EMYDIMKTCWDADPDKRPTFKQIVQ 316 >2I0E-A nrPDB Length = 353 Score = 210 bits (536), Expect = 6e-55, Method: Composition-based stats. Identities = 74/344 (21%), Positives = 129/344 (37%), Gaps = 54/344 (15%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ-SLIHARRTYRELRLLKHL-KH 80 L +G G++G V + + AVK L + T E R+L K Sbjct: 21 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 80 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADL-NNIVKCQALSDEHVQFLVYQLLRGL 138 + L F +Y V + G DL +I + + H F ++ GL Sbjct: 81 PFLTQLHSCFQTM------DRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 134 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA---DEEMTGYVATRWYRAPEIML 195 ++ S GII+RDLK NV ++ + ++I DFG+ ++ + T Y APEI+ Sbjct: 135 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 194 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 + Y ++VD W+ G ++ E+L G+A F G D + + IME Sbjct: 195 -YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHN---------------- 237 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSA-----AEALAHAYFS- 309 + + + A+ + ++ +R+ + HA+F Sbjct: 238 ---------------VAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 282 Query: 310 -QYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPE 352 + E + PY +A R E + + PP+ Sbjct: 283 IDWEKLERKEIQPPYKP--KACGRNAENFDRFFTRHPPVLTPPD 324 >1NY3-A nrPDB Length = 400 Score = 210 bits (535), Expect = 7e-55, Method: Composition-based stats. Identities = 66/334 (19%), Positives = 132/334 (39%), Gaps = 45/334 (13%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLL-KHLKHENVIGL 86 + +G G G V ++ R ++K A+K L + RE+ L + + +++ + Sbjct: 68 QVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCPHIVRI 120 Query: 87 LDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA---LSDEHVQFLVYQLLRGLKYIH 142 +DV+ + + +V + G +L + ++ + ++ ++ + ++Y+H Sbjct: 121 VDVYENLYA--GRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 Query: 143 SAGIIHRDLKPSNVAVNE---DCELRILDFGLARQADEE--MTGYVATRWYRAPEIMLNW 197 S I HRD+KP N+ + L++ DFG A++ +T T +Y APE++ Sbjct: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GP 237 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257 Y+++ D+WS+G IM LL G F + + IS Sbjct: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-------------------AISPGMKTR 278 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDE 317 P + S + + L+ +L + QR++ E + H + Q Sbjct: 279 IRMGQYEFPNPEWSEV----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT 334 Query: 318 P--EAEPYDESVEAKERTLEEWKELTYQEVLSFK 349 P + E E E EE + ++ Sbjct: 335 PLHTSRVLKEDKERWEDVKEEMTSALATMRVDYE 368 >3VN9-A nrPDB Length = 340 Score = 210 bits (535), Expect = 7e-55, Method: Composition-based stats. Identities = 68/311 (21%), Positives = 131/311 (42%), Gaps = 48/311 (15%) Query: 12 ELNKTVWEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR 70 + +EV L+ + +G GAYG V Q +AVK++ S +R Sbjct: 40 SIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ-EQKRLLM 98 Query: 71 ELRL-LKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-----QALSD 124 +L + ++ + + +V++ LM L+ K Q + + Sbjct: 99 DLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDTSLDKFYKQVIDKGQTIPE 152 Query: 125 EHVQFLVYQLLRGLKYIHSA-GIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYV 183 + + + +++ L+++HS +IHRD+KPSNV +N ++++ DFG++ + + + Sbjct: 153 DILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTI 212 Query: 184 --ATRWYRAPEIM---LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 238 + Y APE + LN Y+ DIWS+G M EL + FP + +++ +V Sbjct: 213 DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQV 270 Query: 239 VGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS 298 V PSP++ A + +D + L +S +R + Sbjct: 271 VEEPSPQLPAD--------------------------KFSAEFVDFTSQCLKKNSKERPT 304 Query: 299 AAEALAHAYFS 309 E + H +F+ Sbjct: 305 YPELMQHPFFT 315 >4AW2-A nrPDB Length = 437 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 63/303 (20%), Positives = 117/303 (38%), Gaps = 48/303 (15%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKH 80 + + L+ +G GA+G V + A+K L++ E +L + Sbjct: 74 EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDS 133 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVT-TLMGADLNNIVKC--QALSDEHVQFLVYQLLRG 137 + + L F +D + +YLV +G DL ++ L +E +F + +++ Sbjct: 134 KWITTLHYAF------QDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIA 187 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY----VATRWYRAPEI 193 + +H +HRD+KP N+ ++ + +R+ DFG + E+ T V T Y +PEI Sbjct: 188 IDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEI 247 Query: 194 ML----NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249 + Y D WS+G M E+L G+ F ++ +IM Sbjct: 248 LQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN------------ 295 Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV---SAAEALAHA 306 + + + A DL+ R L+ + R+ + H Sbjct: 296 --------------HKERFQFPTQVTDVSENAKDLIRR-LICSREHRLGQNGIEDFKKHP 340 Query: 307 YFS 309 +FS Sbjct: 341 FFS 343 >3PPZ-A nrPDB Length = 309 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 60/328 (18%), Positives = 123/328 (37%), Gaps = 53/328 (16%) Query: 1 MSGPRAGFYRQELNKTVWEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPF 59 + +++ ++ ++P L +G+G++G+V A VAVK L Sbjct: 15 IPTTENLYFQGAMDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQD 72 Query: 60 QSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVK 118 RE+ ++K L+H N++ + T ++ +VT + L ++ Sbjct: 73 FHAERVNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLS------IVTEYLSRGSLYRLLH 126 Query: 119 ----CQALSDEHVQFLVYQLLRGLKYIHSAG--IIHRDLKPSNVAVNEDCELRILDFGLA 172 + L + + Y + +G+ Y+H+ I+HRDLK N+ V++ +++ DFGL+ Sbjct: 127 KSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLS 186 Query: 173 RQADEEM---TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYI 229 R T + APE++ + N+ D++S G I+ EL + + + Sbjct: 187 RLKASTFLSSKSAAGTPEWMAPEVLRD-EPSNEKSDVYSFGVILWELATLQQPWGNLNPA 245 Query: 230 DQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRML 289 +++ VG + I R NP ++ Sbjct: 246 ----QVVAAVGFKCKRL-------------------------EIPRNLNPQVAAIIEGCW 276 Query: 290 VLDSDQRV---SAAEALAHAYFSQYHDP 314 + +R + + L P Sbjct: 277 TNEPWKRPSFATIMDLLR-PLIKSAVPP 303 >2OZA-A nrPDB Length = 356 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 66/334 (19%), Positives = 132/334 (39%), Gaps = 45/334 (13%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLL-KHLKHENVIGL 86 + +G G G V ++ R ++K A+K L + RE+ L + + +++ + Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCPHIVRI 76 Query: 87 LDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA---LSDEHVQFLVYQLLRGLKYIH 142 +DV+ + + +V + G +L + ++ + ++ ++ + ++Y+H Sbjct: 77 VDVYENLYA--GRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 143 SAGIIHRDLKPSNVAVNE---DCELRILDFGLARQADEE--MTGYVATRWYRAPEIMLNW 197 S I HRD+KP N+ + L++ DFG A++ +T T +Y APE++ Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GP 193 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257 Y+++ D+WS+G IM LL G F + + IS Sbjct: 194 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-------------------AISPGMKTR 234 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDE 317 P + S + + L+ +L + QR++ E + H + Q Sbjct: 235 IRMGQYEFPNPEWSEV----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT 290 Query: 318 P--EAEPYDESVEAKERTLEEWKELTYQEVLSFK 349 P + E E E EE + ++ Sbjct: 291 PLHTSRVLKEDKERWEDVKEEMTSALATMRVDYE 324 >4FR4-A nrPDB Length = 384 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 126/298 (42%), Gaps = 40/298 (13%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKH 80 + LR +G G++G VC ++ A+K +++ R ++EL++++ L+H Sbjct: 15 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEH 74 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ-ALSDEHVQFLVYQLLRGLK 139 ++ L F ++ +V L+G DL ++ +E V+ + +L+ L Sbjct: 75 PFLVNLWYSFQ-----DEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALD 129 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM--TGYVATRWYRAPEIMLNW 197 Y+ + IIHRD+KP N+ ++E + I DF +A E T T+ Y APE+ + Sbjct: 130 YLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSR 189 Query: 198 M--HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 Y+ VD WS+G ELL+G+ + S E Sbjct: 190 KGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTS--------------------SKEIV 229 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS-AAEALAHAYFSQYH 312 T+ ++ P + + LL ++L + DQR S ++ Y + + Sbjct: 230 HTFETTVVTYPS--------AWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDIN 279 >6CCF-A nrPDB Length = 290 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 72/319 (22%), Positives = 132/319 (41%), Gaps = 63/319 (19%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR------------------------ 57 + + +G GAYG V AY+ + A+K LS+ Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 64 Query: 58 PFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNI 116 P + L+ R Y+E+ +LK L H NV+ L++V +YLV L+ + + Sbjct: 65 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPA----EDNLYLVFDLLRKGPVMEV 120 Query: 117 VKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA- 175 + S+E + + ++ GL+Y+H I+HRD+KPSN+ + +D ++I DFG++ Q Sbjct: 121 PCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 180 Query: 176 --DEEMTGYVATRWYRAPEIM--LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQ 231 D +++ T + APE + + +D+W+ G + + GK F D+I Sbjct: 181 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF-IDDFILA 239 Query: 232 LKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVL 291 L R ++ PE + DL+ +ML Sbjct: 240 LHRKIKNEPVVFPEE----------------------------PEISEELKDLILKMLDK 271 Query: 292 DSDQRVSAAEALAHAYFSQ 310 + + R+ + H + ++ Sbjct: 272 NPETRIGVPDIKLHPWVTK 290 >4IAN-A nrPDB Length = 358 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 88/341 (25%), Positives = 147/341 (43%), Gaps = 43/341 (12%) Query: 6 AGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYD-ARLRQKVAVKKLSRPFQSLIH 64 G+YR + + + +R G G + +V A D AR Q+VAVK + Sbjct: 17 EGYYRVNIGEV---LDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQ-- 71 Query: 65 ARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA--- 121 + +EL LK L + + LV + +L ++K Sbjct: 72 -KTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDV 130 Query: 122 -LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCEL-RILDFGLARQA-DEE 178 L + V+ QL LK + I+H D+KP N+ VNE + ++ DFG A D + Sbjct: 131 GLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND 190 Query: 179 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 238 +T Y+ +R+YRAPEI++ Y+ +D+WSVGC + EL GK LFPG LK M++ Sbjct: 191 ITPYLVSRFYRAPEIIIG-KSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDL 249 Query: 239 VGTPSPEVLAK------ISSEHARTYIQSLPPMPQKDLSSIFRGANP------------- 279 G +++ K ++ + + +++ ++ NP Sbjct: 250 KGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQR 309 Query: 280 ----------LAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 DLL ++L+LD +R+S +AL HA+ + Sbjct: 310 LPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 350 >3KA0-A nrPDB Length = 320 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 66/322 (20%), Positives = 129/322 (40%), Gaps = 45/322 (13%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLL-KHLKHENVIGL 86 + +G G G V ++ R ++K A+K L + RE+ L + + +++ + Sbjct: 22 QVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCPHIVRI 74 Query: 87 LDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA---LSDEHVQFLVYQLLRGLKYIH 142 +DV+ + + +V + G +L + ++ + ++ ++ + ++Y+H Sbjct: 75 VDVYENLYA--GRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 132 Query: 143 SAGIIHRDLKPSNVAVNE---DCELRILDFGLARQADEE--MTGYVATRWYRAPEIMLNW 197 S I HRD+KP N+ + L++ DFG A++ +T T +Y APE++ Sbjct: 133 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVL-GP 191 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257 Y+++ D+WS+G IM LL G F + + IS Sbjct: 192 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-------------------AISPGMKTR 232 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDE 317 P + S + + L+ +L + QR++ E + H + Q Sbjct: 233 IRMGQYEFPNPEWSEV----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT 288 Query: 318 P--EAEPYDESVEAKERTLEEW 337 P + E E E EE Sbjct: 289 PLHTSRVLKEDKERWEDVKEEM 310 >3FME-A nrPDB Length = 290 Score = 207 bits (527), Expect = 7e-54, Method: Composition-based stats. Identities = 66/300 (22%), Positives = 128/300 (42%), Gaps = 47/300 (15%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRL-LKHLKH 80 L+ + +G GAYG V Q +AVK++ S +R +L + ++ + Sbjct: 7 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ-EQKRLLMDLDISMRTVDC 65 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-----QALSDEHVQFLVYQLL 135 + +V++ LM L+ K Q + ++ + + ++ Sbjct: 66 PFTVTFYGALFREG------DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 119 Query: 136 RGLKYIHSA-GIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYV--ATRWYRAPE 192 + L+++HS +IHRD+KPSNV +N ++++ DFG++ +++ + + Y APE Sbjct: 120 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPE 179 Query: 193 IM---LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249 + LN Y+ DIWS+G M EL + FP + +++ +VV PSP++ A Sbjct: 180 RINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPSPQLPAD 237 Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 + +D + L +S +R + E + H +F+ Sbjct: 238 --------------------------KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 271 >2WQN-A nrPDB Length = 310 Score = 207 bits (526), Expect = 8e-54, Method: Composition-based stats. Identities = 68/258 (26%), Positives = 117/258 (45%), Gaps = 19/258 (7%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR-RTYRELRLLKHLKHE 81 + + +G G + V A VA+KK+ AR +E+ LLK L H Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKC-----QALSDEHVQFLVYQLL 135 NVI F + +E+ +V L DL+ ++K + + + V QL Sbjct: 93 NVIKYYASFI------EDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLC 146 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT---GYVATRWYRAPE 192 L+++HS ++HRD+KP+NV + +++ D GL R + T V T +Y +PE Sbjct: 147 SALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPE 206 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 + + YN DIWS+GC++ E+ ++ F G D ++ ++ P + + S Sbjct: 207 RI-HENGYNFKSDIWSLGCLLYEMAALQSPFYG-DKMNLYSLCKKIEQCDYPPLPSDHYS 264 Query: 253 EHARTYIQ-SLPPMPQKD 269 E R + + P P+K Sbjct: 265 EELRQLVNMCINPDPEKR 282 >4OTD-A nrPDB Length = 341 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 70/354 (19%), Positives = 131/354 (37%), Gaps = 52/354 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHL-- 78 + + L +G G +G V + + A+K L + + E R+L + Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 71 Query: 79 -KHENVIGLLDVFTPATSIEDFSEVYLVTTL-MGADLNNIVKCQALSDEHVQFLVYQLLR 136 H ++ L F V V G DL + S+ F ++ Sbjct: 72 AGHPFLVNLFGCFQTPE------HVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVL 125 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ---ADEEMTGYVATRWYRAPEI 193 GL+++H I++RDLK N+ ++ + ++I DFGL ++ + + + T + APE+ Sbjct: 126 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 185 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSE 253 + + Y + VD W +G ++ E+L G++ FPG D + I+ Sbjct: 186 LTD-TSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN---------------- 228 Query: 254 HARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEALAHAYF 308 D R + AI ++ R+L + ++R+ A + +F Sbjct: 229 ---------------DEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF 273 Query: 309 SQYHDPEDEPEAEPYDESVEAKERT-LEEWKELTYQEVLSFKPPEPPKPPGSLE 361 P RT + + E E + PP +P + E Sbjct: 274 RTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAE 327 >3A4O-X nrPDB Length = 286 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 72/267 (26%), Positives = 118/267 (44%), Gaps = 25/267 (9%) Query: 14 NKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYREL 72 +K WE+P+ ++ ++ +G+G +G V Y KVAVK L S + E Sbjct: 4 DKDAWEIPRESIKLVKRLGAGQFGEVWMGY-YNNSTKVAVKTLKPGTMS---VQAFLEEA 59 Query: 73 RLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKC---QALSDEHVQ 128 L+K L+H+ ++ L V T I Y++T M L + +K + + Sbjct: 60 NLMKTLQHDKLVRLYAVVTREEPI------YIITEYMAKGSLLDFLKSDEGGKVLLPKLI 113 Query: 129 FLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRW 187 Q+ G+ YI IHRDL+ +NV V+E +I DFGLAR D E T ++ Sbjct: 114 DFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKF 173 Query: 188 ---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTP- 242 + APE + N+ + D+WS G ++ E++ GK +PG D + + + P Sbjct: 174 PIKWTAPEAI-NFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPR 232 Query: 243 ---SPEVLAKISSEHARTYIQSLPPMP 266 P+ L I + + P Sbjct: 233 VENCPDELYDIMKMCWKEKAEERPTFD 259 >4CRS-A nrPDB Length = 341 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 70/346 (20%), Positives = 133/346 (38%), Gaps = 52/346 (15%) Query: 32 SGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRL---LKHLKHENVIGLL 87 G +G V A + A+K L + + E R+ + ++H ++ L Sbjct: 22 RGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLF 81 Query: 88 DVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGII 147 F + +++ G DL + S+ F ++ GL+Y+H I+ Sbjct: 82 ACFQTKEHV-----CFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIV 136 Query: 148 HRDLKPSNVAVNEDCELRILDFGLARQ---ADEEMTGYVATRWYRAPEIMLNWMHYNQTV 204 +RDLK N+ ++ + ++I DFGL ++ + + + T + APE++ Y + V Sbjct: 137 YRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL-TETSYTRAV 195 Query: 205 DIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPP 264 D W +G ++ E+L G++ FPG D + I+ Sbjct: 196 DWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVN--------------------------- 228 Query: 265 MPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEALAHAYFS--QYHDPEDE 317 D R + AI ++ R+L + ++R+ A + H +F + D+ Sbjct: 229 ----DEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDK 284 Query: 318 PEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSLEIE 363 P+ ++ +E E T E PP P+ E E Sbjct: 285 KVKPPFIPTIRGREDVSNFDDEFT-SEAPILTPPREPRILSEEEQE 329 >1K9A-A nrPDB Length = 450 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 69/306 (22%), Positives = 126/306 (41%), Gaps = 53/306 (17%) Query: 10 RQELNKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT 68 + E ++ W + + L+ L+ +G G +G V D R KVAVK + A+ Sbjct: 180 QDEFYRSGWALNMKELKLLQTIGKGEFGDVMLG-DYR-GNKVAVKCIKNDAT----AQAF 233 Query: 69 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQA---LSD 124 E ++ L+H N++ LL V +E+ +Y+VT M L + ++ + L Sbjct: 234 LAEASVMTQLRHSNLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGG 288 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM-TGYV 183 + + + ++Y+ +HRDL NV V+ED ++ DFGL ++A TG + Sbjct: 289 DCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL 348 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTP 242 +W APE + ++ D+WS G ++ E+ G+ +P D + R+ + Sbjct: 349 PVKW-TAPEAL-REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMD 406 Query: 243 SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEA 302 +P+ G P D++ LD+ R + + Sbjct: 407 APD------------------------------GCPPAVYDVMKNCWHLDAATRPTFLQL 436 Query: 303 ---LAH 305 L H Sbjct: 437 REQLEH 442 >4UY9-A nrPDB Length = 323 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 70/260 (26%), Positives = 111/260 (42%), Gaps = 29/260 (11%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA--RRTYRELRLLKHLKHE 81 L +G G +G V A+ +VAVK I +E +L LKH Sbjct: 11 LTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHP 68 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLKY 140 N+I L V + + LV G LN ++ + + + + Q+ RG+ Y Sbjct: 69 NIIALRGVCLKEPN------LCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNY 122 Query: 141 IHSAG---IIHRDLKPSNVAVNE--------DCELRILDFGLARQADEEMT-GYVATRWY 188 +H IIHRDLK SN+ + + + L+I DFGLAR+ T + Sbjct: 123 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAW 182 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD-----YIDQLKRIMEVVGTPS 243 APE++ M +++ D+WS G ++ ELL G+ F G D Y + ++ + + Sbjct: 183 MAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTC 241 Query: 244 PEVLAKISSEHARTYIQSLP 263 PE AK+ + S P Sbjct: 242 PEPFAKLMEDCWNPDPHSRP 261 >2XNP-A nrPDB Length = 279 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 73/299 (24%), Positives = 123/299 (41%), Gaps = 49/299 (16%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + + L +G+G+YG + + K+L + + E+ LL+ LKH Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV-----KCQALSDEHVQFLVYQLL 135 N++ D T+ + +Y+V G DL +++ + Q L +E V ++ QL Sbjct: 66 NIVRYYDRIIDRTN----TTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLT 121 Query: 136 RGLKYIHS-----AGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM---TGYVATRW 187 LK H ++HRDLKP+NV ++ +++ DFGLAR + + +V T + Sbjct: 122 LALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPY 181 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 247 Y +PE +N M YN+ DIWS+GC++ EL F + +I E Sbjct: 182 YMSPE-QMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREG--------- 231 Query: 248 AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHA 306 I + +++ RML L R S E L + Sbjct: 232 ---------------------KFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENP 269 >4EBW-A nrPDB Length = 304 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 65/308 (21%), Positives = 115/308 (37%), Gaps = 56/308 (18%) Query: 6 AGFYRQELNKTV---WEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQK---VAVKKLSRP 58 Y Q + +E+ +R++ R +G G +G V VA+K + Sbjct: 18 ENLYFQGAMGSSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTC-KN 76 Query: 59 FQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIV 117 S + +E ++ H +++ L+ V T + V+++ L +L + + Sbjct: 77 CTSDSVREKFLQEALTMRQFDHPHIVKLIGVITE-------NPVWIIMELCTLGELRSFL 129 Query: 118 KCQALSDEHVQF--LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA 175 + + S + YQL L Y+ S +HRD+ NV V+ + +++ DFGL+R Sbjct: 130 QVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM 189 Query: 176 DEEMTGYVATRW-----YRAPEIMLNWMHYNQTVDIWSVGCIMAE-LLQGKALFPGSDYI 229 E+ T Y A++ + APE + N+ + D+W G M E L+ G F G Sbjct: 190 -EDSTYYKASKGKLPIKWMAPESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNN 247 Query: 230 DQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRML 289 D + RI P P P L+ + Sbjct: 248 DVIGRIENGERLPMP------------------------------PNCPPTLYSLMTKCW 277 Query: 290 VLDSDQRV 297 D +R Sbjct: 278 AYDPSRRP 285 >5VO2-A nrPDB Length = 300 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 74/332 (22%), Positives = 135/332 (40%), Gaps = 53/332 (15%) Query: 14 NKTVWEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYREL 72 ++ +WEVP + + L+ VGSGA G+V ++VAVKK+ ++ + Sbjct: 3 SEDLWEVPFEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD---------I 51 Query: 73 RLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKC-QALSDEHVQFL 130 + L+ LKH N+I V T A ++ L +++ + ++ + Sbjct: 52 KHLRKLKHPNIITFKGVCTQAPC------YCILMEFCAQGQLYEVLRAGRPVTPSLLVDW 105 Query: 131 VYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT--GYVATRWY 188 + G+ Y+H IIHRDLK N+ + D ++I DFG +++ ++ T + T + Sbjct: 106 SMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAW 165 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLA 248 APE++ N ++ VDIWS G ++ ELL G+ + D I+ VG+ S + Sbjct: 166 MAPEVIRN-EPVSEKVDIWSFGVVLWELLTGEIPYKDVDS----SAIIWGVGSNSLHL-- 218 Query: 249 KISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 + LL + R S + L H Sbjct: 219 -----------------------PVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDI 255 Query: 309 SQYHDPEDEPEAEPYDESVEAKERTLEEWKEL 340 + D P+ + E +E ++++ Sbjct: 256 AS-ADVLSTPQETYFKSQAEWREEVKLHFEKI 286 >5O2B-A nrPDB Length = 285 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 64/288 (22%), Positives = 124/288 (43%), Gaps = 38/288 (13%) Query: 29 PVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 +G GA+ +V D +VA +L + +R E +LK L+H N++ D Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 82 Query: 89 VFTPATSIEDFSEVYLVTTLM-GADLNNIVKC-QALSDEHVQFLVYQLLRGLKYIHSAG- 145 + + ++ + LVT LM L +K + + + ++ Q+L+GL+++H+ Sbjct: 83 SWE--SILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 140 Query: 146 -IIHRDLKPSNVAVN-EDCELRILDFGLARQA-DEEMTGYVATRWYRAPEIMLNWMHYNQ 202 IIHRDLK N+ + ++I D GLA + T + APE+ HY++ Sbjct: 141 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMY--EEHYDE 198 Query: 203 TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSL 262 +VD+++ G M E+ + + Q+ R +V P K++ Sbjct: 199 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYR--KVTSGIKPASFNKVT----------- 245 Query: 263 PPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 +P +++ + + +R+S + L HA+F++ Sbjct: 246 ---------------DPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 >1BYG-A nrPDB Length = 278 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 72/315 (22%), Positives = 129/315 (40%), Gaps = 55/315 (17%) Query: 1 MSGPRAGFYRQELNKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPF 59 M G A + E ++ W + + L+ L+ +G G +G V D R KVAVK + Sbjct: 1 MGGSVAA--QDEFYRSGWALNMKELKLLQTIGKGEFGDVMLG-DYR-GNKVAVKCIKNDA 56 Query: 60 QSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVK 118 A+ E ++ L+H N++ LL V +E+ +Y+VT M L + ++ Sbjct: 57 T----AQAFLAEASVMTQLRHSNLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLR 107 Query: 119 CQA---LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA 175 + L + + + ++Y+ +HRDL NV V+ED ++ DFGL ++A Sbjct: 108 SRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA 167 Query: 176 DEEM-TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLK 233 TG + +W APE + ++ D+WS G ++ E+ G+ +P D + Sbjct: 168 SSTQDTGKLPVKW-TAPEAL-REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVP 225 Query: 234 RIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDS 293 R+ + +P+ G P +++ LD+ Sbjct: 226 RVEKGYKMDAPD------------------------------GCPPAVYEVMKNCWHLDA 255 Query: 294 DQRVSAAEA---LAH 305 R S + L H Sbjct: 256 AMRPSFLQLREQLEH 270 >2OGV-A nrPDB Length = 317 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 115/297 (38%), Gaps = 33/297 (11%) Query: 10 RQELNKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQ-----KVAVKKLSRPFQSLI 63 Q WE P+ LQ + +G+GA+G V A L + KVAVK L + Sbjct: 25 TQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHAD 83 Query: 64 HARRTYRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC--- 119 EL+++ HL +HEN++ LL T + + + DL N ++ Sbjct: 84 EKEALMSELKIMSHLGQHENIVNLLGACTHGGPV-----LVITEYCCYGDLLNFLRRKAE 138 Query: 120 --------QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGL 171 + L + Q+ +G+ ++ S IHRD+ NV + +I DFGL Sbjct: 139 ADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGL 198 Query: 172 ARQADEEMTGYV------ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFP 224 AR + V +W APE + + + Y D+WS G ++ E+ G +P Sbjct: 199 ARDIMNDSNYIVKGNARLPVKW-MAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYP 256 Query: 225 GSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLA 281 G + ++++ + A + +L P + I A Sbjct: 257 GILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQA 313 >3DTC-A nrPDB Length = 271 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 69/260 (26%), Positives = 110/260 (42%), Gaps = 29/260 (11%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA--RRTYRELRLLKHLKHE 81 L +G G +G V A+ +VAVK I +E +L LKH Sbjct: 9 LTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHP 66 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGLKY 140 N+I L V + + LV G LN ++ + + + + Q+ RG+ Y Sbjct: 67 NIIALRGVCLKEPN------LCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNY 120 Query: 141 IHSAG---IIHRDLKPSNVAVNE--------DCELRILDFGLARQADEEMT-GYVATRWY 188 +H IIHRDLK SN+ + + + L+I DFGLAR+ + Sbjct: 121 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYAW 180 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD-----YIDQLKRIMEVVGTPS 243 APE++ M +++ D+WS G ++ ELL G+ F G D Y + ++ + + Sbjct: 181 MAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTC 239 Query: 244 PEVLAKISSEHARTYIQSLP 263 PE AK+ + S P Sbjct: 240 PEPFAKLMEDCWNPDPHSRP 259 >4XCU-A nrPDB Length = 300 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 73/314 (23%), Positives = 117/314 (37%), Gaps = 62/314 (19%) Query: 15 KTVWEVPQ-RLQGLRPVGSGAYGSVCSAYDARLR-------QKVAVKKLSRPFQSLIHAR 66 +WE P+ RL +P+G G +G V A + VAVK L + S Sbjct: 9 DPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKML-KDNASDKDLA 67 Query: 67 RTYRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA---- 121 E+ ++K + +H+N+I LL V T + +V +L ++ + Sbjct: 68 DLVSEMEVMKLIGRHKNIINLLGVCTQEGPL-----YVIVECAAKGNLREFLRARRPPGS 122 Query: 122 ----LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE 177 LS + YQ+ RG++Y+ S IHRDL NV V ED ++I DFGLAR Sbjct: 123 SEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHH 182 Query: 178 ------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYID 230 G + +W APE + + + Y D+WS G ++ E+ G + +PG + Sbjct: 183 IDYYKKTSNGRLPVKW-MAPEALFDRV-YTHQSDVWSFGILLWEIFTLGGSPYPGIPVEE 240 Query: 231 QLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLV 290 + E P P L+ Sbjct: 241 LFSLLREGHRMDRP------------------------------PHCPPELYGLMRECWH 270 Query: 291 LDSDQRVSAAEALA 304 QR + + + Sbjct: 271 AAPSQRPTFKQLVE 284 >4E93-A nrPDB Length = 377 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 68/303 (22%), Positives = 116/303 (38%), Gaps = 51/303 (16%) Query: 15 KTVWEV-PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELR 73 K W + + L +G G +G V S VAVK + A+ +E R Sbjct: 106 KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK-FLQEAR 164 Query: 74 LLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQ--ALSDEHVQFL 130 +LK H N++ L+ V T I Y+V L+ G D ++ + L + + + Sbjct: 165 ILKQYSHPNIVRLIGVCTQKQPI------YIVMELVQGGDFLTFLRTEGARLRVKTLLQM 218 Query: 131 VYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW--- 187 V G++Y+ S IHRDL N V E L+I DFG++R+ + + Sbjct: 219 VGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVP 278 Query: 188 --YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSP 244 + APE + N+ Y+ D+WS G ++ E G + +P + + + P P Sbjct: 279 VKWTAPEAL-NYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCP 337 Query: 245 EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV---SAAE 301 E+ ++FR L+ + + QR + + Sbjct: 338 ELCPD----------------------AVFR--------LMEQCWAYEPGQRPSFSTIYQ 367 Query: 302 ALA 304 L Sbjct: 368 ELQ 370 >4TNB-A nrPDB Length = 590 Score = 203 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 76/334 (22%), Positives = 133/334 (39%), Gaps = 54/334 (16%) Query: 10 RQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKL-SRPFQSLIHARRT 68 RQ + K + ++ R +G G +G VC+ + A K+L + + Sbjct: 178 RQPVTKNTF---RQY---RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA 231 Query: 69 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKC---QALSD 124 E ++L+ + + V+ L A + E + LV T+M G DL + + Sbjct: 232 LNEKQILEKVNSQFVVNL------AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEE 285 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGY 182 E F ++L GL+ +H ++RDLKP N+ +++ +RI D GLA + E + G Sbjct: 286 ERALFYAAEILCGLEDLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR 345 Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTP 242 V T Y APE++ N Y + D W +GC++ E+++G++ F G Sbjct: 346 VGTVGYMAPEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKE-------------- 390 Query: 243 SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS---- 298 K+ E + + + A + +L D+ QR+ Sbjct: 391 ------KVKREEVDRRVLETEEV-------YSHKFSEEAKSICKMLLTKDAKQRLGCQEE 437 Query: 299 -AAEALAHAYFSQYHDPEDEP--EAEPYDESVEA 329 AAE H +F + E P+ A Sbjct: 438 EAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRA 471 >6DBM-A nrPDB Length = 318 Score = 203 bits (518), Expect = 7e-53, Method: Composition-based stats. Identities = 67/312 (21%), Positives = 118/312 (37%), Gaps = 35/312 (11%) Query: 3 GPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCS-AYDAR---LRQKVAVKKLSRP 58 G ++ + TV+ + L+ +R +G G +G V YD + VAVK L Sbjct: 13 GALEVLFQGPGDPTVFH-KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKAD 71 Query: 59 FQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIV 117 H +E+ +L+ L HE++I A + + LV + L + + Sbjct: 72 A-GPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDAGAAS----LQLVMEYVPLGSLRDYL 126 Query: 118 KCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE 177 ++ + Q+ G+ Y+HS IHRDL NV ++ D ++I DFGLA+ E Sbjct: 127 PRHSIGLAQLLLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPE 186 Query: 178 EMTGYV-------ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID 230 Y WY APE + + Y D+WS G + ELL Sbjct: 187 GHEYYRVREDGDSPVFWY-APECLKEYKFY-YASDVWSFGVTLYELLT-----HCDSSQS 239 Query: 231 QLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLV 290 + +E++G +++ ++ +P+ D L+ Sbjct: 240 PPTKFLELIGI----AQGQMTVLRLTELLERGERLPRPD------KCPAEVYHLMKNCWE 289 Query: 291 LDSDQRVSAAEA 302 ++ R + Sbjct: 290 TEASFRPTFENL 301 >3BEA-A nrPDB Length = 333 Score = 203 bits (517), Expect = 8e-53, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 116/301 (38%), Gaps = 37/301 (12%) Query: 10 RQELNKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQ-----KVAVKKLSRPFQSLI 63 Q WE P+ LQ + +G+GA+G V A L + KVAVK L + Sbjct: 33 TQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHAD 91 Query: 64 HARRTYRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ-- 120 EL+++ HL +HEN++ LL T + + + DL N ++ + Sbjct: 92 EKEALMSELKIMSHLGQHENIVNLLGACTHGGPV-----LVITEYCCYGDLLNFLRRKSR 146 Query: 121 -------------ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRIL 167 LS + Q+ +G+ ++ S IHRD+ NV + +I Sbjct: 147 VLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIG 206 Query: 168 DFGLARQADEEMTGYV------ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GK 220 DFGLAR + V +W APE + + + Y D+WS G ++ E+ G Sbjct: 207 DFGLARDIMNDSNYIVKGNARLPVKW-MAPESIFDCV-YTVQSDVWSYGILLWEIFSLGL 264 Query: 221 ALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPL 280 +PG + ++++ + A + +L P + I Sbjct: 265 NPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQ 324 Query: 281 A 281 A Sbjct: 325 A 325 >5H2U-A nrPDB Length = 267 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 67/291 (23%), Positives = 120/291 (41%), Gaps = 48/291 (16%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + R +GSG +G V R +VA+K +SR +L+H + E++ +K L+H+ Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWKD-RVQVAIKVISRD--NLLHQQMLQSEIQAMKKLRHK 62 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVK---CQALSDEHVQFLVYQLLRG 137 +++ L V + VY++T LM L +++ + L + + +Q+ G Sbjct: 63 HILALYAVVSVGDP------VYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEG 116 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVATRW-YRAPEIM 194 + Y+ S IHRDL N+ V E+ ++ DFGLAR E+ ++ + + APE + Sbjct: 117 MCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEAL 176 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSE 253 + HY+ D+WS G ++ E+ G+ +PG + R+ P P Sbjct: 177 -SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCP--------- 226 Query: 254 HARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 P L+ D +QR + Sbjct: 227 ---------------------LECPPSVHKLMLTCWCRDPEQRPTFKALRE 256 >4UYA-A nrPDB Length = 340 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 72/279 (25%), Positives = 116/279 (41%), Gaps = 32/279 (11%) Query: 5 RAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSL-- 62 +++ +E RL+ +G+G +G V A Q+VAVK + + Sbjct: 12 ENLYFQGSPVHVAFE---RLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAA 66 Query: 63 IHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA 121 A RE RL L+H N+I L V + LV G LN + + Sbjct: 67 AAAESVRREARLFAMLRHPNIIELRGVCLQQP------HLCLVLEFARGGALNRALAGRR 120 Query: 122 LSDEHVQFLVYQLLRGLKYIHSAG---IIHRDLKPSNVAVNE--------DCELRILDFG 170 + + Q+ RG+ Y+H I+HRDLK SN+ + E + L+I DFG Sbjct: 121 IPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFG 180 Query: 171 LARQADEEMT-GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD-- 227 LAR+ + APE++ +++ DIWS G ++ ELL G+ + G D Sbjct: 181 LAREWHRTTKMATAGAYAWMAPEVI-KSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGL 239 Query: 228 ---YIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLP 263 Y + ++ + + PE AK+ E + P Sbjct: 240 AVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRP 278 >5O2C-A nrPDB Length = 380 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 64/288 (22%), Positives = 124/288 (43%), Gaps = 38/288 (13%) Query: 29 PVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 +G GA+ +V D +VA +L + +R E +LK L+H N++ D Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 91 Query: 89 VFTPATSIEDFSEVYLVTTLM-GADLNNIVKC-QALSDEHVQFLVYQLLRGLKYIHSAG- 145 + + ++ + LVT LM L +K + + + ++ Q+L+GL+++H+ Sbjct: 92 SWE--SILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 149 Query: 146 -IIHRDLKPSNVAVN-EDCELRILDFGLARQA-DEEMTGYVATRWYRAPEIMLNWMHYNQ 202 IIHRDLK N+ + ++I D GLA + T + APE+ HY++ Sbjct: 150 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMY--EEHYDE 207 Query: 203 TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSL 262 +VD+++ G M E+ + + Q+ R +V P K++ Sbjct: 208 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYR--KVTSGIKPASFNKVT----------- 254 Query: 263 PPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 +P +++ + + +R+S + L HA+F++ Sbjct: 255 ---------------DPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 287 >4EQM-A nrPDB Length = 294 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 69/273 (25%), Positives = 129/273 (47%), Gaps = 19/273 (6%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA-RRTYRELRLLKHL 78 + +R + + +G G +V A D L KVA+K + P + +R RE+ L Sbjct: 9 INERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQL 68 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA-LSDEHVQFLVYQLLR 136 H+N++ ++DV E+ YLV + G L+ ++ LS + Q+L Sbjct: 69 SHQNIVSMIDV------DEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILD 122 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE----EMTGYVATRWYRAPE 192 G+K+ H I+HRD+KP N+ ++ + L+I DFG+A+ E + + T Y +PE Sbjct: 123 GIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPE 182 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID-QLKRIMEVVGTPSPEVLAKIS 251 ++ DI+S+G ++ E+L G+ F G + +K I + V + +V I Sbjct: 183 QAKGEAT-DECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDIP 241 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDL 284 + +++ +KD ++ ++ + DL Sbjct: 242 QSLSNVILRA----TEKDKANRYKTIQEMKDDL 270 >3G0E-A nrPDB Length = 336 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 75/328 (22%), Positives = 121/328 (36%), Gaps = 70/328 (21%) Query: 10 RQELNKTVWEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQ-----KVAVKKLSRPFQSLI 63 Q WE P+ RL + +G+GA+G V A L + VAVK L +P L Sbjct: 33 TQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKML-KPSAHLT 91 Query: 64 HARRTYRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA- 121 EL++L +L H N++ LL T + + DL N ++ + Sbjct: 