BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q12834 (499 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5G04-R nrPDB 1028 0.0 4GGA-A nrPDB 865 0.0 5LCW-Q nrPDB 771 0.0 4N14-A nrPDB 650 0.0 4AEZ-A nrPDB 347 5e-96 5L9T-R nrPDB 323 1e-88 5A31-R nrPDB 296 2e-80 4BH6-A nrPDB 294 7e-80 5M25-A nrPDB 98 7e-21 2H9P-A nrPDB 97 2e-20 6F3T-A nrPDB 95 9e-20 1VYH-C nrPDB 93 2e-19 6MZM-G nrPDB 93 3e-19 5MZH-A nrPDB 83 3e-16 5NNZ-B nrPDB 81 1e-15 3FM0-A nrPDB 73 2e-13 6QX9-4B nrPDB 71 1e-12 5K1B-B nrPDB 70 3e-12 4A11-B nrPDB 69 7e-12 6QX9-5O nrPDB 68 7e-12 5Y1U-A nrPDB 68 1e-11 4V8M-A7 nrPDB 67 1e-11 5FL8-q nrPDB 66 4e-11 6Q8F-A nrPDB 66 4e-11 5Z56-q nrPDB 65 5e-11 4LG8-A nrPDB 65 7e-11 4V6W-Ag nrPDB 65 8e-11 5UZ7-B nrPDB 64 1e-10 5OPT-p nrPDB 64 1e-10 5WYK-BB nrPDB 64 1e-10 5WLC-LO nrPDB 64 1e-10 5GAN-H nrPDB 64 1e-10 6HQA-B nrPDB 64 2e-10 5I2T-A nrPDB 64 2e-10 6GMH-W nrPDB 62 9e-10 5WYJ-BC nrPDB 61 1e-09 3C9C-A nrPDB 60 2e-09 6ID0-T nrPDB 60 2e-09 6HHQ-h nrPDB 60 3e-09 2YNP-A nrPDB 59 4e-09 6N9G-C nrPDB 59 4e-09 3MKQ-A nrPDB 58 7e-09 6G51-g nrPDB 58 8e-09 1NR0-A nrPDB 58 9e-09 6J6H-n nrPDB 58 1e-08 4BTS-AR nrPDB 55 5e-08 6EOJ-D nrPDB 55 6e-08 3DM0-A nrPDB 55 6e-08 4J0W-A nrPDB 52 4e-07 5OQL-L nrPDB 52 5e-07 5FVM-C nrPDB 52 5e-07 5Y88-O nrPDB 51 1e-06 5OQL-J nrPDB 51 1e-06 4YCZ-A nrPDB 51 1e-06 3JB9-g nrPDB 50 2e-06 5NZU-C nrPDB 50 2e-06 2HES-X nrPDB 50 3e-06 4V7E-Bg nrPDB 50 3e-06 2AQ5-A nrPDB 49 3e-06 5WJC-A nrPDB 49 4e-06 4L9O-A nrPDB 49 4e-06 3JB9-L nrPDB 49 6e-06 3CFV-B nrPDB 49 7e-06 6CHG-A nrPDB 49 7e-06 3JAP-g nrPDB 47 1e-05 5BJS-A nrPDB 47 2e-05 4XYI-A nrPDB 47 2e-05 5K0Y-T nrPDB 46 3e-05 6EMK-B nrPDB 44 2e-04 5YZG-W nrPDB 43 4e-04 6QDV-o nrPDB 42 5e-04 5XYI-g nrPDB 42 8e-04 2PM9-A nrPDB 42 0.001 6BX3-A nrPDB 41 0.001 4XFV-A nrPDB 40 0.002 5K19-A nrPDB 40 0.002 5OQL-X nrPDB 40 0.002 3JRO-A nrPDB 40 0.002 5OQL-d nrPDB 40 0.003 4G56-B nrPDB 39 0.004 5N4A-A nrPDB 39 0.004 4U1E-I nrPDB 39 0.005 5MWJ-A nrPDB 39 0.006 5WYJ-BE nrPDB 39 0.006 3JRP-A nrPDB 39 0.007 3ACP-A nrPDB 38 0.008 6CVZ-A nrPDB 38 0.011 5WLC-LN nrPDB 37 0.015 4BZK-B nrPDB 37 0.015 5OV3-A nrPDB 37 0.016 5WLC-LU nrPDB 37 0.021 6E29-D nrPDB 37 0.022 2P9P-C nrPDB 37 0.025 4OWR-A nrPDB 36 0.036 5WLC-SG nrPDB 36 0.042 5TF2-A nrPDB 36 0.043 5WLC-LV nrPDB 36 0.050 5WBU-D nrPDB 35 0.098 3BG0-A nrPDB 35 0.099 4J0X-A nrPDB 34 0.12 5CXB-B nrPDB 34 0.13 6ELZ-p nrPDB 34 0.15 6CHG-D nrPDB 34 0.16 4PSX-B nrPDB 34 0.17 5YZG-2 nrPDB 33 0.24 3ODT-A nrPDB 33 0.38 5CXC-A nrPDB 33 0.38 6BX3-B nrPDB 33 0.41 5MC6-j nrPDB 32 0.64 5WLC-LW nrPDB 32 0.74 2QTY-A nrPDB 32 0.78 3F3P-A nrPDB 32 0.84 3DWL-C nrPDB 32 0.92 5A9Q-7 nrPDB 31 0.99 5FA5-B nrPDB 31 1.1 1PI6-A nrPDB 31 1.3 5WLC-LH nrPDB 31 1.4 5M89-A nrPDB 30 1.9 6EM1-m nrPDB 30 2.4 6CB1-s nrPDB 30 2.5 6C0F-s nrPDB 30 2.6 4Y07-A nrPDB 30 2.7 5A9Q-2 nrPDB 30 3.0 1AKL-A nrPDB 30 3.4 5TJ8-A nrPDB 30 3.4 3JZG-A nrPDB 29 3.8 3JB9-S nrPDB 29 5.3 6O85-E nrPDB 28 6.2 3W15-A nrPDB 28 9.1 5LTD-A nrPDB 28 9.9 >5G04-R nrPDB Length = 499 Score = 1028 bits (2659), Expect = 0.0, Method: Compositional matrix adjust. Identities = 499/499 (100%), Positives = 499/499 (100%) Query: 1 MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTP 60 MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTP Sbjct: 1 MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTP 60 Query: 61 GKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNL 120 GKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNL Sbjct: 61 GKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNL 120 Query: 121 NGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPE 180 NGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPE Sbjct: 121 NGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPE 180 Query: 181 IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY 240 IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY Sbjct: 181 IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY 240 Query: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH 300 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH Sbjct: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH 300 Query: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 360 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA Sbjct: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 360 Query: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGF 420 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGF Sbjct: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGF 420 Query: 421 AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR Sbjct: 421 AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 Query: 481 REREKASAAKSSLIHQGIR 499 REREKASAAKSSLIHQGIR Sbjct: 481 REREKASAAKSSLIHQGIR 499 >4GGA-A nrPDB Length = 420 Score = 865 bits (2235), Expect = 0.0, Method: Compositional matrix adjust. Identities = 419/419 (100%), Positives = 419/419 (100%) Query: 81 PHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNA 140 PHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNA Sbjct: 2 PHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNA 61 Query: 141 PEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAV 200 PEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAV Sbjct: 62 PEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAV 121 Query: 201 ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKR 260 ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKR Sbjct: 122 ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKR 181 Query: 261 LRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD 320 LRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD Sbjct: 182 LRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD 241 Query: 321 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDR 380 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDR Sbjct: 242 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDR 301 Query: 381 HIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK 440 HIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK Sbjct: 302 HIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK 361 Query: 441 GHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR 499 GHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR Sbjct: 362 GHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR 420 >5LCW-Q nrPDB Length = 374 Score = 771 bits (1992), Expect = 0.0, Method: Compositional matrix adjust. Identities = 374/374 (100%), Positives = 374/374 (100%) Query: 126 EEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDY 185 EEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDY Sbjct: 1 EEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDY 60 Query: 186 YLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGT 245 YLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGT Sbjct: 61 YLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGT 120 Query: 246 SSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATL 305 SSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATL Sbjct: 121 SSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATL 180 Query: 306 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 365 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP Sbjct: 181 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 240 Query: 366 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQL 425 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQL Sbjct: 241 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQL 300 Query: 426 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREK 485 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREK Sbjct: 301 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREK 360 Query: 486 ASAAKSSLIHQGIR 499 ASAAKSSLIHQGIR Sbjct: 361 ASAAKSSLIHQGIR 374 >4N14-A nrPDB Length = 314 Score = 650 bits (1676), Expect = 0.0, Method: Compositional matrix adjust. Identities = 313/313 (100%), Positives = 313/313 (100%) Query: 165 CRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQ 224 CRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQ Sbjct: 2 CRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQ 61 Query: 225 PGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSG 284 PGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSG Sbjct: 62 PGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSG 121 Query: 285 SRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG 344 SRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG Sbjct: 122 SRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG 181 Query: 345 WVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCS 404 WVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCS Sbjct: 182 WVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCS 241 Query: 405 ILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAAD 464 ILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAAD Sbjct: 242 ILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAAD 301 Query: 465 ETLRLWRCFELDP 477 ETLRLWRCFELDP Sbjct: 302 ETLRLWRCFELDP 314 >4AEZ-A nrPDB Length = 401 Score = 347 bits (891), Expect = 5e-96, Method: Compositional matrix adjust. Identities = 185/408 (45%), Positives = 255/408 (62%), Gaps = 26/408 (6%) Query: 77 DRYIPHR-SAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSG 135 DR+IP R + A V S +S P A A GFD+ R+ Sbjct: 1 DRFIPSRPNTANAFVNSI---------SSDVPFDYSESVAEAC---GFDLNT----RVLA 44 Query: 136 KPQNAPEGYQ-NRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSS 194 +APE + L+ +++ P + R+ + P+R+LDAP I +DYYLNL+DWS+ Sbjct: 45 FKLDAPEAKKPVDLRTQHNRPQRPVVTPAKRRF-NTTPERVLDAPGIIDDYYLNLLDWSN 103 Query: 195 GNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWD 254 NV+AVAL+ +VY+W+A SG + L + ++ Y++SV W +G++L+VG + V ++D Sbjct: 104 LNVVAVALERNVYVWNADSGSVSALAETDE-STYVASVKWSHDGSFLSVGLGNGLVDIYD 162 Query: 255 VQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCG 314 V+ Q +LR M H ARVG LSWN ++LSSGSRSG IHHHDVR+A H + TL GHS EVCG Sbjct: 163 VESQTKLRTMAGHQARVGCLSWNRHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVCG 222 Query: 315 LRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATG 374 L W DG LASGGNDN+V +W + +P T T H AVKAVAWCPWQSN+LATG Sbjct: 223 LAWRSDGLQLASGGNDNVVQIWDARSS----IPKFTKTNHNAAVKAVAWCPWQSNLLATG 278 Query: 375 GGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPT-- 432 GGT D+ I WN +GA ++ VDA SQV S++WSPH KE++S HGF N L IW Y + Sbjct: 279 GGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSG 338 Query: 433 MAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 + K ++ H +RVL +SPDG +++AA+DE L+ WR ++ D +R Sbjct: 339 LTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHVKR 386 >5L9T-R nrPDB Length = 493 Score = 323 bits (827), Expect = 1e-88, Method: Compositional matrix adjust. Identities = 155/315 (49%), Positives = 208/315 (66%), Gaps = 5/315 (1%) Query: 160 SSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQL 219 S RK R I +P ++LDAPE+++D+YLNLVDWSS NVL+V L VYLWSA + + +L Sbjct: 163 SPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRL 222 Query: 220 LQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY 279 + G+ ++SV W + GN +AVGT VQ+WD K+L + H+ARVG+L+WN+ Sbjct: 223 CDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAE 282 Query: 280 ILSSGSRSGHIHHHDVRVAE-HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 LSSGSR I D+R L GH QEVCGL+W+ D + LASGGNDN + VW Sbjct: 283 QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVW-- 340 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 P+Q +T+H AVKA+AW P Q +LA+GGGT+DR IR WN +G L +D Sbjct: 341 --NHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT 398 Query: 399 HSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATV 458 SQVC++ WS H EL+S HG++QNQ+++WKYP++ +VA+L GH+ RVL L MSPDG + Sbjct: 399 GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAI 458 Query: 459 ASAAADETLRLWRCF 473 + A DETLR W F Sbjct: 459 VTGAGDETLRFWNVF 473 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 33/128 (25%), Positives = 65/128 (50%), Gaps = 12/128 (9%) Query: 357 AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELI 415 +V +V W + N++A G T ++IW+ +G LS ++ H+ +V ++ W+ ++L Sbjct: 231 SVTSVGWSE-RGNLVAVG--THKGFVQIWDAAAGKKLSMLEGHTARVGALAWNA--EQLS 285 Query: 416 SGHGFAQNQLVI---WKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 SG +++++++ + P + L+GH V L S D +AS D L +W Sbjct: 286 SG---SRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNH 342 Query: 473 FELDPARR 480 L P ++ Sbjct: 343 SSLSPVQQ 350 >5A31-R nrPDB Length = 386 Score = 296 bits (757), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 163/402 (40%), Positives = 241/402 (59%), Gaps = 31/402 (7%) Query: 76 GDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSG 135 GDR+IP R+ A V +F EN S K E A G + + + S Sbjct: 4 GDRFIPSRAGANWSV-NFHRINENGLAYSAL-LKNELLGA------GIEKVQKGLFTYSL 55 Query: 136 KPQNAPEGYQNRLKVLYSQKATPGSSRKTCR--YIPSLPDRILDAPEIRNDYYLNLVDWS 193 P YS S+K R I +P R+LDAP + +D+Y +L+DWS Sbjct: 56 SP--------------YSLSPVSNKSQKLLRSRQIAKVPYRVLDAPSLADDFYYSLIDWS 101 Query: 194 SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW 253 S +VLAVAL S++L ++GD++ L E EY +S++WI G++LAVG ++ V+++ Sbjct: 102 STDVLAVALGKSIFLTDNNTGDVVHLCDTEN--EY-TSLSWIGAGSHLAVGQANGLVEIY 158 Query: 254 DVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVC 313 DV ++K +R ++ H RV LSWN+++L+SGSR I H DVR+ + T+ H+QEVC Sbjct: 159 DVMKRKCIRTLSGHIDRVACLSWNNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVC 218 Query: 314 GLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLAT 373 GL+W LASGGNDN+V+V+ P+ TF +H+ AVKA+AW P + VLAT Sbjct: 219 GLKWNVADNKLASGGNDNVVHVYEGTSKS----PILTFDEHKAAVKAMAWSPHKRGVLAT 274 Query: 374 GGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTM 433 GGGT+DR ++IWNV + +S +D+ SQ+C+++WS + EL++ HG+++ L +W +M Sbjct: 275 GGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSM 334 Query: 434 AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFEL 475 +A LKGH+ RVL LT+S DG TV S A DETLR W+ F++ Sbjct: 335 DPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFDV 376 >4BH6-A nrPDB Length = 308 Score = 294 bits (752), Expect = 7e-80, Method: Compositional matrix adjust. Identities = 142/312 (45%), Positives = 212/312 (67%), Gaps = 7/312 (2%) Query: 163 KTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQM 222 K R I +P R+LDAP + +D+Y +L+DWSS +VLAVAL S++L ++GD++ L Sbjct: 2 KQFRQIAKVPYRVLDAPSLADDFYYSLIDWSSTDVLAVALGKSIFLTDNNTGDVVHLCDT 61 Query: 223 EQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILS 282 E EY +S++WI G++LAVG ++ V+++DV ++K +R ++ H RV LSWN+++L+ Sbjct: 62 EN--EY-TSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNHVLT 118 Query: 283 SGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE 342 SGSR I H DVR+ + T+ H+QEVCGL+W LASGGNDN+V+V+ Sbjct: 119 SGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKS 178 Query: 343 GGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV 402 P+ TF +H+ AVKA+AW P + VLATGGGT+DR ++IWNV + +S +D+ SQ+ Sbjct: 179 ----PILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQI 234 Query: 403 CSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAA 462 C+++WS + EL++ HG+++ L +W +M +A LKGH+ RVL LT+S DG TV S A Sbjct: 235 CNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGA 294 Query: 463 ADETLRLWRCFE 474 DETLR W+ F+ Sbjct: 295 GDETLRYWKLFD 306 >5M25-A nrPDB Length = 434 Score = 98.2 bits (243), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 77/278 (27%), Positives = 124/278 (44%), Gaps = 21/278 (7%) Query: 203 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLR 262 D + +W A G + + + G IS VAW + N L + +++WDV K L+ Sbjct: 166 DKLIKIWGAYDGKFEKTISGHKLG--ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLK 223 Query: 263 NMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD 320 + HS V ++N S ++ SGS + DV+ + + TL HS V + + D Sbjct: 224 TLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK-CLKTLPAHSDPVSAVHFNRD 282 Query: 321 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG-AVKAVAWCPWQSNVLATGGGTSD 379 G + S D L +W +A G+ L+T V V + P +LA T D Sbjct: 283 GSLIVSSSYDGLCRIWDTASGQC----LKTLIDDDNPPVSFVKFSPNGKYILA---ATLD 335 Query: 380 RHIRIWNVCSGACLSAVDAHSQVCSILWSPHY----KELISGHGFAQNQLVIWKYPTMAK 435 +++W+ G CL H +++ K ++SG N + IW T Sbjct: 336 NTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS--EDNLVYIWNLQTKEI 393 Query: 436 VAELKGHTSRVLSLTMSPDGATVASAAA--DETLRLWR 471 V +L+GHT V+S P +ASAA D+T++LW+ Sbjct: 394 VQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 431 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 48/168 (28%), Positives = 87/168 (51%), Gaps = 10/168 (5%) Query: 304 TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAW 363 TL+GH++ V ++++P+G LAS D L+ +W + G+ +T + H+ + VAW Sbjct: 140 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE----KTISGHKLGISDVAW 195 Query: 364 CPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQ 422 SN+L + + D+ ++IW+V SG CL + HS V ++P ++SG Sbjct: 196 SS-DSNLLVS--ASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS--FD 250 Query: 423 NQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 + IW T + L H+ V ++ + DG+ + S++ D R+W Sbjct: 251 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 298 Score = 36.2 bits (82), Expect = 0.038, Method: Compositional matrix adjust. Identities = 20/78 (25%), Positives = 40/78 (51%), Gaps = 1/78 (1%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEY-ISSVAWIKEGNYLAVGTSSAEVQLWDV 255 +LA LDN++ LW S G L+ + +Y I + + G ++ G+ V +W++ Sbjct: 329 ILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 388 Query: 256 QQQKRLRNMTSHSARVGS 273 Q ++ ++ + H+ V S Sbjct: 389 QTKEIVQKLQGHTDVVIS 406 Score = 35.8 bits (81), Expect = 0.046, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 27/44 (61%) Query: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474 P A L GHT V S+ SP+G +AS++AD+ +++W ++ Sbjct: 133 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD 176 >2H9P-A nrPDB Length = 329 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 77/278 (27%), Positives = 124/278 (44%), Gaps = 21/278 (7%) Query: 203 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLR 262 D + +W A G + + + G IS VAW + N L + +++WDV K L+ Sbjct: 61 DKLIKIWGAYDGKFEKTISGHKLG--ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLK 118 Query: 263 NMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD 320 + HS V ++N S ++ SGS + DV+ + + TL HS V + + D Sbjct: 119 TLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK-CLKTLPAHSDPVSAVHFNRD 177 Query: 321 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG-AVKAVAWCPWQSNVLATGGGTSD 379 G + S D L +W +A G+ L+T V V + P +LA T D Sbjct: 178 GSLIVSSSYDGLCRIWDTASGQ----CLKTLIDDDNPPVSFVKFSPNGKYILA---ATLD 230 Query: 380 RHIRIWNVCSGACLSAVDAHSQVCSILWSPHY----KELISGHGFAQNQLVIWKYPTMAK 435 +++W+ G CL H +++ K ++SG N + IW T Sbjct: 231 NTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS--EDNLVYIWNLQTKEI 288 Query: 436 VAELKGHTSRVLSLTMSPDGATVASAAA--DETLRLWR 471 V +L+GHT V+S P +ASAA D+T++LW+ Sbjct: 289 VQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 326 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 48/168 (28%), Positives = 87/168 (51%), Gaps = 10/168 (5%) Query: 304 TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAW 363 TL+GH++ V ++++P+G LAS D L+ +W + G+ +T + H+ + VAW Sbjct: 35 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE----KTISGHKLGISDVAW 90 Query: 364 CPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQ 422 SN+L + + D+ ++IW+V SG CL + HS V ++P ++SG Sbjct: 91 SS-DSNLLVS--ASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS--FD 145 Query: 423 NQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 + IW T + L H+ V ++ + DG+ + S++ D R+W Sbjct: 146 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 193 Score = 36.2 bits (82), Expect = 0.034, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 27/44 (61%) Query: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474 P A L GHT V S+ SP+G +AS++AD+ +++W ++ Sbjct: 28 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD 71 Score = 36.2 bits (82), Expect = 0.036, Method: Compositional matrix adjust. Identities = 20/78 (25%), Positives = 40/78 (51%), Gaps = 1/78 (1%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEY-ISSVAWIKEGNYLAVGTSSAEVQLWDV 255 +LA LDN++ LW S G L+ + +Y I + + G ++ G+ V +W++ Sbjct: 224 ILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 283 Query: 256 QQQKRLRNMTSHSARVGS 273 Q ++ ++ + H+ V S Sbjct: 284 QTKEIVQKLQGHTDVVIS 301 >6F3T-A nrPDB Length = 608 Score = 94.7 bits (234), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 70/231 (30%), Positives = 116/231 (50%), Gaps = 18/231 (7%) Query: 251 QLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATLSG 307 ++ D + L+ + HS V S++ +Y+LSS S G + ++ V G Sbjct: 334 RIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSS-SEDGTVRLWSLQTFTCLVG-YKG 391 Query: 308 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQ 367 H+ V +++P G + SGG+D + +W + + PL+ F H V + P Sbjct: 392 HNYPVWDTQFSPYGYYFVSGGHDRVARLWAT----DHYQPLRIFAGHLADVNCTRFHP-N 446 Query: 368 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLV 426 SN +ATG ++DR +R+W+V +G C+ H + S+ +SP+ + L +G +++ Sbjct: 447 SNYVATG--SADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGA--TDGRVL 502 Query: 427 IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW---RCFE 474 +W V ELKGHT V SL S DG +AS + D T+RLW + FE Sbjct: 503 LWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFE 553 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 37/100 (37%), Positives = 54/100 (54%), Gaps = 3/100 (3%) Query: 239 NYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVR 296 NY+A G++ V+LWDV +R T H + SL++ N L++G+ G + D+ Sbjct: 448 NYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIG 507 Query: 297 VAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 336 V L GH+ VC LR++ DG LASG DN V +W Sbjct: 508 HGL-MVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 546 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 25/96 (26%), Positives = 43/96 (44%), Gaps = 12/96 (12%) Query: 375 GGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA 434 GG +D +R+W+V L +V S + L +++ I T + Sbjct: 295 GGFADSTVRVWSVTPKK-LRSVKQASDLS--LIDKESDDVLER---------IMDEKTAS 342 Query: 435 KVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 ++ L GH+ V + SPD + S++ D T+RLW Sbjct: 343 ELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLW 378 Score = 29.6 bits (65), Expect = 2.8, Method: Compositional matrix adjust. Identities = 38/171 (22%), Positives = 55/171 (32%), Gaps = 21/171 (12%) Query: 310 QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 369 Q + + D +A G D+ V VW P K + S+ Sbjct: 279 QGLTAVDVTDDSSLIAGGFADSTVRVWSVTP------------------KKLRSVKQASD 320 Query: 370 VLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIW 428 + + D RI + + + L + HS V +SP L+S + +W Sbjct: 321 LSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSS--EDGTVRLW 378 Query: 429 KYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPAR 479 T + KGH V SP G S D RLW P R Sbjct: 379 SLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR 429 >1VYH-C nrPDB Length = 410 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 75/296 (25%), Positives = 130/296 (43%), Gaps = 29/296 (9%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256 +++ + D ++ +W +GD + L+ + + +++ G LA ++ ++LWD Q Sbjct: 123 MVSASEDATIKVWDYETGDFERTLKGHT--DSVQDISFDHSGKLLASCSADMTIKLWDFQ 180 Query: 257 QQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCG 314 + +R M H V S+S N + S SR I +V+ + V T +GH + V Sbjct: 181 GFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTG-YCVKTFTGHREWVRM 239 Query: 315 LRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP---WQSNVL 371 +R DG +AS ND V VW A E +H+ V+ ++W P + S Sbjct: 240 VRPNQDGTLIASCSNDQTVRVWVVATKECK----AELREHRHVVECISWAPESSYSSISE 295 Query: 372 ATGG--------------GTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELIS 416 ATG G+ D+ I++W+V +G CL + H V +L+ K ++S Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILS 355 Query: 417 GHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 L +W Y + L H V SL V + + D+T+++W C Sbjct: 356 CAD--DKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWEC 409 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 39/167 (23%), Positives = 73/167 (43%), Gaps = 10/167 (5%) Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 LSGH V + + P + S D + VW G+ +T H +V+ +++ Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFE----RTLKGHTDSVQDISF- 158 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQN 423 +LA+ ++D I++W+ C+ + H V S+ P+ ++S Sbjct: 159 DHSGKLLASC--SADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSAS--RDK 214 Query: 424 QLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 + +W+ T V GH V + + DG +AS + D+T+R+W Sbjct: 215 TIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 27/130 (20%), Positives = 60/130 (46%), Gaps = 8/130 (6%) Query: 345 WVPL----QTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS 400 W+P + H+ V V + P S +++ + D I++W+ +G + H+ Sbjct: 94 WIPRPPEKYALSGHRSPVTRVIFHPVFSVMVS---ASEDATIKVWDYETGDFERTLKGHT 150 Query: 401 QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVAS 460 + H +L++ A + +W + + + GH V S+++ P+G + S Sbjct: 151 DSVQDISFDHSGKLLASCS-ADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVS 209 Query: 461 AAADETLRLW 470 A+ D+T+++W Sbjct: 210 ASRDKTIKMW 219 >6MZM-G nrPDB Length = 800 Score = 92.8 bits (229), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 57/172 (33%), Positives = 91/172 (52%), Gaps = 13/172 (7%) Query: 307 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW 366 GH+ V +++P G + SGG+D + +W + + PL+ F H V + P Sbjct: 583 GHNYPVWDTQFSPYGYYFVSGGHDRVARLWAT----DHYQPLRIFAGHLADVNCTRFHP- 637 Query: 367 QSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQL 425 SN +ATG ++DR +R+W+V +G C+ H + S+ +SP+ + L +G ++ Sbjct: 638 NSNYVATG--SADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGA--TDGRV 693 Query: 426 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW---RCFE 474 ++W V ELKGHT V SL S DG +AS + D T+RLW + FE Sbjct: 694 LLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFE 745 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 37/100 (37%), Positives = 54/100 (54%), Gaps = 3/100 (3%) Query: 239 NYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVR 296 NY+A G++ V+LWDV +R T H + SL++ N L++G+ G + D+ Sbjct: 640 NYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIG 699 Query: 297 VAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 336 V L GH+ VC LR++ DG LASG DN V +W Sbjct: 700 HG-LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738 Score = 28.9 bits (63), Expect = 5.7, Method: Compositional matrix adjust. Identities = 16/53 (30%), Positives = 18/53 (33%) Query: 427 IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPAR 479 +W T + KGH V SP G S D RLW P R Sbjct: 569 LWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR 621 >5MZH-A nrPDB Length = 452 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 65/276 (23%), Positives = 126/276 (45%), Gaps = 20/276 (7%) Query: 203 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK-EGNYLAVGTSSAEVQLWDVQQQKRL 261 D + +W+ +G+ ++ +E + ++A+ G+ + G+ +LWD + Sbjct: 115 DRTCKVWNTFTGE--EVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLY 172 Query: 262 RNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP 319 + H + LS+N S I+++GS DV + ATL+GH E+ L + Sbjct: 173 YTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQER-ATLAGHRAEIVSLGFNT 231 Query: 320 DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSD 379 G + +G D+ +W G+ + + H+G V + + + V++ G+ D Sbjct: 232 GGDLIVTGSFDHDSRLWDVRTGQ----CVHVLSGHRGEVSSTQFNYAGTLVVS---GSID 284 Query: 380 RHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAE 438 R+W+V SG CLS H+ +V + + +++S +L Y T+ V + Sbjct: 285 CTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSARL----YHTLTGVCQ 340 Query: 439 --LKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 L GH + + +P G + +A++D+T RLW C Sbjct: 341 HTLVGHEGEISKVAFNPQGTRLITASSDKTCRLWDC 376 Score = 74.7 bits (182), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 62/278 (22%), Positives = 120/278 (43%), Gaps = 15/278 (5%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256 ++ + D + LW A +G + L+ Q I +++ + +A G+ +LWDV+ Sbjct: 152 IVTGSFDKTCKLWDAYTGQLYYTLKGHQTE--IVCLSFNPQSTIIATGSMDNTAKLWDVE 209 Query: 257 QQKRLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCG 314 + + H A + SL +N+ ++ +GS DVR + V LSGH EV Sbjct: 210 TGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQC-VHVLSGHRGEVSS 268 Query: 315 LRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATG 374 ++ G + SG D +W G L H V VA+ + +++ Sbjct: 269 TQFNYAGTLVVSGSIDCTSRLWDVRSGR----CLSVKQGHTDEVLDVAFDAAGTKMVS-- 322 Query: 375 GGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTM 433 ++D R+++ +G C + H ++ + ++P LI+ + +W T Sbjct: 323 -ASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLITAS--SDKTCRLWDCDTG 379 Query: 434 AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 + L+GHT + S + +G + + + D T R+W+ Sbjct: 380 ECLQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCRIWK 417 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 29/124 (23%), Positives = 57/124 (45%), Gaps = 7/124 (5%) Query: 376 GTSDRHIRIWNVCSGACLSAVDAHSQVC-SILWSPHYKELISGHGFAQNQLVIWKYPTMA 434 G+ DR ++WN +G + ++ H V +I ++ Y + I F + +W T Sbjct: 112 GSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKT-CKLWDAYTGQ 170 Query: 435 KVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLI 494 LKGH + ++ L+ +P +A+ + D T +LW D +ER + ++ ++ Sbjct: 171 LYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLW-----DVETGQERATLAGHRAEIV 225 Query: 495 HQGI 498 G Sbjct: 226 SLGF 229 >5NNZ-B nrPDB Length = 415 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 75/322 (23%), Positives = 137/322 (42%), Gaps = 23/322 (7%) Query: 158 PGSSRKTCRYIPSLPDRILDAPE-IRNDYYLNLVDWSSGNVLAV-ALDNSVYLWSASSGD 215 GS +TC+ + L+ E RN Y + G+ +A + D + LWS +G Sbjct: 109 TGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK 168 Query: 216 ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS 275 + I +++ + +A G+ +LWD+Q + + + HSA + SLS Sbjct: 169 CYHTFRGHTA--EIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLS 226 Query: 276 WNSYILSSGSR--SGHIHHHDV---RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGND 330 +N +SG R +G H V V L GH E+ + D + +G D Sbjct: 227 FN----TSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMD 282 Query: 331 NLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG 390 +W + G+ + T T H + + + ++AT ++D RI++ + Sbjct: 283 KTCKLWDATNGK----CVATLTGHDDEILDSCF-DYTGKLIAT--ASADGTARIFSAATR 335 Query: 391 ACLSAVDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSL 449 C++ ++ H ++ I ++P L++G + IW T + L+GHT + S Sbjct: 336 KCIAKLEGHEGEISKISFNPQGNHLLTGS--SDKTARIWDAQTGQCLQVLEGHTDEIFSC 393 Query: 450 TMSPDGATVASAAADETLRLWR 471 + G V + + D T R+WR Sbjct: 394 AFNYKGNIVITGSKDNTCRIWR 415 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 67/298 (22%), Positives = 118/298 (39%), Gaps = 56/298 (18%) Query: 203 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK-EGNYLAVGTSSAEVQLWDVQQQKRL 261 D + LW +SG+ L L+ + Y ++A+ G+ +A G+ +LW V+ K Sbjct: 113 DRTCKLWDTASGEELNTLEGHRNVVY--AIAFNNPYGDKIATGSFDKTCKLWSVETGKCY 170 Query: 262 RNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP 319 H+A + LS+N S ++++GS D++ E V TL GHS E+ L + Sbjct: 171 HTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEE-VYTLRGHSAEIISLSFNT 229 Query: 320 DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSD 379 G + +G D+ V VW + G + H + + ++ W +++ TG + D Sbjct: 230 SGDRIITGSFDHTVVVWDADTGR----KVNILIGHCAEISSASF-NWDCSLILTG--SMD 282 Query: 380 RHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL 439 + ++W+ +G C VA L Sbjct: 283 KTCKLWDATNGKC-------------------------------------------VATL 299 Query: 440 KGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 GH +L G +A+A+AD T R++ + E + +K S QG Sbjct: 300 TGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQG 357 >3FM0-A nrPDB Length = 345 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 53/169 (31%), Positives = 83/169 (49%), Gaps = 9/169 (5%) Query: 307 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW 366 GH + V + W+P G +LAS D +W + + + T H+ VK+VAW P Sbjct: 59 GHQRTVRKVAWSPCGNYLASASFDATTCIWKK--NQDDFECVTTLEGHENEVKSVAWAP- 115 Query: 367 QSNVLATGGGTSDRHIRIWNVCSG---ACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQ 422 N+LAT + D+ + +W V C+S +++H+Q V ++W P + L S Sbjct: 116 SGNLLATC--SRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDT 173 Query: 423 NQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 +L + A L+GH S V SL P G +AS + D T+R+WR Sbjct: 174 VKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWR 222 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 62/217 (28%), Positives = 92/217 (42%), Gaps = 27/217 (12%) Query: 190 VDWS-SGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247 V WS GN LA A D + +W + D + +E + SVAW GN LA + Sbjct: 67 VAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRD 126 Query: 248 AEVQLWDVQQQKRLRN---MTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHH- 301 V +W+V ++ + SH+ V + W + +L+S S + + R E Sbjct: 127 KSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY--REEEDDW 184 Query: 302 --VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS-APG----------EGGWVPL 348 ATL GH V L + P G+ LAS +D V +W PG + W + Sbjct: 185 VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244 Query: 349 QTFTQ-HQGAVKAVAWCPWQSNVLATGGGTSDRHIRI 384 T + H + +AWC + LAT G D IR+ Sbjct: 245 CTLSGFHSRTIYDIAWCQ-LTGALATACG--DDAIRV 278 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 77/312 (24%), Positives = 134/312 (42%), Gaps = 40/312 (12%) Query: 194 SGNVLA-VALDNSVYLWSASSGD--ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEV 250 +G +LA D + +W + GD I + + E + VAW GNYLA + A Sbjct: 27 AGTLLASCGGDRRIRIW-GTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATT 85 Query: 251 QLWDVQQQ--KRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHH--VAT 304 +W Q + + + H V S++W + +L++ SR + +V + + V+ Sbjct: 86 CIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSV 145 Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 L+ H+Q+V + W P LAS D+ V ++ E WV T H+ V ++A+ Sbjct: 146 LNSHTQDVKHVVWHPSQELLASASYDDTVKLYREE--EDDWVCCATLEGHESTVWSLAFD 203 Query: 365 PWQSNVLATGGGTSDRHIRIWN----------VCSGA-----CLSAVDA-HSQ-VCSILW 407 P LA+ + DR +RIW CSG+ C+ + HS+ + I W Sbjct: 204 P-SGQRLAS--CSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAW 260 Query: 408 SPHYKELISGHG------FAQNQLVIWKYPTMAKVAEL-KGHTSRVLSLTMSP-DGATVA 459 L + G F ++ + PT + A L + H+ V + +P + +A Sbjct: 261 CQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLA 320 Query: 460 SAAADETLRLWR 471 S + D + W+ Sbjct: 321 SCSDDGEVAFWK 332 >6QX9-4B nrPDB Length = 522 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 55/234 (23%), Positives = 98/234 (41%), Gaps = 14/234 (5%) Query: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVA 298 LA + V+LW + + + ++ H+ RV + W+ L + D+ A Sbjct: 296 LASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLE-A 354 Query: 299 EHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAV 358 + + GHS V + + DG +GG D VW G + +G + Sbjct: 355 QEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTG-------RCIMFLEGHL 407 Query: 359 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSP-HYKELIS 416 K + + N G+ D ++W++ C+ + AH V + + P H L++ Sbjct: 408 KEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLT 467 Query: 417 GHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 G N IW +P + + L GH +V+ L +S DG +A+ + D T +LW Sbjct: 468 GA--YDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 29.3 bits (64), Expect = 4.5, Method: Compositional matrix adjust. Identities = 14/52 (26%), Positives = 26/52 (50%), Gaps = 8/52 (15%) Query: 427 IWKYPTMAKVAELKGHTSRV--------LSLTMSPDGATVASAAADETLRLW 470 +W P + L+GH + V ++++ P +AS AAD +++LW Sbjct: 257 LWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLW 308 >5K1B-B nrPDB Length = 677 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 53/186 (28%), Positives = 88/186 (47%), Gaps = 20/186 (10%) Query: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 360 ++A++ H+ V + +G+ L S +D V VW + G + T H+ VKA Sbjct: 67 YIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKG----FCMSTLRTHKDYVKA 122 Query: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSI------LWSPHYKEL 414 +A+ + V + G DR I +W+V + L+A + S+ ++S +L Sbjct: 123 LAYAKDKELVASAG---LDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQL 179 Query: 415 --ISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW-- 470 I G + L +W T AK+ +LKGHT V +L ++ DG S ++D T+RLW Sbjct: 180 GTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL 239 Query: 471 ---RCF 473 RC Sbjct: 240 GQQRCI 245 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 40/191 (20%), Positives = 79/191 (41%), Gaps = 19/191 (9%) Query: 222 MEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSY 279 ME ++++ + G L +S V++W+ + + + +H V +L++ + Sbjct: 71 MEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKE 130 Query: 280 ILSSGSRSGHIHHHDVRV-----AEHHVAT---LSGHSQEVCGLRWAPDGRHLASGGNDN 331 +++S I DV A ++ T LSG+ + L G + SG + Sbjct: 131 LVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEK 190 Query: 332 LVNVW-PSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG 390 ++ VW P + L H VKA+ + L+ G+SD IR+W++ Sbjct: 191 VLRVWDPRTCAK-----LMKLKGHTDNVKALLLNRDGTQCLS---GSSDGTIRLWSLGQQ 242 Query: 391 ACLSAVDAHSQ 401 C++ H + Sbjct: 243 RCIATYRVHDE 253 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 18/81 (22%), Positives = 39/81 (48%), Gaps = 2/81 (2%) Query: 218 QLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN 277 +L++++ + + ++ ++G G+S ++LW + QQ+ + H V +L N Sbjct: 202 KLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVN 261 Query: 278 SYI--LSSGSRSGHIHHHDVR 296 + SG R I+ D+R Sbjct: 262 DAFTHVYSGGRDRKIYCTDLR 282 >4A11-B nrPDB Length = 408 Score = 68.6 bits (166), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 71/301 (23%), Positives = 132/301 (43%), Gaps = 36/301 (11%) Query: 143 GYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDW---SSGNVLA 199 G + + VLY + + S TC+ + S+ D P++ Y + V W +G + Sbjct: 62 GGSDGVIVLYDLENSSRQSYYTCKAVCSIGR---DHPDVHR-YSVETVQWYPHDTGMFTS 117 Query: 200 VALDNSVYLWSASSGDILQLLQMEQP--GEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQ 257 + D ++ +W ++ + E+ ++S V+ + +AVGT +VQL D++ Sbjct: 118 SSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVS--TKHCLVAVGTRGPKVQLCDLKS 175 Query: 258 QKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATL--------- 305 + H + ++SW+ YIL++ S + DVR A + TL Sbjct: 176 GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQ 235 Query: 306 ------SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPL-QTFTQHQGAV 358 + H+ +V GL + DG HL + G DN + +W S+ GE V + + + Sbjct: 236 AVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGL 295 Query: 359 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV--CSILWSPHYKELIS 416 K C S + G++ I ++ V SG ++ + H + C + S +++EL S Sbjct: 296 KFTVSCGCSSEFVFVPYGST---IAVYTVYSGEQITMLKGHYKTVDCCVFQS-NFQELYS 351 Query: 417 G 417 G Sbjct: 352 G 352 Score = 35.0 bits (79), Expect = 0.069, Method: Compositional matrix adjust. Identities = 49/254 (19%), Positives = 87/254 (34%), Gaps = 56/254 (22%) Query: 237 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVR 296 EG Y+ G S + L+D++ R T + + S G +H + V Sbjct: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKA-----------VCSIGRDHPDVHRYSVE 103 Query: 297 VAEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQT--FTQ 353 ++W P D S D + VW + LQT Sbjct: 104 T-----------------VQWYPHDTGMFTSSSFDKTLKVWDTNT-------LQTADVFN 139 Query: 354 HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYK 412 + V + P + GT +++ ++ SG+C + H Q + ++ WSP Y Sbjct: 140 FEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRY- 198 Query: 413 ELISGHGFAQNQLVIWKY----------------PTMAKVAELKGHTSRVLSLTMSPDGA 456 + I A +++ +W + A + H +V L + DG Sbjct: 199 DYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGL 258 Query: 457 TVASAAADETLRLW 470 + + D +RLW Sbjct: 259 HLLTVGTDNRMRLW 272 >6QX9-5O nrPDB Length = 357 Score = 68.2 bits (165), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 48/179 (26%), Positives = 76/179 (42%), Gaps = 10/179 (5%) Query: 303 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 ATL GHS V L + DG L S D V VW S GE + +G V Sbjct: 103 ATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGE-------RVKRLKGHTSFVN 155 Query: 363 WC-PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFA 421 C P + G+ D +++W++ A + QV ++ ++ ++ISG Sbjct: 156 SCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGG--I 213 Query: 422 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 N + +W ++GH V L++S +G+ + S A D T+R+W P R Sbjct: 214 DNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKER 272 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 60/289 (20%), Positives = 125/289 (43%), Gaps = 25/289 (8%) Query: 194 SGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 252 +G+ LA A D + LW+ GD ++ + + + +G+ L ++ V + Sbjct: 77 NGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAV 135 Query: 253 WDVQQQKRLRNMTSHSARVGSL---SWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHS 309 WD + +R++ + H++ V S ++ +GS G + D+R + + T ++ Sbjct: 136 WDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIR-KKAAIQTFQ-NT 193 Query: 310 QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 369 +V + + + SGG DN + VW + + T H +V ++ S Sbjct: 194 YQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTY----TMRGHADSVTGLSLSSEGSY 249 Query: 370 VLATGGGTSDRHIRIWNVCSGA----CLSAV--DAHSQVCSIL---WSPHYKELISGHGF 420 +L+ D +R+W+V A C+ + H+ ++L WSP ++ +G Sbjct: 250 LLSNA---MDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGS-- 304 Query: 421 AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRL 469 A + +W + + +L GH + + PD + SA++D+ L + Sbjct: 305 ADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353 Score = 35.0 bits (79), Expect = 0.071, Method: Compositional matrix adjust. Identities = 16/47 (34%), Positives = 28/47 (59%), Gaps = 1/47 (2%) Query: 425 LVIWK-YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 +++W Y A LKGH+ V+ L + DG+ + SA+ D+T+ +W Sbjct: 90 ILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVW 136 Score = 32.7 bits (73), Expect = 0.40, Method: Compositional matrix adjust. Identities = 14/40 (35%), Positives = 20/40 (50%) Query: 434 AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 A + L GH V P+G+T+ASA D + LW + Sbjct: 57 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY 96 >5Y1U-A nrPDB Length = 456 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 54/202 (26%), Positives = 87/202 (43%), Gaps = 11/202 (5%) Query: 305 LSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWP--SAPGEGGWVPLQT-FTQHQGAVKA 360 L GH +E GL W P+ HL S +D+ + +W + P EG V +T FT H V+ Sbjct: 204 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 263 Query: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS---AVDAHSQVCSILWSPHYKELISG 417 V+W ++ G D+ + IW+ S +VDAH+ + L Y E I Sbjct: 264 VSWHLLHESLF--GSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 321 Query: 418 HGFAQNQLVIWKYPTMA-KVAELKGHTSRVLSLTMSPDGATV-ASAAADETLRLWRCFEL 475 G A + +W + K+ + H + + SP T+ AS+ D L +W ++ Sbjct: 322 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 381 Query: 476 DPARRREREKASAAKSSLIHQG 497 + E + + IH G Sbjct: 382 GEEQSPEDAEDGPPELLFIHGG 403 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 40/157 (25%), Positives = 77/157 (49%), Gaps = 15/157 (9%) Query: 194 SGNVLAVALDNSVYLWSASS----GDILQLLQMEQP-GEYISSVAW--IKEGNYLAVGTS 246 SG++L+ + D+++ LW S+ G ++ + + V+W + E + +V Sbjct: 221 SGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVA-D 279 Query: 247 SAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWNSY---ILSSGSRSGHIHHHDVRVAEH 300 ++ +WD + K ++ +H+A V LS+N Y IL++GS + D+R + Sbjct: 280 DQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL 339 Query: 301 HVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW 336 + + H E+ ++W+P LAS G D +NVW Sbjct: 340 KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 376 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 40/174 (22%), Positives = 71/174 (40%), Gaps = 38/174 (21%) Query: 304 TLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 ++ H+ EV L + P LA+G D V +W + + L +F H+ + V Sbjct: 299 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK---LKLHSFESHKDEIFQVQ 355 Query: 363 WCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAVDAHSQVCSILWSPHYKELISGHGFA 421 W P +LA+ G +DR + +W++ G S DA P EL+ HG Sbjct: 356 WSPHNETILASSG--TDRRLNVWDLSKIGEEQSPEDAED-------GP--PELLFIHG-- 402 Query: 422 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLWRCFE 474 GHT+++ + +P+ + S + D +++W+ E Sbjct: 403 -------------------GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 437 >4V8M-A7 nrPDB Length = 318 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 52/169 (30%), Positives = 81/169 (47%), Gaps = 11/169 (6%) Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 L GHS V + + +G S D+ + +W G+ + F H V +VA+ Sbjct: 63 LEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQY----KFLGHTKDVLSVAFS 118 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVD--AHSQ-VCSILWSPHYKELISGHGFA 421 P +++ G D +R+WNV G C+ + AH+ V + +SP + G Sbjct: 119 PDNRQIVSGG---RDNALRVWNV-KGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGW 174 Query: 422 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 N + +W T V +LKGHT+ V S+T+SPDG+ AS+ D RLW Sbjct: 175 DNLVKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLW 223 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 61/261 (23%), Positives = 113/261 (43%), Gaps = 21/261 (8%) Query: 221 QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NS 278 ++E ++S VA GN+ + ++LW++Q + H+ V S+++ ++ Sbjct: 62 RLEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDN 121 Query: 279 YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP--DGRHLASGGNDNLVNVW 336 + SG R + +V+ H + H+ V +R++P D + SGG DNLV VW Sbjct: 122 RQIVSGGRDNALRVWNVKGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVW 181 Query: 337 PSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV 396 A G + H V +V P ++ A+ D R+W++ G LS + Sbjct: 182 DLATGR----LVTDLKGHTNYVTSVTVSP-DGSLCASS--DKDGVARLWDLTKGEALSEM 234 Query: 397 DAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL-------KGHTSRVLSL 449 A + + I +SP+ + + + + I+ + EL K +S+ Sbjct: 235 AAGAPINQICFSPNRYWMCAA---TEKGIRIFDLENKDIIVELAPEHQGSKKIVPECVSI 291 Query: 450 TMSPDGATVASAAADETLRLW 470 S DG+T+ S D +R+W Sbjct: 292 AWSADGSTLYSGYTDNVIRVW 312 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 35/148 (23%), Positives = 65/148 (43%), Gaps = 12/148 (8%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256 +++ DN V +W ++G ++ L+ Y++SV +G+ A +LWD+ Sbjct: 169 IVSGGWDNLVKVWDLATGRLVTDLKGHT--NYVTSVTVSPDGSLCASSDKDGVARLWDLT 226 Query: 257 QQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQ---- 310 + + L M + A + + + N Y + + + G I D+ + V H Sbjct: 227 KGEALSEMAA-GAPINQICFSPNRYWMCAATEKG-IRIFDLENKDIIVELAPEHQGSKKI 284 Query: 311 --EVCGLRWAPDGRHLASGGNDNLVNVW 336 E + W+ DG L SG DN++ VW Sbjct: 285 VPECVSIAWSADGSTLYSGYTDNVIRVW 312 Score = 35.0 bits (79), Expect = 0.081, Method: Compositional matrix adjust. Identities = 48/205 (23%), Positives = 87/205 (42%), Gaps = 18/205 (8%) Query: 146 NRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVAL--D 203 +R K L S P C Y LPDR L+ + +++ V S+ AV+ D Sbjct: 35 SRDKTLLSWGPNPDRHSSECSY--GLPDRRLEG----HSAFVSDVALSNNGNFAVSASWD 88 Query: 204 NSVYLWSASSGDI-LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQ-KRL 261 +S+ LW+ +G + L + + SVA+ + + G +++W+V+ + Sbjct: 89 HSLRLWNLQNGQCQYKFLGHTKD---VLSVAFSPDNRQIVSGGRDNALRVWNVKGECMHT 145 Query: 262 RNMTSHSARVGSL----SWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRW 317 + +H+ V + S ++ ++ SG + D+ V L GH+ V + Sbjct: 146 LSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRL-VTDLKGHTNYVTSVTV 204 Query: 318 APDGRHLASGGNDNLVNVWPSAPGE 342 +PDG AS D + +W GE Sbjct: 205 SPDGSLCASSDKDGVARLWDLTKGE 229 >5FL8-q nrPDB Length = 515 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 80/330 (24%), Positives = 129/330 (39%), Gaps = 57/330 (17%) Query: 190 VDWS-SGNVLAV-ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAW-----IKEGNY-- 240 V WS G V+A ++DN++ LW SG L + ++I+S++W +K G+ Sbjct: 192 VSWSPDGEVIATGSMDNTIRLWDPKSGQCLGD-ALRGHSKWITSLSWEPIHLVKPGSKPR 250 Query: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY-ILSSGSRSGHIHHHDVRVAE 299 LA + +++WD + M+ H+ V + W +L SGS + D+ Sbjct: 251 LASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQGLLYSGSHDRTVRVWDINSQG 310 Query: 300 HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG--------------- 344 + L H+ V L + D L G D+ PS P E Sbjct: 311 RCINILKSHAHWVNHLSLSTD-YALRIGAFDH-TGKKPSTPEEAQKKALENYEKICKKNG 368 Query: 345 -----------------WVPLQT------FTQHQGAVKAVAWCPWQSNVLATGGGTSDRH 381 W PL++ T HQ V VA+ P +++ + D Sbjct: 369 NSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVS---ASFDNS 425 Query: 382 IRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK 440 I++W+ G +S H + V + WS + L+S L +W T +L Sbjct: 426 IKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCS--KDTTLKVWDVRTRKLSVDLP 483 Query: 441 GHTSRVLSLTMSPDGATVASAAADETLRLW 470 GH V ++ S DG V S D+ +RLW Sbjct: 484 GHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 69/293 (23%), Positives = 125/293 (42%), Gaps = 33/293 (11%) Query: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEY--ISSVAWIKEGNYLAVGTSSAEV 250 +S ++ A DN+ +W + + L+ G Y + V+W +G +A G+ + Sbjct: 155 TSSRMVTGAGDNTARIWDCDTQTPMHTLK----GHYNWVLCVSWSPDGEVIATGSMDNTI 210 Query: 251 QLWDVQQQKRLRN-MTSHSARVGSLSWNSY---------ILSSGSRSGHIHHHDV--RVA 298 +LWD + + L + + HS + SLSW L+S S+ G I D RV Sbjct: 211 RLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVC 270 Query: 299 EHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAV 358 ++ T+SGH+ V ++W G L SG +D V VW +G + + H V Sbjct: 271 QY---TMSGHTNSVSCVKWGGQGL-LYSGSHDRTVRVW-DINSQGRCINI--LKSHAHWV 323 Query: 359 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGH 418 ++ S A G D + + A A++ + ++C + + + Sbjct: 324 NHLS----LSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASD 379 Query: 419 GFAQNQLVIWK-YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 + + +W + +A + GH V + SPDG + SA+ D +++LW Sbjct: 380 DYT---MFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLW 429 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 28/79 (35%), Positives = 43/79 (54%), Gaps = 4/79 (5%) Query: 394 SAVDAH-SQVCSILWSPHYK-ELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTM 451 SA+ H S + ++PH +++G G N IW T + LKGH + VL ++ Sbjct: 137 SAIAGHGSTILCSAFAPHTSSRMVTGAG--DNTARIWDCDTQTPMHTLKGHYNWVLCVSW 194 Query: 452 SPDGATVASAAADETLRLW 470 SPDG +A+ + D T+RLW Sbjct: 195 SPDGEVIATGSMDNTIRLW 213 >6Q8F-A nrPDB Length = 514 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 48/170 (28%), Positives = 82/170 (48%), Gaps = 11/170 (6%) Query: 307 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPG----EGGWVPLQTFTQHQGAVKAVA 362 G V R++PDG++L +G D + VW G + + F AV + Sbjct: 213 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 272 Query: 363 WCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVD-AHSQ-VCSILWSPHYKELISGHGF 420 + + +LATG D I++W + SG CL + AHS+ V + +S +++S F Sbjct: 273 F-SRDTEMLATGA--QDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSA-SF 328 Query: 421 AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 Q + I + + E +GH+S V T + DG + SA++D T+++W Sbjct: 329 DQT-IRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIW 377 Score = 33.9 bits (76), Expect = 0.18, Method: Compositional matrix adjust. Identities = 40/205 (19%), Positives = 88/205 (42%), Gaps = 23/205 (11%) Query: 194 SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW 253 S +L+ + D ++ + SG L+ + +++ + ++G+Y+ +S V++W Sbjct: 320 SSQILSASFDQTIRIHGLKSGKTLK--EFRGHSSFVNEATFTQDGHYIISASSDGTVKIW 377 Query: 254 DVQQQKRLRNMTSHSARVGS-LSWNSYIL--------SSGSRSGHIHHHDVR---VAEHH 301 +++ + S + G+ ++ NS IL +RS + +++ V Sbjct: 378 NMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFS 437 Query: 302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 361 G C L +P G + G D ++ + + G+ +T T H+ V + Sbjct: 438 SGKREGGDFVCCAL--SPRGEWIYCVGEDFVLYCFSTVTGKLE----RTLTVHEKDVIGI 491 Query: 362 AWCPWQSNVLATGGGTSDRHIRIWN 386 A P Q N++AT + D +++W Sbjct: 492 AHHPHQ-NLIAT--YSEDGLLKLWK 513 >5Z56-q nrPDB Length = 504 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 48/202 (23%), Positives = 94/202 (46%), Gaps = 8/202 (3%) Query: 296 RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQ 355 + +E +ATL GH+++V + + P + S D + +W S P +Q H+ Sbjct: 251 KSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW-SVPNASC---VQVVRAHE 306 Query: 356 GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKE-L 414 AV ++ +L++ + D++ ++ +G L+ V + CS+ + + + L Sbjct: 307 SAVTGLSLHATGDYLLSS---SDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGL 363 Query: 415 ISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474 I G G +Q+ IW VA GH+ + S+ S +G +A+AA D +++LW + Sbjct: 364 IFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRK 423 Query: 475 LDPARRREREKASAAKSSLIHQ 496 L + + + KS + Q Sbjct: 424 LKNFKTLQLDNNFEVKSLIFDQ 445 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 42/198 (21%), Positives = 93/198 (46%), Gaps = 12/198 (6%) Query: 193 SSGNVLAVALDNSVYLWS-ASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQ 251 ++G+ L + D+ + +S +G +L + E G ++ + +G GT ++++ Sbjct: 316 ATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIK 375 Query: 252 LWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHS 309 +WD++++ + N HS + S+++ N Y L++ + + D+R ++ ++ Sbjct: 376 IWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNN 435 Query: 310 QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 369 EV L + G +LA GG D + + W + FT+H G VA+ Sbjct: 436 FEVKSLIFDQSGTYLALGGTDVQIYICKQ------WTEILHFTEHSGLTTGVAFGHHAKF 489 Query: 370 VLATGGGTSDRHIRIWNV 387 + +TG DR ++ +++ Sbjct: 490 IASTG---MDRSLKFYSL 504 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 19/52 (36%), Positives = 29/52 (55%) Query: 419 GFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 G A +V++ + +A LKGHT +V S+ P V SA+ D T+R+W Sbjct: 240 GGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291 >4LG8-A nrPDB Length = 354 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 48/202 (23%), Positives = 94/202 (46%), Gaps = 8/202 (3%) Query: 296 RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQ 355 + +E +ATL GH+++V + + P + S D + +W S P +Q H+ Sbjct: 101 KSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW-SVPNAS---CVQVVRAHE 156 Query: 356 GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKE-L 414 AV ++ +L++ + D++ ++ +G L+ V + CS+ + + + L Sbjct: 157 SAVTGLSLHATGDYLLSS---SDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGL 213 Query: 415 ISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474 I G G +Q+ IW VA GH+ + S+ S +G +A+AA D +++LW + Sbjct: 214 IFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRK 273 Query: 475 LDPARRREREKASAAKSSLIHQ 496 L + + + KS + Q Sbjct: 274 LKNFKTLQLDNNFEVKSLIFDQ 295 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 42/198 (21%), Positives = 93/198 (46%), Gaps = 12/198 (6%) Query: 193 SSGNVLAVALDNSVYLWS-ASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQ 251 ++G+ L + D+ + +S +G +L + E G ++ + +G GT ++++ Sbjct: 166 ATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIK 225 Query: 252 LWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHS 309 +WD++++ + N HS + S+++ N Y L++ + + D+R ++ ++ Sbjct: 226 IWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNN 285 Query: 310 QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 369 EV L + G +LA GG D + + W + FT+H G VA+ Sbjct: 286 FEVKSLIFDQSGTYLALGGTDVQIYICKQ------WTEILHFTEHSGLTTGVAFGHHAKF 339 Query: 370 VLATGGGTSDRHIRIWNV 387 + +TG DR ++ +++ Sbjct: 340 IASTG---MDRSLKFYSL 354 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 19/52 (36%), Positives = 29/52 (55%) Query: 419 GFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 G A +V++ + +A LKGHT +V S+ P V SA+ D T+R+W Sbjct: 90 GGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 141 >4V6W-Ag nrPDB Length = 318 Score = 65.1 bits (157), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 65/257 (25%), Positives = 109/257 (42%), Gaps = 23/257 (8%) Query: 228 YISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGS 285 +IS V +GNY G+ ++LWD+ K R H+ V S+++ ++ + SGS Sbjct: 66 FISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGS 125 Query: 286 RSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRH--LASGGNDNLVNVWPSAPGEG 343 R I + GH+ V +R++P+ + + S G D V VW A + Sbjct: 126 RDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCK- 184 Query: 344 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVC 403 H G + V P L T GG D +W++ G L ++ + + Sbjct: 185 ---LKNNHHGHNGYLNTVTVSP--DGSLCTSGG-KDSKALLWDLNDGKNLYTLEHNDIIN 238 Query: 404 SILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL---------KGHTSRVLSLTMSPD 454 ++ +SP+ L +G + + IW V EL K + LSL S D Sbjct: 239 ALCFSPNRYWLCVAYGPS---IKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTD 295 Query: 455 GATVASAAADETLRLWR 471 G T+ + +D T+R+W+ Sbjct: 296 GQTLFAGYSDNTIRVWQ 312 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 43/170 (25%), Positives = 75/170 (44%), Gaps = 13/170 (7%) Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 L GHS + + + DG + SG D + +W A G+ + F H V +VA+ Sbjct: 60 LYGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGK----TTRRFEGHTKDVLSVAFS 115 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAV--DAHSQ-VCSILWSP-HYKELISGHGF 420 +++ G+ D+ I++WN + C + D H+ V + +SP H +I G+ Sbjct: 116 ADNRQIVS---GSRDKTIKLWNTLA-ECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGW 171 Query: 421 AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 + + +W GH + ++T+SPDG+ S D LW Sbjct: 172 DRT-VKVWNLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLW 220 >5UZ7-B nrPDB Length = 351 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 63/285 (22%), Positives = 128/285 (44%), Gaps = 26/285 (9%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256 +++ + D + +W + + + + + + ++ + A+ GNY+A G +++++ Sbjct: 81 LVSASQDGKLIIWDSYTTNKVHAIPLRSS--WVMTCAYAPSGNYVACGGLDNICSIYNLK 138 Query: 257 QQK---RL-RNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHS 309 ++ R+ R + H+ + + N + SSG + + D+ + H+ Sbjct: 139 TREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW--DIETGQQTTTFTG-HT 195 Query: 310 QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 369 +V L APD R SG D +W G + QTFT H+ + A+ + P N Sbjct: 196 GDVMSLSLAPDTRLFVSGACDASAKLWDVREG----MCRQTFTGHESDINAICFFP-NGN 250 Query: 370 VLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVC---SILWSPHYKELISGHG-FAQNQL 425 ATG + D R++++ + L + +C S+ +S + L++G+ F N Sbjct: 251 AFATG--SDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCN-- 306 Query: 426 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 +W + L GH +RV L ++ DG VA+ + D L++W Sbjct: 307 -VWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 350 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 47/177 (26%), Positives = 73/177 (41%), Gaps = 25/177 (14%) Query: 304 TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS-APGEGGWVPLQTFTQHQGAVKAVA 362 TL GH ++ + W D R L S D + +W S + +PL++ V A Sbjct: 61 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRS-----SWVMTCA 115 Query: 363 WCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQ 422 + P N +A GG + N+CS L + + +V L + H L Sbjct: 116 YAP-SGNYVACGG--------LDNICSIYNLKTREGNVRVSREL-AGHTGYLSCCRFLDD 165 Query: 423 NQLV---------IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 NQ+V +W T + GHT V+SL+++PD S A D + +LW Sbjct: 166 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW 222 >5OPT-p nrPDB Length = 318 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 50/169 (29%), Positives = 80/169 (47%), Gaps = 11/169 (6%) Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 L GHS V + + +G S D+ + +W G V F H V +V + Sbjct: 63 LEGHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTG----VCQHKFLGHTKDVLSVTFS 118 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVD--AHSQ-VCSILWSPHYKELISGHGFA 421 P +++ G D +R+WNV G CL + AH+ V + +SP + + G Sbjct: 119 PDNRQIVSGG---RDNALRVWNV-KGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGW 174 Query: 422 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 N + +W + + +LKGHT+ + S+T+SPDG+ AS+ D RLW Sbjct: 175 DNLVKVWDIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLW 223 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 60/265 (22%), Positives = 111/265 (41%), Gaps = 21/265 (7%) Query: 221 QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NS 278 ++E ++S VA G++ + ++LW++Q H+ V S+++ ++ Sbjct: 62 RLEGHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDN 121 Query: 279 YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP--DGRHLASGGNDNLVNVW 336 + SG R + +V+ H H+ V +R++P + + SGG DNLV VW Sbjct: 122 RQIVSGGRDNALRVWNVKGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVW 181 Query: 337 PSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV 396 A G L H + +V P ++ A+ D R+W++ G LS + Sbjct: 182 DIASGR----LLTDLKGHTNYITSVTVSP-DGSLCASS--DKDGVARLWDLTKGEALSEM 234 Query: 397 DAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL-------KGHTSRVLSL 449 A + + I +SP+ + + + + I+ + EL T +S+ Sbjct: 235 AAGAPINQICFSPNRYWMCAA---TEKGIRIFDLENKDVIVELAPEAQQKSKKTPECMSI 291 Query: 450 TMSPDGATVASAAADETLRLWRCFE 474 S DG T+ S D +R+W E Sbjct: 292 AWSADGNTLYSGYTDNVIRVWSVSE 316 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 38/141 (26%), Positives = 63/141 (44%), Gaps = 10/141 (7%) Query: 203 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLR 262 DN V +W +SG +L L+ YI+SV +G+ A +LWD+ + + L Sbjct: 175 DNLVKVWDIASGRLLTDLKGHT--NYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALS 232 Query: 263 NMTSHSARVGSLSW--NSYILSSGSRSG----HIHHHDVRVA-EHHVATLSGHSQEVCGL 315 M + A + + + N Y + + + G + + DV V S + E + Sbjct: 233 EMAA-GAPINQICFSPNRYWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKKTPECMSI 291 Query: 316 RWAPDGRHLASGGNDNLVNVW 336 W+ DG L SG DN++ VW Sbjct: 292 AWSADGNTLYSGYTDNVIRVW 312 >5WYK-BB nrPDB Length = 943 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 74/306 (24%), Positives = 136/306 (44%), Gaps = 41/306 (13%) Query: 190 VDWSSGN-VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSA 248 +D S N +LA A + S+ +W+ + ++ + Y + ++ G + +GT + Sbjct: 397 IDISDDNKLLATASNGSLKIWNIKTHKCIRTFECG----YALTCKFLPGGLLVILGTRNG 452 Query: 249 EVQLWDVQQQKRLRNM-TSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAE------ 299 E+QL+D+ L + +H A + SL S L +GS + D +V Sbjct: 453 ELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGT 512 Query: 300 ----------HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQ 349 HH TL +C +R +PD R+LA DN V V+ + Sbjct: 513 KNKFLPVLKLHHDTTLELTDDILC-VRVSPDDRYLAISLLDNTVKVFFLDSMK----FYL 567 Query: 350 TFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSP 409 + H+ V ++ + S ++ T ++D++I+IW + G C ++ AH SI+ Sbjct: 568 SLYGHKLPVLSID-ISFDSKMIITS--SADKNIKIWGLDFGDCHKSLFAHQD--SIM--- 619 Query: 410 HYKELISGHGF---AQNQLV-IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADE 465 + K L H F +++ +V W + +L H S V +L ++ DG V S++ D Sbjct: 620 NVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWALAVATDGGFVVSSSHDH 679 Query: 466 TLRLWR 471 ++R+W Sbjct: 680 SIRIWE 685 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 48/205 (23%), Positives = 89/205 (43%), Gaps = 24/205 (11%) Query: 195 GNVLAVALDNSVYLWSASSGDILQLLQMEQP-------GEYISSVAWI---KEGNYLAVG 244 G ++ AL++ V +W +GD++ L P G + ++ K+ + LAVG Sbjct: 39 GQLITSALED-VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAVG 97 Query: 245 TSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHV 302 + +++WD+ + L N H A + L ++ L SGS+ +I D+ V E + Sbjct: 98 YADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDL-VGEVGL 156 Query: 303 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 L H + G W L S D ++ +W + ++T H G +A Sbjct: 157 YKLRSHKDSITGF-WCQGEDWLISTSKDGMIKLWDLKTHQ----CIETHIAHTGECWGLA 211 Query: 363 WCPWQSNVLATGGGTSDRHIRIWNV 387 + ++L T G +D ++IW + Sbjct: 212 ---VKDDLLITTG--TDSQVKIWKL 231 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 39/213 (18%), Positives = 85/213 (39%), Gaps = 32/213 (15%) Query: 154 QKATPGSSRKTCRY---------IPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAV---- 200 ++ GS+ KT ++ +P ++ L ++ +D L L D ++L V Sbjct: 486 KRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTD----DILCVRVSP 541 Query: 201 --------ALDNSVYLWSASSGDI-LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQ 251 LDN+V ++ S L L + P + S+ + + ++ ++ Sbjct: 542 DDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKLP---VLSIDISFDSKMIITSSADKNIK 598 Query: 252 LWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHS 309 +W + +++ +H + ++ + S+ S S+ + + D E + L H Sbjct: 599 IWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFEC-IQKLYAHQ 657 Query: 310 QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE 342 EV L A DG + S +D+ + +W + Sbjct: 658 SEVWALAVATDGGFVVSSSHDHSIRIWEETEDQ 690 >5WLC-LO nrPDB Length = 923 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 52/237 (21%), Positives = 103/237 (43%), Gaps = 12/237 (5%) Query: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRV 297 LAVG +S E +L+D+ ++ ++ V ++S N ++ S+ G + ++ + Sbjct: 275 LAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQ- 333 Query: 298 AEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGA 357 +E ++ GH L ++PDG + + D + VW G L TF +H + Sbjct: 334 SESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSG----FCLATFEEHTSS 389 Query: 358 VKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV-CSILWSPHYKELIS 416 V AV + + ++ + D +R W++ ++ + L E++ Sbjct: 390 VTAVQFAKRGQVMFSS---SLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVC 446 Query: 417 GHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 + +W T + L GH V L+ S + + +ASA+ D+T+R+W F Sbjct: 447 AGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIF 503 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 57/280 (20%), Positives = 108/280 (38%), Gaps = 40/280 (14%) Query: 227 EYISSVAWIKEGNYLAVGTSSAEVQLW---DVQQQKRLRNMTSHSARVG------SLSWN 277 E S+V + +G A+ S +Q+W DV + ++ H G SL+W+ Sbjct: 97 EKCSAVKFSPDGRLFALA-SGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWS 155 Query: 278 S---YILS-SGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLV 333 +IL+ S S I D T +GH V G ++ D + + D V Sbjct: 156 QDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAV 215 Query: 334 NVWPSAP---------------------GEGGW--VPLQTFTQHQGAVKAVAWCPWQSNV 370 VW + W F +Q VK V + P + + Sbjct: 216 FVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHP-ATRL 274 Query: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKY 430 LA G + + R++++ + + + + E ++ QL+++++ Sbjct: 275 LAVGFTSGE--FRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEW 332 Query: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 + + + + +GH SL SPDG+ V +A+ D +++W Sbjct: 333 QSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVW 372 >5GAN-H nrPDB Length = 465 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 66/288 (22%), Positives = 113/288 (39%), Gaps = 54/288 (18%) Query: 190 VDW---SSGNVLAVALDNSV--YLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVG 244 +DW S+ +++ A D + + +S G + L + IS V + G ++ Sbjct: 224 IDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSA 283 Query: 245 TSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHV 302 + +LWD + L H V SLS+ + ++ SG D+R V Sbjct: 284 SHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSK-V 342 Query: 303 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 TL+GHS+ + + W+P+G +A+GG D ++NVW + G L H+ V V Sbjct: 343 MTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEG--QLNQILAHRNIVTQVR 400 Query: 363 WCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQ 422 + GG L S Y LI+ Sbjct: 401 FSK-------EDGGKK---------------------------LVSCGYDNLIN------ 420 Query: 423 NQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 ++ T K+ L GHT +++SL +S + + S D +++LW Sbjct: 421 ----VYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLW 464 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 44/208 (21%), Positives = 87/208 (41%), Gaps = 5/208 (2%) Query: 273 SLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDN 331 SLS + ++++GS +G + + + + L H ++ + W PD + + S D Sbjct: 182 SLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDG 241 Query: 332 LVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGA 391 L+ + + EGG L H+ + V + P + G + D R+W+ + Sbjct: 242 LIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFI---GSASHDMTWRLWDASTHQ 298 Query: 392 CLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTM 451 L + H + L L+ G + +W + +KV L GH+ + ++ Sbjct: 299 ELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSM-LWDIRSGSKVMTLAGHSKPIYTVAW 357 Query: 452 SPDGATVASAAADETLRLWRCFELDPAR 479 SP+G VA+ D + +W + D + Sbjct: 358 SPNGYQVATGGGDGIINVWDIRKRDEGQ 385 >6HQA-B nrPDB Length = 722 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 56/207 (27%), Positives = 85/207 (41%), Gaps = 47/207 (22%) Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP--------SAPGEGGWV---------- 346 L GHS V G+ ++PD R+L S D V +W S G V Sbjct: 449 LVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPMGH 508 Query: 347 --------------------PLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWN 386 PL+ F H V V + P S L T G+SD+ R+W+ Sbjct: 509 YFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHP-NSTYLFT--GSSDKTARMWD 565 Query: 387 VCSGACLSAVDAHSQVCSIL-WSPHYKELISGHGFAQNQLV-IWKYPTMAKVAELKGH-T 443 + G C+ HS + L SP + L S ++ +V +W T ++ ++GH Sbjct: 566 IARGECVRVFMGHSGAINCLAVSPDGRWLASA---GEDSVVCLWDISTGRRIKAMRGHGR 622 Query: 444 SRVLSLTMSPDGATVASAAADETLRLW 470 S + SL S +G + S AD ++R+W Sbjct: 623 SSIYSLAFSREGTVLVSTGADNSVRVW 649 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 52/203 (25%), Positives = 92/203 (45%), Gaps = 15/203 (7%) Query: 190 VDWSSGN--VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247 VD+S N +++ + D +V LWS + L + + + V + G+Y A + Sbjct: 459 VDFSPDNRYLISCSEDKTVRLWSLDTYTCL--VSYKGHSSSVWDVKFSPMGHYFATASHD 516 Query: 248 AEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATL 305 +LW LR H V + + NS L +GS D+ E V Sbjct: 517 QTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGEC-VRVF 575 Query: 306 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQH-QGAVKAVAWC 364 GHS + L +PDGR LAS G D++V +W + G ++ H + ++ ++A+ Sbjct: 576 MGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRR----IKAMRGHGRSSIYSLAFS 631 Query: 365 PWQSNVLATGGGTSDRHIRIWNV 387 + +++TG +D +R+W+V Sbjct: 632 REGTVLVSTG---ADNSVRVWDV 651 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 41/193 (21%), Positives = 81/193 (41%), Gaps = 39/193 (20%) Query: 304 TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ---------- 353 T + ++ L++ D +ASG D+ + +W S G PL++ + Sbjct: 385 TFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLW-SIDGS----PLRSLLKNDPYNQQNND 439 Query: 354 ------------HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ 401 H GAV V + P +++ + D+ +R+W++ + CL + HS Sbjct: 440 GVAVKGSRRLVGHSGAVYGVDFSPDNRYLISC---SEDKTVRLWSLDTYTCLVSYKGHS- 495 Query: 402 VCSILWSPHYKELISGHGFA---QNQLV-IWKYPTMAKVAELKGHTSRVLSLTMSPDGAT 457 S +W + + GH FA +Q +W + + GH + V + P+ Sbjct: 496 --SSVWDVKFSPM--GHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTY 551 Query: 458 VASAAADETLRLW 470 + + ++D+T R+W Sbjct: 552 LFTGSSDKTARMW 564 Score = 28.1 bits (61), Expect = 9.8, Method: Compositional matrix adjust. Identities = 16/55 (29%), Positives = 30/55 (54%), Gaps = 1/55 (1%) Query: 203 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQ 257 D+ V LW S+G ++ ++ I S+A+ +EG L + V++WDV++ Sbjct: 600 DSVVCLWDISTGRRIKAMRGHGRSS-IYSLAFSREGTVLVSTGADNSVRVWDVKK 653 >5I2T-A nrPDB Length = 742 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 52/237 (21%), Positives = 103/237 (43%), Gaps = 12/237 (5%) Query: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRV 297 LAVG +S E +L+D+ ++ ++ V ++S N ++ S+ G + ++ + Sbjct: 300 LAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQ- 358 Query: 298 AEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGA 357 +E ++ GH L ++PDG + + D + VW G L TF +H + Sbjct: 359 SESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSG----FCLATFEEHTSS 414 Query: 358 VKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV-CSILWSPHYKELIS 416 V AV + + ++ + D +R W++ ++ + L E++ Sbjct: 415 VTAVQFAKRGQVMFSS---SLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVC 471 Query: 417 GHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 + +W T + L GH V L+ S + + +ASA+ D+T+R+W F Sbjct: 472 AGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIF 528 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 57/280 (20%), Positives = 108/280 (38%), Gaps = 40/280 (14%) Query: 227 EYISSVAWIKEGNYLAVGTSSAEVQLW---DVQQQKRLRNMTSHSARVG------SLSWN 277 E S+V + +G A+ S +Q+W DV + ++ H G SL+W+ Sbjct: 122 EKCSAVKFSPDGRLFALA-SGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWS 180 Query: 278 S---YILS-SGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLV 333 +IL+ S S I D T +GH V G ++ D + + D V Sbjct: 181 QDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAV 240 Query: 334 NVWPSAP---------------------GEGGW--VPLQTFTQHQGAVKAVAWCPWQSNV 370 VW + W F +Q VK V + P + + Sbjct: 241 FVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHP-ATRL 299 Query: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKY 430 LA G + + R++++ + + + + E ++ QL+++++ Sbjct: 300 LAVGFTSGE--FRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEW 357 Query: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 + + + + +GH SL SPDG+ V +A+ D +++W Sbjct: 358 QSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVW 397 >6GMH-W nrPDB Length = 305 Score = 61.6 bits (148), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 49/167 (29%), Positives = 84/167 (50%), Gaps = 10/167 (5%) Query: 222 MEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSY 279 ++ G++I S+A+ +G YLA G + ++D+ K L + H+ + SL++ +S Sbjct: 144 LDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQ 203 Query: 280 ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSA 339 +L + S G+I +DV+ A + TLSGH+ V + + PD H S +D V VW Sbjct: 204 LLVTASDDGYIKIYDVQHA-NLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDV- 261 Query: 340 PGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWN 386 G + TF HQ V V + S +++ G D+ I I++ Sbjct: 262 ---GTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVG---DDQEIHIYD 302 Score = 61.2 bits (147), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 48/229 (20%), Positives = 110/229 (48%), Gaps = 13/229 (5%) Query: 247 SAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVAT 304 A ++LWD++ K+++++ + +L++ +S L++G+ G ++ V + + Sbjct: 85 DAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEY-S 143 Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 L + + + ++PDG++LASG D ++N++ A G+ L T H ++++ + Sbjct: 144 LDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGK----LLHTLEGHAMPIRSLTFS 199 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQN 423 P S +L T + D +I+I++V + H S V ++ + P +S + Sbjct: 200 P-DSQLLVT--ASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSS--SDK 254 Query: 424 QLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 + +W T V H +V + + +G+ + S D+ + ++ C Sbjct: 255 SVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDC 303 >5WYJ-BC nrPDB Length = 817 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 45/181 (24%), Positives = 84/181 (46%), Gaps = 14/181 (7%) Query: 294 DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ 353 DV++ + T H +++ L +P+ A+ D +W GE T Sbjct: 476 DVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELE----ATLAN 531 Query: 354 HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS---QVCSILWSPH 410 H+ + V++C + +LAT G D+ ++IW++ + + + ++ H+ Q CS + Sbjct: 532 HKRGLWDVSFCQYDK-LLATSSG--DKTVKIWSLDTFSVMKTLEGHTNAVQRCSFI--NK 586 Query: 411 YKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 K+LIS A + IW + + L GH +R+ +L+ DG + SA AD + W Sbjct: 587 QKQLISCG--ADGLIKIWDCSSGECLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFW 644 Query: 471 R 471 + Sbjct: 645 K 645 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 41/151 (27%), Positives = 70/151 (46%), Gaps = 23/151 (15%) Query: 207 YLWSASSGDILQLLQMEQPGEY-----ISSVAWIKEGN----YLAVGTSSAEVQLWDVQQ 257 YL S +L++ + + G+ ISS ++I + + LAVG + + + D++ Sbjct: 75 YLTYVSQAQLLKIFHL-KTGKVVRSMKISSPSYILDADSTSTLLAVGGTDGSIIVVDIEN 133 Query: 258 QKRLRNMTSHSARVGSLSW----NSYI--LSSGSRSGHIHHHDVRVAEHHVATLSGHSQE 311 + H + SL + NS I L+SG +G + D+ V + TL H+ Sbjct: 134 GYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDL-VKRKCLHTLQEHTSA 192 Query: 312 VCGLRW--APDGR----HLASGGNDNLVNVW 336 V GL PD +L SGG D+++N+W Sbjct: 193 VRGLDIIEVPDNDEPSLNLLSGGRDDIINLW 223 Score = 28.9 bits (63), Expect = 5.2, Method: Compositional matrix adjust. Identities = 85/387 (21%), Positives = 144/387 (37%), Gaps = 71/387 (18%) Query: 126 EEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDY 185 +E +I L P Y ++ ++L G ++ + S P ILDA Sbjct: 60 DEQEITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKI--SSPSYILDADSTST-- 115 Query: 186 YLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGN----YL 241 L V + G+++ V ++N Y+ + G G ISS+ + + N L Sbjct: 116 -LLAVGGTDGSIIVVDIENG-YITHSFKG----------HGGTISSLKFYGQLNSKIWLL 163 Query: 242 AVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--------SYILSSGSRSGHIHHH 293 A G ++ V++WD+ ++K L + H++ V L S L SG R I+ Sbjct: 164 ASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLW 223 Query: 294 DVRVAEHHVATLS---GHSQEVCGLRWAPDG-RHLASGGNDNLVNVWPSAPGEGGWVPLQ 349 D + + + E CG DG R + + G D + + S G L+ Sbjct: 224 DFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGS----VLK 279 Query: 350 TFTQHQGAVKAVAWCPWQSN-----VLATGGGTSDRHIRIWNV---------CSGACLSA 395 + + + P SN VL SD+ +++ NV S Sbjct: 280 RTNKPIEELFIIGVLPILSNSQMFLVL------SDQTLQLINVEEDLKNDEDTIQVTSSI 333 Query: 396 VDAHSQVCSILW-SPHYKELISGHGFAQNQ--LVIWKYPTMA--------KVAELKGHTS 444 H + + + P +L A N L I P ++ V +GH Sbjct: 334 AGNHGIIADMRYVGPELNKL----ALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHED 389 Query: 445 RVLSLTMSPDGATVASAAADETLRLWR 471 + SL + DG +A+A+ D T +WR Sbjct: 390 LLNSLDATEDGLWIATASKDNTAIVWR 416 >3C9C-A nrPDB Length = 432 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 50/202 (24%), Positives = 84/202 (41%), Gaps = 11/202 (5%) Query: 305 LSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWP--SAPGEGGWVPLQT-FTQHQGAVKA 360 L GH +E GL W P+ +L S +D+ + +W + P E + + FT H V+ Sbjct: 179 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 238 Query: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS---AVDAHSQVCSILWSPHYKELISG 417 VAW ++ G D+ + IW+ + VDAH+ + L Y E I Sbjct: 239 VAWHLLHESLF--GSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILA 296 Query: 418 HGFAQNQLVIWKYPTMA-KVAELKGHTSRVLSLTMSPDGATV-ASAAADETLRLWRCFEL 475 G A + +W + K+ + H + + SP T+ AS+ D L +W ++ Sbjct: 297 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKI 356 Query: 476 DPARRREREKASAAKSSLIHQG 497 + E + + IH G Sbjct: 357 GEEQSTEDAEDGPPELLFIHGG 378 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 32/117 (27%), Positives = 57/117 (48%), Gaps = 10/117 (8%) Query: 229 ISSVAW--IKEGNYLAVGTSSAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWNSY---I 280 + VAW + E + +V ++ +WD + K + +H+A V LS+N Y I Sbjct: 236 VEDVAWHLLHESLFGSVA-DDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI 294 Query: 281 LSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW 336 L++GS + D+R + + + H E+ ++W+P LAS G D ++VW Sbjct: 295 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW 351 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 55/250 (22%), Positives = 99/250 (39%), Gaps = 50/250 (20%) Query: 240 YLAVGTSSAEVQLWDVQ---QQKRLRN----MTSHSARVGSLSWN---SYILSSGSRSGH 289 YL + + LWD+ ++ R+ + T H+A V ++W+ + S + Sbjct: 198 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 257 Query: 290 IHHHDVRV--AEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWV 346 + D R T+ H+ EV L + P LA+G D V +W + + Sbjct: 258 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK---L 314 Query: 347 PLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAVDAHSQVCSI 405 L +F H+ + V W P +LA+ G +DR + +W++ G S DA Sbjct: 315 KLHSFESHKDEIFQVQWSPHNETILASSG--TDRRLHVWDLSKIGEEQSTEDAED----- 367 Query: 406 LWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVASAAAD 464 P EL+ HG GHT+++ + +P+ + S + D Sbjct: 368 --GP--PELLFIHG---------------------GHTAKISDFSWNPNEPWIICSVSED 402 Query: 465 ETLRLWRCFE 474 +++W+ E Sbjct: 403 NIMQVWQMAE 412 >6ID0-T nrPDB Length = 514 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 56/244 (22%), Positives = 108/244 (44%), Gaps = 24/244 (9%) Query: 235 IKEGN-YLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSL---SWNSYILSSGSRSGHI 290 ++ GN + G++ +++WD+ K ++T H + V + + + Y+ S G + Sbjct: 212 VEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCG-EDKQV 270 Query: 291 HHHDV---RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVP 347 D+ +V H+ GH V GL P L + D+ +W Sbjct: 271 KCWDLEYNKVIRHY----HGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKAS---- 322 Query: 348 LQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSIL 406 + T + H AV V + ++ G+ D IR+W++ +G + H + V +++ Sbjct: 323 VHTLSGHTNAVATVRCQAAEPQIIT---GSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVV 379 Query: 407 WSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADET 466 P + SG + + + WK+P + + L GH + + +LT++ DG V S A + T Sbjct: 380 LHPRHYTFASG---SPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLV-SGADNGT 435 Query: 467 LRLW 470 + LW Sbjct: 436 MHLW 439 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 37/167 (22%), Positives = 66/167 (39%), Gaps = 10/167 (5%) Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 +SGH V + P + +G D + +W A G+ + T H V+ V Sbjct: 200 ISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL----SLTGHISTVRGVIVS 255 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQN 423 + + G D+ ++ W++ + H S V + P L++ + Sbjct: 256 TRSPYLFSCG---EDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTA 312 Query: 424 QLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 + IW T A V L GHT+ V ++ + + + D T+RLW Sbjct: 313 R--IWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLW 357 >6HHQ-h nrPDB Length = 319 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 48/176 (27%), Positives = 78/176 (44%), Gaps = 13/176 (7%) Query: 302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 361 V + GHS V DG + S D + +W A GE Q F H+ V +V Sbjct: 58 VRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGE----TYQRFVGHKSDVMSV 113 Query: 362 AWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYK---ELISG 417 S +++ G+ D+ I++W + G CL+ + H+ V + P+ K + ++ Sbjct: 114 DIDKKASMIIS---GSRDKTIKVWTI-KGQCLATLLGHNDWVSQVRVVPNEKADDDSVTI 169 Query: 418 HGFAQNQLV-IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 +++V W A+ GH S + +LT SPDG +ASA D + LW Sbjct: 170 ISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNL 225 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 64/273 (23%), Positives = 106/273 (38%), Gaps = 38/273 (13%) Query: 216 ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS 275 I+Q + G Y S +W K ++LWDV + + H + V S+ Sbjct: 67 IVQDCTLTADGAYALSASWDKT------------LRLWDVATGETYQRFVGHKSDVMSVD 114 Query: 276 WN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP------DGRHLASG 327 + + ++ SGSR I ++ +ATL GH+ V +R P D + S Sbjct: 115 IDKKASMIISGSRDKTIKVWTIK--GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISA 172 Query: 328 GNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 387 GND +V W + F H + + P ++A+ G D I +WN+ Sbjct: 173 GNDKMVKAWNLNQFQ----IEADFIGHNSNINTLTASP-DGTLIASAG--KDGEIMLWNL 225 Query: 388 CSGACLSAVDAHSQVCSILWSPHYKEL-------ISGHGFAQNQLVIWKYPTMAKVAELK 440 + + + A +V S+ +SP+ L I LV P A + K Sbjct: 226 AAKKAMYTLSAQDEVFSLAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYS--K 283 Query: 441 GHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 +SL S DG T+ + D +R+W+ Sbjct: 284 AAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVM 316 Score = 36.6 bits (83), Expect = 0.025, Method: Compositional matrix adjust. Identities = 35/151 (23%), Positives = 73/151 (48%), Gaps = 18/151 (11%) Query: 203 DNSVYLWSASSGDILQ---LLQMEQPGEYISSVAWIK------EGNYLAVGTSSAEVQLW 253 D+SV + SA + +++ L Q + ++I + I +G +A E+ LW Sbjct: 164 DDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLW 223 Query: 254 DVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSG-HIHHHDVR-VAEHHVATLSGHS 309 ++ +K + +++ V SL++ N Y L++ + +G + D + + + +G+S Sbjct: 224 NLAAKKAMYTLSAQD-EVFSLAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYS 282 Query: 310 Q----EVCGLRWAPDGRHLASGGNDNLVNVW 336 + L W+ DG+ L +G DN++ VW Sbjct: 283 KAAEPHAVSLAWSADGQTLFAGYTDNVIRVW 313 >2YNP-A nrPDB Length = 604 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 55/228 (24%), Positives = 90/228 (39%), Gaps = 10/228 (4%) Query: 247 SAEVQLWDVQQQKRLRNM--TSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVAT 304 S V+LW+ + Q +R++ T R G + GS I + E V Sbjct: 34 SGRVELWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEK-VVD 92 Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 H + + P ++ SG +D V +W E W QTF H+ V VA+ Sbjct: 93 FEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWN---WENNWALEQTFEGHEHFVMCVAFN 149 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ--VCSILWSPHYKELISGHGFAQ 422 P + A+ G DR +++W++ + + V + + P + Sbjct: 150 PKDPSTFAS--GCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDD 207 Query: 423 NQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 + IW Y T + VA L+GH S V P + S + D TL++W Sbjct: 208 LTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIW 255 >6N9G-C nrPDB Length = 353 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 68/297 (22%), Positives = 128/297 (43%), Gaps = 29/297 (9%) Query: 190 VDWSSGN--VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247 +DW +++ + D V +W + + + + M P ++ + A+ G +A G Sbjct: 69 MDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTM--PCTWVMACAYAPSGCAIACGGLD 126 Query: 248 AEVQLWDVQQQK------RLRNMTSHSARVGSLSW-NSYI-LSSGSRSGHIHHHDVRVAE 299 + ++ + K + +++ H+ + + S+ NS + + + S G DV + Sbjct: 127 NKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQ 186 Query: 300 HHVATLSGHSQEVCGLRWAPD--GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGA 357 + + GH +V L AP G SGG D VW G+ +Q F H+ Sbjct: 187 L-LQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQ----CVQAFETHESD 241 Query: 358 VKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISG 417 V +V + P A G+ D R++++ + V +S+ I + +SG Sbjct: 242 VNSVRYYPSGD---AFASGSDDATCRLYDLRAD---REVAIYSKESIIFGASSVDFSLSG 295 Query: 418 H----GFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 G+ + +W ++V+ L GH +RV +L +SPDG S + D TLR+W Sbjct: 296 RLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 56/234 (23%), Positives = 85/234 (36%), Gaps = 51/234 (21%) Query: 304 TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS------------------------- 338 TL GH +V + W D R + S D V VW S Sbjct: 58 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 117 Query: 339 -APGEGGW------VPLQTFTQHQGAV---KAVAW-------CPWQSNVLATGGGTSDRH 381 A GG PL TF +++ K+VA C + ++ + + D Sbjct: 118 CAIACGGLDNKCSVYPL-TFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 176 Query: 382 IRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK 440 +W+V SG L + H + V + +P G + ++W + V + Sbjct: 177 CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFE 236 Query: 441 GHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLI 494 H S V S+ P G AS + D T RL+ R +RE A +K S+I Sbjct: 237 THESDVNSVRYYPSGDAFASGSDDATCRLYD-------LRADREVAIYSKESII 283 >3MKQ-A nrPDB Length = 814 Score = 58.2 bits (139), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 56/232 (24%), Positives = 91/232 (39%), Gaps = 18/232 (7%) Query: 247 SAEVQLWDVQQQKRLRNM--TSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVAT 304 S V++W+ + Q +R++ T R G + GS I + E V Sbjct: 34 SGRVEIWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEK-VVD 