BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q14376 (348 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1I3M-A nrPDB 723 0.0 3ENK-A nrPDB 408 e-114 1UDA-A nrPDB 375 e-104 1Z45-A nrPDB 370 e-103 4LIS-A nrPDB 360 e-100 4WOK-A nrPDB 240 8e-64 2C20-A nrPDB 225 2e-59 1GY8-A nrPDB 207 4e-54 2PZM-A nrPDB 84 8e-17 6BI4-A nrPDB 79 3e-15 1KEU-A nrPDB 75 3e-14 6BWL-A nrPDB 75 4e-14 1ORR-A nrPDB 74 1e-13 2Q1T-A nrPDB 73 1e-13 3RUE-A nrPDB 70 2e-12 1BXK-A nrPDB 68 5e-12 3SXP-A nrPDB 64 8e-11 1R66-A nrPDB 64 1e-10 1OC2-A nrPDB 64 1e-10 2HUN-A nrPDB 62 4e-10 2Q1W-A nrPDB 59 4e-09 5UZH-A nrPDB 59 4e-09 2Z95-A nrPDB 51 6e-07 1WVG-A nrPDB 50 1e-06 1RKX-A nrPDB 49 3e-06 4EJ0-A nrPDB 49 3e-06 2PK3-A nrPDB 48 6e-06 1RPN-A nrPDB 47 9e-06 1DB3-A nrPDB 46 3e-05 3M2P-A nrPDB 45 6e-05 6GPK-A nrPDB 44 1e-04 4BKP-A nrPDB 42 3e-04 1GFS-A nrPDB 42 3e-04 2NNL-D nrPDB 42 3e-04 5YWN-A nrPDB 42 4e-04 3WMX-A nrPDB 40 0.002 3SLK-A nrPDB 39 0.003 1EQ2-A nrPDB 37 0.010 3RFT-A nrPDB 37 0.013 4R1U-A nrPDB 37 0.018 2X86-A nrPDB 36 0.021 5U9C-A nrPDB 36 0.022 5B6K-A nrPDB 35 0.053 4KTT-E nrPDB 33 0.14 1ZZE-A nrPDB 33 0.14 5IZ4-A nrPDB 32 0.29 4AVY-A nrPDB 32 0.44 2GPY-A nrPDB 32 0.48 4PVC-A nrPDB 32 0.53 2P4H-X nrPDB 31 0.66 4R1T-A nrPDB 31 1.0 4J2O-A nrPDB 30 1.6 3PXX-A nrPDB 30 1.6 2QYS-A nrPDB 30 1.7 1QT1-A nrPDB 30 2.3 4WO8-A nrPDB 29 2.7 4F9J-A nrPDB 29 3.1 3VUS-A nrPDB 29 3.3 1HE4-A nrPDB 29 3.4 4KMS-A nrPDB 29 3.7 2B3T-A nrPDB 28 4.4 5ILO-A nrPDB 28 4.7 6AQY-A nrPDB 28 4.8 2X9N-A nrPDB 28 7.3 6GCS-E nrPDB 28 7.4 4WPG-A nrPDB 28 8.0 >1I3M-A nrPDB Length = 348 Score = 723 bits (1867), Expect = 0.0, Method: Compositional matrix adjust. Identities = 346/348 (99%), Positives = 347/348 (99%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV Sbjct: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 Query: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKA+GESVQKPLDYYRVNLTGTIQLLEIMK Sbjct: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAMGESVQKPLDYYRVNLTGTIQLLEIMK 120 Query: 121 AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA 180 AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWN Sbjct: 121 AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNV 180 Query: 181 VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD 240 VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD Sbjct: 181 VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD 240 Query: 241 YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR 300 YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR Sbjct: 241 YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR 300 Query: 301 EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA 348 EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA Sbjct: 301 EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA 348 >3ENK-A nrPDB Length = 341 Score = 408 bits (1049), Expect = e-114, Method: Compositional matrix adjust. Identities = 197/340 (57%), Positives = 246/340 (72%), Gaps = 7/340 (2%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 +LVTGGAGYIGSHT +ELL GY V+ DN N+ R E++ R++++TG++ F E Sbjct: 8 ILVTGGAGYIGSHTAVELLAHGYDVVIADNLVNSKR------EAIARIEKITGKTPAFHE 61 Query: 65 MDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGV 124 D+ D+ AL R+F + A IHFA LKAVGESV KP++YYR NL + LL +M+ V Sbjct: 62 TDVSDERALARIFDAHPITAAIHFAALKAVGESVAKPIEYYRNNLDSLLSLLRVMRERAV 121 Query: 125 KNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLR 184 K +VFSSSATVYG P+ P+DE P TNPYG++K E+++RD+ AD +W LR Sbjct: 122 KRIVFSSSATVYGVPERSPIDETFPLS-ATNPYGQTKLMAEQILRDVEAADPSWRVATLR 180 Query: 185 YFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHV 244 YFNP GAH SG IGEDP GIPNNLMPYV+QVA+G+ E L VFG+DY T DGTGVRDYIHV Sbjct: 181 YFNPVGAHESGLIGEDPAGIPNNLMPYVAQVAVGKLEKLRVFGSDYPTPDGTGVRDYIHV 240 Query: 245 VDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDV 304 VDLA+GHIAAL L+ + NLGTG GYSVL++V+A EKASG+ +PY++VARR GDV Sbjct: 241 VDLARGHIAALDALERRDASLTVNLGTGRGYSVLEVVRAFEKASGRAVPYELVARRPGDV 300 Query: 305 AACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGF 344 A CYANP+ A E +GW A L+RMC D WRWQ+ NP GF Sbjct: 301 AECYANPAAAAETIGWKAERDLERMCADHWRWQENNPRGF 340 >1UDA-A nrPDB Length = 338 Score = 375 bits (964), Expect = e-104, Method: Compositional matrix adjust. Identities = 179/341 (52%), Positives = 235/341 (68%), Gaps = 6/341 (1%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 +VLVTGG+GYIGSHT ++LL+ G+ +++DN N+ R L ++ L G+ F Sbjct: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKR------SVLPVIERLGGKHPTFV 55 Query: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHG 123 E DI ++ + + ++ VIHFAGLKAVGESVQKPL+YY N+ GT++L+ M+A Sbjct: 56 EGDIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAAN 115 Query: 124 VKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLL 183 VKN +FSSSATVYG+ +P E+ PTG +PYGKSK +E+++ DL +A W+ LL Sbjct: 116 VKNFIFSSSATVYGDNPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALL 175 Query: 184 RYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIH 243 RYFNP GAH SG +GEDPQGIPNNLMPY++QVA+GRR++L +FGNDY TEDGTGVRDYIH Sbjct: 176 RYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIH 235 Query: 244 VVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGD 303 V+DLA GH+ A+ KL + G IYNLG G G SVL +V A KA GK + Y RREGD Sbjct: 236 VMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGD 295 Query: 304 VAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGF 344 + A +A+ S A EL W LD M +D W WQ ++P G+ Sbjct: 296 LPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGY 336 >1Z45-A nrPDB Length = 699 Score = 370 bits (951), Expect = e-103, Method: Compositional matrix adjust. Identities = 189/349 (54%), Positives = 242/349 (69%), Gaps = 16/349 (4%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 VLVTGGAGYIGSHTV+EL+E GY VV DN N S +S+ R++ LT + F E Sbjct: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSN------STYDSVARLEVLTKHHIPFYE 67 Query: 65 MDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGV 124 +D+ D+ L+++FK+Y +VIHFAGLKAVGES Q PL YY N+ GT+ LLE+M+ + V Sbjct: 68 VDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNV 127 Query: 125 KNLVFSSSATVYGN----PQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADK-TWN 179 VFSSSATVYG+ P +P+ E P G TNPYG +K+ IE ++ DL +DK +W Sbjct: 128 SKFVFSSSATVYGDATRFPNMIPIPEECPLGP-TNPYGHTKYAIENILNDLYNSDKKSWK 186 Query: 180 AVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVR 239 +LRYFNP GAH SG IGEDP GIPNNL+PY++QVA+GRRE L +FG+DYD+ DGT +R Sbjct: 187 FAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIR 246 Query: 240 DYIHVVDLAKGHIAALRKLK---EQCG-CRIYNLGTGTGYSVLQMVQAMEKASGKKIPYK 295 DYIHVVDLAKGHIAAL+ L+ E G CR +NLG+G G +V ++ A KASG +PYK Sbjct: 247 DYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYK 306 Query: 296 VVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGF 344 V RR GDV A P A+ EL W L ++ C+DLW+W +NP G+ Sbjct: 307 VTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGY 355 >4LIS-A nrPDB Length = 371 Score = 360 bits (925), Expect = e-100, Method: Compositional matrix adjust. Identities = 185/362 (51%), Positives = 237/362 (65%), Gaps = 26/362 (7%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 VLVTGG GYIGS T L LLEAGY VV DN +N S E+L R++ ++G+ EF + Sbjct: 6 VLVTGGTGYIGSFTTLALLEAGYKVVVADNLYN------SSAEALNRIELISGKKAEFAQ 59 Query: 65 MDILDQGALQRLFKKYSFM-AVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHG 123 +D+ D+ A ++F+ + + +VIHFA LKAVGES +KPLDYY VN+ GTI LL M H Sbjct: 60 LDVTDEAAFDKVFEAHPDIDSVIHFAALKAVGESGEKPLDYYHVNVYGTICLLRSMVRHN 119 Query: 124 VKNLVFSSSATVYGN----PQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKT-- 177 V N+VFSSSATVYG+ P +P+ E P G TNPYG +KF IE I D+ A + Sbjct: 120 VTNIVFSSSATVYGDATRFPDMIPIPEHCPLG-PTNPYGNTKFAIELAITDVINAQRNNA 178 Query: 178 -----------WNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVF 226 WN LLRYFNP GAH SG +GEDPQG+P NL+P ++QVA G+RE L VF Sbjct: 179 KKAGNETEAAKWNGALLRYFNPAGAHPSGIMGEDPQGVPYNLLPLLAQVATGKREKLLVF 238 Query: 227 GNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLK-EQCGCRIYNLGTGTGYSVLQMVQAME 285 G+DY + DGT +RDYIH++DLA GH+ AL L+ G R +NLGTG G +V +M++A Sbjct: 239 GDDYASHDGTAIRDYIHILDLADGHLKALNYLRANNPGVRAWNLGTGRGSTVYEMIRAFS 298 Query: 286 KASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFG 345 KA G+ +PY+V RR GDV +NP+ A ELGW A L++ CEDLW W K NP G+ Sbjct: 299 KAVGRDLPYEVAPRRAGDVLNLTSNPTRANTELGWKAQRTLEQACEDLWLWTKNNPQGYR 358 Query: 346 TQ 347 Q Sbjct: 359 QQ 360 >4WOK-A nrPDB Length = 336 Score = 240 bits (612), Expect = 8e-64, Method: Compositional matrix adjust. Identities = 139/321 (43%), Positives = 183/321 (57%), Gaps = 21/321 (6%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 A VLV GGAG+IGSHT L GY PVV DN + R + Sbjct: 11 ANNVLVVGGAGFIGSHTAKLLAGQGYAPVVYDNLSTG--------------HQSAVRWGD 56 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 F E DILDQ L +KY+ +AVIHFA VGESV+ P YYR N+ GT LL+ + Sbjct: 57 FVEGDILDQARLVETMEKYAPVAVIHFAASAYVGESVEDPAKYYRNNVGGTQSLLDACRL 116 Query: 122 HGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAV 181 +N++FSSS YG P LP+ E NPYG++K E M+ D A V Sbjct: 117 TRTQNVIFSSSCATYGVPSRLPIGEGEAQN-PINPYGRTKLIAEHMLADYAVA-YGLRYV 174 Query: 182 LLRYFNPTGAHASGCIGE--DPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVR 239 LRYFN +GA G +GE DP+ +L+P A GR + L V+G+DY+T DGT +R Sbjct: 175 ALRYFNASGADIDGELGEKHDPE---THLIPRAMMAAAGRLDVLEVYGDDYETPDGTCIR 231 Query: 240 DYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVAR 299 DYIHV DLA+ H+ A+ LKE G NLGTG G S+ ++VQ++ + +G+ +P + AR Sbjct: 232 DYIHVTDLARAHVLAVEHLKEAGGNLAVNLGTGRGTSIREIVQSIGRLTGRSVPVAMRAR 291 Query: 300 REGDVAACYANPSLAQEELGW 320 R GD A YA+P+LA E+LG+ Sbjct: 292 RAGDPPALYADPALAAEKLGF 312 >2C20-A nrPDB Length = 330 Score = 225 bits (574), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 128/341 (37%), Positives = 188/341 (55%), Gaps = 17/341 (4%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 +L+ GGAGYIGSH V +L++ G VV+DN ++ +F Sbjct: 4 ILICGGAGYIGSHAVKKLVDEGLSVVVVDNLQTGH-------------EDAITEGAKFYN 50 Query: 65 MDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGV 124 D+ D+ L+ +F + + AV+HFA VG S++KPL YY N+ G + LLE+M V Sbjct: 51 GDLRDKAFLRDVFTQENIEAVMHFAADSLVGVSMEKPLQYYNNNVYGALCLLEVMDEFKV 110 Query: 125 KNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLR 184 +FSS+A YG + E T TN YG++K IE+M+ QA + R Sbjct: 111 DKFIFSSTAATYGEVDVDLITEETMTN-PTNTYGETKLAIEKMLHWYSQA-SNLRYKIFR 168 Query: 185 YFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHV 244 YFN GA +G IGED + +L+P V QVA+G+RE + +FG+DY+T DGT +RDYIHV Sbjct: 169 YFNVAGATPNGIIGEDHRP-ETHLIPLVLQVALGQREKIMMFGDDYNTPDGTCIRDYIHV 227 Query: 245 VDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDV 304 DL H L+ L+ YNLG G G+SV ++V A+ + + +IP +V RR GD Sbjct: 228 EDLVAAHFLGLKDLQNGGESDFYNLGNGNGFSVKEIVDAVREVTNHEIPAEVAPRRAGDP 287 Query: 305 AACYANPSLAQEELGWTAA-LGLDRMCEDLWRWQKQNPSGF 344 A A+ A+E+LGW + + + E W W ++ P+G+ Sbjct: 288 ARLVASSQKAKEKLGWDPRYVNVKTIIEHAWNWHQKQPNGY 328 >1GY8-A nrPDB Length = 397 Score = 207 bits (528), Expect = 4e-54, Method: Compositional matrix adjust. Identities = 142/385 (36%), Positives = 197/385 (51%), Gaps = 44/385 (11%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPES----LRRVQELTG-- 57 +VLV GGAGYIGSH V LL VVI + G E+ R++Q+ G Sbjct: 4 RVLVCGGAGYIGSHFVRALLRDTNHSVVIVDSLVGTHGKSDHVETRENVARKLQQSDGPK 63 Query: 58 -----RSVEFEEMDILDQGALQRLFKKYSFM-AVIHFAGLKAVGESVQKPLDYYRVNLTG 111 R E D+ ++ L +F ++ + AV+H AVGESV+ PL YY N+ G Sbjct: 64 PPWADRYAALEVGDVRNEDFLNGVFTRHGPIDAVVHMCAFLAVGESVRDPLKYYDNNVVG 123 Query: 112 TIQLLEIMKAHGVKNLVFSSSATVYGNPQY-------LPLDEAHPTGGCTNPYGKSKFFI 164 ++LL+ M H ++FSSSA ++GNP P+D + +PYG+SK Sbjct: 124 ILRLLQAMLLHKCDKIIFSSSAAIFGNPTMGSVSTNAEPID-INAKKSPESPYGESKLIA 182 Query: 165 EEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQG----IPNNLMPYVSQVAIGRR 220 E MIRD C + LRYFN GAH G IGE QG IP L +S +A +R Sbjct: 183 ERMIRD-CAEAYGIKGICLRYFNACGAHEDGDIGEHYQGSTHLIPIILGRVMSDIAPDQR 241 Query: 221 ----------EALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCR----- 265 + + +FG DY T DGT VRDY+HV DLA HI AL + E+ G Sbjct: 242 LTIHEDASTDKRMPIFGTDYPTPDGTCVRDYVHVCDLASAHILALDYV-EKLGPNDKSKY 300 Query: 266 --IYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAA 323 ++NLGT GYSV ++++ K +G IP + RREGD A A A+E LGW Sbjct: 301 FSVFNLGTSRGYSVREVIEVARKTTGHPIPVRECGRREGDPAYLVAASDKAREVLGWKPK 360 Query: 324 LG-LDRMCEDLWRWQKQNPSGFGTQ 347 L+ + E W++Q+ +P+G+ +Q Sbjct: 361 YDTLEAIMETSWKFQRTHPNGYASQ 385 >2PZM-A nrPDB Length = 330 Score = 84.3 bits (207), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 93/340 (27%), Positives = 144/340 (42%), Gaps = 56/340 (16%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 ++L+TGGAG +GS+ + L G+ +VIDNF R E L V L+ Sbjct: 22 RILITGGAGCLGSNLIEHWLPQGHEILVIDNFATGKR------EVLPPVAGLS-----VI 70 Query: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYR---VNLTGTIQLLEIMK 120 E + D G L+R F + V+H A + + P D+ N+ G+I + + Sbjct: 71 EGSVTDAGLLERAFDSFKPTHVVHSAA------AYKDPDDWAEDAATNVQGSINVAKAAS 124 Query: 121 AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEE--MIRDLCQADKTW 178 GVK L+ +A YG P +P+ PT T+ YG SK E M+ D+ Sbjct: 125 KAGVKRLLNFQTALCYGRPATVPIPIDSPTAPFTS-YGISKTAGEAFLMMSDV------- 176 Query: 179 NAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGV 238 V LR N TG + IG P + ++ G++ F +D V Sbjct: 177 PVVSLRLANVTGPRLA--IGPIPT--------FYKRLKAGQK----CFCSDT-------V 215 Query: 239 RDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKI--PYKV 296 RD++ + D IA L L+E ++N+ TG G+S+ ++ + G + P V Sbjct: 216 RDFLDMSDFLA--IADL-SLQEGRPTGVFNVSTGEGHSIKEVFDVVLDYVGATLAEPVPV 272 Query: 297 VARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRW 336 VA DV + +PS + E GW A + W Sbjct: 273 VAPGADDVPSVVLDPSKTETEFGWKAKVDFKDTITGQLAW 312 >6BI4-A nrPDB Length = 346 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 90/345 (26%), Positives = 153/345 (44%), Gaps = 37/345 (10%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 A +LVTGGAG+IGS+ V +L++ Y I NF +A G+L +++ +Q+ + Sbjct: 24 AMNILVTGGAGFIGSNFVHYMLQS-YETYKIINF-DALTYSGNL-NNVKSIQD--HPNYY 78 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 F + +I + L+ + K+ +++FA V S++ P+ +Y N+ GT+ LLE++K Sbjct: 79 FVKGEIQNGELLEHVIKERDVQVIVNFAAESHVDRSIENPIPFYDTNVIGTVTLLELVKK 138 Query: 122 HGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAV 181 + LV S+ VYG+ +PY SK AD A Sbjct: 139 YPHIKLVQVSTDEVYGSLGKTGRFTEETPLAPNSPYSSSK----------ASADMIALAY 188 Query: 182 LLRYFNPT-GAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD 240 Y P S G P P L+P + A+ ++ L ++G DG VRD Sbjct: 189 YKTYQLPVIVTRCSNNYG--PYQYPEKLIPLMVTNALEGKK-LPLYG------DGLNVRD 239 Query: 241 YIHVVDLAKGHIAALRKL--KEQCGCRIYNLG---TGTGYSVLQMVQAMEKASGKKIPYK 295 ++HV D H +A+ + K + G +YN+G T V++ + + + K I Y Sbjct: 240 WLHVTD----HCSAIDVVLHKGRVG-EVYNIGGNNEKTNVEVVEQIITLLGKTKKDIEY- 293 Query: 296 VVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQN 340 V R G N + E W ++ ++ +W ++N Sbjct: 294 -VTDRLGHDRRYAINAEKMKNEFDWEPKYTFEQGLQETVQWYEKN 337 >1KEU-A nrPDB Length = 361 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 95/345 (27%), Positives = 139/345 (40%), Gaps = 57/345 (16%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVV-IDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 K+L+TGGAG+IGS V +++ VV ID A G+L ESL + E F Sbjct: 2 KILITGGAGFIGSAVVRHIIKNTQDTVVNIDKLTYA----GNL-ESLSDISE--SNRYNF 54 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 E DI D + R+F++Y AV+H A V S+ P + N+ GT LLE+ + + Sbjct: 55 EHADICDSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYALLEVARKY 114 Query: 123 GV-------KNLVFS--SSATVYG---------NPQYLPLDEAHPTGGCTNPYGKSKFFI 164 N F S+ VYG N LPL ++PY SK Sbjct: 115 WSALGEDKKNNFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKASS 174 Query: 165 EEMIRDLCQADKTWNAVLLRYFNPT-GAHASGCIGEDPQGIPNNLMPYVSQVAIGRREAL 223 + ++R W Y PT + S G P P L+P V A+ + L Sbjct: 175 DHLVR-------AWRRT---YGLPTIVTNCSNNYG--PYHFPEKLIPLVILNALEGK-PL 221 Query: 224 NVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMV-- 281 ++G G +RD+++V D A+ A + E YN+G L +V Sbjct: 222 PIYGK------GDQIRDWLYVEDHAR---ALHMVVTEGKAGETYNIGGHNEKKNLDVVFT 272 Query: 282 ------QAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGW 320 + + KA+ + VA R G + ELGW Sbjct: 273 ICDLLDEIVPKATSYREQITYVADRPGHDRRYAIDAGKISRELGW 317 >6BWL-A nrPDB Length = 328 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 92/340 (27%), Positives = 137/340 (40%), Gaps = 36/340 (10%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGG-GSLPESLRRVQELTGRSVEF 62 K+LVTGGAG+IG V LL+ + ++DN N+ L Q + G Sbjct: 2 KILVTGGAGFIGRWVVKRLLQDKHEVWILDNLANSTTANITEFAHDLNLKQCIQG----- 56 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 DI D+ + +LF+ SF H A V +S+ + + GT LLE + Sbjct: 57 ---DIKDKKLVAQLFENNSFDLCYHLAASINVQDSIDDARATFENDTIGTFNLLEQCLNY 113 Query: 123 GVKNLVFSSSATVYGNPQYLP-LDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAV 181 VK +VF S+ VY + + E P + PY SK E M+ A K V Sbjct: 114 DVK-MVFMSTCMVYDKATNIQGISELDPIKPAS-PYAGSKIAAENMVLSYYYAYKL-PVV 170 Query: 182 LLRYFNPTGA-HASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD 240 ++R FN G +G G NN + V LN++G DG RD Sbjct: 171 VIRPFNTYGPFQKTGGEGGVVAIFINNKLDNV---------PLNIYG------DGKQTRD 215 Query: 241 YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVA-- 298 ++V D A +AA K I N GTG S+ ++ + + SG K+ + V Sbjct: 216 LLYVEDCADFVVAAGYSAK--ANGHIINAGTGQDISINKLAELI---SGNKVSIQHVTHI 270 Query: 299 RREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQK 338 + ++ N A+ L W + L+ W K Sbjct: 271 HPQSEIQKLLCNYEKAKTILNWEPKVSLEDGVIKTEEWIK 310 >1ORR-A nrPDB Length = 347 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 71/283 (25%), Positives = 121/283 (42%), Gaps = 34/283 (12%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 K+L+TGG G++GS+ L G +V DN R G + ++L + L + EF Sbjct: 3 KLLITGGCGFLGSNLASFALSQGIDLIVFDNLS---RKGAT--DNLHWLSSLG--NFEFV 55 Query: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHG 123 DI ++ + RL KY + H AG A+ S+ P + +N+ GT+ LLE ++ + Sbjct: 56 HGDIRNKNDVTRLITKYMPDSCFHLAGQVAMTTSIDNPCMDFEINVGGTLNLLEAVRQYN 115 Query: 124 VK-NLVFSSSATVYGNPQYLPLDEAHPTGGCTN---------------PYGKSKFFIEEM 167 N+++SS+ VYG+ + +E C + PYG SK ++ Sbjct: 116 SNCNIIYSSTNKVYGDLEQYKYNETETRYTCVDKPNGYDESTQLDFHSPYGCSKGAADQY 175 Query: 168 IRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFG 227 + D + N V+ R+ + G QG ++ G + + G Sbjct: 176 MLDYARI-FGLNTVVFRHSSMYGGRQ---FATYDQGWVGWFCQKAVEIKNGINKPFTISG 231 Query: 228 NDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLG 270 N G VRD +H D+ + AL + + G +N+G Sbjct: 232 N------GKQVRDVLHAEDMISLYFTALANVSKIRG-NAFNIG 267 >2Q1T-A nrPDB Length = 377 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 85/350 (24%), Positives = 138/350 (39%), Gaps = 41/350 (11%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPV-VIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 V+V GGAG++GS+ V LLE G V V+DN +A ++ +V F Sbjct: 35 VMVVGGAGFVGSNLVKRLLELGVNQVHVVDNLLSA-----------EKINVPDHPAVRFS 83 Query: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHG 123 E I D L L +Y + V H A S+ PL + N T++L E +K Sbjct: 84 ETSITDDALLASLQDEYDY--VFHLATYHGNQSSIHDPLADHENNTLTTLKLYERLKHFK 141 Query: 124 -VKNLVFSSSATVYGNPQYLPLDEAHPT--------GGCTNPYGKSKFFIE--EMIRDLC 172 +K +V+S++ + D+A T +PY SK F E + Sbjct: 142 RLKKVVYSAAGCSIAEKTF---DDAKATEETDIVSLHNNDSPYSMSKIFGEFYSVYYHKQ 198 Query: 173 QADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMP-YVSQVAIGRREALNVFGNDYD 231 T A + P +G P + N+ P ++ + G L Sbjct: 199 HQLPTVRARFQNVYGPGEILGAGRWRGTPATVWRNVTPTFIYKALKGMPLPLE------- 251 Query: 232 TEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKK 291 G RD+I V D+A G IA + +YN+ +G S+ + + + +G Sbjct: 252 -NGGVATRDFIFVEDVANGLIAC---AADGTPGGVYNIASGKETSIADLATKINEITGNN 307 Query: 292 IPYKVVARREGDVAAC-YANPSLAQEELGWTAALGLDRMCEDLWRWQKQN 340 + +R D + + +P A+ ELG++A + +D W K N Sbjct: 308 TELDRLPKRPWDNSGKRFGSPEKARRELGFSADVSIDDGLRKTIEWTKAN 357 >3RUE-A nrPDB Length = 351 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 80/326 (24%), Positives = 147/326 (45%), Gaps = 37/326 (11%) Query: 6 LVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEM 65 L+TG AG+IGS+ + +LL+ + + +DNF + ++L ++ + F E Sbjct: 29 LITGVAGFIGSNLLEKLLKLNQVVIGLDNFSTGHQYNLDEVKTLVSTEQWS--RFCFIEG 86 Query: 66 DILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVK 125 DI D +++ K V+H A L +V S+ P+ N+TG + +L K V+ Sbjct: 87 DIRDLTTCEQVMKGVDH--VLHQAALGSVPRSIVDPITTNATNITGFLNILHAAKNAQVQ 144 Query: 126 NLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRY 185 + +++S++ YG+ LP E + G +PY +K ++ E+ + + + LRY Sbjct: 145 SFTYAASSSTYGDHPALPKVEEN-IGNPLSPYAVTK-YVNEIYAQVYARTYGFKTIGLRY 202 Query: 186 FNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGND-YDTEDGTGVRDYIHV 244 FN G +DP G ++P + A + G+D Y DG RD+ ++ Sbjct: 203 FNVFGRR------QDPNGAYAAVIP--------KWTAAMLKGDDVYINGDGETSRDFCYI 248 Query: 245 VDLAKGHIAALRKLKEQCGCRIYNLGTGTG----------YSVLQMVQAMEKASGKKIPY 294 ++ + +I + K+ IYN+ G Y L ++ ++K S K + Sbjct: 249 DNVIQMNILSALA-KDSAKDNIYNVAVGDRTTLNELSGYIYDELNLIHHIDKLSIKYREF 307 Query: 295 KVVARREGDVAACYANPSLAQEELGW 320 R GDV A+ + A + L + Sbjct: 308 -----RSGDVRHSQADVTKAIDLLKY 328 >1BXK-A nrPDB Length = 355 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 85/296 (28%), Positives = 130/296 (43%), Gaps = 47/296 (15%) Query: 4 KVLVTGGAGYIGSHTVLELL-EAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 K+L+TGGAG+IGS V ++ E VV+D A G+L SL V + F Sbjct: 3 KILITGGAGFIGSALVRYIINETSDAVVVVDKLTYA----GNL-MSLAPVAQ--SERFAF 55 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 E++DI D+ L R+F ++ V+H A V S+ P + N+ GT LLE +A+ Sbjct: 56 EKVDICDRAELARVFTEHQPDCVMHLAAESHVDRSIDGPAAFIETNIVGTYTLLEAARAY 115 Query: 123 GV-----KNLVFS----SSATVYGNPQYLP--LDEAHPTGGCTNPYGKSKFFIEEMIRDL 171 K F S+ VYG+ E P ++PY SK + ++R Sbjct: 116 WNALTEDKKSAFRFHHISTDEVYGDLHSTDDFFTETTPYAP-SSPYSASKASSDHLVR-- 172 Query: 172 CQADKTWNAVLLRYFNPT-GAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDY 230 A L Y PT + S G P P L+P + A+ + +L V+GN Sbjct: 173 --------AWLRTYGLPTLITNCSNNYG--PYHFPEKLIPLMILNALAGK-SLPVYGN-- 219 Query: 231 DTEDGTGVRDYIHVVDLAKGH--IAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAM 284 G +RD+++V D A+ +A K+ E YN+G L +V+ + Sbjct: 220 ----GQQIRDWLYVEDHARALYCVATTGKVGE-----TYNIGGHNERKNLDVVETI 266 >3SXP-A nrPDB Length = 362 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 78/298 (26%), Positives = 133/298 (44%), Gaps = 35/298 (11%) Query: 3 EKVLVTGGAGYIGSHTVLELLE--AGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 + +L+TGGAG++GS+ E VV+D F + + P SL + L G Sbjct: 11 QTILITGGAGFVGSNLAFHFQENHPKAKVVVLDKFRSNTLFSNNRPSSLGHFKNLIGFKG 70 Query: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 E DI + L+RL +K F + H A + Q+ + + N + LLEI + Sbjct: 71 EVIAADINNPLDLRRL-EKLHFDYLFHQAAVSDTTMLNQELV--MKTNYQAFLNLLEIAR 127 Query: 121 AHGVKNLVFSSSATVYGN---PQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKT 177 + K ++++SSA VYGN P + +E+ N YG SK ++E + L ++ Sbjct: 128 SKKAK-VIYASSAGVYGNTKAPNVVGKNES-----PENVYGFSKLCMDEFV--LSHSNDN 179 Query: 178 WNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTG 237 V LRYFN G + V Q+A+G F E G Sbjct: 180 VQ-VGLRYFNVYGPR---------EFYKEKTASMVLQLALGAM----AFKEVKLFEFGEQ 225 Query: 238 VRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGK-KIPY 294 +RD++++ D+ + ++ A++ K +YN+G S ++V +++ G K+ Y Sbjct: 226 LRDFVYIEDVIQANVKAMKAQK----SGVYNVGYSQARSYNEIVSILKEHLGDFKVTY 279 >1R66-A nrPDB Length = 337 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 87/345 (25%), Positives = 137/345 (39%), Gaps = 40/345 (11%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGY--LP----VVIDNFHNAFRGGGSLPESLRRVQELTG 57 ++LVTGGAG+IGSH V +LL Y +P +V+D+ A P Sbjct: 2 RLLVTGGAGFIGSHFVRQLLAGAYPDVPADEVIVLDSLTYAGNRANLAPVD-------AD 54 Query: 58 RSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLE 117 + F DI D G L R + A++HFA V S+ + N+ GT LL+ Sbjct: 55 PRLRFVHGDIRDAGLLARELRGVD--AIVHFAAESHVDRSIAGASVFTETNVQGTQTLLQ 112 Query: 118 IMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKT 177 GV +V S+ VYG+ E+ P +PY SK + + R Sbjct: 113 CAVDAGVGRVVHVSTDEVYGSIDSGSWTESSPL-EPNSPYAASKAGSDLVAR-------- 163 Query: 178 WNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMP-YVSQVAIGRREALNVFGNDYDTEDGT 236 R + C P P L+P +V+ + G L ++G DG Sbjct: 164 ---AYHRTYGLDVRITRCCNNYGPYQHPEKLIPLFVTNLLDG--GTLPLYG------DGA 212 Query: 237 GVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKI-PYK 295 VR+++H D +G AL + G IY++G G + ++ + + G + Sbjct: 213 NVREWVHTDDHCRG--IALVLAGGRAG-EIYHIGGGLELTNRELTGILLDSLGADWSSVR 269 Query: 296 VVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQN 340 VA R+G + + ELG+ + RW ++N Sbjct: 270 KVADRKGHDLRYSLDGGKIERELGYRPQVSFADGLARTVRWYREN 314 >1OC2-A nrPDB Length = 348 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 92/359 (25%), Positives = 138/359 (38%), Gaps = 51/359 (14%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + ++VTGGAG+IGS+ V Y+ + H + + ++ + G VE Sbjct: 5 KNIIVTGGAGFIGSNFV------HYVYNNHPDVHVTVLDKLTYAGNKANLEAILGDRVEL 58 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 DI D + +L K A++H+A S+ P + N GT LLE + + Sbjct: 59 VVGDIADAELVDKLAAKAD--AIVHYAAESHNDNSLNDPSPFIHTNFIGTYTLLEAARKY 116 Query: 123 GVKNLVFSSSATVYGNPQYLPLDEAHPTGG---------CTNPYGKSKFFIEEMIRDLCQ 173 ++ S+ VYG+ LPL E P G TN S + + DL Sbjct: 117 DIR-FHHVSTDEVYGD---LPLREDLPGHGEGPGEKFTAETNYNPSSPYSSTKAASDLIV 172 Query: 174 ADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDT- 232 K W +R F A S C NN PY R+ N+ Sbjct: 173 --KAW----VRSFG-VKATISNC--------SNNYGPYQHIEKFIPRQITNILAGIKPKL 217 Query: 233 -EDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKK 291 +G VRD+IH D + G A L K + I G VL+++ +EK K Sbjct: 218 YGEGKNVRDWIHTNDHSTGVWAILTKGRMGETYLIGADGEKNNKEVLELI--LEKMGQPK 275 Query: 292 IPYKVVARREGDVAACYANPSLAQEELGWTAAL-----GLDRMC------EDLWRWQKQ 339 Y V R G + S ++ELGWT GL+ +D W+ +K+ Sbjct: 276 DAYDHVTDRAGHDLRYAIDASKLRDELGWTPQFTDFSEGLEETIQWYTDNQDWWKAEKE 334 >2HUN-A nrPDB Length = 336 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 75/295 (25%), Positives = 132/295 (44%), Gaps = 44/295 (14%) Query: 4 KVLVTGGAGYIGSHTVLELLEA--GYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 K+LVTGG G+IGS+ + +LE + + ID G GS P +L+ +++ Sbjct: 5 KLLVTGGMGFIGSNFIRYILEKHPDWEVINIDKL-----GYGSNPANLKDLED--DPRYT 57 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLE-IMK 120 F + D+ D ++ L +K V+H A V S+ P + N+ GT LLE I + Sbjct: 58 FVKGDVADYELVKELVRKVD--GVVHLAAESHVDRSISSPEIFLHSNVIGTYTLLESIRR 115 Query: 121 AHGVKNLVFSSSATVYGNP---QYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKT 177 + V S+ VYG+ + D P ++PY +K + ++ + Sbjct: 116 ENPEVRFVHVSTDEVYGDILKGSFTENDRLMP----SSPYSATKAASDMLVLGWTRTYNL 171 Query: 178 WNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMP-YVSQVAIGRREALNVFGNDYDTEDGT 236 NA + R N G P P L+P + + ++G + + ++G G Sbjct: 172 -NASITRCTNNYG----------PYQFPEKLIPKTIIRASLGLK--IPIYGT------GK 212 Query: 237 GVRDYIHVVDLAKGHIAALRKLKEQCGCR-IYNLGTGTGYSVLQMVQAMEKASGK 290 VRD+++V D H+ A+ + + R IYN+ G + L++V+ + + GK Sbjct: 213 NVRDWLYVED----HVRAIELVLLKGESREIYNISAGEEKTNLEVVKIILRLMGK 263 >2Q1W-A nrPDB Length = 333 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 72/289 (24%), Positives = 115/289 (39%), Gaps = 51/289 (17%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 +KV +TG G IGSH LLE G V IDNF R E L+ LT F Sbjct: 22 KKVFITGICGQIGSHIAELLLERGDKVVGIDNFATGRR------EHLKDHPNLT-----F 70 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTI---QLLEIM 119 E I D + +L AV+H A S + P D+Y LT + +++ Sbjct: 71 VEGSIADHALVNQLIGDLQPDAVVHTAA------SYKDPDDWYNDTLTNCVGGSNVVQAA 124 Query: 120 KAHGVKNLVFSSSATVYG-NPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTW 178 K + V V+ +A YG P P+ HP + Y SK E+ + Sbjct: 125 KKNNVGRFVYFQTALCYGVKPIQQPVRLDHPRNPANSSYAISKSANEDYLE-----YSGL 179 Query: 179 NAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGV 238 + V R N G P+ + L + +++ G++ + Sbjct: 180 DFVTFRLANVVG----------PRNVSGPLPIFFQRLSEGKKCFVT-----------KAR 218 Query: 239 RDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKA 287 RD++ V DLA+ + A+ + G Y+ +GT ++ ++ A+ +A Sbjct: 219 RDFVFVKDLARATVRAV----DGVGHGAYHFSSGTDVAIKELYDAVVEA 263 >5UZH-A nrPDB Length = 345 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 84/350 (24%), Positives = 148/350 (42%), Gaps = 49/350 (14%) Query: 6 LVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEM 65 L+TG G GS+ LLE GY+ I ++F G E L + +T + Sbjct: 5 LITGITGQDGSYLAEFLLEKGYMVYGIIRRSSSFNTGRV--EHLYKDIHITKAKFKLLYG 62 Query: 66 DILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGV- 124 D+ D G L + K + + A V S + P V+ GT++LLE ++A G+ Sbjct: 63 DLTDTGNLISIIAKIKPDEIYNLAAQSHVKVSFEMPEYTANVDGIGTLRLLEAIRACGLE 122 Query: 125 KNLVF--SSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTW--NA 180 K F +S++ +YG Q +P E P +PY +K + ++ + +A + N Sbjct: 123 KKTKFYQASTSELYGLVQEVPQKETTPFYP-RSPYACAKLYSYWIVVNYREAYNMFALNG 181 Query: 181 VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD 240 +L FN H S I P + + V+++ +G ++ L + + D E RD Sbjct: 182 IL---FN----HES--IRRGPTFVTRKITMAVARIKLGLQDCL--YLGNLDAE-----RD 225 Query: 241 YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYK----V 296 + H AK ++ A+ + +Q R + + TG +SV + V+ G+ + +K Sbjct: 226 WGH----AKDYVEAMWLMLQQEQPRDFCVATGEKHSVREFVEKAFACIGQTVEWKGERGT 281 Query: 297 VAR-----------------REGDVAACYANPSLAQEELGWTAALGLDRM 329 V R +V +P+LA+ LGW + + + Sbjct: 282 VEEHGVVDGVVRVRVDPRYFRPTEVDQLLGDPTLAETVLGWKRKVSFEEL 331 >2Z95-A nrPDB Length = 345 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 79/354 (22%), Positives = 146/354 (41%), Gaps = 54/354 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQEL-TGRSVE 61 ++ L+TG G G++ LLE GY + A R G + R++EL V+ Sbjct: 4 KRALITGIRGQDGAYLAKLLLEKGY------EVYGADRRSGEF--ASWRLKELGIENDVK 55 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 MD+L+ + R +K V + A VG S ++P+ V+ G +++LE ++ Sbjct: 56 IIHMDLLEFSNIIRTIEKVQPDEVYNLAAQSFVGVSFEQPILTAEVDAIGVLRILEALRT 115 Query: 122 HGVKNLVF-SSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTW-- 178 + +S++ ++G Q +P E P +PY +K F + + +A + Sbjct: 116 VKPDTKFYQASTSEMFGKVQEIPQTEKTPF-YPRSPYAVAKLFGHWITVNYREAYNMFAC 174 Query: 179 NAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGV 238 + +L FN H S G + + + ++++ G ++ L V GN Sbjct: 175 SGIL---FN----HESPLRG--IEFVTRKITYSLARIKYGLQDKL-VLGN------LNAK 218 Query: 239 RDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPY---- 294 RD+ + A ++ A+ + +Q Y + TG ++V + V+ K +G I + Sbjct: 219 RDWGY----APEYVEAMWLMMQQPEPDDYVIATGETHTVREFVEKAAKIAGFDIEWVGEG 274 Query: 295 -----------KVVAR------REGDVAACYANPSLAQEELGWTAALGLDRMCE 331 KV+ R +V NP A ++LGW D + E Sbjct: 275 INEKGIDRNTGKVIVEVSEEFFRPAEVDILVGNPEKAMKKLGWKPRTTFDELVE 328 >1WVG-A nrPDB Length = 359 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 49/161 (30%), Positives = 75/161 (46%), Gaps = 11/161 (6%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 ++V VTG G+ GS L L E G ++ + SL E + R+ +L +E Sbjct: 10 KRVFVTGHTGFKGSWLSLWLTEMG---AIVKGYALDAPTVPSLFE-IVRLNDL----MES 61 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 DI D L+ ++ V H A V S ++P+ Y N+ GT+ LLE +K Sbjct: 62 HIGDIRDFEKLRSSIAEFKPEIVFHMAAQPLVRLSYEQPIKTYSTNVMGTVHLLETVKQV 121 Query: 123 G-VKNLVFSSSATVYGNPQYLP-LDEAHPTGGCTNPYGKSK 161 G +K +V +S Y N +++ E P GG +PY SK Sbjct: 122 GNIKAVVNITSDKCYDNREWVWGYRENEPMGGY-DPYSNSK 161 >1RKX-A nrPDB Length = 357 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 45/160 (28%), Positives = 68/160 (42%), Gaps = 9/160 (5%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 ++V VTG G+ G L L G + + SL E+ R ++ Sbjct: 10 KRVFVTGHTGFKGGWLSLWLQTMG---ATVKGYSLTAPTVPSLFETAR-----VADGMQS 61 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLE-IMKA 121 E DI DQ L +++ V H A V S +P++ Y N+ GT+ LLE I Sbjct: 62 EIGDIRDQNKLLESIREFQPEIVFHMAAQPLVRLSYSEPVETYSTNVMGTVYLLEAIRHV 121 Query: 122 HGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSK 161 GVK +V +S Y N +++ + G +PY SK Sbjct: 122 GGVKAVVNITSDKCYDNKEWIWGYRENEAMGGYDPYSNSK 161 >4EJ0-A nrPDB Length = 342 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 71/272 (26%), Positives = 113/272 (41%), Gaps = 35/272 (12%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVV-IDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 ++VTG AG+IG++ V L E G ++ +DN A + + L V+ E Sbjct: 15 LIVTGAAGFIGANLVKALNERGETRIIAVDNLTRA-----------DKFKNL----VDCE 59 Query: 64 EMDILDQGALQRLFKKYSF---MAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 D LD+ F + F AV H E+ + + N + +L+ Sbjct: 60 IDDYLDKTEFVERFARGDFGKVRAVFHEGACSDTMETDGRYM--MDNNFRYSRAVLDACL 117 Query: 121 AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA 180 A G + +++SSA +YG E N YG SKF +++IR + K+ A Sbjct: 118 AQGAQ-FLYASSAAIYGGSSRFV--EEREVEAPLNVYGYSKFLFDQVIRRVMPGAKSQIA 174 Query: 181 VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD 240 RYFN G S G +N + ++ + +FG G RD Sbjct: 175 G-FRYFNVYGPRESHK-GRMASVAFHNFNQFRAEGKV------KLFGEYSGYGPGEQTRD 226 Query: 241 YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTG 272 ++ V D+AK ++ E+ G I+NLGTG Sbjct: 227 FVSVEDVAKVNLYFFDH-PEKSG--IFNLGTG 255 >2PK3-A nrPDB Length = 321 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 67/344 (19%), Positives = 139/344 (40%), Gaps = 45/344 (13%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 + L+TG AG++G + L E ++ F + LP +VE Sbjct: 14 RALITGVAGFVGKYLANHLTEQN-----VEVFGTSRNNEAKLP------------NVEMI 56 Query: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHG 123 +DI+D ++++ + H A +V +S + N+ GT+ +L+ ++ Sbjct: 57 SLDIMDSQRVKKVISDIKPDYIFHLAAKSSVKDSWLNKKGTFSTNVFGTLHVLDAVRDSN 116 Query: 124 VKNLVFS-SSATVYGN--PQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA 180 + + + S+ YG P+ P+ E + + PYG SK + + R +A + Sbjct: 117 LDCRILTIGSSEEYGMILPEESPVSEENQLRPMS-PYGVSKASVGMLARQYVKA-YGMDI 174 Query: 181 VLLRYFNPTGAHAS-GCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVR 239 + R FN G S G + +D + + + ++E + GN VR Sbjct: 175 IHTRTFNHIGPGQSLGFVTQD-------FAKQIVDIEMEKQEPIIKVGN------LEAVR 221 Query: 240 DYIHVVDLAKGHIAALRKLKEQCGCR--IYNLGTGTGYSVLQMVQAMEKASGKKIPYKV- 296 D+ V D+ + + L Q G +YN+ +G G + ++ + + KI ++ Sbjct: 222 DFTDVRDIVQAYW-----LLSQYGKTGDVYNVCSGIGTRIQDVLDLLLAMANVKIDTELN 276 Query: 297 -VARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQ 339 + R +V + ++ GW + L++ ++ + +Q Sbjct: 277 PLQLRPSEVPTLIGSNKRLKDSTGWKPRIPLEKSLFEILQSYRQ 320 >1RPN-A nrPDB Length = 335 Score = 47.4 bits (111), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 81/345 (23%), Positives = 138/345 (40%), Gaps = 51/345 (14%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQEL-TGRS 59 M LVTG G G++ LLE GY H S ++ R++EL Sbjct: 13 MTRSALVTGITGQDGAYLAKLLLEKGY------RVHGLVARRSS--DTRWRLRELGIEGD 64 Query: 60 VEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIM 119 +++E+ D+ D ++QR K V + A VG S +P+ V+ G LLE + Sbjct: 65 IQYEDGDMADACSVQRAVIKAQPQEVYNLAAQSFVGASWNQPVTTGVVDGLGVTHLLEAI 124 Query: 120 KAHGVKNLVF-SSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTW 178 + + + +S++ ++G Q DE P +PYG +K + W Sbjct: 125 RQFSPETRFYQASTSEMFGLIQAERQDENTPFY-PRSPYGVAKLY------------GHW 171 Query: 179 NAVLLRYFNPTGAHASGCI---GEDP----QGIPNNLMPYVSQVAIGRREALNVFGNDYD 231 + + Y G HAS I E P + + + V+++ +G+++ L + D Sbjct: 172 --ITVNYRESFGLHASSGILFNHESPLRGIEFVTRKVTDAVARIKLGKQQELRLGNVD-- 227 Query: 232 TEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKK 291 RD+ A ++ A+ + +Q Y + TG +V M Q + G Sbjct: 228 -----AKRDW----GFAGDYVEAMWLMLQQDKADDYVVATGVTTTVRDMCQIAFEHVG-- 276 Query: 292 IPYKVVAR------REGDVAACYANPSLAQEELGWTAALGLDRMC 330 + Y+ + R +V NP+ AQ LGW LD + Sbjct: 277 LDYRDFLKIDPAFFRPAEVDVLLGNPAKAQRVLGWKPRTSLDELI 321 >1DB3-A nrPDB Length = 372 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 81/370 (21%), Positives = 139/370 (37%), Gaps = 71/370 (19%) Query: 6 LVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQEL------TGRS 59 L+TG G GS+ LLE GY H R S + RV + Sbjct: 5 LITGVTGQDGSYLAEFLLEKGY------EVHGIKRRASSF--NTERVDHIYQDPHTCNPK 56 Query: 60 VEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIM 119 D+ D L R+ ++ V + + V S + P V+ GT++LLE + Sbjct: 57 FHLHYGDLSDTSNLTRILREVQPDEVYNLGAMSHVAVSFESPEYTADVDAMGTLRLLEAI 116 Query: 120 KAHGV-KNLVF--SSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADK 176 + G+ K F +S++ +YG Q +P E P +PY +K + + + ++ Sbjct: 117 RFLGLEKKTRFYQASTSELYGLVQEIPQKETTPF-YPRSPYAVAKLYAYWITVNYRESYG 175 Query: 177 TW--NAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTED 234 + N +L FN H S GE + + ++ +A G L + D Sbjct: 176 MYACNGIL---FN----HESPRRGE--TFVTRKITRAIANIAQGLESCLYLGNMD----- 221 Query: 235 GTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPY 294 +RD+ H D K L++ + + + + TG YSV Q V+ G K+ + Sbjct: 222 --SLRDWGHAKDYVKMQWMMLQQEQPED----FVIATGVQYSVRQFVEMAAAQLGIKLRF 275 Query: 295 K--------------------------VVAR-----REGDVAACYANPSLAQEELGWTAA 323 + ++A R +V +P+ A E+LGW Sbjct: 276 EGTGVEEKGIVVSVTGHDAPGVKPGDVIIAVDPRYFRPAEVETLLGDPTKAHEKLGWKPE 335 Query: 324 LGLDRMCEDL 333 + L M ++ Sbjct: 336 ITLREMVSEM 345 >3M2P-A nrPDB Length = 311 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 73/338 (21%), Positives = 134/338 (39%), Gaps = 54/338 (15%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M+ K+ VTGG G++G + V + G P+++ R G+ + + + R Sbjct: 1 MSLKIAVTGGTGFLGQYVVESIKNDGNTPIILT------RSIGN-----KAINDYEYRVS 49 Query: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 ++ D+++Q AV+H A + Q + + N T L + Sbjct: 50 DYTLEDLINQLN--------DVDAVVHLAATRG----SQGKISEFHDNEILTQNLYDACY 97 Query: 121 AHGVKNLVFSSSATVYGNPQYLPLDEAH-PTGGCTNPYGKSKFFIEEMIRDLCQADKTWN 179 + + N+V++S+ + Y + LP +E P YG SK E I ++ K Sbjct: 98 ENNISNIVYASTISAYSDETSLPWNEKELPLPDLM--YGVSKLACEH-IGNIYSRKKGLC 154 Query: 180 AVLLRYFNPTGAHASGCIGEDPQGIPNNLM--PYVSQVAIGRREALNVFGNDYDTEDGTG 237 LR+ AH G NN M + Q G + L+ + Sbjct: 155 IKNLRF-----AHLYGF------NEKNNYMINRFFRQAFHGEQLTLHA--------NSVA 195 Query: 238 VRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKK--IPYK 295 R++++ D AK I A LK++ +N+G+G + ++ + A G K + K Sbjct: 196 KREFLYAKDAAKSVIYA---LKQEKVSGTFNIGSGDALTNYEVANTINNAFGNKDNLLVK 252 Query: 296 VVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDL 333 EG + + Y + S A+E L ++ E++ Sbjct: 253 NPNANEG-IHSSYMDSSKAKELLDFSTDYNFATAVEEI 289 >6GPK-A nrPDB Length = 373 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 74/362 (20%), Positives = 144/362 (39%), Gaps = 54/362 (14%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M L+TG G GS+ LLE GY I ++F G + + Q ++ Sbjct: 23 MRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSF-NTGRIEHLYKNPQAHIEGNM 81 Query: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 + D+ D L ++ + + + V S V+ GT++LL+ +K Sbjct: 82 KLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVK 141 Query: 121 AHGVKNLVF---SSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKT 177 G+ N V +S++ +YG Q +P E P +PYG +K + ++ + +A Sbjct: 142 TCGLINSVKFYQASTSQLYGKVQEIPQKETTPFYP-RSPYGAAKLYAYWIVVNFREAYNL 200 Query: 178 W--NAVLLRYFNP-TGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTED 234 + N +L + +P GA+ + + V+++ +G+ E ++ D Sbjct: 201 FAVNGILFNHESPRRGANF----------VTRKISRSVAKIYLGQLECFSLGNLD----- 245 Query: 235 GTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPY 294 RD+ H AK ++ A+ + + + + TG +SV + V+ GK I + Sbjct: 246 --AKRDWGH----AKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVW 299 Query: 295 KVVARREGDVAAC-------------YANP----------SLAQEELGWTAALGLDRMCE 331 + + E +V C Y P + A+++L W + D + Sbjct: 300 E--GKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVR 357 Query: 332 DL 333 ++ Sbjct: 358 EM 359 >4BKP-A nrPDB Length = 336 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 65/263 (24%), Positives = 104/263 (39%), Gaps = 41/263 (15%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 ++LVTGG+G +G VV D G LP V + Sbjct: 24 RILVTGGSGLVGK---------AIQKVVAD--------GAGLPGE-------DWVFVSSK 59 Query: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLK-AVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 + D+ D + LF+K VIH A + + +++ LD++R N+ +L Sbjct: 60 DADLTDTAQTRALFEKVQPTHVIHLAAMVGGLFRNIKYNLDFWRKNVHMNDNVLHSAFEV 119 Query: 123 GVKNLVFSSSATVYGNPQYLPLDEAH----PTGGCTNPYGKSKFFIEEMIRD-LCQADKT 177 G + +V S ++ + P+DE P Y +K I+ R Q T Sbjct: 120 GARKVVSCLSTCIFPDKTTYPIDETMIHNGPPHNSNFGYSYAKRMIDVQNRAYFQQYGCT 179 Query: 178 WNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTG 237 + AV+ N G H + I ED +P + + +A AL V+G G Sbjct: 180 FTAVIPT--NVFGPHDNFNI-EDGHVLPG--LIHKVHLAKSSGSALTVWGT------GNP 228 Query: 238 VRDYIHVVDLAKGHIAALRKLKE 260 R +I+ +DLA+ I LR+ E Sbjct: 229 RRQFIYSLDLAQLFIWVLREYNE 251 >1GFS-A nrPDB Length = 321 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 73/323 (22%), Positives = 120/323 (37%), Gaps = 37/323 (11%) Query: 43 GSLPESLRRVQELTGRSVEF-----EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGES 97 G + ++RR E G VE +E+++LD A+ F V + A K G Sbjct: 13 GMVGSAIRRQLEQRG-DVELVLRTRDELNLLDSRAVHDFFASERIDQV-YLAAAKVGGIV 70 Query: 98 VQK--PLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTN 155 P D+ N+ ++ + V L+F S+ +Y P+ E+ G Sbjct: 71 ANNTYPADFIYQNMMIESNIIHAAHQNDVNKLLFLGSSCIYPKLAKQPMAESELLQGTLE 130 Query: 156 PYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQV 215 P + + LC++ R PT + G +N P S V Sbjct: 131 PTNEPYAIAKIAGIKLCESYNRQYGRDYRSVMPTNLY----------GPHDNFHPSNSHV 180 Query: 216 --AIGRREALNVFGNDYDTE---DGTGVRDYIHVVDLAKGHIAALRKLKE------QCGC 264 A+ RR N D GT +R+++HV D+A I + E Q Sbjct: 181 IPALLRRFHEATAQNAPDVVVWGSGTPMREFLHVDDMAAASIHVMELAHEVWLENTQPML 240 Query: 265 RIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVV---ARREGDVAACYANPSLAQEELGWT 321 N+GTG ++ ++ Q + K G K +VV ++ +G L Q LGW Sbjct: 241 SHINVGTGVDCTIRELAQTIAKVVGYK--GRVVFDASKPDGTPRKLLDVTRLHQ--LGWY 296 Query: 322 AALGLDRMCEDLWRWQKQNPSGF 344 + L+ ++W +N F Sbjct: 297 HEISLEAGLASTYQWFLENQDRF 319 >2NNL-D nrPDB Length = 337 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 48/163 (29%), Positives = 73/163 (44%), Gaps = 39/163 (23%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTG---- 57 +E V VTG +G+IGS V+ LLE GY R P ++++V+ L Sbjct: 5 SETVCVTGASGFIGSWLVMRLLERGY----------TVRATVRDPTNVKKVKHLLDLPKA 54 Query: 58 -RSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVN-----LTG 111 + + D+ D+G+ K + V H V P+D+ + + Sbjct: 55 ETHLTLWKADLADEGSFDEAIKGCT--GVFH----------VATPMDFESKDPENEVIKP 102 Query: 112 TIQ-LLEIMK----AHGVKNLVFSSSA-TVYGNPQYLPL-DEA 147 TI+ +L IMK A V+ LVF+SSA TV LP+ DE+ Sbjct: 103 TIEGMLGIMKSCAAAKTVRRLVFTSSAGTVNIQEHQLPVYDES 145 >5YWN-A nrPDB Length = 334 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 79/313 (25%), Positives = 127/313 (40%), Gaps = 46/313 (14%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M V V+G GY+ + +L GY V+ + + +G +++L G Sbjct: 1 MTTSVFVSGATGYLAQQIIALVLSKGYK--VVGSVRSEEKGAN--------LKKLYGDDF 50 Query: 61 EFEEMDILDQ-GALQRLFKKYSFMAV-IHFAG-LKAVGESVQKPLDYYRVNLTGTIQLLE 117 +E + +L+Q GA KK+ + + +H A + E +K + +N GT +L+ Sbjct: 51 SYEVVKVLEQKGAFDEALKKHPEVTIFLHTASPVTFEVEDTEKEILIPAIN--GTKYVLQ 108 Query: 118 IMK--AHGVKNLVFSSSATVYGNPQYL-----PLDEA---------HPTGGCTNPYGKSK 161 +K A + +V++SS P+ L L EA T G +G SK Sbjct: 109 SIKDVAPQITRVVYTSSVVAMSVPEELGSPDVVLSEASWSSLSYEQSKTHGVLAYFG-SK 167 Query: 162 FFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRRE 221 F E + + +K A L NP E+ +G N+ V+ V Sbjct: 168 QFAERAAWEFVEQEKPNFA--LSTVNPVYIFGPQAKDEEVKGTLNHSAEMVNSVL----- 220 Query: 222 ALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTG-TGYSVLQM 280 LN D D TG +I V D+AK H+AA K E G R+ T G ++L + Sbjct: 221 KLN---KDDDVPATTGT--FIDVRDVAKAHLAAFEK-DEAKGERLLLSNTRFNGQTLLDV 274 Query: 281 VQAMEKASGKKIP 293 V+ K+P Sbjct: 275 VRKNFPQLADKLP 287 >3WMX-A nrPDB Length = 358 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 36/138 (26%), Positives = 62/138 (44%), Gaps = 24/138 (17%) Query: 4 KVLVTGGAGYIGSHTVLELLEA-GYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 K+L+ G G IGS L L E G V+ + +P TGR V Sbjct: 27 KILIVGANGQIGSELALALAERYGRTNVITSDV---------VP---------TGRHVHL 68 Query: 63 --EEMDILDQGALQRLFKKYSFMAV-IHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIM 119 E ++ D+G L + +++ V + A L A GE + P + +N+T + +LE+ Sbjct: 69 THEMLNATDRGELATVVERHGITQVYLLAAALSATGE--KAPQWAWNLNMTSLLNVLELA 126 Query: 120 KAHGVKNLVFSSSATVYG 137 + G++ + + SS +G Sbjct: 127 RQTGLERVFWPSSIAAFG 144 >3SLK-A nrPDB Length = 795 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 43/148 (29%), Positives = 68/148 (45%), Gaps = 17/148 (11%) Query: 2 AEKVLVTGGAGYIGSHTVLEL-LEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELT--GR 58 A VLVTGG G +G+ L +E G + N R G + + V +LT G Sbjct: 530 AGTVLVTGGTGALGAEVARHLVIERG-----VRNLVLVSRRGPAASGAAELVAQLTAYGA 584 Query: 59 SVEFEEMDILDQGALQRLF----KKYSFMAVIHFAGL--KAVGES--VQKPLDYYRVNLT 110 V + D+ D+ L ++ ++ AV+H AG+ V ES V++ R + Sbjct: 585 EVSLQACDVADRETLAKVLASIPDEHPLTAVVHAAGVLDDGVSESLTVERLDQVLRPKVD 644 Query: 111 GTIQLLEIMKAHGVKNLVFSSSATVYGN 138 G LLE++ V ++FSS + V G+ Sbjct: 645 GARNLLELIDPD-VALVLFSSVSGVLGS 671 >1EQ2-A nrPDB Length = 310 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 66/295 (22%), Positives = 119/295 (40%), Gaps = 37/295 (12%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPV-VIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 ++VTGGAG+IGS+ V L + G + V+DN + + + L + + Sbjct: 2 IIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDGTKFVNLV--DLNIADYMDKEDFLIQ 59 Query: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHG 123 M + G ++ +F + + + + G + + Q + L I L Sbjct: 60 IMAGEEFGDVEAIFHEGACSSTTEWDGKYMMDNNYQYSKELLHYCLEREIPFL------- 112 Query: 124 VKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLL 183 ++SSA YG + E+ N YG SKF +E +R + + V Sbjct: 113 -----YASSAATYGG-RTSDFIESREYEKPLNVYGYSKFLFDEYVRQILPEANS-QIVGF 165 Query: 184 RYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIH 243 RYFN G E +G ++ +++ + E+ +F + + RD+++ Sbjct: 166 RYFNVYGPR------EGHKGSMASVAFHLN-TQLNNGESPKLFEGSENFK-----RDFVY 213 Query: 244 VVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAM----EKASGKKIPY 294 V D+A ++ L E I+NLGTG S + A +K + IP+ Sbjct: 214 VGDVADVNLWFL----ENGVSGIFNLGTGRAESFQAVADATLAYHKKGQIEYIPF 264 >3RFT-A nrPDB Length = 267 Score = 37.0 bits (84), Expect = 0.013, Method: Compositional matrix adjust. Identities = 36/122 (29%), Positives = 52/122 (42%), Gaps = 22/122 (18%) Query: 56 TGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLD-YYRVNLTGTIQ 114 G + E + D+ D A+ + ++H G+ SV+KP + + N+ G Sbjct: 41 AGPNEECVQCDLADANAVNAMVAGCD--GIVHLGGI-----SVEKPFEQILQGNIIGLYN 93 Query: 115 LLEIMKAHGVKNLVFSSSATVYGNPQYLPLDE-------AHPTGGCTNPYGKSKFFIEEM 167 L E +AHG +VF+SS G Y P E A P G YG SK F E + Sbjct: 94 LYEAARAHGQPRIVFASSNHTIG---YYPQTERLGPDVPARPDGL----YGVSKCFGENL 146 Query: 168 IR 169 R Sbjct: 147 AR 148 >4R1U-A nrPDB Length = 349 Score = 36.6 bits (83), Expect = 0.018, Method: Compositional matrix adjust. Identities = 39/142 (27%), Positives = 60/142 (42%), Gaps = 22/142 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLR--RVQELTG--R 58 + V VTG G+I S V LLE GY RG PE + ++EL G Sbjct: 28 QTVCVTGAGGFIASWLVKLLLERGY----------TVRGTVRNPEDPKNGHLKELEGARE 77 Query: 59 SVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEI 118 + ++D+LD ++Q + + V H A P + + GT ++ Sbjct: 78 RLTLHKVDLLDLQSIQSVV--HGCHGVFHTA-----SPVTDNPDEMLEPAVNGTKNVIIA 130 Query: 119 MKAHGVKNLVFSSS-ATVYGNP 139 V+ +VF+SS TVY +P Sbjct: 131 SAEAKVRRVVFTSSIGTVYMDP 152 >2X86-A nrPDB Length = 357 Score = 36.2 bits (82), Expect = 0.021, Method: Compositional matrix adjust. Identities = 65/295 (22%), Positives = 119/295 (40%), Gaps = 37/295 (12%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPV-VIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 ++VTGGAG+IGS+ V L + G + V+DN + + + L + + Sbjct: 49 IIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDGTKFVNLV--DLNIADYMDKEDFLIQ 106 Query: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHG 123 M + G ++ +F + + + + G + + Q + L I L Sbjct: 107 IMAGEEFGDVEAIFHEGACSSTTEWDGKYMMDNNYQYSKELLHYCLEREIPFL------- 159 Query: 124 VKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLL 183 ++SSA YG + E+ N +G SKF +E +R + + V Sbjct: 160 -----YASSAATYGG-RTSDFIESREYEKPLNVFGYSKFLFDEYVRQIL-PEANSQIVGF 212 Query: 184 RYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIH 243 RYFN G E +G ++ +++ + E+ +F + + RD+++ Sbjct: 213 RYFNVYGPR------EGHKGSMASVAFHLN-TQLNNGESPKLFEGSENFK-----RDFVY 260 Query: 244 VVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAM----EKASGKKIPY 294 V D+A ++ L E I+NLGTG S + A +K + IP+ Sbjct: 261 VGDVADVNLWFL----ENGVSGIFNLGTGRAESFQAVADATLAYHKKGQIEYIPF 311 >5U9C-A nrPDB Length = 292 Score = 36.2 bits (82), Expect = 0.022, Method: Compositional matrix adjust. Identities = 48/188 (25%), Positives = 78/188 (41%), Gaps = 42/188 (22%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVID-NFHNAFRGGGSLPESLRRVQELTGRS 59 M K+L+TGG G +G++ L + Y +V + N N S+PE++ Sbjct: 4 MKRKILITGGTGMLGAYVTSALKDTDYNVIVTERNTLNL-----SVPEAIFSY------- 51 Query: 60 VEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIM 119 + E+ D+ ++HFA V ++P N T Q+ + Sbjct: 52 ITAEKPDV-----------------ILHFAAETDVDLCEREPARAGIYNHLATEQIAQAA 94 Query: 120 KAHGVKNLVFSSSATVYGNP---QYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADK 176 K G L++ SS+ V+G Y LD P N YG+SK E +R+ C Sbjct: 95 KFCGAW-LLYLSSSNVFGGEGKLSYNELDIPLP----MNYYGRSKLIGESSVRNAC---- 145 Query: 177 TWNAVLLR 184 T N +++R Sbjct: 146 TNNHLIIR 153 >5B6K-A nrPDB Length = 366 Score = 35.0 bits (79), Expect = 0.053, Method: Compositional matrix adjust. Identities = 74/281 (26%), Positives = 109/281 (38%), Gaps = 53/281 (18%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 V V+G G+I H V +LL+ Y VI + +A +G + L+ V G +E Sbjct: 24 VFVSGATGFIAQHVVRQLLDQNYK--VIGSVRSAEKG-----DHLKNVI-FKGGDFNYEI 75 Query: 65 M-DILDQGALQRLFKKY--SFMAVIHFAG-LKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 + DI D A +F+K+ V+H A ++K L VN GT +LE +K Sbjct: 76 VKDISDPTAFDHVFEKHGKDIKVVLHTASPFHFNTTDIEKDLLIPAVN--GTKGILESIK 133 Query: 121 ---AHGVKNLVFSSS-----ATV---YGNPQYLPLDE------------AHPTGGCTNPY 157 A V+ +V +SS +TV Y + E + P G Y Sbjct: 134 KYAAQTVERVVVTSSFAANTSTVDMFYAKDSSKTITEESWNQDTWESCQSDPIRG----Y 189 Query: 158 GKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYV-SQVA 216 SK F E+ D A+K L NP E + I N + S V Sbjct: 190 CGSKKFAEKAAWDFYNANKDSVKFKLSIINPVYVFGPQNYVEPGKKILNTSSEVINSLVH 249 Query: 217 IGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRK 257 + + + L F +I V D+AK HI A +K Sbjct: 250 LKKDDPLPEFAG-----------GHIDVRDVAKAHILAFQK 279 >4KTT-E nrPDB Length = 327 Score = 33.5 bits (75), Expect = 0.14, Method: Compositional matrix adjust. Identities = 40/161 (24%), Positives = 67/161 (41%), Gaps = 28/161 (17%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 +VLVTG G +G E + +N+H G G RR + +FE Sbjct: 23 RVLVTGATGLLGRAVHKEFQQ--------NNWHAV--GCG-----FRRARP------KFE 61 Query: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHG 123 ++++LD A+ + + ++H A + +P ++N+ + L + A G Sbjct: 62 QVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNLAKEAAAVG 121 Query: 124 VKNLVFSSSATVYG--NPQYLPLDEAHPTGGCTNPYGKSKF 162 L++ SS V+ NP Y D P N YGK+K Sbjct: 122 AF-LIYISSDYVFDGTNPPYREEDIPAP----LNLYGKTKL 157 >1ZZE-A nrPDB Length = 342 Score = 33.5 bits (75), Expect = 0.14, Method: Compositional matrix adjust. Identities = 37/130 (28%), Positives = 51/130 (39%), Gaps = 13/130 (10%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQ-ELTGRSVEFE 63 VLVTG G++ SH V +LLE GY R L +R + GR Sbjct: 14 VLVTGANGFVASHVVEQLLEHGY------KVRGTARSASKLANLQKRWDAKYPGRFETAV 67 Query: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH- 122 D+L QGA + K + V H A + + + + GT+ L A Sbjct: 68 VEDMLKQGAYDEVIKGAA--GVAHIASVVSFSNKYD---EVVTPAIGGTLNALRAAAATP 122 Query: 123 GVKNLVFSSS 132 VK V +SS Sbjct: 123 SVKRFVLTSS 132 >5IZ4-A nrPDB Length = 271 Score = 32.3 bits (72), Expect = 0.29, Method: Compositional matrix adjust. Identities = 18/46 (39%), Positives = 26/46 (56%), Gaps = 1/46 (2%) Query: 6 LVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRR 51 ++TG A IG+ T L +AG+ V I NF ++ R S E+L R Sbjct: 18 VITGSASGIGAATALRFAQAGW-SVAIGNFDDSTRDAASTVEALCR 62 >4AVY-A nrPDB Length = 242 Score = 32.0 bits (71), Expect = 0.44, Method: Compositional matrix adjust. Identities = 26/88 (29%), Positives = 38/88 (43%), Gaps = 21/88 (23%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVI----DNFHNAFRGGGSLPESLRRVQELTGR 58 ++VLVTGG+ IG+ ++ E G V + D H P R Sbjct: 12 QQVLVTGGSSGIGAAIAMQFAELGAEVVALGLDADGVHA--------PRHPR-------- 55 Query: 59 SVEFEEMDILDQGALQRLFKKYSFMAVI 86 + EE+DI D LQRLF+ + V+ Sbjct: 56 -IRREELDITDSQRLQRLFEALPRLDVL 82 >2GPY-A nrPDB Length = 233 Score = 31.6 bits (70), Expect = 0.48, Method: Compositional matrix adjust. Identities = 17/45 (37%), Positives = 26/45 (57%), Gaps = 1/45 (2%) Query: 244 VVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKAS 288 ++DL G + L LK RI +GT GYS ++M QA+ +A+ Sbjct: 37 IMDLL-GMESLLHLLKMAAPARILEIGTAIGYSAIRMAQALPEAT 80 >4PVC-A nrPDB Length = 342 Score = 31.6 bits (70), Expect = 0.53, Method: Compositional matrix adjust. Identities = 65/289 (22%), Positives = 104/289 (35%), Gaps = 55/289 (19%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 V V+G G+I H V LL+ Y + G E + E G + +F Sbjct: 3 VFVSGANGFIAQHIVDLLLKEDYKVI----------GSARSQEKAENLTEAFGNNPKFSM 52 Query: 65 M---DILDQGALQRLFKKY--SFMAVIHFA--------------------GLKAVGESVQ 99 DI A +F+K+ V+H A G+K + S++ Sbjct: 53 EVVPDISKLDAFDHVFQKHGKDIKIVLHTASPFCFDITDSERDLLIPAVNGVKGILHSIK 112 Query: 100 K--PLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPY 157 K RV LT + + M K+L F+ + NP ++ P N Y Sbjct: 113 KYAADSVERVVLTSSYAAVFDMAKENDKSLTFNEES---WNPATWESCQSDPV----NAY 165 Query: 158 GKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAI 217 SK F E+ + + ++ L NP +D + N V+ + Sbjct: 166 CGSKKFAEKAAWEFLEENRDSVKFELTAVNPVYVFGPQMFDKDVKKHLNTSCELVNSL-- 223 Query: 218 GRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRI 266 +++ D E G YI V D+AK H+ A +K +E G R+ Sbjct: 224 -----MHLSPEDKIPELFGG---YIDVRDVAKAHLVAFQK-RETIGQRL 263 >2P4H-X nrPDB Length = 322 Score = 31.2 bits (69), Expect = 0.66, Method: Compositional matrix adjust. Identities = 35/138 (25%), Positives = 59/138 (42%), Gaps = 20/138 (14%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 +V VTGG G++GS + LLE GY + + R PE R V LT E Sbjct: 3 RVCVTGGTGFLGSWIIKSLLENGY------SVNTTIRAD---PERKRDVSFLTNLPGASE 53 Query: 64 EMDILDQGALQRLFKKYSFMAVIH-----FAGLKAVGESVQKPLDYY-RVNLTGTIQLLE 117 ++ + L SF A I F + +V +P + + + G + +L+ Sbjct: 54 KLHFFNAD----LSNPDSFAAAIEGCVGIFHTASPIDFAVSEPEEIVTKRTVDGALGILK 109 Query: 118 -IMKAHGVKNLVFSSSAT 134 + + VK +++SS + Sbjct: 110 ACVNSKTVKRFIYTSSGS 127 >4R1T-A nrPDB Length = 337 Score = 30.8 bits (68), Expect = 1.0, Method: Compositional matrix adjust. Identities = 38/144 (26%), Positives = 55/144 (38%), Gaps = 22/144 (15%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLR--RVQELTG--RSV 60 V VTG G+I S V LLE GY RG P+ + ++EL G + Sbjct: 13 VCVTGAGGFIASWLVKILLEKGY----------TVRGTVRNPDDPKNGHLRELEGAKERL 62 Query: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 + D+LD +L+ V H A P + GT ++ Sbjct: 63 TLCKADLLDYQSLREAINGCD--GVFHTA-----SPVTDDPEQMVEPAVIGTKNVINAAA 115 Query: 121 AHGVKNLVFSSS-ATVYGNPQYLP 143 V+ +VF+SS VY +P P Sbjct: 116 EANVRRVVFTSSIGAVYMDPNRDP 139 >4J2O-A nrPDB Length = 363 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 31/133 (23%), Positives = 56/133 (42%), Gaps = 11/133 (8%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 +L+TGG G G+ + LE + I F + +R+ + ++F Sbjct: 26 LLITGGTGSFGNAVLKRFLETDIKEIRI------FSRDEKKQDDMRK--KYHSAKLKFYI 77 Query: 65 MDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGV 124 D+ D ++ + + + H A LK V P++ + N+ GT +LE + V Sbjct: 78 GDVRDYNSILNATRGVDY--IYHAAALKQVPSCEFHPMEAVKTNVLGTENVLEAAIQNHV 135 Query: 125 KNLV-FSSSATVY 136 K +V S+ VY Sbjct: 136 KRVVCLSTDKAVY 148 >3PXX-A nrPDB Length = 287 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 35/122 (28%), Positives = 51/122 (41%), Gaps = 14/122 (11%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQEL------TGR 58 VLVTGGA G ++L E G ++ D H+ L S R ++E TGR Sbjct: 13 VLVTGGARGQGRSHAVKLAEEGADIILFDICHDIETNEYPLATS-RDLEEAGLEVEKTGR 71 Query: 59 SVEFEEMDILDQGALQRLFKKY-----SFMAVIHFAGLKAVGE--SVQKPLDYYRVNLTG 111 E+D+ D+ A+ R V+ AG+ +G VQ D + V+ G Sbjct: 72 KAYTAEVDVRDRAAVSRELANAVAEFGKLDVVVANAGICPLGAHLPVQAFADAFDVDFVG 131 Query: 112 TI 113 I Sbjct: 132 VI 133 >2QYS-A nrPDB Length = 318 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 13/27 (48%), Positives = 18/27 (66%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGY 27 M K+L+ GG GYIG+H V L+ G+ Sbjct: 10 MKSKILIFGGTGYIGNHMVKGSLKLGH 36 >1QT1-A nrPDB Length = 387 Score = 29.6 bits (65), Expect = 2.3, Method: Compositional matrix adjust. Identities = 16/40 (40%), Positives = 22/40 (55%) Query: 33 DNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGA 72 D F +A RG ES+RR+ EL V F + D++ GA Sbjct: 23 DPFGDATRGALDPAESVRRLAELGAHGVTFHDDDLIPFGA 62 >4WO8-A nrPDB Length = 716 Score = 29.3 bits (64), Expect = 2.7, Method: Compositional matrix adjust. Identities = 16/52 (30%), Positives = 22/52 (42%), Gaps = 9/52 (17%) Query: 118 IMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIR 169 I HGVK+ F A +G+ LP + PTG KF + +R Sbjct: 444 ICDYHGVKDSAFKHPAPTFGDLSKLPFGDLDPTG---------KFIVSTRVR 486 >4F9J-A nrPDB Length = 618 Score = 28.9 bits (63), Expect = 3.1, Method: Compositional matrix adjust. Identities = 14/26 (53%), Positives = 14/26 (53%) Query: 22 LLEAGYLPVVIDNFHNAFRGGGSLPE 47 L E GY PV I A RGG LPE Sbjct: 44 LRENGYQPVSIAQIREAHRGGKPLPE 69 >3VUS-A nrPDB Length = 268 Score = 28.9 bits (63), Expect = 3.3, Method: Compositional matrix adjust. Identities = 14/26 (53%), Positives = 14/26 (53%) Query: 22 LLEAGYLPVVIDNFHNAFRGGGSLPE 47 L E GY PV I A RGG LPE Sbjct: 40 LRENGYQPVSIAQIREAHRGGKPLPE 65 >1HE4-A nrPDB Length = 206 Score = 28.9 bits (63), Expect = 3.4, Method: Compositional matrix adjust. Identities = 35/142 (24%), Positives = 56/142 (39%), Gaps = 24/142 (16%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLP-ESLRRVQELTGRSVE 61 +K+ + G G G T+ + ++AGY V+ R LP E R + G ++ Sbjct: 4 KKIAIFGATGQTGLTTLAQAVQAGYEVTVL------VRDSSRLPSEGPRPAHVVVGDVLQ 57 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 ++D G AVI G + L V G ++ MKA Sbjct: 58 AADVDKTVAGQ----------DAVIVLLGTR-------NDLSPTTVMSEGARNIVAAMKA 100 Query: 122 HGVKNLVFSSSATVYGNPQYLP 143 HGV +V +SA + +P +P Sbjct: 101 HGVDKVVACTSAFLLWDPTKVP 122 >4KMS-A nrPDB Length = 249 Score = 28.9 bits (63), Expect = 3.7, Method: Compositional matrix adjust. Identities = 18/37 (48%), Positives = 21/37 (56%), Gaps = 1/37 (2%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHN 37 M+E +VTGG IG T LEL G L VV + F N Sbjct: 9 MSEIAIVTGGTRGIGKATALELKNKG-LTVVANFFSN 44 >2B3T-A nrPDB Length = 276 Score = 28.5 bits (62), Expect = 4.4, Method: Compositional matrix adjust. Identities = 15/27 (55%), Positives = 18/27 (66%), Gaps = 1/27 (3%) Query: 254 ALRKLKEQCGCRIYNLGTGTGYSVLQM 280 AL +L EQ CRI +LGTGTG L + Sbjct: 102 ALARLPEQ-PCRILDLGTGTGAIALAL 127 >5ILO-A nrPDB Length = 271 Score = 28.5 bits (62), Expect = 4.7, Method: Compositional matrix adjust. Identities = 38/148 (25%), Positives = 68/148 (45%), Gaps = 21/148 (14%) Query: 6 LVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEM 65 +VTGGAG IG +LL AG V I + + +L E ++ +SV +M Sbjct: 19 VVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQD------NLEEFVKLRAAHPTQSVMIIKM 72 Query: 66 DILDQGALQRLFKKYS-----FMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQ-LLEIM 119 D+ ++ ++ +++ + V++ AG+ + VQ+ L VNL G I L + Sbjct: 73 DVANKKGVEATYEEIAKTFGNIDIVVNVAGIFN-DKDVQRTL---LVNLGGIINSTLSAL 128 Query: 120 KAHGVKN-----LVFSSSATVYGNPQYL 142 G N +V + S+ V +P ++ Sbjct: 129 PYMGKDNGGKGGIVVNMSSVVGLDPMFI 156 >6AQY-A nrPDB Length = 341 Score = 28.5 bits (62), Expect = 4.8, Method: Compositional matrix adjust. Identities = 28/134 (20%), Positives = 57/134 (42%), Gaps = 7/134 (5%) Query: 43 GSLPESLRRVQELTGRSVEF--EEMDILDQGALQRLFKKYSFMAVIHFAGLK-AVGESVQ 99 G E + + +++ G+ V ++ D+ D A ++ F+KY VIH A + +++ Sbjct: 37 GKAVEHIVKKEQIKGKWVFLGSKDGDLRDADACKQPFEKYRPTYVIHLAAFVGGLFKNMN 96 Query: 100 KPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAH----PTGGCTN 155 + ++ N+ +L GVK + S V+ + P+ E P N Sbjct: 97 FKVSFWLDNVNMNNNILTCCYDFGVKKTISCLSTCVFPDKIEYPITEEKLHEGPPHFSNN 156 Query: 156 PYGKSKFFIEEMIR 169 Y +K ++ + R Sbjct: 157 AYAYAKRMLDMLGR 170 >2X9N-A nrPDB Length = 288 Score = 27.7 bits (60), Expect = 7.3, Method: Compositional matrix adjust. Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 2/50 (4%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRR 51 A +VTG A IG ++L + GY V+ ++HN+ SL + L + Sbjct: 23 APAAVVTGAAKRIGRAIAVKLHQTGYRVVI--HYHNSAEAAVSLADELNK 70 >6GCS-E nrPDB Length = 375 Score = 27.7 bits (60), Expect = 7.4, Method: Compositional matrix adjust. Identities = 31/128 (24%), Positives = 56/128 (43%), Gaps = 19/128 (14%) Query: 7 VTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGR--SVEFEE 64 V G G++GS+ +L + G VV +R E +R ++TG V F E Sbjct: 58 VFGANGFLGSYLTAKLAKHGTTVVV------PYRE-----EMAKRHLKVTGDLGVVNFLE 106 Query: 65 MDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGV 124 MD+ + ++ + V++ G E K +YY V++ G ++ E +K H + Sbjct: 107 MDLRNLESIDEAVRHSDI--VVNLIG----REYETKNFNYYDVHVEGARRIAEAVKKHNI 160 Query: 125 KNLVFSSS 132 + S+ Sbjct: 161 ARYIHVSA 168 >4WPG-A nrPDB Length = 289 Score = 27.7 bits (60), Expect = 8.0, Method: Compositional matrix adjust. Identities = 26/109 (23%), Positives = 48/109 (44%), Gaps = 11/109 (10%) Query: 59 SVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAV--GESVQKPLDYYRVNLTGTIQLL 116 +V+ EMDI ++ ++ +F + V H A AV E K L+ +N+TG+ + Sbjct: 33 AVDVAEMDITNEDKVEAVFAQVKPTLVYHCAAYTAVDAAEDEGKALN-EAINVTGSENIA 91 Query: 117 EIMKAHGVKNLVFSSSATVYGNP----QYLPLDEAHPTGGCTNPYGKSK 161 + +G + S+ GN +++ D P YG++K Sbjct: 92 KACGKYGATLVYISTDYVFDGNKPVGQEWVETDHPDP----KTEYGRTK 136 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1I3M-A nrPDB 489 e-139 1UDA-A nrPDB 411 e-115 1Z45-A nrPDB 391 e-109 3ENK-A nrPDB 386 e-108 4LIS-A nrPDB 386 e-108 2C20-A nrPDB 339 1e-93 1GY8-A nrPDB 329 2e-90 4WOK-A nrPDB 319 8e-88 5UZH-A nrPDB 285 3e-77 6GPK-A nrPDB 273 8e-74 6BI4-A nrPDB 272 1e-73 1KEU-A nrPDB 272 2e-73 1R66-A nrPDB 267 6e-72 6BWL-A nrPDB 266 8e-72 1DB3-A nrPDB 265 2e-71 1BXK-A nrPDB 264 3e-71 2Z95-A nrPDB 263 7e-71 2HUN-A nrPDB 262 2e-70 2Q1T-A nrPDB 245 2e-65 1OC2-A nrPDB 242 1e-64 1RPN-A nrPDB 241 3e-64 1ORR-A nrPDB 238 3e-63 2PK3-A nrPDB 235 2e-62 3RUE-A nrPDB 234 4e-62 2PZM-A nrPDB 228 3e-60 2Q1W-A nrPDB 207 6e-54 1GFS-A nrPDB 206 1e-53 3SXP-A nrPDB 201 3e-52 3M2P-A nrPDB 193 1e-49 1WVG-A nrPDB 186 2e-47 4EJ0-A nrPDB 179 2e-45 1RKX-A nrPDB 178 3e-45 4BKP-A nrPDB 172 2e-43 5YWN-A nrPDB 143 2e-34 3WMX-A nrPDB 127 5e-30 2NNL-D nrPDB 115 4e-26 Sequences not found previously or not previously below threshold: 1N7G-A nrPDB 226 7e-60 1EQ2-A nrPDB 141 3e-34 2X86-A nrPDB 140 8e-34 2C54-A nrPDB 140 9e-34 6AQY-A nrPDB 127 5e-30 4WKG-A nrPDB 126 2e-29 5B6K-A nrPDB 119 2e-27 4PVC-A nrPDB 99 2e-21 4R1T-A nrPDB 99 3e-21 3HFS-A nrPDB 98 5e-21 2GN9-A nrPDB 96 2e-20 2P4H-X nrPDB 96 3e-20 4R1U-A nrPDB 92 4e-19 4QUK-A nrPDB 91 9e-19 4G5H-A nrPDB 90 1e-18 4J2O-A nrPDB 87 1e-17 1VL0-A nrPDB 85 4e-17 5U9C-A nrPDB 83 1e-16 3RFT-A nrPDB 81 8e-16 4WPG-A nrPDB 81 8e-16 4KTT-E nrPDB 80 1e-15 3SC6-A nrPDB 79 2e-15 1KC3-A nrPDB 77 1e-14 2GGS-A nrPDB 74 1e-13 1ZZE-A nrPDB 71 8e-13 4QQR-A nrPDB 61 5e-10 3SLK-A nrPDB 61 5e-10 6GCS-E nrPDB 57 1e-08 3PVZ-A nrPDB 56 2e-08 3KZV-A nrPDB 52 3e-07 4AVY-A nrPDB 49 4e-06 3U5T-A nrPDB 48 5e-06 3EZL-A nrPDB 48 5e-06 1QYC-A nrPDB 48 6e-06 1HE4-A nrPDB 48 7e-06 3A28-C nrPDB 47 9e-06 2NM0-A nrPDB 47 1e-05 2QYS-A nrPDB 46 2e-05 2V6G-A nrPDB 46 3e-05 2GDZ-A nrPDB 45 4e-05 1K2W-A nrPDB 45 5e-05 5U9P-A nrPDB 45 5e-05 1QYD-A nrPDB 45 5e-05 3OSU-A nrPDB 45 6e-05 3PXX-A nrPDB 44 8e-05 1GEG-A nrPDB 44 8e-05 3RWB-A nrPDB 44 1e-04 6CGE-A nrPDB 44 1e-04 4KMS-A nrPDB 44 1e-04 1A27-A nrPDB 44 1e-04 6NRP-A nrPDB 43 2e-04 2GAS-A nrPDB 43 2e-04 3VZS-A nrPDB 43 2e-04 6CI9-A nrPDB 43 2e-04 5ITV-A nrPDB 43 2e-04 3WYE-A nrPDB 42 3e-04 5ILO-A nrPDB 42 3e-04 4B4O-A nrPDB 42 3e-04 4K6F-A nrPDB 42 4e-04 3U9L-A nrPDB 42 4e-04 1UZM-A nrPDB 42 4e-04 2Q4B-A nrPDB 41 6e-04 6G2J-P nrPDB 41 7e-04 3RKU-A nrPDB 41 8e-04 2PNF-A nrPDB 41 0.001 5OVL-A nrPDB 41 0.001 1YXM-A nrPDB 41 0.001 4MOW-A nrPDB 40 0.001 2FWM-X nrPDB 40 0.001 5PGZ-A nrPDB 40 0.001 5OVJ-A nrPDB 40 0.002 4IIN-A nrPDB 40 0.002 3OEC-A nrPDB 40 0.002 4DBZ-A nrPDB 40 0.002 4E6P-A nrPDB 40 0.002 4IIV-A nrPDB 39 0.002 4RGB-A nrPDB 39 0.003 3DWF-A nrPDB 39 0.003 5LCX-A nrPDB 39 0.003 3WTC-A nrPDB 39 0.004 3WOH-A nrPDB 39 0.004 5VT6-A nrPDB 39 0.004 5F5N-A nrPDB 39 0.004 2NWQ-A nrPDB 38 0.005 3UN1-A nrPDB 38 0.005 5GUP-L nrPDB 38 0.006 1AE1-A nrPDB 38 0.006 3F9I-A nrPDB 37 0.009 2BC1-A nrPDB 37 0.010 1OOE-A nrPDB 37 0.010 3GRP-A nrPDB 37 0.012 3OIC-A nrPDB 37 0.012 2UVD-A nrPDB 37 0.012 6D9T-A nrPDB 37 0.012 3OML-A nrPDB 37 0.013 3O4R-A nrPDB 37 0.013 3ZV3-A nrPDB 37 0.014 5IZ4-A nrPDB 37 0.014 1BDB-A nrPDB 37 0.016 3RSH-A nrPDB 36 0.018 2HRB-A nrPDB 36 0.020 3O26-A nrPDB 36 0.029 3ORF-A nrPDB 36 0.030 3KYB-A nrPDB 36 0.032 3EMK-A nrPDB 36 0.035 2PH3-A nrPDB 36 0.036 4CQL-A nrPDB 36 0.037 1H5Q-A nrPDB 36 0.037 5CDY-A nrPDB 35 0.041 2Q2Q-A nrPDB 35 0.044 3V8B-A nrPDB 35 0.046 2ZCU-A nrPDB 35 0.054 5YSS-A nrPDB 35 0.056 3D3W-A nrPDB 35 0.063 3MJ4-A nrPDB 35 0.065 1Q7C-A nrPDB 34 0.069 3PPI-A nrPDB 34 0.072 4HP8-A nrPDB 34 0.079 2HSD-A nrPDB 34 0.083 5L51-A nrPDB 34 0.087 5WQO-A nrPDB 34 0.098 5DBI-A nrPDB 34 0.13 2ZAT-A nrPDB 34 0.13 1O89-A nrPDB 34 0.14 4IS3-A nrPDB 34 0.15 5B1Y-A nrPDB 33 0.15 4NBT-A nrPDB 33 0.18 5OKP-A nrPDB 33 0.18 3NR8-B nrPDB 33 0.18 3V2H-A nrPDB 33 0.19 3PWS-A nrPDB 33 0.20 2BKA-A nrPDB 33 0.20 3R3S-A nrPDB 33 0.21 5D01-A nrPDB 33 0.22 1DOH-A nrPDB 33 0.23 3T7C-A nrPDB 33 0.24 3H0K-A nrPDB 32 0.26 5ER0-A nrPDB 32 0.33 3V2G-A nrPDB 32 0.33 2X9N-A nrPDB 32 0.38 4CR6-A nrPDB 32 0.39 4BO1-A nrPDB 32 0.39 1JB1-A nrPDB 32 0.40 2I2W-A nrPDB 32 0.46 3LFL-A nrPDB 32 0.49 1DIR-A nrPDB 32 0.51 4G65-A nrPDB 32 0.52 2G17-A nrPDB 31 0.63 1CYD-A nrPDB 31 0.64 2B4Q-A nrPDB 31 0.73 1HXH-A nrPDB 31 0.77 2LDB-A nrPDB 31 0.78 2AE2-A nrPDB 31 0.80 4GBJ-A nrPDB 31 0.81 2JJM-A nrPDB 31 0.82 1V9L-A nrPDB 31 0.84 4RZH-A nrPDB 31 0.88 3L0D-A nrPDB 31 0.88 3ICS-A nrPDB 31 0.88 4NBV-A nrPDB 31 0.93 5GXF-A nrPDB 31 0.98 2YV2-A nrPDB 31 1.1 5NUE-A nrPDB 31 1.1 4J6F-A nrPDB 31 1.2 3A14-A nrPDB 31 1.2 5I34-A nrPDB 31 1.2 1VIM-A nrPDB 30 1.3 2DKN-A nrPDB 30 1.3 2PV7-A nrPDB 30 1.4 1P33-A nrPDB 30 1.4 4RZI-B nrPDB 30 1.4 3MD0-A nrPDB 30 1.7 4XRR-A nrPDB 30 1.9 1KO7-A nrPDB 30 2.0 2O23-A nrPDB 30 2.0 1NFF-A nrPDB 29 2.3 4UUP-A nrPDB 29 2.4 2TMD-A nrPDB 29 2.5 1JAY-A nrPDB 29 2.8 4UUM-A nrPDB 29 2.8 6NCW-A nrPDB 29 3.3 5ENV-A nrPDB 29 3.4 3I83-A nrPDB 29 3.6 4I1I-A nrPDB 29 3.7 5HKP-A nrPDB 29 4.6 4UUO-A nrPDB 28 5.6 4YD8-A nrPDB 28 6.5 1AHH-A nrPDB 28 7.2 5LZL-A nrPDB 28 7.3 5JHQ-A nrPDB 28 7.6 2R9Z-A nrPDB 27 9.9 5JS6-A nrPDB 27 9.9 >1I3M-A nrPDB Length = 348 Score = 489 bits (1259), Expect = e-139, Method: Composition-based stats. Identities = 346/348 (99%), Positives = 347/348 (99%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV Sbjct: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 Query: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKA+GESVQKPLDYYRVNLTGTIQLLEIMK Sbjct: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAMGESVQKPLDYYRVNLTGTIQLLEIMK 120 Query: 121 AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA 180 AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWN Sbjct: 121 AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNV 180 Query: 181 VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD 240 VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD Sbjct: 181 VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD 240 Query: 241 YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR 300 YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR Sbjct: 241 YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR 300 Query: 301 EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA 348 EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA Sbjct: 301 EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA 348 >1UDA-A nrPDB Length = 338 Score = 411 bits (1055), Expect = e-115, Method: Composition-based stats. Identities = 179/342 (52%), Positives = 235/342 (68%), Gaps = 6/342 (1%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 +VLVTGG+GYIGSHT ++LL+ G+ +++DN N+ R L ++ L G+ F Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKR------SVLPVIERLGGKHPTF 54 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 E DI ++ + + ++ VIHFAGLKAVGESVQKPL+YY N+ GT++L+ M+A Sbjct: 55 VEGDIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAA 114 Query: 123 GVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVL 182 VKN +FSSSATVYG+ +P E+ PTG +PYGKSK +E+++ DL +A W+ L Sbjct: 115 NVKNFIFSSSATVYGDNPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIAL 174 Query: 183 LRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYI 242 LRYFNP GAH SG +GEDPQGIPNNLMPY++QVA+GRR++L +FGNDY TEDGTGVRDYI Sbjct: 175 LRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYI 234 Query: 243 HVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREG 302 HV+DLA GH+ A+ KL + G IYNLG G G SVL +V A KA GK + Y RREG Sbjct: 235 HVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREG 294 Query: 303 DVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGF 344 D+ A +A+ S A EL W LD M +D W WQ ++P G+ Sbjct: 295 DLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGY 336 >1Z45-A nrPDB Length = 699 Score = 391 bits (1003), Expect = e-109, Method: Composition-based stats. Identities = 186/352 (52%), Positives = 243/352 (69%), Gaps = 16/352 (4%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 ++ VLVTGGAGYIGSHTV+EL+E GY VV DN N+ +S+ R++ LT + Sbjct: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNST------YDSVARLEVLTKHHIP 64 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 F E+D+ D+ L+++FK+Y +VIHFAGLKAVGES Q PL YY N+ GT+ LLE+M+ Sbjct: 65 FYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQ 124 Query: 122 HGVKNLVFSSSATVYGN----PQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADK- 176 + V VFSSSATVYG+ P +P+ E P G TNPYG +K+ IE ++ DL +DK Sbjct: 125 YNVSKFVFSSSATVYGDATRFPNMIPIPEECPL-GPTNPYGHTKYAIENILNDLYNSDKK 183 Query: 177 TWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGT 236 +W +LRYFNP GAH SG IGEDP GIPNNL+PY++QVA+GRRE L +FG+DYD+ DGT Sbjct: 184 SWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGT 243 Query: 237 GVRDYIHVVDLAKGHIAALRKL----KEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKI 292 +RDYIHVVDLAKGHIAAL+ L + + CR +NLG+G G +V ++ A KASG + Sbjct: 244 PIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDL 303 Query: 293 PYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGF 344 PYKV RR GDV A P A+ EL W L ++ C+DLW+W +NP G+ Sbjct: 304 PYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGY 355 >3ENK-A nrPDB Length = 341 Score = 386 bits (992), Expect = e-108, Method: Composition-based stats. Identities = 199/346 (57%), Positives = 249/346 (71%), Gaps = 9/346 (2%) Query: 1 MAEK--VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGR 58 M+ K +LVTGGAGYIGSHT +ELL GY V+ DN N+ R E++ R++++TG+ Sbjct: 2 MSTKGTILVTGGAGYIGSHTAVELLAHGYDVVIADNLVNSKR------EAIARIEKITGK 55 Query: 59 SVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEI 118 + F E D+ D+ AL R+F + A IHFA LKAVGESV KP++YYR NL + LL + Sbjct: 56 TPAFHETDVSDERALARIFDAHPITAAIHFAALKAVGESVAKPIEYYRNNLDSLLSLLRV 115 Query: 119 MKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTW 178 M+ VK +VFSSSATVYG P+ P+DE P TNPYG++K E+++RD+ AD +W Sbjct: 116 MRERAVKRIVFSSSATVYGVPERSPIDETFPL-SATNPYGQTKLMAEQILRDVEAADPSW 174 Query: 179 NAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGV 238 LRYFNP GAH SG IGEDP GIPNNLMPYV+QVA+G+ E L VFG+DY T DGTGV Sbjct: 175 RVATLRYFNPVGAHESGLIGEDPAGIPNNLMPYVAQVAVGKLEKLRVFGSDYPTPDGTGV 234 Query: 239 RDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVA 298 RDYIHVVDLA+GHIAAL L+ + NLGTG GYSVL++V+A EKASG+ +PY++VA Sbjct: 235 RDYIHVVDLARGHIAALDALERRDASLTVNLGTGRGYSVLEVVRAFEKASGRAVPYELVA 294 Query: 299 RREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGF 344 RR GDVA CYANP+ A E +GW A L+RMC D WRWQ+ NP GF Sbjct: 295 RRPGDVAECYANPAAAAETIGWKAERDLERMCADHWRWQENNPRGF 340 >4LIS-A nrPDB Length = 371 Score = 386 bits (991), Expect = e-108, Method: Composition-based stats. Identities = 184/365 (50%), Positives = 237/365 (64%), Gaps = 26/365 (7%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 + VLVTGG GYIGS T L LLEAGY VV DN +N+ E+L R++ ++G+ E Sbjct: 3 SGSVLVTGGTGYIGSFTTLALLEAGYKVVVADNLYNSS------AEALNRIELISGKKAE 56 Query: 62 FEEMDILDQGALQRLFKKY-SFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 F ++D+ D+ A ++F+ + +VIHFA LKAVGES +KPLDYY VN+ GTI LL M Sbjct: 57 FAQLDVTDEAAFDKVFEAHPDIDSVIHFAALKAVGESGEKPLDYYHVNVYGTICLLRSMV 116 Query: 121 AHGVKNLVFSSSATVYGN----PQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADK 176 H V N+VFSSSATVYG+ P +P+ E P G TNPYG +KF IE I D+ A + Sbjct: 117 RHNVTNIVFSSSATVYGDATRFPDMIPIPEHCPL-GPTNPYGNTKFAIELAITDVINAQR 175 Query: 177 T-------------WNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREAL 223 WN LLRYFNP GAH SG +GEDPQG+P NL+P ++QVA G+RE L Sbjct: 176 NNAKKAGNETEAAKWNGALLRYFNPAGAHPSGIMGEDPQGVPYNLLPLLAQVATGKREKL 235 Query: 224 NVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLK-EQCGCRIYNLGTGTGYSVLQMVQ 282 VFG+DY + DGT +RDYIH++DLA GH+ AL L+ G R +NLGTG G +V +M++ Sbjct: 236 LVFGDDYASHDGTAIRDYIHILDLADGHLKALNYLRANNPGVRAWNLGTGRGSTVYEMIR 295 Query: 283 AMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPS 342 A KA G+ +PY+V RR GDV +NP+ A ELGW A L++ CEDLW W K NP Sbjct: 296 AFSKAVGRDLPYEVAPRRAGDVLNLTSNPTRANTELGWKAQRTLEQACEDLWLWTKNNPQ 355 Query: 343 GFGTQ 347 G+ Q Sbjct: 356 GYRQQ 360 >2C20-A nrPDB Length = 330 Score = 339 bits (868), Expect = 1e-93, Method: Composition-based stats. Identities = 128/343 (37%), Positives = 187/343 (54%), Gaps = 17/343 (4%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 +L+ GGAGYIGSH V +L++ G VV+DN ++ +F Sbjct: 2 NSILICGGAGYIGSHAVKKLVDEGLSVVVVDNLQTGH-------------EDAITEGAKF 48 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 D+ D+ L+ +F + + AV+HFA VG S++KPL YY N+ G + LLE+M Sbjct: 49 YNGDLRDKAFLRDVFTQENIEAVMHFAADSLVGVSMEKPLQYYNNNVYGALCLLEVMDEF 108 Query: 123 GVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVL 182 V +FSS+A YG + E T TN YG++K IE+M+ QA + Sbjct: 109 KVDKFIFSSTAATYGEVDVDLITEETMT-NPTNTYGETKLAIEKMLHWYSQASN-LRYKI 166 Query: 183 LRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYI 242 RYFN GA +G IGED + +L+P V QVA+G+RE + +FG+DY+T DGT +RDYI Sbjct: 167 FRYFNVAGATPNGIIGEDHRPET-HLIPLVLQVALGQREKIMMFGDDYNTPDGTCIRDYI 225 Query: 243 HVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREG 302 HV DL H L+ L+ YNLG G G+SV ++V A+ + + +IP +V RR G Sbjct: 226 HVEDLVAAHFLGLKDLQNGGESDFYNLGNGNGFSVKEIVDAVREVTNHEIPAEVAPRRAG 285 Query: 303 DVAACYANPSLAQEELGWTAAL-GLDRMCEDLWRWQKQNPSGF 344 D A A+ A+E+LGW + + E W W ++ P+G+ Sbjct: 286 DPARLVASSQKAKEKLGWDPRYVNVKTIIEHAWNWHQKQPNGY 328 >1GY8-A nrPDB Length = 397 Score = 329 bits (842), Expect = 2e-90, Method: Composition-based stats. Identities = 137/384 (35%), Positives = 193/384 (50%), Gaps = 40/384 (10%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPES----LRRVQELTGR 58 +VLV GGAGYIGSH V LL VVI + G E+ R++Q+ G Sbjct: 3 MRVLVCGGAGYIGSHFVRALLRDTNHSVVIVDSLVGTHGKSDHVETRENVARKLQQSDGP 62 Query: 59 S-------VEFEEMDILDQGALQRLFKKYSF-MAVIHFAGLKAVGESVQKPLDYYRVNLT 110 E D+ ++ L +F ++ AV+H AVGESV+ PL YY N+ Sbjct: 63 KPPWADRYAALEVGDVRNEDFLNGVFTRHGPIDAVVHMCAFLAVGESVRDPLKYYDNNVV 122 Query: 111 GTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEA------HPTGGCTNPYGKSKFFI 164 G ++LL+ M H ++FSSSA ++GNP + + +PYG+SK Sbjct: 123 GILRLLQAMLLHKCDKIIFSSSAAIFGNPTMGSVSTNAEPIDINAKKSPESPYGESKLIA 182 Query: 165 EEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQG----IPNNLMPYVSQVAIGRR 220 E MIRD +A + LRYFN GAH G IGE QG IP L +S +A +R Sbjct: 183 ERMIRDCAEAY-GIKGICLRYFNACGAHEDGDIGEHYQGSTHLIPIILGRVMSDIAPDQR 241 Query: 221 ----------EALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCR----- 265 + + +FG DY T DGT VRDY+HV DLA HI AL +++ Sbjct: 242 LTIHEDASTDKRMPIFGTDYPTPDGTCVRDYVHVCDLASAHILALDYVEKLGPNDKSKYF 301 Query: 266 -IYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAAL 324 ++NLGT GYSV ++++ K +G IP + RREGD A A A+E LGW Sbjct: 302 SVFNLGTSRGYSVREVIEVARKTTGHPIPVRECGRREGDPAYLVAASDKAREVLGWKPKY 361 Query: 325 -GLDRMCEDLWRWQKQNPSGFGTQ 347 L+ + E W++Q+ +P+G+ +Q Sbjct: 362 DTLEAIMETSWKFQRTHPNGYASQ 385 >4WOK-A nrPDB Length = 336 Score = 319 bits (818), Expect = 8e-88, Method: Composition-based stats. Identities = 137/332 (41%), Positives = 180/332 (54%), Gaps = 17/332 (5%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 A VLV GGAG+IGSHT L GY PVV DN + R + Sbjct: 11 ANNVLVVGGAGFIGSHTAKLLAGQGYAPVVYDNLSTGHQSAV--------------RWGD 56 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 F E DILDQ L +KY+ +AVIHFA VGESV+ P YYR N+ GT LL+ + Sbjct: 57 FVEGDILDQARLVETMEKYAPVAVIHFAASAYVGESVEDPAKYYRNNVGGTQSLLDACRL 116 Query: 122 HGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAV 181 +N++FSSS YG P LP+ E NPYG++K E M+ D A V Sbjct: 117 TRTQNVIFSSSCATYGVPSRLPIGEGEA-QNPINPYGRTKLIAEHMLADYAVAY-GLRYV 174 Query: 182 LLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDY 241 LRYFN +GA G +GE +L+P A GR + L V+G+DY+T DGT +RDY Sbjct: 175 ALRYFNASGADIDGELGEKHDPET-HLIPRAMMAAAGRLDVLEVYGDDYETPDGTCIRDY 233 Query: 242 IHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARRE 301 IHV DLA+ H+ A+ LKE G NLGTG G S+ ++VQ++ + +G+ +P + ARR Sbjct: 234 IHVTDLARAHVLAVEHLKEAGGNLAVNLGTGRGTSIREIVQSIGRLTGRSVPVAMRARRA 293 Query: 302 GDVAACYANPSLAQEELGWTAALGLDRMCEDL 333 GD A YA+P+LA E+LG+ Sbjct: 294 GDPPALYADPALAAEKLGFHTVYSDLDTIIRT 325 >5UZH-A nrPDB Length = 345 Score = 285 bits (728), Expect = 3e-77, Method: Composition-based stats. Identities = 79/360 (21%), Positives = 146/360 (40%), Gaps = 49/360 (13%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 ++ L+TG G GS+ LLE GY+ I ++F G E L + +T + Sbjct: 1 SKVALITGITGQDGSYLAEFLLEKGYMVYGIIRRSSSFNTG--RVEHLYKDIHITKAKFK 58 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 D+ D G L + K + + A V S + P V+ GT++LLE ++A Sbjct: 59 LLYGDLTDTGNLISIIAKIKPDEIYNLAAQSHVKVSFEMPEYTANVDGIGTLRLLEAIRA 118 Query: 122 HGVK---NLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTW 178 G++ +S++ +YG Q +P E P +PY +K + ++ + +A + Sbjct: 119 CGLEKKTKFYQASTSELYGLVQEVPQKETTPFY-PRSPYACAKLYSYWIVVNYREAYNMF 177 Query: 179 --NAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGT 236 N +L H S I P + + V+++ +G ++ L + D Sbjct: 178 ALNGILFN-------HES--IRRGPTFVTRKITMAVARIKLGLQDCLYLGNLD------- 221 Query: 237 GVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYK- 295 RD+ H D ++ A+ + +Q R + + TG +SV + V+ G+ + +K Sbjct: 222 AERDWGHAKD----YVEAMWLMLQQEQPRDFCVATGEKHSVREFVEKAFACIGQTVEWKG 277 Query: 296 ------------------VVAR--REGDVAACYANPSLAQEELGWTAALGLDRMCEDLWR 335 V R R +V +P+LA+ LGW + + + + Sbjct: 278 ERGTVEEHGVVDGVVRVRVDPRYFRPTEVDQLLGDPTLAETVLGWKRKVSFEELVRGMVE 337 >6GPK-A nrPDB Length = 373 Score = 273 bits (698), Expect = 8e-74, Method: Composition-based stats. Identities = 72/372 (19%), Positives = 143/372 (38%), Gaps = 52/372 (13%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M L+TG G GS+ LLE GY I ++F G + + Q ++ Sbjct: 23 MRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNT-GRIEHLYKNPQAHIEGNM 81 Query: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 + D+ D L ++ + + + V S V+ GT++LL+ +K Sbjct: 82 KLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVK 141 Query: 121 AHGVKNLV---FSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKT 177 G+ N V +S++ +YG Q +P E P +PYG +K + ++ + +A Sbjct: 142 TCGLINSVKFYQASTSQLYGKVQEIPQKETTPFY-PRSPYGAAKLYAYWIVVNFREAYNL 200 Query: 178 W--NAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDG 235 + N +L + +P + + V+++ +G+ E ++ D Sbjct: 201 FAVNGILFNHESP---------RRGANFVTRKISRSVAKIYLGQLECFSLGNLD------ 245 Query: 236 TGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYK 295 RD+ H D ++ A+ + + + + TG +SV + V+ GK I ++ Sbjct: 246 -AKRDWGHAKD----YVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWE 300 Query: 296 -----VVAR----------------REGDVAACYANPSLAQEELGWTAALGLDRMCEDLW 334 V R R +V + + A+++L W + D + ++ Sbjct: 301 GKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMV 360 Query: 335 RW----QKQNPS 342 + NP+ Sbjct: 361 HADVELMRTNPN 372 >6BI4-A nrPDB Length = 346 Score = 272 bits (696), Expect = 1e-73, Method: Composition-based stats. Identities = 82/340 (24%), Positives = 149/340 (43%), Gaps = 27/340 (7%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 A +LVTGGAG+IGS+ V +L++ Y I NF +A G+L +++ +Q+ + Sbjct: 24 AMNILVTGGAGFIGSNFVHYMLQS-YETYKIINF-DALTYSGNL-NNVKSIQD--HPNYY 78 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 F + +I + L+ + K+ +++FA V S++ P+ +Y N+ GT+ LLE++K Sbjct: 79 FVKGEIQNGELLEHVIKERDVQVIVNFAAESHVDRSIENPIPFYDTNVIGTVTLLELVKK 138 Query: 122 HGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAV 181 + LV S+ VYG+ +PY SK + + + + + Sbjct: 139 YPHIKLVQVSTDEVYGSLGKTGRFTEETPLAPNSPYSSSKASADMIALAYYKTYQ-LPVI 197 Query: 182 LLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDY 241 + R N G P P L+P + A+ + L ++G DG VRD+ Sbjct: 198 VTRCSNNYG----------PYQYPEKLIPLMVTNALEGK-KLPLYG------DGLNVRDW 240 Query: 242 IHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGK-KIPYKVVARR 300 +HV D L + +YN+G + +++V+ + GK K + V R Sbjct: 241 LHVTDHCSA---IDVVLHKGRVGEVYNIGGNNEKTNVEVVEQIITLLGKTKKDIEYVTDR 297 Query: 301 EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQN 340 G N + E W ++ ++ +W ++N Sbjct: 298 LGHDRRYAINAEKMKNEFDWEPKYTFEQGLQETVQWYEKN 337 >1KEU-A nrPDB Length = 361 Score = 272 bits (694), Expect = 2e-73, Method: Composition-based stats. Identities = 84/368 (22%), Positives = 135/368 (36%), Gaps = 57/368 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVV-IDNFHNAFRGGGSLPESLRRVQELTG-RSV 60 K+L+TGGAG+IGS V +++ VV ID A +L + +++ Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQDTVVNIDKLTYA--------GNLESLSDISESNRY 52 Query: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 FE DI D + R+F++Y AV+H A V S+ P + N+ GT LLE+ + Sbjct: 53 NFEHADICDSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYALLEVAR 112 Query: 121 AHGVK---------NLVFSSSATVYGNPQ---------YLPLDEAHPTGGCTNPYGKSKF 162 + S+ VYG+ LPL ++PY SK Sbjct: 113 KYWSALGEDKKNNFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKA 172 Query: 163 FIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREA 222 + ++R + ++ N G P P L+P V A+ + Sbjct: 173 SSDHLVRAWRRTY-GLPTIVTNCSNNYG----------PYHFPEKLIPLVILNALEGK-P 220 Query: 223 LNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMV- 281 L ++G G +RD+++V D A+ + E YN+G L +V Sbjct: 221 LPIYGK------GDQIRDWLYVEDHARAL---HMVVTEGKAGETYNIGGHNEKKNLDVVF 271 Query: 282 -------QAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLW 334 + + KA+ + VA R G + ELGW + Sbjct: 272 TICDLLDEIVPKATSYREQITYVADRPGHDRRYAIDAGKISRELGWKPLETFESGIRKTV 331 Query: 335 RWQKQNPS 342 W N Sbjct: 332 EWYLANTQ 339 >1R66-A nrPDB Length = 337 Score = 267 bits (681), Expect = 6e-72, Method: Composition-based stats. Identities = 83/345 (24%), Positives = 130/345 (37%), Gaps = 38/345 (11%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGY------LPVVIDNFHNAFRGGGSLPESLRRVQELT 56 ++LVTGGAG+IGSH V +LL Y +V+D+ A P Sbjct: 1 MRLLVTGGAGFIGSHFVRQLLAGAYPDVPADEVIVLDSLTYAGNRANLAPVDA------- 53 Query: 57 GRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLL 116 + F DI D G L R + A++HFA V S+ + N+ GT LL Sbjct: 54 DPRLRFVHGDIRDAGLLARELRGV--DAIVHFAAESHVDRSIAGASVFTETNVQGTQTLL 111 Query: 117 EIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADK 176 + GV +V S+ VYG+ E+ P +PY SK + + R Sbjct: 112 QCAVDAGVGRVVHVSTDEVYGSIDSGSWTESSPLE-PNSPYAASKAGSDLVARAY-HRTY 169 Query: 177 TWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGT 236 + + R N G P P L+P + L ++G DG Sbjct: 170 GLDVRITRCCNNYG----------PYQHPEKLIPLFVTNLLDG-GTLPLYG------DGA 212 Query: 237 GVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKI-PYK 295 VR+++H D +G L IY++G G + ++ + + G + Sbjct: 213 NVREWVHTDDHCRGIALVL---AGGRAGEIYHIGGGLELTNRELTGILLDSLGADWSSVR 269 Query: 296 VVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQN 340 VA R+G + + ELG+ + RW ++N Sbjct: 270 KVADRKGHDLRYSLDGGKIERELGYRPQVSFADGLARTVRWYREN 314 >6BWL-A nrPDB Length = 328 Score = 266 bits (680), Expect = 8e-72, Method: Composition-based stats. Identities = 90/347 (25%), Positives = 139/347 (40%), Gaps = 37/347 (10%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 K+LVTGGAG+IG V LL+ + ++DN N+ + +++ Sbjct: 1 MKILVTGGAGFIGRWVVKRLLQDKHEVWILDNLANSTTANITEFAHDLNLKQ-------C 53 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 + DI D+ + +LF+ SF H A V +S+ + + GT LLE + Sbjct: 54 IQGDIKDKKLVAQLFENNSFDLCYHLAASINVQDSIDDARATFENDTIGTFNLLEQCLNY 113 Query: 123 GVKNLVFSSSATVYGNPQYLP-LDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAV 181 V +VF S+ VY + + E P +PY SK E M+ A K V Sbjct: 114 DV-KMVFMSTCMVYDKATNIQGISELDPIKPA-SPYAGSKIAAENMVLSYYYAYK-LPVV 170 Query: 182 LLRYFNPTGAHA-SGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD 240 ++R FN G +G G NN + V LN++G DG RD Sbjct: 171 VIRPFNTYGPFQKTGGEGGVVAIFINNKLDNV---------PLNIYG------DGKQTRD 215 Query: 241 YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVA-- 298 ++V D A +AA K I N GTG S+ ++ + + SG K+ + V Sbjct: 216 LLYVEDCADFVVAAGYSAK--ANGHIINAGTGQDISINKLAELI---SGNKVSIQHVTHI 270 Query: 299 RREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQ---NPS 342 + ++ N A+ L W + L+ W K NP Sbjct: 271 HPQSEIQKLLCNYEKAKTILNWEPKVSLEDGVIKTEEWIKSLKINPK 317 >1DB3-A nrPDB Length = 372 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 74/369 (20%), Positives = 133/369 (36%), Gaps = 59/369 (15%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 ++ L+TG G GS+ LLE GY I ++F + + + Sbjct: 1 SKVALITGVTGQDGSYLAEFLLEKGYEVHGIKRRASSFNT--ERVDHIYQDPHTCNPKFH 58 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 D+ D L R+ ++ V + + V S + P V+ GT++LLE ++ Sbjct: 59 LHYGDLSDTSNLTRILREVQPDEVYNLGAMSHVAVSFESPEYTADVDAMGTLRLLEAIRF 118 Query: 122 HGVK---NLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTW 178 G++ +S++ +YG Q +P E P +PY +K + + + ++ + Sbjct: 119 LGLEKKTRFYQASTSELYGLVQEIPQKETTPFY-PRSPYAVAKLYAYWITVNYRESYGMY 177 Query: 179 --NAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGT 236 N +L H S GE + + ++ +A G L + D Sbjct: 178 ACNGILFN-------HESPRRGE--TFVTRKITRAIANIAQGLESCLYLGNMDS------ 222 Query: 237 GVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKV 296 +RD+ H D K L +Q + + TG YSV Q V+ G K+ ++ Sbjct: 223 -LRDWGHAKDYVKMQWMML----QQEQPEDFVIATGVQYSVRQFVEMAAAQLGIKLRFEG 277 Query: 297 VAR-------------------------------REGDVAACYANPSLAQEELGWTAALG 325 R +V +P+ A E+LGW + Sbjct: 278 TGVEEKGIVVSVTGHDAPGVKPGDVIIAVDPRYFRPAEVETLLGDPTKAHEKLGWKPEIT 337 Query: 326 LDRMCEDLW 334 L M ++ Sbjct: 338 LREMVSEMV 346 >1BXK-A nrPDB Length = 355 Score = 264 bits (675), Expect = 3e-71, Method: Composition-based stats. Identities = 82/368 (22%), Positives = 131/368 (35%), Gaps = 53/368 (14%) Query: 3 EKVLVTGGAGYIGSHTVLELL-EAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 K+L+TGGAG+IGS V ++ E VV+D A P + Sbjct: 2 RKILITGGAGFIGSALVRYIINETSDAVVVVDKLTYAGNLMSLAPVA-------QSERFA 54 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 FE++DI D+ L R+F ++ V+H A V S+ P + N+ GT LLE +A Sbjct: 55 FEKVDICDRAELARVFTEHQPDCVMHLAAESHVDRSIDGPAAFIETNIVGTYTLLEAARA 114 Query: 122 HG---------VKNLVFSSSATVYGNPQYLP--LDEAHPTGGCTNPYGKSKFFIEEMIRD 170 + S+ VYG+ E P ++PY SK + ++R Sbjct: 115 YWNALTEDKKSAFRFHHISTDEVYGDLHSTDDFFTETTP-YAPSSPYSASKASSDHLVRA 173 Query: 171 LCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDY 230 + ++ N G P P L+P + A+ + L V+GN Sbjct: 174 WLRTY-GLPTLITNCSNNYG----------PYHFPEKLIPLMILNALAGKS-LPVYGN-- 219 Query: 231 DTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASG- 289 G +RD+++V D A+ YN+G L +V+ + + Sbjct: 220 ----GQQIRDWLYVEDHARALYCV---ATTGKVGETYNIGGHNERKNLDVVETICELLEE 272 Query: 290 -----------KKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQK 338 + VA R G + S ELG + +W Sbjct: 273 LAPNKPHGVAHYRDLITFVADRPGHDLRYAIDASKIARELGCVPQETFESGMRKTVQWYL 332 Query: 339 QNPSGFGT 346 N S + Sbjct: 333 ANESWWKQ 340 >2Z95-A nrPDB Length = 345 Score = 263 bits (673), Expect = 7e-71, Method: Composition-based stats. Identities = 74/356 (20%), Positives = 142/356 (39%), Gaps = 50/356 (14%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQEL-TGRSVE 61 ++ L+TG G G++ LLE GY D F + R++EL V+ Sbjct: 4 KRALITGIRGQDGAYLAKLLLEKGYEVYGADRRSGEF--------ASWRLKELGIENDVK 55 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 MD+L+ + R +K V + A VG S ++P+ V+ G +++LE ++ Sbjct: 56 IIHMDLLEFSNIIRTIEKVQPDEVYNLAAQSFVGVSFEQPILTAEVDAIGVLRILEALRT 115 Query: 122 HGVKNLVF-SSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA 180 + +S++ ++G Q +P E P +PY +K F + + +A + Sbjct: 116 VKPDTKFYQASTSEMFGKVQEIPQTEKTPFY-PRSPYAVAKLFGHWITVNYREAYNMFAC 174 Query: 181 VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD 240 + FN H S G + + + ++++ G ++ L + + RD Sbjct: 175 SGI-LFN----HESPLRG--IEFVTRKITYSLARIKYGLQDKLVL-------GNLNAKRD 220 Query: 241 YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPY------ 294 + + A ++ A+ + +Q Y + TG ++V + V+ K +G I + Sbjct: 221 WGY----APEYVEAMWLMMQQPEPDDYVIATGETHTVREFVEKAAKIAGFDIEWVGEGIN 276 Query: 295 ---------KVVAR------REGDVAACYANPSLAQEELGWTAALGLDRMCEDLWR 335 KV+ R +V NP A ++LGW D + E + Sbjct: 277 EKGIDRNTGKVIVEVSEEFFRPAEVDILVGNPEKAMKKLGWKPRTTFDELVEIMME 332 >2HUN-A nrPDB Length = 336 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 81/345 (23%), Positives = 145/345 (42%), Gaps = 39/345 (11%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAG--YLPVVIDNFHNAFRGGGSLPESLRRVQELTGRS 59 + K+LVTGG G+IGS+ + +LE + + ID G GS P +L+ +++ Sbjct: 3 SMKLLVTGGMGFIGSNFIRYILEKHPDWEVINIDKL-----GYGSNPANLKDLED--DPR 55 Query: 60 VEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIM 119 F + D+ D ++ L +K V+H A V S+ P + N+ GT LLE + Sbjct: 56 YTFVKGDVADYELVKELVRKV--DGVVHLAAESHVDRSISSPEIFLHSNVIGTYTLLESI 113 Query: 120 KAHGVK-NLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTW 178 + + V S+ VYG+ E ++PY +K + ++ + Sbjct: 114 RRENPEVRFVHVSTDEVYGDILKGSFTENDRLM-PSSPYSATKAASDMLVLGWTRTYN-L 171 Query: 179 NAVLLRYFNPTGAHASGCIGEDPQGIPNNLMP-YVSQVAIGRREALNVFGNDYDTEDGTG 237 NA + R N G P P L+P + + ++G + + ++G G Sbjct: 172 NASITRCTNNYG----------PYQFPEKLIPKTIIRASLGLK--IPIYGT------GKN 213 Query: 238 VRDYIHVVDLAKGHIAALRKLKEQCGCR-IYNLGTGTGYSVLQMVQAMEKASGKKIP-YK 295 VRD+++V D H+ A+ + + R IYN+ G + L++V+ + + GK + Sbjct: 214 VRDWLYVED----HVRAIELVLLKGESREIYNISAGEEKTNLEVVKIILRLMGKGEELIE 269 Query: 296 VVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQN 340 +V R G + +L W D + W +N Sbjct: 270 LVEDRPGHDLRYSLDSWKITRDLKWRPKYTFDEGIKKTIDWYLKN 314 >2Q1T-A nrPDB Length = 377 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 81/349 (23%), Positives = 135/349 (38%), Gaps = 35/349 (10%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAG-YLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 V+V GGAG++GS+ V LLE G V+DN +A ++ +V Sbjct: 33 TNVMVVGGAGFVGSNLVKRLLELGVNQVHVVDNLLSA-----------EKINVPDHPAVR 81 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 F E I D L L +Y V H A S+ PL + N T++L E +K Sbjct: 82 FSETSITDDALLASLQDEY--DYVFHLATYHGNQSSIHDPLADHENNTLTTLKLYERLKH 139 Query: 122 HG-VKNLVFSSSAT-----VYGNPQYLPLDEAHPTGGCTNPYGKSKFFIE--EMIRDLCQ 173 +K +V+S++ + + + + +PY SK F E + Sbjct: 140 FKRLKKVVYSAAGCSIAEKTFDDAKATEETDIVSLHNNDSPYSMSKIFGEFYSVYYHKQH 199 Query: 174 ADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMP-YVSQVAIGRREALNVFGNDYDT 232 T A + P +G P + N+ P ++ + G L Sbjct: 200 QLPTVRARFQNVYGPGEILGAGRWRGTPATVWRNVTPTFIYKALKGMPLPLE-------- 251 Query: 233 EDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKI 292 G RD+I V D+A G IA + +YN+ +G S+ + + + +G Sbjct: 252 NGGVATRDFIFVEDVANGLIAC---AADGTPGGVYNIASGKETSIADLATKINEITGNNT 308 Query: 293 PYKVVARREGDVAAC-YANPSLAQEELGWTAALGLDRMCEDLWRWQKQN 340 + +R D + + +P A+ ELG++A + +D W K N Sbjct: 309 ELDRLPKRPWDNSGKRFGSPEKARRELGFSADVSIDDGLRKTIEWTKAN 357 >1OC2-A nrPDB Length = 348 Score = 242 bits (618), Expect = 1e-64, Method: Composition-based stats. Identities = 81/361 (22%), Positives = 135/361 (37%), Gaps = 49/361 (13%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + ++VTGGAG+IGS+ V Y+ + H + + ++ + G VE Sbjct: 5 KNIIVTGGAGFIGSNFVH------YVYNNHPDVHVTVLDKLTYAGNKANLEAILGDRVEL 58 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 DI D + +L K A++H+A S+ P + N GT LLE + + Sbjct: 59 VVGDIADAELVDKLAAKA--DAIVHYAAESHNDNSLNDPSPFIHTNFIGTYTLLEAARKY 