BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q11176 (611 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1NR0-A nrPDB 1244 0.0 1PI6-A nrPDB 249 2e-66 3DM0-A nrPDB 77 2e-14 2H9P-A nrPDB 72 1e-12 5M25-A nrPDB 71 2e-12 5WYJ-BC nrPDB 70 4e-12 6QX9-4B nrPDB 66 6e-11 6G51-g nrPDB 65 1e-10 5FL8-q nrPDB 63 3e-10 5GAN-H nrPDB 63 4e-10 6HHQ-h nrPDB 60 2e-09 4A11-B nrPDB 60 2e-09 6F3T-A nrPDB 60 3e-09 5NNZ-B nrPDB 60 3e-09 3FM0-A nrPDB 59 4e-09 3JAP-g nrPDB 59 5e-09 6MZM-G nrPDB 59 7e-09 4BH6-A nrPDB 58 1e-08 5G04-R nrPDB 58 1e-08 5A31-R nrPDB 58 1e-08 5MZH-A nrPDB 57 2e-08 4GGA-A nrPDB 57 2e-08 5LCW-Q nrPDB 57 2e-08 4N14-A nrPDB 57 2e-08 4V6W-Ag nrPDB 57 3e-08 1VYH-C nrPDB 57 3e-08 5WBU-D nrPDB 56 4e-08 6QX9-5O nrPDB 56 4e-08 3MKQ-A nrPDB 55 6e-08 4V8M-A7 nrPDB 55 7e-08 2YNP-A nrPDB 55 9e-08 5OQL-d nrPDB 55 9e-08 5WJC-A nrPDB 54 1e-07 5OPT-p nrPDB 54 2e-07 6HQA-B nrPDB 53 4e-07 5I2T-A nrPDB 53 4e-07 5WLC-LO nrPDB 52 6e-07 4BTS-AR nrPDB 52 1e-06 5WYK-BB nrPDB 50 2e-06 3C9C-A nrPDB 50 2e-06 6J6H-n nrPDB 50 3e-06 5Z56-q nrPDB 49 5e-06 6Q8F-A nrPDB 49 7e-06 3JB9-L nrPDB 48 1e-05 4V7E-Bg nrPDB 48 1e-05 4LG8-A nrPDB 48 1e-05 5Y1U-A nrPDB 47 3e-05 2HES-X nrPDB 47 3e-05 6GMH-W nrPDB 46 4e-05 4J0W-A nrPDB 46 4e-05 3CFV-B nrPDB 46 6e-05 5XYI-g nrPDB 46 6e-05 5OQL-J nrPDB 45 7e-05 5OV3-A nrPDB 45 8e-05 6N9G-C nrPDB 45 9e-05 3JB9-g nrPDB 45 1e-04 5WLC-LU nrPDB 44 2e-04 5MC6-j nrPDB 44 3e-04 5Y88-O nrPDB 44 3e-04 5K1B-B nrPDB 44 3e-04 6BX3-A nrPDB 43 3e-04 5NZU-C nrPDB 43 3e-04 5OQL-X nrPDB 43 4e-04 6EOJ-D nrPDB 43 5e-04 5FVM-C nrPDB 42 6e-04 4YCZ-A nrPDB 42 6e-04 2AQ5-A nrPDB 42 7e-04 5L9T-R nrPDB 42 7e-04 6CB1-s nrPDB 42 9e-04 5K19-A nrPDB 42 0.001 6ID0-T nrPDB 42 0.001 6C0F-s nrPDB 42 0.001 6EM1-m nrPDB 41 0.001 4AEZ-A nrPDB 41 0.001 4J0X-A nrPDB 41 0.002 3ACP-A nrPDB 41 0.002 6BX3-B nrPDB 41 0.002 4AV8-A nrPDB 41 0.002 5WLC-SG nrPDB 40 0.002 4OWR-A nrPDB 40 0.002 6EMK-B nrPDB 40 0.003 5UZ7-B nrPDB 40 0.003 5K0Y-T nrPDB 40 0.003 6E29-D nrPDB 40 0.004 3F3P-A nrPDB 39 0.005 6QDV-o nrPDB 39 0.007 5N4A-A nrPDB 39 0.010 5YZG-W nrPDB 38 0.013 5M89-A nrPDB 38 0.014 4U1E-I nrPDB 38 0.015 4BZK-B nrPDB 38 0.015 4XYI-A nrPDB 37 0.017 5A9Q-7 nrPDB 37 0.017 6CHG-A nrPDB 37 0.018 4L9O-A nrPDB 37 0.019 3JRP-A nrPDB 37 0.024 3JB9-S nrPDB 37 0.024 3JRO-A nrPDB 37 0.035 5WLC-LN nrPDB 37 0.037 6CHG-D nrPDB 36 0.044 5LTD-A nrPDB 36 0.057 3ODT-A nrPDB 35 0.072 5YZG-2 nrPDB 35 0.086 3BG0-A nrPDB 35 0.095 5A9Q-2 nrPDB 35 0.11 5MWJ-A nrPDB 35 0.14 2P9P-C nrPDB 34 0.15 5WYJ-BE nrPDB 34 0.15 5BJS-A nrPDB 34 0.15 5CXB-B nrPDB 34 0.17 4PSX-B nrPDB 34 0.18 5OQL-L nrPDB 33 0.34 5WLC-LJ nrPDB 33 0.46 3W15-A nrPDB 33 0.47 2I3T-A nrPDB 33 0.53 1XFD-A nrPDB 32 0.59 4XFV-A nrPDB 32 0.61 2PM9-A nrPDB 32 0.62 3DW8-B nrPDB 32 0.68 5BPT-A nrPDB 32 0.78 4CKE-A nrPDB 32 1.1 6FAH-B nrPDB 32 1.2 6ELZ-p nrPDB 31 1.3 5WLC-LS nrPDB 31 1.4 4E5Z-B nrPDB 30 2.3 4D3F-A nrPDB 30 2.6 5TF2-A nrPDB 30 2.7 3DWL-C nrPDB 30 4.1 6IYY-A nrPDB 29 6.3 5FA5-B nrPDB 29 7.2 5AMS-A nrPDB 28 8.4 6ILS-A nrPDB 28 8.5 1RY6-A nrPDB 28 8.9 >1NR0-A nrPDB Length = 611 Score = 1244 bits (3220), Expect = 0.0, Method: Compositional matrix adjust. Identities = 611/611 (100%), Positives = 611/611 (100%) Query: 1 MSEFSQTALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSH 60 MSEFSQTALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSH Sbjct: 1 MSEFSQTALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSH 60 Query: 61 QTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAA 120 QTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAA Sbjct: 61 QTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAA 120 Query: 121 VGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPF 180 VGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPF Sbjct: 121 VGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPF 180 Query: 181 KFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSG 240 KFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSG Sbjct: 181 KFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSG 240 Query: 241 SVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSI 300 SVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSI Sbjct: 241 SVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSI 300 Query: 301 SANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNR 360 SANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNR Sbjct: 301 SANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNR 360 Query: 361 VFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVS 420 VFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVS Sbjct: 361 VFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVS 420 Query: 421 ADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGA 480 ADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGA Sbjct: 421 ADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGA 480 Query: 481 SVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVA 540 SVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVA Sbjct: 481 SVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVA 540 Query: 541 CVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQ 600 CVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQ Sbjct: 541 CVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQ 600 Query: 601 DSNIKFWNVPF 611 DSNIKFWNVPF Sbjct: 601 DSNIKFWNVPF 611 >1PI6-A nrPDB Length = 615 Score = 249 bits (636), Expect = 2e-66, Method: Compositional matrix adjust. Identities = 202/649 (31%), Positives = 323/649 (49%), Gaps = 77/649 (11%) Query: 1 MSEFSQTALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTE------- 53 MS S + P P T R L P + I Y G S + V L D + Sbjct: 1 MSSISLKEIIPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAF---VRCLDDGDSKVPPVV 57 Query: 54 IYTEH-SHQTTVAKTSP---SGYYCASGDVHGNVRIW------DTTQTTHILKTTIPVFS 103 +T H S T K SP S Y C SGD G V +W ++ +K+ V + Sbjct: 58 QFTGHGSSVVTTVKFSPIKGSQYLC-SGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLA 116 Query: 104 GPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRI 163 GP+ DISWD E +R+ VGEGR+ FG +D+G S G ++G ++ +N+ K SRP R Sbjct: 117 GPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRS 176 Query: 164 ISGSDDNTVAIFEGPPFKFKSTFGEHTK---FVHSVRYNPD-GSLFASTGGDGTIVLYNG 219 ++ DD +V ++GPPFKF ++ H K FV V ++PD G + G D I ++G Sbjct: 177 MTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDG 236 Query: 220 VDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLK-VEKTIP 278 G EDD G +F L+W D K A+ AD TI++W+V T K V+K Sbjct: 237 KSGEFLKYIEDD---QEPVQGGIFALSW-LDSQKFATVGADATIRVWDVTTSKCVQKWTL 292 Query: 279 VGTRIEDQQLGIIWTKQA-LVSISANGFINFVNPELGSIDQVRY--GHNKAITALSSSAD 335 ++ +QQ+G++ T ++S+S +G +NF ELG + ++ GHNK ITAL+ + Sbjct: 293 DKQQLGNQQVGVVATGNGRIISLSLDGTLNFY--ELGHDEVLKTISGHNKGITALTVNP- 349 Query: 336 GKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPA 395 L S +G I W S+ + H+ +I + + + ++SWDD LKV Sbjct: 350 ---LISGSYDGRIMEWSSSSMHQD------HSNLIVSLDNSKAQEYSSISWDDTLKV--- 397 Query: 396 GGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSH--GKLTEVPISYNSSC 453 +G+ ++ SQP + + DG AV + I G + + + NS Sbjct: 398 --NGI-----TKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIK-SVRLNSPG 449 Query: 454 VALSNDKQFVAVGGQD-SKVHVYKLSGASVS-EVKTIVHPAEITSVAFSNNGAFLVATDQ 511 A+S + +VAVG ++ + + V+KLS VS ++KT + A+ + ++ S + ++ A D Sbjct: 450 SAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLR-AKPSYISISPSETYIAAGDV 508 Query: 512 SRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP----------DNVRLATGSLDNSVI 561 K++ Y + + T+ W F T+K+ +SW P + +ATGSLD ++ Sbjct: 509 MGKILLYDLQS--REVKTSRWAFRTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIF 566 Query: 562 VWNMNKPSDHPIIIKGAHA-MSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 ++++ +P IIK +A VN+++W +T+VS+G D+ IK WNV Sbjct: 567 IYSVKRPMK---IIKALNAHKDGVNNLLWETPSTLVSSGADACIKRWNV 612 >3DM0-A nrPDB Length = 694 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 83/311 (26%), Positives = 140/311 (45%), Gaps = 59/311 (18%) Query: 56 TEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDI---SWD 112 T HSH S G + SG G +R+WD + F G KD+ ++ Sbjct: 427 TGHSHFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRR-----FVGHTKDVLSVAFS 481 Query: 113 SESKRIAAVGEGRERFGHVFLFDT-GTSNGNLT----GQARAMNSVDFKPS--RPFRIIS 165 ++++I V R+R + L++T G ++ G ++ V F P+ +P I+S Sbjct: 482 LDNRQI--VSASRDR--TIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQP-TIVS 536 Query: 166 GSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKT 225 S D TV ++ K +ST HT +V +V +PDGSL AS G DG ++L++ +G K Sbjct: 537 ASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKL 596 Query: 226 GVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIED 285 E +S+ + L +SP+ + +A+ + IKIW++ + + + + V + E Sbjct: 597 YSLEANSV--------IHALCFSPNRYWLCAAT-EHGIKIWDLESKSIVEDLKVDLKAEA 647 Query: 286 QQL---GIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSA 342 ++ G TK+ ++ T+L+ SADG TLFS Sbjct: 648 EKADNSGPAATKRKVIY---------------------------CTSLNWSADGSTLFSG 680 Query: 343 DAEGHINSWDI 353 +G I W I Sbjct: 681 YTDGVIRVWGI 691 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 36/159 (22%), Positives = 70/159 (44%), Gaps = 10/159 (6%) Query: 458 NDKQFVAVGGQDSKVHVYKLS----GASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSR 513 ++ + +D + ++KL+ V++ + H + V S++G F ++ Sbjct: 393 DNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQFALSGSWDG 452 Query: 514 KVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPI 573 ++ + +A T + HT V V++S DN ++ + S D ++ +WN + I Sbjct: 453 ELRLWDLAAG---VSTRRFVGHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTLGECKYTI 509 Query: 574 IIKGAHAMSSVNSVIWLNET---TIVSAGQDSNIKFWNV 609 G V+ V + T TIVSA D +K WN+ Sbjct: 510 SEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNL 548 Score = 37.7 bits (86), Expect = 0.015, Method: Compositional matrix adjust. Identities = 63/278 (22%), Positives = 112/278 (40%), Gaps = 44/278 (15%) Query: 322 GHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDL 381 GH+ + + S+DG+ S +G + WD++ G+S R F +++ + + Sbjct: 428 GHSHFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQI 487 Query: 382 FTVSWDDHLKV----------VPAGGSG----VDSSKAVANKLSSQPLGLAVSADGDIAV 427 + S D +K+ + GG G V + N L QP ++ S D + V Sbjct: 488 VSASRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTL--QPTIVSASWDKTVKV 545 Query: 428 ---AACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSE 484 + C + H S VA+S D A GG+D V ++ L A + Sbjct: 546 WNLSNCKLRSTLAGHTGYV--------STVAVSPDGSLCASGGKDGVVLLWDL--AEGKK 595 Query: 485 VKTIVHPAEITSVAFSNNGAFLV-ATDQSRKVIPY---SVANNFEL-------AHTNSWT 533 + ++ + I ++ FS N +L AT+ K+ S+ + ++ NS Sbjct: 596 LYSLEANSVIHALCFSPNRYWLCAATEHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGP 655 Query: 534 FHTAK--VACVS--WSPDNVRLATGSLDNSVIVWNMNK 567 T + + C S WS D L +G D + VW + + Sbjct: 656 AATKRKVIYCTSLNWSADGSTLFSGYTDGVIRVWGIGR 693 Score = 28.5 bits (62), Expect = 9.9, Method: Compositional matrix adjust. Identities = 28/123 (22%), Positives = 53/123 (43%), Gaps = 7/123 (5%) Query: 490 HPAEITSVAFS-NNGAFLVATDQSRKVIPYSVANN---FELAHTNSWTFHTAKVACVSWS 545 H +T++A +N +V+ + + +I + + + + +A T H+ V V S Sbjct: 381 HTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRL-TGHSHFVEDVVLS 439 Query: 546 PDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIK 605 D +GS D + +W++ + H ++ L+ IVSA +D IK Sbjct: 440 SDGQFALSGSWDGELRLWDLAAGVSTRRFV--GHTKDVLSVAFSLDNRQIVSASRDRTIK 497 Query: 606 FWN 608 WN Sbjct: 498 LWN 500 >2H9P-A nrPDB Length = 329 Score = 71.6 bits (174), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 98/219 (44%), Gaps = 11/219 (5%) Query: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKR 117 H+ + K SP+G + AS ++IW + TI + D++W S+S Sbjct: 39 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--FEKTISGHKLGISDVAWSSDSNL 96 Query: 118 IAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEG 177 + + + + ++ +G L G + + +F P I+SGS D +V I++ Sbjct: 97 LVSASDDKTL--KIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL-IVSGSFDESVRIWDV 153 Query: 178 PPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 K T H+ V +V +N DGSL S+ DG +++ G DD V+ Sbjct: 154 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 213 Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKT 276 + +SP+G I +A+ D T+K+W+ + K KT Sbjct: 214 F------VKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 246 Score = 68.2 bits (165), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 59/222 (26%), Positives = 103/222 (46%), Gaps = 21/222 (9%) Query: 178 PPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 P + K T HTK V SV+++P+G AS+ D I ++ DG FE K ++ Sbjct: 28 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK----FE----KTIS 79 Query: 238 -HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIP-----VGTRIEDQQLGII 291 H + + WS D + SAS DKT+KIW+V++ K KT+ V + Q +I Sbjct: 80 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 139 Query: 292 WTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 VS S + + + + G + H+ ++A+ + DG + S+ +G W Sbjct: 140 ------VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 193 Query: 352 DISTGISNRVFPDVHATMITGIKTTSKGD-LFTVSWDDHLKV 392 D ++G + D ++ +K + G + + D+ LK+ Sbjct: 194 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 235 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 70/289 (24%), Positives = 120/289 (41%), Gaps = 32/289 (11%) Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGI---IWTK 294 H+ +V + +SP+G +AS+SADK IKIW K EKT I +LGI W+ Sbjct: 39 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT------ISGHKLGISDVAWSS 92 Query: 295 QA--LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 + LVS S + + + G + GH+ + + + + S + + WD Sbjct: 93 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 152 Query: 353 ISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSS 412 + TG + P H+ ++ + G L S D L + SG K + + + Sbjct: 153 VKTGKCLKTLP-AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG-QCLKTLIDDDNP 210 Query: 413 QPLGLAVSADGDIAVAACYKH---IAIYSHGKLTEVPISY-NSSCVALSN----DKQFVA 464 + S +G +AA + + YS GK + + N +N +++ Sbjct: 211 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 270 Query: 465 VGGQDSKVHVY---------KLSGASVSEVKTIVHPAE--ITSVAFSNN 502 G +D+ V+++ KL G + + T HP E I S A N+ Sbjct: 271 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALEND 319 Score = 34.3 bits (77), Expect = 0.16, Method: Compositional matrix adjust. Identities = 42/164 (25%), Positives = 63/164 (38%), Gaps = 7/164 (4%) Query: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKR 117 HS + + G S G RIWDT + LKT I + PV + + K Sbjct: 165 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA-SGQCLKTLIDDDNPPVSFVKFSPNGKY 223 Query: 118 IAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSV--DFKPSRPFRIISGSDDNTVAIF 175 I A + ++ + G TG + +F + I+SGS+DN V I+ Sbjct: 224 ILAAT--LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 281 Query: 176 EGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTG--GDGTIVLY 217 + HT V S +P ++ AS D TI L+ Sbjct: 282 NLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 325 Score = 33.9 bits (76), Expect = 0.21, Method: Compositional matrix adjust. Identities = 36/161 (22%), Positives = 72/161 (44%), Gaps = 14/161 (8%) Query: 452 SCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV--HPAEITSVAFSNNGAFLVAT 509 S V S + +++A D + ++ GA + + + H I+ VA+S++ LV+ Sbjct: 44 SSVKFSPNGEWLASSSADKLIKIW---GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 100 Query: 510 DQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPS 569 + + + V++ L H+ V C +++P + + +GS D SV +W++ Sbjct: 101 SDDKTLKIWDVSSGKCLKTLKG---HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 157 Query: 570 DHPIIIKGAHAMSSVNSVIWLNE--TTIVSAGQDSNIKFWN 608 +K A S S + N + IVS+ D + W+ Sbjct: 158 ----CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 194 Score = 32.0 bits (71), Expect = 0.79, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 46/100 (46%), Gaps = 6/100 (6%) Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 Q + P V N+ L T + HT V+ V +SP+ LA+ S D + +W Sbjct: 17 QGTQSKPTPVKPNYALKFTLA--GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKF 74 Query: 571 HPIIIKGAHAMSSVNSVIWLNETT-IVSAGQDSNIKFWNV 609 I H + ++ V W +++ +VSA D +K W+V Sbjct: 75 EKTI--SGHKL-GISDVAWSSDSNLLVSASDDKTLKIWDV 111 Score = 28.5 bits (62), Expect = 9.1, Method: Compositional matrix adjust. Identities = 55/295 (18%), Positives = 111/295 (37%), Gaps = 56/295 (18%) Query: 322 GHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDL 381 GH KA++++ S +G+ L S+ A+ I W G + H I+ + +S +L Sbjct: 38 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG-HKLGISDVAWSSDSNL 96 Query: 382 FTVSWDDH-LKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHG 440 + DD LK+ D++ C K + +S+ Sbjct: 97 LVSASDDKTLKI------------------------------WDVSSGKCLKTLKGHSNY 126 Query: 441 KLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTI-VHPAEITSVAF 499 C + + G D V ++ + +KT+ H +++V F Sbjct: 127 VF----------CCNFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAVHF 174 Query: 500 SNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNS 559 + +G+ +V++ + A+ L V+ V +SP+ + +LDN+ Sbjct: 175 NRDGSLIVSSSYDGLCRIWDTASGQCLKTLID--DDNPPVSFVKFSPNGKYILAATLDNT 232 Query: 560 VIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT-----IVSAGQDSNIKFWNV 609 + +W+ +K +K + I+ N + IVS +D+ + WN+ Sbjct: 233 LKLWDYSKGK----CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 283 >5M25-A nrPDB Length = 434 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 69/277 (24%), Positives = 124/277 (44%), Gaps = 16/277 (5%) Query: 120 AVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPP 179 A +G+E FL+D + T + M D + +I GS + P Sbjct: 76 AKRQGKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHREQI-GGSATQSKPTPVKPN 134 Query: 180 FKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA-H 238 + K T HTK V SV+++P+G AS+ D I ++ DG FE K ++ H Sbjct: 135 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK----FE----KTISGH 186 Query: 239 SGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA-- 296 + + WS D + SAS DKT+KIW+V++ K KT+ + + + Q+ Sbjct: 187 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHS---NYVFCCNFNPQSNL 243 Query: 297 LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 +VS S + + + + G + H+ ++A+ + DG + S+ +G WD ++G Sbjct: 244 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 303 Query: 357 ISNRVFPDVHATMITGIKTTSKGD-LFTVSWDDHLKV 392 + D ++ +K + G + + D+ LK+ Sbjct: 304 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 340 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 99/219 (45%), Gaps = 11/219 (5%) Query: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKR 117 H+ + K SP+G + AS ++IW + TI + D++W S+S Sbjct: 144 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--FEKTISGHKLGISDVAWSSDSNL 201 Query: 118 IAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEG 177 + + + ++ ++ +G L G + + +F P I+SGS D +V I++ Sbjct: 202 LVSASD--DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL-IVSGSFDESVRIWDV 258 Query: 178 PPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 K T H+ V +V +N DGSL S+ DG +++ G DD V+ Sbjct: 259 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 318 Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKT 276 + +SP+G I +A+ D T+K+W+ + K KT Sbjct: 319 F------VKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 351 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 73/295 (24%), Positives = 119/295 (40%), Gaps = 44/295 (14%) Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGI---IWTK 294 H+ +V + +SP+G +AS+SADK IKIW K EKT I +LGI W+ Sbjct: 144 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT------ISGHKLGISDVAWSS 197 Query: 295 QA--LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 + LVS S + + + G + GH+ + + + + S + + WD Sbjct: 198 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 257 Query: 353 ISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSG------VDSSKAV 406 + TG + P H+ ++ + G L S D L + SG +D Sbjct: 258 VKTGKCLKTLP-AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 316 Query: 407 ANKLSSQPLG---LAVSADG-----DIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSN 458 + + P G LA + D D + C K Y+ K + I N S Sbjct: 317 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLK---TYTGHKNEKYCIFANFSVTG--- 370 Query: 459 DKQFVAVGGQDSKVHVY---------KLSGASVSEVKTIVHPAE--ITSVAFSNN 502 +++ G +D+ V+++ KL G + + T HP E I S A N+ Sbjct: 371 -GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALEND 424 Score = 34.3 bits (77), Expect = 0.17, Method: Compositional matrix adjust. Identities = 36/161 (22%), Positives = 72/161 (44%), Gaps = 14/161 (8%) Query: 452 SCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV--HPAEITSVAFSNNGAFLVAT 509 S V S + +++A D + ++ GA + + + H I+ VA+S++ LV+ Sbjct: 149 SSVKFSPNGEWLASSSADKLIKIW---GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 205 Query: 510 DQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPS 569 + + + V++ L H+ V C +++P + + +GS D SV +W++ Sbjct: 206 SDDKTLKIWDVSSGKCLKTLKG---HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 262 Query: 570 DHPIIIKGAHAMSSVNSVIWLNE--TTIVSAGQDSNIKFWN 608 +K A S S + N + IVS+ D + W+ Sbjct: 263 ----CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 299 Score = 33.5 bits (75), Expect = 0.31, Method: Compositional matrix adjust. Identities = 42/164 (25%), Positives = 63/164 (38%), Gaps = 7/164 (4%) Query: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKR 117 HS + + G S G RIWDT + LKT I + PV + + K Sbjct: 270 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA-SGQCLKTLIDDDNPPVSFVKFSPNGKY 328 Query: 118 IAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSV--DFKPSRPFRIISGSDDNTVAIF 175 I A + ++ + G TG + +F + I+SGS+DN V I+ Sbjct: 329 ILAAT--LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 386 Query: 176 EGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTG--GDGTIVLY 217 + HT V S +P ++ AS D TI L+ Sbjct: 387 NLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 430 Score = 32.7 bits (73), Expect = 0.52, Method: Compositional matrix adjust. Identities = 27/94 (28%), Positives = 43/94 (45%), Gaps = 6/94 (6%) Query: 517 PYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIK 576 P V N+ L T HT V+ V +SP+ LA+ S D + +W I Sbjct: 128 PTPVKPNYALKFT--LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI-- 183 Query: 577 GAHAMSSVNSVIWLNETT-IVSAGQDSNIKFWNV 609 H + ++ V W +++ +VSA D +K W+V Sbjct: 184 SGHKL-GISDVAWSSDSNLLVSASDDKTLKIWDV 216 Score = 28.9 bits (63), Expect = 6.3, Method: Compositional matrix adjust. Identities = 55/295 (18%), Positives = 111/295 (37%), Gaps = 56/295 (18%) Query: 322 GHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDL 381 GH KA++++ S +G+ L S+ A+ I W G + H I+ + +S +L Sbjct: 143 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG-HKLGISDVAWSSDSNL 201 Query: 382 FTVSWDDH-LKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHG 440 + DD LK+ D++ C K + +S+ Sbjct: 202 LVSASDDKTLKI------------------------------WDVSSGKCLKTLKGHSNY 231 Query: 441 KLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTI-VHPAEITSVAF 499 C + + G D V ++ + +KT+ H +++V F Sbjct: 232 VF----------CCNFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAVHF 279 Query: 500 SNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNS 559 + +G+ +V++ + A+ L V+ V +SP+ + +LDN+ Sbjct: 280 NRDGSLIVSSSYDGLCRIWDTASGQCLKTLID--DDNPPVSFVKFSPNGKYILAATLDNT 337 Query: 560 VIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT-----IVSAGQDSNIKFWNV 609 + +W+ +K +K + I+ N + IVS +D+ + WN+ Sbjct: 338 LKLWDYSKGK----CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 388 >5WYJ-BC nrPDB Length = 817 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 46/163 (28%), Positives = 81/163 (49%), Gaps = 8/163 (4%) Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 H K ++++ +P+ S+FA+ D T ++N +G + H ++ +++ Sbjct: 490 HEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLAN-------HKRGLWDVSFC 542 Query: 249 PDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINF 308 +A++S DKT+KIW++ T V KT+ T Q+ I ++ L+S A+G I Sbjct: 543 QYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAV-QRCSFINKQKQLISCGADGLIKI 601 Query: 309 VNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 + G + GHN + ALS+ DG + SADA+G W Sbjct: 602 WDCSSGECLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFW 644 Score = 52.0 bits (123), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 41/147 (27%), Positives = 68/147 (46%), Gaps = 4/147 (2%) Query: 237 AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTR-IEDQQLGIIWTKQ 295 AH + L+ SP+ + A+AS DKT KIWN+ ++E T+ R + D + + Sbjct: 489 AHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWD--VSFCQYDK 546 Query: 296 ALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIST 355 L + S + + + + S+ + GH A+ S K L S A+G I WD S+ Sbjct: 547 LLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSS 606 Query: 356 GISNRVFPDVHATMITGIKTTSKGDLF 382 G + D H + + T + GD+ Sbjct: 607 GECLKTL-DGHNNRLWALSTMNDGDMI 632 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 34/138 (24%), Positives = 50/138 (36%), Gaps = 10/138 (7%) Query: 134 FDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFV 193 + G L R + V F + + S D TV I+ F T HT V Sbjct: 520 LENGELEATLANHKRGLWDVSFCQYDKL-LATSSGDKTVKIWSLDTFSVMKTLEGHTNAV 578 Query: 194 HSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV-AHSGSVFGLTWSPDGT 252 + S G DG I +++ G + LK + H+ ++ L+ DG Sbjct: 579 QRCSFINKQKQLISCGADGLIKIWDCSSG--------ECLKTLDGHNNRLWALSTMNDGD 630 Query: 253 KIASASADKTIKIWNVAT 270 I SA AD + W T Sbjct: 631 MIVSADADGVFQFWKDCT 648 >6QX9-4B nrPDB Length = 522 Score = 65.9 bits (159), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 63/211 (29%), Positives = 93/211 (44%), Gaps = 17/211 (8%) Query: 60 HQTTVAKT--SPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKR 117 H VA+ PSG + + + R+WD IL S V DI++ + Sbjct: 322 HTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQE--GHSMGVYDIAFHQDGS- 378 Query: 118 IAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEG 177 +A G G + FG V+ TG L G + + ++F P+ + I +GS DNT +++ Sbjct: 379 LAGTG-GLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPN-GYHIATGSGDNTCKVWDL 436 Query: 178 PPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGG-DGTIVLYNGVDGTKTGVFEDDSLKNV 236 + T H V V++ P F TG D T ++ T G LK + Sbjct: 437 RQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIW-----THPGW---SPLKTL 488 Query: 237 A-HSGSVFGLTWSPDGTKIASASADKTIKIW 266 A H G V GL S DG IA+ S D+T K+W Sbjct: 489 AGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 45.1 bits (105), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 25/90 (27%), Positives = 44/90 (48%), Gaps = 7/90 (7%) Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 H+ V+ + ++ DGSL + G D +++ G E H ++G+ +S Sbjct: 364 HSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLE-------GHLKEIYGINFS 416 Query: 249 PDGTKIASASADKTIKIWNVATLKVEKTIP 278 P+G IA+ S D T K+W++ + TIP Sbjct: 417 PNGYHIATGSGDNTCKVWDLRQRRCVYTIP 446 Score = 35.0 bits (79), Expect = 0.087, Method: Compositional matrix adjust. Identities = 50/245 (20%), Positives = 101/245 (41%), Gaps = 29/245 (11%) Query: 195 SVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV-AHSGSVFGLTWSPDGTK 253 +V +P AS DG++ L++ + D+ + ++ H+ V + W P G Sbjct: 286 TVSLDPKDVNLASCAADGSVKLWS--------LDSDEPVADIEGHTVRVARVMWHPSGRF 337 Query: 254 IASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGI----IWTKQALVSISA-NGFINF 308 + + D++ ++W+ L+ ++ I E +G+ +L + F Sbjct: 338 LGTTCYDRSWRLWD---LEAQEEI---LHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRV 391 Query: 309 VNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHAT 368 + G GH K I ++ S +G + + + WD+ P H Sbjct: 392 WDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIP-AHQN 450 Query: 369 MITGIKTTS-KGD-LFTVSWDDHLKV-VPAGGSGVDSSKAVANKLSSQPLGLAVSADGDI 425 ++TG+K G+ L T ++D+ K+ G S + + K+ +GL +S+DG + Sbjct: 451 LVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKV----MGLDISSDGQL 506 Query: 426 AVAAC 430 +A C Sbjct: 507 -IATC 510 Score = 31.2 bits (69), Expect = 1.6, Method: Compositional matrix adjust. Identities = 29/136 (21%), Positives = 58/136 (42%), Gaps = 7/136 (5%) Query: 474 VYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWT 533 ++ L G + + + HP S+ + A D S K+ +S+ ++ +A Sbjct: 266 LHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKL--WSLDSDEPVADIEG-- 321 Query: 534 FHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNET 593 HT +VA V W P L T D S +W++ + I+ + H+M + + + Sbjct: 322 -HTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEE--ILHQEGHSMGVYDIAFHQDGS 378 Query: 594 TIVSAGQDSNIKFWNV 609 + G D+ + W++ Sbjct: 379 LAGTGGLDAFGRVWDL 394 Score = 29.6 bits (65), Expect = 3.7, Method: Compositional matrix adjust. Identities = 11/33 (33%), Positives = 22/33 (66%) Query: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNMNK 567 H ++ +++SP+ +ATGS DN+ VW++ + Sbjct: 406 HLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQ 438 >6G51-g nrPDB Length = 317 Score = 65.1 bits (157), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 78/307 (25%), Positives = 135/307 (43%), Gaps = 61/307 (19%) Query: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDI---SWDSE 114 HSH + S G + SG G +R+WD T TT F G KD+ ++ S+ Sbjct: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTT-----GTTTRRFVGHTKDVLSVAFSSD 116 Query: 115 SKRIAAVGEGRERFGHVFLFDT-GTSNGNLTGQARA--MNSVDFKP--SRPFRIISGSDD 169 +++I V R++ + L++T G + ++ + ++ V F P S P I+S D Sbjct: 117 NRQI--VSGSRDK--TIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPI-IVSCGWD 171 Query: 170 NTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFE 229 V ++ K K+ HT ++++V +PDGSL AS G DG +L++ +G + Sbjct: 172 KLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231 Query: 230 DDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLG 289 + N L +SP+ + +A+ +IKIW++ G I D+ Sbjct: 232 GGDIIN--------ALCFSPNRYWLCAATG-PSIKIWDLE----------GKIIVDE--- 269 Query: 290 IIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHIN 349 KQ ++S S+ T+L+ SADG+TLF+ + + Sbjct: 270 ---LKQEVISTSSK------------------AEPPQCTSLAWSADGQTLFAGYTDNLVR 308 Query: 350 SWDISTG 356 W ++ G Sbjct: 309 VWQVTIG 315 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 61/232 (26%), Positives = 93/232 (40%), Gaps = 26/232 (11%) Query: 138 TSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFE--------GPPFKFKSTFGEH 189 T G L G + + P P I+S S D T+ +++ G P + H Sbjct: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIP---QRALRGH 62 Query: 190 TKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP 249 + FV V + DG S DGT+ L++ GT T F V H+ V + +S Sbjct: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRF-------VGHTKDVLSVAFSS 115 Query: 250 DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW-----TKQALVSISANG 304 D +I S S DKTIK+WN TL V K V + + + + +VS + Sbjct: 116 DNRQIVSGSRDKTIKLWN--TLGVCK-YTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172 Query: 305 FINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 + N + GH + ++ S DG S +G WD++ G Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEG 224 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 36/159 (22%), Positives = 71/159 (44%), Gaps = 11/159 (6%) Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGA--FLVATDQ 511 VA S+D + + G +D + ++ G V+ H ++ V FS N + +V+ Sbjct: 111 VAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGW 170 Query: 512 SRKVIPYSVAN-NFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 + V +++AN + H HT + V+ SPD A+G D ++W++N+ Sbjct: 171 DKLVKVWNLANCKLKTNHIG----HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE-GK 225 Query: 571 HPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 H + G +N++ + + A +IK W++ Sbjct: 226 HLYTLDGGDI---INALCFSPNRYWLCAATGPSIKIWDL 261 Score = 35.8 bits (81), Expect = 0.063, Method: Compositional matrix adjust. Identities = 62/269 (23%), Positives = 105/269 (39%), Gaps = 42/269 (15%) Query: 322 GHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDL 381 GH+ ++ + S+DG+ S +G + WD++TG + R F +++ ++ + Sbjct: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120 Query: 382 FTVSWDDHLKVVPAGG------------SGVDSSKAVANKLSSQPLGLAVSADGDIAV-- 427 + S D +K+ G V + N SS P+ ++ D + V Sbjct: 121 VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPN--SSNPIIVSCGWDKLVKVWN 178 Query: 428 -AACYKHIAIYSH-GKLTEVPISYNSS-CVALSNDKQFVAVGGQDSKVHVYKLSGASVSE 484 A C H G L V +S + S C + D Q + + K H+Y L G + Sbjct: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK-HLYTLDGGDI-- 235 Query: 485 VKTIVHPAEITSVAFSNNGAFLVAT--------DQSRKVIPYSVANNFELAHTNSWTFHT 536 I ++ FS N +L A D K+I + E+ T+S Sbjct: 236 ---------INALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQ--EVISTSS-KAEP 283 Query: 537 AKVACVSWSPDNVRLATGSLDNSVIVWNM 565 + ++WS D L G DN V VW + Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 Score = 34.3 bits (77), Expect = 0.14, Method: Compositional matrix adjust. Identities = 62/284 (21%), Positives = 111/284 (39%), Gaps = 35/284 (12%) Query: 249 PDGTKIASASADKTIKIWNVATLKVEKTIPV----GTRIEDQQLGIIWTKQALVSISANG 304 PD I SAS DKTI +W + + IP G + I Q +S S +G Sbjct: 28 PD--MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDG 85 Query: 305 FINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPD 364 + + G+ + GH K + +++ S+D + + S + I W+ V + Sbjct: 86 TLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDE 145 Query: 365 VHATMITGIK---TTSKGDLFTVSWDDHLKVVPAGGSGVDSSK----AVANKLSSQPLGL 417 H+ ++ ++ +S + + WD +KV + ++ N ++ P G Sbjct: 146 SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGS 205 Query: 418 AVSADGDIAVAACY-----KHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKV 472 ++ G A + KH+ G + N+ C + N A G + Sbjct: 206 LCASGGKDGQAMLWDLNEGKHLYTLDGGDI------INALCFS-PNRYWLCAATG--PSI 256 Query: 473 HVYKLSGA-SVSEVKTIV-------HPAEITSVAFSNNGAFLVA 508 ++ L G V E+K V P + TS+A+S +G L A Sbjct: 257 KIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 Score = 31.6 bits (70), Expect = 1.1, Method: Compositional matrix adjust. Identities = 22/76 (28%), Positives = 38/76 (50%), Gaps = 1/76 (1%) Query: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKG-AHAMSSVNSVIWLNET 593 HT V V++S DN ++ +GS D ++ +WN + + + + +S V + Sbjct: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNP 163 Query: 594 TIVSAGQDSNIKFWNV 609 IVS G D +K WN+ Sbjct: 164 IIVSCGWDKLVKVWNL 179 >5FL8-q nrPDB Length = 515 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 37/126 (29%), Positives = 63/126 (50%), Gaps = 8/126 (6%) Query: 141 GNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNP 200 +TG + +N V F P + I+S S DN++ +++G KF STF H V+ V ++ Sbjct: 396 ARMTGHQKLVNHVAFSPDGRY-IVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSS 454 Query: 201 DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASAD 260 D L S D T+ +++ +T S+ H V+ + WS DG ++ S D Sbjct: 455 DCRLLVSCSKDTTLKVWD----VRTRKL---SVDLPGHKDEVYTVDWSVDGKRVCSGGKD 507 Query: 261 KTIKIW 266 K +++W Sbjct: 508 KMVRLW 513 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 89/434 (20%), Positives = 170/434 (39%), Gaps = 64/434 (14%) Query: 139 SNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRY 198 S+ + G + F P R+++G+ DNT I++ T H +V V + Sbjct: 135 SSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSW 194 Query: 199 NPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP-------DG 251 +PDG + A+ D TI L++ K+G D+L+ HS + L+W P Sbjct: 195 SPDGEVIATGSMDNTIRLWD----PKSGQCLGDALR--GHSKWITSLSWEPIHLVKPGSK 248 Query: 252 TKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNP 311 ++AS+S D TIKIW+ + + T+ T + + W Q L+ + Sbjct: 249 PRLASSSKDGTIKIWDTVSRVCQYTMSGHT---NSVSCVKWGGQGLLYSGS--------- 296 Query: 312 ELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGH-INSWDISTGISNRVFPDVHATMI 370 H++ + ++ G+ + + H +N +ST + R+ H Sbjct: 297 -----------HDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDH---- 341 Query: 371 TGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAAC 430 TG K ++ + + +++ K+ G +S + + + L +A Sbjct: 342 TGKKPSTPEEAQKKALENYEKICKKNG---NSEEMMVTASDDYTMFLWNPLKSTKPIARM 398 Query: 431 YKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYK-LSGASVSEVKTIV 489 H + +H VA S D +++ D+ + ++ G +S + Sbjct: 399 TGHQKLVNH--------------VAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRG-- 442 Query: 490 HPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNV 549 H A + VA+S++ LV+ + + + V + H +V V WS D Sbjct: 443 HVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTR---KLSVDLPGHKDEVYTVDWSVDGK 499 Query: 550 RLATGSLDNSVIVW 563 R+ +G D V +W Sbjct: 500 RVCSGGKDKMVRLW 513 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 98/449 (21%), Positives = 164/449 (36%), Gaps = 112/449 (24%) Query: 173 AIFEGPPF-KFKSTFGEHTKFVHSVRYNPDGSLFASTG-GDGTIVLYNGVDGTKTGVFED 230 A+F+ P + S H + + P S TG GD T +++ T + Sbjct: 125 AVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLK- 183 Query: 231 DSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGI 290 H V ++WSPDG IA+ S D TI++W+ + Q LG Sbjct: 184 ------GHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKS--------------GQCLG- 222 Query: 291 IWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALS-------SSADGKTLFSAD 343 D +R GH+K IT+LS L S+ Sbjct: 223 --------------------------DALR-GHSKWITSLSWEPIHLVKPGSKPRLASSS 255 Query: 344 AEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKV--VPAGGSGVD 401 +G I WD + + H ++ +K +G L++ S D ++V + + G ++ Sbjct: 256 KDGTIKIWDTVSRVCQYTMSG-HTNSVSCVKWGGQGLLYSGSHDRTVRVWDINSQGRCIN 314 Query: 402 SSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQ 461 K+ A+ ++ L++S D + + A + H GK P AL N ++ Sbjct: 315 ILKSHAHWVNH----LSLSTDYALRIGA-FDHT-----GKKPSTPEEAQKK--ALENYEK 362 Query: 462 FVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVA 521 G ++ V A + FL +S K I Sbjct: 363 ICKKNGNSEEMMV----------------------TASDDYTMFLWNPLKSTKPIARM-- 398 Query: 522 NNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAM 581 T H V V++SPD + + S DNS+ +W+ D I + Sbjct: 399 -----------TGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGR---DGKFISTFRGHV 444 Query: 582 SSVNSVIWLNETT-IVSAGQDSNIKFWNV 609 +SV V W ++ +VS +D+ +K W+V Sbjct: 445 ASVYQVAWSSDCRLLVSCSKDTTLKVWDV 473 >5GAN-H nrPDB Length = 465 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 72/300 (24%), Positives = 122/300 (40%), Gaps = 47/300 (15%) Query: 75 ASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISW--DSESKRIAAVGEG-------- 124 A+G G++++ ++ QT L + G + I W DS ++ I+ +G Sbjct: 191 ATGSWAGDLQVLNS-QTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYS 249 Query: 125 RERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKS 184 E G L G+L G R ++ V + PS F I S S D T +++ + Sbjct: 250 NEEGGLRLL-------GDLVGHERRISDVKYHPSGKF-IGSASHDMTWRLWDASTHQELL 301 Query: 185 TFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFG 244 H K V S+ + DGSL S G D +L++ G+K HS ++ Sbjct: 302 LQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTL-------AGHSKPIYT 354 Query: 245 LTWSPDGTKIASASADKTIKIWNVA--------TLKVEKTIPVGTRIEDQQLGIIWTKQA 296 + WSP+G ++A+ D I +W++ + + I R + G + Sbjct: 355 VAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGG-----KK 409 Query: 297 LVSISANGFINFVNPE----LGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 LVS + IN + + +GS+ GH I +L S + L S + I W+ Sbjct: 410 LVSCGYDNLINVYSSDTWLKMGSL----AGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/232 (18%), Positives = 83/232 (35%), Gaps = 59/232 (25%) Query: 150 MNSVDFKPSRPFRIISGSDDNTVAIF----EGPPFKFKSTFGEHTKFVHSVRYNPDGSLF 205 + ++D+ P ++IS ++D + F E + H + + V+Y+P G Sbjct: 221 IGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFI 280 Query: 206 ASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKI 265 S D T L++ + + E H VF L++ DG+ + S D + Sbjct: 281 GSASHDMTWRLWDASTHQELLLQE-------GHDKGVFSLSFQCDGSLVCSGGMDSLSML 333 Query: 266 WNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNK 325 W++ + GS GH+K Sbjct: 334 WDIRS-------------------------------------------GSKVMTLAGHSK 350 Query: 326 AITALSSSADGKTLFSADAEGHINSWDIS---TGISNRVFPDVHATMITGIK 374 I ++ S +G + + +G IN WDI G N++ H ++T ++ Sbjct: 351 PIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQIL--AHRNIVTQVR 400 Score = 36.2 bits (82), Expect = 0.043, Method: Compositional matrix adjust. Identities = 45/221 (20%), Positives = 88/221 (39%), Gaps = 30/221 (13%) Query: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTT---IPVFSGPVKDISWDSE 114 H + + K PSG + S R+WD + +L VFS +S+ + Sbjct: 264 HERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFS-----LSFQCD 318 Query: 115 SKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAI 174 + + G + ++ +G+ L G ++ + +V + P+ +++ +G D + + Sbjct: 319 GSLVCS--GGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPN-GYQVATGGGDGIINV 375 Query: 175 F------EGPPFKFKSTFGEHTKFVHSVRYNPD--GSLFASTGGDGTIVLYNGVDGTKTG 226 + EG + + H V VR++ + G S G D I +Y+ K G Sbjct: 376 WDIRKRDEGQLNQILA----HRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMG 431 Query: 227 VFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 H+ + L S + + S D++IK+WN Sbjct: 432 SL-------AGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 32.0 bits (71), Expect = 0.76, Method: Compositional matrix adjust. Identities = 29/118 (24%), Positives = 52/118 (44%), Gaps = 14/118 (11%) Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV-HPAEITSVAFSNNGAFLVATDQS 512 VA S + VA GG D ++V+ + ++ I+ H +T V FS D Sbjct: 355 VAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKE-------DGG 407 Query: 513 RKVIPYSVANNFELAHTNSWTF------HTAKVACVSWSPDNVRLATGSLDNSVIVWN 564 +K++ N + +++W HT K+ + S ++ L +G D S+ +WN Sbjct: 408 KKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 30.8 bits (68), Expect = 2.0, Method: Compositional matrix adjust. Identities = 12/36 (33%), Positives = 22/36 (61%) Query: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 H+ + V+WSP+ ++ATG D + VW++ K + Sbjct: 348 HSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDE 383 Score = 29.3 bits (64), Expect = 4.7, Method: Compositional matrix adjust. Identities = 35/166 (21%), Positives = 60/166 (36%), Gaps = 56/166 (33%) Query: 236 VAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQ 295 V H + + + P G I SAS D T ++W+ +T Q Sbjct: 262 VGHERRISDVKYHPSGKFIGSASHDMTWRLWDAST-----------------------HQ 298 Query: 296 ALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIST 355 L+ ++ GH+K + +LS DG + S + WDI + Sbjct: 299 ELL--------------------LQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRS 338 Query: 356 GISNRVFPDVHATMITGIKTTSKGDLFTVSWD-DHLKVVPAGGSGV 400 G + + + SK ++TV+W + +V GG G+ Sbjct: 339 G-----------SKVMTLAGHSK-PIYTVAWSPNGYQVATGGGDGI 372 >6HHQ-h nrPDB Length = 319 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 66/237 (27%), Positives = 107/237 (45%), Gaps = 30/237 (12%) Query: 136 TGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHS 195 TG + G + SVD + IISGS D T+ ++ + G H +V Sbjct: 96 TGETYQRFVGHKSDVMSVDIDK-KASMIISGSRDKTIKVWTIKGQCLATLLG-HNDWVSQ 153 Query: 196 VRYNP------DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP 249 VR P D S G D + +N F+ ++ + H+ ++ LT SP Sbjct: 154 VRVVPNEKADDDSVTIISAGNDKMVKAWN------LNQFQIEA-DFIGHNSNINTLTASP 206 Query: 250 DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWT--KQALVSISANGFIN 307 DGT IASA D I +WN+A K T+ +D+ + ++ + L + +A G Sbjct: 207 DGTLIASAGKDGEIMLWNLAAKKAMYTLSA----QDEVFSLAFSPNRYWLAAATATGIKV 262 Query: 308 F-VNPELGSIDQVR---YGHNKA----ITALSSSADGKTLFSADAEGHINSWDISTG 356 F ++P+ +D +R G++KA +L+ SADG+TLF+ + I W + T Sbjct: 263 FSLDPQY-LVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTA 318 Score = 38.1 bits (87), Expect = 0.013, Method: Compositional matrix adjust. Identities = 60/261 (22%), Positives = 104/261 (39%), Gaps = 25/261 (9%) Query: 322 GHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDL 381 GH+ + + +ADG SA + + WD++TG + + F H + + + K + Sbjct: 63 GHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVG-HKSDVMSVDIDKKASM 121 Query: 382 -FTVSWDDHLKVVPAGGSG----------VDSSKAVANKLSSQPLGLAVSADGDIAVAAC 430 + S D +KV G V + V N+ + +SA D V A Sbjct: 122 IISGSRDKTIKVWTIKGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAW 181 Query: 431 YKHIAIYSHGKLTEVPISYNSSCVAL--SNDKQFVAVGGQDSKVHVYKLSGASVSEVKTI 488 + ++ I +NS+ L S D +A G+D ++ ++ L A+ + T+ Sbjct: 182 N-----LNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNL--AAKKAMYTL 234 Query: 489 VHPAEITSVAFSNNGAFL-VATDQSRKVI---PYSVANNFELAHTNSWTFHTAKVACVSW 544 E+ S+AFS N +L AT KV P + ++ ++W Sbjct: 235 SAQDEVFSLAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAW 294 Query: 545 SPDNVRLATGSLDNSVIVWNM 565 S D L G DN + VW + Sbjct: 295 SADGQTLFAGYTDNVIRVWQV 315 Score = 37.0 bits (84), Expect = 0.027, Method: Compositional matrix adjust. Identities = 42/164 (25%), Positives = 63/164 (38%), Gaps = 48/164 (29%) Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKV------------------------ 273 HS V T + DG SAS DKT+++W+VAT + Sbjct: 64 HSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMII 123 Query: 274 ----EKTIPVGTRIEDQQLGII-----WTKQA--------------LVSISANGFINFVN 310 +KTI V T I+ Q L + W Q ++S + + N Sbjct: 124 SGSRDKTIKVWT-IKGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWN 182 Query: 311 PELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIS 354 I+ GHN I L++S DG + SA +G I W+++ Sbjct: 183 LNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLA 226 Score = 29.3 bits (64), Expect = 5.1, Method: Compositional matrix adjust. Identities = 27/156 (17%), Positives = 63/156 (40%), Gaps = 5/156 (3%) Query: 456 LSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKV 515 L+ D + D + ++ ++ + + + H +++ SV + +++ + + + Sbjct: 73 LTADGAYALSASWDKTLRLWDVATGETYQ-RFVGHKSDVMSVDIDKKASMIISGSRDKTI 131 Query: 516 IPYSVANNF--ELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPI 573 +++ L N W V D+V + + D V WN+N+ Sbjct: 132 KVWTIKGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEAD 191 Query: 574 IIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 I ++++ + + T I SAG+D I WN+ Sbjct: 192 FIGHNSNINTLTASP--DGTLIASAGKDGEIMLWNL 225 >4A11-B nrPDB Length = 408 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 