92 Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 H + + P ++ SG +D V +W E W QTF H+ V VA+ Sbjct: 93 FEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWN---WENNWALEQTFEGHEHFVMCVAFN 149 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSG----ACLSAVDAHSQVCSILWSPHYKELISGHGF 420 P + A+ G DR +++W++ + + P +I+ Sbjct: 150 PKDPSTFAS--GCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMIT---- 203 Query: 421 AQNQLV--IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 A + L IW Y T + VA L+GH S V P + S + D TL++W Sbjct: 204 ASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIW 255 >6G51-g nrPDB Length = 317 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 66/292 (22%), Positives = 121/292 (41%), Gaps = 28/292 (9%) Query: 197 VLAVALDNSVYLWSASSGDI---LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW 253 +L+ + D ++ +W + + + + ++S V +G + G+ ++LW Sbjct: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90 Query: 254 DVQQQKRLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQE 311 D+ R H+ V S++++S + SGSR I + + HS+ Sbjct: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150 Query: 312 VCGLRWAPDGRH--LASGGNDNLVNVWPSAPGEGGWVPLQT-FTQHQGAVKAVAWCPWQS 368 V +R++P+ + + S G D LV VW A L+T H G + V P Sbjct: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN-----CKLKTNHIGHTGYLNTVTVSP-DG 204 Query: 369 NVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIW 428 ++ A+GG D +W++ G L +D + ++ +SP+ L + G + IW Sbjct: 205 SLCASGG--KDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATG---PSIKIW 259 Query: 429 KYPTMAKVAELKGHTS---------RVLSLTMSPDGATVASAAADETLRLWR 471 V ELK + SL S DG T+ + D +R+W+ Sbjct: 260 DLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 Score = 36.2 bits (82), Expect = 0.032, Method: Compositional matrix adjust. Identities = 33/127 (25%), Positives = 54/127 (42%), Gaps = 10/127 (7%) Query: 350 TFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-----GACLSAVDAHSQVCS 404 T H G V +A P +++ + + D+ I +W + G A+ HS S Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSA--SRDKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67 Query: 405 -ILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAA 463 ++ S + +SG L +W T GHT VLS+ S D + S + Sbjct: 68 DVVISSDGQFALSGS--WDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 Query: 464 DETLRLW 470 D+T++LW Sbjct: 126 DKTIKLW 132 >1NR0-A nrPDB Length = 611 Score = 58.2 bits (139), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 65/290 (22%), Positives = 112/290 (38%), Gaps = 66/290 (22%) Query: 238 GNYLAVGTSSAEVQLWDVQQQKRLRNMT--SHSARVGSLSWNSY---ILSSGS---RSGH 289 G Y A G V++WD Q + T S V +SW+S I + G R GH Sbjct: 71 GYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGH 130 Query: 290 IHHHDVRVA-----------------------------EHHVATLSG-----------HS 309 + D + ++ VA G H+ Sbjct: 131 VFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHT 190 Query: 310 QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV----PLQTFTQHQGAVKAVAWCP 365 + V +R+ PDG AS G D + ++ G V L+ H G+V + W P Sbjct: 191 KFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKN-VAHSGSVFGLTWSP 249 Query: 366 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV----CSILWSPHYKELISGHGFA 421 + + + ++D+ I+IWNV + + +++ I+W+ IS +GF Sbjct: 250 DGTKIAS---ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFI 306 Query: 422 QNQLVIWKYPTMAKVAELK-GHTSRVLSLTMSPDGATVASAAADETLRLW 470 + P + + +++ GH + +L+ S DG T+ SA A+ + W Sbjct: 307 N-----FVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 45/173 (26%), Positives = 80/173 (46%), Gaps = 15/173 (8%) Query: 223 EQPGEYISS-VAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMT-SHSARVGSLSW--NS 278 E P Y SS VA + ++AVG ++V ++ + T H A + S+++ N Sbjct: 444 EVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNG 503 Query: 279 YILSSGSRSGHIHHHDV--RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 336 L + +S + + V H + + H+ +V + W+PD LA+G DN V VW Sbjct: 504 AFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVW 563 Query: 337 P-SAPGEGGWVPLQTFTQH-QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 387 + P + P+ H +V +V W ++ +++ G D +I+ WNV Sbjct: 564 NMNKPSDH---PIIIKGAHAMSSVNSVIWLN-ETTIVSAG---QDSNIKFWNV 609 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 39/166 (23%), Positives = 69/166 (41%), Gaps = 7/166 (4%) Query: 308 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQ 367 HS + + +P G + ASG V +W + + + T G VK ++W Sbjct: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTT--QTTHILKTTIPVFSGPVKDISWDSES 115 Query: 368 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVC-SILWSPHYK-ELISGHGFAQNQL 425 + A G G +R ++ +G + ++ S+ + P +ISG N + Sbjct: 116 KRIAAVGEG-RERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSD--DNTV 172 Query: 426 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 I++ P + HT V S+ +PDG+ AS D T+ L+ Sbjct: 173 AIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN 218 >6J6H-n nrPDB Length = 455 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 46/180 (25%), Positives = 87/180 (48%), Gaps = 25/180 (13%) Query: 302 VATLSGHSQEVCGLRWAPDGRHLA-SGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 360 + GH + L++ P HL SGGND+ + +W + L+ F H +KA Sbjct: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFY---HDYECLRDFQGHNKPIKA 211 Query: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS---QVCSILWSPHYKELISG 417 + + + L++ + DR ++IW+ +G + + +S V S +PH E I G Sbjct: 212 LRFTEDCQSFLSS---SFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPH--EFIVG 266 Query: 418 HGFAQNQLVIWKYPTMAKVAELKG-------HTSRVLSLTMSPDGATVASAAADETLRLW 470 + ++++ + +V+E +G H S +L+L PDG+ S++ D+T+R+W Sbjct: 267 --LSNSKILHYD----DRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 56/250 (22%), Positives = 101/250 (40%), Gaps = 22/250 (8%) Query: 102 ENSQ-TPTKKEHQKAW--ALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATP 158 E SQ + T+KE Q + AL + D E+ ++ +S + + YQ R + Sbjct: 78 ETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDV 137 Query: 159 GSSRKTCRYIPSLPDRILDAPEIRN-------DYYLNLVDWSSGNVLAVALDNSVYLWSA 211 + + LP ++ IRN L + + +L+ D+++ +W Sbjct: 138 DLREERISFRCYLPKKV-----IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF 192 Query: 212 SSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQK---RLRNMTSHS 268 D L + + I ++ + ++ + V++WD + K RL ++ S Sbjct: 193 YH-DYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRL-HLNSTP 250 Query: 269 ARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHH--VATLSGHSQEVCGLRWAPDGRHLAS 326 A V S N + G + I H+D RV+E+ V T H + L++ PDG S Sbjct: 251 ADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFIS 310 Query: 327 GGNDNLVNVW 336 D V +W Sbjct: 311 SSEDKTVRIW 320 >4BTS-AR nrPDB Length = 343 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 45/188 (23%), Positives = 77/188 (40%), Gaps = 19/188 (10%) Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 L+GH+ V L + + S D + +W G + F HQ V +VA+ Sbjct: 72 LTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTG----TTYKRFVGHQSEVYSVAFS 127 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ---VCSILWSPHYKELISGHGFA 421 P +L+ G ++R I++WN+ S+ + + V + +SP K FA Sbjct: 128 PDNRQILSAG---AEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFA 184 Query: 422 --------QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 +L +W + K H S V L++SP+G +A+ D+ L +W Sbjct: 185 PYFASVGWDGRLKVWNTNFQIRYT-FKAHESNVNHLSISPNGKYIATGGKDKKLLIWDIL 243 Query: 474 ELDPARRR 481 L +R Sbjct: 244 NLTYPQRE 251 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 33/170 (19%), Positives = 73/170 (42%), Gaps = 22/170 (12%) Query: 184 DYYLNLVDWSSGNVLAVA--LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYL 241 +++++ + S N A++ D ++ LW +G + Q Y SVA+ + + Sbjct: 76 NHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVY--SVAFSPDNRQI 133 Query: 242 AVGTSSAEVQLWDVQQQKRLRNMT--SHSARVGSLSWNSYILSSGSR------------- 286 + E++LW++ + + + +HS V + + S I+ S ++ Sbjct: 134 LSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRY-SPIMKSANKVQPFAPYFASVGW 192 Query: 287 SGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 336 G + + + T H V L +P+G+++A+GG D + +W Sbjct: 193 DGRLKVWNTNFQIRY--TFKAHESNVNHLSISPNGKYIATGGKDKKLLIW 240 >6EOJ-D nrPDB Length = 470 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 65/334 (19%), Positives = 136/334 (40%), Gaps = 17/334 (5%) Query: 152 YSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVALDNSVY-LW 209 Y+ P ++ + + +LP + + + + + W+ G L VA + + LW Sbjct: 61 YTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLW 120 Query: 210 SASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW--DVQQQKRLRNMTSH 267 +ASS L+Q ++++ + + +++ G + +++W + K + + Sbjct: 121 NASSFTFETLMQAHDSA--VTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTE 178 Query: 268 SARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASG 327 S R + S N + S + + + LSGH +V W P+ +AS Sbjct: 179 SIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE-RVLSGHHWDVKSCDWHPEMGLIASA 237 Query: 328 GNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 387 DNLV +W G + + + + V + P + N+L + D+ R++++ Sbjct: 238 SKDNLVKLWDPRSGNC----ISSILKFKHTVLKTRFQPTKGNLLM--AISKDKSCRVFDI 291 Query: 388 -CSGACLSAVDAHSQVCSILWSPHYKELISGHGF--AQNQLVIWKYPTMAKVAELKGHTS 444 S L V + ++ W P + + + + + + + + H Sbjct: 292 RYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDK 351 Query: 445 RVLSLTMSPDGATVASAAADETLRLW-RCFELDP 477 + SL+ +P G A+AA D T+R W R +DP Sbjct: 352 CITSLSYNPVGHIFATAAKDRTIRFWTRARPIDP 385 >3DM0-A nrPDB Length = 694 Score = 55.1 bits (131), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 68/302 (22%), Positives = 128/302 (42%), Gaps = 38/302 (12%) Query: 197 VLAVALDNSVYLWSASSGD-ILQLLQMEQPGE--YISSVAWIKEGNYLAVGTSSAEVQLW 253 +++ + D S+ LW + D + Q G ++ V +G + G+ E++LW Sbjct: 398 IVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQFALSGSWDGELRLW 457 Query: 254 DVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATL--SGHS 309 D+ R H+ V S+++ ++ + S SR I + + + GH Sbjct: 458 DLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTLGECKYTISEGGEGHR 517 Query: 310 QEVCGLRWAPDGRH--LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQ 367 V +R++P+ + S D V VW + + T H G V VA P Sbjct: 518 DWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCK----LRSTLAGHTGYVSTVAVSP-D 572 Query: 368 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVI 427 ++ A+GG D + +W++ G L +++A+S + ++ +SP+ L + ++ + I Sbjct: 573 GSLCASGG--KDGVVLLWDLAEGKKLYSLEANSVIHALCFSPNRYWLCAA---TEHGIKI 627 Query: 428 WKYPTMAKVAELK---------------GHTSRVL----SLTMSPDGATVASAAADETLR 468 W + + V +LK T R + SL S DG+T+ S D +R Sbjct: 628 WDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLFSGYTDGVIR 687 Query: 469 LW 470 +W Sbjct: 688 VW 689 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 45/175 (25%), Positives = 74/175 (42%), Gaps = 13/175 (7%) Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 L+GHS V + + DG+ SG D + +W A G V + F H V +VA+ Sbjct: 426 LTGHSHFVEDVVLSSDGQFALSGSWDGELRLWDLAAG----VSTRRFVGHTKDVLSVAFS 481 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-----VCSILWSPHYKELISGHG 419 +++ + DR I++WN G C + + V + +SP+ + Sbjct: 482 LDNRQIVS---ASRDRTIKLWNTL-GECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSA 537 Query: 420 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474 + +W + L GHT V ++ +SPDG+ AS D + LW E Sbjct: 538 SWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAE 592 Score = 36.6 bits (83), Expect = 0.024, Method: Compositional matrix adjust. Identities = 33/136 (24%), Positives = 55/136 (40%), Gaps = 10/136 (7%) Query: 344 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-----GACLSAVDA 398 G V T H V A+A ++++ + + D+ I +W + G + Sbjct: 371 GLVLKGTMRAHTDMVTAIATPIDNADIIVSA--SRDKSIILWKLTKDDKAYGVAQRRLTG 428 Query: 399 HSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGAT 457 HS V ++ S + +SG +L +W GHT VLS+ S D Sbjct: 429 HSHFVEDVVLSSDGQFALSGSW--DGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQ 486 Query: 458 VASAAADETLRLWRCF 473 + SA+ D T++LW Sbjct: 487 IVSASRDRTIKLWNTL 502 >4J0W-A nrPDB Length = 343 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 51/180 (28%), Positives = 77/180 (42%), Gaps = 25/180 (13%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPG---------EYISSVAWIKEGNYLAVGTSS 247 + + A D S+ WS SG L ++ + G ++ +A +G YLA G S Sbjct: 29 IFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRS 88 Query: 248 AEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVR---VAEH-H 301 + +W+ Q + L T H V L++ ++ L S S H V+ VAE+ + Sbjct: 89 KLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTS-----HDRSVKVWNVAENSY 143 Query: 302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 361 V TL GH V L + +GG D V VW P E V F HQG++ + Sbjct: 144 VETLFGHQDAVAALDALSRECCVTAGGRDGTVRVW-KIPEESQLV----FYGHQGSIDCI 198 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 41/164 (25%), Positives = 74/164 (45%), Gaps = 10/164 (6%) Query: 307 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW 366 GHS V + + DG++LASG L+ +W + + L TFT H+ AV +A+ Sbjct: 65 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQ----HLYTFTGHRDAVSGLAFRRG 120 Query: 367 QSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLV 426 + +T + DR +++WNV + + + H + L +E G + Sbjct: 121 THQLYST---SHDRSVKVWNVAENSYVETLFGHQDAVAAL-DALSRECCVTAGGRDGTVR 176 Query: 427 IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 +WK P +++ GH + + + + V S A D ++ LW Sbjct: 177 VWKIPEESQLV-FYGHQGSIDCIHLINEEHMV-SGADDGSVALW 218 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 22/40 (55%) Query: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 P A + L+GH + L ++PD + + SAA D ++ W Sbjct: 2 PEAADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKW 41 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 30/98 (30%), Positives = 47/98 (47%), Gaps = 13/98 (13%) Query: 196 NVLAVALDNSVYLWSASSGDILQLLQ----------MEQPGEYISSVAWIKEGNYLAVGT 245 ++++ A D SV LW S L L + +EQP +ISSVA + + +A G+ Sbjct: 205 HMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQP-FWISSVAALLNTDLVATGS 263 Query: 246 SSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSS 283 S+ V+LW + R ++ VG + NS SS Sbjct: 264 HSSCVRLWQCGEGFRQLDLLCDIPLVGFI--NSLKFSS 299 >5OQL-L nrPDB Length = 557 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 54/247 (21%), Positives = 103/247 (41%), Gaps = 14/247 (5%) Query: 230 SSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNM--TSHSARVGSLSWNSYILSSGSRS 287 S VA K + AV T+ V+++ +++++ L+ + A G + + +L +G + Sbjct: 62 SLVAAAKTNDLFAV-TAGPRVEIFSIRKREPLKTIGRFDSEAHCGEIRPDGRVLVAGEDT 120 Query: 288 GHIHHHDVRVAEHHVA--TLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGG 344 G + DV V T H Q V +W+P + L S +D V +W + Sbjct: 121 GRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSND-- 178 Query: 345 WVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV-CSGACLSAVDAHSQVC 403 P + FT H V+ A+ P +N G+ D +R+W+ G + + Sbjct: 179 --PTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIE 236 Query: 404 SILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAA 463 +L P L++ G N + + + + H V SL+++ G V S + Sbjct: 237 DVLPLPSGTTLLAASG---NAISVLDLVAAKPLRLITNHQKTVTSLSLASQGRRVVSGSL 293 Query: 464 DETLRLW 470 D ++++ Sbjct: 294 DGHVKVF 300 >5FVM-C nrPDB Length = 303 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 46/196 (23%), Positives = 90/196 (45%), Gaps = 23/196 (11%) Query: 287 SGHIH--HHDVRVAEHH-VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP-SAPGE 342 +GH+H +D+R + V++ GH V + + + R + S D + VW +P Sbjct: 50 AGHLHVRLYDIRSNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPS- 108 Query: 343 GGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV--DAHS 400 +Q +H V VA P Q +++ D +IRIW++ C + + + ++ Sbjct: 109 -----VQRNYKHNAPVNEVAIHPNQGELISCD---QDGNIRIWDLGENQCTNQLTPEDNT 160 Query: 401 QVCSILWSPHYKELISGHGFAQNQLVIWKYP------TMAKVAELKGHTSRVLSLTMSPD 454 + S+ + L++G+ + +W+ P T+ V + K HT + + +S D Sbjct: 161 PLQSLSVASDGSMLVAGNN--KGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSAD 218 Query: 455 GATVASAAADETLRLW 470 +A+ +AD T R+W Sbjct: 219 VKNLATCSADHTARVW 234 Score = 33.1 bits (74), Expect = 0.31, Method: Compositional matrix adjust. Identities = 46/218 (21%), Positives = 89/218 (40%), Gaps = 8/218 (3%) Query: 229 ISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSR 286 ++S+A+ +E ++ + +++WDV+ RN H+A V ++ N L S + Sbjct: 78 VTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNY-KHNAPVNEVAIHPNQGELISCDQ 136 Query: 287 SGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV 346 G+I D+ + + + L A DG L +G N VW P Sbjct: 137 DGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYVW-RMPHHTDAS 195 Query: 347 PLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACL-SAVDAHSQ-VCS 404 L+ T+ + K + ++V ++D R+WN+ L + +D H + V Sbjct: 196 TLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDNYQLETTLDGHQRWVWD 255 Query: 405 ILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGH 442 +S L++ + + + +W T V + GH Sbjct: 256 CAFSADSAYLVT--ACSDHYVRLWDLSTSEIVRQYGGH 291 >5Y88-O nrPDB Length = 451 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 61/285 (21%), Positives = 123/285 (43%), Gaps = 34/285 (11%) Query: 203 DNSVYLWSASSGDILQLLQMEQPGEYIS--SVAWIKEGNYLAVGTSSAEVQLWDVQQQKR 260 D ++ +W ++G L+ G ++ VA YL + V+ WD+++ + Sbjct: 161 DTTMKVWDLATGK----LKTTLAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQI 216 Query: 261 LRNMTSHSARVGSLSWNSYI--LSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWA 318 +R+ H + V ++S + + +++ R I D+R V TL GH + ++ Sbjct: 217 IRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMR-TRIPVITLVGHKGPINQVQCT 275 Query: 319 PDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTS 378 P + S D V +W G+ ++ T H+ +V+A A P + +V + T Sbjct: 276 PVDPQVVSSSTDATVRLWDVVAGK----TMKVLTHHKRSVRATALHPKEFSVAS--ACTD 329 Query: 379 DRHIRIWNVCSGACLSAVDAHSQVC---------SILWSPHYKELISGHGFAQNQLVIWK 429 D IR W + G+ L+ ++ +L++ ++S + + K Sbjct: 330 D--IRSWGLAEGSLLTNFESEKTGIINTLSINQDDVLFAGGDNGVLSFYDYKSGH----K 383 Query: 430 YPTMAK---VAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 Y ++A V L+G S VL T G + + AD+++++W+ Sbjct: 384 YQSLATREMVGSLEGERS-VLCSTFDKTGLRLITGEADKSIKIWK 427 Score = 37.0 bits (84), Expect = 0.020, Method: Compositional matrix adjust. Identities = 36/152 (23%), Positives = 62/152 (40%), Gaps = 10/152 (6%) Query: 320 DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSD 379 D +G ND + VW A G+ T H V+ VA + + + D Sbjct: 151 DNEWFITGSNDTTMKVWDLATGKLK----TTLAGHVMTVRDVAVSDRHPYLFSV---SED 203 Query: 380 RHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAE 438 + ++ W++ + H S V ++ P +LI+ G + + +W T V Sbjct: 204 KTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTL-DLIATAG-RDSVIKLWDMRTRIPVIT 261 Query: 439 LKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 L GH + + +P V S++ D T+RLW Sbjct: 262 LVGHKGPINQVQCTPVDPQVVSSSTDATVRLW 293 >5OQL-J nrPDB Length = 912 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 78/366 (21%), Positives = 130/366 (35%), Gaps = 71/366 (19%) Query: 166 RYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVAL--------DNSVYLWSASSGDIL 217 R I D ILD I D + + +S ++ V++ DN+ + G + Sbjct: 367 RRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDV 426 Query: 218 QLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRN----MTSHSARVGS 273 LL+ + V W G+++A G+ +LW V T H VG+ Sbjct: 427 ALLKGHEDIVMSLDVDW--SGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGA 484 Query: 274 LSWNSYI------------------LSSGSRSGHIHHHDVRVAEHHVATLS------GHS 309 ++ + L SGS+ + D+ L+ H Sbjct: 485 VALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHD 544 Query: 310 QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE----------GGWV----PLQT--FTQ 353 +++ L +P+G+ AS D V +W E G W PL T Sbjct: 545 KDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQG 604 Query: 354 HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILW----- 407 QG+V V+ TG G D+ I++WN+ C+ + HS V ++W Sbjct: 605 EQGSVSG-------RGVVLTGSG--DKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISR 655 Query: 408 --SPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADE 465 S ++ A + +W T L H R+ +L + +ASA +D Sbjct: 656 DDSITKTKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTNILASAGSDS 715 Query: 466 TLRLWR 471 + WR Sbjct: 716 KVTFWR 721 Score = 35.8 bits (81), Expect = 0.048, Method: Compositional matrix adjust. Identities = 21/43 (48%), Positives = 26/43 (60%), Gaps = 3/43 (6%) Query: 436 VAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPA 478 VA LKGH V+SL + G +AS + D T RLWR +DPA Sbjct: 426 VALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWR---VDPA 465 Score = 28.9 bits (63), Expect = 5.5, Method: Compositional matrix adjust. Identities = 71/336 (21%), Positives = 126/336 (37%), Gaps = 81/336 (24%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW--- 253 +LA L + L ++G +L +++ GE IS++ G++L V + S ++++ Sbjct: 34 ILASTLGENAILTELNTGK--RLAEIQGDGEPISTLTITPSGSHLIVCSRSLTMRIYSLA 91 Query: 254 -----DVQQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLS 306 D + +R H+ V L+ + S +L++G+ G I D+ + + T+S Sbjct: 92 ISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDI-IGGYVTHTVS 150 Query: 307 GHSQEVCGLRWAPDGRHLAS-------------GGNDNLVNV-------WPSAPGEGGWV 346 G S V L + S G ND+ + W + G Sbjct: 151 GPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIF 210 Query: 347 PLQTFTQ-------------HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACL 393 L T H+ V+ +A+ P Q +L+ G+ D+ + +W G Sbjct: 211 DLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLS---GSRDKTMTLWLWRDG--- 264 Query: 394 SAVDAHSQVCSILW--SPHYK-ELISGHGF-----------AQNQLVIWKYPT---MAKV 436 +W +P + EL+ GF L IW T + K Sbjct: 265 ------------IWQGTPMLRHELLESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKK 312 Query: 437 AELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 + K +LS P+ + + A AD TL L+R Sbjct: 313 QDAKSEGEAILSAVSLPERSLILCAQADFTLVLYRV 348 >4YCZ-A nrPDB Length = 876 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 51/223 (22%), Positives = 84/223 (37%), Gaps = 32/223 (14%) Query: 236 KEGNYLAVGTSSAEVQLWDVQQQ--KRLRNMTSHSARVGSLSWNSY----ILSSGSRSGH 289 K GN LA +V +W +R+ + H A V +SW+ + +L+ S G+ Sbjct: 74 KYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGN 133 Query: 290 IHHHDVRVAEHHVATLSGHSQEVCGLRWAP-----------------DGRHLASGGNDNL 332 + + R + H V + WAP R +GG+DN Sbjct: 134 VSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNA 193 Query: 333 VNVWPSAPGEGGW-VPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW-----N 386 + +W P + + + T H V+ VAW P + DR +RIW N Sbjct: 194 LKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPAN 253 Query: 387 VCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWK 429 C ++ + V + WS L + G N++ +WK Sbjct: 254 PLQWNC-KVLNFDAAVWRVSWSLSGNVLAASGG--DNKVTLWK 293 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 57/202 (28%), Positives = 83/202 (41%), Gaps = 33/202 (16%) Query: 304 TLSGHSQEVCGLRWA--PDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 361 TL GH V + WA G LAS G D V +W G W + F H+ +V V Sbjct: 57 TLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIWREL--NGAWQRIFDFALHKASVNVV 114 Query: 362 AWCPWQSNVLATGGGTSDRHIRIWNVCSGACL-SAVDAHS-QVCSILWSPHYK--ELISG 417 +W P ++ L +SD ++ + + S AH V S+ W+P ++S Sbjct: 115 SWSPHEAGCL-LACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSS 173 Query: 418 H-------------GFAQNQLVIWKYPTMAKVAELK-----GHTSRVLSLTMSP---DGA 456 G + N L IW Y +L+ GHT V + SP + Sbjct: 174 KPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKS 233 Query: 457 TVASAAADETLRLWRCFELDPA 478 +ASA+ D T+R+W DPA Sbjct: 234 YIASASEDRTVRIWTS---DPA 252 >3JB9-g nrPDB Length = 558 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 39/179 (21%), Positives = 77/179 (43%), Gaps = 12/179 (6%) Query: 297 VAEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQ 355 + + H+ T GH++ + LR+ P G L SG DN + +W L+TF H Sbjct: 254 IPKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRS---LLRTFQGHA 310 Query: 356 GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV--DAHSQVCSILWSPHY-K 412 ++ +++ + L+T + D+ I++W+ G CL+ D + P Sbjct: 311 RPIRDLSFSQDGRSFLST---SFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPN 367 Query: 413 ELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 E ++G A +++ + + V H + S+T +G + + D ++R W Sbjct: 368 EFLAGT--ADKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWE 424 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 45/202 (22%), Positives = 89/202 (44%), Gaps = 17/202 (8%) Query: 279 YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 ++L SGS I +V + T GH++ + L ++ DGR S D + +W + Sbjct: 280 HLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDGRSFLSTSFDKTIKLWDT 339 Query: 339 APGEGGWVPLQTFTQHQ--GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV 396 G+ L F + VK + LA GT+D+ I +++ S + A Sbjct: 340 ELGKC----LNCFNSDRLTNCVKFQVDPDKPNEFLA---GTADKRILQFDIRSPDIVQAY 392 Query: 397 DAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPT---MAKVAELKGHTSRVLSLTMS 452 D H + SI + + K ++ + + W+Y T + VA++ H+ + + + Sbjct: 393 DHHLGGINSITFLENGKRFVTTSD--DSSMRFWEYGTPVPIKFVADIAMHS--MPRVALR 448 Query: 453 PDGATVASAAADETLRLWRCFE 474 P+G ++A + D + ++ +E Sbjct: 449 PNGKSIACQSLDNCIYVYSAYE 470 Score = 31.6 bits (70), Expect = 0.77, Method: Compositional matrix adjust. Identities = 19/79 (24%), Positives = 38/79 (48%), Gaps = 3/79 (3%) Query: 201 ALDNSVYLWSASSG---DILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQ 257 +LDN +Y++SA + ++ + Y V + +G ++ G SS WD + Sbjct: 458 SLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSPDGRFVFSGDSSGNACFWDWKT 517 Query: 258 QKRLRNMTSHSARVGSLSW 276 K + + +HS V S+++ Sbjct: 518 CKLMAKLPAHSGPVQSMAF 536 >5NZU-C nrPDB Length = 905 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 44/173 (25%), Positives = 74/173 (42%), Gaps = 12/173 (6%) Query: 302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 361 V HS + + P + + +D L+ +W + W Q F H V + Sbjct: 92 VHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD---WDKKWSCSQVFEGHTHYVMQI 148 Query: 362 AWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ--VCSILWSPHYK-ELISGH 418 P +N A+ + DR I++W + S + ++ H + C +S K LISG Sbjct: 149 VINPKDNNQFASA--SLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISG- 205 Query: 419 GFAQNQLV-IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 A ++LV IW Y V L+GH V + P+ + + + D T+R+W Sbjct: 206 --ADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIW 256 Score = 32.3 bits (72), Expect = 0.45, Method: Compositional matrix adjust. Identities = 24/100 (24%), Positives = 50/100 (50%), Gaps = 7/100 (7%) Query: 376 GTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLV-IWKYPTM 433 G D IR++N + + +AHS + I P +++ + + L+ +W + Sbjct: 75 GADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTS---SDDMLIKLWDWDKK 131 Query: 434 AKVAE-LKGHTSRVLSLTMSP-DGATVASAAADETLRLWR 471 ++ +GHT V+ + ++P D ASA+ D T+++W+ Sbjct: 132 WSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQ 171 Score = 28.5 bits (62), Expect = 6.8, Method: Compositional matrix adjust. Identities = 24/111 (21%), Positives = 43/111 (38%), Gaps = 11/111 (9%) Query: 236 KEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDV 295 K+ N A + +++W + + H V + + S G + I D Sbjct: 153 KDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDY----YSGGDKPYLISGADD 208 Query: 296 RVAE-------HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSA 339 R+ + V TL GH+Q V + P+ + +G D V +W S+ Sbjct: 209 RLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSS 259 >2HES-X nrPDB Length = 330 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 55/215 (25%), Positives = 89/215 (41%), Gaps = 29/215 (13%) Query: 191 DWSSGNVLAVALDNSVYLWSASSGD--ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSA 248 D+S G + + D + L S D ++ +L + I SVAW + LA G+ + Sbjct: 21 DFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDS 80 Query: 249 EVQLWDVQ-------QQKRLRNMTSHSARVGSLSW--NSYILSSGSR--SGHIHHHDVRV 297 V +W + + L + H V ++W + Y L++ SR S I D Sbjct: 81 TVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESG 140 Query: 298 AEHH-VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG 356 E+ ++ L HSQ+V + W P LAS D+ V +W + W + H+G Sbjct: 141 EEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDD--WECVAVLNGHEG 198 Query: 357 AVKAVAWCPWQSNVLATGG------GTSDRHIRIW 385 V W S+ T G G+ D +R+W Sbjct: 199 TV-------WSSDFDKTEGVFRLCSGSDDSTVRVW 226 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 49/210 (23%), Positives = 92/210 (43%), Gaps = 28/210 (13%) Query: 241 LAVGTSSAEVQLWDVQQQK----RLRNMTSHSARVGSLSW--NSYILSSGSRSGHI---- 290 LA G++ +++L V+ + + T+H + S++W ++ +L++GS + Sbjct: 27 LATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIWA 86 Query: 291 --HHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPL 348 D +A + GH EV G+ W+ DG +LA+ D V +W + + + Sbjct: 87 KEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECI 146 Query: 349 QTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG--ACLSAVDAHSQVCSIL 406 +H VK V W P +LA+ + D +RIW C++ ++ H + Sbjct: 147 SVLQEHSQDVKHVIWHP-SEALLAS--SSYDDTVRIWKDYDDDWECVAVLNGHE---GTV 200 Query: 407 WSPHYKE------LISGHGFAQNQLVIWKY 430 WS + + L SG + + +WKY Sbjct: 201 WSSDFDKTEGVFRLCSGSD--DSTVRVWKY 228 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 48/226 (21%), Positives = 87/226 (38%), Gaps = 56/226 (24%) Query: 261 LRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATL---SGHSQEVCGLRW 317 ++++ + ++ S ++ IL++GS I V+ + + + + H + + + W Sbjct: 7 IKSLKLYKEKIWSFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAW 66 Query: 318 APDGRHLASGGNDNLVNVW---PSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATG 374 P LA+G D+ V++W SA L H+ VK VAW LAT Sbjct: 67 RPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSN-DGYYLATC 125 Query: 375 GGTSDRHIRIWNVCSGA----CLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKY 430 + D+ + IW C+S + HSQ + VIW Sbjct: 126 --SRDKSVWIWETDESGEEYECISVLQEHSQ--------------------DVKHVIWH- 162 Query: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELD 476 P A +AS++ D+T+R+W+ ++ D Sbjct: 163 ----------------------PSEALLASSSYDDTVRIWKDYDDD 186 >4V7E-Bg nrPDB Length = 380 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 55/256 (21%), Positives = 96/256 (37%), Gaps = 56/256 (21%) Query: 228 YISSVAWI-KEGNYLAVGTSSAEVQLWDVQQQKRLRNMTS-----HSARVGSLSWNSY-- 279 Y SS ++ + L G+ LWDV +R+ S H+A V SLS NS Sbjct: 159 YASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNA 218 Query: 280 -ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 + SGS + D+R+ V T GH ++ +++ PDG+ +G +D ++ Sbjct: 219 NMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDM 278 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 G LQ + + +D + I Sbjct: 279 RTGH----QLQVYNREPDR--------------------NDNELPI-------------- 300 Query: 399 HSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL----KGHTSRVLSLTMSPD 454 V S+ +S + L + G++ +W V L H R+ L +S D Sbjct: 301 ---VTSVAFSISGRLLFA--GYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSD 355 Query: 455 GATVASAAADETLRLW 470 G+ + + + D+ L++W Sbjct: 356 GSALCTGSWDKNLKIW 371 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 48/187 (25%), Positives = 74/187 (39%), Gaps = 34/187 (18%) Query: 304 TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA--- 360 TL GHS +V L W P+ + S D + VW + +Q A+K Sbjct: 61 TLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALT-----------SQKTHAIKLHCP 109 Query: 361 -VAWCPWQSNVLATGGGTSDRHIRIWNVCSGA----------CLSAVDAHSQVCSILWSP 409 V C + N + G D I+N+ S A L+ ++ C + Sbjct: 110 WVMECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYV-PD 168 Query: 410 HYKELISGHGFAQNQLVIWKYPTMAKVAEL-----KGHTSRVLSLTM-SPDGATVASAAA 463 LI+G G V+W T +++ GHT+ VLSL++ S + S + Sbjct: 169 QETRLITGSG--DQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSC 226 Query: 464 DETLRLW 470 D T+RLW Sbjct: 227 DTTVRLW 233 >2AQ5-A nrPDB Length = 402 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 39/119 (32%), Positives = 56/119 (47%), Gaps = 11/119 (9%) Query: 298 AEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQ----TFT 352 + +V + GH+ V + W P + +ASG D V VW P G +PL+ T Sbjct: 70 VDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVW-EIPDGGLVLPLREPVITLE 128 Query: 353 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV--DAH-SQVCSILWS 408 H V VAW P NVL + G D I +W+V +GA + + D H + S+ WS Sbjct: 129 GHTKRVGIVAWHPTAQNVLLSAG--CDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWS 185 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 41/164 (25%), Positives = 73/164 (44%), Gaps = 25/164 (15%) Query: 346 VPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGAC-------LSAVDA 398 VPL H V +AWCP NV+A+ G+ D + +W + G + ++ Sbjct: 74 VPL--VCGHTAPVLDIAWCPHNDNVIAS--GSEDCTVMVWEIPDGGLVLPLREPVITLEG 129 Query: 399 HSQVCSIL-WSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL--KGHTSRVLSLTMSPDG 455 H++ I+ W P + ++ G N +++W T A V L H + S+ S DG Sbjct: 130 HTKRVGIVAWHPTAQNVLLSAG-CDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDG 188 Query: 456 ATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR 499 A + ++ D+ +R+ ++P R+ A+ H+G R Sbjct: 189 ALICTSCRDKRVRV-----IEP-----RKGTVVAEKDRPHEGTR 222 >5WJC-A nrPDB Length = 430 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 41/162 (25%), Positives = 71/162 (43%), Gaps = 19/162 (11%) Query: 241 LAVGTSSAEVQLWDVQ---QQKRLRNMTSHSARVGSLS---WNSYILSSGSRSGHIHHHD 294 LA + +Q+ D + +++ + + +HS + +++ +N Y+L++ S + D Sbjct: 251 LASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWD 310 Query: 295 VRVAEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVW----------PSAPGEG 343 +R + TL GH EV GL W+P D LAS D V +W P +G Sbjct: 311 LRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDG 370 Query: 344 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW 385 L H + +WCP + V+ G D ++IW Sbjct: 371 SPELLFMHGGHTNRISEFSWCPNERWVV--GSLADDNILQIW 410 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 59/248 (23%), Positives = 94/248 (37%), Gaps = 53/248 (21%) Query: 241 LAVGTSSAEVQLWDVQQQKRLRNMTS----------HSARVGSLSWN---SYILSSGSRS 287 LA G + LWDVQ Q + T H+ V + ++ +L+S S Sbjct: 198 LATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDD 257 Query: 288 GHIHHHDVRV--AEHHVATLSGHSQEVCGLRWAPDGRHL-ASGGNDNLVNVWPSAPGEGG 344 + HD R+ E + HS+ + + P +L A+ D V +W Sbjct: 258 CTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDL---RNP 314 Query: 345 WVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAVDAHSQVC 403 + L T H+ V + W P +LA+ ++DR + IW++ G + DA Sbjct: 315 YQRLHTLEGHEDEVYGLEWSPHDEPILASS--STDRRVCIWDLEKIGEEQTPEDAEDG-- 370 Query: 404 SILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVASAA 462 SP EL+ HG GHT+R+ + P+ V S A Sbjct: 371 ----SP---ELLFMHG---------------------GHTNRISEFSWCPNERWVVGSLA 402 Query: 463 ADETLRLW 470 D L++W Sbjct: 403 DDNILQIW 410 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 42/205 (20%), Positives = 82/205 (40%), Gaps = 10/205 (4%) Query: 303 ATLSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWP------SAPGEGGWVPLQTFTQHQ 355 A L GH+ E GL W P+ +LA+G D ++ +W ++ P+ + +H Sbjct: 176 AVLKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHT 235 Query: 356 GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC-SGACLSAVDAHSQVCSILWSPHYKEL 414 V V + P +LA+ I + + AHS+ + + + + Sbjct: 236 DIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDY 295 Query: 415 ISGHGFAQNQLVIWKYPT-MAKVAELKGHTSRVLSLTMSP-DGATVASAAADETLRLWRC 472 + A + +W ++ L+GH V L SP D +AS++ D + +W Sbjct: 296 LLATASADKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDL 355 Query: 473 FELDPARRREREKASAAKSSLIHQG 497 ++ + E + + + +H G Sbjct: 356 EKIGEEQTPEDAEDGSPELLFMHGG 380 >4L9O-A nrPDB Length = 349 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 46/168 (27%), Positives = 69/168 (41%), Gaps = 14/168 (8%) Query: 232 VAWI--KEGNYLAVGTSSAEVQLW--DVQQQKRLRNMTSHSARVGSLSWNSY----ILSS 283 VAW K G LA + +V +W D ++ + H A V S+SW + +L Sbjct: 119 VAWAHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLC 178 Query: 284 GSRSGHIHHHDVRVA-EHHVATLSGHSQEVCGLRWAP-----DGRHLASGGNDNLVNVWP 337 S G I + + + GH+ V WAP + R SGG DNLV +W Sbjct: 179 ASSDGKISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWR 238 Query: 338 SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW 385 ++ + F H V+ VAW P + + + DR + IW Sbjct: 239 YDDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIW 286 >3JB9-L nrPDB Length = 340 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 38/182 (20%), Positives = 79/182 (43%), Gaps = 11/182 (6%) Query: 303 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 L+G + L+W+ D R + +D + W + G+ ++ H G V A+ Sbjct: 87 GVLNGCKGAITDLQWSRDSRVVYCSSSDTHLMSWDAVSGQ----KIRKHKGHAGVVNALD 142 Query: 363 WCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQ 422 S +L + + D +++W+ S C+ ++ + ++ + ++ G Sbjct: 143 VLKVGSELLTSV--SDDCTMKVWDSRSKDCIKTIEEKYPLTAVAIAQQGTQVFIGG--ID 198 Query: 423 NQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRRE 482 + IW LKGH + SL +S DG+++ S + D T+R+ F++ P + Sbjct: 199 GAIKIWDLRNNHCSHVLKGHKDIITSLAISKDGSSLLSNSMDNTVRI---FDVKPFASAQ 255 Query: 483 RE 484 R+ Sbjct: 256 RQ 257 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 41/203 (20%), Positives = 80/203 (39%), Gaps = 51/203 (25%) Query: 187 LNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTS 246 L+++ S + +V+ D ++ +W + S D ++ ++ + P +++VA ++G + +G Sbjct: 141 LDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIEEKYP---LTAVAIAQQGTQVFIGGI 197 Query: 247 SAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLS 306 +++WD+ R+ H H L Sbjct: 198 DGAIKIWDL------------------------------RNNHCSH-----------VLK 216 Query: 307 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA----VA 362 GH + L + DG L S DN V ++ P LQ F +GA+ + Sbjct: 217 GHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIF---EGAIHGQEHNLL 273 Query: 363 WCPWQSNVLATGGGTSDRHIRIW 385 W N G G+SD+++ +W Sbjct: 274 GVAWSRNSRFVGAGSSDKNVYVW 296 Score = 31.6 bits (70), Expect = 0.76, Method: Compositional matrix adjust. Identities = 13/36 (36%), Positives = 18/36 (50%) Query: 438 ELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 ++ GHT+ VL P G+ AS D + LW F Sbjct: 45 QMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVF 80 >3CFV-B nrPDB Length = 414 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 43/159 (27%), Positives = 74/159 (46%), Gaps = 19/159 (11%) Query: 194 SGNVLAVALDNSVYLWSASSG-------DILQLLQMEQPGEYISSVAW--IKEGNYLAVG 244 SG++L+ + D++V LW ++G D + + VAW + E + +V Sbjct: 192 SGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSA--VVEDVAWHLLHESLFGSVA 249 Query: 245 TSSAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWNSY---ILSSGSRSGHIHHHDVRVA 298 ++ +WD + K + +H+A V LS+N Y IL++GS + D+R Sbjct: 250 -DDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 308 Query: 299 EHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW 336 + + T H E+ + W+P LAS G D +NVW Sbjct: 309 KLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVW 347 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 56/250 (22%), Positives = 99/250 (39%), Gaps = 50/250 (20%) Query: 240 YLAVGTSSAEVQLWDVQ---QQKRLRN----MTSHSARVGSLSWN---SYILSSGSRSGH 289 +L + V LWD+ ++ ++ + T HSA V ++W+ + S + Sbjct: 194 HLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQK 253 Query: 290 IHHHDVR--VAEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWV 346 + D R + H+ EV L + P LA+G D V +W + + Sbjct: 254 LMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK---L 310 Query: 347 PLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAVDAHSQVCSI 405 L TF H+ + V W P +LA+ G +DR + +W++ G SA DA Sbjct: 311 KLHTFESHKDEIFQVHWSPHNETILASSG--TDRRLNVWDLSKIGEEQSAEDAED----- 363 Query: 406 LWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVASAAAD 464 P EL+ HG GHT+++ + +P+ + S + D Sbjct: 364 --GP--PELLFIHG---------------------GHTAKISDFSWNPNEPWVICSVSED 398 Query: 465 ETLRLWRCFE 474 +++W+ E Sbjct: 399 NIMQIWQMAE 408 >6CHG-A nrPDB Length = 312 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 37/162 (22%), Positives = 74/162 (45%), Gaps = 11/162 (6%) Query: 237 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHD 294 +G +A+ + ++ ++++ K ++ T+H + L W +S ++SGS + Sbjct: 24 DGELIAI-CQNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSKCIASGSEDFTVEI-- 80 Query: 295 VRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQH 354 + + L GH+ V + + G L S D + W G L+T + H Sbjct: 81 THIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTA----LKTMSAH 136 Query: 355 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV 396 AV ++ + S++L++ G+ D IRI++ SG CL + Sbjct: 137 SDAVVSIDIPKFDSSILSS--GSYDGLIRIFDTESGHCLKTL 176 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 42/168 (25%), Positives = 76/168 (45%), Gaps = 17/168 (10%) Query: 187 LNLVDWS--SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVG 244 +N + WS S + + + D +V + G I +L+ P + S+ + +GN L Sbjct: 57 INCLCWSPDSKCIASGSEDFTVEITHIIYGRIRRLMGHTAP---VISICYNNKGNILCSS 113 Query: 245 TSSAEVQLWDVQQQKRLRNMTSHSARVGSLS---WNSYILSSGSRSGHIHHHDVRVAEHH 301 + ++ W V L+ M++HS V S+ ++S ILSSGS G I D + H Sbjct: 114 SMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTE-SGHC 172 Query: 302 VATLSGHSQ--------EVCGLRWAPDGRHLASGGNDNLVNVWPSAPG 341 + TL+ + ++++ +G+ L DN+V +W G Sbjct: 173 LKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRG 220 Score = 37.0 bits (84), Expect = 0.018, Method: Compositional matrix adjust. Identities = 37/183 (20%), Positives = 71/183 (38%), Gaps = 34/183 (18%) Query: 306 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 365 + H + + L W+PD + +ASG D V + G ++ H V ++ + Sbjct: 51 TTHKECINCLCWSPDSKCIASGSEDFTVEITHIIYGR-----IRRLMGHTAPVISICY-N 104 Query: 366 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQL 425 + N+L + + D I+ W+V SG L + AHS + P + I G Sbjct: 105 NKGNILCSS--SMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSG------ 156 Query: 426 VIWKYPTMAKVAELK-GHTSRVL----------------SLTMSPDGATVASAAADETLR 468 Y + ++ + + GH + L ++ S +G + + D ++ Sbjct: 157 ---SYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVK 213 Query: 469 LWR 471 LW Sbjct: 214 LWE 216 Score = 35.8 bits (81), Expect = 0.045, Method: Compositional matrix adjust. Identities = 21/88 (23%), Positives = 44/88 (50%), Gaps = 4/88 (4%) Query: 384 IWNVCSGACLSAVDAHSQVCSIL-WSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGH 442 ++ + S + H + + L WSP K + SG +++ V + ++ L GH Sbjct: 38 VYEISSSKMMKLTTTHKECINCLCWSPDSKCIASG---SEDFTVEITHIIYGRIRRLMGH 94 Query: 443 TSRVLSLTMSPDGATVASAAADETLRLW 470 T+ V+S+ + G + S++ DE+++ W Sbjct: 95 TAPVISICYNNKGNILCSSSMDESIKEW 122 >3JAP-g nrPDB Length = 326 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 63/257 (24%), Positives = 100/257 (38%), Gaps = 30/257 (11%) Query: 237 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHD 294 +GNY + ++LW++ H+ V S++ NS + S SR I + Sbjct: 77 DGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISASRDKTIRVWN 136 Query: 295 VRVAEHHVATLSGHSQEVCGLRWAP---------DGR-HLASGGNDNLVNVWPSAPGEGG 344 +V L GH+ V +R AP DGR S G D +V W + E Sbjct: 137 TVGDCAYV--LLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSW--SLNEDS 192 Query: 345 WVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCS 404 + F H + V P LA G D I +WN+ + DA +V + Sbjct: 193 YRIEADFIGHNNYINVVQPSP--DGSLAASAG-KDGQIYVWNLKHKSAFMNFDAKDEVFA 249 Query: 405 ILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK----GHTS----RVLSLTMSPDGA 456 + +SP L + + + I+ + ELK G+T +SL S DG Sbjct: 250 LAFSPSRFWLTAA---TASGIKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQ 306 Query: 457 TVASAAADETLRLWRCF 473 T+ + D +R+W+ Sbjct: 307 TLFAGYTDNVIRVWQVM 323 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 45/186 (24%), Positives = 73/186 (39%), Gaps = 27/186 (14%) Query: 302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 361 V + GHS V + + DG + S D + +W A G F H G V +V Sbjct: 59 VRSYKGHSHIVQDVVVSADGNYAVSASWDKTLRLWNLATGNSE----ARFVGHTGDVLSV 114 Query: 362 AWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGF 420 A S +++ + D+ IR+WN G C + H+ V + +P E G Sbjct: 115 AIDANSSKIIS---ASRDKTIRVWNTV-GDCAYVLLGHTDWVTKVRVAPKNLE----DGE 166 Query: 421 AQNQLVIWKYPTMAKV--------------AELKGHTSRVLSLTMSPDGATVASAAADET 466 + + + M K+ A+ GH + + + SPDG+ ASA D Sbjct: 167 VDDGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQ 226 Query: 467 LRLWRC 472 + +W Sbjct: 227 IYVWNL 232 Score = 37.0 bits (84), Expect = 0.018, Method: Compositional matrix adjust. Identities = 31/129 (24%), Positives = 56/129 (43%), Gaps = 10/129 (7%) Query: 350 TFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-----GACLSAVDAHSQVC- 403 T H G V +++ Q N+L +G + D+ + W + G + + HS + Sbjct: 13 TLEGHNGWVTSLSTSAAQPNLLVSG--SRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQ 70 Query: 404 SILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAA 463 ++ S +S L +W T A GHT VLS+ + + + + SA+ Sbjct: 71 DVVVSADGNYAVSASW--DKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISASR 128 Query: 464 DETLRLWRC 472 D+T+R+W Sbjct: 129 DKTIRVWNT 137 Score = 28.9 bits (63), Expect = 5.2, Method: Compositional matrix adjust. Identities = 25/118 (21%), Positives = 57/118 (48%), Gaps = 11/118 (9%) Query: 228 YISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--SYILSSGS 285 YI+ V +G+ A ++ +W+++ + N + V +L+++ + L++ + Sbjct: 205 YINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDAKD-EVFALAFSPSRFWLTAAT 263 Query: 286 RSGHIHHHDVR---VAEHHVATLSGHSQ----EVCGLRWAPDGRHLASGGNDNLVNVW 336 SG I +D+ + + +G+++ L W+ DG+ L +G DN++ VW Sbjct: 264 ASG-IKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVW 320 >5BJS-A nrPDB Length = 605 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 39/159 (24%), Positives = 74/159 (46%), Gaps = 17/159 (10%) Query: 211 ASSGDILQLLQMEQPGEYISSVAW----IKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTS 266 A+ +I+QL++ + E + W I + L + + V++++V + K R + Sbjct: 118 ANPCEIIQLIR-DDGNEANCASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLVG 176 Query: 267 HSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHH----VATL--SGHSQEVCGLRW 317 H + L+ N YI++S S I + EH V L GHS ++ + + Sbjct: 177 HGGGINDLATSPANPYIIASASDDTTIRIWSL-APEHEKQPCVCILGGEGHSYDLLSVAF 235 Query: 318 APDGRHLASGGNDNLVNVW--PSAPGEGGWVPLQTFTQH 354 +GR++ S G+D ++N+W P P E +P+ + H Sbjct: 236 HDNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPH 274 Score = 28.5 bits (62), Expect = 7.1, Method: Compositional matrix adjust. Identities = 22/102 (21%), Positives = 40/102 (39%), Gaps = 8/102 (7%) Query: 381 HIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIW-------KYPTM 433 +++++NV G + H + L + I + IW K P + Sbjct: 159 NVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCV 218 Query: 434 AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFEL 475 + +GH+ +LS+ +G V SA D+ + LW E Sbjct: 219 CILGG-EGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEF 259 >4XYI-A nrPDB Length = 430 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 61/255 (23%), Positives = 102/255 (40%), Gaps = 54/255 (21%) Query: 234 WIKEGNYLAVGTSSAEVQLWDVQQQKR----------LRNMTSHSARVGSLSW---NSYI 280 +I+EG LA GT + +WD++ + + H+A V L + + + Sbjct: 192 FIQEGT-LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEAL 250 Query: 281 LSSGSRSGHIHHHDVRVAEHHVAT--LSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVWP 337 L+S S + HD R+ A+ + H Q V G+ + P + LA+ D+ V +W Sbjct: 251 LTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWD 310 Query: 338 SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAV 396 L T H+ V V W P +L T ++DR + +W++ G + Sbjct: 311 LRRLNQR---LHTLEGHEDEVYNVQWSPHDEPILVT--SSTDRRVCVWDLSKIGEEQTVE 365 Query: 397 DAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA 456 D+ EL+ HG GHT+RV L+ +P+ Sbjct: 366 DSEDGA---------PELMFMHG---------------------GHTNRVSDLSWNPNNK 395 Query: 457 -TVASAAADETLRLW 470 +AS A D L++W Sbjct: 396 WVLASLADDNILQIW 410 >5K0Y-T nrPDB Length = 329 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 31/101 (30%), Positives = 50/101 (49%), Gaps = 13/101 (12%) Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 L GH + + +++ +G L + D +VNVW S GE L T+ H GAV WC Sbjct: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGE----RLGTYMGHTGAV----WC 57 Query: 365 ---PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV 402 W + + T G++D R+W+ +G L+ + +S V Sbjct: 58 VDADWDTKHVLT--GSADNSCRLWDCETGKQLALLKTNSAV 96 Score = 36.6 bits (83), Expect = 0.024, Method: Compositional matrix adjust. Identities = 32/165 (19%), Positives = 68/165 (41%), Gaps = 17/165 (10%) Query: 191 DWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS--- 247 DW + +VL + DNS LW +G L LL+ + + + GN + T Sbjct: 61 DWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSA---VRTCGFDFGGNIIMFSTDKQMG 117 Query: 248 --AEVQLWDVQQQKRLRN------MTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRV 297 V +D++ ++ N + + +++ S W + +G SG ++ + + Sbjct: 118 YQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKS 177 Query: 298 AEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE 342 E V + HS+++ ++ + + + DN ++ S E Sbjct: 178 GEVLV-NVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLE 221 Score = 33.5 bits (75), Expect = 0.21, Method: Compositional matrix adjust. Identities = 26/141 (18%), Positives = 55/141 (39%), Gaps = 16/141 (11%) Query: 209 WSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWD---VQQQKRLRNMT 265 +SA SG++L + +++ I+ + +E + +L+D ++ QK R Sbjct: 173 YSAKSGEVL--VNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEP 230 Query: 266 SHSARVGSLSWNSYILSSGSRSGHIHHHDVRVA-----------EHHVATLSGHSQEVCG 314 S ++ ++ G + + R+ E + GH + Sbjct: 231 PRELAALSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINS 290 Query: 315 LRWAPDGRHLASGGNDNLVNV 335 + + PDG+ +SGG D V + Sbjct: 291 VAFHPDGKSYSSGGEDGYVRI 311 Score = 28.5 bits (62), Expect = 8.0, Method: Compositional matrix adjust. Identities = 13/46 (28%), Positives = 20/46 (43%) Query: 427 IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 +W ++ GHT V + D V + +AD + RLW C Sbjct: 36 VWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDC 81 >6EMK-B nrPDB Length = 303 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 37/179 (20%), Positives = 67/179 (37%), Gaps = 22/179 (12%) Query: 302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW----PSAPGEGGWVPLQTFTQHQGA 357 VA+ GH V + + D R + + D + VW PS P +H Sbjct: 68 VASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRN---------YKHNAP 118 Query: 358 VKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISG 417 V V P Q +++ D +IRIW++ C + S + Sbjct: 119 VNEVVIHPNQGELISCD---RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLA 175 Query: 418 HGFAQNQLVIWKYPT------MAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 + +W+ P + V + + H++ + + +S D +A+ +AD T R+W Sbjct: 176 AANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW 234 Score = 35.4 bits (80), Expect = 0.053, Method: Compositional matrix adjust. Identities = 24/103 (23%), Positives = 45/103 (43%), Gaps = 2/103 (1%) Query: 368 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVI 427 S +L + G D IR W +G C + + L + K+L++ G +L Sbjct: 2 SVILVSAG--YDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYD 59 Query: 428 WKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 + VA +GH V S++ D + +++ D T+++W Sbjct: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW 102 Score = 29.6 bits (65), Expect = 3.1, Method: Compositional matrix adjust. Identities = 63/306 (20%), Positives = 118/306 (38%), Gaps = 29/306 (9%) Query: 143 GYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVAL 202 GY + ++ +A G +T ++ S +R+ EI ND L LA A Sbjct: 9 GYDHTIRFW---EALTGVCSRTIQHSDSQVNRL----EITNDKKL----------LATAG 51 Query: 203 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLR 262 +V L+ + + + E ++SV++ ++ ++ + +++WDV+ R Sbjct: 52 HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPR 111 Query: 263 NMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD 320 N H+A V + N L S R G+I D+ + + L A D Sbjct: 112 NY-KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASD 170 Query: 321 GRHLASGGNDNLVNVW--PSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTS 378 G LA+ VW P+ P+ F H + + S+V ++ Sbjct: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRIL---LSSDVKHLATCSA 227 Query: 379 DRHIRIWNVCSGACL-SAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKV 436 D R+W++ L + +D H + V +S L++ + + + +W T V Sbjct: 228 DHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTAS--SDHYVRLWDLSTREIV 285 Query: 437 AELKGH 442 + GH Sbjct: 286 RQYGGH 291 Score = 28.1 bits (61), Expect = 9.1, Method: Compositional matrix adjust. Identities = 34/176 (19%), Positives = 65/176 (36%), Gaps = 20/176 (11%) Query: 195 GNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWD 254 G +++ D ++ +W L E + S++ +G+ LA + +W+ Sbjct: 129 GELISCDRDGNIRIWDLGENQCTHQLTPEDDTS-LQSLSMASDGSMLAAANTKGNCYVWE 187 Query: 255 VQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHV------------ 302 + SH V +S ++ S + H A+H Sbjct: 188 MPNHTD----ASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLE 243 Query: 303 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAV 358 TL GH + V ++ D +L + +D+ V +W + E + Q H+GAV Sbjct: 244 TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTRE---IVRQYGGHHKGAV 296 >5YZG-W nrPDB Length = 579 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 43/194 (22%), Positives = 81/194 (41%), Gaps = 9/194 (4%) Query: 279 YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 ++L S S I +V + T GHS+ V + + G S D + +W + Sbjct: 302 HLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDT 361 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 G+ + FT + V + P + G SD+ I W++ SG + D Sbjct: 362 ETGQC----ISRFTNRK-VPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDR 416 Query: 399 H-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAK-VAELKGHTSRVLSLTMSPDGA 456 H V +I++ + +S ++ W P K +AE H+ + ++T+SP+G Sbjct: 417 HLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHS--MPAVTLSPNGK 474 Query: 457 TVASAAADETLRLW 470 +A + D + ++ Sbjct: 475 WLACQSMDNQILIF 488 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 48/279 (17%), Positives = 96/279 (34%), Gaps = 52/279 (18%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256 L+ A D + LW +G + + + + N G S ++ WD++ Sbjct: 347 FLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIR 406 Query: 257 QQKRLRNMTSHSARVGSLSW----NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEV 312 + ++ H V ++ + ++ +S +S + D+ V ++A S HS Sbjct: 407 SGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPA 466 Query: 313 CGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLA 372 L +P+G+ LA DN + ++ Sbjct: 467 VTL--SPNGKWLACQSMDNQILIF------------------------------------ 488 Query: 373 TGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPT 432 G + + + G ++ C + +SP +ISG G +L IW + T Sbjct: 489 --GAQNRFRLNKKKIFKGHMVAGY-----ACQVDFSPDMSYVISGDG--NGKLNIWDWKT 539 Query: 433 MAKVAELKGHTSRVLSLTMSP-DGATVASAAADETLRLW 470 + K H + P + + V + D ++LW Sbjct: 540 TKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLW 578 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 46/208 (22%), Positives = 83/208 (39%), Gaps = 24/208 (11%) Query: 191 DWSSGNVLAVAL-DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTS--- 246 D N+ + D + W SG+I+Q + ++ ++++ ++ E N V TS Sbjct: 384 DEDKQNLFVAGMSDKKIVQWDIRSGEIVQ--EYDRHLGAVNTIVFVDE-NRRFVSTSDDK 440 Query: 247 SAEVQLWDVQQQ-KRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDV--RVAEHHVA 303 S V WD+ K + + HS +LS N L+ S I R + Sbjct: 441 SLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKK 500 Query: 304 TLSGH--SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQT---FTQHQGAV 358 GH + C + ++PD ++ SG + +N+W W + F H Sbjct: 501 IFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIW-------DWKTTKLYSRFKAHDKVC 553 Query: 359 KAVAWCPWQSNVLATGGGTSDRHIRIWN 386 W P +++ + T G D I++W+ Sbjct: 554 IGAVWHPHETSKVITCGW--DGLIKLWD 579 >6QDV-o nrPDB Length = 513 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 43/194 (22%), Positives = 81/194 (41%), Gaps = 9/194 (4%) Query: 279 YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 ++L S S I +V + T GHS+ V + + G S D + +W + Sbjct: 236 HLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDT 295 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 G+ + FT + V + P + G SD+ I W++ SG + D Sbjct: 296 ETGQC----ISRFTNRK-VPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDR 350 Query: 399 H-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAK-VAELKGHTSRVLSLTMSPDGA 456 H V +I++ + +S ++ W P K +AE H+ + ++T+SP+G Sbjct: 351 HLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHS--MPAVTLSPNGK 408 Query: 457 TVASAAADETLRLW 470 +A + D + ++ Sbjct: 409 WLACQSMDNQILIF 422 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 48/279 (17%), Positives = 96/279 (34%), Gaps = 52/279 (18%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256 L+ A D + LW +G + + + + N G S ++ WD++ Sbjct: 281 FLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIR 340 Query: 257 QQKRLRNMTSHSARVGSLSW----NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEV 312 + ++ H V ++ + ++ +S +S + D+ V ++A S HS Sbjct: 341 SGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPA 400 Query: 313 CGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLA 372 L +P+G+ LA DN + ++ Sbjct: 401 VTL--SPNGKWLACQSMDNQILIF------------------------------------ 422 Query: 373 TGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPT 432 G + + + G ++ C + +SP +ISG G +L IW + T Sbjct: 423 --GAQNRFRLNKKKIFKGHMVAGY-----ACQVDFSPDMSYVISGDG--NGKLNIWDWKT 473 Query: 433 MAKVAELKGHTSRVLSLTMSP-DGATVASAAADETLRLW 470 + K H + P + + V + D ++LW Sbjct: 474 TKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLW 512 Score = 33.5 bits (75), Expect = 0.20, Method: Compositional matrix adjust. Identities = 46/208 (22%), Positives = 83/208 (39%), Gaps = 24/208 (11%) Query: 191 DWSSGNVLAVAL-DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTS--- 246 D N+ + D + W SG+I+Q + ++ ++++ ++ E N V TS Sbjct: 318 DEDKQNLFVAGMSDKKIVQWDIRSGEIVQ--EYDRHLGAVNTIVFVDE-NRRFVSTSDDK 374 Query: 247 SAEVQLWDVQQQ-KRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDV--RVAEHHVA 303 S V WD+ K + + HS +LS N L+ S I R + Sbjct: 375 SLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKK 434 Query: 304 TLSGH--SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQT---FTQHQGAV 358 GH + C + ++PD ++ SG + +N+W W + F H Sbjct: 435 IFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIW-------DWKTTKLYSRFKAHDKVC 487 Query: 359 KAVAWCPWQSNVLATGGGTSDRHIRIWN 386 W P +++ + T G D I++W+ Sbjct: 488 IGAVWHPHETSKVITCGW--DGLIKLWD 513 >5XYI-g nrPDB Length = 335 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 36/165 (21%), Positives = 59/165 (35%), Gaps = 48/165 (29%) Query: 307 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW 366 GH ++V G+ ++P R + S G DN V +W +++ ++ +W Sbjct: 120 GHKKDVLGVTFSPCNRRIISVGRDNQVKIW------------NILGENKAELQCSSW--- 164 Query: 367 QSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLV 426 V S AC D S L+ G ++ Sbjct: 165 --------------------VTSVACAPMADETS------------PLVIAVGCWDGKVY 192 Query: 427 IWKYPTMAK-VAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 IW AK + E K H R S+ +PDG V + +D + +W Sbjct: 193 IWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMW 237 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 37/159 (23%), Positives = 64/159 (40%), Gaps = 12/159 (7%) Query: 189 LVDWSSGNVLAVAL-DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247 + D +S V+AV D VY+WS L + + + +SV + +G ++ G S Sbjct: 173 MADETSPLVIAVGCWDGKVYIWSIEKEAKL-IKEFKAHDGRCTSVDFTPDGKWVITGGSD 231 Query: 248 AEVQLWDVQQQKRLRNMTSHS-----ARVGSLSWNSYILSSGSRSGHI-HHHDVRVAE-- 299 +V +W + + + T+ S A + +W G I + + + Sbjct: 232 RKVVMWLTENGAKTISFTAPSPVHAVAACPTQAWICAATYEGIAVWDIGAKQQIDLVQPN 291 Query: 300 --HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 336 H +G + + L WA DG L SG ND + W Sbjct: 292 FKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIRAW 330 >2PM9-A nrPDB Length = 416 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 63/296 (21%), Positives = 122/296 (41%), Gaps = 30/296 (10%) Query: 194 SGNVLA-VALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 252 SG V A + D+S+ LWS + D + + Q + + W +A + ++L Sbjct: 34 SGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHNNKIIAGALDNGSLEL 93 Query: 253 WDVQQQKRLRN----MTSHSARVGSLSWNSY---ILSSGSRSGHIHHHDVRVA----EHH 301 + + N ++HS+ V ++ +N+ +L+SG +G I D+ ++ Sbjct: 94 YSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNY 153 Query: 302 VATLSGHS----QEVCGLRWAPDGRH-LASGGNDNLVNVWP-SAPGEGGWVPLQTFTQHQ 355 G S EV L W H AS G+ N ++W A E V ++T Sbjct: 154 TPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKE---VIHLSYTSPN 210 Query: 356 GAVK----AVAWCPWQSNVLATGGGT-SDRHIRIWNVCSGAC-LSAVDAHSQ--VCSILW 407 +K V W P S +AT G+ +D I IW++ + L ++ Q + S+ W Sbjct: 211 SGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDW 270 Query: 408 SPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAA 463 + L+ G N +++W + ++++ + +P+ + + A+ Sbjct: 271 CHQDEHLLLSSG-RDNTVLLWNPESAEQLSQFPARGNWCFKTKFAPEAPDLFACAS 325 >6BX3-A nrPDB Length = 314 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 40/163 (24%), Positives = 72/163 (44%), Gaps = 17/163 (10%) Query: 192 WS-SGNVLAVALDN-SVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE 249 WS G +A A D+ SV + S G + + P + S+ + ++GN L + Sbjct: 62 WSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAP---VISLTFNRKGNLLFTSSMDES 118 Query: 250 VQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVATLS 306 +++WD ++ +++HS V S+ +S ILSSGS G I D H + TL+ Sbjct: 119 IKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG-HCLKTLT 177 Query: 307 GHSQ--------EVCGLRWAPDGRHLASGGNDNLVNVWPSAPG 341 + ++++ + R+L D +V +W G Sbjct: 178 YDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGG 220 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 26/97 (26%), Positives = 50/97 (51%), Gaps = 8/97 (8%) Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 ++ H++ L W+PDG+ +A+ +D V + + G L TF H V ++ + Sbjct: 50 VTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG-----LLHTFIGHTAPVISLTF- 103 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ 401 + N+L T + D I+IW+ +G+ + + AHS+ Sbjct: 104 NRKGNLLFTS--SMDESIKIWDTLNGSLMKTISAHSE 138 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 11/30 (36%), Positives = 22/30 (73%) Query: 441 GHTSRVLSLTMSPDGATVASAAADETLRLW 470 GHT+ V+SLT + G + +++ DE++++W Sbjct: 93 GHTAPVISLTFNRKGNLLFTSSMDESIKIW 122 >4XFV-A nrPDB Length = 792 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 47/188 (25%), Positives = 73/188 (38%), Gaps = 25/188 (13%) Query: 303 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 ATL GH EV +R+ PD + S D+ V +W +QT + + A++ Sbjct: 57 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFT-DYSHLQCIQTIQHYSKTIVALS 115 Query: 363 WCPWQSNVLATGGGTSDRHIRIW--NVCSGACLSAVDAHSQ------VCSILWSPHYKEL 414 P +V G +D I IW N+ + A + + +C L K+ Sbjct: 116 ALPSLISV-----GCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKY 170 Query: 415 ISGHGFAQNQLVIWKY-------PTMAKVAELKGHTSRVLSLTM----SPDGATVASAAA 463 + G + I + VAEL+GH V SL +P + S + Sbjct: 171 LLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQ 230 Query: 464 DETLRLWR 471 D +RLWR Sbjct: 231 DRYIRLWR 238 Score = 35.0 bits (79), Expect = 0.076, Method: Compositional matrix adjust. Identities = 47/216 (21%), Positives = 75/216 (34%), Gaps = 37/216 (17%) Query: 217 LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW 276 L E PG+Y+ L G+ ++LW ++ + + S ++ LS Sbjct: 212 LAFRHQETPGDYL-----------LCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSN 260 Query: 277 NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 336 Y ++RV + A + GH + L+W L + D + VW Sbjct: 261 KQYKFQIDD--------ELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVW 312 Query: 337 PSAPGEGGWVPLQTFTQH--QGAVKAVA-----W-CPW----QSNVLATGGGTSDRHIRI 384 G WV + +GA A W C W + + T G T R+ Sbjct: 313 EPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSW--RM 370 Query: 385 W----NVCSGACLSAVDAHSQVCSILWSPHYKELIS 416 W N+ L A V I WSP + L++ Sbjct: 371 WATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLA 406 Score = 33.1 bits (74), Expect = 0.28, Method: Compositional matrix adjust. Identities = 52/264 (19%), Positives = 102/264 (38%), Gaps = 37/264 (14%) Query: 229 ISSVAWIKEGNYLAVGTSSAEVQLW---DVQQQKRLRNMTSHSARVGSLSWNSYILSSGS 285 ++ V ++ + +++ + V++W D + ++ + +S + +LS ++S G Sbjct: 66 VTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGC 125 Query: 286 RSGHIH------HHDVRVAEHHVATLSGHSQEVC-GLRWAPDGRHLASGGNDNLVNVWP- 337 G I +D H G +C L + ++L + G N VNV+ Sbjct: 126 ADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTN-VNVFIA 184 Query: 338 ----SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS-NVLATGGGTSDRHIRIWNVCSGAC 392 S G + H+ VK++A+ ++ G+ DR+IR+W + Sbjct: 185 SFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL 244 Query: 393 LSAVDAHSQVCSILWSPHYK-----ELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVL 447 + + S+ ++L + YK EL G F A + GH + Sbjct: 245 IDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFE---------------ALIMGHDDWIS 289 Query: 448 SLTMSPDGATVASAAADETLRLWR 471 SL + +A AD +L +W Sbjct: 290 SLQWHESRLQLLAATADTSLMVWE 313 >5K19-A nrPDB Length = 569 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 40/175 (22%), Positives = 76/175 (43%), Gaps = 27/175 (15%) Query: 205 SVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRN- 263 S++L + SSG++ G +K+G AV T + K RN Sbjct: 163 SLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTC----------KSKSTRNP 212 Query: 264 MTSHSARVGSLSWNSY-----ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWA 318 + + G+L+ ++ L+ S+ G + + E H T+ + + + W+ Sbjct: 213 LLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELH-GTMKSYFGGLLCVCWS 271 Query: 319 PDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ---HQGAVKAVAWCPWQSNV 370 PDG+++ +GG D+LV VW +V + + H+ V VA+ P+ ++V Sbjct: 272 PDGKYIVTGGEDDLVTVW-------SFVDCRVIARGHGHKSWVSVVAFDPYTTSV 319 >5OQL-X nrPDB Length = 630 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 23/96 (23%), Positives = 49/96 (51%), Gaps = 7/96 (7%) Query: 304 TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAW 363 T GH + ++ + DG+ + +GG D + V+ +A P++ FTQH+ AV +A+ Sbjct: 241 TYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAAD----LKPIKAFTQHRDAVTGLAF 296 Query: 364 CPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH 399 + + + + DR +++W++ A + + H Sbjct: 297 RRGTNQLYSC---SKDRTVKVWSLDELAYVETLFGH 329 Score = 33.9 bits (76), Expect = 0.17, Method: Compositional matrix adjust. Identities = 33/134 (24%), Positives = 55/134 (41%), Gaps = 27/134 (20%) Query: 354 HQGAVKA--VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHY 411 +QG +KA V + TGG +D+ + ++N A L + A +Q + Sbjct: 242 YQGHLKAPLVVKASQDGKFVVTGG--ADKRLVVYN---AADLKPIKAFTQ---------H 287 Query: 412 KELISGHGFAQ--NQLV---------IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVAS 460 ++ ++G F + NQL +W +A V L GH +L + V+ Sbjct: 288 RDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQERCVSV 347 Query: 461 AAADETLRLWRCFE 474 A D T R W+ E Sbjct: 348 GARDRTARYWKVPE 361 >3JRO-A nrPDB Length = 753 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/172 (25%), Positives = 64/172 (37%), Gaps = 24/172 (13%) Query: 236 KEGNYLAVGTSSAEVQLWDVQQQK--RLRNMTSHSARVGSLSWNSY----ILSSGSRSGH 289 K G LA + +V +W + + ++ HSA V S+ W + +L S G Sbjct: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 Query: 290 IHHHDVRVAEHHVAT---LSGHSQEVCGLRWAP-----DGRH--------LASGGNDNLV 333 + V E+ + + H+ V WAP DG H +GG DNLV Sbjct: 125 VSV--VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLV 182 Query: 334 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW 385 +W +V T H V+ VAW P + DR IW Sbjct: 183 KIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 >5OQL-d nrPDB Length = 446 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 29/130 (22%), Positives = 54/130 (41%), Gaps = 12/130 (9%) Query: 353 QHQGAVKAVAW----------CPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV 402 +H A +A+ W C Q G +DR I ++++ + + H Sbjct: 183 EHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHFAC 242 Query: 403 CSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL-KGHTSRVLSLTMSPDGATVASA 461 I+++P + + + + I+ K + KGH + V+ + SP G + S Sbjct: 243 NRIVFNP-MEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEELVSG 301 Query: 462 AADETLRLWR 471 + D T+RLWR Sbjct: 302 SYDRTIRLWR 311 >4G56-B nrPDB Length = 357 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 53/228 (23%), Positives = 86/228 (37%), Gaps = 50/228 (21%) Query: 229 ISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSG 288 ++ VAW+ E L V + S V+LW++ +++ SL N + Sbjct: 97 VTDVAWVSEKGIL-VASDSGAVELWEILEKE-------------SLLVNKF--------A 134 Query: 289 HIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPL 348 H D+ V TLS S DG SGG D V VW + L Sbjct: 135 KYEHDDI------VKTLSVFS----------DGTQAVSGGKDFSVKVWDLSQK----AVL 174 Query: 349 QTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVD---AHSQVCSI 405 +++ H V VA CP + + + G D I +W+ + +D + + S+ Sbjct: 175 KSYNAHSSEVNCVAACPGKDTIFLSCG--EDGRILLWDTRKPKPATRIDFCASDTIPTSV 232 Query: 406 LWSPHYKELIS-GHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMS 452 W P + + G LV K P A+ + + H+ + L S Sbjct: 233 TWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAV--HSQNITGLAYS 278 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 22/107 (20%), Positives = 50/107 (46%), Gaps = 3/107 (2%) Query: 172 PDRILDAPEIRNDYYLNLVDWSSGNVLAVALDN-SVYLWSASSGDILQLLQME--QPGEY 228 P+ L ++ + + V W S + VA D+ +V LW + L + + + + Sbjct: 82 PNESLCTAGVQTEAGVTDVAWVSEKGILVASDSGAVELWEILEKESLLVNKFAKYEHDDI 141 Query: 229 ISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS 275 + +++ +G G V++WD+ Q+ L++ +HS+ V ++ Sbjct: 142 VKTLSVFSDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVA 188 >5N4A-A nrPDB Length = 771 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 53/217 (24%), Positives = 88/217 (40%), Gaps = 23/217 (10%) Query: 267 HSARVGSLSWNSY-ILSSGSRSGHIHHHDVRVA-EHHVATLSGHSQEVCGLRWAP-DGRH 323 HS ++ WN + L + S IH ++ E V+TL + + + W P + Sbjct: 13 HSELTAAVGWNVWNELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTD---MHWYPVSSKK 69 Query: 324 LASGGNDNLVNVWPSAPGEGGWVPL-------QTFTQHQGAVKAVAWCPWQSNVLATGGG 376 +GG D V+ A +G L ++ H+GA ++ W + LAT G Sbjct: 70 TQAGGTD----VFAVACTDGSVKILSRTGRVEKSIEGHKGACISLRW-SYDGTALATAG- 123 Query: 377 TSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKV 436 D ++IW+ + A S V SI+W+ +L G + +VI + AK Sbjct: 124 -EDGSVKIWSRNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTG---SNVVIKSLSSNAKQ 179 Query: 437 AELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 K H VL + SP + + D ++W F Sbjct: 180 NAWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWDSF 216 >4U1E-I nrPDB Length = 347 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 26/105 (24%), Positives = 51/105 (48%), Gaps = 7/105 (6%) Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 L+GH + + +++ +G L S D+ +VW S GE L T H G + ++ Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGE----RLGTLDGHTGTIWSIDVD 61 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSP 409 + + G++D I++W+V +G C++ + V + +SP Sbjct: 62 CFTKYCVT---GSADYSIKLWDVSNGQCVATWKSPVPVKRVEFSP 103 Score = 32.3 bits (72), Expect = 0.48, Method: Compositional matrix adjust. Identities = 57/334 (17%), Positives = 117/334 (35%), Gaps = 80/334 (23%) Query: 190 VDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLA-----VG 244 VD + + + D S+ LW S+G + + P + V + GNY V Sbjct: 60 VDCFTKYCVTGSADYSIKLWDVSNGQCVATWKSPVP---VKRVEFSPCGNYFLAILDNVM 116 Query: 245 TSSAEVQLWDVQQQKRLRNMTSHS---------------ARVGSLSWNSYILSSGSRSGH 289 + + ++++++ +T S A V S + +G + G Sbjct: 117 KNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGK 176 Query: 290 IHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDN---LVNVWPSAPGEGGWV 346 I +DV +V ++ H + + ++++PD + + D LV+V Sbjct: 177 ISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDV----------S 226 Query: 347 PLQTFTQHQGAVKAVAWCPWQSNVLA-------TGGGTSDRHIRIWNVCSGACLSAVDAH 399 LQ +++ CP + V+ GGG + + + G Sbjct: 227 TLQVLKKYETD------CPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGK-------- 272 Query: 400 SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVA 459 + Y ++ ++ ++GH + ++ +SP G + A Sbjct: 273 ------FEARFYHKIFE-----------------EEIGRVQGHFGPLNTVAISPQGTSYA 309 Query: 460 SAAADETLRLWRCFELDPARRREREKASAAKSSL 493 S D +RL + + + EKA+ AK + Sbjct: 310 SGGEDGFIRLHHFEKSYFDFKYDVEKAAEAKEHM 343 >5MWJ-A nrPDB Length = 337 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 59/249 (23%), Positives = 105/249 (42%), Gaps = 16/249 (6%) Query: 227 EYISSVAWIKEGNYLAVGTSSAEVQLWDVQQ-QKRLRNMTSHSARVG---SLSWNSYILS 282 YI S + +G L VG ++ + +WD+ R++ + SA ++S +S + Sbjct: 98 NYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCF 157 Query: 283 SGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE 342 S G+I D+ + V GH+ + + DG L +GG DN V W E Sbjct: 158 SCCSDGNIAVWDLH-NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLR--E 214 Query: 343 GGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV 402 G + FT + ++ +CP LA G +S+ + + +V S V Sbjct: 215 GRQLQQHDFTSQ---IFSLGYCP-TGEWLAVGMESSN--VEVLHVNKPDKYQLHLHESCV 268 Query: 403 CSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAA 462 S+ ++ K +S N L W+ P A + + K +S VLS +S D + + + Sbjct: 269 LSLKFAYCGKWFVSTG--KDNLLNAWRTPYGASIFQSK-ESSSVLSCDISVDDKYIVTGS 325 Query: 463 ADETLRLWR 471 D+ ++ Sbjct: 326 GDKKATVYE 334 Score = 35.8 bits (81), Expect = 0.039, Method: Compositional matrix adjust. Identities = 43/190 (22%), Positives = 75/190 (39%), Gaps = 13/190 (6%) Query: 308 HSQEVCGLRWAPDGRHLASGGNDNLVNVWP-SAPGEGGWVPLQTFTQHQGAVKAVAWCPW 366 H + VC + + RH+ +GG V VW S PG V +++ P Sbjct: 50 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLP- 107 Query: 367 QSNVLATGGGTSDRHIRIWNVCSGA--CLSAVDAHSQVCSIL-WSPHYKELISGHGFAQN 423 L GG S + IW++ + + + + + C L SP K S + Sbjct: 108 DGCTLIVGGEAST--LSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSC--CSDG 163 Query: 424 QLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRRER 483 + +W V + +GHT + +S DG + + D T+R W +L R+ ++ Sbjct: 164 NIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSW---DLREGRQLQQ 220 Query: 484 EKASAAKSSL 493 ++ SL Sbjct: 221 HDFTSQIFSL 230 Score = 35.4 bits (80), Expect = 0.051, Method: Compositional matrix adjust. Identities = 33/147 (22%), Positives = 63/147 (42%), Gaps = 7/147 (4%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256 + D ++ +W + +++ Q G S + +G L G V+ WD++ Sbjct: 156 CFSCCSDGNIAVWDLHNQTLVRQFQGHTDGA--SCIDISNDGTKLWTGGLDNTVRSWDLR 213 Query: 257 QQKRLR--NMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCG 314 + ++L+ + TS +G + L+ G S ++ V + + L H V Sbjct: 214 EGRQLQQHDFTSQIFSLGYCPTGEW-LAVGMESSNVEVLHVNKPDKYQLHL--HESCVLS 270 Query: 315 LRWAPDGRHLASGGNDNLVNVWPSAPG 341 L++A G+ S G DNL+N W + G Sbjct: 271 LKFAYCGKWFVSTGKDNLLNAWRTPYG 297 >5WYJ-BE nrPDB Length = 939 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 31/111 (27%), Positives = 61/111 (54%), Gaps = 6/111 (5%) Query: 196 NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV 255 N L V ++V L++ +G ++ E P + I++ + +A+GT + EV ++++ Sbjct: 178 NKLTVVTKSNVLLFNVRTGKLV-FTSNEFPDQ-ITTAEPAPVLDIIALGTVTGEVIMFNM 235 Query: 256 QQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDV-RVAEHHV 302 ++ KR+R + +R+ SLS+ S LS G+ SG + +D+ R + HV Sbjct: 236 RKGKRIRTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDLDRRSRIHV 286 Score = 35.8 bits (81), Expect = 0.040, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 27/46 (58%) Query: 425 LVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 +V+ T V +L GH++R+ + SP+G + SA+ D T+R W Sbjct: 567 IVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTW 612 Score = 28.9 bits (63), Expect = 5.6, Method: Compositional matrix adjust. Identities = 13/45 (28%), Positives = 21/45 (46%) Query: 297 VAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPG 341 V + V L GHS + ++P+GR + S D+ + W G Sbjct: 573 VTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTG 617 >3JRP-A nrPDB Length = 379 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 40/152 (26%), Positives = 59/152 (38%), Gaps = 24/152 (15%) Query: 236 KEGNYLAVGTSSAEVQLWDVQQQK--RLRNMTSHSARVGSLSWNSY----ILSSGSRSGH 289 K G LA + +V +W + + ++ HSA V S+ W + +L S G Sbjct: 67 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 126 Query: 290 IHHHDVRVAEHHVAT---LSGHSQEVCGLRWAP-----DGRH--------LASGGNDNLV 333 + V E+ + + H+ V WAP DG H +GG DNLV Sbjct: 127 VSV--VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLV 184 Query: 334 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 365 +W +V T H V+ VAW P Sbjct: 185 KIWKYNSDAQTYVLESTLEGHSDWVRDVAWSP 216 >3ACP-A nrPDB Length = 417 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 28/98 (28%), Positives = 44/98 (44%), Gaps = 3/98 (3%) Query: 376 GTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA 434 GT++ I++ + AH S++ + + P + LIS QL IW + Sbjct: 112 GTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSS--QDMQLKIWSVKDGS 169 Query: 435 KVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 L GH + V + + G V SA+ D T+RLW C Sbjct: 170 NPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWEC 207 Score = 35.0 bits (79), Expect = 0.069, Method: Compositional matrix adjust. Identities = 36/147 (24%), Positives = 62/147 (42%), Gaps = 16/147 (10%) Query: 308 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQ 367 H E+ L++ P G L S D + +W G P +T H+ V +A Sbjct: 135 HVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSN---P-RTLIGHRATVTDIAIIDRG 190 Query: 368 SNVLATGGGTSDRHIRIWNVCSGACLSAVDA----HSQVCSI-LWSPHYKELISGHGFAQ 422 NVL+ + D IR+W +G + + H V SI L+ ++L H + Sbjct: 191 RNVLS---ASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTDRQL---HEIST 244 Query: 423 NQLVIWKYPTMAKVAELKGHTSRVLSL 449 ++ ++ T K + GH S V+++ Sbjct: 245 SKKNNLEFGTYGKYV-IAGHVSGVITV 270 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 28/108 (25%), Positives = 51/108 (47%), Gaps = 20/108 (18%) Query: 196 NVLAVALDNSVYLWSASSGDILQLL-QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWD 254 NVL+ +LD ++ LW +G + + E P + ++S+A L VGT QL + Sbjct: 192 NVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIA-------LFVGTDR---QLHE 241 Query: 255 VQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHV 302 + K+ ++ G ++ Y++ +G SG I H+V E + Sbjct: 242 ISTSKK------NNLEFG--TYGKYVI-AGHVSGVITVHNVFSKEQTI 280 >6CVZ-A nrPDB Length = 351 Score = 37.7 bits (86), Expect = 0.011, Method: Compositional matrix adjust. Identities = 30/136 (22%), Positives = 60/136 (44%), Gaps = 25/136 (18%) Query: 143 GYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYY----------LNLVDW 192 Y + L L + +P +S ++P ++L +++ Y L + Sbjct: 31 AYCDALSCLVISQPSPQAS-----FLPGFGVKMLSTANMKSSQYIPMHGKQIRGLAFSSY 85 Query: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAW-IKEGNYLAVGTSSAEVQ 251 G +L+ +LDN++ L S + ++Q +P + S W + E NY+ G ++ + Sbjct: 86 LRGLLLSASLDNTIKLTSLETNTVVQTYNAGRP---VWSCCWCLDEANYIYAGLANGSIL 142 Query: 252 LWDVQQQKRLRNMTSH 267 ++DV RN +SH Sbjct: 143 VYDV------RNTSSH 152 Score = 34.3 bits (77), Expect = 0.14, Method: Compositional matrix adjust. Identities = 22/54 (40%), Positives = 28/54 (51%), Gaps = 4/54 (7%) Query: 195 GNVLAVALD---NSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGT 245 GN+L D NS LW A+SG +LQ LQ +QP I + +YLA T Sbjct: 289 GNILVCTGDEAANSALLWDAASGSLLQDLQTDQPVLDICPFE-VNRNSYLATLT 341 >5WLC-LN nrPDB Length = 776 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 43/168 (25%), Positives = 61/168 (36%), Gaps = 19/168 (11%) Query: 314 GLRWA---PDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370 G+ W+ D + S G DN V G G + T Q A V W+ + Sbjct: 142 GVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEA--RVLTLAWKKDD 199 Query: 371 LATGGGTSDRHIRIW-------NVCSGACLSAVDAHSQVCSILWS----PHYKELISGHG 419 GG SD IRIW N+ VD + +++WS P ++ SG Sbjct: 200 FVIGG-CSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGD- 257 Query: 420 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETL 467 + + W + K H + VL LT D V SA D + Sbjct: 258 -STGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKI 304 Score = 33.5 bits (75), Expect = 0.24, Method: Compositional matrix adjust. Identities = 22/93 (23%), Positives = 46/93 (49%), Gaps = 11/93 (11%) Query: 203 DNSVYLWSASSGD-----ILQLLQMEQPGE---YISSVAWIKEGNYLAVGTSSAEVQLWD 254 D + +WSA D +L +++++ + + SV ++ + +A G S+ ++ WD Sbjct: 207 DGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWD 266 Query: 255 VQQQKRLRNMTSHSARVGSLSW---NSYILSSG 284 Q ++ +H A V L+ N+Y+ S+G Sbjct: 267 FQFATLNQSFKAHDADVLCLTTDTDNNYVFSAG 299 >4BZK-B nrPDB Length = 297 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 40/152 (26%), Positives = 59/152 (38%), Gaps = 24/152 (15%) Query: 236 KEGNYLAVGTSSAEVQLWDVQQQK--RLRNMTSHSARVGSLSWNSY----ILSSGSRSGH 289 K G LA + +V +W + + ++ HSA V S+ W + +L S G Sbjct: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 Query: 290 IHHHDVRVAEHHVAT---LSGHSQEVCGLRWAP-----DGRH--------LASGGNDNLV 333 + V E+ + + H+ V WAP DG H +GG DNLV Sbjct: 125 VSV--VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLV 182 Query: 334 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 365 +W +V T H V+ VAW P Sbjct: 183 KIWKYNSDAQTYVLESTLEGHSDWVRDVAWSP 214 >5OV3-A nrPDB Length = 381 Score = 37.4 bits (85), Expect = 0.016, Method: Compositional matrix adjust. Identities = 45/202 (22%), Positives = 78/202 (38%), Gaps = 25/202 (12%) Query: 280 ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSA 339 +L+ G G I D + +S H VC L W+ DG L S DN+V+ W Sbjct: 39 LLAVGCNDGRIVIWDF-LTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVL 97 Query: 340 PGEGGW-----VPLQTFTQHQGAVKAVAWCPWQSN-VLATGGGTSDRHIRIWNVCSGACL 393 G+ P+ H V CP +S V+ T + +H+ + Sbjct: 98 SGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDS--KHVVL--------- 146 Query: 394 SAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK-----GHTSRVLS 448 VD S + + E I G A+ ++++ K + VA + +T+ + S Sbjct: 147 -PVDDDSDLNVVASFDRRGEYIY-TGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKS 204 Query: 449 LTMSPDGATVASAAADETLRLW 470 + + G+ AD +R++ Sbjct: 205 IEFARKGSCFLINTADRIIRVY 226 >5WLC-LU nrPDB Length = 489 Score = 37.0 bits (84), Expect = 0.021, Method: Compositional matrix adjust. Identities = 26/152 (17%), Positives = 62/152 (40%), Gaps = 10/152 (6%) Query: 237 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHH 293 E + LA S + L+D++ + + + R ++ WN ++ + + + +++ Sbjct: 231 ETDILASTGSDNSIVLYDLRTNSPTQKIV-QTMRTNAICWNPMEAFNFVTANEDHNAYYY 289 Query: 294 DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ 353 D+R + H V + ++P G + +G D + ++ + G + Q Sbjct: 290 DMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQ 349 Query: 354 HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW 385 H VK + + G+ D ++R+W Sbjct: 350 HVFQVK------YSMDSKYIISGSDDGNVRLW 375 >6E29-D nrPDB Length = 345 Score = 37.0 bits (84), Expect = 0.022, Method: Compositional matrix adjust. Identities = 18/57 (31%), Positives = 32/57 (56%), Gaps = 3/57 (5%) Query: 230 SSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSS 283 + V + ++G++LA G V +WD++ R + HS + SLSW+ Y+LS+ Sbjct: 29 TCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRYLLSA 85 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 21/71 (29%), Positives = 36/71 (50%), Gaps = 3/71 (4%) Query: 195 GNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW 253 G+ LA +D +V +W + + + L+ I+S++W + G YL +V LW Sbjct: 37 GDFLASGRVDGTVVIWDLETMGVARKLRGHSKN--ITSLSWSRCGRYLLSACQGWKVILW 94 Query: 254 DVQQQKRLRNM 264 D+Q KR R + Sbjct: 95 DLQDGKRYREV 105 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 21/64 (32%), Positives = 29/64 (45%), Gaps = 2/64 (3%) Query: 419 GFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPA 478 G +VIW TM +L+GH+ + SL+ S G + SA + LW D Sbjct: 43 GRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRYLLSACQGWKVILWDL--QDGK 100 Query: 479 RRRE 482 R RE Sbjct: 101 RYRE 104 >2P9P-C nrPDB Length = 372 Score = 36.6 bits (83), Expect = 0.025, Method: Compositional matrix adjust. Identities = 28/104 (26%), Positives = 44/104 (42%), Gaps = 14/104 (13%) Query: 291 HHHDVRVAEH------HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG 344 ++H+V + E V L H+ +V G+ WAPD + + G D VW + G Sbjct: 28 NNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVTCGTDRNAYVW-TLKGR-T 85 Query: 345 WVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC 388 W P + A + V W P A G G+ R+ ++C Sbjct: 86 WKPTLVILRINRAARCVRWAP-NEKKFAVGSGS-----RVISIC 123 >4OWR-A nrPDB Length = 339 Score = 36.2 bits (82), Expect = 0.036, Method: Compositional matrix adjust. Identities = 21/71 (29%), Positives = 33/71 (46%), Gaps = 7/71 (9%) Query: 190 VDWSS--GNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247 V WS V + D + +W SS +Q+ Q + P + ++ WIK NY V T S Sbjct: 63 VCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAP---VKTIHWIKAPNYSCVMTGS 119 Query: 248 --AEVQLWDVQ 256 ++ WD + Sbjct: 120 WDKTLKFWDTR 130 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 14/39 (35%), Positives = 24/39 (61%), Gaps = 2/39 (5%) Query: 432 TMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 T+ K ++ HT VL + S DG+ V +A+ D+T ++W Sbjct: 48 TIPKAQQM--HTGPVLDVCWSDDGSKVFTASCDKTAKMW 84 >5WLC-SG nrPDB Length = 573 Score = 35.8 bits (81), Expect = 0.042, Method: Compositional matrix adjust. Identities = 26/136 (19%), Positives = 59/136 (43%), Gaps = 10/136 (7%) Query: 304 TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTF--TQHQGAVKAV 361 T GH E+ + +PDG+++ +GG D + VW + P++ +G V ++ Sbjct: 231 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTE----SLSPVKVIPTKDRRGEVLSL 286 Query: 362 AWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFA 421 A+ + A+ +D IR +++ + L + H + + + + ++ G Sbjct: 287 AFRKNSDQLYAS---CADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVT-VGAR 342 Query: 422 QNQLVIWKYPTMAKVA 437 ++WK P ++ Sbjct: 343 DRTAMLWKIPDETRLT 358 Score = 32.3 bits (72), Expect = 0.48, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 20/40 (50%) Query: 440 KGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPAR 479 +GH +L++ SPDG V + D L +W L P + Sbjct: 233 EGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVK 272 >5TF2-A nrPDB Length = 407 Score = 35.8 bits (81), Expect = 0.043, Method: Compositional matrix adjust. Identities = 13/32 (40%), Positives = 18/32 (56%) Query: 427 IWKYPTMAKVAELKGHTSRVLSLTMSPDGATV 458 +WK P++ KV E K H + L + PDG V Sbjct: 198 VWKVPSLEKVLEFKAHEGEIEDLALGPDGKLV 229 >5WLC-LV nrPDB Length = 707 Score = 35.8 bits (81), Expect = 0.050, Method: Compositional matrix adjust. Identities = 24/122 (19%), Positives = 57/122 (46%), Gaps = 10/122 (8%) Query: 204 NSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRL-- 261 N +Y + G L +++ G ++ V+ + LA GT + V+ WD + + R+ Sbjct: 160 NELYRLNLEKGRFLNPFKLDTEG--VNHVSINEVNGLLAAGTETNVVEFWDPRSRSRVSK 217 Query: 262 ----RNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGL 315 N+ + +V + S+ + + G+ +G+ + +D+R +E + G+ ++ + Sbjct: 218 LYLENNIDNRPFQVTTTSFRNDGLTFACGTSNGYSYIYDLRTSEPSIIKDQGYGFDIKKI 277 Query: 316 RW 317 W Sbjct: 278 IW 279 >5WBU-D nrPDB Length = 328 Score = 34.7 bits (78), Expect = 0.098, Method: Compositional matrix adjust. Identities = 48/250 (19%), Positives = 92/250 (36%), Gaps = 35/250 (14%) Query: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRV 297 LA V+ W R + ++V +L S I ++G + HI +D+ Sbjct: 17 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ--HIRMYDLNS 74 Query: 298 AEHH-VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG 356 + + + G ++ + + + DGR + +GG D +W + Q Q Sbjct: 75 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRN---LQCQRIFQVNA 131 Query: 357 AVKAVAWCPWQSNVLATGGGTSDRHIRIWNV---------------CSGACLSAVDAHSQ 401 + V P Q+ ++ G I IW++ + A + ++ Sbjct: 132 PINCVCLHPNQAELIV---GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 188 Query: 402 VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASA 461 + + + L G G QL+ ++ HT L SPD +A+ Sbjct: 189 AVNSTGNCYVWNLTGGIGDEVTQLI--------PKTKIPAHTRYALQCRFSPDSTLLATC 240 Query: 462 AADETLRLWR 471 +AD+T ++WR Sbjct: 241 SADQTCKIWR 250 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 25/102 (24%), Positives = 42/102 (41%), Gaps = 4/102 (3%) Query: 370 VLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIW 428 +LAT G D +R W SG C V SQV ++ +P + +I+ G+ ++ Sbjct: 16 ILATAG--YDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYDL 72 Query: 429 KYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 + G + S+ DG + + D T R+W Sbjct: 73 NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW 114 >3BG0-A nrPDB Length = 316 Score = 34.7 bits (78), Expect = 0.099, Method: Compositional matrix adjust. Identities = 43/182 (23%), Positives = 71/182 (39%), Gaps = 41/182 (22%) Query: 195 GNVLA-VALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWI--KEGNYLAVGTSSAEVQ 251 GN+LA + D V +W +G + + ++SV W G LA G+S + Sbjct: 71 GNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 Query: 252 L--------WDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVA 303 L W+V K++ N +H+ ++SW ++ G + H +++ Sbjct: 131 LLTYTGEGQWEV---KKINN--AHTIGCNAVSWAPAVVP-----GSLIDHPSGQKPNYI- 179 Query: 304 TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAW 363 + ASGG DNL+ +W +G W Q H V+ VAW Sbjct: 180 ------------------KRFASGGCDNLIKLWKEEE-DGQWKEEQKLEAHSDWVRDVAW 220 Query: 364 CP 365 P Sbjct: 221 AP 222 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 37/142 (26%), Positives = 59/142 (41%), Gaps = 20/142 (14%) Query: 238 GNYLAVGTSSAEVQLWDVQQ--QKRLRNMTSHSARVGSLSW----NSYILSSGSRSGHIH 291 G LA +S V+++DV+ Q + ++ H V ++W IL+S S + Sbjct: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCS-----Y 79 Query: 292 HHDVRVAEHHVATL------SGHSQEVCGLRWAPD--GRHLASGGNDNLVNVWPSAPGEG 343 V + T +GH V + WAP G LA G +D +++ + GEG Sbjct: 80 DRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL-LTYTGEG 138 Query: 344 GWVPLQTFTQHQGAVKAVAWCP 365 W + H AV+W P Sbjct: 139 QWEVKKINNAHTIGCNAVSWAP 160 Score = 29.6 bits (65), Expect = 3.1, Method: Compositional matrix adjust. Identities = 34/137 (24%), Positives = 58/137 (42%), Gaps = 16/137 (11%) Query: 239 NYL---AVGTSSAEVQLWDVQ---QQKRLRNMTSHSARVGSLSWNSYI------LSSGSR 286 NY+ A G ++LW + Q K + + +HS V ++W I ++S S+ Sbjct: 177 NYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQ 236 Query: 287 SGHIHHHDVRVAEHHVAT---LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEG 343 G + A + + L + V + W+ LA G DN V +W + +G Sbjct: 237 DGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESV-DG 295 Query: 344 GWVPLQTFTQHQGAVKA 360 WV + + QG+V A Sbjct: 296 QWVCISDVNKGQGSVSA 312 >4J0X-A nrPDB Length = 451 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 26/136 (19%), Positives = 59/136 (43%), Gaps = 10/136 (7%) Query: 304 TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTF--TQHQGAVKAV 361 T GH E+ + +PDG+++ +GG D + VW + P++ +G V ++ Sbjct: 109 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTE----SLSPVKVIPTKDRRGEVLSL 164 Query: 362 AWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFA 421 A+ + A+ +D IR +++ + L + H + + + + ++ G Sbjct: 165 AFRKNSDQLYAS---CADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVT-VGAR 220 Query: 422 QNQLVIWKYPTMAKVA 437 ++WK P ++ Sbjct: 221 DRTAMLWKIPDETRLT 236 Score = 32.7 bits (73), Expect = 0.42, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 20/40 (50%) Query: 440 KGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPAR 479 +GH +L++ SPDG V + D L +W L P + Sbjct: 111 EGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVK 150 >5CXB-B nrPDB Length = 369 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 14/44 (31%), Positives = 24/44 (54%), Gaps = 1/44 (2%) Query: 430 YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 +PT+ + +GH RV S+ + P G +A+ D T+R+W Sbjct: 9 FPTVQQTI-FRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELL 51 Score = 31.6 bits (70), Expect = 0.75, Method: Compositional matrix adjust. Identities = 22/80 (27%), Positives = 28/80 (35%), Gaps = 3/80 (3%) Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 GH V + P G LA+GG+D V VW G W AV V W Sbjct: 17 FRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVW---SVKLNGDEAVNTVRWR 73 Query: 365 PWQSNVLATGGGTSDRHIRI 384 P + + D + I Sbjct: 74 PTKDTFILAAAAGEDIFLMI 93 >6ELZ-p nrPDB Length = 460 Score = 33.9 bits (76), Expect = 0.15, Method: Compositional matrix adjust. Identities = 34/123 (27%), Positives = 52/123 (42%), Gaps = 23/123 (18%) Query: 231 SVAWIKEGNYLAVGTSSAEVQLWD--------VQQQKRLRNMTSHSARVGSLSW---NSY 279 S+A + N LA G+S+ + L D V QQ+ + H V SL N Y Sbjct: 334 SIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQ----LIGHKNFVSSLDTCPENEY 389 Query: 280 ILSSGSRSGHIHHHDVR-------VAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNL 332 IL SGS G + DVR + + G + +V ++WA + + S G D Sbjct: 390 ILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVKWA-EKVGIISAGQDKK 448 Query: 333 VNV 335 + + Sbjct: 449 IQI 451 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 39/168 (23%), Positives = 67/168 (39%), Gaps = 32/168 (19%) Query: 305 LSGHSQE--VCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 L+ S E V L +H+ SG D +V W + G V Q ++ H G ++AV Sbjct: 97 LNSFSNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLS----GNVQKQ-YSGHSGPIRAVK 151 Query: 363 WCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQ 422 + SN G +DR +R+W + +L S + Sbjct: 152 YI---SNTRLVSAG-NDRTLRLWKTKNDDL--------------------KLTSQQQAQE 187 Query: 423 NQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 + +A L+GH + V+S+ +S D + + SA+ D ++ W Sbjct: 188 DDDDEVNIEDGKTLAILEGHKAPVVSIDVS-DNSRILSASYDNSIGFW 234 >6CHG-D nrPDB Length = 439 Score = 33.9 bits (76), Expect = 0.16, Method: Compositional matrix adjust. Identities = 53/271 (19%), Positives = 89/271 (32%), Gaps = 102/271 (37%) Query: 238 GNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRV 297 G+YLAVG S+ + ++D+ K + + +HS Sbjct: 39 GDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSG---------------------------- 70 Query: 298 AEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGA 357 H++ V + W+ DGR+L S G D +W P + F Q++ Sbjct: 71 ---------AHTRSVQSVCWSNDGRYLWSSGRDWYAKLWDMTQ------PTKCFQQYK-- 113 Query: 358 VKAVAWCPWQSNVLATGGGTSDRHIRIWNVC--------SGACLSAVDAHSQV-CSILWS 408 G H+ WNVC + L+ D + C L Sbjct: 114 ---------------FDGPLWSCHVVRWNVCIVTVVEEPTAYVLTLTDRQNAFHCFPLLE 158 Query: 409 PHYKELISGHGFAQNQLVIWKYPTMAKVA----------------------------ELK 440 + ISGHG+ LV +PT+ + E K Sbjct: 159 Q--DQDISGHGYT---LVACPHPTIESIIITGTSKGWINAFQLDLESGFEDKIRCCYEEK 213 Query: 441 GHTSRVLSLTMSPDGATVASAAADETLRLWR 471 + + + +SP G +A +D T+R ++ Sbjct: 214 IANANIKQIIISPSGTRIAINGSDRTIRQYQ 244 >4PSX-B nrPDB Length = 401 Score = 33.9 bits (76), Expect = 0.17, Method: Compositional matrix adjust. Identities = 62/279 (22%), Positives = 110/279 (39%), Gaps = 49/279 (17%) Query: 205 SVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV----QQQKR 260 + +L+S S G + L+ + Y S + + +G L+ G+ V LW+V K Sbjct: 142 TTFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKGRLLS-GSDDHTVALWEVGSGGDPTKP 199 Query: 261 LRNMTS-HSARVGSLSWNSY---ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLR 316 +R HS + W+++ + + S + +DVR + T+ Q L Sbjct: 200 VRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKC-PQPFNTLA 258 Query: 317 WAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGG 375 ++ +L A+ G D+ V ++ + PL + H+ AV + + V+ + G Sbjct: 259 FSHHSSNLLAAAGMDSYVYLYDLRNMKE---PLHHMSGHEDAVNNLEFSTHVDGVVVSSG 315 Query: 376 GTSDRHIRIWNVCS-GACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA 434 SD + +W++ GA + DA V ELI H Sbjct: 316 --SDNRLMMWDLKQIGAEQTPDDAEDGV---------PELIMVHA--------------- 349 Query: 435 KVAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLWRC 472 GH S V ++P VASA + L++W+C Sbjct: 350 ------GHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 Score = 29.6 bits (65), Expect = 2.8, Method: Compositional matrix adjust. Identities = 37/164 (22%), Positives = 76/164 (46%), Gaps = 12/164 (7%) Query: 183 NDYYLNLVDWSSGNVLAVALDNSVYLWSA-SSGDILQLLQM--EQPGEYISSVAWIKEGN 239 N Y L+ G +L+ + D++V LW S GD + ++ + + I+ W N Sbjct: 162 NGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKW-HNFN 220 Query: 240 YLAVGTSSAE--VQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHD 294 GT S + +++ DV+ + +L++ +S +L++ +++ +D Sbjct: 221 KDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYD 280 Query: 295 VRVAEHHVATLSGHSQEVCGLRWAP--DGRHLASGGNDNLVNVW 336 +R + + +SGH V L ++ DG + S G+DN + +W Sbjct: 281 LRNMKEPLHHMSGHEDAVNNLEFSTHVDGV-VVSSGSDNRLMMW 323 >5YZG-2 nrPDB Length = 646 Score = 33.5 bits (75), Expect = 0.24, Method: Compositional matrix adjust. Identities = 21/85 (24%), Positives = 37/85 (43%), Gaps = 13/85 (15%) Query: 400 SQVCSILWSPHYKELISG-------------HGFAQNQLVIWKYPTMAKVAELKGHTSRV 446 S + I +P YK ++S H + + V W+Y T + E + Sbjct: 224 SPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYP 283 Query: 447 LSLTMSPDGATVASAAADETLRLWR 471 S+ SPDG +A+ +D +R++R Sbjct: 284 TSVCFSPDGKKIATIGSDRKVRIFR 308 >3ODT-A nrPDB Length = 313 Score = 32.7 bits (73), Expect = 0.38, Method: Compositional matrix adjust. Identities = 48/231 (20%), Positives = 86/231 (37%), Gaps = 51/231 (22%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQ---LW 253 V +V+ D +V LWS + ++ Q +++SV + E L G + L+ Sbjct: 32 VASVSRDGTVRLWSKDDQWLGTVVYTGQG--FLNSVCYDSEKELLLFGGKDTMINGVPLF 89 Query: 254 DVQQQKRLRNMTSHSARVGSLSWNSYILSSGS--------RSGHIHHH---------DVR 296 + L + H V SLS+ ++ SGS + G + ++ D + Sbjct: 90 ATSGEDPLYTLIGHQGNVCSLSFQDGVVISGSWDKTAKVWKEGSLVYNLQAHNASVWDAK 149 Query: 297 VA---------------------EHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNV 335 V + + T SG +V D H S ND L+ + Sbjct: 150 VVSFSENKFLTASADKTIKLWQNDKVIKTFSGIHNDVVRHLAVVDDGHFISCSNDGLIKL 209 Query: 336 WPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWN 386 G+ L+T+ H+ V + P ++++ G DR +RIW+ Sbjct: 210 VDMHTGD----VLRTYEGHESFVYCIKLLP-NGDIVSCG---EDRTVRIWS 252 >5CXC-A nrPDB Length = 510 Score = 32.7 bits (73), Expect = 0.38, Method: Compositional matrix adjust. Identities = 17/48 (35%), Positives = 29/48 (60%), Gaps = 1/48 (2%) Query: 436 VAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLWRCFELDPARRRE 482 V L+GH ++V+SL+ SP+ ++ S + D T R+W + PA + E Sbjct: 396 VMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEE 443 >6BX3-B nrPDB Length = 412 Score = 32.7 bits (73), Expect = 0.41, Method: Compositional matrix adjust. Identities = 31/135 (22%), Positives = 56/135 (41%), Gaps = 9/135 (6%) Query: 302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP-SAPGEGGWVPLQTFTQHQGAVKA 360 + +L S + L + +G LA +D + + S E V L ++Q + Sbjct: 206 IHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINK 265 Query: 361 VAW-CPWQSN-----VLATGGGTSDRHIRIWNVCSGACLSAVD-AHSQVCSILWSPHYKE 413 + W C SN ++A+ G+S + IW SG + ++ A ++ I W Y Sbjct: 266 LQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWD-FYSM 324 Query: 414 LISGHGFAQNQLVIW 428 I +GF + +W Sbjct: 325 SIVSNGFESGNVYVW 339 Score = 29.3 bits (64), Expect = 4.7, Method: Compositional matrix adjust. Identities = 16/56 (28%), Positives = 27/56 (48%), Gaps = 4/56 (7%) Query: 419 GFAQNQLVIWKYPTMAKVA----ELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 G A LVI+ T + L H + S+ SPDG + +++ D +++LW Sbjct: 43 GCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLW 98 Score = 28.5 bits (62), Expect = 6.7, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 20/40 (50%), Gaps = 4/40 (10%) Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW----PSAP 340 L H + + + W+PDGR L + D + +W PS P Sbjct: 67 LGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKP 106 >5MC6-j nrPDB Length = 397 Score = 32.0 bits (71), Expect = 0.64, Method: Compositional matrix adjust. Identities = 23/76 (30%), Positives = 36/76 (47%), Gaps = 8/76 (10%) Query: 395 AVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPD 454 A D++S C L+ + E I L + + + A + E H+S V+SL+ + Sbjct: 251 AHDSNSFGCITLYETEFGERI-------GSLSVPTHSSQASLGEF-AHSSWVMSLSFNDS 302 Query: 455 GATVASAAADETLRLW 470 G T+ SA D LR W Sbjct: 303 GETLCSAGWDGKLRFW 318 >5WLC-LW nrPDB Length = 554 Score = 31.6 bits (70), Expect = 0.74, Method: Compositional matrix adjust. Identities = 23/89 (25%), Positives = 48/89 (53%), Gaps = 4/89 (4%) Query: 203 DNSVYLWSASSGD-ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRL 261 + +V LWS S + +++LL P ++S+A + G Y+A + +++WD++ K+L Sbjct: 253 NGTVSLWSPSMPEPLVKLLSARGP---VNSIAIDRSGYYMATTGADRSMKIWDIRNFKQL 309 Query: 262 RNMTSHSARVGSLSWNSYILSSGSRSGHI 290 ++ S ++S + L + SR H+ Sbjct: 310 HSVESLPTPGTNVSISDTGLLALSRGPHV 338 >2QTY-A nrPDB Length = 347 Score = 31.6 bits (70), Expect = 0.78, Method: Compositional matrix adjust. Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 5/71 (7%) Query: 244 GTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVA 303 G S A + DVQ+ RL +H++ SL +N IL + + H+ V +EH + Sbjct: 143 GISLAYSSVQDVQKFARLSAQLTHAS---SLGYNGAILQA--LAVHLALQGVSSSEHFLE 197 Query: 304 TLSGHSQEVCG 314 L GH +E+ G Sbjct: 198 QLLGHMEELEG 208 >3F3P-A nrPDB Length = 351 Score = 31.6 bits (70), Expect = 0.84, Method: Compositional matrix adjust. Identities = 18/81 (22%), Positives = 38/81 (46%), Gaps = 3/81 (3%) Query: 306 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC- 364 SGH V + + GRH+A+ +D + V+ W ++ H ++ A+ W Sbjct: 8 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 67 Query: 365 PWQSNVLATGGGTSDRHIRIW 385 P ++A+ + D+ +++W Sbjct: 68 PEYGRIIAS--ASYDKTVKLW 86 >3DWL-C nrPDB Length = 377 Score = 31.6 bits (70), Expect = 0.92, Method: Compositional matrix adjust. Identities = 23/88 (26%), Positives = 33/88 (37%), Gaps = 7/88 (7%) Query: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 360 H T S H + V + WAP + + D V+ P +G W + A Sbjct: 47 HARTFSDHDKIVTCVDWAPKSNRIVTCSQDRNAYVYEKRP-DGTWKQTLVLLRLNRAATF 105 Query: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVC 388 V W P + A G G R+ +VC Sbjct: 106 VRWSP-NEDKFAVGSGA-----RVISVC 127 >5A9Q-7 nrPDB Length = 360 Score = 31.2 bits (69), Expect = 0.99, Method: Compositional matrix adjust. Identities = 20/68 (29%), Positives = 33/68 (48%), Gaps = 8/68 (11%) Query: 409 PHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLR 468 P KEL S G + ++ I VA+ H S+V ++ + G +AS+ D +R Sbjct: 252 PVRKELTSSGGPTKFEIHI--------VAQFDNHNSQVWRVSWNITGTVLASSGDDGCVR 303 Query: 469 LWRCFELD 476 LW+ +D Sbjct: 304 LWKANYMD 311 Score = 29.6 bits (65), Expect = 3.6, Method: Compositional matrix adjust. Identities = 14/37 (37%), Positives = 19/37 (51%) Query: 300 HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 336 H VA H+ +V + W G LAS G+D V +W Sbjct: 269 HIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305 >5FA5-B nrPDB Length = 367 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 18/82 (21%), Positives = 40/82 (48%), Gaps = 4/82 (4%) Query: 197 VLAVALDNSVYLWSASSGDIL---QLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW 253 +L + +V LW + L + + E + +S+V+ + G G+ +++W Sbjct: 119 ILVASDSGAVELWELDENETLIVSKFCKYEH-DDIVSTVSVLSSGTQAVSGSKDICIKVW 177 Query: 254 DVQQQKRLRNMTSHSARVGSLS 275 D+ QQ L + +H+A+V ++ Sbjct: 178 DLAQQVVLSSYRAHAAQVTCVA 199 Score = 28.5 bits (62), Expect = 7.7, Method: Compositional matrix adjust. Identities = 19/65 (29%), Positives = 36/65 (55%), Gaps = 6/65 (9%) Query: 369 NVLATG----GGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQN 423 +VL++G G+ D I++W++ LS+ AH +QV + SPH K+ + N Sbjct: 157 SVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPH-KDSVFLSCSEDN 215 Query: 424 QLVIW 428 ++++W Sbjct: 216 RILLW 220 >1PI6-A nrPDB Length = 615 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 24/121 (19%), Positives = 54/121 (44%), Gaps = 9/121 (7%) Query: 203 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE----VQLWDVQQQ 258 D+ + + + +GDI++ +++ PG +S NY+AVG +L D++ Sbjct: 426 DDDLLILQSFTGDIIKSVRLNSPGSAVS-----LSQNYVAVGLEEGNTIQVFKLSDLEVS 480 Query: 259 KRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWA 318 L+ S+S + +++G G I +D++ E + + + ++ + W Sbjct: 481 FDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFRTSKINAISWK 540 Query: 319 P 319 P Sbjct: 541 P 541 Score = 29.6 bits (65), Expect = 2.8, Method: Compositional matrix adjust. Identities = 21/80 (26%), Positives = 38/80 (47%), Gaps = 5/80 (6%) Query: 315 LRWAPD-GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLAT 373 + ++PD G + + G+D ++ + GE QG + A++W Q AT Sbjct: 212 VEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQK--FAT 269 Query: 374 GGGTSDRHIRIWNVCSGACL 393 G +D IR+W+V + C+ Sbjct: 270 VG--ADATIRVWDVTTSKCV 287 >5WLC-LH nrPDB Length = 896 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 25/92 (27%), Positives = 43/92 (46%), Gaps = 14/92 (15%) Query: 268 SARVGSLSWNSYILSS------------GSRSGHIHHHDVRVAEHHVATLSGHSQEVCGL 315 S++ SLS+N+ +SS G SG I V +A+ + L H V L Sbjct: 246 SSQTQSLSYNTRYVSSMAIDNMGQQLAVGFASGVISI--VSLADLQIRLLKWHIDSVLSL 303 Query: 316 RWAPDGRHLASGGNDNLVNVWPSAPGEGGWVP 347 ++ DG +L SGG + ++++W ++P Sbjct: 304 SFSHDGSYLLSGGWEKVMSLWQLETNSQQFLP 335 Score = 29.3 bits (64), Expect = 4.3, Method: Compositional matrix adjust. Identities = 17/54 (31%), Positives = 28/54 (51%), Gaps = 1/54 (1%) Query: 419 GFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 GFA + I + ++ LK H VLSL+ S DG+ + S ++ + LW+ Sbjct: 274 GFASGVISIVSLADL-QIRLLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLWQL 326 >5M89-A nrPDB Length = 329 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 28/101 (27%), Positives = 40/101 (39%), Gaps = 4/101 (3%) Query: 242 AVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHH 301 AVG ++ ++ V K R + V + W + G+ G + +D A Sbjct: 67 AVGGLDGKLDIYSVVANKVERTL-DIGEPVTATEWTGTKVVIGTAKGWVKVYD---AGRE 122 Query: 302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE 342 AT H+ V GL P GR LAS G D + GE Sbjct: 123 SATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGE 163 Score = 29.3 bits (64), Expect = 4.2, Method: Compositional matrix adjust. Identities = 27/141 (19%), Positives = 61/141 (43%), Gaps = 6/141 (4%) Query: 195 GNVLA-VALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW 253 G +LA V +D S + +G+ + + +++ A+ +GN A GT + + ++ Sbjct: 142 GRILASVGVDKSFVFYDLETGERVARGYADAA---LTTCAFHPDGNLFAAGTQTGHILVF 198 Query: 254 DVQQQKRLRNM-TSHSARVGSLSWNSY-ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQE 311 ++ + + + S N + ++G + + D+R + A + E Sbjct: 199 HTTTLEQAESFPLGTPIQALAFSENGFWFAATGKGTSSVTIFDLRKSGAAAAVKELQTGE 258 Query: 312 VCGLRWAPDGRHLASGGNDNL 332 V + W G++LA+GG + Sbjct: 259 VLSISWDYTGQYLATGGGTGV 279 >6EM1-m nrPDB Length = 807 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 11/33 (33%), Positives = 20/33 (60%) Query: 441 GHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 GH +V +L++ P G +A+ + D T+R+W Sbjct: 435 GHKGKVRTLSIDPSGLWLATGSDDGTVRVWEIL 467 >6CB1-s nrPDB Length = 569 Score = 30.0 bits (66), Expect = 2.5, Method: Compositional matrix adjust. Identities = 11/33 (33%), Positives = 20/33 (60%) Query: 441 GHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 GH +V +L++ P G +A+ + D T+R+W Sbjct: 197 GHKGKVRTLSIDPSGLWLATGSDDGTVRVWEIL 229 >6C0F-s nrPDB Length = 807 Score = 30.0 bits (66), Expect = 2.6, Method: Compositional matrix adjust. Identities = 11/33 (33%), Positives = 20/33 (60%) Query: 441 GHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 GH +V +L++ P G +A+ + D T+R+W Sbjct: 435 GHKGKVRTLSIDPSGLWLATGSDDGTVRVWEIL 467 >4Y07-A nrPDB Length = 374 Score = 30.0 bits (66), Expect = 2.7, Method: Compositional matrix adjust. Identities = 14/46 (30%), Positives = 25/46 (54%), Gaps = 5/46 (10%) Query: 227 EYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVG 272 E+ +S+ WIKE N G ++L+ +Q + L +T+H + G Sbjct: 159 EFYNSIVWIKENNLEECG-----LELYFIQDMEILGKVTTHELKEG 199 >5A9Q-2 nrPDB Length = 326 Score = 29.6 bits (65), Expect = 3.0, Method: Compositional matrix adjust. Identities = 13/33 (39%), Positives = 19/33 (57%), Gaps = 1/33 (3%) Query: 439 LKGHTSRVLSLTMSP-DGATVASAAADETLRLW 470 L+GHT + L P +G +AS + D T R+W Sbjct: 120 LEGHTDFINGLVFDPKEGQEIASVSDDHTCRIW 152 >1AKL-A nrPDB Length = 470 Score = 29.6 bits (65), Expect = 3.4, Method: Compositional matrix adjust. Identities = 15/58 (25%), Positives = 28/58 (48%) Query: 394 SAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTM 451 SA + S++ +W + + GF+QNQ + ++ V LKG+ S +T+ Sbjct: 271 SATSSSSKLVFSVWDAGGNDTLDFSGFSQNQKINLNEKALSDVGGLKGNVSIAAGVTV 328 >5TJ8-A nrPDB Length = 447 Score = 29.6 bits (65), Expect = 3.4, Method: Compositional matrix adjust. Identities = 15/49 (30%), Positives = 26/49 (53%), Gaps = 5/49 (10%) Query: 227 EYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS 275 E+ +S+ WIKE N G ++L+ +Q + L +T+H + G S Sbjct: 232 EFYNSIVWIKENNLEECG-----LELYFIQDMEILGKVTTHELKEGGES 275 >3JZG-A nrPDB Length = 402 Score = 29.3 bits (64), Expect = 3.8, Method: Compositional matrix adjust. Identities = 17/50 (34%), Positives = 22/50 (44%), Gaps = 3/50 (6%) Query: 425 LVIWKYPTMAKVAEL---KGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 L +W T VA +GH VLS G + S D +L+LWR Sbjct: 176 LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 225 >3JB9-S nrPDB Length = 488 Score = 28.9 bits (63), Expect = 5.3, Method: Compositional matrix adjust. Identities = 26/109 (23%), Positives = 50/109 (45%), Gaps = 8/109 (7%) Query: 194 SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW 253 SG L A + Y++S S Q+ + ++I+S+A +GN G + E++ + Sbjct: 306 SGEYLLAASNEKCYIFSLKS----QVYNI-TVAQHITSLAVHPDGNLFVAGLENGELRFF 360 Query: 254 DVQQQKRLRNMTSHSARVGSLSW--NSY-ILSSGSRSGHIHHHDVRVAE 299 + L HS+ V +L + N Y ++ + + I D+R +E Sbjct: 361 ETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSE 409 >6O85-E nrPDB Length = 523 Score = 28.5 bits (62), Expect = 6.2, Method: Compositional matrix adjust. Identities = 36/156 (23%), Positives = 63/156 (40%), Gaps = 22/156 (14%) Query: 27 RWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTP---GKSSSKVQTTPSKPGGDRYIPHR 83 R +R+AK+ A A ++ A + G P +P G++ S V+ P P D + R Sbjct: 101 RAERRAKQEAERA---LKQARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRR 157 Query: 84 SAAQMEVASFLLSKENQPENSQTPTKKEHQKAWAL--NLNGFDVEEAKILRLSGKPQNAP 141 +PE Q PT+K++ +L +L + + + + P + Sbjct: 158 LV-------------KKPERQQVPTRKDYGSKVSLFSHLPQYS-RQNSLTQFMSIPSSVI 203 Query: 142 EGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILD 177 RL + YSQ GS+ + + +L I D Sbjct: 204 HPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQD 239 >3W15-A nrPDB Length = 368 Score = 28.1 bits (61), Expect = 9.1, Method: Compositional matrix adjust. Identities = 20/69 (28%), Positives = 31/69 (44%), Gaps = 9/69 (13%) Query: 324 LASGGNDNLVNVWP-----SAPGE--GGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGG 376 +A+GG DN + +W PG+ + H A++ V W P SN+L + Sbjct: 238 VATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMS--A 295 Query: 377 TSDRHIRIW 385 + D RIW Sbjct: 296 SYDMTCRIW 304 >5LTD-A nrPDB Length = 525 Score = 28.1 bits (61), Expect = 9.9, Method: Compositional matrix adjust. Identities = 12/37 (32%), Positives = 23/37 (62%) Query: 442 HTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPA 478 + +++ SL SPD V +++A ET+ ++R E + A Sbjct: 266 YPTKIYSLAFSPDNRFVIASSATETVHIFRLGEEEAA 302 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5G04-R nrPDB 699 0.0 4GGA-A nrPDB 530 e-151 5LCW-Q nrPDB 466 e-132 4N14-A nrPDB 399 e-111 5A31-R nrPDB 369 e-102 5L9T-R nrPDB 357 8e-99 4AEZ-A nrPDB 354 7e-98 4BH6-A nrPDB 316 2e-86 5NNZ-B nrPDB 280 7e-76 5MZH-A nrPDB 276 1e-74 1VYH-C nrPDB 275 2e-74 5M25-A nrPDB 253 1e-67 3DM0-A nrPDB 252 2e-67 2H9P-A nrPDB 248 5e-66 6G51-g nrPDB 245 5e-65 4V6W-Ag nrPDB 240 1e-63 5FL8-q nrPDB 239 2e-63 6F3T-A nrPDB 238 4e-63 6EOJ-D nrPDB 233 1e-61 5UZ7-B nrPDB 230 1e-60 6N9G-C nrPDB 227 1e-59 6QX9-4B nrPDB 222 3e-58 4V8M-A7 nrPDB 221 6e-58 6MZM-G nrPDB 221 7e-58 6HQA-B nrPDB 220 2e-57 5OPT-p nrPDB 217 7e-57 5OQL-J nrPDB 217 1e-56 5WYK-BB nrPDB 217 1e-56 6QX9-5O nrPDB 215 5e-56 3MKQ-A nrPDB 211 6e-55 5NZU-C nrPDB 211 8e-55 6J6H-n nrPDB 208 4e-54 2YNP-A nrPDB 207 9e-54 6HHQ-h nrPDB 200 9e-52 3JAP-g nrPDB 200 1e-51 5WLC-LO nrPDB 198 7e-51 4A11-B nrPDB 196 1e-50 5I2T-A nrPDB 196 2e-50 4V7E-Bg nrPDB 194 6e-50 6ID0-T nrPDB 194 7e-50 5WYJ-BC nrPDB 193 2e-49 5Y88-O nrPDB 191 7e-49 6QDV-o nrPDB 181 5e-46 3FM0-A nrPDB 180 9e-46 5YZG-W nrPDB 180 1e-45 5Z56-q nrPDB 176 2e-44 6GMH-W nrPDB 174 7e-44 4LG8-A nrPDB 173 1e-43 3JB9-L nrPDB 173 2e-43 4YCZ-A nrPDB 173 2e-43 4BTS-AR nrPDB 173 2e-43 5GAN-H nrPDB 172 3e-43 5Y1U-A nrPDB 172 3e-43 3C9C-A nrPDB 171 5e-43 2HES-X nrPDB 171 5e-43 5OQL-L nrPDB 169 2e-42 6Q8F-A nrPDB 169 3e-42 5FVM-C nrPDB 168 7e-42 3CFV-B nrPDB 167 1e-41 6EMK-B nrPDB 165 5e-41 3JB9-g nrPDB 160 1e-39 5K1B-B nrPDB 159 2e-39 4J0W-A nrPDB 157 1e-38 5WJC-A nrPDB 156 3e-38 2PM9-A nrPDB 156 3e-38 4L9O-A nrPDB 155 4e-38 5XYI-g nrPDB 154 6e-38 6CHG-A nrPDB 153 2e-37 4XYI-A nrPDB 142 4e-34 6BX3-A nrPDB 141 9e-34 1NR0-A nrPDB 138 7e-33 4XFV-A nrPDB 122 2e-28 5BJS-A nrPDB 116 2e-26 2AQ5-A nrPDB 111 8e-25 5K0Y-T nrPDB 108 7e-24 5OQL-X nrPDB 106 3e-23 5K19-A nrPDB 67 2e-11 Sequences not found previously or not previously below threshold: 3JRO-A nrPDB 149 2e-36 3JRP-A nrPDB 141 5e-34 4BZK-B nrPDB 139 3e-33 6ELZ-p nrPDB 138 5e-33 3ODT-A nrPDB 131 5e-31 3BG0-A nrPDB 131 8e-31 5OQL-d nrPDB 126 3e-29 5WLC-LJ nrPDB 124 9e-29 5WBU-D nrPDB 122 3e-28 4PSX-B nrPDB 119 3e-27 5MWJ-A nrPDB 117 1e-26 5CXC-A nrPDB 116 2e-26 5WLC-LU nrPDB 114 8e-26 4U1E-I nrPDB 107 8e-24 5A9Q-7 nrPDB 107 9e-24 5WYJ-BE nrPDB 105 4e-23 4E5Z-B nrPDB 101 7e-22 5M89-A nrPDB 100 1e-21 5N4A-A nrPDB 100 2e-21 4J0X-A nrPDB 100 2e-21 5WLC-SG nrPDB 99 3e-21 4G56-B nrPDB 99 4e-21 3F3P-A nrPDB 99 5e-21 3JZG-A nrPDB 97 1e-20 3W15-A nrPDB 96 4e-20 5FA5-B nrPDB 95 6e-20 3EI3-B nrPDB 95 8e-20 4OWR-A nrPDB 94 9e-20 3I2N-A nrPDB 92 5e-19 5WLC-LN nrPDB 91 7e-19 5OV3-A nrPDB 88 8e-18 6EM1-m nrPDB 86 4e-17 6CB1-s nrPDB 86 5e-17 6C0F-s nrPDB 85 7e-17 6E29-D nrPDB 84 1e-16 5YZG-2 nrPDB 83 3e-16 6F1U-h nrPDB 81 8e-16 1PI6-A nrPDB 81 2e-15 5CXB-B nrPDB 81 2e-15 5A9Q-2 nrPDB 80 3e-15 6BX3-B nrPDB 78 1e-14 5A9Q-0 nrPDB 78 1e-14 3ACP-A nrPDB 77 2e-14 2P9P-C nrPDB 76 5e-14 3JB9-S nrPDB 74 1e-13 5MC6-j nrPDB 72 6e-13 6CHG-D nrPDB 71 1e-12 5AMS-A nrPDB 65 7e-11 3DWL-C nrPDB 63 2e-10 5TF2-A nrPDB 62 4e-10 5WLC-LW nrPDB 59 6e-09 6CVZ-A nrPDB 57 1e-08 5LTD-A nrPDB 57 2e-08 3DW8-B nrPDB 57 2e-08 5AJA-A nrPDB 57 2e-08 6IYY-A nrPDB 56 3e-08 5K1H-B nrPDB 52 5e-07 5WLC-LH nrPDB 51 1e-06 2VDU-B nrPDB 50 2e-06 5WLC-LS nrPDB 48 7e-06 6N8P-A nrPDB 47 2e-05 4FHN-A nrPDB 46 5e-05 3WJ9-A nrPDB 44 1e-04 5WLC-LL nrPDB 43 3e-04 5WLC-LV nrPDB 43 3e-04 4AV8-A nrPDB 43 3e-04 2I3T-A nrPDB 42 5e-04 4YHC-A nrPDB 41 0.002 5BPT-A nrPDB 40 0.002 5BPW-A nrPDB 40 0.002 2EEP-A nrPDB 39 0.007 5GRS-A nrPDB 39 0.007 4R40-A nrPDB 38 0.010 1C5K-A nrPDB 37 0.014 3AZQ-A nrPDB 37 0.019 4MHC-A nrPDB 36 0.036 5CWW-B nrPDB 33 0.24 4IMM-A nrPDB 33 0.29 2XE4-A nrPDB 33 0.29 5SUM-A nrPDB 32 0.54 5JRK-A nrPDB 31 1.0 5HAX-A nrPDB 31 1.1 4Q1V-A nrPDB 31 1.2 1L9X-A nrPDB 31 1.3 1FLG-A nrPDB 30 2.6 5ODS-A nrPDB 29 4.7 4G55-A nrPDB 29 4.7 1BPO-A nrPDB 29 4.7 1K3I-A nrPDB 29 7.2 >5G04-R nrPDB Length = 499 Score = 699 bits (1803), Expect = 0.0, Method: Composition-based stats. Identities = 499/499 (100%), Positives = 499/499 (100%) Query: 1 MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTP 60 MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTP Sbjct: 1 MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTP 60 Query: 61 GKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNL 120 GKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNL Sbjct: 61 GKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNL 120 Query: 121 NGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPE 180 NGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPE Sbjct: 121 NGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPE 180 Query: 181 IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY 240 IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY Sbjct: 181 IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY 240 Query: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH 300 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH Sbjct: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH 300 Query: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 360 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA Sbjct: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 360 Query: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGF 420 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGF Sbjct: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGF 420 Query: 421 AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR Sbjct: 421 AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 Query: 481 REREKASAAKSSLIHQGIR 499 REREKASAAKSSLIHQGIR Sbjct: 481 REREKASAAKSSLIHQGIR 499 >4GGA-A nrPDB Length = 420 Score = 530 bits (1364), Expect = e-151, Method: Composition-based stats. Identities = 419/419 (100%), Positives = 419/419 (100%) Query: 81 PHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNA 140 PHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNA Sbjct: 2 PHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNA 61 Query: 141 PEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAV 200 PEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAV Sbjct: 62 PEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAV 121 Query: 201 ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKR 260 ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKR Sbjct: 122 ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKR 181 Query: 261 LRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD 320 LRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD Sbjct: 182 LRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD 241 Query: 321 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDR 380 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDR Sbjct: 242 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDR 301 Query: 381 HIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK 440 HIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK Sbjct: 302 HIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK 361 Query: 441 GHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR 499 GHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR Sbjct: 362 GHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR 420 >5LCW-Q nrPDB Length = 374 Score = 466 bits (1200), Expect = e-132, Method: Composition-based stats. Identities = 374/374 (100%), Positives = 374/374 (100%) Query: 126 EEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDY 185 EEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDY Sbjct: 1 EEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDY 60 Query: 186 YLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGT 245 YLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGT Sbjct: 61 YLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGT 120 Query: 246 SSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATL 305 SSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATL Sbjct: 121 SSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATL 180 Query: 306 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 365 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP Sbjct: 181 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 240 Query: 366 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQL 425 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQL Sbjct: 241 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQL 300 Query: 426 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREK 485 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREK Sbjct: 301 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREK 360 Query: 486 ASAAKSSLIHQGIR 499 ASAAKSSLIHQGIR Sbjct: 361 ASAAKSSLIHQGIR 374 >4N14-A nrPDB Length = 314 Score = 399 bits (1025), Expect = e-111, Method: Composition-based stats. Identities = 313/314 (99%), Positives = 313/314 (99%) Query: 164 TCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQME 223 CRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQME Sbjct: 1 GCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQME 60 Query: 224 QPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSS 283 QPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSS Sbjct: 61 QPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSS 120 Query: 284 GSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEG 343 GSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEG Sbjct: 121 GSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEG 180 Query: 344 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVC 403 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVC Sbjct: 181 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVC 240 Query: 404 SILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAA 463 SILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAA Sbjct: 241 SILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAA 300 Query: 464 DETLRLWRCFELDP 477 DETLRLWRCFELDP Sbjct: 301 DETLRLWRCFELDP 314 >5A31-R nrPDB Length = 386 Score = 369 bits (948), Expect = e-102, Method: Composition-based stats. Identities = 161/403 (39%), Positives = 239/403 (59%), Gaps = 31/403 (7%) Query: 76 GDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSG 135 GDR+IP R+ A V +F EN S K E A G + + + S Sbjct: 4 GDRFIPSRAGANWSV-NFHRINENGLAYSAL-LKNELLGA------GIEKVQKGLFTYSL 55 Query: 136 KPQNAPEGYQNRLKVLYSQKATPGSSRK--TCRYIPSLPDRILDAPEIRNDYYLNLVDWS 193 P YS S+K R I +P R+LDAP + +D+Y +L+DWS Sbjct: 56 SP--------------YSLSPVSNKSQKLLRSRQIAKVPYRVLDAPSLADDFYYSLIDWS 101 Query: 194 SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW 253 S +VLAVAL S++L ++GD++ L E +S++WI G++LAVG ++ V+++ Sbjct: 102 STDVLAVALGKSIFLTDNNTGDVVHLCDTE---NEYTSLSWIGAGSHLAVGQANGLVEIY 158 Query: 254 DVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVC 313 DV ++K +R ++ H RV LSWN+++L+SGSR I H DVR+ + T+ H+QEVC Sbjct: 159 DVMKRKCIRTLSGHIDRVACLSWNNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVC 218 Query: 314 GLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLAT 373 GL+W LASGGNDN+V+V+ P+ TF +H+ AVKA+AW P + VLAT Sbjct: 219 GLKWNVADNKLASGGNDNVVHVYEGTSK----SPILTFDEHKAAVKAMAWSPHKRGVLAT 274 Query: 374 GGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTM 433 GGGT+DR ++IWNV + +S +D+ SQ+C+++WS + EL++ HG+++ L +W +M Sbjct: 275 GGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSM 334 Query: 434 AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELD 476 +A LKGH+ RVL LT+S DG TV S A DETLR W+ F++ Sbjct: 335 DPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFDVS 377 Score = 57.5 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 21/136 (15%), Positives = 51/136 (37%), Gaps = 9/136 (6%) Query: 355 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKE 413 + +++W S++ G ++ + I++V C+ + H +V + W+ H Sbjct: 131 ENEYTSLSWIGAGSHL---AVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNH--- 184 Query: 414 LISGHGFAQNQLVIWKYPTMAKV-AELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 + G ++++ ++ HT V L + +AS D + ++ Sbjct: 185 -VLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEG 243 Query: 473 FELDPARRREREKASA 488 P + KA+ Sbjct: 244 TSKSPILTFDEHKAAV 259 >5L9T-R nrPDB Length = 493 Score = 357 bits (915), Expect = 8e-99, Method: Composition-based stats. Identities = 174/435 (40%), Positives = 237/435 (54%), Gaps = 43/435 (9%) Query: 76 GDRYIPHRSAAQMEVASFLLSKENQPENSQTP-------------TKKEHQKAWALNLNG 122 GDR+IP R+ A V +F EN+ SQ L G Sbjct: 45 GDRFIPSRAGANWSV-NFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAG 103 Query: 123 FDVEE----------------AKILRLSGKPQNAPEGYQNRLKVLYSQKATPG------- 159 + + + S + + N + YS Sbjct: 104 IEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDV-SPYSLSPVSNKSQKLLR 162 Query: 160 SSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQL 219 S RK R I +P ++LDAPE+++D+YLNLVDWSS NVL+V L VYLWSA + + +L Sbjct: 163 SPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRL 222 Query: 220 LQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY 279 + G+ ++SV W + GN +AVGT VQ+WD K+L + H+ARVG+L+WN+ Sbjct: 223 CDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAE 282 Query: 280 ILSSGSRSGHIHHHDVRVAE-HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 LSSGSR I D+R L GH QEVCGL+W+ D + LASGGNDN + VW Sbjct: 283 QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN- 341 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 P+Q +T+H AVKA+AW P Q +LA+GGGT+DR IR WN +G L +D Sbjct: 342 ---HSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT 398 Query: 399 HSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATV 458 SQVC++ WS H EL+S HG++QNQ+++WKYP++ +VA+L GH+ RVL L MSPDG + Sbjct: 399 GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAI 458 Query: 459 ASAAADETLRLWRCF 473 + A DETLR W F Sbjct: 459 VTGAGDETLRFWNVF 473 Score = 94.1 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 30/203 (14%), Positives = 67/203 (33%), Gaps = 47/203 (23%) Query: 189 LVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSA 248 + W++ + + + D + + + +++ + + + W + LA G + Sbjct: 276 ALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDN 335 Query: 249 EVQLWDVQQQKRLRNMTSHSARVGSLSWNSY---ILSSGS--RSGHIHHHDVRVAEH--- 300 ++ +W+ ++ T H A V +++W+ + +L+SG I + + Sbjct: 336 KLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQC 395 Query: 301 ---------------------------------------HVATLSGHSQEVCGLRWAPDG 321 VA L+GHS V L +PDG Sbjct: 396 IDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDG 455 Query: 322 RHLASGGNDNLVNVWPSAPGEGG 344 + +G D + W Sbjct: 456 EAIVTGAGDETLRFWNVFSKTRS 478 Score = 77.5 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 35/169 (20%), Positives = 64/169 (37%), Gaps = 14/169 (8%) Query: 315 LRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATG 374 + W+ + S G V +W + + + + +V +V W + Sbjct: 193 VDWSSLN--VLSVGLGTCVYLWSACTSQVTRLCDLSVEG--DSVTSVGWSERGN---LVA 245 Query: 375 GGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTM 433 GT ++IW+ +G LS ++ H+ V ++ W+ G ++ T Sbjct: 246 VGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ----LSSGSRDRMILQRDIRTP 301 Query: 434 AKVAE--LKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 +E L+GH V L S D +AS D L +W L P ++ Sbjct: 302 PLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQ 350 >4AEZ-A nrPDB Length = 401 Score = 354 bits (907), Expect = 7e-98, Method: Composition-based stats. Identities = 185/409 (45%), Positives = 255/409 (62%), Gaps = 26/409 (6%) Query: 77 DRYIPHR-SAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSG 135 DR+IP R + A V S +S P A A GFD+ R+ Sbjct: 1 DRFIPSRPNTANAFVNSI---------SSDVPFDYSESVAEAC---GFDLNT----RVLA 44 Query: 136 KPQNAPEGYQ-NRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSS 194 +APE + L+ +++ P + R+ + P+R+LDAP I +DYYLNL+DWS+ Sbjct: 45 FKLDAPEAKKPVDLRTQHNRPQRPVVTPAKRRF-NTTPERVLDAPGIIDDYYLNLLDWSN 103 Query: 195 GNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWD 254 NV+AVAL+ +VY+W+A SG + L + ++ Y++SV W +G++L+VG + V ++D Sbjct: 104 LNVVAVALERNVYVWNADSGSVSALAETDE-STYVASVKWSHDGSFLSVGLGNGLVDIYD 162 Query: 255 VQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCG 314 V+ Q +LR M H ARVG LSWN ++LSSGSRSG IHHHDVR+A H + TL GHS EVCG Sbjct: 163 VESQTKLRTMAGHQARVGCLSWNRHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVCG 222 Query: 315 LRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATG 374 L W DG LASGGNDN+V +W + +P T T H AVKAVAWCPWQSN+LATG Sbjct: 223 LAWRSDGLQLASGGNDNVVQIWDARS----SIPKFTKTNHNAAVKAVAWCPWQSNLLATG 278 Query: 375 GGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPT-- 432 GGT D+ I WN +GA ++ VDA SQV S++WSPH KE++S HGF N L IW Y + Sbjct: 279 GGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSG 338 Query: 433 MAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRR 481 + K ++ H +RVL +SPDG +++AA+DE L+ WR ++ D +R Sbjct: 339 LTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHVKRP 387 Score = 74.8 bits (182), Expect = 8e-14, Method: Composition-based stats. Identities = 36/176 (20%), Positives = 64/176 (36%), Gaps = 14/176 (7%) Query: 315 LRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATG 374 L W+ ++ + + V VW + G + T V +V W + L+ G Sbjct: 99 LDWS--NLNVVAVALERNVYVWNADSGSVSALAE---TDESTYVASVKWS-HDGSFLSVG 152 Query: 375 GGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYP-T 432 G + I++V S L + H V + W+ H + G + Sbjct: 153 LGN--GLVDIYDVESQTKLRTMAGHQARVGCLSWNRH----VLSSGSRSGAIHHHDVRIA 206 Query: 433 MAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASA 488 ++ L+GH+S V L DG +AS D +++W P + A+ Sbjct: 207 NHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAV 262 >4BH6-A nrPDB Length = 308 Score = 316 bits (809), Expect = 2e-86, Method: Composition-based stats. Identities = 140/312 (44%), Positives = 210/312 (67%), Gaps = 7/312 (2%) Query: 163 KTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQM 222 K R I +P R+LDAP + +D+Y +L+DWSS +VLAVAL S++L ++GD++ L Sbjct: 2 KQFRQIAKVPYRVLDAPSLADDFYYSLIDWSSTDVLAVALGKSIFLTDNNTGDVVHLCDT 61 Query: 223 EQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILS 282 E +S++WI G++LAVG ++ V+++DV ++K +R ++ H RV LSWN+++L+ Sbjct: 62 E---NEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNHVLT 118 Query: 283 SGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE 342 SGSR I H DVR+ + T+ H+QEVCGL+W LASGGNDN+V+V+ Sbjct: 119 SGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSK- 177 Query: 343 GGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV 402 P+ TF +H+ AVKA+AW P + VLATGGGT+DR ++IWNV + +S +D+ SQ+ Sbjct: 178 ---SPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQI 234 Query: 403 CSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAA 462 C+++WS + EL++ HG+++ L +W +M +A LKGH+ RVL LT+S DG TV S A Sbjct: 235 CNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGA 294 Query: 463 ADETLRLWRCFE 474 DETLR W+ F+ Sbjct: 295 GDETLRYWKLFD 306 Score = 78.3 bits (191), Expect = 8e-15, Method: Composition-based stats. Identities = 30/202 (14%), Positives = 64/202 (31%), Gaps = 48/202 (23%) Query: 187 LNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTS 246 + + W++ + + + D+ + D +E + + + W N LA G + Sbjct: 107 VACLSWNNHVLTSGSRDHRILHRDVRMPDPF-FETIESHTQEVCGLKWNVADNKLASGGN 165 Query: 247 SAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY---ILSSGS--RSGHIHHHDVRVAEHH 301 V +++ + + H A V +++W+ + +L++G + +V + Sbjct: 166 DNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKM 225 Query: 302 ------------------------------------------VATLSGHSQEVCGLRWAP 319 +A L GHS V L + Sbjct: 226 SDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSN 285 Query: 320 DGRHLASGGNDNLVNVWPSAPG 341 DG + SG D + W Sbjct: 286 DGTTVVSGAGDETLRYWKLFDK 307 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 21/136 (15%), Positives = 51/136 (37%), Gaps = 9/136 (6%) Query: 355 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKE 413 + +++W S++ G ++ + I++V C+ + H +V + W+ H Sbjct: 62 ENEYTSLSWIGAGSHL---AVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNH--- 115 Query: 414 LISGHGFAQNQLVIWKYPTMAKV-AELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 + G ++++ ++ HT V L + +AS D + ++ Sbjct: 116 -VLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEG 174 Query: 473 FELDPARRREREKASA 488 P + KA+ Sbjct: 175 TSKSPILTFDEHKAAV 190 >5NNZ-B nrPDB Length = 415 Score = 280 bits (717), Expect = 7e-76, Method: Composition-based stats. Identities = 72/319 (22%), Positives = 134/319 (42%), Gaps = 17/319 (5%) Query: 158 PGSSRKTCRYIPSLPDRILDAPE-IRNDYYLNLVDWSSGNVLA-VALDNSVYLWSASSGD 215 GS +TC+ + L+ E RN Y + G+ +A + D + LWS +G Sbjct: 109 TGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK 168 Query: 216 ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS 275 I +++ + +A G+ +LWD+Q + + + HSA + SLS Sbjct: 169 CYHTF--RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLS 226 Query: 276 WN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLV 333 +N + +GS + D V L GH E+ + D + +G D Sbjct: 227 FNTSGDRIITGSFDHTVVVWDADTG-RKVNILIGHCAEISSASFNWDCSLILTGSMDKTC 285 Query: 334 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACL 393 +W + G+ + T T H + + + ++AT ++D RI++ + C+ Sbjct: 286 KLWDATNGK----CVATLTGHDDEILDSCFD-YTGKLIATA--SADGTARIFSAATRKCI 338 Query: 394 SAVDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMS 452 + ++ H ++ I ++P L++G + IW T + L+GHT + S + Sbjct: 339 AKLEGHEGEISKISFNPQGNHLLTGS--SDKTARIWDAQTGQCLQVLEGHTDEIFSCAFN 396 Query: 453 PDGATVASAAADETLRLWR 471 G V + + D T R+WR Sbjct: 397 YKGNIVITGSKDNTCRIWR 415 Score = 265 bits (677), Expect = 3e-71, Method: Composition-based stats. Identities = 65/313 (20%), Positives = 134/313 (42%), Gaps = 16/313 (5%) Query: 189 LVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWI-KEGNYLAVGTSS 247 ++ S + + D + LW +SG +L +E + ++A+ G+ +A G+ Sbjct: 99 ALNKSGSCFITGSYDRTCKLWDTASG--EELNTLEGHRNVVYAIAFNNPYGDKIATGSFD 156 Query: 248 AEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHHVATL 305 +LW V+ K H+A + LS+N ++++GS D++ E V TL Sbjct: 157 KTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGE-EVYTL 215 Query: 306 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 365 GHS E+ L + G + +G D+ V VW + G + H + + ++ Sbjct: 216 RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRK----VNILIGHCAEISSASFNW 271 Query: 366 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQ 424 S +L G+ D+ ++W+ +G C++ + H + + K + + A Sbjct: 272 DCSLIL---TGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATAS--ADGT 326 Query: 425 LVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRRERE 484 I+ T +A+L+GH + ++ +P G + + ++D+T R+W + E Sbjct: 327 ARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGH 386 Query: 485 KASAAKSSLIHQG 497 + ++G Sbjct: 387 TDEIFSCAFNYKG 399 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 57/295 (19%), Positives = 117/295 (39%), Gaps = 14/295 (4%) Query: 207 YLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTS 266 L S+ ++ +++VA K G+ G+ +LWD + L + Sbjct: 73 KLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEG 132 Query: 267 HSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRH 323 H V ++++N +++GS V + + T GH+ E+ L + P Sbjct: 133 HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCY-HTFRGHTAEIVCLSFNPQSTL 191 Query: 324 LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIR 383 +A+G D +W GE + T H + ++++ ++ G+ D + Sbjct: 192 VATGSMDTTAKLWDIQNGEEVY----TLRGHSAEIISLSFNTSGDRII---TGSFDHTVV 244 Query: 384 IWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGH 442 +W+ +G ++ + H +++ S ++ +++G +W VA L GH Sbjct: 245 VWDADTGRKVNILIGHCAEISSASFNWDCSLILTGS--MDKTCKLWDATNGKCVATLTGH 302 Query: 443 TSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 +L G +A+A+AD T R++ + E + +K S QG Sbjct: 303 DDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQG 357 Score = 118 bits (295), Expect = 6e-27, Method: Composition-based stats. Identities = 31/160 (19%), Positives = 55/160 (34%), Gaps = 3/160 (1%) Query: 340 PGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH 399 + + H + VA S + G+ DR ++W+ SG L+ ++ H Sbjct: 77 NSNHTFYLFKVLKAHILPLTNVALNKSGSCFI---TGSYDRTCKLWDTASGEELNTLEGH 133 Query: 400 SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVA 459 V + + G +W T +GHT+ ++ L+ +P VA Sbjct: 134 RNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVA 193 Query: 460 SAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR 499 + + D T +LW + A S G R Sbjct: 194 TGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDR 233 >5MZH-A nrPDB Length = 452 Score = 276 bits (706), Expect = 1e-74, Method: Composition-based stats. Identities = 67/320 (20%), Positives = 132/320 (41%), Gaps = 17/320 (5%) Query: 158 PGSSRKTCRYIPS-LPDRILDAPEIRNDYYLNLVDWSSGN-VLAVALDNSVYLWSASSGD 215 GS +TC+ + + + +N Y + G+ ++ + D + LW A +G Sbjct: 111 TGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQ 170 Query: 216 ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS 275 + ++ I +++ + +A G+ +LWDV+ + + H A + SL Sbjct: 171 LY--YTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLG 228 Query: 276 WN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLV 333 +N ++ +GS DVR V LSGH EV ++ G + SG D Sbjct: 229 FNTGGDLIVTGSFDHDSRLWDVRTG-QCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTS 287 Query: 334 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACL 393 +W G L H V VA+ + +++ ++D R+++ +G C Sbjct: 288 RLWDVRSG----RCLSVKQGHTDEVLDVAFDAAGTKMVS---ASADGSARLYHTLTGVCQ 340 Query: 394 SAVDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMS 452 + H ++ + ++P LI+ + +W T + L+GHT + S + Sbjct: 341 HTLVGHEGEISKVAFNPQGTRLITAS--SDKTCRLWDCDTGECLQVLEGHTDEIFSCAFN 398 Query: 453 PDGATVASAAADETLRLWRC 472 +G + + + D T R+W+ Sbjct: 399 YEGDFIITGSKDNTCRIWKA 418 Score = 268 bits (685), Expect = 4e-72, Method: Composition-based stats. Identities = 65/313 (20%), Positives = 131/313 (41%), Gaps = 16/313 (5%) Query: 189 LVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWI-KEGNYLAVGTSS 247 + S + + D + +W+ +G ++ +E + ++A+ G+ + G+ Sbjct: 101 AFNKSGDRFITGSYDRTCKVWNTFTG--EEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFD 158 Query: 248 AEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHHVATL 305 +LWD + + H + LS+N I+++GS DV + ATL Sbjct: 159 KTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQER-ATL 217 Query: 306 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 365 +GH E+ L + G + +G D+ +W G+ + + H+G V + + Sbjct: 218 AGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQ----CVHVLSGHRGEVSSTQFNY 273 Query: 366 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQ 424 + V++ G+ D R+W+V SG CLS H+ V + + +++S A Sbjct: 274 AGTLVVS---GSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSAS--ADGS 328 Query: 425 LVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRRERE 484 ++ T L GH + + +P G + +A++D+T RLW C + + E Sbjct: 329 ARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQVLEGH 388 Query: 485 KASAAKSSLIHQG 497 + ++G Sbjct: 389 TDEIFSCAFNYEG 401 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 55/282 (19%), Positives = 113/282 (40%), Gaps = 14/282 (4%) Query: 222 MEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---S 278 + +++ A+ K G+ G+ ++W+ + + + H V ++++N Sbjct: 90 LRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYG 149 Query: 279 YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 + +GS D + + TL GH E+ L + P +A+G DN +W Sbjct: 150 DKIVTGSFDKTCKLWDAYTGQLY-YTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDV 208 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 G+ T H+ + ++ + ++ G+ D R+W+V +G C+ + Sbjct: 209 ETGQER----ATLAGHRAEIVSLGFNTGGDLIV---TGSFDHDSRLWDVRTGQCVHVLSG 261 Query: 399 H-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGAT 457 H +V S ++ ++SG +W + ++ +GHT VL + G Sbjct: 262 HRGEVSSTQFNYAGTLVVSGS--IDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTK 319 Query: 458 VASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR 499 + SA+AD + RL+ + +K + QG R Sbjct: 320 MVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTR 361 Score = 182 bits (461), Expect = 4e-46, Method: Composition-based stats. Identities = 51/247 (20%), Positives = 98/247 (39%), Gaps = 14/247 (5%) Query: 257 QQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCG 314 + + +H + + ++N +GS + E V TL GH V Sbjct: 83 SFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGE-EVFTLEGHKNVVYA 141 Query: 315 LRWA-PDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLAT 373 + + P G + +G D +W + G+ + T HQ + +++ P QS ++AT Sbjct: 142 IAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYY----TLKGHQTEIVCLSFNP-QSTIIAT 196 Query: 374 GGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPT 432 G+ D ++W+V +G + + H +++ S+ ++ +++G ++L W T Sbjct: 197 --GSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRL--WDVRT 252 Query: 433 MAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSS 492 V L GH V S + G V S + D T RLW ++ + Sbjct: 253 GQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVA 312 Query: 493 LIHQGIR 499 G + Sbjct: 313 FDAAGTK 319 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 31/192 (16%), Positives = 66/192 (34%), Gaps = 6/192 (3%) Query: 156 ATPGSSRKTCRYIPSLPDRILD-APEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSG 214 GS R + + R + +++ V++ ++D + LW SG Sbjct: 236 IVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSG 295 Query: 215 DILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSL 274 L + Q + + VA+ G + ++ +L+ + H + + Sbjct: 296 RCLSVKQ--GHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKV 353 Query: 275 SWNSY--ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNL 332 ++N L + S D E + L GH+ E+ + +G + +G DN Sbjct: 354 AFNPQGTRLITASSDKTCRLWDCDTGE-CLQVLEGHTDEIFSCAFNYEGDFIITGSKDNT 412 Query: 333 VNVWPSAPGEGG 344 +W + Sbjct: 413 CRIWKALTASSQ 424 Score = 117 bits (293), Expect = 1e-26, Method: Composition-based stats. Identities = 27/157 (17%), Positives = 57/157 (36%), Gaps = 8/157 (5%) Query: 342 EGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ 401 + + H + A+ + G+ DR ++WN +G + ++ H Sbjct: 81 HHSFTLFKVLRAHILPLTNCAFNKSGDRFI---TGSYDRTCKVWNTFTGEEVFTLEGHKN 137 Query: 402 VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASA 461 V + + G +W T LKGH + ++ L+ +P +A+ Sbjct: 138 VVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATG 197 Query: 462 AADETLRLWRCFELDPARRREREKASAAKSSLIHQGI 498 + D T +LW +ER + ++ ++ G Sbjct: 198 SMDNTAKLWDV-----ETGQERATLAGHRAEIVSLGF 229 >1VYH-C nrPDB Length = 410 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 85/422 (20%), Positives = 157/422 (37%), Gaps = 48/422 (11%) Query: 82 HRSAAQMEVASFLLSKENQPENS----------QTPTKKEHQKAWALNLNGFDVEEAKIL 131 R +A +L S + S K++ + K++ Sbjct: 7 QRDELNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVM 66 Query: 132 RLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVD 191 L K A E + + + + R +Y S + + + Sbjct: 67 ELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSV---- 122 Query: 192 WSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQ 251 +++ + D ++ +W +GD + ++ + + +++ G LA ++ ++ Sbjct: 123 -----MVSASEDATIKVWDYETGDFER--TLKGHTDSVQDISFDHSGKLLASCSADMTIK 175 Query: 252 LWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHS 309 LWD Q + +R M H V S+S N + S SR I +V+ + V T +GH Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTG-YCVKTFTGHR 234 Query: 310 QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 369 + V +R DG +AS ND V VW A E +H+ V+ ++W P S Sbjct: 235 EWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAE----LREHRHVVECISWAPESSY 290 Query: 370 VLATG-----------------GGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHY 411 + G+ D+ I++W+V +G CL + H V +L+ Sbjct: 291 SSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGG 350 Query: 412 KELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 K ++S L +W Y + L H V SL V + + D+T+++W Sbjct: 351 KFILSCAD--DKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Query: 472 CF 473 C Sbjct: 409 CR 410 Score = 210 bits (535), Expect = 9e-55, Method: Composition-based stats. Identities = 56/294 (19%), Positives = 108/294 (36%), Gaps = 29/294 (9%) Query: 221 QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--S 278 + ++ V + + + + A +++WD + R + H+ V +S++ Sbjct: 103 ALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSG 162 Query: 279 YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 +L+S S I D + E + T+ GH V + P+G H+ S D + +W Sbjct: 163 KLLASCSADMTIKLWDFQGFE-CIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEV 221 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 G ++TFT H+ V+ V + + + ++D+ +R+W V + C + + Sbjct: 222 QTG----YCVKTFTGHREWVRMVRPNQDGTLIASC---SNDQTVRVWVVATKECKAELRE 274 Query: 399 HSQVC-SILWSPHYKEL------------------ISGHGFAQNQLVIWKYPTMAKVAEL 439 H V I W+P G + +W T + L Sbjct: 275 HRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTL 334 Query: 440 KGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSL 493 GH + V + G + S A D+TLR+W + + Sbjct: 335 VGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDF 388 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 45/260 (17%), Positives = 92/260 (35%), Gaps = 31/260 (11%) Query: 260 RLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRW 317 ++ H + V + ++ ++ S S I D + TL GH+ V + + Sbjct: 100 EKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGD-FERTLKGHTDSVQDISF 158 Query: 318 APDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGT 377 G+ LAS D + +W G+ ++T H V +V+ P ++++ + Sbjct: 159 DHSGKLLASCSADMTIKLWDF----QGFECIRTMHGHDHNVSSVSIMPNGDHIVS---AS 211 Query: 378 SDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVA 437 D+ I++W V +G C+ H + + P+ + + +W T A Sbjct: 212 RDKTIKMWEVQTGYCVKTFTGH-REWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKA 270 Query: 438 ELKGHTSRVLSLTMSPD--------------------GATVASAAADETLRLWRCFELDP 477 EL+ H V ++ +P+ G + S + D+T+++W Sbjct: 271 ELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMC 330 Query: 478 ARRREREKASAAKSSLIHQG 497 G Sbjct: 331 LMTLVGHDNWVRGVLFHSGG 350 >5M25-A nrPDB Length = 434 Score = 253 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 76/284 (26%), Positives = 126/284 (44%), Gaps = 21/284 (7%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256 + + + D + +W A G + + + G IS VAW + N L + +++WDV Sbjct: 160 LASSSADKLIKIWGAYDGKFEKTISGHKLG--ISDVAWSSDSNLLVSASDDKTLKIWDVS 217 Query: 257 QQKRLRNMTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCG 314 K L+ + HS V ++N ++ SGS + DV+ + + TL HS V Sbjct: 218 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK-CLKTLPAHSDPVSA 276 Query: 315 LRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG-AVKAVAWCPWQSNVLAT 373 + + DG + S D L +W +A G+ L+T V V + P +LA Sbjct: 277 VHFNRDGSLIVSSSYDGLCRIWDTASGQ----CLKTLIDDDNPPVSFVKFSPNGKYILA- 331 Query: 374 GGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSP----HYKELISGHGFAQNQLVIWK 429 T D +++W+ G CL H +++ K ++SG N + IW Sbjct: 332 --ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS--EDNLVYIWN 387 Query: 430 YPTMAKVAELKGHTSRVLSLTMSPDGATVASAA--ADETLRLWR 471 T V +L+GHT V+S P +ASAA D+T++LW+ Sbjct: 388 LQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 431 Score = 228 bits (580), Expect = 6e-60, Method: Composition-based stats. Identities = 60/276 (21%), Positives = 113/276 (40%), Gaps = 17/276 (6%) Query: 220 LQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--N 277 + + +SSV + G +LA ++ +++W K + ++ H + ++W + Sbjct: 139 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 198 Query: 278 SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP 337 S +L S S + DV + + TL GHS V + P + SG D V +W Sbjct: 199 SNLLVSASDDKTLKIWDVSSGK-CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 257 Query: 338 SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV- 396 G+ L+T H V AV + S ++++ + D RIW+ SG CL + Sbjct: 258 VKTGK----CLKTLPAHSDPVSAVHFNRDGSLIVSS---SYDGLCRIWDTASGQCLKTLI 310 Query: 397 -DAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSL--TMSP 453 D + V + +SP+ K +++ N L +W Y + GH + + S Sbjct: 311 DDDNPPVSFVKFSPNGKYILAAT--LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 368 Query: 454 D-GATVASAAADETLRLWRCFELDPARRREREKASA 488 G + S + D + +W + ++ + Sbjct: 369 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 404 Score = 193 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 52/277 (18%), Positives = 116/277 (41%), Gaps = 12/277 (4%) Query: 158 PGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGN--VLAVALDNSVYLWSASSGD 215 S+ K + + + ++ V WSS + +++ + D ++ +W SSG Sbjct: 162 SSSADKLIKIWGAYDGKFEKTISGH-KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK 220 Query: 216 ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS 275 L+ ++ Y+ + + N + G+ V++WDV+ K L+ + +HS V ++ Sbjct: 221 CLK--TLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH 278 Query: 276 WN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLV 333 +N ++ S S G D + + + V ++++P+G+++ + DN + Sbjct: 279 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL 338 Query: 334 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACL 393 +W + G+ L+T+T H+ + + G+ D + IWN+ + + Sbjct: 339 KLWDYSKGK----CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 394 Query: 394 SAVDAHSQVC-SILWSPHYKELISGHGFAQNQLVIWK 429 + H+ V S P + S + +WK Sbjct: 395 QKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 431 Score = 127 bits (320), Expect = 8e-30, Method: Composition-based stats. Identities = 32/160 (20%), Positives = 59/160 (36%), Gaps = 6/160 (3%) Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 P + + T H AV +V + P + ++ ++D+ I+IW G + Sbjct: 129 TPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASS---SADKLIKIWGAYDGKFEKTISG 185 Query: 399 HS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGAT 457 H + + WS L+S L IW + + LKGH++ V +P Sbjct: 186 HKLGISDVAWSSDSNLLVSASD--DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 243 Query: 458 VASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 + S + DE++R+W + + G Sbjct: 244 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDG 283 >3DM0-A nrPDB Length = 694 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 84/457 (18%), Positives = 170/457 (37%), Gaps = 78/457 (17%) Query: 71 PSKP-------GGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGF 123 PSKP G + P++ A+ + ++LL+ E + + A+ L + Sbjct: 254 PSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEG------LEAVNKDKPLGAVALKSY 307 Query: 124 DVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSL--PDRILDAPE- 180 + E AK R++ +NA +G +++ + + + + +DA Sbjct: 308 EEELAKDPRIAATMENAQKG-----EIMPNIPQMSAFWYAVRTAVINAASGRQTVDAALA 362 Query: 181 ------------------IRNDYYLNLVDWSSGNVL-AVALDNSVYLWSASSGDI---LQ 218 + + +++ + + D S+ LW + D + Sbjct: 363 AAQTNAAAGLVLKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVA 422 Query: 219 LLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW-- 276 ++ ++ V +G + G+ E++LWD+ R H+ V S+++ Sbjct: 423 QRRLTGHSHFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSL 482 Query: 277 NSYILSSGSRSGHIHHHDVRVAEHHVATL--SGHSQEVCGLRWAPDG--RHLASGGNDNL 332 ++ + S SR I + + + GH V +R++P+ + S D Sbjct: 483 DNRQIVSASRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKT 542 Query: 333 VNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGAC 392 V VW + + T H G V VA P S G D + +W++ G Sbjct: 543 VKVWNLSNCK----LRSTLAGHTGYVSTVAVSPDGS---LCASGGKDGVVLLWDLAEGKK 595 Query: 393 LSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTS-------- 444 L +++A+S + ++ +SP+ L + ++ + IW + + V +LK Sbjct: 596 LYSLEANSVIHALCFSPNRYWLCAA---TEHGIKIWDLESKSIVEDLKVDLKAEAEKADN 652 Query: 445 -----------RVLSLTMSPDGATVASAAADETLRLW 470 SL S DG+T+ S D +R+W Sbjct: 653 SGPAATKRKVIYCTSLNWSADGSTLFSGYTDGVIRVW 689 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 56/232 (24%), Positives = 93/232 (40%), Gaps = 20/232 (8%) Query: 263 NMTSHSARVGSLSW---NSYILSSGSRSGHIHHH----DVRVAEHHVATLSGHSQEVCGL 315 M +H+ V +++ N+ I+ S SR I D + L+GHS V + Sbjct: 377 TMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDV 436 Query: 316 RWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGG 375 + DG+ SG D + +W A G + F H V +VA+ +++ Sbjct: 437 VLSSDGQFALSGSWDGELRLWDLAAGVST----RRFVGHTKDVLSVAFSLDNRQIVS--- 489 Query: 376 GTSDRHIRIWNVCSGACLSAV----DAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKY 430 + DR I++WN G C + + H V + +SP+ + + +W Sbjct: 490 ASRDRTIKLWNTL-GECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNL 548 Query: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRRE 482 + L GHT V ++ +SPDG+ AS D + LW E E Sbjct: 549 SNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLE 600 Score = 122 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 36/205 (17%), Positives = 76/205 (37%), Gaps = 17/205 (8%) Query: 303 ATLSGHSQEVCGLRWAP--DGRHLASGGNDNLVNVWPSAPGEGGW-VPLQTFTQHQGAVK 359 T+ H+ V + P + + S D + +W + + V + T H V+ Sbjct: 376 GTMRAHTDMVTAIA-TPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVE 434 Query: 360 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGH 418 V L+ G+ D +R+W++ +G H+ V S+ +S ++++S Sbjct: 435 DVVLSSDGQFALS---GSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSAS 491 Query: 419 GFAQNQLVIWKYPTMAKVAEL----KGHTSRVLSLTMSPDG--ATVASAAADETLRLWRC 472 + +W + +GH V + SP+ T+ SA+ D+T+++W Sbjct: 492 --RDRTIKLWNTL-GECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNL 548 Query: 473 FELDPARRREREKASAAKSSLIHQG 497 + ++ G Sbjct: 549 SNCKLRSTLAGHTGYVSTVAVSPDG 573 Score = 116 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 30/230 (13%), Positives = 81/230 (35%), Gaps = 28/230 (12%) Query: 180 EIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQM--EQPGEYISSVAWIKE 237 D + +++ + D ++ LW+ G+ + E +++S V + Sbjct: 470 GHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTL-GECKYTISEGGEGHRDWVSCVRFSPN 528 Query: 238 GNY--LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVG--SLSWNSYILSSGSRSGHIHHH 293 + + V++W++ K + H+ V ++S + + +SG + G + Sbjct: 529 TLQPTIVSASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLW 588 Query: 294 DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ 353 D+ + + +L + + L ++P+ R+ ++ + +W Sbjct: 589 DLAEGKK-LYSLEA-NSVIHALCFSPN-RYWLCAATEHGIKIWDLESKSIVEDLKVDLKA 645 Query: 354 H-------------QGAVKAVA--WCPWQSNVLATGGGTSDRHIRIWNVC 388 + + + W S + + G +D IR+W + Sbjct: 646 EAEKADNSGPAATKRKVIYCTSLNWSADGSTLFS---GYTDGVIRVWGIG 692 >2H9P-A nrPDB Length = 329 Score = 248 bits (633), Expect = 5e-66, Method: Composition-based stats. Identities = 76/284 (26%), Positives = 126/284 (44%), Gaps = 21/284 (7%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256 + + + D + +W A G + + + G IS VAW + N L + +++WDV Sbjct: 55 LASSSADKLIKIWGAYDGKFEKTISGHKLG--ISDVAWSSDSNLLVSASDDKTLKIWDVS 112 Query: 257 QQKRLRNMTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCG 314 K L+ + HS V ++N ++ SGS + DV+ + + TL HS V Sbjct: 113 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK-CLKTLPAHSDPVSA 171 Query: 315 LRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG-AVKAVAWCPWQSNVLAT 373 + + DG + S D L +W +A G+ L+T V V + P +LA Sbjct: 172 VHFNRDGSLIVSSSYDGLCRIWDTASGQ----CLKTLIDDDNPPVSFVKFSPNGKYILA- 226 Query: 374 GGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSP----HYKELISGHGFAQNQLVIWK 429 T D +++W+ G CL H +++ K ++SG N + IW Sbjct: 227 --ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS--EDNLVYIWN 282 Query: 430 YPTMAKVAELKGHTSRVLSLTMSPDGATVASAA--ADETLRLWR 471 T V +L+GHT V+S P +ASAA D+T++LW+ Sbjct: 283 LQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 326 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 60/276 (21%), Positives = 113/276 (40%), Gaps = 17/276 (6%) Query: 220 LQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--N 277 + + +SSV + G +LA ++ +++W K + ++ H + ++W + Sbjct: 34 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 93 Query: 278 SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP 337 S +L S S + DV + + TL GHS V + P + SG D V +W Sbjct: 94 SNLLVSASDDKTLKIWDVSSGK-CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 152 Query: 338 SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV- 396 G+ L+T H V AV + S ++++ + D RIW+ SG CL + Sbjct: 153 VKTGK----CLKTLPAHSDPVSAVHFNRDGSLIVSS---SYDGLCRIWDTASGQCLKTLI 205 Query: 397 -DAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSL--TMSP 453 D + V + +SP+ K +++ N L +W Y + GH + + S Sbjct: 206 DDDNPPVSFVKFSPNGKYILAAT--LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 263 Query: 454 D-GATVASAAADETLRLWRCFELDPARRREREKASA 488 G + S + D + +W + ++ + Sbjct: 264 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 299 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 52/277 (18%), Positives = 116/277 (41%), Gaps = 12/277 (4%) Query: 158 PGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGN--VLAVALDNSVYLWSASSGD 215 S+ K + + + ++ V WSS + +++ + D ++ +W SSG Sbjct: 57 SSSADKLIKIWGAYDGKFEKTISGH-KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK 115 Query: 216 ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS 275 L+ ++ Y+ + + N + G+ V++WDV+ K L+ + +HS V ++ Sbjct: 116 CLK--TLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH 173 Query: 276 WN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLV 333 +N ++ S S G D + + + V ++++P+G+++ + DN + Sbjct: 174 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL 233 Query: 334 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACL 393 +W + G+ L+T+T H+ + + G+ D + IWN+ + + Sbjct: 234 KLWDYSKGK----CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 289 Query: 394 SAVDAHSQVC-SILWSPHYKELISGHGFAQNQLVIWK 429 + H+ V S P + S + +WK Sbjct: 290 QKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 326 Score = 125 bits (314), Expect = 4e-29, Method: Composition-based stats. Identities = 32/160 (20%), Positives = 59/160 (36%), Gaps = 6/160 (3%) Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 P + + T H AV +V + P + ++ ++D+ I+IW G + Sbjct: 24 TPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASS---SADKLIKIWGAYDGKFEKTISG 80 Query: 399 HS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGAT 457 H + + WS L+S L IW + + LKGH++ V +P Sbjct: 81 HKLGISDVAWSSDSNLLVSASD--DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 138 Query: 458 VASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 + S + DE++R+W + + G Sbjct: 139 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDG 178 >6G51-g nrPDB Length = 317 Score = 245 bits (624), Expect = 5e-65, Method: Composition-based stats. Identities = 62/294 (21%), Positives = 115/294 (39%), Gaps = 26/294 (8%) Query: 195 GNVLAVALDNSVYLWSASSGDI---LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQ 251 +L+ + D ++ +W + + + + ++S V +G + G+ ++ Sbjct: 29 DMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLR 88 Query: 252 LWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHS 309 LWD+ R H+ V S+++ ++ + SGSR I + + HS Sbjct: 89 LWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHS 148 Query: 310 QEVCGLRWAPD--GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQ 367 + V +R++P+ + S G D LV VW A + H G + V P Sbjct: 149 EWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT----NHIGHTGYLNTVTVSPDG 204 Query: 368 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVI 427 S G D +W++ G L +D + ++ +SP+ L + G + + I Sbjct: 205 S---LCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPS---IKI 258 Query: 428 WKYPTMAKVAEL---------KGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 W V EL K + SL S DG T+ + D +R+W+ Sbjct: 259 WDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 52/231 (22%), Positives = 86/231 (37%), Gaps = 18/231 (7%) Query: 263 NMTSHSARVGSLSWNSY---ILSSGSRSGHIHHHDVRVAEHHVAT----LSGHSQEVCGL 315 + H+ V ++ ++ S SR I + E + L GHS V + Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 Query: 316 RWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGG 375 + DG+ SG D + +W G + F H V +VA+ +++ Sbjct: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTT----RRFVGHTKDVLSVAFSSDNRQIVS--- 122 Query: 376 GTSDRHIRIWNVCSGACLSAVDAHS---QVCSILWSPHYKELISGHGFAQNQLVIWKYPT 432 G+ D+ I++WN G C V S V + +SP+ I + +W Sbjct: 123 GSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181 Query: 433 MAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRRER 483 GHT + ++T+SPDG+ AS D LW E + Sbjct: 182 CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 35/201 (17%), Positives = 71/201 (35%), Gaps = 11/201 (5%) Query: 303 ATLSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWPSAPGEGGW-VPLQTFTQHQGAVKA 360 TL GH+ V + P + S D + +W E + +P + H V Sbjct: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68 Query: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHG 419 V L+ G+ D +R+W++ +G H+ V S+ +S ++++SG Sbjct: 69 VVISSDGQFALS---GSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS- 124 Query: 420 FAQNQLVIWK-YPTMAKVAELKGHTSRVLSLTMSPD--GATVASAAADETLRLWRCFELD 476 + +W + + H+ V + SP+ + S D+ +++W Sbjct: 125 -RDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK 183 Query: 477 PARRREREKASAAKSSLIHQG 497 ++ G Sbjct: 184 LKTNHIGHTGYLNTVTVSPDG 204 Score = 112 bits (279), Expect = 5e-25, Method: Composition-based stats. Identities = 42/244 (17%), Positives = 85/244 (34%), Gaps = 17/244 (6%) Query: 158 PGSSRKTCRYIP-SLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDI 216 GS T R + D + +++ + D ++ LW+ G Sbjct: 80 SGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL-GVC 138 Query: 217 LQLLQMEQPGEYISSVAWIKEGN--YLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVG-- 272 +Q E E++S V + + + V++W++ K N H+ + Sbjct: 139 KYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTV 198 Query: 273 SLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNL 332 ++S + + +SG + G D+ +H + TL G + L ++P+ R+ Sbjct: 199 TVSPDGSLCASGGKDGQAMLWDLNEGKH-LYTLDG-GDIINALCFSPN-RYWLCAATGPS 255 Query: 333 VNVWPSAPGEGGWVPLQTFTQHQG-----AVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 387 + +W Q ++AW + A G +D +R+W V Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA---GYTDNLVRVWQV 312 Query: 388 CSGA 391 G Sbjct: 313 TIGT 316 Score = 97.2 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 41/203 (20%), Positives = 78/203 (38%), Gaps = 16/203 (7%) Query: 153 SQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGN----VLAVALDNSVYL 208 +++ GS KT + +L + + +++ V +S + +++ D V + Sbjct: 117 NRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 Query: 209 WSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHS 268 W+ + + Y+++V +G+ A G + LWD+ + K L + Sbjct: 177 WNLA--NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD 234 Query: 269 A-RVGSLSWNSYILSSGSRSGHIHHHDVRVA------EHHVATLSGHSQEV--CGLRWAP 319 S N Y L + I D+ + V + S ++ L W+ Sbjct: 235 IINALCFSPNRYWL-CAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSA 293 Query: 320 DGRHLASGGNDNLVNVWPSAPGE 342 DG+ L +G DNLV VW G Sbjct: 294 DGQTLFAGYTDNLVRVWQVTIGT 316 Score = 39.8 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 19/82 (23%), Positives = 32/82 (39%), Gaps = 8/82 (9%) Query: 187 LNLVDWSSGNV-LAVALDNSVYLWSASSGDILQLLQMEQPGEY-------ISSVAWIKEG 238 +N + +S L A S+ +W I+ L+ E +S+AW +G Sbjct: 236 INALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADG 295 Query: 239 NYLAVGTSSAEVQLWDVQQQKR 260 L G + V++W V R Sbjct: 296 QTLFAGYTDNLVRVWQVTIGTR 317 >4V6W-Ag nrPDB Length = 318 Score = 240 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 65/300 (21%), Positives = 119/300 (39%), Gaps = 27/300 (9%) Query: 191 DWSSGNVLAVALDNSVYLWSASSGDILQL----LQMEQPGEYISSVAWIKEGNYLAVGTS 246 +++ + D ++ +W + + ++ +IS V +GNY G+ Sbjct: 25 PKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVLSSDGNYALSGSW 84 Query: 247 SAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVAT 304 ++LWD+ K R H+ V S+++ ++ + SGSR I + Sbjct: 85 DQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTLAECKFTIQ 144 Query: 305 LSGHSQEVCGLRWAPD--GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 GH+ V +R++P+ + S G D V VW A + H G + V Sbjct: 145 EDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLK----NNHHGHNGYLNTVT 200 Query: 363 WCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQ 422 P S G D +W++ G L ++ + + ++ +SP+ L +G + Sbjct: 201 VSPDGS---LCTSGGKDSKALLWDLNDGKNLYTLEHNDIINALCFSPNRYWLCVAYGPS- 256 Query: 423 NQLVIWKYPTMAKVAEL---------KGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 + IW V EL K + LSL S DG T+ + +D T+R+W+ Sbjct: 257 --IKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQVS 314 Score = 158 bits (400), Expect = 4e-39, Method: Composition-based stats. Identities = 49/232 (21%), Positives = 87/232 (37%), Gaps = 21/232 (9%) Query: 263 NMTSHSARVGSLSWNSY---ILSSGSRSGHIHHH------DVRVAEHHVATLSGHSQEVC 313 + H+ V ++ N + S SR + D L GHS + Sbjct: 10 TLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQ-KRLYGHSHFIS 68 Query: 314 GLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLAT 373 + + DG + SG D + +W A G+ + F H V +VA+ +++ Sbjct: 69 DVVLSSDGNYALSGSWDQTLRLWDLAAGKTT----RRFEGHTKDVLSVAFSADNRQIVS- 123 Query: 374 GGGTSDRHIRIWNVCSGACLSAV--DAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKY 430 G+ D+ I++WN + C + D H+ V + +SP++ I + +W Sbjct: 124 --GSRDKTIKLWNTLA-ECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNL 180 Query: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRRE 482 GH + ++T+SPDG+ S D LW + E Sbjct: 181 ANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE 232 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 39/202 (19%), Positives = 73/202 (36%), Gaps = 12/202 (5%) Query: 303 ATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGG--WVPLQTFTQHQGAVK 359 TL GH+ V + P D + S D + VW E P + H + Sbjct: 9 GTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFIS 68 Query: 360 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGH 418 V + L+ G+ D+ +R+W++ +G + H+ V S+ +S ++++SG Sbjct: 69 DVVLSSDGNYALS---GSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGS 125 Query: 419 GFAQNQLVIWK-YPTMAKVAELKGHTSRVLSLTMSPD--GATVASAAADETLRLWRCFEL 475 + +W + GHT V + SP+ + S D T+++W Sbjct: 126 --RDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANC 183 Query: 476 DPARRREREKASAAKSSLIHQG 497 ++ G Sbjct: 184 KLKNNHHGHNGYLNTVTVSPDG 205 Score = 118 bits (295), Expect = 6e-27, Method: Composition-based stats. Identities = 43/306 (14%), Positives = 106/306 (34%), Gaps = 27/306 (8%) Query: 96 SKENQPENSQTPTKKEHQKAWALNLN---GFDVEEAKILRLSGKPQNAPEGYQNRLKVLY 152 + P+ + ++ + W L + + + ++ S + + Sbjct: 23 TNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVLSSDGNYAL-- 80 Query: 153 SQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLN-LVDWSSGNVLAVALDNSVYLWSA 211 GS +T R + E L+ + +++ + D ++ LW+ Sbjct: 81 -----SGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNT 135 Query: 212 SSGDILQLLQMEQPGEYISSVAWIKEGN--YLAVGTSSAEVQLWDVQQQKRLRNMTSHSA 269 + + +Q + +++S V + + + V++W++ K N H+ Sbjct: 136 LA-ECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNHHGHNG 194 Query: 270 RVG--SLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASG 327 + ++S + + +SG + D+ ++ + TL H+ + L ++P+ R+ Sbjct: 195 YLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKN-LYTLE-HNDIINALCFSPN-RYWLCV 251 Query: 328 GNDNLVNVWPSAPGEGGWVPLQTFTQHQG-----AVKAVAWCPWQSNVLATGGGTSDRHI 382 + +W A + ++AW + A G SD I Sbjct: 252 AYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFA---GYSDNTI 308 Query: 383 RIWNVC 388 R+W V Sbjct: 309 RVWQVS 314 Score = 66.3 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 28/204 (13%), Positives = 64/204 (31%), Gaps = 59/204 (28%) Query: 153 SQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGN----VLAVALDNSVYL 208 +++ GS KT + +L + E + +++ V +S + +++ D +V + Sbjct: 118 NRQIVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKV 177 Query: 209 WSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHS 268 W+ + + Y+++V +G+ G ++ LWD+ K L + H+ Sbjct: 178 WNLA--NCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE-HN 234 Query: 269 ARVGSLSW---------------------------------------------------- 276 + +L + Sbjct: 235 DIINALCFSPNRYWLCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWST 294 Query: 277 NSYILSSGSRSGHIHHHDVRVAEH 300 + L +G I V V+ H Sbjct: 295 DGQTLFAGYSDNTIRVWQVSVSAH 318 >5FL8-q nrPDB Length = 515 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 68/335 (20%), Positives = 120/335 (35%), Gaps = 59/335 (17%) Query: 186 YLNLVDWSSG--NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK------- 236 ++ V WS + ++DN++ LW SG L + ++I+S++W Sbjct: 188 WVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGD-ALRGHSKWITSLSWEPIHLVKPG 246 Query: 237 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY-ILSSGSRSGHIHHHDV 295 LA + +++WD + M+ H+ V + W +L SGS + D+ Sbjct: 247 SKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQGLLYSGSHDRTVRVWDI 306 Query: 296 RVAEHHVATLSGHSQEVCGLRWAPD----------------------------------- 320 + L H+ V L + D Sbjct: 307 NSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKK 366 Query: 321 ----GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGG 376 + + +D + +W P+ T HQ V VA+ P +++ Sbjct: 367 NGNSEEMMVTASDDYTMFLWNPLKSTK---PIARMTGHQKLVNHVAFSPDGRYIVS---A 420 Query: 377 TSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAK 435 + D I++W+ G +S H + V + WS + L+S L +W T Sbjct: 421 SFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCS--KDTTLKVWDVRTRKL 478 Query: 436 VAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 +L GH V ++ S DG V S D+ +RLW Sbjct: 479 SVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 184 bits (467), Expect = 8e-47, Method: Composition-based stats. Identities = 61/315 (19%), Positives = 107/315 (33%), Gaps = 58/315 (18%) Query: 224 QPGEYISSVAWIKE-GNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYI 280 G I A+ + + G ++WD Q + + H V +SW + + Sbjct: 141 GHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDGEV 200 Query: 281 LSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP-------DGRHLASGGNDNLV 333 +++GS I D + + L GHS+ + L W P LAS D + Sbjct: 201 IATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTI 260 Query: 334 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-GAC 392 +W + V T + H +V V W +L + G+ DR +R+W++ S G C Sbjct: 261 KIWDTVS----RVCQYTMSGHTNSVSCVKW--GGQGLLYS--GSHDRTVRVWDINSQGRC 312 Query: 393 LSAVDAH--------------------------------------SQVCSILWSPHYKEL 414 ++ + +H I E Sbjct: 313 INILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEE 372 Query: 415 ISGHGFAQNQLVIWK-YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 + + +W + +A + GH V + SPDG + SA+ D +++LW Sbjct: 373 MMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGR 432 Query: 474 ELDPARRREREKASA 488 + AS Sbjct: 433 DGKFISTFRGHVASV 447 Score = 161 bits (407), Expect = 6e-40, Method: Composition-based stats. Identities = 57/325 (17%), Positives = 116/325 (35%), Gaps = 64/325 (19%) Query: 156 ATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDW---------SSGNVLAVALDNSV 206 GS T R + L + ++ + W S + + + D ++ Sbjct: 201 IATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTI 260 Query: 207 YLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQ-QKRLRNMT 265 +W S + M +S V W +G L G+ V++WD+ + + + Sbjct: 261 KIWDTVS--RVCQYTMSGHTNSVSCVKWGGQG-LLYSGSHDRTVRVWDINSQGRCINILK 317 Query: 266 SHSARVGSLSWN-----------------------------------------SYILSSG 284 SH+ V LS + ++ + Sbjct: 318 SHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTA 377 Query: 285 SRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG 344 S + + + +A ++GH + V + ++PDGR++ S DN + +W G+ Sbjct: 378 SDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGK-- 435 Query: 345 WVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVC 403 + TF H +V VAW +++ + D +++W+V + + H +V Sbjct: 436 --FISTFRGHVASVYQVAWSSDCRLLVSC---SKDTTLKVWDVRTRKLSVDLPGHKDEVY 490 Query: 404 SILWSPHYKELISGHGFAQNQLVIW 428 ++ WS K + S G + +W Sbjct: 491 TVDWSVDGKRVCS--GGKDKMVRLW 513 Score = 108 bits (269), Expect = 6e-24, Method: Composition-based stats. Identities = 31/148 (20%), Positives = 58/148 (39%), Gaps = 13/148 (8%) Query: 351 FTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSP 409 H + A+ P S+ + TG G D RIW+ + + + H V + WSP Sbjct: 139 IAGHGSTILCSAFAPHTSSRMVTGAG--DNTARIWDCDTQTPMHTLKGHYNWVLCVSWSP 196 Query: 410 HYKELISGHGFAQNQLVIWKYPTMAKVAE-LKGHTSRVLSLTMSP-------DGATVASA 461 + + G N + +W + + + L+GH+ + SL+ P +AS+ Sbjct: 197 DGE--VIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASS 254 Query: 462 AADETLRLWRCFELDPARRREREKASAA 489 + D T+++W S + Sbjct: 255 SKDGTIKIWDTVSRVCQYTMSGHTNSVS 282 >6F3T-A nrPDB Length = 608 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 74/313 (23%), Positives = 132/313 (42%), Gaps = 28/313 (8%) Query: 187 LNLVDWSSGN-VLAVAL-DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVG 244 L VD + + ++A D++V +WS + + SV + + + Sbjct: 281 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLR-------------SVKQASDLSLIDKE 327 Query: 245 TSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHV 302 + ++ D + L+ + HS V S++ L S S G + ++ V Sbjct: 328 SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLV 387 Query: 303 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 GH+ V +++P G + SGG+D + +W + PL+ F H V Sbjct: 388 G-YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLW----ATDHYQPLRIFAGHLADVNCTR 442 Query: 363 WCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHGFA 421 + P + V G++DR +R+W+V +G C+ H + S+ +SP+ + L G Sbjct: 443 FHPNSNYV---ATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFL--ATGAT 497 Query: 422 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRR 481 ++++W V ELKGHT V SL S DG +AS + D T+RLW + Sbjct: 498 DGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET 557 Query: 482 EREKASAAKSSLI 494 + + +L Sbjct: 558 DDFTTATGHINLP 570 Score = 172 bits (436), Expect = 3e-43, Method: Composition-based stats. Identities = 56/282 (19%), Positives = 98/282 (34%), Gaps = 20/282 (7%) Query: 217 LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW 276 + + +++V + + +A G + + V++W V +K V S Sbjct: 269 ICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKL--------RSVKQAS- 319 Query: 277 NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 336 + ++ S D + A + L GHS V G ++PD +L S D V +W Sbjct: 320 DLSLIDKESDDVLERIMDEKTAS-ELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLW 378 Query: 337 PSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV 396 + L + H V + P+ ++ G DR R+W L Sbjct: 379 SLQT----FTCLVGYKGHNYPVWDTQFSPYGYYFVS---GGHDRVARLWATDHYQPLRIF 431 Query: 397 DAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDG 455 H + V + P+ + G A + +W V GH + SLT SP+G Sbjct: 432 AGHLADVNCTRFHPNSNYV--ATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNG 489 Query: 456 ATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 +A+ A D + LW + + G Sbjct: 490 RFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDG 531 Score = 66.3 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 29/162 (17%), Positives = 49/162 (30%), Gaps = 19/162 (11%) Query: 337 PSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV 396 P + L + + AV S + GG +D +R+W+V S Sbjct: 264 DCLPSICFYTFLNAYQG----LTAVDVTDDSSLI---AGGFADSTVRVWSVTPKKLRSVK 316 Query: 397 DAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA 456 A + I T +++ L GH+ V + SPD Sbjct: 317 QA------------SDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRN 364 Query: 457 TVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGI 498 + S++ D T+RLW + + G Sbjct: 365 YLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 406 >6EOJ-D nrPDB Length = 470 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 66/337 (19%), Positives = 135/337 (40%), Gaps = 19/337 (5%) Query: 150 VLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVALDNSVY- 207 Y+ P ++ + + +LP + + + + + W+ G L VA + + Sbjct: 59 TSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFS 118 Query: 208 LWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW--DVQQQKRLRNMT 265 LW+ASS L+Q ++++ + + +++ G + +++W + K + Sbjct: 119 LWNASSFTFETLMQ--AHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAH 176 Query: 266 SHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLA 325 + S R + S N + S + + + LSGH +V W P+ +A Sbjct: 177 TESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE-RVLSGHHWDVKSCDWHPEMGLIA 235 Query: 326 SGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW 385 S DNLV +W G + + + + V + P + N+L + D+ R++ Sbjct: 236 SASKDNLVKLWDPRSGN----CISSILKFKHTVLKTRFQPTKGNLLM--AISKDKSCRVF 289 Query: 386 NVC-SGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKY---PTMAKVAELKG 441 ++ S L V + ++ W P + + + + L + + Sbjct: 290 DIRYSMKELMCVRDETDYMTLEWHPINESMFTLACY-DGSLKHFDLLQNLNEPILTIPYA 348 Query: 442 HTSRVLSLTMSPDGATVASAAADETLRLW-RCFELDP 477 H + SL+ +P G A+AA D T+R W R +DP Sbjct: 349 HDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDP 385 Score = 94.5 bits (233), Expect = 1e-19, Method: Composition-based stats. Identities = 33/173 (19%), Positives = 66/173 (38%), Gaps = 10/173 (5%) Query: 309 SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS 368 + ++W P+GR L ++W ++ + H AV + + Sbjct: 93 KHVIPAIQWTPEGRRLVVATYSGEFSLWNASS----FTFETLMQAHDSAVTTMKYSHDSD 148 Query: 369 NVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVI 427 +++ G +D I+IW AH++ + + +S + + ++ N L I Sbjct: 149 WMIS---GDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSD--DNILKI 203 Query: 428 WKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 W + + L GH V S P+ +ASA+ D ++LW + Sbjct: 204 WNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISS 256 Score = 69.4 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 27/132 (20%), Positives = 51/132 (38%), Gaps = 8/132 (6%) Query: 355 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKE 413 + + A+ W P ++ T +WN S + + AH V ++ +S Sbjct: 93 KHVIPAIQWTPEGRRLV---VATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDW 149 Query: 414 LISGHGFAQNQLVIWKYPTMAKVAELKG-HTSRVLSLTMSPDGATVASAAADETLRLWRC 472 +IS G A + IW+ P + V E+ HT + + S + + + + D L++W Sbjct: 150 MIS--GDADGMIKIWQ-PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNF 206 Query: 473 FELDPARRRERE 484 R Sbjct: 207 SNGKQERVLSGH 218 >5UZ7-B nrPDB Length = 351 