BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q15435 (360 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6HKW-A nrPDB 714 0.0 6HLU-A nrPDB 114 4e-26 1M9S-A nrPDB 69 4e-12 4R6F-A nrPDB 67 1e-11 5YXM-A nrPDB 66 2e-11 6O00-A nrPDB 56 3e-08 5LFN-A nrPDB 54 1e-07 5ZSN-B nrPDB 52 6e-07 2FT3-A nrPDB 50 2e-06 5MX0-A nrPDB 49 3e-06 1DCE-A nrPDB 48 6e-06 6ICZ-o nrPDB 48 8e-06 1JL5-A nrPDB 47 1e-05 6GFF-I nrPDB 46 3e-05 2XOT-A nrPDB 44 7e-05 4R08-A nrPDB 42 3e-04 3J0A-A nrPDB 40 0.001 3JB9-j nrPDB 40 0.002 2Z80-A nrPDB 39 0.004 1XCD-A nrPDB 39 0.005 5GY2-A nrPDB 38 0.005 5YQ5-A nrPDB 38 0.007 2Z7X-A nrPDB 38 0.008 3A7C-A nrPDB 37 0.014 3CIG-A nrPDB 36 0.033 5Y3K-A nrPDB 34 0.087 5XJX-C nrPDB 34 0.099 3T6Q-A nrPDB 34 0.12 3B2D-A nrPDB 32 0.56 2QMW-A nrPDB 30 1.4 2EF0-A nrPDB 30 2.3 3A79-B nrPDB 30 2.4 3ULU-A nrPDB 29 2.6 1PUI-A nrPDB 28 5.5 4AY9-X nrPDB 28 5.7 3V7F-A nrPDB 28 8.8 1XWD-C nrPDB 27 9.7 >6HKW-A nrPDB Length = 363 Score = 714 bits (1842), Expect = 0.0, Method: Compositional matrix adjust. Identities = 360/360 (100%), Positives = 360/360 (100%) Query: 1 MAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGEEDPE 60 MAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGEEDPE Sbjct: 4 MAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGEEDPE 63 Query: 61 EEHELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQ 120 EEHELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQ Sbjct: 64 EEHELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQ 123 Query: 121 SLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE 180 SLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE Sbjct: 124 SLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE 183 Query: 181 NLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSN 240 NLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSN Sbjct: 184 NLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSN 243 Query: 241 RLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQE 300 RLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQE Sbjct: 244 RLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQE 303 Query: 301 FWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDATFVRF 360 FWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDATFVRF Sbjct: 304 FWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDATFVRF 363 >6HLU-A nrPDB Length = 974 Score = 114 bits (286), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 88/249 (35%), Positives = 135/249 (54%), Gaps = 3/249 (1%) Query: 83 LNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALT 142 L+ +I I L + L L N I I LE L+SL EL L NQI I L +L Sbjct: 120 LDRNQITDIAPLASLNSLSMLWLFGNKISDIAPLESLKSLTELQLSSNQITDIAPLASLK 179 Query: 143 ELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIE 202 L L +S N + +I ++ L L +L L +N+I+ I L++L L L L SN+I I Sbjct: 180 SLTELSLSGNNISDIAPLESLKSLTELSLSSNQITDIAPLASLKSLTELSLSSNQISDIA 239 Query: 203 NIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHN 262 +++L +L L L +N+I+ + L++L +LT L + SN++T I L +L +L EL LS N Sbjct: 240 PLESLKSLTELQLSRNQISDIAPLESLKSLTELQLSSNQITDIAPLASLKSLTELQLSRN 299 Query: 263 GIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARS 322 I I LE+ N L+ L + N+I I ++ L L E ++ N + +D+ L +S Sbjct: 300 QISDIAPLESLNSLSKLWLNGNQITDIAPLASLNSLTELELSSNQI---TDIAPLASLKS 356 Query: 323 LETVYLERN 331 L T++L N Sbjct: 357 LSTLWLSSN 365 Score = 112 bits (280), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 88/271 (32%), Positives = 136/271 (50%), Gaps = 19/271 (7%) Query: 87 RIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEI 146 +I I E LK + L L N I I L L+SL EL L N I I LE+L L Sbjct: 146 KISDIAPLESLKSLTELQLSSNQITDIAPLASLKSLTELSLSGNNISDIAPLESLKSLTE 205 Query: 147 LDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDT 206 L +S N + +I + L L +L L +N+IS I L +L L L+L N+I I +++ Sbjct: 206 LSLSSNQITDIAPLASLKSLTELSLSSNQISDIAPLESLKSLTELQLSRNQISDIAPLES 265 Query: 207 LTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEV 266 L +L L L N+IT + L +L +LT L + N+++ I L++L +L +L+L+ N I Sbjct: 266 LKSLTELQLSSNQITDIAPLASLKSLTELQLSRNQISDIAPLESLNSLSKLWLNGNQITD 325 Query: 267 IEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLE----------------- 309 I L + N LT L+++SN+I I ++ L L W++ N + Sbjct: 326 IAPLASLNSLTELELSSNQITDIAPLASLKSLSTLWLSSNQISDIAPLASLESLSELSLS 385 Query: 310 --SWSDLDELKGARSLETVYLERNPLQKDPQ 338 SD+ L SL + RNP+++ P+ Sbjct: 386 SNQISDISPLASLNSLTGFDVRRNPIKRLPE 416 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 83/245 (33%), Positives = 123/245 (50%), Gaps = 3/245 (1%) Query: 87 RIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEI 146 +I I L + L L +N I I L L SL L L+ N+I I LE+L L Sbjct: 102 QITDISPLASLNSLSMLWLDRNQITDIAPLASLNSLSMLWLFGNKISDIAPLESLKSLTE 161 Query: 147 LDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDT 206 L +S N + +I + L L +L L N IS I L +L L L L SN+I I + + Sbjct: 162 LQLSSNQITDIAPLASLKSLTELSLSGNNISDIAPLESLKSLTELSLSSNQITDIAPLAS 221 Query: 207 LTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEV 266 L +L L L N+I+ + L++L +LT L + N+++ I L++L +L EL LS N I Sbjct: 222 LKSLTELSLSSNQISDIAPLESLKSLTELQLSRNQISDIAPLESLKSLTELQLSSNQITD 281 Query: 267 IEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETV 326 I L + LT L ++ N+I I + L L + W+N N + +D+ L SL + Sbjct: 282 IAPLASLKSLTELQLSRNQISDIAPLESLNSLSKLWLNGNQI---TDIAPLASLNSLTEL 338 Query: 327 YLERN 331 L N Sbjct: 339 ELSSN 343 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 80/224 (35%), Positives = 121/224 (54%), Gaps = 3/224 (1%) Query: 108 NLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLK 167 N I I L L SL L L NQI I L +L L +L + N + +I ++ L L Sbjct: 101 NQITDISPLASLNSLSMLWLDRNQITDIAPLASLNSLSMLWLFGNKISDIAPLESLKSLT 160 Query: 168 KLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLD 227 +L L +N+I+ I L++L L L L N I I +++L +L L L N+IT + L Sbjct: 161 ELQLSSNQITDIAPLASLKSLTELSLSGNNISDIAPLESLKSLTELSLSSNQITDIAPLA 220 Query: 228 ALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIK 287 +L +LT LS+ SN+++ I L++L +L EL LS N I I LE+ LT L ++SN+I Sbjct: 221 SLKSLTELSLSSNQISDIAPLESLKSLTELQLSRNQISDIAPLESLKSLTELQLSSNQIT 280 Query: 288 KIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERN 331 I ++ L L E ++ N + SD+ L+ SL ++L N Sbjct: 281 DIAPLASLKSLTELQLSRNQI---SDIAPLESLNSLSKLWLNGN 321 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 79/223 (35%), Positives = 116/223 (52%) Query: 80 DVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLE 139 ++ L+ +I I LK + L L N I I LE L+SL EL L NQI I LE Sbjct: 205 ELSLSSNQITDIAPLASLKSLTELSLSSNQISDIAPLESLKSLTELQLSRNQISDIAPLE 264 Query: 140 ALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIR 199 +L L L +S N + +I + L L +L L N+IS I L +L+ L L L N+I Sbjct: 265 SLKSLTELQLSSNQITDIAPLASLKSLTELQLSRNQISDIAPLESLNSLSKLWLNGNQIT 324 Query: 200 AIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYL 259 I + +L +L L L N+IT + L +L +L+ L + SN+++ I L +L +L EL L Sbjct: 325 DIAPLASLNSLTELELSSNQITDIAPLASLKSLSTLWLSSNQISDIAPLASLESLSELSL 384 Query: 260 SHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFW 302 S N I I L + N LT D+ N IK++ +++ W Sbjct: 385 SSNQISDISPLASLNSLTGFDVRRNPIKRLPETITGFDMEILW 427 >1M9S-A nrPDB Length = 605 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 51/152 (33%), Positives = 79/152 (51%), Gaps = 22/152 (14%) Query: 154 LRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIR-------------- 199 +++++G+ L + KLFL NK++ I+ L+NL L L L N+I+ Sbjct: 55 IKSVQGIQYLPNVTKLFLNGNKLTDIKPLTNLKNLGWLFLDENKIKDLSSLKDLKKLKSL 114 Query: 200 -----AIENIDTLTNL---ESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNL 251 I +I+ L +L ESL+LG NKIT + L LT L LS++ N+++ I L L Sbjct: 115 SLEHNGISDINGLVHLPQLESLYLGNNKITDITVLSRLTKLDTLSLEDNQISDIVPLAGL 174 Query: 252 VNLRELYLSHNGIEVIEGLENNNKLTMLDIAS 283 L+ LYLS N I + L L +L++ S Sbjct: 175 TKLQNLYLSKNHISDLRALAGLKNLDVLELFS 206 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/156 (37%), Positives = 90/156 (57%) Query: 84 NHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTE 143 N+ I ++G + L V L L N + I+ L L++L L L +N+IK + +L+ L + Sbjct: 51 NNSDIKSVQGIQYLPNVTKLFLNGNKLTDIKPLTNLKNLGWLFLDENKIKDLSSLKDLKK 110 Query: 144 LEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIEN 203 L+ L + N + +I G+ L +L+ L+L NNKI+ I LS L +L L L N+I I Sbjct: 111 LKSLSLEHNGISDINGLVHLPQLESLYLGNNKITDITVLSRLTKLDTLSLEDNQISDIVP 170 Query: 204 IDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQS 239 + LT L++L+L KN I+ L+ L L NL VL + S Sbjct: 171 LAGLTKLQNLYLSKNHISDLRALAGLKNLDVLELFS 206 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 47/159 (29%), Positives = 76/159 (47%), Gaps = 22/159 (13%) Query: 118 ELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKI- 176 EL S+ ++ ++ IK ++ ++ L + L ++ N L +I+ + L L LFL NKI Sbjct: 41 ELNSIDQIIANNSDIKSVQGIQYLPNVTKLFLNGNKLTDIKPLTNLKNLGWLFLDENKIK 100 Query: 177 ---------------------SKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFL 215 S I L +L QL+ L LG+N+I I + LT L++L L Sbjct: 101 DLSSLKDLKKLKSLSLEHNGISDINGLVHLPQLESLYLGNNKITDITVLSRLTKLDTLSL 160 Query: 216 GKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNL 254 N+I+ + L LT L L + N ++ + L L NL Sbjct: 161 EDNQISDIVPLAGLTKLQNLYLSKNHISDLRALAGLKNL 199 Score = 32.0 bits (71), Expect = 0.41, Method: Compositional matrix adjust. Identities = 32/131 (24%), Positives = 52/131 (39%), Gaps = 47/131 (35%) Query: 245 IEGLQNLVNLRELYLS-------------------------------------------- 260 ++G+Q L N+ +L+L+ Sbjct: 58 VQGIQYLPNVTKLFLNGNKLTDIKPLTNLKNLGWLFLDENKIKDLSSLKDLKKLKSLSLE 117 Query: 261 HNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGA 320 HNGI I GL + +L L + +N+I I +S LT+L + DN + SD+ L G Sbjct: 118 HNGISDINGLVHLPQLESLYLGNNKITDITVLSRLTKLDTLSLEDNQI---SDIVPLAGL 174 Query: 321 RSLETVYLERN 331 L+ +YL +N Sbjct: 175 TKLQNLYLSKN 185 >4R6F-A nrPDB Length = 331 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 84/282 (29%), Positives = 136/282 (48%), Gaps = 47/282 (16%) Query: 84 NHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIEN--LEAL 141 N+ I ++G + L V+ L L N + I L+EL +L L+L +NQ++ + E L Sbjct: 49 NNSDIKSVQGIQYLPNVRYLALGGNKLHDISALKELTNLGWLNLSNNQLETLPQGVFEKL 108 Query: 142 TELEILDISFNLLRNI-EGV-DKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIR 199 T L L++S N L ++ +GV ++L L L L NN I+ I + QMLE Sbjct: 109 TNLTTLNLSNNQLTSLPQGVFERLASLTTLNLSNNNIANIND-------QMLE------- 154 Query: 200 AIENIDTL----TNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKI--EGLQNLVN 253 + N+ TL NL L+ N + L LTNLT L++ SN +I E ++L + Sbjct: 155 GLTNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTS 214 Query: 254 LRELYLSHNGI-----EVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLL 308 L L LS+N I +++EGL N LT L+++ N + ++ W + N Sbjct: 215 LTTLNLSNNNIANINDQMLEGLTN---LTTLNLSHNNLARL------------WKHAN-- 257 Query: 309 ESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSV 350 + LKG +L T+ L N + P+ K + +L ++ Sbjct: 258 -PGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTL 298 >5YXM-A nrPDB Length = 203 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 52/130 (40%), Positives = 79/130 (60%), Gaps = 9/130 (6%) Query: 77 DAEDVDLNHYRIGKIEGFEV----LKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQI 132 +AE V+L H I IE + LK K L L N I+ I +L +++LR L L N I Sbjct: 29 EAEKVEL-HGMIPPIEKMDATLSTLKACKHLALSTNNIEKISSLSGMENLRILSLGRNLI 87 Query: 133 KKIENLEALTE-LEILDISFNLLRNIEGVDKLTRLKKLFLVNNKIS---KIENLSNLHQL 188 KKIENL+A+ + LE L IS+N + ++ G++KL L+ L++ NNKI+ +I+ L+ L +L Sbjct: 88 KKIENLDAVADTLEELWISYNQIASLSGIEKLVNLRVLYMSNNKITNWGEIDKLAALDKL 147 Query: 189 QMLELGSNRI 198 + L L N + Sbjct: 148 EDLLLAGNPL 157 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 50/173 (28%), Positives = 83/173 (47%), Gaps = 34/173 (19%) Query: 198 IRAIENID----TLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVN 253 I IE +D TL + L L N I K+ +L + NL +LS+ N + KIE L + + Sbjct: 39 IPPIEKMDATLSTLKACKHLALSTNNIEKISSLSGMENLRILSLGRNLIKKIENLDAVAD 98 Query: 254 -LRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWS 312 L EL++S+N I + G+E L L+ +M++N + +W Sbjct: 99 TLEELWISYNQIASLSGIE----------------------KLVNLRVLYMSNNKITNWG 136 Query: 313 DLDELKGARSLETVYLERNPLQKD-------PQYRRKVMLALPSVRQIDATFV 358 ++D+L LE + L NPL D +YR +V+ LP+++++D V Sbjct: 137 EIDKLAALDKLEDLLLAGNPLYNDYKENNATSEYRIEVVKRLPNLKKLDGMPV 189 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 41/104 (39%), Positives = 61/104 (58%), Gaps = 4/104 (3%) Query: 163 LTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTN-LESLFLGKNKIT 221 L K L L N I KI +LS + L++L LG N I+ IEN+D + + LE L++ N+I Sbjct: 52 LKACKHLALSTNNIEKISSLSGMENLRILSLGRNLIKKIENLDAVADTLEELWISYNQIA 111 Query: 222 KLQNLDALTNLTVLSMQSNRLT---KIEGLQNLVNLRELYLSHN 262 L ++ L NL VL M +N++T +I+ L L L +L L+ N Sbjct: 112 SLSGIEKLVNLRVLYMSNNKITNWGEIDKLAALDKLEDLLLAGN 155 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 34/100 (34%), Positives = 55/100 (55%), Gaps = 1/100 (1%) Query: 71 TINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQ-SLRELDLYD 129 T++ + + + L+ I KI ++ ++ L L +NLIK IENL+ + +L EL + Sbjct: 48 TLSTLKACKHLALSTNNIEKISSLSGMENLRILSLGRNLIKKIENLDAVADTLEELWISY 107 Query: 130 NQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKL 169 NQI + +E L L +L +S N + N +DKL L KL Sbjct: 108 NQIASLSGIEKLVNLRVLYMSNNKITNWGEIDKLAALDKL 147 >6O00-A nrPDB Length = 820 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 76/240 (31%), Positives = 119/240 (49%), Gaps = 28/240 (11%) Query: 91 IEGFEVLKKVKTLCLRQNLIKCIENLEELQ-SLRELDLYD--------NQIKKIENLEAL 141 I+G LK++K L L+ NL K + + ++ L++L + + N +KK+ N L Sbjct: 537 IDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVN---L 593 Query: 142 TELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE---NLSNLHQLQMLELGSNRI 198 TELE+ I +L R + L L+++ L +N + IE + +LH+L L+L N I Sbjct: 594 TELEL--IRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHI 651 Query: 199 RAIE-NIDTLTNLESLFLGKNKITKLQN-LDALTNLTVLSMQSNRLTKIEG----LQNLV 252 I I LTNLE L+L +NKI K+ L L L + N LT + LQNL Sbjct: 652 AYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQ 711 Query: 253 NLRELYLSHNGIEVIEG-LENNNKLTMLDIASNRIKKIEN-ISHLTELQEFWMNDNLLES 310 NL ++ N IE + L KL L + +N ++ + + + LT L + + N LE Sbjct: 712 NLA---VTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLEC 768 >5LFN-A nrPDB Length = 337 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 76/274 (27%), Positives = 125/274 (45%), Gaps = 39/274 (14%) Query: 82 DLNHYRIGKIEGFEVLKKV----KTLCLRQNLIKCIE--NLEELQSLRELDLYDNQIKKI 135 DL H K+ G + + KV K L L++N + + + +L L L QI+++ Sbjct: 10 DLQHVICDKV-GLQKIPKVSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREV 68 Query: 136 EN--LEALTELEILDISFNLLRNIEG--VDKLTRLKKLFLVNNKISKIEN--LSNLHQLQ 189 L +L L +S N +R + D LT L L+L +NK++++ LS L L Sbjct: 69 AAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLF 128 Query: 190 MLELGSNRIRAIE--NIDTLTNLESLFLGKNKITKLQN--LDALTNLTVLSMQSNRLTKI 245 +L+L +N+IR + +L L+L +N ++ LQ LD + NL + N+L+ Sbjct: 129 ILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSY 188 Query: 246 E--GLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWM 303 L L + EL LSHN ++ I D A + L+ W+ Sbjct: 189 PSAALSKLRVVEELKLSHNPLKSIP-----------DNAFQSFGRY--------LETLWL 229 Query: 304 NDNLLESWSDLDELKGARSLETVYLERNPLQKDP 337 ++ LE +SD G +L+ V+LE N L + P Sbjct: 230 DNTNLEKFSD-GAFLGVTTLKHVHLENNRLNQLP 262 >5ZSN-B nrPDB Length = 823 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 97/208 (46%), Gaps = 29/208 (13%) Query: 141 LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE--NLSNLHQLQMLELGSNRI 198 LT+L++L + N + + V T L +L+L NN I++I+ + +NL+QLQ+L+L N Sbjct: 181 LTKLKVLSLKDNNVTTVPTVLPST-LTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCP 239 Query: 199 RAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEG--LQNLVNLRE 256 R T ++ + DALT L VL + SN L + +N+ NL+E Sbjct: 240 RCYNAPFPCTPCKN---NSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQE 296 Query: 257 LYLSHNGI-------EVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLE 309 L LS N + + + L N L LD++ N ELQ + + NL + Sbjct: 297 LDLSQNFLAKEIGDAKFLHFLPN---LIQLDLSFN-----------FELQVYRASMNLSQ 342 Query: 310 SWSDLDELKGARSLETVYLERNPLQKDP 337 ++S L LK R V+ E Q P Sbjct: 343 AFSSLKSLKILRIRGYVFKELKSFQLSP 370 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 75/268 (27%), Positives = 112/268 (41%), Gaps = 54/268 (20%) Query: 80 DVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSL---RELDLYDNQIKKIE 136 D+ N K F+ L +K L L NLI N E Q L R LD +N++ + Sbjct: 477 DLSKNSIFFIKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLH 536 Query: 137 N--LEALTELEILDISFN--------LLRNIEGVDKLTRLKKLFLVNNKISKIENLS-NL 185 + E L +LE+LDIS N + + L L+KL + +N IS + + Sbjct: 537 STAFEELRKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMES 596 Query: 186 HQLQMLELGSNRI---------RAIENIDTLTNLESLFLGKNKITKLQN--LDALT-NLT 233 L+ LE N + R ++ L LE L + KN ++ L + D + NL Sbjct: 597 ESLRTLEFRGNHLDVLWRDGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLK 656 Query: 234 VLSMQSNRLTKI--EGLQNLVNLRELYLSHNGIEVIEG-------------LENNN---- 274 LS+ N L E L+ L NL L LSHN + + L+NN Sbjct: 657 NLSLAKNGLKSFIWEKLRYLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSL 716 Query: 275 ---------KLTMLDIASNRIKKIENIS 293 +L LD++SN+I+ I+ S Sbjct: 717 TKYFLQDAFQLRYLDLSSNKIQMIQKTS 744 Score = 36.6 bits (83), Expect = 0.017, Method: Compositional matrix adjust. Identities = 49/144 (34%), Positives = 73/144 (50%), Gaps = 19/144 (13%) Query: 155 RNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAI--ENIDTLTNLES 212 R+ G LT LK L+L N++ +I LQ+L L +N I +I E + L N+E Sbjct: 99 RSFSG---LTYLKSLYLDGNQLLEIPQ-GLPPSLQLLSLEANNIFSIRKEQLTELANIEI 154 Query: 213 LFLGKNKITKLQNL-------DALTNLT---VLSMQSNRLTKIEGLQNLVNLRELYLSHN 262 L+LG+N + DA NLT VLS++ N +T + + L ELYL +N Sbjct: 155 LYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTTVPTVLP-STLTELYLYNN 213 Query: 263 GIEVIE--GLENNNKLTMLDIASN 284 I I+ N N+L +LD++ N Sbjct: 214 MIAEIQEDDFNNLNQLQILDLSGN 237 >2FT3-A nrPDB Length = 332 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 64/206 (31%), Positives = 94/206 (45%), Gaps = 37/206 (17%) Query: 163 LTRLKKLFLVNNKISKI--ENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKI 220 L L L LVNNKISKI + S L +LQ L + N + I + ++L L + N+I Sbjct: 77 LQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPP-NLPSSLVELRIHDNRI 135 Query: 221 TKLQN--LDALTNLTVLSMQSNRL----------------------TKIEGLQNLV--NL 254 K+ L N+ + M N L K+ G+ + L Sbjct: 136 RKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETL 195 Query: 255 RELYLSHNGIEVI--EGLENNNKLTMLDIASNRIKKIEN--ISHLTELQEFWMNDNLLES 310 EL+L HN I+ I E L +KL L + N+I+ IEN +S L L+E +++N L Sbjct: 196 NELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLSR 255 Query: 311 -WSDLDELKGARSLETVYLERNPLQK 335 + L +LK L+ VYL N + K Sbjct: 256 VPAGLPDLK---LLQVVYLHTNNITK 278 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 59/193 (30%), Positives = 94/193 (48%), Gaps = 36/193 (18%) Query: 87 RIGKI--EGFEVLKKVKTLCLRQN-LIKCIENLEELQSLRELDLYDNQIKKIEN--LEAL 141 +I KI + F L+K++ L + +N L++ NL SL EL ++DN+I+K+ L Sbjct: 89 KISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLP--SSLVELRIHDNRIRKVPKGVFSGL 146 Query: 142 TELEILDISFNLLRN-------IEGVD---------KLTRLKK--------LFLVNNKIS 177 + +++ N L N +G+ KLT + K L L +NKI Sbjct: 147 RNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQ 206 Query: 178 KIE--NLSNLHQLQMLELGSNRIRAIEN--IDTLTNLESLFLGKNKITKLQ-NLDALTNL 232 IE +L +L L LG N+IR IEN + L L L L NK++++ L L L Sbjct: 207 AIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLSRVPAGLPDLKLL 266 Query: 233 TVLSMQSNRLTKI 245 V+ + +N +TK+ Sbjct: 267 QVVYLHTNNITKV 279 >5MX0-A nrPDB Length = 362 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 49/179 (27%), Positives = 88/179 (49%), Gaps = 12/179 (6%) Query: 164 TRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRIRA----IENIDTLTNLESLFLGK 217 +R+K ++ NN+I+ I+ N L + L N+I + + L +LE L+L Sbjct: 91 SRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLYLDH 150 Query: 218 NKITKLQNLDALTNLTVLSMQSNRLTKIE--GLQNLVNLRELYLSHNGI-EVIEGLENNN 274 N +T++ +L L + N+++++ L+ L NL LYL HN I EV + Sbjct: 151 NNLTRMPG-PLPRSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQEVGSSMRGLR 209 Query: 275 KLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPL 333 L +LD++ N ++K+ + + L++ +M N + + D +GA L V L N L Sbjct: 210 SLILLDLSYNHLRKVPD-GLPSALEQLYMEHNNVYTVPD-SYFRGAPKLLYVRLSHNSL 266 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 52/203 (25%), Positives = 94/203 (46%), Gaps = 36/203 (17%) Query: 76 RDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQIK 133 R E + L+H + ++ G + + ++ L L N I + N LE L++L L L N+I+ Sbjct: 141 RHLERLYLDHNNLTRMPG-PLPRSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQ 199 Query: 134 KI-ENLEALTELEILDISFNLLRNIE--------------------------GVDKL--T 164 ++ ++ L L +LD+S+N LR + G KL Sbjct: 200 EVGSSMRGLRSLILLDLSYNHLRKVPDGLPSALEQLYMEHNNVYTVPDSYFRGAPKLLYV 259 Query: 165 RLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQ 224 RL L NN ++ N N L L+L N+++ I ++T NLE+L+L N+I + Sbjct: 260 RLSHNSLTNNGLAS--NTFNSSSLLELDLSYNQLQKIPPVNT--NLENLYLQGNRINEFS 315 Query: 225 NLDALTNLTVLSMQSNRLTKIEG 247 T + V++ ++ +++G Sbjct: 316 ISSFCTVVDVVNFSKLQVLRLDG 338 >1DCE-A nrPDB Length = 567 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 37/109 (33%), Positives = 60/109 (55%), Gaps = 4/109 (3%) Query: 100 VKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIEN-LEALTELEILDISFNLLRNIE 158 V+ L L + + +LE+L + LDL N+++ + L AL LE+L S N L N++ Sbjct: 443 VRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNALENVD 502 Query: 159 GVDKLTRLKKLFLVNNKI---SKIENLSNLHQLQMLELGSNRIRAIENI 204 GV L RL++L L NN++ + I+ L + +L +L L N + E I Sbjct: 503 GVANLPRLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGNSLCQEEGI 551 Score = 35.8 bits (81), Expect = 0.027, Method: Compositional matrix adjust. Identities = 35/133 (26%), Positives = 62/133 (46%), Gaps = 20/133 (15%) Query: 118 ELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIE-GVDKLTRLKKLFLVNNKI 176 E +R L L + + +LE L + LD+S N LR + + L L+ L +N + Sbjct: 439 EYADVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNAL 498 Query: 177 SKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLS 236 ++ ++NL +LQ L L +NR++ + +Q L + L +L+ Sbjct: 499 ENVDGVANLPRLQELLLCNNRLQ-------------------QSAAIQPLVSCPRLVLLN 539 Query: 237 MQSNRLTKIEGLQ 249 +Q N L + EG+Q Sbjct: 540 LQGNSLCQEEGIQ 552 Score = 29.6 bits (65), Expect = 2.2, Method: Compositional matrix adjust. Identities = 28/125 (22%), Positives = 56/125 (44%), Gaps = 23/125 (18%) Query: 252 VNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKK----------------------- 288 ++R L+L+H + V+ LE +T LD++ NR++ Sbjct: 441 ADVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNALEN 500 Query: 289 IENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALP 348 ++ +++L LQE + +N L+ + + L L + L+ N L ++ + ++ LP Sbjct: 501 VDGVANLPRLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGNSLCQEEGIQERLAEMLP 560 Query: 349 SVRQI 353 SV I Sbjct: 561 SVSSI 565 >6ICZ-o nrPDB Length = 255 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 38/94 (40%), Positives = 55/94 (58%), Gaps = 3/94 (3%) Query: 123 RELDLYDNQIKKIENLEA-LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI-E 180 RELDL +I IENL A L + + +D S N +R ++G L RLK L + NN+I +I E Sbjct: 22 RELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGE 81 Query: 181 NLSN-LHQLQMLELGSNRIRAIENIDTLTNLESL 213 L L L L L +N + + ++D L +L+SL Sbjct: 82 GLDQALPCLTELILTNNSLVELGDLDPLASLKSL 115 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 32/98 (32%), Positives = 48/98 (48%), Gaps = 2/98 (2%) Query: 259 LSHNGIEVIEGLENNNKLTMLDIASNRIKKI-ENISH-LTELQEFWMNDNLLESWSDLDE 316 S N I ++G +L L + +NRI +I E + L L E + +N L DLD Sbjct: 49 FSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELGDLDP 108 Query: 317 LKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQID 354 L +SL + + RNP+ YR V+ +P VR +D Sbjct: 109 LASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQVRVLD 146 Score = 36.6 bits (83), Expect = 0.019, Method: Compositional matrix adjust. Identities = 36/113 (31%), Positives = 63/113 (55%), Gaps = 5/113 (4%) Query: 63 HELPVDMETINLDRDAED-VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCI-ENLEE-L 119 +++PV +E + D D +D + I K++GF +L+++KTL + N I I E L++ L Sbjct: 29 YKIPV-IENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQAL 87 Query: 120 QSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLV 172 L EL L +N + ++ +L+ L L+ L ++LRN K RL ++ V Sbjct: 88 PCLTELILTNNSLVELGDLDPLASLKSLTY-LSILRNPVTNKKHYRLYVIYKV 139 >1JL5-A nrPDB Length = 454 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 75/319 (23%), Positives = 145/319 (45%), Gaps = 57/319 (17%) Query: 74 LDRDAEDVDLNHYRIGKI------------------EGFEVLKKVKTLCLRQNLIKCIEN 115 LDR A +++LN+ + + E E+ + +K+L + N +K + + Sbjct: 69 LDRQAHELELNNLGLSSLPELPPHLESLVASCNSLTELPELPQSLKSLLVDNNNLKALSD 128 Query: 116 LEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNK 175 L L L L + +NQ++K+ L+ + L+I+D+ N L+ + D L+ + NN+ Sbjct: 129 LPPL--LEYLGVSNNQLEKLPELQNSSFLKIIDVDNNSLKKLP--DLPPSLEFIAAGNNQ 184 Query: 176 ISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVL 235 + ++ L NL L + +N ++ + D +LES+ G N + +L L L LT + Sbjct: 185 LEELPELQNLPFLTAIYADNNSLKKLP--DLPLSLESIVAGNNILEELPELQNLPFLTTI 242 Query: 236 SMQSNRLTKIEGLQN-----------LVNLRELYLSHNGIEVIEGL-----ENNNKLTML 279 +N L + L L +L EL S ++V E + E L L Sbjct: 243 YADNNLLKTLPDLPPSLEALNVRDNYLTDLPELPQSLTFLDVSENIFSGLSELPPNLYYL 302 Query: 280 DIASNRIKKIENISHLTELQEFWMNDN--------------LLESWSDLDELKG-ARSLE 324 + +SN I+ + ++ L+E +++N L+ S++ L E+ ++L+ Sbjct: 303 NASSNEIRSLCDLP--PSLEELNVSNNKLIELPALPPRLERLIASFNHLAEVPELPQNLK 360 Query: 325 TVYLERNPLQKDPQYRRKV 343 +++E NPL++ P V Sbjct: 361 QLHVEYNPLREFPDIPESV 379 >6GFF-I nrPDB Length = 618 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 59/206 (28%), Positives = 95/206 (46%), Gaps = 20/206 (9%) Query: 121 SLRELDLYDNQIKKIEN--LEALTELEILDISFNLLR-----NIEGVDKLTRLKKLFLVN 173 +LR LDL N+I ++ +ALT LE L ++ N L + G+ L R+ L L Sbjct: 55 ALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSG 114 Query: 174 NKISK--IENL----SNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQN-- 225 N + +E L +LH L + E R+ + LE L L N + +++ Sbjct: 115 NSLYSGLLERLLGEAPSLHTLSLAENSLTRLTR-HTFRDMPALEQLDLHSNVLMDIEDGA 173 Query: 226 LDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNN---KLTMLDIA 282 + L LT L++ N LT I +L LR L LS N IE + +LT LD+ Sbjct: 174 FEGLPRLTHLNLSRNSLTCISDF-SLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLR 232 Query: 283 SNRIKKIENISHLTELQEFWMNDNLL 308 N++ +++ L L +++NL+ Sbjct: 233 ENKLLHFPDLAALPRLIYLNLSNNLI 258 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 69/253 (27%), Positives = 107/253 (42%), Gaps = 45/253 (17%) Query: 79 EDVDLNHYRIGKIE--GFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIE 136 E +DL+ + IE FE L ++ L L +N + CI + LQ LR LDL N I+ + Sbjct: 157 EQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFS-LQQLRVLDLSCNSIEAFQ 215 Query: 137 -------------------------NLEALTELEILDISFNLLRNIEGVDKLTRLKKLFL 171 +L AL L L++S NL+R G + + K + Sbjct: 216 TASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDS--KGIHA 273 Query: 172 VNNKISKIE------NLSN--LHQLQMLELGSNRIRAIEN--IDTLTNLESLFLGKNKIT 221 + S + N S L QL L+L N I I + ++ LT+L L L +N + Sbjct: 274 PSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLR 333 Query: 222 KLQ--NLDALTNLTVLSMQSNRLTKIE-GLQNLVNLRELYLSHNGIEVIEG--LENNNKL 276 + L +L L +L + N L +E G + L +LR L L N + + N L Sbjct: 334 TFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASL 393 Query: 277 TMLDIASNRIKKI 289 L++ NR+ Sbjct: 394 QRLNLQGNRVSPC 406 Score = 32.7 bits (73), Expect = 0.26, Method: Compositional matrix adjust. Identities = 29/106 (27%), Positives = 51/106 (48%), Gaps = 9/106 (8%) Query: 89 GKIEGFEVLKKVKTLCLRQNLIKCIE-NLEELQSLRELDLYDNQIKKIENLEALTELEIL 147 G + G E ++ L L+ N + ++ +L L+ L+L +N++ + LE+L Sbjct: 465 GALGGLEA--SLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVL 522 Query: 148 DI---SFNLLRNIEGVDKLTRLKKLFLVNNKISKIEN---LSNLHQ 187 D+ SF+LL T L++L+L N +S N + LHQ Sbjct: 523 DLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQ 568 >2XOT-A nrPDB Length = 361 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 60/213 (28%), Positives = 103/213 (48%), Gaps = 55/213 (25%) Query: 136 ENLEALTELEILDISFNLLRNIEG---VDKLTRLKKLFLVNNKISKI--ENLSNLHQLQM 190 ++L + T L LD+S N L + +LT L L L +N ++ I E + L+ Sbjct: 35 QSLPSYTAL--LDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHLNFISSEAFVPVPNLRY 92 Query: 191 LELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIE--GL 248 L+L SN + ++ E LF + LQ L+ VL + +N + ++ Sbjct: 93 LDLSSNHLHTLD--------EFLF------SDLQALE------VLLLYNNHIVVVDRNAF 132 Query: 