52/217 (23%), Positives = 91/217 (41%), Gaps = 25/217 (11%) Query: 201 DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA------HSGSVFGLTWSPDGTKI 254 +G S G DG IVLY+ + ++ + ++ ++ H SV + W P T + Sbjct: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGM 114 Query: 255 -ASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANG-FINFVNPE 312 S+S DKT+K+W+ TL+ + + + TK LV++ G + + + Sbjct: 115 FTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLK 174 Query: 313 LGSIDQVRYGHNKAITALS-SSADGKTLFSADAEGHINSWDISTGISNRVFPD------- 364 GS + GH + I A+S S L +A A+ + WD+ + D Sbjct: 175 SGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKS 234 Query: 365 --------VHATMITGIKTTSKG-DLFTVSWDDHLKV 392 H + G+ TS G L TV D+ +++ Sbjct: 235 QAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL 271 Score = 35.0 bits (79), Expect = 0.087, Method: Compositional matrix adjust. Identities = 41/189 (21%), Positives = 76/189 (40%), Gaps = 43/189 (22%) Query: 83 VRIWDTT--QTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFD--TGT 138 +++WDT QT + V+S + +S + AVG R V L D +G+ Sbjct: 124 LKVWDTNTLQTADVFNFEETVYSHHMSPVS---TKHCLVAVGT---RGPKVQLCDLKSGS 177 Query: 139 SNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRY 198 + L G + + +V + P + + + S D+ V +++ VR Sbjct: 178 CSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD-------------------VRR 218 Query: 199 NPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASAS 258 G ++ + +G K+ E N AH+G V GL ++ DG + + Sbjct: 219 -----------ASGCLITLDQHNGKKSQAVES---ANTAHNGKVNGLCFTSDGLHLLTVG 264 Query: 259 ADKTIKIWN 267 D +++WN Sbjct: 265 TDNRMRLWN 273 Score = 33.5 bits (75), Expect = 0.27, Method: Compositional matrix adjust. Identities = 24/89 (26%), Positives = 45/89 (50%), Gaps = 15/89 (16%) Query: 535 HTAKVACVSWSPD-NVRLATGSLDNSVIVWNMNKPSDHPIII-----KGAHAMSS----- 583 H ++ VSWSP + LAT S D+ V +W++ + S I + K + A+ S Sbjct: 185 HRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAH 244 Query: 584 ---VNSVIWLNE-TTIVSAGQDSNIKFWN 608 VN + + ++ +++ G D+ ++ WN Sbjct: 245 NGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 Score = 29.6 bits (65), Expect = 3.7, Method: Compositional matrix adjust. Identities = 31/117 (26%), Positives = 51/117 (43%), Gaps = 15/117 (12%) Query: 462 FVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVAT---DQSRKVIPY 518 VAVG + KV + L S S + H EI +V++S +++AT D K+ Sbjct: 158 LVAVGTRGPKVQLCDLKSGSCSHILQ-GHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 Query: 519 SVANNFEL-----------AHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWN 564 A+ + A ++ T H KV + ++ D + L T DN + +WN Sbjct: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 >6F3T-A nrPDB Length = 608 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 57/223 (25%), Positives = 96/223 (43%), Gaps = 22/223 (9%) Query: 50 TDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSG---PV 106 ++ +I HS A SP Y S G VR+W + QT T + + G PV Sbjct: 342 SELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLW-SLQTF----TCLVGYKGHNYPV 396 Query: 107 KDISWDSESKRIAA--VGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRII 164 WD++ V G +R ++ D G +N F P+ + + Sbjct: 397 ----WDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY-VA 451 Query: 165 SGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTK 224 +GS D TV +++ F H +HS+ ++P+G A+ DG ++L++ G Sbjct: 452 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLM 511 Query: 225 TGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 G + H+ +V L +S DG +AS S D T+++W+ Sbjct: 512 VGELK-------GHTDTVCSLRFSRDGEILASGSMDNTVRLWD 547 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 70/324 (21%), Positives = 127/324 (39%), Gaps = 68/324 (20%) Query: 250 DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFI-NF 308 D + IA AD T+++W+V K+ +++ + + +L+ ++ + Sbjct: 289 DSSLIAGGFADSTVRVWSVTPKKL-RSVKQASDL------------SLIDKESDDVLERI 335 Query: 309 VNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHAT 368 ++ + S ++ YGH+ + S S D L S+ +G + W + T T Sbjct: 336 MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT-----------FT 384 Query: 369 MITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVA 428 + G K G + V WD P G + G VA Sbjct: 385 CLVGYK----GHNYPV-WDTQFS----------------------PYGYYFVSGGHDRVA 417 Query: 429 AC-----YKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVS 483 Y+ + I++ G L +V +C + +VA G D V ++ + + Sbjct: 418 RLWATDHYQPLRIFA-GHLADV------NCTRFHPNSNYVATGSADRTVRLWDVLNGNCV 470 Query: 484 EVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVS 543 + T H I S+ FS NG FL +V+ + + + + HT V + Sbjct: 471 RIFT-GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKG---HTDTVCSLR 526 Query: 544 WSPDNVRLATGSLDNSVIVWNMNK 567 +S D LA+GS+DN+V +W+ K Sbjct: 527 FSRDGEILASGSMDNTVRLWDAIK 550 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 24/108 (22%), Positives = 52/108 (48%), Gaps = 7/108 (6%) Query: 161 FRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGV 220 + +SG D ++ ++ F H V+ R++P+ + A+ D T+ L++ + Sbjct: 406 YYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVL 465 Query: 221 DGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNV 268 +G +F H G + LT+SP+G +A+ + D + +W++ Sbjct: 466 NGNCVRIF-------TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI 506 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 47/210 (22%), Positives = 84/210 (40%), Gaps = 9/210 (4%) Query: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDG 202 L G + + F P R + ++S S+D TV ++ F + H V +++P G Sbjct: 347 LYGHSGPVYGASFSPDRNY-LLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYG 405 Query: 203 SLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKT 262 F S G D L+ +F H V + P+ +A+ SAD+T Sbjct: 406 YYFVSGGHDRVARLWATDHYQPLRIF-------AGHLADVNCTRFHPNSNYVATGSADRT 458 Query: 263 IKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYG 322 +++W+V + I G + L + L + + +G + + G + G Sbjct: 459 VRLWDVLNGNCVR-IFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKG 517 Query: 323 HNKAITALSSSADGKTLFSADAEGHINSWD 352 H + +L S DG+ L S + + WD Sbjct: 518 HTDTVCSLRFSRDGEILASGSMDNTVRLWD 547 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/183 (26%), Positives = 79/183 (43%), Gaps = 24/183 (13%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDIS---W 111 Y H++ + SP GYY SG R+W T + +F+G + D++ + Sbjct: 389 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQ-----PLRIFAGHLADVNCTRF 443 Query: 112 DSESKRIAAVGEGRERFGHVFLFDTGTSNGN----LTGQARAMNSVDFKPSRPFRIISGS 167 S +A R V L+D NGN TG ++S+ F P+ F + +G+ Sbjct: 444 HPNSNYVATGSADRT----VRLWDV--LNGNCVRIFTGHKGPIHSLTFSPNGRF-LATGA 496 Query: 168 DDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGV 227 D V +++ HT V S+R++ DG + AS D T+ L++ + Sbjct: 497 TDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKA----- 551 Query: 228 FED 230 FED Sbjct: 552 FED 554 >5NNZ-B nrPDB Length = 415 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 55/251 (21%), Positives = 100/251 (39%), Gaps = 23/251 (9%) Query: 26 NTPAGDKI---QYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGN 82 N P GDKI + +++V G T + H+ + +P A+G + Sbjct: 143 NNPYGDKIATGSFDKTCKLWSVETGKCYHT--FRGHTAEIVCLSFNPQSTLVATGSMDTT 200 Query: 83 VRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLF---DTGTS 139 ++WD + T+ S + +S+++ RI F H + DTG Sbjct: 201 AKLWDIQNGEEVY--TLRGHSAEIISLSFNTSGDRIIT-----GSFDHTVVVWDADTGRK 253 Query: 140 NGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYN 199 L G ++S F I++GS D T +++ K +T H + ++ Sbjct: 254 VNILIGHCAEISSASFNWDCSL-ILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFD 312 Query: 200 PDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASA 259 G L A+ DGT +++ E H G + ++++P G + + S+ Sbjct: 313 YTGKLIATASADGTARIFSAATRKCIAKLE-------GHEGEISKISFNPQGNHLLTGSS 365 Query: 260 DKTIKIWNVAT 270 DKT +IW+ T Sbjct: 366 DKTARIWDAQT 376 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 49/216 (22%), Positives = 87/216 (40%), Gaps = 10/216 (4%) Query: 133 LFDT--GTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHT 190 L+DT G L G + ++ F +I +GS D T ++ K TF HT Sbjct: 118 LWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHT 177 Query: 191 KFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD 250 + + +NP +L A+ D T L++ +G + HS + L+++ Sbjct: 178 AEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR-------GHSAEIISLSFNTS 230 Query: 251 GTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVN 310 G +I + S D T+ +W+ T + + I +G E W +++ S + + Sbjct: 231 GDRIITGSFDHTVVVWDADTGR-KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWD 289 Query: 311 PELGSIDQVRYGHNKAITALSSSADGKTLFSADAEG 346 G GH+ I GK + +A A+G Sbjct: 290 ATNGKCVATLTGHDDEILDSCFDYTGKLIATASADG 325 Score = 48.9 bits (115), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 48/231 (20%), Positives = 92/231 (39%), Gaps = 13/231 (5%) Query: 135 DTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVH 194 +TG G + + F P + +GS D T +++ + T H+ + Sbjct: 165 ETGKCYHTFRGHTAEIVCLSFNPQSTL-VATGSMDTTAKLWDIQNGEEVYTLRGHSAEII 223 Query: 195 SVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKI 254 S+ +N G + D T+V+++ G K + + H + +++ D + I Sbjct: 224 SLSFNTSGDRIITGSFDHTVVVWDADTGRKVNIL-------IGHCAEISSASFNWDCSLI 276 Query: 255 ASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGII--WTKQALVSISANGFINFVNPE 312 + S DKT K+W+ K T+ T +D+ L +T + + + SA+G + Sbjct: 277 LTGSMDKTCKLWDATNGKCVATL---TGHDDEILDSCFDYTGKLIATASADGTARIFSAA 333 Query: 313 LGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFP 363 GH I+ +S + G L + ++ WD TG +V Sbjct: 334 TRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLE 384 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/178 (24%), Positives = 69/178 (38%), Gaps = 9/178 (5%) Query: 180 FKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHS 239 F H + +V N GS F + D T L++ G + E H Sbjct: 82 FYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLE-------GHR 134 Query: 240 GSVFGLTWS-PDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALV 298 V+ + ++ P G KIA+ S DKT K+W+V T K T G E L + Sbjct: 135 NVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFR-GHTAEIVCLSFNPQSTLVA 193 Query: 299 SISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 + S + + + G GH+ I +LS + G + + + + WD TG Sbjct: 194 TGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTG 251 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 35/122 (28%), Positives = 62/122 (50%), Gaps = 11/122 (9%) Query: 490 HPAEITSVAFSNNGAFLVAT---DQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP 546 H AEI ++F N + LVAT D + K+ + + N E+ H+A++ +S++ Sbjct: 176 HTAEIVCLSF-NPQSTLVATGSMDTTAKL--WDIQNGEEVYTLRG---HSAEIISLSFNT 229 Query: 547 DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKF 606 R+ TGS D++V+VW+ + I+I +SS S W + + I++ D K Sbjct: 230 SGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSA-SFNW-DCSLILTGSMDKTCKL 287 Query: 607 WN 608 W+ Sbjct: 288 WD 289 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 30/114 (26%), Positives = 54/114 (47%), Gaps = 5/114 (4%) Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV-HPAEITSVAFSNNGAFLVATDQS 512 VAL+ G D ++ AS E+ T+ H + ++AF+N +AT Sbjct: 98 VALNKSGSCFITGSYDRTCKLW--DTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSF 155 Query: 513 RKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMN 566 K + HT + HTA++ C+S++P + +ATGS+D + +W++ Sbjct: 156 DKTCKLWSVETGKCYHT--FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 24/105 (22%), Positives = 41/105 (39%), Gaps = 7/105 (6%) Query: 163 IISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDG 222 I + S D T IF K + H + + +NP G+ + D T +++ G Sbjct: 318 IATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTG 377 Query: 223 TKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 V E H+ +F ++ G + + S D T +IW Sbjct: 378 QCLQVLE-------GHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415 Score = 28.9 bits (63), Expect = 7.1, Method: Compositional matrix adjust. Identities = 34/207 (16%), Positives = 74/207 (35%), Gaps = 19/207 (9%) Query: 411 SSQPLGLAVSADGDIAVAACYKHIAIY---SHGKLTEVPISYNSSCVALSN-----DKQF 462 S++ + L+ + GD + + H + G+ + I + C +S+ D Sbjct: 219 SAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGH---CAEISSASFNWDCSL 275 Query: 463 VAVGGQDSKVHVYKLSGASVSEVKTIV-HPAEITSVAFSNNGAFLVATDQSRKVIPYSVA 521 + G D ++ + V T+ H EI F G + +S A Sbjct: 276 ILTGSMDKTCKLWDATNGKC--VATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAA 333 Query: 522 NNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAM 581 +A H +++ +S++P L TGS D + +W+ + + + H Sbjct: 334 TRKCIAKLEG---HEGEISKISFNPQGNHLLTGSSDKTARIWDAQ--TGQCLQVLEGHTD 388 Query: 582 SSVNSVIWLNETTIVSAGQDSNIKFWN 608 + +++ +D+ + W Sbjct: 389 EIFSCAFNYKGNIVITGSKDNTCRIWR 415 >3FM0-A nrPDB Length = 345 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 66/274 (24%), Positives = 104/274 (37%), Gaps = 19/274 (6%) Query: 9 LFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTE---HSHQTTVA 65 L +P L PAG + C G + G+ D+ I HQ TV Sbjct: 7 LLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRI-WGTEGDSWICKSVLSEGHQRTVR 65 Query: 66 KT--SPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGE 123 K SP G Y AS IW Q TT+ VK ++W +A Sbjct: 66 KVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSR 125 Query: 124 GRERF-GHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF--EGPPF 180 + + V D L + + V + PS+ + S S D+TV ++ E + Sbjct: 126 DKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQEL-LASASYDDTVKLYREEEDDW 184 Query: 181 KFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNG-VDGTKTGVF---EDDSLKNV 236 +T H V S+ ++P G AS D T+ ++ + G + GV D S K + Sbjct: 185 VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244 Query: 237 A-----HSGSVFGLTWSPDGTKIASASADKTIKI 265 HS +++ + W +A+A D I++ Sbjct: 245 CTLSGFHSRTIYDIAWCQLTGALATACGDDAIRV 278 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 54/250 (21%), Positives = 91/250 (36%), Gaps = 39/250 (15%) Query: 163 IISGSDDNTVAIF--EGPPFKFKSTFGE-HTKFVHSVRYNPDGSLFASTGGDGTIVLY-- 217 + S D + I+ EG + KS E H + V V ++P G+ AS D T ++ Sbjct: 31 LASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKK 90 Query: 218 NGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTI 277 N D E H V + W+P G +A+ S DK++ +W V + + Sbjct: 91 NQDDFECVTTLE-------GHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECV 143 Query: 278 PVGTRIEDQQLGIIW--TKQALVSISANGFINFVNPELGS--IDQVRYGHNKAITALSSS 333 V ++W +++ L S S + + E GH + +L+ Sbjct: 144 SVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFD 203 Query: 334 ADGKTLFSADAEGHINSW----------------DIS-------TGISNRVFPDVHATMI 370 G+ L S + + W D S +G +R D+ + Sbjct: 204 PSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQL 263 Query: 371 TGIKTTSKGD 380 TG T+ GD Sbjct: 264 TGALATACGD 273 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 27/70 (38%), Positives = 38/70 (54%), Gaps = 4/70 (5%) Query: 198 YNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASA 257 +NP G+L AS GGD I ++ GT+ + S+ + H +V + WSP G +ASA Sbjct: 24 WNPAGTLLASCGGDRRIRIW----GTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASA 79 Query: 258 SADKTIKIWN 267 S D T IW Sbjct: 80 SFDATTCIWK 89 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 44/171 (25%), Positives = 74/171 (43%), Gaps = 8/171 (4%) Query: 442 LTEVPISYNSSC--VALSNDKQFVAVGGQDSKVHVYKLSGAS--VSEVKTIVHPAEITSV 497 L VP +S C +A + +A G D ++ ++ G S V + H + V Sbjct: 8 LGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKV 67 Query: 498 AFSNNGAFLV-ATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSL 556 A+S G +L A+ + I ++FE T H +V V+W+P LAT S Sbjct: 68 AWSPCGNYLASASFDATTCIWKKNQDDFECVTTLE--GHENEVKSVAWAPSGNLLATCSR 125 Query: 557 DNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW-LNETTIVSAGQDSNIKF 606 D SV VW +++ ++ + V V+W ++ + SA D +K Sbjct: 126 DKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL 176 Score = 30.4 bits (67), Expect = 2.3, Method: Compositional matrix adjust. Identities = 14/31 (45%), Positives = 19/31 (61%), Gaps = 1/31 (3%) Query: 237 AHSGS-VFGLTWSPDGTKIASASADKTIKIW 266 AH S + L W+P GT +AS D+ I+IW Sbjct: 13 AHPDSRCWFLAWNPAGTLLASCGGDRRIRIW 43 Score = 29.3 bits (64), Expect = 5.1, Method: Compositional matrix adjust. Identities = 39/171 (22%), Positives = 65/171 (38%), Gaps = 22/171 (12%) Query: 460 KQFVAVGGQDSKVHVYKLSGASVSEVKTIV-HPAEITSVAFSNNGAFLVATDQSRKVI-- 516 ++ +A D V +Y+ T+ H + + S+AF +G L + R V Sbjct: 162 QELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221 Query: 517 -PYSVANNFELAHTNS---WT-------FHTAKVACVSWSPDNVRLATGSLDNSVIVWNM 565 Y N +A + S W FH+ + ++W LAT D+++ V+ Sbjct: 222 RQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQE 281 Query: 566 NKPSD--HPIIIKGAHAMSS----VNSVIWLNET--TIVSAGQDSNIKFWN 608 + SD P AH + VN V W + + S D + FW Sbjct: 282 DPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWK 332 >3JAP-g nrPDB Length = 326 Score = 59.3 bits (142), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 63/244 (25%), Positives = 95/244 (38%), Gaps = 54/244 (22%) Query: 141 GNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFE--------GPPFKFKSTFGEHTKF 192 G L G + S+ ++P ++SGS D T+ + G P + ++ H+ Sbjct: 12 GTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVR---SYKGHSHI 68 Query: 193 VHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGT 252 V V + DG+ S D T+ L+N G F V H+G V + + + Sbjct: 69 VQDVVVSADGNYAVSASWDKTLRLWNLATGNSEARF-------VGHTGDVLSVAIDANSS 121 Query: 253 KIASASADKTIKIWNVA----------TLKVEKTIPVGTRIEDQQLGIIWTKQALVSISA 302 KI SAS DKTI++WN T V K +ED ++ Sbjct: 122 KIISASRDKTIRVWNTVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVD------------- 168 Query: 303 NGFINFVNPELGSI--------DQVR-----YGHNKAITALSSSADGKTLFSADAEGHIN 349 +G I FV+ + I D R GHN I + S DG SA +G I Sbjct: 169 DGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIY 228 Query: 350 SWDI 353 W++ Sbjct: 229 VWNL 232 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 74/337 (21%), Positives = 123/337 (36%), Gaps = 88/337 (26%) Query: 42 YTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTT----------QT 91 + VPV S Y HSH S G Y S +R+W+ T Sbjct: 55 FGVPVRS------YKGHSHIVQDVVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHT 108 Query: 92 THILKTTIPVFSGPVKDISWDSESKRIAAVGEG------------RERFGHVFLFDTGTS 139 +L I S + S D + VG+ + R L D Sbjct: 109 GDVLSVAIDANSSKIISASRDKTIRVWNTVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVD 168 Query: 140 NGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYN 199 +G +T + M+ + R S ++D+ ++ ++ F H +++ V+ + Sbjct: 169 DGRITFVSAGMDKI-------VRSWSLNEDS---------YRIEADFIGHNNYINVVQPS 212 Query: 200 PDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASA 259 PDGSL AS G DG I ++N + + N VF L +SP + +A+A Sbjct: 213 PDGSLAASAGKDGQIYVWN--------LKHKSAFMNFDAKDEVFALAFSPSRFWLTAATA 264 Query: 260 DKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQV 319 IKI++ +E++ L I+ + PE + Sbjct: 265 -SGIKIYD---------------LENEVL-----------------IDELKPEFAGYTKA 291 Query: 320 RYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 + H +L+ SADG+TLF+ + I W + T Sbjct: 292 QDPH---AVSLAWSADGQTLFAGYTDNVIRVWQVMTA 325 >6MZM-G nrPDB Length = 800 Score = 58.5 bits (140), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 94/220 (42%), Gaps = 22/220 (10%) Query: 53 EIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSG---PVKDI 109 +I HS A SP Y S G VR+W + QT T + + G PV Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLW-SLQTF----TCLVGYKGHNYPV--- 588 Query: 110 SWDSESKRIAA--VGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGS 167 WD++ V G +R ++ D G +N F P+ + + +GS Sbjct: 589 -WDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY-VATGS 646 Query: 168 DDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGV 227 D TV +++ F H +HS+ ++P+G A+ DG ++L++ G G Sbjct: 647 ADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGE 706 Query: 228 FEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 + H+ +V L +S DG +AS S D T+++W+ Sbjct: 707 LK-------GHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 59/255 (23%), Positives = 97/255 (38%), Gaps = 54/255 (21%) Query: 318 QVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTS 377 ++ YGH+ + S S D L S+ +G + W + T T + G K Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT-----------FTCLVGYK--- 582 Query: 378 KGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAAC-----YK 432 G + V WD P G + G VA Y+ Sbjct: 583 -GHNYPV-WDTQFS----------------------PYGYYFVSGGHDRVARLWATDHYQ 618 Query: 433 HIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPA 492 + I++ G L +V +C + +VA G D V ++ + + + T H Sbjct: 619 PLRIFA-GHLADV------NCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFT-GHKG 670 Query: 493 EITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLA 552 I S+ FS NG FL +V+ + + + + HT V + +S D LA Sbjct: 671 PIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKG---HTDTVCSLRFSRDGEILA 727 Query: 553 TGSLDNSVIVWNMNK 567 +GS+DN+V +W+ K Sbjct: 728 SGSMDNTVRLWDAIK 742 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 24/108 (22%), Positives = 52/108 (48%), Gaps = 7/108 (6%) Query: 161 FRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGV 220 + +SG D ++ ++ F H V+ R++P+ + A+ D T+ L++ + Sbjct: 598 YYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVL 657 Query: 221 DGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNV 268 +G +F H G + LT+SP+G +A+ + D + +W++ Sbjct: 658 NGNCVRIF-------TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI 698 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 47/210 (22%), Positives = 84/210 (40%), Gaps = 9/210 (4%) Query: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDG 202 L G + + F P R + ++S S+D TV ++ F + H V +++P G Sbjct: 539 LYGHSGPVYGASFSPDRNY-LLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYG 597 Query: 203 SLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKT 262 F S G D L+ +F H V + P+ +A+ SAD+T Sbjct: 598 YYFVSGGHDRVARLWATDHYQPLRIF-------AGHLADVNCTRFHPNSNYVATGSADRT 650 Query: 263 IKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYG 322 +++W+V + I G + L + L + + +G + + G + G Sbjct: 651 VRLWDVLNGNCVR-IFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKG 709 Query: 323 HNKAITALSSSADGKTLFSADAEGHINSWD 352 H + +L S DG+ L S + + WD Sbjct: 710 HTDTVCSLRFSRDGEILASGSMDNTVRLWD 739 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/183 (26%), Positives = 79/183 (43%), Gaps = 24/183 (13%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDIS---W 111 Y H++ + SP GYY SG R+W T + +F+G + D++ + Sbjct: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQ-----PLRIFAGHLADVNCTRF 635 Query: 112 DSESKRIAAVGEGRERFGHVFLFDTGTSNGN----LTGQARAMNSVDFKPSRPFRIISGS 167 S +A R V L+D NGN TG ++S+ F P+ F + +G+ Sbjct: 636 HPNSNYVATGSADRT----VRLWDV--LNGNCVRIFTGHKGPIHSLTFSPNGRF-LATGA 688 Query: 168 DDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGV 227 D V +++ HT V S+R++ DG + AS D T+ L++ + Sbjct: 689 TDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKA----- 743 Query: 228 FED 230 FED Sbjct: 744 FED 746 >4BH6-A nrPDB Length = 308 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 49/199 (24%), Positives = 90/199 (45%), Gaps = 19/199 (9%) Query: 163 IISGSDDNTVAIFE-GPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVD 221 + SGS D+ + + P F T HT+ V +++N + AS G D + +Y G Sbjct: 117 LTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTS 176 Query: 222 GTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIAS---ASADKTIKIWNVATLKVEKTIP 278 + F++ H +V + WSP + + +AD+ +KIWNV T I Sbjct: 177 KSPILTFDE-------HKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDID 229 Query: 279 VGTRIEDQQLGIIWTKQALVSISANGF--INFVNPELGSID--QVRYGHNKAITALSSSA 334 G++I ++W+K ++++G+ N + S+D + GH+ + L+ S Sbjct: 230 SGSQI----CNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSN 285 Query: 335 DGKTLFSADAEGHINSWDI 353 DG T+ S + + W + Sbjct: 286 DGTTVVSGAGDETLRYWKL 304 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 39/153 (25%), Positives = 78/153 (50%), Gaps = 14/153 (9%) Query: 463 VAVGGQDSKVHVYKLSGASVSEVKTI-VHPAEITSVAFSNNGAFLVAT---DQSRKVIPY 518 +A GG D+ VHVY+ G S S + T H A + ++A+S + ++AT R++ + Sbjct: 160 LASGGNDNVVHVYE--GTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIW 217 Query: 519 SVANNFELAHTNSWTFHTAKVACVSWSPDNVRLAT--GSLDNSVIVWNMNKPSDHPIIIK 576 +V + +++ +S +++ + WS + L T G ++ +W+ N S PI I Sbjct: 218 NVNTSIKMSDIDS----GSQICNMVWSKNTNELVTSHGYSKYNLTLWDCN--SMDPIAIL 271 Query: 577 GAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 H+ ++ + + TT+VS D +++W + Sbjct: 272 KGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 304 Score = 29.3 bits (64), Expect = 5.2, Method: Compositional matrix adjust. Identities = 23/79 (29%), Positives = 41/79 (51%), Gaps = 7/79 (8%) Query: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWL-NET 593 HT +V + W+ + +LA+G DN V V+ S PI+ H ++V ++ W ++ Sbjct: 144 HTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKS--PILTFDEHK-AAVKAMAWSPHKR 200 Query: 594 TIVSAG---QDSNIKFWNV 609 +++ G D +K WNV Sbjct: 201 GVLATGGGTADRRLKIWNV 219 >5G04-R nrPDB Length = 499 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 65/290 (22%), Positives = 112/290 (38%), Gaps = 66/290 (22%) Query: 71 GYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGH 130 G Y A G V++WD Q + T S V +SW+S I + G R GH Sbjct: 238 GNYLAVGTSSAEVQLWDVQQQKRLRNMT--SHSARVGSLSWNSY---ILSSGS---RSGH 289 Query: 131 VFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHT 190 + D + ++ VA G H+ Sbjct: 290 IHHHDVRVA-----------------------------EHHVATLSG-----------HS 309 Query: 191 KFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKN-VAHSGSVFGLTWSP 249 + V +R+ PDG AS G D + ++ G V L+ H G+V + W P Sbjct: 310 QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV----PLQTFTQHQGAVKAVAWCP 365 Query: 250 DGTKIAS---ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFI 306 + + + ++D+ I+IWNV + + +++ I+W+ IS +GF Sbjct: 366 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV----CSILWSPHYKELISGHGFA 421 Query: 307 N-----FVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 + P + + +++ GH + +L+ S DG T+ SA A+ + W Sbjct: 422 QNQLVIWKYPTMAKVAELK-GHTSRVLSLTMSPDGATVASAAADETLRLW 470 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 45/173 (26%), Positives = 80/173 (46%), Gaps = 15/173 (8%) Query: 444 EVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNG 503 E P Y SS VA + ++AVG ++V ++ + T H A + S+++ N Sbjct: 223 EQPGEYISS-VAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMT-SHSARVGSLSW--NS 278 Query: 504 AFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVW 563 L + +S + + V H + + H+ +V + W+PD LA+G DN V VW Sbjct: 279 YILSSGSRSGHIHHHDV--RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 336 Query: 564 NMNKPSDH---PIIIKGAHAMSSVNSVIWLN-ETTIVSAG---QDSNIKFWNV 609 + P + P+ H +V +V W ++ +++ G D +I+ WNV Sbjct: 337 P-SAPGEGGWVPLQTFTQH-QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 387 Score = 38.5 bits (88), Expect = 0.009, Method: Compositional matrix adjust. Identities = 39/166 (23%), Positives = 69/166 (41%), Gaps = 7/166 (4%) Query: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTT--QTTHILKTTIPVFSGPVKDISWDSES 115 HS + + +P G + ASG V +W + + + T G VK ++W Sbjct: 308 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQ 367 Query: 116 KRIAAVGEG-RERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSD--DNTV 172 + A G G +R ++ +G + ++ S+ + P +ISG N + Sbjct: 368 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVC-SILWSPHYK-ELISGHGFAQNQL 425 Query: 173 AIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN 218 I++ P + HT V S+ +PDG+ AS D T+ L+ Sbjct: 426 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 >5A31-R nrPDB Length = 386 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 49/199 (24%), Positives = 90/199 (45%), Gaps = 19/199 (9%) Query: 163 IISGSDDNTVAIFE-GPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVD 221 + SGS D+ + + P F T HT+ V +++N + AS G D + +Y G Sbjct: 186 LTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTS 245 Query: 222 GTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIAS---ASADKTIKIWNVATLKVEKTIP 278 + F++ H +V + WSP + + +AD+ +KIWNV T I Sbjct: 246 KSPILTFDE-------HKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDID 298 Query: 279 VGTRIEDQQLGIIWTKQALVSISANGF--INFVNPELGSID--QVRYGHNKAITALSSSA 334 G++I ++W+K ++++G+ N + S+D + GH+ + L+ S Sbjct: 299 SGSQI----CNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSN 354 Query: 335 DGKTLFSADAEGHINSWDI 353 DG T+ S + + W + Sbjct: 355 DGTTVVSGAGDETLRYWKL 373 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 39/153 (25%), Positives = 78/153 (50%), Gaps = 14/153 (9%) Query: 463 VAVGGQDSKVHVYKLSGASVSEVKTI-VHPAEITSVAFSNNGAFLVAT---DQSRKVIPY 518 +A GG D+ VHVY+ G S S + T H A + ++A+S + ++AT R++ + Sbjct: 229 LASGGNDNVVHVYE--GTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIW 286 Query: 519 SVANNFELAHTNSWTFHTAKVACVSWSPDNVRLAT--GSLDNSVIVWNMNKPSDHPIIIK 576 +V + +++ +S +++ + WS + L T G ++ +W+ N S PI I Sbjct: 287 NVNTSIKMSDIDS----GSQICNMVWSKNTNELVTSHGYSKYNLTLWDCN--SMDPIAIL 340 Query: 577 GAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 H+ ++ + + TT+VS D +++W + Sbjct: 341 KGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 373 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 68/313 (21%), Positives = 118/313 (37%), Gaps = 80/313 (25%) Query: 17 ARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCAS 76 A G ++ L + GD + C DTE E++ + + +G + A Sbjct: 109 ALGKSIFLTDNNTGDVVHLC--------------DTE--NEYTSLSWIG----AGSHLAV 148 Query: 77 GDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFL--- 133 G +G V I+D + + I SG + ++ S + + G R H + Sbjct: 149 GQANGLVEIYDVMK-----RKCIRTLSGHIDRVACLSWNNHVLTSGSRDHRILHRDVRMP 203 Query: 134 ---FDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHT 190 F+T S+ + N D K + SG +DN V ++EG TF EH Sbjct: 204 DPFFETIESHTQEVCGLK-WNVADNK------LASGGNDNVVHVYEGTSKSPILTFDEHK 256 Query: 191 KFVHSVRYNPDGSLFASTGG---DGTIVLYN----------------------------- 218 V ++ ++P +TGG D + ++N Sbjct: 257 AAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELV 316 Query: 219 ---GVDGTKTGVFEDDSLKNVA----HSGSVFGLTWSPDGTKIASASADKTIKIWNVATL 271 G +++ +S+ +A HS V LT S DGT + S + D+T++ W + + Sbjct: 317 TSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFDV 376 Query: 272 KVEKTIPVGTRIE 284 V + + TRI Sbjct: 377 SV---LNLFTRIR 386 Score = 29.3 bits (64), Expect = 4.9, Method: Compositional matrix adjust. Identities = 23/79 (29%), Positives = 41/79 (51%), Gaps = 7/79 (8%) Query: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWL-NET 593 HT +V + W+ + +LA+G DN V V+ S PI+ H ++V ++ W ++ Sbjct: 213 HTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKS--PILTFDEHK-AAVKAMAWSPHKR 269 Query: 594 TIVSAG---QDSNIKFWNV 609 +++ G D +K WNV Sbjct: 270 GVLATGGGTADRRLKIWNV 288 >5MZH-A nrPDB Length = 452 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 65/253 (25%), Positives = 108/253 (42%), Gaps = 27/253 (10%) Query: 26 NTPAGDKI------QYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTS--PSGYYCASG 77 N P GDKI + C YT G L YT HQT + S P A+G Sbjct: 145 NNPYGDKIVTGSFDKTCKLWDAYT---GQL----YYTLKGHQTEIVCLSFNPQSTIIATG 197 Query: 78 DVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTG 137 + ++WD T + T+ + + +++ I V + ++ TG Sbjct: 198 SMDNTAKLWDVE--TGQERATLAGHRAEIVSLGFNTGGDLI--VTGSFDHDSRLWDVRTG 253 Query: 138 TSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVR 197 L+G ++S F + ++SGS D T +++ + S HT V V Sbjct: 254 QCVHVLSGHRGEVSSTQFNYAGTL-VVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVA 312 Query: 198 YNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASA 257 ++ G+ S DG+ LY+ T TGV + V H G + + ++P GT++ +A Sbjct: 313 FDAAGTKMVSASADGSARLYH----TLTGVCQHTL---VGHEGEISKVAFNPQGTRLITA 365 Query: 258 SADKTIKIWNVAT 270 S+DKT ++W+ T Sbjct: 366 SSDKTCRLWDCDT 378 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 58/264 (21%), Positives = 101/264 (38%), Gaps = 40/264 (15%) Query: 136 TGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHS 195 TG L G + ++ F +I++GS D T +++ + T H + Sbjct: 125 TGEEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVC 184 Query: 196 VRYNPDGSLFASTGGDGTIVLYN------------------------GVDGTKTGVFEDD 231 + +NP ++ A+ D T L++ G D TG F+ D Sbjct: 185 LSFNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHD 244 Query: 232 S-LKNV----------AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVG 280 S L +V H G V ++ GT + S S D T ++W+V + + + V Sbjct: 245 SRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDV---RSGRCLSVK 301 Query: 281 TRIEDQQLGIIWTKQA--LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKT 338 D+ L + + +VS SA+G + G GH I+ ++ + G Sbjct: 302 QGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTR 361 Query: 339 LFSADAEGHINSWDISTGISNRVF 362 L +A ++ WD TG +V Sbjct: 362 LITASSDKTCRLWDCDTGECLQVL 385 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 46/196 (23%), Positives = 79/196 (40%), Gaps = 9/196 (4%) Query: 162 RIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYN-PDGSLFASTGGDGTIVLYNGV 220 R I+GS D T ++ + T H V+++ +N P G + D T L++ Sbjct: 108 RFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAY 167 Query: 221 DGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVG 280 G + H + L+++P T IA+ S D T K+W+V T + E+ G Sbjct: 168 TGQLYYTLK-------GHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQ-ERATLAG 219 Query: 281 TRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLF 340 R E LG +V+ S + + G V GH +++ + G + Sbjct: 220 HRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVV 279 Query: 341 SADAEGHINSWDISTG 356 S + WD+ +G Sbjct: 280 SGSIDCTSRLWDVRSG 295 Score = 36.6 bits (83), Expect = 0.031, Method: Compositional matrix adjust. Identities = 27/120 (22%), Positives = 53/120 (44%), Gaps = 4/120 (3%) Query: 490 HPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNV 549 H + ++AF+N + T K A +L +T H ++ C+S++P + Sbjct: 135 HKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYT--LKGHQTEIVCLSFNPQST 192 Query: 550 RLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 +ATGS+DN+ +W++ + + H V+ IV+ D + + W+V Sbjct: 193 IIATGSMDNTAKLWDVETGQERATL--AGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDV 250 Score = 36.6 bits (83), Expect = 0.032, Method: Compositional matrix adjust. Identities = 69/352 (19%), Positives = 127/352 (36%), Gaps = 50/352 (14%) Query: 237 AHSGSVFGLTWSPDGTKIASASADKTIKIWN------VATLKVEKTI--------PVGTR 282 AH + ++ G + + S D+T K+WN V TL+ K + P G + Sbjct: 92 AHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGDK 151 Query: 283 IEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSA 342 I V+ S + + G + GH I LS + + + Sbjct: 152 I--------------VTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATG 197 Query: 343 DAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVV--PAGGSGV 400 + WD+ TG R H I + + GDL DH + G V Sbjct: 198 SMDNTAKLWDVETG-QERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCV 256 Query: 401 DSSKAVANKLSSQPLGLAVSADGDIAVAA---CYKHIAIYSHGKLTEVPISYNSSCVALS 457 ++SS A G + V+ C + G+ V + + ++ Sbjct: 257 HVLSGHRGEVSSTQFNYA----GTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVA 312 Query: 458 NDK---QFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLV--ATDQS 512 D + V+ S + L+G V + + H EI+ VAF+ G L+ ++D++ Sbjct: 313 FDAAGTKMVSASADGSARLYHTLTG--VCQHTLVGHEGEISKVAFNPQGTRLITASSDKT 370 Query: 513 RKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWN 564 ++ ++ HT ++ +++ + + TGS DN+ +W Sbjct: 371 CRLWDCDTGECLQVLEG-----HTDEIFSCAFNYEGDFIITGSKDNTCRIWK 417 >4GGA-A nrPDB Length = 420 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 65/290 (22%), Positives = 113/290 (38%), Gaps = 66/290 (22%) Query: 71 GYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGH 130 G Y A G V++WD Q + T S V +SW+S I + G R GH Sbjct: 159 GNYLAVGTSSAEVQLWDVQQQKRLRNMT--SHSARVGSLSWNS---YILSSGS---RSGH 210 Query: 131 VFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHT 190 + D + ++ VA G H+ Sbjct: 211 IHHHDVRVA-----------------------------EHHVATLSG-----------HS 230 Query: 191 KFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKN-VAHSGSVFGLTWSP 249 + V +R+ PDG AS G D + ++ G V L+ H G+V + W P Sbjct: 231 QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV----PLQTFTQHQGAVKAVAWCP 286 Query: 250 DGTKIAS---ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGF- 305 + + + ++D+ I+IWNV + + +++ I+W+ IS +GF Sbjct: 287 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV----CSILWSPHYKELISGHGFA 342 Query: 306 ----INFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 + + P + + +++ GH + +L+ S DG T+ SA A+ + W Sbjct: 343 QNQLVIWKYPTMAKVAELK-GHTSRVLSLTMSPDGATVASAAADETLRLW 391 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 39/166 (23%), Positives = 69/166 (41%), Gaps = 7/166 (4%) Query: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTT--QTTHILKTTIPVFSGPVKDISWDSES 115 HS + + +P G + ASG V +W + + + T G VK ++W Sbjct: 229 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQ 288 Query: 116 KRIAAVGEG-RERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSD--DNTV 172 + A G G +R ++ +G + ++ S+ + P +ISG N + Sbjct: 289 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVC-SILWSPHYK-ELISGHGFAQNQL 346 Query: 173 AIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN 218 I++ P + HT V S+ +PDG+ AS D T+ L+ Sbjct: 347 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 392 Score = 38.5 bits (88), Expect = 0.009, Method: Compositional matrix adjust. Identities = 45/173 (26%), Positives = 80/173 (46%), Gaps = 15/173 (8%) Query: 444 EVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNG 503 E P Y SS VA + ++AVG ++V ++ + T H A + S+++ N Sbjct: 144 EQPGEYISS-VAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMT-SHSARVGSLSW--NS 199 Query: 504 AFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVW 563 L + +S + + V H + + H+ +V + W+PD LA+G DN V VW Sbjct: 200 YILSSGSRSGHIHHHDV--RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 257 Query: 564 NMNKPSDH---PIIIKGAHAMSSVNSVIWLN-ETTIVSAG---QDSNIKFWNV 609 + P + P+ H +V +V W ++ +++ G D +I+ WNV Sbjct: 258 P-SAPGEGGWVPLQTFTQH-QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 308 >5LCW-Q nrPDB Length = 374 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 61/290 (21%), Positives = 114/290 (39%), Gaps = 66/290 (22%) Query: 71 GYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGH 130 G Y A G V++WD Q + T S V +SW+S Sbjct: 113 GNYLAVGTSSAEVQLWDVQQQKRLRNMT--SHSARVGSLSWNS----------------- 153 Query: 131 VFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHT 190 ++ +G+ +G++ + V + E +T H+ Sbjct: 154 -YILSSGSRSGHI------------------------HHHDVRVAE----HHVATLSGHS 184 Query: 191 KFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKN-VAHSGSVFGLTWSP 249 + V +R+ PDG AS G D + ++ G V L+ H G+V + W P Sbjct: 185 QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV----PLQTFTQHQGAVKAVAWCP 240 Query: 250 DGTKIAS---ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGF- 305 + + + ++D+ I+IWNV + + +++ I+W+ IS +GF Sbjct: 241 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV----CSILWSPHYKELISGHGFA 296 Query: 306 ----INFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 + + P + + +++ GH + +L+ S DG T+ SA A+ + W Sbjct: 297 QNQLVIWKYPTMAKVAELK-GHTSRVLSLTMSPDGATVASAAADETLRLW 345 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 39/166 (23%), Positives = 69/166 (41%), Gaps = 7/166 (4%) Query: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTT--QTTHILKTTIPVFSGPVKDISWDSES 115 HS + + +P G + ASG V +W + + + T G VK ++W Sbjct: 183 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQ 242 Query: 116 KRIAAVGEG-RERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSD--DNTV 172 + A G G +R ++ +G + ++ S+ + P +ISG N + Sbjct: 243 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVC-SILWSPHYK-ELISGHGFAQNQL 300 Query: 173 AIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN 218 I++ P + HT V S+ +PDG+ AS D T+ L+ Sbjct: 301 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 346 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 45/173 (26%), Positives = 80/173 (46%), Gaps = 15/173 (8%) Query: 444 EVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNG 503 E P Y SS VA + ++AVG ++V ++ + T H A + S+++ N Sbjct: 98 EQPGEYISS-VAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMT-SHSARVGSLSW--NS 153 Query: 504 AFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVW 563 L + +S + + V H + + H+ +V + W+PD LA+G DN V VW Sbjct: 154 YILSSGSRSGHIHHHDV--RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 211 Query: 564 NMNKPSDH---PIIIKGAHAMSSVNSVIWLN-ETTIVSAG---QDSNIKFWNV 609 + P + P+ H +V +V W ++ +++ G D +I+ WNV Sbjct: 212 P-SAPGEGGWVPLQTFTQH-QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 262 >4N14-A nrPDB Length = 314 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 43/177 (24%), Positives = 82/177 (46%), Gaps = 18/177 (10%) Query: 184 STFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKN-VAHSGSV 242 +T H++ V +R+ PDG AS G D + ++ G V L+ H G+V Sbjct: 140 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV----PLQTFTQHQGAV 195 Query: 243 FGLTWSPDGTKIAS---ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVS 299 + W P + + + ++D+ I+IWNV + + +++ I+W+ Sbjct: 196 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV----CSILWSPHYKEL 251 Query: 300 ISANGF-----INFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 IS +GF + + P + + +++ GH + +L+ S DG T+ SA A+ + W Sbjct: 252 ISGHGFAQNQLVIWKYPTMAKVAELK-GHTSRVLSLTMSPDGATVASAAADETLRLW 307 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 61/247 (24%), Positives = 99/247 (40%), Gaps = 55/247 (22%) Query: 71 GYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGH 130 G Y A G V++WD Q + T S V +SW+S I + G R GH Sbjct: 75 GNYLAVGTSSAEVQLWDVQQQKRLRNMT--SHSARVGSLSWNS---YILSSG---SRSGH 126 Query: 131 VFLFDTGTSN---GNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPP----FKFK 183 + D + L+G ++ + + + P + SG +DN V ++ P + Sbjct: 127 IHHHDVRVAEHHVATLSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWPSAPGEGGWVPL 185 Query: 184 STFGEHTKFVHSVRYNPDGSLFASTGG---DGTIVLYNGVDGT----------------- 223 TF +H V +V + P S +TGG D I ++N G Sbjct: 186 QTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWS 245 Query: 224 ---------------KTGVFEDDSLKNVA----HSGSVFGLTWSPDGTKIASASADKTIK 264 + +++ ++ VA H+ V LT SPDG +ASA+AD+T++ Sbjct: 246 PHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLR 305 Query: 265 IWNVATL 271 +W L Sbjct: 306 LWRCFEL 312 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 39/166 (23%), Positives = 69/166 (41%), Gaps = 7/166 (4%) Query: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTT--QTTHILKTTIPVFSGPVKDISWDSES 115 HS + + +P G + ASG V +W + + + T G VK ++W Sbjct: 145 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQ 204 Query: 116 KRIAAVGEG-RERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSD--DNTV 172 + A G G +R ++ +G + ++ S+ + P +ISG N + Sbjct: 205 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVC-SILWSPHYK-ELISGHGFAQNQL 262 Query: 173 AIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN 218 I++ P + HT V S+ +PDG+ AS D T+ L+ Sbjct: 263 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 308 Score = 38.1 bits (87), Expect = 0.012, Method: Compositional matrix adjust. Identities = 45/173 (26%), Positives = 80/173 (46%), Gaps = 15/173 (8%) Query: 444 EVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNG 503 E P Y SS VA + ++AVG ++V ++ + T H A + S+++ N Sbjct: 60 EQPGEYISS-VAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMT-SHSARVGSLSW--NS 115 Query: 504 AFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVW 563 L + +S + + V H + + H+ +V + W+PD LA+G DN V VW Sbjct: 116 YILSSGSRSGHIHHHDV--RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 173 Query: 564 NMNKPSDH---PIIIKGAHAMSSVNSVIWLN-ETTIVSAG---QDSNIKFWNV 609 + P + P+ H +V +V W ++ +++ G D +I+ WNV Sbjct: 174 P-SAPGEGGWVPLQTFTQH-QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 224 >4V6W-Ag nrPDB Length = 318 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 65/251 (25%), Positives = 110/251 (43%), Gaps = 35/251 (13%) Query: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDI---SWDSE 114 HSH + S G Y SG +R+WD T F G KD+ ++ ++ Sbjct: 63 HSHFISDVVLSSDGNYALSGSWDQTLRLWDLAA-----GKTTRRFEGHTKDVLSVAFSAD 117 Query: 115 SKRIAAVGEGRERFGHVFLFDTGTSNGNLT----GQARAMNSVDFKP--SRPFRIISGSD 168 +++I V R++ + L++T + T G ++ V F P S P I+S Sbjct: 118 NRQI--VSGSRDKT--IKLWNT-LAECKFTIQEDGHTDWVSCVRFSPNHSNPI-IVSCGW 171 Query: 169 DNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVF 228 D TV ++ K K+ H ++++V +PDGSL S G D +L++ DG Sbjct: 172 DRTVKVWNLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGK----- 226 Query: 229 EDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT------LKVEKTIPVGTR 282 +L + H+ + L +SP+ + A +IKIW++A L+ E P Sbjct: 227 ---NLYTLEHNDIINALCFSPNRYWLCVAYG-PSIKIWDLACKKTVEELRPEVVSPTSKA 282 Query: 283 IEDQQLGIIWT 293 + Q L + W+ Sbjct: 283 DQPQCLSLAWS 293 Score = 55.8 bits (133), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 58/231 (25%), Positives = 93/231 (40%), Gaps = 29/231 (12%) Query: 141 GNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF-----EGPPFKF--KSTFGEHTKFV 193 G L G + + P P IIS S D T+ ++ E + + K +G H+ F+ Sbjct: 9 GTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYG-HSHFI 67 Query: 194 HSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTK 253 V + DG+ S D T+ L++ G T FE H+ V + +S D + Sbjct: 68 SDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFE-------GHTKDVLSVAFSADNRQ 120 Query: 254 IASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGII--------WTKQALVSISANGF 305 I S S DKTIK+WN + + TI ED + + +VS + Sbjct: 121 IVSGSRDKTIKLWNTLA-ECKFTIQ-----EDGHTDWVSCVRFSPNHSNPIIVSCGWDRT 174 Query: 306 INFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 + N + +GHN + ++ S DG S + WD++ G Sbjct: 175 VKVWNLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDG 225 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 81/357 (22%), Positives = 134/357 (37%), Gaps = 82/357 (22%) Query: 236 VAHSGSVFGLTWSP-DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK 294 + H+G V + +P D I SAS DKT+ +W + TR ED G Sbjct: 12 