92 EREALMSELKVLSYLGNHMNIVNLLGACTIGGP-----TLVITEYCCYGDLLNFLRRKRD 146 Query: 122 ------------------LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE 163 L E + YQ+ +G+ ++ S IHRDL N+ + Sbjct: 147 SFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRI 206 Query: 164 LRILDFGLARQADEEMTGYV------ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 +I DFGLAR + V +W APE + N + Y D+WS G + EL Sbjct: 207 TKICDFGLARDIKNDSNYVVKGNARLPVKW-MAPESIFNCV-YTFESDVWSYGIFLWELF 264 Query: 218 Q-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRG 276 G + +PG + ++++ E +S EHA Sbjct: 265 SLGSSPYPGMPVDSKFYKMIK-------EGFRMLSPEHAPA------------------- 298 Query: 277 ANPLAIDLLGRMLVLDSDQRVSAAEALA 304 D++ D +R + + + Sbjct: 299 ---EMYDIMKTCWDADPLKRPTFKQIVQ 323 >6GVJ-A nrPDB Length = 429 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 75/315 (23%), Positives = 126/315 (40%), Gaps = 54/315 (17%) Query: 21 PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK- 79 + L+ +GSG V + + +Q A+K ++ E+ L L+ Sbjct: 143 GRIYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 201 Query: 80 -HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-LSDEHVQFLVYQLLRG 137 + +I L D +Y+V DLN+ +K + + + +L Sbjct: 202 HSDKIIRLYDYEIT------DQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEA 255 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY-----VATRWYRAPE 192 + IH GI+H DLKP+N + D L+++DFG+A Q + T V T Y PE Sbjct: 256 VHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPE 314 Query: 193 IMLNWMHYNQ----------TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTP 242 + + + D+WS+GCI+ + GK F I+Q+ ++ ++ P Sbjct: 315 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAII-DP 371 Query: 243 SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEA 302 + E+ P +P+KDL D+L L D QR+S E Sbjct: 372 NHEI--------------EFPDIPEKDLQ-----------DVLKCCLKRDPKQRISIPEL 406 Query: 303 LAHAYFSQYHDPEDE 317 LAH Y P ++ Sbjct: 407 LAHPYVQIQTHPVNQ 421 >5KKR-C nrPDB Length = 395 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 66/305 (21%), Positives = 124/305 (40%), Gaps = 23/305 (7%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + + +G+G G V +A K + + I + REL++L Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ-IIRELQVLHECNSP 126 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-QALSDEHVQFLVYQLLRGLKY 140 ++G F I + + G L+ ++K + ++ + + +++GL Y Sbjct: 127 YIVGFYGAFYSDGEISIC-----MEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 181 Query: 141 I-HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ-ADEEMTGYVATRWYRAPEIMLNWM 198 + I+HRD+KPSN+ VN E+++ DFG++ Q D +V TR Y +PE + Sbjct: 182 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-T 240 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH---A 255 HY+ DIWS+G + E+ G+ P D + V + E + + + Sbjct: 241 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 300 Query: 256 RTYIQSLPPMPQKDLSSIFRGANP----------LAIDLLGRMLVLDSDQRVSAAEALAH 305 + S PPM +L P D + + L+ + +R + + H Sbjct: 301 SYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVH 360 Query: 306 AYFSQ 310 A+ + Sbjct: 361 AFIKR 365 >3TT0-A nrPDB Length = 382 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 74/282 (26%), Positives = 114/282 (40%), Gaps = 51/282 (18%) Query: 6 AGFYRQEL----------NKTVWEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQ------ 48 Y Q + WE+P+ RL +P+G GA+G V A L + Sbjct: 42 ENLYFQGMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRV 101 Query: 49 -KVAVKKLSRPFQSLIHARRTYRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVT 106 KVAVK L E+ ++K + KH+N+I LL T + +V Sbjct: 102 TKVAVKMLKSDATE-KDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVE 155 Query: 107 TLMGADLNNIVKCQA-----------------LSDEHVQFLVYQLLRGLKYIHSAGIIHR 149 +L ++ + LS + + YQ+ RG++Y+ S IHR Sbjct: 156 YASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHR 215 Query: 150 DLKPSNVAVNEDCELRILDFGLARQADE------EMTGYVATRWYRAPEIMLNWMHYNQT 203 DL NV V ED ++I DFGLAR G + +W APE + + + Y Sbjct: 216 DLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKW-MAPEALFDRI-YTHQ 273 Query: 204 VDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSP 244 D+WS G ++ E+ G + +PG + K + E P Sbjct: 274 SDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKP 315 >4KIK-B nrPDB Length = 677 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 71/296 (23%), Positives = 127/296 (42%), Gaps = 33/296 (11%) Query: 17 VWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLK 76 WE+ +R +G+G +G+V ++ +++A+K+ + S + R E+++++ Sbjct: 20 AWEMKER------LGTGGFGNVIRWHNQETGEQIAIKQCRQEL-SPRNRERWCLEIQIMR 72 Query: 77 HLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVK----CQALSDEHVQFLV 131 L H NV+ DV ++ L G DL + C L + + L+ Sbjct: 73 RLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLL 132 Query: 132 YQLLRGLKYIHSAGIIHRDLKPSNVAV---NEDCELRILDFGLARQADEE--MTGYVATR 186 + L+Y+H IIHRDLKP N+ + + +I+D G A++ D+ T +V T Sbjct: 133 SDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTL 192 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALF----PGSDYIDQLKRIMEVVGTP 242 Y APE +L Y TVD WS G + E + G F + ++++ EV Sbjct: 193 QYLAPE-LLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVV 251 Query: 243 SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS 298 S ++ + + Y +L + + L L ML+ QR + Sbjct: 252 SEDLNGTVKFSSSLPYPNNLNSVLAERLEKW-----------LQLMLMWHPRQRGT 296 >3KRL-A nrPDB Length = 335 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 69/303 (22%), Positives = 116/303 (38%), Gaps = 39/303 (12%) Query: 10 RQELNKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQ-----KVAVKKLSRPFQSLI 63 Q WE P+ LQ + +G+GA+G V A L + KVAVK L + Sbjct: 33 TQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHAD 91 Query: 64 HARRTYRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA- 121 EL+++ HL +HEN++ LL T + + + DL N ++ + Sbjct: 92 EKEALMSELKIMSHLGQHENIVNLLGACTHGGPV-----LVITEYCCYGDLLNFLRRKRP 146 Query: 122 ----------------LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELR 165 LS + Q+ +G+ ++ S IHRD+ NV + + Sbjct: 147 PGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAK 206 Query: 166 ILDFGLARQADEEMTGYV------ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ- 218 I DFGLAR + V +W APE + + + Y D+WS G ++ E+ Sbjct: 207 IGDFGLARDIMNDSNYIVKGNARLPVKW-MAPESIFDCV-YTVQSDVWSYGILLWEIFSL 264 Query: 219 GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGAN 278 G +PG + ++++ + A + +L P + I Sbjct: 265 GLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQ 324 Query: 279 PLA 281 A Sbjct: 325 EQA 327 >3EQC-A nrPDB Length = 360 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 66/305 (21%), Positives = 124/305 (40%), Gaps = 23/305 (7%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + + +G+G G V +A K + + I + REL++L Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ-IIRELQVLHECNSP 91 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-QALSDEHVQFLVYQLLRGLKY 140 ++G F I + + G L+ ++K + ++ + + +++GL Y Sbjct: 92 YIVGFYGAFYSDGEISIC-----MEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 146 Query: 141 I-HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ-ADEEMTGYVATRWYRAPEIMLNWM 198 + I+HRD+KPSN+ VN E+++ DFG++ Q D +V TR Y +PE + Sbjct: 147 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-T 205 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA--- 255 HY+ DIWS+G + E+ G+ P D + V + E + + Sbjct: 206 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLN 265 Query: 256 RTYIQSLPPMPQKDLSSIFRGANP----------LAIDLLGRMLVLDSDQRVSAAEALAH 305 + + S PPM +L P D + + L+ + +R + + H Sbjct: 266 KFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVH 325 Query: 306 AYFSQ 310 A+ + Sbjct: 326 AFIKR 330 >1ZXE-A nrPDB Length = 303 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 73/327 (22%), Positives = 132/327 (40%), Gaps = 61/327 (18%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + + +G GA+G V A +A + A+KK+ + L E+ LL L H+ Sbjct: 6 SDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLS---TILSEVMLLASLNHQ 62 Query: 82 NVIGLL-------DVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSD--EHVQFLV 131 V+ + P T+++ S +++ L +++ + L+ + L Sbjct: 63 YVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLF 122 Query: 132 YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD--------------- 176 Q+L L YIHS GIIHR+LKP N+ ++E ++I DFGLA+ Sbjct: 123 RQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPG 182 Query: 177 --EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFP-GSDYIDQLK 233 + +T + T Y A E++ HYN+ +D++S+G I E++ F G + ++ LK Sbjct: 183 SSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTGMERVNILK 239 Query: 234 RIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDS 293 ++ V P+ + ++ ++ D Sbjct: 240 KLRSVSIEFPPDFDDNKMKVEKK---------------------------IIRLLIDHDP 272 Query: 294 DQRVSAAEALAHAYFSQYHDPEDEPEA 320 ++R A L + H E EA Sbjct: 273 NKRPGARTLLNSGWLPVKHQDEVIKEA 299 >4PWN-A nrPDB Length = 274 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 64/289 (22%), Positives = 121/289 (41%), Gaps = 39/289 (13%) Query: 29 PVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 +G G++ +V D +VA +L + +R E +LK L+H N++ D Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYD 76 Query: 89 VFTPATSIEDFSEVYLVTTLM-GADLNNIVKC-QALSDEHVQFLVYQLLRGLKYIHSAG- 145 + ++++ + LVT LM L +K + + + ++ Q+L+GL+++H+ Sbjct: 77 SWE--STVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTP 134 Query: 146 -IIHRDLKPSNVAVN-EDCELRILDFGLARQAD--EEMTGYVATRWYRAPEIMLNWMHYN 201 IIHRDLK N+ + ++I D GLA + T + APE+ Y+ Sbjct: 135 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMY--EEKYD 192 Query: 202 QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQS 261 ++VD+++ G M E+ + + Q+ R V P K+ Sbjct: 193 ESVDVYAFGMCMLEMATSEYPYSECQNAAQIYR--RVTSGVKPASFDKV----------- 239 Query: 262 LPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 A P +++ + + D+R S + L HA+F + Sbjct: 240 ---------------AIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >1TKI-A nrPDB Length = 321 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 64/299 (21%), Positives = 123/299 (41%), Gaps = 44/299 (14%) Query: 19 EVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL 78 E+ ++ +G G +G V + ++ K + + ++ E+ +L Sbjct: 2 ELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKK---EISILNIA 58 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQAL--SDEHVQFLVYQLL 135 +H N++ L + F E E+ ++ + G D+ + A ++ + V+Q+ Sbjct: 59 RHRNILHLHESF------ESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVC 112 Query: 136 RGLKYIHSAGIIHRDLKPSNVA--VNEDCELRILDFGLARQA--DEEMTGYVATRWYRAP 191 L+++HS I H D++P N+ ++I++FG ARQ + Y AP Sbjct: 113 EALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAP 172 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 E+ + + + D+WS+G ++ LL G F ++ IM T E +IS Sbjct: 173 EVHQHDV-VSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEIS 231 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 E A+D + R+LV + R++A+EAL H + Q Sbjct: 232 IE---------------------------AMDFVDRLLVKERKSRMTASEALQHPWLKQ 263 >2J0K-A nrPDB Length = 656 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 63/301 (20%), Positives = 110/301 (36%), Gaps = 52/301 (17%) Query: 9 YRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQK---VAVKKLSRPFQSLIHA 65 Y + +R++ R +G G +G V VA+K + S Sbjct: 377 YTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTC-KNCTSDSVR 435 Query: 66 RRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSD 124 + +E ++ H +++ L+ V T + V+++ L +L + ++ + S Sbjct: 436 EKFLQEALTMRQFDHPHIVKLIGVITE-------NPVWIIMELCTLGELRSFLQVRKFSL 488 Query: 125 EHVQF--LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY 182 + YQL L Y+ S +HRD+ NV V+ +++ DFGL+R E+ T Y Sbjct: 489 DLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYM-EDSTYY 547 Query: 183 VATRW-----YRAPEIMLNWMHYNQTVDIWSVGCIMAE-LLQGKALFPGSDYIDQLKRIM 236 A++ + APE + N+ + D+W G M E L+ G F G D + RI Sbjct: 548 KASKGKLPIKWMAPESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIE 606 Query: 237 EVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQR 296 P P P L+ + D +R Sbjct: 607 NGERLPMP------------------------------PNCPPTLYSLMTKCWAYDPSRR 636 Query: 297 V 297 Sbjct: 637 P 637 >5A46-A nrPDB Length = 386 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 83/375 (22%), Positives = 132/375 (35%), Gaps = 78/375 (20%) Query: 18 WEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQ-------KVAVKKLSRPFQSLIHARRTY 69 WE+P+ RL +P+G G +G V A L + KVAVK L Sbjct: 35 WELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATE-KDLSDLI 93 Query: 70 RELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA------- 121 E+ ++K + KH+N+I LL T + +V +L ++ + Sbjct: 94 SEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLQARRPPGLEYC 148 Query: 122 ----------LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGL 171 LS + + YQ+ RG++Y+ S IHRDL NV V ED ++I DFGL Sbjct: 149 YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGL 208 Query: 172 ARQADE------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFP 224 AR G + +W APE + + + Y D+WS G ++ E+ G + +P Sbjct: 209 ARDIHHIDYYKKTTNGRLPVKW-MAPEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYP 266 Query: 225 GSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDL 284 G + K + E P + Sbjct: 267 GVPVEELFKLLKEGHRMDKP------------------------------SNCTNELYMM 296 Query: 285 LGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPE----AEPYDESVEAKERTLEEWKEL 340 + QR + + + + E + P D+ + T Sbjct: 297 MRDCWHAVPSQRPTFKQLVED--LDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSS 354 Query: 341 TYQEVLSFKP-PEPP 354 V S +P PE P Sbjct: 355 GEDSVFSHEPLPEEP 369 >2PL0-A nrPDB Length = 289 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 66/261 (25%), Positives = 117/261 (44%), Gaps = 22/261 (8%) Query: 15 KTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELR 73 + WEVP+ L+ + +G+G +G V Y KVAVK L Q + E Sbjct: 15 EDEWEVPRETLKLVERLGAGQFGEVWMGY-YNGHTKVAVKSLK---QGSMSPDAFLAEAN 70 Query: 74 LLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQ---ALSDEHVQF 129 L+K L+H+ ++ L V T +Y++T M L + +K L+ + Sbjct: 71 LMKQLQHQRLVRLYAVVTQE-------PIYIITEYMENGSLVDFLKTPSGIKLTINKLLD 123 Query: 130 LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRW- 187 + Q+ G+ +I IHRDL+ +N+ V++ +I DFGLAR D E T ++ Sbjct: 124 MAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFP 183 Query: 188 --YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSP 244 + APE + N+ + D+WS G ++ E++ G+ +PG + ++ + P Sbjct: 184 IKWTAPEAI-NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRP 242 Query: 245 EVLAKISSEHARTYIQSLPPM 265 + + + R + P Sbjct: 243 DNCPEELYQLMRLCWKERPED 263 >5AP3-A nrPDB Length = 313 Score = 200 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 77/332 (23%), Positives = 129/332 (38%), Gaps = 58/332 (17%) Query: 4 PRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLI 63 Y Q ++ + L+ +GSG V + + +Q A+K ++ Sbjct: 14 GTENLYFQSMSVKG----RIYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQ 68 Query: 64 HARRTYRELRLLKHLK--HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA 121 E+ L L+ + +I L D +Y+V DLN +K + Sbjct: 69 TLDSYRNEIAYLNKLQQHSDKIIRLYDYEIT------DQYIYMVMECGNIDLNGWLKKKK 122 Query: 122 -LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT 180 + + +L + IH GI+H DLKP+N + D L+++DFG+A Q + T Sbjct: 123 SIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTT 181 Query: 181 GY-----VATRWYRAPEIMLNWMHYNQ----------TVDIWSVGCIMAELLQGKALFPG 225 V T Y PE + + + D+WS+GCI+ + GK F Sbjct: 182 SVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ- 240 Query: 226 SDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLL 285 I+Q+ ++ ++ P+ E+ P +P+KDL D+L Sbjct: 241 -QIINQISKLHAII-DPNHEI--------------EFPDIPEKDLQ-----------DVL 273 Query: 286 GRMLVLDSDQRVSAAEALAHAYFSQYHDPEDE 317 L D QR+S E LAH Y P ++ Sbjct: 274 KCCLKRDPKQRISIPELLAHPYVQIQTHPVNQ 305 >4OLI-A nrPDB Length = 645 Score = 200 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 64/301 (21%), Positives = 113/301 (37%), Gaps = 35/301 (11%) Query: 14 NKTVWEVPQRLQGLRPVGSGAYGSVCS-AYDAR---LRQKVAVKKLSRPFQSLIHARRTY 69 + TV+ + L+ +R +G G +G V YD + VAVK L H Sbjct: 346 DPTVFH-KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADC-GPQHRSGWK 403 Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDEHVQ 128 +E+ +L+ L HE++I + LV + L + + ++ + Sbjct: 404 QEIDILRTLYHEHIIKYKGCCEDQG----EKSLQLVMEYVPLGSLRDYLPRHSIGLAQLL 459 Query: 129 FLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYV----- 183 Q+ G+ Y+HS IHR+L NV ++ D ++I DFGLA+ E Y Sbjct: 460 LFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDG 519 Query: 184 --ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGT 241 WY APE + + Y D+WS G + ELL + +E++G Sbjct: 520 DSPVFWY-APECLKEYKFY-YASDVWSFGVTLYELLT-----HCDSSQSPPTKFLELIGI 572 Query: 242 PSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAE 301 +++ ++ +P+ D L+ ++ R + Sbjct: 573 ----AQGQMTVLRLTELLERGERLPRPD------KCPCEVYHLMKNCWETEASFRPTFEN 622 Query: 302 A 302 Sbjct: 623 L 623 Score = 92.3 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 44/278 (15%), Positives = 85/278 (30%), Gaps = 57/278 (20%) Query: 41 AYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFS 100 D +V +K L + A Y L+ + H ++ + V Sbjct: 88 GRDRGQELRVVLKVLDPSHHDIALA--FYETASLMSQVSHTHLAFVHGVCVRGP------ 139 Query: 101 EVYLVTTLM-GADLNNIVKCQA--LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVA 157 E +VT + L+ ++ + + + QL L Y+ + ++H ++ N+ Sbjct: 140 ENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 199 Query: 158 VNEDCE-------LRILD--FGLARQADEEMTGYVATRWYRAPEIMLNW-MHYNQTVDIW 207 + +++ D GL + EE + + APE + + +D W Sbjct: 200 LARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLSTAMDKW 256 Query: 208 SVGCIMAEL-LQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP 266 G + E+ G+A L S + Q +P Sbjct: 257 GFGATLLEICFDGEAP------------------------LQSRSPSEKEHFYQRQHRLP 292 Query: 267 QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 + P L + L + QR S L Sbjct: 293 EPSC--------PQLATLTSQCLTYEPTQRPSFRTILR 322 >2HK5-A nrPDB Length = 270 Score = 200 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 64/266 (24%), Positives = 115/266 (43%), Gaps = 22/266 (8%) Query: 10 RQELNKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT 68 ++ K WE+P+ L+ + +G+G +G V A + KVAVK + S Sbjct: 2 QKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMS---VEAF 57 Query: 69 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKC---QALSD 124 E ++K L+H+ ++ L V T +Y++T M L + +K Sbjct: 58 LAEANVMKTLQHDKLVKLHAVVTKE-------PIYIITEFMAKGSLLDFLKSDEGSKQPL 110 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYV 183 + Q+ G+ +I IHRDL+ +N+ V+ +I DFGLAR D E T Sbjct: 111 PKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTARE 170 Query: 184 ATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVV 239 ++ + APE + N+ + D+WS G ++ E++ G+ +PG + ++ + Sbjct: 171 GAKFPIKWTAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGY 229 Query: 240 GTPSPEVLAKISSEHARTYIQSLPPM 265 P PE + ++ P Sbjct: 230 RMPRPENCPEELYNIMMRCWKNRPEE 255 >4AN9-A nrPDB Length = 301 Score = 200 bits (510), Expect = 7e-52, Method: Composition-based stats. Identities = 63/292 (21%), Positives = 121/292 (41%), Gaps = 39/292 (13%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + + +G+G G V +A K + + I + REL++L Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ-IIRELQVLHECNSP 67 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-QALSDEHVQFLVYQLLRGLKY 140 ++G F I + + G L+ ++K + ++ + + +++GL Y Sbjct: 68 YIVGFYGAFYSDGEISIC-----MEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 122 Query: 141 I-HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ-ADEEMTGYVATRWYRAPEIMLNWM 198 + I+HRD+KPSN+ VN E+++ DFG++ Q DE +V TR Y +PE + Sbjct: 123 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQG-T 181 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 HY+ DIWS+G + E+ G+ P + L I+ P P++ + + S + Sbjct: 182 HYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVN---EPPPKLPSAVFSLEFQ-- 236 Query: 259 IQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 D + + L+ + +R + + HA+ + Sbjct: 237 ------------------------DFVNKCLIKNPAERADLKQLMVHAFIKR 264 >3GQL-A nrPDB Length = 326 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 72/260 (27%), Positives = 111/260 (42%), Gaps = 41/260 (15%) Query: 18 WEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQ-------KVAVKKLSRPFQSLIHARRTY 69 WE+P+ RL +P+G GA+G V A L + KVAVK L Sbjct: 23 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATE-KDLSDLI 81 Query: 70 RELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA------- 121 E+ ++K + KH+N+I LL T + +V +L ++ + Sbjct: 82 SEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLQARRPPGLEYC 136 Query: 122 ----------LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGL 171 LS + + YQ+ RG++Y+ S IHRDL NV V ED ++I DFGL Sbjct: 137 YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGL 196 Query: 172 ARQADE------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFP 224 AR G + +W APE + + + Y D+WS G ++ E+ G + +P Sbjct: 197 ARDIHHIDYYKKTTNGRLPVKW-MAPEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYP 254 Query: 225 GSDYIDQLKRIMEVVGTPSP 244 G + K + E P Sbjct: 255 GVPVEELFKLLKEGHRMDKP 274 >2VD5-A nrPDB Length = 412 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 64/330 (19%), Positives = 117/330 (35%), Gaps = 44/330 (13%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKH 80 + L+ +G GA+ V + Q A+K +++ E +L + Sbjct: 61 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 120 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTL-MGADLNNIVKC--QALSDEHVQFLVYQLLRG 137 + L F +D + +YLV +G DL ++ + + E +F + +++ Sbjct: 121 RWITQLHFAF------QDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMA 174 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY----VATRWYRAPEI 193 + +H G +HRD+KP N+ ++ +R+ DFG + + T V T Y +PEI Sbjct: 175 IDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEI 234 Query: 194 ML------NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 247 + Y D W++G E+ G+ F + +I+ S ++ Sbjct: 235 LQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLV 294 Query: 248 AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 + E AR +IQ L P+ L R A + H + Sbjct: 295 DEGVPEEARDFIQRLLCPPETRLG------------------------RGGAGDFRTHPF 330 Query: 308 FSQYHDPEDEPEAEPYDESVEAKERTLEEW 337 F P+ E T Sbjct: 331 FFGLDWDGLRDSVPPFTPDFEGATDTCNFD 360 >2Y6O-A nrPDB Length = 291 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 54/234 (23%), Positives = 99/234 (42%), Gaps = 21/234 (8%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQK---VAVKKLSRPFQSLIHARRTYRELRLLKHLKH 80 ++ + +G G +G VCS ++ VA+K L + R E ++ H Sbjct: 16 IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTD-KQRRDFLSEASIMGQFDH 74 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQ--ALSDEHVQFLVYQLLRG 137 N+I L V T V ++T M L+ ++ + + ++ + G Sbjct: 75 PNIIHLEGVVTKCKP------VMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSG 128 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW------YRAP 191 +KY+ +HRDL N+ VN + ++ DFG++R +++ TR + AP Sbjct: 129 MKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAP 188 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSP 244 E + + + D+WS G +M E++ G+ + D +K I E P P Sbjct: 189 EAIA-YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPP 241 >2JD5-A nrPDB Length = 373 Score = 200 bits (509), Expect = 9e-52, Method: Composition-based stats. Identities = 88/348 (25%), Positives = 150/348 (43%), Gaps = 53/348 (15%) Query: 3 GPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSL 62 G ++ E K R +R +G G + +V A D VA+K + Sbjct: 5 GGFHPAFKGEPYKDA-----RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR---GDK 56 Query: 63 IHARRTYRELRLLKHLKHE-----------NVIGLLDVFTPATSIEDFSEVYLVTTLMGA 111 ++ E++LL+ + +++ LLD F + V +V ++G Sbjct: 57 VYTEAAEDEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGP--NGVHVVMVFEVLGE 114 Query: 112 DLNNIVK---CQALSDEHVQFLVYQLLRGLKYIHSA-GIIHRDLKPSNVAVN------ED 161 +L ++K + + +V+ + QLL GL Y+H GIIH D+KP NV + Sbjct: 115 NLLALIKKYEHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENL 174 Query: 162 CELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKA 221 +++I D G A DE T + TR YR+PE++L + DIWS C++ EL+ G Sbjct: 175 IQIKIADLGNACWYDEHYTNSIQTREYRSPEVLLG-APWGCGADIWSTACLIFELITGDF 233 Query: 222 LFP------GSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQS---------LPPMP 266 LF + D + +I+E++G +L + ++ RT+ S L P Sbjct: 234 LFEPDEGHSYTKDDDHIAQIIELLGELPSYLLR--NGKYTRTFFNSRGLLRNISKLKFWP 291 Query: 267 QKD-LSSIFRGANPLAI---DLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 +D L+ ++ + A D L ML LD +R A + H + Sbjct: 292 LEDVLTEKYKFSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLKD 339 >5HI2-A nrPDB Length = 283 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 63/291 (21%), Positives = 128/291 (43%), Gaps = 40/291 (13%) Query: 14 NKTVWEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYREL 72 + WE+P ++ + +GSG++G+V + VAVK L + + E+ Sbjct: 11 SSDDWEIPDGQITVGQRIGSGSFGTVYKG---KWHGDVAVKML-----TPQQLQAFKNEV 62 Query: 73 RLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQ--ALSDEHVQF 129 +L+ +H N++ + T ++ +VT G+ L + + + + Sbjct: 63 GVLRKTRHVNILLFMGYSTKP-------QLAIVTQWCEGSSLYHHLHASETKFEMKKLID 115 Query: 130 LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR-----QADEEMTGYVA 184 + Q RG+ Y+H+ IIHRDLK +N+ ++ED ++I DFGLA + Sbjct: 116 IARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSG 175 Query: 185 TRWYRAPEIM--LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRI------- 235 + + APE++ + Y+ D+++ G ++ EL+ G+ + + DQ+ + Sbjct: 176 SILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLS 235 Query: 236 --MEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDL 284 + V + P+ + ++ +E + P P+ I LA +L Sbjct: 236 PDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPR-----ILAEIEELAREL 281 >4K33-A nrPDB Length = 325 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 70/261 (26%), Positives = 110/261 (42%), Gaps = 41/261 (15%) Query: 18 WEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQK-------VAVKKLSRPFQSLIHARRTY 69 WE+ + RL +P+G GA+G V A + + VAVK L Sbjct: 31 WELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATD-KDLSDLV 89 Query: 70 RELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA------- 121 E+ ++K + KH+N+I LL T + LV +L ++ + Sbjct: 90 SEMEMMKMIGKHKNIINLLGACTQGGPL-----YVLVEYAAKGNLREFLRARRPPGLDYS 144 Query: 122 ----------LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGL 171 L+ + + YQ+ RG++Y+ S IHRDL NV V ED ++I DFGL Sbjct: 145 FDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGL 204 Query: 172 ARQAD------EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFP 224 AR E G + +W APE + + + Y D+WS G ++ E+ G + +P Sbjct: 205 ARDVHNLDYYKETTNGRLPVKW-MAPEALFDRV-YTHQSDVWSFGVLLWEIFTLGGSPYP 262 Query: 225 GSDYIDQLKRIMEVVGTPSPE 245 G + K + E P Sbjct: 263 GIPVEELFKLLKEGHRMDKPA 283 >4P5Q-A nrPDB Length = 361 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 55/230 (23%), Positives = 101/230 (43%), Gaps = 21/230 (9%) Query: 28 RPVGSGAYGSVCSAYDARLRQK---VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVI 84 + VG+G +G VCS +K VA+K L + R E ++ H N+I Sbjct: 39 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTE-KQRRDFLGEASIMGQFDHPNII 97 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQ--ALSDEHVQFLVYQLLRGLKYI 141 L V T + V +VT M L++ ++ + + ++ + G+KY+ Sbjct: 98 RLEGVVTKSKP------VMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYL 151 Query: 142 HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW------YRAPEIML 195 G +HRDL N+ +N + ++ DFGL+R +++ TR + +PE + Sbjct: 152 SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIA 211 Query: 196 NWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSP 244 + + D+WS G ++ E++ G+ + D +K + E P P Sbjct: 212 -YRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPP 260 >6E4F-A nrPDB Length = 290 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 58/253 (22%), Positives = 113/253 (44%), Gaps = 23/253 (9%) Query: 6 AGFYRQE---LNKTVWEV-PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 61 Y Q L WE+ P+ L L+ +G+G +G V R + VA+K + + Sbjct: 11 ENLYFQGTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYG-KWRGQYDVAIKMIK---EG 66 Query: 62 LIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVK-- 118 + E +++ +L HE ++ L V T I +++T M L N ++ Sbjct: 67 SMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPI------FIITEYMANGCLLNYLREM 120 Query: 119 CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ-ADE 177 + + + + ++Y+ S +HRDL N VN+ +++ DFGL+R D+ Sbjct: 121 RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDD 180 Query: 178 EMTGYVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLK 233 E T V +++ + PE+++ + ++ DIW+ G +M E+ GK + + + Sbjct: 181 EYTSSVGSKFPVRWSPPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAE 239 Query: 234 RIMEVVGTPSPEV 246 I + + P + Sbjct: 240 HIAQGLRLYRPHL 252 >3HMP-A nrPDB Length = 342 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 75/315 (23%), Positives = 126/315 (40%), Gaps = 54/315 (17%) Query: 21 PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK- 79 + L+ +GSG V + + +Q A+K ++ E+ L L+ Sbjct: 55 GRIYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 113 Query: 80 -HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-LSDEHVQFLVYQLLRG 137 + +I L D +Y+V DLN+ +K + + + +L Sbjct: 114 HSDKIIRLYDYEIT------DQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEA 167 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY-----VATRWYRAPE 192 + IH GI+H DLKP+N + D L+++DFG+A Q + T V T Y PE Sbjct: 168 VHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPE 226 Query: 193 IMLNWMHYNQ----------TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTP 242 + + + D+WS+GCI+ + GK F I+Q+ ++ ++ P Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAII-DP 283 Query: 243 SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEA 302 + E+ P +P+KDL D+L L D QR+S E Sbjct: 284 NHEI--------------EFPDIPEKDLQ-----------DVLKCCLKRDPKQRISIPEL 318 Query: 303 LAHAYFSQYHDPEDE 317 LAH Y P ++ Sbjct: 319 LAHPYVQIQTHPVNQ 333 >5TQX-A nrPDB Length = 655 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 78/288 (27%), Positives = 121/288 (42%), Gaps = 24/288 (8%) Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77 WE+ +R +G+G +G+VC L K+A+K S + R E++++K Sbjct: 10 WEMRER------LGTGGFGNVCLYQHRELDLKIAIKSCRLEL-STKNRERWCHEIQIMKK 62 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK----CQALSDEHVQFLVYQ 133 L H NV+ DV + + + G DL ++ C L + + L+ Sbjct: 63 LNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSD 122 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAV-NEDCEL--RILDFGLARQAD--EEMTGYVATRWY 188 + G++Y+H IIHRDLKP N+ + + ++ +I+D G A+ D E T +V T Y Sbjct: 123 IGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQY 182 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLA 248 APE+ N Y TVD WS G ++ E + G F + Q E + P+ + Sbjct: 183 LAPELFEN-KPYTATVDYWSFGTMVFECIAGYRPFL---HHLQPFTWHEKIKKKDPKCIF 238 Query: 249 KISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQR 296 S P P S I L ML D QR Sbjct: 239 ACEEMSGEVRFSSHLPQPNSLCSLIVEPMENW----LQLMLNWDPQQR 282 >1JPA-A nrPDB Length = 312 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 60/259 (23%), Positives = 113/259 (43%), Gaps = 30/259 (11%) Query: 7 GFYRQELNKTVWEVPQRL-----QGLRPVGSGAYGSVCSAYDARLRQK---VAVKKLSRP 58 F ++ N+ V E + + + + +G+G +G VCS + ++ VA+K L Sbjct: 13 PFTFEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSG 72 Query: 59 FQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV 117 + R E ++ H NVI L V T +T V ++T M L++ + Sbjct: 73 YTE-KQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTP------VMIITEFMENGSLDSFL 125 Query: 118 KCQ--ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA 175 + + + ++ + G+KY+ +HRDL N+ VN + ++ DFGL+R Sbjct: 126 RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFL 185 Query: 176 DEEMT---------GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPG 225 +++ + G + RW APE + + + D+WS G +M E++ G+ + Sbjct: 186 EDDTSDPTYTSALGGKIPIRW-TAPEAI-QYRKFTSASDVWSYGIVMWEVMSYGERPYWD 243 Query: 226 SDYIDQLKRIMEVVGTPSP 244 D + I + P P Sbjct: 244 MTNQDVINAIEQDYRLPPP 262 >5UUU-A nrPDB Length = 547 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 61/301 (20%), Positives = 121/301 (40%), Gaps = 44/301 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL--- 78 R +G G +G V A + A+K L + + R++ L Sbjct: 198 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 257 Query: 79 -KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-LSDEHVQFLVYQLLR 136 ++ + F + +++ + G DL+ + S+ ++F +++ Sbjct: 258 GDCPFIVCMSYAFHTPDKLS-----FILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 312 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM-TGYVATRWYRAPEIML 195 GL+++H+ +++RDLKP+N+ ++E +RI D GLA ++ V T Y APE++ Sbjct: 313 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQ 372 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 + Y+ + D +S+GC++ +LL+G + F D+ I + T + E+ Sbjct: 373 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSF----- 426 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEALAHAYFSQ 310 +P LL +L D ++R+ A E +F Sbjct: 427 ----------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 464 Query: 311 Y 311 Sbjct: 465 L 465 >3QGY-A nrPDB Length = 286 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 60/269 (22%), Positives = 111/269 (41%), Gaps = 20/269 (7%) Query: 21 PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKH 80 P L ++ +GSG +G V Y + KVA+K + S E ++ L H Sbjct: 26 PSELTFVQEIGSGQFGLVHLGYWLN-KDKVAIKTIKEGSMSEDD---FIEEAEVMMKLSH 81 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA--LSDEHVQFLVYQLLRG 137 ++ L V I LV M L++ ++ Q + E + + + G Sbjct: 82 PKLVQLYGVCLEQAPI------CLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEG 135 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ-ADEEMTGYVATRW---YRAPEI 193 + Y+ A +IHRDL N V E+ +++ DFG+ R D++ T T++ + +PE+ Sbjct: 136 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 195 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 ++ Y+ D+WS G +M E+ GK + + ++ I P + + Sbjct: 196 F-SFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVY 254 Query: 253 EHARTYIQSLPPMPQKDLSSIFRGANPLA 281 + + P + S + R +A Sbjct: 255 QIMNHCWKERPE-DRPAFSRLLRQLAEIA 282 >5MJB-A nrPDB Length = 305 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 62/287 (21%), Positives = 116/287 (40%), Gaps = 35/287 (12%) Query: 25 QGLRPVGSGAYGSVCSAYDARLRQK---VAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + +G+G +G V ++ VA+K L + S R E ++ H Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-SEKQRRDFLSEASIMGQFDHR 87 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQ--ALSDEHVQFLVYQLLRGL 138 N+I L V T + V ++T M L++ ++ + + ++ + G+ Sbjct: 88 NIIRLEGVVTKSRP------VMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGM 141 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT---------GYVATRWYR 189 KY+ +HRDL N+ VN + ++ DFGL+R ++ + G + RW Sbjct: 142 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRW-T 200 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLA 248 APE + + + D+WS G +M E++ G+ + D + I + P P Sbjct: 201 APEAIA-YRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPP---- 255 Query: 249 KISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQ 295 + Q + QKD +S R A ++ L +M+ + Sbjct: 256 ---MDCPAALHQLMLDCWQKDRNSRPRFA--EIVNTLDKMIR-NPAS 296 >3V5Q-A nrPDB Length = 297 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 63/310 (20%), Positives = 108/310 (34%), Gaps = 68/310 (21%) Query: 22 QRLQGLRPVGSGAYGSVCSAYD-----ARLRQKVAVKKLSRPFQSLIHARRTYRELRLLK 76 + + R +G GA+G V A + + VAVK L P L + RE LL Sbjct: 15 RDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPT--LAARKDFQREAELLT 72 Query: 77 HLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA-------------- 121 +L+HE+++ V D + +V M DLN ++ Sbjct: 73 NLQHEHIVKFYGVC------GDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQA 126 Query: 122 ---LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE 178 L + + Q+ G+ Y+ S +HRDL N V + ++I DFG++R Sbjct: 127 KGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYST 186 Query: 179 MTGYVA-----TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQL 232 V + PE ++ + + D+WS G I+ E+ GK + + + Sbjct: 187 DYYRVGGHTMLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI 245 Query: 233 KRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLD 292 + I + P V K D++ + Sbjct: 246 ECITQGRVLERPRVCPK------------------------------EVYDVMLGCWQRE 275 Query: 293 SDQRVSAAEA 302 QR++ E Sbjct: 276 PQQRLNIKEI 285 >3PVW-A nrPDB Length = 695 Score = 197 bits (502), Expect = 4e-51, Method: Composition-based stats. Identities = 61/301 (20%), Positives = 121/301 (40%), Gaps = 44/301 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL--- 78 R +G G +G V A + A+K L + + R++ L Sbjct: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 Query: 79 -KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-LSDEHVQFLVYQLLR 136 ++ + F + +++ + G DL+ + S+ ++F +++ Sbjct: 249 GDCPFIVCMSYAFHTPDKLS-----FILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM-TGYVATRWYRAPEIML 195 GL+++H+ +++RDLKP+N+ ++E +RI D GLA ++ V T Y APE++ Sbjct: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQ 363 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 + Y+ + D +S+GC++ +LL+G + F D+ I + T + E+ Sbjct: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSF----- 417 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEALAHAYFSQ 310 +P LL +L D ++R+ A E +F Sbjct: 418 ----------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 Query: 311 Y 311 Sbjct: 456 L 456 >5AMN-A nrPDB Length = 299 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 71/303 (23%), Positives = 123/303 (40%), Gaps = 41/303 (13%) Query: 13 LNKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQK-----VAVKKLSRPFQSLIHAR 66 L WE P++ L + +G G +G V A L+ + VAVK L + S R Sbjct: 13 LEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML-KENASPSELR 71 Query: 67 RTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC------- 119 E +LK + H +VI L + + + +V L ++ Sbjct: 72 DLLSEFNVLKQVNHPHVIKLYGACSQDGPL-----LLIVEYAKYGSLRGFLRESRKVGPG 126 Query: 120 ----QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA 175 +AL+ + +Q+ +G++Y+ ++HRDL N+ V E +++I DFGL+R Sbjct: 127 YPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV 186 Query: 176 DEEMT------GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDY 228 EE + G + +W A E + + + Y D+WS G ++ E++ G +PG Sbjct: 187 YEEDSYVKRSQGRIPVKW-MAIESLFDHI-YTTQSDVWSFGVLLWEIVTLGGNPYPGIPP 244 Query: 229 IDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRM 288 + P+ S E R +Q P K ++ DL +M Sbjct: 245 ERLFNLLKTGHRMERPD---NCSEEMYRLMLQCWKQEPDKR-----PVFADISKDL-EKM 295 Query: 289 LVL 291 +V