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 62/363 (17%), Positives = 138/363 (38%), Gaps = 28/363 (7%) Query: 117 ALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRIL 176 +L + D + +L + ++A + + + P + Sbjct: 9 SLLQSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRT------- 61 Query: 177 DAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK 236 Y S +++ + D + +W + + + + + + ++ + A+ Sbjct: 62 -LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR--SSWVMTCAYAP 118 Query: 237 EGNYLAVGTSSAEVQLWDVQQQK----RLRNMTSHSARVGSLSW-NSYILSSGSRSGHIH 291 GNY+A G +++++ ++ R + H+ + + + + + S Sbjct: 119 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCA 178 Query: 292 HHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTF 351 D+ + H+ +V L APD R SG D +W G + QTF Sbjct: 179 LWDIETGQQTTTFTG-HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG----MCRQTF 233 Query: 352 TQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVC---SILWS 408 T H+ + A+ + P + A G+ D R++++ + L + +C S+ +S Sbjct: 234 TGHESDINAICFFPNGN---AFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFS 290 Query: 409 PHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLR 468 + L++ G+ +W + L GH +RV L ++ DG VA+ + D L+ Sbjct: 291 KSGRLLLA--GYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLK 348 Query: 469 LWR 471 +W Sbjct: 349 IWN 351 Score = 154 bits (389), Expect = 7e-38, Method: Composition-based stats. Identities = 42/293 (14%), Positives = 101/293 (34%), Gaps = 20/293 (6%) Query: 215 DILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSL 274 + + I ++ W + L + ++ +WD ++ + S+ V + Sbjct: 55 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 114 Query: 275 SW--NSYILSSGSRSGHIHHHDVRVAEHHVAT---LSGHSQEVCGLRWAPDGRHLASGGN 329 ++ + ++ G ++++ E +V L+GH+ + R+ D + + Sbjct: 115 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-DDNQIVTSSG 173 Query: 330 DNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS 389 D +W G+ H G V +++ P ++ G D ++W+V Sbjct: 174 DTTCALWDIETGQQTTTFTG----HTGDVMSLSLAPDTRLFVS---GACDASAKLWDVRE 226 Query: 390 GACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRV-- 446 G C H S + +I + P+ G ++ ++ H + + Sbjct: 227 GMCRQTFTGHESDINAICFFPNGN--AFATGSDDATCRLFDLRADQELMT-YSHDNIICG 283 Query: 447 -LSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGI 498 S++ S G + + D +W + D A + + G+ Sbjct: 284 ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGM 336 >6N9G-C nrPDB Length = 353 Score = 227 bits (578), Expect = 1e-59, Method: Composition-based stats. Identities = 65/297 (21%), Positives = 127/297 (42%), Gaps = 27/297 (9%) Query: 189 LVDWSSG--NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTS 246 +DW +++ + D V +W + + + + M P ++ + A+ G +A G Sbjct: 68 CMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTM--PCTWVMACAYAPSGCAIACGGL 125 Query: 247 SAEVQLWDVQQQKR------LRNMTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVA 298 + ++ + K +++ H+ + + S+ + + + S G DV Sbjct: 126 DNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESG 185 Query: 299 EHHVATLSGHSQEVCGLRWAPD--GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG 356 + + + GH +V L AP G SGG D VW G+ +Q F H+ Sbjct: 186 QL-LQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQ----CVQAFETHES 240 Query: 357 AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV---CSILWSPHYKE 413 V +V + P A G+ D R++++ + ++ S + S+ +S + Sbjct: 241 DVNSVRYYPSGD---AFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRL 297 Query: 414 LISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 L + G+ + +W ++V+ L GH +RV +L +SPDG S + D TLR+W Sbjct: 298 LFA--GYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 148 bits (374), Expect = 4e-36, Method: Composition-based stats. Identities = 56/243 (23%), Positives = 92/243 (37%), Gaps = 16/243 (6%) Query: 259 KRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLR 316 K R + H +V + W + + S S+ G + D A + V Sbjct: 54 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCT-WVMACA 112 Query: 317 WAPDGRHLASGGNDNLVNVWPSA--PGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATG 374 +AP G +A GG DN +V+P E ++ H + A ++ +L Sbjct: 113 YAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQIL--- 169 Query: 375 GGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTM 433 + D +W+V SG L + H + V + +P G + ++W + Sbjct: 170 TASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSG 229 Query: 434 AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSL 493 V + H S V S+ P G AS + D T RL+ R +RE A +K S+ Sbjct: 230 QCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDL-------RADREVAIYSKESI 282 Query: 494 IHQ 496 I Sbjct: 283 IFG 285 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 48/236 (20%), Positives = 85/236 (36%), Gaps = 12/236 (5%) Query: 154 QKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASS 213 T ++ + N S +L + D + LW S Sbjct: 125 LDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVES 184 Query: 214 GDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGS 273 G +LQ +A + GN G + +WD++ + ++ +H + V S Sbjct: 185 GQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDVNS 244 Query: 274 LSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQ--EVCGLRWAPDGRHLASGGN 329 + + + +SGS +D+R A+ VA S S + ++ GR L +G N Sbjct: 245 VRYYPSGDAFASGSDDATCRLYDLR-ADREVAIYSKESIIFGASSVDFSLSGRLLFAGYN 303 Query: 330 DNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW 385 D +NVW G + H+ V + P + A G+ D +R+W Sbjct: 304 DYTINVWDVLKGSR----VSILFGHENRVSTLRVSPDGT---AFCSGSWDHTLRVW 352 Score = 74.8 bits (182), Expect = 7e-14, Method: Composition-based stats. Identities = 24/208 (11%), Positives = 57/208 (27%), Gaps = 56/208 (26%) Query: 341 GEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS------ 394 G+ +T H V + WC + ++++ + D + +W+ + Sbjct: 49 GQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSS---SQDGKVIVWDSFTTNKEHAVTMPC 105 Query: 395 -----------------------------AVDAHSQ--------------VCSILWSPHY 411 D + + + ++ Sbjct: 106 TWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSD 165 Query: 412 KELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP--DGATVASAAADETLRL 469 ++++ G +W + + GH + VL L ++P G T S D+ + Sbjct: 166 MQILTASG--DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMV 223 Query: 470 WRCFELDPARRREREKASAAKSSLIHQG 497 W + E ++ G Sbjct: 224 WDMRSGQCVQAFETHESDVNSVRYYPSG 251 >6QX9-4B nrPDB Length = 522 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 62/288 (21%), Positives = 111/288 (38%), Gaps = 20/288 (6%) Query: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPG------EYISSVAWIKEGNYLAVGTS 246 +S + LWS ++L L+ S+V+ + LA + Sbjct: 242 NSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAA 301 Query: 247 SAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVAT 304 V+LW + + + ++ H+ RV + W+ L + D+ E + Sbjct: 302 DGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQE-EILH 360 Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 GHS V + + DG +GG D VW G + H + + + Sbjct: 361 QEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTG----RCIMFLEGHLKEIYGINFS 416 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSP-HYKELISGHGFAQ 422 P G+ D ++W++ C+ + AH V + + P H L++G Sbjct: 417 PNG---YHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGA--YD 471 Query: 423 NQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 N IW +P + + L GH +V+ L +S DG +A+ + D T +LW Sbjct: 472 NTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 52/236 (22%), Positives = 85/236 (36%), Gaps = 21/236 (8%) Query: 274 LSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRH--------LA 325 S NS +L++ SG V + + TL GH+ V + + P LA Sbjct: 239 FSPNSKMLATACWSGLCKLWSVPD-CNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLA 297 Query: 326 SGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW 385 S D V +W E P+ H V V W P G DR R+W Sbjct: 298 SCAADGSVKLWSLDSDE----PVADIEGHTVRVARVMWHPSGR---FLGTTCYDRSWRLW 350 Query: 386 NVCSGACLSAVDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTS 444 ++ + + + HS V I + ++G G +W T + L+GH Sbjct: 351 DLEAQEEILHQEGHSMGVYDIAFHQDGS--LAGTGGLDAFGRVWDLRTGRCIMFLEGHLK 408 Query: 445 RVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKA--SAAKSSLIHQGI 498 + + SP+G +A+ + D T ++W + + + K IH Sbjct: 409 EIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNF 464 Score = 118 bits (295), Expect = 6e-27, Method: Composition-based stats. Identities = 32/180 (17%), Positives = 68/180 (37%), Gaps = 7/180 (3%) Query: 161 SRKTCRYIP-SLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQL 219 ++ R + IL Y LD +W +G + Sbjct: 343 YDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCI-- 400 Query: 220 LQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--- 276 + +E + I + + G ++A G+ ++WD++Q++ + + +H V + + Sbjct: 401 MFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPI 460 Query: 277 NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 336 + L +G+ + TL+GH +V GL + DG+ +A+ D +W Sbjct: 461 HGNFLLTGAYDNTAKIW-THPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 32.4 bits (72), Expect = 0.45, Method: Composition-based stats. Identities = 7/58 (12%), Positives = 16/58 (27%) Query: 441 GHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGI 498 G + SP+ +A+A +LW + + + + Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKST 286 >4V8M-A7 nrPDB Length = 318 Score = 221 bits (562), Expect = 6e-58, Method: Composition-based stats. Identities = 66/300 (22%), Positives = 123/300 (41%), Gaps = 28/300 (9%) Query: 193 SSGNVLAVALDNSVYLWSASSGDI-------LQLLQMEQPGEYISSVAWIKEGNYLAVGT 245 ++ V++ + D ++ W + L ++E ++S VA GN+ + Sbjct: 27 TATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSDVALSNNGNFAVSAS 86 Query: 246 SSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVA 303 ++LW++Q + H+ V S+++ ++ + SG R + +V+ H Sbjct: 87 WDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNVKGECMHTL 146 Query: 304 TLSGHSQEVCGLRWAP--DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 361 + H+ V +R++P D + SGG DNLV VW A G + H V +V Sbjct: 147 SRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATG----RLVTDLKGHTNYVTSV 202 Query: 362 AWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFA 421 P S D R+W++ G LS + A + + I +SP+ + + Sbjct: 203 TVSPDGS---LCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSPNRYWMCAA---T 256 Query: 422 QNQLVIWKYPTMAKVAEL-KGHTS------RVLSLTMSPDGATVASAAADETLRLWRCFE 474 + + I+ + EL H +S+ S DG+T+ S D +R+W E Sbjct: 257 EKGIRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWGVSE 316 Score = 177 bits (449), Expect = 1e-44, Method: Composition-based stats. Identities = 60/229 (26%), Positives = 96/229 (41%), Gaps = 24/229 (10%) Query: 264 MTSHSARVGSLS-----WNSYILSSGSRSGHIHHH----DVRVAEHH----VATLSGHSQ 310 +T H V SL+ + + S SR + D +E L GHS Sbjct: 9 LTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSA 68 Query: 311 EVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370 V + + +G S D+ + +W G+ + F H V +VA+ P + Sbjct: 69 FVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYK----FLGHTKDVLSVAFSPDNRQI 124 Query: 371 LATGGGTSDRHIRIWNVCSGACLSAVD---AHSQVCSILWSPHYKELISGHGFAQNQLVI 427 ++ G D +R+WNV G C+ + V + +SP + G N + + Sbjct: 125 VS---GGRDNALRVWNV-KGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKV 180 Query: 428 WKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELD 476 W T V +LKGHT+ V S+T+SPDG+ AS+ D RLW + + Sbjct: 181 WDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGE 229 Score = 144 bits (363), Expect = 9e-35, Method: Composition-based stats. Identities = 57/296 (19%), Positives = 113/296 (38%), Gaps = 33/296 (11%) Query: 147 RLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSV 206 R K L S P C Y LPDR L+ + + ++ + D+S+ Sbjct: 36 RDKTLLSWGPNPDRHSSECSY--GLPDRRLE--GHSAFVSDVALSNNGNFAVSASWDHSL 91 Query: 207 YLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMT- 265 LW+ +G + + + SVA+ + + G +++W+V + + + ++ Sbjct: 92 RLWNLQNGQCQ--YKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNV-KGECMHTLSR 148 Query: 266 -SHSARVGSLSWNSYI----LSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD 320 +H+ V + ++ + + SG + D+ V L GH+ V + +PD Sbjct: 149 GAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRL-VTDLKGHTNYVTSVTVSPD 207 Query: 321 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDR 380 G AS D + +W GE + + + P + + A +++ Sbjct: 208 GSLCASSDKDGVARLWDLTKGEALSEMAAG-----APINQICFSPNRYWMCA----ATEK 258 Query: 381 HIRIWNVCSGACLSAVDAHSQ--------VCSILWSPHYKELISGHGFAQNQLVIW 428 IRI+++ + + + Q SI WS L S G+ N + +W Sbjct: 259 GIRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYS--GYTDNVIRVW 312 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 42/210 (20%), Positives = 73/210 (34%), Gaps = 19/210 (9%) Query: 301 HVATLSGHSQEVCGLRW--APDGRH-LASGGNDNLVNVW----PSAPGEGGW-VPLQTFT 352 + L+GH V L P+ + S D + W E + +P + Sbjct: 5 YEGQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLE 64 Query: 353 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHY 411 H V VA + + D +R+WN+ +G C H+ V S+ +SP Sbjct: 65 GHSAFVSDVALSNNGN---FAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDN 121 Query: 412 KELISGHGFAQNQLVIWKYPTMAKVAELK--GHTSRVLSLTMSP--DGATVASAAADETL 467 ++++S G N L +W + L HT V + SP D + S D + Sbjct: 122 RQIVS--GGRDNALRVWNV-KGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLV 178 Query: 468 RLWRCFELDPARRREREKASAAKSSLIHQG 497 ++W + ++ G Sbjct: 179 KVWDLATGRLVTDLKGHTNYVTSVTVSPDG 208 >6MZM-G nrPDB Length = 800 Score = 221 bits (562), Expect = 7e-58, Method: Composition-based stats. Identities = 62/236 (26%), Positives = 104/236 (44%), Gaps = 13/236 (5%) Query: 262 RNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP 319 + + HS V S++ L S S G + ++ V GH+ V +++P Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG-YKGHNYPVWDTQFSP 595 Query: 320 DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSD 379 G + SGG+D + +W + PL+ F H V + P + V G++D Sbjct: 596 YGYYFVSGGHDRVARLW----ATDHYQPLRIFAGHLADVNCTRFHPNSNYV---ATGSAD 648 Query: 380 RHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAE 438 R +R+W+V +G C+ H + S+ +SP+ + L G ++++W V E Sbjct: 649 RTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFL--ATGATDGRVLLWDIGHGLMVGE 706 Query: 439 LKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLI 494 LKGHT V SL S DG +AS + D T+RLW + + + +L Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLP 762 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 50/234 (21%), Positives = 93/234 (39%), Gaps = 13/234 (5%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256 +L+ + D +V LWS + L+ + + + G Y G +LW Sbjct: 558 LLSSSEDGTVRLWSLQTFTC--LVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATD 615 Query: 257 QQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCG 314 + LR H A V + NS +++GS + DV + V +GH + Sbjct: 616 HYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNG-NCVRIFTGHKGPIHS 674 Query: 315 LRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATG 374 L ++P+GR LA+G D V +W G + + H V ++ + + Sbjct: 675 LTFSPNGRFLATGATDGRVLLWDI----GHGLMVGELKGHTDTVCSLRFSRDGEIL---A 727 Query: 375 GGTSDRHIRIWN-VCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVI 427 G+ D +R+W+ + + L D + I + +EL+ G ++ V+ Sbjct: 728 SGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVV 781 Score = 173 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 42/211 (19%), Positives = 82/211 (38%), Gaps = 13/211 (6%) Query: 222 MEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS--Y 279 + + ++ + NYL + V+LW +Q L H+ V ++ Y Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598 Query: 280 ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSA 339 SG + +GH +V R+ P+ ++A+G D V +W Sbjct: 599 YFVSGGHDRVARLWATDH-YQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVL 657 Query: 340 PGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH 399 G ++ FT H+G + ++ + P G +D + +W++ G + + H Sbjct: 658 NGN----CVRIFTGHKGPIHSLTFSPNGR---FLATGATDGRVLLWDIGHGLMVGELKGH 710 Query: 400 SQ-VCSILWSPHYKELISGHGFAQNQLVIWK 429 + VCS+ +S + I G N + +W Sbjct: 711 TDTVCSLRFSRDGE--ILASGSMDNTVRLWD 739 Score = 154 bits (389), Expect = 8e-38, Method: Composition-based stats. Identities = 44/196 (22%), Positives = 68/196 (34%), Gaps = 10/196 (5%) Query: 303 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 L GHS V G ++PD +L S D V +W + L + H V Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT----FTCLVGYKGHNYPVWDTQ 592 Query: 363 WCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFA 421 + P+ ++ G DR R+W L H + V + P+ + G A Sbjct: 593 FSPYGYYFVS---GGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYV--ATGSA 647 Query: 422 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRR 481 + +W V GH + SLT SP+G +A+ A D + LW Sbjct: 648 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707 Query: 482 EREKASAAKSSLIHQG 497 + + G Sbjct: 708 KGHTDTVCSLRFSRDG 723 Score = 102 bits (253), Expect = 5e-22, Method: Composition-based stats. Identities = 31/141 (21%), Positives = 54/141 (38%), Gaps = 5/141 (3%) Query: 157 TPGSSRKTCRYIPSLPDRILDA-PEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGD 215 G + R + + L D +S V + D +V LW +G+ Sbjct: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660 Query: 216 ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS 275 +++ I S+ + G +LA G + V LWD+ + + H+ V SL Sbjct: 661 CVRIFT--GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLR 718 Query: 276 W--NSYILSSGSRSGHIHHHD 294 + + IL+SGS + D Sbjct: 719 FSRDGEILASGSMDNTVRLWD 739 Score = 52.1 bits (123), Expect = 5e-07, Method: Composition-based stats. Identities = 14/62 (22%), Positives = 22/62 (35%) Query: 437 AELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQ 496 L GH+ V + SPD + S++ D T+RLW + + Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596 Query: 497 GI 498 G Sbjct: 597 GY 598 >6HQA-B nrPDB Length = 722 Score = 220 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 82/434 (18%), Positives = 161/434 (37%), Gaps = 59/434 (13%) Query: 85 AAQMEVASFLLSKENQPENSQTPTKKEHQK-AWALNLNGFDVEEAKILRLSGKPQNAPEG 143 Q E++S + + + E+ K A + E+A ++S E Sbjct: 269 GEQREISSVDAFNKKPVKLGKLQVDPEYSKELEAELKLKDEHEQAAQKKVSTTLL---EE 325 Query: 144 YQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALD 203 Y+ KV S + P +LP + A ++RND + + S + A Sbjct: 326 YRENFKVDPSDENNPSK--------DTLPLPLKSAQDLRNDIAM--IQDSRAKIKLSAAQ 375 Query: 204 NSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQ----- 258 S+ + + ++ + + + +A G + ++LW + Sbjct: 376 ASL--------PSVCMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSL 427 Query: 259 ----------------KRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEH 300 K R + HS V + + ++ L S S + + Sbjct: 428 LKNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDT-YT 486 Query: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 360 + + GHS V ++++P G + A+ +D +W PL+ F H V Sbjct: 487 CLVSYKGHSSSVWDVKFSPMGHYFATASHDQTARLWSCD----HIYPLRIFAGHLNDVDC 542 Query: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHG 419 V + P + + G+SD+ R+W++ G C+ HS + + SP + L S Sbjct: 543 VEFHPNSTYLF---TGSSDKTARMWDIARGECVRVFMGHSGAINCLAVSPDGRWLASAG- 598 Query: 420 FAQNQLVIWKYPTMAKVAELKGH-TSRVLSLTMSPDGATVASAAADETLRLWRCFE--LD 476 + + +W T ++ ++GH S + SL S +G + S AD ++R+W + Sbjct: 599 -EDSVVCLWDISTGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVKKNTNS 657 Query: 477 PARRREREKASAAK 490 P+ + E A+ Sbjct: 658 PSAQPEPINDVTAQ 671 Score = 186 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 70/313 (22%), Positives = 122/313 (38%), Gaps = 34/313 (10%) Query: 84 SAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEG 143 SAAQ + S + + N T K + +GF K+ + G P + Sbjct: 372 SAAQASLPSVCMYTFHNTNNDLTCLKFNDDS--TMVASGFQDSFIKLWSIDGSPLRSLLK 429 Query: 144 YQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGN--VLAVA 201 Y+Q+ G + K R + + VD+S N +++ + Sbjct: 430 NDP-----YNQQNNDGVAVKGSRRLVGHSGAVYG------------VDFSPDNRYLISCS 472 Query: 202 LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRL 261 D +V LWS + L+ + + V + G+Y A + +LW L Sbjct: 473 EDKTVRLWSLDTYTC--LVSYKGHSSSVWDVKFSPMGHYFATASHDQTARLWSCDHIYPL 530 Query: 262 RNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP 319 R H V + + NS L +GS D+ E V GHS + L +P Sbjct: 531 RIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGE-CVRVFMGHSGAINCLAVSP 589 Query: 320 DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQH-QGAVKAVAWCPWQSNVLATGGGTS 378 DGR LAS G D++V +W + G ++ H + ++ ++A+ + +++TG Sbjct: 590 DGRWLASAGEDSVVCLWDISTGRR----IKAMRGHGRSSIYSLAFSREGTVLVSTGA--- 642 Query: 379 DRHIRIWNVCSGA 391 D +R+W+V Sbjct: 643 DNSVRVWDVKKNT 655 Score = 128 bits (322), Expect = 5e-30, Method: Composition-based stats. Identities = 37/218 (16%), Positives = 80/218 (36%), Gaps = 23/218 (10%) Query: 298 AEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW----------------PSAPG 341 + T + ++ L++ D +ASG D+ + +W Sbjct: 379 PSVCMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNN 438 Query: 342 EGGWVP-LQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS 400 +G V + H GAV V + P +++ + D+ +R+W++ + CL + HS Sbjct: 439 DGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISC---SEDKTVRLWSLDTYTCLVSYKGHS 495 Query: 401 Q-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVA 459 V + +SP + +W + + GH + V + P+ + Sbjct: 496 SSVWDVKFSPMGHYFATAS--HDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLF 553 Query: 460 SAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 + ++D+T R+W + R + ++ G Sbjct: 554 TGSSDKTARMWDIARGECVRVFMGHSGAINCLAVSPDG 591 >5OPT-p nrPDB Length = 318 Score = 217 bits (553), Expect = 7e-57, Method: Composition-based stats. Identities = 63/295 (21%), Positives = 119/295 (40%), Gaps = 28/295 (9%) Query: 198 LAVALDNSVYLWSASSGDILQLLQ-------MEQPGEYISSVAWIKEGNYLAVGTSSAEV 250 ++ + DN++ W ++ + + +E ++S VA G++ + + Sbjct: 32 VSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALSNNGDFAVSASWDHSL 91 Query: 251 QLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGH 308 +LW++Q H+ V S+++ ++ + SG R + +V+ H H Sbjct: 92 RLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNVKGECLHTLGRGAH 151 Query: 309 SQEVCGLRWAP--DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW 366 + V +R++P + + SGG DNLV VW A G L H + +V P Sbjct: 152 TDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASG----RLLTDLKGHTNYITSVTVSPD 207 Query: 367 QSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLV 426 S D R+W++ G LS + A + + I +SP+ + + + + Sbjct: 208 GS---LCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSPNRYWMCAA---TEKGIR 261 Query: 427 IWKYPTMAKVAELKGH-------TSRVLSLTMSPDGATVASAAADETLRLWRCFE 474 I+ + EL T +S+ S DG T+ S D +R+W E Sbjct: 262 IFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGNTLYSGYTDNVIRVWSVSE 316 Score = 174 bits (442), Expect = 6e-44, Method: Composition-based stats. Identities = 56/229 (24%), Positives = 92/229 (40%), Gaps = 24/229 (10%) Query: 264 MTSHSARVGSLS---WNSYIL--SSGSRSGHIHHH----DVRVAEHH----VATLSGHSQ 310 + H V +L+ + S SR + D E L GHS Sbjct: 9 LKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSA 68 Query: 311 EVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370 V + + +G S D+ + +W G V F H V +V + P + Sbjct: 69 FVSDVALSNNGDFAVSASWDHSLRLWNLQTG----VCQHKFLGHTKDVLSVTFSPDNRQI 124 Query: 371 LATGGGTSDRHIRIWNVCSGACLSAV---DAHSQVCSILWSPHYKELISGHGFAQNQLVI 427 ++ G D +R+WNV G CL + V + +SP + + G N + + Sbjct: 125 VS---GGRDNALRVWNV-KGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKV 180 Query: 428 WKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELD 476 W + + +LKGHT+ + S+T+SPDG+ AS+ D RLW + + Sbjct: 181 WDIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGE 229 Score = 145 bits (365), Expect = 4e-35, Method: Composition-based stats. Identities = 43/258 (16%), Positives = 99/258 (38%), Gaps = 29/258 (11%) Query: 189 LVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSA 248 + + ++ + D+S+ LW+ +G + + + SV + + + G Sbjct: 74 ALSNNGDFAVSASWDHSLRLWNLQTGVCQH--KFLGHTKDVLSVTFSPDNRQIVSGGRDN 131 Query: 249 EVQLWDVQQQKRLRNM--TSHSARVGSLSWNSY----ILSSGSRSGHIHHHDVRVAEHHV 302 +++W+V + + L + +H+ V + ++ ++ SG + D+ + Sbjct: 132 ALRVWNV-KGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRL-L 189 Query: 303 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 L GH+ + + +PDG AS D + +W GE + + Sbjct: 190 TDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAG-----APINQIC 244 Query: 363 WCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ--------VCSILWSPHYKEL 414 + P + + A +++ IRI+++ + + + +Q SI WS L Sbjct: 245 FSPNRYWMCA----ATEKGIRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGNTL 300 Query: 415 ISGHGFAQNQLVIWKYPT 432 S G+ N + +W Sbjct: 301 YS--GYTDNVIRVWSVSE 316 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 41/210 (19%), Positives = 70/210 (33%), Gaps = 19/210 (9%) Query: 301 HVATLSGHSQEVCGLRWAP-DGRHL--ASGGNDNLVNVW----PSAPGEGGW-VPLQTFT 352 + L GH V L ++ S DN + W E + P + Sbjct: 5 YEGQLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLE 64 Query: 353 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHY 411 H V VA + D +R+WN+ +G C H+ V S+ +SP Sbjct: 65 GHSAFVSDVALSNNGD---FAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDN 121 Query: 412 KELISGHGFAQNQLVIWKYPTMAKVAELK--GHTSRVLSLTMSP--DGATVASAAADETL 467 ++++S G N L +W + L HT V + SP + + S D + Sbjct: 122 RQIVS--GGRDNALRVWNV-KGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLV 178 Query: 468 RLWRCFELDPARRREREKASAAKSSLIHQG 497 ++W + ++ G Sbjct: 179 KVWDIASGRLLTDLKGHTNYITSVTVSPDG 208 >5OQL-J nrPDB Length = 912 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 72/364 (19%), Positives = 127/364 (34%), Gaps = 61/364 (16%) Query: 163 KTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVA--------LDNSVYLWSASSG 214 + R I D ILD I D + + +S ++ V+ DN+ + G Sbjct: 364 EPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFG 423 Query: 215 DILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRN----MTSHSAR 270 + LL+ + V W G+++A G+ +LW V T H Sbjct: 424 HDVALLKGHEDIVMSLDVDWS--GHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLES 481 Query: 271 VGSLSWN------------------SYILSSGSRSGHIHHHDVRVAEHHVATLS------ 306 VG+++ L SGS+ + D+ L+ Sbjct: 482 VGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRL 541 Query: 307 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW 366 H +++ L +P+G+ AS D V +W E + H+ V V + P Sbjct: 542 AHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGI----LRGHKRGVWTVRFAPL 597 Query: 367 QSNVL-----------ATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILW------- 407 + V+ G+ D+ I++WN+ C+ + HS V ++W Sbjct: 598 NTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDD 657 Query: 408 SPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETL 467 S ++ A + +W T L H R+ +L + +ASA +D + Sbjct: 658 SITKTKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTNILASAGSDSKV 717 Query: 468 RLWR 471 WR Sbjct: 718 TFWR 721 Score = 132 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 87/511 (17%), Positives = 165/511 (32%), Gaps = 107/511 (20%) Query: 84 SAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEG 143 S + V++ + SQ+ KK + + + D E A RL+ + Sbjct: 150 SGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDAD-EIASRFRLA----WGTQD 204 Query: 144 YQNRLKVLYSQKATPGSSRKTCRY---------IPSLPDRILDAPEIRNDYYLNLVDWSS 194 + R+ LY + TP + + I P++ R+ + L W Sbjct: 205 GRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKT-MTLWLWRD 263 Query: 195 GN-----------------------VLAVALDNSVYLWSASSG-DILQLLQMEQPGEYIS 230 G + + + +W ++ +I + + GE I Sbjct: 264 GIWQGTPMLRHELLESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAIL 323 Query: 231 SVAWIKEGNYLAVGTSSAEVQLWDVQQQ------------KRLRNMTSHSARVGSLSW-- 276 S + E + + + + L+ V + R ++ + L++ Sbjct: 324 SAVSLPERSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYIL 383 Query: 277 -NSYILSSGSRSGHIHHHDVRVAE----------------HHVATLSGHSQEVCGLRWAP 319 + +++ + S I V+ A+ H VA L GH V L Sbjct: 384 PDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDW 443 Query: 320 DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAW-------------CPW 366 G +ASG DN +W P + FT H +V AVA P Sbjct: 444 SGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPL 503 Query: 367 QSNVLATGGGTSDRHIRIWN----VCSGACLSA----VDAHSQVCSILWSPHYKELISGH 418 G+ DR ++ + + G L++ + + ++ SP+ K S Sbjct: 504 DHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASAS 563 Query: 419 GFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP---------DGA-----TVASAAAD 464 + IW + L+GH V ++ +P G+ V + + D Sbjct: 564 --QDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGD 621 Query: 465 ETLRLWRCFELDPARRREREKASAAKSSLIH 495 +T++LW + R E + K +H Sbjct: 622 KTIKLWNLSDYTCIRTFEGHSHNVLKVVWLH 652 Score = 85.2 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 54/339 (15%), Positives = 116/339 (34%), Gaps = 72/339 (21%) Query: 193 SSGNVLAVALDNSVYLW------SASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTS 246 S +++ + ++ ++ S + + + + +A + LA G + Sbjct: 72 SGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAA 131 Query: 247 SAEVQLWDVQQQKRLRNMTSHSARVGSLSW--------------------------NSYI 280 +++WD+ ++ S V +L + ++ Sbjct: 132 DGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADE 191 Query: 281 LSS------GSRSGHIHHHDVRVAEHHV------ATLSGHSQEVCGLRWAPDGRHLASGG 328 ++S G++ G I D+ H V + ++P+ L SG Sbjct: 192 IASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGS 251 Query: 329 NDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC 388 D + +W G P+ +++V + + + G +RIW+ Sbjct: 252 RDKTMTLWLWRDGIWQGTPMLRHE----LLESVGFLNEGKWMYSAGTS---GVLRIWDTT 304 Query: 389 SGACL-SAVDAHSQVCSIL--WSPHYKELISGHGFAQNQLVIWKYPTMAKVAE------- 438 + + DA S+ +IL S + LI A LV+++ P+ A V Sbjct: 305 THHEITKKQDAKSEGEAILSAVSLPERSLILCA-QADFTLVLYRVPSPADVVSSSEGILL 363 Query: 439 -----LKGHTSRVLSLTMS-PDGAT--VASAAADETLRL 469 + G +L LT PD + +A+ + D +R+ Sbjct: 364 EPFRRISGTHDEILDLTYILPDQSMMAIATNSED--IRI 400 Score = 31.7 bits (70), Expect = 0.83, Method: Composition-based stats. Identities = 12/59 (20%), Positives = 30/59 (50%), Gaps = 1/59 (1%) Query: 415 ISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 I +N ++ + T ++AE++G + +LT++P G+ + + T+R++ Sbjct: 34 ILASTLGENAILT-ELNTGKRLAEIQGDGEPISTLTITPSGSHLIVCSRSLTMRIYSLA 91 >5WYK-BB nrPDB Length = 943 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 69/360 (19%), Positives = 139/360 (38%), Gaps = 39/360 (10%) Query: 132 RLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVD 191 +S + YS + P + + +D Sbjct: 345 TVSSSKLELVLTTSSNTIEYYSIP------YEKRDPTSPAPLKTHTIELQGQRTDVRSID 398 Query: 192 WSSGN-VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEV 250 S N +LA A + S+ +W+ + ++ + Y + ++ G + +GT + E+ Sbjct: 399 ISDDNKLLATASNGSLKIWNIKTHKCIRTFEC----GYALTCKFLPGGLLVILGTRNGEL 454 Query: 251 QLWDVQQQKRLRNMT-SHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAE-------- 299 QL+D+ L + +H A + SL + L +GS + D +V Sbjct: 455 QLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKN 514 Query: 300 HHVATLSGH-------SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFT 352 + L H + ++ +R +PD R+LA DN V V+ + + Sbjct: 515 KFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLDSMK----FYLSLY 570 Query: 353 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHY 411 H+ V ++ + S ++ T ++D++I+IW + G C ++ AH + ++ + P Sbjct: 571 GHKLPVLSIDIS-FDSKMIITS--SADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQS 627 Query: 412 KELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 S + W + +L H S V +L ++ DG V S++ D ++R+W Sbjct: 628 HNFFSCS--KDAVVKYWDGEKFECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWE 685 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 47/341 (13%), Positives = 109/341 (31%), Gaps = 32/341 (9%) Query: 172 PDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGD---------ILQLLQM 222 P + + + V S ++ N++ +S +++ Sbjct: 328 PFQTIRSLYKIKSASWTTVSSSKLELVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIEL 387 Query: 223 EQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYI 280 + + S+ + LA + + +++W+++ K +R + + + Sbjct: 388 QGQRTDVRSIDISDDNKLLATAS-NGSLKIWNIKTHKCIRTFE--CGYALTCKFLPGGLL 444 Query: 281 LSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP--- 337 + G+R+G + D+ + H + L DG+ L +G D V W Sbjct: 445 VILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKV 504 Query: 338 ---SAPGEGGWVPLQTFTQH------QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC 388 PG H + V P + + D ++++ + Sbjct: 505 ENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISL---LDNTVKVFFLD 561 Query: 389 SGACLSAVDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVL 447 S ++ H V SI S K +I+ A + IW L H ++ Sbjct: 562 SMKFYLSLYGHKLPVLSIDISFDSKMIITSS--ADKNIKIWGLDFGDCHKSLFAHQDSIM 619 Query: 448 SLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASA 488 ++ P S + D ++ W + + ++ ++ Sbjct: 620 NVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEV 660 Score = 112 bits (279), Expect = 5e-25, Method: Composition-based stats. Identities = 46/208 (22%), Positives = 83/208 (39%), Gaps = 24/208 (11%) Query: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPG----------EYISSVAWIKEGNYLA 242 G ++ AL++ V +W +GD++ L P + + K+ + LA Sbjct: 37 GPGQLITSALED-VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLA 95 Query: 243 VGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEH 300 VG + +++WD+ + L N H A + L ++ L SGS+ +I D+ V E Sbjct: 96 VGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDL-VGEV 154 Query: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 360 + L H + G W L S D ++ +W ++T H G Sbjct: 155 GLYKLRSHKDSITGF-WCQGEDWLISTSKDGMIKLWDL----KTHQCIETHIAHTGECWG 209 Query: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVC 388 +A ++ TG D ++IW + Sbjct: 210 LAV--KDDLLITTGT---DSQVKIWKLD 232 Score = 111 bits (277), Expect = 7e-25, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 76/239 (31%), Gaps = 44/239 (18%) Query: 235 IKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHD 294 G + V +WD++ + ++ S D Sbjct: 36 SGPGQLITSALED--VNIWDIKTGDLVSKLSDGLPPGAS--------------------D 73 Query: 295 VRVAEHHVAT-LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ 353 R A+ T L H D LA G D ++ VW L F Sbjct: 74 ARGAKPAECTYLEAHK----------DTDLLAVGYADGVIKVWDLMSKTV----LLNFNG 119 Query: 354 HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKE 413 H+ A+ + + + +++ G+ D +I +W++ L + +H + W Sbjct: 120 HKAAITLLQFDGTGTRLIS---GSKDSNIIVWDLVGEVGLYKLRSHKDSITGFWCQGEDW 176 Query: 414 LISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 LIS + +W T + HT L + D + + D +++W+ Sbjct: 177 LISTS--KDGMIKLWDLKTHQCIETHIAHTGECWGLAVKDD--LLITTGTDSQVKIWKL 231 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 68/437 (15%), Positives = 134/437 (30%), Gaps = 74/437 (16%) Query: 110 KEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKA---TPGSSRKTCR 166 K +Q+ G A + + N+ +L + + + Sbjct: 3 KSYQRFEQAAAFGVIASNANCVWIPASSGNSNGSGPGQLITSALEDVNIWDIKTGDLVSK 62 Query: 167 YIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVAL-DNSVYLWSASSGDILQLLQMEQP 225 LP DA + L ++LAV D + +W S + LL Sbjct: 63 LSDGLPPGASDARGAKPAECTYLEAHKDTDLLAVGYADGVIKVWDLMSKTV--LLNFNGH 120 Query: 226 GEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSL-SWNSYILSSG 284 I+ + + G L G+ + + +WD+ + L + SH + L S Sbjct: 121 KAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYKLRSHKDSITGFWCQGEDWLIST 180 Query: 285 SRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS----AP 340 S+ G I D++ + T H+ E GL L + G D+ V +W Sbjct: 181 SKDGMIKLWDLKT-HQCIETHIAHTGECWGLAV--KDDLLITTGTDSQVKIWKLDIENDK 237 Query: 341 GEGGWVPLQTFTQHQGA----VKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACL--- 393 G + F + ++ + +++ D+ I + + + Sbjct: 238 MGGKLTEMGIFEKQSKQRGLKIEFITNSSDKTSFFYIQNA--DKTIETFRIRKEEEIARG 295 Query: 394 ----------------------------------SAVDAHSQVCSILW---SPHYKELIS 416 + + ++ S W S EL+ Sbjct: 296 LKKREKRLKEKGLTEEEIAKSIKESYSSFILHPFQTIRSLYKIKSASWTTVSSSKLELVL 355 Query: 417 GHGFAQNQLVIWKYPTMAK-----------VAELKGHTSRVLSLTMSPDGATVASAAADE 465 + N + + P + EL+G + V S+ +S D +A+A+ + Sbjct: 356 TT--SSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRTDVRSIDISDDNKLLATAS-NG 412 Query: 466 TLRLWRCFELDPARRRE 482 +L++W R E Sbjct: 413 SLKIWNIKTHKCIRTFE 429 Score = 105 bits (262), Expect = 4e-23, Method: Composition-based stats. Identities = 35/257 (13%), Positives = 89/257 (34%), Gaps = 31/257 (12%) Query: 259 KRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLR 316 + V S+ ++ +L++ S +G + +++ + T + Sbjct: 382 THTIELQGQRTDVRSIDISDDNKLLATAS-NGSLKIWNIKT-HKCIRTFE--CGYALTCK 437 Query: 317 WAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGG 376 + P G + G + + ++ A H A+ ++ ++ G Sbjct: 438 FLPGGLLVILGTRNGELQLFDLASSSLLDTIE---DAHDAAIWSLDLTSDGKRLV---TG 491 Query: 377 TSDRHIRIWN-----------------VCSGACLSAVDAHSQVCSILWSPHYKELISGHG 419 ++D+ ++ W+ V + ++ + + SP + L Sbjct: 492 SADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYL--AIS 549 Query: 420 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPAR 479 N + ++ +M L GH VLS+ +S D + +++AD+ +++W D + Sbjct: 550 LLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHK 609 Query: 480 RREREKASAAKSSLIHQ 496 + S + Q Sbjct: 610 SLFAHQDSIMNVKFLPQ 626 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 16/88 (18%), Positives = 25/88 (28%), Gaps = 12/88 (13%) Query: 424 QLVIWKYPTMAKVAEL-----KGHTS-------RVLSLTMSPDGATVASAAADETLRLWR 471 + IW T V++L G + L D +A AD +++W Sbjct: 48 DVNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAVGYADGVIKVWD 107 Query: 472 CFELDPARRREREKASAAKSSLIHQGIR 499 KA+ G R Sbjct: 108 LMSKTVLLNFNGHKAAITLLQFDGTGTR 135 >6QX9-5O nrPDB Length = 357 Score = 215 bits (546), Expect = 5e-56, Method: Composition-based stats. Identities = 57/313 (18%), Positives = 119/313 (38%), Gaps = 24/313 (7%) Query: 167 YIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPG 226 SL I+ + Y + + + D + LW+ GD ++ Sbjct: 51 RCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHS 109 Query: 227 EYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSL---SWNSYILSS 283 + + + +G+ L ++ V +WD + +R++ + H++ V S ++ + Sbjct: 110 GAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCT 169 Query: 284 GSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEG 343 GS G + D+R + + T + +V + + + SGG DN + VW + Sbjct: 170 GSDDGTVKLWDIRK-KAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKL 227 Query: 344 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC----SGACLSAVDA- 398 + T H +V ++ S +L+ D +R+W+V C+ Sbjct: 228 TY----TMRGHADSVTGLSLSSEGSYLLSNA---MDNTVRVWDVRPFAPKERCVKIFQGN 280 Query: 399 ----HSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPD 454 + WSP ++ G A + +W + + +L GH + + PD Sbjct: 281 VHNFEKNLLRCSWSPDGSKI--AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPD 338 Query: 455 GATVASAAADETL 467 + SA++D+ L Sbjct: 339 EPIIISASSDKRL 351 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 54/223 (24%), Positives = 90/223 (40%), Gaps = 10/223 (4%) Query: 260 RLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRW 317 + ++ H V + N L+S I +V + ATL GHS V L + Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY 117 Query: 318 APDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGT 377 DG L S D V VW S GE ++ H V + P + G+ Sbjct: 118 NTDGSMLFSASTDKTVAVWDSETGER----VKRLKGHTSFVNS--CYPARRGPQLVCTGS 171 Query: 378 SDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVA 437 D +++W++ A + QV ++ ++ ++IS G N + +W Sbjct: 172 DDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIIS--GGIDNDIKVWDLRQNKLTY 229 Query: 438 ELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 ++GH V L++S +G+ + S A D T+R+W P R Sbjct: 230 TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKER 272 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 50/240 (20%), Positives = 109/240 (45%), Gaps = 19/240 (7%) Query: 196 NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEG-NYLAVGTSSAEVQLWD 254 + + + D +V +W + +G ++ +++ +++S + G + G+ V+LWD Sbjct: 123 MLFSASTDKTVAVWDSETG--ERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180 Query: 255 VQQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEV 312 ++++ ++ + + +V ++++N S + SG I D+R T+ GH+ V Sbjct: 181 IRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWDLR-QNKLTYTMRGHADSV 238 Query: 313 CGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ--H---QGAVKAVAWCPWQ 367 GL + +G +L S DN V VW P ++ F H + ++ +W P Sbjct: 239 TGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRC-SWSPDG 297 Query: 368 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLV 426 S + G++DR + +W+ S L + H+ + + + P +IS + +L Sbjct: 298 SKI---AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISAS--SDKRLY 352 Score = 138 bits (348), Expect = 4e-33, Method: Composition-based stats. Identities = 42/197 (21%), Positives = 80/197 (40%), Gaps = 9/197 (4%) Query: 302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 361 + LSGH EV ++ P+G LAS G D L+ +W + T H GAV + Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNY---ATLKGHSGAVMEL 115 Query: 362 AWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGF 420 + S + + ++D+ + +W+ +G + + H+ V S + +L+ G Sbjct: 116 HYNTDGSMLFS---ASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLV-CTGS 171 Query: 421 AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 + +W A + + T +VL++T + + S D +++W + Sbjct: 172 DDGTVKLWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYT 230 Query: 481 REREKASAAKSSLIHQG 497 S SL +G Sbjct: 231 MRGHADSVTGLSLSSEG 247 Score = 104 bits (258), Expect = 1e-22, Method: Composition-based stats. Identities = 33/193 (17%), Positives = 76/193 (39%), Gaps = 17/193 (8%) Query: 153 SQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDW--SSGNVLAVALDNSVYLWS 210 Q GS T + + +N Y + V + +S +++ +DN + +W Sbjct: 164 PQLVCTGSDDGTVKLWDI--RKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWD 221 Query: 211 ASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ----QQKRLRNMTS 266 + M + ++ ++ EG+YL V++WDV+ +++ ++ Sbjct: 222 LRQNKL--TYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQG 279 Query: 267 --H--SARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD 320 H + SW + +++GS ++ D + + L GH+ + + + PD Sbjct: 280 NVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDT-TSRRILYKLPGHAGSINEVAFHPD 338 Query: 321 GRHLASGGNDNLV 333 + S +D + Sbjct: 339 EPIIISASSDKRL 351 >3MKQ-A nrPDB Length = 814 Score = 211 bits (537), Expect = 6e-55, Method: Composition-based stats. Identities = 52/265 (19%), Positives = 97/265 (36%), Gaps = 10/265 (3%) Query: 221 QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NS 278 + + + + ++ S V++W+ + Q +R++ V + + Sbjct: 8 TFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIARK 67 Query: 279 YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 + GS I + E V H + + P ++ SG +D V +W Sbjct: 68 NWIIVGSDDFRIRVFNYNTGEK-VVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWN- 125 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 E W QTF H+ V VA+ P + A+ G DR +++W++ + Sbjct: 126 --WENNWALEQTFEGHEHFVMCVAFNPKDPSTFAS--GCLDRTVKVWSLGQSTPNFTLTT 181 Query: 399 HSQ--VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA 456 + V + + P + + IW Y T + VA L+GH S V P Sbjct: 182 GQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLP 241 Query: 457 TVASAAADETLRLWRCFELDPARRR 481 + S + D TL++W + Sbjct: 242 IIISGSEDGTLKIWNSSTYKVEKTL 266 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 52/266 (19%), Positives = 103/266 (38%), Gaps = 14/266 (5%) Query: 206 VYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMT 265 V +W+ + +++ ++ + + +I N++ VG+ +++++ +++ + Sbjct: 37 VEIWNYET--QVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFE 94 Query: 266 SHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP-DGR 322 +H + S++ + + SGS + + T GH V + + P D Sbjct: 95 AHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPS 154 Query: 323 HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHI 382 ASG D V VW G+ T T + V V + P + D I Sbjct: 155 TFASGCLDRTVKVWSL--GQSTPNFTLT-TGQERGVNYVDYYPLPDKPYMI-TASDDLTI 210 Query: 383 RIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKG 441 +IW+ + +C++ ++ H S V ++ P +ISG L IW T L Sbjct: 211 KIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGS--EDGTLKIWNSSTYKVEKTLNV 268 Query: 442 HTSRVLSLTMSPDGA--TVASAAADE 465 R + P G +AS + Sbjct: 269 GLERSWCIATHPTGRKNYIASGFDNG 294 Score = 157 bits (397), Expect = 9e-39, Method: Composition-based stats. Identities = 42/274 (15%), Positives = 97/274 (35%), Gaps = 29/274 (10%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWD-V 255 ++ + D + +++ ++G +++ E +YI S+A Y+ G+ V+LW+ Sbjct: 70 IIVGSDDFRIRVFNYNTG--EKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWE 127 Query: 256 QQQKRLRNMTSHSARVGSLSWNSY---ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEV 312 + H V +++N +SG + + + + +G + V Sbjct: 128 NNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGV 187 Query: 313 CGLRW--APDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370 + + PD ++ + +D + +W + T H V + P + Sbjct: 188 NYVDYYPLPDKPYMITASDDLTIKIWDYQTK----SCVATLEGHMSNVSFAVFHPTLPII 243 Query: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWK 429 ++ G+ D ++IWN + ++ + I P ++ GF N + Sbjct: 244 IS---GSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGF-DNGFTVLS 299 Query: 430 YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAA 463 +L++ P G V S Sbjct: 300 LGNDEP------------TLSLDPVGKLVWSGGK 321 Score = 118 bits (296), Expect = 5e-27, Method: Composition-based stats. Identities = 55/314 (17%), Positives = 106/314 (33%), Gaps = 23/314 (7%) Query: 156 ATPGSSRKTCRYIPS-LPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSG 214 GS R ++++D + V + VL+ + D +V LW+ + Sbjct: 70 IIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWEN- 128 Query: 215 DILQLLQMEQPGEYISSVAWIK-EGNYLAVGTSSAEVQLWDVQQQKRLRNM-TSHSARVG 272 + E ++ VA+ + + A G V++W + Q + T V Sbjct: 129 NWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVN 188 Query: 273 SLSW----NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGG 328 + + + + + S I D + + VATL GH V + P + SG Sbjct: 189 YVDYYPLPDKPYMITASDDLTIKIWDYQT-KSCVATLEGHMSNVSFAVFHPTLPIIISGS 247 Query: 329 NDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC 388 D + +W S+ + +T +A P G D + ++ Sbjct: 248 EDGTLKIWNSST----YKVEKTLNVGLERSWCIATHPTGRKNYIASG--FDNGFTVLSLG 301 Query: 389 SGACLSAVDAHSQVCSILWSPHYK----ELISGHGFAQNQLVIWKYPTMAKVAELKGHTS 444 + ++D V ++WS ++ + ++ P + EL Sbjct: 302 NDEPTLSLD---PVGKLVWSGGKNAAASDIFTAVIRGNEEVEQ-DEPLSLQTKELGSVDV 357 Query: 445 RVLSLTMSPDGATV 458 SL SP+G V Sbjct: 358 FPQSLAHSPNGRFV 371 Score = 114 bits (286), Expect = 6e-26, Method: Composition-based stats. Identities = 38/241 (15%), Positives = 86/241 (35%), Gaps = 16/241 (6%) Query: 262 RNMTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP 319 + ++ S RV + ++ + + SG + + + V ++ V ++ Sbjct: 7 KTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYET-QVEVRSIQVTETPVRAGKFIA 65 Query: 320 DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSD 379 + G +D + V+ GE + F H ++++A P + VL+ G+ D Sbjct: 66 RKNWIIVGSDDFRIRVFNYNTGEK----VVDFEAHPDYIRSIAVHPTKPYVLS---GSDD 118 Query: 380 RHIRIWNVCSGACL-SAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVA 437 +++WN + L + H V + ++P G + +W Sbjct: 119 LTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPS-TFASGCLDRTVKVWSLGQSTPNF 177 Query: 438 ELK-GHTSRVLSLTM--SPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLI 494 L G V + PD + +A+ D T+++W E ++ + + Sbjct: 178 TLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFH 237 Query: 495 H 495 Sbjct: 238 P 238 >5NZU-C nrPDB Length = 905 Score = 211 bits (536), Expect = 8e-55, Method: Composition-based stats. Identities = 46/253 (18%), Positives = 94/253 (37%), Gaps = 9/253 (3%) Query: 221 QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NS 278 ++ + + SV ++ + V +W+ + Q ++ V + + Sbjct: 10 KLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARK 69 Query: 279 YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 + +G+ I + E V HS + + P + + +D L+ +W Sbjct: 70 NWVVTGADDMQIRVFNYNTLER-VHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD- 127 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 + W Q F H V + P +N A+ + DR I++W + S + ++ Sbjct: 128 --WDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASA--SLDRTIKVWQLGSSSPNFTLEG 183 Query: 399 HSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGAT 457 H + V I + + G + IW Y V L+GH V + P+ Sbjct: 184 HEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPI 243 Query: 458 VASAAADETLRLW 470 + + + D T+R+W Sbjct: 244 IITGSEDGTVRIW 256 Score = 174 bits (442), Expect = 6e-44, Method: Composition-based stats. Identities = 48/275 (17%), Positives = 99/275 (36%), Gaps = 13/275 (4%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256 +LA + SV +W+ + +++ E + + ++ N++ G ++++++ Sbjct: 30 MLASLYNGSVCVWNHETQTLVKTF--EVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYN 87 Query: 257 QQKRLRNMTSHSARVGSLSWNSYI--LSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCG 314 +R+ +HS + ++ + + + S I D GH+ V Sbjct: 88 TLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQ 147 Query: 315 LRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLAT 373 + P D AS D + VW G P T H+ V + + Sbjct: 148 IVINPKDNNQFASASLDRTIKVWQL----GSSSPNFTLEGHEKGVNCIDYYSGGDKPYLI 203 Query: 374 GGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPT 432 G DR ++IW+ + C+ ++ H V + P +I+G + IW T Sbjct: 204 -SGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGS--EDGTVRIWHSST 260 Query: 433 MAKVAELKGHTSRVLSLTMSPDGATVASAAADETL 467 + L RV + VA + ++ Sbjct: 261 YRLESTLNYGMERVWCVASLRGSNNVALGYDEGSI 295 Score = 132 bits (331), Expect = 5e-31, Method: Composition-based stats. Identities = 49/317 (15%), Positives = 100/317 (31%), Gaps = 24/317 (7%) Query: 156 ATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGN--VLAVALDNSVYLWSASS 213 G+ R + E +D Y+ + +L + D + LW Sbjct: 72 VVTGADDMQIRVFNYNTLERVHMFEAHSD-YIRCIAVHPTQPFILTSSDDMLIKLWDWD- 129 Query: 214 GDILQLLQMEQPGEYISSVAWIK-EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVG 272 E Y+ + + N A + +++W + + H V Sbjct: 130 KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVN 189 Query: 273 SLSW----NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGG 328 + + + L SG+ + D + + V TL GH+Q V + P+ + +G Sbjct: 190 CIDYYSGGDKPYLISGADDRLVKIWDYQN-KTCVQTLEGHAQNVSCASFHPELPIIITGS 248 Query: 329 NDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC 388 D V +W S+ + T V VA +NV G + I + + Sbjct: 249 EDGTVRIWHSST----YRLESTLNYGMERVWCVASLRGSNNV---ALGYDEGSIIV-KLG 300 Query: 389 SGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQ------LVIWKYPTMAKVAELKGH 442 ++DA+ ++ S + + G + + L + + + H Sbjct: 301 REEPAMSMDANGKIIWAKHSEVQQANLKAMGDTEIKDGERLPLAVKDMGSCEIYPQTIQH 360 Query: 443 TSRVLSLTMSPDGATVA 459 + + DG + Sbjct: 361 NPNGRFVVVCGDGEYII 377 Score = 131 bits (330), Expect = 6e-31, Method: Composition-based stats. Identities = 38/241 (15%), Positives = 85/241 (35%), Gaps = 15/241 (6%) Query: 262 RNMTSHSARVGSLSWNS---YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWA 318 R +T+ S RV S+ + ++L+S +G + + V T V ++ Sbjct: 9 RKLTARSDRVKSVDLHPTEPWMLAS-LYNGSVCVWNHETQTL-VKTFEVCDLPVRAAKFV 66 Query: 319 PDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTS 378 + +G +D + V+ + F H ++ +A P Q +L + + Sbjct: 67 ARKNWVVTGADDMQIRVFNY----NTLERVHMFEAHSDYIRCIAVHPTQPFILTS---SD 119 Query: 379 DRHIRIWN-VCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVA 437 D I++W+ +C + H+ + + +W+ + + Sbjct: 120 DMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNF 179 Query: 438 ELKGHTSRVLSLTMSPDG--ATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIH 495 L+GH V + G + S A D +++W + E + + +S Sbjct: 180 TLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHP 239 Query: 496 Q 496 + Sbjct: 240 E 240 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 38/198 (19%), Positives = 74/198 (37%), Gaps = 12/198 (6%) Query: 303 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 L+ S V + P + + + V VW ++TF V+A Sbjct: 9 RKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWN----HETQTLVKTFEVCDLPVRAAK 64 Query: 363 WCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFA 421 + ++ V+ G D IR++N + + +AHS + I P +++ Sbjct: 65 FVARKNWVV---TGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSD-- 119 Query: 422 QNQLVIWKYPT-MAKVAELKGHTSRVLSLTMSP-DGATVASAAADETLRLWRCFELDPAR 479 + +W + + +GHT V+ + ++P D ASA+ D T+++W+ P Sbjct: 120 DMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNF 179 Query: 480 RREREKASAAKSSLIHQG 497 E + G Sbjct: 180 TLEGHEKGVNCIDYYSGG 197 >6J6H-n nrPDB Length = 455 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 70/386 (18%), Positives = 141/386 (36%), Gaps = 28/386 (7%) Query: 96 SKENQPENSQTPTKKEHQKAW--ALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYS 153 S + + + T+KE Q + AL + D E+ ++ +S + + YQ R + Sbjct: 73 SSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPP 132 Query: 154 QKATPGSSRKTCRYIPSLPDRIL-DAPEI-RNDYYLNLVDWSSGNVLAVALDNSVYLWSA 211 + + LP +++ + P L + + +L+ D+++ +W Sbjct: 133 NDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF 192 Query: 212 SSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMT--SHSA 269 D L + + I ++ + ++ + V++WD + K + S A Sbjct: 193 YH-DYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPA 251 Query: 270 RVGSLSWNSYILSSGSRSGHIHHHDVRVAEHH--VATLSGHSQEVCGLRWAPDGRHLASG 327 V S N + G + I H+D RV+E+ V T H + L++ PDG S Sbjct: 252 DVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISS 311 Query: 328 GNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 387 D V +W + T QH ++ + + + D I +++ Sbjct: 312 SEDKTVRIWENQINVPIKQISDT-AQH-----SMPFLNVHPSQNYFCAQSMDNRIYSFSL 365 Query: 388 ---CSGACLSAVDAHSQV---CSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK- 440 HS S+ +S + + S G ++++L W + T + +K Sbjct: 366 KPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICS--GDSKSRLFTWDWNTSRLLNNIKI 423 Query: 441 -GHTSRVLSLTMSPDG--ATVASAAA 463 G + + P + S AA Sbjct: 424 PG-NKPITQVDWHPQETSKVICSGAA 448 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 38/178 (21%), Positives = 78/178 (43%), Gaps = 11/178 (6%) Query: 298 AEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG 356 + + GH + L++ P G + SGGND+ + +W + L+ F H Sbjct: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFY---HDYECLRDFQGHNK 207 Query: 357 AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELIS 416 +KA+ + + L++ + DR ++IW+ +G + + +S + P Sbjct: 208 PIKALRFTEDCQSFLSS---SFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFI 264 Query: 417 GHGFAQNQLVIWK---YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 G + ++++ + V H S +L+L PDG+ S++ D+T+R+W Sbjct: 265 V-GLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 Score = 115 bits (287), Expect = 5e-26, Method: Composition-based stats. Identities = 44/262 (16%), Positives = 83/262 (31%), Gaps = 52/262 (19%) Query: 259 KRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGL 315 K +RN H +L + +++ SG I D + GH++ + L Sbjct: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKAL 212 Query: 316 RWAPDGRHLASGGNDNLVNVWPSAPGEGGWVP---------------------------- 347 R+ D + S D V +W + G+ Sbjct: 213 RFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKI 272 Query: 348 -------------LQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS 394 +QT+ H ++ A+ + P S +++ + D+ +RIW + Sbjct: 273 LHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISS---SEDKTVRIWENQINVPIK 329 Query: 395 AVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYP---TMAKVAELKGHTS--RVLSL 449 + +Q + H + N++ + KGH+S +SL Sbjct: 330 QISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISL 389 Query: 450 TMSPDGATVASAAADETLRLWR 471 S DG + S + L W Sbjct: 390 AFSGDGRYICSGDSKSRLFTWD 411 Score = 61.7 bits (148), Expect = 8e-10, Method: Composition-based stats. Identities = 16/93 (17%), Positives = 35/93 (37%), Gaps = 3/93 (3%) Query: 391 ACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWK-YPTMAKVAELKGHTSRVLS 448 + H ++ + P LI G + + IW Y + + +GH + + Sbjct: 153 KVIRNYPGHPEGTTALKFLPKTGHLIL-SGGNDHTIKIWDFYHDYECLRDFQGHNKPIKA 211 Query: 449 LTMSPDGATVASAAADETLRLWRCFELDPARRR 481 L + D + S++ D ++++W R Sbjct: 212 LRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRL 244 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 12/68 (17%), Positives = 22/68 (32%), Gaps = 1/68 (1%) Query: 430 YPTMAKVAELKGHTSRVLSLTMSP-DGATVASAAADETLRLWRCFELDPARRREREKASA 488 Y + GH +L P G + S D T+++W + R + Sbjct: 149 YLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKP 208 Query: 489 AKSSLIHQ 496 K+ + Sbjct: 209 IKALRFTE 216 >2YNP-A nrPDB Length = 604 Score = 207 bits (527), Expect = 9e-54, Method: Composition-based stats. Identities = 53/265 (20%), Positives = 97/265 (36%), Gaps = 10/265 (3%) Query: 221 QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NS 278 + + + + ++ S V+LW+ + Q +R++ V + + Sbjct: 8 TFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARK 67 Query: 279 YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 + GS I + E V H + + P ++ SG +D V +W Sbjct: 68 NWIIVGSDDFRIRVFNYNTGEK-VVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWN- 125 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 E W QTF H+ V VA+ P + A+ G DR +++W++ + Sbjct: 126 --WENNWALEQTFEGHEHFVMCVAFNPKDPSTFAS--GCLDRTVKVWSLGQSTPNFTLTT 181 Query: 399 HSQ--VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA 456 + V + + P + + IW Y T + VA L+GH S V P Sbjct: 182 GQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLP 241 Query: 457 TVASAAADETLRLWRCFELDPARRR 481 + S + D TL++W + Sbjct: 242 IIISGSEDGTLKIWNSSTYKVEKTL 266 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 55/275 (20%), Positives = 105/275 (38%), Gaps = 14/275 (5%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256 VL V LW+ + +++ ++ + + +I N++ VG+ +++++ Sbjct: 28 VLTTLYSGRVELWNYET--QVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFNYN 85 Query: 257 QQKRLRNMTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCG 314 +++ + +H + S++ + + SGS + + T GH V Sbjct: 86 TGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMC 145 Query: 315 LRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLAT 373 + + P D ASG D V VW G+ T T + V V + P Sbjct: 146 VAFNPKDPSTFASGCLDRTVKVWSL--GQSTPNFTLT-TGQERGVNYVDYYPLPDKPYMI 202 Query: 374 GGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPT 432 + D I+IW+ + +C++ ++ H S V ++ P +ISG L IW T Sbjct: 203 -TASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGS--EDGTLKIWNSST 259 Query: 433 MAKVAELKGHTSRVLSLTMSPDGA--TVASAAADE 465 L R + P G +AS + Sbjct: 260 YKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNG 294 Score = 154 bits (390), Expect = 6e-38, Method: Composition-based stats. Identities = 42/274 (15%), Positives = 97/274 (35%), Gaps = 29/274 (10%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWD-V 255 ++ + D + +++ ++G +++ E +YI S+A Y+ G+ V+LW+ Sbjct: 70 IIVGSDDFRIRVFNYNTG--EKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWE 127 Query: 256 QQQKRLRNMTSHSARVGSLSWNSY---ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEV 312 + H V +++N +SG + + + + +G + V Sbjct: 128 NNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGV 187 Query: 313 CGLRW--APDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370 + + PD ++ + +D + +W + T H V + P + Sbjct: 188 NYVDYYPLPDKPYMITASDDLTIKIWDYQTK----SCVATLEGHMSNVSFAVFHPTLPII 243 Query: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWK 429 ++ G+ D ++IWN + ++ + I P ++ GF N + Sbjct: 244 IS---GSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGF-DNGFTVLS 299 Query: 430 YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAA 463 +L++ P G V S Sbjct: 300 LGNDEP------------TLSLDPVGKLVWSGGK 321 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 46/264 (17%), Positives = 90/264 (34%), Gaps = 18/264 (6%) Query: 156 ATPGSSRKTCRYIPS-LPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSG 214 GS R ++++D + V + VL+ + D +V LW+ + Sbjct: 70 IIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWEN- 128 Query: 215 DILQLLQMEQPGEYISSVAWIK-EGNYLAVGTSSAEVQLWDVQQQKRLRNM-TSHSARVG 272 + E ++ VA+ + + A G V++W + Q + T V Sbjct: 129 NWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVN 188 Query: 273 SLSW----NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGG 328 + + + + + S I D + + VATL GH V + P + SG Sbjct: 189 YVDYYPLPDKPYMITASDDLTIKIWDYQT-KSCVATLEGHMSNVSFAVFHPTLPIIISGS 247 Query: 329 NDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC 388 D + +W S+ + +T +A P G D + ++ Sbjct: 248 EDGTLKIWNSST----YKVEKTLNVGLERSWCIATHPTGRKNYIASG--FDNGFTVLSLG 301 Query: 389 SGACLSAVDAHSQVCSILWSPHYK 412 + ++D V ++WS Sbjct: 302 NDEPTLSLD---PVGKLVWSGGKN 322 Score = 112 bits (281), Expect = 3e-25, Method: Composition-based stats. Identities = 38/241 (15%), Positives = 86/241 (35%), Gaps = 16/241 (6%) Query: 262 RNMTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP 319 + ++ S RV + ++ + + SG + + + V ++ V ++ Sbjct: 7 KTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYET-QVEVRSIQVTETPVRAGKFIA 65 Query: 320 DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSD 379 + G +D + V+ GE + F H ++++A P + VL+ G+ D Sbjct: 66 RKNWIIVGSDDFRIRVFNYNTGEK----VVDFEAHPDYIRSIAVHPTKPYVLS---GSDD 118 Query: 380 RHIRIWNVCSGACL-SAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVA 437 +++WN + L + H V + ++P G + +W Sbjct: 119 LTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPS-TFASGCLDRTVKVWSLGQSTPNF 177 Query: 438 ELK-GHTSRVLSLTM--SPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLI 494 L G V + PD + +A+ D T+++W E ++ + + Sbjct: 178 TLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFH 237 Query: 495 H 495 Sbjct: 238 P 238 Score = 64.0 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 27/177 (15%), Positives = 60/177 (33%), Gaps = 16/177 (9%) Query: 158 PGSSRKTCRYIP---SLPDRILDAPEIRNDYYLNLVDWSSG-NVLAVALDNSVYLWSASS 213 G +T + S P+ L + R Y++ ++ + D ++ +W + Sbjct: 158 SGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQT 217 Query: 214 GDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGS 273 + +E +S + + G+ +++W+ K + + R Sbjct: 218 KSCVA--TLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWC 275 Query: 274 LSWNS----YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLAS 326 ++ + ++SG +G V + TLS V L W+ AS Sbjct: 276 IATHPTGRKNYIASGFDNG----FTVLSLGNDEPTLS--LDPVGKLVWSGGKNAAAS 326 >6HHQ-h nrPDB Length = 319 Score = 200 bits (509), Expect = 9e-52, Method: Composition-based stats. Identities = 58/298 (19%), Positives = 115/298 (38%), Gaps = 31/298 (10%) Query: 195 GNVLAVALDNSVYLWSASSGDI---LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQ 251 +L+ + D ++ W + D + + + + +G Y + ++ Sbjct: 31 NLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLR 90 Query: 252 LWDVQQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHS 309 LWDV + + H + V S+ + + ++ SGSR I ++ +ATL GH+ Sbjct: 91 LWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKG--QCLATLLGHN 148 Query: 310 QEVCGLRWAPDGR------HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAW 363 V +R P+ + + S GND +V W + F H + + Sbjct: 149 DWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNL----NQFQIEADFIGHNSNINTLTA 204 Query: 364 CPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQN 423 P + + + G D I +WN+ + + + A +V S+ +SP+ L + Sbjct: 205 SPDGTLIASAG---KDGEIMLWNLAAKKAMYTLSAQDEVFSLAFSPNRYWLAAATATG-- 259 Query: 424 QLVIWKYPTMAKVAEL--------KGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 + ++ V +L K +SL S DG T+ + D +R+W+ Sbjct: 260 -IKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVM 316 Score = 161 bits (408), Expect = 5e-40, Method: Composition-based stats. Identities = 55/223 (24%), Positives = 87/223 (39%), Gaps = 20/223 (8%) Query: 263 NMTSHSARVGSLSWN---SYILSSGSRSGHIHHH----DVRVAEHHVATLSGHSQEVCGL 315 + H+ V SL+ + +L S SR + D + V + GHS V Sbjct: 12 TLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDC 71 Query: 316 RWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGG 375 DG + S D + +W A GE Q F H+ V +V S +++ Sbjct: 72 TLTADGAYALSASWDKTLRLWDVATGE----TYQRFVGHKSDVMSVDIDKKASMIIS--- 124 Query: 376 GTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPH----YKELISGHGFAQNQLVIWKY 430 G+ D+ I++W + G CL+ + H V + P+ + + W Sbjct: 125 GSRDKTIKVWTI-KGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNL 183 Query: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 A+ GH S + +LT SPDG +ASA D + LW Sbjct: 184 NQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLA 226 Score = 99.9 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 44/247 (17%), Positives = 98/247 (39%), Gaps = 22/247 (8%) Query: 158 PGSSRKTCRYIP-SLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDI 216 S KT R + + ++D +D + +++ + D ++ +W+ G Sbjct: 82 SASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIK-GQC 140 Query: 217 LQLLQMEQPGEYISSVAWIK------EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSAR 270 L + +++S V + + + + V+ W++ Q + + H++ Sbjct: 141 --LATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSN 198 Query: 271 VGSL--SWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGG 328 + +L S + +++S + G I ++ A+ + TLS EV L ++P+ LA+ Sbjct: 199 INTLTASPDGTLIASAGKDGEIMLWNL-AAKKAMYTLSA-QDEVFSLAFSPNRYWLAAAT 256 Query: 329 NDNLVNVWPSAPGEGGWVPLQTFTQHQGAVK----AVAWCPWQSNVLATGGGTSDRHIRI 384 + V+ P F + A + ++AW + A G +D IR+ Sbjct: 257 ATG-IKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFA---GYTDNVIRV 312 Query: 385 WNVCSGA 391 W V + Sbjct: 313 WQVMTAN 319 Score = 59.8 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 31/117 (26%), Positives = 46/117 (39%), Gaps = 13/117 (11%) Query: 395 AVDAHS-QVCSILWSPHYKELISGHGFAQNQLVIW-----KYPTMAKVAELKGHTSRVLS 448 ++ H+ V S+ S L+ L+ W V KGH+ V Sbjct: 12 TLEGHNGWVTSLATSAGQPNLLL-SASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQD 70 Query: 449 LTMSPDGATVASAAADETLRLWRCFELDPARRREREK------ASAAKSSLIHQGIR 499 T++ DGA SA+ D+TLRLW + +R K K+S+I G R Sbjct: 71 CTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSR 127 >3JAP-g nrPDB Length = 326 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 64/302 (21%), Positives = 111/302 (36%), Gaps = 33/302 (10%) Query: 195 GNVLAVALDNSVYLWSASSGDI---LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQ 251 +++ + D ++ W + + + + + + V +GNY + ++ Sbjct: 32 NLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVVVSADGNYAVSASWDKTLR 91 Query: 252 LWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHS 309 LW++ H+ V S++ NS + S SR I + +V L GH+ Sbjct: 92 LWNLATGNSEARFVGHTGDVLSVAIDANSSKIISASRDKTIRVWNTVGDCAYV--LLGHT 149 Query: 310 QEVCGLRWAP---------DGR-HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVK 359 V +R AP DGR S G D +V W E + F H + Sbjct: 150 DWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSL--NEDSYRIEADFIGHNNYIN 207 Query: 360 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHG 419 V P S D I +WN+ + DA +V ++ +SP L + Sbjct: 208 VVQPSPDGS---LAASAGKDGQIYVWNLKHKSAFMNFDAKDEVFALAFSPSRFWLTAATA 264 Query: 420 FAQNQLVIWKYPTMAKVAELK----GHTS----RVLSLTMSPDGATVASAAADETLRLWR 471 + I+ + ELK G+T +SL S DG T+ + D +R+W+ Sbjct: 265 SG---IKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQ 321 Query: 472 CF 473 Sbjct: 322 VM 323 Score = 144 bits (363), Expect = 9e-35, Method: Composition-based stats. Identities = 53/228 (23%), Positives = 86/228 (37%), Gaps = 26/228 (11%) Query: 263 NMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHH----VATLSGHSQEVCGL 315 + H+ V SLS + +L SGSR + + E V + GHS V + Sbjct: 13 TLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDV 72 Query: 316 RWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGG 375 + DG + S D + +W A G F H G V +VA S +++ Sbjct: 73 VVSADGNYAVSASWDKTLRLWNLATGNSE----ARFVGHTGDVLSVAIDANSSKIIS--- 125 Query: 376 GTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSP--------HYKELISGHGFAQNQLV 426 + D+ IR+WN G C + H+ V + +P + + Sbjct: 126 ASRDKTIRVWNTV-GDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVR 184 Query: 427 IWKYP--TMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 W + A+ GH + + + SPDG+ ASA D + +W Sbjct: 185 SWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNL 232 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 42/185 (22%), Positives = 73/185 (39%), Gaps = 19/185 (10%) Query: 303 ATLSGHSQEVCGLRWAPDG-RHLASGGNDNLVNVWPSAPGEGGW-VPLQTFTQHQGAVKA 360 TL GH+ V L + L SG D + W E + VP++++ H V+ Sbjct: 12 GTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQD 71 Query: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHG 419 V + ++ + D+ +R+WN+ +G + H+ V S+ + ++IS Sbjct: 72 VVVSADGNYAVS---ASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISAS- 127 Query: 420 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP---------DGAT-VASAAADETLRL 469 + +W L GHT V + ++P DG SA D+ +R Sbjct: 128 -RDKTIRVWNT-VGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRS 185 Query: 470 WRCFE 474 W E Sbjct: 186 WSLNE 190 Score = 85.6 bits (210), Expect = 5e-17, Method: Composition-based stats. Identities = 31/140 (22%), Positives = 56/140 (40%), Gaps = 10/140 (7%) Query: 338 SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGAC----- 392 + V T H G V +++ Q N+L G+ D+ + W + Sbjct: 1 MSSSNIMLVLRGTLEGHNGWVTSLSTSAAQPNLL--VSGSRDKTLISWRLTENEQQFGVP 58 Query: 393 LSAVDAHSQVC-SILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTM 451 + + HS + ++ S +S L +W T A GHT VLS+ + Sbjct: 59 VRSYKGHSHIVQDVVVSADGNYAVSAS--WDKTLRLWNLATGNSEARFVGHTGDVLSVAI 116 Query: 452 SPDGATVASAAADETLRLWR 471 + + + SA+ D+T+R+W Sbjct: 117 DANSSKIISASRDKTIRVWN 136 Score = 58.6 bits (140), Expect = 6e-09, Method: Composition-based stats. Identities = 25/98 (25%), Positives = 38/98 (38%), Gaps = 7/98 (7%) Query: 395 AVDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKY-----PTMAKVAELKGHTSRVLS 448 ++ H+ V S+ S L+ G L+ W+ V KGH+ V Sbjct: 13 TLEGHNGWVTSLSTSAAQPNLLV-SGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQD 71 Query: 449 LTMSPDGATVASAAADETLRLWRCFELDPARRREREKA 486 + +S DG SA+ D+TLRLW + R Sbjct: 72 VVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTG 109 Score = 31.3 bits (69), Expect = 0.98, Method: Composition-based stats. Identities = 11/68 (16%), Positives = 27/68 (39%), Gaps = 6/68 (8%) Query: 198 LAVALDNSVYLWSASSGDILQLLQ------MEQPGEYISSVAWIKEGNYLAVGTSSAEVQ 251 L A + + ++ + ++ L+ + + S+AW +G L G + ++ Sbjct: 259 LTAATASGIKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIR 318 Query: 252 LWDVQQQK 259 +W V Sbjct: 319 VWQVMTAN 326 >5WLC-LO nrPDB Length = 923 Score = 198 bits (502), Expect = 7e-51, Method: Composition-based stats. Identities = 63/323 (19%), Positives = 121/323 (37%), Gaps = 40/323 (12%) Query: 182 RNDYYLNLV-DWSSGNVLAVALDNSVYLW-------------------------SASSGD 215 DY + + V+ D +V++W S S Sbjct: 190 HRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWR 249 Query: 216 ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS 275 I + + V + LAVG +S E +L+D+ ++ ++ V ++S Sbjct: 250 ITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVS 309 Query: 276 WN--SYILSSGSRS-GHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNL 332 N L+ GS G + ++ + ++ GH L ++PDG + + D Sbjct: 310 VNQTGEWLAFGSSKLGQLLVYEWQSES-YILKQQGHFDSTNSLAYSPDGSRVVTASEDGK 368 Query: 333 VNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGAC 392 + VW G L TF +H +V AV + + ++ + D +R W++ Sbjct: 369 IKVWDITSG----FCLATFEEHTSSVTAVQFAKRGQVMFSS---SLDGTVRAWDLIRYRN 421 Query: 393 LSAVDAHSQV--CSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLT 450 ++ + P + + +G + +W T + L GH V L+ Sbjct: 422 FRTFTGTERIQFNCLAVDPSGEVVCAGS-LDNFDIHVWSVQTGQLLDALSGHEGPVSCLS 480 Query: 451 MSPDGATVASAAADETLRLWRCF 473 S + + +ASA+ D+T+R+W F Sbjct: 481 FSQENSVLASASWDKTIRIWSIF 503 Score = 148 bits (372), Expect = 7e-36, Method: Composition-based stats. Identities = 62/355 (17%), Positives = 129/355 (36%), Gaps = 45/355 (12%) Query: 180 EIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGN 239 E R + ++ ++++ D L + + ++L + E S+V + +G Sbjct: 53 EHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFK---EKCSAVKFSPDGR 109 Query: 240 YLAVGTSSAEVQLWDVQQQKRLRNMT---------SHSARVGSLSW--NSYILSSGSRSG 288 A+ + +Q+W + R H + SL+W +S + + S+ Sbjct: 110 LFALAS-GRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDL 168 Query: 289 HIHHHDVRVAEHHVA--TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW---------- 336 V E ++A T +GH V G ++ D + + D V VW Sbjct: 169 SAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDD 228 Query: 337 -------------PSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIR 383 + F +Q VK V + P +LA G + R Sbjct: 229 DNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATR-LLAVGFTS--GEFR 285 Query: 384 IWNVCSGACLSAVD-AHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGH 442 ++++ + + + V ++ + + L G QL+++++ + + + + +GH Sbjct: 286 LYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSS-KLGQLLVYEWQSESYILKQQGH 344 Query: 443 TSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 SL SPDG+ V +A+ D +++W E +S +G Sbjct: 345 FDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRG 399 Score = 138 bits (347), Expect = 6e-33, Method: Composition-based stats. Identities = 47/268 (17%), Positives = 95/268 (35%), Gaps = 35/268 (13%) Query: 196 NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV 255 V+ + D + +W +SG L + +++V + K G + + V+ WD+ Sbjct: 359 RVVTASEDGKIKVWDITSGFCLATFEEHTSS--VTAVQFAKRGQVMFSSSLDGTVRAWDL 416 Query: 256 QQQKRLRNMTSHSARV--GSLSWNSY--ILSSGSRSGH-IHHHDVRVAEHHVATLSGHSQ 310 + + R T + R+ L+ + ++ +GS IH V+ + A LSGH Sbjct: 417 IRYRNFRTFTG-TERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDA-LSGHEG 474 Query: 311 EVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370 V L ++ + LAS D + +W P++ + V A++ P V Sbjct: 475 PVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVY----SDVLALSMRPDGKEV 530 Query: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHY------------------- 411 + T I I+N+ + +D + S ++ Sbjct: 531 AVS---TLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSF 587 Query: 412 KELISGHGFAQNQLVIWKYPTMAKVAEL 439 + G N + ++ P + Sbjct: 588 DGMAIVAGGNNNSICLYDVPNEVLLKRF 615 >4A11-B nrPDB Length = 408 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 74/344 (21%), Positives = 143/344 (41%), Gaps = 40/344 (11%) Query: 110 KEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIP 169 + + ++ G I + G+ + G + + VLY + + S TC+ + Sbjct: 33 NKDRDVERIHGGGI--NTLDIEPVEGRYMLS--GGSDGVIVLYDLENSSRQSYYTCKAVC 88 Query: 170 SLPDRILDAPEIRNDYYLNLVDW---SSGNVLAVALDNSVYLWSASSGDILQLLQMEQP- 225 S+ D P++ Y + V W +G + + D ++ +W ++ + E+ Sbjct: 89 SIGR---DHPDVHR-YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETV 144 Query: 226 -GEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS---YIL 281 ++S V + +AVGT +VQL D++ + H + ++SW+ YIL Sbjct: 145 YSHHMSPV--STKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYIL 202 Query: 282 SSGSRSGHIHHHDVRVAEHHVATL---------------SGHSQEVCGLRWAPDGRHLAS 326 ++ S + DVR A + TL + H+ +V GL + DG HL + Sbjct: 203 ATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLT 262 Query: 327 GGNDNLVNVWPSAPGEGGWVPL-QTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW 385 G DN + +W S+ GE V + + +K C S + G+ I ++ Sbjct: 263 VGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGS---TIAVY 319 Query: 386 NVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIW 428 V SG ++ + H + V ++ +++EL SG ++ W Sbjct: 320 TVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGS--RDCNILAW 361 Score = 121 bits (303), Expect = 7e-28, Method: Composition-based stats. Identities = 50/310 (16%), Positives = 110/310 (35%), Gaps = 43/310 (13%) Query: 197 VLAVALDNSVYLWSA--------SSGDILQLLQMEQPGEY---ISSVAWIK-EGNYLAVG 244 +L+ D + L+ + + + + P + + +V W + Sbjct: 59 MLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSS 118 Query: 245 TSSAEVQLWDVQQQKRLRNM----TSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH 300 + +++WD + T +S + +S +++ G+R + D++ Sbjct: 119 SFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGS- 177 Query: 301 HVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ------ 353 L GH QE+ + W+P LA+ D+ V +W G + L Sbjct: 178 CSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAV 237 Query: 354 ------HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILW 407 H G V + + ++L G D +R+WN +G + + + +VC+ Sbjct: 238 ESANTAHNGKVNGLCFTSDGLHLLTVGT---DNRMRLWNSSNGE--NTLVNYGKVCN-NS 291 Query: 408 SPHYKELISGHGFAQ-------NQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVAS 460 K +S ++ + + ++ + ++ LKGH V + + S Sbjct: 292 KKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYS 351 Query: 461 AAADETLRLW 470 + D + W Sbjct: 352 GSRDCNILAW 361 Score = 104 bits (260), Expect = 8e-23, Method: Composition-based stats. Identities = 42/244 (17%), Positives = 80/244 (32%), Gaps = 39/244 (15%) Query: 267 HSARVGSLSWNS---YILSSGSRSGHIHHHDVRVAEHHVA-TLSG-----------HSQE 311 H + +L + SG G I +D+ + T H Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 312 VCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370 V ++W P D S D + VW + F + V + P + Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWD--TNTLQTADVFNFEE---TVYSHHMSPVSTKH 156 Query: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWK 429 GT +++ ++ SG+C + H ++ ++ WSP Y ++ A +++ +W Sbjct: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYIL-ATASADSRVKLWD 215 Query: 430 YPTMA-KVAELK---------------GHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 + + L H +V L + DG + + D +RLW Sbjct: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 Query: 474 ELDP 477 + Sbjct: 276 NGEN 279 >5I2T-A nrPDB Length = 742 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 63/323 (19%), Positives = 121/323 (37%), Gaps = 40/323 (12%) Query: 182 RNDYYLNLV-DWSSGNVLAVALDNSVYLW-------------------------SASSGD 215 DY + + V+ D +V++W S S Sbjct: 215 HRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWR 274 Query: 216 ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS 275 I + + V + LAVG +S E +L+D+ ++ ++ V ++S Sbjct: 275 ITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVS 334 Query: 276 WN--SYILSSGSRS-GHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNL 332 N L+ GS G + ++ + ++ GH L ++PDG + + D Sbjct: 335 VNQTGEWLAFGSSKLGQLLVYEWQSES-YILKQQGHFDSTNSLAYSPDGSRVVTASEDGK 393 Query: 333 VNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGAC 392 + VW G L TF +H +V AV + + ++ + D +R W++ Sbjct: 394 IKVWDITSG----FCLATFEEHTSSVTAVQFAKRGQVMFSS---SLDGTVRAWDLIRYRN 446 Query: 393 LSAVDAHSQV--CSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLT 450 ++ + P + + +G + +W T + L GH V L+ Sbjct: 447 FRTFTGTERIQFNCLAVDPSGEVVCAGS-LDNFDIHVWSVQTGQLLDALSGHEGPVSCLS 505 Query: 451 MSPDGATVASAAADETLRLWRCF 473 S + + +ASA+ D+T+R+W F Sbjct: 506 FSQENSVLASASWDKTIRIWSIF 528 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 62/355 (17%), Positives = 129/355 (36%), Gaps = 45/355 (12%) Query: 180 EIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGN 239 E R + ++ ++++ D L + + ++L + E S+V + +G Sbjct: 78 EHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFK---EKCSAVKFSPDGR 134 Query: 240 YLAVGTSSAEVQLWDVQQQKRLRNMT---------SHSARVGSLSW--NSYILSSGSRSG 288 A+ + +Q+W + R H + SL+W +S + + S+ Sbjct: 135 LFALAS-GRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDL 193 Query: 289 HIHHHDVRVAEHHVA--TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW---------- 336 V E ++A T +GH V G ++ D + + D V VW Sbjct: 194 SAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDD 253 Query: 337 -------------PSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIR 383 + F +Q VK V + P +LA G + R Sbjct: 254 DNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATR-LLAVGFTS--GEFR 310 Query: 384 IWNVCSGACLSAVD-AHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGH 442 ++++ + + + V ++ + + L G QL+++++ + + + + +GH Sbjct: 311 LYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSS-KLGQLLVYEWQSESYILKQQGH 369 Query: 443 TSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 SL SPDG+ V +A+ D +++W E +S +G Sbjct: 370 FDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRG 424 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 47/268 (17%), Positives = 95/268 (35%), Gaps = 35/268 (13%) Query: 196 NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV 255 V+ + D + +W +SG L + +++V + K G + + V+ WD+ Sbjct: 384 RVVTASEDGKIKVWDITSGFCLATFEEHTSS--VTAVQFAKRGQVMFSSSLDGTVRAWDL 441 Query: 256 QQQKRLRNMTSHSARV--GSLSWNSY--ILSSGSRSGH-IHHHDVRVAEHHVATLSGHSQ 310 + + R T + R+ L+ + ++ +GS IH V+ + A LSGH Sbjct: 442 IRYRNFRTFTG-TERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDA-LSGHEG 499 Query: 311 EVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370 V L ++ + LAS D + +W P++ + V A++ P V Sbjct: 500 PVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVY----SDVLALSMRPDGKEV 555 Query: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHY------------------- 411 + T I I+N+ + +D + S ++ Sbjct: 556 AVS---TLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSF 612 Query: 412 KELISGHGFAQNQLVIWKYPTMAKVAEL 439 + G N + ++ P + Sbjct: 613 DGMAIVAGGNNNSICLYDVPNEVLLKRF 640 >4V7E-Bg nrPDB Length = 380 Score = 194 bits (494), Expect = 6e-50, Method: Composition-based stats. Identities = 58/311 (18%), Positives = 120/311 (38%), Gaps = 41/311 (13%) Query: 190 VDWSSGN--VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247 +DW+ +++ + D + +W+A + +++ P ++ A+ G +A G Sbjct: 72 LDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCP--WVMECAFAPNGQSVACGGLD 129 Query: 248 AEVQLWDVQQQKR-------LRNMTSHSARVGSLSWNSYI---LSSGSRSGHIHHHDVRV 297 + ++++ Q R +T H S + L +GS DV Sbjct: 130 SACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTT 189 Query: 298 AEHHVATL-----SGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTF 351 + ++ SGH+ +V L + SG D V +W ++T+ Sbjct: 190 GQR-ISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLR---ITSRAVRTY 245 Query: 352 TQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ--------VC 403 H+G + +V + P G G+ D R++++ +G L + V Sbjct: 246 HGHEGDINSVKFFPDGQRF---GTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVT 302 Query: 404 SILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL----KGHTSRVLSLTMSPDGATVA 459 S+ +S + L + G++ +W V L H R+ L +S DG+ + Sbjct: 303 SVAFSISGRLLFA--GYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSALC 360 Query: 460 SAAADETLRLW 470 + + D+ L++W Sbjct: 361 TGSWDKNLKIW 371 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 60/314 (19%), Positives = 113/314 (35%), Gaps = 37/314 (11%) Query: 156 ATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVA-LDNSVYLWSASS- 213 S +L + A ++ + + +G +A LD++ +++ SS Sbjct: 81 IVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPNGQSVACGGLDSACSIFNLSSQ 140 Query: 214 ----GDILQLLQMEQPGEYISSVAWIKEG-NYLAVGTSSAEVQLWDVQQQKRLRNM---- 264 G++ + Y SS ++ + L G+ LWDV +R+ Sbjct: 141 ADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEF 200 Query: 265 -TSHSARVGSLSWNS---YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD 320 + H+A V SLS NS + SGS + D+R+ V T GH ++ +++ PD Sbjct: 201 PSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFPD 260 Query: 321 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGA---VKAVAWCPWQSNVLATGGGT 377 G+ +G +D ++ G V + ++ V +VA+ + A G Sbjct: 261 GQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFA---GY 317 Query: 378 SDRHIRIWNVCSGACLSAV-----DAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPT 432 S+ +W+ + + ++ + S L +G L IW Sbjct: 318 SNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSALCTGS--WDKNLKIW---- 371 Query: 433 MAKVAELKGHTSRV 446 GH V Sbjct: 372 -----AFSGHRKIV 380 Score = 151 bits (381), Expect = 7e-37, Method: Composition-based stats. Identities = 43/281 (15%), Positives = 100/281 (35%), Gaps = 23/281 (8%) Query: 210 SASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSA 269 S + D++ ++ + S+ W E N++ + + +W+ ++ + H Sbjct: 50 SFNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCP 109 Query: 270 RVGSLSW--NSYILSSGSRSGHIHHHDV-----RVAEHHV-ATLSGHSQEVCGLRWAPD- 320 V ++ N ++ G ++ R V L+GH ++ PD Sbjct: 110 WVMECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQ 169 Query: 321 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTF-TQHQGAVKAVAWCPWQSNVLATGGGTSD 379 L +G D +W G+ + F + H V +++ +N+ + G+ D Sbjct: 170 ETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFIS--GSCD 227 Query: 380 RHIRIWNVC-SGACLSAVDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVA 437 +R+W++ + + H + S+ + P + G G ++ T ++ Sbjct: 228 TTVRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRF--GTGSDDGTCRLFDMRTGHQLQ 285 Query: 438 ELKGHTSR-------VLSLTMSPDGATVASAAADETLRLWR 471 R V S+ S G + + ++ +W Sbjct: 286 VYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWD 326 Score = 141 bits (356), Expect = 6e-34, Method: Composition-based stats. Identities = 52/238 (21%), Positives = 88/238 (36%), Gaps = 14/238 (5%) Query: 260 RLRNMTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRW 317 R + HS +V SL W + S S+ G + + + H V + Sbjct: 58 CCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALT-SQKTHAIKLHCPWVMECAF 116 Query: 318 APDGRHLASGGNDNLVNVWPSAP---GEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATG 374 AP+G+ +A GG D+ +++ + +G + T H+G + + P Q L TG Sbjct: 117 APNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITG 176 Query: 375 GGTSDRHIRIWNVCSGACLSAV-----DAHSQVCSILWSPHYKELISGHGFAQNQLVIWK 429 G D+ +W+V +G +S H+ L + G + +W Sbjct: 177 SG--DQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWD 234 Query: 430 YP-TMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKA 486 T V GH + S+ PDG + + D T RL+ + RE Sbjct: 235 LRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPD 292 >6ID0-T nrPDB Length = 514 Score = 194 bits (493), Expect = 7e-50, Method: Composition-based stats. Identities = 54/260 (20%), Positives = 104/260 (40%), Gaps = 15/260 (5%) Query: 224 QPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGS--LSWNSYIL 281 ++ +A + G++ +++WD+ K ++T H + V +S S L Sbjct: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYL 261 Query: 282 SSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPG 341 S + D+ + GH V GL P L + D+ +W Sbjct: 262 FSCGEDKQVKCWDLEY-NKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTK 320 Query: 342 EGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ 401 + T + H AV V + ++ G+ D IR+W++ +G + H + Sbjct: 321 AS----VHTLSGHTNAVATVRCQAAEPQII---TGSHDTTIRLWDLVAGKTRVTLTNHKK 373 Query: 402 -VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVAS 460 V +++ P + SG + + WK+P + + L GH + + +LT++ DG + S Sbjct: 374 SVRAVVLHPRHYTFASGSP---DNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVS 429 Query: 461 AAADETLRLWRCFELDPARR 480 A + T+ LW +R Sbjct: 430 GADNGTMHLWDWRTGYNFQR 449 Score = 174 bits (442), Expect = 6e-44, Method: Composition-based stats. Identities = 62/307 (20%), Positives = 119/307 (38%), Gaps = 25/307 (8%) Query: 186 YLNLVDWSSGN--VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAV 243 ++ + GN + + D ++ +W +SG + L + + V YL Sbjct: 206 WVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLK--LSLTGHISTVRGVIVSTRSPYLFS 263 Query: 244 GTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYI--LSSGSRSGHIHHHDVRVAEHH 301 +V+ WD++ K +R+ H + V L + I L + SR DVR + Sbjct: 264 CGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRT-KAS 322 Query: 302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 361 V TLSGH+ V +R + +G +D + +W G+ T T H+ +V+AV Sbjct: 323 VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRV----TLTNHKKSVRAV 378 Query: 362 AWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFA 421 P G+ D I+ W G+ + + H+ + + L L+SG Sbjct: 379 VLHPRH---YTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGAD-- 432 Query: 422 QNQLVIWKYPTMAKVAELKGH--------TSRVLSLTMSPDGATVASAAADETLRLWRCF 473 + +W + T + S + + + + +A AD+T++++R Sbjct: 433 NGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYRED 492 Query: 474 ELDPARR 480 + Sbjct: 493 DTATEET 499 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 41/284 (14%), Positives = 96/284 (33%), Gaps = 26/284 (9%) Query: 157 TPGSSRKTCRYIPSLPDRI-LDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGD 215 GS+ +T + ++ L + +V S + + D V W Sbjct: 220 VTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNK 279 Query: 216 ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS 275 +++ + + + L + + ++WDV+ + + ++ H+ V ++ Sbjct: 280 VIR--HYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVR 337 Query: 276 --WNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLV 333 + +GS I D+ + V TL+ H + V + P ASG DN + Sbjct: 338 CQAAEPQIITGSHDTTIRLWDLVAGKTRV-TLTNHKKSVRAVVLHPRHYTFASGSPDN-I 395 Query: 334 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACL 393 W G +Q + H + + G + + +W+ +G Sbjct: 396 KQWKFPDG----SFIQNLSGHNAIINTLTVNSDG----VLVSGADNGTMHLWDWRTGYNF 447 Query: 394 S---------AVDAHSQVCSILWSPHYKELISGHGFAQNQLVIW 