BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q12405 (387 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2Y6V-A nrPDB 812 0.0 6EIC-C nrPDB 41 9e-04 3P2M-A nrPDB 41 0.001 3C5W-P nrPDB 37 0.012 3JWE-A nrPDB 35 0.050 4HTA-A nrPDB 33 0.26 1U2E-A nrPDB 32 0.35 4UHD-A nrPDB 31 0.71 1UMS-A nrPDB 31 0.83 4ZOH-B nrPDB 30 1.7 2E3J-A nrPDB 30 1.9 3V1K-A nrPDB 29 2.7 1SLM-A nrPDB 29 3.0 3FCX-A nrPDB 28 5.2 3HQT-A nrPDB 28 7.4 6FKX-A nrPDB 28 7.9 1LGY-A nrPDB 28 8.2 >2Y6V-A nrPDB Length = 398 Score = 812 bits (2097), Expect = 0.0, Method: Compositional matrix adjust. Identities = 387/387 (100%), Positives = 387/387 (100%) Query: 1 MEQNRFKKETKTCSASWPRAPQSTLCATDRLELTYDVYTSAERQRRSRTATRLNLVFLHG 60 MEQNRFKKETKTCSASWPRAPQSTLCATDRLELTYDVYTSAERQRRSRTATRLNLVFLHG Sbjct: 1 MEQNRFKKETKTCSASWPRAPQSTLCATDRLELTYDVYTSAERQRRSRTATRLNLVFLHG 60 Query: 61 SGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNWIDGARD 120 SGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNWIDGARD Sbjct: 61 SGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNWIDGARD 120 Query: 121 VLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIEPVVITRKAIGA 180 VLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIEPVVITRKAIGA Sbjct: 121 VLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIEPVVITRKAIGA 180 Query: 181 GRPGLPPDSPQIPENLYNSLRLKTCDHFANESEYVKYMRNGSFFTNAHSQILQNIIDFER 240 GRPGLPPDSPQIPENLYNSLRLKTCDHFANESEYVKYMRNGSFFTNAHSQILQNIIDFER Sbjct: 181 GRPGLPPDSPQIPENLYNSLRLKTCDHFANESEYVKYMRNGSFFTNAHSQILQNIIDFER 240 Query: 241 TKASGDDEDGGPVRTKMEQAQNLLCYMNMQTFAPFLISNVKFVRKRTIHIVGARSNWCPP 300 TKASGDDEDGGPVRTKMEQAQNLLCYMNMQTFAPFLISNVKFVRKRTIHIVGARSNWCPP Sbjct: 241 TKASGDDEDGGPVRTKMEQAQNLLCYMNMQTFAPFLISNVKFVRKRTIHIVGARSNWCPP 300 Query: 301 QNQLFLQKTLQNYHLDVIPGGSHLVNVEAPDLVIERINHHIHEFVLTSPLQSSHIPQLTL 360 QNQLFLQKTLQNYHLDVIPGGSHLVNVEAPDLVIERINHHIHEFVLTSPLQSSHIPQLTL Sbjct: 301 QNQLFLQKTLQNYHLDVIPGGSHLVNVEAPDLVIERINHHIHEFVLTSPLQSSHIPQLTL 360 Query: 361 EERAVMFDRAFDSFKNEALVKTTKQKL 387 EERAVMFDRAFDSFKNEALVKTTKQKL Sbjct: 361 EERAVMFDRAFDSFKNEALVKTTKQKL 387 >6EIC-C nrPDB Length = 279 Score = 41.2 bits (95), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 49/173 (28%), Positives = 72/173 (41%), Gaps = 43/173 (24%) Query: 31 LELTYDVYTSAERQRRSRTATRLNLVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVL 90 + + YDV+T TA + +V HG G +++ RL AA YA+D Sbjct: 16 VRIVYDVWTP-------DTAPQAVVVLAHGLGEHARRYDHVAQRLGAAGLV-TYALD--- 64 Query: 91 LIDQVNHGDSA-----VRNRGRLGTNFNWIDGARDVLKIATCELGSIDSHPALN-VVIGH 144 HG S VR+ +F+ + G IAT E +P +V+GH Sbjct: 65 ---HRGHGRSGGKRVLVRDISEYTADFDTLVG------IATRE------YPGCKRIVLGH 109 Query: 145 SMGGFQALACDVLQPNLFHLLILIEP-----------VVITRKAIGAGRPGLP 186 SMGG A V +P+ + L++L P V + K +G PGLP Sbjct: 110 SMGGGIVFAYGVERPDNYDLMVLSAPAVAAQDLVSPVVAVAAKLLGVVVPGLP 162 >3P2M-A nrPDB Length = 330 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 33/125 (26%), Positives = 50/125 (40%), Gaps = 22/125 (17%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNW 114 ++FLHG G + W+ + L + L +D HG SA R G N Sbjct: 84 VIFLHGGGQNAHTWDTVIVGLG----------EPALAVDLPGHGHSAWREDGNYSPQLN- 132 Query: 115 IDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIE--PVV 172 + L EL P V+G S+GG A+ + P+L L+L++ P Sbjct: 133 ----SETLAPVLRELA-----PGAEFVVGMSLGGLTAIRLAAMAPDLVGELVLVDVTPSA 183 Query: 173 ITRKA 177 + R A Sbjct: 184 LQRHA 188 >3C5W-P nrPDB Length = 310 Score = 37.4 bits (85), Expect = 0.012, Method: Compositional matrix adjust. Identities = 30/115 (26%), Positives = 54/115 (46%), Gaps = 15/115 (13%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNW 114 L+ LHG G S + W + ++ + +++ +D +HG++ V+N L Sbjct: 45 LLLLHGGGHSALSWAVFTAAII------SRVQCRIVALDLRSHGETKVKNPEDLSAETM- 97 Query: 115 IDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQAL--ACDVLQPNLFHLLIL 167 A+DV + G + P ++IGH+MGG A+ A L P+L L ++ Sbjct: 98 ---AKDVGNVVEAMYGDL---PPPIMLIGHAMGGAIAVHTASSNLVPSLLGLCMI 146 >3JWE-A nrPDB Length = 320 Score = 35.0 bits (79), Expect = 0.050, Method: Compositional matrix adjust. Identities = 39/132 (29%), Positives = 59/132 (44%), Gaps = 24/132 (18%) Query: 49 TATRLNLVFL-HGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGR 107 T T L+F+ HG+G +E L+ D V D V HG S Sbjct: 55 TGTPKALIFVSHGAGEHSGRYEELARMLMGLDL-------LVFAHDHVGHGQS--EGERM 105 Query: 108 LGTNFNWIDGARDVLKIATCELGSIDS----HPALNV-VIGHSMGGFQALACDVLQPNLF 162 + ++F+ RDVL+ +DS +P L V ++GHSMGG A+ +P F Sbjct: 106 VVSDFHVF--VRDVLQ-------HVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHF 156 Query: 163 HLLILIEPVVIT 174 ++LI P+V+ Sbjct: 157 AGMVLISPLVLA 168 >4HTA-A nrPDB Length = 288 Score = 32.7 bits (73), Expect = 0.26, Method: Compositional matrix adjust. Identities = 30/121 (24%), Positives = 53/121 (43%), Gaps = 27/121 (22%) Query: 54 NLVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAV------RNRGR 107 +V HG G + VW++ +P LV +Y +V+L D + G + R Sbjct: 37 TIVLGHGFGTDQSVWKHLVPHLV-----DDY---RVVLYDNMGAGTTNPDYFDFDRYSNL 88 Query: 108 LGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLIL 167 G +F+ I D LKI +C + +GHS+ + + +P+LF +++ Sbjct: 89 