BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q13507 (836 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6CUD-A nrPDB 1673 0.0 6CV9-A nrPDB 1257 0.0 6DJS-A nrPDB 629 e-180 6G1K-A nrPDB 546 e-155 5Z96-A nrPDB 517 e-147 6BWF-A nrPDB 55 2e-07 6BPQ-A nrPDB 54 2e-07 6DU8-A nrPDB 54 4e-07 5MKE-A nrPDB 52 1e-06 5Z1W-A nrPDB 51 2e-06 5AQA-A nrPDB 49 7e-06 5T4D-A nrPDB 49 7e-06 5AQ9-A nrPDB 49 9e-06 6D1W-A nrPDB 48 2e-05 5H76-A nrPDB 46 7e-05 6MWQ-A nrPDB 42 0.001 5MIO-C nrPDB 42 0.002 6FES-A nrPDB 40 0.004 5AQ7-A nrPDB 40 0.004 5IRX-A nrPDB 40 0.004 6MHW-A nrPDB 40 0.005 5AQB-A nrPDB 40 0.005 5GP7-A nrPDB 40 0.005 6BOA-A nrPDB 39 0.007 5CBO-A nrPDB 39 0.011 6BWI-A nrPDB 38 0.018 6E2G-A nrPDB 38 0.022 4OAU-C nrPDB 37 0.030 6DVZ-A nrPDB 37 0.045 1WG0-A nrPDB 35 0.11 3B7B-A nrPDB 35 0.11 6DMR-A nrPDB 35 0.16 6BY9-A nrPDB 35 0.17 5KKY-A nrPDB 32 1.2 4S1L-A nrPDB 32 1.7 4Z68-A nrPDB 31 2.1 6BBJ-A nrPDB 31 2.1 6C8G-A nrPDB 31 2.6 2KXP-C nrPDB 30 3.1 4LTR-A nrPDB 30 3.8 1DBP-A nrPDB 30 5.3 1G3N-B nrPDB 30 6.3 4O1O-A nrPDB 29 7.8 1TK9-A nrPDB 29 7.9 >6CUD-A nrPDB Length = 806 Score = 1673 bits (4332), Expect = 0.0, Method: Compositional matrix adjust. Identities = 806/806 (100%), Positives = 806/806 (100%) Query: 1 MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDY 60 MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDY Sbjct: 1 MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDY 60 Query: 61 MGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKR 120 MGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKR Sbjct: 61 MGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKR 120 Query: 121 LTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDY 180 LTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDY Sbjct: 121 LTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDY 180 Query: 181 FCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIE 240 FCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIE Sbjct: 181 FCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIE 240 Query: 241 KEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLA 300 KEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLA Sbjct: 241 KEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLA 300 Query: 301 IKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPC 360 IKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPC Sbjct: 301 IKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPC 360 Query: 361 SRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTT 420 SRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTT Sbjct: 361 SRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTT 420 Query: 421 QFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFL 480 QFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFL Sbjct: 421 QFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFL 480 Query: 481 QATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSR 540 QATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSR Sbjct: 481 QATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSR 540 Query: 541 IAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFT 600 IAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFT Sbjct: 541 IAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFT 600 Query: 601 TVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINS 660 TVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINS Sbjct: 601 TVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINS 660 Query: 661 SYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRR 720 SYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRR Sbjct: 661 SYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRR 720 Query: 721 RLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQV 780 RLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQV Sbjct: 721 RLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQV 780 Query: 781 DKENDEVNEGELKEIKQDISSLRYEL 806 DKENDEVNEGELKEIKQDISSLRYEL Sbjct: 781 DKENDEVNEGELKEIKQDISSLRYEL 806 >6CV9-A nrPDB Length = 842 Score = 1257 bits (3253), Expect = 0.0, Method: Compositional matrix adjust. Identities = 611/832 (73%), Positives = 708/832 (85%), Gaps = 25/832 (3%) Query: 21 GTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTEL 80 G+ L+ EEERFLDAAEYGNIPVVRKMLEE +LNVNCVDYMGQNALQLAV NEHLE+TEL Sbjct: 3 GSMLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITEL 62 Query: 81 LLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDE 140 LLKKENL+R+GDALLLAISKGYVRIVEAILNHP FA KRL SP + ELQ DDFYAYDE Sbjct: 63 LLKKENLSRVGDALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDE 122 Query: 141 DGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSR 200 DGTRFS D+TPIILAAHCQ+YE+VH LL KGARIERPHDYFCKC +C +KQ+HDSFSHSR Sbjct: 123 DGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCTECSQKQKHDSFSHSR 182 Query: 201 SRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVG 260 SRINAYKGLASPAYLSLSSEDPV+TALELSNELA LANIEKEFKNDYRKLSMQCKDFVVG Sbjct: 183 SRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYRKLSMQCKDFVVG 242 Query: 261 VLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLT 320 +LDLCR++EEVEAILNGD E+ +P + R +LSR+KLAIKYEVKKFVAHPNCQQQLL+ Sbjct: 243 LLDLCRNTEEVEAILNGDAETRQPGDFGR--PNLSRLKLAIKYEVKKFVAHPNCQQQLLS 300 Query: 321 IWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAAS 380 IWYENLSGLR+QT+A+K LVVL VA+GLPFLA+ YW APCS++GKILR PFMKFVAHAAS Sbjct: 301 IWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWCAPCSKMGKILRGPFMKFVAHAAS 360 Query: 381 FIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSE 440 F IFLGLLV NA+DRFEG LPN T TD +Q+FR+KT+ F+W EMLI+ WV+GM+W+E Sbjct: 361 FTIFLGLLVMNAADRFEGTKLLPNETSTDNARQLFRMKTSCFSWMEMLIISWVIGMIWAE 420 Query: 441 CKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSE 500 CKE+W +GP+EY+ +LWN+LDFGML+IF A+F ARF+AF A+KAQ +D+ DL++ Sbjct: 421 CKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTK 480 Query: 501 VTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGR 560 VTL ++Y+ AR KW P+DPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGR Sbjct: 481 VTLGDNVKYYNLARIKWDPTDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGR 540 Query: 561 TVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVT 620 TVKDIFKFMV+FIMVF AFMIGMF LYSYY+GAK N AFTTVEESFKTLFW+IFGLSEV Sbjct: 541 TVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVK 600 Query: 621 SVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKL 680 SVV+ Y+HKFIENIGYVLYG+YNVTMV+VLLNMLIAMINSS+QEIEDD+DVEWKFAR+KL Sbjct: 601 SVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKL 660 Query: 681 WLSYFDDGKTLPPPFSLVPSPKSFVYFIMR----IVNFPKCRRRRLQKDIEM-------- 728 W SYF++G+TLP PF+LVPSPKS +Y +++ + + +++ Q+D EM Sbjct: 661 WFSYFEEGRTLPVPFNLVPSPKSLLYLLLKFKKWMCELIQGQKQGFQEDAEMNKRNEEKK 720 Query: 729 -GMGNSKSRLNLFT----------QSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLK 777 G+ S L+ F+ QS++R E + NS N P +YQ+IMKRLIKRYVL+ Sbjct: 721 FGISGSHEDLSKFSLDKNQLAHNKQSSTRSSEDYHLNSFSNPPRQYQKIMKRLIKRYVLQ 780 Query: 778 AQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLN 829 AQ+DKE+DEVNEGELKEIKQDISSLRYELLE+KSQ TE+LA LI KL E+L+ Sbjct: 781 AQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRKLGERLS 832 >6DJS-A nrPDB Length = 676 Score = 629 bits (1621), Expect = e-180, Method: Compositional matrix adjust. Identities = 299/299 (100%), Positives = 299/299 (100%) Query: 1 MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDY 60 MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDY Sbjct: 18 MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDY 77 Query: 61 MGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKR 120 MGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKR Sbjct: 78 MGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKR 137 Query: 121 LTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDY 180 LTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDY Sbjct: 138 LTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDY 197 Query: 181 FCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIE 240 FCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIE Sbjct: 198 FCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIE 257 Query: 241 KEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKL 299 KEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKL Sbjct: 258 KEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKL 316 Score = 153 bits (386), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 76/76 (100%), Positives = 76/76 (100%) Query: 761 TRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAIL 820 TRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAIL Sbjct: 601 TRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAIL 660 Query: 821 IHKLSEKLNPSMLRCE 836 IHKLSEKLNPSMLRCE Sbjct: 661 IHKLSEKLNPSMLRCE 676 >6G1K-A nrPDB Length = 921 Score = 546 bits (1407), Expect = e-155, Method: Compositional matrix adjust. Identities = 314/802 (39%), Positives = 458/802 (57%), Gaps = 94/802 (11%) Query: 22 TSLTAEEERFLDAAEYGNIPVVRKMLEESK---TLNVNCVDYMGQNALQLAVGNEHLEVT 78 + L+ +E+ +L A E G+ V+ LEE++ +N+NC+D +G+ AL +A+ NE+LE+ Sbjct: 27 SELSTQEKSYLSAVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAIENENLEII 86 Query: 79 ELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAY 138 ELLL +GDALL AI K V VE +LNH + K++ +++ D Sbjct: 87 ELLLSFN--VYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSD------ 138 Query: 139 DEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSH 198 F+PDITPIILAAH YE++ ML+ KG + +PH+ C C +C+ DS H Sbjct: 139 ------FTPDITPIILAAHTNNYEIIKMLVQKGVSVPQPHEVRCNCVECVSSSDVDSLRH 192 Query: 199 SRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFV 258 SRSR+N YK LASP+ ++LSSEDP LTA +LS EL +L+ +E EFK +Y +LS QCK F Sbjct: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKAEYEELSHQCKHFA 252 Query: 259 VGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQL 318 +LD R S E+E ILN L L+R+KLAIKY K+FVA PNCQQ L Sbjct: 253 KDLLDQTRSSRELELILN--FRDDMNLLQDEANNELARLKLAIKYRQKEFVAQPNCQQLL 310 Query: 319 LTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHA 378 + WY+ G R + A K + + + L P L++ Y +AP SR G +R PF+KF+ H Sbjct: 311 ASRWYDEFPGWRRRHWAGKLITCVFIGLMFPLLSLCYLVAPKSRYGLFIRKPFIKFICHT 370 Query: 379 ASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMW 438 AS++ FL LL+ + V++ P + TT E +I+ WVLG +W Sbjct: 371 ASYLTFLFLLLLASQH-----------IVSNNPDRQGPKPTT----VEWMILPWVLGFIW 415 Query: 439 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 498 +E K++W G ++YI WN++DF M S+++A + + +A+++ + + Sbjct: 416 TEIKQMWDGGFQDYIHDWWNLMDFVMNSLYLATISLKIVAYVKYSGCK------------ 463 Query: 499 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 558 RD W P +++E ++AIA + S R+ + AN GPLQISL Sbjct: 464 --------------PRDTWEMWHPTLVAEAVFAIANIFSSLRLISLFTANSHLGPLQISL 509 Query: 559 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGA-----------KVNAAFTTVEESFK 607 GR + DI KF+ ++ +V AF G+ LY YY + + N AF+T+ E+ + Sbjct: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYENSEGMTCKGIRCERQNNAFSTLFETLQ 569 Query: 608 TLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIED 667 +LFWSIFGL + +K DHKF E +G ++G YNV +VVLLNMLIAM+N+SYQ I D Sbjct: 570 SLFWSIFGLISLYVTNVKADHKFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQHIAD 629 Query: 668 DSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRI-VNFPKCRRRRLQKDI 726 +D+EWKFAR+KLW+SYF++G TLPPPF+++PSPKS Y I I V+ K R +R + Sbjct: 630 HADIEWKFARTKLWMSYFEEGGTLPPPFNIIPSPKSICYLITWIKVHVFKRRSKRTET-- 687 Query: 727 EMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDE 786 F R E+ N +YQ++++ L+KRYV D + +E Sbjct: 688 -------------FGTLGRRAAENVRLNH------QYQEVLRNLVKRYVAAMIRDAKTEE 728 Query: 787 -VNEGELKEIKQDISSLRYELL 807 + E KE+KQDISS RYE++ Sbjct: 729 GLTEENFKELKQDISSFRYEVI 750 >5Z96-A nrPDB Length = 755 Score = 517 bits (1331), Expect = e-147, Method: Compositional matrix adjust. Identities = 315/801 (39%), Positives = 463/801 (57%), Gaps = 91/801 (11%) Query: 22 TSLTAEEERFLDAAEYGNIPVVRKMLEESK---TLNVNCVDYMGQNALQLAVGNEHLEVT 78 + L+ E+ +L+A E G+ V+K LEE++ +N+NC+D +G+ AL +A+ NE+LE+ Sbjct: 27 SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86 Query: 79 ELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAY 138 ELLL +GDALL AI K V VE +LNH + K++ P L D F Sbjct: 87 ELLLSFN--VYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQV--PPI---LLDKQF--- 136 Query: 139 DEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSH 198 + F+PDITPIILAAH YE++ +L+ KG + RPH+ C C +C+ DS H Sbjct: 137 ----SEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192 Query: 199 SRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFV 258 SRSR+N YK LASP+ ++LSSEDP LTA +LS EL +L+ +E EFK++Y +LS QCK F Sbjct: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252 Query: 259 VGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQL 318 +LD R S E+E ILN +++ L + L+R+KLAIKY K+FVA PNCQQ L Sbjct: 253 KDLLDQTRSSRELEIILNYRDDNS--LIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLL 310 Query: 319 LTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHA 378 + WY+ G R + A+K + ++ L P ++ Y IAP S LG +R PF+KF+ H Sbjct: 311 ASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHT 370 Query: 379 ASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMW 438 AS++ FL LL+ + +I +D +Q T E +I+ WVLG +W Sbjct: 371 ASYLTFLFLLLLASQ----------HIDRSDLNRQ-----GPPPTIVEWMILPWVLGFIW 415 Query: 439 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 498 E K++W G ++YI WN++DF M S+++A + + +AF++ + Sbjct: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYS--------------- 460 Query: 499 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 558 L P R+ W P +++E L+AIA + S R+ + AN GPLQISL Sbjct: 461 ---ALNP--------RESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509 Query: 559 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYY-----------LGAKVNAAFTTVEESFK 607 GR + DI KF+ ++ +V AF G+ LY YY K N AF+T+ E+ + Sbjct: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIRCEKQNNAFSTLFETLQ 569 Query: 608 TLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIED 667 +LFWSIFGL + +K H+F E +G ++G YNV +VVLLNMLIAM+N+SYQ I D Sbjct: 570 SLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIAD 629 Query: 668 DSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIE 727 +D+EWKFAR+KLW+SYF++G TLP PF+++PSPKS Y + I C+++ +K Sbjct: 630 HADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLVKWIWTH-LCKKKMRRKPES 688 Query: 728 MGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDE- 786 G ++ N L + +YQ++M+ L+KRYV + + +E Sbjct: 689 FGTIGRRAADN------------------LRRHHQYQEVMRNLVKRYVAAMIREAKTEEG 730 Query: 787 VNEGELKEIKQDISSLRYELL 807 + E +KE+KQDISS R+E+L Sbjct: 731 LTEENVKELKQDISSFRFEVL 751 >6BWF-A nrPDB Length = 954 Score = 54.7 bits (130), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 42/204 (20%), Positives = 91/204 (44%), Gaps = 22/204 (10%) Query: 529 LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGM-FILY 587 +Y + ++ + R+ L N+ GP + +G+ V ++F +V+ +V +F + ILY Sbjct: 618 IYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILY 677 Query: 588 SYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENI-------GYVLYG 640 + +++ ++ +W IFG + + + + I L Sbjct: 678 PHE-----EPSWSLAKDIVFHPYWMIFGEVYAYEIDVCANDSTLPTICGPGTWLTPFLQA 732 Query: 641 IYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPS 700 +Y ++++N+LIA N+ Y +++ S++ WK+ R ++Y + LPPP ++ Sbjct: 733 VYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAY-HEKPVLPPPLIILSH 791 Query: 701 PKSFVYFIMRIVNFPKCRRRRLQK 724 S + C+RR+ K Sbjct: 792 IVSLFCCV--------CKRRKKDK 807 >6BPQ-A nrPDB Length = 950 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 91/393 (23%), Positives = 160/393 (40%), Gaps = 64/393 (16%) Query: 297 VKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYW 356 ++LA++ ++F+A P Q L WY +S + I CL + +G F I + Sbjct: 532 LELAVEARDQQFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFFFPL-IGCGF--ISFR 588 Query: 357 IAPCSRLGKI-------LRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTD 409 P + K+ SPF+ F + +I FL L + + + D Sbjct: 589 KKPVEKTKKLFLYYVSFFTSPFVVFSWNVIFYIAFLLLFAY--------------VLLMD 634 Query: 410 YPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFI 469 + K+ T E+++ V V ++ E ++ ++ G + Y LWNV+D + FI Sbjct: 635 FQKEP--------TALEIILYVLVFILLCDEVRQWYMNGSK-YFSDLWNVMDTLAIFYFI 685 Query: 470 AAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGL 529 A R L + ++ Y + D TL I FT +R+ P+II Sbjct: 686 AGIVFR----LHSDESSWYSGRVIFCLDYIVFTLRL-IHIFTVSRNL----GPKIIMLQR 736 Query: 530 YAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSY 589 I V A + A FG + + R K+ ++ +F V + + MF Y Sbjct: 737 MMIDVFFFLFLFAVWMVA---FGVARQGILR--KNEHRWEWIFRSVIYEPYLAMFGQYPD 791 Query: 590 YL-GAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDH----KFIENIGYVLYGIYNV 644 + G N T F +E + ++ D +F E I L IY + Sbjct: 792 DIDGTTYNFDHCT------------FSGNESKPLCVELDANNQPRFPEWITIPLVCIYML 839 Query: 645 TMVVVLLNMLIAMINSSYQEIEDDSDVEWKFAR 677 + ++L+N+L+AM + +++++D WKF R Sbjct: 840 STNILLVNLLVAMFGYTVGSVQENNDQVWKFQR 872 >6DU8-A nrPDB Length = 805 Score = 53.5 bits (127), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 78/338 (23%), Positives = 148/338 (43%), Gaps = 59/338 (17%) Query: 354 GYWIA-PCSRLG--KILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDY 410 GY++ P SR G + LR+ + ++F+ V+NA+ + L V ++ Sbjct: 269 GYYLDLPGSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRL----VVEF 324 Query: 411 PK--------QIFRVKTTQF--TW------TEMLIMVWVLGMMWSECKELWLEGPREYIL 454 P QI VK ++ W E++ V++ + E EL + R Y+ Sbjct: 325 PATGGAIPSWQIRTVKLIRYVSNWDFFIVGCEVIFCVFIFYYVVEEILELHIHRLR-YLS 383 Query: 455 QLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYAR 514 +WN+LD L + + + A + + + + +Q+ + TYA Sbjct: 384 SIWNILD---LVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPN-------------TYAD 427 Query: 515 DKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIM 574 ++L + Q + A+ + ++ +I + N++ L +L R KDI F V+F + Sbjct: 428 FEFL-AFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFI 486 Query: 575 VFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIEN- 633 VFFA+ ++L F T E+F T IF ++ ++ +D+ I+N Sbjct: 487 VFFAYAQLGYLL------------FGTQVENFSTFIKCIF--TQFRIILGDFDYNAIDNA 532 Query: 634 ---IGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDD 668 +G + Y + VLLNM +A+IN +Y E++++ Sbjct: 533 NRILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKEE 570 >5MKE-A nrPDB Length = 968 Score = 52.0 bits (123), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 42/152 (27%), Positives = 71/152 (46%), Gaps = 22/152 (14%) Query: 523 QIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIG 582 QI + A+ V + ++ + N + L ++ R KD+F F ++F ++F A+ Sbjct: 555 QIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQL 614 Query: 583 MFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKF--IENIGYVLYG 640 ++++ G +V+ F+T +E T F I G D F IE VL Sbjct: 615 AYLVF----GTQVD-DFSTFQECIFTQFRIILG-----------DINFAEIEEANRVLGP 658 Query: 641 IY----NVTMVVVLLNMLIAMINSSYQEIEDD 668 IY M +LLNM +A+IN +Y E++ D Sbjct: 659 IYFTTFVFFMFFILLNMFLAIINDTYSEVKSD 690 >5Z1W-A nrPDB Length = 566 Score = 51.2 bits (121), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 71/303 (23%), Positives = 133/303 (43%), Gaps = 48/303 (15%) Query: 382 IIFLGLLVFNASDRFEGITTL----PNITVTDYPKQIFRVKTTQF--TW------TEMLI 429 ++F+ V+NA+ I L P T QI VK ++ W E++ Sbjct: 237 VVFIDFSVYNANINLFCILRLVVEFPATGGTIPSWQIRTVKLIRYVNNWDFFIVGCEVVF 296 Query: 430 MVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYV 489 V++ + E E+ L R Y+ +WN+LD L + + + A + + + + Sbjct: 297 CVFIFYYVVEEILEIHLHRLR-YLSSVWNILD---LVVILLSIVAVGFHIFRTLEVNRLM 352 Query: 490 DSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANE 549 +Q+ D TYA ++L + Q + A+ + ++ +I + N+ Sbjct: 353 GKLLQQPD-------------TYADFEFL-AFWQTQYNNMNAVNLFFAWIKIFKYISFNK 398 Query: 550 SFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTL 609 + L +L R KDI F ++F +VFFA+ ++L F T E+F T Sbjct: 399 TMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLL------------FGTQVENFSTF 446 Query: 610 FWSIFGLSEVTSVVLKYDHKFIENIGYVL----YGIYNVTMVVVLLNMLIAMINSSYQEI 665 IF ++ ++ +D+ I+N +L + Y + VLLNM +A+IN +Y E+ Sbjct: 447 VKCIF--TQFRIILGDFDYNAIDNANRILGPVYFVTYVFFVFFVLLNMFLAIINDTYSEV 504 Query: 666 EDD 668 +++ Sbjct: 505 KEE 507 >5AQA-A nrPDB Length = 418 Score = 49.3 bits (116), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 48/159 (30%), Positives = 67/159 (42%), Gaps = 33/159 (20%) Query: 30 RFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLAR 89 + L+AA G VR ++ + +VN D G L LA + HLE+ E+LLK Sbjct: 17 KLLEAARAGQDDEVRILM--ANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVD 74 Query: 90 IGDA-----LLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTR 144 D L LA G++ IVE +L + D A D DG Sbjct: 75 ASDVFGYTPLHLAAYWGHLEIVEVLLKNGA-------------------DVNAMDSDG-- 113 Query: 145 FSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCK 183 +TP+ LAA E+V +LL GA ++ D F K Sbjct: 114 ----MTPLHLAAKWGYKEIVEVLLKAGADVD-AQDKFGK 147 >5T4D-A nrPDB Length = 510 Score = 49.3 bits (116), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 42/152 (27%), Positives = 71/152 (46%), Gaps = 22/152 (14%) Query: 523 QIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIG 582 QI + A+ V + ++ + N + L ++ R KD+F F ++F ++F A+ Sbjct: 363 QIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQL 422 Query: 583 MFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKF--IENIGYVLYG 640 ++++ G +V+ F+T +E T F I G D F IE VL Sbjct: 423 AYLVF----GTQVD-DFSTFQECIFTQFRIILG-----------DINFAEIEEANRVLGP 466 Query: 641 IY----NVTMVVVLLNMLIAMINSSYQEIEDD 668 IY