IGHNGWVTQIATNPKDPDTIISASRDKTLIVWKL------------TRDEDTNYGY---- 55 Query: 295 QALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIS 354 P+ + YGH+ I+ + S+DG S + + WD++ Sbjct: 56 ----------------PQ-----KRLYGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLA 94 Query: 355 TGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQP 414 G + R F + H D+ +V++ + + +G D + + N L+ Sbjct: 95 AGKTTRRF-EGHTK-----------DVLSVAFSADNRQIVSGSR--DKTIKLWNTLAE-- 138 Query: 415 LGLAVSADGDIAVAACYK------HIAIYSHGKLTEVPISYNSSC--------------- 453 + DG +C + + I S G V + ++C Sbjct: 139 CKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNHHGHNGYLNT 198 Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFL-VATDQS 512 V +S D GG+DSK ++ L+ + T+ H I ++ FS N +L VA S Sbjct: 199 VTVSPDGSLCTSGGKDSKALLWDLNDGK--NLYTLEHNDIINALCFSPNRYWLCVAYGPS 256 Query: 513 RKVIPYSVANNFELAHTN--SWTFHTAKVACVS--WSPDNVRLATGSLDNSVIVWNM 565 K+ + E S T + C+S WS D L G DN++ VW + Sbjct: 257 IKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQV 313 Score = 34.3 bits (77), Expect = 0.15, Method: Compositional matrix adjust. Identities = 31/121 (25%), Positives = 54/121 (44%), Gaps = 4/121 (3%) Query: 490 HPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNV 549 H I+ V S++G + ++ + + + +A T + HT V V++S DN Sbjct: 63 HSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAG---KTTRRFEGHTKDVLSVAFSADNR 119 Query: 550 RLATGSLDNSVIVWNMNKPSDHPIIIKG-AHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 ++ +GS D ++ +WN I G +S V + IVS G D +K WN Sbjct: 120 QIVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWN 179 Query: 609 V 609 + Sbjct: 180 L 180 Score = 33.1 bits (74), Expect = 0.39, Method: Compositional matrix adjust. Identities = 26/115 (22%), Positives = 51/115 (44%), Gaps = 5/115 (4%) Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGA--FLVATDQ 511 VA S D + + G +D + ++ ++ H ++ V FS N + +V+ Sbjct: 112 VAFSADNRQIVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGW 171 Query: 512 SRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMN 566 R V +++AN N+ H + V+ SPD +G D+ ++W++N Sbjct: 172 DRTVKVWNLAN---CKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLN 223 >1VYH-C nrPDB Length = 410 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 40/130 (30%), Positives = 62/130 (47%), Gaps = 12/130 (9%) Query: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDG 202 L+G + V F P ++S S+D T+ +++ F+ T HT V + ++ G Sbjct: 104 LSGHRSPVTRVIFHPVFSV-MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSG 162 Query: 203 SLFASTGGDGTIVLYN--GVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASAD 260 L AS D TI L++ G + +T H +V ++ P+G I SAS D Sbjct: 163 KLLASCSADMTIKLWDFQGFECIRT---------MHGHDHNVSSVSIMPNGDHIVSASRD 213 Query: 261 KTIKIWNVAT 270 KTIK+W V T Sbjct: 214 KTIKMWEVQT 223 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 62/240 (25%), Positives = 101/240 (42%), Gaps = 34/240 (14%) Query: 53 EIYTEHSHQTTVAKT--SPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDIS 110 E Y H++ V + P S +++WD T + T+ + V+DIS Sbjct: 100 EKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWD--YETGDFERTLKGHTDSVQDIS 157 Query: 111 WDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDN 170 +D K +A+ + ++ F + G ++SV P+ I+S S D Sbjct: 158 FDHSGKLLASCSA--DMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGD-HIVSASRDK 214 Query: 171 TVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFED 230 T+ ++E TF H ++V VR N DG+L AS D T+ ++ V TK E Sbjct: 215 TIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW--VVATKECKAE- 271 Query: 231 DSLKNVAHSGSVFGLTWSPD--------------------GTKIASASADKTIKIWNVAT 270 L+ H V ++W+P+ G + S S DKTIK+W+V+T Sbjct: 272 --LRE--HRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVST 327 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 67/328 (20%), Positives = 128/328 (39%), Gaps = 27/328 (8%) Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQAL 297 H V + + P + + SAS D TIK+W+ T E+T+ G Q + + + L Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLK-GHTDSVQDISFDHSGKLL 165 Query: 298 VSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGI 357 S SA+ I + + + +GH+ ++++S +G + SA + I W++ TG Sbjct: 166 ASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTGY 225 Query: 358 SNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGL 417 + F H + ++ G L +D V V ++K +L Sbjct: 226 CVKTFTG-HREWVRMVRPNQDGTLIASCSNDQTVRV-----WVVATKECKAELREHR--- 276 Query: 418 AVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKL 477 V C S+ ++E + S F+ G +D + ++ + Sbjct: 277 --------HVVECISWAPESSYSSISE---ATGSETKKSGKPGPFLLSGSRDKTIKMWDV 325 Query: 478 SGASVSEVKTIV-HPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHT 536 S + T+V H + V F + G F+++ + + + N + N+ H Sbjct: 326 STGMC--LMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNA---HE 380 Query: 537 AKVACVSWSPDNVRLATGSLDNSVIVWN 564 V + + + TGS+D +V VW Sbjct: 381 HFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 46/178 (25%), Positives = 80/178 (44%), Gaps = 10/178 (5%) Query: 178 PPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 PP K+ H V V ++P S+ S D TI +++ +TG FE +LK Sbjct: 98 PPEKY--ALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWD----YETGDFER-TLK--G 148 Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQAL 297 H+ SV +++ G +AS SAD TIK+W+ + +T+ G + I+ + Sbjct: 149 HTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMH-GHDHNVSSVSIMPNGDHI 207 Query: 298 VSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIST 355 VS S + I + G + GH + + + + DG + S + + W ++T Sbjct: 208 VSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVAT 265 Score = 38.1 bits (87), Expect = 0.010, Method: Compositional matrix adjust. Identities = 41/174 (23%), Positives = 71/174 (40%), Gaps = 22/174 (12%) Query: 121 VGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRII-SGSDDNTVAIFEGPP 179 V R++ ++ TG TG + V +P++ +I S S+D TV ++ Sbjct: 208 VSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV--RPNQDGTLIASCSNDQTVRVWVVAT 265 Query: 180 FKFKSTFGEHTKFVHSVRYNPD----------GSLFASTGGDGTIVLYNGVDGT------ 223 + K+ EH V + + P+ GS +G G +L D T Sbjct: 266 KECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV 325 Query: 224 KTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTI 277 TG+ + V H V G+ + G I S + DKT+++W+ + KT+ Sbjct: 326 STGMC---LMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTL 376 Score = 33.9 bits (76), Expect = 0.22, Method: Compositional matrix adjust. Identities = 47/240 (19%), Positives = 89/240 (37%), Gaps = 40/240 (16%) Query: 54 IYTEHSHQTTVAKTS--PSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGP---VKD 108 I T H H V+ S P+G + S +++W+ QT + +KT F+G V+ Sbjct: 185 IRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEV-QTGYCVKT----FTGHREWVRM 239 Query: 109 ISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSR--------- 159 + + + IA+ ++ V++ T L + + + P Sbjct: 240 VRPNQDGTLIASCSN--DQTVRVWVVATKECKAELREHRHVVECISWAPESSYSSISEAT 297 Query: 160 -----------PFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFAST 208 PF ++SGS D T+ +++ T H +V V ++ G S Sbjct: 298 GSETKKSGKPGPF-LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSC 356 Query: 209 GGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNV 268 D T+ +++ + AH V L + + + S D+T+K+W Sbjct: 357 ADDKTLRVWDYKNKRCMKTLN-------AHEHFVTSLDFHKTAPYVVTGSVDQTVKVWEC 409 Score = 32.0 bits (71), Expect = 0.71, Method: Compositional matrix adjust. Identities = 40/135 (29%), Positives = 57/135 (42%), Gaps = 15/135 (11%) Query: 475 YKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTF 534 Y LSG + I HP + SV S + D + KV Y + FE + Sbjct: 102 YALSGHRSPVTRVIFHP--VFSVMVS------ASEDATIKVWDYETGD-FE----RTLKG 148 Query: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT 594 HT V +S+ LA+ S D ++ +W+ + H +SSV+ I N Sbjct: 149 HTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVS--IMPNGDH 206 Query: 595 IVSAGQDSNIKFWNV 609 IVSA +D IK W V Sbjct: 207 IVSASRDKTIKMWEV 221 >5WBU-D nrPDB Length = 328 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 62/247 (25%), Positives = 101/247 (40%), Gaps = 22/247 (8%) Query: 105 PVKDISWDSESKRIAAVG---EGRERF-------GHVFLFDTGTSNGNLTGQARA-MNSV 153 P IS+D +K IA+VG +GR + ++ + Q A +N V Sbjct: 77 PNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCV 136 Query: 154 DFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGT 213 P++ +I G + I++ + E + S +PD S A+ G Sbjct: 137 CLHPNQA-ELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGN 195 Query: 214 IVLYNGVDGTKTGVFE-DDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVA--T 270 ++N G V + K AH+ +SPD T +A+ SAD+T KIW + + Sbjct: 196 CYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFS 255 Query: 271 LKVEKTIPVGTRIEDQQLGIIW------TKQALVSISANGFINFVNPELGSIDQVRYGHN 324 L E +I G E + G +W Q +V+ S++ E G I + GH Sbjct: 256 LMTELSIKSGNPGESSR-GWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQ 314 Query: 325 KAITALS 331 KA+ L+ Sbjct: 315 KAVVCLA 321 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 59/258 (22%), Positives = 89/258 (34%), Gaps = 61/258 (23%) Query: 412 SQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPI-SY-----NSSCVALSNDKQFVAV 465 SQ L V+ D + AA Y+HI +Y PI SY N + V D +++ Sbjct: 45 SQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYT 104 Query: 466 GGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQS------------- 512 GG+D ++ L ++ + A I V N A L+ DQS Sbjct: 105 GGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHN 164 Query: 513 RKVIP----------------YSVANNFELAHTNSWTF-------------------HTA 537 ++IP Y A N + W HT Sbjct: 165 EQLIPEPEVSITSAHIDPDASYMAAVN-STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTR 223 Query: 538 KVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDH-PIIIKGAHAMSSVNSVIW-----LN 591 +SPD+ LAT S D + +W + S + IK + S +W + Sbjct: 224 YALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGD 283 Query: 592 ETTIVSAGQDSNIKFWNV 609 IV+A D+ + W V Sbjct: 284 SQYIVTASSDNLARLWCV 301 Score = 31.2 bits (69), Expect = 1.3, Method: Compositional matrix adjust. Identities = 43/216 (19%), Positives = 88/216 (40%), Gaps = 12/216 (5%) Query: 158 SRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLY 217 S P + + D+TV ++ T V+++ PD S+ A+ G I +Y Sbjct: 12 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMY 70 Query: 218 NGVDGTKTGVFEDDSL-KNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT--LKVE 274 + + D + KN+A G + DG + + D T +IW++ + L+ + Sbjct: 71 DLNSNNPNPIISYDGVNKNIASVG------FHEDGRWMYTGGEDCTARIWDLRSRNLQCQ 124 Query: 275 KTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSA 334 + V I L + L+ +G I+ + + +Q+ +IT+ Sbjct: 125 RIFQVNAPINCVCLHP--NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP 182 Query: 335 DGKTLFSADAEGHINSWDISTGISNRVFPDVHATMI 370 D + + ++ G+ W+++ GI + V + T I Sbjct: 183 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKI 218 >6QX9-5O nrPDB Length = 357 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 80/382 (20%), Positives = 133/382 (34%), Gaps = 108/382 (28%) Query: 237 AHSGSVFGLTWSPDGTKIASASADKTIKIWNV-------ATLKVEKTIPVGTRIEDQQLG 289 H G V+ + P+G+ +ASA D+ I +WNV ATLK Sbjct: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLK----------------- 106 Query: 290 IIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHIN 349 GH+ A+ L + DG LFSA + + Sbjct: 107 --------------------------------GHSGAVMELHYNTDGSMLFSASTDKTVA 134 Query: 350 SWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANK 409 WD TG + H + + +G + D Sbjct: 135 VWDSETGERVKRLKG-HTSFVNSCYPARRGPQLVCTGSD--------------------- 172 Query: 410 LSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQD 469 DG + + K AI + +Y V ++ + GG D Sbjct: 173 ------------DGTVKLWDIRKKAAIQTFQN------TYQVLAVTFNDTSDQIISGGID 214 Query: 470 SKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLV--ATDQSRKV---IPYSVANN- 523 + + V+ L ++ H +T ++ S+ G++L+ A D + +V P++ Sbjct: 215 NDIKVWDLRQNKLTYTMR-GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERC 273 Query: 524 FELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSS 583 ++ N F + C SWSPD ++A GS D V VW+ + I+ K S Sbjct: 274 VKIFQGNVHNFEKNLLRC-SWSPDGSKIAAGSADRFVYVWDT---TSRRILYKLPGHAGS 329 Query: 584 VNSVIW-LNETTIVSAGQDSNI 604 +N V + +E I+SA D + Sbjct: 330 INEVAFHPDEPIIISASSDKRL 351 Score = 52.0 bits (123), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 51/209 (24%), Positives = 99/209 (47%), Gaps = 17/209 (8%) Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFED-DSLKNV-AHSGSVFGLT 246 H V+ +++P+GS AS G D I+L+N V+ D D+ + HSG+V L Sbjct: 65 HEGEVYCCKFHPNGSTLASAGFDRLILLWN--------VYGDCDNYATLKGHSGAVMELH 116 Query: 247 WSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFI 306 ++ DG+ + SAS DKT+ +W+ T + K + T + Q + + S +G + Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTV 176 Query: 307 NFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDV- 365 + + Q + + + A++ + + S + I WD+ N++ + Sbjct: 177 KLWDIRKKAAIQT-FQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLR---QNKLTYTMR 232 Query: 366 -HATMITGIKTTSKGD-LFTVSWDDHLKV 392 HA +TG+ +S+G L + + D+ ++V Sbjct: 233 GHADSVTGLSLSSEGSYLLSNAMDNTVRV 261 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 31/122 (25%), Positives = 61/122 (50%), Gaps = 9/122 (7%) Query: 162 RIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVD 221 +IISG DN + +++ K T H V + + +GS S D T+ +++ Sbjct: 207 QIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD--- 263 Query: 222 GTKTGVFEDDSLK----NVAH-SGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKT 276 + ++ +K NV + ++ +WSPDG+KIA+ SAD+ + +W+ + ++ Sbjct: 264 -VRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYK 322 Query: 277 IP 278 +P Sbjct: 323 LP 324 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/215 (22%), Positives = 91/215 (42%), Gaps = 11/215 (5%) Query: 54 IYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS 113 + + H + K P+G AS + +W+ T+ SG V ++ +++ Sbjct: 61 LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNY-ATLKGHSGAVMELHYNT 119 Query: 114 ESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVA 173 + + + ++ V+ +TG L G +NS P + +GSDD TV Sbjct: 120 DGSMLFSAST--DKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVK 177 Query: 174 IFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSL 233 +++ TF ++T V +V +N S G D I +++ T Sbjct: 178 LWDIRKKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR---- 232 Query: 234 KNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNV 268 H+ SV GL+ S +G+ + S + D T+++W+V Sbjct: 233 ---GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDV 264 Score = 42.0 bits (97), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 39/132 (29%), Positives = 57/132 (43%), Gaps = 15/132 (11%) Query: 55 YTEHSHQTTVAKTSPS--GYYCASGDVHGNVRIWDT------TQTTHILKTTIPVFSGPV 106 YT H +V S S G Y S + VR+WD + I + + F + Sbjct: 229 YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNL 288 Query: 107 KDISWDSESKRIAAVGEGRERFGHVFLFDTGTSN--GNLTGQARAMNSVDFKPSRPFRII 164 SW + +IAA +RF V+++DT + L G A ++N V F P P II Sbjct: 289 LRCSWSPDGSKIAAGSA--DRF--VYVWDTTSRRILYKLPGHAGSINEVAFHPDEPI-II 343 Query: 165 SGSDDNTVAIFE 176 S S D + + E Sbjct: 344 SASSDKRLYMGE 355 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 37/173 (21%), Positives = 72/173 (41%), Gaps = 14/173 (8%) Query: 184 STFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVF 243 +T H+ V + YN DGS+ S D T+ +++ G + + H+ V Sbjct: 103 ATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLK-------GHTSFVN 155 Query: 244 GLTWSPDGTK-IASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW--TKQALVSI 300 + G + + + S D T+K+W++ +T + Q L + + T ++S Sbjct: 156 SCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTF----QNTYQVLAVTFNDTSDQIISG 211 Query: 301 SANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 + I + + GH ++T LS S++G L S + + WD+ Sbjct: 212 GIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDV 264 Score = 35.8 bits (81), Expect = 0.055, Method: Compositional matrix adjust. Identities = 29/111 (26%), Positives = 51/111 (45%), Gaps = 15/111 (13%) Query: 163 IISGSDDNTVAIFEGPPFK--------FKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTI 214 ++S + DNTV +++ PF F+ K + ++PDGS A+ D + Sbjct: 250 LLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFV 309 Query: 215 VLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKI 265 ++ D T + K H+GS+ + + PD I SAS+DK + + Sbjct: 310 YVW---DTTSRRIL----YKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353 >3MKQ-A nrPDB Length = 814 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 67/240 (27%), Positives = 100/240 (41%), Gaps = 45/240 (18%) Query: 81 GNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSN 140 G V IW+ T + +I V PV+ + + I VG R VF ++TG Sbjct: 35 GRVEIWN--YETQVEVRSIQVTETPVRAGKFIARKNWII-VGSDDFRI-RVFNYNTGEKV 90 Query: 141 GNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPP-FKFKSTFGEHTKFVHSVRYN 199 + + S+ P++P+ ++SGSDD TV ++ + + TF H FV V +N Sbjct: 91 VDFEAHPDYIRSIAVHPTKPY-VLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFN 149 Query: 200 P-DGSLFASTGGDGTIVLY----------------NGV------------------DGTK 224 P D S FAS D T+ ++ GV D Sbjct: 150 PKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLT 209 Query: 225 TGVFEDDSLKNVA----HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVG 280 +++ + VA H +V + P I S S D T+KIWN +T KVEKT+ VG Sbjct: 210 IKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVG 269 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 39/154 (25%), Positives = 74/154 (48%), Gaps = 11/154 (7%) Query: 460 KQFVAVGGQDSKVHVYKL-SGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPY 518 K ++ VG D ++ V+ +G V + + HP I S+A ++++ V + Sbjct: 67 KNWIIVGSDDFRIRVFNYNTGEKVVDFEA--HPDYIRSIAVHPTKPYVLSGSDDLTVKLW 124 Query: 519 SVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVWNMNKPSDHPIIIKG 577 + NN+ L T + H V CV+++P D A+G LD +V VW++ + + + + G Sbjct: 125 NWENNWALEQT--FEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTG 182 Query: 578 AHAMSSVNSVIWL---NETTIVSAGQDSNIKFWN 608 VN V + ++ +++A D IK W+ Sbjct: 183 QE--RGVNYVDYYPLPDKPYMITASDDLTIKIWD 214 >4V8M-A7 nrPDB Length = 318 Score = 55.5 bits (132), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 40/124 (32%), Positives = 64/124 (51%), Gaps = 10/124 (8%) Query: 490 HPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTF--HTAKVACVSWSPD 547 H A ++ VA SNNG F V+ + +++ N + F HT V V++SPD Sbjct: 66 HSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNG-----QCQYKFLGHTKDVLSVAFSPD 120 Query: 548 NVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHA--MSSVNSVIWLNETTIVSAGQDSNIK 605 N ++ +G DN++ VWN+ H + +GAH +S V L+ IVS G D+ +K Sbjct: 121 NRQIVSGGRDNALRVWNVKGECMH-TLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVK 179 Query: 606 FWNV 609 W++ Sbjct: 180 VWDL 183 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/237 (23%), Positives = 97/237 (40%), Gaps = 36/237 (15%) Query: 141 GNLTGQARAMNSVDFK--PSRPFRIISGSDDNTVAIFEGPPFKFKS--TFG-------EH 189 G LTG + S+ P +++S S D T+ + P + S ++G H Sbjct: 7 GQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGH 66 Query: 190 TKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP 249 + FV V + +G+ S D ++ L+N +G F + H+ V + +SP Sbjct: 67 SAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKF-------LGHTKDVLSVAFSP 119 Query: 250 DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVS-------ISA 302 D +I S D +++WNV + T+ G + W S I + Sbjct: 120 DNRQIVSGGRDNALRVWNVKG-ECMHTLSRGAHTD-------WVSCVRFSPSLDAPVIVS 171 Query: 303 NGFINFV---NPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 G+ N V + G + GH +T+++ S DG S+D +G WD++ G Sbjct: 172 GGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKG 228 Score = 45.1 bits (105), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 35/121 (28%), Positives = 63/121 (52%), Gaps = 12/121 (9%) Query: 150 MNSVDFKPS--RPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFAS 207 ++ V F PS P I+SG DN V +++ + + HT +V SV +PDGSL AS Sbjct: 155 VSCVRFSPSLDAPV-IVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCAS 213 Query: 208 TGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 + DG L++ G ++L +A + + +SP+ + +A+ +K I+I++ Sbjct: 214 SDKDGVARLWDLTKG--------EALSEMAAGAPINQICFSPNRYWMCAAT-EKGIRIFD 264 Query: 268 V 268 + Sbjct: 265 L 265 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 70/336 (20%), Positives = 129/336 (38%), Gaps = 68/336 (20%) Query: 252 TKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANG------- 304 TK+ S S DKT+ W + G + D++L + V++S NG Sbjct: 29 TKVVSTSRDKTLLSWGPNPDRHSSECSYG--LPDRRLEGHSAFVSDVALSNNGNFAVSAS 86 Query: 305 ---FINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRV 361 + N + G GH K + +++ S D + + S + + W++ + + Sbjct: 87 WDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNVKGECMHTL 146 Query: 362 FPDVHATMITGIKTTSKGD---LFTVSWDDHLKVVP-AGGSGVDSSKAVANKLSSQPLGL 417 H ++ ++ + D + + WD+ +KV A G V K N ++S + Sbjct: 147 SRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTS----V 202 Query: 418 AVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKL 477 VS DG + S+DK VA ++ L Sbjct: 203 TVSPDGSLCA-----------------------------SSDKDGVA--------RLWDL 225 Query: 478 S-GASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANN---FELA--HTNS 531 + G ++SE+ A I + FS N ++ A + + + + + N ELA H S Sbjct: 226 TKGEALSEMAA---GAPINQICFSPNRYWMCAATE-KGIRIFDLENKDIIVELAPEHQGS 281 Query: 532 WTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNK 567 + ++WS D L +G DN + VW +++ Sbjct: 282 KKI-VPECVSIAWSADGSTLYSGYTDNVIRVWGVSE 316 >2YNP-A nrPDB Length = 604 Score = 55.1 bits (131), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 66/240 (27%), Positives = 101/240 (42%), Gaps = 45/240 (18%) Query: 81 GNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSN 140 G V +W+ T + +I V PV+ + + I VG R VF ++TG Sbjct: 35 GRVELWN--YETQVEVRSIQVTETPVRAGKFIARKNWII-VGSDDFRI-RVFNYNTGEKV 90 Query: 141 GNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPP-FKFKSTFGEHTKFVHSVRYN 199 + + S+ P++P+ ++SGSDD TV ++ + + TF H FV V +N Sbjct: 91 VDFEAHPDYIRSIAVHPTKPY-VLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFN 149 Query: 200 P-DGSLFASTGGDGTIVLYN----------------GV------------------DGTK 224 P D S FAS D T+ +++ GV D Sbjct: 150 PKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLT 209 Query: 225 TGVFEDDSLKNVA----HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVG 280 +++ + VA H +V + P I S S D T+KIWN +T KVEKT+ VG Sbjct: 210 IKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVG 269 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 37/152 (24%), Positives = 74/152 (48%), Gaps = 7/152 (4%) Query: 460 KQFVAVGGQDSKVHVYKL-SGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPY 518 K ++ VG D ++ V+ +G V + + HP I S+A ++++ V + Sbjct: 67 KNWIIVGSDDFRIRVFNYNTGEKVVDFEA--HPDYIRSIAVHPTKPYVLSGSDDLTVKLW 124 Query: 519 SVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVWNMNKPSDHPIIIKG 577 + NN+ L T + H V CV+++P D A+G LD +V VW++ + + + + G Sbjct: 125 NWENNWALEQT--FEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTG 182 Query: 578 -AHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 ++ V+ ++ +++A D IK W+ Sbjct: 183 QERGVNYVDYYPLPDKPYMITASDDLTIKIWD 214 >5OQL-d nrPDB Length = 446 Score = 55.1 bits (131), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 56/229 (24%), Positives = 91/229 (39%), Gaps = 22/229 (9%) Query: 43 TVPVGSLTDTEIYTEHS-HQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPV 101 T P+ + + YT S H++ + SG C +RIWD +T P Sbjct: 144 TTPIATWQEGGPYTSLSFHRSANTFAASSGQGC--------IRIWDLEHSTAGQAIQWPS 195 Query: 102 FSGPVKDISWDS-ESKRIAAVGEGRERFGHVFLFDTGTSNGNL-TGQARAMNSVDFKPSR 159 F + D+ ++ E+ I +V R + LFD T+ + T A N + F P Sbjct: 196 FVDTITDVCFNQVETSVIGSVATDRS----IILFDLRTNMPVIKTVLHFACNRIVFNPME 251 Query: 160 PFRIISGSDDNTVAIFEGPPF-KFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN 218 + S+D+ + IF+ F K + H V V ++P G S D TI L+ Sbjct: 252 AMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLWR 311 Query: 219 GVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 G V+ ++ V F W+ D I + S D +++W Sbjct: 312 RDAGHSRDVYHTKRMQRV------FRTMWTMDSKYILTGSDDGNVRLWR 354 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 32/125 (25%), Positives = 54/125 (43%), Gaps = 5/125 (4%) Query: 485 VKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSW 544 +KT++H A + F+ A +A I A NF+ A N H A V V + Sbjct: 234 IKTVLHFA-CNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKA-LNIQKGHVAAVMDVEF 291 Query: 545 SPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW-LNETTIVSAGQDSN 603 SP L +GS D ++ +W + + H + M V +W ++ I++ D N Sbjct: 292 SPTGEELVSGSYDRTIRLW--RRDAGHSRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGN 349 Query: 604 IKFWN 608 ++ W Sbjct: 350 VRLWR 354 >5WJC-A nrPDB Length = 430 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 38/133 (28%), Positives = 63/133 (47%), Gaps = 13/133 (9%) Query: 150 MNSVDFKPSRPFRIISGSDDNTVAIFE---GPPFKFKSTFGEHTKFVHSVRYNP-DGSLF 205 +N V F P + S SDD T+ I + P + H+K +++V NP + L Sbjct: 238 VNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLL 297 Query: 206 ASTGGDGTIVLYNGVDG-TKTGVFEDDSLKNVAHSGSVFGLTWSP-DGTKIASASADKTI 263 A+ D T+ L++ + + E H V+GL WSP D +AS+S D+ + Sbjct: 298 ATASADKTVALWDLRNPYQRLHTLE-------GHEDEVYGLEWSPHDEPILASSSTDRRV 350 Query: 264 KIWNVATLKVEKT 276 IW++ + E+T Sbjct: 351 CIWDLEKIGEEQT 363 Score = 51.6 bits (122), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 42/173 (24%), Positives = 83/173 (47%), Gaps = 30/173 (17%) Query: 118 IAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVD----------FKPSRPFRIISGS 167 IA +GEG G+ ++FDT + TG+A + + P+ P + +G+ Sbjct: 147 IATMGEG----GNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLCWNPNLPGNLATGA 202 Query: 168 DDNTVAIFEGPPFKFKST----------FGEHTKFVHSVRYNPD-GSLFASTGGDGTIVL 216 +D + +++ F S+ + HT V+ V+++P +L AS D T+ + Sbjct: 203 EDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQI 262 Query: 217 YNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP-DGTKIASASADKTIKIWNV 268 ++ T+ E+ AHS ++ + +P + +A+ASADKT+ +W++ Sbjct: 263 HD----TRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDL 311 >5OPT-p nrPDB Length = 318 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 92/210 (43%), Gaps = 24/210 (11%) Query: 161 FRIISGSDDNTVAIF--------EGPPFKFKSTFGE-HTKFVHSVRYNPDGSLFASTGGD 211 + +S S DNT+ + E + F E H+ FV V + +G S D Sbjct: 29 IKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALSNNGDFAVSASWD 88 Query: 212 GTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATL 271 ++ L+N +TGV + K + H+ V +T+SPD +I S D +++WNV Sbjct: 89 HSLRLWN----LQTGVCQH---KFLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNV--- 138 Query: 272 KVEKTIPVGTRIEDQQLGIIWTKQALVS--ISANGFINFV---NPELGSIDQVRYGHNKA 326 K E +G + + +L + I + G+ N V + G + GH Sbjct: 139 KGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNY 198 Query: 327 ITALSSSADGKTLFSADAEGHINSWDISTG 356 IT+++ S DG S+D +G WD++ G Sbjct: 199 ITSVTVSPDGSLCASSDKDGVARLWDLTKG 228 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 38/122 (31%), Positives = 62/122 (50%), Gaps = 6/122 (4%) Query: 490 HPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNV 549 H A ++ VA SNNG F V+ + +++ + + HT V V++SPDN Sbjct: 66 HSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTG---VCQHKFLGHTKDVLSVTFSPDNR 122 Query: 550 RLATGSLDNSVIVWNMNKPSDHPIIIKGAHA--MSSVNSVIWLNETTIVSAGQDSNIKFW 607 ++ +G DN++ VWN+ H + +GAH +S V L IVS G D+ +K W Sbjct: 123 QIVSGGRDNALRVWNVKGECLH-TLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVW 181 Query: 608 NV 609 ++ Sbjct: 182 DI 183 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 90/207 (43%), Gaps = 48/207 (23%) Query: 150 MNSVDFKPS--RPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFAS 207 ++ V F PS P I+SG DN V +++ + + HT ++ SV +PDGSL AS Sbjct: 155 VSCVRFSPSLETPL-IVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSPDGSLCAS 213 Query: 208 TGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 + DG L++ G ++L +A + + +SP+ + +A+ +K I+I++ Sbjct: 214 SDKDGVARLWDLTKG--------EALSEMAAGAPINQICFSPNRYWMCAAT-EKGIRIFD 264 Query: 268 VATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAI 327 + K + V E QQ +K+ PE SI Sbjct: 265 LEN----KDVIVELAPEAQQK----SKKT--------------PECMSI----------- 291 Query: 328 TALSSSADGKTLFSADAEGHINSWDIS 354 + SADG TL+S + I W +S Sbjct: 292 ---AWSADGNTLYSGYTDNVIRVWSVS 315 Score = 34.3 bits (77), Expect = 0.18, Method: Compositional matrix adjust. Identities = 56/281 (19%), Positives = 120/281 (42%), Gaps = 14/281 (4%) Query: 297 LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 L++ +N N E G ++ GH+ ++ ++ S +G SA + + W++ TG Sbjct: 40 LIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTG 99 Query: 357 ISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLG 416 + F +++ + + + D+ L+V G + + A+ + Sbjct: 100 VCQHKFLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNVKGECLHTLGRGAHTDWVSCVR 159 Query: 417 LAVSADGDIAVAACYKHIA----IYSHGKLTEVPISYNS-SCVALSNDKQFVAVGGQDSK 471 + S + + V+ + ++ I S LT++ N + V +S D A +D Sbjct: 160 FSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGV 219 Query: 472 VHVYKLS-GASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANN---FELA 527 ++ L+ G ++SE+ A I + FS N ++ A + + + + + N ELA Sbjct: 220 ARLWDLTKGEALSEMAA---GAPINQICFSPNRYWMCAATE-KGIRIFDLENKDVIVELA 275 Query: 528 -HTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNK 567 + T + ++WS D L +G DN + VW++++ Sbjct: 276 PEAQQKSKKTPECMSIAWSADGNTLYSGYTDNVIRVWSVSE 316 Score = 32.3 bits (72), Expect = 0.63, Method: Compositional matrix adjust. Identities = 21/55 (38%), Positives = 28/55 (50%), Gaps = 4/55 (7%) Query: 37 NGTSVYTVPVGSL-TDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQ 90 N V+ + G L TD + +T + TV SP G CAS D G R+WD T+ Sbjct: 176 NLVKVWDIASGRLLTDLKGHTNYITSVTV---SPDGSLCASSDKDGVARLWDLTK 227 >6HQA-B nrPDB Length = 722 Score = 53.1 bits (126), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 57/228 (25%), Positives = 91/228 (39%), Gaps = 57/228 (25%) Query: 185 TFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGT---------------KTGVFE 229 TF + +++N D ++ AS D I L++ +DG+ GV Sbjct: 385 TFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWS-IDGSPLRSLLKNDPYNQQNNDGVAV 443 Query: 230 DDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVE-------------KT 276 S + V HSG+V+G+ +SPD + S S DKT+++W++ T K Sbjct: 444 KGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKF 503 Query: 277 IPVGTRI---EDQQLGIIWTKQALVSISA-NGFINFVNP--------------------- 311 P+G Q +W+ + + G +N V+ Sbjct: 504 SPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARM 563 Query: 312 ---ELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 G +V GH+ AI L+ S DG+ L SA + + WDISTG Sbjct: 564 WDIARGECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTG 611 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 44/163 (26%), Positives = 71/163 (43%), Gaps = 36/163 (22%) Query: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDG 202 L G + A+ VDF P + +IS S+D TV ++ + ++ H+ V V+++P G Sbjct: 449 LVGHSGAVYGVDFSPDNRY-LISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPMG 507 Query: 203 SLFASTGGDGTIVLY---------------NGVDGTK-----TGVFEDDSLKN------- 235 FA+ D T L+ N VD + T +F S K Sbjct: 508 HYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIA 567 Query: 236 --------VAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT 270 + HSG++ L SPDG +ASA D + +W+++T Sbjct: 568 RGECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDIST 610 Score = 48.5 bits (114), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 29/126 (23%), Positives = 59/126 (46%), Gaps = 7/126 (5%) Query: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDG 202 G ++ V+F P+ + + +GS D T +++ + F H+ ++ + +PDG Sbjct: 533 FAGHLNDVDCVEFHPNSTY-LFTGSSDKTARMWDIARGECVRVFMGHSGAINCLAVSPDG 591 Query: 203 SLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKT 262 AS G D + L++ G + S++ L +S +GT + S AD + Sbjct: 592 RWLASAGEDSVVCLWDISTGRRIKAMRGHG------RSSIYSLAFSREGTVLVSTGADNS 645 Query: 263 IKIWNV 268 +++W+V Sbjct: 646 VRVWDV 651 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 29/121 (23%), Positives = 56/121 (46%), Gaps = 6/121 (4%) Query: 490 HPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNV 549 H ++ V F N +L + + +A + H+ + C++ SPD Sbjct: 536 HLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARG---ECVRVFMGHSGAINCLAVSPDGR 592 Query: 550 RLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNE-TTIVSAGQDSNIKFWN 608 LA+ D+ V +W+++ + I H SS+ S+ + E T +VS G D++++ W+ Sbjct: 593 WLASAGEDSVVCLWDIS--TGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWD 650 Query: 609 V 609 V Sbjct: 651 V 651 Score = 36.2 bits (82), Expect = 0.048, Method: Compositional matrix adjust. Identities = 32/156 (20%), Positives = 68/156 (43%), Gaps = 6/156 (3%) Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSR 513 V S D +++ +D V ++ L + V H + + V FS G + + Sbjct: 459 VDFSPDNRYLISCSEDKTVRLWSLDTYTCL-VSYKGHSSSVWDVKFSPMGHYFATASHDQ 517 Query: 514 KVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPI 573 +S + + L + H V CV + P++ L TGS D + +W++ + + Sbjct: 518 TARLWSCDHIYPL---RIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGECVRV 574 Query: 574 IIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 + + A++ + + + + SAG+DS + W++ Sbjct: 575 FMGHSGAINCL--AVSPDGRWLASAGEDSVVCLWDI 608 Score = 35.4 bits (80), Expect = 0.073, Method: Compositional matrix adjust. Identities = 29/117 (24%), Positives = 50/117 (42%), Gaps = 29/117 (24%) Query: 452 SCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQ 511 +C+ ++D VA G QDS + ++ + G+ + L+ D Sbjct: 394 TCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRS---------------------LLKND- 431 Query: 512 SRKVIPYSVANNFELAHTNSWTF--HTAKVACVSWSPDNVRLATGSLDNSVIVWNMN 566 PY+ NN +A S H+ V V +SPDN L + S D +V +W+++ Sbjct: 432 -----PYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLD 483 Score = 35.4 bits (80), Expect = 0.075, Method: Compositional matrix adjust. Identities = 65/293 (22%), Positives = 114/293 (38%), Gaps = 48/293 (16%) Query: 245 LTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANG 304 L ++ D T +AS D IK+W++ G+ + + +Q ++ G Sbjct: 396 LKFNDDSTMVASGFQDSFIKLWSID----------GSPLRSLLKNDPYNQQNNDGVAVKG 445 Query: 305 FINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPD 364 V GH+ A+ + S D + L S + + W + T + V Sbjct: 446 SRRLV------------GHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDT-YTCLVSYK 492 Query: 365 VHATMITGIKTTSKGDLF-TVSWD--------DHLKVVPAGGSGVDSSKAVANKLSSQPL 415 H++ + +K + G F T S D DH+ + ++ V +S L Sbjct: 493 GHSSSVWDVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYL 552 Query: 416 GLAVSADG-----DIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDS 470 S+D DIA C + +S G + +C+A+S D +++A G+DS Sbjct: 553 -FTGSSDKTARMWDIARGECVRVFMGHS-GAI---------NCLAVSPDGRWLASAGEDS 601 Query: 471 KVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANN 523 V ++ +S + + I S+AFS G LV+T V + V N Sbjct: 602 VVCLWDISTGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVKKN 654 >5I2T-A nrPDB Length = 742 Score = 52.8 bits (125), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 45/176 (25%), Positives = 81/176 (46%), Gaps = 9/176 (5%) Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 H +S+ Y+PDGS + DG I +++ G FE+ H+ SV + ++ Sbjct: 369 HFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEE-------HTSSVTAVQFA 421 Query: 249 PDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGF-IN 307 G + S+S D T++ W++ + +T RI+ L + + + + + S + F I+ Sbjct: 422 KRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIH 481 Query: 308 FVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFP 363 + + G + GH ++ LS S + L SA + I W I G S +V P Sbjct: 482 VWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSI-FGRSQQVEP 536 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 54/239 (22%), Positives = 101/239 (42%), Gaps = 45/239 (18%) Query: 69 PSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERF 128 P+ A G G R++D T I + ++ PV +S + + +A G + Sbjct: 295 PATRLLAVGFTSGEFRLYDLPDFTLIQQLSMG--QNPVNTVSVNQTGEWLAF---GSSKL 349 Query: 129 GHVFLFDTGTSNGNLTGQAR--AMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTF 186 G + +++ + + L Q + NS+ + P R+++ S+D + +++ +TF Sbjct: 350 GQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGS-RVVTASEDGKIKVWDITSGFCLATF 408 Query: 187 GEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN-----------GVDGTKTGVFEDD---- 231 EHT V +V++ G + S+ DGT+ ++ G + + D Sbjct: 409 EEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGE 468 Query: 232 -----SLKNV-----------------AHSGSVFGLTWSPDGTKIASASADKTIKIWNV 268 SL N H G V L++S + + +ASAS DKTI+IW++ Sbjct: 469 VVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSI 527 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 56/257 (21%), Positives = 104/257 (40%), Gaps = 57/257 (22%) Query: 233 LKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW 292 LK H S L +SPDG+++ +AS D IK+W++ + Sbjct: 364 LKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITS---------------------- 401 Query: 293 TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 GF L + ++ H ++TA+ + G+ +FS+ +G + +WD Sbjct: 402 -----------GFC------LATFEE----HTSSVTAVQFAKRGQVMFSSSLDGTVRAWD 440 Query: 353 ISTGISNRVFPDVHATMITGIKTTSKGDLFTV----SWDDHLKVVPAGGSGVDSSKAVAN 408 + + R F + G++ ++D H+ V G +D+ Sbjct: 441 LIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQT-GQLLDALSGHEG 499 Query: 409 KLSSQPLGLAVSADGDIAVAACY-KHIAIYS-HGKLTEV-PISYNSSCVALSN--DKQFV 463 +S L+ S + + +A + K I I+S G+ +V PI S +ALS D + V Sbjct: 500 PVSC----LSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEV 555 Query: 464 AVGGQDSKVHVYKLSGA 480 AV ++ ++ + A Sbjct: 556 AVSTLKGQISIFNIEDA 572 Score = 36.2 bits (82), Expect = 0.038, Method: Compositional matrix adjust. Identities = 25/77 (32%), Positives = 40/77 (51%), Gaps = 5/77 (6%) Query: 195 SVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSG---SVFGLTWSPDG 251 +V+++PDG LFA G + ++ D K F +++ H+G + LTWS D Sbjct: 126 AVKFSPDGRLFALASGR-FLQIWKTPDVNKDRQFAP-FVRHRVHAGHFQDITSLTWSQDS 183 Query: 252 TKIASASADKTIKIWNV 268 I + S D + KIW+V Sbjct: 184 RFILTTSKDLSAKIWSV 200 Score = 34.7 bits (78), Expect = 0.13, Method: Compositional matrix adjust. Identities = 91/420 (21%), Positives = 150/420 (35%), Gaps = 104/420 (24%) Query: 170 NTVAIFE---GPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTG 226 N V++F+ F F+ EH K + ++ N G+L S DG +L N Sbjct: 60 NRVSVFDLINNKSFTFEY---EHRKNIAAIDLNKQGTLLISIDEDGRAILVNF------- 109 Query: 227 VFEDDSLKNVAH----SGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTR 282 +NV H + +SPDG A AS + ++IW KT V Sbjct: 110 -----KARNVLHHFNFKEKCSAVKFSPDGRLFALASG-RFLQIW--------KTPDVN-- 153 Query: 283 IEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSA 342 +D+Q F FV +V GH + IT+L+ S D + + + Sbjct: 154 -KDRQ-----------------FAPFVR------HRVHAGHFQDITSLTWSQDSRFILTT 189 Query: 343 DAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGV-- 400 + W + + N + AT G + G F+ D K+ G Sbjct: 190 SKDLSAKIWSVDSEEKN-----LAATTFNGHRDYVMGAFFS---HDQEKIYTVSKDGAVF 241 Query: 401 --DSSKAVANKLSSQPLGLAVSADGDIAVAA---CYKHIAIYSHGKLTEVPISYNSSCVA 455 + +K ++ ++ + DI+ + KH + K+ CV Sbjct: 242 VWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKV---------KCVT 292 Query: 456 LSNDKQFVAVGGQDSKVHVYKLSGAS-VSEVKTIVHPAEITSV-------AF--SNNGAF 505 + +AVG + +Y L + + ++ +P SV AF S G Sbjct: 293 FHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQL 352 Query: 506 LVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM 565 LV QS Y + TNS +++SPD R+ T S D + VW++ Sbjct: 353 LVYEWQSE---SYILKQQGHFDSTNS----------LAYSPDGSRVVTASEDGKIKVWDI 399 Score = 30.4 bits (67), Expect = 2.2, Method: Compositional matrix adjust. Identities = 31/157 (19%), Positives = 65/157 (41%), Gaps = 44/157 (28%) Query: 451 SSCVALSNDKQFVAVGGQDSKVHVYKL-SGASVSEVKTIVHPAEITSVAFSNNGAFL--- 506 ++ +A S D V +D K+ V+ + SG ++ + H + +T+V F+ G + Sbjct: 373 TNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEE--HTSSVTAVQFAKRGQVMFSS 430 Query: 507 ------------------------------VATDQSRKVIPYSVANNFEL--------AH 528 +A D S +V+ +NF++ Sbjct: 431 SLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQL 490 Query: 529 TNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM 565 ++ + H V+C+S+S +N LA+ S D ++ +W++ Sbjct: 491 LDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSI 527 Score = 30.0 bits (66), Expect = 3.1, Method: Compositional matrix adjust. Identities = 62/294 (21%), Positives = 104/294 (35%), Gaps = 61/294 (20%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS- 113 + EH+ T + + G S + G VR WD I F+G + I ++ Sbjct: 408 FEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDL-----IRYRNFRTFTGTER-IQFNCL 461 Query: 114 ---ESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDN 170 S + G HV+ TG L+G ++ + F + S S D Sbjct: 462 AVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSV-LASASWDK 520 Query: 171 TVAIFEGPPFKFKSTFGEHTKF--------VHSVRYNPDGSLFASTGGDGTIVLYNGVDG 222 T+ I+ S FG + V ++ PDG A + G I ++N D Sbjct: 521 TIRIW--------SIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDA 572 Query: 223 TK-----------TGVFEDDSL--KNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVA 269 + +G F D KN S + +S DG I + + +I +++V Sbjct: 573 KQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVP 632 Query: 270 TLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNP----ELGSIDQV 319 + K V +++ NG + F+N E GS+D + Sbjct: 633 NEVLLKRFIVSR-----------------NMALNGTLEFLNSKKMTEAGSLDLI 669 >5WLC-LO nrPDB Length = 923 Score = 52.4 bits (124), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 45/176 (25%), Positives = 81/176 (46%), Gaps = 9/176 (5%) Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 H +S+ Y+PDGS + DG I +++ G FE+ H+ SV + ++ Sbjct: 344 HFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEE-------HTSSVTAVQFA 396 Query: 249 PDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGF-IN 307 G + S+S D T++ W++ + +T RI+ L + + + + + S + F I+ Sbjct: 397 KRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIH 456 Query: 308 FVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFP 363 + + G + GH ++ LS S + L SA + I W I G S +V P Sbjct: 457 VWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSI-FGRSQQVEP 511 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 54/239 (22%), Positives = 101/239 (42%), Gaps = 45/239 (18%) Query: 69 PSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERF 128 P+ A G G R++D T I + ++ PV +S + + +A G + Sbjct: 270 PATRLLAVGFTSGEFRLYDLPDFTLIQQLSMG--QNPVNTVSVNQTGEWLAF---GSSKL 324 Query: 129 GHVFLFDTGTSNGNLTGQAR--AMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTF 186 G + +++ + + L Q + NS+ + P R+++ S+D + +++ +TF Sbjct: 325 GQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGS-RVVTASEDGKIKVWDITSGFCLATF 383 Query: 187 GEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN-----------GVDGTKTGVFEDD---- 231 EHT V +V++ G + S+ DGT+ ++ G + + D Sbjct: 384 EEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGE 443 Query: 232 -----SLKNV-----------------AHSGSVFGLTWSPDGTKIASASADKTIKIWNV 268 SL N H G V L++S + + +ASAS DKTI+IW++ Sbjct: 444 VVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSI 502 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 56/257 (21%), Positives = 104/257 (40%), Gaps = 57/257 (22%) Query: 233 LKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW 292 LK H S L +SPDG+++ +AS D IK+W++ + Sbjct: 339 LKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITS---------------------- 376 Query: 293 TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 GF L + ++ H ++TA+ + G+ +FS+ +G + +WD Sbjct: 377 -----------GFC------LATFEE----HTSSVTAVQFAKRGQVMFSSSLDGTVRAWD 415 Query: 353 ISTGISNRVFPDVHATMITGIKTTSKGDLFTV----SWDDHLKVVPAGGSGVDSSKAVAN 408 + + R F + G++ ++D H+ V G +D+ Sbjct: 416 LIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQT-GQLLDALSGHEG 474 Query: 409 KLSSQPLGLAVSADGDIAVAACY-KHIAIYS-HGKLTEV-PISYNSSCVALSN--DKQFV 463 +S L+ S + + +A + K I I+S G+ +V PI S +ALS D + V Sbjct: 475 PVSC----LSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEV 530 Query: 464 AVGGQDSKVHVYKLSGA 480 AV ++ ++ + A Sbjct: 531 AVSTLKGQISIFNIEDA 547 Score = 36.6 bits (83), Expect = 0.034, Method: Compositional matrix adjust. Identities = 25/77 (32%), Positives = 40/77 (51%), Gaps = 5/77 (6%) Query: 195 SVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSG---SVFGLTWSPDG 251 +V+++PDG LFA G + ++ D K F +++ H+G + LTWS D Sbjct: 101 AVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAP-FVRHRVHAGHFQDITSLTWSQDS 158 Query: 252 TKIASASADKTIKIWNV 268 I + S D + KIW+V Sbjct: 159 RFILTTSKDLSAKIWSV 175 Score = 34.7 bits (78), Expect = 0.13, Method: Compositional matrix adjust. Identities = 91/417 (21%), Positives = 150/417 (35%), Gaps = 98/417 (23%) Query: 170 NTVAIFE---GPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTG 226 N V++F+ F F+ EH K + ++ N G+L S DG +L N Sbjct: 35 NRVSVFDLINNKSFTFEY---EHRKNIAAIDLNKQGTLLISIDEDGRAILVNF------- 84 Query: 227 VFEDDSLKNVAH----SGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTR 282 +NV H + +SPDG A AS + ++IW KT V Sbjct: 85 -----KARNVLHHFNFKEKCSAVKFSPDGRLFALASG-RFLQIW--------KTPDVN-- 128 Query: 283 IEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSA 342 +D+Q F FV +V GH + IT+L+ S D + + + Sbjct: 129 -KDRQ-----------------FAPFVR------HRVHAGHFQDITSLTWSQDSRFILTT 164 Query: 343 DAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGV-D 401 + W + + N + AT G + G F+ + V G V + Sbjct: 165 SKDLSAKIWSVDSEEKN-----LAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWE 219 Query: 402 SSKAVANKLSSQPLGLAVSADGDIAVAA---CYKHIAIYSHGKLTEVPISYNSSCVALSN 458 +K ++ ++ + DI+ + KH + K+ CV Sbjct: 220 FTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKV---------KCVTFHP 270 Query: 459 DKQFVAVGGQDSKVHVYKLSGAS-VSEVKTIVHPAEITSV-------AF--SNNGAFLVA 508 + +AVG + +Y L + + ++ +P SV AF S G LV Sbjct: 271 ATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVY 330 Query: 509 TDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM 565 QS Y + TNS +++SPD R+ T S D + VW++ Sbjct: 331 EWQSE---SYILKQQGHFDSTNS----------LAYSPDGSRVVTASEDGKIKVWDI 374 Score = 30.4 bits (67), Expect = 2.4, Method: Compositional matrix adjust. Identities = 31/157 (19%), Positives = 65/157 (41%), Gaps = 44/157 (28%) Query: 451 SSCVALSNDKQFVAVGGQDSKVHVYKL-SGASVSEVKTIVHPAEITSVAFSNNGAFL--- 506 ++ +A S D V +D K+ V+ + SG ++ + H + +T+V F+ G + Sbjct: 348 TNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEE--HTSSVTAVQFAKRGQVMFSS 405 Query: 507 ------------------------------VATDQSRKVIPYSVANNFEL--------AH 528 +A D S +V+ +NF++ Sbjct: 406 SLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQL 465 Query: 529 TNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM 565 ++ + H V+C+S+S +N LA+ S D ++ +W++ Sbjct: 466 LDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSI 502 Score = 29.6 bits (65), Expect = 3.5, Method: Compositional matrix adjust. Identities = 62/294 (21%), Positives = 104/294 (35%), Gaps = 61/294 (20%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS- 113 + EH+ T + + G S + G VR WD I F+G + I ++ Sbjct: 383 FEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDL-----IRYRNFRTFTGTER-IQFNCL 436 Query: 114 ---ESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDN 170 S + G HV+ TG L+G ++ + F + S S D Sbjct: 437 AVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSV-LASASWDK 495 Query: 171 TVAIFEGPPFKFKSTFGEHTKF--------VHSVRYNPDGSLFASTGGDGTIVLYNGVDG 222 T+ I+ S FG + V ++ PDG A + G I ++N D Sbjct: 496 TIRIW--------SIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDA 547 Query: 223 TK-----------TGVFEDDSL--KNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVA 269 + +G F D KN S + +S DG I + + +I +++V Sbjct: 548 KQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVP 607 Query: 270 TLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNP----ELGSIDQV 319 + K V +++ NG + F+N E GS+D + Sbjct: 608 NEVLLKRFIVSR-----------------NMALNGTLEFLNSKKMTEAGSLDLI 644 >4BTS-AR nrPDB Length = 343 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 87/213 (40%), Gaps = 34/213 (15%) Query: 163 IISGSDDNTVAIFEGPPFKFKSTFG-------EHTKFVHSVRYNPDGSLFASTGGDGTIV 215 +ISGS D TV I++ + FG H FV + + + S+ D T+ Sbjct: 42 LISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSSWDKTLR 101 Query: 216 LYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEK 275 L++ GT F V H V+ + +SPD +I SA A++ IK+WN+ + + Sbjct: 102 LWDLRTGTTYKRF-------VGHQSEVYSVAFSPDNRQILSAGAEREIKLWNI----LGE 150 Query: 276 TIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSID------------QVRY-- 321 E+ + + + + SAN F P S+ Q+RY Sbjct: 151 CKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFA-PYFASVGWDGRLKVWNTNFQIRYTF 209 Query: 322 -GHNKAITALSSSADGKTLFSADAEGHINSWDI 353 H + LS S +GK + + + + WDI Sbjct: 210 KAHESNVNHLSISPNGKYIATGGKDKKLLIWDI 242 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 61/243 (25%), Positives = 101/243 (41%), Gaps = 32/243 (13%) Query: 136 TGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFE-GPPFKFKSTFGE-HTKFV 193 TGT+ G + SV F P +I+S + + ++ KF S E H+ +V Sbjct: 107 TGTTYKRFVGHQSEVYSVAFSPDNR-QILSAGAEREIKLWNILGECKFSSAEKENHSDWV 165 Query: 194 HSVRY----------NPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVF 243 VRY P FAS G DG + ++N T + K AH +V Sbjct: 166 SCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWN------TNFQIRYTFK--AHESNVN 217 Query: 244 GLTWSPDGTKIASASADKTIKIWNVATLKV-EKTIPVGTRIED------QQLGIIWTKQA 296 L+ SP+G IA+ DK + IW++ L ++ G+ I Q + T Q Sbjct: 218 HLSISPNGKYIATGGKDKKLLIWDILNLTYPQREFDAGSTINQIAFNPKLQWVAVGTDQG 277 Query: 297 L----VSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 + + + + + E + + + G N T+L+ +A GK LF+ +G I ++ Sbjct: 278 VKIFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFAGFTDGVIRTFS 337 Query: 353 IST 355 T Sbjct: 338 FET 340 Score = 35.4 bits (80), Expect = 0.075, Method: Compositional matrix adjust. Identities = 68/311 (21%), Positives = 119/311 (38%), Gaps = 65/311 (20%) Query: 195 SVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKI 254 S + N D + S D T++++ + + G F H+ V L S + Sbjct: 32 SQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFA 91 Query: 255 ASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELG 314 S+S DKT+++W++ T GT + FV Sbjct: 92 ISSSWDKTLRLWDLRT---------GTT----------------------YKRFV----- 115 Query: 315 SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGIS-NRVFPDVHATMITGI 373 GH + +++ S D + + SA AE I W+I + + H+ ++ + Sbjct: 116 -------GHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCV 168 Query: 374 ------KTTSKGDLF-----TVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSAD 422 K+ +K F +V WD LKV + KA + ++ L++S + Sbjct: 169 RYSPIMKSANKVQPFAPYFASVGWDGRLKVWNTNFQIRYTFKAHESNVNH----LSISPN 224 Query: 423 GD-IAVAACYKHIAIYSHGKLTEVPISYNSSC----VALSNDKQFVAVGGQDSKVHVYKL 477 G IA K + I+ LT +++ +A + Q+VAV G D V ++ L Sbjct: 225 GKYIATGGKDKKLLIWDILNLTYPQREFDAGSTINQIAFNPKLQWVAV-GTDQGVKIFNL 283 Query: 478 SGASVSEVKTI 488 S + V TI Sbjct: 284 MTQSKAPVCTI 294 Score = 34.7 bits (78), Expect = 0.13, Method: Compositional matrix adjust. Identities = 35/171 (20%), Positives = 75/171 (43%), Gaps = 26/171 (15%) Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSG-ASVSEVKTIVHPAEITSVAFSNNGAFLVATDQS 512 VA S D + + G + ++ ++ + G S + H ++ V +S + + ++ Sbjct: 124 VAFSPDNRQILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYS---PIMKSANKV 180 Query: 513 RKVIPYSVA-----------NNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVI 561 + PY + NF++ +T + H + V +S SP+ +ATG D ++ Sbjct: 181 QPFAPYFASVGWDGRLKVWNTNFQIRYT--FKAHESNVNHLSISPNGKYIATGGKDKKLL 238 Query: 562 VW---NMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 +W N+ P + A S++N + + + V+ G D +K +N+ Sbjct: 239 IWDILNLTYPQ------REFDAGSTINQIAFNPKLQWVAVGTDQGVKIFNL 283 Score = 33.1 bits (74), Expect = 0.35, Method: Compositional matrix adjust. Identities = 35/174 (20%), Positives = 69/174 (39%), Gaps = 25/174 (14%) Query: 457 SNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAE------ITSVAFSNNGAFLVAT- 509 + D + G +D V ++KL + I H A ++ +A S F +++ Sbjct: 36 NEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSS 95 Query: 510 -DQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM--- 565 D++ ++ ++ + H ++V V++SPDN ++ + + + +WN+ Sbjct: 96 WDKTLRLWDLRTGTTYK-----RFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGE 150 Query: 566 --------NKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNVPF 611 SD ++ + M S N V S G D +K WN F Sbjct: 151 CKFSSAEKENHSDWVSCVRYSPIMKSANKVQPF-APYFASVGWDGRLKVWNTNF 203 >5WYK-BB nrPDB Length = 943 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 44/190 (23%), Positives = 85/190 (44%), Gaps = 18/190 (9%) Query: 436 IYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEIT 495 I +H + Y +C L V +G ++ ++ ++ L+ +S+ + H A I Sbjct: 419 IKTHKCIRTFECGYALTCKFLPGG-LLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIW 477 Query: 496 SVAFSNNGAFLV--ATDQSRKVIPYSVANNF------------ELAHTNSWTFHTAKVAC 541 S+ +++G LV + D++ K + V N+ +L H + T + C Sbjct: 478 SLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLEL-TDDILC 536 Query: 542 VSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQD 601 V SPD+ LA LDN+V V+ ++ + + H + ++ I + I+++ D Sbjct: 537 VRVSPDDRYLAISLLDNTVKVFFLDSMKFYLSLY--GHKLPVLSIDISFDSKMIITSSAD 594 Query: 602 SNIKFWNVPF 611 NIK W + F Sbjct: 595 KNIKIWGLDF 604 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 87/377 (23%), Positives = 146/377 (38%), Gaps = 70/377 (18%) Query: 127 RFGHVFLFDTGTSNGNLT---GQARAMNSVDFKPSRPFRIISGSDDNTVAIFE------- 176 R G + LFD +S+ T A+ S+D S R+++GS D TV ++ Sbjct: 450 RNGELQLFDLASSSLLDTIEDAHDAAIWSLDL-TSDGKRLVTGSADKTVKFWDFKVENSL 508 Query: 177 --GPPFKFKSTFGEH-------TKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGV 227 G KF H T + VR +PD A + D T+ V Sbjct: 509 VPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTV-----------KV 557 Query: 228 FEDDSLKNV----AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRI 283 F DS+K H V + S D I ++SADK IKIW + K++ Sbjct: 558 FFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAH--- 614 Query: 284 EDQQLGIIWTKQA--LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFS 341 +D + + + Q+ S S + + + + E Q Y H + AL+ + DG + S Sbjct: 615 QDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWALAVATDGGFVVS 674 Query: 342 ADAEGHINSWDISTGISNRVF----------PDVHATMITGIKTTSKGDLFTVSWDDHLK 391 + + I W+ + ++VF T++T ++ + D F Sbjct: 675 SSHDHSIRIWEET---EDQVFLEEEKEKELEEQYEDTLLTSLEEGNGDDAFKAD------ 725 Query: 392 VVPAGGSGVDSSKAVANK--LSSQPLGLAVSADGDIAVA------ACYKHIAIYSHGKLT 443 A G GV+ + +K L S G + D+ +A A + + ++ KL Sbjct: 726 ---ASGEGVEDEASGVHKQTLESLKAGERLMEALDLGIAEIEGLEAYNRDMKLWQRKKLG 782 Query: 444 EVPISYNSSCVALSNDK 460 E PI + V ++ +K Sbjct: 783 EAPIKPQGNAVLIAVNK 799 Score = 48.5 bits (114), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 66/313 (21%), Positives = 135/313 (43%), Gaps = 40/313 (12%) Query: 142 NLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPD 201 L GQ + S+D S ++++ + + ++ I+ K TF + + ++ P Sbjct: 386 ELQGQRTDVRSIDI--SDDNKLLATASNGSLKIWNIKTHKCIRTF--ECGYALTCKFLPG 441 Query: 202 GSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADK 261 G L +G + L++ + ED AH +++ L + DG ++ + SADK Sbjct: 442 GLLVILGTRNGELQLFDLASSSLLDTIED------AHDAAIWSLDLTSDGKRLVTGSADK 495 Query: 262 TIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQ-ALVSISANGFINFVNPE-------- 312 T+K W+ KVE ++ GT+ ++ L ++ + ++ + V+P+ Sbjct: 496 TVKFWD---FKVENSLVPGTK--NKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISL 550 Query: 313 ------LGSIDQVR-----YGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRV 361 + +D ++ YGH + ++ S D K + ++ A+ +I W + G ++ Sbjct: 551 LDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKS 610 Query: 362 FPDVHATMITGIKTTSKG-DLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVS 420 H I +K + + F+ S D +K G K A++ S+ LAV+ Sbjct: 611 LF-AHQDSIMNVKFLPQSHNFFSCSKDAVVKYWD-GEKFECIQKLYAHQ--SEVWALAVA 666 Query: 421 ADGDIAVAACYKH 433 DG V++ + H Sbjct: 667 TDGGFVVSSSHDH 679 Score = 30.0 bits (66), Expect = 2.9, Method: Compositional matrix adjust. Identities = 20/79 (25%), Positives = 36/79 (45%), Gaps = 11/79 (13%) Query: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVI---WLN 591 H A + + + RL +GS D+++IVW++ G + + S I W Sbjct: 120 HKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEV-------GLYKLRSHKDSITGFWCQ 172 Query: 592 -ETTIVSAGQDSNIKFWNV 609 E ++S +D IK W++ Sbjct: 173 GEDWLISTSKDGMIKLWDL 191 Score = 29.6 bits (65), Expect = 4.3, Method: Compositional matrix adjust. Identities = 34/161 (21%), Positives = 61/161 (37%), Gaps = 11/161 (6%) Query: 451 SSCVALS--NDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVA 508 + C L D +AVG D + V+ L +V + H A IT + F G L++ Sbjct: 80 AECTYLEAHKDTDLLAVGYADGVIKVWDLMSKTVL-LNFNGHKAAITLLQFDGTGTRLIS 138 Query: 509 TDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKP 568 + +I + + L S H + W L + S D + +W++ Sbjct: 139 GSKDSNIIVWDLVGEVGLYKLRS---HKDSITGF-WCQGEDWLISTSKDGMIKLWDLK-- 192 Query: 569 SDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 + I AH + + +++ G DS +K W + Sbjct: 193 THQCIETHIAHTGECWGLAV--KDDLLITTGTDSQVKIWKL 231 >3C9C-A nrPDB Length = 432 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 51/226 (22%), Positives = 106/226 (46%), Gaps = 36/226 (15%) Query: 70 SGYYCASGDVHGNVRIWD--TTQTTHILKTTIPVFSGP---VKDISWDSESKRI-AAVGE 123 +GY ++ D H + +WD T H + +F+G V+D++W + + +V + Sbjct: 196 NGYLLSASDDH-TICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVAD 254 Query: 124 GRERFGHVFLFDTGTSNGN-----LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP 178 ++ + ++DT +N + + +N + F P F + +GS D TVA+++ Sbjct: 255 DQK----LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 310 Query: 179 PFKFK-STFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV 236 K K +F H + V+++P + ++ AS+G D + ++ D +K G E+ S ++ Sbjct: 311 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVW---DLSKIG--EEQSTEDA 365 Query: 237 ------------AHSGSVFGLTWSPDGTK-IASASADKTIKIWNVA 269 H+ + +W+P+ I S S D +++W +A Sbjct: 366 EDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMA 411 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 37/141 (26%), Positives = 67/141 (47%), Gaps = 13/141 (9%) Query: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF-------EGPPFKFKSTFGEHTKFVHS 195 L G + + + P+ ++S SDD+T+ ++ E K+ F HT V Sbjct: 179 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 238 Query: 196 VRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKI 254 V ++ SLF S D +++++ T+ S AH+ V L+++P I Sbjct: 239 VAWHLLHESLFGSVADDQKLMIWD----TRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI 294 Query: 255 -ASASADKTIKIWNVATLKVE 274 A+ SADKT+ +W++ LK++ Sbjct: 295 LATGSADKTVALWDLRNLKLK 315 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 33/110 (30%), Positives = 55/110 (50%), Gaps = 15/110 (13%) Query: 507 VATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVWNM 565 VA DQ K++ + NN +++ HTA+V C+S++P LATGS D +V +W++ Sbjct: 252 VADDQ--KLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL 309 Query: 566 NKPSDHPIIIKGAHAMSS----VNSVIW--LNETTIVSAGQDSNIKFWNV 609 + H+ S + V W NET + S+G D + W++ Sbjct: 310 RN------LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 353 Score = 29.3 bits (64), Expect = 4.6, Method: Compositional matrix adjust. Identities = 31/128 (24%), Positives = 56/128 (43%), Gaps = 14/128 (10%) Query: 452 SCVALSNDKQFV-AVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFS-NNGAFLVAT 509 +C++ + +F+ A G D V ++ L + H EI V +S +N L ++ Sbjct: 283 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 342 Query: 510 DQSRKVIPYSVANNFELAHTN-------SWTF----HTAKVACVSWSPDNVR-LATGSLD 557 R++ + ++ E T F HTAK++ SW+P+ + + S D Sbjct: 343 GTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSED 402 Query: 558 NSVIVWNM 565 N + VW M Sbjct: 403 NIMQVWQM 410 >6J6H-n nrPDB Length = 455 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 64/308 (20%), Positives = 125/308 (40%), Gaps = 65/308 (21%) Query: 142 NLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFE-GPPFKFKSTFGEHTKFVHSVRYNP 200 N G ++ F P I+SG +D+T+ I++ ++ F H K + ++R+ Sbjct: 157 NYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTE 216 Query: 201 DGSLFASTGGDGTIVLYN-------------------------------GVDGTKTGVFE 229 D F S+ D ++ +++ G+ +K ++ Sbjct: 217 DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYD 276 Query: 230 DDSLKNVA-------HSGSVFGLTWSPDGTKIASASADKTIKIW----NVATLKVEKTIP 278 D +N H S+ L + PDG+K S+S DKT++IW NV ++ T Sbjct: 277 DRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQ 336 Query: 279 VGTRIEDQQLGIIWTKQALVSISANGFI-NF-VNPELGS-IDQVRYGHNKA--ITALSSS 333 L + ++ + S + I +F + P+ ++ GH+ A +L+ S Sbjct: 337 HSMPF----LNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFS 392 Query: 334 ADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSW--DDHLK 391 DG+ + S D++ + +WD +T + ++ IK + V W + K Sbjct: 393 GDGRYICSGDSKSRLFTWDWNT-----------SRLLNNIKIPGNKPITQVDWHPQETSK 441 Query: 392 VVPAGGSG 399 V+ +G +G Sbjct: 442 VICSGAAG 449 Score = 37.7 bits (86), Expect = 0.016, Method: Compositional matrix adjust. Identities = 38/179 (21%), Positives = 79/179 (44%), Gaps = 13/179 (7%) Query: 179 PFKFKSTFGEHTKFVHSVRYNPD-GSLFASTGGDGTIVLYNGVDGTKTGVFED-DSLKNV 236 P K + H + ++++ P G L S G D TI +++ + D + L++ Sbjct: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWD--------FYHDYECLRDF 202 Query: 237 -AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQ 295 H+ + L ++ D S+S D+++KIW+ T KV+ + + + D + + Sbjct: 203 QGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE 262 Query: 296 ALVSISANGFINFVN--PELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 +V +S + +++ + E + Q H +I AL DG S+ + + W+ Sbjct: 263 FIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 Score = 30.0 bits (66), Expect = 3.4, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 44/94 (46%), Gaps = 10/94 (10%) Query: 476 KLSGASVSEVKTIVH----PAEITSVAFSNNGAFLVATDQSRKVIPYS--VANNFELAHT 529 K+ +VKT +H PA++ S +N F+V S K++ Y V+ N L T Sbjct: 231 KIWDTETGKVKTRLHLNSTPADVESRP-TNPHEFIVGLSNS-KILHYDDRVSENQGLVQT 288 Query: 530 NSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVW 563 + H + + + + PD + + S D +V +W Sbjct: 289 --YDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 >5Z56-q nrPDB Length = 504 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 51/216 (23%), Positives = 94/216 (43%), Gaps = 34/216 (15%) Query: 152 SVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGD 211 ++D PS +I++G D V +F+ + +T HTK V SV ++P L S D Sbjct: 226 ALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPD 285 Query: 212 GTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATL 271 TI +++ + + V AH +V GL+ G + S+S D + W + + Sbjct: 286 ATIRIWSVPNASCVQVVR-------AHESAVTGLSLHATGDYLLSSSDD---QYWAFSDI 335 Query: 272 KVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSID-QVRY--------- 321 + + + T++ D+ G T +G I G++D Q++ Sbjct: 336 QTGRVL---TKVTDETSGCSLT---CAQFHPDGLIFGT----GTMDSQIKIWDLKERTNV 385 Query: 322 ----GHNKAITALSSSADGKTLFSADAEGHINSWDI 353 GH+ IT+++ S +G L +A + + WD+ Sbjct: 386 ANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDL 421 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 24/92 (26%), Positives = 48/92 (52%), Gaps = 7/92 (7%) Query: 197 RYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIAS 256 +++PDG +F + D I +++ + T F HSG + + +S +G +A+ Sbjct: 357 QFHPDGLIFGTGTMDSQIKIWDLKERTNVANFP-------GHSGPITSIAFSENGYYLAT 409 Query: 257 ASADKTIKIWNVATLKVEKTIPVGTRIEDQQL 288 A+ D ++K+W++ LK KT+ + E + L Sbjct: 410 AADDSSVKLWDLRKLKNFKTLQLDNNFEVKSL 441 Score = 37.0 bits (84), Expect = 0.023, Method: Compositional matrix adjust. Identities = 37/159 (23%), Positives = 63/159 (39%), Gaps = 12/159 (7%) Query: 63 TVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVG 122 T A+ P G +G + ++IWD + T++ P SGP+ I++ +A Sbjct: 354 TCAQFHPDGLIFGTGTMDSQIKIWDLKERTNV--ANFPGHSGPITSIAFSENGYYLATAA 411 Query: 123 EGRERFGHVFLFDTGTSNGNLTGQAR---AMNSVDFKPSRPFRIISGSDDNTVAIFEGPP 179 + V L+D T Q + S+ F S + + G+D V I+ Sbjct: 412 DD----SSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD---VQIYICKQ 464 Query: 180 FKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN 218 + F EH+ V + ASTG D ++ Y+ Sbjct: 465 WTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYS 503 Score = 35.8 bits (81), Expect = 0.055, Method: Compositional matrix adjust. Identities = 73/303 (24%), Positives = 134/303 (44%), Gaps = 35/303 (11%) Query: 238 HSGSVFG---LTWSP-DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW- 292 HS S+ G L P D KI + ADK + +++ ++ ++ T+ T+ + +++ Sbjct: 217 HSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTK---KVTSVVFH 273 Query: 293 -TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 ++ + S S + I + S QV H A+T LS A G L S+ + + Sbjct: 274 PSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFS 333 Query: 352 DISTG-ISNRVFPDVHATMITGIKTTSKGDLF-TVSWDDHLKVVPAGGSGVDSSKAVAN- 408 DI TG + +V + +T + G +F T + D +K+ + VAN Sbjct: 334 DIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIW-----DLKERTNVANF 388 Query: 409 KLSSQPL-GLAVSADG-DIAVAACYKHIAIYSHGKLTE---VPISYNSSCVALSNDKQ-- 461 S P+ +A S +G +A AA + ++ KL + + N +L D+ Sbjct: 389 PGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGT 448 Query: 462 FVAVGGQDSKVHVYKLSGASVSEVKTIVHPAE----ITSVAFSNNGAFLVATDQSRKVIP 517 ++A+GG D ++++ K + I+H E T VAF ++ F+ +T R + Sbjct: 449 YLALGGTDVQIYICK-------QWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKF 501 Query: 518 YSV 520 YS+ Sbjct: 502 YSL 504 Score = 33.1 bits (74), Expect = 0.32, Method: Compositional matrix adjust. Identities = 26/156 (16%), Positives = 65/156 (41%), Gaps = 4/156 (2%) Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSR 513 V + V D+ + ++ + AS +V H + +T ++ G +L+++ + Sbjct: 270 VVFHPSQDLVFSASPDATIRIWSVPNASCVQV-VRAHESAVTGLSLHATGDYLLSSSDDQ 328 Query: 514 KVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPI 573 + L T + C + PD + TG++D+ + +W++ + ++ + Sbjct: 329 YWAFSDIQTGRVLTKVTDET-SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN--V 385 Query: 574 IIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 H+ + N + +A DS++K W++ Sbjct: 386 ANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDL 421 Score = 30.0 bits (66), Expect = 2.8, Method: Compositional matrix adjust. Identities = 17/64 (26%), Positives = 32/64 (50%), Gaps = 2/64 (3%) Query: 547 DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKF 606 D ++ TG D +V+V++ K S+ + H + V ++ + SA D+ I+ Sbjct: 233 DTNKILTGGADKNVVVFD--KSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRI 290 Query: 607 WNVP 610 W+VP Sbjct: 291 WSVP 294 >6Q8F-A nrPDB Length = 514 Score = 48.9 bits (115), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 43/203 (21%), Positives = 81/203 (39%), Gaps = 6/203 (2%) Query: 181 KFKSTFGEHTKF-----VHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKN 235 KF + H KF V R++PDG + DG I ++N G + + N Sbjct: 201 KFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDN 260 Query: 236 -VAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK 294 + +V + +S D +A+ + D IK+W + + + + L Sbjct: 261 FMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDS 320 Query: 295 QALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIS 354 ++S S + I + G + GH+ + + + DG + SA ++G + W++ Sbjct: 321 SQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMK 380 Query: 355 TGISNRVFPDVHATMITGIKTTS 377 T + F + +T T I S Sbjct: 381 TTECSNTFKSLGSTAGTDITVNS 403 Score = 42.0 bits (97), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 24/114 (21%), Positives = 53/114 (46%), Gaps = 3/114 (2%) Query: 453 CVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQS 512 C+ S D + +A G QD K+ V+K+ H +T ++FS + + +++ Sbjct: 270 CMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFD 329 Query: 513 RKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMN 566 + + + + + L + H++ V +++ D + + S D +V +WNM Sbjct: 330 QTIRIHGLKSGKTL---KEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMK 380 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 38/179 (21%), Positives = 70/179 (39%), Gaps = 39/179 (21%) Query: 452 SCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAE---------ITSVAFSNN 502 C S D Q++ G D + V+ + + K + + A+ + + FS + Sbjct: 219 ECARFSPDGQYLVTGSVDGFIEVWNFTTGKIR--KDLKYQAQDNFMMMDDAVLCMCFSRD 276 Query: 503 GAFLVATDQSRKVIPYSVA-----NNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLD 557 L Q K+ + + FE AH+ V C+S+S D+ ++ + S D Sbjct: 277 TEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKG-------VTCLSFSKDSSQILSASFD 329 Query: 558 NSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT-------IVSAGQDSNIKFWNV 609 ++ + + +K SS ++NE T I+SA D +K WN+ Sbjct: 330 QTIRIHGLKSGK----TLKEFRGHSS-----FVNEATFTQDGHYIISASSDGTVKIWNM 379 Score = 35.8 bits (81), Expect = 0.052, Method: Compositional matrix adjust. Identities = 36/172 (20%), Positives = 70/172 (40%), Gaps = 13/172 (7%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTT------QTTHILKTTIPVFSGPVKD 108 + + SH A+ SP G Y +G V G + +W+ T + + + V Sbjct: 212 FGQKSH-VECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLC 270 Query: 109 ISWDSESKRIA-AVGEGRERFGHVFLFDTGTSNGNLT-GQARAMNSVDFKPSRPFRIISG 166 + + +++ +A +G+ + V+ +G ++ + + F +I+S Sbjct: 271 MCFSRDTEMLATGAQDGKIK---VWKIQSGQCLRRFERAHSKGVTCLSFSKDSS-QILSA 326 Query: 167 SDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN 218 S D T+ I K F H+ FV+ + DG S DGT+ ++N Sbjct: 327 SFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 378 Score = 35.4 bits (80), Expect = 0.066, Method: Compositional matrix adjust. Identities = 23/82 (28%), Positives = 38/82 (46%), Gaps = 16/82 (19%) Query: 539 VACVSWSPDNVRLATGSLDNSVIVWNMN----------KPSDHPIIIKGAHAMSSVNSVI 588 V C +SPD L TGS+D + VWN + D+ +++ A V + Sbjct: 218 VECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDA-----VLCMC 272 Query: 589 WLNETTIVSAG-QDSNIKFWNV 609 + +T +++ G QD IK W + Sbjct: 273 FSRDTEMLATGAQDGKIKVWKI 294 Score = 34.3 bits (77), Expect = 0.18, Method: Compositional matrix adjust. Identities = 35/136 (25%), Positives = 50/136 (36%), Gaps = 11/136 (8%) Query: 135 DTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAI--FEGPPFK-FKSTFGEHTK 191 +T S G+ G +NSV P P + + NTV I +G + F S E Sbjct: 386 NTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGD 445 Query: 192 FVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG 251 FV +P G G D + ++ V G H V G+ P Sbjct: 446 FV-CCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTL-------TVHEKDVIGIAHHPHQ 497 Query: 252 TKIASASADKTIKIWN 267 IA+ S D +K+W Sbjct: 498 NLIATYSEDGLLKLWK 513 >3JB9-L nrPDB Length = 340 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 71/306 (23%), Positives = 130/306 (42%), Gaps = 42/306 (13%) Query: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDT---TQTTHILKTTIPVFSGPVKDISWDSE 114 H+ + VA+ PSG Y ASG + + +W+ + +L G + D+ W + Sbjct: 49 HTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGC----KGAITDLQWSRD 104 Query: 115 SKRIAAVGEGRERFGHVFLFD--TGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTV 172 S+ + H+ +D +G G A +N++D + S SDD T+ Sbjct: 105 SRVVYCSSSDT----HLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTM 160 Query: 173 AIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDS 232 +++ T E +V G+ G DG I +++ + + V + Sbjct: 161 KVWDSRSKDCIKTIEEKYPLT-AVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLK--- 216 Query: 233 LKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNV---ATLKVEKTIPVGTRIEDQQ-- 287 H + L S DG+ + S S D T++I++V A+ + + I G I Q+ Sbjct: 217 ----GHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGA-IHGQEHN 271 Query: 288 -LGIIWTKQA-----------LVSISANGFINFVNP-ELGSIDQVRYGHNKAITALSSSA 334 LG+ W++ + + SA G + +V P GS++ V + ++ I LS S+ Sbjct: 272 LLGVAWSRNSRFVGAGSSDKNVYVWSATGDLRYVLPGHEGSVNHVDFHPHQDII-LSCSS 330 Query: 335 DGKTLF 340 D +T+F Sbjct: 331 D-RTIF 335 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 66/258 (25%), Positives = 103/258 (39%), Gaps = 60/258 (23%) Query: 186 FGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV----AHSGS 241 FG HT V R++P GS FAS G D I+L+N VF D +KN G+ Sbjct: 47 FG-HTAEVLVARFDPSGSYFASGGMDRQILLWN--------VFGD--VKNYGVLNGCKGA 95 Query: 242 VFGLTWSPDGTKIASASADKTIKIWN-VATLKVEK------------TIPVG----TRIE 284 + L WS D + +S+D + W+ V+ K+ K + VG T + Sbjct: 96 ITDLQWSRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVS 155 Query: 285 DQQLGIIWTKQA--------------LVSISANGFINFVNPELGSID----------QVR 320 D +W ++ V+I+ G F+ G+I V Sbjct: 156 DDCTMKVWDSRSKDCIKTIEEKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVL 215 Query: 321 YGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGD 380 GH IT+L+ S DG +L S + + +D+ S + + I G + + Sbjct: 216 KGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHG----QEHN 271 Query: 381 LFTVSWDDHLKVVPAGGS 398 L V+W + + V AG S Sbjct: 272 LLGVAWSRNSRFVGAGSS 289 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 68/338 (20%), Positives = 109/338 (32%), Gaps = 90/338 (26%) Query: 232 SLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGII 291 +L+ H+ V + P G+ AS D+ I +WNV Sbjct: 43 NLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNV----------------------- 79 Query: 292 WTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 + G +N G AIT L S D + ++ + ++ H+ SW Sbjct: 80 -----FGDVKNYGVLN--------------GCKGAITDLQWSRDSRVVYCSSSDTHLMSW 120 Query: 352 DISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLS 411 D +G R HA ++ + G S D + D K + K Sbjct: 121 DAVSGQKIRKHKG-HAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIEEK-- 177 Query: 412 SQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSK 471 Y + VA++ V +GG D Sbjct: 178 -------------------------------------YPLTAVAIAQQGTQVFIGGIDGA 200 Query: 472 VHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNS 531 + ++ L S V H ITS+A S +G+ L++ V + V F A Sbjct: 201 IKIWDLRNNHCSHVLK-GHKDIITSLAISKDGSSLLSNSMDNTVRIFDV-KPFASAQRQL 258 Query: 532 WTFHTA------KVACVSWSPDNVRLATGSLDNSVIVW 563 F A + V+WS ++ + GS D +V VW Sbjct: 259 QIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVW 296 Score = 30.0 bits (66), Expect = 2.8, Method: Compositional matrix adjust. Identities = 15/75 (20%), Positives = 37/75 (49%), Gaps = 3/75 (4%) Query: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT 594 HTA+V + P A+G +D +++WN+ + ++ G ++ + W ++ Sbjct: 49 HTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKG--AITDLQWSRDSR 106 Query: 595 IV-SAGQDSNIKFWN 608 +V + D+++ W+ Sbjct: 107 VVYCSSSDTHLMSWD 121 >4V7E-Bg nrPDB Length = 380 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 72/330 (21%), Positives = 133/330 (40%), Gaps = 53/330 (16%) Query: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWD--TTQTTHILKTTIPVFSGPVKDISWDSES 115 HS + +P + S G + +W+ T+Q TH +K P V + ++ Sbjct: 65 HSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPW----VMECAFAPNG 120 Query: 116 KRIAAVGEGRERFGHVF-LFDTGTSNGN------LTGQARAMNSVDFKPSRPFRIISGSD 168 + +A G + +F L +GN LTG +S + P + R+I+GS Sbjct: 121 QSVAC--GGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSG 178 Query: 169 DNTVAIFEGPPFKFKSTFGE-----HTKFVHSVRYNP-DGSLFASTGGDGTIVLYN-GVD 221 D T +++ + S FG HT V S+ N + ++F S D T+ L++ + Sbjct: 179 DQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRIT 238 Query: 222 GTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT---LKVEKTIP 278 + H G + + + PDG + + S D T +++++ T L+V P Sbjct: 239 SRAVRTYH-------GHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREP 291 Query: 279 VGTRIEDQQLGIIWTKQALVSISANGFINFVNPELG--------------SIDQVRYGHN 324 D +L I+ + V+ S +G + F G ++ ++ H Sbjct: 292 ---DRNDNELPIVTS----VAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHE 344 Query: 325 KAITALSSSADGKTLFSADAEGHINSWDIS 354 I+ L S+DG L + + ++ W S Sbjct: 345 GRISCLGLSSDGSALCTGSWDKNLKIWAFS 374 Score = 42.0 bits (97), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 77/340 (22%), Positives = 123/340 (36%), Gaps = 47/340 (13%) Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQAL 297 HSG V+ L W+P+ I SAS D + +WN T + I +L W + Sbjct: 65 HSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAI---------KLHCPWVMEC- 114 Query: 298 VSISANGFINFVNPELGSIDQVRYGHNKAITALSSSA--DGKTLFSADAEGHINSWDIST 355 + + NG + G +D +I LSS A DG S GH Sbjct: 115 -AFAPNG----QSVACGGLDSA-----CSIFNLSSQADRDGNMPVSRVLTGHKG-----Y 159 Query: 356 GISNRVFPDVHATMITGIKTTSKGDLFTVSWD----DHLKVVPAGGSGVDSSKAVANKLS 411 S + PD +ITG GD V WD + + + ++ ++ ++ Sbjct: 160 ASSCQYVPDQETRLITG-----SGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSIN 214 Query: 412 SQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSK 471 S + +S D V + I S T + + V D Q G D Sbjct: 215 SLNANMFISGSCDTTVR--LWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGT 272 Query: 472 VHVYKLSGASVSEVKTIVHPAE-------ITSVAFSNNGAFLVATDQSRKVIPY-SVANN 523 ++ + +V P +TSVAFS +G L A + + ++ Sbjct: 273 CRLFDMRTGHQLQVYN-REPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAE 331 Query: 524 FELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVW 563 L H +++C+ S D L TGS D ++ +W Sbjct: 332 MVLNLGTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIW 371 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 75/360 (20%), Positives = 131/360 (36%), Gaps = 69/360 (19%) Query: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDG 202 L G + + S+D+ P + + I+S S D + ++ + H +V + P+G Sbjct: 62 LQGHSGKVYSLDWTPEKNW-IVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPNG 120 Query: 203 SLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG-TKIASASADK 261 A G D ++N S H G + PD T++ + S D+ Sbjct: 121 QSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQ 180 Query: 262 TIKIWNVATLK----VEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSID 317 T +W+V T + P G + L I S++AN FI+ GS D Sbjct: 181 TCVLWDVTTGQRISIFGSEFPSGHTADVLSLSI-------NSLNANMFIS------GSCD 227 Query: 318 ---------------QVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVF 362 + +GH I ++ DG+ + +G +D+ TG +V+ Sbjct: 228 TTVRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVY 287 Query: 363 ---PDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAV 419 PD + D+ L +V +VA +S + L A Sbjct: 288 NREPDRN--------------------DNELPIV----------TSVAFSISGRLL-FAG 316 Query: 420 SADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSG 479 ++GD V + + G L + SC+ LS+D + G D + ++ SG Sbjct: 317 YSNGDCYVWDTLLAEMVLNLGTL-QNSHEGRISCLGLSSDGSALCTGSWDKNLKIWAFSG 375 Score = 31.2 bits (69), Expect = 1.3, Method: Compositional matrix adjust. Identities = 35/169 (20%), Positives = 70/169 (41%), Gaps = 28/169 (16%) Query: 459 DKQFVAVGGQDSKVHVYK-LSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIP 517 +K ++ QD ++ V+ L+ +K +H + AF+ NG + Sbjct: 77 EKNWIVSASQDGRLIVWNALTSQKTHAIK--LHCPWVMECAFAPNGQSVACGGLDSACSI 134 Query: 518 YSVANNFE----LAHTNSWTFHTAKVACVSWSPDN-VRLATGSLDNSVIVWNMNK----- 567 +++++ + + + T H + + PD RL TGS D + ++W++ Sbjct: 135 FNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRIS 194 Query: 568 ------PSDHPIIIKGAHAMS-SVNSVIWLNETTIVSAGQDSNIKFWNV 609 PS H A +S S+NS LN +S D+ ++ W++ Sbjct: 195 IFGSEFPSGHT-----ADVLSLSINS---LNANMFISGSCDTTVRLWDL 235 Score = 31.2 bits (69), Expect = 1.4, Method: Compositional matrix adjust. Identities = 23/100 (23%), Positives = 41/100 (41%), Gaps = 7/100 (7%) Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWN-MNKPS 569 Q R + + N +L + H+ KV + W+P+ + + S D +IVWN + Sbjct: 44 QGRTAVSF---NPTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQK 100 Query: 570 DHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 H I + H + N ++ G DS +N+ Sbjct: 101 THAIKL---HCPWVMECAFAPNGQSVACGGLDSACSIFNL 137 >4LG8-A nrPDB Length = 354 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 51/216 (23%), Positives = 94/216 (43%), Gaps = 34/216 (15%) Query: 152 SVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGD 211 ++D PS +I++G D V +F+ + +T HTK V SV ++P L S D Sbjct: 76 ALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPD 135 Query: 212 GTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATL 271 TI +++ + + V AH +V GL+ G + S+S D + W + + Sbjct: 136 ATIRIWSVPNASCVQVVR-------AHESAVTGLSLHATGDYLLSSSDD---QYWAFSDI 185 Query: 272 KVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSID-QVRY--------- 321 + + + T++ D+ G T +G I G++D Q++ Sbjct: 186 QTGRVL---TKVTDETSGCSLT---CAQFHPDGLIFGT----GTMDSQIKIWDLKERTNV 235 Query: 322 ----GHNKAITALSSSADGKTLFSADAEGHINSWDI 353 GH+ IT+++ S +G L +A + + WD+ Sbjct: 236 ANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDL 271 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 24/92 (26%), Positives = 48/92 (52%), Gaps = 7/92 (7%) Query: 197 RYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIAS 256 +++PDG +F + D I +++ + T F HSG + + +S +G +A+ Sbjct: 207 QFHPDGLIFGTGTMDSQIKIWDLKERTNVANFP-------GHSGPITSIAFSENGYYLAT 259 Query: 257 ASADKTIKIWNVATLKVEKTIPVGTRIEDQQL 288 A+ D ++K+W++ LK KT+ + E + L Sbjct: 260 AADDSSVKLWDLRKLKNFKTLQLDNNFEVKSL 291 Score = 38.1 bits (87), Expect = 0.012, Method: Compositional matrix adjust. Identities = 73/303 (24%), Positives = 134/303 (44%), Gaps = 35/303 (11%) Query: 238 HSGSVFG---LTWSP-DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW- 292 HS S+ G L P D KI + ADK + +++ ++ ++ T+ T+ + +++ Sbjct: 67 HSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTK---KVTSVVFH 123 Query: 293 -TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 ++ + S S + I + S QV H A+T LS A G L S+ + + Sbjct: 124 PSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFS 183 Query: 352 DISTG-ISNRVFPDVHATMITGIKTTSKGDLF-TVSWDDHLKVVPAGGSGVDSSKAVAN- 408 DI TG + +V + +T + G +F T + D +K+ + VAN Sbjct: 184 DIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIW-----DLKERTNVANF 238 Query: 409 KLSSQPL-GLAVSADG-DIAVAACYKHIAIYSHGKLTE---VPISYNSSCVALSNDKQ-- 461 S P+ +A S +G +A AA + ++ KL + + N +L D+ Sbjct: 239 PGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGT 298 Query: 462 FVAVGGQDSKVHVYKLSGASVSEVKTIVHPAE----ITSVAFSNNGAFLVATDQSRKVIP 517 ++A+GG D ++++ K + I+H E T VAF ++ F+ +T R + Sbjct: 299 YLALGGTDVQIYICK-------QWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKF 351 Query: 518 YSV 520 YS+ Sbjct: 352 YSL 354 Score = 38.1 bits (87), Expect = 0.013, Method: Compositional matrix adjust. Identities = 37/159 (23%), Positives = 63/159 (39%), Gaps = 12/159 (7%) Query: 63 TVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVG 122 T A+ P G +G + ++IWD + T++ P SGP+ I++ +A Sbjct: 204 TCAQFHPDGLIFGTGTMDSQIKIWDLKERTNV--ANFPGHSGPITSIAFSENGYYLATAA 261 Query: 123 EGRERFGHVFLFDTGTSNGNLTGQAR---AMNSVDFKPSRPFRIISGSDDNTVAIFEGPP 179 + V L+D T Q + S+ F S + + G+D V I+ Sbjct: 262 DDSS----VKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD---VQIYICKQ 314 Query: 180 FKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN 218 + F EH+ V + ASTG D ++ Y+ Sbjct: 315 WTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYS 353 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 24/141 (17%), Positives = 62/141 (43%), Gaps = 4/141 (2%) Query: 469 DSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAH 528 D+ + ++ + AS +V H + +T ++ G +L+++ + + L Sbjct: 135 DATIRIWSVPNASCVQV-VRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTK 193 Query: 529 TNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVI 588 T + C + PD + TG++D+ + +W++ + ++ + H+ + Sbjct: 194 VTDET-SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN--VANFPGHSGPITSIAF 250 Query: 589 WLNETTIVSAGQDSNIKFWNV 609 N + +A DS++K W++ Sbjct: 251 SENGYYLATAADDSSVKLWDL 271 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 17/64 (26%), Positives = 32/64 (50%), Gaps = 2/64 (3%) Query: 547 DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKF 606 D ++ TG D +V+V++ K S+ + H + V ++ + SA D+ I+ Sbjct: 83 DTNKILTGGADKNVVVFD--KSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRI 140 Query: 607 WNVP 610 W+VP Sbjct: 141 WSVP 144 >5Y1U-A nrPDB Length = 456 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 38/141 (26%), Positives = 69/141 (48%), Gaps = 13/141 (9%) Query: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF-------EGPPFKFKSTFGEHTKFVHS 195 L G + + + P+ ++S SDD+T+ ++ EG K+ F HT V Sbjct: 204 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 263 Query: 196 VRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKI 254 V ++ SLF S D +++++ T++ S AH+ V L+++P I Sbjct: 264 VSWHLLHESLFGSVADDQKLMIWD----TRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI 319 Query: 255 -ASASADKTIKIWNVATLKVE 274 A+ SADKT+ +W++ LK++ Sbjct: 320 LATGSADKTVALWDLRNLKLK 340 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 53/238 (22%), Positives = 109/238 (45%), Gaps = 36/238 (15%) Query: 70 SGYYCASGDVHGNVRIWDTTQTTHILKTTIP--VFSGP---VKDISWDSESKRI-AAVGE 123 SG+ ++ D H + +WD + K +F+G V+D+SW + + +V + Sbjct: 221 SGHLLSASDDH-TICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVAD 279 Query: 124 GRERFGHVFLFDTGTSN-----GNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP 178 ++ + ++DT ++N ++ +N + F P F + +GS D TVA+++ Sbjct: 280 DQK----LMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 335 Query: 179 PFKFK-STFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV 236 K K +F H + V+++P + ++ AS+G D + ++ D +K G E+ S ++ Sbjct: 336 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW---DLSKIG--EEQSPEDA 390 Query: 237 ------------AHSGSVFGLTWSPDGT-KIASASADKTIKIWNVATLKVEKTIPVGT 281 H+ + +W+P+ I S S D +++W +A P G+ Sbjct: 391 EDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGS 448 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 33/110 (30%), Positives = 55/110 (50%), Gaps = 15/110 (13%) Query: 507 VATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVWNM 565 VA DQ K++ + +N ++S HTA+V C+S++P LATGS D +V +W++ Sbjct: 277 VADDQ--KLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL 334 Query: 566 NKPSDHPIIIKGAHAMSS----VNSVIW--LNETTIVSAGQDSNIKFWNV 609 + H+ S + V W NET + S+G D + W++ Sbjct: 335 RN------LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 378 >2HES-X nrPDB Length = 330 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 48/206 (23%), Positives = 82/206 (39%), Gaps = 27/206 (13%) Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV-AHSGSVFGLTW 247 H K + SV + P SL A+ D T+ ++ + + FE D L + H V G+ W Sbjct: 57 HKKAIRSVAWRPHTSLLAAGSFDSTVSIW-AKEESADRTFEMDLLAIIEGHENEVKGVAW 115 Query: 248 SPDGTKIASASADKTIKIWNVATLKVE-KTIPVGTRIEDQQLGIIWT-KQALVSISANG- 304 S DG +A+ S DK++ IW E + I V +IW +AL++ S+ Sbjct: 116 SNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDD 175 Query: 305 -------------FINFVNPELGSIDQVRYGHNKAITALSSSADGKTL----FSADAEGH 347 + +N G++ + + + L S +D T+ + D E Sbjct: 176 TVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDD 235 Query: 348 INSWDISTGISNRVFPDVHATMITGI 373 W + + PDVH + + Sbjct: 236 QQEW-----VCEAILPDVHKRQVYNV 256 Score = 45.4 bits (106), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 47/178 (26%), Positives = 80/178 (44%), Gaps = 15/178 (8%) Query: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILK--TTIPVFSGPVKDISWD-SE 114 H ++ S GYY A+ +V IW+T ++ + + + S VK + W SE Sbjct: 106 HENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSE 165 Query: 115 SKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDF-KPSRPFRIISGSDDNTVA 173 + ++ + R + D L G + S DF K FR+ SGSDD+TV Sbjct: 166 ALLASSSYDDTVRIWKDY-DDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVR 224 Query: 174 IF--------EGPPFKFKSTFGE-HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDG 222 ++ + + ++ + H + V++V + +G L AS G DG + +Y VDG Sbjct: 225 VWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNG-LIASVGADGVLAVYEEVDG 281 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 34/137 (24%), Positives = 63/137 (45%), Gaps = 11/137 (8%) Query: 480 ASVSEVKTI-VHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAK 538 AS++ +K++ ++ +I S FS +TD+ K++ ++F L T H Sbjct: 2 ASINLIKSLKLYKEKIWSFDFSQGILATGSTDRKIKLVSVKY-DDFTLIDVLDETAHKKA 60 Query: 539 VACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPI------IIKGAHAMSSVNSVIWLNE 592 + V+W P LA GS D++V +W + +D II+G + V V W N+ Sbjct: 61 IRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHE--NEVKGVAWSND 118 Query: 593 -TTIVSAGQDSNIKFWN 608 + + +D ++ W Sbjct: 119 GYYLATCSRDKSVWIWE 135 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 39/156 (25%), Positives = 62/156 (39%), Gaps = 9/156 (5%) Query: 462 FVAVGGQDSKVHVYKLSGASVSEVKTI---VHPAEITSVAFSNNGAFLVATDQSRKVIPY 518 +A G D K+ + + + + + H I SVA+ + + L A V + Sbjct: 26 ILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIW 85 Query: 519 ----SVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPII 574 S FE+ H +V V+WS D LAT S D SV +W ++ + Sbjct: 86 AKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYEC 145 Query: 575 IKGAHAMSS-VNSVIWL-NETTIVSAGQDSNIKFWN 608 I S V VIW +E + S+ D ++ W Sbjct: 146 ISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWK 181 Score = 28.9 bits (63), Expect = 6.0, Method: Compositional matrix adjust. Identities = 12/36 (33%), Positives = 19/36 (52%) Query: 231 DSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIW 266 D L AH ++ + W P + +A+ S D T+ IW Sbjct: 50 DVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIW 85 >6GMH-W nrPDB Length = 305 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 93/213 (43%), Gaps = 36/213 (16%) Query: 68 SPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVG---EG 124 SP Y A+G TH+ K I K+ S D+ K I ++ +G Sbjct: 115 SPDSQYLATG--------------THVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDG 160 Query: 125 RERF-----GHVFLFD--TGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEG 177 + G + +FD TG L G A + S+ F P +++ SDD + I++ Sbjct: 161 KYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQL-LVTASDDGYIKIYDV 219 Query: 178 PPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGV--FEDDSLKN 235 T H +V +V + PD + F S+ D ++ +++ GT+T V F D Sbjct: 220 QHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDV--GTRTCVHTFFD----- 272 Query: 236 VAHSGSVFGLTWSPDGTKIASASADKTIKIWNV 268 H V+G+ ++ +G+KI S D+ I I++ Sbjct: 273 --HQDQVWGVKYNGNGSKIVSVGDDQEIHIYDC 303 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 48/200 (24%), Positives = 88/200 (44%), Gaps = 18/200 (9%) Query: 74 CASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWD---SESKRIAAVGEGRERFGH 130 AS + ++R+WD I + +GPV +W S + A G + + Sbjct: 79 AASSSLDAHIRLWDLENGKQIKS----IDAGPVD--AWTLAFSPDSQYLATGTHVGKV-N 131 Query: 131 VFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHT 190 +F ++G +L + + + S+ + P + + SG+ D + IF+ K T H Sbjct: 132 IFGVESGKKEYSLDTRGKFILSIAYSPDGKY-LASGAIDGIINIFDIATGKLLHTLEGHA 190 Query: 191 KFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD 250 + S+ ++PD L + DG I +Y+ G H+ V + + PD Sbjct: 191 MPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLS-------GHASWVLNVAFCPD 243 Query: 251 GTKIASASADKTIKIWNVAT 270 T S+S+DK++K+W+V T Sbjct: 244 DTHFVSSSSDKSVKVWDVGT 263 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 34/138 (24%), Positives = 63/138 (45%), Gaps = 2/138 (1%) Query: 242 VFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSIS 301 + + +SPDG +AS + D I I+++AT K+ T+ G + + L Q LV+ S Sbjct: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLE-GHAMPIRSLTFSPDSQLLVTAS 209 Query: 302 ANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRV 361 +G+I + + ++ GH + ++ D S+ ++ + WD+ T Sbjct: 210 DDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHT 269 Query: 362 FPDVHATMITGIKTTSKG 379 F D H + G+K G Sbjct: 270 FFD-HQDQVWGVKYNGNG 286 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 39/141 (27%), Positives = 61/141 (43%), Gaps = 15/141 (10%) Query: 230 DDSLKNVAHSGSVFGLTWSPDGTKI--------------ASASADKTIKIWNVATLKVEK 275 DD +K L WS +G ++ AS+S D I++W++ K K Sbjct: 41 DDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIK 100 Query: 276 TIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSAD 335 +I G ++ L Q L + + G +N E G + K I +++ S D Sbjct: 101 SIDAGP-VDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPD 159 Query: 336 GKTLFSADAEGHINSWDISTG 356 GK L S +G IN +DI+TG Sbjct: 160 GKYLASGAIDGIINIFDIATG 180 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 41/164 (25%), Positives = 70/164 (42%), Gaps = 18/164 (10%) Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV-HPAEITSVAFSNNGAFLVATDQS 512 +A S D +++A G D ++++ ++ + + T+ H I S+ FS + LV Sbjct: 154 IAYSPDGKYLASGAIDGIINIFDIATGKL--LHTLEGHAMPIRSLTFSPDSQLLVTASDD 211 Query: 513 RKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHP 572 + Y V + LA T S H + V V++ PD+ + S D SV VW++ + Sbjct: 212 GYIKIYDV-QHANLAGTLS--GHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRT--- 265 Query: 573 IIIKGAHAMSSVNSVIW-----LNETTIVSAGQDSNIKFWNVPF 611 H +W N + IVS G D I ++ P Sbjct: 266 ----CVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDCPI 305 >4J0W-A nrPDB Length = 343 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 28/128 (21%), Positives = 66/128 (51%), Gaps = 5/128 (3%) Query: 483 SEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACV 542 +E K H + + +A S++G +L + D+S+ ++ + + H ++T H V+ + Sbjct: 59 AEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQS---CQHLYTFTGHRDAVSGL 115 Query: 543 SWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDS 602 ++ +L + S D SV VWN+ + S + A+++++++ E + + G+D Sbjct: 116 AFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALS--RECCVTAGGRDG 173 Query: 603 NIKFWNVP 610 ++ W +P Sbjct: 174 TVRVWKIP 181 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 35/158 (22%), Positives = 71/158 (44%), Gaps = 10/158 (6%) Query: 453 CVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV-HPAEITSVAFSNNGAFLVATDQ 511 C+A+S+D +++A G + + +++ S + T H ++ +AF L +T Sbjct: 72 CMAISSDGKYLASGDRSKLILIWE--AQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSH 129 Query: 512 SRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDH 571 R V ++VA N ++ + H VA + + G D +V VW + P + Sbjct: 130 DRSVKVWNVAEN---SYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKI--PEES 184 Query: 572 PIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 ++ G S++ + +NE +VS D ++ W + Sbjct: 185 QLVFYGHQG--SIDCIHLINEEHMVSGADDGSVALWGL 220 Score = 37.7 bits (86), Expect = 0.014, Method: Compositional matrix adjust. Identities = 73/317 (23%), Positives = 113/317 (35%), Gaps = 42/317 (13%) Query: 200 PDGSLFASTGGDGTIVLYNGVDGTKTGVF----EDDSLKNVAHSGSVFGLTWSPDGTKIA 255 PD S S D +I+ ++ G K V + K HS V + S DG +A Sbjct: 24 PDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLA 83 Query: 256 SASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGS 315 S K I IW + + T G R L L S S + + N S Sbjct: 84 SGDRSKLILIWEAQSCQHLYTF-TGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENS 142 Query: 316 IDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKT 375 + +GH A+ AL + + + + +G + W I P+ + G + Sbjct: 143 YVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKI---------PEESQLVFYGHQG 193 Query: 376 TSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLS-SQPLGLAVSADGDIAVAACYKHI 434 + D + ++H+ SG D LS +PL L A G Sbjct: 194 SI--DCIHLINEEHMV------SGADDGSVALWGLSKKRPLALQREAHGLRGEPG----- 240 Query: 435 AIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVH---P 491 E P +S L+ D VA G S V +++ G ++ + Sbjct: 241 --------LEQPFWISSVAALLNTD--LVATGSHSSCVRLWQ-CGEGFRQLDLLCDIPLV 289 Query: 492 AEITSVAFSNNGAFLVA 508 I S+ FS++G FLVA Sbjct: 290 GFINSLKFSSSGDFLVA 306 Score = 30.4 bits (67), Expect = 2.5, Method: Compositional matrix adjust. Identities = 20/81 (24%), Positives = 34/81 (41%), Gaps = 7/81 (8%) Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 H+ V + + DG AS I+++ F H +V GL + Sbjct: 66 HSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTF-------TGHRDAVSGLAFR 118 Query: 249 PDGTKIASASADKTIKIWNVA 269 ++ S S D+++K+WNVA Sbjct: 119 RGTHQLYSTSHDRSVKVWNVA 139 >3CFV-B nrPDB Length = 414 Score = 45.8 bits (107), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 36/135 (26%), Positives = 65/135 (48%), Gaps = 20/135 (14%) Query: 150 MNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFK-STFGEHTKFVHSVRYNP-DGSLFAS 207 +N + F P F + +GS D TVA+++ K K TF H + V ++P + ++ AS Sbjct: 278 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILAS 337 Query: 208 TGGDGTIVLYNGVDGTKTGVFEDDSLKNV------------AHSGSVFGLTWSPDGT-KI 254 +G D + ++ D +K G E+ S ++ H+ + +W+P+ I Sbjct: 338 SGTDRRLNVW---DLSKIG--EEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVI 392 Query: 255 ASASADKTIKIWNVA 269 S S D ++IW +A Sbjct: 393 CSVSEDNIMQIWQMA 407 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 35/122 (28%), Positives = 62/122 (50%), Gaps = 13/122 (10%) Query: 162 RIISGSDDNTVAIF-------EGPPFKFKSTFGEHTKFVHSVRYNP-DGSLFASTGGDGT 213 ++S SDD+TV ++ EG K+ F H+ V V ++ SLF S D Sbjct: 194 HLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQK 253 Query: 214 IVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKI-ASASADKTIKIWNVATLK 272 +++++ T++ S AH+ V L+++P I A+ SADKT+ +W++ LK Sbjct: 254 LMIWD----TRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK 309 Query: 273 VE 274 ++ Sbjct: 310 LK 311 Score = 37.0 bits (84), Expect = 0.023, Method: Compositional matrix adjust. Identities = 26/82 (31%), Positives = 41/82 (50%), Gaps = 13/82 (15%) Query: 535 HTAKVACVSWSP-DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSS----VNSVIW 589 HTA+V C+S++P LATGS D +V +W++ + H S + V W Sbjct: 274 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRN------LKLKLHTFESHKDEIFQVHW 327 Query: 590 --LNETTIVSAGQDSNIKFWNV 609 NET + S+G D + W++ Sbjct: 328 SPHNETILASSGTDRRLNVWDL 349 >5XYI-g nrPDB Length = 335 Score = 45.8 bits (107), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 66/307 (21%), Positives = 110/307 (35%), Gaps = 58/307 (18%) Query: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDI---SWDSE 114 H+H + S + + +R+WD + +TT +F G KD+ ++ Sbjct: 79 HNHFVSDVSLSRDASHLLTSSWDSTLRLWDLST-----RTTKKLFLGHKKDVLGVTFSPC 133 Query: 115 SKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKP----SRPFRIISGSDDN 170 ++RI +VG R V +++ N + + SV P + P I G D Sbjct: 134 NRRIISVG----RDNQVKIWNILGENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDG 189 Query: 171 TVAIFE-GPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFE 229 V I+ K F H SV + PDG + G D +V++ +G KT F Sbjct: 190 KVYIWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFT 249 Query: 230 DDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLG 289 S V + P I +A+ + I +W+ Sbjct: 250 APS--------PVHAVAACPTQAWICAATYEG-IAVWD---------------------- 278 Query: 290 IIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHIN 349 I A I+ V P + G T L+ +ADG L+S +G I Sbjct: 279 ----------IGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIR 328 Query: 350 SWDISTG 356 +W++ + Sbjct: 329 AWEVKSA 335 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 33/135 (24%), Positives = 55/135 (40%), Gaps = 15/135 (11%) Query: 140 NGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF------EGPPFKFKSTFGEHTKFV 193 G A+ S++ + ++S S D + ++ E F G H FV Sbjct: 26 RATFVGHNAAIESIEIDNEHNY-LVSASRDKSALVWKLNRTQEQWATPFTRLIG-HNHFV 83 Query: 194 HSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTK 253 V + D S ++ D T+ L++ T +F + H V G+T+SP + Sbjct: 84 SDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLF-------LGHKKDVLGVTFSPCNRR 136 Query: 254 IASASADKTIKIWNV 268 I S D +KIWN+ Sbjct: 137 IISVGRDNQVKIWNI 151 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 61/270 (22%), Positives = 108/270 (40%), Gaps = 39/270 (14%) Query: 322 GHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIK-TTSKGD 380 GHN ++ +S S D L ++ + + WD+ST + ++F H + G+ + Sbjct: 78 GHNHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLG-HKKDVLGVTFSPCNRR 136 Query: 381 LFTVSWDDHLKVVPAGG---------SGVDSSKAVANKLSSQPLGLAVSA-DGDIAVAAC 430 + +V D+ +K+ G S V S + PL +AV DG + + Sbjct: 137 IISVGRDNQVKIWNILGENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYI--- 193 Query: 431 YKHIAIYSHGKLTEVPISYNSSC--VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTI 488 +I KL + +++ C V + D ++V GG D KV ++ + KTI Sbjct: 194 ---WSIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGA----KTI 246 Query: 489 --VHPAEITSVAFSNNGAFLV-ATDQSRKVIPYSVANNFELAHTNSWTF---------HT 536 P+ + +VA A++ AT + V +L N F T Sbjct: 247 SFTAPSPVHAVAACPTQAWICAATYEGIAVWDIGAKQQIDLVQPN---FKHEGKRNAGRT 303 Query: 537 AKVACVSWSPDNVRLATGSLDNSVIVWNMN 566 C++W+ D L +G D S+ W + Sbjct: 304 PDCTCLAWAADGSVLYSGYNDGSIRAWEVK 333 Score = 35.4 bits (80), Expect = 0.075, Method: Compositional matrix adjust. Identities = 28/122 (22%), Positives = 53/122 (43%), Gaps = 4/122 (3%) Query: 490 HPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHT--NSWTFHTAKVACVSWSPD 547 H A I S+ N +LV+ + + + + + E T H V+ VS S D Sbjct: 32 HNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLSRD 91 Query: 548 NVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFW 607 L T S D+++ +W+++ + + + H + I+S G+D+ +K W Sbjct: 92 ASHLLTSSWDSTLRLWDLSTRTTKKLFL--GHKKDVLGVTFSPCNRRIISVGRDNQVKIW 149 Query: 608 NV 609 N+ Sbjct: 150 NI 151 >5OQL-J nrPDB Length = 912 Score = 45.4 bits (106), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 21/43 (48%), Positives = 29/43 (67%) Query: 232 SLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVE 274 SL+ +AH + L SP+G ASAS DKT+KIW+V L+V+ Sbjct: 537 SLRRLAHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQ 579 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 30/56 (53%) Query: 211 DGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIW 266 DG I +++ T T V+ D K AH +V + +SP+ + S S DKT+ +W Sbjct: 204 DGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLW 259 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 47/224 (20%), Positives = 84/224 (37%), Gaps = 42/224 (18%) Query: 160 PFRIISGSDDNTVAIFEGPPF-----KFKSTFGE--HTKFVHSVRYNPDGSLFASTGGDG 212 P +ISGS D V + P K S+ H K ++++ +P+G LFAS D Sbjct: 507 PAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDK 566 Query: 213 TIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTK--------------IASAS 258 T+ +++ G+ H V+ + ++P T + + S Sbjct: 567 TVKIWDVEKLEVQGILR-------GHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGS 619 Query: 259 ADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW-----------TKQALVSISANGFIN 307 DKTIK+WN++ +T + L ++W TK S A+ + Sbjct: 620 GDKTIKLWNLSDYTCIRTFEGHSH---NVLKVVWLHISRDDSITKTKVQFASAGADTLVK 676 Query: 308 FVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 + G + H + L+ + L SA ++ + W Sbjct: 677 VWDANTGETECTLDNHEDRLWTLAVHSKTNILASAGSDSKVTFW 720 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 21/77 (27%), Positives = 38/77 (49%), Gaps = 8/77 (10%) Query: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSS--VNSVIWLNE 592 H + V C+++SP+ L +GS D ++ +W I +G + + SV +LNE Sbjct: 231 HESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDG-----IWQGTPMLRHELLESVGFLNE 285 Query: 593 TT-IVSAGQDSNIKFWN 608 + SAG ++ W+ Sbjct: 286 GKWMYSAGTSGVLRIWD 302 Score = 30.0 bits (66), Expect = 3.2, Method: Compositional matrix adjust. Identities = 27/125 (21%), Positives = 59/125 (47%), Gaps = 8/125 (6%) Query: 446 PISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAF 505 PI Y VAL N + +A ++ + +G ++E++ P I+++ + +G+ Sbjct: 19 PI-YTGGSVALENGARILASTLGENAILTELNTGKRLAEIQGDGEP--ISTLTITPSGSH 75 Query: 506 LVATDQSRKVIPYSVA-----NNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSV 560 L+ +S + YS+A ++ E + H V ++ + LATG+ D ++ Sbjct: 76 LIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAI 135 Query: 561 IVWNM 565 +W++ Sbjct: 136 KIWDI 140 Score = 29.6 bits (65), Expect = 3.8, Method: Compositional matrix adjust. Identities = 36/150 (24%), Positives = 57/150 (38%), Gaps = 38/150 (25%) Query: 488 IVHPAEITSVAFSNN----GAFLVATDQSRKV----IPYSVANNFELAHTNSWTFHTAKV 539 +V PA S AF N AFL++ Q R V IP + +L + H + Sbjct: 490 VVPPA--NSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDI 547 Query: 540 ACVSWSPDNVRLATGSLDNSVIVWNMNK--------------------PSDHPIIIKGAH 579 + SP+ A+ S D +V +W++ K P + P +I+G Sbjct: 548 NALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTP-VIQGEQ 606 Query: 580 AMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 S V +++ D IK WN+ Sbjct: 607 GSVSGRGV-------VLTGSGDKTIKLWNL 629 >5OV3-A nrPDB Length = 381 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 66/292 (22%), Positives = 119/292 (40%), Gaps = 45/292 (15%) Query: 177 GPPFKFKSTFGEH-----------TKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKT 225 GP + +FG++ + +N G+L A DG IV++ D Sbjct: 1 GPNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIW---DFLTR 57 Query: 226 GVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKT-------IP 278 G+ + S AH V L WS DG K+ SAS D + W+V + ++ + Sbjct: 58 GIAKIIS----AHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILK 113 Query: 279 VGTRIEDQ-QLGIIWTKQALVSISANGFINFVNP--ELGSIDQVRYGHNKAITALSSSAD 335 V DQ ++ + K A V ++ + + V P + ++ V + + +A Sbjct: 114 VQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAK 173 Query: 336 GKTL-FSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHL---- 390 GK L D++ + S+ ++TG SN T I I+ KG F ++ D + Sbjct: 174 GKILVLKTDSQDLVASFRVTTGTSN-------TTAIKSIEFARKGSCFLINTADRIIRVY 226 Query: 391 ---KVVPAGGSGV-DSSKAVANKLSSQPL-GLAVSADGDIAVAACYKHIAIY 437 +++ G G + + + + ++ P S DG+ VA + A+Y Sbjct: 227 DGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALY 278 >6N9G-C nrPDB Length = 353 Score = 45.1 bits (105), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 47/210 (22%), Positives = 87/210 (41%), Gaps = 20/210 (9%) Query: 68 SPSGYYCASGDVHGNVRIW----DTTQTTHILKTTIPVFSGPVKDISW-DSESKRIAAVG 122 +PSG A G + ++ D + K ++ + + + S+ +S+ + + A G Sbjct: 114 APSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASG 173 Query: 123 EGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFR-IISGSDDNTVAIFEGPPFK 181 +G V ++G + G + +D PS +SG D +++ + Sbjct: 174 DGTCALWDV---ESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQ 230 Query: 182 FKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGS 241 F H V+SVRY P G FAS D T LY+ + ++ +S+ Sbjct: 231 CVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESI-------- 282 Query: 242 VFG---LTWSPDGTKIASASADKTIKIWNV 268 +FG + +S G + + D TI +W+V Sbjct: 283 IFGASSVDFSLSGRLLFAGYNDYTINVWDV 312 Score = 33.5 bits (75), Expect = 0.29, Method: Compositional matrix adjust. Identities = 13/30 (43%), Positives = 17/30 (56%) Query: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWN 564 H KV C+ W D R+ + S D VIVW+ Sbjct: 62 HGNKVLCMDWCKDKRRIVSSSQDGKVIVWD 91 Score = 29.6 bits (65), Expect = 4.0, Method: Compositional matrix adjust. Identities = 35/167 (20%), Positives = 71/167 (42%), Gaps = 18/167 (10%) Query: 453 CVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAE-ITSVAFSNNGAFLVA--T 509 C+ DK+ + QD KV V+ + ++ + P + + A++ +G + Sbjct: 68 CMDWCKDKRRIVSSSQDGKVIVW--DSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGL 125 Query: 510 DQSRKVIPYSVANNFELA-HTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKP 568 D V P + N +A S HT ++ S++ ++++ T S D + +W++ Sbjct: 126 DNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESG 185 Query: 569 SDHPIIIKGAHAMSSVNSVIWLN----ET--TIVSAGQDSNIKFWNV 609 +++ H + V+ L+ ET T VS G D W++ Sbjct: 186 Q----LLQSFHGHGA--DVLCLDLAPSETGNTFVSGGCDKKAMVWDM 226 >3JB9-g nrPDB Length = 558 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 43/203 (21%), Positives = 82/203 (40%), Gaps = 20/203 (9%) Query: 70 SGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSG---PVKDISWDSESKRIAAVGEGRE 126 SG+ SG + ++IW+ +L+T F G P++D+S+ + + + + Sbjct: 278 SGHLLLSGSMDNQIKIWEVYHDRSLLRT----FQGHARPIRDLSFSQDGRSFLSTSFDKT 333 Query: 127 RFGHVFLFDTGTSNG-NLTGQARAMNSVDFK--PSRPFRIISGSDDNTVAIFEGPPFKFK 183 + L+DT N R N V F+ P +P ++G+ D + F+ Sbjct: 334 ----IKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDIRSPDIV 389 Query: 184 STFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVF 243 + H ++S+ + +G F +T D ++ + D ++ HS Sbjct: 390 QAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPIKFVADIAM----HSMPRV 445 Query: 244 GLTWSPDGTKIASASADKTIKIW 266 L P+G IA S D I ++ Sbjct: 446 AL--RPNGKSIACQSLDNCIYVY 466 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 53/260 (20%), Positives = 92/260 (35%), Gaps = 55/260 (21%) Query: 145 GQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFK-FKSTFGEHTKFVHSVRYNPDGS 203 G + ++ + F P ++SGS DN + I+E + TF H + + + ++ DG Sbjct: 264 GHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDGR 323 Query: 204 LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA-------------------------- 237 F ST D TI L++ G F D L N Sbjct: 324 SFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDI 383 Query: 238 -----------HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVG--TRIE 284 H G + +T+ +G + + S D +++ W T +P+ I Sbjct: 384 RSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGT-----PVPIKFVADIA 438 Query: 285 DQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSA---------D 335 + + + SI+ N + + ++ R K S S D Sbjct: 439 MHSMPRVALRPNGKSIACQSLDNCIY-VYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSPD 497 Query: 336 GKTLFSADAEGHINSWDIST 355 G+ +FS D+ G+ WD T Sbjct: 498 GRFVFSGDSSGNACFWDWKT 517 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 31/98 (31%), Positives = 44/98 (44%), Gaps = 11/98 (11%) Query: 179 PFKFKSTFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV- 236 P K T+ HTK + +R+ P G L S D I ++ V+ D SL Sbjct: 255 PKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWE--------VYHDRSLLRTF 306 Query: 237 -AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKV 273 H+ + L++S DG S S DKTIK+W+ K Sbjct: 307 QGHARPIRDLSFSQDGRSFLSTSFDKTIKLWDTELGKC 344 Score = 32.7 bits (73), Expect = 0.53, Method: Compositional matrix adjust. Identities = 19/53 (35%), Positives = 28/53 (52%), Gaps = 3/53 (5%) Query: 68 SPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWD-SESKRIA 119 SP G + SGD GN WD T L +P SGPV+ +++ E+ ++A Sbjct: 495 SPDGRFVFSGDSSGNACFWD--WKTCKLMAKLPAHSGPVQSMAFHPQETSKVA 545 Score = 32.0 bits (71), Expect = 0.81, Method: Compositional matrix adjust. Identities = 20/82 (24%), Positives = 36/82 (43%), Gaps = 2/82 (2%) Query: 528 HTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNS 586 H +W HT ++C+ + P L +GS+DN + +W + +G HA + Sbjct: 258 HIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQG-HARPIRDL 316 Query: 587 VIWLNETTIVSAGQDSNIKFWN 608 + + +S D IK W+ Sbjct: 317 SFSQDGRSFLSTSFDKTIKLWD 338 >5WLC-LU nrPDB Length = 489 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 81/337 (24%), Positives = 134/337 (39%), Gaps = 52/337 (15%) Query: 308 FVNPELGSIDQVRYGHNKAITALSSSADG-KTLFSADAEGHINSWDISTGISNRVFPDVH 366 F P +G Q+ YGH + A++ + L + A+G I W++ST F H Sbjct: 54 FAKPFVG---QLGYGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFK-AH 109 Query: 367 ATMITGIKTTS------KGDL----FTVSWDDHLKVVPAGGSGVDSSKAVANKLSS---- 412 ++TG+ T K DL F +S D K V VD +NK SS Sbjct: 110 YGLVTGLCVTQPRFHDKKPDLKSQNFMLSCSDD-KTVKLWSINVDD---YSNKNSSDNDS 165 Query: 413 --QPLGLAVSADGDIAVAACYKH------------IAIYSHGKLTEVP-ISYNSSCVAL- 456 GL + DG+ A H I ++ +L V +S+ + + Sbjct: 166 VTNEEGLIRTFDGESAFQGIDSHRENSTFATGGAKIHLWDVNRLKPVSDLSWGADNITSL 225 Query: 457 ---SNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAF-LVATDQS 512 N+ +A G D+ + +Y L S ++ IV ++ ++ AF V ++ Sbjct: 226 KFNQNETDILASTGSDNSIVLYDLRTNSPTQ--KIVQTMRTNAICWNPMEAFNFVTANED 283 Query: 513 RKVIPYSVANNFELAHT-NSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDH 571 Y + N L+ + N + H + V V +SP + TGS D S+ ++ N H Sbjct: 284 HNAYYYDMRN---LSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTN--HGH 338 Query: 572 PIIIKGAHAMSSVNSVIW-LNETTIVSAGQDSNIKFW 607 I M V V + ++ I+S D N++ W Sbjct: 339 SREIYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLW 375 Score = 28.5 bits (62), Expect = 8.5, Method: Compositional matrix adjust. Identities = 28/111 (25%), Positives = 51/111 (45%), Gaps = 37/111 (33%) Query: 193 VHSVRYNPDGS-LFASTGGDGTIVLYNG---------VDGTKTGVF-------------- 228 + S+++N + + + ASTG D +IVLY+ V +T Sbjct: 222 ITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIVQTMRTNAICWNPMEAFNFVTAN 281 Query: 229 EDDS-----LKNVAHSGSVFG--------LTWSPDGTKIASASADKTIKIW 266 ED + ++N++ S +VF + +SP G +I + S DK+I+I+ Sbjct: 282 EDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIY 332 >5MC6-j nrPDB Length = 397 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 36/123 (29%), Positives = 57/123 (46%), Gaps = 15/123 (12%) Query: 163 IISGSDDNTVAIFE----GPPFKFKS--TFGEHTKFVHSVRYNPDGSLFA---STGGDGT 213 I +G ++ TV I E P + F+S + ++ + SV+++P GSL A + G Sbjct: 200 IATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLAIAHDSNSFGC 259 Query: 214 IVLYNGVDGTKTGVFE------DDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 I LY G + G SL AHS V L+++ G + SA D ++ W+ Sbjct: 260 ITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCSAGWDGKLRFWD 319 Query: 268 VAT 270 V T Sbjct: 320 VKT 322 >5Y88-O nrPDB Length = 451 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 36/147 (24%), Positives = 63/147 (42%), Gaps = 8/147 (5%) Query: 131 VFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHT 190 V+ TG L G + V P+ + S S+D TV ++ + + H Sbjct: 166 VWDLATGKLKTTLAGHVMTVRDVAVSDRHPY-LFSVSEDKTVKCWDLEKNQIIRDYYGHL 224 Query: 191 KFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD 250 V +V +P L A+ G D I L++ T+ V + V H G + + +P Sbjct: 225 SGVRTVSIHPTLDLIATAGRDSVIKLWDM--RTRIPV-----ITLVGHKGPINQVQCTPV 277 Query: 251 GTKIASASADKTIKIWNVATLKVEKTI 277 ++ S+S D T+++W+V K K + Sbjct: 278 DPQVVSSSTDATVRLWDVVAGKTMKVL 304 Score = 38.5 bits (88), Expect = 0.009, Method: Compositional matrix adjust. Identities = 48/197 (24%), Positives = 86/197 (43%), Gaps = 29/197 (14%) Query: 83 VRIWDTTQTTHILKTTIPVFS-----GPVKDISWDSESKRIAAVGEGRERFGHVFLFDT- 136 +++WD ++T IPV + GP+ + ++ + V L+D Sbjct: 248 IKLWD-------MRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTD----ATVRLWDVV 296 Query: 137 -GTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVA--IFEGPPF-KFKSTFGEHTKF 192 G + LT R++ + P + F + S D+ + + EG F+S E T Sbjct: 297 AGKTMKVLTHHKRSVRATALHP-KEFSVASACTDDIRSWGLAEGSLLTNFES---EKTGI 352 Query: 193 VHSVRYNPDGSLFASTGGD-GTIVLYNGVDGTK-TGVFEDDSLKNVAHSGSVFGLTWSPD 250 ++++ N D LFA GGD G + Y+ G K + + + ++ SV T+ Sbjct: 353 INTLSINQDDVLFA--GGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKT 410 Query: 251 GTKIASASADKTIKIWN 267 G ++ + ADK+IKIW Sbjct: 411 GLRLITGEADKSIKIWK 427 Score = 37.7 bits (86), Expect = 0.015, Method: Compositional matrix adjust. Identities = 51/238 (21%), Positives = 96/238 (40%), Gaps = 20/238 (8%) Query: 163 IISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDG 222 I+GS+D T+ +++ K K+T H V V + S D T+ + D Sbjct: 155 FITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCW---DL 211 Query: 223 TKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTR 282 K + D H V ++ P IA+A D IK+W++ T ++ VG + Sbjct: 212 EKNQIIRD----YYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRT-RIPVITLVGHK 266 Query: 283 IEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSA 342 Q+ +VS S + + + G +V H +++ A + ++ SA Sbjct: 267 GPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVASA 326 Query: 343 DAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGV 400 + I SW ++ G +++T ++ G + T+S + + G +GV Sbjct: 327 CTDD-IRSWGLAEG-----------SLLTNFESEKTGIINTLSINQDDVLFAGGDNGV 372 Score = 35.8 bits (81), Expect = 0.061, Method: Compositional matrix adjust. Identities = 37/161 (22%), Positives = 73/161 (45%), Gaps = 13/161 (8%) Query: 453 CVALSN-DKQFVAVGGQDSKVHVYKLSGASVSEVKTIV--HPAEITSVAFSNNGAFLVAT 509 CVA+ D ++ G D+ + V+ L+ ++KT + H + VA S+ +L + Sbjct: 144 CVAIDPVDNEWFITGSNDTTMKVWDLA---TGKLKTTLAGHVMTVRDVAVSDRHPYLFSV 200 Query: 510 DQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPS 569 + + V + + N + + H + V VS P +AT D+ + +W+M + Sbjct: 201 SEDKTVKCWDLEKNQII---RDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMR--T 255 Query: 570 DHPIIIKGAHAMSSVNSVIWLN-ETTIVSAGQDSNIKFWNV 609 P+I H +N V + +VS+ D+ ++ W+V Sbjct: 256 RIPVITLVGHK-GPINQVQCTPVDPQVVSSSTDATVRLWDV 295 Score = 33.1 bits (74), Expect = 0.39, Method: Compositional matrix adjust. Identities = 30/121 (24%), Positives = 54/121 (44%), Gaps = 2/121 (1%) Query: 238 HSGSVFGLTWSP-DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA 296 H G V + P D + S D T+K+W++AT K++ T+ G + + + + Sbjct: 138 HLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTL-AGHVMTVRDVAVSDRHPY 196 Query: 297 LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 L S+S + + + E I + YGH + +S + +A + I WD+ T Sbjct: 197 LFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTR 256 Query: 357 I 357 I Sbjct: 257 I 257 >5K1B-B nrPDB Length = 677 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 53/246 (21%), Positives = 95/246 (38%), Gaps = 33/246 (13%) Query: 124 GRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFK-- 181 GR + ++ N G +N++ P+ R+ + D+ + I+ K Sbjct: 11 GRRKVQVSYVIRDEVEKYNRNG----VNALQLDPALN-RLFTAGRDSIIRIWSVNQHKQD 65 Query: 182 -FKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSG 240 + ++ HT +V+ + +G S D T+ ++N G F +L+ H Sbjct: 66 PYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKG-----FCMSTLR--THKD 118 Query: 241 SVFGLTWSPDGTKIASASADKTIKIWNVATLKV----EKTIPVGT---------RIEDQQ 287 V L ++ D +ASA D+ I +W+V TL T+ + + Q Sbjct: 119 YVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQ 178 Query: 288 LGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGH 347 LG I +VS S + +P + GH + AL + DG S ++G Sbjct: 179 LGTI-----IVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGT 233 Query: 348 INSWDI 353 I W + Sbjct: 234 IRLWSL 239 Score = 38.9 bits (89), Expect = 0.007, Method: Compositional matrix adjust. Identities = 54/251 (21%), Positives = 91/251 (36%), Gaps = 63/251 (25%) Query: 163 IISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN---- 218 +IS S D TV ++ ST H +V ++ Y D L AS G D I L++ Sbjct: 90 LISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTL 149 Query: 219 -------------GVDGTKTGVFE---------------------------DDSLKNVAH 238 + G K ++ +K H Sbjct: 150 TALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGH 209 Query: 239 SGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALV 298 + +V L + DGT+ S S+D TI++W++ + T R+ D+ + + A Sbjct: 210 TDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATY----RVHDEGVWALQVNDAFT 265 Query: 299 SISANG------FINFVNPELGSIDQVRYGHNKA---ITALSSSAD-GKTLFSADAEGHI 348 + + G + NP++ +V KA L SAD ++ A + + Sbjct: 266 HVYSGGRDRKIYCTDLRNPDI----RVLICEEKAPVLKMELDRSADPPPAIWVATTKSTV 321 Query: 349 NSWDISTGISN 359 N W + GI N Sbjct: 322 NKWTLK-GIHN 331 Score = 38.1 bits (87), Expect = 0.011, Method: Compositional matrix adjust. Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 1/60 (1%) Query: 550 RLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNS-VIWLNETTIVSAGQDSNIKFWN 608 RL T D+ + +W++N+ P I H VN V+ N T++SA D+ +K WN Sbjct: 44 RLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWN 103 >6BX3-A nrPDB Length = 314 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 39/151 (25%), Positives = 78/151 (51%), Gaps = 11/151 (7%) Query: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLV--A 508 ++C +S D QF+A+ Q + +Y ++ +VS+ H + + +S +G + + Sbjct: 15 ATCAKISPDGQFLAIT-QGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATAS 73 Query: 509 TDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKP 568 D S ++I S + L HT + HTA V ++++ L T S+D S+ +W+ Sbjct: 74 DDFSVEIIHLS----YGLLHT--FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG 127 Query: 569 SDHPIIIKGAHAMSSVNSVIWLNETTIVSAG 599 S I AH+ + V+ + +N+++I+S+G Sbjct: 128 SLMKTI--SAHSEAVVSVDVPMNDSSILSSG 156 Score = 37.0 bits (84), Expect = 0.025, Method: Compositional matrix adjust. Identities = 39/182 (21%), Positives = 70/182 (38%), Gaps = 16/182 (8%) Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 H + + ++PDG A+ D ++ + + G+ + H+ V LT++ Sbjct: 53 HARPFSELCWSPDGQCIATASDDFSVEIIH----LSYGLLH----TFIGHTAPVISLTFN 104 Query: 249 PDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINF 308 G + ++S D++IKIW+ + KTI + + L S S +G I Sbjct: 105 RKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRI 164 Query: 309 VNPELGSI--------DQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNR 360 + E G D R I+ + S + + L +G + WD G R Sbjct: 165 FDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVR 224 Query: 361 VF 362 F Sbjct: 225 TF 226 Score = 35.0 bits (79), Expect = 0.098, Method: Compositional matrix adjust. Identities = 44/183 (24%), Positives = 78/183 (42%), Gaps = 19/183 (10%) Query: 180 FKFKSTFGEHTKF-VHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAH 238 F+F + G + +PDG A T G I++Y+ T + +H Sbjct: 1 FQFVTPVGTQNGLKATCAKISPDGQFLAITQG-LNILIYDINRRTVSQTLV------TSH 53 Query: 239 SGSVFGLTWSPDGTKIASASADKTIKI----WNVATLKVEKTIPVGTRIEDQQLGIIWTK 294 + L WSPDG IA+AS D +++I + + + T PV + +++ +++T Sbjct: 54 ARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTS 113 Query: 295 QALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSA-DGKTLFSADAEGHINSWDI 353 SI +N GS+ + H++A+ ++ D L S +G I +D Sbjct: 114 SMDESIKIWDTLN------GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA 167 Query: 354 STG 356 TG Sbjct: 168 ETG 170 >5NZU-C nrPDB Length = 905 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 26/110 (23%), Positives = 52/110 (47%), Gaps = 9/110 (8%) Query: 163 IISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN-GVD 221 +++G+DD + +F + F H+ ++ + +P ++ D I L++ Sbjct: 72 VVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKK 131 Query: 222 GTKTGVFEDDSLKNVAHSGSVFGLTWSP-DGTKIASASADKTIKIWNVAT 270 + + VFE H+ V + +P D + ASAS D+TIK+W + + Sbjct: 132 WSCSQVFE-------GHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGS 174 Score = 35.4 bits (80), Expect = 0.078, Method: Compositional matrix adjust. Identities = 29/98 (29%), Positives = 47/98 (47%), Gaps = 9/98 (9%) Query: 126 ERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKST 185 +R ++ + T L G A+ ++ F P P II+GS+D TV I+ ++ +ST Sbjct: 208 DRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPI-IITGSEDGTVRIWHSSTYRLEST 266 Query: 186 FG---EHTKFVHSVRYNPDGSLFASTGGD-GTIVLYNG 219 E V S+R GS + G D G+I++ G Sbjct: 267 LNYGMERVWCVASLR----GSNNVALGYDEGSIIVKLG 300 >5OQL-X nrPDB Length = 630 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 42/94 (44%), Gaps = 7/94 (7%) Query: 184 STFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVF 243 T+ H K V+ + DG + G D +V+YN D F H +V Sbjct: 240 KTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAF-------TQHRDAVT 292 Query: 244 GLTWSPDGTKIASASADKTIKIWNVATLKVEKTI 277 GL + ++ S S D+T+K+W++ L +T+ Sbjct: 293 GLAFRRGTNQLYSCSKDRTVKVWSLDELAYVETL 326 Score = 37.7 bits (86), Expect = 0.015, Method: Compositional matrix adjust. Identities = 31/134 (23%), Positives = 58/134 (43%), Gaps = 8/134 (5%) Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV-HPAEITSVAFSNNGAFLVATDQS 512 V S D +FV GG D ++ VY + A + +K H +T +AF L + + Sbjct: 252 VKASQDGKFVVTGGADKRLVVY--NAADLKPIKAFTQHRDAVTGLAFRRGTNQLYSCSKD 309 Query: 513 RKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHP 572 R V +S+ ELA+ + H ++ + ++ G+ D + W + P + Sbjct: 310 RTVKVWSLD---ELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARYWKV--PEESQ 364 Query: 573 IIIKGAHAMSSVNS 586 ++ +G S N+ Sbjct: 365 LVFRGGGEGGSSNT 378 >6EOJ-D nrPDB Length = 470 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 49/232 (21%), Positives = 94/232 (40%), Gaps = 33/232 (14%) Query: 162 RIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVD 221 R++ + +++ F F++ H V +++Y+ D S DG I ++ Sbjct: 107 RLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP-- 164 Query: 222 GTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIP--- 278 + V E D+ AH+ S+ + +S + +K + S D +KIWN + K E+ + Sbjct: 165 -NFSMVKEIDA----AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHH 219 Query: 279 --VGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSI--DQVRYGHNKAITALSSSA 334 V + ++G+I S S + + +P G+ +++ H T + Sbjct: 220 WDVKSCDWHPEMGLI------ASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTK 273 Query: 335 DGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSW 386 G L + IS S RVF D+ +M + + D T+ W Sbjct: 274 -GNLLMA-----------ISKDKSCRVF-DIRYSMKELMCVRDETDYMTLEW 312 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 59/287 (20%), Positives = 108/287 (37%), Gaps = 52/287 (18%) Query: 27 TPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRI 85 TP G ++ + +++ S T + H T K S + SGD G ++I Sbjct: 102 TPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKI 161 Query: 86 WDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTG 145 W + ++K + ++D+++ S + + + ++ F G L+G Sbjct: 162 WQPNFS--MVKEIDAAHTESIRDMAFSSNDSKFVTCSD--DNILKIWNFSNGKQERVLSG 217 Query: 146 QARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSV---RYNP-D 201 + S D+ P I S S DN V +++ + + KF H+V R+ P Sbjct: 218 HHWDVKSCDWHPEMGL-IASASKDNLVKLWDP---RSGNCISSILKFKHTVLKTRFQPTK 273 Query: 202 GSLFASTGGDGTIVLYN----------GVDGTKTGVFE--------------DDSLKNV- 236 G+L + D + +++ D T E D SLK+ Sbjct: 274 GNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFD 333 Query: 237 --------------AHSGSVFGLTWSPDGTKIASASADKTIKIWNVA 269 AH + L+++P G A+A+ D+TI+ W A Sbjct: 334 LLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA 380 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 41/205 (20%), Positives = 77/205 (37%), Gaps = 35/205 (17%) Query: 244 GLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA-----LV 298 + W+P+G ++ A+ +WN ++ E T ++ + K + ++ Sbjct: 98 AIQWTPEGRRLVVATYSGEFSLWNASSFTFE------TLMQAHDSAVTTMKYSHDSDWMI 151 Query: 299 SISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGIS 358 S A+G I P + ++ H ++I ++ S++ + + + W+ S G Sbjct: 152 SGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQ 211 Query: 359 NRVFP---------DVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDS---SKAV 406 RV D H M G+ ++ D WD P G+ + S K Sbjct: 212 ERVLSGHHWDVKSCDWHPEM--GLIASASKDNLVKLWD------PRSGNCISSILKFKHT 263 Query: 407 ANKLSSQP----LGLAVSADGDIAV 427 K QP L +A+S D V Sbjct: 264 VLKTRFQPTKGNLLMAISKDKSCRV 288 Score = 38.1 bits (87), Expect = 0.012, Method: Compositional matrix adjust. Identities = 50/253 (19%), Positives = 90/253 (35%), Gaps = 18/253 (7%) Query: 142 NLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFV-HSVRYNP 200 NL + ++D P +R D + + P KF K V ++++ P Sbjct: 52 NLVVEPETSYTIDIMPPNAYR----GRDRVINL----PSKFTHLSSNKVKHVIPAIQWTP 103 Query: 201 DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASAD 260 +G G L+N T + + AH +V + +S D + S AD Sbjct: 104 EGRRLVVATYSGEFSLWNASSFTFETLMQ-------AHDSAVTTMKYSHDSDWMISGDAD 156 Query: 261 KTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVR 320 IKIW + K I + + V+ S + + N G ++V Sbjct: 157 GMIKIWQ-PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVL 215 Query: 321 YGHNKAITALSSSADGKTLFSADAEGHINSWDISTG-ISNRVFPDVHATMITGIKTTSKG 379 GH+ + + + + SA + + WD +G + + H + T + T Sbjct: 216 SGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGN 275 Query: 380 DLFTVSWDDHLKV 392 L +S D +V Sbjct: 276 LLMAISKDKSCRV 288 Score = 35.8 bits (81), Expect = 0.051, Method: Compositional matrix adjust. Identities = 17/57 (29%), Positives = 27/57 (47%) Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGL 245 H K + S+ YNP G +FA+ D TI + ++D + N +G FG+ Sbjct: 349 HDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGI 405 Score = 32.7 bits (73), Expect = 0.44, Method: Compositional matrix adjust. Identities = 26/113 (23%), Positives = 50/113 (44%), Gaps = 8/113 (7%) Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLV--ATDQ 511 + S+D ++ G D + +++ + + V E+ H I +AFS+N + V + D Sbjct: 141 MKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDA-AHTESIRDMAFSSNDSKFVTCSDDN 199 Query: 512 SRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWN 564 K+ +S + + W V W P+ +A+ S DN V +W+ Sbjct: 200 ILKIWNFSNGKQERVLSGHHW-----DVKSCDWHPEMGLIASASKDNLVKLWD 247 Score = 31.6 bits (70), Expect = 1.1, Method: Compositional matrix adjust. Identities = 25/106 (23%), Positives = 48/106 (45%), Gaps = 8/106 (7%) Query: 509 TDQSRKVIPYSVANNFELAHTNSWTF------HTAKVACVSWSPDNVRLATGSLDNSVIV 562 T + R+++ + + F L + +S+TF H + V + +S D+ + +G D + + Sbjct: 102 TPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKI 161 Query: 563 WNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 W N I AH S + N++ V+ D+ +K WN Sbjct: 162 WQPNFSMVKEI--DAAHTESIRDMAFSSNDSKFVTCSDDNILKIWN 205 >5FVM-C nrPDB Length = 303 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 60/293 (20%), Positives = 118/293 (40%), Gaps = 29/293 (9%) Query: 75 ASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLF 134 AS +R W+ T + TI V + S+ K +AA G HV L+ Sbjct: 6 ASAGYDHTIRFWEAL--TGVCSRTIQHADSQVNRLEITSDKKYLAAAGHL-----HVRLY 58 Query: 135 DTGTSNGN----LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHT 190 D ++N N G + S+ F+ + ++S S+D T+ +++ + + +H Sbjct: 59 DIRSNNPNPVSSFEGHKGNVTSIAFQQENRW-MVSSSEDGTIKVWDVRSPSVQRNY-KHN 116 Query: 191 KFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVF--EDDSLKNVAHSGSVFGLTWS 248 V+ V +P+ S DG I +++ + T ED++ + L+ + Sbjct: 117 APVNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNT--------PLQSLSVA 168 Query: 249 PDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK-----QALVSISAN 303 DG+ + + + +W + T+ T+ + I + L + SA+ Sbjct: 169 SDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSAD 228 Query: 304 GFINFVNPELG-SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIST 355 N E ++ GH + + + SAD L +A ++ ++ WD+ST Sbjct: 229 HTARVWNIEDNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLST 281 Score = 38.9 bits (89), Expect = 0.007, Method: Compositional matrix adjust. Identities = 62/279 (22%), Positives = 112/279 (40%), Gaps = 42/279 (15%) Query: 254 IASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFI------- 306 +ASA D TI+ W T +TI + D Q+ + ++A G + Sbjct: 5 LASAGYDHTIRFWEALTGVCSRTI----QHADSQVNRLEITSDKKYLAAAGHLHVRLYDI 60 Query: 307 --NFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPD 364 N NP + S + GH +T+++ + + + S+ +G I WD+ + R + Sbjct: 61 RSNNPNP-VSSFE----GHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK- 114 Query: 365 VHATMITGIKT-TSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQ---PL-GLAV 419 H + + ++G+L + D ++++ G N+L+ + PL L+V Sbjct: 115 -HNAPVNEVAIHPNQGELISCDQDGNIRIWDLG------ENQCTNQLTPEDNTPLQSLSV 167 Query: 420 SADGDIAVAA-----CYKHIAIYSHGKLTEVPISYNSS------CVALSNDKQFVAVGGQ 468 ++DG + VA CY + T P++ S V LS D + +A Sbjct: 168 ASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSA 227 Query: 469 DSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLV 507 D V+ + E H + AFS + A+LV Sbjct: 228 DHTARVWNIEDNYQLETTLDGHQRWVWDCAFSADSAYLV 266 Score = 34.7 bits (78), Expect = 0.12, Method: Compositional matrix adjust. Identities = 20/76 (26%), Positives = 39/76 (51%), Gaps = 5/76 (6%) Query: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSV-IWLNET 593 H V +++ +N + + S D ++ VW++ PS + + + VN V I N+ Sbjct: 74 HKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPS----VQRNYKHNAPVNEVAIHPNQG 129 Query: 594 TIVSAGQDSNIKFWNV 609 ++S QD NI+ W++ Sbjct: 130 ELISCDQDGNIRIWDL 145 Score = 32.7 bits (73), Expect = 0.42, Method: Compositional matrix adjust. Identities = 43/213 (20%), Positives = 79/213 (37%), Gaps = 16/213 (7%) Query: 184 STFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVF 243 S+F H V S+ + + S+ DGTI +++ V +N H+ V Sbjct: 69 SSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWD--------VRSPSVQRNYKHNAPVN 120 Query: 244 GLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISAN 303 + P+ ++ S D I+IW++ + + Q L + LV+ + Sbjct: 121 EVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNK 180 Query: 304 GFINFV-----NPELGSIDQVRY--GHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 G +V + + +++ V H K IT + SAD K L + A+ W+I Sbjct: 181 GNC-YVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDN 239 Query: 357 ISNRVFPDVHATMITGIKTTSKGDLFTVSWDDH 389 D H + ++ + DH Sbjct: 240 YQLETTLDGHQRWVWDCAFSADSAYLVTACSDH 272 Score = 31.6 bits (70), Expect = 1.2, Method: Compositional matrix adjust. Identities = 50/250 (20%), Positives = 92/250 (36%), Gaps = 55/250 (22%) Query: 412 SQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISY------NSSCVALSNDKQFVAV 465 SQ L +++D AA + H+ +Y P+S N + +A + +++ Sbjct: 33 SQVNRLEITSDKKYLAAAGHLHVRLYDIRSNNPNPVSSFEGHKGNVTSIAFQQENRWMVS 92 Query: 466 GGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQ-------------- 511 +D + V+ + SV + H A + VA N L++ DQ Sbjct: 93 SSEDGTIKVWDVRSPSVQ--RNYKHNAPVNEVAIHPNQGELISCDQDGNIRIWDLGENQC 150 Query: 512 SRKVIP--------YSVANNFELA----------------HTNSWTF--------HTAKV 539 + ++ P SVA++ + HT++ T HT + Sbjct: 151 TNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYI 210 Query: 540 ACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAG 599 V S D LAT S D++ VWN+ + G H + + +V+A Sbjct: 211 TRVLLSADVKNLATCSADHTARVWNIEDNYQLETTLDG-HQRWVWDCAFSADSAYLVTAC 269 Query: 600 QDSNIKFWNV 609 D ++ W++ Sbjct: 270 SDHYVRLWDL 279 >4YCZ-A nrPDB Length = 876 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 32/110 (29%), Positives = 54/110 (49%), Gaps = 11/110 (10%) Query: 162 RIISGSDDNTVAIFE--GPPFKFKSTFGEHTKFVHSVRY-NPD-GSLFASTGGDGTIVLY 217 R+ + S D T+ IFE G + T H V V + +P G++ AS G DG ++++ Sbjct: 32 RLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIW 91 Query: 218 NGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD--GTKIASASADKTIKI 265 ++G +F+ H SV ++WSP G +A AS+D + + Sbjct: 92 RELNGAWQRIFD-----FALHKASVNVVSWSPHEAGCLLACASSDGNVSV 136 Score = 35.0 bits (79), Expect = 0.086, Method: Compositional matrix adjust. Identities = 51/208 (24%), Positives = 82/208 (39%), Gaps = 54/208 (25%) Query: 441 KLTEVPISYNSS--CVALSNDK--QFVAVGGQDSKVHVYK-LSGASVSEVKTIVHPAEIT 495 +LTE ++ + CV+ ++ K +A G D KV +++ L+GA +H A + Sbjct: 53 RLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVN 112 Query: 496 SVAFS--NNGAFLV--ATDQSRKVIPYSVANNFELAHTNSWTF-----HTAKVACVSWSP 546 V++S G L ++D + V+ + NSW H V VSW+P Sbjct: 113 VVSWSPHEAGCLLACASSDGNVSVLEF---------RDNSWEHSIFHAHGLGVNSVSWAP 163 Query: 547 -----------------DNVRLATGSLDNSVIVW------NMNKPSDHPIIIKGAHAMSS 583 N R TG DN++ +W N K P+ H Sbjct: 164 ATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLT---GHT-DW 219 Query: 584 VNSVIW----LNETTIVSAGQDSNIKFW 607 V V W L ++ I SA +D ++ W Sbjct: 220 VRDVAWSPTVLQKSYIASASEDRTVRIW 247 Score = 33.5 bits (75), Expect = 0.25, Method: Compositional matrix adjust. Identities = 35/130 (26%), Positives = 54/130 (41%), Gaps = 33/130 (25%) Query: 163 IISGSDDNTVAIFEGPPFKFKSTFGEHTKF------VHSVRYNP---DGSL--------- 204 + S D V++ E F+ EH+ F V+SV + P GS+ Sbjct: 125 LACASSDGNVSVLE-----FRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKS 179 Query: 205 -----FASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP---DGTKIAS 256 F + G D + ++ T T E + L H+ V + WSP + IAS Sbjct: 180 TGNRRFVTGGSDNALKIWAYDPATNTYKLEREPL--TGHTDWVRDVAWSPTVLQKSYIAS 237 Query: 257 ASADKTIKIW 266 AS D+T++IW Sbjct: 238 ASEDRTVRIW 247 Score = 31.2 bits (69), Expect = 1.3, Method: Compositional matrix adjust. Identities = 26/104 (25%), Positives = 47/104 (45%), Gaps = 4/104 (3%) Query: 509 TDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVR---LATGSLDNSVIVWNM 565 +D + K+ Y A N T HT V V+WSP ++ +A+ S D +V +W Sbjct: 190 SDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTS 249 Query: 566 NKPSDHPIIIKGAHAMSSVNSVIW-LNETTIVSAGQDSNIKFWN 608 + + K + ++V V W L+ + ++G D+ + W Sbjct: 250 DPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLWK 293 Score = 31.2 bits (69), Expect = 1.5, Method: Compositional matrix adjust. Identities = 39/169 (23%), Positives = 66/169 (39%), Gaps = 17/169 (10%) Query: 162 RIISGSDDNTVAIFEGPP----FKF-KSTFGEHTKFVHSVRYNP---DGSLFASTGGDGT 213 R ++G DN + I+ P +K + HT +V V ++P S AS D T Sbjct: 184 RFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRT 243 Query: 214 IVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKV 273 + ++ + K + +V+ ++WS G +A++ D + +W LK Sbjct: 244 VRIWTSDPANPLQW----NCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLWK-ENLKG 298 Query: 274 E----KTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQ 318 E KTI G Q + A GF+ + + IDQ Sbjct: 299 EWECVKTIEEGGGGSGGGGQAKGPTQPEQASPAKGFVKWPYQQRPKIDQ 347 >2AQ5-A nrPDB Length = 402 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 33/111 (29%), Positives = 55/111 (49%), Gaps = 13/111 (11%) Query: 163 IISGSDDNTVAIFEGP------PFKFKS-TFGEHTKFVHSVRYNPDG-SLFASTGGDGTI 214 I SGS+D TV ++E P P + T HTK V V ++P ++ S G D I Sbjct: 97 IASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVI 156 Query: 215 VLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKI 265 ++++ GT V +L H +++ + WS DG I ++ DK +++ Sbjct: 157 LVWDV--GTGAAVL---TLGPDVHPDTIYSVDWSRDGALICTSCRDKRVRV 202 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 30/84 (35%), Positives = 43/84 (51%), Gaps = 11/84 (13%) Query: 535 HTAKVACVSWSP--DNVRLATGSLDNSVIVWNMNK-----PSDHPIIIKGAHAMSSVNSV 587 HTA V ++W P DNV +A+GS D +V+VW + P P+I H V V Sbjct: 80 HTAPVLDIAWCPHNDNV-IASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHT-KRVGIV 137 Query: 588 IW--LNETTIVSAGQDSNIKFWNV 609 W + ++SAG D+ I W+V Sbjct: 138 AWHPTAQNVLLSAGCDNVILVWDV 161 >5L9T-R nrPDB Length = 493 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 54/240 (22%), Positives = 90/240 (37%), Gaps = 44/240 (18%) Query: 68 SPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRER 127 S G A G G V+IWD + + + + V ++W++E ++++ R Sbjct: 238 SERGNLVAVGTHKGFVQIWDAAAGKKL--SMLEGHTARVGALAWNAE--QLSSGSRDRMI 293 Query: 128 FGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFG 187 S L G + + + + + SG +DN + ++ + Sbjct: 294 LQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQL-LASGGNDNKLLVWNHSSLSPVQQYT 352 Query: 188 EHTKFVHSVRYNP-DGSLFASTGG--DGTIVLYNGVDGT-----KTG------------- 226 EH V ++ ++P L AS GG D I +N + G TG Sbjct: 353 EHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHAN 412 Query: 227 --------------VFEDDSLKNVA----HSGSVFGLTWSPDGTKIASASADKTIKIWNV 268 V++ SL VA HS V L SPDG I + + D+T++ WNV Sbjct: 413 ELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/174 (24%), Positives = 83/174 (47%), Gaps = 14/174 (8%) Query: 441 KLTEVPISYNS-SCVALSNDKQFVAVGGQDSKVHVYKLS-GASVSEVKTIVHPAEITSVA 498 +L ++ + +S + V S VAVG V ++ + G +S ++ H A + ++A Sbjct: 221 RLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEG--HTARVGALA 278 Query: 499 FSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDN 558 + N L + + R ++ + L H +V + WS D+ LA+G DN Sbjct: 279 W--NAEQLSSGSRDRMILQRDI-RTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDN 335 Query: 559 SVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWL-NETTIVSAG---QDSNIKFWN 608 ++VWN + S P+ H +++V ++ W ++ ++++G D I+FWN Sbjct: 336 