BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q15046 (597 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6CHD-A nrPDB 1244 0.0 6ILH-A nrPDB 1073 0.0 5HGQ-A nrPDB 733 0.0 5ELO-A nrPDB 608 e-174 4YCV-A nrPDB 577 e-165 4UP8-A nrPDB 558 e-159 1LYL-A nrPDB 412 e-115 1BBU-A nrPDB 394 e-110 3A74-A nrPDB 387 e-108 4EX5-A nrPDB 352 2e-97 6NRZ-A nrPDB 330 1e-90 6AQH-A nrPDB 307 1e-83 6AQG-A nrPDB 306 1e-83 3A5Z-A nrPDB 126 2e-29 3G1Z-A nrPDB 122 6e-28 1WYD-A nrPDB 117 1e-26 3NEM-A nrPDB 101 9e-22 4WJ3-M nrPDB 97 2e-20 5W25-A nrPDB 84 1e-16 1IL2-A nrPDB 84 2e-16 4J15-A nrPDB 84 2e-16 4RMF-A nrPDB 84 2e-16 1EFW-A nrPDB 81 2e-15 1ASZ-A nrPDB 80 3e-15 6OD8-A nrPDB 76 4e-14 4AH6-A nrPDB 75 9e-14 3I7F-A nrPDB 74 2e-13 1N9W-A nrPDB 69 8e-12 5XIX-A nrPDB 46 5e-05 3P8T-A nrPDB 45 8e-05 1X54-A nrPDB 44 3e-04 1NNH-A nrPDB 42 6e-04 2XGT-A nrPDB 40 0.003 3M4P-A nrPDB 39 0.008 3VQX-A nrPDB 34 0.15 2W57-A nrPDB 32 0.60 4MZD-A nrPDB 32 0.65 5VXO-A nrPDB 32 0.66 6HA8-V nrPDB 30 2.0 3G17-A nrPDB 30 2.0 5ZG8-A nrPDB 30 2.3 6MN8-A nrPDB 30 3.3 6JP2-A nrPDB 30 4.4 4PI7-A nrPDB 29 5.6 3Q5R-A nrPDB 28 7.9 >6CHD-A nrPDB Length = 597 Score = 1244 bits (3219), Expect = 0.0, Method: Compositional matrix adjust. Identities = 597/597 (100%), Positives = 597/597 (100%) Query: 1 MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTT 60 MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTT Sbjct: 1 MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTT 60 Query: 61 DNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH 120 DNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH Sbjct: 61 DNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH 120 Query: 121 LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD 180 LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD Sbjct: 121 LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD 180 Query: 181 IIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFV 240 IIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFV Sbjct: 181 IIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFV 240 Query: 241 RQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAP 300 RQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAP Sbjct: 241 RQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAP 300 Query: 301 ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSG 360 ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSG Sbjct: 301 ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSG 360 Query: 361 MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR 420 MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR Sbjct: 361 MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR 420 Query: 421 KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE 480 KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE Sbjct: 421 KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE 480 Query: 481 GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG 540 GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG Sbjct: 481 GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG 540 Query: 541 LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV 597 LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV Sbjct: 541 LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV 597 >6ILH-A nrPDB Length = 521 Score = 1073 bits (2776), Expect = 0.0, Method: Compositional matrix adjust. Identities = 511/513 (99%), Positives = 512/513 (99%) Query: 70 SVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVA 129 SVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVA Sbjct: 2 SVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVA 61 Query: 130 GRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPG 189 GRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPG Sbjct: 62 GRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPG 121 Query: 190 KTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSK 249 KTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSK Sbjct: 122 KTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSK 181 Query: 250 IITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVV 309 IITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVV Sbjct: 182 IITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVV 241 Query: 310 GGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSY 369 GGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHD MEITEKMVSGMVKHITGSY Sbjct: 242 GGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDHMEITEKMVSGMVKHITGSY 301 Query: 370 KVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVA 429 KVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVA Sbjct: 302 KVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVA 361 Query: 430 KAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELF 489 KAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELF Sbjct: 362 KAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELF 421 Query: 490 VMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGM 549 VMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGM Sbjct: 422 VMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGM 481 Query: 550 GIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENV 582 GIDRVAMFLTDSNNIKEVLLFPAMKPEDKKEN+ Sbjct: 482 GIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENL 514 >5HGQ-A nrPDB Length = 524 Score = 733 bits (1892), Expect = 0.0, Method: Compositional matrix adjust. Identities = 338/512 (66%), Positives = 417/512 (81%), Gaps = 1/512 (0%) Query: 72 DPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGR 131 DP +Y+K+R+ I++ + G +PYPHKFHV ISL DFI KY+ L+ L DI VAGR Sbjct: 6 DPQEYFKLRTALINERRSKGINPYPHKFHVSISLADFIAKYNSLEKDVILNDIVQSVAGR 65 Query: 132 IHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKT 191 + +KR SGGKLIFYDL GEG +LQV+AN+R + +E F +++++++RGDIIGV G P ++ Sbjct: 66 VFSKRESGGKLIFYDLHGEGTRLQVLANARFHSGDEAFDNLHDRIKRGDIIGVNGYPARS 125 Query: 192 KKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKII 251 K GELSIIPYEI L+PCLHMLPH HFGLK++ETRYR RYLDLI+N V+ +F+ RS++I Sbjct: 126 KSGELSIIPYEIIQLTPCLHMLPHTHFGLKNQETRYRMRYLDLIMNPDVKNRFVTRSRMI 185 Query: 252 TYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGG 311 +++R +LD LGFLE+ETPMMN+I GGA AKPFIT+HN+LDM+LY+R+APELY KMLVVGG Sbjct: 186 SFLRRYLDNLGFLEVETPMMNLIAGGATAKPFITHHNDLDMDLYLRVAPELYLKMLVVGG 245 Query: 312 IDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKV 371 IDRVYEIGR FRNEGID THNPEFT+CEFYMAYADY DLM+ITE M++ MV ++ G+YK+ Sbjct: 246 IDRVYEIGRVFRNEGIDQTHNPEFTSCEFYMAYADYEDLMKITEDMLARMVYYMHGTYKI 305 Query: 372 TYHPDG-PEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAK 430 YHP+G E Y+VDFTPPFR++N+ + L++ LG++ P + +T+E K D + V Sbjct: 306 QYHPNGIVENPVYEVDFTPPFRKVNIYDGLQEKLGIQFPPADTLDTDEANKFFDKLAVEN 365 Query: 431 AVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFV 490 VECP PRTTARLLDKL+GEFLE T I+PTF+ HPQIMSPLAKWHRS GLTERFELFV Sbjct: 366 NVECPAPRTTARLLDKLIGEFLEPTFISPTFLTGHPQIMSPLAKWHRSIPGLTERFELFV 425 Query: 491 MKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMG 550 + KEI NAYTELNDP+ QR F+EQAK K AGDDEA IDEN+CTALEYGLPPTAGWGMG Sbjct: 426 VTKEIVNAYTELNDPLTQRLRFDEQAKQKQAGDDEAQNIDENYCTALEYGLPPTAGWGMG 485 Query: 551 IDRVAMFLTDSNNIKEVLLFPAMKPEDKKENV 582 IDR+AM LTDSNNIKEVL FPAM+P++K NV Sbjct: 486 IDRLAMILTDSNNIKEVLFFPAMRPDEKGTNV 517 >5ELO-A nrPDB Length = 535 Score = 608 bits (1568), Expect = e-174, Method: Compositional matrix adjust. Identities = 289/510 (56%), Positives = 377/510 (73%), Gaps = 4/510 (0%) Query: 67 EEESVDPNQYYK-IRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDIT 125 E ++ P +Y R + + +K G YPHKF + +SL + KY +++ G D T Sbjct: 13 EAQTQGPGSHYTDNRYKMMECIKDAGRPFYPHKFKISMSLPAYALKYGNVENGYIDKDTT 72 Query: 126 LKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYK-SEEEFIHINNKLRRGDIIGV 184 L ++GR+ + R+S KLIFYD+ E K+Q++AN + S EF ++++RRGD++G Sbjct: 73 LSLSGRVTSIRSSSSKLIFYDIFCEEQKVQIIANIMEHDISTGEFSVSHSEIRRGDVVGF 132 Query: 185 QGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKF 244 G PGK+K+GELS+ + LLSPC HMLP GLKD+E RYRQRYLDL+LN+ R+ F Sbjct: 133 TGFPGKSKRGELSLFSKSVVLLSPCYHMLPTAISGLKDQEVRYRQRYLDLMLNEESRKVF 192 Query: 245 IIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYH 304 +RS+ I YIR++ D LGFLE+ETPM+N+I GGA A+PFITYHNEL+ LYMRIAPELY Sbjct: 193 KLRSRAIKYIRNYFDRLGFLEVETPMLNMIYGGAAARPFITYHNELETQLYMRIAPELYL 252 Query: 305 KMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKH 364 K L+VGG+D+VYEIG+ FRNEGIDLTHNPEFT EFYMAYADY+DLM++TE+++SG+V Sbjct: 253 KQLIVGGLDKVYEIGKNFRNEGIDLTHNPEFTAMEFYMAYADYYDLMDLTEELISGLVLE 312 Query: 365 ITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILD 424 I GS K+ YHPDGPEG+ ++DFT P++R + VEE+E LG KL +++E + Sbjct: 313 IHGSLKIPYHPDGPEGKCIEIDFTTPWKRFSFVEEIESGLGEKLKRP--LDSQENIDFMV 370 Query: 425 DICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTE 484 ++C +E P PRT A+LLDKL G F+E C NP+FI DHPQ MSPLAKWHR K +TE Sbjct: 371 EMCEKHEIELPHPRTAAKLLDKLAGHFVETKCTNPSFIIDHPQTMSPLAKWHREKPEMTE 430 Query: 485 RFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPT 544 RFELFV+ KE+CNAYTELN+P++QR+ FE+QA AKA+GD EA IDE FC ALE+GLPPT Sbjct: 431 RFELFVLGKELCNAYTELNEPLQQRKFFEQQADAKASGDVEACPIDETFCLALEHGLPPT 490 Query: 545 AGWGMGIDRVAMFLTDSNNIKEVLLFPAMK 574 GWG+GIDR+ MFL D NNIKEV+LFPAM+ Sbjct: 491 GGWGLGIDRLIMFLADKNNIKEVILFPAMR 520 >4YCV-A nrPDB Length = 516 Score = 577 bits (1488), Expect = e-165, Method: Compositional matrix adjust. Identities = 280/509 (55%), Positives = 373/509 (73%), Gaps = 5/509 (0%) Query: 71 VDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAG 130 VDP Y++ RS+ I K G +PYPHKF IS+ +FI+KY L G+HL D L + G Sbjct: 3 VDPRLYFENRSKFIQDQKDKGINPYPHKFERTISIPEFIEKYKDLGNGEHLEDTILNITG 62 Query: 131 RIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEE-EFIHINNKLRRGDIIGVQGNPG 189 RI ASG KL F+DL G+G K+QV+AN + E+ F +K+RRGDI+G+ G PG Sbjct: 63 RIMRVSASGQKLRFFDLVGDGEKIQVLANYSFHNHEKGNFAECYDKIRRGDIVGIVGFPG 122 Query: 190 KTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSK 249 K+KKGELSI P E LLS CLHMLP + +GLKD E RYRQRYLDL++N+ R F+ R+K Sbjct: 123 KSKKGELSIFPKETILLSACLHMLP-MKYGLKDTEIRYRQRYLDLLINESSRHTFVTRTK 181 Query: 250 IITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVV 309 II ++R+FL+E GF E+ETPMMN+I GGA A+PFIT+HN+LD++LY+RIA EL KML+V Sbjct: 182 IINFLRNFLNERGFFEVETPMMNLIAGGANARPFITHHNDLDLDLYLRIATELPLKMLIV 241 Query: 310 GGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSY 369 GGID+VYEIG+ FRNEGID THNPEFT+CEFY AYADY+DL++ +E S +V H+ G+Y Sbjct: 242 GGIDKVYEIGKVFRNEGIDNTHNPEFTSCEFYWAYADYNDLIKWSEDFFSQLVYHLFGTY 301 Query: 370 KVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVA 429 K++Y+ DGPE Q ++DFTPP+ ++++VEE+EK L + F++ ET + + +I Sbjct: 302 KISYNKDGPENQPIEIDFTPPYPKVSIVEEIEKVTNTILEQP--FDSNETIEKMINIIKE 359 Query: 430 KAVECPPPRTTARLLDKLVGEFLEVTCIN-PTFICDHPQIMSPLAKWHRSKEGLTERFEL 488 +E P P T A+LLD+L F+E + P FI +HPQIMSPLAK+HR+K GLTER E+ Sbjct: 360 HKIELPNPPTAAKLLDQLASHFIENKYNDKPFFIVEHPQIMSPLAKYHRTKPGLTERLEM 419 Query: 489 FVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWG 548 F+ KE+ NAYTELNDP +Q++ F+ Q K + GD EA +D FCT+LEYGLPPT G G Sbjct: 420 FICGKEVLNAYTELNDPFKQKECFKLQQKDREKGDTEAAQLDSAFCTSLEYGLPPTGGLG 479 Query: 549 MGIDRVAMFLTDSNNIKEVLLFPAMKPED 577 +GIDR+ MFLT+ N+IK+V+LFP M+P + Sbjct: 480 LGIDRITMFLTNKNSIKDVILFPTMRPAN 508 >4UP8-A nrPDB Length = 777 Score = 558 bits (1438), Expect = e-159, Method: Compositional matrix adjust. Identities = 275/569 (48%), Positives = 372/569 (65%), Gaps = 63/569 (11%) Query: 75 QYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHA 134 Q + R + + + + G +P+PHKF+V I++ +FI KYS L+ ++D + VAGR+ + Sbjct: 12 QLFLNRCKDVEEYQKAGHNPWPHKFNVSITVPEFIAKYSGLEKS-QVSDDIVSVAGRVLS 70 Query: 135 KRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKG 194 KR+S L+F DL KLQ+M N Y+++E+F+ + + RGDI G G+P +TK G Sbjct: 71 KRSSSSALMFIDLHDSQTKLQIMLNKSAYENKEDFVSLTKMIYRGDICGFTGHPTRTKTG 130 Query: 195 ELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYI 254 ELS+IP +LSPCLHMLP +H+GL D+ETR+R+RYLDLI+N + F++R+K++ + Sbjct: 131 ELSLIPISGMILSPCLHMLPSMHYGLGDQETRFRKRYLDLIVNPESVKNFVLRTKVVKAV 190 Query: 255 RSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDR 314 R +LD+ GFLE+ETP++N IPGGA A+PFIT+HN+LD+ +YMRIAPELY K LVVGGI+R Sbjct: 191 RKYLDDKGFLEVETPILNTIPGGATARPFITHHNQLDIQMYMRIAPELYLKELVVGGINR 250 Query: 315 VYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSY----- 369 VYEIGR FRNEGID THNPEFTTCEFYMAYADY+D+M++TE+++ MVK ITG Sbjct: 251 VYEIGRLFRNEGIDQTHNPEFTTCEFYMAYADYNDIMKMTEELLGNMVKDITGGSTKLEI 310 Query: 370 ------------------------------------------KVTYHPDGPEGQAYD--- 384 ++ Y+ DG +A Sbjct: 311 KDRLMDINNEEDIKMLEKFFKEPIPRPFNSAECSKVIEKHCTELNYYYDGNNEKAMKKLF 370 Query: 385 VDF----------TPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVEC 434 DF T PF+RI+ V LE+ G K+P + E L + C Sbjct: 371 ADFVTEKKMVLDFTAPFKRISYVHALEEKFGEKIPRP--LDGPEALTFLKKQAIRFNAIC 428 Query: 435 PPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKE 494 P+TTAR++DKL G+ +EV + PTF+CD PQ+MSPLAK+HRS+ LTERFELF++K+E Sbjct: 429 AEPQTTARVMDKLFGDLIEVDLVQPTFVCDQPQLMSPLAKYHRSEPELTERFELFILKRE 488 Query: 495 ICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRV 554 I NAYTELN+P+ QR FE+QAK KAAGDDEA +DE F A+E+ PPT GWG+GIDR+ Sbjct: 489 IANAYTELNNPIVQRSNFEQQAKDKAAGDDEAQLVDEVFLDAIEHAFPPTGGWGLGIDRL 548 Query: 555 AMFLTDSNNIKEVLLFPAMKPEDKKENVA 583 AM L D +NIKEV+LFP M+PED+ E A Sbjct: 549 AMLLADVDNIKEVILFPTMRPEDELEKKA 577 >1LYL-A nrPDB Length = 504 Score = 412 bits (1059), Expect = e-115, Method: Compositional matrix adjust. Identities = 228/516 (44%), Positives = 319/516 (61%), Gaps = 30/516 (5%) Query: 69 ESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHL--TDITL 126 E++D N + R + + L+ G +P+ F D + +D + + + L +I + Sbjct: 10 EAIDFNDELRNRREKLAALRQQGV-AFPNDFRRDHT-SDQLHEEFDAKDNQELESLNIEV 67 Query: 127 KVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQG 186 VAGR+ +R G K F L+ G ++Q+ +R+ E + K GDIIG +G Sbjct: 68 SVAGRMMTRRIMG-KASFVTLQDVGGRIQLYV-ARDSLPEGVYNDQFKKWDLGDIIGARG 125 Query: 187 NPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFII 246 KT+ GELSI E+ LL+ L LP GL+D+E RYRQRYLDLI ND RQ F++ Sbjct: 126 TLFKTQTGELSIHCTELRLLTKALRPLPDKFHGLQDQEVRYRQRYLDLIANDKSRQTFVV 185 Query: 247 RSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKM 306 RSKI+ IR F+ GF+E+ETPMM +IPGGA A+PFIT+HN LD+++Y+RIAPELY K Sbjct: 186 RSKILAAIRQFMVARGFMEVETPMMQVIPGGASARPFITHHNALDLDMYLRIAPELYLKR 245 Query: 307 LVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHIT 366 LVVGG +RV+EI R FRNEGI + HNPEFT E YMAYADYHDL+E+TE + + + + Sbjct: 246 LVVGGFERVFEINRNFRNEGISVRHNPEFTMMELYMAYADYHDLIELTESLFRTLAQEVL 305 Query: 367 GSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDI 426 G+ KVTY + DF PF ++ M E ++K PET++ + LD+ Sbjct: 306 GTTKVTYGE-------HVFDFGKPFEKLTMREAIKK----YRPETDMAD-------LDNF 347 Query: 427 CVAKA------VECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE 480 AKA + R++ ++ E E I PTFI ++P +SPLA+ + Sbjct: 348 DAAKALAESIGITVEKSWGLGRIVTEIFDEVAEAHLIQPTFITEYPAEVSPLARRNDVNP 407 Query: 481 GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG 540 +T+RFE F+ +EI N ++ELND Q + F+EQ AKAAGDDEAMF DE++ TALEYG Sbjct: 408 EITDRFEFFIGGREIGNGFSELNDAEDQAERFQEQVNAKAAGDDEAMFYDEDYVTALEYG 467 Query: 541 LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPE 576 LPPTAG G+GIDR+ M T+S+ I++V+LFPAM+P+ Sbjct: 468 LPPTAGLGIGIDRMIMLFTNSHTIRDVILFPAMRPQ 503 >1BBU-A nrPDB Length = 504 Score = 394 bits (1012), Expect = e-110, Method: Compositional matrix adjust. Identities = 224/513 (43%), Positives = 311/513 (60%), Gaps = 30/513 (5%) Query: 71 VDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHL--TDITLKV 128 VD N K R + + L+ G +P+ F D + +D + + + L +I + V Sbjct: 12 VDLNNELKTRREKLANLREQG-IAFPNDFRRDHT-SDQLHAEFDGKENEELEALNIEVAV 69 Query: 129 AGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNP 188 AGR+ +R G K F L+ G ++Q+ +R+ E + K GDI+G +G Sbjct: 70 AGRMMTRRIMG-KASFVTLQDVGGRIQLYV-ARDDLPEGVYNEQFKKWDLGDILGAKGKL 127 Query: 189 GKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRS 248 KTK GELSI E+ LL+ L LP GL+D+E RYRQRYLDLI ND R F +RS Sbjct: 128 FKTKTGELSIHCTELRLLTKALRPLPDKFHGLQDQEARYRQRYLDLISNDESRNTFKVRS 187 Query: 249 KIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLV 308 +I++ IR F+ GF+E+ETPMM +IPGGA A+PFIT+HN LD+++Y+RIAPELY K LV Sbjct: 188 QILSGIRQFMVNRGFMEVETPMMQVIPGGAAARPFITHHNALDLDMYLRIAPELYLKRLV 247 Query: 309 VGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGS 368 VGG +RV+EI R FRNEGI + HNPEFT E YMAYADY DL+E+TE + + + I G Sbjct: 248 VGGFERVFEINRNFRNEGISVRHNPEFTMMELYMAYADYKDLIELTESLFRTLAQDILGK 307 Query: 369 YKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICV 428 +VTY +DF PF ++ M E ++K PET++ + LD+ Sbjct: 308 TEVTYGD-------VTLDFGKPFEKLTMREAIKKY----RPETDMAD-------LDNFDS 349 Query: 429 AKA------VECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGL 482 AKA + R++ ++ E E I PTFI ++P +SPLA+ + + Sbjct: 350 AKAIAESIGIHVEKSWGLGRIVTEIFEEVAEAHLIQPTFITEYPAEVSPLARRNDVNPEI 409 Query: 483 TERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLP 542 T+RFE F+ +EI N ++ELND Q Q F +Q AK AGDDEAMF DE++ TALE+GLP Sbjct: 410 TDRFEFFIGGREIGNGFSELNDAEDQAQRFLDQVAAKDAGDDEAMFYDEDYVTALEHGLP 469 Query: 543 PTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKP 575 PTAG G+GIDR+ M T+S+ I++V+LFPAM+P Sbjct: 470 PTAGLGIGIDRMVMLFTNSHTIRDVILFPAMRP 502 >3A74-A nrPDB Length = 493 Score = 387 bits (995), Expect = e-108, Method: Compositional matrix adjust. Identities = 213/503 (42%), Positives = 306/503 (60%), Gaps = 19/503 (3%) Query: 74 NQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGD-HLTDITLKVAGRI 132 N ++R + + +++ G DP+ +F + + Y L + I + VAGRI Sbjct: 6 NDQLRVRREKLKKIEELGVDPFGKRFERTHKAEELFELYGDLSKEELEEQQIEVAVAGRI 65 Query: 133 HAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEE-EFIHINNKLRRGDIIGVQGNPGKT 191 KR G K F ++ ++Q+ + ++ E I++ GDI+GV+G KT Sbjct: 66 MTKRGMG-KAGFAHIQDVTGQIQIYVRQDDVGEQQYELFKISDL---GDIVGVRGTMFKT 121 Query: 192 KKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKII 251 K GELSI L+ L LP + GLKD E RYRQRYLDLI+N ++ FI RS II