BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q12309 (687 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5LJ5-S nrPDB 1404 0.0 5GMK-d nrPDB 573 e-164 5XJC-J nrPDB 449 e-126 3JB9-R nrPDB 229 4e-60 6ICZ-I nrPDB 53 5e-07 5JPZ-A nrPDB 52 6e-07 5CTQ-A nrPDB 52 8e-07 5JJW-A nrPDB 52 1e-06 5CTR-A nrPDB 52 1e-06 5JJX-A nrPDB 50 5e-06 5C9S-B nrPDB 48 2e-05 5NLG-A nrPDB 47 3e-05 6G90-D nrPDB 45 2e-04 6AHD-N nrPDB 45 2e-04 5OQL-E nrPDB 42 0.001 5IC8-A nrPDB 40 0.003 6B85-J nrPDB 39 0.011 6G70-A nrPDB 37 0.026 3JCM-G nrPDB 36 0.047 5WLC-LP nrPDB 33 0.33 2OOE-A nrPDB 33 0.40 5ZWN-T nrPDB 32 1.2 1T6M-A nrPDB 32 1.3 5BN7-A nrPDB 31 1.7 4YUS-A nrPDB 30 2.5 5A01-A nrPDB 30 2.8 2OND-A nrPDB 30 4.7 1AUO-A nrPDB 29 6.2 4HOQ-A nrPDB 29 7.9 4AEZ-C nrPDB 28 8.9 >5LJ5-S nrPDB Length = 687 Score = 1404 bits (3635), Expect = 0.0, Method: Compositional matrix adjust. Identities = 687/687 (100%), Positives = 687/687 (100%) Query: 1 MDTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKR 60 MDTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKR Sbjct: 1 MDTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKR 60 Query: 61 NRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARN 120 NRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARN Sbjct: 61 NRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARN 120 Query: 121 LMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQK 180 LMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQK Sbjct: 121 LMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQK 180 Query: 181 NWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSD 240 NWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSD Sbjct: 181 NWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSD 240 Query: 241 MEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEET 300 MEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEET Sbjct: 241 MEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEET 300 Query: 301 ISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAIVDSRPKELSKNVQW 360 ISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAIVDSRPKELSKNVQW Sbjct: 301 ISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAIVDSRPKELSKNVQW 360 Query: 361 KRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDV 420 KRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDV Sbjct: 361 KRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDV 420 Query: 421 PKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGEL 480 PKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGEL Sbjct: 421 PKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGEL 480 Query: 481 EENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLEL 540 EENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLEL Sbjct: 481 EENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLEL 540 Query: 541 NQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEEAIV 600 NQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEEAIV Sbjct: 541 NQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEEAIV 600 Query: 601 FFKEKDDKQGRLSILEALKDYEETYGTELDQETVKKRFPKVIKKVRLQNGVEEEFVDYIF 660 FFKEKDDKQGRLSILEALKDYEETYGTELDQETVKKRFPKVIKKVRLQNGVEEEFVDYIF Sbjct: 601 FFKEKDDKQGRLSILEALKDYEETYGTELDQETVKKRFPKVIKKVRLQNGVEEEFVDYIF 660 Query: 661 PDDIDDDKPKPSKFLELAKKWKQEQAL 687 PDDIDDDKPKPSKFLELAKKWKQEQAL Sbjct: 661 PDDIDDDKPKPSKFLELAKKWKQEQAL 687 >5GMK-d nrPDB Length = 687 Score = 573 bits (1477), Expect = e-164, Method: Compositional matrix adjust. Identities = 275/275 (100%), Positives = 275/275 (100%) Query: 1 MDTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKR 60 MDTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKR Sbjct: 1 MDTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKR 60 Query: 61 NRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARN 120 NRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARN Sbjct: 61 NRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARN 120 Query: 121 LMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQK 180 LMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQK Sbjct: 121 LMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQK 180 Query: 181 NWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSD 240 NWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSD Sbjct: 181 NWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSD 240 Query: 241 MEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWP 275 MEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWP Sbjct: 241 MEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWP 275 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 66/256 (25%), Positives = 114/256 (44%), Gaps = 28/256 (10%) Query: 293 DINSIEETISYKRK--MEYETILSNNAYDYDTWWLYLDL-ISESFPKQIMQTFEKAI-VD 348 DI +EE Y+R+ EYE L N D W Y I + ++ FE+A+ VD Sbjct: 36 DILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVD 95 Query: 349 SRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWL 408 S +I LW+RYI EL+++ L R I +P K+W Sbjct: 96 SS------------FIPLWIRYID-AELKVKCINHARNLMNRAIS-TLPR----VDKLWY 137 Query: 409 MYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQP 468 Y ++V R + K L P + +++ E++ K ++ VR+IY K++ P Sbjct: 138 KYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNGVREIYSKYVMAHP 197 Query: 469 SDLQIWSQYGELEENLGDWDRVRGIYTIALD-----ENSDFLTKEAKIVLLQKYITFETE 523 +Q W ++ E G+ + R +Y++A+D +N + L+ + +E Sbjct: 198 Q-MQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAA 256 Query: 524 SQEFEKARKLYRRYLE 539 QE+E++ LY+ +E Sbjct: 257 QQEYERSSALYQIAIE 272 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 35/151 (23%), Positives = 75/151 (49%), Gaps = 9/151 (5%) Query: 407 WLMYAKFLIRHDDVPKARKILGKAIGLCPK-AKTFKGYIELEVKLKEFDRVRKIYEKFIE 465 W+ YA+F I D+ +AR I +A+ + + YI+ E+K+K + R + + I Sbjct: 68 WIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAIS 127 Query: 466 FQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQ 525 P ++W +Y +EE+L + + VR +YT + + E + ++ FE + Sbjct: 128 TLPRVDKLWYKYLIVEESLNNVEIVRSLYT-------KWCSLEPGVNAWNSFVDFEIRQK 180 Query: 526 EFEKARKLYRRYLELNQYSPQSWIEFAMYQT 556 + R++Y +Y+ + Q+W+++ ++ Sbjct: 181 NWNGVREIYSKYV-MAHPQMQTWLKWVRFEN 210 >5XJC-J nrPDB Length = 848 Score = 449 bits (1156), Expect = e-126, Method: Compositional matrix adjust. Identities = 261/691 (37%), Positives = 411/691 (59%), Gaps = 56/691 (8%) Query: 7 TAVDTHVSAEQILRDVYKKG-QKARGSTNIDILDLEELREYQRRKRTEYEGYLKRNRLDM 65 + ++AEQ+LR+ ++ + I D EEL +Y+ RKR +E +++NR + Sbjct: 183 APAEVQITAEQLLREAKERELELLPPPPQQKITDEEELNDYKLRKRKTFEDNIRKNRTVI 242 Query: 66 GQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRA 125 WI+YAQ+E +++RARSI+ERAL VD I LW++Y + E+K + +NHARN+ +RA Sbjct: 243 SNWIKYAQWEESLKEIQRARSIYERALDVDYRNITLWLKYAEMEMKNRQVNHARNIWDRA 302 Query: 126 ISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNGV 185 I+TLPRV++ WYKY +EE L NV R ++ +W +P AW+S+++FE+R K + Sbjct: 303 ITTLPRVNQFWYKYTYMEEMLGNVAGARQVFERWMEWQPEEQAWHSYINFELRYKEVDRA 362 Query: 186 REIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAK 245 R IY ++V+ HP ++ W+K+ RFE +H R VY A++ + M+ Sbjct: 363 RTIYERFVLVHPDVKNWIKYARFEEKHAYFAHARKVYERAVEFFGD-------EHMD-EH 414 Query: 246 LVNSFAHWEAAQQEYERSSALYQIA---IEKWPSNQLLKAGLLDFEKQFGDINSIEETIS 302 L +FA +E Q+E+ER +Y+ A I K + +L K + FEK+FGD IE+ I Sbjct: 415 LYVAFAKFEENQKEFERVRVIYKYALDRISKQDAQELFKNYTI-FEKKFGDRRGIEDIIV 473 Query: 303 YKRKMEYETILSNNAYDYDTWWLYLDLI-SESFPKQIMQTFEKAIVDSRPKELSKNVQWK 361 KR+ +YE + N ++YD W+ YL L+ S++ + + + +E+AI + P + + WK Sbjct: 474 SKRRFQYEEEVKANPHNYDAWFDYLRLVESDAEAEAVREVYERAIANVPP--IQEKRHWK 531 Query: 362 RYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVP 421 RYIYLW+ Y Y ELE ++ +++Q + ++IPHK FTF+K+W++YA+F IR ++ Sbjct: 532 RYIYLWINYALYEELEAKDPERTRQVYQASL-ELIPHKKFTFAKMWILYAQFEIRQKNLS 590 Query: 422 KARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELE 481 AR+ LG +IG CPK K FK YIELE++L+EFDR RK+YEKF+EF P + W ++ ELE Sbjct: 591 LARRALGTSIGKCPKNKLFKVYIELELQLREFDRCRKLYEKFLEFGPENCTSWIKFAELE 650 Query: 482 ENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELN 541 LGD DR R IY +A+ + + + VL + YI FE E +E E+ R LYRR L+ Sbjct: 651 TILGDIDRARAIYELAISQPRLDMPE----VLWKSYIDFEIEQEETERTRNLYRRLLQRT 706 Query: 542 QYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEEAIVF 601 Q+ + WI FA ++ S+ E L + R+++EEA Sbjct: 707 QHV-KVWISFAQFELSSGKEGSL------------------------TKCRQIYEEANKT 741 Query: 602 FKEKDDKQGRLSILEALKDYEETYGTELDQETVKKRFPKVIK---KVRLQNGVE---EEF 655 + ++K+ RL +LE+ + +EE +GT D+E V K P+ +K KV+ +G + EE+ Sbjct: 742 MRNCEEKEERLMLLESWRSFEEEFGTASDKERVDKLMPEKVKKRRKVQTDDGSDAGWEEY 801 Query: 656 VDYIFPDDIDDDKPKPS-KFLELAKKWKQEQ 685 DYIFP+D + +P+ K L +AK WK++Q Sbjct: 802 FDYIFPEDAAN---QPNLKLLAMAKLWKKQQ 829 >3JB9-R nrPDB Length = 674 Score = 229 bits (583), Expect = 4e-60, Method: Compositional matrix adjust. Identities = 114/258 (44%), Positives = 165/258 (63%), Gaps = 10/258 (3%) Query: 36 DILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVD 95 +I DLEEL+E+Q RKR E+E ++RNRL MG W+RY Q+E++Q + RARS+FERAL VD Sbjct: 41 NITDLEELQEFQGRKRKEFEDAIRRNRLAMGHWMRYGQWELDQKEFARARSVFERALDVD 100 Query: 96 SSFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSL 155 S++IPLW++YI+ E+K + INHARNL +RA++ LPRVDKLWYKY+ +EE L N+ R + Sbjct: 101 STYIPLWLKYIECEMKNRNINHARNLFDRAVTQLPRVDKLWYKYVYMEEMLGNITGCRQV 160 Query: 156 YTKWCSLEPGVNAWNSFVDFEIRQKNWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNT 215 + +W EP N W S++ E R R IY ++V+ HP++ WL+W RFE GN Sbjct: 161 FERWLKWEPDENCWMSYIRMERRYHENERARGIYERFVVVHPEVTNWLRWARFEEECGNA 220 Query: 216 EFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWP 275 R VY AID + + + +FA +E Q+EYER+ +++ AI+ P Sbjct: 221 ANVRQVYLAAIDALG--------QEFLNERFFIAFAKFEIRQKEYERARTIFKYAIDFMP 272 Query: 276 SNQLLK--AGLLDFEKQF 291 ++ ++ FEKQF Sbjct: 273 RSKSMELYKEYTHFEKQF 290 Score = 66.2 bits (160), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 71/278 (25%), Positives = 124/278 (44%), Gaps = 37/278 (13%) Query: 293 DINSIEETISYKRKMEYETILSNNAYDYDTWWLY--LDLISESFPKQIMQTFEKAI-VDS 349 D+ ++E KRK E+E + N W Y +L + F + FE+A+ VDS Sbjct: 44 DLEELQEFQGRKRK-EFEDAIRRNRLAMGHWMRYGQWELDQKEFAR-ARSVFERALDVDS 101 Query: 350 RPKELSKNVQWKRYIYLWMRYICYVELELENSLLEE--ELFQRLIDDIIPHKHFTFSKIW 407 YI LW++YI E E++N + LF R + + P K+W Sbjct: 102 T------------YIPLWLKYI---ECEMKNRNINHARNLFDRAVTQL-PR----VDKLW 141 Query: 408 LMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQ 467 Y ++ R++ + + P + YI +E + E +R R IYE+F+ Sbjct: 142 YKYVYMEEMLGNITGCRQVFERWLKWEPDENCWMSYIRMERRYHENERARGIYERFVVVH 201 Query: 468 PSDLQIWSQYGELEENLGDWDRVRGIYTIALDE-NSDFLTKEAKIVLLQKYITFETESQE 526 P ++ W ++ EE G+ VR +Y A+D +FL + I + FE +E Sbjct: 202 P-EVTNWLRWARFEEECGNAANVRQVYLAAIDALGQEFLNERFFIA----FAKFEIRQKE 256 Query: 527 FEKARKLYRRYLELNQYSPQSWIEFAMYQTSTPTEQQL 564 +E+AR +++ ++ + P+S +Y+ T E+Q Sbjct: 257 YERARTIFKYAID---FMPRS-KSMELYKEYTHFEKQF 290 Score = 34.3 bits (77), Expect = 0.17, Method: Compositional matrix adjust. Identities = 50/255 (19%), Positives = 100/255 (39%), Gaps = 34/255 (13%) Query: 199 MQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQ 258 M W+++ ++E RSV+ A+D D L + E + Sbjct: 70 MGHWMRYGQWELDQKEFARARSVFERALDV-----------DSTYIPLWLKYIECEMKNR 118 Query: 259 EYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAY 318 + L+ A+ + P L + E+ G+I + ++R +++E Sbjct: 119 NINHARNLFDRAVTQLPRVDKLWYKYVYMEEMLGNITGCRQV--FERWLKWEP------- 169 Query: 319 DYDTWWLYLDLISESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELEL 378 D + W Y+ + + + + V P E++ ++W R+ E E Sbjct: 170 DENCWMSYIRMERRYHENERARGIYERFVVVHP-EVTNWLRWARF-----------EEEC 217 Query: 379 ENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAK 438 N+ +++ ID + + F + ++ +AKF IR + +AR I AI P++K Sbjct: 218 GNAANVRQVYLAAIDAL--GQEFLNERFFIAFAKFEIRQKEYERARTIFKYAIDFMPRSK 275 Query: 439 TFKGYIELEVKLKEF 453 + + Y E K+F Sbjct: 276 SMELYKEYTHFEKQF 290 >6ICZ-I nrPDB Length = 855 Score = 52.8 bits (125), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 104/498 (20%), Positives = 203/498 (40%), Gaps = 88/498 (17%) Query: 68 WIRYAQFEIEQHDMRRARSIFERALLV-----DSSFIPLWIRYIDAE-LKVKCINHARNL 121 W+ Y QF ++Q + R F+RAL S PL++R++ + L + R Sbjct: 113 WLDYCQFLMDQGRVTHTRRTFDRALRALPITQHSRIWPLYLRFLRSHPLPETAVRGYRRF 172 Query: 122 MNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYT-----KWCSLEPGVN--AWNSFVD 174 + + P + + +YL + L+ E + L T ++ S N W+ D Sbjct: 173 LKLS----PESAEEYIEYLKSSDRLD--EAAQRLATVVNDERFVSKAGKSNYQLWHELCD 226 Query: 175 F------EIRQKNWNGVREIYSKYVMAHPQM-QTWLKWVRFENRHGNTEFTRSVYSLAID 227 +++ N + + I Q+ + W + R G+ E R VY AI Sbjct: 227 LISQNPDKVQSLNVDAI--IRGGLTRFTDQLGKLWCSLADYYIRSGHFEKARDVYEEAIR 284 Query: 228 TVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDF 287 TV +++ ++ +S+A +E + IA + +++L + D Sbjct: 285 TVMTVRDF--------TQVFDSYAQFEESM-----------IAAKMETASELGREEEDDV 325 Query: 288 EKQFGDINSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAIV 347 + + + E+ IS + + +L N + W + L + P++I+ T+ +A+ Sbjct: 326 DLEL-RLARFEQLISRRPLLLNSVLLRQNPHHVHEWHKRVAL-HQGRPREIINTYTEAVQ 383 Query: 348 DSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFT----F 403 P + + LW+ + + E +N L++ R+I + +F Sbjct: 384 TVDPFKATGKPH-----TLWVAFAKFYE---DNGQLDD---ARVILEKATKVNFKQVDDL 432 Query: 404 SKIWLMYAKFLIRHDDVPKARKILGKAIGL-CPKAKTFKGYIELEVKLKEFDRVRKIYEK 462 + +W + +RH++ +A ++L KA L +A+ F G ++ +RV K Sbjct: 433 ASVWCQCGELELRHENYDEALRLLRKATALPARRAEYFDGSEPVQ------NRVYK---- 482 Query: 463 FIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFET 522 L++WS +LEE+LG + + +Y D D +IV+ Y F Sbjct: 483 -------SLKVWSMLADLEESLGTFQSTKAVY----DRILDLRIATPQIVI--NYAMFLE 529 Query: 523 ESQEFEKARKLYRRYLEL 540 E + FE++ K Y R + L Sbjct: 530 EHKYFEESFKAYERGISL 547 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 31/129 (24%), Positives = 63/129 (48%), Gaps = 9/129 (6%) Query: 68 WIRYAQFEIEQHDMRRARSIFERALLV--DSSFIPLWIRYIDAELKVKCINHARNLMNRA 125 ++ YAQ E E R A +++ERA + ++ YI ++ + H R + +A Sbjct: 596 YLLYAQLEEEWGLARHAMAVYERATRAVEPAQQYDMFNIYIKRAAEIYGVTHTRGIYQKA 655 Query: 126 ISTLP--RVDKLWYKYLIVEESLNNVEIVRSLYTKWCS--LEPGVNA--WNSFVDFEIRQ 179 I L ++ ++ +E L ++ R++Y+ +CS +P W ++ DFE+R Sbjct: 656 IEVLSDEHAREMCLRFADMECKLGEIDRARAIYS-FCSQICDPRTTGAFWQTWKDFEVRH 714 Query: 180 KNWNGVREI 188 N + ++E+ Sbjct: 715 GNEDTIKEM 723 Score = 37.7 bits (86), Expect = 0.015, Method: Compositional matrix adjust. Identities = 35/141 (24%), Positives = 52/141 (36%), Gaps = 27/141 (19%) Query: 99 IPLWIRYIDAELKVKCINHARN-LMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYT 157 + W+RYI E K N L RA+ LP KLWY+YL R+ Sbjct: 35 VKCWLRYI--EFKQGAPKPRLNQLYERALKLLPCSYKLWYRYLKAR---------RAQVK 83 Query: 158 KWCSLEPGVNAWNSFVDFEIRQKNWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEF 217 C +P ++ N E +V H + WL + +F G Sbjct: 84 HRCVTDPAY-------------EDVNNCHE--RAFVFMHKMPRLWLDYCQFLMDQGRVTH 128 Query: 218 TRSVYSLAIDTVANLQNLQIW 238 TR + A+ + Q+ +IW Sbjct: 129 TRRTFDRALRALPITQHSRIW 149 Score = 35.4 bits (80), Expect = 0.085, Method: Compositional matrix adjust. Identities = 43/196 (21%), Positives = 80/196 (40%), Gaps = 18/196 (9%) Query: 386 ELFQRLIDDIIPHKHFTFSKIWLMYAKF-----LIRHDDVPKARKILGKAIGLCPKAKTF 440 +LF++ +D P T ++L+YA+ L RH R +A+ + F Sbjct: 578 DLFEQALDGCPPKYAKT---LYLLYAQLEEEWGLARHAMAVYERAT--RAVEPAQQYDMF 632 Query: 441 KGYIELEVKLKEFDRVRKIYEKFIEFQPSD--LQIWSQYGELEENLGDWDRVRGIYTIAL 498 YI+ ++ R IY+K IE + ++ ++ ++E LG+ DR R IY+ Sbjct: 633 NIYIKRAAEIYGVTHTRGIYQKAIEVLSDEHAREMCLRFADMECKLGEIDRARAIYSFC- 691 Query: 499 DENSDFLTKEAKIVLLQKYITFETESQEFEKARKLY--RRYLELNQYSPQSWIEFAMYQT 556 S Q + FE + +++ RR ++ + +++ M + Sbjct: 692 ---SQICDPRTTGAFWQTWKDFEVRHGNEDTIKEMLRIRRSVQATYNTQVNFMASQMLKV 748 Query: 557 STPTEQQLLDLAKLQS 572 S + DLA QS Sbjct: 749 SGSATGTVSDLAPGQS 764 >5JPZ-A nrPDB Length = 509 Score = 52.4 bits (124), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 40/131 (30%), Positives = 67/131 (51%), Gaps = 13/131 (9%) Query: 55 EGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIP-LWIR---YIDAEL 110 E L+ + ++ Y FE++ D R + IFERA LV++ +P LWIR Y+D +L Sbjct: 235 EALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERA-LVENCLVPDLWIRYSQYLDRQL 293 Query: 111 KVKCINHARNLMNRAISTLPRVDKLWYKYLI------VEESLNNVEIVRSLYTKWCSLEP 164 KVK + ++ NRAI P LW +YL+ V+ + +V ++L + Sbjct: 294 KVK--DLVLSVHNRAIRNCPWTVALWSRYLLAMERHGVDHQVISVTFEKALNAGFIQATD 351 Query: 165 GVNAWNSFVDF 175 V W +++D+ Sbjct: 352 YVEIWQAYLDY 362 >5CTQ-A nrPDB Length = 561 Score = 52.0 bits (123), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 40/131 (30%), Positives = 67/131 (51%), Gaps = 13/131 (9%) Query: 55 EGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIP-LWIR---YIDAEL 110 E L+ + ++ Y FE++ D R + IFERA LV++ +P LWIR Y+D +L Sbjct: 250 EALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERA-LVENCLVPDLWIRYSQYLDRQL 308 Query: 111 KVKCINHARNLMNRAISTLPRVDKLWYKYLI------VEESLNNVEIVRSLYTKWCSLEP 164 KVK + ++ NRAI P LW +YL+ V+ + +V ++L + Sbjct: 309 KVK--DLVLSVHNRAIRNCPWTVALWSRYLLAMERHGVDHQVISVTFEKALNAGFIQATD 366 Query: 165 GVNAWNSFVDF 175 V W +++D+ Sbjct: 367 YVEIWQAYLDY 377 >5JJW-A nrPDB Length = 300 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 40/131 (30%), Positives = 67/131 (51%), Gaps = 13/131 (9%) Query: 55 EGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIP-LWIR---YIDAEL 110 E L+ + ++ Y FE++ D R + IFERA LV++ +P LWIR Y+D +L Sbjct: 22 EALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERA-LVENCLVPDLWIRYSQYLDRQL 80 Query: 111 KVKCINHARNLMNRAISTLPRVDKLWYKYLI------VEESLNNVEIVRSLYTKWCSLEP 164 KVK + ++ NRAI P LW +YL+ V+ + +V ++L + Sbjct: 81 KVK--DLVLSVHNRAIRNCPWTVALWSRYLLAMERHGVDHQVISVTFEKALNAGFIQATD 138 Query: 165 GVNAWNSFVDF 175 V W +++D+ Sbjct: 139 YVEIWQAYLDY 149 >5CTR-A nrPDB Length = 338 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 40/131 (30%), Positives = 67/131 (51%), Gaps = 13/131 (9%) Query: 55 EGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIP-LWIR---YIDAEL 110 E L+ + ++ Y FE++ D R + IFERA LV++ +P LWIR Y+D +L Sbjct: 27 EALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERA-LVENCLVPDLWIRYSQYLDRQL 85 Query: 111 KVKCINHARNLMNRAISTLPRVDKLWYKYLI------VEESLNNVEIVRSLYTKWCSLEP 164 KVK + ++ NRAI P LW +YL+ V+ + +V ++L + Sbjct: 86 KVK--DLVLSVHNRAIRNCPWTVALWSRYLLAMERHGVDHQVISVTFEKALNAGFIQATD 143 Query: 165 GVNAWNSFVDF 175 V W +++D+ Sbjct: 144 YVEIWQAYLDY 154 >5JJX-A nrPDB Length = 314 Score = 49.7 bits (117), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 35/94 (37%), Positives = 52/94 (55%), Gaps = 7/94 (7%) Query: 55 EGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIP-LWIR---YIDAEL 110 E L+ + ++ Y FE++ D R + IFERA LV++ +P LWIR Y+D +L Sbjct: 221 EALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERA-LVENCLVPDLWIRYSQYLDRQL 279 Query: 111 KVKCINHARNLMNRAISTLPRVDKLWYKYLIVEE 144 KVK + ++ NRAI P LW +YL+ E Sbjct: 280 KVK--DLVLSVHNRAIRNCPWTVALWSRYLLAME 311 >5C9S-B nrPDB Length = 572 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 40/196 (20%), Positives = 84/196 (42%), Gaps = 18/196 (9%) Query: 88 FERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTL---PRVDKL--WYKYLIV 