BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q13216 (396 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4A11-B nrPDB 826 0.0 5MZH-A nrPDB 73 2e-13 3C9C-A nrPDB 72 5e-13 6F3T-A nrPDB 70 1e-12 6MZM-G nrPDB 70 2e-12 5WJC-A nrPDB 69 3e-12 5G04-R nrPDB 69 5e-12 3CFV-B nrPDB 68 7e-12 5Y1U-A nrPDB 68 7e-12 5XYI-g nrPDB 68 8e-12 4GGA-A nrPDB 68 8e-12 5LCW-Q nrPDB 68 9e-12 5M25-A nrPDB 67 1e-11 2H9P-A nrPDB 66 3e-11 6QX9-4B nrPDB 64 9e-11 6HQA-B nrPDB 64 1e-10 5NNZ-B nrPDB 64 2e-10 4N14-A nrPDB 62 4e-10 6QX9-5O nrPDB 62 4e-10 5GAN-H nrPDB 61 8e-10 1NR0-A nrPDB 60 1e-09 4E5Z-B nrPDB 59 4e-09 5YZG-W nrPDB 58 6e-09 6QDV-o nrPDB 58 6e-09 5Z56-q nrPDB 56 2e-08 4LG8-A nrPDB 56 2e-08 5Y88-O nrPDB 56 3e-08 1VYH-C nrPDB 55 5e-08 5OQL-J nrPDB 55 8e-08 6ID0-T nrPDB 54 1e-07 4XYI-A nrPDB 54 1e-07 5FL8-q nrPDB 54 2e-07 6ELZ-p nrPDB 53 2e-07 4V6W-Ag nrPDB 52 3e-07 3FM0-A nrPDB 52 4e-07 2HES-X nrPDB 50 1e-06 5FVM-C nrPDB 50 1e-06 5CXC-A nrPDB 50 2e-06 6HHQ-h nrPDB 50 2e-06 3JB9-L nrPDB 49 4e-06 2PM9-A nrPDB 49 4e-06 4BTS-AR nrPDB 49 4e-06 3JB9-g nrPDB 49 4e-06 4AEZ-A nrPDB 48 8e-06 6J6H-n nrPDB 48 8e-06 5WYJ-BC nrPDB 47 1e-05 6G51-g nrPDB 47 2e-05 5WBU-D nrPDB 46 2e-05 5M89-A nrPDB 46 2e-05 5WYK-BB nrPDB 46 3e-05 6EMK-B nrPDB 46 3e-05 6Q8F-A nrPDB 46 3e-05 4V7E-Bg nrPDB 45 4e-05 3JAP-g nrPDB 45 6e-05 5NZU-C nrPDB 45 6e-05 3MKQ-A nrPDB 45 6e-05 2YNP-A nrPDB 45 7e-05 3EI3-B nrPDB 45 7e-05 5WLC-LO nrPDB 45 8e-05 4PSX-B nrPDB 45 8e-05 5I2T-A nrPDB 44 9e-05 5A31-R nrPDB 44 2e-04 4BH6-A nrPDB 44 2e-04 5L9T-R nrPDB 43 2e-04 5OPT-p nrPDB 43 3e-04 5BJS-A nrPDB 43 3e-04 3DM0-A nrPDB 42 3e-04 6EOJ-D nrPDB 42 4e-04 2AQ5-A nrPDB 41 7e-04 5OQL-L nrPDB 41 0.001 5K1B-B nrPDB 41 0.001 4V8M-A7 nrPDB 40 0.001 3W15-A nrPDB 40 0.002 5WLC-LJ nrPDB 40 0.002 6GMH-W nrPDB 40 0.002 6N9G-C nrPDB 39 0.003 5UZ7-B nrPDB 39 0.006 5FA5-B nrPDB 38 0.010 3F3P-A nrPDB 37 0.014 6CHG-D nrPDB 37 0.014 4YCZ-A nrPDB 36 0.027 3JRO-A nrPDB 36 0.027 3JRP-A nrPDB 36 0.028 5WLC-LU nrPDB 36 0.029 4BZK-B nrPDB 35 0.041 6BX3-B nrPDB 35 0.046 4U1E-I nrPDB 35 0.058 4OWR-A nrPDB 35 0.073 4L9O-A nrPDB 35 0.080 5OV3-A nrPDB 34 0.10 5N4A-A nrPDB 34 0.12 3JZG-A nrPDB 34 0.13 4J0W-A nrPDB 34 0.14 5OQL-d nrPDB 33 0.21 3ODT-A nrPDB 33 0.27 4XFV-A nrPDB 32 0.45 5OQL-X nrPDB 32 0.50 6E29-D nrPDB 32 0.56 5WLC-SG nrPDB 32 0.59 4J0X-A nrPDB 32 0.64 4G56-B nrPDB 32 0.65 4HR3-A nrPDB 31 1.1 5YZG-2 nrPDB 31 1.2 5V7Q-R nrPDB 30 1.2 5O60-S nrPDB 30 1.2 6BX3-A nrPDB 30 1.3 5A9Q-0 nrPDB 30 1.3 4IP7-A nrPDB 30 1.4 5WLC-LW nrPDB 30 2.0 5K0Y-T nrPDB 30 2.1 2P9P-C nrPDB 30 2.1 6CHG-A nrPDB 30 2.3 1PI6-A nrPDB 30 2.3 3ACP-A nrPDB 30 2.5 6GC1-A nrPDB 29 3.0 5MWJ-A nrPDB 29 4.5 3BG0-A nrPDB 28 4.9 5K19-A nrPDB 28 4.9 5WLC-LH nrPDB 28 5.5 5MC6-j nrPDB 28 6.0 6F1U-h nrPDB 28 7.0 4GKL-A nrPDB 28 7.4 6C0F-s nrPDB 28 7.6 6EM1-m nrPDB 28 8.5 6CB1-s nrPDB 28 9.4 >4A11-B nrPDB Length = 408 Score = 826 bits (2133), Expect = 0.0, Method: Compositional matrix adjust. Identities = 396/396 (100%), Positives = 396/396 (100%) Query: 1 MLGFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYML 60 MLGFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYML Sbjct: 1 MLGFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYML 60 Query: 61 SGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSF 120 SGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSF Sbjct: 61 SGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSF 120 Query: 121 DKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSH 180 DKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSH Sbjct: 121 DKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSH 180 Query: 181 ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA 240 ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA Sbjct: 181 ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA 240 Query: 241 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS 300 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS Sbjct: 241 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS 300 Query: 301 CGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA 360 CGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA Sbjct: 301 CGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA 360 Query: 361 WVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDEEG 396 WVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDEEG Sbjct: 361 WVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDEEG 396 >5MZH-A nrPDB Length = 452 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 78/322 (24%), Positives = 129/322 (40%), Gaps = 70/322 (21%) Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMF 115 G +++G D L+D Q YYT K H+ + + + P T + Sbjct: 149 GDKIVTGSFDKTCKLWDAYTG--QLYYTLKG-----------HQTEIVCLSFNPQST-II 194 Query: 116 TSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVS----TKHCLVAVGTRGPKVQLC 171 + S D T K+WD T Q T+ H VS T L+ G+ +L Sbjct: 195 ATGSMDNTAKLWDVETGQE------RATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLW 248 Query: 172 DLKSGSCSHILQGHRQEILAVSWSPRYDY---ILATASADSRVKLWDVRRASGCLITLDQ 228 D+++G C H+L GHR E+ S +++Y ++ + S D +LWDVR CL Sbjct: 249 DVRTGQCVHVLSGHRGEVS----STQFNYAGTLVVSGSIDCTSRLWDVRSGR-CL----- 298 Query: 229 HNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVC 288 S H +V + F + G +++ D RL+++ G VC Sbjct: 299 ----------SVKQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTG---------VC 339 Query: 289 NNSKKGLKFTVSCGCSSEFVFVPYGS---------TIAVYTVYSGEQITMLKGHYKTVDC 339 ++ G + G S+ F P G+ T ++ +GE + +L+GH + Sbjct: 340 QHTLVGHE-----GEISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQVLEGHTDEIFS 394 Query: 340 CVFQSNFQELYSGSRDCNILAW 361 C F + +GS+D W Sbjct: 395 CAFNYEGDFIITGSKDNTCRIW 416 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 70/253 (27%), Positives = 111/253 (43%), Gaps = 47/253 (18%) Query: 115 FTSSSFDKTLKVWDTNTLQTADVFNFE---ETVYSHHM-SPVSTKHCLVAVGTRGPKVQL 170 F + S+D+T KVW NT +VF E VY+ +P K + G+ +L Sbjct: 109 FITGSYDRTCKVW--NTFTGEEVFTLEGHKNVVYAIAFNNPYGDK---IVTGSFDKTCKL 163 Query: 171 CDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHN 230 D +G + L+GH+ EI+ +S++P+ I+AT S D+ KLWDV Sbjct: 164 WDAYTGQLYYTLKGHQTEIVCLSFNPQ-STIIATGSMDNTAKLWDVETGQ---------- 212 Query: 231 GKKSQAVESANTA-HNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCN 289 E A A H ++ L F + G ++T D+ RLW+ G+ C Sbjct: 213 -------ERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQ---------CV 256 Query: 290 NSKKGLKFTVSCGCSSEF----VFVPYGS---TIAVYTVYSGEQITMLKGHYKTVDCCVF 342 + G + VS S++F V GS T ++ V SG +++ +GH V F Sbjct: 257 HVLSGHRGEVS---STQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAF 313 Query: 343 QSNFQELYSGSRD 355 + ++ S S D Sbjct: 314 DAAGTKMVSASAD 326 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 45/178 (25%), Positives = 74/178 (41%), Gaps = 22/178 (12%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTKH 156 HR V + Q + + + S S D T ++WD + + V + V TK Sbjct: 262 HRGEVSSTQ-FNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTK- 319 Query: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 +V+ G +L +G C H L GH EI V+++P+ ++ TAS+D +LWD Sbjct: 320 -MVSASADG-SARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLI-TASSDKTCRLWDC 376 Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 CL L+ H ++ F +G ++T DN R+W + Sbjct: 377 DTGE-CLQVLE---------------GHTDEIFSCAFNYEGDFIITGSKDNTCRIWKA 418 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 41/183 (22%), Positives = 69/183 (37%), Gaps = 27/183 (14%) Query: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESAN 241 L+GH+ + A++++ Y + T S D KLWD + G+ ++ Sbjct: 132 LEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDA------------YTGQLYYTLK--- 176 Query: 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSC 301 H ++ L F + T DN +LW+ G+ G VS Sbjct: 177 -GHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAE--------IVSL 227 Query: 302 GCSSEFVFVPYGS---TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNI 358 G ++ + GS ++ V +G+ + +L GH V F + SGS DC Sbjct: 228 GFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTS 287 Query: 359 LAW 361 W Sbjct: 288 RLW 290 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 41/166 (24%), Positives = 63/166 (37%), Gaps = 61/166 (36%) Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDV-HRYSVETVQWYPHDTGM 114 G M+S +DG S + Y+T VC H V H + V + P T + Sbjct: 317 GTKMVSASADG----------SARLYHTLTGVCQ----HTLVGHEGEISKVAFNPQGTRL 362 Query: 115 FTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLK 174 T+SS DKT ++WD CD Sbjct: 363 ITASS-DKTCRLWD------------------------------------------CD-- 377 Query: 175 SGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRAS 220 +G C +L+GH EI + +++ D+I+ T S D+ ++W AS Sbjct: 378 TGECLQVLEGHTDEIFSCAFNYEGDFII-TGSKDNTCRIWKALTAS 422 Score = 36.2 bits (82), Expect = 0.024, Method: Compositional matrix adjust. Identities = 28/119 (23%), Positives = 43/119 (36%), Gaps = 4/119 (3%) Query: 243 AHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCG 302 AH + F G +T D ++WN+ GE G N + F G Sbjct: 92 AHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGH--KNVVYAIAFNNPYG 149 Query: 303 CSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 + V + T ++ Y+G+ LKGH + C F + +GS D W Sbjct: 150 --DKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLW 206 >3C9C-A nrPDB Length = 432 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 59/223 (26%), Positives = 97/223 (43%), Gaps = 20/223 (8%) Query: 58 YMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTS 117 Y+LS D I L+D+ + ++ G H VE V W+ +F S Sbjct: 198 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTG------HTAVVEDVAWHLLHESLFGS 251 Query: 118 SSFDKTLKVWDT---NTLQ---TADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLC 171 + D+ L +WDT NT + T D E S +P S ++A G+ V L Sbjct: 252 VADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLS--FNPYS--EFILATGSADKTVALW 307 Query: 172 DLKSGSCS-HILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHN 230 DL++ H + H+ EI V WSP + ILA++ D R+ +WD+ + T D + Sbjct: 308 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED 367 Query: 231 GKKSQAVESANTAHNGKVNGLCFTSDGLHLL-TVGTDNRMRLW 272 G + H K++ + + ++ +V DN M++W Sbjct: 368 GPPELLF--IHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 408 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 23/180 (12%) Query: 105 VQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVST------KHCL 158 + W P+ G S+S D T+ +WD N + +++ H + V L Sbjct: 189 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 248 Query: 159 VAVGTRGPKVQLCDLKSGSCS---HILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 K+ + D ++ + S H + H E+ +S++P ++ILAT SAD V LWD Sbjct: 249 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 308 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 +R L + + H K + + + HN + L + GTD R+ +W+ S Sbjct: 309 LRNLKLKLHSFESH---KDEIFQVQWSPHNETI-----------LASSGTDRRLHVWDLS 354 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 36/175 (20%), Positives = 65/175 (37%), Gaps = 42/175 (24%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H +N L P + +G +D + L+DL N + + + H+ Sbjct: 278 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF------------ESHKDE 325 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 + VQW PH+ + SS D+ L VWD +S + + Sbjct: 326 IFQVQWSPHNETILASSGTDRRLHVWD--------------------LSKIGEEQSTEDA 365 Query: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 P++ I GH +I SW+P +I+ + S D+ +++W + Sbjct: 366 EDGPPELLF----------IHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 410 >6F3T-A nrPDB Length = 608 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 69/279 (24%), Positives = 114/279 (40%), Gaps = 58/279 (20%) Query: 15 PLRLRRAESTRRVLGLELNKDRDVERI--------------HGGGINTLDIEPVEGRYML 60 P +LR + + ++ D +ERI H G + P + Y+L Sbjct: 309 PKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSP-DRNYLL 367 Query: 61 SGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSF 120 S DG + L+ L+ + C +G H Y V Q+ P+ F S Sbjct: 368 SSSEDGTVRLWSLQTFT----------CLVGYKG---HNYPVWDTQFSPYGY-YFVSGGH 413 Query: 121 DKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHC-----LVAVGTRGPKVQLCDLKS 175 D+ ++W T+ Q +F + H++ V+ VA G+ V+L D+ + Sbjct: 414 DRVARLWATDHYQPLRIF-------AGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 466 Query: 176 GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQ 235 G+C I GH+ I ++++SP + LAT + D RV LWD+ G ++ Sbjct: 467 GNCVRIFTGHKGPIHSLTFSPNGRF-LATGATDGRVLLWDI--GHGLMV----------- 512 Query: 236 AVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 H V L F+ DG L + DN +RLW++ Sbjct: 513 ---GELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA 548 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 49/197 (24%), Positives = 86/197 (43%), Gaps = 30/197 (15%) Query: 169 QLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQ 228 ++ D K+ S IL GH + S+SP +Y+L++ S D V+LW ++ + CL+ Sbjct: 334 RIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSS-SEDGTVRLWSLQTFT-CLV---- 387 Query: 229 HNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVC 288 G K HN V F+ G + ++ G D RLW + + + + G + Sbjct: 388 --GYK---------GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLA 436 Query: 289 NNSKKGLKFTVSCG-CSSEFVFVPYGS---TIAVYTVYSGEQITMLKGHYKTVDCCVFQS 344 + V+C +V GS T+ ++ V +G + + GH + F Sbjct: 437 D---------VNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSP 487 Query: 345 NFQELYSGSRDCNILAW 361 N + L +G+ D +L W Sbjct: 488 NGRFLATGATDGRVLLW 504 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 44/185 (23%), Positives = 71/185 (38%), Gaps = 38/185 (20%) Query: 201 ILATASADSRVKLWDVR-------RASGCLITLDQHNGKKSQAVESANTA--------HN 245 ++A ADS V++W V + + L +D+ + + + TA H+ Sbjct: 292 LIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHS 351 Query: 246 GKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSS 305 G V G F+ D +LL+ D +RLW S LV Y KG + V Sbjct: 352 GPVYGASFSPDRNYLLSSSEDGTVRLW-SLQTFTCLVGY--------KGHNYPV-----W 397 Query: 306 EFVFVPYGSTIA---------VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDC 356 + F PYG ++ + + + GH V+C F N + +GS D Sbjct: 398 DTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADR 457 Query: 357 NILAW 361 + W Sbjct: 458 TVRLW 462 >6MZM-G nrPDB Length = 800 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 63/238 (26%), Positives = 103/238 (43%), Gaps = 44/238 (18%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H G + P + Y+LS DG + L+ L+ + C +G H Y Sbjct: 542 HSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFT----------CLVGYKG---HNYP 587 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHC---- 157 V Q+ P+ F S D+ ++W T+ Q +F + H++ V+ Sbjct: 588 VWDTQFSPYGY-YFVSGGHDRVARLWATDHYQPLRIF-------AGHLADVNCTRFHPNS 639 Query: 158 -LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 VA G+ V+L D+ +G+C I GH+ I ++++SP + LAT + D RV LWD+ Sbjct: 640 NYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRF-LATGATDGRVLLWDI 698 Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 G + + + G H V L F+ DG L + DN +RLW++ Sbjct: 699 ----GHGLMVGELKG------------HTDTVCSLRFSRDGEILASGSMDNTVRLWDA 740 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 46/185 (24%), Positives = 80/185 (43%), Gaps = 30/185 (16%) Query: 181 ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA 240 IL GH + S+SP +Y+L++ S D V+LW ++ + CL+ G K Sbjct: 538 ILYGHSGPVYGASFSPDRNYLLSS-SEDGTVRLWSLQTFT-CLV------GYK------- 582 Query: 241 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS 300 HN V F+ G + ++ G D RLW + + + + G + + V+ Sbjct: 583 --GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLAD---------VN 631 Query: 301 CG-CSSEFVFVPYGS---TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDC 356 C +V GS T+ ++ V +G + + GH + F N + L +G+ D Sbjct: 632 CTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDG 691 Query: 357 NILAW 361 +L W Sbjct: 692 RVLLW 696 >5WJC-A nrPDB Length = 430 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 60/228 (26%), Positives = 103/228 (45%), Gaps = 23/228 (10%) Query: 59 MLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSS 118 + +G D VI L+D++ S S T K + I + H H V VQ++P + S Sbjct: 198 LATGAEDQVICLWDVQTQSFTSSET-KVISPIAKYH--RHTDIVNDVQFHPQHEALLASV 254 Query: 119 SFDKTLKVWDTNTLQTADVFNFEE---TVYSHHMSPVST------KHCLVAVGTRGPKVQ 169 S D TL++ DT N EE V H ++ L+A + V Sbjct: 255 SDDCTLQIHDTR-------LNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVA 307 Query: 170 LCDLKSGSCS-HILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQ 228 L DL++ H L+GH E+ + WSP + ILA++S D RV +WD+ + D Sbjct: 308 LWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDA 367 Query: 229 HNGKKSQAVESANTAHNGKVNGLCFTSDGLHLL-TVGTDNRMRLWNSS 275 +G S + + H +++ + + ++ ++ DN +++W+ S Sbjct: 368 EDG--SPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIWSPS 413 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 40/200 (20%), Positives = 73/200 (36%), Gaps = 49/200 (24%) Query: 24 TRRVLGLELNKDRDVERI---HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQS 80 T ++ LN + + ++ H IN + I P + + +D + L+DL N Q Sbjct: 259 TLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDLRNP-YQR 317 Query: 81 YYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNF 140 +T + H V ++W PHD + SSS D+ + +WD + Sbjct: 318 LHTLEG-----------HEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKI-------- 358 Query: 141 EETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQ--GHRQEILAVSWSPRY 198 G + D + GS + GH I SW P Sbjct: 359 ------------------------GEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNE 394 Query: 199 DYILATASADSRVKLWDVRR 218 +++ + + D+ +++W R Sbjct: 395 RWVVGSLADDNILQIWSPSR 414 >5G04-R nrPDB Length = 499 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 70/294 (23%), Positives = 129/294 (43%), Gaps = 36/294 (12%) Query: 69 VLYDLENSSRQSYYTCKAVCSIGR---DHPDVHR-YSVETVQWYPHDTGMFTSSSFDKTL 124 VLY + + S TC+ + S+ D P++ Y + V W +G + + D ++ Sbjct: 150 VLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDW---SSGNVLAVALDNSV 206 Query: 125 KVWDTNTLQTADVFNFEETVYSHHMSPVS--TKHCLVAVGTRGPKVQLCDLKSGSCSHIL 182 +W ++ + E+ ++S V+ + +AVGT +VQL D++ + Sbjct: 207 YLWSASSGDILQLLQMEQP--GEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNM 264 Query: 183 QGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANT 242 H + ++SW+ YIL++ S + DVR A + TL + Sbjct: 265 TSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATL---------------S 306 Query: 243 AHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCG 302 H+ +V GL + DG HL + G DN + +W S+ GE V + + +K C Sbjct: 307 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPL-QTFTQHQGAVKAVAWCP 365 Query: 303 CSSEFVFVPYGST---IAVYTVYSGEQITMLKGHYKTVDCCVFQS-NFQELYSG 352 S + G++ I ++ V SG ++ + H + C + S +++EL SG Sbjct: 366 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV--CSILWSPHYKELISG 417 Score = 35.0 bits (79), Expect = 0.057, Method: Compositional matrix adjust. Identities = 49/254 (19%), Positives = 87/254 (34%), Gaps = 56/254 (22%) Query: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKA-----------VCSIGRDHPDVHRYSVE 103 EG Y+ G S + L+D++ R T + + S G +H + V Sbjct: 237 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVR 296 Query: 104 T-----------------VQWYPHDTGMFTSSSFDKTLKVWDTNT-------LQTADVFN 139 ++W P D S D + VW + LQT Sbjct: 297 VAEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQT--FTQ 353 Query: 140 FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRY- 198 + V + P + GT +++ ++ SG+C + H Q + ++ WSP Y Sbjct: 354 HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYK 412 Query: 199 DYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGL 258 + I A +++ +W + A + H +V L + DG Sbjct: 413 ELISGHGFAQNQLVIWKY----------------PTMAKVAELKGHTSRVLSLTMSPDGA 456 Query: 259 HLLTVGTDNRMRLW 272 + + D +RLW Sbjct: 457 TVASAAADETLRLW 470 >3CFV-B nrPDB Length = 414 Score = 68.2 bits (165), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 54/223 (24%), Positives = 94/223 (42%), Gaps = 20/223 (8%) Query: 58 YMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTS 117 ++LS D + L+D+ ++ G H VE V W+ +F S Sbjct: 194 HLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTG------HSAVVEDVAWHLLHESLFGS 247 Query: 118 SSFDKTLKVWDTNTLQTA------DVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLC 171 + D+ L +WDT + T+ D E S +P S ++A G+ V L Sbjct: 248 VADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLS--FNPYSE--FILATGSADKTVALW 303 Query: 172 DLKSGSCS-HILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHN 230 DL++ H + H+ EI V WSP + ILA++ D R+ +WD+ + D + Sbjct: 304 DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAED 363 Query: 231 GKKSQAVESANTAHNGKVNGLCFTSDGLHLL-TVGTDNRMRLW 272 G + H K++ + + ++ +V DN M++W Sbjct: 364 GPPELLF--IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 404 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 35/175 (20%), Positives = 66/175 (37%), Gaps = 42/175 (24%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H +N L P + +G +D + L+DL N + +T ++ H+ Sbjct: 274 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL-KLKLHTFES-----------HKDE 321 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 + V W PH+ + SS D+ L VWD +S + + Sbjct: 322 IFQVHWSPHNETILASSGTDRRLNVWD--------------------LSKIGEEQSAEDA 361 Query: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 P++ I GH +I SW+P +++ + S D+ +++W + Sbjct: 362 EDGPPELLF----------IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 406 >5Y1U-A nrPDB Length = 456 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 55/223 (24%), Positives = 94/223 (42%), Gaps = 20/223 (8%) Query: 58 YMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTS 117 ++LS D I L+D+ ++ G H VE V W+ +F S Sbjct: 223 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTG------HTAVVEDVSWHLLHESLFGS 276 Query: 118 SSFDKTLKVWDTNTLQTA------DVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLC 171 + D+ L +WDT + T+ D E S +P S ++A G+ V L Sbjct: 277 VADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLS--FNPYS--EFILATGSADKTVALW 332 Query: 172 DLKSGSCS-HILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHN 230 DL++ H + H+ EI V WSP + ILA++ D R+ +WD+ + D + Sbjct: 333 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 392 Query: 231 GKKSQAVESANTAHNGKVNGLCFTSDGLHLL-TVGTDNRMRLW 272 G + H K++ + + ++ +V DN M++W Sbjct: 393 GPPELLF--IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 433 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 46/180 (25%), Positives = 81/180 (45%), Gaps = 23/180 (12%) Query: 105 VQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVST------KHCL 158 + W P+ +G S+S D T+ +WD + + +T+++ H + V L Sbjct: 214 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 273 Query: 159 VAVGTRGPKVQLCDLKSGSCS---HILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 K+ + D +S + S H + H E+ +S++P ++ILAT SAD V LWD Sbjct: 274 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 333 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 +R L + + H K + + + HN + L + GTD R+ +W+ S Sbjct: 334 LRNLKLKLHSFESH---KDEIFQVQWSPHNETI-----------LASSGTDRRLNVWDLS 379 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 38/175 (21%), Positives = 66/175 (37%), Gaps = 42/175 (24%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H +N L P + +G +D + L+DL N + + + H+ Sbjct: 303 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF------------ESHKDE 350 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 + VQW PH+ + SS D+ L VWD + + SP + Sbjct: 351 IFQVQWSPHNETILASSGTDRRLNVWDLSKI-------------GEEQSPEDAE------ 391 Query: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 GP L I GH +I SW+P +++ + S D+ +++W + Sbjct: 392 --DGPPELLF---------IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 435 >5XYI-g nrPDB Length = 335 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 76/342 (22%), Positives = 145/342 (42%), Gaps = 65/342 (19%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H I +++I+ E Y++S D +++ L + Q + IG H + Sbjct: 32 HNAAIESIEIDN-EHNYLVSASRDKSALVWKLNRTQEQ--WATPFTRLIG------HNHF 82 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF-NFEETVYSHHMSPVSTKHCLVA 160 V V D +SS+D TL++WD +T T +F ++ V SP + + +++ Sbjct: 83 VSDVS-LSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRR--IIS 139 Query: 161 VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSW------SPRYD----YILATASADSR 210 VG R +V++ + IL ++ E+ SW +P D ++A D + Sbjct: 140 VG-RDNQVKIWN--------ILGENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDGK 190 Query: 211 VKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMR 270 V +W + + + + AH+G+ + FT DG ++T G+D ++ Sbjct: 191 VYIWSIEKEAKLIKEFK---------------AHDGRCTSVDFTPDGKWVITGGSDRKVV 235 Query: 271 LWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITML 330 +W + NG T + + + +C + Y IAV+ + + +QI ++ Sbjct: 236 MWLTENGAKT------ISFTAPSPVHAVAACPTQAWICAATY-EGIAVWDIGAKQQIDLV 288 Query: 331 KGHYK---------TVD--CCVFQSNFQELYSGSRDCNILAW 361 + ++K T D C + ++ LYSG D +I AW Sbjct: 289 QPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIRAW 330 >4GGA-A nrPDB Length = 420 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 70/294 (23%), Positives = 129/294 (43%), Gaps = 36/294 (12%) Query: 69 VLYDLENSSRQSYYTCKAVCSIGR---DHPDVHR-YSVETVQWYPHDTGMFTSSSFDKTL 124 VLY + + S TC+ + S+ D P++ Y + V W +G + + D ++ Sbjct: 71 VLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDW---SSGNVLAVALDNSV 127 Query: 125 KVWDTNTLQTADVFNFEETVYSHHMSPVS--TKHCLVAVGTRGPKVQLCDLKSGSCSHIL 182 +W ++ + E+ ++S V+ + +AVGT +VQL D++ + Sbjct: 128 YLWSASSGDILQLLQMEQP--GEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNM 185 Query: 183 QGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANT 242 H + ++SW+ YIL++ S + DVR A + TL + Sbjct: 186 TSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATL---------------S 227 Query: 243 AHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCG 302 H+ +V GL + DG HL + G DN + +W S+ GE V + + +K C Sbjct: 228 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPL-QTFTQHQGAVKAVAWCP 286 Query: 303 CSSEFVFVPYGST---IAVYTVYSGEQITMLKGHYKTVDCCVFQS-NFQELYSG 352 S + G++ I ++ V SG ++ + H + C + S +++EL SG Sbjct: 287 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV--CSILWSPHYKELISG 338 Score = 35.0 bits (79), Expect = 0.051, Method: Compositional matrix adjust. Identities = 49/254 (19%), Positives = 87/254 (34%), Gaps = 56/254 (22%) Query: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKA-----------VCSIGRDHPDVHRYSVE 103 EG Y+ G S + L+D++ R T + + S G +H + V Sbjct: 158 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVR 217 Query: 104 T-----------------VQWYPHDTGMFTSSSFDKTLKVWDTNT-------LQTADVFN 139 ++W P D S D + VW + LQT Sbjct: 218 VAEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQT--FTQ 274 Query: 140 FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRY- 198 + V + P + GT +++ ++ SG+C + H Q + ++ WSP Y Sbjct: 275 HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYK 333 Query: 199 DYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGL 258 + I A +++ +W + A + H +V L + DG Sbjct: 334 ELISGHGFAQNQLVIWKY----------------PTMAKVAELKGHTSRVLSLTMSPDGA 377 Query: 259 HLLTVGTDNRMRLW 272 + + D +RLW Sbjct: 378 TVASAAADETLRLW 391 >5LCW-Q nrPDB Length = 374 Score = 67.8 bits (164), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 70/294 (23%), Positives = 129/294 (43%), Gaps = 36/294 (12%) Query: 69 VLYDLENSSRQSYYTCKAVCSIG---RDHPDVHR-YSVETVQWYPHDTGMFTSSSFDKTL 124 VLY + + S TC+ + S+ D P++ Y + V W +G + + D ++ Sbjct: 25 VLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDW---SSGNVLAVALDNSV 81 Query: 125 KVWDTNTLQTADVFNFEETVYSHHMSPVS--TKHCLVAVGTRGPKVQLCDLKSGSCSHIL 182 +W ++ + E+ ++S V+ + +AVGT +VQL D++ + Sbjct: 82 YLWSASSGDILQLLQMEQP--GEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNM 139 Query: 183 QGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANT 242 H + ++SW+ YIL++ S + DVR A + TL + Sbjct: 140 TSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATL---------------S 181 Query: 243 AHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCG 302 H+ +V GL + DG HL + G DN + +W S+ GE V + + +K C Sbjct: 182 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPL-QTFTQHQGAVKAVAWCP 240 Query: 303 CSSEFVFVPYGST---IAVYTVYSGEQITMLKGHYKTVDCCVFQS-NFQELYSG 352 S + G++ I ++ V SG ++ + H + C + S +++EL SG Sbjct: 241 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV--CSILWSPHYKELISG 292 Score = 35.0 bits (79), Expect = 0.053, Method: Compositional matrix adjust. Identities = 49/254 (19%), Positives = 87/254 (34%), Gaps = 56/254 (22%) Query: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKA-----------VCSIGRDHPDVHRYSVE 103 EG Y+ G S + L+D++ R T + + S G +H + V Sbjct: 112 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVR 171 Query: 104 T-----------------VQWYPHDTGMFTSSSFDKTLKVWDTNT-------LQTADVFN 139 ++W P D S D + VW + LQT Sbjct: 172 VAEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQT--FTQ 228 Query: 140 FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRY- 198 + V + P + GT +++ ++ SG+C + H Q + ++ WSP Y Sbjct: 229 HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYK 287 Query: 199 DYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGL 258 + I A +++ +W + A + H +V L + DG Sbjct: 288 ELISGHGFAQNQLVIWKY----------------PTMAKVAELKGHTSRVLSLTMSPDGA 331 Query: 259 HLLTVGTDNRMRLW 272 + + D +RLW Sbjct: 332 TVASAAADETLRLW 345 >5M25-A nrPDB Length = 434 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 66/249 (26%), Positives = 112/249 (44%), Gaps = 39/249 (15%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTKH 156 H+ + V W D+ + S+S DKTLK+WD ++ + V+ + +P S Sbjct: 186 HKLGISDVAW-SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-- 242 Query: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 L+ G+ V++ D+K+G C L H + AV ++ R ++ ++S D ++WD Sbjct: 243 -LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDT 300 Query: 217 RRASG-CLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 ASG CL TL + N V+ + F+ +G ++L DN ++LW+ S Sbjct: 301 --ASGQCLKTLIDDD--------------NPPVSFVKFSPNGKYILAATLDNTLKLWDYS 344 Query: 276 NGENTLVNYG----KVC---NNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQIT 328 G+ G K C N S G K+ VS G V+ ++ + + E + Sbjct: 345 KGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS-GSEDNLVY--------IWNLQTKEIVQ 395 Query: 329 MLKGHYKTV 337 L+GH V Sbjct: 396 KLQGHTDVV 404 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 68/282 (24%), Positives = 124/282 (43%), Gaps = 57/282 (20%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMS----PVS 153 H +V +V++ P+ + SSS DK +K+W A FE+T+ H + S Sbjct: 144 HTKAVSSVKFSPNGEWL-ASSSADKLIKIWG------AYDGKFEKTISGHKLGISDVAWS 196 Query: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKL 213 + L+ + +++ D+ SG C L+GH + +++P+ + I+ + S D V++ Sbjct: 197 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV-SGSFDESVRI 255 Query: 214 WDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 WDV+ CL TL AH+ V+ + F DG +++ D R+W+ Sbjct: 256 WDVKTGK-CLKTL---------------PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 299 Query: 274 SSNGE---------NTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSG 324 +++G+ N V++ K N K L T+ +T+ ++ G Sbjct: 300 TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLD-------------NTLKLWDYSKG 346 Query: 325 EQITMLKGHYKTVDCCVFQSNF-----QELYSGSRDCNILAW 361 + + GH K C+F +NF + + SGS D + W Sbjct: 347 KCLKTYTGH-KNEKYCIF-ANFSVTGGKWIVSGSEDNLVYIW 386 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 32/130 (24%), Positives = 58/130 (44%), Gaps = 5/130 (3%) Query: 232 KKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNS 291 K + A++ H V+ + F+ +G L + D +++W + +G+ + K + Sbjct: 132 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK-----FEKTISGH 186 Query: 292 KKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYS 351 K G+ S+ V T+ ++ V SG+ + LKGH V CC F + S Sbjct: 187 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 246 Query: 352 GSRDCNILAW 361 GS D ++ W Sbjct: 247 GSFDESVRIW 256 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 41/183 (22%), Positives = 81/183 (44%), Gaps = 32/183 (17%) Query: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESAN 241 L GH + + +V +SP ++ LA++SAD +K+W ++GK E Sbjct: 141 LAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGA------------YDGK----FEKTI 183 Query: 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKG-LKFTVS 300 + H ++ + ++SD L++ D +++W+ S+G+ C + KG + Sbjct: 184 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK---------CLKTLKGHSNYVFC 234 Query: 301 CGCSSEFVFVPYGS---TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRD-- 355 C + + + GS ++ ++ V +G+ + L H V F + + S S D Sbjct: 235 CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 294 Query: 356 CNI 358 C I Sbjct: 295 CRI 297 >2H9P-A nrPDB Length = 329 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 66/249 (26%), Positives = 112/249 (44%), Gaps = 39/249 (15%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTKH 156 H+ + V W D+ + S+S DKTLK+WD ++ + V+ + +P S Sbjct: 81 HKLGISDVAW-SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-- 137 Query: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 L+ G+ V++ D+K+G C L H + AV ++ R ++ ++S D ++WD Sbjct: 138 -LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDT 195 Query: 217 RRASG-CLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 ASG CL TL + N V+ + F+ +G ++L DN ++LW+ S Sbjct: 196 --ASGQCLKTLIDDD--------------NPPVSFVKFSPNGKYILAATLDNTLKLWDYS 239 Query: 276 NGENTLVNYG----KVC---NNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQIT 328 G+ G K C N S G K+ VS G V+ ++ + + E + Sbjct: 240 KGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS-GSEDNLVY--------IWNLQTKEIVQ 290 Query: 329 MLKGHYKTV 337 L+GH V Sbjct: 291 KLQGHTDVV 299 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 68/282 (24%), Positives = 124/282 (43%), Gaps = 57/282 (20%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMS----PVS 153 H +V +V++ P+ + SSS DK +K+W A FE+T+ H + S Sbjct: 39 HTKAVSSVKFSPNGEWL-ASSSADKLIKIWG------AYDGKFEKTISGHKLGISDVAWS 91 Query: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKL 213 + L+ + +++ D+ SG C L+GH + +++P+ + I+ + S D V++ Sbjct: 92 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV-SGSFDESVRI 150 Query: 214 WDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 WDV+ CL TL AH+ V+ + F DG +++ D R+W+ Sbjct: 151 WDVKTGK-CLKTL---------------PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 194 Query: 274 SSNGE---------NTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSG 324 +++G+ N V++ K N K L T+ +T+ ++ G Sbjct: 195 TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLD-------------NTLKLWDYSKG 241 Query: 325 EQITMLKGHYKTVDCCVFQSNF-----QELYSGSRDCNILAW 361 + + GH K C+F +NF + + SGS D + W Sbjct: 242 KCLKTYTGH-KNEKYCIF-ANFSVTGGKWIVSGSEDNLVYIW 281 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 32/130 (24%), Positives = 58/130 (44%), Gaps = 5/130 (3%) Query: 232 KKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNS 291 K + A++ H V+ + F+ +G L + D +++W + +G+ + K + Sbjct: 27 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK-----FEKTISGH 81 Query: 292 KKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYS 351 K G+ S+ V T+ ++ V SG+ + LKGH V CC F + S Sbjct: 82 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 141 Query: 352 GSRDCNILAW 361 GS D ++ W Sbjct: 142 GSFDESVRIW 151 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 39/178 (21%), Positives = 79/178 (44%), Gaps = 30/178 (16%) Query: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESAN 241 L GH + + +V +SP ++ LA++SAD +K+W ++GK E Sbjct: 36 LAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGA------------YDGK----FEKTI 78 Query: 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKG-LKFTVS 300 + H ++ + ++SD L++ D +++W+ S+G+ C + KG + Sbjct: 79 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK---------CLKTLKGHSNYVFC 129 Query: 301 CGCSSEFVFVPYGS---TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRD 355 C + + + GS ++ ++ V +G+ + L H V F + + S S D Sbjct: 130 CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 187 >6QX9-4B nrPDB Length = 522 Score = 64.3 bits (155), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 54/204 (26%), Positives = 89/204 (43%), Gaps = 35/204 (17%) Query: 98 HRYSVETVQWYPHDTGMFTSSS-FDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKH 156 H V V W+P +G F ++ +D++ ++WD + ++ + E + Sbjct: 322 HTVRVARVMWHP--SGRFLGTTCYDRSWRLWDLEAQE--EILHQEGHSMGVYDIAFHQDG 377 Query: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 L G ++ DL++G C L+GH +EI +++SP Y +AT S D+ K+WD+ Sbjct: 378 SLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPN-GYHIATGSGDNTCKVWDL 436 Query: 217 RRASGCLITLDQHN----GKKSQAVESA--------NTA----------------HNGKV 248 R+ C+ T+ H G K + + NTA H GKV Sbjct: 437 RQRR-CVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKV 495 Query: 249 NGLCFTSDGLHLLTVGTDNRMRLW 272 GL +SDG + T D +LW Sbjct: 496 MGLDISSDGQLIATCSYDRTFKLW 519 Score = 31.6 bits (70), Expect = 0.68, Method: Compositional matrix adjust. Identities = 35/163 (21%), Positives = 63/163 (38%), Gaps = 22/163 (13%) Query: 201 ILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHL 260 + T D+ ++WD+R C++ L+ H ++ G+ F+ +G H+ Sbjct: 379 LAGTGGLDAFGRVWDLRTGR-CIMFLE---------------GHLKEIYGINFSPNGYHI 422 Query: 261 LTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFV-PYGSTIAVY 319 T DN ++W+ + V N G+KF G F+ Y +T ++ Sbjct: 423 ATGSGDNTCKVWDLR--QRRCVYTIPAHQNLVTGVKFEPIHG---NFLLTGAYDNTAKIW 477 Query: 320 TVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWV 362 T + L GH V S+ Q + + S D W+ Sbjct: 478 THPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWM 520 >6HQA-B nrPDB Length = 722 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 67/245 (27%), Positives = 109/245 (44%), Gaps = 45/245 (18%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H G + +D P + RY++S D + L+ L+ YTC V G H S Sbjct: 452 HSGAVYGVDFSP-DNRYLISCSEDKTVRLWSLDT------YTC-LVSYKG------HSSS 497 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF----NFEETVYSHHMSPVSTKHC 157 V V++ P F ++S D+T ++W + + +F N + V H P ST Sbjct: 498 VWDVKFSPMG-HYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFH---PNST--- 550 Query: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEI--LAVSWSPRYDYILATASADSRVKLWD 215 + G+ ++ D+ G C + GH I LAVS R+ LA+A DS V LWD Sbjct: 551 YLFTGSSDKTARMWDIARGECVRVFMGHSGAINCLAVSPDGRW---LASAGEDSVVCLWD 607 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 + ++G I + +G+ S + L F+ +G L++ G DN +R+W+ Sbjct: 608 I--STGRRIKAMRGHGRSS-------------IYSLAFSREGTVLVSTGADNSVRVWDVK 652 Query: 276 NGENT 280 N+ Sbjct: 653 KNTNS 657 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 43/166 (25%), Positives = 75/166 (45%), Gaps = 10/166 (6%) Query: 201 ILATASADSRVKLWDVRRAS-GCLITLDQHNGKKSQAVESANT----AHNGKVNGLCFTS 255 ++A+ DS +KLW + + L+ D +N + + V + H+G V G+ F+ Sbjct: 404 MVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSP 463 Query: 256 DGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGST 315 D +L++ D +RLW S + LV+Y K ++S +KF+ F + T Sbjct: 464 DNRYLISCSEDKTVRLW-SLDTYTCLVSY-KGHSSSVWDVKFS---PMGHYFATASHDQT 518 Query: 316 IAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 +++ + + GH VDC F N L++GS D W Sbjct: 519 ARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMW 564 Score = 35.0 bits (79), Expect = 0.056, Method: Compositional matrix adjust. Identities = 41/186 (22%), Positives = 74/186 (39%), Gaps = 28/186 (15%) Query: 179 SHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVE 238 S L GH + V +SP Y++ + S D V+LW + + CL++ Sbjct: 446 SRRLVGHSGAVYGVDFSPDNRYLI-SCSEDKTVRLWSLDTYT-CLVSY------------ 491 Query: 239 SANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFT 298 H+ V + F+ G + T D RLW+ + + G + N ++F Sbjct: 492 ---KGHSSSVWDVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHL--NDVDCVEF- 545 Query: 299 VSCGCSSEFVFVPYGS---TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRD 355 +S ++F GS T ++ + GE + + GH ++C + + L S D Sbjct: 546 ---HPNSTYLFT--GSSDKTARMWDIARGECVRVFMGHSGAINCLAVSPDGRWLASAGED 600 Query: 356 CNILAW 361 + W Sbjct: 601 SVVCLW 606 >5NNZ-B nrPDB Length = 415 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 52/224 (23%), Positives = 100/224 (44%), Gaps = 33/224 (14%) Query: 115 FTSSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMS-PVSTKHCLVAVGTRGPKVQLCD 172 F + S+D+T K+WDT + + + VY+ + P K +A G+ +L Sbjct: 107 FITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDK---IATGSFDKTCKLWS 163 Query: 173 LKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGK 232 +++G C H +GH EI+ +S++P+ ++AT S D+ KLWD++ NG+ Sbjct: 164 VETGKCYHTFRGHTAEIVCLSFNPQ-STLVATGSMDTTAKLWDIQ------------NGE 210 Query: 233 KSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSK 292 + + H+ ++ L F + G ++T D+ + +W++ G + G S Sbjct: 211 EVYTLR----GHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISS 266 Query: 293 KGLKFTVSCGCSSEFVFVPYGS---TIAVYTVYSGEQITMLKGH 333 + S + GS T ++ +G+ + L GH Sbjct: 267 ASFNWDCS--------LILTGSMDKTCKLWDATNGKCVATLTGH 302 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 63/274 (22%), Positives = 110/274 (40%), Gaps = 52/274 (18%) Query: 14 DPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDL 73 D + + T ++ +E K R H I L P + + +G D L+D+ Sbjct: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNP-QSTLVATGSMDTTAKLWDI 206 Query: 74 ENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG-MFTSSSFDKTLKVWDTNTL 132 +N + YT + +S E + + +G + SFD T+ VWD +T Sbjct: 207 QNG--EEVYTLRG-------------HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTG 251 Query: 133 QTADVFNFEETVYSHHMSPVSTKH-----CLVAVGTRGPKVQLCDLKSGSCSHILQGHRQ 187 + ++ H + +S+ L+ G+ +L D +G C L GH Sbjct: 252 RKVNIL-------IGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDD 304 Query: 188 EILAVSWSPRYDY---ILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAH 244 EIL +DY ++ATASAD +++ C+ L+ H Sbjct: 305 EIL----DSCFDYTGKLIATASADGTARIFSAA-TRKCIAKLE---------------GH 344 Query: 245 NGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 G+++ + F G HLLT +D R+W++ G+ Sbjct: 345 EGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQ 378 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 50/224 (22%), Positives = 83/224 (37%), Gaps = 28/224 (12%) Query: 144 VYSHHMSPVS------TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPR 197 V H+ P++ + C + G+ +L D SG + L+GHR + A++++ Sbjct: 87 VLKAHILPLTNVALNKSGSCFI-TGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145 Query: 198 YDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDG 257 Y +AT S D KLW V C T H ++ L F Sbjct: 146 YGDKIATGSFDKTCKLWSVETGK-CYHTF---------------RGHTAEIVCLSFNPQS 189 Query: 258 LHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIA 317 + T D +LW+ NGE G + L F S + + T+ Sbjct: 190 TLVATGSMDTTAKLWDIQNGEEVYTLRGH--SAEIISLSFNTS---GDRIITGSFDHTVV 244 Query: 318 VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 V+ +G ++ +L GH + F + + +GS D W Sbjct: 245 VWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW 288 Score = 33.1 bits (74), Expect = 0.24, Method: Compositional matrix adjust. Identities = 14/53 (26%), Positives = 31/53 (58%), Gaps = 1/53 (1%) Query: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLW 214 G+ ++ D ++G C +L+GH EI + +++ + + I+ T S D+ ++W Sbjct: 363 GSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGN-IVITGSKDNTCRIW 414 >4N14-A nrPDB Length = 314 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 63/267 (23%), Positives = 117/267 (43%), Gaps = 33/267 (12%) Query: 93 DHPDVHR-YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSP 151 D P++ Y + V W +G + + D ++ +W ++ + E+ ++S Sbjct: 14 DAPEIRNDYYLNLVDW---SSGNVLAVALDNSVYLWSASSGDILQLLQMEQP--GEYISS 68 Query: 152 VS--TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADS 209 V+ + +AVGT +VQL D++ + H + ++SW+ YIL++ S Sbjct: 69 VAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSG 125 Query: 210 RVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRM 269 + DVR A + TL + H+ +V GL + DG HL + G DN + Sbjct: 126 HIHHHDVRVAEHHVATL---------------SGHSQEVCGLRWAPDGRHLASGGNDNLV 170 Query: 270 RLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGST---IAVYTVYSGEQ 326 +W S+ GE V + + +K C S + G++ I ++ V SG Sbjct: 171 NVWPSAPGEGGWVPL-QTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGAC 229 Query: 327 ITMLKGHYKTVDCCVFQS-NFQELYSG 352 ++ + H + C + S +++EL SG Sbjct: 230 LSAVDAHSQV--CSILWSPHYKELISG 254 Score = 34.7 bits (78), Expect = 0.076, Method: Compositional matrix adjust. Identities = 49/254 (19%), Positives = 87/254 (34%), Gaps = 56/254 (22%) Query: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKA-----------VCSIGRDHPDVHRYSVE 103 EG Y+ G S + L+D++ R T + + S G +H + V Sbjct: 74 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVR 133 Query: 104 T-----------------VQWYPHDTGMFTSSSFDKTLKVWDTNT-------LQTADVFN 139 ++W P D S D + VW + LQT Sbjct: 134 VAEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQT--FTQ 190 Query: 140 FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRY- 198 + V + P + GT +++ ++ SG+C + H Q + ++ WSP Y Sbjct: 191 HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYK 249 Query: 199 DYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGL 258 + I A +++ +W + A + H +V L + DG Sbjct: 250 ELISGHGFAQNQLVIWKY----------------PTMAKVAELKGHTSRVLSLTMSPDGA 293 Query: 259 HLLTVGTDNRMRLW 272 + + D +RLW Sbjct: 294 TVASAAADETLRLW 307 >6QX9-5O nrPDB Length = 357 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 75/325 (23%), Positives = 130/325 (40%), Gaps = 52/325 (16%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H G + P G + S G D +I+L+++ +Y T K H + Sbjct: 65 HEGEVYCCKFHP-NGSTLASAGFDRLILLWNVYGDC-DNYATLKG-----------HSGA 111 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 V + Y D M S+S DKT+ VWD+ T + T + + P LV Sbjct: 112 VMELH-YNTDGSMLFSASTDKTVAVWDSETGERVKRLK-GHTSFVNSCYPARRGPQLVCT 169 Query: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASG 221 G+ V+L D++ + Q Q +LAV+++ D I+ + D+ +K+WD+R+ Sbjct: 170 GSDDGTVKLWDIRKKAAIQTFQNTYQ-VLAVTFNDTSDQII-SGGIDNDIKVWDLRQ--- 224 Query: 222 CLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN----SSNG 277 + H V GL +S+G +LL+ DN +R+W+ + Sbjct: 225 -------------NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKE 271 Query: 278 ENTLVNYGKVCNNSKKGLKFT-------VSCGCSSEFVFVPYGSTIAVYTVYSGEQITML 330 + G V N K L+ + ++ G + FV+ V+ S + L Sbjct: 272 RCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVY--------VWDTTSRRILYKL 323 Query: 331 KGHYKTVDCCVFQSNFQELYSGSRD 355 GH +++ F + + S S D Sbjct: 324 PGHAGSINEVAFHPDEPIIISASSD 348 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 40/186 (21%), Positives = 70/186 (37%), Gaps = 31/186 (16%) Query: 181 ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA 240 +L GH E+ + P LA+A D + LW+V TL Sbjct: 61 LLSGHEGEVYCCKFHPN-GSTLASAGFDRLILLWNVYGDCDNYATL-------------- 105 Query: 241 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTL-----VNYGKVCNNSKKGL 295 H+G V L + +DG L + TD + +W+S GE ++ C +++G Sbjct: 106 -KGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP 164 Query: 296 KFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRD 355 + C S + T+ ++ + I + Y+ + F ++ SG D Sbjct: 165 QLV--CTGSDD-------GTVKLWDIRKKAAIQTFQNTYQVL-AVTFNDTSDQIISGGID 214 Query: 356 CNILAW 361 +I W Sbjct: 215 NDIKVW 220 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 15/35 (42%), Positives = 16/35 (45%) Query: 327 ITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 I +L GH V CC F N L S D IL W Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLW 93 >5GAN-H nrPDB Length = 465 Score = 61.2 bits (147), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 66/263 (25%), Positives = 112/263 (42%), Gaps = 37/263 (14%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H G I +D P M+S DG+I + N V H Sbjct: 217 HVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVG---------HERR 267 Query: 102 VETVQWYPHDTGMFT-SSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTKHCLV 159 + V+++P +G F S+S D T ++WD +T Q + ++ V+S LV Sbjct: 268 ISDVKYHP--SGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFS---LSFQCDGSLV 322 Query: 160 AVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRA 219 G L D++SGS L GH + I V+WSP Y +AT D + +WD+R+ Sbjct: 323 CSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPN-GYQVATGGGDGIINVWDIRK- 380 Query: 220 SGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD--GLHLLTVGTDNRMRLWNSSNG 277 + G+ +Q + AH V + F+ + G L++ G DN + +++S Sbjct: 381 --------RDEGQLNQIL-----AHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSS--- 424 Query: 278 ENTLVNYGKVCNNSKKGLKFTVS 300 +T + G + ++ K + +S Sbjct: 425 -DTWLKMGSLAGHTDKIISLDIS 446 >1NR0-A nrPDB Length = 611 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 52/217 (23%), Positives = 91/217 (41%), Gaps = 25/217 (11%) Query: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGM 114 +G S G DG IVLY+ + ++ + ++ ++ H SV + W P T + Sbjct: 201 DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA------HSGSVFGLTWSPDGTKI 254 Query: 115 FTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLK 174 S+S DKT+K+W+ TL+ + + + TK LV++ G + + + Sbjct: 255 -ASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANG-FINFVNPE 312 Query: 175 SGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKS 234 GS + GH + I A+S S L +A A+ + WD+ + D Sbjct: 313 LGSIDQVRYGHNKAITALS-SSADGKTLFSADAEGHINSWDISTGISNRVFPD------- 364 Query: 235 QAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL 271 H + G+ TS G L TV D+ +++ Sbjct: 365 --------VHATMITGIKTTSKG-DLFTVSWDDHLKV 392 Score = 35.0 bits (79), Expect = 0.058, Method: Compositional matrix adjust. Identities = 41/189 (21%), Positives = 76/189 (40%), Gaps = 43/189 (22%) Query: 124 LKVWDTNTLQTADVFNFEETVYSHHMSPVS---TKHCLVAVGT---RGPKVQLCDLKSGS 177 +++WDT QT + V+S + +S + AVG R V L D +G+ Sbjct: 83 VRIWDTT--QTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFD--TGT 138 Query: 178 CSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD-------------------VRR 218 + L G + + +V + P + + + S D+ V +++ VR Sbjct: 139 SNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRY 198 Query: 219 -----------ASGCLITLDQHNGKKSQAVES---ANTAHNGKVNGLCFTSDGLHLLTVG 264 G ++ + +G K+ E N AH+G V GL ++ DG + + Sbjct: 199 NPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASAS 258 Query: 265 TDNRMRLWN 273 D +++WN Sbjct: 259 ADKTIKIWN 267 Score = 33.5 bits (75), Expect = 0.15, Method: Compositional matrix adjust. Identities = 24/89 (26%), Positives = 45/89 (50%), Gaps = 15/89 (16%) Query: 185 HRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAH 244 H ++ VSWSP + LAT S D+ V +W++ + S I + K + A+ S Sbjct: 535 HTAKVACVSWSPD-NVRLATGSLDNSVIVWNMNKPSDHPIII-----KGAHAMSS----- 583 Query: 245 NGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 VN + + ++ +++ G D+ ++ WN Sbjct: 584 ---VNSVIWLNE-TTIVSAGQDSNIKFWN 608 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 31/117 (26%), Positives = 51/117 (43%), Gaps = 15/117 (12%) Query: 158 LVAVGTRGPKVQLCDLKSGSCSHILQ-GHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 VAVG + KV + L S S + H EI +V++S +++AT D K+ Sbjct: 462 FVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVAT---DQSRKVIPY 518 Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 A+ + A ++ T H KV + ++ D + L T DN + +WN Sbjct: 519 SVANNFEL-----------AHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWN 564 >4E5Z-B nrPDB Length = 436 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 51/184 (27%), Positives = 88/184 (47%), Gaps = 20/184 (10%) Query: 101 SVETVQWYPHDTGMFTSSSFDKTLKVWD--TNTLQTADVFNFEETVYSHHMS-PVSTKHC 157 S+ +++ P +T F +SS + T ++ D N L+ VF +T+ S VS Sbjct: 166 SITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILR---VFASSDTINIWFCSLDVSASSR 222 Query: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 +V G V L ++ + L+ H++++ V+ +P D+ LATAS D VK+WD+R Sbjct: 223 MVVTGDNVGNVILLNMDGKELWN-LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR 281 Query: 218 RASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNG 277 + G +A + H VN CF+ DG LLT + +R++++S Sbjct: 282 QVRG-------------KASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQW 328 Query: 278 ENTL 281 + L Sbjct: 329 DCPL 332 >5YZG-W nrPDB Length = 579 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 46/188 (24%), Positives = 73/188 (38%), Gaps = 30/188 (15%) Query: 180 HILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVES 239 H+ GH + + AV P ++L + S D ++KLW+V CL T Sbjct: 282 HVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTF------------- 328 Query: 240 ANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE------NTLVNYGKVCNNSKK 293 H+ V +CF + G L+ D ++LW++ G+ N V Y C Sbjct: 329 --IGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPY---C----- 378 Query: 294 GLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGS 353 +KF + FV I + + SGE + H V+ VF + S S Sbjct: 379 -VKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS 437 Query: 354 RDCNILAW 361 D ++ W Sbjct: 438 DDKSLRVW 445 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 55/231 (23%), Positives = 90/231 (38%), Gaps = 22/231 (9%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H G++ + + P+ G +LS D I L+++ R C IG H + Sbjct: 287 HTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERR-----CLRTF-IG------HSKA 334 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 V + + T F S+++D+ LK+WDT T Q F + Y +P K L Sbjct: 335 VRDICFNTAGT-QFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVA 393 Query: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADS-RVKLWDVRRAS 220 G K+ D++SG H + + + ++T+ S RV WD+ Sbjct: 394 GMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDF 453 Query: 221 GCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL 271 + H ++ + + NGK L S +L G NR RL Sbjct: 454 KYIAEPSMH------SMPAVTLSPNGK--WLACQSMDNQILIFGAQNRFRL 496 Score = 30.8 bits (68), Expect = 1.0, Method: Compositional matrix adjust. Identities = 16/71 (22%), Positives = 31/71 (43%), Gaps = 13/71 (18%) Query: 58 YMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTS 117 Y++SG +G + ++D + + S + IG W+PH+T + Sbjct: 522 YVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIG-------------AVWHPHETSKVIT 568 Query: 118 SSFDKTLKVWD 128 +D +K+WD Sbjct: 569 CGWDGLIKLWD 579 >6QDV-o nrPDB Length = 513 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 46/188 (24%), Positives = 73/188 (38%), Gaps = 30/188 (15%) Query: 180 HILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVES 239 H+ GH + + AV P ++L + S D ++KLW+V CL T Sbjct: 216 HVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTF------------- 262 Query: 240 ANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE------NTLVNYGKVCNNSKK 293 H+ V +CF + G L+ D ++LW++ G+ N V Y C Sbjct: 263 --IGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPY---C----- 312 Query: 294 GLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGS 353 +KF + FV I + + SGE + H V+ VF + S S Sbjct: 313 -VKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS 371 Query: 354 RDCNILAW 361 D ++ W Sbjct: 372 DDKSLRVW 379 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 55/231 (23%), Positives = 90/231 (38%), Gaps = 22/231 (9%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H G++ + + P+ G +LS D I L+++ R C IG H + Sbjct: 221 HTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERR-----CLRTF-IG------HSKA 268 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 V + + T F S+++D+ LK+WDT T Q F + Y +P K L Sbjct: 269 VRDICFNTAGT-QFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVA 327 Query: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADS-RVKLWDVRRAS 220 G K+ D++SG H + + + ++T+ S RV WD+ Sbjct: 328 GMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDF 387 Query: 221 GCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL 271 + H ++ + + NGK L S +L G NR RL Sbjct: 388 KYIAEPSMH------SMPAVTLSPNGK--WLACQSMDNQILIFGAQNRFRL 430 Score = 31.2 bits (69), Expect = 0.93, Method: Compositional matrix adjust. Identities = 16/71 (22%), Positives = 31/71 (43%), Gaps = 13/71 (18%) Query: 58 YMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTS 117 Y++SG +G + ++D + + S + IG W+PH+T + Sbjct: 456 YVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIG-------------AVWHPHETSKVIT 502 Query: 118 SSFDKTLKVWD 128 +D +K+WD Sbjct: 503 CGWDGLIKLWD 513 >5Z56-q nrPDB Length = 504 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 82/335 (24%), Positives = 123/335 (36%), Gaps = 94/335 (28%) Query: 31 ELNKDRDVER---IHGG---GINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTC 84 EL+K R V +H GI LD+ P + +L+GG+D +V++D SS Q T Sbjct: 203 ELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFD--KSSEQILATL 260 Query: 85 KAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETV 144 K H V +V ++P +F S+S D T+++W V E+ Sbjct: 261 KG-----------HTKKVTSVVFHPSQDLVF-SASPDATIRIWSVPNASCVQVVRAHESA 308 Query: 145 ---YSHH----------------MSPVSTKHCLVAV-----------------------G 162 S H S + T L V G Sbjct: 309 VTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTG 368 Query: 163 TRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGC 222 T ++++ DLK + GH I ++++S Y LATA+ DS VKLWD+R+ Sbjct: 369 TMDSQIKIWDLKERTNVANFPGHSGPITSIAFS-ENGYYLATAADDSSVKLWDLRKLKN- 426 Query: 223 LITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLV 282 TL N N +V L F G +L GTD ++ Sbjct: 427 FKTLQLDN--------------NFEVKSLIFDQSGTYLALGGTDVQIY------------ 460 Query: 283 NYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIA 317 +C + L FT G ++ F + IA Sbjct: 461 ----ICKQWTEILHFTEHSGLTTGVAFGHHAKFIA 491 Score = 31.2 bits (69), Expect = 0.74, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 22/46 (47%) Query: 316 IAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 + V+ S + + LKGH K V VF + ++S S D I W Sbjct: 246 VVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291 >4LG8-A nrPDB Length = 354 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 81/335 (24%), Positives = 124/335 (37%), Gaps = 94/335 (28%) Query: 31 ELNKDRDVER---IHGG---GINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTC 84 EL+K R V +H GI LD+ P + +L+GG+D +V++D SS Q T Sbjct: 53 ELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFD--KSSEQILATL 110 Query: 85 KAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEE-- 142 K H V +V ++P +F S+S D T+++W V E Sbjct: 111 KG-----------HTKKVTSVVFHPSQDLVF-SASPDATIRIWSVPNASCVQVVRAHESA 158 Query: 143 -TVYSHH----------------MSPVSTKHCLVAV-----------------------G 162 T S H S + T L V G Sbjct: 159 VTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTG 218 Query: 163 TRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGC 222 T ++++ DLK + GH I ++++S Y LATA+ DS VKLWD+R Sbjct: 219 TMDSQIKIWDLKERTNVANFPGHSGPITSIAFSEN-GYYLATAADDSSVKLWDLR----- 272 Query: 223 LITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLV 282 K + ++ +N +V L F G +L GTD ++ Sbjct: 273 ----------KLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIY------------ 310 Query: 283 NYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIA 317 +C + L FT G ++ F + IA Sbjct: 311 ----ICKQWTEILHFTEHSGLTTGVAFGHHAKFIA 341 Score = 31.6 bits (70), Expect = 0.66, Method: Compositional matrix adjust. Identities = 25/83 (30%), Positives = 38/83 (45%), Gaps = 3/83 (3%) Query: 316 IAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW-VP--SLYEPVPDD 372 + V+ S + + LKGH K V VF + ++S S D I W VP S + V Sbjct: 96 VVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAH 155 Query: 373 DETTTKSQLNPAFEDAWSSSDEE 395 + T L+ + SSSD++ Sbjct: 156 ESAVTGLSLHATGDYLLSSSDDQ 178 >5Y88-O nrPDB Length = 451 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 87/211 (41%), Gaps = 40/211 (18%) Query: 109 PHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMS----PVSTKHCLVAVGTR 164 P D F + S D T+KVWD T + + T+ H M+ VS +H + + Sbjct: 149 PVDNEWFITGSNDTTMKVWDLATGK------LKTTLAGHVMTVRDVAVSDRHPYLFSVSE 202 Query: 165 GPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLI 224 V+ DL+ GH + VS P D I ATA DS +KLWD+ R +I Sbjct: 203 DKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLI-ATAGRDSVIKLWDM-RTRIPVI 260 Query: 225 TLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNY 284 TL H G +N + T +++ TD +RLW+ G+ Sbjct: 261 TL---------------VGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTM---- 301 Query: 285 GKVCNNSKKGLK--------FTVSCGCSSEF 307 KV + K+ ++ F+V+ C+ + Sbjct: 302 -KVLTHHKRSVRATALHPKEFSVASACTDDI 331 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 81/351 (23%), Positives = 132/351 (37%), Gaps = 68/351 (19%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H G + + I+PV+ + ++G +D + ++DL ++ + D H Y Sbjct: 138 HLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSDRHPY- 196 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHC---- 157 S S DKT+K WD Q Y H+S V T Sbjct: 197 -------------LFSVSEDKTVKCWDLEKNQII-------RDYYGHLSGVRTVSIHPTL 236 Query: 158 -LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 L+A R ++L D+++ L GH+ I V +P D + ++S D+ V+LWDV Sbjct: 237 DLIATAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTP-VDPQVVSSSTDATVRLWDV 295 Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN 276 GK + + T H V + + TD+ +R W + Sbjct: 296 V------------AGKTMKVL----THHKRSVRATALHPKEFSVASACTDD-IRSWGLAE 338 Query: 277 GENTLVNYGKVCNNSKKGLKFTVSC---------GCSSEFVFVPYGSTIAVYTVYSGEQI 327 G + L N+ + K G+ T+S G + F Y S ++ + E + Sbjct: 339 G-SLLTNF----ESEKTGIINTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMV 393 Query: 328 TMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTK 378 L+G ++V C F L +G D +I W DET TK Sbjct: 394 GSLEGE-RSVLCSTFDKTGLRLITGEADKSIKIW---------KQDETATK 434 >1VYH-C nrPDB Length = 410 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 58/241 (24%), Positives = 93/241 (38%), Gaps = 53/241 (21%) Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMF 115 G+ + S +D I L+D + + C G DH +V +V P + Sbjct: 162 GKLLASCSADMTIKLWDFQG------FECIRTMH-GHDH------NVSSVSIMP-NGDHI 207 Query: 116 TSSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLK 174 S+S DKT+K+W+ T F E V M + L+A + V++ + Sbjct: 208 VSASRDKTIKMWEVQTGYCVKTFTGHREWV---RMVRPNQDGTLIASCSNDQTVRVWVVA 264 Query: 175 SGSCSHILQGHRQEILAVSWSPRYDY-------------------ILATASADSRVKLWD 215 + C L+ HR + +SW+P Y L + S D +K+WD Sbjct: 265 TKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWD 324 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 V CL+TL H+ V G+ F S G +L+ D +R+W+ Sbjct: 325 V-STGMCLMTL---------------VGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYK 368 Query: 276 N 276 N Sbjct: 369 N 369 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 72/292 (24%), Positives = 114/292 (39%), Gaps = 61/292 (20%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSH--HMSPVSTK 155 HR V V ++P + M S+S D T+KVWD T +FE T+ H + +S Sbjct: 107 HRSPVTRVIFHPVFSVM-VSASEDATIKVWDYET------GDFERTLKGHTDSVQDISFD 159 Query: 156 HC--LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKL 213 H L+A + ++L D + C + GH + +VS P D+I++ AS D +K+ Sbjct: 160 HSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVS-ASRDKTIKM 218 Query: 214 WDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 W+V+ C+ T T H V + DG + + D +R+W Sbjct: 219 WEVQTGY-CVKTF---------------TGHREWVRMVRPNQDGTLIASCSNDQTVRVW- 261 Query: 274 SSNGENTLVNYGKVCNNSKKGLKFTVSC--------------GCSSEF-------VFVPY 312 V K C + + V C SE F+ Sbjct: 262 --------VVATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS 313 Query: 313 GS---TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 GS TI ++ V +G + L GH V +F S + + S + D + W Sbjct: 314 GSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 57/251 (22%), Positives = 101/251 (40%), Gaps = 57/251 (22%) Query: 141 EETVYSHHMSPVS--TKHCLVAV---GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 195 E+ S H SPV+ H + +V + +++ D ++G L+GH + +S Sbjct: 100 EKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDIS-- 157 Query: 196 PRYDY---ILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLC 252 +D+ +LA+ SAD +KLWD + C+ T+ H+ HN V+ + Sbjct: 158 --FDHSGKLLASCSADMTIKLWDFQ-GFECIRTMHGHD-------------HN--VSSVS 199 Query: 253 FTSDGLHLLTVGTDNRMRLWNSSNGE--NTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFV 310 +G H+++ D +++W G T + + + T+ CS++ Sbjct: 200 IMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSND---- 255 Query: 311 PYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQ-----SNFQE---------------LY 350 T+ V+ V + E L+ H V+C + S+ E L Sbjct: 256 ---QTVRVWVVATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLL 312 Query: 351 SGSRDCNILAW 361 SGSRD I W Sbjct: 313 SGSRDKTIKMW 323 >5OQL-J nrPDB Length = 912 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 88/207 (42%), Gaps = 33/207 (15%) Query: 47 NTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQ 106 N LD P +++SG D + D+ RQ K S+ R H + + Sbjct: 501 NPLDHPPA---FLISGSQDRFVQKRDI---PRQLQKGGKLTSSLRRL---AHDKDINALD 551 Query: 107 WYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTK---------- 155 P+ +F S+S DKT+K+WD L+ + + V++ +P++T Sbjct: 552 ISPNGK-LFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVS 610 Query: 156 -HCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSW--SPRYDYI------LATAS 206 +V G+ ++L +L +C +GH +L V W R D I A+A Sbjct: 611 GRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAG 670 Query: 207 ADSRVKLWDVRRA-SGCLITLDQHNGK 232 AD+ VK+WD + C TLD H + Sbjct: 671 ADTLVKVWDANTGETEC--TLDNHEDR 695 >6ID0-T nrPDB Length = 514 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 59/229 (25%), Positives = 88/229 (38%), Gaps = 49/229 (21%) Query: 58 YMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRD-HPDVHRYSVETVQWYPHDTGMFT 116 Y+ S G D + +DLE + +Y G D HP + + Sbjct: 260 YLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI---------------DVLV 304 Query: 117 SSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVA-----VGTRGPKVQLC 171 + S D T ++WD T + S H + V+T C A G+ ++L Sbjct: 305 TCSRDSTARIWDVRTKASVHTL-------SGHTNAVATVRCQAAEPQIITGSHDTTIRLW 357 Query: 172 DLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNG 231 DL +G L H++ + AV PR+ Y A+ S D+ +K W + G I Sbjct: 358 DLVAGKTRVTLTNHKKSVRAVVLHPRH-YTFASGSPDN-IKQW--KFPDGSFI------- 406 Query: 232 KKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDN-RMRLWNSSNGEN 279 + HN +N L SDG +L G DN M LW+ G N Sbjct: 407 -------QNLSGHNAIINTLTVNSDG--VLVSGADNGTMHLWDWRTGYN 446 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 40/184 (21%), Positives = 71/184 (38%), Gaps = 28/184 (15%) Query: 181 ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA 240 ++ GH + ++ P + + T SAD +K+WD+ ASG L + + Sbjct: 199 VISGHLGWVRCIAVEPGNQWFV-TGSADRTIKIWDL--ASGKL--------------KLS 241 Query: 241 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS 300 T H V G+ ++ +L + G D +++ W+ + Y KV + L Sbjct: 242 LTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWD--------LEYNKVIRHYHGHLSAVYG 293 Query: 301 CGCSSE---FVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCN 357 V ST ++ V + + L GH V Q+ ++ +GS D Sbjct: 294 LDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTT 353 Query: 358 ILAW 361 I W Sbjct: 354 IRLW 357 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 46/183 (25%), Positives = 72/183 (39%), Gaps = 39/183 (21%) Query: 115 FTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGP-------- 166 F + S D+T+K+WD + + + + H+S V V V TR P Sbjct: 219 FVTGSADRTIKIWDLASGKL-------KLSLTGHISTVRG----VIVSTRSPYLFSCGED 267 Query: 167 -KVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLIT 225 +V+ DL+ GH + + P D +L T S DS ++WDV R + T Sbjct: 268 KQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTID-VLVTCSRDSTARIWDV-RTKASVHT 325 Query: 226 LDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEN--TLVN 283 L H N C ++ ++T D +RLW+ G+ TL N Sbjct: 326 LSGHT--------------NAVATVRCQAAEP-QIITGSHDTTIRLWDLVAGKTRVTLTN 370 Query: 284 YGK 286 + K Sbjct: 371 HKK 373 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 46/197 (23%), Positives = 74/197 (37%), Gaps = 29/197 (14%) Query: 168 VQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLD 227 +++ DL SG L GH + V S R Y+ + D +VK WD+ + Sbjct: 228 IKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGE-DKQVKCWDLEYNK----VIR 282 Query: 228 QHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN--SSNGENTLVNYG 285 ++G H V GL L+T D+ R+W+ + +TL + Sbjct: 283 HYHG------------HLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHT 330 Query: 286 KVCNNSKKGLKFTVSC-GCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQS 344 TV C + + + +TI ++ + +G+ L H K+V V Sbjct: 331 NAVA--------TVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHP 382 Query: 345 NFQELYSGSRDCNILAW 361 SGS D NI W Sbjct: 383 RHYTFASGSPD-NIKQW 398 >4XYI-A nrPDB Length = 430 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 15/109 (13%) Query: 175 SGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKS 234 S S S ++ H Q + V+++P DY+LATASAD V LWD+RR + L TL+ G + Sbjct: 270 SSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRLHTLE---GHED 326 Query: 235 QAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN-GENTLV 282 + + H+ + L+T TD R+ +W+ S GE V Sbjct: 327 EVYNVQWSPHDEPI-----------LVTSSTDRRVCVWDLSKIGEEQTV 364 Score = 44.7 bits (104), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 35/177 (19%), Positives = 68/177 (38%), Gaps = 46/177 (25%) Query: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 + H +N + P + + +D + L+DL + Q +T + H Sbjct: 278 KAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLN-QRLHTLEG-----------HE 325 Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLV 159 V VQW PHD + +SS D+ + VWD + + Sbjct: 326 DEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKI--------------------------- 358 Query: 160 AVGTRGPKVQLCDLKSGSCSHILQ--GHRQEILAVSWSPRYDYILATASADSRVKLW 214 G + + D + G+ + GH + +SW+P ++LA+ + D+ +++W Sbjct: 359 -----GEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIW 410 >5FL8-q nrPDB Length = 515 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 67/291 (23%), Positives = 115/291 (39%), Gaps = 52/291 (17%) Query: 109 PHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEET-VYSHHMSPVSTKHCLVAVGTRGPK 167 PH + + + D T ++WD +T V SP ++A G+ Sbjct: 153 PHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDGE---VIATGSMDNT 209 Query: 168 VQLCDLKSGSC-SHILQGHRQEILAVSWSPRY------DYILATASADSRVKLWD-VRRA 219 ++L D KSG C L+GH + I ++SW P + LA++S D +K+WD V R Sbjct: 210 IRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRV 269 Query: 220 SGCLITLDQH----------------NGKKSQAVESANTAHNGK-VNGLCFTSDGLHLLT 262 C T+ H +G + V + G+ +N L + ++ L+ Sbjct: 270 --CQYTMSGHTNSVSCVKWGGQGLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLS 327 Query: 263 VGTDNRMRLWN-----------SSNGENTLVNYGKVCNNSKKGLKFTVSCGCS-SEFVFV 310 + TD +R+ + L NY K+C + + V+ + F++ Sbjct: 328 LSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWN 387 Query: 311 PYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 P ST + I + GH K V+ F + + + S S D +I W Sbjct: 388 PLKST---------KPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLW 429 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 51/223 (22%), Positives = 96/223 (43%), Gaps = 30/223 (13%) Query: 131 TLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEIL 190 T ++ + T+ +P ++ + G ++ CD ++ H L+GH +L Sbjct: 133 TRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPM--HTLKGHYNWVL 190 Query: 191 AVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNG 250 VSWSP + ++AT S D+ ++LWD K Q + A H+ + Sbjct: 191 CVSWSPDGE-VIATGSMDNTIRLWD---------------PKSGQCLGDALRGHSKWITS 234 Query: 251 LCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNY---GKVCNNSKKGLKFTVSC---GCS 304 L + + +HL+ G+ R+ SS+ + T+ + +VC + G +VSC G Sbjct: 235 LSW--EPIHLVKPGSKPRLA---SSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQ 289 Query: 305 SEFVFVPYGSTIAVYTVYS-GEQITMLKGHYKTVDCCVFQSNF 346 + T+ V+ + S G I +LK H V+ +++ Sbjct: 290 GLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDY 332 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 76/395 (19%), Positives = 133/395 (33%), Gaps = 98/395 (24%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 HG I P M++G D ++D + ++ +T K H Sbjct: 142 HGSTILCSAFAPHTSSRMVTGAGDNTARIWDCD--TQTPMHTLKG-----------HYNW 188 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ-TADVFNFEETVYS-------HHMSPVS 153 V V W P D + + S D T+++WD + Q D + H + P S Sbjct: 189 VLCVSWSP-DGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGS 247 Query: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKL 213 +A ++ +++ D S C + + GH + V W + +L + S D V++ Sbjct: 248 KPR--LASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQG--LLYSGSHDRTVRV 303 Query: 214 WDVRRASGCLITLDQ----------------------HNGKKSQAVESAN---------- 241 WD+ C+ L H GKK E A Sbjct: 304 WDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKI 363 Query: 242 -----------------------------------TAHNGKVNGLCFTSDGLHLLTVGTD 266 T H VN + F+ DG ++++ D Sbjct: 364 CKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFD 423 Query: 267 NRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQ 326 N ++LW+ +G+ G V S + ++ C V +T+ V+ V + + Sbjct: 424 NSIKLWDGRDGKFISTFRGHVA--SVYQVAWSSDCRL---LVSCSKDTTLKVWDVRTRKL 478 Query: 327 ITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 L GH V + + + + SG +D + W Sbjct: 479 SVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 35.0 bits (79), Expect = 0.053, Method: Compositional matrix adjust. Identities = 35/142 (24%), Positives = 60/142 (42%), Gaps = 18/142 (12%) Query: 8 RQTGLEDPLRLRRAESTRRVLGLELNKDRDVERI--HGGGINTLDIEPVEGRYMLSGGSD 65 ++ G + + + ++ L L + + R+ H +N + P +GRY++S D Sbjct: 365 KKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSP-DGRYIVSASFD 423 Query: 66 GVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLK 125 I L+D + S + H SV V W D + S S D TLK Sbjct: 424 NSIKLWDGRDGKFISTFRG-------------HVASVYQVAWS-SDCRLLVSCSKDTTLK 469 Query: 126 VWDTNTLQ-TADVFNFEETVYS 146 VWD T + + D+ ++ VY+ Sbjct: 470 VWDVRTRKLSVDLPGHKDEVYT 491 Score = 28.5 bits (62), Expect = 4.9, Method: Compositional matrix adjust. Identities = 17/60 (28%), Positives = 27/60 (45%) Query: 304 SSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVP 363 SS V +T ++ + + LKGHY V C + + + + +GS D I W P Sbjct: 156 SSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDP 215 >6ELZ-p nrPDB Length = 460 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 53/191 (27%), Positives = 93/191 (48%), Gaps = 21/191 (10%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSH-HMSPVSTKH 156 H VE V + D + S S D T+K WD L TA + T YS ++ +ST + Sbjct: 286 HTAPVEQVIFDSTDNTVGYSVSQDHTIKTWD---LVTARCIDTRTTSYSLLSIAQLSTLN 342 Query: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQ----GHRQEILAVSWSPRYDYILATASADSRVK 212 L+A G+ + L D + G+ S + Q GH+ + ++ P +YIL + S D VK Sbjct: 343 -LLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVK 401 Query: 213 LWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLW 272 +WDVR S + T+ + + + V N KV + + ++ + +++ G D ++++ Sbjct: 402 VWDVRSTS-PMYTITREDKSVQKGV-------NDKVFAVKW-AEKVGIISAGQDKKIQI- 451 Query: 273 NSSNGENTLVN 283 + G+N N Sbjct: 452 --NKGDNIFKN 460 Score = 28.9 bits (63), Expect = 3.7, Method: Compositional matrix adjust. Identities = 47/214 (21%), Positives = 81/214 (37%), Gaps = 45/214 (21%) Query: 168 VQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLIT-- 225 V+ DL SG+ GH I AV + + L +A D ++LW + L + Sbjct: 127 VRTWDL-SGNVQKQYSGHSGPIRAVKYIS--NTRLVSAGNDRTLRLWKTKNDDLKLTSQQ 183 Query: 226 ---------LDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN 276 ++ +GK +E H V + SD +L+ DN + W++ Sbjct: 184 QAQEDDDDEVNIEDGKTLAILE----GHKAPVVSIDV-SDNSRILSASYDNSIGFWSTIY 238 Query: 277 GENTLVN--------YGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQIT 328 E T+V+ K+ ++K K T+ G T+ ++ Sbjct: 239 KEMTVVDPLEDINNPNNKISTAARKRRKLTMKDG-----------------TIRRRAPLS 281 Query: 329 MLKGHYKTVDCCVFQSNFQEL-YSGSRDCNILAW 361 +L+ H V+ +F S + YS S+D I W Sbjct: 282 LLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTW 315 >4V6W-Ag nrPDB Length = 318 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 68/299 (22%), Positives = 121/299 (40%), Gaps = 50/299 (16%) Query: 109 PHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVY--SHHMSPV--STKHCLVAVGTR 164 P D S+S DKTL VW + + ++ +Y SH +S V S+ G+ Sbjct: 25 PKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVLSSDGNYALSGSW 84 Query: 165 GPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLI 224 ++L DL +G + +GH +++L+V++S I++ S D +KLW+ I Sbjct: 85 DQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVS-GSRDKTIKLWNTLAECKFTI 143 Query: 225 TLDQHNGKKS-------------------QAVESANTA----------HNGKVNGLCFTS 255 D H S + V+ N A HNG +N + + Sbjct: 144 QEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNHHGHNGYLNTVTVSP 203 Query: 256 DGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGST 315 DG + G D++ LW+ ++G+N Y N+ L F+ + ++ V YG + Sbjct: 204 DGSLCTSGGKDSKALLWDLNDGKNL---YTLEHNDIINALCFSP----NRYWLCVAYGPS 256 Query: 316 IAVYTVYSGEQITML---------KGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSL 365 I ++ + + + L K + ++ Q L++G D I W S+ Sbjct: 257 IKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQVSV 315 Score = 35.4 bits (80), Expect = 0.047, Method: Compositional matrix adjust. Identities = 31/123 (25%), Positives = 53/123 (43%), Gaps = 6/123 (4%) Query: 243 AHNGKVNGLCFT-SDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSC 301 HNG V + D +++ D + +W + E+T NYG F Sbjct: 13 GHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDT--NYGYPQKRLYGHSHFISDV 70 Query: 302 GCSSEFVFVPYGS---TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNI 358 SS+ + GS T+ ++ + +G+ +GH K V F ++ +++ SGSRD I Sbjct: 71 VLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGSRDKTI 130 Query: 359 LAW 361 W Sbjct: 131 KLW 133 Score = 31.2 bits (69), Expect = 0.81, Method: Compositional matrix adjust. Identities = 36/165 (21%), Positives = 70/165 (42%), Gaps = 16/165 (9%) Query: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESAN 241 L GH + ++ +P+ + +AS D + +W + R D + G + + Sbjct: 11 LIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDE------DTNYGYPQKRLY--- 61 Query: 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSC 301 H+ ++ + +SDG + L+ D +RLW+ + G+ T G ++K L S Sbjct: 62 -GHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEG----HTKDVLSVAFSA 116 Query: 302 GCSSEFVFVPYGSTIAVYTVYSGEQITMLK-GHYKTVDCCVFQSN 345 + + V TI ++ + + T+ + GH V C F N Sbjct: 117 D-NRQIVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPN 160 >3FM0-A nrPDB Length = 345 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 60/225 (26%), Positives = 86/225 (38%), Gaps = 39/225 (17%) Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMF 115 G + S G D I ++ E S + CK+V S G H+ +V V W P Sbjct: 28 GTLLASCGGDRRIRIWGTEGDS----WICKSVLSEG------HQRTVRKVAWSPCGN-YL 76 Query: 116 TSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHC----LVAVGTRGPKVQLC 171 S+SFD T +W N D F T+ H S L+A +R V + Sbjct: 77 ASASFDATTCIWKKNQ----DDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVW 132 Query: 172 DLKSG---SCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASG-CLITLD 227 ++ C +L H Q++ V W P + +LA+AS D VKL+ C TL+ Sbjct: 133 EVDEEDEYECVSVLNSHTQDVKHVVWHPSQE-LLASASYDDTVKLYREEEDDWVCCATLE 191 Query: 228 QHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLW 272 H V L F G L + D +R+W Sbjct: 192 ---------------GHESTVWSLAFDPSGQRLASCSDDRTVRIW 221 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 15/43 (34%), Positives = 25/43 (58%) Query: 179 SHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASG 221 +H+ Q H Q++ V+W+P+ +LA+ S D V W +R G Sbjct: 296 AHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQRPEG 338 Score = 32.0 bits (71), Expect = 0.53, Method: Compositional matrix adjust. Identities = 28/139 (20%), Positives = 56/139 (40%), Gaps = 10/139 (7%) Query: 251 LCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFV 310 L + G L + G D R+R+W + ++ + + ++ ++ C + Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEG--DSWICKSVLSEGHQRTVRKVAWSPCGNYLASA 79 Query: 311 PYGSTIAVYTVYSG--EQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEP 368 + +T ++ E +T L+GH V + + L + SRD ++ W Sbjct: 80 SFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVW------E 133 Query: 369 VPDDDETTTKSQLNPAFED 387 V ++DE S LN +D Sbjct: 134 VDEEDEYECVSVLNSHTQD 152 >2HES-X nrPDB Length = 330 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 64/250 (25%), Positives = 105/250 (42%), Gaps = 34/250 (13%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTAD-VFNFE-ETVYSHHMSPV--- 152 H+ ++ +V W PH T + + SFD T+ +W ++AD F + + H + V Sbjct: 57 HKKAIRSVAWRPH-TSLLAAGSFDSTVSIWAKE--ESADRTFEMDLLAIIEGHENEVKGV 113 Query: 153 --STKHCLVAVGTRGPKVQLCDL-KSG---SCSHILQGHRQEILAVSWSPRYDYILATAS 206 S +A +R V + + +SG C +LQ H Q++ V W P + +LA++S Sbjct: 114 AWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPS-EALLASSS 172 Query: 207 ADSRVKLW-DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGT 265 D V++W D C+ L+ H G V S++ V LC SD Sbjct: 173 YDDTVRIWKDYDDDWECVAVLNGHEG----TVWSSDFDKTEGVFRLCSGSD--------- 219 Query: 266 DNRMRLWNSSNGENTLVNYGKVCN----NSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTV 321 D+ +R+W G++ VC + K + V+ G + V +AVY Sbjct: 220 DSTVRVWKYM-GDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNGLIASVGADGVLAVYEE 278 Query: 322 YSGEQITMLK 331 GE K Sbjct: 279 VDGEWKVFAK 288 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 52/236 (22%), Positives = 99/236 (41%), Gaps = 36/236 (15%) Query: 140 FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHI----LQGHRQEILAVSWS 195 ++E ++S S ++A G+ K++L +K + I H++ I +V+W Sbjct: 13 YKEKIWSFDFS-----QGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWR 67 Query: 196 PRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS 255 P + +LA S DS V +W ++ +D + + H +V G+ +++ Sbjct: 68 P-HTSLLAAGSFDSTVSIWAKEESADRTFEMD---------LLAIIEGHENEVKGVAWSN 117 Query: 256 DGLHLLTVGTDNRMRLW--NSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYG 313 DG +L T D + +W + S E ++ V + +K + + Y Sbjct: 118 DGYYLATCSRDKSVWIWETDESGEEYECIS---VLQEHSQDVKHVIWHPSEALLASSSYD 174 Query: 314 STIAVYTVYSG--EQITMLKGHYKTVDCCVFQSNFQE------LYSGSRDCNILAW 361 T+ ++ Y E + +L GH T V+ S+F + L SGS D + W Sbjct: 175 DTVRIWKDYDDDWECVAVLNGHEGT----VWSSDFDKTEGVFRLCSGSDDSTVRVW 226 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 26/90 (28%), Positives = 40/90 (44%), Gaps = 11/90 (12%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVL---YDLENSSRQSYYTCKAVCSIGRDHPDVH 98 H G + + D + EG + L GSD V Y ++ Q + C+A+ PDVH Sbjct: 196 HEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAIL------PDVH 249 Query: 99 RYSVETVQWYPHDTGMFTSSSFDKTLKVWD 128 + V V W + G+ S D L V++ Sbjct: 250 KRQVYNVAWGFN--GLIASVGADGVLAVYE 277 >5FVM-C nrPDB Length = 303 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 57/242 (23%), Positives = 91/242 (37%), Gaps = 37/242 (15%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H G + ++ + E R+M+S DG I ++D+ + S Q Y H Sbjct: 74 HKGNVTSIAFQQ-ENRWMVSSSEDGTIKVWDVRSPSVQRNYK--------------HNAP 118 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 V V +P + G S D +++WD Q + E+ +S S LVA Sbjct: 119 VNEVAIHP-NQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAG 177 Query: 162 GTRGP-----KVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 +G D + + H + I V S LAT SAD ++W++ Sbjct: 178 NNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKN-LATCSADHTARVWNI 236 Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN 276 TLD H V F++D +L+T +D+ +RLW+ S Sbjct: 237 EDNYQLETTLD---------------GHQRWVWDCAFSADSAYLVTACSDHYVRLWDLST 281 Query: 277 GE 278 E Sbjct: 282 SE 283 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 43/180 (23%), Positives = 78/180 (43%), Gaps = 41/180 (22%) Query: 114 MFTSSSFDKTLKVWD------TNTLQTAD--VFNFEETVYSHHMSPVSTKHCLVAVGTRG 165 + S+ +D T++ W+ + T+Q AD V E T S K L A G Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEIT---------SDKKYLAAAGHL- 53 Query: 166 PKVQLCDLKSGSCSHI--LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCL 223 V+L D++S + + + +GH+ + ++++ +++++ S D +K+WDVR S Sbjct: 54 -HVRLYDIRSNNPNPVSSFEGHKGNVTSIAFQQENRWMVSS-SEDGTIKVWDVRSPS--- 108 Query: 224 ITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVN 283 N HN VN + + L++ D +R+W+ GEN N Sbjct: 109 --------------VQRNYKHNAPVNEVAIHPNQGELISCDQDGNIRIWDL--GENQCTN 152 >5CXC-A nrPDB Length = 510 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 44/197 (22%), Positives = 83/197 (42%), Gaps = 22/197 (11%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTC-----------KAVCSI 90 H G ++ LD++ +++L+ +DG I + +S KA S+ Sbjct: 239 HTGSVDWLDVDG-HSKHILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSV 297 Query: 91 --GRDHP----DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETV 144 + P +H + P D + S+S D T++ D T Q + Sbjct: 298 STAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPL 357 Query: 145 YS-HHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCS---HILQGHRQEILAVSWSPRYDY 200 S ++ T L+A GT + + D ++ S + L+GH +++++S SP +Y Sbjct: 358 LSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEY 417 Query: 201 ILATASADSRVKLWDVR 217 L + S D ++WD+R Sbjct: 418 SLVSGSHDGTCRVWDLR 434 >6HHQ-h nrPDB Length = 319 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 42/163 (25%), Positives = 69/163 (42%), Gaps = 26/163 (15%) Query: 117 SSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMS-PVSTKHCLVAVGTRGPKVQLCDLKS 175 S+S+DKTL++WD T +T F + S MS + K ++ G+R +++ +K Sbjct: 82 SASWDKTLRLWDVATGETYQRFVGHK---SDVMSVDIDKKASMIISGSRDKTIKVWTIK- 137 Query: 176 GSCSHILQGHRQEILAVSWSPRY-----DYILATASADSRVKLWDVRRASGCLITLDQHN 230 G C L GH + V P + +A D VK W++ + Sbjct: 138 GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQ---------- 187 Query: 231 GKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 +E+ HN +N L + DG + + G D + LWN Sbjct: 188 ------IEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWN 224 Score = 35.4 bits (80), Expect = 0.049, Method: Compositional matrix adjust. Identities = 40/163 (24%), Positives = 73/163 (44%), Gaps = 15/163 (9%) Query: 111 DTGMFTSSSFDKTLKVWDTNTLQT-ADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQ 169 D+ S+ DK +K W+ N Q AD + + SP T L+A + ++ Sbjct: 165 DSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGT---LIASAGKDGEIM 221 Query: 170 LCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQH 229 L +L + + L + E+ ++++SP Y LA A+A + +K++ + + L Sbjct: 222 LWNLAAKKAMYTLSA-QDEVFSLAFSPNR-YWLAAATA-TGIKVFSLD-PQYLVDDLRPE 277 Query: 230 NGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLW 272 S+A E + L +++DG L TDN +R+W Sbjct: 278 FAGYSKAAEPHAVS-------LAWSADGQTLFAGYTDNVIRVW 313 Score = 30.8 bits (68), Expect = 0.94, Method: Compositional matrix adjust. Identities = 37/155 (23%), Positives = 64/155 (41%), Gaps = 23/155 (14%) Query: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESAN 241 L+GH + +++ S +L +AS D + W L DQ G ++ + Sbjct: 13 LEGHNGWVTSLATSAGQPNLLLSASRDKTLISWK-------LTGDDQKFGVPVRSFK--- 62 Query: 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSC 301 H+ V T+DG + L+ D +RLW+ + GE Y + + + + Sbjct: 63 -GHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGE----TYQRFVGHKSDVMSVDIDK 117 Query: 302 GCSSEFVFVPYGS---TIAVYTVYSGEQITMLKGH 333 S + GS TI V+T+ G+ + L GH Sbjct: 118 KAS----MIISGSRDKTIKVWTI-KGQCLATLLGH 147 >3JB9-L nrPDB Length = 340 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 30/104 (28%), Positives = 57/104 (54%), Gaps = 4/104 (3%) Query: 114 MFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDL 173 + TS S D T+KVWD+ ++ D E Y ++ + V +G +++ DL Sbjct: 150 LLTSVSDDCTMKVWDS---RSKDCIKTIEEKYPLTAVAIAQQGTQVFIGGIDGAIKIWDL 206 Query: 174 KSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 ++ CSH+L+GH+ I +++ S +L+ S D+ V+++DV+ Sbjct: 207 RNNHCSHVLKGHKDIITSLAISKDGSSLLSN-SMDNTVRIFDVK 249 Score = 35.4 bits (80), Expect = 0.043, Method: Compositional matrix adjust. Identities = 39/158 (24%), Positives = 66/158 (41%), Gaps = 21/158 (13%) Query: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGM 114 +G + GG DG I ++DL N+ C V + H D + T D Sbjct: 188 QGTQVFIGGIDGAIKIWDLRNNH------CSHVL---KGHKD-----IITSLAISKDGSS 233 Query: 115 FTSSSFDKTLKVWDTNTLQTA--DVFNFEETVY--SHHMSPV--STKHCLVAVGTRGPKV 168 S+S D T++++D +A + FE ++ H++ V S V G+ V Sbjct: 234 LLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNV 293 Query: 169 QLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATAS 206 + +G ++L GH + V + P D IL+ +S Sbjct: 294 YVWS-ATGDLRYVLPGHEGSVNHVDFHPHQDIILSCSS 330 Score = 31.2 bits (69), Expect = 0.86, Method: Compositional matrix adjust. Identities = 32/121 (26%), Positives = 49/121 (40%), Gaps = 7/121 (5%) Query: 243 AHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCG 302 H +V F G + + G D ++ LWN + NYG + N KG + Sbjct: 48 GHTAEVLVARFDPSGSYFASGGMDRQILLWNVF---GDVKNYGVL--NGCKGAITDLQWS 102 Query: 303 CSSEFVFVPYGST-IAVYTVYSGEQITMLKGHYKTVDCC-VFQSNFQELYSGSRDCNILA 360 S V+ T + + SG++I KGH V+ V + + L S S DC + Sbjct: 103 RDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKV 162 Query: 361 W 361 W Sbjct: 163 W 163 >2PM9-A nrPDB Length = 416 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 59/233 (25%), Positives = 97/233 (41%), Gaps = 39/233 (16%) Query: 68 IVLYDLENSSRQSYYTCKA---VCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTL 124 I+ L+N S + Y T +A + S+ R H SV+TV++ + S + + Sbjct: 81 IIAGALDNGSLELYSTNEANNAINSMARF--SNHSSSVKTVKFNAKQDNVLASGGNNGEI 138 Query: 125 KVWDTNTLQTADVFNFEETVYSHHMSPV----------STKHCLVAVGTRGPKVQLCDLK 174 +WD N T N+ MS V S H + G+ + DLK Sbjct: 139 FIWDMNKC-TESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSN-FASIWDLK 196 Query: 175 SG------SCSHILQGHRQEILAVSWSPRYDYILATASA---DSRVKLWDVRRASGCLIT 225 + S + G +Q++ V W P+ +ATA+ D + +WD+R A+ L T Sbjct: 197 AKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQT 256 Query: 226 LDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 L+Q + K +++ C + L LL+ G DN + LWN + E Sbjct: 257 LNQGHQKGILSLD------------WCHQDEHL-LLSSGRDNTVLLWNPESAE 296 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 38/189 (20%), Positives = 81/189 (42%), Gaps = 16/189 (8%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN-SSRQSYYTCKAVCSIGRDHPDVHRY 100 H + T+ + + SGG++G I ++D+ + S YT + G+ V Sbjct: 112 HSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTP---LTPGQSMSSVDE- 167 Query: 101 SVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ-------TADVFNFEETVYSHHMSPVS 153 V ++ W +F S+ +WD + T+ ++ + P + Sbjct: 168 -VISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKN 226 Query: 154 TKHCLVAVGT-RGPKVQLCDLKSGSC--SHILQGHRQEILAVSWSPRYDYILATASADSR 210 + A G+ P + + DL++ + + QGH++ IL++ W + +++L ++ D+ Sbjct: 227 STRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNT 286 Query: 211 VKLWDVRRA 219 V LW+ A Sbjct: 287 VLLWNPESA 295 >4BTS-AR nrPDB Length = 343 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 43/179 (24%), Positives = 82/179 (45%), Gaps = 26/179 (14%) Query: 110 HDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEE---TVYSHHMS--PVSTKHCLVAVGTR 164 D+ + S S DKT+ +W + F T ++H +S +S ++C + Sbjct: 37 EDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSSW 96 Query: 165 GPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLI 224 ++L DL++G+ GH+ E+ +V++SP IL +A A+ +KLW++ C Sbjct: 97 DKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQIL-SAGAEREIKLWNI--LGECKF 153 Query: 225 TLDQHNG--------KKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 + + + S ++SAN KV + +VG D R+++WN++ Sbjct: 154 SSAEKENHSDWVSCVRYSPIMKSAN-----KVQPFA-----PYFASVGWDGRLKVWNTN 202 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 12/36 (33%), Positives = 22/36 (61%), Gaps = 1/36 (2%) Query: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 + H +N L I P G+Y+ +GG D ++++D+ N Sbjct: 210 KAHESNVNHLSISP-NGKYIATGGKDKKLLIWDILN 244 >3JB9-g nrPDB Length = 558 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 47/210 (22%), Positives = 83/210 (39%), Gaps = 31/210 (14%) Query: 166 PKVQLCDLKSGSCSHIL--QGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCL 223 P Q C + HI +GH + I + + P ++L + S D+++K+W+V L Sbjct: 247 PGEQTCYIPK---KHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLL 303 Query: 224 ITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVN 283 T H + L F+ DG L+ D ++LW++ G+ +N Sbjct: 304 RTF---------------QGHARPIRDLSFSQDGRSFLSTSFDKTIKLWDTELGK--CLN 346 Query: 284 YGKVCNNSKK---GLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCC 340 C NS + +KF V +EF+ I + + S + + H ++ Sbjct: 347 ----CFNSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDIRSPDIVQAYDHHLGGINSI 402 Query: 341 VFQSNFQELYSGSRDCNILAWVPSLYEPVP 370 F N + + S D ++ W PVP Sbjct: 403 TFLENGKRFVTTSDDSSMRFW--EYGTPVP 430 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 53/231 (22%), Positives = 82/231 (35%), Gaps = 72/231 (31%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H GI+ L P+ G +LSG D I ++++ + R T + RD Sbjct: 265 HTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHD-RSLLRTFQGHARPIRDLS------ 317 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 + D F S+SFDKT+K+WDT + + FN + +C+ Sbjct: 318 ------FSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLT-----------NCV--- 357 Query: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASG 221 K Q+ K E LA +AD R+ +D+R Sbjct: 358 -----KFQVDPDKPN-----------EFLA-------------GTADKRILQFDIR---- 384 Query: 222 CLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLW 272 S + A H G +N + F +G +T D+ MR W Sbjct: 385 ------------SPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFW 423 >4AEZ-A nrPDB Length = 401 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 53/250 (21%), Positives = 111/250 (44%), Gaps = 34/250 (13%) Query: 119 SFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKH--CLVAVGTRGPKVQLCDLKSG 176 + ++ + VW+ ++ V ET S +++ V H ++VG V + D++S Sbjct: 110 ALERNVYVWNADS---GSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVESQ 166 Query: 177 SCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQA 236 + + GH+ + +SW+ ++L++ S + DVR A+ + TL Sbjct: 167 TKLRTMAGHQARVGCLSWN---RHVLSSGSRSGAIHHHDVRIANHQIGTLQ--------- 214 Query: 237 VESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLK 296 H+ +V GL + SDGL L + G DN +++W++ +++ + K +N+ +K Sbjct: 215 ------GHSSEVCGLAWRSDGLQLASGGNDNVVQIWDA---RSSIPKFTKTNHNA--AVK 263 Query: 297 FTVSCGCSSEFVFVPYGST---IAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYS-- 351 C S + G+ I + +G ++ + + V ++ + +E+ S Sbjct: 264 AVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQ-VTSLIWSPHSKEIMSTH 322 Query: 352 GSRDCNILAW 361 G D N+ W Sbjct: 323 GFPDNNLSIW 332 Score = 30.8 bits (68), Expect = 1.0, Method: Compositional matrix adjust. Identities = 48/269 (17%), Positives = 92/269 (34%), Gaps = 74/269 (27%) Query: 55 EGRYMLSGGSDGVIVLYDLENSSR-------QSYYTC----KAVCSIGRDHPDVHRYSVE 103 +G ++ G +G++ +YD+E+ ++ Q+ C + V S G +H + V Sbjct: 145 DGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWNRHVLSSGSRSGAIHHHDVR 204 Query: 104 TVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGT 163 H G S + W ++ LQ +A G Sbjct: 205 IAN---HQIGTLQGHSSEVCGLAWRSDGLQ-------------------------LASGG 236 Query: 164 RGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATA--SADSRVKLWDVRRASG 221 VQ+ D +S H + AV+W P +LAT + D ++ W+ A+G Sbjct: 237 NDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNA--ATG 294 Query: 222 CLITLDQHNGKKSQAVESANT-------------------------------AHNGKVNG 250 + + + + S ++ AH+ +V Sbjct: 295 ARVNTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLY 354 Query: 251 LCFTSDGLHLLTVGTDNRMRLWNSSNGEN 279 + DG L T +D ++ W +G++ Sbjct: 355 SALSPDGRILSTAASDENLKFWRVYDGDH 383 >6J6H-n nrPDB Length = 455 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 45/177 (25%), Positives = 75/177 (42%), Gaps = 19/177 (10%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H G L P G +LSGG+D I ++D + Y C RD H Sbjct: 161 HPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD-----YECL------RDF-QGHNKP 208 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 ++ ++ + D F SSSFD+++K+WDT T + + T P + + V Sbjct: 209 IKALR-FTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFI--V 265 Query: 162 GTRGPKVQLCDLKSGSCSHILQG---HRQEILAVSWSPRYDYILATASADSRVKLWD 215 G K+ D + ++Q H ILA+ + P ++ +S D V++W+ Sbjct: 266 GLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFIS-SSEDKTVRIWE 321 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 20/95 (21%), Positives = 38/95 (40%), Gaps = 15/95 (15%) Query: 184 GHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTA 243 GH + A+ + P+ +++ + D +K+WD CL Sbjct: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDF---------------QG 204 Query: 244 HNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 HN + L FT D L+ D +++W++ G+ Sbjct: 205 HNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGK 239 >5WYJ-BC nrPDB Length = 817 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 58/258 (22%), Positives = 109/258 (42%), Gaps = 43/258 (16%) Query: 35 DRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDL-ENSSRQSYYT-----CKAVC 88 D ++ H +N+LD +G ++ + D +++ ENS + Y AV Sbjct: 380 DVEIYEGHEDLLNSLDATE-DGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVT 438 Query: 89 SIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVW----DTNTLQTADVFNFEETV 144 ++G P++ + YP ++S D T+K W T ++ + E T Sbjct: 439 AVGL--PNI------VSKGYPE---FLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTR 487 Query: 145 YSHHMS----PVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDY 200 ++H VS + A + ++ +L++G L H++ + VS+ +YD Sbjct: 488 HAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFC-QYDK 546 Query: 201 ILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHL 260 +LAT+S D VK+W +LD + K+ H V F + L Sbjct: 547 LLATSSGDKTVKIW----------SLDTFSVMKTLE------GHTNAVQRCSFINKQKQL 590 Query: 261 LTVGTDNRMRLWNSSNGE 278 ++ G D +++W+ S+GE Sbjct: 591 ISCGADGLIKIWDCSSGE 608 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 47/184 (25%), Positives = 72/184 (39%), Gaps = 19/184 (10%) Query: 184 GHRQEILAVSW----SPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVES 239 GH + AV S Y L TAS D +K W + + + ++D K S E Sbjct: 432 GHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTA---SMDVQIIKVS---EY 485 Query: 240 ANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE--NTLVNYGKVCNNSKKGLKF 297 AH +N L + + T D ++WN NGE TL N+ K+GL Sbjct: 486 TRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANH-------KRGLWD 538 Query: 298 TVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCN 357 C T+ ++++ + + L+GH V C F + ++L S D Sbjct: 539 VSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGL 598 Query: 358 ILAW 361 I W Sbjct: 599 IKIW 602 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 55/238 (23%), Positives = 98/238 (41%), Gaps = 37/238 (15%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H IN L + P + + + D +++LEN ++ H+ Sbjct: 490 HEKDINALSVSPNDSIFA-TASYDKTCKIWNLENGELEATLAN-------------HKRG 535 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSH-----HMSPVSTKH 156 + V + +D + +SS DKT+K+W + D F+ +T+ H S ++ + Sbjct: 536 LWDVSFCQYDK-LLATSSGDKTVKIW------SLDTFSVMKTLEGHTNAVQRCSFINKQK 588 Query: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 L++ G G +++ D SG C L GH + A+S D I+ +A AD + W Sbjct: 589 QLISCGADG-LIKIWDCSSGECLKTLDGHNNRLWALSTMNDGDMIV-SADADGVFQFW-- 644 Query: 217 RRASGCLITLDQHNGKKSQ-AVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 C + +K++ VE + N G + LL + D+ MRL+N Sbjct: 645 ---KDCTEQEIEEEQEKAKLQVEQEQSLQNYMSKGDWTNA---FLLAMTLDHPMRLFN 696 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 29/119 (24%), Positives = 59/119 (49%), Gaps = 13/119 (10%) Query: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYD---YILATASADSRVKLW 214 L+AVG + + D+++G +H +GH I ++ + + + ++LA+ + VK+W Sbjct: 116 LLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVW 175 Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 D+ + CL TL +H + ++ N + L+LL+ G D+ + LW+ Sbjct: 176 DLVKRK-CLHTLQEHTS-AVRGLDIIEVPDNDE--------PSLNLLSGGRDDIINLWD 224 >6G51-g nrPDB Length = 317 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 63/254 (24%), Positives = 109/254 (42%), Gaps = 43/254 (16%) Query: 55 EGRYMLSGGSDGVIVLYDLEN--SSRQSYYTCKAVCSIG------------RD------- 93 +G++ LSG DG + L+DL ++R+ K V S+ RD Sbjct: 74 DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133 Query: 94 ---------HPDVHRYSVETVQWYPHDTG-MFTSSSFDKTLKVWDTNTLQTADVFNFEET 143 + H V V++ P+ + + S +DK +KVW+ + + T Sbjct: 134 TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK-LKTNHIGHT 192 Query: 144 VYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILA 203 Y + ++ VS L A G + + L DL G + L G I A+ +SP Y L Sbjct: 193 GYLNTVT-VSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DIINALCFSPNR-YWLC 249 Query: 204 TASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTV 263 A+ S +K+WD+ I +D+ K + + +++ A + L +++DG L Sbjct: 250 AATGPS-IKIWDLEGK----IIVDE---LKQEVISTSSKAEPPQCTSLAWSADGQTLFAG 301 Query: 264 GTDNRMRLWNSSNG 277 TDN +R+W + G Sbjct: 302 YTDNLVRVWQVTIG 315 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 54/248 (21%), Positives = 100/248 (40%), Gaps = 33/248 (13%) Query: 36 RDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP 95 R + H G + + P +LS D I+++ L +A+ R H Sbjct: 8 RGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRAL----RGHS 63 Query: 96 DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF-NFEETVYSHHMSPVST 154 H S + D S S+D TL++WD T T F + V S S+ Sbjct: 64 --HFVSDVVIS---SDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLS---VAFSS 115 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQ--GHRQEILAVSWSPRY-DYILATASADSRV 211 + + G+R ++L + G C + +Q H + + V +SP + I+ + D V Sbjct: 116 DNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 Query: 212 KLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL 271 K+W++ + C +++ + H G +N + + DG + G D + L Sbjct: 175 KVWNL---ANC-------------KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML 218 Query: 272 WNSSNGEN 279 W+ + G++ Sbjct: 219 WDLNEGKH 226 Score = 37.4 bits (85), Expect = 0.012, Method: Compositional matrix adjust. Identities = 40/181 (22%), Positives = 68/181 (37%), Gaps = 60/181 (33%) Query: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHN-GKKSQAVESA 240 L+GH + ++ +P++ ++ +AS D + +W + R D+ N G +A+ Sbjct: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR--------DETNYGIPQRALR-- 60 Query: 241 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS 300 H+ V+ + +SDG L+ D +RLW+ + G T Sbjct: 61 --GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTT-------------------- 98 Query: 301 CGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA 360 FV GH K V F S+ +++ SGSRD I Sbjct: 99 ----RRFV-----------------------GHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131 Query: 361 W 361 W Sbjct: 132 W 132 >5WBU-D nrPDB Length = 328 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 54/235 (22%), Positives = 98/235 (41%), Gaps = 38/235 (16%) Query: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGM 114 +GR+M +GG D ++DL + + Q C+ + + + V +P+ + Sbjct: 98 DGRWMYTGGEDCTARIWDLRSRNLQ----CQRIFQVNA--------PINCVCLHPNQAEL 145 Query: 115 FTSSSFDKTLKVWDTNTLQTADVFNFEE-TVYSHHMSPVSTKHCLVAVGTRGPKVQLCDL 173 + +WD T + E ++ S H+ P ++ + AV + G + +L Sbjct: 146 IVGDQ-SGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY--MAAVNSTG-NCYVWNL 201 Query: 174 KSGSCSHILQ--------GHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLIT 225 G + Q H + L +SP +LAT SAD K+W R ++ L+T Sbjct: 202 TGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD-STLLATCSADQTCKIW--RTSNFSLMT 258 Query: 226 LDQHNGKKSQAVESANTAHN--GKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 +++S N + G + G F+ D +++T +DN RLW GE Sbjct: 259 --------ELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGE 305 >5M89-A nrPDB Length = 329 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 42/176 (23%), Positives = 73/176 (41%), Gaps = 19/176 (10%) Query: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 + H G + L + P GR + S G D V YDLE R + R + D Sbjct: 127 QTHAGPVTGLAVHP-GGRILASVGVDKSFVFYDLETGER-----------VARGYADA-- 172 Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLV 159 ++ T ++P D +F + + + V+ T TL+ A+ F + + S Sbjct: 173 -ALTTCAFHP-DGNLFAAGTQTGHILVFHTTTLEQAESFPLGTPIQALAFS--ENGFWFA 228 Query: 160 AVGTRGPKVQLCDL-KSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLW 214 A G V + DL KSG+ + + + E+L++SW Y+ V+++ Sbjct: 229 ATGKGTSSVTIFDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATGGGTGVTVQMY 284 >5WYK-BB nrPDB Length = 943 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 49/248 (19%), Positives = 103/248 (41%), Gaps = 32/248 (12%) Query: 38 VERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDV 97 +E H I +LD+ +G+ +++G +D + +D + + T + + H D Sbjct: 468 IEDAHDAAIWSLDLTS-DGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDT 526 Query: 98 HRY---SVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMS---- 150 + V+ P D S D T+KV+ ++++ F ++Y H + Sbjct: 527 TLELTDDILCVRVSPDDR-YLAISLLDNTVKVFFLDSMK------FYLSLYGHKLPVLSI 579 Query: 151 PVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSR 210 +S ++ + +++ L G C L H+ I+ V + P+ + + S D+ Sbjct: 580 DISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQ-SHNFFSCSKDAV 638 Query: 211 VKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMR 270 VK WD G+K + ++ AH +V L +DG +++ D+ +R Sbjct: 639 VKYWD---------------GEKFECIQKL-YAHQSEVWALAVATDGGFVVSSSHDHSIR 682 Query: 271 LWNSSNGE 278 +W + + Sbjct: 683 IWEETEDQ 690 Score = 44.7 bits (104), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 54/226 (23%), Positives = 92/226 (40%), Gaps = 32/226 (14%) Query: 111 DTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQL 170 DT + D +KVWD + + NF + + + G++ + + Sbjct: 90 DTDLLAVGYADGVIKVWDL--MSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIV 147 Query: 171 CDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHN 230 DL + L+ H+ I W D++++T S D +KLWD+ Sbjct: 148 WDLVGEVGLYKLRSHKDSITGF-WCQGEDWLIST-SKDGMIKLWDL-------------- 191 Query: 231 GKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLW-----NSSNGENTLVNYG 285 K Q +E+ + AH G+ GL D L+T GTD+++++W N G L G Sbjct: 192 -KTHQCIET-HIAHTGECWGLAVKDD--LLITTGTDSQVKIWKLDIENDKMG-GKLTEMG 246 Query: 286 KVCNNSK-KGLK--FTVSCGCSSEFVFVPYG-STIAVYTVYSGEQI 327 SK +GLK F + + F ++ TI + + E+I Sbjct: 247 IFEKQSKQRGLKIEFITNSSDKTSFFYIQNADKTIETFRIRKEEEI 292 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 34/126 (26%), Positives = 57/126 (45%), Gaps = 28/126 (22%) Query: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRR------------------ASGCL 223 LQG R ++ ++ S + +LATAS S +K+W+++ G L Sbjct: 387 LQGQRTDVRSIDISDD-NKLLATASNGS-LKIWNIKTHKCIRTFECGYALTCKFLPGGLL 444 Query: 224 ITLDQHNGK-------KSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN 276 + L NG+ S +++ AH+ + L TSDG L+T D ++ W+ Sbjct: 445 VILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWD-FK 503 Query: 277 GENTLV 282 EN+LV Sbjct: 504 VENSLV 509 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 14/47 (29%), Positives = 20/47 (42%) Query: 315 TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 I V+ + S + GH + F L SGS+D NI+ W Sbjct: 102 VIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVW 148 >6EMK-B nrPDB Length = 303 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 54/242 (22%), Positives = 89/242 (36%), Gaps = 37/242 (15%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H G + ++ + + R+M++ DG I ++D+ + S Y H Sbjct: 74 HRGNVTSVSFQQ-DNRWMVTSSEDGTIKVWDVRSPSIPRNYK--------------HNAP 118 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 V V +P + G S D +++WD Q E+ +S S L A Sbjct: 119 VNEVVIHP-NQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 Query: 162 GTRGPKVQLCDLKSGSCSHI-----LQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 T+G SH+ + H I + S + LAT SAD ++W + Sbjct: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH-LATCSADHTARVWSI 236 Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN 276 TLD H V F++D +L+T +D+ +RLW+ S Sbjct: 237 DDDFKLETTLD---------------GHQRWVWDCAFSADSAYLVTASSDHYVRLWDLST 281 Query: 277 GE 278 E Sbjct: 282 RE 283 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 59/288 (20%), Positives = 113/288 (39%), Gaps = 38/288 (13%) Query: 114 MFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDL 173 + S+ +D T++ W+ T + ++ + + + K L G + V+L D+ Sbjct: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNR-LEITNDKKLLATAGHQN--VRLYDI 60 Query: 174 KSGSCSHI--LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRAS----------- 220 ++ + + + +GHR + +VS+ +++ T+S D +K+WDVR S Sbjct: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVRSPSIPRNYKHNAPV 119 Query: 221 ---------GCLITLDQHNGKK------SQAVESANTAHNGKVNGLCFTSDGLHLLTVGT 265 G LI+ D+ + +Q + + L SDG L T Sbjct: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 Query: 266 DNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGS---TIAVYTVY 322 +W N +T ++ K + + SS+ + S T V+++ Sbjct: 180 KGNCYVWEMPN--HTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID 237 Query: 323 SGEQI-TMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPV 369 ++ T L GH + V C F ++ L + S D + W S E V Sbjct: 238 DDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIV 285 Score = 35.4 bits (80), Expect = 0.038, Method: Compositional matrix adjust. Identities = 49/251 (19%), Positives = 93/251 (37%), Gaps = 30/251 (11%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHC 157 HR +V +V + D +SS D T+KVWD + + V + P + Sbjct: 74 HRGNVTSVS-FQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGE-- 130 Query: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 L++ G +++ DL C+H L L +LA A+ +W+ Sbjct: 131 LISCDRDG-NIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE-- 187 Query: 218 RASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNG 277 + H + AH+ + + +SD HL T D+ R+W+ + Sbjct: 188 --------MPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD 239 Query: 278 ---ENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGST---IAVYTVYSGEQITMLK 331 E TL + ++ C S++ ++ S+ + ++ + + E + Sbjct: 240 FKLETTLDGHQ----------RWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYG 289 Query: 332 GHYKTVDCCVF 342 GH+K C Sbjct: 290 GHHKGAVCVAL 300 >6Q8F-A nrPDB Length = 514 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 41/182 (22%), Positives = 76/182 (41%), Gaps = 13/182 (7%) Query: 180 HILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVES 239 HI G + + +SP Y L T S D +++W+ T K QA ++ Sbjct: 209 HIKFGQKSHVECARFSPDGQY-LVTGSVDGFIEVWN-------FTTGKIRKDLKYQAQDN 260 Query: 240 ANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTV 299 + V +CF+ D L T D ++++W +G+ L + + + L F+ Sbjct: 261 FMMMDDA-VLCMCFSRDTEMLATGAQDGKIKVWKIQSGQ-CLRRFERAHSKGVTCLSFSK 318 Query: 300 SCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNIL 359 SS+ + + TI ++ + SG+ + +GH V+ F + + S S D + Sbjct: 319 D---SSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVK 375 Query: 360 AW 361 W Sbjct: 376 IW 377 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 43/201 (21%), Positives = 83/201 (41%), Gaps = 34/201 (16%) Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHC---- 157 VE ++ P D + S D ++VW+ T + ++ M C Sbjct: 218 VECARFSP-DGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRD 276 Query: 158 --LVAVGTRGPKVQLCDLKSGSC-SHILQGHRQEILAVSWSPRYDYILATASADSRVKLW 214 ++A G + K+++ ++SG C + H + + +S+S IL +AS D +++ Sbjct: 277 TEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQIL-SASFDQTIRIH 335 Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 ++ TL + G H+ VN FT DG ++++ +D +++WN Sbjct: 336 GLKSGK----TLKEFRG------------HSSFVNEATFTQDGHYIISASSDGTVKIWNM 379 Query: 275 SNGENTLVNYGKVCNNSKKGL 295 E C+N+ K L Sbjct: 380 KTTE---------CSNTFKSL 391 Score = 34.3 bits (77), Expect = 0.10, Method: Compositional matrix adjust. Identities = 36/167 (21%), Positives = 72/167 (43%), Gaps = 16/167 (9%) Query: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETV--QWYPHDT 112 +G+Y+++G DG I +++ + T K + D + V + DT Sbjct: 226 DGQYLVTGSVDGFIEVWN--------FTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDT 277 Query: 113 GMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMS--PVSTKHCLVAVGTRGPKVQL 170 M + + D +KVW + Q F E +S ++ S + + +++ Sbjct: 278 EMLATGAQDGKIKVWKIQSGQCLRRF---ERAHSKGVTCLSFSKDSSQILSASFDQTIRI 334 Query: 171 CDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 LKSG +GH + +++ YI+ +AS+D VK+W+++ Sbjct: 335 HGLKSGKTLKEFRGHSSFVNEATFTQDGHYII-SASSDGTVKIWNMK 380 >4V7E-Bg nrPDB Length = 380 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 60/278 (21%), Positives = 102/278 (36%), Gaps = 60/278 (21%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHC 157 H+ + Q+ P + S D+T +WD T Q +F Sbjct: 156 HKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIF------------------- 196 Query: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 G+ P GH ++L++S + + + S D+ V+LWD+R Sbjct: 197 ----GSEFPS----------------GHTADVLSLSINSLNANMFISGSCDTTVRLWDLR 236 Query: 218 RASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNG 277 IT S+AV + + H G +N + F DG T D RL++ G Sbjct: 237 ------IT--------SRAVRTYH-GHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTG 281 Query: 278 ENTLV-NYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGS-TIAVYTVYSGEQI----TMLK 331 V N N+++ + +V+ S +F Y + V+ E + T+ Sbjct: 282 HQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQN 341 Query: 332 GHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPV 369 H + C S+ L +GS D N+ W S + + Sbjct: 342 SHEGRISCLGLSSDGSALCTGSWDKNLKIWAFSGHRKI 379 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 59/270 (21%), Positives = 104/270 (38%), Gaps = 46/270 (17%) Query: 22 ESTRRVLGLELNKDRD----VERI---HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLE 74 +S + L DRD V R+ H G ++ P + +++G D VL+D+ Sbjct: 129 DSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVT 188 Query: 75 NSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQT 134 R S + G + P H V ++ + MF S S D T+++WD Sbjct: 189 TGQRISIF--------GSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSR 240 Query: 135 A--DVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQE---- 188 A E + S P + G+ +L D+++G H LQ + +E Sbjct: 241 AVRTYHGHEGDINSVKFFPDGQR---FGTGSDDGTCRLFDMRTG---HQLQVYNREPDRN 294 Query: 189 ------ILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANT 242 + +V++S + A S + +WD A L + + Sbjct: 295 DNELPIVTSVAFSISGRLLFAGYS-NGDCYVWDTLLAEMVL------------NLGTLQN 341 Query: 243 AHNGKVNGLCFTSDGLHLLTVGTDNRMRLW 272 +H G+++ L +SDG L T D +++W Sbjct: 342 SHEGRISCLGLSSDGSALCTGSWDKNLKIW 371 Score = 34.3 bits (77), Expect = 0.086, Method: Compositional matrix adjust. Identities = 13/39 (33%), Positives = 25/39 (64%), Gaps = 1/39 (2%) Query: 178 CSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 C LQGH ++ ++ W+P ++I+ +AS D R+ +W+ Sbjct: 58 CCRTLQGHSGKVYSLDWTPEKNWIV-SASQDGRLIVWNA 95 >3JAP-g nrPDB Length = 326 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 68/338 (20%), Positives = 129/338 (38%), Gaps = 52/338 (15%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H G + +L + ++SG D ++ + L + +Q ++ H + Sbjct: 17 HNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKG--------HSHI 68 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF-NFEETVYSHHMSPVSTKHCLVA 160 V+ V D S+S+DKTL++W+ T + F V S + S+K + Sbjct: 69 VQDVV-VSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSK---II 124 Query: 161 VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRY---------DYILATASADSRV 211 +R +++ + G C+++L GH + V +P+ +A D V Sbjct: 125 SASRDKTIRVWN-TVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIV 183 Query: 212 KLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL 271 + W + + S +E+ HN +N + + DG + G D ++ + Sbjct: 184 RSWSLN--------------EDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYV 229 Query: 272 WNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLK 331 WN L + N K F ++ S ++ S I +Y + + I LK Sbjct: 230 WN-------LKHKSAFMNFDAKDEVFALAFSPSRFWLTAATASGIKIYDLENEVLIDELK 282 Query: 332 ----GHYKTVD----CCVFQSNFQELYSGSRDCNILAW 361 G+ K D + ++ Q L++G D I W Sbjct: 283 PEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVW 320 >5NZU-C nrPDB Length = 905 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 66/351 (18%), Positives = 125/351 (35%), Gaps = 100/351 (28%) Query: 46 INTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETV 105 + ++D+ P E +ML+ +G + ++ N Q+ VC + V Sbjct: 18 VKSVDLHPTEP-WMLASLYNGSVCVW---NHETQTLVKTFEVCDL----------PVRAA 63 Query: 106 QWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF----NFEETVYSHHMSPVSTKHCLVAV 161 ++ + T + D ++V++ NTL+ +F ++ + H P + Sbjct: 64 KFVARKNWVVTGAD-DMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQP------FILT 116 Query: 162 GTRGPKVQLCDL-KSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRAS 220 + ++L D K SCS + +GH ++ + +P+ + A+AS D +K+W + +S Sbjct: 117 SSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSS 176 Query: 221 GCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS--DGLHLLTVGTDNRMRLWNSSNGE 278 TL+ H VN + + S D +L++ D +++W+ N Sbjct: 177 PNF-TLE---------------GHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQN-- 218 Query: 279 NTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVD 338 K C + L+GH + V Sbjct: 219 -------KTC--------------------------------------VQTLEGHAQNVS 233 Query: 339 CCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAW 389 C F + +GS D + W S Y +S LN E W Sbjct: 234 CASFHPELPIIITGSEDGTVRIWHSSTYR---------LESTLNYGMERVW 275 >3MKQ-A nrPDB Length = 814 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 42/180 (23%), Positives = 76/180 (42%), Gaps = 25/180 (13%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN--SSRQSYYTCKAVCSIGRDHPDVHR 99 H I ++ + P + Y+LSG D + L++ EN + Q++ + H Sbjct: 96 HPDYIRSIAVHPTK-PYVLSGSDDLTVKLWNWENNWALEQTF--------------EGHE 140 Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNF----EETVYSHHMSPVSTK 155 + V V + P D F S D+T+KVW Q+ F E V P+ K Sbjct: 141 HFVMCVAFNPKDPSTFASGCLDRTVKVWSLG--QSTPNFTLTTGQERGVNYVDYYPLPDK 198 Query: 156 HCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 ++ + +++ D ++ SC L+GH + + P I+ + S D +K+W+ Sbjct: 199 PYMIT-ASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLP-IIISGSEDGTLKIWN 256 Score = 36.2 bits (82), Expect = 0.028, Method: Compositional matrix adjust. Identities = 49/241 (20%), Positives = 83/241 (34%), Gaps = 46/241 (19%) Query: 159 VAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRR 218 + VG+ ++++ + +G + H I +++ P Y+L + S D VKLW Sbjct: 70 IIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVL-SGSDDLTVKLW---- 124 Query: 219 ASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVG-TDNRMRLWNS--- 274 N + + A+E H V + F G D +++W+ Sbjct: 125 -----------NWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQS 173 Query: 275 ------SNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQIT 328 + G+ VNY K T S TI ++ + + Sbjct: 174 TPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDL-----------TIKIWDYQTKSCVA 222 Query: 329 MLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDA 388 L+GH V VF + SGS D + W S Y+ + LN E + Sbjct: 223 TLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYK---------VEKTLNVGLERS 273 Query: 389 W 389 W Sbjct: 274 W 274 >2YNP-A nrPDB Length = 604 Score = 44.7 bits (104), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 42/180 (23%), Positives = 76/180 (42%), Gaps = 25/180 (13%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN--SSRQSYYTCKAVCSIGRDHPDVHR 99 H I ++ + P + Y+LSG D + L++ EN + Q++ + H Sbjct: 96 HPDYIRSIAVHPTK-PYVLSGSDDLTVKLWNWENNWALEQTF--------------EGHE 140 Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNF----EETVYSHHMSPVSTK 155 + V V + P D F S D+T+KVW Q+ F E V P+ K Sbjct: 141 HFVMCVAFNPKDPSTFASGCLDRTVKVWSLG--QSTPNFTLTTGQERGVNYVDYYPLPDK 198 Query: 156 HCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 ++ + +++ D ++ SC L+GH + + P I+ + S D +K+W+ Sbjct: 199 PYMIT-ASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLP-IIISGSEDGTLKIWN 256 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 49/241 (20%), Positives = 83/241 (34%), Gaps = 46/241 (19%) Query: 159 VAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRR 218 + VG+ ++++ + +G + H I +++ P Y+L+ S D VKLW Sbjct: 70 IIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLS-GSDDLTVKLW---- 124 Query: 219 ASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVG-TDNRMRLWNS--- 274 N + + A+E H V + F G D +++W+ Sbjct: 125 -----------NWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQS 173 Query: 275 ------SNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQIT 328 + G+ VNY K T S TI ++ + + Sbjct: 174 TPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDL-----------TIKIWDYQTKSCVA 222 Query: 329 MLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDA 388 L+GH V VF + SGS D + W S Y+ + LN E + Sbjct: 223 TLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYK---------VEKTLNVGLERS 273 Query: 389 W 389 W Sbjct: 274 W 274 >3EI3-B nrPDB Length = 383 Score = 44.7 bits (104), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 27/91 (29%), Positives = 44/91 (48%), Gaps = 14/91 (15%) Query: 185 HRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAH 244 H+ ++ ++PR D+++AT+S D+ VKLWD+R K + A H Sbjct: 203 HKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNI-------------KDKNSYIAEMPH 249 Query: 245 NGKVNGLCFT-SDGLHLLTVGTDNRMRLWNS 274 VN F +D LLT N +R+++S Sbjct: 250 EKPVNAAYFNPTDSTKLLTTDQRNEIRVYSS 280 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 41/185 (22%), Positives = 73/185 (39%), Gaps = 15/185 (8%) Query: 97 VHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF----NFEETVYSHHMSPV 152 +H+ V ++ P + +SS D T+K+WD ++ + + E+ V + + +P Sbjct: 202 LHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPT 261 Query: 153 STKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQ----EILAVSWSPRYDYILATASAD 208 + L +V S I+ HRQ + +W P YD I+A D Sbjct: 262 DSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKATWHPMYDLIVAGRYPD 321 Query: 209 SRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNR 268 ++ L D R + D ++G + N A +N T D +L G Sbjct: 322 DQLLLNDKR----TIDIYDANSGGLVHQLRDPNAAGIISLNKFSPTGD---VLASGMGFN 374 Query: 269 MRLWN 273 + +WN Sbjct: 375 ILIWN 379 >5WLC-LO nrPDB Length = 923 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 55/202 (27%), Positives = 88/202 (43%), Gaps = 36/202 (17%) Query: 169 QLCDLKSGSCSHIL--QGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASG-CLIT 225 QL + S S+IL QGH ++++SP ++ TAS D ++K+WD+ SG CL T Sbjct: 326 QLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVV-TASEDGKIKVWDI--TSGFCLAT 382 Query: 226 LDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYG 285 ++H + +V + A G+V + + D +R W+ L+ Y Sbjct: 383 FEEH----TSSVTAVQFAKRGQV-----------MFSSSLDGTVRAWD-------LIRYR 420 Query: 286 KV-CNNSKKGLKFT-VSCGCSSEFVFVPYGST----IAVYTVYSGEQITMLKGHYKTVDC 339 + ++F ++ S E V GS I V++V +G+ + L GH V C Sbjct: 421 NFRTFTGTERIQFNCLAVDPSGEVVCA--GSLDNFDIHVWSVQTGQLLDALSGHEGPVSC 478 Query: 340 CVFQSNFQELYSGSRDCNILAW 361 F L S S D I W Sbjct: 479 LSFSQENSVLASASWDKTIRIW 500 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 40/175 (22%), Positives = 76/175 (43%), Gaps = 16/175 (9%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H N+L P +G +++ DG I ++D+ + C A + H S Sbjct: 344 HFDSTNSLAYSP-DGSRVVTASEDGKIKVWDITSG------FCLATF-------EEHTSS 389 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 V VQ+ MF SSS D T++ WD + F E + + ++ + + A Sbjct: 390 VTAVQFAKRGQVMF-SSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAG 448 Query: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 + + +++G L GH + +S+S + + +LA+AS D +++W + Sbjct: 449 SLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QENSVLASASWDKTIRIWSI 502 Score = 34.7 bits (78), Expect = 0.076, Method: Compositional matrix adjust. Identities = 71/361 (19%), Positives = 133/361 (36%), Gaps = 53/361 (14%) Query: 27 VLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKA 86 V L NK E H I +D+ +G ++S DG +L + + + ++ K Sbjct: 39 VFDLINNKSFTFEYEHRKNIAAIDLNK-QGTLLISIDEDGRAILVNFKARNVLHHFNFKE 97 Query: 87 VCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN--FEETV 144 CS + PD +++ +G F L++W T + F V Sbjct: 98 KCSAVKFSPDGRLFALA--------SGRF--------LQIWKTPDVNKDRQFAPFVRHRV 141 Query: 145 YSHHMSPVS-------TKHCLVAVGTRGPKVQLCDLKSGS-CSHILQGHRQEILAVSWSP 196 ++ H ++ ++ L K+ D + + + GHR ++ +S Sbjct: 142 HAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSH 201 Query: 197 RYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESAN-----------TAHN 245 + I T S D V +W+ + + + K + V+ + A+ Sbjct: 202 DQEKIY-TVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQ 260 Query: 246 GKVNGLCFTSDGLHLLTVG-TDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCS 304 KV + F LL VG T RL++ + TL+ + N TVS + Sbjct: 261 AKVKCVTFHP-ATRLLAVGFTSGEFRLYDLPDF--TLIQQLSMGQNPVN----TVSVNQT 313 Query: 305 SEFVFVPYGST----IAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA 360 E ++ +GS+ + VY S I +GH+ + + + + + + S D I Sbjct: 314 GE--WLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKV 371 Query: 361 W 361 W Sbjct: 372 W 372 >4PSX-B nrPDB Length = 401 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 44/186 (23%), Positives = 83/186 (44%), Gaps = 25/186 (13%) Query: 54 VEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG 113 V+GR +LSG D + L+++ + + K V R D+H + +W+ + Sbjct: 172 VKGR-LLSGSDDHTVALWEVGSGGDPT----KPV----RTWNDLHSDIINDNKWHNFNKD 222 Query: 114 MFTSSSFDKTLKVWDT-------NTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGP 166 +F + S D LK+ D +T++ FN +SHH S L+A Sbjct: 223 LFGTVSEDSLLKINDVRANNTTIDTVKCPQPFN--TLAFSHHSS------NLLAAAGMDS 274 Query: 167 KVQLCDLKS-GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLIT 225 V L DL++ H + GH + + +S D ++ ++ +D+R+ +WD+++ Sbjct: 275 YVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTP 334 Query: 226 LDQHNG 231 D +G Sbjct: 335 DDAEDG 340 Score = 29.3 bits (64), Expect = 2.8, Method: Compositional matrix adjust. Identities = 33/174 (18%), Positives = 59/174 (33%), Gaps = 52/174 (29%) Query: 46 INTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETV 105 NTL + + G D + LYDL N ++ H +V + Sbjct: 254 FNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSG------------HEDAVNNL 301 Query: 106 QWYPHDTGMFTSSSFDKTLKVWDTNTL---QTADVFNFEETVYSHHMSPVSTKHCLVAVG 162 ++ H G+ SS D L +WD + QT D Sbjct: 302 EFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPD-------------------------- 335 Query: 163 TRGPKVQLCDLKSGSCSHIL--QGHRQEILAVSWSPRYDYILATASADSRVKLW 214 D + G I+ GHR + +P+ +++A+A ++ +++W Sbjct: 336 ---------DAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 >5I2T-A nrPDB Length = 742 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 55/202 (27%), Positives = 88/202 (43%), Gaps = 36/202 (17%) Query: 169 QLCDLKSGSCSHIL--QGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASG-CLIT 225 QL + S S+IL QGH ++++SP ++ TAS D ++K+WD+ SG CL T Sbjct: 351 QLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVV-TASEDGKIKVWDI--TSGFCLAT 407 Query: 226 LDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYG 285 ++H + +V + A G+V + + D +R W+ L+ Y Sbjct: 408 FEEH----TSSVTAVQFAKRGQV-----------MFSSSLDGTVRAWD-------LIRYR 445 Query: 286 KV-CNNSKKGLKFT-VSCGCSSEFVFVPYGST----IAVYTVYSGEQITMLKGHYKTVDC 339 + ++F ++ S E V GS I V++V +G+ + L GH V C Sbjct: 446 NFRTFTGTERIQFNCLAVDPSGEVVCA--GSLDNFDIHVWSVQTGQLLDALSGHEGPVSC 503 Query: 340 CVFQSNFQELYSGSRDCNILAW 361 F L S S D I W Sbjct: 504 LSFSQENSVLASASWDKTIRIW 525 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 40/175 (22%), Positives = 75/175 (42%), Gaps = 16/175 (9%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H N+L P +G +++ DG I ++D+ + C A + H S Sbjct: 369 HFDSTNSLAYSP-DGSRVVTASEDGKIKVWDITSG------FCLATF-------EEHTSS 414 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 V VQ+ MF SSS D T++ WD + F E + + ++ + + A Sbjct: 415 VTAVQFAKRGQVMF-SSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAG 473 Query: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 + + +++G L GH + +S+S + +LA+AS D +++W + Sbjct: 474 SLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQE-NSVLASASWDKTIRIWSI 527 Score = 34.7 bits (78), Expect = 0.071, Method: Compositional matrix adjust. Identities = 52/246 (21%), Positives = 87/246 (35%), Gaps = 66/246 (26%) Query: 27 VLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKA 86 V L NK E H I +D+ +G ++S DG +L + + + ++ K Sbjct: 64 VFDLINNKSFTFEYEHRKNIAAIDLNK-QGTLLISIDEDGRAILVNFKARNVLHHFNFKE 122 Query: 87 VCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYS 146 CS + PD +++ + G F L++W T + F Sbjct: 123 KCSAVKFSPDGRLFALAS--------GRF--------LQIWKTPDVNKDRQF-------- 158 Query: 147 HHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATAS 206 P V+ + GH Q+I +++WS +IL T S Sbjct: 159 ------------------APFVR---------HRVHAGHFQDITSLTWSQDSRFIL-TTS 190 Query: 207 ADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTD 266 D K+W V + +K+ A + N H V G F+ D + TV D Sbjct: 191 KDLSAKIWSV------------DSEEKNLAATTFN-GHRDYVMGAFFSHDQEKIYTVSKD 237 Query: 267 NRMRLW 272 + +W Sbjct: 238 GAVFVW 243 >5A31-R nrPDB Length = 386 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 40/164 (24%), Positives = 77/164 (46%), Gaps = 25/164 (15%) Query: 59 MLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTS- 117 + SGG+D V+ +Y E +S+ T D H+ +V+ + W PH G+ + Sbjct: 229 LASGGNDNVVHVY--EGTSKSPILTF-----------DEHKAAVKAMAWSPHKRGVLATG 275 Query: 118 -SSFDKTLKVWDTNT-LQTADVFNFEET---VYSHHMSPVSTKHCLVAVGTRGPKVQLCD 172 + D+ LK+W+ NT ++ +D+ + + V+S + + + T H G + L D Sbjct: 276 GGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSH-----GYSKYNLTLWD 330 Query: 173 LKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 S IL+GH +L ++ S +++ A D ++ W + Sbjct: 331 CNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGA-GDETLRYWKL 373 Score = 36.6 bits (83), Expect = 0.017, Method: Compositional matrix adjust. Identities = 49/237 (20%), Positives = 89/237 (37%), Gaps = 45/237 (18%) Query: 159 VAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRR 218 +AVG V++ D+ C L GH + +SW+ +++L + S D R+ DVR Sbjct: 146 LAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN---NHVLTSGSRDHRILHRDVRM 202 Query: 219 ASGCLITLDQH---------NGKKSQAVESAN------------------TAHNGKVNGL 251 T++ H N ++ N H V + Sbjct: 203 PDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAM 262 Query: 252 CFTSDGLHLLTVG---TDNRMRLW--NSSNGENTLVNYGKVCNN--SKKGLKFTVSCGCS 304 ++ +L G D R+++W N+S + + + ++CN SK + S G S Sbjct: 263 AWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYS 322 Query: 305 SEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 + ++ S + I +LKGH V ++ + SG+ D + W Sbjct: 323 KY--------NLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYW 371 >4BH6-A nrPDB Length = 308 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 49/215 (22%), Positives = 89/215 (41%), Gaps = 45/215 (20%) Query: 8 RQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGV 67 R + DP T+ V GL+ N V + SGG+D V Sbjct: 129 RDVRMPDPFFETIESHTQEVCGLKWN--------------------VADNKLASGGNDNV 168 Query: 68 IVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTS--SSFDKTLK 125 + +Y E +S+ T D H+ +V+ + W PH G+ + + D+ LK Sbjct: 169 VHVY--EGTSKSPILTF-----------DEHKAAVKAMAWSPHKRGVLATGGGTADRRLK 215 Query: 126 VWDTNT-LQTADVFNFEET---VYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHI 181 +W+ NT ++ +D+ + + V+S + + + T H G + L D S I Sbjct: 216 IWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSH-----GYSKYNLTLWDCNSMDPIAI 270 Query: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 L+GH +L ++ S +++ A D ++ W + Sbjct: 271 LKGHSFRVLHLTLSNDGTTVVSGA-GDETLRYWKL 304 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 49/237 (20%), Positives = 89/237 (37%), Gaps = 45/237 (18%) Query: 159 VAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRR 218 +AVG V++ D+ C L GH + +SW+ +++L + S D R+ DVR Sbjct: 77 LAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN---NHVLTSGSRDHRILHRDVRM 133 Query: 219 ASGCLITLDQH---------NGKKSQAVESAN------------------TAHNGKVNGL 251 T++ H N ++ N H V + Sbjct: 134 PDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAM 193 Query: 252 CFTSDGLHLLTVG---TDNRMRLW--NSSNGENTLVNYGKVCNN--SKKGLKFTVSCGCS 304 ++ +L G D R+++W N+S + + + ++CN SK + S G S Sbjct: 194 AWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYS 253 Query: 305 SEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 + ++ S + I +LKGH V ++ + SG+ D + W Sbjct: 254 KY--------NLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYW 302 >5L9T-R nrPDB Length = 493 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 35/124 (28%), Positives = 60/124 (48%), Gaps = 17/124 (13%) Query: 153 STKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVK 212 S + LVAVGT VQ+ D +G +L+GH + A++W+ L++ S D + Sbjct: 238 SERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ---LSSGSRDRMIL 294 Query: 213 LWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLW 272 D+R T + ++ Q H +V GL +++D L + G DN++ +W Sbjct: 295 QRDIR-------TPPLQSERRLQ-------GHRQEVCGLKWSTDHQLLASGGNDNKLLVW 340 Query: 273 NSSN 276 N S+ Sbjct: 341 NHSS 344 Score = 31.2 bits (69), Expect = 0.84, Method: Compositional matrix adjust. Identities = 35/150 (23%), Positives = 59/150 (39%), Gaps = 29/150 (19%) Query: 153 STKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILAT--ASADSR 210 ST H L+A G K+ + + S S H + A++WSP +LA+ +AD Sbjct: 322 STDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRC 381 Query: 211 VKLWDVRRAS--GCLITLDQ----------------HNGKKSQAV---------ESANTA 243 ++ W+ C+ T Q H ++Q + + T Sbjct: 382 IRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTG 441 Query: 244 HNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 H+ +V L + DG ++T D +R WN Sbjct: 442 HSYRVLYLAMSPDGEAIVTGAGDETLRFWN 471 >5OPT-p nrPDB Length = 318 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 45/174 (25%), Positives = 82/174 (47%), Gaps = 33/174 (18%) Query: 117 SSSFDKTLKVWDTNTLQTADV--FNFEETVYSHHMSPVSTKHCLVAVGTRGP-------- 166 S+S D TL W +N + ++ + F E H + VS VA+ G Sbjct: 33 STSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSD----VALSNNGDFAVSASWD 88 Query: 167 -KVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLIT 225 ++L +L++G C H GH +++L+V++SP I+ + D+ +++W+V+ CL T Sbjct: 89 HSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIV-SGGRDNALRVWNVK--GECLHT 145 Query: 226 LDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTV--GTDNRMRLWNSSNG 277 L + AH V+ + F+ L V G DN +++W+ ++G Sbjct: 146 LGR-------------GAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASG 186 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 46/167 (27%), Positives = 78/167 (46%), Gaps = 26/167 (15%) Query: 117 SSSFDKTLKVWDTNTLQTADVF-NFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKS 175 S+S+D +L++W+ T F + V S SP + + + G R +++ ++K Sbjct: 84 SASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQ---IVSGGRDNALRVWNVK- 139 Query: 176 GSCSHILQ--GHRQEILAVSWSPRYDY-ILATASADSRVKLWDVRRASGCLIT-LDQHNG 231 G C H L H + V +SP + ++ + D+ VK+WD+ ASG L+T L H Sbjct: 140 GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDI--ASGRLLTDLKGH-- 195 Query: 232 KKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 + + S + +G LC +SD D RLW+ + GE Sbjct: 196 --TNYITSVTVSPDGS---LCASSD--------KDGVARLWDLTKGE 229 Score = 32.0 bits (71), Expect = 0.46, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 82/213 (38%), Gaps = 40/213 (18%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN--TLQTADVFNFEETVYSHHMSPVSTK 155 H V +V + P D S D L+VW+ L T + V SP S + Sbjct: 108 HTKDVLSVTFSP-DNRQIVSGGRDNALRVWNVKGECLHTLGRGAHTDWVSCVRFSP-SLE 165 Query: 156 HCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 L+ G V++ D+ SG L+GH I +V+ SP + A++ D +LWD Sbjct: 166 TPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSPD-GSLCASSDKDGVARLWD 224 Query: 216 VRR-------ASGCLIT---------------------LDQHNGKKSQAVESANTAHNG- 246 + + A+G I D N K VE A A Sbjct: 225 LTKGEALSEMAAGAPINQICFSPNRYWMCAATEKGIRIFDLEN--KDVIVELAPEAQQKS 282 Query: 247 ----KVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 + + +++DG L + TDN +R+W+ S Sbjct: 283 KKTPECMSIAWSADGNTLYSGYTDNVIRVWSVS 315 >5BJS-A nrPDB Length = 605 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 29/122 (23%), Positives = 55/122 (45%), Gaps = 11/122 (9%) Query: 151 PVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSR 210 P++ + L G G V++ ++ G L GH I ++ SP YI+A+AS D+ Sbjct: 144 PITDQPLLCIAGNEG-NVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTT 202 Query: 211 VKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMR 270 +++W +L + K+ H+ + + F +G ++L+ G D + Sbjct: 203 IRIW----------SLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVIN 252 Query: 271 LW 272 LW Sbjct: 253 LW 254 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 24/87 (27%), Positives = 38/87 (43%), Gaps = 10/87 (11%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 HGGGIN L P + S D I ++ L + VC +G + H Y Sbjct: 177 HGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQ----PCVCILGGEG---HSYD 229 Query: 102 VETVQWYPHDTGMFT-SSSFDKTLKVW 127 + +V + HD G + S+ D+ + +W Sbjct: 230 LLSVAF--HDNGRYVLSAGHDQVINLW 254 >3DM0-A nrPDB Length = 694 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 67/261 (25%), Positives = 110/261 (42%), Gaps = 55/261 (21%) Query: 55 EGRYMLSGGSDGVIVLYDLEN--SSRQSYYTCKAVCSIG------------RDHP----- 95 +G++ LSG DG + L+DL S+R+ K V S+ RD Sbjct: 441 DGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASRDRTIKLWN 500 Query: 96 -------------DVHRYSVETVQWYPHD-TGMFTSSSFDKTLKVWDTNTLQTADVFNFE 141 + HR V V++ P+ S+S+DKT+KVW+ + + Sbjct: 501 TLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCK------LR 554 Query: 142 ETVYSH----HMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPR 197 T+ H VS L A G + V L DL G + L+ + I A+ +SP Sbjct: 555 STLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEAN-SVIHALCFSPN 613 Query: 198 YDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANT---AHNGKV---NGL 251 ++ A+ + +K+WD+ S I D K++A ++ N+ A KV L Sbjct: 614 RYWL--CAATEHGIKIWDLESKS---IVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSL 668 Query: 252 CFTSDGLHLLTVGTDNRMRLW 272 +++DG L + TD +R+W Sbjct: 669 NWSADGSTLFSGYTDGVIRVW 689 Score = 32.0 bits (71), Expect = 0.44, Method: Compositional matrix adjust. Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 1/57 (1%) Query: 22 ESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSR 78 + T +V L K R H G ++T+ + P +G SGG DGV++L+DL + Sbjct: 540 DKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSP-DGSLCASGGKDGVVLLWDLAEGKK 595 Score = 32.0 bits (71), Expect = 0.50, Method: Compositional matrix adjust. Identities = 39/185 (21%), Positives = 72/185 (38%), Gaps = 21/185 (11%) Query: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESAN 241 ++ H + A++ I+ +AS D + LW + + + K + Sbjct: 378 MRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTK-----------DDKAYGVAQRRL 426 Query: 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSC 301 T H+ V + +SDG L+ D +RLW+ + G +T + ++K L S Sbjct: 427 TGHSHFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTR----RFVGHTKDVLSVAFSL 482 Query: 302 GCSSEFVFVPYGSTIAVYTVYSGEQITML---KGHYKTVDCCVFQSNFQE--LYSGSRDC 356 + + V TI ++ + T+ +GH V C F N + + S S D Sbjct: 483 D-NRQIVSASRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDK 541 Query: 357 NILAW 361 + W Sbjct: 542 TVKVW 546 >6EOJ-D nrPDB Length = 470 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 34/149 (22%), Positives = 61/149 (40%), Gaps = 28/149 (18%) Query: 148 HMSPVSTKHCLVA-----------VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSP 196 H+S KH + A V T + L + S + ++Q H + + +S Sbjct: 86 HLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSH 145 Query: 197 RYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD 256 D+++ + AD +K+W Q N V+ + AH + + F+S+ Sbjct: 146 DSDWMI-SGDADGMIKIW-------------QPNF---SMVKEIDAAHTESIRDMAFSSN 188 Query: 257 GLHLLTVGTDNRMRLWNSSNGENTLVNYG 285 +T DN +++WN SNG+ V G Sbjct: 189 DSKFVTCSDDNILKIWNFSNGKQERVLSG 217 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 51/253 (20%), Positives = 97/253 (38%), Gaps = 62/253 (24%) Query: 58 YMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTS 117 +M+SG +DG+I ++ + ++ K + + H S+ + + +D+ F + Sbjct: 149 WMISGDADGMIKIW------QPNFSMVKEIDA-------AHTESIRDMAFSSNDSK-FVT 194 Query: 118 SSFDKTLKVWD-TNTLQTADVFNFEETVYSHHMSPVSTKHC-------LVAVGTRGPKVQ 169 S D LK+W+ +N Q E + HH K C L+A ++ V+ Sbjct: 195 CSDDNILKIWNFSNGKQ-------ERVLSGHHWD---VKSCDWHPEMGLIASASKDNLVK 244 Query: 170 LCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR---------RAS 220 L D +SG+C + + +L + P +L S D +++D+R R Sbjct: 245 LWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDE 304 Query: 221 GCLITLDQHNGKKS---------------------QAVESANTAHNGKVNGLCFTSDGLH 259 +TL+ H +S + + + AH+ + L + G Sbjct: 305 TDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHI 364 Query: 260 LLTVGTDNRMRLW 272 T D +R W Sbjct: 365 FATAAKDRTIRFW 377 Score = 35.0 bits (79), Expect = 0.055, Method: Compositional matrix adjust. Identities = 33/178 (18%), Positives = 69/178 (38%), Gaps = 22/178 (12%) Query: 186 RQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHN 245 + I A+ W+P L A+ LW+ S E+ AH+ Sbjct: 93 KHVIPAIQWTPE-GRRLVVATYSGEFSLWNA----------------SSFTFETLMQAHD 135 Query: 246 GKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSS 305 V + ++ D +++ D +++W + ++ S + + F+ + S Sbjct: 136 SAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHT--ESIRDMAFSSN---DS 190 Query: 306 EFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVP 363 +FV + + ++ +G+Q +L GH+ V C + + S S+D + W P Sbjct: 191 KFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDP 248 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 19/78 (24%), Positives = 38/78 (48%), Gaps = 13/78 (16%) Query: 51 IEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPH 110 +P +G +++ D ++D+ Y+ K + + RD D T++W+P Sbjct: 269 FQPTKGNLLMAISKDKSCRVFDIR-------YSMKELMCV-RDETDYM-----TLEWHPI 315 Query: 111 DTGMFTSSSFDKTLKVWD 128 + MFT + +D +LK +D Sbjct: 316 NESMFTLACYDGSLKHFD 333 >2AQ5-A nrPDB Length = 402 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 29/104 (27%), Positives = 44/104 (42%), Gaps = 20/104 (19%) Query: 184 GHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCL------ITLDQHNGKKSQAV 237 GH +L ++W P D ++A+ S D V +W++ L ITL+ H K+ V Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHT-KRVGIV 137 Query: 238 ESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTL 281 TA N LL+ G DN + +W+ G L Sbjct: 138 AWHPTAQN-------------VLLSAGCDNVILVWDVGTGAAVL 168 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 35/180 (19%), Positives = 59/180 (32%), Gaps = 51/180 (28%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHC 157 H V + W PH+ + S S D T+ VW+ V E V + Sbjct: 80 HTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIP--DGGLVLPLREPVIT----------- 126 Query: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 L+GH + + V+W P +L +A D+ + +WDV Sbjct: 127 ------------------------LEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDV- 161 Query: 218 RASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNG 277 G + + H + + ++ DG + T D R+R+ G Sbjct: 162 -------------GTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKG 208 Score = 33.1 bits (74), Expect = 0.24, Method: Compositional matrix adjust. Identities = 56/265 (21%), Positives = 94/265 (35%), Gaps = 80/265 (30%) Query: 28 LGLELNKDRDVERIHGGGINTLDIE--PVEGRYMLSGGSDGVIVLYDLENSS-----RQS 80 LG D++V + G LDI P + SG D ++++++ + R+ Sbjct: 64 LGKTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREP 123 Query: 81 YYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNF 140 T + H V V W+P + S+ D + VWD T Sbjct: 124 VITLEG-----------HTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGT--------- 163 Query: 141 EETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDY 200 AV T GP V H I +V WS R Sbjct: 164 -----------------GAAVLTLGPDV----------------HPDTIYSVDWS-RDGA 189 Query: 201 ILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHL 260 ++ T+ D RV++ + R+ G ++ +K + E H F S+G + Sbjct: 190 LICTSCRDKRVRVIEPRK--GTVV------AEKDRPHEGTRPVHA------VFVSEG-KI 234 Query: 261 LTVG----TDNRMRLWNSSNGENTL 281 LT G ++ ++ LW++ + E L Sbjct: 235 LTTGFSRMSERQVALWDTKHLEEPL 259 >5OQL-L nrPDB Length = 557 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 44/198 (22%), Positives = 80/198 (40%), Gaps = 28/198 (14%) Query: 167 KVQLCDLKSGSCSHILQG---HRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCL 223 ++Q+ D+ G+ + IL+ H+Q + WSP L + S D V+LWD+ Sbjct: 122 RMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDL------- 174 Query: 224 ITLDQHNGKKSQAVESANTAHNGKVNGLCFT--SDGLHLLTVGT-DNRMRLWNSSNGENT 280 S T H V F S +LL G+ D +R+W++ Sbjct: 175 ---------PSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGA 225 Query: 281 LVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCC 340 ++ + K + + L S + G+ I+V + + + + ++ H KTV Sbjct: 226 VMTF-KHADPIEDVLPLP-----SGTTLLAASGNAISVLDLVAAKPLRLITNHQKTVTSL 279 Query: 341 VFQSNFQELYSGSRDCNI 358 S + + SGS D ++ Sbjct: 280 SLASQGRRVVSGSLDGHV 297 Score = 35.0 bits (79), Expect = 0.064, Method: Compositional matrix adjust. Identities = 47/229 (20%), Positives = 89/229 (38%), Gaps = 32/229 (13%) Query: 50 DIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYP 109 +I P +GR +++G G + ++D+ +R +H+ V +W P Sbjct: 106 EIRP-DGRVLVAGEDTGRMQVFDVGQGTRAVILKTW----------HIHKQPVWVTKWSP 154 Query: 110 HDTGMFTSSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTKHCLVAVGTRGPKV 168 + S S DKT+++WD + +F + V P S L+ G+ V Sbjct: 155 TELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETV 214 Query: 169 QLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLIT-LD 227 ++ D ++ + + H I V P +LA ASG I+ LD Sbjct: 215 RVWDARAPGGAVMTFKHADPIEDVLPLPSGTTLLA---------------ASGNAISVLD 259 Query: 228 QHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN 276 K + + T H V L S G +++ D ++++ +++ Sbjct: 260 LVAAKPLRLI----TNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTS 304 >5K1B-B nrPDB Length = 677 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 39/164 (23%), Positives = 65/164 (39%), Gaps = 20/164 (12%) Query: 202 LATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLL 261 L +AS+D+ VK+W+ + C+ TL H V L + D + Sbjct: 90 LISASSDTTVKVWNAHKGF-CMSTL---------------RTHKDYVKALAYAKDKELVA 133 Query: 262 TVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTV-SCGCSSEFVFVPYGSTIAVYT 320 + G D ++ LW+ + + V +S G K ++ S + + GST V Sbjct: 134 SAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLR 193 Query: 321 VYSGE---QITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 V+ ++ LKGH V + + + SGS D I W Sbjct: 194 VWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLW 237 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 47/254 (18%), Positives = 102/254 (40%), Gaps = 49/254 (19%) Query: 19 RRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSR 78 R+ + RR + + +VE+ + G+N L ++P R + + G D +I ++ + + Sbjct: 6 RQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNR-LFTAGRDSIIRIWSVNQHKQ 64 Query: 79 QSYYTC-----------------KAVCSIGRDHP---------------DVHRYSVETVQ 106 Y K + S D H+ V+ + Sbjct: 65 DPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALA 124 Query: 107 WYPHDTGMFTSSSFDKTLKVWDTNTL----------QTADVFNFEETVYSHHMSPVSTKH 156 Y D + S+ D+ + +WD NTL T+ + ++++YS M+ + T Sbjct: 125 -YAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGT-- 181 Query: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 ++ G+ +++ D ++ + L+GH + A+ + R + S+D ++LW + Sbjct: 182 -IIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLN-RDGTQCLSGSSDGTIRLWSL 239 Query: 217 RRASGCLITLDQHN 230 + C+ T H+ Sbjct: 240 GQQR-CIATYRVHD 252 >4V8M-A7 nrPDB Length = 318 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 47/167 (28%), Positives = 78/167 (46%), Gaps = 26/167 (15%) Query: 117 SSSFDKTLKVWDTNTLQTADVF-NFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKS 175 S+S+D +L++W+ Q F + V S SP + + + G R +++ ++K Sbjct: 84 SASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQ---IVSGGRDNALRVWNVK- 139 Query: 176 GSCSHILQ--GHRQEILAVSWSPRYDY-ILATASADSRVKLWDVRRASGCLIT-LDQHNG 231 G C H L H + V +SP D ++ + D+ VK+WD+ A+G L+T L H Sbjct: 140 GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDL--ATGRLVTDLKGH-- 195 Query: 232 KKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 + V S + +G LC +SD D RLW+ + GE Sbjct: 196 --TNYVTSVTVSPDGS---LCASSD--------KDGVARLWDLTKGE 229 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 42/183 (22%), Positives = 82/183 (44%), Gaps = 33/183 (18%) Query: 109 PHDTGMFTSSSFDKTLKVWDTNTLQTAD--VFNFEETVYSHHMSPVSTKHCLVAVGTRGP 166 P S+S DKTL W N + + + + H + VS VA+ G Sbjct: 25 PETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSD----VALSNNGN 80 Query: 167 ---------KVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 ++L +L++G C + GH +++L+V++SP I+ + D+ +++W+V+ Sbjct: 81 FAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIV-SGGRDNALRVWNVK 139 Query: 218 RASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS--DGLHLLTVGTDNRMRLWNSS 275 C+ TL + AH V+ + F+ D +++ G DN +++W+ + Sbjct: 140 --GECMHTLSR-------------GAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLA 184 Query: 276 NGE 278 G Sbjct: 185 TGR 187 Score = 37.0 bits (84), Expect = 0.016, Method: Compositional matrix adjust. Identities = 52/224 (23%), Positives = 94/224 (41%), Gaps = 31/224 (13%) Query: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPH-DTG 113 + R ++SGG D + +++++ C S G H V V++ P D Sbjct: 120 DNRQIVSGGRDNALRVWNVKGE-------CMHTLSRG-----AHTDWVSCVRFSPSLDAP 167 Query: 114 MFTSSSFDKTLKVWDTNTLQ-TADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCD 172 + S +D +KVWD T + D+ V S +SP + L A + +L D Sbjct: 168 VIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSPDGS---LCASSDKDGVARLWD 224 Query: 173 LKSG-SCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNG 231 L G + S + G I + +SP ++ A + + ++++D+ + +H G Sbjct: 225 LTKGEALSEMAAG--APINQICFSPNRYWMCA--ATEKGIRIFDLENKDIIVELAPEHQG 280 Query: 232 KKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 K E + A +++DG L + TDN +R+W S Sbjct: 281 SKKIVPECVSIA---------WSADGSTLYSGYTDNVIRVWGVS 315 >3W15-A nrPDB Length = 368 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 19/80 (23%), Positives = 37/80 (46%), Gaps = 2/80 (2%) Query: 48 TLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQW 107 T D + +GG D I ++D+ ++ + C + P+ H ++ V W Sbjct: 227 TCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCI--NEIPNAHGLAIRKVTW 284 Query: 108 YPHDTGMFTSSSFDKTLKVW 127 PH + + S+S+D T ++W Sbjct: 285 SPHHSNILMSASYDMTCRIW 304 Score = 33.5 bits (75), Expect = 0.15, Method: Compositional matrix adjust. Identities = 51/244 (20%), Positives = 87/244 (35%), Gaps = 41/244 (16%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWD---TNTLQTADVFNFEET----------- 143 H V + W + F SSS+D ++K+W +L T E T Sbjct: 105 HEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIIL 164 Query: 144 --------------VYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHR-QE 188 VY SP L G + L SG + H E Sbjct: 165 KKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLE 224 Query: 189 ILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGK--KSQAVESANTAHNG 246 L ++ Y++AT D+ +++WD+R L+++ G+ S + AH Sbjct: 225 ALTCDFNKYRPYVVATGGVDNAIRIWDIR-------MLNKNPGQLHNSSCINEIPNAHGL 277 Query: 247 KVNGLCFTSDGLH-LLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSS 305 + + ++ + L++ D R+W + + Y ++ KG F + S Sbjct: 278 AIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFT--QHS 335 Query: 306 EFVF 309 EFVF Sbjct: 336 EFVF 339 >5WLC-LJ nrPDB Length = 513 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 63/291 (21%), Positives = 113/291 (38%), Gaps = 55/291 (18%) Query: 70 LYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDT 129 L + + Q Y+ + ++H V S +PHD + +S+ ++++ + Sbjct: 15 LLPQQTTPEQRYWRQYTSAQLVKEHNSVTHISFNP--QHPHDFAVTSSTR----VQIFSS 68 Query: 130 NTLQTADVFN-FEETVYSHHMSPVSTKHC------LVAV-GTRGPKVQLCDLKSGS-CSH 180 T Q F+ F++ VYS C LV+V + P+ L + + + +H Sbjct: 69 RTRQVIKTFSRFKDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTH 128 Query: 181 ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA 240 + + H Q+ + ILATAS D +LWD+ A + L Sbjct: 129 VTKFHTQD----------NKILATASDDRVTRLWDISNAYEPQLEL-------------- 164 Query: 241 NTAHNGKVNGLCFTSDGLHLLTVGT-DNRMRLWNSSNGENTLV---NYGKVCNNS-KKGL 295 T V L F HL+ G+ D +RL+++ + +T + N+ + N Sbjct: 165 -TGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVENVIAVSP 223 Query: 296 KFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNF 346 VSCG G+ V+ + S +++ K V C + NF Sbjct: 224 TQIVSCG----------GNNFKVWDLTSNKKLYERGNFNKAVTCLDYVENF 264 Score = 31.6 bits (70), Expect = 0.55, Method: Compositional matrix adjust. Identities = 27/128 (21%), Positives = 54/128 (42%), Gaps = 14/128 (10%) Query: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSI-GRDHPDVHRYSVETVQWYPHDTG 113 +G+ + +G + G++ +YD SY + SI HP +++ D Sbjct: 92 DGKLLCAGDATGLVSVYD-------SYNPRTILLSINASTHP------THVTKFHTQDNK 138 Query: 114 MFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDL 173 + ++S D+ ++WD + + T Y +S + LVA G+ ++L D Sbjct: 139 ILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDT 198 Query: 174 KSGSCSHI 181 +S + I Sbjct: 199 RSSGSTPI 206 >6GMH-W nrPDB Length = 305 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/178 (24%), Positives = 80/178 (44%), Gaps = 24/178 (13%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDT-NTLQTADVFNFEETVYSHHMSPVSTKH 156 H+ V +V H + SSS D +++WD N Q + ++ SP S Sbjct: 63 HQLGVVSVD-ISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQ-- 119 Query: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 +A GT KV + ++SG + L + IL++++SP Y LA+ + D + ++D+ Sbjct: 120 -YLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKY-LASGAIDGIINIFDI 177 Query: 217 RRASGCLI-TLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 A+G L+ TL+ H + L F+ D L+T D +++++ Sbjct: 178 --ATGKLLHTLE---------------GHAMPIRSLTFSPDSQLLVTASDDGYIKIYD 218 Score = 27.7 bits (60), Expect = 9.4, Method: Compositional matrix adjust. Identities = 22/104 (21%), Positives = 49/104 (47%), Gaps = 15/104 (14%) Query: 27 VLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKA 86 + G+E K G I ++ P +G+Y+ SG DG+I ++D+ ++ + +T + Sbjct: 132 IFGVESGKKEYSLDTRGKFILSIAYSP-DGKYLASGAIDGIINIFDI--ATGKLLHTLEG 188 Query: 87 VCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN 130 H + ++ + P D+ + ++S D +K++D Sbjct: 189 -----------HAMPIRSLTFSP-DSQLLVTASDDGYIKIYDVQ 220 >6N9G-C nrPDB Length = 353 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 46/198 (23%), Positives = 76/198 (38%), Gaps = 28/198 (14%) Query: 170 LCDLKSGSCSHILQGHRQEILAVSWSP-RYDYILATASADSRVKLWDVRRASGCLITLDQ 228 L D++SG GH ++L + +P + D + +WD+R Sbjct: 179 LWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMR----------- 227 Query: 229 HNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVC 288 +G+ QA E+ H VN + + G + D RL++ L +V Sbjct: 228 -SGQCVQAFET----HESDVNSVRYYPSGDAFASGSDDATCRLYD-------LRADREVA 275 Query: 289 NNSKKGLKF---TVSCGCSSEFVFVPYGS-TIAVYTVYSGEQITMLKGHYKTVDCCVFQS 344 SK+ + F +V S +F Y TI V+ V G ++++L GH V Sbjct: 276 IYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSP 335 Query: 345 NFQELYSGSRDCNILAWV 362 + SGS D + W Sbjct: 336 DGTAFCSGSWDHTLRVWA 353 Score = 29.6 bits (65), Expect = 2.4, Method: Compositional matrix adjust. Identities = 45/213 (21%), Positives = 79/213 (37%), Gaps = 50/213 (23%) Query: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKLWD--------------------VRRASG 221 L+GH ++L + W I+++ S D +V +WD SG Sbjct: 59 LKGHGNKVLCMDWCKDKRRIVSS-SQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 117 Query: 222 CLITLDQHNGKKS------------QAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRM 269 C I + K S A + + H ++ FT+ + +LT D Sbjct: 118 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 177 Query: 270 RLWNSSNGENTLVNYGK----VCNN---SKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVY 322 LW+ +G+ +G +C + S+ G F VS GC + + V+ + Sbjct: 178 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTF-VSGGCDKKAM---------VWDMR 227 Query: 323 SGEQITMLKGHYKTVDCCVFQSNFQELYSGSRD 355 SG+ + + H V+ + + SGS D Sbjct: 228 SGQCVQAFETHESDVNSVRYYPSGDAFASGSDD 260 Score = 29.3 bits (64), Expect = 2.8, Method: Compositional matrix adjust. Identities = 25/83 (30%), Positives = 39/83 (46%), Gaps = 15/83 (18%) Query: 45 GINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVET 104 G +++D + GR + +G +D I ++D+ SR S G H V T Sbjct: 285 GASSVDF-SLSGRLLFAGYNDYTINVWDVLKGSRVSIL-------FG------HENRVST 330 Query: 105 VQWYPHDTGMFTSSSFDKTLKVW 127 ++ P T F S S+D TL+VW Sbjct: 331 LRVSPDGTA-FCSGSWDHTLRVW 352 >5UZ7-B nrPDB Length = 351 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 47/192 (24%), Positives = 76/192 (39%), Gaps = 33/192 (17%) Query: 111 DTGMFTSSSFDKTLKVWDTNTLQTADVFNFEE-TVYSHHMSPVSTKHCLVAVGTRGPKVQ 169 D +SS D T +WD T Q F V S ++P + L G + Sbjct: 164 DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR---LFVSGACDASAK 220 Query: 170 LCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR------------ 217 L D++ G C GH +I A+ + P + AT S D+ +L+D+R Sbjct: 221 LWDVREGMCRQTFTGHESDINAICFFPNGN-AFATGSDDATCRLFDLRADQELMTYSHDN 279 Query: 218 ----------RASGCLITL--DQHNGKKSQAVESANTA----HNGKVNGLCFTSDGLHLL 261 SG L+ D N A+++ H+ +V+ L T DG+ + Sbjct: 280 IICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVA 339 Query: 262 TVGTDNRMRLWN 273 T D+ +++WN Sbjct: 340 TGSWDSFLKIWN 351 Score = 36.6 bits (83), Expect = 0.020, Method: Compositional matrix adjust. Identities = 40/178 (22%), Positives = 69/178 (38%), Gaps = 22/178 (12%) Query: 185 HRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAH 244 H +++++S +P + + + D+ KLWDVR C T T H Sbjct: 194 HTGDVMSLSLAPDT-RLFVSGACDASAKLWDVREGM-CRQTF---------------TGH 236 Query: 245 NGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCS 304 +N +CF +G T D RL++ + L+ Y +N G+ +VS S Sbjct: 237 ESDINAICFFPNGNAFATGSDDATCRLFDL-RADQELMTYSH--DNIICGIT-SVSFSKS 292 Query: 305 SEFVFVPYGS-TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 + Y V+ ++ +L GH V C + + +GS D + W Sbjct: 293 GRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 350 >5FA5-B nrPDB Length = 367 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 42/163 (25%), Positives = 58/163 (35%), Gaps = 18/163 (11%) Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMF 115 G +SG D I ++DL S Y H V V PH +F Sbjct: 162 GTQAVSGSKDICIKVWDLAQQVVLSSYR-------------AHAAQVTCVAASPHKDSVF 208 Query: 116 TSSSFDKTLKVWDTNTLQTADVFNFEETVY---SHHMSPVSTKHCLVAVGTRGPKVQLCD 172 S S D + +WDT + A Y S P ++ + G V L D Sbjct: 209 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSE--VFVFGDENGTVSLVD 266 Query: 173 LKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 KS SC H Q + + +SP LA+ S D + + D Sbjct: 267 TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 309 Score = 32.0 bits (71), Expect = 0.48, Method: Compositional matrix adjust. Identities = 38/175 (21%), Positives = 64/175 (36%), Gaps = 19/175 (10%) Query: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 R H + + P + LS D I+L+D S C A Sbjct: 189 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSA-----------PG 237 Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSP-VSTKHCL 158 Y ++ W+P + +F + T+ + DT + V+S ++ V + H + Sbjct: 238 YLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCV----LSSAVHSQCVTGLVFSPHSV 293 Query: 159 VAVGTRGPKVQLCDLKSGSCSHIL--QGHRQEILAVSWSPRYDYILATASADSRV 211 + + L L S S S + Q HR + +WSP +L T D +V Sbjct: 294 PFLASLSEDCSLAVLDS-SLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 31.6 bits (70), Expect = 0.57, Method: Compositional matrix adjust. Identities = 15/56 (26%), Positives = 28/56 (50%) Query: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 G++ +++ DL + H ++ V+ SP D + + S D+R+ LWD R Sbjct: 168 GSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 223 >3F3P-A nrPDB Length = 351 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 66/318 (20%), Positives = 116/318 (36%), Gaps = 77/318 (24%) Query: 23 STRRVLGLELNKD------RDVERIHGGGINTLD-IEPVEGRYMLSGGSDGVIVLYDLE- 74 S + + +L+KD D R H I +D P GR + S D + L++ + Sbjct: 31 SDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDP 90 Query: 75 ----------------NSSRQSYYTCK--------AVCSIGRDHPDVHRYSVETVQWYPH 110 N S+ S Y+ K + +G D ++E P Sbjct: 91 DQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALE-----PS 145 Query: 111 DTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQL 170 D +T +S K L + N LQ+ ++ + +S VS + + RG +L Sbjct: 146 DLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAI-IYQRGKDGKL 204 Query: 171 CDLKSGSCSHILQGHRQEILAVSWSP---RYDYILATASADSRVKLWDVRRASGCL---- 223 + L GH+ I ++SW+P R+ ++AT D R++++ + L Sbjct: 205 ------HVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEE 258 Query: 224 -------------ITLDQHNGKKSQAVESANTA-------------HNGKVNGLCFTSDG 257 + +D S E A HNG+V + + G Sbjct: 259 SLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTG 318 Query: 258 LHLLTVGTDNRMRLWNSS 275 L + G D ++RLW ++ Sbjct: 319 TILSSAGDDGKVRLWKAT 336 Score = 28.1 bits (61), Expect = 7.6, Method: Compositional matrix adjust. Identities = 33/164 (20%), Positives = 66/164 (40%), Gaps = 32/164 (19%) Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG-M 114 GR++ + SD I ++ L+ + + D H S+ + W + G + Sbjct: 23 GRHVATCSSDQHIKVFKLDKDTSNWELS---------DSWRAHDSSIVAIDWASPEYGRI 73 Query: 115 FTSSSFDKTLKVWDTNTLQTA----------DVFNFEETVYSHHMSPVSTKHCLVAVGTR 164 S+S+DKT+K+W+ + Q + + + ++YS +P L +G Sbjct: 74 IASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGND 133 Query: 165 G-----PKVQLCDLKSGSCSHILQ-------GHRQEILAVSWSP 196 G ++ DL+S + + ++ H Q +SW P Sbjct: 134 GILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCP 177 >6CHG-D nrPDB Length = 439 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 31/107 (28%), Positives = 51/107 (47%), Gaps = 13/107 (12%) Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMF 115 G Y+ G S+G I++YD++ + K + +G H H SV++V W +D Sbjct: 39 GDYLAVGCSNGAIIIYDMD--------SLKPIAMLGT-HSGAHTRSVQSVCW-SNDGRYL 88 Query: 116 TSSSFDKTLKVWD-TNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 SS D K+WD T + + F+ ++S H+ V C+V V Sbjct: 89 WSSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHV--VRWNVCIVTV 133 Score = 36.2 bits (82), Expect = 0.025, Method: Compositional matrix adjust. Identities = 23/95 (24%), Positives = 41/95 (43%), Gaps = 13/95 (13%) Query: 190 LAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVN 249 + V +SPR DY+ S +G +I D + K + + + AH V Sbjct: 31 VCVKFSPRGDYLAVGCS-------------NGAIIIYDMDSLKPIAMLGTHSGAHTRSVQ 77 Query: 250 GLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNY 284 +C+++DG +L + G D +LW+ + Y Sbjct: 78 SVCWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQQY 112 >4YCZ-A nrPDB Length = 876 Score = 36.2 bits (82), Expect = 0.027, Method: Compositional matrix adjust. Identities = 45/188 (23%), Positives = 73/188 (38%), Gaps = 39/188 (20%) Query: 53 PVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDT 112 P G + S G DG ++++ N + Q + +H+ SV V W PH+ Sbjct: 73 PKYGNILASAGYDGKVLIWRELNGAWQRIFDFA-----------LHKASVNVVSWSPHEA 121 Query: 113 G-MFTSSSFDKTLKV-------WDTNTLQTADVFNFEETVYSHHMSP---VSTKHCLVAV 161 G + +S D + V W+ + A ++ SP VS+K + Sbjct: 122 GCLLACASSDGNVSVLEFRDNSWEHSIFH-AHGLGVNSVSWAPATSPGSIVSSKPGPKST 180 Query: 162 GTR---------GPKVQLCDLKSGSCS---HILQGHRQEILAVSWSP---RYDYILATAS 206 G R K+ D + + L GH + V+WSP + YI A+AS Sbjct: 181 GNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYI-ASAS 239 Query: 207 ADSRVKLW 214 D V++W Sbjct: 240 EDRTVRIW 247 Score = 32.7 bits (73), Expect = 0.32, Method: Compositional matrix adjust. Identities = 15/37 (40%), Positives = 23/37 (62%), Gaps = 1/37 (2%) Query: 179 SHILQGHRQEILAVSWS-PRYDYILATASADSRVKLW 214 + L+GH + VSW+ P+Y ILA+A D +V +W Sbjct: 55 TETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIW 91 >3JRO-A nrPDB Length = 753 Score = 36.2 bits (82), Expect = 0.027, Method: Compositional matrix adjust. Identities = 27/101 (26%), Positives = 48/101 (47%), Gaps = 6/101 (5%) Query: 185 HRQEILAVSWSP-RYDYILATASADSRVKLWDVRR-ASGCLITLDQHN-GKKSQAVESAN 241 H + +V W+P Y +L AS+D +V + + + + I +D H G S + A Sbjct: 98 HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPAT 157 Query: 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLV 282 +G+ NG T + +T G DN +++W ++ T V Sbjct: 158 IEEDGEHNG---TKESRKFVTGGADNLVKIWKYNSDAQTYV 195 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 57/252 (22%), Positives = 95/252 (37%), Gaps = 43/252 (17%) Query: 42 HGGGINTLD-IEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRY 100 H G + +D P G + S DG ++++ EN R S AV H Sbjct: 52 HEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENG-RWSQIAVHAV----------HSA 100 Query: 101 SVETVQWYPHDTG-MFTSSSFDKTLKV--WDTNTLQTADVFNFEET-VYSHHMSPVSTKH 156 SV +VQW PH+ G + +S D + V + N + + + V S +P + + Sbjct: 101 SVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEE 160 Query: 157 CLVAVGTRGPK----------VQLCDLKSGSCSHI----LQGHRQEILAVSWSPR--YDY 200 GT+ + V++ S + +++ L+GH + V+WSP Sbjct: 161 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRS 220 Query: 201 ILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHL 260 LA+ S D +W G K + A+ + +G V L Sbjct: 221 YLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALS-------- 272 Query: 261 LTVGTDNRMRLW 272 G DN++ LW Sbjct: 273 ---GGDNKVTLW 281 >3JRP-A nrPDB Length = 379 Score = 36.2 bits (82), Expect = 0.028, Method: Compositional matrix adjust. Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 8/121 (6%) Query: 167 KVQLCDLKSGSCSHIL--QGHRQEILAVSWSP-RYDYILATASADSRVKLWDVRR-ASGC 222 KV + ++G S I H + +V W+P Y +L AS+D +V + + + + Sbjct: 80 KVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTS 139 Query: 223 LITLDQHN-GKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTL 281 I +D H G S + A +G+ NG T + +T G DN +++W ++ T Sbjct: 140 PIIIDAHAIGVNSASWAPATIEEDGEHNG---TKESRKFVTGGADNLVKIWKYNSDAQTY 196 Query: 282 V 282 V Sbjct: 197 V 197 Score = 30.8 bits (68), Expect = 0.96, Method: Compositional matrix adjust. Identities = 57/252 (22%), Positives = 95/252 (37%), Gaps = 43/252 (17%) Query: 42 HGGGINTLD-IEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRY 100 H G + +D P G + S DG ++++ EN R S AV H Sbjct: 54 HEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENG-RWSQIAVHAV----------HSA 102 Query: 101 SVETVQWYPHDTG-MFTSSSFDKTLKV--WDTNTLQTADVFNFEET-VYSHHMSPVSTKH 156 SV +VQW PH+ G + +S D + V + N + + + V S +P + + Sbjct: 103 SVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEE 162 Query: 157 CLVAVGTRGPK----------VQLCDLKSGSCSHI----LQGHRQEILAVSWSPR--YDY 200 GT+ + V++ S + +++ L+GH + V+WSP Sbjct: 163 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRS 222 Query: 201 ILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHL 260 LA+ S D +W G K + A+ + +G V L Sbjct: 223 YLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALS-------- 274 Query: 261 LTVGTDNRMRLW 272 G DN++ LW Sbjct: 275 ---GGDNKVTLW 283 >5WLC-LU nrPDB Length = 489 Score = 36.2 bits (82), Expect = 0.029, Method: Compositional matrix adjust. Identities = 42/175 (24%), Positives = 68/175 (38%), Gaps = 21/175 (12%) Query: 43 GGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSV 102 I +L E + S GSD IVLYDL +S T K V ++ Sbjct: 219 ADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSP----TQKIVQTM----------RT 264 Query: 103 ETVQWYPHDTGMFTSSSFDKTLKVWDTNTL-QTADVF-NFEETVYSHHMSPVSTKHCLVA 160 + W P + F +++ D +D L ++ +VF + V SP + + Sbjct: 265 NAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDE---IV 321 Query: 161 VGTRGPKVQLCDLKSGSCSHILQGHR-QEILAVSWSPRYDYILATASADSRVKLW 214 G+ +++ G I R Q + V +S YI++ S D V+LW Sbjct: 322 TGSYDKSIRIYKTNHGHSREIYHTKRMQHVFQVKYSMDSKYIIS-GSDDGNVRLW 375 Score = 29.3 bits (64), Expect = 3.5, Method: Compositional matrix adjust. Identities = 39/188 (20%), Positives = 76/188 (40%), Gaps = 26/188 (13%) Query: 124 LKVWDTNTLQ-TADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSH-I 181 + +WD N L+ +D+ + + S + T L + G+ V L DL++ S + I Sbjct: 201 IHLWDVNRLKPVSDLSWGADNITSLKFNQNETD-ILASTGSDNSIV-LYDLRTNSPTQKI 258 Query: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESAN 241 +Q R A+ W+P + TA+ D +D+R S L Sbjct: 259 VQTMRTN--AICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFKD------------- 303 Query: 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSC 301 H V + F+ G ++T D +R++ +++G + + + K + F V Sbjct: 304 --HVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQHV-----FQVKY 356 Query: 302 GCSSEFVF 309 S+++ Sbjct: 357 SMDSKYII 364 Score = 28.9 bits (63), Expect = 3.8, Method: Compositional matrix adjust. Identities = 67/330 (20%), Positives = 124/330 (37%), Gaps = 52/330 (15%) Query: 59 MLSGGSDGVIVLYDLENSSRQSYYTCKA----VCSIGRDHPDVHRYSVETVQWYPHDTGM 114 + +G +DGVI +++ S+R+ + + KA V + P H + Sbjct: 83 LATGSADGVIKYWNM--STREEFVSFKAHYGLVTGLCVTQPRFHDKKPDL-----KSQNF 135 Query: 115 FTSSSFDKTLKVW--------DTNTLQTADVFNFEETVYSHH----MSPVSTKHCLVAVG 162 S S DKT+K+W + N+ V N E + + + + Sbjct: 136 MLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQGIDSHRENSTFA 195 Query: 163 TRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGC 222 T G K+ L D+ L I ++ ++ ILA+ +D+ + L+D+R Sbjct: 196 TGGAKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRT---- 251 Query: 223 LITLDQHNGKKSQAVESANTAHNGKVNGLCFTS-DGLHLLTVGTDNRMRLWNSSNGENTL 281 N + V++ T N +C+ + + +T D+ ++ N +L Sbjct: 252 -------NSPTQKIVQTMRT------NAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSL 298 Query: 282 VNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCV 341 N K ++ + F+ E V Y +I +Y G + H K + V Sbjct: 299 -NVFKDHVSAVMDVDFS---PTGDEIVTGSYDKSIRIYKTNHGHSREIY--HTKRMQ-HV 351 Query: 342 FQSNF----QELYSGSRDCNILAWVPSLYE 367 FQ + + + SGS D N+ W +E Sbjct: 352 FQVKYSMDSKYIISGSDDGNVRLWRSKAWE 381 >4BZK-B nrPDB Length = 297 Score = 35.4 bits (80), Expect = 0.041, Method: Compositional matrix adjust. Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 8/121 (6%) Query: 167 KVQLCDLKSGSCSHIL--QGHRQEILAVSWSP-RYDYILATASADSRVKLWDVRR-ASGC 222 KV + ++G S I H + +V W+P Y +L AS+D +V + + + + Sbjct: 78 KVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTS 137 Query: 223 LITLDQHN-GKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTL 281 I +D H G S + A +G+ NG T + +T G DN +++W ++ T Sbjct: 138 PIIIDAHAIGVNSASWAPATIEEDGEHNG---TKESRKFVTGGADNLVKIWKYNSDAQTY 194 Query: 282 V 282 V Sbjct: 195 V 195 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 59/263 (22%), Positives = 98/263 (37%), Gaps = 43/263 (16%) Query: 31 ELNKDRDVERIHGGGINTLD-IEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCS 89 E +K D H G + +D P G + S DG ++++ EN R S AV Sbjct: 41 ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENG-RWSQIAVHAV-- 97 Query: 90 IGRDHPDVHRYSVETVQWYPHDTG---MFTSSSFDKTLKVWDTNTLQTADVFNFEET-VY 145 H SV +VQW PH+ G + SS ++ + N + + + V Sbjct: 98 --------HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVN 149 Query: 146 SHHMSPVSTKHCLVAVGTRGPK----------VQLCDLKSGSCSHI----LQGHRQEILA 191 S +P + + GT+ + V++ S + +++ L+GH + Sbjct: 150 SASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRD 209 Query: 192 VSWSPR--YDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVN 249 V+WSP LA+ S D +W G K + A+ + +G V Sbjct: 210 VAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVL 269 Query: 250 GLCFTSDGLHLLTVGTDNRMRLW 272 L G DN++ LW Sbjct: 270 ALS-----------GGDNKVTLW 281 >6BX3-B nrPDB Length = 412 Score = 35.4 bits (80), Expect = 0.046, Method: Compositional matrix adjust. Identities = 45/229 (19%), Positives = 94/229 (41%), Gaps = 16/229 (6%) Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMF 115 G Y+ G ++G +V+YD++ T + +C G + H + ++ W P D + Sbjct: 37 GDYLALGCANGALVIYDMD--------TFRPICVPG-NMLGAHVRPITSIAWSP-DGRLL 86 Query: 116 TSSSFDKTLKVWD-TNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLK 174 +SS D ++K+WD + + F+ ++ + C VA + D Sbjct: 87 LTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLC-VATIFEESDAYVIDFS 145 Query: 175 SGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKS 234 + + +L ++ L S +P + Y+L + V + G L H+ ++ Sbjct: 146 NDPVASLLSKSDEKQL--SSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQT 203 Query: 235 QAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN-SSNGENTLV 282 + + S + + L + +G L +D +R + S + EN+ V Sbjct: 204 ECIHSLKIT-SSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAV 251 >4U1E-I nrPDB Length = 347 Score = 35.0 bits (79), Expect = 0.058, Method: Compositional matrix adjust. Identities = 37/136 (27%), Positives = 58/136 (42%), Gaps = 20/136 (14%) Query: 4 FLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIH------GGGINTLDIEPVEGR 57 FL+ +++P + E R EL K + E IH G T+ +G+ Sbjct: 108 FLAILDNVMKNPGSINIYEIERDSATHELTKVSE-EPIHKIITHEGLDAATVAGWSTKGK 166 Query: 58 YMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTS 117 Y+++G DG I YD+ N+ D D+H S+ +Q+ P D F + Sbjct: 167 YIIAGHKDGKISKYDVSNNYEYV------------DSIDLHEKSISDMQFSP-DLTYFIT 213 Query: 118 SSFDKTLKVWDTNTLQ 133 SS D + D +TLQ Sbjct: 214 SSRDTNSFLVDVSTLQ 229 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 17/44 (38%), Positives = 25/44 (56%), Gaps = 3/44 (6%) Query: 35 DRDVERIHG--GGINTLDIEPVEGRYMLSGGSDGVIVLYDLENS 76 + ++ R+ G G +NT+ I P +G SGG DG I L+ E S Sbjct: 283 EEEIGRVQGHFGPLNTVAISP-QGTSYASGGEDGFIRLHHFEKS 325 Score = 27.7 bits (60), Expect = 9.3, Method: Compositional matrix adjust. Identities = 28/97 (28%), Positives = 43/97 (44%), Gaps = 17/97 (17%) Query: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESAN 241 L GH + + V ++ D +L + S DS +W L TLD H G Sbjct: 6 LTGHERPLTQVKYNKEGD-LLFSCSKDSSASVWYSLNGER-LGTLDGHTG---------- 53 Query: 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 T + V+ CFT + +T D ++LW+ SNG+ Sbjct: 54 TIWSIDVD--CFTK---YCVTGSADYSIKLWDVSNGQ 85 >4OWR-A nrPDB Length = 339 Score = 34.7 bits (78), Expect = 0.073, Method: Compositional matrix adjust. Identities = 54/228 (23%), Positives = 85/228 (37%), Gaps = 32/228 (14%) Query: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWY--PHDT 112 +G + + D ++DL SS Q+ + H V+T+ W P+ + Sbjct: 68 DGSKVFTASCDKTAKMWDL--SSNQAIQIAQ------------HDAPVKTIHWIKAPNYS 113 Query: 113 GMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCD 172 + T S +DKTLK WDT + V E Y + V +VA RG V + Sbjct: 114 CVMTGS-WDKTLKFWDTRSSNPMMVLQLPERCYC---ADVIYPMAVVATAERGLIVYQLE 169 Query: 173 LKSGSCSHILQ--GHRQEILAVSWSPRYDYI-LATASADSRVKLWDVRRASGCL--ITLD 227 + I H+ +A+ + A S + RV + + + T Sbjct: 170 NQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFK 229 Query: 228 QH--NGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 H NG + A + VNG+ F L TVG+D R W+ Sbjct: 230 CHRSNGTNTSAPQDIYA-----VNGIAFHPVHGTLATVGSDGRFSFWD 272 Score = 32.3 bits (72), Expect = 0.42, Method: Compositional matrix adjust. Identities = 12/44 (27%), Positives = 22/44 (50%) Query: 235 QAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 Q + A H G V +C++ DG + T D ++W+ S+ + Sbjct: 47 QTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQ 90 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 23/87 (26%), Positives = 39/87 (44%), Gaps = 2/87 (2%) Query: 97 VHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKH 156 +H V V W + +FT+S DKT K+WD ++ Q + + V + H Sbjct: 55 MHTGPVLDVCWSDDGSKVFTASC-DKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYS 113 Query: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQ 183 C V G+ ++ D +S + +LQ Sbjct: 114 C-VMTGSWDKTLKFWDTRSSNPMMVLQ 139 >4L9O-A nrPDB Length = 349 Score = 34.7 bits (78), Expect = 0.080, Method: Compositional matrix adjust. Identities = 48/237 (20%), Positives = 91/237 (38%), Gaps = 37/237 (15%) Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQW-YPHDTGM 114 GR + + SD I +++++ +++ T IG + P V V W +P + Sbjct: 81 GRRLATCSSDKTIKIFEIDGENQRLVETL-----IGHEGP------VWQVAWAHPKFGVI 129 Query: 115 FTSSSFDKTLKVWDTNT---LQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLC 171 S S+D + +W + + A+ + +V S +P L+ + G K+ + Sbjct: 130 LASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDG-KISIV 188 Query: 172 DLKSGSCSH--ILQGHRQEILAVSWS----PRYDYILATASADSRVKLWDVRRASGCLIT 225 + K G ++QGH + A SW+ P + D+ VK+W A+ I Sbjct: 189 EFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIE 248 Query: 226 LDQHNGKKSQAVESANTAHNGKVNGLCFTSDGL---HLLTVGTDNRMRLWNSSNGEN 279 E A H+ V + ++ L ++ T D + +W N Sbjct: 249 ------------EEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSN 293 >5OV3-A nrPDB Length = 381 Score = 34.3 bits (77), Expect = 0.10, Method: Compositional matrix adjust. Identities = 20/82 (24%), Positives = 36/82 (43%), Gaps = 16/82 (19%) Query: 197 RYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD 256 R+ +LA D R+ +WD ++ + +AH V LC++ D Sbjct: 35 RWGTLLAVGCNDGRIVIWDFL----------------TRGIAKIISAHIHPVCSLCWSRD 78 Query: 257 GLHLLTVGTDNRMRLWNSSNGE 278 G L++ TDN + W+ +G+ Sbjct: 79 GHKLVSASTDNIVSQWDVLSGD 100 Score = 32.7 bits (73), Expect = 0.28, Method: Compositional matrix adjust. Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 1/59 (1%) Query: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 L+AVG ++ + D + + I+ H + ++ WS R + L +AS D+ V WDV Sbjct: 39 LLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWS-RDGHKLVSASTDNIVSQWDV 96 >5N4A-A nrPDB Length = 771 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 50/218 (22%), Positives = 85/218 (38%), Gaps = 40/218 (18%) Query: 90 IGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHM 149 + + +VH V W + +FT S D+T+ W+ V + H Sbjct: 5 VKQSSANVHSELTAAVGWNVWNE-LFTCSD-DQTIHKWNMLGEPEQKVSTLDAYFTDMHW 62 Query: 150 SPVSTKHC------LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYD-YIL 202 PVS+K + AV V++ ++G ++GH+ +++ WS YD L Sbjct: 63 YPVSSKKTQAGGTDVFAVACTDGSVKILS-RTGRVEKSIEGHKGACISLRWS--YDGTAL 119 Query: 203 ATASADSRVKLWDVRRASGCLITLDQHNGK--------------------------KSQA 236 ATA D VK+W R TL Q + S A Sbjct: 120 ATAGEDGSVKIWS--RNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIKSLSSNA 177 Query: 237 VESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 ++A AH+G V + ++ ++T G D + ++W+S Sbjct: 178 KQNAWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWDS 215 Score = 28.1 bits (61), Expect = 7.3, Method: Compositional matrix adjust. Identities = 28/127 (22%), Positives = 46/127 (36%), Gaps = 11/127 (8%) Query: 237 VESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNG--ENTLVNYGKVCNNSKKG 294 VE + H G L ++ DG L T G D +++W S NG +TL + Sbjct: 96 VEKSIEGHKGACISLRWSYDGTALATAGEDGSVKIW-SRNGMLRSTLAQADSPVYSIVWA 154 Query: 295 LKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSR 354 C C+ V + S+ A + +LK + ++ + +G Sbjct: 155 YDCDQLCYCTGSNVVIKSLSSNAKQNAWKAHDGVVLKVDWSPINHLII--------TGGE 206 Query: 355 DCNILAW 361 DC W Sbjct: 207 DCKYKVW 213 >3JZG-A nrPDB Length = 402 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 49/231 (21%), Positives = 93/231 (40%), Gaps = 39/231 (16%) Query: 153 STKHCLVAV-GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRV 211 +T H L+AV G+RG +++ + + C GH I + + PR +L + S D + Sbjct: 118 NTSHPLLAVAGSRG-IIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHAL 176 Query: 212 KLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL 271 +LW+++ + L+ A+ H +V + G +++ G D+ ++L Sbjct: 177 RLWNIQ--TDTLV-----------AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKL 223 Query: 272 WNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLK 331 W +N ++ N K+ + + P+ S + +S I Sbjct: 224 WR--------INSKRMMNAIKESYDY------NPNKTNRPFISQKIHFPDFSTRDI---- 265 Query: 332 GHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLN 382 H VDC + + + S S + I+ W P E DD + S+ N Sbjct: 266 -HRNYVDCVRWLGDL--ILSKSCENAIVCWKPGKME---DDIDKIKPSESN 310 >4J0W-A nrPDB Length = 343 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 11/35 (31%), Positives = 22/35 (62%) Query: 327 ITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 I +L+GH ++ C V + ++S ++DC+I+ W Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKW 41 Score = 31.6 bits (70), Expect = 0.70, Method: Compositional matrix adjust. Identities = 32/136 (23%), Positives = 55/136 (40%), Gaps = 11/136 (8%) Query: 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSC 301 T H V+GL F L + D +++WN + EN+ V ++ L Sbjct: 106 TGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVA--ENSYVETLFGHQDAVAALD----- 158 Query: 302 GCSSEFVFVPYG--STIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNIL 359 S E G T+ V+ + Q+ + GH ++D C+ N + + SG+ D ++ Sbjct: 159 ALSRECCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSID-CIHLINEEHMVSGADDGSVA 216 Query: 360 AWVPSLYEPVPDDDET 375 W S P+ E Sbjct: 217 LWGLSKKRPLALQREA 232 Score = 28.5 bits (62), Expect = 4.7, Method: Compositional matrix adjust. Identities = 26/125 (20%), Positives = 45/125 (36%), Gaps = 6/125 (4%) Query: 243 AHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE--NTLVNYGKVCNNSKKGLKFTVS 300 H + L T D + + D + W+ +G + + K G V Sbjct: 12 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 71 Query: 301 C-GCSSEFVFVPYG---STIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDC 356 C SS+ ++ G I ++ S + + GH V F+ +LYS S D Sbjct: 72 CMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDR 131 Query: 357 NILAW 361 ++ W Sbjct: 132 SVKVW 136 >5OQL-d nrPDB Length = 446 Score = 33.1 bits (74), Expect = 0.21, Method: Compositional matrix adjust. Identities = 25/72 (34%), Positives = 36/72 (50%), Gaps = 17/72 (23%) Query: 202 LATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLL 261 +A+ S D VK+WD L T D+ + + AHN V GL FT+D LL Sbjct: 82 IASGSGDGVVKVWD-------LTTRDEETWRVA--------AHNNIVKGLTFTNDK-KLL 125 Query: 262 TVGTDNRMRLWN 273 + TD ++LW+ Sbjct: 126 SCATDG-IKLWD 136 Score = 32.3 bits (72), Expect = 0.37, Method: Compositional matrix adjust. Identities = 58/246 (23%), Positives = 107/246 (43%), Gaps = 41/246 (16%) Query: 43 GGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSR-QSYYTCKAVCSIGRDHPDVHRYS 101 GG +L + S G G I ++DLE+S+ Q+ V +I DV Sbjct: 153 GGPYTSLSFHRSANTFAASSGQ-GCIRIWDLEHSTAGQAIQWPSFVDTI----TDVCFNQ 207 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNT----LQTADVFNFEETVYSHHMSPVSTKHC 157 VET + S + D+++ ++D T ++T F V++ P+ + Sbjct: 208 VET--------SVIGSVATDRSIILFDLRTNMPVIKTVLHFACNRIVFN----PMEAMN- 254 Query: 158 LVAVGTRGPKVQLCDLKS-GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 +AV + + + D ++ +I +GH ++ V +SP + L + S D ++LW Sbjct: 255 -LAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEE-LVSGSYDRTIRLW-- 310 Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN 276 RR +G + D ++ K+ Q +V +T D ++LT D +RLW ++ Sbjct: 311 RRDAGH--SRDVYHTKRMQ-----------RVFRTMWTMDSKYILTGSDDGNVRLWRANA 357 Query: 277 GENTLV 282 E + V Sbjct: 358 SERSGV 363 >3ODT-A nrPDB Length = 313 Score = 32.7 bits (73), Expect = 0.27, Method: Compositional matrix adjust. Identities = 26/123 (21%), Positives = 49/123 (39%), Gaps = 6/123 (4%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHC 157 H SV + F ++S DKT+K+W + + F+ H++ V H Sbjct: 141 HNASVWDAKVVSFSENKFLTASADKTIKLWQND--KVIKTFSGIHNDVVRHLAVVDDGH- 197 Query: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 ++ G ++L D+ +G +GH + + P D + + D V++W Sbjct: 198 FISCSNDGL-IKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD--IVSCGEDRTVRIWSKE 254 Query: 218 RAS 220 S Sbjct: 255 NGS 257 >4XFV-A nrPDB Length = 792 Score = 32.0 bits (71), Expect = 0.45, Method: Compositional matrix adjust. Identities = 51/225 (22%), Positives = 93/225 (41%), Gaps = 19/225 (8%) Query: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGM 114 E +Y+L+ G V V S C+ V + H D + Q P D + Sbjct: 167 EKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAEL-EGHEDWVKSLAFRHQETPGDY-L 224 Query: 115 FTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCD-L 173 S S D+ +++W ++ D+ + E S ++ +S K K Q+ D L Sbjct: 225 LCSGSQDRYIRLW---RIRINDLIDDSEE-DSKKLTLLSNKQY---------KFQIDDEL 271 Query: 174 KSG-SCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGK 232 + G + ++ GH I ++ W +LA A+AD+ + +W+ SG + + Sbjct: 272 RVGINFEALIMGHDDWISSLQWHESRLQLLA-ATADTSLMVWEPDETSGIWVCSLRLGEM 330 Query: 233 KSQAVESANTAHNGKVNGLCFTSDGL-HLLTVGTDNRMRLWNSSN 276 S+ +A + G + L FT + + LT G R+W + + Sbjct: 331 SSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKD 375 Score = 29.3 bits (64), Expect = 3.0, Method: Compositional matrix adjust. Identities = 43/208 (20%), Positives = 72/208 (34%), Gaps = 34/208 (16%) Query: 121 DKTLKVWDTNTLQTADVFNFEETVYSHHMSP-------VSTKHCLVAVGTRGPKV----- 168 D T+ +W N E T+ P V K L+A+G V Sbjct: 127 DGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASF 186 Query: 169 QLCDLKSGSCSHI--LQGHRQEILAVSWSPRY---DYILATASADSRVKLWDVR------ 217 L D C + L+GH + ++++ + DY+L + S D ++LW +R Sbjct: 187 ILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLID 246 Query: 218 --RASGCLITLDQHNGKKSQA---------VESANTAHNGKVNGLCFTSDGLHLLTVGTD 266 +TL + K Q E+ H+ ++ L + L LL D Sbjct: 247 DSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATAD 306 Query: 267 NRMRLWNSSNGENTLVNYGKVCNNSKKG 294 + +W V ++ S KG Sbjct: 307 TSLMVWEPDETSGIWVCSLRLGEMSSKG 334 Score = 29.3 bits (64), Expect = 3.5, Method: Compositional matrix adjust. Identities = 14/45 (31%), Positives = 23/45 (51%) Query: 237 VESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTL 281 ++ A H+ + L F+ DG LL+V D + LW + +NT Sbjct: 602 IKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTF 646 Score = 28.1 bits (61), Expect = 7.6, Method: Compositional matrix adjust. Identities = 26/94 (27%), Positives = 39/94 (41%), Gaps = 9/94 (9%) Query: 98 HRYSVETVQWYPHDTG-MFTSSSFDKTLKVW-------DTNTLQTADVFNFEETVYSHHM 149 H + W P + G +F ++S DKT+KVW D L+ + T S H Sbjct: 656 HTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHD 715 Query: 150 SPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQ 183 S + K L++VG ++ L G I Q Sbjct: 716 SMIREK-ILISVGLENGEIYLYSYTLGKFELITQ 748 >5OQL-X nrPDB Length = 630 Score = 32.0 bits (71), Expect = 0.50, Method: Compositional matrix adjust. Identities = 27/115 (23%), Positives = 52/115 (45%), Gaps = 26/115 (22%) Query: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGM 114 +G+++++GG+D +V+Y+ + +T HR +V + + T Sbjct: 257 DGKFVVTGGADKRLVVYNAADLKPIKAFT-------------QHRDAVTGLA-FRRGTNQ 302 Query: 115 FTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHH-----MSPVSTKHCLVAVGTR 164 S S D+T+KVW + D + ET++ H + + + C V+VG R Sbjct: 303 LYSCSKDRTVKVW------SLDELAYVETLFGHQDEILDIDALGQERC-VSVGAR 350 >6E29-D nrPDB Length = 345 Score = 31.6 bits (70), Expect = 0.56, Method: Compositional matrix adjust. Identities = 25/81 (30%), Positives = 42/81 (51%), Gaps = 3/81 (3%) Query: 139 NFEETVYSHHMSPV--STKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSP 196 N T+ S H + V + K +A G V + DL++ + L+GH + I ++SWS Sbjct: 18 NITNTIRSGHSTCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSR 77 Query: 197 RYDYILATASADSRVKLWDVR 217 Y+L +A +V LWD++ Sbjct: 78 CGRYLL-SACQGWKVILWDLQ 97 Score = 29.6 bits (65), Expect = 2.6, Method: Compositional matrix adjust. Identities = 19/92 (20%), Positives = 40/92 (43%), Gaps = 3/92 (3%) Query: 128 DTNTLQTADVFNFEETVYS---HHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQG 184 D +T+Q F++ V +H++ +T + A ++ + + GS +L+G Sbjct: 253 DPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERGHGSLVRMLEG 312 Query: 185 HRQEILAVSWSPRYDYILATASADSRVKLWDV 216 ++E + W P + A R+ +W V Sbjct: 313 PKEEQGVIEWHPHRALLAACGLETGRINIWSV 344 >5WLC-SG nrPDB Length = 573 Score = 31.6 bits (70), Expect = 0.59, Method: Compositional matrix adjust. Identities = 26/147 (17%), Positives = 64/147 (43%), Gaps = 11/147 (7%) Query: 238 ESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKF 297 E+ H ++ + + DG +++T G D ++ +W++ +L + ++G Sbjct: 229 ENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTE----SLSPVKVIPTKDRRGEVL 284 Query: 298 TVSCGCSSEFVFVPYGS-TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDC 356 +++ +S+ ++ I Y++ Q+ +L GH+ V+ + + + G+RD Sbjct: 285 SLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDR 344 Query: 357 NILAWVPSLYEPVPDDDETTTKSQLNP 383 + W +PD+ T + P Sbjct: 345 TAMLW------KIPDETRLTFRGGDEP 365 >4J0X-A nrPDB Length = 451 Score = 31.6 bits (70), Expect = 0.64, Method: Compositional matrix adjust. Identities = 26/147 (17%), Positives = 64/147 (43%), Gaps = 11/147 (7%) Query: 238 ESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKF 297 E+ H ++ + + DG +++T G D ++ +W++ +L + ++G Sbjct: 107 ENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWST----ESLSPVKVIPTKDRRGEVL 162 Query: 298 TVSCGCSSEFVFVPYGS-TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDC 356 +++ +S+ ++ I Y++ Q+ +L GH+ V+ + + + G+RD Sbjct: 163 SLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDR 222 Query: 357 NILAWVPSLYEPVPDDDETTTKSQLNP 383 + W +PD+ T + P Sbjct: 223 TAMLW------KIPDETRLTFRGGDEP 243 >4G56-B nrPDB Length = 357 Score = 31.6 bits (70), Expect = 0.65, Method: Compositional matrix adjust. Identities = 16/57 (28%), Positives = 25/57 (43%) Query: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRR 218 G + V++ DL + H E+ V+ P D I + D R+ LWD R+ Sbjct: 157 GGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRK 213 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 43/180 (23%), Positives = 65/180 (36%), Gaps = 33/180 (18%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H +N + P + LS G DG I+L+D + A +I Sbjct: 180 HSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPT--------- 230 Query: 102 VETVQWYPHDTGMFTSSSFDKT-----LKVWDTNTLQTADVF--NFEETVYSHHMSPV-- 152 +V W+P F D+T + + + ++ QT+ V N YS+H SP Sbjct: 231 --SVTWHPEKDDTFACG--DETGNVSLVNIKNPDSAQTSAVHSQNITGLAYSYHSSPFLA 286 Query: 153 -STKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRV 211 ++ C VAV DL HR + V+WSP T D +V Sbjct: 287 SISEDCTVAVLDADFSEVFRDLS----------HRDFVTGVAWSPLDHSKFTTVGWDHKV 336 >4HR3-A nrPDB Length = 415 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 13/45 (28%), Positives = 21/45 (46%) Query: 84 CKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWD 128 CK + +G P+ HRY+ ++ P DT T T+ +D Sbjct: 189 CKVIIFMGLTDPNAHRYARHSMVLVPMDTPGITVERMLPTMGFYD 233 >5YZG-2 nrPDB Length = 646 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 29/112 (25%), Positives = 47/112 (41%), Gaps = 20/112 (17%) Query: 167 KVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITL 226 +V L +L S S HR I V + + D+I+ TAS D VK W Sbjct: 71 RVYLDNLPSASMYERSYMHRDVITHVVCT-KTDFII-TASHDGHVKFWK----------- 117 Query: 227 DQHNGKKSQAVESAN--TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN 276 K + +E +H G + + +S+G +VG D M++++ N Sbjct: 118 -----KIEEGIEFVKHFRSHLGVIESIAVSSEGALFCSVGDDKAMKVFDVVN 164 Score = 29.3 bits (64), Expect = 3.1, Method: Compositional matrix adjust. Identities = 9/28 (32%), Positives = 19/28 (67%) Query: 251 LCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 +CF+ DG + T+G+D ++R++ G+ Sbjct: 286 VCFSPDGKKIATIGSDRKVRIFRFVTGK 313 >5V7Q-R nrPDB Length = 104 Score = 30.4 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 11/27 (40%), Positives = 19/27 (70%) Query: 163 TRGPKVQLCDLKSGSCSHILQGHRQEI 189 T+GPK+++ K+ + H QGHRQ++ Sbjct: 69 TKGPKIRIHKFKNKTGYHKRQGHRQQL 95 >5O60-S nrPDB Length = 103 Score = 30.4 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 11/27 (40%), Positives = 19/27 (70%) Query: 163 TRGPKVQLCDLKSGSCSHILQGHRQEI 189 T+GPK+++ K+ + H QGHRQ++ Sbjct: 68 TKGPKIRIHKFKNKTGYHKRQGHRQQL 94 >6BX3-A nrPDB Length = 314 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 30/116 (25%), Positives = 46/116 (39%), Gaps = 19/116 (16%) Query: 163 TRGPKVQLCDLKSGSCSHIL-QGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASG 221 T+G + + D+ + S L H + + WSP I ATAS D V++ + + G Sbjct: 30 TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCI-ATASDDFSVEI--IHLSYG 86 Query: 222 CLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNG 277 L T H V L F G L T D +++W++ NG Sbjct: 87 LLHTF---------------IGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG 127 >5A9Q-0 nrPDB Length = 380 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 14/51 (27%), Positives = 24/51 (47%) Query: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGK 232 L G R + V P +++AT D + +WDVR+ + + L H + Sbjct: 213 LTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAE 263 >4IP7-A nrPDB Length = 543 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 14/45 (31%), Positives = 25/45 (55%) Query: 137 VFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHI 181 + N E V S SP+S + +A+ T+GP+++ L+ G S + Sbjct: 100 IANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEV 144 >5WLC-LW nrPDB Length = 554 Score = 30.0 bits (66), Expect = 2.0, Method: Compositional matrix adjust. Identities = 24/141 (17%), Positives = 56/141 (39%), Gaps = 18/141 (12%) Query: 136 DVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 195 ++ ++ + + H+ + + LV G G ++ D+ +G L+ +A++ + Sbjct: 183 ELHRLKQHIEARHLDFLPYHYLLVTAGETG-WLKYHDVSTGQLVSELRTKAGPTMAMAQN 241 Query: 196 PRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS 255 P ++ ++ ++ V LW + L + G VN + Sbjct: 242 P-WNAVMHLGHSNGTVSLWSPSMPEPLVKLL----------------SARGPVNSIAIDR 284 Query: 256 DGLHLLTVGTDNRMRLWNSSN 276 G ++ T G D M++W+ N Sbjct: 285 SGYYMATTGADRSMKIWDIRN 305 >5K0Y-T nrPDB Length = 329 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 26/98 (26%), Positives = 40/98 (40%), Gaps = 17/98 (17%) Query: 181 ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA 240 +LQGH + I + ++ D +L T + D V +W NG++ Sbjct: 5 LLQGHERSITQIKYNREGD-LLFTVAKDPIVNVWY------------SVNGERL----GT 47 Query: 241 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 H G V + D H+LT DN RLW+ G+ Sbjct: 48 YMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGK 85 >2P9P-C nrPDB Length = 372 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 41/186 (22%), Positives = 72/186 (38%), Gaps = 20/186 (10%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ------TADVFNFEETVYSHHMSP 151 H V V W P D+ + D+ VW TL+ T + +P Sbjct: 51 HNGQVTGVDWAP-DSNRIVTCGTDRNAYVW---TLKGRTWKPTLVILRINRAARCVRWAP 106 Query: 152 VSTKHCLVAVGTRGPKVQLCDLKSGS----CSHILQGHRQEILAVSWSPRYDYILATASA 207 K AVG+ + +C + + C HI + R +L++ W P +LA S Sbjct: 107 NEKK---FAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPN-SVLLAAGSC 162 Query: 208 DSRVKLWDVRRASGCLITLDQHNGKKSQAVESA--NTAHNGKVNGLCFTSDGLHLLTVGT 265 D + +++ G K E +++ G V+G+CF+++G + V Sbjct: 163 DFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSH 222 Query: 266 DNRMRL 271 D+ + L Sbjct: 223 DSTVCL 228 Score = 28.1 bits (61), Expect = 6.7, Method: Compositional matrix adjust. Identities = 11/29 (37%), Positives = 17/29 (58%) Query: 244 HNGKVNGLCFTSDGLHLLTVGTDNRMRLW 272 HNG+V G+ + D ++T GTD +W Sbjct: 51 HNGQVTGVDWAPDSNRIVTCGTDRNAYVW 79 >6CHG-A nrPDB Length = 312 Score = 29.6 bits (65), Expect = 2.3, Method: Compositional matrix adjust. Identities = 25/106 (23%), Positives = 50/106 (47%), Gaps = 14/106 (13%) Query: 175 SGSCSHILQGHRQEILAVSWSPRYDY-ILATASADSRVKLWDVRRASGCLITLDQHNGKK 233 SG+ + H ++++ P++D IL++ S D ++++D + CL TL Sbjct: 126 SGTALKTMSAHSDAVVSID-IPKFDSSILSSGSYDGLIRIFDTE-SGHCLKTL------- 176 Query: 234 SQAVESANTAHNG--KVNGLCFTSDGLHLLTVGTDNRMRLWNSSNG 277 + A +G ++ + F+ +G LL DN ++LW + G Sbjct: 177 --TYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRG 220 >1PI6-A nrPDB Length = 615 Score = 29.6 bits (65), Expect = 2.3, Method: Compositional matrix adjust. Identities = 43/174 (24%), Positives = 70/174 (40%), Gaps = 26/174 (14%) Query: 138 FNFEETVYSHH----------MSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQ 187 F F + +HH SP S + + R K+ D KSG ++ ++ Sbjct: 193 FKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDR--KISCFDGKSGEFLKYIEDDQE 250 Query: 188 E----ILAVSWSPRYDYILATASADSRVKLWDVRRASGCL--ITLDQHNGKKSQAVESAN 241 I A+SW + AT AD+ +++WDV S C+ TLD+ Q A Sbjct: 251 PVQGGIFALSWLDSQKF--ATVGADATIRVWDV-TTSKCVQKWTLDKQQLGNQQVGVVA- 306 Query: 242 TAHNGKVNGLCFTSDG-LHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKG 294 NG++ L DG L+ +G D ++ + N T + + + S G Sbjct: 307 -TGNGRIISLSL--DGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDG 357 >3ACP-A nrPDB Length = 417 Score = 29.6 bits (65), Expect = 2.5, Method: Compositional matrix adjust. Identities = 31/132 (23%), Positives = 55/132 (41%), Gaps = 20/132 (15%) Query: 16 LRLRR-----AESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVL 70 L++RR E +VL N R++++ H I L P G ++S D + + Sbjct: 104 LQMRRFILGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFP-SGEALISSSQDMQLKI 162 Query: 71 YDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN 130 + +++ S IG HR +V + + S+S D T+++W+ Sbjct: 163 WSVKDGSNPRTL-------IG------HRATVTDIAIIDRGRNVL-SASLDGTIRLWECG 208 Query: 131 TLQTADVFNFEE 142 T T FN +E Sbjct: 209 TGTTIHTFNRKE 220 >6GC1-A nrPDB Length = 579 Score = 29.3 bits (64), Expect = 3.0, Method: Compositional matrix adjust. Identities = 29/133 (21%), Positives = 49/133 (36%), Gaps = 26/133 (19%) Query: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQGHR--------------------QEILAVSWSP 196 CL + V+ LK G+ H++ G R Q L V+W Sbjct: 432 CLFVADSESSTVRTVSLKDGAVKHLVGGERDPMNLFAFGDVDGVGINAKLQHPLGVTWDK 491 Query: 197 RYDYILATASADSRVKLWDVRRASGCLI--TLDQHNGKKSQAVESANTAHNGKVNGLCFT 254 + + + S + ++K+ D + + + T D +N S ES + GLC Sbjct: 492 KRNLLYVADSYNHKIKVVDPKTKNCTTLAGTGDTNNVTSSSFTESTFN----EPGGLCIG 547 Query: 255 SDGLHLLTVGTDN 267 +G L T+N Sbjct: 548 ENGELLYVADTNN 560 >5MWJ-A nrPDB Length = 337 Score = 28.9 bits (63), Expect = 4.5, Method: Compositional matrix adjust. Identities = 28/155 (18%), Positives = 55/155 (35%), Gaps = 22/155 (14%) Query: 211 VKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMR 270 VK+WD+ H G KS + + + DG L+ G + + Sbjct: 74 VKVWDI-----------SHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLS 122 Query: 271 LWN----SSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQ 326 +W+ + + L + C V C S+ IAV+ +++ Sbjct: 123 IWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSD-------GNIAVWDLHNQTL 175 Query: 327 ITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 + +GH C ++ +L++G D + +W Sbjct: 176 VRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSW 210 Score = 27.7 bits (60), Expect = 9.9, Method: Compositional matrix adjust. Identities = 37/143 (25%), Positives = 55/143 (38%), Gaps = 24/143 (16%) Query: 150 SPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEI----LAVSWSPRYDYILATA 205 SPVS CL R ++ C L C+ I+ G + LA +PR L ++ Sbjct: 86 SPVSQLDCL----NRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAP-TPRIKAELTSS 140 Query: 206 ---------SADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD 256 S DS+V + G + D HN Q + H + + ++D Sbjct: 141 APACYALAISPDSKVCF--SCCSDGNIAVWDLHN----QTLVRQFQGHTDGASCIDISND 194 Query: 257 GLHLLTVGTDNRMRLWNSSNGEN 279 G L T G DN +R W+ G Sbjct: 195 GTKLWTGGLDNTVRSWDLREGRQ 217 >3BG0-A nrPDB Length = 316 Score = 28.5 bits (62), Expect = 4.9, Method: Compositional matrix adjust. Identities = 39/197 (19%), Positives = 71/197 (36%), Gaps = 44/197 (22%) Query: 53 PVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDT 112 P+ G + S D ++++ EN + + + +H H SV +V W PHD Sbjct: 68 PMYGNILASCSYDRKVIIWREENGTWEKSH----------EHAG-HDSSVNSVCWAPHDY 116 Query: 113 GMFTS-SSFDKTLKV--------WDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGT 163 G+ + S D + + W+ + A ++ + P S L+ + Sbjct: 117 GLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGS----LIDHPS 172 Query: 164 RGPKVQLCDLKSGSCSHI-----------------LQGHRQEILAVSWSPRYDY---ILA 203 + SG C ++ L+ H + V+W+P +A Sbjct: 173 GQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232 Query: 204 TASADSRVKLWDVRRAS 220 + S D RV +W AS Sbjct: 233 SCSQDGRVFIWTCDDAS 249 >5K19-A nrPDB Length = 569 Score = 28.5 bits (62), Expect = 4.9, Method: Compositional matrix adjust. Identities = 23/94 (24%), Positives = 40/94 (42%), Gaps = 9/94 (9%) Query: 277 GENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIA---------VYTVYSGEQI 327 GE+ V+ K + LK+TV G +EF F P G +A V+ S E Sbjct: 196 GESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELH 255 Query: 328 TMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 +K ++ + C + + + + +G D + W Sbjct: 256 GTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVW 289 >5WLC-LH nrPDB Length = 896 Score = 28.5 bits (62), Expect = 5.5, Method: Compositional matrix adjust. Identities = 12/25 (48%), Positives = 19/25 (76%) Query: 55 EGRYMLSGGSDGVIVLYDLENSSRQ 79 +G Y+LSGG + V+ L+ LE +S+Q Sbjct: 308 DGSYLLSGGWEKVMSLWQLETNSQQ 332 >5MC6-j nrPDB Length = 397 Score = 28.5 bits (62), Expect = 6.0, Method: Compositional matrix adjust. Identities = 28/136 (20%), Positives = 49/136 (36%), Gaps = 25/136 (18%) Query: 158 LVAVGTRGPKVQLCDLKS------GSCSHILQGHRQEILAVSWSPRYDYILATASADSRV 211 L+A G VQ+ +L + H + + I +V +SP+ + ++S Sbjct: 199 LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLAIAHDSNSF- 257 Query: 212 KLWDVRRASGCLITLDQHNGKK---------SQAVESANTAHNGKVNGLCFTSDGLHLLT 262 GC+ + G++ S AH+ V L F G L + Sbjct: 258 ---------GCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCS 308 Query: 263 VGTDNRMRLWNSSNGE 278 G D ++R W+ E Sbjct: 309 AGWDGKLRFWDVKTKE 324 >6F1U-h nrPDB Length = 612 Score = 28.1 bits (61), Expect = 7.0, Method: Compositional matrix adjust. Identities = 18/84 (21%), Positives = 33/84 (39%), Gaps = 11/84 (13%) Query: 144 VYSHHMSPVSTKHCLVAVGTRGPK-----------VQLCDLKSGSCSHILQGHRQEILAV 192 ++ H P++ HC AVG V+L K+ + + + + V Sbjct: 445 MFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNNKPLYSFEDNAGYVYDV 504 Query: 193 SWSPRYDYILATASADSRVKLWDV 216 WSP + + A R+ LW++ Sbjct: 505 MWSPTHPALFACVDGMGRLDLWNL 528 >4GKL-A nrPDB Length = 422 Score = 28.1 bits (61), Expect = 7.4, Method: Compositional matrix adjust. Identities = 17/42 (40%), Positives = 24/42 (57%), Gaps = 9/42 (21%) Query: 21 AESTRRVLGLELNKDRDVERIHGGGINTLDIEP-----VEGR 57 E ++ L LE +D+ER+ G GINT+ + P VEGR Sbjct: 18 GEKGKKFLSLE----KDLERLKGMGINTVWLMPIHPTGVEGR 55 >6C0F-s nrPDB Length = 807 Score = 28.1 bits (61), Expect = 7.6, Method: Compositional matrix adjust. Identities = 14/39 (35%), Positives = 23/39 (58%), Gaps = 1/39 (2%) Query: 178 CSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 CS I GH+ ++ +S P + LAT S D V++W++ Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGLW-LATGSDDGTVRVWEI 466 >6EM1-m nrPDB Length = 807 Score = 27.7 bits (60), Expect = 8.5, Method: Compositional matrix adjust. Identities = 14/39 (35%), Positives = 23/39 (58%), Gaps = 1/39 (2%) Query: 178 CSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 CS I GH+ ++ +S P + LAT S D V++W++ Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGLW-LATGSDDGTVRVWEI 466 >6CB1-s nrPDB Length = 569 Score = 27.7 bits (60), Expect = 9.4, Method: Compositional matrix adjust. Identities = 14/39 (35%), Positives = 23/39 (58%), Gaps = 1/39 (2%) Query: 178 CSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 CS I GH+ ++ +S P + LAT S D V++W++ Sbjct: 191 CSTIYAGHKGKVRTLSIDPSGLW-LATGSDDGTVRVWEI 228 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4A11-B nrPDB 487 e-138 5MZH-A nrPDB 245 3e-65 6QX9-5O nrPDB 218 3e-57 5M25-A nrPDB 213 1e-55 5NNZ-B nrPDB 212 3e-55 2H9P-A nrPDB 205 3e-53 4V6W-Ag nrPDB 203 1e-52 6F3T-A nrPDB 195 3e-50 3DM0-A nrPDB 195 3e-50 3JAP-g nrPDB 192 2e-49 6G51-g nrPDB 189 1e-48 6MZM-G nrPDB 187 6e-48 4V7E-Bg nrPDB 187 1e-47 5NZU-C nrPDB 187 1e-47 5FL8-q nrPDB 187 1e-47 6HHQ-h nrPDB 186 1e-47 1VYH-C nrPDB 185 3e-47 4V8M-A7 nrPDB 183 1e-46 3C9C-A nrPDB 182 2e-46 5G04-R nrPDB 181 5e-46 5OPT-p nrPDB 180 7e-46 4GGA-A nrPDB 178 4e-45 6HQA-B nrPDB 178 4e-45 5Y1U-A nrPDB 178 5e-45 5LCW-Q nrPDB 177 8e-45 5WJC-A nrPDB 175 3e-44 5YZG-W nrPDB 174 6e-44 6QDV-o nrPDB 174 6e-44 3CFV-B nrPDB 173 1e-43 5Y88-O nrPDB 168 3e-42 5XYI-g nrPDB 167 6e-42 4N14-A nrPDB 165 3e-41 5GAN-H nrPDB 164 6e-41 3MKQ-A nrPDB 163 9e-41 5WLC-LO nrPDB 162 4e-40 4XYI-A nrPDB 161 6e-40 5FVM-C nrPDB 160 1e-39 2YNP-A nrPDB 159 2e-39 5I2T-A nrPDB 159 2e-39 3JB9-g nrPDB 157 1e-38 6QX9-4B nrPDB 156 2e-38 3FM0-A nrPDB 155 5e-38 6ID0-T nrPDB 152 2e-37 6EMK-B nrPDB 152 3e-37 4BTS-AR nrPDB 148 4e-36 5WYJ-BC nrPDB 145 2e-35 4AEZ-A nrPDB 145 3e-35 3JB9-L nrPDB 145 3e-35 5Z56-q nrPDB 145 4e-35 6Q8F-A nrPDB 142 2e-34 4E5Z-B nrPDB 140 9e-34 4PSX-B nrPDB 139 2e-33 4LG8-A nrPDB 139 2e-33 5OQL-L nrPDB 137 1e-32 5L9T-R nrPDB 135 3e-32 6ELZ-p nrPDB 130 8e-31 5WBU-D nrPDB 130 1e-30 5CXC-A nrPDB 130 2e-30 2HES-X nrPDB 129 2e-30 5K1B-B nrPDB 129 2e-30 5WYK-BB nrPDB 128 5e-30 6EOJ-D nrPDB 126 1e-29 5WLC-LJ nrPDB 126 2e-29 1NR0-A nrPDB 123 1e-28 6J6H-n nrPDB 120 9e-28 5OQL-J nrPDB 116 2e-26 5A31-R nrPDB 115 5e-26 3W15-A nrPDB 114 6e-26 4BH6-A nrPDB 113 2e-25 2PM9-A nrPDB 110 2e-24 5M89-A nrPDB 107 7e-24 2AQ5-A nrPDB 100 2e-21 3EI3-B nrPDB 99 2e-21 5BJS-A nrPDB 99 4e-21 Sequences not found previously or not previously below threshold: 6N9G-C nrPDB 155 2e-38 5UZ7-B nrPDB 142 2e-34 6GMH-W nrPDB 134 9e-32 4YCZ-A nrPDB 120 9e-28 5WLC-LU nrPDB 120 1e-27 4J0W-A nrPDB 117 8e-27 4XFV-A nrPDB 116 1e-26 4L9O-A nrPDB 116 2e-26 6BX3-A nrPDB 115 3e-26 5OQL-d nrPDB 113 2e-25 6CHG-A nrPDB 111 4e-25 3JRO-A nrPDB 110 9e-25 3JRP-A nrPDB 102 2e-22 5MWJ-A nrPDB 101 4e-22 3ODT-A nrPDB 99 2e-21 4BZK-B nrPDB 100 2e-21 5K0Y-T nrPDB 99 4e-21 5WYJ-BE nrPDB 96 2e-20 5FA5-B nrPDB 96 3e-20 5A9Q-7 nrPDB 95 4e-20 3BG0-A nrPDB 94 1e-19 5N4A-A nrPDB 93 2e-19 4U1E-I nrPDB 93 2e-19 1PI6-A nrPDB 92 3e-19 4OWR-A nrPDB 92 3e-19 6CB1-s nrPDB 91 7e-19 6C0F-s nrPDB 91 1e-18 6EM1-m nrPDB 90 1e-18 3ACP-A nrPDB 88 5e-18 4G56-B nrPDB 88 7e-18 6F1U-h nrPDB 87 1e-17 3F3P-A nrPDB 84 8e-17 5OQL-X nrPDB 84 1e-16 3JZG-A nrPDB 83 3e-16 3I2N-A nrPDB 81 7e-16 6BX3-B nrPDB 80 1e-15 5YZG-2 nrPDB 80 2e-15 4J0X-A nrPDB 78 9e-15 5WLC-SG nrPDB 77 1e-14 5WLC-LN nrPDB 76 2e-14 6CHG-D nrPDB 76 3e-14 5CXB-B nrPDB 75 6e-14 2P9P-C nrPDB 75 7e-14 6E29-D nrPDB 74 1e-13 5OV3-A nrPDB 73 1e-13 3JB9-S nrPDB 73 3e-13 5A9Q-0 nrPDB 70 1e-12 5MC6-j nrPDB 70 2e-12 5WLC-LH nrPDB 69 3e-12 5A9Q-2 nrPDB 68 5e-12 3DW8-B nrPDB 67 1e-11 5K19-A nrPDB 62 5e-10 5AMS-A nrPDB 61 6e-10 6CVZ-A nrPDB 55 4e-08 3DWL-C nrPDB 54 1e-07 5WLC-LS nrPDB 54 1e-07 2VDU-B nrPDB 53 2e-07 5WLC-LV nrPDB 50 1e-06 5WLC-LW nrPDB 50 2e-06 5LTD-A nrPDB 50 2e-06 2I3T-A nrPDB 50 3e-06 5TF2-A nrPDB 48 6e-06 6IYY-A nrPDB 48 8e-06 5AJA-A nrPDB 45 7e-05 6N8P-A nrPDB 43 2e-04 4AV8-A nrPDB 42 6e-04 3WJ9-A nrPDB 41 8e-04 4YHC-A nrPDB 38 0.008 4FHN-A nrPDB 38 0.011 5GRS-A nrPDB 37 0.014 5L8S-A nrPDB 36 0.033 5CWW-B nrPDB 35 0.084 5BPT-A nrPDB 34 0.15 5BPW-A nrPDB 33 0.24 6IGR-A nrPDB 33 0.26 2XE4-A nrPDB 33 0.28 6NAU-A nrPDB 31 0.67 4IMM-A nrPDB 31 0.99 3R3L-A nrPDB 30 1.8 5V8F-D nrPDB 30 2.0 1RI6-A nrPDB 30 2.4 2GBG-A nrPDB 29 3.1 5SUM-A nrPDB 29 3.3 3MWP-A nrPDB 29 4.0 5WLC-LK nrPDB 29 4.1 3K89-A nrPDB 29 4.8 4WJL-A nrPDB 28 5.2 3TMG-A nrPDB 28 6.1 1BWR-A nrPDB 28 6.5 >4A11-B nrPDB Length = 408 Score = 487 bits (1252), Expect = e-138, Method: Composition-based stats. Identities = 396/396 (100%), Positives = 396/396 (100%) Query: 1 MLGFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYML 60 MLGFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYML Sbjct: 1 MLGFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYML 60 Query: 61 SGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSF 120 SGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSF Sbjct: 61 SGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSF 120 Query: 121 DKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSH 180 DKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSH Sbjct: 121 DKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSH 180 Query: 181 ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA 240 ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA Sbjct: 181 ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA 240 Query: 241 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS 300 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS Sbjct: 241 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS 300 Query: 301 CGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA 360 CGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA Sbjct: 301 CGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA 360 Query: 361 WVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDEEG 396 WVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDEEG Sbjct: 361 WVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDEEG 396 >5MZH-A nrPDB Length = 452 Score = 245 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 69/349 (19%), Positives = 125/349 (35%), Gaps = 40/349 (11%) Query: 14 DPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDL 73 D + T +V ++ H + + G +++G D L+D Sbjct: 107 DRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDA 166 Query: 74 ENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ 133 Q YYT K H+ + + + P + + + S D T K+WD T Q Sbjct: 167 YTG--QLYYTLKG-----------HQTEIVCLSFNP-QSTIIATGSMDNTAKLWDVETGQ 212 Query: 134 TADVF-NFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAV 192 + S + T L+ G+ +L D+++G C H+L GHR E+ + Sbjct: 213 ERATLAGHRAEIVSLGFN---TGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSST 269 Query: 193 SWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLC 252 ++ ++ + S D +LWDVR S H +V + Sbjct: 270 QFNYAG-TLVVSGSIDCTSRLWDVRSGR----------------CLSVKQGHTDEVLDVA 312 Query: 253 FTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPY 312 F + G +++ D RL+++ G G SK + + Sbjct: 313 FDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISK-----VAFNPQGTRLITASS 367 Query: 313 GSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 T ++ +GE + +L+GH + C F + +GS+D W Sbjct: 368 DKTCRLWDCDTGECLQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCRIW 416 Score = 141 bits (355), Expect = 4e-34, Method: Composition-based stats. Identities = 48/268 (17%), Positives = 87/268 (32%), Gaps = 26/268 (9%) Query: 125 KVWDTNTLQTADVFNFEETVYSHHMS----PVSTKHCLVAVGTRGPKVQLCDLKSGSCSH 180 ++ D Q F + + +H + + G+ ++ + +G Sbjct: 71 RLIDKMLEQQHHSFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVF 130 Query: 181 ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA 240 L+GH+ + A++++ Y + T S D KLWD + Sbjct: 131 TLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQ----------------LYYT 174 Query: 241 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS 300 H ++ L F + T DN +LW+ G+ G G Sbjct: 175 LKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFN---- 230 Query: 301 CGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA 360 V + ++ V +G+ + +L GH V F + SGS DC Sbjct: 231 -TGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRL 289 Query: 361 WVPSLYEPVPDDDETTTKSQLNPAFEDA 388 W + + T L+ AF+ A Sbjct: 290 WDVRSGRCLSVK-QGHTDEVLDVAFDAA 316 Score = 101 bits (252), Expect = 5e-22, Method: Composition-based stats. Identities = 31/152 (20%), Positives = 50/152 (32%), Gaps = 4/152 (2%) Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 +R+ LI S + AH + F G +T D ++WN+ Sbjct: 65 LRQLIHRLIDKMLEQQHHSFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTF 124 Query: 276 NGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYK 335 GE G N + F + V + T ++ Y+G+ LKGH Sbjct: 125 TGEEVFTLEG--HKNVVYAIAFN--NPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQT 180 Query: 336 TVDCCVFQSNFQELYSGSRDCNILAWVPSLYE 367 + C F + +GS D W + Sbjct: 181 EIVCLSFNPQSTIIATGSMDNTAKLWDVETGQ 212 Score = 58.0 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 28/77 (36%), Gaps = 1/77 (1%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 L ++ T R+ + + V H I + EG ++++G D ++ Sbjct: 362 LITASSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFN-YEGDFIITGSKDNTCRIWKALT 420 Query: 76 SSRQSYYTCKAVCSIGR 92 +S Q A + R Sbjct: 421 ASSQPAGPGGAGGGLAR 437 >6QX9-5O nrPDB Length = 357 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 72/334 (21%), Positives = 129/334 (38%), Gaps = 38/334 (11%) Query: 31 ELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSI 90 L + H G + P G + S G D +I+L+++ +Y T K Sbjct: 54 SLQAPIMLLSGHEGEVYCCKFHP-NGSTLASAGFDRLILLWNVYGDCD-NYATLKG---- 107 Query: 91 GRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMS 150 H +V + + D M S+S DKT+ VWD+ T + T + + Sbjct: 108 -------HSGAVMELHYN-TDGSMLFSASTDKTVAVWDSETGERVKRLK-GHTSFVNSCY 158 Query: 151 PVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSR 210 P LV G+ V+L D++ + Q + ++LAV+++ D I+ + D+ Sbjct: 159 PARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQII-SGGIDND 216 Query: 211 VKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMR 270 +K+WD+R+ + H V GL +S+G +LL+ DN +R Sbjct: 217 IKVWDLRQ----------------NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVR 260 Query: 271 LWNSS----NGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQ 326 +W+ + G V N K L+ + S+ + V+ S Sbjct: 261 VWDVRPFAPKERCVKIFQGNVHNFEKNLLRCS-WSPDGSKIAAGSADRFVYVWDTTSRRI 319 Query: 327 ITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA 360 + L GH +++ F + + S S D + Sbjct: 320 LYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 39/233 (16%), Positives = 71/233 (30%), Gaps = 30/233 (12%) Query: 139 NFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSC--SHILQGHRQEILAVSWSP 196 E VY P + +A + L ++ G C L+GH ++ + ++ Sbjct: 64 GHEGEVYCCKFHPNGST---LASAGFDRLILLWNV-YGDCDNYATLKGHSGAVMELHYNT 119 Query: 197 RYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD 256 +L +AS D V +WD H VN Sbjct: 120 DGS-MLFSASTDKTVAVWDSETGERVKR----------------LKGHTSFVNSCYPARR 162 Query: 257 GLHLL-TVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGST 315 G L+ T D ++LW+ + + S + + + Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQT------FQNTYQVLAVTFNDTSDQIISGGIDND 216 Query: 316 IAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEP 368 I V+ + + ++GH +V S L S + D + W + P Sbjct: 217 IKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAP 269 Score = 124 bits (310), Expect = 8e-29, Method: Composition-based stats. Identities = 50/264 (18%), Positives = 89/264 (33%), Gaps = 42/264 (15%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 L + T V E + + H +N+ + + +G DG + L+D+ Sbjct: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK 183 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 + + Y V V + + S D +KVWD Q Sbjct: 184 KAAIQTFQN--------------TYQVLAVTFN-DTSDQIISGGIDNDIKVWDLR--QNK 226 Query: 136 DVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLK----SGSCSHILQGH----RQ 187 + S +S++ + V++ D++ C I QG+ + Sbjct: 227 LTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEK 286 Query: 188 EILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGK 247 +L SWSP I A SAD V +WD S+ + H G Sbjct: 287 NLLRCSWSPDGSKI-AAGSADRFVYVWD----------------TTSRRILYKLPGHAGS 329 Query: 248 VNGLCFTSDGLHLLTVGTDNRMRL 271 +N + F D +++ +D R+ + Sbjct: 330 INEVAFHPDEPIIISASSDKRLYM 353 Score = 76.1 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 28/159 (17%), Positives = 55/159 (34%), Gaps = 13/159 (8%) Query: 14 DPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDL 73 D + ++ +V L NK R H + L + EG Y+LS D + ++D+ Sbjct: 206 DQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLS-SEGSYLLSNAMDNTVRVWDV 264 Query: 74 ENSSRQSYYTCKAVCSIGRDHPDVHR--YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNT 131 C + +VH ++ W P D + S D+ + VWDT + Sbjct: 265 R--PFAPKERCVKIFQ-----GNVHNFEKNLLRCSWSP-DGSKIAAGSADRFVYVWDTTS 316 Query: 132 LQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQL 170 + S + ++ + ++ + Sbjct: 317 RRILYKLPGHAG--SINEVAFHPDEPIIISASSDKRLYM 353 Score = 53.0 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 17/72 (23%), Positives = 26/72 (36%), Gaps = 3/72 (4%) Query: 302 GCSSEFVFVPYGSTIAVYTVYSGEQ--ITMLKGHYKTVDCCVFQSNFQELYSGSRDCNIL 359 S + I ++ VY G+ LKGH V + ++ L+S S D + Sbjct: 76 PNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVA 134 Query: 360 AWVPSLYEPVPD 371 W E V Sbjct: 135 VWDSETGERVKR 146 Score = 46.1 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 15/39 (38%), Positives = 16/39 (41%) Query: 325 EQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVP 363 I +L GH V CC F N L S D IL W Sbjct: 57 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV 95 >5M25-A nrPDB Length = 434 Score = 213 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 66/326 (20%), Positives = 128/326 (39%), Gaps = 39/326 (11%) Query: 41 IHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRY 100 H ++++ P G ++ S +D +I ++ + + H+ Sbjct: 143 GHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTI-------------SGHKL 188 Query: 101 SVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEET-VYSHHMSPVSTKHCLV 159 + V W D+ + S+S DKTLK+WD ++ + V+ + +P S L+ Sbjct: 189 GISDVAWSS-DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS---NLI 244 Query: 160 AVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRA 219 G+ V++ D+K+G C L H + AV ++ ++ ++S D ++WD + Sbjct: 245 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS-LIVSSSYDGLCRIWDT-AS 302 Query: 220 SGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEN 279 CL TL + N V+ + F+ +G ++L DN ++LW+ S G+ Sbjct: 303 GQCLKTLIDDD--------------NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 348 Query: 280 TLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDC 339 G N K + S V + + ++ + + E + L+GH V Sbjct: 349 LKTYTG--HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 406 Query: 340 CVFQSNFQELYSGS--RDCNILAWVP 363 + S + D I W Sbjct: 407 TACHPTENIIASAALENDKTIKLWKS 432 Score = 153 bits (387), Expect = 8e-38, Method: Composition-based stats. Identities = 56/309 (18%), Positives = 106/309 (34%), Gaps = 43/309 (13%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 L A+ ++ G K H GI+ + + ++S D + ++D+ + Sbjct: 160 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS-SDSNLLVSASDDKTLKIWDVSS 218 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 H V + P + + S SFD+++++WD T + Sbjct: 219 GKCLKTLKG-------------HSNYVFCCNFNP-QSNLIVSGSFDESVRIWDVKTGKCL 264 Query: 136 DVFN-FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHIL-QGHRQEILAVS 193 + V + H + L+ + ++ D SG C L + V Sbjct: 265 KTLPAHSDPVSAVHFN---RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 321 Query: 194 WSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCF 253 +SP YILA A+ D+ +KLWD CL T H +K + + Sbjct: 322 FSPNGKYILA-ATLDNTLKLWD-YSKGKCLKTYTGHKNEKYCIFANFSV----------- 368 Query: 254 TSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPY- 312 + G +++ DN + +WN E G + + +C + + Sbjct: 369 -TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT------DVVISTACHPTENIIASAAL 421 Query: 313 --GSTIAVY 319 TI ++ Sbjct: 422 ENDKTIKLW 430 Score = 147 bits (371), Expect = 7e-36, Method: Composition-based stats. Identities = 41/260 (15%), Positives = 85/260 (32%), Gaps = 36/260 (13%) Query: 20 RAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQ 79 + T ++ + K + H + + P + ++SG D + ++D++ Sbjct: 206 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWDVKTGK-- 262 Query: 80 SYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN 139 C H V V + D + SSS+D ++WDT + Q Sbjct: 263 ----CLKTLP-------AHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTL- 309 Query: 140 FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAV--SWSPR 197 ++ S + T ++L D G C GH+ E + ++S Sbjct: 310 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 369 Query: 198 YDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDG 257 + + S D+ V +W++ +++ + H V Sbjct: 370 GGKWIVSGSEDNLVYIWNL----------------QTKEIVQKLQGHTDVVISTACHPTE 413 Query: 258 LHLLTVG--TDNRMRLWNSS 275 + + D ++LW S Sbjct: 414 NIIASAALENDKTIKLWKSD 433 Score = 141 bits (355), Expect = 5e-34, Method: Composition-based stats. Identities = 48/264 (18%), Positives = 90/264 (34%), Gaps = 36/264 (13%) Query: 138 FNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPR 197 F + S +A + +++ G + GH+ I V+WS Sbjct: 139 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 198 Query: 198 YDYILATASADSRVKLWDVRRASGCLITLDQHN--------------------------- 230 +L +AS D +K+WDV CL TL H+ Sbjct: 199 -SNLLVSASDDKTLKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 256 Query: 231 GKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNN 290 K+ AH+ V+ + F DG +++ D R+W++++G+ + ++ Sbjct: 257 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKT----LIDD 312 Query: 291 SKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCC--VFQ-SNFQ 347 + F + +T+ ++ G+ + GH C F + + Sbjct: 313 DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 372 Query: 348 ELYSGSRDCNILAWVPSLYEPVPD 371 + SGS D + W E V Sbjct: 373 WIVSGSEDNLVYIWNLQTKEIVQK 396 Score = 115 bits (287), Expect = 4e-26, Method: Composition-based stats. Identities = 33/151 (21%), Positives = 61/151 (40%), Gaps = 5/151 (3%) Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN 276 + G K + A++ H V+ + F+ +G L + D +++W + + Sbjct: 117 EQIGGSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD 176 Query: 277 GENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKT 336 G+ + K + K G+ S+ V T+ ++ V SG+ + LKGH Sbjct: 177 GK-----FEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY 231 Query: 337 VDCCVFQSNFQELYSGSRDCNILAWVPSLYE 367 V CC F + SGS D ++ W + Sbjct: 232 VFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 262 >5NNZ-B nrPDB Length = 415 Score = 212 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 62/347 (17%), Positives = 117/347 (33%), Gaps = 40/347 (11%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 + T ++ ++ + H + + G + +G D L+ +E Sbjct: 107 FITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVET 166 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 + H + + + P + + + S D T K+WD + Sbjct: 167 GKCYHTFRG-------------HTAEIVCLSFNP-QSTLVATGSMDTTAKLWDIQNGEEV 212 Query: 136 DVF-NFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSW 194 + S + T + G+ V + D +G +IL GH EI + S+ Sbjct: 213 YTLRGHSAEIISLSFN---TSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASF 269 Query: 195 SPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFT 254 + IL T S D KLWD C+ TL T H+ ++ CF Sbjct: 270 NWDCSLIL-TGSMDKTCKLWDA-TNGKCVATL---------------TGHDDEILDSCFD 312 Query: 255 SDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGS 314 G + T D R+++++ + G SK + + Sbjct: 313 YTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN-----PQGNHLLTGSSDK 367 Query: 315 TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 T ++ +G+ + +L+GH + C F + +GS+D W Sbjct: 368 TARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414 Score = 202 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 67/331 (20%), Positives = 117/331 (35%), Gaps = 40/331 (12%) Query: 38 VERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDV 97 V + H + + + G ++G D L+D + + + Sbjct: 87 VLKAHILPLTNVALN-KSGSCFITGSYDRTCKLWDTASGEELNTL-------------EG 132 Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF-NFEETVYSHHMSPVSTKH 156 HR V + + + SFDKT K+W T + F + +P ST Sbjct: 133 HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST-- 190 Query: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 LVA G+ +L D+++G + L+GH EI+++S++ D I+ T S D V +WD Sbjct: 191 -LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII-TGSFDHTVVVWDA 248 Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN 276 I H +++ F D +LT D +LW+++N Sbjct: 249 DTGRKVNI----------------LIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292 Query: 277 GENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKT 336 G+ G +T T +++ + + I L+GH Sbjct: 293 GKCVATLTGHDDEILDSCFDYT-----GKLIATASADGTARIFSAATRKCIAKLEGHEGE 347 Query: 337 VDCCVFQSNFQELYSGSRDCNILAWVPSLYE 367 + F L +GS D W + Sbjct: 348 ISKISFNPQGNHLLTGSSDKTARIWDAQTGQ 378 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 62/308 (20%), Positives = 112/308 (36%), Gaps = 41/308 (13%) Query: 14 DPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDL 73 D + + T ++ +E K R H I L P + + +G D L+D+ Sbjct: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNP-QSTLVATGSMDTTAKLWDI 206 Query: 74 ENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ 133 +N YT + H + ++ + + SFD T+ VWD +T + Sbjct: 207 QNGEE--VYTLRG-----------HSAEIISLSFN-TSGDRIITGSFDHTVVVWDADTGR 252 Query: 134 TADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVS 193 ++ + + L+ G+ +L D +G C L GH EIL Sbjct: 253 KVNILIGH--CAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310 Query: 194 WSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCF 253 + ++ATASAD +++ C+ L+ H G+++ + F Sbjct: 311 FDYTG-KLIATASADGTARIFSA-ATRKCIAKLE---------------GHEGEISKISF 353 Query: 254 TSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPY- 312 G HLLT +D R+W++ G+ V G F+ + V Sbjct: 354 NPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHT------DEIFSCAFNYKGNIVITGSK 407 Query: 313 GSTIAVYT 320 +T ++ Sbjct: 408 DNTCRIWR 415 Score = 191 bits (484), Expect = 5e-49, Method: Composition-based stats. Identities = 55/313 (17%), Positives = 116/313 (37%), Gaps = 26/313 (8%) Query: 59 MLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSS 118 +L+ + L L ++ H + V F + Sbjct: 54 LLTASRTEQVKL--LIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALN-KSGSCFITG 110 Query: 119 SFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSC 178 S+D+T K+WDT + + + V ++ + +A G+ +L +++G C Sbjct: 111 SYDRTCKLWDTASGEELNTLEGHRNVVYA-IAFNNPYGDKIATGSFDKTCKLWSVETGKC 169 Query: 179 SHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVE 238 H +GH EI+ +S++P+ ++AT S D+ KLWD++ + TL Sbjct: 170 YHTFRGHTAEIVCLSFNPQ-STLVATGSMDTTAKLWDIQN-GEEVYTL------------ 215 Query: 239 SANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFT 298 H+ ++ L F + G ++T D+ + +W++ G + G S + Sbjct: 216 ---RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWD 272 Query: 299 VSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNI 358 S + T ++ +G+ + L GH + F + + + S D Sbjct: 273 CS-----LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTA 327 Query: 359 LAWVPSLYEPVPD 371 + + + + Sbjct: 328 RIFSAATRKCIAK 340 >2H9P-A nrPDB Length = 329 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 66/326 (20%), Positives = 128/326 (39%), Gaps = 39/326 (11%) Query: 41 IHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRY 100 H ++++ P G ++ S +D +I ++ + + H+ Sbjct: 38 GHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTI-------------SGHKL 83 Query: 101 SVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEET-VYSHHMSPVSTKHCLV 159 + V W D+ + S+S DKTLK+WD ++ + V+ + +P S L+ Sbjct: 84 GISDVAWSS-DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS---NLI 139 Query: 160 AVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRA 219 G+ V++ D+K+G C L H + AV ++ ++ ++S D ++WD + Sbjct: 140 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS-LIVSSSYDGLCRIWDT-AS 197 Query: 220 SGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEN 279 CL TL + N V+ + F+ +G ++L DN ++LW+ S G+ Sbjct: 198 GQCLKTLIDDD--------------NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 243 Query: 280 TLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDC 339 G N K + S V + + ++ + + E + L+GH V Sbjct: 244 LKTYTG--HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 301 Query: 340 CVFQSNFQELYSGS--RDCNILAWVP 363 + S + D I W Sbjct: 302 TACHPTENIIASAALENDKTIKLWKS 327 Score = 147 bits (371), Expect = 7e-36, Method: Composition-based stats. Identities = 56/309 (18%), Positives = 106/309 (34%), Gaps = 43/309 (13%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 L A+ ++ G K H GI+ + + ++S D + ++D+ + Sbjct: 55 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS-SDSNLLVSASDDKTLKIWDVSS 113 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 H V + P + + S SFD+++++WD T + Sbjct: 114 GKCLKTLKG-------------HSNYVFCCNFNP-QSNLIVSGSFDESVRIWDVKTGKCL 159 Query: 136 DVFN-FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHIL-QGHRQEILAVS 193 + V + H + L+ + ++ D SG C L + V Sbjct: 160 KTLPAHSDPVSAVHFN---RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 216 Query: 194 WSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCF 253 +SP YILA A+ D+ +KLWD CL T H +K + + Sbjct: 217 FSPNGKYILA-ATLDNTLKLWD-YSKGKCLKTYTGHKNEKYCIFANFSV----------- 263 Query: 254 TSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPY- 312 + G +++ DN + +WN E G + + +C + + Sbjct: 264 -TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT------DVVISTACHPTENIIASAAL 316 Query: 313 --GSTIAVY 319 TI ++ Sbjct: 317 ENDKTIKLW 325 Score = 141 bits (356), Expect = 3e-34, Method: Composition-based stats. Identities = 41/260 (15%), Positives = 85/260 (32%), Gaps = 36/260 (13%) Query: 20 RAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQ 79 + T ++ + K + H + + P + ++SG D + ++D++ Sbjct: 101 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWDVKTGK-- 157 Query: 80 SYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN 139 C H V V + D + SSS+D ++WDT + Q Sbjct: 158 ----CLKTLP-------AHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTL- 204 Query: 140 FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAV--SWSPR 197 ++ S + T ++L D G C GH+ E + ++S Sbjct: 205 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 264 Query: 198 YDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDG 257 + + S D+ V +W++ +++ + H V Sbjct: 265 GGKWIVSGSEDNLVYIWNL----------------QTKEIVQKLQGHTDVVISTACHPTE 308 Query: 258 LHLLTVG--TDNRMRLWNSS 275 + + D ++LW S Sbjct: 309 NIIASAALENDKTIKLWKSD 328 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 48/264 (18%), Positives = 90/264 (34%), Gaps = 36/264 (13%) Query: 138 FNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPR 197 F + S +A + +++ G + GH+ I V+WS Sbjct: 34 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 93 Query: 198 YDYILATASADSRVKLWDVRRASGCLITLDQHN--------------------------- 230 +L +AS D +K+WDV CL TL H+ Sbjct: 94 -SNLLVSASDDKTLKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 151 Query: 231 GKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNN 290 K+ AH+ V+ + F DG +++ D R+W++++G+ + ++ Sbjct: 152 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKT----LIDD 207 Query: 291 SKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCC--VFQ-SNFQ 347 + F + +T+ ++ G+ + GH C F + + Sbjct: 208 DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 267 Query: 348 ELYSGSRDCNILAWVPSLYEPVPD 371 + SGS D + W E V Sbjct: 268 WIVSGSEDNLVYIWNLQTKEIVQK 291 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 32/136 (23%), Positives = 59/136 (43%), Gaps = 5/136 (3%) Query: 232 KKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNS 291 K + A++ H V+ + F+ +G L + D +++W + +G+ + K + Sbjct: 27 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK-----FEKTISGH 81 Query: 292 KKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYS 351 K G+ S+ V T+ ++ V SG+ + LKGH V CC F + S Sbjct: 82 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 141 Query: 352 GSRDCNILAWVPSLYE 367 GS D ++ W + Sbjct: 142 GSFDESVRIWDVKTGK 157 >4V6W-Ag nrPDB Length = 318 Score = 203 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 66/338 (19%), Positives = 133/338 (39%), Gaps = 48/338 (14%) Query: 41 IHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRY 100 H G + + P + ++S D ++++ L +Y + H + Sbjct: 13 GHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYG-------YPQKRLYGHSH 65 Query: 101 SVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF-NFEETVYSHHMSPVSTKHCLV 159 + V D S S+D+TL++WD +T F + V S S + + + Sbjct: 66 FISDVVLSS-DGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQ---I 121 Query: 160 AVGTRGPKVQLCDLKSGSCSHILQ--GHRQEILAVSWSPRYDY-ILATASADSRVKLWDV 216 G+R ++L + + C +Q GH + V +SP + I+ + D VK+W++ Sbjct: 122 VSGSRDKTIKLWNTLA-ECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNL 180 Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN 276 +++ + HNG +N + + DG + G D++ LW+ ++ Sbjct: 181 AN----------------CKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLND 224 Query: 277 GENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITML------ 330 G+N Y N+ L F+ + ++ V YG +I ++ + + + L Sbjct: 225 GKNL---YTLEHNDIINALCFS----PNRYWLCVAYGPSIKIWDLACKKTVEELRPEVVS 277 Query: 331 ---KGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSL 365 K + ++ Q L++G D I W S+ Sbjct: 278 PTSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQVSV 315 Score = 152 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 54/258 (20%), Positives = 104/258 (40%), Gaps = 26/258 (10%) Query: 19 RRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSR 78 + T R+ L K H + ++ + R ++SG D I L++ + Sbjct: 82 GSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFS-ADNRQIVSGSRDKTIKLWNTLAECK 140 Query: 79 QSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG-MFTSSSFDKTLKVWDTNTLQTADV 137 + D H V V++ P+ + + S +D+T+KVW+ + Sbjct: 141 FTIQE------------DGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCK-LKN 187 Query: 138 FNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPR 197 + Y + ++ VS L G + K L DL G + L+ H I A+ +SP Sbjct: 188 NHHGHNGYLNTVT-VSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE-HNDIINALCFSPN 245 Query: 198 YDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDG 257 ++ + +K+WD+ C T+++ + + V + A + L +++DG Sbjct: 246 RYWLCV--AYGPSIKIWDL----ACKKTVEE---LRPEVVSPTSKADQPQCLSLAWSTDG 296 Query: 258 LHLLTVGTDNRMRLWNSS 275 L +DN +R+W S Sbjct: 297 QTLFAGYSDNTIRVWQVS 314 Score = 106 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 34/191 (17%), Positives = 69/191 (36%), Gaps = 18/191 (9%) Query: 174 KSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKK 233 ++ L GH + ++ +P+ + +AS D + +W + + Sbjct: 3 ETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKL----------TRDEDTN 52 Query: 234 SQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKK 293 + H+ ++ + +SDG + L+ D +RLW+ + G+ T G K Sbjct: 53 YGYPQKRLYGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHT-----K 107 Query: 294 GLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITML-KGHYKTVDCCVFQSN--FQELY 350 + + + V TI ++ + + T+ GH V C F N + Sbjct: 108 DVLSVAFSADNRQIVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIV 167 Query: 351 SGSRDCNILAW 361 S D + W Sbjct: 168 SCGWDRTVKVW 178 >6F3T-A nrPDB Length = 608 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 64/274 (23%), Positives = 105/274 (38%), Gaps = 48/274 (17%) Query: 15 PLRLRRAESTRRVLGLELNKDRDVER--------------IHGGGINTLDIEPVEGRYML 60 P +LR + + ++ D +ER H G + P + Y+L Sbjct: 309 PKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSP-DRNYLL 367 Query: 61 SGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSF 120 S DG + L+ L+ + Y H Y V Q+ P+ F S Sbjct: 368 SSSEDGTVRLWSLQTFTCLVGYKG-------------HNYPVWDTQFSPYGY-YFVSGGH 413 Query: 121 DKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSH 180 D+ ++W T+ Q +F + + + VA G+ V+L D+ +G+C Sbjct: 414 DRVARLWATDHYQPLRIFAGH--LADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVR 471 Query: 181 ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA 240 I GH+ I ++++SP LAT + D RV LWD+ + Sbjct: 472 IFTGHKGPIHSLTFSPNGR-FLATGATDGRVLLWDIGHG----------------LMVGE 514 Query: 241 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 H V L F+ DG L + DN +RLW++ Sbjct: 515 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA 548 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 61/340 (17%), Positives = 107/340 (31%), Gaps = 53/340 (15%) Query: 45 GINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVET 104 G+ +D+ + + G +D + ++ + +S + I ++ Sbjct: 280 GLTAVDVT-DDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKE----------- 327 Query: 105 VQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF-NFEETVYSHHMSPVSTKHCLVAVGT 163 S D ++ D T + VY SP + + Sbjct: 328 --------------SDDVLERIMDEKTASELKILYGHSGPVYGASFSP---DRNYLLSSS 370 Query: 164 RGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCL 223 V+L L++ +C +GH + +SP Y Y + D +LW Sbjct: 371 EDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP-YGYYFVSGGHDRVARLWATDHYQPLR 429 Query: 224 ITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVN 283 I H VN F + ++ T D +RLW+ NG + Sbjct: 430 I----------------FAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIF 473 Query: 284 YGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQ 343 G K + + ++ + G + LKGH TV F Sbjct: 474 TGH-----KGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 528 Query: 344 SNFQELYSGSRDCNILAW-VPSLYEPVPDDDETTTKSQLN 382 + + L SGS D + W +E + DD TT +N Sbjct: 529 RDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHIN 568 >3DM0-A nrPDB Length = 694 Score = 195 bits (494), Expect = 3e-50, Method: Composition-based stats. Identities = 65/352 (18%), Positives = 118/352 (33%), Gaps = 61/352 (17%) Query: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 R H + + ++S D I+L+ L + + H Sbjct: 379 RAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKD--------DKAYGVAQRRLTGHS 430 Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF-NFEETVYSHHMSPVSTKHCL 158 + VE V D S S+D L++WD + F + V S S + + Sbjct: 431 HFVEDVVLSS-DGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQ--- 486 Query: 159 VAVGTRGPKVQLCDLKSGSCSHIL----QGHRQEILAVSWSPRY-DYILATASADSRVKL 213 + +R ++L + G C + + +GHR + V +SP + +AS D VK+ Sbjct: 487 IVSASRDRTIKLWN-TLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKV 545 Query: 214 WDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 W++ + S H G V+ + + DG + G D + LW+ Sbjct: 546 WNLSN----------------CKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWD 589 Query: 274 SSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGH 333 + G+ Y N+ L F+ + ++ I ++ + S + LK Sbjct: 590 LAEGKKL---YSLEANSVIHALCFS----PNRYWLCAATEHGIKIWDLESKSIVEDLKVD 642 Query: 334 YKT-------------------VDCCVFQSNFQELYSGSRDCNILAWVPSLY 366 K + ++ L+SG D I W Y Sbjct: 643 LKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLFSGYTDGVIRVWGIGRY 694 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 58/261 (22%), Positives = 104/261 (39%), Gaps = 26/261 (9%) Query: 19 RRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSR 78 + R+ L H + ++ ++ R ++S D I L++ Sbjct: 448 GSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFS-LDNRQIVSASRDRTIKLWN------ 500 Query: 79 QSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHD-TGMFTSSSFDKTLKVWDTNTLQTADV 137 + CK S G + HR V V++ P+ S+S+DKT+KVW+ + + Sbjct: 501 -TLGECKYTISEG---GEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLRST 556 Query: 138 FNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPR 197 VS L A G + V L DL G + L+ + I A+ +SP Sbjct: 557 LAGHTG--YVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEANS-VIHALCFSPN 613 Query: 198 YDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNG------KVNGL 251 ++ A+ + +K+WD+ S I D K++A ++ N+ L Sbjct: 614 RYWL--CAATEHGIKIWDLESKS---IVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSL 668 Query: 252 CFTSDGLHLLTVGTDNRMRLW 272 +++DG L + TD +R+W Sbjct: 669 NWSADGSTLFSGYTDGVIRVW 689 Score = 131 bits (330), Expect = 4e-31, Method: Composition-based stats. Identities = 41/248 (16%), Positives = 84/248 (33%), Gaps = 24/248 (9%) Query: 154 TKHCLVAVGTRGPKVQLCDLKS-----GSCSHILQGHRQEILAVSWSPRYDYILATASAD 208 ++ +R + L L G L GH + V S + L + S D Sbjct: 393 DNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQFAL-SGSWD 451 Query: 209 SRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNR 268 ++LWD+ H V + F+ D +++ D Sbjct: 452 GELRLWDLAAG----------------VSTRRFVGHTKDVLSVAFSLDNRQIVSASRDRT 495 Query: 269 MRLWNS-SNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQI 327 ++LWN+ + T+ G+ + ++F+ + V + T+ V+ + + + Sbjct: 496 IKLWNTLGECKYTISEGGEGHRDWVSCVRFSPN-TLQPTIVSASWDKTVKVWNLSNCKLR 554 Query: 328 TMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFED 387 + L GH V + SG +D +L W + + + + + L + Sbjct: 555 STLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEANSVIHALCFSPNR 614 Query: 388 AWSSSDEE 395 W + E Sbjct: 615 YWLCAATE 622 Score = 79.6 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 19/128 (14%), Positives = 43/128 (33%), Gaps = 1/128 (0%) Query: 235 QAVESANTAHNGKVNGLCF-TSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKK 293 ++ AH V + + +++ D + LW + + + Sbjct: 372 LVLKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSH 431 Query: 294 GLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGS 353 ++ V + + + ++ + +G GH K V F + +++ S S Sbjct: 432 FVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSAS 491 Query: 354 RDCNILAW 361 RD I W Sbjct: 492 RDRTIKLW 499 >3JAP-g nrPDB Length = 326 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 69/346 (19%), Positives = 128/346 (36%), Gaps = 52/346 (15%) Query: 36 RDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP 95 R H G + +L + ++SG D ++ + L + +Q ++ Sbjct: 11 RGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYK------- 63 Query: 96 DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF-NFEETVYSHHMSPVST 154 H + V+ V D S+S+DKTL++W+ T + F V S + S+ Sbjct: 64 -GHSHIVQDVVVSA-DGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSS 121 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSP---------RYDYILATA 205 K + +R +++ + G C+++L GH + V +P +A Sbjct: 122 K---IISASRDKTIRVWN-TVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSA 177 Query: 206 SADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGT 265 D V+ W + S +E+ HN +N + + DG + G Sbjct: 178 GMDKIVRSWSLNED--------------SYRIEADFIGHNNYINVVQPSPDGSLAASAGK 223 Query: 266 DNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGE 325 D ++ +WN L + N K F ++ S ++ S I +Y + + Sbjct: 224 DGQIYVWN-------LKHKSAFMNFDAKDEVFALAFSPSRFWLTAATASGIKIYDLENEV 276 Query: 326 QITMLK----GHYKTVD----CCVFQSNFQELYSGSRDCNILAWVP 363 I LK G+ K D + ++ Q L++G D I W Sbjct: 277 LIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQV 322 Score = 115 bits (287), Expect = 4e-26, Method: Composition-based stats. Identities = 45/266 (16%), Positives = 89/266 (33%), Gaps = 35/266 (13%) Query: 20 RAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQ 79 + T R+ L H G + ++ I+ ++S D I +++ Sbjct: 85 SWDKTLRLWNLATGNSEARFVGHTGDVLSVAID-ANSSKIISASRDKTIRVWNTVGDCAY 143 Query: 80 SYYTCKAVCSIGRDHPDVHRYSVETVQWYPHD---------TGMFTSSSFDKTLKVWDTN 130 H V V+ P + F S+ DK ++ W N Sbjct: 144 VLL--------------GHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLN 189 Query: 131 TLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEIL 190 +F ++ S L A + ++ + +LK S + E+ Sbjct: 190 EDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDA-KDEVF 248 Query: 191 AVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNG 250 A+++SP ++ TA+ S +K++D+ + + A + Sbjct: 249 ALAFSPSRFWL--TAATASGIKIYDLEN--------EVLIDELKPEFAGYTKAQDPHAVS 298 Query: 251 LCFTSDGLHLLTVGTDNRMRLWNSSN 276 L +++DG L TDN +R+W Sbjct: 299 LAWSADGQTLFAGYTDNVIRVWQVMT 324 Score = 81.1 bits (198), Expect = 9e-16, Method: Composition-based stats. Identities = 23/128 (17%), Positives = 43/128 (33%), Gaps = 1/128 (0%) Query: 235 QAVESANTAHNGKVNGLCFTSDGL-HLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKK 293 + HNG V L ++ L++ D + W + E + Sbjct: 8 LVLRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSH 67 Query: 294 GLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGS 353 ++ V + V + T+ ++ + +G GH V +N ++ S S Sbjct: 68 IVQDVVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISAS 127 Query: 354 RDCNILAW 361 RD I W Sbjct: 128 RDKTIRVW 135 >6G51-g nrPDB Length = 317 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 64/345 (18%), Positives = 125/345 (36%), Gaps = 49/345 (14%) Query: 36 RDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP 95 R + H G + + P +LS D I+++ L I + Sbjct: 8 RGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETN--------YGIPQRAL 59 Query: 96 DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF-NFEETVYSHHMSPVST 154 H + V V D S S+D TL++WD T T F + V S S + Sbjct: 60 RGHSHFVSDVVISS-DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQ--GHRQEILAVSWSPRYDY-ILATASADSRV 211 + + G+R ++L + G C + +Q H + + V +SP I+ + D V Sbjct: 119 Q---IVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 Query: 212 KLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL 271 K+W++ +++ + H G +N + + DG + G D + L Sbjct: 175 KVWNLAN----------------CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML 218 Query: 272 WNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLK 331 W+ + G++ Y + L F+ + ++ G +I ++ + + LK Sbjct: 219 WDLNEGKHL---YTLDGGDIINALCFS----PNRYWLCAATGPSIKIWDLEGKIIVDELK 271 Query: 332 ---------GHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYE 367 + ++ Q L++G D + W ++ Sbjct: 272 QEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 Score = 151 bits (380), Expect = 5e-37, Method: Composition-based stats. Identities = 55/260 (21%), Positives = 104/260 (40%), Gaps = 26/260 (10%) Query: 19 RRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSR 78 + T R+ L H + ++ + R ++SG D I L++ Sbjct: 81 GSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS-SDNRQIVSGSRDKTIKLWN------ 133 Query: 79 QSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG-MFTSSSFDKTLKVWDTNTLQTADV 137 + CK + H V V++ P+ + + S +DK +KVW+ + Sbjct: 134 -TLGVCKYTVQ-----DESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK-LKT 186 Query: 138 FNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPR 197 + T Y + ++ VS L A G + + L DL G + L G I A+ +SP Sbjct: 187 NHIGHTGYLNTVT-VSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPN 244 Query: 198 YDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDG 257 ++ A+ +K+WD+ + K + + +++ A + L +++DG Sbjct: 245 RYWL--CAATGPSIKIWDLEGKI-------IVDELKQEVISTSSKAEPPQCTSLAWSADG 295 Query: 258 LHLLTVGTDNRMRLWNSSNG 277 L TDN +R+W + G Sbjct: 296 QTLFAGYTDNLVRVWQVTIG 315 Score = 107 bits (267), Expect = 9e-24, Method: Composition-based stats. Identities = 35/192 (18%), Positives = 70/192 (36%), Gaps = 21/192 (10%) Query: 174 KSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKK 233 + + L+GH + ++ +P++ ++ +AS D + +W + + Sbjct: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKL-----------TRDETN 51 Query: 234 SQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKK 293 + A H+ V+ + +SDG L+ D +RLW+ + G T G K Sbjct: 52 YGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHT-----K 106 Query: 294 GLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITML--KGHYKTVDCCVFQSN--FQEL 349 + + + V TI ++ G + + H + V C F N + Sbjct: 107 DVLSVAFSSDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPII 165 Query: 350 YSGSRDCNILAW 361 S D + W Sbjct: 166 VSCGWDKLVKVW 177 Score = 88.1 bits (216), Expect = 6e-18, Method: Composition-based stats. Identities = 27/147 (18%), Positives = 51/147 (34%), Gaps = 1/147 (0%) Query: 233 KSQAVESANTAHNGKVNGLCFTSDGL-HLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNS 291 + + HNG V + T +L+ D + +W + E + Sbjct: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 Query: 292 KKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYS 351 + V + + T+ ++ + +G GH K V F S+ +++ S Sbjct: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122 Query: 352 GSRDCNILAWVPSLYEPVPDDDETTTK 378 GSRD I W DE+ ++ Sbjct: 123 GSRDKTIKLWNTLGVCKYTVQDESHSE 149 >6MZM-G nrPDB Length = 800 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 58/234 (24%), Positives = 93/234 (39%), Gaps = 34/234 (14%) Query: 41 IHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRY 100 H G + P + Y+LS DG + L+ L+ + Y H Y Sbjct: 541 GHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFTCLVGYKG-------------HNY 586 Query: 101 SVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVA 160 V Q+ P+ F S D+ ++W T+ Q +F + + + VA Sbjct: 587 PVWDTQFSPYGY-YFVSGGHDRVARLWATDHYQPLRIFAGH--LADVNCTRFHPNSNYVA 643 Query: 161 VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRAS 220 G+ V+L D+ +G+C I GH+ I ++++SP LAT + D RV LWD+ Sbjct: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR-FLATGATDGRVLLWDIGHG- 701 Query: 221 GCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 + H V L F+ DG L + DN +RLW++ Sbjct: 702 ---------------LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA 740 Score = 158 bits (400), Expect = 3e-39, Method: Composition-based stats. Identities = 51/247 (20%), Positives = 82/247 (33%), Gaps = 26/247 (10%) Query: 137 VFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSP 196 ++ VY SP + + V+L L++ +C +GH + +SP Sbjct: 539 LYGHSGPVYGASFSP---DRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595 Query: 197 RYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD 256 Y Y + D +LW I H VN F + Sbjct: 596 -YGYYFVSGGHDRVARLWATDHYQPLRI----------------FAGHLADVNCTRFHPN 638 Query: 257 GLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTI 316 ++ T D +RLW+ NG + G K + + Sbjct: 639 SNYVATGSADRTVRLWDVLNGNCVRIFTGH-----KGPIHSLTFSPNGRFLATGATDGRV 693 Query: 317 AVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW-VPSLYEPVPDDDET 375 ++ + G + LKGH TV F + + L SGS D + W +E + DD T Sbjct: 694 LLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFT 753 Query: 376 TTKSQLN 382 T +N Sbjct: 754 TATGHIN 760 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 54/255 (21%), Positives = 94/255 (36%), Gaps = 28/255 (10%) Query: 20 RAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQ 79 + T R+ L+ + H + P G Y +SGG D V L+ ++ Sbjct: 562 SEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY-GYYFVSGGHDRVARLWATDHYQPL 620 Query: 80 SYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN 139 + H V +++P ++ + S D+T+++WD +F Sbjct: 621 RIFAG-------------HLADVNCTRFHP-NSNYVATGSADRTVRLWDVLNGNCVRIFT 666 Query: 140 -FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRY 198 + ++S SP +A G +V L D+ G L+GH + ++ +S Sbjct: 667 GHKGPIHSLTFSP---NGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDG 723 Query: 199 DYILATASADSRVKLWDVRRASGCLITLDQHN--------GKKSQAVESANTAHNGKVNG 250 + ILA+ S D+ V+LWD +A L T D + + + V Sbjct: 724 E-ILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVH 782 Query: 251 LCFTSDGLHLLTVGT 265 L FT L L Sbjct: 783 LHFTRRNLVLAAGAY 797 Score = 145 bits (364), Expect = 4e-35, Method: Composition-based stats. Identities = 38/182 (20%), Positives = 70/182 (38%), Gaps = 22/182 (12%) Query: 180 HILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVES 239 IL GH + S+SP +Y+L++ S D V+LW ++ Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSS-SEDGTVRLWSLQTF----------------TCLV 579 Query: 240 ANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTV 299 HN V F+ G + ++ G D RLW + + + + G + + + Sbjct: 580 GYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFH--- 636 Query: 300 SCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNIL 359 S+ T+ ++ V +G + + GH + F N + L +G+ D +L Sbjct: 637 --PNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVL 694 Query: 360 AW 361 W Sbjct: 695 LW 696 Score = 79.2 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 24/113 (21%), Positives = 50/113 (44%), Gaps = 15/113 (13%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 + A+ T R+ + + H G I++L P GR++ +G +DG ++L+D+ + Sbjct: 642 VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGH 700 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWD 128 + H +V ++++ D + S S D T+++WD Sbjct: 701 G-------------LMVGELKGHTDTVCSLRFS-RDGEILASGSMDNTVRLWD 739 Score = 56.9 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 13/84 (15%), Positives = 26/84 (30%) Query: 286 KVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSN 345 K+ + + + T+ ++++ + + KGH V F Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596 Query: 346 FQELYSGSRDCNILAWVPSLYEPV 369 SG D W Y+P+ Sbjct: 597 GYYFVSGGHDRVARLWATDHYQPL 620 >4V7E-Bg nrPDB Length = 380 Score = 187 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 65/347 (18%), Positives = 122/347 (35%), Gaps = 47/347 (13%) Query: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 + H G + +LD P E +++S DG +++++ S + H Sbjct: 63 QGHSGKVYSLDWTP-EKNWIVSASQDGRLIVWNALTSQKTHAIKL-------------HC 108 Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ------TADVFNFEETVYSHHMSPVS 153 V + P+ + D +++ ++ Y+ V Sbjct: 109 PWVMECAFAPNGQSV-ACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVP 167 Query: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHIL-----QGHRQEILAVSWSPRYDYILATASAD 208 + + G+ L D+ +G I GH ++L++S + + + S D Sbjct: 168 DQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCD 227 Query: 209 SRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNR 268 + V+LWD+R S + T H G +N + F DG T D Sbjct: 228 TTVRLWDLRITSRAVRT---------------YHGHEGDINSVKFFPDGQRFGTGSDDGT 272 Query: 269 MRLWNSSNGENTLV-NYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGST-IAVYTVYSGEQ 326 RL++ G V N N+++ + +V+ S +F Y + V+ E Sbjct: 273 CRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEM 332 Query: 327 ITML----KGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPV 369 + L H + C S+ L +GS D N+ W S + + Sbjct: 333 VLNLGTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIWAFSGHRKI 379 Score = 130 bits (325), Expect = 1e-30, Method: Composition-based stats. Identities = 54/323 (16%), Positives = 106/323 (32%), Gaps = 32/323 (9%) Query: 20 RAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQ 79 + V ++ ++H + P G+ + GG D +++L + Sbjct: 85 SQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAP-NGQSVACGGLDSACSIFNLSSQ--- 140 Query: 80 SYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN 139 + H+ + Q+ P + S D+T +WD T Q +F Sbjct: 141 ---ADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFG 197 Query: 140 FE----ETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLK-SGSCSHILQGHRQEILAVSW 194 E T +S S + G+ V+L DL+ + GH +I +V + Sbjct: 198 SEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKF 257 Query: 195 SPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFT 254 P T S D +L+D+R + + + ++ V + F+ Sbjct: 258 FPDGQ-RFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPI---------VTSVAFS 307 Query: 255 SDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGS 314 G L ++ +W++ E L N G + N+ + + S + Sbjct: 308 ISGRLLFAGYSNGDCYVWDTLLAEMVL-NLGTLQNSHEGRISCLGLSSDGSALCTGSWDK 366 Query: 315 TIAVYTVYSGEQITMLKGHYKTV 337 + ++ GH K V Sbjct: 367 NLKIW---------AFSGHRKIV 380 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 42/216 (19%), Positives = 71/216 (32%), Gaps = 28/216 (12%) Query: 13 EDPLRLRRAESTRRVLGLELNKD-----RDVERIHGGGINTLDIEPVEGRYMLSGGSDGV 67 E L + T + + + + H + +L I + +SG D Sbjct: 170 ETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTT 229 Query: 68 IVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVW 127 + L+DL +SR H + +V+++P D F + S D T +++ Sbjct: 230 VRLWDLRITSR------------AVRTYHGHEGDINSVKFFP-DGQRFGTGSDDGTCRLF 276 Query: 128 DTNTLQTADVFNFEETVYSHHMSPV-----STKHCLVAVGTRGPKVQLCDLKSGSCSHIL 182 D T V+N E + + V S L+ G + D L Sbjct: 277 DMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNL 336 Query: 183 ----QGHRQEILAVSWSPRYDYILATASADSRVKLW 214 H I + S L T S D +K+W Sbjct: 337 GTLQNSHEGRISCLGLSSDGSA-LCTGSWDKNLKIW 371 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 42/263 (15%), Positives = 90/263 (34%), Gaps = 43/263 (16%) Query: 165 GPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD--------- 215 G + C LQGH ++ ++ W+P ++I+ +AS D R+ +W+ Sbjct: 45 GRTAVSFNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIV-SASQDGRLIVWNALTSQKTHA 103 Query: 216 ------------------------VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGL 251 + A Q + + V T H G + Sbjct: 104 IKLHCPWVMECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSC 163 Query: 252 CFTSD-GLHLLTVGTDNRMRLWNSSNGENTLVNYGKV-CNNSKKGLKFTVSCGCSSEFVF 309 + D L+T D LW+ + G+ + + ++ L +++ ++ F+ Sbjct: 164 QYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFIS 223 Query: 310 VPYGSTIAVYTVY-SGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW------V 362 +T+ ++ + + + GH ++ F + Q +GS D + Sbjct: 224 GSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQ 283 Query: 363 PSLYEPVPDDDETTTKSQLNPAF 385 +Y PD ++ + AF Sbjct: 284 LQVYNREPDRNDNELPIVTSVAF 306 Score = 69.9 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 27/163 (16%), Positives = 53/163 (32%), Gaps = 13/163 (7%) Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 DV + S H+GKV L +T + +++ D R+ +WN+ Sbjct: 36 DVEKYSKAQGRTAVSFNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNA 95 Query: 275 SNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGE-------QI 327 + T + K+ F + S +++ + S Sbjct: 96 LTSQKT--HAIKLHCPWVMECAFAPN---GQSVACGGLDSACSIFNLSSQADRDGNMPVS 150 Query: 328 TMLKGHYKTVDCCVFQSN-FQELYSGSRDCNILAWVPSLYEPV 369 +L GH C + + L +GS D + W + + + Sbjct: 151 RVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRI 193 >5NZU-C nrPDB Length = 905 Score = 187 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 51/302 (16%), Positives = 98/302 (32%), Gaps = 32/302 (10%) Query: 96 DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTK 155 V++V +P + M S ++ ++ VW+ T F E + + Sbjct: 12 TARSDRVKSVDLHPTEPWMLASL-YNGSVCVWNHETQTLVKTF--EVCDLPVRAAKFVAR 68 Query: 156 HCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 V G ++++ + + H+ + H I ++ P +IL + S D +KLWD Sbjct: 69 KNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTS-SDDMLIKLWD 127 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS-DGLHLLTVGTDNRMRLWNS 274 + C + H V + D + D +++W Sbjct: 128 WDKKWSCSQVFE---------------GHTHYVMQIVINPKDNNQFASASLDRTIKVWQL 172 Query: 275 SNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHY 334 + G + + S G + + ++ + + L+GH Sbjct: 173 GSSSPNFTLEG--HEKGVNCIDY-YSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHA 229 Query: 335 KTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDE 394 + V C F + +GS D + W S Y +S LN E W + Sbjct: 230 QNVSCASFHPELPIIITGSEDGTVRIWHSSTYR---------LESTLNYGMERVWCVASL 280 Query: 395 EG 396 G Sbjct: 281 RG 282 Score = 151 bits (381), Expect = 4e-37, Method: Composition-based stats. Identities = 51/319 (15%), Positives = 112/319 (35%), Gaps = 41/319 (12%) Query: 43 GGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSV 102 + ++D+ P E +ML+ +G + +++ E Q+ VC + V Sbjct: 15 SDRVKSVDLHPTEP-WMLASLYNGSVCVWNHET---QTLVKTFEVCDL----------PV 60 Query: 103 ETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVG 162 ++ + + + D ++V++ NTL+ +F V + Sbjct: 61 RAAKFVARKNWV-VTGADDMQIRVFNYNTLERVHMFEAHSD--YIRCIAVHPTQPFILTS 117 Query: 163 TRGPKVQLCDL-KSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASG 221 + ++L D K SCS + +GH ++ + +P+ + A+AS D +K+W + +S Sbjct: 118 SDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSP 177 Query: 222 CLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS--DGLHLLTVGTDNRMRLWNSSNGEN 279 H VN + + S D +L++ D +++W+ N Sbjct: 178 NFT----------------LEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTC 221 Query: 280 TLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDC 339 G + F + T+ ++ + + L + V C Sbjct: 222 VQTLEG--HAQNVSCASFHPELPI---IITGSEDGTVRIWHSSTYRLESTLNYGMERVWC 276 Query: 340 CVFQSNFQELYSGSRDCNI 358 + G + +I Sbjct: 277 VASLRGSNNVALGYDEGSI 295 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 45/210 (21%), Positives = 84/210 (40%), Gaps = 16/210 (7%) Query: 6 SARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSD 65 +A+ ++ + + RV + + H I + + P + ++L+ D Sbjct: 62 AAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQP-FILTSSDD 120 Query: 66 GVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLK 125 +I L+D + ++C V + H + V + P D F S+S D+T+K Sbjct: 121 MLIKLWDWDK-----KWSCSQVF-------EGHTHYVMQIVINPKDNNQFASASLDRTIK 168 Query: 126 VWDTNTLQTADVF-NFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQG 184 VW + E+ V K L+ G V++ D ++ +C L+G Sbjct: 169 VWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLI-SGADDRLVKIWDYQNKTCVQTLEG 227 Query: 185 HRQEILAVSWSPRYDYILATASADSRVKLW 214 H Q + S+ P I+ T S D V++W Sbjct: 228 HAQNVSCASFHPELP-IIITGSEDGTVRIW 256 Score = 131 bits (330), Expect = 4e-31, Method: Composition-based stats. Identities = 48/312 (15%), Positives = 102/312 (32%), Gaps = 38/312 (12%) Query: 27 VLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKA 86 V E + + + ++++G D I +++ R + Sbjct: 41 VWNHETQTLVKTFEVCDLPVRAAKFVARK-NWVVTGADDMQIRVFNYNTLERVHMF---- 95 Query: 87 VCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYS 146 + H + + +P +SS D +K+WD + + T Y Sbjct: 96 ---------EAHSDYIRCIAVHPTQ-PFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYV 145 Query: 147 HHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDY-ILATA 205 + + A + +++ L S S + L+GH + + + + D L + Sbjct: 146 MQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISG 205 Query: 206 SADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGT 265 + D VK+WD + + C+ TL+ H V+ F + ++T Sbjct: 206 ADDRLVKIWDYQNKT-CVQTLE---------------GHAQNVSCASFHPELPIIITGSE 249 Query: 266 DNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGE 325 D +R+W+SS N + + S S+ Y + + E Sbjct: 250 DGTVRIWHSSTYR-----LESTLNYGMERVWCVASLRGSNNVAL-GYDEGSIIVKLGREE 303 Query: 326 QITMLKGHYKTV 337 + + K + Sbjct: 304 PAMSMDANGKII 315 Score = 98.5 bits (243), Expect = 5e-21, Method: Composition-based stats. Identities = 47/300 (15%), Positives = 86/300 (28%), Gaps = 34/300 (11%) Query: 15 PLRLRRAESTR-RVLGLELN-KDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYD 72 P L ++ ++ + V H + + I P + S D I ++ Sbjct: 112 PFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQ 171 Query: 73 LENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYP-HDTGMFTSSSFDKTLKVWDTNT 131 L +SS + H V + +Y D S + D+ +K+WD Sbjct: 172 LGSSS-------------PNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQN 218 Query: 132 LQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILA 191 + + + ++ G+ V++ + L + + Sbjct: 219 KTCVQTLEGH--AQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWC 276 Query: 192 VSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGL 251 V+ S R +A + + V+ NGK A S N K G Sbjct: 277 VA-SLRGSNNVALGYDEGSII---VKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGD 332 Query: 252 CFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVP 311 DG L D G + N + + F V CG ++ Sbjct: 333 TEIKDGERLPLAVKD---------MGSCEIYPQTIQHNPNGR---FVVVCGDGEYIIYTA 380 >5FL8-q nrPDB Length = 515 Score = 187 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 71/376 (18%), Positives = 129/376 (34%), Gaps = 55/376 (14%) Query: 18 LRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSS 77 ++T R+ + + H + + P +G + +G D I L+D ++ Sbjct: 161 TGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSP-DGEVIATGSMDNTIRLWDPKSG- 218 Query: 78 RQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHD------TGMFTSSSFDKTLKVWDTNT 131 D H + ++ W P SSS D T+K+WDT + Sbjct: 219 -----------QCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVS 267 Query: 132 LQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKS-GSCSHILQGHRQEIL 190 + S L+ G+ V++ D+ S G C +IL+ H + Sbjct: 268 RVCQYTMSGHTNSVSC---VKWGGQGLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVN 324 Query: 191 AVSWSPRYDYILATASADSRVK-------------------------LWDVRRASGCLIT 225 +S S DY L + D K ++ + T Sbjct: 325 HLSLST--DYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYT 382 Query: 226 LDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYG 285 + N KS + T H VN + F+ DG ++++ DN ++LW+ +G+ G Sbjct: 383 MFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRG 442 Query: 286 KVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSN 345 V + V +T+ V+ V + + L GH V + + Sbjct: 443 HVA-----SVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSVD 497 Query: 346 FQELYSGSRDCNILAW 361 + + SG +D + W Sbjct: 498 GKRVCSGGKDKMVRLW 513 Score = 76.1 bits (185), Expect = 2e-14, Method: Composition-based stats. Identities = 19/94 (20%), Positives = 36/94 (38%) Query: 278 ENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTV 337 + + + + L + SS V +T ++ + + LKGHY V Sbjct: 130 KPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWV 189 Query: 338 DCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPD 371 C + + + + +GS D I W P + + D Sbjct: 190 LCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGD 223 >6HHQ-h nrPDB Length = 319 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 62/341 (18%), Positives = 124/341 (36%), Gaps = 48/341 (14%) Query: 36 RDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP 95 R H G + +L + +LS D ++ + L ++ ++ Sbjct: 10 RGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFK------- 62 Query: 96 DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTK 155 H + V+ D S+S+DKTL++WD T +T F ++ + K Sbjct: 63 -GHSHIVQDCTL-TADGAYALSASWDKTLRLWDVATGETYQRFVGHKS--DVMSVDIDKK 118 Query: 156 HCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSP-----RYDYILATASADSR 210 ++ G+R +++ +K G C L GH + V P + +A D Sbjct: 119 ASMIISGSRDKTIKVWTIK-GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKM 177 Query: 211 VKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMR 270 VK W++ + +E+ HN +N L + DG + + G D + Sbjct: 178 VKAWNLNQFQ----------------IEADFIGHNSNINTLTASPDGTLIASAGKDGEIM 221 Query: 271 LWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQIT-- 328 LWN + + S + F+++ + ++ + I V+++ + Sbjct: 222 LWNLAAKKAMYTL-------SAQDEVFSLAFSPNRYWLAAATATGIKVFSLDPQYLVDDL 274 Query: 329 --MLKGHYKTVD----CCVFQSNFQELYSGSRDCNILAWVP 363 G+ K + + ++ Q L++G D I W Sbjct: 275 RPEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQV 315 Score = 119 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 44/263 (16%), Positives = 93/263 (35%), Gaps = 35/263 (13%) Query: 20 RAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQ 79 + T R+ + + H + ++DI+ + ++SG D I ++ ++ Sbjct: 84 SWDKTLRLWDVATGETYQRFVGHKSDVMSVDID-KKASMIISGSRDKTIKVWTIKGQCLA 142 Query: 80 SYYTCKAVCSIGRDHPDVHRYSVETVQWYPH-----DTGMFTSSSFDKTLKVWDTNTLQT 134 + H V V+ P+ D+ S+ DK +K W+ N Q Sbjct: 143 TLL--------------GHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQI 188 Query: 135 ADVF-NFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVS 193 F + + SP L+A + ++ L +L + + L E+ +++ Sbjct: 189 EADFIGHNSNINTLTASP---DGTLIASAGKDGEIMLWNLAAKKAMYTLSAQ-DEVFSLA 244 Query: 194 WSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCF 253 +SP ++ A + +K++ + + A L + Sbjct: 245 FSPNRYWLAAATATG--IKVFSLD--------PQYLVDDLRPEFAGYSKAAEPHAVSLAW 294 Query: 254 TSDGLHLLTVGTDNRMRLWNSSN 276 ++DG L TDN +R+W Sbjct: 295 SADGQTLFAGYTDNVIRVWQVMT 317 Score = 101 bits (250), Expect = 7e-22, Method: Composition-based stats. Identities = 32/257 (12%), Positives = 75/257 (29%), Gaps = 28/257 (10%) Query: 141 EETVYSHHMSPVSTKHCLVAVGTRGPKVQLC-----DLKSGSCSHILQGHRQEILAVSWS 195 + ++ + + L+ +R + D K G +GH + + + Sbjct: 15 GHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDCTLT 74 Query: 196 PRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS 255 Y L +AS D ++LWDV H V + Sbjct: 75 ADGAYAL-SASWDKTLRLWDVATGETYQR----------------FVGHKSDVMSVDIDK 117 Query: 256 DGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSC---GCSSEFVFVPY 312 +++ D +++W + G+ G N+ ++ + S + Sbjct: 118 KASMIISGSRDKTIKVW-TIKGQCLATLLG--HNDWVSQVRVVPNEKADDDSVTIISAGN 174 Query: 313 GSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDD 372 + + + + GH ++ + + S +D I+ W + + + Sbjct: 175 DKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTL 234 Query: 373 DETTTKSQLNPAFEDAW 389 L + W Sbjct: 235 SAQDEVFSLAFSPNRYW 251 Score = 76.5 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 34/178 (19%), Positives = 54/178 (30%), Gaps = 20/178 (11%) Query: 233 KSQAVESANTAHNGKVNGLCFTSDGL-HLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNS 291 + + HNG V L ++ LL+ D + W + + + Sbjct: 5 EVLVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGH 64 Query: 292 KKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYS 351 ++ + + + T+ ++ V +GE GH V + S Sbjct: 65 SHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIIS 124 Query: 352 GSRDCNILAWV---------------PSLYEPVP----DDDETTTKSQLNPAFEDAWS 390 GSRD I W S VP DDD T S N AW+ Sbjct: 125 GSRDKTIKVWTIKGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWN 182 >1VYH-C nrPDB Length = 410 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 59/296 (19%), Positives = 101/296 (34%), Gaps = 39/296 (13%) Query: 89 SIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHH 148 + HR V V ++P + S+S D T+KVWD T S Sbjct: 98 PPEKYALSGHRSPVTRVIFHPV-FSVMVSASEDATIKVWDYETGDFERTLKGHTD--SVQ 154 Query: 149 MSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASAD 208 L+A + ++L D + C + GH + +VS P D+I+ +AS D Sbjct: 155 DISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIV-SASRD 213 Query: 209 SRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNR 268 +K+W+V + C+ T T H V + DG + + D Sbjct: 214 KTIKMWEV-QTGYCVKTF---------------TGHREWVRMVRPNQDGTLIASCSNDQT 257 Query: 269 MRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSS-----------------EFVFVP 311 +R+W + E + + + + SS + Sbjct: 258 VRVWVVATKECKAELRE--HRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGS 315 Query: 312 YGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYE 367 TI ++ V +G + L GH V +F S + + S + D + W Sbjct: 316 RDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKR 371 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 60/335 (17%), Positives = 119/335 (35%), Gaps = 31/335 (9%) Query: 34 KDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRD 93 ++ H + + PV M+S D I ++D E + Sbjct: 99 PEKYALSGHRSPVTRVIFHPVF-SVMVSASEDATIKVWDYETGDFERTLKG--------- 148 Query: 94 HPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADV-FNFEETVYSHHMSPV 152 H SV+ + + H + S S D T+K+WD + + V S + P Sbjct: 149 ----HTDSVQDISFD-HSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPN 203 Query: 153 STKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVK 212 + +R +++ ++++G C GHR+ + V + + ++A+ S D V+ Sbjct: 204 GDH---IVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPN-QDGTLIASCSNDQTVR 259 Query: 213 LWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD-----GLHLLTVGTDN 267 +W V C L +H + ++++ + G LL+ D Sbjct: 260 VW-VVATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDK 318 Query: 268 RMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQI 327 +++W+ S G + G +N +G+ F + T+ V+ + + Sbjct: 319 TIKMWDVSTGMCLMTLVG--HDNWVRGVLFH---SGGKFILSCADDKTLRVWDYKNKRCM 373 Query: 328 TMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWV 362 L H V F + +GS D + W Sbjct: 374 KTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Score = 177 bits (448), Expect = 8e-45, Method: Composition-based stats. Identities = 61/322 (18%), Positives = 106/322 (32%), Gaps = 57/322 (17%) Query: 20 RAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQ 79 ++T +V E + H + + + G+ + S +D I L+D + Sbjct: 127 SEDATIKVWDYETGDFERTLKGHTDSVQDISFD-HSGKLLASCSADMTIKLWDFQGFECI 185 Query: 80 SYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN 139 H ++V +V P + S+S DKT+K+W+ T F Sbjct: 186 RTMHG-------------HDHNVSSVSIMP-NGDHIVSASRDKTIKMWEVQTGYCVKTFT 231 Query: 140 FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYD 199 M + L+A + V++ + + C L+ HR + +SW+P Sbjct: 232 GHR--EWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHVVECISWAPESS 289 Query: 200 Y-------------------ILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA 240 Y L + S D +K+WDV CL+TL Sbjct: 290 YSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV-STGMCLMTL-------------- 334 Query: 241 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS 300 H+ V G+ F S G +L+ D +R+W+ N + T Sbjct: 335 -VGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTA- 392 Query: 301 CGCSSEFVFVPYGSTIAVYTVY 322 V T+ V+ Sbjct: 393 ----PYVVTGSVDQTVKVWECR 410 Score = 98.8 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 30/183 (16%), Positives = 52/183 (28%), Gaps = 19/183 (10%) Query: 227 DQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGK 286 D + A + H V + F +++ D +++W+ G+ + + Sbjct: 90 DPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGD-----FER 144 Query: 287 VCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNF 346 ++ TI ++ E I + GH V N Sbjct: 145 TLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNG 204 Query: 347 QELYSGSRDCNILAWVPSLYEPV--------------PDDDETTTKSQLNPAFEDAWSSS 392 + S SRD I W V P+ D T S N W + Sbjct: 205 DHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVA 264 Query: 393 DEE 395 +E Sbjct: 265 TKE 267 >4V8M-A7 nrPDB Length = 318 Score = 183 bits (463), Expect = 1e-46, Method: Composition-based stats. Identities = 59/337 (17%), Positives = 117/337 (34%), Gaps = 45/337 (13%) Query: 41 IHGGGINTLDI--EPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVH 98 H G + +L P ++S D ++ + ++ + + + H Sbjct: 11 GHRGWVTSLACPQTPETATKVVSTSRDKTLLSW----GPNPDRHSSECSYGLPDRRLEGH 66 Query: 99 RYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF-NFEETVYSHHMSPVSTKHC 157 V V ++ S+S+D +L++W+ Q F + V S SP + + Sbjct: 67 SAFVSDVALS-NNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQ-- 123 Query: 158 LVAVGTRGPKVQLCDLKSGSCSHILQ--GHRQEILAVSWSPRYD-YILATASADSRVKLW 214 + G R +++ ++K G C H L H + V +SP D ++ + D+ VK+W Sbjct: 124 -IVSGGRDNALRVWNVK-GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVW 181 Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 D+ + + H V + + DG + D RLW+ Sbjct: 182 DLATGR----------------LVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDL 225 Query: 275 SNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKG-H 333 + GE + + + ++ I ++ + + + I L H Sbjct: 226 TKGEAL-------SEMAAGAPINQICFSPNRYWMCAATEKGIRIFDLENKDIIVELAPEH 278 Query: 334 YKT------VDCCVFQSNFQELYSGSRDCNILAWVPS 364 + + ++ LYSG D I W S Sbjct: 279 QGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWGVS 315 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 46/257 (17%), Positives = 95/257 (36%), Gaps = 28/257 (10%) Query: 20 RAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQ 79 + + R+ L+ + + H + ++ P + R ++SGG D + +++++ Sbjct: 86 SWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSP-DNRQIVSGGRDNALRVWNVKGECMH 144 Query: 80 SYYTCKAVCSIGRDHPDVHRYSVETVQWYPH-DTGMFTSSSFDKTLKVWDTNTLQTADVF 138 + H V V++ P D + S +D +KVWD T + Sbjct: 145 TLSRG------------AHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDL 192 Query: 139 NFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRY 198 VS L A + +L DL G + I + +SP Sbjct: 193 KGHT--NYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAA-GAPINQICFSPNR 249 Query: 199 DYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGL 258 ++ A+ + ++++D+ + +H G K + + +++DG Sbjct: 250 YWM--CAATEKGIRIFDLENKDIIVELAPEHQGSKKIV---------PECVSIAWSADGS 298 Query: 259 HLLTVGTDNRMRLWNSS 275 L + TDN +R+W S Sbjct: 299 TLYSGYTDNVIRVWGVS 315 Score = 128 bits (320), Expect = 6e-30, Method: Composition-based stats. Identities = 48/266 (18%), Positives = 89/266 (33%), Gaps = 28/266 (10%) Query: 139 NFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLC----DLKSGSCSH-----ILQGHRQEI 189 V S V +R + D S CS+ L+GH + Sbjct: 11 GHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFV 70 Query: 190 LAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVN 249 V+ S +AS D ++LW+++ + H V Sbjct: 71 SDVALS-NNGNFAVSASWDHSLRLWNLQNGQ----------------CQYKFLGHTKDVL 113 Query: 250 GLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVF 309 + F+ D +++ G DN +R+WN GE + ++F+ S + V Sbjct: 114 SVAFSPDNRQIVSGGRDNALRVWNV-KGECMHTLSRGAHTDWVSCVRFSPSLD-APVIVS 171 Query: 310 VPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPV 369 + + + V+ + +G +T LKGH V + S +D W + E + Sbjct: 172 GGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEAL 231 Query: 370 PDDDETTTKSQLNPAFEDAWSSSDEE 395 + +Q+ + W + E Sbjct: 232 SEMAAGAPINQICFSPNRYWMCAATE 257 Score = 73.0 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 22/137 (16%), Positives = 45/137 (32%), Gaps = 7/137 (5%) Query: 236 AVESANTAHNGKVNGLCFTSD---GLHLLTVGTDNRMRLW----NSSNGENTLVNYGKVC 288 A E T H G V L +++ D + W + + E + + Sbjct: 4 AYEGQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRL 63 Query: 289 NNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQE 348 + + V + ++ ++ + +G+ GH K V F + ++ Sbjct: 64 EGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQ 123 Query: 349 LYSGSRDCNILAWVPSL 365 + SG RD + W Sbjct: 124 IVSGGRDNALRVWNVKG 140 >3C9C-A nrPDB Length = 432 Score = 182 bits (461), Expect = 2e-46, Method: Composition-based stats. Identities = 59/241 (24%), Positives = 98/241 (40%), Gaps = 16/241 (6%) Query: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 R H L P Y+LS D I L+D+ + ++ G H Sbjct: 180 RGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTG------HT 233 Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN----FEETVYSHHMSPVSTK 155 VE V W+ +F S + D+ L +WDT T+ + V +P S Sbjct: 234 AVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS-- 291 Query: 156 HCLVAVGTRGPKVQLCDLKSGS-CSHILQGHRQEILAVSWSPRYDYILATASADSRVKLW 214 ++A G+ V L DL++ H + H+ EI V WSP + ILA++ D R+ +W Sbjct: 292 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 351 Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLL-TVGTDNRMRLWN 273 D+ + T D +G + H K++ + + ++ +V DN M++W Sbjct: 352 