Sbjct: 122 KVGELSIKVSSYEFLTKALRPLPEKYHGLKDIEQRYRQRYLDLIMNPESKKTFITRSLII 181 Query: 252 TYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGG 311 +R +LD G+LE+ETPMM+ + GGA A+PFIT+HN LDM LYMRIA EL+ K L+VGG Sbjct: 182 QSMRRYLDSHGYLEVETPMMHAVAGGAAARPFITHHNALDMTLYMRIAIELHLKRLIVGG 241 Query: 312 IDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKV 371 +++VYEIGR FRNEGI HNPEFT E Y AYAD+ D+M++TE +++ + + G+ K+ Sbjct: 242 LEKVYEIGRVFRNEGISTRHNPEFTMLELYEAYADFRDIMKLTENLIAHIATEVLGTTKI 301 Query: 372 TYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKA 431 Y + VD TP +RR++MV+ +++ +G+ EE R ++ Sbjct: 302 QY-------GEHLVDLTPEWRRLHMVDAIKEYVGVDF--WRQMSDEEAR----ELAKEHG 348 Query: 432 VECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVM 491 VE P T ++++ + +E I PTFI HP +SPLAK + T+RFELF++ Sbjct: 349 VEVAPHMTFGHIVNEFFEQKVEDKLIQPTFIYGHPVEISPLAKKNPDDPRFTDRFELFIV 408 Query: 492 KKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGI 551 +E NA+TELNDP+ QRQ FEEQ K + G+DEA +DE+F ALEYG+PPT G G+G+ Sbjct: 409 GREHANAFTELNDPIDQRQRFEEQLKEREQGNDEAHEMDEDFLEALEYGMPPTGGLGIGV 468 Query: 552 DRVAMFLTDSNNIKEVLLFPAMK 574 DR+ M LT+S +I++VLLFP M+ Sbjct: 469 DRLVMLLTNSPSIRDVLLFPQMR 491 >4EX5-A nrPDB Length = 529 Score = 352 bits (904), Expect = 2e-97, Method: Compositional matrix adjust. Identities = 200/509 (39%), Positives = 280/509 (55%), Gaps = 13/509 (2%) Query: 70 SVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHL-QPGDHLTDITLKV 128 + D NQ R + L+ G YP+ F D Y+ + + + + Sbjct: 33 AADENQIVAERRDKLRALRDQG-IAYPNDFQPTHHAADLQTAYADADKEALEAKSLEVAI 91 Query: 129 AGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNP 188 AGR+ KR G K F ++ ++Q + +E K GDI+ +G Sbjct: 92 AGRMMLKRVMG-KASFATVQDGSGQIQFFVTPADVGAET--YDAFKKWDLGDIVAARGVL 148 Query: 189 GKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRS 248 +T KGELS+ ++ LL+ L LP GL D+ETRYRQRY+DLI+ R F R+ Sbjct: 149 FRTNKGELSVKCTQLRLLAKALRPLPDKFHGLADQETRYRQRYVDLIVTPETRTTFRART 208 Query: 249 KIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLV 308 K I IR F+ + F+E+ETPM++ IPGGA AKPF+T+HN LDM +++RIAPELY K L+ Sbjct: 209 KAIASIRKFMGDADFMEVETPMLHPIPGGAAAKPFVTHHNALDMEMFLRIAPELYLKRLI 268 Query: 309 VGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGS 368 VGG +RV+EI R FRNEG+ HNPEFT EFY AY DY LM+ TE+++ G+ Sbjct: 269 VGGFERVFEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDFTERLIRQAAVDALGT 328 Query: 369 YKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICV 428 + Y Q ++D PF R+ + + ++K + L + R L + V Sbjct: 329 ATIQY-------QGRELDLAQPFHRLTITQAIQK-YAPSYTDGQLSDDAFLRSELKRLGV 380 Query: 429 AKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFEL 488 L L E E PTFI D+P +SPLA+ + G+TERFEL Sbjct: 381 DVTQPAFLNAGIGALQLALFEETAEAQLWEPTFIIDYPIEVSPLARESDTVAGITERFEL 440 Query: 489 FVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWG 548 F+ +EI N ++ELNDP Q F++Q + K AGD+EAMF D ++ ALEYG+PPT G G Sbjct: 441 FITGREIANGFSELNDPEDQAARFKKQVEQKDAGDEEAMFFDADYIRALEYGMPPTGGCG 500 Query: 549 MGIDRVAMFLTDSNNIKEVLLFPAMKPED 577 +GIDR+ M LTDS I++VLLFP ++ ED Sbjct: 501 IGIDRLVMLLTDSPTIRDVLLFPHLRRED 529 >6NRZ-A nrPDB Length = 534 Score = 330 bits (846), Expect = 1e-90, Method: Compositional matrix adjust. Identities = 206/527 (39%), Positives = 299/527 (56%), Gaps = 35/527 (6%) Query: 77 YKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDI-----TLKVAGR 131 Y R+ + +++ G +PYP+++ + + + ++ + GD ++ AGR Sbjct: 21 YLYRTSKLKEIRDLGINPYPYQYTDCLEVQEIRNQFVDNELGDSEAAFRKETPKVRFAGR 80 Query: 132 IHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFI---------HINNKLRRGDII 182 + R S GK F + K+QVM N R++ + I KL GDI+ Sbjct: 81 LVLFR-SMGKNAFGQILDNDAKIQVMFN-RDFSAVAGLAADAGISPIKFIEKKLDLGDIL 138 Query: 183 GVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQ 242 G++G T GEL+++ +TLL L LP H GL DKE RYR+R+ DLI ++ VR+ Sbjct: 139 GLEGYLFFTHSGELTVLVETVTLLCKSLISLPDKHAGLADKEIRYRKRWADLISSEDVRK 198 Query: 243 KFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPEL 302 F+ RS+I+ IR ++D+ FLE+ETP++ + GGA A PF+T L +++RI+ E+ Sbjct: 199 TFLTRSRILKLIREYMDQQSFLEVETPILQTVYGGAEATPFVTTLQALHAEMFLRISLEI 258 Query: 303 YHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMV 362 K L+VGG+ RVYEIG+ FRNEGID THNPEFT E Y AY DY+D+M+ E +V +V Sbjct: 259 ALKKLLVGGMSRVYEIGKVFRNEGIDRTHNPEFTMIEAYAAYWDYNDVMKCVENLVEYIV 318 Query: 363 KHI-TGSYKVTYH--PDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEET 419 + + G +V Y GP+ VDF P+ R+ M E + G+ + +L E Sbjct: 319 RALNNGETQVQYSHLKSGPQV----VDFKAPWIRMTMKESISVYGGV---DVDLHADHEL 371 Query: 420 RKILD---DICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWH 476 RKIL+ + V A L D+LV + L I P I DHP +PL K Sbjct: 372 RKILETQTSLPEKTYVHASRGELIALLFDELVCDKL----IAPHHITDHPLETTPLCKTL 427 Query: 477 RS-KEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAG-DDEAMFIDENFC 534 RS E L ERFE F + KE+CNAY+ELNDP++QR+L EEQ + KA D E IDE F Sbjct: 428 RSGDETLVERFESFCLGKELCNAYSELNDPLQQRKLLEEQMRKKALNPDSEYHPIDEEFL 487 Query: 535 TALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKEN 581 AL G+PP G+G+GIDR+ M LTD+ +I++VL FP M+ + K++ Sbjct: 488 EALCQGMPPAGGFGIGIDRLVMMLTDAASIRDVLFFPVMRRIEAKKD 534 >6AQH-A nrPDB Length = 508 Score = 307 bits (786), Expect = 1e-83, Method: Compositional matrix adjust. Identities = 205/514 (39%), Positives = 286/514 (55%), Gaps = 26/514 (5%) Query: 69 ESVDPN--QYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITL 126 ESVDP+ + ++IR L G PYP +L + Q Y L P D T + Sbjct: 13 ESVDPDLPEQFRIRQAKRADLLAQGRQPYPVDVPRTHTLLEIRQAYPDL-PVDARTGEIV 71 Query: 127 KVAGRIHAKRASGGKLIFYDLR-GEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQ 185 V GR+ R S GKL F L+ G+G +LQ M S +E + + GDI+ V Sbjct: 72 GVTGRVVFARNS-GKLCFATLQEGDGTQLQAMI-SLAEVGQEALDNWKTYVDIGDIVFVH 129 Query: 186 GNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFI 245 G +K+GELS++ + + L LP H + + E+R RQRY+DLI+ D R+ Sbjct: 130 GEVITSKRGELSVLADSWQMAAKALRPLPVAHKEMSE-ESRVRQRYVDLIVRDQARKVAR 188 Query: 246 IRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHK 305 R ++ IRS L+ GFLE+ETPM+ + GGA A+PF+T+ N LD LY+RIAPEL+ K Sbjct: 189 QRIAVMRAIRSALERRGFLEVETPMLQTLAGGAAARPFVTHSNALDTELYLRIAPELFLK 248 Query: 306 MLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHI 365 +VGG +RV+E+ R FRNEG D TH+PEF E Y AY Y D +T +++ + Sbjct: 249 RCLVGGFERVFELNRVFRNEGADSTHSPEFVMLETYQAYGTYDDSAVVTRELIQEVADEA 308 Query: 366 TGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDD 425 G+ +V P+G YD+D + I M L +ALG ++ ET Sbjct: 309 IGTRQVPL----PDGTVYDLDGE--WESIQMYPSLSEALGEEITPDTPAETL-------- 354 Query: 426 ICVAKAVECPPPRTTARLLDKLVGEFLEVTC----INPTFICDHPQIMSPLAKWHRSKEG 481 +A + PR KLV E E T PTF+ D P +PL + HRS G Sbjct: 355 WAIADRLGLDIPRDRGYGHGKLVEELWEHTVGAKLWAPTFVKDFPVETTPLTRSHRSIPG 414 Query: 482 LTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGL 541 +TE+++L+V + E+ Y+EL DP+ QR+ FE QA+A AAGDDEAM +DE+F ALEYG+ Sbjct: 415 VTEKWDLYVRRIELATGYSELTDPIIQRERFEAQARAAAAGDDEAMALDEDFLAALEYGM 474 Query: 542 PPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKP 575 PP+ G GMGIDR+ M LT +I+E +LFP +KP Sbjct: 475 PPSTGTGMGIDRLMMTLT-GLSIRETVLFPIVKP 507 >6AQG-A nrPDB Length = 506 Score = 306 bits (785), Expect = 1e-83, Method: Compositional matrix adjust. Identities = 202/513 (39%), Positives = 290/513 (56%), Gaps = 28/513 (5%) Query: 69 ESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKV 128 ES P Q+ +IR +L G DPYP +L + Y+ L P D T+ + V Sbjct: 13 ESNIPEQF-RIRRDKRARLLAEGYDPYPVAIERTHTLAEIRATYADL-PTDSATEDIVGV 70 Query: 129 AGRIHAKRASGGKLIFYDLR-GEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGN 187 AGR+ R +G KL F L+ G+G +LQ M S + E + GD++ V G Sbjct: 71 AGRVVFARNTG-KLCFATLQDGDGTQLQAMI-SLDEVGRESLDRWKADVDIGDVVYVHGT 128 Query: 188 PGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIR 247 +++GELS++ + + L LP H + + E+R RQRY+DLI+ R+ R Sbjct: 129 VISSRRGELSVLADSWRMAAKALRPLPVAHKEMSE-ESRVRQRYVDLIVRPQAREVARQR 187 Query: 248 SKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKML 307 +I +R+ L+ GFLE+ETPM+ + GGA A+PF+T+ N LD++LY+RIAPEL+ K Sbjct: 188 IAVIRAVRNALERRGFLEVETPMLQTLAGGAAARPFVTHSNALDIDLYLRIAPELFLKRC 247 Query: 308 VVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITG 367 +VGG DRV+E+ R FRNEG D TH+PEF+ E Y Y Y D IT +++ + G Sbjct: 248 IVGGFDRVFELNRVFRNEGSDSTHSPEFSMLETYQTYGTYDDSALITRELIQEVADEAIG 307 Query: 368 SYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKL-PETNLFETEETRKILDDI 426 + +++ P+G YD+D + + M L +ALG ++ PET + L DI Sbjct: 308 TRQLSM----PDGSVYDID--GEWATMEMYSSLSEALGEQITPETTVAR-------LRDI 354 Query: 427 CVAKAVECPPPRTTARLLDKLVGEFLEVTCIN----PTFICDHPQIMSPLAKWHRSKEGL 482 VE + KLV E E N PTF+ D P +PL + HRS G+ Sbjct: 355 ASGLDVEID---NSVFGHGKLVEELWEHAVGNKLTAPTFVKDFPVETTPLTRQHRSIPGV 411 Query: 483 TERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLP 542 TE+++L+V E+ Y+ELNDP+ QR F +QA+A AAGDDEAM +DE+F TALEYG+P Sbjct: 412 TEKWDLYVRGVELATGYSELNDPVVQRDRFADQARAAAAGDDEAMQLDEDFLTALEYGMP 471 Query: 543 PTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKP 575 P G GMGIDR+ M LT +I+E +LFP ++P Sbjct: 472 PCTGTGMGIDRLLMCLT-GLSIRETVLFPIVRP 503 >3A5Z-A nrPDB Length = 328 Score = 126 bits (317), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 92/338 (27%), Positives = 152/338 (44%), Gaps = 50/338 (14%) Query: 247 RSKIITYIRSFLDELGFLEIETPMMN--------IIPGGAVAKPFITYHNELDMNLYMRI 298 R+ I+ IR F + G LE+ETP M+ ++P F+ + MNL++ Sbjct: 22 RAAIMAEIRRFFADRGVLEVETPCMSQATVTDIHLVP---FETRFVGPGHSQGMNLWLMT 78 Query: 299 APELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMV 358 +PE + K L+V G V+++ R FRNE + HNPEFT E+Y + D + LM + ++ Sbjct: 79 SPEYHMKRLLVAGCGPVFQLCRSFRNEEMGRYHNPEFTMLEWYRPHYDMYRLMNEVDDLL 138 Query: 359 SGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELE------KALGMKLPETN 412 ++ D P ++ + + F R ++ L + + KL +N Sbjct: 139 QQVL-------------DCPAAES--LSYQQAFLRYLEIDPLSADKTQLREVAAKLDLSN 183 Query: 413 LFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPL 472 + +TEE R L + VE P PTF+ P + L Sbjct: 184 VADTEEDRDTLLQLLFTFGVE---PNIGKE---------------KPTFVYHFPASQASL 225 Query: 473 AKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDEN 532 A+ + ERFE++ E+ N + EL D Q+Q FE+ + +AA ID+N Sbjct: 226 AQISTEDHRVAERFEVYYKGIELANGFHELTDAREQQQRFEQDNRKRAARGLPQHPIDQN 285 Query: 533 FCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLF 570 AL+ G+P +G +G+DR+ M + + EV+ F Sbjct: 286 LIEALKVGMPDCSGVALGVDRLVMLALGAETLAEVIAF 323 >3G1Z-A nrPDB Length = 326 Score = 122 bits (305), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 91/338 (26%), Positives = 148/338 (43%), Gaps = 50/338 (14%) Query: 247 RSKIITYIRSFLDELGFLEIETPMMN--------IIPGGAVAKPFITYHNELDMNLYMRI 298 R+ I+ IR F + G LE+ETP M+ + P F+ + +NLY+ Sbjct: 20 RAAIMAEIRRFFADRGVLEVETPCMSQATVTDIHLFP---FETRFVGPGHSQGINLYLMT 76 Query: 299 APELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMV 358 +PE + K L+ G V+++ R FRNE + HNPEFT E+Y + D + LM + ++ Sbjct: 77 SPEYHMKRLLAAGCGPVFQLCRSFRNEEMGRHHNPEFTMLEWYRPHYDMYRLMNEVDDLL 136 Query: 359 SGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELE------KALGMKLPETN 412 ++ P A + + F+R ++ L + KL +N Sbjct: 137 QQVLD---------CQP------AESLSYQQAFQRHLEIDPLSADKTQLREAAAKLDLSN 181 Query: 413 LFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPL 472 + +TEE R L + VE + PTFI P + L Sbjct: 182 IADTEEDRDTLLQLLFTMGVEP------------------HIGKEKPTFIYHFPASQASL 223 Query: 473 AKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDEN 532 A+ + ERFE++ E+ N + EL D Q+Q FE+ + +AA ID+N Sbjct: 224 AQISTEDHRVAERFEVYYKGIELANGFHELTDAREQQQRFEQDNRKRAARGLPQQPIDQN 283 Query: 533 FCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLF 570 AL GLP +G +G+DR+ M + ++ +V+ F Sbjct: 284 LLDALAAGLPDCSGVALGVDRLVMLALGAESLADVIAF 321 >1WYD-A nrPDB Length = 429 Score = 117 bits (293), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 135/460 (29%), Positives = 212/460 (46%), Gaps = 77/460 (16%) Query: 129 AGRIHAKRASGGK--LIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQG 186 AG +H R GGK +I D G G ++ V NS + I+ +L + +I V+G Sbjct: 22 AGWVHLLRDLGGKKFIILRDKTGLG-QVVVDKNSSAF-------GISQELTQESVIQVRG 73 Query: 187 NPGKTKKGELSIIPY--EITLLSPCLHMLPHLHFGL--KDKETRYRQRYLDLILNDFVRQ 242 K+ I + EITLLS LP G D +TR R+R LDL + ++ Sbjct: 74 IVKADKRAPRGIELHAEEITLLSKAKAPLPLDVSGKVKADIDTRLRERVLDLRRQE-MQA 132 Query: 243 KFIIRSKIITYIRSFLDELGFLEIETP--MMNIIPGGAVAKPFITYHNELDMNLYMRIAP 300 I+S + R L + GF+EI TP + + GGA P I + E ++ +P Sbjct: 133 VIKIQSLALKAFRETLYKEGFIEIFTPKIIASATEGGAQLFPVIYFGKEA----FLAQSP 188 Query: 301 ELYHKMLVVGGIDRVYEIGRQFRNEGIDLT-HNPEFTTCEFYMAYADYHDLMEITEKMVS 359 +LY K L+ G ++RV+E+ +R E D H EF + + MA+ADY+D+M++ EK++ Sbjct: 189 QLY-KELMAGVVERVFEVAPAWRAEESDTPFHLAEFISMDVEMAFADYNDVMQLLEKILH 247 Query: 360 GMVKHITGSYK-----VTYHPDGPEGQAYDVDFTPPFRRINMVEELE--KALGMKLPETN 412 +VK I K + Y P PE + P +R+ E +E ++ G + Sbjct: 248 NIVKTIKEEGKEELKILNYEP--PEVKI-------PIKRLKYTEAIEILRSKGYNI---- 294 Query: 413 LFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPL 472 K DDI + R+L++ + E L FI D P P Sbjct: 295 --------KFGDDIGTPE----------LRILNEELKEDL-------YFIVDWPSDARPF 329 Query: 473 AKWHRSKEG-LTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDE 531 +S+ L+E F+L EI + T + +R++ EE K K + F Sbjct: 330 YTKSKSENPELSESFDLIYKFLEIVSGSTRNH----KREVLEEALKKKGLKPESFEF--- 382 Query: 532 NFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 F +YG+PP AG+GMG+ R+ + LT ++KE++ FP Sbjct: 383 -FLKWFDYGMPPHAGFGMGLARLMVMLTGIQSVKEIVPFP 421 >3NEM-A nrPDB Length = 438 Score = 101 bits (252), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 124/463 (26%), Positives = 207/463 (44%), Gaps = 54/463 (11%) Query: 119 DHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRR 178 + L +KVAG + + GG + F +R +Q+ A + K + E + KLR Sbjct: 12 EELNGQKVKVAGWVWEVKDLGG-IKFLWIRDRDGIVQITAPKK--KVDPELFKLIPKLRS 68 Query: 179 GDIIGVQGNPGKTKKGELS--IIPYEITLLSPCLHMLPHLHFGLKDKE--TRYRQRYLDL 234 D++ V+G T K +L I+P +I +L+ LP G E TR R++DL Sbjct: 69 EDVVAVEGVVNFTPKAKLGFEILPEKIVVLNRAETPLPLDPTGKVKAELDTRLDNRFMDL 128 Query: 235 ILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETP--MMNIIPGGAVAKPFITYHNELDM 292 + V F IRS + +R F E GF+EI TP + GG P + Y E Sbjct: 129 RRPE-VMAIFKIRSSVFKAVRDFFHENGFIEIHTPKIIATATEGGTELFP-MKYFEE--- 183 Query: 293 NLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLT-HNPEFTTCEFYMAY-ADYHDL 350 + ++ +P+LY ++++ G+DRVYEI FR E + T H E + + MA+ D ++ Sbjct: 184 DAFLAQSPQLYKQIMMASGLDRVYEIAPIFRAEEHNTTRHLNEAWSIDSEMAFIEDEEEV 243 Query: 351 MEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPE 410 M E++V+ + ++ E A ++D +N ELE+ KLP Sbjct: 244 MSFLERLVAHAINYVR------------EHNAKELDI------LNF--ELEEP---KLPF 280 Query: 411 TNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPT-FICDHPQIM 469 + ++ +IL D+ E P ++L+G+++ P F+ +P Sbjct: 281 PRV-SYDKALEILGDL----GKEIPWGEDIDTEGERLLGKYMMENENAPLYFLYQYPSEA 335 Query: 470 SPLAKW-HRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMF 528 P + +K + F+L EI + + + EQ K K + F Sbjct: 336 KPFYIMKYDNKPEICRAFDLEYRGVEISSG----GQREHRHDILVEQIKEKGLNPESFEF 391 Query: 529 IDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 + A YG+PP G+G+G +R+ + D NI+EV+LFP Sbjct: 392 ----YLKAFRYGMPPHGGFGLGAERLIKQMLDLPNIREVILFP 430 >4WJ3-M nrPDB Length = 599 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 76/255 (29%), Positives = 130/255 (50%), Gaps = 26/255 (10%) Query: 126 LKVAGRIHAKRASGGKLIFYDLRG-EGV--------KLQVMANSRNYKSEEEFIHINNKL 176 + + G +H +R GG +IF D+R EG+ + + A + +SE + I K+ Sbjct: 27 VTLCGWVHRRRDHGG-VIFLDVRDREGLAQVVFDPDRAETFAKADRVRSEF-VVKITGKV 84 Query: 177 RRGDIIGVQG--NPGKTKKGELSIIPYEITLLSPC-LHMLPHLHFGLKDKETRYRQRYLD 233 R + +G NP G + ++ YE+ +L+ P + +ETR R R++D Sbjct: 85 R----LRPEGARNP-NMASGSIEVLGYELEVLNQAETPPFPLDEYSDVGEETRLRYRFID 139 Query: 234 LILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMN-IIPGGA--VAKPFITYHNEL 290 L + K +R++I + IR +LD+ GFL++ETP++ P GA P TY Sbjct: 140 LRRPEMA-AKLKLRARITSSIRRYLDDNGFLDVETPILGRPTPEGARDYLVPSRTYPGHF 198 Query: 291 DMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDL 350 + +P+L+ ++L+V G DR Y+I + FR+E + PEFT + ++ D D+ Sbjct: 199 ---FALPQSPQLFKQLLMVAGFDRYYQIAKCFRDEDLRADRQPEFTQIDIETSFLDESDI 255 Query: 351 MEITEKMVSGMVKHI 365 + ITEKMV + K + Sbjct: 256 IGITEKMVRQLFKEV 270 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 24/91 (26%), Positives = 48/91 (52%), Gaps = 4/91 (4%) Query: 481 GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG 540 L+ +++ + E+ ++D Q+ +F +A +++ F+ AL+YG Sbjct: 478 ALSRAYDMVLNGTELGGGSIRIHDKSMQQAVFRVLGIDEAEQEEKFGFL----LDALKYG 533 Query: 541 LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 PP G G+DR+ M +T +++I+EV+ FP Sbjct: 534 APPHGGLAFGLDRLVMLMTGASSIREVIAFP 564 >5W25-A nrPDB Length = 616 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 74/257 (28%), Positives = 124/257 (48%), Gaps = 23/257 (8%) Query: 115 LQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINN 174 L+ GD +TL AG + +R GG +IF DLR QV+ + E + + Sbjct: 32 LREGDAGQQVTL--AGWVARRRDHGG-VIFIDLRDASGIAQVVFRD---PQDTEVLAQAH 85 Query: 175 KLRRGDIIGVQG----------NPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKE 224 +LR + V G NP + GE+ + +T+L C LP +E Sbjct: 86 RLRAEFCVSVAGVVEIRPEGNANP-EIATGEIEVNATSLTVLGECAP-LPFQLDEPAGEE 143 Query: 225 TRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMN-IIPGGAVAKPF 283 R + RYLDL +D +RS++ R+ L F+EIETP + P GA + F Sbjct: 144 LRLKYRYLDLRRDDPA-AAIRLRSRVNAAARAVLARHDFVEIETPTITRSTPEGA--RDF 200 Query: 284 ITYHNELDMNLY-MRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYM 342 + + Y + +P+L+ ++L+V G++R Y+I R +R+E PEFT + M Sbjct: 201 LVPARLHPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDMEM 260 Query: 343 AYADYHDLMEITEKMVS 359 ++ D D++ I+E++++ Sbjct: 261 SFVDAEDIIAISEEVLT 277 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 29/124 (23%), Positives = 50/124 (40%), Gaps = 9/124 (7%) Query: 453 EVTCINPTFICDHPQIMSPLAKWHRSKEG-----LTERFELFVMKKEICNAYTELNDPMR 507 EV + + H +P +W E L + +++ EI ++ Sbjct: 461 EVAVGSGAWTAVHHAFTAPKPEWEDRIESDTGSVLADAYDIVCNGHEIGGGSVRIHRRDI 520 Query: 508 QRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEV 567 Q ++F KA +++ F+ E F +G PP G G DR L ++I+EV Sbjct: 521 QERVFAVMGLDKAEAEEKFGFLLEAFM----FGAPPHGGIAFGWDRTTALLAGMDSIREV 