116 Query: 123 GVKNLVFSSSATVYGNPQYLPLDEAHPTGG--------------CTNPYGKSKFFIEEMI 168 + S+ VYG+ LPL E P G ++PY +K + ++ Sbjct: 117 DI-RFHHVSTDEVYGD---LPLREDLPGHGEGPGEKFTAETNYNPSSPYSSTKAASDLIV 172 Query: 169 RDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMP-YVSQVAIGRREALNVFG 227 + +R F ++ P +P ++ + G + L Sbjct: 173 KAW-----------VRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILAGIKPKL---- 217 Query: 228 NDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKA 287 +G VRD+IH D + G A L K + I G VL+++ +EK Sbjct: 218 ----YGEGKNVRDWIHTNDHSTGVWAILTKGRMGETYLIGADGEKNNKEVLELI--LEKM 271 Query: 288 SGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALG-LDRMCEDLWRWQKQNPSGFGT 346 K Y V R G + S ++ELGWT E+ +W N + Sbjct: 272 GQPKDAYDHVTDRAGHDLRYAIDASKLRDELGWTPQFTDFSEGLEETIQWYTDNQDWWKA 331 Query: 347 Q 347 + Sbjct: 332 E 332 >1RPN-A nrPDB Length = 335 Score = 241 bits (615), Expect = 3e-64, Method: Composition-based stats. Identities = 76/343 (22%), Positives = 140/343 (40%), Gaps = 37/343 (10%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQEL-TGRS 59 M LVTG G G++ LLE GY + ++ ++ R++EL Sbjct: 13 MTRSALVTGITGQDGAYLAKLLLEKGYRVHGLVARRSS--------DTRWRLRELGIEGD 64 Query: 60 VEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIM 119 +++E+ D+ D ++QR K V + A VG S +P+ V+ G LLE + Sbjct: 65 IQYEDGDMADACSVQRAVIKAQPQEVYNLAAQSFVGASWNQPVTTGVVDGLGVTHLLEAI 124 Query: 120 KAHGVKNLVF-SSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTW 178 + + + +S++ ++G Q DE P +PYG +K + + + ++ Sbjct: 125 RQFSPETRFYQASTSEMFGLIQAERQDENTPFY-PRSPYGVAKLYGHWITVNYRES-FGL 182 Query: 179 NAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGV 238 +A FN H S G + + + V+++ +G+++ L + D Sbjct: 183 HASSGILFN----HESPLRG--IEFVTRKVTDAVARIKLGKQQELRLGNVD-------AK 229 Query: 239 RDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVA 298 RD+ D ++ A+ + +Q Y + TG +V M Q + G + Y+ Sbjct: 230 RDWGFAGD----YVEAMWLMLQQDKADDYVVATGVTTTVRDMCQIAFEHVG--LDYRDFL 283 Query: 299 R------REGDVAACYANPSLAQEELGWTAALGLDRMCEDLWR 335 + R +V NP+ AQ LGW LD + + Sbjct: 284 KIDPAFFRPAEVDVLLGNPAKAQRVLGWKPRTSLDELIRMMVE 326 >1ORR-A nrPDB Length = 347 Score = 238 bits (606), Expect = 3e-63, Method: Composition-based stats. Identities = 78/352 (22%), Positives = 142/352 (40%), Gaps = 36/352 (10%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 K+L+TGG G++GS+ L G +V DN ++L + L + EF Sbjct: 3 KLLITGGCGFLGSNLASFALSQGIDLIVFDNLSRKGAT-----DNLHWLSSL--GNFEFV 55 Query: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHG 123 DI ++ + RL KY + H AG A+ S+ P + +N+ GT+ LLE ++ + Sbjct: 56 HGDIRNKNDVTRLITKYMPDSCFHLAGQVAMTTSIDNPCMDFEINVGGTLNLLEAVRQYN 115 Query: 124 VK-NLVFSSSATVYGNPQYLPLDEAHPTGGCT---------------NPYGKSKFFIEEM 167 N+++SS+ VYG+ + +E C +PYG SK ++ Sbjct: 116 SNCNIIYSSTNKVYGDLEQYKYNETETRYTCVDKPNGYDESTQLDFHSPYGCSKGAADQY 175 Query: 168 IRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFG 227 + D + N V+ R+ + G QG ++ G + + G Sbjct: 176 MLDYARI-FGLNTVVFRHSSMYGGRQ---FATYDQGWVGWFCQKAVEIKNGINKPFTISG 231 Query: 228 NDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTG--TGYSVLQMVQAME 285 N G VRD +H D+ + AL + + G +N+G S+L++ + +E Sbjct: 232 N------GKQVRDVLHAEDMISLYFTALANVSKIRG-NAFNIGGTIVNSLSLLELFKLLE 284 Query: 286 KASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQ 337 + + + RE D A+ + W+ + + ++ W Sbjct: 285 DYCNIDMRFTNLPVRESDQRVFVADIKKITNAIDWSPKVSAKDGVQKMYDWT 336 >2PK3-A nrPDB Length = 321 Score = 235 bits (599), Expect = 2e-62, Method: Composition-based stats. Identities = 62/343 (18%), Positives = 135/343 (39%), Gaps = 39/343 (11%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 + + L+TG AG++G + L E F + LP +VE Sbjct: 12 SMRALITGVAGFVGKYLANHLTEQNVEV-----FGTSRNNEAKLP------------NVE 54 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 +DI+D ++++ + H A +V +S + N+ GT+ +L+ ++ Sbjct: 55 MISLDIMDSQRVKKVISDIKPDYIFHLAAKSSVKDSWLNKKGTFSTNVFGTLHVLDAVRD 114 Query: 122 HGVKNLVFS-SSATVYGN--PQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTW 178 + + + S+ YG P+ P+ E + +PYG SK + + R +A Sbjct: 115 SNLDCRILTIGSSEEYGMILPEESPVSEENQLR-PMSPYGVSKASVGMLARQYVKAY-GM 172 Query: 179 NAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGV 238 + + R FN G G+ + + + + + ++E + GN V Sbjct: 173 DIIHTRTFNHIGP------GQSLGFVTQDFAKQIVDIEMEKQEPIIKVGN------LEAV 220 Query: 239 RDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKV-- 296 RD+ V D+ + + + +YN+ +G G + ++ + + KI ++ Sbjct: 221 RDFTDVRDIVQAYWLLSQY---GKTGDVYNVCSGIGTRIQDVLDLLLAMANVKIDTELNP 277 Query: 297 VARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQ 339 + R +V + ++ GW + L++ ++ + +Q Sbjct: 278 LQLRPSEVPTLIGSNKRLKDSTGWKPRIPLEKSLFEILQSYRQ 320 >3RUE-A nrPDB Length = 351 Score = 234 bits (597), Expect = 4e-62, Method: Composition-based stats. Identities = 78/338 (23%), Positives = 148/338 (43%), Gaps = 27/338 (7%) Query: 6 LVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEM 65 L+TG AG+IGS+ + +LL+ + + +DNF + ++L ++ + F E Sbjct: 29 LITGVAGFIGSNLLEKLLKLNQVVIGLDNFSTGHQYNLDEVKTLVSTEQWS--RFCFIEG 86 Query: 66 DILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVK 125 DI D +++ K V+H A L +V S+ P+ N+TG + +L K V+ Sbjct: 87 DIRDLTTCEQVMKGV--DHVLHQAALGSVPRSIVDPITTNATNITGFLNILHAAKNAQVQ 144 Query: 126 NLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRY 185 + +++S++ YG+ LP E + G +PY +K ++ E+ + + + LRY Sbjct: 145 SFTYAASSSTYGDHPALPKVEEN-IGNPLSPYAVTK-YVNEIYAQVYARTYGFKTIGLRY 202 Query: 186 FNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGND-YDTEDGTGVRDYIHV 244 FN G +DP G ++P + A + G+D Y DG RD+ ++ Sbjct: 203 FNVFGRR------QDPNGAYAAVIP--------KWTAAMLKGDDVYINGDGETSRDFCYI 248 Query: 245 VDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASG-----KKIPYKVVAR 299 ++ + +I + K+ IYN+ G ++ ++ + K+ K Sbjct: 249 DNVIQMNILS-ALAKDSAKDNIYNVAVGDRTTLNELSGYIYDELNLIHHIDKLSIKYREF 307 Query: 300 REGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQ 337 R GDV A+ + A + L + + + W Sbjct: 308 RSGDVRHSQADVTKAIDLLKYRPNIKIREGLRLSMPWY 345 >2PZM-A nrPDB Length = 330 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 89/342 (26%), Positives = 138/342 (40%), Gaps = 52/342 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 ++L+TGGAG +GS+ + L G+ +VIDNF R E L V L Sbjct: 21 MRILITGGAGCLGSNLIEHWLPQGHEILVIDNFATGKR------EVLPPVAGL-----SV 69 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYR---VNLTGTIQLLEIM 119 E + D G L+R F + V+H A + + P D+ N+ G+I + + Sbjct: 70 IEGSVTDAGLLERAFDSFKPTHVVHSAA------AYKDPDDWAEDAATNVQGSINVAKAA 123 Query: 120 KAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWN 179 GVK L+ +A YG P +P+ PT T+ YG SK E + Sbjct: 124 SKAGVKRLLNFQTALCYGRPATVPIPIDSPTAPFTS-YGISKTAGEAFLM-----MSDVP 177 Query: 180 AVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVR 239 V LR N TG + IG P ++ G++ F +D VR Sbjct: 178 VVSLRLANVTGPRLA--IGPIPTFYK--------RLKAGQK----CFCSDT-------VR 216 Query: 240 DYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKI--PYKVV 297 D++ + D A L+E ++N+ TG G+S+ ++ + G + P VV Sbjct: 217 DFLDMSDFLA---IADLSLQEGRPTGVFNVSTGEGHSIKEVFDVVLDYVGATLAEPVPVV 273 Query: 298 ARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQ 339 A DV + +PS + E GW A + W + Sbjct: 274 APGADDVPSVVLDPSKTETEFGWKAKVDFKDTITGQLAWYDK 315 >1N7G-A nrPDB Length = 381 Score = 226 bits (577), Expect = 7e-60, Method: Composition-based stats. Identities = 64/344 (18%), Positives = 124/344 (36%), Gaps = 34/344 (9%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 + L+TG G GS+ LL GY + + F + + ++ Sbjct: 28 RKIALITGITGQDGSYLTEFLLGKGYEVHGLIRRSSNFNTQ-RINHIYIDPHNVNKALMK 86 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 D+ D +L+R V + A V S + P V TG ++LLE +++ Sbjct: 87 LHYADLTDASSLRRWIDVIKPDEVYNLAAQSHVAVSFEIPDYTADVVATGALRLLEAVRS 146 Query: 122 HGVK-----NLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADK 176 H + + S+ ++G+ P E P +PY SK + +A Sbjct: 147 HTIDSGRTVKYYQAGSSEMFGS-TPPPQSETTPFH-PRSPYAASKCAAHWYTVNYREAYG 204 Query: 177 TW--NAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTED 234 + N +L H S GE + + + ++ +G + L + + Sbjct: 205 LFACNGILFN-------HESPRRGE--NFVTRKITRALGRIKVGLQTKLFL-------GN 248 Query: 235 GTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASG----K 290 RD+ D ++ A+ + +Q Y + T G++V + + G Sbjct: 249 LQASRDWGFAGD----YVEAMWLMLQQEKPDDYVVATEEGHTVEEFLDVSFGYLGLNWKD 304 Query: 291 KIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLW 334 + R +V + S A+E LGW +G +++ + + Sbjct: 305 YVEIDQRYFRPAEVDNLQGDASKAKEVLGWKPQVGFEKLVKMMV 348 >2Q1W-A nrPDB Length = 333 Score = 207 bits (526), Expect = 6e-54, Method: Composition-based stats. Identities = 76/344 (22%), Positives = 126/344 (36%), Gaps = 55/344 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 +KV +TG G IGSH LLE G V IDNF R E L+ ++ F Sbjct: 22 KKVFITGICGQIGSHIAELLLERGDKVVGIDNFATGRR------EHLK-----DHPNLTF 70 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYR---VNLTGTIQLLEIM 119 E I D + +L AV+H A S + P D+Y N G +++ Sbjct: 71 VEGSIADHALVNQLIGDLQPDAVVHTAA------SYKDPDDWYNDTLTNCVGGSNVVQAA 124 Query: 120 KAHGVKNLVFSSSATVYG-NPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTW 178 K + V V+ +A YG P P+ HP + Y SK E+ + Sbjct: 125 KKNNVGRFVYFQTALCYGVKPIQQPVRLDHPRNPANSSYAISKSANEDYL-----EYSGL 179 Query: 179 NAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGV 238 + V R N G + L + +++ G++ + Sbjct: 180 DFVTFRLANVVGPR----------NVSGPLPIFFQRLSEGKKCFVT-----------KAR 218 Query: 239 RDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVA 298 RD++ V DLA+ + A+ + G Y+ +GT ++ ++ A+ +A Y Sbjct: 219 RDFVFVKDLARATVRAV----DGVGHGAYHFSSGTDVAIKELYDAVVEAMALP-SYPEPE 273 Query: 299 RR---EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQ 339 R D + +PS ++ G L + ++ Sbjct: 274 IRELGPDDAPSILLDPSRTIQDFGKIEFTPLKETVAAAVAYFRE 317 >1GFS-A nrPDB Length = 321 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 72/357 (20%), Positives = 122/357 (34%), Gaps = 54/357 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 ++V + G G +GS +L + G + +V+ Sbjct: 4 QRVFIAGHRGMVGSAIRRQLEQRGDVELVLRTR--------------------------- 36 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQK--PLDYYRVNLTGTIQLLEIMK 120 +E+++LD A+ F V A K G P D+ N+ ++ Sbjct: 37 DELNLLDSRAVHDFFASERIDQVY-LAAAKVGGIVANNTYPADFIYQNMMIESNIIHAAH 95 Query: 121 AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA 180 + V L+F S+ +Y P+ E+ G P + + LC++ Sbjct: 96 QNDVNKLLFLGSSCIYPKLAKQPMAESELLQGTLEPTNEPYAIAKIAGIKLCESYNRQYG 155 Query: 181 VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQV--AIGRREALNVFGNDYDT---EDG 235 R PT G +N P S V A+ RR N D G Sbjct: 156 RDYRSVMPTNL----------YGPHDNFHPSNSHVIPALLRRFHEATAQNAPDVVVWGSG 205 Query: 236 TGVRDYIHVVDLAKGHIAALRKLKE------QCGCRIYNLGTGTGYSVLQMVQAMEKASG 289 T +R+++HV D+A I + E Q N+GTG ++ ++ Q + K G Sbjct: 206 TPMREFLHVDDMAAASIHVMELAHEVWLENTQPMLSHINVGTGVDCTIRELAQTIAKVVG 265 Query: 290 KK-IPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFG 345 K ++ +G L Q LGW + L+ ++W +N F Sbjct: 266 YKGRVVFDASKPDGTPRKLLDVTRLHQ--LGWYHEISLEAGLASTYQWFLENQDRFR 320 >3SXP-A nrPDB Length = 362 Score = 201 bits (511), Expect = 3e-52, Method: Composition-based stats. Identities = 82/342 (23%), Positives = 142/342 (41%), Gaps = 48/342 (14%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAG--YLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 + +L+TGGAG++GS+ E VV+D F + + P SL + L G Sbjct: 11 QTILITGGAGFVGSNLAFHFQENHPKAKVVVLDKFRSNTLFSNNRPSSLGHFKNLIGFKG 70 Query: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 E DI + L+RL +K F + H A + Q+ + + N + LLEI + Sbjct: 71 EVIAADINNPLDLRRL-EKLHFDYLFHQAAVSDTTMLNQELV--MKTNYQAFLNLLEIAR 127 Query: 121 AHGVKNLVFSSSATVYGN---PQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKT 177 + ++++SSA VYGN P + +E+ N YG SK ++E + L ++ Sbjct: 128 SKKA-KVIYASSAGVYGNTKAPNVVGKNES-----PENVYGFSKLCMDEFV--LSHSNDN 179 Query: 178 WNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTG 237 V LRYFN G V Q+A+G F E G Sbjct: 180 VQ-VGLRYFNVYGPRE---------FYKEKTASMVLQLALGA----MAFKEVKLFEFGEQ 225 Query: 238 VRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGK------K 291 +RD++++ D+ + ++ A++ K +YN+G S ++V +++ G K Sbjct: 226 LRDFVYIEDVIQANVKAMKAQK----SGVYNVGYSQARSYNEIVSILKEHLGDFKVTYIK 281 Query: 292 IPYKVVARR-EGDVAACYANPSLAQEELGWTAALGLDRMCED 332 PY + + + + L +T L+ +D Sbjct: 282 NPYAFFQKHTQAHIEPTILD-------LDYTPLYDLESGIKD 316 >3M2P-A nrPDB Length = 311 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 62/334 (18%), Positives = 126/334 (37%), Gaps = 46/334 (13%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M+ K+ VTGG G++G + V + G P+++ + + + R Sbjct: 1 MSLKIAVTGGTGFLGQYVVESIKNDGNTPIILTRSIGN-----------KAINDYEYRVS 49 Query: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 ++ D+++Q AV+H A + Q + + N T L + Sbjct: 50 DYTLEDLINQLN--------DVDAVVHLAATRG----SQGKISEFHDNEILTQNLYDACY 97 Query: 121 AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA 180 + + N+V++S+ + Y + LP +E YG SK E + ++ K Sbjct: 98 ENNISNIVYASTISAYSDETSLPWNEKELPLPDLM-YGVSKLACEHIG-NIYSRKKGLCI 155 Query: 181 VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD 240 LR+ + G + + + Q G + L+ + R+ Sbjct: 156 KNLRFAHLYGFNEKNNYM---------INRFFRQAFHGEQLTLHA--------NSVAKRE 198 Query: 241 YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR 300 +++ D AK I AL K++ +N+G+G + ++ + A G K V Sbjct: 199 FLYAKDAAKSVIYAL---KQEKVSGTFNIGSGDALTNYEVANTINNAFGNKDNLLVKNPN 255 Query: 301 EGD-VAACYANPSLAQEELGWTAALGLDRMCEDL 333 + + + Y + S A+E L ++ E++ Sbjct: 256 ANEGIHSSYMDSSKAKELLDFSTDYNFATAVEEI 289 >1WVG-A nrPDB Length = 359 Score = 186 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 75/343 (21%), Positives = 127/343 (37%), Gaps = 23/343 (6%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 ++V VTG G+ GS L L E G ++ + SL E + R+ +L +E Sbjct: 10 KRVFVTGHTGFKGSWLSLWLTEMG---AIVKGYALDAPTVPSLFE-IVRLNDL----MES 61 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 DI D L+ ++ V H A V S ++P+ Y N+ GT+ LLE +K Sbjct: 62 HIGDIRDFEKLRSSIAEFKPEIVFHMAAQPLVRLSYEQPIKTYSTNVMGTVHLLETVKQV 121 Query: 123 G-VKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAV 181 G +K +V +S Y N +++ + G +PY SK E + + Sbjct: 122 GNIKAVVNITSDKCYDNREWVWGYRENEPMGGYDPYSNSKGCAELVASAFRNSFFNPANY 181 Query: 182 LLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDY 241 A IG + L+P + + ++ + + +R + Sbjct: 182 EQHGVGLASVRAGNVIGGGDW-AKDRLIPDILRSFENNQQVI--------IRNPYSIRPW 232 Query: 242 IHVVDLAKGHI-AALRKLKEQCG-CRIYNLGTGTG--YSVLQMVQAMEKASGKKIPYKVV 297 HV++ G+I A R E +N G +V +V M G + + Sbjct: 233 QHVLEPLSGYIVVAQRLYTEGAKFSEGWNFGPRDEDAKTVEFIVDKMVTLWGDDASWLLD 292 Query: 298 ARR-EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQ 339 + + S A +LGW GL + +W K Sbjct: 293 GENHPHEAHYLKLDCSKANMQLGWHPRWGLTETLSRIVKWHKA 335 >4EJ0-A nrPDB Length = 342 Score = 179 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 76/356 (21%), Positives = 125/356 (35%), Gaps = 53/356 (14%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVV-IDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 ++VTG AG+IG++ V L E G ++ +DN A + V+ Sbjct: 13 MTLIVTGAAGFIGANLVKALNERGETRIIAVDNLTRADKFKNL---------------VD 57 Query: 62 FEEMDILDQGALQRLFKKYSF---MAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEI 118 E D LD+ F + F AV H E+ + + N + +L+ Sbjct: 58 CEIDDYLDKTEFVERFARGDFGKVRAVFHEGACSDTMETDGRYM--MDNNFRYSRAVLDA 115 Query: 119 MKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTW 178 A G + +++SSA +YG E N YG SKF +++IR + K+ Sbjct: 116 CLAQGAQ-FLYASSAAIYGGSSRFV--EEREVEAPLNVYGYSKFLFDQVIRRVMPGAKSQ 172 Query: 179 NAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGV 238 RYFN G S G +N + ++ + +FG G Sbjct: 173 -IAGFRYFNVYGPRESHK-GRMASVAFHNFNQFRAEGKV------KLFGEYSGYGPGEQT 224 Query: 239 RDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQ----MVQAMEKASGKKI-- 292 RD++ V D+AK ++ I+NLGTG +V + G+ Sbjct: 225 RDFVSVEDVAKVNLYFFDH---PEKSGIFNLGTGRAQPFNDIAATVVNTLRALEGQPALT 281 Query: 293 --------PYKVVARREGDVAACYANPSLAQEEL---GWT-AALGLDRMCEDLWRW 336 + V + Q +L G+ L + + RW Sbjct: 282 LAEQVEQGLVEYVPFPDALRGKYQCFTQADQTKLRAAGYDAPFLTVQEGVDRYVRW 337 >1RKX-A nrPDB Length = 357 Score = 178 bits (451), Expect = 3e-45, Method: Composition-based stats. Identities = 71/343 (20%), Positives = 131/343 (38%), Gaps = 23/343 (6%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 ++V VTG G+ G L L G + + SL E+ R ++ Sbjct: 10 KRVFVTGHTGFKGGWLSLWLQTMGAT---VKGYSLTAPTVPSLFETAR-----VADGMQS 61 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 E DI DQ L +++ V H A V S +P++ Y N+ GT+ LLE ++ Sbjct: 62 EIGDIRDQNKLLESIREFQPEIVFHMAAQPLVRLSYSEPVETYSTNVMGTVYLLEAIRHV 121 Query: 123 -GVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAV 181 GVK +V +S Y N +++ + G +PY SK E + + A Sbjct: 122 GGVKAVVNITSDKCYDNKEWIWGYRENEAMGGYDPYSNSKGCAELVTSSYRNSFFN-PAN 180 Query: 182 LLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDY 241 ++ +G + + ++P + + A + + + + +R + Sbjct: 181 YGQHGTAVATVRAGNVIGGGDWALDRIVPDILR-AFEQSQPVIIRNPH-------AIRPW 232 Query: 242 IHVVDLAKGHIAALRKL--KEQCGCRIYNLG--TGTGYSVLQMVQAMEKASGKKIPYKVV 297 HV++ G++ +KL +N G V +V+ M K G+ +++ Sbjct: 233 QHVLEPLSGYLLLAQKLYTDGAEYAEGWNFGPNDADATPVKNIVEQMVKYWGEGASWQLD 292 Query: 298 A-RREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQ 339 + + S A+ +LGW L+ E + W K Sbjct: 293 GNAHPHEAHYLKLDCSKAKMQLGWHPRWNLNTTLEYIVGWHKN 335 >4BKP-A nrPDB Length = 336 Score = 172 bits (435), Expect = 2e-43, Method: Composition-based stats. Identities = 72/345 (20%), Positives = 126/345 (36%), Gaps = 42/345 (12%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 + ++LVTGG+G +G VV D + V Sbjct: 22 SMRILVTGGSGLVG---------KAIQKVVADG---------------AGLPGEDWVFVS 57 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKA-VGESVQKPLDYYRVNLTGTIQLLEIMK 120 ++ D+ D + LF+K VIH A + + +++ LD++R N+ +L Sbjct: 58 SKDADLTDTAQTRALFEKVQPTHVIHLAAMVGGLFRNIKYNLDFWRKNVHMNDNVLHSAF 117 Query: 121 AHGVKNLVFSSSATVYGNPQYLPLDEAH----PTGGCTNPYGKSKFFIEEMIRDLCQAD- 175 G + +V S ++ + P+DE P Y +K I+ R Q Sbjct: 118 EVGARKVVSCLSTCIFPDKTTYPIDETMIHNGPPHNSNFGYSYAKRMIDVQNRAYFQQYG 177 Query: 176 KTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDG 235 T+ AV+ N G H + I ED +P + + +A AL V+G G Sbjct: 178 CTFTAVIPT--NVFGPHDNFNI-EDGHVLPG--LIHKVHLAKSSGSALTVWGT------G 226 Query: 236 TGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYK 295 R +I+ +DLA+ I LR+ E I ++G S+ + +A+ +A Sbjct: 227 NPRRQFIYSLDLAQLFIWVLREYNE-VEPIILSVGEEDEVSIKEAAEAVVEAMDFHGEVT 285 Query: 296 VVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQN 340 + A+ S + L + ++ W N Sbjct: 286 FDTTKSDGQFKKTASNSKLRTYLPDFRFTPFKQAVKETCAWFTDN 330 >5YWN-A nrPDB Length = 334 Score = 143 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 82/357 (22%), Positives = 133/357 (37%), Gaps = 52/357 (14%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M V V+G GY+ + +L GY V G E +++L G Sbjct: 1 MTTSVFVSGATGYLAQQIIALVLSKGYKVV----------GSVRSEEKGANLKKLYGDDF 50 Query: 61 EFEEMDILDQ-GALQRLFKKYSFMAVI-HFAG-LKAVGESVQKPLDYYRVNLTGTIQLLE 117 +E + +L+Q GA KK+ + + H A + E +K + +N GT +L+ Sbjct: 51 SYEVVKVLEQKGAFDEALKKHPEVTIFLHTASPVTFEVEDTEKEILIPAIN--GTKYVLQ 108 Query: 118 IMK--AHGVKNLVFSSSATVYGNPQYLPLD--------------EAHPTGGCTNPYGKSK 161 +K A + +V++SS P+ L E T G +G SK Sbjct: 109 SIKDVAPQITRVVYTSSVVAMSVPEELGSPDVVLSEASWSSLSYEQSKTHGVLAYFG-SK 167 Query: 162 FFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRRE 221 F E + + +K A L NP E+ +G N+ V+ V Sbjct: 168 QFAERAAWEFVEQEKPNFA--LSTVNPVYIFGPQAKDEEVKGTLNHSAEMVNSVLK---- 221 Query: 222 ALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTG-TGYSVLQM 280 D D TG +I V D+AK H+AA K E G R+ T G ++L + Sbjct: 222 ----LNKDDDVPATTGT--FIDVRDVAKAHLAAFEK-DEAKGERLLLSNTRFNGQTLLDV 274 Query: 281 VQAMEKASGKKIPYKVVARREGDVAACYA--NPSLAQEELGWTAALGLDRMCEDLWR 335 V+ K+P V + D + + N ++ LG+ + D + Sbjct: 275 VRKNFPQLADKLP---VGKPHSDDFSAFKEWNDKKTKKILGFE-YFDFETSVVDSIK 327 >1EQ2-A nrPDB Length = 310 Score = 141 bits (356), Expect = 3e-34, Method: Composition-based stats. Identities = 72/342 (21%), Positives = 118/342 (34%), Gaps = 48/342 (14%) Query: 5 VLVTGGAGYIGSHTVLELLEAGY-LPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 ++VTGGAG+IGS+ V L + G +V+DN + + V+ Sbjct: 2 IIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDGTKFVNL---------------VDLN 46 Query: 64 EMDILDQGA-LQRLFKKY---SFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIM 119 D +D+ L ++ A+ H + E K + N + +LL Sbjct: 47 IADYMDKEDFLIQIMAGEEFGDVEAIFHEGACSSTTEWDGKYM--MDNNYQYSKELLHYC 104 Query: 120 KAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWN 179 + +++SSA YG + E+ N YG SKF +E +R + + Sbjct: 105 LEREI-PFLYASSAATYGGRTSDFI-ESREYEKPLNVYGYSKFLFDEYVRQILPEANSQ- 161 Query: 180 AVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTG-V 238 V RYFN G ++ VA LN + E Sbjct: 162 IVGFRYFNVYGPREGHKG-------------SMASVAFHLNTQLNNGESPKLFEGSENFK 208 Query: 239 RDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVA 298 RD+++V D+A ++ L E I+NLGTG S + A KK + + Sbjct: 209 RDFVYVGDVADVNLWFL----ENGVSGIFNLGTGRAESFQAVADATLAYH-KKGQIEYIP 263 Query: 299 RREGDVAACYANPSLAQEEL---GW-TAALGLDRMCEDLWRW 336 + A L G+ + + W Sbjct: 264 FPDKLKGRYQAFTQADLTNLRAAGYDKPFKTVAEGVTEYMAW 305 >2X86-A nrPDB Length = 357 Score = 140 bits (353), Expect = 8e-34, Method: Composition-based stats. Identities = 71/342 (20%), Positives = 118/342 (34%), Gaps = 48/342 (14%) Query: 5 VLVTGGAGYIGSHTVLELLEAGY-LPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 ++VTGGAG+IGS+ V L + G +V+DN + + V+ Sbjct: 49 IIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDGTKFVNL---------------VDLN 93 Query: 64 EMDILDQGA-LQRLFKKY---SFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIM 119 D +D+ L ++ A+ H + E K + N + +LL Sbjct: 94 IADYMDKEDFLIQIMAGEEFGDVEAIFHEGACSSTTEWDGKYM--MDNNYQYSKELLHYC 151 Query: 120 KAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWN 179 + +++SSA YG + E+ N +G SKF +E +R + + Sbjct: 152 LEREI-PFLYASSAATYGGRTSDFI-ESREYEKPLNVFGYSKFLFDEYVRQILPEANSQ- 208 Query: 180 AVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTG-V 238 V RYFN G ++ VA LN + E Sbjct: 209 IVGFRYFNVYGPREGHKG-------------SMASVAFHLNTQLNNGESPKLFEGSENFK 255 Query: 239 RDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVA 298 RD+++V D+A ++ L E I+NLGTG S + A KK + + Sbjct: 256 RDFVYVGDVADVNLWFL----ENGVSGIFNLGTGRAESFQAVADATLAYH-KKGQIEYIP 310 Query: 299 RREGDVAACYANPSLAQEEL---GW-TAALGLDRMCEDLWRW 336 + A L G+ + + W Sbjct: 311 FPDKLKGRYQAFTQADLTNLRAAGYDKPFKTVAEGVTEYMAW 352 >2C54-A nrPDB Length = 379 Score = 140 bits (352), Expect = 9e-34, Method: Composition-based stats. Identities = 61/344 (17%), Positives = 118/344 (34%), Gaps = 40/344 (11%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 K+ +TG G+I SH L G+ + D N + EF Sbjct: 31 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCD-------------EFH 77 Query: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKP-LDYYRVNLTGTIQLLEIMKAH 122 +D+ ++ + V + A +Q N + ++E + + Sbjct: 78 LVDLRVMENCLKVTEGV--DHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARIN 135 Query: 123 GVKNLVFSSSATVYG-----NPQYLPLDEAHP-TGGCTNPYGKSKFFIEEMIRDLCQADK 176 G+K ++SSA +Y + L E+ + YG + EE+ + D Sbjct: 136 GIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLERLATEELCKHY-NKDF 194 Query: 177 TWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGT 236 + R+ N G + G + A + ++G DG Sbjct: 195 GIECRIGRFHNIYGPFGTWKGGR------EKAPAAFCRKAQTSTDRFEMWG------DGL 242 Query: 237 GVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKV 296 R + + + +G + L + N+G+ S+ +M + + KK+P Sbjct: 243 QTRSFTFIDECVEGVLR----LTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHH 298 Query: 297 VARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQN 340 + EG V ++ +L +E+LGW + L + W K+ Sbjct: 299 IPGPEG-VRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQ 341 >3WMX-A nrPDB Length = 358 Score = 127 bits (320), Expect = 5e-30, Method: Composition-based stats. Identities = 66/338 (19%), Positives = 119/338 (35%), Gaps = 42/338 (12%) Query: 4 KVLVTGGAGYIGSHTVLELLEA-GYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 K+L+ G G IGS L L E G V+ + R + Sbjct: 27 KILIVGANGQIGSELALALAERYGRTNVITSDVVPTGR----------------HVHLTH 70 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAG-LKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 E ++ D+G L + +++ V A L A GE + P + +N+T + +LE+ + Sbjct: 71 EMLNATDRGELATVVERHGITQVYLLAAALSATGE--KAPQWAWNLNMTSLLNVLELARQ 128 Query: 122 HGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAV 181 G++ + + SS +G T YG SK E R A+ + Sbjct: 129 TGLERVFWPSSIAAFGPTTPAGQTPQKTVMEPTTVYGISKQAGEGWCRWY-HANHGVDVR 187 Query: 182 LLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDY 241 +RY G + + A+ D Sbjct: 188 SVRYPGLISHKTPPGGGTTDYAVD------IFHAAVTGEPYTCFLKEDEALPM------- 234 Query: 242 IHVVDLAKGHIAALRKLKEQ-CGCRIYNLGTGTGYSVLQMVQAMEKAS-GKKIPYKVVAR 299 +++ D + I + ++ YN+ G ++ Q+ A+ + G +I Y+ R Sbjct: 235 MYMPDAIRATIELMEAPADKLSERGSYNIA-GMSFTPAQIAAAIREQVPGFQIRYEPDYR 293 Query: 300 RE---GDVAACYANPSLAQEELGWTAALGLDRMCEDLW 334 + G + + S+A+ + GW A GL M D+ Sbjct: 294 QAIAQGWPDS--IDDSVARADWGWKAQYGLKEMVADML 329 >6AQY-A nrPDB Length = 341 Score = 127 bits (320), Expect = 5e-30, Method: Composition-based stats. Identities = 54/351 (15%), Positives = 122/351 (34%), Gaps = 57/351 (16%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF-- 62 +LVTGG G G E + + +++ G+ V Sbjct: 27 ILVTGGTGLFGKAV----------------------------EHIVKKEQIKGKWVFLGS 58 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAG-LKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 ++ D+ D A ++ F+KY VIH A + + +++ + ++ N+ +L Sbjct: 59 KDGDLRDADACKQPFEKYRPTYVIHLAAFVGGLFKNMNFKVSFWLDNVNMNNNILTCCYD 118 Query: 122 HGVKNLVFSSSATVYGNPQYLPLDEAH----PTGGCTNPYGKSKFFIEEMIRDLCQ---- 173 GVK + S V+ + P+ E P N Y +K ++ + R + Sbjct: 119 FGVKKTISCLSTCVFPDKIEYPITEEKLHEGPPHFSNNAYAYAKRMLDMLGRWYNEKAVN 178 Query: 174 ADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDT- 232 K+ + N G H + + +++P + ++ G D+ Sbjct: 179 EGKSCLFTSVIPTNLFGPHDNFNVEA------GHVLPGLMHKCYKAQQN----GTDFVVF 228 Query: 233 EDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKI 292 G +R +++ D A+ + + + + + S+ Q+ Q ++ A Sbjct: 229 GSGKPLRQFLYSHDAARMLLWTMFNY-QSEEPIMLCVSEEDEKSIGQVAQTIKDAFNFTG 287 Query: 293 P-YKVVARREGDVAACYANPS--LAQEELGWTAALGLDRMCEDLWRWQKQN 340 ++ +G +N +T ++ ++ +W +N Sbjct: 288 NMVFDTSKADGQYKKTSSNAKFLRLNPTFQYTP---FEQAIKETVQWFLEN 335 >4WKG-A nrPDB Length = 660 Score = 126 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 60/361 (16%), Positives = 109/361 (30%), Gaps = 47/361 (13%) Query: 2 AEKVLVTGGAGYIGSHTVLELL-EAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 +VL+ G G+IG+H LL E Y +D +A L Sbjct: 315 RTRVLILGVNGFIGNHLTERLLREDHYEVYGLDIGSDAISRF------------LNHPHF 362 Query: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 F E DI K V+ + E + PL + ++ ++++ Sbjct: 363 HFVEGDISIHSEWIEYHVK-KCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYCV 421 Query: 121 AHGVKNLVFSSSATVYGNPQYLPLDEAH------PTGGCTNPYGKSKFFIEEMIRDLCQA 174 + K ++F S++ VYG DE H P Y SK ++ +I + Sbjct: 422 KYR-KRIIFPSTSEVYGMCSDKYFDEDHSNLIVGPVNKPRWIYSVSKQLLDRVIWAYGEK 480 Query: 175 DKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTED 234 + L R FN G G + + + G L + Sbjct: 481 E-GLQFTLFRPFNWMGPRLDNLNAARI-GSSRAITQLILNLVEGSPIKL--------IDG 530 Query: 235 GTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGT-GTGYSVLQMVQAMEKASGKKIP 293 G R + + D + + +C I N+G S+ ++ + + + K Sbjct: 531 GKQKRCFTDIRDGIEALYRIIENAGNRCDGEIINIGNPENEASIEELGEMLLASFEKHPL 590 Query: 294 YKVVARREG---------------DVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQK 338 G DV + A L W + + ++ + Sbjct: 591 RHHFPPFAGFRVVESSSYYGKGYQDVEHRKPSIRNAHRCLDWEPKIDMQETIDETLDFFL 650 Query: 339 Q 339 + Sbjct: 651 R 651 >5B6K-A nrPDB Length = 366 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 75/363 (20%), Positives = 120/363 (33%), Gaps = 46/363 (12%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 V V+G G+I H V +LL+ Y + + L+ V G Sbjct: 22 TTVFVSGATGFIAQHVVRQLLDQNYKVI-------GSVRSAEKGDHLKNVIFKGGDFNYE 74 Query: 63 EEMDILDQGALQRLFKKY--SFMAVIHFAG-LKAVGESVQKPLDYYRVNLTGTIQLLEIM 119 DI D A +F+K+ V+H A ++K L VN GT +LE + Sbjct: 75 IVKDISDPTAFDHVFEKHGKDIKVVLHTASPFHFNTTDIEKDLLIPAVN--GTKGILESI 132 Query: 120 KAH---GVKNLVFSSS--------ATVYGNPQYLPLDEAH--------PTGGCTNPYGKS 160 K + V+ +V +SS Y + E Y S Sbjct: 133 KKYAAQTVERVVVTSSFAANTSTVDMFYAKDSSKTITEESWNQDTWESCQSDPIRGYCGS 192 Query: 161 KFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRR 220 K F E+ D A+K L NP E + I N ++ + ++ Sbjct: 193 KKFAEKAAWDFYNANKDSVKFKLSIINPVYVFGPQNYVEPGKKILNTSSEVINSLVHLKK 252 Query: 221 E-ALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQ 279 + L F + I V D+AK HI A +K + + + G T ++L Sbjct: 253 DDPLPEFAGGH-----------IDVRDVAKAHILAFQKDELIEQRLMLHAGLFTTQTLLD 301 Query: 280 MVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWT---AALGLDRMCEDLWRW 336 ++ KIP D A + S ++ LG+ L + Sbjct: 302 IINEQFPELKGKIPAGKPGTGNPDDALTPVDNSKTKKLLGFEFIDLKKDLYDTISQILEA 361 Query: 337 QKQ 339 +K Sbjct: 362 EKN 364 >2NNL-D nrPDB Length = 337 Score = 115 bits (287), Expect = 4e-26, Method: Composition-based stats. Identities = 68/355 (19%), Positives = 121/355 (34%), Gaps = 75/355 (21%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTG---- 57 +E V VTG +G+IGS V+ LLE GY R P ++++V+ L Sbjct: 5 SETVCVTGASGFIGSWLVMRLLERGYTV----------RATVRDPTNVKKVKHLLDLPKA 54 Query: 58 -RSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVN-----LTG 111 + + D+ D+G+ K V H A P+D+ + + Sbjct: 55 ETHLTLWKADLADEGSFDEAIKGC--TGVFHVAT----------PMDFESKDPENEVIKP 102 Query: 112 TIQ-LLEIMK----AHGVKNLVFSSSA-TVYGNPQYLPLDEAHPTGGCTN---------P 156 TI+ +L IMK A V+ LVF+SSA TV LP+ + Sbjct: 103 TIEGMLGIMKSCAAAKTVRRLVFTSSAGTVNIQEHQLPVYDESCWSDMEFCRAKKMTAWM 162 Query: 157 YGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVA 216 Y SK E+ + + + + + G + + + + + Sbjct: 163 YFVSKTLAEQAAWKYAK-ENNIDFITIIPTLVVGPFIMSSMPPSLITALSPITGNEAHYS 221 Query: 217 IGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYS 276 I R+ ++H+ DL HI K + + + Sbjct: 222 IIRQG------------------QFVHLDDLCNAHIYLFENPKAEGRY----ICSSHDCI 259 Query: 277 VLQMVQAMEKASGKKIPYKVVARREG--DVAACYANPSLAQEELGWTAALGLDRM 329 +L + + + + K Y + +G + S +LG+ L+ M Sbjct: 260 ILDLAKMLRE---KYPEYNIPTEFKGVDENLKSVCFSSKKLTDLGFEFKYSLEDM 311 >4PVC-A nrPDB Length = 342 Score = 99.1 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 66/357 (18%), Positives = 116/357 (32%), Gaps = 52/357 (14%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 V V+G G+I H V LL+ Y + G E + E G + +F Sbjct: 1 MSVFVSGANGFIAQHIVDLLLKEDYKVI----------GSARSQEKAENLTEAFGNNPKF 50 Query: 63 ---EEMDILDQGALQRLFKKY--SFMAVIHFAG--LKAVGESVQKPLDYYRVNLTGTIQL 115 DI A +F+K+ V+H A + +S + L + G + Sbjct: 51 SMEVVPDISKLDAFDHVFQKHGKDIKIVLHTASPFCFDITDSERDLLIPAVNGVKG---I 107 Query: 116 LEIMKAH---GVKNLVFSSS-------------ATVYGNPQYLPLDEAHPTGGCTNPYGK 159 L +K + V+ +V +SS + + + P N Y Sbjct: 108 LHSIKKYAADSVERVVLTSSYAAVFDMAKENDKSLTFNEESWNPATWESCQSDPVNAYCG 167 Query: 160 SKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVA-IG 218 SK F E+ + + ++ L NP +D + N V+ + + Sbjct: 168 SKKFAEKAAWEFLEENRDSVKFELTAVNPVYVFGPQMFDKDVKKHLNTSCELVNSLMHLS 227 Query: 219 RREALN-VFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSV 277 + + +FG YI V D+AK H+ A +K + I + T V Sbjct: 228 PEDKIPELFGG------------YIDVRDVAKAHLVAFQKRETIGQRLIVSEARFTMQDV 275 Query: 278 LQMVQAMEKASGKKIPYKVVARREGDV-AACYANPSLAQEELGWTAALGLDRMCEDL 333 L ++ IP + +++ LG+ L +D Sbjct: 276 LDILNEDFPVLKGNIPVGKPGSGATHNTLGATLDNKKSKKLLGFKFR-NLKETIDDT 331 >4R1T-A nrPDB Length = 337 Score = 98.7 bits (244), Expect = 3e-21, Method: Composition-based stats. Identities = 62/348 (17%), Positives = 105/348 (30%), Gaps = 51/348 (14%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + V VTG G+I S V LLE GY R R E + Sbjct: 11 QVVCVTGAGGFIASWLVKILLEKGYTV------RGTVRNPDDPKNGHLRELEGAKERLTL 64 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 + D+LD +L+ V H A P + GT ++ Sbjct: 65 CKADLLDYQSLREAINGC--DGVFHTASPV-----TDDPEQMVEPAVIGTKNVINAAAEA 117 Query: 123 GVKNLVFSSSA-TVYGNPQYLP---LDEAHPTGG-----CTNPYGKSKFFIEEMIRDLCQ 173 V+ +VF+SS VY +P P +DE + N Y K E+ + Sbjct: 118 NVRRVVFTSSIGAVYMDPNRDPETVVDETCWSDPDFCKNTKNWYCYGKMVAEQAAWE-EA 176 Query: 174 ADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTE 233 +K + V++ G + I L G+ Sbjct: 177 KEKGVDLVVINPVLVQGPLLQTTVNASVLHILKYLT-----------------GSAKTYA 219 Query: 234 DGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKAS-GKKI 292 + Y+ V D+A HI + Y + +V+ + K I Sbjct: 220 NSVQA--YVDVKDVALAHIL---LYETPEASGRYLCAESVLHR-GDVVEILSKFFPEYPI 273 Query: 293 PYKVVARREGDVAACYANPSLAQEE-LGWTAALGLDRMCEDLWRWQKQ 339 P K + V + ++ L +T + + + + ++ Sbjct: 274 PTKCSDVTKPRVKPYKFSNQKLKDLGLEFTP---VKQCLYETVKSLQE 318 >3HFS-A nrPDB Length = 338 Score = 97.9 bits (242), Expect = 5e-21, Method: Composition-based stats. Identities = 61/354 (17%), Positives = 118/354 (33%), Gaps = 48/354 (13%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + V GG G++ S V LL+ GY N L +QEL ++ Sbjct: 10 KTACVVGGTGFVASLLVKLLLQKGYAV----NTTVRDPDNQKKVSHLLELQEL--GDLKI 63 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPL-DYYRVNLTGTIQLLEIM-K 120 D+ D+ + + F V H A + P D + + G + +++ + Sbjct: 64 FRADLTDELSFEAPIAGCDF--VFHVATPVHFAS--EDPENDMIKPAIQGVVNVMKACTR 119 Query: 121 AHGVKNLVFSSSAT------------VYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMI 168 A VK ++ +SSA V + ++ T Y SK E+ Sbjct: 120 AKSVKRVILTSSAAAVTINQLDGTGLVVDEKNWTDIEFLTSAKPPTWGYPASKTLAEKAA 179 Query: 169 RDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQ--GIPNNLMPYVSQVAIGRREALNVF 226 + + + L PT S + P G+ +L+ + G + + Sbjct: 180 WKFAEENN----IDLITVIPTLMAGSSLTSDVPSSIGLAMSLITGNEFLINGMKGMQMLS 235 Query: 227 GNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEK 286 G+ HV D+ + HI K + Y + SV ++ + + K Sbjct: 236 GSVSIA----------HVEDVCRAHIFVAEK---ESASGRY-ICCAANTSVPELAKFLSK 281 Query: 287 -ASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQ 339 K+P + + +E G++ G++ + ++ + K Sbjct: 282 RYPQYKVPTDFGDFPPK--SKLIISSEKLVKE-GFSFKYGIEEIYDESVEYFKA 332 >2GN9-A nrPDB Length = 344 Score = 96.0 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 49/312 (15%), Positives = 104/312 (33%), Gaps = 54/312 (17%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + +L+TGG G G V ++L+ +I + + E + F Sbjct: 22 QTILITGGTGSFGKCFVRKVLDTTNAKKIIVYSRDELKQSEMAME-------FNDPRMRF 74 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 D+ D L + IH A LK V + PL+ + N+ G ++ + Sbjct: 75 FIGDVRDLERLNYALEGVDI--CIHAAALKHVPIAEYNPLECIKTNIMGASNVINACLKN 132 Query: 123 GVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIR--DLCQADKTWNA 180 + ++ S+ N YG +K +++ + + Sbjct: 133 AISQVIALSTDKA---------------ANPINLYGATKLCSDKLFVSANNFKGSSQTQF 177 Query: 181 VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD 240 ++RY N G+ S ++P+ ++ + + + D R Sbjct: 178 SVVRYGNVVGSRGS-------------VVPFFKKLVQNKASEIPI-------TDIRMTRF 217 Query: 241 YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR 300 +I + + + +L+++ G I+ ++M + KA P K++ R Sbjct: 218 WITLDEGVSFVLKSLKRMH---GGEIFV----PKIPSMKMTD-LAKALAPNTPTKIIGIR 269 Query: 301 EGDVAACYANPS 312 G+ P Sbjct: 270 PGEKLHEVMIPK 281 >2P4H-X nrPDB Length = 322 Score = 95.6 bits (236), Expect = 3e-20, Method: Composition-based stats. Identities = 64/350 (18%), Positives = 120/350 (34%), Gaps = 48/350 (13%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 +V VTGG G++GS + LLE GY + S +L E + F Sbjct: 3 RVCVTGGTGFLGSWIIKSLLENGYSVNTTIRADPERKRDVSFLTNLPGASE----KLHFF 58 Query: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHG 123 D+ + + + + + H A S + + R + G + +L+ Sbjct: 59 NADLSNPDSFAAAIEGC--VGIFHTASPIDFAVSEPEEIVTKRT-VDGALGILKACVNSK 115 Query: 124 -VKNLVFSS--SATVYGNPQYLPLDEAH--------PTGGCTNPYGKSKFFIEEMIRDLC 172 VK +++S SA + LDE+ Y SK E+ + + Sbjct: 116 TVKRFIYTSSGSAVSFNGKDKDVLDESDWSDVDLLRSVKPFGWNYAVSKTLAEKAVLEFG 175 Query: 173 QADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDT 232 + + V L +G + + + +G++E + Sbjct: 176 EQ-NGIDVVTL--------ILPFIVGRFVCPKLPDSIEKALVLVLGKKEQI--------- 217 Query: 233 EDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKI 292 G +HV D+A+ HI L+ YN + + +M Q + S K Sbjct: 218 --GVTRFHMVHVDDVARAHIY---LLENSVPGGRYN-CSPFIVPIEEMSQLL---SAKYP 268 Query: 293 PYKVVARREGDVAACYANPSLAQEEL---GWTAALGLDRMCEDLWRWQKQ 339 Y+++ E P L ++L G+ ++ M +D + K+ Sbjct: 269 EYQILTVDELKEIKGARLPDLNTKKLVDAGFDFKYTIEDMFDDAIQCCKE 318 >4R1U-A nrPDB Length = 349 Score = 91.8 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 63/350 (18%), Positives = 113/350 (32%), Gaps = 55/350 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTG--RSV 60 + V VTG G+I S V LLE GY P++ ++EL G + Sbjct: 28 QTVCVTGAGGFIASWLVKLLLERGYTV-------RGTVRNPEDPKN-GHLKELEGARERL 79 Query: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 ++D+LD ++Q + V H A P + + GT ++ Sbjct: 80 TLHKVDLLDLQSIQSVVHGCH--GVFHTASPV-----TDNPDEMLEPAVNGTKNVIIASA 132 Query: 121 AHGVKNLVFSSSA-TVYGNPQY---LPLDEA-----HPTGGCTNPYGKSKFFIEEMIRDL 171 V+ +VF+SS TVY +P + +DE+ N Y K E+ D+ Sbjct: 133 EAKVRRVVFTSSIGTVYMDPNTSRDVVVDESYWSDLEHCKNTKNWYCYGKTVAEQSAWDI 192 Query: 172 CQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYD 231 + + L P + + + N Sbjct: 193 AKE--------------------NQVDLVVVNPVVVLGPLLQPTINASTIHILKYLNGAA 232 Query: 232 TEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKAS-GK 290 + Y+HV D+A H+ Y + T ++V+ + K Sbjct: 233 KTYVNATQSYVHVKDVALAHLLVYET---NSASGRY-ICCETALHRGEVVEILAKYFPEY 288 Query: 291 KIPYKVVARREGDVAACYANPSLAQEE-LGWTAALGLDRMCEDLWRWQKQ 339 +P K + V + ++ L +T + + D R ++ Sbjct: 289 PLPTKCSDEKNPRVKPYKFSNQKLKDLGLEFTP---VKQCLYDTVRSLQE 335 >4QUK-A nrPDB Length = 319 Score = 90.6 bits (223), Expect = 9e-19, Method: Composition-based stats. Identities = 66/352 (18%), Positives = 117/352 (33%), Gaps = 54/352 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTG--RSV 60 V VTG +GYI S V LL GY A + P+ + + +L G + Sbjct: 1 NVVCVTGASGYIASWLVRLLLHRGYTV-------KATVRDPNDPKKVDHLVKLDGAKERL 53 Query: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDY-YRVNLTGTIQLLEIM 119 + + ++L++GA + + V H A V+ P L GT+ +L Sbjct: 54 QLFKANLLEEGAFDSVVQGCH--GVFHTA--SPFYHDVKDPQAELIDPALKGTLNVLNSC 109 Query: 120 -KAHGVKNLVFSSS--ATVYGNPQYLP---LDEAHPTGG-----CTNPYGKSKFFIEEMI 168 K+ +K +V +SS A Y P +DE T Y S EE Sbjct: 110 AKSPSLKRVVLTSSIAAVAYNGKPRTPDVVVDETWFTDADFCAKSNLWYVVSATLAEEAA 169 Query: 169 RDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGN 228 + + + V + G L P ++ A +N Sbjct: 170 WKFVK-ENNIDMVTINPAMVIGPL---------------LQPVLNTSAAAILNLINGAQT 213 Query: 229 DYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKAS 288 + G +++V D+A HI A + L + ++V+ + + Sbjct: 214 FPNASFG-----WVNVKDVANAHILAYE---NASASGRHCLVERVAH-YSEVVRILRELY 264 Query: 289 GKKIPYKVVARREGDVAACYANPSLAQEE-LGWTAALGLDRMCEDLWRWQKQ 339 + A + V + A+ L +T L+ ++ K+ Sbjct: 265 PSLQLPEKCADDKPYVPIYQVSKEKAKSLGLEYTP---LEVSIKETVESLKE 313 >4G5H-A nrPDB Length = 363 Score = 90.2 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 47/317 (14%), Positives = 105/317 (33%), Gaps = 62/317 (19%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 +L+TGG G G+ + L++ + I F + + ++ ++F Sbjct: 28 LLITGGTGSFGNAVMKRFLDSNIKEIRI--FSRDEKKQDDIR------KKYNNSKLKFYI 79 Query: 65 MDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGV 124 D+ D +++ + V H A LK V P++ + N+ GT +L+ V Sbjct: 80 GDVRDSQSVETAMR--DVDYVFHAAALKQVPSCEFFPVEAVKTNIIGTENVLQSAIHQNV 137 Query: 125 KNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVL-- 182 K ++ S+ N G SK +E++ + ++ ++ Sbjct: 138 KKVICLSTDKA---------------AYPINAMGISKAMMEKVFVAKSRNIRSEQTLICG 182 Query: 183 LRYFNPTGAHASGCIGEDPQGIPNNLMP-YVSQVAIGRREALNVFGNDYDTEDGTGVRDY 241 RY N + S ++P ++ ++ G + D R Sbjct: 183 TRYGNVMASRGS-------------VIPLFIDKIKAGEPLTIT---------DPDMTRFL 220 Query: 242 IHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARRE 301 + + D + + A + + +V + A+ + +++ R Sbjct: 221 MSLEDAVELVVHAFKHA----ETGDIMVQKAPSSTVGDLATALLELFEADNAIEIIGTRH 276 Query: 302 GDVAACYANPSLAQEEL 318 G+ A+ L Sbjct: 277 GE--------KKAETLL 285 >4J2O-A nrPDB Length = 363 Score = 87.2 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 47/264 (17%), Positives = 90/264 (34%), Gaps = 52/264 (19%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + +L+TGG G G+ + LE + I + ++ ++F Sbjct: 24 KVLLITGGTGSFGNAVLKRFLETDIKEIRI--------FSRDEKKQDDMRKKYHSAKLKF 75 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 D+ D ++ + + H A LK V P++ + N+ GT +LE + Sbjct: 76 YIGDVRDYNSILNATRGV--DYIYHAAALKQVPSCEFHPMEAVKTNVLGTENVLEAAIQN 133 Query: 123 GVKNLVFSSSA-TVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAV 181 VK +V S+ VY N G SK +E+++ + + + V Sbjct: 134 HVKRVVCLSTDKAVY----------------PINAMGISKAMMEKVMVAKSRNLEGLDTV 177 Query: 182 L--LRYFNPTGAHASGCIGEDPQGIPNNLMP-YVSQVAIGRREALNVFGNDYDTEDGTGV 238 + RY N + S ++P +V Q+ G+ + D Sbjct: 178 ICGTRYGNVMASRGS-------------VIPLFVDQIRQGKPLTIT---------DPNMT 215 Query: 239 RDYIHVVDLAKGHIAALRKLKEQC 262 R + + D + A + Sbjct: 216 RFMMTLEDAVDLVLYAFEHGENGD 239 >1VL0-A nrPDB Length = 292 Score = 85.2 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 48/309 (15%), Positives = 92/309 (29%), Gaps = 65/309 (21%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 K+L+TG G +G +L + D Sbjct: 13 MKILITGANGQLGREIQKQLKGKNVEVIPTD----------------------------V 44 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 +++DI + A+ + F + VI+ A AV + ++ Y++N G L + Sbjct: 45 QDLDITNVLAVNKFFNEKKPNVVINCAAHTAVDKCEEQYDLAYKINAIGPKNLAAAAYSV 104 Query: 123 GVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVL 182 G + +V S+ V+ P+ E + YGK+K E ++ L Sbjct: 105 GAE-IVQISTDYVFDGEAKEPITEFDEV-NPQSAYGKTKLEGENFVKALNPKYYIVRTAW 162 Query: 183 LRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYI 242 L G NN + + + + L V + T T Sbjct: 163 L------------------YGDGNNFVKTMINLGK-THDELKVVHDQVGTPTST------ 197 Query: 243 HVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVA---- 298 VDLA+ + + ++ ++ S + + +G + Sbjct: 198 --VDLARVVLKVI----DEKNYGTFHCTCKGICSWYDFAVEIFRLTGIDVKVTPCTTEEF 251 Query: 299 RREGDVAAC 307 R Sbjct: 252 PRPAKRPKY 260 >5U9C-A nrPDB Length = 292 Score = 83.3 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 46/218 (21%), Positives = 72/218 (33%), Gaps = 42/218 (19%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M K+L+TGG G +G++ L + Y +V + R L+ Sbjct: 4 MKRKILITGGTGMLGAYVTSALKDTDYNVIVTE----------------RNTLNLSVPEA 47 Query: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 F ++HFA V ++P N T Q+ + K Sbjct: 48 IFSY------------ITAEKPDVILHFAAETDVDLCEREPARAGIYNHLATEQIAQAAK 95 Query: 121 AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA 180 G L++ SS+ V+G L +E N YG+SK E +R+ C Sbjct: 96 FCGA-WLLYLSSSNVFGGEGKLSYNELD-IPLPMNYYGRSKLIGESSVRNAC-------- 145 Query: 181 VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIG 218 N A IG P + + Q+ G Sbjct: 146 ----TNNHLIIRAGWMIGGGPDKDHKFVGKIIQQIKAG 179 >3RFT-A nrPDB Length = 267 Score = 81.0 bits (198), Expect = 8e-16, Method: Composition-based stats. Identities = 43/173 (24%), Positives = 64/173 (36%), Gaps = 30/173 (17%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 +++LVTG AG +G L + + D + G + E Sbjct: 4 KRLLVTGAAGQLGRVMRERLAPMAEILRLAD----------------LSPLDPAGPNEEC 47 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKP-LDYYRVNLTGTIQLLEIMKA 121 + D+ D A+ + ++H G SV+KP + N+ G L E +A Sbjct: 48 VQCDLADANAVNAMVAGC--DGIVHLG-----GISVEKPFEQILQGNIIGLYNLYEAARA 100 Query: 122 HGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNP---YGKSKFFIEEMIRDL 171 HG +VF+SS G Y P E P YG SK F E + R Sbjct: 101 HGQPRIVFASSNHTIG---YYPQTERLGPDVPARPDGLYGVSKCFGENLARMY 150 >4WPG-A nrPDB Length = 289 Score = 81.0 bits (198), Expect = 8e-16, Method: Composition-based stats. Identities = 42/219 (19%), Positives = 73/219 (33%), Gaps = 38/219 (17%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 +L+TG G +G+ L E G V +D E Sbjct: 7 ILITGSNGQLGTELRYLLDERGVDYVAVD----------------------------VAE 38 Query: 65 MDILDQGALQRLFKKYSFMAVIHFAGLKAVGES-VQKPLDYYRVNLTGTIQLLEIMKAHG 123 MDI ++ ++ +F + V H A AV + + +N+TG+ + + +G Sbjct: 39 MDITNEDKVEAVFAQVKPTLVYHCAAYTAVDAAEDEGKALNEAINVTGSENIAKACGKYG 98 Query: 124 VKNLVFSSSATVYG--NPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAV 181 LV+ S+ V+ P E T YG++K E + + Sbjct: 99 A-TLVYISTDYVFDGNKPVGQEWVETDHPDPKTE-YGRTKRLGELAVERYAEHFY----- 151 Query: 182 LLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRR 220 ++R G + + Q N+ V GR Sbjct: 152 IIRTAWVFGNYGKNFVFTMEQLAENHSRLTVVNDQHGRP 190 >4KTT-E nrPDB Length = 327 Score = 80.2 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 56/338 (16%), Positives = 102/338 (30%), Gaps = 53/338 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 +VLVTG G +G E + + V FR +F Sbjct: 22 RRVLVTGATGLLGRAVHKEFQQNNWHAVGC-----GFRRA----------------RPKF 60 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 E++++LD A+ + + ++H A + +P ++N+ + L + A Sbjct: 61 EQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNLAKEAAAV 120 Query: 123 GVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVL 182 G L++ SS V+ + P E N YGK+K E+ + + A + Sbjct: 121 GA-FLIYISSDYVF-DGTNPPYREED-IPAPLNLYGKTKLDGEKAVLE-----NNLGAAV 172 Query: 183 LRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYI 242 LR G L V + + F N D R Sbjct: 173 LRI-------------PILYGEVEKLEESAVTVMFDKVQ----FSNKSANMDHWQQRFPT 215 Query: 243 HVVDLAKG-HIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIP-----YKV 296 HV D+A A +++ + ++ + +M A+ A Sbjct: 216 HVKDVATVCRQLAEKRMLDPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDS 275 Query: 297 VARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLW 334 + S + LG ++ Sbjct: 276 PVLGAQRPRNAQLDCSKLET-LGIGQRTPFRIGIKESL 312 >3SC6-A nrPDB Length = 287 Score = 79.4 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 51/294 (17%), Positives = 98/294 (33%), Gaps = 60/294 (20%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M E+V++TG G +G EL Y D Sbjct: 4 MKERVIITGANGQLGKQLQEELNPEEYDIYPFDK-------------------------- 37 Query: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 + +DI + +Q++ ++ +IH A V ++ ++ Y +N G + + Sbjct: 38 --KLLDITNISQVQQVVQEIRPHIIIHCAAYTKVDQAEKERDLAYVINAIGARNVAVASQ 95 Query: 121 AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA 180 G LV+ S+ V+ + DE H N YG SK+ E+ +++L Sbjct: 96 LVGA-KLVYISTDYVFQGDRPEGYDEFHNP-APINIYGASKYAGEQFVKELHNKYFIVRT 153 Query: 181 VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD 240 L + G NN + + ++ RE ++V + + Sbjct: 154 SWL--YGKYG---------------NNFVKTMIRLGKE-REEISVVADQIGSP------- 188 Query: 241 YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPY 294 +V DL + KL Y++ S + + + + K+ Sbjct: 189 -TYVADLN----VMINKLIHTSLYGTYHVSNTGSCSWFEFAKKIFSYANMKVNV 237 >1KC3-A nrPDB Length = 299 Score = 76.8 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 58/318 (18%), Positives = 99/318 (31%), Gaps = 49/318 (15%) Query: 35 FHNAFRGGGSLPESLRRVQELTGRSVEFEE--MDILDQGALQRLFKKYSFMAVIHFAGLK 92 F + G L SL V L V +E D + + +K +++ A Sbjct: 6 FGKTGQVGWELQRSLAPVGNLIALDVHSKEFCGDFSNPKGVAETVRKLRPDVIVNAAAHT 65 Query: 93 AVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGG 152 AV ++ +P +N T + + G +V S+ V+ +P E T Sbjct: 66 AVDKAESEPELAQLLNATSVEAIAKAANETGA-WVVHYSTDYVFPGTGDIPWQETDAT-S 123 Query: 153 CTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYV 212 N YGK+K E+ ++D C ++ R G NN + Sbjct: 124 PLNVYGKTKLAGEKALQDNCPKH-----LIFRTSWVY------------AGKGNNFAKTM 166 Query: 213 SQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCG-CRIYNLGT 271 ++A R+ L+V + Y G LA A+R + +Y+L Sbjct: 167 LRLAKERQ-TLSVINDQYGAPTG--------AELLADCTAHAIRVALNKPEVAGLYHLVA 217 Query: 272 GTGYSVLQMVQAMEKASGK-----------KIPYKVVARREGDVAACYANPSLAQEELG- 319 G + + + K +P N Q Sbjct: 218 GGTTTWHDYAALVFDEARKAGITLALTELNAVPTSAYPTPASRPGNSRLNTEKFQRNFDL 277 Query: 320 ----WTAALGLDRMCEDL 333 W LG+ RM ++ Sbjct: 278 ILPQW--ELGVKRMLTEM 293 >2GGS-A nrPDB Length = 273 Score = 73.7 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 52/323 (16%), Positives = 95/323 (29%), Gaps = 71/323 (21%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + L+TG +G +G L E VI ++++ GG Sbjct: 1 MRTLITGASGQLGIELSRLLSERHE---VIKVYNSSEIQGG------------------- 38 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 ++D+ D L+ K +I+ A + V + + Y++N ++ K Sbjct: 39 YKLDLTDFPRLEDFIIKKRPDVIINAAAMTDVDKCEIEKEKAYKINAEAVRHIVRAGKVI 98 Query: 123 GVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVL 182 +V S+ V+ + +E P N YG SK E Sbjct: 99 D-SYIVHISTDYVFDGEKGNYKEEDIP--NPINYYGLSKLLGETFALQ------------ 143 Query: 183 LRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYI 242 S I YV + + G Sbjct: 144 ---------DDSLIIRTSGIFRNKGFPIYVYKTLKEGKTVFAFKGYYSPIS--------- 185 Query: 243 HVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVV----- 297 A+ +A+ +L E I ++ G S ++ +++ K V Sbjct: 186 -----ARKLASAILELLELRKTGIIHVA-GERISRFELALKIKEKFNLPGEVKEVDEVRG 239 Query: 298 --ARREGDVAACYANPSLAQEEL 318 A+R D + S A++ L Sbjct: 240 WIAKRPYD---SSLDSSRARKIL 259 >1ZZE-A nrPDB Length = 342 Score = 71.0 bits (172), Expect = 8e-13, Method: Composition-based stats. Identities = 52/205 (25%), Positives = 72/205 (35%), Gaps = 35/205 (17%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF-E 63 VLVTG G++ SH V +LLE GY R L +R E Sbjct: 14 VLVTGANGFVASHVVEQLLEHGYKV------RGTARSASKLANLQKRWDAKYPGRFETAV 67 Query: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHG 123 D+L QGA + K + V H A + + + + + GT+ L A Sbjct: 68 VEDMLKQGAYDEVIKGAA--GVAHIASVVSFSNKYDEVVTPA---IGGTLNALRAAAATP 122 Query: 124 -VKNLVFSSS--ATVYGNPQYLPL--DEAH---------PTGGCTNP------YGKSKFF 163 VK V +SS + + P + DE T ++P Y SK Sbjct: 123 SVKRFVLTSSTVSALIPKPNVEGIYLDEKSWNLESIDKAKTLPESDPQKSLWVYAASKTE 182 Query: 164 IEEMIRDLCQADK---TWNAVLLRY 185 E +K T NAVL Y Sbjct: 183 AELAAWKFMDENKPHFTLNAVLPNY 207 >4QQR-A nrPDB Length = 301 Score = 61.3 bits (147), Expect = 5e-10, Method: Composition-based stats. Identities = 31/180 (17%), Positives = 68/180 (37%), Gaps = 21/180 (11%) Query: 41 GGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKA---VGES 97 G + L ++ E G + + + D+ ++ + V + AG+ V Sbjct: 20 KTGWIGGLLGKLCEAQGITYTYGSGRLQDRQSIVADIESVKPSHVFNAAGVTGRPNVDWC 79 Query: 98 VQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVY----GNP--QYLPLDEAHPTG 151 ++ R N+ GT+ L +I + G+ L+ ++ ++ G+P + E Sbjct: 80 ESHKVETIRTNVAGTLTLADICREKGLV-LINYATGCIFEYDSGHPLGSGIGFKEEDTPN 138 Query: 152 GCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPY 211 + Y K+K +EE++++ N LR P + + P+ + Y Sbjct: 139 FTGSFYSKTKAMVEELLKNYE------NVCTLRVRMPISSDLTN-----PRNFITKIARY 187 >3SLK-A nrPDB Length = 795 Score = 61.3 bits (147), Expect = 5e-10, Method: Composition-based stats. Identities = 39/145 (26%), Positives = 62/145 (42%), Gaps = 13/145 (8%) Query: 2 AEKVLVTGGAGYIGSHTVLEL-LEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 A VLVTGG G +G+ L +E G +V+ + S L G V Sbjct: 530 AGTVLVTGGTGALGAEVARHLVIERGVRNLVLVSRRG---PAASGAAELVAQLTAYGAEV 586 Query: 61 EFEEMDILDQGALQRLF----KKYSFMAVIHFAGLKAVGES----VQKPLDYYRVNLTGT 112 + D+ D+ L ++ ++ AV+H AG+ G S V++ R + G Sbjct: 587 SLQACDVADRETLAKVLASIPDEHPLTAVVHAAGVLDDGVSESLTVERLDQVLRPKVDGA 646 Query: 113 IQLLEIMKAHGVKNLVFSSSATVYG 137 LLE++ V ++FSS + V G Sbjct: 647 RNLLELI-DPDVALVLFSSVSGVLG 670 >6GCS-E nrPDB Length = 375 Score = 56.7 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 57/340 (16%), Positives = 124/340 (36%), Gaps = 75/340 (22%) Query: 7 VTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGR--SVEFEE 64 V G G++GS+ +L + G VV E +R ++TG V F E Sbjct: 58 VFGANGFLGSYLTAKLAKHGTTVVV-----------PYREEMAKRHLKVTGDLGVVNFLE 106 Query: 65 MDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGV 124 MD+ + ++ + V++ G + ++ YY V++ G ++ E +K H + Sbjct: 107 MDLRNLESIDEAVR--HSDIVVNLIGREYETKNFN----YYDVHVEGARRIAEAVKKHNI 160 Query: 125 KNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLR 184 + S + P + + +K E++ +D+ W ++ Sbjct: 161 ARYIHVS---AFNAEIDSP-----------SEFNHTKGLGEQVTKDIVP----WATIV-- 200 Query: 185 YFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHV 244 + G + + + + V+ N F + +HV Sbjct: 201 -------RPAPMFGREDKWFLDRMARSPCLVSA------NKFQETSNP---------VHV 238 Query: 245 VDLAKGHIAALRKL--KEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREG 302 +D+A AAL ++ + + + L ++ Q++ + + K++ + + + Sbjct: 239 IDVA----AALERICFDDSTVAQTFELYGPQKFTQKQIIDMVSETLRKEVRHIELPK--- 291 Query: 303 DVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPS 342 A Y + A + + W D+ E + QK +PS Sbjct: 292 ---ALYQAYTKATQAI-WWPTYSPDQ-VERQFLSQKIDPS 326 >3PVZ-A nrPDB Length = 399 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 43/238 (18%), Positives = 71/238 (29%), Gaps = 29/238 (12%) Query: 4 KVLVTGGAGYIGSHTVLELLEAG-YLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + LV GGAG IG E+ + V+D + L +R + Sbjct: 37 RFLVLGGAGSIGQAVTKEIFKRNPQKLHVVD---ISENNMVELVRDIRSSFGYINGDFQT 93 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKP---LDYYRVNLTGTIQLLEIM 119 +DI + + V++ + LK V S + P + VN+ T + ++ Sbjct: 94 FALDIGSIEYDAFIKADGQYDYVLNLSALKHV-RSEKDPFTLMRMIDVNVFNTDKTIQQS 152 Query: 120 KAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWN 179 G K S+ N G SK +E + + Sbjct: 153 IDAGAKKYFCVSTDKA---------------ANPVNMMGASKRIMEMFLMRKSEEIAIST 197 Query: 180 AVLLRYFNPTGAHASGCIGE----DPQGIPNNLMPYVSQVAIGRREALN--VFGNDYD 231 A G+ G P PN++ Y L +FG + D Sbjct: 198 ARFANVAFSDGSLLHGFNQRIQKNQPIVAPNDIKRYFVTPQESGELCLMSCIFGENRD 255 >3KZV-A nrPDB Length = 254 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 37/194 (19%), Positives = 60/194 (30%), Gaps = 33/194 (17%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M + +LVTG + IG V L VV G L++++E G Sbjct: 1 MGKVILVTGVSRGIGKSIVDVLFSLDKDTVVY--------GVARSEAPLKKLKEKYGDRF 52 Query: 61 EFEEMDILDQGALQRLFKKY-----SFMAVIHFAG-----LKAVGESVQKPLDYYRVNLT 110 + DI + L++L +++ AG V Y +N Sbjct: 53 FYVVGDITEDSVLKQLVNAAVKGHGKIDSLVANAGVLEPVQNVNEIDVNAWKKLYDINFF 112 Query: 111 GTIQLLEIM---KAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEM 167 + L+ I N+VF SS + YG SK + Sbjct: 113 SIVSLVGIALPELKKTNGNVVFVSSDAC------------NMYFSSWGAYGSSKAALNHF 160 Query: 168 IRDLCQADKTWNAV 181 L ++ A+ Sbjct: 161 AMTLANEERQVKAI 174 >4AVY-A nrPDB Length = 242 Score = 48.6 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 39/182 (21%), Positives = 62/182 (34%), Gaps = 23/182 (12%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 ++VLVTGG+ IG+ ++ E G V +L V + Sbjct: 12 QQVLVTGGSSGIGAAIAMQFAELGAEVV-------------ALGLDADGVHAPRHPRIRR 58 Query: 63 EEMDILDQGALQRLFKKYS-FMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 EE+DI D LQRLF+ +++ AG+ E L + + L M A Sbjct: 59 EELDITDSQRLQRLFEALPRLDVLVNNAGISRDREEYD--LATFER--VLRLNLSAAMLA 114 Query: 122 HGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNP-YGKSKFFIEEMIRDLCQADKTWNA 180 + + + N + G P Y SK I ++ R L Sbjct: 115 SQLARPLLAQRGGSILNIASM----YSTFGSADRPAYSASKGAIVQLTRSLACEYAAERI 170 Query: 181 VL 182 + Sbjct: 171 RV 172 >3U5T-A nrPDB Length = 267 Score = 48.2 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 35/186 (18%), Positives = 64/186 (34%), Gaps = 29/186 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + +VTG + IG+ L G+ V+ + G + E + E G Sbjct: 28 KVAIVTGASRGIGAAIAARLASDGFTVVI------NYAGKAAAAEEVAGKIEAAGGKALT 81 Query: 63 EEMDILDQGALQRLFKKY-----SFMAVIHFAGLKAVGESVQKPLDYYR----VNLTGTI 113 + D+ D A++RLF +++ AG+ + + + VNL GT Sbjct: 82 AQADVSDPAAVRRLFATAEEAFGGVDVLVNNAGIMPLTTIAETGDAVFDRVIAVNLKGTF 141 Query: 114 QLL-EIMKAHGV-KNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDL 171 L E + V ++ S++ V Y +K +E M L Sbjct: 142 NTLREAAQRLRVGGRIINMSTSQV------------GLLHPSYGIYAAAKAGVEAMTHVL 189 Query: 172 CQADKT 177 + + Sbjct: 190 SKELRG 195 >3EZL-A nrPDB Length = 256 Score = 48.2 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 39/207 (18%), Positives = 72/207 (34%), Gaps = 37/207 (17%) Query: 1 MAEKVL-VTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRS 59 M++++ VTGG G IG+ L + G+ V G + P ++ +++ Sbjct: 11 MSQRIAYVTGGMGGIGTSICQRLHKDGFRVV--------AGCGPNSPRRVKWLEDQKALG 62 Query: 60 VEFE--EMDILDQGALQRLFKKYS-----FMAVIHFAG----LKAVGESVQKPLDYYRVN 108 +F E ++ D + ++ F K +++ AG + + + N Sbjct: 63 FDFYASEGNVGDWDSTKQAFDKVKAEVGEIDVLVNNAGITRDVVFRKMTREDWQAVIDTN 122 Query: 109 LTG----TIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFI 164 LT T Q+++ M G ++ SS V G Y +K I Sbjct: 123 LTSLFNVTKQVIDGMVERGWGRIINISS--VNGQKGQFGQTN----------YSTAKAGI 170 Query: 165 EEMIRDLCQADKTWNAVLLRYFNPTGA 191 L Q T V + +P Sbjct: 171 HGFTMSLAQEVAT-KGVTVNTVSPGYI 196 >1QYC-A nrPDB Length = 308 Score = 47.9 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 23/130 (17%), Positives = 39/130 (30%), Gaps = 21/130 (16%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 ++L+ G GYIG H L+ G+ ++ A S E + ++ Sbjct: 4 RSRILLIGATGYIGRHVAKASLDLGHPTFLLVRESTA----SSNSEKAQLLESFKASGAN 59 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 I D +L K V S L + +++ +K Sbjct: 60 IVHGSIDDHASLVEAVKNVD------------VVISTVGSLQIESQ-----VNIIKAIKE 102 Query: 122 HGVKNLVFSS 131 G F S Sbjct: 103 VGTVKRFFPS 112 >1HE4-A nrPDB Length = 206 Score = 47.9 bits (112), Expect = 7e-06, Method: Composition-based stats. Identities = 27/141 (19%), Positives = 50/141 (35%), Gaps = 22/141 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 +K+ + G G G T+ + ++AGY V+ + G P + Sbjct: 4 KKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHV------------- 50 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 D+L + + + V+ + P G ++ MKAH Sbjct: 51 VVGDVLQAADVDKTVAGQDAVIVL------LGTRNDLSPTTVMS---EGARNIVAAMKAH 101 Query: 123 GVKNLVFSSSATVYGNPQYLP 143 GV +V +SA + +P +P Sbjct: 102 GVDKVVACTSAFLLWDPTKVP 122 >3A28-C nrPDB Length = 258 Score = 47.5 bits (111), Expect = 9e-06, Method: Composition-based stats. Identities = 30/177 (16%), Positives = 54/177 (30%), Gaps = 29/177 (16%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M++ +VTGGA IG +L G+ V D ++ E + Sbjct: 1 MSKVAMVTGGAQGIGRGISEKLAADGFDIAVAD-----LPQQEEQAAETIKLIEAADQKA 55 Query: 61 EFEEMDILDQGALQRLFKKY-----SFMAVIHFAG----LKAVGESVQKPLDYYRVNLTG 111 F +D+ D+ + F +++ AG + + + Y VN+ Sbjct: 56 VFVGLDVTDKANFDSAIDEAAEKLGGFDVLVNNAGIAQIKPLLEVTEEDLKQIYSVNVFS 115 Query: 112 TIQLLEIMK----AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFI 164 ++ GVK G A + Y +KF + Sbjct: 116 VFFGIQAASRKFDELGVK-----------GKIINAASIAAIQGFPILSAYSTTKFAV 161 >2NM0-A nrPDB Length = 253 Score = 46.7 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 40/204 (19%), Positives = 61/204 (29%), Gaps = 47/204 (23%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M+ VLVTGG IG +AG + G PE V+ Sbjct: 20 MSRSVLVTGGNRGIGLAIARAFADAGDKVAI-------TYRSGEPPEGFLAVKC------ 66 Query: 61 EFEEMDILDQGALQRLFKK----YSFMAVIHFAG-----LKAVGESVQKPLDYYRVNLTG 111 DI D +++ +K+ + + V+ + S + NLTG Sbjct: 67 -----DITDTEQVEQAYKEIEETHGPVEVLIANAGVTKDQLLMRMSEEDFTSVVETNLTG 121 Query: 112 TIQLL----EIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEM 167 T +++ M +V SS V G Y SK + Sbjct: 122 TFRVVKRANRAMLRAKKGRVVLISS--VVGLLGSAGQAN----------YAASKAGLVGF 169 Query: 168 IRDLCQADKTWNAVLLRYFNPTGA 191 R L + + N FN Sbjct: 170 ARSLARELGSRNI----TFNVVAP 189 >2QYS-A nrPDB Length = 318 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 20/82 (24%), Positives = 34/82 (41%), Gaps = 9/82 (10%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M K+L+ GG GYIG+H V L+ G+ V +++ +SL + Sbjct: 10 MKSKILIFGGTGYIGNHMVKGSLKLGHPTYVFTRPNSSKTTLLDEFQSLGAI-------- 61 Query: 61 EFEEMDILDQGALQRLFKKYSF 82 + ++ + L L KK Sbjct: 62 -IVKGELDEHEKLVELMKKVDV 82 >2V6G-A nrPDB Length = 364 Score = 45.6 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 42/300 (14%), Positives = 83/300 (27%), Gaps = 41/300 (13%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 + L+ G G IG+ +L P + R + Sbjct: 1 SSVALIVGVTGIIGNSLAE-ILPLADTPGGPWKVYGVARRTRPAWHEDNPIN-------- 51 Query: 62 FEEMDILDQGALQRLFKKYSF-MAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 + + DI D K S V H + S ++ + N +L+ + Sbjct: 52 YVQCDISDP---DDSQAKLSPLTDVTHVFYVTWANRSTEQ--ENCEANSKMFRNVLDAVI 106 Query: 121 AH---------GVKNLVFSSSATVYGNPQYL--PLDEAHPTGGCTNPYGKSKFFIEEMIR 169 + + YG + P E P N Y + +E+++ Sbjct: 107 PNCPNLKHISLQTGRKHYMGPFESYGKIESHDPPYTEDLPRLKYMNFY----YDLEDIML 162 Query: 170 DLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGND 229 + + + + R N G + + L Y + + + F Sbjct: 163 EEVEKKEGLTWSVHRPGNIFGFSPYSMM-----NLVGTLCVYAAICKHEGK--VLRFTGC 215 Query: 230 YDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASG 289 DG D +A+ HI A + +N+ G + + + + G Sbjct: 216 KAAWDGYS--DCSDADLIAEHHIWA--AVDPYAKNEAFNVSNGDVFKWKHFWKVLAEQFG 271 >2GDZ-A nrPDB Length = 267 Score = 45.2 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 25/88 (28%), Positives = 35/88 (39%), Gaps = 11/88 (12%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVID-NFHNAFRGGGSLPESLRRVQELTGRSVE 61 + LVTG A IG LL G ++D N + +L E + L Sbjct: 8 KVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALHEQFEPQKTL------ 61 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFA 89 F + D+ DQ L+ F+K V HF Sbjct: 62 FIQCDVADQQQLRDTFRKV----VDHFG 85 >1K2W-A nrPDB Length = 256 Score = 45.2 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 22/126 (17%), Positives = 47/126 (37%), Gaps = 19/126 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + L+TG A IG + G + D E+ R G + Sbjct: 6 KTALITGSARGIGRAFAEAYVREGARVAIAD----------INLEAARATAAEIGPAACA 55 Query: 63 EEMDILDQGALQRLFKKY-----SFMAVIHFAGL----KAVGESVQKPLDYYRVNLTGTI 113 +D+ DQ ++ R + S +++ A L V + + + +N++GT+ Sbjct: 56 IALDVTDQASIDRCVAELLDRWGSIDILVNNAALFDLAPIVEITRESYDRLFAINVSGTL 115 Query: 114 QLLEIM 119 +++ + Sbjct: 116 FMMQAV 121 >5U9P-A nrPDB Length = 265 Score = 44.8 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 30/180 (16%), Positives = 61/180 (33%), Gaps = 24/180 (13%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + L+TG IG L EAG V+ D +L R G + + Sbjct: 21 RRALITGSGRGIGLTLARGLAEAGAAIVIND-------RNEEKAATLARRFRDEGFAADH 73 Query: 63 EEMDILDQGALQRLFKKYS-----FMAVIHFAG-LKAVGESVQKPLDY---YRVNLTGTI 113 D+ + ++ ++ +++ AG + +P D+ RVNL G Sbjct: 74 AVFDVAEHAQVRAAIDEFEARVGAIDILVNNAGIQRRAPLDAFEPDDWHALMRVNLDGVF 