KLLVWNHSSLS--PVQQYTEH-LAAVKAIAWSPHQHGLLASGGGTADRCIRFWN 386 Score = 35.0 bits (79), Expect = 0.098, Method: Compositional matrix adjust. Identities = 55/258 (21%), Positives = 98/258 (37%), Gaps = 41/258 (15%) Query: 241 SVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGT-RIEDQQLGIIWTKQALVS 299 SV + WS G +A + ++IW+ A K + T R+ + W + L S Sbjct: 231 SVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVG----ALAWNAEQLSS 286 Query: 300 ISANGFI---NFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 S + I + P L S +++ GH + + L S D + L S + + W+ S+ Sbjct: 287 GSRDRMILQRDIRTPPLQSERRLQ-GHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSL 345 Query: 357 ISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLK-VVPAGGSGVDSSKAVANKLSSQPL 415 + + + H + I +W H ++ +GG D N L+ QPL Sbjct: 346 SPVQQYTE-HLAAVKAI-----------AWSPHQHGLLASGGGTADRCIRFWNTLTGQPL 393 Query: 416 GLAVSADGDIAVAACYKH--------------IAIYSHGKLTEVPI----SYNSSCVALS 457 + + A KH I ++ + LT+V SY +A+S Sbjct: 394 Q-CIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMS 452 Query: 458 NDKQFVAVGGQDSKVHVY 475 D + + G D + + Sbjct: 453 PDGEAIVTGAGDETLRFW 470 Score = 33.1 bits (74), Expect = 0.34, Method: Compositional matrix adjust. Identities = 47/238 (19%), Positives = 88/238 (36%), Gaps = 62/238 (26%) Query: 166 GSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKT 225 G+ V I++ K S HT V ++ +N + S+G ++L + +T Sbjct: 247 GTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ---LSSGSRDRMILQRDI---RT 300 Query: 226 GVFEDDSLKNVAHSGSVFGLTWSPDGTKIAS----------------------------- 256 + + + H V GL WS D +AS Sbjct: 301 PPLQSER-RLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVK 359 Query: 257 ----------------ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA--LV 298 +AD+ I+ WN T + + I G+++ + W+K A LV Sbjct: 360 AIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQV----CNLAWSKHANELV 415 Query: 299 S---ISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 S S N + + P L + ++ GH+ + L+ S DG+ + + + + W++ Sbjct: 416 STHGYSQNQILVWKYPSLTQVAKL-TGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472 Score = 30.0 bits (66), Expect = 3.4, Method: Compositional matrix adjust. Identities = 37/178 (20%), Positives = 63/178 (35%), Gaps = 21/178 (11%) Query: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKR 117 H + K S ASG + +W+ + + + + T + VK I+W Sbjct: 312 HRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHL--AAVKAIAWSPHQHG 369 Query: 118 IAAVGEGRE----RFGHVF------LFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGS 167 + A G G RF + DTG+ NL A V G Sbjct: 370 LLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVS---------THGY 420 Query: 168 DDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKT 225 N + +++ P + H+ V + +PDG + GD T+ +N T++ Sbjct: 421 SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRS 478 >6CB1-s nrPDB Length = 569 Score = 42.0 bits (97), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 41/158 (25%), Positives = 63/158 (39%), Gaps = 28/158 (17%) Query: 126 ERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFE----GPPFK 181 +R+ ++ L AR ++ +D P R +I+ S D V + P+K Sbjct: 421 QRYVRIYDLSQQILVKKLLPGARWLSKIDIHP-RGDNLIASSFDKRVLWHDLDLASTPYK 479 Query: 182 FKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKN------ 235 T H K V SV ++ LF+S DGTI +++ DD +KN Sbjct: 480 ---TLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFH-------ATVYDDMMKNPMIVPL 529 Query: 236 -------VAHSGSVFGLTWSPDGTKIASASADKTIKIW 266 V +S V W P + SA AD T ++W Sbjct: 530 KKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 567 Score = 33.5 bits (75), Expect = 0.29, Method: Compositional matrix adjust. Identities = 14/46 (30%), Positives = 22/46 (47%) Query: 54 IYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTI 99 IY H + PSG + A+G G VR+W+ + +TT+ Sbjct: 194 IYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTL 239 Score = 29.6 bits (65), Expect = 3.7, Method: Compositional matrix adjust. Identities = 12/33 (36%), Positives = 19/33 (57%) Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVAT 270 H G V L+ P G +A+ S D T+++W + T Sbjct: 198 HKGKVRTLSIDPSGLWLATGSDDGTVRVWEILT 230 >5K19-A nrPDB Length = 569 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 39/133 (29%), Positives = 56/133 (42%), Gaps = 6/133 (4%) Query: 467 GQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFEL 526 G+ VH K +K V + AFS +G FL Q + ++ ++ EL Sbjct: 196 GESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNF-DSVEL 254 Query: 527 AHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNS 586 T F + CV WSPD + TG D+ V VW+ D +I +G S V+ Sbjct: 255 HGTMKSYF--GGLLCVCWSPDGKYIVTGGEDDLVTVWSF---VDCRVIARGHGHKSWVSV 309 Query: 587 VIWLNETTIVSAG 599 V + TT V G Sbjct: 310 VAFDPYTTSVEEG 322 Score = 38.5 bits (88), Expect = 0.009, Method: Compositional matrix adjust. Identities = 20/78 (25%), Positives = 33/78 (42%), Gaps = 11/78 (14%) Query: 198 YNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHS--GSVFGLTWSPDGTKIA 255 ++PDG A DG + ++N F+ L S G + + WSPDG I Sbjct: 228 FSPDGKFLACVSQDGFLRVFN---------FDSVELHGTMKSYFGGLLCVCWSPDGKYIV 278 Query: 256 SASADKTIKIWNVATLKV 273 + D + +W+ +V Sbjct: 279 TGGEDDLVTVWSFVDCRV 296 >6ID0-T nrPDB Length = 514 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 40/162 (24%), Positives = 71/162 (43%), Gaps = 16/162 (9%) Query: 131 VFLFD--TGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGE 188 + L+D G + LT +++ +V P R + SGS DN + ++ P F Sbjct: 354 IRLWDLVAGKTRVTLTNHKKSVRAVVLHP-RHYTFASGSPDN-IKQWKFPDGSFIQNLSG 411 Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGS------V 242 H ++++ N DG L S +GT+ L++ G + + GS + Sbjct: 412 HNAIINTLTVNSDGVLV-SGADNGTMHLWDWRTG-----YNFQRVHAAVQPGSLDSESGI 465 Query: 243 FGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIE 284 F + +++ +A ADKTIK++ E+T PV + E Sbjct: 466 FACAFDQSESRLLTAEADKTIKVYREDDTATEETHPVSWKPE 507 Score = 37.4 bits (85), Expect = 0.019, Method: Compositional matrix adjust. Identities = 57/266 (21%), Positives = 109/266 (40%), Gaps = 21/266 (7%) Query: 126 ERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKST 185 +R ++ +G +LTG + V P+ + S +D V ++ K Sbjct: 225 DRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPY-LFSCGEDKQVKCWDLEYNKVIRH 283 Query: 186 FGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA-HSGSVFG 244 + H V+ + +P + + D T +++ V S+ ++ H+ +V Sbjct: 284 YHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWD--------VRTKASVHTLSGHTNAVAT 335 Query: 245 LTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQ--ALVSISA 302 + +I + S D TI++W++ K T+ T + ++ + S S Sbjct: 336 VRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTL---TNHKKSVRAVVLHPRHYTFASGSP 392 Query: 303 NGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVF 362 + + P+ GS Q GHN I L+ ++DG + AD G ++ WD TG + F Sbjct: 393 DNIKQWKFPD-GSFIQNLSGHNAIINTLTVNSDGVLVSGAD-NGTMHLWDWRTGYN---F 447 Query: 363 PDVHATMITGIKTTSKGDLFTVSWDD 388 VHA + G + G +F ++D Sbjct: 448 QRVHAAVQPGSLDSESG-IFACAFDQ 472 Score = 33.5 bits (75), Expect = 0.31, Method: Compositional matrix adjust. Identities = 19/78 (24%), Positives = 38/78 (48%), Gaps = 4/78 (5%) Query: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT 594 H V C++ P N TGS D ++ +W++ + + + +S+V VI + Sbjct: 203 HLGWVRCIAVEPGNQWFVTGSADRTIKIWDL---ASGKLKLSLTGHISTVRGVIVSTRSP 259 Query: 595 -IVSAGQDSNIKFWNVPF 611 + S G+D +K W++ + Sbjct: 260 YLFSCGEDKQVKCWDLEY 277 Score = 32.0 bits (71), Expect = 0.85, Method: Compositional matrix adjust. Identities = 29/122 (23%), Positives = 52/122 (42%), Gaps = 3/122 (2%) Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA- 296 H G V + P + SAD+TIKIW++A+ K++ + + I + I+ T+ Sbjct: 203 HLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLK--LSLTGHISTVRGVIVSTRSPY 260 Query: 297 LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 L S + + + E + + +GH A+ L L + + WD+ T Sbjct: 261 LFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTK 320 Query: 357 IS 358 S Sbjct: 321 AS 322 >6C0F-s nrPDB Length = 807 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/158 (26%), Positives = 65/158 (41%), Gaps = 28/158 (17%) Query: 126 ERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFE----GPPFK 181 +R+ ++ L AR ++ +D P R +I+ S D V + P+K Sbjct: 659 QRYVRIYDLSQQILVKKLLPGARWLSKIDIHP-RGDNLIASSFDKRVLWHDLDLASTPYK 717 Query: 182 FKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKN------ 235 T H K V SV ++ LF+S DGTI +++ V+ DD +KN Sbjct: 718 ---TLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHAT------VY-DDMMKNPMIVPL 767 Query: 236 -------VAHSGSVFGLTWSPDGTKIASASADKTIKIW 266 V +S V W P + SA AD T ++W Sbjct: 768 KKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 33.5 bits (75), Expect = 0.26, Method: Compositional matrix adjust. Identities = 14/46 (30%), Positives = 22/46 (47%) Query: 54 IYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTI 99 IY H + PSG + A+G G VR+W+ + +TT+ Sbjct: 432 IYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTL 477 Score = 30.0 bits (66), Expect = 3.3, Method: Compositional matrix adjust. Identities = 12/33 (36%), Positives = 19/33 (57%) Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVAT 270 H G V L+ P G +A+ S D T+++W + T Sbjct: 436 HKGKVRTLSIDPSGLWLATGSDDGTVRVWEILT 468 Score = 28.5 bits (62), Expect = 7.8, Method: Compositional matrix adjust. Identities = 15/42 (35%), Positives = 22/42 (52%) Query: 524 FELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM 565 F + + + H KV +S P + LATGS D +V VW + Sbjct: 425 FPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEI 466 >6EM1-m nrPDB Length = 807 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/158 (26%), Positives = 65/158 (41%), Gaps = 28/158 (17%) Query: 126 ERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFE----GPPFK 181 +R+ ++ L AR ++ +D P R +I+ S D V + P+K Sbjct: 659 QRYVRIYDLSQQILVKKLLPGARWLSKIDIHP-RGDNLIASSFDKRVLWHDLDLASTPYK 717 Query: 182 FKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKN------ 235 T H K V SV ++ LF+S DGTI +++ V+ DD +KN Sbjct: 718 ---TLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHAT------VY-DDMMKNPMIVPL 767 Query: 236 -------VAHSGSVFGLTWSPDGTKIASASADKTIKIW 266 V +S V W P + SA AD T ++W Sbjct: 768 KKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 33.1 bits (74), Expect = 0.32, Method: Compositional matrix adjust. Identities = 14/46 (30%), Positives = 22/46 (47%) Query: 54 IYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTI 99 IY H + PSG + A+G G VR+W+ + +TT+ Sbjct: 432 IYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTL 477 Score = 30.0 bits (66), Expect = 3.4, Method: Compositional matrix adjust. Identities = 12/33 (36%), Positives = 19/33 (57%) Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVAT 270 H G V L+ P G +A+ S D T+++W + T Sbjct: 436 HKGKVRTLSIDPSGLWLATGSDDGTVRVWEILT 468 Score = 28.5 bits (62), Expect = 9.1, Method: Compositional matrix adjust. Identities = 14/31 (45%), Positives = 18/31 (58%) Query: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNM 565 H KV +S P + LATGS D +V VW + Sbjct: 436 HKGKVRTLSIDPSGLWLATGSDDGTVRVWEI 466 >4AEZ-A nrPDB Length = 401 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 64/269 (23%), Positives = 105/269 (39%), Gaps = 54/269 (20%) Query: 56 TEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSES 115 T+ S K S G + + G +G V I+D T + T+ V +SW+ Sbjct: 131 TDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTKL--RTMAGHQARVGCLSWN--- 185 Query: 116 KRIAAVGEGRERFGHVFLFDTGTSN---GNLTGQARAMNSVDFKPSRPFRIISGSDDNTV 172 + + + G R G + D +N G L G + + + ++ S ++ SG +DN V Sbjct: 186 RHVLSSGS---RSGAIHHHDVRIANHQIGTLQGHSSEVCGLAWR-SDGLQLASGGNDNVV 241 Query: 173 AIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGG---DGTIVLYNGVDGTKTGV-- 227 I++ K T H V +V + P S +TGG D I +N G + Sbjct: 242 QIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVD 301 Query: 228 ----------------------FEDDSL-----------KNV---AHSGSVFGLTWSPDG 251 F D++L K V AH V SPDG Sbjct: 302 AGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDG 361 Query: 252 TKIASASADKTIKIWNVAT-LKVEKTIPV 279 +++A++D+ +K W V V++ IP+ Sbjct: 362 RILSTAASDENLKFWRVYDGDHVKRPIPI 390 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 44/173 (25%), Positives = 84/173 (48%), Gaps = 16/173 (9%) Query: 442 LTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV-HPAEITSVAFS 500 L E S + V S+D F++VG + V +Y + S ++++T+ H A + +++ Sbjct: 128 LAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVE--SQTKLRTMAGHQARVGCLSW- 184 Query: 501 NNGAFLVATDQSRKVIPYSVA-NNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNS 559 N L + +S + + V N ++ H+++V ++W D ++LA+G DN Sbjct: 185 -NRHVLSSGSRSGAIHHHDVRIANHQIGTLQG---HSSEVCGLAWRSDGLQLASGGNDNV 240 Query: 560 VIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLN-ETTIVSAG---QDSNIKFWN 608 V +W+ S P K H ++V +V W ++ +++ G D I FWN Sbjct: 241 VQIWDAR--SSIPKFTKTNHN-AAVKAVAWCPWQSNLLATGGGTMDKQIHFWN 290 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 38/181 (20%), Positives = 73/181 (40%), Gaps = 20/181 (11%) Query: 185 TFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFG 244 T H+ V + + DG AS G D + +++ H+ +V Sbjct: 212 TLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIP-------KFTKTNHNAAVKA 264 Query: 245 LTWSPDGTKIAS---ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSIS 301 + W P + + + + DK I WN AT T+ G+++ +IW+ + +S Sbjct: 265 VAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQVT----SLIWSPHSKEIMS 320 Query: 302 ANGFIN-----FVNPELGSIDQVRY-GHNKAITALSSSADGKTLFSADAEGHINSWDIST 355 +GF + + G QV H+ + + S DG+ L +A ++ ++ W + Sbjct: 321 THGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYD 380 Query: 356 G 356 G Sbjct: 381 G 381 Score = 32.0 bits (71), Expect = 0.72, Method: Compositional matrix adjust. Identities = 32/150 (21%), Positives = 66/150 (44%), Gaps = 20/150 (13%) Query: 214 IVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKV 273 + ++N G+ + + E D VA + WS DG+ ++ + + I++V + Sbjct: 115 VYVWNADSGSVSALAETDESTYVA------SVKWSHDGSFLSVGLGNGLVDIYDVESQTK 168 Query: 274 EKTIPVGTRIEDQQLGII-WTKQALVSISANGFIN-----FVNPELGSIDQVRYGHNKAI 327 +T+ ++G + W + L S S +G I+ N ++G++ GH+ + Sbjct: 169 LRTMAG----HQARVGCLSWNRHVLSSGSRSGAIHHHDVRIANHQIGTLQ----GHSSEV 220 Query: 328 TALSSSADGKTLFSADAEGHINSWDISTGI 357 L+ +DG L S + + WD + I Sbjct: 221 CGLAWRSDGLQLASGGNDNVVQIWDARSSI 250 Score = 31.6 bits (70), Expect = 1.0, Method: Compositional matrix adjust. Identities = 34/161 (21%), Positives = 75/161 (46%), Gaps = 10/161 (6%) Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVAT---D 510 +A +D +A GG D+ V ++ + +S+ + H A + +VA+ + L+AT Sbjct: 223 LAWRSDGLQLASGGNDNVVQIWD-ARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGT 281 Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLAT--GSLDNSVIVWNMNKP 568 +++ ++ A + ++ ++V + WSP + + + G DN++ +W+ + Sbjct: 282 MDKQIHFWNAATGARVNTVDA----GSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSS 337 Query: 569 SDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 + AH + S + + + +A D N+KFW V Sbjct: 338 GLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRV 378 >4J0X-A nrPDB Length = 451 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 41/156 (26%), Positives = 68/156 (43%), Gaps = 13/156 (8%) Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV---HPAEITSVAFSNNGAFLVATD 510 VA S D ++V GG+D K+ V+ S S+S VK I E+ S+AF N L A+ Sbjct: 120 VAASPDGKYVVTGGRDRKLIVW--STESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYASC 177 Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 K+ YS+ N F + H V +S + G+ D + ++W + P + Sbjct: 178 ADFKIRTYSI-NQF--SQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWKI--PDE 232 Query: 571 HPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKF 606 + +G + W+ E G+D +K+ Sbjct: 233 TRLTFRGGDEPQKLLRR-WMKEN--AKEGEDGEVKY 265 Score = 31.6 bits (70), Expect = 1.2, Method: Compositional matrix adjust. Identities = 23/100 (23%), Positives = 45/100 (45%), Gaps = 3/100 (3%) Query: 237 AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA 296 H + + SPDG + + D+ + +W+ +L K IP R + L + + K + Sbjct: 112 GHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDR-RGEVLSLAFRKNS 170 Query: 297 --LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSA 334 L + A+ I + S ++ YGH+ + +S+ A Sbjct: 171 DQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALA 210 >3ACP-A nrPDB Length = 417 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 31/143 (21%), Positives = 60/143 (41%), Gaps = 9/143 (6%) Query: 129 GHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGE 188 GH FLF+T +G+ + +VD + R I G+ + + + + F + + Sbjct: 75 GHDFLFNTIIRDGSKMLKRADYTAVDTAKLQMRRFILGTTEGDIKVLDSN-FNLQREIDQ 133 Query: 189 -HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW 247 H + +++ P G S+ D + +++ DG+ + H +V + Sbjct: 134 AHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTL-------IGHRATVTDIAI 186 Query: 248 SPDGTKIASASADKTIKIWNVAT 270 G + SAS D TI++W T Sbjct: 187 IDRGRNVLSASLDGTIRLWECGT 209 Score = 32.3 bits (72), Expect = 0.64, Method: Compositional matrix adjust. Identities = 21/72 (29%), Positives = 35/72 (48%), Gaps = 1/72 (1%) Query: 237 AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA 296 AH + L + P G + S+S D +KIW+V +T+ +G R + II + Sbjct: 134 AHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTL-IGHRATVTDIAIIDRGRN 192 Query: 297 LVSISANGFINF 308 ++S S +G I Sbjct: 193 VLSASLDGTIRL 204 >6BX3-B nrPDB Length = 412 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 25/97 (25%), Positives = 49/97 (50%), Gaps = 4/97 (4%) Query: 173 AIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDS 232 A+ + P K T E+ ++++P G A +G +V+Y+ +D + + Sbjct: 9 AVLKEHPEKLTHTI-ENPLRTECLQFSPCGDYLALGCANGALVIYD-MDTFRPICVPGNM 66 Query: 233 LKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVA 269 L AH + + WSPDG + ++S D +IK+W+++ Sbjct: 67 LG--AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLS 101 Score = 36.2 bits (82), Expect = 0.038, Method: Compositional matrix adjust. Identities = 24/85 (28%), Positives = 40/85 (47%), Gaps = 3/85 (3%) Query: 487 TIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFE--LAHTNSWTFHTAKVACVSW 544 TI +P + FS G +L + ++ Y + + F N H + ++W Sbjct: 21 TIENPLRTECLQFSPCGDYLALGCANGALVIYDM-DTFRPICVPGNMLGAHVRPITSIAW 79 Query: 545 SPDNVRLATGSLDNSVIVWNMNKPS 569 SPD L T S D S+ +W+++KPS Sbjct: 80 SPDGRLLLTSSRDWSIKLWDLSKPS 104 >4AV8-A nrPDB Length = 339 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 25/80 (31%), Positives = 40/80 (50%), Gaps = 4/80 (5%) Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 H V VR N G + A+ DGT++ V T GV + + + + S+ + WS Sbjct: 178 HANPVKMVRLNRKGDMVATCSQDGTLI---RVFQTDNGVLVREFRRGLDRT-SIIDMRWS 233 Query: 249 PDGTKIASASADKTIKIWNV 268 PDG+K+A S T+ ++ V Sbjct: 234 PDGSKLAVVSDKWTLHVFEV 253 >5WLC-SG nrPDB Length = 573 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 41/156 (26%), Positives = 68/156 (43%), Gaps = 13/156 (8%) Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV---HPAEITSVAFSNNGAFLVATD 510 VA S D ++V GG+D K+ V+ S S+S VK I E+ S+AF N L A+ Sbjct: 242 VAASPDGKYVVTGGRDRKLIVW--STESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYASC 299 Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 K+ YS+ N F + H V +S + G+ D + ++W + P + Sbjct: 300 ADFKIRTYSI-NQF--SQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWKI--PDE 354 Query: 571 HPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKF 606 + +G + W+ E G+D +K+ Sbjct: 355 TRLTFRGGDEPQKLLRR-WMKEN--AKEGEDGEVKY 387 Score = 31.2 bits (69), Expect = 1.4, Method: Compositional matrix adjust. Identities = 23/99 (23%), Positives = 45/99 (45%), Gaps = 3/99 (3%) Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA- 296 H + + SPDG + + D+ + +W+ +L K IP R + L + + K + Sbjct: 235 HYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDR-RGEVLSLAFRKNSD 293 Query: 297 -LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSA 334 L + A+ I + S ++ YGH+ + +S+ A Sbjct: 294 QLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALA 332 >4OWR-A nrPDB Length = 339 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 15/33 (45%), Positives = 25/33 (75%) Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVAT 270 H+G V + WS DG+K+ +AS DKT K+W++++ Sbjct: 56 HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSS 88 Score = 37.4 bits (85), Expect = 0.020, Method: Compositional matrix adjust. Identities = 35/157 (22%), Positives = 62/157 (39%), Gaps = 8/157 (5%) Query: 315 SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFP-DVHATMITGI 373 +I + + H + + S DG +F+A + WD+S+ + ++ D I I Sbjct: 48 TIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWI 107 Query: 374 KTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQ----PLGLAVSADGDIAVAA 429 K + + T SWD LK S + + P+ + +A+ + V Sbjct: 108 KAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIV-- 165 Query: 430 CYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVG 466 Y+ S + E P+ + CVA+ DKQ G Sbjct: 166 -YQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTG 201 Score = 37.0 bits (84), Expect = 0.027, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 53/109 (48%), Gaps = 8/109 (7%) Query: 503 GAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIV 562 G FL+A + V + V ++ + + HT V V WS D ++ T S D + + Sbjct: 25 GNFLIAGSWANDVRCWEVQDSGQTI-PKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKM 83 Query: 563 WNMNKPSDHPIIIKGAHAMSSVNSVIWL---NETTIVSAGQDSNIKFWN 608 W+++ S+ I I A + V ++ W+ N + +++ D +KFW+ Sbjct: 84 WDLS--SNQAIQI--AQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWD 128 >6EMK-B nrPDB Length = 303 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 41/194 (21%), Positives = 83/194 (42%), Gaps = 13/194 (6%) Query: 163 IISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN--GV 220 ++S D+T+ +E T V+ + D L A T G + LY+ Sbjct: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLA-TAGHQNVRLYDIRTT 63 Query: 221 DGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVG 280 + FE H G+V +++ D + ++S D TIK+W+V + + + Sbjct: 64 NPNPVASFE-------GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHN 116 Query: 281 TRIEDQQLGIIWTKQALVSISANGFINFVNP-ELGSIDQVRYGHNKAITALSSSADGKTL 339 + ++ I + L+S +G I + E Q+ + ++ +LS ++DG L Sbjct: 117 APV--NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 Query: 340 FSADAEGHINSWDI 353 +A+ +G+ W++ Sbjct: 175 AAANTKGNCYVWEM 188 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 34/127 (26%), Positives = 61/127 (48%), Gaps = 10/127 (7%) Query: 486 KTIVHP-AEITSVAFSNNGAFLV-ATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVS 543 +TI H +++ + +N+ L A Q+ ++ N +A S+ H V VS Sbjct: 26 RTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVA---SFEGHRGNVTSVS 82 Query: 544 WSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNS-VIWLNETTIVSAGQDS 602 + DN + T S D ++ VW++ PS I + + VN VI N+ ++S +D Sbjct: 83 FQQDNRWMVTSSEDGTIKVWDVRSPS----IPRNYKHNAPVNEVVIHPNQGELISCDRDG 138 Query: 603 NIKFWNV 609 NI+ W++ Sbjct: 139 NIRIWDL 145 Score = 37.4 bits (85), Expect = 0.021, Method: Compositional matrix adjust. Identities = 58/274 (21%), Positives = 108/274 (39%), Gaps = 32/274 (11%) Query: 254 IASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGF----INFV 309 + SA D TI+ W T +TI + + +L I K+ L + I Sbjct: 5 LVSAGYDHTIRFWEALTGVCSRTIQ-HSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTT 63 Query: 310 NPE-LGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHAT 368 NP + S + GH +T++S D + + ++ +G I WD+ + R + +A Sbjct: 64 NPNPVASFE----GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKH-NAP 118 Query: 369 MITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVA 428 + + ++G+L + D ++++ G + + S Q L +A +DG + A Sbjct: 119 VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMA--SDGSMLAA 176 Query: 429 A-----CY----------KHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVH 473 A CY H+ + + I+ + LS+D + +A D Sbjct: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITR----ILLSSDVKHLATCSADHTAR 232 Query: 474 VYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLV 507 V+ + E H + AFS + A+LV Sbjct: 233 VWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLV 266 Score = 33.5 bits (75), Expect = 0.24, Method: Compositional matrix adjust. Identities = 55/279 (19%), Positives = 105/279 (37%), Gaps = 52/279 (18%) Query: 80 HGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTS 139 H NVR++D T + G V +S+ +++ + E G + ++D + Sbjct: 52 HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSED----GTIKVWDVRSP 107 Query: 140 NGNLTGQARA-MNSVDFKPSRPFRIISGSDDNTVAIFE-GPPFKFKSTFGEHTKFVHSVR 197 + + A +N V P++ +IS D + I++ G E + S+ Sbjct: 108 SIPRNYKHNAPVNEVVIHPNQG-ELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLS 166 Query: 198 YNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASA 257 DGS+ A+ G ++ + T + + K AHS + + S D +A+ Sbjct: 167 MASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVT-KFRAHSTYITRILLSSDVKHLATC 225 Query: 258 SADKTIKIWNV-ATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSI 316 SAD T ++W++ K+E T+ Sbjct: 226 SADHTARVWSIDDDFKLETTLD-------------------------------------- 247 Query: 317 DQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIST 355 GH + + + SAD L +A ++ ++ WD+ST Sbjct: 248 -----GHQRWVWDCAFSADSAYLVTASSDHYVRLWDLST 281 Score = 32.3 bits (72), Expect = 0.70, Method: Compositional matrix adjust. Identities = 35/157 (22%), Positives = 64/157 (40%), Gaps = 25/157 (15%) Query: 76 SGDVHGNVRIWD--TTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFL 133 S D GN+RIWD Q TH L P ++ +S S+ +AA G+ ++ Sbjct: 133 SCDRDGNIRIWDLGENQCTHQL---TPEDDTSLQSLSMASDGSMLAAANTK----GNCYV 185 Query: 134 FDTGTSNGNLTGQARAMNSVDFKPSRPF--RIISGSD---------DNTVAIFE-GPPFK 181 ++ N T + F+ + RI+ SD D+T ++ FK Sbjct: 186 WEM----PNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFK 241 Query: 182 FKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN 218 ++T H ++V ++ D + + D + L++ Sbjct: 242 LETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 Score = 30.8 bits (68), Expect = 2.0, Method: Compositional matrix adjust. Identities = 25/145 (17%), Positives = 61/145 (42%), Gaps = 4/145 (2%) Query: 468 QDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELA 527 +D + ++ L + T + S++ +++G+ L A + + + N+ + + Sbjct: 136 RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDAS 195 Query: 528 H---TNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSV 584 H + H+ + + S D LAT S D++ VW+++ + G H Sbjct: 196 HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDG-HQRWVW 254 Query: 585 NSVIWLNETTIVSAGQDSNIKFWNV 609 + + +V+A D ++ W++ Sbjct: 255 DCAFSADSAYLVTASSDHYVRLWDL 279 >5UZ7-B nrPDB Length = 351 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 69/320 (21%), Positives = 118/320 (36%), Gaps = 66/320 (20%) Query: 81 GNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSN 140 G + IWD+ T + IP+ S V ++ + S A G G + ++ T N Sbjct: 88 GKLIIWDSYTTNKV--HAIPLRSSWVMTCAY-APSGNYVACG-GLDNICSIYNLKTREGN 143 Query: 141 ----GNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSV 196 L G ++ F +I++ S D T A+++ + +TF HT V S+ Sbjct: 144 VRVSRELAGHTGYLSCCRFLDDN--QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSL 201 Query: 197 RYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIAS 256 PD LF S D + L++ +G F H + + + P+G A+ Sbjct: 202 SLAPDTRLFVSGACDASAKLWDVREGMCRQTF-------TGHESDINAICFFPNGNAFAT 254 Query: 257 ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSI 316 S D T +++++ DQ+L Sbjct: 255 GSDDATCRLFDLRA--------------DQEL---------------------------- 272 Query: 317 DQVRYGHNK---AITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGI 373 + Y H+ IT++S S G+ L + + + N WD V H ++ + Sbjct: 273 --MTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAG-HDNRVSCL 329 Query: 374 KTTSKG-DLFTVSWDDHLKV 392 T G + T SWD LK+ Sbjct: 330 GVTDDGMAVATGSWDSFLKI 349 Score = 38.5 bits (88), Expect = 0.009, Method: Compositional matrix adjust. Identities = 32/133 (24%), Positives = 54/133 (40%), Gaps = 10/133 (7%) Query: 137 GTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKF--VH 194 G TG +N++ F P+ +GSDD T +F+ + T+ + Sbjct: 227 GMCRQTFTGHESDINAICFFPNGN-AFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 285 Query: 195 SVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKI 254 SV ++ G L + D +++ + + GV H V L + DG + Sbjct: 286 SVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL-------AGHDNRVSCLGVTDDGMAV 338 Query: 255 ASASADKTIKIWN 267 A+ S D +KIWN Sbjct: 339 ATGSWDSFLKIWN 351 Score = 36.2 bits (82), Expect = 0.048, Method: Compositional matrix adjust. Identities = 42/221 (19%), Positives = 79/221 (35%), Gaps = 28/221 (12%) Query: 179 PFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAH 238 + + T H ++++ + D L S DG +++++ K Sbjct: 55 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIP-------LR 107 Query: 239 SGSVFGLTWSPDGTKIASASADKTIKIWNVAT----LKVEKTIPVGTR-------IEDQQ 287 S V ++P G +A D I+N+ T ++V + + T ++D Q Sbjct: 108 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ 167 Query: 288 LGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGH 347 + V+ S + + E G GH + +LS + D + S + Sbjct: 168 I---------VTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDAS 218 Query: 348 INSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDD 388 WD+ G+ + F H + I I G+ F DD Sbjct: 219 AKLWDVREGMCRQTFTG-HESDINAICFFPNGNAFATGSDD 258 Score = 35.4 bits (80), Expect = 0.082, Method: Compositional matrix adjust. Identities = 28/104 (26%), Positives = 47/104 (45%), Gaps = 8/104 (7%) Query: 464 AVGGQDSKVHVYKLSGASVSEVKTIVHP---AEITSVAFSNNGAFLVATDQSRKVIPYSV 520 A G D+ ++ L E+ T H ITSV+FS +G L+A +V Sbjct: 253 ATGSDDATCRLFDLRADQ--ELMTYSHDNIICGITSVSFSKSGRLLLA---GYDDFNCNV 307 Query: 521 ANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWN 564 + + H +V+C+ + D + +ATGS D+ + +WN Sbjct: 308 WDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 351 >5K0Y-T nrPDB Length = 329 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 19/84 (22%), Positives = 42/84 (50%), Gaps = 7/84 (8%) Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 H + + ++YN +G L + D + ++ V+G + G + + H+G+V+ + Sbjct: 9 HERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTY-------MGHTGAVWCVDAD 61 Query: 249 PDGTKIASASADKTIKIWNVATLK 272 D + + SAD + ++W+ T K Sbjct: 62 WDTKHVLTGSADNSCRLWDCETGK 85 Score = 31.6 bits (70), Expect = 0.93, Method: Compositional matrix adjust. Identities = 21/75 (28%), Positives = 31/75 (41%), Gaps = 3/75 (4%) Query: 490 HPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNV 549 H IT + ++ G L + V + N L ++ HT V CV D Sbjct: 9 HERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLG---TYMGHTGAVWCVDADWDTK 65 Query: 550 RLATGSLDNSVIVWN 564 + TGS DNS +W+ Sbjct: 66 HVLTGSADNSCRLWD 80 >6E29-D nrPDB Length = 345 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 63/290 (21%), Positives = 113/290 (38%), Gaps = 51/290 (17%) Query: 196 VRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIA 255 VR+N G AS DGT+V++ D GV + K HS ++ L+WS G + Sbjct: 31 VRFNRKGDFLASGRVDGTVVIW---DLETMGV----ARKLRGHSKNITSLSWSRCGRYLL 83 Query: 256 SASADKTIKIWNVATLKVEKTIPVGTRIEDQQL----------GIIWTKQALVSISANGF 305 SA + +W++ K + + + +L + + LV I+ Sbjct: 84 SACQGWKVILWDLQDGKRYREVRFRAPVYGAELHPWNHHQFAAALFEDQPMLVDITEPVE 143 Query: 306 INFVNPELGSI-----------DQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIS 354 + +V P + Q + TA+ +A G L + +G +N D Sbjct: 144 VRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNIIDAR 203 Query: 355 TGISNRVFPD-VHATMITGIKTTSKGDLFTVSWDDHLK---VVP-AGGSGVDSS------ 403 T ++ + + + +IT ++ T G V+ D + +VP + +D Sbjct: 204 T--REIIYSEKIASGIITTLRLTESGRELLVNAQDRIIRTFIVPNLSAADLDPDTIQLPL 261 Query: 404 ----KAVANKLSSQPLGLAVSADGDIAVAACYKHIAIY----SHGKLTEV 445 + V N+LS +A SA G+ A+ Y + +Y HG L + Sbjct: 262 EHKFQDVVNRLSWN--HVAFSATGEYVAASTYNNHELYIWERGHGSLVRM 309 Score = 36.6 bits (83), Expect = 0.034, Method: Compositional matrix adjust. Identities = 22/73 (30%), Positives = 38/73 (52%), Gaps = 1/73 (1%) Query: 450 NSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVAT 509 +S+CV + F+A G D V ++ L V+ K H ITS+++S G +L++ Sbjct: 27 HSTCVRFNRKGDFLASGRVDGTVVIWDLETMGVAR-KLRGHSKNITSLSWSRCGRYLLSA 85 Query: 510 DQSRKVIPYSVAN 522 Q KVI + + + Sbjct: 86 CQGWKVILWDLQD 98 >3F3P-A nrPDB Length = 351 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 29/81 (35%), Positives = 41/81 (50%), Gaps = 5/81 (6%) Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW- 247 H VH V Y+ G A+ D I ++ +D + DS + AH S+ + W Sbjct: 10 HDDLVHDVVYDFYGRHVATCSSDQHIKVFK-LDKDTSNWELSDSWR--AHDSSIVAIDWA 66 Query: 248 SPD-GTKIASASADKTIKIWN 267 SP+ G IASAS DKT+K+W Sbjct: 67 SPEYGRIIASASYDKTVKLWE 87 Score = 31.2 bits (69), Expect = 1.5, Method: Compositional matrix adjust. Identities = 27/133 (20%), Positives = 56/133 (42%), Gaps = 14/133 (10%) Query: 141 GNLTGQARAMNSVDFKPS--RPFRIIS-GSDDNTVAIFE----GPPFKFKSTFGEHTKFV 193 L G + S+ + PS R +++I+ G D + IF+ P + + F Sbjct: 208 AKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFD 267 Query: 194 HSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTK 253 +S + D + + + L + + +D H+G V+ ++W+ GT Sbjct: 268 NSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDD-------HNGEVWSVSWNLTGTI 320 Query: 254 IASASADKTIKIW 266 ++SA D +++W Sbjct: 321 LSSAGDDGKVRLW 333 >6QDV-o nrPDB Length = 513 Score = 38.9 bits (89), Expect = 0.007, Method: Compositional matrix adjust. Identities = 66/297 (22%), Positives = 113/297 (38%), Gaps = 57/297 (19%) Query: 322 GHNKAITALSSSADGKTLFSADAEGHINSWDISTG-----ISNRVFPDVHATMITGIKTT 376 GH+KA+ + + G SA + ++ WD TG +NR P + Sbjct: 264 GHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVP----YCVKFNPDE 319 Query: 377 SKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAI 436 K +LF +G+ K V + S G+I V +H+ Sbjct: 320 DKQNLFV--------------AGMSDKKIVQWDIRS----------GEI-VQEYDRHLGA 354 Query: 437 YSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPA--EI 494 + T V + N V+ S+DK + V D V + K I P+ + Sbjct: 355 VN----TIVFVDENRRFVSTSDDKS-LRVWEWDIPV-----------DFKYIAEPSMHSM 398 Query: 495 TSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFH-TAKVAC-VSWSPDNVRLA 552 +V S NG +L +++ + N F L + H A AC V +SPD + Sbjct: 399 PAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVI 458 Query: 553 TGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT-IVSAGQDSNIKFWN 608 +G + + +W+ + AH + +V +ET+ +++ G D IK W+ Sbjct: 459 SGDGNGKLNIWDWKTTKLYSRF--KAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 513 Score = 37.0 bits (84), Expect = 0.023, Method: Compositional matrix adjust. Identities = 47/194 (24%), Positives = 82/194 (42%), Gaps = 32/194 (16%) Query: 189 HTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKN-VAHSGSVFGLT 246 HTK V +VR P G L S D I L+ V G E L+ + HS +V + Sbjct: 221 HTKGVSAVRLFPLSGHLLLSCSMDCKIKLWE-VYG------ERRCLRTFIGHSKAVRDIC 273 Query: 247 WSPDGTKIASASADKTIKIWNVATLKV-----EKTIPVGTRI---EDQQ----LGIIWTK 294 ++ GT+ SA+ D+ +K+W+ T + + +P + ED+Q G+ K Sbjct: 274 FNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKK 333 Query: 295 QALVSISANGFINFVNPELGSIDQVRY-GHNKAITALSSSADGKTLFSADAEGHINSWDI 353 I + + + LG+++ + + N+ S++D K+L + WDI Sbjct: 334 IVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFV---STSDDKSL-------RVWEWDI 383 Query: 354 STGISNRVFPDVHA 367 P +H+ Sbjct: 384 PVDFKYIAEPSMHS 397 Score = 34.7 bits (78), Expect = 0.12, Method: Compositional matrix adjust. Identities = 29/135 (21%), Positives = 57/135 (42%), Gaps = 12/135 (8%) Query: 162 RIISGSDDNTVAIFEGP-PFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLY--- 217 R +S SDD ++ ++E P FK + +V +P+G A D I+++ Sbjct: 366 RFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQ 425 Query: 218 NGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTI 277 N K +F+ + +G + +SPD + + S + + IW+ T K+ Sbjct: 426 NRFRLNKKKIFKGHMV-----AGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRF 480 Query: 278 PVGTRIEDQQLGIIW 292 ++ +G +W Sbjct: 481 KAHDKV---CIGAVW 492 >5N4A-A nrPDB Length = 771 Score = 38.5 bits (88), Expect = 0.010, Method: Compositional matrix adjust. Identities = 33/114 (28%), Positives = 56/114 (49%), Gaps = 18/114 (15%) Query: 163 IISGSDDNTVAIFE--GPPFKFKSTFGEHTKFVH-----SVRYNPDGS-LFASTGGDGTI 214 + + SDD T+ + G P + ST + +H S + G+ +FA DG++ Sbjct: 28 LFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKTQAGGTDVFAVACTDGSV 87 Query: 215 VLYNGVDGTKTGVFEDDSLKNV-AHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 + ++TG E K++ H G+ L WS DGT +A+A D ++KIW+ Sbjct: 88 KIL-----SRTGRVE----KSIEGHKGACISLRWSYDGTALATAGEDGSVKIWS 132 Score = 37.4 bits (85), Expect = 0.018, Method: Compositional matrix adjust. Identities = 39/143 (27%), Positives = 64/143 (44%), Gaps = 9/143 (6%) Query: 425 IAVAACYKHIAIYSH-GKLTEVPISYNSSCVAL--SNDKQFVAVGGQDSKVHVYKLSGAS 481 AVA + I S G++ + + +C++L S D +A G+D V ++ +G Sbjct: 78 FAVACTDGSVKILSRTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKIWSRNGML 137 Query: 482 VSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVAC 541 S + P + S+ ++ + L S VI S+++N A N+W H V Sbjct: 138 RSTLAQADSP--VYSIVWAYDCDQLCYCTGSNVVIK-SLSSN---AKQNAWKAHDGVVLK 191 Query: 542 VSWSPDNVRLATGSLDNSVIVWN 564 V WSP N + TG D VW+ Sbjct: 192 VDWSPINHLIITGGEDCKYKVWD 214 Score = 36.6 bits (83), Expect = 0.034, Method: Compositional matrix adjust. Identities = 45/194 (23%), Positives = 82/194 (42%), Gaps = 24/194 (12%) Query: 66 KTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGR 125 + S G A+ G+V+IW +L++T+ PV I W + ++ Sbjct: 111 RWSYDGTALATAGEDGSVKIWSRN---GMLRSTLAQADSPVYSIVWAYDCDQLCYCT--- 164 Query: 126 ERFGHVFLFDTGTSNGNLTGQAR---AMNSVDFKPSRPFRIISGSDDNTVAIFEG-PPFK 181 G + + +SN + VD+ P II+G +D +++ Sbjct: 165 ---GSNVVIKSLSSNAKQNAWKAHDGVVLKVDWSPINHL-IITGGEDCKYKVWDSFGRLL 220 Query: 182 FKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGS 241 F+S ++ V SV + P G LFA GG T+ L + + + + +D+ GS Sbjct: 221 FQSGLFDYP--VTSVAWAPSGELFA-VGGFNTLQLCDRMGWAYSKIHLNDT-------GS 270 Query: 242 VFGLTWSPDGTKIA 255 + L+W+ D T++A Sbjct: 271 IMTLSWTADSTQLA 284 Score = 30.4 bits (67), Expect = 2.2, Method: Compositional matrix adjust. Identities = 23/69 (33%), Positives = 32/69 (46%), Gaps = 6/69 (8%) Query: 538 KVACVS--WSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTI 595 K AC+S WS D LAT D SV +W+ N + A A S V S++W + Sbjct: 104 KGACISLRWSYDGTALATAGEDGSVKIWSRNGMLRSTL----AQADSPVYSIVWAYDCDQ 159 Query: 596 VSAGQDSNI 604 + SN+ Sbjct: 160 LCYCTGSNV 168 >5YZG-W nrPDB Length = 579 Score = 37.7 bits (86), Expect = 0.013, Method: Compositional matrix adjust. Identities = 66/297 (22%), Positives = 113/297 (38%), Gaps = 57/297 (19%) Query: 322 GHNKAITALSSSADGKTLFSADAEGHINSWDISTG-----ISNRVFPDVHATMITGIKTT 376 GH+KA+ + + G SA + ++ WD TG +NR P + Sbjct: 330 GHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVP----YCVKFNPDE 385 Query: 377 SKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAI 436 K +LF +G+ K V + S G+I V +H+ Sbjct: 386 DKQNLFV--------------AGMSDKKIVQWDIRS----------GEI-VQEYDRHLGA 420 Query: 437 YSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPA--EI 494 + T V + N V+ S+DK + V D V + K I P+ + Sbjct: 421 VN----TIVFVDENRRFVSTSDDKS-LRVWEWDIPV-----------DFKYIAEPSMHSM 464 Query: 495 TSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFH-TAKVAC-VSWSPDNVRLA 552 +V S NG +L +++ + N F L + H A AC V +SPD + Sbjct: 465 PAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVI 524 Query: 553 TGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT-IVSAGQDSNIKFWN 608 +G + + +W+ + AH + +V +ET+ +++ G D IK W+ Sbjct: 525 SGDGNGKLNIWDWKTTKLYSRF--KAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579 Score = 37.4 bits (85), Expect = 0.020, Method: Compositional matrix adjust. Identities = 47/194 (24%), Positives = 82/194 (42%), Gaps = 32/194 (16%) Query: 189 HTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKN-VAHSGSVFGLT 246 HTK V +VR P G L S D I L+ V G E L+ + HS +V + Sbjct: 287 HTKGVSAVRLFPLSGHLLLSCSMDCKIKLWE-VYG------ERRCLRTFIGHSKAVRDIC 339 Query: 247 WSPDGTKIASASADKTIKIWNVATLKV-----EKTIPVGTRI---EDQQ----LGIIWTK 294 ++ GT+ SA+ D+ +K+W+ T + + +P + ED+Q G+ K Sbjct: 340 FNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKK 399 Query: 295 QALVSISANGFINFVNPELGSIDQVRY-GHNKAITALSSSADGKTLFSADAEGHINSWDI 353 I + + + LG+++ + + N+ S++D K+L + WDI Sbjct: 400 IVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFV---STSDDKSL-------RVWEWDI 449 Query: 354 STGISNRVFPDVHA 367 P +H+ Sbjct: 450 PVDFKYIAEPSMHS 463 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 29/135 (21%), Positives = 57/135 (42%), Gaps = 12/135 (8%) Query: 162 RIISGSDDNTVAIFEGP-PFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLY--- 217 R +S SDD ++ ++E P FK + +V +P+G A D I+++ Sbjct: 432 RFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQ 491 Query: 218 NGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTI 277 N K +F+ + +G + +SPD + + S + + IW+ T K+ Sbjct: 492 NRFRLNKKKIFKGHMV-----AGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRF 546 Query: 278 PVGTRIEDQQLGIIW 292 ++ +G +W Sbjct: 547 KAHDKV---CIGAVW 558 >5M89-A nrPDB Length = 329 Score = 37.7 bits (86), Expect = 0.014, Method: Compositional matrix adjust. Identities = 36/145 (24%), Positives = 64/145 (44%), Gaps = 24/145 (16%) Query: 162 RIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVD 221 +++ G+ V +++ + +TF H V + +P G + AS G D + V Y+ Sbjct: 104 KVVIGTAKGWVKVYDAG--RESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLET 161 Query: 222 GTKTGV-FEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVG 280 G + + D +L A + PDG A+ + I +++ TL+ ++ P+G Sbjct: 162 GERVARGYADAALTTCA---------FHPDGNLFAAGTQTGHILVFHTTTLEQAESFPLG 212 Query: 281 TRIEDQQLGIIWTKQALVSISANGF 305 T I QAL + S NGF Sbjct: 213 TPI-----------QAL-AFSENGF 225 >4U1E-I nrPDB Length = 347 Score = 37.7 bits (86), Expect = 0.015, Method: Compositional matrix adjust. Identities = 45/217 (20%), Positives = 84/217 (38%), Gaps = 25/217 (11%) Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 H + + V+YN +G L S D + ++ ++G + G + H+G+++ + Sbjct: 9 HERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLD-------GHTGTIWSIDVD 61 Query: 249 PDGTKIASASADKTIKIWNVATLKVEKT----IPVGTRIEDQQLGIIWTKQALVSISANG 304 + SAD +IK+W+V+ + T +PV R+E G + + G Sbjct: 62 CFTKYCVTGSADYSIKLWDVSNGQCVATWKSPVPV-KRVEFSPCGNYFLAILDNVMKNPG 120 Query: 305 FINFVNPELGSIDQ-------------VRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 IN E S + + A T S GK + + +G I+ + Sbjct: 121 SINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKY 180 Query: 352 DISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDD 388 D+S D+H I+ ++ + F S D Sbjct: 181 DVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRD 217 Score = 36.2 bits (82), Expect = 0.048, Method: Compositional matrix adjust. Identities = 31/138 (22%), Positives = 64/138 (46%), Gaps = 9/138 (6%) Query: 468 QDSKVH-VYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFEL 526 +DS H + K+S + ++ T T +S G +++A + K+ Y V+NN+E Sbjct: 129 RDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVSNNYE- 187 Query: 527 AHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNS 586 + +S H ++ + +SPD T S D + + +++ ++K +N+ Sbjct: 188 -YVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQ----VLKKYETDCPLNT 242 Query: 587 VIW--LNETTIVSAGQDS 602 + L E I+ GQ++ Sbjct: 243 AVITPLKEFIILGGGQEA 260 >4BZK-B nrPDB Length = 297 Score = 37.7 bits (86), Expect = 0.015, Method: Compositional matrix adjust. Identities = 29/118 (24%), Positives = 52/118 (44%), Gaps = 11/118 (9%) Query: 156 KPSRPFRIISGSDDNTVAIF----EGPPFKFKSTFGEHTKFVHSVRYNPD---GSLFAST 208 K SR F ++G DN V I+ + + +ST H+ +V V ++P S AS Sbjct: 168 KESRKF--VTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASV 225 Query: 209 GGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIW 266 D T +++ + G ++ LK ++ +WS G +A + D + +W Sbjct: 226 SQDRTCIIW--TQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 30.8 bits (68), Expect = 2.0, Method: Compositional matrix adjust. Identities = 51/213 (23%), Positives = 84/213 (39%), Gaps = 40/213 (18%) Query: 83 VRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGN 142 ++I++ TH L T+ GPV + W + + G V ++ NG Sbjct: 33 IKIFEVEGETHKLIDTLTGHEGPVWRVDW--AHPKFGTILASCSYDGKVLIWK--EENGR 88 Query: 143 LTG------QARAMNSVDFKPSR--PFRIISGSDDNTVAIFEGPPFKFKST-----FGEH 189 + + ++NSV + P P +++ S D V++ E FK T H Sbjct: 89 WSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS-DGKVSVVE---FKENGTTSPIIIDAH 144 Query: 190 TKFVHSVRYNP-----DGS--------LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV 236 V+S + P DG F + G D + ++ +T V E +L+ Sbjct: 145 AIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLE-STLE-- 201 Query: 237 AHSGSVFGLTWSPD---GTKIASASADKTIKIW 266 HS V + WSP + +AS S D+T IW Sbjct: 202 GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 >4XYI-A nrPDB Length = 430 Score = 37.4 bits (85), Expect = 0.017, Method: Compositional matrix adjust. Identities = 32/134 (23%), Positives = 60/134 (44%), Gaps = 13/134 (9%) Query: 150 MNSVDFKPSRPFRIISGSDDNTVAIFEG--PPFKFKS-TFGEHTKFVHSVRYNP-DGSLF 205 +N + F + S SDD T+ I + P S H + V+ V +NP + L Sbjct: 238 VNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLL 297 Query: 206 ASTGGDGTIVLYNGVD-GTKTGVFEDDSLKNVAHSGSVFGLTWSP-DGTKIASASADKTI 263 A+ D T+ L++ + E H V+ + WSP D + ++S D+ + Sbjct: 298 ATASADHTVALWDLRRLNQRLHTLE-------GHEDEVYNVQWSPHDEPILVTSSTDRRV 350 Query: 264 KIWNVATLKVEKTI 277 +W+++ + E+T+ Sbjct: 351 CVWDLSKIGEEQTV 364 Score = 37.4 bits (85), Expect = 0.020, Method: Compositional matrix adjust. Identities = 28/132 (21%), Positives = 60/132 (45%), Gaps = 10/132 (7%) Query: 145 GQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFK-STFGEHTKFVHSVRYNP-DG 202 + +N V F P + + + S D+TVA+++ + T H V++V+++P D Sbjct: 279 AHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPHDE 338 Query: 203 SLFASTGGDGTIVLYNGVDGTKTGVFEDDS-------LKNVAHSGSVFGLTWSPDGT-KI 254 + ++ D + +++ + ED + H+ V L+W+P+ + Sbjct: 339 PILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVL 398 Query: 255 ASASADKTIKIW 266 AS + D ++IW Sbjct: 399 ASLADDNILQIW 410 Score = 29.3 bits (64), Expect = 4.9, Method: Compositional matrix adjust. Identities = 23/90 (25%), Positives = 45/90 (50%), Gaps = 6/90 (6%) Query: 184 STFGEHTKFVHSVRYN-PDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSV 242 S + HT V+ ++++ +L S D T+ +++ T+ S AH V Sbjct: 229 SVYHRHTAVVNDLQFHLQHEALLTSVSDDCTLQIHD----TRLPSSSSASQCVKAHEQPV 284 Query: 243 FGLTWSP-DGTKIASASADKTIKIWNVATL 271 G+ ++P + +A+ASAD T+ +W++ L Sbjct: 285 NGVAFNPFNDYLLATASADHTVALWDLRRL 314 Score = 29.3 bits (64), Expect = 5.6, Method: Compositional matrix adjust. Identities = 33/160 (20%), Positives = 71/160 (44%), Gaps = 15/160 (9%) Query: 463 VAVGGQDSKVHVYKLSGASVSEVKTI---------VHPAEITSVAFS-NNGAFLVATDQS 512 +A G +D+ + V+ + G S+S K+I H A + + F + A L + Sbjct: 198 LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTSVSDD 257 Query: 513 RKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVWNMNKPSDH 571 + + + + H V V+++P ++ LAT S D++V +W++ + + Sbjct: 258 CTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQR 317 Query: 572 PIIIKGAHAMSSVNSVIW--LNETTIVSAGQDSNIKFWNV 609 ++G V +V W +E +V++ D + W++ Sbjct: 318 LHTLEGHE--DEVYNVQWSPHDEPILVTSSTDRRVCVWDL 355 >5A9Q-7 nrPDB Length = 360 Score = 37.4 bits (85), Expect = 0.017, Method: Compositional matrix adjust. Identities = 25/89 (28%), Positives = 47/89 (52%), Gaps = 6/89 (6%) Query: 180 FKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHS 239 F +S +H +H V ++ G A+ D ++ ++ D +++G + + HS Sbjct: 2 FVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVW---DKSESGDWHCTASWKT-HS 57 Query: 240 GSVFGLTWS-PD-GTKIASASADKTIKIW 266 GSV+ +TW+ P+ G +AS S D+T +W Sbjct: 58 GSVWRVTWAHPEFGQVLASCSFDRTAAVW 86 Score = 31.6 bits (70), Expect = 0.97, Method: Compositional matrix adjust. Identities = 21/60 (35%), Positives = 32/60 (53%), Gaps = 7/60 (11%) Query: 177 GPPFKFK----STFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLY--NGVDGTK-TGVFE 229 G P KF+ + F H V V +N G++ AS+G DG + L+ N +D K TG+ + Sbjct: 261 GGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILK 320 >6CHG-A nrPDB Length = 312 Score = 37.4 bits (85), Expect = 0.018, Method: Compositional matrix adjust. Identities = 43/212 (20%), Positives = 86/212 (40%), Gaps = 22/212 (10%) Query: 162 RIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVD 221 +I+ + + ++E K H + ++ + ++PD AS D T+ + + + Sbjct: 26 ELIAICQNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSKCIASGSEDFTVEITHIIY 85 Query: 222 GTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGT 281 G + + H+ V + ++ G + S+S D++IK W+V + KT+ + Sbjct: 86 GRIRRL--------MGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTALKTMSAHS 137 Query: 282 RIEDQQLGIIWTK---QALVSISANGFINFVNPELG-SIDQVRYGHN-------KAITAL 330 D + I K L S S +G I + E G + + Y + I+ + Sbjct: 138 ---DAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTV 194 Query: 331 SSSADGKTLFSADAEGHINSWDISTGISNRVF 362 S +GK L + + W+ + G R F Sbjct: 195 KFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTF 226 Score = 37.0 bits (84), Expect = 0.027, Method: Compositional matrix adjust. Identities = 34/119 (28%), Positives = 60/119 (50%), Gaps = 15/119 (12%) Query: 495 TSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATG 554 TS S +G L+A Q+ ++ Y ++++ + T T H + C+ WSPD+ +A+G Sbjct: 17 TSCQISPDGE-LIAICQNTDMLVYEISSSKMMKLT---TTHKECINCLCWSPDSKCIASG 72 Query: 555 SLDNSVIVWNMNKPSDHPIIIKGAHAM---SSVNSVIWLNETTIV-SAGQDSNIKFWNV 609 S D +V + H I + M + V S+ + N+ I+ S+ D +IK W+V Sbjct: 73 SEDFTVEI-------THIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHV 124 Score = 33.1 bits (74), Expect = 0.41, Method: Compositional matrix adjust. Identities = 45/215 (20%), Positives = 80/215 (37%), Gaps = 23/215 (10%) Query: 27 TPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIW 86 +P G+ I C T + + S ++ T H SP ASG V I Sbjct: 22 SPDGELIAICQNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSKCIASGSEDFTVEI- 80 Query: 87 DTTQTTHILKTTIPVFSG---PVKDISWDSESKRIA--AVGEGRERFGHVFLFDTGTSNG 141 THI+ I G PV I ++++ + ++ E + + HV +GT+ Sbjct: 81 -----THIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEW-HVL---SGTALK 131 Query: 142 NLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKF--------V 193 ++ + A+ S+D + SGS D + IF+ T + + Sbjct: 132 TMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPI 191 Query: 194 HSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVF 228 +V+++ +G D + L+ GT F Sbjct: 192 STVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTF 226 Score = 32.7 bits (73), Expect = 0.47, Method: Compositional matrix adjust. Identities = 25/91 (27%), Positives = 38/91 (41%), Gaps = 16/91 (17%) Query: 191 KFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV----AHSGSVFGLT 246 K S + +PDG L A T V+E S K + H + L Sbjct: 14 KISTSCQISPDGELIAI------------CQNTDMLVYEISSSKMMKLTTTHKECINCLC 61 Query: 247 WSPDGTKIASASADKTIKIWNVATLKVEKTI 277 WSPD IAS S D T++I ++ ++ + + Sbjct: 62 WSPDSKCIASGSEDFTVEITHIIYGRIRRLM 92 Score = 29.6 bits (65), Expect = 3.5, Method: Compositional matrix adjust. Identities = 20/106 (18%), Positives = 47/106 (44%), Gaps = 6/106 (5%) Query: 419 VSADGDIAVAACYKHIAIY--SHGKLTEVPISYNSS--CVALSNDKQFVAVGGQDSKVHV 474 +S DG++ + +Y S K+ ++ ++ C+ S D + +A G +D V + Sbjct: 21 ISPDGELIAICQNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSKCIASGSEDFTVEI 80 Query: 475 YKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSV 520 + + + + H A + S+ ++N G L ++ + + V Sbjct: 81 THIIYGRIR--RLMGHTAPVISICYNNKGNILCSSSMDESIKEWHV 124 >4L9O-A nrPDB Length = 349 Score = 37.4 bits (85), Expect = 0.019, Method: Compositional matrix adjust. Identities = 34/135 (25%), Positives = 58/135 (42%), Gaps = 13/135 (9%) Query: 143 LTGQARAMNSVDFKP-SRP---FRIISGSDDNTVAIFE----GPPFKFKSTFGEHTKFVH 194 + G A +N+ + P S P R +SG DN V I+ F + F H+ +V Sbjct: 201 IQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVR 260 Query: 195 SVRYNPD---GSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG 251 V ++P S A+ D T++++ DG K+ +E L + +WS G Sbjct: 261 DVAWSPSRLSKSYIATASQDRTVLIWTK-DG-KSNKWEKQPLTKEKFPDVCWRASWSLSG 318 Query: 252 TKIASASADKTIKIW 266 +A + D + +W Sbjct: 319 NVLAISGGDNKVTLW 333 Score = 33.9 bits (76), Expect = 0.21, Method: Compositional matrix adjust. Identities = 49/203 (24%), Positives = 84/203 (41%), Gaps = 28/203 (13%) Query: 83 VRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLF--DTGTSN 140 ++I++ L T+ GPV ++W + + G V ++ D G N Sbjct: 93 IKIFEIDGENQRLVETLIGHEGPVWQVAW--AHPKFGVILASCSYDGKVLIWKEDNGVWN 150 Query: 141 --GNLTGQARAMNSVDFKPSR--PFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSV 196 + ++NSV + P P ++ S D ++I E FK H++ Sbjct: 151 KVAEHSVHQASVNSVSWAPHEYGPV-LLCASSDGKISIVE---FKDGGALEPIVIQGHAI 206 Query: 197 RYN---------PDGSL-FASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLT 246 N PD + F S G D + ++ D KT + E+++ + HS V + Sbjct: 207 GVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFI-EEEAFQ--GHSDWVRDVA 263 Query: 247 WSPD---GTKIASASADKTIKIW 266 WSP + IA+AS D+T+ IW Sbjct: 264 WSPSRLSKSYIATASQDRTVLIW 286 Score = 29.6 bits (65), Expect = 3.9, Method: Compositional matrix adjust. Identities = 73/335 (21%), Positives = 115/335 (34%), Gaps = 98/335 (29%) Query: 251 GTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVN 310 G ++A+ S+DKTIKI+ + E+Q+L + + Sbjct: 81 GRRLATCSSDKTIKIFEIDG-------------ENQRL-----------------VETLI 110 Query: 311 PELGSIDQVRYGHNK-AITALSSSADGKTLFSADAEGHINSWDISTGISNRVFP-DVHAT 368 G + QV + H K + S S DGK L W G+ N+V VH Sbjct: 111 GHEGPVWQVAWAHPKFGVILASCSYDGKVLI----------WKEDNGVWNKVAEHSVHQA 160 Query: 369 MITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAV- 427 + +VSW H P+ L S+DG I++ Sbjct: 161 SVN-----------SVSWAPH---------------------EYGPVLLCASSDGKISIV 188 Query: 428 ----AACYKHIAIYSHG----KLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSG 479 + I I H + PIS N ++FV+ GG D+ V +++ Sbjct: 189 EFKDGGALEPIVIQGHAIGVNAASWAPISLPD------NTRRFVS-GGCDNLVKIWRYDD 241 Query: 480 AS---VSEVKTIVHPAEITSVAFSNN---GAFLVATDQSRKVIPYSVANNFELAHTNSWT 533 A+ + E H + VA+S + +++ Q R V+ ++ T Sbjct: 242 AAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLT 301 Query: 534 FHTAKVAC--VSWSPDNVRLATGSLDNSVIVWNMN 566 C SWS LA DN V +W N Sbjct: 302 KEKFPDVCWRASWSLSGNVLAISGGDNKVTLWKEN 336 >3JRP-A nrPDB Length = 379 Score = 37.0 bits (84), Expect = 0.024, Method: Compositional matrix adjust. Identities = 29/118 (24%), Positives = 52/118 (44%), Gaps = 11/118 (9%) Query: 156 KPSRPFRIISGSDDNTVAIF----EGPPFKFKSTFGEHTKFVHSVRYNPD---GSLFAST 208 K SR F ++G DN V I+ + + +ST H+ +V V ++P S AS Sbjct: 170 KESRKF--VTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASV 227 Query: 209 GGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIW 266 D T +++ + G ++ LK ++ +WS G +A + D + +W Sbjct: 228 SQDRTCIIW--TQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 283 Score = 29.6 bits (65), Expect = 3.5, Method: Compositional matrix adjust. Identities = 51/213 (23%), Positives = 84/213 (39%), Gaps = 40/213 (18%) Query: 83 VRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGN 142 ++I++ TH L T+ GPV + W + + G V ++ NG Sbjct: 35 IKIFEVEGETHKLIDTLTGHEGPVWRVDW--AHPKFGTILASCSYDGKVLIWK--EENGR 90 Query: 143 LTG------QARAMNSVDFKPSR--PFRIISGSDDNTVAIFEGPPFKFKST-----FGEH 189 + + ++NSV + P P +++ S D V++ E FK T H Sbjct: 91 WSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS-DGKVSVVE---FKENGTTSPIIIDAH 146 Query: 190 TKFVHSVRYNP-----DGS--------LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV 236 V+S + P DG F + G D + ++ +T V E +L+ Sbjct: 147 AIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLE-STLE-- 203 Query: 237 AHSGSVFGLTWSPD---GTKIASASADKTIKIW 266 HS V + WSP + +AS S D+T IW Sbjct: 204 GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 236 >3JB9-S nrPDB Length = 488 Score = 37.0 bits (84), Expect = 0.024, Method: Compositional matrix adjust. Identities = 48/211 (22%), Positives = 88/211 (41%), Gaps = 26/211 (12%) Query: 97 TTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFK 156 +T+ +F G W + SK A + +F F +S G+ + +D K Sbjct: 242 STLKIFEGSALACCWLTSSKIAVATADA----ISIFEFPVSSSGLQSVGEPTSSIPIDEK 297 Query: 157 -------PSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTG 209 PS + +++ S++ IF + T +H + S+ +PDG+LF + Sbjct: 298 VNFLQAHPSGEY-LLAASNEKCY-IFSLKSQVYNITVAQH---ITSLAVHPDGNLFVAGL 352 Query: 210 GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGT-KIASASADKTIKIWNV 268 +G + + G + F HS V L + +G + + + D I IW++ Sbjct: 353 ENGELRFFETSSGNELTKFG-------PHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDL 405 Query: 269 ATLKVEKTIPVGTRIEDQQLGIIWTKQALVS 299 ++ + IP+ T++ L I T Q LVS Sbjct: 406 RKSELVQKIPLQTKVAAVSLDI--TSQLLVS 434 >3JRO-A nrPDB Length = 753 Score = 36.6 bits (83), Expect = 0.035, Method: Compositional matrix adjust. Identities = 29/118 (24%), Positives = 52/118 (44%), Gaps = 11/118 (9%) Query: 156 KPSRPFRIISGSDDNTVAIF----EGPPFKFKSTFGEHTKFVHSVRYNPD---GSLFAST 208 K SR F ++G DN V I+ + + +ST H+ +V V ++P S AS Sbjct: 168 KESRKF--VTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASV 225 Query: 209 GGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIW 266 D T +++ + G ++ LK ++ +WS G +A + D + +W Sbjct: 226 SQDRTCIIW--TQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 >5WLC-LN nrPDB Length = 776 Score = 36.6 bits (83), Expect = 0.037, Method: Compositional matrix adjust. Identities = 62/307 (20%), Positives = 112/307 (36%), Gaps = 71/307 (23%) Query: 59 SHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRI 118 SH++ + K +PS A G +GN+ IW+ +W E Sbjct: 52 SHKSNINKLTPSDLRLAIGRSNGNIEIWNPRN-------------------NWFQE---- 88 Query: 119 AAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP 178 + G++R G N+ G++ R F I + + G Sbjct: 89 MVIEGGKDRSIE------GLCWSNVNGESL----------RLFSIGGSTVVTEWDLATGL 132 Query: 179 PFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAH 238 P + + ++ + S+ N + +GT+VL + G GV E D++ + Sbjct: 133 PLR---NYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGG--PGVLEHDTIL-MRQ 186 Query: 239 SGSVFGLTWSPDGTKIASASADKTIKIWN-----------VATLKVEKTIPVGTRIEDQQ 287 V L W D I S D I+IW+ + T+KV+K T Sbjct: 187 EARVLTLAWKKDDFVIGGCS-DGRIRIWSAQKNDENMGRLLHTMKVDKAKKEST------ 239 Query: 288 LGIIWT------KQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFS 341 ++W+ + S + G I F + + +++Q H+ + L++ D +FS Sbjct: 240 --LVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFS 297 Query: 342 ADAEGHI 348 A + I Sbjct: 298 AGVDRKI 304 Score = 35.8 bits (81), Expect = 0.049, Method: Compositional matrix adjust. Identities = 40/151 (26%), Positives = 68/151 (45%), Gaps = 10/151 (6%) Query: 302 ANGFINFVNPELGSIDQ--VRYGHNKAITALS-SSADGKTL--FSADAEGHINSWDISTG 356 +NG I NP + + G +++I L S+ +G++L FS + WD++TG Sbjct: 72 SNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCWSNVNGESLRLFSIGGSTVVTEWDLATG 131 Query: 357 ISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVV--PAGGSGVDSSKAVANKLSSQP 414 + R + D ++ +I I D +V D+ V+ +GG GV + + ++ Sbjct: 132 LPLRNY-DCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARV 190 Query: 415 LGLAVSADGDIAVAACYK-HIAIYSHGKLTE 444 L LA D D + C I I+S K E Sbjct: 191 LTLAWKKD-DFVIGGCSDGRIRIWSAQKNDE 220 >6CHG-D nrPDB Length = 439 Score = 36.2 bits (82), Expect = 0.044, Method: Compositional matrix adjust. Identities = 23/82 (28%), Positives = 38/82 (46%), Gaps = 19/82 (23%) Query: 195 SVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA--------HSGSVFGLT 246 V+++P G A +G I++Y+ DSLK +A H+ SV + Sbjct: 32 CVKFSPRGDYLAVGCSNGAIIIYDM-----------DSLKPIAMLGTHSGAHTRSVQSVC 80 Query: 247 WSPDGTKIASASADKTIKIWNV 268 WS DG + S+ D K+W++ Sbjct: 81 WSNDGRYLWSSGRDWYAKLWDM 102 Score = 29.3 bits (64), Expect = 5.6, Method: Compositional matrix adjust. Identities = 22/84 (26%), Positives = 36/84 (42%), Gaps = 1/84 (1%) Query: 487 TIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWT-FHTAKVACVSWS 545 T+ P V FS G +L + +I Y + + +A + + HT V V WS Sbjct: 23 TLEVPVAAVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWS 82 Query: 546 PDNVRLATGSLDNSVIVWNMNKPS 569 D L + D +W+M +P+ Sbjct: 83 NDGRYLWSSGRDWYAKLWDMTQPT 106 >5LTD-A nrPDB Length = 525 Score = 35.8 bits (81), Expect = 0.057, Method: Compositional matrix adjust. Identities = 25/107 (23%), Positives = 49/107 (45%), Gaps = 6/107 (5%) Query: 172 VAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIV-LYNGVDGTKTGVFED 230 V IF+ + S H + ++ + DG L A+ GTI+ +++ G K F Sbjct: 204 VIIFDAKTLQPTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRR 263 Query: 231 DSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTI 277 + + ++ L +SPD + ++SA +T+ I+ + + TI Sbjct: 264 GT-----YPTKIYSLAFSPDNRFVIASSATETVHIFRLGEEEAANTI 305 >3ODT-A nrPDB Length = 313 Score = 35.4 bits (80), Expect = 0.072, Method: Compositional matrix adjust. Identities = 38/163 (23%), Positives = 68/163 (41%), Gaps = 11/163 (6%) Query: 253 KIASASADKTIKIWNVATLKVEKTIPVGTRIED---QQLGIIWTKQALVSISANGFINFV 309 K +ASADKTIK+W + +K I + I + + L ++ +S S +G I V Sbjct: 157 KFLTASADKTIKLW-----QNDKVIKTFSGIHNDVVRHLAVV-DDGHFISCSNDGLIKLV 210 Query: 310 NPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATM 369 + G + + GH + + +G + S + + W G +V + A Sbjct: 211 DMHTGDVLRTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIWSKENGSLKQVIT-LPAIS 268 Query: 370 ITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSS 412 I + S GD+ S D+ +++ S S + +L S Sbjct: 269 IWSVDCMSNGDIIVGSSDNLVRIFSQEKSRWASEDEIKGELRS 311 >5YZG-2 nrPDB Length = 646 Score = 35.0 bits (79), Expect = 0.086, Method: Compositional matrix adjust. Identities = 75/316 (23%), Positives = 121/316 (38%), Gaps = 58/316 (18%) Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVD-------------GTKTGVFEDDSLKN 235 HT + +R NP S+ G I + G T T ++E K Sbjct: 222 HTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFAKCK- 280 Query: 236 VAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTI-----------PVGTRIE 284 A+ SV +SPDG KIA+ +D+ ++I+ T K+ + + ++ Sbjct: 281 -AYPTSV---CFSPDGKKIATIGSDRKVRIFRFVTGKLMRVFDESLSMFTELQQMRQQLP 336 Query: 285 DQQLG-IIWTKQALVSISANGFINFVNPELGSIDQVRYG-----------HNKAITALSS 332 D + G + ++ L + A IN V E G V YG N+ + L Sbjct: 337 DMEFGRRMAVERELEKVDAVRLINIVFDETGHF--VLYGTMLGIKVINVETNRCVRILGK 394 Query: 333 SADGKT----LFSADAEGHINSWDISTGIS-NRVFPDVHATMITGIKTTSKGDLFTVSWD 387 + + LF A+ H + I S N V ++ A T + T+ K + F + Sbjct: 395 QENIRVMQLALFQGIAKKHRAATTIEMKASENPVLQNIQADP-TIVCTSFKKNRFYM--- 450 Query: 388 DHLKVVPAGGSGVDSSKAVAN-KLSSQPLGLAVSADGDIAVA-ACYKHIAIYS-HGKL-- 442 K P DS + V N K S + + A A+G V+ + H ++ H KL Sbjct: 451 -FTKREPEDTKSADSDRDVFNEKPSKEEVMAATQAEGPKRVSDSAIIHTSMGDIHTKLFP 509 Query: 443 TEVPISYNSSCVALSN 458 E P + + CV N Sbjct: 510 VECPKTVENFCVHSRN 525 >3BG0-A nrPDB Length = 316 Score = 35.0 bits (79), Expect = 0.095, Method: Compositional matrix adjust. Identities = 58/239 (24%), Positives = 94/239 (39%), Gaps = 33/239 (13%) Query: 56 TEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSES 115 T H A+ G A+ +V+I+D IL + GPV ++W Sbjct: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 Query: 116 KRIAAVGEGRERFGHVFLFDTGT--SNGNLTGQARAMNSVDFKPSRPFRIIS-GSDDNTV 172 +R ++ + GT + G ++NSV + P I++ GS D + Sbjct: 70 YGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 Query: 173 AIF----EGPPFKFKSTFGEHTKFVHSVRYNP---DGSL--------------FASTGGD 211 ++ EG ++ K HT ++V + P GSL FAS G D Sbjct: 130 SLLTYTGEG-QWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCD 188 Query: 212 GTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD----GTKIASASADKTIKIW 266 I L+ + G ++++ K AHS V + W+P + IAS S D + IW Sbjct: 189 NLIKLWK---EEEDGQWKEEQ-KLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 243 >5A9Q-2 nrPDB Length = 326 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 36/149 (24%), Positives = 61/149 (40%), Gaps = 27/149 (18%) Query: 176 EGPPFKFKSTFGEHTKFVHSVRYNPDGSL--------FASTGGDGTIVLYNG--VDGTKT 225 EG +K TF H V + ++P+ L F ++ D I L+ D + Sbjct: 59 EGIQYKTLRTF-HHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEY 117 Query: 226 GVFEDDSLKNVAHSGSVFGLTWSP-DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIE 284 V E H+ + GL + P +G +IAS S D T +IWN+ ++ + + Sbjct: 118 KVLE-------GHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFV-----LH 165 Query: 285 DQQLGIIWTKQA---LVSISANGFINFVN 310 + + W + L+ NG I F + Sbjct: 166 SPGMSVCWHPEETFKLMVAEKNGTIRFYD 194 >5MWJ-A nrPDB Length = 337 Score = 34.7 bits (78), Expect = 0.14, Method: Compositional matrix adjust. Identities = 35/128 (27%), Positives = 60/128 (46%), Gaps = 19/128 (14%) Query: 448 SYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLV 507 +Y SC L + + VGG+ S + ++ L+ A +K AE+TS A + + Sbjct: 98 NYIRSCKLLPDGCTLI-VGGEASTLSIWDLA-APTPRIK-----AELTSSA---PACYAL 147 Query: 508 ATDQSRKVIPYSVANNFELA----HTNS----WTFHTAKVACVSWSPDNVRLATGSLDNS 559 A KV +S ++ +A H + + HT +C+ S D +L TG LDN+ Sbjct: 148 AISPDSKVC-FSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNT 206 Query: 560 VIVWNMNK 567 V W++ + Sbjct: 207 VRSWDLRE 214 Score = 33.9 bits (76), Expect = 0.20, Method: Compositional matrix adjust. Identities = 36/154 (23%), Positives = 63/154 (40%), Gaps = 11/154 (7%) Query: 208 TGGDGTIVLYN-GVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIW 266 TGG G + +++ G K+ V + D L + S L PDG + T+ IW Sbjct: 68 TGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLL---PDGCTLIVGGEASTLSIW 124 Query: 267 NVAT----LKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYG 322 ++A +K E T + L I + S ++G I + ++ + G Sbjct: 125 DLAAPTPRIKAELT---SSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG 181 Query: 323 HNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 H + + S DG L++ + + SWD+ G Sbjct: 182 HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREG 215 Score = 29.3 bits (64), Expect = 4.6, Method: Compositional matrix adjust. Identities = 47/210 (22%), Positives = 72/210 (34%), Gaps = 33/210 (15%) Query: 68 SPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWD---------SESKRI 118 SP C S GN+ +WD T + + DIS D + R Sbjct: 150 SPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRS 209 Query: 119 AAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP 178 + EGR+ H F T Q + S+ + P+ + + N + Sbjct: 210 WDLREGRQLQQHDF-----------TSQ---IFSLGYCPTGEWLAVGMESSNVEVLHVNK 255 Query: 179 PFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAH 238 P K++ H V S+++ G F STG D + + G S+ Sbjct: 256 PDKYQLHL--HESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGA--------SIFQSKE 305 Query: 239 SGSVFGLTWSPDGTKIASASADKTIKIWNV 268 S SV S D I + S DK ++ V Sbjct: 306 SSSVLSCDISVDDKYIVTGSGDKKATVYEV 335 >2P9P-C nrPDB Length = 372 Score = 34.3 bits (77), Expect = 0.15, Method: Compositional matrix adjust. Identities = 36/159 (22%), Positives = 71/159 (44%), Gaps = 21/159 (13%) Query: 452 SCVALSNDKQFVAVGGQDSKVHVYKLSG---ASVSEVKTIVHPAEITSVAFSNNGAFLVA 508 SC A + D+ +A+ + +VH+Y+ SG V E+K H ++T V ++ + +V Sbjct: 12 SCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKE--HNGQVTGVDWAPDSNRIVT 69 Query: 509 TDQSRKVIPYSVANNFELAHTNSW--TFHTAKV----ACVSWSPDNVRLATGSLDNSVIV 562 R +++ +W T ++ CV W+P+ + A GS + + Sbjct: 70 CGTDRNAYVWTLKG-------RTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISI 122 Query: 563 WNMNKPSDHPII--IKGAHAMSSVNSVIWLNETTIVSAG 599 + +D + IK S+V S+ W + +++AG Sbjct: 123 CYFEQENDWWVCKHIKKP-IRSTVLSLDWHPNSVLLAAG 160 Score = 31.6 bits (70), Expect = 1.1, Method: Compositional matrix adjust. Identities = 14/55 (25%), Positives = 26/55 (47%), Gaps = 1/55 (1%) Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW 292 H+G V G+ W+PD +I + D+ +W + + T+ + RI + W Sbjct: 51 HNGQVTGVDWAPDSNRIVTCGTDRNAYVWTLKGRTWKPTLVI-LRINRAARCVRW 104 >5WYJ-BE nrPDB Length = 939 Score = 34.3 bits (77), Expect = 0.15, Method: Compositional matrix adjust. Identities = 47/197 (23%), Positives = 85/197 (43%), Gaps = 23/197 (11%) Query: 192 FVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG 251 FV SV + G+ +G+I +YN ++G+ K H +V G++ Sbjct: 462 FVKSVAMSQCGNFGFIGSSNGSITIYN----MQSGILRK---KYKLHKRAVTGISLDGMN 514 Query: 252 TKIASASADKTIKIW--NVATL--KVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFIN 307 K+ S D + + N +TL K++ P+ + + + AL +S I Sbjct: 515 RKMVSCGLDGIVGFYDFNKSTLLGKLKLDAPITAMVYHRSSDLFAL--ALDDLS----IV 568 Query: 308 FVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG--ISNRVFPDV 365 ++ + + +GH+ ITA S +G+ + SA + I +WD+ TG I + +V Sbjct: 569 VIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGIIVDNV 628 Query: 366 HATMITGIKTTSKGDLF 382 T +K + GDL Sbjct: 629 ----ATNVKFSPNGDLL 641 >5BJS-A nrPDB Length = 605 Score = 34.3 bits (77), Expect = 0.15, Method: Compositional matrix adjust. Identities = 24/70 (34%), Positives = 32/70 (45%), Gaps = 8/70 (11%) Query: 201 DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKI-ASASA 259 D L G +G + +YN +G V H G + L SP I ASAS Sbjct: 147 DQPLLCIAGNEGNVKVYNVTEGKLYRTL-------VGHGGGINDLATSPANPYIIASASD 199 Query: 260 DKTIKIWNVA 269 D TI+IW++A Sbjct: 200 DTTIRIWSLA 209 Score = 30.0 bits (66), Expect = 2.9, Method: Compositional matrix adjust. Identities = 34/185 (18%), Positives = 77/185 (41%), Gaps = 27/185 (14%) Query: 408 NKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSN---DKQFVA 464 + ++ QPL +G++ V + GKL + + L+ + +A Sbjct: 143 DPITDQPLLCIAGNEGNVKVYNV-------TEGKLYRTLVGHGGGINDLATSPANPYIIA 195 Query: 465 VGGQDSKVHVYKLSGASVSEVKTIV-----HPAEITSVAFSNNGAFLVATDQSRKV---- 515 D+ + ++ L+ + + H ++ SVAF +NG ++++ + + Sbjct: 196 SASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWA 255 Query: 516 IPYSVANNFEL------AHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNK-P 568 +P + E+ H +S H V CV++ D + L+ ++++++W + Sbjct: 256 LPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFYGDLI-LSRACHEDTIVLWRIEGFS 314 Query: 569 SDHPI 573 SD PI Sbjct: 315 SDDPI 319 >5CXB-B nrPDB Length = 369 Score = 34.3 bits (77), Expect = 0.17, Method: Compositional matrix adjust. Identities = 27/102 (26%), Positives = 44/102 (43%), Gaps = 24/102 (23%) Query: 179 PFKFKSTFGEHTKFVHSVRYNPDG-SLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKN-- 235 P+K T HT+ + +VR++ G LFA DG++ +++G +D L+N Sbjct: 277 PYK---TMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFHGK-------VPNDQLENPT 326 Query: 236 -----------VAHSGSVFGLTWSPDGTKIASASADKTIKIW 266 V + V + W P SA AD T ++W Sbjct: 327 IVPVKMLKGHKVVNKLGVLDIDWHPREPWCVSAGADGTARLW 368 >4PSX-B nrPDB Length = 401 Score = 34.3 bits (77), Expect = 0.18, Method: Compositional matrix adjust. Identities = 24/85 (28%), Positives = 42/85 (49%), Gaps = 10/85 (11%) Query: 188 EHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGV-FEDDSLKNVAHSGSVFGL 245 EH + + RY P D ++ A+ G GT LY+ +G ++ + F D+ ++ S V G Sbjct: 116 EHEEEITRARYMPQDPNIVATINGQGTTFLYSRSEGLQSTLKFHKDNGYALSFSTLVKG- 174 Query: 246 TWSPDGTKIASASADKTIKIWNVAT 270 ++ S S D T+ +W V + Sbjct: 175 -------RLLSGSDDHTVALWEVGS 192 Score = 28.9 bits (63), Expect = 6.2, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 40/72 (55%), Gaps = 7/72 (9%) Query: 162 RIISGSDDNTVAIFE----GPPFKFKSTFGE-HTKFVHSVRY-NPDGSLFASTGGDGTIV 215 R++SGSDD+TVA++E G P K T+ + H+ ++ ++ N + LF + D +++ Sbjct: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSED-SLL 233 Query: 216 LYNGVDGTKTGV 227 N V T + Sbjct: 234 KINDVRANNTTI 245 >5OQL-L nrPDB Length = 557 Score = 33.1 bits (74), Expect = 0.34, Method: Compositional matrix adjust. Identities = 26/112 (23%), Positives = 47/112 (41%), Gaps = 8/112 (7%) Query: 502 NGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNV-RLATGSLDNSV 560 +G LVA + + ++ + V +W H V WSP + L + S D +V Sbjct: 110 DGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTV 169 Query: 561 IVWNMNKPSDHPIIIKGAHAMSSVNSVIWL----NETTIVSAGQDSNIKFWN 608 +W++ PS+ P + H V ++ N +VS D ++ W+ Sbjct: 170 RLWDL--PSNDPTRLFTGHT-DYVRCGAFMPGSANSNLLVSGSYDETVRVWD 218 Score = 31.6 bits (70), Expect = 0.98, Method: Compositional matrix adjust. Identities = 48/252 (19%), Positives = 100/252 (39%), Gaps = 50/252 (19%) Query: 125 RERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF---EGPPFK 181 RE + FD+ G + R + ++G D + +F +G Sbjct: 89 REPLKTIGRFDSEAHCGEIRPDGRVL-------------VAGEDTGRMQVFDVGQGTRAV 135 Query: 182 FKSTFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSG 240 T+ H + V +++P + + S D T+ L++ T +F + + G Sbjct: 136 ILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHT--DYVRCG 193 Query: 241 SVFGLTWSPDGTKIASASADKTIKIWN-------VATLK----VEKTIPVGTRIEDQQLG 289 + + S + + S S D+T+++W+ V T K +E +P+ + Sbjct: 194 AF--MPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIEDVLPLPS-------- 243 Query: 290 IIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHIN 349 L++ S N I+ ++ ++ H K +T+LS ++ G+ + S +GH+ Sbjct: 244 ----GTTLLAASGNA-ISVLDLVAAKPLRLITNHQKTVTSLSLASQGRRVVSGSLDGHVK 298 Query: 350 -----SWDISTG 356 SW++ G Sbjct: 299 VFETTSWNVVAG 310 >5WLC-LJ nrPDB Length = 513 Score = 32.7 bits (73), Expect = 0.46, Method: Compositional matrix adjust. Identities = 26/133 (19%), Positives = 56/133 (42%), Gaps = 10/133 (7%) Query: 139 SNGNLTGQARAMNSVDFKPSRP--FRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSV 196 ++ L + ++ + F P P F + S + V IF + TF V+S Sbjct: 31 TSAQLVKEHNSVTHISFNPQHPHDFAVTSST---RVQIFSSRTRQVIKTFSRFKDVVYSA 87 Query: 197 RYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIAS 256 + DG L + G + +Y+ + +T + ++ + H + D +A+ Sbjct: 88 SFRSDGKLLCAGDATGLVSVYDSYN-PRTILLSINASTHPTHVTKFH----TQDNKILAT 142 Query: 257 ASADKTIKIWNVA 269 AS D+ ++W+++ Sbjct: 143 ASDDRVTRLWDIS 155 >3W15-A nrPDB Length = 368 Score = 32.7 bits (73), Expect = 0.47, Method: Compositional matrix adjust. Identities = 33/144 (22%), Positives = 52/144 (36%), Gaps = 33/144 (22%) Query: 152 SVDFKPSRPFRIISGSDDNTVAIFE------------------------GPPFKFKSTFG 187 + DF RP+ + +G DN + I++ G + + Sbjct: 227 TCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSP 286 Query: 188 EHTKFVHSVRYNPDGSLFASTGGDGTIVLY--NGVDGTKTGVFEDDSLKNVAHSGSVFGL 245 H+ + S Y+ ++ DG Y N D TK +F HS VFG Sbjct: 287 HHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNF-----TQHSEFVFGA 341 Query: 246 TWSPDGTK--IASASADKTIKIWN 267 WS G +AS + D + +WN Sbjct: 342 DWSLWGKPGYVASTAWDGNLFVWN 365 >2I3T-A nrPDB Length = 341 Score = 32.7 bits (73), Expect = 0.53, Method: Compositional matrix adjust. Identities = 22/76 (28%), Positives = 38/76 (50%), Gaps = 4/76 (5%) Query: 193 VHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKT---GVFEDDSLKNVAHSGSVFGLTWSP 249 V+S+ ++P + G DG I +N K F +DS+ +A S ++ L S Sbjct: 254 VNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACSDNILCLATSD 313 Query: 250 DGTKIASASADKTIKI 265 D K +A+ D+TI++ Sbjct: 314 DTFK-TNAAIDQTIEL 328 >1XFD-A nrPDB Length = 723 Score = 32.3 bits (72), Expect = 0.59, Method: Compositional matrix adjust. Identities = 24/66 (36%), Positives = 38/66 (57%), Gaps = 14/66 (21%) Query: 207 STGGDGTIVLYNGVDGTKTGVFEDDSLK-NVAHSGSVFGLTWSPDGTKIASASA-DKTIK 264 STG +G V+YNG+ ++E++ LK ++AH WSPDGT++A A+ D + Sbjct: 151 STGKEG--VIYNGLSD---WLYEEEILKTHIAH-------WWSPDGTRLAYAAINDSRVP 198 Query: 265 IWNVAT 270 I + T Sbjct: 199 IMELPT 204 >4XFV-A nrPDB Length = 792 Score = 32.3 bits (72), Expect = 0.61, Method: Compositional matrix adjust. Identities = 32/136 (23%), Positives = 54/136 (39%), Gaps = 15/136 (11%) Query: 142 NLTGQARAMNSVDFKPSRPFRIISGSDDNTVA-----IFEGPPF-KFKSTFGEHTKFVHS 195 L G + +D P + I S N V IF + + K H+ + Sbjct: 557 KLYGHGFEITCLDISPDQKL-IASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITR 615 Query: 196 VRYNPDGSLFASTGGDGTIVLY--NGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD--G 251 ++++ DG S D L+ N D T F+++ H+ ++ W+P G Sbjct: 616 LKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEK----PHTRIIWDADWAPLEFG 671 Query: 252 TKIASASADKTIKIWN 267 +AS DKT+K+W Sbjct: 672 NVFVTASRDKTVKVWR 687 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 19/59 (32%), Positives = 29/59 (49%), Gaps = 4/59 (6%) Query: 209 GGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 G TI L++ ++ GV+ +LK H V + + PD + SAS D +KIW Sbjct: 37 GAGKTIALWDPIEPNNKGVYA--TLK--GHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 91 Score = 28.5 bits (62), Expect = 8.3, Method: Compositional matrix adjust. Identities = 17/82 (20%), Positives = 35/82 (42%), Gaps = 2/82 (2%) Query: 490 HPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNV 549 H AE+T V F + F+V+ + V + + L + ++ + +S P + Sbjct: 62 HEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLI 121 Query: 550 RLATGSLDNSVIVWNMNKPSDH 571 + G D ++ +W N +D Sbjct: 122 --SVGCADGTISIWRQNIQNDE 141 Score = 28.5 bits (62), Expect = 8.3, Method: Compositional matrix adjust. Identities = 18/60 (30%), Positives = 29/60 (48%), Gaps = 6/60 (10%) Query: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAH------AMSSVNSVI 588 H A+V CV + PD+ + + S D+ V +W S I H A+S++ S+I Sbjct: 62 HEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLI 121 >2PM9-A nrPDB Length = 416 Score = 32.3 bits (72), Expect = 0.62, Method: Compositional matrix adjust. Identities = 42/195 (21%), Positives = 84/195 (43%), Gaps = 37/195 (18%) Query: 422 DGDIAVAACYKHIAIYSHGKLTEVPISYN--SSCVALSNDKQFVAVGGQDSKVHVYKLSG 479 D +A I I+ K TE P +Y + ++S+ + +++ S HV+ +G Sbjct: 126 DNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAG 185 Query: 480 ASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKV 539 +S N A + ++VI L++T+ + ++ Sbjct: 186 SS--------------------NFASIWDLKAKKEVI--------HLSYTSPNSGIKQQL 217 Query: 540 ACVSWSPDN---VRLATGS-LDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWL--NET 593 + V W P N V ATGS D S+++W++ + ++ P+ + S+ W +E Sbjct: 218 SVVEWHPKNSTRVATATGSDNDPSILIWDL-RNANTPLQTLNQGHQKGILSLDWCHQDEH 276 Query: 594 TIVSAGQDSNIKFWN 608 ++S+G+D+ + WN Sbjct: 277 LLLSSGRDNTVLLWN 291 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 48/220 (21%), Positives = 89/220 (40%), Gaps = 34/220 (15%) Query: 75 ASGDVHGNVRIWDTTQTTHILKTTIPVFSG-------PVKDISWDSESKRIAAVGEGRER 127 ASG +G + IWD + T P+ G V ++W+ + A G Sbjct: 130 ASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASA-GSSN 188 Query: 128 FGHVFLFDTGTSNGNL------TGQARAMNSVDFKPSRPFRI--ISGSD-DNTVAIFE-- 176 F ++ +L +G + ++ V++ P R+ +GSD D ++ I++ Sbjct: 189 FASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLR 248 Query: 177 --GPPFKFKSTFGE-HTKFVHSVRY-NPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDS 232 P + T + H K + S+ + + D L S+G D T++L+N + F Sbjct: 249 NANTPLQ---TLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFP--- 302 Query: 233 LKNVAHSGSVFGLTWSPDGTKI-ASASADKTIKIWNVATL 271 A F ++P+ + A AS D I++ + L Sbjct: 303 ----ARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQNL 338 Score = 30.0 bits (66), Expect = 3.0, Method: Compositional matrix adjust. Identities = 22/60 (36%), Positives = 36/60 (60%), Gaps = 8/60 (13%) Query: 535 HTAKVACVSWS--PDNVRLATGSLDNSVIVWNMNK----PSDHPIIIKGAHAMSSVNSVI 588 H++ V V ++ DNV LA+G + + +W+MNK PS++ + G +MSSV+ VI Sbjct: 112 HSSSVKTVKFNAKQDNV-LASGGNNGEIFIWDMNKCTESPSNYTPLTPG-QSMSSVDEVI 169 >3DW8-B nrPDB Length = 447 Score = 32.3 bits (72), Expect = 0.68, Method: Compositional matrix adjust. Identities = 41/199 (20%), Positives = 79/199 (39%), Gaps = 46/199 (23%) Query: 193 VHSVRYNPDGSLFASTGGDGTIVLY-----NGVDGTKTGVF-----------EDDSLKNV 236 + +V +N G L A+ G +V++ N + G + E D LK++ Sbjct: 31 ISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSL 90 Query: 237 AHSGSVFGLTWSP--DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQ------- 287 + + W P + + ++ DKTIK+W ++ P G ++++ Sbjct: 91 EIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISE---RDKRPEGYNLKEEDGRYRDPT 147 Query: 288 ----LGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSAD 343 L + + + + A+ F N H I ++S ++D +T SAD Sbjct: 148 TVTTLRVPVFRPMDLMVEASPRRIFAN-----------AHTYHINSISINSDYETYLSAD 196 Query: 344 AEGHINSWDISTGISNRVF 362 + IN W + I++R F Sbjct: 197 -DLRINLWHLE--ITDRSF 212 >5BPT-A nrPDB Length = 741 Score = 32.0 bits (71), Expect = 0.78, Method: Compositional matrix adjust. Identities = 33/133 (24%), Positives = 60/133 (45%), Gaps = 22/133 (16%) Query: 491 PAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTF----HTAK-VACVSWS 545 P EI +A+S + +++ +V+ + +AN W+ +T K V C++W Sbjct: 13 PHEIIFLAWSPKRDLIALVNKAGEVLLHRLAN-----IQRVWSLPPNENTGKEVTCLAWR 67 Query: 546 PDNVRLATGSLD-NSVIVWNMNKPS-------DHPIIIKGAHAMSSVNSVIWLNETTIVS 597 PD LA G D VI+ ++ KP + PI ++ NSV+ T+ + Sbjct: 68 PDGKILAFGLADTKKVILCDVEKPESLHSFSLETPISCMQWMEVNVENSVL----TSFYN 123 Query: 598 AGQDSNIKFWNVP 610 A ++N+ +P Sbjct: 124 AEDEANVLLPKLP 136 >4CKE-A nrPDB Length = 844 Score = 31.6 bits (70), Expect = 1.1, Method: Compositional matrix adjust. Identities = 26/91 (28%), Positives = 39/91 (42%), Gaps = 16/91 (17%) Query: 131 VFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHT 190 V LF + N+ + + N++D + FR +S P FGE + Sbjct: 377 VILFYSKGPKSNIDFKIKKENTIDQTANVVFRYMSSE-----------PI----IFGESS 421 Query: 191 KFVHSVRYNPDGSLFASTGGDGTIVLYNGVD 221 FV +++ D F G G IVLYNGV+ Sbjct: 422 IFVEYKKFSNDKG-FPKEYGSGKIVLYNGVN 451 >6FAH-B nrPDB Length = 262 Score = 31.6 bits (70), Expect = 1.2, Method: Compositional matrix adjust. Identities = 37/142 (26%), Positives = 53/142 (37%), Gaps = 26/142 (18%) Query: 329 ALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDD 388 L+ AD L S A G ++W S AT+ GIK K DL Sbjct: 74 CLAMGADEAYLLSDRAFGGADTWATS------------ATLAAGIKKVKKVDL------- 114 Query: 389 HLKVVPAGGSGVDSSKAVANKLSSQPLGLAVS---ADGDIAVAACYKHIAIYSHGKLTEV 445 V AG +D A +Q L + V D I H + ++ EV Sbjct: 115 ----VLAGRQAIDGDTAQVGSQIAQRLKMPVVTYVEDIKIEDKKAIVHRQMEDGYEVIEV 170 Query: 446 PISYNSSCVALSNDKQFVAVGG 467 + +CV ND ++++VGG Sbjct: 171 QLPCLLTCVKELNDPRYMSVGG 192 >6ELZ-p nrPDB Length = 460 Score = 31.2 bits (69), Expect = 1.3, Method: Compositional matrix adjust. Identities = 73/358 (20%), Positives = 137/358 (38%), Gaps = 64/358 (17%) Query: 73 YCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERF---- 128 + SG G VR WD + ++ SGP++ + + S ++ ++A + R Sbjct: 117 HIISGSYDGIVRTWDLSGN---VQKQYSGHSGPIRAVKYISNTRLVSAGNDRTLRLWKTK 173 Query: 129 ----------------GHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTV 172 + G + L G + S+D S RI+S S DN++ Sbjct: 174 NDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDV--SDNSRILSASYDNSI 231 Query: 173 AIFEGPPFKFKSTFGEHTKFVHSVR--YNPDGSLFASTGGDGTIVLYNGVDGTKTGVFED 230 F ST + V + NP+ + + + + +G + + Sbjct: 232 G--------FWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGTIRRRAPLSLL 283 Query: 231 DSLKNVAHSGSVFGLTW-SPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQL- 288 +S H+ V + + S D T S S D TIK W++ T + + TR L Sbjct: 284 ES-----HTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARC-----IDTRTTSYSLL 333 Query: 289 --GIIWTKQALVSISANGFINFVNPELGS----IDQVRYGHNKAITALSSSADGK-TLFS 341 + T L S+ I +P +G+ Q GH +++L + + + L S Sbjct: 334 SIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCS 393 Query: 342 ADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKG---DLFTVSWDDHLKVVPAG 396 +G + WD+ + ++ ++ T+ K+ KG +F V W + + ++ AG Sbjct: 394 GSHDGTVKVWDVRS--TSPMY-----TITREDKSVQKGVNDKVFAVKWAEKVGIISAG 444 Score = 30.8 bits (68), Expect = 2.0, Method: Compositional matrix adjust. Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 6/78 (7%) Query: 535 HTAKVACVSWSPDNVR-LATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSS-----VNSVI 588 H V+ + P+N L +GS D +V VW++ S I + ++ V +V Sbjct: 374 HKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVK 433 Query: 589 WLNETTIVSAGQDSNIKF 606 W + I+SAGQD I+ Sbjct: 434 WAEKVGIISAGQDKKIQI 451 >5WLC-LS nrPDB Length = 594 Score = 31.2 bits (69), Expect = 1.4, Method: Compositional matrix adjust. Identities = 33/134 (24%), Positives = 57/134 (42%), Gaps = 25/134 (18%) Query: 451 SSCVALSNDK----QFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAE-----ITSVAFSN 501 ++C AL K +++AVG + V++Y + A S T V + I+++ FS Sbjct: 466 TTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSP 525 Query: 502 NGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHT---------AKVACVSWSPDNVRLA 552 +G L ++ V + L H S + + KV V++SP LA Sbjct: 526 DGQILCMASRA-------VKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLA 578 Query: 553 TGSLDNSVIVWNMN 566 G+ V +W +N Sbjct: 579 VGNEQGKVRLWKLN 592 >4E5Z-B nrPDB Length = 436 Score = 30.4 bits (67), Expect = 2.3, Method: Compositional matrix adjust. Identities = 17/63 (26%), Positives = 30/63 (47%), Gaps = 2/63 (3%) Query: 462 FVAVGGQDSKVHVYKLSG--ASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYS 519 F+A D V ++ L S + ++ H + + FS +GA L+ TDQ ++ YS Sbjct: 265 FLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYS 324 Query: 520 VAN 522 + Sbjct: 325 ASQ 327 >4D3F-A nrPDB Length = 310 Score = 30.4 bits (67), Expect = 2.6, Method: Compositional matrix adjust. Identities = 17/48 (35%), Positives = 25/48 (52%), Gaps = 1/48 (2%) Query: 559 SVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKF 606 SV VWN ++ KGA +S+VN + NE I+S D N+ + Sbjct: 46 SVTVWNRTSSKADQLVAKGAIRVSTVNEALAANELVILSL-TDYNVMY 92 >5TF2-A nrPDB Length = 407 Score = 30.0 bits (66), Expect = 2.7, Method: Compositional matrix adjust. Identities = 23/87 (26%), Positives = 37/87 (42%), Gaps = 5/87 (5%) Query: 522 NNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAM 581 N + T+ + KV C ++ DN LATG D V VW + PS ++ AH Sbjct: 160 ENLQAVQTDFSSDPLQKVVC--FNHDNTLLATGGTDGYVRVWKV--PSLEKVLEFKAHE- 214 Query: 582 SSVNSVIWLNETTIVSAGQDSNIKFWN 608 + + + +V+ G+D W Sbjct: 215 GEIEDLALGPDGKLVTVGRDLKASVWQ 241 >3DWL-C nrPDB Length = 377 Score = 29.6 bits (65), Expect = 4.1, Method: Compositional matrix adjust. Identities = 19/66 (28%), Positives = 31/66 (46%), Gaps = 1/66 (1%) Query: 498 AFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLD 557 AF++ V T + +V Y N H +++ H V CV W+P + R+ T S D Sbjct: 18 AFNSQRTEFVTTTATNQVELYEQDGN-GWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQD 76 Query: 558 NSVIVW 563 + V+ Sbjct: 77 RNAYVY 82 Score = 29.6 bits (65), Expect = 4.4, Method: Compositional matrix adjust. Identities = 23/98 (23%), Positives = 41/98 (41%), Gaps = 6/98 (6%) Query: 170 NTVAIFE--GPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGV 227 N V ++E G +K TF +H K V V + P + + D +Y + G Sbjct: 33 NQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDRNAYVY---EKRPDGT 89 Query: 228 FEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKI 265 ++ + + + F + WSP+ K A S + I + Sbjct: 90 WKQTLVLLRLNRAATF-VRWSPNEDKFAVGSGARVISV 126 Score = 29.3 bits (64), Expect = 5.7, Method: Compositional matrix adjust. Identities = 20/64 (31%), Positives = 32/64 (50%), Gaps = 1/64 (1%) Query: 539 VACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHP-IIIKGAHAMSSVNSVIWLNETTIVS 597 V V +SP LA D+SV + + P P +I + + S++W NE+ IV+ Sbjct: 208 VHAVGFSPSGNALAYAGHDSSVTIAYPSAPEQPPRALITVKLSQLPLRSLLWANESAIVA 267 Query: 598 AGQD 601 AG + Sbjct: 268 AGYN 271 >6IYY-A nrPDB Length = 317 Score = 28.9 bits (63), Expect = 6.3, Method: Compositional matrix adjust. Identities = 41/218 (18%), Positives = 83/218 (38%), Gaps = 27/218 (12%) Query: 74 CASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFL 133 C + + R+++T K G V + +A VG G+++ V + Sbjct: 21 CFACGMENGFRVYNTDPLKE--KEKQEFLEGGVGHVEMLFRCNYLALVGGGKKK---VMI 75 Query: 134 FDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFV 193 +D + ++ + S + + D V + + F T H V Sbjct: 76 WD----------DLKKKTVIEIEFSTEVKAVKLRRDRIVVVLDSMIKVFTFTHNPHQLHV 125 Query: 194 HSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV--------AHSGSVFGL 245 YNP G + +++ + GT TG + L + AH G + + Sbjct: 126 FETCYNPKGLCVLCPNSNNSLLAF---PGTHTGHVQLVDLASTEKPPVDIPAHEGVLSCI 182 Query: 246 TWSPDGTKIASASADKT-IKIWNVATLKVEKTIPVGTR 282 + GT+IA+AS T I+I++ ++ + + + G++ Sbjct: 183 ALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQ 220 >5FA5-B nrPDB Length = 367 Score = 28.9 bits (63), Expect = 7.2, Method: Compositional matrix adjust. Identities = 16/41 (39%), Positives = 26/41 (63%), Gaps = 3/41 (7%) Query: 530 NSWTFHTAKVACVSWSP--DNVRLATGSLDNSVIVWNMNKP 568 +S+ H A+V CV+ SP D+V L+ S DN +++W+ P Sbjct: 186 SSYRAHAAQVTCVAASPHKDSVFLSC-SEDNRILLWDTRCP 225 >5AMS-A nrPDB Length = 431 Score = 28.5 bits (62), Expect = 8.4, Method: Compositional matrix adjust. Identities = 36/157 (22%), Positives = 59/157 (37%), Gaps = 9/157 (5%) Query: 462 FVAVGGQDSKVHVYKLSGASVSEVKTIVHPAE-ITSVAFSNNGAFLVATDQSRKVIPYSV 520 V GG D+ H++ T+ E + S +F++ G FLV D S KV+ + Sbjct: 79 LVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMG 138 Query: 521 ANNFELAHTNSWTFHTAKVACVSWSPDNVR-LATGSLDNSVIVWNMNKP--SDHPIIIKG 577 S ++ + P R A G+ D SV + +N+ S ++ Sbjct: 139 QKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGF 198 Query: 578 AHAMSS-----VNSVIWLNETTIVSAGQDSNIKFWNV 609 H +N+ N +V+ DS I WN Sbjct: 199 VHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNC 235 >6ILS-A nrPDB Length = 313 Score = 28.5 bits (62), Expect = 8.5, Method: Compositional matrix adjust. Identities = 23/78 (29%), Positives = 32/78 (41%), Gaps = 3/78 (3%) Query: 187 GEHTKFVHSVRYNPDGSLFASTGGDG--TIVLYNGVDGTK-TGVFEDDSLKNVAHSGSVF 243 G H +V SV P G DG +I++ G + + DD L+ V ++G V Sbjct: 81 GVHLDYVRSVNNEPTGHAVVMLQSDGQNSIIIVGGANMKAWPEIMSDDDLEIVRNAGIVL 140 Query: 244 GLTWSPDGTKIASASADK 261 PD I A A K Sbjct: 141 LQREIPDSINIQVAKAVK 158 >1RY6-A nrPDB Length = 360 Score = 28.5 bits (62), Expect = 8.9, Method: Compositional matrix adjust. Identities = 21/92 (22%), Positives = 38/92 (41%), Gaps = 2/92 (2%) Query: 35 YCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHI 94 Y NG G + YT Q +P + A+GD+ + I+D T I Sbjct: 80 YENGCVCSCFAYGQTGSGKTYTMLGSQPYGQSDTPGIFQYAAGDIFTFLNIYDKDNTKGI 139 Query: 95 LKTTIPVFSGPVKDISWDSESKRIAAVGEGRE 126 + ++ G + D+ + K +AA+ G++ Sbjct: 140 FISFYEIYCGKLYDLLQ--KRKMVAALENGKK 169 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1NR0-A nrPDB 693 0.0 1PI6-A nrPDB 376 e-104 5M25-A nrPDB 257 9e-69 5FL8-q nrPDB 255 3e-68 2H9P-A nrPDB 246 2e-65 5MZH-A nrPDB 237 1e-62 1VYH-C nrPDB 234 8e-62 3DM0-A nrPDB 231 7e-61 5NNZ-B nrPDB 219 2e-57 6QX9-5O nrPDB 217 9e-57 3FM0-A nrPDB 217 2e-56 6MZM-G nrPDB 214 1e-55 6F3T-A nrPDB 212 5e-55 5WYK-BB nrPDB 209 3e-54 6Q8F-A nrPDB 207 1e-53 5GAN-H nrPDB 200 2e-51 5WLC-LO nrPDB 198 5e-51 6QX9-4B nrPDB 196 3e-50 5I2T-A nrPDB 194 1e-49 3MKQ-A nrPDB 193 2e-49 4V6W-Ag nrPDB 192 5e-49 5FVM-C nrPDB 191 9e-49 3JB9-g nrPDB 190 1e-48 5NZU-C nrPDB 190 2e-48 3JB9-L nrPDB 189 3e-48 6HQA-B nrPDB 188 4e-48 6G51-g nrPDB 188 6e-48 2YNP-A nrPDB 187 2e-47 5G04-R nrPDB 185 4e-47 4V7E-Bg nrPDB 184 1e-46 5OQL-J nrPDB 182 4e-46 4GGA-A nrPDB 182 4e-46 5WYJ-BC nrPDB 181 6e-46 5LCW-Q nrPDB 180 2e-45 4V8M-A7 nrPDB 180 2e-45 5OPT-p nrPDB 175 4e-44 6N9G-C nrPDB 175 4e-44 4N14-A nrPDB 174 1e-43 6HHQ-h nrPDB 173 2e-43 3C9C-A nrPDB 173 2e-43 6EOJ-D nrPDB 171 1e-42 5Y1U-A nrPDB 168 7e-42 5Y88-O nrPDB 167 1e-41 5Z56-q nrPDB 164 9e-41 5WLC-LU nrPDB 163 2e-40 3CFV-B nrPDB 163 3e-40 5XYI-g nrPDB 162 4e-40 5WBU-D nrPDB 161 5e-40 5K1B-B nrPDB 160 1e-39 6J6H-n nrPDB 160 2e-39 6ID0-T nrPDB 158 6e-39 4LG8-A nrPDB 158 6e-39 3JAP-g nrPDB 158 8e-39 4BTS-AR nrPDB 156 2e-38 4BH6-A nrPDB 156 4e-38 5L9T-R nrPDB 155 8e-38 6GMH-W nrPDB 154 9e-38 5A31-R nrPDB 153 2e-37 4AEZ-A nrPDB 151 6e-37 5WJC-A nrPDB 142 5e-34 6BX3-A nrPDB 141 9e-34 5OQL-d nrPDB 137 1e-32 2HES-X nrPDB 136 2e-32 4YCZ-A nrPDB 133 2e-31 5OV3-A nrPDB 125 5e-29 2AQ5-A nrPDB 123 2e-28 4J0W-A nrPDB 123 3e-28 3ACP-A nrPDB 123 3e-28 4A11-B nrPDB 120 2e-27 4J0X-A nrPDB 112 5e-25 5K19-A nrPDB 105 6e-23 6EM1-m nrPDB 101 1e-21 6C0F-s nrPDB 100 2e-21 6CB1-s nrPDB 100 2e-21 5OQL-X nrPDB 96 5e-20 6BX3-B nrPDB 94 2e-19 5MC6-j nrPDB 82 5e-16 4AV8-A nrPDB 68 9e-12 Sequences not found previously or not previously below threshold: 6EMK-B nrPDB 182 3e-46 5UZ7-B nrPDB 176 3e-44 6QDV-o nrPDB 176 3e-44 5YZG-W nrPDB 175 4e-44 4XFV-A nrPDB 148 5e-36 3JRO-A nrPDB 132 5e-31 4XYI-A nrPDB 131 7e-31 6CHG-A nrPDB 126 3e-29 3ODT-A nrPDB 124 9e-29 3JRP-A nrPDB 123 2e-28 4BZK-B nrPDB 119 2e-27 6ELZ-p nrPDB 116 3e-26 5OQL-L nrPDB 115 6e-26 4L9O-A nrPDB 115 7e-26 5WLC-SG nrPDB 112 4e-25 5MWJ-A nrPDB 110 2e-24 5WYJ-BE nrPDB 108 5e-24 4U1E-I nrPDB 106 3e-23 5K0Y-T nrPDB 105 7e-23 3BG0-A nrPDB 104 8e-23 5WLC-LN nrPDB 102 6e-22 5N4A-A nrPDB 100 1e-21 3W15-A nrPDB 98 1e-20 5WLC-LJ nrPDB 97 2e-20 5YZG-2 nrPDB 96 5e-20 5CXC-A nrPDB 95 9e-20 5BJS-A nrPDB 94 2e-19 3F3P-A nrPDB 93 2e-19 4PSX-B nrPDB 93 3e-19 5FA5-B nrPDB 92 8e-19 6E29-D nrPDB 91 1e-18 2PM9-A nrPDB 90 2e-18 4OWR-A nrPDB 90 3e-18 5CXB-B nrPDB 89 6e-18 6F1U-h nrPDB 86 3e-17 2P9P-C nrPDB 86 4e-17 3JZG-A nrPDB 85 7e-17 4E5Z-B nrPDB 85 8e-17 4G56-B nrPDB 84 2e-16 5M89-A nrPDB 83 5e-16 6CHG-D nrPDB 81 1e-15 5WLC-LS nrPDB 80 4e-15 5A9Q-7 nrPDB 76 5e-14 3EI3-B nrPDB 76 6e-14 5A9Q-2 nrPDB 73 