249 QNLVNLRELYLSHNGIE--VIEGLENNNKLT---MLDIASNRIKKIENISHLTELQEFWM 303 +++ L++LYLS N I +E +++ NKL +LD++SN++KK+ LT+LQ+ Sbjct: 133 EDMAQLQKLYLSQNQISRFPVELIKDGNKLPKLMLLDLSSNKLKKLP----LTDLQK--- 185 Query: 304 NDNLLESWSDLDELKGARSLETVYLERNPLQKD 336 L +W +K +YL NPL+ D Sbjct: 186 ----LPAW-----VKNG-----LYLHNNPLECD 204 >4R08-A nrPDB Length = 811 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 66/231 (28%), Positives = 105/231 (45%), Gaps = 37/231 (16%) Query: 78 AEDVDLNHYRIGKIEGFEVLKKVKTLCLRQN----LIKCIENLEELQSLRELDLYDNQIK 133 A D+ LN FE L + L L N ++ E + ++ LDL +N++ Sbjct: 463 ALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTE-FSAIPHVKYLDLTNNRLD 521 Query: 134 KIENLEALTEL---EILDISFN--------LLRNIEGVDKLTRLKKLFLVNNKISKIENL 182 +N ALTEL E+LD+S+N + ++E + T LK L L +N I + + Sbjct: 522 -FDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDK 580 Query: 183 SNLHQLQMLEL--GSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSN 240 NL ++EL NR+ + N D S+F G L NLT L + N Sbjct: 581 YNLESKSLVELVFSGNRLDILWNDDD-NRYISIFKG------------LKNLTRLDLSLN 627 Query: 241 RLTKI--EGLQNL-VNLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRI 286 RL I E NL +L EL+++ N ++ L+ +L +LD+ N++ Sbjct: 628 RLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKL 678 Score = 34.3 bits (77), Expect = 0.082, Method: Compositional matrix adjust. Identities = 62/220 (28%), Positives = 97/220 (44%), Gaps = 47/220 (21%) Query: 119 LQSLRELDLYDNQIKKIEN--LEALTELEILDISFNLLRNI--EGVDKLTRLKKLFLV-- 172 L++LREL L DNQ+ +I + E+LTEL ++ N + NI EG+ +L LK L+L Sbjct: 102 LKNLRELLLEDNQLPQIPSGLPESLTELSLIQ---NNIYNITKEGISRLINLKNLYLAWN 158 Query: 173 --NNKISK--------IENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITK 222 NK+ + E L+NL L + + + ++L LFL +I Sbjct: 159 CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPP----KLPSSLRKLFLSNTQIKY 214 Query: 223 L--QNLDALTNLTVLSMQSN---------RLTKIEG----------LQNLVNLRELYLSH 261 + ++ L NLT+L + N +G QNL LR L LS Sbjct: 215 ISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSS 274 Query: 262 NGIEVIEG--LENNNKLTMLDIASNR-IKKIENISHLTEL 298 + I +N L +LD+ N + +I + + LT L Sbjct: 275 TSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTML 314 Score = 33.5 bits (75), Expect = 0.16, Method: Compositional matrix adjust. Identities = 50/205 (24%), Positives = 86/205 (41%), Gaps = 58/205 (28%) Query: 166 LKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQN 225 L +F + ++ ENL ++ L + + ++ + + +++ L L N++ N Sbjct: 468 LNSIFFIGP--NQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRL-DFDN 524 Query: 226 LDALTNLT---VLSMQSN----RLTKI----EGLQNLVNLRELYLSHNG----------- 263 ALT L+ VL + N R+ + E +QN NL+ L LSHN Sbjct: 525 ASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLE 584 Query: 264 -------------------------IEVIEGLENNNKLTMLDIASNRIKKIENISHL--- 295 I + +GL+N LT LD++ NR+K I N + L Sbjct: 585 SKSLVELVFSGNRLDILWNDDDNRYISIFKGLKN---LTRLDLSLNRLKHIPNEAFLNLP 641 Query: 296 TELQEFWMNDNLLE--SWSDLDELK 318 L E +NDN+L+ +W+ L + Sbjct: 642 ASLTELHINDNMLKFFNWTLLQQFP 666 >3J0A-A nrPDB Length = 844 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 65/229 (28%), Positives = 103/229 (44%), Gaps = 35/229 (15%) Query: 80 DVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLE----------ELQSLRELDLYD 129 D+ NH I + + F+ L+K++TL LR N + I + +L +L +++L Sbjct: 344 DLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTA 403 Query: 130 NQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI---ENLSNLH 186 N I EN LE LDI + LLR + L+ L L N+ S + S Sbjct: 404 NLIHLSEN-----RLENLDILYFLLR-------VPHLQILILNQNRFSSCSGDQTPSENP 451 Query: 187 QLQMLELGSNRIR-------AIENIDTLTNLESLFLGKNKITKLQN--LDALTNLTVLSM 237 L+ L LG N ++ + + L++L+ L+L N + L LT L LS+ Sbjct: 452 SLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSL 511 Query: 238 QSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRI 286 SNRLT + NL L +S N + + + L++LDI N+ Sbjct: 512 NSNRLTVLSHNDLPANLEILDISRNQL-LAPNPDVFVSLSVLDITHNKF 559 >3JB9-j nrPDB Length = 239 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 38/137 (27%), Positives = 60/137 (43%), Gaps = 30/137 (21%) Query: 124 ELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLS 183 ELDL QI IENL L ++ + +D +N I + N Sbjct: 22 ELDLRWYQIPIIENLGVLRDVH------------DAID---------FTDNDIRYLGNFP 60 Query: 184 NLHQLQMLELGSNRIRAIEN--IDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNR 241 + +LQ L G+NRI AI L NL++L L +N + ++ +LD L + + Sbjct: 61 RMKRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIADLDPLASCP-------Q 113 Query: 242 LTKIEGLQNLVNLRELY 258 LT + + N V ++ Y Sbjct: 114 LTNLSCIDNPVAQKQYY 130 Score = 35.0 bits (79), Expect = 0.050, Method: Compositional matrix adjust. Identities = 33/125 (26%), Positives = 56/125 (44%), Gaps = 6/125 (4%) Query: 241 RLTKIEGLQNLVNLRELY----LSHNGIEVIEGLENNNKLTMLDIASNRIKKI-ENISH- 294 R +I ++NL LR+++ + N I + +L L +NRI I +I Sbjct: 26 RWYQIPIIENLGVLRDVHDAIDFTDNDIRYLGNFPRMKRLQTLLCGNNRITAIAPDIGKV 85 Query: 295 LTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQID 354 L L+ + N L+ +DLD L L + NP+ + YR ++ +PS+ +D Sbjct: 86 LPNLKTLSLAQNHLQEIADLDPLASCPQLTNLSCIDNPVAQKQYYRLYLIWRIPSLHILD 145 Query: 355 ATFVR 359 VR Sbjct: 146 FERVR 150 >2Z80-A nrPDB Length = 353 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 40/121 (33%), Positives = 60/121 (49%), Gaps = 17/121 (14%) Query: 100 VKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQIKKIE--NLEALTELEILDISFNLLR 155 VK+L L N I I N L+ +L+ L L N I IE + +L LE LD+S+N L Sbjct: 54 VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLS 113 Query: 156 NIEG--VDKLTRLKKLFLVNNK---ISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNL 210 N+ L+ L L L+ N + + S+L +LQ+L +G N+DT T + Sbjct: 114 NLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVG--------NMDTFTKI 165 Query: 211 E 211 + Sbjct: 166 Q 166 Score = 30.8 bits (68), Expect = 0.95, Method: Compositional matrix adjust. Identities = 21/61 (34%), Positives = 32/61 (52%), Gaps = 4/61 (6%) Query: 235 LSMQSNRLTKIEG--LQNLVNLRELYLSHNGIEVIE--GLENNNKLTMLDIASNRIKKIE 290 L + +NR+T I LQ VNL+ L L+ NGI IE + L LD++ N + + Sbjct: 57 LDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLS 116 Query: 291 N 291 + Sbjct: 117 S 117 >1XCD-A nrPDB Length = 329 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 57/221 (25%), Positives = 101/221 (45%), Gaps = 38/221 (17%) Query: 146 ILDISFNLLRNIEGVD--KLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRIRAI 201 +LD+ N + I+ D L L L L+NNKISKI + L +L+ L L N+++ + Sbjct: 56 LLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKEL 115 Query: 202 ENIDTLTNLESLFLGKNKITKLQN--LDALTNLTVLSMQSNRL-------TKIEGLQNLV 252 T L+ L + +N+ITK++ + L + V+ + +N L +G++ L Sbjct: 116 PEKMPKT-LQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLS 174 Query: 253 NLR------------------ELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKKIEN- 291 +R EL+L N I ++ L+ N L L ++ N I ++N Sbjct: 175 YIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNG 234 Query: 292 -ISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERN 331 +++ L+E +N+N L L + ++ VYL N Sbjct: 235 SLANTPHLRELHLNNNKLVKVP--GGLADHKYIQVVYLHNN 273 >5GY2-A nrPDB Length = 455 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 41/128 (32%), Positives = 65/128 (50%), Gaps = 13/128 (10%) Query: 215 LGKNKITKL--QNLDALTNLTVLSMQSNRLTKIE--GLQNLVNLRELYLSHNGIEVIEG- 269 L K+KI L T+L L++ N + KI+ L +L +L LS N + I+ Sbjct: 282 LSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFWGLTHLLKLNLSQNFLGSIDSR 341 Query: 270 -LENNNKLTMLDIASNRIKKIENISH--LTELQEFWMNDNLLESWSD--LDELKGARSLE 324 EN +KL +LD++ N I+ + + S L L+E ++ N L+S D D L SL+ Sbjct: 342 MFENLDKLEVLDLSYNHIRALGDQSFLGLPNLKELALDTNQLKSVPDGIFDRLT---SLQ 398 Query: 325 TVYLERNP 332 ++L NP Sbjct: 399 KIWLHTNP 406 Score = 28.9 bits (63), Expect = 3.2, Method: Compositional matrix adjust. Identities = 33/111 (29%), Positives = 56/111 (50%), Gaps = 8/111 (7%) Query: 94 FEVLKKVKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQIKKIEN--LEALTELEILDI 149 F ++ L L QN I I++ L L +L+L N + I++ E L +LE+LD+ Sbjct: 295 FSHFTDLEQLTLAQNEINKIDDNAFWGLTHLLKLNLSQNFLGSIDSRMFENLDKLEVLDL 354 Query: 150 SFNLLRNI--EGVDKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSN 196 S+N +R + + L LK+L L N++ + + L LQ + L +N Sbjct: 355 SYNHIRALGDQSFLGLPNLKELALDTNQLKSVPDGIFDRLTSLQKIWLHTN 405 >5YQ5-A nrPDB Length = 430 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 64/229 (27%), Positives = 107/229 (46%), Gaps = 40/229 (17%) Query: 164 TRLKKLFLVNNKI--SKIEN--LSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNK 219 T LK++ L +NKI KI+ + L L L L N + +LE L LG N+ Sbjct: 113 THLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHLEHNNLEEFP-FPLPKSLERLLLGYNE 171 Query: 220 ITKLQN--LDALTNLTVLSMQSNRLT----KIEGLQNLVNLRELYLSHNGIEVIE----- 268 I+KLQ +D L NLT+L + N L K + + L +L L N +E + Sbjct: 172 ISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDKIFAKMEKLMQLNLCSNRLESMPPGLPS 231 Query: 269 -----GLENNNKLTMLDIASNRIKKIENI--SHLTELQEFWMN----DNLLESWSDLDEL 317 LENN+ ++ + +++ K+ + SH +LQ+ N N++E ++L Sbjct: 232 SLMYLSLENNSISSIPEKYFDKLPKLHTLRMSH-NKLQDIPYNIFNLPNIVELSVGHNKL 290 Query: 318 KGA----RSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDA---TFVR 359 K A R+LE +YL+ N ++K + + PS+ + T++R Sbjct: 291 KQAFYIPRNLEHLYLQNNEIEK-----MNLTVMCPSIDPLHYHHLTYIR 334 >2Z7X-A nrPDB Length = 549 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 40/121 (33%), Positives = 60/121 (49%), Gaps = 17/121 (14%) Query: 100 VKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQIKKIE--NLEALTELEILDISFNLLR 155 VK+L L N I I N L+ +L+ L L N I IE + +L LE LD+S+N L Sbjct: 28 VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLS 87 Query: 156 NIEG--VDKLTRLKKLFLVNNK---ISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNL 210 N+ L+ L L L+ N + + S+L +LQ+L +G N+DT T + Sbjct: 88 NLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVG--------NMDTFTKI 139 Query: 211 E 211 + Sbjct: 140 Q 140 Score = 33.1 bits (74), Expect = 0.19, Method: Compositional matrix adjust. Identities = 64/305 (20%), Positives = 120/305 (39%), Gaps = 80/305 (26%) Query: 80 DVDLNHYRIGKIEGFEVLKKVKTLCLR------QNLIKCIENLEELQSLRELDLYDNQIK 133 D DL+ + ++ E +K R ++L + ++ L ++ L EL+ D + Sbjct: 205 DTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLN 264 Query: 134 KIENLEALTELEILDIS--------------FNLLRNIEGVDKLT-RLKKLFLVNNKISK 178 + N A ++D F L ++ + LT R+K++ + N+K+ Sbjct: 265 GVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFL 324 Query: 179 IENLSNLH--QLQMLELGSNRI-------RAIENIDTLTNLESLFLGKNKITKLQ----- 224 + L + H L+ L+L N + A E D +L++L L +N + L+ Sbjct: 325 VPCLLSQHLKSLEYLDLSENLMVEEYLKNSACE--DAWPSLQTLILRQNHLASLEKTGET 382 Query: 225 --NLDALTNLTV--------------------LSMQSNRLTKIEGL-------------- 248 L LTN+ + L++ S R+ + G Sbjct: 383 LLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNN 442 Query: 249 -----QNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIEN--ISHLTELQEF 301 NL L+ELY+S N + + L +L I+ N++K + + LT LQ+ Sbjct: 443 LNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNQLKSVPDGIFDRLTSLQKI 502 Query: 302 WMNDN 306 W++ N Sbjct: 503 WLHTN 507 Score = 30.8 bits (68), Expect = 0.98, Method: Compositional matrix adjust. Identities = 21/61 (34%), Positives = 32/61 (52%), Gaps = 4/61 (6%) Query: 235 LSMQSNRLTKIEG--LQNLVNLRELYLSHNGIEVIE--GLENNNKLTMLDIASNRIKKIE 290 L + +NR+T I LQ VNL+ L L+ NGI IE + L LD++ N + + Sbjct: 31 LDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLS 90 Query: 291 N 291 + Sbjct: 91 S 91 >3A7C-A nrPDB Length = 580 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 57/228 (25%), Positives = 100/228 (43%), Gaps = 41/228 (17%) Query: 94 FEVLKKVKTLCLRQN---LIKCIENLEELQSLRELDLYDN-----QIKKIENLEALTELE 145 + +L+KVK + + + L+ C + + L+SL LDL +N +K A L+ Sbjct: 332 YSLLEKVKRITVENSKVFLVPCSFS-QHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQ 390 Query: 146 ILDISFNLLRNIEGVDK----LTRLKKLFLVNNKISKIENLSNLH-QLQMLELGSNRIRA 200 L +S N LR+++ + L L L + N + + +++ L L S IR Sbjct: 391 TLVLSQNHLRSMQKTGEILLTLKNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRV 450 Query: 201 IENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLS 260 ++ T LE L + N NLD+ + L L+ELY+S Sbjct: 451 VKTCIPQT-LEVLDVSNN------NLDSFSLF------------------LPRLQELYIS 485 Query: 261 HNGIEVIEGLENNNKLTMLDIASNRIKKIEN--ISHLTELQEFWMNDN 306 N ++ + L ++ IASN++K + + LT LQ+ W++ N Sbjct: 486 RNKLKTLPDASLFPVLLVMKIASNQLKSVPDGIFDRLTSLQKIWLHTN 533 >3CIG-A nrPDB Length = 697 Score = 35.8 bits (81), Expect = 0.033, Method: Compositional matrix adjust. Identities = 34/103 (33%), Positives = 55/103 (53%), Gaps = 8/103 (7%) Query: 171 LVNNKISKIE--NLSNLHQLQMLELGSNRIRAIEN--IDTLTNLESLFLGKNKITKL--Q 224 L +N++ ++ N + QL +L+ G N I +E L L+ L L N+++++ Q Sbjct: 32 LTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQ 91 Query: 225 NLDALTNLTVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGIE 265 TNLT L + SN + KI+ +N NL +L LSHNG+ Sbjct: 92 TFVFCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLS 134 >5Y3K-A nrPDB Length = 802 Score = 34.3 bits (77), Expect = 0.087, Method: Compositional matrix adjust. Identities = 31/89 (34%), Positives = 49/89 (55%), Gaps = 6/89 (6%) Query: 98 KKVKTLCLRQNLIKCI--ENLEELQSLRELDLYDNQIKKIEN--LEALTELEILDISFN- 152 K ++ L LR N + +L L +L LDL NQ+K + N L + T+L+ LD+S N Sbjct: 632 KSLQLLRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLDVSRNS 691 Query: 153 LLRNIEGVDKL-TRLKKLFLVNNKISKIE 180 ++ + G L TRL++L L N + +E Sbjct: 692 IIFVVPGFFALATRLRELNLSANALRTVE 720 Score = 33.5 bits (75), Expect = 0.15, Method: Compositional matrix adjust. Identities = 38/123 (30%), Positives = 53/123 (43%), Gaps = 26/123 (21%) Query: 166 LKKLFLVNNKISKI--ENLSNLHQLQMLELGSNRIRA------------------IENID 205 L+ L L N I + E+L+NL L++L++G N R + Sbjct: 201 LEYLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCVECPHKFPQLHSDTFS 260 Query: 206 TLTNLESLFLGKNKITKLQN--LDALTNLTVLSMQSNRL----TKIEGLQNLVNLRELYL 259 L+ LE L L + + +L L NLTVL + N L TK + Q L LR L L Sbjct: 261 HLSRLEGLVLKDSSLYQLNPRWFRGLGNLTVLDLSENFLYDCITKTKAFQGLAQLRRLNL 320 Query: 260 SHN 262 S N Sbjct: 321 SFN 323 >5XJX-C nrPDB Length = 433 Score = 33.9 bits (76), Expect = 0.099, Method: Compositional matrix adjust. Identities = 73/262 (27%), Positives = 112/262 (42%), Gaps = 52/262 (19%) Query: 81 VDLNHYRI-GKIEGFEVLKKVKTLCLRQNLI--KCIENLEELQSLRELDLYDNQIKKI-- 135 +DL+ R+ G I GF VL + L L QNL+ L SL ++DL N++ Sbjct: 185 LDLSGNRLTGSIPGF-VLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIP 243 Query: 136 ENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGS 195 E++ L +L +LD+S+N RL F +L L+ LQ L L Sbjct: 244 ESINRLNQLVLLDLSYN------------RLSGPF--------PSSLQGLNSLQALMLKG 283 Query: 196 N---RIRAIEN-IDTLTNLESLFLGKNKI--TKLQNLDALTNLTVLSMQSNRLT---KIE 246 N EN L NL L L I + ++L L +L VL ++ N LT +E Sbjct: 284 NTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLE 343 Query: 247 GLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDN 306 +++ +L EL L+ N + E + M R ++ N + L ++ Sbjct: 344 -FRDVKHLSELRLNDNSLTGPVPFERDTVWRM-----RRKLRLYNNAGLCVNRD------ 391 Query: 307 LLESWSDLDELKGARSLETVYL 328 SDLD+ G++S TV L Sbjct: 392 -----SDLDDAFGSKSGSTVRL 408 >3T6Q-A nrPDB Length = 606 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 59/202 (29%), Positives = 94/202 (46%), Gaps = 32/202 (15%) Query: 112 CIENLEELQSLRELDLYDNQIKKIE----NLEALTELEILDISFN--LLRNIEGVDKLTR 165 C+ENLE +LRELDL + I+ + L L+ L+ L++S+N L E + + Sbjct: 345 CLENLE---NLRELDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQ 401 Query: 166 LKKLFLVNNKISKIEN----LSNLHQLQMLELGSN--RIRAIENIDTLTNLESL-----F 214 L+ L L ++ K+++ NLH L++L L + I + + D L L+ L Sbjct: 402 LELLDLAFTRL-KVKDAQSPFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHLNLQGNH 460 Query: 215 LGKNKITKLQNLDALTNLTVLSMQSNRLTKIE--GLQNLVNLRELYLSHN-----GIEVI 267 K I K +L L L +L + L+ I+ +L + + LSHN IE + Sbjct: 461 FPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAFTSLKMMNHVDLSHNRLTSSSIEAL 520 Query: 268 EGLENNNKLTMLDIASNRIKKI 289 L K L++ASN I I Sbjct: 521 SHL----KGIYLNLASNHISII 538 Score = 32.3 bits (72), Expect = 0.29, Method: Compositional matrix adjust. Identities = 33/85 (38%), Positives = 47/85 (55%), Gaps = 6/85 (7%) Query: 188 LQMLELGSNRIRAIEN-IDTLTNLESLFLGKNKITKLQNLDA--LTNLTVLSMQSN--RL 242 LQ L+L + + + + + L+ L+ L L NK L + A +LT LS++ N RL Sbjct: 280 LQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTKRL 339 Query: 243 TKIEG-LQNLVNLRELYLSHNGIEV 266 G L+NL NLREL LSH+ IE Sbjct: 340 ELGTGCLENLENLRELDLSHDDIET 364 >3B2D-A nrPDB Length = 603 Score = 31.6 bits (70), Expect = 0.56, Method: Compositional matrix adjust. Identities = 49/174 (28%), Positives = 76/174 (43%), Gaps = 31/174 (17%) Query: 108 NLIKCIEN--LEELQSLRELDLYDNQIKKI--ENLEALTELEILDISFNLLRNIE--GVD 161 N + I N L +L LDL QI I + ++ +L L ++ N L + ++ Sbjct: 40 NFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLN 99 Query: 162 KLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKIT 221 LK LFL+ IS +E + + L NLESL+LG N I+ Sbjct: 100 GPKSLKHLFLIQTGISNLEFIP--------------------VHNLENLESLYLGSNHIS 139 Query: 222 KLQNLDALT--NLTVLSMQSNRLTKI--EGLQNLVNLRELYLSHNGIEVIEGLE 271 ++ NL VL Q+N + I E +++L L L+ NG V +G+E Sbjct: 140 SIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNV-KGIE 192 >2QMW-A nrPDB Length = 267 Score = 30.0 bits (66), Expect = 1.4, Method: Compositional matrix adjust. Identities = 15/42 (35%), Positives = 24/42 (57%), Gaps = 2/42 (4%) Query: 147 LDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQL 188 LDI+F L N G D ++ +KK++ + IS+ N + HQ Sbjct: 84 LDINFALYGN--GTDSISDIKKVYSIAPAISQTTNYIHQHQF 123 >2EF0-A nrPDB Length = 301 Score = 29.6 bits (65), Expect = 2.3, Method: Compositional matrix adjust. Identities = 22/84 (26%), Positives = 45/84 (53%), Gaps = 5/84 (5%) Query: 205 DTLTNLESLFLG-KNKITKLQNLDALT---NLTVLSMQSNRLTKIEGLQNLVNLRELYLS 260 D NLE G ++ + + ++AL + V++ S+R ++ L +L+ L+E++ Sbjct: 92 DVAKNLERFVEGIAARVFRHETVEALARHAKVPVVNALSDRAHPLQALADLLTLKEVFGG 151 Query: 261 HNGIEVIEGLENNNKL-TMLDIAS 283 G+EV + NN L ++L++A Sbjct: 152 LAGLEVAWVGDGNNVLNSLLEVAP 175 >3A79-B nrPDB Length = 562 Score = 29.6 bits (65), Expect = 2.4, Method: Compositional matrix adjust. Identities = 33/112 (29%), Positives = 53/112 (47%), Gaps = 8/112 (7%) Query: 98 KKVKTLCLRQNLIK--CIENLEELQSLRELDLYDNQIKKIENLEALT--ELEILDISFNL 153 + K L L QN I + ++ L LR L L N+I+ ++ L +LE LD+S N Sbjct: 52 PRTKALSLSQNSISELRMPDISFLSELRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHNR 111 Query: 154 LRNIEGVDKLTRLKKLFLVNNK---ISKIENLSNLHQLQMLELGSNRIRAIE 202 L+NI + L+ L L N + + NL +L L L + + R ++ Sbjct: 112 LQNISCC-PMASLRHLDLSFNDFDVLPVCKEFGNLTKLTFLGLSAAKFRQLD 162 Score = 28.9 bits (63), Expect = 4.1, Method: Compositional matrix adjust. Identities = 37/143 (25%), Positives = 67/143 (46%), Gaps = 16/143 (11%) Query: 177 SKIENLSNLHQLQMLELGSNRIRAIENIDTLT----NLESLFLGKNKITKL---QNLDAL 229 S + S L +LQ L L N ++ + +T +LE+L + N + + Sbjct: 368 SVFQGCSTLKRLQTLILQRNGLKNFFKVALMTKNMSSLETLDVSLNSLNSHAYDRTCAWA 427 Query: 230 TNLTVLSMQSNRLTK--IEGLQNLVNLRELYLSHNG--IEVIEGLENNNKLTMLDIASNR 285 ++ VL++ SN LT L V + +L HN + + + + + L L++ASN+ Sbjct: 428 ESILVLNLSSNMLTGSVFRCLPPKVKVLDL---HNNRIMSIPKDVTHLQALQELNVASNQ 484 Query: 286 IKKIEN--ISHLTELQEFWMNDN 306 +K + + LT LQ W++DN Sbjct: 485 LKSVPDGVFDRLTSLQYIWLHDN 507 >3ULU-A nrPDB Length = 694 Score = 29.3 bits (64), Expect = 2.6, Method: Compositional matrix adjust. Identities = 36/130 (27%), Positives = 56/130 (43%), Gaps = 26/130 (20%) Query: 142 TELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAI 201 T + +L+++ N LR + N + QL L++G N I + Sbjct: 35 TNITVLNLTHNQLRRLPAA--------------------NFTRYSQLTSLDVGFNTISKL 74 Query: 202 EN--IDTLTNLESLFLGKNKITKL--QNLDALTNLTVLSMQSNRLTKIEG--LQNLVNLR 255 E L L+ L L N++++L + TNLT L + SN + KI+ NL Sbjct: 75 EPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLI 134 Query: 256 ELYLSHNGIE 265 L LSHNG+ Sbjct: 135 TLDLSHNGLS 144 Score = 29.3 bits (64), Expect = 2.6, Method: Compositional matrix adjust. Identities = 51/185 (27%), Positives = 83/185 (44%), Gaps = 24/185 (12%) Query: 93 GFEVLKKVKTLCLRQNLIKCIEN-LEELQSLRELDLYD-----NQIKKIENLEALTELEI 146 F ++ ++ L LR+ +K +++ Q LR L + D + LE L +LEI Sbjct: 459 SFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEI 518 Query: 147 LDISFNLLR----------NIEGVDKLTRLKKLFLVNNKISKI--ENLSNLHQLQMLELG 194 LD+ N L I + L+ L L L +N +I E +L +L++++LG Sbjct: 519 LDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLG 578 Query: 195 SNRIRAIEN--IDTLTNLESLFLGKNKITKLQNL---DALTNLTVLSMQSNRL-TKIEGL 248 N + + + +L+SL L KN IT ++ A NLT L M+ N E + Sbjct: 579 LNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESI 638 Query: 249 QNLVN 253 VN Sbjct: 639 AWFVN 643 >1PUI-A nrPDB Length = 210 Score = 28.1 bits (61), Expect = 5.5, Method: Compositional matrix adjust. Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 4/57 (7%) Query: 201 IENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLREL 257 I ++ + T +E F G++ K L+ LTN L+ R +K G L+NL E+ Sbjct: 18 IRHLPSDTGIEVAFAGRSNAGKSSALNTLTNQKSLA----RTSKTPGRTQLINLFEV 70 >4AY9-X nrPDB Length = 350 Score = 28.1 bits (61), Expect = 5.7, Method: Compositional matrix adjust. Identities = 35/124 (28%), Positives = 58/124 (46%), Gaps = 14/124 (11%) Query: 197 RIRAIEN--IDTLTNLESLFLGKNKITKLQNLDALTNLTVLSM----QSNRLTKI--EGL 248 ++R I+ +LE + + +N + ++ D +NL L ++N L I E Sbjct: 41 KLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAF 100 Query: 249 QNLVNLRELYLSHNGIEVIEGLENNNKL--TMLDIASN-RIKKIENISHLT---ELQEFW 302 QNL NL+ L +S+ GI+ + + + L +LDI N I IE S + E W Sbjct: 101 QNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILW 160 Query: 303 MNDN 306 +N N Sbjct: 161 LNKN 164 >3V7F-A nrPDB Length = 224 Score = 27.7 bits (60), Expect = 8.8, Method: Compositional matrix adjust. Identities = 13/29 (44%), Positives = 19/29 (65%) Query: 214 FLGKNKITKLQNLDALTNLTVLSMQSNRL 242 FL K+++ LQ +LTNLTVL ++ L Sbjct: 176 FLTKDEVASLQEYISLTNLTVLFLEPREL 204 >1XWD-C nrPDB Length = 252 Score = 27.3 bits (59), Expect = 9.7, Method: Compositional matrix adjust. Identities = 35/124 (28%), Positives = 58/124 (46%), Gaps = 14/124 (11%) Query: 197 RIRAIEN--IDTLTNLESLFLGKNKITKLQNLDALTNLTVLSM----QSNRLTKI--EGL 248 ++R I+ +LE + + +N + ++ D +NL L ++N L I E Sbjct: 41 KLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAF 100 Query: 249 QNLVNLRELYLSHNGIEVIEGLENNNKL--TMLDIASN-RIKKIENISHLT---ELQEFW 302 QNL NL+ L +S+ GI+ + + + L +LDI N I IE S + E W Sbjct: 101 QNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILW 160 Query: 303 MNDN 306 +N N Sbjct: 161 LNKN 164 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6HKW-A nrPDB 429 e-120 6HLU-A nrPDB 228 2e-60 6O00-A nrPDB 171 3e-43 4R6F-A nrPDB 166 1e-41 3J0A-A nrPDB 162 2e-40 5LFN-A nrPDB 159 1e-39 6GFF-I nrPDB 152 3e-37 1JL5-A nrPDB 151 5e-37 4R08-A nrPDB 150 1e-36 1M9S-A nrPDB 138 4e-33 5MX0-A nrPDB 137 6e-33 5ZSN-B nrPDB 132 3e-31 2FT3-A nrPDB 124 5e-29 5YXM-A nrPDB 113 1e-25 6ICZ-o nrPDB 99 2e-21 2XOT-A nrPDB 98 5e-21 1DCE-A nrPDB 97 1e-20 3JB9-j nrPDB 86 2e-17 Sequences not found previously or not previously below threshold: 5Y3M-A nrPDB 121 5e-28 5Y3K-A nrPDB 116 2e-26 1XCD-A nrPDB 106 2e-23 5YQ5-A nrPDB 98 6e-21 4QDH-A nrPDB 98 6e-21 3G06-A nrPDB 98 7e-21 5KH1-A nrPDB 90 1e-18 3WPI-A nrPDB 90 1e-18 3CIG-A nrPDB 88 5e-18 5XJX-C nrPDB 88 6e-18 3ULU-A nrPDB 88 7e-18 5GY2-A nrPDB 81 7e-16 4PUF-A nrPDB 79 4e-15 3A7C-A nrPDB 78 5e-15 2Z80-A nrPDB 78 9e-15 3V44-A nrPDB 75 5e-14 2V9T-B nrPDB 70 1e-12 3B2D-A nrPDB 69 4e-12 5D3I-A nrPDB 68 5e-12 3A79-B nrPDB 68 7e-12 1OGQ-A nrPDB 67 1e-11 3T6Q-A nrPDB 67 1e-11 2Z7X-A nrPDB 66 2e-11 3CVR-A nrPDB 66 3e-11 3RG1-A nrPDB 66 3e-11 4ECN-A nrPDB 64 1e-10 2Z7X-B nrPDB 62 3e-10 4AY9-X nrPDB 60 2e-09 5Y31-B nrPDB 58 7e-09 1XWD-C nrPDB 54 1e-07 5LJ5-W nrPDB 53 2e-07 4WYK-A nrPDB 48 7e-06 2IFG-A nrPDB 47 9e-06 1KOH-A nrPDB 45 6e-05 6J5T-G nrPDB 42 3e-04 4NUY-A nrPDB 42 5e-04 2CA6-A nrPDB 41 8e-04 6MDV-A nrPDB 41 0.001 4PEQ-B nrPDB 39 0.002 2Q4G-W nrPDB 39 0.003 2BNH-A nrPDB 39 0.004 4PBW-B nrPDB 37 0.016 3TSR-E nrPDB 36 0.021 4PBV-A nrPDB 35 0.066 3G04-C nrPDB 32 0.34 1X9N-A nrPDB 30 2.2 4NOI-A nrPDB 30 2.2 3R2W-A nrPDB 30 2.2 5EE0-A nrPDB 29 3.7 2AXV-A nrPDB 28 6.6 2L3O-A nrPDB 27 8.6 >6HKW-A nrPDB Length = 363 Score = 429 bits (1102), Expect = e-120, Method: Composition-based stats. Identities = 360/360 (100%), Positives = 360/360 (100%) Query: 1 MAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGEEDPE 60 MAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGEEDPE Sbjct: 4 MAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGEEDPE 63 Query: 61 EEHELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQ 120 EEHELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQ Sbjct: 64 EEHELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQ 123 Query: 121 SLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE 180 SLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE Sbjct: 124 SLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE 183 Query: 181 NLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSN 240 NLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSN Sbjct: 184 NLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSN 243 Query: 241 RLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQE 300 RLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQE Sbjct: 244 RLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQE 303 Query: 301 FWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDATFVRF 360 FWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDATFVRF Sbjct: 304 FWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDATFVRF 363 >6HLU-A nrPDB Length = 974 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 89/269 (33%), Positives = 140/269 (52%), Gaps = 3/269 (1%) Query: 68 DMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDL 127 D+ + + L+ +I I L + L L N I I LE L+SL EL L Sbjct: 105 DISPLASLNSLSMLWLDRNQITDIAPLASLNSLSMLWLFGNKISDIAPLESLKSLTELQL 164 Query: 128 YDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQ 187 NQI I L +L L L +S N + +I ++ L L +L L +N+I+ I L++L Sbjct: 165 SSNQITDIAPLASLKSLTELSLSGNNISDIAPLESLKSLTELSLSSNQITDIAPLASLKS 224 Query: 188 LQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEG 247 L L L SN+I I +++L +L L L +N+I+ + L++L +LT L + SN++T I Sbjct: 225 LTELSLSSNQISDIAPLESLKSLTELQLSRNQISDIAPLESLKSLTELQLSSNQITDIAP 284 Query: 248 LQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNL 307 L +L +L EL LS N I I LE+ N L+ L + N+I I ++ L L E ++ N Sbjct: 285 LASLKSLTELQLSRNQISDIAPLESLNSLSKLWLNGNQITDIAPLASLNSLTELELSSNQ 344 Query: 308 LESWSDLDELKGARSLETVYLERNPLQKD 336 + +D+ L +SL T++L N + Sbjct: 345 I---TDIAPLASLKSLSTLWLSSNQISDI 370 Score = 210 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 90/271 (33%), Positives = 142/271 (52%), Gaps = 3/271 (1%) Query: 68 DMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDL 127 D+ + + ++ L+ +I I LK + L L N I I LE L+SL EL L Sbjct: 149 DIAPLESLKSLTELQLSSNQITDIAPLASLKSLTELSLSGNNISDIAPLESLKSLTELSL 208 Query: 128 YDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQ 187 NQI I L +L L L +S N + +I ++ L L +L L N+IS I L +L Sbjct: 209 SSNQITDIAPLASLKSLTELSLSSNQISDIAPLESLKSLTELQLSRNQISDIAPLESLKS 268 Query: 188 LQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEG 247 L L+L SN+I I + +L +L L L +N+I+ + L++L +L+ L + N++T I Sbjct: 269 LTELQLSSNQITDIAPLASLKSLTELQLSRNQISDIAPLESLNSLSKLWLNGNQITDIAP 328 Query: 248 LQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNL 307 L +L +L EL LS N I I L + L+ L ++SN+I I ++ L L E ++ N Sbjct: 329 LASLNSLTELELSSNQITDIAPLASLKSLSTLWLSSNQISDIAPLASLESLSELSLSSNQ 388 Query: 308 LESWSDLDELKGARSLETVYLERNPLQKDPQ 338 + SD+ L SL + RNP+++ P+ Sbjct: 389 I---SDISPLASLNSLTGFDVRRNPIKRLPE 416 Score = 203 bits (516), Expect = 9e-53, Method: Composition-based stats. Identities = 84/265 (31%), Positives = 129/265 (48%), Gaps = 5/265 (1%) Query: 86 YRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELE 145 +I I L + L L +N I I L L SL L L+ N+I I LE+L L Sbjct: 101 NQITDISPLASLNSLSMLWLDRNQITDIAPLASLNSLSMLWLFGNKISDIAPLESLKSLT 160 Query: 146 ILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENID 205 L +S N + +I + L L +L L N IS I L +L L L L SN+I I + Sbjct: 161 ELQLSSNQITDIAPLASLKSLTELSLSGNNISDIAPLESLKSLTELSLSSNQITDIAPLA 220 Query: 206 TLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIE 265 +L +L L L N+I+ + L++L +LT L + N+++ I L++L +L EL LS N I Sbjct: 221 SLKSLTELSLSSNQISDIAPLESLKSLTELQLSRNQISDIAPLESLKSLTELQLSSNQIT 280 Query: 266 VIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLET 325 I L + LT L ++ N+I I + L L + W+N N + +D+ L SL Sbjct: 281 DIAPLASLKSLTELQLSRNQISDIAPLESLNSLSKLWLNGNQI---TDIAPLASLNSLTE 337 Query: 326 VYLERNPLQKDPQYRRKVMLALPSV 350 + L N + + +L ++ Sbjct: 338 LELSSNQITDIA--PLASLKSLSTL 360 Score = 174 bits (440), Expect = 6e-44, Method: Composition-based stats. Identities = 80/235 (34%), Positives = 120/235 (51%) Query: 68 DMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDL 127 D+ + + ++ L+ +I I LK + L L N I I LE L+SL EL L Sbjct: 193 DIAPLESLKSLTELSLSSNQITDIAPLASLKSLTELSLSSNQISDIAPLESLKSLTELQL 252 Query: 128 YDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQ 187 NQI I LE+L L L +S N + +I + L L +L L N+IS I L +L+ Sbjct: 253 SRNQISDIAPLESLKSLTELQLSSNQITDIAPLASLKSLTELQLSRNQISDIAPLESLNS 312 Query: 188 LQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEG 247 L L L N+I I + +L +L L L N+IT + L +L +L+ L + SN+++ I Sbjct: 313 LSKLWLNGNQITDIAPLASLNSLTELELSSNQITDIAPLASLKSLSTLWLSSNQISDIAP 372 Query: 248 LQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFW 302 L +L +L EL LS N I I L + N LT D+ N IK++ +++ W Sbjct: 373 LASLESLSELSLSSNQISDISPLASLNSLTGFDVRRNPIKRLPETITGFDMEILW 427 Score = 157 bits (396), Expect = 7e-39, Method: Composition-based stats. Identities = 69/218 (31%), Positives = 115/218 (52%) Query: 68 DMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDL 127 D+ + + ++ L+ +I I E LK + L L +N I I LE L+SL EL L Sbjct: 215 DIAPLASLKSLTELSLSSNQISDIAPLESLKSLTELQLSRNQISDIAPLESLKSLTELQL 274 Query: 128 YDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQ 187 NQI I L +L L L +S N + +I ++ L L KL+L N+I+ I L++L+ Sbjct: 275 SSNQITDIAPLASLKSLTELQLSRNQISDIAPLESLNSLSKLWLNGNQITDIAPLASLNS 334 Query: 188 LQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEG 247 L LEL SN+I I + +L +L +L+L N+I+ + L +L +L+ LS+ SN+++ I Sbjct: 335 LTELELSSNQITDIAPLASLKSLSTLWLSSNQISDIAPLASLESLSELSLSSNQISDISP 394 Query: 248 LQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNR 285 L +L +L + N I+ + + +L + Sbjct: 395 LASLNSLTGFDVRRNPIKRLPETITGFDMEILWNDFSS 432 Score = 147 bits (371), Expect = 6e-36, Method: Composition-based stats. Identities = 70/219 (31%), Positives = 115/219 (52%), Gaps = 5/219 (2%) Query: 133 KKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLE 192 + I+ LE+L L L +S N + +I + L L L+L N+I+ I L++L+ L ML Sbjct: 82 RIIQPLESLKSLSELSLSSNQITDISPLASLNSLSMLWLDRNQITDIAPLASLNSLSMLW 141 Query: 193 LGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLV 252 L N+I I +++L +L L L N+IT + L +L +LT LS+ N ++ I L++L Sbjct: 142 LFGNKISDIAPLESLKSLTELQLSSNQITDIAPLASLKSLTELSLSGNNISDIAPLESLK 201 Query: 253 NLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWS 312 +L EL LS N I I L + LT L ++SN+I I + L L E ++ N + S Sbjct: 202 SLTELSLSSNQITDIAPLASLKSLTELSLSSNQISDIAPLESLKSLTELQLSRNQI---S 258 Query: 313 DLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVR 351 D+ L+ +SL + L N + + +L ++ Sbjct: 259 DIAPLESLKSLTELQLSSNQITDIA--PLASLKSLTELQ 295 Score = 96.0 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 46/162 (28%), Positives = 75/162 (46%) Query: 68 DMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDL 127 D+ + + ++ L+ +I I E L + L L N I I L L SL EL+L Sbjct: 281 DIAPLASLKSLTELQLSRNQISDIAPLESLNSLSKLWLNGNQITDIAPLASLNSLTELEL 340 Query: 128 YDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQ 187 NQI I L +L L L +S N + +I + L L +L L +N+IS I L++L+ Sbjct: 341 SSNQITDIAPLASLKSLSTLWLSSNQISDIAPLASLESLSELSLSSNQISDISPLASLNS 400 Query: 188 LQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDAL 229 L ++ N I+ + T ++E L+ + + D Sbjct: 401 LTGFDVRRNPIKRLPETITGFDMEILWNDFSSSGFITFFDNP 442 >6O00-A nrPDB Length = 820 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 74/312 (23%), Positives = 141/312 (45%), Gaps = 15/312 (4%) Query: 64 ELPVDMETINLDRDAE---DVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQ 120 E+P+ + ++ + ++ + R I+G LK++K L L+ NL K + + ++ Sbjct: 507 EIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVG 566 Query: 121 -SLRELDLYD--NQIKKIENLEALTELEILDI-SFNLLRNIEGVDKLTRLKKLFLVNNKI 176 L++L + + ++ + +L+ + L L++ +L R + L L+++ L +N + Sbjct: 567 VHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNL 626 Query: 177 SKIEN---LSNLHQLQMLELGSNRIRAIE-NIDTLTNLESLFLGKNKITKLQN-LDALTN 231 IE +LH+L L+L N I I I LTNLE L+L +NKI K+ L Sbjct: 627 KTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRK 686 Query: 232 LTVLSMQSNRLTKIEG-LQNLVNLRELYLSHNGIEVIEG-LENNNKLTMLDIASNRIKKI 289 L L + N LT + + L NL+ L ++ N IE + L KL L + +N ++ + Sbjct: 687 LRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSL 746 Query: 290 EN-ISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALP 348 + + LT L + + N LE + +E + P ++ + Sbjct: 747 PSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFSTLPPEVKERLWRAD 806 Query: 349 SVRQIDATFVRF 360 + ++ V F Sbjct: 807 KEQASNSLEVLF 818 >4R6F-A nrPDB Length = 331 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 82/293 (27%), Positives = 129/293 (44%), Gaps = 37/293 (12%) Query: 68 DMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDL 127 D T N + + N+ I ++G + L V+ L L N + I L+EL +L L+L Sbjct: 33 DAVTQNELNSIDQIIANNSDIKSVQGIQYLPNVRYLALGGNKLHDISALKELTNLGWLNL 92 Query: 128 YDNQIKKIEN--LEALTELEILDISFNLLRNIEG--VDKLTRLKKLFLVNNKISKIEN-- 181 +NQ++ + E LT L L++S N L ++ ++L L L L NN I+ I + Sbjct: 93 SNNQLETLPQGVFEKLTNLTTLNLSNNQLTSLPQGVFERLASLTTLNLSNNNIANINDQM 152 Query: 182 LSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNR 241 L L L L L N NL L+ N + L LTNLT L++ SN Sbjct: 153 LEGLTNLTTLNLSHN------------NLARLWKHANPGGPIYFLKGLTNLTTLNLSSNG 200 Query: 242 LTKIE--GLQNLVNLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKKIENISHLTE 297 +I ++L +L L LS+N I I LE LT L+++ N + + Sbjct: 201 FDEIPREVFKDLTSLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLAR--------- 251 Query: 298 LQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSV 350 W + N + LKG +L T+ L N + P+ K + +L ++ Sbjct: 252 ---LWKHAN---PGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTL 298 Score = 104 bits (259), Expect = 6e-23, Method: Composition-based stats. Identities = 57/225 (25%), Positives = 103/225 (45%), Gaps = 21/225 (9%) Query: 132 IKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQML 191 IK+I +A E ++ + + ++L + ++ N+ I ++ + L ++ L Sbjct: 9 IKQIFPDDAFAETIKANLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQYLPNVRYL 68 Query: 192 ELGSNRIRAIENIDTLTNLESLFLGKNKITKLQN--LDALTNLTVLSMQSNRLTKIE--G 247 LG N++ I + LTNL L L N++ L + LTNLT L++ +N+LT + Sbjct: 69 ALGGNKLHDISALKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQLTSLPQGV 128 Query: 248 LQNLVNLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKKIENISHLTELQEFWMND 305 + L +L L LS+N I I LE LT L+++ N + + W + Sbjct: 129 FERLASLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLAR------------LWKHA 176 Query: 306 NLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSV 350 N + LKG +L T+ L N + P+ K + +L ++ Sbjct: 177 N---PGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTL 218 Score = 85.2 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 52/194 (26%), Positives = 84/194 (43%), Gaps = 28/194 (14%) Query: 79 EDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKC----------IENLEELQSLRELDLY 128 ++ N+ + E L + TL L N + I L+ L +L L+L Sbjct: 138 LNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLS 197 Query: 129 DNQIKKIEN--LEALTELEILDISFNLLRNI--EGVDKLTRLKKLFLVNNKISKIENLSN 184 N +I + LT L L++S N + NI + ++ LT L L L +N ++++ +N Sbjct: 198 SNGFDEIPREVFKDLTSLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHAN 257 Query: 185 ----------LHQLQMLELGSNRIRAIE--NIDTLTNLESLFLGKNKITKLQN--LDALT 230 L L L L SN I LT+L +L L N++T L + LT Sbjct: 258 PGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNQLTSLPQGVFERLT 317 Query: 231 NLTVLSMQSNRLTK 244 NL L++ +N+L Sbjct: 318 NLKTLNLSNNQLQS 331 Score = 55.5 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 33/158 (20%), Positives = 66/158 (41%), Gaps = 3/158 (1%) Query: 195 SNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNL 254 S I+ I D L K +T + L ++ + ++ + ++G+Q L N+ Sbjct: 6 STPIKQIFPDDAFAETIKANLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQYLPNV 65 Query: 255 RELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIEN--ISHLTELQEFWMNDNLLESWS 312 R L L N + I L+ L L++++N+++ + LT L +++N L S Sbjct: 66 RYLALGGNKLHDISALKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQLTSLP 125 Query: 313 DLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSV 350 + SL T+ L N + + + L ++ Sbjct: 126 Q-GVFERLASLTTLNLSNNNIANINDQMLEGLTNLTTL 162 >3J0A-A nrPDB Length = 844 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 67/260 (25%), Positives = 110/260 (42%), Gaps = 39/260 (15%) Query: 80 DVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQ----------SLRELDLYD 129 D+ NH I + + F+ L+K++TL LR N + I + + +L +++L Sbjct: 344 DLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTA 403 Query: 130 NQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI---ENLSNLH 186 N I EN LE LDI + LLR + L+ L L N+ S + S Sbjct: 404 NLIHLSEN-----RLENLDILYFLLR-------VPHLQILILNQNRFSSCSGDQTPSENP 451 Query: 187 QLQMLELGSNRIR-------AIENIDTLTNLESLFLGKNKITKLQN--LDALTNLTVLSM 237 L+ L LG N ++ + + L++L+ L+L N + L LT L LS+ Sbjct: 452 SLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSL 511 Query: 238 QSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTE 297 SNRLT + NL L +S N + + + L++LDI N+ +S Sbjct: 512 NSNRLTVLSHNDLPANLEILDISRNQL-LAPNPDVFVSLSVLDITHNKFICECELSTFIN 570 Query: 298 LQEFWMNDNLLESWSDLDEL 317 W+N + ++ Sbjct: 571 ----WLNHTNVTIAGPPADI 586 Score = 76.7 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 56/295 (18%), Positives = 107/295 (36%), Gaps = 45/295 (15%) Query: 77 DAEDVDLNHYRIGKIEGFEVL--KKVKTLCLRQNLI---------KCIENLEELQSLREL 125 + D N + E L K + L N + KC+ + L L Sbjct: 151 KSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMV-LEIL 209 Query: 126 DLY------------DNQIKKIENLEALTELEIL-------DISFNLLRNIEGVDKLTRL 166 D+ N I K + + I+ +I G+ + + + Sbjct: 210 DVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLAR-SSV 268 Query: 167 KKLFLVNNKISKIEN--LSNLHQLQMLELGSNRIRAI--ENIDTLTNLESLFLGKNKITK 222 + L L + + + + L L++L L N+I I E L NL+ L L N + + Sbjct: 269 RHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGE 328 Query: 223 LQN--LDALTNLTVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGIEVIEGLENNNKLTM 278 L + L + + +Q N + I+ + L L+ L L N + I + + + Sbjct: 329 LYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIF- 387 Query: 279 LDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPL 333 ++ N++ + I+ L +++N LE+ L L L+ + L +N Sbjct: 388 --LSGNKLVTLPKINLTANL--IHLSENRLENLDILYFLLRVPHLQILILNQNRF 438 Score = 74.8 bits (182), Expect = 5e-14, Method: Composition-based stats. Identities = 67/378 (17%), Positives = 122/378 (32%), Gaps = 109/378 (28%) Query: 89 GKIEGFEVLKKVKTLCLRQNLIKCIEN----------------------------LEELQ 120 E F L ++ L L + I + L+ Sbjct: 64 IDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLK 123 Query: 121 SLRELDLYDNQIKKI---ENLEALTELEILDISFNLLRNI--EGVDKLT--RLKKLFLVN 173 +L LDL NQI+ + + L L+ +D S N + + ++ L L L Sbjct: 124 ALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAA 183 Query: 174 NKISK---------IENLSNLHQLQMLELGSNRIR------------------------- 199 N + + N+ L++L++ N Sbjct: 184 NSLYSRVSVDWGKCMNPFRNMV-LEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHI 242 Query: 200 -----AIENIDTL----------TNLESLFLGKNKITKLQN--LDALTNLTVLSMQSNRL 242 NI +++ L L + L + + L +L VL++ N++ Sbjct: 243 MGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKI 302 Query: 243 TKI--EGLQNLVNLRELYLSHNGIEVI--EGLENNNKLTMLDIASNRIKKIEN--ISHLT 296 KI E L NL+ L LS+N + + K+ +D+ N I I++ L Sbjct: 303 NKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLE 362 Query: 297 ELQEFWMNDNLLESWSDLDELK----GARSLETV----------YLERNPLQKDPQYRRK 342 +LQ + DN L + + + L T+ +L N L+ Sbjct: 363 KLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENL--DILY 420 Query: 343 VMLALPSVRQIDATFVRF 360 +L +P ++ + RF Sbjct: 421 FLLRVPHLQILILNQNRF 438 Score = 47.1 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 45/205 (21%), Positives = 73/205 (35%), Gaps = 32/205 (15%) Query: 139 EALTELEILDISFNLLRNIEGV-DKLTRLKKLFLVNNKISKI----ENLSNLHQLQMLEL 193 + L E L +SFN +R + +L + ++ + + E NL L++L+L Sbjct: 21 QVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDL 80 Query: 194 GSNRIRAIEN--IDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNL 251 GS++I + L +L L L ++ D +NL Sbjct: 81 GSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGY------------------FRNL 122 Query: 252 VNLRELYLSHNGIEVI---EGLENNNKLTMLDIASNRIKKIENISHLT----ELQEFWMN 304 L L LS N I + N L +D +SN+I + L F + Sbjct: 123 KALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLA 182 Query: 305 DNLLESWSDLDELKGARSLETVYLE 329 N L S +D K + LE Sbjct: 183 ANSLYSRVSVDWGKCMNPFRNMVLE 207 >5LFN-A nrPDB Length = 337 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 77/282 (27%), Positives = 127/282 (45%), Gaps = 27/282 (9%) Query: 82 DLNHYRIGKIEGFEVLKKV----KTLCLRQNLIKCIE--NLEELQSLRELDLYDNQIKKI 135 DL H K+ G + + KV K L L++N + + + +L L L QI+++ Sbjct: 10 DLQHVICDKV-GLQKIPKVSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREV 68 Query: 136 EN--LEALTELEILDISFNLLRNIEG--VDKLTRLKKLFLVNNKISKIEN--LSNLHQLQ 189 L +L L +S N +R + D LT L L+L +NK++++ LS L L Sbjct: 69 AAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLF 128 Query: 190 MLELGSNRIRAIEN--IDTLTNLESLFLGKNKITKLQN--LDALTNLTVLSMQSNRLTKI 245 +L+L +N+IR + +L L+L +N ++ LQ LD + NL + N+L+ Sbjct: 129 ILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSY 188 Query: 246 E--GLQNLVNLRELYLSHNGIEVIEG---LENNNKLTMLDIASNRIKKIENISHL--TEL 298 L L + EL LSHN ++ I L L + + ++K + + L T L Sbjct: 189 PSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTL 248 Query: 299 QEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYR 340 + + +N L SLET+ L NP + Q R Sbjct: 249 KHVHLENNRLNQLPSNFPF---DSLETLALTNNPWKCTCQLR 287 Score = 101 bits (251), Expect = 6e-22, Method: Composition-based stats. Identities = 60/231 (25%), Positives = 103/231 (44%), Gaps = 12/231 (5%) Query: 132 IKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI--ENLSNLHQLQ 189 ++KI + T+L L + + + L L L + +I ++ L QL Sbjct: 21 LQKIPKVSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLI 80 Query: 190 MLELGSNRIRAIEN--IDTLTNLESLFLGKNKITKLQN--LDALTNLTVLSMQSNRLTKI 245 L L N IR + D LT L L+L NK+T+L L L NL +L + +N++ ++ Sbjct: 81 YLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIREL 140 Query: 246 EG--LQNLVNLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKKIEN--ISHLTELQ 299 Q +LR LYLS N + ++ L++ L + N++ + +S L ++ Sbjct: 141 RAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVE 200 Query: 300 EFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSV 350 E ++ N L+S D R LET++L+ L+K + L V Sbjct: 201 ELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHV 251 Score = 72.1 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 41/207 (19%), Positives = 86/207 (41%), Gaps = 35/207 (16%) Query: 81 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQIKKIEN- 137 + N R+ + F+ L ++ L L N + + L L +L L L +N+I+++ Sbjct: 84 LSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAG 143 Query: 138 -LEALTELEILDISFNLLRNIE--GVDKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLE 192 + +L L +S N L +++ +D + L K + N++S + LS L ++ L+ Sbjct: 144 AFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELK 203 Query: 193 LGSNRIRAIEN---------------------------IDTLTNLESLFLGKNKITKLQN 225 L N +++I + +T L+ + L N++ +L + Sbjct: 204 LSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPS 263 Query: 226 LDALTNLTVLSMQSNRLTKIEGLQNLV 252 +L L++ +N L+ L Sbjct: 264 NFPFDSLETLALTNNPWKCTCQLRGLR 290 Score = 69.4 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 37/162 (22%), Positives = 75/162 (46%), Gaps = 11/162 (6%) Query: 81 VDLNHYRIGKIEG--FEVLKKVKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQIKKIE 136 + LN+ +I ++ F+ K ++ L L +N + ++ L+++++L + + NQ+ Sbjct: 130 LQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYP 189 Query: 137 N--LEALTELEILDISFNLLRNIE--GVDKLTR-LKKLFLVNNKISKIEN--LSNLHQLQ 189 + L L +E L +S N L++I R L+ L+L N + K + + L+ Sbjct: 190 SAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLK 249 Query: 190 MLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTN 231 + L +NR+ + + +LE+L L N L L Sbjct: 250 HVHLENNRLNQLPSNFPFDSLETLALTNNPWKCTCQLRGLRR 291 Score = 67.5 bits (163), Expect = 8e-12, Method: Composition-based stats. Identities = 38/166 (22%), Positives = 69/166 (41%), Gaps = 7/166 (4%) Query: 188 LQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIE- 246 LQ + ++ I + T L +L + + A+ NL L +Q ++ ++ Sbjct: 11 LQHVICDKVGLQKIPKVSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAA 70 Query: 247 -GLQNLVNLRELYLSHNGIEVIE--GLENNNKLTMLDIASNRIKKIEN--ISHLTELQEF 301 + L L LYLSHN I V+ ++ +LT L + N++ ++ +S L L Sbjct: 71 GAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFIL 130 Query: 302 WMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLAL 347 +N+N + +GA+ L +YL N L + L Sbjct: 131 QLNNNKIREL-RAGAFQGAKDLRWLYLSENALSSLQPGALDDVENL 175 >6GFF-I nrPDB Length = 618 Score = 152 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 70/295 (23%), Positives = 116/295 (39%), Gaps = 45/295 (15%) Query: 97 LKKVKTLCLRQNLIKCI--ENLEELQSLRELDLYDNQIKKIEN--LEALTELEILDISFN 152 +TL L N ++ I L +LR LDL N+I ++ +ALT LE L ++ N Sbjct: 29 PPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHN 88 Query: 153 LLR-----NIEGVDKLTRLKKLFLVNNKISK--IENL-SNLHQLQMLELGSNRIRAI--E 202 L + G+ L R+ L L N + +E L L L L N + + Sbjct: 89 RLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRH 148 Query: 203 NIDTLTNLESLFLGKNKITKLQN--LDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLS 260 + LE L L N + +++ + L LT L++ N LT I +L LR L LS Sbjct: 149 TFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDF-SLQQLRVLDLS 207 Query: 261 HNGIEVIEGLENNN---KLTMLDIASNRIKKIENISHLTELQEFWMNDNLL--------- 308 N IE + +LT LD+ N++ +++ L L +++NL+ Sbjct: 208 CNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQD 267 Query: 309 ----------------ESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLAL 347 + S + L + L N ++ P + + +L Sbjct: 268 SKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSL 322 Score = 110 bits (275), Expect = 8e-25, Method: Composition-based stats. Identities = 73/284 (25%), Positives = 115/284 (40%), Gaps = 25/284 (8%) Query: 77 DAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIE 136 + D+ N + FE L ++ L L +N + CI + LQ LR LDL N I+ + Sbjct: 157 EQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFS-LQQLRVLDLSCNSIEAFQ 215 Query: 137 NL---EALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLS------NLHQ 187 +A +L LD+ N L + + L RL L L NN I + Sbjct: 216 TASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPS 275 Query: 188 LQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQN--LDALTNLTVLSMQSNRLTKI 245 L + + L+ L +L L N+I + + L+ LT+L L++ N L Sbjct: 276 EGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTF 335 Query: 246 EG--LQNLVNLRELYLSHNGIEVIE-GLENNNKLTMLDIASNRIKKIEN--ISHLTELQE 300 E L +L L L LSHN +E +E G L L + N ++ + ++L LQ Sbjct: 336 EARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQR 395 Query: 301 FWMNDNLLESWSDLDE--------LKGARSLETVYLERNPLQKD 336 + N + DE G SL ++ L N ++ Sbjct: 396 LNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELL 439 Score = 103 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 76/264 (28%), Positives = 112/264 (42%), Gaps = 23/264 (8%) Query: 95 EVLKKVKTLCLRQNLIKCI--ENLEELQSLRELDLYDNQIKKIEN--LEALTELEILDIS 150 L ++ L L N I+ I LE L SL L+L N ++ E L +L L +LD+S Sbjct: 293 RPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLS 352 Query: 151 FNLLRNIE-GVDKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRIRAIE----- 202 N L +E G L L+ L L N + + +NL LQ L L NR+ Sbjct: 353 HNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEP 412 Query: 203 ------NIDTLTNLESLFLGKNKITKLQNLDAL-TNLTVLSMQSNRLTKIE--GLQNL-V 252 +T+L SL L N+I L+ L T LT L + SN ++ L L Sbjct: 413 GPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEA 472 Query: 253 NLRELYLSHNGIEVIE-GLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESW 311 +L L L NG+ V++ L L L++A NR+ + + L+ + +N Sbjct: 473 SLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLL 532 Query: 312 SDLDELKGARSLETVYLERNPLQK 335 SL +YL+ NPL Sbjct: 533 PGSAMGGLETSLRRLYLQGNPLSC 556 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 33/135 (24%), Positives = 53/135 (39%), Gaps = 12/135 (8%) Query: 229 LTNLTVLSMQSNRLTKI--EGLQNLVNLRELYLSHNGIEVIEG--LENNNKLTMLDIASN 284 + L + N+L I L LR L LS N I ++ + L L +A N Sbjct: 29 PPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHN 88 Query: 285 RIKKIE-----NISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQY 339 R+ + L + ++ N L S L A SL T+ L N L + ++ Sbjct: 89 RLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRH 148 Query: 340 RRKVMLALPSVRQID 354 + M P++ Q+D Sbjct: 149 TFRDM---PALEQLD 160 >1JL5-A nrPDB Length = 454 Score = 151 bits (381), Expect = 5e-37, Method: Composition-based stats. Identities = 78/332 (23%), Positives = 149/332 (44%), Gaps = 57/332 (17%) Query: 61 EEHELPVDMETINLDRDAEDVDLNHYRIGKI------------------EGFEVLKKVKT 102 E+ E+ V LDR A +++LN+ + + E E+ + +K+ Sbjct: 56 EQREMAVSRLRDCLDRQAHELELNNLGLSSLPELPPHLESLVASCNSLTELPELPQSLKS 115 Query: 103 LCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDK 162 L + N +K + +L L L L + +NQ++K+ L+ + L+I+D+ N L+ + D Sbjct: 116 LLVDNNNLKALSDLPPL--LEYLGVSNNQLEKLPELQNSSFLKIIDVDNNSLKKLP--DL 171 Query: 163 LTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITK 222 L+ + NN++ ++ L NL L + +N ++ + D +LES+ G N + + Sbjct: 172 PPSLEFIAAGNNQLEELPELQNLPFLTAIYADNNSLKKLP--DLPLSLESIVAGNNILEE 229 Query: 223 LQNLDALTNLTVLSMQSNRLTKIEGLQN-----------LVNLRELYLSHNGIEVIEGL- 270 L L L LT + +N L + L L +L EL S ++V E + Sbjct: 230 LPELQNLPFLTTIYADNNLLKTLPDLPPSLEALNVRDNYLTDLPELPQSLTFLDVSENIF 289 Query: 271 ----ENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDN--------------LLESWS 312 E L L+ +SN I+ + ++ L+E +++N L+ S++ Sbjct: 290 SGLSELPPNLYYLNASSNEIRSLCDLP--PSLEELNVSNNKLIELPALPPRLERLIASFN 347 Query: 313 DLDELKGAR-SLETVYLERNPLQKDPQYRRKV 343 L E+ +L+ +++E NPL++ P V Sbjct: 348 HLAEVPELPQNLKQLHVEYNPLREFPDIPESV 379 Score = 69.4 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 42/166 (25%), Positives = 77/166 (46%), Gaps = 9/166 (5%) Query: 192 ELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNL 251 EL N + + +LESL N +T+L L +L L + +N L + L L Sbjct: 75 ELELNNLGLSSLPELPPHLESLVASCNSLTELPELP--QSLKSLLVDNNNLKALSDLPPL 132 Query: 252 VNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESW 311 L L +S+N +E + L+N++ L ++D+ +N +KK+ ++ L+ +N LE Sbjct: 133 --LEYLGVSNNQLEKLPELQNSSFLKIIDVDNNSLKKLPDLP--PSLEFIAAGNNQLE-- 186 Query: 312 SDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDATF 357 +L EL+ L +Y + N L+K P + + ++ Sbjct: 187 -ELPELQNLPFLTAIYADNNSLKKLPDLPLSLESIVAGNNILEELP 231 >4R08-A nrPDB Length = 811 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 65/280 (23%), Positives = 114/280 (40%), Gaps = 36/280 (12%) Query: 77 DAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIEN---LEELQSLRELDLYDNQIK 133 A D+ LN FE L + L L N + + + ++ LDL +N++ Sbjct: 462 KALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLD 521 Query: 134 K--IENLEALTELEILDISFNL--------LRNIEGVDKLTRLKKLFLVNNKISKIENLS 183 L L++LE+LD+S+N ++E + T LK L L +N I + + Sbjct: 522 FDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKY 581 Query: 184 NLHQLQMLEL--GSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNR 241 NL ++EL NR+ + N D + L NLT L + NR Sbjct: 582 NLESKSLVELVFSGNRLDILWNDDDNRY-------------ISIFKGLKNLTRLDLSLNR 628 Query: 242 LTKIEG---LQNLVNLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKKIEN--ISH 294 L I L +L EL+++ N ++ L+ +L +LD+ N++ + + Sbjct: 629 LKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDF 688 Query: 295 LTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQ 334 + L+ ++ N + L SL+ + L N L+ Sbjct: 689 TSSLRTLLLSHNRISHLPS-GFLSEVSSLKHLDLSSNLLK 727 Score = 79.0 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 83/382 (21%), Positives = 145/382 (37%), Gaps = 80/382 (20%) Query: 33 KKHSSGIVADLSEQSLKDGEERGEEDPEEEHELPVDMETINLDRDAEDVDLNHYRIGKIE 92 KK + ++A+ S + L+ E+P +T+ D+ N E Sbjct: 17 KKQNDSVIAECSNRRLQ--------------EVP---QTVGKYVTELDLSDNFITHITNE 59 Query: 93 GFEVLKKVKTLCLRQN-----------------LIKCIENLEELQSLRELDLYDNQIKKI 135 F+ L+ + + L N I L L++LREL L DNQ+ +I Sbjct: 60 SFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFL-NLKNLRELLLEDNQLPQI 118 Query: 136 ENLEALTELEILDISFNLLRNI--EGVDKLTRLKKLFLVNN-------KISKIEN--LSN 184 + L L + N + NI EG+ +L LK L+L N + + IE+ Sbjct: 119 PS-GLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFET 177 Query: 185 LHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKL--QNLDALTNLTVLSMQSN-- 240 L L++L L N + + ++L LFL +I + ++ L NLT+L + N Sbjct: 178 LTNLELLSLSFNSLSHVPP-KLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCP 236 Query: 241 -----RLTKIEG------------LQNLVNLRELYLSHNGIEVIE--GLENNNKLTMLDI 281 + QNL LR L LS + I +N L +LD+ Sbjct: 237 RCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDL 296 Query: 282 ASN----RIKKIENISHLTELQEFWMNDNLL-----ESWSDLDELKGARSLETVYLERNP 332 N I ++ L L+ ++ N + + + SL ++L Sbjct: 297 EFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYV 356 Query: 333 LQKDPQYRRKVMLALPSVRQID 354 Q+ + + ++ LP++ I+ Sbjct: 357 FQELREDDFQPLMQLPNLSTIN 378 Score = 71.3 bits (173), Expect = 6e-13, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 109/295 (36%), Gaps = 37/295 (12%) Query: 61 EEHELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQN-LIKCIENLEEL 119 E+++LP + + N+ EG L +K L L N + + Sbjct: 111 EDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNI 170 Query: 120 QSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI 179 + E LT LE+L +SFN L ++ + L+KLFL N +I I Sbjct: 171 EDGV--------------FETLTNLELLSLSFNSLSHVPP-KLPSSLRKLFLSNTQIKYI 215 Query: 180 --ENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSM 237 E+ L L +L+L N R + G + LT L L++ Sbjct: 216 SEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDG---GASINIDRFAFQNLTQLRYLNL 272 Query: 238 QSNRLTKIEG--LQNLVNLRELYLSHN----GIEVIEGLENNNKLTMLDIASNRIK-KIE 290 S L KI +N+ +L+ L L N I L +L +LD++ N IK Sbjct: 273 SSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYP 332 Query: 291 -------NISHLTELQEFWMNDNLLESW--SDLDELKGARSLETVYLERNPLQKD 336 N S L L+ + + + D L +L T+ L N +++ Sbjct: 333 QHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQI 387 Score = 66.7 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 55/218 (25%), Positives = 87/218 (39%), Gaps = 44/218 (20%) Query: 93 GFEVLKKVKTLCLRQNLIKCIE--NLEELQSLRELDLYDN-------------------- 130 ++ ++ L L IK I + + L +L LDL N Sbjct: 195 PPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASI 254 Query: 131 QIKKIENLEALTELEILDISFNLLRNIEG--VDKLTRLKKLFLVNN----KISKIENLSN 184 I + + LT+L L++S LR I + LK L L N +I+ L+ Sbjct: 255 NIDRFA-FQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTM 313 Query: 185 LHQLQMLELGSN--------RIRAIENIDTLTNLESLFLGKNKITKL-----QNLDALTN 231 L +L++L+L N I N L +L +L L +L Q L L N Sbjct: 314 LPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPN 373 Query: 232 LTVLSMQSNRLTKIE--GLQNLVNLRELYLSHNGIEVI 267 L+ +++ N + +I+ QN NL +YLS N I + Sbjct: 374 LSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPL 411 >1M9S-A nrPDB Length = 605 Score = 138 bits (347), Expect = 4e-33, Method: Composition-based stats. Identities = 61/172 (35%), Positives = 95/172 (55%) Query: 68 DMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDL 127 D T N + + N+ I ++G + L V L L N + I+ L L++L L L Sbjct: 35 DAVTQNELNSIDQIIANNSDIKSVQGIQYLPNVTKLFLNGNKLTDIKPLTNLKNLGWLFL 94 Query: 128 YDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQ 187 +N+IK + +L+ L +L+ L + N + +I G+ L +L+ L+L NNKI+ I LS L + Sbjct: 95 DENKIKDLSSLKDLKKLKSLSLEHNGISDINGLVHLPQLESLYLGNNKITDITVLSRLTK 154 Query: 188 LQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQS 239 L L L N+I I + LT L++L+L KN I+ L+ L L NL VL + S Sbjct: 155 LDTLSLEDNQISDIVPLAGLTKLQNLYLSKNHISDLRALAGLKNLDVLELFS 206 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 53/182 (29%), Positives = 88/182 (48%), Gaps = 22/182 (12%) Query: 126 DLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNL 185 +L + L ++ + + + +++++G+ L + KLFL NK++ I+ L+NL Sbjct: 27 NLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQYLPNVTKLFLNGNKLTDIKPLTNL 86 Query: 186 HQLQMLELGSNRIR-------------------AIENIDTLTN---LESLFLGKNKITKL 223 L L L N+I+ I +I+ L + LESL+LG NKIT + Sbjct: 87 KNLGWLFLDENKIKDLSSLKDLKKLKSLSLEHNGISDINGLVHLPQLESLYLGNNKITDI 146 Query: 224 QNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIAS 283 L LT L LS++ N+++ I L L L+ LYLS N I + L L +L++ S Sbjct: 147 TVLSRLTKLDTLSLEDNQISDIVPLAGLTKLQNLYLSKNHISDLRALAGLKNLDVLELFS 206 Query: 284 NR 285 Sbjct: 207 QE 208 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 63/227 (27%), Positives = 110/227 (48%), Gaps = 3/227 (1%) Query: 132 IKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQML 191 IK+I +A E ++ + + ++L + ++ N+ I ++ + L + L Sbjct: 11 IKQIFPDDAFAETIKDNLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQYLPNVTKL 70 Query: 192 ELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNL 251 L N++ I+ + L NL LFL +NKI L +L L L LS++ N ++ I GL +L Sbjct: 71 FLNGNKLTDIKPLTNLKNLGWLFLDENKIKDLSSLKDLKKLKSLSLEHNGISDINGLVHL 130 Query: 252 VNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESW 311 L LYL +N I I L KL L + N+I I ++ LT+LQ +++ N + Sbjct: 131 PQLESLYLGNNKITDITVLSRLTKLDTLSLEDNQISDIVPLAGLTKLQNLYLSKNHI--- 187 Query: 312 SDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDATFV 358 SDL L G ++L+ + L P + ++ +V+ D + V Sbjct: 188 SDLRALAGLKNLDVLELFSQECLNKPINHQSNLVVPNTVKNTDGSLV 234 Score = 56.7 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 39/201 (19%), Positives = 75/201 (37%), Gaps = 49/201 (24%) Query: 195 SNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNL 254 S I+ I D L K +T + L ++ + ++ + ++G+Q L N+ Sbjct: 8 STPIKQIFPDDAFAETIKDNLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQYLPNV 67 Query: 255 RELYLSHNGIEVIEGLENNNKLTMLDIASNRIK----------------------KIENI 292 +L+L+ N + I+ L N L L + N+IK I + Sbjct: 68 TKLFLNGNKLTDIKPLTNLKNLGWLFLDENKIKDLSSLKDLKKLKSLSLEHNGISDINGL 127 Query: 293 SHLTELQEFWMNDNLLE-------------------SWSDLDELKGARSLETVYLERNPL 333 HL +L+ ++ +N + SD+ L G L+ +YL +N + Sbjct: 128 VHLPQLESLYLGNNKITDITVLSRLTKLDTLSLEDNQISDIVPLAGLTKLQNLYLSKNHI 187 Query: 334 QKDPQYRRKVMLALPSVRQID 354 + AL ++ +D Sbjct: 188 --------SDLRALAGLKNLD 200 >5MX0-A nrPDB Length = 362 Score = 137 bits (345), Expect = 6e-33, Method: Composition-based stats. Identities = 51/200 (25%), Positives = 91/200 (45%), Gaps = 14/200 (7%) Query: 145 EILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRIR--- 199 + L+ + V R+K ++ NN+I+ I+ N L + L N+I Sbjct: 74 TAMYCDNRNLKYLPFVPS--RMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDK 131 Query: 200 -AIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIE--GLQNLVNLRE 256 + L +LE L+L N +T++ +L L + N+++++ L+ L NL Sbjct: 132 VGRKVFSKLRHLERLYLDHNNLTRMPG-PLPRSLRELHLDHNQISRVPNNALEGLENLTA 190 Query: 257 LYLSHNGI-EVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLD 315 LYL HN I EV + L +LD++ N ++K+ + + L++ +M N + + D Sbjct: 191 LYLQHNEIQEVGSSMRGLRSLILLDLSYNHLRKVPD-GLPSALEQLYMEHNNVYTVPD-S 248 Query: 316 ELKGARSLETVYLERNPLQK 335 +GA L V L N L Sbjct: 249 YFRGAPKLLYVRLSHNSLTN 268 Score = 97.1 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 61/260 (23%), Positives = 116/260 (44%), Gaps = 25/260 (9%) Query: 97 LKKVKTLCLRQNLIKCIE--NLEELQSLRELDLYDNQIKK----IENLEALTELEILDIS 150 ++K + + N I I+ + L + L+ NQI + L LE L + Sbjct: 90 PSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLYLD 149 Query: 151 FNLLRNIEGVDKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRIRAI-ENIDTL 207 N L + G L++L L +N+IS++ N L L L L L N I+ + ++ L Sbjct: 150 HNNLTRMPG-PLPRSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQEVGSSMRGL 208 Query: 208 TNLESLFLGKNKITKLQNLDALTN-LTVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGI 264 +L L L N + K+ D L + L L M+ N + + + L + LSHN + Sbjct: 209 RSLILLDLSYNHLRKVP--DGLPSALEQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNSL 266 Query: 265 E---VIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWS-----DLDE 316 + N++ L LD++ N+++KI ++ T L+ ++ N + +S + + Sbjct: 267 TNNGLASNTFNSSSLLELDLSYNQLQKIPPVN--TNLENLYLQGNRINEFSISSFCTVVD 324 Query: 317 LKGARSLETVYLERNPLQKD 336 + L+ + L+ N +++ Sbjct: 325 VVNFSKLQVLRLDGNEIKRS 344 Score = 35.9 bits (81), Expect = 0.026, Method: Composition-based stats. Identities = 29/140 (20%), Positives = 48/140 (34%), Gaps = 19/140 (13%) Query: 77 DAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIK---CIENLEELQSLRELDLYDNQIK 133 + ++ N+ F K+ + L N + N SL ELDL NQ++ Sbjct: 233 EQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNSLTNNGLASNTFNSSSLLELDLSYNQLQ 292 Query: 134 KIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLEL 193 KI + T LE L + N + + + ++ N +LQ+L L Sbjct: 293 KIPPVN--TNLENLYLQGNRINE--------------FSISSFCTVVDVVNFSKLQVLRL 336 Query: 194 GSNRIRAIENIDTLTNLESL 213 N I+ L Sbjct: 337 DGNEIKRSAMPADAPLCLRL 356 >5ZSN-B nrPDB Length = 823 Score = 132 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 80/308 (25%), Positives = 124/308 (40%), Gaps = 64/308 (20%) Query: 89 GKIEGFEVLKKVKTLCLRQNLIKCIEN-----------------------LEELQSLREL 125 K F L +K+L L N + I L EL ++ L Sbjct: 96 IKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKEQLTELANIEIL 155 Query: 126 DLYDN-----------QIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNN 174 L N I+K + LT+L++L + N + + V T L +L+L NN Sbjct: 156 YLGQNCYYRNPCYVSYSIEK-DAFLNLTKLKVLSLKDNNVTTVPTVLPST-LTELYLYNN 213 Query: 175 KISKIE--NLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNL 232 I++I+ + +NL+QLQ+L+L N R T ++ + DALT L Sbjct: 214 MIAEIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCTPCKN---NSPLQIPVNAFDALTEL 270 Query: 233 TVLSMQSNRLTKIEG--LQNLVNLRELYLSHNG----IEVIEGLENNNKLTMLDIASNRI 286 VL + SN L + +N+ NL+EL LS N I + L L LD++ N Sbjct: 271 KVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFLAKEIGDAKFLHFLPNLIQLDLSFN-- 328 Query: 287 KKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLA 346 ELQ + + NL +++S L LK R V+ E Q P + Sbjct: 329 ---------FELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFQLSP------LHN 373 Query: 347 LPSVRQID 354 L ++ +D Sbjct: 374 LQNLEVLD 381 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 73/292 (25%), Positives = 116/292 (39%), Gaps = 33/292 (11%) Query: 77 DAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQS---LRELDLYDNQIK 133 D+ N K F+ L +K L L NLI N E Q LR LD +N++ Sbjct: 474 QTLDLSKNSIFFIKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLD 533 Query: 134 KIEN--LEALTELEILDISFNL--------LRNIEGVDKLTRLKKLFLVNNKI-SKIENL 182 + + E L +LE+LDIS N + L L+KL + +N I S Sbjct: 534 LLHSTAFEELRKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRT 593 Query: 183 SNLHQLQMLELGSNRIRAIEN---------IDTLTNLESLFLGKNKITKLQN--LDAL-T 230 L+ LE N + + L LE L + KN ++ L + D + Sbjct: 594 MESESLRTLEFRGNHLDVLWRDGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPP 653 Query: 231 NLTVLSMQSNRLTKI--EGLQNLVNLRELYLSHNGIEVIEGLENN--NKLTMLDIASNRI 286 NL LS+ N L E L+ L NL L LSHN + + +N L L + +N+I Sbjct: 654 NLKNLSLAKNGLKSFIWEKLRYLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQI 713 Query: 287 KKIEN--ISHLTELQEFWMNDNLLESWSDLDELKG-ARSLETVYLERNPLQK 335 + + + +L+ ++ N ++ + +L+ + L N Sbjct: 714 RSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLC 765 Score = 72.1 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 71/355 (20%), Positives = 124/355 (34%), Gaps = 86/355 (24%) Query: 64 ELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIK----CIENLEEL 119 ++PV+ + + N + F+ + ++ L L QN + + L L Sbjct: 258 QIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFLAKEIGDAKFLHFL 317 Query: 120 QSLRELDLYDN--------QIKKIENLEALTELEILDISFNLLRNIEGVD-----KLTRL 166 +L +LDL N + + +L L+IL I + + ++ L L Sbjct: 318 PNLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFQLSPLHNLQNL 377 Query: 167 KKLFLVNN--KISKIENLSNLHQLQMLELGSNRIRAIENIDTLTN--------------- 209 + L L N KI+ + +L++++L N+I + Sbjct: 378 EVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSLVPRGSSNARTSVESYEPQV 437 Query: 210 LESLF-----------------------------------LGKNKI--TKLQNLDALTNL 232 LE L+ L KN I K + L+ L Sbjct: 438 LEQLYYFRYDKYARSCRFKNKEASFTSVQESCYKYGQTLDLSKNSIFFIKSSDFQHLSFL 497 Query: 233 TVLSMQSNRLTKI---EGLQNLVNLRELYLSHNGIEVIEG--LENNNKLTMLDIASNR-- 285 L++ N +++ Q L LR L S+N ++++ E KL +LDI+SN Sbjct: 498 KCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELRKLEVLDISSNSHY 557 Query: 286 ------IKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQ 334 + +L LQ+ MNDN + S + SL T+ N L Sbjct: 558 FQSEGITHMLNFTKNLKVLQKLMMNDNDIS--SSTSRTMESESLRTLEFRGNHLD 610 Score = 70.6 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 62/303 (20%), Positives = 112/303 (36%), Gaps = 43/303 (14%) Query: 84 NHYRIGKIEGFEVLKKVKTLCLRQNLIKCIEN--LEELQSLRELDLYDN----QIKKIEN 137 N + F+ L ++K L L N ++ + + + +L+ELDL N +I + Sbjct: 254 NSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFLAKEIGDAKF 313 Query: 138 LEALTELEILDISFN--------LLRNIEGVDKLTRLKKLFLVNNKISKIENLS-----N 184 L L L LD+SFN + + L LK L + ++++ N Sbjct: 314 LHFLPNLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFQLSPLHN 373 Query: 185 LHQLQMLELGSN--RIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRL 242 L L++L+LG+N +I + L+ + L NKI+ + SN Sbjct: 374 LQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSLVPRG------SSNAR 427 Query: 243 TKIEGLQNLVNLRELYLSH-----------NGIEVIEGLEN--NNKLTMLDIASNRI--K 287 T +E + L +LY N ++ LD++ N I Sbjct: 428 TSVESYE-PQVLEQLYYFRYDKYARSCRFKNKEASFTSVQESCYKYGQTLDLSKNSIFFI 486 Query: 288 KIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLAL 347 K + HL+ L+ ++ NL+ + E + L + N L + + L Sbjct: 487 KSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELRKL 546 Query: 348 PSV 350 + Sbjct: 547 EVL 549 >2FT3-A nrPDB Length = 332 Score = 124 bits (312), Expect = 5e-29, Method: Composition-based stats. Identities = 69/259 (26%), Positives = 108/259 (41%), Gaps = 38/259 (14%) Query: 111 KCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNI--EGVDKLTRLKK 168 + LR + D +K + E + +LD+ N + + + L L Sbjct: 24 SAMCPFGCHCHLRVVQCSDLGLKAVPK-EISPDTTLLDLQNNDISELRKDDFKGLQHLYA 82 Query: 169 LFLVNNKISKI--ENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQN- 225 L LVNNKISKI + S L +LQ L + N + I + ++L L + N+I K+ Sbjct: 83 LVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPP-NLPSSLVELRIHDNRIRKVPKG 141 Query: 226 -LDALTNLTVLSMQSNRL----------------------TKIEGLQN--LVNLRELYLS 260 L N+ + M N L K+ G+ L EL+L Sbjct: 142 VFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETLNELHLD 201 Query: 261 HNGIEV--IEGLENNNKLTMLDIASNRIKKIEN--ISHLTELQEFWMNDNLLESWSDLDE 316 HN I+ +E L +KL L + N+I+ IEN +S L L+E +++N L Sbjct: 202 HNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLSRVP--AG 259 Query: 317 LKGARSLETVYLERNPLQK 335 L + L+ VYL N + K Sbjct: 260 LPDLKLLQVVYLHTNNITK 278 Score = 84.4 bits (207), Expect = 6e-17, Method: Composition-based stats. Identities = 60/229 (26%), Positives = 98/229 (42%), Gaps = 34/229 (14%) Query: 72 INLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIE-----NLEELQ------ 120 I+ D D+ N + + F+ L+ + L L N I I L +LQ Sbjct: 52 ISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISK 111 Query: 121 ------------SLRELDLYDNQIKKIEN--LEALTELEILDISFNLLRNI---EGVDKL 163 SL EL ++DN+I+K+ L + +++ N L N G Sbjct: 112 NHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDG 171 Query: 164 TRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTL--TNLESLFLGKNKIT 221 +L L + K++ I L L L N+I+AIE D L + L L LG N+I Sbjct: 172 LKLNYLRISEAKLTGIPKDLP-ETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIR 230 Query: 222 KLQ--NLDALTNLTVLSMQSNRLTKIEG-LQNLVNLRELYLSHNGIEVI 267 ++ +L L L L + +N+L+++ L +L L+ +YL N I + Sbjct: 231 MIENGSLSFLPTLRELHLDNNKLSRVPAGLPDLKLLQVVYLHTNNITKV 279 Score = 68.6 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 48/206 (23%), Positives = 86/206 (41%), Gaps = 58/206 (28%) Query: 81 VDLNHYRIGKI--EGFEVLKKVKTLCLRQN-LIKCIENLEELQSLRELDLYDNQIKKIEN 137 + L + +I KI + F L+K++ L + +N L++ NL SL EL ++DN+I+K+ Sbjct: 83 LVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPS--SLVELRIHDNRIRKVPK 140 Query: 138 --LEALTELEILDISFNLLRN--------------------------------------- 156 L + +++ N L N Sbjct: 141 GVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETLNELHL 200 Query: 157 ---------IEGVDKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRIRAIEN-I 204 +E + + ++L +L L +N+I IEN LS L L+ L L +N++ + + Sbjct: 201 DHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLSRVPAGL 260 Query: 205 DTLTNLESLFLGKNKITKLQNLDALT 230 L L+ ++L N ITK+ D Sbjct: 261 PDLKLLQVVYLHTNNITKVGVNDFCP 286 >5Y3M-A nrPDB Length = 801 Score = 121 bits (303), Expect = 5e-28, Method: Composition-based stats. Identities = 73/288 (25%), Positives = 118/288 (40%), Gaps = 31/288 (10%) Query: 79 EDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLE---ELQSLRELDLYDNQIKKI 135 D+ N+ + E F L +++ L L N I N L SLR LDL N++ Sbjct: 455 LDLSRNNLVTIQQEMFTRLSRLQCLRLSHNSISQAVNGSQFVPLTSLRVLDLSHNKLDLY 514 Query: 136 E--NLEALTELEILDISFNLL--------RNIEGVDKLTRLKKLFLVNNKI-SKIENLSN 184 + L +LE LD+S+N N+ V +L L+ L L +N I S++ + Sbjct: 515 HGRSFTELPQLEALDLSYNSQPFSMQGVGHNLSFVAQLPSLRYLSLAHNGIHSRVSQKLS 574 Query: 185 LHQLQMLELGSNRIRAIEN--------IDTLTNLESLFLGKNKITKLQN--LDALT-NLT 233 L+ L+ N + + L NL L L +N + L LD L +L Sbjct: 575 SASLRALDFSGNSLSQMWAEGDLYLCFFKGLRNLVQLDLSENHLHTLLPRHLDNLPKSLR 634 Query: 234 VLSMQSNRLTKI--EGLQNLVNLRELYLSHNGIEVIEGLENNN--KLTMLDIASNRIKKI 289 L ++ N L L L L L L+ N ++ + +L LD++SN I + Sbjct: 635 QLRLRDNNLAFFNWSSLTVLPRLEALDLAGNQLKALSNGSLPPGIRLQKLDVSSNSIGFV 694 Query: 290 ENISHL--TELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQK 335 + T L E ++ N L++ A +L+ + + NPL Sbjct: 695 IPGFFVRATRLIELNLSANALKTVDPSWFGSLAGTLKILDVSANPLHC 742 Score = 74.4 bits (181), Expect = 7e-14, Method: Composition-based stats. Identities = 72/385 (18%), Positives = 117/385 (30%), Gaps = 111/385 (28%) Query: 77 DAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQN----------------LIKCIEN----- 115 D + NH E L ++ L + N + Sbjct: 202 DTLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCRECPKNFPKLHPDTFSH 261 Query: 116 ---------------------LEELQSLRELDLYDN----QIKKIENLEALTELEILDIS 150 L L+ LDL +N I K LT+L L++S Sbjct: 262 LSRLEGLVLKDSSLYKLEKDWFRGLGRLQVLDLSENFLYDYITKTTIFNDLTQLRRLNLS 321 Query: 151 FN--------LLRNIEGVDKLTRLKKLFLVN---NKISKI--ENLSNLHQLQMLELGSNR 197 FN L L L+KL + ++ I ++L+ L +LQ L L N Sbjct: 322 FNYHKKVSFAHLHLASSFGSLVSLEKLDMHGIFFRSLTNITLQSLTRLPKLQSLHLQLNF 381 Query: 198 I--RAIENIDTLTNLESLFLGKNKIT-------------------------------KLQ 224 I + +L + L N+I+ + Sbjct: 382 INQAQLSIFGAFPSLLFVDLSDNRISGAATPAAALGEVDSRVEVWRLPRGLAPGPLDAVS 441 Query: 225 NLDALTNLT---VLSMQSNRLTKI--EGLQNLVNLRELYLSHNGIEVIEGLENNN---KL 276 + D + + L + N L I E L L+ L LSHN I L Sbjct: 442 SKDFMPSCNLNFTLDLSRNNLVTIQQEMFTRLSRLQCLRLSHNSISQAVNGSQFVPLTSL 501 Query: 277 TMLDIASNRIKKIENIS--HLTELQEFWMNDNLLE-----SWSDLDELKGARSLETVYLE 329 +LD++ N++ S L +L+ ++ N +L + SL + L Sbjct: 502 RVLDLSHNKLDLYHGRSFTELPQLEALDLSYNSQPFSMQGVGHNLSFVAQLPSLRYLSLA 561 Query: 330 RNPLQKDPQYRRKVMLALPSVRQID 354 N + R L+ S+R +D Sbjct: 562 HNGI----HSRVSQKLSSASLRALD 582 Score = 66.7 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 61/310 (19%), Positives = 112/310 (36%), Gaps = 49/310 (15%) Query: 94 FEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIEN--LEALTELEILDISF 151 + +V L + ++ L L N+I + + L+ L +L++ + Sbjct: 16 LQPHGQVDCNWLFLKSVPHFSAGAPRANVTSLSLISNRIHHLHDSDFVHLSNLRVLNLKW 75 Query: 152 N--------------LLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNR 197 N + + L++L L N I+ + L + L S Sbjct: 76 NCPPAGLSPMHFPCRMTIEPNTFLAVPTLEELNLSYNGITTVPALPSSLVSLSLSHTSIL 135 Query: 198 IRAIENIDTLTNLESLFLGKN--KITKLQ--------NLDALTNLTVLSMQSNRLTKIEG 247 + + L L L++ N + L L NLT LS++ N LT++ Sbjct: 136 VLGPTHFTGLHALRFLYMDGNCYYMNPCPRALEVAPGALLGLGNLTHLSLKYNNLTEVPR 195 Query: 248 LQNLVNLRELYLSHNGIEVI--EGLENNNKLTMLDIASNRIK------------------ 287 +L L LS+N I + E L N L +LD+ N + Sbjct: 196 RLPP-SLDTLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCRECPKNFPKL 254 Query: 288 KIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLAL 347 + SHL+ L+ + D+ L + D +G L+ + L N L D + + L Sbjct: 255 HPDTFSHLSRLEGLVLKDSSLYKL-EKDWFRGLGRLQVLDLSENFLY-DYITKTTIFNDL 312 Query: 348 PSVRQIDATF 357 +R+++ +F Sbjct: 313 TQLRRLNLSF 322 Score = 47.8 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 27/119 (22%), Positives = 48/119 (40%), Gaps = 7/119 (5%) Query: 65 LPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIEN--LEELQSL 122 LP ++ + + N+ VL +++ L L N +K + N L L Sbjct: 622 LPRHLDNLPKSLRQLRLRDNNLAFFNWSSLTVLPRLEALDLAGNQLKALSNGSLPPGIRL 681 Query: 123 RELDLYDNQIKKIEN--LEALTELEILDISFNLLRNIEG--VDKLT-RLKKLFLVNNKI 176 ++LD+ N I + T L L++S N L+ ++ L LK L + N + Sbjct: 682 QKLDVSSNSIGFVIPGFFVRATRLIELNLSANALKTVDPSWFGSLAGTLKILDVSANPL 740 >5Y3K-A nrPDB Length = 802 Score = 116 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 74/308 (24%), Positives = 125/308 (40%), Gaps = 36/308 (11%) Query: 79 EDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLE---ELQSLRELDLYDNQIKKI 135 D+ N+ + E F L +++ L L N I N L SL+ LDL N++ Sbjct: 456 LDLSRNNLVTVQPEMFAQLSRLQCLRLSHNSISQAVNGSQFVPLTSLQVLDLSHNKLDLY 515 Query: 136 E--NLEALTELEILDISFNLL--------RNIEGVDKLTRLKKLFLVNNKI-SKIENLSN 184 + L LE LD+S+N N+ V +L L+ L L +N I S++ Sbjct: 516 HGRSFTELPRLEALDLSYNSQPFSMRGVGHNLSFVAQLPTLRYLSLAHNGIHSRVSQQLC 575 Query: 185 LHQLQMLELGSNRIRAIEN--------IDTLTNLESLFLGKNKITKLQNL---DALTNLT 233 L L+ N + + L +L L L +N++ L + +L Sbjct: 576 STSLWALDFSGNSLSQMWAEGDLYLRFFQGLRSLIRLDLSQNRLHTLLPCTLGNLPKSLQ 635 Query: 234 VLSMQSNRLTKI--EGLQNLVNLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKKI 289 +L +++N L L L NL L L+ N ++ + L + +L LD++ N I + Sbjct: 636 LLRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLDVSRNSIIFV 695 Query: 290 EN--ISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQK-----DPQYRRK 342 + T L+E ++ N L + A SLE + + NPL + + Sbjct: 696 VPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEVLDVSANPLHCACGAAFVDFLLQ 755 Query: 343 VMLALPSV 350 V A+P + Sbjct: 756 VQAAVPGL 763 Score = 92.1 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 66/331 (19%), Positives = 121/331 (36%), Gaps = 74/331 (22%) Query: 79 EDVDLNHYRIGKI-----EGFEVLKKVKTLCLRQNLIKC--IENLEELQSLRELDLYDNQ 131 +++D++ + + L ++ L L+ N I + ++ LR +DL DN+ Sbjct: 346 QELDMHGIFFRSLSQKTLQPLARLPMLQRLYLQMNFINQAQLGIFKDFPGLRYIDLSDNR 405 Query: 132 I-------------------------------------KKIENLEALTELEILDISFNLL 154 I + + + L+ LD+S N L Sbjct: 406 ISGAVEPVATTGEVDGGKKVWLTSRDLTPGPLDTPSSEDFMPSCKNLSF--TLDLSRNNL 463 Query: 155 RNIEG--VDKLTRLKKLFLVNNKISKI---ENLSNLHQLQMLELGSNRIRAIEN--IDTL 207 ++ +L+RL+ L L +N IS+ L LQ+L+L N++ L Sbjct: 464 VTVQPEMFAQLSRLQCLRLSHNSISQAVNGSQFVPLTSLQVLDLSHNKLDLYHGRSFTEL 523 Query: 208 TNLESLFLGKN--------KITKLQNLDALTNLTVLSMQSNRL-TKIEGLQNLVNLRELY 258 LE+L L N L + L L LS+ N + +++ +L L Sbjct: 524 PRLEALDLSYNSQPFSMRGVGHNLSFVAQLPTLRYLSLAHNGIHSRVSQQLCSTSLWALD 583 Query: 259 LSHNGIE--------VIEGLENNNKLTMLDIASNRIKKI--ENISHLT-ELQEFWMNDNL 307 S N + + + L LD++ NR+ + + +L LQ + +N Sbjct: 584 FSGNSLSQMWAEGDLYLRFFQGLRSLIRLDLSQNRLHTLLPCTLGNLPKSLQLLRLRNNY 643 Query: 308 LESWSDLDELKGARSLETVYLERNPLQKDPQ 338 L ++ L +LET+ L N L+ Sbjct: 644 LAFFN-WSSLTLLPNLETLDLAGNQLKALSN 673 Score = 91.4 bits (225), Expect = 6e-19, Method: Composition-based stats. Identities = 60/254 (23%), Positives = 99/254 (38%), Gaps = 29/254 (11%) Query: 77 DAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLI--------KCIENLEELQSLRELDLY 128 D+ N + F L +++ L L N + + +L +LR L L Sbjct: 503 QVLDLSHNKLDLYHGRSFTELPRLEALDLSYNSQPFSMRGVGHNLSFVAQLPTLRYLSLA 562 Query: 129 DNQIK-KIENLEALTELEILDISFNLLRN--------IEGVDKLTRLKKLFLVNNKISKI 179 N I ++ T L LD S N L + L L +L L N++ + Sbjct: 563 HNGIHSRVSQQLCSTSLWALDFSGNSLSQMWAEGDLYLRFFQGLRSLIRLDLSQNRLHTL 622 Query: 180 EN--LSNLH-QLQMLELGSNRIR--AIENIDTLTNLESLFLGKNKITKLQ--NLDALTNL 232 L NL LQ+L L +N + ++ L NLE+L L N++ L +L + T L Sbjct: 623 LPCTLGNLPKSLQLLRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQL 682 Query: 233 TVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGIEVIEGL---ENNNKLTMLDIASNRIK 287 L + N + + LREL LS N + +E L +LD+++N + Sbjct: 683 QRLDVSRNSIIFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEVLDVSANPLH 742 Query: 288 KIENISHLTELQEF 301 + + L + Sbjct: 743 CACGAAFVDFLLQV 756 Score = 88.7 bits (218), Expect = 3e-18, Method: Composition-based stats. Identities = 53/249 (21%), Positives = 97/249 (38%), Gaps = 31/249 (12%) Query: 115 NLEELQSLRE-LDLYDNQIKKIEN--LEALTELEILDISFNLLR---NIEGVDKLTRLKK 168 + ++L LDL N + ++ L+ L+ L +S N + N LT L+ Sbjct: 445 FMPSCKNLSFTLDLSRNNLVTVQPEMFAQLSRLQCLRLSHNSISQAVNGSQFVPLTSLQV 504 Query: 169 LFLVNNK--ISKIENLSNLHQLQMLELGSNRI--------RAIENIDTLTNLESLFLGKN 218 L L +NK + + + L +L+ L+L N + + L L L L N Sbjct: 505 LDLSHNKLDLYHGRSFTELPRLEALDLSYNSQPFSMRGVGHNLSFVAQLPTLRYLSLAHN 564 Query: 219 KITKLQNLDAL-TNLTVLSMQSNRLTKIEG--------LQNLVNLRELYLSHNGIEVIEG 269 I + T+L L N L+++ Q L +L L LS N + + Sbjct: 565 GIHSRVSQQLCSTSLWALDFSGNSLSQMWAEGDLYLRFFQGLRSLIRLDLSQNRLHTLLP 624 Query: 270 LE---NNNKLTMLDIASNRIKKI--ENISHLTELQEFWMNDNLLESWSDLDELKGARSLE 324 L +L + +N + +++ L L+ + N L++ S+ L L+ Sbjct: 625 CTLGNLPKSLQLLRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSN-GSLPSGTQLQ 683 Query: 325 TVYLERNPL 333 + + RN + Sbjct: 684 RLDVSRNSI 692 Score = 80.6 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 58/328 (17%), Positives = 121/328 (36%), Gaps = 57/328 (17%) Query: 81 VDLNHYRIGKIEGFEVLKKVKTLCLRQN----------LIKCIENLEELQS--------L 122 + NH E L ++ L + N ++C +L S L Sbjct: 206 LSYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCVECPHKFPQLHSDTFSHLSRL 265 Query: 123 RELDLYDNQIKKIEN--LEALTELEILDISFNLL----RNIEGVDKLTRLKKLFLVNN-- 174 L L D+ + ++ L L +LD+S N L + L +L++L L N Sbjct: 266 EGLVLKDSSLYQLNPRWFRGLGNLTVLDLSENFLYDCITKTKAFQGLAQLRRLNLSFNYH 325 Query: 175 ------KISKIENLSNLHQLQMLELGSN-----RIRAIENIDTLTNLESLFLGKNKIT-- 221 ++ + +L LQ L++ + ++ + L L+ L+L N I Sbjct: 326 KKVSFAHLTLAPSFGSLLSLQELDMHGIFFRSLSQKTLQPLARLPMLQRLYLQMNFINQA 385 Query: 222 KLQNLDALTNLTVLSMQSNRLT-KIEGLQNLVNL---RELYLSHNGIEVIE--------G 269 +L L + + NR++ +E + + ++++L+ + Sbjct: 386 QLGIFKDFPGLRYIDLSDNRISGAVEPVATTGEVDGGKKVWLTSRDLTPGPLDTPSSEDF 445 Query: 270 LENNNKLT-MLDIASNRIKKIEN--ISHLTELQEFWMNDNLLESWSDLDELKGARSLETV 326 + + L+ LD++ N + ++ + L+ LQ ++ N + + + SL+ + Sbjct: 446 MPSCKNLSFTLDLSRNNLVTVQPEMFAQLSRLQCLRLSHNSISQAVNGSQFVPLTSLQVL 505 Query: 327 YLERNPLQKDPQYRRKVMLALPSVRQID 354 L N L Y + LP + +D Sbjct: 506 DLSHNKLDL---YHGRSFTELPRLEALD 530 Score = 77.1 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 66/293 (22%), Positives = 112/293 (38%), Gaps = 47/293 (16%) Query: 99 KVKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRN 156 V +L L N I + + +L +L++L+L N L + ++ Sbjct: 43 NVTSLSLLSNRIHHLHDSDFAQLSNLQKLNLKWN----CPPAG----LSPMHFPCHMTIE 94 Query: 157 IEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIEN--IDTLTNLESLF 214 + L++L L N I+ + L + L L L I ++ + L L L+ Sbjct: 95 PNTFLAVPTLEELNLSYNGITTVPALPS--SLVSLILSRTNILQLDPTSLTGLHALRFLY 152 Query: 215 LGKNKITKLQ----------NLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGI 264 + N K L L NLT LS++ N LT + +L L LS+N I Sbjct: 153 MDGNCYYKNPCGRALEVAPGALLGLGNLTHLSLKYNNLTTVPR-SLPPSLEYLLLSYNHI 211 Query: 265 EVI--EGLENNNKLTMLDIASNRIK-------------KIENI-----SHLTELQEFWMN 304 + E L N L +LD+ N + K + SHL+ L+ + Sbjct: 212 VTLAPEDLANLTALRVLDVGGNCRRCDHARNPCVECPHKFPQLHSDTFSHLSRLEGLVLK 271 Query: 305 DNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDATF 357 D+ L + +G +L + L N L D + K L +R+++ +F Sbjct: 272 DSSLYQLNP-RWFRGLGNLTVLDLSENFLY-DCITKTKAFQGLAQLRRLNLSF 322 Score = 48.6 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 27/119 (22%), Positives = 45/119 (37%), Gaps = 7/119 (5%) Query: 65 LPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIEN--LEELQSL 122 LP + + + N+ +L ++TL L N +K + N L L Sbjct: 623 LPCTLGNLPKSLQLLRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQL 682 Query: 123 RELDLYDNQIKKIEN--LEALTELEILDISFNLLRNIEGV---DKLTRLKKLFLVNNKI 176 + LD+ N I + T L L++S N LR +E L+ L + N + Sbjct: 683 QRLDVSRNSIIFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEVLDVSANPL 741 >5YXM-A nrPDB Length = 203 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 45/165 (27%), Positives = 77/165 (46%), Gaps = 30/165 (18%) Query: 202 ENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVN-LRELYLS 260 + TL + L L N I K+ +L + NL +LS+ N + KIE L + + L EL++S Sbjct: 47 ATLSTLKACKHLALSTNNIEKISSLSGMENLRILSLGRNLIKKIENLDAVADTLEELWIS 106 Query: 261 HNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGA 320 +N I + I L L+ +M++N + +W ++D+L Sbjct: 107 YNQIASLS----------------------GIEKLVNLRVLYMSNNKITNWGEIDKLAAL 144 Query: 321 RSLETVYLERNPLQKD-------PQYRRKVMLALPSVRQIDATFV 358 LE + L NPL D +YR +V+ LP+++++D V Sbjct: 145 DKLEDLLLAGNPLYNDYKENNATSEYRIEVVKRLPNLKKLDGMPV 189 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 58/157 (36%), Positives = 87/157 (55%), Gaps = 21/157 (13%) Query: 77 DAEDVDLNHYRIGKIEGFEV----LKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQI 132 +AE V+L H I IE + LK K L L N I+ I +L +++LR L L N I Sbjct: 29 EAEKVEL-HGMIPPIEKMDATLSTLKACKHLALSTNNIEKISSLSGMENLRILSLGRNLI 87 Query: 133 KKIENLEALTE-LEILDISFNLLRNIEGVDKLTRLKKLFLVNNKIS---KIENLSNLHQL 188 KKIENL+A+ + LE L IS+N + ++ G++KL L+ L++ NNKI+ +I+ L+ L +L Sbjct: 88 KKIENLDAVADTLEELWISYNQIASLSGIEKLVNLRVLYMSNNKITNWGEIDKLAALDKL 147 Query: 189 QMLELGSNRI------------RAIENIDTLTNLESL 213 + L L N + IE + L NL+ L Sbjct: 148 EDLLLAGNPLYNDYKENNATSEYRIEVVKRLPNLKKL 184 >1XCD-A nrPDB Length = 329 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 58/252 (23%), Positives = 110/252 (43%), Gaps = 22/252 (8%) Query: 96 VLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIEN--LEALTELEILDISFNL 153 L+ V+ L L K ++L +L LDL +N+I +I++ + L L L + N Sbjct: 32 HLRVVQCSDLG--LEKVPKDLPPDTAL--LDLQNNKITEIKDGDFKNLKNLHTLILINNK 87 Query: 154 LRNIE--GVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIE--NIDTLTN 209 + I L +L++L+L N++ ++ LQ L + N I + + L Sbjct: 88 ISKISPGAFAPLVKLERLYLSKNQLKELPEKMP-KTLQELRVHENEITKVRKSVFNGLNQ 146 Query: 210 LESLFLGKNKIT----KLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIE 265 + + LG N + + + L+ + + +T I +L EL+L N I Sbjct: 147 MIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPP-SLTELHLDGNKIT 205 Query: 266 VIE--GLENNNKLTMLDIASNRIKKIEN--ISHLTELQEFWMNDNLLESWSDLDELKGAR 321 ++ L+ N L L ++ N I ++N +++ L+E +N+N L L + Sbjct: 206 KVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVP--GGLADHK 263 Query: 322 SLETVYLERNPL 333 ++ VYL N + Sbjct: 264 YIQVVYLHNNNI 275 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 63/278 (22%), Positives = 114/278 (41%), Gaps = 42/278 (15%) Query: 75 DRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQI 132 D D+ N K F+ LK + TL L N I I L L L L NQ+ Sbjct: 53 DTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQL 112 Query: 133 KKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIEN--LSNLHQLQM 190 K++ L++L + N+I+K+ + L+Q+ + Sbjct: 113 KELPE-----------------------KMPKTLQELRVHENEITKVRKSVFNGLNQMIV 149 Query: 191 LELGSNRIR----AIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIE 246 +ELG+N ++ + L + + IT + +LT L + N++TK++ Sbjct: 150 VELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQ-GLPPSLTELHLDGNKITKVD 208 Query: 247 G--LQNLVNLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKKIE-NISHLTELQEF 301 L+ L NL +L LS N I ++ L N L L + +N++ K+ ++ +Q Sbjct: 209 AASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVV 268 Query: 302 WMNDNLLESWSDLDELKGARSLET-----VYLERNPLQ 334 ++++N + + D + + V L NP+Q Sbjct: 269 YLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPVQ 306 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 23/96 (23%), Positives = 43/96 (44%), Gaps = 4/96 (4%) Query: 254 LRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISH--LTELQEFWMNDNLLESW 311 LR + S G+E + + +LD+ +N+I +I++ L L + +N + Sbjct: 33 LRVVQCSDLGLEKVPK-DLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKI 91 Query: 312 SDLDELKGARSLETVYLERNPLQKDPQYRRKVMLAL 347 S LE +YL +N L++ P+ K + L Sbjct: 92 SP-GAFAPLVKLERLYLSKNQLKELPEKMPKTLQEL 126 >6ICZ-o nrPDB Length = 255 Score = 99.5 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 37/131 (28%), Positives = 58/131 (44%), Gaps = 3/131 (2%) Query: 233 TVLSMQSNRLTKIEGL-QNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIEN 291 L ++ ++ IE L L + S N I ++G +L L + +NRI +I Sbjct: 22 RELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGE 81 Query: 292 --ISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPS 349 L L E + +N L DLD L +SL + + RNP+ YR V+ +P Sbjct: 82 GLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQ 141 Query: 350 VRQIDATFVRF 360 VR +D V+ Sbjct: 142 VRVLDFQKVKL 152 Score = 84.8 bits (208), Expect = 5e-17, Method: Composition-based stats. Identities = 39/112 (34%), Positives = 57/112 (50%), Gaps = 3/112 (2%) Query: 105 LRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEA-LTELEILDISFNLLRNIEGVDKL 163 L LI+ RELDL +I IENL A L + + +D S N +R ++G L Sbjct: 4 LTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLL 63 Query: 164 TRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRIRAIENIDTLTNLESL 213 RLK L + NN+I +I L L L L +N + + ++D L +L+SL Sbjct: 64 RRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSL 115 Score = 50.2 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 