142 FER L+ + + +W+ Y+ +L++ I AR L RA+ T+ +KL W L + Sbjct: 307 FERLLIGNPNSSVVWMNYMAFQLQLSEIEKARELAERALKTINFREEAEKLNIWIAMLNL 366 Query: 143 EESLNNVEIVRSLYTKWCSLEPGVNAWNSFVD-FEIRQKNWNGVREIYSKYV--MAHPQM 199 E + E + ++++ C + +EI +K ++ E++ ++ Sbjct: 367 ENTFGTEETLEEVFSRACQYMDSYTIHTKLLGIYEISEK-FDKAAELFKATAKKFGGEKV 425 Query: 200 QTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQE 259 W+ W F H + R++ A+ + ++++ V FA E A+ + Sbjct: 426 SIWVSWGDFLISHNEEQEARTILGNALKALPKRNHIEV---------VRKFAQLEFAKGD 476 Query: 260 YERSSALYQIAIEKWP 275 ER +L++ + P Sbjct: 477 PERGRSLFEGLVADAP 492 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 25/92 (27%), Positives = 47/92 (51%), Gaps = 3/92 (3%) Query: 406 IWLMYAKFLIRHDDVPKARKILGKAIGLCPK---AKTFKGYIELEVKLKEFDRVRKIYEK 462 IW+ + FLI H++ +AR ILG A+ PK + + + +LE + +R R ++E Sbjct: 427 IWVSWGDFLISHNEEQEARTILGNALKALPKRNHIEVVRKFAQLEFAKGDPERGRSLFEG 486 Query: 463 FIEFQPSDLQIWSQYGELEENLGDWDRVRGIY 494 + P + +W+ Y + E D +V ++ Sbjct: 487 LVADAPKRIDLWNVYVDQEVKAKDKKKVEDLF 518 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 32/109 (29%), Positives = 55/109 (50%), Gaps = 8/109 (7%) Query: 59 KRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHA 118 KRN +++ + ++AQ E + D R RS+FE + I LW Y+D E+K K Sbjct: 457 KRNHIEVVR--KFAQLEFAKGDPERGRSLFEGLVADAPKRIDLWNVYVDQEVKAKDKKKV 514 Query: 119 RNLMNRAIS---TLPRVDKLWYKYLIVEESLNN---VEIVRSLYTKWCS 161 +L R I+ T + + K+L EES + +E V++ T++ + Sbjct: 515 EDLFERIITKKITRKQAKFFFNKWLQFEESEGDEKTIEYVKAKATEYVA 563 Score = 37.0 bits (84), Expect = 0.026, Method: Compositional matrix adjust. Identities = 42/188 (22%), Positives = 79/188 (42%), Gaps = 14/188 (7%) Query: 68 WIRYAQFEIEQHDMRRARSIFERALLV-----DSSFIPLWIRYIDAELKVKCINHARNLM 122 W+ Y F+++ ++ +AR + ERAL ++ + +WI ++ E + Sbjct: 321 WMNYMAFQLQLSEIEKARELAERALKTINFREEAEKLNIWIAMLNLENTFGTEETLEEVF 380 Query: 123 NRAISTLPRV---DKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQ 179 +RA + KL Y I E+ E+ ++ K+ + V+ W S+ DF I Sbjct: 381 SRACQYMDSYTIHTKLLGIYEISEKFDKAAELFKATAKKFGGEK--VSIWVSWGDFLISH 438 Query: 180 KNWNGVREIYSKYVMAHPQ---MQTWLKWVRFENRHGNTEFTRSVY-SLAIDTVANLQNL 235 R I + A P+ ++ K+ + E G+ E RS++ L D + Sbjct: 439 NEEQEARTILGNALKALPKRNHIEVVRKFAQLEFAKGDPERGRSLFEGLVADAPKRIDLW 498 Query: 236 QIWSDMEV 243 ++ D EV Sbjct: 499 NVYVDQEV 506 >5NLG-A nrPDB Length = 314 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 25/92 (27%), Positives = 47/92 (51%), Gaps = 3/92 (3%) Query: 406 IWLMYAKFLIRHDDVPKARKILGKAIGLCPK---AKTFKGYIELEVKLKEFDRVRKIYEK 462 IW+ + FLI H++ +AR ILG A+ PK + + + +LE + +R R ++E Sbjct: 177 IWVSWGDFLISHNEEQEARTILGNALKALPKRNHIEVVRKFAQLEFAKGDPERGRSLFEG 236 Query: 463 FIEFQPSDLQIWSQYGELEENLGDWDRVRGIY 494 + P + +W+ Y + E D +V ++ Sbjct: 237 LVADAPKRIDLWNVYVDQEVKAKDKKKVEDLF 268 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 40/196 (20%), Positives = 84/196 (42%), Gaps = 18/196 (9%) Query: 88 FERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTL---PRVDKL--WYKYLIV 142 FER L+ + + +W+ Y+ +L++ I AR L RA+ T+ +KL W L + Sbjct: 57 FERLLIGNPNSSVVWMNYMAFQLQLSEIEKARELAERALKTINFREEAEKLNIWIAMLNL 116 Query: 143 EESLNNVEIVRSLYTKWCSLEPGVNAWNSFVD-FEIRQKNWNGVREIYSKYV--MAHPQM 199 E + E + ++++ C + +EI +K ++ E++ ++ Sbjct: 117 ENTFGTEETLEEVFSRACQYMDSYTIHTKLLGIYEISEK-FDKAAELFKATAKKFGGEKV 175 Query: 200 QTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQE 259 W+ W F H + R++ A+ + ++++ V FA E A+ + Sbjct: 176 SIWVSWGDFLISHNEEQEARTILGNALKALPKRNHIEV---------VRKFAQLEFAKGD 226 Query: 260 YERSSALYQIAIEKWP 275 ER +L++ + P Sbjct: 227 PERGRSLFEGLVADAP 242 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 32/109 (29%), Positives = 55/109 (50%), Gaps = 8/109 (7%) Query: 59 KRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHA 118 KRN +++ + ++AQ E + D R RS+FE + I LW Y+D E+K K Sbjct: 207 KRNHIEVVR--KFAQLEFAKGDPERGRSLFEGLVADAPKRIDLWNVYVDQEVKAKDKKKV 264 Query: 119 RNLMNRAIS---TLPRVDKLWYKYLIVEESLNN---VEIVRSLYTKWCS 161 +L R I+ T + + K+L EES + +E V++ T++ + Sbjct: 265 EDLFERIITKKITRKQAKFFFNKWLQFEESEGDEKTIEYVKAKATEYVA 313 Score = 36.6 bits (83), Expect = 0.038, Method: Compositional matrix adjust. Identities = 42/188 (22%), Positives = 78/188 (41%), Gaps = 14/188 (7%) Query: 68 WIRYAQFEIEQHDMRRARSIFERALLV-----DSSFIPLWIRYIDAELKVKCINHARNLM 122 W+ Y F+++ ++ +AR + ERAL ++ + +WI ++ E + Sbjct: 71 WMNYMAFQLQLSEIEKARELAERALKTINFREEAEKLNIWIAMLNLENTFGTEETLEEVF 130 Query: 123 NRAISTLPRV---DKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQ 179 +RA + KL Y I E+ E+ ++ K+ V+ W S+ DF I Sbjct: 131 SRACQYMDSYTIHTKLLGIYEISEKFDKAAELFKATAKKFGG--EKVSIWVSWGDFLISH 188 Query: 180 KNWNGVREIYSKYVMAHPQ---MQTWLKWVRFENRHGNTEFTRSVY-SLAIDTVANLQNL 235 R I + A P+ ++ K+ + E G+ E RS++ L D + Sbjct: 189 NEEQEARTILGNALKALPKRNHIEVVRKFAQLEFAKGDPERGRSLFEGLVADAPKRIDLW 248 Query: 236 QIWSDMEV 243 ++ D EV Sbjct: 249 NVYVDQEV 256 >6G90-D nrPDB Length = 629 Score = 44.7 bits (104), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 35/143 (24%), Positives = 62/143 (43%), Gaps = 29/143 (20%) Query: 58 LKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINH 117 L++ L G W R+A E + ++++ ++ ++ + + LW Y L V C+N+ Sbjct: 81 LRKYPLLFGFWKRFATIEYQLFGLKKSIAVLATSVKWFPTSLELWCDY----LNVLCVNN 136 Query: 118 ARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEI 177 + NN EI + L K P W+ F++FE+ Sbjct: 137 PNE---------------------TDFIRNNFEIAKDLIGKQFLSHP---FWDKFIEFEV 172 Query: 178 RQKNWNGVREIYSKYVMAHPQMQ 200 QKNW+ V+ IY +Y++ P Q Sbjct: 173 GQKNWHNVQRIY-EYIIEVPLHQ 194 >6AHD-N nrPDB Length = 941 Score = 44.7 bits (104), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 27/104 (25%), Positives = 48/104 (46%) Query: 40 LEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFI 99 +EE +E + R Y LK+ W+ ++ E + + RAR+I E++ L + Sbjct: 718 IEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNP 777 Query: 100 PLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVE 143 LW+ + E + N A LM +A+ P LW + + +E Sbjct: 778 GLWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLE 821 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 88/467 (18%), Positives = 177/467 (37%), Gaps = 79/467 (16%) Query: 69 IRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAIST 128 +R + +E + AR + RA+ + + LW+ A +++ +AR ++N+A Sbjct: 404 VRLWKAAVELEEPEDARIMLSRAVECCPTSVELWL----ALARLETYENARKVLNKAREN 459 Query: 129 LPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNW------ 182 +P +W +EE+ N ++V + + + + + EI ++ W Sbjct: 460 IPTDRHIWITAAKLEEANGNTQMVEKIIDR------AITSLRAN-GVEINREQWIQDAEE 512 Query: 183 -----------NGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVAN 231 +R + + + TW++ H E R++Y+ A+ + Sbjct: 513 CDRAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECARAIYAYALQVFPS 572 Query: 232 LQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQF 291 +++ + + A++E E AL Q A+ P ++L L+ + ++ Sbjct: 573 KKSVWLRA-----------AYFEKNHGTRESLEALLQRAVAHCPKAEVL--WLMGAKSKW 619 Query: 292 --GDINSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKA---I 346 GD+ + ++ N + W + L SE+ +E+A + Sbjct: 620 LAGDVPAARSILAL--------AFQANPNSEEIWLAAVKLESEN------DEYERARRLL 665 Query: 347 VDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHF-TFSK 405 +R + V K W++ + L EE L +H+ F K Sbjct: 666 AKARSSAPTARVFMKSVKLEWVQD----NIRAAQDLCEEAL-----------RHYEDFPK 710 Query: 406 IWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIE-LEVKLKEFDRVRKIYEKFI 464 +W+M + + + + KAR+ + + CP + + LE K+ + R R I EK Sbjct: 711 LWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSR 770 Query: 465 EFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDE--NSDFLTKEA 509 P + +W + LE G + + AL E NS L EA Sbjct: 771 LKNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEA 817 Score = 37.7 bits (86), Expect = 0.019, Method: Compositional matrix adjust. Identities = 46/172 (26%), Positives = 79/172 (45%), Gaps = 25/172 (14%) Query: 385 EELFQRLIDDIIPHKHFTFSKI-WLMYAKFLIRHDDVPKARKILGKAIGLCPKA-KTFKG 442 E L QR + H +++ WLM AK DVP AR IL A P + + + Sbjct: 594 EALLQRAV------AHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLA 647 Query: 443 YIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDW--DRVRGIYTI---A 497 ++LE + E++R R++ K P+ +++ + +LE W D +R + A Sbjct: 648 AVKLESENDEYERARRLLAKARSSAPT-ARVFMKSVKLE-----WVQDNIRAAQDLCEEA 701 Query: 498 LDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELNQYSPQSWI 549 L DF K+ +++ I E + + EKAR+ Y + L+ +S W+ Sbjct: 702 LRHYEDF----PKLWMMKGQI--EEQKEMMEKAREAYNQGLKKCPHSTPLWL 747 Score = 35.8 bits (81), Expect = 0.063, Method: Compositional matrix adjust. Identities = 31/143 (21%), Positives = 56/143 (39%), Gaps = 1/143 (0%) Query: 68 WIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAIS 127 W+ A + + + AR+I+ AL V S +W+R E L+ RA++ Sbjct: 543 WMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRAVA 602 Query: 128 TLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNA-WNSFVDFEIRQKNWNGVR 186 P+ + LW + +V RS+ P W + V E + R Sbjct: 603 HCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENDEYERAR 662 Query: 187 EIYSKYVMAHPQMQTWLKWVRFE 209 + +K + P + ++K V+ E Sbjct: 663 RLLAKARSSAPTARVFMKSVKLE 685 Score = 34.7 bits (78), Expect = 0.14, Method: Compositional matrix adjust. Identities = 32/145 (22%), Positives = 60/145 (41%), Gaps = 6/145 (4%) Query: 406 IWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIE 465 IWL K +D+ +AR++L KA P A+ F ++LE + + E+ + Sbjct: 644 IWLAAVKLESENDEYERARRLLAKARSSAPTARVFMKSVKLEWVQDNIRAAQDLCEEALR 703 Query: 466 FQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQ 525 ++W G++EE ++ R Y L + + LL + E + Sbjct: 704 HYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKK----CPHSTPLWLLLSRL--EEKIG 757 Query: 526 EFEKARKLYRRYLELNQYSPQSWIE 550 + +AR + + N +P W+E Sbjct: 758 QLTRARAILEKSRLKNPKNPGLWLE 782 Score = 33.1 bits (74), Expect = 0.45, Method: Compositional matrix adjust. Identities = 21/91 (23%), Positives = 39/91 (42%) Query: 68 WIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAIS 127 W+ Q E ++ M +AR + + L PLW+ E K+ + AR ++ ++ Sbjct: 712 WMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRL 771 Query: 128 TLPRVDKLWYKYLIVEESLNNVEIVRSLYTK 158 P+ LW + + +E I +L K Sbjct: 772 KNPKNPGLWLESVRLEYRAGLKNIANTLMAK 802 Score = 31.2 bits (69), Expect = 1.8, Method: Compositional matrix adjust. Identities = 25/121 (20%), Positives = 47/121 (38%) Query: 68 WIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAIS 127 W+R A FE ++ +RA+ LW+ ++ + AR+++ A Sbjct: 577 WLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQ 636 Query: 128 TLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNGVRE 187 P +++W + +E + E R L K S P + V E Q N ++ Sbjct: 637 ANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAPTARVFMKSVKLEWVQDNIRAAQD 696 Query: 188 I 188 + Sbjct: 697 L 697 Score = 30.4 bits (67), Expect = 2.4, Method: Compositional matrix adjust. Identities = 21/91 (23%), Positives = 40/91 (43%) Query: 68 WIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAIS 127 +++ + E Q ++R A+ + E AL F LW+ E + + + AR N+ + Sbjct: 678 FMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLK 737 Query: 128 TLPRVDKLWYKYLIVEESLNNVEIVRSLYTK 158 P LW +EE + + R++ K Sbjct: 738 KCPHSTPLWLLLSRLEEKIGQLTRARAILEK 768 >5OQL-E nrPDB Length = 414 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 38/136 (27%), Positives = 57/136 (41%), Gaps = 12/136 (8%) Query: 39 DLEELREYQRRKRTEYEGYLKRNR-LDMGQWIRYAQFEI----EQHDMRRARSIFERALL 93 D E L K T++ Y+ R LD + R A+ I R IFERA+L Sbjct: 42 DFEHLVLAPGTKPTDFLNYVNWERSLDRLRAKRCARLNIRSVTSHASQARTFGIFERAVL 101 Query: 94 VDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVR 153 I LW+ Y++ +VK R +M RA+ P LW L + N ++ R Sbjct: 102 KHPGSIELWLAYLEFAAQVKATKRWRRIMTRALRLHPMNASLW--TLAGRRAAQNGDMQR 159 Query: 154 SLY-----TKWCSLEP 164 + ++C+ EP Sbjct: 160 ARAHFLRGCRFCTREP 175 Score = 32.3 bits (72), Expect = 0.68, Method: Compositional matrix adjust. Identities = 17/72 (23%), Positives = 29/72 (40%), Gaps = 4/72 (5%) Query: 442 GYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDEN 501 Y+E ++K R R+I + + P + +W+ G GD R R + Sbjct: 112 AYLEFAAQVKATKRWRRIMTRALRLHPMNASLWTLAGRRAAQNGDMQRARAHFL----RG 167 Query: 502 SDFLTKEAKIVL 513 F T+E + L Sbjct: 168 CRFCTREPTLWL 179 >5IC8-A nrPDB Length = 334 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 26/87 (29%), Positives = 40/87 (45%), Gaps = 7/87 (8%) Query: 83 RARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIV 142 R IFERA+L I LW+ Y++ +VK R +M RA+ P LW L Sbjct: 11 RTFGIFERAVLKHPGSIELWLAYLEFAAQVKATKRWRRIMTRALRLHPMNASLW--TLAG 68 Query: 143 EESLNNVEIVRSLY-----TKWCSLEP 164 + N ++ R+ ++C+ EP Sbjct: 69 RRAAQNGDMQRARAHFLRGCRFCTREP 95 Score = 32.3 bits (72), Expect = 0.72, Method: Compositional matrix adjust. Identities = 16/70 (22%), Positives = 28/70 (40%), Gaps = 4/70 (5%) Query: 442 GYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDEN 501 Y+E ++K R R+I + + P + +W+ G GD R R + Sbjct: 32 AYLEFAAQVKATKRWRRIMTRALRLHPMNASLWTLAGRRAAQNGDMQRARAHFL----RG 87 Query: 502 SDFLTKEAKI 511 F T+E + Sbjct: 88 CRFCTREPTL 97 >6B85-J nrPDB Length = 223 Score = 38.5 bits (88), Expect = 0.011, Method: Compositional matrix adjust. Identities = 18/51 (35%), Positives = 27/51 (52%) Query: 449 KLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALD 499 KLK D + Y+K IE +P+D W + G++ E LG D Y A++ Sbjct: 127 KLKRLDEAAEAYKKAIELKPNDASAWKELGKVLEKLGRLDEAAEAYKKAIE 177 >6G70-A nrPDB Length = 670 Score = 37.0 bits (84), Expect = 0.026, Method: Compositional matrix adjust. Identities = 65/270 (24%), Positives = 105/270 (38%), Gaps = 58/270 (21%) Query: 45 EYQRRKRTEYEGYLKR--------NRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDS 96 E++ KR +E +KR + + W Y +FEIE R +FER ++ + Sbjct: 328 EHEVSKRWTFEEGIKRPYFHVKPLEKAQLKNWKEYLEFEIENGTHERVVVLFERCVISCA 387 Query: 97 SFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLY 156 + WI+Y A+ + N +I E VR ++ Sbjct: 388 LYEEFWIKY------------AKYMENHSI-----------------------EGVRHVF 412 Query: 157 TKWCS--LEPGVNAWNSFVDFEIRQKNWNGVREI---YSKYVMAHPQMQTWLKWVRFENR 211 ++ C+ L A + FE +Q N N R I + + V+ ++ L+ V E R Sbjct: 413 SRACTVHLPKKPMAHMLWAAFEEQQGNINEARIILRTFEECVLGLAMVR--LRRVSLERR 470 Query: 212 HGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAI 271 HGN E + AI A N + +++A+ H Q+ +S + AI Sbjct: 471 HGNMEEAEHLLQDAIKN-AKSNNESSFYAIKLAR------HLFKIQKNLPKSRKVLLEAI 523 Query: 272 EKWPSNQLLKAGLLDFEKQFGDINSIEETI 301 EK N L LL+ E D+ EE I Sbjct: 524 EKDKENTKLYLNLLEMEYSC-DLKQNEENI 552 Score = 36.2 bits (82), Expect = 0.043, Method: Compositional matrix adjust. Identities = 73/387 (18%), Positives = 139/387 (35%), Gaps = 74/387 (19%) Query: 58 LKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINH 117 ++ N D W+ Q+ +++ + AR F++ + W +Y D E + I Sbjct: 91 VEMNPQDFTGWVYLLQYVEQENHLMAARKAFDKFFVHYPYCYGYWKKYADLEKRHDNIKQ 150 Query: 118 ARNLMNRAISTLPRVDKLWYKYL-IVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFE 176 + + R + +P LW Y+ ++E+L +PG N+ Sbjct: 151 SDEVYRRGLQAIPLSVDLWIHYINFLKETL----------------DPGDQETNT----- 189 Query: 177 IRQKNWNGVREIYSKYVMAHP----QMQTWLKWVRFENRHGNTEFTRSVYS--LAIDTVA 230 +R + V+A + W ++ +EN GN +VY L I T Sbjct: 190 -------TIRGTFEHAVLAAGTDFRSDKLWEMYINWENEQGNLREVTAVYDRILGIPTQL 242 Query: 231 NLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQ 290 + Q + + L E Q +++ + + P L +G+ D Sbjct: 243 YSHHFQRFKEHVQNNLPRDLLTGEQFIQLRRELASVNGHSGDDGPPGDDLPSGIEDITDP 302 Query: 291 FGDINSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAI---- 346 I IE + ++ ++ + + N ++ W TFE+ I Sbjct: 303 AKLITEIE-NMRHRIIEIHQEMFNYNEHEVSKRW----------------TFEEGIKRPY 345 Query: 347 VDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEE--LFQRLIDDIIPHKHFTFS 404 +P E ++ WK Y+ E E+EN E LF+R + ++ F Sbjct: 346 FHVKPLEKAQLKNWKEYL----------EFEIENGTHERVVVLFERCVISCALYEEF--- 392 Query: 405 KIWLMYAKFLIRHDDVPKARKILGKAI 431 W+ YAK++ H + R + +A Sbjct: 393 --WIKYAKYMENH-SIEGVRHVFSRAC 416 Score = 30.0 bits (66), Expect = 3.7, Method: Compositional matrix adjust. Identities = 32/142 (22%), Positives = 62/142 (43%), Gaps = 12/142 (8%) Query: 407 WLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTF-KGYIELEVKLKEFDRVRKIYEKFIE 465 W+ +++ + + + ARK K P + K Y +LE + + ++Y + ++ Sbjct: 101 WVYLLQYVEQENHLMAARKAFDKFFVHYPYCYGYWKKYADLEKRHDNIKQSDEVYRRGLQ 160 Query: 466 FQPSDLQIWSQY-GELEENLGDWDR-----VRGIYTIA-LDENSDFLTKEAKIVLLQKYI 518 P + +W Y L+E L D+ +RG + A L +DF + + L + YI Sbjct: 161 AIPLSVDLWIHYINFLKETLDPGDQETNTTIRGTFEHAVLAAGTDFRSDK----LWEMYI 216 Query: 519 TFETESQEFEKARKLYRRYLEL 540 +E E + +Y R L + Sbjct: 217 NWENEQGNLREVTAVYDRILGI 238 >3JCM-G nrPDB Length = 899 Score = 36.2 bits (82), Expect = 0.047, Method: Compositional matrix adjust. Identities = 26/106 (24%), Positives = 52/106 (49%), Gaps = 4/106 (3%) Query: 55 EGYLKRNRLDMGQ---WIRYAQF-EIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAEL 110 E YL RL W+ ++ EI+ + RARSI +R LL + + +I I E+ Sbjct: 689 ETYLSGTRLVPNCPLLWVSLSKIDEIDLKNPVRARSILDRGLLKNPDDVLFYIAKIQMEI 748 Query: 111 KVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLY 156 ++ ++ A L+ +A+ P LW + + + + N + ++++ Sbjct: 749 RLGNLDQAELLVTQALQKFPSNALLWVEQIKLFKHGNKSSLKKTIF 794 Score = 29.6 bits (65), Expect = 4.0, Method: Compositional matrix adjust. Identities = 25/107 (23%), Positives = 47/107 (43%), Gaps = 3/107 (2%) Query: 48 RRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYID 107 ++ RT + Y K + + WI A+ E + A+ I E +W+ I Sbjct: 224 QKMRTILKSYRKADPTNPQGWIASARLEEKARKFSVAKKIIENGCQECPRSSDIWLENI- 282 Query: 108 AELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEE-SLNNVEIVR 153 L +++ + L+ AI+ P LW+K + +E ++N +VR Sbjct: 283 -RLHESDVHYCKTLVATAINFNPTSPLLWFKAIDLESTTVNKYRVVR 328 >5WLC-LP nrPDB Length = 440 Score = 33.5 bits (75), Expect = 0.33, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 34/72 (47%), Gaps = 6/72 (8%) Query: 54 YEGYLKRNRLDMGQWIRYAQFEIEQH-DMRRARSIFERALLVDSSFIPLWIRYIDAELKV 112 Y LK + ++ WI A++E E H + + R+IF+ L + LW Y+ EL Sbjct: 133 YNQLLKLHPTNVDIWISCAKYEYEVHANFKSCRNIFQNGLRFNPDVPKLWYEYVKFEL-- 190 Query: 113 KCINHARNLMNR 124 N L+NR Sbjct: 191 ---NFITKLINR 199 Score = 33.1 bits (74), Expect = 0.43, Method: Compositional matrix adjust. Identities = 37/168 (22%), Positives = 73/168 (43%), Gaps = 19/168 (11%) Query: 49 RKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLV-DSSFIPLWIRYID 107 +KRT++E L + +I+Y +E + +R R +R L V ++ + W Sbjct: 34 KKRTDFEHRLNSRGSSINDYIKYINYESNVNKLRAKRC--KRILQVKKTNSLSDW----S 87 Query: 108 AELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNN---VEIVRSLYTKWCSLEP 164 + ++ I R + P+ K W YL ++ N + + ++Y + L P Sbjct: 88 IQQRIGFI------YQRGTNKFPQDLKFWAMYLNYMKARGNQTSYKKIHNIYNQLLKLHP 141 Query: 165 -GVNAWNSFVDFEIR-QKNWNGVREIYSKYVMAHPQM-QTWLKWVRFE 209 V+ W S +E N+ R I+ + +P + + W ++V+FE Sbjct: 142 TNVDIWISCAKYEYEVHANFKSCRNIFQNGLRFNPDVPKLWYEYVKFE 189 >2OOE-A nrPDB Length = 530 Score = 33.1 bits (74), Expect = 0.40, Method: Compositional matrix adjust. Identities = 27/86 (31%), Positives = 39/86 (45%), Gaps = 8/86 (9%) Query: 58 LKRNRLDMGQW---IRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKC 114 L+ N D+ W IR AQ + +AR +ER + S W YI+AE+K K Sbjct: 6 