DLSKIGEEQSTEDAEDGPPELLF--IHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 409 Query: 274 S 274 Sbjct: 410 M 410 Score = 125 bits (313), Expect = 3e-29, Method: Composition-based stats. Identities = 57/341 (16%), Positives = 116/341 (34%), Gaps = 62/341 (18%) Query: 35 DRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDH 94 + +++ H G +N P + + ++++D + + + + Sbjct: 122 EIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLR- 180 Query: 95 PDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVST 154 H+ + W P+ G S+S D T+ +WD N + +++ H + V Sbjct: 181 --GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 238 Query: 155 ------KHCLVAVGTRGPKVQLCDLKS---GSCSHILQGHRQEILAVSWSPRYDYILATA 205 L K+ + D ++ SH + H E+ +S++P ++ILAT Sbjct: 239 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATG 298 Query: 206 SADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS-DGLHLLTVG 264 SAD V LWD+R L + + H ++ + ++ + L + G Sbjct: 299 SADKTVALWDLRNLKLKLHSFES---------------HKDEIFQVQWSPHNETILASSG 343 Query: 265 TDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSG 324 TD R+ +W+ S + + E +F+ Sbjct: 344 TDRRLHVWDLSK--------------IGEEQSTEDAEDGPPELLFIHG------------ 377 Query: 325 EQITMLKGHYKTVDCCVFQSNFQELY-SGSRDCNILAWVPS 364 GH + + N + S S D + W + Sbjct: 378 -------GHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMA 411 Score = 98.5 bits (243), Expect = 4e-21, Method: Composition-based stats. Identities = 38/198 (19%), Positives = 67/198 (33%), Gaps = 45/198 (22%) Query: 22 ESTRRVLGLELN---KDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSR 78 + + N K H +N L P + +G +D + L+DL N Sbjct: 255 DQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL 314 Query: 79 QSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF 138 + + + H+ + VQW PH+ + SS D+ L VWD + + Sbjct: 315 KLHSF------------ESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQ-- 360 Query: 139 NFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRY 198 S + L G GH +I SW+P Sbjct: 361 -------STEDAEDGPPELLFIHG---------------------GHTAKISDFSWNPNE 392 Query: 199 DYILATASADSRVKLWDV 216 +I+ + S D+ +++W + Sbjct: 393 PWIICSVSEDNIMQVWQM 410 Score = 95.4 bits (235), Expect = 4e-20, Method: Composition-based stats. Identities = 44/296 (14%), Positives = 95/296 (32%), Gaps = 49/296 (16%) Query: 73 LENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTL 132 +N + I + H V ++ P + + + + + V+D Sbjct: 104 YDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTK- 162 Query: 133 QTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAV 192 + + S P DL+ L+GH++E + Sbjct: 163 ------HPSKPEPSGECQP--------------------DLR-------LRGHQKEGYGL 189 Query: 193 SWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLC 252 SW+P + L +AS D + LWD+ +D N T H V + Sbjct: 190 SWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKN---------IFTGHTAVVEDVA 240 Query: 253 FTSDGLHLL-TVGTDNRMRLWNSSNGENTLVNYG-KVCNNSKKGLKFTVSCGCSSEFVFV 310 + L +V D ++ +W++ N + ++ L F Sbjct: 241 WHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEF--ILATG 298 Query: 311 PYGSTIAVYTVYSGE-QITMLKGHYKTVDCCVFQSNFQELYSGS-RDCNILAWVPS 364 T+A++ + + + ++ + H + + + + + + S D + W S Sbjct: 299 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLS 354 >5G04-R nrPDB Length = 499 Score = 181 bits (458), Expect = 5e-46, Method: Composition-based stats. Identities = 73/339 (21%), Positives = 140/339 (41%), Gaps = 35/339 (10%) Query: 69 VLYDLENSSRQSYYTCKAVCSIGR---DHPDVHR-YSVETVQWYPHDTGMFTSSSFDKTL 124 VLY + + S TC+ + S+ D P++ Y + V W +G + + D ++ Sbjct: 150 VLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS---SGNVLAVALDNSV 206 Query: 125 KVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQG 184 +W ++ + E+ + +AVGT +VQL D++ + Sbjct: 207 YLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTS 266 Query: 185 HRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAH 244 H + ++SW+ YIL++ S + DVR A + TL + H Sbjct: 267 HSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATL---------------SGH 308 Query: 245 NGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCS 304 + +V GL + DG HL + G DN + +W S+ GE V + + +K C Sbjct: 309 SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPL-QTFTQHQGAVKAVAWCPWQ 367 Query: 305 SEFVFVPYGST---IAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYS--GSRDCNIL 359 S + G++ I ++ V SG ++ + H + V ++ +++EL S G ++ Sbjct: 368 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLV 426 Query: 360 AWVPSLYEPVPDDDETTTKS---QLNPAFEDAWSSSDEE 395 W V + T++ ++P S++ +E Sbjct: 427 IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADE 465 Score = 85.7 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 35/241 (14%), Positives = 87/241 (36%), Gaps = 53/241 (21%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPV--------------------- 54 L + + + ++ ++ K H + +L Sbjct: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH 300 Query: 55 -------------------EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP 95 +GR++ SGG+D ++ ++ ++ + + + Sbjct: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP--SAPGEGGW-------VPLQTF 351 Query: 96 DVHRYSVETVQWYPHDTGMFTS--SSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVS 153 H+ +V+ V W P + + + + D+ +++W+ + + V S SP Sbjct: 352 TQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSP-H 410 Query: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKL 213 K + G ++ + + + L+GH +L+++ SP +A+A+AD ++L Sbjct: 411 YKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGAT-VASAAADETLRL 469 Query: 214 W 214 W Sbjct: 470 W 470 Score = 55.3 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 32/200 (16%), Positives = 58/200 (29%), Gaps = 48/200 (24%) Query: 3 GFLSARQTGLEDPLRLRRAESTRRVLGLELNKD--------------------------- 35 G + + + + ++ V GL D Sbjct: 288 GHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVP 347 Query: 36 RDVERIHGGGINTLDIEPVEGRYMLSGGS--DGVIVLYDLENSSRQSYYTCKAVCSIGRD 93 H G + + P + + +GG D I ++++ C C D Sbjct: 348 LQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV----------CSGACLSAVD 397 Query: 94 HPDVHRYSVETVQWYPHDTGMFTSSSF-DKTLKVWDTNTL-QTADVFNFEETVYSHHMSP 151 V ++ W PH + + F L +W T+ + A++ V S MSP Sbjct: 398 AHSQ----VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP 453 Query: 152 VSTKHCLVAVGTRGPKVQLC 171 VA ++L Sbjct: 454 ---DGATVASAAADETLRLW 470 >5OPT-p nrPDB Length = 318 Score = 180 bits (457), Expect = 7e-46, Method: Composition-based stats. Identities = 58/340 (17%), Positives = 120/340 (35%), Gaps = 45/340 (13%) Query: 40 RIHGGGINTLDIEPVEGRYM--LSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDV 97 + H G + L + Y+ +S D ++ + ++ ++ C+ R + Sbjct: 10 KGHRGWVTALACPQITETYIKAVSTSRDNTLIAW--GSNMDRNSEECEYGFPERRL--EG 65 Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF-NFEETVYSHHMSPVSTKH 156 H V V ++ S+S+D +L++W+ T F + V S SP + + Sbjct: 66 HSAFVSDVALS-NNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQ- 123 Query: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQ--GHRQEILAVSWSPRYDY-ILATASADSRVKL 213 + G R +++ ++K G C H L H + V +SP + ++ + D+ VK+ Sbjct: 124 --IVSGGRDNALRVWNVK-GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKV 180 Query: 214 WDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 WD+ + + H + + + DG + D RLW+ Sbjct: 181 WDIASGR----------------LLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWD 224 Query: 274 SSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGH 333 + GE + + + ++ I ++ + + + I L Sbjct: 225 LTKGEAL-------SEMAAGAPINQICFSPNRYWMCAATEKGIRIFDLENKDVIVELAPE 277 Query: 334 -------YKTVDCCVFQSNFQELYSGSRDCNILAWVPSLY 366 + ++ LYSG D I W S + Sbjct: 278 AQQKSKKTPECMSIAWSADGNTLYSGYTDNVIRVWSVSEH 317 Score = 136 bits (342), Expect = 1e-32, Method: Composition-based stats. Identities = 45/257 (17%), Positives = 98/257 (38%), Gaps = 28/257 (10%) Query: 20 RAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQ 79 + + R+ L+ + H + ++ P + R ++SGG D + +++++ Sbjct: 86 SWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSP-DNRQIVSGGRDNALRVWNVKGECLH 144 Query: 80 SYYTCKAVCSIGRDHPDVHRYSVETVQWYPH-DTGMFTSSSFDKTLKVWDTNTLQTADVF 138 + H V V++ P +T + S +D +KVWD + + Sbjct: 145 TLGRG------------AHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDL 192 Query: 139 NFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRY 198 VS L A + +L DL G + I + +SP Sbjct: 193 KGHT--NYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAA-GAPINQICFSPNR 249 Query: 199 DYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGL 258 ++ A+ + ++++D+ ++ L +KS+ + + +++DG Sbjct: 250 YWM--CAATEKGIRIFDLENKD-VIVELAPEAQQKSK--------KTPECMSIAWSADGN 298 Query: 259 HLLTVGTDNRMRLWNSS 275 L + TDN +R+W+ S Sbjct: 299 TLYSGYTDNVIRVWSVS 315 Score = 126 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 46/269 (17%), Positives = 92/269 (34%), Gaps = 28/269 (10%) Query: 136 DVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLC----DLKSGSCSH-----ILQGHR 186 + V + ++ + +R + D S C + L+GH Sbjct: 8 QLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHS 67 Query: 187 QEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNG 246 + V+ S D +AS D ++LW+++ + H Sbjct: 68 AFVSDVALSNNGD-FAVSASWDHSLRLWNLQTG----------------VCQHKFLGHTK 110 Query: 247 KVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSE 306 V + F+ D +++ G DN +R+WN GE + ++F+ S + Sbjct: 111 DVLSVTFSPDNRQIVSGGRDNALRVWNV-KGECLHTLGRGAHTDWVSCVRFSPSL-ETPL 168 Query: 307 FVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLY 366 V + + + V+ + SG +T LKGH + + S +D W + Sbjct: 169 IVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKG 228 Query: 367 EPVPDDDETTTKSQLNPAFEDAWSSSDEE 395 E + + +Q+ + W + E Sbjct: 229 EALSEMAAGAPINQICFSPNRYWMCAATE 257 >4GGA-A nrPDB Length = 420 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 73/339 (21%), Positives = 140/339 (41%), Gaps = 35/339 (10%) Query: 69 VLYDLENSSRQSYYTCKAVCSIGR---DHPDVHR-YSVETVQWYPHDTGMFTSSSFDKTL 124 VLY + + S TC+ + S+ D P++ Y + V W +G + + D ++ Sbjct: 71 VLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS---SGNVLAVALDNSV 127 Query: 125 KVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQG 184 +W ++ + E+ + +AVGT +VQL D++ + Sbjct: 128 YLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTS 187 Query: 185 HRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAH 244 H + ++SW+ YIL++ S + DVR A + TL + H Sbjct: 188 HSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATL---------------SGH 229 Query: 245 NGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCS 304 + +V GL + DG HL + G DN + +W S+ GE V + + +K C Sbjct: 230 SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPL-QTFTQHQGAVKAVAWCPWQ 288 Query: 305 SEFVFVPYGST---IAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYS--GSRDCNIL 359 S + G++ I ++ V SG ++ + H + V ++ +++EL S G ++ Sbjct: 289 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLV 347 Query: 360 AWVPSLYEPVPDDDETTTKS---QLNPAFEDAWSSSDEE 395 W V + T++ ++P S++ +E Sbjct: 348 IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADE 386 Score = 84.2 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 35/241 (14%), Positives = 87/241 (36%), Gaps = 53/241 (21%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPV--------------------- 54 L + + + ++ ++ K H + +L Sbjct: 162 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH 221 Query: 55 -------------------EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP 95 +GR++ SGG+D ++ ++ ++ + + + Sbjct: 222 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP--SAPGEGGW-------VPLQTF 272 Query: 96 DVHRYSVETVQWYPHDTGMFTS--SSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVS 153 H+ +V+ V W P + + + + D+ +++W+ + + V S SP Sbjct: 273 TQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSP-H 331 Query: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKL 213 K + G ++ + + + L+GH +L+++ SP +A+A+AD ++L Sbjct: 332 YKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGAT-VASAAADETLRL 390 Query: 214 W 214 W Sbjct: 391 W 391 Score = 54.2 bits (128), Expect = 9e-08, Method: Composition-based stats. Identities = 32/200 (16%), Positives = 58/200 (29%), Gaps = 48/200 (24%) Query: 3 GFLSARQTGLEDPLRLRRAESTRRVLGLELNKD--------------------------- 35 G + + + + ++ V GL D Sbjct: 209 GHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVP 268 Query: 36 RDVERIHGGGINTLDIEPVEGRYMLSGGS--DGVIVLYDLENSSRQSYYTCKAVCSIGRD 93 H G + + P + + +GG D I ++++ C C D Sbjct: 269 LQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV----------CSGACLSAVD 318 Query: 94 HPDVHRYSVETVQWYPHDTGMFTSSSF-DKTLKVWDTNTL-QTADVFNFEETVYSHHMSP 151 V ++ W PH + + F L +W T+ + A++ V S MSP Sbjct: 319 AHSQ----VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP 374 Query: 152 VSTKHCLVAVGTRGPKVQLC 171 VA ++L Sbjct: 375 ---DGATVASAAADETLRLW 391 >6HQA-B nrPDB Length = 722 Score = 178 bits (450), Expect = 4e-45, Method: Composition-based stats. Identities = 55/253 (21%), Positives = 96/253 (37%), Gaps = 35/253 (13%) Query: 41 IHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRY 100 H G + +D P + RY++S D + L+ L+ YTC H Sbjct: 451 GHSGAVYGVDFSP-DNRYLISCSEDKTVRLWSLDT------YTCLVS-------YKGHSS 496 Query: 101 SVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVA 160 SV V++ P F ++S D+T ++W + + +F + + Sbjct: 497 SVWDVKFSPMG-HYFATASHDQTARLWSCDHIYPLRIFAGH--LNDVDCVEFHPNSTYLF 553 Query: 161 VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRAS 220 G+ ++ D+ G C + GH I ++ SP + LA+A DS V LWD+ Sbjct: 554 TGSSDKTARMWDIARGECVRVFMGHSGAINCLAVSPDGRW-LASAGEDSVVCLWDISTGR 612 Query: 221 GCLITLDQHNGKKSQAVESANTAH-NGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEN 279 A H + L F+ +G L++ G DN +R+W+ N Sbjct: 613 R----------------IKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVKKNTN 656 Query: 280 TLVNYGKVCNNSK 292 + + N+ Sbjct: 657 SPSAQPEPINDVT 669 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 56/286 (19%), Positives = 98/286 (34%), Gaps = 35/286 (12%) Query: 46 INTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYT--------CKAVCSIGRDHPDV 97 + L + + SG D I L+ ++ S +S V G Sbjct: 393 LTCLKFN-DDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLVG 451 Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTKH 156 H +V V + P D S S DKT+++W +T + +V+ SP+ Sbjct: 452 HSGAVYGVDFSP-DNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPM---G 507 Query: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 A + +L I GH ++ V + P Y+ T S+D ++WD+ Sbjct: 508 HYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLF-TGSSDKTARMWDI 566 Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN 276 R H+G +N L + DG L + G D+ + LW+ S Sbjct: 567 ARGE----------------CVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDIST 610 Query: 277 GENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVY 322 G G + + + + V +++ V+ V Sbjct: 611 GRRIKAMRG----HGRSSIYSLAFSREGTVLVSTGADNSVRVWDVK 652 Score = 147 bits (371), Expect = 6e-36, Method: Composition-based stats. Identities = 43/272 (15%), Positives = 84/272 (30%), Gaps = 43/272 (15%) Query: 137 VFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQ------------- 183 ++ F T + +VA G + ++L + +L+ Sbjct: 383 MYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVA 442 Query: 184 --------GHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQ 235 GH + V +SP Y++ + S D V+LW + + Sbjct: 443 VKGSRRLVGHSGAVYGVDFSPDNRYLI-SCSEDKTVRLWSLD----------------TY 485 Query: 236 AVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGL 295 + H+ V + F+ G + T D RLW+ + + G + + Sbjct: 486 TCLVSYKGHSSSVWDVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHL-----NDV 540 Query: 296 KFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRD 355 S+ T ++ + GE + + GH ++C + + L S D Sbjct: 541 DCVEFHPNSTYLFTGSSDKTARMWDIARGECVRVFMGHSGAINCLAVSPDGRWLASAGED 600 Query: 356 CNILAWVPSLYEPVPDDDETTTKSQLNPAFED 387 + W S + S + AF Sbjct: 601 SVVCLWDISTGRRIKAMRGHGRSSIYSLAFSR 632 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 41/197 (20%), Positives = 76/197 (38%), Gaps = 11/197 (5%) Query: 178 CSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD-----VRRASGCLITLDQHNGK 232 C + ++ + ++ ++A+ DS +KLW +R Q+N Sbjct: 382 CMYTFHNTNNDLTCLKFN-DDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDG 440 Query: 233 KSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSK 292 + H+G V G+ F+ D +L++ D +RLW+ + G ++S Sbjct: 441 VAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKG--HSSSV 498 Query: 293 KGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSG 352 +KF+ F + T +++ + + GH VDC F N L++G Sbjct: 499 WDVKFS---PMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTG 555 Query: 353 SRDCNILAWVPSLYEPV 369 S D W + E V Sbjct: 556 SSDKTARMWDIARGECV 572 Score = 129 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 41/200 (20%), Positives = 80/200 (40%), Gaps = 19/200 (9%) Query: 20 RAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQ 79 + T R+ L+ + H + + P+ G Y + D L+ ++ Sbjct: 472 SEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPM-GHYFATASHDQTARLWSCDH---- 526 Query: 80 SYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN 139 H V+ V+++P ++ + S DKT ++WD + VF Sbjct: 527 ---------IYPLRIFAGHLNDVDCVEFHP-NSTYLFTGSSDKTARMWDIARGECVRVFM 576 Query: 140 FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGH-RQEILAVSWSPRY 198 + + VS +A V L D+ +G ++GH R I ++++S R Sbjct: 577 GHSG--AINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRSSIYSLAFS-RE 633 Query: 199 DYILATASADSRVKLWDVRR 218 +L + AD+ V++WDV++ Sbjct: 634 GTVLVSTGADNSVRVWDVKK 653 Score = 91.1 bits (224), Expect = 7e-19, Method: Composition-based stats. Identities = 24/164 (14%), Positives = 54/164 (32%), Gaps = 16/164 (9%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 + T R+ + + H ++ ++ P Y+ +G SD ++D+ Sbjct: 510 FATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHP-NSTYLFTGSSDKTARMWDIAR 568 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 + H ++ + P D S+ D + +WD +T + Sbjct: 569 GECVRVFMG-------------HSGAINCLAVSP-DGRWLASAGEDSVVCLWDISTGRRI 614 Query: 136 DVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCS 179 + ++ LV+ G V++ D+K + S Sbjct: 615 KAMRGHGRSSIYSLAFSREGTVLVSTG-ADNSVRVWDVKKNTNS 657 >5Y1U-A nrPDB Length = 456 Score = 178 bits (450), Expect = 5e-45, Method: Composition-based stats. Identities = 60/250 (24%), Positives = 101/250 (40%), Gaps = 17/250 (6%) Query: 31 ELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSI 90 E N D + R H L P ++LS D I L+D+ ++ Sbjct: 197 ECNPDLRL-RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFT 255 Query: 91 GRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN----FEETVYS 146 G H VE V W+ +F S + D+ L +WDT + T+ + V Sbjct: 256 G------HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNC 309 Query: 147 HHMSPVSTKHCLVAVGTRGPKVQLCDLKSGS-CSHILQGHRQEILAVSWSPRYDYILATA 205 +P S ++A G+ V L DL++ H + H+ EI V WSP + ILA++ Sbjct: 310 LSFNPYS--EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 367 Query: 206 SADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLL-TVG 264 D R+ +WD+ + D +G + H K++ + + ++ +V Sbjct: 368 GTDRRLNVWDLSKIGEEQSPEDAEDGPPELLF--IHGGHTAKISDFSWNPNEPWVICSVS 425 Query: 265 TDNRMRLWNS 274 DN M++W Sbjct: 426 EDNIMQVWQM 435 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 61/400 (15%), Positives = 122/400 (30%), Gaps = 67/400 (16%) Query: 15 PLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLE 74 P R + L L E+ H I ++ + + ++ S + Sbjct: 82 PDVTRPEGKDFSIHRLVLGTHTSDEQNHL-VIASVQLPNDDAQFDAS----------HYD 130 Query: 75 NSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN---- 130 + + I + H V ++ P + + + + + V+D Sbjct: 131 SEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPS 190 Query: 131 ----TLQTADVF---NFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDL-------KSG 176 + + ++ Y +P + H L + + L D+ K Sbjct: 191 KPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLL--SASDDHTICLWDISAVPKEGKVV 248 Query: 177 SCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQA 236 I GH + VSW ++ + + + D ++ +WD R + + Sbjct: 249 DAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNN-------------TSK 295 Query: 237 VESANTAHNGKVNGLCFTSDGLH-LLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGL 295 + AH +VN L F L T D + LW+ N + L ++ S K Sbjct: 296 PSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFE-----SHKDE 350 Query: 296 KFTVSCGCSSEFVFVPYGSTIA--VYTVYS--------------GEQITMLKGHYKTVDC 339 F V +E + G+ V+ + E + + GH + Sbjct: 351 IFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISD 410 Query: 340 CVFQSNFQE-LYSGSRDCNILAWVPSLYEPVPDDDETTTK 378 + N + S S D + W + +D E + Sbjct: 411 FSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVD 450 Score = 99 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 58/389 (14%), Positives = 130/389 (33%), Gaps = 48/389 (12%) Query: 5 LSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGS 64 ++ ++ +D + R ++ D+ H L+ + +++ Sbjct: 32 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTH-----ALEWPSLTAQWLP---- 82 Query: 65 DGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFD--- 121 D+ + + + V +G D + V P+D F +S +D Sbjct: 83 -------DVTRPEGKDFSIHRLV--LGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEK 133 Query: 122 KTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLK------- 174 + + + + + + C++A T V + D Sbjct: 134 GEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPD 193 Query: 175 -SGSC--SHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNG 231 SG C L+GH++E +SW+P L +AS D + LWD+ +D Sbjct: 194 PSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDA--- 250 Query: 232 KKSQAVESANTAHNGKVNGLCFTSDGLHLL-TVGTDNRMRLWNSSNGENTLVNYG-KVCN 289 ++ T H V + + L +V D ++ +W++ + + ++ Sbjct: 251 ------KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHT 304 Query: 290 NSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGE-QITMLKGHYKTVDCCVFQSNFQE 348 L F T+A++ + + + ++ + H + + + + Sbjct: 305 AEVNCLSFNPYSEF--ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET 362 Query: 349 LYSGS-RDCNILAWVPS--LYEPVPDDDE 374 + + S D + W S E P+D E Sbjct: 363 ILASSGTDRRLNVWDLSKIGEEQSPEDAE 391 >5LCW-Q nrPDB Length = 374 Score = 177 bits (448), Expect = 8e-45, Method: Composition-based stats. Identities = 73/339 (21%), Positives = 140/339 (41%), Gaps = 35/339 (10%) Query: 69 VLYDLENSSRQSYYTCKAVCSIGR---DHPDVHR-YSVETVQWYPHDTGMFTSSSFDKTL 124 VLY + + S TC+ + S+ D P++ Y + V W +G + + D ++ Sbjct: 25 VLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS---SGNVLAVALDNSV 81 Query: 125 KVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQG 184 +W ++ + E+ + +AVGT +VQL D++ + Sbjct: 82 YLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTS 141 Query: 185 HRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAH 244 H + ++SW+ YIL++ S + DVR A + TL + H Sbjct: 142 HSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATL---------------SGH 183 Query: 245 NGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCS 304 + +V GL + DG HL + G DN + +W S+ GE V + + +K C Sbjct: 184 SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPL-QTFTQHQGAVKAVAWCPWQ 242 Query: 305 SEFVFVPYGST---IAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYS--GSRDCNIL 359 S + G++ I ++ V SG ++ + H + V ++ +++EL S G ++ Sbjct: 243 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLV 301 Query: 360 AWVPSLYEPVPDDDETTTKS---QLNPAFEDAWSSSDEE 395 W V + T++ ++P S++ +E Sbjct: 302 IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADE 340 Score = 83.4 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 35/241 (14%), Positives = 87/241 (36%), Gaps = 53/241 (21%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPV--------------------- 54 L + + + ++ ++ K H + +L Sbjct: 116 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH 175 Query: 55 -------------------EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP 95 +GR++ SGG+D ++ ++ ++ + + + Sbjct: 176 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP--SAPGEGGW-------VPLQTF 226 Query: 96 DVHRYSVETVQWYPHDTGMFTS--SSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVS 153 H+ +V+ V W P + + + + D+ +++W+ + + V S SP Sbjct: 227 TQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSP-H 285 Query: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKL 213 K + G ++ + + + L+GH +L+++ SP +A+A+AD ++L Sbjct: 286 YKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGAT-VASAAADETLRL 344 Query: 214 W 214 W Sbjct: 345 W 345 Score = 53.8 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 32/200 (16%), Positives = 58/200 (29%), Gaps = 48/200 (24%) Query: 3 GFLSARQTGLEDPLRLRRAESTRRVLGLELNKD--------------------------- 35 G + + + + ++ V GL D Sbjct: 163 GHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVP 222 Query: 36 RDVERIHGGGINTLDIEPVEGRYMLSGGS--DGVIVLYDLENSSRQSYYTCKAVCSIGRD 93 H G + + P + + +GG D I ++++ C C D Sbjct: 223 LQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV----------CSGACLSAVD 272 Query: 94 HPDVHRYSVETVQWYPHDTGMFTSSSF-DKTLKVWDTNTL-QTADVFNFEETVYSHHMSP 151 V ++ W PH + + F L +W T+ + A++ V S MSP Sbjct: 273 AHSQ----VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP 328 Query: 152 VSTKHCLVAVGTRGPKVQLC 171 VA ++L Sbjct: 329 ---DGATVASAAADETLRLW 345 >5WJC-A nrPDB Length = 430 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 59/244 (24%), Positives = 108/244 (44%), Gaps = 13/244 (5%) Query: 38 VERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDV 97 V + H L P + +G D VI L+D++ S S T K + I + H Sbjct: 177 VLKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSET-KVISPIAKYH--R 233 Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTAD----VFNFEETVYSHHMSPVS 153 H V VQ++P + S S D TL++ DT + + + + + ++P + Sbjct: 234 HTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFN 293 Query: 154 TKHCLVAVGTRGPKVQLCDLKS-GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVK 212 L+A + V L DL++ H L+GH E+ + WSP + ILA++S D RV Sbjct: 294 D--YLLATASADKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVC 351 Query: 213 LWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLL-TVGTDNRMRL 271 +WD+ + D +G + H +++ + + ++ ++ DN +++ Sbjct: 352 IWDLEKIGEEQTPEDAEDGSPELLF--MHGGHTNRISEFSWCPNERWVVGSLADDNILQI 409 Query: 272 WNSS 275 W+ S Sbjct: 410 WSPS 413 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 59/325 (18%), Positives = 111/325 (34%), Gaps = 25/325 (7%) Query: 72 DLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMF-TSSSFDKTLKVWDTN 130 D + Y + + D + + +VQ D + S + + + Sbjct: 61 DKKTIPGTDYSIQRLILGTHTSGNDQNYLQIASVQLPNFDEDTTEFTPSTIRRAQATGSY 120 Query: 131 TLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCD------LKSGS--CSHIL 182 T++ + + V P K ++A G + D L +G +L Sbjct: 121 TIEISQKIPHDGDVNRARYMP--QKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVL 178 Query: 183 QGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANT 242 +GH E + W+P LAT + D + LWDV+ S + K + + Sbjct: 179 KGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSF------TSSETKVISPIAKYH 232 Query: 243 AHNGKVNGLCFTSDGL-HLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSC 301 H VN + F L +V D +++ ++ N KV K + Sbjct: 233 RHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRL--NPEEEAPKVIQAHSKAINAVAIN 290 Query: 302 GCSSEFV-FVPYGSTIAVYTVYSG-EQITMLKGHYKTVDCCVFQS-NFQELYSGSRDCNI 358 + + T+A++ + + +++ L+GH V + + L S S D + Sbjct: 291 PFNDYLLATASADKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRV 350 Query: 359 LAWVPS--LYEPVPDDDETTTKSQL 381 W E P+D E + L Sbjct: 351 CIWDLEKIGEEQTPEDAEDGSPELL 375 Score = 73.4 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 21/115 (18%), Positives = 40/115 (34%), Gaps = 2/115 (1%) Query: 16 LRLRRAESTRRVLGLELNKDR-DVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLE 74 L A+ T + L R H + L+ P + + S +D + ++DLE Sbjct: 297 LATASADKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLE 356 Query: 75 N-SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWD 128 Q+ + H + W P++ + S + D L++W Sbjct: 357 KIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIWS 411 >5YZG-W nrPDB Length = 579 Score = 174 bits (440), Expect = 6e-44, Method: Composition-based stats. Identities = 55/329 (16%), Positives = 111/329 (33%), Gaps = 30/329 (9%) Query: 34 KDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRD 93 K V H G++ + + P+ G +LS D I L+++ R C Sbjct: 279 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERR-----CLRTFI---- 329 Query: 94 HPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVS 153 H +V + + T F S+++D+ LK+WDT T Q F + Y +P Sbjct: 330 ---GHSKAVRDICFNTAGT-QFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDE 385 Query: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKL 213 K L G K+ D++SG H + + + ++T S D +++ Sbjct: 386 DKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVST-SDDKSLRV 444 Query: 214 WDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 W + + + + H+ + + +G L DN++ ++ Sbjct: 445 W-------------EWDIPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFG 489 Query: 274 SSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGH 333 + N + S + + ++ + + + K H Sbjct: 490 AQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAH 549 Query: 334 YKTVDCCVFQSNF-QELYSGSRDCNILAW 361 K V+ + ++ + D I W Sbjct: 550 DKVCIGAVWHPHETSKVITCGWDGLIKLW 578 Score = 148 bits (374), Expect = 3e-36, Method: Composition-based stats. Identities = 42/187 (22%), Positives = 70/187 (37%), Gaps = 18/187 (9%) Query: 176 GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQ 235 H+ GH + + AV P ++L + S D ++KLW+V CL T Sbjct: 278 KKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTF--------- 328 Query: 236 AVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGL 295 H+ V +CF + G L+ D ++LW++ G+ + + Sbjct: 329 ------IGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNR---KVPYCV 379 Query: 296 KFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRD 355 KF + FV I + + SGE + H V+ VF + S S D Sbjct: 380 KFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDD 439 Query: 356 CNILAWV 362 ++ W Sbjct: 440 KSLRVWE 446 Score = 97.7 bits (241), Expect = 8e-21, Method: Composition-based stats. Identities = 46/267 (17%), Positives = 97/267 (36%), Gaps = 43/267 (16%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGI-NTLDIEPVEG--RYMLSGGSDGVIVLYD 72 + ++ E + + R + + P E ++G SD IV +D Sbjct: 347 FLSAAYDRYLKLWDTETGQC--ISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWD 404 Query: 73 LENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTL 132 + + Y D H +V T+ + + F S+S DK+L+VW+ + Sbjct: 405 IRSGEIVQEY-------------DRHLGAVNTIVFV-DENRRFVSTSDDKSLRVWEWDIP 450 Query: 133 QTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSG---SCSHILQGHR--Q 187 E +++S +S +A + ++ + ++ + I +GH Sbjct: 451 VDFKYI-AEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAG 509 Query: 188 EILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGK 247 V +SP Y++ + + ++ +WD K+ + S AH+ Sbjct: 510 YACQVDFSPDMSYVI-SGDGNGKLNIWD----------------WKTTKLYSRFKAHDKV 552 Query: 248 VNGLCFTSDGL-HLLTVGTDNRMRLWN 273 G + ++T G D ++LW+ Sbjct: 553 CIGAVWHPHETSKVITCGWDGLIKLWD 579 Score = 50.7 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 17/111 (15%), Positives = 35/111 (31%), Gaps = 4/111 (3%) Query: 265 TDNRMRLWNSSNGENTLVNYGKVC--NNSKKGLKFTVSCGCSS-EFVFVPYGSTIAVYTV 321 D + L ++ E + ++ + KG+ S + I ++ V Sbjct: 259 QDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV 318 Query: 322 Y-SGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPD 371 Y + GH K V F + + S + D + W + + Sbjct: 319 YGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISR 369 >6QDV-o nrPDB Length = 513 Score = 174 bits (440), Expect = 6e-44, Method: Composition-based stats. Identities = 55/329 (16%), Positives = 111/329 (33%), Gaps = 30/329 (9%) Query: 34 KDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRD 93 K V H G++ + + P+ G +LS D I L+++ R C Sbjct: 213 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERR-----CLRTFI---- 263 Query: 94 HPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVS 153 H +V + + T F S+++D+ LK+WDT T Q F + Y +P Sbjct: 264 ---GHSKAVRDICFNTAGT-QFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDE 319 Query: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKL 213 K L G K+ D++SG H + + + ++T S D +++ Sbjct: 320 DKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVST-SDDKSLRV 378 Query: 214 WDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 W + + + + H+ + + +G L DN++ ++ Sbjct: 379 W-------------EWDIPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFG 423 Query: 274 SSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGH 333 + N + S + + ++ + + + K H Sbjct: 424 AQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAH 483 Query: 334 YKTVDCCVFQSNF-QELYSGSRDCNILAW 361 K V+ + ++ + D I W Sbjct: 484 DKVCIGAVWHPHETSKVITCGWDGLIKLW 512 Score = 148 bits (374), Expect = 3e-36, Method: Composition-based stats. Identities = 42/187 (22%), Positives = 70/187 (37%), Gaps = 18/187 (9%) Query: 176 GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQ 235 H+ GH + + AV P ++L + S D ++KLW+V CL T Sbjct: 212 KKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTF--------- 262 Query: 236 AVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGL 295 H+ V +CF + G L+ D ++LW++ G+ + + Sbjct: 263 ------IGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNR---KVPYCV 313 Query: 296 KFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRD 355 KF + FV I + + SGE + H V+ VF + S S D Sbjct: 314 KFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDD 373 Query: 356 CNILAWV 362 ++ W Sbjct: 374 KSLRVWE 380 Score = 97.7 bits (241), Expect = 8e-21, Method: Composition-based stats. Identities = 46/267 (17%), Positives = 97/267 (36%), Gaps = 43/267 (16%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGI-NTLDIEPVEG--RYMLSGGSDGVIVLYD 72 + ++ E + + R + + P E ++G SD IV +D Sbjct: 281 FLSAAYDRYLKLWDTETGQC--ISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWD 338 Query: 73 LENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTL 132 + + Y D H +V T+ + + F S+S DK+L+VW+ + Sbjct: 339 IRSGEIVQEY-------------DRHLGAVNTIVFV-DENRRFVSTSDDKSLRVWEWDIP 384 Query: 133 QTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSG---SCSHILQGHR--Q 187 E +++S +S +A + ++ + ++ + I +GH Sbjct: 385 VDFKYI-AEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAG 443 Query: 188 EILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGK 247 V +SP Y++ + + ++ +WD K+ + S AH+ Sbjct: 444 YACQVDFSPDMSYVI-SGDGNGKLNIWD----------------WKTTKLYSRFKAHDKV 486 Query: 248 VNGLCFTSDGL-HLLTVGTDNRMRLWN 273 G + ++T G D ++LW+ Sbjct: 487 CIGAVWHPHETSKVITCGWDGLIKLWD 513 Score = 50.7 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 17/111 (15%), Positives = 35/111 (31%), Gaps = 4/111 (3%) Query: 265 TDNRMRLWNSSNGENTLVNYGKVC--NNSKKGLKFTVSCGCSS-EFVFVPYGSTIAVYTV 321 D + L ++ E + ++ + KG+ S + I ++ V Sbjct: 193 QDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV 252 Query: 322 Y-SGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPD 371 Y + GH K V F + + S + D + W + + Sbjct: 253 YGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISR 303 >3CFV-B nrPDB Length = 414 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 58/250 (23%), Positives = 100/250 (40%), Gaps = 17/250 (6%) Query: 31 ELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSI 90 E N D + R H L ++LS D + L+D+ ++ Sbjct: 168 ECNPDLRL-RGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFT 226 Query: 91 GRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN----FEETVYS 146 G H VE V W+ +F S + D+ L +WDT + T+ + V Sbjct: 227 G------HSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNC 280 Query: 147 HHMSPVSTKHCLVAVGTRGPKVQLCDLKSGS-CSHILQGHRQEILAVSWSPRYDYILATA 205 +P S ++A G+ V L DL++ H + H+ EI V WSP + ILA++ Sbjct: 281 LSFNPYS--EFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASS 338 Query: 206 SADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLL-TVG 264 D R+ +WD+ + D +G + H K++ + + ++ +V Sbjct: 339 GTDRRLNVWDLSKIGEEQSAEDAEDGPPELLF--IHGGHTAKISDFSWNPNEPWVICSVS 396 Query: 265 TDNRMRLWNS 274 DN M++W Sbjct: 397 EDNIMQIWQM 406 Score = 124 bits (311), Expect = 6e-29, Method: Composition-based stats. Identities = 58/339 (17%), Positives = 116/339 (34%), Gaps = 62/339 (18%) Query: 37 DVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPD 96 +++ H G +N P + + ++++D + + + + Sbjct: 120 EIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLR--- 176 Query: 97 VHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVST-- 154 H+ + W + +G S+S D T+ +WD N + +++ H + V Sbjct: 177 GHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVA 236 Query: 155 ----KHCLVAVGTRGPKVQLCDLKS---GSCSHILQGHRQEILAVSWSPRYDYILATASA 207 L K+ + D +S SH++ H E+ +S++P ++ILAT SA Sbjct: 237 WHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSA 296 Query: 208 DSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS-DGLHLLTVGTD 266 D V LWD+R L T + H ++ + ++ + L + GTD Sbjct: 297 DKTVALWDLRNLKLKLHTFES---------------HKDEIFQVHWSPHNETILASSGTD 341 Query: 267 NRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQ 326 R+ +W+ S + + E +F+ Sbjct: 342 RRLNVWDLSK--------------IGEEQSAEDAEDGPPELLFIHG-------------- 373 Query: 327 ITMLKGHYKTVDCCVFQSNFQE-LYSGSRDCNILAWVPS 364 GH + + N + S S D + W + Sbjct: 374 -----GHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMA 407 Score = 96.9 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 36/237 (15%), Positives = 82/237 (34%), Gaps = 35/237 (14%) Query: 3 GFLSARQTGLEDPLRLRRAESTRRVLGLELNKDR-------DVERIHGGGINTLDIEPVE 55 G+ + + L L + T + + + H + + + Sbjct: 182 GYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLH 241 Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMF 115 S D ++++D +++ D H V + + P+ + Sbjct: 242 ESLFGSVADDQKLMIWDTRSNTTSKPSHL----------VDAHTAEVNCLSFNPYSEFIL 291 Query: 116 TSSSFDKTLKVWDTNTLQ-TADVFN-FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDL 173 + S DKT+ +WD L+ F ++ ++ H SP + ++A ++ + DL Sbjct: 292 ATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNET--ILASSGTDRRLNVWDL 349 Query: 174 KS--------------GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 I GH +I SW+P +++ + S D+ +++W + Sbjct: 350 SKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 406 Score = 92.7 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 41/295 (13%), Positives = 96/295 (32%), Gaps = 49/295 (16%) Query: 74 ENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ 133 ++ + I + H V ++ P + + + + + V+D Sbjct: 101 DSDKGEFGGFGSVTGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTK-- 158 Query: 134 TADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVS 193 + + S +P DL+ L+GH++E +S Sbjct: 159 -----HPAKPDPSGECNP--------------------DLR-------LRGHQKEGYGLS 186 Query: 194 WSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCF 253 W+ L +AS D V LWD+ +D ++ T H+ V + + Sbjct: 187 WNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDA---------KAIFTGHSAVVEDVAW 237 Query: 254 TSDGLHLL-TVGTDNRMRLWNSSNGENTLVNY-GKVCNNSKKGLKFTVSCGCSSEFVFVP 311 L +V D ++ +W++ + + ++ L F Sbjct: 238 HLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEF--ILATGS 295 Query: 312 YGSTIAVYTVYSGE-QITMLKGHYKTVDCCVFQSNFQELYSGS-RDCNILAWVPS 364 T+A++ + + + ++ + H + + + + + + S D + W S Sbjct: 296 ADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLS 350 Score = 29.9 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 15/44 (34%), Gaps = 1/44 (2%) Query: 329 MLKGHYKTVDCCVFQSNFQ-ELYSGSRDCNILAWVPSLYEPVPD 371 L+GH K + SN L S S D + W + Sbjct: 174 RLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGK 217 >5Y88-O nrPDB Length = 451 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 73/358 (20%), Positives = 125/358 (34%), Gaps = 53/358 (14%) Query: 38 VERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDV 97 V H G + + I+PV+ + ++G +D + ++DL ++ + D Sbjct: 134 VINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSDR 193 Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHC 157 H S S DKT+K WD Q + + + Sbjct: 194 H--------------PYLFSVSEDKTVKCWDLEKNQIIRDYYGH--LSGVRTVSIHPTLD 237 Query: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 L+A R ++L D+++ L GH+ I V +P ++++ S D+ V+LWDV Sbjct: 238 LIATAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSS-STDATVRLWDV- 295 Query: 218 RASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNG 277 + T H V + + TD+ +R W + G Sbjct: 296 ---------------VAGKTMKVLTHHKRSVRATALHPKEFSVASACTDD-IRSWGLAEG 339 Query: 278 ENTLVNYGKVCNNSKKGLKFT-----VSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKG 332 + L N+ L + G + F Y S ++ + E + L+G Sbjct: 340 -SLLTNFESEKTGIINTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEG 398 Query: 333 HYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWS 390 ++V C F L +G D +I W DET TK P AW+ Sbjct: 399 -ERSVLCSTFDKTGLRLITGEADKSIKIW---------KQDETATKES-EPGL--AWN 443 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 29/192 (15%), Positives = 63/192 (32%), Gaps = 21/192 (10%) Query: 176 GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQ 235 S ++ GH + V+ P + T S D+ +K+WD+ Sbjct: 129 WKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGK--------------- 173 Query: 236 AVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGL 295 +++ H V + + +L +V D ++ W+ + YG + G+ Sbjct: 174 -LKTTLAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHL-----SGV 227 Query: 296 KFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRD 355 + S I ++ + + + L GH ++ ++ S S D Sbjct: 228 RTVSIHPTLDLIATAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTD 287 Query: 356 CNILAWVPSLYE 367 + W + Sbjct: 288 ATVRLWDVVAGK 299 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 56/296 (18%), Positives = 97/296 (32%), Gaps = 30/296 (10%) Query: 5 LSARQTGLEDP---LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLS 61 ++ R + D L + T + LE N+ H G+ T+ I P + + Sbjct: 183 MTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLD-LIAT 241 Query: 62 GGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFD 121 G D VI L+D+ I H+ + VQ P D + SSS D Sbjct: 242 AGRDSVIKLWDMRT-------------RIPVITLVGHKGPINQVQCTPVDPQV-VSSSTD 287 Query: 122 KTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHI 181 T+++WD +T V + S + + K VA ++ L GS Sbjct: 288 ATVRLWDVVAGKTMKVLTHHKR--SVRATALHPKEFSVASACTD-DIRSWGLAEGSLLTN 344 Query: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESAN 241 + + I+ + S D +L + + +D + + + Sbjct: 345 FESEKTGIIN-TLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEG----- 398 Query: 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKF 297 V F GL L+T D +++W G N + +F Sbjct: 399 ---ERSVLCSTFDKTGLRLITGEADKSIKIWKQDETATKESEPGLAWNPNLSAKRF 451 Score = 54.5 bits (129), Expect = 7e-08, Method: Composition-based stats. Identities = 16/95 (16%), Positives = 31/95 (32%) Query: 277 GENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKT 336 + + + + F+ +T+ V+ + +G+ T L GH T Sbjct: 125 WHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMT 184 Query: 337 VDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPD 371 V L+S S D + W + + D Sbjct: 185 VRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRD 219 >5XYI-g nrPDB Length = 335 Score = 167 bits (423), Expect = 6e-42, Method: Composition-based stats. Identities = 72/344 (20%), Positives = 138/344 (40%), Gaps = 53/344 (15%) Query: 36 RDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP 95 R H I +++I+ E Y++S D +++ L + Q + IG Sbjct: 26 RATFVGHNAAIESIEID-NEHNYLVSASRDKSALVWKLNRTQEQ--WATPFTRLIG---- 78 Query: 96 DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF-NFEETVYSHHMSPVST 154 H + V V D +SS+D TL++WD +T T +F ++ V SP + Sbjct: 79 --HNHFVSDVSLS-RDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNR 135 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYD----YILATASADSR 210 + + R +V++ ++ G LQ + +V+ +P D ++A D + Sbjct: 136 R---IISVGRDNQVKIWNI-LGENKAELQC-SSWVTSVACAPMADETSPLVIAVGCWDGK 190 Query: 211 VKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMR 270 V +W + + + + AH+G+ + FT DG ++T G+D ++ Sbjct: 191 VYIWSIEKEAKLIKEFK---------------AHDGRCTSVDFTPDGKWVITGGSDRKVV 235 Query: 271 LWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITML 330 +W + NG T + + + +C + Y IAV+ + + +QI ++ Sbjct: 236 MWLTENGAKT------ISFTAPSPVHAVAACPTQAWICAATY-EGIAVWDIGAKQQIDLV 288 Query: 331 K-----------GHYKTVDCCVFQSNFQELYSGSRDCNILAWVP 363 + G C + ++ LYSG D +I AW Sbjct: 289 QPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWEV 332 Score = 105 bits (260), Expect = 5e-23, Method: Composition-based stats. Identities = 39/225 (17%), Positives = 81/225 (36%), Gaps = 29/225 (12%) Query: 152 VSTKHCLVAVGTRGPKVQLCDLK-----SGSCSHILQGHRQEILAVSWSPRYDYILATAS 206 + +H + +R + L + L GH + VS S ++L + S Sbjct: 41 IDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLSRDASHLLTS-S 99 Query: 207 ADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTD 266 DS ++LWD+ ++ + H V G+ F+ +++VG D Sbjct: 100 WDSTLRLWDLS----------------TRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRD 143 Query: 267 NRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPY--GSTIAVYTVYSG 324 N++++WN GEN C++ + +S V + ++++ Sbjct: 144 NQVKIWNI-LGEN---KAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKE 199 Query: 325 -EQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEP 368 + I K H F + + + +G D ++ W+ Sbjct: 200 AKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAK 244 Score = 81.9 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 37/201 (18%), Positives = 67/201 (33%), Gaps = 24/201 (11%) Query: 177 SCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQA 236 + GH I ++ ++Y L +AS D +W + R T Sbjct: 24 APRATFVGHNAAIESIEIDNEHNY-LVSASRDKSALVWKLNRTQEQWATP---------- 72 Query: 237 VESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLK 296 + HN V+ + + D HLLT D+ +RLW+ S + G G+ Sbjct: 73 -FTRLIGHNHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLG--HKKDVLGVT 129 Query: 297 FTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQE-----LYS 351 F+ C+ + V + + ++ + GE L+ V E + Sbjct: 130 FS---PCNRRIISVGRDNQVKIWNIL-GENKAELQC-SSWVTSVACAPMADETSPLVIAV 184 Query: 352 GSRDCNILAWVPSLYEPVPDD 372 G D + W + + Sbjct: 185 GCWDGKVYIWSIEKEAKLIKE 205 Score = 73.4 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 19/144 (13%), Positives = 44/144 (30%) Query: 236 AVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGL 295 A + HN + + ++ +L++ D +W + + + Sbjct: 24 APRATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFV 83 Query: 296 KFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRD 355 +S + + ST+ ++ + + + GH K V F + + S RD Sbjct: 84 SDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRD 143 Query: 356 CNILAWVPSLYEPVPDDDETTTKS 379 + W + S Sbjct: 144 NQVKIWNILGENKAELQCSSWVTS 167 >4N14-A nrPDB Length = 314 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 61/284 (21%), Positives = 116/284 (40%), Gaps = 28/284 (9%) Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLV 159 Y + V W +G + + D ++ +W ++ + E+ + + Sbjct: 22 YYLNLVDWS---SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYL 78 Query: 160 AVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRA 219 AVGT +VQL D++ + H + ++SW+ YIL++ S + DVR A Sbjct: 79 AVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVA 135 Query: 220 SGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEN 279 + TL + H+ +V GL + DG HL + G DN + +W S+ GE Sbjct: 136 EHHVATL---------------SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEG 180 Query: 280 TLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGST---IAVYTVYSGEQITMLKGHYKT 336 V + + +K C S + G++ I ++ V SG ++ + H + Sbjct: 181 GWVPL-QTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ- 238 Query: 337 VDCCVFQSNFQELYS--GSRDCNILAWVPSLYEPVPDDDETTTK 378 V ++ +++EL S G ++ W V + T++ Sbjct: 239 VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSR 282 Score = 80.7 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 35/241 (14%), Positives = 87/241 (36%), Gaps = 53/241 (21%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPV--------------------- 54 L + + + ++ ++ K H + +L Sbjct: 78 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH 137 Query: 55 -------------------EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP 95 +GR++ SGG+D ++ ++ ++ + + + Sbjct: 138 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP--SAPGEGGW-------VPLQTF 188 Query: 96 DVHRYSVETVQWYPHDTGMFTS--SSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVS 153 H+ +V+ V W P + + + + D+ +++W+ + + V S SP Sbjct: 189 TQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSP-H 247 Query: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKL 213 K + G ++ + + + L+GH +L+++ SP +A+A+AD ++L Sbjct: 248 YKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGAT-VASAAADETLRL 306 Query: 214 W 214 W Sbjct: 307 W 307 Score = 64.2 bits (154), Expect = 9e-11, Method: Composition-based stats. Identities = 34/191 (17%), Positives = 61/191 (31%), Gaps = 27/191 (14%) Query: 192 VSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGL 251 V WS +LA A D+ V LW + + G ++ + Sbjct: 27 VDWS--SGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPG--------------EYISSV 69 Query: 252 CFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVP 311 + +G +L + ++LW+ + S +S + Sbjct: 70 AWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSAR--------VGSLSWNSYILSSG 121 Query: 312 YGST-IAVYTVYSGEQ-ITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPV 369 S I + V E + L GH + V + + + L SG D + W + E Sbjct: 122 SRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG 181 Query: 370 PDDDETTTKSQ 380 +T T+ Q Sbjct: 182 WVPLQTFTQHQ 192 Score = 51.5 bits (121), Expect = 6e-07, Method: Composition-based stats. Identities = 32/200 (16%), Positives = 58/200 (29%), Gaps = 48/200 (24%) Query: 3 GFLSARQTGLEDPLRLRRAESTRRVLGLELNKD--------------------------- 35 G + + + + ++ V GL D Sbjct: 125 GHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVP 184 Query: 36 RDVERIHGGGINTLDIEPVEGRYMLSGGS--DGVIVLYDLENSSRQSYYTCKAVCSIGRD 93 H G + + P + + +GG D I ++++ C C D Sbjct: 185 LQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV----------CSGACLSAVD 234 Query: 94 HPDVHRYSVETVQWYPHDTGMFTSSSF-DKTLKVWDTNTL-QTADVFNFEETVYSHHMSP 151 V ++ W PH + + F L +W T+ + A++ V S MSP Sbjct: 235 AHSQ----VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP 290 Query: 152 VSTKHCLVAVGTRGPKVQLC 171 VA ++L Sbjct: 291 ---DGATVASAAADETLRLW 307 >5GAN-H nrPDB Length = 465 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 63/291 (21%), Positives = 108/291 (37%), Gaps = 34/291 (11%) Query: 32 LNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIG 91 L H G I +D P M+S DG+I + N V Sbjct: 207 LQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLV---- 262 Query: 92 RDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSP 151 H + V+++P S+S D T ++WD +T Q + + Sbjct: 263 -----GHERRISDVKYHPSGK-FIGSASHDMTWRLWDASTHQELLLQEGHDK--GVFSLS 314 Query: 152 VSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRV 211 LV G L D++SGS L GH + I V+WSP Y +AT D + Sbjct: 315 FQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNG-YQVATGGGDGII 373 Query: 212 KLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD--GLHLLTVGTDNRM 269 +WD+R+ + + + AH V + F+ + G L++ G DN + Sbjct: 374 NVWDIRK--------------RDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLI 419 Query: 270 RLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYT 320 +++S + G + ++ K + +S S V + +I ++ Sbjct: 420 NVYSSDT----WLKMGSLAGHTDKIISLDIS-NNSHFLVSGGWDRSIKLWN 465 Score = 151 bits (382), Expect = 3e-37, Method: Composition-based stats. Identities = 59/346 (17%), Positives = 121/346 (34%), Gaps = 36/346 (10%) Query: 18 LRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSS 77 L R +R+ LEL + V I+ + + + + +G G DL+ + Sbjct: 153 LSRRTELQRMANLELAGSQLVS---TKPISAVSLS-TDDMVVATGSWAG-----DLQVLN 203 Query: 78 RQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADV 137 Q D H + + W+P S + D +K + + + Sbjct: 204 SQ-------TLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLR 256 Query: 138 FNFEETVYSHHMSPVS--TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 195 + + +S V + + +L D + + +GH + + ++S+ Sbjct: 257 LLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQ 316 Query: 196 PRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS 255 ++ + DS LWD+R S + H+ + + ++ Sbjct: 317 CDGS-LVCSGGMDSLSMLWDIRSGSKVMT----------------LAGHSKPIYTVAWSP 359 Query: 256 DGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGST 315 +G + T G D + +W+ + +N N ++F+ G + V Y + Sbjct: 360 NGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDG-GKKLVSCGYDNL 418 Query: 316 IAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 I VY+ + ++ L GH + +N L SG D +I W Sbjct: 419 INVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLW 464 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 39/208 (18%), Positives = 76/208 (36%), Gaps = 22/208 (10%) Query: 13 EDPLRLRRAES--TRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVL 70 + A T R+ +++ ++ H G+ +L + +G + SGG D + +L Sbjct: 275 PSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQ-CDGSLVCSGGMDSLSML 333 Query: 71 YDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDT- 129 +D+ + S+ H + TV W P+ + + D + VWD Sbjct: 334 WDIRSGSKVMTLAG-------------HSKPIYTVAWSPNGYQV-ATGGGDGIINVWDIR 379 Query: 130 --NTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQ 187 + Q + V S LV+ G + + + L GH Sbjct: 380 KRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCG-YDNLINVYSSDTWLKMGSLAGHTD 438 Query: 188 EILAVSWSPRYDYILATASADSRVKLWD 215 +I+++ S + L + D +KLW+ Sbjct: 439 KIISLDIS-NNSHFLVSGGWDRSIKLWN 465 Score = 103 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 44/279 (15%), Positives = 82/279 (29%), Gaps = 31/279 (11%) Query: 99 RYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCL 158 + V D + + S+ L+V ++ TLQ + + Sbjct: 175 TKPISAVSLS-TDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQ 233 Query: 159 VAVGTRGPKVQLCDLKSGS----CSHILQGHRQEILAVSWSPRYDYILATASADSRVKLW 214 + ++ + L GH + I V + P + +AS D +LW Sbjct: 234 MISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSG-KFIGSASHDMTWRLW 292 Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 D L+ H+ V L F DG + + G D+ LW+ Sbjct: 293 DASTHQELLLQE----------------GHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDI 336 Query: 275 SNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGE--QITMLKG 332 +G + G K + + I V+ + + Q+ + Sbjct: 337 RSGSKVMTLAGH-----SKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILA 391 Query: 333 HYKTVDCCVFQSN--FQELYSGSRDCNILAWVPSLYEPV 369 H V F ++L S D I + + + Sbjct: 392 HRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKM 430 Score = 78.8 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 38/206 (18%), Positives = 73/206 (35%), Gaps = 23/206 (11%) Query: 186 RQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHN 245 + I AVS S D ++AT S +++ + + LD H Sbjct: 175 TKPISAVSLSTD-DMVVATGSWAGDLQVLNSQTLQPLTQKLDS---------------HV 218 Query: 246 GKVNGLCFTSDGL-HLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCS 304 GK+ + + D +++ D ++ + SN E L G + + ++ + Sbjct: 219 GKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGH-ERRISDVKYHPSG 277 Query: 305 SEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPS 364 + T ++ + +++ + +GH K V FQ + + SG D + W Sbjct: 278 KFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIR 337 Query: 365 LYEPVPDDDETTTKSQLNPAFEDAWS 390 V T P + AWS Sbjct: 338 SGSKV-----MTLAGHSKPIYTVAWS 358 >3MKQ-A nrPDB Length = 814 Score = 163 bits (413), Expect = 9e-41, Method: Composition-based stats. Identities = 48/296 (16%), Positives = 100/296 (33%), Gaps = 33/296 (11%) Query: 96 DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTL-QTADVFNFEETVYSHHMSPVST 154 V+ + ++P + + ++ + +++W+ T + + E V + Sbjct: 10 SNRSDRVKGIDFHPTEPWVL-TTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIA--- 65 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLW 214 + + VG+ ++++ + +G + H I +++ P Y+L + S D VKLW Sbjct: 66 RKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVL-SGSDDLTVKLW 124 Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS-DGLHLLTVGTDNRMRLWN 273 + T + H V + F D + D +++W+ Sbjct: 125 NWENNWALEQTFE---------------GHEHFVMCVAFNPKDPSTFASGCLDRTVKVWS 169 Query: 274 SSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGH 333 G++T + TI ++ + + L+GH Sbjct: 170 L--GQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGH 227 Query: 334 YKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAW 389 V VF + SGS D + W S Y+ + LN E +W Sbjct: 228 MSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYK---------VEKTLNVGLERSW 274 Score = 140 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 49/253 (19%), Positives = 95/253 (37%), Gaps = 21/253 (8%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 + + + RV + H I ++ + P + Y+LSG D + L++ EN Sbjct: 70 IIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKP-YVLSGSDDLTVKLWNWEN 128 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 + + + + H + V V + P D F S D+T+KVW Sbjct: 129 N-----WALEQTF-------EGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPN 176 Query: 136 DVFNF--EETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVS 193 E V P+ K ++ + +++ D ++ SC L+GH + Sbjct: 177 FTLTTGQERGVNYVDYYPLPDKPYMI-TASDDLTIKIWDYQTKSCVATLEGHMSNVSFAV 235 Query: 194 WSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCF 253 + P I+ + S D +K+W+ TL+ + S + + T + Sbjct: 236 FHPTLP-IIISGSEDGTLKIWN-SSTYKVEKTLNVGLER-SWCIATHPTGRKNYIASG-- 290 Query: 254 TSDGLHLLTVGTD 266 +G +L++G D Sbjct: 291 FDNGFTVLSLGND 303 Score = 66.9 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 22/128 (17%), Positives = 43/128 (33%), Gaps = 5/128 (3%) Query: 237 VESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLK 296 ++ + + +V G+ F +LT R+ +WN V +V + K Sbjct: 5 IKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYET--QVEVRSIQVTETPVRAGK 62 Query: 297 FTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDC 356 F + + I V+ +GE++ + H + + SGS D Sbjct: 63 FI---ARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDL 119 Query: 357 NILAWVPS 364 + W Sbjct: 120 TVKLWNWE 127 Score = 60.3 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 39/342 (11%), Positives = 96/342 (28%), Gaps = 55/342 (16%) Query: 12 LEDP--LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIV 69 L D + + T ++ + H ++ P ++SG DG + Sbjct: 195 LPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLP-IIISGSEDGTLK 253 Query: 70 LYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDT 129 +++ S Y + ++G + + +P + +S FD V Sbjct: 254 IWN------SSTYKVEKTLNVGLERS-------WCIATHPTGRKNYIASGFDNGFTVLSL 300 Query: 130 NTLQ-TADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQE 188 + T + + V+S + ++ AV +V L +E Sbjct: 301 GNDEPTLSLDPVGKLVWSGGKNAAASD-IFTAVIRGNEEV--------EQDEPLSLQTKE 351 Query: 189 ILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKV 248 + +V P+ +G +T+ + GK Sbjct: 352 LGSVDVFPQSL----------------AHSPNGRFVTVVGDGEYVIYTALAWRNKAFGKC 395 Query: 249 NGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFV 308 + D + +++ + K + + + S + Sbjct: 396 QDFVWGPDSNSYALIDETGQIKYY----------KNFKEVTSWSVPMHSAIDRLFSGALL 445 Query: 309 FVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELY 350 V + + +G + + + K V ++ N + + Sbjct: 446 GVKSDGFVYFFDWDNGTLVRRIDVNAKDV---IWSDNGELVM 484 Score = 38.7 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 13/86 (15%), Positives = 28/86 (32%) Query: 286 KVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSN 345 K +N +K + Y + ++ + ++ ++ V F + Sbjct: 7 KTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIAR 66 Query: 346 FQELYSGSRDCNILAWVPSLYEPVPD 371 + GS D I + + E V D Sbjct: 67 KNWIIVGSDDFRIRVFNYNTGEKVVD 92 >5WLC-LO nrPDB Length = 923 Score = 162 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 59/366 (16%), Positives = 120/366 (32%), Gaps = 46/366 (12%) Query: 16 LRLRRAESTRRVLGL---ELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYD 72 + + + ++ + E N H + + + + DG + +++ Sbjct: 161 ILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMG-AFFSHDQEKIYTVSKDGAVFVWE 219 Query: 73 LENSSRQSYYTCKA---------VCSIGRDHPDVH-----RYSVETVQWYPHDTGMFTSS 118 + H + V+ V ++P + Sbjct: 220 FTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATR-LLAVG 278 Query: 119 SFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSC 178 +++D + + + +S T L ++ ++ + + +S S Sbjct: 279 FTSGEFRLYDLPDFTLIQQLSMGQN-PVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESY 337 Query: 179 SHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVE 238 QGH ++++SP ++ TAS D ++K+WD+ + CL T ++ Sbjct: 338 ILKQQGHFDSTNSLAYSPDGSRVV-TASEDGKIKVWDI-TSGFCLATFEE---------- 385 Query: 239 SANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFT 298 H V + F G + + D +R W+ N G + ++F Sbjct: 386 -----HTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTG------TERIQFN 434 Query: 299 V-SCGCSSEFVFVPYGST--IAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRD 355 + S E V I V++V +G+ + L GH V C F L S S D Sbjct: 435 CLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWD 494 Query: 356 CNILAW 361 I W Sbjct: 495 KTIRIW 500 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 56/322 (17%), Positives = 117/322 (36%), Gaps = 49/322 (15%) Query: 26 RVLGLELNKDRDV--ERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYT 83 ++L E + + ++ H N+L P +G +++ DG I ++D+ + Sbjct: 326 QLLVYEWQSESYILKQQGHFDSTNSLAYSP-DGSRVVTASEDGKIKVWDITSG------F 378 Query: 84 CKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEET 143 C A + H SV VQ+ MF SSS D T++ WD + F E Sbjct: 379 CLATF-------EEHTSSVTAVQFAKRGQVMF-SSSLDGTVRAWDLIRYRNFRTFTGTER 430 Query: 144 VYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILA 203 + + ++ + + A + + +++G L GH + +S+S +LA Sbjct: 431 IQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENS-VLA 489 Query: 204 TASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTV 263 +AS D +++W + S + ++ ++ V L DG + Sbjct: 490 SASWDKTIRIWSIFGRSQQVEPIEVYSD----------------VLALSMRPDGKEVAVS 533 Query: 264 GTDNRMRLWNSSNGENT------------LVNYGKVCNNSKKGLKF--TVSCGCSSE-FV 308 ++ ++N + + N + + + KF T+ V Sbjct: 534 TLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIV 593 Query: 309 FVPYGSTIAVYTVYSGEQITML 330 ++I +Y V + + Sbjct: 594 AGGNNNSICLYDVPNEVLLKRF 615 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 56/353 (15%), Positives = 111/353 (31%), Gaps = 61/353 (17%) Query: 25 RRVLGL-ELNKDRD--------VERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 ++ ++NKDR V H I +L + R++L+ D ++ +++ Sbjct: 119 LQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQ-DSRFILTTSKDLSAKIWSVDS 177 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 + T + HR V ++ HD + S D + VW+ + Sbjct: 178 EEKNLAATTF----------NGHRDYVMG-AFFSHDQEKIYTVSKDGAVFVWEFTKRPSD 226 Query: 136 DVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 195 D N E +S + + H ++ ++ V++ Sbjct: 227 DDDNESEDDDKQEEVDISKYSWRI-----------------TKKHFFYANQAKVKCVTFH 269 Query: 196 PRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS 255 P +LA +L+D+ + + VN + Sbjct: 270 PATR-LLAVGFTSGEFRLYDL----------------PDFTLIQQLSMGQNPVNTVSVNQ 312 Query: 256 DGLHLLTVGTD-NRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGS 314 G L + ++ ++ + L G +S L ++ S V Sbjct: 313 TGEWLAFGSSKLGQLLVYEWQSESYILKQQG--HFDSTNSLAYS---PDGSRVVTASEDG 367 Query: 315 TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYE 367 I V+ + SG + + H +V F Q ++S S D + AW Y Sbjct: 368 KIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYR 420 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 63/378 (16%), Positives = 124/378 (32%), Gaps = 47/378 (12%) Query: 26 RVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCK 85 V L NK E H I +D+ +G ++S DG +L + + + ++ K Sbjct: 38 SVFDLINNKSFTFEYEHRKNIAAIDLN-KQGTLLISIDEDGRAILVNFKARNVLHHFNFK 96 Query: 86 AVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVW---DTNTLQTADVFNFEE 142 CS V++ P D +F +S + L++W D N + F Sbjct: 97 EKCS--------------AVKFSP-DGRLFALASG-RFLQIWKTPDVNKDRQFAPF-VRH 139 Query: 143 TVYSHHMSPV-----STKHCLVAVGTRGPKVQLCDLKSGS---CSHILQGHRQEILAVSW 194 V++ H + S + ++ ++ + S + GHR ++ + Sbjct: 140 RVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFF 199 Query: 195 SPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAV-----------ESANTA 243 S + I T S D V +W+ + + + K + V + A Sbjct: 200 SHDQEKIY-TVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYA 258 Query: 244 HNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGC 303 + KV + F L T RL++ + + + + Sbjct: 259 NQAKVKCVTFHPATRLLAVGFTSGEFRLYDL-----PDFTLIQQLSMGQNPVNTVSVNQT 313 Query: 304 SSEFVFVPYG-STIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWV 362 F + VY S I +GH+ + + + + + + S D I W Sbjct: 314 GEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWD 373 Query: 363 PSLYEPVPDDDETTTKSQ 380 + + +E T+ Sbjct: 374 ITSGFCLATFEEHTSSVT 391 Score = 29.5 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 9/60 (15%), Positives = 21/60 (35%) Query: 298 TVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCN 357 ++ + + P G+ ++V+ + + + T H K + L S D Sbjct: 19 NITFSDDGKQLLSPVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGR 78 >4XYI-A nrPDB Length = 430 Score = 161 bits (406), Expect = 6e-40, Method: Composition-based stats. Identities = 58/243 (23%), Positives = 101/243 (41%), Gaps = 13/243 (5%) Query: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 R H L ++ + +G D I ++D++ S K++ H Sbjct: 179 RHHTSEGFGLGWNFIQEGTLATGTEDTSICVWDIKGKSLSLE---KSIDVAPVSVYHRHT 235 Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTN----TLQTADVFNFEETVYSHHMSPVSTK 155 V +Q++ + TS S D TL++ DT + + V E+ V +P + Sbjct: 236 AVVNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFND- 294 Query: 156 HCLVAVGTRGPKVQLCDLKS-GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLW 214 L+A + V L DL+ H L+GH E+ V WSP + IL T+S D RV +W Sbjct: 295 -YLLATASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVW 353 Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLH-LLTVGTDNRMRLWN 273 D+ + D +G + H +V+ L + + L ++ DN +++W+ Sbjct: 354 DLSKIGEEQTVEDSEDGAPELMF--MHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWS 411 Query: 274 SSN 276 S Sbjct: 412 PSK 414 Score = 124 bits (310), Expect = 7e-29, Method: Composition-based stats. Identities = 72/337 (21%), Positives = 121/337 (35%), Gaps = 67/337 (19%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H G +N P + + G +G ++DL Q + H Sbjct: 130 HEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRH-----HTSE 184 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ---TADVFNFEETVYSHHMSPVST---- 154 + W G + + D ++ VWD + +VY H + V+ Sbjct: 185 GFGLGWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFH 244 Query: 155 --KHCLVAVGTRGPKVQLCDLK---SGSCSHILQGHRQEILAVSWSPRYDYILATASADS 209 L+ + +Q+ D + S S S ++ H Q + V+++P DY+LATASAD Sbjct: 245 LQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADH 304 Query: 210 RVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS-DGLHLLTVGTDNR 268 V LWD+RR + L TL+ H +V + ++ D L+T TD R Sbjct: 305 TVALWDLRRLNQRLHTLE---------------GHEDEVYNVQWSPHDEPILVTSSTDRR 349 Query: 269 MRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQIT 328 + +W+ S + + +S+ G + E + Sbjct: 350 VCVWDLSK-----IGEEQTVEDSEDG----------------------------APELMF 376 Query: 329 MLKGHYKTVDCCVFQSNFQE-LYSGSRDCNILAWVPS 364 M GH V + N + L S + D + W PS Sbjct: 377 MHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPS 413 Score = 99 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 45/244 (18%), Positives = 86/244 (35%), Gaps = 38/244 (15%) Query: 13 EDPLRLRRAESTRRVLGLE-----LNKDRDVERI-----HGGGINTLDIEPVEGRYMLSG 62 E L +++ V ++ L K DV + H +N L + S Sbjct: 195 EGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTSV 254 Query: 63 GSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDK 122 D + ++D S S C H V V + P + + ++S D Sbjct: 255 SDDCTLQIHDTRLPSSSSASQCVK----------AHEQPVNGVAFNPFNDYLLATASADH 304 Query: 123 TLKVWDTNTL-QTADVF-NFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSH 180 T+ +WD L Q E+ VY+ SP ++ + +V + DL Sbjct: 305 TVALWDLRRLNQRLHTLEGHEDEVYNVQWSP--HDEPILVTSSTDRRVCVWDLSKIGEEQ 362 Query: 181 ILQ--------------GHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITL 226 ++ GH + +SW+P ++LA+ + D+ +++W + +L Sbjct: 363 TVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSKVIWASDSL 422 Query: 227 DQHN 230 + Sbjct: 423 KIDS 426 >5FVM-C nrPDB Length = 303 Score = 160 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 60/270 (22%), Positives = 96/270 (35%), Gaps = 41/270 (15%) Query: 26 RVLGLELNKDRDV--ERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYT 83 R+ + N V H G + ++ + E R+M+S DG I ++D+ + S Q Y Sbjct: 56 RLYDIRSNNPNPVSSFEGHKGNVTSIAFQQ-ENRWMVSSSEDGTIKVWDVRSPSVQRNYK 114 Query: 84 CKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEET 143 H V V +P+ S D +++WD Q + E+ Sbjct: 115 --------------HNAPVNEVAIHPNQGE-LISCDQDGNIRIWDLGENQCTNQLTPEDN 159 Query: 144 VYSHHMSPVSTKHCLVAVGTRGPKVQLC------DLKSGSCSHILQGHRQEILAVSWSPR 197 +S S LVA G + D + + H + I V S Sbjct: 160 TPLQSLSVASDGSMLVA-GNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSAD 218 Query: 198 YDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDG 257 LAT SAD ++W++ TLD H V F++D Sbjct: 219 VKN-LATCSADHTARVWNIEDNYQLETTLD---------------GHQRWVWDCAFSADS 262 Query: 258 LHLLTVGTDNRMRLWNSSNGENTLVNYGKV 287 +L+T +D+ +RLW+ S E G Sbjct: 263 AYLVTACSDHYVRLWDLSTSEIVRQYGGHH 292 Score = 123 bits (308), Expect = 1e-28, Method: Composition-based stats. Identities = 54/284 (19%), Positives = 104/284 (36%), Gaps = 41/284 (14%) Query: 114 MFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDL 173 + S+ +D T++ W+ T + ++ + + S K L A G V+L D+ Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADS-QVNRLEITSDKKYLAAAGHL--HVRLYDI 60 Query: 174 KSGSC--SHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNG 231 +S + +GH+ + ++++ +++++ S D +K+WDVR S Sbjct: 61 RSNNPNPVSSFEGHKGNVTSIAFQQENRWMVSS-SEDGTIKVWDVRSPSVQR-------- 111 Query: 232 KKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNS 291 N HN VN + + L++ D +R+W+ GEN N +N Sbjct: 112 ---------NYKHNAPVNEVAIHPNQGELISCDQDGNIRIWDL--GENQCTNQLTPEDN- 159 Query: 292 KKGLKFTVSCGCSSEFVFVPYGSTIAVY------TVYSGEQITMLKGHYKTVDCCVFQSN 345 L+ S V V+ + E +T K H K + + ++ Sbjct: 160 -TPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSAD 218 Query: 346 FQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAW 389 + L + S D W D ++ L+ W Sbjct: 219 VKNLATCSADHTARVWNIE--------DNYQLETTLDGHQRWVW 254 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 48/329 (14%), Positives = 112/329 (34%), Gaps = 33/329 (10%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 L + T R + +N L+I + +Y+ + G + LYD+ + Sbjct: 5 LASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEIT-SDKKYLAAAGHLH-VRLYDIRS 62 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 ++ + + H+ +V ++ + + M SSS D T+KVWD + Sbjct: 63 NNPNPVSSF-----------EGHKGNVTSIAFQQENRWM-VSSSEDGTIKVWDVRSPSVQ 110 Query: 136 DVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQ-GHRQEILAVSW 194 + V + P + + + +++ DL C++ L + ++S Sbjct: 111 RNYKHNAPVNEVAIHPNQGE---LISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSV 167 Query: 195 SPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFT 254 + +L + +W + H + + +H + + + Sbjct: 168 ASDGS-MLVAGNNKGNCYVWRM----------PHHTDASTLEPVTKFKSHTKYITRVLLS 216 Query: 255 SDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGS 314 +D +L T D+ R+WN + + ++ + S+ V Sbjct: 217 ADVKNLATCSADHTARVWNIEDNYQL----ETTLDGHQRWVWDCAFSADSAYLVTACSDH 272 Query: 315 TIAVYTVYSGEQITMLKGHYKTVDCCVFQ 343 + ++ + + E + GH+K C Sbjct: 273 YVRLWDLSTSEIVRQYGGHHKGAVCVALN 301 Score = 91.9 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 32/239 (13%), Positives = 74/239 (30%), Gaps = 23/239 (9%) Query: 156 HCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 ++A ++ + +G CS +Q ++ + + Y+ A V+L+D Sbjct: 2 SVILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHL--HVRLYD 59 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 +R + S+ H G V + F + +++ D +++W+ Sbjct: 60 IRSNN--------------PNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVR 105 Query: 276 NGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYK 335 + + NY ++ + E + I ++ + + L Sbjct: 106 SP-SVQRNYKHNAPVNEVAIH-----PNQGELISCDQDGNIRIWDLGENQCTNQLTPEDN 159 Query: 336 TV-DCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSD 393 T S+ L +G+ N W + + T S+D Sbjct: 160 TPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSAD 218 Score = 44.5 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 18/83 (21%), Positives = 30/83 (36%), Gaps = 2/83 (2%) Query: 16 LRLRRAESTRRVLGLELNKDRDVE-RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLE 74 L A+ T RV +E N + H + + Y+++ SD + L+DL Sbjct: 222 LATCSADHTARVWNIEDNYQLETTLDGHQRWVWDCAFS-ADSAYLVTACSDHYVRLWDLS 280 Query: 75 NSSRQSYYTCKAVCSIGRDHPDV 97 S Y ++ DV Sbjct: 281 TSEIVRQYGGHHKGAVCVALNDV 303 >2YNP-A nrPDB Length = 604 Score = 159 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 48/296 (16%), Positives = 100/296 (33%), Gaps = 33/296 (11%) Query: 96 DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTL-QTADVFNFEETVYSHHMSPVST 154 V+ + ++P + + ++ + +++W+ T + + E V + Sbjct: 10 SNRSDRVKGIDFHPTEPWVL-TTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIA--- 65 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLW 214 + + VG+ ++++ + +G + H I +++ P Y+L + S D VKLW Sbjct: 66 RKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVL-SGSDDLTVKLW 124 Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS-DGLHLLTVGTDNRMRLWN 273 + T + H V + F D + D +++W+ Sbjct: 125 NWENNWALEQTFE---------------GHEHFVMCVAFNPKDPSTFASGCLDRTVKVWS 169 Query: 274 SSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGH 333 G++T + TI ++ + + L+GH Sbjct: 170 L--GQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGH 227 Query: 334 YKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAW 389 V VF + SGS D + W S Y+ + LN E +W Sbjct: 228 MSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYK---------VEKTLNVGLERSW 274 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 49/253 (19%), Positives = 95/253 (37%), Gaps = 21/253 (8%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 + + + RV + H I ++ + P + Y+LSG D + L++ EN Sbjct: 70 IIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKP-YVLSGSDDLTVKLWNWEN 128 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 + + + + H + V V + P D F S D+T+KVW Sbjct: 129 N-----WALEQTF-------EGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPN 176 Query: 136 DVFNF--EETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVS 193 E V P+ K ++ + +++ D ++ SC L+GH + Sbjct: 177 FTLTTGQERGVNYVDYYPLPDKPYMI-TASDDLTIKIWDYQTKSCVATLEGHMSNVSFAV 235 Query: 194 WSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCF 253 + P I+ + S D +K+W+ TL+ + S + + T + Sbjct: 236 FHPTLP-IIISGSEDGTLKIWN-SSTYKVEKTLNVGLER-SWCIATHPTGRKNYIASG-- 290 Query: 254 TSDGLHLLTVGTD 266 +G +L++G D Sbjct: 291 FDNGFTVLSLGND 303 Score = 65.7 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 23/128 (17%), Positives = 43/128 (33%), Gaps = 5/128 (3%) Query: 237 VESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLK 296 ++ + + +V G+ F +LT R+ LWN V +V + K Sbjct: 5 IKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYET--QVEVRSIQVTETPVRAGK 62 Query: 297 FTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDC 356 F + + I V+ +GE++ + H + + SGS D Sbjct: 63 FI---ARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDL 119 Query: 357 NILAWVPS 364 + W Sbjct: 120 TVKLWNWE 127 Score = 58.4 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 38/342 (11%), Positives = 95/342 (27%), Gaps = 55/342 (16%) Query: 12 LEDP--LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIV 69 L D + + T ++ + H ++ P ++SG DG + Sbjct: 195 LPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLP-IIISGSEDGTLK 253 Query: 70 LYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDT 129 +++ Y + ++G + + +P + +S FD V Sbjct: 254 IWNSST------YKVEKTLNVGLERS-------WCIATHPTGRKNYIASGFDNGFTVLSL 300 Query: 130 NTLQ-TADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQE 188 + T + + V+S + ++ AV +V L +E Sbjct: 301 GNDEPTLSLDPVGKLVWSGGKNAAASD-IFTAVIRGNEEV--------EQDEPLSLQTKE 351 Query: 189 ILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKV 248 + +V P+ +G +T+ + GK Sbjct: 352 LGSVDVFPQSL----------------AHSPNGRFVTVVGDGEYVIYTALAWRNKAFGKC 395 Query: 249 NGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFV 308 + D + +++ + K + + + S + Sbjct: 396 QDFVWGPDSNSYALIDETGQIKYY----------KNFKEVTSWSVPMHSAIDRLFSGALL 445 Query: 309 FVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELY 350 V + + +G + + + K V ++ N + + Sbjct: 446 GVKSDGFVYFFDWDNGTLVRRIDVNAKDV---IWSDNGELVM 484 Score = 37.6 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 13/86 (15%), Positives = 28/86 (32%) Query: 286 KVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSN 345 K +N +K + Y + ++ + ++ ++ V F + Sbjct: 7 KTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIAR 66 Query: 346 FQELYSGSRDCNILAWVPSLYEPVPD 371 + GS D I + + E V D Sbjct: 67 KNWIIVGSDDFRIRVFNYNTGEKVVD 92 >5I2T-A nrPDB Length = 742 Score = 159 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 59/366 (16%), Positives = 120/366 (32%), Gaps = 46/366 (12%) Query: 16 LRLRRAESTRRVLGL---ELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYD 72 + + + ++ + E N H + + + + DG + +++ Sbjct: 186 ILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMG-AFFSHDQEKIYTVSKDGAVFVWE 244 Query: 73 LENSSRQSYYTCKA---------VCSIGRDHPDVH-----RYSVETVQWYPHDTGMFTSS 118 + H + V+ V ++P + Sbjct: 245 FTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATR-LLAVG 303 Query: 119 SFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSC 178 +++D + + + +S T L ++ ++ + + +S S Sbjct: 304 FTSGEFRLYDLPDFTLIQQLSMGQN-PVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESY 362 Query: 179 SHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVE 238 QGH ++++SP ++ TAS D ++K+WD+ + CL T ++ Sbjct: 363 ILKQQGHFDSTNSLAYSPDGSRVV-TASEDGKIKVWDI-TSGFCLATFEE---------- 410 Query: 239 SANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFT 298 H V + F G + + D +R W+ N G + ++F Sbjct: 411 -----HTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTG------TERIQFN 459 Query: 299 V-SCGCSSEFVFVPYGST--IAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRD 355 + S E V I V++V +G+ + L GH V C F L S S D Sbjct: 460 CLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWD 519 Query: 356 CNILAW 361 I W Sbjct: 520 KTIRIW 525 Score = 137 bits (345), Expect = 7e-33, Method: Composition-based stats. Identities = 56/322 (17%), Positives = 117/322 (36%), Gaps = 49/322 (15%) Query: 26 RVLGLELNKDRDV--ERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYT 83 ++L E + + ++ H N+L P +G +++ DG I ++D+ + Sbjct: 351 QLLVYEWQSESYILKQQGHFDSTNSLAYSP-DGSRVVTASEDGKIKVWDITSG------F 403 Query: 84 CKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEET 143 C A + H SV VQ+ MF SSS D T++ WD + F E Sbjct: 404 CLATF-------EEHTSSVTAVQFAKRGQVMF-SSSLDGTVRAWDLIRYRNFRTFTGTER 455 Query: 144 VYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILA 203 + + ++ + + A + + +++G L GH + +S+S +LA Sbjct: 456 IQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENS-VLA 514 Query: 204 TASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTV 263 +AS D +++W + S + ++ ++ V L DG + Sbjct: 515 SASWDKTIRIWSIFGRSQQVEPIEVYSD----------------VLALSMRPDGKEVAVS 558 Query: 264 GTDNRMRLWNSSNGENT------------LVNYGKVCNNSKKGLKF--TVSCGCSSE-FV 308 ++ ++N + + N + + + KF T+ V Sbjct: 559 TLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIV 618 Query: 309 FVPYGSTIAVYTVYSGEQITML 330 ++I +Y V + + Sbjct: 619 AGGNNNSICLYDVPNEVLLKRF 640 Score = 118 bits (295), Expect = 5e-27, Method: Composition-based stats. Identities = 56/353 (15%), Positives = 111/353 (31%), Gaps = 61/353 (17%) Query: 25 RRVLGL-ELNKDRD--------VERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 ++ ++NKDR V H I +L + R++L+ D ++ +++ Sbjct: 144 LQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQ-DSRFILTTSKDLSAKIWSVDS 202 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 + T + HR V ++ HD + S D + VW+ + Sbjct: 203 EEKNLAATTF----------NGHRDYVMG-AFFSHDQEKIYTVSKDGAVFVWEFTKRPSD 251 Query: 136 DVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 195 D N E +S + + H ++ ++ V++ Sbjct: 252 DDDNESEDDDKQEEVDISKYSWRI-----------------TKKHFFYANQAKVKCVTFH 294 Query: 196 PRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS 255 P +LA +L+D+ + + VN + Sbjct: 295 PATR-LLAVGFTSGEFRLYDL----------------PDFTLIQQLSMGQNPVNTVSVNQ 337 Query: 256 DGLHLLTVGTD-NRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGS 314 G L + ++ ++ + L G +S L ++ S V Sbjct: 338 TGEWLAFGSSKLGQLLVYEWQSESYILKQQG--HFDSTNSLAYS---PDGSRVVTASEDG 392 Query: 315 TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYE 367 I V+ + SG + + H +V F Q ++S S D + AW Y Sbjct: 393 KIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYR 445 Score = 114 bits (285), Expect = 6e-26, Method: Composition-based stats. Identities = 63/378 (16%), Positives = 124/378 (32%), Gaps = 47/378 (12%) Query: 26 RVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCK 85 V L NK E H I +D+ +G ++S DG +L + + + ++ K Sbjct: 63 SVFDLINNKSFTFEYEHRKNIAAIDLN-KQGTLLISIDEDGRAILVNFKARNVLHHFNFK 121 Query: 86 AVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVW---DTNTLQTADVFNFEE 142 CS V++ P D +F +S + L++W D N + F Sbjct: 122 EKCS--------------AVKFSP-DGRLFALASG-RFLQIWKTPDVNKDRQFAPF-VRH 164 Query: 143 TVYSHHMSPV-----STKHCLVAVGTRGPKVQLCDLKSGS---CSHILQGHRQEILAVSW 194 V++ H + S + ++ ++ + S + GHR ++ + Sbjct: 165 RVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFF 224 Query: 195 SPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAV-----------ESANTA 243 S + I T S D V +W+ + + + K + V + A Sbjct: 225 SHDQEKIY-TVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYA 283 Query: 244 HNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGC 303 + KV + F L T RL++ + + + + Sbjct: 284 NQAKVKCVTFHPATRLLAVGFTSGEFRLYDL-----PDFTLIQQLSMGQNPVNTVSVNQT 338 Query: 304 SSEFVFVPYG-STIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWV 362 F + VY S I +GH+ + + + + + + S D I W Sbjct: 339 GEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWD 398 Query: 363 PSLYEPVPDDDETTTKSQ 380 + + +E T+ Sbjct: 399 ITSGFCLATFEEHTSSVT 416 Score = 29.5 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 9/60 (15%), Positives = 21/60 (35%) Query: 298 TVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCN 357 ++ + + P G+ ++V+ + + + T H K + L S D Sbjct: 44 NITFSDDGKQLLSPVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGR 103 >3JB9-g nrPDB Length = 558 Score = 157 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 65/326 (19%), Positives = 109/326 (33%), Gaps = 35/326 (10%) Query: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 + H GI+ L P+ G +LSG D I ++++ + R T + H Sbjct: 263 KGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHD-RSLLRTFQG-----------HA 310 Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLV 159 + + + D F S+SFDKT+K+WDT + + FN + K Sbjct: 311 RPIRDLSFS-QDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEF 369 Query: 160 AVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRA 219 GT ++ D++S H I ++++ T S DS ++ W+ Sbjct: 370 LAGTADKRILQFDIRSPDIVQAYDHHLGGINSITFL-ENGKRFVTTSDDSSMRFWEYGT- 427 Query: 220 SGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEN 279 + H+ + +G + DN + ++ S E Sbjct: 428 ------------PVPIKFVADIAMHSMP--RVALRPNGKSIACQSLDNCIYVY--SAYEK 471 Query: 280 TLVNYGKVCN-NSKKGLKFTVSCGCSSEFVFVPYGSTIA-VYTVYSGEQITMLKGHYKTV 337 N KV S G V FVF S A + + + + L H V Sbjct: 472 YRQNKKKVFKGYSCSGYSLEVGFSPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPV 531 Query: 338 DCCVFQSNFQELYSGSR--DCNILAW 361 F + S D +I W Sbjct: 532 QSMAFHPQETSKVATSSIVDGSIKYW 557 Score = 145 bits (365), Expect = 3e-35, Method: Composition-based stats. Identities = 38/195 (19%), Positives = 72/195 (36%), Gaps = 20/195 (10%) Query: 176 GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQ 235 +GH + I + + P ++L + S D+++K+W+V L T Sbjct: 256 KKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQ-------- 307 Query: 236 AVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGL 295 H + L F+ DG L+ D ++LW++ G+ + + Sbjct: 308 -------GHARPIRDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNS---DRLTNCV 357 Query: 296 KFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRD 355 KF V +EF+ I + + S + + H ++ F N + + S D Sbjct: 358 KFQVDPDKPNEFLAGTADKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDD 417 Query: 356 CNILAWVPSLYEPVP 370 ++ W PVP Sbjct: 418 SSMRFW--EYGTPVP 430 >6QX9-4B nrPDB Length = 522 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 56/303 (18%), Positives = 103/303 (33%), Gaps = 46/303 (15%) Query: 25 RRVLGLELNKDRDVERIHGGGINTLDIEPVE-------GRYMLSGGSDGVIVLYDLENSS 77 ++ + R H + + P + S +DG + L+ L++ Sbjct: 255 CKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDE 314 Query: 78 RQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADV 137 + H V V W+P ++ +D++ ++WD + ++ Sbjct: 315 -------------PVADIEGHTVRVARVMWHPSGR-FLGTTCYDRSWRLWDLEAQE--EI 358 Query: 138 FNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPR 197 + E + L G ++ DL++G C L+GH +EI +++SP Sbjct: 359 LHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPN 418 Query: 198 YDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS-D 256 Y +AT S D+ K+WD+R+ C+ T+ AH V G+ F Sbjct: 419 G-YHIATGSGDNTCKVWDLRQ-RRCVYTIP---------------AHQNLVTGVKFEPIH 461 Query: 257 GLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTI 316 G LLT DN ++W G + Y T Sbjct: 462 GNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDI-----SSDGQLIATCSYDRTF 516 Query: 317 AVY 319 ++ Sbjct: 517 KLW 519 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 52/320 (16%), Positives = 107/320 (33%), Gaps = 30/320 (9%) Query: 45 GINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVET 104 I+ P + + + G+ L+ + + + + T Sbjct: 233 PISYCHFSP-NSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVF-----HPKST 286 Query: 105 VQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTR 164 V P D S + D ++K+W ++ + + M + Sbjct: 287 VSLDPKDVN-LASCAADGSVKLWSLDSDEPVADIEGHTVRVARVM--WHPSGRFLGTTCY 343 Query: 165 GPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLI 224 +L DL++ +GH + +++ + T D+ ++WD+R C++ Sbjct: 344 DRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGS-LAGTGGLDAFGRVWDLRTGR-CIM 401 Query: 225 TLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNY 284 L+ H ++ G+ F+ +G H+ T DN ++W+ V Sbjct: 402 FLE---------------GHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRC--VYT 444 Query: 285 GKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQS 344 N G+KF G + + Y +T ++T + L GH V S Sbjct: 445 IPAHQNLVTGVKFEPIHG--NFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISS 502 Query: 345 NFQELYSGSRDCNILAWVPS 364 + Q + + S D W+ Sbjct: 503 DGQLIATCSYDRTFKLWMAE 522 Score = 145 bits (365), Expect = 4e-35, Method: Composition-based stats. Identities = 47/276 (17%), Positives = 83/276 (30%), Gaps = 30/276 (10%) Query: 101 SVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSH------HMSPVST 154 + + P ++ M ++ + K+W T + Sbjct: 233 PISYCHFSP-NSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDP 291 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLW 214 K +A V+L L S ++GH + V W P L T D +LW Sbjct: 292 KDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGR-FLGTTCYDRSWRLW 350 Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 D+ L H+ V + F DG T G D R+W+ Sbjct: 351 DLEAQEEILHQE----------------GHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDL 394 Query: 275 SNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHY 334 G + G + G+ F+ + +T V+ + + + H Sbjct: 395 RTGRCIMFLEGHL--KEIYGINFSPN---GYHIATGSGDNTCKVWDLRQRRCVYTIPAHQ 449 Query: 335 KTVDCCVFQS-NFQELYSGSRDCNILAWVPSLYEPV 369 V F+ + L +G+ D W + P+ Sbjct: 450 NLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPL 485 Score = 141 bits (354), Expect = 6e-34, Method: Composition-based stats. Identities = 52/254 (20%), Positives = 93/254 (36%), Gaps = 35/254 (13%) Query: 20 RAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQ 79 A+ + ++ L+ ++ H + + P GR++ + D L+DLE Sbjct: 300 AADGSVKLWSLDSDEPVADIEGHTVRVARVMWHP-SGRFLGTTCYDRSWRLWDLEAQEEI 358 Query: 80 SYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN 139 H + H V + ++ D + + D +VWD T + Sbjct: 359 L-------------HQEGHSMGVYDIAFH-QDGSLAGTGGLDAFGRVWDLRTGRCIMFLE 404 Query: 140 FE-ETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRY 198 + +Y + SP +A G+ ++ DL+ C + + H+ + V + P + Sbjct: 405 GHLKEIYGINFSPN---GYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIH 461 Query: 199 DYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGL 258 L T + D+ K+W L TL H GKV GL +SDG Sbjct: 462 GNFLLTGAYDNTAKIW-THPGWSPLKTL---------------AGHEGKVMGLDISSDGQ 505 Query: 259 HLLTVGTDNRMRLW 272 + T D +LW Sbjct: 506 LIATCSYDRTFKLW 519 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 49/241 (20%), Positives = 78/241 (32%), Gaps = 31/241 (12%) Query: 136 DVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 195 + + H SP S ++A +L + + H L+GH + A+ + Sbjct: 226 SQIGDDRPISYCHFSPNSK---MLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFH 282 Query: 196 PRY-------DYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKV 248 P+ D LA+ +AD VKLW + + H +V Sbjct: 283 PKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPV----------------ADIEGHTVRV 326 Query: 249 NGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFV 308 + + G L T D RLW+ E L G G+ S Sbjct: 327 ARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSM-----GVYDIAFHQDGSLAG 381 Query: 309 FVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEP 368 + V+ + +G I L+GH K + F N + +GS D W Sbjct: 382 TGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRC 441 Query: 369 V 369 V Sbjct: 442 V 442 Score = 109 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 36/200 (18%), Positives = 67/200 (33%), Gaps = 19/200 (9%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 L + + R+ LE ++ + H G+ + +G +GG D ++DL Sbjct: 338 LGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQ-DGSLAGTGGLDAFGRVWDLRT 396 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 + + H + + + P+ + S D T KVWD + Sbjct: 397 GRCIMFL-------------EGHLKEIYGINFSPNGY-HIATGSGDNTCKVWDLRQRRCV 442 Query: 136 DVFN-FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSW 194 + V P+ + G ++ S L GH +++ + Sbjct: 443 YTIPAHQNLVTGVKFEPI--HGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDI 500 Query: 195 SPRYDYILATASADSRVKLW 214 S ++AT S D KLW Sbjct: 501 SSDGQ-LIATCSYDRTFKLW 519 Score = 87.7 bits (215), Expect = 7e-18, Method: Composition-based stats. Identities = 29/158 (18%), Positives = 53/158 (33%), Gaps = 18/158 (11%) Query: 18 LRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSS 77 ++ RV L + H I ++ P G ++ +G D ++DL Sbjct: 382 TGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSP-NGYHIATGSGDNTCKVWDLR--Q 438 Query: 78 RQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADV 137 R+ YT A H+ V V++ P + ++D T K+W Sbjct: 439 RRCVYTIPA-----------HQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKT 487 Query: 138 F-NFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLK 174 E V +S+ L+A + +L + Sbjct: 488 LAGHEGKVMGL---DISSDGQLIATCSYDRTFKLWMAE 522 Score = 76.1 bits (185), Expect = 2e-14, Method: Composition-based stats. Identities = 19/164 (11%), Positives = 55/164 (33%), Gaps = 7/164 (4%) Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 ++ + + H +S + + ++ F+ + L T +LW+ Sbjct: 201 EIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSV 260 Query: 275 SNGENTLVNYGKVCNNSKKGLKFTVSC-----GCSSEFVFVPYGSTIAVYTVYSGEQITM 329 + L++ + N + + F ++ ++++ S E + Sbjct: 261 P--DCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVAD 318 Query: 330 LKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDD 373 ++GH V ++ + + L + D + W E + + Sbjct: 319 IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQE 362 Score = 51.8 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 19/111 (17%), Positives = 36/111 (32%), Gaps = 10/111 (9%) Query: 278 ENTLVNYGKVCNNS--KKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYK 335 +L + C+ + + + S + +++V + L+GH Sbjct: 215 HKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNT 274 Query: 336 TVDCCVFQSNFQE--------LYSGSRDCNILAWVPSLYEPVPDDDETTTK 378 V VF L S + D ++ W EPV D + T + Sbjct: 275 NVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVR 325 >6N9G-C nrPDB Length = 353 Score = 155 bits (392), Expect = 2e-38, Method: Composition-based stats. Identities = 54/334 (16%), Positives = 107/334 (32%), Gaps = 39/334 (11%) Query: 34 KDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRD 93 K R + HG + +D + R ++S DG ++++D ++++ T Sbjct: 54 KTRRTLKGHGNKVLCMDWC-KDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCT------ 106 Query: 94 HPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSH--HMSP 151 V + P D V+ + ++ +++V H ++S Sbjct: 107 -------WVMACAYAPSGCA-IACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSA 158 Query: 152 VS--TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRY-DYILATASAD 208 S + + L D++SG GH ++L + +P + D Sbjct: 159 CSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCD 218 Query: 209 SRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNR 268 + +WD+R H VN + + G + D Sbjct: 219 KKAMVWDMRSGQCVQAFET----------------HESDVNSVRYYPSGDAFASGSDDAT 262 Query: 269 MRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQIT 328 RL++ + + + F++S TI V+ V G +++ Sbjct: 263 CRLYDLRADREVAIYSKESIIFGASSVDFSLS---GRLLFAGYNDYTINVWDVLKGSRVS 319 Query: 329 MLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWV 362 +L GH V + SGS D + W Sbjct: 320 ILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 353 Score = 126 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 41/200 (20%), Positives = 77/200 (38%), Gaps = 16/200 (8%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVE-GRYMLSGGSDGVIVLYDLE 74 + + T + +E + HG + LD+ P E G +SGG D +++D+ Sbjct: 168 ILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMR 227 Query: 75 NSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQT 134 + + H V +V++YP F S S D T +++D + Sbjct: 228 SGQ-------------CVQAFETHESDVNSVRYYPSGDA-FASGSDDATCRLYDLRADRE 273 Query: 135 ADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSW 194 +++ E ++ S L+ G + + D+ GS IL GH + + Sbjct: 274 VAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRV 333 Query: 195 SPRYDYILATASADSRVKLW 214 SP + S D +++W Sbjct: 334 SPDG-TAFCSGSWDHTLRVW 352 Score = 100 bits (249), Expect = 9e-22, Method: Composition-based stats. Identities = 47/288 (16%), Positives = 81/288 (28%), Gaps = 35/288 (12%) Query: 92 RDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSP 151 R H V + W D SSS D + VWD+ T Sbjct: 56 RRTLKGHGNKVLCMDWC-KDKRRIVSSSQDGKVIVWDSFTTNKEHAVTM--PCTWVMACA 112 Query: 152 VSTKHCLVAVGTRGPKVQLC------DLKSGSCSHILQGHRQEILAVSWSPRYDYILATA 205 + C +A G K + + + + H + A S+ D + TA Sbjct: 113 YAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSF-TNSDMQILTA 171 Query: 206 SADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD--GLHLLTV 263 S D LWDV + H V L G ++ Sbjct: 172 SGDGTCALWDVESGQLLQ----------------SFHGHGADVLCLDLAPSETGNTFVSG 215 Query: 264 GTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYS 323 G D + +W+ +G+ + + + F +T +Y + + Sbjct: 216 GCDKKAMVWDMRSGQCV-----QAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRA 270 Query: 324 GEQITMLKGHYK--TVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPV 369 ++ + F + + L++G D I W V Sbjct: 271 DREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRV 318 Score = 31.0 bits (68), Expect = 0.95, Method: Composition-based stats. Identities = 7/79 (8%), Positives = 19/79 (24%) Query: 282 VNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCV 341 + + + C V + V+ ++ + + V C Sbjct: 53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACA 112 Query: 342 FQSNFQELYSGSRDCNILA 360 + + + G D Sbjct: 113 YAPSGCAIACGGLDNKCSV 131 >3FM0-A nrPDB Length = 345 Score = 155 bits (390), Expect = 5e-38, Method: Composition-based stats. Identities = 70/341 (20%), Positives = 110/341 (32%), Gaps = 53/341 (15%) Query: 49 LDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWY 108 L P G + S G D I ++ E S + CK+V S + H+ +V V W Sbjct: 22 LAWNPA-GTLLASCGGDRRIRIWGTEGDS----WICKSVLS------EGHQRTVRKVAWS 70 Query: 109 PHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKV 168 P S+SFD T +W N V E + L+A +R V Sbjct: 71 PCG-NYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSV 129 Query: 169 QLCDLKSG---SCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASG-CLI 224 + ++ C +L H Q++ V W P + +LA+AS D VKL+ C Sbjct: 130 WVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQE-LLASASYDDTVKLYREEEDDWVCCA 188 Query: 225 TLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLW-----------N 273 TL+ H V L F G L + D +R+W Sbjct: 189 TLE---------------GHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVA 233 Query: 274 SSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGE-------- 325 S + + + + + C + I V+ Sbjct: 234 CSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFS 293 Query: 326 -QITMLKGHYKTVDCCVFQSNFQ-ELYSGSRDCNILAWVPS 364 + + H + V+C + L S S D + W Sbjct: 294 LTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334 Score = 90.7 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 34/213 (15%), Positives = 75/213 (35%), Gaps = 25/213 (11%) Query: 190 LAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVN 249 ++W+P +LA+ D R+++W S ++ + H V Sbjct: 20 WFLAWNPAG-TLLASCGGDRRIRIWGTEGDSWICKSV-------------LSEGHQRTVR 65 Query: 250 GLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVF 309 + ++ G +L + D +W + + V + N K + + Sbjct: 66 KVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSV---AWAPSGNLLAT 122 Query: 310 VPYGSTIAVYTVYSG---EQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLY 366 ++ V+ V E +++L H + V V+ + + L S S D + + Sbjct: 123 CSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEED 182 Query: 367 EPVPDDDETTTKSQL-----NPAFEDAWSSSDE 394 + V +S + +P+ + S SD+ Sbjct: 183 DWVCCATLEGHESTVWSLAFDPSGQRLASCSDD 215 Score = 85.4 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 31/156 (19%), Positives = 60/156 (38%), Gaps = 14/156 (8%) Query: 245 NGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCS 304 + + L + G L + G D R+R+W ++ + + ++ ++ C Sbjct: 16 DSRCWFLAWNPAGTLLASCGGDRRIRIW--GTEGDSWICKSVLSEGHQRTVRKVAWSPCG 73 Query: 305 SEFVFVPYGSTIAVY--TVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWV 362 + + +T ++ E +T L+GH V + + L + SRD ++ W Sbjct: 74 NYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133 Query: 363 PSLYEPVPDDDETTTKSQLNPAFED----AWSSSDE 394 V ++DE S LN +D W S E Sbjct: 134 ------VDEEDEYECVSVLNSHTQDVKHVVWHPSQE 163 Score = 48.4 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 25/120 (20%), Positives = 40/120 (33%), Gaps = 10/120 (8%) Query: 278 ENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQI---TMLKGHY 334 +++LV G+V + F + I ++ I + +GH Sbjct: 2 KDSLVLLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQ 61 Query: 335 KTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDE--TTTKSQLNPAFEDAWSSS 392 +TV + L S S D W + DD E TT + N AW+ S Sbjct: 62 RTVRKVAWSPCGNYLASASFDATTCIW-----KKNQDDFECVTTLEGHENEVKSVAWAPS 116 >6ID0-T nrPDB Length = 514 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 61/311 (19%), Positives = 104/311 (33%), Gaps = 39/311 (12%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 A+ T ++ L K + H + + I Y+ S G D + +DLE Sbjct: 219 FVTGSADRTIKIWDLASGKLKLSLTGHISTVRGV-IVSTRSPYLFSCGEDKQVKCWDLEY 277 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 + +Y H +V + +P + + S D T ++WD T + Sbjct: 278 NKVIRHYHG-------------HLSAVYGLDLHPT-IDVLVTCSRDSTARIWDVRTKASV 323 Query: 136 DVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 195 + + + G+ ++L DL +G L H++ + AV Sbjct: 324 HTLSGHT--NAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLH 381 Query: 196 PRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS 255 PR+ Y A+ S D+ +K W + + HN +N L S Sbjct: 382 PRH-YTFASGSPDN-IKQWK----------------FPDGSFIQNLSGHNAIINTLTVNS 423 Query: 256 DGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCS---SEFVFVPY 312 DG L++ + M LW+ G N + V S +C S + Sbjct: 424 DG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEA 482 Query: 313 GSTIAVYTVYS 323 TI VY Sbjct: 483 DKTIKVYREDD 493 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 54/271 (19%), Positives = 94/271 (34%), Gaps = 27/271 (9%) Query: 96 DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTK 155 H V + P F + S D+T+K+WD + + + + VST+ Sbjct: 201 SGHLGWVRCIAVEP-GNQWFVTGSADRTIKIWDLASGKLKLSLTGH--ISTVRGVIVSTR 257 Query: 156 HCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 + +V+ DL+ GH + + P D +L T S DS ++WD Sbjct: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTID-VLVTCSRDSTARIWD 316 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 VR ++A + H V + + ++T D +RLW+ Sbjct: 317 VR----------------TKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV 360 Query: 276 NGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYK 335 G+ + N KK ++ V F + I + G I L GH Sbjct: 361 AGKTRVTL-----TNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNA 414 Query: 336 TVDCCVFQSNFQELYSGSRDCNILAWVPSLY 366 ++ S+ L SG+ + + W Sbjct: 415 IINTLTVNSDG-VLVSGADNGTMHLWDWRTG 444 Score = 121 bits (302), Expect = 7e-28, Method: Composition-based stats. Identities = 36/189 (19%), Positives = 66/189 (34%), Gaps = 28/189 (14%) Query: 176 GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQ 235 ++ GH + ++ P + T SAD +K+WD+ Sbjct: 194 WKLYRVISGHLGWVRCIAVEPGNQW-FVTGSADRTIKIWDLASGK--------------- 237 Query: 236 AVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGL 295 ++ + T H V G+ ++ +L + G D +++ W+ Y KV + L Sbjct: 238 -LKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLE--------YNKVIRHYHGHL 288 Query: 296 KFTVSCGCSSEF---VFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSG 352 V ST ++ V + + L GH V Q+ ++ +G Sbjct: 289 SAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITG 348 Query: 353 SRDCNILAW 361 S D I W Sbjct: 349 SHDTTIRLW 357 Score = 87.3 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 21/145 (14%), Positives = 43/145 (29%), Gaps = 5/145 (3%) Query: 225 TLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNY 284 T+ + + + H G V + +T D +++W+ ++G+ L Sbjct: 184 TMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLT 243 Query: 285 GKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQS 344 G + ++ + S + + + + I GH V Sbjct: 244 GHIST-----VRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHP 298 Query: 345 NFQELYSGSRDCNILAWVPSLYEPV 369 L + SRD W V Sbjct: 299 TIDVLVTCSRDSTARIWDVRTKASV 323 Score = 81.5 bits (199), Expect = 6e-16, Method: Composition-based stats. Identities = 40/219 (18%), Positives = 74/219 (33%), Gaps = 28/219 (12%) Query: 14 DPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDL 73 D L +ST R+ + H + T+ + E + +++G D I L+DL Sbjct: 301 DVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQ-IITGSHDTTIRLWDL 359 Query: 74 ENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ 133 + T H+ SV V +P F S S D +K W Sbjct: 360 VAGKTRVTLT-------------NHKKSVRAVVLHPRHYT-FASGSPDN-IKQWKFPDGS 404 Query: 134 TADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQE----- 188 + + + ++ S ++ G + L D ++G + Q Sbjct: 405 FIQNLSGHNAII-NTLTVNSDG--VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDS 461 Query: 189 ---ILAVSWSPRYDYILATASADSRVKLWDVRRASGCLI 224 I A ++ + + L TA AD +K++ + Sbjct: 462 ESGIFACAFD-QSESRLLTAEADKTIKVYREDDTATEET 499 Score = 56.9 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 22/172 (12%), Positives = 46/172 (26%), Gaps = 23/172 (13%) Query: 6 SARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSD 65 + R E + ++T R+ L K R H + + + P SG D Sbjct: 335 TVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRH-YTFASGSPD 393 Query: 66 GVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLK 125 I + + S H + T+ G+ S + + T+ Sbjct: 394 N-IKQWKFPDGSFIQNL-------------SGHNAIINTLTVNS--DGVLVSGADNGTMH 437 Query: 126 VWDTNTLQTADVFNFE------ETVYSHHMSPVSTKHCLVAVGTRGPKVQLC 171 +WD T + ++ + +++ Sbjct: 438 LWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489 >6EMK-B nrPDB Length = 303 Score = 152 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 52/255 (20%), Positives = 87/255 (34%), Gaps = 39/255 (15%) Query: 39 ERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVH 98 H G + ++ + + R+M++ DG I ++D+ + S Y H Sbjct: 71 FEGHRGNVTSVSFQQ-DNRWMVTSSEDGTIKVWDVRSPSIPRNYK--------------H 115 Query: 99 RYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCL 158 V V +P+ S D +++WD Q E+ +S S L Sbjct: 116 NAPVNEVVIHPNQGE-LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 Query: 159 VAVGTRGPKVQLC------DLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVK 212 A T+ + D + H I + S + LAT SAD + Sbjct: 175 AAANTK-GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH-LATCSADHTAR 232 Query: 213 LWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLW 272 +W + TLD H V F++D +L+T +D+ +RLW Sbjct: 233 VWSIDDDFKLETTLD---------------GHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 Query: 273 NSSNGENTLVNYGKV 287 + S E G Sbjct: 278 DLSTREIVRQYGGHH 292 Score = 115 bits (287), Expect = 3e-26, Method: Composition-based stats. Identities = 53/324 (16%), Positives = 111/324 (34%), Gaps = 33/324 (10%) Query: 21 AESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQS 80 + T R + +N L+I + + + + G + LYD+ ++ Sbjct: 10 YDHTIRFWEALTGVCSRTIQHSDSQVNRLEIT-NDKKLLATAGH-QNVRLYDIRTTNPNP 67 Query: 81 YYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNF 140 + + HR +V +V + D +SS D T+KVWD + + Sbjct: 68 VASF-----------EGHRGNVTSVSFQ-QDNRWMVTSSEDGTIKVWDVRSPSIPRNYKH 115 Query: 141 EETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQ-EILAVSWSPRYD 199 V + P + + R +++ DL C+H L + ++S + Sbjct: 116 NAPVNEVVIHPNQGE---LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGS 172 Query: 200 YILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLH 259 +LA A+ +W++ H + AH+ + + +SD H Sbjct: 173 -MLAAANTKGNCYVWEM----------PNHTDASHLKPVTKFRAHSTYITRILLSSDVKH 221 Query: 260 LLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVY 319 L T D+ R+W+ + + ++ + S+ V + ++ Sbjct: 222 LATCSADHTARVWSIDDDFKL----ETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 Query: 320 TVYSGEQITMLKGHYKTVDCCVFQ 343 + + E + GH+K C Sbjct: 278 DLSTREIVRQYGGHHKGAVCVALN 301 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 55/314 (17%), Positives = 105/314 (33%), Gaps = 36/314 (11%) Query: 59 MLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSS 118 ++S G D I ++ VCS H D +E +D + ++ Sbjct: 5 LVSAGYDHTIRFWEALTG----------VCSRTIQHSDSQVNRLEIT----NDKKLLATA 50 Query: 119 SFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSC 178 + ++++D T V +FE + + + + +++ D++S S Sbjct: 51 GH-QNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSI 109 Query: 179 SHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVE 238 + H + V P ++ + D +++WD+ + C L + Q Sbjct: 110 PRNYK-HNAPVNEVVIHPNQGELI-SCDRDGNIRIWDL-GENQCTHQLTPEDDTSLQ--- 163 Query: 239 SANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENT--LVNYGKVCNNSKKGLK 296 L SDG L T +W N + L K +S + Sbjct: 164 -----------SLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITR 212 Query: 297 FTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITM-LKGHYKTVDCCVFQSNFQELYSGSRD 355 +S T V+++ ++ L GH + V C F ++ L + S D Sbjct: 213 ILLSSDVKH-LATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSD 271 Query: 356 CNILAWVPSLYEPV 369 + W S E V Sbjct: 272 HYVRLWDLSTREIV 285 Score = 86.5 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 33/239 (13%), Positives = 71/239 (29%), Gaps = 23/239 (9%) Query: 156 HCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 ++ ++ + +G CS +Q ++ + +LATA + V+L+D Sbjct: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEI-TNDKKLLATAGHQN-VRLYD 59 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 +R + ++ H G V + F D ++T D +++W+ Sbjct: 60 IRTTN--------------PNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVR 105 Query: 276 NGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYK 335 + + V E + I ++ + + L Sbjct: 106 SPSIPRNY------KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDD 159 Query: 336 T-VDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSD 393 T + S+ L + + N W + T + SSD Sbjct: 160 TSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD 218 Score = 44.1 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 16/83 (19%), Positives = 29/83 (34%), Gaps = 2/83 (2%) Query: 16 LRLRRAESTRRVLGLELN-KDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLE 74 L A+ T RV ++ + K H + + Y+++ SD + L+DL Sbjct: 222 LATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFS-ADSAYLVTASSDHYVRLWDLS 280 Query: 75 NSSRQSYYTCKAVCSIGRDHPDV 97 Y ++ DV Sbjct: 281 TREIVRQYGGHHKGAVCVALNDV 303 >4BTS-AR nrPDB Length = 343 Score = 148 bits (373), Expect = 4e-36, Method: Composition-based stats. Identities = 62/361 (17%), Positives = 126/361 (34%), Gaps = 65/361 (18%) Query: 36 RDVERIHGGGINTL-----DIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSI 90 R + H + ++ E + ++SG D ++++ L + Y+ I Sbjct: 14 RGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYF------GI 67 Query: 91 GRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF-NFEETVYSHHM 149 H + V + + SSS+DKTL++WD T T F + VYS Sbjct: 68 PHKALTGHNHFVSDLALS-QENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAF 126 Query: 150 SPVSTKHCLVAVGTRGPKVQLCDLKSGSC---SHILQGHRQEILAVSWSPRYDY------ 200 SP + + + +++L ++ G C S + H + V +SP Sbjct: 127 SPDNRQ---ILSAGAEREIKLWNI-LGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQP 182 Query: 201 ---ILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDG 257 A+ D R+K+W+ + AH VN L + +G Sbjct: 183 FAPYFASVGWDGRLKVWNTNF-----------------QIRYTFKAHESNVNHLSISPNG 225 Query: 258 LHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIA 317 ++ T G D ++ +W+ N + ++ ++ ++V V + Sbjct: 226 KYIATGGKDKKLLIWDILNLTYPQREFDAGSTINQ------IAFNPKLQWVAVGTDQGVK 279 Query: 318 VYTVYS----------GEQITMLKGHYK---TVDCCVFQSNFQELYSGSRDCNILAWVPS 364 ++ + + E IT +G + + ++L++G D I + Sbjct: 280 IFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFAGFTDGVIRTFSFE 339 Query: 365 L 365 Sbjct: 340 T 340 Score = 118 bits (294), Expect = 6e-27, Method: Composition-based stats. Identities = 49/270 (18%), Positives = 102/270 (37%), Gaps = 31/270 (11%) Query: 20 RAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQ 79 + T R+ L H + ++ P + R +LS G++ I L+++ + Sbjct: 95 SWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSP-DNRQILSAGAEREIKLWNILGECKF 153 Query: 80 SYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG---------MFTSSSFDKTLKVWDTN 130 S + H V V++ P F S +D LKVW+TN Sbjct: 154 SSAE-----------KENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNTN 202 Query: 131 TLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEIL 190 Q F E+ +H +S +A G + K+ + D+ + + I Sbjct: 203 -FQIRYTFKAHESNVNH--LSISPNGKYIATGGKDKKLLIWDILNLTYPQREFDAGSTIN 259 Query: 191 AVSWSPRYDYILATASADSRVKLWDV-RRASGCLITLDQHNGKKSQAVESANTAHNGKVN 249 ++++P+ ++ D VK++++ ++ + T++ K++ + N + Sbjct: 260 QIAFNPKLQWVAV--GTDQGVKIFNLMTQSKAPVCTIEAEPITKAEGQK----GKNPQCT 313 Query: 250 GLCFTSDGLHLLTVGTDNRMRLWNSSNGEN 279 L + + G L TD +R ++ N Sbjct: 314 SLAWNALGKKLFAGFTDGVIRTFSFETSAN 343 >5WYJ-BC nrPDB Length = 817 Score = 145 bits (366), Expect = 2e-35, Method: Composition-based stats. Identities = 55/301 (18%), Positives = 106/301 (35%), Gaps = 44/301 (14%) Query: 35 DRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDH 94 D ++ H +N+LD +G ++ + D +++ +S + K + Sbjct: 380 DVEIYEGHEDLLNSLDATE-DGLWIATASKDNTAIVWRYNENSCKFDIYAKYI------- 431 Query: 95 PDVHRYSVETV----QWYPHDTGMFTSSSFDKTLKVW----DTNTLQTADVFNFEETVYS 146 H +V V ++S D T+K W T ++ + E T ++ Sbjct: 432 --GHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHA 489 Query: 147 HHMS----PVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYIL 202 H VS + A + ++ +L++G L H++ + VS+ +YD +L Sbjct: 490 HEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFC-QYDKLL 548 Query: 203 ATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLT 262 AT+S D VK+W + S V H V F + L++ Sbjct: 549 ATSSGDKTVKIWSLDTFS----------------VMKTLEGHTNAVQRCSFINKQKQLIS 592 Query: 263 VGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVY 322 G D +++W+ S+GE K + L + V + Sbjct: 593 CGADGLIKIWDCSSGECL-----KTLDGHNNRLWALSTMNDGDMIVSADADGVFQFWKDC 647 Query: 323 S 323 + Sbjct: 648 T 648 Score = 135 bits (340), Expect = 2e-32, Method: Composition-based stats. Identities = 65/350 (18%), Positives = 119/350 (34%), Gaps = 36/350 (10%) Query: 65 DGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTL 124 D + L ++E + T + SI +H + +++ + ++ +L Sbjct: 308 DQTLQLINVEEDLKNDEDTIQVTSSIAGNH-----GIIADMRYVGPELNKLALATNSPSL 362 Query: 125 KVWDTNTLQ-TADVFNFEETVYSHHMS-----PVSTKHCLVAVGTRGPKVQLCDLKSGSC 178 ++ L + +Y H + +A ++ + SC Sbjct: 363 RIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSC 422 Query: 179 S----HILQGHRQEILAVSW----SPRYDYILATASADSRVKLWDVRRASGCLITLDQHN 230 GH + AV S Y L TAS D +K W + + + + + Sbjct: 423 KFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASM------D 476 Query: 231 GKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNN 290 + + E AH +N L + + T D ++WN NGE N Sbjct: 477 VQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGE-----LEATLAN 531 Query: 291 SKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELY 350 K+GL C T+ ++++ + + L+GH V C F + ++L Sbjct: 532 HKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLI 591 Query: 351 SGSRDCNILAWVPSLYEPVPDDDETTTK----SQLNPAFEDAWSSSDEEG 396 S D I W S E + D + S +N D S+D +G Sbjct: 592 SCGADGLIKIWDCSSGECLKTLDGHNNRLWALSTMNDG--DMIVSADADG 639 Score = 124 bits (310), Expect = 8e-29, Method: Composition-based stats. Identities = 46/307 (14%), Positives = 93/307 (30%), Gaps = 40/307 (13%) Query: 72 DLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNT 131 L +A + + + H + ++ D ++S D T VW N Sbjct: 361 SLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLD-ATEDGLWIATASKDNTAIVWRYNE 419 Query: 132 LQTADVFNFEETVYSHHMSPVSTKHC-------LVAVGTRGPKVQLCDLKSGSCS----- 179 + +S ++ V + + + ++ + + S Sbjct: 420 NSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQI 479 Query: 180 -----HILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKS 234 + H ++I A+S SP D I ATAS D K+W++ Sbjct: 480 IKVSEYTRHAHEKDINALSVSP-NDSIFATASYDKTCKIWNLENGE-------------- 524 Query: 235 QAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKG 294 +E+ H + + F L T D +++W+ + K Sbjct: 525 --LEATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDT-----FSVMKTLEGHTNA 577 Query: 295 LKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSR 354 ++ + + I ++ SGE + L GH + ++ + S Sbjct: 578 VQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTLDGHNNRLWALSTMNDGDMIVSADA 637 Query: 355 DCNILAW 361 D W Sbjct: 638 DGVFQFW 644 Score = 110 bits (275), Expect = 9e-25, Method: Composition-based stats. Identities = 49/288 (17%), Positives = 98/288 (34%), Gaps = 29/288 (10%) Query: 41 IHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRY 100 H IN L + P + + D +++LEN ++ H+ Sbjct: 489 AHEKDINALSVSPND-SIFATASYDKTCKIWNLENGELEATLA-------------NHKR 534 Query: 101 SVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVA 160 + V + +D + +SS DKT+K+W +T S ++ + L++ Sbjct: 535 GLWDVSFCQYDK-LLATSSGDKTVKIWSLDTFSVMKTLEGHTN-AVQRCSFINKQKQLIS 592 Query: 161 VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRAS 220 G +++ D SG C L GH + A+S D ++ +A AD + W Sbjct: 593 CG-ADGLIKIWDCSSGECLKTLDGHNNRLWALSTMNDGD-MIVSADADGVFQFWK----- 645 Query: 221 GCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENT 280 C + +K++ + ++ +T LL + D+ MRL+N Sbjct: 646 DCTEQEIEEEQEKAKLQVEQEQSLQNYMSKGDWT--NAFLLAMTLDHPMRLFNVLKRALG 703 Query: 281 LVNYGKVCNNSKKGLKFTVSCGCSSEFV----FVPYGSTIAVYTVYSG 324 + K + F + + + + + Sbjct: 704 ESRSRQDTEEGKIEVIFNEELDQAISILNDEQLILLMKRCRDWNTNAK 751 Score = 99.2 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 46/288 (15%), Positives = 95/288 (32%), Gaps = 20/288 (6%) Query: 47 NTLDIEP--VEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVET 104 + + P + + +G I+ + I + + Sbjct: 8 KGISLNPIYAGSSAVATVSENGKILATPV-LDEINIIDLTPGSRKILHKISNEDEQEITA 66 Query: 105 VQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTR 164 ++ P D T S + LK++ T + Y ST L+AVG Sbjct: 67 LKLTP-DGQYLTYVSQAQLLKIFHLKTGKVVRSMKISSPSYILDADSTST---LLAVGGT 122 Query: 165 GPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYD---YILATASADSRVKLWDVRRASG 221 + + D+++G +H +GH I ++ + + + ++LA+ + VK+WD+ Sbjct: 123 DGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDL-VKRK 181 Query: 222 CLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTL 281 CL TL +H ++ L+LL+ G D+ + LW+ + + Sbjct: 182 CLHTLQEHTSAVRGLDIIEVPDNDEP---------SLNLLSGGRDDIINLWDFNMKKKCK 232 Query: 282 VNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITM 329 + N + F + + SG + Sbjct: 233 LLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKR 280 Score = 82.3 bits (201), Expect = 4e-16, Method: Composition-based stats. Identities = 16/156 (10%), Positives = 43/156 (27%), Gaps = 17/156 (10%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 + T ++ LE + H G+ + + + + + D + ++ L+ Sbjct: 506 FATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYD-KLLATSSGDKTVKIWSLDT 564 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 S + H +V+ + S D +K+WD ++ + Sbjct: 565 FS-------------VMKTLEGHTNAVQRCSFINKQK-QLISCGADGLIKIWDCSSGECL 610 Query: 136 DVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLC 171 + + ++ Q Sbjct: 611 KTLDGHNNRLWALSTM--NDGDMIVSADADGVFQFW 644 Score = 55.3 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 43/241 (17%), Positives = 77/241 (31%), Gaps = 45/241 (18%) Query: 146 SHHMSPVSTKHCLVAVGTRGP---------KVQLCDLKSGSCSHILQGHR------QEIL 190 ++P+ VA + ++ + DL GS + H+ QEI Sbjct: 9 GISLNPIYAGSSAVATVSENGKILATPVLDEINIIDLTPGSRKIL---HKISNEDEQEIT 65 Query: 191 AVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNG 250 A+ +P Y L S +K++ ++ + V S + + Sbjct: 66 ALKLTPDGQY-LTYVSQAQLLKIFHLKTG---------------KVVRSMKISSPSYI-- 107 Query: 251 LCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFV 310 L S L GTD + + + NG + + K + LKF + Sbjct: 108 LDADSTSTLLAVGGTDGSIIVVDIENGY--ITHSFKGHGGTISSLKFYGQLNSKIWLLAS 165 Query: 311 P-YGSTIAVYTVYSGEQITMLKGHYKTVDCCVF--QSNFQE----LYSGSRDCNILAWVP 363 + V+ + + + L+ H V + E L SG RD I W Sbjct: 166 GDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDF 225 Query: 364 S 364 + Sbjct: 226 N 226 >4AEZ-A nrPDB Length = 401 Score = 145 bits (365), Expect = 3e-35, Method: Composition-based stats. Identities = 57/294 (19%), Positives = 118/294 (40%), Gaps = 38/294 (12%) Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLV 159 Y + + W + + + ++ + VW+ ++ + + +E+ Y + S + Sbjct: 94 YYLNLLDWSNLN---VVAVALERNVYVWNADSGSVSALAETDESTYVASVK-WSHDGSFL 149 Query: 160 AVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRA 219 +VG V + D++S + + GH+ + +SW+ ++L++ S + DVR A Sbjct: 150 SVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWN---RHVLSSGSRSGAIHHHDVRIA 206 Query: 220 SGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEN 279 + + TL H+ +V GL + SDGL L + G DN +++W++ + Sbjct: 207 NHQIGTLQ---------------GHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIP 251 Query: 280 TLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGST---IAVYTVYSGEQITMLKGHYKT 336 N +K C S + G+ I + +G ++ + + Sbjct: 252 KFTK-----TNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQ- 305 Query: 337 VDCCVFQSNFQELYS--GSRDCNILAWVPSL-----YEPVPDDDETTTKSQLNP 383 V ++ + +E+ S G D N+ W S +P D S L+P Sbjct: 306 VTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSP 359 Score = 81.9 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 40/261 (15%), Positives = 83/261 (31%), Gaps = 35/261 (13%) Query: 26 RVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCK 85 + +E H + L + SG G I +D+ ++ Q Sbjct: 159 DIYDVESQTKLRTMAGHQARVGCLSWN---RHVLSSGSRSGAIHHHDVRIANHQI----- 210 Query: 86 AVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVY 145 H V + W D S D +++WD + Sbjct: 211 -------GTLQGHSSEVCGLAWRS-DGLQLASGGNDNVVQIWDARS-SIPKFTKTNHNAA 261 Query: 146 SHHMSPVSTKHCLVAV--GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILA 203 ++ + L+A GT ++ + +G+ + + Q + ++ WSP I++ Sbjct: 262 VKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQ-VTSLIWSPHSKEIMS 320 Query: 204 T-ASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLT 262 T D+ + +W + + AH+ +V + DG L T Sbjct: 321 THGFPDNNLSIWSYSSSG--------------LTKQVDIPAHDTRVLYSALSPDGRILST 366 Query: 263 VGTDNRMRLWNSSNGENTLVN 283 +D ++ W +G++ Sbjct: 367 AASDENLKFWRVYDGDHVKRP 387 Score = 62.2 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 23/179 (12%), Positives = 56/179 (31%), Gaps = 19/179 (10%) Query: 5 LSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGG- 63 L+ R GL+ L ++ ++ + + + H + + P + + +GG Sbjct: 223 LAWRSDGLQ--LASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGG 280 Query: 64 -SDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSF-D 121 D I ++ R + V ++ W PH + ++ F D Sbjct: 281 TMDKQIHFWNAATG--------------ARVNTVDAGSQVTSLIWSPHSKEIMSTHGFPD 326 Query: 122 KTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSH 180 L +W ++ + S +S +++ ++ + G Sbjct: 327 NNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHVK 385 >3JB9-L nrPDB Length = 340 Score = 145 bits (365), Expect = 3e-35, Method: Composition-based stats. Identities = 58/322 (18%), Positives = 113/322 (35%), Gaps = 39/322 (12%) Query: 41 IHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRY 100 H + +P G Y SGG D I+L+++ + + + Sbjct: 48 GHTAEVLVARFDP-SGSYFASGGMDRQILLWNVFGDVK------------NYGVLNGCKG 94 Query: 101 SVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVA 160 ++ +QW D+ + SS D L WD + Q V + + + L+ Sbjct: 95 AITDLQWS-RDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGV-VNALDVLKVGSELLT 152 Query: 161 VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRAS 220 + +++ D +S C ++ + + AV+ + + + D +K+WD+R + Sbjct: 153 SVSDDCTMKVWDSRSKDCIKTIEE-KYPLTAVAIAQQGTQVFI-GGIDGAIKIWDLRN-N 209 Query: 221 GCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS----SN 276 C L H + L + DG LL+ DN +R+++ S Sbjct: 210 HCSHVLK---------------GHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASA 254 Query: 277 GENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKT 336 + G + L S + V++ +G+ +L GH + Sbjct: 255 QRQLQIFEGAIHGQEHNLLG-VAWSRNSRFVGAGSSDKNVYVWS-ATGDLRYVLPGHEGS 312 Query: 337 VDCCVFQSNFQELYSGSRDCNI 358 V+ F + + S S D I Sbjct: 313 VNHVDFHPHQDIILSCSSDRTI 334 Score = 108 bits (269), Expect = 5e-24, Method: Composition-based stats. Identities = 45/308 (14%), Positives = 98/308 (31%), Gaps = 32/308 (10%) Query: 66 GVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLK 125 I + D + S + ++ H V ++ P + F S D+ + Sbjct: 17 KRIRIQDSSLITEGSVLQRTSDLNVPNLQMFGHTAEVLVARFDPSGS-YFASGGMDRQIL 75 Query: 126 VWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGH 185 +W+ + + S +V + + D SG +GH Sbjct: 76 LWNV-FGDVKNYGVLNGCKGAITDLQWSRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGH 134 Query: 186 RQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHN 245 + A+ +L + S D +K+WD R C+ T+++ Sbjct: 135 AGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKD-CIKTIEEK---------------- 177 Query: 246 GKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSS 305 + + G + G D +++W+ N + V K + S Sbjct: 178 YPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCS-----HVLKGHKDIITSLAISKDGS 232 Query: 306 EFVFVPYGSTIAVYTVY----SGEQITMLKG----HYKTVDCCVFQSNFQELYSGSRDCN 357 + +T+ ++ V + Q+ + +G + + N + + +GS D N Sbjct: 233 SLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKN 292 Query: 358 ILAWVPSL 365 + W + Sbjct: 293 VYVWSATG 300 Score = 98.8 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 43/277 (15%), Positives = 87/277 (31%), Gaps = 46/277 (16%) Query: 7 ARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDG 66 +R + + + +++ + + H G +N LD+ V + S D Sbjct: 102 SRDSRV---VYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDC 158 Query: 67 VIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKV 126 + ++D + K Y + V T +F D +K+ Sbjct: 159 TMKVWDSRSKDCIKTIEEK--------------YPLTAVAIAQQGTQVFIGG-IDGAIKI 203 Query: 127 WDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLK----SGSCSHIL 182 WD + V + + +S + + V++ D+K + I Sbjct: 204 WDLRNNHCSHVLKGHKDII--TSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIF 261 Query: 183 Q----GHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVE 238 + G +L V+WS R + S+D V +W + + Sbjct: 262 EGAIHGQEHNLLGVAWS-RNSRFVGAGSSDKNVYVWS-----------------ATGDLR 303 Query: 239 SANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 H G VN + F +L+ +D + L + Sbjct: 304 YVLPGHEGSVNHVDFHPHQDIILSCSSDRTIFLGELN 340 Score = 74.2 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 34/172 (19%), Positives = 57/172 (33%), Gaps = 5/172 (2%) Query: 204 TASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTV 263 +A+ VK ++ +S H +V F G + + Sbjct: 9 SATNGHLVKRIRIQDSSLITEGSVLQRTSDLNVPNLQMFGHTAEVLVARFDPSGSYFASG 68 Query: 264 GTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYS 323 G D ++ LWN + NYG V N K + S + + + S Sbjct: 69 GMDRQILLWNV---FGDVKNYG-VLNGCKGAITDLQWSRDSRVVYCSSSDTHLMSWDAVS 124 Query: 324 GEQITMLKGHYKTVDCCVFQSNFQELYSG-SRDCNILAWVPSLYEPVPDDDE 374 G++I KGH V+ EL + S DC + W + + +E Sbjct: 125 GQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIEE 176 >5Z56-q nrPDB Length = 504 Score = 145 bits (364), Expect = 4e-35, Method: Composition-based stats. Identities = 59/304 (19%), Positives = 105/304 (34%), Gaps = 47/304 (15%) Query: 14 DPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDL 73 + + A+ V + + H + ++ P + + S D I ++ + Sbjct: 235 NKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQD-LVFSASPDATIRIWSV 293 Query: 74 ENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ 133 N+S H +V + + SSS D+ D T + Sbjct: 294 PNASCVQVVR-------------AHESAVTGLSLHATG-DYLLSSSDDQYWAFSDIQTGR 339 Query: 134 TADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVS 193 E + S + + GT ++++ DLK + GH I +++ Sbjct: 340 VLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIA 399 Query: 194 WSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCF 253 +S Y LATA+ DS VKLWD+R K + ++ +N +V L F Sbjct: 400 FS-ENGYYLATAADDSSVKLWDLR---------------KLKNFKTLQLDNNFEVKSLIF 443 Query: 254 TSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYG 313 G +L GTD ++ + C + L FT G ++ F + Sbjct: 444 DQSGTYLALGGTDVQIYI----------------CKQWTEILHFTEHSGLTTGVAFGHHA 487 Query: 314 STIA 317 IA Sbjct: 488 KFIA 491 Score = 124 bits (311), Expect = 7e-29, Method: Composition-based stats. Identities = 41/203 (20%), Positives = 71/203 (34%), Gaps = 20/203 (9%) Query: 159 VAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRR 218 + G V + D S L+GH +++ +V + P D ++ +AS D+ +++W V Sbjct: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQD-LVFSASPDATIRIWSVPN 295 Query: 219 ASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 AS + AH V GL + G +LL+ D W S+ + Sbjct: 296 ASCVQVV----------------RAHESAVTGLSLHATGDYLLSSSDDQY---WAFSDIQ 336 Query: 279 NTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVD 338 V S L F S I ++ + + GH + Sbjct: 337 TGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPIT 396 Query: 339 CCVFQSNFQELYSGSRDCNILAW 361 F N L + + D ++ W Sbjct: 397 SIAFSENGYYLATAADDSSVKLW 419 Score = 108 bits (270), Expect = 3e-24, Method: Composition-based stats. Identities = 45/263 (17%), Positives = 85/263 (32%), Gaps = 35/263 (13%) Query: 13 EDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYD 72 +D + ++T R+ + V R H + L + G Y+LS D D Sbjct: 276 QDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHAT-GDYLLSSSDDQYWAFSD 334 Query: 73 LENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTL 132 ++ + T + S+ Q++P D +F + + D +K+WD Sbjct: 335 IQTGRVLTKVTDETSGC-----------SLTCAQFHP-DGLIFGTGTMDSQIKIWDLKER 382 Query: 133 QTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQG-HRQEILA 191 F S +A V+L DL+ LQ + E+ + Sbjct: 383 TNVANFPGHSGPI--TSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKS 440 Query: 192 VSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGL 251 + + Y LA D ++ + K T H+G G+ Sbjct: 441 LIFDQSGTY-LALGGTDVQIYI------------------CKQWTEILHFTEHSGLTTGV 481 Query: 252 CFTSDGLHLLTVGTDNRMRLWNS 274 F + + G D ++ ++ Sbjct: 482 AFGHHAKFIASTGMDRSLKFYSL 504 Score = 65.7 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 26/126 (20%), Positives = 46/126 (36%), Gaps = 3/126 (2%) Query: 273 NSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKG 332 S + G + L + +++ + + V+ S + + LKG Sbjct: 203 ELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKG 262 Query: 333 HYKTVDCCVFQSNFQELYSGSRDCNILAWVP---SLYEPVPDDDETTTKSQLNPAFEDAW 389 H K V VF + ++S S D I W S + V + T L+ + Sbjct: 263 HTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLL 322 Query: 390 SSSDEE 395 SSSD++ Sbjct: 323 SSSDDQ 328 >6Q8F-A nrPDB Length = 514 Score = 142 bits (358), Expect = 2e-34, Method: Composition-based stats. Identities = 42/188 (22%), Positives = 77/188 (40%), Gaps = 13/188 (6%) Query: 180 HILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVES 239 HI G + + +SP Y L T S D +++W+ T K QA ++ Sbjct: 209 HIKFGQKSHVECARFSPDGQY-LVTGSVDGFIEVWN-------FTTGKIRKDLKYQAQDN 260 Query: 240 ANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTV 299 + V +CF+ D L T D ++++W +G+ L + + + L F+ Sbjct: 261 FMMM-DDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQC-LRRFERAHSKGVTCLSFSK 318 Query: 300 SCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNIL 359 SS+ + + TI ++ + SG+ + +GH V+ F + + S S D + Sbjct: 319 D---SSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVK 375 Query: 360 AWVPSLYE 367 W E Sbjct: 376 IWNMKTTE 383 Score = 141 bits (356), Expect = 4e-34, Method: Composition-based stats. Identities = 58/332 (17%), Positives = 106/332 (31%), Gaps = 71/332 (21%) Query: 85 KAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETV 144 K + R + VE ++ P D + S D ++VW+ T + ++ Sbjct: 201 KFPTQLSRHIKFGQKSHVECARFSP-DGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQD 259 Query: 145 YSHHMSPV------STKHCLVAVGTRGPKVQLCDLKSGSCSHILQ-GHRQEILAVSWSPR 197 M S ++A G + K+++ ++SG C + H + + +S+S Sbjct: 260 NFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKD 319 Query: 198 YDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDG 257 IL +AS D +++ G KS H+ VN FT DG Sbjct: 320 SSQIL-SASFDQTIRIH----------------GLKSGKTLKEFRGHSSFVNEATFTQDG 362 Query: 258 LHLLTVGTDNRMRLWNSSNGENTLVNYGK------------------------VCNNSKK 293 ++++ +D +++WN E + VCN S Sbjct: 363 HYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNT 422 Query: 294 GLKFT-------------------VSCGCSS---EFVFVPYGSTIAVYTVYSGEQITMLK 331 + V C S V + ++ +G+ L Sbjct: 423 VVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLT 482 Query: 332 GHYKTVDCCVFQSNFQELYSGSRDCNILAWVP 363 H K V + + + S D + W P Sbjct: 483 VHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP 514 Score = 48.0 bits (112), Expect = 7e-06, Method: Composition-based stats. Identities = 16/114 (14%), Positives = 34/114 (29%), Gaps = 8/114 (7%) Query: 273 NSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKG 332 + + + K ++ V I V+ +G+ LK Sbjct: 196 DVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKY 255 Query: 333 HYK--------TVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTK 378 + V C F + + L +G++D I W + + + +K Sbjct: 256 QAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSK 309 >5UZ7-B nrPDB Length = 351 Score = 142 bits (358), Expect = 2e-34, Method: Composition-based stats. Identities = 54/328 (16%), Positives = 112/328 (34%), Gaps = 38/328 (11%) Query: 36 RDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP 95 R R H I + + R ++S DG ++++D +++ Sbjct: 59 RRTLRGHLAKIYAMHW-GTDSRLLVSASQDGKLIIWDSYTTNK-------------VHAI 104 Query: 96 DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVS-T 154 + V T + P D +++ T + + E ++ ++S Sbjct: 105 PLRSSWVMTCAYAP-SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL 163 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLW 214 + + L D+++G + GH +++++S +P + + + D+ KLW Sbjct: 164 DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR-LFVSGACDASAKLW 222 Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 DVR T H +N +CF +G T D RL++ Sbjct: 223 DVREG----------------MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDL 266 Query: 275 SNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGST-IAVYTVYSGEQITMLKGH 333 + + +++ +VS S + Y V+ ++ +L GH Sbjct: 267 RADQELMT----YSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGH 322 Query: 334 YKTVDCCVFQSNFQELYSGSRDCNILAW 361 V C + + +GS D + W Sbjct: 323 DNRVSCLGVTDDGMAVATGSWDSFLKIW 350 Score = 114 bits (284), Expect = 9e-26, Method: Composition-based stats. Identities = 38/213 (17%), Positives = 79/213 (37%), Gaps = 16/213 (7%) Query: 3 GFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSG 62 G+LS + ++ + ++T + +E + H G + +L + P + R +SG Sbjct: 155 GYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAP-DTRLFVSG 213 Query: 63 GSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDK 122 D L+D+ + R H + + ++P+ F + S D Sbjct: 214 ACDASAKLWDVREG-------------MCRQTFTGHESDINAICFFPNGNA-FATGSDDA 259 Query: 123 TLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHIL 182 T +++D Q ++ + + S L+ G + D + +L Sbjct: 260 TCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL 319 Query: 183 QGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 GH + + +AT S DS +K+W+ Sbjct: 320 AGHDNRVSCLGV-TDDGMAVATGSWDSFLKIWN 351 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 54/283 (19%), Positives = 94/283 (33%), Gaps = 45/283 (15%) Query: 20 RAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQ 79 + + + + T P G Y+ GG D + +Y+L+ Sbjct: 85 SQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP-SGNYVACGGLDNICSIYNLKTREGN 143 Query: 80 SYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN 139 H + ++ D +SS D T +WD T Q F Sbjct: 144 VRV---------SRELAGHTGYLSCCRF--LDDNQIVTSSGDTTCALWDIETGQQTTTFT 192 Query: 140 -FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRY 198 V S ++P + L G +L D++ G C GH +I A+ + P Sbjct: 193 GHTGDVMSLSLAPDTR---LFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNG 249 Query: 199 DYILATASADSRVKLWDVRRASG----------CLITLDQHNGKKSQAVESAN------- 241 + AT S D+ +L+D+R C IT + + + Sbjct: 250 NA-FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 308 Query: 242 -----------TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 H+ +V+ L T DG+ + T D+ +++WN Sbjct: 309 DALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 351 Score = 83.8 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 36/203 (17%), Positives = 73/203 (35%), Gaps = 21/203 (10%) Query: 180 HILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVES 239 L+GH +I A+ W +L +AS D ++ +WD + + Sbjct: 60 RTLRGHLAKIYAMHWGTDSR-LLVSASQDGKLIIWDSYTTNKVHAIPLR----------- 107 Query: 240 ANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTV 299 + V + G ++ G DN ++N E + ++ ++ Sbjct: 108 -----SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSC--C 160 Query: 300 SCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNIL 359 ++ V +T A++ + +G+Q T GH V + + SG+ D + Sbjct: 161 RFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAK 220 Query: 360 AWVPSLYEPVPDDDETTTKSQLN 382 W + E + T +S +N Sbjct: 221 LW--DVREGMCRQTFTGHESDIN 241 Score = 64.6 bits (155), Expect = 7e-11, Method: Composition-based stats. Identities = 23/141 (16%), Positives = 48/141 (34%), Gaps = 16/141 (11%) Query: 231 GKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNN 290 G+ H K+ + + +D L++ D ++ +W+S KV Sbjct: 52 GRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYT-------TNKVHAI 104 Query: 291 SKKGLKFTVSC---GCSSEFVFVPYGSTIAVYTVYSGE----QITMLKGHYKTVDCCVFQ 343 + + ++C + + ++Y + + E L GH + CC F Sbjct: 105 PLRS-SWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL 163 Query: 344 SNFQELYSGSRDCNILAWVPS 364 + Q + + S D W Sbjct: 164 DDNQ-IVTSSGDTTCALWDIE 183 >4E5Z-B nrPDB Length = 436 Score = 140 bits (353), Expect = 9e-34, Method: Composition-based stats. Identities = 69/331 (20%), Positives = 122/331 (36%), Gaps = 43/331 (12%) Query: 47 NTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQ 106 +L P + G G I+L++ + ++ S+ ++ Sbjct: 123 TSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAG-----------GSITGLK 171 Query: 107 WYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMS-PVSTKHCLVAVGTRG 165 + P +T F +SS + T ++ D VF +T+ S VS +V G Sbjct: 172 FNPLNTNQFYASSMEGTTRLQDF-KGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNV 230 Query: 166 PKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLIT 225 V L ++ L+ H++++ V+ +P D+ LATAS D VK+WD+R+ G Sbjct: 231 GNVILLNMDGKELW-NLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRG---- 285 Query: 226 LDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENT--LVN 283 +A + H VN CF+ DG LLT + +R++++S + L+ Sbjct: 286 ---------KASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIP 336 Query: 284 YGKVCNNSKKGLKFTVSC----------GCSSEFVFVPYG-STIAVYTVYSGEQI-TMLK 331 + +K + PY TI V+ SG+ + + Sbjct: 337 HPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYD 396 Query: 332 GHYKTVDCC-VFQSNFQELYSGSRDCNILAW 361 + F L S +IL W Sbjct: 397 PESSGISSLNEFNPMGDTLASA-MGYHILIW 426 Score = 68.0 bits (164), Expect = 7e-12, Method: Composition-based stats. Identities = 26/197 (13%), Positives = 66/197 (33%), Gaps = 29/197 (14%) Query: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 R+H + + + P ++ + D + ++DL ++ + + HR Sbjct: 247 RMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASF----------LYSLPHR 296 Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVS----TK 155 + V + P D ++ ++V+ + + H++P+ + Sbjct: 297 HPVNAACFSP-DGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPR 355 Query: 156 HCLVAVGTR-GPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYI------------L 202 + L+ VG P + C + G+ +++ + P I L Sbjct: 356 YNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTL 415 Query: 203 ATASADSRVKLWDVRRA 219 A+A + +W + Sbjct: 416 ASA-MGYHILIWSEQEE 431 Score = 66.5 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 40/275 (14%), Positives = 82/275 (29%), Gaps = 34/275 (12%) Query: 96 DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDT-NTLQTADVFNFEETVYSHHMSPVST 154 +H++ + W G+ L D+ LQ A F+ T + H T Sbjct: 80 TLHQHKLGRASWPSVQQGL-----QQSFLHTLDSYRILQKAAPFDRRATSLAWH----PT 130 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQGHR--QEILAVSWSPRYDYILATASADSRVK 212 VAVG++G + L + ++G I + ++P +S + + Sbjct: 131 HPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTR 190 Query: 213 LWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLW 272 L D + V +++ N L ++ ++T DN + Sbjct: 191 LQDFKGN--------------ILRVFASSDTINIWFCSLDVSASSRMVVTG--DNVGNVI 234 Query: 273 NSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLK- 331 + L N ++ + C T+ ++ + Sbjct: 235 LLNMDGKELWNL-RMHKKKVTHVALNPCCDW--FLATASVDQTVKIWDLRQVRGKASFLY 291 Query: 332 --GHYKTVDCCVFQSNFQELYSGSRDCNILAWVPS 364 H V+ F + L + + I + S Sbjct: 292 SLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSAS 326 >4PSX-B nrPDB Length = 401 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 45/240 (18%), Positives = 93/240 (38%), Gaps = 15/240 (6%) Query: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 + H L + +LSG D + L+++ + + R D+H Sbjct: 157 KFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTK--------PVRTWNDLHS 208 Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTN-TLQTADVFNFEETVYSHHMSPVSTKHCL 158 + +W+ + +F + S D LK+ D T D + + S S+ L Sbjct: 209 DIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSS--NL 266 Query: 159 VAVGTRGPKVQLCDLKS-GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 +A V L DL++ H + GH + + +S D ++ ++ +D+R+ +WD++ Sbjct: 267 LAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK 326 Query: 218 RASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLL-TVGTDNRMRLWNSSN 276 + D +G + + H VN L+ + +N +++W S+ Sbjct: 327 QIGAEQTPDDAEDGVPELIM--VHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSH 384 Score = 81.9 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 47/250 (18%), Positives = 87/250 (34%), Gaps = 23/250 (9%) Query: 130 NTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEI 189 + ++ + EE + P +VA L G L+ H+ Sbjct: 107 SNIRITAKYEHEEEITRARYMP--QDPNIVATINGQGTTFLYSRSEG-LQSTLKFHKDNG 163 Query: 190 LAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVN 249 A+S+S L + S D V LW+V G ++ V + N H+ +N Sbjct: 164 YALSFSTLVKGRLLSGSDDHTVALWEVGSG-----------GDPTKPVRTWNDLHSDIIN 212 Query: 250 GLCFTS-DGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFV 308 + + + TV D+ +++ + T+ C L F+ S+ Sbjct: 213 DNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVK--CPQPFNTLAFSHHS--SNLLA 268 Query: 309 FVPYGSTIAVYTVYS-GEQITMLKGHYKTVDCCVFQSNFQ-ELYSGSRDCNILAWVPS-- 364 S + +Y + + E + + GH V+ F ++ + S D ++ W Sbjct: 269 AAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQI 328 Query: 365 LYEPVPDDDE 374 E PDD E Sbjct: 329 GAEQTPDDAE 338 >4LG8-A nrPDB Length = 354 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 59/304 (19%), Positives = 105/304 (34%), Gaps = 47/304 (15%) Query: 14 DPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDL 73 + + A+ V + + H + ++ P + + S D I ++ + Sbjct: 85 NKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQD-LVFSASPDATIRIWSV 143 Query: 74 ENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ 133 N+S H +V + + SSS D+ D T + Sbjct: 144 PNASCVQVVR-------------AHESAVTGLSLHATG-DYLLSSSDDQYWAFSDIQTGR 189 Query: 134 TADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVS 193 E + S + + GT ++++ DLK + GH I +++ Sbjct: 190 VLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIA 249 Query: 194 WSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCF 253 +S Y LATA+ DS VKLWD+R K + ++ +N +V L F Sbjct: 250 FS-ENGYYLATAADDSSVKLWDLR---------------KLKNFKTLQLDNNFEVKSLIF 293 Query: 254 TSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYG 313 G +L GTD ++ + C + L FT G ++ F + Sbjct: 294 DQSGTYLALGGTDVQIYI----------------CKQWTEILHFTEHSGLTTGVAFGHHA 337 Query: 314 STIA 317 IA Sbjct: 338 KFIA 341 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 41/203 (20%), Positives = 71/203 (34%), Gaps = 20/203 (9%) Query: 159 VAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRR 218 + G V + D S L+GH +++ +V + P D ++ +AS D+ +++W V Sbjct: 87 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQD-LVFSASPDATIRIWSVPN 145 Query: 219 ASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 AS + AH V GL + G +LL+ D W S+ + Sbjct: 146 ASCVQVV----------------RAHESAVTGLSLHATGDYLLSSSDDQY---WAFSDIQ 186 Query: 279 NTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVD 338 V S L F S I ++ + + GH + Sbjct: 187 TGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPIT 246 Query: 339 CCVFQSNFQELYSGSRDCNILAW 361 F N L + + D ++ W Sbjct: 247 SIAFSENGYYLATAADDSSVKLW 269 Score = 104 bits (259), Expect = 6e-23, Method: Composition-based stats. Identities = 45/263 (17%), Positives = 85/263 (32%), Gaps = 35/263 (13%) Query: 13 EDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYD 72 +D + ++T R+ + V R H + L + G Y+LS D D Sbjct: 126 QDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHAT-GDYLLSSSDDQYWAFSD 184 Query: 73 LENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTL 132 ++ + T + S+ Q++P D +F + + D +K+WD Sbjct: 185 IQTGRVLTKVTDETSGC-----------SLTCAQFHP-DGLIFGTGTMDSQIKIWDLKER 232 Query: 133 QTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQG-HRQEILA 191 F S +A V+L DL+ LQ + E+ + Sbjct: 233 TNVANFPGHSGPI--TSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKS 290 Query: 192 VSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGL 251 + + Y LA D ++ + K T H+G G+ Sbjct: 291 LIFDQSGTY-LALGGTDVQIYI------------------CKQWTEILHFTEHSGLTTGV 331 Query: 252 CFTSDGLHLLTVGTDNRMRLWNS 274 F + + G D ++ ++ Sbjct: 332 AFGHHAKFIASTGMDRSLKFYSL 354 Score = 63.4 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 26/126 (20%), Positives = 46/126 (36%), Gaps = 3/126 (2%) Query: 273 NSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKG 332 S + G + L + +++ + + V+ S + + LKG Sbjct: 53 ELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKG 112 Query: 333 HYKTVDCCVFQSNFQELYSGSRDCNILAWVP---SLYEPVPDDDETTTKSQLNPAFEDAW 389 H K V VF + ++S S D I W S + V + T L+ + Sbjct: 113 HTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLL 172 Query: 390 SSSDEE 395 SSSD++ Sbjct: 173 SSSDDQ 178 >5OQL-L nrPDB Length = 557 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 47/314 (14%), Positives = 101/314 (32%), Gaps = 36/314 (11%) Query: 69 VLYDLENSSRQSYYTCK-AVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVW 127 + + T + I V + T + + ++++ Sbjct: 25 RYWRSFKKQKSHTSTANWPISHISFPASLGTTALVSSSLVAAAKTNDLFAVTAGPRVEIF 84 Query: 128 DTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQG--- 184 + H + ++ G ++Q+ D+ G+ + IL+ Sbjct: 85 SIRKREPLKTI--GRFDSEAHCGEIRPDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHI 142 Query: 185 HRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAH 244 H+Q + WSP L + S D V+LWD+ S T H Sbjct: 143 HKQPVWVTKWSPTELTTLMSCSDDKTVRLWDL----------------PSNDPTRLFTGH 186 Query: 245 NGKVNGLCF---TSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSC 301 V F +++ L++ D +R+W++ ++ + ++ + Sbjct: 187 TDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTF-----KHADPIEDVLPL 241 Query: 302 GCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA- 360 S + G+ I+V + + + + ++ H KTV S + + SGS D ++ Sbjct: 242 P-SGTTLLAASGNAISVLDLVAAKPLRLITNHQKTVTSLSLASQGRRVVSGSLDGHVKVF 300 Query: 361 ----WVPSLYEPVP 370 W P Sbjct: 301 ETTSWNVVAGAKYP 314 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 46/248 (18%), Positives = 87/248 (35%), Gaps = 42/248 (16%) Query: 39 ERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVH 98 H G I +GR +++G G + ++D+ + ++ +H Sbjct: 100 SEAHCGEIRP------DGRVLVAGEDTGRMQVFDV----------GQGTRAVILKTWHIH 143 Query: 99 RYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTKHC 157 + V +W P + S S DKT+++WD + +F + V P S Sbjct: 144 KQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSN 203 Query: 158 LVAVGTRGPKVQLCDLKS-GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 L+ G+ V++ D ++ G + H I V P +LA + + + + D+ Sbjct: 204 LLVSGSYDETVRVWDARAPGGAVMTFK-HADPIEDVLPLPSGTTLLAASG--NAISVLDL 260 Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL----- 271 A + T H V L S G +++ D +++ Sbjct: 261 VAAKPLRLI----------------TNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTS 304 Query: 272 WNSSNGEN 279 WN G Sbjct: 305 WNVVAGAK 312 Score = 97.7 bits (241), Expect = 9e-21, Method: Composition-based stats. Identities = 37/210 (17%), Positives = 84/210 (40%), Gaps = 22/210 (10%) Query: 41 IHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRY 100 IH + P E ++S D + L+DL ++ +T H Sbjct: 142 IHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTG-------------HTD 188 Query: 101 SVETVQWYP--HDTGMFTSSSFDKTLKVWDTNT-LQTADVFNFEETVYSHHMSPVSTKHC 157 V + P ++ + S S+D+T++VWD F + + P+ + Sbjct: 189 YVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIEDV--LPLPSGTT 246 Query: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 L+A G + + DL + ++ H++ + ++S + + ++ + S D VK+++ Sbjct: 247 LLAA--SGNAISVLDLVAAKPLRLITNHQKTVTSLSLASQGRRVV-SGSLDGHVKVFET- 302 Query: 218 RASGCLITLDQHNGKKSQAVESANTAHNGK 247 + + + S +V +A +H+ + Sbjct: 303 TSWNVVAGAKYPSPILSLSVITAGASHDDR 332 Score = 70.3 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 35/199 (17%), Positives = 64/199 (32%), Gaps = 38/199 (19%) Query: 20 RAESTRRVLGLELNKDRDVERIHGGGINTLDIEP--VEGRYMLSGGSDGVIVLYDLENSS 77 + T R+ L N + H + P ++SG D + ++D Sbjct: 164 SDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDAR--- 220 Query: 78 RQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADV 137 G H +E V P T + +S + V D + + Sbjct: 221 ----------APGGAVMTFKHADPIEDVLPLPSGTTLLAASG--NAISVLDLVAAKPLRL 268 Query: 138 FN-FEETVYSHHMSPVSTKHCLVAVGTRGPKVQL-----CDLKSGSCSHILQGHRQEILA 191 ++TV S ++ + V G+ V++ ++ +G+ IL+ Sbjct: 269 ITNHQKTVTSLSLASQGRR---VVSGSLDGHVKVFETTSWNVVAGAKY------PSPILS 319 Query: 192 VSWSPRYDYILATASADSR 210 +S I A AS D R Sbjct: 320 LSV------ITAGASHDDR 332 Score = 38.0 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 24/154 (15%), Positives = 47/154 (30%), Gaps = 18/154 (11%) Query: 19 RRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSR 78 + T RV + H I + P + + G I + DL + Sbjct: 208 GSYDETVRVWDARAPGGAVMTFKHADPIEDVLPLPSGTTLLAASG--NAISVLDLVAAKP 265 Query: 79 QSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF 138 T H+ +V ++ + S S D +KV++T + Sbjct: 266 LRLIT-------------NHQKTVTSLSLASQGRRV-VSGSLDGHVKVFETTSWNVVAGA 311 Query: 139 NFEETVYSHH--MSPVSTKHCLVAVGTRGPKVQL 170 + + S + S +AVG + + + Sbjct: 312 KYPSPILSLSVITAGASHDDRHLAVGMQSGVLSI 345 >5L9T-R nrPDB Length = 493 Score = 135 bits (339), Expect = 3e-32, Method: Composition-based stats. Identities = 62/329 (18%), Positives = 110/329 (33%), Gaps = 37/329 (11%) Query: 52 EPVEGR----YMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQW 107 P +G Y LS S+ L L + + + K + + + V W Sbjct: 138 SPDDGNDVSPYSLSPVSNKSQKL--LRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDW 195 Query: 108 YPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPK 167 + S + +W T Q + + S S + LVAVGT Sbjct: 196 SSLN---VLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGF 252 Query: 168 VQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLD 227 VQ+ D +G +L+GH + A++W+ L++ S D + D+R Sbjct: 253 VQIWDAAAGKKLSMLEGHTARVGALAWNAEQ---LSSGSRDRMILQRDIRT--------- 300 Query: 228 QHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKV 287 E H +V GL +++D L + G DN++ +WN S+ + Sbjct: 301 -----PPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHL 355 Query: 288 CNNSKKGLKFTVSCGCSSEFVFVPYGST---IAVYTVYSGEQITMLKGHYKTVDCCVFQS 344 +K + G+ I + +G+ + + + + + Sbjct: 356 A-----AVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCN-LAWSK 409 Query: 345 NFQELYS--GSRDCNILAWVPSLYEPVPD 371 + EL S G IL W V Sbjct: 410 HANELVSTHGYSQNQILVWKYPSLTQVAK 438 Score = 91.1 bits (224), Expect = 6e-19, Method: Composition-based stats. Identities = 44/252 (17%), Positives = 88/252 (34%), Gaps = 36/252 (14%) Query: 26 RVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCK 85 ++ K + H + L + + SG D +I+ D+ QS + Sbjct: 254 QIWDAAAGKKLSMLEGHTARVGALAWNAEQ---LSSGSRDRMILQRDIRTPPLQSERRLQ 310 Query: 86 AVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVY 145 HR V ++W + S D L VW+ ++L + E Sbjct: 311 G-----------HRQEVCGLKWSTDHQ-LLASGGNDNKLLVWNHSSLSPVQQYT-EHLAA 357 Query: 146 SHHMSPVSTKHCLVAV--GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILA 203 ++ +H L+A GT ++ + +G + Q + ++WS + +++ Sbjct: 358 VKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQ-VCNLAWSKHANELVS 416 Query: 204 TASAD-SRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLT 262 T +++ +W S + T H+ +V L + DG ++T Sbjct: 417 THGYSQNQILVWK----------------YPSLTQVAKLTGHSYRVLYLAMSPDGEAIVT 460 Query: 263 VGTDNRMRLWNS 274 D +R WN Sbjct: 461 GAGDETLRFWNV 472 Score = 59.9 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 22/131 (16%), Positives = 45/131 (34%), Gaps = 9/131 (6%) Query: 246 GKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSS 305 V + ++ G + +++W+++ G+ + G L + Sbjct: 230 DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTAR--VGALAWNAE----- 282 Query: 306 EFVFVPYGSTIAVYTVYSG--EQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVP 363 + I + + + L+GH + V + ++ Q L SG D +L W Sbjct: 283 QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNH 342 Query: 364 SLYEPVPDDDE 374 S PV E Sbjct: 343 SSLSPVQQYTE 353 Score = 54.9 bits (130), Expect = 5e-08, Method: Composition-based stats. Identities = 33/201 (16%), Positives = 61/201 (30%), Gaps = 47/201 (23%) Query: 8 RQTGLEDPLRLRRAE-STRRVLGLELNKDRDV-----------------------ERIHG 43 R RR + + V GL+ + D + H Sbjct: 296 RDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHL 355 Query: 44 GGINTLDIEPVEGRYMLSGG--SDGVIVLYD-LENSSRQSYYTCKAVCSIGRDHPDVHRY 100 + + P + + SGG +D I ++ L Q T VC++ Sbjct: 356 AAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLA--------- 406 Query: 101 SVETVQWYPHDTGMFTSSSFDKT-LKVWDTNTL-QTADVFNFEETVYSHHMSPVSTKHCL 158 W H + ++ + + + VW +L Q A + V MSP Sbjct: 407 ------WSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEA--- 457 Query: 159 VAVGTRGPKVQLCDLKSGSCS 179 + G ++ ++ S + S Sbjct: 458 IVTGAGDETLRFWNVFSKTRS 478 Score = 30.3 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 7/40 (17%), Positives = 20/40 (50%), Gaps = 1/40 (2%) Query: 41 IHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQS 80 H + L + P +G +++G D + +++ + +R + Sbjct: 441 GHSYRVLYLAMSP-DGEAIVTGAGDETLRFWNVFSKTRST 479 >6GMH-W nrPDB Length = 305 Score = 134 bits (336), Expect = 9e-32, Method: Composition-based stats. Identities = 54/326 (16%), Positives = 114/326 (34%), Gaps = 41/326 (12%) Query: 39 ERIHGGGINTLDI---EPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP 95 E+ H I ++ + +++G D ++ ++ + ++ + Sbjct: 12 EQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVD 71 Query: 96 DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVST 154 H + SSS D +++WD + + ++ SP S Sbjct: 72 ISHTLPIA------------ASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQ 119 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLW 214 +A GT KV + ++SG + L + IL++++SP Y LA+ + D + ++ Sbjct: 120 ---YLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKY-LASGAIDGIINIF 175 Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 D+ L TL+ H + L F+ D L+T D +++++ Sbjct: 176 DI-ATGKLLHTLE---------------GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDV 219 Query: 275 SNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHY 334 + N + + C + FV ++ V+ V + + H Sbjct: 220 QH-----ANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQ 274 Query: 335 KTVDCCVFQSNFQELYSGSRDCNILA 360 V + N ++ S D I Sbjct: 275 DQVWGVKYNGNGSKIVSVGDDQEIHI 300 Score = 62.2 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 34/159 (21%), Positives = 62/159 (38%), Gaps = 19/159 (11%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 L + + + K H I +L P + + +++ DG I +YD+++ Sbjct: 163 LASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP-DSQLLVTASDDGYIKIYDVQH 221 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 ++ H V V + P DT F SSS DK++KVWD T Sbjct: 222 ANLAGTL-------------SGHASWVLNVAFCPDDT-HFVSSSSDKSVKVWDVGTRTCV 267 Query: 136 DV-FNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDL 173 F+ ++ V+ + +V+VG ++ + D Sbjct: 268 HTFFDHQDQVWGVKYN--GNGSKIVSVG-DDQEIHIYDC 303 Score = 58.0 bits (138), Expect = 6e-09, Method: Composition-based stats. Identities = 15/145 (10%), Positives = 47/145 (32%), Gaps = 7/145 (4%) Query: 233 KSQAVESANTAHNGKVNGLCFTSD----GLHLLTVGTDNRMRLWNSSNGENTLVNYGKVC 288 + + AH+ + + + ++ ++T D+ +++W + ++ Sbjct: 4 QYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVW---KWRDERLDLQWSL 60 Query: 289 NNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQE 348 + G+ + I ++ + +G+QI + F + Q Sbjct: 61 EGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQY 120 Query: 349 LYSGSRDCNILAWVPSLYEPVPDDD 373 L +G+ + + + D Sbjct: 121 LATGTHVGKVNIFGVESGKKEYSLD 145 >6ELZ-p nrPDB Length = 460 Score = 130 bits (327), Expect = 8e-31, Method: Composition-based stats. Identities = 62/284 (21%), Positives = 114/284 (40%), Gaps = 46/284 (16%) Query: 29 GLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYD---------------- 72 +E K + H + ++D+ + +LS D I + Sbjct: 194 NIEDGKTLAILEGHKAPVVSIDVS--DNSRILSASYDNSIGFWSTIYKEMTVVDPLEDIN 251 Query: 73 -----LENSSRQSYYTCKAVCSIGRDHP----DVHRYSVETVQWYPHDTGMFTSSSFDKT 123 + ++R+ +I R P + H VE V + D + S S D T Sbjct: 252 NPNNKISTAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHT 311 Query: 124 LKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQ 183 +K WD T + D T YS + L+A G+ + L D + G+ S + Q Sbjct: 312 IKTWDLVTARCIDT---RTTSYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQ 368 Query: 184 ----GHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVES 239 GH+ + ++ P +YIL + S D VK+WDVR S + T+ + + +S Sbjct: 369 QQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTS-PMYTITRED-------KS 420 Query: 240 ANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVN 283 N KV + + ++ + +++ G D ++++ + G+N N Sbjct: 421 VQKGVNDKVFAVKW-AEKVGIISAGQDKKIQI---NKGDNIFKN 460 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 56/379 (14%), Positives = 118/379 (31%), Gaps = 77/379 (20%) Query: 43 GGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSV 102 +++LD+ ++++SG DG++ +DL + ++ Y H + Sbjct: 103 EDWVSSLDV-GDGSKHIISGSYDGIVRTWDLSGNVQKQY--------------SGHSGPI 147 Query: 103 ETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVG 162 V++ S+ D+TL++W T + Sbjct: 148 RAVKY--ISNTRLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEV------------ 193 Query: 163 TRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLW-------- 214 +++ G IL+GH+ ++++ S + +AS D+ + W Sbjct: 194 ---------NIEDGKTLAILEGHKAPVVSIDVSDNSR--ILSASYDNSIGFWSTIYKEMT 242 Query: 215 ------DVRRASGCLITLDQHNGK--------KSQAVESANTAHNGKVNGLCF-TSDGLH 259 D+ + + T + K + +A S +H V + F ++D Sbjct: 243 VVDPLEDINNPNNKISTAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTV 302 Query: 260 LLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVY 319 +V D+ ++ W+ L + I ++ Sbjct: 303 GYSVSQDHTIKTWDLVTARCIDTRTTSY------SLLSIAQLSTLNLLACGSSARHITLH 356 Query: 320 T----VYSGEQITMLKGHYKTVDCCVFQSNFQEL-YSGSRDCNILAWVPSLYEP---VPD 371 S L GH V + + SGS D + W P + Sbjct: 357 DPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITR 416 Query: 372 DDETTTKSQLNPAFEDAWS 390 +D++ K + F W+ Sbjct: 417 EDKSVQKGVNDKVFAVKWA 435 Score = 104 bits (258), Expect = 9e-23, Method: Composition-based stats. Identities = 46/342 (13%), Positives = 100/342 (29%), Gaps = 53/342 (15%) Query: 19 RRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSR 78 + R L N + H G I + + ++S G+D + L+ +N Sbjct: 121 GSYDGIVRTWDLSGNVQKQ-YSGHSGPIRAVKY--ISNTRLVSAGNDRTLRLWKTKNDDL 177 Query: 79 QSYYTCKAVCSIGRDHP----------DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWD 128 + +A + + H+ V V D S+S+D ++ W Sbjct: 178 KLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPV--VSIDVSDNSRILSASYDNSIGFWS 235 Query: 129 TNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQE 188 T + V E+ ++ + + + + + + +L+ H Sbjct: 236 TIYKEMTVVDPLEDINNPNNKISTAARKRRKLT-MKDGTI-----RRRAPLSLLESHTAP 289 Query: 189 ILAVSWSPRYDYILATASADSRVKLWDVRRAS---------------------------- 220 + V + + + + S D +K WD+ A Sbjct: 290 VEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYSLLSIAQLSTLNLLACGSS 349 Query: 221 -GCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLL-TVGTDNRMRLWNSSNGE 278 + D G S+ + H V+ L + ++L + D +++W+ + Sbjct: 350 ARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTS 409 Query: 279 N--TLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAV 318 T+ K F V + I + Sbjct: 410 PMYTITREDKSVQKGVNDKVFAVKWAEKVGIISAGQDKKIQI 451 >5WBU-D nrPDB Length = 328 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 61/337 (18%), Positives = 111/337 (32%), Gaps = 33/337 (9%) Query: 14 DP--LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLY 71 DP L + T R + +N L++ P R M++ I +Y Sbjct: 13 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP--DRSMIAAAGYQHIRMY 70 Query: 72 DLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN- 130 DL +++ + V ++ +V ++ D + D T ++WD Sbjct: 71 DLNSNNPNPIISYDGV-----------NKNIASVGFH-EDGRWMYTGGEDCTARIWDLRS 118 Query: 131 -TLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEI 189 LQ +F + + P + + VG + + + DLK+ ++ I Sbjct: 119 RNLQCQRIFQVNAPINCVCLHPNQAE---LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSI 175 Query: 190 LAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVN 249 + P Y+ A S + +W++ T + ++ AH Sbjct: 176 TSAHIDPDASYMAAVNSTGN-CYVWNL--------TGGIGDEVTQLIPKTKIPAHTRYAL 226 Query: 250 GLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSS---E 306 F+ D L T D ++W +SN K N + + C S Sbjct: 227 QCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQY 286 Query: 307 FVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQ 343 V + ++ V +GE GH K V C F Sbjct: 287 IVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 323 Score = 110 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 41/327 (12%), Positives = 97/327 (29%), Gaps = 46/327 (14%) Query: 54 VEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG 113 + + + G D + + + +C+ H D V ++ P D Sbjct: 12 SDPVILATAGYDHTVRFWQAHSG----------ICTRTVQHQD---SQVNALEVTP-DRS 57 Query: 114 MFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDL 173 M ++ + + ++++D N+ + +++ + + G ++ DL Sbjct: 58 MIAAAGY-QHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL 116 Query: 174 KSG--SCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNG 231 +S C I Q + I V P ++ + +WD++ + + Sbjct: 117 RSRNLQCQRIFQVN-APINCVCLHPNQAELIV-GDQSGAIHIWDLKTDHNEQLIPEPEV- 173 Query: 232 KKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNS 291 + D ++ V + +WN + G V Sbjct: 174 ---------------SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKI 218 Query: 292 KKGLKFTVSC---GCSSEFVFVPYGSTIAVYTVYSGEQITML--------KGHYKTVDCC 340 ++ + C S+ T ++ + +T L + + C Sbjct: 219 PAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGC 278 Query: 341 VFQSNFQELYSGSRDCNILAWVPSLYE 367 F + Q + + S D W E Sbjct: 279 AFSGDSQYIVTASSDNLARLWCVETGE 305 Score = 38.0 bits (86), Expect = 0.007, Method: Composition-based stats. Identities = 12/89 (13%), Positives = 30/89 (33%), Gaps = 9/89 (10%) Query: 16 LRLRRAESTRRVL---GLELNKDRDVERIHGG-----GINTLDIEPVEGRYMLSGGSDGV 67 L A+ T ++ L + ++ + G + + +Y+++ SD + Sbjct: 237 LATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG-DSQYIVTASSDNL 295 Query: 68 IVLYDLENSSRQSYYTCKAVCSIGRDHPD 96 L+ +E + Y + D Sbjct: 296 ARLWCVETGEIKREYGGHQKAVVCLAFND 324 >5CXC-A nrPDB Length = 510 Score = 130 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 55/300 (18%), Positives = 110/300 (36%), Gaps = 46/300 (15%) Query: 14 DPLRLRRAESTRRVLGL--------ELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSD 65 D L + T RV EL ++ H G ++ LD++ +++L+ +D Sbjct: 204 DRLASAGMDRTVRVWKYTESDHFTGELKPTLELY-GHTGSVDWLDVDGHS-KHILTASAD 261 Query: 66 GVIVLYDLENSSRQSYYTCK-------------AVCSIGRDHP----DVHRYSVETVQWY 108 G I + +S + S + P +H + Sbjct: 262 GAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFD 321 Query: 109 PHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHH-MSPVSTKHCLVAVGTRGPK 167 P D + S+S D T++ D T Q + S ++ T L+A GT Sbjct: 322 PRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARH 381 Query: 168 VQLCDLKSGSC---SHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRAS---- 220 + + D ++ S L+GH +++++S SP +Y L + S D ++WD+R Sbjct: 382 ITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATK 441 Query: 221 ---------GCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL 271 + +++ + + KV + + D L + + G D ++++ Sbjct: 442 EEGSLGGVSEPVYVIERESWASKGKKKRPVAGDGCKVFSVVW--DKLGIFSGGEDKKVQV 499 Score = 91.5 bits (225), Expect = 5e-19, Method: Composition-based stats. Identities = 49/293 (16%), Positives = 90/293 (30%), Gaps = 36/293 (12%) Query: 111 DTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCL----VAVGTRGP 166 S+S+D L++W+ + A + H + + L +A Sbjct: 157 GQERVLSASYDGLLRIWNASGSVIA---TSPSGSHGGHTASIKAAKFLTSDRLASAGMDR 213 Query: 167 KVQLCDLKSG-------SCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRA 219 V++ + L GH + + +IL TASAD + W +A Sbjct: 214 TVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHIL-TASADGAIGFWSASKA 272 Query: 220 SGCL----ITLDQHNGKKSQAVESANTA----------HNGKVNGLCFTSDGLHLL-TVG 264 S + H K+ +A S +TA H F + + Sbjct: 273 SAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSAS 332 Query: 265 TDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSG 324 D+ +R + + G+ +V+ + + T + S I + + Sbjct: 333 QDHTVRTLDLTTGQ--VVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRAS 390 Query: 325 E---QITMLKGHYKTVDCCVFQSNFQE-LYSGSRDCNILAWVPSLYEPVPDDD 373 + L+GH V + L SGS D W P ++ Sbjct: 391 SATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEE 443 Score = 80.7 bits (197), Expect = 9e-16, Method: Composition-based stats. Identities = 54/414 (13%), Positives = 106/414 (25%), Gaps = 118/414 (28%) Query: 34 KDRDVERIHGGGINTLDI---EPVEGRY----------------MLSGGSDGVIVLYDLE 74 + H ++ +D+ GR+ +LS DG++ +++ Sbjct: 117 PVYEASFEHDDWVSAVDVLSATSPAGRWSSAANSSAAVQPGQERVLSASYDGLLRIWNAS 176 Query: 75 NSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN---- 130 S + + H S++ ++ D S+ D+T++VW Sbjct: 177 GS---------VIATSPSGSHGGHTASIKAAKFLTSDR--LASAGMDRTVRVWKYTESDH 225 Query: 131 -TLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSC----SHILQG- 184 T + S V + + + S + +L G Sbjct: 226 FTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASAPEPDASLLPGA 285 Query: 185 -------------------------HRQEILAVSWSPRYDYILATASADSRVKLWDVRRA 219 H A + PR + +AS D V+ D+ Sbjct: 286 HVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTG 345 Query: 220 --------------------------------SGCLITLDQHNGKKSQAVESANTAHNGK 247 S IT+ + H K Sbjct: 346 QVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANK 405 Query: 248 VNGLCFTSDGLH-LLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSE 306 V L + + + L++ D R+W+ + G S G+ V Sbjct: 406 VVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEG-----SLGGVSEPVYVIERES 460 Query: 307 FVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA 360 + G++ + G V V+ ++SG D + Sbjct: 461 WAS-------------KGKKKRPVAGDGCKVFSVVWDKLG--IFSGGEDKKVQV 499 Score = 54.9 bits (130), Expect = 6e-08, Method: Composition-based stats. Identities = 23/117 (19%), Positives = 40/117 (34%), Gaps = 9/117 (7%) Query: 255 SDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGS 314 +L+ D +R+WN+S G + +K S Sbjct: 156 PGQERVLSASYDGLLRIWNAS-GSVIATSPSGSHGGHTASIKAAKFL-TSDRLASAGMDR 213 Query: 315 TIAVY-----TVYSGEQITMLK--GHYKTVDCCVFQSNFQELYSGSRDCNILAWVPS 364 T+ V+ ++GE L+ GH +VD + + + + S D I W S Sbjct: 214 TVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSAS 270 >2HES-X nrPDB Length = 330 Score = 129 bits (323), Expect = 2e-30, Method: Composition-based stats. Identities = 67/345 (19%), Positives = 121/345 (35%), Gaps = 48/345 (13%) Query: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 +++ I + D + +G +D I L ++ H+ Sbjct: 11 KLYKEKIWSFDFSQG---ILATGSTDRKIKLVSVKYDDFTLIDVLDETA---------HK 58 Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTN-----TLQTADVFNFEETVYSHHMSPVST 154 ++ +V W PH T + + SFD T+ +W T + + E S Sbjct: 59 KAIRSVAWRPH-TSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSN 117 Query: 155 KHCLVAVGTRGPKVQLCDLKSG----SCSHILQGHRQEILAVSWSPRYDYILATASADSR 210 +A +R V + + C +LQ H Q++ V W P + +LA++S D Sbjct: 118 DGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHP-SEALLASSSYDDT 176 Query: 211 VKLW-DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRM 269 V++W D C+ L+ H G V S++ V LC + D+ + Sbjct: 177 VRIWKDYDDDWECVAVLNGHEG----TVWSSDFDKTEGVFRLC---------SGSDDSTV 223 Query: 270 RLWNSSNGENTLVNYGKVCN----NSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGE 325 R+W G++ VC + K + V+ G + V +AVY GE Sbjct: 224 RVWKYM-GDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNGLIASVGADGVLAVYEEVDGE 282 Query: 326 Q----ITMLKGHYKTVDCCVFQS-NFQELY-SGSRDCNILAWVPS 364 L ++ + N + + +G D + W Sbjct: 283 WKVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGIVNFWSLE 327 Score = 91.1 bits (224), Expect = 8e-19, Method: Composition-based stats. Identities = 50/279 (17%), Positives = 93/279 (33%), Gaps = 41/279 (14%) Query: 16 LRLRRAESTRRVLGLELNKDRDVE-------RIHGGGINTLDIEPVEGRYMLSGGSDGVI 68 L +ST + E + DR E H + + +G Y+ + D + Sbjct: 73 LAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWS-NDGYYLATCSRDKSV 131 Query: 69 VLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVW- 127 ++ E Y C +V H V+ V W+P + SSS+D T+++W Sbjct: 132 WIW--ETDESGEEYECISVLQ-------EHSQDVKHVIWHP-SEALLASSSYDDTVRIWK 181 Query: 128 DTNTL-QTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLC--------DLKSGSC 178 D + + V N E + + G+ V++ D + C Sbjct: 182 DYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVC 241 Query: 179 SHILQG-HRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAV 237 IL H++++ V+W ++A+ AD + +++ + + Sbjct: 242 EAILPDVHKRQVYNVAWGFNG--LIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEIN 299 Query: 238 ESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN 276 NGK L T G D + W+ Sbjct: 300 VVKWLELNGK----------TILATGGDDGIVNFWSLEK 328 Score = 80.3 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 38/219 (17%), Positives = 73/219 (33%), Gaps = 28/219 (12%) Query: 179 SHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVE 238 L+ ++++I + +S ILAT S D ++KL V+ LI + Sbjct: 7 IKSLKLYKEKIWSFDFS---QGILATGSTDRKIKLVSVKYDDFTLIDV------------ 51 Query: 239 SANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVC--NNSKKGLK 296 TAH + + + L D+ + +W + + + +K Sbjct: 52 LDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVK 111 Query: 297 FTVSCGCSSEFVFVPYGSTIAVYTVYSG----EQITMLKGHYKTVDCCVFQSNFQELYSG 352 ++ ++ E I++L+ H + V ++ + L S Sbjct: 112 GVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASS 171 Query: 353 SRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSS 391 S D + W DD+ + LN WSS Sbjct: 172 SYDDTVRIWK-------DYDDDWECVAVLNGHEGTVWSS 203 >5K1B-B nrPDB Length = 677 Score = 129 bits (323), Expect = 2e-30, Method: Composition-based stats. Identities = 44/242 (18%), Positives = 83/242 (34%), Gaps = 27/242 (11%) Query: 159 VAVGTRGPKVQLCDLKSGS---CSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 + R +++ + ++ H + + L +AS+D+ VK+W+ Sbjct: 45 LFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLC-CNGKTLISASSDTTVKVWN 103 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 + C+ TL H V L + D + + G D ++ LW+ + Sbjct: 104 AHK-GFCMSTLRT---------------HKDYVKALAYAKDKELVASAGLDRQIFLWDVN 147 Query: 276 NGENTLVNYGKVCNNSKKGLKFTVSC----GCSSEFVFVPYGSTIAVYTVYSGEQITMLK 331 + V +S G K ++ + V + V+ + ++ LK Sbjct: 148 TLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLK 207 Query: 332 GHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPD---DDETTTKSQLNPAFEDA 388 GH V + + + SGS D I W + DE Q+N AF Sbjct: 208 GHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHV 267 Query: 389 WS 390 +S Sbjct: 268 YS 269 Score = 117 bits (293), Expect = 8e-27, Method: Composition-based stats. Identities = 47/300 (15%), Positives = 103/300 (34%), Gaps = 45/300 (15%) Query: 36 RDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP 95 +VE+ + G+N L ++P R + + G D +I ++ + + Y Sbjct: 23 DEVEKYNRNGVNALQLDPALNR-LFTAGRDSIIRIWSVNQHKQDPYIAS----------M 71 Query: 96 DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTK 155 + H V + + S+S D T+KVW+ + + + Sbjct: 72 EHHTDWVNDIVLC-CNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKD--YVKALAYAKD 128 Query: 156 HCLVAVGTRGPKVQLCDLKSGSCS---------HILQGHRQEILAVSWSPRYDYILATAS 206 LVA ++ L D+ + + L G++ I +++ + + I+ + S Sbjct: 129 KELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMN-QLGTIIVSGS 187 Query: 207 ADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTD 266 + +++WD R + + H V L DG L+ +D Sbjct: 188 TEKVLRVWDPRTCAKLMK----------------LKGHTDNVKALLLNRDGTQCLSGSSD 231 Query: 267 NRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQ 326 +RLW+ G+ + +V + L+ + + I + + + Sbjct: 232 GTIRLWSL--GQQRCIATYRVHDEGVWALQVNDAF---THVYSGGRDRKIYCTDLRNPDI 286 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 63/418 (15%), Positives = 139/418 (33%), Gaps = 75/418 (17%) Query: 14 DPLRLRRAESTRRVLGL---ELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVL 70 + L +S R+ + + + H +N + + G+ ++S SD + + Sbjct: 43 NRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLC-CNGKTLISASSDTTVKV 101 Query: 71 YDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN 130 ++ C + H+ V+ + Y D + S+ D+ + +WD N Sbjct: 102 WNAHKG------FCMSTLRT-------HKDYVKALA-YAKDKELVASAGLDRQIFLWDVN 147 Query: 131 TLQTADVFNFEETVYSHHMSPVS-------TKHCLVAVGTRGPKVQLCDLKSGSCSHILQ 183 TL N T S + S ++ G+ +++ D ++ + L+ Sbjct: 148 TLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLK 207 Query: 184 GHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTA 243 GH + A+ + L + S+D ++LW + + C+ T Sbjct: 208 GHTDNVKALLLNRDGTQCL-SGSSDGTIRLWSLGQQR-CIAT---------------YRV 250 Query: 244 HNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTV--SC 301 H+ V L H+ + G D ++ + N + ++ +C LK + S Sbjct: 251 HDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVL----ICEEKAPVLKMELDRSA 306 Query: 302 GCSSEFVFVPYGSTIAVYTVY----------------------SGEQITMLKGHYKTVDC 339 ST+ +T+ + ++KG + C Sbjct: 307 DPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQC 366 Query: 340 CVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDA----WSSSD 393 + + + + + + N+ W V D + + ++ F+ W S D Sbjct: 367 HILN-DKRHILTKDTNNNVAYWDVLKACKVEDLGKVDFEDEIKKRFKMVYVPNWFSVD 423 Score = 76.5 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 27/146 (18%), Positives = 53/146 (36%), Gaps = 2/146 (1%) Query: 245 NGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCS 304 VN L L T G D+ +R+W+ + + Y + + V C Sbjct: 30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQ--DPYIASMEHHTDWVNDIVLCCNG 87 Query: 305 SEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPS 364 + +T+ V+ + G ++ L+ H V + + + + S D I W + Sbjct: 88 KTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVN 147 Query: 365 LYEPVPDDDETTTKSQLNPAFEDAWS 390 + + T T S L+ + +S Sbjct: 148 TLTALTASNNTVTTSSLSGNKDSIYS 173 >5WYK-BB nrPDB Length = 943 Score = 128 bits (321), Expect = 5e-30, Method: Composition-based stats. Identities = 58/367 (15%), Positives = 118/367 (32%), Gaps = 60/367 (16%) Query: 46 INTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETV 105 + ++DI + + + + + G + +++++ + C T Sbjct: 394 VRSIDIS-DDNKLLATASN-GSLKIWNIKTHKCIRTFEC---------------GYALTC 436 Query: 106 QWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRG 165 ++ P + + + L+++D + D + S LV G+ Sbjct: 437 KFLP-GGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLV-TGSAD 494 Query: 166 PKVQLCDLK---------SGSCSHILQGH-------RQEILAVSWSPRYDYILATASADS 209 V+ D K +L+ H +IL V SP Y+ + D+ Sbjct: 495 KTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISL-LDN 553 Query: 210 RVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRM 269 VK++ S + H V + + D ++T D + Sbjct: 554 TVKVF----------------FLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNI 597 Query: 270 RLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITM 329 ++W G+ + +S +KF S F + + + E I Sbjct: 598 KIWGLDFGDCHKSLF--AHQDSIMNVKF---LPQSHNFFSCSKDAVVKYWDGEKFECIQK 652 Query: 330 LKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAW 389 L H V ++ + S S D +I W + V ++E + + ED Sbjct: 653 LYAHQSEVWALAVATDGGFVVSSSHDHSIRIWE-ETEDQVFLEEEKEKELEEQY--EDTL 709 Query: 390 SSSDEEG 396 +S EEG Sbjct: 710 LTSLEEG 716 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 69/441 (15%), Positives = 141/441 (31%), Gaps = 96/441 (21%) Query: 13 EDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLY- 71 ED L + ++ L+ ++ + H G L + + +++ G+D + ++ Sbjct: 174 EDWLISTSKDGMIKLWDLKTHQCIETHIAHTGECWGLAV---KDDLLITTGTDSQVKIWK 230 Query: 72 -DLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN 130 D+EN T + + + T F + DKT++ + Sbjct: 231 LDIENDKMGGKLTEMGIFEKQSKQRGLKIEFITN---SSDKTSFFYIQNADKTIETFRIR 287 Query: 131 TLQ----------------------------------TADVFNFEETVY---SHHMSPVS 153 + F ++Y S + VS Sbjct: 288 KEEEIARGLKKREKRLKEKGLTEEEIAKSIKESYSSFILHPFQTIRSLYKIKSASWTTVS 347 Query: 154 TKHCLVAVGTRGPKVQLC-------DLKSGSCSHI----LQGHRQEILAVSWSPRYDYIL 202 + + + T ++ D S + LQG R ++ ++ S + +L Sbjct: 348 SSKLELVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRTDVRSIDIS-DDNKLL 406 Query: 203 ATASADSRVKLWDVRRASGCLIT--------------------------LDQHNGKKSQA 236 ATAS +K+W+++ C+ T L + S Sbjct: 407 ATASN-GSLKIWNIKT-HKCIRTFECGYALTCKFLPGGLLVILGTRNGELQLFDLASSSL 464 Query: 237 VESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNG-------ENTLVNYGKVCN 289 +++ AH+ + L TSDG L+T D ++ W+ +N + K+ + Sbjct: 465 LDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHH 524 Query: 290 NSKKGLKFTVSC----GCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSN 345 ++ L + C +T+ V+ + S + L GH V + Sbjct: 525 DTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFD 584 Query: 346 FQELYSGSRDCNILAWVPSLY 366 + + + S D NI W Sbjct: 585 SKMIITSSADKNIKIWGLDFG 605 Score = 101 bits (251), Expect = 6e-22, Method: Composition-based stats. Identities = 54/282 (19%), Positives = 107/282 (37%), Gaps = 34/282 (12%) Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMF 115 G+ + S D + ++D++ + D ++ + DT + Sbjct: 39 GQLITSALED--VNIWDIKTGDL-VSKLSDGLPPGASDARGAKPAECTYLEAH-KDTDLL 94 Query: 116 TSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKS 175 D +KVWD + FN + + + + G++ + + DL Sbjct: 95 AVGYADGVIKVWDLMSKTVLLNFNGHK--AAITLLQFDGTGTRLISGSKDSNIIVWDLVG 152 Query: 176 GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQ 235 + L+ H+ I W D++++T S D +KLWD++ C+ T Sbjct: 153 EVGLYKLRSHKDSITGF-WCQGEDWLIST-SKDGMIKLWDLKT-HQCIET---------- 199 Query: 236 AVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLW--NSSNGE--NTLVNYGKVCNNS 291 + AH G+ GL D L+T GTD+++++W + N + L G S Sbjct: 200 -----HIAHTGECWGLAVKDD--LLITTGTDSQVKIWKLDIENDKMGGKLTEMGIFEKQS 252 Query: 292 KKG---LKFTVSCGCSSEFVFVP-YGSTIAVYTVYSGEQITM 329 K+ ++F + + F ++ TI + + E+I Sbjct: 253 KQRGLKIEFITNSSDKTSFFYIQNADKTIETFRIRKEEEIAR 294 Score = 99.2 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 57/433 (13%), Positives = 124/433 (28%), Gaps = 101/433 (23%) Query: 14 DPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDL 73 D L + A+ +V L H I L + G ++SG D I+++DL Sbjct: 92 DLLAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGT-GTRLISGSKDSNIIVWDL 150 Query: 74 ENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ 133 V +G H+ S+ ++ S+S D +K+WD T Q Sbjct: 151 -------------VGEVGLYKLRSHKDSITG--FWCQGEDWLISTSKDGMIKLWDLKTHQ 195 Query: 134 TADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLK--------SGSCSHILQGH 185 + L+ GT +V++ L + I + Sbjct: 196 CIETHIAHT---GECWGLAVKDDLLITTGT-DSQVKIWKLDIENDKMGGKLTEMGIFEKQ 251 Query: 186 RQ----EILAVSWSPRYDYILATASADSRVKLWDVRRASG-------------CLITLDQ 228 + +I ++ S +AD ++ + +R+ ++ Sbjct: 252 SKQRGLKIEFITNSSDKTSFFYIQNADKTIETFRIRKEEEIARGLKKREKRLKEKGLTEE 311 Query: 229 HNGKKSQAVESANTAHN-------GKVNGLCF---TSDGLHLLTVGTDNRMRLWN--SSN 276 K + S+ H K+ + +S L L+ + N + ++ Sbjct: 312 EIAKSIKESYSSFILHPFQTIRSLYKIKSASWTTVSSSKLELVLTTSSNTIEYYSIPYEK 371 Query: 277 GENTLVNYGKVCNNSKKGLKF---TVSCGCSSEFVFVPYGSTIAVYTVYSGEQITML--- 330 + T K +G + ++ ++ + ++ ++ + + + I Sbjct: 372 RDPTSPAPLKTHTIELQGQRTDVRSIDISDDNKLLATASNGSLKIWNIKTHKCIRTFECG 431 Query: 331 --------------------------------------KGHYKTVDCCVFQSNFQELYSG 352 H + S+ + L +G Sbjct: 432 YALTCKFLPGGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTG 491 Query: 353 SRDCNILAWVPSL 365 S D + W + Sbjct: 492 SADKTVKFWDFKV 504 Score = 78.0 bits (190), Expect = 6e-15, Method: Composition-based stats. Identities = 51/362 (14%), Positives = 110/362 (30%), Gaps = 71/362 (19%) Query: 54 VEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG 113 + + G +DGVI ++DL + + + + H+ ++ +Q+ Sbjct: 89 KDTDLLAVGYADGVIKVWDLMSKTVLLNF-------------NGHKAAITLLQFD-GTGT 134 Query: 114 MFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDL 173 S S D + VWD + + + L++ ++ ++L DL Sbjct: 135 RLISGSKDSNIIVWDLVGEVGLYKLRSHKDSITGFW--CQGEDWLIST-SKDGMIKLWDL 191 Query: 174 KSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKK 233 K+ C H E ++ +L T DS+VK+W + + + G Sbjct: 192 KTHQCIETHIAHTGECWGLAVKDD---LLITTGTDSQVKIWKLDIENDKMGGKLTEMGIF 248 Query: 234 SQAVESANTAHNGKVNGLCFTSDGLHLL-TVGTDNRMR---------------------- 270 + + K+ + +SD D + Sbjct: 249 EKQSKQRGL----KIEFITNSSDKTSFFYIQNADKTIETFRIRKEEEIARGLKKREKRLK 304 Query: 271 ---LWNSSNGENTLVNYGKVC---NNSKKGLKFTVSCGCSS------EFVFVPYGSTIAV 318 L ++ +Y + + L S ++ E V +TI Sbjct: 305 EKGLTEEEIAKSIKESYSSFILHPFQTIRSLYKIKSASWTTVSSSKLELVLTTSSNTIEY 364 Query: 319 YTV-------YSGEQITM----LKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYE 367 Y++ S + L+G V + + L + S ++ W ++ Sbjct: 365 YSIPYEKRDPTSPAPLKTHTIELQGQRTDVRSIDISDDNKLLATASN-GSLKIWNIKTHK 423 Query: 368 PV 369 + Sbjct: 424 CI 425 Score = 74.6 bits (181), Expect = 7e-14, Method: Composition-based stats. Identities = 28/171 (16%), Positives = 58/171 (33%), Gaps = 12/171 (7%) Query: 199 DYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGL 258 ++ +A D V +WD++ + + + A A + L D Sbjct: 39 GQLITSALED--VNIWDIKTGDL----VSKLSDGLPPGASDARGAKPAECTYLEAHKDTD 92 Query: 259 HLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAV 318 L D +++W+ + L G + L+F G + + S I V Sbjct: 93 LLAVGYADGVIKVWDLMSKTVLLNFNG--HKAAITLLQFD---GTGTRLISGSKDSNIIV 147 Query: 319 YTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPV 369 + + + L+ H ++ + L S S+D I W ++ + Sbjct: 148 WDLVGEVGLYKLRSHKDSITGF-WCQGEDWLISTSKDGMIKLWDLKTHQCI 197 >6EOJ-D nrPDB Length = 470 Score = 126 bits (316), Expect = 1e-29, Method: Composition-based stats. Identities = 47/277 (16%), Positives = 102/277 (36%), Gaps = 47/277 (16%) Query: 26 RVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCK 85 + + + H + T+ + +M+SG +DG+I ++ + Sbjct: 118 SLWNASSFTFETLMQAHDSAVTTMKYS-HDSDWMISGDADGMIKIW-------------Q 163 Query: 86 AVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVY 145 S+ ++ H S+ + + +D+ F + S D LK+W+ + + V + + Sbjct: 164 PNFSMVKEIDAAHTESIRDMAFSSNDSK-FVTCSDDNILKIWNFSNGKQERVLSGHH--W 220 Query: 146 SHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATA 205 + L+A ++ V+L D +SG+C + + +L + P +L Sbjct: 221 DVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAI 280 Query: 206 SADSRVKLWDVRRASGCL---------ITLDQHNGKKS---------------------Q 235 S D +++D+R + L +TL+ H +S + Sbjct: 281 SKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNE 340 Query: 236 AVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLW 272 + + AH+ + L + G T D +R W Sbjct: 341 PILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 108 bits (270), Expect = 3e-24, Method: Composition-based stats. Identities = 38/203 (18%), Positives = 74/203 (36%), Gaps = 23/203 (11%) Query: 159 VAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRR 218 + V T + L + S + ++Q H + + +S D+++ + AD +K+W Sbjct: 108 LVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMI-SGDADGMIKIW---- 162 Query: 219 ASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 V+ + AH + + F+S+ +T DN +++WN SNG+ Sbjct: 163 ------------QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGK 210 Query: 279 NTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVD 338 V G +K + + ++ SG I+ + TV Sbjct: 211 QERVLSGH-----HWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVL 265 Query: 339 CCVFQS-NFQELYSGSRDCNILA 360 FQ L + S+D + Sbjct: 266 KTRFQPTKGNLLMAISKDKSCRV 288 Score = 97.3 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 40/335 (11%), Positives = 97/335 (28%), Gaps = 79/335 (23%) Query: 99 RYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPV----ST 154 ++ + +QW P + +++ +W+ ++ F FE + +H + S Sbjct: 93 KHVIPAIQWTPEGRRLVV-ATYSGEFSLWNASS------FTFETLMQAHDSAVTTMKYSH 145 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLW 214 + G +++ I H + I +++S T S D+ +K+W Sbjct: 146 DSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSK-FVTCSDDNILKIW 204 Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 + + + H+ V + + + + DN ++LW+ Sbjct: 205 NFSNGKQERV----------------LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDP 248 Query: 275 SNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVY------------ 322 +G + LK + + + + V+ + Sbjct: 249 RSGNCI----SSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDE 304 Query: 323 ----------------------------------SGEQITMLKGHYKTVDCCVFQSNFQE 348 + +T+ H K + + Sbjct: 305 TDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHI 364 Query: 349 LYSGSRDCNILAWVPSLY-EPVPDDDETTTKSQLN 382 + ++D I W + +P DD T ++N Sbjct: 365 FATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKIN 399 Score = 88.8 bits (218), Expect = 3e-18, Method: Composition-based stats. Identities = 40/244 (16%), Positives = 84/244 (34%), Gaps = 23/244 (9%) Query: 13 EDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYD 72 + ++ ++ K V H + + D P G + S D ++ L+D Sbjct: 