Sbjct: 296 MVK 298 >3CJF-A nrPDB Length = 309 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 74/323 (22%), Positives = 131/323 (40%), Gaps = 63/323 (19%) Query: 10 RQELNKTVWEVPQ-RLQGLRPVGSGAYGSVCSA----YDAR-LRQKVAVKKLSRPFQSLI 63 R + + WE P+ RL +P+G GA+G V A D + VAVK L Sbjct: 14 RLPYDASKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE 73 Query: 64 HARRTYRELRLLKHLKHE-NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA- 121 H R EL++L H+ H NV+ LL T + +V +L+ ++ + Sbjct: 74 H-RALMSELKILIHIGHHLNVVNLLGACTKPG----GPLMVIVEFCKFGNLSTYLRSKRN 128 Query: 122 ------------LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDF 169 L+ EH+ +Q+ +G++++ S IHRDL N+ ++E ++I DF Sbjct: 129 EFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDF 188 Query: 170 GLARQADEEMTGYV-ATRW----YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALF 223 GLAR ++ + APE + + + Y D+WS G ++ E+ G + + Sbjct: 189 GLARDIYKDPDYVRKGDARLPLKWMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPY 247 Query: 224 PGSDYIDQL-KRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAI 282 PG ++ +R+ E +P+ + E +T + Sbjct: 248 PGVKIDEEFCRRLKEGTRMRAPDYT---TPEMYQTMLD---------------------- 282 Query: 283 DLLGRMLVLDSDQRVSAAEALAH 305 + QR + +E + H Sbjct: 283 -----CWHGEPSQRPTFSELVEH 300 >2PSQ-A nrPDB Length = 370 Score = 197 bits (501), Expect = 7e-51, Method: Composition-based stats. Identities = 76/307 (24%), Positives = 123/307 (40%), Gaps = 50/307 (16%) Query: 18 WEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQK-------VAVKKLSRPFQSLIHARRTY 69 WE P+ +L +P+G G +G V A + + VAVK L Sbjct: 76 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATE-KDLSDLV 134 Query: 70 RELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA------- 121 E+ ++K + KH+N+I LL T + +V +L ++ + Sbjct: 135 SEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLRARRPPGMEYS 189 Query: 122 ----------LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGL 171 ++ + + YQL RG++Y+ S IHRDL NV V E+ ++I DFGL Sbjct: 190 YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL 249 Query: 172 ARQADE------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFP 224 AR + G + +W APE + + + Y D+WS G +M E+ G + +P Sbjct: 250 ARDINNIDYYKKTTNGRLPVKW-MAPEALFDRV-YTHQSDVWSFGVLMWEIFTLGGSPYP 307 Query: 225 GSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDL 284 G + K + E P A ++E +P + L DL Sbjct: 308 GIPVEELFKLLKEGHRMDKP---ANCTNELYMMMRDCWHAVPSQR-----PTFKQLVEDL 359 Query: 285 LGRMLVL 291 R+L L Sbjct: 360 -DRILTL 365 >3QA8-A nrPDB Length = 676 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 62/216 (28%), Positives = 99/216 (45%), Gaps = 18/216 (8%) Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77 WE+ +R +G+G +G V ++VA+K+ + S + R E++++K Sbjct: 16 WEMKER------LGTGGFGYVLRWIHQDTGEQVAIKQCRQEL-SPKNRERWCLEIQIMKK 68 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVK----CQALSDEHVQFLVY 132 L H NV+ +V + L G DL + C L + ++ L+ Sbjct: 69 LNHPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLS 128 Query: 133 QLLRGLKYIHSAGIIHRDLKPSNVAVN---EDCELRILDFGLARQAD--EEMTGYVATRW 187 + L+Y+H IIHRDLKP N+ + + +I+D G A++ D E T +V T Sbjct: 129 DISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQ 188 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALF 223 Y APE +L Y TVD WS G + E + G F Sbjct: 189 YLAPE-LLEQKKYTVTVDYWSFGTLAFECITGFRPF 223 >5HIE-A nrPDB Length = 302 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 60/274 (21%), Positives = 121/274 (44%), Gaps = 35/274 (12%) Query: 14 NKTVWEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYREL 72 + WE+P ++ + +GSG++G+V + VAVK L + + E+ Sbjct: 27 SSDDWEIPDGQITVGQRIGSGSFGTVYKG---KWHGDVAVKML-----TPQQLQAFKNEV 78 Query: 73 RLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVK--CQALSDEHVQF 129 +L+ +H N++ + T ++ +VT G+ L + + + Sbjct: 79 GVLRKTRHVNILLFMGYSTKP-------QLAIVTQWCEGSSLYHHLHIIETKFEMIKLID 131 Query: 130 LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR-----QADEEMTGYVA 184 + Q +G+ Y+H+ IIHRDLK +N+ ++ED ++I DFGLA + Sbjct: 132 IARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSG 191 Query: 185 TRWYRAPEIM--LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQ---------LK 233 + + APE++ + Y+ D+++ G ++ EL+ G+ + + DQ L Sbjct: 192 SILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLS 251 Query: 234 RIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQ 267 + V + P+ + ++ +E + P PQ Sbjct: 252 PDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQ 285 >5X02-A nrPDB Length = 347 Score = 197 bits (500), Expect = 9e-51, Method: Composition-based stats. Identities = 63/266 (23%), Positives = 110/266 (41%), Gaps = 44/266 (16%) Query: 9 YRQELNKTVWEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQ-----KVAVKKLSRPFQSL 62 +R+ WE P + L+ + +GSGA+G V +A + + +VAVK L S Sbjct: 34 FREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADS- 92 Query: 63 IHARRTYRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV--KC 119 EL+++ L HEN++ LL T + I + DL N + K Sbjct: 93 SEREALMSELKMMTQLGSHENIVNLLGACTLSGPI-----YLIFEYCCYGDLLNYLRSKR 147 Query: 120 QALSDEHVQF----------------------LVYQLLRGLKYIHSAGIIHRDLKPSNVA 157 + S++ +++ YQ+ +G++++ +HRDL NV Sbjct: 148 EKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVL 207 Query: 158 VNEDCELRILDFGLARQADEEMTGYV-ATRW----YRAPEIMLNWMHYNQTVDIWSVGCI 212 V ++I DFGLAR + V + APE + + Y D+WS G + Sbjct: 208 VTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGI-YTIKSDVWSYGIL 266 Query: 213 MAELLQ-GKALFPGSDYIDQLKRIME 237 + E+ G +PG ++++ Sbjct: 267 LWEIFSLGVNPYPGIPVDANFYKLIQ 292 >5L6P-A nrPDB Length = 298 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 50/233 (21%), Positives = 96/233 (41%), Gaps = 19/233 (8%) Query: 25 QGLRPVGSGAYGSVCSAYDARLRQK---VAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + +G+G +G VC + ++ VA+K L + R E ++ H Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTE-RQRRDFLSEASIMGQFDHP 80 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYI 141 N+I L V T + + +E D + + + ++ + G+KY+ Sbjct: 81 NIIRLEGVVTKSRPVMILTEF---MENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYL 137 Query: 142 HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT---------GYVATRWYRAPE 192 +HRDL N+ VN + ++ DFGL+R +++ + G + RW APE Sbjct: 138 SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRW-TAPE 196 Query: 193 IMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSP 244 + + + D+WS G +M E++ G+ + D + + + P P Sbjct: 197 AIA-YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPP 248 >4XI2-A nrPDB Length = 446 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 56/244 (22%), Positives = 111/244 (45%), Gaps = 20/244 (8%) Query: 12 ELNKTVWEV-PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR 70 L WE+ P+ L L+ +G+G +G V R + VA+K + + + Sbjct: 176 GLGYGSWEIDPKDLTFLKELGTGQFGVVKYG-KWRGQYDVAIKMIR---EGSMSEDEFIE 231 Query: 71 ELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVK--CQALSDEHV 127 E +++ +L HE ++ L V T I +++T M L N ++ + + Sbjct: 232 EAKVMMNLSHEKLVQLYGVCTKQRPI------FIITEYMANGCLLNYLREMRHRFQTQQL 285 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ-ADEEMTGYVATR 186 + + ++Y+ S +HRDL N VN+ +++ DFGL+R D+E T V ++ Sbjct: 286 LEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSK 345 Query: 187 W---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTP 242 + + PE+++ + ++ DIW+ G +M E+ GK + + + I + + Sbjct: 346 FPVRWSPPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLY 404 Query: 243 SPEV 246 P + Sbjct: 405 RPHL 408 >4XUF-A nrPDB Length = 297 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 63/258 (24%), Positives = 108/258 (41%), Gaps = 46/258 (17%) Query: 18 WEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQ-----KVAVKKLSRPFQSLIHARRTYRE 71 WE P + L+ + +GSGA+G V +A + + +VAVK L S E Sbjct: 4 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADS-SEREALMSE 62 Query: 72 LRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV--KCQALSDEHVQ 128 L+++ L HEN++ LL T + I + DL N + K + S++ ++ Sbjct: 63 LKMMTQLGSHENIVNLLGACTLSGPI-----YLIFEYCCYGDLLNYLRSKREKFSEDEIE 117 Query: 129 F----------------------LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRI 166 + YQ+ +G++++ +HRDL NV V ++I Sbjct: 118 YENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKI 177 Query: 167 LDFGLARQADEEMTGYV------ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-G 219 DFGLAR + V +W APE + + Y D+WS G ++ E+ G Sbjct: 178 CDFGLARDIMSDSNYVVRGNARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFSLG 235 Query: 220 KALFPGSDYIDQLKRIME 237 +PG ++++ Sbjct: 236 VNPYPGIPVDANFYKLIQ 253 >2ZMD-A nrPDB Length = 390 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 74/315 (23%), Positives = 125/315 (39%), Gaps = 54/315 (17%) Query: 21 PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK- 79 + L+ +GSG V + + +Q A+K ++ E+ L L+ Sbjct: 55 GRIYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 113 Query: 80 -HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-LSDEHVQFLVYQLLRG 137 + +I L D +Y+V DLN+ +K + + + +L Sbjct: 114 HSDKIIRLYDYEIT------DQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEA 167 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY-----VATRWYRAPE 192 + IH GI+H DLKP+N + D L+++DFG+A Q + T V Y PE Sbjct: 168 VHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPE 226 Query: 193 IMLNWMHYNQ----------TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTP 242 + + + D+WS+GCI+ + GK F I+Q+ ++ ++ P Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAII-DP 283 Query: 243 SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEA 302 + E+ P +P+KDL D+L L D QR+S E Sbjct: 284 NHEI--------------EFPDIPEKDLQ-----------DVLKCCLKRDPKQRISIPEL 318 Query: 303 LAHAYFSQYHDPEDE 317 LAH Y P ++ Sbjct: 319 LAHPYVQIQTHPVNQ 333 >4Y93-A nrPDB Length = 446 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 55/244 (22%), Positives = 111/244 (45%), Gaps = 20/244 (8%) Query: 12 ELNKTVWEV-PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR 70 L WE+ P+ L L+ +G+G +G V R + VA+K + + + Sbjct: 177 GLGYGSWEIDPKDLTFLKELGTGQFGVVKYG-KWRGQYDVAIKMIK---EGSMSEDEFIE 232 Query: 71 ELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVK--CQALSDEHV 127 E +++ +L HE ++ L V T I +++T M L N ++ + + Sbjct: 233 EAKVMMNLSHEKLVQLYGVCTKQRPI------FIITEYMANGCLLNYLREMRHRFQTQQL 286 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ-ADEEMTGYVATR 186 + + ++Y+ S +HRDL N VN+ +++ DFG+ R D+E T ++ Sbjct: 287 LEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSK 346 Query: 187 W---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTP 242 + + +PE+++ + ++ DIW+ G +M E+ GK + + + I + + P Sbjct: 347 FPVKWASPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLP 405 Query: 243 SPEV 246 P + Sbjct: 406 RPHL 409 >5EG3-A nrPDB Length = 334 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 78/307 (25%), Positives = 125/307 (40%), Gaps = 50/307 (16%) Query: 18 WEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQK-------VAVKKLSRPFQSLIHARRTY 69 WE P+ +L +P+G GA+G V A + + VAVK L Sbjct: 30 WEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATE-KDLSDLV 88 Query: 70 RELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA------- 121 E+ ++K + KH+N+I LL T + +V +L ++ + Sbjct: 89 SEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVAYASKGNLREYLRARRPPGMELS 143 Query: 122 ----------LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGL 171 ++ + + YQL RG++Y+ S IHRDL NV V E+ ++I DFGL Sbjct: 144 PDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL 203 Query: 172 ARQAD------EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFP 224 AR + E G + +W APE + + + Y D+WS G +M E+ G + +P Sbjct: 204 ARDINNIDFFKETTNGRLPVKW-MAPEALFDRV-YTHQSDVWSFGVLMWEIFTLGGSPYP 261 Query: 225 GSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDL 284 G + K + E P A ++E +P + L DL Sbjct: 262 GIPVEELFKLLKEGHRMDKP---ANCTNELYMMMRDCWHAVPSQR-----PTFKQLVEDL 313 Query: 285 LGRMLVL 291 R+L L Sbjct: 314 -DRILTL 319 >3C51-A nrPDB Length = 543 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 119/302 (39%), Gaps = 49/302 (16%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA-RRTYRELRLLKHLKHEN 82 R +G G +G V + + A KKL++ + E ++L + Sbjct: 187 FLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRF 246 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV-----KCQALSDEHVQFLVYQLLR 136 ++ L F T ++ LV T+M G D+ + + F Q++ Sbjct: 247 IVSLAYAFETKT------DLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVS 300 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLA---RQADEEMTGYVATRWYRAPEI 193 GL+++H II+RDLKP NV +++D +RI D GLA + + GY T + APE+ Sbjct: 301 GLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPEL 360 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSE 253 +L Y+ +VD +++G + E++ + F + K + + V E Sbjct: 361 LLGEE-YDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRV------------LE 407 Query: 254 HARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEALAHAYF 308 A TY +P + D +L D ++R+ S H F Sbjct: 408 QAVTYPDKF---------------SPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLF 452 Query: 309 SQ 310 Sbjct: 453 RD 454 >1AD5-A nrPDB Length = 438 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 62/265 (23%), Positives = 113/265 (42%), Gaps = 30/265 (11%) Query: 10 RQELNKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT 68 ++ K WE+P+ L+ + +G+G +G V A + KVAVK + S Sbjct: 169 QKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMS---VEAF 224 Query: 69 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKC---QALSD 124 E ++K L+H+ ++ L V T +Y++T M L + +K Sbjct: 225 LAEANVMKTLQHDKLVKLHAVVTKE-------PIYIITEFMAKGSLLDFLKSDEGSKQPL 277 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVA 184 + Q+ G+ +I IHRDL+ +N+ V+ +I DFGLAR V Sbjct: 278 PKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLAR---------VG 328 Query: 185 TRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVG 240 ++ + APE + N+ + D+WS G ++ E++ G+ +PG + ++ + Sbjct: 329 AKFPIKWTAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYR 387 Query: 241 TPSPEVLAKISSEHARTYIQSLPPM 265 P PE + ++ P Sbjct: 388 MPRPENCPEELYNIMMRCWKNRPEE 412 >2R2P-A nrPDB Length = 295 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 58/234 (24%), Positives = 102/234 (43%), Gaps = 21/234 (8%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQK---VAVKKLSRPFQSLIHARRTYRELRLLKHLKH 80 + R +G+G +G VCS ++ VA+K L + R E ++ H Sbjct: 24 ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTE-KQRRDFLGEASIMGQFDH 82 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQ--ALSDEHVQFLVYQLLRG 137 N+I L V T + V +VT M L+ +K + + ++ + G Sbjct: 83 PNIIHLEGVVTKSKP------VMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAG 136 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW------YRAP 191 +KY+ G +HRDL N+ +N + ++ DFGL+R +++ TR + AP Sbjct: 137 MKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAP 196 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSP 244 E + + + D+WS G +M E++ G+ + D +K + E PSP Sbjct: 197 EAIA-FRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSP 249 >4XLV-A nrPDB Length = 328 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 62/323 (19%), Positives = 116/323 (35%), Gaps = 68/323 (21%) Query: 16 TVWEVP-QRLQGLRPVGSGAYGSVCS--AYDARLRQ---KVAVKKLSRPFQSLIHARRTY 69 WEV +++ LR +G G++G V A D + +VAVK ++ SL Sbjct: 32 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESA-SLRERIEFL 90 Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVK---------- 118 E ++K +V+ LL V + +V LM DL + ++ Sbjct: 91 NEASVMKGFTCHHVVRLLGVVSKGQPT------LVVMELMAHGDLKSYLRSLRPEAENNP 144 Query: 119 -CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE 177 + + + + ++ G+ Y+++ +HRDL N V D ++I DFG+ R E Sbjct: 145 GRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE 204 Query: 178 EMTGYVATRW-----YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQ 231 + + APE + + + + + D+WS G ++ E+ + + G Sbjct: 205 TDYYRKGGKGLLPVRWMAPESLKDGV-FTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQV 263 Query: 232 LKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVL 291 LK +M+ P+ DL+ Sbjct: 264 LKFVMDGGYLDQPD------------------------------NCPERVTDLMRMCWQF 293 Query: 292 DSDQRVSAAEALA------HAYF 308 + + R + E + H F Sbjct: 294 NPNMRPTFLEIVNLLKDDLHPSF 316 >4R7H-A nrPDB Length = 343 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 68/310 (21%), Positives = 115/310 (37%), Gaps = 46/310 (14%) Query: 10 RQELNKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQ-----KVAVKKLSRPFQSLI 63 Q WE P+ LQ + +G+GA+G V A L + KVAVK L + Sbjct: 37 TQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHAD 95 Query: 64 HARRTYRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC--- 119 EL+++ HL +HEN++ LL T + + + DL N ++ Sbjct: 96 EKEALMSELKIMSHLGQHENIVNLLGACTHGGPV-----LVITEYCTYGDLLNFLRRKAE 150 Query: 120 ---------------------QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAV 158 + L + Q+ +G+ ++ S IHRD+ NV + Sbjct: 151 AMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLL 210 Query: 159 NEDCELRILDFGLARQADEEMTGYV------ATRWYRAPEIMLNWMHYNQTVDIWSVGCI 212 +I DFGLAR + V +W APE + + + Y D+WS G + Sbjct: 211 TNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKW-MAPESIFDSV-YTVQSDVWSYGIL 268 Query: 213 MAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLS 271 + E+ G +PG + ++++ + A + +L P + Sbjct: 269 LWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQ 328 Query: 272 SIFRGANPLA 281 I A Sbjct: 329 QITSFLQEQA 338 >5KMM-A nrPDB Length = 329 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 62/313 (19%), Positives = 106/313 (33%), Gaps = 68/313 (21%) Query: 19 EVPQRLQGLR-PVGSGAYGSVCSAYDARL-----RQKVAVKKLSRPFQSLIHARRTYREL 72 + +R L+ +G GA+G V A L + VAVK L +S + RE Sbjct: 31 HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA--RQDFQREA 88 Query: 73 RLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA---------- 121 LL L+H++++ V T + +V M DLN ++ Sbjct: 89 ELLTMLQHQHIVRFFGVCTEGRP------LLMVFEYMRHGDLNRFLRSHGPDAKLLAGGE 142 Query: 122 ------LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA 175 L + + Q+ G+ Y+ +HRDL N V + ++I DFG++R Sbjct: 143 DVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDI 202 Query: 176 DEEMTGYVATR-----WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYI 229 V R + PE +L + + D+WS G ++ E+ GK + Sbjct: 203 YSTDYYRVGGRTMLPIRWMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNT 261 Query: 230 DQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRML 289 + + I + P R P ++ Sbjct: 262 EAIDCITQGRELERP------------------------------RACPPEVYAIMRGCW 291 Query: 290 VLDSDQRVSAAEA 302 + QR S + Sbjct: 292 QREPQQRHSIKDV 304 >4WUA-A nrPDB Length = 401 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 82/365 (22%), Positives = 143/365 (39%), Gaps = 84/365 (23%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKH-- 80 R +R +G G + +V ++D + ++ VA+K + + + E+RLLK +++ Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK---SAEHYTETALDEIRLLKSVRNSD 98 Query: 81 EN------VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV---KCQALSDEHVQFLV 131 N V+ LLD F + + + + +V ++G L + Q L V+ ++ Sbjct: 99 PNDPNREMVVQLLDDFKISGV--NGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKII 156 Query: 132 YQLLRGLKYIHSA-GIIHRDLKPSNVAVN------------------------------- 159 Q+L+GL Y+H+ IIH D+KP N+ ++ Sbjct: 157 QQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVST 216 Query: 160 ------------------EDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYN 201 E +++I D G A + T + TR YR+ E+++ YN Sbjct: 217 APATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIG-SGYN 275 Query: 202 QTVDIWSVGCIMAELLQGKALFPGSD------YIDQLKRIMEVVGTPSPEVL--AKISSE 253 DIWS C+ EL G LF D + I+E++G +++ K S E Sbjct: 276 TPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKE 335 Query: 254 HARTYIQSLPPMPQKDLS------SIFRGANPLA---IDLLGRMLVLDSDQRVSAAEALA 304 K + + A D L ML L ++R +AAE L Sbjct: 336 FFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLR 395 Query: 305 HAYFS 309 H + + Sbjct: 396 HPWLN 400 >4AT3-A nrPDB Length = 299 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 64/295 (21%), Positives = 113/295 (38%), Gaps = 40/295 (13%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARL-----RQKVAVKKLSRPFQSLIHARRTYRELRLLK 76 + R +G GA+G V A L + VAVK L + + +RE LL Sbjct: 13 HNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA--RKDFHREAELLT 70 Query: 77 HLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA-------------- 121 +L+HE+++ V + +V M DLN ++ Sbjct: 71 NLQHEHIVKFYGVCVEGDP------LIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTE 124 Query: 122 LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTG 181 L+ + + Q+ G+ Y+ S +HRDL N V E+ ++I DFG++R Sbjct: 125 LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYY 184 Query: 182 YVA-----TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRI 235 V + PE ++ + + D+WS+G ++ E+ GK + + ++ I Sbjct: 185 RVGGHTMLPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECI 243 Query: 236 MEVVGTPSPEVLAKISSEHARTYIQSLPPMPQK-----DLSSIFRGANPLAIDLL 285 + P + E Q P M + L A+P+ +D+L Sbjct: 244 TQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDIL 298 >5X5O-A nrPDB Length = 310 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 63/289 (21%), Positives = 113/289 (39%), Gaps = 54/289 (18%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 LQ G G++GSV A ++VAVKKL + +E +L L H Sbjct: 15 DDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK----------IEKEAEILSVLSHR 64 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIV---KCQALSDEHVQFLVYQLLRG 137 N+I V + +VT L + + + + + +H+ + +G Sbjct: 65 NIIQFYGVILEPPN------YGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKG 118 Query: 138 LKYIHSA---GIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT-GYVATRWYRAPEI 193 + Y+H +IHRDLK NV + D L+I DFG +R + V T + APE+ Sbjct: 119 MHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEV 178 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSE 253 + + + ++T D +S G ++ E+L + F G + + ++E Sbjct: 179 IQS-LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVE---------------- 221 Query: 254 HARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEA 302 + + +I +LL + D+ +R S + Sbjct: 222 -------------KNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQI 257 >2VWV-A nrPDB Length = 302 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 64/294 (21%), Positives = 120/294 (40%), Gaps = 36/294 (12%) Query: 25 QGLRPVGSGAYGSVCSAYDARLRQK---VAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + +G+G +G VC +K VA+K L + R E ++ +H Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTE-RQRREFLSEASIMGQFEHP 77 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVK--CQALSDEHVQFLVYQLLRGL 138 N+I L V T + V ++T M L++ ++ + + ++ + G+ Sbjct: 78 NIIRLEGVVT------NSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGM 131 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT---------GYVATRWYR 189 +Y+ +HRDL N+ VN + ++ DFGL+R +E + G + RW Sbjct: 132 RYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRW-T 190 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLA 248 APE + + + D WS G +M E++ G+ + D + I + P P Sbjct: 191 APEAIA-FRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPP---- 245 Query: 249 KISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQ-RVSAAE 301 + + Q + QKD ++ R P + L +M+ + ++ A E Sbjct: 246 ---PDCPTSLHQLMLDCWQKDRNARPRF--PQVVSALDKMIR-NPASLKIVARE 293 >3DKO-A nrPDB Length = 318 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 55/234 (23%), Positives = 100/234 (42%), Gaps = 21/234 (8%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQK---VAVKKLSRPFQSLIHARRTYRELRLLKHLKH 80 ++ R +G+G +G VCS ++ VA+K L + R E ++ H Sbjct: 45 IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTE-KQRRDFLCEASIMGQFDH 103 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQ--ALSDEHVQFLVYQLLRG 137 NV+ L V T V +V M L+ ++ + + ++ + G Sbjct: 104 PNVVHLEGVVTRGKP------VMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAG 157 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW------YRAP 191 ++Y+ G +HRDL N+ VN + ++ DFGL+R +++ T + AP Sbjct: 158 MRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAP 217 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSP 244 E + + + D+WS G +M E++ G+ + D +K I E P+P Sbjct: 218 EAI-QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAP 270 >1S9I-A nrPDB Length = 354 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 69/310 (22%), Positives = 122/310 (39%), Gaps = 29/310 (9%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + + +G+G G V +A K + + I + REL++L Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQ-IIRELQVLHECNSP 74 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK-CQALSDEHVQFLVYQLLRGLKY 140 ++G F I + + G L+ ++K + + +E + + +LRGL Y Sbjct: 75 YIVGFYGAFYSDGEISIC-----MEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAY 129 Query: 141 IHSAG-IIHRDLKPSNVAVNEDCELRILDFGLARQ-ADEEMTGYVATRWYRAPEIMLNWM 198 + I+HRD+KPSN+ VN E+++ DFG++ Q D +V TR Y APE + Sbjct: 130 LREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQG-T 188 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLA---------- 248 HY+ DIWS+G + EL G+ P D + L+ I E Sbjct: 189 HYSVQSDIWSMGLSLVELAVGRYPIPPPDAKE-LEAIFGRPVVDGEEGEPHSISPRPRPP 247 Query: 249 -------KISSEHARTYIQSLPPMPQKDLSSIFRGA-NPLAIDLLGRMLVLDSDQRVSAA 300 + S A + L + + + G P + + + L+ + +R Sbjct: 248 GRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLK 307 Query: 301 EALAHAYFSQ 310 H + + Sbjct: 308 MLTNHTFIKR 317 >2X7G-A nrPDB Length = 389 Score = 193 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 81/363 (22%), Positives = 138/363 (38%), Gaps = 82/363 (22%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK--- 79 R +R +G G + +V +D + ++ VA+K + + + E++LLK ++ Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK---SAQHYTETALDEIKLLKCVRESD 88 Query: 80 --HEN---VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV---KCQALSDEHVQFLV 131 N V+ L+D F S + V +V ++G L + Q L V+ ++ Sbjct: 89 PSDPNKDMVVQLIDDF--KISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSII 146 Query: 132 YQLLRGLKYIHSA-GIIHRDLKPSNVAV-------------------------------- 158 Q+L+GL Y+HS IIH D+KP N+ + Sbjct: 147 RQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVST 206 Query: 159 ---------------NEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQT 203 + ++I D G A + T + TR YR+ E+++ Y+ Sbjct: 207 APAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIG-AGYSTP 265 Query: 204 VDIWSVGCIMAELLQGKALFPGSD------YIDQLKRIMEVVGTPS--PEVLAKISSEHA 255 DIWS C+ EL G LF D + I+E++G+ + K S E Sbjct: 266 ADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFF 325 Query: 256 RTYIQSLPPMPQKDLS------SIFRGANPLA---IDLLGRMLVLDSDQRVSAAEALAHA 306 + K S + + A D L ML + ++R SA E L H Sbjct: 326 NRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHP 385 Query: 307 YFS 309 + + Sbjct: 386 WLN 388 >6BXI-A nrPDB Length = 333 Score = 193 bits (492), Expect = 8e-50, Method: Composition-based stats. Identities = 60/288 (20%), Positives = 104/288 (36%), Gaps = 48/288 (16%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKH 80 + + L+ +G GA+G V A+K L + E +L Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 65 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV-KCQALSDEHVQFLVYQLLRGL 138 V+ + F +D +YL+ + G D+ ++ K L++E QF + + + + Sbjct: 66 LWVVKMFYSF------QDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAI 119 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTG----------------- 181 IH G IHRD+KP N+ ++ +++ DFGL + Sbjct: 120 DSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ 179 Query: 182 ---------------------YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGK 220 V T Y APE+ + YN+ D WS+G IM E+L G Sbjct: 180 NMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFM-QTGYNKLCDWWSLGVIMYEMLIGY 238 Query: 221 ALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQK 268 F + K++M T + IS + ++ + Sbjct: 239 PPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHR 286 >3ORP-A nrPDB Length = 311 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 60/277 (21%), Positives = 116/277 (41%), Gaps = 16/277 (5%) Query: 19 EVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPF-QSLIHARRTYRELRLLKH 77 + R + +G G V A D R + VAVK L + R RE + Sbjct: 9 HLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAA 68 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVKCQA-LSDEHVQFLVYQLL 135 L H ++ + D T Y+V + L +IV + ++ + ++ Sbjct: 69 LNHPAIVAVYDTGEAETPAGPLP--YIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADAC 126 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE------EMTGYVATRWYR 189 + L + H GIIHRD+KP+N+ ++ ++++DFG+AR + + + T Y Sbjct: 127 QALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYL 186 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249 +PE + D++S+GC++ E+L G+ F G + + + P Sbjct: 187 SPE-QARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEG 245 Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLG 286 +S++ +++L P+ ++ A + DL+ Sbjct: 246 LSADLDAVVLKALAKNPENR----YQTAAEMRADLVR 278 >4E20-A nrPDB Length = 290 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 63/297 (21%), Positives = 110/297 (37%), Gaps = 35/297 (11%) Query: 14 NKTVWEVPQRLQGLRPVGSGAYGSVCS-AYDAR---LRQKVAVKKLSRPFQSLIHARRTY 69 + TV+ + L+ +R +G G +G V YD + VAVK L + + Sbjct: 1 DPTVFH-KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSG-WQ 58 Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDEHVQ 128 RE+ +L+ L HE+++ V LV + L + + + + Sbjct: 59 REIEILRTLYHEHIVKYKGCCEDQG----EKSVQLVMEYVPLGSLRDYLPRHCVGLAQLL 114 Query: 129 FLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYV----- 183 Q+ G+ Y+H+ IHR L NV ++ D ++I DFGLA+ E Y Sbjct: 115 LFAQQICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDG 174 Query: 184 --ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGT 241 WY APE + Y D+WS G + ELL + E++G Sbjct: 175 DSPVFWY-APECLKECKFY-YASDVWSFGVTLYELLT-----YCDSNQSPHTKFTELIG- 226 Query: 242 PSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS 298 +++ ++ +P+ D L+ ++ R + Sbjct: 227 ---HTQGQMTVLRLTELLERGERLPRPD------RCPCEIYHLMKNCWETEASFRPT 274 >5GRN-A nrPDB Length = 356 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 76/315 (24%), Positives = 126/315 (40%), Gaps = 57/315 (18%) Query: 14 NKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQ-----KVAVKKLSRPFQSLIHARR 67 + WE P+ L R +GSGA+G V L + KVAVK L +P + Sbjct: 37 YDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKML-KPTARSSEKQA 95 Query: 68 TYRELRLLKHLK-HENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKC------ 119 EL+++ HL H N++ LL T + I Y++T DL N + Sbjct: 96 LMSELKIMTHLGPHLNIVNLLGACTKSGPI------YIITEYCFYGDLVNYLHKNRDSFL 149 Query: 120 ---------------------QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAV 158 + L+ + YQ+ RG++++ S +HRDL NV + Sbjct: 150 SHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLL 209 Query: 159 NEDCELRILDFGLARQADEEMT------GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCI 212 + ++I DFGLAR + ++ +W APE + + + Y D+WS G + Sbjct: 210 AQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKW-MAPESIFDNL-YTTLSDVWSYGIL 267 Query: 213 MAELLQ-GKALFPGSDYIDQ-LKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDL 270 + E+ G +PG +I P+ +SE ++ P+K Sbjct: 268 LWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDH---ATSEVYEIMVKCWNSEPEKRP 324 Query: 271 SSIFRGANPLAIDLL 285 S F + + +LL Sbjct: 325 S--FYHLSEIVENLL 337 >5FM2-A nrPDB Length = 355 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 71/317 (22%), Positives = 123/317 (38%), Gaps = 55/317 (17%) Query: 13 LNKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQK-----VAVKKLSRPFQSLIHAR 66 L WE P++ L + +G G +G V A L+ + VAVK L + S R Sbjct: 54 LEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML-KENASPSELR 112 Query: 67 RTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC------- 119 E +LK + H +VI L + + + +V L ++ Sbjct: 113 DLLSEFNVLKQVNHPHVIKLYGACSQDGPL-----LLIVEYAKYGSLRGFLRESRKVGPG 167 Query: 120 ------------------QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED 161 +AL+ + +Q+ +G++Y+ ++HRDL N+ V E Sbjct: 168 YLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEG 227 Query: 162 CELRILDFGLARQADEEMT------GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAE 215 +++I DFGL+R EE + G + +W A E + + + Y D+WS G ++ E Sbjct: 228 RKMKISDFGLSRDVYEEDSYVKRSQGRIPVKW-MAIESLFDHI-YTTQSDVWSFGVLLWE 285 Query: 216 LLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIF 274 ++ G +PG + P+ S E R +Q P K Sbjct: 286 IVTLGGNPYPGIPPERLFNLLKTGHRMERPD---NCSEEMYRLMLQCWKQEPDKR----- 337 Query: 275 RGANPLAIDLLGRMLVL 291 ++ DL +M+V Sbjct: 338 PVFADISKDL-EKMMVK 353 >2W1I-A nrPDB Length = 326 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 68/319 (21%), Positives = 123/319 (38%), Gaps = 45/319 (14%) Query: 6 AGFYRQELNKTVWEV-------PQRLQGLRPVGSGAYGSVCSAY----DARLRQKVAVKK 54 Y Q + +E + L+ L+ +G G +GSV + VAVKK Sbjct: 18 ENLYFQGAMGSAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKK 77 Query: 55 LSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLN 114 L + H R RE+ +LK L+H+N++ V A + ++ L L Sbjct: 78 LQHSTEE--HLRDFEREIEILKSLQHDNIVKYKGVCYSAGR---RNLKLIMEYLPYGSLR 132 Query: 115 NIVKCQALSDEHVQFLVY--QLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLA 172 + ++ +H++ L Y Q+ +G++Y+ + IHRDL N+ V + ++I DFGL Sbjct: 133 DYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLT 192 Query: 173 RQADEEMTGY-------VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG 225 + ++ Y WY APE + ++ D+WS G ++ EL Sbjct: 193 KVLPQDKEYYKVKEPGESPIFWY-APESL-TESKFSVASDVWSFGVVLYELFT------- 243 Query: 226 SDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI--QSLPPMPQKDLSSIFRGANPLAID 283 +E +P E + I ++ I + + G Sbjct: 244 ---------YIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYM 294 Query: 284 LLGRMLVLDSDQRVSAAEA 302 ++ + +QR S + Sbjct: 295 IMTECWNNNVNQRPSFRDL 313 >3IO7-A nrPDB Length = 313 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 69/308 (22%), Positives = 123/308 (39%), Gaps = 39/308 (12%) Query: 10 RQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAY----DARLRQKVAVKKLSRPFQSLIHA 65 R N T +E + L+ L+ +G G +GSV + VAVKKL + H Sbjct: 17 RGSHNMTQFE-ERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE--HL 73 Query: 66 RRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDE 125 R RE+ +LK L+H+N++ V A + ++ L L + ++ + Sbjct: 74 RDFEREIEILKSLQHDNIVKYKGVCYSAGR---RNLKLIMEYLPYGSLRDYLQKHKERID 130 Query: 126 HVQFLVY--QLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY- 182 H++ L Y Q+ +G++Y+ + IHRDL N+ V + ++I DFGL + ++ Y Sbjct: 131 HIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYK 190 Query: 183 ------VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 WY APE + ++ D+WS G ++ EL + Sbjct: 191 VKEPGESPIFWY-APESL-TESKFSVASDVWSFGVVLYELFT----------------YI 232 Query: 237 EVVGTPSPEVLAKISSEHARTYI--QSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSD 294 E +P E + I ++ I + + G ++ + + Sbjct: 233 EKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVN 292 Query: 295 QRVSAAEA 302 QR S + Sbjct: 293 QRPSFRDL 300 >3OMV-A nrPDB Length = 307 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 56/274 (20%), Positives = 119/274 (43%), Gaps = 30/274 (10%) Query: 14 NKTVWEVPQRLQGLRP-VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYREL 72 + WE+ L +GSG++G+V + VAVK L + + E+ Sbjct: 27 SSYYWEIEASEVMLSTRIGSGSFGTVYKG---KWHGDVAVKILKVVDPTPEQFQAFRNEV 83 Query: 73 RLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQ--ALSDEHVQF 129 +L+ +H N++ + T + +VT G+ L + Q + Sbjct: 84 AVLRKTRHVNILLFMGYMTK-------DNLAIVTQWCEGSSLYKHLHVQETKFQMFQLID 136 Query: 130 LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR-----QADEEMTGYVA 184 + Q +G+ Y+H+ IIHRD+K +N+ ++E ++I DFGLA +++ Sbjct: 137 IARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTG 196 Query: 185 TRWYRAPEIM--LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRI------- 235 + + APE++ + ++ D++S G ++ EL+ G+ + + DQ+ + Sbjct: 197 SVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYAS 256 Query: 236 --MEVVGTPSPEVLAKISSEHARTYIQSLPPMPQ 267 + + P+ + ++ ++ + + P PQ Sbjct: 257 PDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQ 290 >3LLT-A nrPDB Length = 360 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 74/363 (20%), Positives = 142/363 (39%), Gaps = 65/363 (17%) Query: 2 SGPRAGFYRQELNKTV---WE----VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKK 54 S R Y Q ++ V W+ + +R +G G +G V ++ AVK Sbjct: 8 SSGRENLYFQGDDEIVHFSWKKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKV 67 Query: 55 LSRPFQSLIHARRTYRELRLLKHLKHENV-----IGLLDVFTPATSIEDFSEVYLVTTLM 109 + + + R E +LK ++++++ + F + + L+ + Sbjct: 68 VRNIKK---YTRSAKIEADILKKIQNDDINNNNIVKYHGKF------MYYDHMCLIFEPL 118 Query: 110 GADLNNIV---KCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNE------ 160 G L I+ E ++ ++L+ L Y+ + H DLKP N+ +++ Sbjct: 119 GPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKS 178 Query: 161 -------------------DCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYN 201 ++++DFG A + + TR YRAPE++LN + ++ Sbjct: 179 LITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKSDYHGSIINTRQYRAPEVILN-LGWD 237 Query: 202 QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQS 261 + D+WS GC++AEL G LF ++++ L + ++ +L + + + Y+ Sbjct: 238 VSSDMWSFGCVLAELYTGSLLFRTHEHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNK 297 Query: 262 -----LPPMPQKDLSSIFRGAN----------PLAIDLLGRMLVLDSDQRVSAAEALAHA 306 P ++SI L D L +L +D R S AE L H Sbjct: 298 DELKLAWPENASSINSIKHVKKCLPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHK 357 Query: 307 YFS 309 + Sbjct: 358 FLE 360 >4M7I-A nrPDB Length = 299 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 65/288 (22%), Positives = 127/288 (44%), Gaps = 33/288 (11%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 + ++ +G G +G V A + A+K++ P + L + RE++ L L+H Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELA-REKVMREVKALAKLEHPG 64 Query: 83 VIGLLDVFTPATSIEDFS------EVYLVTTLMG-ADLNNIVKCQALSDEHVQ----FLV 131 ++ + + + E +Y+ L +L + + + +E + + Sbjct: 65 IVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIF 124 Query: 132 YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE------------- 178 Q+ ++++HS G++HRDLKPSN+ D +++ DFGL D++ Sbjct: 125 LQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAY 184 Query: 179 --MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 TG V T+ Y +PE ++ Y+ VDI+S+G I+ ELL +P S +++++ + Sbjct: 185 ARHTGQVGTKLYMSPE-QIHGNSYSHKVDIFSLGLILFELL-----YPFSTQMERVRTLT 238 Query: 237 EVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDL 284 +V P + + L P P + +I N + DL Sbjct: 239 DVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDL 286 >4YHJ-A nrPDB Length = 584 Score = 191 bits (485), Expect = 5e-49, Method: Composition-based stats. Identities = 74/334 (22%), Positives = 128/334 (38%), Gaps = 54/334 (16%) Query: 10 RQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR-RT 68 RQ + K + + R +G G +G VC+ + A KKL + Sbjct: 179 RQPVTKNTF---RHY---RVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMA 232 Query: 69 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKC---QALSD 124 E R+L+ ++ V+ L A + E + LV T+M G DL + + Sbjct: 233 LNEKRILEKVQSRFVVSL------AYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDE 286 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE--EMTGY 182 + F +L GL+ + I++RDLKP N+ +++ +RI D GLA + E + G Sbjct: 287 QRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGR 346 Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTP 242 V T Y APE++ N Y + D W +GC++ E++QG + F + + + + + Sbjct: 347 VGTVGYMAPEVV-NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKND 405 Query: 243 SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV----- 297 + E K + A + +L + +R+ Sbjct: 406 TEEYSEKF---------------------------SEDAKSICRMLLTKNPSKRLGCRGE 438 Query: 298 SAAEALAHAYFSQYHDPEDEPE--AEPYDESVEA 329 AA H F + E P+ A Sbjct: 439 GAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHA 472 >5B2L-A nrPDB Length = 324 Score = 191 bits (485), Expect = 5e-49, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 112/299 (37%), Gaps = 42/299 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 L+ L +GSG G V + +AVK++ R + R +LK Sbjct: 17 NDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCP 76 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC--QALSDEHVQFLVYQLLRGLK 139 ++ F T +V++ LMG + K + + + + +++ L Sbjct: 77 YIVQCFGTFITNT------DVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALY 130 Query: 140 YI-HSAGIIHRDLKPSNVAVNEDCELRILDFGLA-RQADEEMTGY-VATRWYRAPEIML- 195 Y+ G+IHRD+KPSN+ ++E ++++ DFG++ R D + Y APE + Sbjct: 131 YLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDP 190 Query: 196 ---NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 Y+ D+WS+G + EL G+ + EVL K+ Sbjct: 191 PDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKT--------------DFEVLTKVLQ 236 Query: 253 EHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311 E L G + + L D +R + L H++ +Y Sbjct: 237 EE-------------PPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRY 282 >3SXS-A nrPDB Length = 268 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 55/267 (20%), Positives = 111/267 (41%), Gaps = 20/267 (7%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + + L+ +GSG +G V + VAVK + + + ++E + + L H Sbjct: 8 EEITLLKELGSGQFGVVKLGKWKG-QYDVAVKMIK---EGSMSEDEFFQEAQTMMKLSHP 63 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA--LSDEHVQFLVYQLLRGL 138 ++ V + I Y+VT + L N ++ L + + Y + G+ Sbjct: 64 KLVKFYGVCSKEYPI------YIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGM 117 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ-ADEEMTGYVATRW---YRAPEIM 194 ++ S IHRDL N V+ D +++ DFG+ R D++ V T++ + APE+ Sbjct: 118 AFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVF 177 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSE 253 ++ Y+ D+W+ G +M E+ GK + + + ++ + P + + + Sbjct: 178 -HYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQ 236 Query: 254 HARTYIQSLPPMPQKDLSSIFRGANPL 280 + LP + + PL Sbjct: 237 IMYSCWHELPE-KRPTFQQLLSSIEPL 262 >5U6B-A nrPDB Length = 307 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 56/295 (18%), Positives = 102/295 (34%), Gaps = 47/295 (15%) Query: 26 GLRPVGSGAYGSVCSAYDARLRQ--KVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 + +G G +G+V + KVAVK + + E +K H NV Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNV 86 Query: 84 IGLLDVFTPATSIEDFS-EVYLVTTLMGADLNNIVKCQALSDE-------HVQFLVYQLL 135 + L+ V + E F V ++ + DL++ + L D+ + + + Sbjct: 87 MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146 Query: 136 RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW-----YRA 190 G++Y+ + IHRDL N +NE+ + + DFGL+++ + A Sbjct: 147 SGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIA 206 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249 E + + + Y D+WS G M E+ G+ +PG + + + + P Sbjct: 207 IESLADRV-YTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPAD--- 262 Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 L+ R L+ R S E Sbjct: 263 ---------------------------CLDGLYALMSRCWELNPQDRPSFTELRE 290 >3KUL-B nrPDB Length = 325 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 61/277 (22%), Positives = 104/277 (37%), Gaps = 42/277 (15%) Query: 2 SGPRAGFYRQE--------LNKTVWEVP-------------QRLQGLRPVGSGAYGSVCS 40 S R Y Q +E P R+ + +GSG G VC Sbjct: 8 SSGRENLYFQGKLPEPQFYAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCY 67 Query: 41 AYDARLRQK---VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIE 97 Q+ VA+K L + R E ++ H N+I L V T Sbjct: 68 GRLRVPGQRDVPVAIKALKAGYTE-RQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLA- 125 Query: 98 DFSEVYLVTTLM-GADLNNIVKCQ--ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPS 154 +VT M L+ ++ + + ++ + G++Y+ G +HRDL Sbjct: 126 -----MIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAAR 180 Query: 155 NVAVNEDCELRILDFGLARQADEEMTGYVATRW------YRAPEIMLNWMHYNQTVDIWS 208 NV V+ + ++ DFGL+R +++ T + APE + + ++ D+WS Sbjct: 181 NVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIA-FRTFSSASDVWS 239 Query: 209 VGCIMAE-LLQGKALFPGSDYIDQLKRIMEVVGTPSP 244 G +M E L G+ + D + + E P+P Sbjct: 240 FGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAP 276 >3DLS-A nrPDB Length = 335 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 60/303 (19%), Positives = 125/303 (41%), Gaps = 54/303 (17%) Query: 19 EVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP------FQSLIHARRTYREL 72 E Q+ + P+GSGA+G V +A D ++V VK + + + + E+ Sbjct: 21 EYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEI 80 Query: 73 RLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLN---NIVKCQALSDEHVQF 129 +L ++H N+I +LD+F + LV G+ L+ I + L + + Sbjct: 81 AILSRVEHANIIKVLDIFENQGFFQ------LVMEKHGSGLDLFAFIDRHPRLDEPLASY 134 Query: 130 LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--DEEMTGYVATRW 187 + QL+ + Y+ IIHRD+K N+ + ED ++++DFG A + + T Sbjct: 135 IFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIE 194 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 247 Y APE+++ + +++WS+G + L+ + F + + ++ + S E++ Sbjct: 195 YCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPF--CELEETVEAAIHPPYLVSKELM 252 Query: 248 AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 307 + L+ +L ++R + + + + Sbjct: 253 S-----------------------------------LVSGLLQPVPERRTTLEKLVTDPW 277 Query: 308 FSQ 310 +Q Sbjct: 278 VTQ 280 >3QUP-A nrPDB Length = 323 Score = 188 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 58/301 (19%), Positives = 103/301 (34%), Gaps = 48/301 (15%) Query: 15 KTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQ---KVAVKKLSRPFQSLIHARRTYRE 71 + V Q+ R +G G +GSV A + KVAVK L + RE Sbjct: 16 EDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLRE 75 Query: 72 LRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSD------ 124 +K H +V L+ V + + ++ M DL+ + + + Sbjct: 76 AACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLP 135 Query: 125 -EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYV 183 + + + + G++Y+ S IHRDL N + ED + + DFGL+R+ Sbjct: 136 LQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQ 195 Query: 184 ATRW-----YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIME 237 + A E + + + Y D+W+ G M E++ G+ + G + + ++ Sbjct: 196 GCASKLPVKWLALESLADNL-YTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIG 254 Query: 238 VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV 297 P DL+ + D QR Sbjct: 255 GNRLKQP------------------------------PECMEEVYDLMYQCWSADPKQRP 284 Query: 298 S 298 S Sbjct: 285 S 285 >1FVR-A nrPDB Length = 327 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 62/307 (20%), Positives = 111/307 (36%), Gaps = 64/307 (20%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKV--AVKKLSRPFQSLIHARRTYRELRLLKHL- 78 ++ +G G +G V A + ++ A+K++ + + S R EL +L L Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRM-KEYASKDDHRDFAGELEVLCKLG 83 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA---------------- 121 H N+I LL E +YL +L + ++ Sbjct: 84 HHPNIINLLGAC------EHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTAS 137 Query: 122 -LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ---ADE 177 LS + + + RG+ Y+ IHRDL N+ V E+ +I DFGL+R + Sbjct: 138 TLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVK 197 Query: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIM 236 + G + RW A E + N+ Y D+WS G ++ E++ G + G + +++ Sbjct: 198 KTMGRLPVRW-MAIESL-NYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLP 255 Query: 237 EVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQR 296 + P + DL+ + +R Sbjct: 256 QGYRLEKP------------------------------LNCDDEVYDLMRQCWREKPYER 285 Query: 297 VSAAEAL 303 S A+ L Sbjct: 286 PSFAQIL 292 >6DBN-A nrPDB Length = 316 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 63/300 (21%), Positives = 115/300 (38%), Gaps = 35/300 (11%) Query: 12 ELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDA----RLRQKVAVKKLSRPFQSLIHARR 67 E++ T +E + L+ +R +G G +G V ++VAVK L +P H Sbjct: 26 EVDPTHFE-KRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSL-KPESGGNHIAD 83 Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV--KCQALSDE 125 +E+ +L++L HEN++ + T ++ L L + ++ + Sbjct: 84 LKKEIEILRNLYHENIVKYKGICTEDGGNGIK---LIMEFLPSGSLKEYLPKNKNKINLK 140 Query: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYV-- 183 Q+ +G+ Y+ S +HRDL NV V + +++I DFGL + + + Y Sbjct: 141 QQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVK 200 Query: 184 -----ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 238 WY APE ++ Y D+WS G + ELL + +++ Sbjct: 201 DDRDSPVFWY-APECLMQSKFY-IASDVWSFGVTLHELLT-----YCDSDSSPMALFLKM 253 Query: 239 VGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS 298 +G P+ + + + LP P L+ + R S Sbjct: 254 IG-PTHGQMTVTRLVNTLKEGKRLPCPP---------NCPDEVYQLMRKCWEFQPSNRTS 303 >5O0Y-A nrPDB Length = 579 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 119/298 (39%), Gaps = 53/298 (17%) Query: 35 YGSVCSAYDARLRQKVAVKK--LSRPFQSLIHA---RRTYRELRLLKHLKHENVIGLLDV 89 + V A+D ++ VAVK L++ ++ + RE R+ K L H ++ L D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 90 FTPATSIEDFSEVYLVTTLMGADLNNIVKCQAL-SDEHVQFLVYQLLRGLKYIHSAG--I 146 F S++ S ++ G DL+ +K L S++ + ++ Q++ LKY++ I Sbjct: 357 F----SLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPI 412 Query: 147 IHRDLKPSNVAVNED---CELRILDFGLARQADEEMTGYV----------ATRWYRAPEI 193 IH DLKP N+ + E++I DFGL++ D++ V T WY PE Sbjct: 413 IHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPEC 472 Query: 194 MLNWM---HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI 250 + + VD+WSVG I + L G+ F G + Q I Sbjct: 473 FVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQQ-----------------DI 514 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 E+ + P+ P A + R L + R+ + Y Sbjct: 515 LQENTILKATEVQFPPK-------PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 565 >1LUF-A nrPDB Length = 343 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 68/309 (22%), Positives = 110/309 (35%), Gaps = 57/309 (18%) Query: 19 EVPQR-LQGLRPVGSGAYGSVCSAYDARL-----RQKVAVKKLSRPFQSLIHARRTYREL 72 E P+ ++ +R +G GA+G V A L VAVK L + + A RE Sbjct: 43 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQA-DFQREA 101 Query: 73 RLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKC------------ 119 L+ + N++ LL V + L+ M DLN ++ Sbjct: 102 ALMAEFDNPNIVKLLGVCAVGKP------MCLLFEYMAYGDLNEFLRSMSPHTVCSLSHS 155 Query: 120 -------------QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRI 166 LS + Q+ G+ Y+ +HRDL N V E+ ++I Sbjct: 156 DLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKI 215 Query: 167 LDFGLARQADE------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-G 219 DFGL+R + + RW PE + + Y D+W+ G ++ E+ G Sbjct: 216 ADFGLSRNIYSADYYKADGNDAIPIRW-MPPESIF-YNRYTTESDVWAYGVVLWEIFSYG 273 Query: 220 KALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANP 279 + G + + + + + PE R LP + SI R Sbjct: 274 LQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPA-DRPSFCSIHR---- 328 Query: 280 LAIDLLGRM 288 +L RM Sbjct: 329 ----ILQRM 333 >4PDO-A nrPDB Length = 299 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 50/238 (21%), Positives = 100/238 (42%), Gaps = 22/238 (9%) Query: 21 PQRLQGLRPVGSGAYGSVCSAYDARLRQK----VAVKKLSRPFQSLIHARRTYRELRLLK 76 P + + +G+G +G V K VA+K L + E ++ Sbjct: 33 PSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRV-DFLGEAGIMG 91 Query: 77 HLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQ--ALSDEHVQFLVYQ 133 H N+I L V + + + ++T M L+ ++ + S + ++ Sbjct: 92 QFSHHNIIRLEGVISK------YKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRG 145 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW------ 187 + G+KY+ + +HRDL N+ VN + ++ DFGL+R +++ T Sbjct: 146 IAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIR 205 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSP 244 + APE + ++ + D+WS G +M E++ G+ + + +K I + P+P Sbjct: 206 WTAPEAI-SYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTP 262 >4HZS-A nrPDB Length = 341 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 63/243 (25%), Positives = 98/243 (40%), Gaps = 23/243 (9%) Query: 22 QRLQGLRPVGSGAYGSVCSA-YDARLRQKV--AVKKLSRPFQSLIHA-RRTYRELRLLKH 77 + L+ L +G G++G V +DA + V AVK L S A RE+ + Sbjct: 12 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 71 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTL--MGADLNNIVKCQA-LSDEHVQFLVYQL 134 L H N+I L V +VT L +G+ L+ + K Q + Q+ Sbjct: 72 LDHRNLIRLYGVVLTPPMK-------MVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQV 124 Query: 135 LRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW------Y 188 G+ Y+ S IHRDL N+ + ++I DFGL R + YV + Sbjct: 125 AEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAW 184 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRI-MEVVGTPSPEV 246 APE + ++ D W G + E+ G+ + G + L +I E P PE Sbjct: 185 CAPESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPED 243 Query: 247 LAK 249 + Sbjct: 244 CPQ 246 >3BBT-B nrPDB Length = 328 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 67/306 (21%), Positives = 118/306 (38%), Gaps = 24/306 (7%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKV----AVKKLSRPFQSLIHARRTYRELRLLKHLK 79 L+ ++ +GSGA+G+V + V A+K L+ + E ++ + Sbjct: 17 LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVE-FMDEALIMASMD 75 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA--LSDEHVQFLVYQLLR 136 H +++ LL V T + LVT LM L V + + + Q+ + Sbjct: 76 HPHLVRLLGVCLSPT-------IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAK 128 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW-----YRAP 191 G+ Y+ ++HRDL NV V ++I DFGLAR + + Y A + A Sbjct: 129 GMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMAL 188 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI 250 E + ++ + D+WS G + EL+ G + G + + + P P + I Sbjct: 189 ECI-HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICT-I 246 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + + + + +A D R LV+ D R+ +F Sbjct: 247 DVYMVMVKCWMIDADSRPKFKELAAEFSRMARD-PQRYLVIQGDDRMKLPSPNDSKFFQN 305 Query: 311 YHDPED 316 D ED Sbjct: 306 LLDEED 311 >4YFF-A nrPDB Length = 311 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 58/259 (22%), Positives = 106/259 (40%), Gaps = 22/259 (8%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLS-RPFQSLIHARRTYRELRLLKHLKHEN 82 ++ +GSG++G V + VA+K+ + S RE+ +L L H Sbjct: 44 IEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPC 101 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA--LSDEHVQFLVYQLLRGLK 139 VI + + D S+ +VT + G L +++ Q L + + + +G++ Sbjct: 102 VIQFVGAC-----LNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGME 156 Query: 140 YIHS--AGIIHRDLKPSNVAVNEDCELRILDFGLARQA----DEEMTGYVATRWYRAPEI 193 Y+H+ IIHRDL N+ + ED + DFG +R ++ MT + APE+ Sbjct: 157 YLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEV 216 Query: 194 MLNWMHYNQTVDIWSVGCIMAELLQGKALF----PGSDYID-QLKRIMEVVGTPSPEVLA 248 Y D++S + E+L G+ F P + D I +G P+ ++ Sbjct: 217 FTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPIS 276 Query: 249 KISSEHARTYIQSLPPMPQ 267 + + P + Sbjct: 277 SLLIRGWNACPEGRPEFSE 295 >5HLW-A nrPDB Length = 299 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 58/250 (23%), Positives = 106/250 (42%), Gaps = 27/250 (10%) Query: 28 RPVGSGAYGSVCSAYDARLRQK---VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVI 84 +G G +G V K AVK L+R + + E ++K H NV+ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDFSHPNVL 84 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSD--EHVQFLVYQLLRGLKYIH 142 LL + + + S + ++ + DL N ++ + + + + Q+ +G+KY+ Sbjct: 85 SLLGICLRS----EGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLA 140 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW-------YRAPEIML 195 S +HRDL N ++E +++ DFGLAR ++ V + + A E + Sbjct: 141 SKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQ 200 Query: 196 NWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYID------QLKRIMEVVGTPSP--EV 246 + D+WS G ++ EL+ G +P + D Q +R+++ P P EV Sbjct: 201 T-QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEV 259 Query: 247 LAKISSEHAR 256 + K A Sbjct: 260 MLKCWHPKAE 269 >4LFI-A nrPDB Length = 374 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 77/336 (22%), Positives = 146/336 (43%), Gaps = 49/336 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAV------------------------KKLSR 57 + + VG G Y V + K+ + K Sbjct: 40 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 99 Query: 58 PFQSLIHARRTYRELRLLKHLK----------HENVIGLLDVFTPATSIEDFSEVYLVTT 107 T ++ +LK ++ H N+I L D+ S LV Sbjct: 100 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA----LVFE 155 Query: 108 LMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRI 166 + +++ + L+D ++F +++LL+ L Y HS GI+HRD+KP NV ++ ++ +LR+ Sbjct: 156 YVD-NVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRL 214 Query: 167 LDFGLAR--QADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAEL-LQGKALF 223 +D+GLA + E VA+R+++ PE+++++ Y+ ++D+WS G ++A + + + F Sbjct: 215 IDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF 274 Query: 224 PGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFR------GA 277 G+ DQL +I++V+GT E + +K Sbjct: 275 HGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSG 334 Query: 278 NPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHD 313 N IDL+ +L D +R++A EA+ H +F+ + Sbjct: 335 NDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 370 >3ZBF-A nrPDB Length = 322 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 67/321 (20%), Positives = 111/321 (34%), Gaps = 67/321 (20%) Query: 6 AGFYRQELNKTVWEVP-QRLQGLRPVGSGAYGSVCSAYDARL------RQKVAVKKLSRP 58 Y Q + + P ++L +GSGA+G V + KVAVK L + Sbjct: 16 ENLYFQGSIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKG 75 Query: 59 FQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV 117 +E L+ H N++ L V Y++ LM G DL + Sbjct: 76 STDQEKIE-FLKEAHLMSKFNHPNILKQLGVCLLNEPQ------YIILELMEGGDLLTYL 128 Query: 118 KCQAL--------SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE-----L 164 + + + + L + +G Y+ IHRDL N V+ + Sbjct: 129 RKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIV 188 Query: 165 RILDFGLARQADEEMT------GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ 218 +I DFGLAR + G + RW APE +++ + + D+WS G ++ E+L Sbjct: 189 KIGDFGLARDIYKNDYYRKRGEGLLPVRW-MAPESLMDGI-FTTQSDVWSFGILIWEILT 246 Query: 219 -GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGA 277 G +P +D L + P R Sbjct: 247 LGHQPYPAHSNLDVLNYVQTGGRLEPP------------------------------RNC 276 Query: 278 NPLAIDLLGRMLVLDSDQRVS 298 +L+ + + DQR + Sbjct: 277 PDDLWNLMTQCWAQEPDQRPT 297 >4H1J-A nrPDB Length = 293 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 55/280 (19%), Positives = 104/280 (37%), Gaps = 48/280 (17%) Query: 28 RPVGSGAYGSVCSAY---DARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVI 84 R +G G +G V + VAVK + L + + E ++K+L H +++ Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCT-LDNKEKFMSEAVIMKNLDHPHIV 88 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA--LSDEHVQFLVYQLLRGLKYIH 142 L+ + IE+ ++ +L + ++ L + Q+ + + Y+ Sbjct: 89 KLIGI------IEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLE 142 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVATRW---YRAPEIMLNWM 198 S +HRD+ N+ V +++ DFGL+R DE+ TR + +PE + N+ Sbjct: 143 SINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESI-NFR 201 Query: 199 HYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257 + D+W M E+L GK F + D + + + P P++ Sbjct: 202 RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDL----------- 250 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV 297 P+ L+ R D R Sbjct: 251 -------------------CPPVLYTLMTRCWDYDPSDRP 271 >5TUR-A nrPDB Length = 404 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 66/311 (21%), Positives = 121/311 (38%), Gaps = 54/311 (17%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP----FQSLIHARRTYRELRLL 75 + + Q +GSG +GSV S VA+K + + + L + R E+ LL Sbjct: 125 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 184 Query: 76 KHLKH--ENVIGLLDVFTPATSIEDFSEVYLVTTLMGA--DLNNIV-KCQALSDEHVQFL 130 K + VI LLD F S L+ DL + + + AL +E + Sbjct: 185 KKVSSGFSGVIRLLDWFERPDS------FVLILERPEPVQDLFDFITERGALQEELARSF 238 Query: 131 VYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGL-ARQADEEMTGYVATRWY 188 +Q+L +++ H+ G++HRD+K N+ ++ EL+++DFG A D T + TR Y Sbjct: 239 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVY 298 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLA 248 PE + ++ ++ +WS+G ++ +++ G F + I + + Sbjct: 299 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR----------- 347 Query: 249 KISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 + + L+ L L R + E H + Sbjct: 348 --------------------------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 381 Query: 309 SQYHDPEDEPE 319 P++ E Sbjct: 382 QDVLLPQETAE 392 >3BGP-A nrPDB Length = 333 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 66/311 (21%), Positives = 121/311 (38%), Gaps = 54/311 (17%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP----FQSLIHARRTYRELRLL 75 + + Q +GSG +GSV S VA+K + + + L + R E+ LL Sbjct: 54 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 113 Query: 76 KHLKH--ENVIGLLDVFTPATSIEDFSEVYLVTTLMGA--DLNNIV-KCQALSDEHVQFL 130 K + VI LLD F S L+ DL + + + AL +E + Sbjct: 114 KKVSSGFSGVIRLLDWFERPDS------FVLILERPEPVQDLFDFITERGALQEELARSF 167 Query: 131 VYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGL-ARQADEEMTGYVATRWY 188 +Q+L +++ H+ G++HRD+K N+ ++ EL+++DFG A D T + TR Y Sbjct: 168 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVY 227 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLA 248 PE + ++ ++ +WS+G ++ +++ G F + I + + Sbjct: 228 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR----------- 276 Query: 249 KISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 + + L+ L L R + E H + Sbjct: 277 --------------------------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 310 Query: 309 SQYHDPEDEPE 319 P++ E Sbjct: 311 QDVLLPQETAE 321 >5U6C-A nrPDB Length = 315 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 54/284 (19%), Positives = 101/284 (35%), Gaps = 31/284 (10%) Query: 6 AGFYRQELNKTVWEVPQRLQ----------GLRPVGSGAYGSVCSA---YDARLRQKVAV 52 Y Q E+ +L+ + +G G +GSV + KVAV Sbjct: 14 ENLYFQGSE----ELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAV 69 Query: 53 KKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGAD 112 K + S E +K H NV+ LL V +S + ++ + D Sbjct: 70 KTMKLDNSSQREIEEFLSEAACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGD 129 Query: 113 LNNIVKCQAL-------SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELR 165 L+ + L + + + + G++Y+ + +HRDL N + +D + Sbjct: 130 LHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVC 189 Query: 166 ILDFGLARQADEEMTGYVATRW-----YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-G 219 + DFGL+++ + A E + + + Y D+W+ G M E+ G Sbjct: 190 VADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRV-YTSKSDVWAFGVTMWEIATRG 248 Query: 220 KALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLP 263 +PG + ++ PE E + ++ P Sbjct: 249 MTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDP 292 >4X7Q-B nrPDB Length = 312 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 68/320 (21%), Positives = 123/320 (38%), Gaps = 56/320 (17%) Query: 14 NKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP----FQSLIHARRTY 69 ++ +E RL L +G G +G+V + + R +VA+K + R + L + Sbjct: 25 DREAFEAEYRLGPL--LGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCP 82 Query: 70 RELRLLKHLK----HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV-KCQALSD 124 E+ LL + H VI LLD F ++ + L L DL + + + L + Sbjct: 83 LEVALLWKVGAGGGHPGVIRLLDWFET----QEGFMLVLERPLPAQDLFDYITEKGPLGE 138 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGL-ARQADEEMTGY 182 + Q++ +++ HS G++HRD+K N+ ++ +++DFG A DE T + Sbjct: 139 GPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDF 198 Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTP 242 TR Y PE + ++ +WS+G ++ +++ G F Sbjct: 199 DGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPF------------------- 239 Query: 243 SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEA 302 E + +++ P +P L+ R L R S E Sbjct: 240 ----------ERDQEILEAELHFPA--------HVSPDCCALIRRCLAPKPSSRPSLEEI 281 Query: 303 LAHAYFSQYHDPEDEPEAEP 322 L + ED P Sbjct: 282 LLDPWMQT--PAEDVPLNPS 299 >3C1X-A nrPDB Length = 373 Score = 185 bits (469), Expect = 4e-47, Method: Composition-based stats. Identities = 57/251 (22%), Positives = 105/251 (41%), Gaps = 29/251 (11%) Query: 28 RPVGSGAYGSVCSAYDARLRQK---VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVI 84 +G G +G V K AVK L+R + + E ++K H NV+ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDFSHPNVL 153 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSD--EHVQFLVYQLLRGLKYIH 142 LL + + + S + ++ + DL N ++ + + + + Q+ +G+K++ Sbjct: 154 SLLGICLRS----EGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLA 209 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--------DEEMTGYVATRWYRAPEIM 194 S +HRDL N ++E +++ DFGLAR + + +W A E + Sbjct: 210 SKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKW-MALESL 268 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYID------QLKRIMEVVGTPSP--E 245 + D+WS G ++ EL+ G +P + D Q +R+++ P P E Sbjct: 269 QT-QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYE 327 Query: 246 VLAKISSEHAR 256 V+ K A Sbjct: 328 VMLKCWHPKAE 338 >1U54-B nrPDB Length = 291 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 63/243 (25%), Positives = 98/243 (40%), Gaps = 23/243 (9%) Query: 22 QRLQGLRPVGSGAYGSVCSA-YDARLRQKV--AVKKLSRPFQSLIHA-RRTYRELRLLKH 77 + L+ L +G G++G V +DA + V AVK L S A RE+ + Sbjct: 18 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 77 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTL--MGADLNNIVKCQA-LSDEHVQFLVYQL 134 L H N+I L V +VT L +G+ L+ + K Q + Q+ Sbjct: 78 LDHRNLIRLYGVVLTPPMK-------MVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQV 130 Query: 135 LRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW------Y 188 G+ Y+ S IHRDL N+ + ++I DFGL R + YV + Sbjct: 131 AEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAW 190 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRI-MEVVGTPSPEV 246 APE + ++ D W G + E+ G+ + G + L +I E P PE Sbjct: 191 CAPESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPED 249 Query: 247 LAK 249 + Sbjct: 250 CPQ 252 >6B2Q-A nrPDB Length = 317 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 67/211 (31%), Positives = 102/211 (48%), Gaps = 9/211 (4%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH-ARRTYRELRLLKHLKHE 81 R + R + +G G V A D RL ++VAVK L F S R E R L H Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 92 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGAD-LNNIVKC-QALSDEHVQFLVYQLLRGLK 139 + + D + + + YLV L+ + LN+++K LS H ++ Q R L+ Sbjct: 93 GIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 151 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE---EMTGYV-ATRWYRAPEIML 195 H+AG++HRD+KP N+ + +++I DFG+A+ D TG V T Y APE L Sbjct: 152 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 211 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGS 226 + D++S+G + E + GK F G Sbjct: 212 GHDA-SPASDVYSLGVVGYEAVSGKRPFAGD 241 >4X3F-A nrPDB Length = 337 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 67/211 (31%), Positives = 102/211 (48%), Gaps = 9/211 (4%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH-ARRTYRELRLLKHLKHE 81 R + R + +G G V A D RL ++VAVK L F S R E R L H Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 72 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGAD-LNNIVKC-QALSDEHVQFLVYQLLRGLK 139 + + D + + + YLV L+ + LN+++K LS H ++ Q R L+ Sbjct: 73 GIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 131 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE---EMTGYV-ATRWYRAPEIML 195 H+AG++HRD+KP N+ + +++I DFG+A+ D TG V T Y APE L Sbjct: 132 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 191 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGS 226 + D++S+G + E + GK F G Sbjct: 192 GHDA-SPASDVYSLGVVGYEAVSGKRPFAGD 221 >4OW8-A nrPDB Length = 283 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 67/211 (31%), Positives = 102/211 (48%), Gaps = 9/211 (4%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH-ARRTYRELRLLKHLKHE 81 R + R + +G G V A D RL ++VAVK L F S R E R L H Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 71 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGAD-LNNIVKC-QALSDEHVQFLVYQLLRGLK 139 + + D + + + YLV L+ + LN+++K LS H ++ Q R L+ Sbjct: 72 GIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 130 Query: 140 YIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE---EMTGYV-ATRWYRAPEIML 195 H+AG++HRD+KP N+ + +++I DFG+A+ D TG V T Y APE L Sbjct: 131 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 190 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGS 226 + D++S+G + E + GK F G Sbjct: 191 GHDA-SPASDVYSLGVVGYEAVSGKRPFAGD 220 >4HVI-A nrPDB Length = 314 Score = 183 bits (466), Expect = 7e-47, Method: Composition-based stats. Identities = 65/300 (21%), Positives = 115/300 (38%), Gaps = 40/300 (13%) Query: 14 NKTVWEVPQRLQGLRPVGSGAYGSVCSA-YDA---RLRQKVAVKKLSRPFQSLIHARRTY 69 + T++E + L+ + +G G +GSV YD VAVK+L R Sbjct: 3 DPTIFE-ERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHS--GPDQQRDFQ 59 Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA--LSDEH 126 RE+++LK L + ++ V + LV + L + ++ L Sbjct: 60 REIQILKALHSDFIVKYRGVSYGPG----RQSLRLVMEYLPSGCLRDFLQRHRARLDASR 115 Query: 127 VQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYV--- 183 + Q+ +G++Y+ S +HRDL N+ V + ++I DFGLA+ + YV Sbjct: 116 LLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVRE 175 Query: 184 ----ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVV 239 WY APE + + + +++ D+WS G ++ EL + Sbjct: 176 PGQSPIFWY-APESLSDNI-FSRQSDVWSFGVVLYELFT----------------YCDKS 217 Query: 240 GTPSPEVLAKISSEH-ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS 298 +PS E L + SE + L + + +L+ R S Sbjct: 218 CSPSAEFLRMMGSERDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPS 277 >5VD3-A nrPDB Length = 311 Score = 183 bits (466), Expect = 8e-47, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 110/296 (37%), Gaps = 45/296 (15%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL- 78 Q Q L +G G+YG V + AVK+ PF+ R E+ + + Sbjct: 55 FQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVG 114 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA--LSDEHVQFLVYQLLR 136 +H + L + E+ +YL T L G L + L + V + L Sbjct: 115 QHPCCVRL------EQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLL 168 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYV--ATRWYRAPEIM 194 L ++HS G++H D+KP+N+ + ++ DFGL + G V Y APE++ Sbjct: 169 ALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELL 228 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH 254 Y D++S+G + E+ L G + QL++ G PE A +SSE Sbjct: 229 QG--SYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQ-----GYLPPEFTAGLSSEL 281 Query: 255 ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 + ML D R +A LA Q Sbjct: 282 RSVLVM---------------------------MLEPDPKLRATAEALLALPVLRQ 310 >2WTK-B nrPDB Length = 373 Score = 183 bits (465), Expect = 9e-47, Method: Composition-based stats. Identities = 63/331 (19%), Positives = 126/331 (38%), Gaps = 40/331 (12%) Query: 24 LQGLRPVGSGAYG---SVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKH 80 + L +G G + +V A + V V++++ S EL + K H Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNH 69 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQ---ALSDEHVQFLVYQLLR 136 N++ F +E+++VT+ M +++ +++ + +++ +L+ Sbjct: 70 PNIVPYRATFIA------DNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLK 123 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRI---------LDFGLARQADEEMTGY-VATR 186 L YIH G +HR +K S++ ++ D ++ + + G ++ + Y V Sbjct: 124 ALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVL 183 Query: 187 WYRAPEIM-LNWMHYNQTVDIWSVGCIMAELLQGKALFPG--------SDYIDQLKRIME 237 + +PE++ N Y+ DI+SVG EL G F + +++ Sbjct: 184 PWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLD 243 Query: 238 VVGTPSPEVLAKISSEHARTYI-------QSLPPMPQKDLSSIFRGANPLAIDLLGRMLV 290 P+ E+ S A + + P R +P + + L Sbjct: 244 TSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQ 303 Query: 291 LDSDQRVSAAEALAHAYFSQYHDPEDEPEAE 321 + D R SA+ L H++F Q E E Sbjct: 304 RNPDARPSASTLLNHSFFKQIKRRASEALPE 334 >4RC3-A nrPDB Length = 289 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 66/311 (21%), Positives = 121/311 (38%), Gaps = 54/311 (17%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP----FQSLIHARRTYRELRLL 75 + + Q +GSG +GSV S VA+K + + + L + R E+ LL Sbjct: 10 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 69 Query: 76 KHLKH--ENVIGLLDVFTPATSIEDFSEVYLVTTLMGA--DLNNIV-KCQALSDEHVQFL 130 K + VI LLD F S L+ DL + + + AL +E + Sbjct: 70 KKVSSGFSGVIRLLDWFERPDS------FVLILERPEPVQDLFDFITERGALQEELARSF 123 Query: 131 VYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGL-ARQADEEMTGYVATRWY 188 +Q+L +++ H+ G++HRD+K N+ ++ EL+++DFG A D T + TR Y Sbjct: 124 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVY 183 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLA 248 PE + ++ ++ +WS+G ++ +++ G F + I + + Sbjct: 184 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR----------- 232 Query: 249 KISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 + + L+ L L R + E H + Sbjct: 233 --------------------------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 266 Query: 309 SQYHDPEDEPE 319 P++ E Sbjct: 267 QDVLLPQETAE 277 >6FEX-A nrPDB Length = 321 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 66/330 (20%), Positives = 119/330 (36%), Gaps = 70/330 (21%) Query: 19 EVPQ-RLQGLRPVGSGAYGSVCSAY--------------DARLRQK--VAVKKLSRPFQS 61 + P+ RL+ +G G +G V + R VAVK L RP + Sbjct: 12 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL-RPDAT 70 Query: 62 LIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA 121 +E++++ LK N+I LL V ++D + + DLN + Sbjct: 71 KNARNDFLKEVKIMSRLKDPNIIRLLGVC-----VQDDPLCMITDYMENGDLNQFLSAHQ 125 Query: 122 LSD--------------EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRIL 167 L D + + Q+ G++Y+ + +HRDL N V E+ ++I Sbjct: 126 LEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIA 185 Query: 168 DFGLARQADEEMTGYVATR-----WYRAPEIMLNWMHYNQTVDIWSVGCIMAE--LLQGK 220 DFG++R V R + A E +L + D+W+ G + E +L Sbjct: 186 DFGMSRNLYAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCRA 244 Query: 221 ALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPL 280 F G + E + + + E R + + S Sbjct: 245 QPF----------------GQLTDEQVIENAGEFFRDQGRQVY-------LSRPPACPQG 281 Query: 281 AIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 +L+ R +S+QR ++ H + ++ Sbjct: 282 LYELMLRCWSRESEQRPPFSQL--HRFLAE 309 >3M42-A nrPDB Length = 299 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 61/320 (19%), Positives = 120/320 (37%), Gaps = 62/320 (19%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLL-KHLKHENVIGL 86 + +G G G V ++ R ++K A+K L + RE+ L + + +++ + Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCPHIVRI 76 Query: 87 LDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQA---LSDEHVQFLVYQLLRGLKYIH 142 +DV+ + + +V + G +L + ++ + ++ ++ + ++Y+H Sbjct: 77 VDVYENLYA--GRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 143 SAGIIHRDLKPSNVAVNE---DCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMH 199 S I HRD+KP N+ + L++ DFG A++ E Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGE--------------------K 174 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI 259 Y+++ D+WS+G IM LL G F + + IS Sbjct: 175 YDKSCDMWSLGVIMYILLCGYPPFYSNHGL-------------------AISPGMKTRIR 215 Query: 260 QSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEP- 318 P + S + + L+ +L + QR++ E + H + Q P Sbjct: 216 MGQYEFPNPEWSEV----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPL 271 Query: 319 -EAEPYDESVEAKERTLEEW 337 + E E E EE Sbjct: 272 HTSRVLKEDKERWEDVKEEM 291 >1U59-A nrPDB Length = 287 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 53/229 (23%), Positives = 98/229 (42%), Gaps = 23/229 (10%) Query: 29 PVGSGAYGSVCSAYDARLRQK--VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 86 +G G +GSV +++ VA+K L + + RE +++ L + ++ L Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK-ADTEEMMREAQIMHQLDNPYIVRL 75 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGA-DLNNIV--KCQALSDEHVQFLVYQLLRGLKYIHS 143 + V + LV + G L+ + K + + +V L++Q+ G+KY+ Sbjct: 76 IGVCQAEA-------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 128 Query: 144 AGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY-------VATRWYRAPEIMLN 196 +HRDL NV + +I DFGL++ + + Y +WY APE + N Sbjct: 129 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECI-N 186 Query: 197 WMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSP 244 + ++ D+WS G M E L G+ + + + I + P Sbjct: 187 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP 235 >3I81-A nrPDB Length = 315 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 53/310 (17%), Positives = 110/310 (35%), Gaps = 60/310 (19%) Query: 16 TVWEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQ-----KVAVKKLSRPFQSLIHARRTY 69 WEV +++ R +G G++G V + + +VA+K ++ S+ Sbjct: 11 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAA-SMRERIEFL 69 Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC---------- 119 E ++K +V+ LL V + + ++ + DL + ++ Sbjct: 70 NEASVMKEFNCHHVVRLLGVVSQGQP-----TLVIMELMTRGDLKSYLRSLRPEMENNPV 124 Query: 120 -QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE 178 S + + ++ G+ Y+++ +HRDL N V ED ++I DFG+ R E Sbjct: 125 LAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYET 184 Query: 179 MTGYVATRW-----YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQL 232 + + +PE + + + + D+WS G ++ E+ + + G L Sbjct: 185 DYYRKGGKGLLPVRWMSPESLKDGV-FTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVL 243 Query: 233 KRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLD 292 + +ME P+ + +L+ + Sbjct: 244 RFVMEGGLLDKPD------------------------------NCPDMLFELMRMCWQYN 273 Query: 293 SDQRVSAAEA 302 R S E Sbjct: 274 PKMRPSFLEI 283 >3PLS-A nrPDB Length = 298 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 58/285 (20%), Positives = 103/285 (36%), Gaps = 51/285 (17%) Query: 28 RPVGSGAYGSVCSAY---DARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVI 84 R +G G +G V A+ R + A+K LSR + RE L++ L H NV+ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSR-ITEMQQVEAFLREGLLMRGLNHPNVL 85 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSD--EHVQFLVYQLLRGLKYIH 142 L+ + P + L+ + DL ++ + + + Q+ RG++Y+ Sbjct: 86 ALIGIMLPPEGLPH----VLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLA 141 Query: 143 SAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--------DEEMTGYVATRWYRAPEIM 194 +HRDL N ++E +++ DFGLAR + + +W A E + Sbjct: 142 EQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKW-TALESL 200 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSE 253 + + D+WS G ++ ELL G + D D + + P PE Sbjct: 201 QTYR-FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEY------- 252 Query: 254 HARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS 298 ++ + D R + Sbjct: 253 -----------------------CPDSLYQVMQQCWEADPAVRPT 274 >6BSD-A nrPDB Length = 876 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 66/336 (19%), Positives = 119/336 (35%), Gaps = 76/336 (22%) Query: 19 EVPQ-RLQGLRPVGSGAYGSVCSAY--------------DARLRQK--VAVKKLSRPFQS 61 + P+ RL+ +G G +G V + R VAVK L RP + Sbjct: 567 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL-RPDAT 625 Query: 62 LIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA 121 +E++++ LK N+I LL V ++D + + DLN + Sbjct: 626 KNARNDFLKEVKIMSRLKDPNIIRLLGVC-----VQDDPLCMITDYMENGDLNQFLSAHQ 680 Query: 122 LSD--------------------EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED 161 L D + + Q+ G++Y+ + +HRDL N V E+ Sbjct: 681 LEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGEN 740 Query: 162 CELRILDFGLARQADEEMTGYVATR-----WYRAPEIMLNWMHYNQTVDIWSVGCIMAE- 215 ++I DFG++R V R + A E +L + D+W+ G + E Sbjct: 741 FTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEV 799 Query: 216 -LLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIF 274 +L F G + E + + + E R + + S Sbjct: 800 LMLCRAQPF----------------GQLTDEQVIENAGEFFRDQGRQVY-------LSRP 836 Query: 275 RGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310 +L+ R +S+QR ++ H + ++ Sbjct: 837 PACPQGLYELMLRCWSRESEQRPPFSQL--HRFLAE 870 >5UIU-A nrPDB Length = 323 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 57/230 (24%), Positives = 97/230 (42%), Gaps = 24/230 (10%) Query: 6 AGFYRQELNKTVWEVPQRLQGLR--PVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLI 63 F EL +R + +G G +G V Y VAVKKL+ Sbjct: 29 HSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITT 86 Query: 64 HA--RRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKC- 119 ++ +E++++ +HEN++ LL + D ++ LV M L + + C Sbjct: 87 EELKQQFDQEIKVMAKCQHENLVELLGFSS------DGDDLCLVYVYMPNGSLLDRLSCL 140 Query: 120 ---QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD 176 LS + G+ ++H IHRD+K +N+ ++E +I DFGLAR ++ Sbjct: 141 DGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASE 200 Query: 177 EEMTGY-----VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKA 221 + V T Y APE + + DI+S G ++ E++ G Sbjct: 201 KFAQTVMTSRIVGTTAYMAPEALRGEI--TPKSDIYSFGVVLLEIITGLP 248 >4C59-A nrPDB Length = 340 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 69/306 (22%), Positives = 116/306 (37%), Gaps = 61/306 (19%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK-HE 81 RL+ R + G + V A D ++ A+K+L + R +E+ +K L H Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEE--KNRAIIQEVCFMKKLSGHP 85 Query: 82 NVIGLLDV--FTPATSIEDFSEVYLVTTLMGADLNNIVK----CQALSDEHVQFLVYQLL 135 N++ S +E L+T L L +K LS + V + YQ Sbjct: 86 NIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTC 145 Query: 136 RGLKYIHSAG--IIHRDLKPSNVAVNEDCELRILDFGLA---------------RQADEE 178 R ++++H IIHRDLK N+ ++ +++ DFG A R EE Sbjct: 146 RAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEE 205 Query: 179 MTGYVATRWYRAPEIMLNWMHY--NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 T YR PEI+ + ++ + DIW++GCI+ L + F + RI+ Sbjct: 206 EITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKL----RIV 261 Query: 237 EVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQR 296 + P + L+ ML ++ ++R Sbjct: 262 NGKYSIPP-----------------------------HDTQYTVFHSLIRAMLQVNPEER 292 Query: 297 VSAAEA 302 +S AE Sbjct: 293 LSIAEV 298 >4Y83-A nrPDB Length = 332 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 68/312 (21%), Positives = 123/312 (39%), Gaps = 48/312 (15%) Query: 3 GPRAGFYRQELNKTVWEVPQRLQGLRPVGS-----GAYGSVCSAYDARLRQKVAVKKLSR 57 P+ G Y+ ++ V +P +L R +GS GA+G V A D + ++++A K + Sbjct: 52 TPQNGRYQ--IDSDVLLIPWKLTY-RNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPV 108 Query: 58 PFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV 117 + + +HEN+ L ++ F E G+ L + Sbjct: 109 DQFKPSD-------VEIQACFRHENIAELYGAVLWGETVHLFMEAG----EGGSVLEKLE 157 Query: 118 KCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE 177 C + + + ++ +L+GL ++HS +IH D+KPSN+ V + ++DFGL+ Q E Sbjct: 158 SCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNI-VFMSTKAVLVDFGLSVQMTE 216 Query: 178 EM---TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKR 234 ++ T Y +PE++L H + DI+S+G + + G Sbjct: 217 DVYFPKDLRGTEIYMSPEVILCRGH-STKADIYSLGATLIHMQTGTPP------------ 263 Query: 235 IMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSD 294 K A + L I +P +L+ L + + Sbjct: 264 ------------WVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPN 311 Query: 295 QRVSAAEALAHA 306 R AA+ L H Sbjct: 312 HRPRAADLLKHE 323 >5HVK-A nrPDB Length = 315 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 63/311 (20%), Positives = 111/311 (35%), Gaps = 57/311 (18%) Query: 21 PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKH 80 P L +G G +G + + +K+L R + R +E+++++ L+H Sbjct: 13 PSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEET--QRTFLKEVKVMRCLEH 70 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC--QALSDEHVQFLVYQLLRGL 138 NV+ + V + ++ + G L I+K + G+ Sbjct: 71 PNVLKFIGVLYKDKRLN-----FITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGM 125 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT-----------------G 181 Y+HS IIHR+L N V E+ + + DFGLAR +E T Sbjct: 126 AYLHSMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYT 185 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGT 241 V ++ APE++ N Y++ VD++S G ++ E+ I V Sbjct: 186 VVGNPYWMAPEMI-NGRSYDEKVDVFSFGIVLCEI------------------IGRVNAD 226 Query: 242 PSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAE 301 P + R ++ P P + R LD ++R S + Sbjct: 227 PDYLPRTMDFGLNVRGFLDRYCP----------PNCPPSFFPITVRCCDLDPEKRPSFVK 276 Query: 302 ALAHAYFSQYH 312 L H + Sbjct: 277 -LEH-WLETLR 285 >2OZO-A nrPDB Length = 613 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 56/268 (20%), Positives = 109/268 (40%), Gaps = 36/268 (13%) Query: 3 GPRAGFYRQELNKTVWEVPQRLQGLR-------------PVGSGAYGSVCSAYDARLRQK 49 PR + ++ + P+ L+ + +G G +GSV +++ Sbjct: 304 KPRPMPMDTSVFESPFSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQ 363 Query: 50 --VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTT 107 VA+K L + + RE +++ L + ++ L+ V + LV Sbjct: 364 IDVAIKVLKQGTEK-ADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-------LMLVME 415 Query: 108 LMGA-DLNNIV--KCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCEL 164 + G L+ + K + + +V L++Q+ G+KY+ +HR+L NV + Sbjct: 416 MAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVNRHYA 475 Query: 165 RILDFGLARQADEEMTGY-------VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 +I DFGL++ + + Y +WY APE + N+ ++ D+WS G M E L Sbjct: 476 KISDFGLSKALGADDSYYTARSAGKWPLKWY-APECI-NFRKFSSRSDVWSYGVTMWEAL 533 Query: 218 Q-GKALFPGSDYIDQLKRIMEVVGTPSP 244 G+ + + + I + P Sbjct: 534 SYGQKPYKKMKGPEVMAFIEQGKRMECP 561 >3PP0-A nrPDB Length = 338 Score = 180 bits (457), Expect = 9e-46, Method: Composition-based stats. Identities = 65/274 (23%), Positives = 111/274 (40%), Gaps = 25/274 (9%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKV----AVKKLSRPFQSLIHARRTYRELRLLKHLK 79 L+ ++ +GSGA+G+V + V A+K L R S + E ++ + Sbjct: 19 LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVL-RENTSPKANKEILDEAYVMAGVG 77 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQ-ALSDEHVQFLVYQLLR 136 V LL + +T V LVT LM G L+++ + + L + + Q+ + Sbjct: 78 SPYVSRLLGICLTST-------VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAK 130 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY------VATRWYRA 190 G+ Y+ ++HRDL NV V ++I DFGLAR D + T Y V +W A Sbjct: 131 GMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKW-MA 189 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249 E +L + D+WS G + EL+ G + G + + + P P + Sbjct: 190 LESILRRR-FTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICT- 247 Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAID 283 I + + + + +A D Sbjct: 248 IDVYMIMVKCWMIDSECRPRFRELVSEFSRMARD 281 >5TOS-A nrPDB Length = 395 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 69/341 (20%), Positives = 122/341 (35%), Gaps = 48/341 (14%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAY---------DARLRQKVAV 52 S P F EL + + +G G +G V + +AV Sbjct: 49 STPVKSFTFNELKLAT----RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAV 104 Query: 53 KKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGAD 112 KKL++ + R E+ L L H N++ L+ +ED + + + Sbjct: 105 KKLNQ--EGFQGHREWLTEINYLGQLSHPNLVKLIGYC-----LEDEHRLLVYEFMQKGS 157 Query: 113 LNNIVKCQA-----LSDEHVQFLVYQLLRGLKYIHSA--GIIHRDLKPSNVAVNEDCELR 165 L N + + L + +GL ++HS +I+RD+K SN+ ++ D + Sbjct: 158 LENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAK 217 Query: 166 ILDFGLARQADEEMTGYV-----ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGK 220 + DFGLAR YV T Y APE M + H N D++S G ++ E+L GK Sbjct: 218 LSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM-SSGHLNARSDVYSFGVLLLEILSGK 276 Query: 221 ALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPL 280 R ++ E L + + + + L + + + Sbjct: 277 -------------RALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVR 323 Query: 281 AIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAE 321 + + L + R + + + Q D +P Sbjct: 324 MASVAVQCLSFEPKSRPTMDQVVR--ALQQLQDNLGKPSQT 362 >6CTH-A nrPDB Length = 309 Score = 178 bits (452), Expect = 4e-45, Method: Composition-based stats. Identities = 56/202 (27%), Positives = 100/202 (49%), Gaps = 19/202 (9%) Query: 29 PVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLD 88 +G G +GSV + +AVKK+SR + I + E++++ L+H+N++ L+ Sbjct: 22 KLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGI--KEYASEVKIISRLRHKNLVKLIG 79 Query: 89 VFTPATSIEDFSEVYLVTTLM-GADLN-NIVKCQALSDEHVQF-LVYQLLRGLKYIHSAG 145 + E+ LV M L+ +I K ++L V++ +V L L Y+H G Sbjct: 80 WC------HERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEG 133 Query: 146 ---IIHRDLKPSNVAVNEDCELRILDFGLARQADE----EMTGYVATRWYRAPEIMLNWM 198 ++HRD+K SN+ ++ ++ DFGLAR D + T T Y APE + + Sbjct: 134 DHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECL-SSG 192 Query: 199 HYNQTVDIWSVGCIMAELLQGK 220 ++ D++S G + E+ G+ Sbjct: 193 KASKESDVYSFGVVALEIASGR 214 >4NEU-A nrPDB Length = 333 Score = 177 bits (450), Expect = 6e-45, Method: Composition-based stats. Identities = 56/286 (19%), Positives = 110/286 (38%), Gaps = 52/286 (18%) Query: 32 SGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFT 91 SG +G V + R + + +K + + + H E +++ L+H V+ LL V Sbjct: 34 SGGFGKVSLCFH-RTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVII 92 Query: 92 PATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDEHVQ-FLVYQLLRGLKYIHSAGIIHR 149 + + LV M +L +++K + + V+ ++ +++ G+ Y+H G+IH+ Sbjct: 93 ------EEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHK 146 Query: 150 DLKPSNVAVNEDCELRILDFGLA----------------RQADEEMTGYVATRWYRAPEI 193 DLKP N+ V+ D ++I D GLA R+ D T +Y APE Sbjct: 147 DLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEH 206 Query: 194 MLN-WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 + + + D++S ++ + K + + QL Sbjct: 207 LNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQL-------------------- 246 Query: 253 EHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS 298 I + + D+ I I L+ + + R + Sbjct: 247 ------IMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPT 286 >2A1A-B nrPDB Length = 284 Score = 177 bits (449), Expect = 6e-45, Method: Composition-based stats. Identities = 62/302 (20%), Positives = 120/302 (39%), Gaps = 60/302 (19%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 + + +GSG +G V A + +K++ + + RE++ L L Sbjct: 9 FGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVK------YNNEKAEREVKALAKLD 62 Query: 80 HENVIGLLDVF----------TPATSIEDFSEVYLVTTLMG-ADLNNIV---KCQALSDE 125 H N++ + + +S +++ L + + + L Sbjct: 63 HVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKV 122 Query: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGL--ARQADEEMTGYV 183 L Q+ +G+ YIHS +I+RDLKPSN+ + + +++I DFGL + + D + T Sbjct: 123 LALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSK 182 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL-QGKALFPGSDYIDQLKRIMEVVGTP 242 T Y +PE ++ Y + VD++++G I+AELL F S + L+ Sbjct: 183 GTLRYMSPE-QISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLR--------- 232 Query: 243 SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEA 302 +++ I + +T LL ++L + R + +E Sbjct: 233 -DGIISDIFDKKEKT--------------------------LLQKLLSKKPEDRPNTSEI 265 Query: 303 LA 304 L Sbjct: 266 LR 267 >3Q4U-A nrPDB Length = 301 Score = 177 bits (449), Expect = 7e-45, Method: Composition-based stats. Identities = 74/313 (23%), Positives = 120/313 (38%), Gaps = 61/313 (19%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLK--H 77 V + + L VG G YG V + + VAVK S + +RE L Sbjct: 6 VARDITLLECVGKGRYGEVWRG--SWQGENVAVKIF-----SSRDEKSWFRETELYNTVM 58 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDEHVQFLVYQLLR 136 L+HEN++G + + TS ++++L+T L + ++ L +V + Sbjct: 59 LRHENILGFIA--SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIAS 116 Query: 137 GLKYIH--------SAGIIHRDLKPSNVAVNEDCELRILDFGLA-------RQADEEMTG 181 GL ++H I HRDLK N+ V ++ + I D GLA Q D Sbjct: 117 GLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNP 176 Query: 182 YVATRWYRAPEIMLNWMHYN-----QTVDIWSVGCIMAELLQG----------KALFPGS 226 V T+ Y APE++ + + + VDIW+ G ++ E+ + K F Sbjct: 177 RVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDV 236 Query: 227 DYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLG 286 V PS E + K+ Q P +P + S LA L+ Sbjct: 237 -----------VPNDPSFEDMRKVVC-----VDQQRPNIPNRWFSD--PTLTSLAK-LMK 277 Query: 287 RMLVLDSDQRVSA 299 + R++A Sbjct: 278 ECWYQNPSARLTA 290 >5GNK-A nrPDB Length = 297 Score = 177 bits (449), Expect = 8e-45, Method: Composition-based stats. Identities = 66/288 (22%), Positives = 121/288 (42%), Gaps = 26/288 (9%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKV----AVKKLSRPFQSLIHARRTYRELRLLKHLK 79 + ++ +GSGA+G+V +KV A+K+L R S + E ++ + Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASVD 79 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQ-ALSDEHVQFLVYQLLR 136 + +V LL + +T V L+ LM G L+ + + + + +++ Q+ + Sbjct: 80 NPHVCRLLGICLTST-------VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAK 132 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY------VATRWYRA 190 G+ Y+ ++HRDL NV V ++I DFGLA+ E Y V +W A Sbjct: 133 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW-MA 191 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249 E +L+ + Y D+WS G + EL+ G + G + + + P P + Sbjct: 192 LESILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT- 249 Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV 297 I + + + + +A D R LV+ D+R+ Sbjct: 250 IDVYMIMVKCWMIDADSRPKFRELIIEFSKMARD-PQRYLVIQGDERM 296 >6FER-A nrPDB Length = 309 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 68/319 (21%), Positives = 113/319 (35%), Gaps = 65/319 (20%) Query: 19 EVPQRLQGLR-PVGSGAYGSVCSAY--------------DARLRQKV--AVKKLSRPFQS 61 E P++L + +G G +G V D Q V AVK L Sbjct: 5 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK 64 Query: 62 LIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ- 120 +E++++ LK N+I LL V I D + + DLN + Sbjct: 65 NARN-DFLKEIKIMSRLKDPNIIHLLAVC-----ITDDPLCMITEYMENGDLNQFLSRHE 118 Query: 121 ----------ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFG 170 +S +++F+ Q+ G+KY+ S +HRDL N V ++ ++I DFG Sbjct: 119 PPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFG 178 Query: 171 LARQADE------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFP 224 ++R + + RW I+L + D+W+ G + E F Sbjct: 179 MSRNLYSGDYYRIQGRAVLPIRWMSWESILLG--KFTTASDVWAFGVTLWETFT----FC 232 Query: 225 GSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLP-PMPQKDLSSIFRGANPLAID 283 QL S E + + + E R + P P S+++ Sbjct: 233 QEQPYSQL----------SDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYK-------- 274 Query: 284 LLGRMLVLDSDQRVSAAEA 302 L+ D+ R S E Sbjct: 275 LMLSCWRRDTKNRPSFQEI 293 >3LZB-A nrPDB Length = 327 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 62/274 (22%), Positives = 114/274 (41%), Gaps = 25/274 (9%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKV----AVKKLSRPFQSLIHARRTYRELRLLKHLK 79 + ++ +GSGA+G+V +KV A+K+L R S + E ++ + Sbjct: 17 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASVD 75 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQ-ALSDEHVQFLVYQLLR 136 + +V LL + +T V L+T LM G L+ + + + + +++ Q+ + Sbjct: 76 NPHVCRLLGICLTST-------VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAK 128 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY------VATRWYRA 190 G+ Y+ ++HRDL NV V ++I DFGLA+ E Y V +W A Sbjct: 129 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW-MA 187 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249 E +L+ + Y D+WS G + EL+ G + G + + + P P + Sbjct: 188 LESILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTI 246 Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAID 283 R + + + + +A D Sbjct: 247 DVYMIMRKCWM-IDADSRPKFRELIIEFSKMARD 279 >6HV0-A nrPDB Length = 416 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 82/344 (23%), Positives = 133/344 (38%), Gaps = 72/344 (20%) Query: 29 PVGSGAYGS-VCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK-HENVIGL 86 +G GA G+ V + VAVK++ S RE++LL+ H NVI Sbjct: 15 VLGHGAEGTIVYRGMF--DNRDVAVKRILPECFSFAD-----REVQLLRESDEHPNVIRY 67 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDE--HVQFLVYQLLRGLKYIHSA 144 + +D Y+ L A L V+ + + L+ Q GL ++HS Sbjct: 68 F------CTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSL 121 Query: 145 GIIHRDLKPSNVAV---NEDCELR--ILDFGLARQAD------EEMTGYVATRWYRAPEI 193 I+HRDLKP N+ + N +++ I DFGL ++ +G T + APE+ Sbjct: 122 NIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 181 Query: 194 MLNWMHY--NQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI 250 + TVDI+S GC+ ++ G F G Q ++ Sbjct: 182 LSEDCKENPTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQANILLGACSLDC------- 233 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF-- 308 L P +D+ +A +L+ +M+ +D +R SA L H +F Sbjct: 234 -----------LHPEKHEDV---------IARELIEKMIAMDPQKRPSAKHVLKHPFFWS 273 Query: 309 -----SQYHDPEDEPEAEPYD----ESVEAKERTLE--EWKELT 341 + D D E E D + +E R + +W+E Sbjct: 274 LEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENI 317 >4PL5-B nrPDB Length = 435 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 81/342 (23%), Positives = 130/342 (38%), Gaps = 67/342 (19%) Query: 29 PVGSGAYGS-VCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK-HENVIGL 86 +G GA G+ V + VAVK++ S RE++LL+ H NVI Sbjct: 34 VLGHGAEGTIVYKGMF--DNRDVAVKRILPECFSFAD-----REVQLLRESDEHPNVIRY 86 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDE--HVQFLVYQLLRGLKYIHSA 144 + +D Y+ L A L V+ + + L++Q GL ++HS Sbjct: 87 F------CTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSL 140 Query: 145 GIIHRDLKPSNVAV---NEDCELR--ILDFGLARQAD------EEMTGYVATRWYRAPEI 193 I+HRDLKP N+ + N ++ I DFGL ++ +G T + APE+ Sbjct: 141 NIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 200 Query: 194 MLNWMHY--NQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI 250 + TVDI+S GC+ ++ G F G Q ++ Sbjct: 201 LSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQANILLGACNL--------- 250 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF-- 308 D + + +A +L+ +M+ +D QR SA L H +F Sbjct: 251 ------------------DCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWS 292 Query: 309 -----SQYHDPEDEPEAEPYD-ESVEAKERTLEEWKELTYQE 344 + D D E E D V ER ++ ++E Sbjct: 293 LEKQLQFFQDVSDRIEKEALDGPIVRQLERGGRAVVKMDWRE 334 >2RIO-A nrPDB Length = 434 Score = 174 bits (442), Expect = 5e-44, Method: Composition-based stats. Identities = 79/330 (23%), Positives = 135/330 (40%), Gaps = 78/330 (23%) Query: 19 EVPQRLQGL----RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRL 74 Q L+ L + +G G+ G+V + + VAVK++ F + E++L Sbjct: 8 NFEQSLKNLVVSEKILGYGSSGTVVF-QGSFQGRPVAVKRMLIDFCDI-----ALMEIKL 61 Query: 75 LKHLK-HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQ----- 128 L H NVI S +Y+ L +L ++V+ + +SDE+++ Sbjct: 62 LTESDDHPNVIRYY------CSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEY 115 Query: 129 ---FLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-------------EDCELRILDFGLA 172 L+ Q+ G+ ++HS IIHRDLKP N+ V+ E+ + I DFGL Sbjct: 116 NPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLC 175 Query: 173 RQADEEMTGYV-------ATRWYRAPEI------MLNWMHYNQTVDIWSVGCIMAELLQ- 218 ++ D + + T +RAPE+ + +++DI+S+GC+ +L Sbjct: 176 KKLDSGQSSFRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSK 235 Query: 219 GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGAN 278 GK F G Y + I G S + + + R Sbjct: 236 GKHPF-GDKYSRESNIIR---GIFSLDEMKCLHD----------------------RSLI 269 Query: 279 PLAIDLLGRMLVLDSDQRVSAAEALAHAYF 308 A DL+ +M+ D +R +A + L H F Sbjct: 270 AEATDLISQMIDHDPLKRPTAMKVLRHPLF 299 >4EUU-A nrPDB Length = 319 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 64/303 (21%), Positives = 118/303 (38%), Gaps = 31/303 (10%) Query: 11 QELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTY 69 Q + +W + +G GA +V + A+K + F + + Sbjct: 4 QSTSNHLWLLSD------ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--M 55 Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ----ALSDE 125 RE +LK L H+N++ L + T+ +V ++ L +++ L + Sbjct: 56 REFEVLKKLNHKNIVKLFAIEEETTTRH---KVLIMEFCPCGSLYTVLEEPSNAYGLPES 112 Query: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVA--VNEDCE--LRILDFGLARQA--DEEM 179 ++ ++ G+ ++ GI+HR++KP N+ + ED + ++ DFG AR+ DE+ Sbjct: 113 EFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF 172 Query: 180 TGYVATRWYRAPEIMLN-------WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQL 232 T Y P++ Y TVD+WS+G G F + + Sbjct: 173 VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN 232 Query: 233 KRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLD 292 K +M + T P + I MP S+ RG L +L +L D Sbjct: 233 KEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVS--CSLSRGLQVLLTPVLANILEAD 290 Query: 293 SDQ 295 ++ Sbjct: 291 QEK 293 >4JLC-A nrPDB Length = 657 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 66/303 (21%), Positives = 118/303 (38%), Gaps = 31/303 (10%) Query: 11 QELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTY 69 Q + +W + +G GA +V + AVK + F + + Sbjct: 3 QSTSNHLWLLSD------ILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--M 54 Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ----ALSDE 125 RE +LK L H+N++ L + T+ +V ++ L +++ L + Sbjct: 55 REFEVLKKLNHKNIVKLFAIEEETTTRH---KVLIMEFCPCGSLYTVLEEPSNAYGLPES 111 Query: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVA--VNEDCE--LRILDFGLARQA--DEEM 179 ++ ++ G+ ++ GI+HRD+KP N+ + ED + ++ DFG AR+ DE+ Sbjct: 112 EFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF 171 Query: 180 TGYVATRWYRAPEIMLN-------WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQL 232 T Y P++ Y TVD+WSVG G F + + Sbjct: 172 VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRN 231 Query: 233 KRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLD 292 K +M + T P + I MP S+ +G L +L +L D Sbjct: 232 KEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPLS--CSLSQGLQALLTPVLANILEAD 289 Query: 293 SDQ 295 ++ Sbjct: 290 QEK 292 >4TPT-A nrPDB Length = 303 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 50/219 (22%), Positives = 87/219 (39%), Gaps = 32/219 (14%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 L +G G +G + + +K+L R + + E+++++ L H N Sbjct: 1 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEET--QKTFLTEVKVMRSLDHPN 58 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-QALSDEHVQFLVYQLLRGLKYI 141 V+ + V + L + G L + ++ + + G+ Y+ Sbjct: 59 VLKFIGVLYKDKKLN-----LLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYL 113 Query: 142 HSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT--------------------- 180 HS IIHRDL N + D + + DFGL+R EE Sbjct: 114 HSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKK 173 Query: 181 --GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL 217 V ++ APE MLN Y++TVDI+S G ++ E++ Sbjct: 174 RYTVVGNPYWMAPE-MLNGKSYDETVDIFSFGIVLCEII 211 >4EUT-A nrPDB Length = 396 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 64/303 (21%), Positives = 118/303 (38%), Gaps = 31/303 (10%) Query: 11 QELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTY 69 Q + +W + +G GA +V + A+K + F + + Sbjct: 4 QSTSNHLWLLSD------ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--M 55 Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ----ALSDE 125 RE +LK L H+N++ L + T+ +V ++ L +++ L + Sbjct: 56 REFEVLKKLNHKNIVKLFAIEEETTTRH---KVLIMEFCPCGSLYTVLEEPSNAYGLPES 112 Query: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVA--VNEDCE--LRILDFGLARQA--DEEM 179 ++ ++ G+ ++ GI+HR++KP N+ + ED + ++ DFG AR+ DE+ Sbjct: 113 EFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF 172 Query: 180 TGYVATRWYRAPEIMLN-------WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQL 232 T Y P++ Y TVD+WS+G G F + + Sbjct: 173 VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN 232 Query: 233 KRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLD 292 K +M + T P + I MP S+ RG L +L +L D Sbjct: 233 KEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVS--CSLSRGLQVLLTPVLANILEAD 290 Query: 293 SDQ 295 ++ Sbjct: 291 QEK 293 >3UIU-A nrPDB Length = 306 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 62/315 (19%), Positives = 120/315 (38%), Gaps = 73/315 (23%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 + + +GSG +G V A + ++++ + + RE++ L L Sbjct: 10 FGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVK------YNNEKAEREVKALAKLD 63 Query: 80 HENVIGLLDVF-----------------------TPATSIEDFSEVYLVTTLMG-ADLNN 115 H N++ + + +S +++ L Sbjct: 64 HVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQ 123 Query: 116 IV---KCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGL- 171 + + + L L Q+ +G+ YIHS +IHRDLKPSN+ + + +++I DFGL Sbjct: 124 WIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLV 183 Query: 172 -ARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL-QGKALFPGSDYI 229 + + D + T T Y +PE ++ Y + VD++++G I+AELL F S + Sbjct: 184 TSLKNDGKRTRSKGTLRYMSPE-QISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFF 242 Query: 230 DQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRML 289 L+ +++ I + +T LL ++L Sbjct: 243 TDLR----------DGIISDIFDKKEKT--------------------------LLQKLL 266 Query: 290 VLDSDQRVSAAEALA 304 + R + +E L Sbjct: 267 SKKPEDRPNTSEILR 281 >4IDT-A nrPDB Length = 356 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 76/323 (23%), Positives = 115/323 (35%), Gaps = 65/323 (20%) Query: 19 EVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL 78 EV LR +G G++G V D + + AVKK+ EL L Sbjct: 72 EVHWATHQLR-LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE-------ELMACAGL 123 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-LSDEHVQFLVYQLLRG 137 ++ L + F E+ L G L +VK Q L ++ + + Q L G Sbjct: 124 TSPRIVPLYGAVREGPWVNIFMEL-----LEGGSLGQLVKEQGCLPEDRALYYLGQALEG 178 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDC-ELRILDFGLARQADEEMTGY--------VATRWY 188 L+Y+HS I+H D+K NV ++ D + DFG A + G T + Sbjct: 179 LEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETH 238 Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLA 248 APE++L + VD+WS C+M +L G + + Sbjct: 239 MAPEVVLG-RSCDAKVDVWSSCCMMLHMLNGCHPW---------------TQFFRGPLCL 282 Query: 249 KISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEA------ 302 KI+SE + I PL + L + RVSAAE Sbjct: 283 KIASE-------------PPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNR 329 Query: 303 -------LAHAYFSQYHDPEDEP 318 L + +Y +P P Sbjct: 330 ALQQVGGLKSPWRGEYKEPRHPP 352 >3MDY-A nrPDB Length = 337 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 72/303 (23%), Positives = 122/303 (40%), Gaps = 41/303 (13%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH-- 77 + +++Q ++ +G G YG V +KVAVK ++ +RE + + Sbjct: 35 IAKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEAS-----WFRETEIYQTVL 87 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLR 136 ++HEN++G + T ++++YL+T L + +K L + + L Y + Sbjct: 88 MRHENILGFIAADIKGT--GSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVS 145 Query: 137 GLKYIH--------SAGIIHRDLKPSNVAVNEDCELRILDFGLA-------RQADEEMTG 181 GL ++H I HRDLK N+ V ++ I D GLA + D Sbjct: 146 GLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNT 205 Query: 182 YVATRWYRAPEIM---LNWMHYNQT--VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 V T+ Y PE++ LN H+ D++S G I+ E+ + G QL Sbjct: 206 RVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCV-SGGIVEEYQLPYHD 264 Query: 237 EVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQR 296 V PS E + +I I+ L P SS L+ + R Sbjct: 265 LVPSDPSYEDMREIVC------IKKLRPSFPNRWSS--DECLRQMGKLMTECWAHNPASR 316 Query: 297 VSA 299 ++A Sbjct: 317 LTA 319 >4LRM-A nrPDB Length = 334 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 67/291 (23%), Positives = 122/291 (41%), Gaps = 29/291 (9%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKV----AVKKLSRPFQSLIHARRTYRELRLLKHLK 79 + ++ +GSGA+G+V +KV A+K+L R S + E ++ + Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASVD 79 Query: 80 HE---NVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQ-ALSDEHVQFLVYQ 133 + +V LL + +T V L+T LM G L+ + + + + +++ Q Sbjct: 80 NPGNPHVCRLLGICLTST-------VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ 132 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY------VATRW 187 + +G+ Y+ ++HRDL NV V ++I DFGLA+ E Y V +W Sbjct: 133 IAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW 192 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEV 246 A E +L+ + Y D+WS G + EL+ G + G + + + P P + Sbjct: 193 -MALESILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPI 250 Query: 247 LAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV 297 I + + + + +A D R LV+ D+R+ Sbjct: 251 CT-IDVYMIMVKCWMIDADSRPKFRELIIEFSKMARD-PQRYLVIQGDERM 299 >6O8B-A nrPDB Length = 665 Score = 170 bits (431), Expect = 9e-43, Method: Composition-based stats. Identities = 65/312 (20%), Positives = 119/312 (38%), Gaps = 31/312 (9%) Query: 2 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQ 60 P Q + +W + +G GA +V + A+K + F Sbjct: 1 GSPGLDGICQSTSNHLWLLSD------ILGQGATANVFRGRHKKTGDLFAIKVFNNISFL 54 Query: 61 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ 120 + + RE +LK L H+N++ L + T+ +V ++ L +++ Sbjct: 55 RPVDVQ--MREFEVLKKLNHKNIVKLFAIEEETTTRH---KVLIMEFCPCGSLYTVLEEP 109 Query: 121 ----ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVA--VNEDCE--LRILDFGLA 172 L + ++ ++ G+ ++ GI+HR++KP N+ + ED + ++ DFG A Sbjct: 110 SNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAA 169 Query: 173 RQA--DEEMTGYVATRWYRAPEIMLN-------WMHYNQTVDIWSVGCIMAELLQGKALF 223 R+ DE+ T Y P++ Y TVD+WS+G G F Sbjct: 170 RELEDDEQFVELYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 229 Query: 224 PGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAID 283 + + K +M + T P + I MP S+ RG L Sbjct: 230 RPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVS--CSLSRGLQVLLTP 287 Query: 284 LLGRMLVLDSDQ 295 +L +L D ++ Sbjct: 288 VLANILEADQEK 299 >6NT9-A nrPDB Length = 742 Score = 169 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 64/303 (21%), Positives = 118/303 (38%), Gaps = 31/303 (10%) Query: 11 QELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTY 69 Q + +W + +G GA +V + A+K + F + + Sbjct: 2 QSTSNHLWLLSD------ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--M 53 Query: 70 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ----ALSDE 125 RE +LK L H+N++ L + T+ +V ++ L +++ L + Sbjct: 54 REFEVLKKLNHKNIVKLFAIEEETTTRH---KVLIMEFCPCGSLYTVLEEPSNAYGLPES 110 Query: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVA--VNEDCE--LRILDFGLARQA--DEEM 179 ++ ++ G+ ++ GI+HR++KP N+ + ED + ++ DFG AR+ DE+ Sbjct: 111 EFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF 170 Query: 180 TGYVATRWYRAPEIMLN-------WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQL 232 T Y P++ Y TVD+WS+G G F + + Sbjct: 171 VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN 230 Query: 233 KRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLD 292 K +M + T P + I MP S+ RG L +L +L D Sbjct: 231 KEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVS--CSLSRGLQVLLTPVLANILEAD 288 Query: 293 SDQ 295 ++ Sbjct: 289 QEK 291 >2PMN-X nrPDB Length = 348 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 58/322 (18%), Positives = 117/322 (36%), Gaps = 47/322 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA---------------R 66 + +R + G + + + + A+KK + Sbjct: 31 NDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYD 88 Query: 67 RTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGAD----LNNIV----- 117 EL+++ +K+E T I ++ EVY++ M D + Sbjct: 89 DFKNELQIITDIKNEY------CLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDK 142 Query: 118 -KCQALSDEHVQFLVYQLLRGLKYIH-SAGIIHRDLKPSNVAVNEDCELRILDFGLARQA 175 + + ++ ++ +L YIH I HRD+KPSN+ ++++ +++ DFG + Sbjct: 143 NYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYM 202 Query: 176 -DEEMTGYVATRWYRAPEIMLNWMHY-NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLK 233 D+++ G T + PE N Y VDIWS+G + + F + +L Sbjct: 203 VDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELF 262 Query: 234 RIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDS 293 + P L P+ K + + ID L L + Sbjct: 263 NNIRTKNIEYPLDRNHF-----------LYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNP 311 Query: 294 DQRVSAAEALAHAYFSQYHDPE 315 +R+++ +AL H + + + + Sbjct: 312 AERITSEDALKHEWLADTNIED 333 >1PY5-A nrPDB Length = 326 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 67/303 (22%), Positives = 120/303 (39%), Gaps = 41/303 (13%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLK--H 77 + + + +G G +G V ++VAVK S R +RE + + Sbjct: 27 IARTIVLQESIGKGRFGEVWRGKWR--GEEVAVKIF-----SSREERSWFREAEIYQTVM 79 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLR 136 L+HEN++G + +++++LV+ L + + ++ E + L Sbjct: 80 LRHENILGFIAADNKDN--GTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTAS 137 Query: 137 GLKYIH--------SAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTG------- 181 GL ++H I HRDLK N+ V ++ I D GLA + D Sbjct: 138 GLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNH 197 Query: 182 YVATRWYRAPEIM---LNWMHYN--QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 236 V T+ Y APE++ +N H+ + DI+++G + E+ + ++ G QL Sbjct: 198 RVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYD 256 Query: 237 EVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQR 296 V PS E + K+ E Q L P S +A ++ + R Sbjct: 257 LVPSDPSVEEMRKVVCE------QKLRPNIPNRWQS-CEALRVMAK-IMRECWYANGAAR 308 Query: 297 VSA 299 ++A Sbjct: 309 LTA 311 >3QD2-B nrPDB Length = 332 Score = 168 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 64/336 (19%), Positives = 128/336 (38%), Gaps = 87/336 (25%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 + ++ +G G +G V A + A+K++ P + L + RE++ L L+H Sbjct: 7 DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELA-REKVMREVKALAKLEHPG 65 Query: 83 VIGLLDVF--TPATSIEDFS---------------------------------------- 100 ++ + + TP ++ Sbjct: 66 IVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVG 125 Query: 101 ---------EVYLVTTLMG-ADLNNIVKCQALSDEH----VQFLVYQLLRGLKYIHSAGI 146 +Y+ L +L + + + ++ + Q+ ++++HS G+ Sbjct: 126 QLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGL 185 Query: 147 IHRDLKPSNVAVNEDCELRILDFGLARQADEE---------------MTGYVATRWYRAP 191 +HRDLKPSN+ D +++ DFGL D++ TG V T+ Y +P Sbjct: 186 MHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSP 245 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 E ++ +Y+ VDI+S+G I+ ELL + S +++++ I +V P + + Sbjct: 246 E-QIHGNNYSHKVDIFSLGLILFELL-----YSFSTQMERVRIITDVRNLKFPLLFTQKY 299 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGR 287 + L P P + P A D++ Sbjct: 300 PQEHMMVQDMLSPSPTER---------PEATDIIEN 326 >5WNL-A nrPDB Length = 342 Score = 168 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 69/322 (21%), Positives = 122/322 (37%), Gaps = 46/322 (14%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 VGSG +G V + +A+K E + ++ K ++ + Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVY 85 Query: 88 DVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAG- 145 + V LV M L ++ + L + +V++ G+ ++H Sbjct: 86 GICQEP--------VGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSP 137 Query: 146 -IIHRDLKPSNVAVNEDCELRILDFGLAR------QADEEMTGYVATRWYRAPE-IMLNW 197 ++H +LKP+N+ ++ ++I DFGLA+ D M G T Y PE I Sbjct: 138 PLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKS 197 Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257 ++ D++S ++ +L K F +D + L +M+VV PE Sbjct: 198 RLFDTKHDVYSFAIVIWGVLTQKKPF--ADEKNILHIMMKVVKGHRPE------------ 243 Query: 258 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDE 317 LPP+ + A I L+ R D R + E S+ D ++ Sbjct: 244 ----LPPICRPR-----PRACASLIGLMQRCWHADPQVRPTFQEIT-----SETEDLCEK 289 Query: 318 PEAEPYDESVEAKERTLEEWKE 339 P+ E D + E E++ E K Sbjct: 290 PDEEVKDLAHEPGEKSSLESKS 311 >4F0G-A nrPDB Length = 287 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 51/292 (17%), Positives = 109/292 (37%), Gaps = 51/292 (17%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-----PFQSLIHARRTYRELRLLK 76 ++ + +G G +G V + + VA+K L + + + RE+ ++ Sbjct: 19 NEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMS 78 Query: 