133 Query: 114 QLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQ 173 + + + H + +G + ++ PY +K + + + +C Sbjct: 134 NVAQAVARHMIAR--------GHGKIINICSVQSELARPTIAPYAATKGAVRMLTKGMCA 185 >1QYD-A nrPDB Length = 313 Score = 44.8 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 25/131 (19%), Positives = 44/131 (33%), Gaps = 24/131 (18%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRS---V 60 +VL+ GG GYIG V + G+ V+ + ++ +VQ L Sbjct: 6 RVLIVGGTGYIGKRIVNASISLGHPTYVL--------FRPEVVSNIDKVQMLLYFKQLGA 57 Query: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK 120 + E + D L K+ + + L S + ++L+E +K Sbjct: 58 KLIEASLDDHQRLVDALKQVDVV----ISALAGGVLSHH---------ILEQLKLVEAIK 104 Query: 121 AHGVKNLVFSS 131 G S Sbjct: 105 EAGNIKRFLPS 115 >3OSU-A nrPDB Length = 246 Score = 44.8 bits (104), Expect = 6e-05, Method: Composition-based stats. Identities = 29/145 (20%), Positives = 55/145 (37%), Gaps = 19/145 (13%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M + LVTG + IG L+L E GY V N+ + ++ E ++ G Sbjct: 3 MTKSALVTGASRGIGRSIALQLAEEGYNVAV--NYAGSKEKAEAVVEEIKAK----GVDS 56 Query: 61 EFEEMDILDQGALQRLFKKY-----SFMAVIHFAGLK----AVGESVQKPLDYYRVNLTG 111 + ++ D ++ + K+ S +++ AG+ + Q+ D NL G Sbjct: 57 FAIQANVADADEVKAMIKEVVSQFGSLDVLVNNAGITRDNLLMRMKEQEWDDVIDTNLKG 116 Query: 112 TIQLLE----IMKAHGVKNLVFSSS 132 ++ M ++ SS Sbjct: 117 VFNCIQKATPQMLRQRSGAIINLSS 141 >3PXX-A nrPDB Length = 287 Score = 44.4 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 45/193 (23%), Positives = 68/193 (35%), Gaps = 15/193 (7%) Query: 3 EKVLVTGGA-GYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQ-----ELT 56 + VLVTGGA G SH V L E G ++ D H+ L S + E T Sbjct: 11 KVVLVTGGARGQGRSHAVK-LAEEGADIILFDICHDIETNEYPLATSRDLEEAGLEVEKT 69 Query: 57 GRSVEFEEMDILDQGALQRLFKKY-----SFMAVIHFAGLKAVG--ESVQKPLDYYRVNL 109 GR E+D+ D+ A+ R V+ AG+ +G VQ D + V+ Sbjct: 70 GRKAYTAEVDVRDRAAVSRELANAVAEFGKLDVVVANAGICPLGAHLPVQAFADAFDVDF 129 Query: 110 TGTIQLLEIMKAHGVKNLVFSSSATVYGNP-QYLPLDEAHPTGGCTNPYGKSKFFIEEMI 168 G I + + ++ +V G P P G Y +K ++ Sbjct: 130 VGVINTVHAALPYLTSGASIITTGSVAGLIAAAQPPGAGGPQGPGGAGYSYAKQLVDSYT 189 Query: 169 RDLCQADKTWNAV 181 L + Sbjct: 190 LQLAAQLAPQSIR 202 >1GEG-A nrPDB Length = 256 Score = 44.4 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 31/179 (17%), Positives = 60/179 (33%), Gaps = 35/179 (19%) Query: 1 MAEKVLVTGGAGY-IGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRS 59 M + LVTG AG IG L L++ G+ + D + +++ G Sbjct: 1 MKKVALVTG-AGQGIGKAIALRLVKDGFAVAIAD-------YNDATAKAVASEINQAGGH 52 Query: 60 VEFEEMDILDQGALQRLFKKYS-----FMAVIHFA--GLKAVGESVQKPLDY--YRVNLT 110 ++D+ D+ + ++ F +++ A ES+ + Y +N+ Sbjct: 53 AVAVKVDVSDRDQVFAAVEQARKTLGGFDVIVNNAGVAPSTPIESITPEIVDKVYNINVK 112 Query: 111 GTIQLLEIM-----KAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFI 164 G I ++ K ++ + S H Y SKF + Sbjct: 113 GVIWGIQAAVEAFKKEGHGGKIINACSQA------------GHVGNPELAVYSSSKFAV 159 >3RWB-A nrPDB Length = 247 Score = 44.0 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 32/148 (21%), Positives = 51/148 (34%), Gaps = 24/148 (16%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + LVTG A IG L G +V D E + G+ Sbjct: 7 KTALVTGAAQGIGKAIAARLAADGATVIVSD----------INAEGAKAAAASIGKKARA 56 Query: 63 EEMDILDQGALQRLFKKYS-----FMAVIHFAG-LKAVGESVQKPLDY---YRVNLTGTI 113 DI D G+++ LF + +++ A + V + VNLTGT Sbjct: 57 IAADISDPGSVKALFAEIQALTGGIDILVNNASIVPFVAWDDVDLDHWRKIIDVNLTGTF 116 Query: 114 QLLEI----MKAHG-VKNLVFSSSATVY 136 + M+A G ++ +S T + Sbjct: 117 IVTRAGTDQMRAAGKAGRVISIASNTFF 144 >6CGE-A nrPDB Length = 328 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 40/177 (22%), Positives = 70/177 (39%), Gaps = 25/177 (14%) Query: 1 MAEKV-LVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRS 59 MA V L+TG + IG H + L + + G L E+ R + G S Sbjct: 1 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPG-S 59 Query: 60 VEFEEMDILDQGAL---QRLFKKYSFMAVIHFAGLKAVG---ESVQKPLDY-YRVNLTGT 112 +E ++D+ D ++ + + ++ AGL +G + + VN+ GT Sbjct: 60 LETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGT 119 Query: 113 IQLLEI----MKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIE 165 +++L+ MK G ++ + S G LP + Y SKF +E Sbjct: 120 VRMLQAFLPDMKRRGSGRVLVTGSV---GGLMGLPF---------NDVYCASKFALE 164 >4KMS-A nrPDB Length = 249 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 46/237 (19%), Positives = 89/237 (37%), Gaps = 39/237 (16%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M+E +VTGG IG T LEL G V S ++ + ++E G Sbjct: 9 MSEIAIVTGGTRGIGKATALELKNKGLTVV---------ANFFSNYDAAKEMEEKYGIKT 59 Query: 61 EFEEMDILDQGALQRLFKKY-----SFMAV-IHFAGLK----AVGESVQKPLDYYRVNLT 110 + ++ D ++ K+ +++ ++ AG+ S Q D VNL Sbjct: 60 KCW--NVADFEECRQAVKEIEEEFKKPVSILVNNAGITKDKMLHRMSHQDWNDVINVNLN 117 Query: 111 GTIQ----LLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEE 166 ++E M+ +V SS N Q + + + Y +K I Sbjct: 118 SCFNMSSSVMEQMRNQDYGRIVNISSI----NAQAGQVGQTN--------YSAAKAGIIG 165 Query: 167 MIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREAL 223 + L + + N + + P G A+ +G P+ + ++ + + +G+ E + Sbjct: 166 FTKALARETASKN-ITVNCIAP-GYIATEMVGAVPEDVLAKIINSIPKKRLGQPEEI 220 >1A27-A nrPDB Length = 289 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 38/175 (21%), Positives = 68/175 (38%), Gaps = 24/175 (13%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 VL+TG + IG H + L + + G L E+ R + G S+E Sbjct: 2 RTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPG-SLE 60 Query: 62 FEEMDILDQGAL---QRLFKKYSFMAVIHFAGLKAVG---ESVQKPLDY-YRVNLTGTIQ 114 ++D+ D ++ + + ++ AGL +G + + VN+ GT++ Sbjct: 61 TLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVR 120 Query: 115 LLEI----MKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIE 165 +L+ MK G ++ + S G LP + Y SKF +E Sbjct: 121 MLQAFLPDMKRRGSGRVLVTGSV---GGLMGLPF---------NDVYCASKFALE 163 >6NRP-A nrPDB Length = 263 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 32/157 (20%), Positives = 65/157 (41%), Gaps = 21/157 (13%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M ++LVTG + IG L+L +AG+ V R + E + + + G++ Sbjct: 23 MTRRILVTGSSRGIGKAIALQLAKAGFDVTVH------ARSRQAEAEQVVQEIQALGQNS 76 Query: 61 EFEEMDILDQGALQRLFKK-----YSFMAVIHFAGLKAVG----ESVQKPLDYYRVNLTG 111 + D+ ++ +Q++ ++ F V+ AGL G + Q + +L G Sbjct: 77 HYLMFDVNERQTVQQILEQDVEQHGGFYGVVLNAGLTHDGAFPALTDQDWDEVISTSLDG 136 Query: 112 TIQLLE-----IMKAHGVKNLVFSSS-ATVYGNPQYL 142 +L+ ++ +V SS + + GN + Sbjct: 137 FYNVLKPLIMPMIHLRKGGRIVTLSSVSGIMGNRGQV 173 >2GAS-A nrPDB Length = 307 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 26/129 (20%), Positives = 44/129 (34%), Gaps = 20/129 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 K+L+ G G IG H V ++AG + + E + Q L V Sbjct: 3 NKILILGPTGAIGRHIVWASIKAGNPTYALVRKTITAANPETKEELIDNYQSL---GVIL 59 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 E DI D L + K+ + A + + E +++++ +K Sbjct: 60 LEGDINDHETLVKAIKQVDIVIC---AAGRLLIED--------------QVKIIKAIKEA 102 Query: 123 GVKNLVFSS 131 G F S Sbjct: 103 GNVKKFFPS 111 >3VZS-A nrPDB Length = 257 Score = 42.9 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 40/206 (19%), Positives = 69/206 (33%), Gaps = 37/206 (17%) Query: 2 AEKVL-VTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 +++ VTGG G IG+ L + G+ V G + P + +++ Sbjct: 13 TQRIAYVTGGMGGIGTAICQRLAKDGFRVV--------AGCGPNSPRREKWLEQQKALGF 64 Query: 61 EFE--EMDILDQGALQRLFKKYS-----FMAVIHFAGLK--AVGESVQKPLDY--YRVNL 109 +F E ++ D + + F K +I+ AG+ V + + NL Sbjct: 65 DFIASEGNVADWDSTKTAFDKVKSEVGEVDVLINNAGITRDVVFRKMTRADWDAVIDTNL 124 Query: 110 TG----TIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIE 165 T T Q+++ M G +V SS V G Y +K + Sbjct: 125 TSLFNVTKQVIDGMADRGWGRIVNISS--VNGQKGQFGQTN----------YSTAKAGLH 172 Query: 166 EMIRDLCQADKTWNAVLLRYFNPTGA 191 L Q T V + +P Sbjct: 173 GFTMALAQEVAT-KGVTVNTVSPGYI 197 >6CI9-A nrPDB Length = 259 Score = 42.9 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 30/176 (17%), Positives = 54/176 (30%), Gaps = 35/176 (19%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 +VTGG+ IG AG V+ R L ++ + G V Sbjct: 10 RSAIVTGGSKGIGRGIAETFANAGVDVVI------TGRNQDDLDRTVADLSGTRG-KVTA 62 Query: 63 EEMDILD----QGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYR-------VNLTG 111 D+ D + + ++ + ++ + S + VN G Sbjct: 63 VRADVTDPEDARRTVAETVSRHGGLDIV--CANAGIFPSGRLEDLTPDDIEQVLGVNFKG 120 Query: 112 TIQLLEIMKAH----GVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFF 163 T+ +++ G +V +SS T P+ + YG SK Sbjct: 121 TVYIVQAALQALTASGHGRVVVTSSIT-------GPIT----GYPGWSHYGASKAA 165 >5ITV-A nrPDB Length = 255 Score = 42.9 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 36/143 (25%), Positives = 56/143 (39%), Gaps = 22/143 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + VL+TGGA IG V L VV D + V++ + F Sbjct: 8 KTVLITGGASGIGYAAVQAFLGQQANVVVAD---------IDEAQGEAMVRKENNDRLHF 58 Query: 63 EEMDILDQGALQRLFKKY-----SFMAVIHFAGLKAVGESVQKPLDYYR----VNLTG-- 111 + DI D+ A Q + +I+ AG++ V + L + VNLTG Sbjct: 59 VQTDITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELSDWNKVLQVNLTGMF 118 Query: 112 --TIQLLEIMKAHGVKNLVFSSS 132 + L+ M A G N++ + S Sbjct: 119 LMSKHALKHMLAAGKGNIINTCS 141 >3WYE-A nrPDB Length = 256 Score = 42.5 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 44/241 (18%), Positives = 74/241 (30%), Gaps = 39/241 (16%) Query: 1 MAEKVLVTGGAGY-IGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRS 59 M + LVTG AG IG L L++ G+ + D + +++ G Sbjct: 1 MKKVALVTG-AGQGIGKAIALRLVKDGFAVAIAD-------YNDATAKAVASEINQAGGH 52 Query: 60 VEFEEMDILDQGALQRLFKKYS-----FMAVIHFAG----LKAVGESVQKPLDYYRVNL- 109 ++D+ D+ + ++ F +++ AG + + + Y VN+ Sbjct: 53 AVAVKVDVSDRDQVFAAVEQARKTLGGFDVIVNNAGIAQIKPLLEVTEEDLKQIYSVNVF 112 Query: 110 ---TGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFI-- 164 G +E K G G A + Y +KF + Sbjct: 113 SVFFGIQAAVEAFKKEGHG-----------GKIINAASIAAIQGFPILSAYSTTKFAVRG 161 Query: 165 --EEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIP--NNLMPYVSQVAIGRR 220 + RDL T N G P N Y S +A+GR Sbjct: 162 LTQTAARDLAPLGITVNGYCPGIVGTGMWEQIDAELSKINGKPIGENFKEYSSSIALGRP 221 Query: 221 E 221 Sbjct: 222 S 222 >5ILO-A nrPDB Length = 271 Score = 42.5 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 44/189 (23%), Positives = 71/189 (37%), Gaps = 34/189 (17%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + +VTGGAG IG +LL AG V I + + +L E ++ +SV Sbjct: 16 KNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQD------NLEEFVKLRAAHPTQSVMI 69 Query: 63 EEMDILDQGALQRLFKKY-----SFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQ-LL 116 +MD+ ++ ++ +++ + V++ AG + VQ+ VNL G I L Sbjct: 70 IKMDVANKKGVEATYEEIAKTFGNIDIVVNVAG-IFNDKDVQR---TLLVNLGGIINSTL 125 Query: 117 EIMKAHGVKN------LVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRD 170 + G N +V SS V G + YG +K I R Sbjct: 126 SALPYMGKDNGGKGGIVVNMSS--VVGLDPMFIIP----------VYGATKAGIINFTRC 173 Query: 171 LCQADKTWN 179 L Sbjct: 174 LANEKYYQR 182 >4B4O-A nrPDB Length = 298 Score = 42.5 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 55/342 (16%), Positives = 87/342 (25%), Gaps = 77/342 (22%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 +VLV GG G+IG+ L G+ ++ R + Sbjct: 1 MRVLVGGGTGFIGTALTQLLNARGHEVTLVSRKPGPGRITWDELAASGLPSC-------- 52 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPL----DYYRVNLTG----TIQ 114 A ++ A GE++ PL + ++ + G T Q Sbjct: 53 --------------------DAAVNLA-----GENILNPLRRWNETFQKEVLGSRLETTQ 87 Query: 115 LLEIM--KAHGVKNLVFSSSATVYGNPQ-YLPLDEAHPTGGCTNPYGKSKFFIEEMIRDL 171 LL KA + Y P DE P G S + Sbjct: 88 LLAKAITKAPQPPKAWVLVTGVAYYQPSLTAEYDEDSPGGDFDF---FSNLVTKWEAAAR 144 Query: 172 CQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYD 231 D T V+ G +G L+P+ G Sbjct: 145 LPGDSTRQVVVRS--GVVLGRGGGAMGHM-------LLPFR-------------LGLGGP 182 Query: 232 TEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKK 291 G +IH+ DLA AL + N + + + Q A G++ Sbjct: 183 IGSGHQFFPWIHIGDLAGILTHALEA---NHVHGVLNGVAPSSATNAEFAQTFGAALGRR 239 Query: 292 IPYKVVARREGDVAACYANPSLAQEELGWT--AALGLDRMCE 331 + V A + G L + Sbjct: 240 ---AFIPLPSAVVQAVFGRQRAIMLLEGQKVIPRRTLATGYQ 278 >4K6F-A nrPDB Length = 255 Score = 42.1 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 43/241 (17%), Positives = 85/241 (35%), Gaps = 37/241 (15%) Query: 1 MAEKV-LVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQ-ELTGR 58 M +++ +VTGG G +G + L +AG+ VV + + GR Sbjct: 9 MTKRIAVVTGGMGGLGEAVSIRLNDAGHRVVV-------TYSPNNTGADRWLTEMHAAGR 61 Query: 59 SVEFEEMDILDQGALQRLFKKY-----SFMAVIHFAG-LKAVGESVQKPLDY---YRVNL 109 +D+ D + Q+ +K +++ AG + + +++ R NL Sbjct: 62 EFHAYPVDVADHDSCQQCIEKIVRDVGPVDILVNNAGITRDMTLRKLDKVNWDAVIRTNL 121 Query: 110 TGTIQ----LLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIE 165 + + M G +V SS V G+ + Y +K + Sbjct: 122 DSVFNMTKPVCDGMVERGWGRIVNISS--VNGSKGSVGQTN----------YAAAKAGMH 169 Query: 166 EMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPN-NLMPYVSQVAIGRREALN 224 + L V + +P G A+ + PQ I + ++P + +G+ E + Sbjct: 170 GFTKSLALEIAR-KGVTVNTVSP-GYLATKMVTAIPQDILDTKILPQIPAGRLGKPEEVA 227 Query: 225 V 225 Sbjct: 228 A 228 >3U9L-A nrPDB Length = 324 Score = 42.1 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 42/221 (19%), Positives = 79/221 (35%), Gaps = 31/221 (14%) Query: 1 MAEKV-LVTGG-AGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGR 58 M++K+ L+TG +G+ G T L AG+ + + S E++ Sbjct: 3 MSKKIILITGASSGF-GRLTAEALAGAGHRVYA--SMRDIVGRNASNVEAIAGFARDNDV 59 Query: 59 SVEFEEMDILDQGALQRLFKKY-----SFMAVIHFAG-LKAVGESVQKPLDY---YRVNL 109 + E+D+ Q ++ R + +IH AG + P + Y +N+ Sbjct: 60 DLRTLELDVQSQVSVDRAIDQIIGEDGRIDVLIHNAGHMVFGPAEAFTPEQFAELYDINV 119 Query: 110 TGTIQL----LEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIE 165 T ++ L M+ L++ SS++ G T PY +K ++ Sbjct: 120 LSTQRVNRAALPHMRRQKHGLLIWISSSSSAGG-----------TPPYLAPYFAAKAAMD 168 Query: 166 EMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPN 206 + + W + GA SG G+P+ Sbjct: 169 AIAVQYARELSRW--GIETSIIVPGAFTSGTNHFAHSGVPD 207 >1UZM-A nrPDB Length = 247 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 39/203 (19%), Positives = 69/203 (33%), Gaps = 49/203 (24%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 ++ VLVTGG IG L G+ V A +G Sbjct: 14 VSRSVLVTGGNRGIGLAIAQRLAADGHKVAVTHRGSGAPKGLFG---------------- 57 Query: 61 EFEEMDILDQGALQRLF---KKYS-FMAVI----HFAGLKAVGESVQKP-LDYYRVNLTG 111 E+D+ D A+ R F +++ + V+ + + ++ NLTG Sbjct: 58 --VEVDVTDSDAVDRAFTAVEEHQGPVEVLVSNAGLSADAFLMRMTEEKFEKVINANLTG 115 Query: 112 TIQLLE----IMKAHGVKNLVFSSS-ATVYGNPQYLPLDEAHPTGGCTNPYGKSKF---- 162 ++ + M+ + ++F S + ++G G Y SK Sbjct: 116 AFRVAQRASRSMQRNKFGRMIFIGSVSGLWGI-------------GNQANYAASKAGVIG 162 Query: 163 FIEEMIRDLCQADKTWNAVLLRY 185 + R+L +A+ T N V Y Sbjct: 163 MARSIARELSKANVTANVVAPGY 185 >2Q4B-A nrPDB Length = 253 Score = 41.3 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 29/141 (20%), Positives = 48/141 (34%), Gaps = 25/141 (17%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 VLVTG +G G +L E G V + +G +E G + Sbjct: 6 TVLVTGASGRTGQIVYKKLKE-GSDKFVAKGLVRSAQG-----------KEKIGGEADVF 53 Query: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQ-----KPLDYYR-------VNLTG 111 DI D ++ F+ VI + + + +P + V+ G Sbjct: 54 IGDITDADSINPAFQGID-ALVILTSAVPKMKPGFDPTKGGRPEFIFEDGQYPEQVDWIG 112 Query: 112 TIQLLEIMKAHGVKNLVFSSS 132 ++ K GVK++V S Sbjct: 113 QKNQIDAAKVAGVKHIVVVGS 133 >6G2J-P nrPDB Length = 377 Score = 40.9 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 24/125 (19%), Positives = 48/125 (38%), Gaps = 14/125 (11%) Query: 7 VTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMD 66 V G G++G + V L G ++ +R LR + +L + F E D Sbjct: 58 VFGATGFLGRYVVNHLGRMGSQVII------PYRCDVYDIMHLRLMGDL--GQLTFLEWD 109 Query: 67 ILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKN 126 D+ ++++ + VI+ G + + D+ V + + + K GV+ Sbjct: 110 ARDKDSIRKAVQ--HSNVVINLIGREWETRNF----DFEDVFVNIPRAIAQASKEAGVER 163 Query: 127 LVFSS 131 + S Sbjct: 164 FIHVS 168 >3RKU-A nrPDB Length = 287 Score = 40.9 bits (94), Expect = 8e-04, Method: Composition-based stats. Identities = 33/186 (17%), Positives = 61/186 (32%), Gaps = 30/186 (16%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRV-QELTGRSVE 61 + VL+TG + IG T LE LEA + A R L E + + QE V Sbjct: 34 KTVLITGASAGIGKATALEYLEASNGDM---KLILAARRLEKLEELKKTIDQEFPNAKVH 90 Query: 62 FEEMDILDQGALQRLFKKY-----SFMAVIH-----FAGLKAVGESVQKPLDYYRVNLTG 111 ++DI ++ + +++ + + + D + N+T Sbjct: 91 VAQLDITQAEKIKPFIENLPQEFKDIDILVNNAGKALGSDRVGQIATEDIQDVFDTNVTA 150 Query: 112 TIQLLEIM----KAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEM 167 I + + + +A ++V S + Y SKF + Sbjct: 151 LINITQAVLPIFQAKNSGDIVNLGSIA------------GRDAYPTGSIYCASKFAVGAF 198 Query: 168 IRDLCQ 173 L + Sbjct: 199 TDSLRK 204 >2PNF-A nrPDB Length = 248 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 31/158 (19%), Positives = 54/158 (34%), Gaps = 20/158 (12%) Query: 6 LVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEM 65 LVTG IG +L AG ++ G + G EM Sbjct: 11 LVTGSTRGIGRAIAEKLASAGSTVII------TGTSGERAKAVAEEIANKYGVKAHGVEM 64 Query: 66 DILDQGALQRLFKKY-----SFMAVIHFAGLK----AVGESVQKPLDYYRVNLTG----T 112 ++L + ++ + F++ +++ AG+ + S+ + +VNLTG T Sbjct: 65 NLLSEESINKAFEEIYNLVDGIDILVNNAGITRDKLFLRMSLLDWEEVLKVNLTGTFLVT 124 Query: 113 IQLLEIMKAHGVKNLVFSSSATVY-GNPQYLPLDEAHP 149 L M +V SS + GN + Sbjct: 125 QNSLRKMIKQRWGRIVNISSVVGFTGNVGQVNYSTTKA 162 >5OVL-A nrPDB Length = 300 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 40/198 (20%), Positives = 65/198 (32%), Gaps = 39/198 (19%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 ++ VLVTGG IG L G+ V G P+ L VQ Sbjct: 67 VSRSVLVTGGNRGIGLAIARRLAADGHKVAV-------THRGSGAPDDLFGVQC------ 113 Query: 61 EFEEMDILDQGALQRLFKKY----SFMAV-IHFAGLK----AVGESVQKPLDYYRVNLTG 111 D+ D A+ R FK+ + V + AG+ + + ++ + NLTG Sbjct: 114 -----DVTDSAAVDRAFKEVEEHQGPVEVLVANAGISKDAFLMRMTEERFEEVINTNLTG 168 Query: 112 TIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKF----FIEEM 167 + + + +G ++ G Y +K + Sbjct: 169 AFRCAQRASRTMQRKR--------FGRIIFIGSVSGMWGIGNQANYAAAKAGLIGMARSI 220 Query: 168 IRDLCQADKTWNAVLLRY 185 R+L +A T N V Y Sbjct: 221 SRELAKAGVTANVVAPGY 238 >1YXM-A nrPDB Length = 303 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 28/133 (21%), Positives = 49/133 (36%), Gaps = 13/133 (9%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVID-NFHNAFRGGGSLPESLRRVQELTGRSVE 61 + +VTGGA IG V ELLE G V+ L +L ++ ++ Sbjct: 19 QVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPIQ 78 Query: 62 FEEMDILDQGALQRLFKK-----YSFMAVIHFAG----LKAVGESVQKPLDYYRVNLTGT 112 +I ++ + L K +++ G A S + NLTGT Sbjct: 79 C---NIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGT 135 Query: 113 IQLLEIMKAHGVK 125 + + + + +K Sbjct: 136 FYMCKAVYSSWMK 148 >4MOW-A nrPDB Length = 256 Score = 40.2 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 37/216 (17%), Positives = 73/216 (33%), Gaps = 39/216 (18%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + +VTG + IG+ L + G VV N+ ++ G ++ ++ G Sbjct: 15 KVAIVTGASKGIGAAIAKALADEGAAVVV--NYASSKAGADAVVSAITE----AGGRAVA 68 Query: 63 EEMDILDQGALQRLFKK-----------YSFMAVIHFAGLKAVGESVQKPLDYYRVNLTG 111 D+ QR+ + V FA ++A+ E + + N+ G Sbjct: 69 VGGDVSKAADAQRIVDTAIETYGRLDVLVNNSGVYEFAPIEAITE--EHYRRQFDTNVFG 126 Query: 112 TIQLLEIMKAH--GVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIR 169 + + H +++ SS T + Y +K ++ I Sbjct: 127 VLLTTQAAVKHLGEGASIINISSVV------------TSITPPASAVYSGTKGAVD-AIT 173 Query: 170 DLCQADKTWNAVLLRYFNPT-----GAHASGCIGED 200 + + + + NP G H++G IG D Sbjct: 174 GVLALELGPRKIRVNAINPGMIVTEGTHSAGIIGSD 209 >2FWM-X nrPDB Length = 250 Score = 40.2 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 33/182 (18%), Positives = 58/182 (31%), Gaps = 42/182 (23%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + V VTG IG T L +EAG D + Sbjct: 8 KNVWVTGAGKGIGYATALAFVEAGAKVTGFDQAFTQEQYP-----------------FAT 50 Query: 63 EEMDILDQGALQRL-----FKKYSFMAVIHFAGLKAVG----ESVQKPLDYYRVNLTGTI 113 E MD+ D + ++ + A+++ AG+ +G S + + VN+ G Sbjct: 51 EVMDVADAAQVAQVCQRLLAETERLDALVNAAGILRMGATDQLSKEDWQQTFAVNVGGAF 110 Query: 114 QLLEI-MKAHGVKN---LVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIR 169 L + M + +V +S H + YG SK ++ + Sbjct: 111 NLFQQTMNQFRRQRGGAIVTVASDAA------------HTPRIGMSAYGASKAALKSLAL 158 Query: 170 DL 171 + Sbjct: 159 SV 160 >5PGZ-A nrPDB Length = 276 Score = 40.2 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 34/176 (19%), Positives = 60/176 (34%), Gaps = 32/176 (18%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 +KV+VTG + IG L + G V+ R L + + R EL S + Sbjct: 19 KKVIVTGASKGIGREMAYHLSKMGAHVVL------TARSEEGLQKVVSRCLELGAASAHY 72 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESV-------QKPLDYYRVNLTGTIQL 115 + D ++ K AG G + Q L + ++ ++ Sbjct: 73 IAGTMEDMTFAEQFIVK---------AGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRV 123 Query: 116 LEIMKAHGVKNLVFSSSATV------YGNPQYLPLDEAHPTGGCTNPYGKSKFFIE 165 +E+ + V S+A + G+ + T PY SKF ++ Sbjct: 124 MEV----NFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALD 175 >5OVJ-A nrPDB Length = 256 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 40/198 (20%), Positives = 65/198 (32%), Gaps = 39/198 (19%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 ++ VLVTGG IG L G+ V G P+ L VQ Sbjct: 23 VSRSVLVTGGNRGIGLAIARRLAADGHKVAV-------THRGSGAPDDLFGVQC------ 69 Query: 61 EFEEMDILDQGALQRLFKKY----SFMAV-IHFAGLK----AVGESVQKPLDYYRVNLTG 111 D+ D A+ R FK+ + V + AG+ + + ++ + NLTG Sbjct: 70 -----DVTDSAAVDRAFKEVEEHQGPVEVLVANAGISKDAFLMRMTEERFEEVINTNLTG 124 Query: 112 TIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKF----FIEEM 167 + + + +G ++ G Y +K + Sbjct: 125 AFRCAQRASRTMQRKR--------FGRIIFIGSVSGMWGIGNQANYAAAKAGLIGMARSI 176 Query: 168 IRDLCQADKTWNAVLLRY 185 R+L +A T N V Y Sbjct: 177 SRELAKAGVTANVVAPGY 194 >4IIN-A nrPDB Length = 271 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 27/177 (15%), Positives = 57/177 (32%), Gaps = 23/177 (12%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + VL+TG + IG+ L G + +R + ++L+ E G Sbjct: 30 KNVLITGASKGIGAEIAKTLASMGLKVWI------NYRSNAEVADALKNELEEKGYKAAV 83 Query: 63 EEMDILDQGALQRLF-----KKYSFMAVIHFAGLKAVGESVQKPLDYYR----VN----L 109 + D + +++ AG+ +++ + + N Sbjct: 84 IKFDAASESDFIEAIQTIVQSDGGLSYLVNNAGVVRDKLAIKMKTEDFHHVIDNNLTSAF 143 Query: 110 TGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEE 166 G + L++M ++V +S + G + + G SK F E Sbjct: 144 IGCREALKVMSKSRFGSVVNVAS--IIGERGNMGQTNYSASKGGMI--AMSKSFAYE 196 >3OEC-A nrPDB Length = 317 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 40/211 (18%), Positives = 70/211 (33%), Gaps = 44/211 (20%) Query: 3 EKVLVTGGA-GYIGSHTVLELLEAGYLPVVID------NFHNAFRGGGSLPESLRRVQEL 55 + +TG A G G + L + G V ID N A L E++R V+E Sbjct: 47 KVAFITGAARGQ-GRTHAVRLAQDGADIVAIDLCRQQPNLDYAQGSPEELKETVRLVEE- 104 Query: 56 TGRSVEFEEMDILD----QGALQRLFKKYSFMAVIHFAGLKAVGESVQKPL--------- 102 GR + + D+ D Q + ++ + ++ + VG S Q + Sbjct: 105 QGRRIIARQADVRDLASLQAVVDEALAEFGHIDIL----VSNVGISNQGEVVSLTDQQWS 160 Query: 103 DYYRVNLTGTIQLLEIMKAHGVKN-----LVFSSSATVYGNPQYLPLDEAHPTGGCTNPY 157 D + NL G + ++ ++F SS + Y Sbjct: 161 DILQTNLIGAWHACRAVLPSMIERGQGGSVIFVSSTV------------GLRGAPGQSHY 208 Query: 158 GKSKFFIEEMIRDLCQADKTWNAVLLRYFNP 188 SK ++ ++ L N + NP Sbjct: 209 AASKHGVQGLMLSLANEVGRHNIRV-NSVNP 238 >4DBZ-A nrPDB Length = 281 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 36/171 (21%), Positives = 56/171 (32%), Gaps = 26/171 (15%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 +E LVTG IG L + G V R + V Sbjct: 26 SEVALVTGATSGIGLEIARRLGKEGLRVFVCARGEEGLRTTLKELREAGVEADGRTCDVR 85 Query: 62 FEEMDILDQGALQRLFKKYSFMAV-IHFAGLKAVGESVQKPLDYY----RVNLTG----T 112 +I + + + ++Y + V ++ AG G + + + + NLTG T Sbjct: 86 SVP-EI--EALVAAVVERYGPVDVLVNNAGRPGGGATAELADELWLDVVETNLTGVFRVT 142 Query: 113 IQLLEI--MKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSK 161 Q+L+ M G +V +S G Q L PY SK Sbjct: 143 KQVLKAGGMLERGTGRIVNIAST---GGKQGLVHA---------APYSASK 181 >4E6P-A nrPDB Length = 259 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 20/122 (16%), Positives = 42/122 (34%), Gaps = 11/122 (9%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVID-NFHNAFRGGGSLPESLRRVQELTGRSVE 61 + L+TG A IG + G + D + A + + + VQ ++ Sbjct: 9 KSALITGSARGIGRAFAEAYVREGATVAIADIDIERARQAAAEIGPAAYAVQ------MD 62 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGL----KAVGESVQKPLDYYRVNLTGTIQLLE 117 D +D + +++ A L V + + + +N+ GT+ L+ Sbjct: 63 VTRQDSIDAAIAATVEHAGGLDILVNNAALFDLAPIVEITRESYEKLFAINVAGTLFTLQ 122 Query: 118 IM 119 Sbjct: 123 AA 124 >4IIV-A nrPDB Length = 267 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 28/158 (17%), Positives = 50/158 (31%), Gaps = 23/158 (14%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M+ VLVTG + IG +L G+ V R E+L + G + Sbjct: 25 MSRSVLVTGASKGIGRAIARQLAADGFNIGVH-----YHRDAAGAQETLNAI-VANGGNG 78 Query: 61 EFEEMDILDQGALQRLFKKYSFMA-----VIHFAG----LKAVGESVQKPLDYYRVNLTG 111 D+ ++ + + + V+ AG S NL Sbjct: 79 RLLSFDVANREQCREVLEHEIAQHGAWYGVVSNAGIARDAAFPALSNDDWDAVIHTNLDS 138 Query: 112 TIQLLEIM-------KAHGVKNLVFSSSATVYGNPQYL 142 +++ + G + + SS + V GN + Sbjct: 139 FYNVIQPCIMPMIGARQGG-RIITLSSVSGVMGNRGQV 175 >4RGB-A nrPDB Length = 294 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 54/255 (21%), Positives = 86/255 (33%), Gaps = 35/255 (13%) Query: 5 VLVTGGA-GYIGSHTVLELLEAGYLPVVID-----NFHNAFRGGGSLPESLRRVQELTGR 58 V +TG A G SH V+ E G V +D + G E R+ E TG+ Sbjct: 28 VFITGAARGQGRSHAVM-CAEQGANIVGVDICEDIDIVPYKLGTYEELEETARLVEKTGQ 86 Query: 59 SVEFEEMDILDQGALQRLFKK-----YSFMAVIHFAGLKAVGESVQKPLDY----YRVNL 109 + F + D+ D+ LQ +F VI AG+ + + + L Sbjct: 87 EMLFRKADVRDKAVLQEVFDAGVEQFGHIDTVIANAGVVLTNPDERDASEALRLGLDIML 146 Query: 110 TGTIQLLEI----MKAHGV-KNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFI 164 G ++ MK G NL+ +SS + L + G T+ Y SK I Sbjct: 147 IGVWNTFQVAIPHMKERGQGGNLIATSS--------MIALLDLTDGRGGTDAYLTSKLAI 198 Query: 165 EEMIRDLCQADKTWNAVLLRYFNPTGAHAS-GCIGEDPQGIPNNLMPYVSQVAIGRREAL 223 ++R A +R + S I E+P ++ + AL Sbjct: 199 TGLVRSYAL---MLAADRIRVNGVAPTNCSTPMITENPALF--KVIEENPHLVNAMSTAL 253 Query: 224 NVFGNDYDTEDGTGV 238 F + + Sbjct: 254 PDFPMIEPRDVSNAI 268 >3DWF-A nrPDB Length = 276 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 34/178 (19%), Positives = 56/178 (31%), Gaps = 36/178 (20%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 +KV+VTG + IG L + G VV R +L + + R EL S + Sbjct: 12 KKVIVTGASKGIGREIAYHLAKMGAHVVV------TARSKEALQKVVARCLELGAASAHY 65 Query: 63 EEMDILDQGALQRLFKKYS----------FMAVIHFAGLKAVGESVQKPLDYYRVNLTGT 112 + D + + V++ GE + VN Sbjct: 66 IAGSMEDMTFAEEFVAEAGNLMGGLDMLILNHVLYNRLTFFHGE-IDNVRKSMEVNFHSF 124 Query: 113 IQLLEI-----MKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIE 165 + L M++ G +V ++V G PY SKF ++ Sbjct: 125 VVLSVAAMPMLMQSQGSIAVV----SSVAGKIT----------YPLIAPYSASKFALD 168 >5LCX-A nrPDB Length = 316 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 20/95 (21%), Positives = 40/95 (42%), Gaps = 8/95 (8%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 LVTG IG +L E G + ++ + G + L + ++ + F + Sbjct: 10 ALVTGANKGIGFEICRQLAEKGIIVILT---SRNEKRGLEARQKLLKELNVSENRLVFHQ 66 Query: 65 MDILDQGALQ--RLFKKYSF---MAVIHFAGLKAV 94 +D+ D ++ +F K F +++ AG+ V Sbjct: 67 LDVTDLASVAAVAVFIKSKFGKLDILVNNAGVSGV 101 >3WTC-A nrPDB Length = 262 Score = 38.6 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 33/196 (16%), Positives = 69/196 (35%), Gaps = 34/196 (17%) Query: 7 VTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMD 66 VTG A IG L L + G +++D +L E+ + V+ L R+V D Sbjct: 13 VTGAAQGIGKAIALRLAKDGADVILLD------VKQDTLAETAKEVEALGRRAVALT-AD 65 Query: 67 ILDQGALQRLFKKY-----SFMAVIHFAGLKAVGESVQ-KPLD---YYRVNLTGTIQLLE 117 I ++ + +++ AG+ V + +P + + +N+ G + ++ Sbjct: 66 ISNRDQFRSTLADAAKTLGGLDIMVNNAGICQVKPILDIEPAEIEKIFSINVQGVLWGMQ 125 Query: 118 IM----KAHGVK-NLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLC 172 K G K ++ + S H Y +KF + + Sbjct: 126 AAATLFKEKGTKGKIINACSIA------------GHEGYPLLGAYSATKFAV-RALTQSA 172 Query: 173 QADKTWNAVLLRYFNP 188 + + + + + P Sbjct: 173 AKELASSGITVNSYCP 188 >3WOH-A nrPDB Length = 251 Score = 38.6 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 25/149 (16%), Positives = 52/149 (34%), Gaps = 20/149 (13%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + LVTGG+ +G L L G ++ + + + R+ G + Sbjct: 12 KVALVTGGSRGLGRAMALRLARDGAAVAIV--YVSDDSSAKETQGEIERL----GGTARS 65 Query: 63 EEMDILDQGALQRLFKKY-----SFMAVIHFAGLK--AVGESVQKPLDY--YRVNLTGTI 113 D+ D + R K +++ AG+ + S++ NL G Sbjct: 66 YRCDVSDAEQVTRCVKAVTADLGPVDILVNNAGIIRDGLAASIKDEDYDAVMNTNLKGAF 125 Query: 114 QLLEIMKAHGVKN----LVFSSS-ATVYG 137 ++ ++ ++ SS + V+G Sbjct: 126 LFIKACYFGFIRKRSGSIINISSVSGVFG 154 >5VT6-A nrPDB Length = 269 Score = 38.6 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 36/238 (15%), Positives = 72/238 (30%), Gaps = 33/238 (13%) Query: 2 AEKV-LVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 A++V VTGG G +G+ L +AG V + + + GR Sbjct: 24 AKRVAFVTGGMGGLGAAISRRLHDAGMAVAV------SHSERNDHVSTWLMHERDAGRDF 77 Query: 61 EFEEMDILDQGALQRLFKKY-----SFMAVIHFAG----LKAVGESVQKPLDYYRVNLTG 111 + +D+ D + +R +K +I+ AG + + R +L Sbjct: 78 KAYAVDVADFESCERCAEKVLADFGKVDVLINNAGITRDATFMKMTKGDWDAVMRTDLDA 137 Query: 112 TIQL----LEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEM 167 + + M +V S V G+ Y +K I Sbjct: 138 MFNVTKQFIAGMVERRFGRIVNIGS--VNGSRGAFGQAN----------YASAKAGIHGF 185 Query: 168 IRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNV 225 + L + + +P + + ++P + +GR + + Sbjct: 186 TKTLALET-AKRGITVNTVSPGYLATAMVEAVPQDVLEAKILPQIPVGRLGRPDEVAA 242 >5F5N-A nrPDB Length = 289 Score = 38.6 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 19/79 (24%), Positives = 25/79 (31%), Gaps = 11/79 (13%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 +LVTG G G TV LL G R P + + L V Sbjct: 2 RTILVTGATGTQGGATVRALLARGRPV----------RALVRDPGT-DAARALAAAGVSL 50 Query: 63 EEMDILDQGALQRLFKKYS 81 D+ DQ +L+ Sbjct: 51 VTGDLNDQASLRAAMADVH 69 >2NWQ-A nrPDB Length = 272 Score = 38.2 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 37/203 (18%), Positives = 65/203 (32%), Gaps = 40/203 (19%) Query: 1 MAEKVLVTGGA-GYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRS 59 M+ + +TG G+ G EAG+ V+ + + RV LT Sbjct: 20 MSSTLFITGATSGF-GEACARRFAEAGWSLVLTGRREERLQALAGELSAKTRVLPLT--- 75 Query: 60 VEFEEMDILDQGALQRLFKKYSFM-----AVIHFAGLKAVGE-----SVQKPLDYYRVNL 109 +D+ D+ A+ +I+ AGL + + N+ Sbjct: 76 -----LDVRDRAAMSAAVDNLPEEFATLRGLINNAGLALGTDPAQSCDLDDWDTMVDTNI 130 Query: 110 TGTIQ----LLEIMKAHGVK-NLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFI 164 G + LL + AHG ++V S ++ YG +K F+ Sbjct: 131 KGLLYSTRLLLPRLIAHGAGASIVNLGSVA------------GKWPYPGSHVYGGTKAFV 178 Query: 165 EEMIRDLCQADKTWNAVLLRYFN 187 E+ +L +R N Sbjct: 179 EQFSLNLR---CDLQGTGVRVTN 198 >3UN1-A nrPDB Length = 260 Score = 38.2 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 35/217 (16%), Positives = 70/217 (32%), Gaps = 38/217 (17%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + V++TG + IG+ V + Y V + R ++ + Sbjct: 29 KVVVITGASQGIGAGLVRAYRDRNYRVV----------------ATSRSIKPSADPDIHT 72 Query: 63 EEMDILDQGALQRLFKK-----YSFMAVIHFA----GLKAVGESVQKPLDYYRVNLTGTI 