M +LLNM +A+IN +Y E++ D Sbjct: 467 IYFTTFVFFMFFILLNMFLAIINDTYSEVKSD 498 >5AQ9-A nrPDB Length = 422 Score = 48.9 bits (115), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 48/160 (30%), Positives = 66/160 (41%), Gaps = 33/160 (20%) Query: 30 RFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLAR 89 + L+AA G VR ++ + +VN D G L LA + HLE+ E+LLK Sbjct: 17 KLLEAARAGQDDEVRILM--ANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVD 74 Query: 90 IGDA-----LLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTR 144 D L LA G++ IVE +L + D A D DG Sbjct: 75 ASDVFGYTPLHLAAYWGHLEIVEVLLKNGA-------------------DVNAMDSDG-- 113 Query: 145 FSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKC 184 +TP+ LAA E+V +LL GA + D F K Sbjct: 114 ----MTPLHLAAKWGYLEIVEVLLKHGADV-NAQDKFGKT 148 >6D1W-A nrPDB Length = 740 Score = 48.1 bits (113), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 42/152 (27%), Positives = 71/152 (46%), Gaps = 22/152 (14%) Query: 523 QIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIG 582 QI + A+ V + ++ + N + L ++ R KD+F F ++ ++F A+ Sbjct: 503 QIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMPFIIFLAYAQL 562 Query: 583 MFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKF--IENIGYVLYG 640 ++++ G +V+ F+T +E T F I G D F IE VL Sbjct: 563 AYLVF----GTQVDD-FSTFQECIFTQFRIILG-----------DINFAEIEEANRVLGP 606 Query: 641 IYNVTMVV----VLLNMLIAMINSSYQEIEDD 668 IY T V +LLNM +A+IN +Y E++ D Sbjct: 607 IYFTTFVFFMFFILLNMFLAIINDTYSEVKSD 638 >5H76-A nrPDB Length = 201 Score = 45.8 bits (107), Expect = 7e-05, Method: Composition-based stats. Identities = 45/148 (30%), Positives = 62/148 (41%), Gaps = 32/148 (21%) Query: 30 RFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLAR 89 + L+AA G VR ++ + +VN D G L LA + HLE+ E+LLK Sbjct: 9 KLLEAARAGQDDEVRILM--ANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVD 66 Query: 90 IGDA-----LLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTR 144 D L LA G++ IVE +L + D A D DG Sbjct: 67 ASDVFGYTPLHLAAYWGHLEIVEVLLKNGA-------------------DVNAMDSDG-- 105 Query: 145 FSPDITPIILAAHCQKYEVVHMLLMKGA 172 +TP+ LAA E+V +LL GA Sbjct: 106 ----MTPLHLAAKWGYLEIVEVLLKHGA 129 >6MWQ-A nrPDB Length = 493 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 63/241 (26%), Positives = 98/241 (40%), Gaps = 43/241 (17%) Query: 29 ERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLA 88 ++ L+AA G VR ++ + +VN +D G L LA HLE+ E+LLK Sbjct: 7 KKLLEAARAGQDDEVRILM--ANGADVNALDRFGLTPLHLAAQRGHLEIVEVLLKCGADV 64 Query: 89 RIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGT 143 D L LA + G++ IVE +L + D A D G Sbjct: 65 NAADLWGQTPLHLAATAGHLEIVEVLLKYGA-------------------DVNALDLIGK 105 Query: 144 RFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCG-DCMEKQRHDSFSHSRSR 202 TP+ L A E+V +LL GA + D F K D ++ + + Sbjct: 106 ------TPLHLTAIDGHLEIVEVLLKHGADV-NAQDKFGKTAFDISIDNGNEDLAEILQK 158 Query: 203 INAYKGLASPAYLSLSSEDPVLTALELSNELAK-LANIEKEFKND----YRKLSMQCKDF 257 +N L+ A+ ++ +L A E + +AK L +I E + YR+L + D Sbjct: 159 LN----LSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDR 214 Query: 258 V 258 V Sbjct: 215 V 215 >5MIO-C nrPDB Length = 573 Score = 41.6 bits (96), Expect = 0.002, Method: Compositional matrix adjust. Identities = 47/160 (29%), Positives = 63/160 (39%), Gaps = 33/160 (20%) Query: 29 ERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLA 88 ++ L+AA G VR ++ + +VN D G L LA HLE+ E+LLK Sbjct: 412 KKLLEAARAGQDDEVRVLM--ANGADVNATDASGLTPLHLAATYGHLEIVEVLLKHGADV 469 Query: 89 RIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGT 143 D L LA G++ IVE +L H D A D G Sbjct: 470 SASDLMGSTPLHLAALIGHLEIVEVLLKHGA-------------------DVNAVDTWGD 510 Query: 144 RFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCK 183 TP+ LAA ++V LL GA + D F K Sbjct: 511 ------TPLRLAAVMGHLKIVEALLKHGADV-NAQDKFGK 543 >6FES-A nrPDB Length = 367 Score = 40.4 bits (93), Expect = 0.004, Method: Compositional matrix adjust. Identities = 50/162 (30%), Positives = 65/162 (40%), Gaps = 35/162 (21%) Query: 29 ERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLK----- 83 ++ L+AA G VR +L + +VN D G L LA HL + E+LLK Sbjct: 8 KKLLEAARAGQDDEVRILL--ANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADV 65 Query: 84 KENLARIGDALLLAISKGYVRIVEAIL-NHPGFAASKRLTLSPCEQELQDDDFYAYDEDG 142 N R L LA G++ IVE +L N G A+ D G Sbjct: 66 NANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNAT--------------------DVIG 105 Query: 143 TRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKC 184 T P+ LAA E+V +LL GA R D F K Sbjct: 106 T------APLHLAAMWGHEEIVEVLLKNGAD-ARAQDKFGKT 140 Score = 35.4 bits (80), Expect = 0.10, Method: Compositional matrix adjust. Identities = 39/120 (32%), Positives = 55/120 (45%), Gaps = 11/120 (9%) Query: 25 TAEEERFLD---AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELL 81 TA+E F AA G++ +V +L+ +N N D G L LA HLE+ E+L Sbjct: 34 TADETGFTPLHLAAWEGHLGIVEVLLKNGADVNAN--DERGHTPLHLAAYTGHLEIVEVL 91 Query: 82 LKKENLAR----IGDA-LLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFY 136 LK IG A L LA G+ IVE +L + G A + ++L D+ Y Sbjct: 92 LKNGAGVNATDVIGTAPLHLAAMWGHEEIVEVLLKN-GADARAQDKFGKTPEDLARDNGY 150 >5AQ7-A nrPDB Length = 418 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 49/161 (30%), Positives = 66/161 (40%), Gaps = 35/161 (21%) Query: 29 ERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLK----- 83 ++ L+AA G VR +L + +VN D G L LA HL + E+LLK Sbjct: 16 KKLLEAARAGQDDEVRILL--ANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADV 73 Query: 84 KENLARIGDALLLAISKGYVRIVEAIL-NHPGFAASKRLTLSPCEQELQDDDFYAYDEDG 142 N R L LA G++ IVE +L N G A+ D G Sbjct: 74 NANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNAT--------------------DVIG 113 Query: 143 TRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCK 183 T P+ LAA E+V +LL GA ++ D F K Sbjct: 114 T------APLHLAAMWGYKEIVEVLLKAGADVD-AQDKFGK 147 Score = 37.4 bits (85), Expect = 0.029, Method: Compositional matrix adjust. Identities = 35/94 (37%), Positives = 45/94 (47%), Gaps = 10/94 (10%) Query: 25 TAEEERFLD---AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELL 81 TA+E F AA G++ +V +L+ +N N D G L LA HLE+ E+L Sbjct: 42 TADETGFTPLHLAAWEGHLGIVEVLLKNGADVNAN--DERGHTPLHLAAYTGHLEIVEVL 99 Query: 82 LKKENLAR----IGDA-LLLAISKGYVRIVEAIL 110 LK IG A L LA GY IVE +L Sbjct: 100 LKNGAGVNATDVIGTAPLHLAAMWGYKEIVEVLL 133 >5IRX-A nrPDB Length = 636 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 33/117 (28%), Positives = 56/117 (47%), Gaps = 11/117 (9%) Query: 562 VKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTS 621 ++D+ +FM ++++ F F + L K N+ ++T E FK F G E T Sbjct: 469 LRDLCRFMFVYLVFLFGFSTAVVTLIE---DGKYNSLYSTCLELFK--FTIGMGDLEFTE 523 Query: 622 VVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARS 678 YD K + +L Y + ++LLNMLIA++ + +I +S WK R+ Sbjct: 524 ---NYDFK---AVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRA 574 >6MHW-A nrPDB Length = 826 Score = 39.7 bits (91), Expect = 0.005, Method: Compositional matrix adjust. Identities = 31/155 (20%), Positives = 75/155 (48%), Gaps = 6/155 (3%) Query: 532 IAVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVLFIMVFFAFMIGMFILYSYY 590 +A+ L ++ + Y +S G + + + + D+ KF+ ++I+ F + + L Sbjct: 554 LAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKC 613 Query: 591 -LGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVV 649 K +++ + ++ LF GL ++ ++ + K+ ++L Y + V+ Sbjct: 614 PKDNKDCSSYGSFSDAVLELFKLTIGLGDLN---IQQNSKYPILFLFLLI-TYVILTFVL 669 Query: 650 LLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSY 684 LLNMLIA++ + + + +S+ W+ R++ L + Sbjct: 670 LLNMLIALMGETVENVSKESERIWRLQRARTILEF 704 >5AQB-A nrPDB Length = 428 Score = 39.7 bits (91), Expect = 0.005, Method: Compositional matrix adjust. Identities = 46/161 (28%), Positives = 65/161 (40%), Gaps = 34/161 (21%) Query: 29 ERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLA 88 ++ L+AA G R ++ + +VN +D +G L LA HLE+ E LLK Sbjct: 16 KKLLEAARAGQDDECRILM--ANGADVNALDEVGWTPLHLAAWG-HLEIVECLLKNGADV 72 Query: 89 RIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGT 143 D L LA G++ IVE +L + D A D+ G Sbjct: 73 NAADIDGYTPLHLAAFSGHLEIVEVLLKYGA-------------------DVNADDQAG- 112 Query: 144 RFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKC 184 TP+ LAA E+V +LL GA + D F K Sbjct: 113 -----FTPLHLAAIFGHLEIVEVLLKNGADV-NAQDKFGKT 147 Score = 32.3 bits (72), Expect = 0.79, Method: Compositional matrix adjust. Identities = 21/73 (28%), Positives = 38/73 (52%), Gaps = 3/73 (4%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDA 93 AA +G++ +V +L+ +VN D G+ LA+ N + ++ E+L K L ++ DA Sbjct: 119 AAIFGHLEIVEVLLKNGA--DVNAQDKFGKTPRDLAIDNGNEDIAEVLGKAATLVKVKDA 176 Query: 94 L-LLAISKGYVRI 105 L GY+ + Sbjct: 177 ADQLGARVGYIEL 189 >5GP7-A nrPDB Length = 169 Score = 39.7 bits (91), Expect = 0.005, Method: Composition-based stats. Identities = 25/65 (38%), Positives = 36/65 (55%), Gaps = 5/65 (7%) Query: 21 GTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNA--LQLAVGNEHLEVT 78 G+ L + LDAA+ G + V+K+ N+NC D G+N+ L LA G +LEV Sbjct: 3 GSDLLRGDAALLDAAKKGCLARVQKLCTPE---NINCRDTQGRNSTPLHLAAGYNNLEVA 59 Query: 79 ELLLK 83 E LL+ Sbjct: 60 EYLLE 64 >6BOA-A nrPDB Length = 742 Score = 39.3 bits (90), Expect = 0.007, Method: Compositional matrix adjust. Identities = 32/147 (21%), Positives = 64/147 (43%), Gaps = 10/147 (6%) Query: 531 AIAVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVLFIMVFFAFMIGMFILYSY 589 + A+VL + + Y + GP I + + + D+ +F L +V F +I++ Sbjct: 455 SFALVLGWCNVMYFAEGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQT 514 Query: 590 YLGAKVNAAFTTVEESFKT--LFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMV 647 ++ + F T LF +I +V D F+ +I Y + I Sbjct: 515 EDPEELGHFYDYPMALFSTFELFLTIIDGPANYNV----DLPFMYSITYAAFAI---IAT 567 Query: 648 VVLLNMLIAMINSSYQEIEDDSDVEWK 674 +++LN+LIAM+ ++ + + D W+ Sbjct: 568 LLMLNLLIAMMGDTHWRVAHERDELWR 594 >5CBO-A nrPDB Length = 176 Score = 38.9 bits (89), Expect = 0.011, Method: Composition-based stats. Identities = 30/89 (33%), Positives = 43/89 (48%), Gaps = 7/89 (7%) Query: 29 ERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLA 88 ++ L+AA G VR ++ + +VN +D G L LA H E+ E+LLK Sbjct: 5 KKLLEAAHAGQDDEVRILM--ANGADVNAMDNFGVTPLHLAAYWGHFEIVEVLLKYGADV 62 Query: 89 RIGDA-----LLLAISKGYVRIVEAILNH 112 DA L LA GY+ IVE +L + Sbjct: 63 NASDATGDTPLHLAAKWGYLGIVEVLLKY 91 >6BWI-A nrPDB Length = 977 Score = 38.1 bits (87), Expect = 0.018, Method: Compositional matrix adjust. Identities = 17/51 (33%), Positives = 33/51 (64%), Gaps = 1/51 (1%) Query: 648 VVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLV 698 ++L+N+LIAM + ++ +++ +SD+ WK R +L + F L PPF ++ Sbjct: 834 ILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRL-IREFHSRPALAPPFIVI 883 >6E2G-A nrPDB Length = 727 Score = 37.7 bits (86), Expect = 0.022, Method: Compositional matrix adjust. Identities = 31/158 (19%), Positives = 67/158 (42%), Gaps = 13/158 (8%) Query: 520 SDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVLFIMVFFA 578 SD +++ + A+VL + + Y + GP I + + + D+ +F L +V Sbjct: 446 SDGEVVP---MSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILG 502 Query: 579 FMIGMFILYSYYLGAKVNAAFTTVEESFKT--LFWSIFGLSEVTSVVLKYDHKFIENIGY 636 F +I++ ++ + F T LF +I V L + + Sbjct: 503 FASAFYIIFQTEDPDELGHFYDYPMALFSTFELFLTIIDGPANYDVDLPFMYS------- 555 Query: 637 VLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWK 674 + Y + + +++LN+LIAM+ ++ + + D W+ Sbjct: 556 ITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWR 593 >4OAU-C nrPDB Length = 699 Score = 37.4 bits (85), Expect = 0.030, Method: Compositional matrix adjust. Identities = 46/182 (25%), Positives = 80/182 (43%), Gaps = 43/182 (23%) Query: 31 FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNAL---QLAVGNEHLE-VTELLLKKE- 85 +DAAE G++ V++ +L+E +VN D MG+NAL L+ + +E +T LLL Sbjct: 152 LMDAAEKGHVEVLKILLDEMGA-DVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGA 210 Query: 86 ----NLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDED 141 R L+LA+ K ++ +V+ +L E+ D D D Sbjct: 211 DVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHI-------------EIND-----TDSD 252 Query: 142 GTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRS 201 G T ++LA + ++ +L +GA + CGD + R + + HS Sbjct: 253 GK------TALLLAVELKLKKIAELLCKRGASTD--------CGDLVMTARRN-YDHSLV 297 Query: 202 RI 203 ++ Sbjct: 298 KV 299 Score = 33.5 bits (75), Expect = 0.37, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 50/98 (51%), Gaps = 5/98 (5%) Query: 19 DRGTSLTAEEER----FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEH 74 D G + ER + A E ++ +V+++LE+ + + +N D G+ AL LAV + Sbjct: 207 DHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQ-EHIEINDTDSDGKTALLLAVELKL 265 Query: 75 LEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNH 112 ++ ELL K+ GD ++ A +V+ +L+H Sbjct: 266 KKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSH 303 >6DVZ-A nrPDB Length = 791 Score = 36.6 bits (83), Expect = 0.045, Method: Compositional matrix adjust. Identities = 32/160 (20%), Positives = 70/160 (43%), Gaps = 16/160 (10%) Query: 532 IAVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVLFIMVFFAFMIGMFILYSYY 590 +A+ L ++ + +S G + + + + D+ KF+ ++I+ F + + L Sbjct: 553 LAMALGWANMLAYTRGFQSMGMYSVMIQKVILHDVLKFLFVYILFLLGFGVALASLIEKC 612 Query: 591 LGAKVN-AAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGY-----VLYGIYNV 644 K + +++ + ++ LF GL D +N Y L Y + Sbjct: 613 SKDKKDCSSYGSFSDAVLELFKLTIGLG---------DLNIQQNSTYPILFLFLLITYVI 663 Query: 645 TMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSY 684 V+LLNMLIA++ + + + +S+ W+ R++ L + Sbjct: 664 LTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEF 703 >1WG0-A nrPDB Length = 243 Score = 35.4 bits (80), Expect = 0.11, Method: Compositional matrix adjust. Identities = 23/79 (29%), Positives = 39/79 (49%), Gaps = 5/79 (6%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD- 92 A GN+ VV+ + + ++N + G L LAVG + EV++ L++ RI D Sbjct: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 Query: 93 ----ALLLAISKGYVRIVE 107 L A S G ++++E Sbjct: 139 FNQIPLHRAASVGSLKLIE 157 >3B7B-A nrPDB Length = 237 Score = 35.4 bits (80), Expect = 0.11, Method: Composition-based stats. Identities = 36/146 (24%), Positives = 61/146 (41%), Gaps = 31/146 (21%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDA 93 AAE G++ + +++ ++ D + L A N HLE + L+K L DA Sbjct: 18 AAEAGHVDICHMLVQAGANIDTCSEDQ--RTPLMEAAENNHLEAVKYLIKAGALVDPKDA 75 Query: 94 -----LLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPD 148 L LA KG+ +V+ +L++ + QDD + Sbjct: 76 EGSTCLHLAAKKGHYEVVQYLLSN-----------GQMDVNCQDDGGW------------ 112 Query: 149 ITPIILAAHCQKYEVVHMLLMKGARI 174 TP+I A + ++V +LL KG+ I Sbjct: 113 -TPMIWATEYKHVDLVKLLLSKGSDI 137 Score = 30.8 bits (68), Expect = 2.2, Method: Composition-based stats. Identities = 26/82 (31%), Positives = 41/82 (50%), Gaps = 6/82 (7%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD- 92 AA+ G+ VV+ +L + ++VNC D G + A +H+++ +LLL K + I D Sbjct: 84 AAKKGHYEVVQYLLSNGQ-MDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDN 142 Query: 93 ----ALLLAISKGYVRIVEAIL 110 L A G V I E +L Sbjct: 143 EENICLHWAAFSGCVDIAEILL 164 >6DMR-A nrPDB Length = 730 Score = 34.7 bits (78), Expect = 0.16, Method: Compositional matrix adjust. Identities = 33/152 (21%), Positives = 63/152 (41%), Gaps = 20/152 (13%) Query: 531 AIAVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVLFIMVFFAFMIGMFILYSY 589 + A+VL + + Y + GP I + + + D+ +F L +V F I + Sbjct: 455 SFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQT 514 Query: 590 ----YLGAKVN---AAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIY 642 LG + A F+T E LF +I SV L + + + Y + Sbjct: 515 EDPNNLGEFSDYPTALFSTFE-----LFLTIIDGPANYSVDLPFMY-------CITYAAF 562 Query: 643 NVTMVVVLLNMLIAMINSSYQEIEDDSDVEWK 674 + +++LN+ IAM+ ++ + + D W+ Sbjct: 563 AIIATLLMLNLFIAMMGDTHWRVAQERDELWR 594 >6BY9-A nrPDB Length = 328 Score = 34.7 bits (78), Expect = 0.17, Method: Compositional matrix adjust. Identities = 36/146 (24%), Positives = 61/146 (41%), Gaps = 31/146 (21%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDA 93 AAE G++ + +++ ++ D + L A N HLE + L+K L DA Sbjct: 109 AAEAGHVDICHMLVQAGANIDTCSEDQ--RTPLMEAAENNHLEAVKYLIKAGALVDPKDA 166 Query: 94 -----LLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPD 148 L LA KG+ +V+ +L++ + QDD + Sbjct: 167 EGSTCLHLAAKKGHYEVVQYLLSNGQM-----------DVNCQDDGGW------------ 203 Query: 149 ITPIILAAHCQKYEVVHMLLMKGARI 174 TP+I A + ++V +LL KG+ I Sbjct: 204 -TPMIWATEYKHVDLVKLLLSKGSDI 228 Score = 30.0 bits (66), Expect = 4.4, Method: Compositional matrix adjust. Identities = 26/82 (31%), Positives = 41/82 (50%), Gaps = 6/82 (7%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD- 92 AA+ G+ VV+ +L + ++VNC D G + A +H+++ +LLL K + I D Sbjct: 175 AAKKGHYEVVQYLLSNGQ-MDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDN 233 Query: 93 ----ALLLAISKGYVRIVEAIL 110 L A G V I E +L Sbjct: 234 EENICLHWAAFSGCVDIAEILL 255 >5KKY-A nrPDB Length = 496 Score = 32.0 bits (71), Expect = 1.2, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 29/46 (63%), Gaps = 1/46 (2%) Query: 8 QAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIP-VVRKMLEESKT 52 ++ R PA + D+GT + +ER L ++++G+I V+R+ + KT Sbjct: 48 KSYRIPALLKTDKGTLIAGADERRLHSSDWGDIGMVIRRSEDNGKT 93 >4S1L-A nrPDB Length = 237 Score = 31.6 bits (70), Expect = 1.7, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 23/44 (52%), Gaps = 1/44 (2%) Query: 293 SLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAI 336 SL R++ Y+ KFV P+C + WY L G R +IA+ Sbjct: 134 SLDRIRPPCSYKRNKFVDLPSCGGRCEKAWYVELDG-RPVSIAV 176 >4Z68-A nrPDB Length = 155 Score = 31.2 bits (69), Expect = 2.1, Method: Composition-based stats. Identities = 26/84 (30%), Positives = 37/84 (44%), Gaps = 7/84 (8%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD- 92 AA Y + VV +L+ +V+ D G L A H EV ELL+K + + D Sbjct: 44 AAGYNRVSVVEYLLQHGA--DVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADL 101 Query: 93 ----ALLLAISKGYVRIVEAILNH 112 L A +KG I + +L H Sbjct: 102 WKFTPLHEAAAKGKYEICKLLLQH 125 >6BBJ-A nrPDB Length = 868 Score = 31.2 bits (69), Expect = 2.1, Method: Compositional matrix adjust. Identities = 41/169 (24%), Positives = 72/169 (42%), Gaps = 40/169 (23%) Query: 533 AVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVLFIMVFFAFMIGMFILYSYYL 591 A+VL + Y + G I L + + KD+F+F++++++ FMIG Y+ L Sbjct: 577 ALVLGWMNALYFTRGLKLTGTYSIMLQKILFKDLFRFLLVYLL----FMIG----YASAL 628 Query: 592 GAKVNAAFTTVEESFKT------------------------LFWSIFGLSEVTSV-VLKY 626 + +N T+ E +T LF G+ ++ + KY Sbjct: 629 VSLLNPC-TSQESCIETSSNCTVPEYPSCRDSSTFSKFLLDLFKLTIGMGDLEMINSAKY 687 Query: 627 DHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKF 675 FI +L Y + V+LLNMLIA++ + ++ +S WK Sbjct: 688 PAVFI-----ILLVTYIILTFVLLLNMLIALMGETVGQVSKESKQIWKL 731 >6C8G-A nrPDB Length = 675 Score = 30.8 bits (68), Expect = 2.6, Method: Compositional matrix adjust. Identities = 41/169 (24%), Positives = 72/169 (42%), Gaps = 40/169 (23%) Query: 533 AVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVLFIMVFFAFMIGMFILYSYYL 591 A+VL + Y + G I L + + KD+F+F++++++ FMIG Y+ L Sbjct: 446 ALVLGWMNALYFTRGLKLTGTYSIMLQKILFKDLFRFLLVYLL----FMIG----YASAL 497 Query: 592 GAKVNAAFTTVEESFKT------------------------LFWSIFGLSEVTSV-VLKY 626 + +N T+ E +T LF G+ ++ + KY Sbjct: 498 VSLLNPC-TSQESCIETSSQCTVPEYPSCRDSSTFSKFLLDLFKLTIGMGDLEMINSAKY 556 Query: 627 DHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKF 675 FI +L Y + V+LLNMLIA++ + ++ +S WK Sbjct: 557 PAVFI-----ILLVTYIILTFVLLLNMLIALMGETVGQVSKESKQIWKL 600 >2KXP-C nrPDB Length = 118 Score = 30.4 bits (67), Expect = 3.1, Method: Composition-based stats. Identities = 17/45 (37%), Positives = 23/45 (51%), Gaps = 1/45 (2%) Query: 134 DFYAYDEDGTR-FSPDITPIILAAHCQKYEVVHMLLMKGARIERP 177 D+ A ED R P+ AA C + E++ LL+KGA I P Sbjct: 20 DYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAP 64 >4LTR-A nrPDB Length = 152 Score = 30.4 bits (67), Expect = 3.8, Method: Compositional matrix adjust. Identities = 32/133 (24%), Positives = 61/133 (45%), Gaps = 26/133 (19%) Query: 552 GPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAA-----FTTVEESF 606 GP SL R + I +L +++F+ F + +G K+ A F T+ S Sbjct: 1 GPSSPSLLRAIPGIAWIALLLLVIFYVFAV---------MGTKLFAQSFPEWFGTLGASM 51 Query: 607 KTLF-------WSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMIN 659 TLF WS+ G++ V+ Y +I + ++L + + T++ + + ++I + Sbjct: 52 YTLFQVMTLESWSM-GIAR--PVIEAYPWAWIYFVSFIL--VSSFTVLNLFIGIIIESMQ 106 Query: 660 SSYQEIEDDSDVE 672 S+ E ED +E Sbjct: 107 SAGWEAEDAKRIE 119 >1DBP-A nrPDB Length = 271 Score = 29.6 bits (65), Expect = 5.3, Method: Composition-based stats. Identities = 26/111 (23%), Positives = 51/111 (45%), Gaps = 15/111 (13%) Query: 729 GMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVD-----KE 783 G ++ R F Q+ +H FN + +QP + +I + + +L A D + Sbjct: 134 GTSAARERGEGFQQA----VAAHKFNVLASQPADFDRIKGLNVMQNLLTAHPDVQAVFAQ 189 Query: 784 NDEVNEGELKEI----KQDISSLRYELLEDKSQATEE--LAILIHKLSEKL 828 NDE+ G L+ + K D+ + ++ D +A + LA I +L +++ Sbjct: 190 NDEMALGALRALQTAGKSDVMVVGFDGTPDGEKAVNDGKLAATIAQLPDQI 240 >1G3N-B nrPDB Length = 168 Score = 29.6 bits (65), Expect = 6.3, Method: Composition-based stats. Identities = 25/81 (30%), Positives = 33/81 (40%), Gaps = 7/81 (8%) Query: 3 EKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMG 62 E RR +RG DR DAA G + ++ +LE +N+ D G Sbjct: 51 EIARRLLLRGANPDLKDRTGFAVIH-----DAARAGFLDTLQTLLEFQADVNIE--DNEG 103 Query: 63 QNALQLAVGNEHLEVTELLLK 83 L LA HL V E L+K Sbjct: 104 NLPLHLAAKEGHLRVVEFLVK 124 >4O1O-A nrPDB Length = 717 Score = 29.3 bits (64), Expect = 7.8, Method: Compositional matrix adjust. Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 3/67 (4%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDA 93 A E N+ +V +ML E + + VN D G+ AL LAV E+ +LL + GD Sbjct: 229 AVERKNLDLV-QMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGD- 286 Query: 94 LLLAISK 100 L+AI++ Sbjct: 287 -LVAIAR 292 >1TK9-A nrPDB Length = 188 Score = 29.3 bits (64), Expect = 7.9, Method: Composition-based stats. Identities = 21/87 (24%), Positives = 44/87 (50%), Gaps = 4/87 (4%) Query: 12 GPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVG 71 G F+F+ + +L E++ + + G P V + L+++K LN+ C+ G+ + Sbjct: 95 GFEFVFSRQVEALGNEKDVLIGISTSGKSPNVLEALKKAKELNMLCLGLSGKGGGMMNKL 154 Query: 72 NEHLEVTELLLKKENLARIGDALLLAI 98 +H L++ ++ ARI + +L I Sbjct: 155 CDH----NLVVPSDDTARIQEMHILII 177 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6CUD-A nrPDB 1156 0.0 6CV9-A nrPDB 1093 0.0 6G1K-A nrPDB 906 0.0 5Z96-A nrPDB 881 0.0 6DJS-A nrPDB 465 e-131 6BPQ-A nrPDB 342 3e-94 6DU8-A nrPDB 271 1e-72 5Z1W-A nrPDB 264 1e-70 6BWF-A nrPDB 235 4e-62 6MWQ-A nrPDB 221 8e-58 5MKE-A nrPDB 201 9e-52 6D1W-A nrPDB 195 8e-50 5T4D-A nrPDB 195 1e-49 5H76-A nrPDB 174 1e-43 5AQ9-A nrPDB 172 5e-43 5MIO-C nrPDB 171 8e-43 5AQA-A nrPDB 163 3e-40 Sequences not found previously or not previously below threshold: 5AQB-A nrPDB 146 5e-35 6FES-A nrPDB 139 4e-33 5AQ7-A nrPDB 138 8e-33 5CBO-A nrPDB 115 8e-26 6BWI-A nrPDB 104 2e-22 4Z68-A nrPDB 91 1e-18 5JHQ-A nrPDB 85 1e-16 5HKP-A nrPDB 85 1e-16 5GP7-A nrPDB 85 1e-16 6DVZ-A nrPDB 74 3e-13 6MHW-A nrPDB 74 3e-13 6BY9-A nrPDB 73 5e-13 3B7B-A nrPDB 73 5e-13 4OAU-C nrPDB 69 7e-12 6BBJ-A nrPDB 68 1e-11 5IRX-A nrPDB 68 2e-11 6C8G-A nrPDB 68 2e-11 6BOA-A nrPDB 67 4e-11 6E2G-A nrPDB 66 5e-11 6DMR-A nrPDB 64 3e-10 2KXP-C nrPDB 63 4e-10 4NIK-A nrPDB 61 2e-09 3ZKJ-A nrPDB 60 4e-09 2DWZ-A nrPDB 59 7e-09 3TU9-A nrPDB 59 7e-09 2RFA-A nrPDB 58 2e-08 1G3N-B nrPDB 56 8e-08 5ET1-A nrPDB 55 1e-07 4O1O-A nrPDB 55 1e-07 6AUN-A nrPDB 53 8e-07 3EHQ-A nrPDB 52 9e-07 1XFB-A nrPDB 51 2e-06 1WG0-A nrPDB 51 3e-06 1BLX-B nrPDB 49 6e-06 4OT9-A nrPDB 49 9e-06 5DND-A nrPDB 49 1e-05 1BD8-A nrPDB 48 2e-05 5HI9-A nrPDB 48 2e-05 5D68-A nrPDB 47 4e-05 3LJN-A nrPDB 46 5e-05 1D9S-A nrPDB 46 6e-05 5EK0-A nrPDB 44 2e-04 2A5E-A nrPDB 44 2e-04 3UI2-A nrPDB 44 3e-04 6N4I-A nrPDB 44 3e-04 6BO5-A nrPDB 44 4e-04 5AN8-A nrPDB 43 5e-04 3DEO-A nrPDB 43 6e-04 5U0J-A nrPDB 42 0.001 5U0K-A nrPDB 42 0.001 2NYJ-A nrPDB 41 0.002 6OO7-A nrPDB 41 0.002 6EMK-G nrPDB 41 0.003 2ETB-A nrPDB 40 0.004 6AYG-A nrPDB 40 0.005 2F37-A nrPDB 39 0.006 3T9K-A nrPDB 39 0.009 3W9G-A nrPDB 38 0.019 5UQE-A nrPDB 38 0.019 3KX6-A nrPDB 38 0.019 5HVD-A nrPDB 37 0.027 4N5Q-A nrPDB 37 0.027 4LTR-A nrPDB 37 0.044 3RVY-A nrPDB 36 0.064 4DXW-A nrPDB 36 0.072 6NQ0-A nrPDB 36 0.10 6C96-A nrPDB 35 0.11 1FBA-A nrPDB 35 0.11 5HKD-A nrPDB 35 0.15 5TKC-A nrPDB 34 0.21 1F2J-A nrPDB 34 0.31 6EM5-I nrPDB 34 0.38 4DX2-A nrPDB 33 0.42 5O0W-A nrPDB 33 0.55 4BSZ-B nrPDB 32 1.2 6CXH-C nrPDB 31 1.6 5E1J-A nrPDB 31 2.6 6BQH-A nrPDB 31 2.8 3EU9-A nrPDB 31 2.9 3LVQ-E nrPDB 31 3.2 2B0O-E nrPDB 31 3.2 3JC6-4 nrPDB 30 3.6 3WOM-A nrPDB 30 4.2 6IRX-A nrPDB 30 4.9 4KP2-A nrPDB 30 5.3 4S1L-A nrPDB 29 7.3 5UIL-A nrPDB 29 8.5 4XD0-A nrPDB 29 9.0 >6CUD-A nrPDB Length = 806 Score = 1156 bits (2989), Expect = 0.0, Method: Composition-based stats. Identities = 806/806 (100%), Positives = 806/806 (100%) Query: 1 MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDY 60 MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDY Sbjct: 1 MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDY 60 Query: 61 MGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKR 120 MGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKR Sbjct: 61 MGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKR 120 Query: 121 LTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDY 180 LTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDY Sbjct: 121 LTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDY 180 Query: 181 FCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIE 240 FCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIE Sbjct: 181 FCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIE 240 Query: 241 KEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLA 300 KEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLA Sbjct: 241 KEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLA 300 Query: 301 IKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPC 360 IKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPC Sbjct: 301 IKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPC 360 Query: 361 SRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTT 420 SRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTT Sbjct: 361 SRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTT 420 Query: 421 QFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFL 480 QFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFL Sbjct: 421 QFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFL 480 Query: 481 QATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSR 540 QATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSR Sbjct: 481 QATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSR 540 Query: 541 IAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFT 600 IAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFT Sbjct: 541 IAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFT 600 Query: 601 TVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINS 660 TVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINS Sbjct: 601 TVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINS 660 Query: 661 SYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRR 720 SYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRR Sbjct: 661 SYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRR 720 Query: 721 RLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQV 780 RLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQV Sbjct: 721 RLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQV 780 Query: 781 DKENDEVNEGELKEIKQDISSLRYEL 806 DKENDEVNEGELKEIKQDISSLRYEL Sbjct: 781 DKENDEVNEGELKEIKQDISSLRYEL 806 >6CV9-A nrPDB Length = 842 Score = 1093 bits (2826), Expect = 0.0, Method: Composition-based stats. Identities = 609/832 (73%), Positives = 703/832 (84%), Gaps = 25/832 (3%) Query: 21 GTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTEL 80 G+ L+ EEERFLDAAEYGNIPVVRKMLEE +LNVNCVDYMGQNALQLAV NEHLE+TEL Sbjct: 3 GSMLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITEL 62 Query: 81 LLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDE 140 LLKKENL+R+GDALLLAISKGYVRIVEAILNHP FA KRL SP + ELQ DDFYAYDE Sbjct: 63 LLKKENLSRVGDALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDE 122 Query: 141 DGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSR 200 DGTRFS D+TPIILAAHCQ+YE+VH LL KGARIERPHDYFCKC +C +KQ+HDSFSHSR Sbjct: 123 DGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCTECSQKQKHDSFSHSR 182 Query: 201 SRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVG 260 SRINAYKGLASPAYLSLSSEDPV+TALELSNELA LANIEKEFKNDYRKLSMQCKDFVVG Sbjct: 183 SRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYRKLSMQCKDFVVG 242 Query: 261 VLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLT 320 +LDLCR++EEVEAILNGD E+ +P + R +LSR+KLAIKYEVKKFVAHPNCQQQLL+ Sbjct: 243 LLDLCRNTEEVEAILNGDAETRQPGDFGR--PNLSRLKLAIKYEVKKFVAHPNCQQQLLS 300 Query: 321 IWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAAS 380 IWYENLSGLR+QT+A+K LVVL VA+GLPFLA+ YW APCS++GKILR PFMKFVAHAAS Sbjct: 301 IWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWCAPCSKMGKILRGPFMKFVAHAAS 360 Query: 381 FIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSE 440 F IFLGLLV NA+DRFEG LPN T TD +Q+FR+KT+ F+W EMLI+ WV+GM+W+E Sbjct: 361 FTIFLGLLVMNAADRFEGTKLLPNETSTDNARQLFRMKTSCFSWMEMLIISWVIGMIWAE 420 Query: 441 CKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSE 500 CKE+W +GP+EY+ +LWN+LDFGML+IF A+F ARF+AF A+KAQ +D+ DL++ Sbjct: 421 CKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTK 480 Query: 501 VTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGR 560 VTL ++Y+ AR KW P+DPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGR Sbjct: 481 VTLGDNVKYYNLARIKWDPTDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGR 540 Query: 561 TVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVT 620 TVKDIFKFMV+FIMVF AFMIGMF LYSYY+GAK N AFTTVEESFKTLFW+IFGLSEV Sbjct: 541 TVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVK 600 Query: 621 SVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKL 680 SVV+ Y+HKFIENIGYVLYG+YNVTMV+VLLNMLIAMINSS+QEIEDD+DVEWKFAR+KL Sbjct: 601 SVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKL 660 Query: 681 WLSYFDDGKTLPPPFSLVPSP----KSFVYFIMRIVNFPKCRRRRLQKDIEM-------- 728 W SYF++G+TLP PF+LVPSP + F + + +++ Q+D EM Sbjct: 661 WFSYFEEGRTLPVPFNLVPSPKSLLYLLLKFKKWMCELIQGQKQGFQEDAEMNKRNEEKK 720 Query: 729 -GMGNSKSRLNLFT----------QSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLK 777 G+ S L+ F+ QS++R E + NS N P +YQ+IMKRLIKRYVL+ Sbjct: 721 FGISGSHEDLSKFSLDKNQLAHNKQSSTRSSEDYHLNSFSNPPRQYQKIMKRLIKRYVLQ 780 Query: 778 AQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLN 829 AQ+DKE+DEVNEGELKEIKQDISSLRYELLE+KSQ TE+LA LI KL E+L+ Sbjct: 781 AQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRKLGERLS 832 >6G1K-A nrPDB Length = 921 Score = 906 bits (2340), Expect = 0.0, Method: Composition-based stats. Identities = 314/802 (39%), Positives = 457/802 (56%), Gaps = 94/802 (11%) Query: 22 TSLTAEEERFLDAAEYGNIPVVRKMLEESK---TLNVNCVDYMGQNALQLAVGNEHLEVT 78 + L+ +E+ +L A E G+ V+ LEE++ +N+NC+D +G+ AL +A+ NE+LE+ Sbjct: 27 SELSTQEKSYLSAVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAIENENLEII 86 Query: 79 ELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAY 138 ELLL +GDALL AI K V VE +LNH + K++ +++ D Sbjct: 87 ELLLSFN--VYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSD------ 138 Query: 139 DEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSH 198 F+PDITPIILAAH YE++ ML+ KG + +PH+ C C +C+ DS H Sbjct: 139 ------FTPDITPIILAAHTNNYEIIKMLVQKGVSVPQPHEVRCNCVECVSSSDVDSLRH 192 Query: 199 SRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFV 258 SRSR+N YK LASP+ ++LSSEDP LTA +LS EL +L+ +E EFK +Y +LS QCK F Sbjct: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKAEYEELSHQCKHFA 252 Query: 259 VGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQL 318 +LD R S E+E ILN L L+R+KLAIKY K+FVA PNCQQ L Sbjct: 253 KDLLDQTRSSRELELILN--FRDDMNLLQDEANNELARLKLAIKYRQKEFVAQPNCQQLL 310 Query: 319 LTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHA 378 + WY+ G R + A K + + + L P L++ Y +AP SR G +R PF+KF+ H Sbjct: 311 ASRWYDEFPGWRRRHWAGKLITCVFIGLMFPLLSLCYLVAPKSRYGLFIRKPFIKFICHT 370 Query: 379 ASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMW 438 AS++ FL LL+ + V++ P + TT E +I+ WVLG +W Sbjct: 371 ASYLTFLFLLLLASQH-----------IVSNNPDRQGPKPTT----VEWMILPWVLGFIW 415 Query: 439 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 498 +E K++W G ++YI WN++DF M S+++A + + +A+++ + + Sbjct: 416 TEIKQMWDGGFQDYIHDWWNLMDFVMNSLYLATISLKIVAYVKYSGCK------------ 463 Query: 499 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 558 RD W P +++E ++AIA + S R+ + AN GPLQISL Sbjct: 464 --------------PRDTWEMWHPTLVAEAVFAIANIFSSLRLISLFTANSHLGPLQISL 509 Query: 559 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYY-----------LGAKVNAAFTTVEESFK 607 GR + DI KF+ ++ +V AF G+ LY YY + N AF+T+ E+ + Sbjct: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYENSEGMTCKGIRCERQNNAFSTLFETLQ 569 Query: 608 TLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIED 667 +LFWSIFGL + +K DHKF E +G ++G YNV +VVLLNMLIAM+N+SYQ I D Sbjct: 570 SLFWSIFGLISLYVTNVKADHKFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQHIAD 629 Query: 668 DSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRI-VNFPKCRRRRLQKDI 726 +D+EWKFAR+KLW+SYF++G TLPPPF+++PSPKS Y I I V+ K R +R + Sbjct: 630 HADIEWKFARTKLWMSYFEEGGTLPPPFNIIPSPKSICYLITWIKVHVFKRRSKRTET-- 687 Query: 727 EMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDE 786 F R E+ N +YQ++++ L+KRYV D + +E Sbjct: 688 -------------FGTLGRRAAENVRLNH------QYQEVLRNLVKRYVAAMIRDAKTEE 728 Query: 787 -VNEGELKEIKQDISSLRYELL 807 + E KE+KQDISS RYE++ Sbjct: 729 GLTEENFKELKQDISSFRYEVI 750 >5Z96-A nrPDB Length = 755 Score = 881 bits (2276), Expect = 0.0, Method: Composition-based stats. Identities = 309/801 (38%), Positives = 460/801 (57%), Gaps = 91/801 (11%) Query: 22 TSLTAEEERFLDAAEYGNIPVVRKMLEESK---TLNVNCVDYMGQNALQLAVGNEHLEVT 78 + L+ E+ +L+A E G+ V+K LEE++ +N+NC+D +G+ AL +A+ NE+LE+ Sbjct: 27 SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86 Query: 79 ELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAY 138 ELLL +GDALL AI K V VE +LNH + K++ +++ Sbjct: 87 ELLLSFN--VYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQF-------- 136 Query: 139 DEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSH 198 + F+PDITPIILAAH YE++ +L+ KG + RPH+ C C +C+ DS H Sbjct: 137 ----SEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192 Query: 199 SRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFV 258 SRSR+N YK LASP+ ++LSSEDP LTA +LS EL +L+ +E EFK++Y +LS QCK F Sbjct: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252 Query: 259 VGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQL 318 +LD R S E+E ILN +++ L + L+R+KLAIKY K+FVA PNCQQ L Sbjct: 253 KDLLDQTRSSRELEIILNYRDDNS--LIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLL 310 Query: 319 LTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHA 378 + WY+ G R + A+K + ++ L P ++ Y IAP S LG +R PF+KF+ H Sbjct: 311 ASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHT 370 Query: 379 ASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMW 438 AS++ FL LL+ + +I +D +Q T E +I+ WVLG +W Sbjct: 371 ASYLTFLFLLLLASQ----------HIDRSDLNRQ-----GPPPTIVEWMILPWVLGFIW 415 Query: 439 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 498 E K++W G ++YI WN++DF M S+++A + + +AF++ + Sbjct: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALN------------ 463 Query: 499 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 558 R+ W P +++E L+AIA + S R+ + AN GPLQISL Sbjct: 464 --------------PRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509 Query: 559 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYY-----------LGAKVNAAFTTVEESFK 607 GR + DI KF+ ++ +V AF G+ LY YY K N AF+T+ E+ + Sbjct: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIRCEKQNNAFSTLFETLQ 569 Query: 608 TLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIED 667 +LFWSIFGL + +K H+F E +G ++G YNV +VVLLNMLIAM+N+SYQ I D Sbjct: 570 SLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIAD 629 Query: 668 DSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIE 727 +D+EWKFAR+KLW+SYF++G TLP PF+++PSPKS Y + I C+++ +K Sbjct: 630 HADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLVKWIWTH-LCKKKMRRKPES 688 Query: 728 MGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDE- 786 G ++ N L + +YQ++M+ L+KRYV + + +E Sbjct: 689 FGTIGRRAADN------------------LRRHHQYQEVMRNLVKRYVAAMIREAKTEEG 730 Query: 787 VNEGELKEIKQDISSLRYELL 807 + E +KE+KQDISS R+E+L Sbjct: 731 LTEENVKELKQDISSFRFEVL 751 >6DJS-A nrPDB Length = 676 Score = 465 bits (1196), Expect = e-131, Method: Composition-based stats. Identities = 299/299 (100%), Positives = 299/299 (100%) Query: 1 MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDY 60 MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDY Sbjct: 18 MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDY 77 Query: 61 MGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKR 120 MGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKR Sbjct: 78 MGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKR 137 Query: 121 LTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDY 180 LTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDY Sbjct: 138 LTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDY 197 Query: 181 FCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIE 240 FCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIE Sbjct: 198 FCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIE 257 Query: 241 KEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKL 299 KEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKL Sbjct: 258 KEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKL 316 Score = 137 bits (344), Expect = 2e-32, Method: Composition-based stats. Identities = 76/76 (100%), Positives = 76/76 (100%) Query: 761 TRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAIL 820 TRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAIL Sbjct: 601 TRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAIL 660 Query: 821 IHKLSEKLNPSMLRCE 836 IHKLSEKLNPSMLRCE Sbjct: 661 IHKLSEKLNPSMLRCE 676 >6BPQ-A nrPDB Length = 950 Score = 342 bits (878), Expect = 3e-94, Method: Composition-based stats. Identities = 106/477 (22%), Positives = 187/477 (39%), Gaps = 77/477 (16%) Query: 224 LTALELSNELAKLANIEKEFKN--DYRKLSMQCKDFVVGVLDLCRDSEE--VEAILNGDL 279 L AL S L +A ++ + + +L+ + + V + C ++E E +L Sbjct: 464 LAALGASKLLKSMAKVKNDINAAGESEELANEYETRAVELFTECYSNDEDLAEQLLTYSC 523 Query: 280 ESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCL 339 E + ++LA++ ++F+A P Q L WY +S + I CL Sbjct: 524 E---------AWGGSNCLELAVEARDQQFIAQPGVQNFLSKQWYGEISRDTKNWKIILCL 574 Query: 340 VVLVVALGLPFLAIGYWIAPCSRLGK-------ILRSPFMKFVAHAASFIIFLGLLVFNA 392 + +G F I + P + K SPF+ F + +I FL L + Sbjct: 575 FFFPL-IGCGF--ISFRKKPVEKTKKLFLYYVSFFTSPFVVFSWNVIFYIAFLLLFAY-- 629 Query: 393 SDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREY 452 + + D+ K+ T E+++ V V ++ E ++ ++ G + Y Sbjct: 630 ------------VLLMDFQKEP--------TALEIILYVLVFILLCDEVRQWYMNGSK-Y 668 Query: 453 ILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTY 512 LWNV+D + FIA R L + ++ Y + D TL I FT Sbjct: 669 FSDLWNVMDTLAIFYFIAGIVFR----LHSDESSWYSGRVIFCLDYIVFTLRL-IHIFTV 723 Query: 513 ARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLF 572 +R+ P+II I V A + A FG + + R K+ ++ +F Sbjct: 724 SRNL----GPKIIMLQRMMIDVFFFLFLFAVWMVA---FGVARQGILR--KNEHRWEWIF 774 Query: 573 IMVFFAFMIGMFILYSYYL-GAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHK-- 629 V + + MF Y + G N T F +E + ++ D Sbjct: 775 RSVIYEPYLAMFGQYPDDIDGTTYNFDHCT------------FSGNESKPLCVELDANNQ 822 Query: 630 --FIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSY 684 F E I L IY ++ ++L+N+L+AM + +++++D WKF R L Y Sbjct: 823 PRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGSVQENNDQVWKFQRFFLVQEY 879 >6DU8-A nrPDB Length = 805 Score = 271 bits (692), Expect = 1e-72, Method: Composition-based stats. Identities = 77/334 (23%), Positives = 144/334 (43%), Gaps = 51/334 (15%) Query: 354 GYWIA-PCSRLG--KILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTL----PNIT 406 GY++ P SR G + LR+ + ++F+ V+NA+ + L P Sbjct: 269 GYYLDLPGSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRLVVEFPATG 328 Query: 407 VTDYPKQIFRVKTTQF--TW------TEMLIMVWVLGMMWSECKELWLEGPREYILQLWN 458 QI VK ++ W E++ V++ + E EL + R Y+ +WN Sbjct: 329 GAIPSWQIRTVKLIRYVSNWDFFIVGCEVIFCVFIFYYVVEEILELHIHRLR-YLSSIWN 387 Query: 459 VLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWL 518 +LD L + + + A + + + + +Q+ + TYA ++L Sbjct: 388 ILD---LVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPN-------------TYADFEFL 431 Query: 519 PSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFA 578 + Q + A+ + ++ +I + N++ L +L R KDI F V+F +VFFA Sbjct: 432 -AFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFA 490 Query: 579 FMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVL 638 + ++L F T E+F T IF ++ ++ +D+ I+N +L Sbjct: 491 YAQLGYLL------------FGTQVENFSTFIKCIF--TQFRIILGDFDYNAIDNANRIL 536 Query: 639 YGI----YNVTMVVVLLNMLIAMINSSYQEIEDD 668 Y + VLLNM +A+IN +Y E++++ Sbjct: 537 GPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKEE 570 >5Z1W-A nrPDB Length = 566 Score = 264 bits (675), Expect = 1e-70, Method: Composition-based stats. Identities = 77/334 (23%), Positives = 143/334 (42%), Gaps = 51/334 (15%) Query: 354 GYWIA-PCSRLG--KILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTL----PNIT 406 GY++ P SR + L+ + ++F+ V+NA+ I L P Sbjct: 206 GYYLDLPGSRQASAEALQGLQEGLWLDRGTRVVFIDFSVYNANINLFCILRLVVEFPATG 265 Query: 407 VTDYPKQIFRVKTTQF--TW------TEMLIMVWVLGMMWSECKELWLEGPREYILQLWN 458 T QI VK ++ W E++ V++ + E E+ L R Y+ +WN Sbjct: 266 GTIPSWQIRTVKLIRYVNNWDFFIVGCEVVFCVFIFYYVVEEILEIHLHRLR-YLSSVWN 324 Query: 459 VLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWL 518 +LD L + + + A + + + + +Q+ D TYA ++L Sbjct: 325 ILD---LVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPD-------------TYADFEFL 368 Query: 519 PSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFA 578 + Q + A+ + ++ +I + N++ L +L R KDI F ++F +VFFA Sbjct: 369 -AFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFA 427 Query: 579 FMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVL 638 + ++L F T E+F T IF ++ ++ +D+ I+N +L Sbjct: 428 YAQLGYLL------------FGTQVENFSTFVKCIF--TQFRIILGDFDYNAIDNANRIL 473 Query: 639 YG----IYNVTMVVVLLNMLIAMINSSYQEIEDD 668 Y + VLLNM +A+IN +Y E++++ Sbjct: 474 GPVYFVTYVFFVFFVLLNMFLAIINDTYSEVKEE 507 >6BWF-A nrPDB Length = 954 Score = 235 bits (600), Expect = 4e-62, Method: Composition-based stats. Identities = 62/377 (16%), Positives = 138/377 (36%), Gaps = 83/377 (22%) Query: 366 ILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWT 425 +P +KF + +++ FL L F + E + + Sbjct: 502 FYHAPIVKFWFNTLAYLGFLMLYTFVVLVKMEQL----------------------PSVQ 539 Query: 426 EMLIMVWVLGMMWSECKELWL-------EGPREYILQLWNVLDFGMLSIFIAAFTARFLA 