77 HLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIV--KCQALSDEHVQFLVYQ 133 +L H N++ L + +V + DL + + K + L+ Sbjct: 79 NLNHPNIVKLYGLMHNPPR--------MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLD 130 Query: 134 LLRGLKYIHSAG--IIHRDLKPSNVA---VNEDCEL--RILDFGLARQADEEMTGYVATR 186 + G++Y+ + I+HRDL+ N+ ++E+ + ++ DFGL++Q+ ++G + Sbjct: 131 IALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVSGLLGNF 190 Query: 187 WYRAPEIM-LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245 + APE + Y + D +S I+ +L G+ F Y ++ + E Sbjct: 191 QWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGK-----IKFINMIREE 245 Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV 297 L E P +++ D +R Sbjct: 246 GLRPTIPE----------------------DCPPRLRNVIELCWSGDPKKRP 275 >2BUJ-A nrPDB Length = 317 Score = 167 bits (423), Expect = 8e-42, Method: Composition-based stats. Identities = 65/327 (19%), Positives = 122/327 (37%), Gaps = 56/327 (17%) Query: 4 PRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLI 63 R Y Q + + ++ +G G + V A+K++ Sbjct: 13 GRENLYFQGHMVII--DNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRIL--CHEQQ 68 Query: 64 HARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV----KC 119 RE + + H N++ L+ + + + L G N I K Sbjct: 69 DREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKG 128 Query: 120 QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM 179 L+++ + +L+ + RGL+ IH+ G HRDLKP+N+ + ++ + ++D G QA + Sbjct: 129 NFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHV 188 Query: 180 TGY------------VATRWYRAPEIMLNWMH--YNQTVDIWSVGCIMAELLQGKALFPG 225 G T YRAPE+ H ++ D+WS+GC++ ++ G+ + Sbjct: 189 EGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY-- 246 Query: 226 SDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLL 285 + + + + V ++S +P P+ + LL Sbjct: 247 -------DMVFQKGDSVALAVQNQLS----------IPQSPRH---------SSALWQLL 280 Query: 286 GRMLVLDSDQRV------SAAEALAHA 306 M+ +D QR S EAL Sbjct: 281 NSMMTVDPHQRPHIPLLLSQLEALQPP 307 >5LPZ-A nrPDB Length = 332 Score = 167 bits (422), Expect = 9e-42, Method: Composition-based stats. Identities = 75/330 (22%), Positives = 130/330 (39%), Gaps = 41/330 (12%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +GSG +G V A + VA+KKL S R E+ + +KH N++ LL Sbjct: 25 IGSGGFGDVYKAI-LKDGSAVAIKKLIHV--SGQGDREFMAEMETIGKIKHRNLVPLLGY 81 Query: 90 FTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQA-----LSDEHVQFLVYQLLRGLKYIHS 143 E LV M L +++ L+ + + RGL ++H Sbjct: 82 CKVG------DERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHH 135 Query: 144 A---GIIHRDLKPSNVAVNEDCELRILDFGLARQADE-----EMTGYVATRWYRAPEIML 195 IIHRD+K SNV ++E+ E R+ DFG+AR ++ T Y PE Sbjct: 136 NCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 ++ + D++S G ++ ELL GK D+ D +VG +IS Sbjct: 196 SFR-CSTKGDVYSYGVVLLELLTGKRPTDSPDFGDN-----NLVGWVKQHAKLRISDVFD 249 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPE 315 ++ P + + L + L + +R + + +A F + Sbjct: 250 PELMKEDPALEIELLQHLKVAVA---------CLDDRAWRRPTMVQVMAM--FKEIQAGS 298 Query: 316 DEPEAEPYDESVEAKERTLEEWKELTYQEV 345 +++ S+E + E +++ +EV Sbjct: 299 G-IDSQSTIRSIEDGGFSTIEMVDMSIKEV 327 >5LPV-A nrPDB Length = 296 Score = 165 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 69/289 (23%), Positives = 114/289 (39%), Gaps = 38/289 (13%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +GSG +G V A + VA+KKL S R E+ + +KH N++ LL Sbjct: 25 IGSGGFGDVYKAI-LKDGSAVAIKKLIHV--SGQGDREFMAEMETIGKIKHRNLVPLLGY 81 Query: 90 FTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQA-----LSDEHVQFLVYQLLRGLKYIHS 143 E LV M L +++ L+ + + RGL ++H Sbjct: 82 CKVG------DERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHH 135 Query: 144 A---GIIHRDLKPSNVAVNEDCELRILDFGLARQADE-----EMTGYVATRWYRAPEIML 195 IIHRD+K SNV ++E+ E R+ DFG+AR ++ T Y PE Sbjct: 136 NCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255 ++ + D++S G ++ ELL GK D+ D +VG +IS Sbjct: 196 SFR-CSTKGDVYSYGVVLLELLTGKRPTDSPDFGDN-----NLVGWVKQHAKLRISDVFD 249 Query: 256 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 ++ P + + L + L + +R + + +A Sbjct: 250 PELMKEDPALEIELLQHLKVAVA---------CLDDRAWRRPTMVQVMA 289 >3SOC-A nrPDB Length = 322 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 70/316 (22%), Positives = 125/316 (39%), Gaps = 44/316 (13%) Query: 4 PRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLI 63 Y Q + LQ L G +G V A L + VAVK P Q Sbjct: 15 GTENLYFQSMP---------LQLLEVKARGRFGCVWKAQ--LLNEYVAVKIF--PIQDKQ 61 Query: 64 HARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQAL 122 + Y E+ L +KHEN++ + TS++ +++L+T L++ +K + Sbjct: 62 SWQNEY-EVYSLPGMKHENILQFIGAEKRGTSVD--VDLWLITAFHEKGSLSDFLKANVV 118 Query: 123 SDEHVQFLVYQLLRGLKYIHS----------AGIIHRDLKPSNVAVNEDCELRILDFGLA 172 S + + + RGL Y+H I HRD+K NV + + I DFGLA Sbjct: 119 SWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLA 178 Query: 173 RQAD-----EEMTGYVATRWYRAPEIMLNWMHYNQ----TVDIWSVGCIMAELLQGKALF 223 + + + G V TR Y APE++ +++ + +D++++G ++ EL Sbjct: 179 LKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAA 238 Query: 224 PGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAID 283 G L E+ PS E + ++ + + ++ + Sbjct: 239 DGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCET------- 291 Query: 284 LLGRMLVLDSDQRVSA 299 + D++ R+SA Sbjct: 292 -IEECWDHDAEARLSA 306 >4FL3-A nrPDB Length = 635 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 58/292 (19%), Positives = 111/292 (38%), Gaps = 53/292 (18%) Query: 20 VPQRLQGL--RPVGSGAYGSVCSAYD--ARLRQKVAVKKLSRPFQSLIHARRTYRELRLL 75 + ++L L + +GSG +G+V Y ++ + VAVK L E ++ Sbjct: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKC-QALSDEHVQFLVYQ 133 + L + ++ ++ + + LV + LN ++ + + D+++ LV+Q Sbjct: 425 QQLDNPYIVRMIGICEAES-------WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQ 477 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY-------VATR 186 + G+KY+ + +HRDL NV + +I DFGL++ + Y + Sbjct: 478 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK 537 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPE 245 WY APE + N+ ++ D+WS G +M E G+ + G + + + P Sbjct: 538 WY-APECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPA 595 Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV 297 G DL+ D + R Sbjct: 596 ------------------------------GCPREMYDLMNLCWTYDVENRP 617 >3AOX-A nrPDB Length = 344 Score = 164 bits (415), Expect = 7e-41, Method: Composition-based stats. Identities = 49/250 (19%), Positives = 92/250 (36%), Gaps = 30/250 (12%) Query: 19 EVPQR-LQGLRPVGSGAYGSVCSAY-----DARLRQKVAVKKLSRPFQSLIHARRTYREL 72 EVP++ + +R +G GA+G V + +VAVK L S E Sbjct: 43 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPE-VCSEQDELDFLMEA 101 Query: 73 RLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA--------LSD 124 ++ H+N++ + V S++ L+ + G DL + ++ L+ Sbjct: 102 LIISKFNHQNIVRCIGV-----SLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAM 156 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDC---ELRILDFGLARQADEEMTG 181 + + + G +Y+ IHRD+ N + +I DFG+AR Sbjct: 157 LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY 216 Query: 182 YVA-----TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRI 235 + PE + + + D WS G ++ E+ G +P + L+ + Sbjct: 217 RKGGCAMLPVKWMPPEAFMEGI-FTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFV 275 Query: 236 MEVVGTPSPE 245 P+ Sbjct: 276 TSGGRMDPPK 285 >6J5U-C nrPDB Length = 426 Score = 164 bits (415), Expect = 7e-41, Method: Composition-based stats. Identities = 59/293 (20%), Positives = 107/293 (36%), Gaps = 40/293 (13%) Query: 30 VGSGAYGSVCSAY---------DARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKH 80 +G G +G V + VAVK+L + + E+ L L H Sbjct: 92 LGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLK--PEGFQGHKEWLTEVNYLGQLSH 149 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC---QALSDEHVQFLVYQLLRG 137 N++ L+ E + + + + L N + Q L+ + +G Sbjct: 150 PNLVLLVGYCA-----EGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAAKG 204 Query: 138 LKYIHSAG--IIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYV-----ATRWYRA 190 L ++H A +I+RD K +N+ ++ D ++ DFGLA+ +V T Y A Sbjct: 205 LTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGYAA 264 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI 250 PE + D++S G ++ EL+ G +R M+ + L Sbjct: 265 PEYVATGRL-TAKSDVYSFGVVLLELISG-------------RRAMDNSNGGNEYSLVDW 310 Query: 251 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEAL 303 ++ + + M K + A +L + L D+ R +E L Sbjct: 311 ATPYLGDKRKLFRIMDTKLGGQYPQKGAFTAANLALQCLNPDAKLRPKMSEVL 363 >3MY0-A nrPDB Length = 305 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 67/313 (21%), Positives = 116/313 (37%), Gaps = 61/313 (19%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH-- 77 V +++ + VG G YG V + VAVK S + +RE + Sbjct: 6 VARQVALVECVGKGRYGEVWRGLWH--GESVAVKIF-----SSRDEQSWFRETEIYNTVL 58 Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLR 136 L+H+N++G + + TS ++++L+T L + ++ Q L L Sbjct: 59 LRHDNILGFIA--SDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAAC 116 Query: 137 GLKYIH--------SAGIIHRDLKPSNVAVNEDCELRILDFGLAR-------QADEEMTG 181 GL ++H I HRD K NV V + + I D GLA D Sbjct: 117 GLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNP 176 Query: 182 YVATRWYRAPEIMLNWMHYN-----QTVDIWSVGCIMAELLQG----------KALFPGS 226 V T+ Y APE++ + + + DIW+ G ++ E+ + + F Sbjct: 177 RVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDV 236 Query: 227 DYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLG 286 V PS E + K+ Q P +P + + + LA ++ Sbjct: 237 -----------VPNDPSFEDMKKVVC-----VDQQTPTIPNRLAAD--PVLSGLA-QMMR 277 Query: 287 RMLVLDSDQRVSA 299 + R++A Sbjct: 278 ECWYPNPSARLTA 290 >5C26-A nrPDB Length = 299 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 58/292 (19%), Positives = 111/292 (38%), Gaps = 53/292 (18%) Query: 20 VPQRLQGL--RPVGSGAYGSVCSAYD--ARLRQKVAVKKLSRPFQSLIHARRTYRELRLL 75 + ++L L + +GSG +G+V Y ++ + VAVK L E ++ Sbjct: 23 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 82 Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKC-QALSDEHVQFLVYQ 133 + L + ++ ++ + + LV + LN ++ + + D+++ LV+Q Sbjct: 83 QQLDNPYIVRMIGICEAES-------WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQ 135 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY-------VATR 186 + G+KY+ + +HRDL NV + +I DFGL++ + Y + Sbjct: 136 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK 195 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPE 245 WY APE + N+ ++ D+WS G +M E G+ + G + + + P Sbjct: 196 WY-APECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPA 253 Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV 297 G DL+ D + R Sbjct: 254 ------------------------------GCPREMYDLMNLCWTYDVENRP 275 >4G3E-A nrPDB Length = 352 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 53/204 (25%), Positives = 86/204 (42%), Gaps = 23/204 (11%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 VG G++G V D + + AVKK+ + EL L ++ L Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVE-------ELVACAGLSSPRIVPLYGA 134 Query: 90 FTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-LSDEHVQFLVYQLLRGLKYIHSAGIIH 148 + F E+ L G L ++K L ++ + + Q L GL+Y+H+ I+H Sbjct: 135 VREGPWVNIFMEL-----LEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILH 189 Query: 149 RDLKPSNVAVNEDC-ELRILDFG--LARQADEEMTGYV------ATRWYRAPEIMLNWMH 199 D+K NV ++ D + DFG L Q D + T + APE+++ Sbjct: 190 GDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMG-KP 248 Query: 200 YNQTVDIWSVGCIMAELLQGKALF 223 + VDIWS C+M +L G + Sbjct: 249 CDAKVDIWSSCCMMLHMLNGCHPW 272 >5TE0-A nrPDB Length = 347 Score = 161 bits (408), Expect = 5e-40, Method: Composition-based stats. Identities = 59/303 (19%), Positives = 104/303 (34%), Gaps = 62/303 (20%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK-HENVIGL 86 + G + V K A+K++ + + RE+++++ L H+N++G Sbjct: 25 EVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQV--CKREIQIMRDLSGHKNIVGY 81 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGA----DLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 +D S D EV ++ +L N ++ V + + +H Sbjct: 82 IDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLH 141 Query: 143 SAG--IIHRDLKPSNVAVNEDCELRILDFGLARQ------------ADEEMTGYVATRWY 188 IIHRDLK N+ +++ + DFG A ++E+ Y T Y Sbjct: 142 QCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYT-TLSY 200 Query: 189 RAPEIMLNWMH--YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEV 246 RAPE++ + DIW++GC++ +L F E Sbjct: 201 RAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF--------------------GES 240 Query: 247 LAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHA 306 I + S L+ ML D D+R + + Sbjct: 241 QVAICDGNFTIPDNSRYSQDMHC--------------LIRYMLEPDPDKRPDIYQV---S 283 Query: 307 YFS 309 YFS Sbjct: 284 YFS 286 >3ZZW-A nrPDB Length = 289 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 57/273 (20%), Positives = 98/273 (35%), Gaps = 37/273 (13%) Query: 25 QGLRPVGSGAYGSVCSAY-----DARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 + + +G +G V + Q VA+K L + + E L L+ Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPL-REEFRHEAMLRARLQ 70 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ-----------------AL 122 H NV+ LL V T + + + DL+ + + AL Sbjct: 71 HPNVVCLLGVVTKDQPLS-----MIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSAL 125 Query: 123 SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEM--- 179 LV Q+ G++Y+ S ++H+DL NV V + ++I D GL R+ Sbjct: 126 EPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYK 185 Query: 180 ---TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRI 235 + RW APE ++ + ++ DIWS G ++ E+ G + G D ++ I Sbjct: 186 LLGNSLLPIRW-MAPEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMI 243 Query: 236 MEVVGTPSPEVLAKISSEHARTYIQSLPPMPQK 268 P P+ P + Sbjct: 244 RNRQVLPCPDDCPAWVYALMIECWNEFPSRRPR 276 >5WNO-A nrPDB Length = 330 Score = 158 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 54/255 (21%), Positives = 99/255 (38%), Gaps = 27/255 (10%) Query: 28 RPVGSGAYGSVCSA-----YDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 + +G+GA+G+V + ++ VA+K E + L+H+N Sbjct: 28 KKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVF---QTDQSQTDEMLEEATNMFRLRHDN 84 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA--LSDEHVQFLVYQLLRGLKY 140 ++ ++ + D + +L N +K L YQ+ G++Y Sbjct: 85 LLKIIGFC-----MHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQY 139 Query: 141 IHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE------MTGYVATRWYRAPEIM 194 + ++HRDL NV V + + I DFGL++ + +G VA +W A EI Sbjct: 140 LEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKW-LAIEIF 198 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGS--DYIDQLKRIMEVVGTPSPEVLAKIS 251 Y D+W+ G E++ G++ + G D I + + P P + Sbjct: 199 SKHC-YTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQP-PNCSQDLY 256 Query: 252 SEHARTYIQSLPPMP 266 E R ++ P Sbjct: 257 QELLRCWMADPKSRP 271 >4F9B-A nrPDB Length = 361 Score = 157 bits (398), Expect = 5e-39, Method: Composition-based stats. Identities = 81/361 (22%), Positives = 136/361 (37%), Gaps = 73/361 (20%) Query: 11 QELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYD---ARLRQKVAVKKLSRPFQSLIHARR 67 ++L + V ++ + +G G + SV A +K+A+K L H R Sbjct: 10 EKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPT----SHPIR 65 Query: 68 TYRELRLLKHLK-HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEH 126 EL+ L +NV+G+ F + V + L +I+ LS + Sbjct: 66 IAAELQCLTVAGGQDNVMGVKYCFRKNDHV-----VIAMPYLEHESFLDILNS--LSFQE 118 Query: 127 VQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE-LRILDFGLARQADE-------- 177 V+ + L + LK IH GI+HRD+KPSN N + ++DFGLA+ + Sbjct: 119 VREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKF 178 Query: 178 -----------------------EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMA 214 ++ T +RAPE++ + +D+WS G I Sbjct: 179 VQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFL 238 Query: 215 ELLQGKALFP-GSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSI 273 LL G+ F SD + L +IM + G+ + A + + + +P + L Sbjct: 239 SLLSGRYPFYKASDDLTALAQIMTIRGS-RETIQAAKTFGKSILCSKEVPAQDLRKLCER 297 Query: 274 FRGANPLAIDLLGRM------LV------------------LDSDQRVSAAEALAHAYFS 309 RG + L + L L+ R++A EAL H +F Sbjct: 298 LRGMDSSTPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFK 357 Query: 310 Q 310 Sbjct: 358 D 358 >5XD6-A nrPDB Length = 305 Score = 157 bits (398), Expect = 6e-39, Method: Composition-based stats. Identities = 54/222 (24%), Positives = 90/222 (40%), Gaps = 28/222 (12%) Query: 19 EVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL 78 ++ +G G+YG V + + A+KKL S + ++ ++ L Sbjct: 19 DITDNYGSKSLIGEGSYGRVFYGI-LKSGKAAAIKKLD---SSKQPDQEFLAQVSMVSRL 74 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA----------LSDEHVQ 128 + ENV+ LL V L++I+ + LS Sbjct: 75 RQENVVALLGYCVDGP-----LRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRV 129 Query: 129 FLVYQLLRGLKYIHSA---GIIHRDLKPSNVAVNEDCELRILDFGLARQADE-----EMT 180 + RGL+Y+H +IHRD+K SNV + +D +I DF L+ QA + T Sbjct: 130 KIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHST 189 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKAL 222 + T Y APE + + D++S G ++ ELL G+ Sbjct: 190 RVLGTFGYHAPEYAMTGTL-STKSDVYSFGVVLLELLTGRKP 230 >3G2F-A nrPDB Length = 336 Score = 156 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 112/310 (36%), Gaps = 46/310 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLK--HLK 79 L+ L +G G YG+V + + VAVK S + + E + + ++ Sbjct: 13 DNLKLLELIGRGRYGAVYKG--SLDERPVAVKVF-----SFANRQNFINEKNIYRVPLME 65 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKCQALSDEHVQFLVYQLLRGL 138 H+N+ + V + + E LV L + L + + RGL Sbjct: 66 HDNIARFI-VGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGL 124 Query: 139 KYIH---------SAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-----------DEE 178 Y+H I HRDL NV V D I DFGL+ + D Sbjct: 125 AYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNA 184 Query: 179 MTGYVATRWYRAPEIMLN------WMHYNQTVDIWSVGCIMAELLQGKA-LFPGSDYID- 230 V T Y APE++ + VD++++G I E+ LFPG + Sbjct: 185 AISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEY 244 Query: 231 QLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLV 290 Q+ EV P+ E + + S R + P K+ S R D Sbjct: 245 QMAFQTEVGNHPTFEDMQVLVS---REKQRPKFPEAWKENSLAVRSLKETIED----CWD 297 Query: 291 LDSDQRVSAA 300 D++ R++A Sbjct: 298 QDAEARLTAQ 307 >2H34-A nrPDB Length = 309 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 63/227 (27%), Positives = 100/227 (44%), Gaps = 14/227 (6%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS-LIHARRTYRELRLLKHLKHEN 82 + R VG G G V A D + VA+K +S S + R RE R L+ + Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVKCQA-LSDEHVQFLVYQLLRGLKY 140 V+ + D E ++Y+ L+ DL +++ Q L+ +V Q+ L Sbjct: 96 VVPIHDF------GEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDA 149 Query: 141 IHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY----VATRWYRAPEIMLN 196 H+AG HRD+KP N+ V+ D ++DFG+A +E V T +Y APE + Sbjct: 150 AHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERF-S 208 Query: 197 WMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPS 243 H DI+++ C++ E L G + G I + + PS Sbjct: 209 ESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPS 255 >5AR8-A nrPDB Length = 326 Score = 155 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 66/326 (20%), Positives = 122/326 (37%), Gaps = 41/326 (12%) Query: 5 RAGFYRQELNKTVW-----EVP-QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKL-SR 57 + Y Q +N +P +L LR + GA G+V SA A R +VAVK L Sbjct: 9 KENLYFQGMNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIH 68 Query: 58 PFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNI 116 + RE +L + ++ +L + + +VT M LN + Sbjct: 69 TPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLG------IVTEYMPNGSLNEL 122 Query: 117 VKCQALSDEHVQ----FLVYQLLRGLKYIHSAG--IIHRDLKPSNVAVNEDCELRILDFG 170 + + + +++++ G+ Y+H+ ++H DLK N+ ++ + ++I DFG Sbjct: 123 LHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFG 182 Query: 171 LARQADEEMTGYV--------ATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLQGK 220 L++ ++ T Y PE + DI+S I E+L K Sbjct: 183 LSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRK 242 Query: 221 ALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPL 280 F D + L+ + V P + +E + Y + S + Sbjct: 243 QPF--EDVTNPLQIMYSVSQGHRP-----VINEESLPYDIPHRARMISLIESGWAQNPDE 295 Query: 281 AIDLLGRMLVLDSDQR----VSAAEA 302 L ++ L+ R ++ EA Sbjct: 296 RPSFLKCLIELEPVLRTFEEITFLEA 321 >3UIM-A nrPDB Length = 326 Score = 153 bits (388), Expect = 8e-38, Method: Composition-based stats. Identities = 47/214 (21%), Positives = 85/214 (39%), Gaps = 20/214 (9%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 +G G +G V VAVK+L + E+ ++ H Sbjct: 30 DNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEERTQGGELQ-FQTEVEMISMAVHR 87 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA-----LSDEHVQFLVYQLLR 136 N++ L T + + + + + ++ + L Q + R Sbjct: 88 NLLRLRGFCMTPTE-----RLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSAR 142 Query: 137 GLKYIHSA---GIIHRDLKPSNVAVNEDCELRILDFGLARQADEE----MTGYVATRWYR 189 GL Y+H IIHRD+K +N+ ++E+ E + DFGLA+ D + T T + Sbjct: 143 GLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHI 202 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLQGKALF 223 APE + ++ D++ G ++ EL+ G+ F Sbjct: 203 APEYLSTGKS-SEKTDVFGYGVMLLELITGQRAF 235 >5E8V-A nrPDB Length = 316 Score = 153 bits (388), Expect = 8e-38, Method: Composition-based stats. Identities = 65/298 (21%), Positives = 117/298 (39%), Gaps = 42/298 (14%) Query: 30 VGSGAYGSVCSAYDARLR----QKVAVKKLS-RPFQSLIHARRTYRELRLLKHLKHENVI 84 VG G + V A + + VAVK + S + + ++ +LKHEN++ Sbjct: 17 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDI----NLKHENIL 72 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHS 143 L T + + +L+T +L + +S E ++ L L RG+ ++HS Sbjct: 73 QFLTAEERKTELG--KQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS 130 Query: 144 AG---------IIHRDLKPSNVAVNEDCELRILDFGLARQADEEM-------TGYVATRW 187 I+HRDLK SN+ V D + DFGL+ + D + +G V T Sbjct: 131 DHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTAR 190 Query: 188 YRAPEIMLNWMHYN-----QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTP 242 Y APE++ + M+ + D++S+ ++ E+ + + ++K G+ Sbjct: 191 YMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSR------CNAVGEVKDYEPPFGSK 244 Query: 243 SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 300 E S P +P L+ + L D + R++A Sbjct: 245 VREHPCVASMADNVLADAGRPEIPSFWLNHQGIQM---VCETLTECWDHDPEARLTAQ 299 >4M66-A nrPDB Length = 325 Score = 153 bits (388), Expect = 9e-38, Method: Composition-based stats. Identities = 47/212 (22%), Positives = 98/212 (46%), Gaps = 21/212 (9%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 + L+ L VG G +G V A+ VAVK ++ +++ E++ + +L++E Sbjct: 20 EELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVN--------SKKISWEVKAMVNLRNE 71 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ-ALSDEHVQFLVYQLLRGLKY 140 NV+ LL V + + + L +++ + + L+ +++ G+ Y Sbjct: 72 NVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCY 131 Query: 141 IHSAG--IIHRDLKPSNVAVNEDCELRILDFGLAR---------QADEEMTGYVATRWYR 189 +HS ++HRDLKPSN+ ++ + ++ DFGL+ + T Y Sbjct: 132 LHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYL 191 Query: 190 APEIMLN-WMHYNQTVDIWSVGCIMAELLQGK 220 PE++ + ++ D++S G ++ +L G+ Sbjct: 192 DPELLFKVNLKASKASDVYSFGILVWAVLAGR 223 >2QKW-B nrPDB Length = 321 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 59/284 (20%), Positives = 110/284 (38%), Gaps = 33/284 (11%) Query: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89 +G G +G V R KVA+K R +S E+ L +H +++ L+ Sbjct: 47 IGHGVFGKVYKGV-LRDGAKVALK--RRTPESSQGIEEFETEIETLSFCRHPHLVSLIGF 103 Query: 90 FTPATSIEDFSEVYLVTTLMGADLNNIVKCQAL-----SDEHVQFLVYQLLRGLKYIHSA 144 + + + + +L + L S E + RGL Y+H+ Sbjct: 104 CDERNEM-----ILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTR 158 Query: 145 GIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYV-----ATRWYRAPEIMLNWMH 199 IIHRD+K N+ ++E+ +I DFG++++ E ++ T Y PE + Sbjct: 159 AIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRL 218 Query: 200 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI 259 + D++S G ++ E+L ++ S + + V + + L +I + I Sbjct: 219 -TEKSDVYSFGVVLFEVLCARSAIVQSLPREMVNLAEWAVESHNNGQLEQIVDPNLADKI 277 Query: 260 QSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEAL 303 + R A+ + L L S+ R S + L Sbjct: 278 RP----------ESLRKFGDTAV----KCLALSSEDRPSMGDVL 307 >2Y4I-B nrPDB Length = 319 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 47/225 (20%), Positives = 103/225 (45%), Gaps = 28/225 (12%) Query: 18 WEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLK 76 W++P ++L+ +G G +G V R +VA++ + + + RE+ + Sbjct: 28 WDIPFEQLEIGELIGKGRFGQVY---HGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYR 84 Query: 77 HLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA--LSDEHVQFLVYQL 134 +HENV+ + + + + G L ++V+ L + + ++ Sbjct: 85 QTRHENVVLFMGACMSPPHLAIITSLC-----KGRTLYSVVRDAKIVLDVNKTRQIAQEI 139 Query: 135 LRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGL--------ARQADEEMTGYVATR 186 ++G+ Y+H+ GI+H+DLK NV + + ++ I DFGL A + ++++ Sbjct: 140 VKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWL 198 Query: 187 WYRAPEIM--------LNWMHYNQTVDIWSVGCIMAELLQGKALF 223 + APEI+ + + +++ D++++G I EL + F Sbjct: 199 CHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPF 243 >5IKW-A nrPDB Length = 310 Score = 151 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 65/340 (19%), Positives = 118/340 (34%), Gaps = 64/340 (18%) Query: 12 ELNKTVWEVPQRLQGLRP-VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR 70 + V+ V + L + G + +V + A+K++ ++ R Sbjct: 3 SVGVRVFAVGRHQVTLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNV--CKR 59 Query: 71 ELRLLKHLK-HENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKC--QALSDE 125 E+ ++K L H+N++G LD + ++ EV ++ G +N + K ++ Sbjct: 60 EITIMKELSGHKNIVGYLD-CAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEP 118 Query: 126 HVQFLVYQLLRGLKYIHSAG--IIHRDLKPSNVAVNEDCELRILDFGLARQ--------- 174 V + + +H IIHRDLK N+ +N+ + DFG A Sbjct: 119 EVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDG 178 Query: 175 ---ADEEMTGYVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYI 229 +EE+ Y T YRAPE++ DIW++GC++ +L F Sbjct: 179 VNVVEEEIKKYT-TLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF------ 231 Query: 230 DQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRML 289 E +P S L+ ML Sbjct: 232 ----------------------GESQVAICDGNFTIPDNSRYSRNIHC------LIRFML 263 Query: 290 VLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEA 329 D + R + +YF+ D P + + S+ + Sbjct: 264 EPDPEHRPDIFQV---SYFAFKFAAADCPVSNINNSSIPS 300 >6DC0-A nrPDB Length = 292 Score = 150 bits (379), Expect = 8e-37, Method: Composition-based stats. Identities = 48/238 (20%), Positives = 93/238 (39%), Gaps = 44/238 (18%) Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK-CQALSDEHVQFLVYQLLRG 137 H N+ G+++V T + Y+ D+++ V+ + L +E L Q++ Sbjct: 56 SHSNITGIVEVILGET------KAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSA 109 Query: 138 LKYIHSAGIIHRDLKPSNVAVN--EDCELRIL---DFGLARQADEEMTGYVATRWYRAPE 192 + + H + I+ DLK + E +LR+ D + + D+ ++ Y +PE Sbjct: 110 VAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPE 169 Query: 193 IMLNWMHYN-QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 I+ Y+ + D+WS+G ++ LL G+ F SD +I + Sbjct: 170 ILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHI----- 224 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 +P A L+ +L + +R++A E L H +F Sbjct: 225 --------------------------SPKARCLIRSLLRREPSERLTAPEILLHPWFE 256 >5CEK-A nrPDB Length = 263 Score = 150 bits (379), Expect = 9e-37, Method: Composition-based stats. Identities = 48/238 (20%), Positives = 93/238 (39%), Gaps = 44/238 (18%) Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK-CQALSDEHVQFLVYQLLRG 137 H N+ G+++V T + Y+ D+++ V+ + L +E L Q++ Sbjct: 59 SHSNITGIVEVILGET------KAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSA 112 Query: 138 LKYIHSAGIIHRDLKPSNVAVN--EDCELRIL---DFGLARQADEEMTGYVATRWYRAPE 192 + + H + I+ DLK + E +LR+ D + + D+ ++ Y +PE Sbjct: 113 VAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPE 172 Query: 193 IMLNWMHYN-QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 I+ Y+ + D+WS+G ++ LL G+ F SD +I + Sbjct: 173 ILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHI----- 227 Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 +P A L+ +L + +R++A E L H +F Sbjct: 228 --------------------------SPKARCLIRSLLRREPSERLTAPEILLHPWFE 259 >3SV0-A nrPDB Length = 483 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 57/287 (19%), Positives = 114/287 (39%), Gaps = 37/287 (12%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 V + + R +GSG++G + + + ++VA+K + + + E ++ + L+ Sbjct: 5 VGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHP----QLLYESKIYRILQ 60 Query: 80 H----ENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--CQALSDEHVQFLVYQ 133 N + V + LV L+G L ++ + LS + V L Q Sbjct: 61 GGTGIPN-VRWFGV--------EGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQ 111 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVN---EDCELRILDFGLARQADEEMT---------- 180 ++ ++++HS +HRD+KP N + ++ I+DFGLA++ + T Sbjct: 112 MINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENK 171 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGS---DYIDQLKRIME 237 T Y + L ++ D+ S+G ++ L+G + G + ++I E Sbjct: 172 NLTGTARYASVNTHLGIEQ-SRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISE 230 Query: 238 VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDL 284 S E L + +Y + + D + L DL Sbjct: 231 KKVATSIEALCRGYPTEFASYFHYCRSL-RFDDKPDYSYLKRLFRDL 276 >6BFN-A nrPDB Length = 342 Score = 147 bits (371), Expect = 7e-36, Method: Composition-based stats. Identities = 46/213 (21%), Positives = 77/213 (36%), Gaps = 29/213 (13%) Query: 29 PVGSGAYGSVCSAYDARLRQKVAVKKLSR--PFQSLIHARRTYRELRLLKHLKHENVIGL 86 +G G +G V A AVK+L + + E+ L +H N++ Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 87 LDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ-----ALSDEHVQFLVYQLLRGLKYI 141 ++ + L L + + CQ LS ++ R ++++ Sbjct: 87 AGYCA-----QNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFL 141 Query: 142 H--SAGIIHRDLKPSNVAVNEDCELRILDFGLAR------------QADEEMTGYVATRW 187 H S +IH D+K SNV ++E ++ DFGLAR T Sbjct: 142 HQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLA 201 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGK 220 Y PE + D +S G ++ E L G+ Sbjct: 202 YL-PEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >3LMG-A nrPDB Length = 344 Score = 147 bits (371), Expect = 8e-36, Method: Composition-based stats. Identities = 48/236 (20%), Positives = 102/236 (43%), Gaps = 22/236 (9%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQ----KVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 L+ L+ +GSG +G+V + V +K + T L + L Sbjct: 33 LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAI-GSLD 91 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKCQA-LSDEHVQFLVYQLLR 136 H +++ LL + P +S++ LVT + G+ L+++ + + L + + Q+ + Sbjct: 92 HAHIVRLLGLC-PGSSLQ------LVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAK 144 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW-----YRAP 191 G+ Y+ G++HR+L NV + ++++ DFG+A + + + + A Sbjct: 145 GMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMAL 204 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEV 246 E + ++ Y D+WS G + EL+ G + G + + + P++ Sbjct: 205 ESI-HFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQI 259 >4TN6-A nrPDB Length = 318 Score = 147 bits (371), Expect = 8e-36, Method: Composition-based stats. Identities = 58/259 (22%), Positives = 107/259 (41%), Gaps = 28/259 (10%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 V R + R +GSG++G + D ++VA+K + + + E ++ K ++ Sbjct: 5 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHP----QLHIESKIYKMMQ 60 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--CQALSDEHVQFLVYQLLRG 137 G + + T + +V L+G L ++ + S + V L Q++ Sbjct: 61 -----GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISR 115 Query: 138 LKYIHSAGIIHRDLKPSNVAVN---EDCELRILDFGLARQADEEMT----------GYVA 184 ++YIHS IHRD+KP N + + + I+DFGLA++ + T Sbjct: 116 IEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTG 175 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG---SDYIDQLKRIMEVVGT 241 T Y + L ++ D+ S+G ++ G + G + + +RI E + Sbjct: 176 TARYASINTHLGIEQ-SRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMS 234 Query: 242 PSPEVLAKISSEHARTYIQ 260 EVL K TY+ Sbjct: 235 TPIEVLCKGYPSEFATYLN 253 >2QLU-A nrPDB Length = 314 Score = 146 bits (370), Expect = 9e-36, Method: Composition-based stats. Identities = 67/302 (22%), Positives = 120/302 (39%), Gaps = 37/302 (12%) Query: 20 VPQ-RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL 78 VP+ LQ L G +G V A + VAVK + + RE+ + Sbjct: 12 VPRGSLQLLEIKARGRFGCVWKAQ--LMNDFVAVKIFPLQDKQSWQSE---REIFSTPGM 66 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSDEHVQFLVYQLLRG 137 KHEN++ + +++E E++L+T L + +K ++ + + + RG Sbjct: 67 KHENLLQFIAAEKRGSNLE--VELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRG 124 Query: 138 LKYIHS-----------AGIIHRDLKPSNVAVNEDCELRILDFGLARQADE-----EMTG 181 L Y+H I HRD K NV + D + DFGLA + + + G Sbjct: 125 LSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHG 184 Query: 182 YVATRWYRAPEIMLNWMHYNQ----TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME 237 V TR Y APE++ +++ + +D++++G ++ EL+ G L E Sbjct: 185 QVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEE 244 Query: 238 VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV 297 + PS E L ++ + L+ + + D++ R+ Sbjct: 245 IGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVT--------IEECWDHDAEARL 296 Query: 298 SA 299 SA Sbjct: 297 SA 298 >4BTK-A nrPDB Length = 337 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 60/261 (22%), Positives = 107/261 (40%), Gaps = 33/261 (12%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR-ELRLLKHL 78 V R + L+ +G G +G + A D R+ VA+K +S ++ + E+ +LK L Sbjct: 54 VKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV-----ESAQQPKQVLKMEVAVLKKL 108 Query: 79 KHE-NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA---LSDEHVQFLVYQL 134 + + +V + + Y+V L G +L ++ + Q + L Q+ Sbjct: 109 QGKDHVCRFIGC------GRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQI 162 Query: 135 LRGLKYIHSAGIIHRDLKPSNV----AVNEDCELRILDFGLARQADEEM---------TG 181 L ++ IHS G +HRD+KPSN + + +LDFGLARQ G Sbjct: 163 LESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAG 222 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGT 241 + T Y + N + D+WS+ ++ E G+ + +Q+ I E Sbjct: 223 FRGTVRYASVNAHKNRE-MGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKY-- 279 Query: 242 PSPEVLAKISSEHARTYIQSL 262 +L K ++ + Sbjct: 280 -EHRMLLKHMPSEFHLFLDHI 299 >4NFN-A nrPDB Length = 309 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 60/261 (22%), Positives = 107/261 (40%), Gaps = 33/261 (12%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR-ELRLLKHL 78 V R + L+ +G G +G + A D R+ VA+K +S ++ + E+ +LK L Sbjct: 19 VKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV-----ESAQQPKQVLKMEVAVLKKL 73 Query: 79 KHE-NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA---LSDEHVQFLVYQL 134 + + +V + + Y+V L G +L ++ + Q + L Q+ Sbjct: 74 QGKDHVCRFIGC------GRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQI 127 Query: 135 LRGLKYIHSAGIIHRDLKPSNV----AVNEDCELRILDFGLARQADEEM---------TG 181 L ++ IHS G +HRD+KPSN + + +LDFGLARQ G Sbjct: 128 LESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAG 187 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGT 241 + T Y + N + D+WS+ ++ E G+ + +Q+ I E Sbjct: 188 FRGTVRYASVNAHKNRE-MGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKY-- 244 Query: 242 PSPEVLAKISSEHARTYIQSL 262 +L K ++ + Sbjct: 245 -EHRMLLKHMPSEFHLFLDHI 264 >2CHL-A nrPDB Length = 351 Score = 144 bits (364), Expect = 5e-35, Method: Composition-based stats. Identities = 63/306 (20%), Positives = 117/306 (38%), Gaps = 38/306 (12%) Query: 4 PRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLI 63 Y Q + V V + + +G G +G + + + VA+K Sbjct: 14 GTENLYFQSMG--VLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKL----EPMKS 67 Query: 64 HARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--CQA 121 A + + E R K L + I + F P +V L+G L ++ + Sbjct: 68 RAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRT 122 Query: 122 LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE-----LRILDFGLARQ-A 175 S + V + QL+ ++Y+HS +I+RD+KP N + + I+DF LA++ Sbjct: 123 FSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYI 182 Query: 176 DEEMTGYV---------ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG- 225 D E ++ T Y + L ++ D+ ++G + L+G + G Sbjct: 183 DPETKKHIPYREHKSLTGTARYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGL 241 Query: 226 --SDYIDQLKRIMEVVGTPSPEVLAKISSEHART--YIQSLPPMPQKDLSSIFRGANPLA 281 ++ ++I + EVL + E A Y++ L + D + + L Sbjct: 242 KADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRK----LF 297 Query: 282 IDLLGR 287 DL R Sbjct: 298 TDLFDR 303 >5J0A-A nrPDB Length = 300 Score = 143 bits (362), Expect = 8e-35, Method: Composition-based stats. Identities = 65/306 (21%), Positives = 119/306 (38%), Gaps = 47/306 (15%) Query: 26 GLRPVGSGAYGS---VCSAYDARLRQKV---AVKKLS---RPFQSLIHARRTYRELRLLK 76 ++ +G +G+ V + AVKK++ ++ +R E ++LK Sbjct: 13 FMQKLG---FGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILK 69 Query: 77 HLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVKCQ------ALSDEHVQF 129 L H N++G FT A + + L G LN++++ + + Sbjct: 70 SLHHPNIVG-YRAFTEA----NDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILK 124 Query: 130 LVYQLLRGLKYIHS-AGIIHRDLKPSNVAVNEDCE-LRILDFGLARQADEEMTG------ 181 + + RGLKY+H ++H D+K SNV + D E ++I D G++ DE M Sbjct: 125 VALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEAC 184 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGT 241 Y+ T ++ E + DI++ G + E++ +I+ + T Sbjct: 185 YIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP-----HINLSNDDDDEDKT 239 Query: 242 PSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA- 300 E + + PP+ ++L ++ I+L D R SAA Sbjct: 240 FDESDFDD---EAYYAALGTRPPINMEELDESYQKV----IELFSVCTNEDPKDRPSAAH 292 Query: 301 --EALA 304 EAL Sbjct: 293 IVEALE 298 >5FQD-C nrPDB Length = 341 Score = 143 bits (362), Expect = 9e-35, Method: Composition-based stats. Identities = 56/265 (21%), Positives = 111/265 (41%), Gaps = 28/265 (10%) Query: 14 NKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELR 73 +K + V + + +R +GSG++G + A + ++VAVK S+ + + E + Sbjct: 11 SKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHP----QLLYESK 66 Query: 74 LLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--CQALSDEHVQFLV 131 L K L+ G + + ++ LV L+G L ++ + + + V L Sbjct: 67 LYKILQ-----GGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLA 121 Query: 132 YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE---LRILDFGLARQADEEMT-------- 180 Q++ ++Y+H+ IHRD+KP N + L ++DFGLA++ + T Sbjct: 122 DQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYRE 181 Query: 181 --GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG---SDYIDQLKRI 235 T Y + L ++ D+ S+G ++ + + G + + ++I Sbjct: 182 DKNLTGTARYASINAHLGIEQ-SRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKI 240 Query: 236 MEVVGTPSPEVLAKISSEHARTYIQ 260 E + EVL K Y+ Sbjct: 241 SEKKMSTPVEVLCKGFPAEFAMYLN 265 >4LQP-A nrPDB Length = 508 Score = 143 bits (362), Expect = 9e-35, Method: Composition-based stats. Identities = 34/163 (20%), Positives = 69/163 (42%), Gaps = 9/163 (5%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ-SLIHARRTYRELRLLKHLKH 80 + ++ +G GA+G V + A+K L + E +L Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 81 ENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNN-IVKCQALSDEHVQFLVYQLLRGL 138 V+ L F +D +YL+ + G DL +++ Q +++ +F + + + + Sbjct: 162 PWVVSLYYSF------QDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAI 215 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTG 181 + IH G IHR +KP N+ ++ +++ DFGL+ + Sbjct: 216 ETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDS 258 Score = 87.3 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 38/130 (29%), Positives = 49/130 (37%), Gaps = 33/130 (25%) Query: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTP 242 V T Y APEI L + Y Q D WS+G IM E L G F + ++IM T Sbjct: 324 VGTPDYIAPEIFL-YQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTL 382 Query: 243 SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV----S 298 IS E A DL+ R+L +DQR+ Sbjct: 383 QFPDDIHISYE---------------------------AEDLIRRLLTH-ADQRLGRHGG 414 Query: 299 AAEALAHAYF 308 A E +H +F Sbjct: 415 ADEIKSHPFF 424 >5VC6-A nrPDB Length = 289 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 58/303 (19%), Positives = 104/303 (34%), Gaps = 54/303 (17%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL-KHEN 82 L +GSG +GSV A+K+ +P + + RE+ L +H + Sbjct: 13 FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH 72 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 V+ + + +E +L A N + ++ L+ Q+ RGL+YIH Sbjct: 73 VVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIH 132 Query: 143 SAGIIHRDLKPSNVAVNEDCEL-------------------RILDFGLARQADEEMTGYV 183 S ++H D+KPSN+ ++ +I D G + Sbjct: 133 SMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEE- 191 Query: 184 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPS 243 + A E++ + DI+++ + G P DQ I + Sbjct: 192 GDSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLP--RNGDQWHEIRQG----- 243 Query: 244 PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEAL 303 LP +PQ + +LL M+ D ++R SA + Sbjct: 244 -----------------RLPRIPQV--------LSQEFTELLKVMIHPDPERRPSAMALV 278 Query: 304 AHA 306 H+ Sbjct: 279 KHS 281 >5L2Q-C nrPDB Length = 320 Score = 138 bits (349), Expect = 2e-33, Method: Composition-based stats. Identities = 55/304 (18%), Positives = 110/304 (36%), Gaps = 67/304 (22%) Query: 39 CSAYDARLRQKVAVKKL------SRPFQSLIHARRTY---RELRLLKHLK-HENVIGLLD 88 C A +K L + +S + E LL L + V+ Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 89 VFTPATSI------------EDFSEVYLVTT-LMGADLNN-----------IVKCQALSD 124 +F T + + LV L D ++ ++K + LS+ Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE-LRILDFGLARQADEE---MT 180 + Y ++R ++ +H I+HRDLK N+ +N+ + I +F L + E + Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240 + Y +P+++ + + D+W++G ++ +L G+ F S + ++I Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEY 272 Query: 241 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 300 T + + + L+ ++LVLD QR++AA Sbjct: 273 TIPEDGR-----------------------------VSENTVCLIRKLLVLDPQQRLAAA 303 Query: 301 EALA 304 + L Sbjct: 304 DVLE 307 >2CMW-A nrPDB Length = 310 Score = 138 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 60/285 (21%), Positives = 114/285 (40%), Gaps = 34/285 (11%) Query: 25 QGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVI 84 + + +G G +G + + + VA+K P +S A + + E R K L Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK--LEPIKS--RAPQLHLEYRFYKQLGSAGE- 57 Query: 85 GLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--CQALSDEHVQFLVYQLLRGLKYIH 142 GL V+ +V L+G L ++ + + + V + QLL ++Y+H Sbjct: 58 GLPQVYYFGPC---GKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVH 114 Query: 143 SAGIIHRDLKPSNVAVNEDCE-----LRILDFGLARQ-ADEEMTGYV---------ATRW 187 S +I+RD+KP N + + I+DFGLA++ D E ++ T Sbjct: 115 SKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTAR 174 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG---SDYIDQLKRIMEVVGTPSP 244 Y + L ++ D+ ++G + L+G + G ++ ++I + Sbjct: 175 YMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPI 233 Query: 245 EVLAKISSEHARTYIQSLPPMP--QKDLSSIFRGANPLAIDLLGR 287 E L + E TY++ + + +K R L DL + Sbjct: 234 EALCENFPEEMATYLRYVRRLDFFEKPDYEYLRT---LFTDLFEK 275 >2C47-A nrPDB Length = 313 Score = 138 bits (347), Expect = 4e-33, Method: Composition-based stats. Identities = 60/290 (20%), Positives = 116/290 (40%), Gaps = 35/290 (12%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 + + + +G G +G + + + VA+K P +S A + + E R K L Sbjct: 2 MGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIK--LEPIKS--RAPQLHLEYRFYKQLS 57 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--CQALSDEHVQFLVYQLLRG 137 + + F P +V L+G L ++ + + + V + QL+ Sbjct: 58 ATEGVPQVYYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITR 112 Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCE-----LRILDFGLARQ-ADEEMTGYV-------- 183 ++Y+H+ +I+RD+KP N V + I+DFGLA++ D E ++ Sbjct: 113 MEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSL 172 Query: 184 -ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG---SDYIDQLKRIMEVV 239 T Y + L ++ D+ ++G + L+G + G ++ ++I + Sbjct: 173 TGTARYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTK 231 Query: 240 GTPSPEVLAKISSEHARTYIQSLPPMP--QKDLSSIFRGANPLAIDLLGR 287 EVL + E TY++ + + +K R L DL R Sbjct: 232 RATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRK---LFTDLFDR 278 >4NT4-A nrPDB Length = 312 Score = 136 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 57/296 (19%), Positives = 113/296 (38%), Gaps = 43/296 (14%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL- 78 V + + +G G +G + + + VA+K A + + E R K L Sbjct: 10 VGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKM----EPMKSKAPQLHLEYRFYKLLG 65 Query: 79 KH----ENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--CQALSDEHVQFLVY 132 H + G+ ++ T ++ +V L+G L ++ + S + V + Sbjct: 66 SHADNAPD--GIPRIYHLGTCGGRYNA--MVLELLGLSLEDLFNICARKFSLKTVLMIAK 121 Query: 133 QLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE-----LRILDFGLARQADE---------- 177 QLL ++Y+HS +I+RD+KP N + + I+DFGLA++ + Sbjct: 122 QLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYR 181 Query: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG---SDYIDQLKR 234 E T Y + + ++ D+ ++G + L+G + G ++ ++ Sbjct: 182 EHKSLTGTARYMSINTHMGREQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQK 240 Query: 235 IMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLV 290 I + EVL E TY++ + + + D L R+ Sbjct: 241 IGDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDY---------DFLRRLFQ 287 >4M69-B nrPDB Length = 283 Score = 136 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 50/236 (21%), Positives = 100/236 (42%), Gaps = 21/236 (8%) Query: 36 GSVCSAYDARLRQKVAVKKLSRP-FQSLIHARRTYR-ELRLLKHLKHENVIGLLDVFTPA 93 ++ R V +K + P +S+ R T+ E++ +K N++ + + Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 80 Query: 94 TSIEDFSEVYLVTTLMG-ADLNNIV-KCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDL 151 T E +V L ++ + + L+ LV + RGL +H + +HR++ Sbjct: 81 TV--KPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNI 138 Query: 152 KPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW-------YRAPEIMLN-WMHYNQT 203 S+ V ++++ F L++ + +T+ Y +PE + N + Y+ Sbjct: 139 SSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIK 198 Query: 204 VDIWSVGCIMAELLQGKALFPGSDYIDQLK-----RIMEVVGTPSPEVLAKISSEH 254 +I+S G ++ E+ GK F G D + + E VG PE+L +I +E Sbjct: 199 AEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINEC 254 >4BTF-A nrPDB Length = 469 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 50/236 (21%), Positives = 100/236 (42%), Gaps = 21/236 (8%) Query: 36 GSVCSAYDARLRQKVAVKKLSRP-FQSLIHARRTYR-ELRLLKHLKHENVIGLLDVFTPA 93 ++ R V +K + P +S+ R T+ E++ +K N++ + + Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 266 Query: 94 TSIEDFSEVYLVTTLMG-ADLNNIV-KCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDL 151 T E +V L ++ + + L+ LV + RGL +H + +HR++ Sbjct: 267 TV--KPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNI 324 Query: 152 KPSNVAVNEDCELRILDFGLARQADEEMTGYVATRW-------YRAPEIMLN-WMHYNQT 203 S+ V ++++ F L++ + +T+ Y +PE + N + Y+ Sbjct: 325 SSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIK 384 Query: 204 VDIWSVGCIMAELLQGKALFPGSDYIDQLK-----RIMEVVGTPSPEVLAKISSEH 254 +I+S G ++ E+ GK F G D + + E VG PE+L +I +E Sbjct: 385 AEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINEC 440 >2PZI-A nrPDB Length = 681 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 54/254 (21%), Positives = 102/254 (40%), Gaps = 17/254 (6%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDAR-LRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL 78 V + + + G G + A D + V +K L + A + L + Sbjct: 78 VAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAE-RQFLAEV 136 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGL 138 H +++ + + F T Y+V +G K Q L + ++L L Sbjct: 137 VHPSIVQIFN-FVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPAL 195 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWM 198 Y+HS G+++ DLKP N+ + E+ +L+++D G + + Y T ++APEI+ Sbjct: 196 SYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY-GTPGFQAPEIVRTGP 253 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 DI++VG +A L G V G P + + K + R Sbjct: 254 --TVATDIYTVGRTLAALTLDLPTRNGR----------YVDGLPEDDPVLKTYDSYGRLL 301 Query: 259 IQSLPPMPQKDLSS 272 +++ P P++ ++ Sbjct: 302 RRAIDPDPRQRFTT 315 >4Y12-A nrPDB Length = 375 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 54/254 (21%), Positives = 102/254 (40%), Gaps = 17/254 (6%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDAR-LRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL 78 V + + + G G + A D + V +K L + A + L + Sbjct: 117 VAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAE-RQFLAEV 175 Query: 79 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGL 138 H +++ + + F T Y+V +G K Q L + ++L L Sbjct: 176 VHPSIVQIFN-FVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPAL 234 Query: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWM 198 Y+HS G+++ DLKP N+ + E+ +L+++D G + + Y T ++APEI+ Sbjct: 235 SYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY-GTPGFQAPEIVRTGP 292 Query: 199 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 258 DI++VG +A L G V G P + + K + R Sbjct: 293 --TVATDIYTVGRTLAALTLDLPTRNGR----------YVDGLPEDDPVLKTYDSYGRLL 340 Query: 259 IQSLPPMPQKDLSS 272 +++ P P++ ++ Sbjct: 341 RRAIDPDPRQRFTT 354 >3VHK-A nrPDB Length = 368 Score = 128 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 47/209 (22%), Positives = 91/209 (43%), Gaps = 21/209 (10%) Query: 94 TSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKP 153 +E+ S + DL L+ EH+ +Q+ +G++++ S IHRDL Sbjct: 173 GFVEEKSLSDVEEEEAPEDLYK----DFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAA 228 Query: 154 SNVAVNEDCELRILDFGLARQADEEMTGYV-ATRW----YRAPEIMLNWMHYNQTVDIWS 208 N+ ++E ++I DFGLAR ++ + APE + + + Y D+WS Sbjct: 229 RNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRV-YTIQSDVWS 287 Query: 209 VGCIMAELLQ-GKALFPGSDYIDQL-KRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP 266 G ++ E+ G + +PG ++ +R+ E +P+ + E +T + P Sbjct: 288 FGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYT---TPEMYQTMLDCWHGEP 344 Query: 267 QKDLSSIFRGANPLAIDLLGRMLVLDSDQ 295 + R ++ LG +L ++ Q Sbjct: 345 SQ------RPTFSELVEHLGNLLQANAQQ 367 Score = 84.6 bits (208), Expect = 7e-17, Method: Composition-based stats. Identities = 33/119 (27%), Positives = 52/119 (43%), Gaps = 12/119 (10%) Query: 10 RQELNKTVWEVPQ-RLQGLRPVGSGAYGSVCSA----YDAR-LRQKVAVKKLSRPFQSLI 63 R + + WE P+ RL+ +P+G GA+G V A D + VAVK L Sbjct: 16 RLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE 75 Query: 64 HARRTYRELRLLKHLKHE-NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA 121 H R EL++L H+ H NV+ LL T + +V +L+ ++ + Sbjct: 76 H-RALMSELKILIHIGHHLNVVNLLGACTKPG----GPLMVIVEFCKFGNLSTYLRSKR 129 >5VDK-A nrPDB Length = 297 Score = 128 bits (322), Expect = 4e-30, Method: Composition-based stats. Identities = 55/310 (17%), Positives = 105/310 (33%), Gaps = 62/310 (20%) Query: 19 EVPQRLQG----LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRL 74 + R + + +G G +G+V A+K+ + F L + E+ Sbjct: 8 NMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYA 67 Query: 75 LKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQ 133 L H +V+ + + +E +L A N + ++ ++ Q Sbjct: 68 HAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQ 127 Query: 134 LLRGLKYIHSAGIIHRDLKPSNVAVNEDCE-----------------------LRILDFG 170 + GL YIH++ ++H D+KPSN+ + + +I D G Sbjct: 128 ISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLG 187 Query: 171 LARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID 230 A ++ + A EI+ + DI+++G +A + G Sbjct: 188 HATSINKPKVEE-GDSRFLANEILQEDYRHLPKADIFALGLTIA-VAAGA---------- 235 Query: 231 QLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLV 290 E L + + P +PQ+ + LL M+ Sbjct: 236 --------------ESLPTNGAAWHHIRKGNFPDVPQE--------LSESFSSLLKNMIQ 273 Query: 291 LDSDQRVSAA 300 D++QR SAA Sbjct: 274 PDAEQRPSAA 283 >5X18-A nrPDB Length = 295 Score = 127 bits (319), Expect = 8e-30, Method: Composition-based stats. Identities = 51/289 (17%), Positives = 109/289 (37%), Gaps = 35/289 (12%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 V + + +G G++G + + VA+K R ++ + E + K L Sbjct: 5 VGLHYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAP----QLRDEYKTYKILN 60 Query: 80 H-ENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--CQALSDEHVQFLVYQLLR 136 N+ ++ LV L+G L ++ + S + V + Q++ Sbjct: 61 GTPNI------PYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMIT 114 Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCE-----LRILDFGLARQADE----------EMTG 181 ++ +H+ +I+RD+KP N + + + ++DFG+A+Q + E Sbjct: 115 LIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKS 174 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG---SDYIDQLKRIMEV 238 T Y + L ++ D+ ++G + L+G + G + + ++I E Sbjct: 175 LSGTARYMSINTHLGREQ-SRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEK 233 Query: 239 VGTPSPEVLAKISSEHARTYIQ---SLPPMPQKDLSSIFRGANPLAIDL 284 + + LA+ Y++ SL D + + DL Sbjct: 234 KRSTNVYDLAQGLPVQFGRYLEIVRSLSFEECPDYEGYRKLLLSVLDDL 282 >4XHH-A nrPDB Length = 403 Score = 126 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 60/286 (20%), Positives = 112/286 (39%), Gaps = 31/286 (10%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 V ++ + R +GSG++G + + ++VA+ H + Y E R+ K+L Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQLDY-ESRVYKYLS 60 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--CQALSDEHVQFLVYQLLRG 137 I + F +V L+G L ++ + S + V L Q++ Sbjct: 61 GGVGIPFIRWFGREGEYNA-----MVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICR 115 Query: 138 LKYIHSAGIIHRDLKPSNVAVN---EDCELRILDFGLARQADE----------EMTGYVA 184 ++YIH IHRD+KP N + + ++DFGL+++ + E Sbjct: 116 VQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTG 175 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG---SDYIDQLKRIMEVVGT 241 T Y + L ++ D+ S+G ++ +G + G + + RI+E Sbjct: 176 TARYASVNTHLGIEQ-SRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLC 234 Query: 242 PSPEVLAKISSEHARTYI---QSLPPMPQKDLSSIFRGANPLAIDL 284 S E L Y+ ++L + D + R L+I L Sbjct: 235 ISVETLCAGLPLEFSEYMNYCRNLKFDERPDYLYLARLFKDLSIKL 280 >3HNG-A nrPDB Length = 360 Score = 126 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 42/193 (21%), Positives = 79/193 (40%), Gaps = 38/193 (19%) Query: 119 CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE 178 + ++ E + +Q+ RG++++ S IHRDL N+ ++E+ ++I DFGLAR + Sbjct: 193 KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKN 252 Query: 179 MTGYVA--TRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQL 232 TR + APE + + + Y+ D+WS G ++ E+ G + +PG + Sbjct: 253 PDYVRKGDTRLPLKWMAPESIFDKI-YSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDF 311 Query: 233 -KRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVL 291 R+ E + +PE + P ++ Sbjct: 312 CSRLREGMRMRAPEY------------------------------STPEIYQIMLDCWHR 341 Query: 292 DSDQRVSAAEALA 304 D +R AE + Sbjct: 342 DPKERPRFAELVE 354 Score = 82.3 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 30/119 (25%), Positives = 51/119 (42%), Gaps = 12/119 (10%) Query: 10 RQELNKTVWEVP-QRLQGLRPVGSGAYGSVCSA-----YDARLRQKVAVKKLSRPFQSLI 63 R + + WE +RL+ + +G GA+G V A + + VAVK L + Sbjct: 14 RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATA-S 72 Query: 64 HARRTYRELRLLKHLKHE-NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA 121 + EL++L H+ H NV+ LL T + +V +L+N +K + Sbjct: 73 EYKALMTELKILTHIGHHLNVVNLLGACTKQG----GPLMVIVEYCKYGNLSNYLKSKR 127 >4RT7-A nrPDB Length = 415 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 44/178 (24%), Positives = 75/178 (42%), Gaps = 25/178 (14%) Query: 70 RELRLLKHLKHEN---VIGLLD-VFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDE 125 RE+++ H + + GL F IE ++ L DLN L+ E Sbjct: 198 REVQI-----HPDSDQISGLHGNSFHSEDEIEYENQKRLEEE---EDLN------VLTFE 243 Query: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYV-A 184 + YQ+ +G++++ +HRDL NV V ++I DFGLAR + V Sbjct: 244 DLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRG 303 Query: 185 TRW----YRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIME 237 + APE + + Y D+WS G ++ E+ G +PG ++++ Sbjct: 304 NARLPVKWMAPESLFEGI-YTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQ 360 Score = 92.3 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 31/120 (25%), Positives = 52/120 (43%), Gaps = 13/120 (10%) Query: 9 YRQELNKTVWEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQ-----KVAVKKLSRPFQSL 62 +R+ WE P + L+ + +GSGA+G V +A + + +VAVK L S Sbjct: 51 FREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADS- 109 Query: 63 IHARRTYRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA 121 EL+++ L HEN++ LL T + I + DL N ++ + Sbjct: 110 SEREALMSELKMMTQLGSHENIVNLLGACTLSGPI-----YLIFEYCCYGDLLNYLRSKR 164 >4JRN-A nrPDB Length = 372 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 54/317 (17%), Positives = 99/317 (31%), Gaps = 73/317 (23%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR-RTYRELRLLKHLKH 80 + L P+GSG + +V A D +++AVK + RE ++ Sbjct: 68 RTLVRGAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSL 127 Query: 81 ----------------ENVIGLLD------VFTPATSIEDFSEVYLVTTLMGADLNNIV- 117 +V+ L V T+ + L+ AD++ ++ Sbjct: 128 AKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMM-RAEADMSKVIS 186 Query: 118 --------KCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDF 169 +L Q ++ + + + GI+H D+KP+N + +D L + DF Sbjct: 187 WVFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDF 246 Query: 170 GLARQADEEMTGYVATRWYRAPE--IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD 227 G R + + + T Y PE + Y D W +G + + + P Sbjct: 247 GTYR-INNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPADG 305 Query: 228 YIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGR 287 D L + L DL+ Sbjct: 306 IWDYLH-------------------------------------FADCPSTPELVQDLIRS 328 Query: 288 MLVLDSDQRVSAAEALA 304 +L D +R+ +AL Sbjct: 329 LLNRDPQKRMLPLQALE 345 >4XHL-A nrPDB Length = 394 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 58/283 (20%), Positives = 108/283 (38%), Gaps = 29/283 (10%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK 79 V ++ + R +GSG++G + + ++VA+ H + Y E R+ ++L Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQLDY-ESRVYRYLS 60 Query: 80 HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--CQALSDEHVQFLVYQLLRG 137 I + F +V L+G L ++ + S + V L Q+ Sbjct: 61 GGVGIPFIRWFGREGEYNA-----MVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCR 115 Query: 138 LKYIHSAGIIHRDLKPSNVAVN---EDCELRILDFGLARQADE----------EMTGYVA 184 ++YIH IHRD+KP N + + ++DFGL+++ + E Sbjct: 116 IQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTG 175 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG---SDYIDQLKRIMEVVGT 241 T Y + L ++ D+ S+G ++ +G + G + + RIME Sbjct: 176 TARYASVNTHLGIEQ-SRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLN 234 Query: 242 PSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDL 284 S E L + Y+ + + D + L DL Sbjct: 235 VSVETLCSGLPLEFQEYMAYCKNL-KFDEKPDYLFLARLFKDL 276 >4MWI-A nrPDB Length = 294 Score = 124 bits (312), Expect = 5e-29, Method: Composition-based stats. Identities = 44/269 (16%), Positives = 96/269 (35%), Gaps = 45/269 (16%) Query: 50 VAVKKLSRPFQSLI--HARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTT 107 VA+K + I + +E++ +K + N++ + + T + +V Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETV--TPPQFSIVME 107 Query: 108 LMG-ADLNNIV-KCQALSDEHVQFLVYQLLRGLKYIHSAGI--IHRDLKPSNVAVNEDCE 163 L ++ + + L+ LV RGL +H + +H ++ SN V + + Sbjct: 108 YCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQ 167 Query: 164 LRILDFGLARQADE-------EMTGYVATRWYRAP-EIMLNWMHYNQTVDIWSVGCIMAE 215 +++ F L + E T V + Y +P E+ + Y+ +I+S G ++ E Sbjct: 168 VKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWE 227 Query: 216 LLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFR 275 + G F G + +++++++ V P + Sbjct: 228 IATGDIPFQGCNS-EKIRKLVAVKRQQEP----------------------------LGE 258 Query: 276 GANPLAIDLLGRMLVLDSDQRVSAAEALA 304 +++ D R S E L Sbjct: 259 DCPSELREIIDECRAHDPSVRPSVDEILK 287 >1CSN-A nrPDB Length = 298 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 47/257 (18%), Positives = 94/257 (36%), Gaps = 30/257 (11%) Query: 23 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 + R +G G++G + + Q+VA+K R YR +LL Sbjct: 11 HYKVGRRIGEGSFGVIFEGTNLLNNQQVAIK-FEPRRSDAPQLRDEYRTYKLLAGCT--- 66 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--CQALSDEHVQFLVYQLLRGLKY 140 + ++ LV L+G L +++ + S + V Q+L ++ Sbjct: 67 -----GIPNVYYFGQEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQS 121 Query: 141 IHSAGIIHRDLKPSNVAVNEDCE-----LRILDFGLARQADEEMT----------GYVAT 185 IH +++RD+KP N + + ++DFG+ + + +T T Sbjct: 122 IHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGT 181 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG---SDYIDQLKRIMEVVGTP 242 Y + L ++ D+ ++G + L+G + G + + +RI E + Sbjct: 182 ARYMSINTHLGREQ-SRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKKQST 240 Query: 243 SPEVLAKISSEHARTYI 259 L E Y+ Sbjct: 241 PLRELCAGFPEEFYKYM 257 >5X1R-A nrPDB Length = 302 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 56/280 (20%), Positives = 107/280 (38%), Gaps = 40/280 (14%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVK---------------------KLSRPFQ 60 + +G G +G V AYD +L + +A+K + + FQ Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 61 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ 120 + +++ +E RLL H ++ +L + + ++ Y G L N+ Q Sbjct: 81 AGLNS--FIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFY-----SGTTLKNLQAQQ 133 Query: 121 --ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD-- 176 + + ++ L+ L + IH G +HRD+ N+ + E +LDFG AR+ Sbjct: 134 PEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGN 193 Query: 177 -EEMTGYVATRWYRAPEIMLNW--MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLK 233 + T V + E DI+++G ++ L+ G + ++ Sbjct: 194 LSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP-----PVSVVR 248 Query: 234 RIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSI 273 I + + A S E RT ++L P+ +I Sbjct: 249 SIEDSYQPLTERRPAGYSPELLRTVDRALALKPEDRPQTI 288 >4L68-A nrPDB Length = 340 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 59/270 (21%), Positives = 105/270 (38%), Gaps = 33/270 (12%) Query: 36 GSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATS 95 G+ A +AVK LS + R E+ L L+H N+ LL Sbjct: 54 GTTYKAL-LPDGSALAVKHLS---TCKLGEREFRYEMNQLWELRHSNLAPLLGFC----- 104 Query: 96 IEDFSEVYLVTTLMGADLNNIV--KCQALSDEHVQFLVYQLLRGLKYIHSAG---IIHRD 150 + + + + + L++++ L + RGL ++H I+H++ Sbjct: 105 VVEEEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQN 164 Query: 151 LKPSNVAVNEDCELRILDFGLARQA-------DEEMTGYVATRWYRAPEIMLNWMHYNQT 203 + S + ++ED + RI+D GLAR MTG + Y APE M + Sbjct: 165 ICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEY-STTMLASLK 223 Query: 204 VDIWSVGCIMAELLQGKAL-----FPGS--DYIDQLKRIMEVVGTPSPEVLAKISSEHAR 256 D++ +G ++ EL G F GS D++ QL+ + T + K E Sbjct: 224 GDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDEEIS 283 Query: 257 TYIQ----SLPPMPQKDLSSIFRGANPLAI 282 +++ + P++ S + AI Sbjct: 284 KFVEIALNCVSSRPKERWSMFQAYQSLKAI 313 >4L00-A nrPDB Length = 304 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 50/309 (16%), Positives = 99/309 (32%), Gaps = 68/309 (22%) Query: 20 VPQRLQGLRPVGSGAYGSVCSAY------DARLRQKVAVKKLSRPFQ-SLIHARRTYREL 72 + + L +G G + S D ++ +K + + S + E Sbjct: 23 LKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEA 82 Query: 73 -RLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGA---DLNNIVKCQALSDEHVQ 128 +++ + H++++ L V E +V + DL K L+ Sbjct: 83 ASMMRQVSHKHIVYLYGVCVR------DVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKF 136 Query: 129 FLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE-------LRILDFG-----LARQAD 176 + QL L Y+ ++H ++ N+ + + +++ D G L+RQ Sbjct: 137 KVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQEC 196 Query: 177 EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAEL-LQGKALFPGSDYIDQLKRI 235 E + APE + + + + D WS G + E+ G+ Sbjct: 197 IER------IPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIP------------- 237 Query: 236 MEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQ 295 + K E R Y + + LA DL+ R + D +Q Sbjct: 238 ----------LKDKTLIEKERFY--------ESRCRPVTPSCKELA-DLMTRCMNYDPNQ 278 Query: 296 RVSAAEALA 304 R + Sbjct: 279 RPFFRAIMR 287 >5M07-A nrPDB Length = 276 Score = 107 bits (268), Expect = 6e-24, Method: Composition-based stats. Identities = 44/208 (21%), Positives = 76/208 (36%), Gaps = 27/208 (12%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH-ARRTYRELRLLKHLKHEN 82 +R +G+ A G V A+K LS + RR RE + L H + Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 83 VIGLLDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVKCQ---ALSDEHVQFLVYQLLRGL 138 ++ + D E ++++ + D + + L V +V + L Sbjct: 92 ILEVHD------RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGAL 145 Query: 139 KYIHSAGIIHRDLKPSNVAVNE----DCELRILDFGLARQADEEMTGYVATRWYRAPEIM 194 Y H G++HRD+ P+NV + D + + DFG+A Q Y APE+ Sbjct: 146 DYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-----------PSYPAPELS 194 Query: 195 LNWMHYNQTVDIWSVGCIMAELLQGKAL 222 + D +++ L G Sbjct: 195 AG-ADVDGRADQYALALTAIHLFAGAPP 221 >5OAT-A nrPDB Length = 411 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 66/339 (19%), Positives = 107/339 (31%), Gaps = 94/339 (27%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDAR-----LRQKVAVKKL---SRPFQSLIHARRTYRE-- 71 L +P+ G G V SA + A+K + S+ + YRE Sbjct: 11 NDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETV 70 Query: 72 -LRLL-----------------KHLK-HENVIGLLDVFTPATSI-----------EDFSE 101 R+ KHL H N++ + VFT Sbjct: 71 PARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMS 130 Query: 102 VYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-- 159 ++L+ +L + + S L+ QLL G+ ++ + GI HRDLK N+ ++ Sbjct: 131 LFLLMKRYDCNLQSFLSTAP-STRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTS 189 Query: 160 --EDCELRILDFGLARQADEEMTGYVATRWY----------RAPEIMLNWMH------YN 201 E L I DFG AD+ + Y APEI+ Y+ Sbjct: 190 EPESPILVISDFG-CCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYS 248 Query: 202 QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQS 261 D+W+VG I E+ F G + + EV I + Sbjct: 249 -KADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEVPTVIQA--------- 298 Query: 262 LPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 300 L+ +L + ++R+ Sbjct: 299 ----------------------LVANLLKRNPNKRLDPE 315 >5USZ-A nrPDB Length = 289 Score = 105 bits (263), Expect = 3e-23, Method: Composition-based stats. Identities = 45/290 (15%), Positives = 103/290 (35%), Gaps = 40/290 (13%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQ-------KVAVKKLSRPFQSLIHARRTYRELRL 74 + L +G G + + + +V +K L + ++ ++ + + Sbjct: 8 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRN--YSESFFEAASM 65 Query: 75 LKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQA--LSDEHVQFLV 131 + L H++++ V E LV + L+ +K ++ + Sbjct: 66 MSKLSHKHLVLNYGVCVCG------DENILVQEFVKFGSLDTYLKKNKNCINILWKLEVA 119 Query: 132 YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE--------LRILDFGLARQA--DEEMTG 181 QL + ++ +IH ++ N+ + + + +++ D G++ + + Sbjct: 120 KQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQE 179 Query: 182 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVG 240 + + PE + N + N D WS G + E+ G D +L+ + Sbjct: 180 RIP---WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQ 236 Query: 241 TPSPEVLAKISSEHARTYIQSLP--PMPQKDLSSIFRGANPLAI-DLLGR 287 P+P+ +E A + P + +I R N L DL+ R Sbjct: 237 LPAPKA-----AELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPDLVPR 281 >5CLR-A nrPDB Length = 451 Score = 104 bits (260), Expect = 5e-23, Method: Composition-based stats. Identities = 42/192 (21%), Positives = 74/192 (38%), Gaps = 21/192 (10%) Query: 39 CSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIED 98 Y + +K + +SL E L L L+ F + Sbjct: 96 FKVYALDDGKTYFLKSVKIDAESLTE---FTNEKDTLSKLG-----RLVGTFFNE---QT 144 Query: 99 FSEVYLVTTLMGADLNNIVKCQALSDE-----HVQFLVYQLLRGLKYIHSAGIIHRDLKP 153 L T + G DL+ L+ V ++ + +K H G+IHRDLKP Sbjct: 145 QVHYILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKP 204 Query: 154 SNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEI--MLNWMHYNQTVDIWSVGC 211 N+ ++ D + ++DFG + E T Y APE+ +++ ++Q D++++ Sbjct: 205 GNIMLDADMQCHLVDFGSSSSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAY 264 Query: 212 IMAELLQGKALF 223 + EL F Sbjct: 265 SLDELFN---PF 273 >3REP-A nrPDB Length = 271 Score = 103 bits (258), Expect = 1e-22, Method: Composition-based stats. Identities = 47/258 (18%), Positives = 90/258 (34%), Gaps = 22/258 (8%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81 ++L L + G + + VK L S +R E L+ H Sbjct: 10 KQLNFLTKLNENHSGELWKGRWQ--GNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHP 67 Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQA---LSDEHVQFLVYQLLRG 137 NV+ +L + L+T M L N++ + + RG Sbjct: 68 NVLPVLGACQSPPAPHPT----LITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARG 123 Query: 138 LKYIHSAG-IIHR-DLKPSNVAVNEDCELRI--LDFGLARQADEEMTGYVATRWYRAPEI 193 + ++H+ +I R L +V ++ED RI D + Q+ M + APE Sbjct: 124 MAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQSPGRMYA----PAWVAPEA 179 Query: 194 MLNWMHYN--QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251 + ++ D+WS ++ EL+ + F ++ ++ + P + IS Sbjct: 180 LQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKV--ALEGLRPTIPPGIS 237 Query: 252 SEHARTYIQSLPPMPQKD 269 ++ + P K Sbjct: 238 PHVSKLMKICMNEDPAKR 255 >4CI6-B nrPDB Length = 643 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 57/281 (20%), Positives = 112/281 (39%), Gaps = 41/281 (14%) Query: 54 KLSRPFQSLIHARRTYRELRLLKHL-----KHENVIGLLDVFTPATSIEDFSEVYLVTTL 108 +L + I + EL KH+ KH N+ + + L+ Sbjct: 70 RLVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHG--MAVVPYGNRYYYALLMDE 127 Query: 109 MGA--------DLNNIVKCQALSDE----HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNV 156 + L + K ++ E ++F+ ++LL ++ AGI+H D+KP NV Sbjct: 128 VDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIKPGNV 187 Query: 157 AVNE-DCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAE 215 + E ++D GL ++ E+ G+ T ++APE+ + + ++ D++ +++ Sbjct: 188 VFDRASGEPVVIDLGLHSRSGEQPKGF--TESFKAPELGVGNLGASEKSDVF---LVVST 242 Query: 216 LLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFR 275 LL G F I + L I+SE A ++ P+ + ++ + Sbjct: 243 LLHGIEGFEKDPEIK------------PNQGLRFITSEPAHVMDENGYPIHRPGIAGVET 290 Query: 276 GANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPED 316 D+LG + +D R + EA H + S E+ Sbjct: 291 AYTRFITDILG----VSADSRPDSNEARLHEFLSDGTIDEE 327 >6EQI-C nrPDB Length = 433 Score = 101 bits (253), Expect = 4e-22, Method: Composition-based stats. Identities = 61/348 (17%), Positives = 105/348 (30%), Gaps = 100/348 (28%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDA-----RLRQKVAVKKL---SRPFQSLIHARRTYRE-- 71 L P+ G V SA +L ++AVK + S + YRE Sbjct: 15 DELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETV 74 Query: 72 -------------LRLLKHLK-----HENVIGLLDVF---------------------TP 92 + + K H N++ + VF Sbjct: 75 PAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRIN 134 Query: 93 ATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLK 152 ++LV L ++ + + L+ QLL + +++ I HRDLK Sbjct: 135 PEGSGRNMSLFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQLLEAVAHMNIHNISHRDLK 194 Query: 153 PSNVAVNED-----CELRILDF---------GLARQADEEMTGYVATRWYRAPEIM---- 194 N+ V+ + I DF GL E R APEI Sbjct: 195 SDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIANAKP 254 Query: 195 --LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 252 +W++Y + D+W+VG I E+ F Sbjct: 255 GTFSWLNY-KKSDLWAVGAIAYEIFNIDNPF----------------------------- 284 Query: 253 EHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 300 + +T ++DL + + +L+ ML +++R+ Sbjct: 285 -YDKTMKLLSKSYKEEDLPELPDTIPFIIRNLVSNMLSRSTNKRLDCD 331 >5UV4-A nrPDB Length = 311 Score = 100 bits (250), Expect = 7e-22, Method: Composition-based stats. Identities = 42/206 (20%), Positives = 75/206 (36%), Gaps = 19/206 (9%) Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87 +G +G+ A + VK L F + RE++ L ++H N++ L Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAK--SKKEFSREIKKLGSVRHPNLVPLR 87 Query: 88 DVFTPATSIEDFSEVYLVTTLMGADLNNIVKC------QALSDEHVQFLVYQLLRGLKYI 141 + ++ + + L+ + LS + + R L Y+ Sbjct: 88 GYYWGP---KEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYL 144 Query: 142 HSAGII-HRDLKPSNVAV-NEDCELRILDFGLARQADE----EMTGYVATRWYRAPEIML 195 H+ +I H ++K SNV + N + D+ L R E Y PE Sbjct: 145 HNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSS 204 Query: 196 NWMHY-NQTVDIWSVGCIMAELLQGK 220 + D+++ G I+ ELL GK Sbjct: 205 TSKPCPSLKSDVYAFGVILLELLTGK 230 >4IX6-A nrPDB Length = 350 Score = 97.3 bits (241), Expect = 1e-20, Method: Composition-based stats. Identities = 66/343 (19%), Positives = 115/343 (33%), Gaps = 75/343 (21%) Query: 21 PQRLQGL-RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR-ELRLLKHL 78 P+ ++ L P+GSG +G+V + V L ++ A E+ + H+ Sbjct: 18 PKDIRVLPGPLGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAEELLECEMDVNYHV 73 Query: 79 KHEN----VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNN----------IVKCQALSD 124 H N + +D E+Y T G L +++ Sbjct: 74 -HANAKGTCARFMGCIELGA--KDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPL 130 Query: 125 EHV------------QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED--CELRILDFG 170 + + +LL L +H G++HRD+KP+N+ E L+++D G Sbjct: 131 ATAMACADATELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLG 190 Query: 171 ---LARQADEEMTGYVAT-----RWYRAPEIMLNWMHYNQTV----------------DI 206 L E + Y R+ +A E+ L + D Sbjct: 191 AAALCLPLPETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDS 250 Query: 207 WSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP 266 WS GC+M +L +++ + VG + S E+ +L Sbjct: 251 WSAGCVMLQLAV--VGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALDANG 308 Query: 267 QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309 DL R++ + D R S AL+HA+F Sbjct: 309 GAGW------------DLCQRLMEAERDARASCEAALSHAFFD 339 >4I94-A nrPDB Length = 300 Score = 96.9 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 50/256 (19%), Positives = 98/256 (38%), Gaps = 18/256 (7%) Query: 37 SVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSI 96 V ++++AVK+ +R +S +R+ E + + L++ + LL Sbjct: 44 VVYKG-KLENQRRIAVKRFNR--KSWPDSRQFLEEAKAVGQLRNHRMANLLGCCY----- 95 Query: 97 EDFSEVYLVTTLMGADLNNIV---KCQALSDEHVQFLVYQLLRGLKYIHSAG-IIHRDLK 152 ED + + + L + + Q + + + + L+Y S G ++ DL Sbjct: 96 EDEERLLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLN 155 Query: 153 PSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCI 212 V ++D R+ FGL + + + Y + PE + ++V I+S G + Sbjct: 156 AYRVLFDDDANPRLSCFGLMKNSRDG-KSYSTNLAFTPPEYLRTGRVTPESV-IYSFGTL 213 Query: 213 MAELLQGK--ALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLP--PMPQK 268 + +LL GK D I M + + + +E R + L P + Sbjct: 214 LLDLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRERP 273 Query: 269 DLSSIFRGANPLAIDL 284 + S+ PL DL Sbjct: 274 NPKSLVSAMIPLQKDL 289 >5C01-A nrPDB Length = 342 Score = 94.2 bits (233), Expect = 7e-20, Method: Composition-based stats. Identities = 44/278 (15%), Positives = 85/278 (30%), Gaps = 57/278 (20%) Query: 41 AYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFS 100 D +V +K L + A Y L+ + H ++ + V Sbjct: 101 GRDRGQELRVVLKVLDPSHHDIALA--FYETASLMSQVSHTHLAFVHGVCVRGP------ 152 Query: 101 EVYLVTTLM-GADLNNIVKCQA--LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVA 157 E +VT + L+ ++ + + + QL L Y+ + ++H ++ N+ Sbjct: 153 ENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 212 Query: 158 VNEDCE-------LRILD--FGLARQADEEMTGYVATRWYRAPEIMLNW-MHYNQTVDIW 207 + +++ D GL + EE + + APE + + +D W Sbjct: 213 LARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLSTAMDKW 269 Query: 208 SVGCIMAEL-LQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP 266 G + E+ G+A L S + Q +P Sbjct: 270 GFGATLLEICFDGEAP------------------------LQSRSPSEKEHFYQRQHRLP 305 Query: 267 QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 + P L + L + QR S L Sbjct: 306 EPSC--------PQLATLTSQCLTYEPTQRPSFRTILR 335 >4WOV-A nrPDB Length = 317 Score = 93.8 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 44/278 (15%), Positives = 85/278 (30%), Gaps = 57/278 (20%) Query: 41 AYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFS 100 D +V +K L + A Y L+ + H ++ + V Sbjct: 78 GRDRGQELRVVLKVLDPSHHDIALA--FYETASLMSQVSHTHLAFVHGVCVRGP------ 129 Query: 101 EVYLVTTLM-GADLNNIVKCQA--LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVA 157 E +VT + L+ ++ + + + QL L Y+ + ++H ++ N+ Sbjct: 130 ENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 189 Query: 158 VNEDCE-------LRILD--FGLARQADEEMTGYVATRWYRAPEIMLNW-MHYNQTVDIW 207 + +++ D GL + EE + + APE + + +D W Sbjct: 190 LARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLSTAMDKW 246 Query: 208 