BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q13217 (504 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2Y4T-A nrPDB 850 0.0 4J80-A nrPDB 69 3e-12 4WB7-A nrPDB 61 9e-10 5AYL-A nrPDB 57 1e-08 3APQ-A nrPDB 57 2e-08 6FO1-G nrPDB 54 2e-07 3LZ8-A nrPDB 52 9e-07 6N3Q-D nrPDB 49 6e-06 2L6L-A nrPDB 47 3e-05 1W3B-A nrPDB 42 5e-04 1IHG-A nrPDB 41 0.001 5JHE-A nrPDB 39 0.005 5OMP-A nrPDB 38 0.010 6B85-J nrPDB 38 0.010 1KT1-A nrPDB 37 0.019 5JJT-A nrPDB 36 0.035 6FRK-r nrPDB 36 0.045 5MGX-E nrPDB 35 0.087 5WRW-A nrPDB 35 0.088 5ZYQ-A nrPDB 33 0.22 2C2L-A nrPDB 33 0.23 1A17-A nrPDB 33 0.34 4JA9-A nrPDB 33 0.39 5Y88-T nrPDB 32 0.64 1QZ2-A nrPDB 31 1.00 5G04-X nrPDB 31 1.4 3MKR-B nrPDB 30 2.2 6C90-A nrPDB 30 2.8 5LNK-l nrPDB 30 3.2 5A01-A nrPDB 29 4.3 4KYI-A nrPDB 29 4.4 1YKW-A nrPDB 29 4.6 5LDX-e nrPDB 29 4.7 6FYY-p nrPDB 29 4.8 3LL3-A nrPDB 29 5.9 5WM0-A nrPDB 28 7.3 4IT5-A nrPDB 28 9.3 >2Y4T-A nrPDB Length = 450 Score = 850 bits (2195), Expect = 0.0, Method: Compositional matrix adjust. Identities = 431/440 (97%), Positives = 431/440 (97%) Query: 22 VDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVF 81 VDL E ADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVF Sbjct: 11 VDLGTENLYFQSMADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVF 70 Query: 82 LAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEE 141 LAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEE Sbjct: 71 LAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEE 130 Query: 142 KEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKE 201 KEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKE Sbjct: 131 KEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKE 190 Query: 202 GEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAH 261 GEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAH Sbjct: 191 GEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAH 250 Query: 262 YKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEK 321 YKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEK Sbjct: 251 YKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEK 310 Query: 322 PVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLE 381 PVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLE Sbjct: 311 PVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLE 370 Query: 382 KAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFID 441 KAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFID Sbjct: 371 KAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFID 430 Query: 442 IAAAKEVLSDPEMRKKFDDG 461 IAAAKEVLSDPEMRKKFDDG Sbjct: 431 IAAAKEVLSDPEMRKKFDDG 450 >4J80-A nrPDB Length = 284 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 35/70 (50%), Positives = 50/70 (71%), Gaps = 4/70 (5%) Query: 390 SQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVL 449 + K+DYY ILGV RNA ++EI +AY++LA Q+HPD ++ E AE+KF +I A V+ Sbjct: 2 AAKKDYYAILGVPRNATQEEIKRAYKRLARQYHPDVNKSPE----AEEKFKEINEAYAVM 57 Query: 450 SDPEMRKKFD 459 SDPE R+ +D Sbjct: 58 SDPEKRRIYD 67 >4WB7-A nrPDB Length = 405 Score = 61.2 bits (147), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 34/67 (50%), Positives = 48/67 (71%), Gaps = 4/67 (5%) Query: 393 RDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDP 452 +DYY+ LG+ R A +EI +AYR+ AL++HPD +N+E AE+KF +IA A +VLSDP Sbjct: 2 KDYYQTLGLARGASDEEIKRAYRRQALRYHPD--KNKE--PGAEEKFKEIAEAYDVLSDP 57 Query: 453 EMRKKFD 459 R+ FD Sbjct: 58 RKREIFD 64 >5AYL-A nrPDB Length = 783 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 35/82 (42%), Positives = 49/82 (59%), Gaps = 6/82 (7%) Query: 393 RDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDP 452 +++Y +LGV + A +EI +A++KLAL+ HPD N A F+ I A EVL D Sbjct: 24 QNFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPN---NPNAHGDFLKINRAYEVLKDE 80 Query: 453 EMRKKFDD-GEDPLDAESQQGG 473 ++RKK+D GE L E QGG Sbjct: 81 DLRKKYDKYGEKGL--EDNQGG 100 >3APQ-A nrPDB Length = 210 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 37/95 (38%), Positives = 55/95 (57%), Gaps = 10/95 (10%) Query: 393 RDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDP 452 +++Y +LGV + A +EI +A++KLAL+ HPD N A F+ I A EVL D Sbjct: 2 QNFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPN---NPNAHGDFLKINRAYEVLKDE 58 Query: 453 EMRKKFDD-GEDPLDAESQQGGGGNPFHRSWNSWQ 486 ++RKK+D GE L E QGG + SW+ ++ Sbjct: 59 DLRKKYDKYGEKGL--EDNQGGQ----YESWSYYR 87 >6FO1-G nrPDB Length = 665 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 69/291 (23%), Positives = 115/291 (39%), Gaps = 44/291 (15%) Query: 32 GVNADVEKHLEL---GKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSK 88 G++ D +K L L G K G+ +A+ + +D DP N + RA+ + + K Sbjct: 125 GIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFA 184 Query: 89 AALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPS----------- 137 A D + L +T A +RG KL+EA+ D+++VL+ P+ Sbjct: 185 VAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKI 244 Query: 138 -------ENEEKEAQSQLIKSDEMQRL-------RSQALNA-------FGSGDYTAAIAF 176 EN + +IKS E +R + QA++ F G Y AI Sbjct: 245 SQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIEC 304 Query: 177 LDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLG 236 + + +A L RA ++K + +A D A L ++AF + T LG Sbjct: 305 YTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLG 364 Query: 237 DHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDA 287 + + L L+ +K+ ++KK ELI G + D Sbjct: 365 KLNEAKQDFETVLLLEPGNKQAVTELSKIKK---------ELIEKGHWDDV 406 >3LZ8-A nrPDB Length = 329 Score = 51.6 bits (122), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 29/67 (43%), Positives = 41/67 (61%), Gaps = 4/67 (5%) Query: 393 RDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDP 452 +DYY ILGV+ + I AYR+LA ++HPD ++ AE KF D+A A EVL D Sbjct: 28 KDYYAILGVQPTDDLKTIKTAYRRLARKYHPD----VSKENDAEAKFKDLAEAWEVLKDE 83 Query: 453 EMRKKFD 459 + R ++D Sbjct: 84 QRRAEYD 90 >6N3Q-D nrPDB Length = 663 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 28/87 (32%), Positives = 46/87 (52%), Gaps = 3/87 (3%) Query: 394 DYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQ---NEEEKKKAEKKFIDIAAAKEVLS 450 D Y+ILG+ +A ++I AYRKL++++HPD +EK E+ ++ I A E L+ Sbjct: 125 DPYEILGISTSASDRDIKSAYRKLSVKFHPDKLAKGLTPDEKSVMEETYVQITKAYESLT 184 Query: 451 DPEMRKKFDDGEDPLDAESQQGGGGNP 477 D +R+ + P +S G P Sbjct: 185 DELVRQNYLKYGHPDGPQSTSHGIALP 211 >2L6L-A nrPDB Length = 155 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 24/76 (31%), Positives = 44/76 (57%), Gaps = 3/76 (3%) Query: 387 LKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAE---KKFIDIA 443 ++Q K+D+Y ILG +A ++ + Y+KL L +HPD + E +KFI+I Sbjct: 4 VEQMPKKDWYSILGADPSANISDLKQKYQKLILMYHPDKQSTDVPAGTVEECVQKFIEID 63 Query: 444 AAKEVLSDPEMRKKFD 459 A ++L + E ++++D Sbjct: 64 QAWKILGNEETKREYD 79 >1W3B-A nrPDB Length = 388 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 27/100 (27%), Positives = 45/100 (45%) Query: 38 EKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKV 97 E + LG GQL +A+ + A+ PD Y A +A G + A+ Sbjct: 68 EAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSA 127 Query: 98 IQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPS 137 +Q D R G+LL G+L+EA+ + K +++ P+ Sbjct: 128 LQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPN 167 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 57/285 (20%), Positives = 115/285 (40%), Gaps = 28/285 (9%) Query: 37 VEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTK 96 ++ ++ L L+AAG + A+ + +A+ +PD Y + A+G+ + A K Sbjct: 101 IDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLK 160 Query: 97 VIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQR 156 I+ + +F A G + QG++ A F+K + +P+ + ++K + Sbjct: 161 AIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARI-- 218 Query: 157 LRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASK 216 + A+A + L + A + A + ++G AI + A + Sbjct: 219 -------------FDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIE 265 Query: 217 LKNDNTEAFYKISTLYYQLGDHELSLSEVREC----LKLDQDHKRCFAHYKQVKKLNKLI 272 L+ +A+ ++ + G S++E +C L+L H + +K+ I Sbjct: 266 LQPHFPDAYCNLANALKEKG----SVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNI 321 Query: 273 ESAEELIRDG-----RYTDATSKYESVMKTEPSIAEYTVRSKERI 312 E A L R + A S SV++ + + E + KE I Sbjct: 322 EEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAI 366 >1IHG-A nrPDB Length = 370 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 22/70 (31%), Positives = 40/70 (57%) Query: 325 AIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQ 384 A+ C E L+++P N AL RA+ + + YD+A+ D + AQE D+ I+ L K + Sbjct: 292 AVDSCLEALEIDPSNTKALYRRAQGWQGLKEYDQALADLKKAQEIAPEDKAIQAELLKVK 351 Query: 385 RLLKQSQKRD 394 + +K + ++ Sbjct: 352 QKIKAQKDKE 361 >5JHE-A nrPDB Length = 397 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 22/74 (29%), Positives = 43/74 (58%), Gaps = 4/74 (5%) Query: 324 EAIRVCSEVLQMEP----DNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREG 379 +AI + +L+M+ D A R +YL ++ DEA+QDY +E N +D+ I + Sbjct: 314 DAIMYATYLLEMDNVPNRDQAKAYYRRGNSYLKKKRLDEALQDYIFCKEKNPDDEVIEQR 373 Query: 380 LEKAQRLLKQSQKR 393 +E RL+++++++ Sbjct: 374 IEYVNRLIEENKEK 387 >5OMP-A nrPDB Length = 462 Score = 38.1 bits (87), Expect = 0.010, Method: Compositional matrix adjust. Identities = 28/127 (22%), Positives = 56/127 (44%), Gaps = 11/127 (8%) Query: 279 IRDGRYTDATSKYESV---MKTEPSIAEYTVRSKE--------RICHCFSKDEKPVEAIR 327 + G+Y A +Y + ++ E ++E ++ E + C+ K + +A+ Sbjct: 284 FKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVE 343 Query: 328 VCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLL 387 C + L ++ N L R EA L+ ++ A D+E E N ++ R + Q+ Sbjct: 344 CCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKA 403 Query: 388 KQSQKRD 394 K+ +RD Sbjct: 404 KEHNERD 410 >6B85-J nrPDB Length = 223 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 23/81 (28%), Positives = 45/81 (55%) Query: 60 FHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQG 119 + A++ DP++ +A+ +V + + A K I+LK + +A + G +L K G Sbjct: 104 YKKAIELDPNDALAWLLLGSVLEKLKRLDEAAEAYKKAIELKPNDASAWKELGKVLEKLG 163 Query: 120 KLDEAEDDFKKVLKSNPSENE 140 +LDEA + +KK ++ +P + E Sbjct: 164 RLDEAAEAYKKAIELDPEDAE 184 Score = 33.5 bits (75), Expect = 0.23, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 50/100 (50%) Query: 41 LELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQL 100 L LG L +L +A + A++ P++ A+ V +G+ A K I+L Sbjct: 119 LLLGSVLEKLKRLDEAAEAYKKAIELKPNDASAWKELGKVLEKLGRLDEAAEAYKKAIEL 178 Query: 101 KMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENE 140 + A + G +L K G+LDEA + +KK ++ +P++ E Sbjct: 179 DPEDAEAWKELGKVLEKLGRLDEAAEAYKKAIELDPNDLE 218 >1KT1-A nrPDB Length = 457 Score = 37.0 bits (84), Expect = 0.019, Method: Compositional matrix adjust. Identities = 28/127 (22%), Positives = 56/127 (44%), Gaps = 11/127 (8%) Query: 279 IRDGRYTDATSKYESV---MKTEPSIAEYTVRSKE--------RICHCFSKDEKPVEAIR 327 + G+Y A +Y + ++ E ++E ++ E + C+ K + +A+ Sbjct: 279 FKGGKYVQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVE 338 Query: 328 VCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLL 387 C + L ++ N L R EA L+ ++ A D+E E N ++ R + Q+ Sbjct: 339 CCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQIFMCQKKA 398 Query: 388 KQSQKRD 394 K+ +RD Sbjct: 399 KEHNERD 405 >5JJT-A nrPDB Length = 479 Score = 36.2 bits (82), Expect = 0.035, Method: Compositional matrix adjust. Identities = 23/108 (21%), Positives = 53/108 (49%), Gaps = 3/108 (2%) Query: 34 NADVEKHLEL---GKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAA 90 N+DV + E + + + A+ + A++ + +N + + RA + + +A Sbjct: 3 NSDVSRAEEFKSQANEAFKGHKYSSAIDLYTKAIELNSNNAVYWANRAFAHTKLEEYGSA 62 Query: 91 LPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSE 138 + D +K I++ ++ +RG L GK +A DF++V + +P++ Sbjct: 63 IQDASKAIEVDSRYSKGYYRRGAAYLAMGKFKDALKDFQQVKRLSPND 110 >6FRK-r nrPDB Length = 605 Score = 35.8 bits (81), Expect = 0.045, Method: Compositional matrix adjust. Identities = 18/67 (26%), Positives = 39/67 (58%), Gaps = 1/67 (1%) Query: 162 LNAFG-SGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKND 220 +N +G +GD+T A+ ++KIL++ D + C I+ G ++A++ + +K+ + Sbjct: 18 VNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLAN 77 Query: 221 NTEAFYK 227 N+ +F K Sbjct: 78 NSLSFEK 84 >5MGX-E nrPDB Length = 290 Score = 35.0 bits (79), Expect = 0.087, Method: Compositional matrix adjust. Identities = 26/82 (31%), Positives = 40/82 (48%), Gaps = 9/82 (10%) Query: 325 AIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEK-- 382 A+R CS VL+ +PDN+ AL + + + Y EAI A + +++ I L K Sbjct: 201 ALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLV 260 Query: 383 ----AQRLLKQSQKRDYYKILG 400 AQR ++ Y K+LG Sbjct: 261 KKHAAQR---STETALYRKMLG 279 Score = 32.7 bits (73), Expect = 0.41, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 36/75 (48%) Query: 88 KAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQ 147 +AAL + V++ + D A ++G +L +QG+ EA + LK PS S+ Sbjct: 199 RAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSK 258 Query: 148 LIKSDEMQRLRSQAL 162 L+K QR AL Sbjct: 259 LVKKHAAQRSTETAL 273 Score = 28.5 bits (62), Expect = 8.0, Method: Compositional matrix adjust. Identities = 24/95 (25%), Positives = 37/95 (38%), Gaps = 5/95 (5%) Query: 48 LAAGQLA-----DALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKM 102 LAA QL AL ++ PDN A +R+ V G+ A+P L ++L+ Sbjct: 188 LAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEP 247 Query: 103 DFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPS 137 + L+ K E + + NPS Sbjct: 248 SNKTIHAELSKLVKKHAAQRSTETALYRKMLGNPS 282 >5WRW-A nrPDB Length = 163 Score = 34.7 bits (78), Expect = 0.088, Method: Compositional matrix adjust. Identities = 18/67 (26%), Positives = 39/67 (58%), Gaps = 1/67 (1%) Query: 162 LNAFG-SGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKND 220 +N +G +GD+T A+ ++KIL++ D + C I+ G ++A++ + +K+ + Sbjct: 18 VNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLAN 77 Query: 221 NTEAFYK 227 N+ +F K Sbjct: 78 NSLSFEK 84 >5ZYQ-A nrPDB Length = 320 Score = 33.5 bits (75), Expect = 0.22, Method: Compositional matrix adjust. Identities = 25/90 (27%), Positives = 41/90 (45%), Gaps = 1/90 (1%) Query: 47 LLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTA 106 LL ++ A +QFH ++ P+N A +A + + AL K ++ A Sbjct: 139 LLEGDKMDQADAQFHFVLNQSPNNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPA 198 Query: 107 -ARLQRGHLLLKQGKLDEAEDDFKKVLKSN 135 RL GH +K KL++A F + L+ N Sbjct: 199 EVRLGMGHCFVKLNKLEKARLAFSRALELN 228 >2C2L-A nrPDB Length = 281 Score = 33.5 bits (75), Expect = 0.23, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 46/98 (46%), Gaps = 6/98 (6%) Query: 270 KLIESAEELIRDGRYTDATSKYESVMKTEPSIA-EYTVRSKERICHCFSKDEKPVEAIRV 328 +L E L +Y +A + Y + P +A YT R+ C+ K ++P +A+ Sbjct: 6 ELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRAL-----CYLKMQQPEQALAD 60 Query: 329 CSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETA 366 C L+++ +V A + L E YDEAI + + A Sbjct: 61 CRRALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRA 98 >1A17-A nrPDB Length = 166 Score = 32.7 bits (73), Expect = 0.34, Method: Compositional matrix adjust. Identities = 18/46 (39%), Positives = 26/46 (56%) Query: 56 ALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLK 101 AL A++ D YYRRA +A+GK +AAL D V+++K Sbjct: 66 ALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVK 111 >4JA9-A nrPDB Length = 488 Score = 32.7 bits (73), Expect = 0.39, Method: Compositional matrix adjust. Identities = 19/55 (34%), Positives = 31/55 (56%) Query: 56 ALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQ 110 AL A++ D YYRRA +A+GK +AAL D V+++K + A+++ Sbjct: 70 ALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPNDKDAKMK 124 Score = 29.6 bits (65), Expect = 3.6, Method: Compositional matrix adjust. Identities = 33/121 (27%), Positives = 58/121 (47%), Gaps = 10/121 (8%) Query: 293 SVMKTEPSIAEYTVRSKERI---CHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEA 349 S M+ EP AE T++ E + + + K + AI+ S+ +++ P N +R+ A Sbjct: 2 SHMRDEPP-AEGTLKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLA 60 Query: 350 YLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLLK----QSQKRDYYKILGVKRNA 405 YL E Y A+ D A E ++ + I+ +A + ++ RDY ++ VK N Sbjct: 61 YLRTECYGYALGDATRAIELDK--KYIKGYYRRAASNMALGKFRAALRDYETVVKVKPND 118 Query: 406 K 406 K Sbjct: 119 K 119 >5Y88-T nrPDB Length = 283 Score = 32.0 bits (71), Expect = 0.64, Method: Compositional matrix adjust. Identities = 15/51 (29%), Positives = 28/51 (54%), Gaps = 3/51 (5%) Query: 409 EIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDPEMRKKFD 459 +I + YR LAL++HPD + KF ++ A +L++ ++R +D Sbjct: 37 QIKRKYRTLALKYHPD---KHPDNPSIIHKFHLLSTATNILTNADVRPHYD 84 >1QZ2-A nrPDB Length = 336 Score = 31.2 bits (69), Expect = 1.00, Method: Compositional matrix adjust. Identities = 21/71 (29%), Positives = 33/71 (46%) Query: 40 HLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQ 99 HL L L + A+ + A++ D +N +RR LA+ + A D KV+Q Sbjct: 199 HLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQ 258 Query: 100 LKMDFTAARLQ 110 L + AA+ Q Sbjct: 259 LYPNNKAAKTQ 269 Score = 28.1 bits (61), Expect = 8.7, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 36/79 (45%), Gaps = 9/79 (11%) Query: 291 YESVMKTEPSIAEYTVR--SKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAE 348 YES E + +R S + C K + AI C++ L+++ +N L R E Sbjct: 179 YESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGE 238 Query: 349 AYLIEEMYDEAIQDYETAQ 367 A+L A+ D+E A+ Sbjct: 239 AHL-------AVNDFELAR 250 >5G04-X nrPDB Length = 599 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 49/220 (22%), Positives = 90/220 (40%), Gaps = 26/220 (11%) Query: 128 FKKVLKSNPSENEEKEAQSQL-IKSDEMQRLRSQALNAFGSGDYTA-AIAFLDKILEVCV 185 +KK + PS KE Q + D + L S ++ T I + + + V Sbjct: 179 YKKAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSV 238 Query: 186 WDAELRELRAECFIKEGEPRKAISDLKAASK--LKNDNTEAFYKISTLYYQLGDHELSLS 243 W ++A F+ G+ +AIS + + K L DN + ++ LY++ GD++ S+ Sbjct: 239 W------IKAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVL 292 Query: 244 EVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAE 303 + + LD + Y + L R+GR D + + AE Sbjct: 293 KFEQAQMLDPYLIKGMDVYGYL------------LAREGRLEDVENLGCRLFNISDQHAE 340 Query: 304 YTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNAL 343 V S CH F ++ A+ + ++ +Q+ ++V AL Sbjct: 341 PWVVSG---CHSF-YSKRYSRALYLGAKAIQLNSNSVQAL 376 >3MKR-B nrPDB Length = 320 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 19/62 (30%), Positives = 34/62 (54%), Gaps = 3/62 (4%) Query: 89 AALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNP---SENEEKEAQ 145 A L + + LK++ RLQ + L GK +EA + F+ +L S P +N+++ A+ Sbjct: 86 AGLKNGVPAVGLKLNDLIQRLQLCYQLTTVGKFEEAVEKFRSILLSVPLLVVDNKQEIAE 145 Query: 146 SQ 147 +Q Sbjct: 146 AQ 147 >6C90-A nrPDB Length = 734 Score = 30.0 bits (66), Expect = 2.8, Method: Compositional matrix adjust. Identities = 37/154 (24%), Positives = 69/154 (44%), Gaps = 17/154 (11%) Query: 302 AEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQ 361 AE+ ++ CH D +P + + D ++ + D + E+ ++ A+Q Sbjct: 226 AEWICHLHKQPCHVIYTDYRPTP---LQHYIFPAGGDGLHLVVDENGDFR-EDNFNTAMQ 281 Query: 362 DYETAQEHNENDQQIREGLEKAQ----RLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKL 417 A + + DQ+ R+G K +++K +R++ ++ + K E AY Sbjct: 282 VLRDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCE---AY--- 335 Query: 418 ALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSD 451 ALQ +F +EEKK E+ F + A + LSD Sbjct: 336 ALQMTKLDFNTDEEKKMVEEVF---SNAIDCLSD 366 >5LNK-l nrPDB Length = 105 Score = 29.6 bits (65), Expect = 3.2, Method: Compositional matrix adjust. Identities = 14/45 (31%), Positives = 26/45 (57%) Query: 241 SLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYT 285 S+ +EC +D + C K +K+LN + ++LI++G+YT Sbjct: 48 SIRAEKECKIEFEDFRECLLRQKTMKRLNAIKRQRDKLIKEGKYT 92 >5A01-A nrPDB Length = 710 Score = 29.3 bits (64), Expect = 4.3, Method: Compositional matrix adjust. Identities = 30/134 (22%), Positives = 56/134 (41%), Gaps = 15/134 (11%) Query: 96 KVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQ 155 K +++ DF AA +L +QGKL EA +K+ ++ P+ + +K E+Q Sbjct: 32 KALEVFPDFAAAHSNLASVLQQQGKLKEALMHYKEAIRIQPTFADAYSNMGNTLK--ELQ 89 Query: 156 RLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAAS 215 D + A+ + +++ A+ A G +AI + A Sbjct: 90 -------------DVSGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIQSYRTAL 136 Query: 216 KLKNDNTEAFYKIS 229 KLK D +A+ ++ Sbjct: 137 KLKPDFPDAYCNLA 150 >4KYI-A nrPDB Length = 551 Score = 29.3 bits (64), Expect = 4.4, Method: Compositional matrix adjust. Identities = 19/73 (26%), Positives = 35/73 (47%), Gaps = 3/73 (4%) Query: 124 AEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEV 183 D K L SE E EA + + + L+ Q + GDY++ +LD+I ++ Sbjct: 411 GHDKLKDALIDEKSEKEIFEASAH---AQAILHLQEQIVKEMNDGDYSSVQNYLDQIEDI 467 Query: 184 CVWDAELRELRAE 196 DA++ +++ E Sbjct: 468 LTVDAKMDDIQKE 480 >1YKW-A nrPDB Length = 435 Score = 29.3 bits (64), Expect = 4.6, Method: Compositional matrix adjust. Identities = 18/55 (32%), Positives = 30/55 (54%), Gaps = 4/55 (7%) Query: 348 EAYLIEEMYDEAIQDYETAQEHNENDQQI----REGLEKAQRLLKQSQKRDYYKI 398 E YL+ + Y E++ D ETA H ++Q R G+++ RL+ ++ DY I Sbjct: 19 EQYLVLDYYLESVGDIETALAHFCSEQSTAQWKRVGVDEDFRLVHAAKVIDYEVI 73 >5LDX-e nrPDB Length = 106 Score = 29.3 bits (64), Expect = 4.7, Method: Compositional matrix adjust. Identities = 14/45 (31%), Positives = 26/45 (57%) Query: 241 SLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYT 285 S+ +EC +D + C K +K+L+ + E+LI++G+YT Sbjct: 49 SIRAEKECKIEFEDFRECLLRQKTMKRLHAIRRQREKLIKEGKYT 93 >6FYY-p nrPDB Length = 763 Score = 28.9 bits (63), Expect = 4.8, Method: Compositional matrix adjust. Identities = 15/52 (28%), Positives = 26/52 (50%) Query: 396 YKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKE 447 YKI + N K++II ++ A + P + + E+KK K + +A E Sbjct: 637 YKIFNIAGNLVKEDIIAGFKNFAWRPRPASILSNAERKKVRKNLREWSAQFE 688 >3LL3-A nrPDB Length = 504 Score = 28.9 bits (63), Expect = 5.9, Method: Compositional matrix adjust. Identities = 33/133 (24%), Positives = 55/133 (41%), Gaps = 25/133 (18%) Query: 106 AARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRL-------- 157 A + +G+ L+ Q K+ +AE+D K + + Q I D Q++ Sbjct: 28 VASVSKGYPLI-QTKVGQAEEDPKLIFDA-----------VQEIIFDLTQKIDGKIAAIS 75 Query: 158 ---RSQALNAFGSGD--YTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLK 212 + +L GS D T +I + D + V DA+ R + + K G P ++ + Sbjct: 76 WSSQMHSLIGLGSDDELLTNSITWADNCAKSIVQDAKNRGFAQQIYRKTGMPMHPMAPIY 135 Query: 213 AASKLKNDNTEAF 225 LKN TE F Sbjct: 136 KLLWLKNKKTEVF 148 >5WM0-A nrPDB Length = 976 Score = 28.5 bits (62), Expect = 7.3, Method: Compositional matrix adjust. Identities = 20/73 (27%), Positives = 33/73 (45%), Gaps = 3/73 (4%) Query: 71 YIAYYRRATVFLA-MGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFK 129 YI YY A L+ M +K PD+ + I + + + +++ G EAE+ K Sbjct: 318 YIMYYMEAKYALSFMTCTKNVAPDMFRTIPAEANIPIP--VKPDMVMMHGHHKEAENKEK 375 Query: 130 KVLKSNPSENEEK 142 L P + EE+ Sbjct: 376 SALMQQPKQGEEE 388 >4IT5-A nrPDB Length = 174 Score = 28.1 bits (61), Expect = 9.3, Method: Compositional matrix adjust. Identities = 18/73 (24%), Positives = 35/73 (47%), Gaps = 4/73 (5%) Query: 390 SQKRDYYKILG--VKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKK--AEKKFIDIAAA 445 S +Y+++ G ++ + +R L ++HPDNF E+ + A ++ I A Sbjct: 1 SNAMNYFELFGLPIQFELDGSLLSSQFRALQKRFHPDNFATASERDRLMAVQQAAQINDA 60 Query: 446 KEVLSDPEMRKKF 458 + L DP R ++ Sbjct: 61 YQTLKDPLRRAEY 73 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2Y4T-A nrPDB 647 0.0 6FO1-G nrPDB 308 3e-84 1W3B-A nrPDB 169 3e-42 5AYL-A nrPDB 124 8e-29 3APQ-A nrPDB 119 3e-27 6N3Q-D nrPDB 117 1e-26 1IHG-A nrPDB 114 1e-25 4J80-A nrPDB 104 1e-22 2L6L-A nrPDB 99 3e-21 4WB7-A nrPDB 95 7e-20 3LZ8-A nrPDB 92 4e-19 Sequences not found previously or not previously below threshold: 5JJT-A nrPDB 84 1e-16 4JA9-A nrPDB 81 1e-15 5LVV-A nrPDB 78 1e-14 5A01-A nrPDB 75 6e-14 6B85-J nrPDB 71 9e-13 1A17-A nrPDB 71 1e-12 5G04-F nrPDB 71 1e-12 2GW1-A nrPDB 68 7e-12 4I2W-A nrPDB 65 6e-11 1QZ2-A nrPDB 62 6e-10 5OMP-A nrPDB 61 1e-09 1KT1-A nrPDB 60 3e-09 2C2L-A nrPDB 59 5e-09 5MGX-E nrPDB 53 3e-07 4CGU-A nrPDB 52 5e-07 5FZQ-A nrPDB 51 9e-07 5ZYQ-A nrPDB 51 9e-07 5JHE-A nrPDB 51 1e-06 2IF4-A nrPDB 51 1e-06 5Y88-T nrPDB 49 4e-06 4ZLH-A nrPDB 49 5e-06 5WQL-B nrPDB 47 1e-05 5DSE-A nrPDB 46 3e-05 5G04-X nrPDB 46 3e-05 1FPO-A nrPDB 44 1e-04 4IT5-A nrPDB 44 2e-04 4HOQ-A nrPDB 41 0.001 6AF0-A nrPDB 40 0.002 5G05-C nrPDB 40 0.003 5NNP-A nrPDB 40 0.003 6C95-A nrPDB 39 0.003 4UZY-A nrPDB 39 0.004 5KHR-J nrPDB 39 0.007 5JZ6-A nrPDB 38 0.010 3I5P-A nrPDB 37 0.013 2WZV-A nrPDB 37 0.020 3UO2-A nrPDB 37 0.020 4JHR-A nrPDB 36 0.030 4F3X-A nrPDB 36 0.035 6G70-A nrPDB 36 0.058 5WRW-A nrPDB 35 0.065 3HVU-A nrPDB 35 0.071 5OJF-A nrPDB 35 0.083 2PF4-E nrPDB 35 0.093 4GYO-A nrPDB 35 0.11 3N2B-A nrPDB 34 0.14 6FRK-r nrPDB 34 0.14 5EFR-A nrPDB 34 0.15 5OJ8-A nrPDB 34 0.17 5UDI-A nrPDB 34 0.19 4PFR-A nrPDB 34 0.23 3QDN-A nrPDB 33 0.24 3NF1-A nrPDB 33 0.26 3BVO-A nrPDB 33 0.26 6CNF-R nrPDB 33 0.28 1HH8-A nrPDB 33 0.30 5AEM-A nrPDB 33 0.38 4Q0N-A nrPDB 33 0.38 3ZFW-A nrPDB 32 0.45 1F6F-A nrPDB 32 0.47 6F41-V nrPDB 32 0.52 4E69-A nrPDB 32 0.53 3LM0-A nrPDB 32 0.55 2DB3-A nrPDB 32 0.55 2C7S-A nrPDB 32 0.60 4JOS-A nrPDB 32 0.64 3UHP-A nrPDB 32 0.66 4HOU-A nrPDB 32 0.70 2JIS-A nrPDB 32 0.81 1XMD-A nrPDB 31 0.93 5B8H-A nrPDB 31 0.99 3J98-H nrPDB 31 1.2 4HY3-A nrPDB 31 1.5 5CM6-A nrPDB 30 1.7 2RKQ-A nrPDB 30 1.8 2OMK-A nrPDB 30 2.3 4JB7-A nrPDB 30 2.4 2J90-A nrPDB 30 2.4 5J0A-A nrPDB 30 2.9 5LN3-Z nrPDB 29 3.7 3QOU-A nrPDB 29 3.8 3J3U-A nrPDB 29 4.2 4G1T-A nrPDB 29 4.4 3PXI-A nrPDB 29 4.7 5XJC-J nrPDB 29 5.2 3PXG-A nrPDB 29 5.3 5ZYP-A nrPDB 28 8.9 3ZQ6-A nrPDB 28 9.4 >2Y4T-A nrPDB Length = 450 Score = 647 bits (1670), Expect = 0.0, Method: Composition-based stats. Identities = 431/440 (97%), Positives = 431/440 (97%) Query: 22 VDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVF 81 VDL E ADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVF Sbjct: 11 VDLGTENLYFQSMADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVF 70 Query: 82 LAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEE 141 LAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEE Sbjct: 71 LAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEE 130 Query: 142 KEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKE 201 KEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKE Sbjct: 131 KEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKE 190 Query: 202 GEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAH 261 GEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAH Sbjct: 191 GEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAH 250 Query: 262 YKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEK 321 YKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEK Sbjct: 251 YKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEK 310 Query: 322 PVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLE 381 PVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLE Sbjct: 311 PVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLE 370 Query: 382 KAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFID 441 KAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFID Sbjct: 371 KAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFID 430 Query: 442 IAAAKEVLSDPEMRKKFDDG 461 IAAAKEVLSDPEMRKKFDDG Sbjct: 431 IAAAKEVLSDPEMRKKFDDG 450 >6FO1-G nrPDB Length = 665 Score = 308 bits (789), Expect = 3e-84, Method: Composition-based stats. Identities = 69/291 (23%), Positives = 115/291 (39%), Gaps = 44/291 (15%) Query: 32 GVNADVEKHLEL---GKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSK 88 G++ D +K L L G K G+ +A+ + +D DP N + RA+ + + K Sbjct: 125 GIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFA 184 Query: 89 AALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPS----------- 137 A D + L +T A +RG KL+EA+ D+++VL+ P+ Sbjct: 185 VAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKI 244 Query: 138 -------ENEEKEAQSQLIKSDEMQRL-------RSQALNA-------FGSGDYTAAIAF 176 EN + +IKS E +R + QA++ F G Y AI Sbjct: 245 SQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIEC 304 Query: 177 LDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLG 236 + + +A L RA ++K + +A D A L ++AF + T LG Sbjct: 305 YTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLG 364 Query: 237 DHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDA 287 + + L L+ +K+ ++KK ELI G + D Sbjct: 365 KLNEAKQDFETVLLLEPGNKQAVTELSKIKK---------ELIEKGHWDDV 406 Score = 108 bits (270), Expect = 5e-24, Method: Composition-based stats. Identities = 48/270 (17%), Positives = 98/270 (36%), Gaps = 31/270 (11%) Query: 149 IKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAI 208 + S + L+ + F G Y AI K ++ ++ L RA + + + A Sbjct: 128 VDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAE 187 Query: 209 SDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQV--- 265 SD A L T+A+ + + L E + + L+L+ ++ +++ Sbjct: 188 SDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQA 247 Query: 266 --KKLNKLIESAEELI-----RDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFS- 317 K N + A+ +I + +K +++ + + + ER C++ Sbjct: 248 LASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTR 307 Query: 318 --------------------KDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYD 357 K +K EA + C++ + ++ A R A + Sbjct: 308 GIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLN 367 Query: 358 EAIQDYETAQEHNENDQQIREGLEKAQRLL 387 EA QD+ET ++Q L K ++ L Sbjct: 368 EAKQDFETVLLLEPGNKQAVTELSKIKKEL 397 >1W3B-A nrPDB Length = 388 Score = 169 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 61/300 (20%), Positives = 112/300 (37%), Gaps = 24/300 (8%) Query: 37 VEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTK 96 E + LG GQL +A+ + A+ PD Y A +A G + A+ Sbjct: 67 AEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVS 126 Query: 97 VIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPS-----------ENEEKEAQ 145 +Q D R G+LL G+L+EA+ + K +++ P+ N + E Sbjct: 127 ALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIW 186 Query: 146 SQLIKSDEMQRLRSQALNAF-------GSGD-YTAAIAFLDKILEVCVWDAELRELRAEC 197 + ++ L L+A+ + A+A + L + A + A Sbjct: 187 LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACV 246 Query: 198 FIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKR 257 + ++G AI + A +L+ +A+ ++ + G + L+L H Sbjct: 247 YYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHAD 306 Query: 258 CFAHYKQVKKLNKLIESAEELIRDG-----RYTDATSKYESVMKTEPSIAEYTVRSKERI 312 + +K+ IE A L R + A S SV++ + + E + KE I Sbjct: 307 SLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAI 366 Score = 82.1 bits (201), Expect = 5e-16, Method: Composition-based stats. Identities = 40/229 (17%), Positives = 82/229 (35%), Gaps = 15/229 (6%) Query: 39 KHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVI 98 LG A G++ A+ F AV DP+ AY V A+ + + Sbjct: 171 AWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRAL 230 Query: 99 QLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLR 158 L + + +QG +D A D +++ ++ P +A L Sbjct: 231 SLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPH---FPDAYCNL---------- 277 Query: 159 SQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLK 218 + AL G A + L +C A+ A ++G +A+ + A ++ Sbjct: 278 ANALKE--KGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVF 335 Query: 219 NDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKK 267 + A ++++ Q G + +L +E +++ +++ K Sbjct: 336 PEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLK 384 Score = 79.4 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 39/200 (19%), Positives = 79/200 (39%), Gaps = 15/200 (7%) Query: 38 EKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKV 97 + ++ LG L A A++ + A+ P++ + + A V+ G A+ + Sbjct: 204 DAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRA 263 Query: 98 IQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRL 157 I+L+ F A + L ++G + EAED + L+ P+ L ++R Sbjct: 264 IELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTH------ADSLNNLANIKR- 316 Query: 158 RSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKL 217 G+ A+ K LEV A A ++G+ ++A+ K A ++ Sbjct: 317 --------EQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRI 368 Query: 218 KNDNTEAFYKISTLYYQLGD 237 +A+ + ++ D Sbjct: 369 SPTFADAYSNMGNTLKEMQD 388 Score = 32.4 bits (72), Expect = 0.52, Method: Composition-based stats. Identities = 30/162 (18%), Positives = 64/162 (39%), Gaps = 19/162 (11%) Query: 233 YQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYE 292 YQ GD E + + + + D+ + L R ++ Sbjct: 10 YQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIH------FQCRRLDRSAHFSTLA---- 59 Query: 293 SVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLI 352 +K P +AE + + + + + + EAI L+++PD ++ + A A + Sbjct: 60 --IKQNPLLAE----AYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVA 113 Query: 353 EEMYDEAIQDYETAQEHNENDQQIREG---LEKAQRLLKQSQ 391 + A+Q Y +A ++N + +R L KA L++++ Sbjct: 114 AGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAK 155 >5AYL-A nrPDB Length = 783 Score = 124 bits (312), Expect = 8e-29, Method: Composition-based stats. Identities = 34/97 (35%), Positives = 53/97 (54%), Gaps = 8/97 (8%) Query: 390 SQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVL 449 +++Y +LGV + A +EI +A++KLAL+ HPD N A F+ I A EVL Sbjct: 21 MTDQNFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPN---NPNAHGDFLKINRAYEVL 77 Query: 450 SDPEMRKKFDDGEDPLDAESQQGGGGNPFHRSWNSWQ 486 D ++RKK+D + E QGG + SW+ ++ Sbjct: 78 KDEDLRKKYDKYGEK-GLEDNQGGQ----YESWSYYR 109 >3APQ-A nrPDB Length = 210 Score = 119 bits (298), Expect = 3e-27, Method: Composition-based stats. Identities = 34/94 (36%), Positives = 53/94 (56%), Gaps = 8/94 (8%) Query: 393 RDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDP 452 +++Y +LGV + A +EI +A++KLAL+ HPD N A F+ I A EVL D Sbjct: 2 QNFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPN---NPNAHGDFLKINRAYEVLKDE 58 Query: 453 EMRKKFDDGEDPLDAESQQGGGGNPFHRSWNSWQ 486 ++RKK+D + E QGG + SW+ ++ Sbjct: 59 DLRKKYDKYGEK-GLEDNQGGQ----YESWSYYR 87 >6N3Q-D nrPDB Length = 663 Score = 117 bits (293), Expect = 1e-26, Method: Composition-based stats. Identities = 28/89 (31%), Positives = 46/89 (51%), Gaps = 3/89 (3%) Query: 394 DYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQ---NEEEKKKAEKKFIDIAAAKEVLS 