EGYSFDLIAILED-LKIESC------------IFVGHSVSAMIGVLASLNRPDLFSKIVM 135 Query: 168 I 168 I Sbjct: 136 I 136 >1U2E-A nrPDB Length = 289 Score = 32.3 bits (72), Expect = 0.35, Method: Compositional matrix adjust. Identities = 38/144 (26%), Positives = 56/144 (38%), Gaps = 28/144 (19%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHG--DSAVRNRGRLGTNF 112 +V LHGSG W + R + E Y +V+L+D G DS V + R N Sbjct: 39 VVLLHGSGPGATGWANF-SRNIDPLVEAGY---RVILLDCPGWGKSDSVVNSGSRSDLNA 94 Query: 113 NWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIEPVV 172 + D L IA L +G+SMGG ++A + P L+L Sbjct: 95 RILKSVVDQLDIAKIHL------------LGNSMGGHSSVAFTLKWPERVGKLVL----- 137 Query: 173 ITRKAIGAGRPGLPPDSPQIPENL 196 +G G G+ +P E + Sbjct: 138 -----MGGGTGGMSLFTPMPTEGI 156 >4UHD-A nrPDB Length = 282 Score = 31.2 bits (69), Expect = 0.71, Method: Compositional matrix adjust. Identities = 17/59 (28%), Positives = 27/59 (45%), Gaps = 4/59 (6%) Query: 287 TIHIVGARSNWCPPQNQLFLQKTLQNYHLDVIPGGSHLVNVEAPDLVIERINHHIHEFV 345 T+ +VG PP+ + +T+ VIP HL +E P ER+ I E++ Sbjct: 214 TLVLVGQFDAISPPEEMEAMARTIPQSQFVVIPDAGHLPPMEQP----ERVTQAIREWL 268 >1UMS-A nrPDB Length = 174 Score = 31.2 bits (69), Expect = 0.83, Method: Compositional matrix adjust. Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 2/54 (3%) Query: 142 IGHSMGGFQALACDVLQPNLFHLLILIEPVVITRKAIGAGRP--GLPPDSPQIP 193 IGHS+G F + + L L+H L + +++ I + G PPDSP+ P Sbjct: 121 IGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETP 174 >4ZOH-B nrPDB Length = 278 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 18/66 (27%), Positives = 32/66 (48%), Gaps = 4/66 (6%) Query: 96 NHGDSAVRNRGRLGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACD 155 N GD VRN G +G + + +D + D L ++D+ + G + F++ A D Sbjct: 94 NIGDPQVRNMGTIGGSISHLDPSADY----PAALIAMDAKVKITSRKGDRVVNFKSFAKD 149 Query: 156 VLQPNL 161 + P+L Sbjct: 150 MFTPDL 155 >2E3J-A nrPDB Length = 356 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 34/133 (25%), Positives = 52/133 (39%), Gaps = 20/133 (15%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNW 114 +V LHG S W + +P L A +V+ IDQ +G S+ Sbjct: 30 VVLLHGFPESWYSWRHQIPALAGAGY-------RVVAIDQRGYGRSSKYR---------- 72 Query: 115 IDGARDVLKIATCELGSIDSHPALNV-VIGHSMGGFQALACDVLQPNLFHLLILIEPVVI 173 + A + ++ +G +DS+ A V+GH G A L P+ ++ I Sbjct: 73 VQKAYRIKELVGDVVGVLDSYGAEQAFVVGHDWGAPVAWTFAWLHPDRCAGVVGISVPFA 132 Query: 174 TRKAIGAGRPGLP 186 R IG PG P Sbjct: 133 GRGVIGL--PGSP 143 >3V1K-A nrPDB Length = 286 Score = 29.3 bits (64), Expect = 2.7, Method: Compositional matrix adjust. Identities = 34/118 (28%), Positives = 47/118 (39%), Gaps = 18/118 (15%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQ--VNHGDSAVRNRGRLGTNF 112 ++ LHG G W Y R V + Y +V+L D N D+ V + R N Sbjct: 36 VIMLHGGGPGAGGWSNYY-RNVGPFVDAGY---RVILKDSPGFNKSDAVVMDEQRGLVNA 91 Query: 113 NWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIEP 170 + G D L I L +G+SMGG AL + P+ LIL+ P Sbjct: 92 RAVKGLMDALDIDRAHL------------VGNSMGGATALNFALEYPDRIGKLILMGP 137 >1SLM-A nrPDB Length = 255 Score = 29.3 bits (64), Expect = 3.0, Method: Compositional matrix adjust. Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 2/52 (3%) Query: 142 IGHSMGGFQALACDVLQPNLFHLLILIEPVVITRKAIGAGRP--GLPPDSPQ 191 IGHS+G F + + L L+H L + +++ I + G PPDSP+ Sbjct: 203 IGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPE 254 >3FCX-A nrPDB Length = 282 Score = 28.5 bits (62), Expect = 5.2, Method: Compositional matrix adjust. Identities = 12/37 (32%), Positives = 17/37 (45%) Query: 136 PALNVVIGHSMGGFQALACDVLQPNLFHLLILIEPVV 172 P + GHSMGG AL C + P + + P+ Sbjct: 140 PQRMSIFGHSMGGHGALICALKNPGKYKSVSAFAPIC 176 >3HQT-A nrPDB Length = 409 Score = 28.1 bits (61), Expect = 7.4, Method: Compositional matrix adjust. Identities = 9/28 (32%), Positives = 18/28 (64%) Query: 317 VIPGGSHLVNVEAPDLVIERINHHIHEF 344 ++P GSH+ + PD + +I+H+I + Sbjct: 14 LVPRGSHMNKPQLPDFIQNKIDHYIENY 41 >6FKX-A nrPDB Length = 324 Score = 27.7 bits (60), Expect = 7.9, Method: Compositional matrix adjust. Identities = 14/42 (33%), Positives = 19/42 (45%) Query: 120 DVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNL 161 D ++A L D P G+S GG LAC L+P + Sbjct: 163 DTARLAQIVLAMDDVDPDRVAATGYSQGGGLTLACAALEPRI 204 >1LGY-A nrPDB Length = 269 Score = 27.7 bits (60), Expect = 8.2, Method: Compositional matrix adjust. Identities = 17/56 (30%), Positives = 29/56 (51%), Gaps = 4/56 (7%) Query: 132 IDSHPALNVVI-GHSMGGFQALACDVLQPNLFHLLILIEPVVITRKAIGAGRPGLP 186 + +HP V++ GHS+GG QAL + +L+ + P ++ +G R G P Sbjct: 131 LTAHPTYKVIVTGHSLGGAQALLAGM---DLYQREPRLSPKNLSIFTVGGPRVGNP 183 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2Y6V-A nrPDB 743 0.0 6EIC-C nrPDB 157 7e-39 3P2M-A nrPDB 136 1e-32 Sequences not found previously or not previously below threshold: 3JWE-A nrPDB 65 5e-11 2WUG-A nrPDB 45 5e-05 2E3J-A nrPDB 43 3e-04 1A88-A nrPDB 42 5e-04 1A8S-A nrPDB 42 5e-04 3C5W-P nrPDB 41 0.001 4NMW-A nrPDB 41 0.001 1CR6-A nrPDB 40 0.002 4UHD-A nrPDB 39 0.005 3KXP-A nrPDB 39 0.005 1M33-A nrPDB 38 0.008 3BF8-A nrPDB 37 0.020 1U2E-A nrPDB 36 0.027 3V1K-A nrPDB 36 0.028 4DGQ-A nrPDB 36 0.032 2PSJ-A nrPDB 36 0.033 4Y2Y-A nrPDB 35 