LEENPYDLDAWSILIREAQ----NQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKN 61 Query: 115 INHARNLMNRAISTLPRVDKLWYKYL 140 + L R + + +D LW YL Sbjct: 62 YDKVEKLFQRCLMKVLHID-LWKCYL 86 Score = 32.3 bits (72), Expect = 0.74, Method: Compositional matrix adjust. Identities = 18/59 (30%), Positives = 33/59 (55%), Gaps = 2/59 (3%) Query: 420 VPKARKILGKAIGLCPKAKTF-KGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQY 477 + KARK + + P + F K YIE E+K K +D+V K++++ + + + +W Y Sbjct: 28 IDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCL-MKVLHIDLWKCY 85 Score = 30.0 bits (66), Expect = 3.3, Method: Compositional matrix adjust. Identities = 15/52 (28%), Positives = 26/52 (50%) Query: 447 EVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIAL 498 E + + D+ RK YE+ + PS + W Y E E ++D+V ++ L Sbjct: 22 EAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCL 73 Score = 30.0 bits (66), Expect = 3.9, Method: Compositional matrix adjust. Identities = 89/442 (20%), Positives = 163/442 (36%), Gaps = 108/442 (24%) Query: 115 INHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVD 174 I+ AR R ++ P + W Y+ E N + V L+ + ++ W ++ Sbjct: 28 IDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLMKVLHIDLWKCYLS 87 Query: 175 FEIRQKNWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVA-NLQ 233 + VRE K +M Y A+D + + Sbjct: 88 Y---------VRETKGKLPSYKEKMA-------------------QAYDFALDKIGMEIM 119 Query: 234 NLQIWSD----MEVAKLVNSFAHWE---AAQQEYERSSALYQIAIEK-WPSNQLLKAGL- 284 + QIW D ++ + V S+A + A ++ Y+R I IE+ W + G+ Sbjct: 120 SYQIWVDYINFLKGVEAVGSYAENQRITAVRRVYQRGCVNPMINIEQLWRDYNKYEEGIN 179 Query: 285 LDFEKQFGDINSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEK 344 + K+ + S + + + EYET++ LD + S P Q Sbjct: 180 IHLAKKMIEDRSRDYMNARRVAKEYETVMKG-----------LDRNAPSVPPQ------- 221 Query: 345 AIVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFS 404 + P+E + WK+YI + E N L E+ Q LI + F + Sbjct: 222 ----NTPQEAQQVDMWKKYI----------QWEKSNPLRTED--QTLITKRV---MFAYE 262 Query: 405 KIWLMYAKFLIRHDDV--------PKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRV 456 + L+ L H D+ ++ K+L + G AK F D Sbjct: 263 QCLLV----LGHHPDIWYEAAQYLEQSSKLLAEK-GDMNNAKLFS------------DEA 305 Query: 457 RKIYEKFIE-FQPSDLQIWSQYGELEENLGDWDRVRGIYTIALD-ENSDFLTKEAKIVLL 514 IYE+ I ++ ++ Y + EE+ +++V IY L E+ D +V + Sbjct: 306 ANIYERAISTLLKKNMLLYFAYADYEESRMKYEKVHSIYNRLLAIEDID-----PTLVYI 360 Query: 515 QKYITFETESQEFEKARKLYRR 536 Q Y+ F ++ + R ++++ Sbjct: 361 Q-YMKFARRAEGIKSGRMIFKK 381 >5ZWN-T nrPDB Length = 544 Score = 31.6 bits (70), Expect = 1.2, Method: Compositional matrix adjust. Identities = 40/176 (22%), Positives = 71/176 (40%), Gaps = 50/176 (28%) Query: 36 DILDLEELREYQRRKRTEYEGYLKRNRLDM------GQWIRYA----------QFEIEQH 79 DI+DL++L + T + LK+ ++D+ G +++ A + + Q+ Sbjct: 192 DIMDLKQLSQ-----LTSKDELLKKLKIDINYSGRKGPYLQDAKKKLKKITKEMYMVVQY 246 Query: 80 DMRRARSIFERAL----------LVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTL 129 + SIFE + LV S I WI+Y+D + ++ + RA+ L Sbjct: 247 QVLEIYSIFESKIYINYYTSPETLVSSDEIETWIKYLDYTITLQTDSLTHLNFQRALLPL 306 Query: 130 PRVDKLWYKY-------------------LIVEESLNNVEIVRSLYTKWCSLEPGV 166 D +W KY + ++ SL EI++ LY+ C L V Sbjct: 307 AHYDLVWIKYSKWLINSKNDLLGAKNVLLMGLKFSLKKTEIIKLLYSVICKLNEYV 362 >1T6M-A nrPDB Length = 299 Score = 31.6 bits (70), Expect = 1.3, Method: Compositional matrix adjust. Identities = 13/30 (43%), Positives = 19/30 (63%) Query: 142 VEESLNNVEIVRSLYTKWCSLEPGVNAWNS 171 ++E++NN E + LY + SL G AWNS Sbjct: 216 MDETMNNSEDLNHLYINFTSLSSGGTAWNS 245 >5BN7-A nrPDB Length = 616 Score = 31.2 bits (69), Expect = 1.7, Method: Compositional matrix adjust. Identities = 41/196 (20%), Positives = 73/196 (37%), Gaps = 30/196 (15%) Query: 140 LIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNGVREIYSKYVMAH--- 196 +++ +N E+ ++ + +PGV AW + +D Q R YS ++ H Sbjct: 37 IMLRTEHDNEEMSVPMHKQRSQPQPGVTAWRAAIDLSSGQP-----RRRYSFKLLWHDRQ 91 Query: 197 ----PQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAH 252 PQ + + R E +F V + A+ QI+ D + S Sbjct: 92 RWFTPQGFSRMPPARLE------QFAVDVPDIGPQWAADQIFYQIFPD----RFARSLPR 141 Query: 253 WEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETI 312 Y +A +I + W +AG F GD++ I E + Y +K+ + Sbjct: 142 EAEQDHVYYHHAAGQEIILRDWDEPVTAQAGGSTFYG--GDLDGISEKLPYLKKLGVTAL 199 Query: 313 LSN------NAYDYDT 322 N + + YDT Sbjct: 200 YLNPVFKAPSVHKYDT 215 >4YUS-A nrPDB Length = 382 Score = 30.4 bits (67), Expect = 2.5, Method: Compositional matrix adjust. Identities = 20/64 (31%), Positives = 38/64 (59%), Gaps = 6/64 (9%) Query: 452 EFDRVRKIYEKFI-EFQPSDLQIWSQYGELEENL-GDWDRVRGIYTIALDENSDFLTKEA 509 E +++ +IYE+ + + + +D+ E++E + DW + TI LDEN+DFL + Sbjct: 69 EAEKIDRIYERILADERHTDILCLKSEVEVQERMFPDWS----MQTINLDENTDFLIRPI 124 Query: 510 KIVL 513 K++L Sbjct: 125 KVLL 128 >5A01-A nrPDB Length = 710 Score = 30.4 bits (67), Expect = 2.8, Method: Compositional matrix adjust. Identities = 22/93 (23%), Positives = 37/93 (39%), Gaps = 6/93 (6%) Query: 460 YEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYIT 519 Y++ I QP+ +S G + L D YT A+ N F + + + K Sbjct: 64 YKEAIRIQPTFADAYSNMGNTLKELQDVSGALQCYTRAIQINPAFADAHSNLASIHK--- 120 Query: 520 FETESQEFEKARKLYRRYLELNQYSPQSWIEFA 552 +S +A + YR L+L P ++ A Sbjct: 121 ---DSGNIPEAIQSYRTALKLKPDFPDAYCNLA 150 >2OND-A nrPDB Length = 308 Score = 29.6 bits (65), Expect = 4.7, Method: Compositional matrix adjust. Identities = 24/80 (30%), Positives = 40/80 (50%), Gaps = 5/80 (6%) Query: 116 NHARNLMNRAISTLPRVDKL-WYKYLIVEESLNNVEIVRSLYTKWCSLE---PGVNAWNS 171 + A N+ RAISTL + + L ++ Y EES E V S+Y + ++E P + + Sbjct: 81 DEAANIYERAISTLLKKNMLLYFAYADYEESRMKYEKVHSIYNRLLAIEDIDPTL-VYIQ 139 Query: 172 FVDFEIRQKNWNGVREIYSK 191 ++ F R + R I+ K Sbjct: 140 YMKFARRAEGIKSGRMIFKK 159 >1AUO-A nrPDB Length = 218 Score = 29.3 bits (64), Expect = 6.2, Method: Composition-based stats. Identities = 25/105 (23%), Positives = 47/105 (44%), Gaps = 11/105 (10%) Query: 543 YSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEE----- 597 Y SW + + +P L+ ++ ++ V + IE + ++A ++F Sbjct: 62 YEMPSWYDI---KAMSPARSISLEELEVSAKMVTDLIEAQ--KRTGIDASRIFLAGFSQG 116 Query: 598 -AIVFFKEKDDKQGRLSILEALKDYEETYGTELDQETVKKRFPKV 641 A+VF + QG L + AL Y T+G EL+ ++R P + Sbjct: 117 GAVVFHTAFINWQGPLGGVIALSTYAPTFGDELELSASQQRIPAL 161 >4HOQ-A nrPDB Length = 482 Score = 28.9 bits (63), Expect = 7.9, Method: Compositional matrix adjust. Identities = 24/105 (22%), Positives = 42/105 (40%), Gaps = 13/105 (12%) Query: 407 WLMYAKFLIRHDDVPKARKILGKAIGLC-------------PKAKTFKGYIELEVKLKEF 453 W YA D + +A+K GK +C P+ KG+ L+ K + Sbjct: 97 WGNYAWVYYHMDQLEEAQKYTGKIGNVCKKLSSPSNYKLECPETDCEKGWALLKFGGKYY 156 Query: 454 DRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIAL 498 + + +EK +E +P + + Y L D DR + + +L Sbjct: 157 QKAKAAFEKALEVEPDNPEFNIGYAITVYRLDDSDREGSVKSFSL 201 >4AEZ-C nrPDB Length = 223 Score = 28.5 bits (62), Expect = 8.9, Method: Compositional matrix adjust. Identities = 42/181 (23%), Positives = 76/181 (41%), Gaps = 36/181 (19%) Query: 299 ETISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAIVDSR-PKELSKN 357 E + ++RK+E L + W Y+ ++FP+ +T + R +E +N Sbjct: 54 ERMGHERKIETSESLDD---PLQVWIDYIKWTLDNFPQGETKTSGLVTLLERCTREFVRN 110 Query: 358 VQWK---RYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFL 414 +K RY+ +WM+Y+ Y++ + ELF L I + F + YA + Sbjct: 111 PLYKDDVRYLRIWMQYVNYIDEPV-------ELFSFLAHHHIGQESSIF---YEEYANYF 160 Query: 415 IRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKF----IEFQPSD 470 ++R + KA + K K +K K F R ++ Y++F +EF P Sbjct: 161 -------ESRGLFQKADEVYQKGK--------RMKAKPFLRFQQKYQQFTHRWLEFAPQS 205 Query: 471 L 471 Sbjct: 206 F 206 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5LJ5-S nrPDB 841 0.0 5XJC-J nrPDB 666 0.0 5GMK-d nrPDB 336 2e-92 6ICZ-I nrPDB 318 6e-87 6AHD-N nrPDB 304 7e-83 3JB9-R nrPDB 256 3e-68 5C9S-B nrPDB 172 6e-43 5NLG-A nrPDB 159 5e-39 5OQL-E nrPDB 116 3e-26 6G90-D nrPDB 115 8e-26 5JPZ-A nrPDB 108 7e-24 5CTQ-A nrPDB 105 6e-23 5JJW-A nrPDB 105 7e-23 5CTR-A nrPDB 100 2e-21 5JJX-A nrPDB 82 9e-16 Sequences not found previously or not previously below threshold: 6G70-A nrPDB 89 5e-18 5IC8-A nrPDB 89 6e-18 3JCM-G nrPDB 73 5e-13 2OOE-A nrPDB 70 3e-12 5MQ0-T nrPDB 60 3e-09 6B85-J nrPDB 50 3e-06 5WLC-LP nrPDB 48 1e-05 1W3B-A nrPDB 45 9e-05 4EBA-A nrPDB 41 0.001 3JB9-r nrPDB 39 0.009 5G05-C nrPDB 38 0.019 2GW1-A nrPDB 37 0.030 5UDI-A nrPDB 34 0.18 6MFV-A nrPDB 33 0.30 2OND-A nrPDB 33 0.31 5LCW-S nrPDB 33 0.34 4HOQ-A nrPDB 33 0.46 5B16-A nrPDB 32 0.67 2PLJ-A nrPDB 32 0.68 5ZYP-A nrPDB 32 0.79 4HOU-A nrPDB 32 1.1 2JGU-A nrPDB 31 1.2 3ESL-A nrPDB 30 3.0 5VU6-A nrPDB 30 3.1 6JEB-A nrPDB 30 3.8 1F7U-A nrPDB 29 7.2 6GAZ-AO nrPDB 29 8.7 5O2N-A nrPDB 28 9.8 >5LJ5-S nrPDB Length = 687 Score = 841 bits (2173), Expect = 0.0, Method: Composition-based stats. Identities = 687/687 (100%), Positives = 687/687 (100%) Query: 1 MDTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKR 60 MDTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKR Sbjct: 1 MDTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKR 60 Query: 61 NRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARN 120 NRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARN Sbjct: 61 NRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARN 120 Query: 121 LMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQK 180 LMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQK Sbjct: 121 LMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQK 180 Query: 181 NWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSD 240 NWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSD Sbjct: 181 NWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSD 240 Query: 241 MEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEET 300 MEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEET Sbjct: 241 MEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEET 300 Query: 301 ISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAIVDSRPKELSKNVQW 360 ISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAIVDSRPKELSKNVQW Sbjct: 301 ISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAIVDSRPKELSKNVQW 360 Query: 361 KRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDV 420 KRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDV Sbjct: 361 KRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDV 420 Query: 421 PKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGEL 480 PKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGEL Sbjct: 421 PKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGEL 480 Query: 481 EENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLEL 540 EENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLEL Sbjct: 481 EENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLEL 540 Query: 541 NQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEEAIV 600 NQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEEAIV Sbjct: 541 NQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEEAIV 600 Query: 601 FFKEKDDKQGRLSILEALKDYEETYGTELDQETVKKRFPKVIKKVRLQNGVEEEFVDYIF 660 FFKEKDDKQGRLSILEALKDYEETYGTELDQETVKKRFPKVIKKVRLQNGVEEEFVDYIF Sbjct: 601 FFKEKDDKQGRLSILEALKDYEETYGTELDQETVKKRFPKVIKKVRLQNGVEEEFVDYIF 660 Query: 661 PDDIDDDKPKPSKFLELAKKWKQEQAL 687 PDDIDDDKPKPSKFLELAKKWKQEQAL Sbjct: 661 PDDIDDDKPKPSKFLELAKKWKQEQAL 687 >5XJC-J nrPDB Length = 848 Score = 666 bits (1718), Expect = 0.0, Method: Composition-based stats. Identities = 260/691 (37%), Positives = 409/691 (59%), Gaps = 56/691 (8%) Query: 7 TAVDTHVSAEQILRDVYKKG-QKARGSTNIDILDLEELREYQRRKRTEYEGYLKRNRLDM 65 + ++AEQ+LR+ ++ + I D EEL +Y+ RKR +E +++NR + Sbjct: 183 APAEVQITAEQLLREAKERELELLPPPPQQKITDEEELNDYKLRKRKTFEDNIRKNRTVI 242 Query: 66 GQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRA 125 WI+YAQ+E +++RARSI+ERAL VD I LW++Y + E+K + +NHARN+ +RA Sbjct: 243 SNWIKYAQWEESLKEIQRARSIYERALDVDYRNITLWLKYAEMEMKNRQVNHARNIWDRA 302 Query: 126 ISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNGV 185 I+TLPRV++ WYKY +EE L NV R ++ +W +P AW+S+++FE+R K + Sbjct: 303 ITTLPRVNQFWYKYTYMEEMLGNVAGARQVFERWMEWQPEEQAWHSYINFELRYKEVDRA 362 Query: 186 REIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAK 245 R IY ++V+ HP ++ W+K+ RFE +H R VY A++ + + Sbjct: 363 RTIYERFVLVHPDVKNWIKYARFEEKHAYFAHARKVYERAVEFFGD--------EHMDEH 414 Query: 246 LVNSFAHWEAAQQEYERSSALYQIA---IEKWPSNQLLKAGLLDFEKQFGDINSIEETIS 302 L +FA +E Q+E+ER +Y+ A I K + +L K + FEK+FGD IE+ I Sbjct: 415 LYVAFAKFEENQKEFERVRVIYKYALDRISKQDAQELFKNYTI-FEKKFGDRRGIEDIIV 473 Query: 303 YKRKMEYETILSNNAYDYDTWWLYLDL-ISESFPKQIMQTFEKAIVDSRPKELSKNVQWK 361 KR+ +YE + N ++YD W+ YL L S++ + + + +E+AI + P + + WK Sbjct: 474 SKRRFQYEEEVKANPHNYDAWFDYLRLVESDAEAEAVREVYERAIANVPP--IQEKRHWK 531 Query: 362 RYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVP 421 RYIYLW+ Y Y ELE ++ +++Q + ++IPHK FTF+K+W++YA+F IR ++ Sbjct: 532 RYIYLWINYALYEELEAKDPERTRQVYQASL-ELIPHKKFTFAKMWILYAQFEIRQKNLS 590 Query: 422 KARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELE 481 AR+ LG +IG CPK K FK YIELE++L+EFDR RK+YEKF+EF P + W ++ ELE Sbjct: 591 LARRALGTSIGKCPKNKLFKVYIELELQLREFDRCRKLYEKFLEFGPENCTSWIKFAELE 650 Query: 482 ENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELN 541 LGD DR R IY +A+ + + + VL + YI FE E +E E+ R LYRR L+ Sbjct: 651 TILGDIDRARAIYELAISQPRLDMPE----VLWKSYIDFEIEQEETERTRNLYRRLLQRT 706 Query: 542 QYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEEAIVF 601 Q+ + WI FA ++ S+ E L + R+++EEA Sbjct: 707 QHV-KVWISFAQFELSSGKEGSL------------------------TKCRQIYEEANKT 741 Query: 602 FKEKDDKQGRLSILEALKDYEETYGTELDQETVKKRFPKVIK---KVRLQNGVE---EEF 655 + ++K+ RL +LE+ + +EE +GT D+E V K P+ +K KV+ +G + EE+ Sbjct: 742 MRNCEEKEERLMLLESWRSFEEEFGTASDKERVDKLMPEKVKKRRKVQTDDGSDAGWEEY 801 Query: 656 VDYIFPDDIDDDKPKPS-KFLELAKKWKQEQ 685 DYIFP+D + +P+ K L +AK WK++Q Sbjct: 802 FDYIFPEDAAN---QPNLKLLAMAKLWKKQQ 829 Score = 97.3 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 65/337 (19%), Positives = 140/337 (41%), Gaps = 17/337 (5%) Query: 332 ESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRL 391 + ++ + KA + + + K + ++ E L + +L +R Sbjct: 170 KQRIPKVAKVKNKAPAEVQITAEQLLREAKERELELLPPPPQQKITDEEELNDYKLRKRK 229 Query: 392 IDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLC-PKAKTFKGYIELEVKL 450 + K+ T W+ YA++ ++ +AR I +A+ + + Y E+E+K Sbjct: 230 TFEDNIRKNRTVISNWIKYAQWEESLKEIQRARSIYERALDVDYRNITLWLKYAEMEMKN 289 Query: 451 KEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAK 510 ++ + R I+++ I P Q W +Y +EE LG+ R ++ ++ E + Sbjct: 290 RQVNHARNIWDRAITTLPRVNQFWYKYTYMEEMLGNVAGARQVFERWME-----WQPEEQ 344 Query: 511 IVLLQKYITFETESQEFEKARKLYRRYLELNQYSPQSWIEFAMYQT---STPTEQQLLDL 567 YI FE +E ++AR +Y R++ L ++WI++A ++ +++ + Sbjct: 345 A--WHSYINFELRYKEVDRARTIYERFV-LVHPDVKNWIKYARFEEKHAYFAHARKVYER 401 Query: 568 AKLQSENVDEDIEFEITDENKLEARKVFEEAIVFFK---EKDDKQGRLSILEALKDYEET 624 A + D + E +K FE V +K ++ KQ + + +E+ Sbjct: 402 AVEFFGDEHMDEHLYVAFAKFEENQKEFERVRVIYKYALDRISKQDAQELFKNYTIFEKK 461 Query: 625 YGTELDQET--VKKRFPKVIKKVRLQNGVEEEFVDYI 659 +G E V KR + ++V+ + + DY+ Sbjct: 462 FGDRRGIEDIIVSKRRFQYEEEVKANPHNYDAWFDYL 498 >5GMK-d nrPDB Length = 687 Score = 336 bits (861), Expect = 2e-92, Method: Composition-based stats. Identities = 275/275 (100%), Positives = 275/275 (100%) Query: 1 MDTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKR 60 MDTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKR Sbjct: 1 MDTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKR 60 Query: 61 NRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARN 120 NRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARN Sbjct: 61 NRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARN 120 Query: 121 LMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQK 180 LMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQK Sbjct: 121 LMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQK 180 Query: 181 NWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSD 240 NWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSD Sbjct: 181 NWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSD 240 Query: 241 MEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWP 275 MEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWP Sbjct: 241 MEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWP 275 Score = 215 bits (546), Expect = 6e-56, Method: Composition-based stats. Identities = 63/255 (24%), Positives = 112/255 (43%), Gaps = 26/255 (10%) Query: 293 DINSIEETISYKRK--MEYETILSNNAYDYDTWWLYLDL-ISESFPKQIMQTFEKAIVDS 349 DI +EE Y+R+ EYE L N D W Y I + ++ FE+A++ Sbjct: 36 DILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVD 95 Query: 350 RPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLM 409 +I LW+RYI EL+++ L R I +P K+W Sbjct: 96 S-----------SFIPLWIRYID-AELKVKCINHARNLMNRAIS-TLPR----VDKLWYK 138 Query: 410 YAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPS 469 Y ++V R + K L P + +++ E++ K ++ VR+IY K++ P Sbjct: 139 YLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNGVREIYSKYVMAHPQ 198 Query: 470 DLQIWSQYGELEENLGDWDRVRGIYTIALD-----ENSDFLTKEAKIVLLQKYITFETES 524 +Q W ++ E G+ + R +Y++A+D +N + L+ + +E Sbjct: 199 -MQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQ 257 Query: 525 QEFEKARKLYRRYLE 539 QE+E++ LY+ +E Sbjct: 258 QEYERSSALYQIAIE 272 Score = 84.2 bits (206), Expect = 2e-16, Method: Composition-based stats. Identities = 35/154 (22%), Positives = 73/154 (47%), Gaps = 9/154 (5%) Query: 407 WLMYAKFLIRHDDVPKARKILGKAIGLCPK-AKTFKGYIELEVKLKEFDRVRKIYEKFIE 465 W+ YA+F I D+ +AR I +A+ + + YI+ E+K+K + R + + I Sbjct: 68 WIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAIS 127 Query: 466 FQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQ 525 P ++W +Y +EE+L + + VR +YT E + ++ FE + Sbjct: 128 TLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSL-------EPGVNAWNSFVDFEIRQK 180 Query: 526 EFEKARKLYRRYLELNQYSPQSWIEFAMYQTSTP 559 + R++Y +Y+ + Q+W+++ ++ Sbjct: 181 NWNGVREIYSKYV-MAHPQMQTWLKWVRFENRHG 213 Score = 53.8 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 36/184 (19%), Positives = 68/184 (36%), Gaps = 14/184 (7%) Query: 420 VPKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGE 479 R + K ++LE + R R YE +++ D+ W +Y + Sbjct: 16 EQILRDVYKKGQKARGSTNI--DILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQ 73 Query: 480 LEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLE 539 E D R R I+ AL L + I L +YI E + + AR L R + Sbjct: 74 FEIEQHDMRRARSIFERAL------LVDSSFIPLWIRYIDAELKVKCINHARNLMNRAIS 127 Query: 540 LNQYSPQSWIEFAMYQTSTPTEQQLLDL------AKLQSENVDEDIEFEITDENKLEARK 593 + W ++ + + S + + L + + ++FEI +N R+ Sbjct: 128 TLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNGVRE 187 Query: 594 VFEE 597 ++ + Sbjct: 188 IYSK 191 >6ICZ-I nrPDB Length = 855 Score = 318 bits (813), Expect = 6e-87, Method: Composition-based stats. Identities = 104/499 (20%), Positives = 203/499 (40%), Gaps = 88/499 (17%) Query: 67 QWIRYAQFEIEQHDMRRARSIFERALLV-----DSSFIPLWIRYIDAE-LKVKCINHARN 120 W+ Y QF ++Q + R F+RAL S PL++R++ + L + R Sbjct: 112 LWLDYCQFLMDQGRVTHTRRTFDRALRALPITQHSRIWPLYLRFLRSHPLPETAVRGYRR 