428 ++D+ S + + + L++ A + ++ Sbjct: 448 QRVHAAVQPGSLDSESGIFACAFDQSESRLLTA--EADKTIKVY 489 Score = 128 bits (321), Expect = 6e-30, Method: Composition-based stats. Identities = 37/171 (21%), Positives = 65/171 (38%), Gaps = 10/171 (5%) Query: 303 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 +SGH V + P + +G D + +W A G+ + T H V+ V Sbjct: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL----SLTGHISTVRGVI 253 Query: 363 WCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFA 421 + + G D+ ++ W++ + H S V + P L++ Sbjct: 254 VSTRSPYLFSCG---EDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCS--R 308 Query: 422 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 + IW T A V L GHT+ V ++ + + + D T+RLW Sbjct: 309 DSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDL 359 Score = 107 bits (267), Expect = 1e-23, Method: Composition-based stats. Identities = 33/150 (22%), Positives = 55/150 (36%), Gaps = 6/150 (4%) Query: 341 GEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH- 399 W + + H G V+ +A P + G++DR I+IW++ SG ++ H Sbjct: 190 WHPPWKLYRVISGHLGWVRCIAVEPGNQWFV---TGSADRTIKIWDLASGKLKLSLTGHI 246 Query: 400 SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVA 459 S V ++ S L S Q+ W + GH S V L + P + Sbjct: 247 STVRGVIVSTRSPYLFSCG--EDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLV 304 Query: 460 SAAADETLRLWRCFELDPARRREREKASAA 489 + + D T R+W + A Sbjct: 305 TCSRDSTARIWDVRTKASVHTLSGHTNAVA 334 Score = 90.2 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 36/227 (15%), Positives = 75/227 (33%), Gaps = 19/227 (8%) Query: 126 EEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPG-------SSRKTCRYIP-SLPDRILD 177 E+ ++ + Y L +Y P S T R + Sbjct: 266 EDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHT 325 Query: 178 APEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKE 237 N + ++ + D ++ LW +G + + + + +V Sbjct: 326 LSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTR--VTLTNHKKSVRAVVLHPR 383 Query: 238 GNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY-ILSSGSRSGHIHHHDVR 296 A G+ ++ W ++N++ H+A + +L+ NS +L SG+ +G +H D R Sbjct: 384 HYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWR 442 Query: 297 VAEH----HVATLSGHSQ---EVCGLRWAPDGRHLASGGNDNLVNVW 336 + H A G + + L + D + V+ Sbjct: 443 TGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489 >5WYJ-BC nrPDB Length = 817 Score = 193 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 55/270 (20%), Positives = 110/270 (40%), Gaps = 30/270 (11%) Query: 223 EQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMT----SHSARVGSLSWN- 277 E + ++S+ ++G ++A + +W + ++ HSA V ++ Sbjct: 385 EGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPN 444 Query: 278 ------SYILSSGSRSGHIHHH---------DVRVAEHHVATLSGHSQEVCGLRWAPDGR 322 L + S I DV++ + T H +++ L +P+ Sbjct: 445 IVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDS 504 Query: 323 HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHI 382 A+ D +W GE T H+ + V++C + +LAT G D+ + Sbjct: 505 IFATASYDKTCKIWNLENGE----LEATLANHKRGLWDVSFCQYD-KLLATSSG--DKTV 557 Query: 383 RIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKG 441 +IW++ + + + ++ H+ V + K+LIS A + IW + + L G Sbjct: 558 KIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCG--ADGLIKIWDCSSGECLKTLDG 615 Query: 442 HTSRVLSLTMSPDGATVASAAADETLRLWR 471 H +R+ +L+ DG + SA AD + W+ Sbjct: 616 HNNRLWALSTMNDGDMIVSADADGVFQFWK 645 Score = 145 bits (366), Expect = 4e-35, Method: Composition-based stats. Identities = 58/338 (17%), Positives = 124/338 (36%), Gaps = 39/338 (11%) Query: 193 SSGNVLAVALDNSVYLWSASSG-----DILQLLQMEQPGEYIS-SVAWI-KEGNYLAVGT 245 S+ + V D ++ L + D +Q+ I + ++ E N LA+ T Sbjct: 298 SNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALAT 357 Query: 246 SSAEVQLW---DVQQQKR-----LRNMTSHSARVGSL--SWNSYILSSGSRSGHIHHHDV 295 +S +++ D+ + + H + SL + + +++ S+ Sbjct: 358 NSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRY 417 Query: 296 RVAEHHVATLS---GHSQEVCGLRWAPDG------RHLASGGNDNLVNVW----PSAPGE 342 + GHS V + P+ L + ND + W P+A + Sbjct: 418 NENSCKFDIYAKYIGHSAAVTAVGL-PNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMD 476 Query: 343 GGWVPLQTFT--QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS 400 + + +T H+ + A++ P S + D+ +IWN+ +G + + H Sbjct: 477 VQIIKVSEYTRHAHEKDINALSVSPNDSIF---ATASYDKTCKIWNLENGELEATLANHK 533 Query: 401 -QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVA 459 + + + + K L + G + IW T + + L+GHT+ V + + Sbjct: 534 RGLWDVSFCQYDKLLATSSG--DKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLI 591 Query: 460 SAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 S AD +++W C + + + S ++ G Sbjct: 592 SCGADGLIKIWDCSSGECLKTLDGHNNRLWALSTMNDG 629 Score = 112 bits (279), Expect = 5e-25, Method: Composition-based stats. Identities = 75/405 (18%), Positives = 146/405 (36%), Gaps = 43/405 (10%) Query: 103 NSQTPTKKEHQKAWA---LNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPG 159 +S T E+ K A L+ ++ K N E LK+ + Sbjct: 19 SSAVATVSENGKILATPVLDEINIIDLTPGSRKILHKISNEDEQEITALKLTPDGQYLTY 78 Query: 160 SSRKTCRYIPSL-PDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQ 218 S+ I L +++ + +I + Y+ D +S + D S+ + +G I Sbjct: 79 VSQAQLLKIFHLKTGKVVRSMKISSPSYILDADSTSTLLAVGGTDGSIIVVDIENGYITH 138 Query: 219 LLQMEQPGEYISSVAWIKEGN----YLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSL 274 + G ISS+ + + N LA G ++ V++WD+ ++K L + H++ V L Sbjct: 139 --SFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGL 196 Query: 275 SW--------NSYILSSGSRSGHIHHHDVRVAEHHVATLSGH-SQEVCGLRWAPDG---R 322 S L SG R I+ D + + + +Q+V + DG R Sbjct: 197 DIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKR 256 Query: 323 HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHI 382 + + G D + + S G + + + V S + D+ + Sbjct: 257 IIYTAGGDAIFQLIDSESGSVLKRTNKPIE--ELFIIGVLPILSNSQMFLVLS---DQTL 311 Query: 383 RIWNVCSG--------ACLSAVDAHSQVCSIL--WSPHYKELISGHGFAQNQLV-IWKYP 431 ++ NV S++ + + + + P +L +++ + Sbjct: 312 QLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLS 371 Query: 432 TMAK-----VAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 V +GH + SL + DG +A+A+ D T +WR Sbjct: 372 GPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWR 416 Score = 68.3 bits (165), Expect = 7e-12, Method: Composition-based stats. Identities = 23/182 (12%), Positives = 63/182 (34%), Gaps = 11/182 (6%) Query: 317 WAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGG 376 + +G+ LA+ D +N+ PG + + + + + A+ P + Sbjct: 25 VSENGKILATPVLDE-INIIDLTPG-SRKILHKISNEDEQEITALKLTPDGQYLTYVSQA 82 Query: 377 TSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKV 436 + ++I+++ +G + ++ S S + + G +++ Sbjct: 83 ---QLLKIFHLKTGKVVRSMKISSP--SYILDADSTSTLLAVGGTDGSIIVVDIENGYIT 137 Query: 437 AELKGHTSRVLSLTM----SPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSS 492 KGH + SL + +AS + +++W + + ++ Sbjct: 138 HSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLD 197 Query: 493 LI 494 +I Sbjct: 198 II 199 Score = 53.2 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 18/123 (14%), Positives = 40/123 (32%), Gaps = 3/123 (2%) Query: 132 RLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNL-V 190 L N G + Y + S KT + ++ E + Sbjct: 524 ELEATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSF 583 Query: 191 DWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEV 250 +++ D + +W SSG+ L+ L + +++ + +G+ + + Sbjct: 584 INKQKQLISCGADGLIKIWDCSSGECLKTLD--GHNNRLWALSTMNDGDMIVSADADGVF 641 Query: 251 QLW 253 Q W Sbjct: 642 QFW 644 >5Y88-O nrPDB Length = 451 Score = 191 bits (484), Expect = 7e-49, Method: Composition-based stats. Identities = 75/377 (19%), Positives = 147/377 (38%), Gaps = 33/377 (8%) Query: 106 TPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTC 165 PT ++ D + + +P+ A E NR + L SQ+ + K Sbjct: 73 VPTDFSEASQAVISKKDHDTHASAFVNKIFQPEVAEELIVNRYEKLLSQRPEWHAPWKLS 132 Query: 166 RYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQP 225 R I ++ VD + + + D ++ +W ++G + L Sbjct: 133 RVING-------HLGWVRCVAIDPVD--NEWFITGSNDTTMKVWDLATGKLKTTLA--GH 181 Query: 226 GEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY--ILSS 283 + VA YL + V+ WD+++ + +R+ H + V ++S + ++++ Sbjct: 182 VMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIAT 241 Query: 284 GSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEG 343 R I D+R V TL GH + ++ P + S D V +W G+ Sbjct: 242 AGRDSVIKLWDMRT-RIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGK- 299 Query: 344 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVC 403 ++ T H+ +V+A A P + +V + T D IR W + G+ L+ ++ Sbjct: 300 ---TMKVLTHHKRSVRATALHPKEFSVAS--ACTDD--IRSWGLAEGSLLTNFESEKTGI 352 Query: 404 SILWSPHYKELISGHGFAQNQLVIWKYPTM---------AKVAELKGHTSRVLSLTMSPD 454 S + +++ G L + Y + V L+G S VL T Sbjct: 353 INTLSINQDDVLFAGG-DNGVLSFYDYKSGHKYQSLATREMVGSLEGERS-VLCSTFDKT 410 Query: 455 GATVASAAADETLRLWR 471 G + + AD+++++W+ Sbjct: 411 GLRLITGEADKSIKIWK 427 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 42/197 (21%), Positives = 71/197 (36%), Gaps = 17/197 (8%) Query: 303 ATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 361 ++GH V + P D +G ND + VW A G+ T H V+ V Sbjct: 133 RVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKT----TLAGHVMTVRDV 188 Query: 362 AWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGF 420 A + + + D+ ++ W++ + H S V ++ P + Sbjct: 189 AVSDRHPYLFSV---SEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLD--LIATAG 243 Query: 421 AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE------ 474 + + +W T V L GH + + +P V S++ D T+RLW Sbjct: 244 RDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKV 303 Query: 475 LDPARRREREKASAAKS 491 L +R R A K Sbjct: 304 LTHHKRSVRATALHPKE 320 Score = 59.0 bits (141), Expect = 5e-09, Method: Composition-based stats. Identities = 16/87 (18%), Positives = 31/87 (35%), Gaps = 4/87 (4%) Query: 390 GACLSAVDAH-SQVCSILWSP-HYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVL 447 ++ H V + P + I+G + +W T L GH V Sbjct: 129 WKLSRVINGHLGWVRCVAIDPVDNEWFITGSN--DTTMKVWDLATGKLKTTLAGHVMTVR 186 Query: 448 SLTMSPDGATVASAAADETLRLWRCFE 474 + +S + S + D+T++ W + Sbjct: 187 DVAVSDRHPYLFSVSEDKTVKCWDLEK 213 >6QDV-o nrPDB Length = 513 Score = 181 bits (460), Expect = 5e-46, Method: Composition-based stats. Identities = 67/392 (17%), Positives = 119/392 (30%), Gaps = 28/392 (7%) Query: 96 SKENQPENSQTPTKKEHQKAWALNLN-GFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQ 154 E +KE + A G EE + YQ R + Q Sbjct: 134 VDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQ 193 Query: 155 KATPGSSRKTCRYIPSLPDRILDAPEIRND--YYLNLVDWSSGNVLAVALDNSVYLWSAS 212 LP + + + L S +L+ ++D + LW Sbjct: 194 DVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVY 253 Query: 213 SGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVG 272 G+ L + + + + G ++LWD + + + T+ Sbjct: 254 -GERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVP-Y 311 Query: 273 SLSWNS-----YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASG 327 + +N + +G I D+R E V H V + + + R S Sbjct: 312 CVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEI-VQEYDRHLGAVNTIVFVDENRRFVST 370 Query: 328 GNDNLVNVWP-SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWN 386 +D + VW P + ++ + H AV P + + D I I+ Sbjct: 371 SDDKSLRVWEWDIPVDFKYIAEPSM--HSMP--AVTLSPNGKWL---ACQSMDNQILIFG 423 Query: 387 VCSG---ACLSAVDAH---SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK 440 + H C + +SP +ISG G +L IW + T + K Sbjct: 424 AQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDG--NGKLNIWDWKTTKLYSRFK 481 Query: 441 GHTSRVLSLTMSPDG-ATVASAAADETLRLWR 471 H + P + V + D ++LW Sbjct: 482 AHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 513 Score = 85.2 bits (209), Expect = 6e-17, Method: Composition-based stats. Identities = 26/157 (16%), Positives = 55/157 (35%), Gaps = 10/157 (6%) Query: 348 LQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC-SGACLSAVDAHSQ-VCSI 405 + ++ H V AV P ++L + + D I++W V CL HS+ V I Sbjct: 215 IHVWSGHTKGVSAVRLFPLSGHLLLSC--SMDCKIKLWEVYGERRCLRTFIGHSKAVRDI 272 Query: 406 LWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDG---ATVASAA 462 ++ + +S L +W T ++ + +PD + Sbjct: 273 CFNTAGTQFLSAA--YDRYLKLWDTETGQCISRFTNRKVP-YCVKFNPDEDKQNLFVAGM 329 Query: 463 ADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR 499 +D+ + W + + +R + + + R Sbjct: 330 SDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRR 366 Score = 55.6 bits (132), Expect = 5e-08, Method: Composition-based stats. Identities = 20/103 (19%), Positives = 37/103 (35%), Gaps = 14/103 (13%) Query: 380 RHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWK-YPTMAKVA 437 + I +W+ H++ V ++ P L+ ++ +W+ Y + Sbjct: 213 KQIHVWS-----------GHTKGVSAVRLFPLSGHLLL-SCSMDCKIKLWEVYGERRCLR 260 Query: 438 ELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 GH+ V + + G SAA D L+LW R Sbjct: 261 TFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISR 303 >3FM0-A nrPDB Length = 345 Score = 180 bits (457), Expect = 9e-46, Method: Composition-based stats. Identities = 63/324 (19%), Positives = 120/324 (37%), Gaps = 39/324 (12%) Query: 182 RNDYYLNLVDWSS--GNVLAVALDNSVYLWSASSGDILQLLQM-EQPGEYISSVAWIKEG 238 D + W+ + + D + +W + + E + VAW G Sbjct: 14 HPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCG 73 Query: 239 NYLAVGTSSAEVQLW--DVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHD 294 NYLA + A +W + + + + H V S++W + +L++ SR + + Sbjct: 74 NYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133 Query: 295 V--RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFT 352 V V+ L+ H+Q+V + W P LAS D+ V ++ E WV T Sbjct: 134 VDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY--REEEDDWVCCATLE 191 Query: 353 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW---------------NVCSGACLSAVD 397 H+ V ++A+ P + + + DR +RIW + S C+ + Sbjct: 192 GHESTVWSLAFDPSGQRLASC---SDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLS 248 Query: 398 A-HSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL-------KGHTSRVLS 448 HS+ + I W L + G ++ + + + H+ V Sbjct: 249 GFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNC 308 Query: 449 LTMSPDGA-TVASAAADETLRLWR 471 + +P +AS + D + W+ Sbjct: 309 VAWNPKEPGLLASCSDDGEVAFWK 332 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 60/221 (27%), Positives = 98/221 (44%), Gaps = 13/221 (5%) Query: 268 SARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATL--SGHSQEVCGLRWAPDGRH 323 +R L+WN +L+S I ++ GH + V + W+P G + Sbjct: 16 DSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNY 75 Query: 324 LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIR 383 LAS D +W + + + T H+ VK+VAW P N+LAT + D+ + Sbjct: 76 LASASFDATTCIWK--KNQDDFECVTTLEGHENEVKSVAWAP-SGNLLATC--SRDKSVW 130 Query: 384 IWNVCS---GACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL 439 +W V C+S +++H+Q V ++W P + L S +L + A L Sbjct: 131 VWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATL 190 Query: 440 KGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 +GH S V SL P G +AS + D T+R+WR + + Sbjct: 191 EGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQG 231 Score = 162 bits (409), Expect = 4e-40, Method: Composition-based stats. Identities = 63/272 (23%), Positives = 106/272 (38%), Gaps = 34/272 (12%) Query: 190 VDWS-SGNVL-AVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247 V WS GN L + + D + +W + D + +E + SVAW GN LA + Sbjct: 67 VAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRD 126 Query: 248 AEVQLWDVQQQ---KRLRNMTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEH-H 301 V +W+V ++ + + + SH+ V + W+ +L+S S + + + Sbjct: 127 KSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVC 186 Query: 302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW-----------PSAPGEGGWVPLQT 350 ATL GH V L + P G+ LAS +D V +W + + W + T Sbjct: 187 CATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICT 246 Query: 351 FTQ-HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW----NVCSGACLSAVDAH------ 399 + H + +AWC A D IR++ N ++ AH Sbjct: 247 LSGFHSRTIYDIAWCQLTG---ALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHS 303 Query: 400 SQVCSILWSPHYKELISGHGFAQNQLVIWKYP 431 V + W+P L+ ++ WKY Sbjct: 304 QDVNCVAWNPKEPGLL-ASCSDDGEVAFWKYQ 334 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 57/282 (20%), Positives = 100/282 (35%), Gaps = 31/282 (10%) Query: 225 PGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ--QQKRLRNMT-SHSARVGSLSWNS--Y 279 P +AW G LA +++W + ++ H V ++W+ Sbjct: 15 PDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGN 74 Query: 280 ILSSGSRSGHIHHHDVRVAE-HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 L+S S + V TL GH EV + WAP G LA+ D V VW Sbjct: 75 YLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEV 134 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGA--CLSAV 396 E + + H VK V W P Q + + D ++++ C + + Sbjct: 135 -DEEDEYECVSVLNSHTQDVKHVVWHPSQELL---ASASYDDTVKLYREEEDDWVCCATL 190 Query: 397 DAH-SQVCSILWSPHYKELISGHGFAQNQLVIW---------------KYPTMAKVAELK 440 + H S V S+ + P + L S + IW P+ + L Sbjct: 191 EGHESTVWSLAFDPSGQRLASCSD--DRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLS 248 Query: 441 G-HTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRR 481 G H+ + + +A+A D+ +R+++ ++ Sbjct: 249 GFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQP 290 Score = 42.5 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 11/41 (26%), Positives = 19/41 (46%), Gaps = 1/41 (2%) Query: 431 PTMAKVAELKGH-TSRVLSLTMSPDGATVASAAADETLRLW 470 ++ + + H SR L +P G +AS D +R+W Sbjct: 3 DSLVLLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIW 43 >5YZG-W nrPDB Length = 579 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 67/392 (17%), Positives = 119/392 (30%), Gaps = 28/392 (7%) Query: 96 SKENQPENSQTPTKKEHQKAWALNLN-GFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQ 154 E +KE + A G EE + YQ R + Q Sbjct: 200 VDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQ 259 Query: 155 KATPGSSRKTCRYIPSLPDRILDAPEIRND--YYLNLVDWSSGNVLAVALDNSVYLWSAS 212 LP + + + L S +L+ ++D + LW Sbjct: 260 DVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVY 319 Query: 213 SGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVG 272 G+ L + + + + G ++LWD + + + T+ Sbjct: 320 -GERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVP-Y 377 Query: 273 SLSWNS-----YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASG 327 + +N + +G I D+R E V H V + + + R S Sbjct: 378 CVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEI-VQEYDRHLGAVNTIVFVDENRRFVST 436 Query: 328 GNDNLVNVWP-SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWN 386 +D + VW P + ++ + H AV P + + D I I+ Sbjct: 437 SDDKSLRVWEWDIPVDFKYIAEPSM--HSMP--AVTLSPNGKWL---ACQSMDNQILIFG 489 Query: 387 VCSG---ACLSAVDAH---SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK 440 + H C + +SP +ISG G +L IW + T + K Sbjct: 490 AQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDG--NGKLNIWDWKTTKLYSRFK 547 Query: 441 GHTSRVLSLTMSPDG-ATVASAAADETLRLWR 471 H + P + V + D ++LW Sbjct: 548 AHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579 Score = 84.8 bits (208), Expect = 8e-17, Method: Composition-based stats. Identities = 26/157 (16%), Positives = 55/157 (35%), Gaps = 10/157 (6%) Query: 348 LQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC-SGACLSAVDAHSQ-VCSI 405 + ++ H V AV P ++L + + D I++W V CL HS+ V I Sbjct: 281 IHVWSGHTKGVSAVRLFPLSGHLLLSC--SMDCKIKLWEVYGERRCLRTFIGHSKAVRDI 338 Query: 406 LWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDG---ATVASAA 462 ++ + +S L +W T ++ + +PD + Sbjct: 339 CFNTAGTQFLSAA--YDRYLKLWDTETGQCISRFTNRKVP-YCVKFNPDEDKQNLFVAGM 395 Query: 463 ADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR 499 +D+ + W + + +R + + + R Sbjct: 396 SDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRR 432 Score = 55.2 bits (131), Expect = 7e-08, Method: Composition-based stats. Identities = 20/103 (19%), Positives = 37/103 (35%), Gaps = 14/103 (13%) Query: 380 RHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWK-YPTMAKVA 437 + I +W+ H++ V ++ P L+ ++ +W+ Y + Sbjct: 279 KQIHVWS-----------GHTKGVSAVRLFPLSGHLLL-SCSMDCKIKLWEVYGERRCLR 326 Query: 438 ELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 GH+ V + + G SAA D L+LW R Sbjct: 327 TFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISR 369 >5Z56-q nrPDB Length = 504 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 52/239 (21%), Positives = 103/239 (43%), Gaps = 19/239 (7%) Query: 267 HSARVGS------LSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD 320 HSA + ++ + +G ++ D + +E +ATL GH+++V + + P Sbjct: 217 HSASIPGILALDLCPSDTNKILTGGADKNVVVFD-KSSEQILATLKGHTKKVTSVVFHPS 275 Query: 321 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDR 380 + S D + +W +Q H+ AV ++ +L++ + D+ Sbjct: 276 QDLVFSASPDATIRIWSVPNA----SCVQVVRAHESAVTGLSLHATGDYLLSS---SDDQ 328 Query: 381 HIRIWNVCSGACLSAVDAHSQVCSIL---WSPHYKELISGHGFAQNQLVIWKYPTMAKVA 437 + ++ +G L+ V + CS+ + P LI G G +Q+ IW VA Sbjct: 329 YWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDG--LIFGTGTMDSQIKIWDLKERTNVA 386 Query: 438 ELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQ 496 GH+ + S+ S +G +A+AA D +++LW +L + + + KS + Q Sbjct: 387 NFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQ 445 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 51/325 (15%), Positives = 114/325 (35%), Gaps = 18/325 (5%) Query: 153 SQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSAS 212 + + +Y L + I L+L + +L D +V ++ S Sbjct: 193 TVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKS 252 Query: 213 SGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVG 272 S I L ++ + ++SV + + + + A +++W V ++ + +H + V Sbjct: 253 SEQI--LATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVT 310 Query: 273 SLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQ-EVCGLRWAPDGRHLASGGN 329 LS + L S S + D++ S + ++ PDG +G Sbjct: 311 GLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTM 370 Query: 330 DNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS 389 D+ + +W + F H G + ++A+ N D +++W++ Sbjct: 371 DSQIKIWDL----KERTNVANFPGHSGPITSIAFS---ENGYYLATAADDSSVKLWDLRK 423 Query: 390 GACLSA--VDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVL 447 +D + +V S+++ L G Q+ I ++ H+ Sbjct: 424 LKNFKTLQLDNNFEVKSLIFDQSGTYL--ALGGTDVQIYI--CKQWTEILHFTEHSGLTT 479 Query: 448 SLTMSPDGATVASAAADETLRLWRC 472 + +AS D +L+ + Sbjct: 480 GVAFGHHAKFIASTGMDRSLKFYSL 504 Score = 106 bits (263), Expect = 3e-23, Method: Composition-based stats. Identities = 41/195 (21%), Positives = 65/195 (33%), Gaps = 19/195 (9%) Query: 311 EVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 369 + L P D + +GG D V V+ + + L T H V +V + P Q Sbjct: 223 GILALDLCPSDTNKILTGGADKNVVVFDKSSEQ----ILATLKGHTKKVTSVVFHPSQDL 278 Query: 370 VLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIW 428 V + + D IRIW+V + +C+ V AH S V + L+S W Sbjct: 279 VFS---ASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDD-----QYW 330 Query: 429 ---KYPTMAKVAELKGHTSRV--LSLTMSPDGATVASAAADETLRLWRCFELDPARRRER 483 T + ++ TS PDG + D +++W E Sbjct: 331 AFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPG 390 Query: 484 EKASAAKSSLIHQGI 498 + G Sbjct: 391 HSGPITSIAFSENGY 405 >6GMH-W nrPDB Length = 305 Score = 174 bits (441), Expect = 7e-44, Method: Composition-based stats. Identities = 54/283 (19%), Positives = 125/283 (44%), Gaps = 13/283 (4%) Query: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 252 +S V+ +LD+ V +W + +E + SV A + A ++L Sbjct: 31 NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90 Query: 253 WDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQ 310 WD++ K+++++ + +L++ +S L++G+ G ++ V + +L + Sbjct: 91 WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKE-YSLDTRGK 149 Query: 311 EVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370 + + ++PDG++LASG D ++N++ A G+ L T H ++++ + P + Sbjct: 150 FILSIAYSPDGKYLASGAIDGIINIFDIATGK----LLHTLEGHAMPIRSLTFSPDSQLL 205 Query: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWK 429 + + D +I+I++V + H S V ++ + P + + +W Sbjct: 206 V---TASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHF--VSSSSDKSVKVWD 260 Query: 430 YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 T V H +V + + +G+ + S D+ + ++ C Sbjct: 261 VGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDC 303 Score = 126 bits (317), Expect = 2e-29, Method: Composition-based stats. Identities = 51/275 (18%), Positives = 114/275 (41%), Gaps = 19/275 (6%) Query: 221 QMEQPGEYISSVAW----IKEGNYLAVGTSSAEVQLWDVQQQ--KRLRNMTSHSARVGSL 274 Q + + I SVAW + + G+ V++W + + ++ H V S+ Sbjct: 11 QEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSV 70 Query: 275 SWNSYI--LSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNL 332 + + +S S HI D+ + + ++ + L ++PD ++LA+G + Sbjct: 71 DISHTLPIAASSSLDAHIRLWDLENGKQ-IKSIDAGPVDAWTLAFSPDSQYLATGTHVGK 129 Query: 333 VNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGAC 392 VN++ G+ + + + ++A+ P + G D I I+++ +G Sbjct: 130 VNIFGVESGKKEY----SLDTRGKFILSIAYSPDGKYL---ASGAIDGIINIFDIATGKL 182 Query: 393 LSAVDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTM 451 L ++ H+ + S+ +SP + L++ + I+ L GH S VL++ Sbjct: 183 LHTLEGHAMPIRSLTFSPDSQLLVTASD--DGYIKIYDVQHANLAGTLSGHASWVLNVAF 240 Query: 452 SPDGATVASAAADETLRLWRCFELDPARRREREKA 486 PD S+++D+++++W + Sbjct: 241 CPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQD 275 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 38/195 (19%), Positives = 72/195 (36%), Gaps = 12/195 (6%) Query: 306 SGHSQEVCGLRWAPDGR----HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 361 H + + W + + + +G D+LV VW + HQ V +V Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQW--SLEGHQLGVVSV 70 Query: 362 AWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGF 420 + + D HIR+W++ +G + ++DA ++ +SP + L +G Sbjct: 71 DIS---HTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHV 127 Query: 421 AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 ++ I+ + K L +LS+ SPDG +AS A D + ++ Sbjct: 128 --GKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHT 185 Query: 481 REREKASAAKSSLIH 495 E + Sbjct: 186 LEGHAMPIRSLTFSP 200 Score = 67.1 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 19/149 (12%), Positives = 46/149 (30%), Gaps = 4/149 (2%) Query: 352 TQHQGAVKAVAW-CPWQSNVLATGGGTSDRHIRIWNVCSGAC--LSAVDAHSQVCSILWS 408 H A+ +VAW + N G+ D +++W +++ H Q+ + Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGH-QLGVVSVD 71 Query: 409 PHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLR 468 + I+ + +W ++ + +L SPD +A+ + Sbjct: 72 ISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVN 131 Query: 469 LWRCFELDPARRREREKASAAKSSLIHQG 497 ++ + + G Sbjct: 132 IFGVESGKKEYSLDTRGKFILSIAYSPDG 160 >4LG8-A nrPDB Length = 354 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 49/226 (21%), Positives = 99/226 (43%), Gaps = 13/226 (5%) Query: 274 LSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLV 333 ++ + +G ++ D + +E +ATL GH+++V + + P + S D + Sbjct: 80 CPSDTNKILTGGADKNVVVFD-KSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATI 138 Query: 334 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACL 393 +W +Q H+ AV ++ +L++ + D++ ++ +G L Sbjct: 139 RIWSVPNA----SCVQVVRAHESAVTGLSLHATGDYLLSS---SDDQYWAFSDIQTGRVL 191 Query: 394 SAVDAHSQVCSIL---WSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLT 450 + V + CS+ + P LI G G +Q+ IW VA GH+ + S+ Sbjct: 192 TKVTDETSGCSLTCAQFHPDG--LIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIA 249 Query: 451 MSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQ 496 S +G +A+AA D +++LW +L + + + KS + Q Sbjct: 250 FSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQ 295 Score = 156 bits (395), Expect = 2e-38, Method: Composition-based stats. Identities = 51/325 (15%), Positives = 114/325 (35%), Gaps = 18/325 (5%) Query: 153 SQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSAS 212 + + +Y L + I L+L + +L D +V ++ S Sbjct: 43 TVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKS 102 Query: 213 SGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVG 272 S I L ++ + ++SV + + + + A +++W V ++ + +H + V Sbjct: 103 SEQI--LATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVT 160 Query: 273 SLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQ-EVCGLRWAPDGRHLASGGN 329 LS + L S S + D++ S + ++ PDG +G Sbjct: 161 GLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTM 220 Query: 330 DNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS 389 D+ + +W + F H G + ++A+ N D +++W++ Sbjct: 221 DSQIKIWDL----KERTNVANFPGHSGPITSIAFS---ENGYYLATAADDSSVKLWDLRK 273 Query: 390 GACLSA--VDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVL 447 +D + +V S+++ L G Q+ I ++ H+ Sbjct: 274 LKNFKTLQLDNNFEVKSLIFDQSGTYL--ALGGTDVQIYI--CKQWTEILHFTEHSGLTT 329 Query: 448 SLTMSPDGATVASAAADETLRLWRC 472 + +AS D +L+ + Sbjct: 330 GVAFGHHAKFIASTGMDRSLKFYSL 354 Score = 104 bits (259), Expect = 1e-22, Method: Composition-based stats. Identities = 41/195 (21%), Positives = 65/195 (33%), Gaps = 19/195 (9%) Query: 311 EVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 369 + L P D + +GG D V V+ + + L T H V +V + P Q Sbjct: 73 GILALDLCPSDTNKILTGGADKNVVVFDKSSEQ----ILATLKGHTKKVTSVVFHPSQDL 128 Query: 370 VLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIW 428 V + + D IRIW+V + +C+ V AH S V + L+S W Sbjct: 129 VFS---ASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDD-----QYW 180 Query: 429 ---KYPTMAKVAELKGHTSRV--LSLTMSPDGATVASAAADETLRLWRCFELDPARRRER 483 T + ++ TS PDG + D +++W E Sbjct: 181 AFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPG 240 Query: 484 EKASAAKSSLIHQGI 498 + G Sbjct: 241 HSGPITSIAFSENGY 255 >3JB9-L nrPDB Length = 340 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 45/220 (20%), Positives = 91/220 (41%), Gaps = 10/220 (4%) Query: 264 MTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDG 321 M H+A V ++ +SG I +V + L+G + L+W+ D Sbjct: 46 MFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDS 105 Query: 322 RHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRH 381 R + +D + W + G+ ++ H G V A+ S +L + + D Sbjct: 106 RVVYCSSSDTHLMSWDAVSGQK----IRKHKGHAGVVNALDVLKVGSELLTSV--SDDCT 159 Query: 382 IRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKG 441 +++W+ S C+ ++ + ++ + ++ G + IW LKG Sbjct: 160 MKVWDSRSKDCIKTIEEKYPLTAVAIAQQGTQVFI--GGIDGAIKIWDLRNNHCSHVLKG 217 Query: 442 HTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRR 481 H + SL +S DG+++ S + D T+R++ A+R+ Sbjct: 218 HKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQ 257 Score = 171 bits (432), Expect = 8e-43, Method: Composition-based stats. Identities = 52/290 (17%), Positives = 107/290 (36%), Gaps = 25/290 (8%) Query: 190 VDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE 249 D S + +D + LW+ GD+ + I+ + W ++ + +S Sbjct: 58 FDPSGSYFASGGMDRQILLWNVF-GDVKNYGVLNGCKGAITDLQWSRDSRVVYCSSSDTH 116 Query: 250 VQLWDVQQQKRLRNMTSHSARVGSLS---WNSYILSSGSRSGHIHHHDVRVAEHHVATLS 306 + WD +++R H+ V +L S +L+S S + D R + + T+ Sbjct: 117 LMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRS-KDCIKTIE 175 Query: 307 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW 366 + + A G + GG D + +W H+ + ++A Sbjct: 176 E-KYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNH----CSHVLKGHKDIITSLAISKD 230 Query: 367 QSNVLATGGGTSDRHIRIWNV----CSGACLSAVDA-----HSQVCSILWSPHYKELISG 417 S++L+ + D +RI++V + L + + + WS + + + G Sbjct: 231 GSSLLS---NSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFV--G 285 Query: 418 HGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETL 467 G + + +W T L GH V + P + S ++D T+ Sbjct: 286 AGSSDKNVYVWSA-TGDLRYVLPGHEGSVNHVDFHPHQDIILSCSSDRTI 334 Score = 142 bits (358), Expect = 3e-34, Method: Composition-based stats. Identities = 47/208 (22%), Positives = 98/208 (47%), Gaps = 20/208 (9%) Query: 186 YLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGT 245 L+++ S + +V+ D ++ +W + S D ++ ++ + P +++VA ++G + +G Sbjct: 140 ALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIEEKYP---LTAVAIAQQGTQVFIGG 196 Query: 246 SSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVR---VAEH 300 +++WD++ + H + SL+ + L S S + DV+ A+ Sbjct: 197 IDGAIKIWDLRNNHCSHVLKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQR 256 Query: 301 HVATLS----GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG 356 + G + G+ W+ + R + +G +D V VW SA G+ +V H+G Sbjct: 257 QLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVW-SATGDLRYV----LPGHEG 311 Query: 357 AVKAVAWCPWQSNVLATGGGTSDRHIRI 384 +V V + P Q +L+ +SDR I + Sbjct: 312 SVNHVDFHPHQDIILSC---SSDRTIFL 336 Score = 104 bits (259), Expect = 1e-22, Method: Composition-based stats. Identities = 37/204 (18%), Positives = 74/204 (36%), Gaps = 9/204 (4%) Query: 296 RVAEHHVATLS--GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ 353 R ++ +V L GH+ EV R+ P G + ASGG D + +W G Sbjct: 35 RTSDLNVPNLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVF---GDVKNYGVLNG 91 Query: 354 HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKE 413 +GA+ + W V + +SD H+ W+ SG + H+ V + L Sbjct: 92 CKGAITDLQWSRDSRVVYCS---SSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGS 148 Query: 414 LISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 + + +W + + ++ + ++ ++ G V D +++W Sbjct: 149 ELLTSVSDDCTMKVWDSRSKDCIKTIE-EKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLR 207 Query: 474 ELDPARRREREKASAAKSSLIHQG 497 + + K ++ G Sbjct: 208 NNHCSHVLKGHKDIITSLAISKDG 231 Score = 96.4 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 35/216 (16%), Positives = 78/216 (36%), Gaps = 19/216 (8%) Query: 133 LSGKPQNAPEGYQNRLKVLYSQKA-----TPGSSRKTCRYIPSLPDRILDAPEIRNDYYL 187 +SG+ +G+ + L K T S T + S + E + Sbjct: 123 VSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIEEKYPLTA 182 Query: 188 NLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247 + V +D ++ +W + + ++ + I+S+A K+G+ L + Sbjct: 183 VAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHV--LKGHKDIITSLAISKDGSSLLSNSMD 240 Query: 248 AEVQLWDVQQQKRLRN--------MTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRV 297 V+++DV+ + + + ++W NS + +GS +++ Sbjct: 241 NTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSATG 300 Query: 298 AEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLV 333 +V L GH V + + P + S +D + Sbjct: 301 DLRYV--LPGHEGSVNHVDFHPHQDIILSCSSDRTI 334 Score = 66.0 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 19/127 (14%), Positives = 46/127 (36%), Gaps = 9/127 (7%) Query: 178 APEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSG----DILQLLQM--EQPGEYISS 231 ++ + ++L+ ++DN+V ++ LQ+ + + Sbjct: 215 LKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLG 274 Query: 232 VAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY--ILSSGSRSGH 289 VAW + ++ G+S V +W + H V + ++ + I+ S S Sbjct: 275 VAWSRNSRFVGAGSSDKNVYVWS-ATGDLRYVLPGHEGSVNHVDFHPHQDIILSCSSDRT 333 Query: 290 IHHHDVR 296 I ++ Sbjct: 334 IFLGELN 340 >4YCZ-A nrPDB Length = 876 Score = 173 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 55/304 (18%), Positives = 107/304 (35%), Gaps = 37/304 (12%) Query: 171 LPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYIS 230 +++ + + ++D+ + + D ++ ++ ++ + Sbjct: 7 AGTQVIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVW 66 Query: 231 SVAWIKE--GNYLAVGTSSAEVQLWDVQQQ--KRLRNMTSHSARVGSLSWNSY----ILS 282 V+W GN LA +V +W +R+ + H A V +SW+ + +L+ Sbjct: 67 CVSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLA 126 Query: 283 SGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD-----------------GRHLA 325 S G++ + R + H V + WAP R Sbjct: 127 CASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFV 186 Query: 326 SGGNDNLVNVWPSAPGEGGWVPLQ-TFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRI 384 +GG+DN + +W P + + T H V+ VAW P + DR +RI Sbjct: 187 TGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRI 246 Query: 385 W-----NVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYP---TMAKV 436 W N C ++ + V + WS L + G N++ +WK V Sbjct: 247 WTSDPANPLQWNC-KVLNFDAAVWRVSWSLSGNVLAASGG--DNKVTLWKENLKGEWECV 303 Query: 437 AELK 440 ++ Sbjct: 304 KTIE 307 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 60/245 (24%), Positives = 96/245 (39%), Gaps = 33/245 (13%) Query: 265 TSHSARVGS--LSWNSYILSSGSRSGHIHHHDVRVAEHHVA-TLSGHSQEVCGLRW-APD 320 + H + L + L++ S I ++ + TL GH V + W P Sbjct: 15 SGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPK 74 Query: 321 -GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSD 379 G LAS G D V +W G W + F H+ +V V+W P ++ L +SD Sbjct: 75 YGNILASAGYDGKVLIWRELNG--AWQRIFDFALHKASVNVVSWSPHEAGCLLACA-SSD 131 Query: 380 RHIRIWNVCSGA-CLSAVDAHS-QVCSILWSPHYK--ELISG-------------HGFAQ 422 ++ + + S AH V S+ W+P ++S G + Sbjct: 132 GNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSD 191 Query: 423 NQLVIWKYPTMAKVAELK-----GHTSRVLSLTMSP---DGATVASAAADETLRLWRCFE 474 N L IW Y +L+ GHT V + SP + +ASA+ D T+R+W Sbjct: 192 NALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDP 251 Query: 475 LDPAR 479 +P + Sbjct: 252 ANPLQ 256 Score = 131 bits (330), Expect = 5e-31, Method: Composition-based stats. Identities = 52/287 (18%), Positives = 104/287 (36%), Gaps = 36/287 (12%) Query: 218 QLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ--QQKRLRNMTSHSARVGSLS 275 Q++ + I G LA +S +++++++ Q+ + H V +S Sbjct: 10 QVIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVS 69 Query: 276 WN----SYILSSGSRSGHIHHH-DVRVAEHHVATLSGHSQEVCGLRWAPD--GRHLASGG 328 W IL+S G + ++ A + + H V + W+P G LA Sbjct: 70 WAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACAS 129 Query: 329 NDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS--NVLAT------------G 374 +D V+V F H V +V+W P S +++++ Sbjct: 130 SDGNVSVLEFRDNSWE---HSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFV 186 Query: 375 GGTSDRHIRIW--NVCSGA---CLSAVDAHSQ-VCSILWSPHY-KELISGHGFAQNQLVI 427 G SD ++IW + + + H+ V + WSP ++ + I Sbjct: 187 TGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRI 246 Query: 428 WKYPTMAKVA---ELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 W + ++ + V ++ S G +A++ D + LW+ Sbjct: 247 WTSDPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLWK 293 Score = 94.1 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 40/205 (19%), Positives = 70/205 (34%), Gaps = 26/205 (12%) Query: 307 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAW-CP 365 GH + GR LA+ +D + ++ +T H GAV V+W P Sbjct: 16 GHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLT--ETLKGHDGAVWCVSWAHP 73 Query: 366 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVD---AHSQVCSILWSPHYKELISGHGFAQ 422 N+LA+ G D + IW +GA D + V + WSPH + + Sbjct: 74 KYGNILASAG--YDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSD 131 Query: 423 NQLVIWKYPTMAKVAE-LKGHTSRVLSLTMSP-----------------DGATVASAAAD 464 + + ++ + H V S++ +P + +D Sbjct: 132 GNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSD 191 Query: 465 ETLRLWRCFELDPARRREREKASAA 489 L++W + ERE + Sbjct: 192 NALKIWAYDPATNTYKLEREPLTGH 216 Score = 35.9 bits (81), Expect = 0.040, Method: Composition-based stats. Identities = 7/44 (15%), Positives = 18/44 (40%) Query: 429 KYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 +V GH + + G +A+ ++D T++++ Sbjct: 4 SMAAGTQVIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEI 47 >4BTS-AR nrPDB Length = 343 Score = 173 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 50/304 (16%), Positives = 109/304 (35%), Gaps = 43/304 (14%) Query: 197 VLAVALDNSVYLWSASSGDILQLL-----QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQ 251 +++ + D +V +W + + ++S +A +E + + ++ Sbjct: 42 LISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSSWDKTLR 101 Query: 252 LWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATL-SGH 308 LWD++ + H + V S+++ ++ + S I ++ + H Sbjct: 102 LWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGECKFSSAEKENH 161 Query: 309 SQEVCGLRWA----------PDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAV 358 S V +R++ P + AS G D + VW + + TF H+ V Sbjct: 162 SDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNT-----NFQIRYTFKAHESNV 216 Query: 359 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGAC-LSAVDAHSQVCSILWSPHYKELISG 417 ++ P + G D+ + IW++ + DA S + I ++P + + G Sbjct: 217 NHLSISPNGKYI---ATGGKDKKLLIWDILNLTYPQREFDAGSTINQIAFNPKLQWVAVG 273 Query: 418 HGFAQNQLVIWKY--PTMAKVAEL-----------KGHTSRVLSLTMSPDGATVASAAAD 464 + I+ + A V + KG + SL + G + + D Sbjct: 274 ---TDQGVKIFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFAGFTD 330 Query: 465 ETLR 468 +R Sbjct: 331 GVIR 334 Score = 171 bits (433), Expect = 7e-43, Method: Composition-based stats. Identities = 55/259 (21%), Positives = 95/259 (36%), Gaps = 35/259 (13%) Query: 263 NMTSHSARVGSL--------SWNSYILSSGSRSGHIHHHDVRVAEHH------VATLSGH 308 + HS V S+ + +S +L SGSR + + E + L+GH Sbjct: 16 ILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGH 75 Query: 309 SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS 368 + V L + + S D + +W G + F HQ V +VA+ P Sbjct: 76 NHFVSDLALSQENCFAISSSWDKTLRLWDLRTGT----TYKRFVGHQSEVYSVAFSPDNR 131 Query: 369 NVLATGGGTSDRHIRIWNVCSGAC----LSAVDAHSQVCSILWSPHYKE--------LIS 416 +L+ G +R I++WN+ G C + V + +SP K Sbjct: 132 QILSAGA---EREIKLWNIL-GECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYF 187 Query: 417 GHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELD 476 +L +W K H S V L++SP+G +A+ D+ L +W L Sbjct: 188 ASVGWDGRLKVWNT-NFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDILNLT 246 Query: 477 PARRREREKASAAKSSLIH 495 +R ++ + + Sbjct: 247 YPQREFDAGSTINQIAFNP 265 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 55/303 (18%), Positives = 111/303 (36%), Gaps = 42/303 (13%) Query: 222 MEQPGEYISSVAW------IKEGNYLAVGTSSAEVQLWDVQQQK-------RLRNMTSHS 268 +E ++++S+ ++ L G+ V +W + +++ + +T H+ Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHN 76 Query: 269 ARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLAS 326 V L+ + S S + D+R + GH EV + ++PD R + S Sbjct: 77 HFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTY-KRFVGHQSEVYSVAFSPDNRQILS 135 Query: 327 GGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP-----WQSNVLATGGGTS--D 379 G + + +W GE + + H V V + P + A + D Sbjct: 136 AGAEREIKLWNIL-GECKFSSAEK-ENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWD 193 Query: 380 RHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA-KVA 437 +++WN + AH S V + SP+ K + G +L+IW + Sbjct: 194 GRLKVWNT-NFQIRYTFKAHESNVNHLSISPNGKYI--ATGGKDKKLLIWDILNLTYPQR 250 Query: 438 ELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF----------ELDPARRREREKAS 487 E S + + +P VA D+ ++++ E +P + E +K Sbjct: 251 EFDA-GSTINQIAFNPKLQWVAVG-TDQGVKIFNLMTQSKAPVCTIEAEPITKAEGQKGK 308 Query: 488 AAK 490 + Sbjct: 309 NPQ 311 Score = 91.0 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 40/292 (13%), Positives = 92/292 (31%), Gaps = 29/292 (9%) Query: 123 FDVEEAKILRLSGKPQNAPEGYQNRLKV-LYSQKATPGSSRKTCRYIP-SLPDRILDAPE 180 ++ E+ + K + + L + + A S KT R Sbjct: 57 YEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVG 116 Query: 181 IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWI----- 235 +++ Y + +L+ + + LW+ + E +++S V + Sbjct: 117 HQSEVYSVAFSPDNRQILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKS 176 Query: 236 -----KEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSG 288 Y A +++W+ + +H + V LS N +++G + Sbjct: 177 ANKVQPFAPYFASVGWDGRLKVWNT-NFQIRYTFKAHESNVNHLSISPNGKYIATGGKDK 235 Query: 289 HIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVP- 347 + D+ + + + + P + +A G D V ++ V Sbjct: 236 KLLIWDILNLTYPQREFDA-GSTINQIAFNPKLQWVA-VGTDQGVKIFNLMTQSKAPVCT 293 Query: 348 -----LQTFTQHQG---AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGA 391 + +G ++AW + A G +D IR ++ + A Sbjct: 294 IEAEPITKAEGQKGKNPQCTSLAWNALGKKLFA---GFTDGVIRTFSFETSA 342 Score = 90.6 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 30/159 (18%), Positives = 52/159 (32%), Gaps = 11/159 (6%) Query: 337 PSAPGEGGWVPLQTFTQHQGAVKAVA---WCPWQSNVLATGGGTSDRHIRIWNVCS---- 389 ++ + V H V ++ + G+ D+ + IW + Sbjct: 3 DNSSLDIQVVKRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQN 62 Query: 390 ---GACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRV 446 G A+ H+ S L + + + L +W T GH S V Sbjct: 63 GYFGIPHKALTGHNHFVSDL-ALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEV 121 Query: 447 LSLTMSPDGATVASAAADETLRLWRCFELDPARRREREK 485 S+ SPD + SA A+ ++LW E+E Sbjct: 122 YSVAFSPDNRQILSAGAEREIKLWNILGECKFSSAEKEN 160 >5GAN-H nrPDB Length = 465 Score = 172 bits (436), Expect = 3e-43, Method: Composition-based stats. Identities = 58/293 (19%), Positives = 114/293 (38%), Gaps = 27/293 (9%) Query: 198 LAVALDNSVYLWSASSGDILQLL---------QMEQPGEYISSVAWIKEGN-YLAVGTSS 247 ++++ D+ V + +GD+ L +++ I ++ W + N + Sbjct: 181 VSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAED 240 Query: 248 AEVQLWDVQQQK----RLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHH 301 ++ + ++ L ++ H R+ + ++ + S S D Sbjct: 241 GLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDAST-HQE 299 Query: 302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 361 + GH + V L + DG + SGG D+L +W G + T H + V Sbjct: 300 LLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSK----VMTLAGHSKPIYTV 355 Query: 362 AWCPWQSNVLATGGGTSDRHIRIWNVC---SGACLSAVDAHSQVCSILWSPHYKELISGH 418 AW P +ATGGG D I +W++ G + + V + +S Sbjct: 356 AWSP-NGYQVATGGG--DGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVS 412 Query: 419 GFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 N + ++ T K+ L GHT +++SL +S + + S D +++LW Sbjct: 413 CGYDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 148 bits (374), Expect = 4e-36, Method: Composition-based stats. Identities = 44/209 (21%), Positives = 88/209 (42%), Gaps = 7/209 (3%) Query: 273 SLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD-GRHLASGGNDN 331 SLS + ++++GS +G + + + + L H ++ + W PD + S D Sbjct: 182 SLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDG 241 Query: 332 LVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGA 391 L+ + + EGG L H+ + V + P G + D R+W+ + Sbjct: 242 LIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGK---FIGSASHDMTWRLWDASTHQ 298 Query: 392 CLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLT 450 L + H + V S+ + + G + ++W + +KV L GH+ + ++ Sbjct: 299 ELLLQEGHDKGVFSLSFQCDGS--LVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVA 356 Query: 451 MSPDGATVASAAADETLRLWRCFELDPAR 479 SP+G VA+ D + +W + D + Sbjct: 357 WSPNGYQVATGGGDGIINVWDIRKRDEGQ 385 Score = 147 bits (371), Expect = 9e-36, Method: Composition-based stats. Identities = 45/258 (17%), Positives = 113/258 (43%), Gaps = 21/258 (8%) Query: 225 PGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRL-RNMTSHSARVGSLSWNS---YI 280 + IS+V+ + +A G+ + ++Q+ + Q + L + + SH ++G++ W+ Sbjct: 174 STKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQ 233 Query: 281 LSSGSRSGHIHHH---DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP 337 + S + G I + + + L GH + + +++ P G+ + S +D +W Sbjct: 234 MISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWD 293 Query: 338 SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVD 397 ++ + + H V ++++ S G D +W++ SG+ + + Sbjct: 294 ASTHQELLLQ----EGHDKGVFSLSFQCDGS---LVCSGGMDSLSMLWDIRSGSKVMTLA 346 Query: 398 AHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMA--KVAELKGHTSRVLSLTMSPD 454 HS+ + ++ WSP+ ++ +G G + +W ++ ++ H + V + S + Sbjct: 347 GHSKPIYTVAWSPNGYQVATGGG--DGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKE 404 Query: 455 --GATVASAAADETLRLW 470 G + S D + ++ Sbjct: 405 DGGKKLVSCGYDNLINVY 422 Score = 84.8 bits (208), Expect = 7e-17, Method: Composition-based stats. Identities = 34/196 (17%), Positives = 65/196 (33%), Gaps = 12/196 (6%) Query: 309 SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS 368 ++ + + + D +A+G + V S + Q H G + A+ W P + Sbjct: 175 TKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQP---LTQKLDSHVGKIGAIDWHPDSN 231 Query: 369 NVLATGGGTSDRHIRIWNVCSGA----CLSAVDAHSQ-VCSILWSPHYKELISGHGFAQN 423 N + + D I+ + + L + H + + + + P K + G Sbjct: 232 NQMISCA--EDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFI--GSASHDM 287 Query: 424 QLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRRER 483 +W T ++ +GH V SL+ DG+ V S D LW Sbjct: 288 TWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAG 347 Query: 484 EKASAAKSSLIHQGIR 499 + G + Sbjct: 348 HSKPIYTVAWSPNGYQ 363 >5Y1U-A nrPDB Length = 456 Score = 172 bits (436), Expect = 3e-43, Method: Composition-based stats. Identities = 62/284 (21%), Positives = 114/284 (40%), Gaps = 32/284 (11%) Query: 235 IKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIH 291 ++G + G+ S ++++ ++ +H V + N I+++ + S + Sbjct: 131 SEKGEFGGFGSVSGKIEI-------EIKI--NHEGEVNRARYMPQNPCIIATKTPSSDVL 181 Query: 292 HHDV---------RVAEHHVATLSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWP--SA 339 D + L GH +E GL W P+ HL S +D+ + +W + Sbjct: 182 VFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAV 241 Query: 340 PGEGGWVPLQT-FTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS---A 395 P EG V +T FT H V+ V+W ++ G D+ + IW+ S + Sbjct: 242 PKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLF--GSVADDQKLMIWDTRSNNTSKPSHS 299 Query: 396 VDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA-KVAELKGHTSRVLSLTMSP- 453 VDAH+ + L Y E I G A + +W + K+ + H + + SP Sbjct: 300 VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPH 359 Query: 454 DGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 + +AS+ D L +W ++ + E + + IH G Sbjct: 360 NETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGG 403 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 69/359 (19%), Positives = 130/359 (36%), Gaps = 45/359 (12%) Query: 72 SKPGGDRYIPHR---SAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEA 128 ++P G + HR + + L+ Q N H + GF Sbjct: 85 TRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSG 144 Query: 129 KILRLSGKPQNAPEGYQNRLKVLYSQK----ATPGSSRKTCRYIPSLPDRILDAPEIRND 184 KI + + EG NR + + SS P + + E D Sbjct: 145 KIE---IEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPD 201 Query: 185 YYLNL-------VDWS---SGNVLAVALDNSVYLWSASS----GDILQLLQ-MEQPGEYI 229 L + W+ SG++L+ + D+++ LW S+ G ++ + Sbjct: 202 LRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVV 261 Query: 230 SSVAWIK-EGNYLAVGTSSAEVQLWDVQ---QQKRLRNMTSHSARVGSLSWNSY---ILS 282 V+W + ++ +WD + K ++ +H+A V LS+N Y IL+ Sbjct: 262 EDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 321 Query: 283 SGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAP- 340 +GS + D+R + + + H E+ ++W+P + LAS G D +NVW + Sbjct: 322 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 381 Query: 341 ---------GEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG 390 +G L H + +W P + V+ + D +++W + Sbjct: 382 GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVI--CSVSEDNIMQVWQMAEN 438 Score = 145 bits (365), Expect = 5e-35, Method: Composition-based stats. Identities = 49/289 (16%), Positives = 111/289 (38%), Gaps = 42/289 (14%) Query: 224 QPGEYISSVAWIKEG-NYLAVGTSSAEVQLWDVQ----------QQKRLRNMTSHSARVG 272 ++ ++ + +A T S++V ++D + + H Sbjct: 153 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 212 Query: 273 SLSWNSYI---LSSGSRSGHIHHHDVRVAEHHVA------TLSGHSQEVCGLRWAP-DGR 322 LSWN + L S S I D+ +GH+ V + W Sbjct: 213 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 272 Query: 323 HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHI 382 S +D + +W + P + H V +++ P+ +LAT G++D+ + Sbjct: 273 LFGSVADDQKLMIWDTRSN-NTSKPSHSVDAHTAEVNCLSFNPYSEFILAT--GSADKTV 329 Query: 383 RIWNVCSGA-CLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK 440 +W++ + L + ++H ++ + WSPH + +++ G +L +W + + + Sbjct: 330 ALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG-TDRRLNVWDLSKIGEEQSPE 388 Query: 441 --------------GHTSRVLSLTMSPDGAT-VASAAADETLRLWRCFE 474 GHT+++ + +P+ + S + D +++W+ E Sbjct: 389 DAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 437 >3C9C-A nrPDB Length = 432 Score = 171 bits (434), Expect = 5e-43, Method: Composition-based stats. Identities = 56/284 (19%), Positives = 110/284 (38%), Gaps = 32/284 (11%) Query: 235 IKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIH 291 ++G + G+ ++++ ++ +H V + N+ ++++ + S + Sbjct: 106 NEKGEFGGFGSVCGKIEI-------EIKI--NHEGEVNRARYMPQNACVIATKTPSSDVL 156 Query: 292 HHDV---------RVAEHHVATLSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWP--SA 339 D L GH +E GL W P+ +L S +D+ + +W + Sbjct: 157 VFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINAT 216 Query: 340 PGEGGWVPLQT-FTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS---A 395 P E + + FT H V+ VAW ++ G D+ + IW+ + Sbjct: 217 PKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLF--GSVADDQKLMIWDTRNNNTSKPSHT 274 Query: 396 VDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA-KVAELKGHTSRVLSLTMSP- 453 VDAH+ + L Y E I G A + +W + K+ + H + + SP Sbjct: 275 VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPH 334 Query: 454 DGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 + +AS+ D L +W ++ + E + + IH G Sbjct: 335 NETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGG 378 Score = 153 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 43/227 (18%), Positives = 91/227 (40%), Gaps = 28/227 (12%) Query: 190 VDWS---SGNVLAVALDNSVYLWSASSGDILQLLQ-----MEQPGEYISSVAWIK-EGNY 240 + W+ +G +L+ + D+++ LW ++ + + VAW + Sbjct: 189 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 248 Query: 241 LAVGTSSAEVQLWDVQ---QQKRLRNMTSHSARVGSLSWNSY---ILSSGSRSGHIHHHD 294 ++ +WD + K + +H+A V LS+N Y IL++GS + D Sbjct: 249 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 308 Query: 295 VRVAEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAP----------GEG 343 +R + + + H E+ ++W+P + LAS G D ++VW + +G Sbjct: 309 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 368 Query: 344 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG 390 L H + +W P + ++ + D +++W + Sbjct: 369 PPELLFIHGGHTAKISDFSWNPNEPWII--CSVSEDNIMQVWQMAEN 413 Score = 148 bits (372), Expect = 8e-36, Method: Composition-based stats. Identities = 50/289 (17%), Positives = 112/289 (38%), Gaps = 42/289 (14%) Query: 224 QPGEYISSVAWIKEG-NYLAVGTSSAEVQLWDVQ----------QQKRLRNMTSHSARVG 272 ++ ++ + +A T S++V ++D + + + H Sbjct: 128 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 187 Query: 273 SLSWNSYI---LSSGSRSGHIHHHDVRVAEHHVA------TLSGHSQEVCGLRWAP-DGR 322 LSWN + L S S I D+ +GH+ V + W Sbjct: 188 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 247 Query: 323 HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHI 382 S +D + +W + P T H V +++ P+ +LAT G++D+ + Sbjct: 248 LFGSVADDQKLMIWDTRNN-NTSKPSHTVDAHTAEVNCLSFNPYSEFILAT--GSADKTV 304 Query: 383 RIWNVCSGA-CLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK 440 +W++ + L + ++H ++ + WSPH + +++ G +L +W + + + Sbjct: 305 ALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG-TDRRLHVWDLSKIGEEQSTE 363 Query: 441 --------------GHTSRVLSLTMSPDGAT-VASAAADETLRLWRCFE 474 GHT+++ + +P+ + S + D +++W+ E Sbjct: 364 DAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 412 >2HES-X nrPDB Length = 330 Score = 171 bits (434), Expect = 5e-43, Method: Composition-based stats. Identities = 63/319 (19%), Positives = 115/319 (36%), Gaps = 44/319 (13%) Query: 190 VDWSSGNVLAVALDNSVYLWSASSGDI--LQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247 D+S G + + D + L S D + +L + I SVAW + LA G+ Sbjct: 20 FDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFD 79 Query: 248 AEVQLWDVQQQ-------KRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDV--- 295 + V +W ++ L + H V ++W + Y L++ SR + + Sbjct: 80 STVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDES 139 Query: 296 RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQ 355 ++ L HSQ+V + W P LAS D+ V +W + W + H+ Sbjct: 140 GEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDD--WECVAVLNGHE 197 Query: 356 GAVKAVAWCPWQSNVLATGGGTSDRHIRIW--------NVCSGACLSAV-DAHS-QVCSI 405 G V + + + V G+ D +R+W + C + + D H QV ++ Sbjct: 198 GTVWSSDFDKTEG-VFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNV 256 Query: 406 LWSPHYKELISGHGFAQNQLVI-------WKYPTMAKVAELKGHT-SRVLSLTMSP-DGA 456 W + + A L + WK + H + + +G Sbjct: 257 AWGFNG---LIASVGADGVLAVYEEVDGEWKVFAKRALC----HGVYEINVVKWLELNGK 309 Query: 457 -TVASAAADETLRLWRCFE 474 +A+ D + W + Sbjct: 310 TILATGGDDGIVNFWSLEK 328 Score = 144 bits (363), Expect = 9e-35, Method: Composition-based stats. Identities = 54/242 (22%), Positives = 96/242 (39%), Gaps = 20/242 (8%) Query: 256 QQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATL---SGHSQEV 312 ++++ + ++ S ++ IL++GS I V+ + + + + H + + Sbjct: 2 ASINLIKSLKLYKEKIWSFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAI 61 Query: 313 CGLRWAPDGRHLASGGNDNLVNVW---PSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 369 + W P LA+G D+ V++W SA L H+ VK VAW Sbjct: 62 RSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYY 121 Query: 370 VLATGGGTSDRHIRIWNVCSG----ACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQ 424 + + D+ + IW C+S + HSQ V ++W P E + + Sbjct: 122 L---ATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPS--EALLASSSYDDT 176 Query: 425 LVIWKY--PTMAKVAELKGHTSRVLSLTMSPDGA--TVASAAADETLRLWRCFELDPARR 480 + IWK VA L GH V S + S + D T+R+W+ D + Sbjct: 177 VRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQ 236 Query: 481 RE 482 +E Sbjct: 237 QE 238 Score = 141 bits (356), Expect = 6e-34, Method: Composition-based stats. Identities = 59/288 (20%), Positives = 116/288 (40%), Gaps = 30/288 (10%) Query: 221 QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL----WDVQQQKRLRNMTSHSARVGSLSW 276 ++ E I S + + LA G++ +++L +D + + T+H + S++W Sbjct: 9 SLKLYKEKIWSFDFSQG--ILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAW 66 Query: 277 NSY--ILSSGSRSGHIHHH------DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGG 328 + +L++GS + D +A + GH EV G+ W+ DG +LA+ Sbjct: 67 RPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCS 126 Query: 329 NDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC 388 D V +W + + + +H VK V W P ++ + ++ + D +RIW Sbjct: 127 RDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASS---SYDDTVRIWKDY 183 Query: 389 --SGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKY--------PTMAKVA 437 C++ ++ H V S + G + + +WKY A Sbjct: 184 DDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEA 243 Query: 438 ELKG-HTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRRERE 484 L H +V ++ +G +AS AD L ++ + + +R Sbjct: 244 ILPDVHKRQVYNVAWGFNG-LIASVGADGVLAVYEEVDGEWKVFAKRA 290 Score = 128 bits (322), Expect = 5e-30, Method: Composition-based stats. Identities = 57/306 (18%), Positives = 105/306 (34%), Gaps = 33/306 (10%) Query: 158 PGSSRKTCRYIPSLPDRIL---DAPEIRNDYYLNLVDWSSGN--VLAVALDNSVYLWSAS 212 GS+ + + + D E + + V W + A + D++V +W+ Sbjct: 29 TGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKE 88 Query: 213 -----SGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQ----KRLRN 263 + ++ L +E + VAW +G YLA + V +W+ + + + Sbjct: 89 ESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISV 148 Query: 264 MTSHSARVGSLSWNSY--ILSSGSRSGHIHHH-DVRVAEHHVATLSGHSQEVCGLRWAPD 320 + HS V + W+ +L+S S + D VA L+GH V + Sbjct: 149 LQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKT 208 Query: 321 GR--HLASGGNDNLVNVW----PSAPGEGGWVPLQTFTQ-HQGAVKAVAWCPWQSNVLAT 373 L SG +D+ V VW + WV H+ V VAW + + + Sbjct: 209 EGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAW-GFNGLIASV 267 Query: 374 GGGTSDRHIRIWNVCSGA-----CLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIW 428 G D + ++ G + ++ + W + I G + W Sbjct: 268 GA---DGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGIVNFW 324 Query: 429 KYPTMA 434 A Sbjct: 325 SLEKAA 330 >5OQL-L nrPDB Length = 557 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 51/246 (20%), Positives = 101/246 (41%), Gaps = 14/246 (5%) Query: 232 VAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGS--LSWNSYILSSGSRSGH 289 VA K + AV T+ V+++ +++++ L+ + + + + +L +G +G Sbjct: 64 VAAAKTNDLFAV-TAGPRVEIFSIRKREPLKTIGRFDSEAHCGEIRPDGRVLVAGEDTGR 122 Query: 290 IHHHDVRVAEHHVA--TLSGHSQEVCGLRWAPDG-RHLASGGNDNLVNVWPSAPGEGGWV 346 + DV V T H Q V +W+P L S +D V +W + Sbjct: 123 MQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSND---- 178 Query: 347 PLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAVDAHSQVCSI 405 P + FT H V+ A+ P +N G+ D +R+W+ + G + + + Sbjct: 179 PTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIEDV 238 Query: 406 LWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADE 465 L P L++ G N + + + + H V SL+++ G V S + D Sbjct: 239 LPLPSGTTLLAASG---NAISVLDLVAAKPLRLITNHQKTVTSLSLASQGRRVVSGSLDG 295 Query: 466 TLRLWR 471 ++++ Sbjct: 296 HVKVFE 301 Score = 116 bits (291), Expect = 2e-26, Method: Composition-based stats. Identities = 48/238 (20%), Positives = 85/238 (35%), Gaps = 22/238 (9%) Query: 193 SSGNVLAVALD-NSVYLWSASSG-DILQLLQMEQPGEYISSVAWIKEG-NYLAVGTSSAE 249 G VL D + ++ G + L + + W L + Sbjct: 109 PDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKT 168 Query: 250 VQLWDVQQQKRLRNMTSHSARVGSLSW-----NSYILSSGSRSGHIHHHDVRVAEHHVAT 304 V+LWD+ R T H+ V ++ NS +L SGS + D R V T Sbjct: 169 VRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMT 228 Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 H+ + + P G L + N ++V + PL+ T HQ V +++ Sbjct: 229 FK-HADPIEDVLPLPSGTTLLAASG-NAISVLDLVAAK----PLRLITNHQKTVTSLSLA 282 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILW-----SPHYKELISG 417 V++ G+ D H++++ S ++ S + S+ S + L G Sbjct: 283 SQGRRVVS---GSLDGHVKVFETTSWNVVAGAKYPSPILSLSVITAGASHDDRHLAVG 337 Score = 77.1 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 35/188 (18%), Positives = 59/188 (31%), Gaps = 19/188 (10%) Query: 319 PDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTS 378 + + G V ++ E PL+T + P ++A G Sbjct: 69 TNDLFAVTAG--PRVEIFSIRKRE----PLKTIGRFDSEAHCGEIRPDGRVLVA---GED 119 Query: 379 DRHIRIWNVCSGA---CLSAVDAHSQ-VCSILWSPHY-KELISGHGFAQNQLVIWKYPTM 433 +++++V G L H Q V WSP L+S + +W P+ Sbjct: 120 TGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSD--DKTVRLWDLPSN 177 Query: 434 AKVAELKGHTSRVLSLTM---SPDGATVASAAADETLRLWRCFELDPARRREREKASAAK 490 GHT V S + + S + DET+R+W A + Sbjct: 178 DPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIED 237 Query: 491 SSLIHQGI 498 + G Sbjct: 238 VLPLPSGT 245 >6Q8F-A nrPDB Length = 514 Score = 169 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 75/423 (17%), Positives = 153/423 (36%), Gaps = 37/423 (8%) Query: 68 QTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEE 127 QT P +RYI + S+ +E P+ S K++ + A A L G +V Sbjct: 109 QTQP-----ERYI---HLENLLARSYFDPREAYPDGSS---KEKRRAAIAQALAG-EVSV 156 Query: 128 AKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIP--SLPDRILDAPEIRNDY 185 RL A + Q++ + + + + P ++ + Sbjct: 157 VPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKS 216 Query: 186 YLNLVDWSSG--NVLAVALDNSVYLWSASSGDILQLLQMEQPGEY------ISSVAWIKE 237 ++ +S ++ ++D + +W+ ++G I + L+ + + + + + ++ Sbjct: 217 HVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRD 276 Query: 238 GNYLAVGTSSAEVQLWDVQQQKRLRNMT-SHSARVGSLSW--NSYILSSGSRSGHIHHHD 294 LA G ++++W +Q + LR +HS V LS+ +S + S S I H Sbjct: 277 TEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHG 336 Query: 295 VRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEG--GWVPLQTFT 352 ++ + + GHS V + DG ++ S +D V +W E + L + Sbjct: 337 LKSGK-TLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTA 395 Query: 353 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS----QVCSILWS 408 V +V P + + I N+ G + + + S Sbjct: 396 GTDITVNSVILLPKNPEHFVVCNRS--NTVVIMNMQ-GQIVRSFSSGKREGGDFVCCALS 452 Query: 409 PHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLR 468 P + + L + T L H V+ + P +A+ + D L+ Sbjct: 453 PRGEWIYCVG--EDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLK 510 Query: 469 LWR 471 LW+ Sbjct: 511 LWK 513 Score = 149 bits (376), Expect = 3e-36, Method: Composition-based stats. Identities = 46/180 (25%), Positives = 82/180 (45%), Gaps = 11/180 (6%) Query: 307 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPG----EGGWVPLQTFTQHQGAVKAVA 362 G V R++PDG++L +G D + VW G + + F AV + Sbjct: 213 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 272 Query: 363 WCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVD-AHSQ-VCSILWSPHYKELISGHGF 420 + + +LAT G D I++W + SG CL + AHS+ V + +S +++S Sbjct: 273 FS-RDTEMLAT--GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSAS-- 327 Query: 421 AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 + I + + E +GH+S V T + DG + SA++D T+++W + + Sbjct: 328 FDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNT 387 Score = 89.8 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 25/155 (16%), Positives = 56/155 (36%), Gaps = 15/155 (9%) Query: 353 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA---------HSQVC 403 + V+ + P ++ G+ D I +WN +G + V Sbjct: 213 GQKSHVECARFSPDGQYLV---TGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVL 269 Query: 404 SILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK-GHTSRVLSLTMSPDGATVASAA 462 + +S + L G ++ +WK + + + H+ V L+ S D + + SA+ Sbjct: 270 CMCFSRDTEML--ATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSAS 327 Query: 463 ADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 D+T+R+ + + +++ G Sbjct: 328 FDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDG 362 >5FVM-C nrPDB Length = 303 Score = 168 bits (424), Expect = 7e-42, Method: Composition-based stats. Identities = 48/244 (19%), Positives = 91/244 (37%), Gaps = 18/244 (7%) Query: 240 YLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRV 297 LA ++ W+ R + ++V L + L++ H+ +D+R Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHL-HVRLYDIRS 62 Query: 298 AE-HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG 356 + V++ GH V + + + R + S D + VW +Q +H Sbjct: 63 NNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRS-----PSVQRNYKHNA 117 Query: 357 AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELIS 416 V VA P Q +++ D +IRIW++ C + + S + Sbjct: 118 PVNEVAIHPNQGELISCD---QDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSML 174 Query: 417 GHGFAQNQLVIW------KYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 G + +W T+ V + K HT + + +S D +A+ +AD T R+W Sbjct: 175 VAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVW 234 Query: 471 RCFE 474 + Sbjct: 235 NIED 238 Score = 138 bits (348), Expect = 5e-33, Method: Composition-based stats. Identities = 58/298 (19%), Positives = 109/298 (36%), Gaps = 12/298 (4%) Query: 161 SRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLL 220 T R+ +L + + L S LA A V L+ S + + Sbjct: 10 YDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHLHVRLYDIRSNNPNPVS 69 Query: 221 QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYI 280 E ++S+A+ +E ++ + +++WDV+ RN H+A V ++ + Sbjct: 70 SFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK-HNAPVNEVAIHPNQ 128 Query: 281 --LSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW-- 336 L S + G+I D+ + + + L A DG L +G N VW Sbjct: 129 GELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWRM 188 Query: 337 PSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACL-SA 395 P P+ F H + V N+ ++D R+WN+ L + Sbjct: 189 PHHTDASTLEPVTKFKSHTKYITRVLLSADVKNL---ATCSADHTARVWNIEDNYQLETT 245 Query: 396 VDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMS 452 +D H V +S L++ + + + +W T V + GH + + ++ Sbjct: 246 LDGHQRWVWDCAFSADSAYLVTA--CSDHYVRLWDLSTSEIVRQYGGHHKGAVCVALN 301 Score = 111 bits (278), Expect = 7e-25, Method: Composition-based stats. Identities = 41/206 (19%), Positives = 81/206 (39%), Gaps = 10/206 (4%) Query: 278 SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP 337 S IL+S I + T+ +V L D ++LA+ G+ V ++ Sbjct: 2 SVILASAGYDHTIRFWEALTG-VCSRTIQHADSQVNRLEITSDKKYLAAAGH-LHVRLYD 59 Query: 338 SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVD 397 P+ +F H+G V ++A+ ++++ + D I++W+V S + Sbjct: 60 IRSNN--PNPVSSFEGHKGNVTSIAFQQENRWMVSS---SEDGTIKVWDVRSPSVQRNYK 114 Query: 398 AHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSR-VLSLTMSPDGA 456 ++ V + P+ ELIS + IW +L + + SL+++ DG+ Sbjct: 115 HNAPVNEVAIHPNQGELISC--DQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGS 172 Query: 457 TVASAAADETLRLWRCFELDPARRRE 482 + + +WR A E Sbjct: 173 MLVAGNNKGNCYVWRMPHHTDASTLE 198 Score = 88.7 bits (218), Expect = 5e-18, Method: Composition-based stats. Identities = 33/172 (19%), Positives = 66/172 (38%), Gaps = 14/172 (8%) Query: 324 LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIR 383 LAS G D+ + W + G V +T V + + + A G H+R Sbjct: 5 LASAGYDHTIRFWEALTG----VCSRTIQHADSQVNRLEITSDKKYLAAAGHL----HVR 56 Query: 384 IWNVCSGAC--LSAVDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK 440 ++++ S +S+ + H V SI + + ++S + +W + + K Sbjct: 57 LYDIRSNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSS--EDGTIKVWDVRSPSVQRNYK 114 Query: 441 GHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSS 492 H + V + + P+ + S D +R+W E + E + +S Sbjct: 115 -HNAPVNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSL 165 Score = 71.0 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 25/128 (19%), Positives = 49/128 (38%), Gaps = 8/128 (6%) Query: 371 LATGGGTSDRHIRIWNVCSGACLSAVD-AHSQVCSILWSPHYKELISGHGFAQNQLVIWK 429 + D IR W +G C + A SQV + + K L + + ++ Sbjct: 3 VILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHL---HVRLYD 59 Query: 430 YPTMAK--VAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKAS 487 + V+ +GH V S+ + + S++ D T+++W P+ +R + + Sbjct: 60 IRSNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVR--SPSVQRNYKHNA 117 Query: 488 AAKSSLIH 495 IH Sbjct: 118 PVNEVAIH 125 Score = 66.0 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 14/83 (16%), Positives = 33/83 (39%), Gaps = 1/83 (1%) Query: 196 NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV 255 N+ + D++ +W+ + ++ ++ A+ + YL S V+LWD+ Sbjct: 221 NLATCSADHTARVWNIE-DNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDL 279 Query: 256 QQQKRLRNMTSHSARVGSLSWNS 278 + +R H ++ N Sbjct: 280 STSEIVRQYGGHHKGAVCVALND 302 >3CFV-B nrPDB Length = 414 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 56/252 (22%), Positives = 94/252 (37%), Gaps = 23/252 (9%) Query: 267 HSARVGSLSW---NSYILSSGSRSGHIHHHDV---------RVAEHHVATLSGHSQEVCG 314 H V + N +I+++ + S + D + L GH +E G Sbjct: 125 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 184 Query: 315 LRWAPD-GRHLASGGNDNLVNVWPSAPGEGGWVPL---QTFTQHQGAVKAVAWCPWQSNV 370 L W + HL S +D+ V +W G + FT H V+ VAW ++ Sbjct: 185 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 244 Query: 371 LATGGGTSDRHIRIWNVCSGACLSA---VDAHSQVCSILWSPHYKELISGHGFAQNQLVI 427 G D+ + IW+ S VDAH+ + L Y E I G A + + Sbjct: 245 F--GSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 302 Query: 428 WKYPTMA-KVAELKGHTSRVLSLTMSP-DGATVASAAADETLRLWRCFELDPARRREREK 485 W + K+ + H + + SP + +AS+ D L +W ++ + E + Sbjct: 303 WDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAE 362 Query: 486 ASAAKSSLIHQG 497 + IH G Sbjct: 363 DGPPELLFIHGG 374 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 49/220 (22%), Positives = 89/220 (40%), Gaps = 25/220 (11%) Query: 194 SGNVLAVALDNSVYLWSASSGDILQLLQ-----MEQPGEYISSVAWIK-EGNYLAVGTSS 247 SG++L+ + D++V LW ++G + + VAW + Sbjct: 192 SGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADD 251 Query: 248 AEVQLWDVQ---QQKRLRNMTSHSARVGSLSWNSY---ILSSGSRSGHIHHHDVRVAEHH 301 ++ +WD + K + +H+A V LS+N Y IL++GS + D+R + Sbjct: 252 QKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK 311 Query: 302 VATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAP----------GEGGWVPLQT 350 + T H E+ + W+P + LAS G D +NVW + +G L Sbjct: 312 LHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFI 371 Query: 351 FTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG 390 H + +W P + V+ + D ++IW + Sbjct: 372 HGGHTAKISDFSWNPNEPWVI--CSVSEDNIMQIWQMAEN 409 Score = 148 bits (372), Expect = 7e-36, Method: Composition-based stats. Identities = 53/300 (17%), Positives = 118/300 (39%), Gaps = 43/300 (14%) Query: 213 SGDILQLLQMEQPGEYISSVAWIKEG-NYLAVGTSSAEVQLWDVQ----------QQKRL 261 +G I +++ ++ ++ + + +A T S++V ++D + Sbjct: 114 TGKIECEIKI-NHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPD 172 Query: 262 RNMTSHSARVGSLSWNSYI---LSSGSRSGHIHHHDVRVAEHHV------ATLSGHSQEV 312 + H LSWNS + L S S + D+ A +GHS V Sbjct: 173 LRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVV 232 Query: 313 CGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVL 371 + W S +D + +W + P H V +++ P+ +L Sbjct: 233 EDVAWHLLHESLFGSVADDQKLMIWDTRSNT-TSKPSHLVDAHTAEVNCLSFNPYSEFIL 291 Query: 372 ATGGGTSDRHIRIWNVCSGA-CLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWK 429 AT G++D+ + +W++ + L ++H ++ + WSPH + +++ G +L +W Sbjct: 292 AT--GSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSG-TDRRLNVWD 348 Query: 430 YPTMAKVAELK--------------GHTSRVLSLTMSPDGAT-VASAAADETLRLWRCFE 474 + + + GHT+++ + +P+ + S + D +++W+ E Sbjct: 349 LSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAE 408 >6EMK-B nrPDB Length = 303 Score = 165 bits (417), Expect = 5e-41, Method: Composition-based stats. Identities = 42/244 (17%), Positives = 88/244 (36%), Gaps = 18/244 (7%) Query: 240 YLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRV 297 L ++ W+ R + ++V L + +L++ + +D+R Sbjct: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDIRT 62 Query: 298 AE-HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG 356 + VA+ GH V + + D R + + D + VW + +H Sbjct: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRS-----PSIPRNYKHNA 117 Query: 357 AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELIS 416 V V P Q +++ D +IRIW++ C + S + Sbjct: 118 PVNEVVIHPNQGELISCD---RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 Query: 417 GHGFAQNQLVIWKYPT------MAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 + +W+ P + V + + H++ + + +S D +A+ +AD T R+W Sbjct: 175 AAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW 234 Query: 471 RCFE 474 + Sbjct: 235 SIDD 238 Score = 132 bits (331), Expect = 5e-31, Method: Composition-based stats. Identities = 50/302 (16%), Positives = 106/302 (35%), Gaps = 12/302 (3%) Query: 157 TPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDI 216 T R+ +L + + L + +LA A +V L+ + + Sbjct: 6 VSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNP 65 Query: 217 LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW 276 + E ++SV++ ++ ++ + +++WDV+ RN H+A V + Sbjct: 66 NPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVI 124 Query: 277 NSYI--LSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVN 334 + L S R G+I D+ + + L A DG LA+ Sbjct: 125 HPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCY 184 Query: 335 VWPS--APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG-A 391 VW P+ F H + + ++ ++D R+W++ Sbjct: 185 VWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHL---ATCSADHTARVWSIDDDFK 241 Query: 392 CLSAVDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLT 450 + +D H V +S L++ + + + +W T V + GH + + Sbjct: 242 LETTLDGHQRWVWDCAFSADSAYLVTAS--SDHYVRLWDLSTREIVRQYGGHHKGAVCVA 299 Query: 451 MS 452 ++ Sbjct: 300 LN 301 Score = 85.2 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 29/172 (16%), Positives = 68/172 (39%), Gaps = 14/172 (8%) Query: 324 LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIR 383 L S G D+ + W + G V +T V + +LAT G +++R Sbjct: 5 LVSAGYDHTIRFWEALTG----VCSRTIQHSDSQVNRLEIT-NDKKLLATAGH---QNVR 56 Query: 384 IWNVCSGAC--LSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK 440 ++++ + +++ + H V S+ + + +++ + +W + + K Sbjct: 57 LYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSS--EDGTIKVWDVRSPSIPRNYK 114 Query: 441 GHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSS 492 H + V + + P+ + S D +R+W E + E ++ +S Sbjct: 115 -HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSL 165 Score = 72.5 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 25/125 (20%), Positives = 49/125 (39%), Gaps = 2/125 (1%) Query: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKY 430 + D IR W +G C + + L + K+L++ G +L + Sbjct: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 Query: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAK 490 VA +GH V S++ D + +++ D T+++W P+ R + + Sbjct: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVR--SPSIPRNYKHNAPVN 120 Query: 491 SSLIH 495 +IH Sbjct: 121 EVVIH 125 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 15/83 (18%), Positives = 35/83 (42%), Gaps = 1/83 (1%) Query: 196 NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV 255 ++ + D++ +WS D ++ ++ A+ + YL +S V+LWD+ Sbjct: 221 HLATCSADHTARVWSID-DDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 Query: 256 QQQKRLRNMTSHSARVGSLSWNS 278 ++ +R H ++ N Sbjct: 280 STREIVRQYGGHHKGAVCVALND 302 >3JB9-g nrPDB Length = 558 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 59/378 (15%), Positives = 125/378 (33%), Gaps = 29/378 (7%) Query: 109 KKEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYI 168 + E K L + +K + K + YQNR + S + Sbjct: 195 QNELLK-EQLATPEVETHRSKEETILHK--DRLFDYQNRSYMHVPNDVGINLSEEPGEQT 251 Query: 169 PSLPDR--ILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPG 226 +P + + L S +L+ ++DN + +W L L + Sbjct: 252 CYIPKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSL-LRTFQGHA 310 Query: 227 EYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN-----SYIL 281 I +++ ++G + ++LWD + K L S + + Sbjct: 311 RPIRDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNS-DRLTNCVKFQVDPDKPNEF 369 Query: 282 SSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPG 341 +G+ I D+R + V H + + + +G+ + +D+ + W Sbjct: 370 LAGTADKRILQFDIRSPDI-VQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGT- 427 Query: 342 EGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG---ACLSAVDA 398 + H VA P ++ + D I +++ Sbjct: 428 PVPIKFVADIAMHSMP--RVALRPNGKSI---ACQSLDNCIYVYSAYEKYRQNKKKVFKG 482 Query: 399 HS---QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDG 455 +S + +SP + + S G + W + T +A+L H+ V S+ P Sbjct: 483 YSCSGYSLEVGFSPDGRFVFS--GDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQE 540 Query: 456 -ATVASAA-ADETLRLWR 471 + VA+++ D +++ W Sbjct: 541 TSKVATSSIVDGSIKYWD 558 Score = 137 bits (345), Expect = 1e-32, Method: Composition-based stats. Identities = 45/223 (20%), Positives = 92/223 (41%), Gaps = 16/223 (7%) Query: 259 KRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGL 315 K + H+ + L + + ++L SGS I +V + T GH++ + L Sbjct: 257 KHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDL 316 Query: 316 RWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGG 375 ++ DGR S D + +W + G+ L F V + Sbjct: 317 SFSQDGRSFLSTSFDKTIKLWDTELGK----CLNCFNS-DRLTNCVKFQVDPDKPNEFLA 371 Query: 376 GTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA 434 GT+D+ I +++ S + A D H + SI + + K ++ + + W+Y T Sbjct: 372 GTADKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSD--DSSMRFWEYGTPV 429 Query: 435 K---VAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474 VA++ H+ + + + P+G ++A + D + ++ +E Sbjct: 430 PIKFVADIAMHS--MPRVALRPNGKSIACQSLDNCIYVYSAYE 470 Score = 46.3 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 13/67 (19%), Positives = 23/67 (34%), Gaps = 2/67 (2%) Query: 433 MAKVAELKGHTSRVLSLTMSP-DGATVASAAADETLRLWRCF-ELDPARRREREKASAAK 490 + KGHT + L P G + S + D +++W + + R + Sbjct: 256 KKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRD 315 Query: 491 SSLIHQG 497 S G Sbjct: 316 LSFSQDG 322 >5K1B-B nrPDB Length = 677 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 57/233 (24%), Positives = 98/233 (42%), Gaps = 19/233 (8%) Query: 268 SARVGSLSWNSYI--LSSGSRSGHIHHHDVR--VAEHHVATLSGHSQEVCGLRWAPDGRH 323 V +L + + L + R I V + ++A++ H+ V + +G+ Sbjct: 30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKT 89 Query: 324 LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIR 383 L S +D V VW + G + T H+ VKA+A+ + V + G DR I Sbjct: 90 LISASSDTTVKVWNAHKG----FCMSTLRTHKDYVKALAYAKDKELVASAG---LDRQIF 142 Query: 384 IWNVCSGACLSAVDAHSQVCSI------LWSPHYKEL--ISGHGFAQNQLVIWKYPTMAK 435 +W+V + L+A + S+ ++S +L I G + L +W T AK Sbjct: 143 LWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAK 202 Query: 436 VAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASA 488 + +LKGHT V +L ++ DG S ++D T+RLW + Sbjct: 203 LMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGV 255 Score = 140 bits (352), Expect = 2e-33, Method: Composition-based stats. Identities = 49/284 (17%), Positives = 103/284 (36%), Gaps = 23/284 (8%) Query: 166 RYIPSLPDRILDAPEIRNDYYLNLVDWSS--GNVLAVALDNSVYLWSASSGDILQLLQ-M 222 R + I D E N +N + + D+ + +WS + + M Sbjct: 12 RRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASM 71 Query: 223 EQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYI 280 E ++++ + G L +S V++W+ + + + +H V +L++ + + Sbjct: 72 EHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKEL 131 Query: 281 LSSGSRSGHIHHHDVRV--------AEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNL 332 ++S I DV ++LSG+ + L G + SG + + Sbjct: 132 VASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKV 191 Query: 333 VNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGAC 392 + VW L H VKA+ + L+ G+SD IR+W++ C Sbjct: 192 LRVWDPRTCAK----LMKLKGHTDNVKALLLNRDGTQCLS---GSSDGTIRLWSLGQQRC 244 Query: 393 LSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAK 435 ++ H + V ++ + + + S G ++ Sbjct: 245 IATYRVHDEGVWALQVNDAFTHVYS--GGRDRKIYCTDLRNPDI 286 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 51/282 (18%), Positives = 113/282 (40%), Gaps = 27/282 (9%) Query: 229 ISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKR---LRNMTSHSARVGS--LSWNSYILSS 283 ++++ N L + +++W V Q K+ + +M H+ V L N L S Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLIS 92 Query: 284 GSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS----- 338 S + + ++TL H V L +A D +AS G D + +W Sbjct: 93 ASSDTTVKVWNAHKG-FCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTA 151 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 V + + ++ ++ ++A + +++ G++++ +R+W+ + A L + Sbjct: 152 LTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVS---GSTEKVLRVWDPRTCAKLMKLKG 208 Query: 399 HSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGAT 457 H+ V ++L + + +SG + + +W +A + H V +L ++ Sbjct: 209 HTDNVKALLLNRDGTQCLSGS--SDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTH 266 Query: 458 VASAAADET----------LRLWRCFELDPARRREREKASAA 489 V S D +R+ C E P + E ++++ Sbjct: 267 VYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADP 308 Score = 115 bits (287), Expect = 5e-26, Method: Composition-based stats. Identities = 39/198 (19%), Positives = 75/198 (37%), Gaps = 14/198 (7%) Query: 311 EVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370 V L+ P L + G D+++ +W S + + H V + C + Sbjct: 32 GVNALQLDPALNRLFTAGRDSIIRIW-SVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTL 90 Query: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKY 430 ++ +SD +++WN G C+S + H L KEL++ G Q+ +W Sbjct: 91 IS---ASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGL-DRQIFLWDV 146 Query: 431 PTMAKVA---------ELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRR 481 T+ + L G+ + SL M+ G + S + ++ LR+W + Sbjct: 147 NTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKL 206 Query: 482 EREKASAAKSSLIHQGIR 499 + + L G + Sbjct: 207 KGHTDNVKALLLNRDGTQ 224 Score = 86.4 bits (212), Expect = 3e-17, Method: Composition-based stats. Identities = 37/265 (13%), Positives = 88/265 (33%), Gaps = 33/265 (12%) Query: 178 APEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKE 237 ++ Y ++ +++ + + + +W + +L++++ + + ++ ++ Sbjct: 164 LSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRT--CAKLMKLKGHTDNVKALLLNRD 221 Query: 238 GNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYI--LSSGSRSGHIHHHDV 295 G G+S ++LW + QQ+ + H V +L N + SG R I+ D+ Sbjct: 222 GTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDL 281 Query: 296 RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQ 355 R + V V + D +W + + Sbjct: 282 RNPDIRVLICEE-KAPVLKMELDR--------SADPPPAIWVATT--------------K 318 Query: 356 GAVKAVAWCPWQ-SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKEL 414 V W N A+G +D I +C+ + + + + + Sbjct: 319 STVN--KWTLKGIHNFRASGDYDNDCTNPITPLCT-QPDQVIKGGASIIQCHILNDKRHI 375 Query: 415 ISGHGFAQNQLVIWKYPTMAKVAEL 439 ++ N + W KV +L Sbjct: 376 LT--KDTNNNVAYWDVLKACKVEDL 398 >4J0W-A nrPDB Length = 343 Score = 157 bits (397), Expect = 1e-38, Method: Composition-based stats. Identities = 65/304 (21%), Positives = 107/304 (35%), Gaps = 36/304 (11%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQME---------QPGEYISSVAWIKEGNYLAVGTSS 247 + + A D S+ WS SG L ++ ++ +A +G YLA G S Sbjct: 29 IFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRS 88 Query: 248 AEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATL 305 + +W+ Q + L T H V L++ ++ L S S + +V +V TL Sbjct: 89 KLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNV-AENSYVETL 147 Query: 306 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 365 GH V L + +GG D V VW P E V F HQG++ + Sbjct: 148 FGHQDAVAALDALSRECCVTAGGRDGTVRVW-KIPEESQLV----FYGHQGSIDCIHLIN 202 Query: 366 WQSNVLATGGGTSDRHIRIWNVCSGACL------SAVDAHSQVCSILWSPHYKEL----I 415 + V G D + +W + L + + W L + Sbjct: 203 EEHMV----SGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDL 258 Query: 416 SGHGFAQNQLVIWKYPTMAKVAELKGH---TSRVLSLTMSPDGATVASA-AADETL-RLW 470 G + + +W+ + +L + SL S G + + + L R W Sbjct: 259 VATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLKFSSSGDFLVAGVGQEHRLGRWW 318 Query: 471 RCFE 474 R E Sbjct: 319 RIKE 322 Score = 140 bits (353), Expect = 1e-33, Method: Composition-based stats. Identities = 46/238 (19%), Positives = 91/238 (38%), Gaps = 22/238 (9%) Query: 261 LRNMTSHSARVGS--LSWNSYILSSGSRSGHIHHHDVRVAEHHVATL----------SGH 308 +R + H + ++ + + S ++ I V GH Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 66 Query: 309 SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS 368 S V + + DG++LASG L+ +W + + + TFT H+ AV +A+ Sbjct: 67 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLY----TFTGHRDAVSGLAFRRGTH 122 Query: 369 NVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIW 428 + +T + DR +++WNV + + + H + L +E G + +W Sbjct: 123 QLYST---SHDRSVKVWNVAENSYVETLFGHQDAVAAL-DALSRECCVTAGGRDGTVRVW 178 Query: 429 KYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKA 486 K P +++ GH + + + + V S A D ++ LW + P + Sbjct: 179 KIPEESQL-VFYGHQGSIDCIHLINEEHMV-SGADDGSVALWGLSKKRPLALQREAHG 234 Score = 85.2 bits (209), Expect = 6e-17, Method: Composition-based stats. Identities = 29/157 (18%), Positives = 52/157 (33%), Gaps = 17/157 (10%) Query: 348 LQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVD---------- 397 ++ HQ ++ + P S + + D I W+V SG L + Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIFS---AAKDCSIIKWSVESGRKLHVIPRAKKGAEGKP 63 Query: 398 -AHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDG 455 HS V + S K L G ++IW+ + + GH V L Sbjct: 64 PGHSSHVLCMAISSDGKYL--ASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGT 121 Query: 456 ATVASAAADETLRLWRCFELDPARRREREKASAAKSS 492 + S + D ++++W E + + A Sbjct: 122 HQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALD 158 Score = 79.8 bits (195), Expect = 3e-15, Method: Composition-based stats. Identities = 22/210 (10%), Positives = 68/210 (32%), Gaps = 19/210 (9%) Query: 179 PEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEG 238 R+ + + + + D SV +W+ + ++ + + ++++ + Sbjct: 106 TGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVE--TLFGHQDAVAALDALSRE 163 Query: 239 NYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS-WNSYILSSGSRSGHIHHHDVRV 297 + G V++W + ++ +L H + + N + SG+ G + + Sbjct: 164 CCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSK 222 Query: 298 AEHHVATLSGH----------SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPG--EGGW 345 H + + + +A+G + + V +W G + Sbjct: 223 KRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDL 282 Query: 346 VPLQTFTQHQGAVKAVAWCPWQSNVLATGG 375 + + ++ + ++A G Sbjct: 283 LCDIPLVG---FINSLKFSSSGDFLVAGVG 309 Score = 54.4 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 16/113 (14%), Positives = 39/113 (34%), Gaps = 14/113 (12%) Query: 393 LSAVDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVA-----------ELK 440 + + H + ++ +P + S ++ W + K+ + Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIFSAA--KDCSIIKWSVESGRKLHVIPRAKKGAEGKPP 64 Query: 441 GHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSL 493 GH+S VL + +S DG +AS + + +W + + + + Sbjct: 65 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAF 117 >5WJC-A nrPDB Length = 430 Score = 156 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 48/253 (18%), Positives = 96/253 (37%), Gaps = 24/253 (9%) Query: 267 HSARVGSLSW---NSYILSSGSRSGHIHHHDVR-------VAEHHVATLSGHSQEVCGLR 316 H V + I+++ G+ + D A L GH+ E