576 Query: 568 LLFP 571 + FP Sbjct: 577 IAFP 580 >1IL2-A nrPDB Length = 590 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 67/243 (27%), Positives = 119/243 (48%), Gaps = 17/243 (6%) Query: 135 KRASGGKLIFYDLRGEGVKLQVM-----ANSRNYKSE--EEF-IHINNKLRRGDIIGVQG 186 +R G LIF D+R +QV A++ SE EF I + +R D + Sbjct: 26 RRRDLGSLIFIDMRDREGIVQVFFDPDRADALKLASELRNEFCIQVTGTVRARDEKNINR 85 Query: 187 NPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFII 246 + GE+ ++ +T+++ +LP + +E R + RYLDL + Q+ Sbjct: 86 D---MATGEIEVLASSLTIINRA-DVLPLDSNHVNTEEARLKYRYLDLRRPEMA-QRLKT 140 Query: 247 RSKIITYIRSFLDELGFLEIETPMMN-IIPGGAVAKPFITYHNELDMNLY-MRIAPELYH 304 R+KI + +R F+D+ GFL+IETPM+ P GA + ++ Y + +P+L+ Sbjct: 141 RAKITSLVRRFMDDHGFLDIETPMLTKATPEGA--RDYLVPSRVHKGKFYALPQSPQLFK 198 Query: 305 KMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKH 364 ++L++ G DR Y+I + FR+E + PEFT + ++ + E+ E +V + Sbjct: 199 QLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMTAPQVREVMEALVRHLWLE 258 Query: 365 ITG 367 + G Sbjct: 259 VKG 261 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 19/36 (52%), Positives = 27/36 (75%) Query: 536 ALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 AL+YG PP AG G+DR+ M LT ++NI++V+ FP Sbjct: 520 ALKYGTPPHAGLAFGLDRLTMLLTGTDNIRDVIAFP 555 >4J15-A nrPDB Length = 521 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 109/476 (22%), Positives = 196/476 (41%), Gaps = 64/476 (13%) Query: 122 TDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDI 181 D + V R+H RA G K F LR + +Q + ++ S++ + + + I Sbjct: 76 ADEVVWVRARVHTSRAKG-KQCFLVLRQQQFNVQALVAVGDHASKQ-MVKFAANINKESI 133 Query: 182 IGVQGNPGKTKKGELSIIPYEITLLSPCLHML----PHLHFGLKD--------------- 222 + V+G K + S ++ L ++++ P L L D Sbjct: 134 VDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRAT 193 Query: 223 --KETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVA 280 ++TR R +DL + + F ++S I R L GF+EI+TP II + Sbjct: 194 VNQDTRLDNRVIDLRTST-SQAVFRLQSGICHLFRETLINKGFVEIQTP--KIISAASEG 250 Query: 281 KPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDL-THNPEFTTCE 339 + + N Y+ +P+LY +M + ++V+ IG FR E + H EF + Sbjct: 251 GANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLD 310 Query: 340 FYMAYA-DYHDLME-ITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMV 397 MA+ YH++ME I + MV + K + ++ + F P R+ Sbjct: 311 IEMAFNYHYHEVMEEIADTMVQ-IFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYC 369 Query: 398 EELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCI 457 E AL M L E + +E DD+ +KL+G ++ Sbjct: 370 E----ALAM-LREAGVEMGDE-----DDLSTPN--------------EKLLGHLVKEKYD 405 Query: 458 NPTFICD-HPQIMSPLAKWHRSKE-GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQ 515 +I D +P + P + + +++F+ +EI + ++DP QL E+ Sbjct: 406 TDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDP----QLLTER 461 Query: 516 AKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 A D E + + + + +G PP AG G+G++RV M +N+++ +FP Sbjct: 462 ALHHGI-DLEKI---KAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 513 >4RMF-A nrPDB Length = 609 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 75/263 (28%), Positives = 125/263 (47%), Gaps = 26/263 (9%) Query: 115 LQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINN 174 L+P D +TL AG + +R GG +IF DLR QV+ E + + + Sbjct: 10 LRPADAGQTVTL--AGWVARRRDHGG-VIFIDLRDASGVSQVVFR------EGDVLAAAH 60 Query: 175 KLRRGDIIGVQG----------NPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKE 224 +LR + V G NP + G++ + E+T+L LP +E Sbjct: 61 RLRAEFCVAVTGVVEVRPEGNENP-EIPTGQIEVNATELTVLGESAP-LPFQLDEQAGEE 118 Query: 225 TRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMN-IIPGGAVAKPF 283 R + RYLDL + +RSK+ RS L E F+EIETP + P GA + F Sbjct: 119 ARLKYRYLDL-RREGPGNALRLRSKVNAAARSVLAEHDFVEIETPTLTRSTPEGA--RDF 175 Query: 284 ITYHNELDMNLY-MRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYM 342 + + Y + +P+L+ ++L+V G++R Y+I R +R+E PEFT + M Sbjct: 176 LVPARLQPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDMEM 235 Query: 343 AYADYHDLMEITEKMVSGMVKHI 365 ++ + D++ I+E+++ + I Sbjct: 236 SFVEADDVIAISEQVLKAVWATI 258 Score = 37.7 bits (86), Expect = 0.014, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 20/36 (55%) Query: 536 ALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 A YG PP G G DR+ L ++I+EV+ FP Sbjct: 520 AFSYGAPPHGGIAFGWDRITALLAGVDSIREVIAFP 555 >1EFW-A nrPDB Length = 580 Score = 80.9 bits (198), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 46/198 (23%), Positives = 94/198 (47%), Gaps = 25/198 (12%) Query: 246 IRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHK 305 +R ++I I FLD GF+++ETP + + Y +E + + +P+L+ + Sbjct: 146 LRHRVIKAIWDFLDREGFVQVETPFLTKSTPEGARDFLVPYRHEPGLFYALPQSPQLFKQ 205 Query: 306 MLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHI 365 ML+V G+DR ++I R FR+E + P+FT + M++ + D++E+ E++++ + + Sbjct: 206 MLMVAGLDRYFQIARCFRDEDLRADRQPDFTQLDLEMSFVEVEDVLELNERLMAHVFR-- 263 Query: 366 TGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEK--------ALGMKLPETNLFETE 417 +A V+ PF R++ E +E+ G++L E + Sbjct: 264 ---------------EALGVELPLPFPRLSYEEAMERYGSDKPDLRFGLELKEVGPLFRQ 308 Query: 418 ETRKILDDICVAKAVECP 435 ++ + KA+ P Sbjct: 309 SGFRVFQEAESVKALALP 326 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 35/120 (29%), Positives = 56/120 (46%), Gaps = 6/120 (5%) Query: 455 TCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEE 514 T ++ F HP+ + L K L ++L + E+ ++DP Q ++F Sbjct: 439 TYMHHPFTSPHPEDLPLLEKDPGRVRALA--YDLVLNGVEVGGGSIRIHDPRLQARVF-- 494 Query: 515 QAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMK 574 + G++E F ALEYG PP G G+DR+ +T S +I+EV+ FP K Sbjct: 495 --RLLGIGEEEQREKFGFFLEALEYGAPPHGGIAWGLDRLLALMTGSPSIREVIAFPKNK 552 >1ASZ-A nrPDB Length = 490 Score = 80.1 bits (196), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 112/472 (23%), Positives = 189/472 (40%), Gaps = 65/472 (13%) Query: 130 GRIHAKRASGGKLIFYDLRGEGVKLQ--VMANSRNYKSEEEFIHINNKLRRGDIIGVQG- 186 R+H R G L F LR + +Q V AN S+ + L I+ V+G Sbjct: 46 ARVHNTRQQGATLAFLTLRQQASLIQGLVKANKEGTISKN-MVKWAGSLNLESIVLVRGI 104 Query: 187 -----NPGKTKKGE-LSIIPYEITLLSPCLHMLPHL--------------HFGLKDKETR 226 P K+ + L I +I +S LP L + + +TR Sbjct: 105 VKKVDEPIKSATVQNLEIHITKIYTISETPEALPILLEDASRSEAEAEAAGLPVVNLDTR 164 Query: 227 YRQRYLDL--ILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPF- 283 R +DL + N + F I++ + R +L F E+ TP + P + F Sbjct: 165 LDYRVIDLRTVTNQAI---FRIQAGVCELFREYLATKKFTEVHTPKLLGAPSEGGSSVFE 221 Query: 284 ITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDL-THNPEFTTCEFYM 342 +TY Y+ +P+ + L+V +RVYEIG FR E + H EFT + M Sbjct: 222 VTY---FKGKAYLAQSPQFNKQQLIVADFERVYEIGPVFRAENSNTHRHMTEFTGLDMEM 278 Query: 343 AYAD-YHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELE 401 A+ + YH++++ ++ + + P+ A++++ R+ VEE Sbjct: 279 AFEEHYHEVLDTLSELFVFIFSEL------------PKRFAHEIELV---RKQYPVEEF- 322 Query: 402 KALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTF 461 KLP+ T K ++ A E + +K +G+ + + Sbjct: 323 -----KLPKDGKM-VRLTYKEGIEMLRAAGKEIGDFEDLSTENEKFLGKLVRDKYDTDFY 376 Query: 462 ICDH-PQIMSPLAKW-HRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAK 519 I D P + P + + ++ F+ +EI + ++D L +E+ KA Sbjct: 377 ILDKFPLEIRPFYTMPDPANPKYSNSYDFFMRGEEILSGAQRIHD----HALLQERMKAH 432 Query: 520 AAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 ++ D +C YG PP AG G+G++RV MF D NI+ LFP Sbjct: 433 GLSPEDPGLKD--YCDGFSYGCPPHAGGGIGLERVVMFYLDLKNIRRASLFP 482 >6OD8-A nrPDB Length = 558 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 109/494 (22%), Positives = 201/494 (40%), Gaps = 70/494 (14%) Query: 121 LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD 180 L D T+ + R+ R G K+ F LR +Q MA +E I ++ Sbjct: 84 LVDKTVLIRARVSTTRKKG-KMAFMVLRDGSDSVQAMAAVEG-DVPKEMIDFMGQIATES 141 Query: 181 IIGVQGNPGKTKKGELSIIPYEITLLSPCLHM----LPHLHFGLKDK------------- 223 I+ V+ K ++ S +I L +H L L F L+D Sbjct: 142 IVDVEATVCKVEQPITSTSHSDIELKVKKIHTVTESLRTLPFTLEDASRKESAEGAKVNL 201 Query: 224 ETRYRQRYLDL--ILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAK 281 +TR R++DL + + + F ++S++ Y R FL + F EI +P + P A Sbjct: 202 DTRLNSRWMDLRTLASGAI---FRLQSRVCQYFRQFLIDKDFCEIHSPKIINAPSEGGAN 258 Query: 282 PF-ITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDL-THNPEFTTCE 339 F + Y N Y+ +P+LY +M++ G + RV+E+G FR+E + H EF + Sbjct: 259 VFKLEYFNRF---AYLAQSPQLYKQMVLQGDVPRVFEVGPVFRSENSNTHRHLTEFVGLD 315 Query: 340 FYMAYAD-YHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVE 398 M + Y++++++ E + + + + ++ H + F P + + Sbjct: 316 VEMRIDEHYYEVLDVAESLFNYIFE------RLATHTKELKNVCQQYPFEPLVWK--LTP 367 Query: 399 ELEKALGMKLPETNLFETEETR-------------------KILDDICVAKAVECPPPRT 439 E K LG+ + + T++ + ++L+ + K T Sbjct: 368 ERIKELGVGVISEGVVPTDKFQARVHNMDSRMLRINYMHCIELLNTVLDEKMAPTDDINT 427 Query: 440 TARLLDKLVGEFLEVTCINPTFICDH-PQIMSPLAKWH-RSKEGLTERFELFVMKKEICN 497 T +KL+G+ ++ FI D P P + T +++F+ +EI + Sbjct: 428 TN---EKLLGKLVKERYGTDFFISDRFPSSARPFYTMECKDDVRFTNSYDMFIRGEEISS 484 Query: 498 AYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMF 557 ++DP L A+AK D + + + G P G+G+G++RV M Sbjct: 485 GAQRIHDP----DLL--LARAKMLNVDLTPI--KEYVDSFRLGAWPHGGFGIGLERVVML 536 Query: 558 LTDSNNIKEVLLFP 571 +N++ LFP Sbjct: 537 YLGLSNVRLASLFP 550 >4AH6-A nrPDB Length = 617 Score = 75.1 bits (183), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 56/178 (31%), Positives = 93/178 (52%), Gaps = 9/178 (5%) Query: 185 QGNPGKTKKGELSIIPYEITLLSPCLHMLPHL-HFGLKDKETRYRQRYLDLILNDFVRQ- 242 Q NP K GE+ I LL+ C + + +F K + R + RYLDL F Q Sbjct: 90 QENP-KMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEALRLQYRYLDL--RSFQMQY 146 Query: 243 KFIIRSKIITYIRSFLDEL-GFLEIETP-MMNIIPGGAVAKPFITYHNELDMNLYMRIAP 300 +RS+++ +R +L L GF++IETP + PGGA K F+ E + +P Sbjct: 147 NLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGA--KEFLVPSREPGKFYSLPQSP 204 Query: 301 ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMV 358 + + ++L+VGG+DR +++ R +R+EG PEFT + M++ D + + E ++ Sbjct: 205 QQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEGLL 262 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 29/111 (26%), Positives = 52/111 (46%), Gaps = 9/111 (8%) Query: 461 FICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKA 520 F HP + L + K+ ++ ++L + EI +++ QR + A Sbjct: 465 FTAPHPSDIHLL--YTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYIL-----ATL 517 Query: 521 AGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 +D M + AL+YG PP G +G+DR+ +T S +I++V+ FP Sbjct: 518 LKEDVKML--SHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFP 566 >3I7F-A nrPDB Length = 548 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 93/360 (25%), Positives = 152/360 (42%), Gaps = 54/360 (15%) Query: 223 KETRYRQRYLDL--ILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVA 280 ++TR R LDL + N + F I+S R FL F+EI TP +I + Sbjct: 224 QDTRLDNRMLDLRTVTNIAI---FRIQSACCGLFREFLTSQKFVEIHTP--KLIGCSSEG 278 Query: 281 KPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLT-HNPEFTTCE 339 I D Y+ +P+LY +M ++G +V+E+G FR E + H EF + Sbjct: 279 GSNIFEVKYFDRKAYLAQSPQLYKQMAIMGDFRKVFEVGPVFRAENSNTRRHLTEFEGLD 338 Query: 340 FYMAYA-DYHDLMEITEKMVSGMVKHITGSY----KVTYHPDGPEGQAYDVDFTPPFRRI 394 M +YH+ +++ EK+ + + I + KV E Y PF R+ Sbjct: 339 IEMEIVENYHECIDVMEKLFTFIFDEIPKRFPDELKVIRKQYPFEDLIYR-----PFLRL 393 Query: 395 NMVEELE--KALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFL 452 E +E +A G + + + F T + K L ++ AK T +LDK Sbjct: 394 TYKEAIEMLRASGETIGDYDDFTTPQEVK-LGELIKAKY------NTDFYILDKFPA--- 443 Query: 453 EVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDP-MRQRQL 511 I P + P I P + +++FV +EI + ++DP ++ Sbjct: 444 ---AIRPFYT--MPDIDDP---------NYSNSYDVFVRGQEITSGAQRIHDPEFLMKRC 489 Query: 512 FEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 E+ G D A D + + +G P AG G+G++R+ M NI++V LFP Sbjct: 490 IEK-------GVDPATLKD--YIESFRFGSWPHAGCGIGLERITMLYLGIPNIRKVTLFP 540 >1N9W-A nrPDB Length = 422 Score = 68.6 bits (166), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 99/456 (21%), Positives = 185/456 (40%), Gaps = 67/456 (14%) Query: 126 LKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQ 185 +++ G +H +R G++ F LR +QV+ E + + RG ++ Sbjct: 16 VELLGFLHWRR-DLGRIQFLLLRDRSGVVQVVTGGLKLPLPESALRV-----RGLVVENA 69 Query: 186 GNPGKTKKGELSIIPYEITLLSPCLHMLP---HLHFGLKDKETRYRQRYLDLILNDFVRQ 242 PG L + E+ +LSP L P + +T RY+ L + R Sbjct: 70 KAPGG-----LEVQAKEVEVLSPALEPTPVEIPKEEWRANPDTLLEYRYVTL-RGEKARA 123 Query: 243 KFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPEL 302 +++ ++ R +LD F EI TP ++ GA + + + Y+ +P+L Sbjct: 124 PLKVQAALVRGFRRYLDRQDFTEIFTP--KVVRAGAEGGSGLFGVDYFEKRAYLAQSPQL 181 Query: 303 YHKMLVVGGIDRVYEIGRQFRNEGIDLT-HNPEFTTCEFYMAY-ADYHDLMEITEKMVSG 360 Y K ++VG +RVYE+ +R E + H E+ + + M + AD DLM + E +++ Sbjct: 182 Y-KQIMVGVFERVYEVAPVWRMEEHHTSRHLNEYLSLDVEMGFIADEEDLMRLEEALLAE 240 Query: 361 MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLP----ETNLFET 416 M++ +N + + LG P + Sbjct: 241 MLEEA----------------------------LNTAGDEIRLLGATWPSFPQDIPRLTH 272 Query: 417 EETRKILDDICVAKAVECPPPRTTARLLDKLVGEFL-EVTCINPTFICDHPQIMSPLAKW 475 E ++IL + + P + + ++L+GE+ E + F+ +P+ + P + Sbjct: 273 AEAKRILKE-----ELGYPVGQDLSEEAERLLGEYAKERWGSDWLFVTRYPRSVRPFYTY 327 Query: 476 HRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCT 535 ++G T F+L EI + ++ R +L E KA G D F + Sbjct: 328 P-EEDGTTRSFDLLFRGLEITSGGQRIH---RYEELLE---SLKAKGMDPEAF--HGYLE 378 Query: 536 ALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 +YG+PP G+ +G +R+ L N++ FP Sbjct: 379 VFKYGMPPHGGFAIGAERLTQKLLGLPNVRYARAFP 414 >5XIX-A nrPDB Length = 472 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 104/465 (22%), Positives = 177/465 (38%), Gaps = 71/465 (15%) Query: 126 LKVAGRIHAKRASGGKLIFYDLR-GEGVKLQVMANSRNYKSEEEFIHINNK--LRRGDII 182 +KV G +H R G L+F LR G G V+A+ E N L + Sbjct: 52 VKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLAD--------ELCQCYNGVLLSTESSV 103 Query: 183 GVQGNPGKTKKG-------ELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLI 235 V G T KG ELS +E+ L+P +L D + + R++ +I Sbjct: 104 AVYGMLNLTPKGKQAPGGHELSCDFWELIGLAPA-GGADNLINEESDVDVQLNNRHM-MI 161 Query: 236 LNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMM--NIIPGGAVAKPFITYHNELDMN 293 + + + RS + R + G+ E+ P + + GGA + E Sbjct: 162 RGENMSKILKARSMVTRCFRDHFFDRGYYEVTPPTLVQTQVEGGATLFKLDYFGEEA--- 218 Query: 294 LYMRIAPELYHKMLVVGGIDRVYEIGRQFRNE-GIDLTHNPEFTTCEFYMAYADYHDLME 352 ++ + +LY + + + V+ I + +R E H E+T E + + DL+ Sbjct: 219 -FLTQSSQLYLET-CLPALGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFLTFDDLLN 276 Query: 353 ITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTP---PFRRINMVEELE--KALGMK 407 E +V +V I S P G + +F P PF+R+N + + K +K Sbjct: 277 RLEDLVCDVVDRILKS------PAGSIVHELNPNFQPPKRPFKRMNYSDAIVWLKEHDVK 330 Query: 408 LPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHP- 466 + +E E DI P RL+ + E P +C P Sbjct: 331 KEDGTFYEFGE------DI----------PEAPERLMTDTINE--------PILLCRFPV 366 Query: 467 QIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEA 526 +I S + LTE ++ + N + MR E A K G D Sbjct: 367 EIKSFYMQRCPEDSRLTESVDVLMP-----NVGEIVGGSMRIFDSEEILAGYKREGIDPT 421 Query: 527 MFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 + + +YG P G+G+G++R ++ + +I++V L+P Sbjct: 422 PYY--WYTDQRKYGTCPHGGYGLGLERFLTWILNRYHIRDVCLYP 464 >3P8T-A nrPDB Length = 294 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 73/344 (21%), Positives = 138/344 (40%), Gaps = 93/344 (27%) Query: 246 IRSKIITYIRSFLDELGFLEIETPMMNII-------PGGAVAKPFITYHNELDM-NLYMR 297 I++KI+ Y+ F + GF + M++ I P G +P E+D+ + MR Sbjct: 17 IQTKILDYMTKFFTDRGFKWLLPIMLSPITDPLWPDPAGEGIRP-----AEVDVYGVRMR 71 Query: 298 IAPEL-YHKMLVVG-GIDRVYEIGRQFRNEGI---DLTHNPEFTTCEFYMAYADYHDLME 352 + + HK L + G+++++ + R E D H+ EFT +F + A D+M Sbjct: 72 LTHSMILHKQLAIAMGLEKIFVLSPNIRLESRRKDDGRHSYEFTQLDFEIEGAKMKDVMR 131 Query: 353 ITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETN 412 + E+++ G+ FR+ E+ G + P Sbjct: 132 LIEELIYGL-----------------------------FRK------AEEWTGREFPRAR 156 Query: 413 LFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPL 472 F+ + + IL++ E + P +I + P+ Sbjct: 157 HFKVYDYKDILEEFG--------------------SDEKASMEMEEPFWIVNIPREF--- 193 Query: 473 AKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEE-QAKAKAAGDDEAMFIDE 531 + R + G+ + ++L + Y E++ + +E+ AK +AAG E + Sbjct: 194 --YDREENGVWKNYDLI-----LPYGYGEVSSGGEREWEYEKIVAKIRAAGLKE-----D 241 Query: 532 NFCTALEYG----LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 +F LE L P+AG G+G++R+ F+ + +I EV FP Sbjct: 242 SFRPYLEIARAGKLKPSAGAGIGVERLVRFIVGAKHIAEVQPFP 285 >1X54-A nrPDB Length = 434 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 69/347 (19%), Positives = 130/347 (37%), Gaps = 78/347 (22%) Query: 246 IRSKIITYIRSFLDELGFLEIETPMM--NIIPGGAVAKPFITYHNELDMNLYMRIAPELY 303 ++ +I R +L + G+ E+ P++ + GGA + D Y+ + +LY Sbjct: 137 VKETLIMAAREWLLKDGWHEVFPPILVTGAVEGGAT----LFKLKYFDKYAYLSQSAQLY 192 Query: 304 HKMLVVGGIDRVYEIGRQFRNE-GIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMV 362 + + G +++V+ + FR E H EF E A+ D D+M++ E++VS MV Sbjct: 193 LEAAIFG-LEKVWSLTPSFRAEKSRTRRHLTEFWHLELEAAWMDLWDIMKVEEELVSYMV 251 Query: 363 KHITGSYKVTYHPDGPEGQAYDVDFT------PPFRRINMVEELEKALGMKLPETNLFET 416 + T E + + D T PPF RI+ E + Sbjct: 252 QR-------TLELRKKEIEMFRDDLTTLKNTEPPFPRISYDEAI---------------- 288 Query: 417 EETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWH 476 DI +K V ++++ E + P F+ +P+ Sbjct: 289 --------DILQSKGVNVEWGDDLGADEERVLTEEFD----RPFFVYGYPK--------- 327 Query: 477 RSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFID------ 530 + F MK++ + L M + + E DD ++ Sbjct: 328 --------HIKAFYMKEDPNDPRKVLASDMLAPEGYGEIIGGSQREDDYDKLLNRILEEG 379 Query: 531 ------ENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 E + YG P +G+G+G++R+ ++ ++I+ LFP Sbjct: 380 MDPKDYEWYLDLRRYGSVPHSGFGLGVERLVAWVLKLDHIRWAALFP 426 >1NNH-A nrPDB Length = 294 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 72/339 (21%), Positives = 134/339 (39%), Gaps = 83/339 (24%) Query: 246 IRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLY---MRIAPEL 302 I++KI+ Y+ F + GF + +++ I P ++ +Y MR+ + Sbjct: 