171 Query: 121 LMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYT-----KWCSLEPGVN--AWNSFV 173 + + P + + +YL + L+ E + L T ++ S N W+ Sbjct: 172 FLKLS----PESAEEYIEYLKSSDRLD--EAAQRLATVVNDERFVSKAGKSNYQLWHELC 225 Query: 174 DF------EIRQKNWNGVREIYSKYVMAHPQM-QTWLKWVRFENRHGNTEFTRSVYSLAI 226 D +++ N + + I Q+ + W + R G+ E R VY AI Sbjct: 226 DLISQNPDKVQSLNVDAI--IRGGLTRFTDQLGKLWCSLADYYIRSGHFEKARDVYEEAI 283 Query: 227 DTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLD 286 TV +++ ++ +S+A +E + IA + +++L + D Sbjct: 284 RTVMTVRDF--------TQVFDSYAQFEESM-----------IAAKMETASELGREEEDD 324 Query: 287 FEKQFGDINSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAI 346 + + + E+ IS + + +L N + W + L + P++I+ T+ +A+ Sbjct: 325 VDLEL-RLARFEQLISRRPLLLNSVLLRQNPHHVHEWHKRVAL-HQGRPREIINTYTEAV 382 Query: 347 VDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHF----T 402 P + + LW+ + + E +N L++ R+I + +F Sbjct: 383 QTVDPFKATGKPH-----TLWVAFAKFYE---DNGQLDD---ARVILEKATKVNFKQVDD 431 Query: 403 FSKIWLMYAKFLIRHDDVPKARKILGKAIGL-CPKAKTFKGYIELEVKLKEFDRVRKIYE 461 + +W + +RH++ +A ++L KA L +A+ F G ++ +RV K Sbjct: 432 LASVWCQCGELELRHENYDEALRLLRKATALPARRAEYFDGSEPVQ------NRVYK--- 482 Query: 462 KFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFE 521 L++WS +LEE+LG + + +Y D D +IV+ Y F Sbjct: 483 --------SLKVWSMLADLEESLGTFQSTKAVY----DRILDLRIATPQIVI--NYAMFL 528 Query: 522 TESQEFEKARKLYRRYLEL 540 E + FE++ K Y R + L Sbjct: 529 EEHKYFEESFKAYERGISL 547 Score = 79.2 bits (193), Expect = 6e-15, Method: Composition-based stats. Identities = 78/438 (17%), Positives = 166/438 (37%), Gaps = 27/438 (6%) Query: 199 MQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQ 258 W+ + +F +G + R + A + + +L +++ A + Sbjct: 395 HTLWVAFAKFYEDNGQLDDARVILEKATKVNFKQVDDLASVWCQCGELELRHENYDEALR 454 Query: 259 EYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETIS--YKRKMEYETILSNN 316 +++AL E + ++ ++ + K + + +EE++ K Y+ IL Sbjct: 455 LLRKATALPARRAEYFDGSEPVQNRVYKSLKVWSMLADLEESLGTFQSTKAVYDRILDLR 514 Query: 317 AYDYDTWWLYLDLISES-FPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVE 375 Y + E + ++ + +E+ I S K + + W Y+ ++ + Sbjct: 515 IATPQIVINYAMFLEEHKYFEESFKAYERGI--SLFKWPNVSDIWSTYLTKFIARYGGRK 572 Query: 376 LELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGL-C 434 LE +LF++ +D P T ++L+YA+ A + +A Sbjct: 573 LE-----RARDLFEQALDGCPPKYAKT---LYLLYAQLEEEWGLARHAMAVYERATRAVE 624 Query: 435 PKAKT--FKGYIELEVKLKEFDRVRKIYEKFIEFQPSD--LQIWSQYGELEENLGDWDRV 490 P + F YI+ ++ R IY+K IE + ++ ++ ++E LG+ DR Sbjct: 625 PAQQYDMFNIYIKRAAEIYGVTHTRGIYQKAIEVLSDEHAREMCLRFADMECKLGEIDRA 684 Query: 491 RGIYTIALDENSDFLTKEAKIVLLQKYITFETES--QEFEKARKLYRRYLELNQYSPQSW 548 R IY+ S Q + FE ++ K RR ++ + ++ Sbjct: 685 RAIYSFC----SQICDPRTTGAFWQTWKDFEVRHGNEDTIKEMLRIRRSVQATYNTQVNF 740 Query: 549 IEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARK---VFEEAIVFFKEK 605 + M + S + DLA QS D + + ++ EA + + ++ + F Sbjct: 741 MASQMLKVSGSATGTVSDLAPGQSGMDDMKLLEQRAEQLAAEAERDQPLRAQSKILFVRS 800 Query: 606 DDKQGRLSILEALKDYEE 623 D + L+ L + EE Sbjct: 801 DASREELAELAQQVNPEE 818 Score = 73.1 bits (177), Expect = 4e-13, Method: Composition-based stats. Identities = 47/344 (13%), Positives = 111/344 (32%), Gaps = 55/344 (15%) Query: 294 INSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAIVDSRPKE 353 + + + + YE + N + W Y++ + ++ Q +E+A+ Sbjct: 9 RPERPDLVFEEEDLPYEEEIMRNQFSVKCWLRYIEFKQGAPKPRLNQLYERALKLLPCSY 68 Query: 354 LSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRL--IDDIIPHKHFTFSKIWLMYA 411 LW RY+ ++++ + + ++ + + ++WL Y Sbjct: 69 K-----------LWYRYLKARRAQVKHRCVTDPAYEDVNNCHERAFVFMHKMPRLWLDYC 117 Query: 412 KFLIRHDDVPKARKILGKAIGLCP---KAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQP 468 +FL+ V R+ +A+ P ++ + Y+ + + Y +F++ P Sbjct: 118 QFLMDQGRVTHTRRTFDRALRALPITQHSRIWPLYLRFLRSHPLPETAVRGYRRFLKLSP 177 Query: 469 SDLQIWSQYG--------------------ELEENLG----------------DWDRVRG 492 + + +Y G + D+V+ Sbjct: 178 ESAEEYIEYLKSSDRLDEAAQRLATVVNDERFVSKAGKSNYQLWHELCDLISQNPDKVQS 237 Query: 493 IYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELNQYS---PQSWI 549 + A+ + L + S FEKAR +Y + Q + Sbjct: 238 LNVDAIIRGGLTRFTDQLGKLWCSLADYYIRSGHFEKARDVYEEAIRTVMTVRDFTQVFD 297 Query: 550 EFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARK 593 +A ++ S + + E D D+E + +L +R+ Sbjct: 298 SYAQFEESMIAAKMETASELGREEEDDVDLELRLARFEQLISRR 341 >6AHD-N nrPDB Length = 941 Score = 304 bits (779), Expect = 7e-83, Method: Composition-based stats. Identities = 108/613 (17%), Positives = 216/613 (35%), Gaps = 107/613 (17%) Query: 4 LEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKRNRL 63 LE + +A+ ++ + S I I E + + +KR L+ Sbjct: 347 LEAARLQPGDTAKAVVAQAVRH---LPQSVRIYIRAAELETDIRAKKRV-LRKALEHVPN 402 Query: 64 DMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMN 123 + W + E + AR + RA+ + + LW+ E +AR ++N Sbjct: 403 SVRLWKAAVELE----EPEDARIMLSRAVECCPTSVELWLALARLE----TYENARKVLN 454 Query: 124 RAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNW- 182 +A +P +W +EE+ N ++V + + + EI ++ W Sbjct: 455 KARENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRAN-------GVEINREQWI 507 Query: 183 ----------------NGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAI 226 +R + + + TW++ H E R++Y+ A+ Sbjct: 508 QDAEECDRAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECARAIYAYAL 567 Query: 227 DTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLD 286 + +++ + + A++E E AL Q A+ P ++L L+ Sbjct: 568 QVFPSKKSVWLRA-----------AYFEKNHGTRESLEALLQRAVAHCPKAEVL--WLMG 614 Query: 287 FEKQF--GDINSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEK 344 + ++ GD+ + ++ N + W + L SE+ +E+ Sbjct: 615 AKSKWLAGDVPAARSILAL--------AFQANPNSEEIWLAAVKLESEN------DEYER 660 Query: 345 A---IVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHF 401 A + +R + V K W++ + L EE L + Sbjct: 661 ARRLLAKARSSAPTARVFMKSVKLEWVQD----NIRAAQDLCEEAL----------RHYE 706 Query: 402 TFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYI-ELEVKLKEFDRVRKIY 460 F K+W+M + + + + KAR+ + + CP + + LE K+ + R R I Sbjct: 707 DFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAIL 766 Query: 461 EKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDE--NSDFLTKEAKIV------ 512 EK P + +W + LE G + + AL E NS L EA + Sbjct: 767 EKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQR 826 Query: 513 ----------------LLQKYITFETESQEFEKARKLYRRYLELNQYSPQSWIEFAMYQT 556 +L ++ KAR+ + R ++++ +W F ++ Sbjct: 827 RTKSVDALKKCEHDPHVLLAVAKLFWSQRKITKAREWFHRTVKIDSDLGDAWAFFYKFEL 886 Query: 557 STPTEQQLLDLAK 569 TE+Q ++ K Sbjct: 887 QHGTEEQQEEVRK 899 Score = 122 bits (305), Expect = 5e-28, Method: Composition-based stats. Identities = 47/227 (20%), Positives = 82/227 (36%), Gaps = 11/227 (4%) Query: 40 LEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFI 99 +EE +E + R Y LK+ W+ ++ E + + RAR+I E++ L + Sbjct: 718 IEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNP 777 Query: 100 PLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKW 159 LW+ + E + N A LM +A+ P LW + + +E K Sbjct: 778 GLWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVDALKK- 836 Query: 160 CSLEPGVNAWNSFVDFEIRQKNWNGVREIYSKYV-MAHPQMQTWLKWVRFENRHGNTEFT 218 C +P V + Q+ RE + + V + W + +FE +HG E Sbjct: 837 CEHDPHVLL--AVAKLFWSQRKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQ 894 Query: 219 RSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSA 265 V L ++ A+W+ + R A Sbjct: 895 EEVRKRCESAEPRHGELWCAVSKDI-------ANWQKKIGDILRLVA 934 Score = 68.0 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 43/263 (16%), Positives = 90/263 (34%), Gaps = 19/263 (7%) Query: 40 LEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFI 99 LE +++ R + E L+ W+ Q E ++ M +AR + + L Sbjct: 684 LEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHST 743 Query: 100 PLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKW 159 PLW+ E K+ + AR ++ ++ P+ LW + + +E I +L K Sbjct: 744 PLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAKA 803 Query: 160 CSLEPGVNA-WNSFVDFEIRQKNWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFT 218 P W+ + E R + + + + H L + Sbjct: 804 LQECPNSGILWSEAIFLEARPQR--RTKSVDALKKCEHDPHVL-LAVAKLFWSQRKITKA 860 Query: 219 RSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQ 278 R + + ++L + + F +E E+ + + P + Sbjct: 861 REWFHRTVKIDSDLGDAWAF-----------FYKFELQHGTEEQQEEVRKRCESAEPRHG 909 Query: 279 LL----KAGLLDFEKQFGDINSI 297 L + +++K+ GDI + Sbjct: 910 ELWCAVSKDIANWQKKIGDILRL 932 Score = 56.5 bits (134), Expect = 4e-08, Method: Composition-based stats. Identities = 59/295 (20%), Positives = 102/295 (34%), Gaps = 40/295 (13%) Query: 381 SLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTF 440 + + RL+ + + W+ A+ + AR ++ K +CPK++ Sbjct: 286 GDINDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDV 345 Query: 441 KGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDE 500 +L+ D + + + + P ++I+ + ELE D + + AL+ Sbjct: 346 WLEAA---RLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELET---DIRAKKRVLRKALEH 399 Query: 501 --NSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELNQYSPQSWIEFAMYQTST 558 NS L K A E +E E AR + R +E S + W+ A +T Sbjct: 400 VPNSVRLWKAA------------VELEEPEDARIMLSRAVECCPTSVELWLALARLETYE 447 Query: 559 PTEQQLLDLAKLQSENVDEDIEFEITDENKLEA-------RKVFEEAIVFFKEKDDKQGR 611 + L EN+ D IT EA K+ + AI + + R Sbjct: 448 NARKVL----NKARENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINR 503 Query: 612 LSILEALKDYEETYGTELDQETVKKRFPKVIKKVRLQNGVEEEFVDYIFPDDIDD 666 E E T + VI G+EEE + + +D D Sbjct: 504 ----EQWIQDAEECDRAGSVATCQAVMRAVIGI-----GIEEEDRKHTWMEDADS 549 >3JB9-R nrPDB Length = 674 Score = 256 bits (652), Expect = 3e-68, Method: Composition-based stats. Identities = 114/258 (44%), Positives = 165/258 (63%), Gaps = 10/258 (3%) Query: 36 DILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVD 95 +I DLEEL+E+Q RKR E+E ++RNRL MG W+RY Q+E++Q + RARS+FERAL VD Sbjct: 41 NITDLEELQEFQGRKRKEFEDAIRRNRLAMGHWMRYGQWELDQKEFARARSVFERALDVD 100 Query: 96 SSFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSL 155 S++IPLW++YI+ E+K + INHARNL +RA++ LPRVDKLWYKY+ +EE L N+ R + Sbjct: 101 STYIPLWLKYIECEMKNRNINHARNLFDRAVTQLPRVDKLWYKYVYMEEMLGNITGCRQV 160 Query: 156 YTKWCSLEPGVNAWNSFVDFEIRQKNWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNT 215 + +W EP N W S++ E R R IY ++V+ HP++ WL+W RFE GN Sbjct: 161 FERWLKWEPDENCWMSYIRMERRYHENERARGIYERFVVVHPEVTNWLRWARFEEECGNA 220 Query: 216 EFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWP 275 R VY AID + + + +FA +E Q+EYER+ +++ AI+ P Sbjct: 221 ANVRQVYLAAIDALG--------QEFLNERFFIAFAKFEIRQKEYERARTIFKYAIDFMP 272 Query: 276 SNQLLK--AGLLDFEKQF 291 ++ ++ FEKQF Sbjct: 273 RSKSMELYKEYTHFEKQF 290 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 67/275 (24%), Positives = 118/275 (42%), Gaps = 31/275 (11%) Query: 293 DINSIEETISYKRKMEYETILSNNAYDYDTWWLY--LDLISESFPKQIMQTFEKAIVDSR 350 D+ ++E KRK E+E + N W Y +L + F + FE+A+ D Sbjct: 44 DLEELQEFQGRKRK-EFEDAIRRNRLAMGHWMRYGQWELDQKEFAR-ARSVFERAL-DVD 100 Query: 351 PKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMY 410 YI LW++YI E++ N LF R + + K+W Y Sbjct: 101 S----------TYIPLWLKYIE-CEMKNRNINHARNLFDRAVTQLP-----RVDKLWYKY 144 Query: 411 AKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSD 470 ++ R++ + + P + YI +E + E +R R IYE+F+ P Sbjct: 145 VYMEEMLGNITGCRQVFERWLKWEPDENCWMSYIRMERRYHENERARGIYERFVVVHPE- 203 Query: 471 LQIWSQYGELEENLGDWDRVRGIYTIALDE-NSDFLTKEAKIVLLQKYITFETESQEFEK 529 + W ++ EE G+ VR +Y A+D +FL + I + FE +E+E+ Sbjct: 204 VTNWLRWARFEEECGNAANVRQVYLAAIDALGQEFLNERFFIA----FAKFEIRQKEYER 259 Query: 530 ARKLYRRYLELNQYSPQSWIEFAMYQTSTPTEQQL 564 AR +++ ++ + P+S +Y+ T E+Q Sbjct: 260 ARTIFKYAID---FMPRS-KSMELYKEYTHFEKQF 290 >5C9S-B nrPDB Length = 572 Score = 172 bits (434), Expect = 6e-43, Method: Composition-based stats. Identities = 55/277 (19%), Positives = 112/277 (40%), Gaps = 22/277 (7%) Query: 88 FERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTL---PRVDKL--WYKYLIV 142 FER L+ + + +W+ Y+ +L++ I AR L RA+ T+ +KL W L + Sbjct: 307 FERLLIGNPNSSVVWMNYMAFQLQLSEIEKARELAERALKTINFREEAEKLNIWIAMLNL 366 Query: 143 EESLNNVEIVRSLYTKWCSLEPGVNAWNSFVD-FEIRQKNWNGVREIYSKYV--MAHPQM 199 E + E + ++++ C + +EI +K ++ E++ ++ Sbjct: 367 ENTFGTEETLEEVFSRACQYMDSYTIHTKLLGIYEISEK-FDKAAELFKATAKKFGGEKV 425 Query: 200 QTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQE 259 W+ W F H + R++ A+ + ++++ V FA E A+ + Sbjct: 426 SIWVSWGDFLISHNEEQEARTILGNALKALPKRNHIEV---------VRKFAQLEFAKGD 476 Query: 260 YERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAYD 319 ER +L++ + P L +D E + D +E+ ++R + + + Sbjct: 477 PERGRSLFEGLVADAPKRIDLWNVYVDQEVKAKDKKKVEDL--FERIITKKITRKQAKFF 534 Query: 320 YDTWWLYLDLISESFPKQIMQTFEKAIVDSRPKELSK 356 ++ W + + SE K I KA E K Sbjct: 535 FNKWLQFEE--SEGDEKTIEYVKAKATEYVASHESQK 569 Score = 111 bits (278), Expect = 7e-25, Method: Composition-based stats. Identities = 44/281 (15%), Positives = 97/281 (34%), Gaps = 29/281 (10%) Query: 254 EAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETIL 313 + + E A ++ + P++ ++ + F+ Q +I E K Sbjct: 295 DINTRAPESV-ADFERLLIGNPNSSVVWMNYMAFQLQLSEIEKARELAERALKTIN---F 350 Query: 314 SNNAYDYDTWWLYLDLISE-SFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYIC 372 A + W L+L + + + + F +A + + Sbjct: 351 REEAEKLNIWIAMLNLENTFGTEETLEEVFSRACQYMDSYTIHTKLLGIY---------- 400 Query: 373 YVELELENSLLEEELFQRLIDDIIPHKHFTFSK--IWLMYAKFLIRHDDVPKARKILGKA 430 + E+ + K F K IW+ + FLI H++ +AR ILG A Sbjct: 401 ---------EISEKFDKAAELFKATAKKFGGEKVSIWVSWGDFLISHNEEQEARTILGNA 451 Query: 431 IGLCP---KAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDW 487 + P + + + +LE + +R R ++E + P + +W+ Y + E D Sbjct: 452 LKALPKRNHIEVVRKFAQLEFAKGDPERGRSLFEGLVADAPKRIDLWNVYVDQEVKAKDK 511 Query: 488 DRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFE 528 +V ++ + + + ++ E + + E Sbjct: 512 KKVEDLFERIITKKITRKQAKFFFNKWLQFEESEGDEKTIE 552 Score = 46.1 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 47/258 (18%), Positives = 93/258 (36%), Gaps = 49/258 (18%) Query: 439 TFKGYIELEVKLKEFDRVRKIYEKFIE-----FQPSDLQIWSQYGELEENLGDWDRVRGI 493 + Y+ +++L E ++ R++ E+ ++ + L IW LE G + + + Sbjct: 320 VWMNYMAFQLQLSEIEKARELAERALKTINFREEAEKLNIWIAMLNLENTFGTEETLEEV 379 Query: 494 YTIA----------------------LDENSDFLTKEA------KIVLLQKYITFETESQ 525 ++ A D+ ++ A K+ + + F Sbjct: 380 FSRACQYMDSYTIHTKLLGIYEISEKFDKAAELFKATAKKFGGEKVSIWVSWGDFLISHN 439 Query: 526 EFEKARKLYRRYLEL--NQYSPQSWIEFAMYQTSTP--------TEQQLLDLAK-LQSEN 574 E ++AR + L+ + + +FA + + E + D K + N Sbjct: 440 EEQEARTILGNALKALPKRNHIEVVRKFAQLEFAKGDPERGRSLFEGLVADAPKRIDLWN 499 Query: 575 VDEDIEFEITDENKLEARKVFEEAIVFFKEKDDKQGRLSILEALKDYEETYGTELDQETV 634 V D E + D+ K+E +FE I K+ KQ + +EE+ G E E V Sbjct: 500 VYVDQEVKAKDKKKVE--DLFERIIT--KKITRKQAKF-FFNKWLQFEESEGDEKTIEYV 554 Query: 635 KKRFPKVIKKVRLQNGVE 652 K + + + Q E Sbjct: 555 KAKATEYVASHESQKADE 572 >5NLG-A nrPDB Length = 314 Score = 159 bits (401), Expect = 5e-39, Method: Composition-based stats. Identities = 42/223 (18%), Positives = 89/223 (39%), Gaps = 16/223 (7%) Query: 88 FERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTL---PRVDKL--WYKYLIV 142 FER L+ + + +W+ Y+ +L++ I AR L RA+ T+ +KL W L + Sbjct: 57 FERLLIGNPNSSVVWMNYMAFQLQLSEIEKARELAERALKTINFREEAEKLNIWIAMLNL 116 Query: 143 EESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNGVREIYSKYV--MAHPQMQ 200 E + E + ++++ C + + ++ E++ ++ Sbjct: 117 ENTFGTEETLEEVFSRACQYMDSYTIHTKLLGIYEISEKFDKAAELFKATAKKFGGEKVS 176 Query: 201 TWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEY 260 W+ W F H + R++ A+ + ++++ V FA E A+ + Sbjct: 177 IWVSWGDFLISHNEEQEARTILGNALKALPKRNHIEV---------VRKFAQLEFAKGDP 227 Query: 261 ERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETISY 303 ER +L++ + P L +D E + D +E+ Sbjct: 228 ERGRSLFEGLVADAPKRIDLWNVYVDQEVKAKDKKKVEDLFER 270 Score = 103 bits (257), Expect = 2e-22, Method: Composition-based stats. Identities = 44/281 (15%), Positives = 97/281 (34%), Gaps = 29/281 (10%) Query: 254 EAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETIL 313 + + E A ++ + P++ ++ + F+ Q +I E K Sbjct: 45 DINTRAPESV-ADFERLLIGNPNSSVVWMNYMAFQLQLSEIEKARELAERALKTIN---F 100 Query: 314 SNNAYDYDTWWLYLDLISE-SFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYIC 372 A + W L+L + + + + F +A + + Sbjct: 101 REEAEKLNIWIAMLNLENTFGTEETLEEVFSRACQYMDSYTIHTKLLGIY---------- 150 Query: 373 YVELELENSLLEEELFQRLIDDIIPHKHFTFSK--IWLMYAKFLIRHDDVPKARKILGKA 430 + E+ + K F K IW+ + FLI H++ +AR ILG A Sbjct: 151 ---------EISEKFDKAAELFKATAKKFGGEKVSIWVSWGDFLISHNEEQEARTILGNA 201 Query: 431 IGLCP---KAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDW 487 + P + + + +LE + +R R ++E + P + +W+ Y + E D Sbjct: 202 LKALPKRNHIEVVRKFAQLEFAKGDPERGRSLFEGLVADAPKRIDLWNVYVDQEVKAKDK 261 Query: 488 DRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFE 528 +V ++ + + + ++ E + + E Sbjct: 262 KKVEDLFERIITKKITRKQAKFFFNKWLQFEESEGDEKTIE 302 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 33/220 (15%), Positives = 79/220 (35%), Gaps = 29/220 (13%) Query: 439 TFKGYIELEVKLKEFDRVRKIYEKFIE-----FQPSDLQIWSQYGELEENLGDWDRVRGI 493 + Y+ +++L E ++ R++ E+ ++ + L IW LE G + + + Sbjct: 70 VWMNYMAFQLQLSEIEKARELAERALKTINFREEAEKLNIWIAMLNLENTFGTEETLEEV 129 Query: 494 YTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELNQYSPQSWIEFAM 553 ++ A + + + + F+ ++ F+ K + W+ + Sbjct: 130 FSRACQYMDSYTIHTKLLGIYEISEKFDKAAELFKATAKKF------GGEKVSIWVSWGD 183 Query: 554 YQTSTPTEQQLLDL---------AKLQSENVDEDIEFEITDENKLEARKVFEEAIVFFKE 604 + S EQ+ + + E V + + E + R +FE + Sbjct: 184 FLISHNEEQEARTILGNALKALPKRNHIEVVRKFAQLEFAKGDPERGRSLFEGLVA---- 239 Query: 605 KDDKQGRLSILEALKDYEETYGTELDQETVKKRFPKVIKK 644 D R+ + Y + D++ V+ F ++I K Sbjct: 240 --DAPKRIDL---WNVYVDQEVKAKDKKKVEDLFERIITK 274 >5OQL-E nrPDB Length = 414 Score = 116 bits (290), Expect = 3e-26, Method: Composition-based stats. Identities = 40/150 (26%), Positives = 61/150 (40%), Gaps = 14/150 (9%) Query: 38 LDLEELREYQRRKRTEYEGYLKRNR-LDMGQWIRYAQFEI----EQHDMRRARSIFERAL 92 D E L K T++ Y+ R LD + R A+ I R IFERA+ Sbjct: 41 SDFEHLVLAPGTKPTDFLNYVNWERSLDRLRAKRCARLNIRSVTSHASQARTFGIFERAV 100 Query: 93 LVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIV 152 L I LW+ Y++ +VK R +M RA+ P LW L + N ++ Sbjct: 101 LKHPGSIELWLAYLEFAAQVKATKRWRRIMTRALRLHPMNASLW--TLAGRRAAQNGDMQ 158 Query: 153 RSLY-----TKWCSLEPGVNAWNSFVDFEI 177 R+ ++C+ EP W + E+ Sbjct: 159 RARAHFLRGCRFCTREP--TLWLEYARCEM 186 Score = 44.5 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 27/174 (15%), Positives = 61/174 (35%), Gaps = 14/174 (8%) Query: 427 LGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGD 486 +++ + + I R I+E+ + P +++W Y E + Sbjct: 63 WERSLDRLRAKRCARLNIRSVTSHASQARTFGIFERAVLKHPGSIELWLAYLEFAAQVKA 122 Query: 487 WDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELNQYSPQ 546 R R I T AL L ++ + ++AR + R P Sbjct: 123 TKRWRRIMTRAL------RLHPMNASLWTLAGRRAAQNGDMQRARAHFLRGCRFCTREPT 176 Query: 547 SWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEEAIV 600 W+E+A + + LA+++++ + + + ++A + EE + Sbjct: 177 LWLEYARCE--------MDWLARMEAKKQGQGVRKGVNALEAIKATEGQEEGDI 222 Score = 34.5 