GL Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 317 WAPDGR-HLASGGNDNLVNVWPS------APGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 369 W P+ +LA+G D ++ +W + P+ + +H V V + P Sbjct: 190 WNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEA 249 Query: 370 VLATGGGTSDRHIRIWNVC---SGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLV 426 +LA+ + D ++I + + AHS+ + + + + + A + Sbjct: 250 LLASV--SDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVA 307 Query: 427 IWKYPTM-AKVAELKGHTSRVLSLTMSP-DGATVASAAADETLRLWRCFELDPARRRERE 484 +W ++ L+GH V L SP D +AS++ D + +W ++ + E Sbjct: 308 LWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDA 367 Query: 485 KASAAKSSLIHQG 497 + + + +H G Sbjct: 368 EDGSPELLFMHGG 380 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 48/226 (21%), Positives = 92/226 (40%), Gaps = 31/226 (13%) Query: 190 VDWSS---GNVLAVALDNSVYLWSASSGDILQ--------LLQMEQPGEYISSVAWIKEG 238 + W+ GN+ A D + LW + + + + + ++ V + + Sbjct: 188 LCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQH 247 Query: 239 N-YLAVGTSSAEVQLWDVQ---QQKRLRNMTSHSARVGSLS---WNSYILSSGSRSGHIH 291 LA + +Q+ D + +++ + + +HS + +++ +N Y+L++ S + Sbjct: 248 EALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVA 307 Query: 292 HHDVRVAEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAP---------- 340 D+R + TL GH EV GL W+P D LAS D V +W Sbjct: 308 LWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDA 367 Query: 341 GEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWN 386 +G L H + +WCP + V+ G D ++IW+ Sbjct: 368 EDGSPELLFMHGGHTNRISEFSWCPNERWVV--GSLADDNILQIWS 411 Score = 144 bits (364), Expect = 7e-35, Method: Composition-based stats. Identities = 74/427 (17%), Positives = 139/427 (32%), Gaps = 85/427 (19%) Query: 105 QTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEGY-----------QNRLKVLYS 153 P + A D+++ QN P Y ++ L Sbjct: 8 DAPLENNELNAE------IDLQKTIQEEYKLWKQNVPFLYDLVITHALEWPSLTIQWLPD 61 Query: 154 QKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASS 213 +K PG+ R I D N + +S + D + + + Sbjct: 62 KKTIPGTDYSIQRLILGTHTSGNDQ---------NYLQIASVQLPNFDEDTTEF-----T 107 Query: 214 GDILQLLQMEQPGEYISSVAWIKEGN------------YLAVGTSSAEVQLWDVQ----- 256 ++ Q S +G+ +A ++D Sbjct: 108 PSTIRRAQATGSYTIEISQKIPHDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDAL 167 Query: 257 ---QQKRLRNMTSHSARVGSLSWNSYI---LSSGSRSGHIHHHDVRVAE---------HH 301 + + H+A L WN + L++G+ I DV+ Sbjct: 168 TTGEALPQAVLKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISP 227 Query: 302 VATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 360 +A H+ V +++ P LAS +D + + + P + H A+ A Sbjct: 228 IAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAP-KVIQAHSKAINA 286 Query: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAVDAH-SQVCSILWSPHYKELISGH 418 VA P+ +LAT ++D+ + +W++ + L ++ H +V + WSPH E I Sbjct: 287 VAINPFNDYLLATA--SADKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSPH-DEPILAS 343 Query: 419 GFAQNQLVIWKYPTMAKVAELK--------------GHTSRVLSLTMSPDGATVA-SAAA 463 ++ IW + + + GHT+R+ + P+ V S A Sbjct: 344 SSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLAD 403 Query: 464 DETLRLW 470 D L++W Sbjct: 404 DNILQIW 410 >2PM9-A nrPDB Length = 416 Score = 156 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 59/317 (18%), Positives = 123/317 (38%), Gaps = 28/317 (8%) Query: 201 ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKR 260 + D+S+ LWS + D + + Q + + W +A + ++L+ + Sbjct: 42 STDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHNNKIIAGALDNGSLELYSTNEANN 101 Query: 261 ----LRNMTSHSARVGSLSWNSY---ILSSGSRSGHIHHHDVR----VAEHHVATLSGHS 309 + ++HS+ V ++ +N+ +L+SG +G I D+ ++ G S Sbjct: 102 AINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQS 161 Query: 310 ----QEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA---- 360 EV L W H AS G+ N ++W V ++T +K Sbjct: 162 MSSVDEVISLAWNQSLAHVFASAGSSNFASIWDL--KAKKEVIHLSYTSPNSGIKQQLSV 219 Query: 361 VAWCPWQSNVLATGGGTS-DRHIRIWNVCSGAC-LSAVDAHSQ--VCSILWSPHYKELIS 416 V W P S +AT G+ D I IW++ + L ++ Q + S+ W + L+ Sbjct: 220 VEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLL 279 Query: 417 GHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAA-DETLRLWRCFEL 475 G N +++W + ++++ + +P+ + + A+ D + + L Sbjct: 280 SSG-RDNTVLLWNPESAEQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQNL 338 Query: 476 DPARRREREKASAAKSS 492 + + +S Sbjct: 339 TNTLDEQETETKQQESE 355 Score = 35.9 bits (81), Expect = 0.045, Method: Composition-based stats. Identities = 15/70 (21%), Positives = 29/70 (41%), Gaps = 6/70 (8%) Query: 187 LNLVDWS---SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEG-NYLA 242 + +DW +L+ DN+V LW+ S QL Q G + + E + A Sbjct: 265 ILSLDWCHQDEHLLLSSGRDNTVLLWNPESA--EQLSQFPARGNWCFKTKFAPEAPDLFA 322 Query: 243 VGTSSAEVQL 252 + ++++ Sbjct: 323 CASFDNKIEV 332 >4L9O-A nrPDB Length = 349 Score = 155 bits (392), Expect = 4e-38, Method: Composition-based stats. Identities = 56/261 (21%), Positives = 96/261 (36%), Gaps = 22/261 (8%) Query: 189 LVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKE--GNYLAVGTS 246 ++D+ + + D ++ ++ + + + + VAW G LA + Sbjct: 76 VLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSY 135 Query: 247 SAEVQLW--DVQQQKRLRNMTSHSARVGSLSWNSY----ILSSGSRSGHIHHHDVRVAE- 299 +V +W D ++ + H A V S+SW + +L S G I + + Sbjct: 136 DGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGA 195 Query: 300 HHVATLSGHSQEVCGLRWAP-----DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQH 354 + GH+ V WAP + R SGG DNLV +W ++ + F H Sbjct: 196 LEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGH 255 Query: 355 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIW------NVCSGACLSAVDAHSQVCSILWS 408 V+ VAW P + + + DR + IW N L+ WS Sbjct: 256 SDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWS 315 Query: 409 PHYKELISGHGFAQNQLVIWK 429 L G N++ +WK Sbjct: 316 LSGNVLAISGG--DNKVTLWK 334 Score = 88.7 bits (218), Expect = 6e-18, Method: Composition-based stats. Identities = 35/176 (19%), Positives = 69/176 (39%), Gaps = 15/176 (8%) Query: 307 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAW-CP 365 H + GR LA+ +D + ++ ++T H+G V VAW P Sbjct: 67 AHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRL--VETLIGHEGPVWQVAWAHP 124 Query: 366 WQSNVLATGGGTSDRHIRIWNVCSG--ACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQ 422 +LA+ + D + IW +G ++ H V S+ W+PH + + Sbjct: 125 KFGVILASC--SYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSD 182 Query: 423 NQLVIWKYPTMAKVA--ELKGHTSRVLSLTMSP-----DGATVASAAADETLRLWR 471 ++ I ++ + ++GH V + + +P + S D +++WR Sbjct: 183 GKISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWR 238 Score = 33.2 bits (74), Expect = 0.28, Method: Composition-based stats. Identities = 8/57 (14%), Positives = 24/57 (42%), Gaps = 9/57 (15%) Query: 441 GHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 H + + G +A+ ++D+T++++ + E ++ + H+G Sbjct: 67 AHDDLIHDAVLDYYGRRLATCSSDKTIKIFEI---------DGENQRLVETLIGHEG 114 >5XYI-g nrPDB Length = 335 Score = 154 bits (390), Expect = 6e-38, Method: Composition-based stats. Identities = 51/304 (16%), Positives = 109/304 (35%), Gaps = 33/304 (10%) Query: 190 VDWSSGNVLAVALDNSVYLWSASSGD---ILQLLQMEQPGEYISSVAWIKEGNYLAVGTS 246 +D +++ + D S +W + ++ ++S V+ ++ ++L + Sbjct: 41 IDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLSRDASHLLTSSW 100 Query: 247 SAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVAT 304 + ++LWD+ + + H V ++++ + S R + ++ Sbjct: 101 DSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRDNQVKIWNILGENKAELQ 160 Query: 305 LSGHSQEVCGLRWAPDGR-----HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVK 359 S V + AP +A G D V +W E ++ F H G Sbjct: 161 ---CSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSI---EKEAKLIKEFKAHDGRCT 214 Query: 360 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHG 419 +V + P V+ G SDR + +W +GA + A S V ++ P + + Sbjct: 215 SVDFTPDGKWVI---TGGSDRKVVMWLTENGAKTISFTAPSPVHAVAACPTQAWICAATY 271 Query: 420 FAQNQLVIWKYPTMAKVAELK-----------GHTSRVLSLTMSPDGATVASAAADETLR 468 + +W ++ ++ G T L + DG+ + S D ++R Sbjct: 272 EG---IAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIR 328 Query: 469 LWRC 472 W Sbjct: 329 AWEV 332 Score = 111 bits (276), Expect = 9e-25, Method: Composition-based stats. Identities = 44/215 (20%), Positives = 72/215 (33%), Gaps = 51/215 (23%) Query: 303 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQT------------ 350 AT GH+ + + + +L S D VW + W T Sbjct: 27 ATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDV 86 Query: 351 -------------------------------FTQHQGAVKAVAWCPWQSNVLATGGGTSD 379 F H+ V V + P +++ G D Sbjct: 87 SLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVG---RD 143 Query: 380 RHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKE---LISGHGFAQNQLVIWKYPTMAK- 435 ++IWN+ G + + S V S+ +P E L+ G ++ IW AK Sbjct: 144 NQVKIWNIL-GENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEAKL 202 Query: 436 VAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 + E K H R S+ +PDG V + +D + +W Sbjct: 203 IKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMW 237 Score = 68.7 bits (166), Expect = 6e-12, Method: Composition-based stats. Identities = 36/219 (16%), Positives = 66/219 (30%), Gaps = 62/219 (28%) Query: 180 EIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGN 239 + D + +++V DN V +W+ + +L Q +++SVA + Sbjct: 120 GHKKDVLGVTFSPCNRRIISVGRDNQVKIWNILGENKAEL----QCSSWVTSVACAPMAD 175 Query: 240 -----YLAVGTSSAEVQLWDVQ-QQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIH 291 +AVG +V +W ++ + K ++ +H R S+ + + + +G + Sbjct: 176 ETSPLVIAVGCWDGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVV 235 Query: 292 HHDVRVAEH----------------------HVATLSG--------------------HS 309 AT G H Sbjct: 236 MWLTENGAKTISFTAPSPVHAVAACPTQAWICAATYEGIAVWDIGAKQQIDLVQPNFKHE 295 Query: 310 Q--------EVCGLRWAPDGRHLASGGNDNLVNVWPSAP 340 + L WA DG L SG ND + W Sbjct: 296 GKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWEVKS 334 Score = 55.6 bits (132), Expect = 6e-08, Method: Composition-based stats. Identities = 19/91 (20%), Positives = 34/91 (37%), Gaps = 8/91 (8%) Query: 395 AVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPT-----MAKVAELKGHTSRVLS 448 H+ + SI + L+S ++WK L GH V Sbjct: 28 TFVGHNAAIESIEIDNEHNYLVSAS--RDKSALVWKLNRTQEQWATPFTRLIGHNHFVSD 85 Query: 449 LTMSPDGATVASAAADETLRLWRCFELDPAR 479 +++S D + + +++ D TLRLW + Sbjct: 86 VSLSRDASHLLTSSWDSTLRLWDLSTRTTKK 116 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 23/159 (14%), Positives = 45/159 (28%), Gaps = 54/159 (33%) Query: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 252 S + D VY+WS + + + + +SV + +G ++ G S +V + Sbjct: 178 SPLVIAVGCWDGKVYIWSIE-KEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVM 236 Query: 253 WDVQQQKRLRNMT----------------------------------------------- 265 W + + + T Sbjct: 237 WLTENGAKTISFTAPSPVHAVAACPTQAWICAATYEGIAVWDIGAKQQIDLVQPNFKHEG 296 Query: 266 ----SHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVA 298 + L+W + +L SG G I +V+ A Sbjct: 297 KRNAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWEVKSA 335 >6CHG-A nrPDB Length = 312 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 56/291 (19%), Positives = 117/291 (40%), Gaps = 32/291 (10%) Query: 224 QPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYIL 281 G+ +S +G +A+ + ++ ++++ K ++ T+H + L W +S + Sbjct: 11 ASGKISTSCQISPDGELIAIC-QNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSKCI 69 Query: 282 SSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPG 341 +SGS + + + L GH+ V + + G L S D + W G Sbjct: 70 ASGSEDFTVEI--THIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSG 127 Query: 342 EGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV----- 396 L+T + H AV ++ + S++L++ G+ D IRI++ SG CL + Sbjct: 128 TA----LKTMSAHSDAVVSIDIPKFDSSILSS--GSYDGLIRIFDTESGHCLKTLTYDKD 181 Query: 397 ----DAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAE-LKGHTSRVLSLTM 451 D + ++ +S + K L+ N + +W+Y V L H L Sbjct: 182 WIAEDGVVPISTVKFSRNGKFLLVKS--LDNVVKLWEYTRGTVVRTFLWPHQETKAKLKY 239 Query: 452 S-------PDGA--TVASAAADETLRLWRCFELDPARRREREKASAAKSSL 493 + P G V S ++ +W + + ++ + + ++ S+ Sbjct: 240 NCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEKHRNSPLISI 290 Score = 133 bits (335), Expect = 2e-31, Method: Composition-based stats. Identities = 53/251 (21%), Positives = 103/251 (41%), Gaps = 25/251 (9%) Query: 187 LNLVDWS--SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVG 244 +N + WS S + + + D +V + G I +L+ + S+ + +GN L Sbjct: 57 INCLCWSPDSKCIASGSEDFTVEITHIIYGRIRRLM---GHTAPVISICYNNKGNILCSS 113 Query: 245 TSSAEVQLWDVQQQKRLRNMTSHSARVGSLS---WNSYILSSGSRSGHIHHHDVRVAEHH 301 + ++ W V L+ M++HS V S+ ++S ILSSGS G I D H Sbjct: 114 SMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESG-HC 172 Query: 302 VATLSGHSQE--------VCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ 353 + TL+ + ++++ +G+ L DN+V +W G L + Sbjct: 173 LKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQE 232 Query: 354 HQGAVK-----AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA-HSQVCSILW 407 + +K + + + ++ +G + + +WNV S + +D H I Sbjct: 233 TKAKLKYNCGLELIYPQGKDPLVISGNDS--GSMCVWNVYSKNLVQKIDEKHRNSPLISI 290 Query: 408 SPHYKELISGH 418 S Y ++ + Sbjct: 291 SASYDKVATLS 301 Score = 117 bits (293), Expect = 1e-26, Method: Composition-based stats. Identities = 61/303 (20%), Positives = 120/303 (39%), Gaps = 37/303 (12%) Query: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 252 G ++A+ + + ++ SS +++L E I+ + W + +A G+ V++ Sbjct: 23 PDGELIAICQNTDMLVYEISSSKMMKL--TTTHKECINCLCWSPDSKCIASGSEDFTVEI 80 Query: 253 WDVQQQKRLRNMTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQ 310 + R+R + H+A V S+ +N+ IL S S I V + T+S HS Sbjct: 81 THIIYG-RIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGT-ALKTMSAHSD 138 Query: 311 EVCGLRWAP--DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGA--------VKA 360 V + P D L+SG D L+ ++ + G L+T T + + Sbjct: 139 AVVSIDI-PKFDSSILSSGSYDGLIRIFDTESGH----CLKTLTYDKDWIAEDGVVPIST 193 Query: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVD-AHSQVCSI--------LWSPHY 411 V + +L + D +++W G + H + + L P Sbjct: 194 VKFSRNGKFLL---VKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLELIYPQG 250 Query: 412 KELISGHGFAQNQLVIWKYPTMAKVAEL--KGHTSRVLSLTMSPDGATVASAAADETLRL 469 K+ + G + +W + V ++ K S ++S++ S D VA+ + + L Sbjct: 251 KDPLVISGNDSGSMCVWNVYSKNLVQKIDEKHRNSPLISISASYD--KVATLSLNGECNL 308 Query: 470 WRC 472 +R Sbjct: 309 FRV 311 Score = 74.8 bits (182), Expect = 9e-14, Method: Composition-based stats. Identities = 28/207 (13%), Positives = 63/207 (30%), Gaps = 22/207 (10%) Query: 156 ATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGD 215 GS T + RI + + + ++D S+ W SG Sbjct: 69 IASGSEDFTVEITHIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGT 128 Query: 216 ILQLLQMEQPGEYISSVAWIK-EGNYLAVGTSSAEVQLWDVQQQKRLRNMT--------S 266 L+ + + + S+ K + + L+ G+ ++++D + L+ +T Sbjct: 129 ALKTMS--AHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAED 186 Query: 267 HSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP----- 319 + ++ + N L S + + L H + L++ Sbjct: 187 GVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLELI 246 Query: 320 ----DGRHLASGGNDNLVNVWPSAPGE 342 + SG + + VW Sbjct: 247 YPQGKDPLVISGNDSGSMCVWNVYSKN 273 Score = 74.4 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 30/185 (16%), Positives = 66/185 (35%), Gaps = 13/185 (7%) Query: 313 CGLRWAPDGRHLASG-GNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVL 371 + +PDG +A D LV ++ T H+ + + W P Sbjct: 17 TSCQISPDGELIAICQNTDMLV------YEISSSKMMKLTTTHKECINCLCWSPDSK--- 67 Query: 372 ATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYP 431 G+ D + I ++ G + + V SI ++ L S + W Sbjct: 68 CIASGSEDFTVEITHIIYGRIRRLMGHTAPVISICYNNKGNILCSSS--MDESIKEWHVL 125 Query: 432 TMAKVAELKGHTSRVLSLTMSP-DGATVASAAADETLRLWRCFELDPARRREREKASAAK 490 + + + H+ V+S+ + D + ++S + D +R++ + +K A+ Sbjct: 126 SGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAE 185 Query: 491 SSLIH 495 ++ Sbjct: 186 DGVVP 190 Score = 59.8 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 21/140 (15%), Positives = 48/140 (34%), Gaps = 13/140 (9%) Query: 365 PWQSNVLATGGGTSDRHI---------RIWNVCSGACLSAVDAHSQ-VCSILWSPHYKEL 414 P + + + D + ++ + S + H + + + WSP K Sbjct: 10 PASGKISTSCQISPDGELIAICQNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSK-- 67 Query: 415 ISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474 G + I ++ L GHT+ V+S+ + G + S++ DE+++ W Sbjct: 68 CIASGSEDFTVEITHIIYG-RIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLS 126 Query: 475 LDPARRREREKASAAKSSLI 494 + + + Sbjct: 127 GTALKTMSAHSDAVVSIDIP 146 >3JRO-A nrPDB Length = 753 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 54/270 (20%), Positives = 95/270 (35%), Gaps = 32/270 (11%) Query: 189 LVDWSSGNVLAVALDNSVYLWSASSGDILQLLQ-MEQPGEYISSVAWIKE--GNYLAVGT 245 ++D+ + + D ++ ++ G+ +L+ + + V W G LA + Sbjct: 16 VLDYYGKRLATCSSDKTIKIFEVE-GETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCS 74 Query: 246 SSAEVQLWDVQQQ--KRLRNMTSHSARVGSLSWNSY----ILSSGSRSGHIHHHDVR-VA 298 +V +W + ++ HSA V S+ W + +L S G + + + Sbjct: 75 YDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENG 134 Query: 299 EHHVATLSGHSQEVCGLRWAP-------------DGRHLASGGNDNLVNVWPSAPGEGGW 345 + H+ V WAP + R +GG DNLV +W + Sbjct: 135 TTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTY 194 Query: 346 VPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW--NVCSGACLSAVDAHSQVC 403 V T H V+ VAW P + DR IW + G + + Sbjct: 195 VLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFP 254 Query: 404 SIL----WSPHYKELISGHGFAQNQLVIWK 429 +L WS L G N++ +WK Sbjct: 255 DVLWRASWSLSGNVLALSGG--DNKVTLWK 282 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 59/248 (23%), Positives = 98/248 (39%), Gaps = 36/248 (14%) Query: 274 LSWNSYILSSGSRSGHIHHHDVRVAEHHVA-TLSGHSQEVCGLRW-APD-GRHLASGGND 330 L + L++ S I +V H + TL+GH V + W P G LAS D Sbjct: 17 LDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYD 76 Query: 331 NLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG 390 V +W G W + H +V +V W P + L +SD + + V Sbjct: 77 GKVLIWKEENG--RWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA-SSDGKVSV--VEFK 131 Query: 391 ACLSA----VDAHS-QVCSILWSP-------------HYKELISGHGFAQNQLVIWKYPT 432 + +DAH+ V S W+P ++ ++ G A N + IWKY + Sbjct: 132 ENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVT--GGADNLVKIWKYNS 189 Query: 433 MAKV----AELKGHTSRVLSLTMSPDG---ATVASAAADETLRLW-RCFELDPARRRERE 484 A+ + L+GH+ V + SP + +AS + D T +W + E P ++ + Sbjct: 190 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLK 249 Query: 485 KASAAKSS 492 + Sbjct: 250 EEKFPDVL 257 Score = 123 bits (309), Expect = 2e-28, Method: Composition-based stats. Identities = 54/278 (19%), Positives = 88/278 (31%), Gaps = 32/278 (11%) Query: 224 QPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV--QQQKRLRNMTSHSARVGSLSW----N 277 E I G LA +S +++++V + K + +T H V + W Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 278 SYILSSGSRSGHIHHHDVRVAEHHVATLSG-HSQEVCGLRWAPD--GRHLASGGNDNLVN 334 IL+S S G + + HS V ++WAP G L +D V+ Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 335 VWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP----------WQSNVLATGGGTSDRHIRI 384 V E G H V + +W P G +D ++I Sbjct: 127 V--VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 Query: 385 W----NVCSGACLSAVDAHSQ-VCSILWSPHYKE-LISGHGFAQNQLVIW--KYPTMAKV 436 W + + S ++ HS V + WSP +IW Sbjct: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 244 Query: 437 AELKGHT---SRVLSLTMSPDGATVASAAADETLRLWR 471 L + + S G +A + D + LW+ Sbjct: 245 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 Score = 32.1 bits (71), Expect = 0.57, Method: Composition-based stats. Identities = 6/38 (15%), Positives = 17/38 (44%) Query: 435 KVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 V H + + G +A+ ++D+T++++ Sbjct: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEV 38 >4XYI-A nrPDB Length = 430 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 42/222 (18%), Positives = 81/222 (36%), Gaps = 28/222 (12%) Query: 194 SGNVLAVALDNSVYLWSAS--------SGDILQLLQMEQPGEYISSVAWIKEGN-YLAVG 244 G + D S+ +W S D+ + + ++ + + + L Sbjct: 195 EGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTSV 254 Query: 245 TSSAEVQLWDVQ---QQKRLRNMTSHSARVGSLSWNS---YILSSGSRSGHIHHHDVRVA 298 + +Q+ D + + + +H V +++N Y+L++ S + D+R Sbjct: 255 SDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRL 314 Query: 299 EHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPS----------APGEGGWVP 347 + TL GH EV ++W+P D L + D V VW +G Sbjct: 315 NQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPEL 374 Query: 348 LQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS 389 + H V ++W P VLA+ D ++IW+ Sbjct: 375 MFMHGGHTNRVSDLSWNPNNKWVLASLA--DDNILQIWSPSK 414 Score = 136 bits (341), Expect = 3e-32, Method: Composition-based stats. Identities = 48/255 (18%), Positives = 99/255 (38%), Gaps = 28/255 (10%) Query: 267 HSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVATLSGH-------SQEVCGLR 316 H V + N I+++ +G+ + D+ + +GH + E GL Sbjct: 130 HEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLG 189 Query: 317 WA--PDGRHLASGGNDNLVNVWPSAPGEGGWV------PLQTFTQHQGAVKAVAWCPWQS 368 W +G LA+G D + VW P+ + +H V + + Sbjct: 190 WNFIQEGT-LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHE 248 Query: 369 NVLATGGGTSDRHIRIWNVC---SGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQ 424 +L + + D ++I + S + V AH Q V + ++P L+ A + Sbjct: 249 ALLTSV--SDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLL-ATASADHT 305 Query: 425 LVIWKYPTM-AKVAELKGHTSRVLSLTMSP-DGATVASAAADETLRLWRCFELDPARRRE 482 + +W + ++ L+GH V ++ SP D + +++ D + +W ++ + E Sbjct: 306 VALWDLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVE 365 Query: 483 REKASAAKSSLIHQG 497 + A + +H G Sbjct: 366 DSEDGAPELMFMHGG 380 Score = 126 bits (317), Expect = 2e-29, Method: Composition-based stats. Identities = 52/290 (17%), Positives = 110/290 (37%), Gaps = 43/290 (14%) Query: 225 PGEYISSVAWIKEG-NYLAVGTSSAEVQLWDVQ--------QQKRLRNMTSHSARVGSLS 275 ++ ++ + + +A + ++D+ Q + H++ L Sbjct: 130 HEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLG 189 Query: 276 WNSYI---LSSGSRSGHIHHHDVRVAEHH---------VATLSGHSQEVCGLRWA-PDGR 322 WN L++G+ I D++ V+ H+ V L++ Sbjct: 190 WNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEA 249 Query: 323 HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHI 382 L S +D + + + Q H+ V VA+ P+ +LAT ++D + Sbjct: 250 LLTSVSDDCTLQIHDTR-LPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATA--SADHTV 306 Query: 383 RIWNVCS-GACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK 440 +W++ L ++ H +V ++ WSPH E I ++ +W + + ++ Sbjct: 307 ALWDLRRLNQRLHTLEGHEDEVYNVQWSPH-DEPILVTSSTDRRVCVWDLSKIGEEQTVE 365 Query: 441 --------------GHTSRVLSLTMSPDGAT-VASAAADETLRLWRCFEL 475 GHT+RV L+ +P+ +AS A D L++W ++ Sbjct: 366 DSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSKV 415 >3JRP-A nrPDB Length = 379 Score = 141 bits (356), Expect = 5e-34, Method: Composition-based stats. Identities = 54/270 (20%), Positives = 95/270 (35%), Gaps = 32/270 (11%) Query: 189 LVDWSSGNVLAVALDNSVYLWSASSGDILQLLQ-MEQPGEYISSVAWIKE--GNYLAVGT 245 ++D+ + + D ++ ++ G+ +L+ + + V W G LA + Sbjct: 18 VLDYYGKRLATCSSDKTIKIFEVE-GETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCS 76 Query: 246 SSAEVQLWDVQQQ--KRLRNMTSHSARVGSLSWNSY----ILSSGSRSGHIHHHDVR-VA 298 +V +W + ++ HSA V S+ W + +L S G + + + Sbjct: 77 YDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENG 136 Query: 299 EHHVATLSGHSQEVCGLRWAP-------------DGRHLASGGNDNLVNVWPSAPGEGGW 345 + H+ V WAP + R +GG DNLV +W + Sbjct: 137 TTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTY 196 Query: 346 VPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW--NVCSGACLSAVDAHSQVC 403 V T H V+ VAW P + DR IW + G + + Sbjct: 197 VLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFP 256 Query: 404 SIL----WSPHYKELISGHGFAQNQLVIWK 429 +L WS L G N++ +WK Sbjct: 257 DVLWRASWSLSGNVLALSGG--DNKVTLWK 284 Score = 117 bits (292), Expect = 2e-26, Method: Composition-based stats. Identities = 58/241 (24%), Positives = 95/241 (39%), Gaps = 33/241 (13%) Query: 258 QKRLRNMTSHSARVGS--LSWNSYILSSGSRSGHIHHHDVRVAEHHVA-TLSGHSQEVCG 314 + +H+ + L + L++ S I +V H + TL+GH V Sbjct: 1 GSMVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWR 60 Query: 315 LRW-APD-GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLA 372 + W P G LAS D V +W G W + H +V +V W P + L Sbjct: 61 VDWAHPKFGTILASCSYDGKVLIWKEENG--RWSQIAVHAVHSASVNSVQWAPHEYGPLL 118 Query: 373 TGGGTSDRHIRIWNVCSGACLS--AVDAHS-QVCSILWSP-------------HYKELIS 416 +SD + + S +DAH+ V S W+P ++ ++ Sbjct: 119 LVA-SSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVT 177 Query: 417 GHGFAQNQLVIWKYPTMAKV----AELKGHTSRVLSLTMSPDG---ATVASAAADETLRL 469 G A N + IWKY + A+ + L+GH+ V + SP + +AS + D T + Sbjct: 178 --GGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII 235 Query: 470 W 470 W Sbjct: 236 W 236 Score = 116 bits (291), Expect = 2e-26, Method: Composition-based stats. Identities = 54/278 (19%), Positives = 88/278 (31%), Gaps = 32/278 (11%) Query: 224 QPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV--QQQKRLRNMTSHSARVGSLSW----N 277 E I G LA +S +++++V + K + +T H V + W Sbjct: 9 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 68 Query: 278 SYILSSGSRSGHIHHHDVRVAEHHVATLSG-HSQEVCGLRWAPD--GRHLASGGNDNLVN 334 IL+S S G + + HS V ++WAP G L +D V+ Sbjct: 69 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 128 Query: 335 VWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP----------WQSNVLATGGGTSDRHIRI 384 V E G H V + +W P G +D ++I Sbjct: 129 V--VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 186 Query: 385 W----NVCSGACLSAVDAHSQ-VCSILWSPHYKE-LISGHGFAQNQLVIW--KYPTMAKV 436 W + + S ++ HS V + WSP +IW Sbjct: 187 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 246 Query: 437 AELKGHT---SRVLSLTMSPDGATVASAAADETLRLWR 471 L + + S G +A + D + LW+ Sbjct: 247 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 284 Score = 32.1 bits (71), Expect = 0.53, Method: Composition-based stats. Identities = 6/40 (15%), Positives = 18/40 (45%) Query: 433 MAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 + V H + + G +A+ ++D+T++++ Sbjct: 1 GSMVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEV 40 >6BX3-A nrPDB Length = 314 Score = 141 bits (354), Expect = 9e-34, Method: Composition-based stats. Identities = 60/303 (19%), Positives = 108/303 (35%), Gaps = 36/303 (11%) Query: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 252 G LA+ ++ ++ + + Q L S + W +G +A + V++ Sbjct: 22 PDGQFLAITQGLNILIYDINRRTVSQTLV-TSHARPFSELCWSPDGQCIATASDDFSVEI 80 Query: 253 WDVQQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQ 310 + L H+A V SL++N +L + S I D + T+S HS+ Sbjct: 81 IHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSL-MKTISAHSE 138 Query: 311 EVCGLRW-APDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGA--------VKAV 361 V + D L+SG D L+ ++ + G L+T T + + V Sbjct: 139 AVVSVDVPMNDSSILSSGSYDGLIRIFDAETGH----CLKTLTYDKDWKRENGVVPISQV 194 Query: 362 AWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVD---------AHSQVCSILWSPHYK 412 + +L + D ++IW+ G + HS L Sbjct: 195 KFSENARYLL---VKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGS 251 Query: 413 ELISGHGFAQNQLVIWKYPTMAKVAELKG----HTSRVLSLTMSPDGATVASAAADETLR 468 + G+ + W T + + L G H+S V+S+ G + S A + Sbjct: 252 TPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCF--GNIMCSLALNGDCC 309 Query: 469 LWR 471 LWR Sbjct: 310 LWR 312 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 53/272 (19%), Positives = 105/272 (38%), Gaps = 33/272 (12%) Query: 222 MEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNM-TSHSARVGSLSW--NS 278 Q G + +G +LA+ T + ++D+ ++ + + TSH+ L W + Sbjct: 8 GTQNGLKATCAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDG 66 Query: 279 YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 +++ S + + ++ + T GH+ V L + G L + D + +W + Sbjct: 67 QCIATASDDFSVEI--IHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDT 124 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 G ++T + H AV +V S++L++ G+ D IRI++ +G CL + Sbjct: 125 LNG----SLMKTISAHSEAVVSVDVPMNDSSILSS--GSYDGLIRIFDAETGHCLKTLTY 178 Query: 399 HSQ---------VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL------KG-- 441 + + +S + + L+ + IW V KG Sbjct: 179 DKDWKRENGVVPISQVKFSENARYLLVKS--LDGVVKIWDCIGGCVVRTFQVQPLEKGVL 236 Query: 442 HTSRVLSLTMSPDGAT--VASAAADETLRLWR 471 H S + DG+T V S + + W Sbjct: 237 HHSCGMDFLNPEDGSTPLVISGYENGDIYCWN 268 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 37/222 (16%), Positives = 80/222 (36%), Gaps = 17/222 (7%) Query: 259 KRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWA 318 + A +S + L+ I +D+ ++ H++ L W+ Sbjct: 5 TPVGTQNGLKATCAKISPDGQFLAITQGLN-ILIYDINRRTVSQTLVTSHARPFSELCWS 63 Query: 319 PDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTS 378 PDG+ +A+ +D V + + L TF H V ++ + + + + + Sbjct: 64 PDGQCIATASDDFSVEI-----IHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTS---SM 115 Query: 379 DRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAE 438 D I+IW+ +G+ + + AHS+ + P I G + I+ T + Sbjct: 116 DESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKT 175 Query: 439 LKGHTSR--------VLSLTMSPDGATVASAAADETLRLWRC 472 L + + S + + + D +++W C Sbjct: 176 LTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDC 217 Score = 74.8 bits (182), Expect = 8e-14, Method: Composition-based stats. Identities = 28/185 (15%), Positives = 67/185 (36%), Gaps = 12/185 (6%) Query: 313 CGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLA 372 + +PDG+ LA N++ ++ + T H + W P Sbjct: 16 TCAKISPDGQFLAITQGLNIL-IYDINRRTVSQTLV---TSHARPFSELCWSPDGQ---C 68 Query: 373 TGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYP 431 + D + I ++ G L H+ V S+ ++ L + + IW Sbjct: 69 IATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSS--MDESIKIWDTL 125 Query: 432 TMAKVAELKGHTSRVLSLTM-SPDGATVASAAADETLRLWRCFELDPARRREREKASAAK 490 + + + H+ V+S+ + D + ++S + D +R++ + +K + Sbjct: 126 NGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRE 185 Query: 491 SSLIH 495 + ++ Sbjct: 186 NGVVP 190 >4BZK-B nrPDB Length = 297 Score = 139 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 54/270 (20%), Positives = 95/270 (35%), Gaps = 32/270 (11%) Query: 189 LVDWSSGNVLAVALDNSVYLWSASSGDILQLLQ-MEQPGEYISSVAWIKE--GNYLAVGT 245 ++D+ + + D ++ ++ G+ +L+ + + V W G LA + Sbjct: 16 VLDYYGKRLATCSSDKTIKIFEVE-GETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCS 74 Query: 246 SSAEVQLWDVQQQ--KRLRNMTSHSARVGSLSWNSY----ILSSGSRSGHIHHHDVR-VA 298 +V +W + ++ HSA V S+ W + +L S G + + + Sbjct: 75 YDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENG 134 Query: 299 EHHVATLSGHSQEVCGLRWAP-------------DGRHLASGGNDNLVNVWPSAPGEGGW 345 + H+ V WAP + R +GG DNLV +W + Sbjct: 135 TTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTY 194 Query: 346 VPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW--NVCSGACLSAVDAHSQVC 403 V T H V+ VAW P + DR IW + G + + Sbjct: 195 VLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFP 254 Query: 404 SIL----WSPHYKELISGHGFAQNQLVIWK 429 +L WS L G N++ +WK Sbjct: 255 DVLWRASWSLSGNVLALSGG--DNKVTLWK 282 Score = 114 bits (285), Expect = 1e-25, Method: Composition-based stats. Identities = 54/278 (19%), Positives = 88/278 (31%), Gaps = 32/278 (11%) Query: 224 QPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV--QQQKRLRNMTSHSARVGSLSW----N 277 E I G LA +S +++++V + K + +T H V + W Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 278 SYILSSGSRSGHIHHHDVRVAEHHVATLSG-HSQEVCGLRWAPD--GRHLASGGNDNLVN 334 IL+S S G + + HS V ++WAP G L +D V+ Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 335 VWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP----------WQSNVLATGGGTSDRHIRI 384 V E G H V + +W P G +D ++I Sbjct: 127 V--VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 Query: 385 W----NVCSGACLSAVDAHSQ-VCSILWSPHYKE-LISGHGFAQNQLVIW--KYPTMAKV 436 W + + S ++ HS V + WSP +IW Sbjct: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 244 Query: 437 AELKGHT---SRVLSLTMSPDGATVASAAADETLRLWR 471 L + + S G +A + D + LW+ Sbjct: 245 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 Score = 30.5 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 6/38 (15%), Positives = 17/38 (44%) Query: 435 KVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 V H + + G +A+ ++D+T++++ Sbjct: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEV 38 >6ELZ-p nrPDB Length = 460 Score = 138 bits (348), Expect = 5e-33, Method: Composition-based stats. Identities = 52/327 (15%), Positives = 99/327 (30%), Gaps = 68/327 (20%) Query: 226 GEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS-WNSYILSSG 284 +++SS+ ++ G+ V+ WD+ + + HS + ++ ++ L S Sbjct: 103 EDWVSSLDVGDGSKHIISGSYDGIVRTWDL-SGNVQKQYSGHSGPIRAVKYISNTRLVSA 161 Query: 285 SRSGHIHHHDVRVAE----------------------HHVATLSGHSQEVCGLRWAPDGR 322 + + + +A L GH V + + D Sbjct: 162 GNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVS-DNS 220 Query: 323 HLASGGNDNLVNVWPSAPGEGGWV----------------------------------PL 348 + S DN + W + E V PL Sbjct: 221 RILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGTIRRRAPL 280 Query: 349 QTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWS 408 H V+ V + + V + + D I+ W++ + C+ + SI Sbjct: 281 SLLESHTAPVEQVIFDSTDNTVGYSV--SQDHTIKTWDLVTARCIDTRTTSYSLLSIAQL 338 Query: 409 PHYKELISGHGFAQNQLVIWKYP----TMAKVAELKGHTSRVLSLTMSP-DGATVASAAA 463 L G + + + +L GH + V SL P + + S + Sbjct: 339 STLNLLACGSSAR--HITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSH 396 Query: 464 DETLRLWRCFELDPARRREREKASAAK 490 D T+++W P RE S K Sbjct: 397 DGTVKVWDVRSTSPMYTITREDKSVQK 423 Score = 79.1 bits (193), Expect = 4e-15, Method: Composition-based stats. Identities = 34/151 (22%), Positives = 58/151 (38%), Gaps = 18/151 (11%) Query: 199 AVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWD---- 254 +V+ D+++ W + + + S+A + N LA G+S+ + L D Sbjct: 305 SVSQDHTIKTWDLVTARC---IDTRTTSYSLLSIAQLSTLNLLACGSSARHITLHDPRVG 361 Query: 255 VQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVATL------ 305 + + + H V SL N YIL SGS G + DVR Sbjct: 362 ASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSV 421 Query: 306 -SGHSQEVCGLRWAPDGRHLASGGNDNLVNV 335 G + +V ++WA + S G D + + Sbjct: 422 QKGVNDKVFAVKWAEKVG-IISAGQDKKIQI 451 Score = 76.4 bits (186), Expect = 3e-14, Method: Composition-based stats. Identities = 34/170 (20%), Positives = 61/170 (35%), Gaps = 8/170 (4%) Query: 222 MEQPGEYISSVAW-IKEGNYLAVGTSSAEVQLWDVQQQKRL--RNMTSHSARVGSLSWNS 278 +E + V + + + ++ WD+ + + R + + LS + Sbjct: 283 LESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYSLLSIAQLSTLN 342 Query: 279 YILSSGSRSGHIHHHDVRVAEHHVAT---LSGHSQEVCGLRWAPDGRHLA-SGGNDNLVN 334 +L+ GS + HI HD RV T L GH V L P+ ++ SG +D V Sbjct: 343 -LLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVK 401 Query: 335 VWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRI 384 VW + + Q V + + + D+ I+I Sbjct: 402 VWDVRSTSPMYTITREDKSVQKGVNDKVFAVKWAEKVGIISAGQDKKIQI 451 >1NR0-A nrPDB Length = 611 Score = 138 bits (347), Expect = 7e-33, Method: Composition-based stats. Identities = 57/316 (18%), Positives = 101/316 (31%), Gaps = 64/316 (20%) Query: 214 GDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLR--NMTSHSARV 271 G + + + G Y A G V++WD Q + + S V Sbjct: 47 GSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPV 106 Query: 272 GSLSWN-----------------------------------------------SYILSSG 284 +SW+ + + SG Sbjct: 107 KDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISG 166 Query: 285 SRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG 344 S + + +T H++ V +R+ PDG AS G D + ++ G Sbjct: 167 SDDNTVAIFE-GPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKT 225 Query: 345 WVPL---QTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ 401 V H G+V + W P + + ++D+ I+IWNV + + ++ Sbjct: 226 GVFEDDSLKNVAHSGSVFGLTWSPDGTKI---ASASADKTIKIWNVATLKVEKTIPVGTR 282 Query: 402 V----CSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGAT 457 + I+W+ IS +GF + GH + +L+ S DG T Sbjct: 283 IEDQQLGIIWTKQALVSISANGFINFV----NPELGSIDQVRYGHNKAITALSSSADGKT 338 Query: 458 VASAAADETLRLWRCF 473 + SA A+ + W Sbjct: 339 LFSADAEGHINSWDIS 354 Score = 109 bits (271), Expect = 4e-24, Method: Composition-based stats. Identities = 50/235 (21%), Positives = 89/235 (37%), Gaps = 19/235 (8%) Query: 257 QQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVAT-LSGHSQEVCGL 315 + SH V S + Y +SG G++ D H + T + S V + Sbjct: 50 TDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDI 109 Query: 316 RWAPDGRHLASGGN--DNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLAT 373 W + + +A+ G + +V+ G T A+ +V + P + Sbjct: 110 SWDSESKRIAAVGEGRERFGHVFLFDTGTSNG----NLTGQARAMNSVDFKPSRP--FRI 163 Query: 374 GGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPT 432 G+ D + I+ S H++ V S+ ++P S G +V++ Sbjct: 164 ISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGG--DGTIVLYNGVD 221 Query: 433 MAKVAELK-------GHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 K + H+ V LT SPDG +ASA+AD+T+++W L + Sbjct: 222 GTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKT 276 Score = 88.7 bits (218), Expect = 5e-18, Method: Composition-based stats. Identities = 54/427 (12%), Positives = 131/427 (30%), Gaps = 94/427 (22%) Query: 138 QNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNV 197 A K + GS T P + + ++ G++ Sbjct: 145 GQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSL 204 Query: 198 L-AVALDNSVYLWSASSGDILQLLQME-----QPGEYISSVAWIKEGNYLAVGTSSAEVQ 251 + D ++ L++ G + + + + + W +G +A ++ ++ Sbjct: 205 FASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIK 264 Query: 252 LWDVQQQKRLRNM-------------------------------------------TSHS 268 +W+V K + + H+ Sbjct: 265 IWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHN 324 Query: 269 ARVGSLS--WNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLAS 326 + +LS + L S GHI+ D+ + H+ + G++ G + Sbjct: 325 KAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLF-T 383 Query: 327 GGNDNLVNVWPS----------APGEGGWVPLQ------------------TFTQHQGAV 358 D+ + V P+ + PL H G + Sbjct: 384 VSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSH-GKL 442 Query: 359 KAVAWCPWQSNVLAT------GGGTSDRHIRIWNV--CSGACLSAVDAHSQVCSILWSPH 410 V S V + G D + ++ + S + + + +++ S+ +S + Sbjct: 443 TEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNN 502 Query: 411 YKELISGHGFAQNQLVIWKYPTMAKVAELKG---HTSRVLSLTMSPDGATVASAAADETL 467 L++ +++ + ++A HT++V ++ SPD +A+ + D ++ Sbjct: 503 GAFLVAT--DQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSV 560 Query: 468 RLWRCFE 474 +W + Sbjct: 561 IVWNMNK 567 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 71/407 (17%), Positives = 142/407 (34%), Gaps = 70/407 (17%) Query: 121 NGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYS-QKATPGSSRKTCRYIPSLPDRILDAP 179 NG D + + A G L K S+ KT + ++ Sbjct: 218 NGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTI 277 Query: 180 EI---RNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK 236 + D L ++ W+ +++++ + + + G I Q+ + I++++ Sbjct: 278 PVGTRIEDQQLGII-WTKQALVSISANGFINFVNPELGSIDQV--RYGHNKAITALSSSA 334 Query: 237 EGNYLAVGTSSAEVQLWDVQQQKRLRNM------------TSHSARVGSLSWNSYI---- 280 +G L + + WD+ R T+ + ++SW+ ++ Sbjct: 335 DGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVP 394 Query: 281 ---------------LSS------GSRSGHIHHHDVRVAEHHVATL-SGHSQEV------ 312 LSS S G I V H+A G EV Sbjct: 395 AGGSGVDSSKAVANKLSSQPLGLAVSADGDIA---VAACYKHIAIYSHGKLTEVPISYNS 451 Query: 313 CGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLA 372 + + D + +A GG D+ V+V+ + ++T H + +VA+ + ++A Sbjct: 452 SCVALSNDKQFVAVGGQDSKVHVYKLSG--ASVSEVKTIV-HPAEITSVAFSNNGAFLVA 508 Query: 373 TGGGTSDRHIRIWNVCSGACLSAVD----AHSQVCSILWSPHYKELISGHGFAQNQLVIW 428 T R + ++V + L+ + ++V + WSP L G N +++W Sbjct: 509 TDQS---RKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRL--ATGSLDNSVIVW 563 Query: 429 KY--PTMAKVAELKGH-TSRVLSLTMSPDGATVASAAADETLRLWRC 472 P+ + H S V S+ + T+ SA D ++ W Sbjct: 564 NMNKPSDHPIIIKGAHAMSSVNSVIWL-NETTIVSAGQDSNIKFWNV 609 Score = 45.9 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 20/161 (12%), Positives = 41/161 (25%), Gaps = 11/161 (6%) Query: 343 GGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-----GACLSAVD 397 G + +T+H + G ++RIW+ + Sbjct: 47 GSLTDTEIYTEHSH---QTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFS 103 Query: 398 AHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA- 456 V I W K + + + ++ + T L G + S+ P Sbjct: 104 G--PVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPF 161 Query: 457 TVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 + S + D T+ ++ G Sbjct: 162 RIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDG 202 >3ODT-A nrPDB Length = 313 Score = 131 bits (330), Expect = 5e-31, Method: Composition-based stats. Identities = 51/285 (17%), Positives = 100/285 (35%), Gaps = 33/285 (11%) Query: 196 NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQ---L 252 V +V+ D +V LWS L + G +++SV + E L G + L Sbjct: 31 KVASVSRDGTVRLWS-KDDQWLGTVVYTGQG-FLNSVCYDSEKELLLFGGKDTMINGVPL 88 Query: 253 WDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEV 312 + + L + H V SLS+ ++ SGS V L H+ V Sbjct: 89 FATSGEDPLYTLIGHQGNVCSLSFQDGVVISGSWDKTAKVW---KEGSLVYNLQAHNASV 145 Query: 313 CG---LRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ-HQGAVKAVAWCPWQS 368 + ++ + + D + +W ++TF+ H V+ +A Sbjct: 146 WDAKVVSFSEN--KFLTASADKTIKLW------QNDKVIKTFSGIHNDVVRHLAVVDDGH 197 Query: 369 NVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVI 427 + ++D I++ ++ +G L + H V I P+ + I Sbjct: 198 FI----SCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD---IVSCGEDRTVRI 250 Query: 428 WKYPTM--AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 W +V L + S+ +G + ++D +R++ Sbjct: 251 WSKENGSLKQVITLPA--ISIWSVDCMSNGDIIV-GSSDNLVRIF 292 Score = 91.4 bits (225), Expect = 9e-19, Method: Composition-based stats. Identities = 43/245 (17%), Positives = 84/245 (34%), Gaps = 22/245 (8%) Query: 259 KRLRNMTSHSARVGSLSWNS-YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRW 317 + + H V + ++S SR G + +G + + + Sbjct: 9 QLSATLKGHDQDVRDVVAVDDSKVASVSRDGTVRLWSKDDQWLGTVVYTG-QGFLNSVCY 67 Query: 318 APDGRHLASGGNDNLVNVWPSAP--GEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGG 375 + L GG D ++ P G PL T HQG V ++++ Sbjct: 68 DSEKELLLFGGKDTMI---NGVPLFATSGEDPLYTLIGHQGNVCSLSFQDG-----VVIS 119 Query: 376 GTSDRHIRIWNVCSGACLSAVDAHSQVC--SILWSPHYKELISGHGFAQNQLVIWKYPTM 433 G+ D+ ++W G+ + + AH+ + + S + ++ A + +W Sbjct: 120 GSWDKTAKVW--KEGSLVYNLQAHNASVWDAKVVSFSENKFLTAS--ADKTIKLW--QND 173 Query: 434 AKVAELKG-HTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSS 492 + G H V L + DG + S + D ++L D R E ++ Sbjct: 174 KVIKTFSGIHNDVVRHLAVVDDGHFI-SCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIK 232 Query: 493 LIHQG 497 L+ G Sbjct: 233 LLPNG 237 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 19/99 (19%), Positives = 46/99 (46%), Gaps = 3/99 (3%) Query: 160 SSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQL 219 S+ + + +L E + + +G++++ D +V +WS +G + Q+ Sbjct: 202 SNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGDIVSCGEDRTVRIWSKENGSLKQV 261 Query: 220 LQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQ 258 + + P I SV + G+ + VG+S V+++ ++ Sbjct: 262 ITL--PAISIWSVDCMSNGDII-VGSSDNLVRIFSQEKS 297 >3BG0-A nrPDB Length = 316 Score = 131 bits (329), Expect = 8e-31, Method: Composition-based stats. Identities = 58/279 (20%), Positives = 99/279 (35%), Gaps = 48/279 (17%) Query: 190 VDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKE--GNYLAVGTSS 247 +D+ + + D SV ++ +G + + + + VAW GN LA + Sbjct: 21 MDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYD 80 Query: 248 AEVQLWDVQQQ--KRLRNMTSHSARVGSLSWNSY----ILSSGSRSGHIHH--------H 293 +V +W + ++ H + V S+ W + IL+ GS G I Sbjct: 81 RKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQW 140 Query: 294 DVRVAEHHVATLSGHSQEVCGLRW-----------APDG------RHLASGGNDNLVNVW 336 +V+ + H+ + W P G + ASGG DNL+ +W Sbjct: 141 EVKKINN------AHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW 194 Query: 337 PSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLAT-GGGTSDRHIRIWNV-----CSG 390 +G W Q H V+ VAW P +T + D + IW + Sbjct: 195 KEE-EDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTW 253 Query: 391 ACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWK 429 + + V + WS L G N++ +WK Sbjct: 254 SPKLLHKFNDVVWHVSWSITANILAVSGG--DNKVTLWK 290 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 52/285 (18%), Positives = 93/285 (32%), Gaps = 40/285 (14%) Query: 223 EQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQK--RLRNMTSHSARVGSLSWN--- 277 + I G LA +S V+++DV+ + ++ H V ++W Sbjct: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 Query: 278 -SYILSSGSRSGHIHHHDVRVAEHHVATLS-GHSQEVCGLRWAPDGR--HLASGGNDNLV 333 IL+S S + + GH V + WAP LA G +D + Sbjct: 70 YGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 Query: 334 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP--------------WQSNVLATGGGTSD 379 ++ + GEG W + H AV+W P + + G D Sbjct: 130 SL-LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCD 188 Query: 380 RHIRIWN---VCSGACLSAVDAHSQ-VCSILWSPH--YKELISGHGFAQNQLVIWKYP-- 431 I++W ++AHS V + W+P ++ IW Sbjct: 189 NLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDA 248 Query: 432 -----TMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 + + + V ++ S +A + D + LW+ Sbjct: 249 SSNTWSPKLLHKF---NDVVWHVSWSITANILAVSGGDNKVTLWK 290 Score = 113 bits (283), Expect = 2e-25, Method: Composition-based stats. Identities = 49/230 (21%), Positives = 79/230 (34%), Gaps = 40/230 (17%) Query: 278 SYILSSGSRSGHIHHHDVRVAEH-HVATLSGHSQEVCGLRW-AP-DGRHLASGGNDNLVN 334 L++ S + DVR +A L GH V + W P G LAS D V Sbjct: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84 Query: 335 VWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRI--------WN 386 +W G W H +V +V W P ++ G+SD I + W Sbjct: 85 IWREENG--TWEKSHEHAGHDSSVNSVCWAPHDYGLILAC-GSSDGAISLLTYTGEGQWE 141 Query: 387 VCSGACLSAVDAHSQVCSILWSP-------------HYKELI--SGHGFAQNQLVIWKYP 431 V + ++ W+P I G N + +WK Sbjct: 142 VKKINNAHTI----GCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEE 197 Query: 432 T---MAKVAELKGHTSRVLSLTMSPD----GATVASAAADETLRLWRCFE 474 + +L+ H+ V + +P +T+AS + D + +W C + Sbjct: 198 EDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD 247 Score = 87.5 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 44/205 (21%), Positives = 76/205 (37%), Gaps = 28/205 (13%) Query: 306 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAW-C 364 + H + + G LA+ +D V ++ G G + + H+G V VAW Sbjct: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNG--GQILIADLRGHEGPVWQVAWAH 67 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA---HSQVCSILWSPHYKELISGHGFA 421 P N+LA+ + DR + IW +G + + S V S+ W+PH LI G + Sbjct: 68 PMYGNILASC--SYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSS 125 Query: 422 QNQLVIWKY---PTMAKVAELKGHTSRVLSLTM-----------SPDG------ATVASA 461 + + Y HT +++ P G AS Sbjct: 126 DGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASG 185 Query: 462 AADETLRLWRCFELDPARRREREKA 486 D ++LW+ E + ++ +A Sbjct: 186 GCDNLIKLWKEEEDGQWKEEQKLEA 210 Score = 42.1 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 33/79 (41%), Gaps = 2/79 (2%) Query: 177 DAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLW--SASSGDILQLLQMEQPGEYISSVAW 234 + +R+ + + + + + + D V++W +S + + + + + V+W Sbjct: 211 HSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSW 270 Query: 235 IKEGNYLAVGTSSAEVQLW 253 N LAV +V LW Sbjct: 271 SITANILAVSGGDNKVTLW 289 Score = 33.6 bits (75), Expect = 0.21, Method: Composition-based stats. Identities = 5/48 (10%), Positives = 16/48 (33%) Query: 442 HTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAA 489 H + M G +A+ ++D +++++ + Sbjct: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGP 59 >5OQL-d nrPDB Length = 446 Score = 126 bits (315), Expect = 3e-29, Method: Composition-based stats. Identities = 49/272 (18%), Positives = 105/272 (38%), Gaps = 19/272 (6%) Query: 224 QPGEYISSVAWIKEG-NYLAVGTSSAEVQLWDVQQQ-KRLRNMTSHSARVGSLSW-NSYI 280 + + S+ K N +A G+ V++WD+ + + + +H+ V L++ N Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTNDKK 123 Query: 281 LSSGSRSGHIHHHD-VRVAEHHVATLSGHSQ-EVCGLRWAPDGRHLASGGNDNLVNVWPS 338 L S + G I D + + L + A+ + +W Sbjct: 124 LLSCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWDL 182 Query: 339 A-PGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVD 397 G + +F + V + +++V+ G +DR I ++++ + + Sbjct: 183 EHSTAGQAIQWPSFV---DTITDVCFNQVETSVI--GSVATDRSIILFDLRTNMPVIKTV 237 Query: 398 AHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL-KGHTSRVLSLTMSPDGA 456 H I+++P + + + + I+ K + KGH + V+ + SP G Sbjct: 238 LHFACNRIVFNP-MEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGE 296 Query: 457 TVASAAADETLRLWR-----CFELDPARRRER 483 + S + D T+RLWR ++ +R +R Sbjct: 297 ELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQR 328 Score = 111 bits (278), Expect = 6e-25, Method: Composition-based stats. Identities = 51/332 (15%), Positives = 114/332 (34%), Gaps = 29/332 (8%) Query: 181 IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY 240 ++ Y + S + + + D V +W ++ D + ++ + + + + Sbjct: 66 VQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRD-EETWRVAAHNNIVKGLTFTNDKKL 124 Query: 241 LAVGTSSAEVQLWD-VQQQKRLRNMTSHS--ARVGSLSWN--SYILSSGSRSGHIHHHDV 295 L + ++LWD + + SLS++ + ++ S G I D+ Sbjct: 125 L-SCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWDL 182 Query: 296 RVAE-HHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ 353 + + + + + + S D + ++ + F Sbjct: 183 EHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHF-- 240 Query: 354 HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAVDAH-SQVCSILWSPHY 411 A + + P ++ LA + D +I I++ + L+ H + V + +SP Sbjct: 241 ---ACNRIVFNPMEAMNLAVA--SEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTG 295 Query: 412 KELISGHGFAQNQLVIWKYPTMAKVAELKGHTSR---VLSLTMSPDGATVASAAADETLR 468 +EL+SG + +W+ HT R V + D + + + D +R Sbjct: 296 EELVSGS--YDRTIRLWRRDAGHSRDVY--HTKRMQRVFRTMWTMDSKYILTGSDDGNVR 351 Query: 469 LWRC---FELDPARRREREKASAAKSSLIHQG 497 LWR R+R+ + L G Sbjct: 352 LWRANASERSGVKATRQRQALEYNNALLDRYG 383 Score = 49.4 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 15/76 (19%), Positives = 26/76 (34%), Gaps = 3/76 (3%) Query: 397 DAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVA-ELKGHTSRVLSLTMSPDG 455 + H Q + G + +W T + + H + V LT + D Sbjct: 63 NGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTND- 121 Query: 456 ATVASAAADETLRLWR 471 + S A D ++LW Sbjct: 122 KKLLSCATDG-IKLWD 136 >5WLC-LJ nrPDB Length = 513 Score = 124 bits (311), Expect = 9e-29, Method: Composition-based stats. Identities = 43/273 (15%), Positives = 116/273 (42%), Gaps = 21/273 (7%) Query: 217 LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW 276 Q+ + ++ +++ + + TSS VQ++ + ++ ++ + V S S+ Sbjct: 30 YTSAQLVKEHNSVTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIKTFSRFKDVVYSASF 89 Query: 277 --NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWA-PDGRHLASGGNDNLV 333 + +L +G +G + +D + +++ + ++ D + LA+ +D + Sbjct: 90 RSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKILATASDDRVT 149 Query: 334 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS--GA 391 +W + + P T V+ +++ P +++AT G+ D IR+++ S Sbjct: 150 RLWDISN---AYEPQLELTGATDYVRTLSFIPAAPHLVAT--GSYDGLIRLYDTRSSGST 204 Query: 392 CLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTM 451 + +++ V +++ + +++S G N +W + K+ E V L Sbjct: 205 PIYSLNHDQPVENVI-AVSPTQIVSCGG---NNFKVWDLTSNKKLYERGNFNKAVTCLDY 260 Query: 452 -----SPDGATVASAAADETLRLWRCFELDPAR 479 SP + + +++ D ++++ LD + Sbjct: 261 VENFDSPMQSALIASSLDGHVKVFD--PLDNFQ 291 Score = 98.3 bits (243), Expect = 6e-21, Method: Composition-based stats. Identities = 50/309 (16%), Positives = 117/309 (37%), Gaps = 34/309 (11%) Query: 198 LAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQ 257 AV V ++S+ + +++ + + S ++ +G L G ++ V ++D Sbjct: 55 FAVTSSTRVQIFSSRTRQVIKTFSRF--KDVVYSASFRSDGKLLCAGDATGLVSVYDSYN 112 Query: 258 QKRLR---NMTSHSARVGSL-SWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVC 313 + + N ++H V + ++ IL++ S D+ A L+G + V Sbjct: 113 PRTILLSINASTHPTHVTKFHTQDNKILATASDDRVTRLWDISNAYEPQLELTGATDYVR 172 Query: 314 GLRWAPDGRHLA-SGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAV-KAVAWCPWQSNVL 371 L + P HL +G D L+ ++ + G P+ + H V +A P + ++ Sbjct: 173 TLSFIPAAPHLVATGSYDGLIRLYDTRS--SGSTPIYSL-NHDQPVENVIAVSP--TQIV 227 Query: 372 ATGGGTSDRHIRIWNVCSGACLSAV-DAHSQVCSILWSPHYKELISG---HGFAQNQLVI 427 + GG + ++W++ S L + + V + + ++ + + + Sbjct: 228 SCGG----NNFKVWDLTSNKKLYERGNFNKAVTCLDYVENFDSPMQSALIASSLDGHVKV 283 Query: 428 WKYPTMAKVA---ELKGHTSRVLSLTMSPD----GATVASAAADETLRLWRCFELDPARR 480 + +V + G VLS +SP + + + L + +R Sbjct: 284 FDPLDNFQVKFGWKFSG---PVLSCAVSPSTAQGNRHLVAGLSSGLLAI---RTKKKEKR 337 Query: 481 REREKASAA 489 ++ + A Sbjct: 338 SSDKENAPA 346 Score = 73.3 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 26/199 (13%), Positives = 66/199 (33%), Gaps = 17/199 (8%) Query: 180 EIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEG- 238 + + + + D LW S+ L++ +Y+ ++++I Sbjct: 123 STHPTHVTKFHTQDNKILATASDDRVTRLWDISNA-YEPQLELTGATDYVRTLSFIPAAP 181 Query: 239 NYLAVGTSSAEVQLWDVQQ--QKRLRNMTSHSARV-GSLSWNSYILSSGSRSGHIHHHDV 295 + +A G+ ++L+D + + ++ H V ++ + + S + D+ Sbjct: 182 HLVATGSYDGLIRLYDTRSSGSTPIYSLN-HDQPVENVIAVSPTQIVSCGGNNF-KVWDL 239 Query: 296 RVAEHHVATLSGHSQEVCGLRW-----APDGRHLASGGNDNLVNVWPSAPGEGGWVPLQT 350 + + ++ V L + +P L + D V V+ + Sbjct: 240 -TSNKKLYERGNFNKAVTCLDYVENFDSPMQSALIASSLDGHVKVFDPLDNFQVKFGWK- 297 Query: 351 FTQHQGAVKAVAWCPWQSN 369 G V + A P + Sbjct: 298 ---FSGPVLSCAVSPSTAQ 313 >4XFV-A nrPDB Length = 792 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 48/207 (23%), Positives = 72/207 (34%), Gaps = 27/207 (13%) Query: 288 GHIHHHDVRVAEHH--VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGW 345 I D + ATL GH EV +R+ PD + S D+ V +W Sbjct: 40 KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF-TDYSHL 98 Query: 346 VPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW--NVCSGACLSAVDAH---- 399 +QT + + A++ P G +D I IW N+ + A + Sbjct: 99 QCIQTIQHYSKTIVALSALPS-----LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKG 153 Query: 400 --SQVCSILWSPHYKELISGHGFAQNQLVIWK-------YPTMAKVAELKGHTSRVLSLT 450 +C L K+ + G + I VAEL+GH V SL Sbjct: 154 FFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLA 213 Query: 451 M----SPDGATVASAAADETLRLWRCF 473 +P + S + D +RLWR Sbjct: 214 FRHQETPGDYLLCSGSQDRYIRLWRIR 240 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 51/296 (17%), Positives = 107/296 (36%), Gaps = 34/296 (11%) Query: 196 NVLAVALDNSVYLWS-ASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW- 253 ++A ++ LW + ++ ++ V ++ + +++ + V++W Sbjct: 32 KIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 91 Query: 254 --DVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQE 311 D + ++ + +S + +LS ++S G G I + H Sbjct: 92 FTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGL--AHEFT 149 Query: 312 V-------CGLRWA---PDGRHLASGGNDNLVNVWP-----SAPGEGGWVPLQTFTQHQG 356 + L + LA GG + VNV+ S G + H+ Sbjct: 150 IKKGFFYPLCLSLSKVEEKKYLLAIGGTN--VNVFIASFILSDSGIEKCRVVAELEGHED 207 Query: 357 AVKAVAW-CPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELI 415 VK++A+ G+ DR+IR+W + + + S+ ++L + YK I Sbjct: 208 WVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQI 267 Query: 416 SGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 ++L + A + GH + SL + +A AD +L +W Sbjct: 268 ------DDELRV-GINFEALIM---GHDDWISSLQWHESRLQLLAATADTSLMVWE 313 Score = 86.4 bits (212), Expect = 3e-17, Method: Composition-based stats. Identities = 33/233 (14%), Positives = 78/233 (33%), Gaps = 23/233 (9%) Query: 221 QMEQPGEYISSVAWIKEGNYLAVGTSSAEV-----QLWDVQQQKRLR-NMTSHSARVGSL 274 ++ G I+ + + +A S V +++ + ++ + HS + L Sbjct: 557 KLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRL 616 Query: 275 SW--NSYILSSGSRSGHIHHHDVRVAEH----HVATLSGHSQEVCGLRWAP--DGRHLAS 326 + + L S R + + ++ H++ + WAP G + Sbjct: 617 KFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVT 676 Query: 327 GGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQ-SNVLATGGGTSDRHIRIW 385 D V VW L+ +H AV A++ + G + I ++ Sbjct: 677 ASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLY 736 Query: 386 N--VCSGACLSAVDAH----SQVCSILWSPHYK--ELISGHGFAQNQLVIWKY 430 + + ++ ++ ++ + WS + +L G G + I+ Sbjct: 737 SYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSL 789 Score = 79.1 bits (193), Expect = 5e-15, Method: Composition-based stats. Identities = 58/392 (14%), Positives = 116/392 (29%), Gaps = 93/392 (23%) Query: 138 QNAPEGYQNRLKVLYSQKATPGSSR----KTCRYIPSLPDRILDAPEIRNDYYLNLVDWS 193 E ++ + +S K ++ + + + + + L Sbjct: 59 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP 118 Query: 194 SGNVLAVALDNSVYLW----SASSGDILQLLQMEQPGEYISSVAWIK---EGNYLAVGTS 246 S + A D ++ +W + +++ Y ++ K + LA+G + Sbjct: 119 SLISVGCA-DGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGT 177 Query: 247 SAEVQLWD-------VQQQKRLRNMTSHSARVGSLSW------NSYILSSGSRSGHIHHH 293 + V + +++ + + + H V SL++ Y+L SGS+ +I Sbjct: 178 NVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 237 Query: 294 --------------------------------DVRVAEHHVATLSGHSQEVCGLRWAPDG 321 ++RV + A + GH + L+W Sbjct: 238 RIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESR 297 Query: 322 RHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRH 381 L + D + VW G WV + S +T G+S Sbjct: 298 LQLLAATADTSLMVWEPDETSGIWVCSLRLGEM------------SSKGASTATGSSGG- 344 Query: 382 IRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAE--- 438 W S LW H + +W + Sbjct: 345 --FW------------------SCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLG 384 Query: 439 LKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 + G T V + SP G + + + D+T RL+ Sbjct: 385 ISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 416 Score = 60.2 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 30/171 (17%), Positives = 64/171 (37%), Gaps = 22/171 (12%) Query: 337 PSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGT---SDRHIRIWNVCSGACL 393 W ++ H + + P ++A+ + + IRI++ + + Sbjct: 544 DQLQRHLLWPEVEKLYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEI 602 Query: 394 S-AVDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL-----KGHTSRV 446 A+ HS + + +S K L+S + +W+ EL K HT + Sbjct: 603 KPALPFHSLTITRLKFSKDGKFLLSV--CRDRKWALWERNMEDNTFELRFKNEKPHTRII 660 Query: 447 LSLTMSPD--GATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIH 495 +P G +A+ D+T+++WR ++E ++S+ H Sbjct: 661 WDADWAPLEFGNVFVTASRDKTVKVWR-------HQKEPADDYVLEASIKH 704 Score = 54.8 bits (130), Expect = 8e-08, Method: Composition-based stats. Identities = 28/181 (15%), Positives = 53/181 (29%), Gaps = 18/181 (9%) Query: 300 HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVN--VWPSAPGEGGWVPLQTFTQHQGA 357 V L GH E+ L +PD + +AS N V V E H Sbjct: 553 PEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLT 612 Query: 358 VKAVAWCPWQSNVLATGGGTSDRHIRIW--NVCSGACLSAVDAHSQ----VCSILWSPHY 411 + + + +L+ DR +W N+ + W+P Sbjct: 613 ITRLKFSKDGKFLLSV---CRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLE 669 Query: 412 KELISGHGFAQNQLVIWKYPTMAKVA-ELKG---HTSRVLSLTMSPD---GATVASAAAD 464 + + +W++ L+ HT V ++++ + S + Sbjct: 670 FGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLE 729 Query: 465 E 465 Sbjct: 730 N 730 Score = 30.1 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 15/79 (18%), Positives = 32/79 (40%), Gaps = 10/79 (12%) Query: 191 DWSS---GNV-LAVALDNSVYLWSA--SSGDILQLLQMEQPGEYISSVAWIKE----GNY 240 DW+ GNV + + D +V +W D L + + +++++ Sbjct: 664 DWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKIL 723 Query: 241 LAVGTSSAEVQLWDVQQQK 259 ++VG + E+ L+ K Sbjct: 724 ISVGLENGEIYLYSYTLGK 742 >5WBU-D nrPDB Length = 328 Score = 122 bits (307), Expect = 3e-28, Method: Composition-based stats. Identities = 41/265 (15%), Positives = 89/265 (33%), Gaps = 19/265 (7%) Query: 240 YLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGS--LSWNSYILSSGSRSGHIHHHDVRV 297 LA V+ W R + ++V + ++ + ++++ HI +D+ Sbjct: 16 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMYDLNS 74 Query: 298 AE-HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG 356 + + + G ++ + + + DGR + +GG D +W + F Sbjct: 75 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRN--LQCQRIFQV-NA 131 Query: 357 AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELIS 416 + V P Q+ ++ G I IW++ + + +V Sbjct: 132 PINCVCLHPNQAELI---VGDQSGAIHIWDLKTDHNEQLIP-EPEVSITSAHIDPDASYM 187 Query: 417 GHGFAQNQLVIWKYPTMA--------KVAELKGHTSRVLSLTMSPDGATVASAAADETLR 468 + +W ++ HT L SPD +A+ +AD+T + Sbjct: 188 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCK 247 Query: 469 LWRCFELDPARRREREKASAAKSSL 493 +WR + + +SS Sbjct: 248 IWRTSNFSLMTELSIKSGNPGESSR 272 Score = 121 bits (304), Expect = 6e-28, Method: Composition-based stats. Identities = 55/317 (17%), Positives = 117/317 (36%), Gaps = 40/317 (12%) Query: 161 SRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGN-VLAVALDNSVYLWSASSGDILQL 219 T R+ I D +N ++ + ++A A + ++ +S + + Sbjct: 22 YDHTVRFW-QAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPI 80 Query: 220 LQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQ--KRLRNMTSHSARVGSLSWN 277 + + + I+SV + ++G ++ G ++WD++ + + R +A + + + Sbjct: 81 ISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV-NAPINCVCLH 139 Query: 278 SYI--LSSGSRSGHIHHHDVRV-------AEHHVATLSGHSQEVCGLRWAPDGRHLASGG 328 L G +SG IH D++ E V+ S H PD ++A+ Sbjct: 140 PNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHID--------PDASYMAAVN 191 Query: 329 NDNLVNVWPSAPGEG----GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRI 384 + VW G G +P H + P S +LAT ++D+ +I Sbjct: 192 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATC--SADQTCKI 248 Query: 385 WNVCSGACLSAVDAHS---------QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAK 435 W + + ++ + S + +S + +++ + N +W T Sbjct: 249 WRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTAS--SDNLARLWCVETGEI 306 Query: 436 VAELKGHTSRVLSLTMS 452 E GH V+ L + Sbjct: 307 KREYGGHQKAVVCLAFN 323 Score = 116 bits (291), Expect = 2e-26, Method: Composition-based stats. Identities = 44/306 (14%), Positives = 105/306 (34%), Gaps = 34/306 (11%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256 + D++V W A SG + +Q + ++++ + + +A ++++D+ Sbjct: 17 LATAGYDHTVRFWQAHSGICTRTVQHQDSQ--VNALEVTPDRSMIAAAGY-QHIRMYDLN 73 Query: 257 QQKR--LRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEV 312 + + + + S+ + + + +G D+R + + + Sbjct: 74 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPI 133 Query: 313 CGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLA 372 + P+ L G +++W Q + + ++ + P S + A Sbjct: 134 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNE----QLIPEPEVSITSAHIDPDASYMAA 189 Query: 373 TGGGTSDRHIRIWNVCSGA--------CLSAVDAHSQV-CSILWSPHYKELISGHGFAQN 423 + +WN+ G + + AH++ +SP L + A Sbjct: 190 VNST---GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS--ADQ 244 Query: 424 QLVIWKYPTMAKVAEL--------KGHTSRVLSLTMSPDGATVASAAADETLRLWRCFEL 475 IW+ + + EL + + S D + +A++D RLW C E Sbjct: 245 TCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW-CVET 303 Query: 476 DPARRR 481 +R Sbjct: 304 GEIKRE 309 Score = 63.3 bits (152), Expect = 3e-10, Method: Composition-based stats. Identities = 19/109 (17%), Positives = 35/109 (32%) Query: 367 QSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLV 426 S+ + D +R W SG C V + L + +I+ G+ ++ Sbjct: 11 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMY 70 Query: 427 IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFEL 475 + G + S+ DG + + D T R+W Sbjct: 71 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSR 119 Score = 62.9 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 37/95 (38%), Gaps = 6/95 (6%) Query: 193 SSGNVLAVALDNSVYLWSASSGDILQLL------QMEQPGEYISSVAWIKEGNYLAVGTS 246 S + + D + +W S+ ++ L E ++ A+ + Y+ +S Sbjct: 233 DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASS 292 Query: 247 SAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYIL 281 +LW V+ + R H V L++N +L Sbjct: 293 DNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 327 Score = 36.7 bits (83), Expect = 0.022, Method: Composition-based stats. Identities = 11/68 (16%), Positives = 30/68 (44%), Gaps = 1/68 (1%) Query: 410 HYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRL 469 +I + + W+ + ++ S+V +L ++PD + +A+A + +R+ Sbjct: 11 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRM 69 Query: 470 WRCFELDP 477 + +P Sbjct: 70 YDLNSNNP 77 Score = 30.1 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 9/46 (19%), Positives = 18/46 (39%) Query: 450 TMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIH 495 T+ D +A+A D T+R W+ R + + + + Sbjct: 9 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP 54 >4PSX-B nrPDB Length = 401 Score = 119 bits (298), Expect = 3e-27, Method: Composition-based stats. Identities = 42/229 (18%), Positives = 91/229 (39%), Gaps = 12/229 (5%) Query: 277 NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNV 335 + I+++ + G + +E +TL H L ++ L SG +D+ V + Sbjct: 130 DPNIVATINGQGTTFLYS--RSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVAL 187 Query: 336 WPSAPGEGGWVPLQTFTQ-HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC-SGACL 393 W G P++T+ H + W + ++ G + D ++I +V + + Sbjct: 188 WEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLF--GTVSEDSLLKINDVRANNTTI 245 Query: 394 SAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPT-MAKVAELKGHTSRVLSLTMS 452 V ++ +S H L++ G + + ++ + + GH V +L S Sbjct: 246 DTVKCPQPFNTLAFSHHSSNLLAAAG-MDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFS 304 Query: 453 P--DGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR 499 DG V S+ +D L +W ++ + + + + ++H G R Sbjct: 305 THVDG-VVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHR 352 Score = 99.5 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 45/318 (14%), Positives = 115/318 (36%), Gaps = 27/318 (8%) Query: 97 KENQPENSQTPTKKEHQKAWALNLNGFDVEEAKI------LRLSGKPQNAPEGYQNRLKV 150 +EN + ++ KE + ++ + +R++ K ++ E + R Sbjct: 69 EENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMP 128 Query: 151 LYSQKATPGSSRKTCRYIPSLPDRILDAPEIRND-YYLNLVDWSSGNVLAVALDNSVYLW 209 + + T +++ Y L+ G +L+ + D++V LW Sbjct: 129 QDPNIVATINGQGTTFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALW 188 Query: 210 SASSG-DILQLLQM--EQPGEYISSVAWIKEGN-YLAVGTSSAEVQLWDVQQQKRLRNMT 265 SG D + ++ + + I+ W + + +++ DV+ + Sbjct: 189 EVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTV 248 Query: 266 SHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD-G 321 +L+++ S +L++ +++ +D+R + + +SGH V L ++ Sbjct: 249 KCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVD 308 Query: 322 RHLASGGNDNLVNVWPS----------APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVL 371 + S G+DN + +W +G + H+ +V P ++ Sbjct: 309 GVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLV 368 Query: 372 ATGGGTSDRHIRIWNVCS 389 A+ + +++W Sbjct: 369 ASAE--EENILQVWKCSH 384 Score = 96.4 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 62/281 (22%), Positives = 105/281 (37%), Gaps = 49/281 (17%) Query: 204 NSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQ----K 259 + +L+S S G + L+ + Y S + + +G L G+ V LW+V K Sbjct: 141 GTTFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKGRLL-SGSDDHTVALWEVGSGGDPTK 198 Query: 260 RLRNMTS-HSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGL 315 +R HS + W N + + S + +DVR + T+ Q L Sbjct: 199 PVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVK-CPQPFNTL 257 Query: 316 RW-APDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATG 374 + LA+ G D+ V ++ + PL + H+ AV + + V+ + Sbjct: 258 AFSHHSSNLLAAAGMDSYVYLYDLRNMK---EPLHHMSGHEDAVNNLEFSTHVDGVVVSS 314 Query: 375 GGTSDRHIRIWNVCS-GACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTM 433 G SD + +W++ GA + DA V ELI H Sbjct: 315 G--SDNRLMMWDLKQIGAEQTPDDAEDGV---------PELIMVHA-------------- 349 Query: 434 AKVAELKGHTSRVLSLTMSPDGATV-ASAAADETLRLWRCF 473 GH S V ++P + ASA + L++W+C Sbjct: 350 -------GHRSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 >5MWJ-A nrPDB Length = 337 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 48/262 (18%), Positives = 92/262 (35%), Gaps = 19/262 (7%) Query: 218 QLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ---QQKRLRNMT--SHSARVG 272 + + GE + +V ++ G V++WD+ + + + + + Sbjct: 43 RQINTLNHGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNKSPVSQLDCLNRDNYIR 101 Query: 273 SLSW--NSYILSSGSRSGHIHHHDVRVAEHHV-ATLSGHSQEVCGLRWAPDGRHLASGGN 329 S + L G + + D+ + A L+ + L +PD + S + Sbjct: 102 SCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCS 161 Query: 330 DNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS 389 D + VW ++ F H + + + G D +R W++ Sbjct: 162 DGNIAVWDLHN----QTLVRQFQGHTDGASCIDISNDGTKL---WTGGLDNTVRSWDLRE 214 Query: 390 GACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSL 449 G L D SQ+ S+ + P + L G + +++ P ++ H S VLSL Sbjct: 215 GRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHL---HESCVLSL 271 Query: 450 TMSPDGATVASAAADETLRLWR 471 + G S D L WR Sbjct: 272 KFAYCGKWFVSTGKDNLLNAWR 293 Score = 101 bits (252), Expect = 6e-22, Method: Composition-based stats. Identities = 41/251 (16%), Positives = 87/251 (34%), Gaps = 17/251 (6%) Query: 181 IRNDYYLNLVDWSSGN-VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGN 239 R++Y + G ++ +++ +W ++ ++ ++A + Sbjct: 95 NRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSK 154 Query: 240 YLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRV 297 S + +WD+ Q +R H+ + + L +G + D+R Sbjct: 155 VCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLRE 214 Query: 298 AEHHVATLSGH--SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQ 355 L H + ++ L + P G LA G + V V + + L H+ Sbjct: 215 GRQ----LQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHL-----HE 265 Query: 356 GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELI 415 V ++ + ++TG D + W GA + S V S S K ++ Sbjct: 266 SCVLSLKFAYCGKWFVSTG---KDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIV 322 Query: 416 SGHGFAQNQLV 426 +G G + + Sbjct: 323 TGSGDKKATVY 333 Score = 97.5 bits (241), Expect = 1e-20, Method: Composition-based stats. Identities = 38/187 (20%), Positives = 71/187 (37%), Gaps = 11/187 (5%) Query: 300 HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP-SAPGEGGWVPLQTFTQHQGAV 358 + TL+ H + VC + + RH+ +GG V VW S PG V + Sbjct: 43 RQINTLN-HGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNKSPVSQLDCLNRDNYI 100 Query: 359 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS---QVCSILWSPHYKELI 415 ++ P ++ G + + IW++ + + S ++ SP K Sbjct: 101 RSCKLLPDGCTLIVGGEAS---TLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCF 157 Query: 416 SGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFEL 475 S + + +W V + +GHT + +S DG + + D T+R W E Sbjct: 158 SC--CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREG 215 Query: 476 DPARRRE 482 ++ + Sbjct: 216 RQLQQHD 222 Score = 84.1 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 39/219 (17%), Positives = 83/219 (37%), Gaps = 15/219 (6%) Query: 171 LPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYIS 230 P + Y + S + D ++ +W + +++ Q G S Sbjct: 130 TPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDG--AS 187 Query: 231 SVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSL--SWNSYILSSGSRSG 288 + +G L G V+ WD+++ ++L+ ++++ SL L+ G S Sbjct: 188 CIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESS 246 Query: 289 HIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPL 348 ++ V + + L H V L++A G+ S G DNL+N W + G + Sbjct: 247 NVEVLHVNKPDKY--QLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSK 304 Query: 349 QTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 387 ++ +V + ++ G+ D+ ++ V Sbjct: 305 ES-----SSVLSCDISVDDKYIV---TGSGDKKATVYEV 335 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 32/155 (20%), Positives = 55/155 (35%), Gaps = 14/155 (9%) Query: 353 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS------GACLSAVDAHSQVCSIL 406 H V AV +V G G +++W++ + L ++ + + S Sbjct: 49 NHGEVVCAVTISNPTRHVYTGGKGC----VKVWDISHPGNKSPVSQLDCLNRDNYIRSCK 104 Query: 407 WSPHYKELISGHGFAQNQLVIWKY--PTMAKVAELKGHTSRVLSLTMSPDGATVASAAAD 464 P LI G + L IW PT AEL +L +SPD S +D Sbjct: 105 LLPDGCTLIVGGEAS--TLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSD 162 Query: 465 ETLRLWRCFELDPARRREREKASAAKSSLIHQGIR 499 + +W R+ + A+ + + G + Sbjct: 163 GNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTK 197 >5CXC-A nrPDB Length = 510 Score = 116 bits (291), Expect = 2e-26, Method: Composition-based stats. Identities = 43/298 (14%), Positives = 93/298 (31%), Gaps = 45/298 (15%) Query: 236 KEGNYLAVGTSSAEVQLWDVQQQ----KRLRNMTSHSARVGSLSW-NSYILSSGSRSGHI 290 + + +++W+ + H+A + + + S L+S + Sbjct: 156 PGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRTV 215 Query: 291 HHHDVRVAEHHVATLS------GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG 344 ++H L GH+ V L +H+ + D + W ++ Sbjct: 216 RVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASAP 275 Query: 345 WVPLQTFTQ--------------------------HQGAVKAVAWCPWQSNVLATGGGTS 378 H A + P V + + Sbjct: 276 EPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSA--SQ 333 Query: 379 DRHIRIWNVCSGACLSAVDAHSQVCSI--LWSPHYKELISGHGFAQNQLVIWKYPTM--- 433 D +R ++ +G +S + + S+ L + G + + + Sbjct: 334 DHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSAT 393 Query: 434 AKVAELKGHTSRVLSLTMSPDGAT-VASAAADETLRLWRCFELDPARRREREKASAAK 490 V L+GH ++V+SL+ SP+ + S + D T R+W + PA + E ++ Sbjct: 394 TSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSLGGVSE 451 Score = 66.0 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 47/236 (19%), Positives = 83/236 (35%), Gaps = 40/236 (16%) Query: 190 VDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYIS-------SVAWIKEGNYLA 242 VD S ++L + D ++ WSAS + PG ++S SV+ + G Sbjct: 248 VDGHSKHILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGL 307 Query: 243 ----------------------VGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS----- 275 + V+ D+ + + +T + + SLS Sbjct: 308 WSIHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTL-THPLLSLSALTRA 366 Query: 276 -WNSYILSSGSRSGHIHHHDVRVAEH--HVATLSGHSQEVCGLRWAPDGRH-LASGGNDN 331 S +L++G+ + HI D R + V TL GH+ +V L +P+ + L SG +D Sbjct: 367 GTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDG 426 Query: 332 LVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 387 VW + V + W S D ++++V Sbjct: 427 TCRVWDLRSVRPATKEEGSLGGVSEPVYVIERESWASKGKKKRPVAGDG-CKVFSV 481 Score = 44.0 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 14/104 (13%), Positives = 32/104 (30%), Gaps = 30/104 (28%) Query: 219 LLQMEQPGEYISSVAWIKEGNY-LAVGTSSAEVQLWDVQQ-------------------- 257 ++ + + S++ E Y L G+ ++WD++ Sbjct: 396 VMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSLGGVSEPVYV 455 Query: 258 ---------QKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHH 292 K+ R + +V S+ W+ + SG + Sbjct: 456 IERESWASKGKKKRPVAGDGCKVFSVVWDKLGIFSGGEDKKVQV 499 >5BJS-A nrPDB Length = 605 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 41/200 (20%), Positives = 82/200 (41%), Gaps = 26/200 (13%) Query: 210 SASSGDILQLLQMEQPGEYISSVAWIKE----GNYLAVGTSSAEVQLWDVQQQKRLRNMT 265 A+ +I+QL++ + +S W K+ L + + V++++V + K R + Sbjct: 117 DANPCEIIQLIRDDGNEANCASC-WSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLV 175 Query: 266 SHSARVGSLSW---NSYILSSGSRSGHIHHHDV-----RVAEHHVATLSGHSQEVCGLRW 317 H + L+ N YI++S S I + + + GHS ++ + + Sbjct: 176 GHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAF 235 Query: 318 APDGRHLASGGNDNLVNVW--PSAPGEGGWVPLQTFTQ-------HQGAVKAVAWCPWQS 368 +GR++ S G+D ++N+W P P E +P+ + H V VA+ Sbjct: 236 HDNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFYGD-- 293 Query: 369 NVLATGGGTSDRHIRIWNVC 388 L + I +W + Sbjct: 294 --LILSRACHEDTIVLWRIE 311 Score = 69.4 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 26/125 (20%), Positives = 44/125 (35%), Gaps = 9/125 (7%) Query: 362 AWC--PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHG 419 W P L G ++ +++++NV G + H + L + I Sbjct: 139 CWSKDPITDQPLLCIAG-NEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASA 197 Query: 420 FAQNQLVIWKY----PTMAKVAEL--KGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473 + IW V L +GH+ +LS+ +G V SA D+ + LW Sbjct: 198 SDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALP 257 Query: 474 ELDPA 478 E Sbjct: 258 EFPNE 262 Score = 60.9 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 18/86 (20%), Positives = 32/86 (37%), Gaps = 3/86 (3%) Query: 397 DAHSQVCSILWS--PHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPD 454 D + C+ WS P + + + + ++ L GH + L SP Sbjct: 130 DGNEANCASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPA 189 Query: 455 GAT-VASAAADETLRLWRCFELDPAR 479 +ASA+ D T+R+W + Sbjct: 190 NPYIIASASDDTTIRIWSLAPEHEKQ 215 Score = 58.6 bits (140), Expect = 6e-09, Method: Composition-based stats. Identities = 16/119 (13%), Positives = 39/119 (32%), Gaps = 18/119 (15%) Query: 197 VLAVALDNSVYLWSASSGD----ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 252 + + + D ++ +WS + + +L E + SVA+ G Y+ + L Sbjct: 194 IASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINL 253 Query: 253 WDVQQQKRLR-------------NMTSHSARVGSLSWNSYILSS-GSRSGHIHHHDVRV 297 W + + + H+ V +++ ++ S I + Sbjct: 254 WALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFYGDLILSRACHEDTIVLWRIEG 312 >5WLC-LU nrPDB Length = 489 Score = 114 bits (285), Expect = 8e-26, Method: Composition-based stats. Identities = 68/379 (17%), Positives = 131/379 (34%), Gaps = 61/379 (16%) Query: 137 PQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAP-------EIRNDYYLNL 189 P + + Q + + T + +R+ P R+ Y Sbjct: 15 PVKSTQESQMPRNLNPELHPFERAREYTKALNATKLERMFAKPFVGQLGYGHRDGVYAIA 74 Query: 190 VDWSSGNVLA-VALDNSVYLWSASSGDILQLLQMEQPGEYISSVAW-----------IKE 237 ++ S N LA + D + W+ S+ + + + ++ + +K Sbjct: 75 KNYGSLNKLATGSADGVIKYWNMST--REEFVSFKAHYGLVTGLCVTQPRFHDKKPDLKS 132 Query: 238 GNYLAVGTSSAEVQLWD-----------------VQQQKRLRNMTSHSA--RVGSLSWNS 278 N++ + V+LW ++ +R SA + S NS Sbjct: 133 QNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQGIDSHRENS 192 Query: 279 YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDG-RHLASGGNDNLVNVWP 337 ++G IH DV + V+ LS + + L++ + LAS G+DN + ++ Sbjct: 193 T-FATGGA--KIHLWDVNRLKP-VSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYD 248 Query: 338 SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAV 396 +QT A+ W P ++ D + +++ + L+ Sbjct: 249 LRTNSPTQKIVQTMRT-----NAICWNPMEA--FNFVTANEDHNAYYYDMRNLSRSLNVF 301 Query: 397 DAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSR---VLSLTMS 452 H S V + +SP E+++G + I+K HT R V + S Sbjct: 302 KDHVSAVMDVDFSPTGDEIVTGS--YDKSIRIYKTNHGHSREIY--HTKRMQHVFQVKYS 357 Query: 453 PDGATVASAAADETLRLWR 471 D + S + D +RLWR Sbjct: 358 MDSKYIISGSDDGNVRLWR 376 Score = 83.7 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 30/201 (14%), Positives = 64/201 (31%), Gaps = 35/201 (17%) Query: 307 GHSQEVCGLRWA-PDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA--- 362 GH V + LA+G D ++ W + E +F H G V + Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFV----SFKAHYGLVTGLCVTQ 120 Query: 363 --WC---PWQSNVLATGGGTSDRHIRIWNVCSGAC-----------------LSAVDAHS 400 + P + + D+ +++W++ + D S Sbjct: 121 PRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGES 180 Query: 401 QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVA 459 I +G ++ +W + V++L + SL + + +A Sbjct: 181 AFQGIDSHRENSTFATGGA----KIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILA 236 Query: 460 SAAADETLRLWRCFELDPARR 480 S +D ++ L+ P ++ Sbjct: 237 STGSDNSIVLYDLRTNSPTQK 257 Score = 73.7 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 30/177 (16%), Positives = 61/177 (34%), Gaps = 25/177 (14%) Query: 183 NDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY-L 241 N L + + + DNS+ L+ + Q + ++ W + Sbjct: 221 NITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIVQTMRTN---AICWNPMEAFNF 277 Query: 242 AVGTSSAEVQLWDVQQQKRLRN-MTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVA 298 +D++ R N H + V + ++ + +GS I + Sbjct: 278 VTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIY----- 332 Query: 299 EHHVATLSGHSQEVCG---------LRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV 346 T GHS+E+ ++++ D +++ SG +D V +W S E V Sbjct: 333 ----KTNHGHSREIYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLWRSKAWERSNV 385 Score = 45.2 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 17/88 (19%), Positives = 29/88 (32%), Gaps = 11/88 (12%) Query: 416 SGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMS--------PDGA---TVASAAAD 464 G A + W T + K H V L ++ PD + S + D Sbjct: 83 LATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFHDKKPDLKSQNFMLSCSDD 142 Query: 465 ETLRLWRCFELDPARRREREKASAAKSS 492 +T++LW D + + + S Sbjct: 143 KTVKLWSINVDDYSNKNSSDNDSVTNEE 170 Score = 33.2 bits (74), Expect = 0.28, Method: Composition-based stats. Identities = 7/40 (17%), Positives = 16/40 (40%), Gaps = 1/40 (2%) Query: 440 KGHTSRVLSLTMSPDG-ATVASAAADETLRLWRCFELDPA 478 GH V ++ + +A+ +AD ++ W + Sbjct: 64 YGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEF 103 >2AQ5-A nrPDB Length = 402 Score = 111 bits (277), Expect = 8e-25, Method: Composition-based stats. Identities = 45/242 (18%), Positives = 85/242 (35%), Gaps = 23/242 (9%) Query: 212 SSGDILQLLQME-QPGEYISSVAWIKEG-NYLAVGTSSAEVQLWDVQQQ-------KRLR 262 +G + + + + + +AW N +A G+ V +W++ + + Sbjct: 66 KTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVI 125 Query: 263 NMTSHSARVGSLSWNS---YILSSGSRSGHIHHHDVRVAEHHVATL--SGHSQEVCGLRW 317 + H+ RVG ++W+ +L S I DV V TL H + + W Sbjct: 126 TLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGA-AVLTLGPDVHPDTIYSVDW 184 Query: 318 APDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATG-GG 376 + DG + + D V V G + V AV + +L TG Sbjct: 185 SRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEG-TRPVHAVFVS--EGKILTTGFSR 241 Query: 377 TSDRHIRIWNVCSGAC---LSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTM 433 S+R + +W+ L +D S V + P + G + + ++ + Sbjct: 242 MSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLC-GKGDSSIRYFEITSE 300 Query: 434 AK 435 A Sbjct: 301 AP 302 Score = 111 bits (277), Expect = 8e-25, Method: Composition-based stats. Identities = 38/157 (24%), Positives = 70/157 (44%), Gaps = 23/157 (14%) Query: 353 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG-------ACLSAVDAHSQ-VCS 404 H V +AWCP NV+A+ G+ D + +W + G + ++ H++ V Sbjct: 79 GHTAPVLDIAWCPHNDNVIAS--GSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGI 136 Query: 405 ILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL--KGHTSRVLSLTMSPDGATVASAA 462 + W P + ++ G N +++W T A V L H + S+ S DGA + ++ Sbjct: 137 VAWHPTAQNVLLSAGC-DNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSC 195 Query: 463 ADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR 499 D+ +R+ ++P R+ A+ H+G R Sbjct: 196 RDKRVRV-----IEP-----RKGTVVAEKDRPHEGTR 222 Score = 81.4 bits (199), Expect = 8e-16, Method: Composition-based stats. Identities = 38/218 (17%), Positives = 76/218 (34%), Gaps = 23/218 (10%) Query: 190 VDWSSGN---VLAVALDNSVYLWSASSGDI-----LQLLQMEQPGEYISSVAWIKE-GNY 240 + W N + + + D +V +W G + ++ +E + + VAW N Sbjct: 87 IAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNV 146 Query: 241 LAVGTSSAEVQLWDVQQQKRLRNM--TSHSARVGSLSW--NSYILSSGSRSGHIHHHDVR 296 L + +WDV + + H + S+ W + ++ + R + + R Sbjct: 147 LLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPR 206 Query: 297 VAEHHVATLSGHSQ--EVCGLRWAPDGRHLASG---GNDNLVNVWPSAPGEGGWVPLQTF 351 H V + + +G+ L +G ++ V +W + E + Sbjct: 207 KGTVVAEKDRPHEGTRPVHAV-FVSEGKILTTGFSRMSERQVALWDTKHLEEPLSLQELD 265 Query: 352 TQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS 389 T V + P + V G G D IR + + S Sbjct: 266 T--SSGVLLPFFDPDTNIVYLCGKG--DSSIRYFEITS 299 Score = 58.6 bits (140), Expect = 6e-09, Method: Composition-based stats. Identities = 30/175 (17%), Positives = 64/175 (36%), Gaps = 12/175 (6%) Query: 189 LVDW---SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGT 245 +V W + +L+ DN + +W +G + L + + I SV W ++G + Sbjct: 136 IVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSC 195 Query: 246 SSAEVQLWDVQQQKRLR---NMTSHSARVGSLSWN-SYILSSG-SR--SGHIHHHDVRVA 298 V++ + ++ + + V ++ + IL++G SR + D + Sbjct: 196 RDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSEGKILTTGFSRMSERQVALWDTKHL 255 Query: 299 EHHVATLSG-HSQEVCGLRWAPDGRHLASGGN-DNLVNVWPSAPGEGGWVPLQTF 351 E ++ S V + PD + G D+ + + L F Sbjct: 256 EEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMF 310 >5K0Y-T nrPDB Length = 329 Score = 108 bits (269), Expect = 7e-24, Method: Composition-based stats. Identities = 40/317 (12%), Positives = 85/317 (26%), Gaps = 72/317 (22%) Query: 218 QLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS-- 275 + + ++ I+ + + +EG+ L V +W +RL H+ V + Sbjct: 2 RPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDAD 61 Query: 276 WNSYILSSGSRSGHIHHHDVRV---------------------------------AEHHV 302 W++ + +GS D Sbjct: 62 WDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCF 121 Query: 303 ATLSGHSQE------------------VCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG 344 + + W P G + +G +N + + GE Sbjct: 122 VSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEV- 180 Query: 345 WVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCS 404 L +H + + + + D ++++ + Sbjct: 181 ---LVNVKEHSRQINDIQLS---REMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPREL 234 Query: 405 ILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL------------KGHTSRVLSLTMS 452 SP+Y+ ++ G G + A KGH + S+ Sbjct: 235 AALSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFH 294 Query: 453 PDGATVASAAADETLRL 469 PDG + +S D +R+ Sbjct: 295 PDGKSYSSGGEDGYVRI 311 Score = 95.2 bits (235), Expect = 6e-20, Method: Composition-based stats. Identities = 37/232 (15%), Positives = 94/232 (40%), Gaps = 27/232 (11%) Query: 264 MTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDG 321 + H + + +N +L + ++ ++ V + T GH+ V + D Sbjct: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVW-YSVNGERLGTYMGHTGAVWCVDADWDT 64 Query: 322 RHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRH 381 +H+ +G DN +W G+ L+T AV+ + + N++ ++D+ Sbjct: 65 KHVLTGSADNSCRLWDCETGK-QLALLKT----NSAVRTCGFD-FGGNIIMF---STDKQ 115 Query: 382 ------IRIWNVCSGACLSAVD-------AHSQVCSILWSPHYKELISGHGFAQNQLVIW 428 + +++ + + + S++ S +W P + +I+GH +L + Sbjct: 116 MGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGH--ESGELNQY 173 Query: 429 KYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 + + +K H+ ++ + +S + +A+ D T +L+ L+ + Sbjct: 174 SAKSGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKT 225 Score = 78.3 bits (191), Expect = 7e-15, Method: Composition-based stats. Identities = 46/267 (17%), Positives = 93/267 (34%), Gaps = 36/267 (13%) Query: 191 DWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE- 249 DW + +VL + DNS LW +G L LL+ + + + GN + T Sbjct: 61 DWDTKHVLTGSADNSCRLWDCETGKQLALLKT---NSAVRTCGFDFGGNIIMFSTDKQMG 117 Query: 250 ----VQLWDVQ------QQKRLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRV 297 V +D++ + + + +++ S W + +G SG ++ + + Sbjct: 118 YQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKS 177 Query: 298 AEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGA 357 E V HS+++ ++ + + + DN ++ S E +TF Sbjct: 178 GEVLVNV-KEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQ----KTFR--TEP 230 Query: 358 VKAVAWCPWQSNVLATGGG--TSDRH----------IRIWNVCSGACLSAVDAH-SQVCS 404 + +A + GGG D R +++ V H + S Sbjct: 231 PRELAALSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINS 290 Query: 405 ILWSPHYKELISGHGFAQNQLVIWKYP 431 + + P K SG ++ + Sbjct: 291 VAFHPDGKSYSSGGEDGYVRIHYFDPQ 317 >4U1E-I nrPDB Length = 347 Score = 107 bits (268), Expect = 8e-24, Method: Composition-based stats. Identities = 43/324 (13%), Positives = 98/324 (30%), Gaps = 78/324 (24%) Query: 218 QLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN 277 + +++ ++ V + KEG+ L + + +W +RL + H+ + S+ + Sbjct: 2 KAIKLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVD 61 Query: 278 --SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVN- 334 + +GS I DV VAT V + ++P G + DN++ Sbjct: 62 CFTKYCVTGSADYSIKLWDVSNG-QCVATWKS-PVPVKRVEFSPCGNYFL-AILDNVMKN 118 Query: 335 -----VWPSAPGEGGWVPLQT-----------------------------FTQHQG---- 356 ++ + H+ Sbjct: 119 PGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKIS 178 Query: 357 -------------------AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVD 397 ++ + + P + + + + D + + +V + L + Sbjct: 179 KYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITS---SRDTNSFLVDVSTLQVLKKYE 235 Query: 398 AHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK------------GHTSR 445 + + + +P + +I G G + A GH Sbjct: 236 TDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGP 295 Query: 446 VLSLTMSPDGATVASAAADETLRL 469 + ++ +SP G + AS D +RL Sbjct: 296 LNTVAISPQGTSYASGGEDGFIRL 319 Score = 59.8 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 13/86 (15%), Positives = 30/86 (34%), Gaps = 3/86 (3%) Query: 396 VDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPD 454 + H + + ++ L S + +W ++ L GHT + S+ + Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCS--KDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCF 63 Query: 455 GATVASAAADETLRLWRCFELDPARR 480 + +AD +++LW Sbjct: 64 TKYCVTGSADYSIKLWDVSNGQCVAT 89 Score = 38.2 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 7/49 (14%), Positives = 18/49 (36%) Query: 438 ELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKA 486 +L GH + + + +G + S + D + +W + + Sbjct: 5 KLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTG 53 Score = 31.7 bits (70), Expect = 0.84, Method: Composition-based stats. Identities = 30/254 (11%), Positives = 75/254 (29%), Gaps = 40/254 (15%) Query: 62 KSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSK-ENQPENSQTPTKKEHQKAWALNL 120 KS V+ P G+ ++ S + + E + E + Sbjct: 91 KSPVPVKRVEFSPCGNYFLAILDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITH 150 Query: 121 NGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPE 180 G D GK A G+++ Y +D+ + Sbjct: 151 EGLDAATVAGWSTKGKYIIA--GHKDGKISKYDVSNN---------------YEYVDSID 193 Query: 181 IRNDYYLNLVDWSSGN--VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEG 238 + ++ + +S + + D + +L S+ LQ+L+ + +++ Sbjct: 194 LHEK-SISDMQFSPDLTYFITSSRDTNSFLVDVST---LQVLKKYETDCPLNTAVITPLK 249 Query: 239 NYLAVGT----SSAE----------VQLWDVQQQKRLRNMTSHSARVGSLSWNSY--ILS 282 ++ +G + + ++ + + H + +++ + + Sbjct: 250 EFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLNTVAISPQGTSYA 309 Query: 283 SGSRSGHIHHHDVR 296 SG G I H Sbjct: 310 SGGEDGFIRLHHFE 323 >5A9Q-7 nrPDB Length = 360 Score = 107 bits (268), Expect = 9e-24, Method: Composition-based stats. Identities = 54/335 (16%), Positives = 110/335 (32%), Gaps = 65/335 (19%) Query: 178 APEIRNDYYLNLVDWSSGNVLAVALDNSVYLWS-ASSGDILQLLQMEQPGEYISSVAWIK 236 A + ++ + D+ + + D SV +W + SGD + + V W Sbjct: 8 AADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAH 67 Query: 237 E--GNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSA------------RVGSLSWNSY--- 279 G LA + +W+ + + S V + + Sbjct: 68 PEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMG 127 Query: 280 -ILSSGSRSGHIHHHD----VRVAEHHVATLSGHSQEVCGLRWAPDGRH-----LASGGN 329 +L++ S G + ++ + +++ + + W P +A G + Sbjct: 128 LMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSD 187 Query: 330 DNL------VNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW-QSNVLATGGGTSDRHI 382 D+ V ++ + +T V +A+ P + T D + Sbjct: 188 DSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD--V 245 Query: 383 RIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGH 442 RI+ + P KEL S G + ++ I VA+ H Sbjct: 246 RIFTLK--------------------PVRKELTSSGGPTKFEIHI--------VAQFDNH 277 Query: 443 TSRVLSLTMSPDGATVASAAADETLRLWRCFELDP 477 S+V ++ + G +AS+ D +RLW+ +D Sbjct: 278 NSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDN 312 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 22/157 (14%), Positives = 56/157 (35%), Gaps = 21/157 (13%) Query: 354 HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWN---VCSGACLSAVDAHSQ-VCSILWSP 409 H+ + V++ + +SD+ +++W+ C ++ HS V + W+ Sbjct: 11 HKDLIHDVSFDFHGRRM---ATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAH 67 Query: 410 HYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRV------------LSLTMSPD--G 455 + +W+ +L+G + V + +P G Sbjct: 68 PEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMG 127 Query: 456 ATVASAAADETLRLWRCFELDPARRREREKASAAKSS 492 +A+ +AD +R++ ++ + + + K S Sbjct: 128 LMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLS 164 Score = 36.7 bits (83), Expect = 0.026, Method: Composition-based stats. Identities = 13/64 (20%), Positives = 22/64 (34%), Gaps = 3/64 (4%) Query: 215 DILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV---QQQKRLRNMTSHSARV 271 +I + Q + + V+W G LA V+LW K + + + V Sbjct: 267 EIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPV 326 Query: 272 GSLS 275 S Sbjct: 327 NGSS 330 >5OQL-X nrPDB Length = 630 Score = 106 bits (264), Expect = 3e-23, Method: Composition-based stats. Identities = 48/272 (17%), Positives = 89/272 (32%), Gaps = 24/272 (8%) Query: 215 DILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSL 274 + + V ++G ++ G + + +++ K ++ T H V L Sbjct: 235 RKANDKTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGL 294 Query: 275 SW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNL 332 ++ + L S S+ + + +V TL GH E+ + R ++ G D Sbjct: 295 AFRRGTNQLYSCSKDRTVKVWSL-DELAYVETLFGHQDEILDIDALGQERCVSVGARDRT 353 Query: 333 VNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGAC 392 W P E V K P A G+ DR I + Sbjct: 354 ARYWKV-PEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDD----- 407 Query: 393 LSAVDAHSQVCSILWSPHYK---ELISGHGFAQNQLVIWKY-------PTMAKVAELKGH 442 V LWS K +I+ + + + Y P++ + +G Sbjct: 408 -MFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRG- 465 Query: 443 TSRVLSLTMSPDGATVASAAADETLRLWRCFE 474 + +L P + S + D +R+WR E Sbjct: 466 ---ITALRTLPYSDLIFSGSWDGCIRVWRLSE 494 Score = 99.5 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 37/210 (17%), Positives = 74/210 (35%), Gaps = 32/210 (15%) Query: 303 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 T GH + ++ + DG+ + +GG D + V+ +A P++ FTQH+ AV +A Sbjct: 240 KTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAAD----LKPIKAFTQHRDAVTGLA 295 Query: 363 WCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQ 422 + + + + + DR +++W++ A + + H + +E G Sbjct: 296 FRRGTNQLYSC---SKDRTVKVWSLDELAYVETLFGHQDEI-LDIDALGQERCVSVGARD 351 Query: 423 NQLVIWKYPTMAKV---------------AELK--------GHTSRVLSLTMSPDGATVA 459 WK P +++ +L H + + M D Sbjct: 352 RTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMI-DDDMFV 410 Query: 460 SAAADETLRLWRCFELDPARRREREKASAA 489 + + + L LW P R Sbjct: 411 TGSDNGDLALWSIQRKKPLHVIARAHGLEP 440 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 23/223 (10%), Positives = 63/223 (28%), Gaps = 52/223 (23%) Query: 179 PEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEG 238 + R+ + + + + D +V +WS ++ + + + I + + + Sbjct: 285 TQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSL--DELAYVETLFGHQDEILDIDALGQE 342 Query: 239 NYLAVGTSSAEVQLWDV---------------QQQKRLRNM--------TSHSARVGSLS 275 ++VG + W V + + +H + ++ Sbjct: 343 RCVSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVA 402 Query: 276 -WNSYILSSGSRSGHIHHHDVRVAEHHVATLSGH-------------------------- 308 + + +GS +G + ++ + H Sbjct: 403 MIDDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQ 462 Query: 309 SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTF 351 + + LR P + SG D + VW + + + Sbjct: 463 PRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDKRKLEAVGIL 505 Score = 60.6 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 15/103 (14%), Positives = 33/103 (32%), Gaps = 1/103 (0%) Query: 394 SAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP 453 H + ++ + + + G A +LV++ + + H V L Sbjct: 240 KTYQGHLKAPLVVKASQDGKFVV-TGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFRR 298 Query: 454 DGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQ 496 + S + D T+++W EL + + Q Sbjct: 299 GTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQ 341 >5WYJ-BE nrPDB Length = 939 Score = 105 bits (262), Expect = 4e-23, Method: Composition-based stats. Identities = 36/240 (15%), Positives = 87/240 (36%), Gaps = 13/240 (5%) Query: 195 GNVLAVALDNSV-YLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW 253 N++ D W + + + ++ SVA + GN+ +G+S+ + ++ Sbjct: 428 ENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIY 487 Query: 254 DVQQQKRLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQE 311 ++Q + H V +S + + S G + +D + + L Sbjct: 488 NMQSGILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTL-LGKLKL-DAP 545 Query: 312 VCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVL 371 + + + A +D + V + ++ H + A + P ++ Sbjct: 546 ITAMVYHRSSDLFALALDDLSIVVIDAVT----QRVVRQLWGHSNRITAFDFSPEGRWIV 601 Query: 372 ATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYP 431 + + D IR W++ +G C+ + + ++ +SP+ L + H + IW Sbjct: 602 S---ASLDSTIRTWDLPTGGCIDGIIVDNVATNVKFSPNGDLLATTHVTGNG-ICIWTNR 657 Score = 104 bits (258), Expect = 1e-22, Method: Composition-based stats. Identities = 40/303 (13%), Positives = 105/303 (34%), Gaps = 39/303 (12%) Query: 182 RNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYL 241 + Y+ D S +L+ + D S++ +S Q + + ++G + Sbjct: 351 QPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQRLHKK--------QDGGRV 402 Query: 242 AVGTSSAE------VQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDV 295 T ++ + + + + + +T+H + +W+ R+ + Sbjct: 403 GGSTIKSKFPEIVALAIENARIGEWENIITAHKDEKFARTWDM-------RNKRVGRWTF 455 Query: 296 RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQ 355 + V + + G G ++ + ++ G + + + H+ Sbjct: 456 DTTD---------DGFVKSVAMSQCGNFGFIGSSNGSITIYNMQSG----ILRKKYKLHK 502 Query: 356 GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELI 415 AV ++ +++ G D + ++ L + + + ++++ Sbjct: 503 RAVTGISLDGMNRKMVSCG---LDGIVGFYDFNKSTLLGKLKLDAPITAMVYHRSSDLFA 559 Query: 416 SGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFEL 475 +V+ T V +L GH++R+ + SP+G + SA+ D T+R W Sbjct: 560 LA--LDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTG 617 Query: 476 DPA 478 Sbjct: 618 GCI 620 Score = 52.9 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 20/114 (17%), Positives = 46/114 (40%), Gaps = 4/114 (3%) Query: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 252 SS D S+ + A + +++ Q+ I++ + EG ++ + + ++ Sbjct: 554 SSDLFALALDDLSIVVIDAVTQRVVR--QLWGHSNRITAFDFSPEGRWIVSASLDSTIRT 611 Query: 253 WDVQQQKRLR-NMTSHSARVGSLSWNSYILSSGSRSGH-IHHHDVRVAEHHVAT 304 WD+ + + + A S N +L++ +G+ I R V+T Sbjct: 612 WDLPTGGCIDGIIVDNVATNVKFSPNGDLLATTHVTGNGICIWTNRAQFKTVST 665 Score = 42.1 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 35/239 (14%), Positives = 89/239 (37%), Gaps = 24/239 (10%) Query: 238 GNYLAVGTSSAEVQLWDVQQQKRLRNMTSHS-ARVGSLSWNSYILSSGSRSGHIHHHDVR 296 + V Q++D L + + + +LS + + + + + + R Sbjct: 46 STFYIVTCVGKTFQIYDANTLHLLFVSEKETPSSIVALSAHFHYVY-AAYENKVGIYK-R 103 Query: 297 VAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGW-------VPLQ 349 E H+ L V L G +L + +DN + ++ + + + + + Sbjct: 104 GIEEHLLELE-TDANVEHLCIF--GDYLCASTDDNSIFIYKKSDPQDKYPSEFYTKLTVT 160 Query: 350 TFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV-DAHSQVCSILWS 408 G + ++ N L + ++ ++NV +G + + Q+ + + Sbjct: 161 EIQG--GEIVSLQHLATYLNKLTVVTKS---NVLLFNVRTGKLVFTSNEFPDQITTAEPA 215 Query: 409 PHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA---TVASAAAD 464 P I G +++++ ++ +K SR+ SL+ DG+ +V +++ D Sbjct: 216 PVLD--IIALGTVTGEVIMFNMRKGKRIRTIKIPQSRISSLSFRTDGSSHLSVGTSSGD 272 >4E5Z-B nrPDB Length = 436 Score = 101 bits (252), Expect = 7e-22, Method: Composition-based stats. Identities = 56/320 (17%), Positives = 108/320 (33%), Gaps = 36/320 (11%) Query: 178 APEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK- 236 AP R L V + + LW+ D ++ G I+ + + Sbjct: 116 APFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPL 175 Query: 237 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVG------SLSWNSYILSSGSRSGHI 290 N + +L D + LR S S + +S +S ++ +G G++ Sbjct: 176 NTNQFYASSMEGTTRLQDF-KGNILRVFAS-SDTINIWFCSLDVSASSRMVVTGDNVGNV 233 Query: 291 HHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQ 349 ++ + L H ++V + P A+ D V +W G L Sbjct: 234 ILLNMDG--KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLY 291 Query: 350 TFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV-------DAHSQV 402 + H+ V A + P + +L T + IR+++ C + H Sbjct: 292 SL-PHRHPVNAACFSPDGARLLTTDQKS---EIRVYSASQWDCPLGLIPHPHRHFQHLTP 347 Query: 403 CSILWSPHYKELI----------SGHGFAQNQLVIWKYPTMAKVAELKG-HTSRVLSLT- 450 W P Y ++ S + + ++ + + +L +S + SL Sbjct: 348 IKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNE 407 Query: 451 MSPDGATVASAAADETLRLW 470 +P G T+AS A + +W Sbjct: 408 FNPMGDTLAS-AMGYHILIW 426 Score = 88.7 bits (218), Expect = 5e-18, Method: Composition-based stats. Identities = 49/267 (18%), Positives = 100/267 (37%), Gaps = 27/267 (10%) Query: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGE-YISSVAWIKEGNYLAVGTSSAEVQ 251 ++ A +++ + L G+IL++ + S+ + G + V Sbjct: 176 NTNQFYASSMEGTTRLQDFK-GNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVI 234 Query: 252 LWDVQQQKRLRNMTSHSARVGSLSWNS---YILSSGSRSGHIHHHDVRVAEHHVATLSG- 307 L ++ K L N+ H +V ++ N + L++ S + D+R + L Sbjct: 235 LLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL 293 Query: 308 -HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPL---QTFTQHQGAVKAVAW 363 H V ++PDG L + + + V+ ++ + + QH +KA AW Sbjct: 294 PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA-AW 352 Query: 364 CPWQSNVLA---------TGGGTSDRHIRIWNVCSGACL-SAVDAHSQVCSIL--WSPHY 411 P + ++ + R I +++ SG + D S S L ++P Sbjct: 353 HPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMG 412 Query: 412 KELISGHGFAQNQLVIWKYPTMAKVAE 438 L S G+ ++IW A+ + Sbjct: 413 DTLASAMGY---HILIWSEQEEARTRK 436 Score = 65.6 bits (158), Expect = 5e-11, Method: Composition-based stats. Identities = 34/223 (15%), Positives = 71/223 (31%), Gaps = 20/223 (8%) Query: 270 RVGSLSWNSYI---LSSGSRSGHIHHHDVRVAEHHVATL-SGHSQEVCGLRWAP-DGRHL 324 R SL+W+ ++ GS+ G I + + + G + GL++ P + Sbjct: 121 RATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQF 180 Query: 325 ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRI 384 + + + L+ F + +C + + T D + Sbjct: 181 YASSMEGTTRLQDF-----KGNILRVFA--SSDTINIWFCSLDVSASSRMVVTGDNVGNV 233 Query: 385 WNVC-SGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYP----TMAKVAE 438 + G L + H + V + +P + + IW + + Sbjct: 234 ILLNMDGKELWNLRMHKKKVTHVALNPCCDWFL-ATASVDQTVKIWDLRQVRGKASFLYS 292 Query: 439 LKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRR 481 L H V + SPDGA + + +R++ + D Sbjct: 293 LP-HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGL 334 >5M89-A nrPDB Length = 329 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 48/224 (21%), Positives = 83/224 (37%), Gaps = 18/224 (8%) Query: 242 AVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHH 301 AVG ++ ++ V K R + V + W + G+ G + +D A Sbjct: 67 AVGGLDGKLDIYSVVANKVERTLDI-GEPVTATEWTGTKVVIGTAKGWVKVYD---AGRE 122 Query: 302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 361 AT H+ V GL P GR LAS G D + GE A+ Sbjct: 123 SATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVARGYA-----DAALTTC 177 Query: 362 AWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFA 421 A+ P + GT HI +++ + + + + ++ +S + + G Sbjct: 178 AFHPDGN---LFAAGTQTGHILVFHTTTLEQAESFPLGTPIQALAFSENGFWF-AATGKG 233 Query: 422 QNQLVIWKYPT---MAKVAELKGHTSRVLSLTMSPDGATVASAA 462 + + I+ A V EL+ T VLS++ G +A+ Sbjct: 234 TSSVTIFDLRKSGAAAAVKELQ--TGEVLSISWDYTGQYLATGG 275 Score = 65.2 bits (157), Expect = 6e-11, Method: Composition-based stats. Identities = 38/235 (16%), Positives = 89/235 (37%), Gaps = 15/235 (6%) Query: 187 LNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTS 246 + +W+ V+ V ++ A + + ++ +A G LA Sbjct: 95 VTATEWTGTKVVIGTAKGWVKVYDAG----RESATFQTHAGPVTGLAVHPGGRILASVGV 150 Query: 247 SAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVAT 304 +D++ +R+ + A + + +++ + ++G+++GHI E + Sbjct: 151 DKSFVFYDLETGERVARGYA-DAALTTCAFHPDGNLFAAGTQTGHILVFHTTTLEQAESF 209 Query: 305 LSGHSQEVCGLRWAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAW 363 G + L ++ +G A+G + V ++ G ++ G V +++W Sbjct: 210 PLGT--PIQALAFSENGFWFAATGKGTSSVTIFDLR-KSGAAAAVKELQ--TGEVLSISW 264 Query: 364 CPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGH 418 + LATGGGT ++++ + + V V + W K L+ Sbjct: 265 D-YTGQYLATGGGTG-VTVQMYTKATKSWSEPVRLGMPVVGVKWGGEAKRLVVVS 317 Score = 52.9 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 19/107 (17%), Positives = 40/107 (37%), Gaps = 6/107 (5%) Query: 374 GGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTM 433 G D + I++V + +D V + W +++ G A+ + ++ Sbjct: 67 AVGGLDGKLDIYSVVANKVERTLDIGEPVTATEW--TGTKVVIGT--AKGWVKVYDA--G 120 Query: 434 AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 + A + H V L + P G +AS D++ + + R Sbjct: 121 RESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVAR 167 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 25/163 (15%), Positives = 54/163 (33%), Gaps = 18/163 (11%) Query: 320 DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSD 379 + A GG D ++++ + V A W + GT+ Sbjct: 62 ENECAAVGGLDGKLDIYSVVANKVERTLD---IGE--PVTATEWTGTK-----VVIGTAK 111 Query: 380 RHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAE 438 +++++ +G + H+ V + P + I V + T +VA Sbjct: 112 GWVKVYD--AGRESATFQTHAGPVTGLAVHPGGR--ILASVGVDKSFVFYDLETGERVA- 166 Query: 439 LKGHTSR-VLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 +G+ + + PDG A+ + ++ L+ A Sbjct: 167 -RGYADAALTTCAFHPDGNLFAAGTQTGHILVFHTTTLEQAES 208 >5N4A-A nrPDB Length = 771 Score = 100 bits (248), Expect = 2e-21, Method: Composition-based stats. Identities = 52/223 (23%), Positives = 84/223 (37%), Gaps = 21/223 (9%) Query: 267 HSARVGSLSWNSY-ILSSGSRSGHIHHHDV-RVAEHHVATLSG-----HSQEVCGLRWAP 319 HS ++ WN + L + S IH ++ E V+TL H V + Sbjct: 13 HSELTAAVGWNVWNELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKTQA 72 Query: 320 DG-RHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTS 378 G A D V + ++ H+GA ++ W + LAT G Sbjct: 73 GGTDVFAVACTDGSVKI-----LSRTGRVEKSIEGHKGACISLRWS-YDGTALATAG--E 124 Query: 379 DRHIRIWNVCSGACLSAV-DAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVA 437 D ++IW+ +G S + A S V SI+W+ +L G + +VI + AK Sbjct: 125 DGSVKIWS-RNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTG---SNVVIKSLSSNAKQN 180 Query: 438 ELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 K H VL + SP + + D ++W F + Sbjct: 181 AWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWDSFGRLLFQS 223 Score = 88.3 bits (217), Expect = 7e-18, Method: Composition-based stats. Identities = 48/256 (18%), Positives = 90/256 (35%), Gaps = 27/256 (10%) Query: 225 PGEYISSVAWIKEGNYLAVGTSSAEVQLWDV--QQQKRLRNMTS-----HSARVGSLSW- 276 E ++V W L + + W++ + ++++ + + H V S Sbjct: 13 HSELTAAVGWNVWNE-LFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKTQ 71 Query: 277 --NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVN 334 + + + G + + ++ GH LRW+ DG LA+ G D V Sbjct: 72 AGGTDVFAVACTDGSVKI--LSRTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVK 129 Query: 335 VWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS 394 +W + T Q V ++ W + G ++ I ++ S A + Sbjct: 130 IW-----SRNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGS----NVVIKSLSSNAKQN 180 Query: 395 AVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP 453 A AH V + WSP +I+ G + +W + + V S+ +P Sbjct: 181 AWKAHDGVVLKVDWSPINHLIIT--GGEDCKYKVWD-SFGRLLFQSGLFDYPVTSVAWAP 237 Query: 454 DGATVASAAADETLRL 469 G A TL+L Sbjct: 238 SGELFAVGGF-NTLQL 252 Score = 86.0 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 43/225 (19%), Positives = 79/225 (35%), Gaps = 21/225 (9%) Query: 196 NVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWD 254 +V AVA D SV + S +G + + + E S+ W +G LA V++W Sbjct: 76 DVFAVACTDGSVKILS-RTGRVEKSI--EGHKGACISLRWSYDGTALATAGEDGSVKIWS 132 Query: 255 VQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQE 311 + + + V S+ W + + I ++ H Sbjct: 133 -RNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIKSLSSNAKQNA---WKAHDGV 188 Query: 312 VCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVL 371 V + W+P + +GG D VW S L + V +VAW P + Sbjct: 189 VLKVDWSPINHLIITGGEDCKYKVWDSFGRLLFQSGLFDY-----PVTSVAWAP-SGELF 242 Query: 372 ATGGGTSDRHIRIWNVCSGACLSA-VDAHSQVCSILWSPHYKELI 415 A GG +++ + A ++ + ++ W+ +L Sbjct: 243 AVGGF---NTLQLCDRMGWAYSKIHLNDTGSIMTLSWTADSTQLA 284 Score = 70.2 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 35/185 (18%), Positives = 65/185 (35%), Gaps = 15/185 (8%) Query: 190 VDWSSG--NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247 + WS + D SV +WS + G + L Q + S+ W + + L T S Sbjct: 110 LRWSYDGTALATAGEDGSVKIWSRN-GMLRSTLA--QADSPVYSIVWAYDCDQLCYCTGS 166 Query: 248 AEVQLWDVQQQKRLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATL 305 V + + + +H V + W+ +++ +G D + L Sbjct: 167 NVV-IKSLSSNAKQNAWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWDSFGRLLFQSGL 225 Query: 306 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 365 V + WAP G A GG N + + GW + G++ ++W Sbjct: 226 F--DYPVTSVAWAPSGELFAVGGF-NTLQLCD----RMGWAYSKIHLNDTGSIMTLSWTA 278 Query: 366 WQSNV 370 + + Sbjct: 279 DSTQL 283 Score = 55.6 bits (132), Expect = 5e-08, Method: Composition-based stats. Identities = 25/97 (25%), Positives = 42/97 (43%), Gaps = 8/97 (8%) Query: 190 VDWS--SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247 VDWS + ++ D +W + G + L Q ++SVAW G AVG + Sbjct: 192 VDWSPINHLIITGGEDCKYKVWDSF-GRL--LFQSGLFDYPVTSVAWAPSGELFAVGGFN 248 Query: 248 AEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILS 282 +QL D + + + + +LSW +S L+ Sbjct: 249 -TLQLCDRMGWAYSKIHLNDTGSIMTLSWTADSTQLA 284 >4J0X-A nrPDB Length = 451 Score = 100 bits (248), Expect = 2e-21, Method: Composition-based stats. Identities = 43/293 (14%), Positives = 90/293 (30%), Gaps = 43/293 (14%) Query: 213 SGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNM--TSHSAR 270 + E + I +VA +G Y+ G ++ +W + ++ + Sbjct: 101 TSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGE 160 Query: 271 VGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGG 328 V SL++ NS L + I + + + L GH V + R + G Sbjct: 161 VLSLAFRKNSDQLYASCADFKIRTYSINQFSQ-LEILYGHHDIVEDISALAMERCVTVGA 219 Query: 329 NDNLVNVWPSAPGE--------------GGWVPLQTFTQHQGAVKA-------VAWCPWQ 367 D +W W+ G VK + +C Sbjct: 220 RDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGS 279 Query: 368 SNVLATG------GGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFA 421 +V++ G+ + +I +W++ + IL P + ++ G Sbjct: 280 IDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFT---ERIAHGILPEPSFNDI---SGET 333 Query: 422 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474 +L + + + SL P S + +L++W+ + Sbjct: 334 DEELRKRQLQGKKLLQPF-----WITSLYAIPYSNVFISGSWSGSLKVWKISD 381 Score = 78.7 bits (192), Expect = 6e-15, Method: Composition-based stats. Identities = 35/229 (15%), Positives = 76/229 (33%), Gaps = 40/229 (17%) Query: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 360 + T GH E+ + +PDG+++ +GG D + VW + V + +G V + Sbjct: 106 YENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVW--STESLSPVKVIPTKDRRGEVLS 163 Query: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGF 420 +A+ + A+ +D IR +++ + L + H + + + + ++ G Sbjct: 164 LAFRKNSDQLYAS---CADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTV-GA 219 Query: 421 AQNQLVIWKYPTMAKV--------AEL----------KGHTSRVLSLTMSP--------- 453 ++WK P ++ +L +G V S Sbjct: 220 RDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGS 279 Query: 454 -------DGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIH 495 D + + + + LW + P + S Sbjct: 280 IDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFND 328 Score = 35.5 bits (80), Expect = 0.053, Method: Composition-based stats. Identities = 15/119 (12%), Positives = 39/119 (32%), Gaps = 30/119 (25%) Query: 196 NVLAVALDNSVYLWSA--------------------------SSGDILQLLQMEQPGE-- 227 + + + + ++ LWS + + L+ Q++ Sbjct: 290 HFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKRQLQGKKLLQ 349 Query: 228 --YISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSG 284 +I+S+ I N G+ S +++W + R + + + ++ SG Sbjct: 350 PFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESG 408 Score = 30.5 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 17/121 (14%), Positives = 40/121 (33%), Gaps = 6/121 (4%) Query: 122 GFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEI 181 G D + L+ K E + + S G + + R ++L I Sbjct: 294 GSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKRQLQGKKLLQPFWI 353 Query: 182 RNDYYLNLVDWSSGNVLAVALDNSVYLWSASSG--DILQLLQMEQPGEYISSVAWIKEGN 239 + Y + S ++ + S+ +W S L ++ ++ + ++ G Sbjct: 354 TSLYAIPY----SNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGK 409 Query: 240 Y 240 + Sbjct: 410 H 410 >5WLC-SG nrPDB Length = 573 Score = 99.5 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 43/293 (14%), Positives = 90/293 (30%), Gaps = 43/293 (14%) Query: 213 SGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNM--TSHSAR 270 + E + I +VA +G Y+ G ++ +W + ++ + Sbjct: 223 TSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGE 282 Query: 271 VGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGG 328 V SL++ NS L + I + + + L GH V + R + G Sbjct: 283 VLSLAFRKNSDQLYASCADFKIRTYSINQFSQ-LEILYGHHDIVEDISALAMERCVTVGA 341 Query: 329 NDNLVNVWPSAPGE--------------GGWVPLQTFTQHQGAVKA-------VAWCPWQ 367 D +W W+ G VK + +C Sbjct: 342 RDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGS 401 Query: 368 SNVLATG------GGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFA 421 +V++ G+ + +I +W++ + IL P + ++ G Sbjct: 402 IDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFT---ERIAHGILPEPSFNDI---SGET 455 Query: 422 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474 +L + + + SL P S + +L++W+ + Sbjct: 456 DEELRKRQLQGKKLLQPF-----WITSLYAIPYSNVFISGSWSGSLKVWKISD 503 Score = 77.9 bits (190), Expect = 9e-15, Method: Composition-based stats. Identities = 35/229 (15%), Positives = 76/229 (33%), Gaps = 40/229 (17%) Query: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 360 + T GH E+ + +PDG+++ +GG D + VW + V + +G V + Sbjct: 228 YENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVW--STESLSPVKVIPTKDRRGEVLS 285 Query: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGF 420 +A+ + A+ +D IR +++ + L + H + + + + ++ G Sbjct: 286 LAFRKNSDQLYAS---CADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTV-GA 341 Query: 421 AQNQLVIWKYPTMAKV--------AEL----------KGHTSRVLSLTMSP--------- 453 ++WK P ++ +L +G V S Sbjct: 342 RDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGS 401 Query: 454 -------DGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIH 495 D + + + + LW + P + S Sbjct: 402 IDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFND 450 Score = 35.1 bits (79), Expect = 0.067, Method: Composition-based stats. Identities = 15/119 (12%), Positives = 39/119 (32%), Gaps = 30/119 (25%) Query: 196 NVLAVALDNSVYLWSA--------------------------SSGDILQLLQMEQPGE-- 227 + + + + ++ LWS + + L+ Q++ Sbjct: 412 HFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKRQLQGKKLLQ 471 Query: 228 --YISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSG 284 +I+S+ I N G+ S +++W + R + + + ++ SG Sbjct: 472 PFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESG 530 Score = 30.1 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 17/121 (14%), Positives = 40/121 (33%), Gaps = 6/121 (4%) Query: 122 GFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEI 181 G D + L+ K E + + S G + + R ++L I Sbjct: 416 GSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKRQLQGKKLLQPFWI 475 Query: 182 RNDYYLNLVDWSSGNVLAVALDNSVYLWSASSG--DILQLLQMEQPGEYISSVAWIKEGN 239 + Y + S ++ + S+ +W S L ++ ++ + ++ G Sbjct: 476 TSLYAIPY----SNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGK 531 Query: 240 Y 240 + Sbjct: 532 H 532 >4G56-B nrPDB Length = 357 Score = 99.1 bits (245), Expect = 4e-21, Method: Composition-based stats. Identities = 49/281 (17%), Positives = 100/281 (35%), Gaps = 21/281 (7%) Query: 170 SLPDRILDAPEIRNDYYLNLVDW-SSGNVLAVALDNSVYLWSASSGDILQLLQME--QPG 226 P+ L ++ + + V W S +L + +V LW + L + + + Sbjct: 80 GAPNESLCTAGVQTEAGVTDVAWVSEKGILVASDSGAVELWEILEKESLLVNKFAKYEHD 139 Query: 227 EYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS---YILSS 283 + + +++ +G G V++WD+ Q+ L++ +HS+ V ++ I S Sbjct: 140 DIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLS 199 Query: 284 GSRSGHIHHHDVRVAEHHVAT-LSGHSQEVCGLRWAPD-GRHLASG---GNDNLVNVWPS 338 G I D R + + W P+ A G GN +LVN+ Sbjct: 200 CGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNP 259 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 + V H + +A+ S LA+ + D + + + + Sbjct: 260 DSAQTSAV-------HSQNITGLAYSYHSSPFLAS--ISEDCTVAVLDADFSEVFRDLSH 310 Query: 399 HSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL 439 V + WSP + G ++++ P+ + L Sbjct: 311 RDFVTGVAWSPLDHSKFTTVG-WDHKVLHHHLPSEGRTENL 350 Score = 98.7 bits (244), Expect = 5e-21, Method: Composition-based stats. Identities = 47/248 (18%), Positives = 90/248 (36%), Gaps = 17/248 (6%) Query: 229 ISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRN----MTSHSARVGSLSW--NSYILS 282 ++ VAW+ E L V + S V+LW++ +++ L H V +LS + Sbjct: 97 VTDVAWVSEKGIL-VASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGTQAV 155 Query: 283 SGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPG 341 SG + + D+ + + + + HS EV + P S G D + +W + Sbjct: 156 SGGKDFSVKVWDL-SQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTR-- 212 Query: 342 EGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ 401 + F +V W P + + A G T ++ + N+ + HSQ Sbjct: 213 KPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDET--GNVSLVNIKNPDSAQTSAVHSQ 270 Query: 402 -VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP-DGATVA 459 + + +S H + + + +L H V + SP D + Sbjct: 271 NITGLAYSYHSSPFL-ASISEDCTVAVLDADFSEVFRDLS-HRDFVTGVAWSPLDHSKFT 328 Query: 460 SAAADETL 467 + D + Sbjct: 329 TVGWDHKV 336 Score = 75.6 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 29/175 (16%), Positives = 60/175 (34%), Gaps = 7/175 (4%) Query: 309 SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS 368 V + W + L + V +W E V +H VK ++ + Sbjct: 94 EAGVTDVAWVSEKGILV-ASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGT 152 Query: 369 NVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIW 428 ++ G D +++W++ A L + +AHS + + + K+ I ++++W Sbjct: 153 QAVS---GGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLW 209 Query: 429 KYPTMAKVA--ELKGHTSRVLSLTMSPD-GATVASAAADETLRLWRCFELDPARR 480 + + S+T P+ T A + L D A+ Sbjct: 210 DTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQT 264 Score = 67.1 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 25/134 (18%), Positives = 47/134 (35%), Gaps = 12/134 (8%) Query: 355 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSA-----VDAHSQVCSILWSP 409 + V VAW + ++A+ G + +W + L + V ++ Sbjct: 94 EAGVTDVAWVSEKGILVASDSGA----VELWEILEKESLLVNKFAKYEHDDIVKTLSVFS 149 Query: 410 HYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVA-SAAADETLR 468 + +S G + +W A + H+S V + P T+ S D + Sbjct: 150 DGTQAVS--GGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRIL 207 Query: 469 LWRCFELDPARRRE 482 LW + PA R + Sbjct: 208 LWDTRKPKPATRID 221 Score = 44.8 bits (104), Expect = 9e-05, Method: Composition-based stats. Identities = 15/93 (16%), Positives = 33/93 (35%), Gaps = 7/93 (7%) Query: 392 CLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK----GHTSRVL 447 C + V + V + W L++ + +W+ + K H V Sbjct: 87 CTAGVQTEAGVTDVAWVSEKGILVAS---DSGAVELWEILEKESLLVNKFAKYEHDDIVK 143 Query: 448 SLTMSPDGATVASAAADETLRLWRCFELDPARR 480 +L++ DG S D ++++W + + Sbjct: 144 TLSVFSDGTQAVSGGKDFSVKVWDLSQKAVLKS 176 >3F3P-A nrPDB Length = 351 Score = 98.7 bits (244), Expect = 5e-21, Method: Composition-based stats. Identities = 48/337 (14%), Positives = 109/337 (32%), Gaps = 43/337 (12%) Query: 182 RNDYYLNLV-DWSSGNVLAVALDNSVYLW--SASSGDILQLLQMEQPGEYISSVAWI--K 236 +D ++V D+ +V + D + ++ + + I ++ W + Sbjct: 10 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 69 Query: 237 EGNYLAVGTSSAEVQLWDVQQQKR---------LRNMTSHSARVGSLSWNSYIL----SS 283 G +A + V+LW+ + L + + S+ + L + Sbjct: 70 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC 129 Query: 284 GSRSGHIHHHD-VRVAEHHVATLSG-----------HSQEVCGLRWAPD----GRHLASG 327 G + +D + ++ TL+ H Q L W P + S Sbjct: 130 LGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSA 189 Query: 328 GNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW-QSNVLATGGGTSDRHIRIWN 386 ++ +G H+ +++++W P G D IRI+ Sbjct: 190 LEQAII---YQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFK 246 Query: 387 VCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQ----LVIWKYPTMAKVAELKGH 442 + + S S ++ + G + + + + ++E H Sbjct: 247 I-TEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDH 305 Query: 443 TSRVLSLTMSPDGATVASAAADETLRLWRCFELDPAR 479 V S++ + G ++SA D +RLW+ + + Sbjct: 306 NGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFK 342 Score = 67.9 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 51/323 (15%), Positives = 93/323 (28%), Gaps = 84/323 (26%) Query: 157 TPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGN----VLAVALDNSVYLWSAS 212 + K + + L +D + +DW+S + + + D +V LW Sbjct: 30 SSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEED 89 Query: 213 SGDILQ-------LLQMEQPGEYISSVAWIKE--GNYLAVGTSSAEVQLWDVQQQKRLRN 263 L + + SV + G LA + ++L+D + LR+ Sbjct: 90 PDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRS 149 Query: 264 MT-------------SHSARVGSLSWNS------YILSSGSRSGHIHHHDVRVAEHHVAT 304 T +H LSW + S I+ H A Sbjct: 150 WTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAK 209 Query: 305 LSGHSQEVCGLRWAPDG----RHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ------- 353 L GH + + WAP + +A+G D + ++ ++ T Sbjct: 210 LPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNS 269 Query: 354 -----------------------------------HQGAVKAVAWCPWQSNVLATGGGTS 378 H G V +V+W + + + G Sbjct: 270 ADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAG---D 326 Query: 379 DRHIRIWNV---CSGACLSAVDA 398 D +R+W C+S + A Sbjct: 327 DGKVRLWKATYSNEFKCMSVITA 349 Score = 65.6 bits (158), Expect = 5e-11, Method: Composition-based stats. Identities = 29/171 (16%), Positives = 63/171 (36%), Gaps = 26/171 (15%) Query: 307 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAW-CP 365 GH V + + GRH+A+ +D + V+ W ++ H ++ A+ W P Sbjct: 9 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 68 Query: 366 WQSNVLATGGGTSDRHIRIW--NVCSGAC-------LSAV-DAHSQVCSILWSPHYKELI 415 ++A+ + D+ +++W + C L + D+ + S+ ++P + L Sbjct: 69 EYGRIIASA--SYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLK 126 Query: 416 SGHGFAQNQLVIW------KYPTMAKVAELK-------GHTSRVLSLTMSP 453 L ++ + +E+K H L+ P Sbjct: 127 LACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCP 177 Score = 47.1 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 15/94 (15%), Positives = 37/94 (39%), Gaps = 9/94 (9%) Query: 397 DAHSQ-VCSILWSPHYKELISGHGFAQNQLVIW----KYPTMAKVAELKGHTSRVLSLTM 451 H V +++ + + + + + + ++ + H S ++++ Sbjct: 8 SGHDDLVHDVVYDFYGRHVATCS--SDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW 65 Query: 452 -SPD-GATVASAAADETLRLWRCFELDPARRRER 483 SP+ G +ASA+ D+T++LW R Sbjct: 66 ASPEYGRIIASASYDKTVKLWEEDPDQEECSGRR 99 >3JZG-A nrPDB Length = 402 Score = 97.2 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 44/296 (14%), Positives = 94/296 (31%), Gaps = 61/296 (20%) Query: 231 SVAWIKEGN----YLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY---ILSS 283 + AW + N LAV S +++ + + +++ H + L ++ +L S Sbjct: 110 TCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLS 169 Query: 284 GSRSGHIHHHDVRVAEHHVATL---SGHSQEVCGLRWAPDGRHLASGGNDNLVNVW---- 336 S+ + +++ VA GH EV + G + S G D+ + +W Sbjct: 170 VSKDHALRLWNIQTDTL-VAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 228 Query: 337 ----PSAPGEGGWVPLQTFTQ----------------HQGAVKAVAWCPWQSNVLATGGG 376 + + P +T H+ V V W Sbjct: 229 KRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGD-----LILSK 283 Query: 377 TSDRHIRIWNVCSGA----CLSAVDAHS-----------QVCSILWSPHYKELISGHGFA 421 + + I W + +++ + + +S + + + G Sbjct: 284 SCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQ 343 Query: 422 QNQLVIWKY----PTMAKVAELKGHT--SRVLSLTMSPDGATVASAAADETLRLWR 471 +L +W P AK L H + + + S D + + + D ++ W Sbjct: 344 VGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 399 Score = 72.5 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 35/240 (14%), Positives = 77/240 (32%), Gaps = 49/240 (20%) Query: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQM-EQPGEYISSVAWIKEGNYLAVGTSSAEVQ 251 +L+V+ D+++ LW+ + ++ + E + + S + G + ++ Sbjct: 163 DPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLK 222 Query: 252 LWDVQQQKRLRNMTS----------------------------HSARVGSLSWNSYILSS 283 LW + ++ + + H V + W ++ S Sbjct: 223 LWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILS 282 Query: 284 GSRSGHIHHH---------DVRVAEHHVATLSGHSQ----EVCGLRWAPD--GRHLASGG 328 S I D T+ G ++ +R++ D + LA G Sbjct: 283 KSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGN 342 Query: 329 NDNLVNVWPSAPGEGGWVPLQTFTQHQ--GAVKAVAWCPWQSNVLATGGGTSDRHIRIWN 386 + VW + T T H+ A++ ++ S ++A D I W+ Sbjct: 343 QVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAV---CDDASIWRWD 399 Score = 67.1 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 42/187 (22%), Positives = 71/187 (37%), Gaps = 18/187 (9%) Query: 300 HHVATL-SGHSQEVCGLRWAP-----DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ 353 V +L H+Q + G+++ D A+ G+ N V ++ +G LQ++ Sbjct: 44 KCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGS-NRVTLYECHS-QGEIRLLQSYVD 101 Query: 354 HQGAVK----AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWS 408 A + S+ L G+ IRI N + C+ H + + + + Sbjct: 102 ADADENFYTCAWTYDSNTSHPLLAVAGSR-GIIRIINPITMQCIKHYVGHGNAINELKFH 160 Query: 409 PHYKELISGHGFAQNQLVIWKYPTMAKVAEL---KGHTSRVLSLTMSPDGATVASAAADE 465 P L+ + L +W T VA +GH VLS G + S D Sbjct: 161 PRDPNLLL-SVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDH 219 Query: 466 TLRLWRC 472 +L+LWR Sbjct: 220 SLKLWRI 226 Score = 42.1 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 26/174 (14%), Positives = 65/174 (37%), Gaps = 34/174 (19%) Query: 170 SLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYI 229 + +I + Y++ V W +L+ + +N++ W G + + +P E Sbjct: 254 KIHFPDFSTRDIHRN-YVDCVRWLGDLILSKSCENAIVCW--KPGKMEDDIDKIKPSESN 310 Query: 230 SSVAWIKEGNYLAVGTSS-AEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSG 288 ++ +G ++ +W ++ S+ + +L+ G++ G Sbjct: 311 VTI----------LGRFDYSQCDIWYMR---------------FSMDFWQKMLALGNQVG 345 Query: 289 HIHHHDVRVAEHH---VATLSGHS--QEVCGLRWAPDGRHLASGGNDNLVNVWP 337 ++ D+ V + H TL+ H + ++ D L + +D + W Sbjct: 346 KLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 399 >3W15-A nrPDB Length = 368 Score = 95.6 bits (236), Expect = 4e-20, Method: Composition-based stats. Identities = 43/246 (17%), Positives = 83/246 (33%), Gaps = 44/246 (17%) Query: 268 SARVGSLSWNSY---ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWA-PDGRH 323 + L+WN + G + D E +A H +EV W + ++ Sbjct: 62 QDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQN 121 Query: 324 LASGGNDNLVNVWP--------------------SAPGEGGWVPLQTFTQ---HQGAVKA 360 S D + +W P + ++FT ++ V Sbjct: 122 FLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQ 181 Query: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVC--SGACLSAVDAHSQVCSILWS-PHYKELISG 417 + P N++ + G S + ++++ SG + HS + ++ Y+ + Sbjct: 182 AQFSPHDQNLVLSCSGNS--YASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVA 239 Query: 418 HGFAQNQLVIWKYP----------TMAKVAELK-GHTSRVLSLTMSP-DGATVASAAADE 465 G N + IW + + E+ H + +T SP + SA+ D Sbjct: 240 TGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDM 299 Query: 466 TLRLWR 471 T R+WR Sbjct: 300 TCRIWR 305 Score = 91.8 bits (226), Expect = 6e-19, Method: Composition-based stats. Identities = 46/293 (15%), Positives = 87/293 (29%), Gaps = 59/293 (20%) Query: 152 YSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS---SGNVLAVALDNSVYL 208 + + T R + A ++ + +W+ N L+ + D S+ + Sbjct: 74 HENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKI 133 Query: 209 WSASSGDILQLLQ----------------------MEQPGEYISSV---AWIK-EGNYLA 242 WS L L + + V + + N + Sbjct: 134 WSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVL 193 Query: 243 VGTSSAEVQLWDVQ--QQKRLRNMTSHSA-RVGSLSWN---SYILSSGSRSGHIHHHDVR 296 + ++ L+D++ K N HS + +N Y++++G I D+R Sbjct: 194 SCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIR 253 Query: 297 VAEHHVATLS----------GHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGW 345 + + L H + + W+P L S D +W +G Sbjct: 254 MLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAK 313 Query: 346 VPLQT------------FTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWN 386 +T FTQH V W W D ++ +WN Sbjct: 314 ETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGY-VASTAWDGNLFVWN 365 Score = 87.5 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 50/330 (15%), Positives = 101/330 (30%), Gaps = 80/330 (24%) Query: 190 VDWSS---GNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWI--KEGNYLAVG 244 + W+ VL D ++ L+ + + + ++ + S W N+L Sbjct: 68 LAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAI-FKEHEREVFSCNWNLVNRQNFL-SS 125 Query: 245 TSSAEVQLWDVQQQKRL------------------------RNMTSHSARVGSL---SWN 277 + +++W +++ L ++ T S + ++ Sbjct: 126 SWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFS 185 Query: 278 SY---ILSSGSRSGHIHHHDVRVAE-HHVATLSGHSQ-EVCGLRWAPDGRHLA-SGGNDN 331 + ++ S S + + D+R+ + HS E + ++ +GG DN Sbjct: 186 PHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDN 245 Query: 332 LVNVWPSAPGEGGWVPLQTF-------TQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRI 384 + +W L H A++ V W P SN+L + + D RI Sbjct: 246 AIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSA--SYDMTCRI 303 Query: 385 W-NVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHT 443 W ++ + +S + + H+ Sbjct: 304 WRDLSNDGAKETYKTNS-----------------TDATKGSIF-----------NFTQHS 335 Query: 444 SRVLSLTMSPDGA--TVASAAADETLRLWR 471 V S G VAS A D L +W Sbjct: 336 EFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 >5FA5-B nrPDB Length = 367 Score = 95.2 bits (235), Expect = 6e-20, Method: Composition-based stats. Identities = 48/275 (17%), Positives = 99/275 (36%), Gaps = 19/275 (6%) Query: 169 PSLPDRILDAPEIRNDYYLNLVDWSSGN-VLAVALDNSVYLW--SASSGDILQLLQMEQP 225 + P+ + ++ + + + W +L + +V LW + I+ + Sbjct: 90 CAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEH 149 Query: 226 GEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY---ILS 282 + +S+V+ + G G+ +++WD+ QQ L + +H+A+V ++ + + + Sbjct: 150 DDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL 209 Query: 283 SGSRSGHIHHHDVRVAEHHVATLSGHSQE---VCGLRWAPDGR-HLASGGNDNLVNVWPS 338 S S I D R A+ G S L W P G + V++ Sbjct: 210 SCSEDNRILLWDTR--CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD- 266 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 + + H V + + P LA+ + D + + + + Sbjct: 267 ---TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLAS--LSEDCSLAVLDSSLSELFRSQAH 321 Query: 399 HSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTM 433 V WSP L++ G +Q+V PT Sbjct: 322 RDFVRDATWSPLNHSLLTTVG-WDHQVVHHVVPTE 355 Score = 94.8 bits (234), Expect = 8e-20, Method: Composition-based stats. Identities = 45/229 (19%), Positives = 77/229 (33%), Gaps = 16/229 (6%) Query: 268 SARVGSLSW-NSYILSSGSRSGHIHHHDVRVAEHHVATLS---GHSQEVCGLRWAPDGRH 323 A V L+W + S SG + ++ E + + H V + G Sbjct: 105 EAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQ 164 Query: 324 LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIR 383 SG D + VW A V L ++ H V VA P + +V + + D I Sbjct: 165 AVSGSKDICIKVWDLA----QQVVLSSYRAHAAQVTCVAASPHKDSVFLSC--SEDNRIL 218 Query: 384 IWNVC---SGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK 440 +W+ + + S+ W P E + G + + + + V Sbjct: 219 LWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSE-VFVFGDENGTVSLVDTKSTSCVLSSA 277 Query: 441 GHTSRVLSLTMSPDG-ATVASAAADETLRLWRCFELDPARRREREKASA 488 H+ V L SP +AS + D +L + L R + + Sbjct: 278 VHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSELFRSQAHRDFV 325 Score = 94.5 bits (233), Expect = 1e-19, Method: Composition-based stats. Identities = 47/248 (18%), Positives = 101/248 (40%), Gaps = 17/248 (6%) Query: 229 ISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRL----RNMTSHSARVGSLSW--NSYILS 282 ++ + W+ E L V + S V+LW++ + + L H V ++S + Sbjct: 108 VADLTWVGERGIL-VASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAV 166 Query: 283 SGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWPSAPG 341 SGS+ I D+ + +++ H+ +V + +P S DN + +W + Sbjct: 167 SGSKDICIKVWDL-AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCP 225 Query: 342 EGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ 401 + + + ++AW P QS V G + + + + S +C+ + HSQ Sbjct: 226 KPASQIGCSAPGYL--PTSLAWHPQQSEVF--VFGDENGTVSLVDTKSTSCVLSSAVHSQ 281 Query: 402 -VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP-DGATVA 459 V +++SPH + L + +++++ + H V T SP + + + Sbjct: 282 CVTGLVFSPHSVPFL-ASLSEDCSLAVLD-SSLSELFRSQAHRDFVRDATWSPLNHSLLT 339 Query: 460 SAAADETL 467 + D + Sbjct: 340 TVGWDHQV 347 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 14/91 (15%), Positives = 33/91 (36%), Gaps = 7/91 (7%) Query: 388 CSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA--KVAEL--KGHT 443 G C + V + V + W L++ + +W+ V++ H Sbjct: 94 NEGFCSAGVQTEAGVADLTWVGERGILVAS---DSGAVELWELDENETLIVSKFCKYEHD 150 Query: 444 SRVLSLTMSPDGATVASAAADETLRLWRCFE 474 V ++++ G S + D +++W + Sbjct: 151 DIVSTVSVLSSGTQAVSGSKDICIKVWDLAQ 181 >3EI3-B nrPDB Length = 383 Score = 94.8 bits (234), Expect = 8e-20, Method: Composition-based stats. Identities = 50/316 (15%), Positives = 96/316 (30%), Gaps = 30/316 (9%) Query: 179 PEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK-E 237 P R L V + + LW + +Q PG+ I+ + + + Sbjct: 71 PFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQFN 130 Query: 238 GNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSA-----RVGSLSWNSYILSSGSRSGHIHH 292 N L V + L D ++ + +S + +L++G Sbjct: 131 TNQLFVSSIRGATTLRDF-SGSVIQVFAKTDSWDYWYCCVDVSVSRQMLATG--DSTGRL 187 Query: 293 HDVRVAEHHVATLSGHSQEVCGLRWAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTF 351 + + H + H +V + P L A+ D V +W + + Sbjct: 188 LLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEM 247 Query: 352 TQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV-------DAHSQVCS 404 H+ V A + P S L T IR+++ + + H Sbjct: 248 -PHEKPVNAAYFNPTDSTKLLTTDQR--NEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIK 304 Query: 405 ILWSPHYKELISGHGFAQN-------QLVIWKYPTMAKVAELK--GHTSRVLSLTMSPDG 455 W P Y +++G + I+ + V +L+ + SP G Sbjct: 305 ATWHPMYDLIVAGRYPDDQLLLNDKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSPTG 364 Query: 456 ATVASAAADETLRLWR 471 +AS + +W Sbjct: 365 DVLASG-MGFNILIWN 379 Score = 51.3 bits (121), Expect = 8e-07, Method: Composition-based stats. Identities = 27/171 (15%), Positives = 57/171 (33%), Gaps = 14/171 (8%) Query: 312 VCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370 V L W P +A G + +W A+ + + + +N Sbjct: 76 VTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQG--MGPGDAITGMKFNQFNTNQ 133 Query: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAHS----QVCSILWSPHYKELISGHGFAQNQLV 426 L +R + SG+ + C + S + L +G + L+ Sbjct: 134 LFVSSIRGATTLRDF---SGSVIQVFAKTDSWDYWYCCVDVSVSRQMLATGDSTGRLLLL 190 Query: 427 IWKYPTMAKVAELKGHTSRVLSLTMSPDGATV-ASAAADETLRLWRCFELD 476 ++ + K H ++V +P + A+++ D T++LW + Sbjct: 191 ---GLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIK 238 >4OWR-A nrPDB Length = 339 Score = 94.5 bits (233), Expect = 9e-20, Method: Composition-based stats. Identities = 40/295 (13%), Positives = 79/295 (26%), Gaps = 71/295 (24%) Query: 268 SARVGSLSWNS-----YILSSGSRSGHIHHHDVRVAEHHVAT-LSGHSQEVCGLRWAPDG 321 +G LS++ L +GS + + +V+ + + H+ V + W+ DG Sbjct: 10 DDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDG 69 Query: 322 RHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRH 381 + + D +W + + QH VK + W N G+ D+ Sbjct: 70 SKVFTASCDKTAKMWDLSSNQAI-----QIAQHDAPVKTIHWIKA-PNYSCVMTGSWDKT 123 Query: 382 IRIWNVCSGACLSAVD-------------------------------------------A 398 ++ W+ S + + Sbjct: 124 LKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLK 183 Query: 399 HSQVCSILWSPHYKELI-SGHGFAQNQLVIWKYPTMAKVA---ELKGHTSR--------- 445 H C ++ + G + ++ I K H S Sbjct: 184 HQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQD 243 Query: 446 ---VLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 V + P T+A+ +D W + E+ + H G Sbjct: 244 IYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNG 298 Score = 80.2 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 38/307 (12%), Positives = 93/307 (30%), Gaps = 35/307 (11%) Query: 183 NDYYLNLVDWSS-----GNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKE 237 D + + +S ++A + N V W + + V W + Sbjct: 9 PDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDD 68 Query: 238 GNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW----NSYILSSGSRSGHIHHH 293 G+ + + ++WD+ + ++ + H A V ++ W N + +GS + Sbjct: 69 GSKVFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFW 127 Query: 294 DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ 353 D R + + + + + + V+ + +++ + Sbjct: 128 DTRSSNPMMVLQLPERCYCADVIY----PMAVVATAERGLIVYQLENQPSEFRRIESPLK 183 Query: 354 HQGAVKAVAWCPWQSNVLA-TGGGTSDRHIRIWNVCSGACLS---AVDAH---------- 399 HQ + VA + N G+ + + I + H Sbjct: 184 HQH--RCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAP 241 Query: 400 ---SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA 456 V I + P + L + + + W K+ + + + + +G Sbjct: 242 QDIYAVNGIAFHPVHGTLATVG--SDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGN 299 Query: 457 TVASAAA 463 A A++ Sbjct: 300 IFAYASS 306 Score = 58.3 bits (139), Expect = 8e-09, Method: Composition-based stats. Identities = 42/255 (16%), Positives = 75/255 (29%), Gaps = 74/255 (29%) Query: 190 VDWSSG--NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY--LAVGT 245 V WS V + D + +W SS +Q+ Q + P + ++ WIK NY + G+ Sbjct: 63 VCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAP---VKTIHWIKAPNYSCVMTGS 119 Query: 246 SSAEVQLWDVQQQKRLRNMT---------------------------------------- 265 ++ WD + + + Sbjct: 120 WDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIE 179 Query: 266 ---SHSARVGSLSWN----SYILSSGSRSGHIHHHDVR--VAEHHVATLSGHS------- 309 H R ++ + + GS G + H + T H Sbjct: 180 SPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTS 239 Query: 310 -----QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 V G+ + P LA+ G+D + W + L+T Q + A + Sbjct: 240 APQDIYAVNGIAFHPVHGTLATVGSDGRFSFWD----KDARTKLKTSEQLDQPISACCFN 295 Query: 365 PWQSNVLATGGGTSD 379 N+ A + D Sbjct: 296 -HNGNIFAYAS-SYD 308 Score = 51.3 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 19/95 (20%), Positives = 36/95 (37%), Gaps = 7/95 (7%) Query: 395 AVDAHSQVCSILWSPH---YKELISGHGFAQNQLVIWKYPT--MAKVAELKGHTSRVLSL 449 + + +SP LI+G N + W+ + HT VL + Sbjct: 6 TSSPDDSIGCLSFSPPTLPGNFLIAGS--WANDVRCWEVQDSGQTIPKAQQMHTGPVLDV 63 Query: 450 TMSPDGATVASAAADETLRLWRCFELDPARRRERE 484 S DG+ V +A+ D+T ++W + + + Sbjct: 64 CWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHD 98 Score = 34.0 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 11/102 (10%), Positives = 26/102 (25%), Gaps = 6/102 (5%) Query: 210 SASSGDILQLLQMEQPGE----YISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMT 265 + + ++ +A+ LA S WD + +L+ Sbjct: 224 DNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSE 283 Query: 266 SHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATL 305 + + + N I + S H+ + Sbjct: 284 QLDQPISACCFNHNGNIFAYASSYDWSKGHEFYNPQKKNYIF 325 >3I2N-A nrPDB Length = 357 Score = 92.1 bits (227), Expect = 5e-19, Method: Composition-based stats. Identities = 50/311 (16%), Positives = 114/311 (36%), Gaps = 55/311 (17%) Query: 206 VYLWSASSGDILQLLQMEQPGEYISSVAW---IKEGNYLAVGTSSAEVQLWDVQQQK-RL 261 + L+ GD L+LL+ + + I + + YLA G + +W+++ + + Sbjct: 46 IQLYEIQHGD-LKLLREIEKAKPIKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEMPV 104 Query: 262 RNMTSHSARVGSLSWNSYI--------LSSGSRSGHIHHHDVRVAEHHVATLS----GHS 309 ++ H + ++ + + +GSR G + D R + VA + + Sbjct: 105 YSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENK 164 Query: 310 QEVCGLRW----APDGRHLASGGNDN-LVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 ++ + + + R + G DN + ++ W T + V ++ + Sbjct: 165 RDCWTVAFGNAYNQEER-VVCAGYDNGDIKLFDLRNMALRWE-----TNIKNGVCSLEFD 218 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAV-----DAH-SQVCSILWSPHYKELISGH 418 ++ + + ++++ + AH S V + P +EL Sbjct: 219 RKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTA 278 Query: 419 GFAQNQLVIWKYP-------------------TMAKVAELKGHTSRVLSLTMSPDGATVA 459 G A L +WKY +++ + + T + SL SPD + Sbjct: 279 GGA-GGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLC 337 Query: 460 SAAA-DETLRL 469 ++ D+T+R+ Sbjct: 338 VCSSFDQTVRV 348 Score = 89.1 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 41/294 (13%), Positives = 99/294 (33%), Gaps = 33/294 (11%) Query: 223 EQPGEYISSVAWIKEGNYLAV----GTSSAEVQLWDVQQQ--KRLRNMTSHSARVGSLSW 276 + + W+ + +QL+++Q K LR + + + ++ Sbjct: 15 KGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEK-AKPIKCGTF 73 Query: 277 NS-----YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRH------LA 325 + L++G G++H ++ E V ++ GH + + + + Sbjct: 74 GATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIV 133 Query: 326 SGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG-AVKAVAW-CPWQSNVLATGGGTSDRHIR 383 +G D V VW + ++ VA+ + G + I+ Sbjct: 134 TGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIK 193 Query: 384 IWNVCSGACLSAVDAHSQVCSILW---SPHYKELISGHGFAQNQLVIWKYPTMAKVAEL- 439 ++++ + A + + VCS+ + +L++ + + ++ T Sbjct: 194 LFDLRNMALRWETNIKNGVCSLEFDRKDISMNKLVATS--LEGKFHVFDMRTQHPTKGFA 251 Query: 440 ----KGHTSRVLSLTMSPDGATVA-SAAADETLRLWRCFELDPARRREREKASA 488 K H S V + P + +A L LW+ P +R +++ Sbjct: 252 SVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEY--PIQRSKKDSEGI 303 Score = 66.3 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 38/221 (17%), Positives = 74/221 (33%), Gaps = 35/221 (15%) Query: 196 NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSV-------AWIKEGNYLAVGTSSA 248 ++ + D +V +W D GE A+ +E + G + Sbjct: 131 EIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNG 190 Query: 249 EVQLWDVQQQKRLRNMTSHSARVGSLSWNSY-----ILSSGSRSGHIHHHDVRVAEHHVA 303 +++L+D++ LR T+ V SL ++ L + S G H D+R Sbjct: 191 DIKLFDLRNM-ALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKG 249 Query: 304 ----TLSGHSQEVCGLRWAPDGR-HLASGGNDNLVNVWPS-----APGE----------G 343 + H V +R P R + G +++W + G Sbjct: 250 FASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVAG 309 Query: 344 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRI 384 LQ T + ++ W P + + + D+ +R+ Sbjct: 310 SVSLLQNVTLSTQPISSLDWSPDKRGLCVCS--SFDQTVRV 348 >5WLC-LN nrPDB Length = 776 Score = 91.4 bits (225), Expect = 7e-19, Method: Composition-based stats. Identities = 54/269 (20%), Positives = 92/269 (34%), Gaps = 36/269 (13%) Query: 227 EYISSVAWIKEGNY---------LAVGTSSAEVQLWDVQQQ--KRLRNMTSHSARVGSLS 275 I+S+A+ + N LA+G S+ +++W+ + + + + L Sbjct: 44 ATITSLAFSHKSNINKLTPSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLC 103 Query: 276 WN-----SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGND 330 W+ S L S S + D+ + +S + + L S G D Sbjct: 104 WSNVNGESLRLFSIGGSTVVTEWDLATG-LPLRNYDCNSGVIWSISINDSQDKL-SVGCD 161 Query: 331 N-LVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS 389 N V + + G G + + V +AW GG SD IRIW+ Sbjct: 162 NGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDD----FVIGGCSDGRIRIWSAQK 217 Query: 390 -----GACLSAVDAHSQ------VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAE 438 G L + V S+++ P ++ G + + W + Sbjct: 218 NDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQI--ASGDSTGSIKFWDFQFATLNQS 275 Query: 439 LKGHTSRVLSLTMSPDGATVASAAADETL 467 K H + VL LT D V SA D + Sbjct: 276 FKAHDADVLCLTTDTDNNYVFSAGVDRKI 304 Score = 89.5 bits (220), Expect = 3e-18, Method: Composition-based stats. Identities = 57/331 (17%), Positives = 101/331 (30%), Gaps = 32/331 (9%) Query: 164 TCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQME 223 CR++ P I +N + S + + ++ +W+ + +++ Sbjct: 35 RCRFVDFTPATITSLAFSH-KSNINKLTPSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEG 93 Query: 224 QPGEYISSVAWIK---EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYI 280 I + W E L S V WD+ LRN +S + S+S N Sbjct: 94 GKDRSIEGLCWSNVNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQ 153 Query: 281 --LSSGSRSGHIHHHDVRVAE---HHVATLSGHSQEVCGLRWAPDGRHLASGGN-DNLVN 334 LS G +G + D+ H L V L W D GG D + Sbjct: 154 DKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDD--FVIGGCSDGRIR 211 Query: 335 VWPSA-PGEGGWVPLQTFTQHQGA-----VKAVAWCPWQSNVLATGGGTSDRHIRIWNVC 388 +W + E L T + V +V + P + + I+ W+ Sbjct: 212 IWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDST---GSIKFWDFQ 268 Query: 389 SGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAE---------- 438 + AH L + + G ++ + T Sbjct: 269 FATLNQSFKAHDADVLCLTTDTDNNYVFSAGV-DRKIFQFSQNTNKSQKNNRWVNSSNRL 327 Query: 439 LKGHTSRVLSLTMSPDGATVASAAADETLRL 469 L G+ R + S + S ++TL + Sbjct: 328 LHGNDIRAICAYQSKGADFLVSGGVEKTLVI 358 Score = 82.1 bits (201), Expect = 6e-16, Method: Composition-based stats. Identities = 49/349 (14%), Positives = 118/349 (33%), Gaps = 47/349 (13%) Query: 177 DAPEIRNDYYLNLVDWSSGNVLAVA-LDNSVYLWSA-----SSGDILQLLQMEQPGEY-- 228 D +R + + + W + + D + +WSA + G +L +++++ + Sbjct: 180 DTILMRQEARVLTLAWKKDDFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKEST 239 Query: 229 -ISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS--WNSYILSSGS 285 + SV ++ + +A G S+ ++ WD Q ++ +H A V L+ ++ + S Sbjct: 240 LVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAG 299 Query: 286 RSGHIHHH--DVRVAEHHVATLSG-----HSQEVCGLRW--APDGRHLASGGNDNLVNVW 336 I + ++ + ++ H ++ + + L SGG + + + Sbjct: 300 VDRKIFQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVIN 359 Query: 337 PSAP-GEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGA---- 391 G + + T + V + ++ + + ++IW + + + Sbjct: 360 SLTSFSNGNYRKMPTVEPYSKNVLV----NKEQRLVVSWSES---TVKIWTMGTDSSTEQ 412 Query: 392 -----CLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRV 446 C + + + SP + L+ G + KV +L Sbjct: 413 NYKLVCKLTLKDDQNISTCSLSPDGQVLVVGRPSTTKVFHLQPVGNKLKVTKLDNDLLLR 472 Query: 447 LS---LTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSS 492 S + + V + D F +D E EK + Sbjct: 473 TSTKLVKFIDNSKIVICSCED------DVFIVD-LESEEDEKPQEVELL 514 >5OV3-A nrPDB Length = 381 Score = 88.3 bits (217), Expect = 8e-18, Method: Composition-based stats. Identities = 47/305 (15%), Positives = 94/305 (30%), Gaps = 63/305 (20%) Query: 224 QPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYIL 281 + + + G LAVG + + +WD + + +++H V SL W + + L Sbjct: 23 DCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKL 82 Query: 282 SSGSRSGHIHHHDVRVAEHH--------VATLSGHSQEVCGLRWAP-------------- 319 S S + DV + + + H ++ + P Sbjct: 83 VSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSK 142 Query: 320 --------DGRHLASGGNDNL--------VNVWPSAPGEGGWVPLQTF-----TQHQGAV 358 D D + +F T + A+ Sbjct: 143 HVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAI 202 Query: 359 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCS------------GACLSAVDAHSQVCSIL 406 K++ + S L T+DR IR+++ L + + Sbjct: 203 KSIEFARKGSCFLI---NTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCC 259 Query: 407 WSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSR-VLSLTMSPDGATVASAAADE 465 +S + +++G Q+ L IW+ V L G +L + P +AS ++ Sbjct: 260 FSGDGEYIVAGSA-RQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISS-G 317 Query: 466 TLRLW 470 + +W Sbjct: 318 VVSIW 322 Score = 86.4 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 42/210 (20%), Positives = 77/210 (36%), Gaps = 15/210 (7%) Query: 273 SLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGND 330 + ++N +L+ G G I D +S H VC L W+ DG L S D Sbjct: 30 TCTFNRWGTLLAVGCNDGRIVIWDFLT-RGIAKIISAHIHPVCSLCWSRDGHKLVSASTD 88 Query: 331 NLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG 390 N+V+ W G+ + V + P N + + + S Sbjct: 89 NIVSQWDVLSGDCDQRFRF-----PSPILKVQYHPRDQNKVLVCP-MKSAPVMLTLSDSK 142 Query: 391 ACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK-----GHTSR 445 + VD S + + E I G A+ ++++ K + VA + +T+ Sbjct: 143 HVVLPVDDDSDLNVVASFDRRGEYIY-TGNAKGKILVLKTDSQDLVASFRVTTGTSNTTA 201 Query: 446 VLSLTMSPDGATVASAAADETLRLWRCFEL 475 + S+ + G+ AD +R++ E+ Sbjct: 202 IKSIEFARKGSCFLINTADRIIRVYDGREI 231 Score = 64.4 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 18/66 (27%), Positives = 27/66 (40%) Query: 415 ISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474 + G ++VIW + T + H V SL S DG + SA+ D + W Sbjct: 39 LLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLS 98 Query: 475 LDPARR 480 D +R Sbjct: 99 GDCDQR 104 >6EM1-m nrPDB Length = 807 Score = 86.0 bits (211), Expect = 4e-17, Method: Composition-based stats. Identities = 58/411 (14%), Positives = 119/411 (28%), Gaps = 60/411 (14%) Query: 102 ENSQTPTKKEHQKAWALNL-NGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQ---KAT 157 E S+ QK AL G+ + S AP +N+L + + + Sbjct: 358 EYSERERNFIPQKYSALRKVPGYGESIRERFERSLDLYLAPRVRKNKLNIDPNSLIPELP 417 Query: 158 PGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGD-- 215 + S + +D S + + D +V +W +G Sbjct: 418 SPKDLRPFPIRCSTIY-----AGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREV 472 Query: 216 --ILQLLQMEQPGEYISSVAWIKEGN--YLAVGTSSAEVQL------WDVQQQKRLRNMT 265 + E P +I + W + N LAV + +D++ + + Sbjct: 473 YRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIED 532 Query: 266 SH--------SARVGSLSWNSYILSSGSRSG-----------HIHHHD---VRVAEHHVA 303 ++ N G G + + + E + Sbjct: 533 GFGYDTFGTVKKSNLEVNENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDIC 588 Query: 304 TLSGHSQEVCGLRWAPDGRHLASGGND--NLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 361 + V L W G + + D N + P F + +G + Sbjct: 589 ITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSP---FKKSKGIIMDA 645 Query: 362 AWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV-DAHSQVCSILWSPHYKELISGHGF 420 + P++ + R++RI+++ + + + I P LI+ Sbjct: 646 KFHPFKPQLFVCSQ----RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASS-- 699 Query: 421 AQNQLVIWKYPTM-AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 +++ L+ H V S+ +SAA D T+ ++ Sbjct: 700 FDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVF 750 Score = 80.6 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 43/257 (16%), Positives = 86/257 (33%), Gaps = 53/257 (20%) Query: 224 QPGEYISSVAWIKEGNYLAVG---TSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY- 279 + + ++W ++G+Y + + V + V + + ++ + Sbjct: 592 SCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFK 651 Query: 280 -ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 L S+ ++ +D+ L G ++ + + P G +L + D V +W Sbjct: 652 PQLFVCSQ-RYVRIYDLSQQILVKKLLPG-ARWLSKIDIHPRGDNLIASSFDKRV-LWH- 707 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 + P +T H+ AV++V + + D I ++ Sbjct: 708 -DLDLASTPYKTLRYHEKAVRSVNFHK---KLPLFSSAADDGTIHVF------------- 750 Query: 399 HSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLT-----MSP 453 H+ V + K P + + +L GH + SL P Sbjct: 751 HATVYDDMM---------------------KNPMIVPLKKLTGH-KVINSLGVLDAIWHP 788 Query: 454 DGATVASAAADETLRLW 470 A + SA AD T RLW Sbjct: 789 REAWLFSAGADNTARLW 805 Score = 79.1 bits (193), Expect = 4e-15, Method: Composition-based stats. Identities = 31/178 (17%), Positives = 65/178 (36%), Gaps = 15/178 (8%) Query: 221 QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY- 279 ++ I + L V + V+++D+ QQ ++ + + + + + Sbjct: 634 PFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRG 692 Query: 280 -ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVN---- 334 L + S + HD+ +A TL H + V + + +S +D ++ Sbjct: 693 DNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHA 752 Query: 335 -VWPSAPGEGGWVPLQTFTQHQ----GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 387 V+ VPL+ T H+ V W P ++ + + G D R+W Sbjct: 753 TVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGA---DNTARLWTT 807 Score = 51.7 bits (122), Expect = 8e-07, Method: Composition-based stats. Identities = 12/48 (25%), Positives = 21/48 (43%) Query: 434 AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRR 481 GH +V +L++ P G +A+ + D T+R+W R Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRT 475 >6CB1-s nrPDB Length = 569 Score = 85.6 bits (210), Expect = 5e-17, Method: Composition-based stats. Identities = 52/390 (13%), Positives = 112/390 (28%), Gaps = 59/390 (15%) Query: 122 GFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQ---KATPGSSRKTCRYIPSLPDRILDA 178 G+ + S AP +N+L + + + + S Sbjct: 141 GYGESIRERFERSLDLYLAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIY----- 195 Query: 179 PEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGD----ILQLLQMEQPGEYISSVAW 234 + +D S + + D +V +W +G + E P +I + W Sbjct: 196 AGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEW 255 Query: 235 IKEGN--YLAVGTSSAEVQL------WDVQQQKRLRNMTSH--------SARVGSLSWNS 278 + N LAV + +D++ + + ++ N Sbjct: 256 NPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENG 315 Query: 279 YILSSGSRSG-----------HIHHHD---VRVAEHHVATLSGHSQEVCGLRWAPDGRHL 324 G G + + + E + + V L W G + Sbjct: 316 D----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYF 371 Query: 325 ASGGND--NLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHI 382 + D N + P F + +G + + P++ + R++ Sbjct: 372 VTVQPDSGNTSVLIHQVSKHLTQSP---FKKSKGIIMDAKFHPFKPQLFVCSQ----RYV 424 Query: 383 RIWNVCSGACLSAV-DAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTM-AKVAELK 440 RI+++ + + + I P LI+ +++ L+ Sbjct: 425 RIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASS--FDKRVLWHDLDLASTPYKTLR 482 Query: 441 GHTSRVLSLTMSPDGATVASAAADETLRLW 470 H V S+ +SAA D T+ ++ Sbjct: 483 YHEKAVRSVNFHKKLPLFSSAADDGTIHVF 512 Score = 81.4 bits (199), Expect = 9e-16, Method: Composition-based stats. Identities = 43/257 (16%), Positives = 86/257 (33%), Gaps = 53/257 (20%) Query: 224 QPGEYISSVAWIKEGNYLAVG---TSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY- 279 + + ++W ++G+Y + + V + V + + ++ + Sbjct: 354 SCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFK 413 Query: 280 -ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 L S+ ++ +D+ L G ++ + + P G +L + D V +W Sbjct: 414 PQLFVCSQ-RYVRIYDLSQQILVKKLLPG-ARWLSKIDIHPRGDNLIASSFDKRV-LWH- 469 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 + P +T H+ AV++V + + D I ++ Sbjct: 470 -DLDLASTPYKTLRYHEKAVRSVNFHK---KLPLFSSAADDGTIHVF------------- 512 Query: 399 HSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLT-----MSP 453 H+ V + K P + + +L GH + SL P Sbjct: 513 HATVYDDMM---------------------KNPMIVPLKKLTGH-KVINSLGVLDAIWHP 550 Query: 454 DGATVASAAADETLRLW 470 A + SA AD T RLW Sbjct: 551 REAWLFSAGADNTARLW 567 Score = 79.8 bits (195), Expect = 3e-15, Method: Composition-based stats. Identities = 31/178 (17%), Positives = 65/178 (36%), Gaps = 15/178 (8%) Query: 221 QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY- 279 ++ I + L V + V+++D+ QQ ++ + + + + + Sbjct: 396 PFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRG 454 Query: 280 -ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVN---- 334 L + S + HD+ +A TL H + V + + +S +D ++ Sbjct: 455 DNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHA 514 Query: 335 -VWPSAPGEGGWVPLQTFTQHQ----GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 387 V+ VPL+ T H+ V W P ++ + + G D R+W Sbjct: 515 TVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGA---DNTARLWTT 569 Score = 51.7 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 12/48 (25%), Positives = 21/48 (43%) Query: 434 AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRR 481 GH +V +L++ P G +A+ + D T+R+W R Sbjct: 190 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRT 237 >6C0F-s nrPDB Length = 807 Score = 85.2 bits (209), Expect = 7e-17, Method: Composition-based stats. Identities = 45/319 (14%), Positives = 96/319 (30%), Gaps = 51/319 (15%) Query: 190 VDWSSGNVLAVALDNSVYLWSASSGD----ILQLLQMEQPGEYISSVAWIKEGN--YLAV 243 +D S + + D +V +W +G + E P +I + W + N LAV Sbjct: 445 IDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAV 504 Query: 244 GTSSAEVQL------WDVQQQKRLRNMTSH--------SARVGSLSWNSYILSSGSRSG- 288 + +D++ + + ++ N G G Sbjct: 505 AVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGD----GDEDGE 560 Query: 289 ----------HIHHHD---VRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGND--NLV 333 + + + E + + V L W G + + D N Sbjct: 561 NESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTS 620 Query: 334 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACL 393 + P F + +G + + P++ + R++RI+++ + Sbjct: 621 VLIHQVSKHLTQSP---FKKSKGIIMDAKFHPFKPQLFVCSQ----RYVRIYDLSQQILV 673 Query: 394 SAV-DAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTM-AKVAELKGHTSRVLSLTM 451 + + I P LI+ +++ L+ H V S+ Sbjct: 674 KKLLPGARWLSKIDIHPRGDNLIASS--FDKRVLWHDLDLASTPYKTLRYHEKAVRSVNF 731 Query: 452 SPDGATVASAAADETLRLW 470 +SAA D T+ ++ Sbjct: 732 HKKLPLFSSAADDGTIHVF 750 Score = 81.0 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 43/257 (16%), Positives = 86/257 (33%), Gaps = 53/257 (20%) Query: 224 QPGEYISSVAWIKEGNYLAVG---TSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY- 279 + + ++W ++G+Y + + V + V + + ++ + Sbjct: 592 SCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFK 651 Query: 280 -ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 L S+ ++ +D+ L G ++ + + P G +L + D V +W Sbjct: 652 PQLFVCSQ-RYVRIYDLSQQILVKKLLPG-ARWLSKIDIHPRGDNLIASSFDKRV-LWH- 707 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 + P +T H+ AV++V + + D I ++ Sbjct: 708 -DLDLASTPYKTLRYHEKAVRSVNFHK---KLPLFSSAADDGTIHVF------------- 750 Query: 399 HSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLT-----MSP 453 H+ V + K P + + +L GH + SL P Sbjct: 751 HATVYDDMM---------------------KNPMIVPLKKLTGH-KVINSLGVLDAIWHP 788 Query: 454 DGATVASAAADETLRLW 470 A + SA AD T RLW Sbjct: 789 REAWLFSAGADNTARLW 805 Score = 79.4 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 31/178 (17%), Positives = 65/178 (36%), Gaps = 15/178 (8%) Query: 221 QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY- 279 ++ I + L V + V+++D+ QQ ++ + + + + + Sbjct: 634 PFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRG 692 Query: 280 -ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVN---- 334 L + S + HD+ +A TL H + V + + +S +D ++ Sbjct: 693 DNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHA 752 Query: 335 -VWPSAPGEGGWVPLQTFTQHQ----GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 387 V+ VPL+ T H+ V W P ++ + + G D R+W Sbjct: 753 TVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGA---DNTARLWTT 807 Score = 66.0 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 41/320 (12%), Positives = 90/320 (28%), Gaps = 45/320 (14%) Query: 210 SASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSA 269 I + +++ G +LA G+ V++W++ + + T Sbjct: 421 DLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDD 480 Query: 270 R------VGSLSWNSY----ILSSGSRSGH------IHHHDVRVAEHHVATLSGHSQEVC 313 + + WN IL+ I +D+ G + Sbjct: 481 EENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGK-TKIEDGFGYDTF 539 Query: 314 G------LRWAPDGRHLASGGND-----------NLVNVWPSAPGEGGWVPLQTFTQHQG 356 G L +G G D V W + + + Sbjct: 540 GTVKKSNLEVNENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKK 595 Query: 357 AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV-DAHSQVCSILWSPHYKELI 415 VK ++W + + + + I V S + + + P +L Sbjct: 596 TVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLF 655 Query: 416 SGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFEL 475 Q + I+ V +L + + + P G + +++ D+ + LW +L Sbjct: 656 VCS---QRYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWHDLDL 711 Query: 476 --DPARRREREKASAAKSSL 493 P + + + + Sbjct: 712 ASTPYKTLRYHEKAVRSVNF 731 Score = 57.1 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 31/266 (11%), Positives = 76/266 (28%), Gaps = 30/266 (11%) Query: 260 RLRNMTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQE-----V 312 H +V +LS + L++GS G + ++ T +E + Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHI 488 Query: 313 CGLRWAPD---GRHLASGGNDNLVNV-----WPSAPGEGGWVP----LQTFTQHQGAVKA 360 + W PD G + G + + V + + TF + + Sbjct: 489 ECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLE 548 Query: 361 VAWCPWQSN--VLATGGGTSDRHIRIWN------VCSGACLSAVDAHSQVCSILWSPHYK 412 V + + + WN + C+ + V + W Sbjct: 549 VNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICI-TISCKKTVKKLSWHRKGD 607 Query: 413 ELISGHGFAQNQ-LVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 ++ + N ++I + + K ++ P + + +R++ Sbjct: 608 YFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYD 666 Query: 472 CFELDPARRREREKASAAKSSLIHQG 497 + ++ +K + +G Sbjct: 667 LSQQILVKKLLPGARWLSKIDIHPRG 692 >6E29-D nrPDB Length = 345 Score = 84.1 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 40/252 (15%), Positives = 84/252 (33%), Gaps = 33/252 (13%) Query: 220 LQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN-- 277 + + + V + ++G++LA G V +WD++ R + HS + SLSW+ Sbjct: 19 ITNTIRSGHSTCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRC 78 Query: 278 SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVW 336 L S + + D++ + + V G P + A+ Sbjct: 79 GRYLLSACQGWKVILWDLQDGKRYREVRF--RAPVYGAELHPWNHHQFAAA--------- 127 Query: 337 PSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV 396 + V + V+ P +T + + Sbjct: 128 -LFEDQPMLVDI------TEPVEVRYVLPSVPKRTSTET----------DPALREKQAKE 170 Query: 397 DAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA 456 DA +I+++ L++G + +L I T + K + + +L ++ G Sbjct: 171 DAKHMTTAIVYTASGDHLLAGT--TKGRLNIIDARTREIIYSEKIASGIITTLRLTESGR 228 Query: 457 TVASAAADETLR 468 + A D +R Sbjct: 229 ELLVNAQDRIIR 240 Score = 69.4 bits (168), Expect = 4e-12, Method: Composition-based stats. Identities = 51/318 (16%), Positives = 102/318 (32%), Gaps = 50/318 (15%) Query: 195 GNVLAVAL-DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW 253 G+ LA D +V +W + + + ++ + I+S++W + G YL +V LW Sbjct: 37 GDFLASGRVDGTVVIWDLETMGVAR--KLRGHSKNITSLSWSRCGRYLLSACQGWKVILW 94 Query: 254 DVQQQKRLRNMTSHSARVGSL---SWNSYILSSGSRSGHIHHHDVRVAEHHVATLSG--- 307 D+Q KR R + A V WN + ++ D+ L Sbjct: 95 DLQDGKRYREVR-FRAPVYGAELHPWNHHQFAAALFEDQPMLVDITEPVEVRYVLPSVPK 153 Query: 308 ------------------HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQ 349 + + G HL +G +N+ + E + Sbjct: 154 RTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNIIDARTREIIYSEKI 213 Query: 350 TFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW--------NVCSGACLSAVDAH-- 399 G + + +L DR IR + ++ ++ Sbjct: 214 A----SGIITTLRLTESGRELLVNA---QDRIIRTFIVPNLSAADLDPDTIQLPLEHKFQ 266 Query: 400 SQVCSILWS----PHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDG 455 V + W+ E ++ + ++L IW+ + V L+G + P Sbjct: 267 DVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERGHGSLVRMLEGPKEEQGVIEWHPHR 326 Query: 456 ATVASAAAD-ETLRLWRC 472 A +A+ + + +W Sbjct: 327 ALLAACGLETGRINIWSV 344 Score = 61.3 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 20/80 (25%), Positives = 32/80 (40%), Gaps = 4/80 (5%) Query: 397 DAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA 456 HS + ++ L G +VIW TM +L+GH+ + SL+ S G Sbjct: 25 SGHS--TCVRFNRKGDFL--ASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGR 80 Query: 457 TVASAAADETLRLWRCFELD 476 + SA + LW + Sbjct: 81 YLLSACQGWKVILWDLQDGK 100 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 13/64 (20%), Positives = 22/64 (34%), Gaps = 3/64 (4%) Query: 429 KYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASA 488 YP GH+ + + G +AS D T+ +W + AR+ + Sbjct: 14 DYPENITNTIRSGHS---TCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNI 70 Query: 489 AKSS 492 S Sbjct: 71 TSLS 74 >5YZG-2 nrPDB Length = 646 Score = 82.9 bits (203), Expect = 3e-16, Method: Composition-based stats. Identities = 39/239 (16%), Positives = 81/239 (33%), Gaps = 27/239 (11%) Query: 254 DVQQQKRLRNMTSHSARVGSL-SWNSYILSSGSRSGHIHHHD-VRVAEHHVATLSGHSQE 311 ++ H + + + + + S GH+ + V H Sbjct: 76 NLPSASMYERSYMHRDVITHVVCTKTDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGV 135 Query: 312 VCGLRWAPDGRHLASGGNDNLVNVWPSA-------------PGEGGWVPLQTFTQHQGAV 358 + + + +G S G+D + V+ PG+ W A+ Sbjct: 136 IESIAVSSEGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEW-----IYCPGDAI 190 Query: 359 KAVAWCPWQSNVLATGGGTSDRH-IRIWNVCSGACLSAVDAHSQVCSILWSPHYKELIS- 416 +VA + + G D + I++ + L+ + + V + S +I Sbjct: 191 SSVAASEKSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLN-PVYKAVVSSDKSGMIEY 249 Query: 417 ----GHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 H + + V W+Y T + E + S+ SPDG +A+ +D +R++R Sbjct: 250 WTGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFR 308 Score = 60.2 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 36/302 (11%), Positives = 84/302 (27%), Gaps = 71/302 (23%) Query: 124 DVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRY----IPSLPD-RILDA 178 ++ E ++ Q E + R +AT RK + + +LP + + Sbjct: 26 ELSERELAVAVAVSQENDEENEERWVGPLPVEATLAKKRKVLEFERVYLDNLPSASMYER 85 Query: 179 PEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEG 238 + D ++V + ++ + D V W I + I S+A EG Sbjct: 86 SYMHRDVITHVVCTKTDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEG 145 Query: 239 NYLAVGTSSAEVQLWDVQQ----------------------------------------- 257 ++++DV Sbjct: 146 ALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPGDAISSVAASEKSTGKIFI 205 Query: 258 ------QKRLRNMTS-HSARVGSLSWNSYILSSGSRSGHIHH-----------------H 293 + L H++ + + N + S Sbjct: 206 YDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVNW 265 Query: 294 DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ 353 + + + + + + ++PDG+ +A+ G+D V ++ G+ V ++ + Sbjct: 266 EYKT-DTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGKLMRVFDESLSM 324 Query: 354 HQ 355 Sbjct: 325 FT 326 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 14/80 (17%), Positives = 30/80 (37%), Gaps = 4/80 (5%) Query: 399 HSQVCSILWSPHYKELISGHGFAQNQLVIWK--YPTMAKVAELKGHTSRVLSLTMSPDGA 456 H V + + +I+ + WK + V + H + S+ +S +GA Sbjct: 89 HRDVITHVVCTKTDFIITAS--HDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGA 146 Query: 457 TVASAAADETLRLWRCFELD 476 S D+ ++++ D Sbjct: 147 LFCSVGDDKAMKVFDVVNFD 166 >6F1U-h nrPDB Length = 612 Score = 81.4 bits (199), Expect = 8e-16, Method: Composition-based stats. Identities = 45/335 (13%), Positives = 98/335 (29%), Gaps = 50/335 (14%) Query: 138 QNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEI----RNDYYLNLVDWS 193 + Y L Y+ + ++ + + + Sbjct: 259 LDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFH 318 Query: 194 SGNVLAVALDNSVYLWSASSGDILQLLQM------EQPGEYISSVAWIKEGNYLAVGTSS 247 V+ + LW S + + Y +V + + L ++ Sbjct: 319 PNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTD 378 Query: 248 AEVQLWDV-------QQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRV 297 ++ W + + + + + V S+S+ + GS G + Sbjct: 379 GKICSWSLDMLSHPQDSMELVHKQSK-AVAVTSMSFPVGDVNNFVVGSEEGSV-----YT 432 Query: 298 AEHH------VATLSGHSQEVCGLRWAPD------GRHLASGGNDNLVNVWPSAPGEGGW 345 A H GH + G+ + D V +W + + Sbjct: 433 ACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNNK--- 489 Query: 346 VPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSA----VDAHSQ 401 PL +F + G V V W P + A G + +WN+ + + V+ + Sbjct: 490 -PLYSFEDNAGYVYDVMWSPTHPALFACVDGM--GRLDLWNLNNDTEVPTASISVEGNPA 546 Query: 402 VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKV 436 + + W+ +E+ G ++ Q+VI+ V Sbjct: 547 LNRVRWTHSGREI--AVGDSEGQIVIYDVGEQIAV 579 Score = 76.7 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 40/304 (13%), Positives = 88/304 (28%), Gaps = 43/304 (14%) Query: 227 EYISSVAWIKEGNYLAVGTS----------SAEVQLWDVQQQKRLRNMTSH-SARVGSLS 275 +S + W + L V + +W+++ +K H + V S + Sbjct: 254 RVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSAT 313 Query: 276 W---NSYILSSGSRSGHIHHHDVRVAEHHVATLS-----GHSQEVCGLRW--APDGRHLA 325 + + ++ G+ SG I D R + + H+ V + + +L Sbjct: 314 FAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLI 373 Query: 326 SGGNDNLVNVW------------PSAPGEGGWVPLQTFTQHQGAVK-AVAWCPWQSNVLA 372 S D + W + V + + + G V V S A Sbjct: 374 SISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTA 433 Query: 373 TGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPT 432 G+ ++ G ++ + H+ V ++ +S + + +W Sbjct: 434 CRHGSKAGISEMFEGHQG-PITGIHCHAAVGAVDFSH-----LFVTSSFDWTVKLWSTKN 487 Query: 433 MAKVAELKGHTSRVLSLTMSPDGATVASAAADETLR--LWRCFELDPARRREREKASAAK 490 + + + V + SP + + D R LW Sbjct: 488 NKPLYSFEDNAGYVYDVMWSPTHPALFAC-VDGMGRLDLWNLNNDTEVPTASISVEGNPA 546 Query: 491 SSLI 494 + + Sbjct: 547 LNRV 550 >1PI6-A nrPDB Length = 615 Score = 80.6 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 55/318 (17%), Positives = 123/318 (38%), Gaps = 38/318 (11%) Query: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEY--ISSVAWIKEGNYLAVGTSSAEV 250 S V+ V D + + SG+ L+ ++ +Q I +++W+ + A + A + Sbjct: 218 SGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL-DSQKFATVGADATI 276 Query: 251 QLWDVQQQKRLRNMTSHS-----ARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATL 305 ++WDV K ++ T +VG ++ + + S S G ++ +++ E + T+ Sbjct: 277 RVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEV-LKTI 335 Query: 306 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPG-EGGWVPLQTFTQHQGA------- 357 SGH++ + L P L SG D + W S+ + + + + Sbjct: 336 SGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISW 391 Query: 358 -----VKAVAWCPWQSNVL--------ATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCS 404 V + + S T T+D + I +G + +V +S + Sbjct: 392 DDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSA 451 Query: 405 ILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGH-TSRVLSLTMSPDGATVASAAA 463 + S +Y ++ N + ++K + +LK ++ +++SP +A+ Sbjct: 452 VSLSQNY---VAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDV 508 Query: 464 DETLRLWRCFELDPARRR 481 + L+ + R Sbjct: 509 MGKILLYDLQSREVKTSR 526 Score = 74.4 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 62/395 (15%), Positives = 134/395 (33%), Gaps = 61/395 (15%) Query: 123 FDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDR-----ILD 177 FD + + L+ Q +G L L SQK + T R + LD Sbjct: 234 FDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLD 293 Query: 178 APEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKE 237 ++ N + +V +G +++++LD ++ + ++L+ + G +V Sbjct: 294 KQQLGNQQ-VGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTV----- 347 Query: 238 GNYLAVGTSSAEVQLWDVQQ-----QKRLRNMTSHSA-RVGSLSWNSYI----------- 280 N L G+ + W + ++ + A S+SW+ + Sbjct: 348 -NPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFG 406 Query: 281 ----LSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDG-------RHLASGGN 329 ++S + G + + +G + +R G ++A G Sbjct: 407 SQPKVASANNDGFTAVLTNDDDLLILQSFTG--DIIKSVRLNSPGSAVSLSQNYVAVGLE 464 Query: 330 D-NLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC 388 + N + V+ + E + + + P ++ + A I ++++ Sbjct: 465 EGNTIQVFKLSDLEVSFDLKTPLRAKPSYI---SISPSETYIAAGDVM---GKILLYDLQ 518 Query: 389 SGACLSA--VDAHSQVCSILWSPHYK--------ELISGHGFAQNQLVIWKY-PTMAKVA 437 S ++ S++ +I W P K E + G + I+ M + Sbjct: 519 SREVKTSRWAFRTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIK 578 Query: 438 ELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 L H V +L +T+ S+ AD ++ W Sbjct: 579 ALNAHKDGVNNLLW-ETPSTLVSSGADACIKRWNV 612 Score = 74.0 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 47/311 (15%), Positives = 98/311 (31%), Gaps = 51/311 (16%) Query: 219 LLQMEQPGEYI-SSVAWIK--EGNYLAVGTSSAEVQLW--------DVQQQKRLRNMTSH 267 ++Q G + ++V + YL G S +V +W + + Sbjct: 56 VVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVL 115 Query: 268 SARVGSLSWN--SYILSS---GSRSGHIHH-HDVRVAEHHVATLSGHSQEVCGLRWAPDG 321 + + +SW+ L G + + D + + + +SGHSQ + Sbjct: 116 AGPISDISWDFEGRRLCVVGEGRDNFGVFISWD---SGNSLGEVSGHSQRINACHLKQSR 172 Query: 322 R-HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDR 380 + G+D V + P + +T + V+ V + P + T G SDR Sbjct: 173 PMRSMTVGDDGSVVFYQGPPFKFSASD-RTHHKQGSFVRDVEFSPDSGEFVITVG--SDR 229 Query: 381 HIRIWNVCSGACLSAVDAHSQ-----VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAK 435 I ++ SG L ++ + + ++ W K A + +W T Sbjct: 230 KISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKF---ATVGADATIRVWDVTTSKC 286 Query: 436 VAELKGHTSRVLSLT-----------MSPDGATVASAAADETLRLWRCFELDPARRRERE 484 V + +L ++ + S + D TL + + + Sbjct: 287 VQK--------WTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGH 338 Query: 485 KASAAKSSLIH 495 ++ Sbjct: 339 NKGITALTVNP 349 Score = 64.0 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 31/162 (19%), Positives = 65/162 (40%), Gaps = 19/162 (11%) Query: 194 SGNVLAVA--LDNSVYLWSASSGDILQLLQMEQPGEYISS-VAWIKEGNYLAVGTSSAEV 250 S N +AV N++ ++ S D+ ++ P S ++ Y+A G ++ Sbjct: 455 SQNYVAVGLEEGNTIQVFKLS--DLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKI 512 Query: 251 QLWDVQQQK-RLRNMTSHSARVGSLSWNS------------YILSSGSRSGHIHHHDVRV 297 L+D+Q ++ + ++++ ++SW ++++GS +I + V+ Sbjct: 513 LLYDLQSREVKTSRWAFRTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKR 572 Query: 298 AEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSA 339 + L+ H V L W L S G D + W Sbjct: 573 PMKIIKALNAHKDGVNNLLW-ETPSTLVSSGADACIKRWNVV 613 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 47/281 (16%), Positives = 93/281 (33%), Gaps = 37/281 (13%) Query: 227 EYISSVAWIKEGNYLA-VGTSSAEVQLWDVQQQK--RLRNMTSH-SARVGSLSWNS---- 278 + + +++ N +A SA V+ D K + T H S+ V ++ ++ Sbjct: 19 NFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGS 78 Query: 279 YILSSGSRSGHIHHH----DVRVAEHHVAT---LSGHSQEVCGLRWAPDGRHLASGGN-- 329 L SG SG + D V + + + W +GR L G Sbjct: 79 QYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGR 138 Query: 330 DNLVN--VWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 387 DN W S L + H + A QS + + D + + Sbjct: 139 DNFGVFISWDSGNS------LGEVSGHSQRIN--ACHLKQSRPMRSMTVGDDGSVVFYQG 190 Query: 388 CSGACLSAVDAHSQ----VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHT 443 ++ H + V + +SP E + G + ++ + + + ++ Sbjct: 191 PPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVG-SDRKISCFDGKSGEFLKYIEDDQ 249 Query: 444 ----SRVLSLTMSPDGATVASAAADETLRLWRCFELDPARR 480 + +L+ D A+ AD T+R+W ++ Sbjct: 250 EPVQGGIFALSWL-DSQKFATVGADATIRVWDVTTSKCVQK 289 >5CXB-B nrPDB Length = 369 Score = 80.6 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 48/258 (18%), Positives = 91/258 (35%), Gaps = 60/258 (23%) Query: 227 EYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARV---------GSLSWN 277 I +++W + G++ A + S + + + ++ H ++ + S++ Sbjct: 157 STIKAISWHRRGDHFATVSPSGQ------RSSVAIHTLSKHLTQIPFRKLNGLAQTASFH 210 Query: 278 S-YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 336 L + I +D++ E G ++ + P G +L G D + +W Sbjct: 211 PLRPLFFVATQRSIRCYDLQKLELVKIVQPG-AKWISSFDVHPGGDNLVVGSYDKRL-LW 268 Query: 337 PSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV 396 + P +T H A++AV + + A + D ++I+ Sbjct: 269 H--DLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFA--DASDDGSLQIF----------- 313 Query: 397 DAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTS----RVLSLTMS 452 H +V P+ + + PT+ V LKGH VL + Sbjct: 314 --HGKV------PNDQL---------------ENPTIVPVKMLKGHKVVNKLGVLDIDWH 350 Query: 453 PDGATVASAAADETLRLW 470 P SA AD T RLW Sbjct: 351 PREPWCVSAGADGTARLW 368 Score = 73.7 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 42/255 (16%), Positives = 88/255 (34%), Gaps = 23/255 (9%) Query: 99 NQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATP 158 N + + P KE WA + E +LR++ + + R + Sbjct: 120 NGKQQANLPPGKEPPGKWARPGTRLEDEGV-LLRITVRSTIKAISWHRRGDHFAT---VS 175 Query: 159 GSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGN-VLAVALDNSVYLWSASSGDIL 217 S +++ I +L + P + + + + VA S+ + +++ Sbjct: 176 PSGQRSSVAIHTLSKHLTQIPFRKLNGLAQTASFHPLRPLFFVATQRSIRCYDLQKLELV 235 Query: 218 QLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ-QQKRLRNMTSHSARVGSLSW 276 +++Q ++ISS G+ L VG+ + D+ + + M H+ + ++ + Sbjct: 236 KIVQ--PGAKWISSFDVHPGGDNLVVGSYDKRLLWHDLDLSNRPYKTMRFHTEAIRAVRF 293 Query: 277 NS---YILSSGSRSGHIHHHDVRVAEHH--------VATLSGHS----QEVCGLRWAPDG 321 + + + S G + +V V L GH V + W P Sbjct: 294 HKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPRE 353 Query: 322 RHLASGGNDNLVNVW 336 S G D +W Sbjct: 354 PWCVSAGADGTARLW 368 Score = 61.3 bits (147), Expect = 8e-10, Method: Composition-based stats. Identities = 41/289 (14%), Positives = 85/289 (29%), Gaps = 62/289 (21%) Query: 263 NMTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHHVAT-LSGHSQEVCGLRWAP 319 H RV S++ + L++G G + ++ + L+G + V +RW P Sbjct: 16 IFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNG-DEAVNTVRWRP 74 Query: 320 