36/154 (23%), Positives = 70/154 (45%), Gaps = 11/154 (7%) Query: 39 IVADLSEQSLK-DGEERGEEDPEEEHELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVL 97 + A+L EQ+ + R E +++PV + +D + I K++GF +L Sbjct: 4 LTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLL 63 Query: 98 KKVKTLCLRQNLIKCIENL--EELQSLRELDLYDN---QIKKIENLEALTELEILDISFN 152 +++KTL + N I I + L L EL L +N ++ ++ L +L L L I N Sbjct: 64 RRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRN 123 Query: 153 LLRN-----IEGVDKLTRLKKLFLVNNKISKIEN 181 + N + + K+ +++ L K+ + + Sbjct: 124 PVTNKKHYRLYVIYKVPQVRVLDFQKVKLKERQE 157 >2XOT-A nrPDB Length = 361 Score = 98.3 bits (243), Expect = 5e-21, Method: Composition-based stats. Identities = 49/210 (23%), Positives = 89/210 (42%), Gaps = 39/210 (18%) Query: 125 LDLYDNQIKKIE-NLEALTELEILDISFNLLRNIEG---VDKLTRLKKLFLVNNKISKI- 179 L Q+ + +L + T L LD+S N L + +LT L L L +N ++ I Sbjct: 23 LSCSKQQLPNVPQSLPSYTAL--LDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHLNFIS 80 Query: 180 -ENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQ 238 E + L+ L+L SN + ++ L L VL + Sbjct: 81 SEAFVPVPNLRYLDLSSNHLHTLDEF--------------------LFSDLQALEVLLLY 120 Query: 239 SNRLTKIE--GLQNLVNLRELYLSHNGIEVIE-----GLENNNKLTMLDIASNRIKKIE- 290 +N + ++ +++ L++LYLS N I KL +LD++SN++KK+ Sbjct: 121 NNHIVVVDRNAFEDMAQLQKLYLSQNQISRFPVELIKDGNKLPKLMLLDLSSNKLKKLPL 180 Query: 291 -NISHLTELQE--FWMNDNLLESWSDLDEL 317 ++ L + ++++N LE L +L Sbjct: 181 TDLQKLPAWVKNGLYLHNNPLECDCKLYQL 210 Score = 64.8 bits (156), Expect = 6e-11, Method: Composition-based stats. Identities = 30/152 (19%), Positives = 63/152 (41%), Gaps = 31/152 (20%) Query: 81 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEA 140 + NH E F + ++ L L N + ++ Sbjct: 71 LSHNHLNFISSEAFVPVPNLRYLDLSSNHLHTLDEFL--------------------FSD 110 Query: 141 LTELEILDISFNLLRNIE--GVDKLTRLKKLFLVNNKISK-----IENLSNLHQLQMLEL 193 L LE+L + N + ++ + + +L+KL+L N+IS+ I++ + L +L +L+L Sbjct: 111 LQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNQISRFPVELIKDGNKLPKLMLLDL 170 Query: 194 GSNRIRAIE--NIDTLTNLES--LFLGKNKIT 221 SN+++ + ++ L L+L N + Sbjct: 171 SSNKLKKLPLTDLQKLPAWVKNGLYLHNNPLE 202 Score = 62.9 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 34/144 (23%), Positives = 59/144 (40%), Gaps = 13/144 (9%) Query: 218 NKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELY---LSHNGIEVI--EGLEN 272 N L + AL L + N L+++ L L+ LSHN + I E Sbjct: 32 NVPQSLPSYTAL-----LDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHLNFISSEAFVP 86 Query: 273 NNKLTMLDIASNRIKKIENI--SHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLER 330 L LD++SN + ++ S L L+ + +N + D + + L+ +YL + Sbjct: 87 VPNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVV-DRNAFEDMAQLQKLYLSQ 145 Query: 331 NPLQKDPQYRRKVMLALPSVRQID 354 N + + P K LP + +D Sbjct: 146 NQISRFPVELIKDGNKLPKLMLLD 169 Score = 44.8 bits (104), Expect = 6e-05, Method: Composition-based stats. Identities = 30/128 (23%), Positives = 50/128 (39%), Gaps = 23/128 (17%) Query: 79 EDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCI--ENLEELQSLRELDLYDNQIKKIE 136 D+ NH F L+ ++ L L N I + E++ L++L L NQI + Sbjct: 93 LDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNQISRFP 152 Query: 137 NLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE--NLSNLHQLQM--LE 192 + I+ +KL +L L L +NK+ K+ +L L L Sbjct: 153 -----------------VELIKDGNKLPKLMLLDLSSNKLKKLPLTDLQKLPAWVKNGLY 195 Query: 193 LGSNRIRA 200 L +N + Sbjct: 196 LHNNPLEC 203 >5YQ5-A nrPDB Length = 430 Score = 97.9 bits (242), Expect = 6e-21, Method: Composition-based stats. Identities = 60/250 (24%), Positives = 108/250 (43%), Gaps = 24/250 (9%) Query: 101 KTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKI--ENLEALTELEILDISFNLLRN-- 156 ++ +K I N+ +++L L N+I+ + + T L+ +++S N +++ Sbjct: 72 SSMYCDNRKLKTIPNIP--MHIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQK 129 Query: 157 --IEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAI--ENIDTLTNLES 212 KL L +L L +N + + L+ L LG N I + +D L NL Sbjct: 130 IDYGVFAKLPNLLQLHLEHNNLEEF-PFPLPKSLERLLLGYNEISKLQTNAMDGLVNLTM 188 Query: 213 LFLGKNKITKL----QNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIE 268 L L N + + + L L++ SNRL + +L L L +N I I Sbjct: 189 LDLCYNYLHDSLLKDKIFAKMEKLMQLNLCSNRLESMPP-GLPSSLMYLSLENNSISSIP 247 Query: 269 G--LENNNKLTMLDIASNRIKKIE-NISHLTELQEFWMNDNLLESWSDLDELKGARSLET 325 + KL L ++ N+++ I NI +L + E + N L+ R+LE Sbjct: 248 EKYFDKLPKLHTLRMSHNKLQDIPYNIFNLPNIVELSVGHNKLKQ-----AFYIPRNLEH 302 Query: 326 VYLERNPLQK 335 +YL+ N ++K Sbjct: 303 LYLQNNEIEK 312 Score = 93.7 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 59/261 (22%), Positives = 105/261 (40%), Gaps = 31/261 (11%) Query: 80 DVDLNHYRIGKIE----GFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKI 135 +++L+H +I + F L + L L N ++ +SL L L N+I K+ Sbjct: 117 EINLSHNKIKSQKIDYGVFAKLPNLLQLHLEHNNLEEF-PFPLPKSLERLLLGYNEISKL 175 Query: 136 E--NLEALTELEILDISFNLLRNI----EGVDKLTRLKKLFLVNNKISKIENLSNLHQLQ 189 + ++ L L +LD+ +N L + + K+ +L +L L +N++ + L Sbjct: 176 QTNAMDGLVNLTMLDLCYNYLHDSLLKDKIFAKMEKLMQLNLCSNRLESMPPGLP-SSLM 234 Query: 190 MLELGSNRIRAIEN--IDTLTNLESLFLGKNKITKLQ-NLDALTNLTVLSMQSNRLTKIE 246 L L +N I +I D L L +L + NK+ + N+ L N+ LS+ N+L + Sbjct: 235 YLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIPYNIFNLPNIVELSVGHNKLKQ-- 292 Query: 247 GLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDN 306 NL LYL +N IE + + L L ++ N Sbjct: 293 AFYIPRNLEHLYLQNNEIEKMNLTVMCPSIDPLHYHH--------------LTYIRVDQN 338 Query: 307 LLESWSDLDELKGARSLETVY 327 L+ + T+Y Sbjct: 339 KLKEPISSYIFFCFPHIHTIY 359 Score = 76.0 bits (185), Expect = 2e-14, Method: Composition-based stats. Identities = 47/196 (23%), Positives = 79/196 (40%), Gaps = 19/196 (9%) Query: 168 KLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIEN--IDTLTNLESLFLGKNKIT---- 221 ++ N K+ I N+ +Q L L N I A+ T+L+ + L NKI Sbjct: 73 SMYCDNRKLKTIPNIP--MHIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKI 130 Query: 222 KLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEG--LENNNKLTML 279 L NL L ++ N L + +L L L +N I ++ ++ LTML Sbjct: 131 DYGVFAKLPNLLQLHLEHNNLEEFP-FPLPKSLERLLLGYNEISKLQTNAMDGLVNLTML 189 Query: 280 DIASN----RIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQK 335 D+ N + K + + + +L + + N LES SL + LE N + Sbjct: 190 DLCYNYLHDSLLKDKIFAKMEKLMQLNLCSNRLESMPPGLP----SSLMYLSLENNSISS 245 Query: 336 DPQYRRKVMLALPSVR 351 P+ + L ++R Sbjct: 246 IPEKYFDKLPKLHTLR 261 >4QDH-A nrPDB Length = 438 Score = 97.9 bits (242), Expect = 6e-21, Method: Composition-based stats. Identities = 68/314 (21%), Positives = 122/314 (38%), Gaps = 57/314 (18%) Query: 79 EDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLE---ELQSLRELDLYDNQIKKI 135 + N+ K E F L +++ L L N I N L +L+ LDL N++ Sbjct: 64 LSLSRNNLVTIKPEMFVNLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLY 123 Query: 136 E--NLEALTELEILDISFNLL--------RNIEGVDKLTRLKKLFLVNNKI-SKIENLSN 184 + L +L+ LD+S+N N V L+ L+ L L +N I +++ + N Sbjct: 124 HWKSFSELPQLQALDLSYNSQPFSMKGIGHNFSFVTHLSMLQSLSLAHNDIHTRVSSHLN 183 Query: 185 LHQLQMLELGSNRIRAIEN--------IDTLTNLESLFLGKNKITKLQN----------- 225 + ++ L+ N + + + L+ L L L +N + L+ Sbjct: 184 SNSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQNLDNLPKSLK 243 Query: 226 ----------------LDALTNLTVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGIEVI 267 L L NL VL + N+L + L N L++L +S N I + Sbjct: 244 LLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTNGTLPNGTLLQKLDVSSNSIVSV 303 Query: 268 EG--LENNNKLTMLDIASNRIKKIENISHLT---ELQEFWMNDNLLESWSDLDELKGARS 322 +L ++++ N +K ++ L+E ++ N L+S D S Sbjct: 304 VPAFFALAVELKEVNLSHNILKTVDRSWFGPIVMNLKELALDTNQLKSVPD-GIFDRLTS 362 Query: 323 LETVYLERNPLQKD 336 L+ ++L NP Sbjct: 363 LQKIWLHTNPWDCS 376 Score = 74.4 bits (181), Expect = 6e-14, Method: Composition-based stats. Identities = 55/238 (23%), Positives = 104/238 (43%), Gaps = 28/238 (11%) Query: 125 LDLYDNQIKKIEN--LEALTELEILDISFNLLRNIEG--VDKLTRLKKLFLVNNKISKI- 179 L+L N+++ + + + LT+L L +S N L I+ L+RL+ L L +N I++ Sbjct: 40 LELESNKLQSLPHGVFDKLTQLTKLSLSRNNLVTIKPEMFVNLSRLQCLSLSHNSIAQAV 99 Query: 180 --ENLSNLHQLQMLELGSNRIR--AIENIDTLTNLESLFLGKN--------KITKLQNLD 227 L LQ+L+L N++ ++ L L++L L N + Sbjct: 100 NGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYNSQPFSMKGIGHNFSFVT 159 Query: 228 ALTNLTVLSMQSNRL-TKIEGLQNLVNLRELYLSHNGIE--------VIEGLENNNKLTM 278 L+ L LS+ N + T++ N ++R L S NG+ + + + L Sbjct: 160 HLSMLQSLSLAHNDIHTRVSSHLNSNSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLK 219 Query: 279 LDIASN--RIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQ 334 LD++ N I + +N+ +L + + + S+ + L +LE + L N L+ Sbjct: 220 LDLSQNNLHILRPQNLDNLPKSLKLLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLK 277 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 28/111 (25%), Positives = 48/111 (43%), Gaps = 8/111 (7%) Query: 229 LTNLTVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGIEVIEG--LENNNKLTMLDIASN 284 ++ T L ++SN+L + L L +L LS N + I+ N ++L L ++ N Sbjct: 34 PSSATRLELESNKLQSLPHGVFDKLTQLTKLSLSRNNLVTIKPEMFVNLSRLQCLSLSHN 93 Query: 285 RIKKIENISH---LTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNP 332 I + N S LT LQ ++ N L+ + L+ + L N Sbjct: 94 SIAQAVNGSQFLPLTNLQVLDLSHNKLDLY-HWKSFSELPQLQALDLSYNS 143 >3G06-A nrPDB Length = 622 Score = 97.5 bits (241), Expect = 7e-21, Method: Composition-based stats. Identities = 47/240 (19%), Positives = 101/240 (42%), Gaps = 22/240 (9%) Query: 101 KTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGV 160 L + ++ + + + + L + DN + + L EL L++S N L ++ + Sbjct: 43 AVLNVGESGLTTLPDCLP-AHITTLVIPDNNLTSLPALPP--ELRTLEVSGNQLTSLPVL 99 Query: 161 DKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKI 220 L +L + +N ++ + L + + N++ ++ + L+ L + N++ Sbjct: 100 --PPGLLELSIFSNPLTHLPALPSGLCKLWIF--GNQLTSLPVL--PPGLQELSVSDNQL 153 Query: 221 TKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLD 280 L L + L L +N+LT + L + L+EL +S N + + L ++L L Sbjct: 154 ASLPALPS--ELCKLWAYNNQLTSLPMLPS--GLQELSVSDNQLASLPTL--PSELYKLW 207 Query: 281 IASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYR 340 +NR+ + + + L+E ++ N L S L L+ + + N L P Sbjct: 208 AYNNRLTSLPALP--SGLKELIVSGNRLTSLPVLPS-----ELKELMVSGNRLTSLPMLP 260 >1DCE-A nrPDB Length = 567 Score = 96.8 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 37/111 (33%), Positives = 60/111 (54%), Gaps = 4/111 (3%) Query: 99 KVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIEN-LEALTELEILDISFNLLRNI 157 V+ L L + + +LE+L + LDL N+++ + L AL LE+L S N L N+ Sbjct: 442 DVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNALENV 501 Query: 158 EGVDKLTRLKKLFLVNNKI---SKIENLSNLHQLQMLELGSNRIRAIENID 205 +GV L RL++L L NN++ + I+ L + +L +L L N + E I Sbjct: 502 DGVANLPRLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGNSLCQEEGIQ 552 Score = 72.5 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 39/148 (26%), Positives = 73/148 (49%), Gaps = 5/148 (3%) Query: 207 LTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEV 266 L +L S FL +N + K++ D + VL + LT + L+ L+ + L LSHN + Sbjct: 422 LDDLRSKFLLENSVLKMEYAD----VRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRA 477 Query: 267 IEG-LENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLET 325 + L L +L + N ++ ++ +++L LQE + +N L+ + + L L Sbjct: 478 LPPALAALRCLEVLQASDNALENVDGVANLPRLQELLLCNNRLQQSAAIQPLVSCPRLVL 537 Query: 326 VYLERNPLQKDPQYRRKVMLALPSVRQI 353 + L+ N L ++ + ++ LPSV I Sbjct: 538 LNLQGNSLCQEEGIQERLAEMLPSVSSI 565 Score = 61.3 bits (147), Expect = 7e-10, Method: Composition-based stats. Identities = 33/135 (24%), Positives = 69/135 (51%), Gaps = 8/135 (5%) Query: 119 LQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISK 178 L LR L +N + K+E ++ +L ++ L + +++L + L L +N++ Sbjct: 422 LDDLRSKFLLENSVLKME----YADVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRA 477 Query: 179 IEN-LSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITK---LQNLDALTNLTV 234 + L+ L L++L+ N + ++ + L L+ L L N++ + +Q L + L + Sbjct: 478 LPPALAALRCLEVLQASDNALENVDGVANLPRLQELLLCNNRLQQSAAIQPLVSCPRLVL 537 Query: 235 LSMQSNRLTKIEGLQ 249 L++Q N L + EG+Q Sbjct: 538 LNLQGNSLCQEEGIQ 552 >5KH1-A nrPDB Length = 591 Score = 90.2 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 51/230 (22%), Positives = 101/230 (43%), Gaps = 17/230 (7%) Query: 60 EEEHELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEEL 119 EE+ ++ L ++DL+ + + E+ +K++ + +N + I L Sbjct: 51 EEQRDIAFQRLVSCLQNQETNLDLSELGLTTL--PEIPPGIKSINISKNNLSLISPLPA- 107 Query: 120 QSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI 179 SL +L++ N++ ++ L L++L+ S N L + + LK+L + NN++ + Sbjct: 108 -SLTQLNVSYNRLIELPALP--QGLKLLNASHNQLITLPTLPI--SLKELHVSNNQLCSL 162 Query: 180 ENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQS 239 L L L+ L++ N + + + +L+ + N +++L L N+ + Sbjct: 163 PVLPEL--LETLDVSCNGLAVLPPL--PFSLQEISAIGNLLSELPPLPH--NIHSIWAID 216 Query: 240 NRLTKIEGLQNLVNLRELYLSHNGIEVIE-GLENNNKLTMLDIASNRIKK 288 N LT I L NLR Y N I I + N +DI+ N + Sbjct: 217 NMLTDIPYL--PENLRNGYFDINQISHIPESILNLRNECSIDISDNPLSS 264 >3WPI-A nrPDB Length = 803 Score = 89.8 bits (221), Expect = 1e-18, Method: Composition-based stats. Identities = 74/318 (23%), Positives = 127/318 (39%), Gaps = 36/318 (11%) Query: 69 METINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLE---ELQSLREL 125 M+ + D+ N+ K E F L +++ L L N I N L +L+ L Sbjct: 447 MDRCKNFKFTMDLSRNNLVTIKPEMFVQLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVL 506 Query: 126 DLYDNQIKKIE--NLEALTELEILDISFNLL--------RNIEGVDKLTRLKKLFLVNNK 175 DL N++ + L +L+ LD+S+N V L+ L+ L L +N Sbjct: 507 DLSHNKLDLYHWKSFSELPQLQALDLSYNSQPFSMKGIGHQFSFVTHLSMLQSLSLAHND 566 Query: 176 I-SKIENLSNLHQLQMLELGSNRIRAIEN--------IDTLTNLESLFLGKNKITKL--Q 224 I +++ + N + ++ L+ N + + + L+ L L L +N + L Q Sbjct: 567 IHTRVSSHLNSNSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQ 626 Query: 225 NLDALTNLTVLSMQS-NRLTKI--EGLQNLVNLRELYLSHNGIEVIE--GLENNNKLTML 279 NLD L L N L+ L L NL L L+ N ++ + L N L L Sbjct: 627 NLDNLPKSLKLLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTQGTLPNGTLLQKL 686 Query: 280 DIASNRIKKIEN--ISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQK-- 335 D++SN I + + EL+E ++ N+L++ L + + NPL Sbjct: 687 DVSSNSIVSVVPAFFALAVELKEVNLSHNILKTVDRSWFGPIVMQLTVLDVRSNPLHCAC 746 Query: 336 ---DPQYRRKVMLALPSV 350 +V +P + Sbjct: 747 GAAFVDLLLEVQTKVPGL 764 Score = 73.7 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 52/279 (18%), Positives = 104/279 (37%), Gaps = 48/279 (17%) Query: 79 EDVDLNHYR--IGKIEGFEVLKKVKTLCLRQN--------LIKCIENLEELQSLRELD-- 126 D+ N I F+ L +++ L L N + + + L SL+EL+ Sbjct: 292 LDLSENFLYESITHTNAFQNLTRLRKLNLSFNYRKKVSFARLHLASSFKNLVSLQELNMN 351 Query: 127 ------LYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE 180 L ++ + +L L L L ++F + L+ + L +N+IS Sbjct: 352 GIFFRLLNKYTLRWLADLPKLHTLH-LQMNFINQAQLSIFGTFRALRFVDLSDNRISGPS 410 Query: 181 NLSNLHQLQMLELGSNRIRAIEN-------------IDTLTNLE-SLFLGKNKITKLQN- 225 LS + + + + + +D N + ++ L +N + ++ Sbjct: 411 TLSEATPEEADDAEQEELLSADPHPAPLSTPASKNFMDRCKNFKFTMDLSRNNLVTIKPE 470 Query: 226 -LDALTNLTVLSMQSNRLTKI---EGLQNLVNLRELYLSHNGIEVIEG--LENNNKLTML 279 L+ L LS+ N + + L NL+ L LSHN +++ +L L Sbjct: 471 MFVQLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELPQLQAL 530 Query: 280 DIASNRI--------KKIENISHLTELQEFWMNDNLLES 310 D++ N + ++HL+ LQ + N + + Sbjct: 531 DLSYNSQPFSMKGIGHQFSFVTHLSMLQSLSLAHNDIHT 569 Score = 71.0 bits (172), Expect = 9e-13, Method: Composition-based stats. Identities = 71/314 (22%), Positives = 117/314 (37%), Gaps = 50/314 (15%) Query: 81 VDLNHYRIGKIEGFE---VLKKVKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQIKKI 135 VD N + + F + L L N I + N L +LR+L+L N Sbjct: 22 VDCNWLFLKSVPRFSAAASCSNITRLSLISNRIHHLHNSDFVHLSNLRQLNLKWNCPP-- 79 Query: 136 ENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGS 195 T L L S ++ + L++L L N I+ + L + L L L Sbjct: 80 ------TGLSPLHFSCHMTIEPRTFLAMRTLEELNLSYNGITTVPRLPS--SLVNLSLSH 131 Query: 196 NRIRAIEN--IDTLTNLESLFLGKNKITKLQ----------NLDALTNLTVLSMQSNRLT 243 I ++ + L +L LF+ N K L L+ LT LS++ N LT Sbjct: 132 TNILVLDANSLAGLYSLRVLFMDGNCYYKNPCTGAVKVTPGALLGLSQLTHLSLKYNNLT 191 Query: 244 KIEGLQNLVNLRELYLSHNGIEVI--EGLENNNKLTMLDIASNRIK-------------- 287 K+ Q +L L +S+N I + E L L +LD+ N + Sbjct: 192 KVPR-QLPPSLEYLLVSYNLIVKLGPEDLAQLTSLRVLDVGGNCRRCDHAPNPCIECGQK 250 Query: 288 ----KIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKV 343 E HL+ L+ + D+ L + + +G L + L N L + + Sbjct: 251 SLHLHPETFHHLSHLEGLVLKDSSLHTLNS-SWFQGLVQLSVLDLSENFLYESITHT-NA 308 Query: 344 MLALPSVRQIDATF 357 L +R+++ +F Sbjct: 309 FQNLTRLRKLNLSF 322 >3CIG-A nrPDB Length = 697 Score = 87.9 bits (216), Expect = 5e-18, Method: Composition-based stats. Identities = 70/315 (22%), Positives = 112/315 (35%), Gaps = 45/315 (14%) Query: 79 EDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIEN--LEELQSLRELDL--------- 127 D+ N+ F L ++ L L N I+ + L +LR L L Sbjct: 253 LDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSLKRAFTKQSV 312 Query: 128 ---YDNQIKKIENLEALTELEILDISFNLL--RNIEGVDKLTRLKKLFLVNNKISKIENL 182 I + + L LE L++ N + L LK L L + ++ L Sbjct: 313 SLASHPNIDDF-SFQWLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSLSK-TFTSLQTL 370 Query: 183 SNLHQ-------LQMLELGSNRIRAIEN--IDTLTNLESLFLGKNKIT---KLQNLDALT 230 +N L L L N I I N L L L LG N+I Q L Sbjct: 371 TNETFVSLAHSPLLTLNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKLSGQEWRGLR 430 Query: 231 NLTVLSMQSNRLTKI--EGLQNLVNLRELYLSHNGIEVIE----GLENNNKLTMLDIASN 284 N+ + + N+ ++ + +L+ L L ++ ++ LT+LD+++N Sbjct: 431 NIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNN 490 Query: 285 RIKKIEN--ISHLTELQEFWMNDNLLE-------SWSDLDELKGARSLETVYLERNPLQK 335 I I + L L+ N L ++ LKG L + LE N L + Sbjct: 491 NIANINEDLLEGLENLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLESNGLDE 550 Query: 336 DPQYRRKVMLALPSV 350 P K + L S+ Sbjct: 551 IPVGVFKNLFELKSI 565 Score = 80.2 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 59/287 (20%), Positives = 105/287 (36%), Gaps = 50/287 (17%) Query: 108 NLIKCIENLEELQSLRELDLYDNQIKKIE--NLEALTELEILDISFNLLRNIEG--VDKL 163 L ++L ++ L+L NQ++++ N ++L ILD FN + +E L Sbjct: 15 KLTHIPDDLPS--NITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLEPELCQIL 72 Query: 164 TRLKKLFLVNNKISKI--ENLSNLHQLQMLELGSNRIRAI--ENIDTLTNLESLFLGKNK 219 LK L L +N++S+I + L L+L SN I I NL L L N Sbjct: 73 PLLKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNG 132 Query: 220 ITKLQ----------------------------NLDALTNLTVLSMQSNRLTKIE--GLQ 249 ++ + ++L L + SN L + Q Sbjct: 133 LSSTKLGTGVQLENLQELLLAKNKILALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCFQ 192 Query: 250 NLVNLRELYLSHNGI-----EVIEGLENNNKLTMLDIASNRIKKIENIS----HLTELQE 300 + L L L++ + E + +N + L +A+N++ + T L + Sbjct: 193 TIGKLFALLLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSESTFSGLKWTNLTQ 252 Query: 301 FWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLAL 347 ++ N L + SL + LE N +Q+ + L Sbjct: 253 LDLSYNNLHDVGN-GSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNL 298 Score = 77.5 bits (189), Expect = 7e-15, Method: Composition-based stats. Identities = 69/308 (22%), Positives = 124/308 (40%), Gaps = 36/308 (11%) Query: 79 EDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEEL--QSLRELDLYDNQIKKIE 136 D N + E ++L +K L L+ N + I + + +L ELDL N I KI+ Sbjct: 54 LDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHKIK 113 Query: 137 --NLEALTELEILDISFNLLRN--IEGVDKLTRLKKLFLVNNKISKIE----NLSNLHQL 188 + L LD+S N L + + +L L++L L NKI + L Sbjct: 114 SNPFKNQKNLIKLDLSHNGLSSTKLGTGVQLENLQELLLAKNKILALRSEELEFLGNSSL 173 Query: 189 QMLELGSNRIRAIEN--IDTLTNLESLFLGKNKITKLQNLDAL-----TNLTVLSMQSNR 241 + L+L SN ++ T+ L +L L ++ T++ LS+ +N+ Sbjct: 174 RKLDLSSNPLKEFSPGCFQTIGKLFALLLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQ 233 Query: 242 L--TKIEGLQNL--VNLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKKIENISH- 294 L T L NL +L LS+N + + L L + N I+++ S Sbjct: 234 LLATSESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFY 293 Query: 295 -LTELQEFWM------NDNLLESWSDLDE--LKGARSLETVYLERNPLQKDPQYRRKVML 345 L+ L+ + L S ++D+ + + LE + ++ N + P + Sbjct: 294 GLSNLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNI---PSTKSNTFT 350 Query: 346 ALPSVRQI 353 L S++ + Sbjct: 351 GLVSLKYL 358 Score = 74.0 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 53/241 (21%), Positives = 93/241 (38%), Gaps = 31/241 (12%) Query: 79 EDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLR-----------ELDL 127 ++ NH F L +++ L L N I+ + +E + LR L L Sbjct: 386 LNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKYLQL 445 Query: 128 YDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIEN--LSNL 185 + + +L+ L L + + + + L L L L NN I+ I L L Sbjct: 446 STSSFALVPSLQRLM-LRRVALKNVDI-SPSPFRPLRNLTILDLSNNNIANINEDLLEGL 503 Query: 186 HQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKI 245 L++L+ N NL L+ N + L L++L +L+++SN L +I Sbjct: 504 ENLEILDFQHN------------NLARLWKRANPGGPVNFLKGLSHLHILNLESNGLDEI 551 Query: 246 E--GLQNLVNLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKKIENISHLTELQEF 301 +NL L+ + L N + +E ++ L L++ N I +E Q Sbjct: 552 PVGVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLITSVEKDVFGPPFQNL 611 Query: 302 W 302 Sbjct: 612 N 612 Score = 73.3 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 59/318 (18%), Positives = 110/318 (34%), Gaps = 65/318 (20%) Query: 79 EDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQIKKIE 136 + V L + F+ LK ++ L + N I ++ L SL+ L L K Sbjct: 310 QSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSLS----KTFT 365 Query: 137 NLEALTELEILDISFNLLRNI------------EGVDKLTRLKKLFLVNNKIS---KIEN 181 +L+ LT + ++ + L + L +L+ L L N+I + Sbjct: 366 SLQTLTNETFVSLAHSPLLTLNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKLSGQE 425 Query: 182 LSNLHQLQMLELGSNRIRAIEN--IDTLTNLESLFLGK----NKITKLQNLDALTNLTVL 235 L + + L N+ + + +L+ L L + N L NLT+L Sbjct: 426 WRGLRNIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTIL 485 Query: 236 SMQSNRLTKI--EGLQNLVNLRELYLSHNGIE----------VIEGLENNNKLTMLDIAS 283 + +N + I + L+ L NL L HN + + L+ + L +L++ S Sbjct: 486 DLSNNNIANINEDLLEGLENLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLES 545 Query: 284 NRIKKIEN--------------------------ISHLTELQEFWMNDNLLESWSDLDEL 317 N + +I T L+ + NL+ S Sbjct: 546 NGLDEIPVGVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLITSVEKDVFG 605 Query: 318 KGARSLETVYLERNPLQK 335 ++L ++ + NP Sbjct: 606 PPFQNLNSLDMRFNPFDC 623 Score = 65.2 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 57/219 (26%), Positives = 99/219 (45%), Gaps = 18/219 (8%) Query: 145 EILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRIRAIE 202 + D S L +I D + + L L +N++ ++ + QL +L+ G N I +E Sbjct: 7 NVADCSHLKLTHIPD-DLPSNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLE 65 Query: 203 N--IDTLTNLESLFLGKNKITKL--QNLDALTNLTVLSMQSNRLTKIE--GLQNLVNLRE 256 L L+ L L N+++++ Q TNLT L + SN + KI+ +N NL + Sbjct: 66 PELCQILPLLKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQKNLIK 125 Query: 257 LYLSHNGIEV--IEGLENNNKLTMLDIASNRIKKI--ENISHL--TELQEFWMNDNLLES 310 L LSHNG+ + L L +A N+I + E + L + L++ ++ N L+ Sbjct: 126 LDLSHNGLSSTKLGTGVQLENLQELLLAKNKILALRSEELEFLGNSSLRKLDLSSNPLKE 185 Query: 311 WSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPS 349 +S + L + L N Q +P K+ L + Sbjct: 186 FSP-GCFQTIGKLFALLL--NNAQLNPHLTEKLCWELSN 221 >5XJX-C nrPDB Length = 433 Score = 87.9 bits (216), Expect = 6e-18, Method: Composition-based stats. Identities = 60/260 (23%), Positives = 103/260 (39%), Gaps = 20/260 (7%) Query: 114 ENLEELQSLRELDLYDNQIKKIENLEAL-----TELEILDISFNLL--RNIEGVDKLTRL 166 E+L L+ L+ L Y + + + A + L+ L + N + + LT L Sbjct: 99 ESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNL 158 Query: 167 KKLFLVNNKIS-KIE-NLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKIT-KL 223 K L L N ++ I + + L+ L+L NR+ L L L L +N +T + Sbjct: 159 KVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPV 218 Query: 224 QN-LDALTNLTVLSMQSNRLT--KIEGLQNLVNLRELYLSHNGIE--VIEGLENNNKLTM 278 L + +L + + NR+T E + L L L LS+N + L+ N L Sbjct: 219 PPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQA 278 Query: 279 LDIASNR--IKKIENISH--LTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQ 334 L + N I + L L +++ ++ S L SL ++LE N L Sbjct: 279 LMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQ-GSIPKSLTRLNSLRVLHLEGNNLT 337 Query: 335 KDPQYRRKVMLALPSVRQID 354 + + + L +R D Sbjct: 338 GEIPLEFRDVKHLSELRLND 357 Score = 81.0 bits (198), Expect = 7e-16, Method: Composition-based stats. Identities = 53/214 (24%), Positives = 89/214 (41%), Gaps = 15/214 (7%) Query: 65 LPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRE 124 +P ++ + + D+ NH F +++L L N + L +L Sbjct: 148 IPDELGNLTNLK-VLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSV 206 Query: 125 LDLYDNQI--KKIENLEALTELEILDISFNLLR--NIEGVDKLTRLKKLFLVNNKIS--K 178 LDL N + L + L +D+S N + E +++L +L L L N++S Sbjct: 207 LDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPF 266 Query: 179 IENLSNLHQLQMLELGSN----RIRAIENIDTLTNLESLFLGK-NKITKLQ-NLDALTNL 232 +L L+ LQ L L N L NL L L N + +L L +L Sbjct: 267 PSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSL 326 Query: 233 TVLSMQSNRLT-KIE-GLQNLVNLRELYLSHNGI 264 VL ++ N LT +I +++ +L EL L+ N + Sbjct: 327 RVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSL 360 Score = 64.8 bits (156), Expect = 6e-11, Method: Composition-based stats. Identities = 50/215 (23%), Positives = 83/215 (38%), Gaps = 42/215 (19%) Query: 65 LPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIK--CIENLEELQSL 122 +P+ + R + D+ N G I GF VL + L L QNL+ L SL Sbjct: 172 IPLSFNRFSGLR-SLDLSGNRLT-GSIPGF-VLPALSVLDLNQNLLTGPVPPTLTSCGSL 228 Query: 123 RELDLYDNQI--KKIENLEALTELEILDISFNLLR-----NIEGVDKLT----------- 164 ++DL N++ E++ L +L +LD+S+N L +++G++ L Sbjct: 229 IKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFS 288 Query: 165 ------------RLKKLFLVNNKIS-KIEN-LSNLHQLQMLELGSNRIRAIEN--IDTLT 208 L L L N I I L+ L+ L++L L N + + Sbjct: 289 TTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVK 348 Query: 209 NLESLFLGKNKITKLQNLDA---LTNLTVLSMQSN 240 +L L L N +T + L + +N Sbjct: 349 HLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNN 383 >3ULU-A nrPDB Length = 694 Score = 87.9 bits (216), Expect = 7e-18, Method: Composition-based stats. Identities = 75/297 (25%), Positives = 121/297 (40%), Gaps = 48/297 (16%) Query: 68 DMETINLDRDAEDVDLNHYRIGKIEGF--EVLKKVKTLCLRQNLIKCIEN--LEELQSLR 123 ++ +NL R ++ + KI+ F + LK ++ L + N I I++ L +L+ Sbjct: 307 NVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLK 366 Query: 124 ELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIEN-- 181 L L + +L LT + ++ + L L L NKISKIE+ Sbjct: 367 YLSLSN----SFTSLRTLTNETFVSLAHSP------------LHILNLTKNKISKIESDA 410 Query: 182 LSNLHQLQMLELGSNRIRAI---ENIDTLTNLESLFLGKNKITKL--QNLDALTNLTVLS 236 S L L++L+LG N I + L N+ ++L NK +L + + +L L Sbjct: 411 FSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLM 470 Query: 237 MQSNRLTKI----EGLQNLVNLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKKIE 290 ++ L + Q L NL L LS+N I I LE KL +LD+ N + + Sbjct: 471 LRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLAR-- 528 Query: 291 NISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLAL 347 W + N + LKG L + LE N + P K + L Sbjct: 529 ----------LWKHAN---PGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFEL 572 Score = 80.2 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 67/309 (21%), Positives = 126/309 (40%), Gaps = 36/309 (11%) Query: 78 AEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQIKKI 135 + DV N + E + L +K L L+ N + + + +L EL L N I+KI Sbjct: 63 SLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKI 122 Query: 136 EN--LEALTELEILDISFNLLRN--IEGVDKLTRLKKLFLVNNKISKIE----NLSNLHQ 187 +N L LD+S N L + + +L L++L L NNKI ++ ++ Sbjct: 123 KNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSS 182 Query: 188 LQMLELGSNRIRAIEN--IDTLTNLESLFLGKNKITKLQNLDAL-----TNLTVLSMQSN 240 L+ LEL SN+I+ + L LFL ++ T++ LS+ ++ Sbjct: 183 LKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNS 242 Query: 241 RLTKIEGLQNL----VNLRELYLSHNGIEVI--EGLENNNKLTMLDIASNRIKKI--ENI 292 +L+ L NL L LS+N + V+ + +L + N I+ + ++ Sbjct: 243 QLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSL 302 Query: 293 SHLTELQEFWMNDNLLESWSDLDELKG--------ARSLETVYLERNPLQKDPQYRRKVM 344 L ++ + + + L L + LE + +E N + P + + Sbjct: 303 HGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDI---PGIKSNMF 359 Query: 345 LALPSVRQI 353 L +++ + Sbjct: 360 TGLINLKYL 368 Score = 77.1 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 51/241 (21%), Positives = 93/241 (38%), Gaps = 30/241 (12%) Query: 100 VKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQIK---KIENLEALTELEILDISFNLL 154 + L L +N I IE+ L L LDL N+I + L + + +S+N Sbjct: 393 LHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKY 452 Query: 155 RNI--EGVDKLTRLKKLFLVNNKISKIE----NLSNLHQLQMLELGSN--------RIRA 200 + + L++L L + ++ L L +L+L +N + Sbjct: 453 LQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEG 512 Query: 201 IENIDTL----TNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIE--GLQNLVNL 254 +E ++ L NL L+ N + L L++L +L+++SN +I ++L L Sbjct: 513 LEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFEL 572 Query: 255 RELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKKIENISHLT---ELQEFWMNDNLLE 309 + + L N + + N L L++ N I +E L E M N + Sbjct: 573 KIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFD 632 Query: 310 S 310 Sbjct: 633 C 633 Score = 75.6 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 56/264 (21%), Positives = 105/264 (39%), Gaps = 48/264 (18%) Query: 120 QSLRELDLYDNQIKKIE--NLEALTELEILDISFNLLRNIEG--VDKLTRLKKLFLVNNK 175 ++ L+L NQ++++ N ++L LD+ FN + +E KL LK L L +N+ Sbjct: 35 TNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNE 94 Query: 176 ISKIEN--LSNLHQLQMLELGSNRIRAI--ENIDTLTNLESLFLGKNKIT---------- 221 +S++ + + L L L SN I+ I NL +L L N ++ Sbjct: 95 LSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQL 154 Query: 222 -----------KLQNLDALT-------NLTVLSMQSNRLTKIE--GLQNLVNLRELYLSH 261 K+Q L + +L L + SN++ + + L L+L++ Sbjct: 155 ENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNN 214 Query: 262 NGIEVIEGLENNNKL-----TMLDIASNRIKKIENISHL----TELQEFWMNDNLLESWS 312 + + +L L ++++++ N + L T L ++ N L Sbjct: 215 VQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVG 274 Query: 313 DLDELKGARSLETVYLERNPLQKD 336 + D LE +LE N +Q Sbjct: 275 N-DSFAWLPQLEYFFLEYNNIQHL 297 Score = 71.7 bits (174), Expect = 5e-13, Method: Composition-based stats. Identities = 56/219 (25%), Positives = 98/219 (44%), Gaps = 18/219 (8%) Query: 145 EILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE--NLSNLHQLQMLELGSNRIRAIE 202 E+ D S L + D T + L L +N++ ++ N + QL L++G N I +E Sbjct: 17 EVADCSHLKLTQVPD-DLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLE 75 Query: 203 N--IDTLTNLESLFLGKNKITKLQN--LDALTNLTVLSMQSNRLTKIE--GLQNLVNLRE 256 L L+ L L N++++L + TNLT L + SN + KI+ NL Sbjct: 76 PELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLIT 135 Query: 257 LYLSHNGIEV--IEGLENNNKLTMLDIASNRIKKIE----NISHLTELQEFWMNDNLLES 310 L LSHNG+ + L L +++N+I+ ++ +I + L++ ++ N ++ Sbjct: 136 LDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKE 195 Query: 311 WSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPS 349 +S R L N +Q P K+ L L + Sbjct: 196 FSPGCFHAIGRLFG---LFLNNVQLGPSLTEKLCLELAN 231 Score = 34.0 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 19/70 (27%), Positives = 33/70 (47%), Gaps = 3/70 (4%) Query: 64 ELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIE---NLEELQ 120 E+PV++ + D+ LN+ F +K+L L++NLI +E + Sbjct: 560 EIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFR 619 Query: 121 SLRELDLYDN 130 +L ELD+ N Sbjct: 620 NLTELDMRFN 629 >3JB9-j nrPDB Length = 239 Score = 86.4 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 38/158 (24%), Positives = 63/158 (39%), Gaps = 30/158 (18%) Query: 103 LCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDK 162 + L + + + ELDL QI IENL L ++ Sbjct: 1 MRLNAEFLSQVPSFISPLKETELDLRWYQIPIIENLGVLRDVHD---------------- 44 Query: 163 LTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIEN--IDTLTNLESLFLGKNKI 220 + +N I + N + +LQ L G+NRI AI L NL++L L +N + Sbjct: 45 -----AIDFTDNDIRYLGNFPRMKRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHL 99 Query: 221 TKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELY 258 ++ +LD L + +LT + + N V ++ Y Sbjct: 100 QEIADLDPLASCP-------QLTNLSCIDNPVAQKQYY 130 Score = 73.3 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 34/150 (22%), Positives = 65/150 (43%), Gaps = 3/150 (2%) Query: 213 LFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNL-RELYLSHNGIEVIEGLE 271 + L ++++ + + T L ++ ++ IE L L ++ + + N I + Sbjct: 1 MRLNAEFLSQVPSFISPLKETELDLRWYQIPIIENLGVLRDVHDAIDFTDNDIRYLGNFP 60 Query: 272 NNNKLTMLDIASNRIKKI-ENISH-LTELQEFWMNDNLLESWSDLDELKGARSLETVYLE 329 +L L +NRI I +I L L+ + N L+ +DLD L L + Sbjct: 61 RMKRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIADLDPLASCPQLTNLSCI 120 Query: 330 RNPLQKDPQYRRKVMLALPSVRQIDATFVR 359 NP+ + YR ++ +PS+ +D VR Sbjct: 121 DNPVAQKQYYRLYLIWRIPSLHILDFERVR 150 Score = 44.8 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 40/179 (22%), Positives = 65/179 (36%), Gaps = 31/179 (17%) Query: 80 DVDLNHYRIGKIEGFEVLKKVK-TLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENL 138 ++DL Y+I IE VL+ V + N I+ + N ++ L+ L +N+I I Sbjct: 22 ELDLRWYQIPIIENLGVLRDVHDAIDFTDNDIRYLGNFPRMKRLQTLLCGNNRITAIAP- 80 Query: 139 EALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRI 198 + L LK L L N + +I +L L L + Sbjct: 81 -------------------DIGKVLPNLKTLSLAQNHLQEIADLDPLASCPQL----TNL 117 Query: 199 RAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLREL 257 I+N L+L I ++ +L L V + RL E + N E+ Sbjct: 118 SCIDNPVAQKQYYRLYL----IWRIPSLHILDFERVRR--NERLRAEEVFGQIQNPTEI 170 >5GY2-A nrPDB Length = 455 Score = 81.0 bits (198), Expect = 7e-16, Method: Composition-based stats. Identities = 67/287 (23%), Positives = 114/287 (39%), Gaps = 45/287 (15%) Query: 94 FEVLKKVKTLCLRQNLIKCIENLEELQSLRE---LDLYDNQIK-----KIENLEA----L 141 F+ L ++ L LR N IK I+ ++R LDL N++K + N + L Sbjct: 125 FKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLTFNKVKSICEEDLLNFQGKHFTL 184 Query: 142 TELEILDISFNLL-----RNIEGVDKLTRLKKLFLVNNKISK--IENLSNL---HQLQML 191 L + + K T + L L N + + + ++Q L Sbjct: 185 LRLSSITLQDMNEYWLGWEKCGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAGTKIQSL 244 Query: 192 ELGSN----RIRAIENIDTLTN----------LESLFLGKNKITKL--QNLDALTNLTVL 235 L ++ N N +++ L K+KI L T+L L Sbjct: 245 ILSNSYNMGSSFGHTNFKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDLEQL 304 Query: 236 SMQSNRLTKIE--GLQNLVNLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKKIEN 291 ++ N + KI+ L +L +L LS N + I+ EN +KL +LD++ N I+ + + Sbjct: 305 TLAQNEINKIDDNAFWGLTHLLKLNLSQNFLGSIDSRMFENLDKLEVLDLSYNHIRALGD 364 Query: 292 ISHL--TELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKD 336 S L L+E ++ N L+S D SL+ ++L NP Sbjct: 365 QSFLGLPNLKELALDTNQLKSVPD-GIFDRLTSLQKIWLHTNPWDCS 410 Score = 69.0 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 68/345 (19%), Positives = 121/345 (35%), Gaps = 75/345 (21%) Query: 80 DVDLNHYRIGKIEGFEVLKKVKTLCLRQN---LIKCIENLEELQSLRELDLYDNQIKKIE 136 D+ LN F L+ ++ L + Q L+ L SL L L NQ ++E Sbjct: 36 DLSLNSIAELNETSFSRLQDLQFLKVEQQTPGLVIRNNTFRGLSSLIILKLDYNQFLQLE 95 Query: 137 --NLEALTELEILDISFNLLR----NIEGVDKLTRLKKLFLVNNKISKIEN---LSNLHQ 187 L LE+L ++ L + LT L+ L L +N I KI+ N+ + Sbjct: 96 TGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRR 155 Query: 188 LQMLELGSNRIRAIENIDTLT----NLESLFLGKNKITKLQNL----------DALTNLT 233 +L+L N++++I D L + L L + + T++T Sbjct: 156 FHVLDLTFNKVKSICEEDLLNFQGKHFTLLRLSSITLQDMNEYWLGWEKCGNPFKNTSIT 215 Query: 234 VLSMQSNRLTKI-------------------------------EGLQNLVN--------- 253 L + N + ++ N Sbjct: 216 TLDLSGNGFKESMAKRFFDAIAGTKIQSLILSNSYNMGSSFGHTNFKDPDNFTFKGLEAS 275 Query: 254 -LRELYLSHNGIEVI--EGLENNNKLTMLDIASNRIKKIENISH--LTELQEFWMNDNLL 308 ++ LS + I + + L L +A N I KI++ + LT L + ++ N L Sbjct: 276 GVKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFWGLTHLLKLNLSQNFL 335 Query: 309 ESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQI 353 S D + LE + L N ++ L LP+++++ Sbjct: 336 GSI-DSRMFENLDKLEVLDLSYNHIRALGDQSF---LGLPNLKEL 376 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 50/260 (19%), Positives = 99/260 (38%), Gaps = 39/260 (15%) Query: 112 CIENLEELQ-SLRELDLYDNQIKKIEN-----LEALTELEILDISFNLLRNIEGVDKLTR 165 + + EL + +DL N I ++ L+ L L++ + L+ L+ Sbjct: 21 GLHQVPELPAHVNYVDLSLNSIAELNETSFSRLQDLQFLKVEQQTPGLVIRNNTFRGLSS 80 Query: 166 LKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRIRAI----ENIDTLTNLESLFLGKNK 219 L L L N+ ++E + L L++L L + LT+LE L L N Sbjct: 81 LIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNN 140 Query: 220 ITKLQN---LDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIE-------- 268 I K+Q + VL + N++ I ++L+N + + + + I Sbjct: 141 IKKIQPASFFLNMRRFHVLDLTFNKVKSI-CEEDLLNFQGKHFTLLRLSSITLQDMNEYW 199 Query: 269 -------GLENNNKLTMLDIASNRI-----KKIENISHLTELQEFWMND--NLLESWSDL 314 N +T LD++ N K+ + T++Q +++ N+ S+ Sbjct: 200 LGWEKCGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAGTKIQSLILSNSYNMGSSFGHT 259 Query: 315 DELKGARSLETVYLERNPLQ 334 + K + LE + ++ Sbjct: 260 N-FKDPDNFTFKGLEASGVK 278 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 19/61 (31%), Positives = 32/61 (52%), Gaps = 3/61 (4%) Query: 73 NLDR-DAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIEN--LEELQSLRELDLYD 129 NLD+ + D+ NH R + F L +K L L N +K + + + L SL+++ L+ Sbjct: 345 NLDKLEVLDLSYNHIRALGDQSFLGLPNLKELALDTNQLKSVPDGIFDRLTSLQKIWLHT 404 Query: 130 N 130 N Sbjct: 405 N 405 >4PUF-A nrPDB Length = 637 Score = 78.7 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 43/215 (20%), Positives = 94/215 (43%), Gaps = 17/215 (7%) Query: 81 VDLNHYRIGKIEGFEVLK-KVKTLCLRQNLIKCIEN-LEELQSLRELDLYDNQIKKIENL 138 + L++ + + E L+ +KTL N + I L + +++E++L N+I ++ Sbjct: 76 LILDNNELKSL--PENLQGNIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPE- 130 Query: 139 EALTELEILDISFNLLRNIEGVDKLTR-LKKLFLVNNKISKIENLSNLHQ-LQMLELGSN 196 + L+ LD+ N + + + L L+ L + +N I + ++L + L + SN Sbjct: 131 RLPSALQSLDLFHNKISCLP--ENLPEELRYLSVYDNSIRTLP--AHLPSEITHLNVQSN 186 Query: 197 RIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRE 256 + A+ L++L G+N +T L L VL + N++T + + Sbjct: 187 SLTALPE-TLPPGLKTLEAGENALTSLPA-SLPPELQVLDVSKNQITVLPETLPPT-ITT 243 Query: 257 LYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIEN 291 L +S N + + L ++ + N + ++ Sbjct: 244 LDVSRNALTNLPE-NLPAALQIMQASRNNLVRLPE 277 >3A7C-A nrPDB Length = 580 Score = 78.3 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 47/180 (26%), Positives = 77/180 (42%), Gaps = 15/180 (8%) Query: 139 EALTELEILDISFNL-----LRNIEGVDKLTRLKKLFLVNNKISKIEN----LSNLHQLQ 189 + L LE LD+S NL L+N L+ L L N + ++ L L L Sbjct: 357 QHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILLTLKNLT 416 Query: 190 MLELGSNRIRAIENI-DTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGL 248 L++ N + + + L L I ++ T L VL + +N L Sbjct: 417 SLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQT-LEVLDVSNNNLDSFSLF 475 Query: 249 QNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIEN--ISHLTELQEFWMNDN 306 L L+ELY+S N ++ + L ++ IASN++K + + LT LQ+ W++ N Sbjct: 476 --LPRLQELYISRNKLKTLPDASLFPVLLVMKIASNQLKSVPDGIFDRLTSLQKIWLHTN 533 Score = 76.3 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 41/186 (22%), Positives = 72/186 (38%), Gaps = 14/186 (7%) Query: 161 DKLTRLKKLFLVNN-----KISKIENLSNLHQLQMLELGSNRIRAI----ENIDTLTNLE 211 L L+ L L N + LQ L L N +R++ E + TL NL Sbjct: 357 QHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILLTLKNLT 416 Query: 212 SLFLGKNKITKLQN-LDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGL 270 SL + +N + + + L++ S + ++ L L +S+N ++ Sbjct: 417 SLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCI-PQTLEVLDVSNNNLDSFSLF 475 Query: 271 ENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLER 330 +L L I+ N++K + + S L + N L+S D SL+ ++L Sbjct: 476 --LPRLQELYISRNKLKTLPDASLFPVLLVMKIASNQLKSVPD-GIFDRLTSLQKIWLHT 532 Query: 331 NPLQKD 336 NP Sbjct: 533 NPWDCS 538 Score = 56.7 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 54/275 (19%), Positives = 103/275 (37%), Gaps = 21/275 (7%) Query: 77 DAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRE-LDLYDNQIKK- 134 + D +L ++ + EV +K L R +++ E L+ LR L+L + + Sbjct: 228 ELRDTNLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILELSEVEFDDC 287 Query: 135 -IENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLEL 193 + L E +S + +L + + +S + +L + +E Sbjct: 288 TLNGLGDFNPSESDVVSELGKVETVTIRRLHIPQFYLFYD--LSTVYSLLEKVKRITVEN 345 Query: 194 GSNRIRAIENIDTLTNLESLFLGKN-----KITKLQNLDALTNLTVLSMQSNRLTKI--- 245 + L +LE L L +N + A +L L + N L + Sbjct: 346 SKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKT 405 Query: 246 -EGLQNLVNLRELYLSHNGIEVIEGLEN-NNKLTMLDIASNRIKKIENISHLTELQEFWM 303 E L L NL L +S N + K+ L+++S I ++ L+ + Sbjct: 406 GEILLTLKNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGI-RVVKTCIPQTLEVLDV 464 Query: 304 NDNLLESWSDLDELKGARSLETVYLERNPLQKDPQ 338 ++N L+S+S L+ +Y+ RN L+ P Sbjct: 465 SNNNLDSFS-----LFLPRLQELYISRNKLKTLPD 494 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 35/151 (23%), Positives = 66/151 (43%), Gaps = 9/151 (5%) Query: 209 NLESLFLGKNKITKLQ--NLDALTNLTVLSMQSNRLTKIE--GLQNLVNLRELYLSHNGI 264 ++SL L NKIT + +L A NL VL ++S+R+ IE +L +L L LS N + Sbjct: 53 AMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHL 112 Query: 265 EVI--EGLENNNKLTMLDIASNRIKKIENISHLTELQEFW-MNDNLLESWSDLD--ELKG 319 + + L L++ N + + S L + +E++S++ + G Sbjct: 113 SSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVETFSEIRRIDFAG 172 Query: 320 ARSLETVYLERNPLQKDPQYRRKVMLALPSV 350 SL + ++ L+ K + + + Sbjct: 173 LTSLNELEIKALSLRNYQSQSLKSIRDIHHL 203 Score = 55.2 bits (131), Expect = 5e-08, Method: Composition-based stats. Identities = 38/202 (18%), Positives = 79/202 (39%), Gaps = 28/202 (13%) Query: 121 SLRELDLYDNQIKKIE--NLEALTELEILDISFNLLRNIEG--VDKLTRLKKLFLVNNKI 176 +++ LDL N+I I +L A L++L + + + IEG L L+ L L +N + Sbjct: 53 AMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHL 112 Query: 177 SKIEN--LSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTV 234 S + + L L+ L L N + + NL +L +I ++ + + Sbjct: 113 SSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQ--TLRIGNVETFSEIRRI-- 168 Query: 235 LSMQSNRLTKIEGLQNLVNLRELYLSHNGI-----EVIEGLENNNKLTMLDIASNRIKKI 289 L +L EL + + + ++ + + + LT L ++ + Sbjct: 169 ------------DFAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLT-LHLSESAFLLE 215 Query: 290 ENISHLTELQEFWMNDNLLESW 311 L+ ++ + D L + Sbjct: 216 IFADILSSVRYLELRDTNLARF 237 Score = 52.9 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 54/330 (16%), Positives = 102/330 (30%), Gaps = 70/330 (21%) Query: 77 DAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQN---LIKCIENLEELQSLRELDLYD---- 129 + D+ NH F L +K L L N + L +L+ L + + Sbjct: 103 EHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVETF 162 Query: 130 NQIKKIENLEALTELEILDISFNLLRN-----IEGVDKLTRLKKLFLVNNK-----ISKI 179 ++I++I+ LT L L+I LRN ++ + + L L L + + I Sbjct: 163 SEIRRID-FAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLT-LHLSESAFLLEIFADI 220 Query: 180 ENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVL---- 235 + +L+ L + + + + ++ L + +T + L L + Sbjct: 221 LSSVRYLELRDTNLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILELS 280 Query: 236 -----SMQSNRLT------------------------KIEGLQNLVNLRELYL------- 259 N L I +L +Y Sbjct: 281 EVEFDDCTLNGLGDFNPSESDVVSELGKVETVTIRRLHIPQFYLFYDLSTVYSLLEKVKR 340 Query: 260 -----SHNGIEVIEGLENNNKLTMLDIASN-----RIKKIENISHLTELQEFWMNDNLLE 309 S + ++ L LD++ N +K LQ ++ N L Sbjct: 341 ITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLR 400 Query: 310 SWSDLDE-LKGARSLETVYLERNPLQKDPQ 338 S E L ++L ++ + RN P Sbjct: 401 SMQKTGEILLTLKNLTSLDISRNTFHPMPD 430 >2Z80-A nrPDB Length = 353 Score = 77.5 bits (189), Expect = 9e-15, Method: Composition-based stats. Identities = 62/269 (23%), Positives = 117/269 (43%), Gaps = 34/269 (12%) Query: 98 KKVKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQIKKIE--NLEALTELEILDISFNL 153 + VK+L L N I I N L+ +L+ L L N I IE + +L LE LD+S+N Sbjct: 52 EAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNY 111 Query: 154 LRNIEG--VDKLTRLKKLFLVNNKISKIEN---LSNLHQLQMLELGS----NRIRAIENI 204 L N+ L+ L L L+ N + S+L +LQ+L +G+ +I+ ++ Sbjct: 112 LSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQR-KDF 170 Query: 205 DTLTNLESLFLGKNKITKLQN--LDALTNLTVLSMQSNR-LTKIEGLQNLV-NLRELYLS 260 LT LE L + + + + L ++ N++ L + + + +E ++ ++ L L Sbjct: 171 AGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELR 230 Query: 261 HNGIEVIEGLEN-------------NNKLTMLDIASNRIKKIENISHLTELQEFWMNDNL 307 ++ E + + D + ++ K+ ++ ++ L E + N Sbjct: 231 DTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKL--LNQISGLLELEFSRNQ 288 Query: 308 LESWSDLDELKGARSLETVYLERNPLQKD 336 L+S D SL+ ++L NP Sbjct: 289 LKSVPD-GIFDRLTSLQKIWLHTNPWDCS 316 Score = 49.8 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 35/210 (16%), Positives = 74/210 (35%), Gaps = 23/210 (10%) Query: 77 DAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDL----YDNQI 132 + D+ N+ F+ L + L L N K + L +L + + Sbjct: 103 EHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTF 162 Query: 133 KKIE--NLEALTELEILDISFNLLRN--IEGVDKLTRLKKLFLVNNK-------ISKIEN 181 KI+ + LT LE L+I + L++ + + + + L L + + + Sbjct: 163 TKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTS 222 Query: 182 LSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLT------VL 235 +L+ +L + + +T + ++ KIT + L L Sbjct: 223 SVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLEL 282 Query: 236 SMQSNRLTKIEG--LQNLVNLRELYLSHNG 263 N+L + L +L++++L N Sbjct: 283 EFSRNQLKSVPDGIFDRLTSLQKIWLHTNP 312 >3V44-A nrPDB Length = 407 Score = 74.8 bits (182), Expect = 5e-14, Method: Composition-based stats. Identities = 67/328 (20%), Positives = 115/328 (35%), Gaps = 72/328 (21%) Query: 80 DVDLNHYRIGKIEGFEVLKKVKTLCLRQN---LIKCIENLEELQSLRELDLYDNQIKKIE 136 D+ LN F L+ ++ L + Q L+ L SL L L NQ ++E Sbjct: 36 DLSLNSIAELNETSFSRLQDLQFLKVEQQTPGLVIRNNTFRGLSSLIILKLDYNQFLQLE 95 Query: 137 --NLEALTELEILDISFNLLR----NIEGVDKLTRLKKLFLVNNKISKIEN---LSNLHQ 187 L LE+L ++ L + LT L+ L L +N I KI+ N+ + Sbjct: 96 TGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRR 155 Query: 188 LQMLELGSNRIRAIENIDTLT----NLESLFLGKNKITKLQNL----------DALTNLT 233 +L+L N++++I D L + L L + + T++T Sbjct: 156 FHVLDLTFNKVKSICEEDLLNFQGKHFTLLRLSSITLQDMNEYWLGWEKCGNPFKNTSIT 215 Query: 234 VLSMQSNRLTKI-------------------------------EGLQNLVN--------- 253 L + N + ++ N Sbjct: 216 TLDLSGNGFKESMAKRFFDAIAGTKIQSLILSNSYNMGSSFGHTNFKDPDNFTFKGLEAS 275 Query: 254 -LRELYLSHNGIEVI--EGLENNNKLTMLDIASNRIKKIENISH--LTELQEFWMNDNLL 308 ++ LS + I + + L L +A N I KI++ + LT L+E ++ N L Sbjct: 276 GVKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFWGLTHLKELALDTNQL 335 Query: 309 ESWSDLDELKGARSLETVYLERNPLQKD 336 +S D SL+ ++L NP Sbjct: 336 KSVPD-GIFDRLTSLQKIWLHTNPWDCS 362 Score = 55.9 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 50/260 (19%), Positives = 99/260 (38%), Gaps = 39/260 (15%) Query: 112 CIENLEELQ-SLRELDLYDNQIKKIEN-----LEALTELEILDISFNLLRNIEGVDKLTR 165 + + EL + +DL N I ++ L+ L L++ + L+ L+ Sbjct: 21 GLHQVPELPAHVNYVDLSLNSIAELNETSFSRLQDLQFLKVEQQTPGLVIRNNTFRGLSS 80 Query: 166 LKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRIRAI----ENIDTLTNLESLFLGKNK 219 L L L N+ ++E + L L++L L + LT+LE L L N Sbjct: 81 LIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNN 140 Query: 220 ITKLQN---LDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIE-------- 268 I K+Q + VL + N++ I ++L+N + + + + I Sbjct: 141 IKKIQPASFFLNMRRFHVLDLTFNKVKSI-CEEDLLNFQGKHFTLLRLSSITLQDMNEYW 199 Query: 269 -------GLENNNKLTMLDIASNRI-----KKIENISHLTELQEFWMND--NLLESWSDL 314 N +T LD++ N K+ + T++Q +++ N+ S+ Sbjct: 200 LGWEKCGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAGTKIQSLILSNSYNMGSSFGHT 259 Query: 315 DELKGARSLETVYLERNPLQ 334 + K + LE + ++ Sbjct: 260 N-FKDPDNFTFKGLEASGVK 278 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 30/128 (23%), Positives = 51/128 (39%), Gaps = 15/128 (11%) Query: 106 RQNLIKCIENLE----ELQSLRELDLYDNQIKKIEN--LEALTELEILDISFNLLRNIE- 158 K +N E ++ DL ++I + T+LE L ++ N + I+ Sbjct: 257 GHTNFKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDD 316 Query: 159 -GVDKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRIRA-IENIDTLTNLESLF 214 LT LK+L L N++ + + L LQ + L +N ID L+ + Sbjct: 317 NAFWGLTHLKELALDTNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLSR----W 372 Query: 215 LGKNKITK 222 L KN + Sbjct: 373 LNKNSQKE 380 >2V9T-B nrPDB Length = 220 Score = 70.2 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 44/167 (26%), Positives = 69/167 (41%), Gaps = 16/167 (9%) Query: 109 LIKCIENLEELQSLRELDLYDNQIKKIEN--LEALTELEILDISFNLLRNI--EGVDKLT 164 L + NL E ++ E+ L N IK I +L +D+S N + + + L Sbjct: 23 LTEIPTNLPE--TITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLR 80 Query: 165 RLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRIRAI--ENIDTLTNLESLFLGKNKI 220 L L L NKI+++ L LQ+L L +N+I + + L NL L L NK+ Sbjct: 81 SLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKL 140 Query: 221 TKLQN--LDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIE 265 + L + + + N L+ L + YL N IE Sbjct: 141 QTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLAD----YLHTNPIE 183 Score = 47.8 bits (112), Expect = 7e-06, Method: Composition-based stats. Identities = 27/145 (18%), Positives = 56/145 (38%), Gaps = 8/145 (5%) Query: 220 ITKLQNLDALTNLTVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGIEVIEG--LENNNK 275 +T++ + +T + ++ N + I LR + LS+N I + + Sbjct: 23 LTEIPT-NLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRS 81 Query: 276 LTMLDIASNRIKKIEN--ISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPL 333 L L + N+I ++ L LQ +N N + +D + +L + L N L Sbjct: 82 LNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCL-RVDAFQDLHNLNLLSLYDNKL 140 Query: 334 QKDPQYRRKVMLALPSVRQIDATFV 358 Q + + A+ ++ F+ Sbjct: 141 QTIAKGTFSPLRAIQTMHLAQNPFI 165 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 33/148 (22%), Positives = 52/148 (35%), Gaps = 32/148 (21%) Query: 80 DVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQIKKIEN 137 D+ N + F+ L+ + +L L N I + E L SL+ L L N+I + Sbjct: 62 DLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCL-- 119 Query: 138 LEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI--ENLSNLHQLQMLELGS 195 ++ L L L L +NK+ I S L +Q + L Sbjct: 120 ------------------RVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQ 161 Query: 196 NRIRAIENIDTLTNLESL--FLGKNKIT 221 N +L+ L +L N I Sbjct: 162 NPFIC------DCHLKWLADYLHTNPIE 183 >3B2D-A nrPDB Length = 603 Score = 68.6 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 66/333 (19%), Positives = 128/333 (38%), Gaps = 58/333 (17%) Query: 75 DRDAEDVDLNHYRIGKIEGFEVLK--KVKTLCLRQNLIKCIE-----NLEELQSLRELDL 127 + E + L I I+ + +K L + N I I +LE+ +L L+ Sbjct: 125 LENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINL-SLNF 183 Query: 128 YDNQIKKIE------------NLEALTELEIL------------------DISFNLLRN- 156 N +K IE N L ++ DI + + Sbjct: 184 NGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSA 243 Query: 157 -IEGVDKLTRLKKLFLVNNKISKI--ENLSNLHQLQMLELGSNRIRAIE-NIDTLTNLES 212 ++G+ ++ ++ L L ++ S I QLQ L+L + ++ + + L L+ Sbjct: 244 MLKGLCEM-SVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKK 302 Query: 213 LFLGKNKITKLQNLD--ALTNLTVLSMQSNRLTK---IEGLQNLVNLRELYLSHNGIEVI 267 L L N +L + +LT L ++ N + L+ L NL+ L LSHN IE Sbjct: 303 LVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEAS 362 Query: 268 E----GLENNNKLTMLDIASNRIKKIENIS--HLTELQEFWMNDNLLESWSDLDELKGAR 321 + L+N + L L+++ N +++ + +L+ + L + + Sbjct: 363 DCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLH 422 Query: 322 SLETVYLERNPLQKDPQYRRKVMLALPSVRQID 354 L+ + L L Q+ ++ LP +R ++ Sbjct: 423 FLQVLNLTYCFLDTSNQH---LLAGLPVLRHLN 452 Score = 59.0 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 64/335 (19%), Positives = 120/335 (35%), Gaps = 70/335 (20%) Query: 70 ETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIE--NLEELQSLRELDL 127 +T+ + + N F L + L L + I I + L L L Sbjct: 26 DTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVL 85 Query: 128 YDNQIKKIE--NLEALTELEILDISFNLLRNIEGVD--KLTRLKKLFLVNNKISKIENLS 183 N + + +L L+ L + + N+E + L L+ L+L +N IS I+ Sbjct: 86 TGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPK 145 Query: 184 NLH--QLQMLELGSNRIRAI--ENIDTLTNLESLFLGKN----KITKLQNLD-------- 227 + L++L+ +N I I E++ +L +L L N K +L D Sbjct: 146 DFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLN 205 Query: 228 --ALTNLTV-----------------------------------------LSMQSNRLTK 244 NL+V L++Q +R + Sbjct: 206 FGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSD 265 Query: 245 IEG--LQNLVNLRELYLSHNGIEVIE-GLENNNKLTMLDIASNRIKKIENISH--LTELQ 299 I Q L+EL L+ ++ + G++ N L L ++ N ++ IS L Sbjct: 266 ISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLT 325 Query: 300 EFWMNDNLLESWSDLDELKGARSLETVYLERNPLQ 334 ++ N+ + + L+ +L+T+ L N ++ Sbjct: 326 HLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIE 360 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 31/184 (16%), Positives = 73/184 (39%), Gaps = 17/184 (9%) Query: 77 DAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSL---RELDLYDNQIK 133 ++ N + + F+ +++ L L + Q+L + L+L + Sbjct: 376 QTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLD 435 Query: 134 KIEN--LEALTELEILDISFN-----LLRNIEGVDKLTRLKKLFLVNNKISKI--ENLSN 184 L L L L++ N + + + L+ L L + + I + + Sbjct: 436 TSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHS 495 Query: 185 LHQLQMLELGSNRIRAIENIDTLTNLESLFLG--KNKITKLQN--LDALTNLTVLSMQSN 240 L ++ ++L N + ++ID+L++L+ ++L N I + L L+ + +++ N Sbjct: 496 LGKMSHVDLSHNSLTC-DSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHN 554 Query: 241 RLTK 244 L Sbjct: 555 PLDC 558 >5D3I-A nrPDB Length = 568 Score = 68.3 bits (165), Expect = 5e-12, Method: Composition-based stats. Identities = 42/191 (21%), Positives = 70/191 (36%), Gaps = 15/191 (7%) Query: 139 EALTELEILDISFNL-----LRNIEGVDKLTRLKKLFLVNNKISKIEN----LSNLHQLQ 189 + L LE LD+S NL L+N L+ L L N + ++ L L L Sbjct: 335 QHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILLTLKNLT 394 Query: 190 MLELGSNRIRAIENI-DTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGL 248 L++ N + + + L L I ++ T L VL + +N L Sbjct: 395 SLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQT-LEVLDVSNNNLDSFSLF 453 Query: 249 QNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIE--NISHLTELQEFWMNDN 306 L L+ELY+S N ++ + L ++ I N + + +L+ DN Sbjct: 454 --LPRLQELYISRNKLKTLPDASLFPVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDN 511 Query: 307 LLESWSDLDEL 317 +L Sbjct: 512 HFVCSCELLSF 522 Score = 57.1 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 56/289 (19%), Positives = 109/289 (37%), Gaps = 21/289 (7%) Query: 77 DAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRE-LDLYDNQIKK- 134 + D +L ++ + EV +K L R +++ E L+ LR L+L + + Sbjct: 206 ELRDTNLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILELSEVEFDDC 265 Query: 135 -IENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLEL 193 + L E +S + +L + + +S + +L + +E Sbjct: 266 TLNGLGDFNPSESDVVSELGKVETVTIRRLHIPQFYLFYD--LSTVYSLLEKVKRITVEN 323 Query: 194 GSNRIRAIENIDTLTNLESLFLGKN-----KITKLQNLDALTNLTVLSMQSNRLTKI--- 245 + L +LE L L +N + A +L L + N L + Sbjct: 324 SKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKT 383 Query: 246 -EGLQNLVNLRELYLSHNGIEVIEGLEN-NNKLTMLDIASNRIKKIENISHLTELQEFWM 303 E L L NL L +S N + K+ L+++S I ++ L+ + Sbjct: 384 GEILLTLKNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGI-RVVKTCIPQTLEVLDV 442 Query: 304 NDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQ 352 ++N L+S+S L+ +Y+ RN L+ P +L + +R+ Sbjct: 443 SNNNLDSFS-----LFLPRLQELYISRNKLKTLPDASLFPVLLVMKIRE 486 Score = 55.2 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 35/151 (23%), Positives = 66/151 (43%), Gaps = 9/151 (5%) Query: 209 NLESLFLGKNKITKLQ--NLDALTNLTVLSMQSNRLTKIE--GLQNLVNLRELYLSHNGI 264 ++SL L NKIT + +L A NL VL ++S+R+ IE +L +L L LS N + Sbjct: 31 AMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHL 90 Query: 265 EVI--EGLENNNKLTMLDIASNRIKKIENISHLTELQEFW-MNDNLLESWSDLD--ELKG 319 + + L L++ N + + S L + +E++S++ + G Sbjct: 91 SSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVETFSEIRRIDFAG 150 Query: 320 ARSLETVYLERNPLQKDPQYRRKVMLALPSV 350 SL + ++ L+ K + + + Sbjct: 151 LTSLNELEIKALSLRNYQSQSLKSIRDIHHL 181 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 38/202 (18%), Positives = 79/202 (39%), Gaps = 28/202 (13%) Query: 121 SLRELDLYDNQIKKIE--NLEALTELEILDISFNLLRNIEG--VDKLTRLKKLFLVNNKI 176 +++ LDL N+I I +L A L++L + + + IEG L L+ L L +N + Sbjct: 31 AMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHL 90 Query: 177 SKIEN--LSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTV 234 S + + L L+ L L N + + NL +L +I ++ + + Sbjct: 91 SSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQ--TLRIGNVETFSEIRRI-- 146 Query: 235 LSMQSNRLTKIEGLQNLVNLRELYLSHNGI-----EVIEGLENNNKLTMLDIASNRIKKI 289 L +L EL + + + ++ + + + LT L ++ + Sbjct: 147 ------------DFAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLT-LHLSESAFLLE 193 Query: 290 ENISHLTELQEFWMNDNLLESW 311 L+ ++ + D L + Sbjct: 194 IFADILSSVRYLELRDTNLARF 215 Score = 51.3 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 54/330 (16%), Positives = 102/330 (30%), Gaps = 70/330 (21%) Query: 77 DAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQN---LIKCIENLEELQSLRELDLYD---- 129 + D+ NH F L +K L L N + L +L+ L + + Sbjct: 81 EHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVETF 140 Query: 130 NQIKKIENLEALTELEILDISFNLLRN-----IEGVDKLTRLKKLFLVNNK-----ISKI 179 ++I++I+ LT L L+I LRN ++ + + L L L + + I Sbjct: 141 SEIRRID-FAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLT-LHLSESAFLLEIFADI 198 Query: 180 ENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVL---- 235 + +L+ L + + + + ++ L + +T + L L + Sbjct: 199 LSSVRYLELRDTNLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILELS 258 Query: 236 -----SMQSNRLT------------------------KIEGLQNLVNLRELYL------- 259 N L I +L +Y Sbjct: 259 EVEFDDCTLNGLGDFNPSESDVVSELGKVETVTIRRLHIPQFYLFYDLSTVYSLLEKVKR 318 Query: 260 -----SHNGIEVIEGLENNNKLTMLDIASN-----RIKKIENISHLTELQEFWMNDNLLE 309 S + ++ L LD++ N +K LQ ++ N L Sbjct: 319 ITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLR 378 Query: 310 SWSDLDE-LKGARSLETVYLERNPLQKDPQ 338 S E L ++L ++ + RN P Sbjct: 379 SMQKTGEILLTLKNLTSLDISRNTFHPMPD 408 >3A79-B nrPDB Length = 562 Score = 67.9 bits (164), Expect = 7e-12, Method: Composition-based stats. Identities = 46/196 (23%), Positives = 77/196 (39%), Gaps = 19/196 (9%) Query: 143 ELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISK--IENLSNLHQLQMLELGSNRIRA 200 +++L IS ++ + L N + + S L +LQ L L N Sbjct: 332 NIKMLSISDTPFIHMVCPPSPSSFTFLNFTQNVFTDSVFQGCSTLKRLQTLILQRN---- 387 Query: 201 IENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLS 260 L N + L ++ L+ LD +L L+ + T ++ L LS Sbjct: 388 -----GLKNFFKVALMTKNMSSLETLD--VSLNSLNSHAYDRTCAWA----ESILVLNLS 436 Query: 261 HNGIEVIEGLENNNKLTMLDIASNRIKKIE-NISHLTELQEFWMNDNLLESWSDLDELKG 319 N + K+ +LD+ +NRI I +++HL LQE + N L+S D Sbjct: 437 SNMLTGSVFRCLPPKVKVLDLHNNRIMSIPKDVTHLQALQELNVASNQLKSVPD-GVFDR 495 Query: 320 ARSLETVYLERNPLQK 335 SL+ ++L NP Sbjct: 496 LTSLQYIWLHDNPWDC 511 Score = 60.2 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 36/147 (24%), Positives = 73/147 (49%), Gaps = 11/147 (7%) Query: 84 NHYRIGKI-EGFEVLKKVKTLCLRQNLIKCIENL----EELQSLRELDLYDNQIKKIE-- 136 + + +G LK+++TL L++N +K + + + SL LD+ N + Sbjct: 362 QNVFTDSVFQGCSTLKRLQTLILQRNGLKNFFKVALMTKNMSSLETLDVSLNSLNSHAYD 421 Query: 137 -NLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE-NLSNLHQLQMLELG 194 + +L++S N+L ++K L L NN+I I ++++L LQ L + Sbjct: 422 RTCAWAESILVLNLSSNMLTGSVFRCLPPKVKVLDLHNNRIMSIPKDVTHLQALQELNVA 481 Query: 195 SNRIRAIEN--IDTLTNLESLFLGKNK 219 SN+++++ + D LT+L+ ++L N Sbjct: 482 SNQLKSVPDGVFDRLTSLQYIWLHDNP 508 Score = 59.0 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 34/156 (21%), Positives = 61/156 (39%), Gaps = 11/156 (7%) Query: 178 KIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKL--QNLDALTNLTVL 235 + SN +L+ + SNR D ++L L +N I++L ++ L+ L VL Sbjct: 24 SMTPFSN--ELESMVDYSNRNLTHVPKDLPPRTKALSLSQNSISELRMPDISFLSELRVL 81 Query: 236 SMQSNRLTKIE--GLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENIS 293 + NR+ ++ +L L +SHN ++ I L LD++ N + Sbjct: 82 RLSHNRIRSLDFHVFLFNQDLEYLDVSHNRLQNISCCP-MASLRHLDLSFNDFDVLPVCK 140 Query: 294 HLTELQEFWMNDNLLESWSDLDELKGARSLETVYLE 329 L + + LD L A ++L Sbjct: 141 EFGNLTKLTFLGLSAAKFRQLDLLPVA----HLHLS 172 Score = 57.5 bits (137), Expect = 9e-09, Method: Composition-based stats. Identities = 42/192 (21%), Positives = 75/192 (39%), Gaps = 12/192 (6%) Query: 77 DAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCI--ENLEELQSLRELDLYDNQIKK 134 A + N ++ L +++ L L N I+ + Q L LD+ N+++ Sbjct: 55 KALSLSQNSISELRMPDISFLSELRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRLQN 114 Query: 135 IENLEALTELEILDISFNLLRNIE---GVDKLTRLKKLFLVNNKISKIENLSNLH---QL 188 I + + L LD+SFN + LT+L L L K +++ L H Sbjct: 115 I-SCCPMASLRHLDLSFNDFDVLPVCKEFGNLTKLTFLGLSAAKFRQLDLLPVAHLHLSC 173 Query: 189 QMLELGSNRIRAIENID---TLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKI 245 +L+L S I+ E T + L N + +Q ++ L L + + +L Sbjct: 174 ILLDLVSYHIKGGETESLQIPNTTVLHLVFHPNSLFSVQVNMSVNALGHLQLSNIKLNDE 233 Query: 246 EGLQNLVNLREL 257 + + L EL Sbjct: 234 NCQRLMTFLSEL 245 Score = 56.7 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 33/132 (25%), Positives = 50/132 (37%), Gaps = 6/132 (4%) Query: 169 LFLVNNKISKIENLSNLHQLQMLELGSNRIRAI--ENIDTLTNLESLFLGKNKITKLQNL 226 + N ++ + + + L L N I + +I L+ L L L N+I L Sbjct: 36 VDYSNRNLTHVPKDLP-PRTKALSLSQNSISELRMPDISFLSELRVLRLSHNRIRSLDFH 94 Query: 227 DALTN--LTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASN 284 L N L L + NRL I + +LR L LS N +V+ + LT L Sbjct: 95 VFLFNQDLEYLDVSHNRLQNISCCP-MASLRHLDLSFNDFDVLPVCKEFGNLTKLTFLGL 153 Query: 285 RIKKIENISHLT 296 K + L Sbjct: 154 SAAKFRQLDLLP 165 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 29/133 (21%), Positives = 51/133 (38%), Gaps = 5/133 (3%) Query: 208 TNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKI--EGLQNLVNLRELYLSHNGIE 265 LES+ N+ D LS+ N ++++ + L LR L LSHN I Sbjct: 30 NELESMVDYSNRNLTHVPKDLPPRTKALSLSQNSISELRMPDISFLSELRVLRLSHNRIR 89 Query: 266 VIEG--LENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSL 323 ++ N L LD++ NR++ I + L+ ++ N + E L Sbjct: 90 SLDFHVFLFNQDLEYLDVSHNRLQNISCCP-MASLRHLDLSFNDFDVLPVCKEFGNLTKL 148 Query: 324 ETVYLERNPLQKD 336 + L ++ Sbjct: 149 TFLGLSAAKFRQL 161 Score = 52.1 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 39/209 (18%), Positives = 81/209 (38%), Gaps = 28/209 (13%) Query: 145 EILDISFNLLRNI--EGVDKLTRLKKLFLVNNKISKIE--NLSNLHQLQMLELGSNRIRA 200 + L +S N + + + L+ L+ L L +N+I ++ L+ L++ NR++ Sbjct: 55 KALSLSQNSISELRMPDISFLSELRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRLQN 114 Query: 201 IENIDTLTNLESLFLGKNKITKLQ---NLDALTNLTVLSMQSNRLTKIEGLQNLVNLREL 257 I + +L L L N L LT LT L + + + +++ L + L Sbjct: 115 ISCC-PMASLRHLDLSFNDFDVLPVCKEFGNLTKLTFLGLSAAKFRQLDLLP----VAHL 169 Query: 258 YLSHNGIEVIE--------GLENNNKLTMLDIAS--NRIKKIENISHLTELQEFWMNDNL 307 +LS ++++ T+L + N + ++ + L +++ Sbjct: 170 HLSCILLDLVSYHIKGGETESLQIPNTTVLHLVFHPNSLFSVQVNMSVNALGHLQLSNIK 229 Query: 308 LES------WSDLDELKGARSLETVYLER 330 L + L EL +L V L+ Sbjct: 230 LNDENCQRLMTFLSELTRGPTLLNVTLQH 258 Score = 51.3 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 39/179 (21%), Positives = 72/179 (40%), Gaps = 14/179 (7%) Query: 69 METINLDRDAEDVDLNHYRIGKIEGFEVL--KKVKTLCLRQNLIKCIENLEELQSLRELD 126 M I+ + + L+H RI ++ L + ++ L + N ++ I + SLR LD Sbjct: 69 MPDISFLSELRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRLQNISCCP-MASLRHLD 127 Query: 127 LYDNQIKKIE---NLEALTELEILDISFNLLRNIEGVDKLTRLK----KLFLVNNKIS-- 177 L N + LT+L L +S R ++ + + L L LV+ I Sbjct: 128 LSFNDFDVLPVCKEFGNLTKLTFLGLSAAKFRQLD-LLPVAHLHLSCILLDLVSYHIKGG 186 Query: 178 KIENLS-NLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVL 235 + E+L + L N + +++ ++ L L L K+ +T L+ L Sbjct: 187 ETESLQIPNTTVLHLVFHPNSLFSVQVNMSVNALGHLQLSNIKLNDENCQRLMTFLSEL 245 Score = 45.1 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 20/76 (26%), Positives = 39/76 (51%), Gaps = 3/76 (3%) Query: 81 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLI-KCIENLEELQSLRELDLYDNQIKKIEN-- 137 ++L+ + + KVK L L N I +++ LQ+L+EL++ NQ+K + + Sbjct: 433 LNLSSNMLTGSVFRCLPPKVKVLDLHNNRIMSIPKDVTHLQALQELNVASNQLKSVPDGV 492 Query: 138 LEALTELEILDISFNL 153 + LT L+ + + N Sbjct: 493 FDRLTSLQYIWLHDNP 508 >1OGQ-A nrPDB Length = 313 Score = 67.1 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 47/231 (20%), Positives = 93/231 (40%), Gaps = 22/231 (9%) Query: 99 KVKTLCLRQNLIKCIENLEE-LQSLRELDLY-----DNQIKKIEN-LEALTELEILDISF 151 +V L L + + L +L L+ +N + I + LT+L L I+ Sbjct: 51 RVNNLDLSGLNLPKPYPIPSSLANLPYLNFLYIGGINNLVGPIPPAIAKLTQLHYLYITH 110 Query: 152 NLLR--NIEGVDKLTRLKKLFLVNNKISKI--ENLSNLHQLQMLELGSNRIRAIENIDTL 207 + + + ++ L L N +S ++S+L L + NRI D+ Sbjct: 111 TNVSGAIPDFLSQIKTLVTLDFSYNALSGTLPPSISSLPNLVGITFDGNRISG-AIPDSY 169 Query: 208 TNLESLF----LGKNKIT-KLQNLDALTNLTVLSMQSNRL--TKIEGLQNLVNLRELYLS 260 + LF + +N++T K+ A NL + + N L + N ++++L+ Sbjct: 170 GSFSKLFTSMTISRNRLTGKIPPTFANLNLAFVDLSRNMLEGDASVLFGSDKNTQKIHLA 229 Query: 261 HNGIEV-IEGLENNNKLTMLDIASNRI-KKIE-NISHLTELQEFWMNDNLL 308 N + + + + L LD+ +NRI + ++ L L ++ N L Sbjct: 230 KNSLAFDLGKVGLSKNLNGLDLRNNRIYGTLPQGLTQLKFLHSLNVSFNNL 280 Score = 42.1 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 24/129 (18%), Positives = 44/129 (34%), Gaps = 10/129 (7%) Query: 216 GKNKITKLQNLDALTNLTVLS-MQSNRLTKI-----EGLQNLVNLRELYLSHNGIEVI-- 267 G N +L NL L+ + + + + L L LY++H + Sbjct: 59 GLNLPKPYPIPSSLANLPYLNFLYIGGINNLVGPIPPAIAKLTQLHYLYITHTNVSGAIP 118 Query: 268 EGLENNNKLTMLDIASNRIKKI--ENISHLTELQEFWMNDNLLESWSDLDELKGARSLET 325 + L L LD + N + +IS L L + N + ++ + Sbjct: 119 DFLSQIKTLVTLDFSYNALSGTLPPSISSLPNLVGITFDGNRISGAIPDSYGSFSKLFTS 178 Query: 326 VYLERNPLQ 334 + + RN L Sbjct: 179 MTISRNRLT 187 >3T6Q-A nrPDB Length = 606 Score = 66.7 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 66/337 (19%), Positives = 122/337 (36%), Gaps = 55/337 (16%) Query: 67 VDMETINLDRDAEDVDLNHYRIGKIEGFEVLK--KVKTLCLRQNLIK-----CIENLEEL 119 +D ++ + E + L I I+ + K+K L + N I + +L++ Sbjct: 120 IDFIPLHNQKTLESLYLGSNHISSIKLPKGFPTEKLKVLDFQNNAIHYLSKEDMSSLQQA 179 Query: 120 QSLRELDLYDNQIKKIEN----------------------LEALTELEILDISFNLLRNI 157 +L L+L N I IE + L I + ++ Sbjct: 180 TNL-SLNLNGNDIAGIEPGAFDSAVFQSLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDM 238 Query: 158 EGVDKLT---------RLKKLFLVNNKISKI--ENLSNLHQLQMLELGSNRIRAIE-NID 205 + D ++ + L + I LQ L+L + + + + Sbjct: 239 DDEDISPAVFEGLCEMSVESINLQKHYFFNISSNTFHCFSGLQELDLTATHLSELPSGLV 298 Query: 206 TLTNLESLFLGKNKITKLQNLD--ALTNLTVLSMQSNRLTKIE----GLQNLVNLRELYL 259 L+ L+ L L NK L + +LT LS++ N ++E L+NL NLREL L Sbjct: 299 GLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNT-KRLELGTGCLENLENLRELDL 357 Query: 260 SHNGIEVIE----GLENNNKLTMLDIASNRIKKI--ENISHLTELQEFWMNDNLLESWSD 313 SH+ IE + L N + L L+++ N + E +L+ + L+ Sbjct: 358 SHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKDA 417 Query: 314 LDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSV 350 + L+ + L + L + + AL + Sbjct: 418 QSPFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHL 454 Score = 66.7 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 56/266 (21%), Positives = 111/266 (41%), Gaps = 33/266 (12%) Query: 72 INLDRDAEDVDLNHYRIGKIE----GFEVLKKVKTLCLRQN--LIKCIENLEELQSLREL 125 + + ++DL+H I + L +++L L N L E +E L L Sbjct: 346 LENLENLRELDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELL 405 Query: 126 DLYDNQIKKIE---NLEALTELEILDISFNLL--RNIEGVDKLTRLKKLFLVNN-----K 175 DL ++K + + L L++L++S +LL + + D L L+ L L N Sbjct: 406 DLAFTRLKVKDAQSPFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHLNLQGNHFPKGN 465 Query: 176 ISKIENLSNLHQLQMLELGSNRIRAI--ENIDTLTNLESLFLGKNKI--TKLQNLDALTN 231 I K +L L +L++L L + +I +L + + L N++ + ++ L L Sbjct: 466 IQKTNSLQTLGRLEILVLSFCDLSSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKG 525 Query: 232 LTVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKI 289 + L++ SN ++ I L L R + L N ++ + + L+ ++K+ Sbjct: 526 I-YLNLASNHISIILPSLLPILSQQRTINLRQNPLDC-----TCSNIYFLEWYKENMQKL 579 Query: 290 ENI-----SHLTELQEFWMNDNLLES 310 E+ + L+ ++D L Sbjct: 580 EDTEDTLCENPPLLRGVRLSDVTLSC 605 Score = 48.6 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 41/171 (23%), Positives = 65/171 (38%), Gaps = 28/171 (16%) Query: 145 EILDISFNLLRNIE--GVDKLTRLKKLFLVNNKISKI--ENLSNLHQLQMLELGSNRI-- 198 E L+ SFN+L I+ +L L L L +I I + + H+L L L +N + Sbjct: 36 ECLEFSFNVLPTIQNTTFSRLINLTFLDLTRCQIYWIHEDTFQSQHRLDTLVLTANPLIF 95 Query: 199 RAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELY 258 A + L+ LF + I+ + + L N L LY Sbjct: 96 MAETALSGPKALKHLFFIQTGISSIDFI--------------------PLHNQKTLESLY 135 Query: 259 LSHNGIEVIEGLENNN--KLTMLDIASNRIKKIENISHLTELQEFWMNDNL 307 L N I I+ + KL +LD +N I + + Q ++ NL Sbjct: 136 LGSNHISSIKLPKGFPTEKLKVLDFQNNAIHYLSKEDMSSLQQATNLSLNL 186 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 59/364 (16%), Positives = 116/364 (31%), Gaps = 101/364 (27%) Query: 71 TINLDRDAEDVDLNHYRIGKIEGFEVLK-----KVKTLCLRQNLIKCIEN--LEELQSLR 123 T + D+ + ++N + G + + L N++ I+N L +L Sbjct: 1 TTSSDQKCIEKEVNKTYNCENLGLNEIPGTLPNSTECLEFSFNVLPTIQNTTFSRLINLT 60 Query: 124 ELDLYDNQIKKIEN--LEALTELEILDISFNLL-----RNIEGVDKLTRL---------- 166 LDL QI I ++ L+ L ++ N L + G L L Sbjct: 61 FLDLTRCQIYWIHEDTFQSQHRLDTLVLTANPLIFMAETALSGPKALKHLFFIQTGISSI 120 Query: 167 -----------KKLFLVNNKISKIENLSNLH--QLQMLELGSNRIRAIENIDTLTNLE-- 211 + L+L +N IS I+ +L++L+ +N I + + +++L+ Sbjct: 121 DFIPLHNQKTLESLYLGSNHISSIKLPKGFPTEKLKVLDFQNNAIHYLSK-EDMSSLQQA 179 Query: 212 ---SLFLGKNKITKLQN----------------------LDALTNLTVLSMQSNRLTKIE 246 SL L N I ++ L N T+ S+ ++ Sbjct: 180 TNLSLNLNGNDIAGIEPGAFDSAVFQSLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDMD 239 Query: 247 G---------------------------------LQNLVNLRELYLSHNGIEVIE-GLEN 272 L+EL L+ + + GL Sbjct: 240 DEDISPAVFEGLCEMSVESINLQKHYFFNISSNTFHCFSGLQELDLTATHLSELPSGLVG 299 Query: 273 NNKLTMLDIASNRIKKIENISH--LTELQEFWMNDNLLESWSDLDELKGARSLETVYLER 330 + L L +++N+ + + IS L + N L+ +L + L Sbjct: 300 LSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTKRLELGTGCLENLENLRELDLSH 359 Query: 331 NPLQ 334 + ++ Sbjct: 360 DDIE 363 >2Z7X-A nrPDB Length = 549 Score = 65.9 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 44/180 (24%), Positives = 76/180 (42%), Gaps = 15/180 (8%) Query: 139 EALTELEILDISFNL-----LRNIEGVDKLTRLKKLFLVNNKISKIEN----LSNLHQLQ 189 + L LE LD+S NL L+N D L+ L L N ++ +E L L L Sbjct: 331 QHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLT 390 Query: 190 MLELGSNRIRAIE-NIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGL 248 +++ N ++ ++ L L +I + L +L + +N L Sbjct: 391 NIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIP-KTLEILDVSNNNLNLFSLN 449 Query: 249 QNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIEN--ISHLTELQEFWMNDN 306 L+ELY+S N + + L +L I+ N++K + + LT LQ+ W++ N Sbjct: 450 LP--QLKELYISRNKLMTLPDASLLPMLLVLKISRNQLKSVPDGIFDRLTSLQKIWLHTN 507 Score = 62.5 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 49/192 (25%), Positives = 89/192 (46%), Gaps = 18/192 (9%) Query: 98 KKVKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQIKKIE--NLEALTELEILDISFNL 153 + VK+L L N I I N L+ +L+ L L N I IE + +L LE LD+S+N Sbjct: 26 EAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNY 85 Query: 154 LRNIEG--VDKLTRLKKLFLVNNKISKIEN---LSNLHQLQMLELGS----NRIRAIENI 204 L N+ L+ L L L+ N + S+L +LQ+L +G+ +I+ ++ Sbjct: 86 LSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQR-KDF 144 Query: 205 DTLTNLESLFLGKNKITKLQN--LDALTNLTVLSMQSNR-LTKIEGLQNLV-NLRELYLS 260 LT LE L + + + + L ++ N++ L + + + +E ++ ++ L L Sbjct: 145 AGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELR 204 Query: 261 HNGIEVIEGLEN 272 ++ E Sbjct: 205 DTDLDTFHFSEL 216 Score = 45.1 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 57/291 (19%), Positives = 109/291 (37%), Gaps = 27/291 (9%) Query: 64 ELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKC------IENLE 117 E+ VD+ + + D DL+ + ++ E +K R I ++ L Sbjct: 189 EIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLN 248 Query: 118 ELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKIS 177 ++ L EL+ D + + N A ++D I + + R + +S Sbjct: 249 QISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRL-HIPRFYLFY----DLS 303 Query: 178 KIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKN-----KITKLQNLDALTNL 232 + +L+ + +E + L +LE L L +N + DA +L Sbjct: 304 TLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSL 363 Query: 233 TVLSMQSNRLTKIE----GLQNLVNLRELYLSHNGIEVIE-GLENNNKLTMLDIASNRIK 287 L ++ N L +E L L NL + +S N + + K+ L+++S RI Sbjct: 364 QTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIH 423 Query: 288 KIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQ 338 + L+ +++N L +S L+ +Y+ RN L P Sbjct: 424 SVTGC-IPKTLEILDVSNNNLNLFSLNLP-----QLKELYISRNKLMTLPD 468 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 51/328 (15%), Positives = 98/328 (29%), Gaps = 66/328 (20%) Query: 77 DAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDL----YDNQI 132 + D+ N+ F+ L + L L N K + L +L + + Sbjct: 77 EHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTF 136 Query: 133 KKIE--NLEALTELEILDISFNLLRN--IEGVDKLTRLKKLFLVNNK-------ISKIEN 181 KI+ + LT LE L+I + L++ + + + + L L + + + Sbjct: 137 TKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTS 196 Query: 182 LSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLS----- 236 +L+ +L + + +T + ++ KIT + L +S Sbjct: 197 SVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLEL 256 Query: 237 --------------MQSN--------------RLTKIEGLQNLVNLRELYL--------- 259 N R I +L LY Sbjct: 257 EFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRIT 316 Query: 260 ---SHNGIEVIEGLENNNKLTMLDIASN-----RIKKIENISHLTELQEFWMNDNLLESW 311 S + ++ L LD++ N +K LQ + N L S Sbjct: 317 VENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASL 376 Query: 312 SDLDE-LKGARSLETVYLERNPLQKDPQ 338 E L ++L + + +N P+ Sbjct: 377 EKTGETLLTLKNLTNIDISKNSFHSMPE 404 Score = 37.1 bits (84), Expect = 0.012, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 28/58 (48%), Gaps = 2/58 (3%) Query: 98 KKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIEN--LEALTELEILDISFNL 153 ++K L + +N + + + L L L + NQ+K + + + LT L+ + + N Sbjct: 451 PQLKELYISRNKLMTLPDASLLPMLLVLKISRNQLKSVPDGIFDRLTSLQKIWLHTNP 508 >3CVR-A nrPDB Length = 571 Score = 65.6 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 39/186 (20%), Positives = 81/186 (43%), Gaps = 12/186 (6%) Query: 168 KLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLD 227 +L L +S + + Q+ +LE+ N + ++ + +LE L N+++ L L Sbjct: 63 ELQLNRLNLSSLPDNLP-PQITVLEITQNALISLP--ELPASLEYLDACDNRLSTLPELP 119 Query: 228 ALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIK 287 A +L L + +N+LT + L L L + +N + ++ E L +L + +N++ Sbjct: 120 A--SLKHLDVDNNQLTMLPELPAL--LEYINADNNQLTMLP--ELPTSLEVLSVRNNQLT 173 Query: 288 KIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLAL 347 + + L+ ++ NLLES + ++ S ET R + ++ Sbjct: 174 FLPELPE--SLEALDVSTNLLESLPAV-PVRNHHSEETEIFFRCRENRITHIPENILSLD 230 Query: 348 PSVRQI 353 P+ I Sbjct: 231 PTCTII 236 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 34/161 (21%), Positives = 71/161 (44%), Gaps = 16/161 (9%) Query: 91 IEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDIS 150 I E+ ++ L N + + L SL+ LD+ +NQ+ + L AL LE ++ Sbjct: 93 ISLPELPASLEYLDACDNRLSTLPELPA--SLKHLDVDNNQLTMLPELPAL--LEYINAD 148 Query: 151 FNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNL 210 N L + + T L+ L + NN+++ + L L+ L++ +N + ++ + + Sbjct: 149 NNQLTMLP--ELPTSLEVLSVRNNQLTFLPELPE--SLEALDVSTNLLESLPAVPVRNHH 204 Query: 211 ES-----LFLGKNKITKLQN--LDALTNLTVLSMQSNRLTK 244 +N+IT + L T++ ++ N L+ Sbjct: 205 SEETEIFFRCRENRITHIPENILSLDPTCTII-LEDNPLSS 244 >3RG1-A nrPDB Length = 612 Score = 65.6 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 62/297 (20%), Positives = 118/297 (39%), Gaps = 55/297 (18%) Query: 41 ADLSEQSLKDGEERGEEDPEEEH--ELPVDMETINLDRDAEDVDLNHYRIGKIEGF--EV 96 +DLS + + E D H LP +E +N + + LN ++ Sbjct: 266 SDLSSSTFRCFTRVQELDLTAAHLNGLPSGIEGMNSLK---KLVLNANSFDQLCQINAAS 322 Query: 97 LKKVKTLCLRQNLIK---CIENLEELQSLRELDLYDNQIKKIE----NLEALTELEILDI 149 ++ L ++ N+ K LE+L++L++LDL + I+ + L+ L L+ L++ Sbjct: 323 FPSLRDLYIKGNMRKLDLGTRCLEKLENLQKLDLSHSDIEASDCCNLQLKNLRHLQYLNL 382 Query: 150 SFN--------------LLRNIE-------------GVDKLTRLKKLFLVNNKISKIEN- 181 S+N L ++ L L+ L L + + Sbjct: 383 SYNEPLGLEDQAFKECPQLELLDVAFTHLHVKAPHSPFQNLHLLRVLNLSHCLLDTSNQH 442 Query: 182 -LSNLHQLQMLELGSNR-----IRAIENIDTLTNLESLFLGKNKITKL--QNLDALTNLT 233 L+ L L+ L L N I + + +LE L L + + Q L N+ Sbjct: 443 LLAGLQDLRHLNLQGNSFQDGSISKTNLLQMVGSLEILILSSCNLLSIDQQAFHGLRNVN 502 Query: 234 VLSMQSNRLTKIEGLQNLVNLRELYLS--HNGIEVIEG--LENNNKLTMLDIASNRI 286 L + N LT + + L +L+ LYL+ N I +I L ++ ++++++ N + Sbjct: 503 HLDLSHNSLTG-DSMDALSHLKGLYLNMASNNIRIIPPHLLPALSQQSIINLSHNPL 558 Score = 64.8 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 58/308 (18%), Positives = 113/308 (36%), Gaps = 53/308 (17%) Query: 75 DRDAEDVDLNHYRIGKIEGFEVLK--KVKTLCLRQNLIKCIE-----NLEELQSLRELDL 127 + E + L I I E +K L + N I I +LE+ +L L+ Sbjct: 127 LENLESLHLGSNHISSINLPENFPTQNLKVLDFQNNAIHYISRKDTNSLEQATNL-SLNF 185 Query: 128 YDNQIKKIEN-------LEALTE-----------------LEILDISFNLLRNIEGVDKL 163 N IK IE ++L L+ L + + + + Sbjct: 186 NGNDIKGIEPGAFISKIFQSLKFGGSLNLFIIFKGLQNSTLQSLWLGTFEDTDDQYLTSA 245 Query: 164 T-------RLKKLFLVNNKISKIE--NLSNLHQLQMLELGSNRIRAIE-NIDTLTNLESL 213 T ++ + L ++ S + ++Q L+L + + + I+ + +L+ L Sbjct: 246 TFEGLCDMSVESINLQKHRFSDLSSSTFRCFTRVQELDLTAAHLNGLPSGIEGMNSLKKL 305 Query: 214 FLGKNKITKLQNLDA--LTNLTVLSMQSNRLTK---IEGLQNLVNLRELYLSHNGIEVIE 268 L N +L ++A +L L ++ N L+ L NL++L LSH+ IE + Sbjct: 306 VLNANSFDQLCQINAASFPSLRDLYIKGNMRKLDLGTRCLEKLENLQKLDLSHSDIEASD 365 Query: 269 ----GLENNNKLTMLDIASNRIKKIENIS--HLTELQEFWMNDNLLESWSDLDELKGARS 322 L+N L L+++ N +E+ + +L+ + L + + Sbjct: 366 CCNLQLKNLRHLQYLNLSYNEPLGLEDQAFKECPQLELLDVAFTHLHVKAPHSPFQNLHL 425 Query: 323 LETVYLER 330 L + L Sbjct: 426 LRVLNLSH 433 Score = 50.9 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 45/166 (27%), Positives = 69/166 (41%), Gaps = 16/166 (9%) Query: 97 LKKVKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQIKKIEN--LEALTELEILDISFN 152 + L N + I+N L +L LDL QI + ++ +L + ++ N Sbjct: 31 PNTTEVLEFSFNFLPTIQNTTFSRLINLIFLDLTRCQINWVHEDTFQSHHQLNTIVLTGN 90 Query: 153 LLRNIE--GVDKLTRLKKLFLVNNKISKIE--NLSNLHQLQMLELGSNRIRAIENIDTLT 208 L + + LK LFL IS +E + NL L+ L LGSN I +I + Sbjct: 91 PLIFMAETSLTGPKFLKHLFLTQTGISNLEFIPVHNLENLESLHLGSNHISSINLPENFP 150 Query: 209 --NLESLFLGKNKI-----TKLQNLDALTNLTVLSMQSNRLTKIEG 247 NL+ L N I +L+ TNL+ L+ N + IE Sbjct: 151 TQNLKVLDFQNNAIHYISRKDTNSLEQATNLS-LNFNGNDIKGIEP 195 Score = 49.0 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 38/158 (24%), Positives = 60/158 (37%), Gaps = 11/158 (6%) Query: 160 VDKLTRLKK-LFLVNNKISKIEN--LSNLHQLQMLELGSNRI--RAIENIDTLTNLESLF 214 D L + L N + I+N S L L L+L +I + + L ++ Sbjct: 27 PDTLPNTTEVLEFSFNFLPTIQNTTFSRLINLIFLDLTRCQINWVHEDTFQSHHQLNTIV 86 Query: 215 LGKNKITKLQN--LDALTNLTVLSMQSNRLTKIEGLQ--NLVNLRELYLSHNGIEVIEGL 270 L N + + L L L + ++ +E + NL NL L+L N I I Sbjct: 87 LTGNPLIFMAETSLTGPKFLKHLFLTQTGISNLEFIPVHNLENLESLHLGSNHISSINLP 146 Query: 271 ENNN--KLTMLDIASNRIKKIENISHLTELQEFWMNDN 306 EN L +LD +N I I + Q ++ N Sbjct: 147 ENFPTQNLKVLDFQNNAIHYISRKDTNSLEQATNLSLN 184 >4ECN-A nrPDB Length = 876 Score = 63.6 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 56/319 (17%), Positives = 117/319 (36%), Gaps = 49/319 (15%) Query: 57 EDPEEEHELPVDMETIN--LDRDAEDVDL-NHYRIGKIEGFEV-LKKVKTLCLRQNLIKC 112 ED ++ + E ++ +D DV+L N + ++ F L ++++L + N Sbjct: 470 EDANSDYAKQYENEELSWSNLKDLTDVELYNCPNMTQLPDFLYDLPELQSLNIACNRGIS 529 Query: 113 IENLEE-----------LQSLRELDLYDNQIKKIE---NLEALTELEILDISFNLLRNIE 158 L+ ++ + N +++ +L+ + +L +LD N +R++E Sbjct: 530 AAQLKADWTRLADDEDTGPKIQIFYMGYNNLEEFPASASLQKMVKLGLLDCVHNKVRHLE 589 Query: 159 GVDKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRIRAIENIDTLTN---LESL 213 +L L L N+I +I + Q++ L N+++ I NI + + S+ Sbjct: 590 AFGTNVKLTDLKLDYNQIEEIPEDFCAFTDQVEGLGFSHNKLKYIPNIFNAKSVYVMGSV 649 Query: 214 FLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEG--LE 271 NKI S N ++ + + N + LS+N I+ Sbjct: 650 DFSYNKIG--------------SEGRNISCSMDDYKGI-NASTVTLSYNEIQKFPTELFA 694 Query: 272 NNNKLTMLDIASNRIKKIENISHLTE---------LQEFWMNDNLLESWSDLDELKGARS 322 + ++ + +++N + I S + L + N L S SD Sbjct: 695 TGSPISTIILSNNLMTSIPENSLKPKDGNYKNTYLLTTIDLRFNKLTSLSDDFRATTLPY 754 Query: 323 LETVYLERNPLQKDPQYRR 341 L + + N P Sbjct: 755 LSNMDVSYNCFSSFPTQPL 773 >2Z7X-B nrPDB Length = 520 Score = 62.1 bits (149), Expect = 3e-10, Method: Composition-based stats. Identities = 37/134 (27%), Positives = 69/134 (51%), Gaps = 10/134 (7%) Query: 96 VLKKVKTLCLRQNLIKCIENL----EELQSLRELDLYDNQIKKIENLEA---LTELEILD 148 L +++TL L+ N +K + + +++SL++LD+ N + E L L+ Sbjct: 346 HLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLN 405 Query: 149 ISFNLLRNIEGVDKLTRLKKLFLVNNKISKIEN-LSNLHQLQMLELGSNRIRAIEN--ID 205 +S N+L + R+K L L +NKI I + L LQ L + SN+++++ + D Sbjct: 406 MSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVASNQLKSVPDGIFD 465 Query: 206 TLTNLESLFLGKNK 219 LT+L+ ++L N Sbjct: 466 RLTSLQKIWLHTNP 479 Score = 61.3 bits (147), Expect = 6e-10, Method: Composition-based stats. Identities = 49/297 (16%), Positives = 103/297 (34%), Gaps = 39/297 (13%) Query: 72 INLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQ 131 ++ + + + Y + + + K+ L L N+ + + L Sbjct: 194 LSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTL-NNIETTWNSFIRILQLVWHTTVWYF 252 Query: 132 IKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQML 191 L+ + D S L+ + ++ + + I +I + N+ Sbjct: 253 SISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDV--FGFPQSYIYEIFSNMNIKNFT-- 308 Query: 192 ELGSNRIRAIENIDTLTNLESLFLGKNKITK--LQNLDALTNLTVLSMQSNRLTKIEGLQ 249 + R+ + ++ L N +T +N LT L L +Q N+L ++ + Sbjct: 309 -VSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIA 367 Query: 250 NLV----NLRELYLSHNG------------------IEVIEGLE-------NNNKLTMLD 280 + +L++L +S N + + + ++ +LD Sbjct: 368 EMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLD 427 Query: 281 IASNRIKKIE-NISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKD 336 + SN+IK I + L LQE + N L+S D SL+ ++L NP Sbjct: 428 LHSNKIKSIPKQVVKLEALQELNVASNQLKSVPD-GIFDRLTSLQKIWLHTNPWDCS 483 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 29/130 (22%), Positives = 57/130 (43%), Gaps = 6/130 (4%) Query: 216 GKNKITKLQNLDALTNLTVLSMQSNRLTKI--EGLQNLVNLRELYLSHNGIE--VIEGLE 271 KN + + D T+L++ N ++++ + +L LR L +SHN I+ I + Sbjct: 8 SKNGLIHVPK-DLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFK 66 Query: 272 NNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERN 331 N +L LD++ N++ KI + L+ ++ N ++ E L+ + L Sbjct: 67 FNQELEYLDLSHNKLVKISCHPTV-NLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTT 125 Query: 332 PLQKDPQYRR 341 L+K Sbjct: 126 HLEKSSVLPI 135 Score = 42.1 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 47/290 (16%), Positives = 110/290 (37%), Gaps = 39/290 (13%) Query: 81 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIE---N 137 + N + I F+ ++++ L L N + I + +L+ LDL N + Sbjct: 52 ISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTV-NLKHLDLSFNAFDALPICKE 110 Query: 138 LEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNR 197 +++L+ L +S L V + L ISK+ L L Sbjct: 111 FGNMSQLKFLGLSTTHLEK-SSVLPIAHL--------NISKV-----LLVLGETYGEKED 156 Query: 198 IRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLREL 257 +++ +T ESL + + + ++ TV +++ + + + L + Sbjct: 157 PEGLQDFNT----ESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCV--------LEDN 204 Query: 258 YLSHNGIEVIEGLENNNKLTMLDIAS-----NRIKKIENISHLTELQEFWMNDNLLESWS 312 S+ + ++ L+ N KL+ L + + N +I + T + F +++ L+ Sbjct: 205 KCSY-FLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQL 263 Query: 313 DLDELK-GARSLETVYLER--NPLQKDPQYRRKVMLALPSVRQIDATFVR 359 D + SL+ + + + + + PQ + + +++ + R Sbjct: 264 DFRDFDYSGTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTR 313 >4AY9-X nrPDB Length = 350 Score = 59.8 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 46/208 (22%), Positives = 82/208 (39%), Gaps = 20/208 (9%) Query: 115 NLEELQSLRELDLYDNQ-IKKIEN--LEALTELEILDI--SFNLLR-NIEGVDKLTRLKK 168 L ++++ N ++ IE L +L + I + NLL N E L L+ Sbjct: 49 AFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQY 108 Query: 169 LFLVNNKISKIENLSNLHQLQMLELG-----SNRIRAIENIDTLT-NLESLFLGKNKITK 222 L + N I + ++ +H LQ + L + + L+ L+L KN I + Sbjct: 109 LLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQE 168 Query: 223 L-QNLDALTNLTVLSM-QSNRLTKIEG--LQNLVNLRELYLSHNGIEVIE--GLENNNKL 276 + + T L L++ +N L ++ L +S I + GLEN KL Sbjct: 169 IHNSAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKL 228 Query: 277 TMLDIASNRIKKIENISHLTELQEFWMN 304 ++ +KK+ + L L E + Sbjct: 229 RA--RSTYNLKKLPTLEKLVALMEASLT 254 Score = 55.9 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 42/165 (25%), Positives = 76/165 (46%), Gaps = 12/165 (7%) Query: 84 NHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRE--LDLYDN-QIKKIE--NL 138 N+ E F+ L ++ L + IK + ++ ++ SL++ LD+ DN I IE + Sbjct: 90 NNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSF 149 Query: 139 EALT-ELEILDISFNLLRNIE-GVDKLTRLKKLFLV-NNKISKIEN--LSNLHQLQMLEL 193 L+ E IL ++ N ++ I T+L +L L NN + ++ N +L++ Sbjct: 150 VGLSFESVILWLNKNGIQEIHNSAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDI 209 Query: 194 GSNRIRAIENIDTLTNLESLFL-GKNKITKLQNLDALTNLTVLSM 237 RI ++ + L NL+ L + KL L+ L L S+ Sbjct: 210 SRTRIHSLPSY-GLENLKKLRARSTYNLKKLPTLEKLVALMEASL 253 Score = 52.9 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 39/202 (19%), Positives = 78/202 (38%), Gaps = 15/202 (7%) Query: 161 DKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRIRAI---ENIDTLTNLESLFL 215 D +L V K+ I+ S L+ +E+ N + + + L L + + Sbjct: 27 DLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRI 86 Query: 216 