450 D Y+ILG+ +A ++I AYRKL++++HPD +EK E+ ++ I A E L+ Sbjct: 125 DPYEILGISTSASDRDIKSAYRKLSVKFHPDKLAKGLTPDEKSVMEETYVQITKAYESLT 184 Query: 451 DPEMRKKFDDGEDPLDAESQQGGGGNPFH 479 D +R+ + P +S G P Sbjct: 185 DELVRQNYLKYGHPDGPQSTSHGIALPRF 213 >1IHG-A nrPDB Length = 370 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 36/158 (22%), Positives = 72/158 (45%), Gaps = 4/158 (2%) Query: 237 DHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMK 296 D ++ L +V + L + +D K + + + I+ +++R + A ++ K Sbjct: 208 DADVDLKDVDKILLISEDLKNIGNTFFKSQNWEMAIKKYTKVLRYVEGSRAAAEDADGAK 267 Query: 297 TEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMY 356 +P + I C K A+ C E L+++P N AL RA+ + + Y Sbjct: 268 LQPVALSCVLN----IGACKLKMSDWQGAVDSCLEALEIDPSNTKALYRRAQGWQGLKEY 323 Query: 357 DEAIQDYETAQEHNENDQQIREGLEKAQRLLKQSQKRD 394 D+A+ D + AQE D+ I+ L K ++ +K + ++ Sbjct: 324 DQALADLKKAQEIAPEDKAIQAELLKVKQKIKAQKDKE 361 Score = 50.5 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 27/162 (16%), Positives = 64/162 (39%), Gaps = 21/162 (12%) Query: 137 SENEEKEAQSQLIKSDE-----MQRLRSQALNAFGSGDYTAAIAFLDKIL---------- 181 S + E +K + + L++ F S ++ AI K+L Sbjct: 201 SHPDFPEDADVDLKDVDKILLISEDLKNIGNTFFKSQNWEMAIKKYTKVLRYVEGSRAAA 260 Query: 182 -EVCVWDAELRELR-----AECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQL 235 + + L C +K + + A+ A ++ NT+A Y+ + + L Sbjct: 261 EDADGAKLQPVALSCVLNIGACKLKMSDWQGAVDSCLEALEIDPSNTKALYRRAQGWQGL 320 Query: 236 GDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEE 277 +++ +L+++++ ++ + K A +VK+ K + E+ Sbjct: 321 KEYDQALADLKKAQEIAPEDKAIQAELLKVKQKIKAQKDKEK 362 Score = 39.0 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 25/91 (27%), Positives = 42/91 (46%), Gaps = 4/91 (4%) Query: 41 LELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQL 100 L +G L A+ A++ DP N A YRRA + + + AL DL K ++ Sbjct: 277 LNIGACKLKMSDWQGAVDSCLEALEIDPSNTKALYRRAQGWQGLKEYDQALADLKKAQEI 336 Query: 101 KMDFTAARLQRGHLLLKQGKLDEAEDDFKKV 131 + A + + LL + K+ +A+ D +K Sbjct: 337 APEDKAIQAE---LLKVKQKI-KAQKDKEKA 363 >4J80-A nrPDB Length = 284 Score = 104 bits (258), Expect = 1e-22, Method: Composition-based stats. Identities = 37/85 (43%), Positives = 52/85 (61%), Gaps = 4/85 (4%) Query: 390 SQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVL 449 + K+DYY ILGV RNA ++EI +AY++LA Q+HPD ++ E AE+KF +I A V+ Sbjct: 2 AAKKDYYAILGVPRNATQEEIKRAYKRLARQYHPDVNKSPE----AEEKFKEINEAYAVM 57 Query: 450 SDPEMRKKFDDGEDPLDAESQQGGG 474 SDPE R+ +D GG Sbjct: 58 SDPEKRRIYDTYGTTEAPPPPPPGG 82 >2L6L-A nrPDB Length = 155 Score = 99.4 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 24/76 (31%), Positives = 44/76 (57%), Gaps = 3/76 (3%) Query: 387 LKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEK---KFIDIA 443 ++Q K+D+Y ILG +A ++ + Y+KL L +HPD + E+ KFI+I Sbjct: 4 VEQMPKKDWYSILGADPSANISDLKQKYQKLILMYHPDKQSTDVPAGTVEECVQKFIEID 63 Query: 444 AAKEVLSDPEMRKKFD 459 A ++L + E ++++D Sbjct: 64 QAWKILGNEETKREYD 79 >4WB7-A nrPDB Length = 405 Score = 95.2 bits (235), Expect = 7e-20, Method: Composition-based stats. Identities = 32/71 (45%), Positives = 47/71 (66%), Gaps = 4/71 (5%) Query: 393 RDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDP 452 +DYY+ LG+ R A +EI +AYR+ AL++HPD + + AE+KF +IA A +VLSDP Sbjct: 2 KDYYQTLGLARGASDEEIKRAYRRQALRYHPDKNK----EPGAEEKFKEIAEAYDVLSDP 57 Query: 453 EMRKKFDDGED 463 R+ FD + Sbjct: 58 RKREIFDRYGE 68 >3LZ8-A nrPDB Length = 329 Score = 92.1 bits (227), Expect = 4e-19, Method: Composition-based stats. Identities = 29/72 (40%), Positives = 42/72 (58%), Gaps = 4/72 (5%) Query: 389 QSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEV 448 + +DYY ILGV+ + I AYR+LA ++HPD ++ AE KF D+A A EV Sbjct: 24 AMELKDYYAILGVQPTDDLKTIKTAYRRLARKYHPD----VSKENDAEAKFKDLAEAWEV 79 Query: 449 LSDPEMRKKFDD 460 L D + R ++D Sbjct: 80 LKDEQRRAEYDQ 91 >5JJT-A nrPDB Length = 479 Score = 84.0 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 27/127 (21%), Positives = 54/127 (42%) Query: 152 DEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDL 211 + +SQA AF Y++AI K +E+ +A RA K E AI D Sbjct: 7 SRAEEFKSQANEAFKGHKYSSAIDLYTKAIELNSNNAVYWANRAFAHTKLEEYGSAIQDA 66 Query: 212 KAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKL 271 A ++ + ++ +Y+ Y +G + +L + ++ +L + K+ +K Sbjct: 67 SKAIEVDSRYSKGYYRRGAAYLAMGKFKDALKDFQQVKRLSPNDPDATRKLKECEKAVMK 126 Query: 272 IESAEEL 278 ++ E + Sbjct: 127 LKFEEAI 133 Score = 68.6 bits (166), Expect = 6e-12, Method: Composition-based stats. Identities = 23/108 (21%), Positives = 53/108 (49%), Gaps = 3/108 (2%) Query: 34 NADVEKHLEL---GKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAA 90 N+DV + E + + + A+ + A++ + +N + + RA + + +A Sbjct: 3 NSDVSRAEEFKSQANEAFKGHKYSSAIDLYTKAIELNSNNAVYWANRAFAHTKLEEYGSA 62 Query: 91 LPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSE 138 + D +K I++ ++ +RG L GK +A DF++V + +P++ Sbjct: 63 IQDASKAIEVDSRYSKGYYRRGAAYLAMGKFKDALKDFQQVKRLSPND 110 Score = 44.0 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 23/138 (16%), Positives = 57/138 (41%), Gaps = 4/138 (2%) Query: 261 HYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDE 320 V + + A E + +Y+ A Y ++ + A Y + H +K E Sbjct: 2 ENSDVSRAEEFKSQANEAFKGHKYSSAIDLYTKAIELNSNNAVYW--ANRAFAH--TKLE 57 Query: 321 KPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGL 380 + AI+ S+ ++++ R AYL + +A++D++ + + ND L Sbjct: 58 EYGSAIQDASKAIEVDSRYSKGYYRRGAAYLAMGKFKDALKDFQQVKRLSPNDPDATRKL 117 Query: 381 EKAQRLLKQSQKRDYYKI 398 ++ ++ + + + + + Sbjct: 118 KECEKAVMKLKFEEAISV 135 >4JA9-A nrPDB Length = 488 Score = 80.6 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 30/144 (20%), Positives = 62/144 (43%), Gaps = 3/144 (2%) Query: 140 EEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFI 199 +E A+ L +++E L++QA + F + DY AI F + +E+ +A R+ ++ Sbjct: 6 DEPPAEGTLKRAEE---LKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYL 62 Query: 200 KEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCF 259 + A+ D A +L + +Y+ + LG +L + +K+ + K Sbjct: 63 RTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPNDKDAK 122 Query: 260 AHYKQVKKLNKLIESAEELIRDGR 283 Y++ K+ K + D Sbjct: 123 MKYQECSKIVKQKAFERAIAGDEH 146 Score = 72.1 bits (175), Expect = 5e-13, Method: Composition-based stats. Identities = 29/128 (22%), Positives = 54/128 (42%), Gaps = 3/128 (2%) Query: 32 GVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAAL 91 G E+ A +A+ + A++ +P N I Y R+ +L AL Sbjct: 12 GTLKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYAL 71 Query: 92 PDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEK---EAQSQL 148 D T+ I+L + +R + GK A D++ V+K P++ + K + S++ Sbjct: 72 GDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPNDKDAKMKYQECSKI 131 Query: 149 IKSDEMQR 156 +K +R Sbjct: 132 VKQKAFER 139 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 25/129 (19%), Positives = 55/129 (42%), Gaps = 8/129 (6%) Query: 265 VKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIA-EYTVRSKERI-CHCFSKDEKP 322 +K+ +L A + + Y +A Y ++ PS A Y RS + C+ Sbjct: 14 LKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGY---- 69 Query: 323 VEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEK 382 A+ + ++++ + RA + + + A++DYET + ND+ + ++ Sbjct: 70 --ALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPNDKDAKMKYQE 127 Query: 383 AQRLLKQSQ 391 +++KQ Sbjct: 128 CSKIVKQKA 136 >5LVV-A nrPDB Length = 749 Score = 77.9 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 25/99 (25%), Positives = 36/99 (36%) Query: 39 KHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVI 98 H L L G+L +AL + A+ P AY M + AL T+ I Sbjct: 66 AHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAI 125 Query: 99 QLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPS 137 Q+ F A + G + EA ++ LK P Sbjct: 126 QINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 164 Score = 72.5 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 23/105 (21%), Positives = 44/105 (41%), Gaps = 2/105 (1%) Query: 32 GVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAAL 91 G +AD L G + +A+ + A++ P+ A+ A+V GK + AL Sbjct: 27 GTHADSLN--NLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEAL 84 Query: 92 PDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNP 136 + I++ F A G+ L + + A + + ++ NP Sbjct: 85 MHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINP 129 Score = 57.5 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 33/150 (22%), Positives = 61/150 (40%), Gaps = 15/150 (10%) Query: 76 RRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSN 135 A + G + A+ K +++ +F AA +L +QGKL EA +K+ ++ + Sbjct: 35 NLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRIS 94 Query: 136 PSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRA 195 P+ + +K EMQ D A+ + +++ A+ A Sbjct: 95 PTFADAYSNMGNTLK--EMQ-------------DVQGALQCYTRAIQINPAFADAHSNLA 139 Query: 196 ECFIKEGEPRKAISDLKAASKLKNDNTEAF 225 G +AI+ + A KLK D +A+ Sbjct: 140 SIHKDSGNIPEAIASYRTALKLKPDFPDAY 169 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 17/79 (21%), Positives = 30/79 (37%) Query: 37 VEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTK 96 + + +G L + AL + A+ +P A+ A++ G A+ Sbjct: 98 ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT 157 Query: 97 VIQLKMDFTAARLQRGHLL 115 ++LK DF A H L Sbjct: 158 ALKLKPDFPDAYCNLAHCL 176 Score = 33.6 bits (75), Expect = 0.24, Method: Composition-based stats. Identities = 28/173 (16%), Positives = 65/173 (37%), Gaps = 21/173 (12%) Query: 204 PRKAISDLKAASKLK---NDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFA 260 A S K + L + ++ ++ + + G+ E ++ R+ L++ + + Sbjct: 9 YSSAQSTSKTSVTLSLGGGTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHS 68 Query: 261 HYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDE 320 + V L + G+ +A Y+ ++ P+ A+ + K+ Sbjct: 69 NLASV------------LQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTL-----KEM 111 Query: 321 KPVEAIRVC-SEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNEN 372 + V+ C + +Q+ P +A + A + EAI Y TA + + Sbjct: 112 QDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 164 Score = 33.2 bits (74), Expect = 0.29, Method: Composition-based stats. Identities = 29/168 (17%), Positives = 66/168 (39%), Gaps = 21/168 (12%) Query: 200 KEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCF 259 ++G +A+ + A ++ + A ++++ Q G + +L +E +++ + Sbjct: 42 EQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAY 101 Query: 260 AHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKD 319 ++ K + ++ A + Y ++ P+ A+ S H KD Sbjct: 102 SNMGNTLKEMQDVQGALQC------------YTRAIQINPAFAD--AHSNLASIH---KD 144 Query: 320 EKPV-EAIRVCSEVLQMEPDNVNALKDRAEAYLIE---EMYDEAIQDY 363 + EAI L+++PD +A + A I YDE ++ Sbjct: 145 SGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKL 192 >5A01-A nrPDB Length = 710 Score = 75.2 bits (183), Expect = 6e-14, Method: Composition-based stats. Identities = 24/99 (24%), Positives = 35/99 (35%) Query: 39 KHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVI 98 H L L G+L +AL + A+ P AY + AL T+ I Sbjct: 43 AHSNLASVLQQQGKLKEALMHYKEAIRIQPTFADAYSNMGNTLKELQDVSGALQCYTRAI 102 Query: 99 QLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPS 137 Q+ F A + G + EA ++ LK P Sbjct: 103 QINPAFADAHSNLASIHKDSGNIPEAIQSYRTALKLKPD 141 Score = 71.3 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 25/106 (23%), Positives = 44/106 (41%), Gaps = 2/106 (1%) Query: 31 CGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAA 90 C +AD L G + +A + A++ PD A+ A+V GK K A Sbjct: 3 CSNHADSLN--NLANIKREQGYIEEATRLYLKALEVFPDFAAAHSNLASVLQQQGKLKEA 60 Query: 91 LPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNP 136 L + I+++ F A G+ L + + A + + ++ NP Sbjct: 61 LMHYKEAIRIQPTFADAYSNMGNTLKELQDVSGALQCYTRAIQINP 106 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 33/150 (22%), Positives = 59/150 (39%), Gaps = 15/150 (10%) Query: 76 RRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSN 135 A + G + A K +++ DF AA +L +QGKL EA +K+ ++ Sbjct: 12 NLANIKREQGYIEEATRLYLKALEVFPDFAAAHSNLASVLQQQGKLKEALMHYKEAIRIQ 71 Query: 136 PSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRA 195 P+ + +K E+Q D + A+ + +++ A+ A Sbjct: 72 PTFADAYSNMGNTLK--ELQ-------------DVSGALQCYTRAIQINPAFADAHSNLA 116 Query: 196 ECFIKEGEPRKAISDLKAASKLKNDNTEAF 225 G +AI + A KLK D +A+ Sbjct: 117 SIHKDSGNIPEAIQSYRTALKLKPDFPDAY 146 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 17/79 (21%), Positives = 31/79 (39%) Query: 37 VEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTK 96 + + +G L ++ AL + A+ +P A+ A++ G A+ Sbjct: 75 ADAYSNMGNTLKELQDVSGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIQSYRT 134 Query: 97 VIQLKMDFTAARLQRGHLL 115 ++LK DF A H L Sbjct: 135 ALKLKPDFPDAYCNLAHCL 153 Score = 30.5 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 26/145 (17%), Positives = 47/145 (32%), Gaps = 22/145 (15%) Query: 280 RDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDN 339 G +AT Y ++ P A + + + K EA+ E ++++P Sbjct: 19 EQGYIEEATRLYLKALEVFPDFAA----AHSNLASVLQQQGKLKEALMHYKEAIRIQPTF 74 Query: 340 VNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLLKQSQKRDYYKIL 399 +A + + A+Q Y A + N L + Sbjct: 75 ADAYSNMGNTLKELQDVSGALQCYTRAIQINPAFADAHSNLASIHK-------------- 120 Query: 400 GVKRNAKKQEIIKAYRKLALQWHPD 424 + E I++YR AL+ PD Sbjct: 121 ---DSGNIPEAIQSYRT-ALKLKPD 141 Score = 30.1 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 27/154 (17%), Positives = 59/154 (38%), Gaps = 18/154 (11%) Query: 200 KEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCF 259 ++G +A A ++ D A ++++ Q G + +L +E +++ + Sbjct: 19 EQGYIEEATRLYLKALEVFPDFAAAHSNLASVLQQQGKLKEALMHYKEAIRIQPTFADAY 78 Query: 260 AHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKD 319 ++ K + + A + Y ++ P+ A+ S H KD Sbjct: 79 SNMGNTLKELQDVSGALQC------------YTRAIQINPAFAD--AHSNLASIH---KD 121 Query: 320 EKPV-EAIRVCSEVLQMEPDNVNALKDRAEAYLI 352 + EAI+ L+++PD +A + A I Sbjct: 122 SGNIPEAIQSYRTALKLKPDFPDAYCNLAHCLQI 155 >6B85-J nrPDB Length = 223 Score = 71.3 bits (173), Expect = 9e-13, Method: Composition-based stats. Identities = 29/106 (27%), Positives = 51/106 (48%) Query: 36 DVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLT 95 D L LG L +L +A + A++ P++ A+ V +G+ A Sbjct: 114 DALAWLLLGSVLEKLKRLDEAAEAYKKAIELKPNDASAWKELGKVLEKLGRLDEAAEAYK 173 Query: 96 KVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEE 141 K I+L + A + G +L K G+LDEA + +KK ++ +P++ E Sbjct: 174 KAIELDPEDAEAWKELGKVLEKLGRLDEAAEAYKKAIELDPNDLEH 219 Score = 64.0 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 39/174 (22%), Positives = 76/174 (43%), Gaps = 17/174 (9%) Query: 18 LLVLVDLQYEGAECGVNADVEK--HLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYY 75 + +L+ Q E + DV ++ LG L +L+ A + A++ DP++ +A+ Sbjct: 60 IALLLSRQTEQVAESIRRDVSALAYVMLGLLLSLLNRLSLAAEAYKKAIELDPNDALAWL 119 Query: 76 RRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSN 135 +V + + A K I+LK + +A + G +L K G+LDEA + +KK ++ + Sbjct: 120 LLGSVLEKLKRLDEAAEAYKKAIELKPNDASAWKELGKVLEKLGRLDEAAEAYKKAIELD 179 Query: 136 PSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAE 189 P + E + ++++ G A K +E+ D E Sbjct: 180 PEDAEAWKELGKVLE---------------KLGRLDEAAEAYKKAIELDPNDLE 218 Score = 45.9 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 25/132 (18%), Positives = 53/132 (40%), Gaps = 12/132 (9%) Query: 173 AIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLY 232 A K +E+ DA L K +A K A +LK ++ A+ ++ + Sbjct: 100 AAEAYKKAIELDPNDALAWLLLGSVLEKLKRLDEAAEAYKKAIELKPNDASAWKELGKVL 159 Query: 233 YQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYE 292 +LG + + ++ ++LD + + +V L + GR +A Y+ Sbjct: 160 EKLGRLDEAAEAYKKAIELDPEDAEAWKELGKV------------LEKLGRLDEAAEAYK 207 Query: 293 SVMKTEPSIAEY 304 ++ +P+ E+ Sbjct: 208 KAIELDPNDLEH 219 Score = 36.3 bits (82), Expect = 0.030, Method: Composition-based stats. Identities = 25/126 (19%), Positives = 47/126 (37%), Gaps = 18/126 (14%) Query: 325 AIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQ 384 A + ++++P++ A + DEA + Y+ A E ND + L K Sbjct: 100 AAEAYKKAIELDPNDALAWLLLGSVLEKLKRLDEAAEAYKKAIELKPNDASAWKELGKVL 159 Query: 385 RLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAA 444 L + E +AY+K A++ P++ + +E K +K + Sbjct: 160 EKL-----------------GRLDEAAEAYKK-AIELDPEDAEAWKELGKVLEKLGRLDE 201 Query: 445 AKEVLS 450 A E Sbjct: 202 AAEAYK 207 Score = 36.3 bits (82), Expect = 0.036, Method: Composition-based stats. Identities = 15/64 (23%), Positives = 30/64 (46%) Query: 324 EAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKA 383 EA + ++++P++ +A K+ + DEA + Y+ A E + D + + L K Sbjct: 133 EAAEAYKKAIELKPNDASAWKELGKVLEKLGRLDEAAEAYKKAIELDPEDAEAWKELGKV 192 Query: 384 QRLL 387 L Sbjct: 193 LEKL 196 Score = 35.1 bits (79), Expect = 0.067, Method: Composition-based stats. Identities = 19/91 (20%), Positives = 41/91 (45%), Gaps = 4/91 (4%) Query: 283 RYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNA 342 R +A Y+ ++ +P+ A + + + K + EA + ++++P++ A Sbjct: 130 RLDEAAEAYKKAIELKPNDAS----AWKELGKVLEKLGRLDEAAEAYKKAIELDPEDAEA 185 Query: 343 LKDRAEAYLIEEMYDEAIQDYETAQEHNEND 373 K+ + DEA + Y+ A E + ND Sbjct: 186 WKELGKVLEKLGRLDEAAEAYKKAIELDPND 216 >1A17-A nrPDB Length = 166 Score = 70.9 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 26/129 (20%), Positives = 53/129 (41%) Query: 155 QRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAA 214 + L++QA + F + DY AI F + +E+ +A R+ +++ A+ D A Sbjct: 14 EELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALGDATRA 73 Query: 215 SKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIES 274 +L + +Y+ + LG +L + +K+ K Y++ K+ K Sbjct: 74 IELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQECNKIVKQKAF 133 Query: 275 AEELIRDGR 283 + D Sbjct: 134 ERAIAGDEH 142 Score = 62.1 bits (149), Expect = 5e-10, Method: Composition-based stats. Identities = 28/128 (21%), Positives = 53/128 (41%), Gaps = 3/128 (2%) Query: 32 GVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAAL 91 G E+ A +A+ + A++ +P N I Y R+ +L AL Sbjct: 8 GALKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYAL 67 Query: 92 PDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEK---EAQSQL 148 D T+ I+L + +R + GK A D++ V+K P + + K + +++ Sbjct: 68 GDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQECNKI 127 Query: 149 IKSDEMQR 156 +K +R Sbjct: 128 VKQKAFER 135 Score = 37.4 bits (85), Expect = 0.017, Method: Composition-based stats. Identities = 22/127 (17%), Positives = 53/127 (41%), Gaps = 4/127 (3%) Query: 265 VKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVE 324 +K+ +L A + + Y +A Y ++ PS A Y + + E Sbjct: 10 LKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRS----LAYLRTECYGY 65 Query: 325 AIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQ 384 A+ + ++++ + RA + + + A++DYET + +D+ + ++ Sbjct: 66 ALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQECN 125 Query: 385 RLLKQSQ 391 +++KQ Sbjct: 126 KIVKQKA 132 >5G04-F nrPDB Length = 824 Score = 70.9 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 55/283 (19%), Positives = 97/283 (34%), Gaps = 27/283 (9%) Query: 38 EKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKV 97 E G + A+ F A+ DP+ AY F+ + AL Sbjct: 568 EAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNA 627 Query: 98 IQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRL 157 I++ A G + KQ K AE F+K L NP QS ++ + Sbjct: 628 IRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINP--------QSSVLLCHIG--V 677 Query: 158 RSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKL 217 AL A+ L+K + + + + RA + + A+ +L+ ++ Sbjct: 678 VQHALK-----KSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQI 732 Query: 218 KNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEE 277 + ++ I +Y +LG L+L + LD K K+ L + E Sbjct: 733 VPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDP--KGANNQIKEAIDKRYLPDDEEP 790 Query: 278 LIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDE 320 + ++ E +M T+ S + + H DE Sbjct: 791 ITQE----------EQIMGTDESQESSMTDADDTQLHAAESDE 823 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 39/260 (15%), Positives = 99/260 (38%), Gaps = 26/260 (10%) Query: 197 CFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHK 256 CF + E AI + A ++ + A+ + + + + +L+ R ++++ H Sbjct: 576 CFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHY 635 Query: 257 RCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCF 316 + + + AE + + S SV+ + ++ ++ E+ Sbjct: 636 NAWYGLGMIYYKQEKFSLAEMHFQKALDINPQS---SVLLCHIGVVQHALKKSEK----- 687 Query: 317 SKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQI 376 A+ ++ + ++P N RA E Y A+Q+ E ++ + + Sbjct: 688 --------ALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLV 739 Query: 377 REGLEKAQRLLKQS--QKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKK 434 + K + L Q+ ++ + + +I +A K ++ PD +EE Sbjct: 740 YFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDK---RYLPD----DEEPIT 792 Query: 435 AEKKFIDIAAAKE-VLSDPE 453 E++ + ++E ++D + Sbjct: 793 QEEQIMGTDESQESSMTDAD 812 Score = 37.0 bits (84), Expect = 0.019, Method: Composition-based stats. Identities = 42/243 (17%), Positives = 87/243 (35%), Gaps = 22/243 (9%) Query: 133 KSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAI-AFLDKILEVCVWDAELR 191 K+ N+ Q + S E+ +L S ++ T I AF + + LR Sbjct: 408 KTKSKTNKGGITQPNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLR 467 Query: 192 ELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKL 251 E+ + ++ + K A + + Y + Q+G LSE + ++ Sbjct: 468 EM-GKGYLALCSY-----NCKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERI 521 Query: 252 DQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKER 311 + +V+++ E+ + SV+ + + + S E Sbjct: 522 ----------FSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKD--LTDMDKNSPEA 569 Query: 312 IC---HCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQE 368 C +CFS + AI+ +Q++P+ A +++ E D+A+ + A Sbjct: 570 WCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIR 629 Query: 369 HNE 371 N Sbjct: 630 VNP 632 >2GW1-A nrPDB Length = 514 Score = 68.2 bits (165), Expect = 7e-12, Method: Composition-based stats. Identities = 61/341 (17%), Positives = 123/341 (36%), Gaps = 27/341 (7%) Query: 44 GKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMD 103 G + + DA+ ++ A++ D + Y + ++++G K + TK ++LK D Sbjct: 13 GNQFFRNKKYDDAIKYYNWALELKED-PVFYSNLSACYVSVGDLKKVVEMSTKALELKPD 71 Query: 104 FTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALN 163 ++ L+R GK +A D VL N N I+ + L QA++ Sbjct: 72 YSKVLLRRASANEGLGKFADAMFD-LSVLSLNGDFN------DASIEPMLERNLNKQAMS 124 Query: 164 AFGS--GDYTAAIAFLDKIL-----EVCVWDAELRELRAEC-FIKEGEPRKAISDLKAAS 215 GD A A ++ E L + + F +P ++ ++ Sbjct: 125 KLKEKFGDIDTATATPTELSTQPAKERKDKQENLPSVTSMASFFGIFKPELTFANYDESN 184 Query: 216 KLKNDNTEA---FYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLI 272 + + YK S Y D + + +LD++++ + K I Sbjct: 185 EADKELMNGLSNLYKRSPESYDKADESFTKAARLFEEQLDKNNE------DEKLKEKLAI 238 Query: 273 ESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEV 332 I D +E + K V S + + E + Sbjct: 239 SLEHTGIFKFLKNDPLGAHEDIKKAIELFPR--VNSYIYMALIMADRNDSTEYYNYFDKA 296 Query: 333 LQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNEND 373 L+++ +N + R + I + YD+A +D++ A+E + + Sbjct: 297 LKLDSNNSSVYYHRGQMNFILQNYDQAGKDFDKAKELDPEN 337 Score = 45.9 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 49/264 (18%), Positives = 98/264 (37%), Gaps = 16/264 (6%) Query: 157 LRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASK 216 L+ + F + Y AI + + LE+ D + C++ G+ +K + A + Sbjct: 9 LKDKGNQFFRNKKYDDAIKYYNWALELK-EDPVFYSNLSACYVSVGDLKKVVEMSTKALE 67 Query: 217 LKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAE 276 LK D ++ + ++ LG ++ ++ L L+ D + LNK ++ Sbjct: 68 LKPDYSKVLLRRASANEGLGKFADAMFDL-SVLSLNGDFNDASIEPMLERNLNK--QAMS 124 Query: 277 ELIRDGRYTDATSKYESVMKTEPSI----AEYTVRSKERICHCFS--KDEKPVEAIRVCS 330 +L D + + + T+P+ + + S + F K E + Sbjct: 125 KLKEKFGDIDTATATPTELSTQPAKERKDKQENLPSVTSMASFFGIFKPELTFANYDESN 184 Query: 331 EVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLLKQS 390 E + + ++ L R+ E YD+A + + A E EK + L S Sbjct: 185 EADKELMNGLSNLYKRSP-----ESYDKADESFTKAARLFEEQLDKNNEDEKLKEKLAIS 239 Query: 391 QKRD-YYKILGVKRNAKKQEIIKA 413 + +K L ++I KA Sbjct: 240 LEHTGIFKFLKNDPLGAHEDIKKA 263 Score = 42.4 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 54/284 (19%), Positives = 103/284 (36%), Gaps = 50/284 (17%) Query: 124 AEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEV 183 A +D KK ++ P N LI +D D T + DK L++ Sbjct: 256 AHEDIKKAIELFPRVNSYIYMA--LIMADR--------------NDSTEYYNYFDKALKL 299 Query: 184 CVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLS 243 ++ + R + +A D A +L +N + +++ L Y+ + Sbjct: 300 DSNNSSVYYHRGQMNFILQNYDQAGKDFDKAKELDPENIFPYIQLACLAYR-------EN 352 Query: 244 EVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTE----- 298 + +C L + KR F +V AE L + A +Y+ ++ E Sbjct: 353 KFDDCETLFSEAKRKFPEAPEVPNF-----FAEILTDKNDFDKALKQYDLAIELENKLDG 407 Query: 299 ------PSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLI 352 P + + T+ ++ F +EA + + +++P + A A+ L Sbjct: 408 IYVGIAPLVGKATLLTRNPTVENF------IEATNLLEKASKLDPRSEQAKIGLAQMKLQ 461 Query: 353 EEMYDEAIQDYETAQEHN----ENDQQIR-EGLEKAQRLLKQSQ 391 +E DEAI +E + + E Q I K Q+ ++ Sbjct: 462 QEDIDEAITLFEESADLARTMEEKLQAITFAEAAKVQQRIRSDP 505 Score = 36.3 bits (82), Expect = 0.035, Method: Composition-based stats. Identities = 43/240 (17%), Positives = 80/240 (33%), Gaps = 35/240 (14%) Query: 56 ALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLL 115 A A++ P +Y A + S K ++L + ++ RG + Sbjct: 256 AHEDIKKAIELFP-RVNSYIYMALIMADRNDSTEYYNYFDKALKLDSNNSSVYYHRGQMN 314 Query: 116 LKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLI-----KSDEMQRLRSQALNAFGSGDY 170 D+A DF K + +P EN Q + K D+ + L S+A F Sbjct: 315 FILQNYDQAGKDFDKAKELDP-ENIFPYIQLACLAYRENKFDDCETLFSEAKRKFPEA-- 371 Query: 171 TAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKIS- 229 E+ AE + + KA+ A +L+N + I+ Sbjct: 372 -----------------PEVPNFFAEILTDKNDFDKALKQYDLAIELENKLDGIYVGIAP 414 Query: 230 --------TLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRD 281 T + + + + + + KLD ++ Q+K + I+ A L + Sbjct: 415 LVGKATLLTRNPTVENFIEATNLLEKASKLDPRSEQAKIGLAQMKLQQEDIDEAITLFEE 474 >4I2W-A nrPDB Length = 961 Score = 65.2 bits (157), Expect = 6e-11, Method: Composition-based stats. Identities = 27/128 (21%), Positives = 51/128 (39%), Gaps = 5/128 (3%) Query: 147 QLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCV-WDAELR----ELRAECFIKE 201 + + + +R + A DY A + L++ D LR RA +K Sbjct: 1 MVARVQTAEEIRDEGNAAVKDQDYIKADELYTEALQLTTDEDKALRPVLYRNRAMARLKR 60 Query: 202 GEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAH 261 + A SD A + + +A ++ S QLG+ + + +E L+L + K Sbjct: 61 DDFEGAQSDCTKALEFDGADVKALFRRSLAREQLGNVGPAFQDAKEALRLSPNDKGIVEV 120 Query: 262 YKQVKKLN 269 +++ K N Sbjct: 121 LQRLVKAN 128 Score = 55.1 bits (131), Expect = 6e-08, Method: Composition-based stats. Identities = 24/124 (19%), Positives = 47/124 (37%), Gaps = 5/124 (4%) Query: 44 GKKLLAAGQLADALSQFHAAVDGDPDN-----YIAYYRRATVFLAMGKSKAALPDLTKVI 98 G + A + A+ D + Y RA L + A D TK + Sbjct: 15 GNAAVKDQDYIKADELYTEALQLTTDEDKALRPVLYRNRAMARLKRDDFEGAQSDCTKAL 74 Query: 99 QLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLR 158 + A +R + G + A D K+ L+ +P++ E +L+K++ + + Sbjct: 75 EFDGADVKALFRRSLAREQLGNVGPAFQDAKEALRLSPNDKGIVEVLQRLVKANNDKIKQ 134 Query: 159 SQAL 162 + +L Sbjct: 135 TTSL 138 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 24/92 (26%), Positives = 40/92 (43%), Gaps = 10/92 (10%) Query: 329 CSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLLK 388 C++ L+ + +V AL R+ A A QD + A + ND+ I E L QRL+K Sbjct: 70 CTKALEFDGADVKALFRRSLAREQLGNVGPAFQDAKEALRLSPNDKGIVEVL---QRLVK 126 Query: 389 QSQKRDYYKILGVKRNAKKQEIIKAYRKLALQ 420 + + +K+ + KLA + Sbjct: 127 ANNDK-------IKQTTSLANKVTDMEKLAFR 151 >1QZ2-A nrPDB Length = 336 Score = 62.1 bits (149), Expect = 6e-10, Method: Composition-based stats. Identities = 41/218 (18%), Positives = 74/218 (33%), Gaps = 36/218 (16%) Query: 66 GDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAE 125 G+ +N Y M K + ++ LK + A G + E + Sbjct: 70 GEGENLDLPYGLERAIQRMEKGE------HSIVYLKPSY--AFGSVGKEKFQIPPNAELK 121 Query: 126 -----DDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKI 180 F+K +S +EEK QS ++K + F G Y A+ KI Sbjct: 122 YELHLKSFEKAKESWEMNSEEKLEQSTIVK--------ERGTVYFKEGKYKQALLQYKKI 173 Query: 181 L------------EVCVWDAELRE---LRAECFIKEGEPRKAISDLKAASKLKNDNTEAF 225 + E A A C +K AI A +L ++N + Sbjct: 174 VSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGL 233 Query: 226 YKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYK 263 ++ + + D EL+ ++ ++ L+L ++K Sbjct: 234 FRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLA 271 Score = 50.1 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 24/107 (22%), Positives = 49/107 (45%), Gaps = 2/107 (1%) Query: 290 KYESVMKTEPSIAEYTVR--SKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRA 347 +YES E + +R S + C K + AI C++ L+++ +N L R Sbjct: 178 EYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRG 237 Query: 348 EAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLLKQSQKRD 394 EA+L ++ A D++ + N++ + L Q+ +++ R+ Sbjct: 238 EAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLARE 284 Score = 49.8 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 28/138 (20%), Positives = 45/138 (32%), Gaps = 15/138 (10%) Query: 42 ELGKKLLAAGQLADALSQFHA---------------AVDGDPDNYIAYYRRATVFLAMGK 86 E G G+ AL Q+ A ++ A L + Sbjct: 152 ERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQA 211 Query: 87 SKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQS 146 AA+ K ++L + +RG L + A DF+KVL+ P+ K + Sbjct: 212 FSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLA 271 Query: 147 QLIKSDEMQRLRSQALNA 164 + Q R + L A Sbjct: 272 VCQQRIRRQLAREKKLYA 289 Score = 46.7 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 30/131 (22%), Positives = 51/131 (38%), Gaps = 2/131 (1%) Query: 39 KHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVI 98 HL L L + A+ + A++ D +N +RR LA+ + A D KV+ Sbjct: 198 SHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVL 257 Query: 99 QLKMDFTAARLQRGHLLLKQGK-LDEAEDDFKKVLK-SNPSENEEKEAQSQLIKSDEMQR 156 QL + AA+ Q + + L + + + + EN+ K S + + Sbjct: 258 QLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEM 317 Query: 157 LRSQALNAFGS 167 Q N GS Sbjct: 318 KEEQKSNTAGS 328 >5OMP-A nrPDB Length = 462 Score = 60.9 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 30/160 (18%), Positives = 58/160 (36%), Gaps = 23/160 (14%) Query: 126 DDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKIL---- 181 F+K +S + +EK Q+ ++K + F G Y A+ KI+ Sbjct: 253 KSFEKAKESWEMDTKEKLEQAAIVK--------EKGTVYFKGGKYMQAVIQYGKIVSWLE 304 Query: 182 --------EVCVWDAELRE---LRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKIST 230 E ++ L A C++K E KA+ A L + N + Y+ Sbjct: 305 MEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGE 364 Query: 231 LYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNK 270 + + E + + + L+++ +K +K K Sbjct: 365 AQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAK 404 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 29/143 (20%), Positives = 63/143 (44%), Gaps = 11/143 (7%) Query: 263 KQVKKLNKLIESAEELIRDGRYTDATSKYESV---MKTEPSIAEYTVRSKE--------R 311 +++++ + E + G+Y A +Y + ++ E ++E ++ E Sbjct: 268 EKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLN 327 Query: 312 ICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNE 371 + C+ K + +A+ C + L ++ N L R EA L+ ++ A D+E E N Sbjct: 328 LAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNP 387 Query: 372 NDQQIREGLEKAQRLLKQSQKRD 394 ++ R + Q+ K+ +RD Sbjct: 388 QNKAARLQISMCQKKAKEHNERD 410 Score = 49.0 bits (115), Expect = 5e-06, Method: Composition-based stats. Identities = 29/143 (20%), Positives = 48/143 (33%), Gaps = 17/143 (11%) Query: 42 ELGKKLLAAGQLADALSQFHAAVD---------------GDPDNYIAYYRRATVFLAMGK 86 E G G+ A+ Q+ V + A+ A +L + + Sbjct: 278 EKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLRE 337 Query: 87 SKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQS 146 A+ K + L +RG L + + A+ DF+KVL+ NP + S Sbjct: 338 YTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQIS 397 Query: 147 QLIK--SDEMQRLRSQALNAFGS 167 K + +R R N F Sbjct: 398 MCQKKAKEHNERDRRIYANMFKK 420 Score = 45.9 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 28/118 (23%), Positives = 47/118 (39%), Gaps = 2/118 (1%) Query: 39 KHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVI 98 L L L + A+ A+ D N YRR L M + ++A D KV+ Sbjct: 324 AFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVL 383 Query: 99 QLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLI--KSDEM 154 ++ AARLQ K + +E + + +E + KE ++ + K+ E Sbjct: 384 EVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKTSEG 441 Score = 45.1 bits (105), Expect = 7e-05, Method: Composition-based stats. Identities = 33/181 (18%), Positives = 65/181 (35%) Query: 60 FHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQG 119 + G P I + + + A + K++ A ++G + K G Sbjct: 228 YGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGG 287 Query: 120 KLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDK 179 K +A + K++ E E +S+ +S + + A+ +YT A+ DK Sbjct: 288 KYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDK 347 Query: 180 ILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHE 239 L + + + R E + E A D + ++ N A +IS + +H Sbjct: 348 ALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHN 407 Query: 240 L 240 Sbjct: 408 E 408 >1KT1-A nrPDB Length = 457 Score = 59.8 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 30/160 (18%), Positives = 58/160 (36%), Gaps = 23/160 (14%) Query: 126 DDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKIL---- 181 F+K +S + +EK Q+ ++K + F G Y A+ KI+ Sbjct: 248 KSFEKAKESWEMDTKEKLEQAAIVK--------EKGTVYFKGGKYVQAVIQYGKIVSWLE 299 Query: 182 --------EVCVWDAELRE---LRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKIST 230 E ++ L A C++K E KA+ A L + N + Y+ Sbjct: 300 MEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGE 359 Query: 231 LYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNK 270 + + E + + + L+++ +K +K K Sbjct: 360 AQLLMNEFESAKGDFEKVLEVNPQNKAARLQIFMCQKKAK 399 Score = 57.1 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 29/143 (20%), Positives = 63/143 (44%), Gaps = 11/143 (7%) Query: 263 KQVKKLNKLIESAEELIRDGRYTDATSKYESV---MKTEPSIAEYTVRSKE--------R 311 +++++ + E + G+Y A +Y + ++ E ++E ++ E Sbjct: 263 EKLEQAAIVKEKGTVYFKGGKYVQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLN 322 Query: 