17 IQTKILEYMTDFFVKEGFKWLLPVIISPITDPLWPDPAGEGMEPAEVEIYGVKMRLTHSM 76 Query: 303 -YHKMLVVG-GIDRVYEIGRQFRNEGI---DLTHNPEFTTCEFYMAYADYHDLMEITEKM 357 HK L + G+ +++ + R E D H EFT +F + A D+M + E++ Sbjct: 77 ILHKQLAIAMGLKKIFVLSPNIRLESRQKDDGRHAYEFTQLDFEVERAKMEDIMRLIERL 136 Query: 358 VSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETE 417 V G+ FR+ E+ G + P+T FE Sbjct: 137 VYGL-----------------------------FRK------AEEWTGREFPKTKRFEVF 161 Query: 418 ETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHR 477 E ++L++ D+ + +E P +I + P+ + R Sbjct: 162 EYSEVLEEFGS----------------DEKASQEME----EPFWIINIPREF-----YDR 196 Query: 478 SKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEE-QAKAKAAGDDEAMFIDENFCTA 536 +G ++L + Y E+ + +E+ AK + AG +E ++F Sbjct: 197 EVDGFWRNYDLI-----LPYGYGEVASGGEREWEYEKIVAKIRKAGLNE-----DSFRPY 246 Query: 537 LEYG----LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 LE L P+AG G+G++R+ F+ + +I EV FP Sbjct: 247 LEIAKAGKLKPSAGAGIGVERLVRFIVGAKHIAEVQPFP 285 >2XGT-A nrPDB Length = 435 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 14/33 (42%), Positives = 25/33 (75%) Query: 539 YGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 YG P G+G+G++R +LT++N+I++V L+P Sbjct: 395 YGTCPHGGYGLGLERFICWLTNTNHIRDVCLYP 427 >3M4P-A nrPDB Length = 456 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 74/351 (21%), Positives = 144/351 (41%), Gaps = 61/351 (17%) Query: 234 LILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMM--NIIPGGAVAKPFITYHNELD 291 +I ++ +Q +RS+I Y R + + F EI+ P + GG+ + Y NE Sbjct: 146 VIRSEHTQQVLQLRSEIQWYFRKYYHDNHFTEIQPPTIVKTQCEGGSTLFK-LQYFNE-- 202 Query: 292 MNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNE-GIDLTHNPEFTTCEFYMAYADYHDL 350 Y+ + +LY + V+ + + + + +R E + H E+ E + + + DL Sbjct: 203 -PAYLTQSSQLYLES-VIASLGKSFCMLSSYRAEQSRTVRHLAEYLHLEAELPFISFEDL 260 Query: 351 MEITEKMVSGMVKHITGSY-----KVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALG 405 + E +V ++ ++ + K+ H P T PF+R+ + ++ Sbjct: 261 LNHLEDLVCTVIDNVMAVHGDKIRKMNPHLKLP---------TRPFKRMTYADAIKYC-- 309 Query: 406 MKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDH 465 + + ++ + +DI E P + T E+ C P F+ Sbjct: 310 ---NDHGILNKDKPFEYGEDIS-----EKPERQMTD-----------EIGC--PIFMIHF 348 Query: 466 PQIMSPLAKWHRSK----EGLTERFELFVMK-KEICNAYTELNDPMRQRQLFEEQAKAKA 520 P S + ++ SK LTE +L + EI + MR E KA Sbjct: 349 P---SKMKAFYMSKVPGHPDLTESVDLLMPGVGEI------VGGSMRIWNYDELMGAYKA 399 Query: 521 AGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 G + + + +YG P G+G+G++R+ M+L ++I++V L+P Sbjct: 400 NGLNPDPYY--WYTQQRKYGSCPHGGYGLGVERLVMWLLGEDHIRKVCLYP 448 >3VQX-A nrPDB Length = 291 Score = 34.3 bits (77), Expect = 0.15, Method: Compositional matrix adjust. Identities = 39/148 (26%), Positives = 62/148 (41%), Gaps = 23/148 (15%) Query: 254 IRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNEL-------DMNLYMR--IAPELYH 304 I F + GFLEI++P++ IP + + I EL D N +R +AP LY+ Sbjct: 87 ITRFFVDRGFLEIKSPIL--IPLEYIERMGIDNDTELSKQIFRVDKNFCLRPMLAPNLYN 144 Query: 305 KMLVVGGIDR-------VYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKM 357 + +DR ++EIG +R E H EFT F + E E + Sbjct: 145 ---YLRKLDRALPDPIKIFEIGPCYRKESDGKEHLEEFTMLNFCQMGSGCT--RENLESI 199 Query: 358 VSGMVKHITGSYKVTYHPDGPEGQAYDV 385 ++ + H+ +K+ G DV Sbjct: 200 ITDFLNHLGIDFKIVGDSCMVYGDTLDV 227 >2W57-A nrPDB Length = 150 Score = 32.3 bits (72), Expect = 0.60, Method: Compositional matrix adjust. Identities = 23/85 (27%), Positives = 39/85 (45%), Gaps = 12/85 (14%) Query: 299 APELYHKMLVVG---GIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHD------ 349 A ELY K++ +G G+ VY + QF + GI H+ E F ++ +HD Sbjct: 36 AEELYKKLIDLGEEIGLATVYRVLNQFDDAGIVTRHHFEGGKSVFELSTQHHHDHLVCLD 95 Query: 350 ---LMEITEKMVSGMVKHITGSYKV 371 ++E ++ ++ K I Y V Sbjct: 96 CGEVIEFSDDVIEQRQKEIAAKYNV 120 >4MZD-A nrPDB Length = 488 Score = 32.3 bits (72), Expect = 0.65, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 21/42 (50%), Gaps = 1/42 (2%) Query: 299 APELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEF 340 AP ++ ++ VGGID I F N G D + P TT F Sbjct: 278 APSVFEDVIAVGGIDGYGNI-SDFSNIGADAIYAPAGTTANF 318 >5VXO-A nrPDB Length = 325 Score = 32.3 bits (72), Expect = 0.66, Method: Compositional matrix adjust. Identities = 39/165 (23%), Positives = 64/165 (38%), Gaps = 21/165 (12%) Query: 254 IRSFLDELGF----LEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPE--LYHKML 307 I+ F D+ F ++E PM N+IP A + + + L ++ P+ L+ + Sbjct: 121 IQWFADKFSFHLKGRKLEQPM-NLIPFVETAMGLLNFKAVCEETL--KVGPQVGLFLDAV 177 Query: 308 VVGGIDRVYEIGRQFRNEGIDLTHNPE--------FTTCEFYMAYADYHDLMEITEKMVS 359 V GG D IG E +D+ + + F + Y D+ D + + Sbjct: 178 VFGGEDFRASIGATSSKETLDILYARQKIVVIAKAFGLQAIDLVYIDFRDGAGLLRQSRE 237 Query: 360 GMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKAL 404 G TG K HP+ + F+P +I EEL A Sbjct: 238 GAAMGFTG--KQVIHPN--QIAVVQEQFSPSPEKIKWAEELIAAF 278 >6HA8-V nrPDB Length = 548 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 15/40 (37%), Positives = 22/40 (55%) Query: 160 SRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSII 199 S K + F H+N +++GDIIG+ G G K L +I Sbjct: 17 SYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKSTLLHLI 56 >3G17-A nrPDB Length = 294 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 15/48 (31%), Positives = 28/48 (58%), Gaps = 4/48 (8%) Query: 288 NELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEF 335 +++D+ L I +++K+LV GI+ + +GRQ + + HNPE Sbjct: 152 SQIDIVLEANIQQAIWYKLLVNLGINSITALGRQ----TVAIMHNPEI 195 >5ZG8-A nrPDB Length = 438 Score = 30.4 bits (67), Expect = 2.3, Method: Compositional matrix adjust. Identities = 10/35 (28%), Positives = 22/35 (62%) Query: 539 YGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAM 573 +G P +G+G+G++R ++ +++E + FP M Sbjct: 398 FGSVPHSGFGLGLERTVAWICGLAHVREAIPFPRM 432 >6MN8-A nrPDB Length = 505 Score = 30.0 bits (66), Expect = 3.3, Method: Compositional matrix adjust. Identities = 20/60 (33%), Positives = 32/60 (53%), Gaps = 6/60 (10%) Query: 194 GELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLIL--ND---FVRQKFIIRS 248 GE IP + L S C ML +H+ + ++ R+ + ++L ND F+ QKFI+ S Sbjct: 379 GEKRTIPID-GLASKCKDMLEEIHYSMYNRILEVRESHTKIVLEWNDFRSFLDQKFILLS 437 >6JP2-A nrPDB Length = 278 Score = 29.6 bits (65), Expect = 4.4, Method: Compositional matrix adjust. Identities = 26/88 (29%), Positives = 39/88 (44%), Gaps = 15/88 (17%) Query: 262 GFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYM---------RIAPELYHKMLVV--- 309 GF+E+ TP+ I A+A+ IT L ++ +AP LY M + Sbjct: 81 GFIEVRTPI--FISKDALARMTITEDKPLFKQVFWIDEKRALRPMLAPNLYSVMRDLRDH 138 Query: 310 -GGIDRVYEIGRQFRNEGIDLTHNPEFT 336 G +++E+G FR E H EFT Sbjct: 139 TDGPVKIFEMGSCFRKESHSGMHLEEFT 166 >4PI7-A nrPDB Length = 228 Score = 29.3 bits (64), Expect = 5.6, Method: Compositional matrix adjust. Identities = 12/38 (31%), Positives = 22/38 (57%) Query: 74 NQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQK 111 N+Y++ ++Q++ N E+P H++ DI D I K Sbjct: 169 NEYFENNQLNLYQMRWNPENPAQHQYASDIRWADKIAK 206 >3Q5R-A nrPDB Length = 284 Score = 28.5 bits (62), Expect = 7.9, Method: Compositional matrix adjust. Identities = 19/72 (26%), Positives = 36/72 (50%), Gaps = 5/72 (6%) Query: 397 VEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTC 456 +EE++KA +++ E F TE+ R+I + + A+E T L+ K + +E Sbjct: 66 LEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE-----QTISLVKKRMKRQMEYPA 120 Query: 457 INPTFICDHPQI 468 + F+ D +I Sbjct: 121 LGEVFVLDEEEI 132 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6CHD-A nrPDB 906 0.0 6ILH-A nrPDB 744 0.0 5HGQ-A nrPDB 668 0.0 5ELO-A nrPDB 624 e-179 4YCV-A nrPDB 611 e-175 4UP8-A nrPDB 587 e-168 1LYL-A nrPDB 566 e-162 1BBU-A nrPDB 556 e-159 4EX5-A nrPDB 544 e-155 3A74-A nrPDB 540 e-154 6NRZ-A nrPDB 496 e-140 6AQG-A nrPDB 493 e-140 6AQH-A nrPDB 488 e-138 3NEM-A nrPDB 373 e-103 4J15-A nrPDB 371 e-103 6OD8-A nrPDB 357 9e-99 1ASZ-A nrPDB 352 2e-97 1WYD-A nrPDB 343 1e-94 5XIX-A nrPDB 327 6e-90 1N9W-A nrPDB 321 8e-88 4WJ3-M nrPDB 318 4e-87 1IL2-A nrPDB 303 2e-82 3I7F-A nrPDB 296 2e-80 1X54-A nrPDB 287 8e-78 3A5Z-A nrPDB 280 1e-75 3G1Z-A nrPDB 279 3e-75 5W25-A nrPDB 258 5e-69 4RMF-A nrPDB 258 6e-69 1EFW-A nrPDB 221 6e-58 4AH6-A nrPDB 218 5e-57 3P8T-A nrPDB 205 4e-53 1NNH-A nrPDB 200 2e-51 Sequences not found previously or not previously below threshold: 2XGT-A nrPDB 248 6e-66 3M4P-A nrPDB 239 3e-63 5ZG8-A nrPDB 208 8e-54 3VQX-A nrPDB 64 2e-10 5GRO-A nrPDB 58 2e-08 6JP2-A nrPDB 54 2e-07 2ZNJ-A nrPDB 53 4e-07 11AS-A nrPDB 47 3e-05 4LNS-A nrPDB 46 6e-05 3L4G-A nrPDB 44 1e-04 3TUP-A nrPDB 42 6e-04 5LR8-A nrPDB 42 8e-04 3M8U-A nrPDB 38 0.014 1NJ8-A nrPDB 36 0.048 6HXI-A nrPDB 36 0.065 6HV9-B nrPDB 35 0.082 1ADJ-A nrPDB 34 0.17 2Q1Z-A nrPDB 34 0.27 2DU4-A nrPDB 33 0.43 2ALY-A nrPDB 32 0.76 4GX0-A nrPDB 31 1.1 4GVL-A nrPDB 31 1.1 2O1T-A nrPDB 31 1.5 1PYS-A nrPDB 31 1.6 2FD5-A nrPDB 31 1.8 4HKA-A nrPDB 31 1.9 5ICJ-A nrPDB 30 2.7 >6CHD-A nrPDB Length = 597 Score = 906 bits (2342), Expect = 0.0, Method: Composition-based stats. Identities = 597/597 (100%), Positives = 597/597 (100%) Query: 1 MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTT 60 MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTT Sbjct: 1 MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTT 60 Query: 61 DNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH 120 DNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH Sbjct: 61 DNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH 120 Query: 121 LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD 180 LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD Sbjct: 121 LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD 180 Query: 181 IIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFV 240 IIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFV Sbjct: 181 IIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFV 240 Query: 241 RQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAP 300 RQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAP Sbjct: 241 RQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAP 300 Query: 301 ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSG 360 ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSG Sbjct: 301 ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSG 360 Query: 361 MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR 420 MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR Sbjct: 361 MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR 420 Query: 421 KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE 480 KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE Sbjct: 421 KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE 480 Query: 481 GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG 540 GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG Sbjct: 481 GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG 540 Query: 541 LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV 597 LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV Sbjct: 541 LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV 597 >6ILH-A nrPDB Length = 521 Score = 744 bits (1921), Expect = 0.0, Method: Composition-based stats. Identities = 511/513 (99%), Positives = 512/513 (99%) Query: 70 SVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVA 129 SVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVA Sbjct: 2 SVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVA 61 Query: 130 GRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPG 189 GRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPG Sbjct: 62 GRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPG 121 Query: 190 KTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSK 249 KTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSK Sbjct: 122 KTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSK 181 Query: 250 IITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVV 309 IITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVV Sbjct: 182 IITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVV 241 Query: 310 GGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSY 369 GGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHD MEITEKMVSGMVKHITGSY Sbjct: 242 GGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDHMEITEKMVSGMVKHITGSY 301 Query: 370 KVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVA 429 KVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVA Sbjct: 302 KVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVA 361 Query: 430 KAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELF 489 KAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELF Sbjct: 362 KAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELF 421 Query: 490 VMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGM 549 VMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGM Sbjct: 422 VMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGM 481 Query: 550 GIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENV 582 GIDRVAMFLTDSNNIKEVLLFPAMKPEDKKEN+ Sbjct: 482 GIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENL 514 >5HGQ-A nrPDB Length = 524 Score = 668 bits (1723), Expect = 0.0, Method: Composition-based stats. Identities = 338/516 (65%), Positives = 418/516 (81%), Gaps = 1/516 (0%) Query: 68 EESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLK 127 + DP +Y+K+R+ I++ + G +PYPHKFHV ISL DFI KY+ L+ L DI Sbjct: 2 ADPSDPQEYFKLRTALINERRSKGINPYPHKFHVSISLADFIAKYNSLEKDVILNDIVQS 61 Query: 128 VAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGN 187 VAGR+ +KR SGGKLIFYDL GEG +LQV+AN+R + +E F +++++++RGDIIGV G Sbjct: 62 VAGRVFSKRESGGKLIFYDLHGEGTRLQVLANARFHSGDEAFDNLHDRIKRGDIIGVNGY 121 Query: 188 PGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIR 247 P ++K GELSIIPYEI L+PCLHMLPH HFGLK++ETRYR RYLDLI+N V+ +F+ R Sbjct: 122 PARSKSGELSIIPYEIIQLTPCLHMLPHTHFGLKNQETRYRMRYLDLIMNPDVKNRFVTR 181 Query: 248 SKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKML 307 S++I+++R +LD LGFLE+ETPMMN+I GGA AKPFIT+HN+LDM+LY+R+APELY KML Sbjct: 182 SRMISFLRRYLDNLGFLEVETPMMNLIAGGATAKPFITHHNDLDMDLYLRVAPELYLKML 241 Query: 308 VVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITG 367 VVGGIDRVYEIGR FRNEGID THNPEFT+CEFYMAYADY DLM+ITE M++ MV ++ G Sbjct: 242 VVGGIDRVYEIGRVFRNEGIDQTHNPEFTSCEFYMAYADYEDLMKITEDMLARMVYYMHG 301 Query: 368 SYKVTYHPDG-PEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDI 426 +YK+ YHP+G E Y+VDFTPPFR++N+ + L++ LG++ P + +T+E K D + Sbjct: 302 TYKIQYHPNGIVENPVYEVDFTPPFRKVNIYDGLQEKLGIQFPPADTLDTDEANKFFDKL 361 Query: 427 CVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERF 486 V VECP PRTTARLLDKL+GEFLE T I+PTF+ HPQIMSPLAKWHRS GLTERF Sbjct: 362 AVENNVECPAPRTTARLLDKLIGEFLEPTFISPTFLTGHPQIMSPLAKWHRSIPGLTERF 421 Query: 487 ELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAG 546 ELFV+ KEI NAYTELNDP+ QR F+EQAK K AGDDEA IDEN+CTALEYGLPPTAG Sbjct: 422 ELFVVTKEIVNAYTELNDPLTQRLRFDEQAKQKQAGDDEAQNIDENYCTALEYGLPPTAG 481 Query: 547 WGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENV 582 WGMGIDR+AM LTDSNNIKEVL FPAM+P++K NV Sbjct: 482 WGMGIDRLAMILTDSNNIKEVLFFPAMRPDEKGTNV 517 >5ELO-A nrPDB Length = 535 Score = 624 bits (1609), Expect = e-179, Method: Composition-based stats. Identities = 289/510 (56%), Positives = 377/510 (73%), Gaps = 4/510 (0%) Query: 67 EEESVDPNQYYK-IRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDIT 125 E ++ P +Y R + + +K G YPHKF + +SL + KY +++ G D T Sbjct: 13 EAQTQGPGSHYTDNRYKMMECIKDAGRPFYPHKFKISMSLPAYALKYGNVENGYIDKDTT 72 Query: 126 LKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYK-SEEEFIHINNKLRRGDIIGV 184 L ++GR+ + R+S KLIFYD+ E K+Q++AN + S EF ++++RRGD++G Sbjct: 73 LSLSGRVTSIRSSSSKLIFYDIFCEEQKVQIIANIMEHDISTGEFSVSHSEIRRGDVVGF 132 Query: 185 QGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKF 244 G PGK+K+GELS+ + LLSPC HMLP GLKD+E RYRQRYLDL+LN+ R+ F Sbjct: 133 TGFPGKSKRGELSLFSKSVVLLSPCYHMLPTAISGLKDQEVRYRQRYLDLMLNEESRKVF 192 Query: 245 IIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYH 304 +RS+ I YIR++ D LGFLE+ETPM+N+I GGA A+PFITYHNEL+ LYMRIAPELY Sbjct: 193 KLRSRAIKYIRNYFDRLGFLEVETPMLNMIYGGAAARPFITYHNELETQLYMRIAPELYL 252 Query: 305 KMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKH 364 K L+VGG+D+VYEIG+ FRNEGIDLTHNPEFT EFYMAYADY+DLM++TE+++SG+V Sbjct: 253 KQLIVGGLDKVYEIGKNFRNEGIDLTHNPEFTAMEFYMAYADYYDLMDLTEELISGLVLE 312 Query: 365 ITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILD 424 I GS K+ YHPDGPEG+ ++DFT P++R + VEE+E LG KL +++E + Sbjct: 313 IHGSLKIPYHPDGPEGKCIEIDFTTPWKRFSFVEEIESGLGEKLKRP--LDSQENIDFMV 370 Query: 425 DICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTE 484 ++C +E P PRT A+LLDKL G F+E C NP+FI DHPQ MSPLAKWHR K +TE Sbjct: 371 EMCEKHEIELPHPRTAAKLLDKLAGHFVETKCTNPSFIIDHPQTMSPLAKWHREKPEMTE 430 Query: 485 RFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPT 544 RFELFV+ KE+CNAYTELN+P++QR+ FE+QA AKA+GD EA IDE FC ALE+GLPPT Sbjct: 431 RFELFVLGKELCNAYTELNEPLQQRKFFEQQADAKASGDVEACPIDETFCLALEHGLPPT 490 Query: 545 AGWGMGIDRVAMFLTDSNNIKEVLLFPAMK 574 GWG+GIDR+ MFL D NNIKEV+LFPAM+ Sbjct: 491 GGWGLGIDRLIMFLADKNNIKEVILFPAMR 520 >4YCV-A nrPDB Length = 516 Score = 611 bits (1575), Expect = e-175, Method: Composition-based stats. Identities = 280/511 (54%), Positives = 371/511 (72%), Gaps = 5/511 (0%) Query: 71 VDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAG 130 VDP Y++ RS+ I K G +PYPHKF IS+ +FI+KY L G+HL D L + G Sbjct: 3 VDPRLYFENRSKFIQDQKDKGINPYPHKFERTISIPEFIEKYKDLGNGEHLEDTILNITG 62 Query: 131 RIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSE-EEFIHINNKLRRGDIIGVQGNPG 189 RI ASG KL F+DL G+G K+QV+AN + E F +K+RRGDI+G+ G PG Sbjct: 63 RIMRVSASGQKLRFFDLVGDGEKIQVLANYSFHNHEKGNFAECYDKIRRGDIVGIVGFPG 122 Query: 190 KTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSK 249 K+KKGELSI P E LLS CLHMLP +GLKD E RYRQRYLDL++N+ R F+ R+K Sbjct: 123 KSKKGELSIFPKETILLSACLHMLPMK-YGLKDTEIRYRQRYLDLLINESSRHTFVTRTK 181 Query: 250 IITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVV 309 II ++R+FL+E GF E+ETPMMN+I GGA A+PFIT+HN+LD++LY+RIA