189 DSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMG-LIASASKDNLVKLWD 247 Query: 73 LENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN-T 131 + + S +++V ++ P + + S DK+ +V+D + Sbjct: 248 PRSGNCISSILKF-------------KHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYS 294 Query: 132 LQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHIL---QGHRQE 188 ++ E + P++ +A ++ DL IL H + Sbjct: 295 MKELMCVRDETDYMTLEWHPINESMFTLAC--YDGSLKHFDLLQNLNEPILTIPYAHDKC 352 Query: 189 ILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKV 248 I ++S++P +I ATA+ D ++ W R D K + N + Sbjct: 353 ITSLSYNP-VGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNK--KINGWFFGINNDI 409 Query: 249 NGLC 252 N + Sbjct: 410 NAVR 413 Score = 88.1 bits (216), Expect = 6e-18, Method: Composition-based stats. Identities = 33/201 (16%), Positives = 73/201 (36%), Gaps = 25/201 (12%) Query: 186 RQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHN 245 + I A+ W+P ++ A+ LW+ S E+ AH+ Sbjct: 93 KHVIPAIQWTPEGRRLVV-ATYSGEFSLWNAS----------------SFTFETLMQAHD 135 Query: 246 GKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSS 305 V + ++ D +++ D +++W + ++ + ++ S Sbjct: 136 SAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHT-----ESIRDMAFSSNDS 190 Query: 306 EFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSL 365 +FV + + ++ +G+Q +L GH+ V C + + S S+D + W P Sbjct: 191 KFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRS 250 Query: 366 Y---EPVPDDDETTTKSQLNP 383 + T K++ P Sbjct: 251 GNCISSILKFKHTVLKTRFQP 271 Score = 51.1 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 23/107 (21%), Positives = 40/107 (37%), Gaps = 5/107 (4%) Query: 289 NNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQE 348 N K + V Y +++ S T+++ H V + + Sbjct: 90 NKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDW 149 Query: 349 LYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDEE 395 + SG D I W P+ + V + D T+S + AF SS+D + Sbjct: 150 MISGDADGMIKIWQPN-FSMVKEIDAAHTESIRDMAF----SSNDSK 191 >5WLC-LJ nrPDB Length = 513 Score = 126 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 57/302 (18%), Positives = 110/302 (36%), Gaps = 38/302 (12%) Query: 70 LYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDT 129 L + + Q Y+ + ++H V S +PHD + +S+ ++++ + Sbjct: 15 LLPQQTTPEQRYWRQYTSAQLVKEHNSVTHISFNP--QHPHDFAVTSSTR----VQIFSS 68 Query: 130 NTLQTADVFN-FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCD-LKSGSCSHILQGHRQ 187 T Q F+ F++ VYS L+ G V + D + + Sbjct: 69 RTRQVIKTFSRFKDVVYSASFRS---DGKLLCAGDATGLVSVYDSYNPRTILLSINASTH 125 Query: 188 EILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGK 247 + + + ILATAS D +LWD+ A + L T Sbjct: 126 PTHVTKFHTQDNKILATASDDRVTRLWDISNAYEPQLEL---------------TGATDY 170 Query: 248 VNGLCFTSDGLHLL-TVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSE 306 V L F HL+ T D +RL+++ + +T + N + ++ ++ + Sbjct: 171 VRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSL----NHDQPVENVIAVSPTQI 226 Query: 307 FVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNF-----QELYSGSRDCNILAW 361 G+ V+ + S +++ K V C + NF L + S D ++ + Sbjct: 227 VSCG--GNNFKVWDLTSNKKLYERGNFNKAVTCLDYVENFDSPMQSALIASSLDGHVKVF 284 Query: 362 VP 363 P Sbjct: 285 DP 286 Score = 79.6 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 51/335 (15%), Positives = 114/335 (34%), Gaps = 39/335 (11%) Query: 26 RVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCK 85 ++ + + + +G+ + +G + G++ +YD N Sbjct: 64 QIFSSRTRQVIKTFSRFKDVVYSASFR-SDGKLLCAGDATGLVSVYDSYNPRTILLSINA 122 Query: 86 AVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVY 145 + H V +++ D + ++S D+ ++WD + + T Y Sbjct: 123 ST----------HPTHVT--KFHTQDNKILATASDDRVTRLWDISNAYEPQLELTGATDY 170 Query: 146 SHHMSPVSTKHCLVAVGTRGPKVQLCDLKS--GSCSHILQGHRQEILAV-SWSPRYDYIL 202 +S + LVA G+ ++L D +S + + L H Q + V + SP + Sbjct: 171 VRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSL-NHDQPVENVIAVSPTQ---I 226 Query: 203 ATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLT 262 + ++ K+WD+ G ++AV + N + L+ Sbjct: 227 VSCGGNNF-KVWDLTSNKKLY-----ERGNFNKAVTCLDYVENFD------SPMQSALIA 274 Query: 263 VGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVY 322 D +++++ +N V +G S L VS + + G + + + Sbjct: 275 SSLDGHVKVFDPL--DNFQVKFGW--KFSGPVLSCAVSPSTAQGNRHLVAGLSSGLLAIR 330 Query: 323 SGEQITMLKGHYKTVDCC---VFQSNFQELYSGSR 354 + ++ +NFQ + GS Sbjct: 331 TKKKEKRSSDKENAPASFNKNAKSNNFQRMMRGSE 365 Score = 39.9 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 23/151 (15%), Positives = 47/151 (31%), Gaps = 11/151 (7%) Query: 222 CLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTL 281 T + + HN V + F H V + R+++++S + Sbjct: 17 PQQTTPEQRYWRQYTSAQLVKEHNS-VTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIK 75 Query: 282 VNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGST-IAVYTVYSGE-QITMLKGHYKTVDC 339 K + ++ S + + + ++VY Y+ + + Sbjct: 76 TFSR------FKDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHV 129 Query: 340 CVFQ-SNFQELYSGSRDCNILAWVPS-LYEP 368 F + + L + S D W S YEP Sbjct: 130 TKFHTQDNKILATASDDRVTRLWDISNAYEP 160 >1NR0-A nrPDB Length = 611 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 66/353 (18%), Positives = 131/353 (37%), Gaps = 33/353 (9%) Query: 13 EDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYD 72 + ++T + K + H ++++ P +G S G DG IVLY+ Sbjct: 160 PFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVLYN 218 Query: 73 LENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTL 132 + ++ + ++ ++ H SV + W P D S+S DKT+K+W+ TL Sbjct: 219 GVDGTKTGVFEDDSLKNVA------HSGSVFGLTWSP-DGTKIASASADKTIKIWNVATL 271 Query: 133 QTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAV 192 + + + + TK LV++ + + + + GS + GH + I A+ Sbjct: 272 KVEKTIPVGTRIEDQQLGIIWTKQALVSI-SANGFINFVNPELGSIDQVRYGHNKAITAL 330 Query: 193 SWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLC 252 S S + +A A+ + WD+ + D H + G+ Sbjct: 331 SSSADGKTLF-SADAEGHINSWDISTGISNRVFPDV---------------HATMITGIK 374 Query: 253 FTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPY 312 TS G L TV D+ +++ + V+ K N ++ + Sbjct: 375 TTSKGD-LFTVSWDDHLKV---VPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAAC 430 Query: 313 GSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSL 365 IA+Y+ G+ + + C ++ Q + G +D + + S Sbjct: 431 YKHIAIYS--HGKLTEVPISYNS--SCVALSNDKQFVAVGGQDSKVHVYKLSG 479 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 53/336 (15%), Positives = 114/336 (33%), Gaps = 34/336 (10%) Query: 35 DRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDH 94 D ++ H P G Y SG G + ++D + Q+ + K + Sbjct: 51 DTEIYTEHSHQTTVAKTSP-SGYYCASGDVHGNVRIWD----TTQTTHILKTTIPVF--- 102 Query: 95 PDVHRYSVETVQWYPHDTGMFTSSSFD---KTLKVWDTNTLQTADVFNFEETVYSHHMSP 151 V+ + W + + ++DT T ++ + S P Sbjct: 103 ----SGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGT-SNGNLTGQARAMNSVDFKP 157 Query: 152 VSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRV 211 ++ + G+ V + + H + + +V ++P + A+ D + Sbjct: 158 --SRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGS-LFASTGGDGTI 214 Query: 212 KLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL 271 L++ +D + N AH+G V GL ++ DG + + D +++ Sbjct: 215 VLYN---------GVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKI 265 Query: 272 WNSSNGE-NTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITML 330 WN + + + G + + G+ +T V + I G + Sbjct: 266 WNVATLKVEKTIPVGTRIEDQQLGIIWTKQA-----LVSISANGFINFVNPELGSIDQVR 320 Query: 331 KGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLY 366 GH K + ++ + L+S + +I +W S Sbjct: 321 YGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 Score = 80.3 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 57/318 (17%), Positives = 100/318 (31%), Gaps = 47/318 (14%) Query: 31 ELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYY-------- 82 EL V H I L +G+ + S ++G I +D+ + Sbjct: 312 ELGSIDQVRYGHNKAITALS-SSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMI 370 Query: 83 TCKAVCSIGRDHP---DVHRYSV----------ETVQWYPHDTGMFTSSSFDKTLKVWDT 129 T S G D H V + V + + S D + V Sbjct: 371 TGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAV--A 428 Query: 130 NTLQTADVFNFEETV-----YSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQ- 183 + +++ + Y+ +S VAVG + KV + L S S + Sbjct: 429 ACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTI 488 Query: 184 GHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTA 243 H EI +V++S +++AT + A ++ T Sbjct: 489 VHPAEITSVAFSNNGAFLVAT--------------DQSRKVIPYSVANNFELAHTNSWTF 534 Query: 244 HNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGC 303 H KV + ++ D + L T DN + +WN + + + S +V Sbjct: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVN---SVIWLN 591 Query: 304 SSEFVFVPYGSTIAVYTV 321 + V S I + V Sbjct: 592 ETTIVSAGQDSNIKFWNV 609 Score = 57.6 bits (137), Expect = 9e-09, Method: Composition-based stats. Identities = 36/233 (15%), Positives = 72/233 (30%), Gaps = 27/233 (11%) Query: 164 RGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCL 223 G V + S + + I H + SP Y A+ V++WD + + L Sbjct: 37 NGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSG-YYCASGDVHGNVRIWDTTQTTHIL 95 Query: 224 ITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTD----NRMRLWNSSNGEN 279 T +G V + + S+ + VG + L+++ Sbjct: 96 KTTIPVF--------------SGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNG 141 Query: 280 TLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDC 339 L + N + F S + +T+A++ + + H K V Sbjct: 142 NLTGQARAMN----SVDFKPSRPF--RIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHS 195 Query: 340 CVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPA--FEDAWS 390 + + S D I+ + ++ + K+ + F WS Sbjct: 196 VRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 Score = 48.4 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 23/147 (15%), Positives = 46/147 (31%), Gaps = 6/147 (4%) Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN 276 + C T S T H+ + + G + + +R+W+++ Sbjct: 31 DKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQ 90 Query: 277 GENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYG--STIAVYTVYSGEQITMLKGHY 334 + L V + +K S V G V+ +G L G Sbjct: 91 TTHILKTTIPVFS---GPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQA 147 Query: 335 KTVDCCVFQSNFQE-LYSGSRDCNILA 360 + ++ F+ + + SGS D + Sbjct: 148 RAMNSVDFKPSRPFRIISGSDDNTVAI 174 >4YCZ-A nrPDB Length = 876 Score = 120 bits (301), Expect = 9e-28, Method: Composition-based stats. Identities = 54/303 (17%), Positives = 108/303 (35%), Gaps = 52/303 (17%) Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQW-YPHDTGM 114 GR + + SD I ++++E +++ T K H +V V W +P + Sbjct: 30 GRRLATCSSDRTIKIFEIEGETQRLTETLKG-----------HDGAVWCVSWAHPKYGNI 78 Query: 115 FTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTK--HCLVAVGTRGPKVQLCD 172 S+ +D + +W +F+F S ++ S CL+A + V + + Sbjct: 79 LASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVSVLE 138 Query: 173 LKSGSCSH-ILQGHRQEILAVSWSP----------------RYDYILATASADSRVKLWD 215 + S H I H + +VSW+P + T +D+ +K+W Sbjct: 139 FRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWA 198 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS---DGLHLLTVGTDNRMRLW 272 A+ + T H V + ++ ++ + D +R+W Sbjct: 199 YDPATN-----------TYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIW 247 Query: 273 NSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYG-STIAVYTVYSG---EQIT 328 +S+ N L KV N + VS S + G + + ++ E + Sbjct: 248 -TSDPANPLQWNCKVLNFDAA--VWRVSWSLSGNVLAASGGDNKVTLWKENLKGEWECVK 304 Query: 329 MLK 331 ++ Sbjct: 305 TIE 307 Score = 120 bits (299), Expect = 1e-27, Method: Composition-based stats. Identities = 61/363 (16%), Positives = 120/363 (33%), Gaps = 55/363 (15%) Query: 16 LRLRRAESTRRVLGLELNKDR--DVERIHGGGINTLDI-EPVEGRYMLSGGSDGVIVLYD 72 L ++ T ++ +E R + + H G + + P G + S G DG ++++ Sbjct: 33 LATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIWR 92 Query: 73 LENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG-MFTSSSFDKTLKVWDTNT 131 N + Q + +H+ SV V W PH+ G + +S D + V + Sbjct: 93 ELNGAWQRIFDFA-----------LHKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRD 141 Query: 132 LQTADVFNFEE--TVYSHHMSPVSTKHCLVA--------------VGTRGPKVQLC--DL 173 V S +P ++ +V+ G +++ D Sbjct: 142 NSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDP 201 Query: 174 KSGSCS---HILQGHRQEILAVSWSPR--YDYILATASADSRVKLWDVRRASGCLITLDQ 228 + + L GH + V+WSP +A+AS D V++W T D Sbjct: 202 ATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIW----------TSDP 251 Query: 229 HNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVC 288 N + + V + ++ G L G DN++ LW N + + Sbjct: 252 ANPLQWNCKVLNF---DAAVWRVSWSLSGNVLAASGGDNKVTLWK-ENLKGEWECVKTIE 307 Query: 289 NNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQE 348 + G + P + + +I +G ++ + N Sbjct: 308 EGGGGSGGGGQAKGPTQPEQASPAKGFVK-WPYQQRPKIDQQEG--PSIPRTNWGPNGLL 364 Query: 349 LYS 351 + + Sbjct: 365 VTT 367 Score = 101 bits (251), Expect = 6e-22, Method: Composition-based stats. Identities = 44/282 (15%), Positives = 89/282 (31%), Gaps = 16/282 (5%) Query: 94 HPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN--TLQTADVFNFEETVYSHHMSP 151 H + + + S D+T+K+++ T + + + Sbjct: 13 ANSGHDDMIHDAVLDYYGR-RLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWA 71 Query: 152 VSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQG--HRQEILAVSWSPRY-DYILATASAD 208 ++A KV + +G+ I H+ + VSWSP +LA AS+D Sbjct: 72 HPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSD 131 Query: 209 SRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGL---HLLTVGT 265 V + + R S H G +V A G + +T G+ Sbjct: 132 GNVSVLEFRDNSWEHSIFHAH-GLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGS 190 Query: 266 DNRMRLWNSSNGENTLVNYGKV---CNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVY 322 DN +++W NT + + + + ++ + S T+ ++T Sbjct: 191 DNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSD 250 Query: 323 SGEQIT---MLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 + + V + + L + D + W Sbjct: 251 PANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLW 292 Score = 95.8 bits (236), Expect = 3e-20, Method: Composition-based stats. Identities = 35/239 (14%), Positives = 74/239 (30%), Gaps = 44/239 (18%) Query: 159 VAVGTRGPKVQLCDLK--SGSCSHILQGHRQEILAVSW-SPRYDYILATASADSRVKLWD 215 +A + +++ +++ + + L+GH + VSW P+Y ILA+A D +V +W Sbjct: 33 LATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIWR 92 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD--GLHLLTVGTDNRMRLWN 273 + I H VN + ++ G L +D + + Sbjct: 93 ELNGAWQRI--------------FDFALHKASVNVVSWSPHEAGCLLACASSDGNVSV-- 136 Query: 274 SSNGENTLVNYG-KVCNNSKKGLKFTVSCGC--------------SSEFVFVPYGSTIAV 318 +N+ + + + + + FV + + + Sbjct: 137 LEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKI 196 Query: 319 YTVYSGEQITMLK-----GHYKTVDCCVFQS---NFQELYSGSRDCNILAWVPSLYEPV 369 + L+ GH V + + S S D + W P+ Sbjct: 197 WAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANPL 255 Score = 83.0 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 31/240 (12%), Positives = 65/240 (27%), Gaps = 36/240 (15%) Query: 173 LKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGK 232 + +G+ GH I LAT S+D +K++++ + L Sbjct: 5 MAAGTQVIANSGHDDMIHDAVLDYYGR-RLATCSSDRTIKIFEIEGETQRLTE------- 56 Query: 233 KSQAVESANTAHNGKVNGLCFT--SDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNN 290 H+G V + + G L + G D ++ +W NG + + Sbjct: 57 -------TLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKA 109 Query: 291 SKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQIT-MLKGHYKTVDCCVFQS----- 344 S + ++ ++V + H V+ + Sbjct: 110 SVNVVSWSPHEA-GCLLACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPG 168 Query: 345 ------------NFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSSS 392 + +G D + W + + + AWS + Sbjct: 169 SIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPT 228 Score = 33.7 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 9/48 (18%), Positives = 17/48 (35%) Query: 320 TVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYE 367 ++ +G Q+ GH + V + L + S D I + Sbjct: 4 SMAAGTQVIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGET 51 >6J6H-n nrPDB Length = 455 Score = 120 bits (301), Expect = 9e-28, Method: Composition-based stats. Identities = 54/323 (16%), Positives = 106/323 (32%), Gaps = 39/323 (12%) Query: 39 ERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVH 98 H G L P G +LSGG+D I ++D + Y C H Sbjct: 158 YPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD-----YECLRDFQ-------GH 205 Query: 99 RYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCL 158 ++ +++ D F SSSFD+++K+WDT T + + T P + + Sbjct: 206 NKPIKALRF-TEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFI 264 Query: 159 VAVGTRGPKVQLCDLKSGSC---SHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 V G K+ D + H ILA+ + P +++ S D V++W Sbjct: 265 V--GLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISS-SEDKTVRIW- 320 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 + + ++ + + L + DNR+ ++ Sbjct: 321 --------------ENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLK 366 Query: 276 -NGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLK-GH 333 + K +++ G+ G S + + + + +K Sbjct: 367 PKYKRHPKKIFKGHSSAGYGISL-AFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPG 425 Query: 334 YKTVDCCVFQSN--FQELYSGSR 354 K + + + + SG+ Sbjct: 426 NKPITQVDWHPQETSKVICSGAA 448 Score = 105 bits (261), Expect = 4e-23, Method: Composition-based stats. Identities = 34/207 (16%), Positives = 65/207 (31%), Gaps = 23/207 (11%) Query: 176 GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQ 235 GH + A+ + P+ +++ + D +K+WD CL Sbjct: 152 KKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLR----------- 200 Query: 236 AVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGL 295 HN + L FT D L+ D +++W++ G+ + + Sbjct: 201 ----DFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESR 256 Query: 296 KFTVSCGCSSEFVFVPYGSTIAVYTVYSGE---QITMLKGHYKTVDCCVFQSNFQELYSG 352 EF+ S I Y E + H ++ + + + S Sbjct: 257 PTNPH-----EFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISS 311 Query: 353 SRDCNILAWVPSLYEPVPDDDETTTKS 379 S D + W + P+ +T S Sbjct: 312 SEDKTVRIWENQINVPIKQISDTAQHS 338 Score = 93.4 bits (230), Expect = 1e-19, Method: Composition-based stats. Identities = 35/251 (13%), Positives = 73/251 (29%), Gaps = 40/251 (15%) Query: 152 VSTKHCLVAVGTRGPKVQLCD-LKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSR 210 + L+ G +++ D C QGH + I A+ ++ L++ S D Sbjct: 171 LPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSS-SFDRS 229 Query: 211 VKLWDVR----RASGCLITLDQHNGKKSQAVESANTA----------------------- 243 VK+WD + L + + Sbjct: 230 VKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTY 289 Query: 244 --HNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSC 301 H + L + DG ++ D +R+W V ++ + ++ + F Sbjct: 290 DHHLSSILALKYFPDGSKFISSSEDKTVRIWE----NQINVPIKQISDTAQHSMPFLNVH 345 Query: 302 GCSSEFVFVPYGSTIAVYTVYSGE---QITMLKGHYKTVD--CCVFQSNFQELYSGSRDC 356 + F + I +++ + KGH F + + + SG Sbjct: 346 PSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKS 405 Query: 357 NILAWVPSLYE 367 + W + Sbjct: 406 RLFTWDWNTSR 416 Score = 63.8 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 26/189 (13%), Positives = 54/189 (28%), Gaps = 18/189 (9%) Query: 31 ELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSI 90 E H I L P +G +S D + +++ Q K + Sbjct: 281 ENQGLVQTYDHHLSSILALKYFP-DGSKFISSSEDKTVRIWE-----NQINVPIKQISDT 334 Query: 91 GRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN---TLQTADVFNFEETVYSH 147 + H V +P F + S D + + +F + Sbjct: 335 AQ-----HSMPFLNV--HPSQ-NYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYG 386 Query: 148 HMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQ-GHRQEILAVSWSPRYDYILATAS 206 S + G ++ D + + ++ + I V W P+ + + Sbjct: 387 ISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSG 446 Query: 207 ADSRVKLWD 215 A ++ + D Sbjct: 447 AAGKIYVCD 455 >5WLC-LU nrPDB Length = 489 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 62/392 (15%), Positives = 122/392 (31%), Gaps = 55/392 (14%) Query: 17 RLRRAESTRRVLGLELNKDR------DVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVL 70 R E T+ + +L + + H G+ + + +G +DGVI Sbjct: 35 FERAREYTKALNATKLERMFAKPFVGQLGYGHRDGVYAIAKNYGSLNKLATGSADGVIKY 94 Query: 71 YDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVW--- 127 +++ + G V + + S S DKT+K+W Sbjct: 95 WNMSTREEFVSFKAHYGLVTGL---CVTQPRFHDKKPDLKSQNFMLSCSDDKTVKLWSIN 151 Query: 128 ------------DTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKS 175 D+ T + + F+ + G + + L D+ Sbjct: 152 VDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQGIDSHRENSTFATGGAK---IHLWDVNR 208 Query: 176 GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQ 235 L I ++ ++ ILA+ +D+ + L+D+R S + Sbjct: 209 LKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIVQ-------- 260 Query: 236 AVESANTAHNGKVNGLCFTS-DGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKG 294 + N +C+ + + +T D+ ++ N L V + Sbjct: 261 ---------TMRTNAICWNPMEAFNFVTANEDHNAYYYDMRN----LSRSLNVFKDHVSA 307 Query: 295 LKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKT---VDCCVFQSNFQELYS 351 + E V Y +I +Y G + H K V + + + + S Sbjct: 308 VMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIY--HTKRMQHVFQVKYSMDSKYIIS 365 Query: 352 GSRDCNILAWVPSLYEPVPDDDETTTKSQLNP 383 GS D N+ W +E + T K++L Sbjct: 366 GSDDGNVRLWRSKAWER-SNVKTTREKNKLEY 396 Score = 91.1 bits (224), Expect = 8e-19, Method: Composition-based stats. Identities = 54/352 (15%), Positives = 103/352 (29%), Gaps = 57/352 (16%) Query: 73 LENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTL 132 L + + + V +G HR V + + S D +K W+ +T Sbjct: 45 LNATKLERMFAKPFVGQLGY----GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTR 100 Query: 133 QTADVFNFEETVY---------SHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQ 183 + F + H P + + V+L + S+ Sbjct: 101 EEFVSFKAHYGLVTGLCVTQPRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNS 160 Query: 184 GHRQEILA-----------VSW----SPRYDYILATASADSRVKLWDVRRASGCLITLDQ 228 + ++ S R + AT A ++ LWDV R Sbjct: 161 SDNDSVTNEEGLIRTFDGESAFQGIDSHRENSTFATGGA--KIHLWDVNRLK-------- 210 Query: 229 HNGKKSQAVESANTAHNGKVNGLCFTSDGL-HLLTVGTDNRMRLWNSSNGENTLVNYGKV 287 + + A N + L F + L + G+DN + L++ T V Sbjct: 211 ------PVSDLSWGADN--ITSLKFNQNETDILASTGSDNSIVLYDLRTNSPT---QKIV 259 Query: 288 CNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYS-GEQITMLKGHYKTVDCCVFQSNF 346 + + + FV Y + + + + K H V F Sbjct: 260 QTMRTNAICWNPMEAFN--FVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTG 317 Query: 347 QELYSGSRDCNILAWVPSLY--EPVPDDDETTTKSQLNPAFEDAW--SSSDE 394 E+ +GS D +I + + + Q+ + + + S SD+ Sbjct: 318 DEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQHVFQVKYSMDSKYIISGSDD 369 Score = 37.6 bits (85), Expect = 0.009, Method: Composition-based stats. Identities = 13/83 (15%), Positives = 32/83 (38%), Gaps = 6/83 (7%) Query: 14 DPLRLRRAESTRRVLGLELNKDRDVERIHGG---GINTLDIEPVEGRYMLSGGSDGVIVL 70 D + + + R+ R++ H + + ++ +Y++SG DG + L Sbjct: 318 DEIVTGSYDKSIRIYKTNHGHSREIY--HTKRMQHVFQVKYS-MDSKYIISGSDDGNVRL 374 Query: 71 YDLENSSRQSYYTCKAVCSIGRD 93 + + R + T + + D Sbjct: 375 WRSKAWERSNVKTTREKNKLEYD 397 >4J0W-A nrPDB Length = 343 Score = 117 bits (293), Expect = 8e-27, Method: Composition-based stats. Identities = 49/328 (14%), Positives = 102/328 (31%), Gaps = 34/328 (10%) Query: 34 KDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRD 93 D V R H I L + P + + S D I+ + +E+ + + G+ Sbjct: 5 ADIRVLRGHQLSITCLVVTP-DDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGK- 62 Query: 94 HPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVS 153 P H V + D S K + +W+ + Q F S Sbjct: 63 -PPGHSSHVLCMAISS-DGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSG--LAFR 118 Query: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKL 213 + + V++ ++ S L GH+ + A+ + + + D V++ Sbjct: 119 RGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALD-ALSRECCVTAGGRDGTVRV 177 Query: 214 WDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 W + S + H G ++ + + H+++ D + LW Sbjct: 178 WKIPEESQLV-----------------FYGHQGSIDCIHLI-NEEHMVSGADDGSVALWG 219 Query: 274 SSNGENTLVNYGKVCNNSKKGLKFTVSCGC------SSEFVFVPYGSTIAVYTVYSG-EQ 326 S + + GL+ + + S + ++ G Q Sbjct: 220 LSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQ 279 Query: 327 ITML--KGHYKTVDCCVFQSNFQELYSG 352 + +L ++ F S+ L +G Sbjct: 280 LDLLCDIPLVGFINSLKFSSSGDFLVAG 307 Score = 101 bits (251), Expect = 5e-22, Method: Composition-based stats. Identities = 49/286 (17%), Positives = 96/286 (33%), Gaps = 45/286 (15%) Query: 97 VHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN-------FEETVYSHH- 148 H+ S+ + P D+ +F S++ D ++ W + + V + +S H Sbjct: 12 GHQLSITCLVVTPDDSAIF-SAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHV 70 Query: 149 -MSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASA 207 +S+ +A G R + + + +S + GHR + +++ R + L + S Sbjct: 71 LCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFR-RGTHQLYSTSH 129 Query: 208 DSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDN 267 D VK+W+V + H V L S + G D Sbjct: 130 DRSVKVWNV----------------AENSYVETLFGHQDAVAALDALSRECCVTAGGRDG 173 Query: 268 RMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQI 327 +R+W E+ LV YG S + V ++A++ + + Sbjct: 174 TVRVWKIPE-ESQLVFYG--HQGSIDCIHLI----NEEHMVSGADDGSVALWGLSKKRPL 226 Query: 328 TM------LKGHYK-----TVDCCVFQSNFQELYSGSRDCNILAWV 362 + L+G + N + +GS + W Sbjct: 227 ALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQ 272 Score = 101 bits (251), Expect = 6e-22, Method: Composition-based stats. Identities = 49/330 (14%), Positives = 112/330 (33%), Gaps = 46/330 (13%) Query: 13 EDPLRLRRAESTRRV--LGLELNKDRDV-----------ERIHGGGINTLDIEPVEGRYM 59 D + A + +E + V H + + I +G+Y+ Sbjct: 24 PDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAIS-SDGKYL 82 Query: 60 LSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSS 119 SG +I++++ ++ +T HR +V + + T S+S Sbjct: 83 ASGDRSKLILIWEAQSCQHLYTFTG-------------HRDAVSGLAFR-RGTHQLYSTS 128 Query: 120 FDKTLKVWDT-NTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSC 178 D+++KVW+ +F ++ V + ++ C V G R V++ + S Sbjct: 129 HDRSVKVWNVAENSYVETLFGHQDAVAAL---DALSRECCVTAGGRDGTVRVWKIPEESQ 185 Query: 179 SHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVE 238 + GH+ I + + + + + D V LW + + + + H + +E Sbjct: 186 L-VFYGHQGSIDCIHL--INEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLE 242 Query: 239 SANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFT 298 ++ + + + T + +RLW G +C+ G + Sbjct: 243 QPF-----WISSVAALLNTDLVATGSHSSCVRLWQCGEG---FRQLDLLCDIPLVGFINS 294 Query: 299 VSCGCSSEFVFVPYGSTIAV---YTVYSGE 325 + S +F+ G + + + Sbjct: 295 LKFSSSGDFLVAGVGQEHRLGRWWRIKEAR 324 Score = 97.7 bits (241), Expect = 8e-21, Method: Composition-based stats. Identities = 40/241 (16%), Positives = 79/241 (32%), Gaps = 35/241 (14%) Query: 145 YSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQ-----------GHRQEILAVS 193 S V+ + + + ++SG H++ GH +L ++ Sbjct: 15 LSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMA 74 Query: 194 WSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCF 253 S Y LA+ + +W+ ++ L T T H V+GL F Sbjct: 75 ISSDGKY-LASGDRSKLILIWEA-QSCQHLYTF---------------TGHRDAVSGLAF 117 Query: 254 TSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYG 313 L + D +++WN + +G + + + Sbjct: 118 RRGTHQLYSTSHDRSVKVWNVAENSYVETLFGH-----QDAVAALDALSRECCVTAGGRD 172 Query: 314 STIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDD 373 T+ V+ + Q+ GH ++DC + + SG+ D ++ W S P+ Sbjct: 173 GTVRVWKIPEESQLVFY-GHQGSIDCIHLINEEH-MVSGADDGSVALWGLSKKRPLALQR 230 Query: 374 E 374 E Sbjct: 231 E 231 Score = 91.9 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 33/183 (18%), Positives = 67/183 (36%), Gaps = 11/183 (6%) Query: 179 SHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVE 238 +L+GH+ I + +P I +A+ D + W V + G + + Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIF-SAAKDCSIIKWSVESGRKLHVIPRAKKGAEGK--- 62 Query: 239 SANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFT 298 H+ V + +SDG +L + + +W + + ++ G ++ GL F Sbjct: 63 --PPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTG--HRDAVSGLAFR 118 Query: 299 VSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNI 358 + + + ++ V+ V + L GH V S + +G RD + Sbjct: 119 RG---THQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTV 175 Query: 359 LAW 361 W Sbjct: 176 RVW 178 Score = 70.3 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 25/129 (19%), Positives = 42/129 (32%), Gaps = 8/129 (6%) Query: 243 AHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLV-------NYGKVCNNSKKGL 295 H + L T D + + D + W+ +G V GK +S L Sbjct: 12 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 71 Query: 296 KFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRD 355 +S I ++ S + + GH V F+ +LYS S D Sbjct: 72 CMAISSD-GKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHD 130 Query: 356 CNILAWVPS 364 ++ W + Sbjct: 131 RSVKVWNVA 139 Score = 67.3 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 36/237 (15%), Positives = 77/237 (32%), Gaps = 36/237 (15%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 L + + +V + N + H + LD E GG DG + ++ + Sbjct: 124 LYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTA-GGRDGTVRVWKIPE 182 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 S+ +Y H+ S++ + + + S + D ++ +W + + Sbjct: 183 ESQLVFY--------------GHQGSIDCI--HLINEEHMVSGADDGSVALWGLSKKRPL 226 Query: 136 DVFNFEETVYSH---------HMSPVSTKHCLVAVGTRGPKVQLCDLKSG------SCSH 180 + + LVA G+ V+L G C Sbjct: 227 ALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDI 286 Query: 181 ILQGHRQEILAVSWSPRYDYILATASADSRV-KLWDVRRASGCLITLDQHNGKKSQA 236 L G I ++ +S D+++A + R+ + W ++ A + + A Sbjct: 287 PLVG---FINSLKFSSSGDFLVAGVGQEHRLGRWWRIKEARNSVCIIPLRRVPVPPA 340 Score = 38.7 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 11/43 (25%), Positives = 23/43 (53%) Query: 327 ITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPV 369 I +L+GH ++ C V + ++S ++DC+I+ W + Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKL 49 >4XFV-A nrPDB Length = 792 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 63/387 (16%), Positives = 119/387 (30%), Gaps = 63/387 (16%) Query: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 + H + + P + +M+S D + ++ + S + + Sbjct: 60 KGHEAEVTCVRFVP-DSDFMVSASEDHHVKIWKFTD------------YSHLQCIQTIQH 106 Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETV-------YSHHMSPV 152 YS V + + D T+ +W N E T+ +S V Sbjct: 107 YSKTIVALSAL-PSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKV 165 Query: 153 STKHCLVAVGTRGPKV-----QLCDLKSGSCSHI--LQGHRQEILAVSWSPR---YDYIL 202 K L+A+G V L D C + L+GH + ++++ + DY+L Sbjct: 166 EEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLL 225 Query: 203 ATASADSRVKLWDVR--------RASGCLITLDQHNGKKSQA---------VESANTAHN 245 + S D ++LW +R +TL + K Q E+ H+ Sbjct: 226 CSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHD 285 Query: 246 GKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCS- 304 ++ L + L LL D + +W V ++ S KG Sbjct: 286 DWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGF 345 Query: 305 -----------SEFVFVPYGSTIAVYTVYSGEQITM---LKGHYKTVDCCVFQSNFQELY 350 F+ + ++ + G K V + + + L Sbjct: 346 WSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLL 405 Query: 351 SGSRDCNILAWVPSLYEPVPDDDETTT 377 + S D + P +Y+ E T Sbjct: 406 ATSLDQTTRLFAPWIYDASGRKREIAT 432 Score = 89.6 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 48/251 (19%), Positives = 87/251 (34%), Gaps = 35/251 (13%) Query: 149 MSPVSTKHCLVAVGTRGPKVQLCDL---KSGSCSHILQGHRQEILAVSWSPRYDYILATA 205 +S + +VA G G + L D + L+GH E+ V + P D+++ +A Sbjct: 24 VSDIHKVKKIVAFG-AGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMV-SA 81 Query: 206 SADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGT 265 S D VK+W S + K + ++ + Sbjct: 82 SEDHHVKIWKFTDYSHLQCIQTIQHYSK---------------TIVALSALPSLISVGCA 126 Query: 266 DNRMRLW--NSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVY---- 319 D + +W N N E L + + L ++S +++ G+ + V+ Sbjct: 127 DGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASF 186 Query: 320 -----TVYSGEQITMLKGHYKTVDCCVF----QSNFQELYSGSRDCNILAWVPSLYEPVP 370 + + L+GH V F L SGS+D I W + + + Sbjct: 187 ILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLID 246 Query: 371 DDDETTTKSQL 381 D +E + K L Sbjct: 247 DSEEDSKKLTL 257 Score = 69.6 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 61/373 (16%), Positives = 107/373 (28%), Gaps = 67/373 (17%) Query: 43 GGGINTLDIEPVEGRYMLSGGSDGVIVL---YDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 + + P G Y+L+ D L + + S R+ S P +H Sbjct: 389 TKDVTDIAWSP-SGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFS----RPQIHG 443 Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLV 159 Y + V+ F S +K L+ +D A + + S + + Sbjct: 444 YDMICVE--TVTDTRFVSGGDEKILRSFDLPKG-VAGMLQKFVGIQFEEKSEMPDSATVP 500 Query: 160 AVGTRGP-------------------KVQLCDLKS----------------GSCSHILQG 184 +G + D S L G Sbjct: 501 VLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYG 560 Query: 185 HRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAH 244 H EI + SP ++A+A + V+ T + K + H Sbjct: 561 HGFEITCLDISPD-QKLIASACRSNNVQ----NAVIRIFSTENWLEIKPALPF------H 609 Query: 245 NGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCG-- 302 + + L F+ DG LL+V D + LW + +NT K + + Sbjct: 610 SLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLE 669 Query: 303 CSSEFVFVPYGSTIAVYTVYSG----EQITMLKGHYKTVDCCVFQSN---FQELYS-GSR 354 + FV T+ V+ + H K V + + L S G Sbjct: 670 FGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLE 729 Query: 355 DCNILAWVPSLYE 367 + I + +L + Sbjct: 730 NGEIYLYSYTLGK 742 Score = 59.2 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 37/258 (14%), Positives = 88/258 (34%), Gaps = 38/258 (14%) Query: 34 KDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRD 93 + + HG I LDI P + + + S + + S +++ K Sbjct: 553 PEVEKLYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPF--- 608 Query: 94 HPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVW------DTNTLQTADVFNFEETVYSH 147 H ++ +++ D S D+ +W +T L+ + ++ Sbjct: 609 ----HSLTITRLKFS-KDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDA 663 Query: 148 HMSPVSTKHCLVAVGTRGPKVQLC-DLKSGSCSHILQG---HRQEILAVSWSP---RYDY 200 +P+ + V +R V++ K + ++L+ H + + A+S R Sbjct: 664 DWAPLEFGNVFV-TASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKI 722 Query: 201 ILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFT---SDG 257 +++ + + L+ LIT + + K+ L ++ +G Sbjct: 723 LISVGLENGEIYLYSYTLGKFELITQLNEDITPA-----------DKITRLRWSHLKRNG 771 Query: 258 LHLL-TVGTDNRMRLWNS 274 L +D R+++ Sbjct: 772 KLFLGVGSSDLSTRIYSL 789 >4L9O-A nrPDB Length = 349 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 45/278 (16%), Positives = 101/278 (36%), Gaps = 39/278 (14%) Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQW-YPHDTGM 114 GR + + SD I +++++ +++ T H V V W +P + Sbjct: 81 GRRLATCSSDKTIKIFEIDGENQRLVETLIG-----------HEGPVWQVAWAHPKFGVI 129 Query: 115 FTSSSFDKTLKVWDTNTL---QTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLC 171 S S+D + +W + + A+ + +V S +P L+ + K+ + Sbjct: 130 LASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCA-SSDGKISIV 188 Query: 172 DLKSGSCSH--ILQGHRQEILAVSWSP----RYDYILATASADSRVKLWDVRRASGCLIT 225 + K G ++QGH + A SW+P + D+ VK+W A+ I Sbjct: 189 EFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIE 248 Query: 226 LDQHNGKKSQAVESANTAHNGKVNGLCFTS---DGLHLLTVGTDNRMRLWNSSNGENTLV 282 + H+ V + ++ ++ T D + +W + +G++ Sbjct: 249 EEA------------FQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIW-TKDGKSNKW 295 Query: 283 NYGKVCNNSKKGLKFTVSCGCSSEFVFVPYG-STIAVY 319 + + + S S + + G + + ++ Sbjct: 296 EKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLW 333 Score = 99.2 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 55/277 (19%), Positives = 96/277 (34%), Gaps = 41/277 (14%) Query: 16 LRLRRAESTRRVLGLELNKDRDVER--IHGGGINTLDI-EPVEGRYMLSGGSDGVIVLYD 72 L ++ T ++ ++ R VE H G + + P G + S DG ++++ Sbjct: 84 LATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWK 143 Query: 73 LENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG-MFTSSSFDKTLKVW---D 128 +N VH+ SV +V W PH+ G + +S D + + D Sbjct: 144 EDNGVWNKVAE-----------HSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKD 192 Query: 129 TNTLQTADVFNFEETVYSHHMSPVS--TKHCLVAVGTRGPKVQLC--DLKSGSCS--HIL 182 L+ + V + +P+S G V++ D + + Sbjct: 193 GGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAF 252 Query: 183 QGHRQEILAVSWSPR--YDYILATASADSRVKLW--DVRRASGCLITLDQHNGKKSQAVE 238 QGH + V+WSP +ATAS D V +W D + L + Sbjct: 253 QGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFP------ 306 Query: 239 SANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 ++ G L G DN++ LW + Sbjct: 307 -------DVCWRASWSLSGNVLAISGGDNKVTLWKEN 336 Score = 96.5 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 36/248 (14%), Positives = 81/248 (32%), Gaps = 28/248 (11%) Query: 159 VAVGTRGPKVQLC--DLKSGSCSHILQGHRQEILAVSW-SPRYDYILATASADSRVKLWD 215 +A + +++ D ++ L GH + V+W P++ ILA+ S D +V +W Sbjct: 84 LATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWK 143 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD--GLHLLTVGTDNRMRLWN 273 + + ++ H VN + + G LL +D ++ + Sbjct: 144 EDNGVWNKV--------------AEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVE 189 Query: 274 SSNGENTLVNYGKVCNNSKKGLKFTVSC--GCSSEFVFVPYGSTIAVYTVYSGEQI---- 327 +G + + + FV + + ++ + Sbjct: 190 FKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEE 249 Query: 328 TMLKGHYKTVDCCVFQSN---FQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPA 384 +GH V + + + + S+D +L W + T + + Sbjct: 250 EAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVC 309 Query: 385 FEDAWSSS 392 + +WS S Sbjct: 310 WRASWSLS 317 Score = 78.4 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 36/218 (16%), Positives = 69/218 (31%), Gaps = 26/218 (11%) Query: 184 GHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTA 243 H I LAT S+D +K++++ + L+ Sbjct: 67 AHDDLIHDAVLDYYGR-RLATCSSDKTIKIFEIDGENQRLVE--------------TLIG 111 Query: 244 HNGKVNGLCFT--SDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSC 301 H G V + + G+ L + D ++ +W NG V V S + + Sbjct: 112 HEGPVWQVAWAHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPH- 170 Query: 302 GCSSEFVFVPYGSTIAVYTVYSGEQIT--MLKGHYKTVDCCVFQS-----NFQELYSGSR 354 + I++ G + +++GH V+ + N + SG Sbjct: 171 EYGPVLLCASSDGKISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGC 230 Query: 355 DCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSSS 392 D + W ++E + + + AWS S Sbjct: 231 DNLVKIWRYDDAAKTFIEEE-AFQGHSDWVRDVAWSPS 267 Score = 52.6 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 20/151 (13%), Positives = 42/151 (27%), Gaps = 5/151 (3%) Query: 214 WDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 +D S I + G + AH+ ++ G L T +D ++++ Sbjct: 38 FDTYGQSKVEINIVGSGGGSGGGSVTIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFE 97 Query: 274 SSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQ--ITMLK 331 LV + + Y + ++ +G + Sbjct: 98 IDGENQRLVETLIGHEGPVWQVAW-AHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHS 156 Query: 332 GHYKTVDCCVFQSN--FQELYSGSRDCNILA 360 H +V+ + + L S D I Sbjct: 157 VHQASVNSVSWAPHEYGPVLLCASSDGKISI 187 >5OQL-J nrPDB Length = 912 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 75/400 (18%), Positives = 121/400 (30%), Gaps = 75/400 (18%) Query: 11 GLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRY-MLSGGSDGVIV 69 + P A+ G+ L R + H ++ I P + + + D IV Sbjct: 347 RVPSP-----ADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIV 401 Query: 70 LYDLENSSRQSYYTCKAVCSIGRDHP--DVHRYSVE--TVQWYPHDTGMFTSSSFDKTLK 125 + + C++ G D H V V W S S D T + Sbjct: 402 SVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWS---GHWIASGSKDNTAR 458 Query: 126 VWDT----NTLQTADVFNFEETVYSH--------------HMSPVSTKHCLVAVGTRGPK 167 +W N+ VF +P+ + G++ Sbjct: 459 LWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRF 518 Query: 168 VQLCDL-----KSGSCSHILQ--GHRQEILAVSWSPRYDYILATASADSRVKLWDVRRAS 220 VQ D+ K G + L+ H ++I A+ SP + A+AS D VK+WDV + Sbjct: 519 VQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNG-KLFASASQDKTVKIWDVEK-- 575 Query: 221 GCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGL--------------HLLTVGTD 266 V+ H V + F +LT D Sbjct: 576 --------------LEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGD 621 Query: 267 NRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCS-----SEFVFVPYGSTIAVYTV 321 ++LWN S+ G N K + +S S +F + + V+ Sbjct: 622 KTIKLWNLSDYTCIRTFEGHSHN-VLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDA 680 Query: 322 YSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 +GE L H + S L S D + W Sbjct: 681 NTGETECTLDNHEDRLWTLAVHSKTNILASAGSDSKVTFW 720 Score = 108 bits (268), Expect = 6e-24, Method: Composition-based stats. Identities = 44/213 (20%), Positives = 72/213 (33%), Gaps = 9/213 (4%) Query: 41 IHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRY 100 H IN LDI P G+ S D + ++D+E Q ++ Sbjct: 542 AHDKDINALDISP-NGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTP 600 Query: 101 SVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFE-----ETVYSHHMSPVS-- 153 ++ Q G+ + S DKT+K+W+ + F + V+ H S Sbjct: 601 VIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSIT 660 Query: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKL 213 A V++ D +G L H + ++ + + ILA+A +DS+V Sbjct: 661 KTKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTN-ILASAGSDSKVTF 719 Query: 214 WDVRRASGCLITLDQHNGKKSQAVESANTAHNG 246 W A Q N H G Sbjct: 720 WRDTTAETQAAAAQAALKLVEQEQTLENYIHAG 752 Score = 79.2 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 34/252 (13%), Positives = 76/252 (30%), Gaps = 42/252 (16%) Query: 142 ETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYI 201 + +Y+ + ++A T G L +L +G +QG + I ++ +P ++ Sbjct: 18 QPIYTGGSVALENGARILAS-TLGENAILTELNTGKRLAEIQGDGEPISTLTITPSGSHL 76 Query: 202 LATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLL 261 + S ++++ + + + H V L L Sbjct: 77 IV-CSRSLTMRIYSL--------AISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLA 127 Query: 262 TVGTDNRMRLWN--------SSNGENTLVNYGKVCNNSKKGLKFTVSCGCSS-------- 305 T D +++W+ + +G + LV+ + + + Sbjct: 128 TGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQND 187 Query: 306 ---------EFVFVPYGSTIAVYTVYSG-------EQITMLKGHYKTVDCCVFQSNFQEL 349 + I ++ +Y + + H V C + L Sbjct: 188 DADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHAL 247 Query: 350 YSGSRDCNILAW 361 SGSRD + W Sbjct: 248 LSGSRDKTMTLW 259 Score = 77.3 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 47/333 (14%), Positives = 107/333 (32%), Gaps = 57/333 (17%) Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVW------DTNTLQTADVFNFEETVYSHHMSPVS 153 + T+ P + + S T++++ D ++++ V + + V Sbjct: 62 EPISTLTITPSGSHLIV-CSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVD 120 Query: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSW------------------- 194 L+A G +++ D+ G +H + G + A+ + Sbjct: 121 RTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKG 180 Query: 195 -----SPRYDYI-----LATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAH 244 + D I LA + D R++++D+ + + + D K+ AH Sbjct: 181 SRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKE---------AH 231 Query: 245 NGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCS 304 V + ++ + LL+ D M LW +G + + L+ Sbjct: 232 ESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLR-----HELLESVGFLNEG 286 Query: 305 SEFVFVPYGSTIAVYTVYSGEQITM---LKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 + ++ + +IT K + + V + D ++ + Sbjct: 287 KWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLVLY 346 Query: 362 VPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDE 394 P P D ++++ L F + DE Sbjct: 347 RV----PSPADVVSSSEGILLEPFRRISGTHDE 375 >6BX3-A nrPDB Length = 314 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 45/324 (13%), Positives = 102/324 (31%), Gaps = 37/324 (11%) Query: 47 NTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQ 106 I P ++ G + I++YD+ + + + H + Sbjct: 16 TCAKISPDGQFLAITQGLN--ILIYDINRRT------------VSQTLVTSHARPFSELC 61 Query: 107 WYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGP 166 W P D ++S D ++++ + V S + K L+ + Sbjct: 62 WSP-DGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFN---RKGNLLFTSSMDE 117 Query: 167 KVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITL 226 +++ D +GS + H + +++V IL++ S D ++++D CL TL Sbjct: 118 SIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAET-GHCLKTL 176 Query: 227 DQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGK 286 K + ++ + F+ + +LL D +++W+ G + Sbjct: 177 TYDKDWKRENGVV-------PISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQ 229 Query: 287 VCNNSKKGLKF-----TVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKG----HYKTV 337 G + + I + + + +L G H V Sbjct: 230 PLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPV 289 Query: 338 DCCVFQSNFQELYSGSRDCNILAW 361 + S + + + W Sbjct: 290 MSI--HCFGNIMCSLALNGDCCLW 311 Score = 82.3 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 33/212 (15%), Positives = 70/212 (33%), Gaps = 23/212 (10%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 L + + ++ H + ++D+ + + SG DG+I ++D E Sbjct: 110 LFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAET 169 Query: 76 SSRQSYYTCKAVCSIGRDHP-DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQT 134 C + +D + + V++ + S D +K+WD Sbjct: 170 G------HCLKTLTYDKDWKRENGVVPISQVKFS-ENARYLLVKSLDGVVKIWDCIGGCV 222 Query: 135 ADVF---NFEETVYSHHM-----SPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQG-- 184 F E+ V H +P LV G + + + S +L G Sbjct: 223 VRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSL 282 Query: 185 --HRQEILAVSWSPRYDYILATASADSRVKLW 214 H ++++ + I+ + + + LW Sbjct: 283 YHHSSPVMSI---HCFGNIMCSLALNGDCCLW 311 Score = 65.3 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 26/180 (14%), Positives = 60/180 (33%), Gaps = 28/180 (15%) Query: 190 LAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVN 249 SP ++ T + + ++D+ R + ++ T+H + Sbjct: 16 TCAKISPDGQFLAITQGLN--ILIYDINRRT---------------VSQTLVTSHARPFS 58 Query: 250 GLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNN-SKKGLKFTVSCGCSSEFV 308 LC++ DG + T D + + ++YG + +++ + Sbjct: 59 ELCWSPDGQCIATASDDFSVEI--------IHLSYGLLHTFIGHTAPVISLTFNRKGNLL 110 Query: 309 FVPY-GSTIAVYTVYSGEQITMLKGHYKTVDCCVF-QSNFQELYSGSRDCNILAWVPSLY 366 F +I ++ +G + + H + V ++ L SGS D I + Sbjct: 111 FTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG 170 Score = 41.4 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 14/78 (17%), Positives = 29/78 (37%), Gaps = 2/78 (2%) Query: 291 SKKGLKFTVS-CGCSSEFVFVPYGSTIAVYTVYSGEQITML-KGHYKTVDCCVFQSNFQE 348 ++ GLK T + +F+ + G I +Y + L H + + + Q Sbjct: 9 TQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQC 68 Query: 349 LYSGSRDCNILAWVPSLY 366 + + S D ++ S Sbjct: 69 IATASDDFSVEIIHLSYG 86 >5A31-R nrPDB Length = 386 Score = 115 bits (286), Expect = 5e-26, Method: Composition-based stats. Identities = 44/211 (20%), Positives = 81/211 (38%), Gaps = 37/211 (17%) Query: 8 RQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGV 67 R + DP T+ V GL+ N V + SGG+D V Sbjct: 198 RDVRMPDPFFETIESHTQEVCGLKWN--------------------VADNKLASGGNDNV 237 Query: 68 IVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTS--SSFDKTLK 125 + +Y E +S+ T D H+ +V+ + W PH G+ + + D+ LK Sbjct: 238 VHVY--EGTSKSPILTF-----------DEHKAAVKAMAWSPHKRGVLATGGGTADRRLK 284 Query: 126 VWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGH 185 +W+ NT + + + + +T + + G + L D S IL+GH Sbjct: 285 IWNVNTSIKMSDIDSGSQI-CNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGH 343 Query: 186 RQEILAVSWSPRYDYILATASADSRVKLWDV 216 +L ++ S + + + D ++ W + Sbjct: 344 SFRVLHLTLSNDG-TTVVSGAGDETLRYWKL 373 Score = 104 bits (259), Expect = 7e-23, Method: Composition-based stats. Identities = 53/289 (18%), Positives = 101/289 (34%), Gaps = 47/289 (16%) Query: 105 VQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTR 164 + W D + + K++ + D NT + + E S + +AVG Sbjct: 98 IDWSSTD---VLAVALGKSIFLTDNNTGDVVHLCDTENEYTSLSWIGAGSH---LAVGQA 151 Query: 165 GPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLI 224 V++ D+ C L GH + +SW+ +++L + S D R+ DVR Sbjct: 152 NGLVEIYDVMKRKCIRTLSGHIDRVACLSWN---NHVLTSGSRDHRILHRDVRMPDPFFE 208 Query: 225 TLDQHNGKK---------------------------SQAVESANTAHNGKVNGLCFTSDG 257 T++ H + S++ H V + ++ Sbjct: 209 TIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHK 268 Query: 258 LHLLTVG---TDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGS 314 +L G D R+++WN + +S + V ++E V S Sbjct: 269 RGVLATGGGTADRRLKIWNVNTSIKMSDI------DSGSQICNMVWSKNTNELVTSHGYS 322 Query: 315 --TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 + ++ S + I +LKGH V ++ + SG+ D + W Sbjct: 323 KYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYW 371 Score = 78.4 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 49/252 (19%), Positives = 85/252 (33%), Gaps = 54/252 (21%) Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMF 115 G ++ G ++G++ +YD+ H V + W H + Sbjct: 143 GSHLAVGQANGLVEIYDVMKRKCIRTL-------------SGHIDRVACLSWNNH---VL 186 Query: 116 TSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCL----VAVGTRGPKVQLC 171 TS S D + D F ET+ SH K + +A G V + Sbjct: 187 TSGSRDHRILHRDVRM-----PDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVY 241 Query: 172 DLKSGSCSHILQGHRQEILAVSWSPRYDYILATASA--DSRVKLWDVRRA---------- 219 + S S H+ + A++WSP +LAT D R+K+W+V + Sbjct: 242 EGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGS 301 Query: 220 -------SGCLITLDQHNGKKSQAVESAN----------TAHNGKVNGLCFTSDGLHLLT 262 S L +G + + H+ +V L ++DG +++ Sbjct: 302 QICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVS 361 Query: 263 VGTDNRMRLWNS 274 D +R W Sbjct: 362 GAGDETLRYWKL 373 Score = 44.1 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 32/180 (17%), Positives = 67/180 (37%), Gaps = 14/180 (7%) Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 V S L+ Q + +++ + A + + + ++S + + +G + L +++ Sbjct: 63 VSNKSQKLLRSRQIAKVPYRVLDAPSLADDFYYSLIDWSSTDVLAVALGK--SIFLTDNN 120 Query: 276 NGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYK 335 G+ +C+ + + G S + +Y V + I L GH Sbjct: 121 TGDVV-----HLCDTENEYTSLS-WIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHID 174 Query: 336 TVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDEE 395 V C + N L SGSRD + P P + + +Q + W+ +D + Sbjct: 175 RVACLSW--NNHVLTSGSRDH--RILHRDVRMPDPFFETIESHTQEVCGLK--WNVADNK 228 Score = 43.8 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 17/131 (12%), Positives = 39/131 (29%), Gaps = 8/131 (6%) Query: 245 NGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCS 304 + L + G HL + + +++ + G + + L + + Sbjct: 131 ENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHI--DRVACLSWN-----N 183 Query: 305 SEFVFVPYGSTIAVYTVYSGEQI-TMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVP 363 I V + ++ H + V + +L SG D + + Sbjct: 184 HVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEG 243 Query: 364 SLYEPVPDDDE 374 + P+ DE Sbjct: 244 TSKSPILTFDE 254 >3W15-A nrPDB Length = 368 Score = 114 bits (285), Expect = 6e-26, Method: Composition-based stats. Identities = 50/291 (17%), Positives = 105/291 (36%), Gaps = 30/291 (10%) Query: 13 EDPLRLRRAESTRRVLGLELNKD-RDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLY 71 E+ + + + + T R+ + + + H + + + V + LS DG I ++ Sbjct: 75 ENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIW 134 Query: 72 D---------LENSSRQSYYTCKAVCSIGRDHPDVHRYS-----VETVQWYPHDTGMFTS 117 L + + +I S V Q+ PHD + S Sbjct: 135 SPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLS 194 Query: 118 SSFDKTLKVWD--TNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLK- 174 S + ++D + + + F + + + +VA G +++ D++ Sbjct: 195 CSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRM 254 Query: 175 ---------SGSCSHILQ-GHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLI 224 + SC + + H I V+WSP + IL +AS D ++W G Sbjct: 255 LNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKE 314 Query: 225 TLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGL--HLLTVGTDNRMRLWN 273 T ++ ++ T H+ V G ++ G ++ + D + +WN Sbjct: 315 TYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 Score = 82.3 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 47/371 (12%), Positives = 106/371 (28%), Gaps = 76/371 (20%) Query: 47 NTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQ 106 + P + + L + + I + + + + + Sbjct: 14 YGVQYSPFFDNRLAVAAGSN----FGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLA 69 Query: 107 WYPHDTGMFTSSSFDKTLKVWDTNTLQ-TADVFN-FEETVYSHHMSPVSTKHCLVAVGTR 164 W + D TL+++DT + +F E V+S + + V+ ++ L + Sbjct: 70 WNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFL--SSSW 127 Query: 165 GPKVQLCDLKSGSCSHILQG---------------------------HRQEILAVSWSPR 197 +++ L +R + +SP Sbjct: 128 DGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPH 187 Query: 198 YDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNG-KVNGLCFTSD 256 ++ + S +S L+D+R S ++ H+G + F Sbjct: 188 DQNLVLSCSGNSYASLFDIR--------------LPSGKNQNNFLVHSGLEALTCDFNKY 233 Query: 257 GLHLL-TVGTDNRMRLWNSSN-GENTLVNYGKVC-----NNSKKGLKFTVSCGCSSEFV- 308 +++ T G DN +R+W+ +N + C N ++ S + Sbjct: 234 RPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILM 293 Query: 309 FVPYGSTIAVYT----------------VYSGEQITMLKGHYKTVDCCVFQSNFQ--ELY 350 Y T ++ + I H + V + + + Sbjct: 294 SASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVA 353 Query: 351 SGSRDCNILAW 361 S + D N+ W Sbjct: 354 STAWDGNLFVW 364 Score = 55.3 bits (131), Expect = 5e-08, Method: Composition-based stats. Identities = 34/263 (12%), Positives = 76/263 (28%), Gaps = 50/263 (19%) Query: 145 YSHHMSPVSTKHCLVAVGTRGPKV------QLCDLKSGSCSHILQGHRQE-ILAVSWSPR 197 Y SP VA G+ V L +SG + Q+ + ++W+ Sbjct: 14 YGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNES 73 Query: 198 YDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFT-SD 256 ++ + A D ++L+D + + H +V + + Sbjct: 74 HENQVLVAQGDGTLRLFDTTFKEFPIAIFKE---------------HEREVFSCNWNLVN 118 Query: 257 GLHLLTVGTDNRMRLWNSSNGENTLV-----------------------NYGKVCNNSKK 293 + L+ D +++W+ ++ + ++ + N Sbjct: 119 RQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNC 178 Query: 294 GLKFTVSCGCSSEFVFVPYGSTIAVYTVY--SGEQITMLKGHYK-TVDCCVFQSNFQELY 350 + S + + S +++ + SG+ H C F + Sbjct: 179 VYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVV 238 Query: 351 -SGSRDCNILAWVPSLYEPVPDD 372 +G D I W + P Sbjct: 239 ATGGVDNAIRIWDIRMLNKNPGQ 261 >5OQL-d nrPDB Length = 446 Score = 113 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 49/339 (14%), Positives = 115/339 (33%), Gaps = 47/339 (13%) Query: 37 DVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPD 96 + H G+ ++ + + SG DGV+ ++DL +++ Sbjct: 60 QLGNGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRV------------A 107 Query: 97 VHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVS--T 154 H V+ + + + S + D +K+WD ++ + +S Sbjct: 108 AHNNIVKGLTF--TNDKKLLSCATDG-IKLWD-PYASPSNTTPIATWQEGGPYTSLSFHR 163 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQ--GHRQEILAVSWSPRYDYILATASADSRVK 212 A + +++ DL+ + +Q I V ++ ++ + + D + Sbjct: 164 SANTFAASSGQGCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSII 223 Query: 213 LWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS-DGLHLLTVGTDNRMRL 271 L+D+R + T+ N + F + ++L D+ + + Sbjct: 224 LFDLRTNMPVIKTVLHFA-----------------CNRIVFNPMEAMNLAVASEDHNIYI 266 Query: 272 WNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLK 331 +++ N + L + + E V Y TI ++ +G + Sbjct: 267 FDARNFDKAL----NIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVY- 321 Query: 332 GHYKT---VDCCVFQSNFQELYSGSRDCNILAWVPSLYE 367 H K V ++ + + + +GS D N+ W + E Sbjct: 322 -HTKRMQRVFRTMWTMDSKYILTGSDDGNVRLWRANASE 359 Score = 113 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 52/315 (16%), Positives = 104/315 (33%), Gaps = 42/315 (13%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERI--HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDL 73 + + +V L +D + R+ H + L + +LS +DG I L+D Sbjct: 82 IASGSGDGVVKVWDL-TTRDEETWRVAAHNNIVKGLTFT--NDKKLLSCATDG-IKLWD- 136 Query: 74 ENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNT-- 131 Y + + + ++ ++ F +SS +++WD Sbjct: 137 -------PYASPSNTTPIATWQEG--GPYTSLSFH-RSANTFAASSGQGCIRIWDLEHST 186 Query: 132 -LQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEIL 190 Q +F +T+ + V T ++ + L DL++ H Sbjct: 187 AGQAIQWPSFVDTITDVCFNQVET--SVIGSVATDRSIILFDLRTNMPVIKTVLHFA-CN 243 Query: 191 AVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNG 250 + ++P LA AS D + ++D R L + H V Sbjct: 244 RIVFNPMEAMNLAVASEDHNIYIFDARNFDKAL---------------NIQKGHVAAVMD 288 Query: 251 LCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFV 310 + F+ G L++ D +RLW G + V + K + T+ S + Sbjct: 289 VEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQRVFR----TMWTMDSKYILTG 344 Query: 311 PYGSTIAVYTVYSGE 325 + ++ + E Sbjct: 345 SDDGNVRLWRANASE 359 Score = 100 bits (249), Expect = 9e-22, Method: Composition-based stats. Identities = 47/277 (16%), Positives = 95/277 (34%), Gaps = 34/277 (12%) Query: 14 DPLRLRRAESTRRVLGLELNKDRDVERI---HGGGINTLDIEPVEGRYMLSGGSDGVIVL 70 D L A ++ + GG +L + S G G I + Sbjct: 121 DKKLLSCATDGIKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQ-GCIRI 179 Query: 71 YDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN 130 +DLE + P ++ V + +T + S + D+++ ++D Sbjct: 180 WDLE----------HSTAGQAIQWPSF-VDTITDVCFNQVETSVIGSVATDRSIILFDLR 228 Query: 131 TLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSG-SCSHILQGHRQEI 189 T +P+ + +AV + + + D ++ +I +GH + Sbjct: 229 TNMPVIKTVLHFACNRIVFNPMEAMN--LAVASEDHNIYIFDARNFDKALNIQKGHVAAV 286 Query: 190 LAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVN 249 + V +SP + L + S D ++LW + +T +V Sbjct: 287 MDVEFSPTGEE-LVSGSYDRTIRLWRRDAGHSR---------------DVYHTKRMQRVF 330 Query: 250 GLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGK 286 +T D ++LT D +RLW ++ E + V + Sbjct: 331 RTMWTMDSKYILTGSDDGNVRLWRANASERSGVKATR 367 Score = 58.8 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 19/138 (13%), Positives = 49/138 (35%), Gaps = 15/138 (10%) Query: 16 LRLRRAESTRRVLGLE-LNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLE 74 L + + + +K ++++ H + ++ P G ++SG D I L+ + Sbjct: 255 LAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPT-GEELVSGSYDRTIRLWRRD 313 Query: 75 NSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQT 134 + Y K + + R + D+ + S D +++W N + Sbjct: 314 AGHSRDVYHTKRMQRVFRTMWTM-------------DSKYILTGSDDGNVRLWRANASER 360 Query: 135 ADVFNFEETVYSHHMSPV 152 + V + + + + Sbjct: 361 SGVKATRQRQALEYNNAL 378 >4BH6-A nrPDB Length = 308 Score = 113 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 44/211 (20%), Positives = 81/211 (38%), Gaps = 37/211 (17%) Query: 8 RQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGV 67 R + DP T+ V GL+ N V + SGG+D V Sbjct: 129 RDVRMPDPFFETIESHTQEVCGLKWN--------------------VADNKLASGGNDNV 168 Query: 68 IVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTS--SSFDKTLK 125 + +Y E +S+ T D H+ +V+ + W PH G+ + + D+ LK Sbjct: 169 VHVY--EGTSKSPILTF-----------DEHKAAVKAMAWSPHKRGVLATGGGTADRRLK 215 Query: 126 VWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGH 185 +W+ NT + + + + +T + + G + L D S IL+GH Sbjct: 216 IWNVNTSIKMSDIDSGSQI-CNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGH 274 Query: 186 RQEILAVSWSPRYDYILATASADSRVKLWDV 216 +L ++ S + + + D ++ W + Sbjct: 275 SFRVLHLTLSNDG-TTVVSGAGDETLRYWKL 304 Score = 102 bits (254), Expect = 3e-22, Method: Composition-based stats. Identities = 53/289 (18%), Positives = 101/289 (34%), Gaps = 47/289 (16%) Query: 105 VQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTR 164 + W D + + K++ + D NT + + E S + +AVG Sbjct: 29 IDWSSTD---VLAVALGKSIFLTDNNTGDVVHLCDTENEYTSLSWIGAGSH---LAVGQA 82 Query: 165 GPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLI 224 V++ D+ C L GH + +SW+ +++L + S D R+ DVR Sbjct: 83 NGLVEIYDVMKRKCIRTLSGHIDRVACLSWN---NHVLTSGSRDHRILHRDVRMPDPFFE 139 Query: 225 TLDQHNGKK---------------------------SQAVESANTAHNGKVNGLCFTSDG 257 T++ H + S++ H V + ++ Sbjct: 140 TIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHK 199 Query: 258 LHLLTVG---TDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGS 314 +L G D R+++WN + +S + V ++E V S Sbjct: 200 RGVLATGGGTADRRLKIWNVNTSIKMSDI------DSGSQICNMVWSKNTNELVTSHGYS 253 Query: 315 --TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 + ++ S + I +LKGH V ++ + SG+ D + W Sbjct: 254 KYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYW 302 Score = 76.5 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 49/252 (19%), Positives = 85/252 (33%), Gaps = 54/252 (21%) Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMF 115 G ++ G ++G++ +YD+ H V + W H + Sbjct: 74 GSHLAVGQANGLVEIYDVMKRKCIRTL-------------SGHIDRVACLSWNNH---VL 117 Query: 116 TSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCL----VAVGTRGPKVQLC 171 TS S D + D F ET+ SH K + +A G V + Sbjct: 118 TSGSRDHRILHRDVRM-----PDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVY 172 Query: 172 DLKSGSCSHILQGHRQEILAVSWSPRYDYILATASA--DSRVKLWDVRRA---------- 219 + S S H+ + A++WSP +LAT D R+K+W+V + Sbjct: 173 EGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGS 232 Query: 220 -------SGCLITLDQHNGKKSQAVESAN----------TAHNGKVNGLCFTSDGLHLLT 262 S L +G + + H+ +V L ++DG +++ Sbjct: 233 QICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVS 292 Query: 263 VGTDNRMRLWNS 274 D +R W Sbjct: 293 GAGDETLRYWKL 304 Score = 43.0 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 28/163 (17%), Positives = 62/163 (38%), Gaps = 14/163 (8%) Query: 233 KSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSK 292 + +++ + A + + + ++S + + +G + L +++ G+ +C+ Sbjct: 11 PYRVLDAPSLADDFYYSLIDWSSTDVLAVALGK--SIFLTDNNTGDVV-----HLCDTEN 63 Query: 293 KGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSG 352 + + G S + +Y V + I L GH V C + N L SG Sbjct: 64 EYTSLS-WIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSW--NNHVLTSG 120 Query: 353 SRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDEE 395 SRD + P P + + +Q + W+ +D + Sbjct: 121 SRDH--RILHRDVRMPDPFFETIESHTQEVCGLK--WNVADNK 159 Score = 43.0 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 17/131 (12%), Positives = 39/131 (29%), Gaps = 8/131 (6%) Query: 245 NGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCS 304 + L + G HL + + +++ + G + + L + + Sbjct: 62 ENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHI--DRVACLSWN-----N 114 Query: 305 SEFVFVPYGSTIAVYTVYSGEQI-TMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVP 363 I V + ++ H + V + +L SG D + + Sbjct: 115 HVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEG 174 Query: 364 SLYEPVPDDDE 374 + P+ DE Sbjct: 175 TSKSPILTFDE 185 >6CHG-A nrPDB Length = 312 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 41/272 (15%), Positives = 98/272 (36%), Gaps = 19/272 (6%) Query: 95 PDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVST 154 H+ + + W P D+ S S D T+++ + + V S + Sbjct: 50 TTTHKECINCLCWSP-DSKCIASGSEDFTVEITHIIYGRIRRLMGHTAPVISICYN---N 105 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLW 214 K ++ + ++ + SG+ + H ++++ IL++ S D ++++ Sbjct: 106 KGNILCSSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIF 165 Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 D CL TL ++ ++ + F+ +G LL DN ++LW Sbjct: 166 DTES-GHCLKTLTYDKDWIAEDGVV-------PISTVKFSRNGKFLLVKSLDNVVKLWEY 217 Query: 275 SNGENTLVNYGKVCNNSKKGLKFTVSC------GCSSEFVFVPYGSTIAVYTVYSGEQIT 328 + G + + +K LK+ G + ++ V+ VYS + Sbjct: 218 TRGT-VVRTFLWPHQETKAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQ 276 Query: 329 MLKGHYKTVDCCVFQSNFQELYSGSRDCNILA 360 + ++ +++ ++ + S + Sbjct: 277 KIDEKHRNSPLISISASYDKVATLSLNGECNL 308 Score = 90.7 bits (223), Expect = 9e-19, Method: Composition-based stats. Identities = 41/250 (16%), Positives = 78/250 (31%), Gaps = 35/250 (14%) Query: 152 VSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRV 211 +S L+A+ + + + ++ S + H++ I + WSP +A+ S D V Sbjct: 21 ISPDGELIAIC-QNTDMLVYEISSSKMMKLTTTHKECINCLCWSPD-SKCIASGSEDFTV 78 Query: 212 KLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL 271 ++ H V +C+ + G L + D ++ Sbjct: 79 EI-----------------THIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKE 121 Query: 272 WNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLK 331 W+ +G + +S + + SS Y I ++ SG + L Sbjct: 122 WHVLSGTALKT----MSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLT 177 Query: 332 GHYKTV--------DCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPD----DDETTTKS 379 + F N + L S D + W + V ET K Sbjct: 178 YDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKL 237 Query: 380 QLNPAFEDAW 389 + N E + Sbjct: 238 KYNCGLELIY 247 Score = 85.0 bits (208), Expect = 5e-17, Method: Composition-based stats. Identities = 41/294 (13%), Positives = 96/294 (32%), Gaps = 38/294 (12%) Query: 103 ETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTAD-VFNFEETVYSHHMSPVSTKHCLVAV 161 + Q P + + + V++ ++ + +E + SP S +A Sbjct: 17 TSCQISPDGE--LIAICQNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSKC---IAS 71 Query: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASG 221 G+ V++ + G L GH ++++ ++ + + IL ++S D +K W V + Sbjct: 72 GSEDFTVEITHIIYG-RIRRLMGHTAPVISICYNNKGN-ILCSSSMDESIKEWHVLSGTA 129 Query: 222 CLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS-DGLHLLTVGTDNRMRLWNSSNGENT 280 +AH+ V + D L + D +R++++ +G Sbjct: 130 LKT----------------MSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCL 173 Query: 281 LV---NYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITM-LKGHYKT 336 + + + + + + + ++ G + L H +T Sbjct: 174 KTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQET 233 Query: 337 VDCCVFQ-------SNFQ--ELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQL 381 + + + SG+ ++ W V DE S L Sbjct: 234 KAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEKHRNSPL 287 Score = 78.8 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 28/240 (11%), Positives = 80/240 (33%), Gaps = 30/240 (12%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 + + T + + + R + H + ++ +G + S D I + Sbjct: 69 IASGSEDFTVEITHIIYGRIRRLM-GHTAPVISICYN-NKGNILCSSSMDESIKEW---- 122 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 + H +V ++ D+ + +S S+D ++++DT + Sbjct: 123 ---------HVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCL 173 Query: 136 DVFNF------EETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQ-GHRQE 188 + E+ V S + V + V+L + G+ H++ Sbjct: 174 KTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQET 233 Query: 189 ILAVSWS-------PRY-DYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA 240 + ++ P+ D ++ + + + +W+V + ++H ++ ++ Sbjct: 234 KAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEKHRNSPLISISAS 293 Score = 45.7 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 11/86 (12%), Positives = 32/86 (37%) Query: 282 VNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCV 341 + + K + + + E + + + + VY + S + + + H + ++C Sbjct: 2 LQFDKQVLPASGKISTSCQISPDGELIAICQNTDMLVYEISSSKMMKLTTTHKECINCLC 61 Query: 342 FQSNFQELYSGSRDCNILAWVPSLYE 367 + + + + SGS D + Sbjct: 62 WSPDSKCIASGSEDFTVEITHIIYGR 87 >3JRO-A nrPDB Length = 753 Score = 110 bits (275), Expect = 9e-25, Method: Composition-based stats. Identities = 46/304 (15%), Positives = 98/304 (32%), Gaps = 48/304 (15%) Query: 38 VERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDV 97 + H I+ ++ G+ + + SD I ++++E + + T Sbjct: 4 IANAHNELIHDAVLD-YYGKRLATCSSDKTIKIFEVEGETHKLIDTL-----------TG 51 Query: 98 HRYSVETVQW-YPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTK- 155 H V V W +P + S S+D + +W + + + V+S ++ V Sbjct: 52 HEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQI--AVHAVHSASVNSVQWAP 109 Query: 156 ---HCLVAVGTRGPKVQLCDLKSGSCSH--ILQGHRQEILAVSWSP------------RY 198 L+ V + KV + + K + I+ H + + SW+P + Sbjct: 110 HEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKE 169 Query: 199 DYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD-- 256 T AD+ VK+W ++ +ES H+ V + ++ Sbjct: 170 SRKFVTGGADNLVKIWKYNS------------DAQTYVLESTLEGHSDWVRDVAWSPTVL 217 Query: 257 -GLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGST 315 +L +V D +W N + L + + Sbjct: 218 LRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNK 277 Query: 316 IAVY 319 + ++ Sbjct: 278 VTLW 281 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 60/297 (20%), Positives = 98/297 (32%), Gaps = 46/297 (15%) Query: 16 LRLRRAESTRRVLGLE--LNKDRDVERIHGGGINTLDI-EPVEGRYMLSGGSDGVIVLYD 72 L ++ T ++ +E +K D H G + +D P G + S DG ++++ Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 73 LENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG-MFTSSSFDKTLKVWDT-- 129 EN VH SV +VQW PH+ G + +S D + V + Sbjct: 84 EENGRWSQI-----------AVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKE 132 Query: 130 -NTLQTADVFNFEETVYSHHMSPV----------STKHCLVAVGTRGPKVQLC----DLK 174 T + V S +P + + G V++ D + Sbjct: 133 NGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQ 192 Query: 175 SGSCSHILQGHRQEILAVSWSPRY--DYILATASADSRVKLWDVRRASGCLITLDQHNGK 232 + L+GH + V+WSP LA+ S D +W G K Sbjct: 193 TYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEK 252 Query: 233 KSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCN 289 + ++ G L G DN++ LW N E G+V Sbjct: 253 FPDVL-----------WRASWSLSGNVLALSGGDNKVTLWK-ENLEGKWEPAGEVHQ 297 Score = 97.7 bits (241), Expect = 9e-21, Method: Composition-based stats. Identities = 38/256 (14%), Positives = 80/256 (31%), Gaps = 36/256 (14%) Query: 159 VAVGTRGPKVQLCDLK--SGSCSHILQGHRQEILAVSW-SPRYDYILATASADSRVKLWD 215 +A + +++ +++ + L GH + V W P++ ILA+ S D +V +W Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD--GLHLLTVGTDNRMRLWN 273 I + + H+ VN + + G LL +D ++ + Sbjct: 84 EENGRWSQI--------------AVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVE 129 Query: 274 SSNGENTLVNYGKVCNNSKKGLKFTVSC----------GCSSEFVFVPYGSTIAVY---- 319 T + + S +FV + + ++ Sbjct: 130 FKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNS 189 Query: 320 TVYSGEQITMLKGHYKTVDCCVFQSN---FQELYSGSRDCNILAWVPSLYEPVPDDDETT 376 + + L+GH V + L S S+D + W + Sbjct: 190 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLK 249 Query: 377 TKSQLNPAFEDAWSSS 392 + + + +WS S Sbjct: 250 EEKFPDVLWRASWSLS 265 Score = 76.5 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 35/226 (15%), Positives = 72/226 (31%), Gaps = 34/226 (15%) Query: 184 GHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTA 243 H + I Y LAT S+D +K+++V + LI T Sbjct: 7 AHNELIHDAVLDY-YGKRLATCSSDKTIKIFEVEGETHKLI--------------DTLTG 51 Query: 244 HNGKVNGLCFT--SDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSC 301 H G V + + G L + D ++ +W NG + + V + S +++ Sbjct: 52 HEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPH- 110 Query: 302 GCSSEFVFVPYGSTIAVYTVYSGEQIT--MLKGHYKTVDCCVFQS-------------NF 346 + ++V + ++ H V+ + Sbjct: 111 EYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKES 170 Query: 347 QELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSSS 392 ++ +G D + W + E+T + + + AWS + Sbjct: 171 RKFVTGGADNLVKIWKYNSDAQTYVL-ESTLEGHSDWVRDVAWSPT 215 Score = 33.4 bits (74), Expect = 0.20, Method: Composition-based stats. Identities = 8/53 (15%), Positives = 16/53 (30%) Query: 326 QITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTK 378 + + H + + V + L + S D I + D T + Sbjct: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHE 53 >2PM9-A nrPDB Length = 416 Score = 110 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 62/281 (22%), Positives = 99/281 (35%), Gaps = 39/281 (13%) Query: 63 GSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP-DVHRYSVETVQWYPHDTGMFTSSSFD 121 + I+ L+N S + Y T +A +I H SV+TV++ + S + Sbjct: 76 SHNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNN 135 Query: 122 KTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLV---------AVGTRGPKVQLCD 172 + +WD N T N+ MS V L A + D Sbjct: 136 GEIFIWDMNKC-TESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWD 194 Query: 173 LKSGSCSHIL------QGHRQEILAVSWSPRYDYILATASA---DSRVKLWDVRRASGCL 223 LK+ L G +Q++ V W P+ +ATA+ D + +WD+R A+ L Sbjct: 195 LKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPL 254 Query: 224 ITLDQHNGKKSQAVESANTAHNGKVNGLCF-TSDGLHLLTVGTDNRMRLWNSSNGENTLV 282 TL N H + L + D LL+ G DN + LWN + E Sbjct: 255 QTL--------------NQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQL-- 298 Query: 283 NYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYS 323 + K + F + + I V T+ + Sbjct: 299 --SQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQN 337 Score = 99.6 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 43/270 (15%), Positives = 87/270 (32%), Gaps = 31/270 (11%) Query: 39 ERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVH 98 H + T+ + + SGG++G I ++D+ + D Sbjct: 109 FSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDE- 167 Query: 99 RYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYS-------HHMSP 151 V ++ W +F S+ +WD + ++ P Sbjct: 168 ---VISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHP 224 Query: 152 VSTKHCLVAVGT-RGPKVQLCDLKS-GSCSHIL-QGHRQEILAVSWSPRYDYILATASAD 208 ++ A G+ P + + DL++ + L QGH++ IL++ W + +++L ++ D Sbjct: 225 KNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRD 284 Query: 209 SRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTV-GTDN 267 + V LW+ A + F + L DN Sbjct: 285 NTVLLWNPESAEQLSQFPARG----------------NWCFKTKFAPEAPDLFACASFDN 328 Query: 268 RMRLWNSSNGENTLVNYGKVCNNSKKGLKF 297 ++ + N NTL + F Sbjct: 329 KIEVQTLQNLTNTLDEQETETKQQESETDF 358 Score = 44.9 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 20/111 (18%), Positives = 42/111 (37%), Gaps = 15/111 (13%) Query: 27 VLGLEL--NKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTC 84 + L + + + H GI +LD + +LS G D ++L++ E++ + S + Sbjct: 244 IWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPA 303 Query: 85 KAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 + ++ P +F +SFD ++V L Sbjct: 304 RG-------------NWCFKTKFAPEAPDLFACASFDNKIEVQTLQNLTNT 341 Score = 30.7 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 22/163 (13%), Positives = 50/163 (30%), Gaps = 23/163 (14%) Query: 250 GLCFTSDG-LHLLTV----------GTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFT 298 ++ D L++ TD+ + LW+ ++ ++ L ++ Sbjct: 17 TFAWSHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLDWS 76 Query: 299 VSCGCSSEFVFVPYGSTIAVYTVYSGE----QITMLKGHYKTVDCCVFQSNFQ-ELYSGS 353 + + ++ +Y+ + H +V F + L SG Sbjct: 77 HN---NKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGG 133 Query: 354 RDCNILAWVPSLYEPVPDDDETTTK----SQLNPAFEDAWSSS 392 + I W + P + T S ++ AW+ S Sbjct: 134 NNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQS 176 >5M89-A nrPDB Length = 329 Score = 107 bits (267), Expect = 7e-24, Method: Composition-based stats. Identities = 47/242 (19%), Positives = 91/242 (37%), Gaps = 36/242 (14%) Query: 31 ELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSI 90 + ++ + H G + L + P GR + S G D V YDLE R + Sbjct: 118 DAGRESATFQTHAGPVTGLAVHP-GGRILASVGVDKSFVFYDLETGER-----------V 165 Query: 91 GRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMS 150 R + D ++ T ++P D +F + + + V+ T TL+ A+ F + + S Sbjct: 166 ARGYAD---AALTTCAFHP-DGNLFAAGTQTGHILVFHTTTLEQAESFPLGTPIQALAFS 221 Query: 151 PVSTKHCLVAVGTRGPKVQLCDLK-SGSCSHILQGHRQEILAVSWSPRYDYILATASADS 209 A G V + DL+ SG+ + + + E+L++SW Y+ Sbjct: 222 --ENGFWFAATGKGTSSVTIFDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATGGGTGV 279 Query: 210 RVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRM 269 V+++ + S+ V V G+ + + L+ V + + Sbjct: 280 TVQMY------------TKATKSWSEPVRLGM-----PVVGVKWGGEAKRLVVVSREGVV 322 Query: 270 RL 271 + Sbjct: 323 SV 324 Score = 51.5 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 39/225 (17%), Positives = 62/225 (27%), Gaps = 29/225 (12%) Query: 127 WDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHR 186 W T A + S + ++ AVG K+ + + + L Sbjct: 34 WATADDVAALQQVAYTDLNVTQASSLDLENECAAVGGLDGKLDIYSVVANKVERTLD-IG 92 Query: 187 QEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNG 246 + + A W + +A VK++D R S T H G Sbjct: 93 EPVTATEW---TGTKVVIGTAKGWVKVYDAGRESATFQT------------------HAG 131 Query: 247 KVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSE 306 V GL G L +VG D ++ GE Y + L + Sbjct: 132 PVTGLAVHPGGRILASVGVDKSFVFYDLETGERVARGY------ADAALTTCAFHPDGNL 185 Query: 307 FVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYS 351 F I V+ + EQ + F N + Sbjct: 186 FAAGTQTGHILVFHTTTLEQAESFPLGT-PIQALAFSENGFWFAA 229 Score = 39.5 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 22/185 (11%), Positives = 54/185 (29%), Gaps = 14/185 (7%) Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHN--GKVNGLCFTSDGLHLLTVGTDNRMRLW 272 D+ + LD S + V +T G ++ ++++ Sbjct: 60 DLENECAAVGGLDGKLDIYSVVANKVERTLDIGEPVTATEWT--GTKVVIGTAKGWVKVY 117 Query: 273 NSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKG 332 ++ + V + Y + +GE++ +G Sbjct: 118 DAG-------RESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVA--RG 168 Query: 333 HYKT-VDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSS 391 + + C F + +G++ +IL + + E T L + W + Sbjct: 169 YADAALTTCAFHPDGNLFAAGTQTGHILVFHTTTLEQAESFPLGTPIQALAFSENGFWFA 228 Query: 392 SDEEG 396 + +G Sbjct: 229 ATGKG 233 >3JRP-A nrPDB Length = 379 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 46/309 (14%), Positives = 98/309 (31%), Gaps = 48/309 (15%) Query: 33 NKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGR 92 + H I+ ++ G+ + + SD I ++++E + + T Sbjct: 1 GSMVVIANAHNELIHDAVLD-YYGKRLATCSSDKTIKIFEVEGETHKLIDTL-------- 51 Query: 93 DHPDVHRYSVETVQW-YPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSP 151 H V V W +P + S S+D + +W + + + V+S ++ Sbjct: 52 ---TGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQI--AVHAVHSASVNS 106 Query: 152 VSTK----HCLVAVGTRGPKVQLCDLKSGSCSH--ILQGHRQEILAVSWSP--------- 196 V L+ V + KV + + K + I+ H + + SW+P Sbjct: 107 VQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEH 166 Query: 197 ---RYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCF 253 + T AD+ VK+W ++ +ES H+ V + + Sbjct: 167 NGTKESRKFVTGGADNLVKIWKYNS------------DAQTYVLESTLEGHSDWVRDVAW 214 Query: 254 TSD---GLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFV 310 + +L +V D +W N + L + Sbjct: 215 SPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALS 274 Query: 311 PYGSTIAVY 319 + + ++ Sbjct: 275 GGDNKVTLW 283 Score = 98.8 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 60/297 (20%), Positives = 98/297 (32%), Gaps = 46/297 (15%) Query: 16 LRLRRAESTRRVLGLE--LNKDRDVERIHGGGINTLDI-EPVEGRYMLSGGSDGVIVLYD 72 L ++ T ++ +E +K D H G + +D P G + S DG ++++ Sbjct: 26 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 85 Query: 73 LENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG-MFTSSSFDKTLKVWDT-- 129 EN VH SV +VQW PH+ G + +S D + V + Sbjct: 86 EENGRWSQI-----------AVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKE 134 Query: 130 -NTLQTADVFNFEETVYSHHMSPV----------STKHCLVAVGTRGPKVQLC----DLK 174 T + V S +P + + G V++ D + Sbjct: 135 NGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQ 194 Query: 175 SGSCSHILQGHRQEILAVSWSPRY--DYILATASADSRVKLWDVRRASGCLITLDQHNGK 232 + L+GH + V+WSP LA+ S D +W G K Sbjct: 195 TYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEK 254 Query: 233 KSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCN 289 + ++ G L G DN++ LW N E G+V Sbjct: 255 FPDVL-----------WRASWSLSGNVLALSGGDNKVTLWK-ENLEGKWEPAGEVHQ 299 Score = 90.7 bits (223), Expect = 9e-19, Method: Composition-based stats. Identities = 38/256 (14%), Positives = 80/256 (31%), Gaps = 36/256 (14%) Query: 159 VAVGTRGPKVQLCDLK--SGSCSHILQGHRQEILAVSW-SPRYDYILATASADSRVKLWD 215 +A + +++ +++ + L GH + V W P++ ILA+ S D +V +W Sbjct: 26 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 85 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD--GLHLLTVGTDNRMRLWN 273 I + + H+ VN + + G LL +D ++ + Sbjct: 86 EENGRWSQI--------------AVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVE 131 Query: 274 SSNGENTLVNYGKVCNNSKKGLKFTVSC----------GCSSEFVFVPYGSTIAVY---- 319 T + + S +FV + + ++ Sbjct: 132 FKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNS 191 Query: 320 TVYSGEQITMLKGHYKTVDCCVFQSN---FQELYSGSRDCNILAWVPSLYEPVPDDDETT 376 + + L+GH V + L S S+D + W + Sbjct: 192 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLK 251 Query: 377 TKSQLNPAFEDAWSSS 392 + + + +WS S Sbjct: 252 EEKFPDVLWRASWSLS 267 Score = 71.9 bits (174), Expect = 5e-13, Method: Composition-based stats. Identities = 38/234 (16%), Positives = 75/234 (32%), Gaps = 34/234 (14%) Query: 176 GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQ 235 GS I H + I Y LAT S+D +K+++V + LI Sbjct: 1 GSMVVIANAHNELIHDAVLDY-YGKRLATCSSDKTIKIFEVEGETHKLI----------- 48 Query: 236 AVESANTAHNGKVNGLCFT--SDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKK 293 T H G V + + G L + D ++ +W NG + + V + S Sbjct: 49 ---DTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVN 105 Query: 294 GLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQIT--MLKGHYKTVDCCVFQS------- 344 +++ + ++V + ++ H V+ + Sbjct: 106 SVQWAPH-EYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDG 164 Query: 345 ------NFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSSS 392 ++ +G D + W + E+T + + + AWS + Sbjct: 165 EHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVL-ESTLEGHSDWVRDVAWSPT 217 >5MWJ-A nrPDB Length = 337 Score = 101 bits (252), Expect = 4e-22, Method: Composition-based stats. Identities = 45/321 (14%), Positives = 98/321 (30%), Gaps = 35/321 (10%) Query: 36 RDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP 95 R + ++ G + R++ +GG G + ++D+ + + + + Sbjct: 43 RQINTLNHGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNK--------SPVSQLDC 93 Query: 96 DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTK 155 + + + P + TL +WD + + + +S Sbjct: 94 LNRDNYIRSCKLLPDGCTLIVGGEA-STLSIWDLAAPTPRIKAELTSSAPACYALAISPD 152 Query: 156 HCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 + + + DL + + QGH + S L T D+ V+ WD Sbjct: 153 SKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTK-LWTGGLDNTVRSWD 211 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 +R L QH+ ++ L + G L + + + + + Sbjct: 212 LREGRQ----LQQHDF-------------TSQIFSLGYCPTGEWLAVGMESSNVEVLHVN 254 Query: 276 NGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYK 335 + + + LKF C FV + + + G I Sbjct: 255 KPDK---YQLHLHESCVLSLKFAY---CGKWFVSTGKDNLLNAWRTPYGASI-FQSKESS 307 Query: 336 TVDCCVFQSNFQELYSGSRDC 356 +V C + + + +GS D Sbjct: 308 SVLSCDISVDDKYIVTGSGDK 328 Score = 90.0 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 47/298 (15%), Positives = 90/298 (30%), Gaps = 33/298 (11%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN---TLQTADVFNFEETVYSHHMSPVST 154 H V V ++T +KVWD + + + Sbjct: 50 HGEVVCAVTISNPTRHVYTGGK--GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLP 107 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSC--SHILQGHRQEILAVSWSPRYDYILATASADSRVK 212 C + VG + + DL + + L A++ SP + + +D + Sbjct: 108 DGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPD-SKVCFSCCSDGNIA 166 Query: 213 LWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLW 272 +WD+ Q + H + + ++DG L T G DN +R W Sbjct: 167 VWDLHN----------------QTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSW 210 Query: 273 NSSNGENTLVNYGKVCNNSKKGLKFTVS-CGCSSEFVFVPYGSTIAVYTVYSGEQITMLK 331 + G + F++ C S + V V ++ L Sbjct: 211 DLREGRQLQ-------QHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDK-YQLH 262 Query: 332 GHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAW 389 H V F + S +D + AW + E+++ + + +D + Sbjct: 263 LHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKY 320 Score = 54.2 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 28/179 (15%), Positives = 54/179 (30%), Gaps = 32/179 (17%) Query: 22 ESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSS---- 77 + V L + H G + +DI +G + +GG D + +DL Sbjct: 162 DGNIAVWDLHNQTLVRQFQGHTDGASCIDIS-NDGTKLWTGGLDNTVRSWDLREGRQLQQ 220 Query: 78 -----------------------RQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGM 114 S V + +H V ++++ + Sbjct: 221 HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKF-AYCGKW 279 Query: 115 FTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDL 173 F S+ D L W T A +F +E+ +S + G+ K + ++ Sbjct: 280 FVSTGKDNLLNAW--RTPYGASIFQSKESSSVLSC-DISVDDKYIVTGSGDKKATVYEV 335 >3ODT-A nrPDB Length = 313 Score = 99 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 45/255 (17%), Positives = 85/255 (33%), Gaps = 33/255 (12%) Query: 115 FTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRG--PKVQLCD 172 S S D T+++W + Q + + + + S K L+ G V L Sbjct: 32 VASVSRDGTVRLWSKD-DQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDTMINGVPLFA 90 Query: 173 LKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGK 232 + L GH+ + ++S+ D ++ + S D K+W Sbjct: 91 TSGEDPLYTLIGHQGNVCSLSF---QDGVVISGSWDKTAKVW------------------ 129 Query: 233 KSQAVESANTAHNGKVNGLCFTS-DGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNS 291 K ++ AHN V S LT D ++LW + + + + N+ Sbjct: 130 KEGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLW---QNDKVIKTFSGIHNDV 186 Query: 292 KKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYS 351 + L + F+ I + +++G+ + +GH V C N + S Sbjct: 187 VRHL----AVVDDGHFISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD-IVS 241 Query: 352 GSRDCNILAWVPSLY 366 D + W Sbjct: 242 CGEDRTVRIWSKENG 256 Score = 95.8 bits (236), Expect = 3e-20, Method: Composition-based stats. Identities = 45/319 (14%), Positives = 104/319 (32%), Gaps = 46/319 (14%) Query: 57 RYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFT 116 + S DG + L+ S+ + V + + + +V + + Sbjct: 30 SKVASVSRDGTVRLW-----SKDDQWLGTVVYTG--------QGFLNSVCYDSEKELLLF 76 Query: 117 SSSFDKT--LKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLK 174 + ++ T+ + ++ +S + +V G+ ++ K Sbjct: 77 GGKDTMINGVPLFATSGEDPLYTLIGHQ----GNVCSLSFQDGVVISGSWDKTAKVW--K 130 Query: 175 SGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKS 234 GS + LQ H + + TASAD +KLW + Sbjct: 131 EGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLW-----------------QND 173 Query: 235 QAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKG 294 + +++ + HN V L DG H ++ D ++L + G+ G + Sbjct: 174 KVIKTFSGIHNDVVRHLAVVDDG-HFISCSNDGLIKLVDMHTGDVLRTYEGH------ES 226 Query: 295 LKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSR 354 + + + + V T+ +++ +G ++ ++ SN + GS Sbjct: 227 FVYCIKLLPNGDIVSCGEDRTVRIWSKENGSLKQVITLPAISIWSVDCMSNGDIIV-GSS 285 Query: 355 DCNILAWVPSLYEPVPDDD 373 D + + +D+ Sbjct: 286 DNLVRIFSQEKSRWASEDE 304 Score = 75.7 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 32/204 (15%), Positives = 68/204 (33%), Gaps = 25/204 (12%) Query: 19 RRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSR 78 + T +V + + H + + L+ +D I L+ + Sbjct: 120 GSWDKTAKVW--KEGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLWQNDK--- 174 Query: 79 QSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF 138 + + +H V + D G F S S D +K+ D +T + Sbjct: 175 -----------VIKTFSGIHNDVVRHLAVV--DDGHFISCSNDGLIKLVDMHTGDVLRTY 221 Query: 139 NFEET-VYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPR 197 E+ VY + P + V++ ++GS ++ I +V Sbjct: 222 EGHESFVYCIKLLPNGD----IVSCGEDRTVRIWSKENGSLKQVITLPAISIWSVDCMSN 277 Query: 198 YDYILATASADSRVKLWDVRRASG 221 D I+ S+D+ V+++ ++ Sbjct: 278 GDIIV--GSSDNLVRIFSQEKSRW 299 >4BZK-B nrPDB Length = 297 Score = 99.6 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 44/286 (15%), Positives = 92/286 (32%), Gaps = 47/286 (16%) Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQW-YPHDTGM 114 G+ + + SD I ++++E + + T H V V W +P + Sbjct: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTL-----------TGHEGPVWRVDWAHPKFGTI 69 Query: 115 FTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTK----HCLVAVGTRGPKVQL 170 S S+D + +W + + + V+S ++ V L+ V + KV + Sbjct: 70 LASCSYDGKVLIWKEENGRWSQI--AVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 Query: 171 CDLKSGSCSH--ILQGHRQEILAVSWSP------------RYDYILATASADSRVKLWDV 216 + K + I+ H + + SW+P + T AD+ VK+W Sbjct: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD---GLHLLTVGTDNRMRLWN 273 ++ +ES H+ V + ++ +L +V D +W Sbjct: 188 NS------------DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 Query: 274 SSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVY 319 N + L + + + ++ Sbjct: 236 QDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 95.8 bits (236), Expect = 3e-20, Method: Composition-based stats. Identities = 60/297 (20%), Positives = 98/297 (32%), Gaps = 46/297 (15%) Query: 16 LRLRRAESTRRVLGLE--LNKDRDVERIHGGGINTLDI-EPVEGRYMLSGGSDGVIVLYD 72 L ++ T ++ +E +K D H G + +D P G + S DG ++++ Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 73 LENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG-MFTSSSFDKTLKVWDT-- 129 EN VH SV +VQW PH+ G + +S D + V + Sbjct: 84 EENGRWSQI-----------AVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKE 132 Query: 130 -NTLQTADVFNFEETVYSHHMSPV----------STKHCLVAVGTRGPKVQLC----DLK 174 T + V S +P + + G V++ D + Sbjct: 133 NGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQ 192 Query: 175 SGSCSHILQGHRQEILAVSWSPRY--DYILATASADSRVKLWDVRRASGCLITLDQHNGK 232 + L+GH + V+WSP LA+ S D +W G K Sbjct: 193 TYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEK 252 Query: 233 KSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCN 289 + ++ G L G DN++ LW N E G+V Sbjct: 253 FPDVL-----------WRASWSLSGNVLALSGGDNKVTLWK-ENLEGKWEPAGEVHQ 297 Score = 88.1 bits (216), Expect = 6e-18, Method: Composition-based stats. Identities = 38/256 (14%), Positives = 80/256 (31%), Gaps = 36/256 (14%) Query: 159 VAVGTRGPKVQLCDLK--SGSCSHILQGHRQEILAVSW-SPRYDYILATASADSRVKLWD 215 +A + +++ +++ + L GH + V W P++ ILA+ S D +V +W Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD--GLHLLTVGTDNRMRLWN 273 I + + H+ VN + + G LL +D ++ + Sbjct: 84 EENGRWSQI--------------AVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVE 129 Query: 274 SSNGENTLVNYGKVCNNSKKGLKFTVSC----------GCSSEFVFVPYGSTIAVY---- 319 T + + S +FV + + ++ Sbjct: 130 FKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNS 189 Query: 320 TVYSGEQITMLKGHYKTVDCCVFQSN---FQELYSGSRDCNILAWVPSLYEPVPDDDETT 376 + + L+GH V + L S S+D + W + Sbjct: 190 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLK 249 Query: 377 TKSQLNPAFEDAWSSS 392 + + + +WS S Sbjct: 250 EEKFPDVLWRASWSLS 265 Score = 68.4 bits (165), Expect = 5e-12, Method: Composition-based stats. Identities = 35/226 (15%), Positives = 72/226 (31%), Gaps = 34/226 (15%) Query: 184 GHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTA 243 H + I Y LAT S+D +K+++V + LI T Sbjct: 7 AHNELIHDAVLDY-YGKRLATCSSDKTIKIFEVEGETHKLI--------------DTLTG 51 Query: 244 HNGKVNGLCFT--SDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSC 301 H G V + + G L + D ++ +W NG + + V + S +++ Sbjct: 52 HEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPH- 110 Query: 302 GCSSEFVFVPYGSTIAVYTVYSGEQIT--MLKGHYKTVDCCVFQS-------------NF 346 + ++V + ++ H V+ + Sbjct: 111 EYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKES 170 Query: 347 QELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSSS 392 ++ +G D + W + E+T + + + AWS + Sbjct: 171 RKFVTGGADNLVKIWKYNSDAQTYVL-ESTLEGHSDWVRDVAWSPT 215 Score = 31.0 bits (68), Expect = 0.79, Method: Composition-based stats. Identities = 8/53 (15%), Positives = 16/53 (30%) Query: 326 QITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTK 378 + + H + + V + L + S D I + D T + Sbjct: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHE 53 >2AQ5-A nrPDB Length = 402 Score = 99.6 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 39/247 (15%), Positives = 80/247 (32%), Gaps = 29/247 (11%) Query: 31 ELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSI 90 ++K+ + H + + P + SG D ++++++ + + Sbjct: 69 RVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITL- 127 Query: 91 GRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMS 150 + H V V W+P + S+ D + VWD T + + + Sbjct: 128 -----EGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSV 182 Query: 151 PVSTKHCLVAVGTRGPKVQLCDLKSGSCSHIL-QGH--RQEILAVSWSPRYDYILATA-- 