SVGCIMAEL-LQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP 266 G + E+ G+A L S + Q +P Sbjct: 247 GFGATLLEICFDGEAP------------------------LQSRSPSEKEHFYQRQHRLP 282 Query: 267 QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 + P L + L + QR S L Sbjct: 283 EPSC--------PQLATLTSQCLTYEPTQRPSFRTILR 312 >6J6I-B nrPDB Length = 351 Score = 87.3 bits (215), Expect = 9e-18, Method: Composition-based stats. Identities = 35/193 (18%), Positives = 69/193 (35%), Gaps = 25/193 (12%) Query: 47 RQKVAVKKLSRPF--QSLIHARRTYRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVY 103 + +K+ S + Y ++ L + H N + LL +F Sbjct: 81 DRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCL------EFPFPV 134 Query: 104 LVTTLMGADLNN-----IVKCQA--LSDEHVQFLVYQLLRGLKYIHS---AGIIHRDLKP 153 LV N IV + L + ++ + Y+H+ IIHRD+KP Sbjct: 135 LVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKP 194 Query: 154 SNVAVNEDCELRILDFGLARQADEEMTG-----YVATRWYRAPEIMLNWMHYNQTVDIWS 208 +V ++++ ++ D + E + + T Y P + + D++S Sbjct: 195 MHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYS 253 Query: 209 VGCIMAELLQGKA 221 G + ++ GK Sbjct: 254 FGICLLVIITGKP 266 >5UU1-A nrPDB Length = 324 Score = 86.5 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 43/228 (18%), Positives = 85/228 (37%), Gaps = 36/228 (15%) Query: 26 GLRPVGSGAYGSVCSAYDARLRQKVA---VKKLSRPFQSLIHARRTYRELRLLKHLKHEN 82 + +GSG +G + A+ +K A VK + EL+ + + ++ Sbjct: 20 LGKKIGSGGFGLIYLAFPTNKPEKDARHVVKV------EYQENGPLFSELKFYQRVAKKD 73 Query: 83 VIG---------LLDV--FTPATSIEDFSEVY--LVTTLMGADLNNIV-KCQALSDEHVQ 128 I L + F + E Y +V +G DL I + V Sbjct: 74 CIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVL 133 Query: 129 FLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN--EDCELRILDFGLA----------RQAD 176 L ++L L+YIH +H D+K +N+ + ++ + D+GL+ + + Sbjct: 134 QLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQE 193 Query: 177 EEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFP 224 G+ T + + + + ++ D+ +G M L GK + Sbjct: 194 NPRKGHNGTIEFTSLDAHKG-VALSRRSDVEILGYCMLRWLCGKLPWE 240 >2RSV-A nrPDB Length = 403 Score = 77.6 bits (190), Expect = 8e-15, Method: Composition-based stats. Identities = 53/291 (18%), Positives = 109/291 (37%), Gaps = 32/291 (10%) Query: 29 PVGSGAYGSVCSAYDARLRQKV------AVKKLSRP----FQSLIHARRTYRELRLLKHL 78 P+G G +G + A D + V VK F L +R + ++ K + Sbjct: 49 PIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWI 107 Query: 79 KHENVIGLLDVF-TPATSIEDFS---EVYLVTTLMGADLNNI--VKCQALSDEHVQFLVY 132 + + L V + + D + +++ G+DL I + S + V L Sbjct: 108 RTRK-LKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSL 166 Query: 133 QLLRGLKYIHSAGIIHRDLKPSNVAVN--EDCELRILDFGLA---------RQADEEMTG 181 ++L L+YIH +H D+K SN+ +N ++ ++D+GLA ++ E+ Sbjct: 167 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 226 Query: 182 -YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV-V 239 + T + + + ++ D+ +G M + L G + + + R ++ Sbjct: 227 CHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRY 285 Query: 240 GTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLV 290 ++ K E + + K L + D+L + L Sbjct: 286 RENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLK 336 >2LAV-A nrPDB Length = 361 Score = 76.5 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 53/291 (18%), Positives = 109/291 (37%), Gaps = 32/291 (10%) Query: 29 PVGSGAYGSVCSAYDARLRQKV------AVKKLSRP----FQSLIHARRTYRELRLLKHL 78 P+G G +G + A D + V VK F L +R + ++ K + Sbjct: 42 PIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWI 100 Query: 79 KHENVIGLLDVF-TPATSIEDFS---EVYLVTTLMGADLNNI--VKCQALSDEHVQFLVY 132 + + L V + + D + +++ G+DL I + S + V L Sbjct: 101 RTRK-LKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSL 159 Query: 133 QLLRGLKYIHSAGIIHRDLKPSNVAVN--EDCELRILDFGLA---------RQADEEMTG 181 ++L L+YIH +H D+K SN+ +N ++ ++D+GLA ++ E+ Sbjct: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 Query: 182 -YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV-V 239 + T + + + ++ D+ +G M + L G + + + R ++ Sbjct: 220 CHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRY 278 Query: 240 GTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLV 290 ++ K E + + K L + D+L + L Sbjct: 279 RENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLK 329 >5DMZ-A nrPDB Length = 365 Score = 71.1 bits (173), Expect = 7e-13, Method: Composition-based stats. Identities = 55/300 (18%), Positives = 100/300 (33%), Gaps = 43/300 (14%) Query: 15 KTVWEVPQRLQGLR-PVGSGAYGSVCSAY-----DARLRQKVAVKKLSRPFQSLIHARRT 68 KT +++ +L + +G GA+ V A DA+ +QK +K + Sbjct: 57 KTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQ 116 Query: 69 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVKCQALSDEHV 127 E RL ++H + E+Y TL+ A +L + + V Sbjct: 117 LME-RLKPSMQHMF-MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLV 174 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE-----------LRILDFGLARQA- 175 ++L ++ +H IIH D+KP N + L ++D G + Sbjct: 175 ISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMK 234 Query: 176 ----DEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQ 231 T T ++ E++ N +N +D + V + +L G Sbjct: 235 LFPKGTIFTAKCETSGFQCVEMLSN-KPWNYQIDYFGVAATVYCMLFG-----------T 282 Query: 232 LKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVL 291 ++ G PE L + H + + M +DLL + L Sbjct: 283 YMKVKNEGGECKPEGLFRRLP-HLDMWNEFFHVMLNIPDCHHLPS-----LDLLRQKLKK 336 >6G4J-A nrPDB Length = 315 Score = 68.8 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 48/232 (20%), Positives = 79/232 (34%), Gaps = 41/232 (17%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 83 + +G GA G V A VA+K + E+ +LK Sbjct: 28 YTLRKQLGKGANGIVYLAE--TSDGHVALKV-------SDDSLSITSEVNVLKSFSKA-- 76 Query: 84 IGLLDVFTPATSIEDFSEVYL-----------VTTLMGADLNNIVKCQALSDEHVQFLVY 132 T S D + Y+ + + G L V + E + L+ Sbjct: 77 ----QSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKG--AEWIPVLMI 130 Query: 133 QLLRGLKYIHSAGIIHRDLKPSN-VAVNEDCELRILDFGLARQADEEMTGYVATRWYRAP 191 QLL L +H G I DLKP N + +R +D G + + Y T +Y Sbjct: 131 QLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEY--TEFY--- 185 Query: 192 EIMLNWMHYNQ-----TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 238 + Y + D+++V IM + K + +QL+ ++E Sbjct: 186 --DRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSLIEG 235 >4O1O-A nrPDB Length = 717 Score = 66.9 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 44/275 (16%), Positives = 93/275 (33%), Gaps = 82/275 (29%) Query: 47 RQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK-HENVIGLLDVFTPATSIEDFSEVYLV 105 Q+VAVK+ S R +E+ L+ + ++NV+ S D S +++ Sbjct: 369 DQEVAVKRFSEGST------RGQQEVSCLQSSRANDNVVTFYG------SESDGSCLHVC 416 Query: 106 TTLMGADLNNIVKCQALS------DEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN 159 L L + DE + ++ L + + +H +G H+DL+P N+ ++ Sbjct: 417 LALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILID 476 Query: 160 EDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVG-CIMAELLQ 218 + DF + + E+ D+ ++G ++ + + Sbjct: 477 SKNGTFLADFDKSIKWAEDPQK--------------------IKRDLEALGLLVLYVVKK 516 Query: 219 GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGAN 278 G F + +++ G+P E Sbjct: 517 GDISFETLKNQS-FEEVIQ--GSPDEET-------------------------------- 541 Query: 279 PLAIDLLGRMLVL--DSDQRVSAAEALAHAYFSQY 311 DL+ + + + R+S+ LAH +F + Sbjct: 542 ---RDLIHHLFHPGDNVEDRLSS--LLAHPFFWSW 571 >4OAU-C nrPDB Length = 699 Score = 64.5 bits (156), Expect = 7e-11, Method: Composition-based stats. Identities = 29/169 (17%), Positives = 66/169 (39%), Gaps = 26/169 (15%) Query: 9 YRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT 68 YR + K + + ++ + + G + + + Q+VAVK + R Sbjct: 334 YRPMIGKLKFFIDEKYKIADT----SEGGIYLGFYEK--QEVAVKTFCEG------SPRA 381 Query: 69 YRELRLLKHLK-HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQA------ 121 RE+ L+ + + +++ S +++ TL L + Sbjct: 382 QREVSCLQSSRENSHLVTFYG------SESHRGHLFVCVTLCEQTLEACLDVHRGEDVEN 435 Query: 122 LSDEHVQFLVYQLLRGLKYIH-SAGIIHRDLKPSNVAVNEDCELRILDF 169 DE + ++ + + ++ +H S G H+DL+P N+ ++ + DF Sbjct: 436 EEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 484 >6M7Z-A nrPDB Length = 319 Score = 62.6 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 37/236 (15%), Positives = 81/236 (34%), Gaps = 59/236 (25%) Query: 103 YLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDC 162 Y+ L + ++++ S VQ L ++ LK +H+ G++HR ++ ++ +V D Sbjct: 123 YIFHPLSKGLVGDMLETGR-SHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDG 181 Query: 163 ELRILDFGLARQADEEMT---GYVATRWYRAPEI--------MLNWMHYNQTVDIWSVGC 211 + + A E G+ APEI L + D++S+G Sbjct: 182 TVVLGGLDTAAPIGTETRLWVGFFGQE--TAPEIDRNFLADLALTQGRHTVKSDVYSLGV 239 Query: 212 IMAELLQGKALFPGSDYIDQLKRIMEVVGTPS--PEVLAKISSEHARTYIQSLPPMPQKD 269 + +++++G + PE + +H + Sbjct: 240 -------------------AFRNLVQLLGNGNLGPEDRGAVRQDHLELLDK--------- 271 Query: 270 LSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPE-DEPEAEPYD 324 L +M+ + R + E + F + + +E +A P+ Sbjct: 272 --------------LSQKMIEEEPGNRPTIEEIMKDPLFEGLNFEDIEEGKARPFR 313 >2JII-A nrPDB Length = 352 Score = 62.2 bits (150), Expect = 4e-10, Method: Composition-based stats. Identities = 30/165 (18%), Positives = 64/165 (38%), Gaps = 16/165 (9%) Query: 96 IEDFSEVYLVTTLMGADLN---NIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLK 152 + +LV +G L ++ LS+ V + +LL L+++H +H ++ Sbjct: 127 VHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVT 186 Query: 153 PSNVAVN--EDCELRILDFGLARQADEEMTGYVATRWYRAP-----EIML----NWMHYN 201 N+ V+ + ++ + +G A + R+P E + + Sbjct: 187 AENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPS 246 Query: 202 QTVDIWSVGCIMAELLQGKALFPGS--DYIDQLKRIMEVVGTPSP 244 + D+ S+G M + L G + + D +K+ + V P P Sbjct: 247 RRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGP 291 >6EWX-A nrPDB Length = 484 Score = 60.7 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 47/224 (20%), Positives = 71/224 (31%), Gaps = 74/224 (33%) Query: 124 DEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDC--------------------- 162 + V FL+ QL GL+++ GIIHRDL N+ + Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCP 268 Query: 163 --------------------ELRILDFGLARQADEEMTGYVATR--WYRAPEIMLNWMHY 200 L I +F A+Q T + APEI+ + Sbjct: 269 SAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQY- 327 Query: 201 NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQ 260 + D + G ++ ELL F EV A++ R + Sbjct: 328 -RKFDEFQTGILIYELLHQPNPF---------------------EVRAQLRERDYRR--E 363 Query: 261 SLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 LPP+P L +P L +L D +R+ EA Sbjct: 364 DLPPLPTLSL------YSPGLQQLAHLLLEADPIKRIRIGEAKR 401 >3ENH-A nrPDB Length = 540 Score = 59.9 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 39/180 (21%), Positives = 71/180 (39%), Gaps = 36/180 (20%) Query: 9 YRQELNKTVW---------EVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVK-KLSRP 58 YR ++ + W ++P+ L +G GA + D+ L V +K ++ + Sbjct: 319 YRTDMVEVNWIKEIKGKKRKIPEHL-----IGKGAEADIK--RDSYLDFDVIIKERVKKG 371 Query: 59 FQSL-----IHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADL 113 ++ I RT RE R L ++ + P D ++ + + L Sbjct: 372 YRDERLDENIRKSRTAREARYLA------LVKDFGIPAPYIFDVDLDNKRIMMSYINGKL 425 Query: 114 NNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR 173 V L + Y++ + +H +IH DL SN ++D L I+DFGL + Sbjct: 426 AKDVIEDNLD------IAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGK 477 >6EAS-A nrPDB Length = 308 Score = 56.1 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 36/250 (14%), Positives = 74/250 (29%), Gaps = 42/250 (16%) Query: 61 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK-- 118 S + + +++ L + H+N + LL F+ V + L + Sbjct: 81 SKENESQYRKKITNLSKVSHKNFMNLLGYCEEEHP---FTRVMVFEYAPNGTLFEHLHVR 137 Query: 119 -CQALSDEHVQFLVYQLLRGLKYIHSAGI--IHRDLKPSNVAVNEDCELRILDFGL---A 172 + L + + L+++H R+ + V + +D ++ D A Sbjct: 138 EAEKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDLEFWNDA 197 Query: 173 RQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQL 232 + + +A +P++ Y G ++ E+L G+ D + Sbjct: 198 KGHNSTTNNELA----FSPDMEDIVRKY---------GMVLLEILTGRVPSSEDDGPLEN 244 Query: 233 KRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLD 292 G E L S I P + L + R + D Sbjct: 245 WVSRYFEGGMRLEELIDPS-------IGFFPEDTARALCEVVRS-----------CIDRD 286 Query: 293 SDQRVSAAEA 302 +R E Sbjct: 287 PKKRPQMKEV 296 >6G38-A nrPDB Length = 357 Score = 55.7 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 37/204 (18%), Positives = 63/204 (30%), Gaps = 54/204 (26%) Query: 4 PRAGFYRQELNKTVWEVP---------QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKK 54 Y Q + + + P ++LQ +G G +G V VA+K Sbjct: 14 GTENLYFQSMGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHT--PVAIKI 71 Query: 55 L------------SRPFQSLIHARRTYRELRLLK-----------HLKHENVIG------ 85 + + F+ ++ +EL LL L + + Sbjct: 72 IAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPL 131 Query: 86 LLDVF------------TPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQ 133 LL + P +D + L G DL ++ + S + +++Q Sbjct: 132 LLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQ-MRTKLSSLATAKSILHQ 190 Query: 134 LLRGLKYIH-SAGIIHRDLKPSNV 156 L L S HRDL NV Sbjct: 191 LTASLAVAEASLRFEHRDLHWGNV 214 >4AZW-A nrPDB Length = 471 Score = 54.9 bits (131), Expect = 5e-08, Method: Composition-based stats. Identities = 25/121 (20%), Positives = 48/121 (39%), Gaps = 16/121 (13%) Query: 55 LSRPFQSLIHARRTYRELRLLKH----LKHENVIGLLDVFTPATSIEDFSEVYLVTT-LM 109 + +S + + E++ L V+ E+ +LV L Sbjct: 275 ILTAEESQRNKHELHNEIKFLTQPPAGFDAPAVL---------AHGENAQSGWLVMEKLP 325 Query: 110 GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDF 169 G L++++ + + ++ LLR L + G H D++P NV V+ R++DF Sbjct: 326 GRLLSDMLAAG--EEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDF 383 Query: 170 G 170 G Sbjct: 384 G 384 >6BHC-A nrPDB Length = 438 Score = 54.1 bits (129), Expect = 8e-08, Method: Composition-based stats. Identities = 46/296 (15%), Positives = 86/296 (29%), Gaps = 78/296 (26%) Query: 50 VAVKKLSRPFQSLIH-------ARRTYRELRLLKHLKH-----ENVIGLLDVFTPATS-- 95 AVK + + + + H N LL P+ Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPN--RLLPWEDPSKKQR 143 Query: 96 -----IEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRD 150 I V + L K L + V L+ QL GL+++ + H D Sbjct: 144 SHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCD 203 Query: 151 LKPSNVAVNE---------------------DCELRILDFGLARQADEEMTGYV---ATR 186 L+ N+ + L + +F A+Q + + +R Sbjct: 204 LRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSR 263 Query: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEV 246 APEI+ + + D + G ++ E+L F +PE+ Sbjct: 264 --LAPEIITATQY--KKCDEFQTGILIYEMLHLPNPF-----------------DENPEL 302 Query: 247 LAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEA 302 + LP +P + + L +L + +R+ ++A Sbjct: 303 ------KEREYTRADLPRIPFRS------PYSRGLQQLASCLLNPNPSERILISDA 346 >4CYJ-A nrPDB Length = 438 Score = 54.1 bits (129), Expect = 9e-08, Method: Composition-based stats. Identities = 25/144 (17%), Positives = 59/144 (40%), Gaps = 20/144 (13%) Query: 38 VCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIE 97 V A ++R + A+++L L + + ++ K +K+ +++ + +VFT Sbjct: 71 VYKAQNSRNGRHYALRRL--EGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFTTR---- 124 Query: 98 DFSEVYLVTTLMGADLNNIVKCQAL--------------SDEHVQFLVYQLLRGLKYIHS 143 +F + L+ L+ ++ + + + Q+ LK IHS Sbjct: 125 EFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHS 184 Query: 144 AGIIHRDLKPSNVAVNEDCELRIL 167 + R L+PS + + + +R+ Sbjct: 185 NRLAARCLEPSKIILTDINRIRLS 208 >4AZV-A nrPDB Length = 569 Score = 54.1 bits (129), Expect = 9e-08, Method: Composition-based stats. Identities = 25/121 (20%), Positives = 48/121 (39%), Gaps = 16/121 (13%) Query: 55 LSRPFQSLIHARRTYRELRLLKH----LKHENVIGLLDVFTPATSIEDFSEVYLVTT-LM 109 + +S + + E++ L V+ E+ +LV L Sbjct: 275 ILTAEESQRNKYELHNEIKFLTQPPAGFDAPAVL---------AHGENAQSGWLVMEKLP 325 Query: 110 GADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDF 169 G L++++ + + ++ LLR L + G H D++P NV V+ R++DF Sbjct: 326 GRLLSDMLAAG--EEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVDARQHARLIDF 383 Query: 170 G 170 G Sbjct: 384 G 384 >5GZA-A nrPDB Length = 290 Score = 53.0 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 49/222 (22%), Positives = 78/222 (35%), Gaps = 48/222 (21%) Query: 19 EVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL 78 E+ ++ ++ +G GA V + QKVA+ LS S +A L +L+ L Sbjct: 22 EIRSGVRRVKLIGQGAVKKVYLSEWQ--GQKVALSVLS----SDQYADDFLHGLSMLRAL 75 Query: 79 KHENVIGLLDVFTP-ATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRG 137 + +V+ L+ V A + ++ + V TL L S L + Sbjct: 76 QSSHVVTLVGVCEEDAVFVTEYHPLGSVLTL-DTTLAQERYRWRNSWHTRLQLAIDYVAF 134 Query: 138 LKYIHS--AGI--------IHRDLKPSNVAVNEDCELRILDFGLARQAD-------EEMT 180 L Y+HS AGI +H+ L S + D L LA D + Sbjct: 135 LAYLHSSPAGIRVMCDSNDLHKTL--SQFLLASDMRL------LANDLDALPEVEKGGLG 186 Query: 181 GYVA----TRWYRAPEIM-----------LNWMHYNQTVDIW 207 T + APE + Y++ DIW Sbjct: 187 VKCGHHELTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >5VE6-A nrPDB Length = 492 Score = 51.4 bits (122), Expect = 6e-07, Method: Composition-based stats. Identities = 15/35 (42%), Positives = 22/35 (62%) Query: 124 DEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAV 158 + V FL+ QL GL+++ GIIHRDL N+ + Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 Score = 38.4 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 26/116 (22%), Positives = 40/116 (34%), Gaps = 31/116 (26%) Query: 189 RAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLA 248 APEI+ + + D + G ++ ELL F EV A Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELLHQPNPF---------------------EVRA 361 Query: 249 KISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304 ++ R + LPP+P L +P L +L D +R+ EA Sbjct: 362 QLRERDYRQ--EDLPPLPALSL------YSPGLQQLAHLLLEADPIKRIRIGEAKR 409 >4WWA-A nrPDB Length = 261 Score = 50.3 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 37/172 (21%), Positives = 57/172 (33%), Gaps = 36/172 (20%) Query: 29 PVGSGAYGSV-------CSAYDARLRQKVAVKKLSRPFQSLIHAR--------RTYRELR 73 P+ GA V QK +K RP + H + RT E R Sbjct: 21 PISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKY--RPPKRYRHPQIDQALTKHRTLNESR 78 Query: 74 LLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADL-----------NNIVKCQAL 122 LL L +I + P D ++ +G DL + Q Sbjct: 79 LLAKL---YLIP--GLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDP 133 Query: 123 SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDC---ELRILDFGL 171 + V + ++ R + +H H DL SN+ + D ++DFGL Sbjct: 134 YSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >5GZ9-A nrPDB Length = 305 Score = 49.9 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 43/215 (20%), Positives = 79/215 (36%), Gaps = 49/215 (22%) Query: 27 LRPVGSGAYGSVCSAYDARLRQ-KVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIG 85 L+ VG GA V + + ++ KVA+ +L+R L L++LK L+ E+V+ Sbjct: 39 LKRVGEGA---VKRVFLSEWKEHKVALSRLTR----LEMKEDFLHGLQMLKSLQSEHVVT 91 Query: 86 LLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKCQALSD-EHVQFLVYQLLRGLKYIHS 143 L+ + ++T L+N+ + LS + V ++L ++Y+ Sbjct: 92 LVGYCEEDGT--------ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSI 143 Query: 144 AGIIH------RDLKPSN--------VAVNEDCELRILDFGLARQADEEMTG--YVATRW 187 +H R + SN + + + D D + R Sbjct: 144 INYLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRE 203 Query: 188 ----YRAPEIMLNWM-----------HYNQTVDIW 207 + APE + + YN+ VDIW Sbjct: 204 LHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >3BYV-A nrPDB Length = 377 Score = 46.4 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 22/125 (17%), Positives = 46/125 (36%), Gaps = 14/125 (11%) Query: 110 GADLNNIVKCQALSDEHVQF-LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILD 168 G L + H + L Q++R L +H G++H L+P ++ +++ + + Sbjct: 190 GEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTG 249 Query: 169 F-GLARQADEEMTGYVATRWYRAPEIMLNWMHY----------NQTVDIWSVGCIMAELL 217 F L R D +R + PE+ + D W++G ++ + Sbjct: 250 FEHLVR--DGARVVSSVSRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIW 307 Query: 218 QGKAL 222 Sbjct: 308 CADLP 312 >4BWP-A nrPDB Length = 448 Score = 46.1 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 31/167 (18%), Positives = 49/167 (29%), Gaps = 42/167 (25%) Query: 39 CSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIED 98 A K L R + + + + + K L+H NV+ L +VFT Sbjct: 67 YRATHNTTGYKY---CLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAF--G 121 Query: 99 FSEVYLVTTLMGAD---LNNIV------------------------------KCQALSDE 125 + + LV L L + Sbjct: 122 DNSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEA 181 Query: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED----CELRILD 168 + ++ QL GLK IH AG+ + L P+ + V I D Sbjct: 182 TIWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >3Q60-A nrPDB Length = 371 Score = 44.9 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 48/323 (14%), Positives = 95/323 (29%), Gaps = 52/323 (16%) Query: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYREL-----RLLK 76 ++L+ + P+ G V D + A+K + ++ E RLL Sbjct: 62 RKLKLVEPLRVGDRSVVFLVRDVERLEDFALKVFTMGAENSRSELERLHEATFAAARLLG 121 Query: 77 H------------LKHENV-IGLLDVFTPATSIEDF----SEVYLV------TTLMGADL 113 L + V + F + +D + + L+ L+ + L Sbjct: 122 ESPEEARDRRRLLLPSDAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAASVDLELLFSTL 181 Query: 114 NNIVKCQALSDEHVQFLV-YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLA 172 + + + ++ QL+R + S G++H P N+ + D L + D Sbjct: 182 DFVYVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGDVSAL 241 Query: 173 RQADEEMTGYVATRWYRAPEIM-LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQ 231 + Y E + + + ++ W +G + + F Sbjct: 242 WKVGTRGPASSVPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPF-------- 293 Query: 232 LKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVL 291 G +P + R P L+GR L Sbjct: 294 --------GLVTPGIKGSWKRPSLRV------PGTDSLAFGSCTPLPDFVKTLIGRFLNF 339 Query: 292 DSDQRVSAAEALAHAYFSQYHDP 314 D +R+ EA+ F Q + Sbjct: 340 DRRRRLLPLEAMETPEFLQLQNE 362 >2W1Z-A nrPDB Length = 368 Score = 42.6 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 39/263 (14%), Positives = 81/263 (30%), Gaps = 55/263 (20%) Query: 13 LNKTVWEVPQRLQGLRPVGS--------------GAYGSVCSAYDARLRQ--KV------ 50 ++ +W Q + +G G+Y A D + +V Sbjct: 36 VSTALWRNEQSFRVESELGERPRTLVRGPVLRDDGSY-ICLEATDQETGEPLEVHVPYFT 94 Query: 51 ------AVKKLS---------RPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATS 95 A+K+LS R ++ A+ R + + +K ++ V Sbjct: 95 ERPPSNAIKQLSEQVLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERD 154 Query: 96 IEDFSEVYLV------TTLMGADLNNIVKCQALSDEHVQF-LVYQLLRGLKYIHSAGIIH 148 + S +L ++G L + H + L QL+R + G++H Sbjct: 155 MWVLSRFFLYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVH 214 Query: 149 RDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWM-HY------- 200 D + N+ +++ + + F + + R + PE M Y Sbjct: 215 ADFQVRNILLDQRGGVFLTGFEHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTL 273 Query: 201 -NQTVDIWSVGCIMAELLQGKAL 222 D W++G + + Sbjct: 274 MTFPFDTWTLGLAIYWIWCADLP 296 >3DZO-A nrPDB Length = 413 Score = 41.8 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 20/123 (16%), Positives = 42/123 (34%), Gaps = 11/123 (8%) Query: 110 GADLNNIVKCQALSDEHVQF-LVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILD 168 G L + H + L Q++R L +H G++H L+P ++ +++ + + Sbjct: 195 GEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTG 254 Query: 169 FGLARQADEEMTGYVATRWYRAPEIMLNWM---------HYNQTVDIWSVGCIMAELLQG 219 F + + R + PE M D W++G + + Sbjct: 255 FEHLVRDGASAVSPIG-RGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCA 313 Query: 220 KAL 222 Sbjct: 314 DLP 316 >1TQM-A nrPDB Length = 282 Score = 41.8 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 33/168 (19%), Positives = 65/168 (38%), Gaps = 31/168 (18%) Query: 26 GLRPVGSGAYGSVCSAYDARLRQKVAV---------KKLSRPFQ------SLIHARRTYR 70 + +G G +V + Y + + V KK+ S++ R Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 71 ELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFL 130 E R L+ L+ + P + + V + L+ D + + + + + V + Sbjct: 154 EFRALQKLQ--------GLAVPKVYAWEGNAV--LMELI--DAKELYRVRVENPDEVLDM 201 Query: 131 VYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE 178 +L + + GI+H DL NV V+E+ + I+DF + + EE Sbjct: 202 ---ILEEVAKFYHRGIVHGDLSQYNVLVSEEG-IWIIDFPQSVEVGEE 245 >6R5K-O nrPDB Length = 689 Score = 41.4 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 24/139 (17%), Positives = 48/139 (34%), Gaps = 14/139 (10%) Query: 37 SVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSI 96 V S YD + +K+L +S+ + + + ++ + N+I D+F Sbjct: 312 KVFSNYD---GKAYVLKRLPNIDKSM-NPNKISKIYQIWSKINCTNLIKFRDIFQTTKF- 366 Query: 97 EDFSEVYLVTTLMGADL----NNIVKCQALSD--EHVQFLVYQLLRGLKYIHSAGI-IHR 149 + LV L + V ++ + QL + IHS + I Sbjct: 367 -GDLSICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGN 425 Query: 150 DLKPSNVAVNED-CELRIL 167 L V + D +++ Sbjct: 426 TLNWRKVLITGDPGRIKLS 444 >4XR7-L nrPDB Length = 465 Score = 39.9 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 24/139 (17%), Positives = 48/139 (34%), Gaps = 14/139 (10%) Query: 37 SVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSI 96 V S YD + +K+L +S+ + + + ++ + N+I D+F Sbjct: 88 KVFSNYD---GKAYVLKRLPNIDKSM-NPNKISKIYQIWSKINCTNLIKFRDIFQTTKF- 142 Query: 97 EDFSEVYLVTTLMGADL----NNIVKCQALSD--EHVQFLVYQLLRGLKYIHSAGI-IHR 149 + LV L + V ++ + QL + IHS + I Sbjct: 143 -GDLSICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGN 201 Query: 150 DLKPSNVAVNED-CELRIL 167 L V + D +++ Sbjct: 202 TLNWRKVLITGDPGRIKLS 220 >5YK0-A nrPDB Length = 452 Score = 39.1 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 29/176 (16%), Positives = 50/176 (28%), Gaps = 51/176 (28%) Query: 36 GSVCSAYDARLRQKVAVKKLSRPFQSLIHA--RRTYRELRLLKHL--------------- 78 G V A ++VAVK + A + R + +LK L Sbjct: 146 GQVHKAI-WSDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 79 -----------------------KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNN 115 H F + +V + + G + Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPR-------FQVPHVVASAPKVVIQEWIEGVPMAE 257 Query: 116 IVKCQALSDEH-VQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFG 170 I++ + L+ +L G++H D P N + D + I+DFG Sbjct: 258 IIRHGTTEQRDLIGTLLAELT--FDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFG 311 >4CZY-B nrPDB Length = 429 Score = 38.7 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 21/146 (14%), Positives = 51/146 (34%), Gaps = 26/146 (17%) Query: 39 CSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLL------KHLKHENVIGLLDVFTP 92 A + + + A++++ R E +L K + + N++ + + FT Sbjct: 61 YKAQNNKNGRHFALRRI--------EGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTT 112 Query: 93 ATSIEDFSEVYLVTTLMGADLNN-----------IVKCQALSDEHVQFLVYQLLRGLKYI 141 + + L + + + + + V Q+ L I Sbjct: 113 EFFGDSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAI 172 Query: 142 HSAGIIHRDLKPSNVAVNEDCELRIL 167 H+A + R L+ S + + E+ +R+ Sbjct: 173 HNAKLAARCLELSKI-IWENNRIRLA 197 >6G18-v nrPDB Length = 552 Score = 37.6 bits (86), Expect = 0.010, Method: Composition-based stats. Identities = 18/102 (17%), Positives = 38/102 (37%), Gaps = 12/102 (11%) Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127 +E +K L + P D++ +V L+ CQ E Sbjct: 158 AMKEFAYMK--------ALYERKFPVPKPIDYNRHAVVMELING----YPLCQIHHVEDP 205 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDF 169 + + + + + + G+IH D N+ ++E + ++DF Sbjct: 206 ASVYDEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 36.4 bits (83), Expect = 0.017, Method: Composition-based stats. Identities = 18/102 (17%), Positives = 38/102 (37%), Gaps = 12/102 (11%) Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127 +E +K L + P D++ +V L+ CQ E Sbjct: 158 AMKEFAYMK--------ALYERKFPVPKPIDYNRHAVVMELING----YPLCQIHHVEDP 205 Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDF 169 + + + + + + G+IH D N+ ++E + ++DF Sbjct: 206 ASVYDEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDF 247 >4ESA-B nrPDB Length = 146 Score = 34.1 bits (77), Expect = 0.097, Method: Composition-based stats. Identities = 14/51 (27%), Positives = 26/51 (50%), Gaps = 6/51 (11%) Query: 33 GAYGSVCSAYDARLRQKVA---VKK---LSRPFQSLIHARRTYRELRLLKH 77 G++G++ +A QKVA +K L R +++ + + Y EL +L Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEIYAELSILHS 93 >4UP8-A nrPDB Length = 777 Score = 32.2 bits (72), Expect = 0.33, Method: Composition-based stats. Identities = 19/101 (18%), Positives = 39/101 (38%), Gaps = 6/101 (5%) Query: 227 DYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLL- 285 + + +K + + P P S+E ++ + + + + L D + Sbjct: 318 NNEEDIKMLEKFFKEPIPRPFN--SAECSKVIEKHCTELNYYYDGNNEKAMKKLFADFVT 375 Query: 286 GRMLVLD---SDQRVSAAEALAHAYFSQYHDPEDEPEAEPY 323 + +VLD +R+S AL + + P D PEA + Sbjct: 376 EKKMVLDFTAPFKRISYVHALEEKFGEKIPRPLDGPEALTF 416 >6FAI-l nrPDB Length = 425 Score = 32.2 bits (72), Expect = 0.35, Method: Composition-based stats. Identities = 23/186 (12%), Positives = 52/186 (27%), Gaps = 40/186 (21%) Query: 24 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR---------------- 67 +G G + D +V +K S R Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Query: 68 -----TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQAL 122 +E + + L + F ++ + +V L+ ++ Sbjct: 154 LSRLAANKEYQFMSMLYSKG-------FKVPEPFDNSRHI-VVMELIEGYPMRRLRKHKN 205 Query: 123 SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNE------DCELRILDFGLARQAD 176 + L+ ++ + ++G+IH D N+ + + DC ++DF Sbjct: 206 IPKLYSDLMCFIVD----LANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQ 261 Query: 177 EEMTGY 182 + Y Sbjct: 262 HQDADY 267 >4BVU-A nrPDB Length = 211 Score = 32.2 bits (72), Expect = 0.37, Method: Composition-based stats. Identities = 23/148 (15%), Positives = 51/148 (34%), Gaps = 22/148 (14%) Query: 26 GLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIG 85 + +G G+ + + S ++ Y E+ + + E Sbjct: 44 LGKLIGQGSTAEIFEDVNDS----------SALYKKYDLIGNQYNEILEMAWQESE---- 89 Query: 86 LLDVFTPATS---IEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIH 142 L + F + I+ +VYL + + + + D + + + ++ Sbjct: 90 LFNAFYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICK----LN 145 Query: 143 SAGIIHRDLKPSNVAVNEDCE-LRILDF 169 IIH DL N+ +++ E L +DF Sbjct: 146 ELSIIHYDLNTGNMLYDKESESLFPIDF 173 >5N28-B nrPDB Length = 444 Score = 31.0 bits (69), Expect = 0.88, Method: Composition-based stats. Identities = 13/81 (16%), Positives = 31/81 (38%), Gaps = 3/81 (3%) Query: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALS---DEHVQFLVYQLLRGL 138 N+ LL T + +V + NI+ A + ++ F + + Sbjct: 174 NIASLLGAPTNLEGLGYALRNIMVNHYVATTKKNIMNAVAFASIMEQTAMFEMGDAIGSF 233 Query: 139 KYIHSAGIIHRDLKPSNVAVN 159 + +H G+ ++ L N+ ++ Sbjct: 234 ERLHLLGLAYQGLNADNLVID 254 >5LJ3-H nrPDB Length = 591 Score = 31.0 bits (69), Expect = 0.89, Method: Composition-based stats. Identities = 14/66 (21%), Positives = 30/66 (45%), Gaps = 6/66 (9%) Query: 114 NNIVKCQALSDEHVQFLVYQLLR--GLKYIHSAGIIHRDLKPSNVAVNEDCELR-ILDFG 170 + +K Q + E ++ V ++ + + + HRDL N+ + D + ++DF Sbjct: 8 DEDIKFQRENWEMIRSHVSPIISNLTMDNLQES---HRDLFQVNILIGRDIICKNVVDFT 64 Query: 171 LARQAD 176 L +Q Sbjct: 65 LNKQNG 70 >6BS5-B nrPDB Length = 394 Score = 31.0 bits (69), Expect = 0.90, Method: Composition-based stats. Identities = 15/69 (21%), Positives = 28/69 (40%), Gaps = 9/69 (13%) Query: 289 LVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQE-VLS 347 L +D +R+ A+AL +D + P+ P V + + T+ E V+ Sbjct: 53 LTIDPAKRL--AQALG------INDLGNTPQRVPLAPEVPGELHAMMLDMRRTFDEMVMQ 104 Query: 348 FKPPEPPKP 356 + PE + Sbjct: 105 YSGPERAQS 113 >6EF6-A nrPDB Length = 354 Score = 30.6 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 9/28 (32%), Positives = 17/28 (60%), Gaps = 3/28 (10%) Query: 145 GIIHRDLKPSNVAVNEDC---ELRILDF 169 G+IH DL+ +N+ V+ + ++DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >5JNE-A nrPDB Length = 367 Score = 29.9 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 17/95 (17%), Positives = 36/95 (37%), Gaps = 10/95 (10%) Query: 76 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQAL--SDEHVQFLVYQ 133 K L+H +I + ++ + E+ L TT L + + + + + Q Sbjct: 158 KVLQHPKIIKQATLLYLKKTLREDEEMGLTTTSTIMSLQDPISYTRMKYPSKSINCKHLQ 217 Query: 134 LLRGLKYIHSA--------GIIHRDLKPSNVAVNE 160 L ++HS + D+ N+A++E Sbjct: 218 CFDALWFLHSQLQIPTWQCPVCQIDIALENLAISE 252 >2GAI-A nrPDB Length = 633 Score = 29.9 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 28/143 (19%), Positives = 53/143 (37%), Gaps = 27/143 (18%) Query: 231 QLKRIMEVVGTPSPEVLAKISSEHARTYIQ-----SLPPMPQKDLSSIF---RGANPLAI 282 + I E V P + K+ ++ AR + SL P+ ++ S R + Sbjct: 115 TPRVIREAVKNPREIDMKKVRAQLARRILDRIVGYSLSPVLWRNFKSNLSAGRVQSATLK 174 Query: 283 DLLGR---MLVLDSDQ--RVSAAEALAHAYFSQYHDPEDEPEAEPYD----ESVEAKERT 333 + R +L + R++ F D E + +D + +++ + Sbjct: 175 LVCDREREILRFVPKKYHRITVN-------FDGLTAEIDVKEKKFFDAETLKEIQSIDEL 227 Query: 334 LEEWKELTYQEVLSFKPPEPPKP 356 + E K++ V F PPEP K Sbjct: 228 VVEEKKV---SVKKFAPPEPFKT 247 >6DFL-A nrPDB Length = 259 Score = 29.5 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 20/103 (19%), Positives = 36/103 (34%), Gaps = 5/103 (4%) Query: 89 VFTPATSIEDFSEVYLVTTLMGA--DLNNIV---KCQALSDEHVQFLVYQLLRGLKYIHS 143 + S ++VT + DL + + + LV + R + +H Sbjct: 97 AYGERGSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHR 156 Query: 144 AGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATR 186 AG+ HRD + ++ D + DF L+ AT Sbjct: 157 AGVNHRDCYICHFLLHTDKPVSADDFRLSVIDLHRAQTRDATP 199 >6H8S-A nrPDB Length = 301 Score = 29.1 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 9/43 (20%), Positives = 17/43 (39%) Query: 295 QRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEW 337 +R + L H +F+ + D + A P V E ++ Sbjct: 181 RRGTEERTLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQE 223 >5UOT-0 nrPDB Length = 619 Score = 28.7 bits (63), Expect = 3.6, Method: Composition-based stats. Identities = 18/91 (19%), Positives = 35/91 (38%), Gaps = 8/91 (8%) Query: 52 VKKLSRPFQSLIHARRTYR--ELRLLKHLKH--ENVIGLL--DVFTPATSIEDFSEVYLV 105 +K ++ + L+ R E RL ++ +N +G+L + I + E Y Sbjct: 334 IKMFNQDIEKLVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEVEKY-E 392 Query: 106 TTLMGADLNNIVKCQALSDEHVQFLVYQLLR 136 G +L V + + V + QL+ Sbjct: 393 KQYRGKELLGFVNYKTF-EIIVHQYIQQLVE 422 >4H05-A nrPDB Length = 273 Score = 28.7 bits (63), Expect = 4.0, Method: Composition-based stats. Identities = 10/27 (37%), Positives = 16/27 (59%), Gaps = 2/27 (7%) Query: 146 IIHRDLKPSNVAVN-EDCELR-ILDFG 170 + H DL P NV ++ CE+ ++D G Sbjct: 186 VCHGDLCPDNVLLDPRTCEVTGLIDVG 212 >5YJJ-A nrPDB Length = 713 Score = 28.3 bits (62), Expect = 4.8, Method: Composition-based stats. Identities = 30/132 (22%), Positives = 47/132 (35%), Gaps = 17/132 (12%) Query: 215 ELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIF 274 E+L +A+F G + I +L + +I + +P +DL Sbjct: 212 EML--EAIFFGHEEIKRLVAFQQ-----------EIIDHIQPIKQEFVPVERDEDLVEKV 258 Query: 275 RGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEA--KER 332 + L +L D QR +AL + D ED PE E + V A + Sbjct: 259 KSLTED-KGLKDTVLTFDKQQRDENLDALKEEVVGHFLDEED-PENETLVKEVYAILNDL 316 Query: 333 TLEEWKELTYQE 344 EE + L E Sbjct: 317 IKEEVRRLIADE 328 >2WDA-A nrPDB Length = 765 Score = 28.3 bits (62), Expect = 4.8, Method: Composition-based stats. Identities = 15/75 (20%), Positives = 21/75 (28%), Gaps = 6/75 (8%) Query: 286 GRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEV 345 M D +AL + +P AEPY + E + Sbjct: 19 SHMATADP------YDALRRRWLGITLGTGYDPAAEPYASRLAETGERAREHRATMAPTP 72 Query: 346 LSFKPPEPPKPPGSL 360 S P P PP + Sbjct: 73 TSLWPGHPFDPPAGI 87 >2HXI-A nrPDB Length = 241 Score = 28.3 bits (62), Expect = 4.8, Method: Composition-based stats. Identities = 12/61 (19%), Positives = 22/61 (36%), Gaps = 6/61 (9%) Query: 19 EVPQRLQGLRPV------GSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYREL 72 E+P R L + G +G+V + + ++ V L + RE+ Sbjct: 153 EIPARYHRLVILISSLITAEGGFGAVGAQEHEQGMEQFRVAVLGADPERFPALSHFAREI 212 Query: 73 R 73 R Sbjct: 213 R 213 >3OM6-A nrPDB Length = 456 Score = 28.3 bits (62), Expect = 5.4, Method: Composition-based stats. Identities = 11/49 (22%), Positives = 24/49 (48%), Gaps = 2/49 (4%) Query: 308 FSQYHDPEDEPEAEPYDESVEAKERTLEEWKEL--TYQEVLSFKPPEPP 354 F+ DP+D + Y +A +++++ WK +++ F P +P Sbjct: 88 FALAGDPKDSNDTSVYLFYKKAGDKSIDSWKNAGRVFKDSDKFVPNDPH 136 >1IU8-A nrPDB Length = 206 Score = 28.0 bits (61), Expect = 6.6, Method: Composition-based stats. Identities = 13/48 (27%), Positives = 20/48 (41%), Gaps = 1/48 (2%) Query: 215 ELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSL 262 LL G F G D + I+E + PEV+ +I + + L Sbjct: 3 ILLTGFEPFGGDDKNPTMD-IVEALSERIPEVVGEILPVSFKRAREKL 49 >5ITI-A nrPDB Length = 243 Score = 28.0 bits (61), Expect = 7.0, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 26/63 (41%), Gaps = 6/63 (9%) Query: 297 VSAAEALAHAY---FSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQ---EVLSFKP 350 ++ +A H + SQ ED + + +E +R L LT + +V+S Sbjct: 152 LTIEQARQHPWRHVLSQCLGREDLSQIDIQPIDLEPGDRLLLCSDGLTEELTDDVISIYL 211 Query: 351 PEP 353 EP Sbjct: 212 SEP 214 >2QG7-A nrPDB Length = 458 Score = 27.6 bits (60), Expect = 8.0, Method: Composition-based stats. Identities = 23/157 (14%), Positives = 48/157 (30%), Gaps = 41/157 (26%) Query: 46 LRQKVAVKKLSRPFQ--------SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIE 97 + VK +S+ + RE ++ L ++N+ + VF IE Sbjct: 121 TNILIKVKDMSKQAKYLIRLYGPKTDEIINREREKKISCILYNKNIAKKIYVFFTNGRIE 180 Query: 98 DFSEVYLV--TTLMGADLNNIVKC-----QALSDEHVQFLVYQLLRGL------------ 138 +F + Y + + ++ + + Q+ + + Sbjct: 181 EFMDGYALSREDIKNPKFQKLIAKNLKLLHDIKLNENLYKELQVTQKVPGTRPSFLWNTI 240 Query: 139 -KYIH-----SAGIIHRDLKPSNVAVNEDCELRILDF 169 KY H I D K N+ +++DF Sbjct: 241 WKYFHLLNEERKKICSFDAKA-NIL-------KLIDF 269 >4LXF-A nrPDB Length = 620 Score = 27.6 bits (60), Expect = 8.7, Method: Composition-based stats. Identities = 11/50 (22%), Positives = 18/50 (36%), Gaps = 1/50 (2%) Query: 305 HAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKEL-TYQEVLSFKPPEP 353 H +F + D P + Y S ++ T + T + SF P Sbjct: 165 HPWFQESRRDPDGPYGDYYVWSDTSERYTDARIIFVDTEESNWSFDPVRR 214 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.149 0.462 Lambda K H 0.267 0.0456 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,526,476 Number of Sequences: 36641 Number of extensions: 735760 Number of successful extensions: 6194 Number of sequences better than 10.0: 520 Number of HSP's better than 10.0 without gapping: 939 Number of HSP's successfully gapped in prelim test: 61 Number of HSP's that attempted gapping in prelim test: 2261 Number of HSP's gapped (non-prelim): 1252 length of query: 364 length of database: 10,336,785 effective HSP length: 98 effective length of query: 266 effective length of database: 6,745,967 effective search space: 1794427222 effective search space used: 1794427222 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 60 (27.6 bits)