478 E +++ ++ + +E+++ + + + +NV D + F F RF A Sbjct: 540 EWIVIAYIFTYAIEKVREVFMSEAGKISQKIKVWFSDYFNVSDTIAIISFFVGFGLRFGA 599 Query: 479 FLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSF 538 A + F R +Y + ++ + Sbjct: 600 KWNYINA-------------------YDNHVFVAGRL-------------IYCLNIIFWY 627 Query: 539 SRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGM-FILYSYYLGAKVNA 597 R+ L N+ GP + +G+ V ++F +V+ +V +F + ILY + Sbjct: 628 VRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHE-----EP 682 Query: 598 AFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIE-------NIGYVLYGIYNVTMVVVL 650 +++ ++ +W IFG + + + + + L +Y +++ Sbjct: 683 SWSLAKDIVFHPYWMIFGEVYAYEIDVCANDSTLPTICGPGTWLTPFLQAVYLFVQYIIM 742 Query: 651 LNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMR 710 +N+LIA N+ Y +++ S++ WK+ R ++Y + LPPP ++ S + Sbjct: 743 VNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAY-HEKPVLPPPLIILSHIVSLFCCV-- 799 Query: 711 IVNFPKCRRRRLQKDIE 727 C+RR+ K + Sbjct: 800 ------CKRRKKDKTSD 810 >6MWQ-A nrPDB Length = 493 Score = 221 bits (563), Expect = 8e-58, Method: Composition-based stats. Identities = 65/249 (26%), Positives = 101/249 (40%), Gaps = 46/249 (18%) Query: 21 GTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTEL 80 G+ L ++ L+AA G VR ++ + +VN +D G L LA HLE+ E+ Sbjct: 2 GSDLG---KKLLEAARAGQDDEVRILM--ANGADVNALDRFGLTPLHLAAQRGHLEIVEV 56 Query: 81 LLKKENLARIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDF 135 LLK D L LA + G++ IVE +L + D Sbjct: 57 LLKCGADVNAADLWGQTPLHLAATAGHLEIVEVLLKYGA-------------------DV 97 Query: 136 YAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCG-DCMEKQRHD 194 A D G TP+ L A E+V +LL GA + D F K D ++ Sbjct: 98 NALDLIGK------TPLHLTAIDGHLEIVEVLLKHGADV-NAQDKFGKTAFDISIDNGNE 150 Query: 195 SFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAK-LANIEKEFKND----YRK 249 + ++N L+ A+ ++ +L A E + +AK L +I E + YR+ Sbjct: 151 DLAEILQKLN----LSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQ 206 Query: 250 LSMQCKDFV 258 L + D V Sbjct: 207 LLLTADDRV 215 >5MKE-A nrPDB Length = 968 Score = 201 bits (511), Expect = 9e-52, Method: Composition-based stats. Identities = 65/343 (18%), Positives = 123/343 (35%), Gaps = 52/343 (15%) Query: 345 ALGLPFLAIGYWIA---PCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITT 401 + + GY++ + S + F+ V+NA+ + Sbjct: 381 GIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVR 440 Query: 402 L----PNITVTDYPKQIFRVKTTQF--------TWTEMLIMVWVLGMMWSECKELWLEGP 449 L P Q +K ++ E++ ++ + E E+ + Sbjct: 441 LLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKL 500 Query: 450 REYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQY 509 Y WN LD ++ + + A + + EV L Sbjct: 501 H-YFRSFWNCLDVVIVVLSVVAI-----------------GINIYRTSNVEVLLQFLEDQ 542 Query: 510 FTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFM 569 T+ + L + QI + A+ V + ++ + N + L ++ R KD+F F Sbjct: 543 NTFPNFEHL-AYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFA 601 Query: 570 VLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHK 629 ++F ++F A+ ++++ G +V+ F+T +E T F I G Sbjct: 602 IMFFIIFLAYAQLAYLVF----GTQVD-DFSTFQECIFTQFRIILGDINFAE-------- 648 Query: 630 FIENIGYVLYGIY----NVTMVVVLLNMLIAMINSSYQEIEDD 668 IE VL IY M +LLNM +A+IN +Y E++ D Sbjct: 649 -IEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSD 690 >6D1W-A nrPDB Length = 740 Score = 195 bits (495), Expect = 8e-50, Method: Composition-based stats. Identities = 64/343 (18%), Positives = 122/343 (35%), Gaps = 52/343 (15%) Query: 345 ALGLPFLAIGYWIA---PCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITT 401 + + GY++ + S + F+ V+NA+ + Sbjct: 329 GIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVR 388 Query: 402 L----PNITVTDYPKQIFRVKTTQF--------TWTEMLIMVWVLGMMWSECKELWLEGP 449 L P Q +K ++ E++ ++ + E E+ + Sbjct: 389 LLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKL 448 Query: 450 REYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQY 509 Y WN LD ++ + + A + + EV L Sbjct: 449 H-YFRSFWNCLDVVIVVLSVVAI-----------------GINIYRTSNVEVLLQFLEDQ 490 Query: 510 FTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFM 569 T+ + L + QI + A+ V + ++ + N + L ++ R KD+F F Sbjct: 491 NTFPNFEHL-AYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFA 549 Query: 570 VLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHK 629 ++ ++F A+ ++++ G +V+ F+T +E T F I G Sbjct: 550 IMPFIIFLAYAQLAYLVF----GTQVD-DFSTFQECIFTQFRIILGDINFAE-------- 596 Query: 630 FIENIGYVLYGIY----NVTMVVVLLNMLIAMINSSYQEIEDD 668 IE VL IY M +LLNM +A+IN +Y E++ D Sbjct: 597 -IEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSD 638 >5T4D-A nrPDB Length = 510 Score = 195 bits (494), Expect = 1e-49, Method: Composition-based stats. Identities = 65/343 (18%), Positives = 123/343 (35%), Gaps = 52/343 (15%) Query: 345 ALGLPFLAIGYWIA---PCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITT 401 + + GY++ + S + F+ V+NA+ + Sbjct: 189 GIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVR 248 Query: 402 L----PNITVTDYPKQIFRVKTTQF--------TWTEMLIMVWVLGMMWSECKELWLEGP 449 L P Q +K ++ E++ ++ + E E+ + Sbjct: 249 LLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKL 308 Query: 450 REYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQY 509 Y WN LD ++ + + A + + EV L Sbjct: 309 H-YFRSFWNCLDVVIVVLSVVAI-----------------GINIYRTSNVEVLLQFLEDQ 350 Query: 510 FTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFM 569 T+ + L + QI + A+ V + ++ + N + L ++ R KD+F F Sbjct: 351 NTFPNFEHL-AYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFA 409 Query: 570 VLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHK 629 ++F ++F A+ ++++ G +V+ F+T +E T F I G Sbjct: 410 IMFFIIFLAYAQLAYLVF----GTQVD-DFSTFQECIFTQFRIILGDINFAE-------- 456 Query: 630 FIENIGYVLYGIY----NVTMVVVLLNMLIAMINSSYQEIEDD 668 IE VL IY M +LLNM +A+IN +Y E++ D Sbjct: 457 -IEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSD 498 >5H76-A nrPDB Length = 201 Score = 174 bits (441), Expect = 1e-43, Method: Composition-based stats. Identities = 49/179 (27%), Positives = 70/179 (39%), Gaps = 35/179 (19%) Query: 29 ERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLA 88 + L+AA G VR ++ + +VN D G L LA + HLE+ E+LLK Sbjct: 8 RKLLEAARAGQDDEVRILM--ANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADV 65 Query: 89 RIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGT 143 D L LA G++ IVE +L + D A D DG Sbjct: 66 DASDVFGYTPLHLAAYWGHLEIVEVLLKNGA-------------------DVNAMDSDG- 105 Query: 144 RFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCG-DCMEKQRHDSFSHSRS 201 +TP+ LAA E+V +LL GA D F K D ++ + + Sbjct: 106 -----MTPLHLAAKWGYLEIVEVLLKHGA--VNAQDKFGKTAFDISIDNGNEDLAQILA 157 >5AQ9-A nrPDB Length = 422 Score = 172 bits (436), Expect = 5e-43, Method: Composition-based stats. Identities = 52/187 (27%), Positives = 73/187 (39%), Gaps = 37/187 (19%) Query: 21 GTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTEL 80 G+ L + L+AA G VR ++ + +VN D G L LA + HLE+ E+ Sbjct: 11 GSDLG---RKLLEAARAGQDDEVRILM--ANGADVNAADNTGTTPLHLAAYSGHLEIVEV 65 Query: 81 LLKKENLARIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDF 135 LLK D L LA G++ IVE +L + D Sbjct: 66 LLKHGADVDASDVFGYTPLHLAAYWGHLEIVEVLLKNGA-------------------DV 106 Query: 136 YAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCG-DCMEKQRHD 194 A D DG +TP+ LAA E+V +LL GA + D F K D + +D Sbjct: 107 NAMDSDG------MTPLHLAAKWGYLEIVEVLLKHGADV-NAQDKFGKTPFDLADDNGND 159 Query: 195 SFSHSRS 201 Sbjct: 160 DVGTLLQ 166 Score = 39.4 bits (90), Expect = 0.007, Method: Composition-based stats. Identities = 25/87 (28%), Positives = 37/87 (42%), Gaps = 11/87 (12%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDA 93 AA++G + +V +L+ +VN D G+ LA N + +V LL +A D Sbjct: 120 AAKWGYLEIVEVLLK--HGADVNAQDKFGKTPFDLADDNGNDDVGTLL----QVAAAADQ 173 Query: 94 LLLAISKGYVRIVEAILNHPGFAASKR 120 L GY +E LN S R Sbjct: 174 L--GARVGY---IELDLNSGKILESFR 195 >5MIO-C nrPDB Length = 573 Score = 171 bits (434), Expect = 8e-43, Method: Composition-based stats. Identities = 49/183 (26%), Positives = 69/183 (37%), Gaps = 34/183 (18%) Query: 29 ERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLA 88 ++ L+AA G VR ++ + +VN D G L LA HLE+ E+LLK Sbjct: 412 KKLLEAARAGQDDEVRVLM--ANGADVNATDASGLTPLHLAATYGHLEIVEVLLKHGADV 469 Query: 89 RIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGT 143 D L LA G++ IVE +L H D A D G Sbjct: 470 SASDLMGSTPLHLAALIGHLEIVEVLLKHGA-------------------DVNAVDTWGD 510 Query: 144 RFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCG-DCMEKQRHDSFSHSRSR 202 TP+ LAA ++V LL GA + D F K D + + + Sbjct: 511 ------TPLRLAAVMGHLKIVEALLKHGADV-NAQDKFGKTAYDTSIDNGSEDLAEILQK 563 Query: 203 INA 205 +N Sbjct: 564 LNL 566 >5AQA-A nrPDB Length = 418 Score = 163 bits (412), Expect = 3e-40, Method: Composition-based stats. Identities = 56/203 (27%), Positives = 82/203 (40%), Gaps = 40/203 (19%) Query: 21 GTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTEL 80 G+ L + L+AA G VR ++ + +VN D G L LA + HLE+ E+ Sbjct: 11 GSDLG---RKLLEAARAGQDDEVRILM--ANGADVNAADNTGTTPLHLAAYSGHLEIVEV 65 Query: 81 LLKKENLARIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDF 135 LLK D L LA G++ IVE +L + D Sbjct: 66 LLKHGADVDASDVFGYTPLHLAAYWGHLEIVEVLLKNGA-------------------DV 106 Query: 136 YAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCK-CGDCMEKQRHD 194 A D DG +TP+ LAA E+V +LL GA ++ D F K Q H Sbjct: 107 NAMDSDG------MTPLHLAAKWGYKEIVEVLLKAGADVD-AQDKFGKRPLWLAADQGH- 158 Query: 195 SFSHSRSRINAYKGLASPAYLSL 217 + +++ A + A Y+ L Sbjct: 159 --AEIAAKLVAARLKARVGYIEL 179 >5AQB-A nrPDB Length = 428 Score = 146 bits (367), Expect = 5e-35, Method: Composition-based stats. Identities = 49/188 (26%), Positives = 73/188 (38%), Gaps = 38/188 (20%) Query: 21 GTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTEL 80 G+ L ++ L+AA G R ++ + +VN +D +G L LA HLE+ E Sbjct: 11 GSDLG---KKLLEAARAGQDDECRILM--ANGADVNALDEVGWTPLHLAAW-GHLEIVEC 64 Query: 81 LLKKENLARIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDF 135 LLK D L LA G++ IVE +L + D Sbjct: 65 LLKNGADVNAADIDGYTPLHLAAFSGHLEIVEVLLKYGA-------------------DV 105 Query: 136 YAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCG-DCMEKQRHD 194 A D+ G TP+ LAA E+V +LL GA + D F K D ++ Sbjct: 106 NADDQAG------FTPLHLAAIFGHLEIVEVLLKNGADV-NAQDKFGKTPRDLAIDNGNE 158 Query: 195 SFSHSRSR 202 + + Sbjct: 159 DIAEVLGK 166 >6FES-A nrPDB Length = 367 Score = 139 bits (350), Expect = 4e-33, Method: Composition-based stats. Identities = 49/180 (27%), Positives = 68/180 (37%), Gaps = 34/180 (18%) Query: 29 ERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLA 88 ++ L+AA G VR +L + +VN D G L LA HL + E+LLK Sbjct: 8 KKLLEAARAGQDDEVRILL--ANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADV 65 Query: 89 RIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGT 143 D L LA G++ IVE +L + A D GT Sbjct: 66 NANDERGHTPLHLAAYTGHLEIVEVLLKNGA-------------------GVNATDVIGT 106 Query: 144 RFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKC-GDCMEKQRHDSFSHSRSR 202 P+ LAA E+V +LL GA R D F K D ++S + + Sbjct: 107 ------APLHLAAMWGHEEIVEVLLKNGADA-RAQDKFGKTPEDLARDNGYESVARLARK 159 >5AQ7-A nrPDB Length = 418 Score = 138 bits (348), Expect = 8e-33, Method: Composition-based stats. Identities = 54/203 (26%), Positives = 78/203 (38%), Gaps = 40/203 (19%) Query: 21 GTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTEL 80 G+ L ++ L+AA G VR +L + +VN D G L LA HL + E+ Sbjct: 11 GSDLG---KKLLEAARAGQDDEVRILL--ANGADVNTADETGFTPLHLAAWEGHLGIVEV 65 Query: 81 LLKKENLARIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDF 135 LLK D L LA G++ IVE +L + Sbjct: 66 LLKNGADVNANDERGHTPLHLAAYTGHLEIVEVLLKNGA-------------------GV 106 Query: 136 YAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCK-CGDCMEKQRHD 194 A D GT P+ LAA E+V +LL GA ++ D F K Q H Sbjct: 107 NATDVIGT------APLHLAAMWGYKEIVEVLLKAGADVD-AQDKFGKRPLWLAADQGH- 158 Query: 195 SFSHSRSRINAYKGLASPAYLSL 217 + +++ A + A Y+ L Sbjct: 159 --AEIAAKLVAARLKARVGYIEL 179 >5CBO-A nrPDB Length = 176 Score = 115 bits (288), Expect = 8e-26, Method: Composition-based stats. Identities = 37/181 (20%), Positives = 57/181 (31%), Gaps = 57/181 (31%) Query: 29 ERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLA 88 ++ L+AA G VR ++ + +VN +D G Sbjct: 5 KKLLEAAHAGQDDEVRILM--ANGADVNAMDNFGVTP----------------------- 39 Query: 89 RIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPD 148 L LA G+ IVE +L + D A D G Sbjct: 40 -----LHLAAYWGHFEIVEVLLKYGA-------------------DVNASDATGD----- 70 Query: 149 ITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCG-DCMEKQRHDSFSHSRSRINAYK 207 TP+ LAA +V +LL GA + D F K D ++ + + A + Sbjct: 71 -TPLHLAAKWGYLGIVEVLLKYGADV-NAQDKFGKTAFDISIDNGNEDLAEILCKNKAQQ 128 Query: 208 G 208 Sbjct: 129 A 129 Score = 38.6 bits (88), Expect = 0.012, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 32/63 (50%), Gaps = 2/63 (3%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDA 93 AA++G + +V +L+ +VN D G+ A +++ N + ++ E+L K + Sbjct: 76 AAKWGYLGIVEVLLKY--GADVNAQDKFGKTAFDISIDNGNEDLAEILCKNKAQQAAFYC 133 Query: 94 LLL 96 +L Sbjct: 134 ILH 136 >6BWI-A nrPDB Length = 977 Score = 104 bits (258), Expect = 2e-22, Method: Composition-based stats. Identities = 54/299 (18%), Positives = 103/299 (34%), Gaps = 42/299 (14%) Query: 421 QFTWTEMLIMVWVLGMMWSECKELWL-------------------EGPREYILQLWNVLD 461 E+L+ W ++ E ++ + R Y+ WN D Sbjct: 610 PPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCD 669 Query: 462 FGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSD 521 L+ F+ R L ++ V D T+ + FT + Sbjct: 670 LVALTCFLLGVGCRLTPGL------YHLGRTVLCIDFMVFTVRL-LHIFTVNKQL----G 718 Query: 522 PQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMI 581 P+I+ V + L A +G L R F + VF+ + Sbjct: 719 PKIVIVSKMMKDVFFFLFFLGVWLVA---YGVATEGLLRPRDS--DFPSILRRVFYRPYL 773 Query: 582 GMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGI 641 +F + S + FW+ ++ + V +Y + +L I Sbjct: 774 QIFGQIPQEDMDVALMEHSNC--SSEPGFWAHPPGAQAGTCVSQY----ANWLVVLLLVI 827 Query: 642 YNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPS 700 + + ++L+N+LIAM + ++ +++ +SD+ WK R +L F L PPF ++ Sbjct: 828 FLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIRE-FHSRPALAPPFIVISH 885 Score = 40.6 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 19/114 (16%), Positives = 42/114 (36%), Gaps = 9/114 (7%) Query: 233 LAKLANIEKEFKNDYRK--LSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRH 290 L +A +E + + R+ L+ + + V + C S EV A + L Sbjct: 397 LRVMARLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRA-------ARLLLRRCPL 449 Query: 291 KASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVV 344 + ++LA++ + + F A Q L W+ +++ + + Sbjct: 450 WGDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCPPL 503 >4Z68-A nrPDB Length = 155 Score = 91.4 bits (225), Expect = 1e-18, Method: Composition-based stats. Identities = 39/178 (21%), Positives = 62/178 (34%), Gaps = 37/178 (20%) Query: 25 TAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQ--NALQLAVGNEHLEVTELLL 82 + + + L+AA+ G++ V+K+ +VNC D G+ L A G + V E LL Sbjct: 1 SEADRQLLEAAKAGDVETVKKL---CTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLL 57 Query: 83 KKENLARIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYA 137 + D L A S G+ + E ++ H Sbjct: 58 QHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAV-------------------VNV 98 Query: 138 YDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKC-GDCMEKQRHD 194 D TP+ AA KYE+ +LL GA + D ++ D Sbjct: 99 ADLW------KFTPLHEAAAKGKYEICKLLLQHGAD-PTKKNRDGNTPLDLVKDGDTD 149 Score = 68.7 bits (166), Expect = 1e-11, Method: Composition-based stats. Identities = 30/111 (27%), Positives = 44/111 (39%), Gaps = 7/111 (6%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD- 92 AA Y + VV +L+ +V+ D G L A H EV ELL+K + + D Sbjct: 44 AAGYNRVSVVEYLLQ--HGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADL 101 Query: 93 ----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYD 139 L A +KG I + +L H K + ++D D D Sbjct: 102 WKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQD 152 >5JHQ-A nrPDB Length = 482 Score = 85.3 bits (209), Expect = 1e-16, Method: Composition-based stats. Identities = 42/159 (26%), Positives = 58/159 (36%), Gaps = 37/159 (23%) Query: 24 LTAEEER--FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQ--NALQLAVGNEHLEVTE 79 LT E ++ L+AA GN K++ LNVNC G+ L LA G + + + Sbjct: 163 LTGEYKKDELLEAARSGNEE---KLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQ 219 Query: 80 LLLKKENLARIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDD 134 LLL+ D L A S G+ + E +L H Sbjct: 220 LLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC------------------- 260 Query: 135 FYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGAR 173 A D TP+ AA + EV +LL GA Sbjct: 261 VNAMDLW------QFTPLHEAASKNRVEVCSLLLSHGAD 293 Score = 74.1 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 46/222 (20%), Positives = 77/222 (34%), Gaps = 43/222 (19%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD- 92 AA Y + +V+ +L+ +V+ D G L A H EVTELLLK D Sbjct: 209 AAGYNRVRIVQLLLQ--HGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDL 266 Query: 93 ----ALLLAISKGYVRIVEAILNHPGF--------AASKRLTLSPCEQELQDDDFYAYDE 140 L A SK V + +L+H ++ + +P +E +F + Sbjct: 267 WQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSL 326 Query: 141 DGTRFSPDI---------------------TPIILAA---HCQKYEVVHMLLMKGARIER 176 D+ T + A H ++ +V +LL KGA + Sbjct: 327 LQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNE 386 Query: 177 PHDYFCKCGDCMEKQRHDSFSHSR----SRINAYKGLASPAY 214 + F ++ H+ +++NA L A Sbjct: 387 KNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTAL 428 Score = 73.3 bits (178), Expect = 4e-13, Method: Composition-based stats. Identities = 37/164 (22%), Positives = 58/164 (35%), Gaps = 36/164 (21%) Query: 29 ERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQ--NALQLAVGNEHLEVTELLLKKEN 86 L+A G++ V+++++ + NVN D G+ + L A G +V E LL+ Sbjct: 17 RELLEACRNGDVSRVKRLVDAA---NVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGA 73 Query: 87 LARIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDED 141 D L A S G+ +V +L D A D Sbjct: 74 NVHARDDGGLIPLHNACSFGHAEVVSLLLCQGA-------------------DPNARDNW 114 Query: 142 GTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCG 185 + TP+ AA K +V +LL GA + K Sbjct: 115 ------NYTPLHEAAIKGKIDVCIVLLQHGAD-PNIRNTDGKSA 151 Score = 71.4 bits (173), Expect = 2e-12, Method: Composition-based stats. Identities = 42/179 (23%), Positives = 61/179 (34%), Gaps = 44/179 (24%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD- 92 AA +G VV +L+ NV+ D G L A H EV LLL + D Sbjct: 56 AAGFGRKDVVEHLLQM--GANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDN 113 Query: 93 ----ALLLAISKGYVRIVEAILNHPG-----------------FAASKRLTLSPCEQELQ 131 L A KG + + +L H +A LT + EL Sbjct: 114 WNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELL 173 Query: 132 DD----------------DFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARI 174 + + + DG + TP+ LAA + +V +LL GA + Sbjct: 174 EAARSGNEEKLMALLTPLNVNCHASDGRKS----TPLHLAAGYNRVRIVQLLLQHGADV 228 Score = 47.1 bits (110), Expect = 3e-05, Method: Composition-based stats. Identities = 22/100 (22%), Positives = 40/100 (40%), Gaps = 6/100 (6%) Query: 20 RGTSLTAEEERFLD----AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHL 75 +G ++ + + F+ AAE + V+ + +N +D +GQ AL A HL Sbjct: 380 KGANVNEKNKDFMTPLHVAAERAHNDVMEVL--HKHGAKMNALDTLGQTALHRAALAGHL 437 Query: 76 EVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGF 115 + LLL + I ++ V+ IL+ Sbjct: 438 QTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTP 477 >5HKP-A nrPDB Length = 351 Score = 85.3 bits (209), Expect = 1e-16, Method: Composition-based stats. Identities = 42/159 (26%), Positives = 58/159 (36%), Gaps = 37/159 (23%) Query: 24 LTAEEER--FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQ--NALQLAVGNEHLEVTE 79 LT E ++ L+AA GN K++ LNVNC G+ L LA G + + + Sbjct: 19 LTGEYKKDELLEAARSGNEE---KLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQ 75 Query: 80 LLLKKENLARIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDD 134 LLL+ D L A S G+ + E +L H Sbjct: 76 LLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC------------------- 116 Query: 135 FYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGAR 173 A D TP+ AA + EV +LL GA Sbjct: 117 VNAMDLW------QFTPLHEAASKNRVEVCSLLLSHGAD 149 Score = 74.5 bits (181), Expect = 2e-13, Method: Composition-based stats. Identities = 46/222 (20%), Positives = 77/222 (34%), Gaps = 43/222 (19%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD- 92 AA Y + +V+ +L+ +V+ D G L A H EVTELLLK D Sbjct: 65 AAGYNRVRIVQLLLQ--HGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDL 122 Query: 93 ----ALLLAISKGYVRIVEAILNHPGF--------AASKRLTLSPCEQELQDDDFYAYDE 140 L A SK V + +L+H ++ + +P +E +F + Sbjct: 123 WQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSL 182 Query: 141 DGTRFSPDI---------------------TPIILAA---HCQKYEVVHMLLMKGARIER 176 D+ T + A H ++ +V +LL KGA + Sbjct: 183 LQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVAELLLRKGANVNE 242 Query: 177 PHDYFCKCGDCMEKQRHDSFSHSR----SRINAYKGLASPAY 214 + F ++ H+ +++NA L A Sbjct: 243 KNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDSLGQTAL 284 Score = 47.9 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 24/118 (20%), Positives = 44/118 (37%), Gaps = 6/118 (5%) Query: 20 RGTSLTAEEERFLD----AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHL 75 +G ++ + + F+ AAE + V+ + +N +D +GQ AL A HL Sbjct: 236 KGANVNEKNKDFMTPLHVAAERAHNDVMEVL--HKHGAKMNALDSLGQTALHRAALAGHL 293 Query: 76 EVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDD 133 + LLL + I ++ V+ IL+ + + E D Sbjct: 294 QTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPMRTSDVDYRLLEASKAGD 351 Score = 39.0 bits (89), Expect = 0.008, Method: Composition-based stats. Identities = 19/87 (21%), Positives = 32/87 (36%), Gaps = 10/87 (11%) Query: 88 ARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSP 147 + D A+ G + E + K + L L + + DG + Sbjct: 8 LDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMAL------LTPLNVNCHASDGRKS-- 59 Query: 148 DITPIILAAHCQKYEVVHMLLMKGARI 174 TP+ LAA + +V +LL GA + Sbjct: 60 --TPLHLAAGYNRVRIVQLLLQHGADV 84 >5GP7-A nrPDB Length = 169 Score = 84.9 bits (208), Expect = 1e-16, Method: Composition-based stats. Identities = 41/160 (25%), Positives = 62/160 (38%), Gaps = 35/160 (21%) Query: 21 GTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQ--NALQLAVGNEHLEVT 78 G+ L + LDAA+ G + V+K+ N+NC D G+ L LA G +LEV Sbjct: 3 GSDLLRGDAALLDAAKKGCLARVQKL---CTPENINCRDTQGRNSTPLHLAAGYNNLEVA 59 Query: 79 ELLLKKENLARIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDD 133 E LL+ D L A S G+V I ++ + + Sbjct: 60 EYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKY-------------------NT 100 Query: 134 DFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGAR 173 A D+ TP+ AA + ++ +LL GA Sbjct: 101 CVNATDKWA------FTPLHEAAQKGRTQLCALLLAHGAD 134 Score = 63.3 bits (152), Expect = 5e-10, Method: Composition-based stats. Identities = 27/106 (25%), Positives = 40/106 (37%), Gaps = 8/106 (7%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD- 92 AA Y N+ V +LE +VN D G L A H+++ LL+K D Sbjct: 50 AAGYNNLEVAEYLLE--HGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDK 107 Query: 93 ----ALLLAISKGYVRIVEAILNHPG-FAASKRLTLSPCEQELQDD 133 L A KG ++ +L H + +P + DD Sbjct: 108 WAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADD 153 Score = 41.3 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 17/66 (25%), Positives = 27/66 (40%), Gaps = 5/66 (7%) Query: 117 ASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIER 176 A+K+ L+ ++ ++ D G + TP+ LAA EV LL GA + Sbjct: 16 AAKKGCLARVQKLCTPENINCRDTQGR----NSTPLHLAAGYNNLEVAEYLLEHGADV-N 70 Query: 177 PHDYFC 182 D Sbjct: 71 AQDKGG 76 >6DVZ-A nrPDB Length = 791 Score = 74.1 bits (180), Expect = 3e-13, Method: Composition-based stats. Identities = 30/170 (17%), Positives = 72/170 (42%), Gaps = 6/170 (3%) Query: 517 WLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVK-DIFKFMVLFIMV 575 +L +A+ L ++ + +S G + + + + D+ KF+ ++I+ Sbjct: 538 FLYLFAYKEYLACLVLAMALGWANMLAYTRGFQSMGMYSVMIQKVILHDVLKFLFVYILF 597 Query: 576 FFAFMIGMFILYSYYLGAKVN-AAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENI 634 F + + L K + +++ + ++ LF GL ++ + + Sbjct: 598 LLGFGVALASLIEKCSKDKKDCSSYGSFSDAVLELFKLTIGLGDLNI----QQNSTYPIL 653 Query: 635 GYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSY 684 L Y + V+LLNMLIA++ + + + +S+ W+ R++ L + Sbjct: 654 FLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEF 703 Score = 36.7 bits (83), Expect = 0.041, Method: Composition-based stats. Identities = 36/217 (16%), Positives = 73/217 (33%), Gaps = 53/217 (24%) Query: 6 RRQAVRGPAFMFNDRGTSLTAEE---ERFLDAAEYGNIPVVRKMLEESKTLNV-----NC 57 RR+ + P F+ + S T + + L+ +VR +L ++ ++ N Sbjct: 148 RRRGLDVPDFLMHKLTASDTGKTCLMKALLN-INPNTKEIVRILLAFAEENDILDRFINA 206 Query: 58 V----DYMGQNALQLAVGNEHLEVTELLLKKENLARI-------------------GDAL 94 Y GQ AL +A+ ++T +L+ L Sbjct: 207 EYTEEAYEGQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPL 266 Query: 95 LLAISKGYVRIVEAILNHPGFAASKR----------LTLSPCEQELQDDDFYAY------ 138 LA IV+ ++ + + + L + + Q+D Sbjct: 267 ALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILL 326 Query: 139 -----DEDGTRFSPDITPIILAAHCQKYEVVHMLLMK 170 + + R + +TP+ LAA K E++ +L + Sbjct: 327 RSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSR 363 Score = 33.6 bits (75), Expect = 0.39, Method: Composition-based stats. Identities = 28/135 (20%), Positives = 43/135 (31%), Gaps = 16/135 (11%) Query: 61 MGQNALQLAVGNEH---LEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAA 117 G+ L A+ N + E+ +LL I D + A + LN A Sbjct: 167 TGKTCLMKALLNINPNTKEIVRILLAFAEENDILDRFINAEYTEEAYEGQTALN---IAI 223 Query: 118 SKRLTLSPCEQELQDDDFYAYDEDGTRFSPDI---------TPIILAAHCQKYEVVHMLL 168 +R D A+ G F+P TP+ LAA + E+V +L+ Sbjct: 224 ERRQGDITAVLIAAGADVNAH-AKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLM 282 Query: 169 MKGARIERPHDYFCK 183 D Sbjct: 283 ENEQTDITSQDSRGN 297 >6MHW-A nrPDB Length = 826 Score = 73.7 bits (179), Expect = 3e-13, Method: Composition-based stats. Identities = 33/172 (19%), Positives = 75/172 (43%), Gaps = 10/172 (5%) Query: 517 WLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVK-DIFKFMVLFIMV 575 +L +A+ L ++ + Y +S G + + + + D+ KF+ ++I+ Sbjct: 539 FLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVF 598 Query: 576 FFAFMIGMFILYSYYLGAKVNAA---FTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIE 632 F + + L K N + + ++ LF GL + + ++ + K+ Sbjct: 599 LLGFGVALASLI--EKCPKDNKDCSSYGSFSDAVLELFKLTIGLGD---LNIQQNSKYP- 652 Query: 633 NIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSY 684 + L Y + V+LLNMLIA++ + + + +S+ W+ R++ L + Sbjct: 653 ILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEF 704 Score = 37.1 bits (84), Expect = 0.032, Method: Composition-based stats. Identities = 23/112 (20%), Positives = 43/112 (38%), Gaps = 9/112 (8%) Query: 60 YMGQNALQLAVGNEHLEVTELLLKKE-NLARIGDALLLAISKGYVRIVEAILNHPGFAAS 118 Y G+ L LA E+ +LL++ E D+ I V + E Sbjct: 261 YFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAE--------DFK 312 Query: 119 KRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMK 170 + ++ ++ + TR + +TP+ LAA K E++ +L + Sbjct: 313 TQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSR 364 Score = 32.9 bits (73), Expect = 0.58, Method: Composition-based stats. Identities = 27/135 (20%), Positives = 42/135 (31%), Gaps = 16/135 (11%) Query: 61 MGQNALQLAVGNEH---LEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAA 117 G+ L A+ N + E+ +LL I + A + LN A Sbjct: 168 TGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALN---IAI 224 Query: 118 SKRLTLSPCEQELQDDDFYAYDEDGTRFSPDI---------TPIILAAHCQKYEVVHMLL 168 +R D A+ G F+P TP+ LAA + E+V +L+ Sbjct: 225 ERRQGDIAALLIAAGADVNAH-AKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLM 283 Query: 169 MKGARIERPHDYFCK 183 D Sbjct: 284 EHEQTDITSRDSRGN 298 >6BY9-A nrPDB Length = 328 Score = 73.3 bits (178), Expect = 5e-13, Method: Composition-based stats. Identities = 37/172 (21%), Positives = 63/172 (36%), Gaps = 31/172 (18%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDA 93 AAE G++ + +++ N++ + L A N HLE + L+K L DA Sbjct: 109 AAEAGHVDICHMLVQA--GANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDA 166 Query: 94 -----LLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPD 148 L LA KG+ +V+ +L++ D D+ G Sbjct: 167 EGSTCLHLAAKKGHYEVVQYLLSNG------------------QMDVNCQDDGGW----- 203 Query: 149 ITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSR 200 TP+I A + ++V +LL KG+ I + C + Sbjct: 204 -TPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEIL 254 Score = 67.1 bits (162), Expect = 3e-11, Method: Composition-based stats. Identities = 41/185 (22%), Positives = 69/185 (37%), Gaps = 36/185 (19%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD- 92 AA+ G+ VV+ +L + ++VNC D G + A +H+++ +LLL K + I D Sbjct: 175 AAKKGHYEVVQYLLSNGQ-MDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDN 233 Query: 93 ----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPD 148 L A G V I E +L D +A + G Sbjct: 234 EENICLHWAAFSGCVDIAEILL-------------------AAKCDLHAVNIHGD----- 269 Query: 149 ITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKG 208 +P+ +AA +Y+ V + L + + + + C S S + K Sbjct: 270 -SPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLN-----SQVWSALQMSKA 323 Query: 209 LASPA 213 L A Sbjct: 324 LQDSA 328 Score = 35.9 bits (81), Expect = 0.070, Method: Composition-based stats. Identities = 22/135 (16%), Positives = 34/135 (25%), Gaps = 32/135 (23%) Query: 66 LQLAVGNEHLEVTELLLKKENLARIG-------DALLLAISKGYVRIVEAILNHPGFAAS 118 L + L+ L+L L A G+V I ++ Sbjct: 71 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGA---- 126 Query: 119 KRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPH 178 T TP++ AA E V L+ GA ++ Sbjct: 127 ---------------------NIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKD 165 Query: 179 DYFCKCGDCMEKQRH 193 C K+ H Sbjct: 166 AEGSTCLHLAAKKGH 180 Score = 35.2 bits (79), Expect = 0.14, Method: Composition-based stats. Identities = 21/108 (19%), Positives = 36/108 (33%), Gaps = 9/108 (8%) Query: 100 KGYVRIVEAILNHPGFAA----SKRLTLSPCEQELQDDDFYAYDEDGTRFSPD----ITP 151 K + L+ K+L S + ELQ D F + +P Sbjct: 46 KETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSP 105 Query: 152 IILAAHCQKYEVVHMLLMKGARIER-PHDYFCKCGDCMEKQRHDSFSH 198 + AA ++ HML+ GA I+ D + E ++ + Sbjct: 106 LHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKY 153 >3B7B-A nrPDB Length = 237 Score = 73.3 bits (178), Expect = 5e-13, Method: Composition-based stats. Identities = 37/172 (21%), Positives = 63/172 (36%), Gaps = 31/172 (18%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDA 93 AAE G++ + +++ N++ + L A N HLE + L+K L DA Sbjct: 18 AAEAGHVDICHMLVQA--GANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDA 75 Query: 94 -----LLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPD 148 L LA KG+ +V+ +L++ D D+ G Sbjct: 76 EGSTCLHLAAKKGHYEVVQYLLSNG------------------QMDVNCQDDGGW----- 112 Query: 149 ITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSR 200 TP+I A + ++V +LL KG+ I + C + Sbjct: 113 -TPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEIL 163 Score = 67.1 bits (162), Expect = 3e-11, Method: Composition-based stats. Identities = 41/185 (22%), Positives = 69/185 (37%), Gaps = 36/185 (19%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD- 92 AA+ G+ VV+ +L + ++VNC D G + A +H+++ +LLL K + I D Sbjct: 84 AAKKGHYEVVQYLLSNGQ-MDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDN 142 Query: 93 ----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPD 148 L A G V I E +L D +A + G Sbjct: 143 EENICLHWAAFSGCVDIAEILL-------------------AAKCDLHAVNIHGD----- 178 Query: 149 ITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKG 208 +P+ +AA +Y+ V + L + + + + C S S + K Sbjct: 179 -SPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLN-----SQVWSALQMSKA 232 Query: 209 LASPA 213 L A Sbjct: 233 LQDSA 237 Score = 50.2 bits (118), Expect = 4e-06, Method: Composition-based stats. Identities = 22/122 (18%), Positives = 39/122 (31%), Gaps = 30/122 (24%) Query: 63 QNALQLAVGNEHLEVTELLLKKENLARIGD-----ALLLAISKGYVRIVEAILNHPGFAA 117 ++ L A H+++ +L++ L+ A ++ V+ ++ Sbjct: 12 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 71 Query: 118 SKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERP 177 K D +G+ T + LAA YEVV LL G Sbjct: 72 PK-------------------DAEGS------TCLHLAAKKGHYEVVQYLLSNGQMDVNC 106 Query: 178 HD 179 D Sbjct: 107 QD 108 Score = 34.4 bits (77), Expect = 0.23, Method: Composition-based stats. Identities = 18/101 (17%), Positives = 27/101 (26%), Gaps = 25/101 (24%) Query: 93 ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPI 152 L A G+V I ++ T TP+ Sbjct: 14 PLHAAAEAGHVDICHMLVQAGA-------------------------NIDTCSEDQRTPL 48 Query: 153 ILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRH 193 + AA E V L+ GA ++ C K+ H Sbjct: 49 MEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGH 89 Score = 33.6 bits (75), Expect = 0.32, Method: Composition-based stats. Identities = 11/50 (22%), Positives = 21/50 (42%), Gaps = 1/50 (2%) Query: 150 TPIILAAHCQKYEVVHMLLMKGARIER-PHDYFCKCGDCMEKQRHDSFSH 198 +P+ AA ++ HML+ GA I+ D + E ++ + Sbjct: 13 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKY 62 >4OAU-C nrPDB Length = 699 Score = 69.1 bits (167), Expect = 7e-12, Method: Composition-based stats. Identities = 44/183 (24%), Positives = 80/183 (43%), Gaps = 43/183 (23%) Query: 30 RFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNAL---QLAVGNEHLE-VTELLLKKE 85 +DAAE G++ V++ +L+E +VN D MG+NAL L+ + +E +T LLL Sbjct: 151 ALMDAAEKGHVEVLKILLDEM-GADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHG 209 Query: 86 NLARI-----GDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDE 140 + L+LA+ K ++ +V+ +L E + + D Sbjct: 210 ADVNVRGERGKTPLILAVEKKHLGLVQRLL------------------EQEHIEINDTDS 251 Query: 141 DGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSR 200 DG T ++LA + ++ +L +GA + CGD + R + + HS Sbjct: 252 DGK------TALLLAVELKLKKIAELLCKRGASTD--------CGDLVMTARRN-YDHSL 296 Query: 201 SRI 203 ++ Sbjct: 297 VKV 299 Score = 52.5 bits (124), Expect = 8e-07, Method: Composition-based stats. Identities = 27/100 (27%), Positives = 49/100 (49%), Gaps = 5/100 (5%) Query: 19 DRGTSLTAEEER----FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEH 74 D G + ER + A E ++ +V+++LE+ + +N D G+ AL LAV + Sbjct: 207 DHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEH-IEINDTDSDGKTALLLAVELKL 265 Query: 75 LEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPG 114 ++ ELL K+ GD ++ A +V+ +L+H Sbjct: 266 KKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGA 305 Score = 49.4 bits (116), Expect = 7e-06, Method: Composition-based stats. Identities = 30/150 (20%), Positives = 53/150 (35%), Gaps = 33/150 (22%) Query: 31 FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMG-QNALQLAVGNEHLEVTELLLKKENL-- 87 + A + ++ +V+++LE NVN + G L AV ++ ELLL+ Sbjct: 9 LIKAVQNEDVDLVQQLLEG--GANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPV 66 Query: 88 ---ARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTR 144 +LA G V++++ L+ D D G Sbjct: 67 LRKKNGATPFILAAIAGSVKLLKLFLSKGA-------------------DVNECDFYG-- 105 Query: 145 FSPDITPIILAAHCQKYEVVHMLLMKGARI 174 T + AA K + + L +GA + Sbjct: 106 ----FTAFMEAAVYGKVKALKFLYKRGANV 131 >6BBJ-A nrPDB Length = 868 Score = 68.3 bits (165), Expect = 1e-11, Method: Composition-based stats. Identities = 34/163 (20%), Positives = 66/163 (40%), Gaps = 12/163 (7%) Query: 526 SEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVLFIMVFFAFMIGMF 584 + A+VL + Y + G I L + + KD+F+F++++++ + + Sbjct: 570 YLAVMVFALVLGWMNALYFTRGLKLTGTYSIMLQKILFKDLFRFLLVYLLFMIGYASALV 629 Query: 585 ILY---SYYLGAKVNAAFTTVEE---SFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYV- 637 L + ++ TV E + +S F L + D + I + Y Sbjct: 630 SLLNPCTSQESCIETSSNCTVPEYPSCRDSSTFSKFLLDLFKLTIGMGDLEMINSAKYPA 689 Query: 638 ----LYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFA 676 L Y + V+LLNMLIA++ + ++ +S WK Sbjct: 690 VFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKQIWKLQ 732 Score = 38.6 bits (88), Expect = 0.010, Method: Composition-based stats. Identities = 52/268 (19%), Positives = 86/268 (32%), Gaps = 70/268 (26%) Query: 60 YMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASK 119 Y GQ AL +A+ ELL++K A ++G Sbjct: 232 YRGQTALHIAIERRCKHYVELLVEKGADV-------HAQARG------------------ 266 Query: 120 RLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLM---KGARIER 176 F+ ++G F P+ LAA + ++VH L K A I R Sbjct: 267 --------------RFFQPKDEGGYFYFGELPLSLAACTNQPDIVHYLTENAHKKADIRR 312 Query: 177 PHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSE------------DPVL 224 D D+ + + L + L + P++ Sbjct: 313 -QDSRGNTVLHALVAIADNTRENTKFVTKVYDLLVIKCVKLYPDSSLEAIFNNDSMSPLM 371 Query: 225 TALELSNELAKLANIEK-EFK-NDYRKLSMQCKDFVVG----------VLDLCRDSEEVE 272 A +L ++ +I + E K + R LS + +D+ G +LD C + V Sbjct: 372 MAAKL-GKIGIFQHIIRLEIKDEEARHLSRKFRDWAYGPVYSSLYDLSMLDTCGEEVSVL 430 Query: 273 AIL--NGDLESAEPLEVHRHKASLSRVK 298 IL N +E+ + L R K Sbjct: 431 EILVYNSKVENRHEMLAVEPINELLRDK 458 >5IRX-A nrPDB Length = 636 Score = 67.9 bits (164), Expect = 2e-11, Method: Composition-based stats. Identities = 40/211 (18%), Positives = 89/211 (42%), Gaps = 14/211 (6%) Query: 469 IAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEG 528 ++ F +Q ++ + SE+ + + + + + ++ Sbjct: 377 VSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASM 436 Query: 529 LYAIAVVLSFSRIAYILPANESFGPLQISLGRT-VKDIFKFMVLFIMVFFAFMIGMFILY 587 ++++A+ ++ + Y + G + + + ++D+ +FM ++++ F F + L Sbjct: 437 VFSLAM--GWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLI 494 Query: 588 SYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMV 647 K N+ ++T E FK F G E T YD K + +L Y + Sbjct: 495 ED---GKYNSLYSTCLELFK--FTIGMGDLEFTE---NYDFKA---VFIILLLAYVILTY 543 Query: 648 VVLLNMLIAMINSSYQEIEDDSDVEWKFARS 678 ++LLNMLIA++ + +I +S WK R+ Sbjct: 544 ILLLNMLIALMGETVNKIAQESKNIWKLQRA 574 Score = 40.6 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 89/605 (14%), Positives = 176/605 (29%), Gaps = 170/605 (28%) Query: 38 GNIPVVRKMLEESKTLN-----VNC--VD--YMGQNALQLAVGNEHLEVTELLLKKENLA 88 G + +L+ ++ + VN D Y GQ AL +A+ ++ + LL++ Sbjct: 63 GQNDTIALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENGADV 122 Query: 89 RIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPD 148 + + DF+ + F Sbjct: 123 QAA---------------------------------------ANGDFFKKTKGRPGFYFG 143 Query: 149 ITPIILAAHCQKYEVVHMLLMKG---ARIERPHDYFCKCG----DCMEKQRHDSFSHSRS 201 P+ LAA + +V LL A I D + D+ S Sbjct: 144 ELPLSLAACTNQLAIVKFLLQNSWQPADI-SARDSVGNTVLHALVEVADNTVDNTKFVTS 202 Query: 202 RINAYKGLASPAYLSLSSEDPV-------LTALELSNELAKLANI-EKEFKN-DYRKLSM 252 N L + + +L E+ L S ++ LA I ++E + R LS Sbjct: 203 MYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSR 262 Query: 253 QCKDFVVG----------VLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIK 302 + ++ G +D C + +E I E+ ++ + L+R+ Sbjct: 263 KFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEP-LNRL----- 316 Query: 303 YEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWI----- 357 + + I+Y N + L + + F A Y+ Sbjct: 317 -------LQDKWDRFVKRIFYFNF-----------FVYCLYMII---FTAAAYYRPVEGL 355 Query: 358 ---APCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQI 414 + +G R + F G+ F ++ Sbjct: 356 PPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYF-------------------LQRRP 396 Query: 415 FRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQ--------LWNVLDFG--- 463 +++E+L V L M+ S L+ +EY+ N+L + Sbjct: 397 SLKSLFVDSYSEILFFVQSLFMLVSVV--LYFSQRKEYVASMVFSLAMGWTNMLYYTRGF 454 Query: 464 --------------------MLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTL 503 + +++ A + + +Y Y +L + T+ Sbjct: 455 QQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGKYNSLYSTCLELFKFTI 514 Query: 504 PPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVK 563 FT D + + L V+L++ + +L A G + + K Sbjct: 515 GMGDLEFT------ENYDFKAVFIILLLAYVILTYILLLNMLIA--LMGETVNKIAQESK 566 Query: 564 DIFKF 568 +I+K Sbjct: 567 NIWKL 571 >6C8G-A nrPDB Length = 675 Score = 67.5 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 34/163 (20%), Positives = 66/163 (40%), Gaps = 12/163 (7%) Query: 526 SEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVLFIMVFFAFMIGMF 584 + A+VL + Y + G I L + + KD+F+F++++++ + + Sbjct: 439 YLAVMVFALVLGWMNALYFTRGLKLTGTYSIMLQKILFKDLFRFLLVYLLFMIGYASALV 498 Query: 585 ILY---SYYLGAKVNAAFTTVEE---SFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYV- 637 L + ++ TV E + +S F L + D + I + Y Sbjct: 499 SLLNPCTSQESCIETSSQCTVPEYPSCRDSSTFSKFLLDLFKLTIGMGDLEMINSAKYPA 558 Query: 638 ----LYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFA 676 L Y + V+LLNMLIA++ + ++ +S WK Sbjct: 559 VFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKQIWKLQ 601 Score = 37.9 bits (86), Expect = 0.017, Method: Composition-based stats. Identities = 52/268 (19%), Positives = 86/268 (32%), Gaps = 70/268 (26%) Query: 60 YMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASK 119 Y GQ AL +A+ ELL++K A ++G Sbjct: 101 YRGQTALHIAIERRCKHYVELLVEKGADV-------HAQARG------------------ 135 Query: 120 RLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLM---KGARIER 176 F+ ++G F P+ LAA + ++VH L K A I R Sbjct: 136 --------------RFFQPKDEGGYFYFGELPLSLAACTNQPDIVHYLTENAHKKADIRR 181 Query: 177 PHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSE------------DPVL 224 D D+ + + L + L + P++ Sbjct: 182 -QDSRGNTVLHALVAIADNTRENTKFVTKVYDLLVIKCVKLYPDSSLEAIFNNDSMSPLM 240 Query: 225 TALELSNELAKLANIEK-EFK-NDYRKLSMQCKDFVVG----------VLDLCRDSEEVE 272 A +L ++ +I + E K + R LS + +D+ G +LD C + V Sbjct: 241 MAAKL-GKIGIFQHIIRLEIKDEEARHLSRKFRDWAYGPVYSSLYDLSMLDTCGEEVSVL 299 Query: 273 AIL--NGDLESAEPLEVHRHKASLSRVK 298 IL N +E+ + L R K Sbjct: 300 EILVYNSKVENRHEMLAVEPINELLRDK 327 >6BOA-A nrPDB Length = 742 Score = 66.8 bits (161), Expect = 4e-11, Method: Composition-based stats. Identities = 25/149 (16%), Positives = 61/149 (40%), Gaps = 8/149 (5%) Query: 530 YAIAVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVLFIMVFFAFMIGMFILYS 588 + A+VL + + Y + GP I + + + D+ +F L +V F +I++ Sbjct: 454 MSFALVLGWCNVMYFAEGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQ 513 Query: 589 YYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKF-IENIGYVLYGIYNVTMV 647 ++ + F T +T + ++ + + + Y + + Sbjct: 514 TEDPEELGHFYDYPMALFSTF------ELFLTIIDGPANYNVDLPFMYSITYAAFAIIAT 567 Query: 648 VVLLNMLIAMINSSYQEIEDDSDVEWKFA 676 +++LN+LIAM+ ++ + + D W+ Sbjct: 568 LLMLNLLIAMMGDTHWRVAHERDELWRAQ 596 Score = 51.4 bits (121), Expect = 2e-06, Method: Composition-based stats. Identities = 34/168 (20%), Positives = 64/168 (38%), Gaps = 24/168 (14%) Query: 28 EERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLK---- 83 E L AA+ ++ + K+L+ + V+ MG+ AL +A ++LE +L++ Sbjct: 46 ESPLLLAAKDNDVQALNKLLKY-EDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPE 104 Query: 84 -----KENLARIGD-ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYA 137 + G AL +A+ + +V A+L +++ + F Sbjct: 105 LVFEPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGE 164 Query: 138 YDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCG 185 + P+ AA E+V +L+ GA I R D Sbjct: 165 H------------PLSFAACVNSEEIVRLLIEHGADI-RAQDSLGNTV 199 Score = 39.8 bits (91), Expect = 0.005, Method: Composition-based stats. Identities = 27/170 (15%), Positives = 53/170 (31%), Gaps = 20/170 (11%) Query: 12 GPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVD-----------Y 60 P +F + L + A N+ +VR +L +++ Y Sbjct: 102 APELVFEPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIY 161 Query: 61 MGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKR 120 G++ L A E+ LL++ R D+L ++ ++ P + + Sbjct: 162 FGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNT-------VLHILILQPNKTFACQ 214 Query: 121 LTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMK 170 + + D D +TP LA + L+ K Sbjct: 215 MYNLLLSYDRHGDHLQPLDLVPNH--QGLTPFKLAGVEGNTVMFQHLMQK 262 >6E2G-A nrPDB Length = 727 Score = 66.4 bits (160), Expect = 5e-11, Method: Composition-based stats. Identities = 32/152 (21%), Positives = 61/152 (40%), Gaps = 14/152 (9%) Query: 530 YAIAVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVLFIMVFFAFMIGMFILY- 587 + A+VL + + Y + GP I + + + D+ +F L +V F +I++ Sbjct: 453 MSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQ 512 Query: 588 ---SYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNV 644 LG + S LF +I D F+ +I Y + I Sbjct: 513 TEDPDELGHFYDYPMALF--STFELFLTIIDG----PANYDVDLPFMYSITYAAFAI--- 563 Query: 645 TMVVVLLNMLIAMINSSYQEIEDDSDVEWKFA 676 +++LN+LIAM+ ++ + + D W+ Sbjct: 564 IATLLMLNLLIAMMGDTHWRVAHERDELWRAQ 595 Score = 56.7 bits (135), Expect = 4e-08, Method: Composition-based stats. Identities = 61/290 (21%), Positives = 105/290 (36%), Gaps = 35/290 (12%) Query: 28 EERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLK---- 83 E L AA+ N+ + K+L+ + V+ MG+ AL +A ++LE +L++ Sbjct: 46 ESPLLLAAKENNVQALIKLLKF-EGCEVHQKGAMGETALHIAALYDNLEAAMVLMEAAPE 104 Query: 84 -----KENLARIGD-ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYA 137 + G AL +A+ V +V A+L + S R T S + +Y Sbjct: 105 LVFEPMTSELYEGQTALHIAVINQNVNLVRALLARGA-SVSARATGSVFHYRPHNLIYYG 163 Query: 138 YDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCG-DCMEKQRHDSF 196 P+ AA E+V +L+ GA I R D + Q + +F Sbjct: 164 EH-----------PLSFAACVGSEEIVRLLIEHGADI-RAQDSLGNTVLHILILQPNKTF 211 Query: 197 S-HSRSRINAYKGLASPAYLSLSSEDPVLTALELSN------ELAKLANIEKEFKNDYRK 249 + + + +Y G L L + LT +L+ L K + Y Sbjct: 212 ACQMYNLLLSYDGGDHLKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQKRKHIQWTYGP 271 Query: 250 LSMQCKDFVVGVLDLCRDSEE-VEAILNGDLESAEPLEVHRHKASLSRVK 298 L+ D +D D + +E I+ A + L +K Sbjct: 272 LTSTLYDLTE--IDSSGDDQSLLELIVTTKKREARQILDQTPVKELVSLK 319 Score = 37.9 bits (86), Expect = 0.017, Method: Composition-based stats. Identities = 26/170 (15%), Positives = 55/170 (32%), Gaps = 21/170 (12%) Query: 12 GPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVD-----------Y 60 P +F + L + A N+ +VR +L +++ Y Sbjct: 102 APELVFEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIY 161 Query: 61 MGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKR 120 G++ L A E+ LL++ R D+L ++ ++ P + + Sbjct: 162 YGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNT-------VLHILILQPNKTFACQ 214 Query: 121 LTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMK 170 + + D + + + +TP LA + L+ K Sbjct: 215 MYNLLLSYDGGD---HLKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQK 261 >6DMR-A nrPDB Length = 730 Score = 63.7 bits (153), Expect = 3e-10, Method: Composition-based stats. Identities = 28/147 (19%), Positives = 57/147 (38%), Gaps = 10/147 (6%) Query: 533 AVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVLFIMVFFAFMIGMFILYSYYL 591 A+VL + + Y + GP I + + + D+ +F L +V F I + Sbjct: 457 ALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTED 516 Query: 592 GAKVNA--AFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVV 649 + + T S LF +I SV + + + Y + + ++ Sbjct: 517 PNNLGEFSDYPTALFSTFELFLTIIDGPANYSVD-------LPFMYCITYAAFAIIATLL 569 Query: 650 LLNMLIAMINSSYQEIEDDSDVEWKFA 676 +LN+ IAM+ ++ + + D W+ Sbjct: 570 MLNLFIAMMGDTHWRVAQERDELWRAQ 596 Score = 52.1 bits (123), Expect = 1e-06, Method: Composition-based stats. Identities = 59/325 (18%), Positives = 115/325 (35%), Gaps = 54/325 (16%) Query: 17 FNDRGTSLTAEEER---FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNE 73 + DR L E R L AA+ N + K+L +++ + +G+ AL +A + Sbjct: 32 YRDRVNMLQQERIRDSPLLQAAKE-NDLRLLKILLLNQSCDFQQRGAVGETALHVAALYD 90 Query: 74 HLEVTELLLKKENLA---------RIGD-ALLLAISKGYVRIVEAILNHPGFAASKRLTL 123 +LE LL++ +G AL +A+ + +V A+L + S R T Sbjct: 91 NLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGA-SVSARATG 149 Query: 124 SPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCK 183 + + + +Y P+ AA E+V +L+ GA I R D Sbjct: 150 AAFRRSPHNLIYYGEH-----------PLSFAACVGSEEIVRLLIEHGADI-RAQDSLGN 197 Query: 184 CG-DCMEKQRHDSFS-HSRSRINAYKGLAS-PAYLSLSSEDPVLTALELSNELAKLANIE 240 + Q + +F+ + + +Y + L L LT +L+ + + Sbjct: 198 TVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAG-VEGNTVMF 256 Query: 241 KEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLA 300 + + + C + DL E+ LS ++L Sbjct: 257 QHLMQKRKHVQWTCGPLTSTLYDLT--------------------EIDSWGEELSFLELV 296 Query: 301 I---KYEVKKFVAHPNCQQQLLTIW 322 + K E ++ + ++ + W Sbjct: 297 VSSKKREARQILEQTPVKELVSFKW 321 >2KXP-C nrPDB Length = 118 Score = 63.3 bits (152), Expect = 4e-10, Method: Composition-based stats. Identities = 25/97 (25%), Positives = 43/97 (44%), Gaps = 7/97 (7%) Query: 28 EERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENL 87 ++ F+ A + G++ V+ + +K +VN G+ L A LE+ E LL K Sbjct: 3 DKEFMWALKNGDLDEVKDYV--AKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGAD 60 Query: 88 ARIGD-----ALLLAISKGYVRIVEAILNHPGFAASK 119 D LL A+ +G+V V+ +L+ K Sbjct: 61 INAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVK 97 Score = 42.5 bits (98), Expect = 8e-04, Method: Composition-based stats. Identities = 17/75 (22%), Positives = 29/75 (38%), Gaps = 2/75 (2%) Query: 19 DRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVT 78 D +L + AA+ G + ++ +L K ++N D L AV H+ Sbjct: 27 DVNRTLEGGRKPLHYAADCGQLEILEFLLL--KGADINAPDKHHITPLLSAVYEGHVSCV 84 Query: 79 ELLLKKENLARIGDA 93 +LLL K + Sbjct: 85 KLLLSKGADKTVKGP 99 Score = 40.2 bits (92), Expect = 0.004, Method: Composition-based stats. Identities = 23/110 (20%), Positives = 35/110 (31%), Gaps = 30/110 (27%) Query: 69 AVGNEHLEVTELLLKKENLARIG-----DALLLAISKGYVRIVEAILNHPGFAASKRLTL 123 A+ N L+ + + K L A G + I+E +L Sbjct: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGA--------- 59 Query: 124 SPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGAR 173 D A D+ ITP++ A + V +LL KGA Sbjct: 60 ----------DINAPDK------HHITPLLSAVYEGHVSCVKLLLSKGAD 93 Score = 35.9 bits (81), Expect = 0.072, Method: Composition-based stats. Identities = 12/27 (44%), Positives = 17/27 (62%) Query: 151 PIILAAHCQKYEVVHMLLMKGARIERP 177 P+ AA C + E++ LL+KGA I P Sbjct: 38 PLHYAADCGQLEILEFLLLKGADINAP 64 >4NIK-A nrPDB Length = 230 Score = 60.6 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 45/224 (20%), Positives = 76/224 (33%), Gaps = 40/224 (17%) Query: 33 DAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD 92 + A G + +++ + K+L D + AL A H E+ E LL+ D Sbjct: 16 NLAYSGKLEELKESILADKSLATR-TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKD 74 Query: 93 -----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSP 147 L +A S G IV+A+L A +++G Sbjct: 75 DAGWSPLHIAASAGRDEIVKALLGKGA-------------------QVNAVNQNG----- 110 Query: 148 DITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYK 207 TP+ AA ++E+ MLL GA + Y + + H A Sbjct: 111 -CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAST 169 Query: 208 GLAS-----PAYLSLSSEDPVLTALELSNELAKLANIEKEFKND 246 + P +L+ E E +++ A+I E K + Sbjct: 170 NIQDTEGNTPLHLACDEER----VEEAKLLVSQGASIYIENKEE 209 >3ZKJ-A nrPDB Length = 261 Score = 60.2 bits (144), Expect = 4e-09, Method: Composition-based stats. Identities = 33/156 (21%), Positives = 57/156 (36%), Gaps = 14/156 (8%) Query: 33 DAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLAR--I 90 +AA +G+ +R ++ + +N+ D++ + L A HL ++LLK Sbjct: 9 EAAIHGHQLSLRNLISQGWAVNIITADHV--SPLHEACLGGHLSCVKILLKHGAQVNGVT 66 Query: 91 GD---ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDE------- 140 D L A G V +L H + SP + + + Sbjct: 67 ADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGN 126 Query: 141 DGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIER 176 + S TP+ LA Q+ V LL GA + + Sbjct: 127 IDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ 162 Score = 41.7 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 20/121 (16%), Positives = 36/121 (29%), Gaps = 30/121 (24%) Query: 64 NALQLAVGNEHLEVTELLLKKENLARI-----GDALLLAISKGYVRIVEAILNHPGFAAS 118 + + A + H L+ + I L A G++ V+ +L H Sbjct: 5 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGA---- 60 Query: 119 KRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPH 178 D TP+ A ++ V++LL GA ++ Sbjct: 61 ---------------QVNGVTADWH------TPLFNACVSGSWDCVNLLLQHGASVQPES 99 Query: 179 D 179 D Sbjct: 100 D 100 >2DWZ-A nrPDB Length = 231 Score = 59.4 bits (142), Expect = 7e-09, Method: Composition-based stats. Identities = 45/224 (20%), Positives = 75/224 (33%), Gaps = 40/224 (17%) Query: 33 DAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD 92 + A G + +++ + K+L D + AL A H E+ E LL+ D Sbjct: 12 NLAYSGKLDELKERILADKSLATR-TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKD 70 Query: 93 -----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSP 147 L +A S G IV+A+L A +++G Sbjct: 71 DAGWSPLHIAASAGRDEIVKALLVKGA-------------------HVNAVNQNG----- 106 Query: 148 DITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYK 207 TP+ AA ++E+ MLL GA + Y + + H A Sbjct: 107 -CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYDATAMHRAAAKGNLKMVHILLFYKAST 165 Query: 208 GLAS-----PAYLSLSSEDPVLTALELSNELAKLANIEKEFKND 246 + P +L+ E E + + A+I E K + Sbjct: 166 NIQDTEGNTPLHLACDEER----VEEAKFLVTQGASIYIENKEE 205 >3TU9-A nrPDB Length = 363 Score = 59.1 bits (141), Expect = 7e-09, Method: Composition-based stats. Identities = 16/57 (28%), Positives = 27/57 (47%), Gaps = 5/57 (8%) Query: 207 KGLASPAYLSLSSEDPVLTALELSNELAK-LANIEKEFKND----YRKLSMQCKDFV 258 K L+ A+ ++ +L A E + +AK L +I E + YR+L + D V Sbjct: 13 KELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRV 69 >2RFA-A nrPDB Length = 232 Score = 57.9 bits (138), Expect = 2e-08, Method: Composition-based stats. Identities = 48/216 (22%), Positives = 85/216 (39%), Gaps = 26/216 (12%) Query: 28 EERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLK---- 83 E L AA+ ++ + K+L+ + V+ MG+ AL +A ++LE +L++ Sbjct: 4 ESPLLLAAKENDVQALSKLLKF-EGCEVHQRGAMGETALHIAALYDNLEAAMVLMEAAPE 62 Query: 84 -----KENLARIGD-ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYA 137 + G AL +A+ V +V A+L + S R T S + +Y Sbjct: 63 LVFEPMTSELYEGQTALHIAVINQNVNLVRALLARGA-SVSARATGSVFHYRPHNLIYYG 121 Query: 138 YDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCG-DCMEKQRHDSF 196 P+ AA E+V +L+ GA I R D + Q + +F Sbjct: 122 EH-----------PLSFAACVGSEEIVRLLIEHGADI-RAQDSLGNTVLHILILQPNKTF 169 Query: 197 S-HSRSRINAYKGLASPAYLSLSSEDPVLTALELSN 231 + + + +Y G L L + LT +L+ Sbjct: 170 ACQMYNLLLSYDGGDHLKSLELVPNNQGLTPFKLAG 205 Score = 38.6 bits (88), Expect = 0.010, Method: Composition-based stats. Identities = 26/170 (15%), Positives = 55/170 (32%), Gaps = 21/170 (12%) Query: 12 GPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVD-----------Y 60 P +F + L + A N+ +VR +L +++ Y Sbjct: 60 APELVFEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIY 119 Query: 61 MGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKR 120 G++ L A E+ LL++ R D+L ++ ++ P + + Sbjct: 120 YGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNT-------VLHILILQPNKTFACQ 172 Query: 121 LTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMK 170 + + D + + + +TP LA + L+ K Sbjct: 173 MYNLLLSYDGGD---HLKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQK 219 >1G3N-B nrPDB Length = 168 Score = 55.6 bits (132), Expect = 8e-08, Method: Composition-based stats. Identities = 23/94 (24%), Positives = 40/94 (42%), Gaps = 7/94 (7%) Query: 32 LDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIG 91 L + GN + R++L + N + D G + A L+ + LL+ + I Sbjct: 42 LQVMKLGNPEIARRLLL--RGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIE 99 Query: 92 D-----ALLLAISKGYVRIVEAILNHPGFAASKR 120 D L LA +G++R+VE ++ H R Sbjct: 100 DNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHR 133 Score = 51.7 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 33/118 (27%), Positives = 44/118 (37%), Gaps = 13/118 (11%) Query: 3 EKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMG 62 E RR +RG DR DAA G + ++ +LE +VN D G Sbjct: 51 EIARRLLLRGANPDLKDRTGFAVIH-----DAARAGFLDTLQTLLEF--QADVNIEDNEG 103 Query: 63 QNALQLAVGNEHLEVTELLLKK-----ENLARIGD-ALLLAISKGYVRIVEAILNHPG 114 L LA HL V E L+K + GD A LA G +V + + Sbjct: 104 NLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161 Score = 45.2 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 27/149 (18%), Positives = 51/149 (34%), Gaps = 33/149 (22%) Query: 30 RFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLAR 89 AA G++ + +L+ + +N + G+ ALQ+ + + E+ LL + Sbjct: 8 ELASAAARGDLEQLTSLLQNNVNVN--AQNGFGRTALQV-MKLGNPEIARRLLLRGANPD 64 Query: 90 IGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTR 144 + D + A G++ ++ +L D D +G Sbjct: 65 LKDRTGFAVIHDAARAGFLDTLQTLLEFQA-------------------DVNIEDNEGNL 105 Query: 145 FSPDITPIILAAHCQKYEVVHMLLMKGAR 173 P+ LAA VV L+ A Sbjct: 106 ------PLHLAAKEGHLRVVEFLVKHTAS 128 >5ET1-A nrPDB Length = 353 Score = 55.2 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 47/212 (22%), Positives = 81/212 (38%), Gaps = 22/212 (10%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLK-KENL--ARI 90 AA G++P ++ ++ VN G L LA HLEVT+ L++ R Sbjct: 146 AAAKGDLPSLKLLVGHYPE-GVNAQTNNGATPLYLACQEGHLEVTKYLVQECSADPHLRA 204 Query: 91 GD---ALLLAISKGYVRIVEAILNHPGFAASKR-----LTLSPCEQELQDDDFYAYDEDG 142 D L A G+ ++ +++ + S++ + G Sbjct: 205 QDGMTPLHAAAQMGHNPVLVWLVSFADVSFSEQDHDGATAMHFAASRGHTKVLSWLLLHG 264 Query: 143 TRFSPDI---TPIILAAHCQKYEVVHMLLMKGARIE-RPHDYFCKCGDCMEKQRHDSFSH 198 S D+ TP+ AA + E +L + GA ++ R HD + D E H +H Sbjct: 265 AEISQDLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGY-TAADLAEFNGH---TH 320 Query: 199 SRSRINAYKGLASPAYLSLSSEDPV-LTALEL 229 + + L S + LS + + L A +L Sbjct: 321 CSRYLRTVQTL-SLEHRVLSRDQSMDLEAKQL 351 Score = 49.0 bits (115), Expect = 8e-06, Method: Composition-based stats. Identities = 32/165 (19%), Positives = 53/165 (32%), Gaps = 29/165 (17%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKK-----ENLA 88 AA +G+ VV+ +L + N G + A L +LL+ Sbjct: 112 AARFGHPDVVKWLLYQG-GANSAITTDTGALPIHYAAAKGDLPSLKLLVGHYPEGVNAQT 170 Query: 89 RIG-DALLLAISKGYVRIVEAILNH----------------PGFAASKRLTLSPCEQELQ 131 G L LA +G++ + + ++ A + Sbjct: 171 NNGATPLYLACQEGHLEVTKYLVQECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFA 230 Query: 132 DDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIER 176 D F D DG T + AA +V+ LL+ GA I + Sbjct: 231 DVSFSEQDHDGA------TAMHFAASRGHTKVLSWLLLHGAEISQ 269 >4O1O-A nrPDB Length = 717 Score = 54.8 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 42/188 (22%), Positives = 73/188 (38%), Gaps = 42/188 (22%) Query: 30 RFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGN----EHLEVTELLLKKE 85 +DAAE G++ VV +L + V+ D MG+NAL A+ N + +T LLL Sbjct: 154 ALMDAAEKGHVGVVTILL-HAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHG 212 Query: 86 NLARI-----GDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDE 140 + L+LA+ + + +V+ +L E + + D Sbjct: 213 ADVNVRGEGSKTPLILAVERKNLDLVQMLL------------------EQEQIEVNDTDR 254 Query: 141 DGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSR 200 +G T ++LA + E+ +L +GA CGD + R + S Sbjct: 255 EGK------TALLLAVELRLEEIAKLLCHRGAST--------NCGDLVAIARRNYDSDLV 300 Query: 201 SRINAYKG 208 + +K Sbjct: 301 KFLRLHKA 308 Score = 48.3 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 32/152 (21%), Positives = 54/152 (35%), Gaps = 31/152 (20%) Query: 28 EERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENL 87 EE A + +I VR++LE N + G + L AV + ++ LLLK Sbjct: 9 EEMLTQAVQEADIEQVRQLLERGADANFQ-EEEWGWSPLHSAVQMDSEDLVALLLKHGAD 67 Query: 88 A-----RIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDG 142 ++A G VR+++ +L + +D D +G Sbjct: 68 PCLRKRNGATPFIIAGITGNVRLLQLLLPN-------------------VEDVNECDVNG 108 Query: 143 TRFSPDITPIILAAHCQKYEVVHMLLMKGARI 174 T + AA + E + L GA + Sbjct: 109 ------FTAFMEAAVYGRVEALRFLYENGADV 134 Score = 46.0 bits (107), Expect = 6e-05, Method: Composition-based stats. Identities = 39/167 (23%), Positives = 60/167 (35%), Gaps = 29/167 (17%) Query: 30 RFLDAAEYGNIPVVRKMLEESKTLNVNC----------VDYMGQNALQLAVGNEHLEVTE 79 F++AA YG + +R + E +VN + G AL A H+ V Sbjct: 111 AFMEAAVYGRVEALRFLYE--NGADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVT 168 Query: 80 LLL-KKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAY 138 +LL + D + G +V A+LN P +K +T + D Sbjct: 169 ILLHAMKAEVDARDNM------GRNALVYALLN-PDDGKAKAITRLLLDHG---ADVNVR 218 Query: 139 DEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCG 185 E TP+ILA + ++V MLL + D K Sbjct: 219 GEGSK------TPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTA 259 Score = 46.0 bits (107), Expect = 8e-05, Method: Composition-based stats. Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 5/100 (5%) Query: 19 DRGTSLTA----EEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEH 74 D G + + + A E N+ +V+ +LE+ + + VN D G+ AL LAV Sbjct: 210 DHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQ-EQIEVNDTDREGKTALLLAVELRL 268 Query: 75 LEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPG 114 E+ +LL + GD + +A +V+ + H Sbjct: 269 EEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHKA 308 Score = 39.8 bits (91), Expect = 0.006, Method: Composition-based stats. Identities = 26/125 (20%), Positives = 46/125 (36%), Gaps = 9/125 (7%) Query: 30 RFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKEN-LA 88 L+ + + R +L+ +VN + L LAV ++L++ ++LL++E Sbjct: 192 ALLNPDDGKAKAITRLLLD--HGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEV 249 Query: 89 RIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQD-DDFYAYDEDG 142 D ALLLA+ I + + + L D F + G Sbjct: 250 NDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHKAG 309 Query: 143 TRFSP 147 F P Sbjct: 310 EDFRP 314 >6AUN-A nrPDB Length = 752 Score = 52.5 bits (124), Expect = 8e-07, Method: Composition-based stats. Identities = 42/239 (17%), Positives = 84/239 (35%), Gaps = 16/239 (6%) Query: 35 AEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARI---- 90 A G+ V ++L ++ + +N V+ G L LA E+ +LL + Sbjct: 193 AVQGDNSQVLQLLGKNASAGLNQVNKQGLTPLHLACQMGKQEMVRVLLLCNARCNVMGPS 252 Query: 91 GDALLLAISKGYVRIVEAILNHPGF---AASKRLTLSPCEQELQDDDFYAYDEDG----T 143 G + A+ E I++ + R SP + + G + Sbjct: 253 GFPIHTAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCDVDS 312 Query: 144 RFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRI 203 + T + +A +++ V +LL GA P ++ + + ++ I Sbjct: 313 TSAAGNTALHVAVMRNRFDCVMVLLTYGANAGTPGEHGNTPLHLAISKDN--MEMIKALI 370 Query: 204 NAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVL 262 + +P E P A ++S +L L I + K + SM+ + + L Sbjct: 371 VFGAEVDTPNDF---GETPAFMASKISKQLQDLMPISRARKPAFILSSMRDEKRIHDHL 426 Score = 37.1 bits (84), Expect = 0.029, Method: Composition-based stats. Identities = 23/129 (17%), Positives = 43/129 (33%), Gaps = 34/129 (26%) Query: 55 VNCVDYM----GQNALQLAVGNEHLEV-TELLLKKENLARIGD-----ALLLAISKGYVR 104 ++C + G L LA E+ EL+ + D A A+ + Sbjct: 141 ISCANSTENEEGCTPLHLACRKGDSEILVELVQYCHAQMDVTDNKGETAFHYAVQGDNSQ 200 Query: 105 IVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVV 164 +++ + + ++ G +TP+ LA K E+V Sbjct: 201 VLQLLGKNASAG------------------LNQVNKQG------LTPLHLACQMGKQEMV 236 Query: 165 HMLLMKGAR 173 +LL+ AR Sbjct: 237 RVLLLCNAR 245 >3EHQ-A nrPDB Length = 222 Score = 52.1 bits (123), Expect = 9e-07, Method: Composition-based stats. Identities = 27/95 (28%), Positives = 46/95 (48%), Gaps = 8/95 (8%) Query: 33 DAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELL-----LKKENL 87 +AA+ GN+ +R+ L+ + VN +D G AL A H ++ E+L ++ Sbjct: 79 EAAKRGNLSWLRECLD--NRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQ 136 Query: 88 ARIGD-ALLLAISKGYVRIVEAILNHPGFAASKRL 121 ++GD AL A KGY IV+ +L + + Sbjct: 137 NKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNI 171 >1XFB-A nrPDB Length = 365 Score = 51.4 bits (121), Expect = 2e-06, Method: Composition-based stats. Identities = 15/58 (25%), Positives = 24/58 (41%), Gaps = 5/58 (8%) Query: 207 KGLASPAYLSLSSEDPVLTALELSNELAK-LANIEKEFKND----YRKLSMQCKDFVV 259 K L+ A ++ +L A E +AK L+ I E + YR++ D V Sbjct: 14 KELSDIALRIVAPGKGILAADESVGSMAKRLSQIGVENTEENRRLYRQVLFSADDRVK 71 >1WG0-A nrPDB Length = 243 Score = 50.6 bits (119), Expect = 3e-06, Method: Composition-based stats. Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 5/92 (5%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD- 92 A GN+ VV+ + + ++N + G L LAVG + EV++ L++ RI D Sbjct: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 Query: 93 ----ALLLAISKGYVRIVEAILNHPGFAASKR 120 L A S G ++++E + A + + Sbjct: 139 FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQ 170 Score = 42.5 bits (98), Expect = 8e-04, Method: Composition-based stats. Identities = 26/142 (18%), Positives = 47/142 (33%), Gaps = 18/142 (12%) Query: 59 DYMGQNALQLAVGNEHLEVTELLLKKENLARIGD--------ALLLAISKGYVRIVEAI- 109 D G+ L +V + E+T LL K + D +A S G + +V+++ Sbjct: 33 DQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLY 92 Query: 110 -------LNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDIT--PIILAAHCQK 160 LN L L+ ++ + F + R P+ AA Sbjct: 93 DRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGS 152 Query: 161 YEVVHMLLMKGARIERPHDYFC 182 +++ +L G D Sbjct: 153 LKLIELLCGLGKSAVNWQDKQG 174 >1BLX-B nrPDB Length = 166 Score = 49.4 bits (116), Expect = 6e-06, Method: Composition-based stats. Identities = 21/116 (18%), Positives = 42/116 (36%), Gaps = 7/116 (6%) Query: 29 ERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLA 88 + L +G+ V ++L++ + N D G + + A L+ ++L++ Sbjct: 43 KTALQVMMFGSPAVALELLKQ--GASPNVQDASGTSPVHDAARTGFLDTLKVLVEHGADV 100 Query: 89 RIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYD 139 D + LAI +G+ +V + L+P E Q D Sbjct: 101 NALDSTGSLPIHLAIREGHSSVVSFLAPESDLHHRDASGLTPLELARQRGAQNLMD 156 Score = 48.7 bits (114), Expect = 1e-05, Method: Composition-based stats. Identities = 20/84 (23%), Positives = 34/84 (40%), Gaps = 6/84 (7%) Query: 33 DAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLK----KENLA 88 DAA G + ++ ++E +VN +D G + LA+ H V L A Sbjct: 80 DAARTGFLDTLKVLVE--HGADVNALDSTGSLPIHLAIREGHSSVVSFLAPESDLHHRDA 137 Query: 89 RIGDALLLAISKGYVRIVEAILNH 112 L LA +G +++ + H Sbjct: 138 SGLTPLELARQRGAQNLMDILQGH 161 Score = 36.3 bits (82), Expect = 0.050, Method: Composition-based stats. Identities = 19/96 (19%), Positives = 38/96 (39%), Gaps = 8/96 (8%) Query: 87 LARIGDALLLAISKGYVRIVEAILNHP--GFAASKRLTLSPCEQELQDDDFYAYDEDGTR 144 +GD L A ++G V+ V +L+ A R + + + A + Sbjct: 5 EVCVGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSPAVALELLKQG 64 Query: 145 FSPDI------TPIILAAHCQKYEVVHMLLMKGARI 174 SP++ +P+ AA + + +L+ GA + Sbjct: 65 ASPNVQDASGTSPVHDAARTGFLDTLKVLVEHGADV 100 >4OT9-A nrPDB Length = 359 Score = 49.0 bits (115), Expect = 9e-06, Method: Composition-based stats. Identities = 28/138 (20%), Positives = 48/138 (34%), Gaps = 27/138 (19%) Query: 55 VNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD-----ALLLAIS--KGYVRIVE 107 VN +++ Q L LAV V LL+ + D A+ LA+ G ++ Sbjct: 114 VNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLR 173 Query: 108 AILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHML 167 A+L A + L + E + P+ LA + E + +L Sbjct: 174 ALLQSGAPAVPQLLHMPDFEG--------------------LYPVHLAVRARSPECLDLL 213 Query: 168 LMKGARIERPHDYFCKCG 185 + GA +E + Sbjct: 214 VDSGAEVEATERQGGRTA 231 Score = 44.8 bits (104), Expect = 2e-04, Method: Composition-based stats. Identities = 30/168 (17%), Positives = 59/168 (35%), Gaps = 24/168 (14%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLA--VGNEHLEVTELLLKKEN----- 86 A G VV +L + +D G +A+ LA G E+ LL+ Sbjct: 128 AVITGQTSVVSFLLRV--GADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQ 185 Query: 87 LARIGD-----ALLLAISKGYVRIVEAILNHPGF--AASKRLTLSPCEQELQDDDFYAYD 139 L + D + LA+ ++ +++ A ++ + + ++ Sbjct: 186 LLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVT 245 Query: 140 EDGTRFSPDI--------TPIILAAHCQKYEVVHMLLMKGARIERPHD 179 T+ ++ TP+ LAA + +LL GA I ++ Sbjct: 246 HLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENE 293 >5DND-A nrPDB Length = 588 Score = 48.7 bits (114), Expect = 1e-05, Method: Composition-based stats. Identities = 27/150 (18%), Positives = 50/150 (33%), Gaps = 16/150 (10%) Query: 32 LDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIG 91 L A G + ++ ++E ++ D GQ L +A N V +LL + Sbjct: 427 LALAHAGELEALQALMEL--GSDLRLKDSNGQTLLHVAARNGRDGVVTMLLHRGMDVNAR 484 Query: 92 D-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCE--QELQDDDFYAYDEDGTR 144 D LLLA+ + + + + + L + E + D G Sbjct: 485 DRDGLSPLLLAVQGRHRECIRLLRKAGACLSPQDLKDAGTELCRLASRADMEGLQAWGQA 544 Query: 145 FSPDITP-------IILAAHCQKYEVVHML 167 + P + +A EV+ +L Sbjct: 545 GADLQQPGYDGRSALCVAEAAGNQEVLALL 574 >1BD8-A nrPDB Length = 156 Score = 47.5 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 20/116 (17%), Positives = 44/116 (37%), Gaps = 7/116 (6%) Query: 29 ERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLA 88 + L +G+ + ++L++ + N D G + + A L+ ++L++ Sbjct: 37 KTALQVMMFGSTAIALELLKQ--GASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADV 94 Query: 89 RIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYD 139 + D + LA+ +G+ +V + L+P E LQ D Sbjct: 95 NVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVD 150 Score = 38.6 bits (88), Expect = 0.012, Method: Composition-based stats. Identities = 21/97 (21%), Positives = 39/97 (40%), Gaps = 8/97 (8%) Query: 89 RIGDALLLAISKGYVRIVEAILNHP--GFAASKRLTLSPCEQELQDDDFYAYDEDGTRFS 146 R GD L A ++G V+ V +L+ A R + + + A + S Sbjct: 1 RAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGAS 60 Query: 147 PDI------TPIILAAHCQKYEVVHMLLMKGARIERP 177 P++ +P+ AA + + +L+ GA + P Sbjct: 61 PNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVP 97 >5HI9-A nrPDB Length = 770 Score = 47.5 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 46/256 (17%), Positives = 91/256 (35%), Gaps = 30/256 (11%) Query: 541 IAYILPANESFGPLQISLGRT-VKDIFKFMVLFIMVFFAFMIGMFILY--------SYYL 591 + Y + G + + + ++D+ +F++++++ F F + + L Sbjct: 512 LLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKAPEDN 571 Query: 592 GAKVNAAFTTVEESFKTLFWSIF--GLSEVTSVVLKYDHKFIENI-----GYVLYGIYNV 644 + V T +E + SI L + + F E + +L Y + Sbjct: 572 NSTVTEQPTVGQEEEPAPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVL 631 Query: 645 TMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSY-----------FDDGKTLPP 693 V+LLNMLIA+++ + + D+S WK ++ L +G+ L Sbjct: 632 LTYVLLLNMLIALMSETVNHVADNSWSIWKLQKAISVLEMENGYWWCRRKKHREGRLLKV 691 Query: 694 PFSLVPSPKSFVYFIMRIVNFPKCRR---RRLQKDIEMGMGNSKSRLNLFTQSNSRVFES 750 +P F + VN+ + + G+ +K NS E Sbjct: 692 GTRGDGTPDERWCFRVEEVNWAAWEKTLPTLSEDPSGPGITGNKKNPTSKPGKNSASEED 751 Query: 751 HSFNSILNQPTRYQQI 766 H +L PT Q+ Sbjct: 752 HLPLQVLQSPTETSQV 767 Score = 38.6 bits (88), Expect = 0.012, Method: Composition-based stats. Identities = 35/165 (21%), Positives = 54/165 (32%), Gaps = 47/165 (28%) Query: 53 LNVNCVD--YMGQNALQLAVGNEHLEVTELLLKKENLA-----------------RIGD- 92 +N C D Y G +AL +A+ L+ +LL++ G+ Sbjct: 153 VNAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGEL 212 Query: 93 ALLLAISKGYVRIVEAILNHPGFAASKRLT----------------LSPCEQELQDDDFY 136 L LA +V +L +P AS T SP L + Sbjct: 213 PLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYD 272 Query: 137 AYDEDGTRFSPDI-----------TPIILAAHCQKYEVVHMLLMK 170 + G R P + TP+ LAA K E+ +L + Sbjct: 273 GLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQR 317 >5D68-A nrPDB Length = 486 Score = 46.7 bits (109), Expect = 4e-05, Method: Composition-based stats. Identities = 32/149 (21%), Positives = 57/149 (38%), Gaps = 15/149 (10%) Query: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKEN------L 87 +A G+ ++ ++L S+ +VN +D + A +E T +LL+K Sbjct: 45 SACEGDSELLSRLL--SERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNLLN 102 Query: 88 ARIGDALLLAISKGYVRIVEAILNHPG-----FAASKRLTLSPCEQELQDDDFYAYDEDG 142 ++ L A G+ IV+ +LNHP R L+ CE+ Q++ A Sbjct: 103 GQLSSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNICEENKQNNWEEAAKLLK 162 Query: 143 TRFSPDITPIILAAHCQKYEVVHMLLMKG 171 + + + Y V L G Sbjct: 163 EAINKPYEKVRIYRMDGSYRSVE--LKHG 189 Score = 35.9 bits (81), Expect = 0.082, Method: Composition-based stats. Identities = 40/264 (15%), Positives = 83/264 (31%), Gaps = 45/264 (17%) Query: 65 ALQLAVGNEHLEVTELLLKKENLARIGD-----ALLLAISKGYVRIVEAILNHPGFAASK 119 L + E+ LL + D + A G V +L Sbjct: 41 PLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGK----- 95 Query: 120 RLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHD 179 C L + +P+ AA E+V +LL D Sbjct: 96 ------CNPNLLNGQLS-------------SPLHFAAGGGHAEIVQILLNHPETDRHITD 136 Query: 180 YFCK-----CGDCMEKQRHDSFSHSRSRIN-AYKGL----ASPAYLSLSSEDPVLTALEL 229 + C + + ++ + IN Y+ + +Y S+ + T ++ Sbjct: 137 QQGRSPLNICEENKQNNWEEAAKLLKEAINKPYEKVRIYRMDGSYRSVELKHGNNTTVQQ 196 Query: 230 SNELAKLANIEKEFKNDY---RKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLE 286 E +L+ +++ + LS+Q K + + + E + + N D + P Sbjct: 197 IMEGMRLSQETQQYFTIWICSENLSLQLKPYHKPLQHVRDWPEILAELTNLDPQRETPQL 256 Query: 287 VHRHKASLSRVKLAIKYEVKKFVA 310 R R+ L ++ +++ +A Sbjct: 257 FLRRD---VRLPLEVEKQIEDPLA 277 >3LJN-A nrPDB Length = 364 Score = 46.3 bits (108), Expect = 5e-05, Method: Composition-based stats. Identities = 29/159 (18%), Positives = 53/159 (33%), Gaps = 16/159 (10%) Query: 29 ERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKE--- 85 E+ AA G VR+++E ++ + G AL LA ++ + L Sbjct: 22 EKIHVAARKGQTDEVRRLIET--GVSPTIQNRFGCTALHLACKFGCVDTAKYLASVGEVH 79 Query: 86 NLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRF 145 +L + LA+ +V A++ E L + D +E G+ Sbjct: 80 SLWHGQKPIHLAVMANKTDLVVALVEGAKERGQ------MPESLLNECDEREVNEIGSHV 133 Query: 146 SP--DITPIILAAHCQ--KYEVVHMLLMKGARIERPHDY 180 T + E++ +L+ GA D Sbjct: 134 KHCKGQTALHWCVGLGPEYLEMIKILVQLGAS-PTAKDK 171 >1D9S-A nrPDB Length = 136 Score = 46.3 bits (108), Expect = 6e-05, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 37/95 (38%), Gaps = 9/95 (9%) Query: 26 AEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKE 85 + + AA G + VR++LE + N ++ G+ +Q+ + +V ELLL Sbjct: 11 SSDAGLATAAARGQVETVRQLLEA--GADPNALNRFGRRPIQVMMM-GSAQVAELLLLHG 67 Query: 86 NLARIGD------ALLLAISKGYVRIVEAILNHPG 114 D + A +G++ + + Sbjct: 68 AEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGA 102 >5EK0-A nrPDB Length = 296 Score = 44.4 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 34/235 (14%), Positives = 78/235 (33%), Gaps = 49/235 (20%) Query: 427 MLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQ 486 + +V+++ +++ + W++ DF ++ I Sbjct: 64 WINVVFIILFTIEIILRIYVHRI-SFFKDPWSLFDFVVVII------------------- 103 Query: 487 QYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILP 546 V ++ + + P + AR RI ++ Sbjct: 104 SIVGMFLADLIETYFVSPTLFRVIRLARIG-----------------------RILRLVT 140 Query: 547 ANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESF 606 A + +L + + + L + F+ F I L+ G + F T+ ESF Sbjct: 141 AVPQMRKIVSALISVIPGMLSVIALMTLFFYIFAIMATQLF----GERFPEWFGTLGESF 196 Query: 607 KTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSS 661 TLF + S +V + +V + + + V++N+++A+I + Sbjct: 197 YTLFQVMTLESWSMGIVRPLMEVYP--YAWVFFIPFIFVVTFVMINLVVAIIVDA 249 >2A5E-A nrPDB Length = 156 Score = 44.4 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 20/100 (20%), Positives = 36/100 (36%), Gaps = 9/100 (9%) Query: 21 GTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTEL 80 G+S+ + AA G + VR +LE N + G+ +Q+ + V EL Sbjct: 6 GSSMEPSADWLATAAARGRVEEVRALLEA--GALPNAPNSYGRRPIQVMMM-GSARVAEL 62 Query: 81 LLKKENLARIGD------ALLLAISKGYVRIVEAILNHPG 114 LL D + A +G++ + + Sbjct: 63 LLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGA 102 >3UI2-A nrPDB Length = 244 Score = 44.0 bits (102), Expect = 3e-04, Method: Composition-based stats. Identities = 31/176 (17%), Positives = 63/176 (35%), Gaps = 27/176 (15%) Query: 24 LTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLK 83 ++ E + AA + + ++LE+ +V+ VD G+ AL G + LL + Sbjct: 42 VSEYETPWWTAARKADEQALSQLLEDR---DVDAVDENGRTALLFVAGLGSDKCVRLLAE 98 Query: 84 KENLARIGD------ALLLAISKGYVRIVEAILNHPGFAA---SKRLTLSPCEQELQDDD 134 D AL +A +VEA++ + LT +E+ Sbjct: 99 AGADLDHRDMRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELAREIL--- 155 Query: 135 FYAYDEDGTRFSPDITPIILAAHCQKYEVVHML---LMKGARIERPHDYFCKCGDC 187 + +P P+ +V+++L + + A ++ + K D Sbjct: 156 ---------KTTPKGNPMQFGRRIGLEKVINVLEGQVFEYAEVDEIVEKRGKGKDV 202 >6N4I-A nrPDB Length = 288 Score = 44.0 bits (102), Expect = 3e-04, Method: Composition-based stats. Identities = 30/169 (17%), Positives = 65/169 (38%), Gaps = 16/169 (9%) Query: 499 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVV----------LSFSRIAYILPAN 548 E+ L + ++ +D W D I++ L + + R+ ++ A Sbjct: 75 IEIILRIYVHRISFFKDPWSLFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFRLVTAV 134 Query: 549 ESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKT 608 + +L + + + L + F+ F I L+ G + F T+ ESF T Sbjct: 135 PQMRKIVSALISVIPGMLSVIALMTLFFYIFAIMATQLF----GERFPEWFGTLGESFYT 190 Query: 609 LFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAM 657 LF + S +V + +V + + + V++N+++A+ Sbjct: 191 LFQVMTLESWSMGIVRPLMEVYP--YAWVFFIPFIFVVTFVMINLVVAI 237 >6BO5-A nrPDB Length = 695 Score = 43.7 bits (101), Expect = 4e-04, Method: Composition-based stats. Identities = 29/154 (18%), Positives = 63/154 (40%), Gaps = 16/154 (10%) Query: 541 IAYILPANESFGPLQISLGRT-VKDIFKFMVLFIMVFFAFMIGMFILY--------SYYL 591 + Y + G + + + ++D+ +F++++++ F F + + L Sbjct: 472 LLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKAPEDN 531 Query: 592 GAKVNAAFTTVEESFKTLFWSIF--GLSEVTSVVLKYDHKFIENI-----GYVLYGIYNV 644 + V T +E + SI L + + F E + +L Y + Sbjct: 532 NSTVTEQPTVGQEEEPAPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVL 591 Query: 645 TMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARS 678 V+LLNMLIA+++ + + D+S WK ++ Sbjct: 592 LTYVLLLNMLIALMSETVNHVADNSWSIWKLQKA 625 Score = 38.3 bits (87), Expect = 0.015, Method: Composition-based stats. Identities = 35/165 (21%), Positives = 54/165 (32%), Gaps = 47/165 (28%) Query: 53 LNVNCVD--YMGQNALQLAVGNEHLEVTELLLKKENLA-----------------RIGD- 92 +N C D Y G +AL +A+ L+ +LL++ G+ Sbjct: 113 VNAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGEL 172 Query: 93 ALLLAISKGYVRIVEAILNHPGFAASKRLT----------------LSPCEQELQDDDFY 136 L LA +V +L +P AS T SP L + Sbjct: 173 PLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYD 232 Query: 137 AYDEDGTRFSPDI-----------TPIILAAHCQKYEVVHMLLMK 170 + G R P + TP+ LAA K E+ +L + Sbjct: 233 GLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQR 277 >5AN8-A nrPDB Length = 613 Score = 43.3 bits (100), Expect = 5e-04, Method: Composition-based stats. Identities = 27/142 (19%), Positives = 65/142 (45%), Gaps = 6/142 (4%) Query: 538 FSRIAYILPANESFGPLQISLGRT-VKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVN 596 + + Y + G + + + ++D+ +F++++++ F F + + L S Sbjct: 432 WLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSL-SREAQEDEA 490 Query: 597 AAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIA 656 + ++ ++ LF G+ E + + +F + +L Y + V+LLNMLIA Sbjct: 491 PPYRSILDASLELFKFTIGMGE---LAFQEQLRF-RGVVLLLLLAYVLLTYVLLLNMLIA 546 Query: 657 MINSSYQEIEDDSDVEWKFARS 678 +++ + + DS WK ++ Sbjct: 547 LMSETVNSVATDSWSIWKLQKA 568 Score = 42.9 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 34/170 (20%), Positives = 54/170 (31%), Gaps = 47/170 (27%) Query: 53 LNVNCVD--YMGQNALQLAVGNEHLEVTELLLKKENLARIGD------------------ 92 +N C D Y G +AL +A+ L+ +LL++ Sbjct: 76 VNAQCTDEYYRGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGEL 135 Query: 93 ALLLAISKGYVRIVEAILNHPGFAASKRLT----------------LSPCEQELQDDDFY 136 L LA +V +L +P AAS + SP L + Sbjct: 136 PLSLAACTKQWDVVNYLLENPHPAASLQAQDSLGNTVLHALVMIADNSPENSALVVRMYD 195 Query: 137 AYDEDGTRFSPDI-----------TPIILAAHCQKYEVVHMLLMKGARIE 175 + G R P++ TP+ LAA K E+ +L + Sbjct: 196 GLLQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQREFSAP 245 >3DEO-A nrPDB Length = 183 Score = 42.9 bits (99), Expect = 6e-04, Method: Composition-based stats. Identities = 21/97 (21%), Positives = 38/97 (39%), Gaps = 9/97 (9%) Query: 24 LTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLK 83 ++ E + AA + + ++LE+ +V+ VD G+ AL G + LL + Sbjct: 41 VSEYETPWWTAARKADEQALSQLLEDR---DVDAVDENGRTALLFVAGLGSDKCVRLLAE 97 Query: 84 KENLARIGD------ALLLAISKGYVRIVEAILNHPG 114 D AL +A +VEA++ Sbjct: 98 AGADLDHRDMRGGLTALHMAAGYVRPEVVEALVELGA 134 Score = 37.5 bits (85), Expect = 0.025, Method: Composition-based stats. Identities = 17/64 (26%), Positives = 26/64 (40%), Gaps = 3/64 (4%) Query: 30 RFLDAAEYGNIPVVRKMLEESKTLNVNCVD-YMGQNALQLAVGNEHLEVTELLLKKENLA 88 L A G+ VR + E +++ D G AL +A G EV E L++ Sbjct: 79 ALLFVAGLGSDKCVRLLAEA--GADLDHRDMRGGLTALHMAAGYVRPEVVEALVELGADI 136 Query: 89 RIGD 92 + D Sbjct: 137 EVED 140 >5U0J-A nrPDB Length = 140 Score = 41.7 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 19/99 (19%), Positives = 41/99 (41%), Gaps = 8/99 (8%) Query: 20 RGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTE 79 RG+ + L AA G++ +R+ + +++ DY + AL +A H+EV + Sbjct: 17 RGSHMVKSVINLLFAAYTGDVSALRRFALSA--MDMEQRDYDSRTALHVAAAEGHVEVVK 74 Query: 80 LLLK------KENLARIGDALLLAISKGYVRIVEAILNH 112 LL+ + A+ G+ + + + + Sbjct: 75 FLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEY 113 >5U0K-A nrPDB Length = 141 Score = 41.7 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 18/114 (15%), Positives = 44/114 (38%), Gaps = 8/114 (7%) Query: 31 FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLK------K 84 L AA G++ +R+ + +++ DY + AL +A H+EV + L++ Sbjct: 29 LLFAAYSGDVSALRRFALSA--MDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPF 86 Query: 85 ENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAY 138 L A+ ++ +V+ + ++ + L ++ + Sbjct: 87 AKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLESM 140 >2NYJ-A nrPDB Length = 273 Score = 41.3 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 27/148 (18%), Positives = 49/148 (33%), Gaps = 13/148 (8%) Query: 17 FNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLN-----VNC--VD--YMGQNALQ 67 F D T T + L+ G + +L+ ++ + VN D Y GQ AL Sbjct: 48 FKDPETGKTCLLKAMLN-LHNGQNDTIALLLDVARKTDSLKQFVNASYTDSYYKGQTALH 106 Query: 68 LAVGNEHLEVTELLLKKENLARI---GDALLLAISKGYVRIVEAILNHPGFAASKRLTLS 124 +A+ ++ + LL++ + GD + E L+ + Sbjct: 107 IAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKF 166 Query: 125 PCEQELQDDDFYAYDEDGTRFSPDITPI 152 + Q D A D G + + Sbjct: 167 LLQNSWQPADISARDSVGNTVLHALVEV 194 >6OO7-A nrPDB Length = 786 Score = 41.3 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 36/208 (17%), Positives = 79/208 (37%), Gaps = 24/208 (11%) Query: 487 QYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILP 546 ++DSY + L + L Q + +W L ++ + ++ + Y Sbjct: 464 SFMDSYSEILFLLQALLTVLSQVLCFLAIEW--------YLPLLVSSLAMGWTNLLYYTR 515 Query: 547 ANESFGPLQISLGRT-VKDIFKFMVLFIMVFFAFMIGMFIL--------YSYYLGAKVNA 597 + G + + + ++D+ +F++++++ F F + + L A Sbjct: 516 GFQHTGIYSVMIEKVILRDLLRFLLVYLVFLFGFAVALVSLSREAQNSRTPAGPNATEVG 575 Query: 598 AFTTVEESFKTLFWSIF--GLSEVTSVVLKYDHKFIENI-----GYVLYGIYNVTMVVVL 650 +E + SI L + + F E + +L Y + V+L Sbjct: 576 QPGAGQEDEAPPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLL 635 Query: 651 LNMLIAMINSSYQEIEDDSDVEWKFARS 678 LNMLIA+++ + + DS WK ++ Sbjct: 636 LNMLIALMSETVNSVATDSWSIWKLQKA 663 Score = 40.6 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 34/170 (20%), Positives = 52/170 (30%), Gaps = 47/170 (27%) Query: 53 LNVNCVD--YMGQNALQLAVGNEHLEVTELLLKKENLARIGD------------------ 92 +N C D Y G +AL +A+ L+ +LL++ Sbjct: 151 VNAQCTDEYYRGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGEL 210 Query: 93 ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDED----------- 141 L LA +V +L +P AS + S L A D Sbjct: 211 PLSLAACTKQWDVVNYLLENPHQPASLQAQDSLGNTVLHALVMIADDSAENSALVVRMYD 270 Query: 142 -----GTRFSPDI-----------TPIILAAHCQKYEVVHMLLMKGARIE 175 G R P++ TP+ LAA K E+ +L + Sbjct: 271 GLLQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQREFSAP 320 >6EMK-G nrPDB Length = 426 Score = 40.6 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 31/171 (18%), Positives = 61/171 (35%), Gaps = 28/171 (16%) Query: 23 SLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLL 82 L R +A GN+ +V+++L + L N G ++L A + + L+ Sbjct: 1 MLKEPSVRLREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLI 60 Query: 83 KKENL-------ARIGDALLLAISKGYVRIVEAIL-------NHPGFAASKRLTLSPCEQ 128 + + + + LA+ KG+ + + +L NH G + ++ Sbjct: 61 QLGHDKHELIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMND 120 Query: 129 ELQ--------DDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKG 171 Q D + D +G TP+ + + MLL +G Sbjct: 121 YYQCLSLLIGVGADLWVMDTNGD------TPLHVCLEYGSISCMKMLLNEG 165 >2ETB-A nrPDB Length = 256 Score = 39.8 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 35/165 (21%), Positives = 54/165 (32%), Gaps = 47/165 (28%) Query: 53 LNVNCVD--YMGQNALQLAVGNEHLEVTELLLKKENLA-----------------RIGD- 92 +N C D Y G +AL +A+ L+ +LL++ G+ Sbjct: 79 VNAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGEL 138 Query: 93 ALLLAISKGYVRIVEAILNHPGFAASKRLT----------------LSPCEQELQDDDFY 136 L LA +V +L +P AS T SP L + Sbjct: 139 PLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYD 198 Query: 137 AYDEDGTRFSPDI-----------TPIILAAHCQKYEVVHMLLMK 170 + G R P + TP+ LAA K E+ +L + Sbjct: 199 GLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQR 243 >6AYG-A nrPDB Length = 558 Score = 39.8 bits (91), Expect = 0.005, Method: Composition-based stats. Identities = 36/292 (12%), Positives = 93/292 (31%), Gaps = 27/292 (9%) Query: 440 ECKELWLEGPREYILQLWNVLDFGMLSIFIAAFT---------------ARFLAFLQATK 484 ECK+ + G + + D ++ + + L K Sbjct: 273 ECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKK 332 Query: 485 AQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAI----AVVLSFSR 540 D + + + +I + K + S + +I + +L + Sbjct: 333 EVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLG 392 Query: 541 IAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFT 600 + L + L ++L + ++ +F M++ + +I+ + F Sbjct: 393 VIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVL-----GPYHDKFR 447 Query: 601 TVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVV--LLNMLIAMI 658 ++ + LF I G + ++ + +Y +Y+ + + +L++ IA+I Sbjct: 448 SLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIY-LYSFISLFIYMILSLFIALI 506 Query: 659 NSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMR 710 +Y+ I+ + + ++S D P S + Sbjct: 507 TDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK 558 >2F37-A nrPDB Length = 251 Score = 39.4 bits (90), Expect = 0.006, Method: Composition-based stats. Identities = 34/165 (20%), Positives = 53/165 (32%), Gaps = 47/165 (28%) Query: 