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 16/135 (11%), Positives = 44/135 (32%), Gaps = 13/135 (9%) Query: 183 NGVREIYSKYVMAHP-QMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDM 241 I+ + V+ HP ++ WL ++ F + T+ R + + A+ +L + Sbjct: 90 ARTFGIFERAVLKHPGSIELWLAYLEFAAQVKATKRWRRIMTRALRLHPMNASLWTLAGR 149 Query: 242 EVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQF-GDINSIEET 300 A+ + +R+ A + L E + + + ++ Sbjct: 150 RAAQ-----------NGDMQRARAHFLRGCRFCTREPTLWLEYARCEMDWLARMEAKKQG 198 Query: 301 ISYKRKMEYETILSN 315 ++ + + Sbjct: 199 QGVRKGVNALEAIKA 213 >6G90-D nrPDB Length = 629 Score = 115 bits (286), Expect = 8e-26, Method: Composition-based stats. Identities = 53/266 (19%), Positives = 98/266 (36%), Gaps = 48/266 (18%) Query: 1 MDTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEG---- 56 ++ +EP Q L+D Q RG DI L ++ + + +Y Sbjct: 9 IEDIEPRPDALRGLDTQFLQDNTALVQAYRGLDWSDISSLTQMVDVIEQTVVKYGNPNDS 68 Query: 57 -----------YLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRY 105 L++ L G W R+A E + ++++ ++ ++ + + LW Y Sbjct: 69 IKLALETILWQILRKYPLLFGFWKRFATIEYQLFGLKKSIAVLATSVKWFPTSLELWCDY 128 Query: 106 IDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPG 165 L V C+N+ + NN EI + L K P Sbjct: 129 ----LNVLCVNNPNE---------------------TDFIRNNFEIAKDLIGKQFLSHP- 162 Query: 166 VNAWNSFVDFEIRQKNWNGVREIYSKYVMAHPQMQ---TWLKWVRFENRHGNTEFTRSVY 222 W+ F++FE+ QKNW+ V+ IY Y++ P Q + + +F N + TR++ Sbjct: 163 --FWDKFIEFEVGQKNWHNVQRIYE-YIIEVPLHQYARFFTSYKKFLNEKN-LKTTRNID 218 Query: 223 SLAIDTVANLQNLQIWSDMEVAKLVN 248 + T + + + N Sbjct: 219 IVLRKTQTTVNEIWQFESKIKQPFFN 244 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 26/152 (17%), Positives = 61/152 (40%), Gaps = 13/152 (8%) Query: 440 FKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGEL--EENLGDWDRVRGIYTIA 497 +K + +E +L + + +++ P+ L++W Y + N + D +R + IA Sbjct: 91 WKRFATIEYQLFGLKKSIAVLATSVKWFPTSLELWCDYLNVLCVNNPNETDFIRNNFEIA 150 Query: 498 LDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELNQYSPQSWIEFAMYQTS 557 D K+I FE + + +++Y +E+ + +A + Sbjct: 151 KDLIGKQFLSHPF---WDKFIEFEVGQKNWHNVQRIYEYIIEVPLHQ------YARF--F 199 Query: 558 TPTEQQLLDLAKLQSENVDEDIEFEITDENKL 589 T ++ L + + N+D + T N++ Sbjct: 200 TSYKKFLNEKNLKTTRNIDIVLRKTQTTVNEI 231 Score = 35.7 bits (80), Expect = 0.063, Method: Composition-based stats. Identities = 54/420 (12%), Positives = 128/420 (30%), Gaps = 57/420 (13%) Query: 168 AWNSFVDFEIRQKNWNGVREIYSKYVMAHP-QMQTWLKWVRFE--NRHGNTEFTRSVYSL 224 W F E + + + V P ++ W ++ N T+F R+ + + Sbjct: 90 FWKRFATIEYQLFGLKKSIAVLATSVKWFPTSLELWCDYLNVLCVNNPNETDFIRNNFEI 149 Query: 225 AIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIE--------KWPS 276 A D + + F +E Q+ + +Y+ IE + S Sbjct: 150 AKDLIGK--------QFLSHPFWDKFIEFEVGQKNWHNVQRIYEYIIEVPLHQYARFFTS 201 Query: 277 NQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAYDYDT--------WWLYLD 328 + + DI + + ++E+ + ++ W YL Sbjct: 202 YKKFLNEKNLKTTRNIDIVLRKTQTTVNEIWQFESKIKQPFFNLGQVLNDDLENWSRYLK 261 Query: 329 LISES----FPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLE 384 +++ + +M F++ ++ E + WM YI ++ + + + Sbjct: 262 FVTDPSKSLDKEFVMSVFDRCLIPCLYHENT-----------WMMYIKWLTKKNISDEVV 310 Query: 385 EELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRH--DDVPKARKILG----KAIGLCPKAK 438 +++Q+ + F + + +FL R + I + + + P Sbjct: 311 VDIYQKANTFLP----LDFKTLRYDFLRFLKRKYRSNNTLFNNIFNETVSRYLKIWPNDI 366 Query: 439 TFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIAL 498 +K F K I + + + D + T+ Sbjct: 367 LLMTEYLCMLKRHSFKNSLDQSPKEILEKQTSFTKILETSITNYINNQIDAKVHLQTLIN 426 Query: 499 DENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELNQYSPQSWIEFAMYQTST 558 D+N + E + + K LY++ + + P W+ + ++ S Sbjct: 427 DKNLSIVVVELIKTTW----LVLKNNMQTRKYFNLYQKNILIKNSVP-FWLTYYKFEKSN 481 >5JPZ-A nrPDB Length = 509 Score = 108 bits (269), Expect = 7e-24, Method: Composition-based stats. Identities = 52/273 (19%), Positives = 108/273 (39%), Gaps = 43/273 (15%) Query: 31 GSTNIDILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFER 90 I + + + + + E L+ + ++ Y FE++ D R + IFER Sbjct: 211 PIPESVIQNYNKALQQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFER 270 Query: 91 ALLVDSSFIPLWIR---YIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLI------ 141 AL+ + LWIR Y+D +LKVK + ++ NRAI P LW +YL+ Sbjct: 271 ALVENCLVPDLWIRYSQYLDRQLKVK--DLVLSVHNRAIRNCPWTVALWSRYLLAMERHG 328 Query: 142 VEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNG-----VREIYSKYVMAH 196 V+ + +V ++L + V W +++D+ R+ ++ + E+ + + A Sbjct: 329 VDHQVISVTFEKALNAGFIQATDYVEIWQAYLDYLRRRVDFKQDSSKELEELRAAFTRAL 388 Query: 197 PQMQTWLK----------------WVRFENR-HGNTEFTRSVYSLAIDTVANLQNLQIWS 239 ++ ++ W R E R N + R ++ ++ Sbjct: 389 EYLKQEVEERFNESGDPSCVIMQNWARIEARLCNNMQKARELW----------DSIMTRG 438 Query: 240 DMEVAKLVNSFAHWEAAQQEYERSSALYQIAIE 272 + + A + + + E A + + A++ Sbjct: 439 NAKYANMWLEYYNLERAHGDTQHCRKALHRAVQ 471 Score = 65.3 bits (157), Expect = 9e-11, Method: Composition-based stats. Identities = 70/492 (14%), Positives = 170/492 (34%), Gaps = 69/492 (14%) Query: 37 ILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDS 96 IL++E L E +Y +D+ + +R + ++ + R ++ + Sbjct: 30 ILEIERLEEQLSINVYDYN-----CHVDLIRLLRL------EGELTKVRMARQKMSEIFP 78 Query: 97 SFIPLWIRYIDAELKVKC----INHARNLMNRAIST--LPRVDKLWYKY-LIVEESLNNV 149 LW+ ++ E+ + H +L +A+ P + + +Y + + Sbjct: 79 LTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKDYICPNIWLEYGQYSVGGIGQKGGL 138 Query: 150 EIVRSLYTKWCSLEP-----GVNAWNSFVDFEIRQKNWNGVREIYSKYVM--AHPQMQTW 202 E VRS++ + S G+ W ++ +FE + +++S + A P Sbjct: 139 EKVRSVFERALSSVGLHMTKGLALWEAYREFESAIVEAARLEKVHSLFRRQLAIPLYDME 198 Query: 203 LKWVRFENRHGNT--EFTRSVYSLAIDTVANLQNLQ---IWSDMEVAKLVNSFAHWEAAQ 257 + +E + E Y+ A+ + + + + ++ ++ +E Sbjct: 199 ATFAEYEEWSEDPIPESVIQNYNKALQQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKI 258 Query: 258 QEYERSSALYQIA-IEKWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNN 316 + R +++ A +E L ++Q +++ + + + N Sbjct: 259 GDPARIQLIFERALVENCLVPDLWIRYSQYLDRQL----KVKDLV----LSVHNRAIRNC 310 Query: 317 AYDYDTWWLYLDLISES--FPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYV 374 + W YL + + I TFEKA+ + +Q Y+ +W Y+ Y+ Sbjct: 311 PWTVALWSRYLLAMERHGVDHQVISVTFEKAL-------NAGFIQATDYVEIWQAYLDYL 363 Query: 375 ELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLC 434 ++ Q ++ + + + + R ++ Sbjct: 364 RRRVD-------FKQDSSKELEELRAAFTRALEYLKQEVEERFNE------------SGD 404 Query: 435 PKAKTFKGYIELEVKL-KEFDRVRKIYEKFIEF-QPSDLQIWSQYGELEENLGDWDRVRG 492 P + + +E +L + R++++ + +W +Y LE GD R Sbjct: 405 PSCVIMQNWARIEARLCNNMQKARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCRK 464 Query: 493 IYTIALDENSDF 504 A+ SD+ Sbjct: 465 ALHRAVQCTSDY 476 Score = 54.6 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 46/278 (16%), Positives = 95/278 (34%), Gaps = 66/278 (23%) Query: 321 DTWWLYLD-----LISESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVE 375 + W Y + + +++ FE+A+ + + + LW Y + Sbjct: 119 NIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSV-------GLHMTKGLALWEAYREFES 171 Query: 376 --LELENSLLEEELFQRLIDDIIPHKHFTFSKI--WLMYAKFLIRHDDVPKARKILGKA- 430 +E LF+R + + TF++ W + KA + L K Sbjct: 172 AIVEAARLEKVHSLFRRQLAIPLYDMEATFAEYEEWSEDPIPESVIQNYNKALQQLEKYK 231 Query: 431 -------IGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGE-LEE 482 P+ ++ YI+ E+K+ + R++ I+E+ + +W +Y + L+ Sbjct: 232 PYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERALVENCLVPDLWIRYSQYLDR 291 Query: 483 NLGDWDRVRGI-----------------YTIALDE----------------NSDFLTKEA 509 L D V + Y +A++ N+ F+ Sbjct: 292 QLKVKDLVLSVHNRAIRNCPWTVALWSRYLLAMERHGVDHQVISVTFEKALNAGFIQATD 351 Query: 510 KIVLLQKYITFETE--------SQEFEKARKLYRRYLE 539 + + Q Y+ + S+E E+ R + R LE Sbjct: 352 YVEIWQAYLDYLRRRVDFKQDSSKELEELRAAFTRALE 389 Score = 31.5 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 33/197 (16%), Positives = 65/197 (32%), Gaps = 20/197 (10%) Query: 438 KTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLG----DWDRVRGI 493 I L E +VR +K E P ++W ++ E ++ D + V + Sbjct: 48 NCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEISMAQDGLDREHVYDL 107 Query: 494 YTIALDENSDFLTKEAKIVLLQKYITFET----ESQEFEKARKLYRRYLELNQYSPQSWI 549 + A+ + +Y + + EK R ++ R L Sbjct: 108 FEKAVK-------DYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMT--K 158 Query: 550 EFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEEAI---VFFKEKD 606 A+++ E +++ A+L+ + + I + +EE + Sbjct: 159 GLALWEAYREFESAIVEAARLEKVHSLFRRQLAIPLYDMEATFAEYEEWSEDPIPESVIQ 218 Query: 607 DKQGRLSILEALKDYEE 623 + L LE K YEE Sbjct: 219 NYNKALQQLEKYKPYEE 235 >5CTQ-A nrPDB Length = 561 Score = 105 bits (262), Expect = 6e-23, Method: Composition-based stats. Identities = 52/273 (19%), Positives = 108/273 (39%), Gaps = 43/273 (15%) Query: 31 GSTNIDILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFER 90 I + + + + + E L+ + ++ Y FE++ D R + IFER Sbjct: 226 PIPESVIQNYNKALQQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFER 285 Query: 91 ALLVDSSFIPLWIR---YIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLI------ 141 AL+ + LWIR Y+D +LKVK + ++ NRAI P LW +YL+ Sbjct: 286 ALVENCLVPDLWIRYSQYLDRQLKVK--DLVLSVHNRAIRNCPWTVALWSRYLLAMERHG 343 Query: 142 VEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNG-----VREIYSKYVMAH 196 V+ + +V ++L + V W +++D+ R+ ++ + E+ + + A Sbjct: 344 VDHQVISVTFEKALNAGFIQATDYVEIWQAYLDYLRRRVDFKQDSSKELEELRAAFTRAL 403 Query: 197 PQMQTWLK----------------WVRFENR-HGNTEFTRSVYSLAIDTVANLQNLQIWS 239 ++ ++ W R E R N + R ++ ++ Sbjct: 404 EYLKQEVEERFNESGDPSCVIMQNWARIEARLCNNMQKARELW----------DSIMTRG 453 Query: 240 DMEVAKLVNSFAHWEAAQQEYERSSALYQIAIE 272 + + A + + + E A + + A++ Sbjct: 454 NAKYANMWLEYYNLERAHGDTQHCRKALHRAVQ 486 Score = 61.9 bits (148), Expect = 9e-10, Method: Composition-based stats. Identities = 66/477 (13%), Positives = 161/477 (33%), Gaps = 58/477 (12%) Query: 52 TEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELK 111 E L N D + + + ++ + R ++ + LW+ ++ E+ Sbjct: 49 ERLEEQLSINVYDYNCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEIS 108 Query: 112 VKC----INHARNLMNRAIST--LPRVDKLWYKY-LIVEESLNNVEIVRSLYTKWCSLEP 164 + H +L +A+ P + + +Y + +E VRS++ + S Sbjct: 109 MAQDGLDREHVYDLFEKAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVG 168 Query: 165 -----GVNAWNSFVDFEIRQKNWNGVREIYSKYVM--AHPQMQTWLKWVRFENRHGNT-- 215 G+ W ++ +FE + +++S + A P + +E + Sbjct: 169 LHMTKGLALWEAYREFESAIVEAARLEKVHSLFRRQLAIPLYDMEATFAEYEEWSEDPIP 228 Query: 216 EFTRSVYSLAIDTVANLQNLQ---IWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIA-I 271 E Y+ A+ + + + + ++ ++ +E + R +++ A + Sbjct: 229 ESVIQNYNKALQQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERALV 288 Query: 272 EKWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLIS 331 E L ++Q +++ + + + N + W YL + Sbjct: 289 ENCLVPDLWIRYSQYLDRQL----KVKDLV----LSVHNRAIRNCPWTVALWSRYLLAME 340 Query: 332 ES--FPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQ 389 + I TFEKA+ + +Q Y+ +W Y+ Y+ ++ Q Sbjct: 341 RHGVDHQVISVTFEKAL-------NAGFIQATDYVEIWQAYLDYLRRRVD-------FKQ 386 Query: 390 RLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVK 449 ++ + + + + R ++ P + + +E + Sbjct: 387 DSSKELEELRAAFTRALEYLKQEVEERFNE------------SGDPSCVIMQNWARIEAR 434 Query: 450 L-KEFDRVRKIYEKFIEF-QPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDF 504 L + R++++ + +W +Y LE GD R A+ SD+ Sbjct: 435 LCNNMQKARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCRKALHRAVQCTSDY 491 Score = 52.6 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 36/222 (16%), Positives = 77/222 (34%), Gaps = 31/222 (13%) Query: 321 DTWWLYLD-----LISESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVE 375 + W Y + + +++ FE+A+ + + + LW Y + Sbjct: 134 NIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSV-------GLHMTKGLALWEAYREFES 186 Query: 376 --LELENSLLEEELFQRLIDDIIPHKHFTFSKI--WLMYAKFLIRHDDVPKARKILGKA- 430 +E LF+R + + TF++ W + KA + L K Sbjct: 187 AIVEAARLEKVHSLFRRQLAIPLYDMEATFAEYEEWSEDPIPESVIQNYNKALQQLEKYK 246 Query: 431 -------IGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGE-LEE 482 P+ ++ YI+ E+K+ + R++ I+E+ + +W +Y + L+ Sbjct: 247 PYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERALVENCLVPDLWIRYSQYLDR 306 Query: 483 NLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETES 524 L D V ++ N + L +Y+ Sbjct: 307 QLKVKDLVLSVH------NRAIRNCPWTVALWSRYLLAMERH 342 Score = 32.2 bits (71), Expect = 0.82, Method: Composition-based stats. Identities = 35/236 (14%), Positives = 74/236 (31%), Gaps = 28/236 (11%) Query: 399 KHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRK 458 + F ++ + I + + + I L E +VR Sbjct: 32 RGSEFENLYFQGNQLEIERLEEQLSINVY--------DYNCHVDLIRLLRLEGELTKVRM 83 Query: 459 IYEKFIEFQPSDLQIWSQYGELEENLG----DWDRVRGIYTIALDENSDFLTKEAKIVLL 514 +K E P ++W ++ E ++ D + V ++ A+ + Sbjct: 84 ARQKMSEIFPLTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVK-------DYICPNIW 136 Query: 515 QKYITFET----ESQEFEKARKLYRRYLELNQYSPQSWIEFAMYQTSTPTEQQLLDLAKL 570 +Y + + EK R ++ R L A+++ E +++ A+L Sbjct: 137 LEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMT--KGLALWEAYREFESAIVEAARL 194 Query: 571 QSENVDEDIEFEITDENKLEARKVFEEAI---VFFKEKDDKQGRLSILEALKDYEE 623 + + + I + +EE + + L LE K YEE Sbjct: 195 EKVHSLFRRQLAIPLYDMEATFAEYEEWSEDPIPESVIQNYNKALQQLEKYKPYEE 250 >5JJW-A nrPDB Length = 300 Score = 105 bits (261), Expect = 7e-23, Method: Composition-based stats. Identities = 54/261 (20%), Positives = 109/261 (41%), Gaps = 44/261 (16%) Query: 43 LREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLW 102 L++ ++ K E E L+ + ++ Y FE++ D R + IFERAL+ + LW Sbjct: 11 LQQLEKYKPYE-EALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERALVENCLVPDLW 69 Query: 103 IR---YIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLI------VEESLNNVEIVR 153 IR Y+D +LKVK + ++ NRAI P LW +YL+ V+ + +V + Sbjct: 70 IRYSQYLDRQLKVK--DLVLSVHNRAIRNCPWTVALWSRYLLAMERHGVDHQVISVTFEK 127 Query: 154 SLYTKWCSLEPGVNAWNSFVDFEIRQKNWNG-----VREIYSKYVMAHPQMQTWLK---- 204 +L + V W +++D+ R+ ++ + E+ + + A ++ ++ Sbjct: 128 ALNAGFIQATDYVEIWQAYLDYLRRRVDFKQDSSKELEELRAAFTRALEYLKQEVEERFN 187 Query: 205 ------------WVRFENR-HGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFA 251 W R E R N + R ++ ++ + + A + + Sbjct: 188 ESGDPSCVIMQNWARIEARLCNNMQKARELW----------DSIMTRGNAKYANMWLEYY 237 Query: 252 HWEAAQQEYERSSALYQIAIE 272 + E A + + A++ Sbjct: 238 NLERAHGDTQHCRKALHRAVQ 258 Score = 42.6 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 39/291 (13%), Positives = 97/291 (33%), Gaps = 42/291 (14%) Query: 222 YSLAIDTVANLQNLQ---IWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIA-IEKWPSN 277 Y+ A+ + + + + ++ ++ +E + R +++ A +E Sbjct: 7 YNKALQQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERALVENCLVP 66 Query: 278 QLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISES--FP 335 L ++Q +++ + + + N + W YL + Sbjct: 67 DLWIRYSQYLDRQL----KVKDLV----LSVHNRAIRNCPWTVALWSRYLLAMERHGVDH 118 Query: 336 KQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRLIDDI 395 + I TFEKA+ + +Q Y+ +W Y+ Y+ ++ Q ++ Sbjct: 119 QVISVTFEKAL-------NAGFIQATDYVEIWQAYLDYLRRRVD-------FKQDSSKEL 164 Query: 396 IPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKL-KEFD 454 + + + + R ++ P + + +E +L Sbjct: 165 EELRAAFTRALEYLKQEVEERFNE------------SGDPSCVIMQNWARIEARLCNNMQ 212 Query: 455 RVRKIYEKFIEF-QPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDF 504 + R++++ + +W +Y LE GD R A+ SD+ Sbjct: 213 KARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCRKALHRAVQCTSDY 263 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 37/248 (14%), Positives = 82/248 (33%), Gaps = 27/248 (10%) Query: 195 AHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWE 254 P++ + ++ FE + G+ + ++ A+ + +L I + + Sbjct: 28 EAPRLAEYQAYIDFEMKIGDPARIQLIFERALVENCLVPDLWIRYSQ----------YLD 77 Query: 255 AAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILS 314 + + +++ AI P L + L ++ G + K + Sbjct: 78 RQLKVKDLVLSVHNRAIRNCPWTVALWSRYLLAMERHG--VDHQVISVTFEKALNAGFIQ 135 Query: 315 NNAYDYDTWWLYLDL---------ISESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIY 365 Y + W YLD S +++ F +A+ K+ + + Sbjct: 136 ATDY-VEIWQAYLDYLRRRVDFKQDSSKELEELRAAFTRALEYL--KQEVEERFNESGDP 192 Query: 366 LWMRYICYVELELENSLLEEELFQRLI-DDIIPHKHFTFSKIWLMYAKFLIRHDDVPKAR 424 + + +E L R + D I+ + ++ +WL Y H D R Sbjct: 193 SCVIMQNWARIEA--RLCNNMQKARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCR 250 Query: 425 KILGKAIG 432 K L +A+ Sbjct: 251 KALHRAVQ 258 Score = 38.0 bits (86), Expect = 0.013, Method: Composition-based stats. Identities = 22/116 (18%), Positives = 47/116 (40%), Gaps = 9/116 (7%) Query: 410 YAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPS 469 Y K L + + + L +A P+ ++ YI+ E+K+ + R++ I+E+ + Sbjct: 7 YNKALQQLEKYKPYEEALLQA--EAPRLAEYQAYIDFEMKIGDPARIQLIFERALVENCL 64 Query: 470 DLQIWSQYGE-LEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETES 524 +W +Y + L+ L D V ++ N + L +Y+ Sbjct: 65 VPDLWIRYSQYLDRQLKVKDLVLSVH------NRAIRNCPWTVALWSRYLLAMERH 114 >5CTR-A nrPDB Length = 338 Score = 100 bits (248), Expect = 2e-21, Method: Composition-based stats. Identities = 52/271 (19%), Positives = 108/271 (39%), Gaps = 43/271 (15%) Query: 33 TNIDILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERAL 92 I + + + + + E L+ + ++ Y FE++ D R + IFERAL Sbjct: 5 PESVIQNYNKALQQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERAL 64 Query: 93 LVDSSFIPLWIR---YIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLI------VE 143 + + LWIR Y+D +LKVK + ++ NRAI P LW +YL+ V+ Sbjct: 65 VENCLVPDLWIRYSQYLDRQLKVK--DLVLSVHNRAIRNCPWTVALWSRYLLAMERHGVD 122 Query: 144 ESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNG-----VREIYSKYVMAHPQ 198 + +V ++L + V W +++D+ R+ ++ + E+ + + A Sbjct: 123 HQVISVTFEKALNAGFIQATDYVEIWQAYLDYLRRRVDFKQDSSKELEELRAAFTRALEY 182 Query: 199 MQTWLK----------------WVRFENR-HGNTEFTRSVYSLAIDTVANLQNLQIWSDM 241 ++ ++ W R E R N + R ++ ++ + Sbjct: 183 LKQEVEERFNESGDPSCVIMQNWARIEARLCNNMQKARELW----------DSIMTRGNA 232 Query: 242 EVAKLVNSFAHWEAAQQEYERSSALYQIAIE 272 + A + + + E A + + A++ Sbjct: 233 KYANMWLEYYNLERAHGDTQHCRKALHRAVQ 263 Score = 39.5 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 47/318 (14%), Positives = 101/318 (31%), Gaps = 37/318 (11%) Query: 195 AHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWE 254 P++ + ++ FE + G+ + ++ A+ + +L I + + Sbjct: 33 EAPRLAEYQAYIDFEMKIGDPARIQLIFERALVENCLVPDLWIRYSQ----------YLD 82 Query: 255 AAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILS 314 + + +++ AI P L + L ++ G + K + Sbjct: 83 RQLKVKDLVLSVHNRAIRNCPWTVALWSRYLLAMERHG--VDHQVISVTFEKALNAGFIQ 140 Query: 315 NNAYDYDTWWLYLDL---------ISESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIY 365 Y + W YLD S +++ F +A+ K+ + + Sbjct: 141 ATDY-VEIWQAYLDYLRRRVDFKQDSSKELEELRAAFTRALEYL--KQEVEERFNESGDP 197 Query: 366 LWMRYICYVELELENSLLEEELFQRLI-DDIIPHKHFTFSKIWLMYAKFLIRHDDVPKAR 424 + + +E L R + D I+ + ++ +WL Y H D R Sbjct: 198 SCVIMQNWARIEA--RLCNNMQKARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCR 255 Query: 425 KILGKAIGLCPK-----AKTFKGYIELEVKLKEFD-RVRKIYEKFIEFQPSDLQIWSQYG 