312 ICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNE 371 + C+ K + +A+ C + L ++ N L R EA L+ ++ A D+E E N Sbjct: 323 LAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNP 382 Query: 372 NDQQIREGLEKAQRLLKQSQKRD 394 ++ R + Q+ K+ +RD Sbjct: 383 QNKAARLQIFMCQKKAKEHNERD 405 Score = 49.0 bits (115), Expect = 5e-06, Method: Composition-based stats. Identities = 36/183 (19%), Positives = 64/183 (34%), Gaps = 20/183 (10%) Query: 42 ELGKKLLAAGQLADALSQFHAAVD---------------GDPDNYIAYYRRATVFLAMGK 86 E G G+ A+ Q+ V + A+ A +L + + Sbjct: 273 EKGTVYFKGGKYVQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLRE 332 Query: 87 SKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQS 146 A+ K + L +RG L + + A+ DF+KVL+ NP +N+ Q Sbjct: 333 YTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNP-QNKAARLQI 391 Query: 147 QLIK---SDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRE-LRAECFIKEG 202 + + + +R R N F A +K + + E L A ++E Sbjct: 392 FMCQKKAKEHNERDRRTYANMFKKFAEQDAKEEANKAMSKKTSEGVTNEKLTASHAVEEE 451 Query: 203 EPR 205 +P Sbjct: 452 KPE 454 Score = 45.9 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 28/126 (22%), Positives = 50/126 (39%) Query: 39 KHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVI 98 L L L + A+ A+ D N YRR L M + ++A D KV+ Sbjct: 319 AFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVL 378 Query: 99 QLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLR 158 ++ AARLQ K + +E + + +E + KE ++ + + + Sbjct: 379 EVNPQNKAARLQIFMCQKKAKEHNERDRRTYANMFKKFAEQDAKEEANKAMSKKTSEGVT 438 Query: 159 SQALNA 164 ++ L A Sbjct: 439 NEKLTA 444 Score = 43.2 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 32/181 (17%), Positives = 64/181 (35%) Query: 60 FHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQG 119 + G P I + + + A + K++ A ++G + K G Sbjct: 223 YGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGG 282 Query: 120 KLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDK 179 K +A + K++ E E +S+ +S + + A+ +YT A+ DK Sbjct: 283 KYVQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDK 342 Query: 180 ILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHE 239 L + + + R E + E A D + ++ N A +I + +H Sbjct: 343 ALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQIFMCQKKAKEHN 402 Query: 240 L 240 Sbjct: 403 E 403 >2C2L-A nrPDB Length = 281 Score = 59.0 bits (141), Expect = 5e-09, Method: Composition-based stats. Identities = 29/157 (18%), Positives = 61/157 (38%), Gaps = 12/157 (7%) Query: 151 SDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISD 210 S Q L+ Q F Y A A + + A RA C++K +P +A++D Sbjct: 1 SPSAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQQPEQALAD 60 Query: 211 LKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNK 270 + A +L + +A + + ++ ++ +++ ++ L ++ + F Sbjct: 61 CRRALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRAYSLAKEQRLNFGD--------- 111 Query: 271 LIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVR 307 I SA + + R+ E + E + Y R Sbjct: 112 DIPSALRIAKKKRWNSIE---ERRIHQESELHSYLTR 145 Score = 50.1 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 21/95 (22%), Positives = 41/95 (43%) Query: 37 VEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTK 96 ++ E G +L + +A + + A+ +P + Y RA +L M + + AL D + Sbjct: 4 AQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQQPEQALADCRR 63 Query: 97 VIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKV 131 ++L A G L+ DEA + ++ Sbjct: 64 ALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRA 98 Score = 45.9 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 32/132 (24%), Positives = 59/132 (44%), Gaps = 13/132 (9%) Query: 274 SAEELIRDG-------RYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAI 326 SA+EL G +Y +A + Y + P +A Y C+ K ++P +A+ Sbjct: 3 SAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNR----ALCYLKMQQPEQAL 58 Query: 327 RVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRL 386 C L+++ +V A + L E YDEAI + + A + Q++ G + Sbjct: 59 ADCRRALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRAYSLAKE-QRLNFG-DDIPSA 116 Query: 387 LKQSQKRDYYKI 398 L+ ++K+ + I Sbjct: 117 LRIAKKKRWNSI 128 >5MGX-E nrPDB Length = 290 Score = 52.8 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 27/117 (23%), Positives = 52/117 (44%), Gaps = 3/117 (2%) Query: 287 ATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDR 346 +++K + + E + + V+ + K + A+R CS VL+ +PDN+ AL + Sbjct: 163 SSAKVDMTFEEEAQLLQLKVKCLNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRK 222 Query: 347 AEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLLKQSQKRD---YYKILG 400 + + Y EAI A + +++ I L K + + + Y K+LG Sbjct: 223 GKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKKHAAQRSTETALYRKMLG 279 Score = 49.4 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 25/87 (28%), Positives = 39/87 (44%) Query: 76 RRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSN 135 A L + +AAL + V++ + D A ++G +L +QG+ EA + LK Sbjct: 187 NLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLE 246 Query: 136 PSENEEKEAQSQLIKSDEMQRLRSQAL 162 PS S+L+K QR AL Sbjct: 247 PSNKTIHAELSKLVKKHAAQRSTETAL 273 Score = 29.7 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 33/133 (24%), Positives = 58/133 (43%), Gaps = 9/133 (6%) Query: 101 KMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQ 160 K + A QR +L D A K + S+ + E ++QL++ +++ L + Sbjct: 134 KRECGNAHYQRADFVLAANSYDLA----IKAITSSAKVDMTFEEEAQLLQ-LKVKCLNNL 188 Query: 161 ALNAFGSGDYTAAIAFLDKILE--VCVWDAELRELRAECFIKEGEPRKAISDLKAASKLK 218 A + Y AA+ +LE A R+ + ++GE +AI L+AA KL+ Sbjct: 189 AASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLA--QQGEYSEAIPILRAALKLE 246 Query: 219 NDNTEAFYKISTL 231 N ++S L Sbjct: 247 PSNKTIHAELSKL 259 >4CGU-A nrPDB Length = 112 Score = 52.5 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 13/68 (19%), Positives = 28/68 (41%) Query: 33 VNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALP 92 + + EK E G L G +A+ + + P N + Y +A + +G+ A+ Sbjct: 1 LMSQFEKQKEQGNSLFKQGLYREAVHCYDQLITAQPQNPVGYSNKAMALIKLGEYTQAIQ 60 Query: 93 DLTKVIQL 100 + ++ Sbjct: 61 MCQQGLRY 68 Score = 48.2 bits (113), Expect = 8e-06, Method: Composition-based stats. Identities = 18/84 (21%), Positives = 33/84 (39%), Gaps = 1/84 (1%) Query: 152 DEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDL 211 + ++ + Q + F G Y A+ D+++ + +A IK GE +AI Sbjct: 3 SQFEKQKEQGNSLFKQGLYREAVHCYDQLITAQPQNPVGYSNKAMALIKLGEYTQAIQMC 62 Query: 212 KAASKLKNDNTEAFYKISTLYYQL 235 + + E S L Y+L Sbjct: 63 QQGLRY-TSTAEHVAIRSKLQYRL 85 >5FZQ-A nrPDB Length = 131 Score = 51.3 bits (121), Expect = 9e-07, Method: Composition-based stats. Identities = 22/94 (23%), Positives = 38/94 (40%) Query: 41 LELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQL 100 L L G+ +A+ AV DP+N A + GK++ A+ + K + L Sbjct: 9 SNLANLLAQEGKAEEAIKYMRKAVSLDPNNIKTLSNLANLLAQEGKAEEAIKYMRKAVSL 68 Query: 101 KMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKS 134 + LL ++GK +EA +K + Sbjct: 69 DPNNIKTLSNLAVLLAQEGKAEEAIKYMRKAVSL 102 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 18/85 (21%), Positives = 38/85 (44%) Query: 167 SGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFY 226 G AI ++ K + + + + A +EG+ +AI ++ A L +N + Sbjct: 18 EGKAEEAIKYMRKAVSLDPNNIKTLSNLANLLAQEGKAEEAIKYMRKAVSLDPNNIKTLS 77 Query: 227 KISTLYYQLGDHELSLSEVRECLKL 251 ++ L Q G E ++ +R+ + L Sbjct: 78 NLAVLLAQEGKAEEAIKYMRKAVSL 102 Score = 36.3 bits (82), Expect = 0.032, Method: Composition-based stats. Identities = 14/62 (22%), Positives = 29/62 (46%) Query: 76 RRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSN 135 A + GK++ A+ + K + L + +LL ++GK +EA +K + + Sbjct: 10 NLANLLAQEGKAEEAIKYMRKAVSLDPNNIKTLSNLANLLAQEGKAEEAIKYMRKAVSLD 69 Query: 136 PS 137 P+ Sbjct: 70 PN 71 Score = 34.3 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 21/109 (19%), Positives = 43/109 (39%), Gaps = 15/109 (13%) Query: 109 LQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSG 168 +LL ++GK +EA +K + +P+ ++ L + A G Sbjct: 9 SNLANLLAQEGKAEEAIKYMRKAVSLDPN---------------NIKTLSNLANLLAQEG 53 Query: 169 DYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKL 217 AI ++ K + + + + A +EG+ +AI ++ A L Sbjct: 54 KAEEAIKYMRKAVSLDPNNIKTLSNLAVLLAQEGKAEEAIKYMRKAVSL 102 Score = 31.7 bits (70), Expect = 0.70, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 35/69 (50%) Query: 305 TVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYE 364 ++++ + + +++ K EAI+ + + ++P+N+ L + A E +EAI+ Sbjct: 4 SIKTLSNLANLLAQEGKAEEAIKYMRKAVSLDPNNIKTLSNLANLLAQEGKAEEAIKYMR 63 Query: 365 TAQEHNEND 373 A + N+ Sbjct: 64 KAVSLDPNN 72 Score = 29.0 bits (63), Expect = 5.3, Method: Composition-based stats. Identities = 19/99 (19%), Positives = 45/99 (45%), Gaps = 4/99 (4%) Query: 268 LNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIR 327 + L A L ++G+ +A + +P+ +++ + + +++ K EAI+ Sbjct: 5 IKTLSNLANLLAQEGKAEEAIKYMRKAVSLDPN----NIKTLSNLANLLAQEGKAEEAIK 60 Query: 328 VCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETA 366 + + ++P+N+ L + A E +EAI+ A Sbjct: 61 YMRKAVSLDPNNIKTLSNLAVLLAQEGKAEEAIKYMRKA 99 >5ZYQ-A nrPDB Length = 320 Score = 51.3 bits (121), Expect = 9e-07, Method: Composition-based stats. Identities = 25/90 (27%), Positives = 41/90 (45%), Gaps = 1/90 (1%) Query: 47 LLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTA 106 LL ++ A +QFH ++ P+N A +A + + AL K ++ A Sbjct: 139 LLEGDKMDQADAQFHFVLNQSPNNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPA 198 Query: 107 -ARLQRGHLLLKQGKLDEAEDDFKKVLKSN 135 RL GH +K KL++A F + L+ N Sbjct: 199 EVRLGMGHCFVKLNKLEKARLAFSRALELN 228 Score = 34.3 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 35/150 (23%), Positives = 57/150 (38%), Gaps = 23/150 (15%) Query: 115 LLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAI 174 LL+ K+D+A+ F VL +P+ + L +A +F DY A+ Sbjct: 139 LLEGDKMDQADAQFHFVLNQSPNN---------------IPALLGKACISFNKKDYRGAL 183 Query: 175 AFLDKILEVC-VWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYY 233 A+ K L AE+R CF+K + KA A +L + A ++ L Sbjct: 184 AYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKARLAFSRALELNSKCVGALVGLAVL-- 241 Query: 234 QLGDHELSLSEVRECLKLDQDHKRCFAHYK 263 + ++ E L + F YK Sbjct: 242 ---ELNNKEADGSENLYFQSGSR--FVQYK 266 Score = 30.5 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 17/61 (27%), Positives = 27/61 (44%) Query: 311 RICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHN 370 R C C + +K +A VL P+N+ AL +A ++ Y A+ Y+ A N Sbjct: 134 RACFCLLEGDKMDQADAQFHFVLNQSPNNIPALLGKACISFNKKDYRGALAYYKKALRTN 193 Query: 371 E 371 Sbjct: 194 P 194 >5JHE-A nrPDB Length = 397 Score = 51.3 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 23/78 (29%), Positives = 45/78 (57%), Gaps = 4/78 (5%) Query: 320 EKPVEAIRVCSEVLQMEP----DNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQ 375 E+ +AI + +L+M+ D A R +YL ++ DEA+QDY +E N +D+ Sbjct: 310 ERYDDAIMYATYLLEMDNVPNRDQAKAYYRRGNSYLKKKRLDEALQDYIFCKEKNPDDEV 369 Query: 376 IREGLEKAQRLLKQSQKR 393 I + +E RL+++++++ Sbjct: 370 IEQRIEYVNRLIEENKEK 387 Score = 39.4 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 23/119 (19%), Positives = 46/119 (38%), Gaps = 22/119 (18%) Query: 42 ELGKKLLAAGQLADALSQFHAAVD------GDPD------------NYIAYYRRATVFLA 83 E G L ++A ++ +++ +PD Y + V Sbjct: 249 ESGTLLFKKKDYSNAFFKYRKSLNYINEYMPEPDVDKERNIQFINLKMKIYLNLSLVLFN 308 Query: 84 MGKSKAALPDLTKVIQL----KMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSE 138 + + A+ T ++++ D A +RG+ LK+ +LDEA D+ + NP + Sbjct: 309 LERYDDAIMYATYLLEMDNVPNRDQAKAYYRRGNSYLKKKRLDEALQDYIFCKEKNPDD 367 Score = 36.3 bits (82), Expect = 0.029, Method: Composition-based stats. Identities = 18/75 (24%), Positives = 29/75 (38%), Gaps = 4/75 (5%) Query: 33 VNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDP----DNYIAYYRRATVFLAMGKSK 88 +N ++ +L L L + DA+ ++ D D AYYRR +L + Sbjct: 292 INLKMKIYLNLSLVLFNLERYDDAIMYATYLLEMDNVPNRDQAKAYYRRGNSYLKKKRLD 351 Query: 89 AALPDLTKVIQLKMD 103 AL D + D Sbjct: 352 EALQDYIFCKEKNPD 366 Score = 34.7 bits (78), Expect = 0.10, Method: Composition-based stats. Identities = 16/93 (17%), Positives = 36/93 (38%), Gaps = 7/93 (7%) Query: 193 LRAECFIKEGEPRKAISDLKAASKLKN----DNTEAFYKISTLYYQLGDHELSLSEVREC 248 + AI ++ N D +A+Y+ Y + + +L + C Sbjct: 301 NLSLVLFNLERYDDAIMYATYLLEMDNVPNRDQAKAYYRRGNSYLKKKRLDEALQDYIFC 360 Query: 249 LKLDQDHKRCFAHYKQVKKLNKLIESAEELIRD 281 + + D + ++++ +N+LIE +E R Sbjct: 361 KEKNPDDE---VIEQRIEYVNRLIEENKEKTRK 390 >2IF4-A nrPDB Length = 338 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 27/88 (30%), Positives = 40/88 (45%), Gaps = 2/88 (2%) Query: 312 ICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNE 371 I C K ++ EAI C+ VL E N AL R +A D A D+ AQ++ Sbjct: 236 IAACLIKLKRYDEAIGHCNIVLTEEEKNPKALFRRGKAKAELGQMDSARDDFRKAQKYAP 295 Query: 372 NDQQIREGL--EKAQRLLKQSQKRDYYK 397 +D+ IR L Q ++++ YK Sbjct: 296 DDKAIRRELRALAEQEKALYQKQKEMYK 323 Score = 45.5 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 25/136 (18%), Positives = 50/136 (36%), Gaps = 17/136 (12%) Query: 44 GKKLLAAGQLADALSQFHAAVD--GDPDNYIAY---------------YRRATVFLAMGK 86 G L +L +A+ Q+ A+ GD + Y A + + + Sbjct: 186 GNSLFKEEKLEEAMQQYEMAIAYMGDDFMFQLYGKYQDMALAVKNPCHLNIAACLIKLKR 245 Query: 87 SKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQS 146 A+ V+ + A +RG + G++D A DDF+K K P + + Sbjct: 246 YDEAIGHCNIVLTEEEKNPKALFRRGKAKAELGQMDSARDDFRKAQKYAPDDKAIRRELR 305 Query: 147 QLIKSDEMQRLRSQAL 162 L + ++ + + + Sbjct: 306 ALAEQEKALYQKQKEM 321 Score = 45.1 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 20/145 (13%), Positives = 43/145 (29%), Gaps = 17/145 (11%) Query: 155 QRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRE-----------------LRAEC 197 R + + F A+ + + D + A C Sbjct: 180 DRRKMDGNSLFKEEKLEEAMQQYEMAIAYMGDDFMFQLYGKYQDMALAVKNPCHLNIAAC 239 Query: 198 FIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKR 257 IK +AI + N +A ++ +LG + + + R+ K D K Sbjct: 240 LIKLKRYDEAIGHCNIVLTEEEKNPKALFRRGKAKAELGQMDSARDDFRKAQKYAPDDKA 299 Query: 258 CFAHYKQVKKLNKLIESAEELIRDG 282 + + + K + ++ + G Sbjct: 300 IRRELRALAEQEKALYQKQKEMYKG 324 Score = 37.0 bits (84), Expect = 0.019, Method: Composition-based stats. Identities = 18/93 (19%), Positives = 38/93 (40%) Query: 40 HLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQ 99 HL + L+ + +A+ + + + N A +RR +G+ +A D K + Sbjct: 233 HLNIAACLIKLKRYDEAIGHCNIVLTEEEKNPKALFRRGKAKAELGQMDSARDDFRKAQK 292 Query: 100 LKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVL 132 D A R + L ++ L + + + K + Sbjct: 293 YAPDDKAIRRELRALAEQEKALYQKQKEMYKGI 325 >5Y88-T nrPDB Length = 283 Score = 49.4 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 18/77 (23%), Positives = 35/77 (45%), Gaps = 10/77 (12%) Query: 391 QKRDYYKILGVKRN-------AKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIA 443 Q+ + Y +L + +I + YR LAL++HPD + KF ++ Sbjct: 12 QRLNLYDVLELPTPLDVHTIYDDLPQIKRKYRTLALKYHPDKHP---DNPSIIHKFHLLS 68 Query: 444 AAKEVLSDPEMRKKFDD 460 A +L++ ++R +D Sbjct: 69 TATNILTNADVRPHYDR 85 >4ZLH-A nrPDB Length = 339 Score = 49.0 bits (115), Expect = 5e-06, Method: Composition-based stats. Identities = 41/212 (19%), Positives = 75/212 (35%), Gaps = 21/212 (9%) Query: 37 VEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTK 96 VE HL LG + G++ A+ ++ + Y +R +G+ A + Sbjct: 19 VEAHLTLGNLFRSRGEVDRAIRIHQTLMESAS---LTYEQRLLAIQQLGRDYMAAGLYDR 75 Query: 97 VIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIK-SDEMQ 155 + T R L + ++ +A +++K + +L+K + Q Sbjct: 76 AEDMFNQLTDETDFRIGALQQLLQIYQATSEWQKAIDV----------AERLVKLGKDKQ 125 Query: 156 RLR------SQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAIS 209 R+ AL S D A+ L K A + + F+ +GE KA+ Sbjct: 126 RVEIAHFYCELALQHMASDDLDRAMTLLKKGAAADKNSARVSIMMGRVFMAKGEYAKAVE 185 Query: 210 DLKAASKLKND-NTEAFYKISTLYYQLGDHEL 240 L+ + +E + T Y QLG Sbjct: 186 SLQRVISQDRELVSETLEMLQTCYQQLGKTAE 217 >5WQL-B nrPDB Length = 278 Score = 47.4 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 40/191 (20%), Positives = 70/191 (36%), Gaps = 16/191 (8%) Query: 42 ELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLK 101 E G + G A A + F A+ PD + G AA V++L Sbjct: 51 ERGVLYDSLGLRALARNDFSQALAIRPDMPEVFNYLGIYLTQAGNFDAAYEAFDSVLELD 110 Query: 102 MDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSEN-------------EEKEAQSQL 148 + A L RG L G+ A+DD + +P++ +EK+A+ L Sbjct: 111 PTYNYAHLNRGIALYYGGRDKLAQDDLLAFYQDDPNDPFRSLWLYLAEQKLDEKQAKEVL 170 Query: 149 IKSDEMQRLRSQALN--AFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRK 206 + E N F G+ + ++++ + L E +E G+ Sbjct: 171 KQHFEKSDKEQWGWNIVEFYLGNISEQ-TLMERLKADATDNTSLAEHLSETNFYLGKYYL 229 Query: 207 AISDLKAASKL 217 ++ DL +A+ L Sbjct: 230 SLGDLDSATAL 240 >5DSE-A nrPDB Length = 837 Score = 46.3 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 19/99 (19%), Positives = 34/99 (34%) Query: 44 GKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMD 103 G+ G + +A + A+ P + + R A + +G+ A L +Q+ Sbjct: 731 GQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNST 790 Query: 104 FTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEK 142 G +L QG A + F L+ S Sbjct: 791 AHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVP 829 Score = 38.6 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 36/179 (20%), Positives = 64/179 (35%), Gaps = 9/179 (5%) Query: 49 AAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMD----- 103 GQ A+ + + +Y+ A +A GKS A+ L + I+LK D Sbjct: 369 RRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIP 428 Query: 104 FTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALN 163 AA+L G L L+EAE K V+ +E K + + +L Sbjct: 429 LLAAKLCMGSLHW----LEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTYSLQATDASLR 484 Query: 164 AFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNT 222 A+ + + D + A + +A+ ++ A +L+ D+ Sbjct: 485 GMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDA 543 Score = 30.1 bits (66), Expect = 2.1, Method: Composition-based stats. Identities = 35/143 (24%), Positives = 55/143 (38%), Gaps = 28/143 (19%) Query: 78 ATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPS 137 A V++ +GK A + L RG + +G +DEA +++ L +P+ Sbjct: 697 AEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPT 756 Query: 138 ENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEV-----CVWDAELRE 192 +KS MQRL AL G Y+ A L ++V VW+ Sbjct: 757 H----------VKS--MQRL---ALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEV 801 Query: 193 LRA--------ECFIKEGEPRKA 207 L+A ECF+ E + Sbjct: 802 LQAQGNDAAATECFLTALELEAS 824 Score = 29.7 bits (65), Expect = 3.0, Method: Composition-based stats. Identities = 15/51 (29%), Positives = 21/51 (41%) Query: 321 KPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNE 371 KP EA E + P + N L R + + DEA + YE A + Sbjct: 705 KPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISP 755 >5G04-X nrPDB Length = 599 Score = 46.3 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 51/318 (16%), Positives = 113/318 (35%), Gaps = 33/318 (10%) Query: 69 DNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDF 128 DN A ++ G +K ++ + L G+LL ++G+L++ E+ Sbjct: 269 DNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLG 328 Query: 129 KKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDA 188 ++ + ++ E S ++F S Y+ A+ K +++ Sbjct: 329 CRLFNIS-DQHAEPWVVS--------------GCHSFYSKRYSRALYLGAKAIQLNSNSV 373 Query: 189 ELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVREC 248 + L+ G ++AI + A +L + + + Y ++ Sbjct: 374 QALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNV 433 Query: 249 LKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRS 308 K + + V + + + + + D + P + V+ Sbjct: 434 YKTLGANAQTLTLLATVCLEDPVTQEKAKTLLD-----------KALTQRPDYIKAVVKK 482 Query: 309 KERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLI-EEMYDEAIQDYETAQ 367 E + S+++K + I + L + D V L +L+ Y EA+ Y A Sbjct: 483 AELL----SREQKYEDGIALLRNALANQSDCV--LHRILGDFLVAVNEYQEAMDQYSIAL 536 Query: 368 EHNENDQQIREGLEKAQR 385 + NDQ+ EG++K ++ Sbjct: 537 SLDPNDQKSLEGMQKMEK 554 Score = 37.4 bits (85), Expect = 0.014, Method: Composition-based stats. Identities = 33/202 (16%), Positives = 66/202 (32%), Gaps = 16/202 (7%) Query: 24 LQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLA 83 L + + N+ V+ L G L G++ +A+ F A+ P Y +LA Sbjct: 361 LGAKAIQLNSNS-VQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLA 419 Query: 84 MGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKE 143 + A+ V G L A + + ++ + Sbjct: 420 SNSIREAMVMANNV----------YKTLGANAQTLTLL--ATVCLEDPVTQEKAKTLLDK 467 Query: 144 AQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGE 203 A +Q + +++ L+ Y IA L L D L + + + E Sbjct: 468 ALTQRPDYIKAVVKKAELLS--REQKYEDGIALLRNAL-ANQSDCVLHRILGDFLVAVNE 524 Query: 204 PRKAISDLKAASKLKNDNTEAF 225 ++A+ A L ++ ++ Sbjct: 525 YQEAMDQYSIALSLDPNDQKSL 546 >1FPO-A nrPDB Length = 171 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 20/83 (24%), Positives = 37/83 (44%), Gaps = 4/83 (4%) Query: 394 DYYKILGVKR--NAKKQEIIKAYRKLALQWHPDNFQNEEEKKK--AEKKFIDIAAAKEVL 449 DY+ + G+ Q + ++ L Q+HPD F + + ++ A ++ I A + L Sbjct: 2 DYFTLFGLPARYQLDTQALSLRFQDLQRQYHPDKFASGSQAEQLAAVQQSATINQAWQTL 61 Query: 450 SDPEMRKKFDDGEDPLDAESQQG 472 P MR ++ D S+Q Sbjct: 62 RHPLMRAEYLLSLHGFDLASEQH 84 >4IT5-A nrPDB Length = 174 Score = 44.0 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 19/90 (21%), Positives = 41/90 (45%), Gaps = 4/90 (4%) Query: 394 DYYKILG--VKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKK--AEKKFIDIAAAKEVL 449 +Y+++ G ++ + +R L ++HPDNF E+ + A ++ I A + L Sbjct: 5 NYFELFGLPIQFELDGSLLSSQFRALQKRFHPDNFATASERDRLMAVQQAAQINDAYQTL 64 Query: 450 SDPEMRKKFDDGEDPLDAESQQGGGGNPFH 479 DP R ++ ++ ++Q +P Sbjct: 65 KDPLRRAEYLLSLQGIEMNAEQQTLQDPMF 94 >4HOQ-A nrPDB Length = 482 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 76/373 (20%), Positives = 135/373 (36%), Gaps = 79/373 (21%) Query: 41 LELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKS-------KAALPD 93 L+ G K A + F A++ +PDN A + S +L Sbjct: 149 LKFGGKY-----YQKAKAAFEKALEVEPDNPEFNIGYAITVYRLDDSDREGSVKSFSLGP 203 Query: 94 LTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDE 153 L K + L D + ++ L LK + AE + +K ++ E Q+ S + Sbjct: 204 LRKAVTLNPDNSYIKV---FLALKLQDV-HAEAEGEKYIE---------EILDQI--SSQ 248 Query: 154 MQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECF--------------- 198 LR A + A+ L K LEV + L C+ Sbjct: 249 PYVLRYAAKFYRRKNSWNKALELLKKALEVTPTSSFLHHQMGLCYRAQMIQIKKATHNRP 308 Query: 199 -----IKEGEP-RKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLD 252 +K E AI KAA + + A+ ++ +Y + G + + R+ L+L+ Sbjct: 309 KGKDKLKVDELISSAIFHFKAAMERDSMFAFAYTDLANMYAEGGQYSNAEDIFRKALRLE 368 Query: 253 Q---DHK-RCFAHYKQVKKLNKLIESAEELIRDGRYTDATS-KYESVMKTEPSIAEYTVR 307 DHK + HY + ++ ++ E+ Y +A K S ++T+ + A + Sbjct: 369 NITDDHKHQIHYHYGRFQEFHRKSENTA----IHHYLEALKVKDRSPLRTKLTSALKKLS 424 Query: 308 SKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQ 367 +K R+CH A+ V +L Y +E +A + YE AQ Sbjct: 425 TK-RLCH---------NALD------------VQSLSALGFVYKLEGEKRQAAEYYEKAQ 462 Query: 368 EHNENDQQIREGL 380 + + + + L Sbjct: 463 KIDPENAEFLTAL 475 Score = 29.7 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 11/40 (27%), Positives = 15/40 (37%) Query: 31 CGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDN 70 C DV+ LG G+ A + A DP+N Sbjct: 429 CHNALDVQSLSALGFVYKLEGEKRQAAEYYEKAQKIDPEN 468 >6AF0-A nrPDB Length = 939 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 41/269 (15%), Positives = 83/269 (30%), Gaps = 59/269 (21%) Query: 42 ELGKKLLAAGQLADALSQFHAAVDG-------------DPDNYIAYYRRATVFLAMGKSK 88 +G G+ A F AA+D D + + G Sbjct: 536 NIGCFYSQEGKHRLATEFFQAALDSCARISQTENDLDIDALLTTIPFNLGRSYEYEGDID 595 Query: 89 AALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSE---------- 138 A+ +++ D+T AR + ++ L++ E D K+ + NPS+ Sbjct: 596 KAIETYEQLLSRHSDYTDARTRLAYIKLRRNPNKEGPDAVAKLYQENPSDLEVRGLYGWF 655 Query: 139 ----NEEKEAQSQ-------------------------------LIKSDEMQRLRSQALN 163 N +K + L+ + EM+R Q Sbjct: 656 LSKVNSKKRPANIAEDPEQRHYKHTLQSYDKHDRYALVGMGNLHLMAAREMRRETEQDRQ 715 Query: 164 AFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTE 223 S Y A+ F DK L++ +A + A +++ + K + + + Sbjct: 716 K-RSAAYNRAVEFFDKALQLDPKNAYAAQGIAIALVEDRKDYKNALQIFIKVRETIQDAH 774 Query: 224 AFYKISTLYYQLGDHELSLSEVRECLKLD 252 + + +Y +L ++ L + Sbjct: 775 VYVNMGHIYAELRQFSKAIESYEIALSKE 803 >5G05-C nrPDB Length = 597 Score = 39.7 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 14/93 (15%), Positives = 36/93 (38%) Query: 39 KHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVI 98 +G + + + A+ + A++ + +Y A+Y + + L + Sbjct: 367 AWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAH 426 Query: 99 QLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKV 131 QL+ + + + G K +L EA+ + + Sbjct: 427 QLRPNDSRMLVALGECYEKLNQLVEAKKCYWRA 459 >5NNP-A nrPDB Length = 745 Score = 39.7 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 50/268 (18%), Positives = 87/268 (32%), Gaps = 37/268 (13%) Query: 46 KLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFT 105 + Q L + +P + +A + A GK++ A + + + M Sbjct: 19 RHYEDKQYKRGLKAAEQILKKNPKHGDTMSMKALILNAQGKTEEAFALAKEALTIDMKSY 78 Query: 106 AARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQL-IKSDEMQRLRSQALNA 164 G L DEA +K LK P ++ + + L I+ + LN Sbjct: 79 ICWHVYGILYRTNKNFDEAIKAYKFALKLEPESHQIQRDLAVLQIQMRDYAGYVQSRLNM 138 Query: 165 FGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKA--------ASK 216 + W A A + EG KA L K Sbjct: 139 LKARPQIRQ-----------NWTAL-----AIAYHLEGNLEKAEHILTTYEKSLTTPPPK 182 Query: 217 LKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAE 276 +++EA +T+ + GD E +L L+ D K C + +L + A Sbjct: 183 TDLEHSEALLYKNTIIAERGDIERALQH------LETDCKHC------LDRLAVMELRAS 230 Query: 277 ELIRDGRYTDATSKYESVMKTEPSIAEY 304 L + R +A Y +++ P +Y Sbjct: 231 YLSKLARKDEAAKAYRALLDRNPEHMDY 258 Score = 35.5 bits (80), Expect = 0.051, Method: Composition-based stats. Identities = 55/318 (17%), Positives = 99/318 (31%), Gaps = 52/318 (16%) Query: 38 EKHLELGKKLLAAGQLADA---LSQFHAAVDGDPDNYIAYYRRA-----TVFLAMGKSKA 89 + L G L A L+ + ++ P + A T+ G + Sbjct: 147 QNWTALAIAYHLEGNLEKAEHILTTYEKSLTTPPPKTDLEHSEALLYKNTIIAERGDIER 206 Query: 90 ALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLI 149 AL L + +D A R L K + DEA ++ +L NP + + + Sbjct: 207 ALQHLETDCKHCLDRLAVMELRASYLSKLARKDEAAKAYRALLDRNPEHMDYYKGLISAL 266 Query: 150 KSDEMQRLRSQALNAFGSGDYTAAIA------------------------FLDKILEVCV 185 +A+ + Y + A DK + Sbjct: 267 DISADDEEAQKAVYDEYAAKYPRSDAAKRLPLNFLSGERFRTTAKAYLTLMFDKGVPSTF 326 Query: 186 WDAELRELRAECFIKEGEPRKAISDLKAAS-------KLKNDNTE----AFYKISTL--Y 232 + L+ L ++ F KE A L + D ++ A Y ++ Y Sbjct: 327 AN--LKHLYSDSFKKETLASLAEEYLNEYVNARPSDNQADGDGSKGKGAALYYLAQHYNY 384 Query: 233 YQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYE 292 Y D +L V + ++LD + ++ K + A E + R D +Y Sbjct: 385 YMSRDLTRALEYVEKAIELDPKNVDFHMTKARIFKHQGDLAKAAETMDYARSLDPKDRY- 443 Query: 293 SVMKTEPSIAEYTVRSKE 310 A+Y +R+ E Sbjct: 444 ----INSKAAKYQLRNNE 457 Score = 29.0 bits (63), Expect = 5.6, Method: Composition-based stats. Identities = 15/107 (14%), Positives = 40/107 (37%) Query: 151 SDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISD 210 S L + + Y + ++IL+ + ++A +G+ +A + Sbjct: 7 STREANLFRTVIRHYEDKQYKRGLKAAEQILKKNPKHGDTMSMKALILNAQGKTEEAFAL 66 Query: 211 LKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKR 257 K A + + ++ LY + + ++ + LKL+ + + Sbjct: 67 AKEALTIDMKSYICWHVYGILYRTNKNFDEAIKAYKFALKLEPESHQ 113 >6C95-A nrPDB Length = 866 Score = 39.4 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 44/253 (17%), Positives = 91/253 (35%), Gaps = 20/253 (7%) Query: 151 SDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISD 210 ++ + L + L G A + + L + + + + +AI Sbjct: 43 AEHGETLAMKGLTLNCLGKKEEAYELVRRGLRNDLKSHVCWHVYGLLQRSDKKYDEAIKC 102 Query: 211 LKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNK 270 + A K DN + +S L Q+ D E + L+L + + Y L + Sbjct: 103 YRNALKWDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPAQRASWIGYAIAYHLLE 162 Query: 271 LIESAEELIRDGRYTDATS------KYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVE 324 E A +++ + R T TS +Y ++ + + +E + H + +++ Sbjct: 163 DYEMAAKILEEFRKTQQTSPDKVDYEYSELLLYQNQVLREAGLYREALEHLCTYEKQ--- 219 Query: 325 AIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQ 384 +C D + + + E L ++A Y QE N + +GLEKA Sbjct: 220 ---IC--------DKLAVEETKGELLLQLCRLEDAADVYRGLQERNPENWAYYKGLEKAL 268 Query: 385 RLLKQSQKRDYYK 397 + ++ Y+ Sbjct: 269 KPANMLERLKIYE 281 Score = 34.0 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 34/208 (16%), Positives = 78/208 (37%), Gaps = 17/208 (8%) Query: 26 YEGAECGVNADVEKHL---ELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFL 82 YE G+ D++ H+ G + + +A+ + A+ D DN + + + Sbjct: 66 YELVRRGLRNDLKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWDKDNLQILRDLSLLQI 125 Query: 83 AMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAED---DFKKVLKSNPSEN 139 M + +++QL+ A+ + + A +F+K +++P + Sbjct: 126 QMRDLEGYRETRYQLLQLRPAQRASWIGYAIAYHLLEDYEMAAKILEEFRKTQQTSPDKV 185 Query: 140 EEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFI 199 + + E+ ++Q L +G Y A+ L + + E + E + Sbjct: 186 DY--------EYSELLLYQNQVLRE--AGLYREALEHLCTYEKQICDKLAVEETKGELLL 235 Query: 200 KEGEPRKAISDLKAASKLKNDNTEAFYK 227 + A +D+ + +N A+YK Sbjct: 236 QLCRLEDA-ADVYRGLQERNPENWAYYK 262 >4UZY-A nrPDB Length = 651 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 33/188 (17%), Positives = 60/188 (31%), Gaps = 25/188 (13%) Query: 47 LLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTA 106 L+ + A+A+ + P++ A + G+ A +++ L Sbjct: 27 LIKEQKFAEAIQHLQYQLQNVPESRAALSLLGYCYYYTGQYDMASQMYEQLVTLYPSNED 86 Query: 107 ARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLI----KSDEMQRLRSQ-- 160 +L L K G EA KV E +K + L+ + D++ R Q Sbjct: 87 YKLYYAQSLYKGGMYPEASKAVVKV------EGHQKAVTTLLVACSYEQDDLTGCRRQLD 140 Query: 161 -------------ALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKA 207 F G + AA + ++ + EL A C+ K + A Sbjct: 141 KCAPEDPDTMVNTGCIMFKEGKFEAARQKFNDAVQALGYQPELLYNIALCYYKTKQFGPA 200 Query: 208 ISDLKAAS 215 + L Sbjct: 201 LKHLAEII 208 Score = 36.7 bits (83), Expect = 0.022, Method: Composition-based stats. Identities = 57/275 (20%), Positives = 99/275 (36%), Gaps = 43/275 (15%) Query: 199 IKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRC 258 IKE + +AI L+ + ++ A + YY G ++++ + + L ++ Sbjct: 28 IKEQKFAEAIQHLQYQLQNVPESRAALSLLGYCYYYTGQYDMASQMYEQLVTLYPSNEDY 87 Query: 259 FAHYKQ-VKKLNKLIESAEELIR-DGR--------------YTDATSKYESVMKTEPSIA 302 +Y Q + K E+++ +++ +G D T + K P Sbjct: 88 KLYYAQSLYKGGMYPEASKAVVKVEGHQKAVTTLLVACSYEQDDLTGCRRQLDKCAPEDP 147 Query: 303 EYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQD 362 + V + C E EA R Q D V AL Y E +Y+ A+ Sbjct: 148 DTMVNTG-----CIMFKEGKFEAAR------QKFNDAVQAL-----GYQPELLYNIALCY 191 Query: 363 YETAQEHNENDQQIREGLEKAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWH 422 Y+T Q + + E +EKA R + L V N E+ L+ Sbjct: 192 YKTKQ-FGPALKHLAEIIEKAVRE---------HPELSVGSNTDGMEVRSVGNSQTLK-E 240 Query: 423 PDNFQNEEEKKKAEKKFIDIAAAKEVLSDPEMRKK 457 + K E ++ AAKE L+D R + Sbjct: 241 TALIEAFNLKAAIEYTMKNVEAAKEALTDMPPRAE 275 >5KHR-J nrPDB Length = 620 Score = 38.6 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 17/72 (23%), Positives = 26/72 (36%) Query: 42 ELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLK 101 LG + A+AL A+ P N Y + MG + A+ + L+ Sbjct: 450 NLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLR 509 Query: 102 MDFTAARLQRGH 113 D T + GH Sbjct: 510 RDDTFSVTMLGH 521 >5JZ6-A nrPDB Length = 429 Score = 37.8 bits (86), Expect = 0.010, Method: Composition-based stats. Identities = 31/177 (17%), Positives = 64/177 (36%), Gaps = 48/177 (27%) Query: 37 VEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYY------------RRATVFLA- 83 ++ L+ +KL G++ +A++ F V P + A Y RR+ L Sbjct: 12 IKAELDAAEKLRKRGKIEEAVNAFKELVRKYPQSPRARYGKAQCEDDLAEKRRSNEVLRG 71 Query: 84 --------------------------------MGKSKAALPDLTKVIQLKMDFTAARLQR 111 +G + +L L +++QL + T+ + Sbjct: 72 AIETYQEVASLPDVPADLLKLSLKRRSDRQQFLGHMRGSLLTLQRLVQLFPNDTSLKNDL 131 Query: 112 GHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSG 168 G L G D A+ +++VL P++ K ++K+ Q ++++ G Sbjct: 132 GVGYLLIGDNDNAKKVYEEVLSVTPNDGFAKVHYGFILKA---QNKIAESIPYLKEG 185 Score = 37.8 bits (86), Expect = 0.012, Method: Composition-based stats. Identities = 38/181 (20%), Positives = 77/181 (42%), Gaps = 12/181 (6%) Query: 106 AARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAF 165 A L L K+GK++EA + FK++++ P + ++Q + D ++ RS N Sbjct: 13 KAELDAAEKLRKRGKIEEAVNAFKELVRKYPQSPRARYGKAQC-EDDLAEKRRS---NEV 68 Query: 166 GSGDYTAAIAFLDKILEVCVWDAELREL----RAECFIKEGEPRKAISDLKAASKLKNDN 221 G AI ++ + A+L +L R++ G R ++ L+ +L ++ Sbjct: 69 LRG----AIETYQEVASLPDVPADLLKLSLKRRSDRQQFLGHMRGSLLTLQRLVQLFPND 124 Query: 222 TEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRD 281 T + Y +GD++ + E L + + HY + K I + +++ Sbjct: 125 TSLKNDLGVGYLLIGDNDNAKKVYEEVLSVTPNDGFAKVHYGFILKAQNKIAESIPYLKE 184 Query: 282 G 282 G Sbjct: 185 G 185 >3I5P-A nrPDB Length = 525 Score = 37.4 bits (85), Expect = 0.013, Method: Composition-based stats. Identities = 29/166 (17%), Positives = 64/166 (38%), Gaps = 19/166 (11%) Query: 126 DDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCV 185 D KV + + K I +D+ +LR ++ Y AA+ + D++ + Sbjct: 133 DTLIKVDELAEKKQSSKTQNQISISNDDEVKLRQKS--------YEAALKYNDRLFHYHM 184 Query: 186 WDAELRELRAECFIKEGEP-------RKAISDLKAASKLKNDNTE--AFYKISTLYYQLG 236 +D + + R E + P KA S LK ++ L + F++ + + Y+L Sbjct: 185 YDWLVSQNREEKLLDIETPFILPYLMEKAGSSLKISNILWVYYSRRSKFFESAEILYRLA 244 Query: 237 DHELSLSEVRECLKLDQDHKRC--FAHYKQVKKLNKLIESAEELIR 280 ++ L + + C + Q +++ +L ++ Sbjct: 245 TSNFDITLFERIEFLSRANGFCNSVSPLSQKQRIVQLASRIQDACE 290 >2WZV-A nrPDB Length = 235 Score = 37.0 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 33/143 (23%), Positives = 60/143 (41%), Gaps = 26/143 (18%) Query: 295 MKTEPSI-----AEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEA 349 + T P++ AE ++ + R F DE P E +R E+ P N N + Sbjct: 7 LPTGPTVDLAQAAERLIKGR-RAVRAFRPDEVPEETMRAVFELAGHAPSNSN-----TQP 60 Query: 350 YLIEEMYDEAIQDYETA--QEHNEN----DQQIREGLEKAQRLLKQSQKRDY----YKIL 399 + +E + A A H E D REGL + + Q ++ D+ Y L Sbjct: 61 WHVEVVSGAARDRLAEALVTAHAEERVTVDFPYREGLF---QGVLQERRADFGSRLYAAL 117 Query: 400 GVKRNAKKQEIIKAYRKLALQWH 422 G+ R + ++++ Y +L+++ Sbjct: 118 GIAR--DQTDLLQGYNTESLRFY 138 >3UO2-A nrPDB Length = 175 Score = 37.0 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 15/55 (27%), Positives = 22/55 (40%), Gaps = 6/55 (10%) Query: 404 NAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDPEMRKKF 458 + + K YR+L Q HPD Q E+ + A L DP R ++ Sbjct: 21 TIDQSRLRKEYRQLQAQHHPDMAQQGSEQSST------LNQAYHTLKDPLRRSQY 69 >4JHR-A nrPDB Length = 333 Score = 36.3 bits (82), Expect = 0.030, Method: Composition-based stats. Identities = 45/259 (17%), Positives = 82/259 (31%), Gaps = 45/259 (17%) Query: 36 DVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYI------AYYRRATVFLAMGKSKA 89 + + LG L G +A+ +D + A Y V+ A GKS Sbjct: 10 EAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFG 69 Query: 90 ----------------ALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLK 133 AL + + + A R G L L Sbjct: 70 CPGPQDTGEFPEDVRNALQAAVDLYEENLSLVTALGDRAAQGRAFGNLGNTH-----YLL 124 Query: 134 SNPSENEEKEAQSQLIKSDEMQR-LRSQALNAFGS-----GDYTAAIAFLDKILEVC--- 184 N + Q LI + + +A + G+ G++ A + K L + Sbjct: 125 GNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQL 184 Query: 185 ---VWDAELRELRAECFIKEGEPRKAI----SDLKAASKLKNDNTE--AFYKISTLYYQL 235 +A+ + + KAI L A +LK+ E A + + Y L Sbjct: 185 KDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELKDRIGEGRACWSLGNAYTAL 244 Query: 236 GDHELSLSEVRECLKLDQD 254 G+H+ ++ + L++ ++ Sbjct: 245 GNHDQAMHFAEKHLEISRE 263 >4F3X-A nrPDB Length = 498 Score = 36.3 bits (82), Expect = 0.035, Method: Composition-based stats. Identities = 22/115 (19%), Positives = 34/115 (29%), Gaps = 18/115 (15%) Query: 22 VDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVF 81 VDL E D + L +G + A + + + +P A Sbjct: 11 VDLGTENLYFQSMMDTQ--LLIGSRFEAGTEAEEHI--------LNPRTGAGIIDLAEAS 60 Query: 82 LAMGKSK--AALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKS 134 A + AA Q +R + LLK E E D L++ Sbjct: 61 HAQIDAAVDAAERAFVGWSQTTP------AERSNALLKIADAIEKEADEFAALEA 109 >6G70-A nrPDB Length = 670 Score = 35.5 bits (80), Expect = 0.058, Method: Composition-based stats. Identities = 51/334 (15%), Positives = 107/334 (32%), Gaps = 40/334 (11%) Query: 164 AFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTE 223 +G + + ++ + C L E +IK + + S T Sbjct: 366 EIENGTHERVVVLFERCVISC-------ALYEEFWIKYAKYMENHSIEGVRHVFSRACTV 418 Query: 224 AFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGR 283 K + E + E + + + C V+ +E R G Sbjct: 419 HLPKKPMAHMLWAAFEEQQGNINEARIILRTFEECVLGLAMVRLRRVSLER-----RHGN 473 Query: 284 YTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNAL 343 +A + +K S E + + + H F + ++ +V E ++ + +N Sbjct: 474 MEEAEHLLQDAIKNAKSNNESSFYAIKLARHLFKIQKNLPKSRKVLLEAIEKDKENTKLY 533 Query: 344 KDRAEAYLIEEMYDEAIQDYETAQEHNEN--DQQIREGLEKAQRLLKQSQKRDYYKILGV 401 + L+E Y D + +E+ N D+ I L R+ +K ++ + G Sbjct: 534 LN-----LLEMEYS---CDLKQNEENILNCFDKAIHGSLPIKMRITFSQRKVEFLEDFG- 584 Query: 402 KRNAKKQEIIKAY-RKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDPEMRKKFDD 460 + +++ AY L D + + E E K+ ++ + D Sbjct: 585 ---SDVNKLLNAYDEHQTLLKEQDTLKRKAENGSEEP------EEKKAHTEDLSSAQIID 635 Query: 461 GEDPLDAESQQGGGGNPFHRSWNSWQGFNPFSSG 494 G Q + +W + NP++ G Sbjct: 636 G-------DLQANQAAYNYSAWYQYNYQNPWNYG 662 >5WRW-A nrPDB Length = 163 Score = 35.1 bits (79), Expect = 0.065, Method: Composition-based stats. Identities = 25/126 (19%), Positives = 62/126 (49%), Gaps = 3/126 (2%) Query: 162 LNAFGS-GDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKND 220 +N +G GD+T A+ ++KIL++ D + C I+ G ++A++ + +K+ + Sbjct: 18 VNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLAN 77 Query: 221 NTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAH-YKQVKKLNKLIESAEELI 279 N+ +F K + Y+L E +L + + K + ++++ ++ + +L+ Sbjct: 78 NSLSFEK-AYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLV 136 Query: 280 RDGRYT 285 R+ + Sbjct: 137 RNSQDD 142 >3HVU-A nrPDB Length = 204 Score = 35.1 bits (79), Expect = 0.071, Method: Composition-based stats. Identities = 30/110 (27%), Positives = 51/110 (46%), Gaps = 16/110 (14%) Query: 22 VDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVF 81 VDL E NA + + +E K L++ Q+ + + + A + D N TV Sbjct: 11 VDLGTENLYFQSNAMMNQDIE--KVLISEEQIQEKVLELGAIIAEDYKN--------TVP 60 Query: 82 LAMGKSKAALPDLTKVIQ-----LKMDFTAARLQRGHLLLKQGKLDEAED 126 LA+G K A+P + +++ L+MDF A GH + G++ +D Sbjct: 61 LAIGVLKGAMPFMADLLKRTDTYLEMDFMAV-SSYGHSTVSTGEVKILKD 109 >5OJF-A nrPDB Length = 314 Score = 34.7 bits (78), Expect = 0.083, Method: Composition-based stats. Identities = 35/187 (18%), Positives = 62/187 (33%), Gaps = 21/187 (11%) Query: 42 ELGKKLLAAGQLADALSQFHAAVDG--------DPDNYIAYYRRATVFLAMGKSKAALPD 93 L + + G+ A+ A++ PD A V+ K K A Sbjct: 33 NLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAAHL 92 Query: 94 LTKVIQLK--------MDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPS--ENEEKE 143 L + ++ A L K+GK EAE K+ L+ + Sbjct: 93 LNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPD 152 Query: 144 AQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWD-AELRELRAECFIKEG 202 QL S+ ++Q Y A+ L + A+ + A C++K+G Sbjct: 153 VAKQL--SNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQG 210 Query: 203 EPRKAIS 209 + + A + Sbjct: 211 KYQDAET 217 >2PF4-E nrPDB Length = 174 Score = 34.7 bits (78), Expect = 0.093, Method: Composition-based stats. Identities = 22/87 (25%), Positives = 39/87 (44%), Gaps = 4/87 (4%) Query: 398 ILGVKRNA--KKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDPEMR 455 +LG++R+A + KAY K ++HPD +EE+ KK + + + P+ Sbjct: 16 LLGLERSAWGNIPLMRKAYLKKCKEFHPDKGGDEEKMKKMNTLYKKMEDGVKYAHQPDFG 75 Query: 456 KKFDDGEDPLDAESQQGGGGNPFHRSW 482 +D E + A S G + + W Sbjct: 76 GFWDATE--VFASSLNPGVDAIYCKQW 100 >4GYO-A nrPDB Length = 373 Score = 34.7 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 47/258 (18%), Positives = 86/258 (33%), Gaps = 18/258 (6%) Query: 111 RGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDY 170 RG KQ A D +K + +E E L K E+ Q F Sbjct: 105 RGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQ--TYFSMNYA 162 Query: 171 TAAIAFLDK----ILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDN--TEA 224 + A+ K + + + + E S L+ A +L+ A Sbjct: 163 SQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYMIAAA 222 Query: 225 FYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRY 284 +Y + Y LGD++ + + + F + + + + ++G+Y Sbjct: 223 YYNVGHCKYSLGDYKEAEGYFKTAAAI-------FEEHNFQQAVQAVFSLTHIYCKEGKY 275 Query: 285 TDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVC---SEVLQMEPDNVN 341 A Y+ +K+ + +K R+ H + + C E Q+ D + Sbjct: 276 DKAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAED 335 Query: 342 ALKDRAEAYLIEEMYDEA 359 L D AE + E Y+ A Sbjct: 336 LLHDTAERFNQLEHYESA 353 Score = 30.5 bits (67), Expect = 1.7, Method: Composition-based stats. Identities = 30/170 (17%), Positives = 49/170 (28%), Gaps = 17/170 (10%) Query: 19 LVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHA----AVDGDPDNYIAY 74 L V+ + E AE E + + + + + AL + +I Sbjct: 129 LEYVEDEIEKAEFLFKV-AEVYYHIKQTYFSMNYASQALDIYTKYELYGRRRVQCEFIIA 187 Query: 75 YRRATVFLAMGKSKAALPDLTKVIQLKMDF--TAARLQRGHLLLKQGKLDEAEDDFKKVL 132 V+ L QL+ + AA GH G EAE FK Sbjct: 188 GNLTDVYHHEKALTHLCSALEHARQLEEAYMIAAAYYNVGHCKYSLGDYKEAEGYFKTAA 247 Query: 133 KSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILE 182 N ++ Q+ S G Y A+ D+ ++ Sbjct: 248 AIFEEHNFQQAVQAVF----------SLTHIYCKEGKYDKAVEAYDRGIK 287 >3N2B-A nrPDB Length = 441 Score = 34.3 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 43/157 (27%), Positives = 59/157 (37%), Gaps = 22/157 (14%) Query: 22 VDLQYEGAECGVNA-DVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATV 80 VDL E NA D + E G+ LAD +Q+ G P + Sbjct: 11 VDLGTENLYFQSNAMDYFNYQEDGQLWAEQVPLADLANQY-----GTPLYVYSRATLERH 65 Query: 81 FLAMGKSKAALPDLT-KVIQLKMDF----TAARLQRGHLLLKQGKLDE---AEDDFKKVL 132 + A KS P L ++ + T ARL G ++ G+L+ A D KV+ Sbjct: 66 WHAFDKSVGDYPHLICYAVKANSNLGVLNTLARLGSGFDIVSVGELERVLAAGGDPSKVV 125 Query: 133 KS--NPSENEEKEAQSQLIK------SDEMQRLRSQA 161 S +E E K A IK E+QRL A Sbjct: 126 FSGVGKTEAEMKRALQLKIKCFNVESEPELQRLNKVA 162 >6FRK-r nrPDB Length = 605 Score = 34.3 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 25/126 (19%), Positives = 62/126 (49%), Gaps = 3/126 (2%) Query: 162 LNAFGS-GDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKND 220 +N +G GD+T A+ ++KIL++ D + C I+ G ++A++ + +K+ + Sbjct: 18 VNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLAN 77 Query: 221 NTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAH-YKQVKKLNKLIESAEELI 279 N+ +F K + Y+L E +L + + K + ++++ ++ + +L+ Sbjct: 78 NSLSFEK-AYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLV 136 Query: 280 RDGRYT 285 R+ + Sbjct: 137 RNSQDD 142 Score = 32.8 bits (73), Expect = 0.36, Method: Composition-based stats. Identities = 75/412 (18%), Positives = 137/412 (33%), Gaps = 79/412 (19%) Query: 36 DVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLT 95 D E+ L + A + + + + Y A + G+ A+ L Sbjct: 144 DEERKTNLSAVVAAQSNWEKVVPE---NLGLQEGTHELCYNAACALIGQGQLSQAMKILQ 200 Query: 96 KVIQLKM----------------DFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSE- 138 K L + Q ++L QG+ +EA + +++K P++ Sbjct: 201 KAEDLCRRSLSEDSDGTEEDPQAELAIIHGQMAYILQLQGRTEEALQLYNQIIKLKPTDV 260 Query: 139 --------NEEKEAQSQ-LIKSDEMQRLRSQALNAFG-SGDYTAAIAFLDKILEVCVWDA 188 N + Q + S + +L + F S AI F +L + A Sbjct: 261 GLLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQA 320 Query: 189 ELRELRAECFIKEGEPRKAISDLKAASKL--KNDNTEAFYKISTLYYQLGDHELSLSEVR 246 E + + ++ P + L A++L + +T+A I L H + +E++ Sbjct: 321 E-QCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKA---IELLQEFSDQHPENAAEIK 376 Query: 247 EC---LKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAE 303 LK+ Q + + K ++ S EEL K +P + Sbjct: 377 LTMAQLKISQGN---------ISKACLILRSIEEL-----------------KHKPGMVS 410 Query: 304 YTVRSKERICHCFSKDEKPVEAIRVCSEVLQM----EPDNVNALKDRAEAYLIEEMY--- 356 V +S +E AI V ++ +Q +P + L EA + Y Sbjct: 411 ALVT-------MYSHEEDIDSAIEVFTQAIQWYQNHQPKSSAHLSLIREAANFKLKYGRK 463 Query: 357 DEAIQDYETAQEHNENDQQIREGLEKAQRLLKQSQKRDYYKILGVKRNAKKQ 408 EAI D E + N D L A L+ + + K L + + Sbjct: 464 KEAISDLEQLWKQNPKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLK 515 >5EFR-A nrPDB Length = 446 Score = 34.0 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 46/254 (18%), Positives = 91/254 (35%), Gaps = 49/254 (19%) Query: 149 IKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILE---VCVWDAELRELRAECFIKEGEPR 205 ++ Q +A+ + G Y AI + + W A+ + A + + E Sbjct: 195 LRHSSPQEAFERAMEFYNQGKYDRAIEYFKAVFTYGRTHEWAADAQFYLARAYYQNKEYL 254 Query: 206 KAISDLK---AASKLKNDNTEAFYKISTLYYQLG--------DHELSLSEVRECLKLDQD 254 A S+ + ++ +A Y+ + YY+L D ++ + + + Sbjct: 255 LAASEYERFIQIYQIDPRVPQAEYERAMCYYKLSPPYELDQTDTRKAIEAFQLFIDRYPN 314 Query: 255 HKRCFAHYKQVKKL-----NKLIESAEELIRDGRYTDATSKYESVMKTEP---------- 299 H+ +++++L K E+A R Y A YE+V P Sbjct: 315 HELVDDATQKIRELRAKLARKQYEAARLYERRELYEAAAVTYEAVFDAYPDTPWADDALV 374 Query: 300 -------SIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDN-----VNALKDRA 347 + AE +VR+++ E+ A+ + +LQ+ PD+ L RA Sbjct: 375 GAMRAYIAYAEQSVRARQ--------PERYRRAVELYERLLQIFPDSPLLRTAEELYTRA 426 Query: 348 EAYLIEEMYDEAIQ 361 L E D ++ Sbjct: 427 RQRLTELEGDASLA 440 >5OJ8-A nrPDB Length = 255 Score = 34.0 bits (76), Expect = 0.17, Method: Composition-based stats. Identities = 27/156 (17%), Positives = 49/156 (31%), Gaps = 22/156 (14%) Query: 34 NADVEKHLE-LGKKLLAAGQLADALSQFHAAVDGD--------PDNYIAYYRRATVFLAM 84 + DV L L + DA + + A+ P A ++ Sbjct: 88 HPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKR 147 Query: 85 GKSKAALPDLTKVIQLK--------MDFTAARLQRGHLLLKQGKLDEAEDDFKKVLK--- 133 GK K A P + ++++ D L QGK +E E +++ L+ Sbjct: 148 GKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQ 207 Query: 134 --SNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGS 167 P + + ++ L Q QA + Sbjct: 208 TKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKE 243 >5UDI-A nrPDB Length = 479 Score = 33.6 bits (75), Expect = 0.19, Method: Composition-based stats. Identities = 39/230 (16%), Positives = 76/230 (33%), Gaps = 44/230 (19%) Query: 53 LADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPD--------LTKVIQLKMDF 104 A + F ++ DP+N + A + K A + L + ++L D Sbjct: 158 YERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNHKPFSLLPLRQAVRLNPDN 217 Query: 105 TAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNA 164 ++ L +G+ E E ++ L + S+ ++ + Sbjct: 218 GYIKVLLALKLQDEGQEAEGEKYIEEALANMSSQTYVFRYAAKFYR-------------- 263 Query: 165 FGSGDYTAAIAFLDKILEVCVWDAELRELRAECF------IKE---GEP----------- 204 G A+ L K L+ L C+ IKE G+P Sbjct: 264 -RKGSVDKALELLKKALQETPTSVLLHHQIGLCYKAQMIQIKEATKGQPRGQNREKLDKM 322 Query: 205 -RKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQ 253 R AI ++A + K A ++ +Y + G+H + ++ L + Sbjct: 323 IRSAIFHFESAVEKKPTFEVAHLDLARMYIEAGNHRKAEENFQKLLCMKP 372 Score = 33.2 bits (74), Expect = 0.31, Method: Composition-based stats. Identities = 37/183 (20%), Positives = 63/183 (34%), Gaps = 17/183 (9%) Query: 118 QGKLDEAEDDFKKVLKSNPSENEEKEAQSQL---IKSDEMQRLRSQALNAFGSGDYTAAI 174 G+L EA+ KV EN K+ + ++ E+ AL G +Y A Sbjct: 109 MGRLAEAQTYLDKV------ENICKKLSNPFRYRMECPEIDCEEGWALLKCGGKNYERAK 162 Query: 175 AFLDKILEVCVWDAELRELRAECFIKEGEPRKAISD--------LKAASKLKNDNTEAFY 226 A +K+LEV + E A + + A + L+ A +L DN Sbjct: 163 ACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNHKPFSLLPLRQAVRLNPDNGYIKV 222 Query: 227 KISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTD 286 ++ G + E L F + + + ++ A EL++ Sbjct: 223 LLALKLQDEGQEAEGEKYIEEALANMSSQTYVFRYAAKFYRRKGSVDKALELLKKALQET 282 Query: 287 ATS 289 TS Sbjct: 283 PTS 285 >4PFR-A nrPDB Length = 331 Score = 33.6 bits (75), Expect = 0.23, Method: Composition-based stats. Identities = 17/90 (18%), Positives = 27/90 (30%), Gaps = 8/90 (8%) Query: 22 VDLQYEGAECGVNADVEKHLELGK-----KLLAAGQLADALSQFHAA---VDGDPDNYIA 73 VDL E D L G L A + + + ++ V P N + Sbjct: 11 VDLGTENLYFQSMQDYTIRLSHGDNESNPTHLTAVKFQELVKEYTEGKAEVQIFPSNSLG 70 Query: 74 YYRRATVFLAMGKSKAALPDLTKVIQLKMD 103 L MG +A + ++ L Sbjct: 71 TETEVAQALRMGSIEAEILYTGNLVPLAPS 100 >3QDN-A nrPDB Length = 287 Score = 33.2 bits (74), Expect = 0.24, Method: Composition-based stats. Identities = 26/98 (26%), Positives = 45/98 (45%), Gaps = 4/98 (4%) Query: 160 QALNAFGSGDYTAAI-AFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLK 218 Q ++ F AI A LDK+L + EL+ +A ++EG A+ LK A +L Sbjct: 91 QPVDGFQGPQPEEAIRALLDKVLPR---EEELKAQQAMQLMQEGNYIDALPLLKDAWQLS 147 Query: 219 NDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHK 256 + N+E ++ L E + + ++ DQD + Sbjct: 148 SQNSEIGLLLAEAQIALNRSEEAEAVLKTIPLQDQDTR 185 Score = 31.7 bits (70), Expect = 0.87, Method: Composition-based stats. Identities = 16/68 (23%), Positives = 27/68 (39%) Query: 153 EMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLK 212 E + QA+ G+Y A+ L ++ ++E+ L AE I +A + LK Sbjct: 116 EEELKAQQAMQLMQEGNYIDALPLLKDAWQLSSQNSEIGLLLAEAQIALNRSEEAEAVLK 175 Query: 213 AASKLKND 220 D Sbjct: 176 TIPLQDQD 183 >3NF1-A nrPDB Length = 311 Score = 33.2 bits (74), Expect = 0.26, Method: Composition-based stats. Identities = 27/156 (17%), Positives = 49/156 (31%), Gaps = 22/156 (14%) Query: 34 NADVEKHLE-LGKKLLAAGQLADALSQFHAAVDGD--------PDNYIAYYRRATVFLAM 84 + DV L L + DA + + A+ P A ++ Sbjct: 65 HPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKR 124 Query: 85 GKSKAALPDLTKVIQLK--------MDFTAARLQRGHLLLKQGKLDEAEDDFKKVLK--- 133 GK K A P + ++++ D L QGK +E E +++ L+ Sbjct: 125 GKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQ 184 Query: 134 --SNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGS 167 P + + ++ L Q QA + Sbjct: 185 TKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKE 220 >3BVO-A nrPDB Length = 207 Score = 33.2 bits (74), Expect = 0.26, Method: Composition-based stats. Identities = 17/80 (21%), Positives = 35/80 (43%), Gaps = 4/80 (5%) Query: 391 QKRDYYKILGVKRN--AKKQEIIKAYRKLALQWHPD--NFQNEEEKKKAEKKFIDIAAAK 446 RDY+ ++ R+ ++ Y++L HPD + +++ EK +EK + A Sbjct: 41 PTRDYFSLMDCNRSFRVDTAKLQHRYQQLQRLVHPDFFSQRSQTEKDFSEKHSTLVNDAY 100 Query: 447 EVLSDPEMRKKFDDGEDPLD 466 + L P R + ++ Sbjct: 101 KTLLAPLSRGLYLLKLHGIE 120 >6CNF-R nrPDB Length = 736 Score = 33.2 bits (74), Expect = 0.28, Method: Composition-based stats. Identities = 34/133 (25%), Positives = 51/133 (38%), Gaps = 7/133 (5%) Query: 139 NEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECF 198 N + + S + Q LN F + AA + K E V D E R F Sbjct: 236 NLRRTHTEIVAVSHVAEETLQQRLNEFKNTK--AAKLSVQKFRENDVEDG---EARPPSF 290 Query: 199 IKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRC 258 +K + + I D ++ + EA K L LG+ ELS EV L Q +R Sbjct: 291 VKNRKKERKIKDSLDKEEMFQTSEEALNKNPILTQVLGEQELSSKEV--LFYLKQFSERR 348 Query: 259 FAHYKQVKKLNKL 271 +++K N + Sbjct: 349 ARVVERIKATNGI 361 >1HH8-A nrPDB Length = 213 Score = 33.2 bits (74), Expect = 0.30, Method: Composition-based stats. Identities = 9/51 (17%), Positives = 24/51 (47%) Query: 206 KAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHK 256 +A + A+++ LYYQ ++L++ +++E L + ++ Sbjct: 55 EAEKAFTRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQ 105 >5AEM-A nrPDB Length = 447 Score = 32.8 bits (73), Expect = 0.38, Method: Composition-based stats. Identities = 57/348 (16%), Positives = 126/348 (36%), Gaps = 35/348 (10%) Query: 55 DALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHL 114 A+ F + +P + + YRR+ ++ G+ AL ++ + L Sbjct: 95 QAIYCFSRVISLNPMEWESIYRRSMLYKKTGQLARALDGFQRLYMYNPYDANILRELAIL 154 Query: 115 LLKQGKLDEAEDDFKKVLKSNPS-------------ENEEKEAQSQLIKSDEMQRLRSQA 161 + +++++ + + KV +N ++ ++E+ ++ +DE + L Sbjct: 155 YVDYDRIEDSIELYMKVFNANVERREAILAALENALDSSDEESAAEGEDADEKEPLEQDE 214 Query: 162 LNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPR----KAISDLKAASKL 217 I K + W + + AE F+K K I A + Sbjct: 215 DRQMFPDINWKKIDAKYKCIPFD-WSSL--NILAELFLKLAVSEVDGIKTIKKC--ARWI 269 Query: 218 KNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEE 277 + ++ F+ + + S L +++ +V +L L + + Sbjct: 270 QRRESQTFWDHVPDDSEFDNRRFKNSTFDSLLAAEKEKSYNIPIDIRV-RLGLLRLNTDN 328 Query: 278 LIRDGRYTDATSKYESVM-KTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQME 336 L+ A + ++ + +T +A+ + + ++ EK EAI + +L +E Sbjct: 329 LVE------ALNHFQCLYDETFSDVADLYFEAATAL----TRAEKYKEAIDFFTPLLSLE 378 Query: 337 P-DNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKA 383 + K A Y E Y+ A + YE A + +D IR L + Sbjct: 379 EWRTTDVFKPLARCYKEIESYETAKEFYELAIKSEPDDLDIRVSLAEV 426 Score = 30.9 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 16/101 (15%), Positives = 38/101 (37%), Gaps = 7/101 (6%) Query: 47 LLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTA 106 GQLA AL F +P + A +++ + + ++ KV ++ Sbjct: 121 YKKTGQLARALDGFQRLYMYNPYDANILRELAILYVDYDRIEDSIELYMKVFNANVE--- 177 Query: 107 ARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQ 147 +R +L ++ D+ + + ++ +E Q + Sbjct: 178 ---RREAILAALENALDSSDE-ESAAEGEDADEKEPLEQDE 214 Score = 29.0 bits (63), Expect = 5.1, Method: Composition-based stats. Identities = 9/59 (15%), Positives = 21/59 (35%) Query: 43 LGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLK 101 L + A + A+ +PD+ A V+ + + L V++++ Sbjct: 389 LARCYKEIESYETAKEFYELAIKSEPDDLDIRVSLAEVYYRLNDPETFKHMLVDVVEMR 447 >4Q0N-A nrPDB Length = 145 Score = 32.8 bits (73), Expect = 0.38, Method: Composition-based stats. Identities = 26/129 (20%), Positives = 44/129 (34%), Gaps = 13/129 (10%) Query: 22 VDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVF 81 VDL E + + KK + L++ + AV + RR + Sbjct: 11 VDLGTENLYFQSMSGISP-----KKSKYMTPMQQKLNEVYEAVK---NYTDKRGRRLSAI 62 Query: 82 LAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEE 141 S++ LPD I+ MD R + K +D +DF + + Sbjct: 63 FLRLPSRSELPDYYLTIKKPMDMEKIRSHM--MANKYQDIDSMVEDFVMMFN---NACTY 117 Query: 142 KEAQSQLIK 150 E +S + K Sbjct: 118 NEPESLIYK 126 >3ZFW-A nrPDB Length = 263 Score = 32.4 bits (72), Expect = 0.45, Method: Composition-based stats. Identities = 31/153 (20%), Positives = 52/153 (33%), Gaps = 13/153 (8%) Query: 68 PDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLK--------MDFTAARLQRGHLLLKQG 119 PD A V+ K K A L + ++ A L K+G Sbjct: 20 PDVATMLNILALVYRDQNKYKDAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRG 79 Query: 120 KLDEAEDDFKKVLKSNPS--ENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFL 177 K EAE K+ L+ + QL S+ ++Q Y A+ Sbjct: 80 KYKEAEPLCKRALEIREKVLGKFHPDVAKQL--SNLALLCQNQGKAEEVEYYYRRALEIY 137 Query: 178 DKILEVCVWD-AELRELRAECFIKEGEPRKAIS 209 L + A+ + A C++K+G+ + A + Sbjct: 138 ATRLGPDDPNVAKTKNNLASCYLKQGKYQDAET 170 >1F6F-A nrPDB Length = 199 Score = 32.4 bits (72), Expect = 0.47, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 30/68 (44%), Gaps = 3/68 (4%) Query: 363 YETAQEHNENDQQIREGLEKAQRLLKQSQKRDYYKILGVKRNAKKQE---IIKAYRKLAL 419 AQE E + + +G+E Q+ + +K + Y + + + Q+ A+ +L Sbjct: 115 LTKAQEIKEKAKVLVDGVEVIQKRIHPGEKNEPYPVWSEQSSLTSQDENVRRVAFYRLFH 174 Query: 420 QWHPDNFQ 427 H D+ + Sbjct: 175 CLHRDSSK 182 >6F41-V nrPDB Length = 596 Score = 32.4 bits (72), Expect = 0.52, Method: Composition-based stats. Identities = 39/162 (24%), Positives = 62/162 (38%), Gaps = 13/162 (8%) Query: 139 NEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECF 198 N + + S + Q LN F + AA + K E V D E R F Sbjct: 236 NLRRTHTEIVAVSHVAEETLQQRLNEFKNTK--AAKLSVQKFRENDVEDG---EARPPSF 290 Query: 199 IKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRC 258 +K + + I D ++ + EA K L LG+ ELS EV L Q +R Sbjct: 291 VKNRKKERKIKDSLDKEEMFQTSEEALNKNPILTQVLGEQELSSKEV--LFYLKQFSERR 348 Query: 259 FAHYKQVKKLNKLI------ESAEELIRDGRYTDATSKYESV 294 +++K N + E +E R + ++ + + E V Sbjct: 349 ARVVERIKATNGIDGENIYHEGSENETRKRKLSEVSIQNEHV 390 >4E69-A nrPDB Length = 328 Score = 32.4 bits (72), Expect = 0.53, Method: Composition-based stats. Identities = 24/115 (20%), Positives = 39/115 (33%), Gaps = 13/115 (11%) Query: 22 VDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVF 81 VDL E + L +G+ + AD + GD N Y R Sbjct: 11 VDLGTENLYFQSMMHI---LSIGECMAELAP-ADLPGTYRLGFAGDTFNTAWYLARLRPE 66 Query: 82 LAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGK--------LDEAEDDF 128 + A+ D Q++ +AA + G L + G+ L++ E F Sbjct: 67 SRISYFS-AIGDDALSQQMRAAMSAAGIDGGGLRVIPGRTVGLYLITLEQGERSF 120 >3LM0-A nrPDB Length = 327 Score = 32.0 bits (71), Expect = 0.55, Method: Composition-based stats. Identities = 9/42 (21%), Positives = 12/42 (28%) Query: 22 VDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAA 63 VDL E + L K L G+ A + Sbjct: 11 VDLGTENLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKS 52 >2DB3-A nrPDB Length = 434 Score = 32.0 bits (71), Expect = 0.55, Method: Composition-based stats. Identities = 27/96 (28%), Positives = 42/96 (43%), Gaps = 1/96 (1%) Query: 80 VFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSEN 139 VF+A+G A D+ + I +++ A R + +L +Q + K+ S Sbjct: 262 VFVAIGIVGGACSDVKQTI-YEVNKYAKRSKLIEILSEQADGTIVFVETKRGADFLASFL 320 Query: 140 EEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIA 175 EKE + I D +Q R QAL F +G IA Sbjct: 321 SEKEFPTTSIHGDRLQSQREQALRDFKNGSMKVLIA 356 >2C7S-A nrPDB Length = 313 Score = 32.0 bits (71), Expect = 0.60, Method: Composition-based stats. Identities = 24/127 (18%), Positives = 42/127 (33%), Gaps = 11/127 (8%) Query: 22 VDLQYEGAECGVN-----ADVEKHLELGKKLLAAG---QLADALSQFHAAVDGDPDNYIA 73 VDL E AD+ +H+ L K + G + A+ D + Sbjct: 11 VDLGTENLYFQSMPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNR 70 Query: 74 YYRRATVFLAMGKSKAALP---DLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKK 130 R +A S+ L D + ++ + H + QG + E DF + Sbjct: 71 AKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWR 130 Query: 131 VLKSNPS 137 ++ S Sbjct: 131 MIWQEQS 137 >4JOS-A nrPDB Length = 250 Score = 32.0 bits (71), Expect = 0.64, Method: Composition-based stats. Identities = 16/80 (20%), Positives = 27/80 (33%), Gaps = 3/80 (3%) Query: 22 VDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVF 81 VDL E +K LG + + L ++ + Y+A Y + Sbjct: 11 VDLGTENLYFQSM---KKIAILGAMEIEIQPILQKLEKYETVEYANNKYYVANYNGIELV 67 Query: 82 LAMGKSKAALPDLTKVIQLK 101 +A K LT I ++ Sbjct: 68 VAYSKIGKVFSSLTATIMIE 87 >3UHP-A nrPDB Length = 274 Score = 32.0 bits (71), Expect = 0.66, Method: Composition-based stats. Identities = 52/277 (18%), Positives = 79/277 (28%), Gaps = 30/277 (10%) Query: 22 VDLQYEGAECGVNA--------DVEKHLELGKKLLAAGQLADALSQFHAAVDG-----DP 68 VDL E NA V L A L D + + D Sbjct: 11 VDLGTENLYFQSNAMKIGVFDSGVGGLSVLKSLYEAR--LFDEIIYYGDTARVPYGVKDK 68 Query: 69 DNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDF 128 D I + A F + + +D A+ G +D + Sbjct: 69 DTIIKFCLEALDFFEQFQIDMLIIACNTASAYALDALRAKAH----FPVYGVIDAGVEAT 124 Query: 129 KKVLKSNPSENEEKEAQSQLIKSDEMQ-RLRSQA---LNAFGSGDYTAAIAFLDKILEVC 184 K L + ++ A IKS+E Q RL SQ +NA +G + + + I E Sbjct: 125 IKALH-DKNKEILVIATKATIKSEEYQKRLLSQGYTNINALATGLFVPMVE--EGIFEGD 181 Query: 185 VWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSE 244 L+ F P I L ++ F + L + L E Sbjct: 182 ----FLQSAMEYYFKNITTPDALILACTHFPLLGRSLSKYFGDKTKLIHSGDAIVEFLKE 237 Query: 245 VRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRD 281 + K F V+ L + L+R Sbjct: 238 RENIDLKNHKAKLHFYASSDVESLKNTAKIWLNLLRK 274 >4HOU-A nrPDB Length = 273 Score = 31.7 bits (70), Expect = 0.70, Method: Composition-based stats. Identities = 35/176 (19%), Positives = 61/176 (34%), Gaps = 17/176 (9%) Query: 118 QGKLDEAEDDFKKVLKSNPSENEEKEAQSQL---IKSDEMQRLRSQALNAFGSGDYTAAI 174 G+L EA+ KV EN K+ + ++ E+ AL G +Y A Sbjct: 102 MGRLAEAQTYLDKV------ENICKKLSNPFRYRMECPEIDCEEGWALLKCGGKNYERAK 155 Query: 175 AFLDKILEVCVWDAELRELRAECFIKEGEPRKAISD--------LKAASKLKNDNTEAFY 226 A +K+LEV + E A + + A + L+ A +L DN Sbjct: 156 ACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNHKPFSLLPLRQAVRLNPDNGYIKV 215 Query: 227 KISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDG 282 ++ G + E L F + + + ++ A EL++ Sbjct: 216 LLALKLQDEGQEAEGEKYIEEALANMSSQTYVFRYAAKFYRRKGSVDKALELLKKA 271 >2JIS-A nrPDB Length = 515 Score = 31.7 bits (70), Expect = 0.81, Method: Composition-based stats. Identities = 7/18 (38%), Positives = 7/18 (38%) Query: 22 VDLQYEGAECGVNADVEK 39 VDL E AD E Sbjct: 11 VDLGTENLYFQSMADSEA 28 >1XMD-A nrPDB Length = 612 Score = 31.3 bits (69), Expect = 0.93, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 22/50 (44%), Gaps = 1/50 (2%) Query: 121 LDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLR-SQALNAFGSGD 169 L+E+ + + +K +E+E K+ + + K E R Q L G Sbjct: 28 LEESLKKYLESVKPFANEDEYKKTEEIVQKFQEGAGKRLHQKLLERARGK 77 >5B8H-A nrPDB Length = 290 Score = 31.3 bits (69), Expect = 0.99, Method: Composition-based stats. Identities = 26/101 (25%), Positives = 32/101 (31%), Gaps = 13/101 (12%) Query: 22 VDLQYEGAECGVNADVEKHLEL--GKKLLAAGQLADA------LSQFHAAVDG--DPDNY 71 VDL E NA E HL + G + LADA F DG DPD Sbjct: 11 VDLGTENLYFQSNAMSEPHLLIDAGNSRIKWA-LADARRTLVDTGAFGHTRDGGADPDWS 69 Query: 72 IAYYRRATVF--LAMGKSKAALPDLTKVIQLKMDFTAARLQ 110 R +A A + L + T R + Sbjct: 70 RLPRPRGAWISNVAGADVAARIDALLDARWPGLPRTTIRSR 110 >3J98-H nrPDB Length = 297 Score = 30.9 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 47/272 (17%), Positives = 100/272 (36%), Gaps = 32/272 (11%) Query: 52 QLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQR 111 ++ +A + A + ++ A + A G + L +Q K D + Sbjct: 39 KIEEACEIYARAANM--------FKMAKNWSAAGNAFCQAAQLHLQLQSKHDAATCFVDA 90 Query: 112 GHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLR----SQALNAF-G 166 G+ K+ EA + + ++ A I E+ +A+ + Sbjct: 91 GNA-FKKADPQEAINCLMRAIEIYTDMGRFTIAAKHHISIAEIYETELVDVEKAIAHYEQ 149 Query: 167 SGDYTAAIAFLDK----ILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNT 222 S DY +L+V + A+L + + I + + + LK Sbjct: 150 SADYYKGEESNSSANKCLLKVAGYAAQLEQYQKAIDI----YEQVGTSAMDSPLLKYSAK 205 Query: 223 EAFYKISTLYYQLGDHE--LSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIR 280 + F+K + ++ + L++ + E D + C K + KL+E+ EE Sbjct: 206 DYFFKAALCHFCIDMLNAKLAVQKYEELFPAFSDSREC-------KLMKKLLEAHEEQNV 258 Query: 281 DGRYTDATSKYESVMKTEPSIAEYTVRSKERI 312 D YT++ +Y+S+ + + + +R K+ I Sbjct: 259 DS-YTESVKEYDSISRLDQWLTTMLLRIKKTI 289 >4HY3-A nrPDB Length = 365 Score = 30.9 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 22/58 (37%), Gaps = 6/58 (10%) Query: 22 VDLQYEGAECGVNADVEKHLELGK------KLLAAGQLADALSQFHAAVDGDPDNYIA 73 VDL E + E+ L + L+ + + AL + V+ DP+N Sbjct: 11 VDLGTENLYFQSMTNTERPLAISAPEPRSLDLIFSDEARAALHSKYEIVEADPENIAG 68 >5CM6-A nrPDB Length = 358 Score = 30.5 bits (67), Expect = 1.7, Method: Composition-based stats. Identities = 7/19 (36%), Positives = 9/19 (47%) Query: 22 VDLQYEGAECGVNADVEKH 40 VDL E AD +K+ Sbjct: 11 VDLGTENLYFQSMADGKKY 29 >2RKQ-A nrPDB Length = 169 Score = 30.5 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 14/55 (25%), Positives = 28/55 (50%) Query: 367 QEHNENDQQIREGLEKAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQW 421 +E N + + E ++ +KQ+Q + YK+LG ++ + + +A L QW Sbjct: 107 EERAPNKEALDAAKELLEQAVKQAQLVEGYKLLGHRQVSATKSPGEALYALIQQW 161 >2OMK-A nrPDB Length = 231 Score = 30.1 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 14/32 (43%) Query: 22 VDLQYEGAECGVNADVEKHLELGKKLLAAGQL 53 VDL E NA + +H +LA G+ Sbjct: 11 VDLGTENLYFQSNAMINEHYIPQAIILANGEY 42 >4JB7-A nrPDB Length = 256 Score = 30.1 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 8/19 (42%), Positives = 9/19 (47%) Query: 22 VDLQYEGAECGVNADVEKH 40 VDL E NADV + Sbjct: 11 VDLGTENLYFQSNADVNLY 29 >2J90-A nrPDB Length = 304 Score = 30.1 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 13/42 (30%), Positives = 17/42 (40%), Gaps = 3/42 (7%) Query: 22 VDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAA 63 VDL E VE H E+G++ L +GQ A Sbjct: 11 VDLGTENLYFQSM--VEDHYEMGEE-LGSGQFAIVRKCRQKG 49 >5J0A-A nrPDB Length = 300 Score = 29.7 bits (65), Expect = 2.9, Method: Composition-based stats. Identities = 8/44 (18%), Positives = 21/44 (47%) Query: 392 KRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKA 435 YY LG + +E+ ++Y+K+ + ++ +++ A Sbjct: 247 DEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSA 290 >5LN3-Z nrPDB Length = 908 Score = 29.3 bits (64), Expect = 3.7, Method: Composition-based stats. Identities = 15/95 (15%), Positives = 33/95 (34%), Gaps = 12/95 (12%) Query: 362 DYETAQEHNENDQQIREGLEKAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQW 421 D + QE +E D+Q+++ LE LG K + + ++ R+ Sbjct: 38 DKDKEQELSEEDKQLQDELEMLVER------------LGEKDTSLYRPALEELRRQIRSS 85 Query: 422 HPDNFQNEEEKKKAEKKFIDIAAAKEVLSDPEMRK 456 + K + + E ++ E ++ Sbjct: 86 TTSMTSVPKPLKFLRPHYGKLKEIYENMAPGENKR 120 >3QOU-A nrPDB Length = 287 Score = 29.3 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 16/68 (23%), Positives = 25/68 (36%) Query: 153 EMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLK 212 E + QA+ +YT A+ L ++ + E+ L AE I A + LK Sbjct: 116 EEELKAQQAMQLMQESNYTDALPLLKDAWQLSNQNGEIGLLLAETLIALNRSEDAEAVLK 175 Query: 213 AASKLKND 220 D Sbjct: 176 TIPLQDQD 183 >3J3U-A nrPDB Length = 810 Score = 29.3 bits (64), Expect = 4.2, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 30/58 (51%) Query: 337 PDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLLKQSQKRD 394 P N+ L+ + + E+ Q++E A + +Q++RE +E ++ K+ Q ++ Sbjct: 410 PPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLREQVEDTKKSWKEKQGQE 467 >4G1T-A nrPDB Length = 472 Score = 29.3 bits (64), Expect = 4.4, Method: Composition-based stats. Identities = 12/43 (27%), Positives = 23/43 (53%) Query: 331 EVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNEND 373 E L+ P + L+ A+ Y ++ D+AI+ + A E+ N+ Sbjct: 238 EALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNN 280 >3PXI-A nrPDB Length = 758 Score = 29.0 bits (63), Expect = 4.7, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 30/58 (51%) Query: 337 PDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLLKQSQKRD 394 P N+ L+ + + E+ Q++E A + +Q++RE +E ++ K+ Q ++ Sbjct: 393 PPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLREQVEDTKKSWKEKQGQE 450 >5XJC-J nrPDB Length = 848 Score = 29.0 bits (63), Expect = 5.2, Method: Composition-based stats. Identities = 17/108 (15%), Positives = 40/108 (37%) Query: 52 QLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQR 111 ++ A S + A+D D N + + A + + + A + I + Sbjct: 257 EIQRARSIYERALDVDYRNITLWLKYAEMEMKNRQVNHARNIWDRAITTLPRVNQFWYKY 316 Query: 112 GHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRS 159 ++ G + A F++ ++ P E + ++ E+ R R+ Sbjct: 317 TYMEEMLGNVAGARQVFERWMEWQPEEQAWHSYINFELRYKEVDRART 364 >3PXG-A nrPDB Length = 468 Score = 29.0 bits (63), Expect = 5.3, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 30/58 (51%) Query: 337 PDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLLKQSQKRD 394 P N+ L+ + + E+ Q++E A + +Q++RE +E ++ K+ Q ++ Sbjct: 393 PPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLREQVEDTKKSWKEKQGQE 450 >5ZYP-A nrPDB Length = 390 Score = 28.2 bits (61), Expect = 8.9, Method: Composition-based stats. Identities = 56/257 (21%), Positives = 97/257 (37%), Gaps = 36/257 (14%) Query: 138 ENEEKEAQSQLI-------KSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAEL 190 EN EKE + K++E +L AL+ F + + + FL W A L Sbjct: 52 ENSEKEHWLTIALAYCNHGKTNEGIKLIEMALDVFQNSERASLHTFLT-------W-AHL 103 Query: 191 RELRAECF---IKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRE 247 + + KE E +A +LK A LYYQ G ++ +L Sbjct: 104 NLAKGQSLSVETKEHELTQAELNLKDAIGFDPTWIGNMLATVELYYQRGHYDKALETSD- 162 Query: 248 CLKLDQDHKRCFAHYKQVK-KLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTV 306 L + H +Q K L+ A+ L + Y + ++ ++ P + + Sbjct: 163 -LFVKSIHAEDHRSGRQSKPNCLFLLLRAKLLYQKKNYMASLKIFQELLVINP-VLQPDP 220 Query: 307 RSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETA 366 R +C KD K AI+ LQ+ P N +A + L+ + ++ + Sbjct: 221 RIGIGLCFWQLKDSK--MAIKSWQRALQLNPKNTSA------SILVL------LGEFRES 266 Query: 367 QEHNENDQQIREGLEKA 383 ++ ND+ +E KA Sbjct: 267 FTNSTNDKTFKEAFTKA 283 >3ZQ6-A nrPDB Length = 324 Score = 28.2 bits (61), Expect = 9.4, Method: Composition-based stats. Identities = 13/39 (33%), Positives = 19/39 (48%) Query: 416 KLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDPEM 454 K L + D + + + E I AA+EV+SDPE Sbjct: 184 KNILPFMGDEEEEDRALQDMEATKKQINAAREVMSDPER 222 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.127 0.325 Lambda K H 0.267 0.0384 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,428,037 Number of Sequences: 36641 Number of extensions: 655321 Number of successful extensions: 3497 Number of sequences better than 10.0: 112 Number of HSP's better than 10.0 without gapping: 108 Number of HSP's successfully gapped in prelim test: 78 Number of HSP's that attempted gapping in prelim test: 3050 Number of HSP's gapped (non-prelim): 396 length of query: 504 length of database: 10,336,785 effective HSP length: 101 effective length of query: 403 effective length of database: 6,636,044 effective search space: 2674325732 effective search space used: 2674325732 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (28.2 bits)