EL KML+V Sbjct: 182 IINFLRNFLNERGFFEVETPMMNLIAGGANARPFITHHNDLDLDLYLRIATELPLKMLIV 241 Query: 310 GGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSY 369 GGID+VYEIG+ FRNEGID THNPEFT+CEFY AYADY+DL++ +E S +V H+ G+Y Sbjct: 242 GGIDKVYEIGKVFRNEGIDNTHNPEFTSCEFYWAYADYNDLIKWSEDFFSQLVYHLFGTY 301 Query: 370 KVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVA 429 K++Y+ DGPE Q ++DFTPP+ ++++VEE+EK L + F++ ET + + +I Sbjct: 302 KISYNKDGPENQPIEIDFTPPYPKVSIVEEIEKVTNTILEQP--FDSNETIEKMINIIKE 359 Query: 430 KAVECPPPRTTARLLDKLVGEFLEVTCIN-PTFICDHPQIMSPLAKWHRSKEGLTERFEL 488 +E P P T A+LLD+L F+E + P FI +HPQIMSPLAK+HR+K GLTER E+ Sbjct: 360 HKIELPNPPTAAKLLDQLASHFIENKYNDKPFFIVEHPQIMSPLAKYHRTKPGLTERLEM 419 Query: 489 FVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWG 548 F+ KE+ NAYTELNDP +Q++ F+ Q K + GD EA +D FCT+LEYGLPPT G G Sbjct: 420 FICGKEVLNAYTELNDPFKQKECFKLQQKDREKGDTEAAQLDSAFCTSLEYGLPPTGGLG 479 Query: 549 MGIDRVAMFLTDSNNIKEVLLFPAMKPEDKK 579 +GIDR+ MFLT+ N+IK+V+LFP M+P + Sbjct: 480 LGIDRITMFLTNKNSIKDVILFPTMRPANGG 510 >4UP8-A nrPDB Length = 777 Score = 587 bits (1512), Expect = e-168, Method: Composition-based stats. Identities = 275/570 (48%), Positives = 373/570 (65%), Gaps = 63/570 (11%) Query: 74 NQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIH 133 Q + R + + + + G +P+PHKF+V I++ +FI KYS L+ ++D + VAGR+ Sbjct: 11 KQLFLNRCKDVEEYQKAGHNPWPHKFNVSITVPEFIAKYSGLEKS-QVSDDIVSVAGRVL 69 Query: 134 AKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKK 193 +KR+S L+F DL KLQ+M N Y+++E+F+ + + RGDI G G+P +TK Sbjct: 70 SKRSSSSALMFIDLHDSQTKLQIMLNKSAYENKEDFVSLTKMIYRGDICGFTGHPTRTKT 129 Query: 194 GELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITY 253 GELS+IP +LSPCLHMLP +H+GL D+ETR+R+RYLDLI+N + F++R+K++ Sbjct: 130 GELSLIPISGMILSPCLHMLPSMHYGLGDQETRFRKRYLDLIVNPESVKNFVLRTKVVKA 189 Query: 254 IRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGID 313 +R +LD+ GFLE+ETP++N IPGGA A+PFIT+HN+LD+ +YMRIAPELY K LVVGGI+ Sbjct: 190 VRKYLDDKGFLEVETPILNTIPGGATARPFITHHNQLDIQMYMRIAPELYLKELVVGGIN 249 Query: 314 RVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGS----- 368 RVYEIGR FRNEGID THNPEFTTCEFYMAYADY+D+M++TE+++ MVK ITG Sbjct: 250 RVYEIGRLFRNEGIDQTHNPEFTTCEFYMAYADYNDIMKMTEELLGNMVKDITGGSTKLE 309 Query: 369 ------------------------------------------YKVTYHPDGPEGQAYD-- 384 ++ Y+ DG +A Sbjct: 310 IKDRLMDINNEEDIKMLEKFFKEPIPRPFNSAECSKVIEKHCTELNYYYDGNNEKAMKKL 369 Query: 385 -----------VDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVE 433 +DFT PF+RI+ V LE+ G K+P + E L + Sbjct: 370 FADFVTEKKMVLDFTAPFKRISYVHALEEKFGEKIPRP--LDGPEALTFLKKQAIRFNAI 427 Query: 434 CPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKK 493 C P+TTAR++DKL G+ +EV + PTF+CD PQ+MSPLAK+HRS+ LTERFELF++K+ Sbjct: 428 CAEPQTTARVMDKLFGDLIEVDLVQPTFVCDQPQLMSPLAKYHRSEPELTERFELFILKR 487 Query: 494 EICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDR 553 EI NAYTELN+P+ QR FE+QAK KAAGDDEA +DE F A+E+ PPT GWG+GIDR Sbjct: 488 EIANAYTELNNPIVQRSNFEQQAKDKAAGDDEAQLVDEVFLDAIEHAFPPTGGWGLGIDR 547 Query: 554 VAMFLTDSNNIKEVLLFPAMKPEDKKENVA 583 +AM L D +NIKEV+LFP M+PED+ E A Sbjct: 548 LAMLLADVDNIKEVILFPTMRPEDELEKKA 577 >1LYL-A nrPDB Length = 504 Score = 566 bits (1459), Expect = e-162, Method: Composition-based stats. Identities = 223/510 (43%), Positives = 316/510 (61%), Gaps = 18/510 (3%) Query: 69 ESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLT--DITL 126 E++D N + R + + L+ G +P+ F D + +D + + + L +I + Sbjct: 10 EAIDFNDELRNRREKLAALRQQGV-AFPNDFRRDHT-SDQLHEEFDAKDNQELESLNIEV 67 Query: 127 KVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQG 186 VAGR+ +R G K F L+ G ++Q+ +R+ E + K GDIIG +G Sbjct: 68 SVAGRMMTRRIMG-KASFVTLQDVGGRIQLYV-ARDSLPEGVYNDQFKKWDLGDIIGARG 125 Query: 187 NPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFII 246 KT+ GELSI E+ LL+ L LP GL+D+E RYRQRYLDLI ND RQ F++ Sbjct: 126 TLFKTQTGELSIHCTELRLLTKALRPLPDKFHGLQDQEVRYRQRYLDLIANDKSRQTFVV 185 Query: 247 RSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKM 306 RSKI+ IR F+ GF+E+ETPMM +IPGGA A+PFIT+HN LD+++Y+RIAPELY K Sbjct: 186 RSKILAAIRQFMVARGFMEVETPMMQVIPGGASARPFITHHNALDLDMYLRIAPELYLKR 245 Query: 307 LVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHIT 366 LVVGG +RV+EI R FRNEGI + HNPEFT E YMAYADYHDL+E+TE + + + + Sbjct: 246 LVVGGFERVFEINRNFRNEGISVRHNPEFTMMELYMAYADYHDLIELTESLFRTLAQEVL 305 Query: 367 GSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDI 426 G+ KVTY + DF PF ++ M E ++K PET++ + + + Sbjct: 306 GTTKVTYG-------EHVFDFGKPFEKLTMREAIKKY----RPETDMADLD-NFDAAKAL 353 Query: 427 CVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERF 486 + + R++ ++ E E I PTFI ++P +SPLA+ + +T+RF Sbjct: 354 AESIGITVEKSWGLGRIVTEIFDEVAEAHLIQPTFITEYPAEVSPLARRNDVNPEITDRF 413 Query: 487 ELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAG 546 E F+ +EI N ++ELND Q + F+EQ AKAAGDDEAMF DE++ TALEYGLPPTAG Sbjct: 414 EFFIGGREIGNGFSELNDAEDQAERFQEQVNAKAAGDDEAMFYDEDYVTALEYGLPPTAG 473 Query: 547 WGMGIDRVAMFLTDSNNIKEVLLFPAMKPE 576 G+GIDR+ M T+S+ I++V+LFPAM+P+ Sbjct: 474 LGIGIDRMIMLFTNSHTIRDVILFPAMRPQ 503 >1BBU-A nrPDB Length = 504 Score = 556 bits (1433), Expect = e-159, Method: Composition-based stats. Identities = 219/507 (43%), Positives = 306/507 (60%), Gaps = 18/507 (3%) Query: 71 VDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLT--DITLKV 128 VD N K R + + L+ G +P+ F D + +D + + + L +I + V Sbjct: 12 VDLNNELKTRREKLANLREQGI-AFPNDFRRDHT-SDQLHAEFDGKENEELEALNIEVAV 69 Query: 129 AGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNP 188 AGR+ +R G K F L+ G ++Q+ + E + K GDI+G +G Sbjct: 70 AGRMMTRRIMG-KASFVTLQDVGGRIQLYVARDDLP-EGVYNEQFKKWDLGDILGAKGKL 127 Query: 189 GKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRS 248 KTK GELSI E+ LL+ L LP GL+D+E RYRQRYLDLI ND R F +RS Sbjct: 128 FKTKTGELSIHCTELRLLTKALRPLPDKFHGLQDQEARYRQRYLDLISNDESRNTFKVRS 187 Query: 249 KIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLV 308 +I++ IR F+ GF+E+ETPMM +IPGGA A+PFIT+HN LD+++Y+RIAPELY K LV Sbjct: 188 QILSGIRQFMVNRGFMEVETPMMQVIPGGAAARPFITHHNALDLDMYLRIAPELYLKRLV 247 Query: 309 VGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGS 368 VGG +RV+EI R FRNEGI + HNPEFT E YMAYADY DL+E+TE + + + I G Sbjct: 248 VGGFERVFEINRNFRNEGISVRHNPEFTMMELYMAYADYKDLIELTESLFRTLAQDILGK 307 Query: 369 YKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICV 428 +VTY +DF PF ++ M E ++K PET++ + + I Sbjct: 308 TEVTYGD-------VTLDFGKPFEKLTMREAIKKY----RPETDMADLD-NFDSAKAIAE 355 Query: 429 AKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFEL 488 + + R++ ++ E E I PTFI ++P +SPLA+ + +T+RFE Sbjct: 356 SIGIHVEKSWGLGRIVTEIFEEVAEAHLIQPTFITEYPAEVSPLARRNDVNPEITDRFEF 415 Query: 489 FVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWG 548 F+ +EI N ++ELND Q Q F +Q AK AGDDEAMF DE++ TALE+GLPPTAG G Sbjct: 416 FIGGREIGNGFSELNDAEDQAQRFLDQVAAKDAGDDEAMFYDEDYVTALEHGLPPTAGLG 475 Query: 549 MGIDRVAMFLTDSNNIKEVLLFPAMKP 575 +GIDR+ M T+S+ I++V+LFPAM+P Sbjct: 476 IGIDRMVMLFTNSHTIRDVILFPAMRP 502 >4EX5-A nrPDB Length = 529 Score = 544 bits (1401), Expect = e-155, Method: Composition-based stats. Identities = 201/516 (38%), Positives = 283/516 (54%), Gaps = 14/516 (2%) Query: 64 VGPEEE-SVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHL-QPGDHL 121 + P+ + D NQ R + L+ G YP+ F D Y+ + Sbjct: 26 IQPQAAVAADENQIVAERRDKLRALRDQGI-AYPNDFQPTHHAADLQTAYADADKEALEA 84 Query: 122 TDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDI 181 + + +AGR+ KR G K F ++ ++Q + +E K GDI Sbjct: 85 KSLEVAIAGRMMLKRVMG-KASFATVQDGSGQIQFFVTPADVGAET--YDAFKKWDLGDI 141 Query: 182 IGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVR 241 + +G +T KGELS+ ++ LL+ L LP GL D+ETRYRQRY+DLI+ R Sbjct: 142 VAARGVLFRTNKGELSVKCTQLRLLAKALRPLPDKFHGLADQETRYRQRYVDLIVTPETR 201 Query: 242 QKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPE 301 F R+K I IR F+ + F+E+ETPM++ IPGGA AKPF+T+HN LDM +++RIAPE Sbjct: 202 TTFRARTKAIASIRKFMGDADFMEVETPMLHPIPGGAAAKPFVTHHNALDMEMFLRIAPE 261 Query: 302 LYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGM 361 LY K L+VGG +RV+EI R FRNEG+ HNPEFT EFY AY DY LM+ TE+++ Sbjct: 262 LYLKRLIVGGFERVFEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDFTERLIRQA 321 Query: 362 VKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRK 421 G+ + Y Q ++D PF R+ + + ++K + L + R Sbjct: 322 AVDALGTATIQY-------QGRELDLAQPFHRLTITQAIQKY-APSYTDGQLSDDAFLRS 373 Query: 422 ILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEG 481 L + V L L E E PTFI D+P +SPLA+ + G Sbjct: 374 ELKRLGVDVTQPAFLNAGIGALQLALFEETAEAQLWEPTFIIDYPIEVSPLARESDTVAG 433 Query: 482 LTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGL 541 +TERFELF+ +EI N ++ELNDP Q F++Q + K AGD+EAMF D ++ ALEYG+ Sbjct: 434 ITERFELFITGREIANGFSELNDPEDQAARFKKQVEQKDAGDEEAMFFDADYIRALEYGM 493 Query: 542 PPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPED 577 PPT G G+GIDR+ M LTDS I++VLLFP ++ ED Sbjct: 494 PPTGGCGIGIDRLVMLLTDSPTIRDVLLFPHLRRED 529 >3A74-A nrPDB Length = 493 Score = 540 bits (1392), Expect = e-154, Method: Composition-based stats. Identities = 211/502 (42%), Positives = 303/502 (60%), Gaps = 17/502 (3%) Query: 74 NQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGD-HLTDITLKVAGRI 132 N ++R + + +++ G DP+ +F + + Y L + I + VAGRI Sbjct: 6 NDQLRVRREKLKKIEELGVDPFGKRFERTHKAEELFELYGDLSKEELEEQQIEVAVAGRI 65 Query: 133 HAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTK 192 KR G K F ++ ++Q+ + ++ + GDI+GV+G KTK Sbjct: 66 MTKRGMG-KAGFAHIQDVTGQIQIYVRQDDVGEQQ--YELFKISDLGDIVGVRGTMFKTK 122 Query: 193 KGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIIT 252 GELSI L+ L LP + GLKD E RYRQRYLDLI+N ++ FI RS II Sbjct: 123 VGELSIKVSSYEFLTKALRPLPEKYHGLKDIEQRYRQRYLDLIMNPESKKTFITRSLIIQ 182 Query: 253 YIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGI 312 +R +LD G+LE+ETPMM+ + GGA A+PFIT+HN LDM LYMRIA EL+ K L+VGG+ Sbjct: 183 SMRRYLDSHGYLEVETPMMHAVAGGAAARPFITHHNALDMTLYMRIAIELHLKRLIVGGL 242 Query: 313 DRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVT 372 ++VYEIGR FRNEGI HNPEFT E Y AYAD+ D+M++TE +++ + + G+ K+ Sbjct: 243 EKVYEIGRVFRNEGISTRHNPEFTMLELYEAYADFRDIMKLTENLIAHIATEVLGTTKIQ 302 Query: 373 YHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAV 432 Y + VD TP +RR++MV+ +++ +G+ EE R ++ V Sbjct: 303 YG-------EHLVDLTPEWRRLHMVDAIKEYVGVDF--WRQMSDEEAR----ELAKEHGV 349 Query: 433 ECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMK 492 E P T ++++ + +E I PTFI HP +SPLAK + T+RFELF++ Sbjct: 350 EVAPHMTFGHIVNEFFEQKVEDKLIQPTFIYGHPVEISPLAKKNPDDPRFTDRFELFIVG 409 Query: 493 KEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGID 552 +E NA+TELNDP+ QRQ FEEQ K + G+DEA +DE+F ALEYG+PPT G G+G+D Sbjct: 410 REHANAFTELNDPIDQRQRFEEQLKEREQGNDEAHEMDEDFLEALEYGMPPTGGLGIGVD 469 Query: 553 RVAMFLTDSNNIKEVLLFPAMK 574 R+ M LT+S +I++VLLFP M+ Sbjct: 470 RLVMLLTNSPSIRDVLLFPQMR 491 >6NRZ-A nrPDB Length = 534 Score = 496 bits (1276), Expect = e-140, Method: Composition-based stats. Identities = 197/523 (37%), Positives = 288/523 (55%), Gaps = 23/523 (4%) Query: 75 QYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDI-----TLKVA 129 + Y R+ + +++ G +PYP+++ + + + ++ + GD ++ A Sbjct: 19 EDYLYRTSKLKEIRDLGINPYPYQYTDCLEVQEIRNQFVDNELGDSEAAFRKETPKVRFA 78 Query: 130 GRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIH--------INNKLRRGDI 181 GR+ R+ G K F + K+QVM N I KL GDI Sbjct: 79 GRLVLFRSMG-KNAFGQILDNDAKIQVMFNRDFSAVAGLAADAGISPIKFIEKKLDLGDI 137 Query: 182 IGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVR 241 +G++G T GEL+++ +TLL L LP H GL DKE RYR+R+ DLI ++ VR Sbjct: 138 LGLEGYLFFTHSGELTVLVETVTLLCKSLISLPDKHAGLADKEIRYRKRWADLISSEDVR 197 Query: 242 QKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPE 301 + F+ RS+I+ IR ++D+ FLE+ETP++ + GGA A PF+T L +++RI+ E Sbjct: 198 KTFLTRSRILKLIREYMDQQSFLEVETPILQTVYGGAEATPFVTTLQALHAEMFLRISLE 257 Query: 302 LYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGM 361 + K L+VGG+ RVYEIG+ FRNEGID THNPEFT E Y AY DY+D+M+ E +V + Sbjct: 258 IALKKLLVGGMSRVYEIGKVFRNEGIDRTHNPEFTMIEAYAAYWDYNDVMKCVENLVEYI 317 Query: 362 VKHI-TGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR 420 V+ + G +V Y Q VDF P+ R+ M E + G+ + E + Sbjct: 318 VRALNNGETQVQYSHLKSGPQV--VDFKAPWIRMTMKESISVYGGVDVDLHADHELRKIL 375 Query: 421 KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRS-K 479 + + V A L D+LV + I P I DHP +PL K RS Sbjct: 376 ETQTSLPEKTYVHASRGELIALLFDELVCD----KLIAPHHITDHPLETTPLCKTLRSGD 431 Query: 480 EGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDD-EAMFIDENFCTALE 538 E L ERFE F + KE+CNAY+ELNDP++QR+L EEQ + KA D E IDE F AL Sbjct: 432 ETLVERFESFCLGKELCNAYSELNDPLQQRKLLEEQMRKKALNPDSEYHPIDEEFLEALC 491 Query: 539 YGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKEN 581 G+PP G+G+GIDR+ M LTD+ +I++VL FP M+ + K++ Sbjct: 492 QGMPPAGGFGIGIDRLVMMLTDAASIRDVLFFPVMRRIEAKKD 534 >6AQG-A nrPDB Length = 506 Score = 493 bits (1269), Expect = e-140, Method: Composition-based stats. Identities = 194/510 (38%), Positives = 285/510 (55%), Gaps = 20/510 (3%) Query: 68 EESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLK 127 ES P Q ++IR +L G DPYP +L + Y+ L P D T+ + Sbjct: 12 AESNIPEQ-FRIRRDKRARLLAEGYDPYPVAIERTHTLAEIRATYADL-PTDSATEDIVG 69 Query: 128 VAGRIHAKRASGGKLIFYDLRG-EGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQG 186 VAGR+ R +G KL F L+ +G +LQ M S + E + GD++ V G Sbjct: 70 VAGRVVFARNTG-KLCFATLQDGDGTQLQAMI-SLDEVGRESLDRWKADVDIGDVVYVHG 127 Query: 187 NPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFII 246 +++GELS++ + + L LP H + +E+R RQRY+DLI+ R+ Sbjct: 128 TVISSRRGELSVLADSWRMAAKALRPLPVAHKEMS-EESRVRQRYVDLIVRPQAREVARQ 186 Query: 247 RSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKM 306 R +I +R+ L+ GFLE+ETPM+ + GGA A+PF+T+ N LD++LY+RIAPEL+ K Sbjct: 187 RIAVIRAVRNALERRGFLEVETPMLQTLAGGAAARPFVTHSNALDIDLYLRIAPELFLKR 246 Query: 307 LVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHIT 366 +VGG DRV+E+ R FRNEG D TH+PEF+ E Y Y Y D IT +++ + Sbjct: 247 CIVGGFDRVFELNRVFRNEGSDSTHSPEFSMLETYQTYGTYDDSALITRELIQEVADEAI 306 Query: 367 GSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDI 426 G+ +++ P+G YD+D + + M L +ALG ++ L DI Sbjct: 307 GTRQLSM----PDGSVYDIDGE--WATMEMYSSLSEALGEQITPETTVAR------LRDI 354 Query: 427 CVAKAVECPPPR-TTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTER 485 VE +L+++L + PTF+ D P +PL + HRS G+TE+ Sbjct: 355 ASGLDVEIDNSVFGHGKLVEELWEHAVGNKLTAPTFVKDFPVETTPLTRQHRSIPGVTEK 414 Query: 486 FELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTA 545 ++L+V E+ Y+ELNDP+ QR F +QA+A AAGDDEAM +DE+F TALEYG+PP Sbjct: 415 WDLYVRGVELATGYSELNDPVVQRDRFADQARAAAAGDDEAMQLDEDFLTALEYGMPPCT 474 Query: 546 GWGMGIDRVAMFLTDSNNIKEVLLFPAMKP 575 G GMGIDR+ M LT +I+E +LFP ++P Sbjct: 475 GTGMGIDRLLMCLTGL-SIRETVLFPIVRP 503 >6AQH-A nrPDB Length = 508 Score = 488 bits (1256), Expect = e-138, Method: Composition-based stats. Identities = 204/514 (39%), Positives = 285/514 (55%), Gaps = 26/514 (5%) Query: 69 ESVDPN--QYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITL 126 ESVDP+ + ++IR L G PYP +L + Q Y L P D T + Sbjct: 13 ESVDPDLPEQFRIRQAKRADLLAQGRQPYPVDVPRTHTLLEIRQAYPDL-PVDARTGEIV 71 Query: 127 KVAGRIHAKRASGGKLIFYDLR-GEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQ 185 V GR+ R SG KL F L+ G+G +LQ M S +E + + GDI+ V Sbjct: 72 GVTGRVVFARNSG-KLCFATLQEGDGTQLQAMI-SLAEVGQEALDNWKTYVDIGDIVFVH 129 Query: 186 GNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFI 245 G +K+GELS++ + + L LP H + +E+R RQRY+DLI+ D R+ Sbjct: 130 GEVITSKRGELSVLADSWQMAAKALRPLPVAHKEMS-EESRVRQRYVDLIVRDQARKVAR 188 Query: 246 IRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHK 305 R ++ IRS L+ GFLE+ETPM+ + GGA A+PF+T+ N LD LY+RIAPEL+ K Sbjct: 189 QRIAVMRAIRSALERRGFLEVETPMLQTLAGGAAARPFVTHSNALDTELYLRIAPELFLK 248 Query: 306 MLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHI 365 +VGG +RV+E+ R FRNEG D TH+PEF E Y AY Y D +T +++ + Sbjct: 249 RCLVGGFERVFELNRVFRNEGADSTHSPEFVMLETYQAYGTYDDSAVVTRELIQEVADEA 308 Query: 366 TGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDD 425 G+ +V P+G YD+D + I M L +ALG ++ ET Sbjct: 309 IGTRQVPL----PDGTVYDLDGE--WESIQMYPSLSEALGEEITPDTPAETL-------- 354 Query: 426 ICVAKAVECPPPRTTARLLDKLVGEFLEV----TCINPTFICDHPQIMSPLAKWHRSKEG 481 +A + PR KLV E E PTF+ D P +PL + HRS G Sbjct: 355 WAIADRLGLDIPRDRGYGHGKLVEELWEHTVGAKLWAPTFVKDFPVETTPLTRSHRSIPG 414 Query: 482 LTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGL 541 +TE+++L+V + E+ Y+EL DP+ QR+ FE QA+A AAGDDEAM +DE+F ALEYG+ Sbjct: 415 VTEKWDLYVRRIELATGYSELTDPIIQRERFEAQARAAAAGDDEAMALDEDFLAALEYGM 474 Query: 542 PPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKP 575 PP+ G GMGIDR+ M LT +I+E +LFP +KP Sbjct: 475 PPSTGTGMGIDRLMMTLTGL-SIRETVLFPIVKP 507 >3NEM-A nrPDB Length = 438 Score = 373 bits (956), Expect = e-103, Method: Composition-based stats. Identities = 117/478 (24%), Positives = 203/478 (42%), Gaps = 55/478 (11%) Query: 108 FIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEE 167 + YS + + L +KVAG + + GG + F +R +Q+ A + + Sbjct: 2 YRTHYSS-EITEELNGQKVKVAGWVWEVKDLGG-IKFLWIRDRDGIVQITAPKKKV--DP 57 Query: 168 EFIHINNKLRRGDIIGVQGNPGKTKKGEL--SIIPYEITLLSPCLHMLPHLHFGL--KDK 223 E + KLR D++ V+G T K +L I+P +I +L+ LP G + Sbjct: 58 ELFKLIPKLRSEDVVAVEGVVNFTPKAKLGFEILPEKIVVLNRAETPLPLDPTGKVKAEL 117 Query: 224 ETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETP--MMNIIPGGAVAK 281 +TR R++DL + V F IRS + +R F E GF+EI TP + GG Sbjct: 118 DTRLDNRFMDLRRPE-VMAIFKIRSSVFKAVRDFFHENGFIEIHTPKIIATATEGGTELF 176 Query: 282 PFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGID-LTHNPEFTTCEF 340 P + + ++ +P+LY ++++ G+DRVYEI FR E + H E + + Sbjct: 177 P----MKYFEEDAFLAQSPQLYKQIMMASGLDRVYEIAPIFRAEEHNTTRHLNEAWSIDS 232 Query: 341 YMAY-ADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEE 399 MA+ D ++M E++V+ + ++ E + + PF R++ + Sbjct: 233 EMAFIEDEEEVMSFLERLVAHAINYVREHNAKELDILNFELEEPKL----PFPRVSYDKA 288 Query: 400 LEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINP 459 LE IL D+ E P ++L+G+++ P Sbjct: 289 LE--------------------ILGDL----GKEIPWGEDIDTEGERLLGKYMMENENAP 324 Query: 460 -TFICDHPQIMSPLAKW-HRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAK 517 F+ +P P + +K + F+L EI + + + + EQ K Sbjct: 325 LYFLYQYPSEAKPFYIMKYDNKPEICRAFDLEYRGVEISSGGQREH----RHDILVEQIK 380 Query: 518 AKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKP 575 K + F + A YG+PP G+G+G +R+ + D NI+EV+LFP + Sbjct: 381 EKGLNPESFEF----YLKAFRYGMPPHGGFGLGAERLIKQMLDLPNIREVILFPRDRR 434 >4J15-A nrPDB Length = 521 Score = 371 bits (952), Expect = e-103, Method: Composition-based stats. Identities = 98/475 (20%), Positives = 185/475 (38%), Gaps = 62/475 (13%) Query: 122 TDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDI 181 D + V R+H RA G K F LR + +Q + ++ S++ + + + I Sbjct: 76 ADEVVWVRARVHTSRAKG-KQCFLVLRQQQFNVQALVAVGDHASKQ-MVKFAANINKESI 133 Query: 182 IGVQGNPGKTKKGELSIIPYEITLLSPCLHML----PHLHFGLKD--------------- 222 + V+G K + S ++ L ++++ P L L D Sbjct: 134 VDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRAT 193 Query: 223 --KETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVA 280 ++TR R +DL + + F ++S I R L GF+EI+TP + I + Sbjct: 194 VNQDTRLDNRVIDLRTST-SQAVFRLQSGICHLFRETLINKGFVEIQTPKI--ISAASEG 250 Query: 281 KPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDL-THNPEFTTCE 339 + + N Y+ +P+LY +M + ++V+ IG FR E + H EF + Sbjct: 251 GANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLD 310 Query: 340 FYMAY-ADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVE 398 MA+ YH++ME + + K + ++ + F P R+ E Sbjct: 311 IEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCE 370 Query: 399 ELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCIN 458 L + VE + +KL+G ++ Sbjct: 371 ALA------------------------MLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDT 406 Query: 459 PTFICD-HPQIMSPLAKWHRS-KEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQA 516 +I D +P + P + +++F+ +EI + ++DP QL E+A Sbjct: 407 DFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDP----QLLTERA 462 Query: 517 KAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 ++ + + + +G PP AG G+G++RV M +N+++ +FP Sbjct: 463 LHHGIDLEK----IKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 513 >6OD8-A nrPDB Length = 558 Score = 357 bits (915), Expect = 9e-99, Method: Composition-based stats. Identities = 105/492 (21%), Positives = 195/492 (39%), Gaps = 64/492 (13%) Query: 120 HLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRG 179 L D T+ + R+ R G K+ F LR +Q MA +E I ++ Sbjct: 83 ELVDKTVLIRARVSTTRKKG-KMAFMVLRDGSDSVQAMAAVEG-DVPKEMIDFMGQIATE 140 Query: 180 DIIGVQGNPGKTKKGELSIIPYEITLLSPCLHM----LPHLHFGLKDK------------ 223 I+ V+ K ++ S +I L +H L L F L+D Sbjct: 141 SIVDVEATVCKVEQPITSTSHSDIELKVKKIHTVTESLRTLPFTLEDASRKESAEGAKVN 200 Query: 224 -ETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKP 282 +TR R++DL F ++S++ Y R FL + F EI +P + P A Sbjct: 201 LDTRLNSRWMDLRT-LASGAIFRLQSRVCQYFRQFLIDKDFCEIHSPKIINAPSEGGA-- 257 Query: 283 FITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDL-THNPEFTTCEFY 341 + + Y+ +P+LY +M++ G + RV+E+G FR+E + H EF + Sbjct: 258 NVFKLEYFNRFAYLAQSPQLYKQMVLQGDVPRVFEVGPVFRSENSNTHRHLTEFVGLDVE 317 Query: 342 MAYAD-YHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEEL 400 M + Y++++++ E + + + + ++ H + F P ++ E Sbjct: 318 MRIDEHYYEVLDVAESLFNYIFE------RLATHTKELKNVCQQYPFEPLVWKLT--PER 369 Query: 401 EKALGMKLPETNLFETEETR-------------------KILDDICVAKAVECPPPRTTA 441 K LG+ + + T++ + ++L+ + K TT Sbjct: 370 IKELGVGVISEGVVPTDKFQARVHNMDSRMLRINYMHCIELLNTVLDEKMAPTDDINTTN 429 Query: 442 RLLDKLVGEFLEVTCINPTFICD-HPQIMSPLAKW-HRSKEGLTERFELFVMKKEICNAY 499 +KL+G+ ++ FI D P P + T +++F+ +EI + Sbjct: 430 ---EKLLGKLVKERYGTDFFISDRFPSSARPFYTMECKDDVRFTNSYDMFIRGEEISSGA 486 Query: 500 TELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLT 559 ++DP A+AK D + + + G P G+G+G++RV M Sbjct: 487 QRIHDPDL------LLARAKMLNVDLTPI--KEYVDSFRLGAWPHGGFGIGLERVVMLYL 538 Query: 560 DSNNIKEVLLFP 571 +N++ LFP Sbjct: 539 GLSNVRLASLFP 550 >1ASZ-A nrPDB Length = 490 Score = 352 bits (904), Expect = 2e-97, Method: Composition-based stats. Identities = 110/490 (22%), Positives = 187/490 (38%), Gaps = 60/490 (12%) Query: 109 IQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQ--VMANSRNYKSE 166 K+ L +D + R+H R G L F LR + +Q V AN S+ Sbjct: 26 RVKFVDLDEA-KDSDKEVLFRARVHNTRQQGATLAFLTLRQQASLIQGLVKANKEGTISK 84 Query: 167 EEFIHINNKLRRGDIIGVQGNPGKTKKGE-------LSIIPYEITLLSPCLHMLPHLHF- 218 + L I+ V+G K + L I +I +S LP L Sbjct: 85 N-MVKWAGSLNLESIVLVRGIVKKVDEPIKSATVQNLEIHITKIYTISETPEALPILLED 143 Query: 219 -------------GLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLE 265 + + +TR R +DL + F I++ + R +L F E Sbjct: 144 ASRSEAEAEAAGLPVVNLDTRLDYRVIDLRTVTN-QAIFRIQAGVCELFREYLATKKFTE 202 Query: 266 IETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNE 325 + TP + P + + Y+ +P+ + L+V +RVYEIG FR E Sbjct: 203 VHTPKLLGAPSEGGSS--VFEVTYFKGKAYLAQSPQFNKQQLIVADFERVYEIGPVFRAE 260 Query: 326 GIDL-THNPEFTTCEFYMAYAD-YHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAY 383 + H EFT + MA+ + YH++++ ++ + + P+ A+ Sbjct: 261 NSNTHRHMTEFTGLDMEMAFEEHYHEVLDTLSELFVFIFSEL------------PKRFAH 308 Query: 384 DVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARL 443 +++ R+ VEE KLP+ T K ++ A E + Sbjct: 309 EIEL---VRKQYPVEEF------KLPKDGKM-VRLTYKEGIEMLRAAGKEIGDFEDLSTE 358 Query: 444 LDKLVGEFLEVTCINPTFICD-HPQIMSPLAKWHRS-KEGLTERFELFVMKKEICNAYTE 501 +K +G+ + +I D P + P + ++ F+ +EI + Sbjct: 359 NEKFLGKLVRDKYDTDFYILDKFPLEIRPFYTMPDPANPKYSNSYDFFMRGEEILSGAQR 418 Query: 502 LNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDS 561 ++D L +E+ KA ++ D +C YG PP AG G+G++RV MF D Sbjct: 419 IHD----HALLQERMKAHGLSPEDPGLKD--YCDGFSYGCPPHAGGGIGLERVVMFYLDL 472 Query: 562 NNIKEVLLFP 571 NI+ LFP Sbjct: 473 KNIRRASLFP 482 >1WYD-A nrPDB Length = 429 Score = 343 bits (880), Expect = 1e-94, Method: Composition-based stats. Identities = 124/482 (25%), Positives = 199/482 (41%), Gaps = 68/482 (14%) Query: 101 VDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANS 160 + D +Y + AG +H R GGK F LR + QV+ + Sbjct: 3 RSHFIADVTPEY---------DGKEVIWAGWVHLLRDLGGK-KFIILRDKTGLGQVVVDK 52 Query: 161 RNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKGE--LSIIPYEITLLSPCLHMLPHLHF 218 I+ +L + +I V+G K+ + + EITLLS LP Sbjct: 53 -----NSSAFGISQELTQESVIQVRGIVKADKRAPRGIELHAEEITLLSKAKAPLPLDVS 107 Query: 219 GL--KDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETP--MMNII 274 G D +TR R+R LDL + ++ I+S + R L + GF+EI TP + + Sbjct: 108 GKVKADIDTRLRERVLDLRRQE-MQAVIKIQSLALKAFRETLYKEGFIEIFTPKIIASAT 166 Query: 275 PGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLT-HNP 333 GGA P I ++ +P+LY + L+ G ++RV+E+ +R E D H Sbjct: 167 EGGAQLFPVI----YFGKEAFLAQSPQLYKE-LMAGVVERVFEVAPAWRAEESDTPFHLA 221 Query: 334 EFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRR 393 EF + + MA+ADY+D+M++ EK++ +VK I K E + P +R Sbjct: 222 EFISMDVEMAFADYNDVMQLLEKILHNIVKTIKEEGKEELKILNYEPPEVKI----PIKR 277 Query: 394 INMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLE 453 + E +E I +K +++ E L+ Sbjct: 278 LKYTEAIE------------------------ILRSKGYNIKFGDDIGTPELRILNEELK 313 Query: 454 VTCINPTFICDHPQIMSPLAKWHR-SKEGLTERFELFVMKKEICNAYTELNDPMRQRQLF 512 FI D P P + L+E F+L EI + T + +R++ Sbjct: 314 EDL---YFIVDWPSDARPFYTKSKSENPELSESFDLIYKFLEIVSGSTRNH----KREVL 366 Query: 513 EEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPA 572 EE K K + F F +YG+PP AG+GMG+ R+ + LT ++KE++ FP Sbjct: 367 EEALKKKGLKPESFEF----FLKWFDYGMPPHAGFGMGLARLMVMLTGIQSVKEIVPFPR 422 Query: 573 MK 574 K Sbjct: 423 DK 424 >5XIX-A nrPDB Length = 472 Score = 327 bits (839), Expect = 6e-90, Method: Composition-based stats. Identities = 97/468 (20%), Positives = 170/468 (36%), Gaps = 71/468 (15%) Query: 123 DITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNK--LRRGD 180 +KV G +H R G L+F LR LQ + E N L Sbjct: 49 GQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLAD-------ELCQCYNGVLLSTES 101 Query: 181 IIGVQGNPGKTKKG-------ELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLD 233 + V G T KG ELS +E+ L+P +L D + + R++ Sbjct: 102 SVAVYGMLNLTPKGKQAPGGHELSCDFWELIGLAPA-GGADNLINEESDVDVQLNNRHM- 159 Query: 234 LILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMM--NIIPGGAVAKPFITYHNELD 291 +I + + + RS + R + G+ E+ P + + GGA + + Sbjct: 160 MIRGENMSKILKARSMVTRCFRDHFFDRGYYEVTPPTLVQTQVEGGAT----LFKLDYFG 215 Query: 292 MNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNE-GIDLTHNPEFTTCEFYMAYADYHDL 350 ++ + +LY + + + V+ I + +R E H E+T E + + DL Sbjct: 216 EEAFLTQSSQLYLETCL-PALGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFLTFDDL 274 Query: 351 MEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPP---FRRINMVEELE--KALG 405 + E +V +V I S P G + +F PP F+R+N + + K Sbjct: 275 LNRLEDLVCDVVDRILKS------PAGSIVHELNPNFQPPKRPFKRMNYSDAIVWLKEHD 328 Query: 406 MKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDH 465 +K + +E E P RL+ + E P +C Sbjct: 329 VKKEDGTFYEFGE----------------DIPEAPERLMTDTINE--------PILLCRF 364 Query: 466 PQIMSPLA-KWHRSKEGLTERFELFVMKK-EICNAYTELNDPMRQRQLFEEQAKAKAAGD 523 P + + LTE ++ + EI + D E A K G Sbjct: 365 PVEIKSFYMQRCPEDSRLTESVDVLMPNVGEIVGGSMRIFDSE------EILAGYKREGI 418 Query: 524 DEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 D + + +YG P G+G+G++R ++ + +I++V L+P Sbjct: 419 DPTPYY--WYTDQRKYGTCPHGGYGLGLERFLTWILNRYHIRDVCLYP 464 >1N9W-A nrPDB Length = 422 Score = 321 bits (821), Expect = 8e-88, Method: Composition-based stats. Identities = 98/466 (21%), Positives = 183/466 (39%), Gaps = 59/466 (12%) Query: 115 LQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINN 174 ++ +++ G +H +R G ++ F LR +QV+ E + + Sbjct: 5 VRDLKAHVGQEVELLGFLHWRRDLG-RIQFLLLRDRSGVVQVVTGGLKLPLPESALRV-- 61 Query: 175 KLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLP---HLHFGLKDKETRYRQRY 231 RG ++ P G L + E+ +LSP L P + +T RY Sbjct: 62 ---RGLVVENAKAP-----GGLEVQAKEVEVLSPALEPTPVEIPKEEWRANPDTLLEYRY 113 Query: 232 LDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELD 291 + L + R +++ ++ R +LD F EI TP ++ GA + + + Sbjct: 114 VTL-RGEKARAPLKVQAALVRGFRRYLDRQDFTEIFTP--KVVRAGAEGGSGLFGVDYFE 170 Query: 292 MNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDL-THNPEFTTCEFYMAY-ADYHD 349 Y+ +P+LY + ++VG +RVYE+ +R E H E+ + + M + AD D Sbjct: 171 KRAYLAQSPQLYKQ-IMVGVFERVYEVAPVWRMEEHHTSRHLNEYLSLDVEMGFIADEED 229 Query: 350 LMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLP 409 LM + E +++ M++ + G A F R+ E Sbjct: 230 LMRLEEALLAEMLEEALNTAGDEIRLLG----ATWPSFPQDIPRLTHAEA---------- 275 Query: 410 ETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFL-EVTCINPTFICDHPQI 468 ++IL + + P + + ++L+GE+ E + F+ +P+ Sbjct: 276 ----------KRILKE-----ELGYPVGQDLSEEAERLLGEYAKERWGSDWLFVTRYPRS 320 Query: 469 MSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMF 528 + P + G T F+L EI + ++ R +L E KA G D F Sbjct: 321 VRPFYTYPEED-GTTRSFDLLFRGLEITSGGQRIH---RYEELLESL---KAKGMDPEAF 373 Query: 529 IDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMK 574 + +YG+PP G+ +G +R+ L N++ FP + Sbjct: 374 --HGYLEVFKYGMPPHGGFAIGAERLTQKLLGLPNVRYARAFPRDR 417 >4WJ3-M nrPDB Length = 599 Score = 318 bits (815), Expect = 4e-87, Method: Composition-based stats. Identities = 106/559 (18%), Positives = 198/559 (35%), Gaps = 112/559 (20%) Query: 116 QPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNK 175 Q + L + + G +H +R GG +IF D+R QV+ + E ++ Sbjct: 17 QLNESLDGQEVTLCGWVHRRRDHGG-VIFLDVRDREGLAQVVFDPD----RAETFAKADR 71 Query: 176 LRRGDIIGVQGNPG---------KTKKGELSIIPYEITLLSPC-LHMLPHLHFGLKDKET 225 +R ++ + G G + ++ YE+ +L+ P + +ET Sbjct: 72 VRSEFVVKITGKVRLRPEGARNPNMASGSIEVLGYELEVLNQAETPPFPLDEYSDVGEET 131 Query: 226 RYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFIT 285 R R R++DL + K +R++I + IR +LD+ GFL++ETP++ + Sbjct: 132 RLRYRFIDLRRPEMA-AKLKLRARITSSIRRYLDDNGFLDVETPILGRPTPEGARDYLVP 190 Query: 286 YHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYA 345 + +P+L+ ++L+V G DR Y+I + FR+E + PEFT + ++ Sbjct: 191 SRTYPGHFFALPQSPQLFKQLLMVAGFDRYYQIAKCFRDEDLRADRQPEFTQIDIETSFL 250 Query: 346 DYHDL-------------------------MEITEKM----------------------- 357 D D+ M E M Sbjct: 251 DESDIIGITEKMVRQLFKEVLDVEFDEFPHMPFEEAMRRYGSDKPDLRIPLELVDVADQL 310 Query: 358 -------VSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPF------RRINMVEELEKAL 404 SG G P +D F + + ++ E+A Sbjct: 311 KEVEFKVFSGPANDPKGRVAALRVPGAASMPRSQIDDYTKFVGIYGAKGLAYIKVNERAK 370 Query: 405 GMK---LPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEF---------L 452 G++ P ILD + A+++ +G L Sbjct: 371 GVEGLQSPIVKFIPEANLNVILDRVGAVDGDIVFFGADKAKIVCDALGALRIKVGHDLKL 430 Query: 453 EVTCINPTFICDHPQIM-------------------SPLAKWHRSKEGLTERFELFVMKK 493 P ++ D P +P L+ +++ + Sbjct: 431 LTREWAPMWVVDFPMFEENDDGSLSALHHPFTSPKCTPAELEANPGAALSRAYDMVLNGT 490 Query: 494 EICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDR 553 E+ ++D Q+ +F +A +++ F+ AL+YG PP G G+DR Sbjct: 491 ELGGGSIRIHDKSMQQAVFRVLGIDEAEQEEKFGFL----LDALKYGAPPHGGLAFGLDR 546 Query: 554 VAMFLTDSNNIKEVLLFPA 572 + M +T +++I+EV+ FP Sbjct: 547 LVMLMTGASSIREVIAFPK 565 >1IL2-A nrPDB Length = 590 Score = 303 bits (775), Expect = 2e-82, Method: Composition-based stats. Identities = 110/556 (19%), Positives = 201/556 (36%), Gaps = 118/556 (21%) Query: 122 TDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDI 181 + + G ++ +R G LIF D+R +QV + + + + ++LR Sbjct: 14 VGQQVTLCGWVNRRRDLGS-LIFIDMRDREGIVQVFFDPD----RADALKLASELRNEFC 68 Query: 182 IGVQGNPGK---------TKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYL 232 I V G GE+ ++ +T+++ +LP + +E R + RYL Sbjct: 69 IQVTGTVRARDEKNINRDMATGEIEVLASSLTIINRA-DVLPLDSNHVNTEEARLKYRYL 127 Query: 233 DLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMN-IIPGGAVAKPFITYHNELD 291 DL + Q+ R+KI + +R F+D+ GFL+IETPM+ P GA + ++ Sbjct: 128 DLRRPEMA-QRLKTRAKITSLVRRFMDDHGFLDIETPMLTKATPEGA--RDYLVPSRVHK 184 Query: 292 MNLY-MRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEF--------------- 335 Y + +P+L+ ++L++ G DR Y+I + FR+E + PEF Sbjct: 185 GKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMTAPQV 244 Query: 336 --------------------------TTCEFY-------------MAYADYHDLMEITE- 355 T E M D DL++ E Sbjct: 245 REVMEALVRHLWLEVKGVDLGDFPVMTFAEAERRYGSDKPDLRNPMELTDVADLLKSVEF 304 Query: 356 KMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRIN------MVEELEKALGMK-- 407 + +G G P G +D F +I ++ E+A G++ Sbjct: 305 AVFAGPANDPKGRVAALRVPGGASLTRKQIDEYGNFVKIYGAKGLAYIKVNERAKGLEGI 364 Query: 408 -LPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEF----------LEVTC 456 P E ILD +++ +G + + Sbjct: 365 NSPVAKFLNAEIIEDILDRTAAQDGDMIFFGADNKKIVADAMGALRLKVGKDLGLTDESK 424 Query: 457 INPTFICDHP--------------------QIMSPLAKWHRSKEGLTERFELFVMKKEIC 496 P ++ D P + M+ + + +++ + E+ Sbjct: 425 WAPLWVIDFPMFEDDGEGGLTAMHHPFTSPKDMTAAELKAAPENAVANAYDMVINGYEVG 484 Query: 497 NAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAM 556 +++ Q+ +F ++E AL+YG PP AG G+DR+ M Sbjct: 485 GGSVRIHNGDMQQTVFGIL----GINEEEQREKFGFLLDALKYGTPPHAGLAFGLDRLTM 540 Query: 557 FLTDSNNIKEVLLFPA 572 LT ++NI++V+ FP Sbjct: 541 LLTGTDNIRDVIAFPK 556 >3I7F-A nrPDB Length = 548 Score = 296 bits (757), Expect = 2e-80, Method: Composition-based stats. Identities = 83/363 (22%), Positives = 146/363 (40%), Gaps = 46/363 (12%) Query: 216 LHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIP 275 + ++TR R LDL + F I+S R FL F+EI TP + I Sbjct: 217 QKYVKVSQDTRLDNRMLDLRTVTNI-AIFRIQSACCGLFREFLTSQKFVEIHTPKL--IG 273 Query: 276 GGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDL-THNPE 334 + I D Y+ +P+LY +M ++G +V+E+G FR E + H E Sbjct: 274 CSSEGGSNIFEVKYFDRKAYLAQSPQLYKQMAIMGDFRKVFEVGPVFRAENSNTRRHLTE 333 Query: 335 FTTCEFYMAYAD-YHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRR 393 F + M + YH+ +++ EK+ + + I + + D+ + PF R Sbjct: 334 FEGLDIEMEIVENYHECIDVMEKLFTFIFDEIPKRFPDELKVIRKQYPFEDLIYR-PFLR 392 Query: 394 INMVEELE--KALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEF 451 + E +E +A G + + + F T + K +GE Sbjct: 393 LTYKEAIEMLRASGETIGDYDDFTTPQEVK--------------------------LGEL 426 Query: 452 LEVTCINPTFICD-HPQIMSPLAKWHR-SKEGLTERFELFVMKKEICNAYTELNDPM-RQ 508 ++ +I D P + P + +++FV +EI + ++DP Sbjct: 427 IKAKYNTDFYILDKFPAAIRPFYTMPDIDDPNYSNSYDVFVRGQEITSGAQRIHDPEFLM 486 Query: 509 RQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVL 568 ++ E+ G D A D + + +G P AG G+G++R+ M NI++V Sbjct: 487 KRCIEK-------GVDPATLKD--YIESFRFGSWPHAGCGIGLERITMLYLGIPNIRKVT 537 Query: 569 LFP 571 LFP Sbjct: 538 LFP 540 >1X54-A nrPDB Length = 434 Score = 287 bits (734), Expect = 8e-78, Method: Composition-based stats. Identities = 86/468 (18%), Positives = 166/468 (35%), Gaps = 70/468 (14%) Query: 120 HLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRG 179 L +++AG ++ G K IF +R +Q + EE KL R Sbjct: 13 ELDGKKVRLAGWVYTNMRVGKK-IFLWIRDSTGIVQAVVAKNVVG--EETFEKAKKLGRE 69 Query: 180 DIIGVQGNPGKTKK--GELSIIPYEITLLSPCLH-MLPHLHFGLKDKETRYRQRYLDLIL 236 + V+G ++ G + ++ ++ +P E R+L I Sbjct: 70 SSVIVEGIVKADERAPGGAEVHVEKLEVIQAVSEFPIPENP-EQASPELLLDYRHLH-IR 127 Query: 237 NDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYM 296 ++ +I R +L + G+ E+ P++ + G + D Y+ Sbjct: 128 TPKASAIMKVKETLIMAAREWLLKDGWHEVFPPIL--VTGAVEGGATLFKLKYFDKYAYL 185 Query: 297 RIAPELYHKMLVVGGIDRVYEIGRQFRNE-GIDLTHNPEFTTCEFYMAYADYHDLMEITE 355 + +LY + + G+++V+ + FR E H EF E A+ D D+M++ E Sbjct: 186 SQSAQLYLEAAIF-GLEKVWSLTPSFRAEKSRTRRHLTEFWHLELEAAWMDLWDIMKVEE 244 Query: 356 KMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFE 415 ++VS MV+ K + + PPF RI+ E + Sbjct: 245 ELVSYMVQRTLELRKKEIEMFRDDLTTLK-NTEPPFPRISYDEAI--------------- 288 Query: 416 TEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKW 475 DI +K V ++++ E + P F+ +P+ Sbjct: 289 ---------DILQSKGVNVEWGDDLGADEERVLTEEFD----RPFFVYGYPK-------- 327 Query: 476 HRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFID----- 530 + F MK++ + L M + + E DD ++ Sbjct: 328 ---------HIKAFYMKEDPNDPRKVLASDMLAPEGYGEIIGGSQREDDYDKLLNRILEE 378 Query: 531 -------ENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 E + YG P +G+G+G++R+ ++ ++I+ LFP Sbjct: 379 GMDPKDYEWYLDLRRYGSVPHSGFGLGVERLVAWVLKLDHIRWAALFP 426 >3A5Z-A nrPDB Length = 328 Score = 280 bits (716), Expect = 1e-75, Method: Composition-based stats. Identities = 89/349 (25%), Positives = 148/349 (42%), Gaps = 44/349 (12%) Query: 237 NDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGG-----AVAKPFITYHNELD 291 + R+ I+ IR F + G LE+ETP M+ F+ + Sbjct: 12 PSASIPNLLKRAAIMAEIRRFFADRGVLEVETPCMSQATVTDIHLVPFETRFVGPGHSQG 71 Query: 292 MNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLM 351 MNL++ +PE + K L+V G V+++ R FRNE + HNPEFT E+Y + D + LM Sbjct: 72 MNLWLMTSPEYHMKRLLVAGCGPVFQLCRSFRNEEMGRYHNPEFTMLEWYRPHYDMYRLM 131 Query: 352 EITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELE------KALG 405 + ++ ++ A + + F R ++ L + + Sbjct: 132 NEVDDLLQQVLD---------------CPAAESLSYQQAFLRYLEIDPLSADKTQLREVA 176 Query: 406 MKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDH 465 KL +N+ +TEE R L + VE + PTF+ Sbjct: 177 AKLDLSNVADTEEDRDTLLQLLFTFGVEPNIGK------------------EKPTFVYHF 218 Query: 466 PQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDE 525 P + LA+ + ERFE++ E+ N + EL D Q+Q FE+ + +AA Sbjct: 219 PASQASLAQISTEDHRVAERFEVYYKGIELANGFHELTDAREQQQRFEQDNRKRAARGLP 278 Query: 526 AMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMK 574 ID+N AL+ G+P +G +G+DR+ M + + EV+ F + Sbjct: 279 QHPIDQNLIEALKVGMPDCSGVALGVDRLVMLALGAETLAEVIAFSVDR 327 >3G1Z-A nrPDB Length = 326 Score = 279 bits (712), Expect = 3e-75, Method: Composition-based stats. Identities = 89/349 (25%), Positives = 147/349 (42%), Gaps = 44/349 (12%) Query: 237 NDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGG-----AVAKPFITYHNELD 291 + R+ I+ IR F + G LE+ETP M+ F+ + Sbjct: 10 PSASIPNLLKRAAIMAEIRRFFADRGVLEVETPCMSQATVTDIHLFPFETRFVGPGHSQG 69 Query: 292 MNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLM 351 +NLY+ +PE + K L+ G V+++ R FRNE + HNPEFT E+Y + D + LM Sbjct: 70 INLYLMTSPEYHMKRLLAAGCGPVFQLCRSFRNEEMGRHHNPEFTMLEWYRPHYDMYRLM 129 Query: 352 EITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELE------KALG 405 + ++ ++ A + + F+R ++ L + Sbjct: 130 NEVDDLLQQVLD---------------CQPAESLSYQQAFQRHLEIDPLSADKTQLREAA 174 Query: 406 MKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDH 465 KL +N+ +TEE R L + VE + PTFI Sbjct: 175 AKLDLSNIADTEEDRDTLLQLLFTMGVEPHIGK------------------EKPTFIYHF 216 Query: 466 PQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDE 525 P + LA+ + ERFE++ E+ N + EL D Q+Q FE+ + +AA Sbjct: 217 PASQASLAQISTEDHRVAERFEVYYKGIELANGFHELTDAREQQQRFEQDNRKRAARGLP 276 Query: 526 AMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMK 574 ID+N AL GLP +G +G+DR+ M + ++ +V+ F + Sbjct: 277 QQPIDQNLLDALAAGLPDCSGVALGVDRLVMLALGAESLADVIAFTVDR 325 >5W25-A nrPDB Length = 616 Score = 258 bits (659), Expect = 5e-69, Method: Composition-based stats. Identities = 80/329 (24%), Positives = 140/329 (42%), Gaps = 47/329 (14%) Query: 115 LQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINN 174 L+ GD + +AG + +R GG +IF DLR QV+ + E + + Sbjct: 32 LREGDAGQQ--VTLAGWVARRRDHGG-VIFIDLRDASGIAQVVFRD---PQDTEVLAQAH 85 Query: 175 KLRRGDIIGVQGNPG---------KTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKET 225 +LR + V G + GE+ + +T+L C LP +E Sbjct: 86 RLRAEFCVSVAGVVEIRPEGNANPEIATGEIEVNATSLTVLGECA-PLPFQLDEPAGEEL 144 Query: 226 RYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMN-IIPGGAVAKPFI 284 R + RYLDL +D +RS++ R+ L F+EIETP + P GA + F+ Sbjct: 145 RLKYRYLDLRRDDPA-AAIRLRSRVNAAARAVLARHDFVEIETPTITRSTPEGA--RDFL 201 Query: 285 TYHNELDMNLY-MRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMA 343 + Y + +P+L+ ++L+V G++R Y+I R +R+E PEFT + M+ Sbjct: 202 VPARLHPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDMEMS 261 Query: 344 YADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEK- 402 + D D++ I+E++++ + I P RI E + + Sbjct: 262 FVDAEDIIAISEEVLTELWALI------------------GYRIPTPIPRIGYAEAMRRF 303 Query: 403 -------ALGMKLPETNLFETEETRKILD 424 G++L E F ++ T ++ Sbjct: 304 GTDKPDLRFGLELVECTDFFSDTTFRVFQ 332 Score = 116 bits (291), Expect = 2e-26, Method: Composition-based stats. Identities = 29/125 (23%), Positives = 50/125 (40%), Gaps = 9/125 (7%) Query: 453 EVTCINPTFICDHPQIMSPLAKWHRSKEG-----LTERFELFVMKKEICNAYTELNDPMR 507 EV + + H +P +W E L + +++ EI ++ Sbjct: 461 EVAVGSGAWTAVHHAFTAPKPEWEDRIESDTGSVLADAYDIVCNGHEIGGGSVRIHRRDI 520 Query: 508 QRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEV 567 Q ++F KA +++ F+ E F +G PP G G DR L ++I+EV Sbjct: 521 QERVFAVMGLDKAEAEEKFGFLLEAFM----FGAPPHGGIAFGWDRTTALLAGMDSIREV 576 Query: 568 LLFPA 572 + FP Sbjct: 577 IAFPK 581 >4RMF-A nrPDB Length = 609 Score = 258 bits (658), Expect = 6e-69, Method: Composition-based stats. Identities = 79/315 (25%), Positives = 134/315 (42%), Gaps = 43/315 (13%) Query: 110 QKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEF 169 L+P D T+ +AG + +R GG +IF DLR QV+ E + Sbjct: 5 HAAGSLRPADAGQ--TVTLAGWVARRRDHGG-VIFIDLRDASGVSQVVFR------EGDV 55 Query: 170 IHINNKLRRGDIIGVQGNPG---------KTKKGELSIIPYEITLLSPCLHMLPHLHFGL 220 + ++LR + V G + G++ + E+T+L LP Sbjct: 56 LAAAHRLRAEFCVAVTGVVEVRPEGNENPEIPTGQIEVNATELTVLGESA-PLPFQLDEQ 114 Query: 221 KDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMN-IIPGGAV 279 +E R + RYLDL + +RSK+ RS L E F+EIETP + P GA Sbjct: 115 AGEEARLKYRYLDLRR-EGPGNALRLRSKVNAAARSVLAEHDFVEIETPTLTRSTPEGA- 172 Query: 280 AKPFITYHNELDMNLY-MRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTC 338 + F+ + Y + +P+L+ ++L+V G++R Y+I R +R+E PEFT Sbjct: 173 -RDFLVPARLQPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQL 231 Query: 339 EFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVE 398 + M++ + D++ I+E+++ + I D P RI+ E Sbjct: 232 DMEMSFVEADDVIAISEQVLKAVWATI------------------GYDLPLPLPRISYEE 273 Query: 399 ELEKALGMKLPETNL 413 + + G P+ Sbjct: 274 AM-RRFGSDKPDLRF 287 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 24/125 (19%), Positives = 45/125 (36%), Gaps = 9/125 (7%) Query: 453 EVTCINPTFICDHPQIMSPLAK-----WHRSKEGLTERFELFVMKKEICNAYTELNDPMR 507 +V + + H +P L++ +++ EI ++ Sbjct: 436 DVAVGSGAWTAMHHAFTAPKPDSVDTFDSDPGNALSDAYDIVCNGNEIGGGSIRIHRRDI 495 Query: 508 QRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEV 567 Q ++F ++ F+ A YG PP G G DR+ L ++I+EV Sbjct: 496 QERVFAMMGIDHDEAQEKFGFL----LDAFSYGAPPHGGIAFGWDRITALLAGVDSIREV 551 Query: 568 LLFPA 572 + FP Sbjct: 552 IAFPK 556 >2XGT-A nrPDB Length = 435 Score = 248 bits (632), Expect = 6e-66, Method: Composition-based stats. Identities = 83/467 (17%), Positives = 163/467 (34%), Gaps = 68/467 (14%) Query: 123 DITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDII 182 + + + G IH R G L+F+ LR LQV+ + ++ + + + Sbjct: 11 NERVCIKGWIHRMRRQGKSLMFFILRDGTGFLQVLLMDKLCQTYDAL-----TVNTECTV 65 Query: 183 GVQGNPGKTKKG-------ELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLI 235 + G + +G EL ++I +P + ++ + R+L +I Sbjct: 66 EIYGAIKEVPEGKEAPNGHELIADFWKIIGNAP-PGGIDNVLNEEASVDKMLDNRHL-VI 123 Query: 236 LNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMM--NIIPGGAVAKPFITYHNELDMN 293 + +R+ +R G++E+ P + + GG+ + + Sbjct: 124 RGENAAALLRLRAAATRAMREHFYNAGYVEVAPPTLVQTQVEGGST----LFNLDYFGEQ 179 Query: 294 LYMRIAPELYHKMLVVGGIDRVYEIGRQFRNE-GIDLTHNPEFTTCEFYMAYADYHDLME 352 ++ + +LY + + + V+ I + +R E H E+ E + DLME Sbjct: 180 SFLTQSSQLYLETCI-PTLGDVFCIAQSYRAEKSRTRRHLAEYAHVEAECPFITLDDLME 238 Query: 353 ITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPP---FRRINMVEELEKALGMKLP 409 E++V V + + + F PP F R+ + ++ Sbjct: 239 KIEELVCDTVDRLLAD-----EEAKKLLEHINPKFQPPERPFLRMEYKDAIK-------- 285 Query: 410 ETNLFETEETRKILDDICVAKAVECPPPRTTARLLD--KLVGEFLEVTCINPTFICDHPQ 467 VE T D + F+ T P + P Sbjct: 286 ----------------WLQEHNVENEFGNTFTYGEDIAEAAERFMTDTINKPILLNRFPS 329 Query: 468 IMSPLA-KWHRSKEGLTERFELFVMKK-EICNAYTELNDPMRQRQLFEEQAKA-KAAGDD 524 + + LTE +L + EI + F+E +KA K D Sbjct: 330 EIKAFYMQRDAQDNTLTESVDLLMPGVGEIVGGSMRI-------WKFDELSKAFKNVEID 382 Query: 525 EAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 + + YG P G+G+G++R +LT++N+I++V L+P Sbjct: 383 PKPYY--WYLDQRLYGTCPHGGYGLGLERFICWLTNTNHIRDVCLYP 427 >3M4P-A nrPDB Length = 456 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 76/468 (16%), Positives = 167/468 (35%), Gaps = 50/468 (10%) Query: 114 HLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHIN 173 +++ L + G + R + LIF +LR Q + + E+ + Sbjct: 21 NIRDAAGLEGKLVTFKGWAYHIRKARKTLIFVELRDGSGYCQCVIFGKELCEPEKVKLLT 80 Query: 174 NKLRRGDIIGVQGNPGKTKKGE------LSIIPYEITLLSPCLHMLPHLHFGLKDKETRY 227 + + GK E L + E ++ L ++ + Sbjct: 81 RECSLEITGRLNAYAGKNHPPEIADILNLEMQVTEWKVIGESPIDLENIINKDSSIPQKM 140 Query: 228 RQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYH 287 + R++ +I ++ +Q +RS+I Y R + + F EI+ P + + + Sbjct: 141 QNRHI-VIRSEHTQQVLQLRSEIQWYFRKYYHDNHFTEIQPPTIVKTQCEGGST--LFKL 197 Query: 288 NELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDL-THNPEFTTCEFYMAYAD 346 + Y+ + +LY + V+ + + + + +R E H E+ E + + Sbjct: 198 QYFNEPAYLTQSSQLYLES-VIASLGKSFCMLSSYRAEQSRTVRHLAEYLHLEAELPFIS 256 Query: 347 YHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGM 406 + DL+ E +V ++ ++ + P + T PF+R+ + ++ Sbjct: 257 FEDLLNHLEDLVCTVIDNVMAVHGDKIRKMNPHLKLP----TRPFKRMTYADAIK----- 307 Query: 407 KLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHP 466 + + ++ + +DI + + P F+ P Sbjct: 308 YCNDHGILNKDKPFEYGEDIS------------------EKPERQMTDEIGCPIFMIHFP 349 Query: 467 QIMSPLA-KWHRSKEGLTERFELFVMKK-EICNAYTELNDPMRQRQLFEEQAKA-KAAGD 523 M LTE +L + EI + ++E A KA G Sbjct: 350 SKMKAFYMSKVPGHPDLTESVDLLMPGVGEIVGGSMRI-------WNYDELMGAYKANGL 402 Query: 524 DEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 + + + +YG P G+G+G++R+ M+L ++I++V L+P Sbjct: 403 NPDPYY--WYTQQRKYGSCPHGGYGLGVERLVMWLLGEDHIRKVCLYP 448 >1EFW-A nrPDB Length = 580 Score = 221 bits (563), Expect = 6e-58, Method: Composition-based stats. Identities = 67/362 (18%), Positives = 149/362 (41%), Gaps = 43/362 (11%) Query: 100 HVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMA- 158 + + + + G ++ +R GG LIF DLR +Q++A Sbjct: 2 RRTHYAGSLRETH---------VGEEVVLEGWVNRRRDLGG-LIFLDLRDREGLVQLVAH 51 Query: 159 NSRNYKSEEEFIHINNKLRRGDIIGVQGNPG-KTKKGELSIIPYEITLLSPCLHMLPHLH 217 + + E + +R ++ ++ P + G + + + +L+ + Sbjct: 52 PASPAYATAERVRPEWVVRAKGLVRLRPEPNPRLATGRVEVELSALEVLAEAKTPPFPVD 111 Query: 218 FGLKDKETRYRQRYLDL------ILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMM 271 G + +E + L L + +++ +R ++I I FLD GF+++ETP + Sbjct: 112 AGWRGEEEKEASEELRLKYRYLDLRRRRMQENLRLRHRVIKAIWDFLDREGFVQVETPFL 171 Query: 272 NIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTH 331 + Y +E + + +P+L+ +ML+V G+DR ++I R FR+E + Sbjct: 172 TKSTPEGARDFLVPYRHEPGLFYALPQSPQLFKQMLMVAGLDRYFQIARCFRDEDLRADR 231 Query: 332 NPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPF 391 P+FT + M++ + D++E+ E++++ + + G V+ PF Sbjct: 232 QPDFTQLDLEMSFVEVEDVLELNERLMAHVFREALG-----------------VELPLPF 274 Query: 392 RRINMVEELEKA--------LGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARL 443 R++ E +E+ G++L E + ++ + KA+ P + + Sbjct: 275 PRLSYEEAMERYGSDKPDLRFGLELKEVGPLFRQSGFRVFQEAESVKALALPKALSRKEV 334 Query: 444 LD 445 + Sbjct: 335 AE 336 Score = 120 bits (300), Expect = 2e-27, Method: Composition-based stats. Identities = 39/150 (26%), Positives = 62/150 (41%), Gaps = 6/150 (4%) Query: 425 DICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTE 484 D+ K L + E T ++ F HP+ + L K L Sbjct: 409 DLLGLKREGFRFLWVVDFPLLEWDEEEEAWTYMHHPFTSPHPEDLPLLEKDPGRVRALA- 467 Query: 485 RFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPT 544 ++L + E+ ++DP Q ++F + G++E F ALEYG PP Sbjct: 468 -YDLVLNGVEVGGGSIRIHDPRLQARVF----RLLGIGEEEQREKFGFFLEALEYGAPPH 522 Query: 545 AGWGMGIDRVAMFLTDSNNIKEVLLFPAMK 574 G G+DR+ +T S +I+EV+ FP K Sbjct: 523 GGIAWGLDRLLALMTGSPSIREVIAFPKNK 552 >4AH6-A nrPDB Length = 617 Score = 218 bits (555), Expect = 5e-57, Method: Composition-based stats. Identities = 69/319 (21%), Positives = 122/319 (38%), Gaps = 31/319 (9%) Query: 123 DITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDII 182 + + G I +R + F LR +QV+ + I + ++ Sbjct: 24 GQEVTLCGWIQYRRQN----TFLVLRDFDGLVQVIIPQDESAA--SVKKILCEAPVESVV 77 Query: 183 GVQGNPG---------KTKKGELSIIPYEITLLSPCLH-MLPHLHFGLKDKETRYRQRYL 232 V G K GE+ I LL+ C +F K + R + RYL Sbjct: 78 QVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEALRLQYRYL 137 Query: 233 DLILNDFVRQKFIIRSKIITYIRSFLDE-LGFLEIETPMM-NIIPGGAVAKPFITYHNEL 290 DL + ++ +RS+++ +R +L GF++IETP + PGGA K F+ E Sbjct: 138 DL-RSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGA--KEFLVPSREP 194 Query: 291 DMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDL 350 + +P+ + ++L+VGG+DR +++ R +R+EG PEFT + M++ D + Sbjct: 195 GKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGI 254 Query: 351 MEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPE 410 + E ++ + V + P R GMK+ + Sbjct: 255 QSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTR----------FGMKIID 304 Query: 411 TNLFETEETRKILDDICVA 429 + L D Sbjct: 305 ISDVFRNTEIGFLQDALSK 323 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 29/120 (24%), Positives = 54/120 (45%), Gaps = 9/120 (7%) Query: 453 EVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLF 512 E+ + F HP + L K+ ++ ++L + EI +++ QR + Sbjct: 457 ELESAHHPFTAPHPSDIHLLYT--EPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYIL 514 Query: 513 EEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPA 572 K E + + + AL+YG PP G +G+DR+ +T S +I++V+ FP Sbjct: 515 ATLLK-------EDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPK 567 >5ZG8-A nrPDB Length = 438 Score = 208 bits (528), Expect = 8e-54, Method: Composition-based stats. Identities = 81/461 (17%), Positives = 156/461 (33%), Gaps = 49/461 (10%) Query: 122 TDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDI 181 D +++ G ++ +R+ G K+ F LR LQ E + L + Sbjct: 12 VDQEVELRGWLYQRRSKG-KIHFLILRDGTGFLQATVVQGEV--PEAVFREADHLPQETA 68 Query: 182 IGVQGNPGKTKK--GELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDF 239 + V G + ++ G + ++ ++S P + R+L L Sbjct: 69 LRVWGRVREDRRAPGGFELAVRDLQVVSRPQGEYPIGPKE-HGIDFLMDHRHLWLRHR-R 126 Query: 240 VRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMN-LYMRI 298 IR ++ I F E GFL + P++ P + D Y+ Sbjct: 127 PFAVMRIRDELERAIHEFFGERGFLRFDAPILT--PSAVEGTTELFEVELFDGEKAYLSQ 184 Query: 299 APELYHKMLVVGGIDRVYEIGRQFRNE-GIDLTHNPEFTTCEFYMAYADYHDLMEITEKM 357 + +LY + + +VY G FR E H EF E +A+ + + M + E++ Sbjct: 185 SGQLYAEAGALA-FAKVYTFGPTFRAERSKTRRHLLEFWMVEPEVAFMTHEENMALQEEL 243 Query: 358 VSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEE--LEKALGMKLPETNLFE 415 VS +V + G + +A + + R+ E L + + PE Sbjct: 244 VSFLVARVLERRSRELEMLGRDPKALEPAAEGHYPRLTYKEAVALVNRIAQEDPEVPPLP 303 Query: 416 TEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHP-QIMSPLAK 474 E D L P F+ +P +I + + Sbjct: 304 YGE------DFGAPHEAA------------------LSRRFDRPVFVERYPARIKAFYME 339 Query: 475 WHRSKEGLTERFELFVMKK--EICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDEN 532 L +L + EI ++D R+ +E + + Sbjct: 340 PDPEDPELVLNDDLLAPEGYGEIIGGSQRIHDLELLRRKIQEFGL--------PEEVYDW 391 Query: 533 FCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAM 573 + +G P +G+G+G++R ++ +++E + FP M Sbjct: 392 YLDLRRFGSVPHSGFGLGLERTVAWICGLAHVREAIPFPRM 432 >3P8T-A nrPDB Length = 294 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 66/349 (18%), Positives = 137/349 (39%), Gaps = 77/349 (22%) Query: 235 ILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNL 294 I++ + + I++KI+ Y+ F + GF + M++ I P ++++ Sbjct: 6 IISRDIYKAIDIQTKILDYMTKFFTDRGFKWLLPIMLSPITDPLWPDPAGEGIRPAEVDV 65 Query: 295 Y---MRIAPE--LYHKMLVVGGIDRVYEIGRQFRNEGI---DLTHNPEFTTCEFYMAYAD 346 Y MR+ L+ ++ + G+++++ + R E D H+ EFT +F + A Sbjct: 66 YGVRMRLTHSMILHKQLAIAMGLEKIFVLSPNIRLESRRKDDGRHSYEFTQLDFEIEGAK 125 Query: 347 YHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGM 406 D+M + E+++ G+ + E+ G Sbjct: 126 MKDVMRLIEELIYGLFRKA-----------------------------------EEWTGR 150 Query: 407 KLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHP 466 + P F+ + + IL++ E + P +I + P Sbjct: 151 EFPRARHFKVYDYKDILEEFGS--------------------DEKASMEMEEPFWIVNIP 190 Query: 467 QIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQ-AKAKAAGDDE 525 + + R + G+ + ++L + Y E++ + +E+ AK +AAG E Sbjct: 191 REF-----YDREENGVWKNYDLI-----LPYGYGEVSSGGEREWEYEKIVAKIRAAGLKE 240 Query: 526 AMFIDENFCTALEYG-LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAM 573 F + G L P+AG G+G++R+ F+ + +I EV FP + Sbjct: 241 DSFRP--YLEIARAGKLKPSAGAGIGVERLVRFIVGAKHIAEVQPFPRV 287 >1NNH-A nrPDB Length = 294 Score = 200 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 67/349 (19%), Positives = 132/349 (37%), Gaps = 77/349 (22%) Query: 235 ILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNL 294 I++ + I++KI+ Y+ F + GF + +++ I P ++ + Sbjct: 6 IISREISPTLDIQTKILEYMTDFFVKEGFKWLLPVIISPITDPLWPDPAGEGMEPAEVEI 65 Query: 295 Y---MRIAPE--LYHKMLVVGGIDRVYEIGRQFRNEGI---DLTHNPEFTTCEFYMAYAD 346 Y MR+ L+ ++ + G+ +++ + R E D H EFT +F + A Sbjct: 66 YGVKMRLTHSMILHKQLAIAMGLKKIFVLSPNIRLESRQKDDGRHAYEFTQLDFEVERAK 125 Query: 347 YHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGM 406 D+M + E++V G+ + E+ G Sbjct: 126 MEDIMRLIERLVYGLFRKA-----------------------------------EEWTGR 150 Query: 407 KLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHP 466 + P+T FE E ++L++ E P +I + P Sbjct: 151 EFPKTKRFEVFEYSEVLEEFGS--------------------DEKASQEMEEPFWIINIP 190 Query: 467 QIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQ-AKAKAAGDDE 525 + + R +G ++L + Y E+ + +E+ AK + AG +E Sbjct: 191 REF-----YDREVDGFWRNYDLI-----LPYGYGEVASGGEREWEYEKIVAKIRKAGLNE 240 Query: 526 AMFIDENFCTALEYG-LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAM 573 F + + G L P+AG G+G++R+ F+ + +I EV FP + Sbjct: 241 DSFRP--YLEIAKAGKLKPSAGAGIGVERLVRFIVGAKHIAEVQPFPRI 287 >3VQX-A nrPDB Length = 291 Score = 63.7 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 37/178 (20%), Positives = 68/178 (38%), Gaps = 17/178 (9%) Query: 174 NKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLD 233 + RG + K++ L + LL+P + + ++ E+ R Sbjct: 13 GLVPRGSHMASAPALTKSQTDRLEV------LLNPKDEISLNSGKPFRELESELLSRRKK 66 Query: 234 LILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIP-----GGAVAKPFITYHN 288 + + ++ K+ I F + GFLEI++P++ + G Sbjct: 67 DLQQIYAEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMGIDNDTELSKQIF 126 Query: 289 