GK-NKITKLQN--LDALTNLTVLSMQSNRLTKIEGLQNLVNLRE--LYLSHN----GIEV 266 K N + + L NL L + + + + + + +L++ L + N IE Sbjct: 87 EKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIER 146 Query: 267 IEGLENNNKLTMLDIASNRIKKIENISHL-TELQEFWMNDNLLESWSDLDELKGARSLET 325 + + + +L + N I++I N + T+L E ++DN D GA Sbjct: 147 NSFVGLSFESVILWLNKNGIQEIHNSAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVI 206 Query: 326 VYLERNPLQKDPQYRRKVMLAL 347 + + R + P Y + + L Sbjct: 207 LDISRTRIHSLPSYGLENLKKL 228 >5Y31-B nrPDB Length = 544 Score = 57.9 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 31/125 (24%), Positives = 49/125 (39%), Gaps = 11/125 (8%) Query: 150 SFNLL-RNIEGVDK--LTRLKKLFLVNNKISKIENLSNL--HQLQMLELGSNRIRAI--E 202 N L N + + + L V + ++I S L LQ+L SN I + Sbjct: 30 KDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDD 89 Query: 203 NIDTLTNLESLFLGKNKITKLQ--NLDALTNLTVLSMQSNRLTKIEG--LQNLVNLRELY 258 L +LE LF+ N I + L +L LS+ +N L + + L +L + Sbjct: 90 AFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVD 149 Query: 259 LSHNG 263 L N Sbjct: 150 LRGNS 154 Score = 55.5 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 22/109 (20%), Positives = 35/109 (32%), Gaps = 8/109 (7%) Query: 77 DAEDVDLNHYRIGKIEGFEVL--KKVKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQI 132 D + +I L ++ L N I + L L L + +N I Sbjct: 48 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI 107 Query: 133 KKI--ENLEALTELEILDISFNLLRNIEG--VDKLTRLKKLFLVNNKIS 177 K I L L L ++ N L+ + L L + L N + Sbjct: 108 KSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFN 156 >1XWD-C nrPDB Length = 252 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 47/204 (23%), Positives = 81/204 (39%), Gaps = 20/204 (9%) Query: 115 NLEELQSLRELDLYDNQ-IKKIEN--LEALTELEILDI--SFNLLR-NIEGVDKLTRLKK 168 L ++++ N ++ IE L +L + I + NLL N E L L+ Sbjct: 49 AFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQY 108 Query: 169 LFLVNNKISKIENLSNLHQLQMLELG-----SNRIRAIENIDTLT-NLESLFLGKNKITK 222 L + N I + ++ +H LQ + L + + L+ L+L KN I + Sbjct: 109 LLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQE 168 Query: 223 LQN-LDALTNLTVLSM-QSNRLTKIEG--LQNLVNLRELYLSHNGIEVIE--GLENNNKL 276 + N T L L++ +N L ++ L +S I + GLEN KL Sbjct: 169 IHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKL 228 Query: 277 TMLDIASNRIKKIENISHLTELQE 300 ++ +KK+ + L L E Sbjct: 229 RA--RSTYNLKKLPTLEKLVALME 250 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 41/160 (25%), Positives = 74/160 (46%), Gaps = 12/160 (7%) Query: 84 NHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRE--LDLYDN-QIKKIE--NL 138 N+ E F+ L ++ L + IK + ++ ++ SL++ LD+ DN I IE + Sbjct: 90 NNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSF 149 Query: 139 EALT-ELEILDISFNLLRNIEG-VDKLTRLKKLFLV-NNKISKIEN--LSNLHQLQMLEL 193 L+ E IL ++ N ++ I T+L +L L NN + ++ N +L++ Sbjct: 150 VGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDI 209 Query: 194 GSNRIRAIENIDTLTNLESLFL-GKNKITKLQNLDALTNL 232 RI ++ + L NL+ L + KL L+ L L Sbjct: 210 SRTRIHSLPSY-GLENLKKLRARSTYNLKKLPTLEKLVAL 248 Score = 49.4 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 39/202 (19%), Positives = 78/202 (38%), Gaps = 15/202 (7%) Query: 161 DKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRIRAI---ENIDTLTNLESLFL 215 D +L V K+ I+ S L+ +E+ N + + + L L + + Sbjct: 27 DLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRI 86 Query: 216 GK-NKITKLQN--LDALTNLTVLSMQSNRLTKIEGLQNLVNLRE--LYLSHN----GIEV 266 K N + + L NL L + + + + + + +L++ L + N IE Sbjct: 87 EKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIER 146 Query: 267 IEGLENNNKLTMLDIASNRIKKIENISHL-TELQEFWMNDNLLESWSDLDELKGARSLET 325 + + + +L + N I++I N + T+L E ++DN D GA Sbjct: 147 NSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVI 206 Query: 326 VYLERNPLQKDPQYRRKVMLAL 347 + + R + P Y + + L Sbjct: 207 LDISRTRIHSLPSYGLENLKKL 228 >5LJ5-W nrPDB Length = 238 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 29/128 (22%), Positives = 56/128 (43%), Gaps = 10/128 (7%) Query: 100 VKTLCLRQNLIKCIENLEELQSLRE-LDLYDNQIKKIENLEALTELEILDISFNLLRNIE 158 ++ L L + +L+ L LDL +N + I +L ++ L + N + ++ Sbjct: 31 LRDLQLETDSESMPSSLKHLTKPTHILDLTNNDLIMIPDLSRRDDIHTLLLGRNNIVEVD 90 Query: 159 GVDKLTRLKKLFLVNNKISKIENLSNLHQ----LQMLELGSNRIRAIEN-----IDTLTN 209 G ++ L L NN I + E+L L + L+ L L N++ + N + + + Sbjct: 91 GRLLPMNVQNLTLSNNSIRRFEDLQRLRRAPRTLKNLTLIGNQVCHLANYREHVLRLVPH 150 Query: 210 LESLFLGK 217 LE+L Sbjct: 151 LETLDFQN 158 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 25/141 (17%), Positives = 60/141 (42%), Gaps = 11/141 (7%) Query: 174 NKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLT 233 N ++ L LQ+ + +++++ T++ L L N + + +L ++ Sbjct: 20 NGKYNVDKCVILRDLQLETDSESMPSSLKHLTKPTHI--LDLTNNDLIMIPDLSRRDDIH 77 Query: 234 VLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNK----LTMLDIASNRIKKI 289 L + N + +++G +N++ L LS+N I E L+ + L L + N++ + Sbjct: 78 TLLLGRNNIVEVDGRLLPMNVQNLTLSNNSIRRFEDLQRLRRAPRTLKNLTLIGNQVCHL 137 Query: 290 EN-----ISHLTELQEFWMND 305 N + + L+ + Sbjct: 138 ANYREHVLRLVPHLETLDFQN 158 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 38/197 (19%), Positives = 73/197 (37%), Gaps = 14/197 (7%) Query: 144 LEILDISFNLLRNIEGVDKLTRLK-KLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIE 202 L L + + + LT+ L L NN + I +LS + L LG N I ++ Sbjct: 31 LRDLQLETDSESMPSSLKHLTKPTHILDLTNNDLIMIPDLSRRDDIHTLLLGRNNIVEVD 90 Query: 203 NIDTLTNLESLFLGKNKITKLQNLDALTN----LTVLSMQSNRLTKIEGL--------QN 250 N+++L L N I + ++L L L L++ N++ + + Sbjct: 91 GRLLPMNVQNLTLSNNSIRRFEDLQRLRRAPRTLKNLTLIGNQVCHLANYREHVLRLVPH 150 Query: 251 LVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLES 310 L L ++ + L + I+ + E+ ++ +E Sbjct: 151 LETLDFQNVTAEERKSAMSFPRQADGDTLGPVNTAIRDNGSRDKTMEIMNLVVSKMTVER 210 Query: 311 WSDLDE-LKGARSLETV 326 ++L + L A SLE + Sbjct: 211 RNELKKQLAEATSLEEI 227 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 25/124 (20%), Positives = 53/124 (42%), Gaps = 14/124 (11%) Query: 64 ELPVDMETI-----NLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEE 118 +L D E++ +L + +DL + + I + TL L +N I ++ Sbjct: 35 QLETDSESMPSSLKHLTKPTHILDLTNNDLIMIPDLSRRDDIHTLLLGRNNIVEVDGRLL 94 Query: 119 LQSLRELDLYDNQIKKIENLEALTE----LEILDISFNLLRNI-----EGVDKLTRLKKL 169 +++ L L +N I++ E+L+ L L+ L + N + ++ + + L+ L Sbjct: 95 PMNVQNLTLSNNSIRRFEDLQRLRRAPRTLKNLTLIGNQVCHLANYREHVLRLVPHLETL 154 Query: 170 FLVN 173 N Sbjct: 155 DFQN 158 Score = 36.7 bits (83), Expect = 0.016, Method: Composition-based stats. Identities = 27/132 (20%), Positives = 54/132 (40%), Gaps = 24/132 (18%) Query: 247 GLQNLVNLRELYLSHNGIEVIEGLENNNKLT-MLDIASNRIKKIENIS------------ 293 + V LR+L L + + L++ K T +LD+ +N + I ++S Sbjct: 24 NVDKCVILRDLQLETDSESMPSSLKHLTKPTHILDLTNNDLIMIPDLSRRDDIHTLLLGR 83 Query: 294 ----------HLTELQEFWMNDNLLESWSDLDEL-KGARSLETVYLERNPLQKDPQYRRK 342 +Q +++N + + DL L + R+L+ + L N + YR Sbjct: 84 NNIVEVDGRLLPMNVQNLTLSNNSIRRFEDLQRLRRAPRTLKNLTLIGNQVCHLANYREH 143 Query: 343 VMLALPSVRQID 354 V+ +P + +D Sbjct: 144 VLRLVPHLETLD 155 >4WYK-A nrPDB Length = 461 Score = 47.8 bits (112), Expect = 7e-06, Method: Composition-based stats. Identities = 23/93 (24%), Positives = 51/93 (54%), Gaps = 9/93 (9%) Query: 271 ENNNKLTMLDIASNRIKKIENISHL----TELQEFWMNDNLLESWSDLDELKGARSLETV 326 EN +L L++++NR+ +++++S + L+ ++ N L+S +LD++KG + LE + Sbjct: 168 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLK-LEEL 226 Query: 327 YLERNPL----QKDPQYRRKVMLALPSVRQIDA 355 +L+ N L + Y + P + ++D Sbjct: 227 WLDGNSLCDTFRDQSTYISAIRERFPKLLRLDG 259 Score = 42.5 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 28/125 (22%), Positives = 55/125 (44%), Gaps = 18/125 (14%) Query: 117 EELQSLRELDLYDNQIKKIENLEALT----ELEILDISFNLLRNIEGVDKLTRLK--KLF 170 E + L L+L +N++ +++++ ++ L+IL++S N L++ +DK+ LK +L+ Sbjct: 168 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELW 227 Query: 171 LVNNKISKI------------ENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKN 218 L N + E L +L EL +E TL + + G Sbjct: 228 LDGNSLCDTFRDQSTYISAIRERFPKLLRLDGHELPPPIAFDVEAPTTLPPCKGSYFGTE 287 Query: 219 KITKL 223 + L Sbjct: 288 NLKSL 292 >2IFG-A nrPDB Length = 347 Score = 47.5 bits (111), Expect = 9e-06, Method: Composition-based stats. Identities = 30/138 (21%), Positives = 47/138 (34%), Gaps = 13/138 (9%) Query: 106 RQNLIKCIENLEELQSLREL------DLYDNQIKKIENLEALTELEILDISFNLLRNIEG 159 R + + +L ++L EL L +++ + L L L I+ S + Sbjct: 17 RDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVK-SGLRFVAPDA 75 Query: 160 VDKLTRLKKLFLVNNKISKIE-NLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKN 218 RL +L L N + + LQ L L N + + L E LG Sbjct: 76 FHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGV 135 Query: 219 KITKLQ-----NLDALTN 231 KLQ L + N Sbjct: 136 PEQKLQCHGQGPLAHMPN 153 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 27/101 (26%), Positives = 40/101 (39%), Gaps = 9/101 (8%) Query: 242 LTKIEGLQNLVNLRELY------LSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHL 295 L + L NL ELY L H + + GL LT++ + R + Sbjct: 21 LDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVK-SGLRFVAPDAFHFT 79 Query: 296 TELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKD 336 L ++ N LES S ++G SL+ + L NPL Sbjct: 80 PRLSRLNLSFNALESLS-WKTVQGL-SLQELVLSGNPLHCS 118 >1KOH-A nrPDB Length = 277 Score = 44.8 bits (104), Expect = 6e-05, Method: Composition-based stats. Identities = 23/93 (24%), Positives = 51/93 (54%), Gaps = 9/93 (9%) Query: 271 ENNNKLTMLDIASNRIKKIENISHL----TELQEFWMNDNLLESWSDLDELKGARSLETV 326 EN +L L++++NR+ +++++S + L+ ++ N L+S +LD++KG + LE + Sbjct: 167 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLK-LEEL 225 Query: 327 YLERNPL----QKDPQYRRKVMLALPSVRQIDA 355 +L+ N L + Y + P + ++D Sbjct: 226 WLDGNSLSDTFRDQSTYISAIRERFPKLLRLDG 258 Score = 44.4 bits (103), Expect = 9e-05, Method: Composition-based stats. Identities = 16/68 (23%), Positives = 37/68 (54%), Gaps = 6/68 (8%) Query: 161 DKLTRLKKLFLVNNKISKIENLSNL----HQLQMLELGSNRIRAIENIDTLT--NLESLF 214 + + L L L NN++ +++++S++ L++L L N +++ +D + LE L+ Sbjct: 167 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELW 226 Query: 215 LGKNKITK 222 L N ++ Sbjct: 227 LDGNSLSD 234 Score = 37.8 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 15/68 (22%), Positives = 35/68 (51%), Gaps = 6/68 (8%) Query: 95 EVLKKVKTLCLRQNLIKCIENLEEL----QSLRELDLYDNQIKKIENLEALT--ELEILD 148 E + ++ +L L N + ++++ + +L+ L+L N++K L+ + +LE L Sbjct: 167 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELW 226 Query: 149 ISFNLLRN 156 + N L + Sbjct: 227 LDGNSLSD 234 Score = 37.1 bits (84), Expect = 0.011, Method: Composition-based stats. Identities = 19/68 (27%), Positives = 30/68 (44%), Gaps = 6/68 (8%) Query: 139 EALTELEILDISFNLLRNIEG----VDKLTRLKKLFLVNNKISKIENLSNLH--QLQMLE 192 E + EL L++S N L ++ V K LK L L N++ L + +L+ L Sbjct: 167 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELW 226 Query: 193 LGSNRIRA 200 L N + Sbjct: 227 LDGNSLSD 234 Score = 35.9 bits (81), Expect = 0.030, Method: Composition-based stats. Identities = 15/67 (22%), Positives = 34/67 (50%), Gaps = 6/67 (8%) Query: 249 QNLVNLRELYLSHNGIEVIEGLENN----NKLTMLDIASNRIKKIENISHLT--ELQEFW 302 +N+ L L LS+N + ++ + + L +L+++ N +K + + +L+E W Sbjct: 167 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELW 226 Query: 303 MNDNLLE 309 ++ N L Sbjct: 227 LDGNSLS 233 Score = 28.2 bits (61), Expect = 5.6, Method: Composition-based stats. Identities = 13/64 (20%), Positives = 31/64 (48%), Gaps = 6/64 (9%) Query: 77 DAEDVDLNHYRIGKIEGFEVL----KKVKTLCLRQNLIKCIENLEELQSLR--ELDLYDN 130 + ++L++ R+ +++ + +K L L N +K L++++ L+ EL L N Sbjct: 171 ELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELWLDGN 230 Query: 131 QIKK 134 + Sbjct: 231 SLSD 234 >6J5T-G nrPDB Length = 852 Score = 42.5 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 59/277 (21%), Positives = 103/277 (37%), Gaps = 40/277 (14%) Query: 86 YRIGKIEGFEVLK--KVKTLCLRQN----LIKCIENLEELQSLRELDLYDNQIKKIEN-L 138 I K + F + + L + N IK L + S + + + Sbjct: 496 IDIAKKDSFSNPEGLNCRHLGISGNFDEKQIKVNHKLRGVVSTTKTGEVNKLNSDLAKKF 555 Query: 139 EALTELEILDISFN-----LLRNIEGVDKLTRLKKLFLVNNK--ISKIENLSNLHQLQML 191 L +LDIS + L ++ + L L L L N I ++ +LH LQ+L Sbjct: 556 TDCKYLRVLDISKSIFDAPLSEILDEIASLQHLACLSLSNTHPLIQFPRSMEDLHNLQIL 615 Query: 192 ELGSNRIRAIENIDTLTNL--ESLFLGKNKITKLQNLD-ALTNLTVLSM-------QSNR 241 + + ++ + L + L L L+ + +L L + +SN Sbjct: 616 DASY--CQNLKQLQPCIVLFKKLLVLDMTNCGSLECFPKGIGSLVKLEVLLGFKPARSNN 673 Query: 242 LTKIEGLQNLVNLRELYLSHN---GI--EVIEGLENNNKLTMLDIA------SNRIKKIE 290 K+ ++NL NLR+L LS I E ++ L N +KL + I + I KI+ Sbjct: 674 GCKLSEVKNLTNLRKLGLSLTRGDQIEEEELDSLINLSKLMSISINCYDSYGDDLITKID 733 Query: 291 NISHLTELQEFWMN---DNLLESWSDLDELKGARSLE 324 ++ +L E + SW +L R + Sbjct: 734 ALTPPHQLHELSLQFYPGKSSPSWLSPHKLPMLRYMS 770 Score = 38.6 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 34/167 (20%), Positives = 70/167 (41%), Gaps = 29/167 (17%) Query: 91 IEGFEVLKKVKTLC----LRQNLIKCIENLEELQSLRELDLY---DNQI--KKIENLEAL 141 +G L K++ L R N + ++ L +LR+L L +QI +++++L L Sbjct: 651 PKGIGSLVKLEVLLGFKPARSNNGCKLSEVKNLTNLRKLGLSLTRGDQIEEEELDSLINL 710 Query: 142 TELEILDI------SFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQML---- 191 ++L + I +L+ I+ + +L +L L + + H+L ML Sbjct: 711 SKLMSISINCYDSYGDDLITKIDALTPPHQLHELSLQFYPGKSSPSWLSPHKLPMLRYMS 770 Query: 192 ELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQ 238 N ++ E + +N +++ L L++L+ L M Sbjct: 771 ICSGNLVKMQEPF---------WGNENTHWRIEGL-MLSSLSDLDMD 807 >4NUY-A nrPDB Length = 899 Score = 41.7 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 35/141 (24%), Positives = 55/141 (39%), Gaps = 20/141 (14%) Query: 168 KLFLVNNKISKIENLSNLHQLQMLEL-GSNRIRAI----------ENIDTLTNLESLFLG 216 L L N I +E L+ +L L+L G +RI + DTL + + Sbjct: 387 TLRLDNPAIQSLEGLNKFKKLAQLDLIGLSRITKLDRSVLPANMKPGKDTLETVLETYKK 446 Query: 217 KNKITK--LQNLD----ALTNLTVLSMQSNRLTKIEGLQN--LVNLRELYLSHNGIEVIE 268 NK + + LT L L + + GL L +L ++ +S N +++ Sbjct: 447 DNKEEPATIPPVSLKVSGLTGLKELDLSGFDRETLAGLDAATLTSLEKVDISGNKLDLAP 506 Query: 269 GLENNNKL-TMLDIASNRIKK 288 G EN TML SN + Sbjct: 507 GTENRQIFDTMLSTISNHVGS 527 >2CA6-A nrPDB Length = 386 Score = 40.9 bits (94), Expect = 8e-04, Method: Composition-based stats. Identities = 43/223 (19%), Positives = 76/223 (34%), Gaps = 47/223 (21%) Query: 185 LHQLQMLELGSN------RIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSM- 237 +L + L N + I+ + T LE L+L N + L L++ Sbjct: 93 CPKLHTVRLSDNAFGPTAQEPLIDFLSKHTPLEHLYLHNNGLGPQAGAKIARALQELAVN 152 Query: 238 --------------QSNRLTKIE------GLQNLVNLRELYLSHNGIEV-------IEGL 270 NRL Q+ L + + NGI +EGL Sbjct: 153 KKAKNAPPLRSIICGRNRLENGSMKEWAKTFQSHRLLHTVKMVQNGIRPEGIEHLLLEGL 212 Query: 271 ENNNKLTMLDIASNRIKKIEN------ISHLTELQEFWMNDNLLESWSDLDELKGARSLE 324 +L +LD+ N + + + L+E +ND LL + + LE Sbjct: 213 AYCQELKVLDLQDNTFTHLGSSALAIALKSWPNLRELGLNDCLLSARGAAAVVDAFSKLE 272 Query: 325 -----TVYLERNPLQKDPQYRRKVML--ALPSVRQIDATFVRF 360 T+ L+ N ++ D K ++ +P + ++ RF Sbjct: 273 NIGLQTLRLQYNEIELDAVRTLKTVIDEKMPDLLFLELNGNRF 315 >6MDV-A nrPDB Length = 802 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 27/113 (23%), Positives = 50/113 (44%), Gaps = 5/113 (4%) Query: 167 KKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNL 226 K L L +KI ++ L L +LQ LEL ++ ++ I ES+ + + + Sbjct: 381 KTLVLTGDKIQNLKGLEKLSKLQKLELR--QLSNVKEITPELLPESMKKDAELV--MVGM 436 Query: 227 DALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTML 279 L L + + L I + ++ +L +SHN +++ E E+ L L Sbjct: 437 TGLEKLNLSGLNRQTLDGI-DVNSITHLTSFDISHNSLDLSEKSEDRKLLMTL 488 >4PEQ-B nrPDB Length = 456 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 67/328 (20%), Positives = 117/328 (35%), Gaps = 64/328 (19%) Query: 91 IEGFEVLK-KVKTLCLRQNLIK------CIENLEELQSLRELDLYDNQ-----IKKIEN- 137 ++G + K++ L L+ + L L +LREL L DN ++ + Sbjct: 72 LQGLQSPTCKIQKLSLQNCCLTEAGCGVLPGVLRSLPTLRELHLSDNPLGDAGLRLLCEG 131 Query: 138 -LEALTELEILDISFNLLRN-----IEGVDKLTR-LKKLFLVNNKISK--IENL-----S 183 L+ LE L + + L + V + TR LK+L + NN I + ++ L Sbjct: 132 LLDPRCRLEKLQLEYCSLTAASCEPLAAVLRATRDLKELVVSNNDIGEAGVQALCRGLAE 191 Query: 184 NLHQLQMLELGSNRIRAIENIDTL------TNLESLFLGKNKITKL-------QNLDALT 230 + QL+ L+L + + A D +L+ L LG N++ L + Sbjct: 192 SACQLETLKLENCGLTAANCKDLCGIVASQASLKDLDLGSNRLGDAGLAELCPGLLSPSS 251 Query: 231 NLTVLSMQSNRLTKIEG------LQNLVNLRELYLSHNGIEV-------IEGLENNNKLT 277 L L + LT LQ L+EL L+ N + L+ +L Sbjct: 252 QLRTLWLWECDLTVSGCRELCRVLQAKEALKELSLAGNSLGDEGAQLLCESLLQPGCQLE 311 Query: 278 MLDIASNRIKKIENISHLTELQ------EFWMNDNLLESWSDLDELKGA----RSLETVY 327 L + S + L E ++ N L + L ++ Sbjct: 312 SLWVKSCGFTAACCQHFSSMLTQNKHLLELQLSSNPLGDAGVHVLCQALGQPGTVLRVLW 371 Query: 328 LERNPLQKDPQYRR-KVMLALPSVRQID 354 + L ++LA PS+R++D Sbjct: 372 VGDCELTNSSCGGLASLLLASPSLRELD 399 Score = 34.7 bits (78), Expect = 0.058, Method: Composition-based stats. Identities = 66/353 (18%), Positives = 111/353 (31%), Gaps = 94/353 (26%) Query: 94 FEVLKKVKTLCLRQNLIKCIEN-------LEELQSLRELDLYDNQI------KKIENLEA 140 L ++ L L N + L+ L +L L + L A Sbjct: 104 LRSLPTLRELHLSDNPLGDAGLRLLCEGLLDPRCRLEKLQLEYCSLTAASCEPLAAVLRA 163 Query: 141 LTELEILDISFNLLRNIEGVDKLTR--------LKKLFLVNNKIS--KIENL----SNLH 186 +L+ L +S N + GV L R L+ L L N ++ ++L ++ Sbjct: 164 TRDLKELVVSNNDIGEA-GVQALCRGLAESACQLETLKLENCGLTAANCKDLCGIVASQA 222 Query: 187 QLQMLELGSNRI-------RAIENIDTLTNLESLFLGKNKITK------LQNLDALTNLT 233 L+ L+LGSNR+ + + L +L+L + +T + L A L Sbjct: 223 SLKDLDLGSNRLGDAGLAELCPGLLSPSSQLRTLWLWECDLTVSGCRELCRVLQAKEALK 282 Query: 234 VLSMQSN-------RLTKIEGLQNLVNLRELYL-SHNGIEV-----IEGLENNNKLTMLD 280 LS+ N +L LQ L L++ S L N L L Sbjct: 283 ELSLAGNSLGDEGAQLLCESLLQPGCQLESLWVKSCGFTAACCQHFSSMLTQNKHLLELQ 342 Query: 281 IASNRIKKI-----------------------------------ENISHLTELQEFWMND 305 ++SN + + L+E +++ Sbjct: 343 LSSNPLGDAGVHVLCQALGQPGTVLRVLWVGDCELTNSSCGGLASLLLASPSLRELDLSN 402 Query: 306 NLLESWSDLDELKGAR----SLETVYLERNPLQKDPQYRRKVM-LALPSVRQI 353 N L L L SLE + L + R + + + P +R I Sbjct: 403 NGLGDPGVLQLLGSLEQPACSLEQLVLYDIYWTEAVDERLRAVEESKPGLRII 455 >2Q4G-W nrPDB Length = 461 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 52/281 (18%), Positives = 96/281 (34%), Gaps = 59/281 (20%) Query: 91 IEGFEVLK-KVKTLCLRQNLIKCI------ENLEELQSLRELDLYDNQIKK--------- 134 ++G + K++ L L+ + L L +L+EL L DN + Sbjct: 77 LQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEG 136 Query: 135 -IENLEALT--ELEILDISFNLLRNIEGVDKL-TRLKKLFLVNNKISK------IENLSN 184 ++ L +LE +S + V + K+L + NN I++ + L + Sbjct: 137 LLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKD 196 Query: 185 LHQ-LQMLEL------GSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALT------- 230 L+ L+L N + + +L L LG NK+ + + Sbjct: 197 SPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSS 256 Query: 231 NLTVLSMQSNRLTKIEG------LQNLVNLRELYLSHNGIEVIEG-------LENNNKLT 277 L L + +T L+ +L+EL L+ N + LE +L Sbjct: 257 RLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLE 316 Query: 278 MLDIASNRIKKIE------NISHLTELQEFWMNDNLLESWS 312 L + S ++ L E +++N LE Sbjct: 317 SLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAG 357 >2BNH-A nrPDB Length = 457 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 48/231 (20%), Positives = 81/231 (35%), Gaps = 42/231 (18%) Query: 91 IEGFEVLK-KVKTLCLRQNLIK------CIENLEELQSLRELDLYDNQ-----IKKIEN- 137 ++G + K++ L L+ + L L +LREL L DN ++ + Sbjct: 73 LQGLQSPTCKIQKLSLQNCSLTEAGCGVLPSTLRSLPTLRELHLSDNPLGDAGLRLLCEG 132 Query: 138 -LEALTELEILDISFNLLRN-----IEGVDKLTR-LKKLFLVNNKISKIENLSNLHQLQM 190 L+ LE L + + L + V + TR LK+L + NN I + L Sbjct: 133 LLDPQCHLEKLQLEYCRLTAASCEPLASVLRATRALKELTVSNNDIGEAGARVLGQGLAD 192 Query: 191 LELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKI----- 245 +R T N + L + + +L L + SN L Sbjct: 193 SACQLETLRLENCGLTPANCKDL---------CGIVASQASLRELDLGSNGLGDAGIAEL 243 Query: 246 -EGLQNLVN-LRELYLSHNGIEVI------EGLENNNKLTMLDIASNRIKK 288 GL + + L+ L+L I L+ L L +A N++ Sbjct: 244 CPGLLSPASRLKTLWLWECDITASGCRDLCRVLQAKETLKELSLAGNKLGD 294 Score = 30.9 bits (68), Expect = 0.88, Method: Composition-based stats. Identities = 44/213 (20%), Positives = 70/213 (32%), Gaps = 49/213 (23%) Query: 121 SLRELDLYDNQ-----IKKIEN--LEALTELEILDISFNLLRN------IEGVDKLTRLK 167 SLRELDL N I ++ L + L+ L + + + LK Sbjct: 224 SLRELDLGSNGLGDAGIAELCPGLLSPASRLKTLWLWECDITASGCRDLCRVLQAKETLK 283 Query: 168 KLFLVNNKISK----------IENLSNLHQLQMLELGSNRIRAIENIDTL---TNLESLF 214 +L L NK+ ++ L L + L +L L Sbjct: 284 ELSLAGNKLGDEGARLLCESLLQPGCQLESLWVKSCSLTAACCQHVSLMLTQNKHLLELQ 343 Query: 215 LGKNKITK--LQNL-----DALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVI 267 L NK+ +Q L T L VL + +T G +L +L Sbjct: 344 LSSNKLGDSGIQELCQALSQPGTTLRVLCLGDCEVTN-SGCSSLASL------------- 389 Query: 268 EGLENNNKLTMLDIASNRIKKIENISHLTELQE 300 L N L LD+++N + + L L++ Sbjct: 390 --LLANRSLRELDLSNNCVGDPGVLQLLGSLEQ 420 >4PBW-B nrPDB Length = 283 Score = 36.7 bits (83), Expect = 0.016, Method: Composition-based stats. Identities = 29/127 (22%), Positives = 47/127 (37%), Gaps = 23/127 (18%) Query: 216 GKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNK 275 N T +Q D N+T + IE +NL L + +E Sbjct: 36 SSNGQTSIQITDISRNITSIH--------IENWKNLQTLNAVD-----------MELYTG 76 Query: 276 LTMLDIASNRIKKIEN--ISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPL 333 L L I ++ ++ I+ + L+ ++ N L + S +L L + LERNP Sbjct: 77 LQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLS--WQLFQTLRLFDLRLERNPF 134 Query: 334 QKDPQYR 340 Q R Sbjct: 135 QCSCDIR 141 Score = 36.7 bits (83), Expect = 0.017, Method: Composition-based stats. Identities = 29/159 (18%), Positives = 62/159 (38%), Gaps = 23/159 (14%) Query: 99 KVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIE 158 ++ + +N+ ++E ++L+ L+ D ++ T L+ L I + LRNI+ Sbjct: 42 SIQITDISRNITSI--HIENWKNLQTLNAVDMEL--------YTGLQRLTIRNSGLRNIQ 91 Query: 159 --GVDKLTRLKKLFLVNNKISKI--ENLSNLHQLQMLELGSNRIRA--------IENIDT 206 K L+ + L N+++ + + L +L L L N + + Sbjct: 92 PRAFAKNPHLRYIDLSGNRLTTLSWQLFQTL-RLFDLRLERNPFQCSCDIRWIQLWQEKG 150 Query: 207 LTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKI 245 NL+S L + L N+T + ++ + Sbjct: 151 EANLQSQQLHCMNLDTAVILLRNMNITQCDLPEISVSHV 189 >3TSR-E nrPDB Length = 457 Score = 36.3 bits (82), Expect = 0.021, Method: Composition-based stats. Identities = 61/359 (16%), Positives = 125/359 (34%), Gaps = 73/359 (20%) Query: 65 LPVDMETINLDRDAEDVDLNHYRIGKI------EGFEVLK-KVKTLCLRQNLIKCIENLE 117 LP + +++ R+ + LN +G EG + + +++ L L + Sbjct: 101 LPGMLRSLSTLRE---LHLNDNPMGDAGLKLLCEGLQDPQCRLEKLQLEYCNLTATSCEP 157 Query: 118 ELQSLR------ELDLYDNQIK------KIENLEALT-ELEILDISFNLLRNI------E 158 LR EL L +N + + L+ +LE L + + + Sbjct: 158 LASVLRVKADFKELVLSNNDLHEPGVRILCQGLKDSACQLESLKLENCGITAANCKDLCD 217 Query: 159 GVDKLTRLKKLFLVNNKISKIENLSNLH-------QLQMLELGSNRIRAIENIDTLT--- 208 V L++L L +NK+ + +L+ L L I A D Sbjct: 218 VVASKASLQELDLSSNKLGNAGIAALCPGLLLPSCKLRTLWLWECDITAEGCKDLCRVLR 277 Query: 209 ---NLESLFLGKNKITKLQN-------LDALTNLTVLSMQSNRLTKIEG------LQNLV 252 +L+ L L N++ L+ L L +++ LT L Sbjct: 278 AKQSLKELSLASNELKDEGARLLCESLLEPGCQLESLWIKTCSLTAASCPYFCSVLTKSR 337 Query: 253 NLRELYLSHNGI---------EVIEGLENNNKLTML---DIASNRIKKIENISHLT-ELQ 299 +L EL +S N + + + + + L D+ ++ + N+ L+ Sbjct: 338 SLLELQMSSNPLGDEGVQELCKALSQPDTVLRELWLGDCDVTNSGCSSLANVLLANRSLR 397 Query: 300 EFWMNDNLLESWSDLDELKGAR----SLETVYLERNPLQKDPQYRRKVM-LALPSVRQI 353 E +++N + L L+ + +L+ + L + + + + + PS+R I Sbjct: 398 ELDLSNNCMGGPGVLQLLESLKQPSCTLQQLVLYDIYWTNEVEEQLRALEEERPSLRII 456 >4PBV-A nrPDB Length = 268 Score = 34.7 bits (78), Expect = 0.066, Method: Composition-based stats. Identities = 30/151 (19%), Positives = 56/151 (37%), Gaps = 20/151 (13%) Query: 106 RQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIE--GVDKL 163 I I +E ++L+ L+ D ++ T L+ L I + LRNI+ K Sbjct: 33 DSRNITSIH-IENWKNLQTLNAVDMEL--------YTGLQRLTIRNSGLRNIQPRAFAKN 83 Query: 164 TRLKKLFLVNNKISKIE-NLSNLHQLQMLELGSNRIRA--------IENIDTLTNLESLF 214 L+ + L N+++ + L +L L L N + + NL+S Sbjct: 84 PHLRYIDLSGNRLTTLSWQLFQTLRLFDLRLERNPFQCSCDIRWIQLWQEKGEANLQSQQ 143 Query: 215 LGKNKITKLQNLDALTNLTVLSMQSNRLTKI 245 L + L N+T + ++ + Sbjct: 144 LHCMNLDTAVILLRNMNITQCDLPEISVSHV 174 Score = 34.4 bits (77), Expect = 0.074, Method: Composition-based stats. Identities = 25/105 (23%), Positives = 42/105 (40%), Gaps = 13/105 (12%) Query: 238 QSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIEN--ISHL 295 S +T I ++N NL+ L +E L L I ++ ++ I+ + Sbjct: 33 DSRNITSI-HIENWKNLQTLN--------AVDMELYTGLQRLTIRNSGLRNIQPRAFAKN 83 Query: 296 TELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYR 340 L+ ++ N L + S +L L + LERNP Q R Sbjct: 84 PHLRYIDLSGNRLTTLS--WQLFQTLRLFDLRLERNPFQCSCDIR 126 >3G04-C nrPDB Length = 239 Score = 32.4 bits (72), Expect = 0.34, Method: Composition-based stats. Identities = 23/122 (18%), Positives = 48/122 (39%), Gaps = 12/122 (9%) Query: 220 ITKLQNLDALTNLTVLSMQSNRLTKIE--GLQNLVNLRELYLS----HNGIEVIEGLENN 273 I ++ +L + L + L I NL N+ +Y+S +E N Sbjct: 23 IQRIPSLP--PSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLES-HSFYNL 79 Query: 274 NKLTMLDIASNRIKKIEN---ISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLER 330 +K+T ++I + R + + L L+ + + L+ + DL ++ + + Sbjct: 80 SKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITD 139 Query: 331 NP 332 NP Sbjct: 140 NP 141 >1X9N-A nrPDB Length = 688 Score = 29.7 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 11/35 (31%), Positives = 15/35 (42%) Query: 230 TNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGI 264 L ++ SN L + L L LYLS N + Sbjct: 73 ARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHL 107 >4NOI-A nrPDB Length = 361 Score = 29.7 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 28/182 (15%), Positives = 64/182 (35%), Gaps = 17/182 (9%) Query: 57 EDPEEEHELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENL 116 ED E + L V+ + + +N + ++ F + T + + L + + Sbjct: 159 EDAELKFTLIVEKGIGYVPSEEIKELINDPKFIALDAFFTPVREATYDIEKVLFEDNPDY 218 Query: 117 EELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKI 176 E++ D QI E + L+ + L + + + + K +N++ Sbjct: 219 EKVVLTVT---TDGQITPNEAFQ-----NALEAMYKQLSVFDKITNVRSVIKNQATSNEL 270 Query: 177 SKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLS 236 + L N+ L + N + +++G+ + + L L NL S Sbjct: 271 ENTKLLQNITDLNLSARSYNCLEKAGV---------VYIGELALMSVSELAGLKNLGKKS 321 Query: 237 MQ 238 + Sbjct: 322 LD 323 >3R2W-A nrPDB Length = 528 Score = 29.7 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 19/63 (30%), Positives = 29/63 (46%), Gaps = 1/63 (1%) Query: 35 HSSGIVADLSEQSLKDGEERGEEDPEEEHELPVDMETINLDRDAEDVDLNHYRIGKIEGF 94 H S V DLS+ +DG + +E +E EL V E + A + H + ++GF Sbjct: 20 HMSRFVQDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTK-KDLDGF 78 Query: 95 EVL 97 L Sbjct: 79 RKL 81 >5EE0-A nrPDB Length = 395 Score = 29.0 bits (63), Expect = 3.7, Method: Composition-based stats. Identities = 21/84 (25%), Positives = 35/84 (41%), Gaps = 7/84 (8%) Query: 104 CLRQNLIKCI----ENLEELQS--LRELDLYDNQIKKIENLEALTELEILDISFNLLRNI 157 L N I + E L + L + D + E E+ +D S + +R++ Sbjct: 90 YLEINDIAGLVRGAHAGEGLGNAFLSHIRAVDGIFHVLRAFED-KEVTHIDDSVDPVRDL 148 Query: 158 EGVDKLTRLKKLFLVNNKISKIEN 181 E + + RLK + V NKI +E Sbjct: 149 ETIGEELRLKDIEFVQNKIDDLEK 172 >2AXV-A nrPDB Length = 317 Score = 28.2 bits (61), Expect = 6.6, Method: Composition-based stats. Identities = 16/111 (14%), Positives = 34/111 (30%), Gaps = 2/111 (1%) Query: 230 TNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKI 289 NL N+ ++ ++N+ L N ++ I + + A N I Sbjct: 205 RNLKEAQYYINQFEHLKTIKNISINGYYDLEINYLKQIYQFLTDKNIDSYLNAVNIINIF 264 Query: 290 ENISHLTELQEFWMNDNLLESWSDLDELKGARSL--ETVYLERNPLQKDPQ 338 + I + + + K V +E NP+ + + Sbjct: 265 KIIGKEDIHRSLVEELTKISAKEKFTPPKEVTMYYENYVAIENNPIPEIKE 315 >2L3O-A nrPDB Length = 127 Score = 27.4 bits (59), Expect = 8.6, Method: Composition-based stats. Identities = 16/64 (25%), Positives = 32/64 (50%), Gaps = 4/64 (6%) Query: 52 EERGEEDPEEEHELPVDMETIN--LDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNL 109 E +GE DPE+ + + +++ +N L A D L I ++ F KK++ + N Sbjct: 54 ESQGEVDPEDRYVIKSNLQKLNACLPTSANDSALPGVFIRDLDDFR--KKLRFYMVHLND 111 Query: 110 IKCI 113 ++ + Sbjct: 112 LETV 115 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.306 0.126 0.289 Lambda K H 0.267 0.0392 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 10,446,068 Number of Sequences: 36641 Number of extensions: 374100 Number of successful extensions: 2693 Number of sequences better than 10.0: 82 Number of HSP's better than 10.0 without gapping: 76 Number of HSP's successfully gapped in prelim test: 99 Number of HSP's that attempted gapping in prelim test: 1131 Number of HSP's gapped (non-prelim): 495 length of query: 360 length of database: 10,336,785 effective HSP length: 98 effective length of query: 262 effective length of database: 6,745,967 effective search space: 1767443354 effective search space used: 1767443354 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.6 bits) S2: 59 (27.4 bits)