53 LNVNCVD--YMGQNALQLAVGNEHLEVTELLLKKENLARIGD------------------ 92 +N C D Y G +AL +A+ L+ +LL++ Sbjct: 84 VNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGEL 143 Query: 93 ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQ----------------ELQDDDFY 136 L LA +V +L +P AS + T S L + Sbjct: 144 PLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYD 203 Query: 137 AYDEDGTRFSP-----------DITPIILAAHCQKYEVVHMLLMK 170 + G R P D+TP+ LAA K E+ +L + Sbjct: 204 GLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 248 >3T9K-A nrPDB Length = 390 Score = 39.0 bits (89), Expect = 0.009, Method: Composition-based stats. Identities = 16/64 (25%), Positives = 22/64 (34%), Gaps = 5/64 (7%) Query: 51 KTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARI-----GDALLLAISKGYVRI 105 NVN D G+ L A H + L LK+ D L +A+ I Sbjct: 257 NGANVNQADSAGRGPLHHATILGHTGLACLFLKRGADLGARDSEGRDPLTIAMETANADI 316 Query: 106 VEAI 109 V + Sbjct: 317 VTLL 320 >3W9G-A nrPDB Length = 260 Score = 37.9 bits (86), Expect = 0.019, Method: Composition-based stats. Identities = 34/181 (18%), Positives = 57/181 (31%), Gaps = 53/181 (29%) Query: 17 FNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLN-----VNC----VDYMGQNALQ 67 F + T T + L+ + G + +L+ ++ +N V Y GQ AL Sbjct: 40 FREPSTGKTCLPKALLNLS-AGRNDTIPILLDIAEKTGNMREFINSPFRDVYYRGQTALH 98 Query: 68 LAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCE 127 +A+ ELL++K A ++G Sbjct: 99 IAIERRCKHYVELLVEKGADV-------HAQARG-------------------------- 125 Query: 128 QELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKG---ARIERPHDYFCKC 184 F+ ++G F P+ LAA + +VH L G A + R D Sbjct: 126 ------RFFQPKDEGGYFYFGELPLSLAACTNQPHIVHYLTENGHKQADLRR-QDSRGNT 178 Query: 185 G 185 Sbjct: 179 V 179 >5UQE-A nrPDB Length = 520 Score = 37.9 bits (86), Expect = 0.019, Method: Composition-based stats. Identities = 17/88 (19%), Positives = 37/88 (42%), Gaps = 8/88 (9%) Query: 31 FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLK------K 84 L AA G++ +R+ + +++ DY + AL +A H+EV + LL+ Sbjct: 421 LLFAAYTGDVSALRRFALSA--MDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPF 478 Query: 85 ENLARIGDALLLAISKGYVRIVEAILNH 112 + A+ G+ + + + + Sbjct: 479 PKDRWNNTPMDEALHFGHHDVFKILQEY 506 >3KX6-A nrPDB Length = 379 Score = 37.9 bits (86), Expect = 0.019, Method: Composition-based stats. Identities = 14/54 (25%), Positives = 20/54 (37%), Gaps = 5/54 (9%) Query: 207 KGLASPAYLSLSSEDPVLTALELSNELAK-LANIEKEFKN----DYRKLSMQCK 255 K LA A S +L A E + + K N+ E +YR + K Sbjct: 32 KELAENASFIASPGKGILAADESTGTIQKRFDNVGVENTEKNRAEYRSILFTTK 85 >5HVD-A nrPDB Length = 277 Score = 37.5 bits (85), Expect = 0.027, Method: Composition-based stats. Identities = 21/170 (12%), Positives = 55/170 (32%), Gaps = 10/170 (5%) Query: 416 RVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAF--- 472 + + E + + + + +++ G R + WN+ DF +++I + Sbjct: 39 TLSASSQNLLERVDQLCLTIFIVEISLKIYAYGVRGFFRSGWNLFDFVIVAIALMPAQGS 98 Query: 473 --TARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLY 530 R + + + + + + LP + + +++ LY Sbjct: 99 LSVLRTFRIFRVMRLVSVIPTMRRVVQGMLLALPGVGSVAALLTVVFYIA--AVMATNLY 156 Query: 531 AIAVVLSF---SRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFF 577 F S+ Y L + + + R V ++ +F + F Sbjct: 157 GATFPEWFGDLSKSLYTLFQVMTLESWSMGIVRPVMNVHPNAWVFFIPFI 206 Score = 34.8 bits (78), Expect = 0.14, Method: Composition-based stats. Identities = 30/216 (13%), Positives = 69/216 (31%), Gaps = 17/216 (7%) Query: 466 SIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQII 525 I + L + + Q + V + L+ + ++ + Y + S + Sbjct: 24 IIVLNGAVLGLLTDTTLSASSQNLLERVDQLCLTIFIVEISLKIYAYGVRGFFRSGWNLF 83 Query: 526 SEGLYAIAVV-----------LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIM 574 + AIA++ R+ ++ + + + + + L + Sbjct: 84 DFVIVAIALMPAQGSLSVLRTFRIFRVMRLVSVIPTMRRVVQGMLLALPGVGSVAALLTV 143 Query: 575 VFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENI 634 VF+ + LY GA F + +S TLF + S + ++ N Sbjct: 144 VFYIAAVMATNLY----GATFPEWFGDLSKSLYTLFQVMTLESWSMGI-VRPVMNVHPNA 198 Query: 635 GYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSD 670 +T VL N+ I + + ++ + Sbjct: 199 WVFFIPFIMLTTFTVL-NLFIGICVDAMAITKEQEE 233 >4N5Q-A nrPDB Length = 257 Score = 37.5 bits (85), Expect = 0.027, Method: Composition-based stats. Identities = 36/217 (16%), Positives = 73/217 (33%), Gaps = 53/217 (24%) Query: 6 RRQAVRGPAFMFNDRGTSLTAEE---ERFLDAAEYGNIPVVRKMLEESKTLNV-----NC 57 RR+ + P F+ + S T + + L+ +VR +L ++ ++ N Sbjct: 32 RRRGLDVPDFLMHKLTASDTGKTCLMKALLN-INPNTKEIVRILLAFAEENDILDRFINA 90 Query: 58 V----DYMGQNALQLAVGNEHLEVTELLLKKENLARI-------------------GDAL 94 Y GQ AL +A+ ++T +L+ L Sbjct: 91 EYTEEAYEGQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPL 150 Query: 95 LLAISKGYVRIVEAILNHPGFAASKR----------LTLSPCEQELQDDDFYAY------ 138 LA IV+ ++ + + + L + + Q+D Sbjct: 151 ALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILL 210 Query: 139 -----DEDGTRFSPDITPIILAAHCQKYEVVHMLLMK 170 + + R + +TP+ LAA K E++ +L + Sbjct: 211 RSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSR 247 Score = 36.7 bits (83), Expect = 0.038, Method: Composition-based stats. Identities = 35/182 (19%), Positives = 60/182 (32%), Gaps = 30/182 (16%) Query: 28 EERFLDAAEYGNIPVVRKMLEESK-------TLNVN-------CVDYMGQNALQLAVGNE 73 ++R A G + +R++L++ + L+V G+ L A+ N Sbjct: 4 KKRIFAAVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTASDTGKTCLMKALLNI 63 Query: 74 H---LEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQEL 130 + E+ +LL I D + A + LN A +R Sbjct: 64 NPNTKEIVRILLAFAEENDILDRFINAEYTEEAYEGQTALN---IAIERRQGDITAVLIA 120 Query: 131 QDDDFYAYDEDGTRFSPDI---------TPIILAAHCQKYEVVHMLLMKGARIERPHDYF 181 D A+ G F+P TP+ LAA + E+V +L+ D Sbjct: 121 AGADVNAH-AKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSR 179 Query: 182 CK 183 Sbjct: 180 GN 181 >4LTR-A nrPDB Length = 152 Score = 36.7 bits (83), Expect = 0.044, Method: Composition-based stats. Identities = 25/131 (19%), Positives = 49/131 (37%), Gaps = 9/131 (6%) Query: 552 GPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFW 611 GP SL R + I +L +++F+ F + L+ F T+ S TLF Sbjct: 1 GPSSPSLLRAIPGIAWIALLLLVIFYVFAVMGTKLF----AQSFPEWFGTLGASMYTLFQ 56 Query: 612 SIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEI---EDD 668 + S + + ++ + + + +LN+ I +I S Q +D Sbjct: 57 VMTLESWSMGIARPV-IEAYPWA-WIYFVSFILVSSFTVLNLFIGIIIESMQSAGWEAED 114 Query: 669 SDVEWKFARSK 679 + + R+ Sbjct: 115 AKRIEQEQRAH 125 >3RVY-A nrPDB Length = 285 Score = 35.9 bits (81), Expect = 0.064, Method: Composition-based stats. Identities = 34/168 (20%), Positives = 67/168 (39%), Gaps = 18/168 (10%) Query: 499 SEVTLPPEIQYFTYARDKWLPSDPQIISEGL------YAIAVVLSFSRIAYILPANESFG 552 E+ L + ++ +D W D +++ L + I VL R+ ++ A Sbjct: 76 IEIILRIYVHRISFFKDPWSLFDFFVVAISLVPTSSGFEILRVLRVLRLFRLVTAVPQMR 135 Query: 553 PLQISLGRTVKDIFK---FMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTL 609 + +L + + M LF F+ F I L+ G + F T+ ESF TL Sbjct: 136 KIVSALISVIPGMLSVIALMTLF---FYIFAIMATQLF----GERFPEWFGTLGESFYTL 188 Query: 610 FWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAM 657 F + S +V + +V + + + V++N+++A+ Sbjct: 189 FQVMTLESWSMGIVRPLMEVYP--YAWVFFIPFIFVVTFVMINLVVAI 234 >4DXW-A nrPDB Length = 229 Score = 35.9 bits (81), Expect = 0.072, Method: Composition-based stats. Identities = 21/140 (15%), Positives = 58/140 (41%), Gaps = 7/140 (5%) Query: 527 EGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFIL 586 + + +L R+ ++ + ++ +V+ +F +L ++ + + IL Sbjct: 95 NSSFLVLRLLRIFRVLRLISVIPELKQIIEAILESVRRVFFVSLLLFIILYIYATMGAIL 154 Query: 587 YSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTM 646 + ++ + + S TLF + LS +V+L I +V + + + Sbjct: 155 FGNDDPSR----WGDLGISLITLFQ-VLTLSSWETVMLPMQE--IYWWSWVYFFSFIIIC 207 Query: 647 VVVLLNMLIAMINSSYQEIE 666 + +LN++IA++ + + Sbjct: 208 SITILNLVIAILVDVVIQKK 227 >6NQ0-A nrPDB Length = 756 Score = 35.6 bits (80), Expect = 0.10, Method: Composition-based stats. Identities = 40/310 (12%), Positives = 100/310 (32%), Gaps = 67/310 (21%) Query: 380 SFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWS 439 + +LG L+ A+ + + + V + F +L V+++ + Sbjct: 436 YYFDYLGNLIALANLVSICVFLVLDADVLPAERDDF--------ILGILNCVFIVYYLLE 487 Query: 440 ECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLS 499 +++ G R Y+ NV D L+ Sbjct: 488 MLLKVFALGLRGYLSYPSNVFDGL----------------------------------LT 513 Query: 500 EVTLPPEIQYFTYARDKWLPSDPQIISE----GLYAIAVVLSFSRIAYILPANESFGPLQ 555 V L EI R P+++ + + +L R I+P+ + + Sbjct: 514 VVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKPMAVVA 573 Query: 556 ISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAA----------------- 598 ++ V+++ F + ++V++ F I L+ + A + Sbjct: 574 STVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQL 633 Query: 599 --FTTVEESFKTLFWSIFGL--SEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNML 654 + + F +++ L V L ++ + + ++ + V+ +N+ Sbjct: 634 EYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLF 693 Query: 655 IAMINSSYQE 664 +A+I ++ Sbjct: 694 LALILENFLH 703 >6C96-A nrPDB Length = 825 Score = 35.2 bits (79), Expect = 0.11, Method: Composition-based stats. Identities = 47/308 (15%), Positives = 91/308 (29%), Gaps = 32/308 (10%) Query: 375 VAHAASFIIFLGL----LVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTW--TEML 428 FL ++ N+ + + + + F +K FT Sbjct: 420 WFDELPRTAFLIFKGINILVNSKAFQYFMYLVVAVNGVWILVETFMLKGGNFTSKHVPWS 479 Query: 429 IMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQY 488 +V++ ++ GP EY+ WN+ DF + + A + + Sbjct: 480 YLVFLTIYGVELFMKVAGLGPVEYLSSGWNLFDFSVTAFAFLGLLAL------TLNMEPF 533 Query: 489 VDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPAN 548 V + +Y + P++ S GL + I + N Sbjct: 534 YFIVVLRPLQLLRLFKLKKRYRNVLDTMFELL-PRMASLGLTLLT-FYYSFAIVGMEFFN 591 Query: 549 ESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKT 608 P + TV D ++F+ + G F + SF T Sbjct: 592 GRLTPNCCNTS-TVADAYRFI----------NHTVGNKTKVEEGYYYLNNFDNILNSFVT 640 Query: 609 LFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVV------LLNMLIAMINSSY 662 LF ++ ++ + Y VTMVV+ +L + +N S Sbjct: 641 LFELTV-VNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSR 699 Query: 663 QEIEDDSD 670 + + + D Sbjct: 700 KSQDSEVD 707 Score = 31.3 bits (69), Expect = 1.8, Method: Composition-based stats. Identities = 18/89 (20%), Positives = 38/89 (42%), Gaps = 6/89 (6%) Query: 580 MIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLY 639 I F L+S + F+T+E S LF + + ++ Y V + Sbjct: 248 AILGFYLFS---TNPSDPYFSTLENSIVNLFVLLTTANFPDVMMPSYSRN--PW-SCVFF 301 Query: 640 GIYNVTMVVVLLNMLIAMINSSYQEIEDD 668 +Y + ++N+L+A++ ++ +IE Sbjct: 302 IVYLSIELYFIMNLLLAVVFDTFNDIEKH 330 >1FBA-A nrPDB Length = 361 Score = 35.2 bits (79), Expect = 0.11, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 19/52 (36%), Gaps = 5/52 (9%) Query: 209 LASPAYLSLSSEDPVLTALELSNELAK-LANIEKEFKND----YRKLSMQCK 255 L A ++ +L A E + K L +I E D YR+L Sbjct: 16 LREIAQKIVAPGKGILAADESGPTMGKRLQDIGVENTEDNRRAYRQLLFSTD 67 >5HKD-A nrPDB Length = 152 Score = 34.8 bits (78), Expect = 0.15, Method: Composition-based stats. Identities = 23/113 (20%), Positives = 43/113 (38%), Gaps = 6/113 (5%) Query: 552 GPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFW 611 GP SL R + I +L +++F+ F + L+ F T+ S TLF Sbjct: 1 GPSSPSLLRAIPGIAWIALLLLVIFYVFAVMGTKLF----AQSFPEWFGTLGASMYTLFQ 56 Query: 612 SIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQE 664 + S + + ++ + + + +LN+ I +I S Q Sbjct: 57 VMTLESWSMGIARPV-IEAYPWA-WIYFVSFILVSSFTVLNLFIGIIIESMQS 107 >5TKC-A nrPDB Length = 363 Score = 34.4 bits (77), Expect = 0.21, Method: Composition-based stats. Identities = 14/54 (25%), Positives = 19/54 (35%), Gaps = 5/54 (9%) Query: 207 KGLASPAYLSLSSEDPVLTALELSNELAK-LANIEKEFKND----YRKLSMQCK 255 K LA A + +L A E + + K +I E YR L K Sbjct: 14 KELAENARKIAAPGKGILAADESTGTIKKRFDSIGVENTEANRAFYRDLLFSTK 67 >1F2J-A nrPDB Length = 370 Score = 34.0 bits (76), Expect = 0.31, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 28/71 (39%), Gaps = 13/71 (18%) Query: 200 RSRINAYKGLASP--------AYLSLSSEDPVLTALELSNELAK-LANIEKEFKND---- 246 +++ AY L +P A + +L A E + +K A I + Sbjct: 8 LTQLPAYNRLKTPYEAELIETAKKMTAPGKGLLAADESTGSCSKRFAGIGLSNTAEHRRQ 67 Query: 247 YRKLSMQCKDF 257 YR L ++C+ F Sbjct: 68 YRALMLECEGF 78 >6EM5-I nrPDB Length = 663 Score = 33.6 bits (75), Expect = 0.38, Method: Composition-based stats. Identities = 15/53 (28%), Positives = 31/53 (58%), Gaps = 1/53 (1%) Query: 782 KENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSMLR 834 KE++ E ++ ++K+DI+ L +++E+ + T L L K+ E NP+ + Sbjct: 124 KEDEPDTEEKILQLKEDIADLVTKVMEEPEENTAALGRLC-KMVESKNPNTCK 175 >4DX2-A nrPDB Length = 259 Score = 33.3 bits (74), Expect = 0.42, Method: Composition-based stats. Identities = 26/148 (17%), Positives = 45/148 (30%), Gaps = 13/148 (8%) Query: 17 FNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLN-----VNC----VDYMGQNALQ 67 F + T T + L+ + G + +L+ ++ +N + Y GQ AL Sbjct: 38 FREPSTGKTCLPKALLNLSN-GRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALH 96 Query: 68 LAVGNEHLEVTELLLKKENLARI---GDALLLAISKGYVRIVEAILNHPGFAASKRLTLS 124 +A+ ELL+ + G GY E L+ + Sbjct: 97 IAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNY 156 Query: 125 PCEQELQDDDFYAYDEDGTRFSPDITPI 152 E + D D G + I Sbjct: 157 LTENPHKKADMRRQDSRGNTVLHALVAI 184 >5O0W-A nrPDB Length = 387 Score = 32.9 bits (73), Expect = 0.55, Method: Composition-based stats. Identities = 14/66 (21%), Positives = 26/66 (39%), Gaps = 5/66 (7%) Query: 197 SHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAK-LANIEKEFKND----YRKLS 251 +++R + + L A + +L A E + +K A I + YR L Sbjct: 14 AYNRLKTPYEEELIETAKKMTAPGKGLLAADESTGSCSKRFAGIGLSNTAEHRRQYRALM 73 Query: 252 MQCKDF 257 ++C F Sbjct: 74 LECAGF 79 >4BSZ-B nrPDB Length = 202 Score = 31.7 bits (70), Expect = 1.2, Method: Composition-based stats. Identities = 17/93 (18%), Positives = 33/93 (35%), Gaps = 18/93 (19%) Query: 35 AEYGNIPVVR---KMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIG 91 A G++ ++ L + L+ AL +A N H+E +L+ + A Sbjct: 22 ARAGDLDSLKDIFTTLVSPELLSTCKESESDSTALHMAAANGHIETVRYILETVSRANSA 81 Query: 92 D---------------ALLLAISKGYVRIVEAI 109 + AL A G + +V+ + Sbjct: 82 EDLKAFVNEVNKTGNTALHWASLNGKLDVVKLL 114 >6CXH-C nrPDB Length = 250 Score = 31.3 bits (69), Expect = 1.6, Method: Composition-based stats. Identities = 22/197 (11%), Positives = 57/197 (28%), Gaps = 8/197 (4%) Query: 369 SPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEML 428 +P + +I + ++ + + ++ P++ R T +TW M Sbjct: 54 APEFETYWMNFLYIEMVLEVLTASVLWGYIWKSRDRKVMSITPREELRRHFTHWTWLMMY 113 Query: 429 IMVWVLG--MMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQ 486 + G + R+ ++++F + + A K + Sbjct: 114 GIAIYFGASYFTEQDGTWHQTIVRDTDFTPSHIIEFYLSYPI---YIITGGASFLYAKTR 170 Query: 487 QYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIA---VVLSFSRIAY 543 V + P + ++W + + + + V +S + Sbjct: 171 LPTYQQGLSLQYLVVVVGPFMILPNVGLNEWGHTFWFMEELFVAPLHYGFVFFGWSALGV 230 Query: 544 ILPANESFGPLQISLGR 560 + N G L L + Sbjct: 231 LGVINIELGALSKLLKK 247 >5E1J-A nrPDB Length = 741 Score = 30.9 bits (68), Expect = 2.6, Method: Composition-based stats. Identities = 45/319 (14%), Positives = 91/319 (28%), Gaps = 61/319 (19%) Query: 347 GLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNIT 406 Y A +L +RSP + A SFI+ + + T + Sbjct: 407 LFEHFPQIYHSALSQQLRAFVRSPNFGY---AISFILIINFIAVVVE-----TTLDIEES 458 Query: 407 VTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLS 466 P Q+ V+ + +++ G Y + N DF + Sbjct: 459 SAQKPWQVAE-------------FVFGWIYVLEMALKIYTYGFENYWREGANRFDFLVTW 505 Query: 467 IFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIIS 526 + + TA F + + + + I+Y AR Sbjct: 506 VIVIGETATF----------------ITPDENTFFSNGEWIRYLLLAR------------ 537 Query: 527 EGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIM----VFFAFMIG 582 + ++ + +F L SL + IF + ++ VF + Sbjct: 538 ----MLRLIRLLMNVQRYRAFIATFITLIPSLMPYLGTIFCVLCIYCSIGVQVFGGLVNA 593 Query: 583 MFILYSYYLGAKVN---AAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLY 639 A+ + F TLF + + + Y + Sbjct: 594 GNKKLFETELAEDDYLLFNFNDYPNGMVTLFNLLVMGNW-QVWMESYKDLTGTWWSITYF 652 Query: 640 GIYNVTMVVVLLNMLIAMI 658 + V +++LLN+++A + Sbjct: 653 VSFYVITILLLLNLVVAFV 671 >6BQH-A nrPDB Length = 452 Score = 30.6 bits (67), Expect = 2.8, Method: Composition-based stats. Identities = 22/124 (17%), Positives = 46/124 (37%), Gaps = 18/124 (14%) Query: 261 VLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLT 320 + D DS E++ D + V + +L KLA + +VK+ A +Q T Sbjct: 280 LEDKSPDSPEMK-----DFRHGFDILVGQIDDAL---KLANEGKVKE--AQAAAEQLKTT 329 Query: 321 I------WYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRL--GKILRSPFM 372 + + ++ R+ + + + + + + PF C + K++ Sbjct: 330 RNAYIQKYLQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLN 389 Query: 373 KFVA 376 FV Sbjct: 390 VFVW 393 >3EU9-A nrPDB Length = 240 Score = 30.6 bits (67), Expect = 2.9, Method: Composition-based stats. Identities = 11/47 (23%), Positives = 15/47 (31%) Query: 150 TPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSF 196 TP+ A +V L+ GA C C + H S Sbjct: 78 TPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSI 124 >3LVQ-E nrPDB Length = 497 Score = 30.6 bits (67), Expect = 3.2, Method: Composition-based stats. Identities = 19/85 (22%), Positives = 33/85 (38%), Gaps = 6/85 (7%) Query: 32 LDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLA--- 88 + A ++P+V +++ L+ D G AL A + +LLLK L Sbjct: 179 VKVANQASLPLVDFIIQNGGHLDAKAAD--GNTALHYAALYNQPDCLKLLLKGRALVGTV 236 Query: 89 -RIGDALLLAISKGYVRIVEAILNH 112 G+ L K + + E +L Sbjct: 237 NEAGETALDIARKKHHKECEELLEQ 261 >2B0O-E nrPDB Length = 301 Score = 30.6 bits (67), Expect = 3.2, Method: Composition-based stats. Identities = 19/85 (22%), Positives = 33/85 (38%), Gaps = 6/85 (7%) Query: 32 LDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLA--- 88 + A ++P+V +++ L+ D G AL A + +LLLK L Sbjct: 198 VKVANQASLPLVDFIIQNGGHLDAKAAD--GNTALHYAALYNQPDCLKLLLKGRALVGTV 255 Query: 89 -RIGDALLLAISKGYVRIVEAILNH 112 G+ L K + + E +L Sbjct: 256 NEAGETALDIARKKHHKECEELLEQ 280 >3JC6-4 nrPDB Length = 933 Score = 30.2 bits (66), Expect = 3.6, Method: Composition-based stats. Identities = 20/86 (23%), Positives = 42/86 (48%), Gaps = 9/86 (10%) Query: 742 QSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISS 801 ++ R+ + +F SI + Q+++K L K YV V K +D K + D S+ Sbjct: 428 RAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVSD-------KRLDVDTST 480 Query: 802 LRYELLEDKSQATEELAILIHKLSEK 827 + EL+++K E + +++++ Sbjct: 481 IEQELMQNKVDHNE--VEEVRQITDQ 504 >3WOM-A nrPDB Length = 698 Score = 30.2 bits (66), Expect = 4.2, Method: Composition-based stats. Identities = 14/86 (16%), Positives = 35/86 (40%), Gaps = 6/86 (6%) Query: 710 RIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQI--- 766 ++++ + + +D+ + + N+ + L TQ E N+ + + + Sbjct: 354 KLLDLLEQSKATRDRDLTLALFNNTAMLGSATQLYRLSIEREKPNAERESGYQERDLPAI 413 Query: 767 ---MKRLIKRYVLKAQVDKENDEVNE 789 +K+L +RYV + +NE Sbjct: 414 EGGLKQLERRYVAAMDRQLQEYWLNE 439 >6IRX-A nrPDB Length = 496 Score = 29.8 bits (65), Expect = 4.9, Method: Composition-based stats. Identities = 21/113 (18%), Positives = 47/113 (41%), Gaps = 8/113 (7%) Query: 187 CMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSE--DPVLTAL---ELSNELA-KLANIE 240 C +++ + S +R + + L DPV++ E+ N++ +L+ I Sbjct: 47 CSQREGIEPPRESFNRWLLERKVVDKGLDPLLPSECDPVISPSMFREIMNDIPIRLSRI- 105 Query: 241 KEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKAS 293 ++K + RKL + + ++D + E ++ ++E H AS Sbjct: 106 -KYKEEARKLLFKYAEAAKKMIDSRNVTPESRKVVKWNVEDTMNWLRRDHSAS 157 >4KP2-A nrPDB Length = 441 Score = 29.8 bits (65), Expect = 5.3, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 28/71 (39%), Gaps = 8/71 (11%) Query: 163 VVHMLLMKGARIERP--------HDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAY 214 ++ + + GA I P H G+ + +F IN+Y LASP Sbjct: 367 IIDIFVKAGAMICTPGCGPCLGAHQGVLAEGEICLSTTNRNFKGRMGHINSYIYLASPKI 426 Query: 215 LSLSSEDPVLT 225 ++S+ +T Sbjct: 427 AAISAVKGYIT 437 >4S1L-A nrPDB Length = 237 Score = 29.4 bits (64), Expect = 7.3, Method: Composition-based stats. Identities = 13/36 (36%), Positives = 18/36 (50%) Query: 293 SLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSG 328 SL R++ Y+ KFV P+C + WY L G Sbjct: 134 SLDRIRPPCSYKRNKFVDLPSCGGRCEKAWYVELDG 169 >5UIL-A nrPDB Length = 405 Score = 29.0 bits (63), Expect = 8.5, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 19/36 (52%), Gaps = 1/36 (2%) Query: 150 TPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCG 185 +P+I+AA+ E++ L+ KGA I +Y Sbjct: 313 SPVIVAAYHGNIELIKWLVSKGANI-NDRNYKGTTV 347 >4XD0-A nrPDB Length = 417 Score = 29.0 bits (63), Expect = 9.0, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 18/36 (50%), Gaps = 1/36 (2%) Query: 150 TPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCG 185 +PII+AA+ +V+ L+ KG I +Y Sbjct: 326 SPIIIAAYHGNMDVIEWLVSKGVNI-NDRNYKGTTV 360 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.315 0.122 0.305 Lambda K H 0.267 0.0373 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 26,477,822 Number of Sequences: 36641 Number of extensions: 955137 Number of successful extensions: 3637 Number of sequences better than 10.0: 112 Number of HSP's better than 10.0 without gapping: 107 Number of HSP's successfully gapped in prelim test: 60 Number of HSP's that attempted gapping in prelim test: 2952 Number of HSP's gapped (non-prelim): 355 length of query: 836 length of database: 10,336,785 effective HSP length: 105 effective length of query: 731 effective length of database: 6,489,480 effective search space: 4743809880 effective search space used: 4743809880 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 63 (29.0 bits)