478 K L +A+ + E L+++D V+K + ++ + Sbjct: 256 KALHRAVQCTSDYPEHVCEVLLTMERTEGSLEDWDIAVQKTETRLARVNEQRMKAAEKEA 315 Query: 479 EL----EENLGDWDRVRG 492 L EE R R Sbjct: 316 ALVQQEEEKAEQRKRARA 333 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 39/291 (13%), Positives = 97/291 (33%), Gaps = 42/291 (14%) Query: 222 YSLAIDTVANLQNLQ---IWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIA-IEKWPSN 277 Y+ A+ + + + + ++ ++ +E + R +++ A +E Sbjct: 12 YNKALQQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERALVENCLVP 71 Query: 278 QLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISES--FP 335 L ++Q +++ + + + N + W YL + Sbjct: 72 DLWIRYSQYLDRQL----KVKDLV----LSVHNRAIRNCPWTVALWSRYLLAMERHGVDH 123 Query: 336 KQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRLIDDI 395 + I TFEKA+ + +Q Y+ +W Y+ Y+ ++ Q ++ Sbjct: 124 QVISVTFEKAL-------NAGFIQATDYVEIWQAYLDYLRRRVD-------FKQDSSKEL 169 Query: 396 IPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKL-KEFD 454 + + + + R ++ P + + +E +L Sbjct: 170 EELRAAFTRALEYLKQEVEERFNE------------SGDPSCVIMQNWARIEARLCNNMQ 217 Query: 455 RVRKIYEKFIEF-QPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDF 504 + R++++ + +W +Y LE GD R A+ SD+ Sbjct: 218 KARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCRKALHRAVQCTSDY 268 Score = 36.5 bits (82), Expect = 0.041, Method: Composition-based stats. Identities = 22/116 (18%), Positives = 47/116 (40%), Gaps = 9/116 (7%) Query: 410 YAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPS 469 Y K L + + + L +A P+ ++ YI+ E+K+ + R++ I+E+ + Sbjct: 12 YNKALQQLEKYKPYEEALLQA--EAPRLAEYQAYIDFEMKIGDPARIQLIFERALVENCL 69 Query: 470 DLQIWSQYGE-LEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETES 524 +W +Y + L+ L D V ++ N + L +Y+ Sbjct: 70 VPDLWIRYSQYLDRQLKVKDLVLSVH------NRAIRNCPWTVALWSRYLLAMERH 119 >6G70-A nrPDB Length = 670 Score = 89.2 bits (219), Expect = 5e-18, Method: Composition-based stats. Identities = 72/502 (14%), Positives = 159/502 (31%), Gaps = 38/502 (7%) Query: 37 ILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDS 96 +L E + R ++ + G W +YA E +++++ ++ R L Sbjct: 104 LLQYVEQENHLMAARKAFDKFFVHYPYCYGYWKKYADLEKRHDNIKQSDEVYRRGLQAIP 163 Query: 97 SFIPLWIRYIDA---------ELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLN 147 + LWI YI+ + I A T R DKLW Y+ E Sbjct: 164 LSVDLWIHYINFLKETLDPGDQETNTTIRGTFEHAVLAAGTDFRSDKLWEMYINWENEQG 223 Query: 148 NVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNGVREIYSKYVMAHPQMQTWLKWVR 207 N+ V ++Y + + + + + ++ + + + +Q + Sbjct: 224 NLREVTAVYDRILGIPTQLYSHH------FQRFKEHVQNNLPRDLLTGEQFIQLRRELAS 277 Query: 208 FENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAH-WEAAQQEYERSSAL 266 G+ I+ + + L + +++ + + E + Sbjct: 278 VNGHSGDDGPPGDDLPSGIEDITDPAKLITEIENMRHRIIEIHQEMFNYNEHEVSKRWTF 337 Query: 267 YQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAYDYDTWWLY 326 + + + L+ L K++ + IE + + +E + + A + W Y Sbjct: 338 EEGIKRPYFHVKPLEKAQLKNWKEYLEF-EIENGTHERVVVLFERCVISCALYEEFWIKY 396 Query: 327 LDLISESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEE 386 + + + F +A PK+ ++ W + E + + E Sbjct: 397 AKYMENHSIEGVRHVFSRACTVHLPKKPMAHMLWAAF-------------EEQQGNINE- 442 Query: 387 LFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAK-----TFK 441 R+I + + L RH ++ +A +L AI K Sbjct: 443 --ARIILRTFEECVLGLAMVRLRRVSLERRHGNMEEAEHLLQDAIKNAKSNNESSFYAIK 500 Query: 442 GYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDEN 501 L K + RK+ + IE + +++ E+E + I Sbjct: 501 LARHLFKIQKNLPKSRKVLLEAIEKDKENTKLYLNLLEMEYSCDLKQNEENILNCFDKAI 560 Query: 502 SDFLTKEAKIVLLQKYITFETE 523 L + +I Q+ + F + Sbjct: 561 HGSLPIKMRITFSQRKVEFLED 582 Score = 65.0 bits (156), Expect = 1e-10, Method: Composition-based stats. Identities = 89/607 (14%), Positives = 197/607 (32%), Gaps = 77/607 (12%) Query: 110 LKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEP-GVNA 168 + V + + + A ++ + L V E+ + + K + P Sbjct: 41 MNVTEMEQSPDASPSAHASTEENEMANAVNLPVTEAEGDFPPEFEKFWKTVEMNPQDFTG 100 Query: 169 WNSFVDFEIRQKNWNGVREIYSKYVMAHPQ-MQTWLKWVRFENRHGNTEFTRSVYSLAID 227 W + + ++ + R+ + K+ + +P W K+ E RH N + + VY + Sbjct: 101 WVYLLQYVEQENHLMAARKAFDKFFVHYPYCYGYWKKYADLEKRHDNIKQSDEVYRRGLQ 160 Query: 228 TVANLQNLQIW--------------------------------SDMEVAKLVNSFAHWEA 255 + +L I +D KL + +WE Sbjct: 161 AIPLSVDLWIHYINFLKETLDPGDQETNTTIRGTFEHAVLAAGTDFRSDKLWEMYINWEN 220 Query: 256 AQQEYERSSALYQIAIEKWPS--NQLLKAGLLDFEKQFG-DINSIEETISYKRKMEYETI 312 Q +A+Y + + + + D+ + E+ I +R++ Sbjct: 221 EQGNLREVTAVYDRILGIPTQLYSHHFQRFKEHVQNNLPRDLLTGEQFIQLRRELASVNG 280 Query: 313 LSNN--------AYDYDTWWLYLDLISE---------SFPKQIMQTFEKAIVDSRPKELS 355 S + + LI+E +++ E + E Sbjct: 281 HSGDDGPPGDDLPSGIEDITDPAKLITEIENMRHRIIEIHQEMFNYNEHEVSKRWTFEEG 340 Query: 356 KNVQWKRYIYL----WMRYICYVELELENSLLEE--ELFQRLIDDIIPHKHFTFSKIWLM 409 + L + Y+E E+EN E LF+R + ++ F W+ Sbjct: 341 IKRPYFHVKPLEKAQLKNWKEYLEFEIENGTHERVVVLFERCVISCALYEEF-----WIK 395 Query: 410 YAKFLIRHDDVPKARKILGKAIG--LCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQ 467 YAK++ H + R + +A L K + E + + R I F E Sbjct: 396 YAKYMENH-SIEGVRHVFSRACTVHLPKKPMAHMLWAAFEEQQGNINEARIILRTFEECV 454 Query: 468 PSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEF 527 + + LE G+ + + A+ +N+ + + + F+ + Sbjct: 455 LGLAMVRLRRVSLERRHGNMEEAEHLLQDAI-KNAKSNNESSFYAIKLARHLFKI-QKNL 512 Query: 528 EKARKLYRRYLELNQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDEN 587 K+RK+ +E ++ + + ++ + S +Q ++ + + + ++ Sbjct: 513 PKSRKVLLEAIEKDKENTKLYLNLLEMEYSCDLKQNEENILNCFDKAIHGSLPIKMRITF 572 Query: 588 KLEARKVFE----EAIVFFKEKDDKQGRLSILEALKDYEETYGTELDQETVKKRFPKVIK 643 + E + D+ Q L + LK E G+E +E KK + + Sbjct: 573 SQRKVEFLEDFGSDVNKLLNAYDEHQTLLKEQDTLKRKAEN-GSEEPEE--KKAHTEDLS 629 Query: 644 KVRLQNG 650 ++ +G Sbjct: 630 SAQIIDG 636 >5IC8-A nrPDB Length = 334 Score = 89.2 bits (219), Expect = 6e-18, Method: Composition-based stats. Identities = 28/106 (26%), Positives = 44/106 (41%), Gaps = 9/106 (8%) Query: 77 EQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLW 136 R IFERA+L I LW+ Y++ +VK R +M RA+ P LW Sbjct: 5 SHASQARTFGIFERAVLKHPGSIELWLAYLEFAAQVKATKRWRRIMTRALRLHPMNASLW 64 Query: 137 YKYLIVEESLNNVEIVRSLY-----TKWCSLEPGVNAWNSFVDFEI 177 L + N ++ R+ ++C+ EP W + E+ Sbjct: 65 --TLAGRRAAQNGDMQRARAHFLRGCRFCTREP--TLWLEYARCEM 106 Score = 53.4 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 20/90 (22%), Positives = 33/90 (36%) Query: 54 YEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVK 113 +E + ++ + W+ Y +F + +R R I RAL + LW + Sbjct: 16 FERAVLKHPGSIELWLAYLEFAAQVKATKRWRRIMTRALRLHPMNASLWTLAGRRAAQNG 75 Query: 114 CINHARNLMNRAISTLPRVDKLWYKYLIVE 143 + AR R R LW +Y E Sbjct: 76 DMQRARAHFLRGCRFCTREPTLWLEYARCE 105 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 18/91 (19%), Positives = 36/91 (39%), Gaps = 1/91 (1%) Query: 392 IDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYI-ELEVKL 450 I + KH ++WL Y +F + + R+I+ +A+ L P + + Sbjct: 15 IFERAVLKHPGSIELWLAYLEFAAQVKATKRWRRIMTRALRLHPMNASLWTLAGRRAAQN 74 Query: 451 KEFDRVRKIYEKFIEFQPSDLQIWSQYGELE 481 + R R + + F + +W +Y E Sbjct: 75 GDMQRARAHFLRGCRFCTREPTLWLEYARCE 105 Score = 41.1 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 16/73 (21%), Positives = 30/73 (41%) Query: 38 LDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSS 97 L+ + +R R L+ + ++ W + + DM+RAR+ F R + Sbjct: 34 LEFAAQVKATKRWRRIMTRALRLHPMNASLWTLAGRRAAQNGDMQRARAHFLRGCRFCTR 93 Query: 98 FIPLWIRYIDAEL 110 LW+ Y E+ Sbjct: 94 EPTLWLEYARCEM 106 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 23/109 (21%), Positives = 42/109 (38%), Gaps = 7/109 (6%) Query: 416 RHDDVPKARKILGKAIGLCPKA-KTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIW 474 H + I +A+ P + + + Y+E ++K R R+I + + P + +W Sbjct: 5 SHASQARTFGIFERAVLKHPGSIELWLAYLEFAAQVKATKRWRRIMTRALRLHPMNASLW 64 Query: 475 SQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETE 523 + G GD R R + F T+E L +Y E + Sbjct: 65 TLAGRRAAQNGDMQRARAHFL----RGCRFCTREP--TLWLEYARCEMD 107 Score = 36.1 bits (81), Expect = 0.054, Method: Composition-based stats. Identities = 16/135 (11%), Positives = 44/135 (32%), Gaps = 13/135 (9%) Query: 183 NGVREIYSKYVMAHP-QMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDM 241 I+ + V+ HP ++ WL ++ F + T+ R + + A+ +L + Sbjct: 10 ARTFGIFERAVLKHPGSIELWLAYLEFAAQVKATKRWRRIMTRALRLHPMNASLWTLAGR 69 Query: 242 EVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQF-GDINSIEET 300 A+ + +R+ A + L E + + + ++ Sbjct: 70 RAAQ-----------NGDMQRARAHFLRGCRFCTREPTLWLEYARCEMDWLARMEAKKQG 118 Query: 301 ISYKRKMEYETILSN 315 ++ + + Sbjct: 119 QGVRKGVNALEAIKA 133 >5JJX-A nrPDB Length = 314 Score = 81.9 bits (200), Expect = 9e-16, Method: Composition-based stats. Identities = 34/120 (28%), Positives = 55/120 (45%), Gaps = 5/120 (4%) Query: 31 GSTNIDILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFER 90 I + + + + + E L+ + ++ Y FE++ D R + IFER Sbjct: 197 PIPESVIQNYNKALQQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFER 256 Query: 91 ALLVDSSFIPLWIR---YIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLN 147 AL+ + LWIR Y+D +LKVK + ++ NRAI P LW +YL+ E Sbjct: 257 ALVENCLVPDLWIRYSQYLDRQLKVK--DLVLSVHNRAIRNCPWTVALWSRYLLAMERHG 314 Score = 54.2 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 36/222 (16%), Positives = 77/222 (34%), Gaps = 31/222 (13%) Query: 321 DTWWLYLD-----LISESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVE 375 + W Y + + +++ FE+A+ + + + LW Y + Sbjct: 105 NIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSV-------GLHMTKGLALWEAYREFES 157 Query: 376 --LELENSLLEEELFQRLIDDIIPHKHFTFSKI--WLMYAKFLIRHDDVPKARKILGKA- 430 +E LF+R + + TF++ W + KA + L K Sbjct: 158 AIVEAARLEKVHSLFRRQLAIPLYDMEATFAEYEEWSEDPIPESVIQNYNKALQQLEKYK 217 Query: 431 -------IGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGE-LEE 482 P+ ++ YI+ E+K+ + R++ I+E+ + +W +Y + L+ Sbjct: 218 PYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERALVENCLVPDLWIRYSQYLDR 277 Query: 483 NLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETES 524 L D V ++ N + L +Y+ Sbjct: 278 QLKVKDLVLSVH------NRAIRNCPWTVALWSRYLLAMERH 313 Score = 49.2 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 42/209 (20%), Positives = 83/209 (39%), Gaps = 23/209 (11%) Query: 366 LWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLI----RHDDVP 421 LW+ + + E+ + L+ E L + + K + IWL Y ++ + + + Sbjct: 69 LWLEW-LHDEISMAQDGLDREHVYDLFEKAV--KDYICPNIWLEYGQYSVGGIGQKGGLE 125 Query: 422 KARKILGKAIG-----LCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDL-QIWS 475 K R + +A+ + ++ Y E E + E R+ K++ F L + + Sbjct: 126 KVRSVFERALSSVGLHMTKGLALWEAYREFESAIVEAARLEKVHSLFRRQLAIPLYDMEA 185 Query: 476 QYGELEENLGDW--DRVRGIYTIALDENSDFLT--------KEAKIVLLQKYITFETESQ 525 + E EE D + V Y AL + + + ++ Q YI FE + Sbjct: 186 TFAEYEEWSEDPIPESVIQNYNKALQQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIG 245 Query: 526 EFEKARKLYRRYLELNQYSPQSWIEFAMY 554 + + + ++ R L N P WI ++ Y Sbjct: 246 DPARIQLIFERALVENCLVPDLWIRYSQY 274 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 46/338 (13%), Positives = 103/338 (30%), Gaps = 72/338 (21%) Query: 165 GVNAWNSFVDFEIRQKNWNGVREIYSKYVMAHPQMQ-TWLKWVRFENRHGNT----EFTR 219 N + + VR K P + WL+W+ E E Sbjct: 32 DYNCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEISMAQDGLDREHVY 91 Query: 220 SVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEA----AQQEYERSSALYQIAIE--- 272 ++ A+ D + + + + E+ ++++ A+ Sbjct: 92 DLFEKAVK------------DYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVG 139 Query: 273 -KWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAYDYDTWWL-YLDLI 330 L +FE + +E+ S R+ + YD + + Y + Sbjct: 140 LHMTKGLALWEAYREFESAIVEAARLEKVHSLFRRQLAIPL-----YDMEATFAEYEEWS 194 Query: 331 SESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELE--NSLLEEELF 388 + P+ ++Q + KA+ + + + Y Y++ E++ + + +F Sbjct: 195 EDPIPESVIQNYNKALQQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIF 254 Query: 389 QRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDV-PKARKILGKAIGLCPKAKTFKGYIELE 447 +R + + + +W+ Y+++L R V + +AI C Sbjct: 255 ERALVE-----NCLVPDLWIRYSQYLDRQLKVKDLVLSVHNRAIRNC------------- 296 Query: 448 VKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLG 485 P + +WS+Y E G Sbjct: 297 --------------------PWTVALWSRYLLAMERHG 314 Score = 44.2 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 39/239 (16%), Positives = 90/239 (37%), Gaps = 36/239 (15%) Query: 35 IDILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEI----EQHDMRRARSIFER 90 D LD E + + + +Y + W+ Y Q+ + ++ + + RS+FER Sbjct: 82 QDGLDREHVYDLFEKAVKDY--------ICPNIWLEYGQYSVGGIGQKGGLEKVRSVFER 133 Query: 91 AL----LVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTLP----------RVDKLW 136 AL L + + LW Y + E + + + L + W Sbjct: 134 ALSSVGLHMTKGLALWEAYREFESAIVEAARLEKVHSLFRRQLAIPLYDMEATFAEYEEW 193 Query: 137 YKYLIVEESLNNVEIVRSLYTKWCSLE--------PGVNAWNSFVDFEIRQKNWNGVREI 188 + I E + N K+ E P + + +++DFE++ + ++ I Sbjct: 194 SEDPIPESVIQNYNKALQQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLI 253 Query: 189 YSKYVMAHPQM-QTWLKWVRFENRHGNTEF-TRSVYSLAIDTVANLQNLQIWSDMEVAK 245 + + ++ + + W+++ ++ +R + SV++ AI L + + + Sbjct: 254 FERALVENCLVPDLWIRYSQYLDRQLKVKDLVLSVHNRAIRNCPWTVALWSRYLLAMER 312 >3JCM-G nrPDB Length = 899 Score = 72.7 bits (176), Expect = 5e-13, Method: Composition-based stats. Identities = 89/623 (14%), Positives = 200/623 (32%), Gaps = 104/623 (16%) Query: 17 QILRDVYKKGQKARGSTNIDILDLEELREYQRR---KRTEYEGYLKRNRLDMGQWIRYAQ 73 Q +R + K +KA + + L E R+ + E + W+ + Sbjct: 224 QKMRTILKSYRKADPTNPQGWIASARLEEKARKFSVAKKIIENGCQECPRSSDIWLENIR 283 Query: 74 FEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVD 133 D+ +++ A+ + + LW + ID E +N R ++ +A+ +PR + Sbjct: 284 LHES--DVHYCKTLVATAINFNPTSPLLWFKAIDLE--STTVNKYR-VVRKALQEIPRDE 338 Query: 134 KLWYKYLIVE-ESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNGVREI---- 188 LW + E + ++++ + A+ + + + N R+I Sbjct: 339 GLWKLAVSFEADKAQVIKMLEKATQFIPQSMDLLTAYTNLQSYHNAKMTLNSFRKILPQE 398 Query: 189 -----YSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQ---NLQIWSD 240 S + + + + G E +++ Y + N S+ Sbjct: 399 PEIWIISTLLEERNNPDIPVDKLVSLLKEGLLELSKNGYKATLSAWLKRAEALNDAPNSN 458 Query: 241 MEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQL-------LKAGLLDFEKQFGD 293 + +V + W EYE +EK P +++ L + Sbjct: 459 LTCQAIVYAILEWLRESGEYESELNNVDQILEKMPHSKVQIAVLKKLIQWDPCDTVLWSR 518 Query: 294 IN-------SIEETISYKRKMEY----ETILSNN-------------------------- 316 + IEE +++ +++ + + N Sbjct: 519 LKMATESYHKIEELLAFFQELLFQTKNSDDIRANMREKSPGLLMMYVSEYWKAQKGDTRQ 578 Query: 317 ------------AYDYDTWWLYLDLISES-FPKQIMQTFEKAIVDSRPKELSKNVQWKRY 363 ++ D + + L+ S ++ F++ ++S +R Sbjct: 579 TLVLIDQIIDFAPHNLDLRFFKIKLLGRSLQLDELRDFFQQTFSSLEDFKISGT---ERL 635 Query: 364 IYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKA 423 Y ++ ++ Y +L E + P H K +L + ++ + Sbjct: 636 YYKYVNFLRYQDLNEEAI----KFLNERCLKSFPICH----KFFLQLGQIYHSMGNIEMS 687 Query: 424 RKILGKAIGLCPKAKTFKGYIEL--EVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELE 481 R+ L P + E+ LK R R I ++ + P D+ + ++E Sbjct: 688 RETYLSGTRLVPNCPLLWVSLSKIDEIDLKNPVRARSILDRGLLKNPDDVLFYIAKIQME 747 Query: 482 ENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELN 541 LG+ D+ + T AL + + +L + I + + +++ L Sbjct: 748 IRLGNLDQAELLVTQALQKF------PSNALLWVEQIKLFKHGNKSSLKKTIFQDALRRT 801 Query: 542 QYSPQSWIEF-------AMYQTS 557 Q + +E A Y+TS Sbjct: 802 QNDHRVLLEIGVSFYAEAQYETS 824 Score = 61.1 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 90/588 (15%), Positives = 180/588 (30%), Gaps = 91/588 (15%) Query: 2 DTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEE-----LREYQRRKRTEYEG 56 D+L P VD + E ++ + + + ++ L + ++ + T+ Sbjct: 150 DSLIPGNVDLNKLTE-------EREKLLQSQIDENLAQLTKNASNPIQVNKPNAATDALS 202 Query: 57 YLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCIN 116 YLK D + A E D+++ R+I + D + WI E K + + Sbjct: 203 YLKDLENDRVNSLSDATLE----DLQKMRTILKSYRKADPTNPQGWIASARLEEKARKFS 258 Query: 117 HARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVN-AWNSFVDF 175 A+ ++ PR +W + + + ES +V ++L + P W +D Sbjct: 259 VAKKIIENGCQECPRSSDIWLENIRLHES--DVHYCKTLVATAINFNPTSPLLWFKAIDL 316 Query: 176 EIRQKNWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNL 235 E N R + W V FE + + A + Sbjct: 317 E--STTVNKYRVVRKALQEIPRDEGLWKLAVSFE---ADKAQVIKMLEKATQFIP----- 366 Query: 236 QIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDIN 295 M++ + + A+ + E W + LL+ E+ DI Sbjct: 367 ---QSMDLLTAYTNLQSYHNAKMTLNSFRKILPQEPEIWIISTLLE------ERNNPDIP 417 Query: 296 SIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAIVDSRPKELS 355 +++ +S ++ E + W +A+ D+ L+ Sbjct: 418 -VDKLVSLLKEGLLELSKNGYKATLSAWLKRA----------------EALNDAPNSNLT 460 Query: 356 KNVQWKRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLI 415 I W+R E EL N I + +PH + L Sbjct: 461 CQAIVYA-ILEWLRESGEYESELNNVD--------QILEKMPHSKVQIA--------VLK 503 Query: 416 RHDDVPKARKILGKAIGLCPKA-----KTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSD 470 + +L + + ++ + + EL + K D +R + Sbjct: 504 KLIQWDPCDTVLWSRLKMATESYHKIEELLAFFQELLFQTKNSDDIRANMRE------KS 557 Query: 471 LQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKE-----AKIVLLQKYITFETESQ 525 + Y E R + +D+ DF KI LL + + + Sbjct: 558 PGLLMMYVS-EYWKAQKGDTRQTLVL-IDQIIDFAPHNLDLRFFKIKLLGRSLQLDELRD 615 Query: 526 EFEKARKLYR-RYLELNQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQS 572 F++ + + ++ F YQ + L+ L+S Sbjct: 616 FFQQTFSSLEDFKISGTERLYYKYVNFLRYQDLNEEAIKFLNERCLKS 663 Score = 56.1 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 51/306 (16%), Positives = 99/306 (32%), Gaps = 13/306 (4%) Query: 288 EKQFGDINSIEETISYKRKMEYETILSNNAYDYDTWW-----LYLDLISESFPKQIMQTF 342 E ++ DI + ++ + L+ Y L E Q Sbjct: 116 ESEWMDIPDATDFTRRNKRNRIQEQLNRKTYAAPDSLIPGNVDLNKLTEEREKLLQSQID 175 Query: 343 EKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQ----RLIDDIIPH 398 E ++ V + Y+ +E + NSL + L R I Sbjct: 176 ENLAQLTKNASNPIQVNKPNAATDALSYLKDLENDRVNSLSDATLEDLQKMRTILKSYRK 235 Query: 399 KHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRK 458 T + W+ A+ + A+KI+ CP++ + + + + Sbjct: 236 ADPTNPQGWIASARLEEKARKFSVAKKIIENGCQECPRSSDIW-LENIRLHESDVHYCKT 294 Query: 459 IYEKFIEFQPSDLQIWSQYGELEENLGDWDRV--RGIYTIALDENSDFLTKEAKIVLLQK 516 + I F P+ +W + +LE + RV + + I DE L + Q Sbjct: 295 LVATAINFNPTSPLLWFKAIDLESTTVNKYRVVRKALQEIPRDEGLWKLAVSFEADKAQV 354 Query: 517 YITFETESQEFEKARKLYRRYLELNQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVD 576 E +Q ++ L Y L Y + + ++ P E ++ ++ L E + Sbjct: 355 IKMLEKATQFIPQSMDLLTAYTNLQSYH-NAKMTLNSFRKILPQEPEIWIISTLLEERNN 413 Query: 577 EDIEFE 582 DI + Sbjct: 414 PDIPVD 419 >2OOE-A nrPDB Length = 530 Score = 70.4 bits (170), Expect = 3e-12, Method: Composition-based stats. Identities = 78/491 (15%), Positives = 161/491 (32%), Gaps = 78/491 (15%) Query: 89 ERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNN 148 E+ L + + W + E + + I+ AR R ++ P + W Y+ E N Sbjct: 3 EKKLEENPYDLDAW-SILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKN 61 Query: 149 VEIVRSLYTKWCSLEPGVNAWNSFVDF--EIRQKNWNGVREIYSKYVMAHPQM------- 199 + V L+ + ++ W ++ + E + K + ++ Y A ++ Sbjct: 62 YDKVEKLFQRCLMKVLHIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSY 121 Query: 200 QTWLKWVRF---------ENRHGNTEFTRSVYSLA-IDTVANLQNLQIWSDMEVAKLVNS 249 Q W+ ++ F + R VY ++ + N++ L + + Sbjct: 122 QIWVDYINFLKGVEAVGSYAENQRITAVRRVYQRGCVNPMINIEQLWRDYNKYEEGINIH 181 Query: 250 FAH--WEAAQQEYERSS-------ALYQIAIEKWPS-----------NQLLKAGLLDFEK 289 A E ++Y + + + PS + + +EK Sbjct: 182 LAKKMIEDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVDMWKKYIQWEK 241 Query: 290 QFGDINSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISES---------------F 334 + I+ + YE L + D W+ + +S F Sbjct: 242 SNPLRTEDQTLITKRVMFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLF 301 Query: 335 PKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQR--LI 392 + +E+AI K+ + L+ Y Y E ++ + ++ R I Sbjct: 302 SDEAANIYERAISTL----------LKKNMLLYFAYADYEESRMKYEKV-HSIYNRLLAI 350 Query: 393 DDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKLKE 452 +DI P +++ Y KF R + + R I KA L Sbjct: 351 EDIDPTL------VYIQYMKFARRAEGIKSGRMIFKKAREDARTRHHVYVTAALMEYYCS 404 Query: 453 FDR--VRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAK 510 D+ KI+E ++ + Y + +L + + R ++ L S L E Sbjct: 405 KDKSVAFKIFELGLKKYGDIPEYVLAYIDYLSHLNEDNNTRVLFERVLTSGS--LPPEKS 462 Query: 511 IVLLQKYITFE 521 + +++ FE Sbjct: 463 GEIWARFLAFE 473 Score = 49.6 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 38/218 (17%), Positives = 79/218 (36%), Gaps = 12/218 (5%) Query: 441 KGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDE 500 + E + + D+ RK YE+ + PS + W Y E E ++D+V ++ L + Sbjct: 16 WSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLMK 75 Query: 501 NSDFLTKEAKIVLLQKYITFETESQ-----EFEKARKLYRRYLELNQYSPQSWIEFAMYQ 555 I L + Y+++ E++ EK + Y L+ S+ + Y Sbjct: 76 VL-------HIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQIWVDYI 128 Query: 556 TSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEEAIVFFKEKDDKQGRLSIL 615 + + A+ Q + + +++ + + + + + I Sbjct: 129 NFLKGVEAVGSYAENQRITAVRRVYQRGCVNPMINIEQLWRDYNKYEEGINIHLAKKMIE 188 Query: 616 EALKDYEETYGTELDQETVKKRFPKVIKKVRLQNGVEE 653 + +DY + ETV K + V QN +E Sbjct: 189 DRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNTPQE 226 Score = 47.2 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 54/359 (15%), Positives = 111/359 (30%), Gaps = 42/359 (11%) Query: 216 EFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWP 275 + R Y + + + E + Y++ L+Q + K Sbjct: 29 DKARKTYERLVAQFPSSGRFW-----------KLYIEAEIKAKNYDKVEKLFQRCLMKVL 77 Query: 276 SNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISESFP 335 L K L + G + S +E ++ + Y W Y++ + Sbjct: 78 HIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFAL-DKIGMEIMSYQIWVDYINFLKGVEA 136 Query: 336 KQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVE---LELENSLLEEELFQRLI 392 ++ R + LW Y Y E + L ++E+ + Sbjct: 137 VGSYAENQRITAVRRVYQRGCVNPMINIEQLWRDYNKYEEGINIHLAKKMIEDRSRDYMN 196 Query: 393 DDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKI--LGKAIGLCPKAKTFKGYIELEVKL 450 + ++ T K A + + +A+++ K I K+ + E + Sbjct: 197 ARRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVDMWKKYIQWE-KSNPLRT----EDQT 251 Query: 451 KEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENL-------GDWDRVR-------GIYTI 496 RV YE+ + IW + + E GD + + IY Sbjct: 252 LITKRVMFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYER 311 Query: 497 ALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELNQYSPQ-SWIEFAMY 554 A+ + ++L Y +E ++EK +Y R L + P +I++ + Sbjct: 312 AISTLL-----KKNMLLYFAYADYEESRMKYEKVHSIYNRLLAIEDIDPTLVYIQYMKF 365 >5MQ0-T nrPDB Length = 877 Score = 60.3 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 68/491 (13%), Positives = 159/491 (32%), Gaps = 84/491 (17%) Query: 57 YLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIP-------LWIRYIDAE 109 L+++ + W++ + +++ + E L +D + LW Y D Sbjct: 400 ALRQDSNLVETWMK--RVSLQKSAAEKCNVYSEAILKIDPRKVGTPGSFGRLWCSYGDLY 457 Query: 110 LKVKCINHARNLMNRAIST-LPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNA 168 + I+ AR L +++ P ++ L YL + + E V ++ +A Sbjct: 458 WRSNAISTARELWTQSLKVPYPYIEDLEEIYLNWADRELDKEGVERAFSIL------EDA 511 Query: 169 WNSFVDFEIRQKNWNGVREIYSKYVMAHPQMQTWLKWVRFENRH--GNTEFTRSVYSLAI 226 + + EI + + + ++ W K++ + + + + +++ Sbjct: 512 LHVPTNPEILLEKYKNGHRKIPAQTVLFNSLRIWSKYIDYLEAYCPKDANSSDKIFNKTK 571 Query: 227 DTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLD 286 + +L++ + FA + E S +Y+ I +P Sbjct: 572 MAYNTVIDLRLITPAMAEN----FALFLQNHYEVMESFQVYEKTIPLFP----------- 616 Query: 287 FEKQFGDINSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISESF-----PKQIMQT 341 I+ Y+ W YL++ + P+ I Sbjct: 617 --------PEIQ---------------------YELWIEYLEVATSHQLSSLSPEHIRFL 647 Query: 342 FEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVE----LELENSLLEEELFQRLIDDIIP 397 FEKA+ + + +++ Y + E L ++ + + Sbjct: 648 FEKALKNLCSNGIDCK-------TIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVST 700 Query: 398 HKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFK---GYIELEVKLKEFD 454 H ++W M R++ + I + P +K + + + E + E Sbjct: 701 HLESRL-QLWRMCISKAESTLGPSVTRELYQECIQILPNSKAVEFVIKFSDFESSIGETI 759 Query: 455 RVRKI--YEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIV 512 R R+I Y + + ++W + E GD + + + + S+ L A + Sbjct: 760 RAREILAYGAKLLPPSRNTELWDSFEIFELKHGDKETYKDMLKMKKVLESNMLIDSASVS 819 Query: 513 LLQKYITFETE 523 + I F Sbjct: 820 HEEGNINFVAA 830 Score = 55.3 bits (131), Expect = 9e-08, Method: Composition-based stats. Identities = 56/392 (14%), Positives = 128/392 (32%), Gaps = 55/392 (14%) Query: 200 QTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQE 259 + W + R R +++ ++ + ++ ++ ++A E ++ Sbjct: 448 RLWCSYGDLYWRSNAISTARELWTQSLK-------VPYPYIEDLEEIYLNWADRELDKEG 500 Query: 260 YERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAYD 319 ER+ ++ + A+ + ++L +E+ + RK+ +T+L Sbjct: 501 VERAFSILEDALHVPTNPEIL----------------LEKYKNGHRKIPAQTVLF---NS 541 Query: 320 YDTWWLYLDLISESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELE 379 W Y+D + PK I + + + + Sbjct: 542 LRIWSKYIDYLEAYCPKDANS--SDKIFNKTKMAYNTVIDLRLITPAMAENFALFLQNHY 599 Query: 380 NSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHD----DVPKARKILGKAIG-LC 434 + +++++ I P + ++W+ Y + H R + KA+ LC Sbjct: 600 EVMESFQVYEKTIPLFPPEIQY---ELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLC 656 Query: 435 PK----AKTFKGYIELEVKLKEF--------DRVRKIYEKFIEFQ-PSDLQIWSQYGELE 481 F Y E ++ R I + S LQ+W Sbjct: 657 SNGIDCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKA 716 Query: 482 ENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELN 541 E+ R +Y E L + + K+ FE+ E +AR++ +L Sbjct: 717 ESTLGPSVTRELY----QECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYGAKLL 772 Query: 542 QYSPQS--WIEFAMYQTSTPTEQQLLDLAKLQ 571 S + W F +++ ++ D+ K++ Sbjct: 773 PPSRNTELWDSFEIFELKHGDKETYKDMLKMK 804 Score = 50.7 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 55/431 (12%), Positives = 124/431 (28%), Gaps = 109/431 (25%) Query: 203 LKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYER 262 L ++ G + + ++ Q + ++ N + +E ++ Sbjct: 307 LSLAKYYISRGRLDSCGDLLKKSLQ--------QTLRYSDFDRIYNFYLLFEQECSQF-- 356 Query: 263 SSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAYDYDT 322 I + ++ EK + + E I+ + L ++ +T Sbjct: 357 ------ILGKLKENDSKFFNQKDWTEKLQAHMATFESLINLYDIYLNDVALRQDSNLVET 410 Query: 323 WWLYLDLISESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSL 382 W + L + K Sbjct: 411 WMKRVSLQKSAAEKC--------------------------------------------- 425 Query: 383 LEEELFQRLIDDIIPHKHFT---FSKIWLMYAKFLIRHDDVPKARKILGKAIGL------ 433 ++ I I P K T F ++W Y R + + AR++ +++ + Sbjct: 426 ---NVYSEAILKIDPRKVGTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLKVPYPYIE 482 Query: 434 -------------CPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPS---------DL 471 K + + LE L + EK+ L Sbjct: 483 DLEEIYLNWADRELDKEGVERAFSILEDALHVPTNPEILLEKYKNGHRKIPAQTVLFNSL 542 Query: 472 QIWSQYGE-LEENL-GDWDRVRGIYTI---ALDENSDFLTKEAKIVLLQKYITFETESQE 526 +IWS+Y + LE D + I+ A + D + + + F E Sbjct: 543 RIWSKYIDYLEAYCPKDANSSDKIFNKTKMAYNTVIDLRLITP--AMAENFALFLQNHYE 600 Query: 527 FEKARKLYRRYLELNQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITD- 585 ++ ++Y + + L Q + + +T + L+ L E++ E + + Sbjct: 601 VMESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQ-----LSSLSPEHIRFLFEKALKNL 655 Query: 586 -ENKLEARKVF 595 N ++ + +F Sbjct: 656 CSNGIDCKTIF 666 Score = 48.0 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 84/570 (14%), Positives = 186/570 (32%), Gaps = 62/570 (10%) Query: 53 EYEGYLKRNRLDMGQWIRYAQFEIEQHDM-RRARSIFERALLVDSSFIPLWIRYIDAELK 111 +E +++ ++ W RY ++ E+ ++ R ++ER + +W YI E Sbjct: 25 AFEYEIQKTPQNILTWKRYIEYWKEEGRTDKQIRWLYERFCSQFVTDTSIWEDYIRWEST 84 Query: 112 VKCINHARNLM--NRAISTLPRV-DKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNA 168 + + +R R + + R D++ YL E+ Y ++ Sbjct: 85 KEVVETSRIFWLFQRCLKSCVRDCDRICLSYL---------ELAIEQYDLAMIRHALASS 135 Query: 169 WNSFVDFEIRQKNWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDT 228 ++ E+ +K W+ V + + V+ Q+ + + V Sbjct: 136 LMK-MEREMHRKVWDPVIKFVEEKVLPLTQLDSTQEDEEESTDEAELINVLLVKGFTKGG 194 Query: 229 VANLQNLQ--IWSDMEVAKLVNSFAHWEAAQQEYERSSALY-------------QIAIEK 273 + + + D+ + ++ + Q+ E + L + + Sbjct: 195 FISEEISENGSRGDIWSSHILERYLKVAPQQKRNESLATLALTRDNITIKSVYEKYLPQD 254 Query: 274 WPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSN-NAYDYDTWW-----LYL 327 S + L + L FE F + S+E+ +YE + N D W L Sbjct: 255 ENSGKYLPSSELPFELNFNYLASLEKL---GLDNQYEEFMRQMNGIYPDKWLFLILSLAK 311 Query: 328 DLISESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEEL 387 IS +K++ + + + L+ + L + Sbjct: 312 YYISRGRLDSCGDLLKKSLQQTLRYSDFDRIY--NFYLLFEQECSQFILGKLKENDSKFF 369 Query: 388 FQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELE 447 Q+ + + TF + +Y I +DV L + L +T+ + L+ Sbjct: 370 NQKDWTEKLQAHMATFESLINLY---DIYLNDV-----ALRQDSNL---VETWMKRVSLQ 418 Query: 448 VKLKEFDRVRKIYEKFIEFQPSDLQ-------IWSQYGELEENLGDWDRVRGIYTIALDE 500 E V E ++ P + +W YG+L R ++T +L Sbjct: 419 KSAAEKCNVYS--EAILKIDPRKVGTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLKV 476 Query: 501 NSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELNQYSPQSWIEFAMYQTSTPT 560 ++ +I L + E + + E+A + L + ++ P Sbjct: 477 PYPYIEDLEEIYL--NWADRELDKEGVERAFSILEDALHVPTNPEILLEKYKNGHRKIPA 534 Query: 561 EQQLLDLAKLQSENVDEDIEFEITDENKLE 590 + L + ++ S+ +D + D N + Sbjct: 535 QTVLFNSLRIWSKYIDYLEAYCPKDANSSD 564 Score = 31.1 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 26/119 (21%), Positives = 44/119 (36%), Gaps = 16/119 (13%) Query: 8 AVDTHVSAE-QILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKRNRLDMG 66 +V TH+ + Q+ R K + G + L E ++ K E+ Sbjct: 697 SVSTHLESRLQLWRMCISKAESTLGPSVTRELYQECIQILPNSKAVEFV----------- 745 Query: 67 QWIRYAQFEIEQHDMRRARSIFE--RALLVDSSFIPLWIRYIDAELKVKCINHARNLMN 123 I+++ FE + RAR I LL S LW + ELK ++++ Sbjct: 746 --IKFSDFESSIGETIRAREILAYGAKLLPPSRNTELWDSFEIFELKHGDKETYKDMLK 802 >6B85-J nrPDB Length = 223 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 28/94 (29%), Positives = 44/94 (46%), Gaps = 1/94 (1%) Query: 407 WLMYAKFLIRHDDVPKARKILGKAIGLCP-KAKTFKGYIELEVKLKEFDRVRKIYEKFIE 465 WL+ L + + +A + KAI L P A +K ++ KL D + Y+K IE Sbjct: 118 WLLLGSVLEKLKRLDEAAEAYKKAIELKPNDASAWKELGKVLEKLGRLDEAAEAYKKAIE 177 Query: 466 FQPSDLQIWSQYGELEENLGDWDRVRGIYTIALD 499 P D + W + G++ E LG D Y A++ Sbjct: 178 LDPEDAEAWKELGKVLEKLGRLDEAAEAYKKAIE 211 Score = 35.3 bits (79), Expect = 0.082, Method: Composition-based stats. Identities = 23/111 (20%), Positives = 41/111 (36%), Gaps = 1/111 (0%) Query: 88 FERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLN 147 +++A+ +D + W+ K+K ++ A +AI P W + V E L Sbjct: 104 YKKAIELDPNDALAWLLLGSVLEKLKRLDEAAEAYKKAIELKPNDASAWKELGKVLEKLG 163 Query: 148 NVEIVRSLYTKWCSLEP-GVNAWNSFVDFEIRQKNWNGVREIYSKYVMAHP 197 ++ Y K L+P AW + + E Y K + P Sbjct: 164 RLDEAAEAYKKAIELDPEDAEAWKELGKVLEKLGRLDEAAEAYKKAIELDP 214 Score = 33.0 bits (73), Expect = 0.42, Method: Composition-based stats. Identities = 15/92 (16%), Positives = 32/92 (34%), Gaps = 1/92 (1%) Query: 40 LEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFI 99 LE+L+ Y+ ++ D W + + + A +++A+ +D Sbjct: 125 LEKLKRLDEAA-EAYKKAIELKPNDASAWKELGKVLEKLGRLDEAAEAYKKAIELDPEDA 183 Query: 100 PLWIRYIDAELKVKCINHARNLMNRAISTLPR 131 W K+ ++ A +AI P Sbjct: 184 EAWKELGKVLEKLGRLDEAAEAYKKAIELDPN 215 Score = 32.2 bits (71), Expect = 0.68, Method: Composition-based stats. Identities = 23/125 (18%), Positives = 46/125 (36%), Gaps = 6/125 (4%) Query: 456 VRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQ 515 + Y+K IE P+D W G + E L D Y A++ + + + Sbjct: 100 AAEAYKKAIELDPNDALAWLLLGSVLEKLKRLDEAAEAYKKAIELKPNDASA------WK 153 Query: 516 KYITFETESQEFEKARKLYRRYLELNQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENV 575 + + ++A + Y++ +EL+ ++W E + + K E Sbjct: 154 ELGKVLEKLGRLDEAAEAYKKAIELDPEDAEAWKELGKVLEKLGRLDEAAEAYKKAIELD 213 Query: 576 DEDIE 580 D+E Sbjct: 214 PNDLE 218 >5WLC-LP nrPDB Length = 440 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 25/155 (16%), Positives = 50/155 (32%), Gaps = 14/155 (9%) Query: 38 LDLEELREYQRRKRTEYEGYLKRNR-LDMGQWIRYAQFEIEQHD--------MRRARSIF 88 D E + +Y Y+ ++ + R + + +R I+ Sbjct: 37 TDFEHRLNSRGSSINDYIKYINYESNVNKLRAKRCKRILQVKKTNSLSDWSIQQRIGFIY 96 Query: 89 ERALLVDS---SFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVE-E 144 +R F +++ Y+ A N+ N+ + P +W E E Sbjct: 97 QRGTNKFPQDLKFWAMYLNYMKARGNQTSYKKIHNIYNQLLKLHPTNVDIWISCAKYEYE 156 Query: 145 SLNNVEIVRSLYTKWCSLEPGV-NAWNSFVDFEIR 178 N + R+++ P V W +V FE+ Sbjct: 157 VHANFKSCRNIFQNGLRFNPDVPKLWYEYVKFELN 191 Score = 46.9 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 27/135 (20%), Positives = 51/135 (37%), Gaps = 10/135 (7%) Query: 54 YEGYLKRNRLDMGQWIRYAQFEIEQHDMR---RARSIFERALLVDSSFIPLWIRYIDAEL 110 Y+ + D+ W Y + + + + +I+ + L + + + +WI E Sbjct: 96 YQRGTNKFPQDLKFWAMYLNYMKARGNQTSYKKIHNIYNQLLKLHPTNVDIWISCAKYEY 155 Query: 111 KVKC-INHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAW 169 +V RN+ + P V KLWY+Y+ E + I R + +N Sbjct: 156 EVHANFKSCRNIFQNGLRFNPDVPKLWYEYVKFELNFITKLINRR------KVMGLINER 209 Query: 170 NSFVDFEIRQKNWNG 184 +D + QKN Sbjct: 210 EQELDMQNEQKNNQA 224 Score = 46.5 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 38/225 (16%), Positives = 82/225 (36%), Gaps = 14/225 (6%) Query: 369 RYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYA----KFLIRHDDVPKAR 424 RY + + L+E+ LF + +I K F ++ + Sbjct: 5 RYYLEQCIPEMDDLVEKGLFTKNEVSLIMKKRTDFEHRLNSRGSSINDYIKYINYESNVN 64 Query: 425 KILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENL 484 K+ K + K + ++ R+ IY++ P DL+ W+ Y + Sbjct: 65 KLRAKRCKRILQVKKTNSLSDWSIQQ----RIGFIYQRGTNKFPQDLKFWAMYLNYMKAR 120 Query: 485 GDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETE-SQEFEKARKLYRRYLELNQY 543 G+ + I+ I N + + +E E F+ R +++ L N Sbjct: 121 GNQTSYKKIHNIY---NQLLKLHPTNVDIWISCAKYEYEVHANFKSCRNIFQNGLRFNPD 177 Query: 544 SPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENK 588 P+ W E+ ++ + +L++ K+ + + E ++ +E K Sbjct: 178 VPKLWYEYVKFELN--FITKLINRRKVMGLINEREQELDMQNEQK 220 Score = 31.1 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 33/205 (16%), Positives = 67/205 (32%), Gaps = 21/205 (10%) Query: 216 EFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWP 275 TR I + +L +++ EV+ ++ +E S Y I Sbjct: 2 SKTRYYLEQCIPEMDDLVEKGLFTKNEVSLIMKKRTDFEHRLNSRGSSINDYIKYINYES 61 Query: 276 SNQLLKAGLLDFEKQFGDINSIEETISYKRK-MEYETILSNNAYDYDTWWLYLDLI---- 330 + L+A Q NS+ + +R Y+ + D W +YL+ + Sbjct: 62 NVNKLRAKRCKRILQVKKTNSLSDWSIQQRIGFIYQRGTNKFPQDLKFWAMYLNYMKARG 121 Query: 331 SESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQR 390 +++ K+I + + + + +W+ Y N +FQ Sbjct: 122 NQTSYKKIHNIYNQLLKLHPTN-----------VDIWISCAKYEYEVHANFKSCRNIFQN 170 Query: 391 LIDDIIPHKHFTFSKIWLMYAKFLI 415 + + K+W Y KF + Sbjct: 171 GL-----RFNPDVPKLWYEYVKFEL 190 >1W3B-A nrPDB Length = 388 Score = 45.3 bits (105), Expect = 9e-05, Method: Composition-based stats. Identities = 40/286 (13%), Positives = 85/286 (29%), Gaps = 35/286 (12%) Query: 47 QRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYI 106 Y L+ N + A++ + +A+ +F W Sbjct: 117 MEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAW---- 172 Query: 107 DAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWC------ 160 + C+ +A+ + AI + L +L +L NV ++ + Sbjct: 173 ---SNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRA 229 Query: 161 -SLEPGVNAWNSFVD-FEIRQKNWNGVREIYSKYVMAHPQM-QTWLKWVRFENRHGNTEF 217 SL P + + Q + + Y + + P + G+ Sbjct: 230 LSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAE 289 Query: 218 TRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSN 277 Y+ A+ + +N+ A+ + Q E + LY+ A+E +P Sbjct: 290 AEDCYNTALRLCPTHAD-----------SLNNLANIKREQGNIEEAVRLYRKALEVFPEF 338 Query: 278 QLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAYDYDTW 323 + L +Q G + M Y+ + + D + Sbjct: 339 AAAHSNLASVLQQQGKLQEA--------LMHYKEAIRISPTFADAY 376 Score = 43.4 bits (100), Expect = 4e-04, Method: Composition-based stats. Identities = 32/201 (15%), Positives = 65/201 (32%), Gaps = 9/201 (4%) Query: 38 LDLEELREYQRRKRTE---YEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLV 94 DL L + R Y ++ W Q ++ A FE+A+ + Sbjct: 139 SDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTL 198 Query: 95 DSSFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRS 154 D +F+ +I + + + + A RA+S P + V +++ Sbjct: 199 DPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAID 258 Query: 155 LYTKWCSLEPGVNAWNSFVDFEIRQKN---WNGVREIYSKYVMAHPQMQTWL-KWVRFEN 210 Y + L+P +++ + K + Y+ + P L + Sbjct: 259 TYRRAIELQPHFP--DAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKR 316 Query: 211 RHGNTEFTRSVYSLAIDTVAN 231 GN E +Y A++ Sbjct: 317 EQGNIEEAVRLYRKALEVFPE 337 >4EBA-A nrPDB Length = 645 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 83/605 (13%), Positives = 194/605 (32%), Gaps = 73/605 (12%) Query: 55 EGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAE---LK 111 ++ D+ +++ + + ++ F++ +W + E ++ Sbjct: 22 NDMIEEQPTDIFLYVKLLKHHVSLKQWKQVYETFDKLHDRFPLMANIWCMRLSLEFDKME 81 Query: 112 VKCINHARNLMNRAISTLPRVD--KLWYKYLIV------------EESLNNVEIVRSLYT 157 ++ R +S + LW Y+ E ++ + + Sbjct: 82 ELDAAVIEPVLARCLSKELGNNDLSLWLSYITYVRKKNDIITGGEEARNIVIQAFQVVVD 141 Query: 158 KWCSLEPG-VNAWNSFVDFEIRQKNWNG---------VREIYSKYVMAHPQ--MQTWLKW 205 K EP + WN ++ F K N +R++Y + W ++ Sbjct: 142 KCAIFEPKSIQFWNEYLHFLEHWKPVNKFEEQQRVQYIRKLYKTLLCQPMDCLESMWQRY 201 Query: 206 VRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSA 265 ++E R + L+ + Q W + + K + Q Sbjct: 202 TQWEQDVNQLTARRHIGELSAQYMNARSLYQDW--LNITKGLKRNLPITLNQATESNLPK 259 Query: 266 LYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAYDYDTWW- 324 + +++ D + + D + + Y + + + W+ Sbjct: 260 PNEYDVQQLLIWLEWIRWESDNKLELSD-----DLHKARMTYVYMQAAQHVCFAPEIWFN 314 Query: 325 ----------------LYLDLISESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWM 368 YL L + P + + S ++ N + + Sbjct: 315 MANYQGEKNTDSTVITKYLKLGQQCIPNSAV------LAFSLSEQYELNTKIPEIETTIL 368 Query: 369 RYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILG 428 I + L+L + ++ + I+ + + ++ +Y + R + +RKI G Sbjct: 369 SCIDRIHLDLAALMEDDPTNESAINQLKSKLTY----VYCVYMNTMKRIQGLAASRKIFG 424 Query: 429 KAIGL----CPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENL 484 K L P YIE + K+ E +++ +D + ++Y + + Sbjct: 425 KCRRLKKLVTPDIYLENAYIEYHISKDTKTAC-KVLELGLKYFATDGEYINKYLDFLIYV 483 Query: 485 GDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELNQYS 544 + +V+ ++ ++D+ SD ++ QK I FE++ R L +R+ E Sbjct: 484 NEESQVKSLFESSIDKISD---SHLLKMIFQKVIFFESKVGSLNSVRTLEKRFFEKFPEV 540 Query: 545 PQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFE--EAIVFF 602 + Y+ Q L+L + + + E I + N + E +A F Sbjct: 541 NKLEEFTNKYKVLDVNYLQRLELDYMVRDVMPEAIALDRGSNNLKRTMREEEDGQAFKKF 600 Query: 603 KEKDD 607 K +D Sbjct: 601 KANED 605 >3JB9-r nrPDB Length = 790 Score = 38.8 bits (88), Expect = 0.009, Method: Composition-based stats. Identities = 20/91 (21%), Positives = 33/91 (36%), Gaps = 8/91 (8%) Query: 47 QRRKRTEYEGYLKRNRLDMGQ--WIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIR 104 R R +E L+ + + ++ YA FE + +R+ SI E+A + L I Sbjct: 569 MERTRDLFEQALEGCPPEFSKSIYLLYADFEEKFGKAKRSISILEKAADKVKTADRLAI- 627 Query: 105 YIDAELKVKCINHARNLMNRAISTLPRVDKL 135 V + A N A T+ Sbjct: 628 -----YNVLLVKVALNYGVLATRTVYEKAIE 653 Score = 37.2 bits (84), Expect = 0.023, Method: Composition-based stats. Identities = 24/161 (14%), Positives = 57/161 (35%), Gaps = 11/161 (6%) Query: 384 EEELFQRLIDDII--PHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFK 441 +L+ R+ + I P ++ + A F + + + Sbjct: 499 TRKLYDRVFELKIATPQVVVNYANLLEENAYFEDSFKIYERGVALFSYPVAFELWNLYLT 558 Query: 442 GYIELEVKLKEFDRVRKIYEKFIEFQPSDLQ--IWSQYGELEENLGDWDRVRGIYTIALD 499 +++ + +R R ++E+ +E P + I+ Y + EE G R I A D Sbjct: 559 KFVK-RYQGTHMERTRDLFEQALEGCPPEFSKSIYLLYADFEEKFGKAKRSISILEKAAD 617 Query: 500 ENS-DFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLE 539 + ++L++ + + + R +Y + +E Sbjct: 618 KVKTADRLAIYNVLLVKVALNYGVLA-----TRTVYEKAIE 653 Score = 34.1 bits (76), Expect = 0.21, Method: Composition-based stats. Identities = 28/154 (18%), Positives = 53/154 (34%), Gaps = 32/154 (20%) Query: 490 VRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELNQYSPQSWI 549 R +Y D + ++V+ Y E+ FE + K+Y R + L Y + Sbjct: 499 TRKLY----DRVFELKIATPQVVV--NYANLLEENAYFEDSFKIYERGVALFSYP----V 548 Query: 550 EFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEEAIVFFKEKDDKQ 609 F ++ L K +E R +FE+A + + Sbjct: 549 AFELWNLY---------LTKFVKRYQGTHME---------RTRDLFEQA---LEGCPPEF 587 Query: 610 GRLSILEALKDYEETYGTELDQETVKKRFPKVIK 643 + SI D+EE +G ++ ++ +K Sbjct: 588 SK-SIYLLYADFEEKFGKAKRSISILEKAADKVK 620 Score = 32.6 bits (72), Expect = 0.59, Method: Composition-based stats. Identities = 22/110 (20%), Positives = 41/110 (37%), Gaps = 13/110 (11%) Query: 244 AKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETISY 303 A L+ A++E + + YER AL+ + +L L F + + T Sbjct: 521 ANLLEENAYFEDSFKIYERGVALFSYPVAF----ELWNLYLTKF------VKRYQGTHME 570 Query: 304 KRKMEYETILSNNA--YDYDTWWLYLDLISE-SFPKQIMQTFEKAIVDSR 350 + + +E L + + LY D + K+ + EKA + Sbjct: 571 RTRDLFEQALEGCPPEFSKSIYLLYADFEEKFGKAKRSISILEKAADKVK 620 Score = 30.7 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 20/96 (20%), Positives = 32/96 (33%), Gaps = 7/96 (7%) Query: 71 YAQFEIEQHDMRRARSIFER--ALLVDSSFIPLWIRYIDA---ELKVKCINHARNLMNRA 125 YA E + I+ER AL LW Y+ + + R+L +A Sbjct: 520 YANLLEENAYFEDSFKIYERGVALFSYPVAFELWNLYLTKFVKRYQGTHMERTRDLFEQA 579 Query: 126 ISTLP--RVDKLWYKYLIVEESLNNVEIVRSLYTKW 159 + P ++ Y EE + S+ K Sbjct: 580 LEGCPPEFSKSIYLLYADFEEKFGKAKRSISILEKA 615 Score = 30.7 bits (67), Expect = 2.1, Method: Composition-based stats. Identities = 23/134 (17%), Positives = 48/134 (35%), Gaps = 9/134 (6%) Query: 119 RNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTK---WCSLEPGVNAWNSFVDF 175 R L +R ++ Y + E E +Y + S WN ++ Sbjct: 500 RKLYDRVFELKIATPQVVVNYANLLEENAYFEDSFKIYERGVALFSYPVAFELWNLYLTK 559 Query: 176 EIRQKN---WNGVREIYSKYVMAHP---QMQTWLKWVRFENRHGNTEFTRSVYSLAIDTV 229 +++ R+++ + + P +L + FE + G + + S+ A D V Sbjct: 560 FVKRYQGTHMERTRDLFEQALEGCPPEFSKSIYLLYADFEEKFGKAKRSISILEKAADKV 619 Query: 230 ANLQNLQIWSDMEV 243 L I++ + V Sbjct: 620 KTADRLAIYNVLLV 633 >5G05-C nrPDB Length = 597 Score = 37.6 bits (85), Expect = 0.019, Method: Composition-based stats. Identities = 31/203 (15%), Positives = 67/203 (33%), Gaps = 4/203 (1%) Query: 82 RRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLI 141 +A F+RAL ++ ++ W +++K + A AI R + WY Sbjct: 348 EKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQ 407 Query: 142 VEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVD--FEIRQKNWNGVREIYSKYVMAHPQM 199 E L Y + L P + + +E + + + Y + + Sbjct: 408 TYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEK 467 Query: 200 QTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQE 259 +K + + +E Y I + + +I +E + A + + Sbjct: 468 MALVKLAKLHEQLTESEQAAQCYIKYIQDIYSCG--EIVEHLEESTAFRYLAQYYFKCKL 525 Query: 260 YERSSALYQIAIEKWPSNQLLKA 282 ++ +S Q + + KA Sbjct: 526 WDEASTCAQKCCAFNDTREEGKA 548 >2GW1-A nrPDB Length = 514 Score = 36.8 bits (83), Expect = 0.030, Method: Composition-based stats. Identities = 49/263 (18%), Positives = 95/263 (36%), Gaps = 31/263 (11%) Query: 361 KRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDV 420 K+ I L+ R Y+ + L + + D S ++ + + Sbjct: 261 KKAIELFPRVNSYIYMALIMADRNDSTEYYNYFDKALKLDSNNSSVYYHRGQMNFILQNY 320 Query: 421 PKARKILGKAIGLCPKAK-TFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGE 479 +A K KA L P+ + L + +FD ++ + P ++ + + E Sbjct: 321 DQAGKDFDKAKELDPENIFPYIQLACLAYRENKFDDCETLFSEAKRKFPEAPEVPNFFAE 380 Query: 480 LEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETES---QEFEKARKLYRR 536 + + D+D+ Y +A++ + I L T T + + F +A L + Sbjct: 381 ILTDKNDFDKALKQYDLAIELENKLDGIYVGIAPLVGKATLLTRNPTVENFIEATNLLEK 440 Query: 537 YLELNQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFE 596 +L+ S Q+ I A KLQ E++DE I +FE Sbjct: 441 ASKLDPRSEQAKIGLAQ--------------MKLQQEDIDEAI-------------TLFE 473 Query: 597 EAIVFFKEKDDKQGRLSILEALK 619 E+ + ++K ++ EA K Sbjct: 474 ESADLARTMEEKLQAITFAEAAK 496 >5UDI-A nrPDB Length = 479 Score = 34.1 bits (76), Expect = 0.18, Method: Composition-based stats. Identities = 48/293 (16%), Positives = 96/293 (32%), Gaps = 33/293 (11%) Query: 377 ELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIG---- 432 E EN + EE Q + ++ +F + ++ + + K I K Sbjct: 78 EAENLMQEEHDNQANVRSLVTWGNFAW--MYYHMGRLAEAQTYLDKVENICKKLSNPFRY 135 Query: 433 --LCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRV 490 CP+ +G+ L+ K ++R + +EK +E P + + + Y L + Sbjct: 136 RMECPEIDCEEGWALLKCGGKNYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLA 195 Query: 491 ----RGIYTIALDENSDFLTKEAKIVLLQKYITFETESQE-------------------F 527 + + L + I +L + + F Sbjct: 196 TKNHKPFSLLPLRQAVRLNPDNGYIKVLLALKLQDEGQEAEGEKYIEEALANMSSQTYVF 255 Query: 528 EKARKLYRRYLELNQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDEN 587 A K YRR +++ TS Q+ K Q + E + + +N Sbjct: 256 RYAAKFYRRKGSVDKALELLKKALQETPTSVLLHHQIGLCYKAQMIQIKEATKGQPRGQN 315 Query: 588 KLEARKVFEEAIVFFKEKDDKQGRLSI--LEALKDYEETYGTELDQETVKKRF 638 + + K+ AI F+ +K+ + L+ + Y E +E +K Sbjct: 316 REKLDKMIRSAIFHFESAVEKKPTFEVAHLDLARMYIEAGNHRKAEENFQKLL 368 >6MFV-A nrPDB Length = 653 Score = 33.4 bits (74), Expect = 0.30, Method: Composition-based stats. Identities = 67/409 (16%), Positives = 148/409 (36%), Gaps = 57/409 (13%) Query: 230 ANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEK 289 + ++ S+ E ++ ++ + ++ AI K S++L++ + K Sbjct: 284 MVREFVREVSNQEEKEVYLRHVNFLLKSKTPINFLRAFKYAI-KVGSSELIRNLVELRVK 342 Query: 290 QFGDINSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAIVDS 349 +F I ++ Y+R + + +N Y I + + FEKAI Sbjct: 343 EFYRII-VDFPRMYQRLLM---EVEDNPYAK---------IEIAIIEVQRGLFEKAIKLL 389 Query: 350 RPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLM 409 + E + +K IY W+ +ELEN E + + +I+ + ++ W Sbjct: 390 KEAEPYVDEFFKCEIYSWLADAY---MELENLEKAER-YLKKTKEIVEKINDMYA--WFS 443 Query: 410 YAKFLIRHDDVPK-ARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQP 468 Y +++ + +R+ L A+ +E+ K+ + ++ E + Sbjct: 444 YYAEKTKYEYYKENSREALKSALKE----------LEIIRKIGDPEK-----EGLVLLHV 488 Query: 469 SDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFE 528 D+ + G E+ + + + + + ++ + +E S+ E Sbjct: 489 GDI--YLHMGNYEKGISYYQEALKMAKAYGIKFLEHISYMELAKGYYQLKLYEKASEYSE 546 Query: 529 KARKL------YRRYLELNQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFE 582 KA YRR + Y S+I + + ++++ +A + Sbjct: 547 KAANYFLMIRNYRRATDAMAYGSVSYIATKNLEKAEKFAKEMIRIA-------------Q 593 Query: 583 ITDENKLEARKVFEEAIVFFKEKDDKQGRLSILEALKDYEETYGTELDQ 631 TD A +F A+ F K D ++ LK+Y + LD+ Sbjct: 594 STDYPLAWAGYIFLAAVDFLKGDDWREDYNLGKAHLKEYPWLFEAVLDE 642 >2OND-A nrPDB Length = 308 Score = 33.4 bits (74), Expect = 0.31, Method: Composition-based stats. Identities = 32/241 (13%), Positives = 73/241 (30%), Gaps = 34/241 (14%) Query: 189 YSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVN 248 Y + + N ++ ++Y AI T+ L L Sbjct: 54 YEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNML----------LYF 103 Query: 249 SFAHWEAAQQEYERSSALYQIAIEKWP-SNQLLKAGLLDFEKQFGDINSIEETISYKRKM 307 ++A +E ++ +YE+ ++Y + L+ + F E S + Sbjct: 104 AYADYEESRMKYEKVHSIYNRLLAIEDIDPTLVYIQYMKFA------RRAEGIKSGRMIF 157 Query: 308 EYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLW 367 + + + ++ + FE + K Y+ + Sbjct: 158 KKAREDARTRHHVYVTAALMEYYCSKDKSVAFKIFELGL--------KKYGDIPEYVLAY 209 Query: 368 MRYICYVELELENSLLEEELFQRLID--DIIPHKHFTFSKIWLMYAKFLIRHDDVPKARK 425 + Y+ ++ LF+R++ + P K +IW + F D+ K Sbjct: 210 IDYLSHLN----EDNNTRVLFERVLTSGSLPPEKS---GEIWARFLAFESNIGDLASILK 262 Query: 426 I 426 + Sbjct: 263 V 263 Score = 29.5 bits (64), Expect = 4.7, Method: Composition-based stats. Identities = 16/88 (18%), Positives = 35/88 (39%), Gaps = 4/88 (4%) Query: 79 HDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAIST----LPRVDK 134 D A IFE L + YID + N+ R L R +++ + + Sbjct: 183 KDKSVAFKIFELGLKKYGDIPEYVLAYIDYLSHLNEDNNTRVLFERVLTSGSLPPEKSGE 242 Query: 135 LWYKYLIVEESLNNVEIVRSLYTKWCSL 162 +W ++L E ++ ++ + + + + Sbjct: 243 IWARFLAFESNIGDLASILKVEKRRFTA 270 >5LCW-S nrPDB Length = 342 Score = 33.4 bits (74), Expect = 0.34, Method: Composition-based stats. Identities = 42/263 (15%), Positives = 93/263 (35%), Gaps = 32/263 (12%) Query: 300 TISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAIVDSRPKELSKNVQ 359 KR EYE D W Y+ +++P+ ++ +++ + L + Sbjct: 55 LQQQKRAFEYEIRFYTGNDPLDVWDRYISWTEQNYPQGGKESNMSTLLERAVEALQGEKR 114 Query: 360 W---KRYIYLWMRY--ICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFL 414 + R++ LW++ +C L++ + L + + + ++ ++ +A+ Sbjct: 115 YYSDPRFLNLWLKLGRLCNEPLDMYSYLHNQGI------------GVSLAQFYISWAEEY 162 Query: 415 IRHDDVPKARKILGKAI--GLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQ 472 ++ KA I + I P + + + + ++ + E+ E S + Sbjct: 163 EARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARVSRQTLLALEKEEEEEVFESSVP 222 Query: 473 IWSQYGELEENLGDWDRVRGI----YTIALDENSDFLTKEAKIVLLQKYIT-FETESQEF 527 S EL+ R I A +N + + IT F+ + E Sbjct: 223 QRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEA 282 Query: 528 EKARKLYRRYLELNQYSPQSWIE 550 A EL++ + Q WI Sbjct: 283 STA--------ELSKPTVQPWIA 297 >4HOQ-A nrPDB Length = 482 Score = 33.0 bits (73), Expect = 0.46, Method: Composition-based stats. Identities = 44/238 (18%), Positives = 84/238 (35%), Gaps = 35/238 (14%) Query: 407 WLMYAKFLIRHDDVPKARKI---LGKAIGL----------CPKAKTFKGYIELEVKLKEF 453 W YA D + +A+K +G CP+ KG+ L+ K + Sbjct: 97 WGNYAWVYYHMDQLEEAQKYTGKIGNVCKKLSSPSNYKLECPETDCEKGWALLKFGGKYY 156 Query: 454 DRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYT-------IALDENSDFLT 506 + + +EK +E +P + + Y L D DR + + A+ N D Sbjct: 157 QKAKAAFEKALEVEPDNPEFNIGYAITVYRLDDSDREGSVKSFSLGPLRKAVTLNPDNSY 216 Query: 507 KEAKIVLLQKYITFETESQEFEK---------------ARKLYRRYLELNQYSPQSWIEF 551 + + L + + E E +++ + A K YRR N+ Sbjct: 217 IKVFLALKLQDVHAEAEGEKYIEEILDQISSQPYVLRYAAKFYRRKNSWNKALELLKKAL 276 Query: 552 AMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEEAIVFFKEKDDKQ 609 + TS+ Q+ + Q + + ++KL+ ++ AI FK ++ Sbjct: 277 EVTPTSSFLHHQMGLCYRAQMIQIKKATHNRPKGKDKLKVDELISSAIFHFKAAMERD 334 >5B16-A nrPDB Length = 986 Score = 32.2 bits (71), Expect = 0.67, Method: Composition-based stats. Identities = 19/83 (22%), Positives = 33/83 (39%), Gaps = 8/83 (9%) Query: 79 HDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYK 138 + A+ +F R L D +W+ Y L+++ N R L I T P + KL Sbjct: 668 GSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQEPNTDRQL----IETSPVLQKL--- 720 Query: 139 YLIVEESLNNVEIVRSLYTKWCS 161 EE++ + L + + Sbjct: 721 -TEFEEAIGVIFTHVRLLARAFT 742 >2PLJ-A nrPDB Length = 419 Score = 32.2 bits (71), Expect = 0.68, Method: Composition-based stats. Identities = 19/98 (19%), Positives = 33/98 (33%), Gaps = 5/98 (5%) Query: 5 EPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKRNRLD 64 E D + I RD + A G + +L EL +++ R + E ++ L Sbjct: 118 EGVPADLTIHTHPIKRDADIRDALAYGCNVFVVDNLNELEKFKAY-RDDVELLVR---LS 173 Query: 65 MGQWIRYAQFEIEQH-DMRRARSIFERALLVDSSFIPL 101 +A + +A I E A + L Sbjct: 174 FRNSEAFADLSKKFGCSPEQALVIIETAKEWNIRIKGL 211 >5ZYP-A nrPDB Length = 390 Score = 32.2 bits (71), Expect = 0.79, Method: Composition-based stats. Identities = 21/158 (13%), Positives = 50/158 (31%), Gaps = 16/158 (10%) Query: 170 NSFVDFEIRQKNWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTV 229 V ++ + ++ + V + + + WL HG T + +A+D Sbjct: 27 EELVGIDLETDLPDDPTDLKTLLVEENSEKEHWLTIALAYCNHGKTNEGIKLIEMALDVF 86 Query: 230 ANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEK 289 N S+ ++AH A+ + +L + F+ Sbjct: 87 QN-------SERASLHTFLTWAHLNLAKGQSLSVETKEHEL----TQAELNLKDAIGFDP 135 Query: 290 QF-GDINSIEETI----SYKRKMEYETILSNNAYDYDT 322 + G++ + E Y + +E + + + D Sbjct: 136 TWIGNMLATVELYYQRGHYDKALETSDLFVKSIHAEDH 173 >4HOU-A nrPDB Length = 273 Score = 31.8 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 35/204 (17%), Positives = 72/204 (35%), Gaps = 15/204 (7%) Query: 377 ELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIG---- 432 E EN + EE Q + ++ +F + ++ + + K I K Sbjct: 71 EAENLMQEEHDNQANVRSLVTWGNFAW--MYYHMGRLAEAQTYLDKVENICKKLSNPFRY 128 Query: 433 --LCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRV 490 CP+ +G+ L+ K ++R + +EK +E P + + + Y L + Sbjct: 129 RMECPEIDCEEGWALLKCGGKNYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLA 188 Query: 491 ----RGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELNQ--YS 544 + + L + I +L + + E QE E + + ++ Y Sbjct: 189 TKNHKPFSLLPLRQAVRLNPDNGYIKVLLA-LKLQDEGQEAEGEKYIEEALANMSSQTYV 247 Query: 545 PQSWIEFAMYQTSTPTEQQLLDLA 568 + +F + S +LL A Sbjct: 248 FRYAAKFYRRKGSVDKALELLKKA 271 >2JGU-A nrPDB Length = 775 Score = 31.5 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 14/60 (23%), Positives = 24/60 (40%), Gaps = 9/60 (15%) Query: 18 ILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIE 77 +LR Y++ + A + + EYQRR R Y G + + G W + + Sbjct: 357 LLRKAYERNEVAPNKPSEE--------EYQRRLRESYTGGFVKEP-EKGLWENIVYLDYK 407 >3ESL-A nrPDB Length = 202 Score = 30.3 bits (66), Expect = 3.0, Method: Composition-based stats. Identities = 29/165 (17%), Positives = 65/165 (39%), Gaps = 21/165 (12%) Query: 301 ISYKRKMEYETILSNNAYD----YDTWWL--YLDLISESFPKQIMQTFEKAIVDSRPKEL 354 I+Y++++ + ++ D Y W Y+++ SES + + T E+ ++ + E Sbjct: 13 IAYEQRLLNDLEDMDDPLDLFLDYMIWISTSYIEVDSESGQEVLRSTMERCLIYIQDMET 72 Query: 355 SKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKI-----WLM 409 +N I++W + E+ + +F + I + + FSK+ + + Sbjct: 73 YRNDPRFLKIWIWYINLFLSNNFHESENTFKYMFNKGIGTKLSLFYEEFSKLLENAQFFL 132 Query: 410 YAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKLKEFD 454 AK L+ R P + + E +L+E + Sbjct: 133 EAKVLLELGAENNCR----------PYNRLLRSLSNYEDRLREMN 167 >5VU6-A nrPDB Length = 774 Score = 30.3 bits (66), Expect = 3.1, Method: Composition-based stats. Identities = 14/60 (23%), Positives = 23/60 (38%), Gaps = 10/60 (16%) Query: 18 ILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIE 77 +LR Y++ + A D +EL R+R YEG + + G W + Sbjct: 357 LLRKAYERNELAPNKP-----DEKEL----ARRRQSYEGGYVKEP-ERGLWENIVYLDFR 406 >6JEB-A nrPDB Length = 469 Score = 29.9 bits (65), Expect = 3.8, Method: Composition-based stats. Identities = 13/83 (15%), Positives = 27/83 (32%) Query: 468 PSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEF 527 P ++W Y + L D ++ + ++ K + + E ++ Sbjct: 227 PQKPEVWKFYASVFNELKDIFPSGIVHLGGDEAPTELWEKCPLCREARTRAAMKDEQEQM 286 Query: 528 EKARKLYRRYLELNQYSPQSWIE 550 + L N +PQ W E Sbjct: 287 KAFFAKTAALLAKNGQTPQFWYE 309 >1F7U-A nrPDB Length = 607 Score = 29.1 bits (63), Expect = 7.2, Method: Composition-based stats. Identities = 20/111 (18%), Positives = 50/111 (45%), Gaps = 10/111 (9%) Query: 523 ESQEFEKARKLYRRYLELNQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFE 582 E KAR+ ++R + ++ + + W F + E+ + A+L + E + Sbjct: 241 EQSTNGKAREYFKRMEDGDEEALKIWKRFREFSI----EKYIDTYARLNIKYDVYSGESQ 296 Query: 583 ITDENKLEARKVFEEAIVFFKEKDDKQGRLSILEALKDYEETYGTELDQET 633 ++ E+ L+A +F+E + + + ++L L + + G + Q++ Sbjct: 297 VSKESMLKAIDLFKEKGLT------HEDKGAVLIDLTKFNKKLGKAIVQKS 341 >6GAZ-AO nrPDB Length = 239 Score = 28.8 bits (62), Expect = 8.7, Method: Composition-based stats. Identities = 22/132 (16%), Positives = 43/132 (32%), Gaps = 3/132 (2%) Query: 475 SQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLY 534 + +E L + L+ D + EA+IV L I E + + K + Sbjct: 96 LEMANQKEKLKIKKM--QLMNKVLENPEDTSSLEARIVALTVKIRNYEEHMQKHRKDKAH 153 Query: 535 RRYLELNQYSPQSWIEFAMYQTSTPTEQQLLDLA-KLQSENVDEDIEFEITDENKLEARK 593 +R+L ++ + ++ E+ +L + K + Sbjct: 154 KRFLLMSIDQRKKMLKNLRETNYAVFEKICKELGIEYTFPPPYHRKAHRRWVTKKALCTQ 213 Query: 594 VFEEAIVFFKEK 605 VF E K+K Sbjct: 214 VFREVQKLKKQK 225 >5O2N-A nrPDB Length = 616 Score = 28.4 bits (61), Expect = 9.8, Method: Composition-based stats. Identities = 24/142 (16%), Positives = 47/142 (33%), Gaps = 28/142 (19%) Query: 182 WNGVREIYSKYVMAHPQMQTWLKW-VRFENRHGNTEFTRSVYSLAIDT------------ 228 W+ + + S + TWL W R GNT+ +Y A T Sbjct: 294 WDELASVISHMPEKLQKSPTWLYWLARSRAATGNTQEAEKLYKQAAATGRNFYAVLAGEE 353 Query: 229 ----------VANLQNLQIWSDMEVAKLVNSFAHWEAAQ-----QEYERSSALYQIAIEK 273 V + + E + + ++ +Q + ++ A ++ A Sbjct: 354 LGRKIDTRNNVPDAGKNSVRRMAEDGAVKRALVLFQNSQSAGDAKMRRQAQAEWRFATRG 413 Query: 274 WPSNQLLKAGLLDFEKQFGDIN 295 + ++LL A F+ F D+ Sbjct: 414 FDEDKLLTAAQTAFDHGFYDMA 435 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.305 0.112 0.270 Lambda K H 0.267 0.0341 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 21,263,652 Number of Sequences: 36641 Number of extensions: 780955 Number of successful extensions: 3641 Number of sequences better than 10.0: 66 Number of HSP's better than 10.0 without gapping: 60 Number of HSP's successfully gapped in prelim test: 51 Number of HSP's that attempted gapping in prelim test: 2745 Number of HSP's gapped (non-prelim): 344 length of query: 687 length of database: 10,336,785 effective HSP length: 104 effective length of query: 583 effective length of database: 6,526,121 effective search space: 3804728543 effective search space used: 3804728543 T: 11 A: 40 X1: 16 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 62 (28.8 bits)