DGRHL---ASGGNDNLVNVWPSAP------GEGGWVPLQTFTQH---------------- 354 A+ G D + + P+ P + L H Sbjct: 75 TKDTFILAAAAGEDIFLMI-PTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPGKEP 133 Query: 355 ----------------------QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC---S 389 + +KA++W + + I + + Sbjct: 134 PGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRSSVAIHTLSKHLT 193 Query: 390 GACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSL 449 ++ +Q S + P Q + + + V ++ + S Sbjct: 194 QIPFRKLNGLAQTAS--FHPLRPLFFVA---TQRSIRCYDLQKLELVKIVQPGAKWISSF 248 Query: 450 TMSPDGATVASAAADETLRLWRCFELDP-ARRREREKASAAKSSLIHQG 497 + P G + + D+ L LW +L + R A ++ H+G Sbjct: 249 DVHPGGDNLVVGSYDKRL-LWHDLDLSNRPYKTMRFHTEAIRAVRFHKG 296 Score = 51.3 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 13/53 (24%), Positives = 21/53 (39%) Query: 437 AELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAA 489 +GH RV S+ + P G +A+ D T+R+W + A Sbjct: 15 TIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAV 67 >5A9Q-2 nrPDB Length = 326 Score = 79.8 bits (195), Expect = 3e-15, Method: Composition-based stats. Identities = 28/194 (14%), Positives = 57/194 (29%), Gaps = 14/194 (7%) Query: 294 DVRVAEHHVATLSGHSQEVCGLRWAPDGRH--------LASGGNDNLVNVWPSAPGEGGW 345 DV ++ H V G+ W+P+ R + D + ++ Sbjct: 57 DVEGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLF--TSDLQDK 114 Query: 346 VPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSI 405 + H + + + P + +A+ + D RIWN+ G + HS S+ Sbjct: 115 NEYKVLEGHTDFINGLVFDPKEGQEIASV--SDDHTCRIWNL-EGVQTAHFVLHSPGMSV 171 Query: 406 LWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADE 465 W P + + + + L+ ++S A A Sbjct: 172 CWHPEETFKLMVA-EKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGN 230 Query: 466 TLRLWRCFELDPAR 479 +W + Sbjct: 231 DWLIWDITRSSYPQ 244 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 36/203 (17%), Positives = 73/203 (35%), Gaps = 19/203 (9%) Query: 179 PEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK-E 237 PE R D ++ + + A D + L+++ D + +E ++I+ + + E Sbjct: 82 PETRLDSLPPVIKFCT-----SAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPKE 136 Query: 238 GNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY---ILSSGSRSGHIHHHD 294 G +A + ++W+++ + + HS S+ W+ L ++G I +D Sbjct: 137 GQEIASVSDDHTCRIWNLE-GVQTAHFVLHSPG-MSVCWHPEETFKLMVAEKNGTIRFYD 194 Query: 295 VRVAEHHVATLSGHSQEVCGLRWAPDGRHLA--SGGNDNLVNVWPSAPGEGGWVPLQTFT 352 + +A+ + +L + W GND L +W Sbjct: 195 L-LAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWL--IWDITRSSYPQNKRPV-- 249 Query: 353 QHQGAVKAVAWCPWQSNVLATGG 375 H W N+ AT G Sbjct: 250 -HMDRACLFRWSTISENLFATTG 271 Score = 58.3 bits (139), Expect = 7e-09, Method: Composition-based stats. Identities = 33/197 (16%), Positives = 69/197 (35%), Gaps = 24/197 (12%) Query: 309 SQEVCGLRWAP-----DGRHLASGGNDNLV---NVWPSAPGEGGWVPLQTFT--QHQGAV 358 V + + P G +A GGN+ +V + + + +T H V Sbjct: 16 EDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVRV 75 Query: 359 KAVAWCPWQS-----NVLATGGGTSDRHIRIW--NVCSGACLSAVDAHSQ-VCSILWSP- 409 +AW P V+ +D IR++ ++ ++ H+ + +++ P Sbjct: 76 DGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPK 135 Query: 410 HYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGAT-VASAAADETLR 468 +E+ S + IW + A H+ + S+ P+ + A + T+R Sbjct: 136 EGQEIASVSD--DHTCRIWNLE-GVQTAHFVLHSPGM-SVCWHPEETFKLMVAEKNGTIR 191 Query: 469 LWRCFELDPARRREREK 485 + E E+ Sbjct: 192 FYDLLAQQAILSLESEQ 208 >6BX3-B nrPDB Length = 412 Score = 77.9 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 38/228 (16%), Positives = 79/228 (34%), Gaps = 23/228 (10%) Query: 273 SLSWNS--YILSSGSRSGHIHHHD---VRVAEHHVATLSGHSQEVCGLRWAPDGRHLASG 327 L ++ L+ G +G + +D R L H + + + W+PDGR L + Sbjct: 30 CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS 89 Query: 328 GNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVL----------ATGGGT 377 D + +W + ++ + W + + + Sbjct: 90 SRDWSIKLWDLSKPSKPLKEIR----FDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFS 145 Query: 378 SDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTM---A 434 +D + + LS+ H V + +I G ++ L +K+ ++ Sbjct: 146 NDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIV-GTSKGWLDFYKFHSLYQTE 204 Query: 435 KVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRRE 482 + LK +S + L +S +G +A +D T+R + D E Sbjct: 205 CIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVE 252 Score = 76.7 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 44/329 (13%), Positives = 99/329 (30%), Gaps = 72/329 (21%) Query: 172 PDRILDAPEIRNDYYLNLVDWS-SGNVLA-VALDNSVYLWSASSGDILQL--LQMEQPGE 227 P+++ I N + +S G+ LA + ++ ++ + + + + Sbjct: 15 PEKLTHT--IENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVR 72 Query: 228 YISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW----------- 276 I+S+AW +G L + ++LWD+ + + + + W Sbjct: 73 PITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 132 Query: 277 ------------------------NSYILSSGSRSGHIHHHDVRV--------------- 297 + LSS G++ V Sbjct: 133 IFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWL 192 Query: 298 ---------AEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPL 348 + +L S + L + +G LA +D + + + + Sbjct: 193 DFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVE 252 Query: 349 QTFTQ-HQGAVKAVAW------CPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ 401 T +Q + + W ++A+ G+S + IW SG + ++ + Sbjct: 253 LTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEE 312 Query: 402 VCSILWSPHYKELISGHGFAQNQLVIWKY 430 + Y I +GF + +W Sbjct: 313 ELIDINWDFYSMSIVSNGFESGNVYVWSV 341 Score = 61.7 bits (148), Expect = 6e-10, Method: Composition-based stats. Identities = 20/97 (20%), Positives = 38/97 (39%), Gaps = 6/97 (6%) Query: 391 ACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAE----LKGHTSRV 446 ++ + + +SP L G A LVI+ T + L H + Sbjct: 17 KLTHTIENPLRTECLQFSPCGDYL--ALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI 74 Query: 447 LSLTMSPDGATVASAAADETLRLWRCFELDPARRRER 483 S+ SPDG + +++ D +++LW + + R Sbjct: 75 TSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIR 111 >5A9Q-0 nrPDB Length = 380 Score = 77.5 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 31/172 (18%), Positives = 76/172 (44%), Gaps = 14/172 (8%) Query: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 252 ++ ++ V D + L+ A + ++ + + +V +++ L V + ++++ Sbjct: 140 NNPEIVTVGEDGRINLFRADHKEAVRTID-NADSSTLHAVTFLRTPEILTVNSI-GQLKI 197 Query: 253 WDVQQQ----KRLRNMTSHSARVGSLSWNS---YILSSGSRSGHIHHHDVRVAEHHVATL 305 WD +QQ ++ ++T + + + +++++G + G + DVR V+ L Sbjct: 198 WDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLL 257 Query: 306 SGHSQEVCGLRWAPDGR-HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG 356 H E+ + + P HL + D + W ++ VP ++ HQG Sbjct: 258 KAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTD----VPEKSSLFHQG 305 Score = 76.7 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 43/295 (14%), Positives = 85/295 (28%), Gaps = 55/295 (18%) Query: 241 LAVGTSSAE---VQLWDVQQQKRLRNMTS------------HSARVGSLSW-NSYILSSG 284 A G+ E + LW + L + H V L + + + + Sbjct: 32 FATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQERIVAA 91 Query: 285 SRSGHIHHH------DVRVAEHHVATLSGHSQEVC-------GLRWAPDGRHLASGGNDN 331 S +G + T H+ + + + G D Sbjct: 92 SSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVTVGEDG 151 Query: 332 LVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG- 390 +N++ + E + AV + +L ++IW+ Sbjct: 152 RINLFRADHKEAVRTIDNADSSTLHAVTFLR----TPEILTVNSI---GQLKIWDFRQQG 204 Query: 391 ---ACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA-KVAELKGHTSR 445 + + ++ + + P+ + ++ G L IW V+ LK H + Sbjct: 205 NEPSQILSLTGDRVPLHCVDRHPNQQHVV-ATGGQDGMLSIWDVRQGTMPVSLLKAHEAE 263 Query: 446 VLSLTMSPDGA-TVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR 499 + + P + + + D +L W KSSL HQG R Sbjct: 264 MWEVHFHPSNPEHLFTCSEDGSLWHWDAS-----------TDVPEKSSLFHQGGR 307 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 44/291 (15%), Positives = 87/291 (29%), Gaps = 36/291 (12%) Query: 193 SSGNVLAVALDNS---VYLWSA-----------SSGDILQLLQMEQPGEYISSVAWIKEG 238 ++ + DN + LWS GD L + G+ + + + + Sbjct: 28 TAETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGD-VMDLQFFDQE 86 Query: 239 NYLAVGTS-----------SAEVQLWDVQQQKRLRNMTSH----SARVGSLSWNSYILSS 283 +A ++ + + + SA + N+ + + Sbjct: 87 RIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVT 146 Query: 284 GSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEG 343 G I+ E + S + + + L + +W Sbjct: 147 VGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSI-GQLKIWDFRQQGN 205 Query: 344 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGA-CLSAVDAHS-Q 401 + + T + + V P Q +V+ATGG D + IW+V G +S + AH + Sbjct: 206 EPSQILSLTGDRVPLHCVDRHPNQQHVVATGG--QDGMLSIWDVRQGTMPVSLLKAHEAE 263 Query: 402 VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMS 452 + + + P E + L W T H S +S Sbjct: 264 MWEVHFHPSNPEHLF-TCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLS 313 >3ACP-A nrPDB Length = 417 Score = 77.1 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 30/274 (10%), Positives = 83/274 (30%), Gaps = 37/274 (13%) Query: 196 NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV 255 + + + + ++ ++ + + + I+ + + G L + ++++W V Sbjct: 108 RFILGTTEGDIKVLDSNF-NLQREID-QAHVSEITKLKFFPSGEALISSSQDMQLKIWSV 165 Query: 256 QQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATL---SGHSQ 310 + R + H A V ++ + S S G I + + T Sbjct: 166 KDGSNPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGT-TIHTFNRKENPHD 224 Query: 311 EVCGLR---------------------WAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQ 349 V + + G+++ +G ++ V E Sbjct: 225 GVNSIALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPS 284 Query: 350 TFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGAC---LSAVDAHSQVCSIL 406 FT + +N G + + W++ S C ++ + + ++ Sbjct: 285 KFT-----CSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVY 339 Query: 407 WSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK 440 ++ + SG + +I + E + Sbjct: 340 FAAGALFVSSGFDTSIKLDIISDPESERPAIEFE 373 Score = 66.7 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 29/112 (25%), Positives = 47/112 (41%), Gaps = 3/112 (2%) Query: 376 GTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA 434 GT++ I++ + AH S++ + + P + LIS QL IW + Sbjct: 112 GTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSS--QDMQLKIWSVKDGS 169 Query: 435 KVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKA 486 L GH + V + + G V SA+ D T+RLW C R++ Sbjct: 170 NPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKEN 221 Score = 53.2 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 31/79 (39%) Query: 419 GFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPA 478 G + + + + + H S + L P G + S++ D L++W + Sbjct: 112 GTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNP 171 Query: 479 RRREREKASAAKSSLIHQG 497 R +A+ ++I +G Sbjct: 172 RTLIGHRATVTDIAIIDRG 190 >2P9P-C nrPDB Length = 372 Score = 75.6 bits (184), Expect = 5e-14, Method: Composition-based stats. Identities = 43/260 (16%), Positives = 95/260 (36%), Gaps = 31/260 (11%) Query: 227 EYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQK--RLRNMTSHSARVGSLSW--NSYILS 282 E IS AW K+ +A+ ++ EV +++ K ++ + H+ +V + W +S + Sbjct: 9 EPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIV 68 Query: 283 SGSRSGHIHHHDV--RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAP 340 + + + + R + + L + +RWAP+ + A G ++++ Sbjct: 69 TCGTDRNAYVWTLKGRTWKPTLVILRINRAA-RCVRWAPNEKKFAVGSGSRVISICYFEQ 127 Query: 341 GEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS------ 394 WV + V ++ W P N + G+ D RI++ Sbjct: 128 ENDWWVCKHIKKPIRSTVLSLDWHP---NSVLLAAGSCDFKCRIFSAYIKEVEERPAPTP 184 Query: 395 ----------AVDAHS---QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKG 441 ++ S V + +S + + + + + VA L Sbjct: 185 WGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVS--HDSTVCLADADKKMAVATLAS 242 Query: 442 HTSRVLSLTMSPDGATVASA 461 T +L++T + + VA+ Sbjct: 243 ETLPLLAVTFITESSLVAAG 262 Score = 74.8 bits (182), Expect = 7e-14, Method: Composition-based stats. Identities = 42/362 (11%), Positives = 104/362 (28%), Gaps = 81/362 (22%) Query: 187 LNLVDWSSG--NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVG 244 ++ W+ + ++ V+++ S +Q+ ++++ ++ V W + N + Sbjct: 11 ISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVTC 70 Query: 245 TSSAEVQLWDVQ--QQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHH-------- 292 + +W ++ K + + + W N + GS S I Sbjct: 71 GTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQEND 130 Query: 293 -HDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTF 351 + + + + V L W P+ LA+G D ++ + E P T Sbjct: 131 WWVCKHIKKPIRST------VLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTP 184 Query: 352 TQHQ--------------GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVD 397 + G V V + S V + D + + + ++ + Sbjct: 185 WGSKMPFGELMFESSSSCGWVHGVCFSANGSRV---AWVSHDSTVCLADADKKMAVATLA 241 Query: 398 AHS-QVCSILWSPHYKELISGHGFAQNQLVI------------WKYPTMAKVAELKG--- 441 + + + ++ + + +GH P + L Sbjct: 242 SETLPLLAVTFITESSLVAAGHDCFPVLFTYDSAAGKLSFGGRLDVPKQSSQRGLTARER 301 Query: 442 -----------------------HTSRVLSLTMSPDGAT----VASAAADETLRLWRCFE 474 H + V +++ G + D + +W Sbjct: 302 FQNLDKKASSEGSAAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVRS 361 Query: 475 LD 476 L+ Sbjct: 362 LE 363 Score = 74.8 bits (182), Expect = 8e-14, Method: Composition-based stats. Identities = 34/177 (19%), Positives = 69/177 (38%), Gaps = 10/177 (5%) Query: 310 QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 369 + + W D +A N++ V+++ + + WV + +H G V V W P + Sbjct: 9 EPISCHAWNKDRTQIAICPNNHEVHIYEKSGNK--WVQVHELKEHNGQVTGVDWAPDSNR 66 Query: 370 VLATGGGTSDRHIRIWNVCSGA---CLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLV 426 ++ G DR+ +W + L + + + W+P+ K+ G G + Sbjct: 67 IVTCGT---DRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISIC 123 Query: 427 IWKYPT--MAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRR 481 ++ K S VLSL P+ +A+ + D R++ + + R Sbjct: 124 YFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERP 180 Score = 69.8 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 44/223 (19%), Positives = 74/223 (33%), Gaps = 29/223 (13%) Query: 269 ARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEH-HVATLSGHSQEVCGLRWAPDGRHLA 325 + +WN ++ + +H ++ + V L H+ +V G+ WAPD + Sbjct: 9 EPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIV 68 Query: 326 SGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW 385 + G D VW W P + A + V W P A G G+ I + Sbjct: 69 TCGTDRNAYVW--TLKGRTWKPTLVILRINRAARCVRWAP-NEKKFAVGSGSRVISICYF 125 Query: 386 NVCSG---ACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVI--------------- 427 + S V S+ W P+ ++ G + I Sbjct: 126 EQENDWWVCKHIKKPIRSTVLSLDWHPNS--VLLAAGSCDFKCRIFSAYIKEVEERPAPT 183 Query: 428 -W--KYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETL 467 W K P + E V + S +G+ VA + D T+ Sbjct: 184 PWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTV 226 Score = 39.0 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 27/224 (12%), Positives = 63/224 (28%), Gaps = 63/224 (28%) Query: 190 VDWSSGNVL--AVALDNSVYLWSASSGDILQ----------------LLQMEQPGEYISS 231 +DW +VL A + D ++SA ++ + + + ++ Sbjct: 148 LDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHG 207 Query: 232 VAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW-NSYILSSGSRSGHI 290 V + G+ +A + + V L D ++ + + S + + ++++ L + Sbjct: 208 VCFSANGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLAVTFITESSLVAAGHDCFP 267 Query: 291 HHHDVRVAEHHV-----------------------------ATLSG-----------HSQ 310 A + A+ G H Sbjct: 268 VLFTYDSAAGKLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGSAAAGAGLDSLHKN 327 Query: 311 EVCGLRWAPDG----RHLASGGNDNLVNVWPSAPGEGGWVPLQT 350 V + G + G D +++W E L+ Sbjct: 328 SVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVRSLESALKDLKI 371 >3JB9-S nrPDB Length = 488 Score = 74.4 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 52/383 (13%), Positives = 125/383 (32%), Gaps = 44/383 (11%) Query: 110 KEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTC---- 165 +E ++ N+ + ++ + + R V + + ++T Sbjct: 126 REALAKFSDNIGTVSSKTIEVQEVEMGESDDQLKTSLRSTVEKTFQELSSKRKRTKLQPK 185 Query: 166 --------RYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDIL 217 + + + P IL+ E + +S VL + D + L S L Sbjct: 186 WATDDAVSQLLQATPSTILENLETESTTSFFPSPENSSFVLCLHKDELLCL-DIQSNSTL 244 Query: 218 QLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSAR------- 270 ++ + + W+ +AV T+ + +++ Sbjct: 245 KIFEG-----SALACCWLTSSK-IAVATAD-AISIFEFPVSSSGLQSVGEPTSSIPIDEK 297 Query: 271 VGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGG 328 V L + L + S + ++ +++ +Q + L PDG +G Sbjct: 298 VNFLQAHPSGEYLLAASNEK-CYIFSLKSQVYNITV----AQHITSLAVHPDGNLFVAGL 352 Query: 329 NDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC 388 + + + ++ G L F H VK + + ++ T D I IW++ Sbjct: 353 ENGELRFFETSSGNE----LTKFGPHSSPVKTLQFGENGYWLVVTTN--DDSDIFIWDLR 406 Query: 389 SGACLSAVDAHSQVCSILWSPHYKELISGHGFAQN-QLVIWKYPTMAKVAELKGHTSRVL 447 + + ++V ++ + L+S G + + + +++ H S + Sbjct: 407 KSELVQKIPLQTKVAAVSLDITSQLLVSSDGETLYVHIYVKSSKSWRCMSQT--HVSSIS 464 Query: 448 SLTMSPDGA-TVASAAADETLRL 469 +L + + S + LRL Sbjct: 465 NLVWLNELHQLLFSTSNGAILRL 487 Score = 42.1 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 24/204 (11%), Positives = 55/204 (26%), Gaps = 31/204 (15%) Query: 295 VRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQH 354 E+ L H E+ L + + ++ + W+ Sbjct: 216 FPSPENSSFVLCLHKDELLCLDIQSNS----------TLKIFEGSALACCWLTSSKIAVA 265 Query: 355 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKEL 414 ++ P S+ L + G S++ +V + P + L Sbjct: 266 TADAISIFEFPVSSSGLQSV---------------GEPTSSIPIDEKVNFLQAHPSGEYL 310 Query: 415 ISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474 ++ + I+ + + H + SL + PDG + + LR + Sbjct: 311 LAAS---NEKCYIFSLKSQVYNITVAQH---ITSLAVHPDGNLFVAGLENGELRFFETSS 364 Query: 475 LDPARRREREKASAAKSSLIHQGI 498 + + + G Sbjct: 365 GNELTKFGPHSSPVKTLQFGENGY 388 >5MC6-j nrPDB Length = 397 Score = 72.1 bits (175), Expect = 6e-13, Method: Composition-based stats. Identities = 47/342 (13%), Positives = 103/342 (30%), Gaps = 67/342 (19%) Query: 216 ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ------QQKRLRNMTSHSA 269 I + I SV+ + + +++WD + + + + H + Sbjct: 6 IATANAGKAHDADIFSVSACNS--FTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKS 63 Query: 270 RVGSL---------SWNSYILSSGSRSGHIHHHDVRVAEHHVAT-----------LSGHS 309 + + ++ ++++ S SG + + + + + HS Sbjct: 64 GLHHVDVLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHS 123 Query: 310 QEVCGLRWAPDGRHLAS---GGND--NLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 L+W L S D +W P L ++ Sbjct: 124 FW--ALKWGASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVES 181 Query: 365 PWQSNVLAT----------GGGTSDRHIRIWNVCSGACLSAVDA-HS------QVCSILW 407 P + AT G ++ ++I + + L ++ HS + S+ + Sbjct: 182 PMTPSQFATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKF 241 Query: 408 SPHYKELISGHGFAQ-NQLVIWKYPTMAKVAELK-------------GHTSRVLSLTMSP 453 SP L H + +++ ++ L H+S V+SL+ + Sbjct: 242 SPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFND 301 Query: 454 DGATVASAAADETLRLWRCFELDPARRRERE-KASAAKSSLI 494 G T+ SA D LR W + + ++ Sbjct: 302 SGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDIEIEEDIL 343 Score = 51.3 bits (121), Expect = 9e-07, Method: Composition-based stats. Identities = 20/110 (18%), Positives = 43/110 (39%), Gaps = 16/110 (14%) Query: 178 APEIRNDYYLNLVDWS-SGNVLAVALD----NSVYLWSASSGDIL-----------QLLQ 221 I N + V +S G++LA+A D + L+ G+ + L Sbjct: 227 HSMINNSNSIRSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLG 286 Query: 222 MEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARV 271 ++ S+++ G L +++ WDV+ ++R+ + H + Sbjct: 287 EFAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDI 336 >6CHG-D nrPDB Length = 439 Score = 70.6 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 59/329 (17%), Positives = 112/329 (34%), Gaps = 44/329 (13%) Query: 172 PDRILDAPEIRNDYYLNLVDWSS-GNVLAVA-LDNSVYLWSASSGDILQLLQME--QPGE 227 P+++ E+ V +S G+ LAV + ++ ++ S + +L Sbjct: 17 PEKLTHTLEV--PVAAVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTR 74 Query: 228 YISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKR---LRNMTSHSARVGSLSWNSYILSSG 284 + SV W +G YL +LWD+ Q + + WN I++ Sbjct: 75 SVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWNVCIVTVV 134 Query: 285 SRSGH--IHHHDVRVAEHHVATLS------GHSQEVCGLRWAPD-GRHLASGGNDNLVNV 335 + D + A H L GH P + +G + +N Sbjct: 135 EEPTAYVLTLTDRQNAFHCFPLLEQDQDISGH-GYTLVACPHPTIESIIITGTSKGWINA 193 Query: 336 WPSAPGEGGWVPLQTFTQHQ---GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV----- 387 + G ++ + + +K + P + + G DR IR + + Sbjct: 194 FQLDLESGFEDKIRCCYEEKIANANIKQIIISPSGTRIAINGS---DRTIRQYQLIVEDN 250 Query: 388 ----CSGACLSAVDAHS--------QVCSILWSPHYKELI--SGHGFAQNQLVIWKYPTM 433 S +S H Q +I +S H E + S HG + + L +W+ + Sbjct: 251 ESEGGSSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSSG 310 Query: 434 AKVAELKGHTSRVLSLTMSPDGATVASAA 462 + V L+G +L + + +AS Sbjct: 311 SLVRVLEGADEELLDIDWNFYSMRIASNG 339 Score = 69.4 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 43/304 (14%), Positives = 89/304 (29%), Gaps = 54/304 (17%) Query: 228 YISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSA----RVGSLSW--NSYIL 281 V + G+YLAVG S+ + ++D+ K + + +HS V S+ W + L Sbjct: 29 AAVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSNDGRYL 88 Query: 282 SSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPG 341 S R + D+ + + + + V Sbjct: 89 WSSGRDWYAKLWDMTQPTKCFQQYKF-DGPLWSCHVVRWNVCIVTVVEEPTAYVLTLTDR 147 Query: 342 EGGWVPL------QTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW------NVCS 389 + + Q + H G P +++ TG + W ++ S Sbjct: 148 QNAFHCFPLLEQDQDISGH-GYTLVACPHPTIESIIITG------TSKGWINAFQLDLES 200 Query: 390 G------ACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKY----------PTM 433 G C A++ + I+ SP + + + ++ + Sbjct: 201 GFEDKIRCCYEEKIANANIKQIIISPSGTRI--AINGSDRTIRQYQLIVEDNESEGGSSH 258 Query: 434 AKVAELKG-HTSRVLSLTMSP------DGATVAS---AAADETLRLWRCFELDPARRRER 483 + EL+ + + L + G + + ++ L LW R E Sbjct: 259 SVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSSGSLVRVLEG 318 Query: 484 EKAS 487 Sbjct: 319 ADEE 322 Score = 68.7 bits (166), Expect = 6e-12, Method: Composition-based stats. Identities = 41/241 (17%), Positives = 83/241 (34%), Gaps = 29/241 (12%) Query: 259 KRLRNMTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEH--HVATLSG-HSQEVC 313 K + A V + ++ L+ G +G I +D+ + + T SG H++ V Sbjct: 19 KLTHTLEVPVAAV-CVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQ 77 Query: 314 GLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLAT 373 + W+ DGR+L S G D +W + + F + V W + Sbjct: 78 SVCWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQQYK-FDGPLWSCHVVRWN------VCI 130 Query: 374 GGGTSDRHIRIWNVCSGA----CLSAVDAHSQVCS----ILWSPHYK-ELISGHGFAQNQ 424 + + + C ++ + ++ PH E I G ++ Sbjct: 131 VTVVEEPTAYVLTLTDRQNAFHCFPLLEQDQDISGHGYTLVACPHPTIESIIITGTSKGW 190 Query: 425 LVIW--KYPTM-----AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDP 477 + + + E K + + + +SP G +A +D T+R ++ D Sbjct: 191 INAFQLDLESGFEDKIRCCYEEKIANANIKQIIISPSGTRIAINGSDRTIRQYQLIVEDN 250 Query: 478 A 478 Sbjct: 251 E 251 >5K19-A nrPDB Length = 569 Score = 66.7 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 27/201 (13%), Positives = 58/201 (28%), Gaps = 35/201 (17%) Query: 233 AWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHI 290 A+ +G +LA + +++++ + M S+ + + W + + +G + Sbjct: 227 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 286 Query: 291 HHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHL-------ASGGNDNLVNVWPSAPGEG 343 V +A GH V + + P + SG + Sbjct: 287 TVWSF-VDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGS-------------DE 332 Query: 344 GWVPLQTFTQHQGAVKAVAWCPWQSN-------VLATGGGTSDRHIRIWNVCSG-----A 391 + L F + + S G D + +W++ Sbjct: 333 DFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQ 392 Query: 392 CLSAVDAHSQVCSILWSPHYK 412 LS H+ V + P Sbjct: 393 PLSRARTHTNVMNATSPPAGS 413 Score = 62.1 bits (149), Expect = 5e-10, Method: Composition-based stats. Identities = 40/211 (18%), Positives = 71/211 (33%), Gaps = 27/211 (12%) Query: 186 YLNLVDWS-SGNVLAV-ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAV 243 LN +S G LA + D + +++ S ++ ++ G + V W +G Y+ Sbjct: 222 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGG--LLCVCWSPDGKYIVT 279 Query: 244 GTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILS---------SGSRSGHIHHHD 294 G V +W + + H + V ++++ Y S SGS D Sbjct: 280 GGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDE------D 333 Query: 295 VRVAEHHVATLSGHSQEVCGLRWAPDGR------HLASGGNDNLVNVWPSAPGEG-GWVP 347 + H + +Q R + D R S G D + +W P Sbjct: 334 FQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQP 393 Query: 348 LQTFTQHQGAVKAVA-WCPWQSNVLATGGGT 377 L H + A + N + T G + Sbjct: 394 LSRARTHTNVMNATSPPAGSNGNSVTTPGNS 424 Score = 59.0 bits (141), Expect = 5e-09, Method: Composition-based stats. Identities = 36/238 (15%), Positives = 67/238 (28%), Gaps = 62/238 (26%) Query: 173 DRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSV 232 ++ + + + + V W G+ S++L + SSG++ G Sbjct: 138 SKLFNEERLIDKSRVTCVKWVPGS-------ESLFLVAHSSGNMYLYNVEHTCGTTAPHY 190 Query: 233 AWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHH 292 +K+G AV T S S + Sbjct: 191 QLLKQGESFAVHTCK-----------------------------------SKSTRNPLLK 215 Query: 293 HDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFT 352 V + ++PDG+ LA D + V+ E F Sbjct: 216 WTVG------------EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFG 263 Query: 353 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSP 409 + V W P ++ G D + +W+ ++ H S V + + P Sbjct: 264 G----LLCVCWSPDGKYIV---TGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDP 314 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 22/171 (12%), Positives = 51/171 (29%), Gaps = 35/171 (20%) Query: 355 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVD----------------- 397 + V V W P ++ + ++ ++NV C + Sbjct: 149 KSRVTCVKWVPGSESLFLVAHSS--GNMYLYNVEH-TCGTTAPHYQLLKQGESFAVHTCK 205 Query: 398 -------------AHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTS 444 + +SP K L L ++ + ++ +K + Sbjct: 206 SKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVS--QDGFLRVFNFDSVELHGTMKSYFG 263 Query: 445 RVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIH 495 +L + SPDG + + D+ + +W + R K+ + + Sbjct: 264 GLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDP 314 >5AMS-A nrPDB Length = 431 Score = 65.2 bits (157), Expect = 7e-11, Method: Composition-based stats. Identities = 46/294 (15%), Positives = 97/294 (32%), Gaps = 33/294 (11%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256 V DN +LW++ S + GE + S ++ EG +L S +V + Q Sbjct: 80 VCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQ 139 Query: 257 QQKRLRNMTSHSARVGSLSW---NSYI---LSSGSRSGHIHHHDVRVAEHHVATLSG--- 307 + + S V + W + I + G+ G + + + + + L Sbjct: 140 KGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFV 199 Query: 308 HSQEVCGLRW-APDGR----HLASGGNDNLVNVWPSAPGEGGWVPLQT-FTQHQGAVKAV 361 H Q+ + D L + D+ + W G+ + Q + ++ Sbjct: 200 HQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISL 259 Query: 362 AWCP---WQSNVLATGGGTSDRHIRIWNVCSGACLSAV-----------DAHSQVCSILW 407 + P + N G+++ + + N +G + + + + + SI W Sbjct: 260 SLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISW 319 Query: 408 SPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASA 461 S K + G +++++ + V L D AS Sbjct: 320 S--SKFSLMAIGLVCGEILLYDTSAWRVRHKFVL-EDSVTKLMFDND-DLFASC 369 Score = 52.1 bits (123), Expect = 6e-07, Method: Composition-based stats. Identities = 29/192 (15%), Positives = 63/192 (32%), Gaps = 17/192 (8%) Query: 294 DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ 353 +V ++ + + H+ V + P+ + +GG DNL ++W T T Sbjct: 50 EVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW--TSHSQPPKFAGTLTG 107 Query: 354 HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYK 412 + +V + ++ + L T + + + G + + +V I+W + Sbjct: 108 YGESVISCSFT-SEGGFLVTADMS--GKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHP 164 Query: 413 ELISGHGFAQNQLVIWKYPTMAKVAELKG------HTSRVLSLTMSPDGA-----TVASA 461 + F +W Y + L+ H + + Sbjct: 165 TIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTC 224 Query: 462 AADETLRLWRCF 473 + D T+ W CF Sbjct: 225 SLDSTIVAWNCF 236 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 31/190 (16%), Positives = 73/190 (38%), Gaps = 31/190 (16%) Query: 193 SSGNVLAVALDNSVYLWSASSGD---ILQLLQMEQPGEYISSVAWIKE----GNY--LAV 243 ++ ++ +LD+++ W+ +G + +++ S++ E GN +A Sbjct: 217 NTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVAC 276 Query: 244 GTSSAEVQLWDVQQQKRLRNMTS----------HSARVGSLSWNSY--ILSSGSRSGHIH 291 G+++ + + + + ++++ A + S+SW+S +++ G G I Sbjct: 277 GSNNGLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEIL 336 Query: 292 HHDVRVAE-HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQT 350 +D H L V L + + AS N V + + G+ +V + Sbjct: 337 LYDTSAWRVRHKFVLE---DSVTKLMF-DNDDLFASCIN-GKVYQFNARTGQEKFVCV-- 389 Query: 351 FTQHQGAVKA 360 H V Sbjct: 390 --GHNMGVLD 397 >3DWL-C nrPDB Length = 377 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 40/229 (17%), Positives = 77/229 (33%), Gaps = 27/229 (11%) Query: 275 SWNSYI--LSSGSRSGHIHHHD-VRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDN 331 ++NS + + + + ++ H T S H + V + WAP + + D Sbjct: 18 AFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDR 77 Query: 332 LVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG- 390 V+ P +G W + A V W P + A G G + + + Sbjct: 78 NAYVYEKRP-DGTWKQTLVLLRLNRAATFVRWSPNEDK-FAVGSGARVISVCYFEQENDW 135 Query: 391 --ACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLV--------------IW--KYPT 432 + S + S+ W P+ L +G + ++ +W + P Sbjct: 136 WVSKHLKRPLRSTILSLDWHPNNVLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPF 195 Query: 433 MAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRR 481 AE V ++ SP G +A A D ++ + + P + Sbjct: 196 NTVCAEYPS-GGWVHAVGFSPSGNALAYAGHDSSVTI--AYPSAPEQPP 241 Score = 59.0 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 31/176 (17%), Positives = 62/176 (35%), Gaps = 17/176 (9%) Query: 316 RWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGG 375 + + N V ++ GW +TF+ H V V W P + ++ Sbjct: 18 AFNSQRTEFVTTTATNQVELYEQDGN--GWKHARTFSDHDKIVTCVDWAPKSNRIVTC-- 73 Query: 376 GTSDRHIRIW----NVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYP 431 + DR+ ++ + L + + + WSP+ + G G + ++ Sbjct: 74 -SQDRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISVCYFEQE 132 Query: 432 TMAKVAELKGHTSR-----VLSLTMSPDGATVASAAADETLRLWRCFELDPARRRE 482 V++ H R +LSL P+ +A+ AD + + D + E Sbjct: 133 NDWWVSK---HLKRPLRSTILSLDWHPNNVLLAAGCADRKAYVLSAYVRDVDAKPE 185 >5TF2-A nrPDB Length = 407 Score = 62.5 bits (150), Expect = 4e-10, Method: Composition-based stats. Identities = 37/252 (14%), Positives = 71/252 (28%), Gaps = 45/252 (17%) Query: 232 VAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY-ILSSGSRSGHI 290 V + + LA G + V++W V +++ +H + L+ L + R Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGRDLKA 237 Query: 291 HHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQT 350 Q V L W +G +S + P + + L T Sbjct: 238 SVWQK-------------DQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFT 284 Query: 351 FTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVD-AHSQVCSILWSP 409 P + ++ W+ + L H V + S Sbjct: 285 VQ-----------IPHKRLRQPPP-----CYLTAWDGSNFLPLRTKSCGHEVVSCLDVSE 328 Query: 410 HYKELISGHGFAQNQLVIWKYPTMAKVAEL-KGHTSRVLSLTMSPD-----------GAT 457 L G G + I+ ++ + + + H V + P+ Sbjct: 329 SGTFL--GLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPELLGSHETA 386 Query: 458 VASAAADETLRL 469 + S A D +L Sbjct: 387 LFSVAVDSRCQL 398 Score = 59.8 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 18/85 (21%), Positives = 35/85 (41%), Gaps = 2/85 (2%) Query: 387 VCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRV 446 V + + + + ++ H L+ G + +WK P++ KV E K H + Sbjct: 159 VENLQAVQTDFSSDPLQKVVCFNHDNTLL-ATGGTDGYVRVWKVPSLEKVLEFKAHEGEI 217 Query: 447 LSLTMSPDGATVASAAADETLRLWR 471 L + PDG + + D +W+ Sbjct: 218 EDLALGPDGK-LVTVGRDLKASVWQ 241 Score = 40.5 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 22/107 (20%), Positives = 41/107 (38%), Gaps = 18/107 (16%) Query: 355 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKE 413 ++ V + +LATGG +D ++R+W V S + AH ++ + P K Sbjct: 171 SDPLQKVVCFNHDNTLLATGG--TDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKL 228 Query: 414 LISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVAS 460 + G + +W+ + V L +G T +S Sbjct: 229 VTVG---RDLKASVWQKDQL------------VTQLHWQENGPTFSS 260 Score = 37.5 bits (85), Expect = 0.014, Method: Composition-based stats. Identities = 8/47 (17%), Positives = 18/47 (38%) Query: 451 MSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 + D +A+ D +R+W+ L+ + + +L G Sbjct: 180 FNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDG 226 >5WLC-LW nrPDB Length = 554 Score = 58.6 bits (140), Expect = 6e-09, Method: Composition-based stats. Identities = 33/221 (14%), Positives = 78/221 (35%), Gaps = 16/221 (7%) Query: 279 YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 ++L +G R GH+ D R + ++ + + ++ A ++ Sbjct: 124 HLLITG-RKGHVASMDWRKGQLRAELFL--NETCHSATYLQNEQYFAVAQK-KYTFIYDH 179 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 E + +H + + P+ +L T G T ++ +V +G +S + Sbjct: 180 EGTELHRLKQHIEARH------LDFLPY-HYLLVTAGET--GWLKYHDVSTGQLVSELRT 230 Query: 399 HS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGAT 457 + ++ +P + GH + + +W + +L V S+ + G Sbjct: 231 KAGPTMAMAQNPWNAVMHLGH--SNGTVSLWSPSMPEPLVKLLSARGPVNSIAIDRSGYY 288 Query: 458 VASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGI 498 +A+ AD ++++W E S+ G+ Sbjct: 289 MATTGADRSMKIWDIRNFKQLHSVESLPTPGTNVSISDTGL 329 Score = 52.5 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 20/142 (14%), Positives = 50/142 (35%), Gaps = 7/142 (4%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256 ++ + S+G ++ ++ ++A + +G S+ V LW Sbjct: 205 LVTAGETGWLKYHDVSTGQLVS--ELRTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWSPS 262 Query: 257 QQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCG 314 + L + S V S++ + Y +++ + D+R + + ++ Sbjct: 263 MPEPLVKLLSARGPVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQ-LHSVESLPTPGTN 321 Query: 315 LRWAPDGRHLASGGNDNLVNVW 336 + + G S G V +W Sbjct: 322 VSISDTGLLALSRG--PHVTLW 341 Score = 32.1 bits (71), Expect = 0.56, Method: Composition-based stats. Identities = 17/85 (20%), Positives = 31/85 (36%), Gaps = 4/85 (4%) Query: 169 PSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEY 228 PS+P+ ++ R +D S + D S+ +W + QL +E Sbjct: 261 PSMPEPLVKLLSARGPVNSIAIDRSGYYMATTGADRSMKIWDIR--NFKQLHSVESLPTP 318 Query: 229 ISSVAWIKEGNYLAVGTSSAEVQLW 253 ++V+ G + V LW Sbjct: 319 GTNVSISDTGLLAL--SRGPHVTLW 341 >6CVZ-A nrPDB Length = 351 Score = 57.5 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 49/323 (15%), Positives = 106/323 (32%), Gaps = 67/323 (20%) Query: 160 SSRKTCRYIPSLPDRILDAPEIRNDYYLNL-------VDWSS---GNVLAVALDNSVYLW 209 ++P ++L +++ Y+ + + +SS G +L+ +LDN++ L Sbjct: 43 QPSPQASFLPGFGVKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLT 102 Query: 210 SASSGDILQLLQMEQPGEYISSVAW-IKEGNYLAVGTSSAEVQLWDVQ-QQKRLRNMTSH 267 S + ++Q G + S W + E NY+ G ++ + ++DV+ ++ + + Sbjct: 103 SLETNTVVQTY---NAGRPVWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQ 159 Query: 268 SARVGSLSWN------------SYILSSGSRSGHIH-------HH------------DVR 296 AR +S + +L+ H D + Sbjct: 160 KARCPLVSLSYMPRAASAAFPYGGVLAGTLEDASFWEQKMDFSHWPHVLPLEPGGCIDFQ 219 Query: 297 VAEHHVATLSGHSQEVCGLRWAPDGRH--LASGGNDNLVNVWPSAPGEGGWVPLQTFTQH 354 L + + PD H + S + + + P+ TF Sbjct: 220 TENSSRHCL---------VTYRPDKNHTTIRSVLMEMSYRLDDTGNPICSCQPVHTFFG- 269 Query: 355 QGAV------KAVAWCP-WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSIL- 406 G A+ P N+L G + +W+ SG+ L + V I Sbjct: 270 -GPTCKLLTKNAIFQSPENDGNILVCTGDEAANSALLWDAASGSLLQDLQTDQPVLDICP 328 Query: 407 WSPHYKELISGHGFAQNQLVIWK 429 + + ++ + W+ Sbjct: 329 FEVNRNSYLATLTEKMVHIYKWE 351 Score = 52.5 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 17/100 (17%), Positives = 41/100 (41%), Gaps = 4/100 (4%) Query: 354 HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKE 413 H ++ +A+ + +L + + D I++ ++ + + +A V S W Sbjct: 73 HGKQIRGLAFSSYLRGLLLSA--SLDNTIKLTSLETNTVVQTYNAGRPVWSCCWCLDEAN 130 Query: 414 LISGHGFAQNQLVIWKYPTMAK-VAELKGHTSRVLSLTMS 452 I G A ++++ + V EL +R +++S Sbjct: 131 YIYA-GLANGSILVYDVRNTSSHVQELVAQKARCPLVSLS 169 Score = 31.3 bits (69), Expect = 0.99, Method: Composition-based stats. Identities = 12/71 (16%), Positives = 25/71 (35%), Gaps = 4/71 (5%) Query: 400 SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TV 458 + ++ S + GF + + M + H ++ L S + Sbjct: 34 DALSCLVISQPSPQASFLPGFG---VKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLL 90 Query: 459 ASAAADETLRL 469 SA+ D T++L Sbjct: 91 LSASLDNTIKL 101 >5LTD-A nrPDB Length = 525 Score = 57.1 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 24/164 (14%), Positives = 62/164 (37%), Gaps = 25/164 (15%) Query: 205 SVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGT------------------- 245 ++Y++ ++ +L ++ + +++ E NYLA + Sbjct: 138 TIYIYDINNMRLLHTIETPSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQ 197 Query: 246 --SSAEVQLWDVQQQKRLRNMTSHSARVGS--LSWNSYILSSGSRSGHI-HHHDVRVAEH 300 + +V ++D + + + +H + + LS + +L++ S G I V Sbjct: 198 TVRNGDVIIFDAKTLQPTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIK 257 Query: 301 HVATLSG-HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEG 343 G + ++ L ++PD R + + V+++ E Sbjct: 258 LYQFRRGTYPTKIYSLAFSPDNRFVIASSATETVHIFRLGEEEA 301 Score = 50.9 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 35/283 (12%), Positives = 95/283 (33%), Gaps = 43/283 (15%) Query: 234 WIKEGNYLAVGTSSAEVQLWDVQQ-QKRLRNMTSHSARVGSLSWNSYILSSGSRS----- 287 + ++ + ++VG S+ ++++ + + V L ++S +L+ Sbjct: 39 FNQDFSCVSVGYSNG-YKIYNCEPFGQCYSKSDGSIGIVEML-FSSSLLAIVGMGEQHSL 96 Query: 288 --GHIHHHDV-RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG 344 + + R T G + ++ + + + + ++ Sbjct: 97 SPRRLKIINTKRQTTICELTFPG---AILAVKLNRERLVVL---LEETIYIYDI----NN 146 Query: 345 WVPLQTFTQHQGAVKAVAWCPWQSNVLATGGG---------------TSDRHIR-----I 384 L T +A P N ++ + +R I Sbjct: 147 MRLLHTIETPSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQTVRNGDVII 206 Query: 385 WNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK--GH 442 ++ + S ++AH + + L++ + ++ T K+ + + + Sbjct: 207 FDAKTLQPTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTY 266 Query: 443 TSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREK 485 +++ SL SPD V +++A ET+ ++R E + A + Sbjct: 267 PTKIYSLAFSPDNRFVIASSATETVHIFRLGEEEAANTIKSAN 309 >3DW8-B nrPDB Length = 447 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 45/362 (12%), Positives = 101/362 (27%), Gaps = 106/362 (29%) Query: 229 ISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLR-----------NMTSH---------- 267 IS+V + G LA G V ++ +Q+ +++ SH Sbjct: 31 ISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSL 90 Query: 268 --SARVGSLSW----NSYILSSGSRSGHIHHHDVRVAEHH------------------VA 303 ++ + W N+ + I + + V Sbjct: 91 EIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVT 150 Query: 304 TLS---------------------GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE 342 TL H+ + + D S +D +N+W + Sbjct: 151 TLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSA-DDLRINLWHLEITD 209 Query: 343 GGWVPL----QTFTQHQGAVKAVAWCPWQSN--VLATGGGT-----------SDRHIRIW 385 + + + + A + P N V ++ GT DRH +++ Sbjct: 210 RSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLF 269 Query: 386 NVCSGACLSAVDAH--SQVCSILWSPHYKELISGHGFAQNQLVIWKYP-TMAKVAELKGH 442 + + S + + +S + +++ + + +W V + H Sbjct: 270 EEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLS---VKVWDLNMENRPVETYQVH 326 Query: 443 T---SRVLSL------------TMSPDGATVASAAADETLRLWRC-FELDPARRREREKA 486 S++ SL + + V + + + R++ + D RE Sbjct: 327 EYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENN 386 Query: 487 SA 488 Sbjct: 387 KP 388 Score = 51.7 bits (122), Expect = 6e-07, Method: Composition-based stats. Identities = 53/380 (13%), Positives = 105/380 (27%), Gaps = 83/380 (21%) Query: 78 RYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSGKP 137 R++P ++AAQ ++ T + K W ++ E + G+ Sbjct: 100 RWLPQKNAAQFLLS----------------TNDKTIKLWKISERDKRPEGYNLKEEDGRY 143 Query: 138 QNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNV 197 ++ R+ V +S + N +N S Sbjct: 144 RDPTTVTTLRVPVFRPMDLMVEASPRRIFANA--------HTYHINSISIN----SDYET 191 Query: 198 LAVALDNSVYLWSASSGD------ILQLLQMEQPGEYISSVAWIKEG-NYLAVGTSSAEV 250 A D + LW D ++ ME+ E I++ + N +S + Sbjct: 192 YLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTI 251 Query: 251 QLWDVQQQ---KRLRNMTSHSARVGSLSWNSYILSSGSRSG--------------HIHHH 293 +L D++ R + + S+ S I+SS S + Sbjct: 252 RLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKVW 311 Query: 294 DVRVAEHHVATLSGHSQ---EVCGL------------RWAPDGRHLASGGNDNLVNVWPS 338 D+ + V T H ++C L W + +G +N ++ Sbjct: 312 DLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDR 371 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 + V V A+G D + ++D Sbjct: 372 NTKRDITLEASRENNKPRTVL------KPRKVCASGKRKKDEI----------SVDSLDF 415 Query: 399 HSQVCSILWSPHYKELISGH 418 + ++ W P + Sbjct: 416 NKKILHTAWHPKENIIAVAT 435 Score = 49.4 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 41/356 (11%), Positives = 101/356 (28%), Gaps = 56/356 (15%) Query: 97 KENQPENSQTPTKKEHQKAWALNLNGFDVEEAKIL--------RLSGKPQNAPEGYQNRL 148 + Q SQ + A A ++ + + L R+ Q Q+ Sbjct: 8 NDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHS 67 Query: 149 KVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDW----SSGNVLAVALDN 204 + Y+ +T S Y+ SL +N + W ++ L D Sbjct: 68 RGEYNVYSTFQSHEPEFDYLKSLEIEEK----------INKIRWLPQKNAAQFLLSTNDK 117 Query: 205 SVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNM 264 ++ LW S + + E + + D+ + R + Sbjct: 118 TIKLWKIS----ERDKRPEGYNLKEEDGRYRDPTT--VTTLRVPVFRPMDLMVEASPRRI 171 Query: 265 --TSHSARVGSLSWNS-YILSSGSRSGHIHHHDVRVAEHHVAT-------LSGHSQEVCG 314 +H+ + S+S NS Y + I+ + + + + ++ + Sbjct: 172 FANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITA 231 Query: 315 LRWAPDG-RHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGA------------VKAV 361 + P+ + + + + F + + + V Sbjct: 232 AEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDV 291 Query: 362 AWCPWQSNVLATGGGTSDRHIRIWNVC-SGACLSAVDAHSQVCSILWSPHYKELIS 416 + ++ + +++W++ + H + S L S + + I Sbjct: 292 KFSHSGRYMMTRDYLS----VKVWDLNMENRPVETYQVHEYLRSKLCSLYENDCIF 343 >5AJA-A nrPDB Length = 361 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 30/230 (13%), Positives = 74/230 (32%), Gaps = 32/230 (13%) Query: 230 SSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSL--SWNSYILSSGSRS 287 + A+ +L +GT + +++L++V + + H++ + L S + +L + + Sbjct: 41 TCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATW 100 Query: 288 GH--IHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGW 345 ++ + + + ++ + G ++ +++ G Sbjct: 101 SQPLSALWGMKSVFDMKHSFTEDHY----VEFSKHSQDRVIGTKGDIAHIYDIQTGNKLL 156 Query: 346 VPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSI 405 + + P VL G +W+V S + D + S Sbjct: 157 TLFNPDLANNYKRNCATFNPTDDLVLNDGV--------LWDVRSAQAIHKFDKFNMNISG 208 Query: 406 LWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKG---------HTSRV 446 ++ P+ E+I IW T + + HT V Sbjct: 209 VFHPNGLEVII-------NTEIWDLRTFHLLHTVPALDQCRVVFNHTGTV 251 Score = 37.8 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 14/67 (20%), Positives = 27/67 (40%), Gaps = 2/67 (2%) Query: 397 DAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA 456 + S +S + L+ G QL ++ + + A H S + L S DG+ Sbjct: 35 EDESGFTCCAFSARERFLMLGTCT--GQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGS 92 Query: 457 TVASAAA 463 + ++A Sbjct: 93 LLLTSAT 99 >6IYY-A nrPDB Length = 317 Score = 55.9 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 43/282 (15%), Positives = 95/282 (33%), Gaps = 18/282 (6%) Query: 110 KEHQKAWALN-LNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLY--SQKATPGSSRKTCR 166 + +A NGF V L+ + Q EG +++L+ + A G +K Sbjct: 16 NQDHGCFACGMENGFRVYNTDPLK-EKEKQEFLEGGVGHVEMLFRCNYLALVGGGKKKVM 74 Query: 167 YIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWS--ASSGDILQLLQMEQ 224 L + + EI + V ++ V LD+ + +++ + + Sbjct: 75 IWDDLKKKTV--IEIEFSTEVKAVKLRRDRIVVV-LDSMIKVFTFTHNPHQLHVFETCYN 131 Query: 225 PGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ-QQKRLRNMTSHSARVGSLSWN--SYIL 281 P GT + VQL D+ +K ++ +H + ++ N + Sbjct: 132 PKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEGVLSCIALNLQGTRI 191 Query: 282 SSGSRSGH-IHHHDVRVAEHHVATLSG-HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSA 339 ++ S G I D G + + + + D + + V+++ + Sbjct: 192 ATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFNQDASLICVSSDHGTVHIFAAE 251 Query: 340 PGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRH 381 + W +F++ Q + C + + A +D Sbjct: 252 DPKSKW----SFSKFQVPSGSPCICAFGTEPNAVIAICADGS 289 Score = 52.1 bits (123), Expect = 6e-07, Method: Composition-based stats. Identities = 30/264 (11%), Positives = 76/264 (28%), Gaps = 57/264 (21%) Query: 225 PGEYISSVAWIKEGNYLAVGTSSAEVQLWD---VQQQKRLRNMTSHSARVGSLSWNSYIL 281 G + + ++ A G + ++++ ++++++ + V L +Y+ Sbjct: 6 HGNGLLYAGFNQDHGCFACGMENG-FRVYNTDPLKEKEKQEFLEGGVGHVEMLFRCNYLA 64 Query: 282 SSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPG 341 G + D + S EV ++ D + D+++ V+ Sbjct: 65 LVGGGKKKVMIWD--DLKKKTVIEIEFSTEVKAVKLRRDRIVVV---LDSMIKVFTF--- 116 Query: 342 EGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ 401 T HQ V + P Sbjct: 117 --------THNPHQLHVFETCYNPKG---------------------------------- 134 Query: 402 VCSILWSPHYKELISGHGFAQNQLVIWKY-PTMAKVAELKGHTSRVLSLTMSPDGATVAS 460 +L L++ G + + T ++ H + + ++ G +A+ Sbjct: 135 -LCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEGVLSCIALNLQGTRIAT 193 Query: 461 AAADET-LRLWRCFELDPARRRER 483 A+ T +R++ + R Sbjct: 194 ASEKGTLIRIFDTSSGHLIQELRR 217 Score = 46.7 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 21/190 (11%), Positives = 63/190 (33%), Gaps = 20/190 (10%) Query: 204 NSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKR-LR 262 V +W + ++ + +V ++ + V + ++++ L Sbjct: 71 KKVMIWDDLKKKTVIEIEF---STEVKAVKLRRD-RIVVV--LDSMIKVFTFTHNPHQLH 124 Query: 263 NMTSHSAR----VGSLSWNSYILS-SGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRW 317 + V + N+ +L+ G+ +GH+ D+ E + H + + Sbjct: 125 VFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEGVLSCIAL 184 Query: 318 APDGRHLASGGNDNL-VNVWPSAPGEGGWVPLQTFTQHQGA-VKAVAWCPWQSNVLATGG 375 G +A+ + ++ ++ G + Q A + + + S + + Sbjct: 185 NLQGTRIATASEKGTLIRIFDTSSGHLIQELRR---GSQAANIYCINFNQDASLICVS-- 239 Query: 376 GTSDRHIRIW 385 + + I+ Sbjct: 240 -SDHGTVHIF 248 >5K1H-B nrPDB Length = 576 Score = 52.1 bits (123), Expect = 5e-07, Method: Composition-based stats. Identities = 40/216 (18%), Positives = 80/216 (37%), Gaps = 23/216 (10%) Query: 253 WDVQQQKRLRNMTS---HSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHS 309 WD+ +++ +++ + S I SG + + V+ Sbjct: 110 WDIPEKQPFKDLGNLRYWLEEAECRDQYSVIFESG--DRTSIFWN--DVKDPVSIEERAR 165 Query: 310 QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 369 +RW+P G +LA+ + + +W G + +Q F+ HQG V+ + + P + Sbjct: 166 WTETYVRWSPKGTYLATF-HQRGIALW----GGEKFKQIQRFS-HQG-VQLIDFSPCERY 218 Query: 370 VLATGGGTS--D--RHIRIWNVCSGACLSAVDAHSQVC--SILWSPHYKELISGHGFAQN 423 ++ D + I IW++ +G S WS K + Sbjct: 219 LVTFSPLMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFF---ARMTLD 275 Query: 424 QLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVA 459 L I++ P+M + + S + + SP G +A Sbjct: 276 TLSIYETPSMGLLDKKSLKISGIKDFSWSPGGNIIA 311 Score = 46.7 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 41/288 (14%), Positives = 95/288 (32%), Gaps = 50/288 (17%) Query: 201 ALDNSVYLWSASSGDILQLLQMEQPGEYISS-VAWIKEGNYLAVGTSSAEVQLWDVQQQK 259 + D + W+ D+ + +E+ + + V W +G YLA + LW ++ K Sbjct: 143 SGDRTSIFWN----DVKDPVSIEERARWTETYVRWSPKGTYLAT-FHQRGIALWGGEKFK 197 Query: 260 RLRNMTSHSARVGSLSWNS--YILSSGS--RSGH-----IHHHDVRVAEHHVATLSGHSQ 310 +++ + H V + ++ L + S I D+ L+GH + Sbjct: 198 QIQRFS-HQG-VQLIDFSPCERYLVTFSPLMDTQDDPQAIIIWDI---------LTGHKK 246 Query: 311 EVCGL---------RWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 361 +W+ DG+ A D ++++ + + +K Sbjct: 247 RGFHCESSAHWPIFKWSHDGKFFARMTLD-TLSIYETPSMGLLDKKSLKISG----IKDF 301 Query: 362 AWCPWQSNVLATGGGTSD--RHIRIWNVCSGACLSAVDAHSQV-CSILWSPHYKELIS-- 416 +W P + + D + + + S + + + V C + W + L Sbjct: 302 SWSPGGNIIAFWVPEDKDIPARVTLMQLPSRQEIRVRNLFNVVDCKLHWQKNGDYLCVKV 361 Query: 417 -----GHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVA 459 G I++ ++ +++ P+G+ A Sbjct: 362 DRTPKGTQGVVTNFEIFRMREKQVPVDVVEMKETIIAFAWEPNGSKFA 409 Score = 36.3 bits (82), Expect = 0.031, Method: Composition-based stats. Identities = 18/112 (16%), Positives = 34/112 (30%), Gaps = 12/112 (10%) Query: 368 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVI 427 + + + DR WN A + WSP L + H Q + + Sbjct: 134 RDQYSVIFESGDRTSIFWNDVKDPVSIEERARWTETYVRWSPKGTYLATFH---QRGIAL 190 Query: 428 WKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAA------AD-ETLRLWRC 472 W ++ H V + SP + + + D + + +W Sbjct: 191 WGGEKFKQIQRFS-HQG-VQLIDFSPCERYLVTFSPLMDTQDDPQAIIIWDI 240 >5WLC-LH nrPDB Length = 896 Score = 50.9 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 21/82 (25%), Positives = 39/82 (47%), Gaps = 4/82 (4%) Query: 268 SARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLA 325 + V S++ + L+ G SG I V +A+ + L H V L ++ DG +L Sbjct: 256 TRYVSSMAIDNMGQQLAVGFASGVISI--VSLADLQIRLLKWHIDSVLSLSFSHDGSYLL 313 Query: 326 SGGNDNLVNVWPSAPGEGGWVP 347 SGG + ++++W ++P Sbjct: 314 SGGWEKVMSLWQLETNSQQFLP 335 Score = 45.2 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 20/71 (28%), Positives = 33/71 (46%), Gaps = 3/71 (4%) Query: 402 VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASA 461 V S+ ++L GFA + I + + LK H VLSL+ S DG+ + S Sbjct: 259 VSSMAIDNMGQQL--AVGFASGVISIVSLADLQ-IRLLKWHIDSVLSLSFSHDGSYLLSG 315 Query: 462 AADETLRLWRC 472 ++ + LW+ Sbjct: 316 GWEKVMSLWQL 326 Score = 40.5 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 37/289 (12%), Positives = 91/289 (31%), Gaps = 65/289 (22%) Query: 229 ISSVAWIKEGNYLAV-----------GTSSAE--VQLW---DVQQQKRLRN--MTSHSAR 270 I+ + + K+G ++ + ++ W D + L+ + H Sbjct: 495 ITDLKFTKDGQWMITYEIEYPPNDLLSSKDLTHILKFWTKNDNETNWNLKTKVINPHGIS 554 Query: 271 V---------GSLSWNSYILSSGSRSGHIHHH--DVRVAEHHVATLSG----HSQEVCGL 315 V S++ NS + +G + D + + +S H L Sbjct: 555 VPITKILPSPRSVN-NSQGCLTADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSL 613 Query: 316 RWAPDGRHLASGGNDNL-VNVWPSAPGEGGWVPLQTFTQHQ--GAVKAVAWCPWQSNVLA 372 W+ DG + G +D L + + + +T ++ ++ V + ++A Sbjct: 614 AWSQDGSLIFHGFDDKLQILDFDTFKKFESLENTKTVSEFTLDSEIQTVKLINDTNLIVA 673 Query: 373 TGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISG--------------- 417 T + N+ G +++ D + V + + H LI+ Sbjct: 674 TRT-----TLNAINLLRGQVINSFDLYPFVNGVYKNGHMDRLITCDERTGNIALVINQQL 728 Query: 418 -------HGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVA 459 +++++I+ K+ H + + + D + Sbjct: 729 TDLDGVPTINYKSRIIIFDSDLSTKLGNFTHHE-YISWIGWNYDTDFIF 776 Score = 39.8 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 18/89 (20%), Positives = 35/89 (39%), Gaps = 3/89 (3%) Query: 171 LPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYIS 230 L + +D + G LAV + V S S LQ+ ++ + + Sbjct: 245 LSSQTQSLSYNTRYVSSMAID-NMGQQLAVGFASGVI--SIVSLADLQIRLLKWHIDSVL 301 Query: 231 SVAWIKEGNYLAVGTSSAEVQLWDVQQQK 259 S+++ +G+YL G + LW ++ Sbjct: 302 SLSFSHDGSYLLSGGWEKVMSLWQLETNS 330 Score = 39.4 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 37/235 (15%), Positives = 77/235 (32%), Gaps = 32/235 (13%) Query: 190 VDWSSGNVLAVALDNSVYLWSASSGD---ILQLLQMEQPGEYISSV--AWIKEGNYLAVG 244 V+ S G + A + + WS S + L+ + + + +SV AW ++G+ + G Sbjct: 567 VNNSQGCLTA-DNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSLAWSQDGSLIFHG 625 Query: 245 TSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVAT 304 +Q+ D K+ ++ + + V + +S I + + R + + Sbjct: 626 FDDK-LQILDFDTFKKFESLEN-TKTVSEFTLDSEIQTVKLINDTNLIVATRTTLNAINL 683 Query: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPG---EGGWVPLQTFTQHQGAVKAV 361 L G D ++P G G L T + G + A+ Sbjct: 684 LRGQ----------------VINSFD----LYPFVNGVYKNGHMDRLITCDERTGNI-AL 722 Query: 362 AWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELIS 416 +++ I I++ L H + I W+ + Sbjct: 723 VINQQLTDLDGVPTINYKSRIIIFDSDLSTKLGNFTHHEYISWIGWNYDTDFIFL 777 Score = 38.2 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 28/194 (14%), Positives = 55/194 (28%), Gaps = 54/194 (27%) Query: 312 VCGLRWAPDGRHLAS-----------GGND--NLVNVWPSAPGEGGWVP-LQTFTQHQGA 357 + L++ DG+ + + D +++ W E W + H + Sbjct: 495 ITDLKFTKDGQWMITYEIEYPPNDLLSSKDLTHILKFWTKNDNETNWNLKTKVINPHGIS 554 Query: 358 VKAVAWCPWQSNVL-ATGGGTSDRH--IRIWNVCSGACLSAVDAHSQVCSILWSPHYKEL 414 V P +V + G T+D + ++ W + D+H + Sbjct: 555 VPITKILPSPRSVNNSQGCLTADNNGGLKFW---------SFDSHESNWCL--------- 596 Query: 415 ISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474 H S +SL S DG+ + D+ L++ Sbjct: 597 ------------------KKISLPNFNHFSNSVSLAWSQDGSLIFHGFDDK-LQILDFDT 637 Query: 475 LDPARRREREKASA 488 E K + Sbjct: 638 FKKFESLENTKTVS 651 >2VDU-B nrPDB Length = 450 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 26/184 (14%), Positives = 58/184 (31%), Gaps = 27/184 (14%) Query: 235 IKEGNYLAVGTSSAEVQLWDV-QQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHH- 292 E +A S + ++DV + K + + S +S + Sbjct: 112 SDESRLIACADSDKSLLVFDVDKTSKNVLKLRKR----FCFSKRPNAISIAEDDTTVIIA 167 Query: 293 --------HDVRVAEHHVATLS---GHSQEVCGLRW---APDGRHLASGGNDNLVNVWPS 338 D+ T GH + + + + + + D + + Sbjct: 168 DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI--- 224 Query: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 + ++ + H+ V ++ + +L + GG D I W+ +G LS D Sbjct: 225 SHYPQCFIVDKWLFGHKHFVSSICC--GKDYLLLSAGG--DDKIFAWDWKTGKNLSTFDY 280 Query: 399 HSQV 402 +S + Sbjct: 281 NSLI 284 Score = 49.4 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 41/251 (16%), Positives = 87/251 (34%), Gaps = 21/251 (8%) Query: 105 QTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKT 164 Q+P E W+ + FD + + + Q +N K L S K Sbjct: 33 QSPNHWEFAGKWS---DDFDKIQESRNTTAKEQQGQSSENENENKKLKSNKGDSIK---- 85 Query: 165 CRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVAL-DNSVYLWSAS--SGDILQLLQ 221 R +P L AP I + + ++A A D S+ ++ S ++L+L + Sbjct: 86 -RTAAKVPSPGLGAPPIYSYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRK 144 Query: 222 MEQPGEYISSVAWIKEGNYLAVGTSSA---EVQLWDVQQQKRLRN-MTSHSARVGSL--- 274 + ++++ ++ + + + + + ++K + + H + + + Sbjct: 145 RFCFSKRPNAISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLI 204 Query: 275 -SWNSYI-LSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNL 332 + + + + R HI L GH V + D L S G D+ Sbjct: 205 KDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDK 263 Query: 333 VNVWPSAPGEG 343 + W G+ Sbjct: 264 IFAWDWKTGKN 274 Score = 41.7 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 31/169 (18%), Positives = 56/169 (33%), Gaps = 10/169 (5%) Query: 310 QEVCGLRWAPD-GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS 368 + LR D R +A +D + V+ + L+ A++ + Sbjct: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDT 162 Query: 369 NVLATGGGTSDRHIRIWNVCSGACLSA-VDAH----SQVCSILWSPHYKELISGHGFAQN 423 V+ I I ++ + H + V I S ++ +I+ Sbjct: 163 TVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITS--DRDE 220 Query: 424 QLVIWKYPTMAKVAE-LKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 + I YP V + L GH V S+ D + SA D+ + W Sbjct: 221 HIKISHYPQCFIVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWD 268 >5WLC-LS nrPDB Length = 594 Score = 48.2 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 30/150 (20%), Positives = 55/150 (36%), Gaps = 15/150 (10%) Query: 204 NSVYLWSASSG---DILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWD------ 254 + + W G +Q+ ++ IK+ +LAVG+ S V L+D Sbjct: 442 HVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMT 501 Query: 255 VQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVAT---LSGHS 309 + + + + +L + + IL SR+ V + V + SG Sbjct: 502 SSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTP 561 Query: 310 -QEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 +V + ++P G LA G V +W Sbjct: 562 LGKVTSVAFSPSGGLLAVGNEQGKVRLWKL 591 Score = 46.3 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 46/375 (12%), Positives = 104/375 (27%), Gaps = 59/375 (15%) Query: 153 SQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSAS 212 + + K I L D P L+ S +L D ++ ++ Sbjct: 221 TLSNSKLLPPKKLD-IVRLKDANASHPSHSAIQSLSFHP-SKPLLLTGGYDKTLRIYHID 278 Query: 213 SGDILQLLQMEQPGEYISSVAW-----IKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSH 267 + + G I + + + + + WD+ + + T+ Sbjct: 279 GKTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAK 338 Query: 268 SARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHH-VATLSGHSQEVCGLRWAPDGRHLAS 326 + L + S H + + H + L G++ + L + G L Sbjct: 339 IEKFSRLYGHESTQRSFENFKVAHLQNSQTNSVHGIVLLQGNNGWINILH-STSGLWLMG 397 Query: 327 GGNDNLV--------------------------NVWPSAPGEGGWV-------------P 347 + ++ VW + G V Sbjct: 398 CKIEGVITDFCIDYQPISRGKFRTILIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITK 457 Query: 348 LQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA-------HS 400 +Q A+ + N G+ + +++ + S + Sbjct: 458 IQVGGGTTTTCPALQISKIKQNRWL-AVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTT 516 Query: 401 QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHT---SRVLSLTMSPDGAT 457 + ++ +SP + L ++ L + P+ + + +V S+ SP G Sbjct: 517 TISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGL 576 Query: 458 VASAAADETLRLWRC 472 +A +RLW+ Sbjct: 577 LAVGNEQGKVRLWKL 591 Score = 38.6 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 24/138 (17%), Positives = 49/138 (35%), Gaps = 8/138 (5%) Query: 122 GFDVEEAKILRLSGKP-QNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPE 180 G + + P + QNR + S+ + S P + + Sbjct: 454 GITKIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQ 513 Query: 181 IRNDYYLNLVDWSSG----NVLAVALDNSVYLWSASSGDILQLLQMEQ-PGEYISSVAWI 235 + ++ + +S + + A+ +++ L S + P ++SVA+ Sbjct: 514 L--TTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFS 571 Query: 236 KEGNYLAVGTSSAEVQLW 253 G LAVG +V+LW Sbjct: 572 PSGGLLAVGNEQGKVRLW 589 >6N8P-A nrPDB Length = 979 Score = 47.1 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 44/248 (17%), Positives = 74/248 (29%), Gaps = 45/248 (18%) Query: 267 HSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLAS 326 H S + IL+ G+RSG I + L + V + P L + Sbjct: 22 HQPSALGYSPSLRILAIGTRSGAIKLY--GAPGVEFMGLHQENNAVTQIHLLPGQCQLVT 79 Query: 327 GGNDNLVNVWPSA----PGEGGWVPLQTFTQHQG----AVKAVAWCPWQS-NVLATGGGT 377 +DN +++W E T G A + P S +L G + Sbjct: 80 LLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTES 139 Query: 378 --------------SDRHIRIWNVCSGACLSAVDAHSQ-------VCSILWSPHYKELIS 416 DR I S A L + ++ V ++ P I Sbjct: 140 GNVFVVQLPAFRALEDRTI-----SSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQIL 194 Query: 417 GHGFAQNQLVIWKYPTMAKVAELKGHTS--RVLSLTMSPDGATVASAAADETLRLWRCFE 474 G+++ +VIW + + DG + S +D + W Sbjct: 195 I-GYSRGLVVIWDLQGSRVLYHFLSSQQLENIW---WQRDGRLLVSCHSDGSYCQWPVS- 249 Query: 475 LDPARRRE 482 A++ E Sbjct: 250 -SEAQQPE 256 Score = 42.8 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 40/250 (16%), Positives = 72/250 (28%), Gaps = 49/250 (19%) Query: 222 MEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVG--SLSWNSY 279 S++ + LA+GT S ++L+ + + V L Sbjct: 17 EHGFPHQPSALGYSPSLRILAIGTRSGAIKLYG-APGVEFMGLHQENNAVTQIHLLPGQC 75 Query: 280 ILSSGSRSGHIHHHDVRV-------AEHHVATLSG----------------HSQEVCGLR 316 L + +H ++V E TL G HS C L Sbjct: 76 QLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSS--CELL 133 Query: 317 W--APDGRHLAS------GGNDNLVNVWPSAPGEGGWVPLQTFTQHQGA---VKAVAWCP 365 + G D + + L +H+ V+A+ P Sbjct: 134 YLGTESGNVFVVQLPAFRALEDRTI------SSDAVLQRLPEEARHRRVFEMVEALQEHP 187 Query: 366 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQL 425 N + G + IW++ L + Q+ +I W + L+S H + Sbjct: 188 RDPNQILIGYSR--GLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCH--SDGSY 243 Query: 426 VIWKYPTMAK 435 W + A+ Sbjct: 244 CQWPVSSEAQ 253 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 17/75 (22%), Positives = 28/75 (37%), Gaps = 2/75 (2%) Query: 277 NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 336 + + G G + D++ + LS E + W DGR L S +D W Sbjct: 189 DPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLE--NIWWQRDGRLLVSCHSDGSYCQW 246 Query: 337 PSAPGEGGWVPLQTF 351 P + PL++ Sbjct: 247 PVSSEAQQPEPLRSL 261 Score = 31.3 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 15/99 (15%), Positives = 35/99 (35%), Gaps = 5/99 (5%) Query: 391 ACLSAVDAH--SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLS 448 V+ Q ++ +SP + I G + ++ P + + L + V Sbjct: 11 QFNKTVEHGFPHQPSALGYSPSLR--ILAIGTRSGAIKLYGAPGVEFMG-LHQENNAVTQ 67 Query: 449 LTMSPDGATVASAAADETLRLWRCFELDPARRREREKAS 487 + + P + + D +L LW A + +++ Sbjct: 68 IHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESF 106 Score = 29.0 bits (63), Expect = 5.5, Method: Composition-based stats. Identities = 26/176 (14%), Positives = 47/176 (26%), Gaps = 32/176 (18%) Query: 108 TKKEHQKAWALNLNG--FDVEEAKILRLSGKPQNAPEGYQNRLKVLYS------------ 153 W+L + G +++E + L G P AP Q + + +S Sbjct: 81 LDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESG 140 Query: 154 ------------QKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVA 201 + SS + LP+ L +L Sbjct: 141 NVFVVQLPAFRALEDRTISSDAVLQR---LPEEARHRRVFEMVEALQEHPRDPNQILIGY 197 Query: 202 LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQ 257 V +W +L + + ++ W ++G L S W V Sbjct: 198 SRGLVVIWDLQGSRVLY---HFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVSS 250 >4FHN-A nrPDB Length = 394 Score = 45.5 bits (106), Expect = 5e-05, Method: Composition-based stats. Identities = 36/206 (17%), Positives = 66/206 (32%), Gaps = 31/206 (15%) Query: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 252 S N+LA+ D + I + + PG ++ + T + L Sbjct: 30 SCSNLLAIGHDTGI--------TIYCASEEQTPGSTGLTLQ-----ELFTIQTGLPTLHL 76 Query: 253 WDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVA----EHHVATLSGH 308 N+ V S S L+ + + + +H + SGH Sbjct: 77 SFSSSCSYSENLHDGDGNVNSSPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGH 136 Query: 309 SQEVCGLR----WAPDGRH----LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 360 V + ++ D R +AS G+D + +W P+ + Sbjct: 137 HNFVNDIDIADVYSADNRLAEQVIASVGDDCTLIIWRLTDE----GPILAGYPLSSPGIS 192 Query: 361 VAWCPWQSNVLATGGGTSDRHIRIWN 386 V + P N L G + +IRI++ Sbjct: 193 VQFRPSNPNQLIV--GERNGNIRIFD 216 Score = 37.5 bits (85), Expect = 0.013, Method: Composition-based stats. Identities = 15/108 (13%), Positives = 37/108 (34%), Gaps = 14/108 (12%) Query: 202 LDNSV--YLWSASSGDILQLLQME-QPGEYISSVA----WIKEGNY----LAVGTSSAEV 250 DN+V + + +L + +++ + + + +A + Sbjct: 110 QDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVYSADNRLAEQVIASVGDDCTL 169 Query: 251 QLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDV 295 +W + + + S+ S+ + N L G R+G+I D Sbjct: 170 IIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGERNGNIRIFDW 217 Score = 34.4 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 18/93 (19%), Positives = 31/93 (33%), Gaps = 14/93 (15%) Query: 399 HSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL-----KGHTSRVLSLT--- 450 H ++ SP Y ++ N + + + + GH + V + Sbjct: 89 HDGDGNVNSSPVYSLFLACVCQ-DNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIAD 147 Query: 451 -MSPDG----ATVASAAADETLRLWRCFELDPA 478 S D +AS D TL +WR + P Sbjct: 148 VYSADNRLAEQVIASVGDDCTLIIWRLTDEGPI 180 >3WJ9-A nrPDB Length = 412 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 18/127 (14%), Positives = 40/127 (31%), Gaps = 15/127 (11%) Query: 309 SQEVCGLRWAPDGRHL--ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW 366 + + W D + G ++ + +P + + P Sbjct: 268 EGPIHDVCWNADSKEFGIVYGYMPAKTAIFDNRANVVSIIP-------PAPRNTLIFSPN 320 Query: 367 QSNVLATGGGTSDRHIRIWNVCSG-ACLSAVDAHSQVCSILWSPHYKELISGHGFA---- 421 +L G G I I++ + ++ V+A + +SP + L++ Sbjct: 321 SRYILLAGFGNLQGSIDIFDAANNMKKITTVEA-ANCTYCEFSPDSQFLLTAVTSPRLRV 379 Query: 422 QNQLVIW 428 N + IW Sbjct: 380 DNSIKIW 386 >5WLC-LL nrPDB Length = 643 Score = 43.2 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 32/243 (13%), Positives = 77/243 (31%), Gaps = 36/243 (14%) Query: 198 LAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAW----IKEGNYLAVGTSSAEVQLW 253 + +D +W+ L +E ++ + W + + +G ++ E+ L+ Sbjct: 38 TSSGVDT---VWN------ENFLYLEDSKLKVTCLKWVNLASSDTVAIILGMNNGEIWLY 88 Query: 254 DVQQQKRLRNMT-SHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEV 312 V + T +S + + L S + D+ + L H + Sbjct: 89 SVLANEVTYKFTTGNSYEIKDIDLMGNQLWCIDSSDAFYQFDLLQFK-----LLQHFRIN 143 Query: 313 CGLRWA-----PDGR---HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 ++ P G L + +++ + + TF H V + Sbjct: 144 NCVQLNKLTIVPAGDSVAQLLVAS--HSISLIDIEEKKV----VMTFPGHVSPVSTLQVI 197 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQ 424 +N G DR + ++++ SG + A S + + S + + Sbjct: 198 ---TNEFFISGAEGDRFLNVYDIHSGMTKCVLVAESDIKELSHSGQADSIAVTTEDGSLE 254 Query: 425 LVI 427 + + Sbjct: 255 IFV 257 Score = 36.7 bits (83), Expect = 0.027, Method: Composition-based stats. Identities = 33/198 (16%), Positives = 64/198 (32%), Gaps = 26/198 (13%) Query: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256 ++ + ++L+S + ++ I + GN L SS +D+ Sbjct: 76 IILGMNNGEIWLYSVLANEVTYKFT-TGNSYEIKDIDL--MGNQLWCIDSSDAFYQFDLL 132 Query: 257 QQKRLRNMTSHSARVGSLSWNSYILSSGSRS--------GHIHHHDVRVAEHHVATLSGH 308 Q K L++ + + N + S I D+ + V T GH Sbjct: 133 QFKLLQHFRIN----NCVQLNKLTIVPAGDSVAQLLVASHSISLIDIE-EKKVVMTFPGH 187 Query: 309 SQEVCGLRWAPDGRHLASGGN-DNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQ 367 V L+ + SG D +NV+ G V + + +K ++ Sbjct: 188 VSPVSTLQVITNE-FFISGAEGDRFLNVYDIHSGMTKCVLVA-----ESDIKELS---HS 238 Query: 368 SNVLATGGGTSDRHIRIW 385 + T D + I+ Sbjct: 239 GQADSIAVTTEDGSLEIF 256 Score = 34.8 bits (78), Expect = 0.089, Method: Composition-based stats. Identities = 20/90 (22%), Positives = 30/90 (33%), Gaps = 13/90 (14%) Query: 383 RIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGH 442 RI N L+ V A V +L + H LI V GH Sbjct: 141 RINNCVQLNKLTIVPAGDSVAQLLVASHSISLI-------------DIEEKKVVMTFPGH 187 Query: 443 TSRVLSLTMSPDGATVASAAADETLRLWRC 472 S V +L + + ++ A D L ++ Sbjct: 188 VSPVSTLQVITNEFFISGAEGDRFLNVYDI 217 >5WLC-LV nrPDB Length = 707 Score = 43.2 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 25/207 (12%), Positives = 66/207 (31%), Gaps = 18/207 (8%) Query: 134 SGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS 193 P+ ++ + + G+S + R L+ P + +N V + Sbjct: 131 LHYTTRIPKFGRSLVYNKVNCDLYVGASGNELYRLNLEKGRFLN-PFKLDTEGVNHVSIN 189 Query: 194 --SGNVLAVALDNSVYLWSASS----GDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247 +G + A N V W S + ++ +++ ++ +G A GTS+ Sbjct: 190 EVNGLLAAGTETNVVEFWDPRSRSRVSKLYLENNIDNRPFQVTTTSFRNDGLTFACGTSN 249 Query: 248 AEVQLWDVQQQKR-LRNMTSHSARVGSLSW-----NSYILSSGSRSGHI-HHHDVRVAEH 300 ++D++ + + + + + W + + I D + Sbjct: 250 GYSYIYDLRTSEPSIIKDQGYGFDIKKIIWLDNVGTENKIVTC--DKRIAKIWDRLDGKA 307 Query: 301 HVATLSGHSQEVCGLRWAPDGRHLASG 327 + + S ++ + P + Sbjct: 308 YASMEP--SVDINDIEHVPGTGMFFTA 332 >4AV8-A nrPDB Length = 339 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 18/149 (12%), Positives = 45/149 (30%), Gaps = 21/149 (14%) Query: 306 SGHSQEVCGLRWAPDGRHLASGGNDNL-VNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 H+ V +R G +A+ D + V+ + G + + ++ + W Sbjct: 176 KAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLD--RTSIIDMRWS 233 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGAC-----------LSAVDAHSQVCS--ILWSPHY 411 P S + + + ++ V + A + + +C+ + S Sbjct: 234 PDGSKL---AVVSDKWTLHVFEVFNDAENKRHVLKDWINIKYFQSEWSICNFKLKVSKGS 290 Query: 412 KELISGHGFAQNQLVIWKYPTMAKVAELK 440 + +++W P K Sbjct: 291 NDCKIAWISDTGLVIVW--PNRRLADTFK 317 Score = 39.8 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 23/141 (16%), Positives = 46/141 (32%), Gaps = 16/141 (11%) Query: 223 EQPGEYISSVAWIKEGNYLAVGTSSAE-VQLWDVQQQKRLRNMTSHSAR--VGSLSW--N 277 + + V ++G+ +A + ++++ +R R + + W + Sbjct: 176 KAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPD 235 Query: 278 SYILSSGSRSGHIHHHDV-RVAEHHVATLSGHSQEVC----GLRWAPDGRHL-AS-GGND 330 L+ S +H +V AE+ L + W+ L S G ND Sbjct: 236 GSKLAVVSDKWTLHVFEVFNDAENKRHVLK---DWINIKYFQSEWSICNFKLKVSKGSND 292 Query: 331 NLVNVWPSAPGEGGWVPLQTF 351 + W S G P + Sbjct: 293 CKIA-WISDTGLVIVWPNRRL 312 Score = 37.1 bits (84), Expect = 0.016, Method: Composition-based stats. Identities = 16/118 (13%), Positives = 42/118 (35%), Gaps = 8/118 (6%) Query: 181 IRNDYYLNLVDWSSGNVLAVALDNS-VYLWSASSGDILQLLQMEQPGEYISSVAWIKEGN 239 N + ++ V + D + + ++ +G +++ + I + W +G+ Sbjct: 178 HANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPDGS 237 Query: 240 YLAVGTSSAEVQLWDV--QQQKRLRNMTSHSA-----RVGSLSWNSYILSSGSRSGHI 290 LAV + + +++V + + + S+ +S GS I Sbjct: 238 KLAVVSDKWTLHVFEVFNDAENKRHVLKDWINIKYFQSEWSICNFKLKVSKGSNDCKI 295 Score = 33.6 bits (75), Expect = 0.21, Method: Composition-based stats. Identities = 15/87 (17%), Positives = 36/87 (41%), Gaps = 2/87 (2%) Query: 396 VDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSR--VLSLTMSP 453 V AH+ ++ ++++ + +++ V E + R ++ + SP Sbjct: 175 VKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSP 234 Query: 454 DGATVASAAADETLRLWRCFELDPARR 480 DG+ +A + TL ++ F +R Sbjct: 235 DGSKLAVVSDKWTLHVFEVFNDAENKR 261 >2I3T-A nrPDB Length = 341 Score = 42.5 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 10/64 (15%), Positives = 26/64 (40%), Gaps = 1/64 (1%) Query: 229 ISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSH-SARVGSLSWNSYILSSGSRS 287 ++S+ + +L S + W++Q +K+++N V ++ + IL + Sbjct: 254 VNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACSDNILCLATSD 313 Query: 288 GHIH 291 Sbjct: 314 DTFK 317 Score = 41.7 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 24/214 (11%), Positives = 75/214 (35%), Gaps = 33/214 (15%) Query: 191 DWSSGNVLAVALDNSVYLWSA-SSGD-ILQLLQMEQPGEYISSVAWIKEGNY--LAVGTS 246 + ++A + D + + + GD ++ + + + + + + N L VG + Sbjct: 109 KYGDDKLIAASWDGLIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMN 168 Query: 247 SAEVQLWDV---QQQKRLRNMTSHSARVGSLSWNSYI---LSSGSRSGHIHH--HDVRVA 298 +++VQ + + + + ++ ++ + S G + D + Sbjct: 169 NSQVQWFRLPLCEDDNGTIEESGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGD 228 Query: 299 EHHVAT---LSGHS---------QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV 346 +++ + H V + ++P + L + G+D +++ W + Sbjct: 229 DYNSSKRFAFRCHRLNLKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKK--- 285 Query: 347 PLQTFTQHQ-GAVKAVAWCPWQSNVLATGGGTSD 379 ++ F + +V +A + + D Sbjct: 286 -IKNFAKFNEDSVVKIACSDN----ILCLATSDD 314 >4YHC-A nrPDB Length = 468 Score = 40.5 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 28/129 (21%), Positives = 47/129 (36%), Gaps = 13/129 (10%) Query: 285 SRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG 344 S +H R+ V H ++ + + + + AS G D + VW Sbjct: 10 STDTTLHEEKFRIEPVPVH----HQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTK 65 Query: 345 WVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCS 404 V + Q +KA+A P + V + D + I NV S + + HS+ S Sbjct: 66 LVLSK--EQMPRTLKAIALDPQGNYVSLF---SKD-TLFILNVESPSLMLQHSYHSKPNS 119 Query: 405 ---ILWSPH 410 + W P Sbjct: 120 KLNVFWMPG 128 Score = 38.2 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 23/127 (18%), Positives = 47/127 (37%), Gaps = 13/127 (10%) Query: 181 IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY 240 + D V + +V LD S+ +W +L EQ + ++A +GNY Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNY 88 Query: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS------------WNSYILSSGSRSG 288 +++ + + + +V+ + + HS L+ W ++ L SG Sbjct: 89 VSLFSKD-TLFILNVESPSLMLQHSYHSKPNSKLNVFWMPGTHKDDEWKNFELVVVESSG 147 Query: 289 HIHHHDV 295 I + Sbjct: 148 EIQVFSL 154 Score = 32.1 bits (71), Expect = 0.64, Method: Composition-based stats. Identities = 9/33 (27%), Positives = 16/33 (48%) Query: 442 HTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474 H +L + +S + T AS D +L +W + Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRSLVVWDLRQ 61 >5BPT-A nrPDB Length = 741 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 18/96 (18%), Positives = 44/96 (45%), Gaps = 5/96 (5%) Query: 185 YYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQM---EQPGEYISSVAWIKEGNYL 241 + + + WS L ++ + + +I ++ + E G+ ++ +AW +G L Sbjct: 14 HEIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTGKEVTCLAWRPDGKIL 73 Query: 242 AVGTSS-AEVQLWDVQQQKRLRNMTSHSARVGSLSW 276 A G + +V L DV++ + L + + + + + W Sbjct: 74 AFGLADTKKVILCDVEKPESLHSFSLET-PISCMQW 108 Score = 33.2 bits (74), Expect = 0.29, Method: Composition-based stats. Identities = 14/72 (19%), Positives = 23/72 (31%), Gaps = 13/72 (18%) Query: 400 SQVCSILWSPHYKELISGHGFAQNQL-------VIWKYPTMAKVAELKGHTSRVLSLTMS 452 ++ + WSP + + + L +W P + V L Sbjct: 14 HEIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTGK------EVTCLAWR 67 Query: 453 PDGATVASAAAD 464 PDG +A AD Sbjct: 68 PDGKILAFGLAD 79 >5BPW-A nrPDB Length = 843 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 14/55 (25%), Positives = 28/55 (50%), Gaps = 2/55 (3%) Query: 223 EQPGEYISSVAWIKEGNYLAVGTSS-AEVQLWDVQQQKRLRNMTSHSARVGSLSW 276 E G+ ++ +AW +G LA + ++ L DV++ + L + + A V + W Sbjct: 62 ENTGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSV-EAPVSCMHW 115 Score = 34.0 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 33/180 (18%), Positives = 61/180 (33%), Gaps = 28/180 (15%) Query: 291 HHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGND-NLVNVWPSAPGEGGWVPLQ 349 E+ +EV L W PDG+ LA D + + E L Sbjct: 54 RVWSFPPNENT-------GKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPES----LH 102 Query: 350 TFTQHQGAVKAVAWCP--WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILW 407 +F+ + V + W +S+VL + D N+ + +S I Sbjct: 103 SFSV-EAPVSCMHWMEVTVESSVLTSFYNAEDES----NLLLPKLPTLPKNYSNTSKIFS 157 Query: 408 SPHYKELISGHGFAQNQLVIWKYPTM---------AKVAELKGHTSRVLSLTMSPDGATV 458 + E+I G + +++ + K+A + G L+L +S D ++ Sbjct: 158 EENSDEIIKLLGDVRLNILVLGGSSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSL 217 Score = 33.2 bits (74), Expect = 0.28, Method: Composition-based stats. Identities = 15/72 (20%), Positives = 26/72 (36%), Gaps = 13/72 (18%) Query: 400 SQVCSILWSPHYKELISGHGFAQNQL-------VIWKYPTMAKVAELKGHTSRVLSLTMS 452 ++ ++WSP + + + L +W +P + V L Sbjct: 21 QEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGK------EVTCLAWR 74 Query: 453 PDGATVASAAAD 464 PDG +A A AD Sbjct: 75 PDGKLLAFALAD 86 >2EEP-A nrPDB Length = 706 Score = 38.6 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 21/135 (15%), Positives = 53/135 (39%), Gaps = 15/135 (11%) Query: 205 SVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSA-----EVQLWDVQQQK 259 +V ++ ++G + L E +++++++W + N L V + +V +D + + Sbjct: 236 TVGIYHLATGKTVYLQTGEPKEKFLTNLSWSPDENILYVAEVNRAQNECKVNAYDAETGR 295 Query: 260 RLRNMTSHS-----ARVGSLSW----NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQ 310 +R + + + L++ N+ + R G H + + ++ Sbjct: 296 FVRTLFVETDKHYVEPLHPLTFLPGSNNQFIWQSRRDGWNHLYLYDTTGRLIRQVTKGEW 355 Query: 311 EVCGLR-WAPDGRHL 324 EV + P G L Sbjct: 356 EVTNFAGFDPKGTRL 370 >5GRS-A nrPDB Length = 396 Score = 38.6 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 26/129 (20%), Positives = 46/129 (35%), Gaps = 13/129 (10%) Query: 285 SRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG 344 S +H R+ V H ++ + + + + AS G D + VW Sbjct: 10 STDTTLHEEKFRIEPVPVH----HQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTK 65 Query: 345 WVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH---SQ 401 V + Q +KA+A P + V + D + I NV S + + H + Sbjct: 66 LVLSK--EQMPRTLKAIALDPQGNYVSLF---SKD-TLFILNVESPSLMLQHSYHCKPNS 119 Query: 402 VCSILWSPH 410 ++ W P Sbjct: 120 KLNVFWMPG 128 Score = 35.5 bits (80), Expect = 0.053, Method: Composition-based stats. Identities = 21/127 (16%), Positives = 45/127 (35%), Gaps = 13/127 (10%) Query: 181 IRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY 240 + D V + +V LD + +W +L EQ + ++A +GNY Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNY 88 Query: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS------------WNSYILSSGSRSG 288 +++ + + + +V+ + + H L+ W ++ L SG Sbjct: 89 VSLFSKD-TLFILNVESPSLMLQHSYHCKPNSKLNVFWMPGTHKDDEWKNFELVVVESSG 147 Query: 289 HIHHHDV 295 I + Sbjct: 148 EIQVFSL 154 Score = 30.1 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 9/33 (27%), Positives = 15/33 (45%) Query: 442 HTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474 H +L + +S + T AS D L +W + Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRCLVVWDLRQ 61 >4R40-A nrPDB Length = 411 Score = 37.8 bits (86), Expect = 0.010, Method: Composition-based stats. Identities = 28/164 (17%), Positives = 60/164 (36%), Gaps = 18/164 (10%) Query: 310 QEVCGLRWAPDGRHLA-----SGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 + + W+PDG +A SG + ++ G + +F +H GA A+ Sbjct: 181 EPLMSPAWSPDGSKIAYVTFESGKSALVIQ----TLANGAIRQVASFPRHNGAP---AFS 233 Query: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQ 424 P + + + ++ + ++ SG D S W P + L + Sbjct: 234 PDGTKLAFALSKSGSLNLYVMDLASGQISQVTDGRSNNTEPSWFPDSQNLAYTSDQG-GR 292 Query: 425 LVIWKYPTMAKV---AELKGHTSRVLSLTMSPDGATVASAAADE 465 ++K V +G ++ + +SPDG + +++ Sbjct: 293 PQVYKVNINGGVPQRITWEGSQNQ--NADVSPDGKFLVLVSSNG 334 >1C5K-A nrPDB Length = 439 Score = 37.5 bits (85), Expect = 0.014, Method: Composition-based stats. Identities = 32/163 (19%), Positives = 57/163 (34%), Gaps = 16/163 (9%) Query: 310 QEVCGLRWAPDGRHLA----SGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 365 Q + W+PDG LA G LV G + +F +H GA A+ P Sbjct: 201 QPLMSPAWSPDGSKLAYVTFESGRSALV---IQTLANGAVRQVASFPRHNGAP---AFSP 254 Query: 366 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQL 425 S + T ++ + ++ SG D S W P + L A + Sbjct: 255 DGSKLAFALSKTGSLNLYVMDLASGQIRQVTDGRSNNTEPTWFPDSQNLAFTSDQA-GRP 313 Query: 426 VIWKYP---TMAKVAELKGHTSRVLSLTMSPDGATVASAAADE 465 ++K + +G ++ +S DG + +++ Sbjct: 314 QVYKVNINGGAPQRITWEGSQNQ--DADVSSDGKFMVMVSSNG 354 >3AZQ-A nrPDB Length = 662 Score = 37.1 bits (84), Expect = 0.019, Method: Composition-based stats. Identities = 32/152 (21%), Positives = 47/152 (30%), Gaps = 28/152 (18%) Query: 307 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSA-------PGEGGWVPLQTFT-QHQGAV 358 H V G R +PDGR D+ W +G + +T + A+ Sbjct: 186 AHR-FVTGPRLSPDGRQAVWLAWDHPRMPWEGTELKTARVTEDGRFADTRTLLGGPEEAI 244 Query: 359 KAVAWCPWQSNVLATGGGTSDRHIRIWNV-----CSGACLSAVDAHSQVCSILWSPHYKE 413 W P S ++AT DR WN+ +GA + LW+P + Sbjct: 245 AQAEWAPDGSLIVAT-----DRTGW-WNLHRVDPATGAATQLCRREEEFAGPLWTPGMRW 298 Query: 414 L--------ISGHGFAQNQLVIWKYPTMAKVA 437 HG L I + V Sbjct: 299 FAPLANGLIAVVHGKGAAVLGILDPESGELVD 330 >4MHC-A nrPDB Length = 826 Score = 35.9 bits (81), Expect = 0.036, Method: Composition-based stats. Identities = 15/113 (13%), Positives = 35/113 (30%), Gaps = 18/113 (15%) Query: 377 TSDRHIRIWNVCSGACLSAVD--AHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA 434 TSD + +WN+ + + +D H+ + L P +S ++ + Sbjct: 108 TSDNKLILWNINNSSEYHCIDEIEHTILKVKLVKPSPNTFVSSVENLLIVATLFDIYILT 167 Query: 435 KVAELKGHTSRVLS---------------LTMSPDGATVASAAADETLRLWRC 472 + H + + ++ G + A D + +W Sbjct: 168 ISFNDRTHELNIFNTGLKVNVTGFNVSNIISYERTGQIFFTGATDG-VNVWEL 219 >5CWW-B nrPDB Length = 595 Score = 33.2 bits (74), Expect = 0.24, Method: Composition-based stats. Identities = 16/89 (17%), Positives = 28/89 (31%), Gaps = 10/89 (11%) Query: 391 ACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLT 450 L+ + +H+ IL + + F W V S V+S Sbjct: 127 DFLAVLTSHTVHICILPDSSHLHIQDTTPFKP---KFWTLGPTTHVTS----RSAVVSAV 179 Query: 451 MSP---DGATVASAAADETLRLWRCFELD 476 P +G + + D +R+W D Sbjct: 180 WHPLGVNGHALVTVTEDAIVRVWELSTAD 208 Score = 32.1 bits (71), Expect = 0.62, Method: Composition-based stats. Identities = 16/85 (18%), Positives = 30/85 (35%), Gaps = 8/85 (9%) Query: 261 LRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP- 319 L +TSH+ + L +S++ + + H + V W P Sbjct: 129 LAVLTSHTVHICILPDSSHLHIQDTTPFKPKFWTLGPTTHVTS-----RSAVVSAVWHPL 183 Query: 320 --DGRHLASGGNDNLVNVWPSAPGE 342 +G L + D +V VW + + Sbjct: 184 GVNGHALVTVTEDAIVRVWELSTAD 208 Score = 31.3 bits (69), Expect = 0.90, Method: Composition-based stats. Identities = 23/102 (22%), Positives = 40/102 (39%), Gaps = 14/102 (13%) Query: 290 IHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPL- 348 I + + +A L+ H+ +C L PD HL ++ + P + + L Sbjct: 117 IRQLVMSPNQDFLAVLTSHTVHICIL---PDSSHL---------HIQDTTPFKPKFWTLG 164 Query: 349 -QTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS 389 T + AV + W P N A T D +R+W + + Sbjct: 165 PTTHVTSRSAVVSAVWHPLGVNGHALVTVTEDAIVRVWELST 206 >4IMM-A nrPDB Length = 399 Score = 33.2 bits (74), Expect = 0.29, Method: Composition-based stats. Identities = 17/105 (16%), Positives = 41/105 (39%), Gaps = 11/105 (10%) Query: 195 GNVLAVALDNSVYLWSASSGDIL---QLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQ 251 V+ + D V ++ +G+ L L+ ++ G Y+AVG + V Sbjct: 297 DAVIGSSTDGDVVAFNRMTGEKLWENHDLKYRGLTNPVTI------GTYIAVGDADGVVH 350 Query: 252 LWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVR 296 + + Q ++ + + + +L+ + L + S G + + Sbjct: 351 I--LNHQGQIISRANTKGALTNLTVINNRLYAQSADGVVTVWQFK 393 >2XE4-A nrPDB Length = 751 Score = 33.2 bits (74), Expect = 0.29, Method: Composition-based stats. Identities = 24/173 (13%), Positives = 51/173 (29%), Gaps = 15/173 (8%) Query: 315 LRWAPDGRHLASGGNDNLV---NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVL 371 + W PD L D + VW G+ + + +H A + +N L Sbjct: 226 IVWGPDHTSLFYVTKDETLRENKVWRHVMGKLQSEDVCLYEEHNPLFSAFMYKAADTNTL 285 Query: 372 ATGGGTSD-RHIRIWNVCSGACLSAVD----AHSQV-CSILWSPHYKELISGHGFAQNQL 425 G + + + + ++ G + ++ V + +I + Sbjct: 286 CIGSQSPETAEVHLLDLRKGNAHNTLEIVRPREKGVRYDVQMHGTSHLVILTNEGGAVNH 345 Query: 426 VIWKYPTMAK---VAELKGHTSRVL--SLTMSPDGATVASAAADETLRLWRCF 473 + P L H+ V S+ + + V + R+W Sbjct: 346 KLLIAPRGQPSDWSHVLVDHSEDVFMESIAVRSN-YLVVAGRRAGLTRIWTMM 397 >5SUM-A nrPDB Length = 468 Score = 32.1 bits (71), Expect = 0.54, Method: Composition-based stats. Identities = 28/141 (19%), Positives = 52/141 (36%), Gaps = 17/141 (12%) Query: 136 KPQNAPEG---YQNRLKVLYS--QKATPGSSRKTCRYIPSLPDR-------ILDAPEIRN 183 P +G YQ +S K + RK I LP+R + DA Sbjct: 262 SPGKTEKGKLNYQFAAITRWSHLTKYSTQHGRKPFAQIDLLPNREPLSQMEVFDAKGENV 321 Query: 184 DYYLNLVD---WSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNY 240 L ++ NV+ +V+ + + G +L + + + + + +G Y Sbjct: 322 VSSLGNFQSETFNELNVITTDYKKNVFKFDGN-GRMLGKVGRDDITGSSTYIH-VHDGKY 379 Query: 241 LAVGTSSAEVQLWDVQQQKRL 261 L G V+++D++ K L Sbjct: 380 LLQGGLDRYVRIFDIKTNKML 400 >5JRK-A nrPDB Length = 756 Score = 31.3 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 23/157 (14%), Positives = 44/157 (28%), Gaps = 38/157 (24%) Query: 311 EVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE--GGWVPLQTFTQHQGAVKAVAWCPWQS 368 EV + + +GR + G+ + T + V Sbjct: 64 EVNEIALSDNGRLAIYAAE-----IADLDAGKPRSHIRIVDVETGRTKELLTV----DTI 114 Query: 369 NVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPH-------YKELISGHGFA 421 L + GT D + ++ G L +D ++ ++ +P+ G G Sbjct: 115 KSLRSVPGTQDWSALV-DLGEGQQLYRIDTEGKLLPLIVNPNPVPVGKADMSFPLGGGIR 173 Query: 422 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATV 458 + + I Y SPDG + Sbjct: 174 PSHIGILDY-------------------DWSPDGKWL 191 >5HAX-A nrPDB Length = 742 Score = 31.3 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 35/229 (15%), Positives = 74/229 (32%), Gaps = 43/229 (18%) Query: 170 SLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYI 229 ++PD++ + + + L ++ ++D+S++LW + +L+ E+ I Sbjct: 57 NIPDKVFEHL-NAGEVFTKLGLFAEIGYAWASIDSSLFLWD-YTHPNPELIGYEEATHTI 114 Query: 230 SSVAWIKE---------GNYLAVGTSSAEVQL----WDVQQQKRLRNMTSHSARV----G 272 ++VA + + L V T+S + L + + S V Sbjct: 115 TAVALVPPKPGVFVKTITHVLVVATTSEIILLGVSATPTPSGSKSLTLYSTRMSVHRGGS 174 Query: 273 SLSW-----NSYILSSGSRSGHIHHHDVRVAEHHVATLSG---HSQ--------EVCGLR 316 +S+ + I G IH + E ++ G HS + GL Sbjct: 175 DVSFIVGTKDGRIFLGGESDTDIHEIFYQQEERWFSSRCGKINHSHPFGSRQQEWLRGLY 234 Query: 317 WAPDGRHLASGGNDNLVNVWPSAP--------GEGGWVPLQTFTQHQGA 357 L S N + + + + L+ F + Sbjct: 235 VDDTRNLLYSLSNRSTIRTYHMEGPEKLTKVIEKDKTSCLRDFAHMADS 283 >4Q1V-A nrPDB Length = 710 Score = 30.9 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 21/142 (14%), Positives = 48/142 (33%), Gaps = 26/142 (18%) Query: 208 LWSASSGDILQLLQMEQPGEYISSVAWIKE--GNYLAVGTSSA---EVQLWDVQQQKRLR 262 +++ ++G + L + Y ++++W + YL ++ ++ + + + Sbjct: 222 IYNPATGKSIYLNAGDPTDRYFTNISWAPDEKSLYLIEVNRDQNHAKLCQYNAETGEPMG 281 Query: 263 NM--TSHSARVGS------LSWNSYILSSGS-RSG--HIHHHDVRVAEHHVATLSG---- 307 + H V L W+ S R G H++ + A T + Sbjct: 282 VLYEEMHPKYVEPQNPIVFLPWDPTKFIYQSQRDGYNHLYLFETNAANMKGETYNSANGG 341 Query: 308 ---HSQEVCGLRWAPDGRHLAS 326 + +V L G L S Sbjct: 342 SYFQAGKVKQL---TKGNWLVS 360 >1L9X-A nrPDB Length = 315 Score = 30.9 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 12/66 (18%), Positives = 25/66 (37%), Gaps = 14/66 (21%) Query: 260 RLRNMTSHSARVGSLSWNSYI-----LSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCG 314 N S V + + N + + + + G I ++T+ G+ V G Sbjct: 187 LTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKI---------EFISTMEGYKYPVYG 237 Query: 315 LRWAPD 320 ++W P+ Sbjct: 238 VQWHPE 243 >1FLG-A nrPDB Length = 582 Score = 29.7 bits (65), Expect = 2.6, Method: Composition-based stats. Identities = 17/87 (19%), Positives = 29/87 (33%), Gaps = 5/87 (5%) Query: 234 WIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVG-SLSW----NSYILSSGSRSG 288 GN + GT + +D + K L + S V ++W Y+ + G Sbjct: 493 LATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSPPITWEQDGEQYLGVTVGYGG 552 Query: 289 HIHHHDVRVAEHHVATLSGHSQEVCGL 315 + +A+ G S V L Sbjct: 553 AVPLWGGDMADLTRPVAQGGSFWVFKL 579 >5ODS-A nrPDB Length = 574 Score = 29.0 bits (63), Expect = 4.7, Method: Composition-based stats. Identities = 11/83 (13%), Positives = 32/83 (38%), Gaps = 7/83 (8%) Query: 231 SVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARV---GSLSWNSYILSSGSRS 287 A + + + + +Q+++++ + +++ T + V +S N+ L + Sbjct: 69 DSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTM-TDDVTFWKWISLNTVALVT---D 124 Query: 288 GHIHHHDVRVAEHHVATLSGHSQ 310 ++H + V HS Sbjct: 125 NAVYHWSMEGESQPVKMFDRHSS 147 >4G55-A nrPDB Length = 369 Score = 29.0 bits (63), Expect = 4.7, Method: Composition-based stats. Identities = 11/83 (13%), Positives = 32/83 (38%), Gaps = 7/83 (8%) Query: 231 SVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARV---GSLSWNSYILSSGSRS 287 A + + + + +Q+++++ + +++ T + V +S N+ L + Sbjct: 74 DSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTM-TDDVTFWKWISLNTVALVT---D 129 Query: 288 GHIHHHDVRVAEHHVATLSGHSQ 310 ++H + V HS Sbjct: 130 NAVYHWSMEGESQPVKMFDRHSS 152 >1BPO-A nrPDB Length = 494 Score = 29.0 bits (63), Expect = 4.7, Method: Composition-based stats. Identities = 11/83 (13%), Positives = 32/83 (38%), Gaps = 7/83 (8%) Query: 231 SVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARV---GSLSWNSYILSSGSRS 287 A + + + + +Q+++++ + +++ T + V +S N+ L + Sbjct: 69 DSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTM-TDDVTFWKWISLNTVALVT---D 124 Query: 288 GHIHHHDVRVAEHHVATLSGHSQ 310 ++H + V HS Sbjct: 125 NAVYHWSMEGESQPVKMFDRHSS 147 >1K3I-A nrPDB Length = 656 Score = 28.6 bits (62), Expect = 7.2, Method: Composition-based stats. Identities = 10/63 (15%), Positives = 20/63 (31%), Gaps = 3/63 (4%) Query: 405 ILWSPHYKELISGHGFAQNQLVIWKYPTM---AKVAELKGHTSRVLSLTMSPDGATVASA 461 ++WS + + G W T + + H ++M +G V + Sbjct: 201 LMWSSYRNDAFGGSPGGITLTSSWDPSTGIVSDRTVTVTKHDMFCPGISMDGNGQIVVTG 260 Query: 462 AAD 464 D Sbjct: 261 GND 263 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.125 0.344 Lambda K H 0.267 0.0383 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,564,699 Number of Sequences: 36641 Number of extensions: 721185 Number of successful extensions: 7208 Number of sequences better than 10.0: 170 Number of HSP's better than 10.0 without gapping: 253 Number of HSP's successfully gapped in prelim test: 64 Number of HSP's that attempted gapping in prelim test: 2187 Number of HSP's gapped (non-prelim): 1314 length of query: 499 length of database: 10,336,785 effective HSP length: 101 effective length of query: 398 effective length of database: 6,636,044 effective search space: 2641145512 effective search space used: 2641145512 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 61 (28.2 bits)