ELDMNLYMR--IAPELY--HKML--VVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEF 340 +D N +R +AP LY + L + +++EIG +R E H EFT F Sbjct: 127 RVDKNFCLRPMLAPNLYNYLRKLDRALPDPIKIFEIGPCYRKESDGKEHLEEFTMLNF 184 >5GRO-A nrPDB Length = 115 Score = 57.6 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 20/103 (19%), Positives = 44/103 (42%), Gaps = 15/103 (14%) Query: 116 QPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNK 175 + + +KVAG + R GG ++F DLR + +Q++ + + E+ + Sbjct: 19 EISEKDVGKIVKVAGWCNTYRDHGG-VVFIDLRDKSGLVQLVCDPSSKAYEKAL-----E 72 Query: 176 LRRGDIIGVQGNPG---------KTKKGELSIIPYEITLLSPC 209 +R ++ +G K K G++ I+ E+ + + Sbjct: 73 VRSEFVLVAKGKVRLRGAGLENPKLKTGKIEIVLEELIIENKS 115 >6JP2-A nrPDB Length = 278 Score = 53.7 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 35/150 (23%), Positives = 59/150 (39%), Gaps = 19/150 (12%) Query: 248 SKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLY-------MR--I 298 ++++ I L GF+E+ TP+ I A+A+ IT L ++ +R + Sbjct: 67 TQLMNDIADALVAEGFIEVRTPIF--ISKDALARMTITEDKPLFKQVFWIDEKRALRPML 124 Query: 299 APELYHKMLVV----GGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEIT 354 AP LY M + G +++E+G FR E H EFT D + T Sbjct: 125 APNLYSVMRDLRDHTDGPVKIFEMGSCFRKESHSGMHLEEFTMLNL----VDMGPRGDAT 180 Query: 355 EKMVSGMVKHITGSYKVTYHPDGPEGQAYD 384 E + + + + + Y E Y Sbjct: 181 EVLKNYISVVMKAAGLPDYDLVQEESDVYK 210 >2ZNJ-A nrPDB Length = 308 Score = 52.9 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 32/150 (21%), Positives = 55/150 (36%), Gaps = 18/150 (12%) Query: 229 QRYLDLILNDFVR-QKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAK-----P 282 +R+L+ + R + K+ L + GF+++ TP + A P Sbjct: 78 KRHLEQLRTVKHRPALLELEEKLAKA----LHQQGFVQVVTPTIITKSALAKMTIGEDHP 133 Query: 283 FITYHNELDMNLYMR--IAPELY-----HKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEF 335 + LD +R +AP LY + L I R++EIG +R E H EF Sbjct: 134 LFSQVFWLDGKKCLRPMLAPNLYTLWRELERLWDKPI-RIFEIGTCYRKESQGAQHLNEF 192 Query: 336 TTCEFYMAYADYHDLMEITEKMVSGMVKHI 365 T + + E M +++ Sbjct: 193 TMLNLTELGTPLEERHQRLEDMARWVLEAA 222 Score = 31.7 bits (70), Expect = 0.89, Method: Composition-based stats. Identities = 28/202 (13%), Positives = 62/202 (30%), Gaps = 52/202 (25%) Query: 416 TEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDH---------P 466 ++ + + A + T ++ K + + +P F P Sbjct: 90 RPALLELEEKLAKALHQQGFVQVVTPTIITKSALAKMTIGEDHPLFSQVFWLDGKKCLRP 149 Query: 467 QIMSPLAKWHRSKEGLTER----FELFVMKKEICNAYTELND------------PMRQRQ 510 + L R E L ++ FE+ ++ LN+ + Q Sbjct: 150 MLAPNLYTLWRELERLWDKPIRIFEIGTCYRKESQGAQHLNEFTMLNLTELGTPLEERHQ 209 Query: 511 LFEEQAK--AKAAGDDEAMFIDEN---FCTALEY----------GLPPT----------- 544 E+ A+ +AAG E + E+ + ++ + P Sbjct: 210 RLEDMARWVLEAAGIREFELVTESSVVYGDTVDVMKGDLELASGAMGPHFLDEKWEIFDP 269 Query: 545 -AGWGMGIDRVAMFLTDSNNIK 565 G G G++R+ M + +++ Sbjct: 270 WVGLGFGLERLLMIREGTQHVQ 291 >11AS-A nrPDB Length = 330 Score = 46.8 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 49/352 (13%), Positives = 96/352 (27%), Gaps = 59/352 (16%) Query: 240 VRQKFIIRSKIITYIRSFLDEL-----GFLEIETPMMNIIPGGAVAKPFITYHNELDMNL 294 ++ +I + + I++++S G +E++ P+++ + G Sbjct: 1 MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGAEKAVQVKVK 60 Query: 295 YMRIA-----PELYH---KMLVVGGI---DRVYEIGRQFR-NEGI-DLTHNPEFTTCEFY 341 + A L + L + +Y + R +E H+ ++ Sbjct: 61 ALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWE 120 Query: 342 MAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPE----GQAYDVDFTPPFRRINMV 397 D + V + I + G Q + V R + Sbjct: 121 RVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFGLAPFLPDQIHFVHSQELLSRYPDL 180 Query: 398 EELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCI 457 + + + +F K+ D V P + E Sbjct: 181 DAKGRERAIAKDLGAVFLVGIGGKLSD--GHRHDVRAPDYDDWST-----PSELGHAGLN 233 Query: 458 NPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAK 517 + + L + FEL M ++ + QL Sbjct: 234 GDILVWN---------------PVLEDAFELSSMGI-------RVDADTLKHQL------ 265 Query: 518 AKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLL 569 A DE E L +P T G G+G R+ M L +I +V Sbjct: 266 --ALTGDEDRLELEWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQA 315 >4LNS-A nrPDB Length = 351 Score = 45.6 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 36/251 (14%), Positives = 78/251 (31%), Gaps = 28/251 (11%) Query: 337 TCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINM 396 ++ M D + +++V + I + + P + Sbjct: 119 QWDWEMVMKDDQRNLAFLKEVVCKVYAAIRKTELAVCEKYKQK------PILPETIQFVH 172 Query: 397 VEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTC 456 E L L NL E R+I + + ++ D ++ + T Sbjct: 173 AEHLL------LAYPNLTAKEREREIAREYGAVFLIGIGAVLSSGDRHDARAPDYDDWTS 226 Query: 457 INPTFICDHPQIMSPLAKWHRSKEGLTERFELFV------MKKEICNAYTELNDPMRQRQ 510 P+ P+ + ++ + E+ + +N + Q Sbjct: 227 PVEASQVVFPRTSKPIPTMNSLSSLKGLNGDILLYNPTLDDSLEVSSMGIRVNAEALRHQ 286 Query: 511 LFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLF 570 + + D+++ E L P T G G+G R+ MF+ +I EV Sbjct: 287 I--------SLTGDDSLLKSEWHQQLLNGEFPQTVGGGIGQSRMVMFMLRKKHIGEVQC- 337 Query: 571 PAMKPEDKKEN 581 ++ PE+ ++ Sbjct: 338 -SVWPEEIRKK 347 >3L4G-A nrPDB Length = 508 Score = 44.5 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 31/169 (18%), Positives = 61/169 (36%), Gaps = 17/169 (10%) Query: 314 RVYEIGRQFRNEGIDLTHNPEFTTCEFYMA--YADYHDLMEITEKMVSGMVKHITGSYKV 371 + + I R FRNE +D TH EF E +A LM + + + + G ++ Sbjct: 349 KYFSIDRVFRNETLDATHLAEFHQIEGVVADHGLTLGHLMGVLREFFTKL-----GITQL 403 Query: 372 TYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICV-AK 430 + P AY+ P + + L+K + + E + +++ V A Sbjct: 404 RFKP------AYNPYTEPSMEVFSYHQGLKKWVEVGNSGVFRPEMLLPMGLPENVSVIAW 457 Query: 431 AVECPPPRTTARLLD---KLVGEFLEVTCINPTFICDHPQIMSPLAKWH 476 + P ++ +LVG + + + + +C P Sbjct: 458 GLSLERPTMIKYGINNIRELVGHKVNLQMVYDSPLCRLDAEPRPPPTQE 506 >3TUP-A nrPDB Length = 415 Score = 42.1 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 47/292 (16%), Positives = 82/292 (28%), Gaps = 101/292 (34%) Query: 282 PFITYHNELDMNLYMRIAPEL------YHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEF 335 P + N Y+ L + L+ G+D +G +R + ID H P F Sbjct: 96 PADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRRDQIDSQHYPIF 155 Query: 336 TTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRIN 395 E ++ + ++ +G+ Sbjct: 156 HQLEAVRLFSKH--------ELFAGIKD-------------------------------- 175 Query: 396 MVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVT 455 G L ++ + K VE +T RL+ L G+ LE+ Sbjct: 176 ---------GESLQLFEQSSRSAHKQETHTMEAVKLVEFDLKQTLTRLMAHLFGDELEIR 226 Query: 456 CINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQ 515 ++ F HP FE+ + E Sbjct: 227 WVDCYFPFTHP------------------SFEMEINFH-------------------GEW 249 Query: 516 AKAKAAGDDEAMFIDENFCTALEYGLPPTAGW--GMGIDRVAMFLTDSNNIK 565 + G E ++ G GW G+G++R+AM L D +I+ Sbjct: 250 LEVLGCGVMEQQLVNSA-------GAQDRIGWAFGLGLERLAMILYDIPDIR 294 >5LR8-A nrPDB Length = 938 Score = 41.8 bits (96), Expect = 8e-04, Method: Composition-based stats. Identities = 26/182 (14%), Positives = 65/182 (35%), Gaps = 16/182 (8%) Query: 334 EFTTCEFYMAYADYH-DLMEIT-EKMVSGMVKHITGSYKVTYHPDGPEGQAYD-VDFTPP 390 E + + H +++E E++++ +V + + + D VD Sbjct: 387 EKWSLDIMQKLLPRHVEIIETIDEELMNNIVSKYGTADISLLKQKLKDMRILDNVDLPAS 446 Query: 391 FRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGE 450 ++ + + ++ L E+ E+ D+ ++ VE TT + + E Sbjct: 447 VAKLFIKPKEKRGK-------LLVESLESIAEADEKTESQEVENILSETTEKKAESDSEE 499 Query: 451 FLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQ 510 + +P + + P AK+ + L V+ N E++ + ++ Sbjct: 500 APDAEKEDPEY------ELDPFAKYDPQFPRVVRMANLCVVGGHSVNGVAEIHSEIVKQD 553 Query: 511 LF 512 +F Sbjct: 554 VF 555 >3M8U-A nrPDB Length = 522 Score = 37.9 bits (86), Expect = 0.014, Method: Composition-based stats. Identities = 11/60 (18%), Positives = 22/60 (36%), Gaps = 7/60 (11%) Query: 286 YHNELDMNLYMRIAPELYHKMLVVGGIDRVYE----IGRQFRNEGIDLTHNPEFTTCEFY 341 Y+NE+ Y +PE ++L G + +E + R + E ++ Sbjct: 319 YNNEITGYEY---SPEKAKQLLKEAGFENGFETDIWVQPVVRASNPNPRRMAELVQSDWE 375 >1NJ8-A nrPDB Length = 459 Score = 36.0 bits (81), Expect = 0.048, Method: Composition-based stats. Identities = 47/292 (16%), Positives = 86/292 (29%), Gaps = 44/292 (15%) Query: 244 FIIRSKIITYIRSFLDELGFLEIETPMMNI----------IPGGAVAKPFITYHN--ELD 291 F IR IR+ LDE G E PM+ I G ++T+ +LD Sbjct: 38 FKIRRYTFEIIRNLLDESGHDEALFPMLIPEDLLAKEAEHIKGFEDEVYWVTHGGKTQLD 97 Query: 292 MNLYMR---IAPELYHKMLVV---GGID-RVYEIGRQFRNEGIDLTHNPEFTTCEFYMAY 344 + L +R P Y L V + ++Y+I FR E M + Sbjct: 98 VKLALRPTSETPIYYMMKLWVKVHTDLPIKIYQIVNTFRYETKHTRPL---IRLREIMTF 154 Query: 345 ADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKAL 404 + H E+ + + K YK + G F Sbjct: 155 KEAHTAHSTKEEAENQV-KEAISIYKKFFDTLGIPYLISKRPEWDKFPGAEYTMA----F 209 Query: 405 GMKLPETNLFETEETRKILDDICVAKAVECPPP--------RTTARLLDKLVGEFL---- 452 P+ + + + + P +T + D+++ + Sbjct: 210 DTIFPDGRTMQIATVHNLGQNFSKTFEIIFETPTGDKDYAYQTCYGISDRVIASIIAIHG 269 Query: 453 -EVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELN 503 E I P + ++ PL + + + E++ E ++ Sbjct: 270 DEKGLILPPIVAPIQVVIVPLIFKGKEDIVMEKAKEIY----EKLKGKFRVH 317 >6HXI-A nrPDB Length = 421 Score = 35.6 bits (80), Expect = 0.065, Method: Composition-based stats. Identities = 18/82 (21%), Positives = 27/82 (32%), Gaps = 1/82 (1%) Query: 94 PYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGG-KLIFYDLRGEGV 152 +P F S + K + G L L GR+ A GG +I+ D + Sbjct: 235 AFPEPFGRTPSKEELFIKEIDSKTGASLKLTILNPEGRVWTMVAGGGASVIYADTICDLG 294 Query: 153 KLQVMANSRNYKSEEEFIHINN 174 MAN Y + + Sbjct: 295 HADEMANYGEYSGDPNTEETYH 316 >6HV9-B nrPDB Length = 689 Score = 35.2 bits (79), Expect = 0.082, Method: Composition-based stats. Identities = 19/148 (12%), Positives = 51/148 (34%), Gaps = 12/148 (8%) Query: 379 EGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPR 438 E + D + F+R + ++ + N+ + +D++ E Sbjct: 538 EIVIFRDDLSGRFKRHRLEFPFNESEDVYTENDNMMSKDTDIVPIDELVK----EPDQLP 593 Query: 439 TTARLLDKLVGEFLEVTCINPT--------FICDHPQIMSPLAKWHRSKEGLTERFELFV 490 + KLV L+ ++P + DH + P+ + + +F+L Sbjct: 594 QKVQETRKLVKTILDQGHLSPFLDSLRPISWDLDHTLTLCPIPSTMVLCDTTSAQFDLTY 653 Query: 491 MKKEICNAYTELNDPMRQRQLFEEQAKA 518 ++ N + +++ + + +K Sbjct: 654 NGCKVINPGSFIHNRRARYMEYVPSSKK 681 >1ADJ-A nrPDB Length = 421 Score = 34.1 bits (76), Expect = 0.17, Method: Composition-based stats. Identities = 51/339 (15%), Positives = 99/339 (29%), Gaps = 59/339 (17%) Query: 242 QKFIIRSKIITYIRSFLDELGFLEIETPMM---NIIPGGAVAKPFITYHNEL----DMNL 294 ++ + +I+ R L+ G LE+ TP+ + G A I Sbjct: 15 KELRMHQRIVATARKVLEAAGALELVTPIFEETQVFEKGVGAATDIVRKEMFTFQDRGGR 74 Query: 295 YMRIAPE---------LYHKMLVVGGIDRVYEIGRQFRNE-----GIDLTHNPEFTTCEF 340 + + PE L H M V R++ G FR E H + Sbjct: 75 SLTLRPEGTAAMVRAYLEHGMKVWPQPVRLWMAGPMFRAERPQKGRYRQFHQVNYEALGS 134 Query: 341 YMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHP-DGPEGQAYDVDFTPPFRRINMVEE 399 D ++ + E + ++ + P D AY + P R E Sbjct: 135 ENPILDAEAVVLLYECLKELGLRRLKVKLSSVGDPEDRARYNAYLREVLSPHR-----EA 189 Query: 400 LEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINP 459 L + +L E + + + + V R + +GE Sbjct: 190 LSEDSKERLEENPMRILDSKSERDQALLKELGV---------RPMLDFLGEEARAHLKE- 239 Query: 460 TFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAK 519 + H + +S + + L + +V A+ ++ + + + Sbjct: 240 --VERHLERLSVPYEL---EPALVRGLDYYVR-----TAFEVHHEEIGAQSALGGGGRYD 289 Query: 520 AAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFL 558 + P G+ G++RVA+ L Sbjct: 290 GLSELLGGPR------------VPGVGFAFGVERVALAL 316 >2Q1Z-A nrPDB Length = 184 Score = 33.7 bits (75), Expect = 0.27, Method: Composition-based stats. Identities = 19/123 (15%), Positives = 41/123 (33%), Gaps = 10/123 (8%) Query: 249 KIITYIRSFLDELGFLEIE---TPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYH- 304 ++ IR DE F E+ P + + + D+ + L+ Sbjct: 15 ALMRAIRDHRDEAAFAELFQHFAPKVKGFLMKSGSVASQAEECAQDVMATVWQKAHLFDP 74 Query: 305 KMLVVGGIDRVYEIGRQFRNEGIDLTHNPE----FTTCEFYMAYADYHDLMEITEKMVSG 360 V ++ I R R +G+ PE F + AD +++ + ++ Sbjct: 75 SRASVATW--IFTIARNRRIDGLRKDRQPEPEDLFWGPDSEPDQADVYEMQQENARLGRA 132 Query: 361 MVK 363 + + Sbjct: 133 IAR 135 >2DU4-A nrPDB Length = 534 Score = 32.9 bits (73), Expect = 0.43, Method: Composition-based stats. Identities = 13/46 (28%), Positives = 29/46 (63%), Gaps = 2/46 (4%) Query: 538 EYGLP-PTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENV 582 EY +P P G+G++R+AM L +++++++ +P + E K ++ Sbjct: 316 EYDIPYPVMNLGLGVERLAMILYGYDDVRKMV-YPQIHGEIKLSDL 360 >2ALY-A nrPDB Length = 266 Score = 32.1 bits (71), Expect = 0.76, Method: Composition-based stats. Identities = 11/34 (32%), Positives = 18/34 (52%), Gaps = 6/34 (17%) Query: 538 EYGLPPT----AGW--GMGIDRVAMFLTDSNNIK 565 GLPP G+ G+G++R+AM +I+ Sbjct: 216 RLGLPPAYRGVTGFAFGLGVERLAMLRYGIPDIR 249 >4GX0-A nrPDB Length = 565 Score = 31.4 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 32/172 (18%), Positives = 51/172 (29%), Gaps = 12/172 (6%) Query: 63 GVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLT 122 G PE+E + + +I A L D + Y G L Sbjct: 343 GEAPEDELIFIIGHGRIGCAAAAFLDRKPVPFILIDRQESPVCNDHVVVYGDATVGQTLR 402 Query: 123 DITLKVAGRIHAKRASGGKLIFYDL--RGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD 180 + A I IF L R ++++A + ++ ++ D Sbjct: 403 QAGIDRASGIIVTTNDDSTNIFLTLACRHLHSHIRIVARANGEENVDQLYAAGA-----D 457 Query: 181 IIGVQGNPGKTKKGELSIIPYEITLLSPCL----HMLPHLHFGLKDKETRYR 228 + + G G L + E LS + LP G ETR R Sbjct: 458 FVVSNASVGANILGNL-LEHKESAFLSEGMAVFRRPLPPAMAGKTIAETRLR 508 >4GVL-A nrPDB Length = 462 Score = 31.4 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 32/172 (18%), Positives = 51/172 (29%), Gaps = 12/172 (6%) Query: 63 GVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLT 122 G PE+E + + +I A L D + Y G L Sbjct: 240 GEAPEDELIFIIGHGRIGCAAAAFLDRKPVPFILIDRQESPVCNDHVVVYGDATVGQTLR 299 Query: 123 DITLKVAGRIHAKRASGGKLIFYDL--RGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD 180 + A I IF L R ++++A + ++ ++ D Sbjct: 300 QAGIDRASGIIVTTNDDSTNIFLTLACRHLHSHIRIVARANGEENVDQLYAAGA-----D 354 Query: 181 IIGVQGNPGKTKKGELSIIPYEITLLSPCL----HMLPHLHFGLKDKETRYR 228 + + G G L + E LS + LP G ETR R Sbjct: 355 FVVSNASVGANILGNL-LEHKESAFLSEGMAVFRRPLPPAMAGKTIAETRLR 405 >2O1T-A nrPDB Length = 450 Score = 31.0 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 43/326 (13%), Positives = 105/326 (32%), Gaps = 38/326 (11%) Query: 247 RSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKM 306 + K++ IR L +++I A K T+ E N+ K+ Sbjct: 138 QHKLLKVIRKKLVRK--------TLDMIKKIADEKYNDTFWKEFGTNI----------KL 179 Query: 307 LVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHIT 366 V+ + + R + H + T+ + Y+ M+ + + M Sbjct: 180 GVIEDHSNRTRLAKLLRFQSSH--HPSDITSLDQYVER------MKEKQDKIYFMAGSSR 231 Query: 367 GSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDI 426 + + + + Y+V + ++ L + G + E + + Sbjct: 232 KEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAK-EGVKFDESEKTK 290 Query: 427 CVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERF 486 +A+E + DK + + +E ++ +++ W + E + + Sbjct: 291 ESREAIEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKA- 349 Query: 487 ELFVMKKEIC---NAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALE----- 538 + + K+I A + + R + + D++ + + E Sbjct: 350 QAYQTGKDISTNYYASQKKTFEINPRHPLIKDMLRRVKEDEDDKTVSDLAVVLFETATLR 409 Query: 539 --YGLPPTAGWGMGIDRVAMFLTDSN 562 Y LP T +G I+R+ + + Sbjct: 410 SGYLLPDTKAYGDRIERMLRLSLNID 435 >1PYS-A nrPDB Length = 350 Score = 31.0 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 10/34 (29%), Positives = 17/34 (50%), Gaps = 6/34 (17%) Query: 538 EYGLPPTA------GWGMGIDRVAMFLTDSNNIK 565 GLPP +G+G++R+AM +I+ Sbjct: 300 RLGLPPAYRGVTGFAFGLGVERLAMLRYGIPDIR 333 >2FD5-A nrPDB Length = 180 Score = 30.6 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 17/78 (21%), Positives = 30/78 (38%), Gaps = 5/78 (6%) Query: 239 FVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRI 298 +K R++I+ L E G +E P + + G A Y + + M Sbjct: 1 MSDKKTQTRARILGAATQALLERGAVE---PSVGEVMGAAGLTVGGFYAHFQSKDALMLE 57 Query: 299 APE--LYHKMLVVGGIDR 314 A E L + ++G +D Sbjct: 58 AFEQLLGKRRELLGELDP 75 >4HKA-A nrPDB Length = 366 Score = 30.6 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 33/216 (15%), Positives = 75/216 (34%), Gaps = 44/216 (20%) Query: 220 LKDKETRYRQRYLDLILNDFVRQKFIIRSK---IITYIRSFLDELGFLEIETPMMNIIPG 276 L ++ RY Q+Y D+ ++ R K ++ ++ +L+ TP Sbjct: 131 LTEQRVRYNQKYSDVFSDEEARNSIRNSEKDPSLLELVQRWLER-------TP------- 176 Query: 277 GAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFT 336 G F + + + + + + V ++ E + +R I+ Sbjct: 177 GLEESGFNFWAKFQE-------SVDRFLEAQVQSAMEEPVEKAKNYRLMDIEKRR----- 224 Query: 337 TCEFYMAYAD---YHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQ--------AYDV 385 E Y + D + L+ ++ S + + G+ +T++ D P D+ Sbjct: 225 --EVYRSIFDPAVHDALVRRGDRRFSH--RALQGAIMITFYRDEPRFSQPHQLLTLLMDI 280 Query: 386 DFTPPFRRINMVEELEKALGMKLPETNLFETEETRK 421 D R N V +++ +G + T + + Sbjct: 281 DSLITKWRYNHVIMVQRMIGSQQLGTGGSSGYQYLR 316 >5ICJ-A nrPDB Length = 221 Score = 30.2 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 15/70 (21%), Positives = 23/70 (32%), Gaps = 3/70 (4%) Query: 228 RQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYH 287 R ++++ + R +IT R G+ E+ TP I A YH Sbjct: 17 RGSHMEIKRRTQEERSAATREALITGARKLWGLRGYAEVGTP---EIATEAGVTRGAMYH 73 Query: 288 NELDMNLYMR 297 D R Sbjct: 74 QFADKAALFR 83 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.304 0.119 0.292 Lambda K H 0.267 0.0369 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,852,027 Number of Sequences: 36641 Number of extensions: 788969 Number of successful extensions: 2815 Number of sequences better than 10.0: 62 Number of HSP's better than 10.0 without gapping: 83 Number of HSP's successfully gapped in prelim test: 35 Number of HSP's that attempted gapping in prelim test: 2449 Number of HSP's gapped (non-prelim): 162 length of query: 597 length of database: 10,336,785 effective HSP length: 103 effective length of query: 494 effective length of database: 6,562,762 effective search space: 3242004428 effective search space used: 3242004428 T: 11 A: 40 X1: 16 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.0 bits) S2: 62 (28.6 bits)