205 S L+ R +V++ + + G+ + H + + AV S IL T Sbjct: 183 DWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVS--EGKILTTGFS 240 Query: 206 -SADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVG 264 ++ +V LWD + L + F D + G Sbjct: 241 RMSERQVALWDTKHLEEPLSLQELDTSSGVLLPF--------------FDPDTNIVYLCG 286 Query: 265 T-DNRMR 270 D+ +R Sbjct: 287 KGDSSIR 293 Score = 88.8 bits (218), Expect = 3e-18, Method: Composition-based stats. Identities = 37/243 (15%), Positives = 74/243 (30%), Gaps = 26/243 (10%) Query: 137 VFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSG-------SCSHILQGHRQEI 189 T ++ ++A G+ V + ++ G L+GH + + Sbjct: 75 PLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRV 134 Query: 190 LAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVN 249 V+W P +L +A D+ + +WDV G + + H + Sbjct: 135 GIVAWHPTAQNVLLSAGCDNVILVWDV--------------GTGAAVLTLGPDVHPDTIY 180 Query: 250 GLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVF 309 + ++ DG + T D R+R+ G F + Sbjct: 181 SVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSEGKILTTGFS 240 Query: 310 VPYGSTIAVYTVYSGEQ---ITMLKGHYKTVDCCVFQSNFQELY-SGSRDCNILAWVPSL 365 +A++ E+ + L V F + +Y G D +I + + Sbjct: 241 RMSERQVALWDTKHLEEPLSLQELDTSSG-VLLPFFDPDTNIVYLCGKGDSSIRYFEITS 299 Query: 366 YEP 368 P Sbjct: 300 EAP 302 Score = 75.3 bits (183), Expect = 5e-14, Method: Composition-based stats. Identities = 42/236 (17%), Positives = 81/236 (34%), Gaps = 32/236 (13%) Query: 16 LRLRRAESTRRVLG-------LELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVI 68 + + T V L L + H + + P +LS G D VI Sbjct: 97 IASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVI 156 Query: 69 VLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWD 128 +++D+ ++ PDVH ++ +V W D + +S DK ++V + Sbjct: 157 LVWDVGTG-----------AAVLTLGPDVHPDTIYSVDWS-RDGALICTSCRDKRVRVIE 204 Query: 129 TNTLQTA----DVFNFEETVYSHHMSPVSTKHCLVAVG---TRGPKVQLCDLKSGSCSHI 181 V++ +S + ++ G +V L D K Sbjct: 205 PRKGTVVAEKDRPHEGTRPVHAVFVS----EGKILTTGFSRMSERQVALWDTKHLEEPLS 260 Query: 182 LQG--HRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQ 235 LQ +L + P + + DS ++ +++ + L L + K+SQ Sbjct: 261 LQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMFSSKESQ 316 Score = 75.0 bits (182), Expect = 5e-14, Method: Composition-based stats. Identities = 22/162 (13%), Positives = 46/162 (28%), Gaps = 6/162 (3%) Query: 218 RASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS-DGLHLLTVGTDNRMRLWNSSN 276 G + L + H V + + + + + D + +W + Sbjct: 54 SGGGAFLVLPLGKTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPD 113 Query: 277 GENTLVNYGKVC--NNSKKGLKFTVSCGCSSEFV-FVPYGSTIAVYTVYSGEQITMLKG- 332 G L V K + + + + I V+ V +G + L Sbjct: 114 GGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPD 173 Query: 333 -HYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDD 373 H T+ + + + + RD + P V + D Sbjct: 174 VHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKD 215 >3EI3-B nrPDB Length = 383 Score = 99.2 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 66/336 (19%), Positives = 113/336 (33%), Gaps = 47/336 (13%) Query: 46 INTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETV 105 + +L+ P + G G I+L+D + ++ S+ ++ + Sbjct: 76 VTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPG-----------DAITGM 124 Query: 106 QWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF-NFEETVYSHHMSPVSTKHCLVAVGTR 164 ++ +T SS + D + VF + Y + VS ++A G Sbjct: 125 KFNQFNTNQLFVSSIRGATTLRDF-SGSVIQVFAKTDSWDYWYCCVDVSVSRQMLATGDS 183 Query: 165 GPKVQLCDLKSGSCSHILQG--HRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGC 222 ++ L I + H+ ++ ++PR D+++AT+S D+ VKLWD+R Sbjct: 184 TGRLL---LLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNI--- 237 Query: 223 LITLDQHNGKKSQAVESANTAHNGKVNGLCFTS-DGLHLLTVGTDNRMRLWNSSNGENTL 281 K + A H VN F D LLT N +R+++S + Sbjct: 238 ----------KDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYDWSKPD 287 Query: 282 VNYGKVC--NNSKKGLKFTVSCGCSSEFVFVPY---------GSTIAVYTVYSGEQITML 330 +K T V Y TI +Y SG + L Sbjct: 288 QIIIHPHRQFQHLTPIKAT-WHPMYDLIVAGRYPDDQLLLNDKRTIDIYDANSGGLVHQL 346 Query: 331 K--GHYKTVDCCVFQSNFQELYSGSRDCNILAWVPS 364 + + F L SG NIL W Sbjct: 347 RDPNAAGIISLNKFSPTGDVLASG-MGFNILIWNRE 381 Score = 70.7 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 32/196 (16%), Positives = 66/196 (33%), Gaps = 27/196 (13%) Query: 39 ERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVH 98 E++H + + P M + D + L+DL N ++ Y H Sbjct: 200 EKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYI----------AEMPH 249 Query: 99 RYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKH-- 156 V + P D+ ++ ++V+ + D H++P+ Sbjct: 250 EKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKATWHP 309 Query: 157 --CLVAVG---------TRGPKVQLCDLKSGSCSHILQ-GHRQEILAV-SWSPRYDYILA 203 L+ G + + D SG H L+ + I+++ +SP D +LA Sbjct: 310 MYDLIVAGRYPDDQLLLNDKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSPTGD-VLA 368 Query: 204 TASADSRVKLWDVRRA 219 + + +W+ Sbjct: 369 SG-MGFNILIWNREDT 383 Score = 49.1 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 31/232 (13%), Positives = 63/232 (27%), Gaps = 35/232 (15%) Query: 173 LKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGK 232 LKS + + ++ W P + +A S + LWD + G Sbjct: 60 LKSYKLHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGD 119 Query: 233 KSQAVESANTAHNG-KVNGLC-------FTSDGLHLL--TVGTDNRMRLWNSSNGENTL- 281 ++ N V+ + F+ + + T D + S L Sbjct: 120 AITGMKFNQFNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQMLA 179 Query: 282 -----------------VNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSG 324 + K+ +F C +T+ ++ + + Sbjct: 180 TGDSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDW--LMATSSVDATVKLWDLRNI 237 Query: 325 EQITMLKG---HYKTVDCCVFQS-NFQELYSGSRDCNILAWVPSLYEPVPDD 372 + H K V+ F + +L + + I + S PD Sbjct: 238 KDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRVY-SSYDWSKPDQ 288 >5BJS-A nrPDB Length = 605 Score = 98.8 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 51/339 (15%), Positives = 103/339 (30%), Gaps = 72/339 (21%) Query: 71 YDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG----MFTSSSFDKTL-- 124 ++L + V++YP+ +F ++S + Sbjct: 49 WELPRLRTSFIFQDDYKYLGDDGSVSQDLAEFFDVKFYPYSPPGAPPVFAATSKKHAVIC 108 Query: 125 ---KVWDTNTLQTADVFNFEETVYSHHMSPVS-----TKHCLVAVGTRGPKVQLCDLKSG 176 + D + + + + + T L+ + V++ ++ G Sbjct: 109 RLTQTTDKDANPCEIIQLIRDDGNEANCASCWSKDPITDQPLLCIAGNEGNVKVYNVTEG 168 Query: 177 SCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQA 236 L GH I ++ SP YI+A+AS D+ +++W +L + K+ Sbjct: 169 KLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIW----------SLAPEHEKQPCV 218 Query: 237 VESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLK 296 H+ + + F +G ++L+ G D + LW N + Sbjct: 219 CILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEI------------ 266 Query: 297 FTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYS-GSRD 355 ++ P+ S+ + H VDC F + S + Sbjct: 267 --------PIVIYYPHFSSSEI--------------HNNLVDCVAFY--GDLILSRACHE 302 Query: 356 CNILAWVPSLYE-----------PVPDDDETTTKSQLNP 383 I+ W + P P D T+S P Sbjct: 303 DTIVLWRIEGFSSDDPIPGPLDAPTPTDMTKQTRSYFTP 341 Score = 66.5 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 33/196 (16%), Positives = 58/196 (29%), Gaps = 41/196 (20%) Query: 26 RVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCK 85 +V + K HGGGIN L P + S D I ++ L + C Sbjct: 161 KVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVC- 219 Query: 86 AVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVY 145 + H Y + +V ++ + S+ D+ + +W + Y Sbjct: 220 ------ILGGEGHSYDLLSVAFH-DNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYY 272 Query: 146 SHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATA 205 H S + H + V++ D IL+ A Sbjct: 273 PHFSSS-------------------------------EIHNNLVDCVAF--YGDLILSRA 299 Query: 206 SADSRVKLWDVRRASG 221 + + LW + S Sbjct: 300 CHEDTIVLWRIEGFSS 315 Score = 51.1 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 22/118 (18%), Positives = 44/118 (37%), Gaps = 9/118 (7%) Query: 16 LRLRRAESTRRVLGL----ELNKDRDV--ERIHGGGINTLDIEPVEGRYMLSGGSDGVIV 69 + ++T R+ L E + H + ++ GRY+LS G D VI Sbjct: 194 IASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFH-DNGRYVLSAGHDQVIN 252 Query: 70 LYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVW 127 L+ L + + ++H V+ V +Y + + + + T+ +W Sbjct: 253 LWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFY--GDLILSRACHEDTIVLW 308 >5K0Y-T nrPDB Length = 329 Score = 98.8 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 54/341 (15%), Positives = 106/341 (31%), Gaps = 56/341 (16%) Query: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 + H I + EG + + D ++ ++ N R Y H Sbjct: 7 QGHERSITQIKYN-REGDLLFTVAKDPIVNVWYSVNGERLGTYMG-------------HT 52 Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETV------YSHHMSPVS 153 +V V DT + S D + ++WD T + + V + ++ S Sbjct: 53 GAVWCVDAD-WDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFS 111 Query: 154 TKHCLVAVGTRGPKVQLCDLK------SGSCSHILQGHRQEILAVSWSPRYDYILATASA 207 T + V DL+ + + + +I + W P + I+A Sbjct: 112 TDKQM----GYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIA---- 163 Query: 208 DSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDN 267 G KS V H+ ++N + + + +T DN Sbjct: 164 -------------GHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSREMTMFVTASKDN 210 Query: 268 RMRLWNSSNGENTLVNYGK----VCNNSKKGLKFTVSCGCSSEFVFVPY---GST-IAVY 319 +L++S+ E+ + + S V G + V G + Sbjct: 211 TAKLFDSTTLEHQKTFRTEPPRELAALSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFF 270 Query: 320 TVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA 360 + E+ +KGH+ ++ F + + SG D + Sbjct: 271 HLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311 Score = 83.0 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 41/299 (13%), Positives = 86/299 (28%), Gaps = 51/299 (17%) Query: 14 DPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDL 73 D L + V + H G + +D + + +++L+G +D L+D Sbjct: 23 DLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDAD-WDTKHVLTGSADNSCRLWDC 81 Query: 74 ENSS----------------------------RQSYYTCKAVCSIGRDHPDVHR------ 99 E +Q Y C RD + Sbjct: 82 ETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMK 141 Query: 100 -----YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQT-ADVFNFEETVYSHHMSPVS 153 + + W P + L + + + +V + + S Sbjct: 142 IPCNDSKITSAVWGPLGEC-IIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQL---S 197 Query: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKL 213 + + ++ +L D + + LA + SP Y++++ ++ Sbjct: 198 REMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRELA-ALSPNYEHVVVGGGQEAM--- 253 Query: 214 WDVRRASGCLITLDQHNG-KKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL 271 DV S + + + H G +N + F DG + G D +R+ Sbjct: 254 -DVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311 Score = 69.6 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 40/265 (15%), Positives = 75/265 (28%), Gaps = 66/265 (24%) Query: 181 ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA 240 +LQGH + I + ++ D +L T + D V +W L T Sbjct: 5 LLQGHERSITQIKYNREGD-LLFTVAKDPIVNVW-YSVNGERLGT--------------- 47 Query: 241 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVC------NNSKKG 294 H G V + D H+LT DN RLW+ G+ + + Sbjct: 48 YMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNI 107 Query: 295 LKFT-----------------------------------------VSCGCSSEFVFVPYG 313 + F+ V + Sbjct: 108 IMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHES 167 Query: 314 STIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSL--YEPVPD 371 + Y+ SGE + +K H + ++ + S+D + + ++ Sbjct: 168 GELNQYSAKSGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFR 227 Query: 372 DDETTTKSQLNPAFEDAWSSSDEEG 396 + + L+P +E +E Sbjct: 228 TEPPRELAALSPNYEHVVVGGGQEA 252 >5WYJ-BE nrPDB Length = 939 Score = 96.1 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 43/316 (13%), Positives = 99/316 (31%), Gaps = 46/316 (14%) Query: 41 IHGGGINTLDIEPVEGRYMLSGGSDGVIVLY------DLENSSRQSYYTCK------AVC 88 H + + + +MLS D L+ D ++ K Sbjct: 348 GHSQPPSYIAFADSQSHFMLSASKDRS--LWSFSLRKDAQSQEMSQRLHKKQDGGRVGGS 405 Query: 89 SIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHH 148 +I P++ ++E + + T+ +K + WD + Sbjct: 406 TIKSKFPEIVALAIENARIG-EWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVK 464 Query: 149 MSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASAD 208 +S +G+ + + +++SG + H++ + +S ++ + D Sbjct: 465 SVAMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMV-SCGLD 523 Query: 209 SRVKLWD-------------------VRRASGCLITLDQHN------GKKSQAVESANTA 243 V +D V S L L + +Q V Sbjct: 524 GIVGFYDFNKSTLLGKLKLDAPITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWG 583 Query: 244 HNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGC 303 H+ ++ F+ +G +++ D+ +R W+ G G + +N +KF+ + Sbjct: 584 HSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCID---GIIVDNVATNVKFSPNGDL 640 Query: 304 SSEFVFVPYGSTIAVY 319 G+ I ++ Sbjct: 641 --LATTHVTGNGICIW 654 Score = 86.5 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 45/337 (13%), Positives = 98/337 (29%), Gaps = 29/337 (8%) Query: 44 GGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVE 103 GG+ + +++ G D + Y + S Q H Sbjct: 296 GGVTQATFLNGQP-IIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPS 354 Query: 104 TVQWYPHDTGMFTSSSFDKTLKVW------DTNTLQTADVFNFEETVYSHHMSPVSTKHC 157 + + + S+S D++ +W D + + + + ++ S + +K Sbjct: 355 YIAFADSQSHFMLSASKDRS--LWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFP 412 Query: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSW---SPRYDYILATASADSRVKLW 214 + + + + + G +I+ H+ E A +W + R + D VK Sbjct: 413 EIVA------LAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSV 466 Query: 215 DVRRASGCLITLDQHN-----GKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRM 269 + + + +S + H V G+ +++ G D + Sbjct: 467 AMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIV 526 Query: 270 RLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITM 329 ++ + + V S F +I V + + Sbjct: 527 GFYDFNKSTLLGKL------KLDAPITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQ 580 Query: 330 LKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLY 366 L GH + F + + S S D I W Sbjct: 581 LWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTG 617 Score = 72.6 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 33/247 (13%), Positives = 86/247 (34%), Gaps = 23/247 (9%) Query: 17 RLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENS 76 + + + + ++ R ++H + + ++ + R M+S G DG++ YD S Sbjct: 476 FIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGM-NRKMVSCGLDGIVGFYDFNKS 534 Query: 77 SRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTAD 136 + + + ++ + +F + D ++ V D T + Sbjct: 535 TLLGKLKLD--------------APITAMVYH-RSSDLFALALDDLSIVVIDAVTQRVVR 579 Query: 137 VFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEI-LAVSWS 195 + S + + + ++ DL +G C + + V +S Sbjct: 580 QLWGHSNRITAF--DFSPEGRWIVSASLDSTIRTWDLPTGGCIDGI--IVDNVATNVKFS 635 Query: 196 PRYDYILATASADSRVKLWDVRRASGCLI--TLDQHNGKKSQAVESANTAHNGKVNGLCF 253 P D + T + + +W R + T+D+ + ++ ++ ++G Sbjct: 636 PNGDLLATTHVTGNGICIWTNRAQFKTVSTRTIDESEFARMALPSTSVRGNDSMLSGALE 695 Query: 254 TSDGLHL 260 ++ G L Sbjct: 696 SNGGEDL 702 >5FA5-B nrPDB Length = 367 Score = 96.1 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 54/256 (21%), Positives = 85/256 (33%), Gaps = 37/256 (14%) Query: 20 RAESTRRVLGLELNKDRDVERI----HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 + L+ N+ V + H ++T+ + G +SG D I ++DL Sbjct: 123 SDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVL-SSGTQAVSGSKDICIKVWDLA- 180 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 + H V V PH +F S S D + +WDT + A Sbjct: 181 ------------QQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPA 228 Query: 136 DVFNFEETVYSHHMSPVSTKHCLVAV-GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSW 194 Y + V V G V L D KS SC H Q + + + Sbjct: 229 SQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVF 288 Query: 195 SPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFT 254 SP LA+ S D + + D S + + AH V ++ Sbjct: 289 SPHSVPFLASLSEDCSLAVLD-----------------SSLSELFRSQAHRDFVRDATWS 331 Query: 255 S-DGLHLLTVGTDNRM 269 + L TVG D+++ Sbjct: 332 PLNHSLLTTVGWDHQV 347 Score = 85.4 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 36/197 (18%), Positives = 62/197 (31%), Gaps = 15/197 (7%) Query: 19 RRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSR 78 + +V L R H + + P + LS D I+L+D Sbjct: 168 GSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKP 227 Query: 79 QSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA-DV 137 S C A + ++ W+P + +F + T+ + DT + Sbjct: 228 ASQIGCSAPGYLP-----------TSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSS 276 Query: 138 FNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPR 197 + V SP S +A + + + D Q HR + +WSP Sbjct: 277 AVHSQCVTGLVFSPHSV--PFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSPL 333 Query: 198 YDYILATASADSRVKLW 214 +L T D +V Sbjct: 334 NHSLLTTVGWDHQVVHH 350 Score = 80.3 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 41/257 (15%), Positives = 81/257 (31%), Gaps = 24/257 (9%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQT--ADVFNFEETVYSHHMSPVSTK 155 V + W + S S +++W+ + +T F E V + Sbjct: 104 TEAGVADLTWVGERGILVASDS--GAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSS 161 Query: 156 HCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 G++ +++ DL + H ++ V+ SP D + + S D+R+ LWD Sbjct: 162 GTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 221 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDN-RMRLWNS 274 R A + +A L + + G +N + L ++ Sbjct: 222 TR--------------CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDT 267 Query: 275 SNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHY 334 + L + V + GL F+ + ++AV E + H Sbjct: 268 KSTSCVLSSA--VHSQCVTGLVFSPHS--VPFLASLSEDCSLAVLDSSLSELFRS-QAHR 322 Query: 335 KTVDCCVFQSNFQELYS 351 V + L + Sbjct: 323 DFVRDATWSPLNHSLLT 339 Score = 55.7 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 30/159 (18%), Positives = 50/159 (31%), Gaps = 10/159 (6%) Query: 245 NGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS-CGC 303 V L + + +L + LW E +V+ K C + TVS Sbjct: 105 EAGVADLTWVGE-RGILVASDSGAVELWELDENETLIVS--KFCKYEHDDIVSTVSVLSS 161 Query: 304 SSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSN-FQELYSGSRDCNILAWV 362 ++ V I V+ + ++ + H V C + S S D IL W Sbjct: 162 GTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 221 Query: 363 PSLYEPVPDDDETT-----TKSQLNPAFEDAWSSSDEEG 396 +P + T +P + + DE G Sbjct: 222 TRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENG 260 Score = 48.8 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 14/109 (12%), Positives = 28/109 (25%), Gaps = 14/109 (12%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 T ++ + +H + L P ++ S D + + D Sbjct: 253 FVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD--- 309 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTL 124 HR V W P + + T+ +D + Sbjct: 310 -----------SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 34.1 bits (76), Expect = 0.12, Method: Composition-based stats. Identities = 20/126 (15%), Positives = 37/126 (29%), Gaps = 10/126 (7%) Query: 245 NGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNG---ENTLVNYGKVCNNSKKGLKFTVSC 301 ++ + SDG LL + R W S + C+ + Sbjct: 53 ERQLEAARYRSDGALLLGASS-LSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADL 111 Query: 302 GC--SSEFVFVPYGSTIAVYTVYSGEQITMLK----GHYKTVDCCVFQSNFQELYSGSRD 355 + + ++ + E + + K H V S+ + SGS+D Sbjct: 112 TWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKD 171 Query: 356 CNILAW 361 I W Sbjct: 172 ICIKVW 177 >5A9Q-7 nrPDB Length = 360 Score = 95.4 bits (235), Expect = 4e-20, Method: Composition-based stats. Identities = 52/327 (15%), Positives = 115/327 (35%), Gaps = 36/327 (11%) Query: 16 LRLRRAESTRRVLGLELNKDRDVE---RIHGGGINTLDI-EPVEGRYMLSGGSDGVIVLY 71 + ++ + +V + D + H G + + P G+ + S D ++ Sbjct: 27 MATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVW 86 Query: 72 DLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGM-FTSSSFDKTLKVW--- 127 + ++ D SV V++ P G+ + S D ++++ Sbjct: 87 EEIVGESNDKLRGQSHWVKRTTLVDSRT-SVTDVKFAPKHMGLMLATCSADGIVRIYEAP 145 Query: 128 ---DTNTLQTADVFNFEETVYSHHMSPVSTK--HCLVAVGTRGPK------VQLCDLKSG 176 + + + + + +P S++ ++AVG+ VQ+ + Sbjct: 146 DVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNEN 205 Query: 177 SCSH----ILQGHRQEILAVSWSPRYD---YILATASADSRVKLWDVRRASGCLITLDQH 229 + + L + ++++P +ILA A+ D V+++ ++ L + Sbjct: 206 TRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD--VRIFTLKPVRKELTSSGGP 263 Query: 230 NGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCN 289 + V + HN +V + + G L + G D +RLW ++ +N C Sbjct: 264 TKFEIHIVAQFD-NHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDN------WKCT 316 Query: 290 NSKKGLKFTVSCGCSSEFVFVPYGSTI 316 KG V+ GSTI Sbjct: 317 GILKGNGSPVNGSSQQGTSNPSLGSTI 343 Score = 74.6 bits (181), Expect = 7e-14, Method: Composition-based stats. Identities = 51/360 (14%), Positives = 104/360 (28%), Gaps = 85/360 (23%) Query: 36 RDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP 95 R + H I+ + + GR M + SD + ++D S + C A Sbjct: 5 RSIAADHKDLIHDVSFD-FHGRRMATCSSDQSVKVWD---KSESGDWHCTAS-------W 53 Query: 96 DVHRYSVETVQW-YPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVST 154 H SV V W +P + S SFD+T VW+ ++ D + Sbjct: 54 KTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSH----------- 102 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRY-DYILATASADSRVKL 213 + L D ++ + V ++P++ +LAT SAD V++ Sbjct: 103 ---------WVKRTTLVDSRTS------------VTDVKFAPKHMGLMLATCSADGIVRI 141 Query: 214 WDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS-----DGLHLLTVGTDN- 267 ++ QH + + + + + D+ Sbjct: 142 YEAPDVMNLSQWSLQHEISCKLS-----------CSCISWNPSSSRAHSPMIAVGSDDSS 190 Query: 268 -------RMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYT 320 ++ +N + + + + F + G S + + + ++T Sbjct: 191 PNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIAT-KDVRIFT 249 Query: 321 VYSGE---------------QITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSL 365 + + H V + L S D + W + Sbjct: 250 LKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANY 309 Score = 34.1 bits (76), Expect = 0.095, Method: Composition-based stats. Identities = 15/82 (18%), Positives = 21/82 (25%), Gaps = 6/82 (7%) Query: 292 KKGLKFTVSCGCSSE-FVFVPYGSTIAVYT---VYSGEQITMLKGHYKTVDCCVF-QSN- 345 K L VS ++ V+ K H +V + Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70 Query: 346 FQELYSGSRDCNILAWVPSLYE 367 Q L S S D W + E Sbjct: 71 GQVLASCSFDRTAAVWEEIVGE 92 >3BG0-A nrPDB Length = 316 Score = 93.8 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 51/288 (17%), Positives = 97/288 (33%), Gaps = 51/288 (17%) Query: 16 LRLRRAESTRRVLGLELNKDRDVE--RIHGGGINTLDI-EPVEGRYMLSGGSDGVIVLYD 72 L ++ + ++ + + R H G + + P+ G + S D ++++ Sbjct: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 87 Query: 73 LENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTS-SSFDKTLKV----- 126 EN + + + H SV +V W PHD G+ + S D + + Sbjct: 88 EENGTWEKSHEHAG-----------HDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTG 136 Query: 127 ---WDTNTLQTADVFNFEETVYSHHMSPVS-------TKHCLV---AVGTRGPKVQLC-- 171 W+ + A ++ + P S K + A G ++L Sbjct: 137 EGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKE 196 Query: 172 -DLKSGSCSHILQGHRQEILAVSWSPRYD---YILATASADSRVKLWDVRRASGCLITLD 227 + L+ H + V+W+P +A+ S D RV +W AS + Sbjct: 197 EEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPK 256 Query: 228 QHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 + N V + ++ L G DN++ LW S Sbjct: 257 LLHKF------------NDVVWHVSWSITANILAVSGGDNKVTLWKES 292 Score = 91.1 bits (224), Expect = 8e-19, Method: Composition-based stats. Identities = 43/292 (14%), Positives = 88/292 (30%), Gaps = 55/292 (18%) Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQW-YPHDTGM 114 G + + SD + ++D+ N + + H V V W +P + Sbjct: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRG-----------HEGPVWQVAWAHPMYGNI 73 Query: 115 FTSSSFDKTLKVWDTNTLQTADVF---NFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLC 171 S S+D+ + +W + +V S +P ++A G+ + L Sbjct: 74 LASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAP-HDYGLILACGSSDGAISLL 132 Query: 172 DLK---SGSCSHILQGHRQEILAVSWS----------------PRYDYILATASADSRVK 212 I H AVSW+ P Y A+ D+ +K Sbjct: 133 TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIK 192 Query: 213 LWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD----GLHLLTVGTDNR 268 LW AH+ V + + + + D R Sbjct: 193 LWKEEEDGQWKEEQKLE-------------AHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239 Query: 269 MRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYG-STIAVY 319 + +W + + + + + + VS ++ + V G + + ++ Sbjct: 240 VFIWTCDDASSNTWSPKLLHKF--NDVVWHVSWSITANILAVSGGDNKVTLW 289 Score = 84.6 bits (207), Expect = 6e-17, Method: Composition-based stats. Identities = 39/230 (16%), Positives = 75/230 (32%), Gaps = 41/230 (17%) Query: 159 VAVGTRGPKVQLCDLKSG--SCSHILQGHRQEILAVSW-SPRYDYILATASADSRVKLWD 215 +A + V++ D+++G L+GH + V+W P Y ILA+ S D +V +W Sbjct: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 87 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD--GLHLLTVGTDNRMRLWN 273 + + H+ VN +C+ GL L +D + L Sbjct: 88 EENGTWEK--------------SHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLT 133 Query: 274 SS-NGENTLVNYGKVCNNSKKGLKFTVSCGCSS--------------EFVFVPYGSTIAV 318 + G+ + + + + S F + I + Sbjct: 134 YTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKL 193 Query: 319 Y-TVYSGEQI--TMLKGHYKTVDCCVFQSN----FQELYSGSRDCNILAW 361 + G+ L+ H V + + + S S+D + W Sbjct: 194 WKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 243 Score = 84.6 bits (207), Expect = 7e-17, Method: Composition-based stats. Identities = 50/308 (16%), Positives = 98/308 (31%), Gaps = 44/308 (14%) Query: 87 VCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA---DVFNFEET 143 + S+ H + Q + + S D+++K++D D+ E Sbjct: 1 MVSVINTVDTSHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGP 59 Query: 144 VYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSG--SCSHILQGHRQEILAVSWSPRY-DY 200 V+ ++A + KV + ++G SH GH + +V W+P Sbjct: 60 VWQVAW-AHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGL 118 Query: 201 ILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCF------- 253 ILA S+D + +L + G+ V+ N AH N + + Sbjct: 119 ILACGSSDGAI-------------SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPG 165 Query: 254 ----TSDGL------HLLTVGTDNRMRLWNSS-NGENTLVNYGKVCNNSKKGLKFTVSCG 302 G + G DN ++LW +G+ + ++ + + + S G Sbjct: 166 SLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIG 225 Query: 303 -CSSEFVFVPYGSTIAVYTVYSGEQ----ITMLKGHYKTVDCCVFQSNFQELYSGSRDCN 357 +S + ++T +L V + L D Sbjct: 226 LPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNK 285 Query: 358 ILAWVPSL 365 + W S+ Sbjct: 286 VTLWKESV 293 Score = 60.7 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 39/231 (16%), Positives = 66/231 (28%), Gaps = 40/231 (17%) Query: 184 GHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTA 243 H I Y LAT S+D VK++DVR LI + Sbjct: 11 SHEDMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNGGQILI--------------ADLRG 55 Query: 244 HNGKVNGLCFTSD--GLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSC 301 H G V + + G L + D ++ +W NG + ++S + + Sbjct: 56 HEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPH- 114 Query: 302 GCSSEFVFVPYGSTIAVYTVYSG---EQITMLKGHYKTVDCCVFQSNF------------ 346 I++ T E + H + + Sbjct: 115 DYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQ 174 Query: 347 -----QELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSSS 392 + SG D I W E +E ++ + + AW+ S Sbjct: 175 KPNYIKRFASGGCDNLIKLWKEE--EDGQWKEEQKLEAHSDWVRDVAWAPS 223 >5N4A-A nrPDB Length = 771 Score = 93.1 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 45/322 (13%), Positives = 104/322 (32%), Gaps = 41/322 (12%) Query: 30 LELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCS 89 + L + +H + + + D I +++ Q T A Sbjct: 1 MRLKVKQSSANVHSELTAAVGWNVWNE--LFTCSDDQTIHKWNMLGEPEQKVSTLDAY-- 56 Query: 90 IGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHM 149 D+H Y V + + T +F + D ++K+ + + S Sbjct: 57 ----FTDMHWYPVSSKKTQAGGTDVFAVACTDGSVKILSRTGRVEKSIEGHKGACISLRW 112 Query: 150 SPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADS 209 S T +A V++ ++G L + ++ W+ D + ++ Sbjct: 113 SYDGTA---LATAGEDGSVKIWS-RNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNV 168 Query: 210 RVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRM 269 +K S A ++A AH+G V + ++ ++T G D + Sbjct: 169 VIK------------------SLSSNAKQNAWKAHDGVVLKVDWSPINHLIITGGEDCKY 210 Query: 270 RLWNSSNGENTLVNYGKVCNNSK--KGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQI 327 ++W+S +G++ S +V+ S E V +T+ + Sbjct: 211 KVWDS---------FGRLLFQSGLFDYPVTSVAWAPSGELFAVGGFNTLQLCDRMGWAYS 261 Query: 328 TMLKGHYKTVDCCVFQSNFQEL 349 + ++ + ++ +L Sbjct: 262 KIHLNDTGSIMTLSWTADSTQL 283 Score = 79.2 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 31/210 (14%), Positives = 65/210 (30%), Gaps = 31/210 (14%) Query: 159 VAVGTRGPKVQLCDL--KSGSCSHILQG-----HRQEILAVSWSPRYDYILATASADSRV 211 + + + ++ + L H + + + A A D V Sbjct: 28 LFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKTQAGGTDVFAVACTDGSV 87 Query: 212 KLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL 271 K+ ++ VE + H G L ++ DG L T G D +++ Sbjct: 88 KI-----------------LSRTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKI 130 Query: 272 WNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLK 331 W+ + L + ++ + + C + GS + + ++ S + K Sbjct: 131 WSRN---GMLRSTLAQADSPVYSIVWAYDCDQ----LCYCTGSNVVIKSLSSNAKQNAWK 183 Query: 332 GHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 H V + + +G DC W Sbjct: 184 AHDGVVLKVDWSPINHLIITGGEDCKYKVW 213 Score = 58.8 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 40/220 (18%), Positives = 68/220 (30%), Gaps = 34/220 (15%) Query: 9 QTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVI 68 Q G D + + + ++L + H G +L +G + + G DG + Sbjct: 71 QAGGTDVFAVACTDGSVKILS-RTGRVEKSIEGHKGACISLRWS-YDGTALATAGEDGSV 128 Query: 69 VLYDLENSSRQSYYT-------------------CKAVCSIGRDHPD--------VHRYS 101 ++ R + C + + H Sbjct: 129 KIWSRNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIKSLSSNAKQNAWKAHDGV 188 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 V V W P + + + D KVWD+ F+ V S +P L AV Sbjct: 189 VLKVDWSPIN-HLIITGGEDCKYKVWDSFGRLLFQSGLFDYPVTSVAWAP---SGELFAV 244 Query: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYI 201 G +QLCD + S I I+ +SW+ + Sbjct: 245 GGFN-TLQLCDRMGWAYSKIHLNDTGSIMTLSWTADSTQL 283 Score = 56.5 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 14/109 (12%), Positives = 32/109 (29%), Gaps = 4/109 (3%) Query: 260 LLTVGTDNRMRLWN-SSNGENTLVNYGKVCNNSKKGLKFT--VSCGCSSEFVFVPYGSTI 316 L T D + WN E + + + G + F ++ Sbjct: 28 LFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKTQAGGTDVFAVACTDGSV 87 Query: 317 AVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSL 365 + + +G ++GH + + L + D ++ W + Sbjct: 88 KILS-RTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKIWSRNG 135 >4U1E-I nrPDB Length = 347 Score = 92.7 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 52/348 (14%), Positives = 105/348 (30%), Gaps = 56/348 (16%) Query: 41 IHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRY 100 H + + EG + S D ++ + + + T D H Sbjct: 8 GHERPLTQVKYN-KEGDLLFSCSKDSSASVW--YSLNGERLGTL-----------DGHTG 53 Query: 101 SVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVA 160 ++ ++ T + S D ++K+WD + Q + V SP + Sbjct: 54 TIWSIDVD-CFTKYCVTGSADYSIKLWDVSNGQCVATWKSPVPVKRVEFSPCGNYFLAIL 112 Query: 161 VGTRG--PKVQLCDLKSGSCSHILQG------HR-------QEILAVSWSPRYDYILATA 205 + + +++ S +H L H+ WS + YI+A Sbjct: 113 DNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIA-G 171 Query: 206 SADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGT 265 D ++ +DV + ++D H ++ + F+ D + +T Sbjct: 172 HKDGKISKYDVSNNYEYVDSIDL---------------HEKSISDMQFSPDLTYFITSSR 216 Query: 266 DNRMRLWNSSNGENTLVNYGKVCNNSKKGL----KFTVSCGCS-----SEFVFVPYGSTI 316 D L + S + L Y C + + +F + G + Sbjct: 217 DTNSFLVDVSTLQ-VLKKYETDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEA 275 Query: 317 AVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPS 364 Y E+I ++GH+ ++ SG D I Sbjct: 276 RFYHKIFEEEIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIRLHHFE 323 Score = 71.1 bits (172), Expect = 8e-13, Method: Composition-based stats. Identities = 40/210 (19%), Positives = 67/210 (31%), Gaps = 29/210 (13%) Query: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESAN 241 L GH + + V ++ D +L + S DS +W L TLD Sbjct: 6 LTGHERPLTQVKYNKEGD-LLFSCSKDSSASVW-YSLNGERLGTLD-------------- 49 Query: 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENT----------LVNYGKVCNNS 291 H G + + + +T D ++LW+ SNG+ V + N Sbjct: 50 -GHTGTIWSIDVDCFTKYCVTGSADYSIKLWDVSNGQCVATWKSPVPVKRVEFSPCGNYF 108 Query: 292 KKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYK--TVDCCVFQSNFQEL 349 L + S + S T S E I + H + + + + Sbjct: 109 LAILDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYI 168 Query: 350 YSGSRDCNILAWVPSLYEPVPDDDETTTKS 379 +G +D I + S D + KS Sbjct: 169 IAGHKDGKISKYDVSNNYEYVDSIDLHEKS 198 Score = 36.8 bits (83), Expect = 0.016, Method: Composition-based stats. Identities = 11/48 (22%), Positives = 18/48 (37%) Query: 329 MLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETT 376 L GH + + + L+S S+D + W E + D T Sbjct: 5 KLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHT 52 >1PI6-A nrPDB Length = 615 Score = 92.3 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 52/334 (15%), Positives = 105/334 (31%), Gaps = 35/334 (10%) Query: 39 ERIHGGGI-NTLDIEPVEG-RYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPD 96 HG + T+ P++G +Y+ SG G ++++ +V + Sbjct: 59 FTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKES-----NSVEVNVKSEFQ 113 Query: 97 VHRYSVETVQWYPHDTGM-FTSSSFDKT-LKV-WDTNTLQTADVFNFEETVYSHHMSPVS 153 V + + W + D + + WD+ +V + + + H+ Sbjct: 114 VLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGN-SLGEVSGHSQRINACHLKQSR 172 Query: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQE---ILAVSWSPRYDYILATASADSR 210 + V S + H ++ + V +SP + T +D + Sbjct: 173 PMRSM--TVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRK 230 Query: 211 VKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMR 270 + +D + D G + L + D TVG D +R Sbjct: 231 ISCFDGKSGEFLKYIEDDQEPV------------QGGIFALSWL-DSQKFATVGADATIR 277 Query: 271 LWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITML 330 +W+ + + V + + V + + + T+ Y + E + + Sbjct: 278 VWDVTTSKC--VQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTI 335 Query: 331 KGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPS 364 GH K + L SGS D I+ W S Sbjct: 336 SGHNKGITALTVNP----LISGSYDGRIMEWSSS 365 Score = 82.3 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 51/315 (16%), Positives = 111/315 (35%), Gaps = 25/315 (7%) Query: 46 INTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETV 105 + ++ P G ++++ GSD I +D ++ Y G + + Sbjct: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGG---------IFAL 259 Query: 106 QWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYS-HHMSPVSTKHCLVAVGTR 164 W D+ F + D T++VWD T + + ++ + V+T + + + Sbjct: 260 SW--LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSL 317 Query: 165 GPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRA----S 220 + +L + GH + I A++ +P L + S D R+ W S Sbjct: 318 DGTLNFYELGHDEVLKTISGHNKGITALTVNP-----LISGSYDGRIMEWSSSSMHQDHS 372 Query: 221 GCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENT 280 +++LD ++ ++ +T + F S + + D + + + Sbjct: 373 NLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGS-QPKVASANNDGFTAVLTNDDDLLI 431 Query: 281 LVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPY--GSTIAVYTVYSGEQITMLKGHYKT-V 337 L ++ S + + S +V V G+TI V+ + E LK + Sbjct: 432 LQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKP 491 Query: 338 DCCVFQSNFQELYSG 352 + + +G Sbjct: 492 SYISISPSETYIAAG 506 Score = 77.7 bits (189), Expect = 7e-15, Method: Composition-based stats. Identities = 38/268 (14%), Positives = 83/268 (30%), Gaps = 33/268 (12%) Query: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 H IN ++ ++ G DG +V Y + + + + G Sbjct: 157 SGHSQRINACHLKQSRPMRSMTVGDDGSVVFY--QGPPFKFSASDRTHHKQG-------- 206 Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTKHCL 158 V V++ P + D+ + +D + + +E V + Sbjct: 207 SFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQK 266 Query: 159 VAVGTRGPKVQLCDLKSGSCSHILQGHRQEI--LAVSWSPRYDYILATASADSRVKLWDV 216 A +++ D+ + C +Q++ V + + + S D + +++ Sbjct: 267 FATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYEL 326 Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN 276 V + HN + L L++ D R+ W+SS+ Sbjct: 327 GHDE----------------VLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSS 366 Query: 277 GENTLVNYGKVCNNSKKGLKFTVSCGCS 304 N +NSK ++S + Sbjct: 367 MHQDHSNLIVSLDNSKAQEYSSISWDDT 394 Score = 57.2 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 49/352 (13%), Positives = 104/352 (29%), Gaps = 63/352 (17%) Query: 20 RAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQ 79 + T L ++ H GI L + P ++SG DG I+ + + Sbjct: 316 SLDGTLNFYELGHDEVLKTISGHNKGITALTVNP-----LISGSYDGRIMEWSSSS---- 366 Query: 80 SYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN 139 H + V ++S S+D TLKV T F Sbjct: 367 --------------MHQDHSNLI--VSLDNSKAQEYSSISWDDTLKV----NGITKHEFG 406 Query: 140 FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYD 199 + V S + AV T + + +G ++ + AVS S + Sbjct: 407 SQPKVAS------ANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPG-SAVSLS--QN 457 Query: 200 YILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLH 259 Y+ + ++++ + ++ D +++ + + + Sbjct: 458 YVAVGLEEGNTIQVFKLSD---LEVSFDLKTPLRAKPSY------------ISISPSETY 502 Query: 260 LLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCG-------CSSEFVFVPY 312 + ++ L++ + E + + + + + Sbjct: 503 IAAGDVMGKILLYDLQSRE-VKTSRWAFRTSKINAISWKPAEKGANEEEIEEDLVATGSL 561 Query: 313 GSTIAVYTVYSG-EQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVP 363 + I +Y+V + I L H V+ ++ L S D I W Sbjct: 562 DTNIFIYSVKRPMKIIKALNAHKDGVNNLLW-ETPSTLVSSGADACIKRWNV 612 Score = 52.6 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 45/290 (15%), Positives = 87/290 (30%), Gaps = 59/290 (20%) Query: 133 QTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGS--CSHILQGH-RQEI 189 + + ++ H+S T + + + V+ D GH + Sbjct: 8 EIIPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVV 67 Query: 190 LAVSWSP-RYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKV 248 V +SP + L + +V +W T D+ + V+S G + Sbjct: 68 TTVKFSPIKGSQYLCSGDESGKVIVW--------GWTFDKESNSVEVNVKSEFQVLAGPI 119 Query: 249 NGLCFTSDGLHLLTVGT--DN--RMRLWNSSN------GENTLVNY-------------- 284 + + + +G L VG DN W+S N G + +N Sbjct: 120 SDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTV 179 Query: 285 -------------------GKVCNNSKKGLKFTVSCGCSSEFV-FVPYGSTIAVYTVYSG 324 + + ++ S EFV V I+ + SG Sbjct: 180 GDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSG 239 Query: 325 EQITMLKGHYKTVDCCVF---QSNFQELYSGSRDCNILAWVPSLYEPVPD 371 E + ++ + V +F + Q+ + D I W + + V Sbjct: 240 EFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQK 289 >4OWR-A nrPDB Length = 339 Score = 92.3 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 44/333 (13%), Positives = 102/333 (30%), Gaps = 41/333 (12%) Query: 35 DRDVERIHGGGINTLDIEPVE--GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGR 92 D +V I L P G ++++G + +++++S + + Sbjct: 2 DIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQ------- 54 Query: 93 DHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPV 152 +H V V W + +F ++S DKT K+WD ++ Q + + V + H Sbjct: 55 ----MHTGPVLDVCWSDDGSKVF-TASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKA 109 Query: 153 STKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDY-ILATASADSRV 211 C V G+ ++ D +S + +LQ + + Y + A+A+ + Sbjct: 110 PNYSC-VMTGSWDKTLKFWDTRSSNPMMVLQ-----LPERCYCADVIYPMAVVATAERGL 163 Query: 212 KLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL 271 ++ + ++ + + V N + R+ + Sbjct: 164 IVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKP----------TGFALGSIEGRVAI 213 Query: 272 WNSSNGENTLVNYGKVCNNSKK----------GLKFTVSCGCSSEFVFVPYGSTIAVYTV 321 + N+ C+ S + V + + Sbjct: 214 HYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDK 273 Query: 322 YSGEQITMLKGHYKTVDCCVFQSNFQELYSGSR 354 + ++ + + + C F N S Sbjct: 274 DARTKLKTSEQLDQPISACCFNHNGNIFAYASS 306 Score = 72.3 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 50/278 (17%), Positives = 87/278 (31%), Gaps = 32/278 (11%) Query: 38 VERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDV 97 +++H G + + +G + + D ++DL ++ Sbjct: 52 AQQMHTGPVLDVCWS-DDGSKVFTASCDKTAKMWDLSSNQAIQIA--------------Q 96 Query: 98 HRYSVETVQW-YPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKH 156 H V+T+ W + + S+DKTLK WDT + V E Y + V Sbjct: 97 HDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYC---ADVIYPM 153 Query: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYD---YILATASADSRVKL 213 +VA RG V + + I + + V+ A S + RV + Sbjct: 154 AVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAI 213 Query: 214 WDVRRASGCL--ITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL 271 + + T H + + VNG+ F L TVG+D R Sbjct: 214 HYINPPNPAKDNFTFKCHRSNGTNTSAPQDI---YAVNGIAFHPVHGTLATVGSDGRFSF 270 Query: 272 WNSSNGENTLVNYG-----KVCNNSKKGLKFTVSCGCS 304 W+ + C + G F + Sbjct: 271 WDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASSYD 308 Score = 68.8 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 20/130 (15%), Positives = 43/130 (33%), Gaps = 9/130 (6%) Query: 245 NGKVNGLCFTSD---GLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSC 301 + + L F+ G L+ N +R W + T+ ++ + Sbjct: 10 DDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHT---GPVLDVCWS 66 Query: 302 GCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVF--QSNFQELYSGSRDCNIL 359 S+ T ++ + S + I + + H V + N+ + +GS D + Sbjct: 67 DDGSKVFTASCDKTAKMWDLSSNQAIQIAQ-HDAPVKTIHWIKAPNYSCVMTGSWDKTLK 125 Query: 360 AWVPSLYEPV 369 W P+ Sbjct: 126 FWDTRSSNPM 135 Score = 63.0 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 37/297 (12%), Positives = 78/297 (26%), Gaps = 45/297 (15%) Query: 100 YSVETVQWYPHD--TGMFTSSSFDKTLKVWDT-NTLQTADVFN--FEETVYSHHMSPVST 154 S+ + + P + S+ ++ W+ ++ QT V S + Sbjct: 11 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGS 70 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYI-LATASADSRVKL 213 K V + ++ DL S I Q H + + W +Y + T S D +K Sbjct: 71 K---VFTASCDKTAKMWDLSSNQAIQIAQ-HDAPVKTIHWIKAPNYSCVMTGSWDKTLKF 126 Query: 214 WDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 WD R S + + + + + + ++ Sbjct: 127 WDTRS---------------SNPMMVLQLPERCYCADVIY----PMAVVATAERGLIVYQ 167 Query: 274 SSNGENTLVNYGKVCNNSKKGLK-FTVSCGCSSEFVFVPYGSTIAVYTVYSGEQIT---M 329 N + + + + F + F +A++ + Sbjct: 168 LENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFT 227 Query: 330 LKGHYK------------TVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDE 374 K H V+ F L + D W + ++ Sbjct: 228 FKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQ 284 >6CB1-s nrPDB Length = 569 Score = 91.1 bits (224), Expect = 7e-19, Method: Composition-based stats. Identities = 52/386 (13%), Positives = 109/386 (28%), Gaps = 65/386 (16%) Query: 12 LEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLY 71 L P LR + H G + TL I+P G ++ +G DG + ++ Sbjct: 178 LPSPKDLRPFPIRCST----------IYAGHKGKVRTLSIDP-SGLWLATGSDDGTVRVW 226 Query: 72 DLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKV----- 126 ++ + ++PD H +E ++W P + + + + + Sbjct: 227 EILTGRE----VYRTTLIDDEENPDYH---IECIEWNPDANNGILAVAVGENIHLIVPPI 279 Query: 127 --WDT-NTLQTADVFNFEETVYSHHMSP----------VSTKHCLVAVGTRGPKVQLCDL 173 +D N +T F + A +V + Sbjct: 280 FGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNK 339 Query: 174 KSGSCSH----ILQGHRQEILAVSWSPRYDYILATA--SADSRVKLWDVRRASGCLITLD 227 S I ++ + +SW + DY + S ++ V + V + Sbjct: 340 PSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSK--------- 390 Query: 228 QHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKV 287 +S G + F L +R+++ S Sbjct: 391 -------HLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGA 442 Query: 288 CNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGE-QITMLKGHYKTVDCCVFQSNF 346 SK + + + + + + L+ H K V F Sbjct: 443 RWLSKIDIH-----PRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKL 497 Query: 347 QELYSGSRDCNILAWVPSLYEPVPDD 372 S + D I + ++Y+ + + Sbjct: 498 PLFSSAADDGTIHVFHATVYDDMMKN 523 Score = 72.6 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 24/179 (13%), Positives = 60/179 (33%), Gaps = 17/179 (9%) Query: 99 RYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCL 158 + + +++P +F S + ++++D + S + + Sbjct: 401 KGIIMDAKFHPFKPQLFVCSQ--RYVRIYDLSQQILVKKLLPGARWLSK--IDIHPRGDN 456 Query: 159 VAVGTRGPKVQLCDLK-SGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 + + +V DL + + L+ H + + +V++ + + ++A+ D + ++ Sbjct: 457 LIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIHVF--- 512 Query: 218 RASGCLITLDQHNGKKSQAVESANTAH----NGKVNGLCFTSDGLHLLTVGTDNRMRLW 272 D T H + V + L + G DN RLW Sbjct: 513 ----HATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 567 Score = 69.6 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 38/272 (13%), Positives = 79/272 (29%), Gaps = 69/272 (25%) Query: 99 RYSVETVQWYPHDTGMFTSSSFDK---TLKVWDTNTLQTADVFNFEETV-YSHHMSPVST 154 + +V+ + W+ F + D ++ + + T F + + P Sbjct: 356 KKTVKKLSWH-RKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKP 414 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLW 214 + + + V++ DL L + + + PR D ++A+ S D RV Sbjct: 415 QLFVCSQ----RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIAS-SFDKRVLWH 469 Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 D+ AS TL H V + F + D + ++++ Sbjct: 470 DLDLASTPYKTLRY---------------HEKAVRSVNFHKKLPLFSSAADDGTIHVFHA 514 Query: 275 SNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHY 334 + ++ + N V + L GH Sbjct: 515 TVYDDMMKNPMIV--------------------------------------PLKKLTGH- 535 Query: 335 KTVDCC-----VFQSNFQELYSGSRDCNILAW 361 K ++ ++ L+S D W Sbjct: 536 KVINSLGVLDAIWHPREAWLFSAGADNTARLW 567 Score = 48.8 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 13/73 (17%), Positives = 20/73 (27%), Gaps = 1/73 (1%) Query: 325 EQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPA 384 T+ GH V + L +GS D + W V + + Sbjct: 190 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 249 Query: 385 FEDA-WSSSDEEG 396 E W+ G Sbjct: 250 IECIEWNPDANNG 262 >6C0F-s nrPDB Length = 807 Score = 90.7 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 52/386 (13%), Positives = 109/386 (28%), Gaps = 65/386 (16%) Query: 12 LEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLY 71 L P LR + H G + TL I+P G ++ +G DG + ++ Sbjct: 416 LPSPKDLRPFPIRCST----------IYAGHKGKVRTLSIDP-SGLWLATGSDDGTVRVW 464 Query: 72 DLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKV----- 126 ++ + ++PD H +E ++W P + + + + + Sbjct: 465 EILTGRE----VYRTTLIDDEENPDYH---IECIEWNPDANNGILAVAVGENIHLIVPPI 517 Query: 127 --WDT-NTLQTADVFNFEETVYSHHMSP----------VSTKHCLVAVGTRGPKVQLCDL 173 +D N +T F + A +V + Sbjct: 518 FGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNK 577 Query: 174 KSGSCSH----ILQGHRQEILAVSWSPRYDYILATA--SADSRVKLWDVRRASGCLITLD 227 S I ++ + +SW + DY + S ++ V + V + Sbjct: 578 PSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSK--------- 628 Query: 228 QHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKV 287 +S G + F L +R+++ S Sbjct: 629 -------HLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGA 680 Query: 288 CNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGE-QITMLKGHYKTVDCCVFQSNF 346 SK + + + + + + L+ H K V F Sbjct: 681 RWLSKIDIH-----PRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKL 735 Query: 347 QELYSGSRDCNILAWVPSLYEPVPDD 372 S + D I + ++Y+ + + Sbjct: 736 PLFSSAADDGTIHVFHATVYDDMMKN 761 Score = 72.3 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 24/179 (13%), Positives = 60/179 (33%), Gaps = 17/179 (9%) Query: 99 RYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCL 158 + + +++P +F S + ++++D + S + + Sbjct: 639 KGIIMDAKFHPFKPQLFVCSQ--RYVRIYDLSQQILVKKLLPGARWLSK--IDIHPRGDN 694 Query: 159 VAVGTRGPKVQLCDLK-SGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 + + +V DL + + L+ H + + +V++ + + ++A+ D + ++ Sbjct: 695 LIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIHVF--- 750 Query: 218 RASGCLITLDQHNGKKSQAVESANTAH----NGKVNGLCFTSDGLHLLTVGTDNRMRLW 272 D T H + V + L + G DN RLW Sbjct: 751 ----HATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 69.2 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 38/272 (13%), Positives = 79/272 (29%), Gaps = 69/272 (25%) Query: 99 RYSVETVQWYPHDTGMFTSSSFDK---TLKVWDTNTLQTADVFNFEETV-YSHHMSPVST 154 + +V+ + W+ F + D ++ + + T F + + P Sbjct: 594 KKTVKKLSWH-RKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKP 652 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLW 214 + + + V++ DL L + + + PR D ++A+ S D RV Sbjct: 653 QLFVCSQ----RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIAS-SFDKRVLWH 707 Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 D+ AS TL H V + F + D + ++++ Sbjct: 708 DLDLASTPYKTLRY---------------HEKAVRSVNFHKKLPLFSSAADDGTIHVFHA 752 Query: 275 SNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHY 334 + ++ + N V + L GH Sbjct: 753 TVYDDMMKNPMIV--------------------------------------PLKKLTGH- 773 Query: 335 KTVDCC-----VFQSNFQELYSGSRDCNILAW 361 K ++ ++ L+S D W Sbjct: 774 KVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 48.4 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 13/73 (17%), Positives = 20/73 (27%), Gaps = 1/73 (1%) Query: 325 EQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPA 384 T+ GH V + L +GS D + W V + + Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 487 Query: 385 FEDA-WSSSDEEG 396 E W+ G Sbjct: 488 IECIEWNPDANNG 500 >6EM1-m nrPDB Length = 807 Score = 90.4 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 52/386 (13%), Positives = 109/386 (28%), Gaps = 65/386 (16%) Query: 12 LEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLY 71 L P LR + H G + TL I+P G ++ +G DG + ++ Sbjct: 416 LPSPKDLRPFPIRCST----------IYAGHKGKVRTLSIDP-SGLWLATGSDDGTVRVW 464 Query: 72 DLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKV----- 126 ++ + ++PD H +E ++W P + + + + + Sbjct: 465 EILTGRE----VYRTTLIDDEENPDYH---IECIEWNPDANNGILAVAVGENIHLIVPPI 517 Query: 127 --WDT-NTLQTADVFNFEETVYSHHMSP----------VSTKHCLVAVGTRGPKVQLCDL 173 +D N +T F + A +V + Sbjct: 518 FGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNK 577 Query: 174 KSGSCSH----ILQGHRQEILAVSWSPRYDYILATA--SADSRVKLWDVRRASGCLITLD 227 S I ++ + +SW + DY + S ++ V + V + Sbjct: 578 PSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSK--------- 628 Query: 228 QHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKV 287 +S G + F L +R+++ S Sbjct: 629 -------HLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGA 680 Query: 288 CNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGE-QITMLKGHYKTVDCCVFQSNF 346 SK + + + + + + L+ H K V F Sbjct: 681 RWLSKIDIH-----PRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKL 735 Query: 347 QELYSGSRDCNILAWVPSLYEPVPDD 372 S + D I + ++Y+ + + Sbjct: 736 PLFSSAADDGTIHVFHATVYDDMMKN 761 Score = 72.3 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 24/179 (13%), Positives = 60/179 (33%), Gaps = 17/179 (9%) Query: 99 RYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCL 158 + + +++P +F S + ++++D + S + + Sbjct: 639 KGIIMDAKFHPFKPQLFVCSQ--RYVRIYDLSQQILVKKLLPGARWLSK--IDIHPRGDN 694 Query: 159 VAVGTRGPKVQLCDLK-SGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 + + +V DL + + L+ H + + +V++ + + ++A+ D + ++ Sbjct: 695 LIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIHVF--- 750 Query: 218 RASGCLITLDQHNGKKSQAVESANTAH----NGKVNGLCFTSDGLHLLTVGTDNRMRLW 272 D T H + V + L + G DN RLW Sbjct: 751 ----HATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 69.2 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 38/272 (13%), Positives = 79/272 (29%), Gaps = 69/272 (25%) Query: 99 RYSVETVQWYPHDTGMFTSSSFDK---TLKVWDTNTLQTADVFNFEETV-YSHHMSPVST 154 + +V+ + W+ F + D ++ + + T F + + P Sbjct: 594 KKTVKKLSWH-RKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKP 652 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLW 214 + + + V++ DL L + + + PR D ++A+ S D RV Sbjct: 653 QLFVCSQ----RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIAS-SFDKRVLWH 707 Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 D+ AS TL H V + F + D + ++++ Sbjct: 708 DLDLASTPYKTLRY---------------HEKAVRSVNFHKKLPLFSSAADDGTIHVFHA 752 Query: 275 SNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHY 334 + ++ + N V + L GH Sbjct: 753 TVYDDMMKNPMIV--------------------------------------PLKKLTGH- 773 Query: 335 KTVDCC-----VFQSNFQELYSGSRDCNILAW 361 K ++ ++ L+S D W Sbjct: 774 KVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 48.4 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 13/73 (17%), Positives = 20/73 (27%), Gaps = 1/73 (1%) Query: 325 EQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPA 384 T+ GH V + L +GS D + W V + + Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 487 Query: 385 FEDA-WSSSDEEG 396 E W+ G Sbjct: 488 IECIEWNPDANNG 500 >3ACP-A nrPDB Length = 417 Score = 88.1 bits (216), Expect = 5e-18, Method: Composition-based stats. Identities = 50/343 (14%), Positives = 109/343 (31%), Gaps = 68/343 (19%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 L E +VL N R++++ H I L P G ++S D + ++ +++ Sbjct: 109 FILGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFP-SGEALISSSQDMQLKIWSVKD 167 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA 135 S HR +V + + S+S D T+++W+ T T Sbjct: 168 GSNPRTLIG-------------HRATVTDIAIIDRGRNVL-SASLDGTIRLWECGTGTTI 213 Query: 136 DVFNFEETVYSHHMSP---VSTKHCLVAVGTRGPKVQLCDLKSGSC-SHILQGHRQEI-- 189 FN +E + S V T L + T +L+ G+ +++ GH + Sbjct: 214 HTFNRKENPHDGVNSIALFVGTDRQLHEISTSKKN----NLEFGTYGKYVIAGHVSGVIT 269 Query: 190 ---------------------LAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQ 228 +++ + + + WD+R + Sbjct: 270 VHNVFSKEQTIQLPSKFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLI 329 Query: 229 HNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL---WNSSNGENTLVNYG 285 + G +N + F + G ++ G D ++L + + + Sbjct: 330 NEGT--------------PINNVYFAA-GALFVSSGFDTSIKLDIISDPESERPAIEFET 374 Query: 286 KVC----NNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSG 324 ++ + + E + V + A+Y + + Sbjct: 375 PTFLVSNDDEVSQFCYVSDDESNGEVLEVGKNNFCALYNLSNP 417 Score = 76.5 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 43/272 (15%), Positives = 93/272 (34%), Gaps = 25/272 (9%) Query: 103 ETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCL---- 158 V F + + +KV D+N FN + + H+S ++ Sbjct: 97 TAVDTAKLQMRRFILGTTEGDIKVLDSN-------FNLQREIDQAHVSEITKLKFFPSGE 149 Query: 159 -VAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 + ++ ++++ +K GS L GHR + ++ R +L +AS D ++LW+ Sbjct: 150 ALISSSQDMQLKIWSVKDGSNPRTLIGHRATVTDIAIIDRGRNVL-SASLDGTIRLWECG 208 Query: 218 RASGCLITLDQHNGKKSQAVESANTAHNGKV--------NGLCFTSDGLHLLTVGTDNRM 269 + + N + + ++ N L F + G +++ + Sbjct: 209 TGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVI 268 Query: 270 RLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQ-IT 328 + N + E T+ K + TV ++ +A + + S E + Sbjct: 269 TVHNVFSKEQTIQLPSKF---TCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVG 325 Query: 329 MLKGHYKTVDCCVFQSNFQELYSGSRDCNILA 360 + T V+ + S D +I Sbjct: 326 EFLINEGTPINNVYFAAGALFVSSGFDTSIKL 357 Score = 52.6 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 18/112 (16%), Positives = 35/112 (31%), Gaps = 5/112 (4%) Query: 258 LHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIA 317 + T+ +++ +S+ N + + LKF + + Sbjct: 107 RRFILGTTEGDIKVLDSNF--NLQREIDQAHVSEITKLKF---FPSGEALISSSQDMQLK 161 Query: 318 VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPV 369 +++V G L GH TV + + S S D I W + Sbjct: 162 IWSVKDGSNPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTI 213 >4G56-B nrPDB Length = 357 Score = 87.7 bits (215), Expect = 7e-18, Method: Composition-based stats. Identities = 48/232 (20%), Positives = 81/232 (34%), Gaps = 37/232 (15%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H + TL + +G +SGG D + ++DL + Y + H Sbjct: 138 HDDIVKTLSVF-SDGTQAVSGGKDFSVKVWDLSQKAVLKSY-------------NAHSSE 183 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNF---EETVYSHHMSPVSTKHCL 158 V V P +F S D + +WDT + A +F + S P Sbjct: 184 VNCVAACPGKDTIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTF- 242 Query: 159 VAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRR 218 A G V L ++K+ + H Q I +++S LA+ S D V + D Sbjct: 243 -ACGDETGNVSLVNIKNPDSAQTSAVHSQNITGLAYSYHSSPFLASISEDCTVAVLDADF 301 Query: 219 ASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS-DGLHLLTVGTDNRM 269 + + +H V G+ ++ D TVG D+++ Sbjct: 302 SEVFR-----------------DLSHRDFVTGVAWSPLDHSKFTTVGWDHKV 336 Score = 83.8 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 41/261 (15%), Positives = 75/261 (28%), Gaps = 23/261 (8%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQT--ADVFNFEETVYSHHMSPVSTK 155 V V W + S S +++W+ ++ + F E V + Sbjct: 93 TEAGVTDVAWVSEKGILVASDS--GAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSD 150 Query: 156 HCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 G + V++ DL + H E+ V+ P D I + D R+ LWD Sbjct: 151 GTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWD 210 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 R+ A A + + + + G D + + Sbjct: 211 TRK--------------PKPATRIDFCASDTIPTSVTWHPEKDDTFACG-DETGNVSLVN 255 Query: 276 NGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYK 335 V + + GL ++ S + T+AV E L H Sbjct: 256 IKNPDSAQTSAVHSQNITGLAYSYHS--SPFLASISEDCTVAVLDADFSEVFRDLS-HRD 312 Query: 336 TVDCCVFQS-NFQELYSGSRD 355 V + + + + D Sbjct: 313 FVTGVAWSPLDHSKFTTVGWD 333 Score = 77.7 bits (189), Expect = 8e-15, Method: Composition-based stats. Identities = 35/200 (17%), Positives = 61/200 (30%), Gaps = 15/200 (7%) Query: 22 ESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSY 81 + + +V L H +N + P + LS G DG I+L+D + Sbjct: 160 DFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRKPKPATR 219 Query: 82 YTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN-F 140 A +I +V W+P F + + + +A Sbjct: 220 IDFCASDTIP-----------TSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAVH 268 Query: 141 EETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDY 200 + + S S+ +A + V + D L HR + V+WSP Sbjct: 269 SQNITGLAYSYHSS--PFLASISEDCTVAVLDADFSEVFRDL-SHRDFVTGVAWSPLDHS 325 Query: 201 ILATASADSRVKLWDVRRAS 220 T D +V + Sbjct: 326 KFTTVGWDHKVLHHHLPSEG 345 Score = 62.2 bits (149), Expect = 3e-10, Method: Composition-based stats. Identities = 32/186 (17%), Positives = 61/186 (32%), Gaps = 8/186 (4%) Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN 276 R G + G ++++ +A V + + S+ L+ + LW Sbjct: 66 RTWGGSIWVFKDPEGAPNESLCTAGVQTEAGVTDVAWVSEKGILV-ASDSGAVELWEILE 124 Query: 277 GENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKT 336 E+ LVN + +K ++ V ++ V+ + + H Sbjct: 125 KESLLVNKFAKYEH-DDIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSE 183 Query: 337 VDCCVFQSNFQELY-SGSRDCNILAWVPSLYEPVPD-----DDETTTKSQLNPAFEDAWS 390 V+C ++ S D IL W +P D T +P +D ++ Sbjct: 184 VNCVAACPGKDTIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFA 243 Query: 391 SSDEEG 396 DE G Sbjct: 244 CGDETG 249 Score = 48.4 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 18/112 (16%), Positives = 32/112 (28%), Gaps = 14/112 (12%) Query: 13 EDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYD 72 +D ++ ++ +H I L ++ S D + + D Sbjct: 239 DDTFACGDETGNVSLVNIKNPDSAQTSAVHSQNITGLAYSYHSSPFLASISEDCTVAVLD 298 Query: 73 LENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTL 124 + S HR V V W P D FT+ +D + Sbjct: 299 ADFSEVFR--------------DLSHRDFVTGVAWSPLDHSKFTTVGWDHKV 336 >6F1U-h nrPDB Length = 612 Score = 86.9 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 44/315 (13%), Positives = 97/315 (30%), Gaps = 27/315 (8%) Query: 99 RYSVETVQWYPHDTGMFTSSSF---------DKTLKVWDTNTLQTADVFNFEETVYSHHM 149 V + W + +S D VW+ +T + F Sbjct: 253 HRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSA 312 Query: 150 SPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQ------GHRQEILAV-SWSPRYDYIL 202 + LV GT ++ L D +S + + + H + V + + L Sbjct: 313 TFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNL 372 Query: 203 ATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLT 262 + S D ++ W + S +++ + + ++ + G VN S+ + T Sbjct: 373 ISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYT 432 Query: 263 VGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVY 322 S G + + + + S FV + T+ +++ Sbjct: 433 ACRHG------SKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTK 486 Query: 323 SGEQITMLKGHYKTVDCCVFQSNFQELYSGSRD-CNILAWVPSLYEPVPDDDETTTKSQL 381 + + + + + V ++ L++ + W + VP + + Sbjct: 487 NNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPT---ASISVEG 543 Query: 382 NPAFEDA-WSSSDEE 395 NPA W+ S E Sbjct: 544 NPALNRVRWTHSGRE 558 Score = 80.0 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 37/274 (13%), Positives = 85/274 (31%), Gaps = 35/274 (12%) Query: 27 VLGLELNKDRDVER------IHGGGINTLDIEPVEGRY-MLSGGSDGVIVLYDLENSSRQ 79 + NK V+R H + +++ + + ++S +DG I + L+ S Sbjct: 333 LWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLS-- 390 Query: 80 SYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF- 138 S+ H +V ++ + D F S + ++ A + Sbjct: 391 -----HPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYT-ACRHGSKAGISE 444 Query: 139 ------NFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAV 192 ++ H L + V+L K+ + + + + V Sbjct: 445 MFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNNKPLYSFEDNAGYVYDV 504 Query: 193 SWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLC 252 WSP + + A R+ LW++ + G N +N + Sbjct: 505 MWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEG-------------NPALNRVR 551 Query: 253 FTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGK 286 +T G + ++ ++ +++ N Sbjct: 552 WTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDEW 585 >3F3P-A nrPDB Length = 351 Score = 84.2 bits (206), Expect = 8e-17, Method: Composition-based stats. Identities = 52/357 (14%), Positives = 111/357 (31%), Gaps = 58/357 (16%) Query: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 H ++ + + GR++ + SD I ++ L+ + D H Sbjct: 8 SGHDDLVHDVVYD-FYGRHVATCSSDQHIKVFKLDKDT---------SNWELSDSWRAHD 57 Query: 100 YSVETVQW-YPHDTGMFTSSSFDKTLKVWDTNTLQTA----------DVFNFEETVYSHH 148 S+ + W P + S+S+DKT+K+W+ + Q + + + ++YS Sbjct: 58 SSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVK 117 Query: 149 MSPVSTKHCLVAVGTRGPKVQLCD------LKSGSCSHILQ-------GHRQEILAVSWS 195 +P L +G ++L D L+S + + ++ H Q +SW Sbjct: 118 FAPAHLGLKLACLG-NDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWC 176 Query: 196 PRY---DYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLC 252 P + + +A + Q V + H + + Sbjct: 177 PSRFSPEKLAVSA---------------LEQAIIYQRGKDGKLHVAAKLPGHKSLIRSIS 221 Query: 253 FTSD----GLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFV 308 + + T D R+R++ + + L + + N++ V Sbjct: 222 WAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSD 281 Query: 309 FVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSL 365 + E ++ H V + L S D + W + Sbjct: 282 SNTEEKAELQSNLQV-ELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATY 337 Score = 77.7 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 53/315 (16%), Positives = 109/315 (34%), Gaps = 59/315 (18%) Query: 16 LRLRRAESTRRVLGLELNKDR----DVERIHGGGINTLDI-EPVEGRYMLSGGSDGVIVL 70 + ++ +V L+ + D R H I +D P GR + S D + L Sbjct: 26 VATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKL 85 Query: 71 YDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSS-SFDKTLKVWD- 128 ++ C + + S+ +V++ P G+ + D L+++D Sbjct: 86 WE----EDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDA 141 Query: 129 -----------TNTLQTADV--FNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKS 175 T+ ++ + N ++ + P +AV + K Sbjct: 142 LEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKD 201 Query: 176 GSC--SHILQGHRQEILAVSWSP---RYDYILATASADSRVKLWDVRRASGCLITLDQHN 230 G + L GH+ I ++SW+P R+ ++AT D R++++ + L + + Sbjct: 202 GKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLT 261 Query: 231 GKK------------------------------SQAVESANTAHNGKVNGLCFTSDGLHL 260 + S + HNG+V + + G L Sbjct: 262 NSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTIL 321 Query: 261 LTVGTDNRMRLWNSS 275 + G D ++RLW ++ Sbjct: 322 SSAGDDGKVRLWKAT 336 Score = 70.3 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 49/259 (18%), Positives = 86/259 (33%), Gaps = 31/259 (11%) Query: 147 HHMSPVSTKHCLVAVGTRGPKVQLC----DLKSGSCSHILQGHRQEILAVSW-SPRYDYI 201 H VA + +++ D + S + H I+A+ W SP Y I Sbjct: 14 VHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRI 73 Query: 202 LATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD--GLH 259 +A+AS D VKLW+ +G++ + + N G + + F GL Sbjct: 74 IASASYDKTVKLWEEDPDQEEC------SGRRWNKLCTLN-DSKGSLYSVKFAPAHLGLK 126 Query: 260 LLTVGTDNRMRL-----------WNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFV 308 L +G D +RL W ++ L S L + S + Sbjct: 127 LACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLA 186 Query: 309 FVPYGSTIAVYTVYSGEQ--ITMLKGHYKTVDCCVFQSN----FQELYSGSRDCNILAWV 362 I G+ L GH + + + +Q + +G +D I + Sbjct: 187 VSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFK 246 Query: 363 PSLYEPVPDDDETTTKSQL 381 + +E+ T S + Sbjct: 247 ITEKLSPLASEESLTNSNM 265 Score = 39.1 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 8/87 (9%), Positives = 29/87 (33%), Gaps = 1/87 (1%) Query: 237 VESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLK 296 ++ ++ H+ V+ + + G H+ T +D ++++ + + + Sbjct: 3 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 62 Query: 297 FTVSCG-CSSEFVFVPYGSTIAVYTVY 322 + Y T+ ++ Sbjct: 63 IDWASPEYGRIIASASYDKTVKLWEED 89 Score = 34.9 bits (78), Expect = 0.070, Method: Composition-based stats. Identities = 13/63 (20%), Positives = 25/63 (39%), Gaps = 4/63 (6%) Query: 19 RRAESTRRVLGLELNKDRDV---ERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 R +T L+ N ++ H G + ++ + G + S G DG + L+ Sbjct: 279 RSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWN-LTGTILSSAGDDGKVRLWKATY 337 Query: 76 SSR 78 S+ Sbjct: 338 SNE 340 >5OQL-X nrPDB Length = 630 Score = 83.8 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 51/357 (14%), Positives = 101/357 (28%), Gaps = 60/357 (16%) Query: 39 ERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSR-------------------- 78 R + G + ++ + P Y + DG + + L++ + Sbjct: 166 FRWNSGTVTSVAVCP---PYAYTTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKPPAPPKK 222 Query: 79 --QSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTAD 136 + KA D V D + DK L V++ L+ Sbjct: 223 RPERICFAKADARKANDKTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIK 282 Query: 137 VFN-FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 195 F + V + ++ V++ L + L GH+ EIL + + Sbjct: 283 AFTQHRDAVTGLAFR---RGTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDID-A 338 Query: 196 PRYDYILATASADSRVKLWDVRRASGCLITLDQHNG-------KKSQAVESANTAHNGKV 248 + ++ + D + W V S + G K ++ A+ AH G + Sbjct: 339 LGQERCVSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSM 398 Query: 249 NGLCFTSDGLHLLTVGTDNRMRLWNSSNGENT-LVNYGKVCNNSKKGLKFTVSCGCSSEF 307 + + D +T + + LW+ + ++ K ++ Sbjct: 399 DRVAMIDDD-MFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSI 457 Query: 308 VFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPS 364 + P I ++SGS D I W S Sbjct: 458 IPAPQPRGI---------------------TALRTLPYSDLIFSGSWDGCIRVWRLS 493 Score = 79.6 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 45/286 (15%), Positives = 91/286 (31%), Gaps = 53/286 (18%) Query: 34 KDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRD 93 + + H + +G+++++GG+D +V+Y+ + +T Sbjct: 237 ANDKTYQGHLKAPLVVKASQ-DGKFVVTGGADKRLVVYNAADLKPIKAFTQ--------- 286 Query: 94 HPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVS 153 HR +V + + T S S D+T+KVW + L + F + + Sbjct: 287 ----HRDAVTGLAFR-RGTNQLYSCSKDRTVKVWSLDELAYVETL-FGHQDEILDIDALG 340 Query: 154 TKHCLVAVGTRGPKVQLCDL---------------KSGSCSHILQ--------GHRQEIL 190 + C V+VG R + + S + H L H + Sbjct: 341 QERC-VSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMD 399 Query: 191 AVSWSPRYDYILATASADSRVKLWDVRRAS-----------GCLITLDQHNGKKSQAVES 239 V+ + T S + + LW ++R I L+ ++ + Sbjct: 400 RVAMIDDD--MFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSI 457 Query: 240 ANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYG 285 + L + + D +R+W S + L G Sbjct: 458 IPAPQPRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDKRKLEAVG 503 Score = 60.7 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 42/297 (14%), Positives = 78/297 (26%), Gaps = 63/297 (21%) Query: 99 RYSVETVQWYPHDTGMFTSSSFDKTLKVW---DTNTLQTADVFNFEETVYSHHMSPVSTK 155 +V +V P +++ D L W D Q + + Sbjct: 170 SGTVTSVAVCP---PYAYTTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKPPAPPKKRPER 226 Query: 156 HCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 C R + QGH + L V S + + T AD R+ +++ Sbjct: 227 ICFAKADAR-----------KANDKTYQGHLKAPLVVKAS-QDGKFVVTGGADKRLVVYN 274 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 A T H V GL F L + D +++W+ Sbjct: 275 ----------------AADLKPIKAFTQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLD 318 Query: 276 NGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKG--- 332 + Y + + + + G T + V Q+ G Sbjct: 319 E-----LAYVETLFGHQDEILDIDALGQERCVSVGARDRTARYWKVPEESQLVFRGGGEG 373 Query: 333 --------------------HYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPV 369 H ++D + +GS + ++ W +P+ Sbjct: 374 GSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDD-DMFVTGSDNGDLALWSIQRKKPL 429 Score = 55.7 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 35/214 (16%), Positives = 65/214 (30%), Gaps = 39/214 (18%) Query: 20 RAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLS-GGSDGVIVLYDLENSSR 78 + T +V L+ + H I LDI+ + +S G D + + S+ Sbjct: 307 SKDRTVKVWSLDELAYVETLFGHQDEI--LDIDALGQERCVSVGARDRTARYWKVPEESQ 364 Query: 79 ----------QSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWD 128 S + H S++ V D MF + S + L +W Sbjct: 365 LVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAM--IDDDMFVTGSDNGDLALWS 422 Query: 129 TNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGS---CSHILQGH 185 + V + P ++L D + S I Sbjct: 423 IQRKKPLHVIARAHGLE--------------------PPIKLEDYSADEIPDPSIIPAPQ 462 Query: 186 RQEILAVSWSPRYDYILATASADSRVKLWDVRRA 219 + I A+ P D ++ + S D +++W + Sbjct: 463 PRGITALRTLPYSD-LIFSGSWDGCIRVWRLSED 495 >3JZG-A nrPDB Length = 402 Score = 82.7 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 49/322 (15%), Positives = 107/322 (33%), Gaps = 51/322 (15%) Query: 84 CKAVCSIGRDHPDVHRYSVETVQWYPH----DTGMFTSSSFDKTLKVWDTNTLQTADVFN 139 CK + H + VQ+ H D +F + ++ + +++ ++ + Sbjct: 39 CKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR-VTLYECHSQGEIRLLQ 97 Query: 140 FEETV-------YSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAV 192 +T H L+AV +++ + + C GH I + Sbjct: 98 SYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINEL 157 Query: 193 SWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLC 252 + PR +L + S D ++LW+++ + A+ H +V Sbjct: 158 KFHPRDPNLLLSVSKDHALRLWNIQTDT-------------LVAIFGGVEGHRDEVLSAD 204 Query: 253 FTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPY 312 + G +++ G D+ ++LW +N ++ N K+ + + Sbjct: 205 YDLLGEKIMSCGMDHSLKLW--------RINSKRMMNAIKESYDYNPNKTNRPFI----- 251 Query: 313 GSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVP-----SLYE 367 I + + H VDC + + S S + I+ W P + + Sbjct: 252 SQKIHFPDFSTRDI------HRNYVDCVRWL--GDLILSKSCENAIVCWKPGKMEDDIDK 303 Query: 368 PVPDDDETTTKSQLNPAFEDAW 389 P + T + + + D W Sbjct: 304 IKPSESNVTILGRFDYSQCDIW 325 Score = 72.3 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 39/283 (13%), Positives = 91/283 (32%), Gaps = 35/283 (12%) Query: 41 IHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRY 100 HG IN L P + +LS D + L++++ + + + + HR Sbjct: 149 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIF----------GGVEGHRD 198 Query: 101 SVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVA 160 V + + + S D +LK+W N+ + + S+ +P T ++ Sbjct: 199 EVLSADYDLLGEKIM-SCGMDHSLKLWRINSKRMMNAIK-----ESYDYNPNKTNRPFIS 252 Query: 161 VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRAS 220 K+ D + HR + V W ++ + S ++ + W + Sbjct: 253 -----QKIHFPDFSTRDI------HRNYVDCVRWLGD---LILSKSCENAIVCWKPGKME 298 Query: 221 GCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD--GLHLLTVGTDNRMRLWNSSNGE 278 + + + + + + F+ D L ++ +W+ + Sbjct: 299 DDIDKIKPSESNVTILGRFDYS--QCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED 356 Query: 279 NTLVN-YGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYT 320 + ++ T SS + V ++I + Sbjct: 357 PHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 399 Score = 68.8 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 44/308 (14%), Positives = 89/308 (28%), Gaps = 57/308 (18%) Query: 75 NSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQT 134 SR + H H ++ ++++P D + S S D L++W+ T Sbjct: 127 AGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTL 186 Query: 135 ADVFNFEETVYSHHMSPVSTKHCL----VAVGTRGPKVQLCDLKSGSCSHILQGHRQEIL 190 +F V H +S + L + ++L + S + ++ Sbjct: 187 VAIFGG---VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE------ 237 Query: 191 AVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNG 250 S D ++ + + I+ H S H V+ Sbjct: 238 ---------------SYD-----YNPNKTNRPFISQKIHFPDFSTRDI-----HRNYVDC 272 Query: 251 LCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS-CG------- 302 + + G +L+ +N + W E+ + +N +F S C Sbjct: 273 VRWL--GDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFS 330 Query: 303 ---CSSEFVFVPYGSTIAVYTVY----SGEQITMLKGHY--KTVDCCVFQSNFQELYSGS 353 + V+ + + T L H + F + L + Sbjct: 331 MDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVC 390 Query: 354 RDCNILAW 361 D +I W Sbjct: 391 DDASIWRW 398 >3I2N-A nrPDB Length = 357 Score = 81.1 bits (198), Expect = 7e-16, Method: Composition-based stats. Identities = 38/298 (12%), Positives = 95/298 (31%), Gaps = 29/298 (9%) Query: 99 RYSVETVQWYPHDTGMFTS----SSFDKTLKVWDTNTL--QTADVFNFEETVYSHHMSPV 152 Y+V +W P + F + + +++++ + + + Sbjct: 18 NYTVFDCKWVP-CSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFGAT 76 Query: 153 STKHCLVAVGTRGPKVQLCDLKSGS-CSHILQGHRQEILAVSWSPRYDYI-----LATAS 206 S + +A G G + + +L++ + ++GH++ I A+ + T S Sbjct: 77 SLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGS 136 Query: 207 ADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTD 266 D VK+WD R+ + ++ G+ + + + + + + + Sbjct: 137 RDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGN-------AYNQEERVVCAGYDN 189 Query: 267 NRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQ 326 ++L++ N + + N L+F ++ V V+ + + Sbjct: 190 GDIKLFDL---RNMALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHP 246 Query: 327 ITML-----KGHYKTVDCCVFQSNFQELY-SGSRDCNILAWVPSLYEPVPDDDETTTK 378 K H TV +EL+ + + W D + Sbjct: 247 TKGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIE 304 Score = 74.6 bits (181), Expect = 7e-14, Method: Composition-based stats. Identities = 38/274 (13%), Positives = 85/274 (31%), Gaps = 26/274 (9%) Query: 16 LRLRRAESTRRVLGLEL-NKDRDVERIHGGGINTLDIEPVEGRY-----MLSGGSDGVIV 69 L + LE + H IN +D G +++G DG + Sbjct: 83 LATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGTVK 142 Query: 70 LYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQW---YPHDTGMFTSSSFDKTLKV 126 ++D RQ + + ++ + TV + Y + + + + +K+ Sbjct: 143 VWD----PRQKDDPVANMEPVQGEN----KRDCWTVAFGNAYNQEERVVCAGYDNGDIKL 194 Query: 127 WDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHIL---- 182 +D + N + V S + + K + D+++ + Sbjct: 195 FDLRNMALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVS 254 Query: 183 -QGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGK---KSQAVE 238 + H+ + V P+ + TA + LW + S ++ Sbjct: 255 EKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLL 314 Query: 239 SANTAHNGKVNGLCFTSDGLHLLTVGT-DNRMRL 271 T ++ L ++ D L + D +R+ Sbjct: 315 QNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRV 348 Score = 70.3 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 47/368 (12%), Positives = 108/368 (29%), Gaps = 62/368 (16%) Query: 6 SARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDI--EPVEGRYMLSGG 63 SA+ + + R + +L R++E+ I ++ RY+ +G Sbjct: 30 SAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKA--KPIKCGTFGATSLQQRYLATGD 87 Query: 64 SDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKT 123 G + +++LE Y+ K I + + + S D T Sbjct: 88 FGGNLHIWNLEA-PEMPVYSVKGHKEIINAIDGIGGLGIGEGA------PEIVTGSRDGT 140 Query: 124 LKVWD-------TNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSG 176 +KVWD ++ N + + + + +V G ++L DL++ Sbjct: 141 VKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNM 200 Query: 177 SCSHILQGHRQEILAVSWSPRYDYI--LATASADSRVKLWDVRRASGCLITLDQHNGKKS 234 + + ++ + + + L S + + ++D+R Sbjct: 201 -ALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRT-----------QHPTK 248 Query: 235 QAVESANTAHNGKVNGLCFTS-DGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKK 293 + AH V + + LT G + LW + + Sbjct: 249 GFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYE-------YPIQRSKKDSE 301 Query: 294 GLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGS 353 G++ V+ S + + + + + + + L S Sbjct: 302 GIEMGVAGSVS---------------------LLQNVTLSTQPISSLDWSPDKRGLCVCS 340 Query: 354 R-DCNILA 360 D + Sbjct: 341 SFDQTVRV 348 >6BX3-B nrPDB Length = 412 Score = 80.3 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 67/359 (18%), Positives = 128/359 (35%), Gaps = 35/359 (9%) Query: 46 INTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETV 105 L P G Y+ G ++G +V+YD++ T + +C G H + ++ Sbjct: 28 TECLQFSPC-GDYLALGCANGALVIYDMD--------TFRPICVPGNMLG-AHVRPITSI 77 Query: 106 QWYPHDTGMFTSSSFDKTLKVWDTNT-LQTADVFNFEETVYSHHMSPVSTKHCLVAVGTR 164 W P D + +SS D ++K+WD + + F+ ++ + C VA Sbjct: 78 AWSP-DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLC-VATIFE 135 Query: 165 GPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLI 224 + D S L E +S +P + Y+L + V + G L Sbjct: 136 ESDAYVIDF-SNDPVASLLSKSDE-KQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLD 193 Query: 225 TLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS-NGENTLVN 283 H+ +++ + S + + L + +G L +D +R + S + EN+ V Sbjct: 194 FYKFHSLYQTECIHSLKITSSN-IKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVE 252 Query: 284 YGKVCNNSKKGLKFTVSC-----GCSSEFVFVPYGSTIA---VYTVYSGEQITMLKGHYK 335 K +C + V +GS+ ++ SG + +L+G + Sbjct: 253 LTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEE 312 Query: 336 TVDCCVFQSNFQELYS-GSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSD 393 + + + S G N+ W + S L P FE+ + D Sbjct: 313 ELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKW---------SALAPDFEEVEENVD 362 Score = 70.3 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 50/336 (14%), Positives = 106/336 (31%), Gaps = 28/336 (8%) Query: 14 DPLRLRRAESTRRVLGLELNKDRDVER----IHGGGINTLDIEPVEGRYMLSGGSDGVIV 69 D L L A + ++ + V H I ++ P +GR +L+ D I Sbjct: 38 DYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP-DGRLLLTSSRDWSIK 96 Query: 70 LYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDT 129 L+DL S+ G D R + S D + Sbjct: 97 LWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFE-ESDAYVIDFSNDPVASL--L 153 Query: 130 NTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGP---KVQLCDLKSGSCSHILQGHR 186 + + + + Y + + ++ VGT + L C H L+ Sbjct: 154 SKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITS 213 Query: 187 QEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNG 246 I + S + + S D ++ +++ K + Sbjct: 214 SNIKHLIVSQNGERLAINCS-DRTIRQYEISIDDENSAVELTLEHKYQDVINKLQW---- 268 Query: 247 KVNGLCFTSDG-LHLLT---VGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCG 302 N + F+++ +L+ + + + +W +++G V G +++ L Sbjct: 269 --NCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEG-----AEEELIDINWDF 321 Query: 303 CSSEFVFVPYGST-IAVYTVYSGEQITMLKGHYKTV 337 S V + S + V++V + + L ++ V Sbjct: 322 YSMSIVSNGFESGNVYVWSVVIPPKWSALAPDFEEV 357 Score = 60.7 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 42/264 (15%), Positives = 77/264 (29%), Gaps = 26/264 (9%) Query: 133 QTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHI----LQGHRQE 188 + SP +A+G + + D+ + + L H + Sbjct: 17 KLTHTIENPLRTECLQFSPCGD---YLALGCANGALVIYDMDTFRPICVPGNMLGAHVRP 73 Query: 189 ILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKV 248 I +++WSP +L + S D +K + S L + A Sbjct: 74 ITSIAWSPDGRLLLTS-SRDWSIK---LWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLC 129 Query: 249 NGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVN----YGKVCNNSKKGLKFTVSCGCS 304 F +++ D L + S+ + Y VC K + Sbjct: 130 VATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSK 189 Query: 305 SEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPS 364 F +++Y E I LK + + N + L D I Sbjct: 190 GWLDFY------KFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIR----- 238 Query: 365 LYEPVPDDDETTTKSQLNPAFEDA 388 YE DD+ + + L ++D Sbjct: 239 QYEISIDDENSAVELTLEHKYQDV 262 >5YZG-2 nrPDB Length = 646 Score = 79.6 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 37/273 (13%), Positives = 85/273 (31%), Gaps = 40/273 (14%) Query: 29 GLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVC 88 L + +H I + + ++++ DG + + + ++ Sbjct: 76 NLPSASMYERSYMHRDVITHVVCTKTD--FIITASHDGHVKFWKKIEEGIEFVKHFRS-- 131 Query: 89 SIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNT-------------LQTA 135 H +E++ +F S DK +KV+D Q Sbjct: 132 ---------HLGVIESIAVSSEG-ALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCE 181 Query: 136 DVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHIL-QGHRQEILAVSW 194 ++ + + S S ST + G HI + H + + Sbjct: 182 WIYCPGDAISSVAASEKSTGKIFIYDGRGDN----------QPLHIFDKLHTSPLTQIRL 231 Query: 195 SPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFT 254 +P Y ++++ ++ W + + K+ +CF+ Sbjct: 232 NPVYKAVVSS-DKSGMIEYW-TGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFS 289 Query: 255 SDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKV 287 DG + T+G+D ++R++ G+ V + Sbjct: 290 PDGKKIATIGSDRKVRIFRFVTGKLMRVFDESL 322 Score = 58.0 bits (138), Expect = 8e-09, Method: Composition-based stats. Identities = 24/262 (9%), Positives = 71/262 (27%), Gaps = 30/262 (11%) Query: 128 DTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCD-LKSG-SCSHILQGH 185 + + + V +H V TK + + V+ ++ G + H Sbjct: 76 NLPSASMYERSYMHRDVITH---VVCTKTDFIITASHDGHVKFWKKIEEGIEFVKHFRSH 132 Query: 186 RQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHN 245 I +++ S + + D +K++DV ++ Sbjct: 133 LGVIESIAVSSEGA-LFCSVGDDKAMKVFDV----VNFDMINMLKLGYFPGQCEWIYCPG 187 Query: 246 GKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGL------KFTV 299 ++ + + ++ +++ L + K+ + + K V Sbjct: 188 DAISSVAASEKST--------GKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVV 239 Query: 300 SCGCSSEFVFVPYGSTIAV------YTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGS 353 S S + + + + F + +++ + Sbjct: 240 SSDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIG 299 Query: 354 RDCNILAWVPSLYEPVPDDDET 375 D + + + + DE+ Sbjct: 300 SDRKVRIFRFVTGKLMRVFDES 321 >4J0X-A nrPDB Length = 451 Score = 77.7 bits (189), Expect = 9e-15, Method: Composition-based stats. Identities = 46/341 (13%), Positives = 94/341 (27%), Gaps = 45/341 (13%) Query: 52 EPVEGRYML-SGGSDGVIVLYDLENSSRQSYYTCKA---------VCSIGRDHPDVHRYS 101 + +GR + D + YD+ + S++ A + + H Sbjct: 57 DKNKGRLFAYTVSKDLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSKHEYENTTEGHYDE 116 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 + TV P D + D+ L VW T +L V ++ + Sbjct: 117 ILTVAASP-DGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYA 175 Query: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASG 221 K++ + S IL GH + +S + + D LW + + Sbjct: 176 SCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMER-CVTVGARDRTAMLWKIPDETR 234 Query: 222 CLITLDQHNGKKSQ--AVESANTAHNGKVN----------------GLCFTSDGLHLLTV 263 K + E+A +G+V + D H +T Sbjct: 235 LTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMVDDFHFITG 294 Query: 264 GTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYS 323 + + LW+ + + + ++ + F G + + Sbjct: 295 SDNGNICLWSLA--KKKPIFTERIAHGILPEPSFNDISGE--------TDEELRKRQLQG 344 Query: 324 GEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPS 364 + + + SGS ++ W S Sbjct: 345 KKLLQPF-----WITSLYAIPYSNVFISGSWSGSLKVWKIS 380 Score = 66.1 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 43/255 (16%), Positives = 78/255 (30%), Gaps = 59/255 (23%) Query: 177 SCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQA 236 + +GH EIL V+ SP Y++ T D ++ +W S + + Sbjct: 105 EYENTTEGHYDEILTVAASPDGKYVV-TGGRDRKLIVWSTESLSPVKVIPTKDR------ 157 Query: 237 VESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLK 296 G+V L F + L D ++R ++ + + YG ++ Sbjct: 158 --------RGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGH-----HDIVE 204 Query: 297 FTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHY---------------------- 334 + T ++ + ++T G Sbjct: 205 DISALAMERCVTVGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVK 264 Query: 335 -------------KTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQL 381 ++D +F + +GS + NI W SL + P E L Sbjct: 265 YPDESEAPLFFCEGSIDVVSMVDDFHFI-TGSDNGNICLW--SLAKKKPIFTERIAHGIL 321 Query: 382 -NPAFEDAWSSSDEE 395 P+F D +DEE Sbjct: 322 PEPSFNDISGETDEE 336 Score = 42.2 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 18/108 (16%), Positives = 39/108 (36%), Gaps = 12/108 (11%) Query: 262 TVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTV 321 + G N+ RL+ + ++ + + + SK+ K + G + + Sbjct: 54 SNGDKNKGRLFAYTVSKDLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSKH--------- 104 Query: 322 YSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPV 369 E +GHY + + + + +G RD ++ W PV Sbjct: 105 ---EYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPV 149 Score = 39.9 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 26/171 (15%), Positives = 55/171 (32%), Gaps = 36/171 (21%) Query: 54 VEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG 113 V+ + ++G +G I L+ L K + + H + S Sbjct: 286 VDDFHFITGSDNGNICLWSLAK--------KKPIFTERIAHGILPEPSFND--------- 328 Query: 114 MFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLC-- 171 S D+ L+ + F + S + P S + G+ +++ Sbjct: 329 --ISGETDEELRKRQLQGKKLLQPF----WITSLYAIPYS---NVFISGSWSGSLKVWKI 379 Query: 172 --DLKSGSCSHILQGHRQEILAVSWSPRYDY------ILATASADSRVKLW 214 +L+S L G + + + + ILA+ + + R+ W Sbjct: 380 SDNLRSFELLGELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRLGRW 430 >5WLC-SG nrPDB Length = 573 Score = 77.3 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 46/341 (13%), Positives = 94/341 (27%), Gaps = 45/341 (13%) Query: 52 EPVEGRYML-SGGSDGVIVLYDLENSSRQSYYTCKA---------VCSIGRDHPDVHRYS 101 + +GR + D + YD+ + S++ A + + H Sbjct: 179 DKNKGRLFAYTVSKDLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSKHEYENTTEGHYDE 238 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 + TV P D + D+ L VW T +L V ++ + Sbjct: 239 ILTVAASP-DGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYA 297 Query: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASG 221 K++ + S IL GH + +S + + D LW + + Sbjct: 298 SCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMER-CVTVGARDRTAMLWKIPDETR 356 Query: 222 CLITLDQHNGKKSQ--AVESANTAHNGKVN----------------GLCFTSDGLHLLTV 263 K + E+A +G+V + D H +T Sbjct: 357 LTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMVDDFHFITG 416 Query: 264 GTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYS 323 + + LW+ + + + ++ + F G + + Sbjct: 417 SDNGNICLWSLA--KKKPIFTERIAHGILPEPSFNDISGE--------TDEELRKRQLQG 466 Query: 324 GEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPS 364 + + + SGS ++ W S Sbjct: 467 KKLLQPF-----WITSLYAIPYSNVFISGSWSGSLKVWKIS 502 Score = 65.7 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 43/255 (16%), Positives = 78/255 (30%), Gaps = 59/255 (23%) Query: 177 SCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQA 236 + +GH EIL V+ SP Y++ T D ++ +W S + + Sbjct: 227 EYENTTEGHYDEILTVAASPDGKYVV-TGGRDRKLIVWSTESLSPVKVIPTKDR------ 279 Query: 237 VESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLK 296 G+V L F + L D ++R ++ + + YG ++ Sbjct: 280 --------RGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGH-----HDIVE 326 Query: 297 FTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHY---------------------- 334 + T ++ + ++T G Sbjct: 327 DISALAMERCVTVGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVK 386 Query: 335 -------------KTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQL 381 ++D +F + +GS + NI W SL + P E L Sbjct: 387 YPDESEAPLFFCEGSIDVVSMVDDFHFI-TGSDNGNICLW--SLAKKKPIFTERIAHGIL 443 Query: 382 -NPAFEDAWSSSDEE 395 P+F D +DEE Sbjct: 444 PEPSFNDISGETDEE 458 Score = 42.2 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 18/108 (16%), Positives = 39/108 (36%), Gaps = 12/108 (11%) Query: 262 TVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTV 321 + G N+ RL+ + ++ + + + SK+ K + G + + Sbjct: 176 SNGDKNKGRLFAYTVSKDLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSKH--------- 226 Query: 322 YSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPV 369 E +GHY + + + + +G RD ++ W PV Sbjct: 227 ---EYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPV 271 Score = 39.5 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 26/171 (15%), Positives = 55/171 (32%), Gaps = 36/171 (21%) Query: 54 VEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG 113 V+ + ++G +G I L+ L K + + H + S Sbjct: 408 VDDFHFITGSDNGNICLWSLAK--------KKPIFTERIAHGILPEPSFND--------- 450 Query: 114 MFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLC-- 171 S D+ L+ + F + S + P S + G+ +++ Sbjct: 451 --ISGETDEELRKRQLQGKKLLQPF----WITSLYAIPYS---NVFISGSWSGSLKVWKI 501 Query: 172 --DLKSGSCSHILQGHRQEILAVSWSPRYDY------ILATASADSRVKLW 214 +L+S L G + + + + ILA+ + + R+ W Sbjct: 502 SDNLRSFELLGELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRLGRW 552 >5WLC-LN nrPDB Length = 776 Score = 76.5 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 33/269 (12%), Positives = 80/269 (29%), Gaps = 25/269 (9%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTL---QTADVFNFEETVYSHHMSPVST 154 H+ ++ + P D + +++W+ + + ++ S V+ Sbjct: 53 HKSNIN--KLTPSD-LRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCWSNVNG 109 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLW 214 + + V DL +G + I ++S + D L+ + V L Sbjct: 110 ESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQDK-LSVGCDNGTVVLI 168 Query: 215 DVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 D+ G ++ +V L + D ++ +D R+R+W++ Sbjct: 169 DISG------------GPGVLEHDTILMRQEARVLTLAWKKDD-FVIGGCSDGRIRIWSA 215 Query: 275 SNGENTLVNYGKV-----CNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITM 329 + + + + + + +I + Sbjct: 216 QKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQS 275 Query: 330 LKGHYKTVDCCVFQSNFQELYSGSRDCNI 358 K H V C ++ ++S D I Sbjct: 276 FKAHDADVLCLTTDTDNNYVFSAGVDRKI 304 Score = 69.6 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 52/385 (13%), Positives = 117/385 (30%), Gaps = 73/385 (18%) Query: 28 LGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAV 87 L + G I ++ I + + + G +G +VL D+ + + Sbjct: 126 WDLATGLPLRNYDCNSGVIWSISINDSQDKLSV-GCDNGTVVLIDISGGPGVLEHDTILM 184 Query: 88 CSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWD-----------TNTLQTAD 136 R V T+ W D +++W +T++ Sbjct: 185 RQEAR---------VLTLAW--KKDDFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDK 233 Query: 137 VFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSP 196 V+S P + + +A G ++ D + + + + H ++L ++ Sbjct: 234 AKKESTLVWSVIYLPRTDQ---IASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDT 290 Query: 197 RYDYILATASADSRVKLWDVRRA-----------------SGCLITLDQHNGKKSQAVES 239 +Y+ +A D ++ + + + + K + + S Sbjct: 291 DNNYVF-SAGVDRKIFQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVS 349 Query: 240 ANTAHNGKVNGLCFTSDG--------------------LHLLTVGTDNRMRLWNSSNGEN 279 +N L S+G L+ +++ +++W + Sbjct: 350 GGVEKTLVINSLTSFSNGNYRKMPTVEPYSKNVLVNKEQRLVVSWSESTVKIWTMGTDSS 409 Query: 280 TLVNYGKVCNNSKKGLKFTVSC--GCSSEFVFVPYGSTIAVYTVY---SGEQITMLKGHY 334 T NY VC + K + +C + + V ST V+ + + ++T L Sbjct: 410 TEQNYKLVCKLTLKDDQNISTCSLSPDGQVLVVGRPSTTKVFHLQPVGNKLKVTKLDNDL 469 Query: 335 KTVDC---CVFQSNFQ-ELYSGSRD 355 F N + + S D Sbjct: 470 LLRTSTKLVKFIDNSKIVICSCEDD 494 Score = 67.6 bits (163), Expect = 9e-12, Method: Composition-based stats. Identities = 59/418 (14%), Positives = 132/418 (31%), Gaps = 78/418 (18%) Query: 18 LRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSS 77 R R + + H IN + P + + G S+G I +++ N+ Sbjct: 29 ERMIVHRCRFVDFTPATITSLAFSHKSNIN--KLTPSD-LRLAIGRSNGNIEIWNPRNN- 84 Query: 78 RQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG--MFTSSSFDKTLKVWDTNTLQTA 135 + + V G+D S+E + W + S + WD T Sbjct: 85 ----WFQEMVIEGGKD------RSIEGLCWSNVNGESLRLFSIGGSTVVTEWDLATGLPL 134 Query: 136 DVFNFEE-TVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSG----SCSHILQGHRQEIL 190 ++ ++S ++ K ++VG V L D+ G IL +L Sbjct: 135 RNYDCNSGVIWSISINDSQDK---LSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVL 191 Query: 191 AVSWSPRYDYILATASADSRVKLWDVRRASGCL--------------------------I 224 ++W + +D R+++W ++ + Sbjct: 192 TLAWKKDD--FVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPR 249 Query: 225 TLDQHNGKKSQAVESANT----------AHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 T +G + +++ + AH+ V L +D ++ + G D ++ ++ Sbjct: 250 TDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQ 309 Query: 275 SNGENTLVNY------GKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSG---- 324 + ++ N + N + + S G + V T+ + ++ S Sbjct: 310 NTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKG-ADFLVSGGVEKTLVINSLTSFSNGN 368 Query: 325 -EQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQL 381 ++ ++ + K V + Q L + + W + + K L Sbjct: 369 YRKMPTVEPYSKNV----LVNKEQRLVVSWSESTVKIWTMGTDSSTEQNYKLVCKLTL 422 >6CHG-D nrPDB Length = 439 Score = 75.7 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 61/370 (16%), Positives = 124/370 (33%), Gaps = 54/370 (14%) Query: 48 TLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQW 107 + P G Y+ G S+G I++YD+++ K + +G H H SV++V W Sbjct: 32 CVKFSP-RGDYLAVGCSNGAIIIYDMDS--------LKPIAMLG-THSGAHTRSVQSVCW 81 Query: 108 YPHDTGMFTSSSFDKTLKVWDTNT-LQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGP 166 +D SS D K+WD + + F+ ++S H+ + V Sbjct: 82 S-NDGRYLWSSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWNVCIVTVVEEPTAY 140 Query: 167 KVQLCDLKS-------GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRA 219 + L D ++ + GH L P + I+ T ++ + + + Sbjct: 141 VLTLTDRQNAFHCFPLLEQDQDISGH-GYTLVACPHPTIESIIITGTSKGWINAFQLD-- 197 Query: 220 SGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS----- 274 L+ K + A N + + + G + G+D +R + Sbjct: 198 ------LESGFEDKIRCCYEEKIA-NANIKQIIISPSGTRIAINGSDRTIRQYQLIVEDN 250 Query: 275 ----SNGENTLVNYGKVCNNSKKGLKFTVSCGCSS---EFVFVPYGSTIA---VYTVYSG 324 + + + + L++ + V +GS+ ++ SG Sbjct: 251 ESEGGSSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSSG 310 Query: 325 EQITMLKGHYKTVDCCVFQSNFQELYS-GSRDCNILAWVPSLYEPVPDDDETTTKSQLNP 383 + +L+G + + + + S G + W + S L P Sbjct: 311 SLVRVLEGADEELLDIDWNFYSMRIASNGFESGWVYMWSIVIPPKW---------SALAP 361 Query: 384 AFEDAWSSSD 393 FE+ + D Sbjct: 362 DFEEVEENID 371 Score = 56.5 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 40/309 (12%), Positives = 84/309 (27%), Gaps = 66/309 (21%) Query: 153 STKHCLVAVGTRGPKVQLCDLKSGSCSHIL----QGHRQEILAVSWSPRYDYILATASAD 208 S + +AVG + + D+ S +L H + + +V WS Y+ ++ D Sbjct: 36 SPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSNDGRYLWSSG-RD 94 Query: 209 SRVKLWDVRRASGCLITLDQHNGKKSQAVESAN--------------------------- 241 KLWD+ + + C S V N Sbjct: 95 WYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWNVCIVTVVEEPTAYVLTLTDRQNAFHCF 154 Query: 242 ---------TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLW--NSSNGENTLVNYGKVCNN 290 + H + + ++T + + + + +G + Sbjct: 155 PLLEQDQDISGHGYTLVACPHPTIESIIITGTSKGWINAFQLDLESGFEDKIRCCYEEKI 214 Query: 291 SKKGLKFTVSCGCSSEFVFVPYGSTIAVYTV-----------YSGEQITMLKGHYKTVDC 339 + +K + + TI Y + I + + ++ Sbjct: 215 ANANIKQIIISPSGTRIAINGSDRTIRQYQLIVEDNESEGGSSHSVSIELEHKYQDIINR 274 Query: 340 CVFQS------NFQELYS---GSRDCNILAWVPSLY---EPVPDDDETTTKSQLNPAFED 387 + + + + L + GS ++ W S + DE N Sbjct: 275 LQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSSGSLVRVLEGADEELLDIDWNFYSMR 334 Query: 388 AWSSSDEEG 396 S+ E G Sbjct: 335 IASNGFESG 343 Score = 48.4 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 51/320 (15%), Positives = 104/320 (32%), Gaps = 47/320 (14%) Query: 41 IHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRY 100 H + ++ +GRY+ S G D L+D+ + + K + H Sbjct: 71 AHTRSVQSVCWS-NDGRYLWSSGRDWYAKLWDM-TQPTKCFQQYKFDGPLWSCHVVRWNV 128 Query: 101 SVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKH---- 156 + TV P + + N + ++ + H + V+ H Sbjct: 129 CIVTVVEEPTAYVLTLTDRQ---------NAFHCFPLLEQDQDISGHGYTLVACPHPTIE 179 Query: 157 CLVAVGTRGPKVQLC--DLKSG-----SCSHILQGHRQEILAVSWSPRYDYILATASADS 209 ++ GT + DL+SG C + + I + SP I S D Sbjct: 180 SIIITGTSKGWINAFQLDLESGFEDKIRCCYEEKIANANIKQIIISPSGTRIAINGS-DR 238 Query: 210 RVKLWDVRRASGCLITLDQHNGKKSQAVESANTAH--NGKVNGLCFTS------DGLHLL 261 ++ + + I D + S S H +N L + + G +L+ Sbjct: 239 TIRQYQL-------IVEDNESEGGSSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLV 291 Query: 262 T---VGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGST-IA 317 + + + LW +S+G V G + + L S + S + Sbjct: 292 ASAHGSSAHDLYLWETSSGSLVRVLEG-----ADEELLDIDWNFYSMRIASNGFESGWVY 346 Query: 318 VYTVYSGEQITMLKGHYKTV 337 ++++ + + L ++ V Sbjct: 347 MWSIVIPPKWSALAPDFEEV 366 Score = 38.4 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 35/224 (15%), Positives = 70/224 (31%), Gaps = 30/224 (13%) Query: 13 EDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLY- 71 L + L + HG + P +++G S G I + Sbjct: 137 PTAYVLTLTDRQNAFHCFPLLEQDQDISGHGYTLVACP-HPTIESIIITGTSKGWINAFQ 195 Query: 72 -DLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN 130 DLE+ C + +++ + P T + + S D+T++ + Sbjct: 196 LDLESGFEDKIRCCYE--------EKIANANIKQIIISPSGTRIAINGS-DRTIRQYQLI 246 Query: 131 TLQTADVFNFEETV----------------YSHHMSPVSTKHCLVAV--GTRGPKVQLCD 172 +V ++ + LVA G+ + L + Sbjct: 247 VEDNESEGGSSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWE 306 Query: 173 LKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 SGS +L+G +E+L + W+ I + V +W + Sbjct: 307 TSSGSLVRVLEGADEELLDIDWNFYSMRIASNGFESGWVYMWSI 350 >5CXB-B nrPDB Length = 369 Score = 75.0 bits (182), Expect = 6e-14, Method: Composition-based stats. Identities = 50/387 (12%), Positives = 102/387 (26%), Gaps = 97/387 (25%) Query: 38 VERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDV 97 + R H G + ++ I+P G + +GG DG + +++L + Sbjct: 16 IFRGHEGRVRSVAIDPT-GVALATGGDDGTVRVWELLTGRQVWSVKLNG----------- 63 Query: 98 HRYSVETVQWYPHDTGMF--TSSSFDKTLKV----------------------WDTNTLQ 133 +V TV+W P ++ D L + + Sbjct: 64 -DEAVNTVRWRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGK 122 Query: 134 TADVFNFEETVYSHHMSP---VSTKHCLVAV--------------GTRGPKVQLCDLKSG 176 + P + + L+ + G V +S Sbjct: 123 QQANLPPGKEPPGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRSS 182 Query: 177 SCSHILQGHRQEI---------LAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLD 227 H L H +I S+ P + ++ +D+++ I Sbjct: 183 VAIHTLSKHLTQIPFRKLNGLAQTASFHPLRPLFFV--ATQRSIRCYDLQKLELVKIVQP 240 Query: 228 QHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKV 287 ++ G +L+ D R+ LW+ + N + Sbjct: 241 G----------------AKWISSFDVHPGGDNLVVGSYDKRL-LWHDLDLSNRPYKTMRF 283 Query: 288 CNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVY---------TVYSGEQITMLKGHYKT-- 336 + + ++F G F ++ ++ + + MLKGH Sbjct: 284 HTEAIRAVRF--HKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNK 341 Query: 337 --VDCCVFQSNFQELYSGSRDCNILAW 361 V + S D W Sbjct: 342 LGVLDIDWHPREPWCVSAGADGTARLW 368 Score = 66.5 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 42/287 (14%), Positives = 79/287 (27%), Gaps = 21/287 (7%) Query: 79 QSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADV- 137 S K ++ + H V +V P + D T++VW+ T + Sbjct: 1 PSPDELKPFPTVQQTIFRGHEGRVRSVAIDPTGVA-LATGGDDGTVRVWELLTGRQVWSV 59 Query: 138 -FNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSW-S 195 N +E V + P L A + + S + L ++IL + Sbjct: 60 KLNGDEAVNTVRWRPTKDTFILAAAAGEDIFLMI--PTHPSVTPALDQASRDILNAGFGH 117 Query: 196 PRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS 255 A ++ + + + + + Sbjct: 118 ATNGKQQA-----------NLPPGKEPPGKWARPGTRLEDEGVLLRITVRSTIKAISWHR 166 Query: 256 DGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGST 315 G H TV + +S + ++ GL T S FV + Sbjct: 167 RGDHFATVSPSGQR---SSVAIHTLSKHLTQIPFRKLNGLAQTASFHPLRPLFFVATQRS 223 Query: 316 IAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWV 362 I Y + E + +++ K + L GS D + W Sbjct: 224 IRCYDLQKLELVKIVQPGAKWISSFDVHPGGDNLVVGSYDKRL-LWH 269 Score = 53.4 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 20/115 (17%), Positives = 40/115 (34%), Gaps = 2/115 (1%) Query: 14 DPLRLRRAESTRRVLGLEL-NKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYD 72 D L + + L+L N+ R H I + DG + ++ Sbjct: 255 DNLVVGSYDKRLLWHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFH 314 Query: 73 LENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVW 127 + + Q + + H V++ V + W+P + S+ D T ++W Sbjct: 315 GKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWC-VSAGADGTARLW 368 Score = 52.6 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 18/168 (10%), Positives = 51/168 (30%), Gaps = 24/168 (14%) Query: 15 PLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLE 74 PL + + R L+ + + + I++ D+ P ++ G D Sbjct: 214 PLFFVATQRSIRCYDLQKLELVKIVQPGAKWISSFDVHPGGDNLVV-GSYDK-------- 264 Query: 75 NSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN---- 130 + + + + H ++ V+++ +F +S D +L+++ Sbjct: 265 ----RLLWHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKVPND 320 Query: 131 -----TLQTADVFNFEETVYSHHMSPVS--TKHCLVAVGTRGPKVQLC 171 T+ + + V + + + +L Sbjct: 321 QLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWCVSAGADGTARLW 368 Score = 43.8 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 9/42 (21%), Positives = 13/42 (30%) Query: 328 TMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPV 369 T+ +GH V L +G D + W V Sbjct: 15 TIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQV 56 >2P9P-C nrPDB Length = 372 Score = 74.6 bits (181), Expect = 7e-14, Method: Composition-based stats. Identities = 36/238 (15%), Positives = 81/238 (34%), Gaps = 20/238 (8%) Query: 45 GINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVET 104 I+ + + ++ + +Y+ + + K H V Sbjct: 10 PISCHAWN-KDRTQIAICPNNHEVHIYEKSGNKWVQVHELK-----------EHNGQVTG 57 Query: 105 VQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTR 164 V W P D+ + D+ VW + + AVG+ Sbjct: 58 VDWAP-DSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSG 116 Query: 165 GPKVQLCDLK----SGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD--VRR 218 + +C + C HI + R +L++ W P +LA S D + +++ ++ Sbjct: 117 SRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHP-NSVLLAAGSCDFKCRIFSAYIKE 175 Query: 219 ASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN 276 + + +++ G V+G+CF+++G + V D+ + L ++ Sbjct: 176 VEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADK 233 Score = 53.8 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 38/243 (15%), Positives = 69/243 (28%), Gaps = 44/243 (18%) Query: 140 FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGS--CSHILQGHRQEILAVSWSPR 197 V + +A+ +V + + H L+ H ++ V W+P Sbjct: 4 HSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPD 63 Query: 198 YDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDG 257 + I+ T D +W TL K + + N A + + + Sbjct: 64 SNRIV-TCGTDRNAYVW----------TLKGRTWKPTLVILRINRAA----RCVRWAPNE 108 Query: 258 LHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTV-SCGCSSEFVFVPYGS-- 314 + + EN VC + KK ++ TV S V + GS Sbjct: 109 KKFAVGSGSRVISI-CYFEQENDW----WVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCD 163 Query: 315 -TIAVYTVYS------------------GEQITMLKGHYKTVDCCVFQSNFQELYSGSRD 355 +++ Y GE + V F +N + S D Sbjct: 164 FKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHD 223 Query: 356 CNI 358 + Sbjct: 224 STV 226 Score = 51.8 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 33/213 (15%), Positives = 62/213 (29%), Gaps = 23/213 (10%) Query: 188 EILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGK 247 I +W+ +A + V +++ + + HNG+ Sbjct: 10 PISCHAWNKD-RTQIAICPNNHEVHIYEKSGNKWVQVHELKE--------------HNGQ 54 Query: 248 VNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEF 307 V G+ + D ++T GTD +W + V + + +F Sbjct: 55 VTGVDWAPDSNRIVTCGTDRNAYVW---TLKGRTWKPTLVILRINRAARCVRWAPNEKKF 111 Query: 308 VFVPYGSTIAVYTVYSGE----QITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVP 363 I++ + K TV + N L +GS D + Sbjct: 112 AVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSA 171 Query: 364 SLYEPVPDDDETTTKSQLNPAFEDAWSSSDEEG 396 + E T S++ E + SS G Sbjct: 172 YIKEVEERPAPTPWGSKMPFG-ELMFESSSSCG 203 Score = 46.8 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 49/343 (14%), Positives = 95/343 (27%), Gaps = 86/343 (25%) Query: 22 ESTRRVLGLELNKDRDVERI--HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQ 79 + NK V + H G + +D P + +++ G+D ++ L+ + + Sbjct: 29 NHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAP-DSNRIVTCGTDRNAYVWTLKGRTWK 87 Query: 80 SYYTCKAVCSIGR------------------------------DHPDVH-----RYSVET 104 + R H R +V + Sbjct: 88 PTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLS 147 Query: 105 VQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADV----------------FNFEETVYSHH 148 + W+P ++ + + S D +++ + + F + H Sbjct: 148 LDWHP-NSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVH 206 Query: 149 MSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASAD 208 S VA + V L D L +LAV++ L A D Sbjct: 207 GVCFSANGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLAVTFITESS--LVAAGHD 264 Query: 209 SRVKLWDVRRASGCLITLDQHNGKKSQAVESA-------------------------NTA 243 L+ A+G L + + K + ++ Sbjct: 265 CFPVLFTYDSAAGKLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGSAAAGAGLDSL 324 Query: 244 HNGKVNGLCFTSDG----LHLLTVGTDNRMRLWNSSNGENTLV 282 H V+ + S G T G D M +W+ + E+ L Sbjct: 325 HKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVRSLESALK 367 Score = 43.8 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 10/86 (11%), Positives = 23/86 (26%), Gaps = 2/86 (2%) Query: 287 VCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQIT--MLKGHYKTVDCCVFQS 344 + + + ++ P + +Y + + LK H V + Sbjct: 3 YHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAP 62 Query: 345 NFQELYSGSRDCNILAWVPSLYEPVP 370 + + + D N W P Sbjct: 63 DSNRIVTCGTDRNAYVWTLKGRTWKP 88 >6E29-D nrPDB Length = 345 Score = 74.2 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 54/355 (15%), Positives = 106/355 (29%), Gaps = 49/355 (13%) Query: 34 KDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRD 93 + I G + +G ++ SG DG +V++DLE Sbjct: 16 PENITNTIRSGHSTCVRFN-RKGDFLASGRVDGTVVIWDLETMGVARKLRG--------- 65 Query: 94 HPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVS 153 H ++ ++ W S+ + +WD + F VY + P Sbjct: 66 ----HSKNITSLSWS-RCGRYLLSACQGWKVILWDLQDGKRYREVRFRAPVYGAELHP-- 118 Query: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSP-------------RYDY 200 H A + L D+ + + + P Sbjct: 119 WNHHQFAAALFEDQPMLVDITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTA 178 Query: 201 ILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHL 260 I+ TAS D + A L+ + + + + S A +G + L T G L Sbjct: 179 IVYTASGDHLL-------AGTTKGRLNIIDARTREIIYSEKIA-SGIITTLRLTESGREL 230 Query: 261 LTVGTDNRMRLWNSSN-------GENTLVNYGKVCNNSKKGLKFT-VSCGCSSEFVFVPY 312 L D +R + N + + + L + V+ + E+V Sbjct: 231 LVNAQDRIIRTFIVPNLSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAAST 290 Query: 313 GST--IAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRD-CNILAWVPS 364 + + ++ G + ML+G + + + L + + I W + Sbjct: 291 YNNHELYIWERGHGSLVRMLEGPKEEQGVIEWHPHRALLAACGLETGRINIWSVT 345 Score = 67.6 bits (163), Expect = 9e-12, Method: Composition-based stats. Identities = 41/247 (16%), Positives = 80/247 (32%), Gaps = 13/247 (5%) Query: 148 HMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASA 207 + K +A G V + DL++ + L+GH + I ++SWS Y+L +A Sbjct: 29 TCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRYLL-SACQ 87 Query: 208 DSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDN 267 +V LWD++ + ++ + H D L+ + Sbjct: 88 GWKVILWDLQDGKRYREVRFRAPVYGAELHPWNH--HQ---FAAALFEDQPMLVDITEPV 142 Query: 268 RMR-----LWNSSNGENTLVNYGKVCNNSKKGL-KFTVSCGCSSEFVFVPYGSTIAVYTV 321 +R + ++ E K K + V + + + Sbjct: 143 EVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNIIDA 202 Query: 322 YSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQL 381 + E I K + + +EL ++D I ++ D D T + L Sbjct: 203 RTREIIYSEKIASGIITTLRLTESGRELLVNAQDRIIRTFIVP-NLSAADLDPDTIQLPL 261 Query: 382 NPAFEDA 388 F+D Sbjct: 262 EHKFQDV 268 Score = 61.9 bits (148), Expect = 5e-10, Method: Composition-based stats. Identities = 47/325 (14%), Positives = 104/325 (32%), Gaps = 21/325 (6%) Query: 8 RQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGV 67 R D L R + T + LE R H I +L GRY+LS Sbjct: 32 RFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRC-GRYLLSACQGWK 90 Query: 68 IVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLK-- 125 ++L+DL++ R +A HP H + D M + ++ Sbjct: 91 VILWDLQDGKRYREVRFRAPVYGAELHPWNHHQFAAAL---FEDQPMLVDITEPVEVRYV 147 Query: 126 VWDTNTLQTADVFNF-------EETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSC 178 + + + E+ + + + GT ++ + D ++ Sbjct: 148 LPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNIIDARTREI 207 Query: 179 SHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVE 238 + + I + + +L A D ++ + V S LD + + Sbjct: 208 IYSEKIASGIITTLRLTESGRELLVNA-QDRIIRTFIVPNLSA--ADLDPDTIQLPLEHK 264 Query: 239 SANTAHNGKVNGLCFTSDGLHL-LTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKF 297 + + N + F++ G ++ + ++ + +W G +LV + + +++ Sbjct: 265 FQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIW--ERGHGSLVRMLEGPKEEQGVIEW 322 Query: 298 TVSCGCSSEFVFVPYGSTIAVYTVY 322 I +++V Sbjct: 323 HPHRAL--LAACGLETGRINIWSVT 345 >5OV3-A nrPDB Length = 381 Score = 73.4 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 54/379 (14%), Positives = 110/379 (29%), Gaps = 89/379 (23%) Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMF 115 G + G +DG IV++D H + V ++ W D Sbjct: 37 GTLLAVGCNDGRIVIWDFLTRG-------------IAKIISAHIHPVCSLCWS-RDGHKL 82 Query: 116 TSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVA--------------- 160 S+S D + WD + F F + P LV Sbjct: 83 VSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSK 142 Query: 161 --------------------------VGTRGPKVQLCDLKSGSCSHILQ-----GHRQEI 189 G K+ + S + + I Sbjct: 143 HVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAI 202 Query: 190 LAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVN 249 ++ ++ + L +AD ++++D R C +G+ + + + Sbjct: 203 KSIEFARKGSCFLIN-TADRIIRVYDGREILTC-----GRDGEPEPMQKLQDLVNRTPWK 256 Query: 250 GLCFTSDGLHLLTVGTD-NRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFV 308 CF+ DG +++ + + +W S G + +G ++ L V+ + Sbjct: 257 KCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHG-----TRGELLLDVAWHPVRPII 311 Query: 309 FVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEP 368 ++++ + + F +F+EL D N+ Sbjct: 312 ASISSGVVSIW------------AQNQVENWSAFAPDFKEL-----DENVEYEERESEFD 354 Query: 369 VPDDDETTTKSQLNPAFED 387 + D+D++ K A ED Sbjct: 355 IEDEDKSEPKQTGADAAED 373 Score = 61.9 bits (148), Expect = 5e-10, Method: Composition-based stats. Identities = 30/165 (18%), Positives = 60/165 (36%), Gaps = 22/165 (13%) Query: 197 RYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD 256 R+ +LA D R+ +WD ++ + +AH V LC++ D Sbjct: 35 RWGTLLAVGCNDGRIVIWDF----------------LTRGIAKIISAHIHPVCSLCWSRD 78 Query: 257 GLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTI 316 G L++ TDN + W+ +G+ + LK ++ + P S Sbjct: 79 GHKLVSASTDNIVSQWDVLSGDC-----DQRFRFPSPILKVQYHPRDQNKVLVCPMKSAP 133 Query: 317 AVYTVYSGEQITM-LKGHYKTVDCCVFQSNFQELYSGSRDCNILA 360 + T+ + + + + F + +Y+G+ IL Sbjct: 134 VMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILV 178 Score = 50.7 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 11/82 (13%), Positives = 27/82 (32%), Gaps = 3/82 (3%) Query: 283 NYGKVCNNSKKGLKFTVSCGCSSE---FVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDC 339 NY + + + + ++C + I ++ + ++ H V Sbjct: 13 NYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCS 72 Query: 340 CVFQSNFQELYSGSRDCNILAW 361 + + +L S S D + W Sbjct: 73 LCWSRDGHKLVSASTDNIVSQW 94 Score = 42.6 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 10/82 (12%), Positives = 23/82 (28%), Gaps = 5/82 (6%) Query: 250 GLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVF 309 F G L D R+ +W+ + + + + V Sbjct: 30 TCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIH-----PVCSLCWSRDGHKLVS 84 Query: 310 VPYGSTIAVYTVYSGEQITMLK 331 + ++ + V SG+ + Sbjct: 85 ASTDNIVSQWDVLSGDCDQRFR 106 >3JB9-S nrPDB Length = 488 Score = 72.6 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 34/212 (16%), Positives = 75/212 (35%), Gaps = 22/212 (10%) Query: 2 LGFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLS 61 + FL A +G L + + L+ H I +L + P +G ++ Sbjct: 298 VNFLQAHPSG---EYLLAASNEKCYIFSLKSQVYNITVAQH---ITSLAVHP-DGNLFVA 350 Query: 62 GGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFD 121 G +G + ++ + + + + H V+T+Q+ + + +++ D Sbjct: 351 GLENGELRFFETSSGNELTKF-------------GPHSSPVKTLQFGENGYWLVVTTNDD 397 Query: 122 KTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHI 181 + +WD + + V + + S LV+ V + S S + Sbjct: 398 SDIFIWDLRKSELVQKIPLQTKVAAVSLDITSQ--LLVSSDGETLYVHIYVKSSKSWRCM 455 Query: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKL 213 Q H I + W +L + S + ++L Sbjct: 456 SQTHVSSISNLVWLNELHQLLFSTSNGAILRL 487 Score = 57.2 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 25/190 (13%), Positives = 63/190 (33%), Gaps = 20/190 (10%) Query: 41 IHGGGINTLDIEPVEGRYMLSGGSDGVIVLY------DLENSSRQSYYTCKAVCSIGRDH 94 +H + LDI+ + G + + + + + S + S + Sbjct: 228 LHKDELLCLDIQSNSTLKIFEGSA--LACCWLTSSKIAVATADAISIFEFPVSSSGLQSV 285 Query: 95 PDVHR-----YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHM 149 + V +Q +P ++S +K ++ + T + H Sbjct: 286 GEPTSSIPIDEKVNFLQAHPSGE-YLLAASNEK-CYIFSLKSQVYNITVAQHITSLAVH- 342 Query: 150 SPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADS 209 L G +++ + SG+ H + + + +++ T + DS Sbjct: 343 ----PDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDS 398 Query: 210 RVKLWDVRRA 219 + +WD+R++ Sbjct: 399 DIFIWDLRKS 408 >5A9Q-0 nrPDB Length = 380 Score = 70.3 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 38/264 (14%), Positives = 87/264 (32%), Gaps = 24/264 (9%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H G + L + +++ S G + ++ +++ + + P YS Sbjct: 73 HHGDVMDLQF--FDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYS 130 Query: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 + + D + ++ + + + ++ H ++ + T L Sbjct: 131 SAPCTGVVCNNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEIL--T 188 Query: 162 GTRGPKVQLCDLKSG--SCSHILQGHRQEI--LAVSWSPRYDYILATASADSRVKLWDVR 217 ++++ D + S IL + V P +++AT D + +WDVR Sbjct: 189 VNSIGQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVR 248 Query: 218 RASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGL-HLLTVGTDNRMRLWNSSN 276 + + + L AH ++ + F HL T D + W++S Sbjct: 249 QGTMPVSLLK---------------AHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDAST 293 Query: 277 GENTLVNYGKVCNNSKKGLKFTVS 300 + S L ++S Sbjct: 294 DVPEKSSLFHQGGRSSTFLSHSIS 317 Score = 52.6 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 46/321 (14%), Positives = 90/321 (28%), Gaps = 61/321 (19%) Query: 59 MLSGGSDGV---IVLYDLEN-SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGM 114 +G D I L+ + + + S + + D H V +Q++ D Sbjct: 32 FATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDI--RHHGDVMDLQFF--DQER 87 Query: 115 FTSSSFDKTLKVW-DTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDL 173 ++S + V+ QT V T + H + G Sbjct: 88 IVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTG----------- 136 Query: 174 KSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKK 233 V +P + T D R+ L+ + T+D + Sbjct: 137 -----------------VVCNNPE----IVTVGEDGRINLFRADHK-EAVRTIDNADSST 174 Query: 234 SQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKK 293 AV T VN + ++++W+ N + + Sbjct: 175 LHAVTFLRTPEILTVNSI---------------GQLKIWDFRQQGNEPSQILSLTGDRVP 219 Query: 294 GLKFTVSCGCSSEFVFVPYGSTIAVYTVYSG-EQITMLKGHYKTVDCCVFQSNFQE-LYS 351 ++++ V G +++LK H + F + E L++ Sbjct: 220 LHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFT 279 Query: 352 GSRDCNILAWVPSLYEPVPDD 372 S D + W VP+ Sbjct: 280 CSEDGS--LWHWDASTDVPEK 298 Score = 39.5 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 5/62 (8%), Positives = 18/62 (29%), Gaps = 1/62 (1%) Query: 16 LRLRRAESTRRVLGLELNK-DRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLE 74 + + + + + + H + + P ++ + DG + +D Sbjct: 233 VATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDAS 292 Query: 75 NS 76 Sbjct: 293 TD 294 >5MC6-j nrPDB Length = 397 Score = 69.6 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 39/296 (13%), Positives = 91/296 (30%), Gaps = 31/296 (10%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H + ++ + E + + G ++ Y + + + + D ++S Sbjct: 67 HVDVLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMK---KHS 123 Query: 102 VETVQWYPHDTGMF----TSSSFDKTLKVWD---------------TNTLQTADVFNFEE 142 ++W + + ++ T +W + TL+ Sbjct: 124 FWALKWGASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPM 183 Query: 143 TVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQG------HRQEILAVSWSP 196 T S ++ L+A G VQ+ +L + + + + I +V +SP Sbjct: 184 TPSQFATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSP 243 Query: 197 RYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD 256 + +LA A + + S AH+ V L F Sbjct: 244 QGS-LLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDS 302 Query: 257 GLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPY 312 G L + G D ++R W+ + + + + + ++ + + P Sbjct: 303 GETLCSAGWDGKLRFWDVKT--KERITTLNMHCDDIEIEEDILAVDEHGDSLAEPG 356 Score = 57.2 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 43/319 (13%), Positives = 83/319 (26%), Gaps = 52/319 (16%) Query: 97 VHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADV-----------FNFEETVY 145 H + +V S S D LKVWD L + Sbjct: 14 AHDADIFSVS---ACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDV 70 Query: 146 SHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHI------------LQGHRQEILAVS 193 + + + CLVA + + + + ++ H A+ Sbjct: 71 LQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFW--ALK 128 Query: 194 WSPRYDYILA----TASADSRVKLWDVR--RASGCLITLDQHNGKKSQAVESANTAHNGK 247 W D +L+ +W +TL+ + Q + + Sbjct: 129 WGASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQF 188 Query: 248 VNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEF 307 + + G + T + +++ S + + +V Sbjct: 189 ATSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSL 247 Query: 308 VFVPYGST----IAVYTVYSGEQITMLK-------------GHYKTVDCCVFQSNFQELY 350 + + + S I +Y GE+I L H V F + + L Sbjct: 248 LAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLC 307 Query: 351 SGSRDCNILAWVPSLYEPV 369 S D + W E + Sbjct: 308 SAGWDGKLRFWDVKTKERI 326 Score = 48.4 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 42/338 (12%), Positives = 100/338 (29%), Gaps = 54/338 (15%) Query: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 + H I ++ + +S DG + ++D + ++ K+ H Sbjct: 13 KAHDADIFSVSAC---NSFTVSCSGDGYLKVWDNKLLDNENP-KDKSYSHFVHKSGLHHV 68 Query: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLV 159 ++ ++ + + ++SF L + FE+ + L Sbjct: 69 DVLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALK 128 Query: 160 AVGTRGPKV--QLCDLKSGSCSHILQGH----RQEILAVSWSPRYDY------------- 200 + + +L ++I + H L ++WSP + Sbjct: 129 WGASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQF 188 Query: 201 ----------ILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNG 250 ++AT + V++ ++ QH+ ++ + Sbjct: 189 ATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHS----------MINNSNSIRS 238 Query: 251 LCFTSDGLHLLTVGTDNR---MRLWNSSNGENTLVNYGKVC-------NNSKKGLKFTVS 300 + F+ G L N + L+ + GE + ++S Sbjct: 239 VKFSPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLS 298 Query: 301 CGCSSEFVF-VPYGSTIAVYTVYSGEQITMLKGHYKTV 337 S E + + + + V + E+IT L H + Sbjct: 299 FNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDI 336 >5WLC-LH nrPDB Length = 896 Score = 69.2 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 58/371 (15%), Positives = 110/371 (29%), Gaps = 44/371 (11%) Query: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 H + +L +G Y+LSGG + V+ L+ LE +S+Q + + Y Sbjct: 296 HIDSVLSLSFS-HDGSYLLSGGWEKVMSLWQLETNSQQFLPRLNGIIIDCQVLGPQGNYY 354 Query: 102 VETVQW----YPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHC 157 +Q D ++ D T K + VFN +S ++TK+ Sbjct: 355 SLILQMTENNSNSDYQFLLLNASDLTSK---LSINGPLPVFNSTIKHIQQPISAMNTKNS 411 Query: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 K K S I + V +P + S V+++D Sbjct: 412 NSITSLNHSK------KKQSRKLIKSRRQDFTTNVEINPINKNLYF--PHISAVQIFDFY 463 Query: 218 RASGCLIT-LDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLT-----------VGT 265 + L V + + L FT DG ++T Sbjct: 464 KNEQVNYQYLTSGVNNSMGKVRFELNLQDPIITDLKFTKDGQWMITYEIEYPPNDLLSSK 523 Query: 266 D--NRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEF------VFVPYGSTIA 317 D + ++ W ++ E KV N + T + + Sbjct: 524 DLTHILKFWTKNDNETNWNLKTKVINPHGISVPITKILPSPRSVNNSQGCLTADNNGGLK 583 Query: 318 VYTVYSGE---QITMLK----GHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVP 370 ++ S E + + H+ + + ++ G D + ++ Sbjct: 584 FWSFDSHESNWCLKKISLPNFNHFSNSVSLAWSQDGSLIFHGFDDK-LQILDFDTFKKFE 642 Query: 371 DDDETTTKSQL 381 + T T S+ Sbjct: 643 SLENTKTVSEF 653 Score = 51.5 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 47/285 (16%), Positives = 88/285 (30%), Gaps = 43/285 (15%) Query: 120 FDKTLKVWDTNTLQTADVFNFE--------------------ETVYSHHMSPVSTKHCLV 159 F+ +KV+ T Q F + + P L+ Sbjct: 48 FNNQIKVYSVETRQCVKTLKFANNSLLSGIFLQEEENNESIVKILLGDITVPQQEDAHLI 107 Query: 160 AVGTRGPKVQLCDLKSG---SCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 V T V + + K S H E LA + +Y + T D K + Sbjct: 108 TVFTNNGHVIVLNYKGKLVESPKHFKISLADEKLANVFHSEGNYRILTTFKDPSQKAHN- 166 Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTD---------- 266 S L L + KK V HN ++ + +S+G L + D Sbjct: 167 SLQSYRLYALTFDDAKKQFEVAHQAEWHNVILSNI--SSNGKLLAHMCKDVSTKDHEHKS 224 Query: 267 -NRMRLWNSSNG-----ENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYT 320 + + L++ S + L + + + + + + + I++ + Sbjct: 225 ISVVSLFDDSVNLSFPLGSILSSQTQSLSYNTRYVSSMAIDNMGQQLAVGFASGVISIVS 284 Query: 321 VYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSL 365 + + I +LK H +V F + L SG + + W Sbjct: 285 LADLQ-IRLLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLET 328 >5A9Q-2 nrPDB Length = 326 Score = 68.4 bits (165), Expect = 5e-12, Method: Composition-based stats. Identities = 29/199 (14%), Positives = 66/199 (33%), Gaps = 31/199 (15%) Query: 132 LQTADVFNFEETVYSHHMSPVSTKHCL-----VAVGTRGPKVQLC--DLKSGSCSHILQG 184 +T F+ V SP + L K++L DL+ + +L+G Sbjct: 63 YKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEG 122 Query: 185 HRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAH 244 H I + + P+ +A+ S D ++W++ L H Sbjct: 123 HTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVL-----------------H 165 Query: 245 NGKVNGLCFTSDGLH-LLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGC 303 + + +C+ + L+ + +R ++ + L + + L C Sbjct: 166 SPGM-SVCWHPEETFKLMVAEKNGTIRFYDLLAQQAILSL-----ESEQVPLMSAHWCLK 219 Query: 304 SSEFVFVPYGSTIAVYTVY 322 ++ V G+ ++ + Sbjct: 220 NTFKVGAVAGNDWLIWDIT 238 Score = 68.0 bits (164), Expect = 6e-12, Method: Composition-based stats. Identities = 42/269 (15%), Positives = 83/269 (30%), Gaps = 55/269 (20%) Query: 42 HGGGINTLDIEPVEGR-------YMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDH 94 HG ++ + P + +D I L +T Sbjct: 71 HGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRL-----------FTSDLQDKNEYKV 119 Query: 95 PDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVST 154 + H + + + P + S S D T ++W+ +QTA F S P T Sbjct: 120 LEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAH-FVLHSPGMSVCWHPEET 178 Query: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYIL-ATASADSRVKL 213 +VA + ++ DL + L+ + +++ W + + + A A D + Sbjct: 179 FKLMVA--EKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLI-- 234 Query: 214 WDV----------------------RRASGCLITLDQHNGKKSQAVESANTAHNGKV--- 248 WD+ S L + GK + + + H + Sbjct: 235 WDITRSSYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKMASQFQIHHLGHPQPILMG 294 Query: 249 -----NGLCFTSDGLHLLTVGTDNRMRLW 272 +GL + + G D+++ W Sbjct: 295 SVAVGSGLSWHRTLPLCVIGG-DHKLLFW 322 Score = 49.9 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 20/141 (14%), Positives = 43/141 (30%), Gaps = 20/141 (14%) Query: 245 NGKVNGLCFTS----DGLHLLTVGTDNRMRL----WNSSNGENTLVNYGKVCNNSKKGLK 296 V+ + F D +L+ G +N + + + + + Y + Sbjct: 16 EDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVRV 75 Query: 297 FTVSCGCSSE---------FVFVPYGSTIAVY--TVYSGEQITMLKGHYKTVDCCVFQS- 344 ++ + F I ++ + + +L+GH ++ VF Sbjct: 76 DGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPK 135 Query: 345 NFQELYSGSRDCNILAWVPSL 365 QE+ S S D W Sbjct: 136 EGQEIASVSDDHTCRIWNLEG 156 >3DW8-B nrPDB Length = 447 Score = 67.3 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 42/279 (15%), Positives = 85/279 (30%), Gaps = 41/279 (14%) Query: 30 LELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCS 89 +E + R H IN++ I Y+ D I L+ LE + R + Sbjct: 164 VEASPRRIFANAHTYHINSISINSDYETYL--SADDLRINLWHLEITDRSFNIVDIKPAN 221 Query: 90 IGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHM 149 + + + +++P+ F SS T+++ D Sbjct: 222 M-----EELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMR------------------- 257 Query: 150 SPVSTKHCLVAVGTRGPKVQLCD-LKSGSCSHILQGHRQEILAVSWSPRYDYILATASAD 208 A +L + + S I V +S Y++ + D Sbjct: 258 ----------ASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMM---TRD 304 Query: 209 S-RVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDN 267 VK+WD+ + + T H +S+ C+ ++T +N Sbjct: 305 YLSVKVWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNN 364 Query: 268 RMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSE 306 R+++ + + + + N + LK C Sbjct: 365 FFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKR 403 Score = 63.8 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 51/365 (13%), Positives = 117/365 (32%), Gaps = 77/365 (21%) Query: 35 DRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSR---------QSYYTCK 85 D DV I+T++ G + +G G +V++ E ++ Y T + Sbjct: 22 DDDVAEA--DIISTVEFN-HSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQ 78 Query: 86 AVCSIGRDHPDVH-RYSVETVQWYPH-DTGMFTSSSFDKTLKVWDTNTLQ---------- 133 + + + ++W P + F S+ DKT+K+W + Sbjct: 79 SHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKE 138 Query: 134 -----------------------------TADVFNFEETVYSHHMSPVSTKHCLVAVGTR 164 +F T + + +S S ++ Sbjct: 139 EDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSA--D 196 Query: 165 GPKVQLCDLKSGSCS--------HILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 ++ L L+ S ++ + I A + P +S+ ++L D+ Sbjct: 197 DLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDM 256 Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNR-MRLWNSS 275 R ++ C + + S + ++ + F+ G +++T D +++W+ + Sbjct: 257 RASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMT--RDYLSVKVWDLN 314 Query: 276 NGENTLVNY-------GKVCNNSKKGLKFT----VSCGCSSEFVFVPYGSTIAVYTVYSG 324 + Y K+C+ + F G S + Y + ++ + Sbjct: 315 MENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTK 374 Query: 325 EQITM 329 IT+ Sbjct: 375 RDITL 379 Score = 41.8 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 30/198 (15%), Positives = 66/198 (33%), Gaps = 25/198 (12%) Query: 4 FLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGG 63 +LSA + + L + + ++ ++ ++ + I + P + Sbjct: 192 YLSADDLRI-NLWHLEITDRSFNIVDIKPANMEELTEV----ITAAEFHPNSCNTFVYSS 246 Query: 64 SDGVIVLYDLENSS---RQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSF 120 S G I L D+ S+ R S + R S+ V++ +G + + Sbjct: 247 SKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFS--HSGRYMMTRD 304 Query: 121 DKTLKVWDTN-TLQTADVFNFEETVYSHHMSPVSTK-------------HCLVAVGTRGP 166 ++KVWD N + + + E + S S +V G+ Sbjct: 305 YLSVKVWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNN 364 Query: 167 KVQLCDLKSGSCSHILQG 184 ++ D ++ L+ Sbjct: 365 FFRMFD-RNTKRDITLEA 381 >5K19-A nrPDB Length = 569 Score = 61.9 bits (148), Expect = 5e-10, Method: Composition-based stats. Identities = 38/255 (14%), Positives = 77/255 (30%), Gaps = 42/255 (16%) Query: 146 SHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGH----RQEILAVSWSPRYDYI 201 +H++ + L+ VG +VQL D S + + + V W P + + Sbjct: 106 FNHLTATAESVSLL-VGFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESL 164 Query: 202 LATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLL 261 A + + L++V G + + + V+ Sbjct: 165 FLVAHSSGNMYLYNVEHTC----------GTTAPHYQLLKQGESFAVHTCK--------- 205 Query: 262 TVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTV 321 + T N + W G L V + V+ Sbjct: 206 SKSTRNPLLKWTVGEG----------------ALNEFAFSPDGKFLACVSQDGFLRVFNF 249 Query: 322 YSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQL 381 S E +K ++ + C + + + + +G D + W + KS + Sbjct: 250 DSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGH--KSWV 307 Query: 382 NPAFEDAWSSSDEEG 396 + D +++S EEG Sbjct: 308 SVVAFDPYTTSVEEG 322 Score = 59.9 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 36/294 (12%), Positives = 88/294 (29%), Gaps = 57/294 (19%) Query: 85 KAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNT-----------LQ 133 K + + + + V V+W P +F + + +++ L+ Sbjct: 135 KETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLK 194 Query: 134 TADVFNFEETVYSHHMSPV---------------STKHCLVAVGTRGPKVQLCDLKSGSC 178 + F +P+ S +A ++ +++ + S Sbjct: 195 QGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVEL 254 Query: 179 SHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVE 238 ++ + +L V WSP YI+ T D V +W V Sbjct: 255 HGTMKSYFGGLLCVCWSPDGKYIV-TGGEDDLVTVWS----------------FVDCRVI 297 Query: 239 SANTAHNGKVNGLCFTS------DGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSK 292 + H V+ + F +G + G+D + + + N + SK Sbjct: 298 ARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQ--DLLHFGRDRANSTQ-SRLSK 354 Query: 293 KGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSG-----EQITMLKGHYKTVDCCV 341 + + + F V + + ++ + + ++ + H ++ Sbjct: 355 RNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATS 408 Score = 46.5 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 45/297 (15%), Positives = 84/297 (28%), Gaps = 39/297 (13%) Query: 13 EDPLRLR--RAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVL 70 D L + RV + + + + GG+ + P +G+Y+++GG D ++ + Sbjct: 230 PDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSP-DGKYIVTGGEDDLVTV 288 Query: 71 YDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGM------FTSSSFDKTL 124 + V H+ V V + P+ T + S S + Sbjct: 289 WSF-------------VDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQ 335 Query: 125 KVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQG 184 + + + S PVS + +VG + ++ L DL IL Sbjct: 336 DLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVG-QDTQLCLWDLTE----DILFP 390 Query: 185 HRQEILAVSWSPR--YDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANT 242 H Q + S + V G + +N Sbjct: 391 H-QPLSRARTHTNVMNATSPPAGSNGNSV------TTPGNSVPPPLPRSNSLPHSAVSNA 443 Query: 243 AHNGKVNGLCFTSDGLHLLTVG-TDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFT 298 V S T+ D + R + + G + + S L Sbjct: 444 GSKSSVMDGAIASGVSKFATLSLHDRKER--HHEKDHKRNHSMGHISSKSSDKLNLV 498 >5AMS-A nrPDB Length = 431 Score = 61.5 bits (147), Expect = 6e-10, Method: Composition-based stats. Identities = 54/321 (16%), Positives = 98/321 (30%), Gaps = 39/321 (12%) Query: 96 DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVS-- 153 D H SV + +P + + + D +W + F T Y + S Sbjct: 62 DKHTDSVFAIGHHP-NLPLVCTGGGDNLAHLW--TSHSQPPKFAGTLTGYGESVISCSFT 118 Query: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSW---SPRYDYILATASADSR 210 ++ + KV + + G L QE+ + W P A + D Sbjct: 119 SEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGS 178 Query: 211 VKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMR 270 V + + G L L + + N L L+T D+ + Sbjct: 179 VWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTL-------ELVTCSLDSTIV 231 Query: 271 LWNSSNGENTLVNYGKVCNNSKKGLKF----------TVSCGCSSEFVFVPYGSTIAVYT 320 WN G+ K+ KGL+ T++ G S +AV Sbjct: 232 AWNCFTGQQLF----KITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVIN 287 Query: 321 VYSG------EQITMLKGHYK----TVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVP 370 +G + LK +++ + S F + G IL + S + Sbjct: 288 CNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTSAWRVRH 347 Query: 371 DDDETTTKSQLNPAFEDAWSS 391 + ++L +D ++S Sbjct: 348 KFVLEDSVTKLMFDNDDLFAS 368 Score = 61.5 bits (147), Expect = 6e-10, Method: Composition-based stats. Identities = 36/229 (15%), Positives = 70/229 (30%), Gaps = 31/229 (13%) Query: 172 DLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNG 231 D+ + S ++ H + A+ P ++ T D+ LW + Sbjct: 52 DMSNNSLTY-FDKHTDSVFAIGHHPNLP-LVCTGGGDNLAHLW--------------TSH 95 Query: 232 KKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNS 291 + T + V FTS+G L+T ++ + G + Sbjct: 96 SQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQ-MQEV 154 Query: 292 KKGLKFTVSCGCSSEFVFVPYGSTIAVY--TVYSGEQITMLKG--HYKTVDCCVFQSNFQ 347 ++ + + F F ++ Y G ++ G H + F + + Sbjct: 155 EEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDK 214 Query: 348 -----ELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSS 391 EL + S D I+AW + + + K E W S Sbjct: 215 GENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIK-----GLEAPWIS 258 Score = 43.4 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 22/174 (12%), Positives = 54/174 (31%), Gaps = 15/174 (8%) Query: 59 MLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSS 118 +++ D IV ++ + T + + + + +G+ Sbjct: 221 LVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGN---SGVVACG 277 Query: 119 SFDKTLKVWDTNTL------QTADVFNFEETVYSHHMSPV--STKHCLVAVGTRGPKVQL 170 S + L V + N T E+ + + S+K L+A+G ++ L Sbjct: 278 SNNGLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILL 337 Query: 171 CDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLI 224 D + H + + + L + + +V ++ R + Sbjct: 338 YDTSAWRVRHKFVL-EDSVTKLMFDNDD---LFASCINGKVYQFNARTGQEKFV 387 Score = 39.5 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 38/255 (14%), Positives = 74/255 (29%), Gaps = 32/255 (12%) Query: 45 GINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVET 104 I L P R G +DG + Y + + Q + + + T Sbjct: 156 EIVWLKTHPTIARTFAFGATDGSVWCYQI---NEQDGSLEQLMSGFVHQQDCSMGEFINT 212 Query: 105 VQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA------DVFNFEETVYSHHMSP---VSTK 155 + +T + S D T+ W+ T Q ++ E S ++P Sbjct: 213 DKG--ENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGN 270 Query: 156 HCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 +VA G+ + + + +G L + P D + D+ ++ Sbjct: 271 SGVVACGSNNGLLAVINCNNGGAILHLS------TVIELKPEQDEL------DASIESIS 318 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAH----NGKVNGLCFTSDGLHLLTVGTDNRMRL 271 + + H V L F +D L + ++ Sbjct: 319 WSSKFSLMAIGLVCGEILLYDTSAWRVRHKFVLEDSVTKLMFDNDD--LFASCINGKVYQ 376 Query: 272 WNSSNGENTLVNYGK 286 +N+ G+ V G Sbjct: 377 FNARTGQEKFVCVGH 391 >6CVZ-A nrPDB Length = 351 Score = 55.3 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 43/275 (15%), Positives = 90/275 (32%), Gaps = 29/275 (10%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHC 157 H + + + + G+ S+S D T+K+ T +N V+S + Sbjct: 73 HGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNAGRPVWSCCW--CLDEAN 130 Query: 158 LVAVGTRGPKVQLCDLKS-GSCSHILQGHRQ--EILAVSWSPRYDY-------ILATASA 207 + G + + D+++ S L + ++++S+ PR +LA Sbjct: 131 YIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAASAAFPYGGVLAGTLE 190 Query: 208 DSRVKLWDVRRASGCL-ITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD--GLHLLTVG 264 D+ W+ + L G ++ H + + D + +V Sbjct: 191 DAS--FWEQKMDFSHWPHVLPLEPGGCIDFQTENSSRH----CLVTYRPDKNHTTIRSVL 244 Query: 265 TDNRMRLWNSSNGENTLVNY-----GKVCNNSKKGLKFTVSCGCSSEFVFVP--YGSTIA 317 + RL ++ N + G C K F + V ++ Sbjct: 245 MEMSYRLDDTGNPICSCQPVHTFFGGPTCKLLTKNAIFQSPENDGNILVCTGDEAANSAL 304 Query: 318 VYTVYSGEQITMLKGHYKTVDCCVFQSN-FQELYS 351 ++ SG + L+ +D C F+ N L + Sbjct: 305 LWDAASGSLLQDLQTDQPVLDICPFEVNRNSYLAT 339 Score = 43.0 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 21/127 (16%), Positives = 34/127 (26%), Gaps = 14/127 (11%) Query: 5 LSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGS 64 LS P ++L K +HG I L +LS Sbjct: 36 LSCLVISQPSPQASFLPGFGVKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASL 95 Query: 65 DGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTL 124 D I L LE ++ Y V + W + + + ++ Sbjct: 96 DNTIKLTSLETNTVVQTYNA--------------GRPVWSCCWCLDEANYIYAGLANGSI 141 Query: 125 KVWDTNT 131 V+D Sbjct: 142 LVYDVRN 148 Score = 40.7 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 21/170 (12%), Positives = 52/170 (30%), Gaps = 33/170 (19%) Query: 108 YPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPK 167 + + + S ++ + P G Sbjct: 11 HKYHFQKTFTVSQAGNCRI--MAYCDALSCLVISQPSPQASFLP-------------GFG 55 Query: 168 VQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLD 227 V++ + S + H ++I +++S +L +AS D+ +KL + + Sbjct: 56 VKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNT------- 108 Query: 228 QHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVG-TDNRMRLWNSSN 276 V++ N V C+ D + + G + + +++ N Sbjct: 109 --------VVQTYNAG--RPVWSCCWCLDEANYIYAGLANGSILVYDVRN 148 Score = 36.1 bits (81), Expect = 0.030, Method: Composition-based stats. Identities = 43/258 (16%), Positives = 72/258 (27%), Gaps = 64/258 (24%) Query: 20 RAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSR- 78 ++T ++ LE N G + + E Y+ +G ++G I++YD+ N+S Sbjct: 94 SLDNTIKLTSLETNTVVQTYNA-GRPVWSCCWCLDEANYIYAGLANGSILVYDVRNTSSH 152 Query: 79 -QSYYTCKAVCSIG---------------------------------RDHPDVHRYSVET 104 Q KA C + H +E Sbjct: 153 VQELVAQKARCPLVSLSYMPRAASAAFPYGGVLAGTLEDASFWEQKMDFSHWPHVLPLEP 212 Query: 105 ----------------VQWYPHDTGMFT-SSSFDKTLKVWDTNT----LQTADVFNFEET 143 V + P S + + ++ DT Q F T Sbjct: 213 GGCIDFQTENSSRHCLVTYRPDKNHTTIRSVLMEMSYRLDDTGNPICSCQPVHTFFGGPT 272 Query: 144 V-----YSHHMSPVSTKHCLVAVGTR-GPKVQLCDLKSGSCSHILQGHRQEILAVSWSPR 197 + SP + + LV G L D SGS LQ Q +L + Sbjct: 273 CKLLTKNAIFQSPENDGNILVCTGDEAANSALLWDAASGSLLQDLQT-DQPVLDICPFEV 331 Query: 198 YDYILATASADSRVKLWD 215 + V ++ Sbjct: 332 NRNSYLATLTEKMVHIYK 349 Score = 33.0 bits (73), Expect = 0.25, Method: Composition-based stats. Identities = 12/78 (15%), Positives = 26/78 (33%), Gaps = 2/78 (2%) Query: 283 NYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVF 342 Y + +GL F+ + +TI + ++ + + CC Sbjct: 68 QYIPMHGKQIRGLAFS--SYLRGLLLSASLDNTIKLTSLETNTVVQTYNAGRPVWSCCWC 125 Query: 343 QSNFQELYSGSRDCNILA 360 +Y+G + +IL Sbjct: 126 LDEANYIYAGLANGSILV 143 >3DWL-C nrPDB Length = 377 Score = 53.8 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 45/260 (17%), Positives = 78/260 (30%), Gaps = 15/260 (5%) Query: 74 ENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVW----DT 129 +++ Y H V V W P + + S D+ V+ D Sbjct: 30 TATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPK-SNRIVTCSQDRNAYVYEKRPDG 88 Query: 130 NTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCS----HILQGH 185 QT + SP K AVG+ + +C + + H+ + Sbjct: 89 TWKQTLVLLRLNRAATFVRWSPNEDK---FAVGSGARVISVCYFEQENDWWVSKHLKRPL 145 Query: 186 RQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVES-ANTAH 244 R IL++ W P +LA AD + + G + A Sbjct: 146 RSTILSLDWHPNN-VLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEYPS 204 Query: 245 NGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCS 304 G V+ + F+ G L G D+ + + + S+ L+ + S Sbjct: 205 GGWVHAVGFSPSGNALAYAGHDSSVTI-AYPSAPEQPPRALITVKLSQLPLRSLLWANES 263 Query: 305 SEFVFVPYGSTIAVYTVYSG 324 + S I + SG Sbjct: 264 AIVAAGYNYSPILLQGNESG 283 Score = 51.8 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 36/269 (13%), Positives = 72/269 (26%), Gaps = 33/269 (12%) Query: 129 TNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQE 188 T Q + + Y H + + T ++ D + H + Sbjct: 1 MATSQVLHILP--KPSYEHAFNS-QRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKI 57 Query: 189 ILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKV 248 + V W+P+ + I+ T S D +++ R TL ++ Sbjct: 58 VTCVDWAPKSNRIV-TCSQDRNAYVYEKRPDGTWKQTLVLLRLNRAATF----------- 105 Query: 249 NGLCFTSDGLHLLTVGTDNRMRL---------WNSSNGENTLVNYGKVCNNSKKGLKFTV 299 + ++ + + + W S + + L + + + Sbjct: 106 --VRWSPNEDKFAVGSGARVISVCYFEQENDWWVSKHLKRPLRSTILSLDWHPNNVLLAA 163 Query: 300 SCGCSSEFVFVPY------GSTIAVYTVYSG-EQITMLKGHYKTVDCCVFQSNFQELYSG 352 C +V Y +V+ + V F + L Sbjct: 164 GCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEYPSGGWVHAVGFSPSGNALAYA 223 Query: 353 SRDCNILAWVPSLYEPVPDDDETTTKSQL 381 D ++ PS E P T SQL Sbjct: 224 GHDSSVTIAYPSAPEQPPRALITVKLSQL 252 >5WLC-LS nrPDB Length = 594 Score = 53.8 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 41/378 (10%), Positives = 96/378 (25%), Gaps = 57/378 (15%) Query: 30 LELNKDRDVERIHGG--GINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAV 87 L++ + +D H I +L P + +L+GG D + +Y ++ + + V Sbjct: 233 LDIVRLKDANASHPSHSAIQSLSFHPSKP-LLLTGGYDKTLRIYHIDGKTNHLVTSLHLV 291 Query: 88 CSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN----TLQTADVFNFEET 143 S + + ++ + + WD + T Sbjct: 292 GSPIQTCTFYTS-------LSNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSR 344 Query: 144 VYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILA 203 +Y H + S ++ VA S +LQG+ I + L Sbjct: 345 LYGHESTQRSFENFKVAHLQNSQT------NSVHGIVLLQGNNGWINIL--HSTSGLWLM 396 Query: 204 TASADSRV--------------------------KLWDVR-RASGCLITLDQHNGKKSQA 236 + + ++W+ +G +I + G Sbjct: 397 GCKIEGVITDFCIDYQPISRGKFRTILIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGIT 456 Query: 237 VESANTAHNGKVNGLCFTS--DGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKG 294 L + L + L++ +N + + Sbjct: 457 KIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTT 516 Query: 295 LKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGH------YKTVDCCVFQSNFQE 348 + + + + + + ++ V F + Sbjct: 517 TISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGL 576 Query: 349 LYSGSRDCNILAWVPSLY 366 L G+ + W + Y Sbjct: 577 LAVGNEQGKVRLWKLNHY 594 Score = 39.9 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 20/133 (15%), Positives = 47/133 (35%), Gaps = 13/133 (9%) Query: 219 ASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 ++ L+ + + + + +++ +H+ + L F LLT G D +R+++ Sbjct: 223 SNSKLLPPKKLDIVRLKDANASHPSHSA-IQSLSFHPSKPLLLTGGYDKTLRIYHIDGKT 281 Query: 279 NTLVNYGKVCNNSKKGLKF--TVSCGCSSEFVFVPYGSTIAVYTV----------YSGEQ 326 N LV + + + F ++S + + + E+ Sbjct: 282 NHLVTSLHLVGSPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEK 341 Query: 327 ITMLKGHYKTVDC 339 + L GH T Sbjct: 342 FSRLYGHESTQRS 354 >2VDU-B nrPDB Length = 450 Score = 53.4 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 40/238 (16%), Positives = 77/238 (32%), Gaps = 32/238 (13%) Query: 74 ENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNT-- 131 N T V S G P ++ Y + ++ ++ + + DK+L V+D + Sbjct: 78 SNKGDSIKRTAAKVPSPGLGAPPIYSY-IRNLRLTSDESRLIACADSDKSLLVFDVDKTS 136 Query: 132 ---LQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQ----G 184 L+ F F + + ++ T V + + V D+ S Q G Sbjct: 137 KNVLKLRKRFCFSKRPNAISIAEDDTT---VIIADKFGDVYSIDINSIPEEKFTQEPILG 193 Query: 185 HRQEILAVSW--SPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANT 242 H + V + T+ D +K+ + + V+ Sbjct: 194 HVSMLTDVHLIKDSDGHQFIITSDRDEHIKI---------------SHYPQCFIVDKWLF 238 Query: 243 AHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVN-YGKVCNNSKKGLKFTV 299 H V+ +C D LL+ G D+++ W+ G+N Y + Sbjct: 239 GHKHFVSSICCGKD-YLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAP 295 Score = 38.7 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 25/200 (12%), Positives = 57/200 (28%), Gaps = 17/200 (8%) Query: 187 QEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNG 246 I + + ++A A +D + ++DV + S ++ L + + Sbjct: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRP---------- 152 Query: 247 KVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSK--KGLKFTVSCGCS 304 N + D ++ + + ++ + + + Sbjct: 153 --NAISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGH 210 Query: 305 SEFVFVPYGSTIAVYTVYSGEQITM-LKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVP 363 + I + + L GH V ++ L +G D I AW Sbjct: 211 QFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDK-IFAWDW 269 Query: 364 SLYEPVPDDDETTT-KSQLN 382 + + D + K LN Sbjct: 270 KTGKNLSTFDYNSLIKPYLN 289 Score = 31.8 bits (70), Expect = 0.47, Method: Composition-based stats. Identities = 18/140 (12%), Positives = 47/140 (33%), Gaps = 22/140 (15%) Query: 13 EDPLRLRRAESTRRVLGLELNK------DRDVERIHGGGINTLDI--EPVEGRYMLSGGS 64 ED + A+ V +++N ++ H + + + + +++++ Sbjct: 159 EDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDR 218 Query: 65 DGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTL 124 D I + + C I H++ V ++ + S+ D + Sbjct: 219 DEHIKI------------SHYPQCFIVDKWLFGHKHFVSSICC--GKDYLLLSAGGDDKI 264 Query: 125 KVWDTNTLQTADVFNFEETV 144 WD T + F++ + Sbjct: 265 FAWDWKTGKNLSTFDYNSLI 284 >5WLC-LV nrPDB Length = 707 Score = 50.3 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 33/263 (12%), Positives = 79/263 (30%), Gaps = 43/263 (16%) Query: 23 STRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYY 82 L L DR H N +D +LS + L + + Q+ Sbjct: 82 HVYDFANLSLKFDR-----HTDAEN-VDFT------ILSDDWTKSVHLQNDRSIQFQNKG 129 Query: 83 TCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEE 142 I + + V ++ +S ++ ++ + + + F + Sbjct: 130 GLHYTTRIPKFGRSLVYNKVNC--------DLYVGASGNELYRL-NLEKGRFLNPFKLDT 180 Query: 143 TVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQ------EILAVSWSP 196 + ++ + L+A GT V+ D +S S L ++ S+ Sbjct: 181 --EGVNHVSINEVNGLLAAGTETNVVEFWDPRSRSRVSKLYLENNIDNRPFQVTTTSFRN 238 Query: 197 RYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD 256 A +++ ++D+R + +I + + + N K+ Sbjct: 239 DG-LTFACGTSNGYSYIYDLRTSEPSIIKDQGYGFDIKKIIWLDNVGTENKIVTC----- 292 Query: 257 GLHLLTVGTDNRMRLWNSSNGEN 279 ++W+ +G+ Sbjct: 293 --------DKRIAKIWDRLDGKA 307 >5WLC-LW nrPDB Length = 554 Score = 49.9 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 40/309 (12%), Positives = 96/309 (31%), Gaps = 51/309 (16%) Query: 18 LRRAESTRRVLGLELNKDRDVERIHGGGINTLD-IEPV------EGRYMLSGGSDGVIVL 70 E T +V E+ DV + +L P G ++L G G + Sbjct: 77 ENELEKTFKVQQSEIKSSVDVSTANKALDLSLKEFGPYHIKYAKNGTHLLITGRKGHVAS 136 Query: 71 YDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN 130 D ++ C + + + K ++D Sbjct: 137 MDWRKGQLRAELFLNETCHSATY----------------LQNEQYFAVAQKKYTFIYD-- 178 Query: 131 TLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEIL 190 + ++ ++ + + H+ + H L+ ++ D+ +G L+ + Sbjct: 179 -HEGTELHRLKQHIEARHLDFL-PYHYLLVTAGETGWLKYHDVSTGQLVSELRTKAGPTM 236 Query: 191 AVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNG 250 A++ +P ++ ++ ++ V LW + L G VN Sbjct: 237 AMAQNP-WNAVMHLGHSNGTVSLWSPSMPEPLVKLLSA----------------RGPVNS 279 Query: 251 LCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFV 310 + G ++ T G D M++W+ N+ ++ + T + + + Sbjct: 280 IAIDRSGYYMATTGADRSMKIWDIR-------NFKQLHSVESLPTPGTNVSISDTGLLAL 332 Query: 311 PYGSTIAVY 319 G + ++ Sbjct: 333 SRGPHVTLW 341 Score = 45.7 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 15/130 (11%), Positives = 38/130 (29%), Gaps = 5/130 (3%) Query: 251 LCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFV 310 L F L+T G ++ + S G+ K ++ Sbjct: 196 LDFLPYHYLLVTAGETGWLKYHDVSTGQLVSELRTK-----AGPTMAMAQNPWNAVMHLG 250 Query: 311 PYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVP 370 T+++++ E + L V+ + + + D ++ W ++ + Sbjct: 251 HSNGTVSLWSPSMPEPLVKLLSARGPVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQLH 310 Query: 371 DDDETTTKSQ 380 + T Sbjct: 311 SVESLPTPGT 320 >5LTD-A nrPDB Length = 525 Score = 49.5 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 31/204 (15%), Positives = 61/204 (29%), Gaps = 37/204 (18%) Query: 123 TLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGT------------------- 163 T+ ++D N ++ S+++ +A + Sbjct: 138 TIYIYDINNMRLLHTIETPSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQ 197 Query: 164 --RGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASG 221 R V + D K+ + +++ HR + A++ S +LATAS + Sbjct: 198 TVRNGDVIIFDAKTLQPTSVIEAHRTSLAAIALSKDG-LLLATASDKGTI---------- 246 Query: 222 CLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTL 281 + G K K+ L F+ D ++ + + GE Sbjct: 247 -IRVFSVATGIKLYQFRRGTYP--TKIYSLAFSPDNRFVIASSATETVHI--FRLGEEEA 301 Query: 282 VNYGKVCNNSKKGLKFTVSCGCSS 305 N K N + K V + Sbjct: 302 ANTIKSANKKARLTKAQVPNPLET 325 Score = 38.4 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 26/214 (12%), Positives = 66/214 (30%), Gaps = 16/214 (7%) Query: 178 CSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAV 237 C G ILAV + +L + + ++D+ L T++ + Sbjct: 113 CELTFPG---AILAVKLNRERLVVLL----EETIYIYDINNMR-LLHTIETPSNPNGLIA 164 Query: 238 ESANTAHN--GKVNGLCFTSDGLHLLTV-GTDNRMRLWNSSNGENTLVNYGKVCNNSKKG 294 S ++ +N + + +T+ +R + + + V + Sbjct: 165 LSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQTVRNGDVIIFDAKTLQPTSVIEAHRTS 224 Query: 295 LKFTVSCGCSSEFVFVPYGST--IAVYTVYSGEQITMLKGHYKT--VDCCVFQSNFQELY 350 L ++ + I V++V +G ++ + + F + + + Sbjct: 225 L-AAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAFSPDNRFVI 283 Query: 351 SGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPA 384 + S + + E K++L A Sbjct: 284 ASSATETVHIFRLGEEEAANTIKSANKKARLTKA 317 Score = 36.4 bits (82), Expect = 0.021, Method: Composition-based stats. Identities = 16/93 (17%), Positives = 34/93 (36%), Gaps = 8/93 (8%) Query: 96 DVHRYSVETVQWYPHDTGMFTSSSFDKTL-KVWDTNTLQTADVF---NFEETVYSHHMSP 151 + HR S+ + D + ++S T+ +V+ T F + +YS SP Sbjct: 219 EAHRTSLAAIALS-KDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAFSP 277 Query: 152 VSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQG 184 + V + V + L ++ ++ Sbjct: 278 DNR---FVIASSATETVHIFRLGEEEAANTIKS 307 >2I3T-A nrPDB Length = 341 Score = 49.5 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 47/330 (14%), Positives = 103/330 (31%), Gaps = 52/330 (15%) Query: 36 RDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLE--------------------- 74 +E+ I+ + I P + +++ DG + +Y + Sbjct: 4 VQIEQAPKDYISDIKIIPSKSLLLIT-SWDGSLTVYKFDIQAKNVDLLQSLRYKHPLLCC 62 Query: 75 ------------NSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDK 122 + + + S + ++ + + ++S+D Sbjct: 63 NFIDNTDLQIYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRICKYGDDKLIAASWDG 122 Query: 123 TLKVWDTNTLQT----ADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQ-----LCDL 173 ++V D N T + + + T + VG +VQ LC+ Sbjct: 123 LIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCED 182 Query: 174 KSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKK 233 +G+ G + +I V+ P+ A +S D RV + + G + + Sbjct: 183 DNGTIEE--SGLKYQIRDVALLPKEQEGYACSSIDGRVAV-EFFDDQGDDYNSSKRFAFR 239 Query: 234 SQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKK 293 + +T VN + F+ L T G+D + WN + N+ K +S Sbjct: 240 CHRLNLKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIK-NFAKFNEDSVV 298 Query: 294 GLKFT-----VSCGCSSEFVFVPYGSTIAV 318 + + ++ + TI + Sbjct: 299 KIACSDNILCLATSDDTFKTNAAIDQTIEL 328 Score = 46.8 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 36/300 (12%), Positives = 81/300 (27%), Gaps = 17/300 (5%) Query: 99 RYSVETVQWYPHDTGMFTSSSFDK--TLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKH 156 + + ++ P + + + S+D T+ +D + + + + Sbjct: 11 KDYISDIKIIPSKSLLLIT-SWDGSLTVYKFDIQAKNVDLLQSLRYKHPLLCCNFIDNTD 69 Query: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 + VGT ++ DL L + + D L AS D +++ D Sbjct: 70 LQIYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRICKYGDDKLIAASWDGLIEVIDP 129 Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGL----HLLTVGTDN-RM-- 269 R +I + N ++ T + ++ L DN + Sbjct: 130 RNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDNGTIEE 189 Query: 270 --RLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQI 327 + + +S G + + + + Sbjct: 190 SGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTN 249 Query: 328 TMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFED 387 V+ F + LY+ D I W + + + + S + A D Sbjct: 250 LAY-----PVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACSD 304 >5TF2-A nrPDB Length = 407 Score = 48.4 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 36/230 (15%), Positives = 69/230 (30%), Gaps = 29/230 (12%) Query: 129 TNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQE 188 LQ + + + + L+A G V++ + S + H E Sbjct: 159 VENLQAVQTDFSSDPLQKVVC--FNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGE 216 Query: 189 ILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKV 248 I ++ P L T D + +W + L + ++T + + Sbjct: 217 IEDLALGPDGK--LVTVGRDLKASVWQKDQ-------LVTQLHWQENGPTFSSTPYRYQA 267 Query: 249 NGLCFTSD---GLHLLTVGTDNR---------MRLWNSSNGENTLVNYGKVCNNSKKGLK 296 D GL L TV ++ + W+ G N L K C + Sbjct: 268 CRFGQVPDQPAGLRLFTVQIPHKRLRQPPPCYLTAWD---GSNFLPLRTKSCGHEVVSCL 324 Query: 297 FTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITML-KGHYKTVDCCVFQSN 345 G + ++A+Y +S + + + + H V F Sbjct: 325 DVSESG--TFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPE 372 Score = 43.4 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 12/74 (16%), Positives = 24/74 (32%), Gaps = 1/74 (1%) Query: 289 NNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQE 348 +S K ++ + V+ V S E++ K H ++ + + Sbjct: 169 FSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK- 227 Query: 349 LYSGSRDCNILAWV 362 L + RD W Sbjct: 228 LVTVGRDLKASVWQ 241 Score = 41.1 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 35/223 (15%), Positives = 69/223 (30%), Gaps = 34/223 (15%) Query: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN 75 L + RV + + + H G I L + P +++ G D ++ + Sbjct: 187 LATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDG--KLVTVGRDLKASVWQKDQ 244 Query: 76 SSRQSYYTCKAVCSIGRDHPDVHRYSVETVQW-----YPHDTGMFTSSSFDKTLK----- 125 Q ++ Y + ++ P +FT K L+ Sbjct: 245 LVTQLHWQENGPTF------SSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQPPPC 298 Query: 126 ---VWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCS-HI 181 WD + + V VS + +GT V + S C ++ Sbjct: 299 YLTAWDGSNFLPLRTKSCGHEV--VSCLDVSESGTFLGLGTVTGSVAIYIAFSLQCLYYV 356 Query: 182 LQGHRQEILAVSWSPR----------YDYILATASADSRVKLW 214 + H + V++ P ++ L + + DSR +L Sbjct: 357 REAHGIVVTDVAFLPEKGRGPELLGSHETALFSVAVDSRCQLH 399 Score = 37.2 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 32/240 (13%), Positives = 66/240 (27%), Gaps = 45/240 (18%) Query: 54 VEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG 113 + + +GG+DG + ++ + + + + H +E + P Sbjct: 182 HDNTLLATGGTDGYVRVWKVPSLEKVLEFK-------------AHEGEIEDLALGPDGK- 227 Query: 114 MFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVA------VGTRGPK 167 + D VW Q +++E + +P + C G R Sbjct: 228 -LVTVGRDLKASVW--QKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFT 284 Query: 168 VQL---------------CDLKSGSCSHILQ-GHRQEILAVSWSPRYDYILATASADSRV 211 VQ+ D + GH + + S L + V Sbjct: 285 VQIPHKRLRQPPPCYLTAWDGSNFLPLRTKSCGHE-VVSCLDVS-ESGTFLGLGTVTGSV 342 Query: 212 KLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL 271 ++ + H + ++ G S L +V D+R +L Sbjct: 343 AIYIAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPELLG----SHETALFSVAVDSRCQL 398 Score = 33.0 bits (73), Expect = 0.26, Method: Composition-based stats. Identities = 19/152 (12%), Positives = 43/152 (28%), Gaps = 4/152 (2%) Query: 218 RASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNG 277 + + L+ NG+ S ++ ++ L D +L G D +L Sbjct: 60 KNGVHFLQLELINGRLSASLLHSHDTETRATMNLALAGD---ILAAGQDAHCQLLRFQAH 116 Query: 278 ENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTV 337 + K + + + + + + + V + + + Sbjct: 117 QQQGNKAEKAGSKEQGPRQRKGAAPAEKKCGAETQHEGLEL-RVENLQAVQTDFSSDPLQ 175 Query: 338 DCCVFQSNFQELYSGSRDCNILAWVPSLYEPV 369 F + L +G D + W E V Sbjct: 176 KVVCFNHDNTLLATGGTDGYVRVWKVPSLEKV 207 >6IYY-A nrPDB Length = 317 Score = 48.0 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 43/308 (13%), Positives = 88/308 (28%), Gaps = 40/308 (12%) Query: 26 RVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCK 85 RV + K+++ + GG+ +++ L GG ++++D K Sbjct: 31 RVYNTDPLKEKEKQEFLEGGVGHVEMLFRCNYLALVGGGKKKVMIWD----------DLK 80 Query: 86 AVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTL-QTADVFNFEETV 144 I + V+ V+ D + D +KV+ VF Sbjct: 81 KKTVIEIEFSTE----VKAVKLR-RDRIVVV---LDSMIKVFTFTHNPHQLHVFETCYNP 132 Query: 145 YSHH-MSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHI-LQGHRQEILAVSWSPRYDYIL 202 + P S L GT VQL DL S + + H + ++ + + I Sbjct: 133 KGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEGVLSCIALNLQGTRIA 192 Query: 203 ATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLT 262 + + ++++D E + + + F D + Sbjct: 193 TASEKGTLIRIFDTSSGH--------------LIQELRRGSQAANIYCINFNQDASLICV 238 Query: 263 VGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSE--FVFVPYGSTIAVYT 320 + ++ + + ++ G + G GS Sbjct: 239 SSDHGTVHIFAAEDPKSKWSFSK---FQVPSGSPCICAFGTEPNAVIAICADGSYYKFLF 295 Query: 321 VYSGEQIT 328 GE I Sbjct: 296 NPKGECIR 303 Score = 44.1 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 27/219 (12%), Positives = 66/219 (30%), Gaps = 31/219 (14%) Query: 159 VAVGTRGPKVQLCD---LKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 ++ + LK L+G + V R +Y+ +V +WD Sbjct: 21 CFACGMENGFRVYNTDPLKEKEKQEFLEG---GVGHVEMLFRCNYLALVGGGKKKVMIWD 77 Query: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 K + V + +V + D + ++ D+ ++++ + Sbjct: 78 ---------------DLKKKTVIEIEF--STEVKAVKLRRDRIVVV---LDSMIKVFTFT 117 Query: 276 NGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGST-IAVYTVY-SGEQITMLKGH 333 + + L + N KGL +S F + + + + + + + H Sbjct: 118 HNPHQLHVFETCYN--PKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAH 175 Query: 334 YKTVDCCVFQSNFQELYSGSRDCN-ILAWVPSLYEPVPD 371 + C + + S I + S + + Sbjct: 176 EGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQE 214 >5AJA-A nrPDB Length = 361 Score = 44.5 bits (103), Expect = 7e-05, Method: Composition-based stats. Identities = 35/182 (19%), Positives = 68/182 (37%), Gaps = 30/182 (16%) Query: 43 GGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSV 102 G E ML G G + LY++ + ++ Y C H ++ Sbjct: 37 ESGFTCCAFSARERFLML-GTCTGQLKLYNVFSGQEEASYNC-------------HNSAI 82 Query: 103 ETVQWYPHDTGMFTSSSFDKTLK-VWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 ++ + + TS+++ + L +W VF+ + + H S + Sbjct: 83 THLEPSRDGSLLLTSATWSQPLSALWGM-----KSVFDMKHSFTEDHYVEFSKHSQDRVI 137 Query: 162 GTRGPKVQLCDLKSGSCSHILQ----GHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 GT+G + D+++G+ L + + +++P D +L D LWDVR Sbjct: 138 GTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVL----NDGV--LWDVR 191 Query: 218 RA 219 A Sbjct: 192 SA 193 Score = 34.9 bits (78), Expect = 0.055, Method: Composition-based stats. Identities = 28/189 (14%), Positives = 57/189 (30%), Gaps = 32/189 (16%) Query: 190 LAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVN 249 ++S R +++ ++KL++V E++ HN + Sbjct: 41 TCCAFSARERFLMLGTCT-GQLKLYNVFSGQE----------------EASYNCHNSAIT 83 Query: 250 GLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVF 309 L + DG LLT T W+ + +S + S + V Sbjct: 84 HLEPSRDGSLLLTSAT------WSQPLSALWGMKSVFDMKHSFTEDHYVEFSKHSQDRVI 137 Query: 310 VPYGSTIAVYTVYSGEQITML----KGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSL 365 G +Y + +G ++ L + +C F + D W Sbjct: 138 GTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVL---NDGV--LWDVRS 192 Query: 366 YEPVPDDDE 374 + + D+ Sbjct: 193 AQAIHKFDK 201 >6N8P-A nrPDB Length = 979 Score = 43.4 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 27/257 (10%), Positives = 73/257 (28%), Gaps = 29/257 (11%) Query: 131 TLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQG-HR--Q 187 F + + S ++A+GTR ++L G+ G H+ Sbjct: 13 NKTVEHGFPHQPSALG-----YSPSLRILAIGTRSGAIKLY----GAPGVEFMGLHQENN 63 Query: 188 EILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGK 247 + + P L T D+ + LW ++ G + Q + + + Sbjct: 64 AVTQIHLLP-GQCQLVTLLDDNSLHLWSLKVKGG--ASELQEDESFTLRGPPGAAPSATQ 120 Query: 248 VNGLCFTSDGLHLLTVGTDNRMRLW---------NSSNGENTLVNYGKVCNNSKKGLKFT 298 + + S L + + + + + ++ ++ + Sbjct: 121 ITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMV 180 Query: 299 VSCGCSSE----FVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSR 354 + + + ++ + + + ++ +Q + + L S Sbjct: 181 EALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLS-SQQLENIWWQRDGRLLVSCHS 239 Query: 355 DCNILAWVPSLYEPVPD 371 D + W S P+ Sbjct: 240 DGSYCQWPVSSEAQQPE 256 Score = 35.7 bits (80), Expect = 0.040, Method: Composition-based stats. Identities = 9/41 (21%), Positives = 16/41 (39%) Query: 47 NTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAV 87 +L P + +L+G DG + +D + Y V Sbjct: 415 TSLTPAPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTV 455 Score = 33.4 bits (74), Expect = 0.17, Method: Composition-based stats. Identities = 28/248 (11%), Positives = 62/248 (25%), Gaps = 53/248 (21%) Query: 59 MLSGGSDGVIVLYDLE-NSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTS 117 +++ D + L+ L+ ++ G + V + + Sbjct: 77 LVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCE-LLYL 135 Query: 118 SSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGS 177 + + V + +S + L + Sbjct: 136 GTESGNVFV---------VQLPAFRALEDRTISSDAVLQRL--------------PEEAR 172 Query: 178 CSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAV 237 + + + A+ PR + + V +WD++ + L + Sbjct: 173 HRRVFEM----VEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIW-- 226 Query: 238 ESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENT------LVNYGKV-CNN 290 + DG L++ +D W S+ LV YG C Sbjct: 227 ---------------WQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKA 271 Query: 291 SKKGLKFT 298 + L T Sbjct: 272 ITRILWLT 279 Score = 33.0 bits (73), Expect = 0.23, Method: Composition-based stats. Identities = 15/65 (23%), Positives = 25/65 (38%), Gaps = 6/65 (9%) Query: 124 LKVWD----TNTLQTADVFNFEETVYSH-HMSPVSTKHCLVAVGTRGPKVQLCDLKSGSC 178 LK+W+ + Q A E + ++P + L+ G V+ D SG C Sbjct: 387 LKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWD-ASGVC 445 Query: 179 SHILQ 183 +L Sbjct: 446 LRLLY 450 Score = 33.0 bits (73), Expect = 0.24, Method: Composition-based stats. Identities = 20/148 (13%), Positives = 37/148 (25%), Gaps = 26/148 (17%) Query: 109 PHDTGMFTSSSFDKTLKVWDTNTLQTADVFN--------FEETVYSHHMSPVSTKHC--L 158 P + + D T++ WD + + +T + + S L Sbjct: 421 PPQRDLLLTGHEDGTVRFWD-ASGVCLRLLYKLSTVRVFLTDTDPNENFSAQGEDEWPPL 479 Query: 159 VAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRR 218 VG+ P D + G I + Y LA A +V + ++ Sbjct: 480 RKVGSFDPYSD--DPRLG------------IQKIFLCKYSGY-LAVAGTAGQVLVLELND 524 Query: 219 ASGCLITLDQHNGKKSQAVESANTAHNG 246 + H Sbjct: 525 EAAEQAVEQVEADLLQDQEGYRWKGHER 552 >4AV8-A nrPDB Length = 339 Score = 41.8 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 51/334 (15%), Positives = 107/334 (32%), Gaps = 54/334 (16%) Query: 95 PDVH-RYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVS 153 P+ H + ++ + + S T K +D + +E + + + Sbjct: 9 PENHVSNPIVDYEFNQDQSCLIVS-----TPKSFDIYNVHPLKRIMSQEMPDAGTIRMLH 63 Query: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRV-- 211 + + V T+ + + D ++ + + S ++I+ + + Sbjct: 64 RTNYIAFVSTKKELLHIWDDVKKQDITRVKL-DAAVKDLFLS--REFIVVSQGDVISIFK 120 Query: 212 --KLW-----DVRRASGCL------------------ITLDQHNGKKSQAVESANTAHNG 246 W D++ C +T Q + ++ AH Sbjct: 121 FGNPWNKITEDIKFGGVCEFANGLLVYSNEFNLGQIHVTRLQTDAEQVVGKGVLVKAHAN 180 Query: 247 KVNGLCFTSDGLHLLTVGTDNR-MRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSS 305 V + G + T D +R++ + NG + S ++++ S Sbjct: 181 PVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWS---PDGS 237 Query: 306 EFVFVPYGSTIAVYTVYSGEQITMLKGH--YKTVDCCVFQS-----NFQELYS-GSRDCN 357 + V T+ V+ V++ K H ++ FQS NF+ S GS DC Sbjct: 238 KLAVVSDKWTLHVFEVFNDA---ENKRHVLKDWINIKYFQSEWSICNFKLKVSKGSNDCK 294 Query: 358 ILAWVPSLYEPVPDDDETTTKS-QLNPA-FEDAW 389 I AW+ + + + +LN E W Sbjct: 295 I-AWISDTGLVIVWPNRRLADTFKLNYNDDEHVW 327 >3WJ9-A nrPDB Length = 412 Score = 41.1 bits (94), Expect = 8e-04, Method: Composition-based stats. Identities = 16/131 (12%), Positives = 40/131 (30%), Gaps = 18/131 (13%) Query: 245 NGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCS 304 G ++ +C+ +D + + + V + S Sbjct: 268 EGPIHDVCWNADSKEF------GIVYGYMPAKTAIFDNRANVVSIIPPAPRNTLIFSPNS 321 Query: 305 SEFVFVPYGS---TIAVYTVYSG-EQITMLKGHYKTVDCCVFQSNFQELYSGSR------ 354 + +G+ +I ++ + ++IT ++ C F + Q L + Sbjct: 322 RYILLAGFGNLQGSIDIFDAANNMKKITTVEA--ANCTYCEFSPDSQFLLTAVTSPRLRV 379 Query: 355 DCNILAWVPSL 365 D +I W + Sbjct: 380 DNSIKIWHITG 390 Score = 34.9 bits (78), Expect = 0.060, Method: Composition-based stats. Identities = 17/94 (18%), Positives = 32/94 (34%), Gaps = 25/94 (26%) Query: 190 LAVSWSPRYDYILATASAD--SRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGK 247 + +SP YIL + + ++D + T++ N Sbjct: 313 NTLIFSPNSRYILLAGFGNLQGSIDIFDAANNMKKITTVEAAN----------------- 355 Query: 248 VNGLCFTSDGLHLLTVGT------DNRMRLWNSS 275 F+ D LLT T DN +++W+ + Sbjct: 356 CTYCEFSPDSQFLLTAVTSPRLRVDNSIKIWHIT 389 >4YHC-A nrPDB Length = 468 Score = 38.0 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 19/123 (15%), Positives = 38/123 (30%), Gaps = 8/123 (6%) Query: 214 WDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 W TL + + +E H + + + + +VG D + +W+ Sbjct: 3 WSDHDELSTDTTLHEEKFR----IEPVPVHHQLDILKIAVSENYKTFASVGLDRSLVVWD 58 Query: 274 SSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGH 333 LV + LK ++ +V + T+ + V S + H Sbjct: 59 LRQWCTKLVLSK---EQMPRTLKA-IALDPQGNYVSLFSKDTLFILNVESPSLMLQHSYH 114 Query: 334 YKT 336 K Sbjct: 115 SKP 117 Score = 32.2 bits (71), Expect = 0.40, Method: Composition-based stats. Identities = 17/118 (14%), Positives = 42/118 (35%), Gaps = 3/118 (2%) Query: 71 YDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN 130 + ++ + T P H+ + + + F S D++L VWD Sbjct: 3 WS-DHDELSTDTTLHEEKFRIEPVPVHHQLDILKIAVS-ENYKTFASVGLDRSLVVWDLR 60 Query: 131 TLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQE 188 T V + E+ + + + V++ ++ + + +++S S H + Sbjct: 61 QWCTKLVLSKEQMPRTLKAIALDPQGNYVSLFSKD-TLFILNVESPSLMLQHSYHSKP 117 >4FHN-A nrPDB Length = 394 Score = 37.6 bits (85), Expect = 0.011, Method: Composition-based stats. Identities = 17/105 (16%), Positives = 38/105 (36%), Gaps = 14/105 (13%) Query: 24 TRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYT 83 T+ VLG + V I + + D + + + S G D ++++ L + Sbjct: 126 TQHVLGGKSGHHNFVNDIDIADVYSAD-NRLAEQVIASVGDDCTLIIWRL--TDEGPILA 182 Query: 84 CKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWD 128 + S G +VQ+ P + + ++++D Sbjct: 183 GYPLSSPGI-----------SVQFRPSNPNQLIVGERNGNIRIFD 216 Score = 31.0 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 25/134 (18%), Positives = 48/134 (35%), Gaps = 23/134 (17%) Query: 195 SPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLC-- 252 SP Y LA D+ V+L + + +IT Q V + H+ VN + Sbjct: 98 SPVYSLFLACVCQDNTVRL--IITKNETIIT---------QHVLGGKSGHHNFVNDIDIA 146 Query: 253 --FTSD----GLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSE 306 +++D + +VG D + +W ++ L Y S G+ ++ Sbjct: 147 DVYSADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYPL----SSPGISVQFRPSNPNQ 202 Query: 307 FVFVPYGSTIAVYT 320 + I ++ Sbjct: 203 LIVGERNGNIRIFD 216 >5GRS-A nrPDB Length = 396 Score = 37.2 bits (84), Expect = 0.014, Method: Composition-based stats. Identities = 19/123 (15%), Positives = 38/123 (30%), Gaps = 8/123 (6%) Query: 214 WDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 W TL + + +E H + + + + +VG D + +W+ Sbjct: 3 WSDHDELSTDTTLHEEKFR----IEPVPVHHQLDILKIAVSENYKTFASVGLDRCLVVWD 58 Query: 274 SSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGH 333 LV + LK ++ +V + T+ + V S + H Sbjct: 59 LRQWCTKLVLSK---EQMPRTLKA-IALDPQGNYVSLFSKDTLFILNVESPSLMLQHSYH 114 Query: 334 YKT 336 K Sbjct: 115 CKP 117 Score = 30.3 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 15/105 (14%), Positives = 38/105 (36%), Gaps = 3/105 (2%) Query: 71 YDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN 130 + ++ + T P H+ + + + F S D+ L VWD Sbjct: 3 WS-DHDELSTDTTLHEEKFRIEPVPVHHQLDILKIAVS-ENYKTFASVGLDRCLVVWDLR 60 Query: 131 TLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKS 175 T V + E+ + + + V++ ++ + + +++S Sbjct: 61 QWCTKLVLSKEQMPRTLKAIALDPQGNYVSLFSKD-TLFILNVES 104 >5L8S-A nrPDB Length = 604 Score = 35.7 bits (80), Expect = 0.033, Method: Composition-based stats. Identities = 29/152 (19%), Positives = 53/152 (34%), Gaps = 11/152 (7%) Query: 148 HMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQE-ILAVSWSPRYDYILAT-- 204 + + S + LV K+ L + L HR E + + P Y+LA Sbjct: 20 NFAVSSDEKRLVFNANLNGKMNLWAMDLPDTYPYLFAHRDESCNFIKFDPENRYVLAGFD 79 Query: 205 ASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVG 264 D +++ + G L G S+ ++ + +GK + + L Sbjct: 80 KDGDENYQIYAIPNEGGLPHPLI--TGDASEKYYFSHLSADGKCVYYETSKENPSFLNT- 136 Query: 265 TDNRMRLWNSSNGENTLVNYGKVCNNSKKGLK 296 R+ N GE+ L+N G+V + Sbjct: 137 -----RIRNLETGEDRLLNVGEVSTTELAAVS 163 >5CWW-B nrPDB Length = 595 Score = 34.5 bits (77), Expect = 0.084, Method: Composition-based stats. Identities = 18/96 (18%), Positives = 34/96 (35%), Gaps = 6/96 (6%) Query: 187 QEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAV-ESANTAHN 245 +I + SP D++ S V + + +S I K + + + Sbjct: 115 DDIRQLVMSPNQDFLAVLTS--HTVHICILPDSSHLHIQDTTPFKPKFWTLGPTTHVTSR 172 Query: 246 GKVNGLCFTS---DGLHLLTVGTDNRMRLWNSSNGE 278 V + +G L+TV D +R+W S + Sbjct: 173 SAVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTAD 208 Score = 28.3 bits (61), Expect = 6.5, Method: Composition-based stats. Identities = 9/43 (20%), Positives = 14/43 (32%), Gaps = 3/43 (6%) Query: 336 TVDCCVFQS---NFQELYSGSRDCNILAWVPSLYEPVPDDDET 375 V V+ N L + + D + W S + D T Sbjct: 174 AVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTADRWTFDAPT 216 >5BPT-A nrPDB Length = 741 Score = 33.7 bits (75), Expect = 0.15, Method: Composition-based stats. Identities = 9/70 (12%), Positives = 23/70 (32%), Gaps = 3/70 (4%) Query: 289 NNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKT---VDCCVFQSN 345 + F V + ++ + + +++ L + T V C ++ + Sbjct: 10 KQLPHEIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTGKEVTCLAWRPD 69 Query: 346 FQELYSGSRD 355 + L G D Sbjct: 70 GKILAFGLAD 79 Score = 32.6 bits (72), Expect = 0.29, Method: Composition-based stats. Identities = 8/67 (11%), Positives = 23/67 (34%) Query: 95 PDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVST 154 + V + W P + + K + + D ++ F+ E + V+ Sbjct: 54 NENTGKEVTCLAWRPDGKILAFGLADTKKVILCDVEKPESLHSFSLETPISCMQWMEVNV 113 Query: 155 KHCLVAV 161 ++ ++ Sbjct: 114 ENSVLTS 120 >5BPW-A nrPDB Length = 843 Score = 33.0 bits (73), Expect = 0.24, Method: Composition-based stats. Identities = 8/70 (11%), Positives = 21/70 (30%), Gaps = 3/70 (4%) Query: 289 NNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKT---VDCCVFQSN 345 + + F V + ++ + S ++ + T V C ++ + Sbjct: 17 KQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPD 76 Query: 346 FQELYSGSRD 355 + L D Sbjct: 77 GKLLAFALAD 86 Score = 33.0 bits (73), Expect = 0.25, Method: Composition-based stats. Identities = 10/67 (14%), Positives = 24/67 (35%) Query: 95 PDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVST 154 + V + W P + + + K + + D ++ F+ E V H V+ Sbjct: 61 NENTGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSVEAPVSCMHWMEVTV 120 Query: 155 KHCLVAV 161 + ++ Sbjct: 121 ESSVLTS 127 Score = 31.4 bits (69), Expect = 0.62, Method: Composition-based stats. Identities = 21/95 (22%), Positives = 34/95 (35%), Gaps = 15/95 (15%) Query: 187 QEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNG 246 QEI+ + WSP+ D ++A A+ V L + N K Sbjct: 21 QEIIFLVWSPKRD-LIALANTAGEVLLHRLASFHRVWSFPPNENTGK------------- 66 Query: 247 KVNGLCFTSDGLHLLTVGTD-NRMRLWNSSNGENT 280 +V L + DG L D ++ L + E+ Sbjct: 67 EVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESL 101 >6IGR-A nrPDB Length = 656 Score = 33.0 bits (73), Expect = 0.26, Method: Composition-based stats. Identities = 28/177 (15%), Positives = 54/177 (30%), Gaps = 20/177 (11%) Query: 168 VQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADS-RVKLWDVRRASGCLITL 226 + L D+++ I A+SW P +L S D + W L T Sbjct: 179 LWLYDVEA-DKLREWYAPEIGIGALSWWPDSRGVLIVQSEDEWQASQWRQDVYDLPLPTA 237 Query: 227 DQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLT----VGTDNR--MRLWNSSNGENT 280 D + ++ + AH GL DG G N L+ NG++ Sbjct: 238 DAP-AAPQKLLDWNSAAH-----GLAPHPDGQRFALIGRPAGKGNTEHAHLYLIENGQHR 291 Query: 281 LVNYGKVC--NNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYK 335 ++ G ++ G + ++ +++ + + H Sbjct: 292 RLDTGHDHPVGDAVGGDCHVGAFPEGPRWL----DGDTLLFSSTVRGSVGLFTAHIG 344 >2XE4-A nrPDB Length = 751 Score = 32.6 bits (72), Expect = 0.28, Method: Composition-based stats. Identities = 27/186 (14%), Positives = 50/186 (26%), Gaps = 19/186 (10%) Query: 69 VLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFD---KTLK 125 ++ QS C + H + DT S + Sbjct: 248 KVWRHVMGKLQSEDVCLY---------EEHNPLFSAFMYKAADTNTLCIGSQSPETAEVH 298 Query: 126 VWDTNTLQTADVFNFEETVYSHHMSPVSTKHC--LVAVGTRGPKV--QLCDLKSGSCS-- 179 + D + V LV + G V +L G S Sbjct: 299 LLDLRKGNAHNTLEIVRPREKGVRYDVQMHGTSHLVILTNEGGAVNHKLLIAPRGQPSDW 358 Query: 180 -HILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVE 238 H+L H +++ S + R +Y++ ++W + S + ++ E Sbjct: 359 SHVLVDHSEDVFMESIAVRSNYLVVAGRRAGLTRIWTMMADSQDGVFKAGTGLREVVMEE 418 Query: 239 SANTAH 244 T H Sbjct: 419 PIFTVH 424 >6NAU-A nrPDB Length = 334 Score = 31.4 bits (69), Expect = 0.67, Method: Composition-based stats. Identities = 33/239 (13%), Positives = 70/239 (29%), Gaps = 30/239 (12%) Query: 110 HDTGMFTSSSFDKTLK----VWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVA----- 160 S+S+++ + D +T V E +S ++SP + + A Sbjct: 94 RHGRFVFSASYNQGCVSVTPLHDGLPGETITVVEGLEGCHSANISPDNRTLWVPALKQDR 153 Query: 161 ----VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 + L + + + + + P Y +S + +W++ Sbjct: 154 ICLFTLSDDGF-----LSAQEPAEVTTVEGAGPRHMVFHPNQQYGYCVNELNSSIDVWEL 208 Query: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNR---MRLWN 273 + G + + + A + T DG HL D + +++ Sbjct: 209 KDPKGNIECVQTLDMMPPDFSGVRWAA------DIHITPDGRHLYAC--DRTASIITVFS 260 Query: 274 SSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKG 332 S + L G + F + IAVY + + + KG Sbjct: 261 VSEDGSVLAVEG-YQPTETQPRGFNLDHSGKYLIAAGQKSHHIAVYDIVGEQGLLQEKG 318 >4IMM-A nrPDB Length = 399 Score = 31.0 bits (68), Expect = 0.99, Method: Composition-based stats. Identities = 36/252 (14%), Positives = 67/252 (26%), Gaps = 34/252 (13%) Query: 119 SFDKTLKVWDTNTLQTADVFNFEETVYSHH--MSPVSTKHCLVAVGTRGPKVQLCDLKSG 176 + T+ D N+ T + + S P++ V +G ++ D +G Sbjct: 168 TNSGTIFGLDINSGATVWQYATQVPNTSVRGMAKPLALDARTVLIGGADGRIHALDTMTG 227 Query: 177 SCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCL-ITLDQHNGKKSQ 235 + W+ R + + D +L D+ + L + Sbjct: 228 APV--------------WTRRVGLAMGSGEID---QLRDIDGTPTVVDHYLYAASYSGQL 270 Query: 236 AVESANTAHNGKVNGLCFTSDGLHLLTV----GTDNRMRLWNSSNGENTLVNYGKVCNNS 291 A T V+ L T L TD + +N GE N+ Sbjct: 271 AGFDMTTGRTMFVSELSSTKKLTTLADAVIGSSTDGDVVAFNRMTGEKLWENHDLKYRGL 330 Query: 292 KKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYS 351 + + + + QI + +N LY+ Sbjct: 331 TNPV------TIGTYIAVGDADGVVHILN--HQGQIISRANTKGALTNLTVINN--RLYA 380 Query: 352 GSRDCNILAWVP 363 S D + W Sbjct: 381 QSADGVVTVWQF 392 >3R3L-A nrPDB Length = 582 Score = 29.9 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 16/119 (13%), Positives = 39/119 (32%), Gaps = 13/119 (10%) Query: 62 GGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFD 121 G DGV+ ++D++N+ + + + V D G+ ++ + Sbjct: 155 AGRDGVVRVWDVKNAELLNNQFGTMPSLTLACLTKQGQVDLNDVVQALTDLGLIYTAKYP 214 Query: 122 KTLKVWDTNTLQTADVF-------NFEETVYSHHMS---PVSTKHCLVAVGTRGPKVQL 170 T D + L + + ++ S V C++ G +++ Sbjct: 215 NTS---DLDRLTQSHPILNMIDTKKSSLNISGYNFSLGAAVKAGACMLDGGNMLETIKV 270 Score = 28.7 bits (62), Expect = 4.5, Method: Composition-based stats. Identities = 23/164 (14%), Positives = 55/164 (33%), Gaps = 17/164 (10%) Query: 129 TNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRG----PKVQLCDLKSGSCSHILQG 184 + ++ V + + ++ S VS L+ R +++ + + + Sbjct: 24 CSNIKLQVVKDAQALLHGLDFSEVSNVQRLMRKQRRDDSDLKRLRDLNQAVNNLVELKST 83 Query: 185 HRQEILAV-SWSPRYDYILATASADSRVKLWDVRRASGCLITLDQH--NGKKSQAVESAN 241 ++ +L V + S LA D+ + + ++ +G + S Sbjct: 84 QQKSVLRVGTLSSDDLLTLAA----------DLEKLKSKVTRTERPLSSGVYMGNLSSQQ 133 Query: 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYG 285 + L ++G G D +R+W+ N E +G Sbjct: 134 LDQRRALLNLIGMTNGSQGSQAGRDGVVRVWDVKNAELLNNQFG 177 >5V8F-D nrPDB Length = 529 Score = 29.9 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 17/76 (22%), Positives = 30/76 (39%), Gaps = 3/76 (3%) Query: 171 CDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLW---DVRRASGCLITLD 227 +L +++ I V+ + +T S D+ +KLW DV+ L+ LD Sbjct: 408 FNLAYAEYEKMIKAINSRIPTVAPTTNVGTGQSTFSIDNTIKLWLKKDVKNVWENLVQLD 467 Query: 228 QHNGKKSQAVESANTA 243 K + + TA Sbjct: 468 FFTEKSAVGLRDNATA 483 >1RI6-A nrPDB Length = 343 Score = 29.5 bits (64), Expect = 2.4, Method: Composition-based stats. Identities = 34/214 (15%), Positives = 65/214 (30%), Gaps = 32/214 (14%) Query: 134 TADVFNFEETVYSHHMSPVSTKHCLVA---------VGTRGPKVQLCDLKSGSCSHILQG 184 DV + +S ++SP + + A + + D ++G Sbjct: 121 VVDVVEGLDGCHSANISPDNRTLWVPALKQDRICLFTVSDDGHLVAQDPAE---VTTVEG 177 Query: 185 HRQEILAVSWSPRYDYILATASADSRVKLWDVRRAS---GCLITLDQHNGKKSQAVESAN 241 + + P Y +S V +W+++ C+ TLD + N Sbjct: 178 --AGPRHMVFHPNEQYAYCVNELNSSVDVWELKDPHGNIECVQTLD---------MMPEN 226 Query: 242 TAHNGKVNGLCFTSDGLHLLTVGTDNR---MRLWNSSNGENTLVNYGKVCNNSKKGLKFT 298 + + T DG HL D + +++ S + L G + F Sbjct: 227 FSDTRWAADIHITPDGRHLYAC--DRTASLITVFSVSEDGSVLSKEG-FQPTETQPRGFN 283 Query: 299 VSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKG 332 V I+VY + + + KG Sbjct: 284 VDHSGKYLIAAGQKSHHISVYEIVGEQGLLHEKG 317 >2GBG-A nrPDB Length = 730 Score = 29.1 bits (63), Expect = 3.1, Method: Composition-based stats. Identities = 18/119 (15%), Positives = 33/119 (27%), Gaps = 16/119 (13%) Query: 62 GGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDT--------- 112 G + + + + S S T + + + V W D Sbjct: 221 GAVNPTVKFFIVNTDSLSSTTTTIPMQITAPASVTTGDHYLCDVAWVSEDRISLQWLRRI 280 Query: 113 ---GMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKV 168 + +DKT VW+ T Q + T + P + G+ K+ Sbjct: 281 QNYSVMAICDYDKTTLVWNCPTTQ--EHIETSATGWCGRFRPAEPH--FTSDGSSFYKI 335 >5SUM-A nrPDB Length = 468 Score = 29.1 bits (63), Expect = 3.3, Method: Composition-based stats. Identities = 8/29 (27%), Positives = 15/29 (51%) Query: 256 DGLHLLTVGTDNRMRLWNSSNGENTLVNY 284 DG +LL G D +R+++ + + Y Sbjct: 376 DGKYLLQGGLDRYVRIFDIKTNKMLVKVY 404 >3MWP-A nrPDB Length = 577 Score = 28.7 bits (62), Expect = 4.0, Method: Composition-based stats. Identities = 16/125 (12%), Positives = 39/125 (31%), Gaps = 13/125 (10%) Query: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMF 115 G G DGV+ ++D++N+ + + + D G+ Sbjct: 157 GNQGARAGRDGVVRVWDVKNAELLNNQFGTMPSLTLACLTKQGQVDLNDAVQALTDLGLI 216 Query: 116 TSSSFDKTLKVWDTNTLQTADVF-------NFEETVYSHHMS---PVSTKHCLVAVGTRG 165 ++ + T D + L + + ++ S V C++ G Sbjct: 217 YTAKYPNTS---DLDRLTQSHPILNMIDTKKSSLNISGYNFSLGAAVKAGACMLDGGNML 273 Query: 166 PKVQL 170 +++ Sbjct: 274 ETIKV 278 Score = 28.7 bits (62), Expect = 4.4, Method: Composition-based stats. Identities = 15/82 (18%), Positives = 28/82 (34%), Gaps = 2/82 (2%) Query: 206 SADSRVKLWDVRRASGCLITLDQH--NGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTV 263 S D + D+ + +I ++ G + S + + S G Sbjct: 104 SDDLLILAADLEKLKSKVIRTERPLSAGVYMGNLSSQQLDQRRALLNMIGMSGGNQGARA 163 Query: 264 GTDNRMRLWNSSNGENTLVNYG 285 G D +R+W+ N E +G Sbjct: 164 GRDGVVRVWDVKNAELLNNQFG 185 >5WLC-LK nrPDB Length = 575 Score = 28.7 bits (62), Expect = 4.1, Method: Composition-based stats. Identities = 13/100 (13%), Positives = 31/100 (31%), Gaps = 1/100 (1%) Query: 251 LCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFV 310 L +D + + +D ++ +N + L + V + + F + + V + Sbjct: 132 LGADTDESDIWILDSDKVVKKLQYNNSKP-LKTFTLVDGKDDEIVHFQILHQNGTLLVCI 190 Query: 311 PYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELY 350 + + T C F S+ + L Sbjct: 191 ITKQMVYIVDPSKRRPSTKYSFEISDAVACEFSSDGKYLL 230 >3K89-A nrPDB Length = 314 Score = 28.7 bits (62), Expect = 4.8, Method: Composition-based stats. Identities = 15/79 (18%), Positives = 27/79 (34%), Gaps = 12/79 (15%) Query: 108 YPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPK 167 +P F +S + +W + ++ N E T+ L+A G Sbjct: 28 HPQIRETFAEASEGAGVDLWALSQGGPEEMLNRTEY----------TQPALLAAGVA--V 75 Query: 168 VQLCDLKSGSCSHILQGHR 186 +L + G +L GH Sbjct: 76 WRLWTAQRGQRPALLAGHS 94 >4WJL-A nrPDB Length = 719 Score = 28.3 bits (61), Expect = 5.2, Method: Composition-based stats. Identities = 27/281 (9%), Positives = 74/281 (26%), Gaps = 43/281 (15%) Query: 4 FLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGG 63 F ++R + D + A +++ + IH + L+ VE + Sbjct: 61 FKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVL---- 116 Query: 64 SDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDV--HRYSVETVQWYPHDTGMFTSSSFD 121 + ++ + + E + + ++ Sbjct: 117 ---QYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLH 173 Query: 122 KTLKVWDTNTLQTADVFNFEETV--------YSHHMSPVSTKHCLVAVGTRGPKVQLCDL 173 + W + + +++ ++ + P ++ G P ++L + Sbjct: 174 SHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQMNPTIKLYVV 233 Query: 174 KSGSCSHI--------LQGHRQEILAVSWSPRYDYILATASADSRVKLW-----DVRRAS 220 +H + I V W ++ W ++ + Sbjct: 234 NLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVR----------WLNRAQNISILT 283 Query: 221 GCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLL 261 C T + K ++ + N + F+ DG Sbjct: 284 VCETTTGACSKKYEMTSDTWLSQQNEE---PVFSRDGSKFF 321 >3TMG-A nrPDB Length = 280 Score = 28.3 bits (61), Expect = 6.1, Method: Composition-based stats. Identities = 9/40 (22%), Positives = 17/40 (42%) Query: 325 EQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPS 364 + + G+ + +Q L SG D + +WVP+ Sbjct: 36 KVVFEKMGYNAEIFSVTTSIMYQYLASGKIDGTVSSWVPT 75 >1BWR-A nrPDB Length = 233 Score = 28.3 bits (61), Expect = 6.5, Method: Composition-based stats. Identities = 11/87 (12%), Positives = 24/87 (27%), Gaps = 2/87 (2%) Query: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHC 157 H+ + + P F +W + + V+ + T Sbjct: 53 HQCEIWRELFSPLHALNFGIGGDSTQHVLWRLENGELEHIRPKIVVVWVGSNNHGHTAEQ 112 Query: 158 LVAVGTRGPKVQLCDLKSGSCSHILQG 184 + G VQL + + ++ G Sbjct: 113 V--TGGIKAIVQLVNERQPQARVVVLG 137 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.113 0.300 Lambda K H 0.267 0.0347 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,483,851 Number of Sequences: 36641 Number of extensions: 479023 Number of successful extensions: 5936 Number of sequences better than 10.0: 164 Number of HSP's better than 10.0 without gapping: 232 Number of HSP's successfully gapped in prelim test: 59 Number of HSP's that attempted gapping in prelim test: 1342 Number of HSP's gapped (non-prelim): 1291 length of query: 396 length of database: 10,336,785 effective HSP length: 99 effective length of query: 297 effective length of database: 6,709,326 effective search space: 1992669822 effective search space used: 1992669822 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 59 (27.6 bits)