113 DI R+ ++ ++++ A V + + VN+ G Sbjct: 73 VAGDISKPETADRIVREGIERFGRIDSLVNNAGVFLAKPFVEMTQEDYDHNLGVNVAGFF 132 Query: 114 QLLEI----MKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIR 169 + + M G ++V +++ V +P A T G N ++ E R Sbjct: 133 HITQRAAAEMLKQGSGHIVSITTSLVDQPMVGMPSALASLTKGGLN--AVTRSLAMEFSR 190 Query: 170 DLCQADKTWNAVLLRYFNP-------TGAHASGCIGE 199 + + V+ +P G H G +GE Sbjct: 191 SGVRVNAVSPGVIKTPMHPAETHSTLAGLHPVGRMGE 227 >5GUP-L nrPDB Length = 377 Score = 38.2 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 52/293 (17%), Positives = 105/293 (35%), Gaps = 58/293 (19%) Query: 7 VTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMD 66 V G G++G + V L G +V +R LR + +L + F E + Sbjct: 58 VFGATGFLGRYVVNHLGRMGSQVIV------PYRCEPYDTMHLRPMGDL--GQIIFMEWN 109 Query: 67 ILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQ-KPLDYYRVNLTGTIQLLEIMKAHGVK 125 D+ +++++ + VI+ VG + K D+ V + + ++ K GV+ Sbjct: 110 GKDKDSIRKVVE--HSNVVINL-----VGREWETKNFDFEDVFVKIPHAIAQVSKEAGVE 162 Query: 126 NLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRY 185 L+ S +L D P + Y +SK E+ +R Sbjct: 163 KLIHIS---------HLNADIKSP-----SRYLRSKAVGEKEVRAAFPEA---------- 198 Query: 186 FNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVV 245 T S G + + + Y + + L G + + +++V Sbjct: 199 ---TIIKPSDIFGREDR-----FLNYFASMRWFGGVPLISLGKETVKQP-------VYIV 243 Query: 246 DLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKK-IPYKVV 297 D++KG I A++ + + Y + +VQ + + + +PY + Sbjct: 244 DVSKGIINAIKDPDAKGKTFAFV--GPNRYLLFDLVQYIFAVAYRPFLPYPLP 294 >1AE1-A nrPDB Length = 273 Score = 37.8 bits (86), Expect = 0.006, Method: Composition-based stats. Identities = 40/187 (21%), Positives = 58/187 (31%), Gaps = 39/187 (20%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 LVTGG+ IG V EL G + R L E L +E G +VE Sbjct: 22 TTALVTGGSKGIGYAIVEELAGLGA------RVYTCSRNEKELDECLEIWRE-KGLNVEG 74 Query: 63 EEMDILDQGALQRLFKKYSFM-------------AVIHFAGLKAVGESVQKPLDYYRVNL 109 D+L + +L + + + VIH + N Sbjct: 75 SVCDLLSRTERDKLMQTVAHVFDGKLNILVNNAGVVIHKEAKDFTEKDYN---IIMGTNF 131 Query: 110 TGTIQLLEIM----KAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIE 165 L +I KA N++F SS + + Y SK I Sbjct: 132 EAAYHLSQIAYPLLKASQNGNVIFLSSIAGFSAL------------PSVSLYSASKGAIN 179 Query: 166 EMIRDLC 172 +M + L Sbjct: 180 QMTKSLA 186 >3F9I-A nrPDB Length = 249 Score = 37.5 bits (85), Expect = 0.009, Method: Composition-based stats. Identities = 22/140 (15%), Positives = 48/140 (34%), Gaps = 19/140 (13%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + L+TG + IGS L + G ++ GS E L+ + + Sbjct: 15 KTSLITGASSGIGSAIARLLHKLGSKVII----------SGSNEEKLKSLGNALKDNYTI 64 Query: 63 EEMDILDQGALQRLFKKYS-FMAVIHFAGLKAVGESVQKPLDYYRV--------NLTGTI 113 E ++ ++ L K S ++ AG+ + +++ + N Sbjct: 65 EVCNLANKEECSNLISKTSNLDILVCNAGITSDTLAIRMKDQDFDKVIDINLKANFILNR 124 Query: 114 QLLEIMKAHGVKNLVFSSSA 133 + ++ M ++ SS Sbjct: 125 EAIKKMIQKRYGRIINISSI 144 >2BC1-A nrPDB Length = 490 Score = 37.5 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 20/112 (17%), Positives = 38/112 (33%), Gaps = 8/112 (7%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 ++V V G AGYIG G V+ID G + + + ++ Sbjct: 195 KRVAVVG-AGYIGVELAEAFQRKGKEVVLIDVVDTCLAGYYDRDLTDLMAKNMEEHGIQL 253 Query: 63 EEM----DILDQGALQRLFK---KYSFMAVIHFAGLKAVGESVQKPLDYYRV 107 ++ G ++++ +Y VI G + +D +R Sbjct: 254 AFGETVKEVAGNGKVEKIITDKNEYDVDMVILAVGFRPNTTLGNGKIDLFRN 305 >1OOE-A nrPDB Length = 236 Score = 37.1 bits (84), Expect = 0.010, Method: Composition-based stats. Identities = 35/178 (19%), Positives = 51/178 (28%), Gaps = 15/178 (8%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 + KV+V GG G +GS + + GY + ID N L + + E Sbjct: 3 SGKVIVYGGKGALGSAILEFFKKNGYTVLNIDLSANDQADSNILVDGNKNWTEQ------ 56 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 E IL+Q + V AG A G S +L + A Sbjct: 57 --EQSILEQT--ASSLQGSQVDGVFCVAGGWAGG-SASSKDFVKNADLMIKQSVWSSAIA 111 Query: 122 HGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWN 179 + G Q A YG +K + + L D Sbjct: 112 AKLATTHLKPG----GLLQLTGAAAAMGPTPSMIGYGMAKAAVHHLTSSLAAKDSGLP 165 >3GRP-A nrPDB Length = 266 Score = 37.1 bits (84), Expect = 0.012, Method: Composition-based stats. Identities = 32/154 (20%), Positives = 56/154 (36%), Gaps = 24/154 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 K LVTG G IG G + + G+ + L+ + G+ V Sbjct: 28 RKALVTGATGGIGEAIARCFHAQGAIVGLH----------GTREDKLKEIAADLGKDVFV 77 Query: 63 EEMDILDQGALQRLF-----KKYSFMAVIHFAGLK----AVGESVQKPLDYYRVNLTG-- 111 ++ D+ ++++L + +++ AG+ V Q D VNLT Sbjct: 78 FSANLSDRKSIKQLAEVAEREMEGIDILVNNAGITRDGLFVRMQDQDWDDVLAVNLTAAS 137 Query: 112 --TIQLLEIMKAHGVKNLVFSSSAT-VYGNPQYL 142 T +L+ M ++ +S V GNP Sbjct: 138 TLTRELIHSMMRRRYGRIINITSIVGVVGNPGQT 171 >3OIC-A nrPDB Length = 258 Score = 37.1 bits (84), Expect = 0.012, Method: Composition-based stats. Identities = 31/191 (16%), Positives = 65/191 (34%), Gaps = 31/191 (16%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 LVTG + +G + L E GY V+ N+ + + E + ++ G V + Sbjct: 7 ALVTGSSRGVGKAAAIRLAENGYNIVI--NYARSKKAALETAEEIEKL----GVKVLVVK 60 Query: 65 MDILDQGALQRLFKKYSF-----MAVIHFAGLKAVGESVQKPL----DYYRVNLTGTI-Q 114 ++ ++ +F++ ++ A + ++ +N + Sbjct: 61 ANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELEETHWDWTMNINAKALLFC 120 Query: 115 LLEIMK---AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDL 171 E K +G ++V SS + E + T G SK +E + R L Sbjct: 121 AQEAAKLMEKNGGGHIVSISS------LGSIRYLENYTTV------GVSKAALEALTRYL 168 Query: 172 CQADKTWNAVL 182 ++ Sbjct: 169 AVELSPKQIIV 179 >2UVD-A nrPDB Length = 246 Score = 37.1 bits (84), Expect = 0.012, Method: Composition-based stats. Identities = 27/153 (17%), Positives = 56/153 (36%), Gaps = 20/153 (13%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + LVTG + IG ++L + G VV N+ + + + ++++ G Sbjct: 5 KVALVTGASRGIGRAIAIDLAKQGANVVV--NYAGNEQKANEVVDEIKKL----GSDAIA 58 Query: 63 EEMDILDQGALQRLFKK-----YSFMAVIHFAGLKAVGESVQKPLDYYR----VNLTG-- 111 D+ + + + K+ +++ AG+ ++ + + NL G Sbjct: 59 VRADVANAEDVTNMVKQTVDVFGQVDILVNNAGVTKDNLLMRMKEEEWDTVINTNLKGVF 118 Query: 112 --TIQLLEIMKAHGVKNLVFSSSAT-VYGNPQY 141 T + M +V +S V GNP Sbjct: 119 LCTKAVSRFMMRQRHGRIVNIASVVGVTGNPGQ 151 >6D9T-A nrPDB Length = 400 Score = 37.1 bits (84), Expect = 0.012, Method: Composition-based stats. Identities = 19/118 (16%), Positives = 44/118 (37%), Gaps = 6/118 (5%) Query: 3 EKVLVT-----GGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTG 57 K+ +T GG+G I + ++L E G+ I + +V+ Sbjct: 21 MKIGITCYPSMGGSGIIATELGIKLAERGHEVHFITSNIPFRIRKPLPNMIFHQVEVNQY 80 Query: 58 RSVEFEEMDILDQGALQRLFKKYSFMAV-IHFAGLKAVGESVQKPLDYYRVNLTGTIQ 114 ++ DI + + K+Y + +H+A A+ + + + + + T+ Sbjct: 81 AVFQYPPYDITLSTKIAEVIKEYDLDLLHMHYAVPHAICGILAREMSGKDIKIMTTLH 138 >3OML-A nrPDB Length = 613 Score = 37.1 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 55/323 (17%), Positives = 105/323 (32%), Gaps = 56/323 (17%) Query: 5 VLVTG-GAGYIGSHTVLELLEAGYLPVVID--NFHNAFRGGGSLPESLRRVQELTGRSVE 61 +VTG GAG +G L E G VV D H+ + + G Sbjct: 22 AVVTGAGAG-LGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRKAGGEAV 80 Query: 62 FEEMDILDQGALQRLFKKY--SFMAVIHFAGL----KAVGESVQKPLDYYRVNLTGTIQL 115 + ++D + K +++ AG+ V S Q V+L G+ + Sbjct: 81 ADYNSVIDGAKVIETAIKAFGRVDILVNNAGILRDRSLVKTSEQDWNLVNDVHLKGSFKC 140 Query: 116 LEI----MKAHGVKNLVFSSS-ATVYGNPQY----------LPLDEAHPTGGCTN----- 155 + MK ++ +SS + +YGN + L G N Sbjct: 141 TQAAFPYMKKQNYGRIIMTSSNSGIYGNFGQVNYTAAKMGLIGLANTVAIEGARNNVLCN 200 Query: 156 ---PYGKSKFFIEEMIRD--LCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMP 210 P S+ E ++ D + A ++ Y +G E G L Sbjct: 201 VIVPTAASR-MTEGILPDILFNELKPKLIAPVVAYLCHESCEDNGSYIESAAGWATKL-- 257 Query: 211 YVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLG 270 + G+ L +D T + +V D+ + + + + Sbjct: 258 ---HMVRGKGAVLRPSLDDPVTIE--------YVKDV----WSNVTDMSKAKHLGAIAEA 302 Query: 271 TGTGYSVLQMVQAMEKASGKKIP 293 +G ++L++++ +++ G I Sbjct: 303 SG---TLLEVLEKLKEGGGDAIE 322 >3O4R-A nrPDB Length = 261 Score = 37.1 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 28/175 (16%), Positives = 52/175 (29%), Gaps = 28/175 (16%) Query: 1 MAEKV-LVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRS 59 +A KV LVT IG L + G VV + + + + + L+ Sbjct: 13 LANKVALVTASTDGIGFAIARRLAQDGAHVVV----SSRKQQNVDQAVATLQGEGLSVTG 68 Query: 60 VEFEEMDILDQGALQRLFKKYS--FMAVIHFAGL-----KAVGESVQKPLDYYRVNL--- 109 D+ L K ++ A + + + + +N+ Sbjct: 69 TVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAP 128 Query: 110 -TGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFF 163 T ++ M+ G ++V SS + +PY SK Sbjct: 129 ALMTKAVVPEMEKRGGGSVVIVSSIAAFS------------PSPGFSPYNVSKTA 171 >3ZV3-A nrPDB Length = 281 Score = 36.7 bits (83), Expect = 0.014, Method: Composition-based stats. Identities = 33/154 (21%), Positives = 54/154 (35%), Gaps = 28/154 (18%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 E L+TGGA +G V + G V+D E LR ++ G + Sbjct: 6 EVALITGGASGLGRALVDRFVAEGARVAVLDK----------SAERLRELEVAHGGNAVG 55 Query: 63 EEMDILDQGALQRLFKKY-----SFMAVIHFA-------GLKAVGESVQKPL--DYYRVN 108 D+ +R ++ +I A L + E D + VN Sbjct: 56 VVGDVRSLQDQKRAAERCLAAFGKIDTLIPNAGIWDYSTALADLPEDKIDAAFDDIFHVN 115 Query: 109 LTGTIQLLEIMKAHGVK---NLVFS-SSATVYGN 138 + G I ++ V ++VF+ S+A Y N Sbjct: 116 VKGYIHAVKACLPALVSSRGSVVFTISNAGFYPN 149 >5IZ4-A nrPDB Length = 271 Score = 36.7 bits (83), Expect = 0.014, Method: Composition-based stats. Identities = 36/143 (25%), Positives = 54/143 (37%), Gaps = 18/143 (12%) Query: 7 VTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMD 66 +TG A IG+ T L +AG+ + NF ++ R S E+L R + + Sbjct: 19 ITGSASGIGAATALRFAQAGWSVAI-GNFDDSTRDAASTVEALCRDAGAQTLIFDADVGK 77 Query: 67 ILDQGALQRLFKKY--SFMAVIHFAGLKAV--GESVQKPLDY-----YRVNLTGTIQ--- 114 D + A+I+ AG V + + D+ YRVNL G Q Sbjct: 78 DADCRHAVDMVASRWQRIDALINCAGTTRVIPHNAFDQIDDFEFERVYRVNLIGLYQMTR 137 Query: 115 -----LLEIMKAHGVKNLVFSSS 132 L E A ++V SS Sbjct: 138 AAVPLLRESASATRSTSVVNVSS 160 >1BDB-A nrPDB Length = 277 Score = 36.7 bits (83), Expect = 0.016, Method: Composition-based stats. Identities = 60/299 (20%), Positives = 103/299 (34%), Gaps = 47/299 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 E VL+TGGA +G V + G V+D E L ++ G +V Sbjct: 6 EAVLITGGASGLGRALVDRFVAEGAKVAVLDK----------SAERLAELETDHGDNVLG 55 Query: 63 EEMDILDQGALQRLFKKY-----SFMAVIHFA-------GLKAVGESVQKPL--DYYRVN 108 D+ ++ + +I A L + E + + +N Sbjct: 56 IVGDVRSLEDQKQAASRCVARFGKIDTLIPNAGIWDYSTALVDLPEESLDAAFDEVFHIN 115 Query: 109 LTGTIQLLEIMKAHGV---KNLVFS-SSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFI 164 + G I ++ V N++F+ S+A Y N GG Y +K I Sbjct: 116 VKGYIHAVKACLPALVASRGNVIFTISNAGFYPN-----------GGGPL--YTAAKHAI 162 Query: 165 EEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALN 224 ++R+L A + V + G + S G G+ + + V +A + L Sbjct: 163 VGLVREL--AFELAPYVRVNGVGSGGIN-SDLRGPSSLGMGSKAISTVP-LADMLKSVLP 218 Query: 225 VFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQA 283 + G + E+ TG + A AL G R + G G G +L+ + Sbjct: 219 I-GRMPEVEEYTGAYVFFATRGDAAPATGALLNYDGGLGVRGFFSGAG-GNDLLEQLNI 275 >3RSH-A nrPDB Length = 251 Score = 36.3 bits (82), Expect = 0.018, Method: Composition-based stats. Identities = 30/196 (15%), Positives = 61/196 (31%), Gaps = 39/196 (19%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + LVTG + IG L E G + G + + + + G + + Sbjct: 13 KVALVTGASRGIGKAIAELLAERGAKVI----------GTATSESGAQAISDYLGDNGKG 62 Query: 63 EEMDILDQGALQRLFKKY-----SFMAVIHFAGLK----AVGESVQKPLDYYRVNLTGTI 113 +++ + +++ + K +++ AG+ + ++ D NLT Sbjct: 63 MALNVTNPESIEAVLKAITDEFGGVDILVNNAGITRDNLLMRMKEEEWSDIMETNLTSIF 122 Query: 114 QL----LEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKF----FIE 165 +L L M ++ S Y +K F + Sbjct: 123 RLSKAVLRGMMKKRQGRIINVGSVV------------GTMGNAGQANYAAAKAGVIGFTK 170 Query: 166 EMIRDLCQADKTWNAV 181 M R++ T N V Sbjct: 171 SMAREVASRGVTVNTV 186 >2HRB-A nrPDB Length = 274 Score = 36.3 bits (82), Expect = 0.020, Method: Composition-based stats. Identities = 45/239 (18%), Positives = 66/239 (27%), Gaps = 60/239 (25%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEA--GYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRS 59 + LVTG IG EL G + + + L + G S Sbjct: 2 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQL--------QAEGLS 53 Query: 60 VEFEEMDILDQ---GALQRLFKKY--SFMAVIHFAGLKAVGESVQKPLDY-------YRV 107 F ++DI D AL+ +K +++ A V P+ + + Sbjct: 54 PRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAA---VAFKSDDPMPFDIKAEMTLKT 110 Query: 108 NLTGTIQ----LLEIMKAHGVKNLVFSSSATV---------------------------- 135 N T LL IMK HG +V SS Sbjct: 111 NFFATRNMCNELLPIMKPHG--RVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDL 168 Query: 136 YGNPQYLPLDEAHPTGG-CTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHA 193 +E H G +PYG SK + + R L + N Sbjct: 169 MKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGP 227 >3O26-A nrPDB Length = 311 Score = 35.9 bits (81), Expect = 0.029, Method: Composition-based stats. Identities = 19/95 (20%), Positives = 38/95 (40%), Gaps = 12/95 (12%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 +VTGG IG +L G + V+ R E++ +++ +V F + Sbjct: 15 AVVTGGNKGIGFEICKQLSSNGIMVVL------TCRDVTKGHEAVEKLKNSNHENVVFHQ 68 Query: 65 MDILDQ----GALQRLFKKY--SFMAVIHFAGLKA 93 +D+ D +L K + +++ AG+ Sbjct: 69 LDVTDPIATMSSLADFIKTHFGKLDILVNNAGVAG 103 >3ORF-A nrPDB Length = 251 Score = 35.5 bits (80), Expect = 0.030, Method: Composition-based stats. Identities = 10/33 (30%), Positives = 18/33 (54%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVID 33 M++ +LV GG+G +G+ V + + ID Sbjct: 21 MSKNILVLGGSGALGAEVVKFFKSKSWNTISID 53 >3KYB-A nrPDB Length = 390 Score = 35.5 bits (80), Expect = 0.032, Method: Composition-based stats. Identities = 13/60 (21%), Positives = 26/60 (43%), Gaps = 2/60 (3%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNF-HNAFRGGGSLPESLRRVQELTGRSV 60 ++K+L+ G AG+ G+ +L E G+ +ID H + + + G + Sbjct: 3 SKKILIVG-AGFSGAVIGRQLAEKGHQVHIIDQRDHIGGNSYDARDSETNVMVHVYGPHI 61 >3EMK-A nrPDB Length = 246 Score = 35.5 bits (80), Expect = 0.035, Method: Composition-based stats. Identities = 26/122 (21%), Positives = 44/122 (36%), Gaps = 19/122 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 K LVTG G +G L G + + G+ E L+ + G + Sbjct: 8 RKALVTGATGGLGEAIARALHAQGAIVGLH----------GTREEKLKELAAELGERIFV 57 Query: 63 EEMDILDQGALQRLFKKY-----SFMAVIHFAGLK----AVGESVQKPLDYYRVNLTGTI 113 ++ D+ A++ L +K +++ AG+ V S + VNLT Sbjct: 58 FPANLSDREAVKALGQKAEEEMGGVDILVNNAGITRDGLFVRMSDEDWDAVLTVNLTSVF 117 Query: 114 QL 115 L Sbjct: 118 NL 119 >2PH3-A nrPDB Length = 245 Score = 35.5 bits (80), Expect = 0.036, Method: Composition-based stats. Identities = 39/237 (16%), Positives = 67/237 (28%), Gaps = 38/237 (16%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 K L+TG + IG L L E G F A G + ++ +E R Sbjct: 2 RKALITGASRGIGRAIALRLAEDG--------FALAIHYGQNREKAEEVAEEARRRGSPL 53 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLL------ 116 + L + + A++H A G LD N T L Sbjct: 54 VAV------LGANLLEAEAATALVHQAAEVLGG------LDTLVNNAGITRDTLLVRMKD 101 Query: 117 ---EIMKAHGVKNLVFSSSATV-------YGNPQYLPLDEAHPTGGCTNPYGKSKFFIEE 166 E + + + ++ V +G + Y SK + Sbjct: 102 EDWEAVLEANLSAVFRTTREAVKLMMKARFGRIVNITSVVGILGNPGQANYVASKAGLIG 161 Query: 167 MIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREAL 223 R + + + + P G + PQ + + + GR E + Sbjct: 162 FTRAVAKEY-AQRGITVNAVAP-GFIETEMTERLPQEVKEAYLKQIPAGRFGRPEEV 216 >4CQL-A nrPDB Length = 261 Score = 35.5 bits (80), Expect = 0.037, Method: Composition-based stats. Identities = 42/254 (16%), Positives = 74/254 (29%), Gaps = 34/254 (13%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 LVTG IG + L G D A + L + + + Sbjct: 14 ALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAFQ 73 Query: 65 MDILDQGALQRLFKKYS------FMAVIHFAGLK----AVGESVQKPLDYYRVNLTGTIQ 114 D+ + A + L ++ V+ AG+ + S VNL GT Sbjct: 74 ADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFL 133 Query: 115 LLEIMKAHGVKN-----LVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIR 169 + + V N ++ SS G + Y SK + + Sbjct: 134 VTQAAAQALVSNGCRGSIINISSIV--GKVGNVGQTN----------YAASKAGV-IGLT 180 Query: 170 DLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALN----- 224 + + + P G A+ + PQ + + + + +G E + Sbjct: 181 QTAARELGRHGIRCNSVLP-GFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAF 239 Query: 225 VFGNDYDTEDGTGV 238 + D GT V Sbjct: 240 LASEDSGYITGTSV 253 >1H5Q-A nrPDB Length = 265 Score = 35.5 bits (80), Expect = 0.037, Method: Composition-based stats. Identities = 40/248 (16%), Positives = 77/248 (31%), Gaps = 21/248 (8%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + ++VTGG IG + AG VI +R E +V + G + Sbjct: 15 KTIIVTGGNRGIGLAFTRAVAAAGANVAVI------YRSAADAVEVTEKVGKEFGVKTKA 68 Query: 63 EEMDILDQGALQRLFKKYSFM-----AVIHFAGLKAVGESV----QKPLDYYRVNLTGTI 113 + D+ + + + ++ +I AG+ V + + Y VN+ G Sbjct: 69 YQCDVSNTDIVTKTIQQIDADLGPISGLIANAGVSVVKPATELTHEDFAFVYDVNVFGVF 128 Query: 114 QLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNP-YGKSKFFIEEMI---- 168 + ++ S V + ++++ G T Y SK ++ Sbjct: 129 NTCRAVAKLWLQKQ-QKGSIVVTSSMSSQIINQSSLNGSLTQVFYNSSKAACSNLVKGLA 187 Query: 169 RDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGN 228 + A NA+ Y N D Q L + + + L + + Sbjct: 188 AEWASAGIRVNALSPGYVNTDQTAHMDKKIRDHQASNIPLNRFAQPEEMTGQAILLLSDH 247 Query: 229 DYDTEDGT 236 G Sbjct: 248 ATYMTGGE 255 >5CDY-A nrPDB Length = 244 Score = 35.1 bits (79), Expect = 0.041, Method: Composition-based stats. Identities = 28/190 (14%), Positives = 60/190 (31%), Gaps = 31/190 (16%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 LVTG + IG L+E G + G + + + G + + Sbjct: 8 ALVTGASRGIGRAIAELLVERGACVI----------GTATSEKGAEAISAYLGENGKGLM 57 Query: 65 MDILDQGALQRLFKKYS-----FMAVIHFAGLK----AVGESVQKPLDYYRVNLTGTIQL 115 ++++D ++ + +++ AG+ + + D NLT +L Sbjct: 58 LNVVDPTSIDTVLATIRAEFGEVDILVNNAGITRDNLLMRMKDDEWQDIIDTNLTSVFRL 117 Query: 116 LEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKF----FIEEMIRDL 171 + + +K +G + Y +K F + + R++ Sbjct: 118 SKAVMRAMMKKR--------FGRIITIGSVVGTMGNAGQVNYAAAKAGVIGFSKSLAREV 169 Query: 172 CQADKTWNAV 181 T N V Sbjct: 170 ASRGITVNVV 179 >2Q2Q-A nrPDB Length = 255 Score = 35.1 bits (79), Expect = 0.044, Method: Composition-based stats. Identities = 31/143 (21%), Positives = 52/143 (36%), Gaps = 22/143 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + LVTG IG L AG V+ G G +L + ++V Sbjct: 5 KTALVTGSTSGIGLGIAQVLARAGANIVL--------NGFGDPAPALAEIARHGVKAVH- 55 Query: 63 EEMDILDQGALQRLF-----KKYSFMAVIHFAGLKAVGESVQKPLDYYRV----N----L 109 D+ D ++ LF + +++ AG++ V Q PL+ + N Sbjct: 56 HPADLSDVAQIEALFALAEREFGGVDILVNNAGIQHVAPVEQFPLESWDKIIALNLSAVF 115 Query: 110 TGTIQLLEIMKAHGVKNLVFSSS 132 GT L M+A ++ +S Sbjct: 116 HGTRLALPGMRARNWGRIINIAS 138 >3V8B-A nrPDB Length = 283 Score = 35.1 bits (79), Expect = 0.046, Method: Composition-based stats. Identities = 30/143 (20%), Positives = 49/143 (34%), Gaps = 21/143 (14%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 L+TG IG T L L G + R + E + G+++ E Sbjct: 31 ALITGAGSGIGRATALALAADGVTVGALG------RTRTEVEEVADEIVGAGGQAIAL-E 83 Query: 65 MDILDQGALQRLFKKY-----SFMAVIHFAGLKAVGESVQKPLDY-----YRVNLTGTIQ 114 D+ D+ ++ + V+ AG+ V + + VNL GT Sbjct: 84 ADVSDELQMRNAVRDLVLKFGHLDIVVANAGINGVWAPIDDLKPFEWDETIAVNLRGTFL 143 Query: 115 LLEI----MKAHGVKNLVFSSSA 133 L + +K G +V SS Sbjct: 144 TLHLTVPYLKQRGGGAIVVVSSI 166 >2ZCU-A nrPDB Length = 286 Score = 34.8 bits (78), Expect = 0.054, Method: Composition-based stats. Identities = 30/180 (16%), Positives = 58/180 (32%), Gaps = 45/180 (25%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 + +TG G +G + + L++ ++ + + Q L + + + Sbjct: 2 IAITGATGQLGHYVIESLMK-----------TVPASQIVAIVRNPAKAQALAAQGITVRQ 50 Query: 65 MDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGV 124 D D+ AL + + +I VG+ + P ++ KA GV Sbjct: 51 ADYGDEAALTSALQGVEKLLLI---SSSEVGQ--RAPQH---------RNVINAAKAAGV 96 Query: 125 KNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLR 184 K + ++S T+P G E + + AD LLR Sbjct: 97 KFIAYTS-----------------LLHADTSPLG---LADEHIETEKMLADSGIVYTLLR 136 >5YSS-A nrPDB Length = 256 Score = 34.8 bits (78), Expect = 0.056, Method: Composition-based stats. Identities = 26/145 (17%), Positives = 50/145 (34%), Gaps = 26/145 (17%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + LVTG IG L +AG + G ++ + G++ + Sbjct: 6 KTALVTGSTSGIGLGIAQVLAQAGATLI---------LNGFGDVDAAKDAVAQYGKTPGY 56 Query: 63 EEMDILDQGALQRLFKKY-----SFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQL-- 115 D+ D+ + + + +I+ AG++ V P+D + N I L Sbjct: 57 HGADLSDEAQIADMMRYAESEFGGVDILINNAGIQHVSPIETFPVDKW--NAIIAINLSS 114 Query: 116 --------LEIMKAHGVKNLVFSSS 132 L M+A ++ +S Sbjct: 115 VFHTTRLALPGMRARNWGRIINIAS 139 >3D3W-A nrPDB Length = 244 Score = 34.8 bits (78), Expect = 0.063, Method: Composition-based stats. Identities = 40/227 (17%), Positives = 79/227 (34%), Gaps = 36/227 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 +VLVTG IG TV L G V + R L +R +E Sbjct: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAV------SRTQADLDSLVREC-----PGIEP 56 Query: 63 EEMDILDQGALQRLFKKYSF-MAVIHFAG----LKAVGESVQKPLDYYRVNLTGTIQLLE 117 +D+ D A +R +++ A + + + + VNL IQ+ + Sbjct: 57 VCVDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 Query: 118 IMKAHGVKN-----LVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLC 172 I+ + +V SS + + Y +K ++ M+ + Sbjct: 117 IVARGLIARGVPGAIVNVSSQC------------SQRAVTNHSVYCSTKGALD-MLTKVM 163 Query: 173 QADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGR 219 + + + + NPT S +G+ P+ ++++ +G+ Sbjct: 164 ALELGPHKIRVNAVNPTVVMTS--MGQATWSDPHKAKTMLNRIPLGK 208 >3MJ4-A nrPDB Length = 397 Score = 34.8 bits (78), Expect = 0.065, Method: Composition-based stats. Identities = 18/110 (16%), Positives = 36/110 (32%), Gaps = 5/110 (4%) Query: 6 LVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEM 65 L+ G AG+ GS L +G +++D + + + G + Sbjct: 33 LIVG-AGFAGSVLAERLASSGQRVLIVDRRPHIGGNAYDCYDDAGVLIHPYGPHI--FHT 89 Query: 66 DILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQL 115 + D F ++ H G+ + P++ VN + L Sbjct: 90 NSKDVFEYLSRFTEWRPYQ--HRVLASVDGQLLPIPINLDTVNRLYGLNL 137 >1Q7C-A nrPDB Length = 244 Score = 34.4 bits (77), Expect = 0.069, Method: Composition-based stats. Identities = 20/141 (14%), Positives = 48/141 (34%), Gaps = 23/141 (16%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 LVTG + IG L G + G + + + + G + + Sbjct: 8 ALVTGASRGIGRAIAETLAARGAKVI----------GTATSENGAQAISDYLGANGKGLM 57 Query: 65 MDILDQGALQRLFKKYS-----FMAVIHFAGLK----AVGESVQKPLDYYRVNLTGTIQL 115 +++ D +++ + +K +++ AG+ + ++ D NL+ +L Sbjct: 58 LNVTDPASIESVLEKIRAEFGEVDILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRL 117 Query: 116 ----LEIMKAHGVKNLVFSSS 132 + M ++ S Sbjct: 118 SKAVMRAMMKKRHGRIITIGS 138 >3PPI-A nrPDB Length = 281 Score = 34.4 bits (77), Expect = 0.072, Method: Composition-based stats. Identities = 16/75 (21%), Positives = 29/75 (38%), Gaps = 10/75 (13%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 +V+GGAG +G TV L G V+ D E + + + G EF Sbjct: 32 SAIVSGGAGGLGEATVRRLHADGLGVVIAD----------LAAEKGKALADELGNRAEFV 81 Query: 64 EMDILDQGALQRLFK 78 ++ + ++ + Sbjct: 82 STNVTSEDSVLAAIE 96 >4HP8-A nrPDB Length = 247 Score = 34.4 bits (77), Expect = 0.079, Method: Composition-based stats. Identities = 21/104 (20%), Positives = 35/104 (33%), Gaps = 9/104 (8%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 K LVTG +G + L AG V P+ + G + Sbjct: 10 RKALVTGANTGLGQAIAVGLAAAGAEVVCA---------ARRAPDETLDIIAKDGGNASA 60 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYR 106 +D D A + F F +++ AG+ +SV+ + Sbjct: 61 LLIDFADPLAAKDSFTDAGFDILVNNAGIIRRADSVEFSELDWD 104 >2HSD-A nrPDB Length = 253 Score = 34.4 bits (77), Expect = 0.083, Method: Composition-based stats. Identities = 39/169 (23%), Positives = 62/169 (36%), Gaps = 29/169 (17%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + V++TGGA +G+ + + AG V+ D R Q L V Sbjct: 6 KTVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATARELGDAARYQHL---DVTI 62 Query: 63 EEMDILDQGALQRLFKKY--SFMAVIHFAGLK----AVGESVQKPLDYYRVNLTGTI--- 113 EE D + ++ S +++ AG+ ESV++ +NLTG Sbjct: 63 EE----DWQRVVAYAREEFGSVDGLVNNAGISTGMFLETESVERFRKVVEINLTGVFIGM 118 Query: 114 -QLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSK 161 ++ MK G ++V SSA T+ YG SK Sbjct: 119 KTVIPAMKDAGGGSIVNISSAA------------GLMGLALTSSYGASK 155 >5L51-A nrPDB Length = 324 Score = 34.0 bits (76), Expect = 0.087, Method: Composition-based stats. Identities = 17/129 (13%), Positives = 39/129 (30%), Gaps = 9/129 (6%) Query: 14 IGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMD---ILD- 69 +GS ++ + + SL + G + + E D + D Sbjct: 63 LGSEFGDYVVSQQLDVADPASVAALVDFIKTKFGSLDILVNNAGLNGTYMEGDASVLNDY 122 Query: 70 -QGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEI----MKAHGV 124 + + + H + E+V+ + N G+ ++ E ++ Sbjct: 123 VEAEFKTFQSGAAKTEPYHPKATGRLVETVEHAKECIETNYYGSKRVTEALIPLLQQSDS 182 Query: 125 KNLVFSSSA 133 +V SS Sbjct: 183 PRIVNVSST 191 >5WQO-A nrPDB Length = 234 Score = 34.0 bits (76), Expect = 0.098, Method: Composition-based stats. Identities = 37/191 (19%), Positives = 62/191 (32%), Gaps = 27/191 (14%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 VL+ G + IG L+ G F A R GS L+ + E G ++ Sbjct: 8 NVLIVGASRGIGLGLADAFLQRGAQV-----FAVARRPQGSPG--LQALAERAGERLQAV 60 Query: 64 EMDILDQGALQRL---FKKYSFMAVIHFAG-----LKAVGE-SVQKPLDYYRVNLTGTIQ 114 D+ +R+ + +I AG + V E ++ + N ++ Sbjct: 61 TGDLNQHDCAERIGEMLGERRIDRLIVNAGIYGPQQQDVAEIDAEQTAQLFLTNAIAPLR 120 Query: 115 LLEIM--KAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLC 172 L + + + F SS L L P YG SK + ++R Sbjct: 121 LARALSGRVSRGGVVAFMSSQMA---SLALGLSATMPL------YGASKAALNSLVRSWE 171 Query: 173 QADKTWNAVLL 183 + LL Sbjct: 172 GEFEELPFSLL 182 >5DBI-A nrPDB Length = 374 Score = 33.6 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 29/161 (18%), Positives = 53/161 (32%), Gaps = 22/161 (13%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 LV G G +GS +L+ P + R + L + VE+ + Sbjct: 7 ALVVGVTGIVGSSLAE-VLKLPDTPGGPWKVYGVARRPCPVW--------LAKKPVEYIQ 57 Query: 65 MDILD-QGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTI-----QLLEI 118 D+ D Q + +L + + + +G + N+ ++ L + Sbjct: 58 CDVSDNQETISKLSPLKDITHIFY---VSWIGSEDCQTNATMFKNILNSVIPNASNLQHV 114 Query: 119 MKAHGVKNL--VFSSSATVYGNPQYLPLDEAHPTGGCTNPY 157 G+K+ +F + V P P E P N Y Sbjct: 115 CLQTGIKHYFGIFEEGSKV--VPHDSPFTEDLPRLNVPNFY 153 >2ZAT-A nrPDB Length = 260 Score = 33.6 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 29/172 (16%), Positives = 52/172 (30%), Gaps = 27/172 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + LVT IG L + G VV + + + + + L+ Sbjct: 15 KVALVTASTDGIGLAIARRLAQDGAHVVV----SSRKQENVDRTVATLQGEGLSVTGTVC 70 Query: 63 EEMDILDQGALQRL---FKKYSFMAVIHFAGLKAVGESVQKPLDYY----RVNLTGTIQL 115 D+ L + + V + A G + + + VN+ T+ + Sbjct: 71 HVGKAEDRERLVAMAVNLHGGVDILVSNAAVNPFFGNIIDATEEVWDKILHVNVKATVLM 130 Query: 116 LEI----MKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFF 163 + M+ G +++ SS Y HP PY SK Sbjct: 131 TKAVVPEMEKRGGGSVLIVSSVGAY-----------HPF-PNLGPYNVSKTA 170 >1O89-A nrPDB Length = 345 Score = 33.6 bits (75), Expect = 0.14, Method: Composition-based stats. Identities = 14/44 (31%), Positives = 21/44 (47%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPES 48 ++VTG +G +GS V L + GY V + + SL S Sbjct: 171 IVVTGASGGVGSTAVALLHKLGYQVVAVSGRESTHEYLKSLGAS 214 >4IS3-A nrPDB Length = 268 Score = 33.6 bits (75), Expect = 0.15, Method: Composition-based stats. Identities = 25/150 (16%), Positives = 58/150 (38%), Gaps = 11/150 (7%) Query: 6 LVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEM 65 ++TGG IG ++ G + + + L +E+ G + + Sbjct: 29 IITGGTRGIGFAAAKIFIDNGAKVSIFGETQEEVDTALAQLKELYPEEEVLGFAPDLTSR 88 Query: 66 DILDQGALQRLFKKY-SFMAVIHFAGLKAV----GESVQKPLDYYRVNLTGTIQ----LL 116 D + A+ ++ +KY +I+ AG+ + S ++ +N+TG Sbjct: 89 DAV-MAAVGQVAQKYGRLDVMINNAGITSNNVFSRVSEEEFKHIMDINVTGVFNGAWCAY 147 Query: 117 EIMKAHGVKNLVFSSSAT-VYGNPQYLPLD 145 + MK ++ ++S T ++G+ + Sbjct: 148 QCMKDAKKGVIINTASVTGIFGSLSGVGYP 177 >5B1Y-A nrPDB Length = 270 Score = 33.2 bits (74), Expect = 0.15, Method: Composition-based stats. Identities = 27/118 (22%), Positives = 45/118 (38%), Gaps = 8/118 (6%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 LVTGG+ IG TVL G+ V+ + + E RR+ +V Sbjct: 23 TTYALVTGGSRGIGRATVLRFAREGWSVVIA--YKSRADLAEKTAEEARRLGSPEAYTVR 80 Query: 62 FEEMDILDQGALQRLFKKYSF--MAVIHFAGLKAVG----ESVQKPLDYYRVNLTGTI 113 + D + + +++ AG+ +G S+ + + RVNLTG Sbjct: 81 VDVGDPDSVTEMSSRVGELIPHLNVLVNAAGVLQLGGIEETSISEWEETLRVNLTGVY 138 >4NBT-A nrPDB Length = 240 Score = 33.2 bits (74), Expect = 0.18, Method: Composition-based stats. Identities = 30/153 (19%), Positives = 59/153 (38%), Gaps = 30/153 (19%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + ++TGGA +G L E G + G L + + +VE Sbjct: 7 KVAVITGGAKGLGQAIALAYAEEGAKVI-----------AGDLGDLT-----YSHPNVEG 50 Query: 63 EEMDILDQGALQR----LFKKY-SFMAVIHFAGLK--AVGESVQKPLDY--YRVNLTGTI 113 +++ D +++ + KY +++ AG+ A+ + + VNL G Sbjct: 51 MYLNVTDVTGVEKFYQSVIDKYGKIDILVNNAGITKDAMTRKMTEAQWDAVIDVNLKGVF 110 Query: 114 QLLEI----MKAHGVKNLVFSSSAT-VYGNPQY 141 L + M+ +G +++ SS V+GN Sbjct: 111 NLTRLVGPQMQTNGYGSIINISSVVGVFGNIGQ 143 >5OKP-A nrPDB Length = 461 Score = 33.2 bits (74), Expect = 0.18, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 16/32 (50%) Query: 315 QEELGWTAALGLDRMCEDLWRWQKQNPSGFGT 346 +EE+ + +R D + W KQ P+G T Sbjct: 235 EEEISFPPTYRYERGSRDTYAWHKQKPTGVRT 266 >3NR8-B nrPDB Length = 316 Score = 33.2 bits (74), Expect = 0.18, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 16/32 (50%) Query: 315 QEELGWTAALGLDRMCEDLWRWQKQNPSGFGT 346 +EE+ + +R D + W KQ P+G T Sbjct: 236 EEEISFPPTYRYERGSRDTYAWHKQKPTGVRT 267 >3V2H-A nrPDB Length = 281 Score = 33.2 bits (74), Expect = 0.19, Method: Composition-based stats. Identities = 27/146 (18%), Positives = 53/146 (36%), Gaps = 18/146 (12%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M + ++TG IG L +AG V N F + V L+ +V Sbjct: 24 MTKTAVITGSTSGIGLAIARTLAKAGANIV-----LNGFGAPDEIRTVTDEVAGLSSGTV 78 Query: 61 EFEEMDILDQGALQRLFKKYSF-----MAVIHFAGLKAVGESVQKPLDYYR----VNLTG 111 D+ + + + +++ AG++ V + P++ + VNL+ Sbjct: 79 LHHPADMTKPSEIADMMAMVADRFGGADILVNNAGVQFVEKIEDFPVEQWDRIIAVNLSS 138 Query: 112 TIQLLEI----MKAHGVKNLVFSSSA 133 + + MK G ++ +SA Sbjct: 139 SFHTIRGAIPPMKKKGWGRIINIASA 164 >3PWS-A nrPDB Length = 366 Score = 32.8 bits (73), Expect = 0.20, Method: Composition-based stats. Identities = 27/108 (25%), Positives = 37/108 (34%), Gaps = 7/108 (6%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M V V G G +G+ + L E+ I +A G SL + + Sbjct: 1 MGYTVAVVGATGAVGAQMIKMLEESTLPIDKIRYLASARSAGKSLKFKDQDITIEETTET 60 Query: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVN 108 FE +DI A KY+ AV G V Y+R N Sbjct: 61 AFEGVDIALFSAGSSTSAKYAPYAV-------KAGVVVVDNTSYFRQN 101 >2BKA-A nrPDB Length = 242 Score = 32.8 bits (73), Expect = 0.20, Method: Composition-based stats. Identities = 24/130 (18%), Positives = 44/130 (33%), Gaps = 16/130 (12%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + V + G +G