0.048 4HTA-A nrPDB 35 0.062 3HEA-A nrPDB 35 0.077 5EGN-A nrPDB 34 0.088 4RNC-A nrPDB 34 0.11 2BKL-A nrPDB 34 0.11 1A8Q-A nrPDB 33 0.20 6AP7-A nrPDB 33 0.26 3O4I-A nrPDB 32 0.40 3HSS-A nrPDB 32 0.51 4GDM-A nrPDB 32 0.62 3WYD-A nrPDB 31 0.78 1EX9-A nrPDB 31 0.79 1R88-A nrPDB 31 0.90 3FOB-A nrPDB 31 1.0 4NVR-A nrPDB 31 1.1 3A2L-A nrPDB 30 1.4 3OM8-A nrPDB 30 2.2 2RON-A nrPDB 30 2.4 4IQ4-A nrPDB 29 2.5 4IH4-A nrPDB 29 2.7 1BRO-A nrPDB 29 3.0 3HQT-A nrPDB 29 3.3 5CJE-A nrPDB 29 3.9 1UMS-A nrPDB 29 3.9 3RLI-A nrPDB 28 6.1 6FKX-A nrPDB 28 6.5 3FLA-A nrPDB 28 6.5 3J9M-l nrPDB 28 7.7 1LGY-A nrPDB 28 9.4 >2Y6V-A nrPDB Length = 398 Score = 743 bits (1918), Expect = 0.0, Method: Composition-based stats. Identities = 387/387 (100%), Positives = 387/387 (100%) Query: 1 MEQNRFKKETKTCSASWPRAPQSTLCATDRLELTYDVYTSAERQRRSRTATRLNLVFLHG 60 MEQNRFKKETKTCSASWPRAPQSTLCATDRLELTYDVYTSAERQRRSRTATRLNLVFLHG Sbjct: 1 MEQNRFKKETKTCSASWPRAPQSTLCATDRLELTYDVYTSAERQRRSRTATRLNLVFLHG 60 Query: 61 SGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNWIDGARD 120 SGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNWIDGARD Sbjct: 61 SGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNWIDGARD 120 Query: 121 VLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIEPVVITRKAIGA 180 VLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIEPVVITRKAIGA Sbjct: 121 VLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIEPVVITRKAIGA 180 Query: 181 GRPGLPPDSPQIPENLYNSLRLKTCDHFANESEYVKYMRNGSFFTNAHSQILQNIIDFER 240 GRPGLPPDSPQIPENLYNSLRLKTCDHFANESEYVKYMRNGSFFTNAHSQILQNIIDFER Sbjct: 181 GRPGLPPDSPQIPENLYNSLRLKTCDHFANESEYVKYMRNGSFFTNAHSQILQNIIDFER 240 Query: 241 TKASGDDEDGGPVRTKMEQAQNLLCYMNMQTFAPFLISNVKFVRKRTIHIVGARSNWCPP 300 TKASGDDEDGGPVRTKMEQAQNLLCYMNMQTFAPFLISNVKFVRKRTIHIVGARSNWCPP Sbjct: 241 TKASGDDEDGGPVRTKMEQAQNLLCYMNMQTFAPFLISNVKFVRKRTIHIVGARSNWCPP 300 Query: 301 QNQLFLQKTLQNYHLDVIPGGSHLVNVEAPDLVIERINHHIHEFVLTSPLQSSHIPQLTL 360 QNQLFLQKTLQNYHLDVIPGGSHLVNVEAPDLVIERINHHIHEFVLTSPLQSSHIPQLTL Sbjct: 301 QNQLFLQKTLQNYHLDVIPGGSHLVNVEAPDLVIERINHHIHEFVLTSPLQSSHIPQLTL 360 Query: 361 EERAVMFDRAFDSFKNEALVKTTKQKL 387 EERAVMFDRAFDSFKNEALVKTTKQKL Sbjct: 361 EERAVMFDRAFDSFKNEALVKTTKQKL 387 >6EIC-C nrPDB Length = 279 Score = 157 bits (397), Expect = 7e-39, Method: Composition-based stats. Identities = 49/173 (28%), Positives = 72/173 (41%), Gaps = 43/173 (24%) Query: 31 LELTYDVYTSAERQRRSRTATRLNLVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVL 90 + + YDV+T TA + +V HG G +++ RL AA YA+D Sbjct: 16 VRIVYDVWTP-------DTAPQAVVVLAHGLGEHARRYDHVAQRLGAAGLV-TYALD--- 64 Query: 91 LIDQVNHGDSA-----VRNRGRLGTNFNWIDGARDVLKIATCELGSIDSHPALN-VVIGH 144 HG S VR+ +F+ + G IAT E +P +V+GH Sbjct: 65 ---HRGHGRSGGKRVLVRDISEYTADFDTLVG------IATRE------YPGCKRIVLGH 109 Query: 145 SMGGFQALACDVLQPNLFHLLILIEP-----------VVITRKAIGAGRPGLP 186 SMGG A V +P+ + L++L P V + K +G PGLP Sbjct: 110 SMGGGIVFAYGVERPDNYDLMVLSAPAVAAQDLVSPVVAVAAKLLGVVVPGLP 162 >3P2M-A nrPDB Length = 330 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 36/135 (26%), Positives = 54/135 (40%), Gaps = 24/135 (17%) Query: 45 RRSRTATRLNLVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRN 104 R +A R ++FLHG G + W+ + L + L +D HG SA R Sbjct: 76 RWGGSAPR--VIFLHGGGQNAHTWDTVIVGLG----------EPALAVDLPGHGHSAWRE 123 Query: 105 RGRLGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHL 164 G N + L EL P V+G S+GG A+ + P+L Sbjct: 124 DGNYSPQLN-----SETLAPVLRELA-----PGAEFVVGMSLGGLTAIRLAAMAPDLVGE 173 Query: 165 LILIE--PVVITRKA 177 L+L++ P + R A Sbjct: 174 LVLVDVTPSALQRHA 188 >3JWE-A nrPDB Length = 320 Score = 65.2 bits (157), Expect = 5e-11, Method: Composition-based stats. Identities = 43/178 (24%), Positives = 64/178 (35%), Gaps = 35/178 (19%) Query: 43 RQRRSRTATRLNLVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAV 102 R + + + HG+G +E L+ D V D V HG S Sbjct: 50 RYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLL-------VFAHDHVGHGQS-- 100 Query: 103 RNRGRLGTNFNWIDGARDVLKIATCELGSIDSHPALN-VVIGHSMGGFQALACDVLQPNL 161 G ++ RDVL+ +P L ++GHSMGG A+ +P Sbjct: 101 --EGERMVVSDFHVFVRDVLQHVD---SMQKDYPGLPVFLLGHSMGGAIAILTAAERPGH 155 Query: 162 FHLLILIEPV------------VITRKAIGAGRPGL---PPDSPQIPEN-----LYNS 199 F ++LI P+ V+ K + P L P DS + N +YNS Sbjct: 156 FAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNS 213 >2WUG-A nrPDB Length = 291 Score = 45.1 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 29/120 (24%), Positives = 47/120 (39%), Gaps = 15/120 (12%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNW 114 +V LHG G W + + + VL +DQ +G S R G FN Sbjct: 39 VVLLHGGGPGAASWTNFSRNIAVLARHFH-----VLAVDQPGYGHSDKR--AEHG-QFNR 90 Query: 115 IDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIEPVVIT 174 A LK +LG ++G+++GG A+ + P L+L+ P ++ Sbjct: 91 Y--AAMALKGLFDQLGLGRVP-----LVGNALGGGTAVRFALDYPARAGRLVLMGPGGLS 143 >2E3J-A nrPDB Length = 356 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 34/133 (25%), Positives = 51/133 (38%), Gaps = 20/133 (15%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNW 114 +V LHG S W + +P L A +V+ IDQ +G S + Sbjct: 30 VVLLHGFPESWYSWRHQIPALAGAGY-------RVVAIDQRGYGRS-----SKYRVQ--- 74 Query: 115 IDGARDVLKIATCELGSIDSHPALN-VVIGHSMGGFQALACDVLQPNLFHLLILIEPVVI 173 A + ++ +G +DS+ A V+GH G A L P+ ++ I Sbjct: 75 --KAYRIKELVGDVVGVLDSYGAEQAFVVGHDWGAPVAWTFAWLHPDRCAGVVGISVPFA 132 Query: 174 TRKAIGAGRPGLP 186 R IG PG P Sbjct: 133 GRGVIGL--PGSP 143 >1A88-A nrPDB Length = 275 Score = 42.0 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 42/221 (19%), Positives = 78/221 (35%), Gaps = 48/221 (21%) Query: 24 TLCATDRLELTYDVYTSAERQRRSRTATRLNLVFLHGSGMSKVVWEYYLPRLVAADAEGN 83 T+ +D + Y + + L +VF HG +S W+ + ++ Sbjct: 2 TVTTSDGTNIFYKDWGPRDG---------LPVVFHHGWPLSADDWDNQMLFFLSHGY--- 49 Query: 84 YAIDKVLLIDQVNHGDSAVRNRGRLGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIG 143 +V+ D+ HG S ++ G + + L A G++ IG Sbjct: 50 ----RVIAHDRRGHGRS---DQPSTGHDMDTYAADVAALTEALDLRGAVH--------IG 94 Query: 144 HSMGGFQALACDVLQPNLFHLLILIEPVVITRKAIGAGRPGLPPDSPQIPENLYNSLRLK 203 HS GG + EP + + + + P + S P+ L L+ Sbjct: 95 HSTGGGEVARYVARA----------EPGRVAKAVLVSAVPPVMVKSDTNPD----GLPLE 140 Query: 204 TCDHF-----ANESEYVKYMRNGSF--FTNAHSQILQNIID 237 D F AN +++ + +G F F + + Q +ID Sbjct: 141 VFDEFRAALAANRAQFYIDVPSGPFYGFNREGATVSQGLID 181 >1A8S-A nrPDB Length = 273 Score = 42.0 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 42/206 (20%), Positives = 76/206 (36%), Gaps = 46/206 (22%) Query: 23 STLCATDRLELTYDVYTSAERQRRSRTATRLNLVFLHGSGMSKVVWEYYLPRLVAADAEG 82 +T D ++ Y + S + +VF HG ++ WE + L A Sbjct: 1 TTFTTRDGTQIYYKDWGSGQP-----------IVFSHGWPLNADSWESQMIFLAAQGY-- 47 Query: 83 NYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNWIDGARDVLKIATCELGSIDSHPALNVVI 142 +V+ D+ HG S+ G N +D D L L D+ V+ Sbjct: 48 -----RVIAHDRRGHGRSSQPWSG------NDMDTYADDLAQLIEHLDLRDA-----VLF 91 Query: 143 GHSMGGFQALAC----DVLQPNLFHLLILIEPVVITRKAIGAGRPGLPPDSPQIPENLYN 198 G S GG + + L+ + P+++ +A PG +P +++ Sbjct: 92 GFSTGGGEVARYIGRHGTARVAKAGLISAVPPLMLKTEA----NPG------GLPMEVFD 141 Query: 199 SLRLKTCDHFANESEYVKYMRNGSFF 224 +R + A+ S+ K + +G FF Sbjct: 142 GIRQAS---LADRSQLYKDLASGPFF 164 >3C5W-P nrPDB Length = 310 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 32/116 (27%), Positives = 53/116 (45%), Gaps = 15/116 (12%) Query: 54 NLVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFN 113 L+ LHG G S + W V A + +++ +D +HG++ V+N L Sbjct: 44 VLLLLHGGGHSALSWA------VFTAAIISRVQCRIVALDLRSHGETKVKNPEDLSAE-- 95 Query: 114 WIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQAL--ACDVLQPNLFHLLIL 167 A+DV + G + P ++IGH+MGG A+ A L P+L L ++ Sbjct: 96 --TMAKDVGNVVEAMYGDL---PPPIMLIGHAMGGAIAVHTASSNLVPSLLGLCMI 146 >4NMW-A nrPDB Length = 259 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 29/136 (21%), Positives = 48/136 (35%), Gaps = 30/136 (22%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNW 114 LV LHG G++ VW L + L+D +G S + F Sbjct: 19 LVLLHGWGLNAEVWHCIREELGSHFTLH--------LVDLPGYGRS---------SGFGA 61 Query: 115 IDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIE--PVV 172 + ++A + P + +G S+GG A + P L+ + P Sbjct: 62 MTLEEMTAQVA-------KNAPDQAIWLGWSLGGLVASQMALTHPERVQALVTVASSPCF 114 Query: 173 ITRKAIGAGRPGLPPD 188 R+ G PG+ P+ Sbjct: 115 SARE----GWPGIKPE 126 >1CR6-A nrPDB Length = 554 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 38/191 (19%), Positives = 53/191 (27%), Gaps = 30/191 (15%) Query: 11 KTCSASWPRAPQSTLCATDRLELTYDVYTSAERQRRSRTATRLNLVFLHGSGMSKVVWEY 70 K +P AP C + + Y R + L HG S W Y Sbjct: 215 KVTGTQFPEAPLPVPCNPNDVSHGYVTVKPGIRLHFVEMGSGPALCLCHGFPESWFSWRY 274 Query: 71 YLPRLVAADAEGNYAIDKVLLIDQVNHGDSAV-RNRGRLGTNFNWIDGARDVLKIATCEL 129 +P L A +VL ID +GDS+ + +L Sbjct: 275 QIPALAQAGF-------RVLAIDMKGYGDSSSPPEIEEYAMEL-----LCKEMVTFLDKL 322 Query: 130 GSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIEPVVITRKAIGAGRPGLPPDS 189 G + V IGH G + P R P +PPD Sbjct: 323 GIPQA-----VFIGHDWAGVMVWNMALFYPERV------------RAVASLNTPFMPPDP 365 Query: 190 PQIPENLYNSL 200 P + S+ Sbjct: 366 DVSPMKVIRSI 376 >4UHD-A nrPDB Length = 282 Score = 38.6 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 66/321 (20%), Positives = 109/321 (33%), Gaps = 61/321 (19%) Query: 30 RLELTYDVYTSAERQRRSRTATRLNLVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKV 89 R+++T T T L ++ +HG + + +W+ A E +V Sbjct: 4 RVKITTTATPGEIELAFEDTGTGLPVLLVHGFPLDRTMWK--------AQREELCDEFRV 55 Query: 90 LLIDQVNHGDSAVRNRGRLGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGF 149 ++ D G+S V ++ D L LG V+ G SMGG+ Sbjct: 56 IVPDLRGFGESQV------IPGVATMEAMADDLAGLCNHLGLT----GKIVLGGLSMGGY 105 Query: 150 QALACDVLQPNLFHLLILIEPVVITRKAIGAGRPGLPPDSPQIPENLYNSLRLKTCD--H 207 A A + LIL + PDSP+ EN + Sbjct: 106 VAFAFARKYRDRLAGLILCDTRA-------------RPDSPEAKENRRRVAERVRREGPG 152 Query: 208 FANESEYVKYMRNGSFFTNAHSQILQNIIDFERTKASGDDEDGGPVRTKMEQ---AQNLL 264 F E E + + S F N H ++++ I + S E M + + +LL Sbjct: 153 FIAE-EMIPRLCCESTFRN-HPEVIEKI---RQMILSAPPEGVAAAALGMAERPDSTDLL 207 Query: 265 CYMNMQTFAPFLISNVKFVRKRTIHIVGARSNWCPPQNQLFLQKTLQNYHLDVIPGGSHL 324 ++ T +VG PP+ + +T+ VIP HL Sbjct: 208 PALSCPTLV----------------LVGQFDAISPPEEMEAMARTIPQSQFVVIPDAGHL 251 Query: 325 VNVEAPDLVIERINHHIHEFV 345 +E P ER+ I E++ Sbjct: 252 PPMEQP----ERVTQAIREWL 268 >3KXP-A nrPDB Length = 314 