G + E+LE G + R + E + + V+F Sbjct: 19 KSVFILGASGETGRVLLKEILEQG----LFSKVTLIGRRKLTFDEEAY--KNVNQEVVDF 72 Query: 63 EEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH 122 E++D F+ + + RV+ ++ E+ KA Sbjct: 73 EKLD-----DYASAFQGHDVGFC-----CLGTTRGKAGAEGFVRVDRDYVLKSAELAKAG 122 Query: 123 GVKNLVFSSS 132 G K+ SS Sbjct: 123 GCKHFNLLSS 132 >3R3S-A nrPDB Length = 294 Score = 32.8 bits (73), Expect = 0.21, Method: Composition-based stats. Identities = 17/77 (22%), Positives = 26/77 (33%), Gaps = 5/77 (6%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 K LVTGG IG + G + N + ++ + E GR Sbjct: 50 RKALVTGGDSGIGRAAAIAYAREGADVAI-----NYLPAEEEDAQQVKALIEECGRKAVL 104 Query: 63 EEMDILDQGALQRLFKK 79 D+ D+ + L K Sbjct: 105 LPGDLSDESFARSLVHK 121 >5D01-A nrPDB Length = 379 Score = 32.8 bits (73), Expect = 0.22, Method: Composition-based stats. Identities = 16/108 (14%), Positives = 37/108 (34%), Gaps = 1/108 (0%) Query: 8 TGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDI 67 GG+G I + +L E G+ I + V+ ++ D+ Sbjct: 16 VGGSGIIATELGKQLAEKGHEIHFITSSIPFRLNTYHPNIHFHEVEVNQYAVFKYPPYDL 75 Query: 68 LDQGALQRLFKKYSFMAVI-HFAGLKAVGESVQKPLDYYRVNLTGTIQ 114 + + ++ + + H+A AV + K + + + T+ Sbjct: 76 TLASKIAEVAERENLDIIHAHYALPHAVCAYLAKQMLKRNIGIVTTLH 123 >1DOH-A nrPDB Length = 283 Score = 32.8 bits (73), Expect = 0.23, Method: Composition-based stats. Identities = 32/175 (18%), Positives = 58/175 (33%), Gaps = 22/175 (12%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRR---VQELTGRS 59 + LVTG IG +EL G +V N+ N+ + ++++ + Sbjct: 30 KVALVTGAGRGIGREMAMELGRRGCKVIV--NYANSTESAEEVVAAIKKNGSDAACVKAN 87 Query: 60 VEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDY---YRVNLTGTIQLL 116 V E + ++F K + + + P ++ + +N G + Sbjct: 88 VGVVEDIVRMFEEAVKIFGKLDIV-CSNSGVVSFGHVKDVTPEEFDRVFTINTRGQFFVA 146 Query: 117 -EIMKAHGV-KNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIR 169 E K + L+ S T G + +P Y SK IE R Sbjct: 147 REAYKHLEIGGRLILMGSIT--GQAKAVPK---------HAVYSGSKGAIETFAR 190 >3T7C-A nrPDB Length = 299 Score = 32.8 bits (73), Expect = 0.24, Method: Composition-based stats. Identities = 34/152 (22%), Positives = 58/152 (38%), Gaps = 22/152 (14%) Query: 3 EKVLVTGGA-GYIGSHTVLELLEAGYLPVV-----IDNFHNAFRGGGSLPESLRRVQELT 56 + +TG A G SH + E + + +D L E++R+V+ L Sbjct: 29 KVAFITGAARGQGRSHAITLAREGADIIAIDVCKQLDGVKLPMSTPDDLAETVRQVEAL- 87 Query: 57 GRSVEFEEMDILDQGALQRLFKK-----YSFMAVIHFAGLKAVGESVQ--KPLDY---YR 106 GR + ++D+ D A+Q V+ A L + G + P + Sbjct: 88 GRRIIASQVDVRDFDAMQAAVDDGVTQLGRLDIVLANAALASEGTRLNRMDPKTWRDMID 147 Query: 107 VNLTGT-----IQLLEIMKAHGVKNLVFSSSA 133 VNL G + + IM ++VF+SS Sbjct: 148 VNLNGAWITARVAIPHIMAGKRGGSIVFTSSI 179 >3H0K-A nrPDB Length = 178 Score = 32.5 bits (72), Expect = 0.26, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 27/63 (42%), Gaps = 5/63 (7%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNF-----HNAFRGGGSLPESLRRVQELTG 57 + +L+TG G S L E G +V+ + + G L + +R++E+ G Sbjct: 1 KVILITGMPGSGKSEFAKLLKERGAKVIVMSDVVRKRYSIEAKPGERLMDFAKRLREIYG 60 Query: 58 RSV 60 V Sbjct: 61 DGV 63 >5ER0-A nrPDB Length = 518 Score = 32.1 bits (71), Expect = 0.33, Method: Composition-based stats. Identities = 13/65 (20%), Positives = 23/65 (35%), Gaps = 1/65 (1%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 A+++ V G AGYIG+ G+ +ID + Q+ V+ Sbjct: 197 AKRITVIG-AGYIGAELAEAYSTTGHDVTLIDAMARVMPKYFDADFTDVIEQDYRDHGVQ 255 Query: 62 FEEMD 66 + Sbjct: 256 LALGE 260 >3V2G-A nrPDB Length = 271 Score = 32.1 bits (71), Expect = 0.33, Method: Composition-based stats. Identities = 13/77 (16%), Positives = 25/77 (32%), Gaps = 6/77 (7%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + VTGG+ IG+ L G + +++ E G Sbjct: 32 KTAFVTGGSRGIGAAIAKRLALEGAAV------ALTYVNAAERAQAVVSEIEQAGGRAVA 85 Query: 63 EEMDILDQGALQRLFKK 79 D D A+++ ++ Sbjct: 86 IRADNRDAEAIEQAIRE 102 >2X9N-A nrPDB Length = 288 Score = 32.1 bits (71), Expect = 0.38, Method: Composition-based stats. Identities = 47/230 (20%), Positives = 74/230 (32%), Gaps = 29/230 (12%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 +VTG A IG ++L + GY V+ +HN+ SL + L + + T + Sbjct: 26 AVVTGAAKRIGRAIAVKLHQTGYRVVIH--YHNSAEAAVSLADELNKERSNTAVVCQ--- 80 Query: 65 MDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGV 124 D+ + L ++ + V +Y L++ Sbjct: 81 ADLTNSNVLPASCEEI-INSCFR--AFGRCDVLVNNASAFYPT------PLVQGDHEDNS 131 Query: 125 K-NLVFSSSATVYGNPQYLPLDEAHPT---GGCTNPYGKSKFFIEEMIRDLCQADKTWNA 180 V + A + G P TNP S I +LC A Sbjct: 132 NGKTVETQVAELIGTNAIAPFLLTMSFAQRQKGTNPNCTS---SNLSIVNLCDAMVDQPC 188 Query: 181 VLLRYFNP-----TGAHASGCIGEDPQGI-PNNLMPYVSQ--VAIGRREA 222 + +N G S + P GI N + P VS VA+G E Sbjct: 189 MAFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPVAMGEEEK 238 >4CR6-A nrPDB Length = 271 Score = 32.1 bits (71), Expect = 0.39, Method: Composition-based stats. Identities = 13/31 (41%), Positives = 16/31 (51%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVID 33 + +VTG AG IG TV L G V +D Sbjct: 16 KAAIVTGAAGGIGRATVEAYLREGASVVAMD 46 >4BO1-A nrPDB Length = 269 Score = 32.1 bits (71), Expect = 0.39, Method: Composition-based stats. Identities = 42/235 (17%), Positives = 75/235 (31%), Gaps = 36/235 (15%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + LVTG + IG LE G L V+ + G + E+L+ G Sbjct: 28 KVALVTGASRGIGQAIA---LELGRLGAVVIGTATSASGAEKIAETLKA----NGVEGAG 80 Query: 63 EEMDILDQGALQRLFKKY-----SFMAVIHFAGLKAVGESVQKPLDYY----RVNLTGTI 113 +D+ ++ + + V++ AG+ V+ D + NL Sbjct: 81 LVLDVSSDESVAATLEHIQQHLGQPLIVVNNAGITRDNLLVRMKDDEWFDVVNTNLNSLY 140 Query: 114 QL----LEIMKAHGVKNLVFSSSAT-VYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMI 168 +L L M ++ S GN Y +K +E Sbjct: 141 RLSKAVLRGMTKARWGRIINIGSVVGAMGNAGQTN-------------YAAAKAGLEGFT 187 Query: 169 RDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREAL 223 R L + A+ + P G + E P+ L+ + +G+ E + Sbjct: 188 RALAREV-GSRAITVNAVAP-GFIDTDMTRELPEAQREALLGQIPLGRLGQAEEI 240 >1JB1-A nrPDB Length = 205 Score = 32.1 bits (71), Expect = 0.40, Method: Composition-based stats. Identities = 14/84 (16%), Positives = 34/84 (40%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 VL+TG +G S T LEL++ G+ + D + ++ + + Sbjct: 37 VLITGDSGVGKSETALELVQRGHRLIADDRVDVYQQDEQTIVGAAPPILSHLLEIRGLGI 96 Query: 65 MDILDQGALQRLFKKYSFMAVIHF 88 +D+++ + + + ++H Sbjct: 97 IDVMNLFGAGAVREDTTISLIVHL 120 >2I2W-A nrPDB Length = 212 Score = 31.7 bits (70), Expect = 0.46, Method: Composition-based stats. Identities = 18/122 (14%), Positives = 36/122 (29%), Gaps = 12/122 (9%) Query: 144 LDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQG 203 E P + D +N + RY G +G G Sbjct: 90 YRENRPGYPAI-------AISDVSHISCVGNDFGFNDIFSRYVEAVGREGDVLLGISTSG 142 Query: 204 IPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTG---VR--DYIHVVDLAKGHIAALRKL 258 N++ ++ + + + G D GT +R + + + + HI + L Sbjct: 143 NSANVIKAIAAAREKGMKVITLTGKDGGKMAGTADIEIRVPHFGYADRIQEIHIKVIHIL 202 Query: 259 KE 260 + Sbjct: 203 IQ 204 >3LFL-A nrPDB Length = 240 Score = 31.7 bits (70), Expect = 0.49, Method: Composition-based stats. Identities = 27/136 (19%), Positives = 51/136 (37%), Gaps = 25/136 (18%) Query: 99 QKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGG--CTNP 156 KP +++ N G + +LE + L++ S+ T LDEA+P +P Sbjct: 58 NKPEWFFKKNPFGLVPVLE----NSQGQLIYESAITC------EYLDEAYPGKKLLPDDP 107 Query: 157 YGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVA 216 Y K ++MI +L + +R N ED G+ +++ Sbjct: 108 YEK---ACQKMILELFSKVPSLVGSFIRSQN----------KEDYAGLKEEFRKEFTKLE 154 Query: 217 IGRREALNVFGNDYDT 232 + + FG + + Sbjct: 155 VLTNKKTTFFGGNSIS 170 >1DIR-A nrPDB Length = 241 Score = 31.7 bits (70), Expect = 0.51, Method: Composition-based stats. Identities = 17/76 (22%), Positives = 26/76 (34%), Gaps = 1/76 (1%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 A +VLV GG G +GS V + ID N + + E + V Sbjct: 7 ARRVLVYGGRGALGSRCVQAFRARNWWVASIDVVENEEASASVIVKMTDSFTEQADQ-VT 65 Query: 62 FEEMDILDQGALQRLF 77 E +L + + Sbjct: 66 AEVGKLLGDQKVDAIL 81 >4G65-A nrPDB Length = 461 Score = 31.7 bits (70), Expect = 0.52, Method: Composition-based stats. Identities = 15/100 (15%), Positives = 27/100 (27%), Gaps = 6/100 (6%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 A K+++ G AG +G L+ ++D + R + + V Sbjct: 3 AMKIIILG-AGQVGGTLAENLVGENNDITIVDKDGDRLRELQDKYDLRVVNGHASHPDV- 60 Query: 62 FEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKP 101 E D L + A + P Sbjct: 61 LHEAGAQDADMLV-AVTNTDET---NMAACQVAFTLFNTP 96 >2G17-A nrPDB Length = 337 Score = 31.3 bits (69), Expect = 0.63, Method: Composition-based stats. Identities = 14/84 (16%), Positives = 25/84 (29%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 L+ G +GY G+ V + ++ + G L L + Sbjct: 6 NTLIVGASGYAGAELVSYVNRHPHMTITALTVSAQSNDAGKLISDLHPQLKGIVDLPLQP 65 Query: 64 EMDILDQGALQRLFKKYSFMAVIH 87 D+ D A + + V H Sbjct: 66 MSDVRDFSADVDVVFLATAHEVSH 89 >1CYD-A nrPDB Length = 244 Score = 31.3 bits (69), Expect = 0.64, Method: Composition-based stats. Identities = 32/196 (16%), Positives = 60/196 (30%), Gaps = 34/196 (17%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 + LVTG IG TV L +G V + R L + +E Sbjct: 9 RALVTGAGKGIGRDTVKALHASGAKVVAV------TRTNSDLVSLAKEC-----PGIEPV 57 Query: 64 EMDILDQGALQRLFKKYSF-MAVIHFAG----LKAVGESVQKPLDYYRVNLTGTIQLLEI 118 +D+ D A ++ +++ A + + + + VNL Q+ ++ Sbjct: 58 CVDLGDWDATEKALGGIGPVDLLVNNAALVIMQPFLEVTKEAFDRSFSVNLRSVFQVSQM 117 Query: 119 MKAHGVKN-----LVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQ 173 + + +V SS H T Y +K + + + + Sbjct: 118 VARDMINRGVPGSIVNVSSMVA------------HVTFPNLITYSSTKGAMTMLTKAMAM 165 Query: 174 ADKTWNAVLLRYFNPT 189 + NPT Sbjct: 166 ELGPHKIRV-NSVNPT 180 >2B4Q-A nrPDB Length = 276 Score = 31.3 bits (69), Expect = 0.73, Method: Composition-based stats. Identities = 31/181 (17%), Positives = 52/181 (28%), Gaps = 26/181 (14%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 LVTGG+ IG LLEAG + A + + Q + + E Sbjct: 32 ALVTGGSRGIGQMIAQGLLEAGARVFICARDAEACADTATRLSAYGDCQAIPA-DLSSEA 90 Query: 65 MDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRV----NLTGTIQLLE--- 117 AL L + +++ AG P+ + N+T ++ Sbjct: 91 GARRLAQALGELSARLDI--LVNNAGTSWGAALESYPVSGWEKVMQLNVTSVFSCIQQLL 148 Query: 118 -----IMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLC 172 A ++ S YG SK + ++ R L Sbjct: 149 PLLRRSASAENPARVINIGSVAGISAMGEQAYA-----------YGPSKAALHQLSRMLA 197 Query: 173 Q 173 + Sbjct: 198 K 198 >1HXH-A nrPDB Length = 253 Score = 30.9 bits (68), Expect = 0.77, Method: Composition-based stats. Identities = 37/217 (17%), Positives = 74/217 (34%), Gaps = 37/217 (17%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + LVTGGA +G V LL G D + +++ G F Sbjct: 7 KVALVTGGASGVGLEVVKLLLGEGAKVAFSD----------INEAAGQQLAAELGERSMF 56 Query: 63 EEMDILDQGALQRLFKKYS-----FMAVIHFAGLKAVGESVQKPLDYYR----VN----L 109 D+ + + +++ AG+ G+ L+ + +N Sbjct: 57 VRHDVSSEADWTLVMAAVQRRLGTLNVLVNNAGILLPGDMETGRLEDFSRLLKINTESVF 116 Query: 110 TGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIR 169 G Q + MK G +++ +S + +LP+++ Y SK + + R Sbjct: 117 IGCQQGIAAMKETG-GSIINMASVS-----SWLPIEQ-------YAGYSASKAAVSALTR 163 Query: 170 DLCQADKTW-NAVLLRYFNPTGAHASGCIGEDPQGIP 205 + + A+ + +P G + P+G+ Sbjct: 164 AAALSCRKQGYAIRVNSIHPDGIYTPMMQASLPKGVS 200 >2LDB-A nrPDB Length = 317 Score = 30.9 bits (68), Expect = 0.78, Method: Composition-based stats. Identities = 26/132 (19%), Positives = 48/132 (36%), Gaps = 13/132 (9%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 +V+V G AG++G+ V L+ G ++ N + G + + V+ Sbjct: 8 RVVVIG-AGFVGASYVFALMNQGIADEIVLIDANESKAIGD-AMDFNHGKVFAPKPVDIW 65 Query: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHG 123 D D V+ AG A + + LD N+ ++E + A G Sbjct: 66 HGDYDDCR---------DADLVVICAG--ANQKPGETRLDLVDKNIAIFRSIVESVMASG 114 Query: 124 VKNLVFSSSATV 135 + L ++ V Sbjct: 115 FQGLFLVATNPV 126 >2AE2-A nrPDB Length = 260 Score = 30.9 bits (68), Expect = 0.80, Method: Composition-based stats. Identities = 35/180 (19%), Positives = 58/180 (32%), Gaps = 33/180 (18%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 LVTGG+ IG V EL G + + + + R + G VE Sbjct: 11 TALVTGGSRGIGYGIVEELASLGASVYT----CSRNQKELNDCLTQWRSK---GFKVEAS 63 Query: 64 EMDILDQGALQRLFKKY------SFMAVIHFAGLKAVGE----SVQKPLDYYRVNLTGTI 113 D+ + Q L +++ AG+ E +V+ +N Sbjct: 64 VCDLSSRSERQELMNTVANHFHGKLNILVNNAGIVIYKEAKDYTVEDYSLIMSINFEAAY 123 Query: 114 QLLEIM----KAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIR 169 L + KA N+VF SS + YG +K ++++ R Sbjct: 124 HLSVLAHPFLKASERGNVVFISSVS------------GALAVPYEAVYGATKGAMDQLTR 171 >4GBJ-A nrPDB Length = 297 Score = 30.9 bits (68), Expect = 0.81, Method: Composition-based stats. Identities = 26/110 (23%), Positives = 41/110 (37%), Gaps = 17/110 (15%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESL--RRVQELTGR 58 M+EK+ G G +G+ LLEAGY VV + + L ++ + +T Sbjct: 4 MSEKIAFLGL-GNLGTPIAEILLEAGYELVVWNRTASKAEPLTKLGATVVENAIDAITPG 62 Query: 59 SVEFEEMDILDQGALQRLF-----KKYSFMAVIHFAGLKAVGESVQKPLD 103 + F + D A++ LF +K V V S P Sbjct: 63 GIVFSV--LADDAAVEELFSMELVEKLGKDGV-------HVSMSTISPET 103 >2JJM-A nrPDB Length = 394 Score = 30.9 bits (68), Expect = 0.82, Method: Composition-based stats. Identities = 19/120 (15%), Positives = 44/120 (36%), Gaps = 6/120 (5%) Query: 1 MAEKVLVT-----GGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQEL 55 M K+ +T GG+G +G+ +L E G+ I + V Sbjct: 14 MKLKIGITCYPSVGGSGVVGTELGKQLAERGHEIHFITSGLPFRLNKVYPNIYFHEVTVN 73 Query: 56 TGRSVEFEEMDILDQGALQRLFKKYSFMAV-IHFAGLKAVGESVQKPLDYYRVNLTGTIQ 114 ++ D+ + + ++ + + +H+A A+ + K + R+ + T+ Sbjct: 74 QYSVFQYPPYDLALASKMAEVAQRENLDILHVHYAIPHAICAYLAKQMIGERIKIVTTLH 133 >1V9L-A nrPDB Length = 421 Score = 30.9 bits (68), Expect = 0.84, Method: Composition-based stats. Identities = 17/92 (18%), Positives = 36/92 (39%), Gaps = 7/92 (7%) Query: 10 GAGYIGSHTVLELLEAGYLPVVIDNFHN-AFRGGGSLPESLRRVQELTGRSVEFEEMDIL 68 G G +G T L + G + + + + A+R G E +++ + LTG ++ E Sbjct: 217 GMGNVGRWTAYWLEKMGAKVIAVSDINGVAYRKEGLNVELIQKNKGLTGPAL-VELFTTK 275 Query: 69 DQGALQRLFKKYSFMAVIHFAGLKAVGESVQK 100 D + + A+ V +++ Sbjct: 276 DNAEFVK-----NPDAIFKLDVDIFVPAAIEN 302 >4RZH-A nrPDB Length = 247 Score = 30.9 bits (68), Expect = 0.88, Method: Composition-based stats. Identities = 35/150 (23%), Positives = 59/150 (39%), Gaps = 12/150 (8%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFH-NAFRGGGSLPESLRRVQELTGRSV 60 A+ LVTG + IG T L L G VV N+ ++ + E + E Sbjct: 6 AQVALVTGASRGIGKATALALAATGMKVVV--NYAQSSTAADAVVAEIIANGGEAIAVQA 63 Query: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYY----RVNLTG----T 112 D +DQ L K +++ AG+ ++ L+ + +NLTG T Sbjct: 64 NVANADEVDQLIKTTLDKFSRIDVLVNNAGITRDTLLLRMKLEDWQAVIDLNLTGVFLCT 123 Query: 113 IQLLEIMKAHGVKNLVFSSS-ATVYGNPQY 141 + ++M ++ +S A + GNP Sbjct: 124 KAVSKLMLKQKSGRIINITSVAGMMGNPGQ 153 >3L0D-A nrPDB Length = 356 Score = 30.9 bits (68), Expect = 0.88, Method: Composition-based stats. Identities = 13/83 (15%), Positives = 31/83 (37%), Gaps = 2/83 (2%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 M+ +V + G G IG + + ++E+G + + ++ + Sbjct: 22 MSVRVAINGF-GRIGRNILRAIIESGRQDIEVVALNDLGSVETNAHLLRYDSVHGCFPGT 80 Query: 61 EFEEMDILDQG-ALQRLFKKYSF 82 D +D G +L ++F + Sbjct: 81 VQVVGDAIDIGSSLIKVFAERDP 103 >3ICS-A nrPDB Length = 588 Score = 30.9 bits (68), Expect = 0.88, Method: Composition-based stats. Identities = 18/80 (22%), Positives = 26/80 (32%), Gaps = 2/80 (2%) Query: 7 VTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMD 66 V GG G+IG V L E G V + N + + + VE D Sbjct: 192 VIGG-GFIGVEMVENLRERGIE-VTLVEMANQVMPPIDYEMAAYVHEHMKNHDVELVFED 249 Query: 67 ILDQGALQRLFKKYSFMAVI 86 +D + +VI Sbjct: 250 GVDALEENGAVVRLKSGSVI 269 >4NBV-A nrPDB Length = 246 Score = 30.9 bits (68), Expect = 0.93, Method: Composition-based stats. Identities = 27/144 (18%), Positives = 50/144 (34%), Gaps = 13/144 (9%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 ++TG A IG T E G + V+ D R + ++ V+ Sbjct: 8 AIITGAAAGIGFATAQRFAEDGAIVVLCD--VQEARVREAAARLAATGATVSAYRVDVTR 65 Query: 65 MDILDQGALQRLFKKYS-FMAVIHFAGLKAVGESVQKPLDYY----RVNLTGTIQLLEI- 118 D +D + + + +++ AG+ + + VNL G + Sbjct: 66 RDEVD-AMVAAVLAAHQRVDILVNNAGITKDARLAKMTEAQFDAVIDVNLKGVFNCAQAV 124 Query: 119 ---MKAHGVKNLVFSSSAT-VYGN 138 M G ++ +SS +YGN Sbjct: 125 AGLMTEQGKGVILNASSVVGLYGN 148 >5GXF-A nrPDB Length = 330 Score = 30.5 bits (67), Expect = 0.98, Method: Composition-based stats. Identities = 14/44 (31%), Positives = 17/44 (38%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPES 48 VLVTG AG +GS L GY + SL + Sbjct: 153 VLVTGAAGGVGSVATAILAHLGYEVAAVTGRPETADYLTSLGAT 196 >2YV2-A nrPDB Length = 297 Score = 30.5 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 11/28 (39%), Positives = 13/28 (46%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPV 30 +VLV G G GS +LE G V Sbjct: 14 TRVLVQGITGREGSFHAKAMLEYGTKVV 41 >5NUE-A nrPDB Length = 332 Score = 30.5 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 10/16 (62%), Positives = 11/16 (68%) Query: 4 KVLVTGGAGYIGSHTV 19 +VLVTG AG IG V Sbjct: 7 RVLVTGAAGQIGYALV 22 >4J6F-A nrPDB Length = 382 Score = 30.5 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 19/100 (19%), Positives = 31/100 (31%), Gaps = 9/100 (9%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVID---------NFHNAFRGGGSLPESLRRVQ 53 E VLVTG +G +GS + G +P+ + + + V+ Sbjct: 208 ETVLVTGASGGVGSAIIQLARARGAVPIAVAGPGKEAAMLDIGAQAVVTRGQGDLAEAVE 267 Query: 54 ELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKA 93 +G D++ L K AG A Sbjct: 268 AASGGRPIDVVADLVGGPLFNDLLKILRPEGRYTTAGAIA 307 >3A14-A nrPDB Length = 376 Score = 30.5 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 25/107 (23%), Positives = 46/107 (42%), Gaps = 8/107 (7%) Query: 1 MAEKVLVT-GGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRS 59 M E+ LV G G IG+ T+ L + + ++ +FH+ + + Sbjct: 1 MEERTLVILGATGSIGTQTLDVLKKVKGIRLIGISFHSNLELAFKIVKEFNVKNVAITGD 60 Query: 60 VEFEEMDI---LDQGALQRLFKKYSFM----AVIHFAGLKAVGESVQ 99 VEFE+ I +++ + + AV F+GL+AV S++ Sbjct: 61 VEFEDSSINVWKGSHSIEEMLEALKPDITMVAVSGFSGLRAVLASLE 107 >5I34-A nrPDB Length = 441 Score = 30.5 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 22/117 (18%), Positives = 37/117 (31%), Gaps = 12/117 (10%) Query: 210 PYVSQVAIGRREALNVFGNDYDTEDGTGVR-DYIHVVDLAKGHIAALRKLKEQCGCRIYN 268 P+ ++ E L G +Y T G R ++ + ++ G N Sbjct: 293 PFPTEDLATVGETLQEVGAEYGTVTGRRRRCGWLD--------LVVMKYSTMINGYTSLN 344 Query: 269 LGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALG 325 L T VL + ++ A+G KI V D+ GW + Sbjct: 345 L---TKLDVLDGFEEIKVATGYKIDGVEVEGFPADLDRLAKVEVQYATLPGWKTDIS 398 >1VIM-A nrPDB Length = 200 Score = 30.1 bits (66), Expect = 1.3, Method: Composition-based stats. Identities = 10/33 (30%), Positives = 15/33 (45%), Gaps = 2/33 (6%) Query: 2 AEKVLVTGG--AGYIGSHTVLELLEAGYLPVVI 32 A + V G +GYI + L+ GY V+ Sbjct: 47 ARSIFVIGAGRSGYIAKAFAMRLMHLGYTVYVV 79 >2DKN-A nrPDB Length = 255 Score = 30.1 bits (66), Expect = 1.3, Method: Composition-based stats. Identities = 35/206 (16%), Positives = 56/206 (27%), Gaps = 45/206 (21%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 + +TG A IG+ L AG+ + ID S P Sbjct: 4 IAITGSASGIGAALKELLARAGHTVIGIDRGQADIEADLSTPGGR--------------- 48 Query: 65 MDILDQGALQRLFKKYSFMAVIH-FAGLKAVGESVQKPLDYYRVNLTGTIQLLEIM---- 119 + A+ + + V+ VG + VN G LL+ + Sbjct: 49 -----ETAVAAVLDRCG--GVLDGLVCCAGVGVTAANSGLVVAVNYFGVSALLDGLAEAL 101 Query: 120 -KAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTN-------------PYGKSKFFIE 165 + ++ S A LP+ EA G Y SK+ + Sbjct: 102 SRGQQPAAVIVGSIAATQPGAAELPMVEAMLAGDEARAIELAEQQGQTHLAYAGSKYAVT 161 Query: 166 EMIRDLCQADKTWNAVLLRYFNPTGA 191 + R W +R N Sbjct: 162 CLARRNVV---DWAGRGVRL-NVVAP 183 >2PV7-A nrPDB Length = 298 Score = 30.1 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 9/31 (29%), Positives = 16/31 (51%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDN 34 K+++ GG G +G L +GY ++D Sbjct: 23 KIVIVGGYGKLGGLFARYLRASGYPISILDR 53 >1P33-A nrPDB Length = 289 Score = 30.1 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 19/58 (32%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 LVTG A +GS L GY + + A + + RR + Sbjct: 10 ALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAADASTLAATLNARRPNSAITVQADL 67 >4RZI-B nrPDB Length = 240 Score = 30.1 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 11/31 (35%), Positives = 15/31 (48%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVID 33 + ++VTGG IG+ V L E G D Sbjct: 9 KVIVVTGGNRGIGAAIVKLLQEMGAKVAFTD 39 >3MD0-A nrPDB Length = 355 Score = 29.8 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 28/135 (20%), Positives = 48/135 (35%), Gaps = 20/135 (14%) Query: 2 AEKVLVTGGAGYIGSHTV-----LELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELT 56 A +V +TG G +G T + L+E G+ V+ ++ R GGS+ R+ L Sbjct: 79 AHRVGITGVPG-VGKSTAIEALGMHLIERGHRVAVLAVDPSSTRTGGSILGDKTRMARLA 137 Query: 57 GRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAG--------LKAVGESVQKPLDYYRVN 108 + G L + + V+ A VG+S + N Sbjct: 138 VHPNAYIRPSPT-SGTLGGVTRATRETVVLLEAAGFDVILIETVGVGQS-----EVAVAN 191 Query: 109 LTGTIQLLEIMKAHG 123 + T LL + + Sbjct: 192 MVDTFVLLTLARTGD 206 >4XRR-A nrPDB Length = 456 Score = 29.8 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 25/115 (21%), Positives = 39/115 (33%), Gaps = 14/115 (12%) Query: 7 VTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMD 66 V GAGY+G+ + L G V +D+ G++ + L + Sbjct: 19 VIAGAGYVGTCLAVTLAGRGAEVVAVDS------DPGTVADLRAGRCRLPEPGLA---GA 69 Query: 67 ILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA 121 + D A RL S+ V V +V P D T QL+ + Sbjct: 70 VRDLAATGRLTASTSYDPV---GAADVVIVTVGTPTDAGH--EMVTDQLVAACEQ 119 >1KO7-A nrPDB Length = 314 Score = 29.8 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 20/58 (34%), Positives = 30/58 (51%), Gaps = 6/58 (10%) Query: 5 VLVTGGAGYIG-SHTVLELLEAGYLPVVIDNFH----NAFRGGGSLPESLRRVQELTG 57 VL+TG +G IG S T LEL++ G+ V DN + G P+ + + E+ G Sbjct: 147 VLITGDSG-IGKSETALELIKRGHRLVADDNVEIREISKDELIGRAPKLIEHLLEIRG 203 >2O23-A nrPDB Length = 265 Score = 29.8 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 23/130 (17%), Positives = 45/130 (34%), Gaps = 25/130 (19%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 ++TGGA +G T L+ G V++D G ++ + G + F Sbjct: 15 AVITGGASGLGLATAERLVGQGASAVLLD-----LPNSGGEAQAKK-----LGNNCVFAP 64 Query: 65 MDILDQGALQRLFKKYS-----FMAVIHFAG----------LKAVGESVQKPLDYYRVNL 109 D+ + +Q ++ AG K +++ VNL Sbjct: 65 ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNL 124 Query: 110 TGTIQLLEIM 119 GT ++ ++ Sbjct: 125 MGTFNVIRLV 134 >1NFF-A nrPDB Length = 260 Score = 29.4 bits (64), Expect = 2.3, Method: Composition-based stats. Identities = 28/141 (19%), Positives = 51/141 (36%), Gaps = 15/141 (10%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEF 62 + LV+GGA +G+ V ++ G V D + + R L Sbjct: 8 KVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAMAAELADAARYVHLDVTQPAQ 67 Query: 63 EEMDILDQGALQRLFKKYSFMAV-IHFAGLKAVGESVQKPLDYY----RVNLTGTI---- 113 + A+ + + V ++ AG+ +G L + VNLTG Sbjct: 68 W------KAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIR 121 Query: 114 QLLEIMKAHGVKNLVFSSSAT 134 +++ MK G +++ SS Sbjct: 122 AVVKPMKEAGRGSIINISSIE 142 >4UUP-A nrPDB Length = 341 Score = 29.4 bits (64), Expect = 2.4, Method: Composition-based stats. Identities = 8/20 (40%), Positives = 11/20 (55%) Query: 5 VLVTGGAGYIGSHTVLELLE 24 VL+TG AG IG + + Sbjct: 7 VLITGAAGQIGYALAFRIAK 26 >2TMD-A nrPDB Length = 729 Score = 29.4 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 20/78 (25%), Positives = 29/78 (37%), Gaps = 9/78 (11%) Query: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 VL+ G AG GS L+E+GY + D + L +V L G Sbjct: 391 SVLIVG-AGPSGSEAARVLMESGYTVHLTD-------TAEKIGGHLNQVAALPGLGEWSY 442 Query: 64 EMDILDQGALQRLFKKYS 81 D + + +L KK Sbjct: 443 HRDYR-ETQITKLLKKNK 459 >1JAY-A nrPDB Length = 212 Score = 29.4 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 10/29 (34%), Positives = 14/29 (48%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVV 31 +V + GG G +G L L G+ VV Sbjct: 1 MRVALLGGTGNLGKGLALRLATLGHEIVV 29 >4UUM-A nrPDB Length = 341 Score = 29.0 bits (63), Expect = 2.8, Method: Composition-based stats. Identities = 9/22 (40%), Positives = 14/22 (63%), Gaps = 1/22 (4%) Query: 5 VLVTGGAGYIGSHTVLELLEAG 26 VL+TG AG IG + + + +G Sbjct: 7 VLITGAAGQIG-YILSHWIASG 27 >6NCW-A nrPDB Length = 574 Score = 29.0 bits (63), Expect = 3.3, Method: Composition-based stats. Identities = 5/28 (17%), Positives = 13/28 (46%) Query: 319 GWTAALGLDRMCEDLWRWQKQNPSGFGT 346 W + ++ ++L++W + G G Sbjct: 432 KWYHDVPVEDYLDELYQWIQNESEGTGK 459 >5ENV-A nrPDB Length = 347 Score = 29.0 bits (63), Expect = 3.4, Method: Composition-based stats. Identities = 11/30 (36%), Positives = 15/30 (50%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDN 34 V ++G AG +GS V GY + ID Sbjct: 173 VAISGAAGGLGSLAVQYAKAMGYRVLGIDG 202 >3I83-A nrPDB Length = 320 Score = 29.0 bits (63), Expect = 3.6, Method: Composition-based stats. Identities = 11/34 (32%), Positives = 16/34 (47%), Gaps = 1/34 (2%) Query: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDN 34 M+ +LV G G IGS L + G+ V+ Sbjct: 1 MSLNILVIG-TGAIGSFYGALLAKTGHCVSVVSR 33 >4I1I-A nrPDB Length = 345 Score = 28.6 bits (62), Expect = 3.7, Method: Composition-based stats. Identities = 20/85 (23%), Positives = 27/85 (31%), Gaps = 10/85 (11%) Query: 2 AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVE 61 A KV VTG AG IG V L+ G L L + ++ L G E Sbjct: 24 AVKVAVTGAAGQIGYALVP-LIARGAL------LGPTTPVELRLLDIEPALKALAGVEAE 76 Query: 62 FEEMDILDQGALQRLFKKYSFMAVI 86 E+ L ++ Sbjct: 77 LED---CAFPLLDKVVVTADPRVAF 98 >5HKP-A nrPDB Length = 351 Score = 28.6 bits (62), Expect = 4.6, Method: Composition-based stats. Identities = 27/174 (15%), Positives = 43/174 (24%), Gaps = 15/174 (8%) Query: 10 GAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILD 69 AGY V LL+ G D + L MD+ Sbjct: 65 AAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQ 124 Query: 70 QGALQRLFKKYSFMAV----IHFAGLKAV---GESVQKPLDYYRVNLTGTI-----QLLE 117 L K H A V G+S + T LL+ Sbjct: 125 FTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQ 184 Query: 118 IMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTG-GCTNPYGKSKFFIEEMIRD 170 + + + + + + Q P + + K K E ++R Sbjct: 185 AAREADLAKVKKTLALEIINFKQ--PQSHETALHCAVASLHPKRKQVAELLLRK 236 >4UUO-A nrPDB Length = 340 Score = 28.2 bits (61), Expect = 5.6, Method: Composition-based stats. Identities = 7/20 (35%), Positives = 11/20 (55%) Query: 5 VLVTGGAGYIGSHTVLELLE 24 +L+TG AG IG + + Sbjct: 6 ILITGAAGQIGYALTFRIAK 25 >4YD8-A nrPDB Length = 411 Score = 27.8 bits (60), Expect = 6.5, Method: Composition-based stats. Identities = 18/113 (15%), Positives = 36/113 (31%), Gaps = 6/113 (5%) Query: 25 AGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMA 84 G +++ +F R P + E+D+ D + K S Sbjct: 39 NGQDKIIVGSFMGYLRIFSPHPAKTGDGAQAEDL---LLEVDLRDPVLQVEVGKFVSGTE 95 Query: 85 VIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYG 137 ++H A L + V G +++M H ++ ++ YG Sbjct: 96 MLHLAVLHSRKLCVYSVSGTLGNVEHGNQCQMKLMYEHNLQR---TACNMTYG 145 >1AHH-A nrPDB Length = 255 Score = 27.8 bits (60), Expect = 7.2, Method: Composition-based stats. Identities = 24/124 (19%), Positives = 44/124 (35%), Gaps = 17/124 (13%) Query: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 ++TG IG + AG VV D +A + +Q+L G++ Sbjct: 14 AIITGAGAGIGKEIAITFATAGASVVVSDINADAAN------HVVDEIQQLGGQAFAC-R 66 Query: 65 MDILDQGALQRL----FKKY-SFMAVIHFAGLKAVGESVQKPLDY----YRVNLTGTIQL 115 DI + L L K +++ AG + P+ Y +N+ L Sbjct: 67 CDITSEQELSALADFAISKLGKVDILVNNAG-GGGPKPFDMPMADFRRAYELNVFSFFHL 125 Query: 116 LEIM 119 +++ Sbjct: 126 SQLV 129 >5LZL-A nrPDB Length = 338 Score = 27.8 bits (60), Expect = 7.3, Method: Composition-based stats. Identities = 26/162 (16%), Positives = 51/162 (31%), Gaps = 25/162 (15%) Query: 192 HASGCIGEDPQGIPNNLMPYVSQVAIGRRE-----ALNVFGNDYDTEDGTGVRDYIHVVD 246 + G G DP+G+ + + ++ R L + + RD +V + Sbjct: 90 NPEGTGGYDPEGVVPRAIRLIKEIFGDRVLVFADVCLCEYTDHGHCGVVKEKRDRWYVDN 149 Query: 247 LAKGHIAALRKLKEQCGCRIYNLGTG-TGYSVLQMVQAMEKA---------------SGK 290 + A + + +G V ++ +A++ S Sbjct: 150 DETIKLYAKEAVVYAEAGADFVAPSGMMDGQVREIRRALDAHGFEEVGIMAYSAKYASAF 209 Query: 291 KIPYKVVARRE---GDVAACYANPSLAQEELGWTAALGLDRM 329 P++V A GD +P A E L A+ L+ Sbjct: 210 YGPFRVAAASAPKFGDRRTYQMDPRNAYEALK-EVAMDLEEG 250 >5JHQ-A nrPDB Length = 482 Score = 27.8 bits (60), Expect = 7.6, Method: Composition-based stats. Identities = 23/154 (14%), Positives = 35/154 (22%), Gaps = 14/154 (9%) Query: 10 GAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILD 69 AGY V LL+ G D + L MD+ Sbjct: 209 AAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQ 268 Query: 70 QGALQRLFKKYSFMAV----IHFAGLKAV---GESVQKPLDYYRVNLTGTI-----QLLE 117 L K H A V G+S + T LL+ Sbjct: 269 FTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQ 328 Query: 118 IMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTG 151 + + + + + + Q P Sbjct: 329 AAREADLAKVKKTLALEIINFKQ--PQSHETALH 360 >2R9Z-A nrPDB Length = 463 Score = 27.4 bits (59), Expect = 9.9, Method: Composition-based stats. Identities = 27/135 (20%), Positives = 39/135 (28%), Gaps = 23/135 (17%) Query: 3 EKVLVTGGAGYIGSHTVLELLEAGYLPVVI---DNFHNAFRGGGSLPESLRRVQELTGRS 59 ++V + G AGYIG L G V+ D F S + + Sbjct: 167 KRVAIIG-AGYIGIELAGLLRSFGSEVTVVALEDRLLFQFDPLLSATLAENMHAQGIETH 225 Query: 60 VEFEEMDILDQGALQRLFKK-----YSFMAVI-------------HFAGLKAVGESVQKP 101 +EF + L + F +VI A V + P Sbjct: 226 LEFAVAALERDAQGTTLVAQDGTRLEGFDSVIWAVGRAPNTRDLGLEAAGIEVQSNGMVP 285 Query: 102 LDYY-RVNLTGTIQL 115 D Y N+ G L Sbjct: 286 TDAYQNTNVPGVYAL 300 >5JS6-A nrPDB Length = 274 Score = 27.4 bits (59), Expect = 9.9, Method: Composition-based stats. Identities = 28/163 (17%), Positives = 48/163 (29%), Gaps = 33/163 (20%) Query: 19 VLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFK 78 V + +G V+ D + R E F D+ + ++ L Sbjct: 28 VRAFVNSGARVVICDKDESGGRAL-----------EQELPGAVFILCDVTQEDDVKTLVS 76 Query: 79 K-----YSFMAVIHFAG-----LKAVGESVQKPLDYYRVNLTGTIQLLEIMKAH---GVK 125 + V++ AG + S Q +NL GT L ++ + Sbjct: 77 ETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALPYLRKSQG 136 Query: 126 NLVFSSS-ATVYGNPQYLPLDE--------AHPTGGCTNPYGK 159 N++ SS G Q +P +PYG Sbjct: 137 NVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGV 179 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.124 0.321 Lambda K H 0.267 0.0382 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,545,481 Number of Sequences: 36641 Number of extensions: 468874 Number of successful extensions: 2204 Number of sequences better than 10.0: 237 Number of HSP's better than 10.0 without gapping: 178 Number of HSP's successfully gapped in prelim test: 133 Number of HSP's that attempted gapping in prelim test: 1689 Number of HSP's gapped (non-prelim): 333 length of query: 348 length of database: 10,336,785 effective HSP length: 98 effective length of query: 250 effective length of database: 6,745,967 effective search space: 1686491750 effective search space used: 1686491750 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 59 (27.4 bits)