Score = 38.6 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 22/115 (19%), Positives = 42/115 (36%), Gaps = 19/115 (16%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNW 114 ++F HG + V+E + RL + +DQ HG S G ++ Sbjct: 71 MLFFHGITSNSAVFEPLMIRLSDRFT--------TIAVDQRGHGLSDKPETGYEANDY-- 120 Query: 115 IDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIE 169 D + L +++GHS+G ++ P+L ++ I+ Sbjct: 121 ----ADDIAGLIRTLAR-----GHAILVGHSLGARNSVTAAAKYPDLVRSVVAID 166 >1M33-A nrPDB Length = 258 Score = 37.8 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 31/136 (22%), Positives = 48/136 (35%), Gaps = 30/136 (22%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNW 114 LV LHG G++ VW R + + ++ + L+D G S R G Sbjct: 16 LVLLHGWGLNAEVW-----RCIDEELSSHFTLH---LVDLPGFGRS--RGFG-------- 57 Query: 115 IDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIE--PVV 172 L +A + P + +G S+GG A + P L+ + P Sbjct: 58 ------ALSLADMAEAVLQQAPDKAIWLGWSLGGLVASQIALTHPERVRALVTVASSPCF 111 Query: 173 ITRKAIGAGRPGLPPD 188 R PG+ PD Sbjct: 112 SARDEW----PGIKPD 123 >3BF8-A nrPDB Length = 255 Score = 36.6 bits (83), Expect = 0.020, Method: Composition-based stats. Identities = 19/89 (21%), Positives = 29/89 (32%), Gaps = 12/89 (13%) Query: 89 VLLIDQVNHGDSAVRNRGRLGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGG 148 ++ +D NHG S + D +I IGHSMGG Sbjct: 45 IIQVDVRNHGLSPREPVMNYPAMAQDLVDTLDAQQIDKATF------------IGHSMGG 92 Query: 149 FQALACDVLQPNLFHLLILIEPVVITRKA 177 +A L P+ L+ I+ + Sbjct: 93 KAVMALTALAPDRIDKLVAIDIAPVDYHV 121 >1U2E-A nrPDB Length = 289 Score = 35.9 bits (81), Expect = 0.027, Method: Composition-based stats. Identities = 27/114 (23%), Positives = 45/114 (39%), Gaps = 14/114 (12%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNW 114 +V LHGSG W + + G +V+L+D G S ++ N Sbjct: 39 VVLLHGSGPGATGWANFSRNIDPLVEAGY----RVILLDCPGWGKSDSVVNSGSRSDLN- 93 Query: 115 IDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILI 168 +LK +L H ++G+SMGG ++A + P L+L+ Sbjct: 94 ----ARILKSVVDQLDIAKIH-----LLGNSMGGHSSVAFTLKWPERVGKLVLM 138 >3V1K-A nrPDB Length = 286 Score = 35.9 bits (81), Expect = 0.028, Method: Composition-based stats. Identities = 31/118 (26%), Positives = 44/118 (37%), Gaps = 18/118 (15%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVN--HGDSAVRNRGRLGTNF 112 ++ LHG G W Y + G +V+L D D+ V + R N Sbjct: 36 VIMLHGGGPGAGGWSNYYRNVGPFVDAGY----RVILKDSPGFNKSDAVVMDEQRGLVNA 91 Query: 113 NWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIEP 170 + G D L I L +G+SMGG AL + P+ LIL+ P Sbjct: 92 RAVKGLMDALDIDRAHL------------VGNSMGGATALNFALEYPDRIGKLILMGP 137 >4DGQ-A nrPDB Length = 280 Score = 35.9 bits (81), Expect = 0.032, Method: Composition-based stats. Identities = 26/131 (19%), Positives = 48/131 (36%), Gaps = 27/131 (20%) Query: 24 TLCATDRLELTYDVYTSAERQRRSRTATRLNLVFLHGSGMSKVVWEYYLPRLVAADAEGN 83 T+ D +E+ Y + + + + F HG +S W+ L V Sbjct: 7 TVTTKDGVEIFYKDWGPRDAK---------VIHFHHGWPLSSDDWDAQLLFFVNKGF--- 54 Query: 84 YAIDKVLLIDQVNHGDSAVRNRGRLGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIG 143 +V+ D+ HG S+ G + +D D +LG+ + + +G Sbjct: 55 ----RVVAHDRRGHGRSSQVWDG------HDMDHYADDAAAVVEKLGTHGA-----MHVG 99 Query: 144 HSMGGFQALAC 154 HS GG + + Sbjct: 100 HSTGGGEVVRY 110 >2PSJ-A nrPDB Length = 319 Score = 35.9 bits (81), Expect = 0.033, Method: Composition-based stats. Identities = 20/120 (16%), Positives = 45/120 (37%), Gaps = 21/120 (17%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLG--TNF 112 ++FLHG+ S +W + +P + + + ++ D + G S G ++ Sbjct: 47 VIFLHGNATSSYLWRHVVPHI--------EPVARCIIPDLIGMGKSGKSGNGSYRLLDHY 98 Query: 113 NWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIEPVV 172 ++ ++L + P + +GH G A + ++ +E VV Sbjct: 99 KYLTAWFELLNL-----------PKKIIFVGHDWGAALAFHYAYEHQDRIKAIVHMESVV 147 >4Y2Y-A nrPDB Length = 561 Score = 35.1 bits (79), Expect = 0.048, Method: Composition-based stats. Identities = 29/146 (19%), Positives = 44/146 (30%), Gaps = 22/146 (15%) Query: 20 APQSTLCATDRLELTYDVYTSAERQRRSRTATRLNLVFLHGSGMSKVVWEYYLPRLVAAD 79 AP T C + Y R + + HG S W Y +P L A Sbjct: 226 APLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAG 285 Query: 80 AEGNYAIDKVLLIDQVNHGD-SAVRNRGRLGTNFNWIDGARDVLKIATCELGSIDSHPAL 138 +VL +D +G+ SA +++ E+ + L Sbjct: 286 Y-------RVLAMDMKGYGESSAPPEIEEY------------CMEVLCKEMVTFLDKLGL 326 Query: 139 N--VVIGHSMGGFQALACDVLQPNLF 162 + V IGH GG + P Sbjct: 327 SQAVFIGHDWGGMLVWYMALFYPERV 352 >4HTA-A nrPDB Length = 288 Score = 34.7 bits (78), Expect = 0.062, Method: Composition-based stats. Identities = 23/122 (18%), Positives = 44/122 (36%), Gaps = 19/122 (15%) Query: 52 RLNLVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSA--VRNRGRLG 109 +V HG G + VW++ +P LV Y D + G + + R Sbjct: 35 EATIVLGHGFGTDQSVWKHLVPHLVDDYRVVLY--------DNMGAGTTNPDYFDFDRYS 86 Query: 110 TNFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIE 169 ++G L +L + +GHS+ + + +P+LF +++I Sbjct: 87 ----NLEGYSFDLIAILEDLKIESC-----IFVGHSVSAMIGVLASLNRPDLFSKIVMIS 137 Query: 170 PV 171 Sbjct: 138 AS 139 >3HEA-A nrPDB Length = 271 Score = 34.7 bits (78), Expect = 0.077, Method: Composition-based stats. Identities = 38/187 (20%), Positives = 69/187 (36%), Gaps = 47/187 (25%) Query: 23 STLCATDRLELTYDVYTSAERQRRSRTATRLNLVFLHGSGMSKVVWEYYLPRLVAADAEG 82 ST A D ++ + + S + ++F HG + +WEY + L + Sbjct: 1 STFVAKDGTQIYFKDWGSGKP-----------VLFSHGWPLDADMWEYQMEYLSSRGY-- 47 Query: 83 NYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNWIDGARDVLKIATCELGSIDSHPALNVV- 141 + + D+ G S ++ G +++ ++ + H L V Sbjct: 48 -----RTIAFDRRGFGRS---DQPWTGNDYDTFAD----------DIAQLIEHLDLKEVT 89 Query: 142 -IGHSMGGFQALACDVLQPNLFHLLILIEPVVITRKAIGAGRP--GLPPDSPQ-IPENLY 197 +G SMGG H + +V+ +GA P G PD PQ +P +++ Sbjct: 90 LVGFSMGGGDVARYIAR-----HGSARVAGLVL----LGAVTPIFGQKPDYPQGVPLDVF 140 Query: 198 NSLRLKT 204 R KT Sbjct: 141 --ARFKT 145 >5EGN-A nrPDB Length = 271 Score = 34.3 bits (77), Expect = 0.088, Method: Composition-based stats. Identities = 37/170 (21%), Positives = 67/170 (39%), Gaps = 39/170 (22%) Query: 29 DRLELTYDVYTSAERQRRSRTATRLNLVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDK 88 D +++ YD Y +VFLH + +W Y A + Sbjct: 7 DGVKIYYDSYGEGVP-----------IVFLHPFSTNGGIW--YFQTFPFAQT------NH 47 Query: 89 VLLIDQVNHGDSAVRNRGRLGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGG 148 V++ID HG S + T ++ ++ A DV+ + + +D V +G+S+GG Sbjct: 48 VIVIDHRGHGRS-----DKPATGYSIMEHADDVVAVL--DALKVDRA----VFVGNSIGG 96 Query: 149 FQALACDVLQPN-LFHLLILIEPVVITRKAIGAGRPGLPPDSPQIPENLY 197 A+ ++ P + LIL + G+PP++ +N Y Sbjct: 97 MIAMQLNLDHPQRVIGNLILSSGTGLGE--------GMPPEAGAAFQNDY 138 >4RNC-A nrPDB Length = 310 Score = 34.0 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 25/100 (25%), Positives = 38/100 (38%), Gaps = 16/100 (16%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNW 114 LV LHG S W + AD +Y + + +D HG S G + NW Sbjct: 48 LVLLHGWAQSSQCWGEQVL----ADLAADYRL---IAVDLRGHGYSDAPESG-YDDSANW 99 Query: 115 IDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALAC 154 A DV + E + ++ +++G S GG Sbjct: 100 ---AGDVAAVLAAEGVTENA-----ILLGWSYGGLVICDY 131 >2BKL-A nrPDB Length = 695 Score = 34.0 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 29/123 (23%), Positives = 48/123 (39%), Gaps = 13/123 (10%) Query: 79 DAEGNYAIDKVLLIDQVNHGD--SAVRNRGRLGTNFNWIDGARDVLKIATCELGSIDSHP 136 DA G YA+ + G+ A + GRL N D D A + + P Sbjct: 473 DAGGVYAV-----ANLRGGGEYGKAWHDAGRLDKKQNVFD---DFHAAAEYLVQQKYTQP 524 Query: 137 ALNVVIGHSMGGFQALACDVLQPNLFHLLILIEPV--VITRKAIGAGRPGLPP-DSPQIP 193 + G S GG A +P L+ ++ P+ ++ G+GR +P + + P Sbjct: 525 KRLAIYGGSNGGLLVGAAMTQRPELYGAVVCAVPLLDMVRYHLFGSGRTWIPEYGTAEKP 584 Query: 194 ENL 196 E+ Sbjct: 585 EDF 587 >1A8Q-A nrPDB Length = 274 Score = 33.2 bits (74), Expect = 0.20, Method: Composition-based stats. Identities = 26/131 (19%), Positives = 44/131 (33%), Gaps = 30/131 (22%) Query: 25 LCAT-DRLELTYDVYTSAERQRRSRTATRLNLVFLHGSGMSKVVWEYYLPRLVAADAEGN 83 +C T D +E+ Y + +VF+HG ++ W+ L +V A G Sbjct: 2 ICTTRDGVEIFYKDWGQGRP-----------VVFIHGWPLNGDAWQDQLKAVVDAGYRG- 49 Query: 84 YAIDKVLLIDQVNHGDSAVRNRGRLGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIG 143 + D+ HG S G +F+ + L ++ Sbjct: 50 ------IAHDRRGHGHSTPVWDGY---DFDTFADDLNDLLTDLDLRDVT--------LVA 92 Query: 144 HSMGGFQALAC 154 HSMGG + Sbjct: 93 HSMGGGELARY 103 >6AP7-A nrPDB Length = 269 Score = 32.8 bits (73), Expect = 0.26, Method: Composition-based stats. Identities = 27/121 (22%), Positives = 39/121 (32%), Gaps = 27/121 (22%) Query: 54 NLVFLHGSGMSKVVWEYYLP------RLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGR 107 LV HG G + W LP R+V D +++ R Sbjct: 22 VLVLAHGFGTDQSAWNRILPFFLRDYRVVLYDLVCAGSVNPDFFD---------FRRYTT 72 Query: 108 LGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLIL 167 L + + D L I C +GHS+ + + +P LF LIL Sbjct: 73 LDPYVDDLLHILDALGIDQCAY------------VGHSVSAMIGILASIRRPELFSKLIL 120 Query: 168 I 168 I Sbjct: 121 I 121 >3O4I-A nrPDB Length = 582 Score = 32.0 bits (71), Expect = 0.40, Method: Composition-based stats. Identities = 21/115 (18%), Positives = 38/115 (33%), Gaps = 14/115 (12%) Query: 51 TRLNLVFLHGS--GMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNH-GDSAVRNRGR 107 +V +HG W+ + L AA + N+ G + R Sbjct: 359 PGPTVVLVHGGPFAEDSDSWDTFAASLAAAG----------FHVVMPNYRGSTGYGEEWR 408 Query: 108 LGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLF 162 L + G + + A + ++G+S GG+ L ++P LF Sbjct: 409 LKIIGDPCGGELEDVSAAAR-WARESGLASELYIMGYSYGGYMTLCALTMKPGLF 462 >3HSS-A nrPDB Length = 293 Score = 31.6 bits (70), Expect = 0.51, Method: Composition-based stats. Identities = 27/123 (21%), Positives = 44/123 (35%), Gaps = 20/123 (16%) Query: 48 RTATRLNLVFLHGSGMSKVVWE-YYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRG 106 T +VF+ G G + W + +P +AA + + D G + Sbjct: 39 DNGTGDPVVFIAGRGGAGRTWHPHQVPAFLAAGY-------RCITFDNRGIGAT------ 85 Query: 107 RLGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLI 166 F D + + ++D PA V+G SMG F A V+ P L + Sbjct: 86 ENAEGFTTQTMVADTAAL----IETLDIAPAR--VVGVSMGAFIAQELMVVAPELVSSAV 139 Query: 167 LIE 169 L+ Sbjct: 140 LMA 142 >4GDM-A nrPDB Length = 268 Score = 31.6 bits (70), Expect = 0.62, Method: Composition-based stats. Identities = 23/98 (23%), Positives = 36/98 (36%), Gaps = 21/98 (21%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNW 114 LVFLHG W+ +A L +D HG SA + + Sbjct: 33 LVFLHGFSGDCHEWQEV---------GEAFADYSRLYVDLPGHGGSA-------AISVDG 76 Query: 115 IDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQAL 152 D D+L+ +D ++G+S+GG A+ Sbjct: 77 FDDVTDLLRKTLVSYNILDFW-----LVGYSLGGRVAM 109 >3WYD-A nrPDB Length = 228 Score = 31.3 bits (69), Expect = 0.78, Method: Composition-based stats. Identities = 26/125 (20%), Positives = 43/125 (34%), Gaps = 16/125 (12%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNW 114 ++ LHG G + + R +I+ N G +GR + Sbjct: 40 VIALHGMGGDENSYFDSYQR-------------GAFMIEAENRGYIVACPKGRQPASMYV 86 Query: 115 IDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIEPVVIT 174 RDV+ + P + GHSMGG+ + + P++F L PV Sbjct: 87 GPAERDVMDVIAEVRRDYKIDPDRIYMTGHSMGGYGTWSIAMNHPDVFAAL---APVAGG 143 Query: 175 RKAIG 179 +G Sbjct: 144 GNPLG 148 >1EX9-A nrPDB Length = 285 Score = 31.3 bits (69), Expect = 0.79, Method: Composition-based stats. Identities = 21/88 (23%), Positives = 36/88 (40%), Gaps = 6/88 (6%) Query: 80 AEGNYAIDKVLLIDQVNHGDSAVRNRGRLG-----TNFNWIDGARDVLKIATCELGSIDS 134 A G D +L +D SA+R G + + + + L E+ ++ Sbjct: 13 AHGMLGFDNILGVDYWFGIPSALRRDGAQVYVTEVSQLDTSEVRGEQLLQQVEEIVALSG 72 Query: 135 HPALNVVIGHSMGGFQALACDVLQPNLF 162 P +N+ IGHS GG ++P+L Sbjct: 73 QPKVNL-IGHSHGGPTIRYVAAVRPDLI 99 >1R88-A nrPDB Length = 280 Score = 30.9 bits (68), Expect = 0.90, Method: Composition-based stats. Identities = 27/116 (23%), Positives = 40/116 (34%), Gaps = 11/116 (9%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRG-RLGTNFN 113 + FL G G V Y L A N+ + G S V G N Sbjct: 27 VAFLAG-GPHAV---YLLDAFNAGPDVSNWVTAGNAMNTLAGKGISVVAPAGGAYSMYTN 82 Query: 114 W-IDGARDVLKIATCEL-----GSIDSHPALNVVIGHSMGGFQALACDVLQPNLFH 163 W DG++ + EL + P + +G + GG+ A+A P+ F Sbjct: 83 WEQDGSKQWDTFLSAELPDWLAANRGLAPGGHAAVGAAQGGYGAMALAAFHPDRFG 138 >3FOB-A nrPDB Length = 281 Score = 30.9 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 22/100 (22%), Positives = 39/100 (39%), Gaps = 18/100 (18%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNW 114 +V +HG +S WEY +P LV A +V+ D+ G S+ G + Sbjct: 30 VVLIHGWPLSGRSWEYQVPALVEAGY-------RVITYDRRGFGKSSQPWEG-YEYDTFT 81 Query: 115 IDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALAC 154 D + + ++ + ++G SMGG + Sbjct: 82 SDLHQLLEQLELQNVT----------LVGFSMGGGEVARY 111 >4NVR-A nrPDB Length = 307 Score = 30.9 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 23/115 (20%), Positives = 32/115 (27%), Gaps = 14/115 (12%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNW 114 LV LHG + W P L V+L D +GDS ++ Sbjct: 43 LVLLHGHPQNHTTWRKVAPTLAQN--------HTVILPDLRGYGDS---DKPTSDPAHRT 91 Query: 115 IDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIE 169 I S A +GH GG + P+ I+ Sbjct: 92 YSKRTMAQDIVMLMDALGFSRFA---FVGHDRGGRVGHRLALDYPDRVTCCTFID 143 >3A2L-A nrPDB Length = 309 Score = 30.5 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 23/130 (17%), Positives = 45/130 (34%), Gaps = 23/130 (17%) Query: 41 AERQRRSRTATRLNLVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDS 100 A R+ ++ A ++FLHG+ S +W LP + + + D + G S Sbjct: 20 AYRETGAQDAP--VVLFLHGNPTSSHIWRNILPLVS--------PVAHCIAPDLIGFGQS 69 Query: 101 AVRNRG-RLGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQP 159 + R + ++D + + + L + D G A +P Sbjct: 70 GKPDIAYRFFDHVRYLDAFIEQRGVTSAYLVAQDW------------GTALAFHLAARRP 117 Query: 160 NLFHLLILIE 169 + L +E Sbjct: 118 DFVRGLAFME 127 >3OM8-A nrPDB Length = 266 Score = 29.7 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 23/128 (17%), Positives = 37/128 (28%), Gaps = 19/128 (14%) Query: 45 RRSRTATRLNLVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRN 104 R A + L + G + +W+ LP L Y D HG S+V Sbjct: 20 RLDGAAEKPLLALSNSIGTTLHMWDAQLPALTRHFRVLRY--------DARGHGASSV-- 69 Query: 105 RGRLGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHL 164 + + + L +H +G S+GG + P Sbjct: 70 ----PPGPYTLARLGEDVLELLDALEVRRAH-----FLGLSLGGIVGQWLALHAPQRIER 120 Query: 165 LILIEPVV 172 L+L Sbjct: 121 LVLANTSA 128 >2RON-A nrPDB Length = 242 Score = 29.7 bits (65), Expect = 2.4, Method: Composition-based stats. Identities = 20/94 (21%), Positives = 34/94 (36%), Gaps = 17/94 (18%) Query: 90 LLIDQVNHGDSAVRNRGRLGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGF 149 L + HG + I+ ++ + EL P V+ GHSMGG Sbjct: 43 LAAEPPGHG----------TNQTSAIEDLEELTDLYKQELNLRPDRPF--VLFGHSMGGM 90 Query: 150 QALACD--VLQPNLFHLLIL---IEPVVITRKAI 178 + + +F ++ I+P I RK + Sbjct: 91 ITFRLAQKLEREGIFPQAVIISAIQPPHIQRKKV 124 >4IQ4-A nrPDB Length = 456 Score = 29.3 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 26/108 (24%), Positives = 41/108 (37%), Gaps = 18/108 (16%) Query: 47 SRTATRLNLVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRG 106 T +V +HG +S WE R AA + Y +V+ D+ G S Sbjct: 19 EDHGTGTPVVLIHGFPLSGHSWE----RQSAALLDAGY---RVITYDRRGFGQS-----S 66 Query: 107 RLGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALAC 154 + T +++ A D L L D+ V++G SMG + Sbjct: 67 QPTTGYDYDTFAAD-LNTVLETLDLQDA-----VLVGFSMGTGEVARY 108 >4IH4-A nrPDB Length = 267 Score = 29.3 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 23/118 (19%), Positives = 35/118 (29%), Gaps = 21/118 (17%) Query: 54 NLVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLG---T 110 L HG G + W LP Y + ++ + R Sbjct: 21 ILFLAHGFGTDQSAWHLILPYFTQNYRVVLYDLVCAGSVN------PDYFDFNRYTTLDP 74 Query: 111 NFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILI 168 + + D L I C +GHS+ + + +P LF LILI Sbjct: 75 YVDDLLNIVDSLGIQNCAY------------VGHSVSAMIGIIASIRRPELFSKLILI 120 >1BRO-A nrPDB Length = 277 Score = 29.3 bits (64), Expect = 3.0, Method: Composition-based stats. Identities = 25/100 (25%), Positives = 40/100 (40%), Gaps = 18/100 (18%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNW 114 +V +HG +S WE R AA + Y +V+ D+ G S + T +++ Sbjct: 26 VVLIHGFPLSGHSWE----RQSAALLDAGY---RVITYDRRGFGQS-----SQPTTGYDY 73 Query: 115 IDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALAC 154 A D L L D+ V++G SMG + Sbjct: 74 DTFAAD-LNTVLETLDLQDA-----VLVGFSMGTGEVARY 107 >3HQT-A nrPDB Length = 409 Score = 28.9 bits (63), Expect = 3.3, Method: Composition-based stats. Identities = 9/28 (32%), Positives = 18/28 (64%) Query: 317 VIPGGSHLVNVEAPDLVIERINHHIHEF 344 ++P GSH+ + PD + +I+H+I + Sbjct: 14 LVPRGSHMNKPQLPDFIQNKIDHYIENY 41 >5CJE-A nrPDB Length = 393 Score = 28.9 bits (63), Expect = 3.9, Method: Composition-based stats. Identities = 21/106 (19%), Positives = 39/106 (36%), Gaps = 17/106 (16%) Query: 158 QPNLFHLLILIEPVVITRKAIGAGRPGLPPDSPQIPENLYNSLRLKTCDHFANESEYVKY 217 + +L P+ + + +G P I + +L + ++E Y Sbjct: 130 RADLVDSFAYPLPITVICELLGV---------PDIDRVTFRALSNEIVAPTGGDAELAAY 180 Query: 218 MRNGSFFTNAHSQILQNIIDFERTKASGDDEDGGPVRTKMEQAQNL 263 R ++ L +ID +R+ A DD G +RT+ E L Sbjct: 181 ERLAAY--------LDELIDDKRSTAPADDLLGDLIRTRAEDDDRL 218 >1UMS-A nrPDB Length = 174 Score = 28.9 bits (63), Expect = 3.9, Method: Composition-based stats. Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 2/54 (3%) Query: 142 IGHSMGGFQALACDVLQPNLFHLLILIEPVVITRKAIGAGRP--GLPPDSPQIP 193 IGHS+G F + + L L+H L + +++ I + G PPDSP+ P Sbjct: 121 IGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETP 174 >3RLI-A nrPDB Length = 270 Score = 28.2 bits (61), Expect = 6.1, Method: Composition-based stats. Identities = 28/145 (19%), Positives = 42/145 (28%), Gaps = 17/145 (11%) Query: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNW 114 ++ +HG + A V L HG T +W Sbjct: 43 VLLVHGFTGTPHSMRPLAEAYAKAGYT-------VCLPRLKGHGTH--YEDMERTTFHDW 93 Query: 115 IDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIEPVVIT 174 + + +I V G SMGG L P++ ++ + V I Sbjct: 94 VASVEEGYGWLKQRCQTI-------FVTGLSMGGTLTLYLAEHHPDICGIVPINAAVDIP 146 Query: 175 RKAIGAGRPG-LPPDSPQIPENLYN 198 A G G LP I +L N Sbjct: 147 AIAAGMTGGGELPRYLDSIGSDLKN 171 >6FKX-A nrPDB Length = 324 Score = 28.2 bits (61), Expect = 6.5, Method: Composition-based stats. Identities = 14/40 (35%), Positives = 18/40 (45%) Query: 120 DVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQP 159 D ++A L D P G+S GG LAC L+P Sbjct: 163 DTARLAQIVLAMDDVDPDRVAATGYSQGGGLTLACAALEP 202 >3FLA-A nrPDB Length = 267 Score = 28.2 bits (61), Expect = 6.5, Method: Composition-based stats. Identities = 25/118 (21%), Positives = 33/118 (27%), Gaps = 21/118 (17%) Query: 45 RRSRTAT--RLNLVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAV 102 RR A R LV L +G S + L A +VL + Sbjct: 11 RRFERAPDARARLVCLPHAGGSASFFFPLAKALAPAV--------EVLAVQYPG------ 56 Query: 103 RNRGRLGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPN 160 R R + I G + L G + GHSMG + P Sbjct: 57 RQDRRHEPPVDSIGGLTNRLLEVLRPFGDRPLA-----LFGHSMGAIIGYELALRMPE 109 >3J9M-l nrPDB Length = 138 Score = 27.8 bits (60), Expect = 7.7, Method: Composition-based stats. Identities = 18/81 (22%), Positives = 30/81 (37%), Gaps = 5/81 (6%) Query: 117 GARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIEPVVITRK 176 GA ++L AT + V+ G G + + P+ + +PV +T Sbjct: 17 GAWELLNPATSGRLLARDYAKKPVMKGAKSGKGAVTSEALKDPD-----VCTDPVQLTTY 71 Query: 177 AIGAGRPGLPPDSPQIPENLY 197 A+G D P P+ Y Sbjct: 72 AMGVNIYKEGQDVPLKPDAEY 92 >1LGY-A nrPDB Length = 269 Score = 27.8 bits (60), Expect = 9.4, Method: Composition-based stats. Identities = 17/57 (29%), Positives = 29/57 (50%), Gaps = 4/57 (7%) Query: 131 SIDSHPALNVVI-GHSMGGFQALACDVLQPNLFHLLILIEPVVITRKAIGAGRPGLP 186 + +HP V++ GHS+GG QAL + +L+ + P ++ +G R G P Sbjct: 130 QLTAHPTYKVIVTGHSLGGAQALLAGM---DLYQREPRLSPKNLSIFTVGGPRVGNP 183 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.319 0.128 0.366 Lambda K H 0.267 0.0391 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,014,149 Number of Sequences: 36641 Number of extensions: 593845 Number of successful extensions: 1496 Number of sequences better than 10.0: 53 Number of HSP's better than 10.0 without gapping: 24 Number of HSP's successfully gapped in prelim test: 49 Number of HSP's that attempted gapping in prelim test: 1450 Number of HSP's gapped (non-prelim): 79 length of query: 387 length of database: 10,336,785 effective HSP length: 99 effective length of query: 288 effective length of database: 6,709,326 effective search space: 1932285888 effective search space used: 1932285888 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 60 (27.8 bits)