3e-13 3I2N-A nrPDB 73 4e-13 5AMS-A nrPDB 73 4e-13 5LTD-A nrPDB 70 4e-12 3JB9-S nrPDB 70 4e-12 3DWL-C nrPDB 69 7e-12 5A9Q-0 nrPDB 68 1e-11 6IYY-A nrPDB 68 1e-11 5TF2-A nrPDB 66 3e-11 5WLC-LH nrPDB 63 5e-10 5WLC-LW nrPDB 60 4e-09 2I3T-A nrPDB 59 5e-09 3DW8-B nrPDB 59 5e-09 4NOX-A nrPDB 58 1e-08 6FYY-p nrPDB 57 2e-08 2VDU-B nrPDB 56 3e-08 6N8P-A nrPDB 56 5e-08 5AJA-A nrPDB 56 6e-08 5WLC-LL nrPDB 54 1e-07 6CVZ-A nrPDB 51 2e-06 4U1F-A nrPDB 50 3e-06 3WJ9-A nrPDB 50 3e-06 5K1H-B nrPDB 48 1e-05 5GRS-A nrPDB 45 1e-04 4YHC-A nrPDB 45 1e-04 5BPT-A nrPDB 43 3e-04 4FHN-A nrPDB 43 3e-04 5WLC-LV nrPDB 41 0.001 5CWW-B nrPDB 41 0.001 5TXC-A nrPDB 41 0.002 3MUN-A nrPDB 40 0.002 5BPW-A nrPDB 39 0.005 4IMM-A nrPDB 38 0.010 6IGB-A nrPDB 38 0.018 5OLJ-A nrPDB 36 0.040 6IGR-A nrPDB 36 0.045 1C5K-A nrPDB 34 0.21 4MHC-A nrPDB 34 0.22 3AZQ-A nrPDB 34 0.23 5WLC-LK nrPDB 33 0.48 3R3L-A nrPDB 31 1.4 5SUM-A nrPDB 31 1.5 2ZZK-A nrPDB 31 1.6 4R40-A nrPDB 30 2.6 3V8H-A nrPDB 30 3.1 1Z68-A nrPDB 29 4.3 2Z8G-A nrPDB 29 7.3 4H0U-A nrPDB 29 8.8 >1NR0-A nrPDB Length = 611 Score = 693 bits (1789), Expect = 0.0, Method: Composition-based stats. Identities = 611/611 (100%), Positives = 611/611 (100%) Query: 1 MSEFSQTALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSH 60 MSEFSQTALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSH Sbjct: 1 MSEFSQTALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSH 60 Query: 61 QTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAA 120 QTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAA Sbjct: 61 QTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAA 120 Query: 121 VGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPF 180 VGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPF Sbjct: 121 VGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPF 180 Query: 181 KFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSG 240 KFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSG Sbjct: 181 KFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSG 240 Query: 241 SVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSI 300 SVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSI Sbjct: 241 SVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSI 300 Query: 301 SANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNR 360 SANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNR Sbjct: 301 SANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNR 360 Query: 361 VFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVS 420 VFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVS Sbjct: 361 VFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVS 420 Query: 421 ADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGA 480 ADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGA Sbjct: 421 ADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGA 480 Query: 481 SVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVA 540 SVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVA Sbjct: 481 SVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVA 540 Query: 541 CVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQ 600 CVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQ Sbjct: 541 CVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQ 600 Query: 601 DSNIKFWNVPF 611 DSNIKFWNVPF Sbjct: 601 DSNIKFWNVPF 611 >1PI6-A nrPDB Length = 615 Score = 376 bits (966), Expect = e-104, Method: Composition-based stats. Identities = 191/643 (29%), Positives = 302/643 (46%), Gaps = 65/643 (10%) Query: 1 MSEFSQTALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTE------- 53 MS S + P P T R L P + I Y G S + V L D + Sbjct: 1 MSSISLKEIIPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAF---VRCLDDGDSKVPPVV 57 Query: 54 IYTEH-SHQTTVAKTSP--SGYYCASGDVHGNVRIW------DTTQTTHILKTTIPVFSG 104 +T H S T K SP Y SGD G V +W ++ +K+ V +G Sbjct: 58 QFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAG 117 Query: 105 PVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRII 164 P+ DISWD E +R+ VGEGR+ FG +D+G S G ++G ++ +N+ K SRP R + Sbjct: 118 PISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSM 177 Query: 165 SGSDDNTVAIFEGPPFKFKSTFGEHTK---FVHSVRYNPD-GSLFASTGGDGTIVLYNGV 220 + DD +V ++GPPFKF ++ H K FV V ++PD G + G D I ++G Sbjct: 178 TVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGK 237 Query: 221 DGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKV-EKTIPV 279 G EDD G +F L+W D K A+ AD TI++W+V T K +K Sbjct: 238 SGEFLKYIEDDQEPV---QGGIFALSW-LDSQKFATVGADATIRVWDVTTSKCVQKWTLD 293 Query: 280 GTRIEDQQLGIIWTKQA-LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKT 338 ++ +QQ+G++ T ++S+S +G +NF + + GHNK ITAL+ + Sbjct: 294 KQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP---- 349 Query: 339 LFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGS 398 L S +G I W S+ H+ +I + + + ++SWDD LKV Sbjct: 350 LISGSYDGRIMEWSSSSMH------QDHSNLIVSLDNSKAQEYSSISWDDTLKVNGI--- 400 Query: 399 GVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAI-YSHGKLTEVPISYNSSCVALS 457 ++ SQP + + DG AV + I S + NS A+S Sbjct: 401 -------TKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVS 453 Query: 458 NDKQFVAVGGQD-SKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVI 516 + +VAVG ++ + + V+KLS VS A+ + ++ S + ++ A D K++ Sbjct: 454 LSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKIL 513 Query: 517 PYSVANNFELAHTNSWTFHTAKVACVSWSP----------DNVRLATGSLDNSVIVWNMN 566 Y + + T+ W F T+K+ +SW P + +ATGSLD ++ ++++ Sbjct: 514 LYDLQSR--EVKTSRWAFRTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVK 571 Query: 567 KPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 +P II VN+++W +T+VS+G D+ IK WNV Sbjct: 572 RPM--KIIKALNAHKDGVNNLLWETPSTLVSSGADACIKRWNV 612 >5M25-A nrPDB Length = 434 Score = 257 bits (656), Expect = 9e-69, Method: Composition-based stats. Identities = 70/302 (23%), Positives = 126/302 (41%), Gaps = 17/302 (5%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSE 114 H+ + K SP+G + AS ++IW + TI + D++W S+ Sbjct: 141 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--FEKTISGHKLGISDVAWSSD 198 Query: 115 SKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAI 174 S + + + + ++ +G L G + + +F P + I+SGS D +V I Sbjct: 199 SNLLVSASDDK--TLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRI 255 Query: 175 FEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLK 234 ++ K T H+ V +V +N DGSL S+ DG +++ G DD Sbjct: 256 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 315 Query: 235 NVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWT- 293 V + +SP+G I +A+ D T+K+W+ + K KT G + E + ++ Sbjct: 316 ------PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY-TGHKNEKYCIFANFSV 368 Query: 294 --KQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSAD--AEGHIN 349 + +VS S + + N + I Q GH + + + + SA + I Sbjct: 369 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIK 428 Query: 350 SW 351 W Sbjct: 429 LW 430 Score = 236 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 81/400 (20%), Positives = 148/400 (37%), Gaps = 50/400 (12%) Query: 123 EGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKF 182 +G+E FL+D + T + M D + +I GS + P + Sbjct: 79 QGKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHREQI-GGSATQSKPTPVKPNYAL 137 Query: 183 KSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSV 242 K T HTK V SV+++P+G AS+ D I ++ DG H + Sbjct: 138 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-------GHKLGI 190 Query: 243 FGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISA 302 + WS D + SAS DKT+KIW+V++ K KT+ G +VS S Sbjct: 191 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK-GHSNYVFCCNFNPQSNLIVSGSF 249 Query: 303 NGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVF 362 + + + + G + H+ ++A+ + DG + S+ +G WD ++G + Sbjct: 250 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 309 Query: 363 PDVHATMITGIKTTSKGDL-FTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSA 421 D ++ +K + G + D+ LK+ Sbjct: 310 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLW---------------------------- 341 Query: 422 DGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGAS 481 D + C K Y+ K + I N S +++ G +D+ V+++ L Sbjct: 342 --DYSKGKCLKT---YTGHKNEKYCIFANFSVT----GGKWIVSGSEDNLVYIWNLQTKE 392 Query: 482 VSEVKTIVHPAEITSVAFSNNGAFLVATD--QSRKVIPYS 519 + + K H + S A + + + + + Sbjct: 393 IVQ-KLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 431 Score = 165 bits (417), Expect = 5e-41, Method: Composition-based stats. Identities = 49/295 (16%), Positives = 103/295 (34%), Gaps = 22/295 (7%) Query: 27 TPAGDKIQYCNGTSVYTVPVGSLT--DTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVR 84 +P G+ + + + + G+ + + H + S S ++ Sbjct: 154 SPNGEWLASSSADKLIKI-WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLK 212 Query: 85 IWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLT 144 IWD + T+ S V +++ +S I V + ++ TG L Sbjct: 213 IWDVSSGK--CLKTLKGHSNYVFCCNFNPQSNLI--VSGSFDESVRIWDVKTGKCLKTLP 268 Query: 145 GQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTF-GEHTKFVHSVRYNPDGS 203 + +++V F I+S S D I++ + T + V V+++P+G Sbjct: 269 AHSDPVSAVHFNRDGSL-IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGK 327 Query: 204 LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGL--TWSPD-GTKIASASAD 260 + D T+ L++ G + H + + +S G I S S D Sbjct: 328 YILAATLDNTLKLWDYSKGKCLKTY-------TGHKNEKYCIFANFSVTGGKWIVSGSED 380 Query: 261 KTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISA--NGFINFVNPEL 313 + IWN+ T ++ + + T + T+ + S + + I + Sbjct: 381 NLVYIWNLQTKEIVQKLQGHTDVVIST-ACHPTENIIASAALENDKTIKLWKSDC 434 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 56/338 (16%), Positives = 112/338 (33%), Gaps = 52/338 (15%) Query: 279 VGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKT 338 G + + L S SA+ I G ++ GH I+ ++ S+D Sbjct: 142 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 201 Query: 339 LFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGS 398 L SA + + WD+S+G + H+ + F +++ ++ +G Sbjct: 202 LVSASDDKTLKIWDVSSGKCLKTLKG-HSNYV-----------FCCNFNPQSNLIVSG-- 247 Query: 399 GVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYN-SSCVALS 457 S D + + + + L +P + S V + Sbjct: 248 ---------------------SFDESVRIWD------VKTGKCLKTLPAHSDPVSAVHFN 280 Query: 458 NDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIP 517 D + D ++ + + ++ V FS NG +++A + Sbjct: 281 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 340 Query: 518 YSVANNFELAHTNSWTFHTAKVACVSWS---PDNVRLATGSLDNSVIVWNMNKPSDHPII 574 + + L ++T H + C+ + + +GS DN V +WN+ + + Sbjct: 341 WDYSKGKCL---KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ--TKEIVQ 395 Query: 575 IKGAHAMSSVNSVIWLNETTIVSAG--QDSNIKFWNVP 610 H +++ E I SA D IK W Sbjct: 396 KLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 433 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 43/263 (16%), Positives = 97/263 (36%), Gaps = 11/263 (4%) Query: 353 ISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSS 412 + + + H ++ +K + G+ S D K++ G+ + + Sbjct: 131 VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSAD--KLIKIWGAYDGKFEKTISGHKL 188 Query: 413 QPLGLAVSADGDIAVAACYKH---IAIYSHGKLTEV--PISYNSSCVALSNDKQFVAVGG 467 +A S+D ++ V+A I S GK + S C + + G Sbjct: 189 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS 248 Query: 468 QDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELA 527 D V ++ + + H +++V F+ +G+ +V++ + A+ L Sbjct: 249 FDESVRIWDVKTGKCLKTL-PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 307 Query: 528 HTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSV 587 V+ V +SP+ + +LDN++ +W+ +K + + + Sbjct: 308 TL--IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 365 Query: 588 IWLNE-TTIVSAGQDSNIKFWNV 609 + IVS +D+ + WN+ Sbjct: 366 FSVTGGKWIVSGSEDNLVYIWNL 388 >5FL8-q nrPDB Length = 515 Score = 255 bits (652), Expect = 3e-68, Method: Composition-based stats. Identities = 87/435 (20%), Positives = 157/435 (36%), Gaps = 64/435 (14%) Query: 138 TSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVR 197 S+ + G + F P R+++G+ DNT I++ T H +V V Sbjct: 134 RSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVS 193 Query: 198 YNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP-------D 250 ++PDG + A+ D TI L++ G G HS + L+W P Sbjct: 194 WSPDGEVIATGSMDNTIRLWDPKSGQCLGD------ALRGHSKWITSLSWEPIHLVKPGS 247 Query: 251 GTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA-LVSISANGFINFV 309 ++AS+S D TIKIW+ + + T+ T + + W Q L S S + + Sbjct: 248 KPRLASSSKDGTIKIWDTVSRVCQYTMSGHT---NSVSCVKWGGQGLLYSGSHDRTVRVW 304 Query: 310 NPEL-GSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHAT 368 + G + H + LS +ST + R+ H Sbjct: 305 DINSQGRCINILKSHAHWVNHLS---------------------LSTDYALRIGAFDH-- 341 Query: 369 MITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVA 428 TG K ++ + + +++ K+ G+ S + + + L +A Sbjct: 342 --TGKKPSTPEEAQKKALENYEKICKKNGN---SEEMMVTASDDYTMFLWNPLKSTKPIA 396 Query: 429 ACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTI 488 H + +H VA S D +++ D+ + ++ Sbjct: 397 RMTGHQKLVNH--------------VAFSPDGRYIVSASFDNSIKLWDGRDGKFISTF-R 441 Query: 489 VHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDN 548 H A + VA+S++ LV+ + + + V + H +V V WS D Sbjct: 442 GHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTR---KLSVDLPGHKDEVYTVDWSVDG 498 Query: 549 VRLATGSLDNSVIVW 563 R+ +G D V +W Sbjct: 499 KRVCSGGKDKMVRLW 513 Score = 193 bits (489), Expect = 3e-49, Method: Composition-based stats. Identities = 76/411 (18%), Positives = 159/411 (38%), Gaps = 26/411 (6%) Query: 211 DGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD-GTKIASASADKTIKIWNVA 269 D +LY K S H ++ ++P +++ + + D T +IW+ Sbjct: 115 DQITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCD 174 Query: 270 TLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSI-DQVRYGHNKAIT 328 T T+ G + + + + S + I +P+ G GH+K IT Sbjct: 175 TQTPMHTLK-GHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWIT 233 Query: 329 ALSSSA-----DGK--TLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDL 381 +LS G L S+ +G I WD + + + H ++ +K +G L Sbjct: 234 SLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVC-QYTMSGHTNSVSCVKWGGQGLL 292 Query: 382 FTVSWDDHLKVV--PAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACY--KHIAIY 437 ++ S D ++V + G ++ K+ A+ ++ L++S D + + A Sbjct: 293 YSGSHDRTVRVWDINSQGRCINILKSHAHWVNH----LSLSTDYALRIGAFDHTGKKPST 348 Query: 438 SHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSV 497 + +Y C N ++ + D + ++ ++ + H + V Sbjct: 349 PEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHV 408 Query: 498 AFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLD 557 AFS +G ++V+ + + + ++ ++ H A V V+WS D L + S D Sbjct: 409 AFSPDGRYIVSASFDNSIKLWDGRDGKFIS---TFRGHVASVYQVAWSSDCRLLVSCSKD 465 Query: 558 NSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWL-NETTIVSAGQDSNIKFW 607 ++ VW++ + + V +V W + + S G+D ++ W Sbjct: 466 TTLKVWDVRT---RKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 60/342 (17%), Positives = 116/342 (33%), Gaps = 55/342 (16%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS- 113 H + SP G A+G + +R+WD ++ L + S + +SW+ Sbjct: 182 LKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWD-PKSGQCLGDALRGHSKWITSLSWEPI 240 Query: 114 ----ESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDD 169 + ++ ++ + ++G +++ V + + SGS D Sbjct: 241 HLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKW--GGQGLLYSGSHD 298 Query: 170 NTVAIFEGPP-FKFKSTFGEHTKFVHSV-----------RYNPDGS-------------- 203 TV +++ + + H +V+ + ++ G Sbjct: 299 RTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALE 358 Query: 204 --------------LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP 249 + + D T+ L+N + TK + H V + +SP Sbjct: 359 NYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTK------PIARMTGHQKLVNHVAFSP 412 Query: 250 DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFV 309 DG I SAS D +IK+W+ K T G Q+ + LVS S + + Sbjct: 413 DGRYIVSASFDNSIKLWDGRDGKFISTF-RGHVASVYQVAWSSDCRLLVSCSKDTTLKVW 471 Query: 310 NPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 + + GH + + S DGK + S + + W Sbjct: 472 DVRTRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 183 bits (465), Expect = 2e-46, Method: Composition-based stats. Identities = 71/419 (16%), Positives = 133/419 (31%), Gaps = 61/419 (14%) Query: 25 GNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSP-SGYYCASGDVHGNV 83 G D+I + H + +P + +G Sbjct: 109 GYNSTEDQITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTA 168 Query: 84 RIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGN- 142 RIWD T + T+ V +SW + + IA + ++ +G G+ Sbjct: 169 RIWDCDTQTPMH--TLKGHYNWVLCVSWSPDGEVIATGS--MDNTIRLWDPKSGQCLGDA 224 Query: 143 LTGQARAMNSVDF------KPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSV 196 L G ++ + S+ + KP R+ S S D T+ I++ + T HT V V Sbjct: 225 LRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCV 284 Query: 197 RYNPDGSLFASTGGDGTIVLYNGVD-GTKTGVFEDDSLKNVAHSGSVFGLTWSPD----- 250 ++ G L S D T+ +++ G + + +H+ V L+ S D Sbjct: 285 KWGGQG-LLYSGSHDRTVRVWDINSQGRCINILK-------SHAHWVNHLSLSTDYALRI 336 Query: 251 ----------------------------------GTKIASASADKTIKIWNVATLKVEKT 276 + +AS D T+ +WN Sbjct: 337 GAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIA 396 Query: 277 IPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADG 336 G + + + +VS S + I + G GH ++ ++ S+D Sbjct: 397 RMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDC 456 Query: 337 KTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPA 395 + L S + + WD+ T + P H + + + G D + + Sbjct: 457 RLLVSCSKDTTLKVWDVRTRKLSVDLPG-HKDEVYTVDWSVDGKRVCSGGKDKMVRLWT 514 Score = 164 bits (414), Expect = 1e-40, Method: Composition-based stats. Identities = 71/428 (16%), Positives = 130/428 (30%), Gaps = 98/428 (22%) Query: 96 KTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDF 155 + I + ++ + G G + ++ DT T L G + V + Sbjct: 136 SSAIAGHGSTILCSAFAPHTSSRMVTGAG-DNTARIWDCDTQTPMHTLKGHYNWVLCVSW 194 Query: 156 KPSRPFRIISGSDDNTVAIFEGPPFKFKS-TFGEHTKFVHSVRYNPDG-------SLFAS 207 P I +GS DNT+ +++ + H+K++ S+ + P AS Sbjct: 195 SPDGEV-IATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLAS 253 Query: 208 TGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 + DGTI +++ V H+ SV + W G + S S D+T+++W+ Sbjct: 254 SSKDGTIKIWDTVSRVCQYTMS-------GHTNSVSCVKWGGQG-LLYSGSHDRTVRVWD 305 Query: 268 VATLKVEKTIPVGTRIEDQQLGIIW----------------------------------- 292 + + I L + Sbjct: 306 INSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICK 365 Query: 293 ----TKQALVSISANGFINFVNP-ELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGH 347 +++ +V+ S + + NP + GH K + ++ S DG+ + SA + Sbjct: 366 KNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNS 425 Query: 348 INSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVA 407 I WD G F H + + +S L D V + S Sbjct: 426 IKLWDGRDGKFISTFRG-HVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPG 484 Query: 408 NKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGG 467 +K V S D + V GG Sbjct: 485 HKDEVYT---------------------------------------VDWSVDGKRVCSGG 505 Query: 468 QDSKVHVY 475 +D V ++ Sbjct: 506 KDKMVRLW 513 Score = 148 bits (374), Expect = 5e-36, Method: Composition-based stats. Identities = 60/386 (15%), Positives = 117/386 (30%), Gaps = 79/386 (20%) Query: 265 IWNVATLKVEKTIPVGTRIEDQQLGIIW-TKQALVSISANGFINFVNPELGSIDQVRYGH 323 ++ V + + G T +V+ + + + + + GH Sbjct: 126 VFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGH 185 Query: 324 NKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFT 383 + +S S DG+ + + + I WD +G H+ IT + Sbjct: 186 YNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEP------ 239 Query: 384 VSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLT 443 K S+P + S DG I + + Y+ Sbjct: 240 ---------------------IHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMS--- 275 Query: 444 EVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFS--- 500 + + SCV + G D V V+ ++ H + ++ S Sbjct: 276 --GHTNSVSCVKWGGQG-LLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDY 332 Query: 501 ------------------------------------NNGAFLVATDQSRKVIPYSVANNF 524 N+ +V + ++ + Sbjct: 333 ALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKST 392 Query: 525 ELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSV 584 + T H V V++SPD + + S DNS+ +W+ D I ++SV Sbjct: 393 K--PIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGR---DGKFISTFRGHVASV 447 Query: 585 NSVIWLNET-TIVSAGQDSNIKFWNV 609 V W ++ +VS +D+ +K W+V Sbjct: 448 YQVAWSSDCRLLVSCSKDTTLKVWDV 473 >2H9P-A nrPDB Length = 329 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 70/302 (23%), Positives = 126/302 (41%), Gaps = 17/302 (5%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSE 114 H+ + K SP+G + AS ++IW + TI + D++W S+ Sbjct: 36 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--FEKTISGHKLGISDVAWSSD 93 Query: 115 SKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAI 174 S + + + + ++ +G L G + + +F P + I+SGS D +V I Sbjct: 94 SNLLVSASDDK--TLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRI 150 Query: 175 FEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLK 234 ++ K T H+ V +V +N DGSL S+ DG +++ G DD Sbjct: 151 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 210 Query: 235 NVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWT- 293 V + +SP+G I +A+ D T+K+W+ + K KT G + E + ++ Sbjct: 211 ------PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY-TGHKNEKYCIFANFSV 263 Query: 294 --KQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSAD--AEGHIN 349 + +VS S + + N + I Q GH + + + + SA + I Sbjct: 264 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIK 323 Query: 350 SW 351 W Sbjct: 324 LW 325 Score = 218 bits (554), Expect = 6e-57, Method: Composition-based stats. Identities = 67/344 (19%), Positives = 126/344 (36%), Gaps = 47/344 (13%) Query: 178 PPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 P + K T HTK V SV+++P+G AS+ D I ++ DG Sbjct: 28 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-------G 80 Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQAL 297 H + + WS D + SAS DKT+KIW+V++ K KT+ G + Sbjct: 81 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK-GHSNYVFCCNFNPQSNLI 139 Query: 298 VSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGI 357 VS S + + + + G + H+ ++A+ + DG + S+ +G WD ++G Sbjct: 140 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 199 Query: 358 SNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGL 417 + D ++ +K + G + D+ + G Sbjct: 200 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG------------------ 241 Query: 418 AVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKL 477 K + Y+ K + I N S +++ G +D+ V+++ L Sbjct: 242 --------------KCLKTYTGHKNEKYCIFANFSVT----GGKWIVSGSEDNLVYIWNL 283 Query: 478 SGASVSEVKTIVHPAEITSVAFSNNGAFLVATD--QSRKVIPYS 519 + + K H + S A + + + + + Sbjct: 284 QTKEIVQ-KLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 326 Score = 156 bits (395), Expect = 2e-38, Method: Composition-based stats. Identities = 49/295 (16%), Positives = 103/295 (34%), Gaps = 22/295 (7%) Query: 27 TPAGDKIQYCNGTSVYTVPVGSLT--DTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVR 84 +P G+ + + + + G+ + + H + S S ++ Sbjct: 49 SPNGEWLASSSADKLIKI-WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLK 107 Query: 85 IWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLT 144 IWD + T+ S V +++ +S I V + ++ TG L Sbjct: 108 IWDVSSGK--CLKTLKGHSNYVFCCNFNPQSNLI--VSGSFDESVRIWDVKTGKCLKTLP 163 Query: 145 GQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTF-GEHTKFVHSVRYNPDGS 203 + +++V F I+S S D I++ + T + V V+++P+G Sbjct: 164 AHSDPVSAVHFNRDGSL-IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGK 222 Query: 204 LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGL--TWSPD-GTKIASASAD 260 + D T+ L++ G + H + + +S G I S S D Sbjct: 223 YILAATLDNTLKLWDYSKGKCLKTY-------TGHKNEKYCIFANFSVTGGKWIVSGSED 275 Query: 261 KTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISA--NGFINFVNPEL 313 + IWN+ T ++ + + T + T+ + S + + I + Sbjct: 276 NLVYIWNLQTKEIVQKLQGHTDVVIST-ACHPTENIIASAALENDKTIKLWKSDC 329 Score = 151 bits (380), Expect = 1e-36, Method: Composition-based stats. Identities = 56/338 (16%), Positives = 112/338 (33%), Gaps = 52/338 (15%) Query: 279 VGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKT 338 G + + L S SA+ I G ++ GH I+ ++ S+D Sbjct: 37 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 96 Query: 339 LFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGS 398 L SA + + WD+S+G + H+ + F +++ ++ +G Sbjct: 97 LVSASDDKTLKIWDVSSGKCLKTLKG-HSNYV-----------FCCNFNPQSNLIVSG-- 142 Query: 399 GVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYN-SSCVALS 457 S D + + + + L +P + S V + Sbjct: 143 ---------------------SFDESVRIWD------VKTGKCLKTLPAHSDPVSAVHFN 175 Query: 458 NDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIP 517 D + D ++ + + ++ V FS NG +++A + Sbjct: 176 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 235 Query: 518 YSVANNFELAHTNSWTFHTAKVACVSWS---PDNVRLATGSLDNSVIVWNMNKPSDHPII 574 + + L ++T H + C+ + + +GS DN V +WN+ + + Sbjct: 236 WDYSKGKCL---KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ--TKEIVQ 290 Query: 575 IKGAHAMSSVNSVIWLNETTIVSAG--QDSNIKFWNVP 610 H +++ E I SA D IK W Sbjct: 291 KLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 328 Score = 117 bits (293), Expect = 1e-26, Method: Composition-based stats. Identities = 43/263 (16%), Positives = 97/263 (36%), Gaps = 11/263 (4%) Query: 353 ISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSS 412 + + + H ++ +K + G+ S D K++ G+ + + Sbjct: 26 VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSAD--KLIKIWGAYDGKFEKTISGHKL 83 Query: 413 QPLGLAVSADGDIAVAACYKH---IAIYSHGKLTEV--PISYNSSCVALSNDKQFVAVGG 467 +A S+D ++ V+A I S GK + S C + + G Sbjct: 84 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS 143 Query: 468 QDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELA 527 D V ++ + + H +++V F+ +G+ +V++ + A+ L Sbjct: 144 FDESVRIWDVKTGKCLKTL-PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 202 Query: 528 HTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSV 587 V+ V +SP+ + +LDN++ +W+ +K + + + Sbjct: 203 TL--IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 260 Query: 588 IWLNE-TTIVSAGQDSNIKFWNV 609 + IVS +D+ + WN+ Sbjct: 261 FSVTGGKWIVSGSEDNLVYIWNL 283 >5MZH-A nrPDB Length = 452 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 77/395 (19%), Positives = 143/395 (36%), Gaps = 22/395 (5%) Query: 3 EFSQTALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQT 62 E + + P + PA ++ + + S T ++ H Sbjct: 44 EVLLSQIIRQEPLISENR------RPALRQLIHRLIDKMLEQQHHSFTLFKVLRAHILPL 97 Query: 63 TVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISW-DSESKRIAAV 121 T + SG +G ++W+T + T+ V I++ + +I Sbjct: 98 TNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVF--TLEGHKNVVYAIAFNNPYGDKIVTG 155 Query: 122 GEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFK 181 + ++ TG L G + + F P + I +GS DNT +++ + Sbjct: 156 SFDK--TCKLWDAYTGQLYYTLKGHQTEIVCLSFNP-QSTIIATGSMDNTAKLWDVETGQ 212 Query: 182 FKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGS 241 ++T H + S+ +N G L + D L++ G V H G Sbjct: 213 ERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLS-------GHRGE 265 Query: 242 VFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSIS 301 V ++ GT + S S D T ++W+V + + ++ G E + +VS S Sbjct: 266 VSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCL-SVKQGHTDEVLDVAFDAAGTKMVSAS 324 Query: 302 ANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRV 361 A+G + G GH I+ ++ + G L +A ++ WD TG +V Sbjct: 325 ADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQV 384 Query: 362 FPDVHATMITGIKTTSKGD-LFTVSWDDHLKVVPA 395 H I +GD + T S D+ ++ A Sbjct: 385 LEG-HTDEIFSCAFNYEGDFIITGSKDNTCRIWKA 418 Score = 227 bits (579), Expect = 9e-60, Method: Composition-based stats. Identities = 58/293 (19%), Positives = 112/293 (38%), Gaps = 18/293 (6%) Query: 26 NTPAGDKI---QYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGN 82 N P GDKI + ++ G L T H + +P A+G + Sbjct: 145 NNPYGDKIVTGSFDKTCKLWDAYTGQLYYT--LKGHQTEIVCLSFNPQSTIIATGSMDNT 202 Query: 83 VRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGN 142 ++WD T + T+ + + +++ I + ++ TG Sbjct: 203 AKLWDVE--TGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHD--SRLWDVRTGQCVHV 258 Query: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDG 202 L+G ++S F + ++SGS D T +++ + S HT V V ++ G Sbjct: 259 LSGHRGEVSSTQFNYAGTL-VVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAG 317 Query: 203 SLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKT 262 + S DG+ LY+ + G V H G + + ++P GT++ +AS+DKT Sbjct: 318 TKMVSASADGSARLYHTLTGVCQHTL-------VGHEGEISKVAFNPQGTRLITASSDKT 370 Query: 263 IKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGS 315 ++W+ T + + + G E + +++ S + S Sbjct: 371 CRLWDCDTGECLQVLE-GHTDEIFSCAFNYEGDFIITGSKDNTCRIWKALTAS 422 Score = 214 bits (545), Expect = 8e-56, Method: Composition-based stats. Identities = 67/400 (16%), Positives = 136/400 (34%), Gaps = 54/400 (13%) Query: 84 RIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNL 143 ++ + + L + P+ + +++ R +R V+ TG L Sbjct: 75 KMLEQQHHSFTLFKVLRAHILPLTNCAFNKSGDRFITGS--YDRTCKVWNTFTGEEVFTL 132 Query: 144 TGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGS 203 G + ++ F +I++GS D T +++ + T H + + +NP + Sbjct: 133 EGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQST 192 Query: 204 LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTI 263 + A+ D T L++ G + H + L ++ G I + S D Sbjct: 193 IIATGSMDNTAKLWDVETGQERATL-------AGHRAEIVSLGFNTGGDLIVTGSFDHDS 245 Query: 264 KIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGH 323 ++W+V T + + G R E + +VS S + + G V+ GH Sbjct: 246 RLWDVRTGQCVHVLS-GHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGH 304 Query: 324 NKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKG-DLF 382 + ++ A G + SA A+G + TG+ H I+ + +G L Sbjct: 305 TDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVG-HEGEISKVAFNPQGTRLI 363 Query: 383 TVSWDDHLKVV-PAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGK 441 T S D ++ G + + +++ S Sbjct: 364 TASSDKTCRLWDCDTGECLQVLEGHTDEIFS----------------------------- 394 Query: 442 LTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGAS 481 A + + F+ G +D+ ++K AS Sbjct: 395 ------------CAFNYEGDFIITGSKDNTCRIWKALTAS 422 Score = 210 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 65/354 (18%), Positives = 116/354 (32%), Gaps = 24/354 (6%) Query: 178 PPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 F H + + +N G F + D T ++N G + E Sbjct: 82 HSFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLE-------G 134 Query: 238 HSGSVFGLTW-SPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA 296 H V+ + + +P G KI + S DKT K+W+ T ++ T+ G + E L Sbjct: 135 HKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLK-GHQTEIVCLSFNPQSTI 193 Query: 297 LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 + + S + + E G GH I +L + G + + + WD+ TG Sbjct: 194 IATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTG 253 Query: 357 ISNRVFPDVHATMITGIKTTSKG--------DLFTVSWDDHLKVVPAGGSGVDSSKAVAN 408 V H ++ + G D + WD + G Sbjct: 254 QCVHVLSG-HRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVA 312 Query: 409 KLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQ 468 ++ ++ SADG + + + + T V S VA + + Sbjct: 313 FDAAGTKMVSASADGSARL-----YHTLTGVCQHTLVGHEGEISKVAFNPQGTRLITASS 367 Query: 469 DSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVAN 522 D ++ +V H EI S AF+ G F++ + + Sbjct: 368 DKTCRLWDCDTGECLQVLE-GHTDEIFSCAFNYEGDFIITGSKDNTCRIWKALT 420 Score = 193 bits (489), Expect = 3e-49, Method: Composition-based stats. Identities = 59/332 (17%), Positives = 106/332 (31%), Gaps = 10/332 (3%) Query: 237 AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA 296 AH + ++ G + + S D+T K+WN T + T+ + Sbjct: 92 AHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGDK 151 Query: 297 LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 +V+ S + + G + GH I LS + + + + WD+ TG Sbjct: 152 IVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETG 211 Query: 357 ISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVP--AGGSGVDSSKAVANKLSSQP 414 H I + + GDL DH + G V ++SS Sbjct: 212 QERATLAG-HRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSSTQ 270 Query: 415 LGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSC--VALSNDKQFVAVGGQDSKV 472 A + ++ C + G+ V + VA + D Sbjct: 271 FNYAGTLVVSGSI-DCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSA 329 Query: 473 HVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSW 532 +Y H EI+ VAF+ G L+ + + L Sbjct: 330 RLYHTLTGVCQHTLV-GHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQ---VL 385 Query: 533 TFHTAKVACVSWSPDNVRLATGSLDNSVIVWN 564 HT ++ +++ + + TGS DN+ +W Sbjct: 386 EGHTDEIFSCAFNYEGDFIITGSKDNTCRIWK 417 Score = 149 bits (375), Expect = 4e-36, Method: Composition-based stats. Identities = 40/230 (17%), Positives = 85/230 (36%), Gaps = 10/230 (4%) Query: 18 RGTAVVLGNTPAGDKI---QYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYC 74 R V LG GD I + + + ++ V G + + H + + + + +G Sbjct: 221 RAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVH--VLSGHRGEVSSTQFNYAGTLV 278 Query: 75 ASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLF 134 SG + R+WD + + V D+++D+ ++ + ++ Sbjct: 279 VSGSIDCTSRLWDVRSGR--CLSVKQGHTDEVLDVAFDAAGTKMVSASADGS--ARLYHT 334 Query: 135 DTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVH 194 TG L G ++ V F P + R+I+ S D T +++ + HT + Sbjct: 335 LTGVCQHTLVGHEGEISKVAFNP-QGTRLITASSDKTCRLWDCDTGECLQVLEGHTDEIF 393 Query: 195 SVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFG 244 S +N +G + D T ++ + + + +A + F Sbjct: 394 SCAFNYEGDFIITGSKDNTCRIWKALTASSQPAGPGGAGGGLARPTTAFS 443 Score = 137 bits (345), Expect = 1e-32, Method: Composition-based stats. Identities = 41/324 (12%), Positives = 92/324 (28%), Gaps = 47/324 (14%) Query: 288 LGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSS-ADGKTLFSADAEG 346 + ++ S + N G GH + A++ + G + + + Sbjct: 100 CAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDK 159 Query: 347 HINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAV 406 WD TG H T I + + + D+ + +G + Sbjct: 160 TCKLWDAYTGQLYYTLKG-HQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQE----- 213 Query: 407 ANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVG 466 + T + + + G Sbjct: 214 ----------------------------------RATLAGHRAEIVSLGFNTGGDLIVTG 239 Query: 467 GQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFEL 526 D ++ + V + H E++S F+ G +V+ + V + L Sbjct: 240 SFDHDSRLWDVRTGQCVHVLS-GHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCL 298 Query: 527 AHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNS 586 + HT +V V++ ++ + S D S +++ ++ +S V Sbjct: 299 S---VKQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAF 355 Query: 587 VIWLNETTIVSAGQDSNIKFWNVP 610 T +++A D + W+ Sbjct: 356 N--PQGTRLITASSDKTCRLWDCD 377 Score = 119 bits (297), Expect = 4e-27, Method: Composition-based stats. Identities = 41/299 (13%), Positives = 89/299 (29%), Gaps = 51/299 (17%) Query: 312 ELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMIT 371 ++ +V H +T + + G + + W+ TG H ++ Sbjct: 82 HSFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEG-HKNVVY 140 Query: 372 GIKTTSK--GDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAA 429 I + + T S+D K+ + L + G Sbjct: 141 AIAFNNPYGDKIVTGSFDKTCKLW-----------------DAYTGQLYYTLKGH----- 178 Query: 430 CYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV 489 C++ + +A G D+ ++ + Sbjct: 179 ------------------QTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQERATL-AG 219 Query: 490 HPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNV 549 H AEI S+ F+ G +V + V + + H +V+ ++ Sbjct: 220 HRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTG---QCVHVLSGHRGEVSSTQFNYAGT 276 Query: 550 RLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWL-NETTIVSAGQDSNIKFW 607 + +GS+D + +W++ + V V + T +VSA D + + + Sbjct: 277 LVVSGSIDCTSRLWDVRSG---RCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLY 332 Score = 101 bits (252), Expect = 7e-22, Method: Composition-based stats. Identities = 27/159 (16%), Positives = 56/159 (35%), Gaps = 7/159 (4%) Query: 452 SCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFS-NNGAFLVATD 510 + A + G D V+ H + ++AF+ G +V Sbjct: 98 TNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLE-GHKNVVYAIAFNNPYGDKIVTGS 156 Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 + + + H ++ C+S++P + +ATGS+DN+ +W++ + Sbjct: 157 FDKTCKLWDAYTG---QLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDV--ETG 211 Query: 571 HPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 H V+ IV+ D + + W+V Sbjct: 212 QERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDV 250 >1VYH-C nrPDB Length = 410 Score = 234 bits (596), Expect = 8e-62, Method: Composition-based stats. Identities = 65/330 (19%), Positives = 124/330 (37%), Gaps = 25/330 (7%) Query: 237 AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA 296 H V + + P + + SAS D TIK+W+ T E+T+ G Q + + + Sbjct: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLK-GHTDSVQDISFDHSGKL 164 Query: 297 LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 L S SA+ I + + + +GH+ ++++S +G + SA + I W++ TG Sbjct: 165 LASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTG 224 Query: 357 ISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLG 416 + F H + ++ G L +D V V ++K +L Sbjct: 225 YCVKTFTG-HREWVRMVRPNQDGTLIASCSNDQTVRV-----WVVATKECKAELREHR-- 276 Query: 417 LAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYK 476 V C S+ ++E + S F+ G +D + ++ Sbjct: 277 ---------HVVECISWAPESSYSSISE---ATGSETKKSGKPGPFLLSGSRDKTIKMWD 324 Query: 477 LSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHT 536 +S H + V F + G F+++ + + + N + N+ H Sbjct: 325 VSTGMCLMTLV-GHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNA---HE 380 Query: 537 AKVACVSWSPDNVRLATGSLDNSVIVWNMN 566 V + + + TGS+D +V VW Sbjct: 381 HFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410 Score = 197 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 66/320 (20%), Positives = 106/320 (33%), Gaps = 38/320 (11%) Query: 139 SNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRY 198 L+G + V F P ++S S+D T+ +++ F+ T HT V + + Sbjct: 100 EKYALSGHRSPVTRVIFHPVFSV-MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISF 158 Query: 199 NPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASAS 258 + G L AS D TI L++ H +V ++ P+G I SAS Sbjct: 159 DHSGKLLASCSADMTIKLWDFQGFECIRTMH-------GHDHNVSSVSIMPNGDHIVSAS 211 Query: 259 ADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQ 318 DKTIK+W V T KT G R + + + S S + + Sbjct: 212 RDKTIKMWEVQTGYCVKTF-TGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKA 270 Query: 319 VRYGHNKAITALSSSADGKT--------------------LFSADAEGHINSWDISTGIS 358 H + +S + + L S + I WD+STG+ Sbjct: 271 ELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMC 330 Query: 359 NRVFPDVHATMITGIKTTSKGDLFTVS--------WDDHLKVVPAGGSGVDSSKAVANKL 410 H + G+ S G WD K + + + Sbjct: 331 LMTLVG-HDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFH 389 Query: 411 SSQPLGLAVSADGDIAVAAC 430 + P + S D + V C Sbjct: 390 KTAPYVVTGSVDQTVKVWEC 409 Score = 181 bits (460), Expect = 6e-46, Method: Composition-based stats. Identities = 56/332 (16%), Positives = 97/332 (29%), Gaps = 39/332 (11%) Query: 7 TALFPSLP-----RTARGTAVVLGNTPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSH 60 P P R + P + + + V + H+ Sbjct: 92 KEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTD 151 Query: 61 QTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAA 120 SG AS +++WD T+ V +S I + Sbjct: 152 SVQDISFDHSGKLLASCSADMTIKLWD--FQGFECIRTMHGHDHNVSSVSIMPNGDHIVS 209 Query: 121 VGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPF 180 R++ ++ TG TG + V I S S+D TV ++ Sbjct: 210 AS--RDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTL-IASCSNDQTVRVWVVATK 266 Query: 181 KFKSTFGEHTKFVHSVRYNPD--------------------GSLFASTGGDGTIVLYNGV 220 + K+ EH V + + P+ G S D TI +++ Sbjct: 267 ECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVS 326 Query: 221 DGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVG 280 G V H V G+ + G I S + DKT+++W+ + KT+ Sbjct: 327 TGMCLMTL-------VGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAH 379 Query: 281 TRIEDQQLGIIWTKQALVSISANGFINFVNPE 312 L T +V+ S + + Sbjct: 380 EHF-VTSLDFHKTAPYVVTGSVDQTVKVWECR 410 Score = 141 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 51/351 (14%), Positives = 105/351 (29%), Gaps = 68/351 (19%) Query: 279 VGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKT 338 G R ++ +VS S + I + E G ++ GH ++ +S GK Sbjct: 105 SGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKL 164 Query: 339 LFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGD-LFTVSWDDHLKVVPAGG 397 L S A+ I WD R H ++ + GD + + S D +K+ Sbjct: 165 LASCSADMTIKLWDFQGFECIRTMHG-HDHNVSSVSIMPNGDHIVSASRDKTIKMW---- 219 Query: 398 SGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALS 457 Q + G + + Sbjct: 220 -------------EVQTGYCVKTFTGHREWVRMVRP-----------------------N 243 Query: 458 NDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNN--------------- 502 D +A D V V+ ++ + H + ++++ Sbjct: 244 QDGTLIASCSNDQTVRVWVVATKECKA-ELREHRHVVECISWAPESSYSSISEATGSETK 302 Query: 503 -----GAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLD 557 G FL++ + + + + V+ L + H V V + + + + D Sbjct: 303 KSGKPGPFLLSGSRDKTIKMWDVSTGMCL---MTLVGHDNWVRGVLFHSGGKFILSCADD 359 Query: 558 NSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 ++ VW+ + H ++S++ +V+ D +K W Sbjct: 360 KTLRVWDYKNKRCMKTLNAHEHFVTSLDFHK--TAPYVVTGSVDQTVKVWE 408 Score = 99.2 bits (245), Expect = 4e-21, Method: Composition-based stats. Identities = 33/197 (16%), Positives = 67/197 (34%), Gaps = 24/197 (12%) Query: 433 HIAIYSHGKLTEVPISYNSSCVALSND--KQFVAVGGQDSKVHVYKLSGASVSEVKTIVH 490 + Y G + S +S D + +A D + ++ G H Sbjct: 133 KVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTM-HGH 191 Query: 491 PAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVR 550 ++SV+ NG +V+ + + + + V + ++T H V V + D Sbjct: 192 DHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTGY---CVKTFTGHREWVRMVRPNQDGTL 248 Query: 551 LATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWL------------------NE 592 +A+ S D +V VW + + + H + ++ Sbjct: 249 IASCSNDQTVRVWVVATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPG 308 Query: 593 TTIVSAGQDSNIKFWNV 609 ++S +D IK W+V Sbjct: 309 PFLLSGSRDKTIKMWDV 325 Score = 83.0 bits (203), Expect = 3e-16, Method: Composition-based stats. Identities = 28/121 (23%), Positives = 49/121 (40%), Gaps = 5/121 (4%) Query: 489 VHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDN 548 H + +T V F + +V+ + + + + HT V +S+ Sbjct: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFE---RTLKGHTDSVQDISFDHSG 162 Query: 549 VRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 LA+ S D ++ +W+ + H +SSV+ + N IVSA +D IK W Sbjct: 163 KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIM--PNGDHIVSASRDKTIKMWE 220 Query: 609 V 609 V Sbjct: 221 V 221 Score = 57.2 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 13/77 (16%), Positives = 29/77 (37%), Gaps = 2/77 (2%) Query: 532 WTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLN 591 + H + V V + P + + S D ++ VW+ + ++ ++ + Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFD--HS 161 Query: 592 ETTIVSAGQDSNIKFWN 608 + S D IK W+ Sbjct: 162 GKLLASCSADMTIKLWD 178 >3DM0-A nrPDB Length = 694 Score = 231 bits (589), Expect = 7e-61, Method: Composition-based stats. Identities = 75/305 (24%), Positives = 131/305 (42%), Gaps = 45/305 (14%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSE 114 T HSH S G + SG G +R+WD + + V +++ + Sbjct: 426 LTGHSHFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRR--FVGHTKDVLSVAFSLD 483 Query: 115 SKRIAAVGEGRERFGHVFLFDT-GTSNGNLT----GQARAMNSVDFKPSR-PFRIISGSD 168 +++I + R + L++T G ++ G ++ V F P+ I+S S Sbjct: 484 NRQIVSASRDRT----IKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASW 539 Query: 169 DNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVF 228 D TV ++ K +ST HT +V +V +PDGSL AS G DG ++L++ +G K Sbjct: 540 DKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSL 599 Query: 229 EDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQL 288 E +S+ + L +SP+ + +A+ IKIW++ + + + + V + E ++ Sbjct: 600 EANSV--------IHALCFSPNRYWLCAATEHG-IKIWDLESKSIVEDLKVDLKAEAEKA 650 Query: 289 GIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHI 348 + + + I T+L+ SADG TLFS +G I Sbjct: 651 D-----NSGPAATKRKVI-------------------YCTSLNWSADGSTLFSGYTDGVI 686 Query: 349 NSWDI 353 W I Sbjct: 687 RVWGI 691 Score = 194 bits (493), Expect = 8e-50, Method: Composition-based stats. Identities = 62/350 (17%), Positives = 119/350 (34%), Gaps = 41/350 (11%) Query: 138 TSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFK-----FKSTFGEHTKF 192 G + + ++ I+S S D ++ +++ + H+ F Sbjct: 373 VLKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHF 432 Query: 193 VHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGT 252 V V + DG S DG + L++ G T F V H+ V + +S D Sbjct: 433 VEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRF-------VGHTKDVLSVAFSLDNR 485 Query: 253 KIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW-----TKQALVSISANGFIN 307 +I SAS D+TIK+WN + + TI G + + + +VS S + + Sbjct: 486 QIVSASRDRTIKLWNTL-GECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVK 544 Query: 308 FVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHA 367 N + GH ++ ++ S DG S +G + WD++ G Sbjct: 545 VWNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLE--AN 602 Query: 368 TMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAV 427 ++I + + + + +K+ + V K ++ + A V Sbjct: 603 SVIHALCFSPNRYWLCAATEHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKV 662 Query: 428 AACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKL 477 C + + S D + G D + V+ + Sbjct: 663 IYC---------------------TSLNWSADGSTLFSGYTDGVIRVWGI 691 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 64/269 (23%), Positives = 105/269 (39%), Gaps = 16/269 (5%) Query: 94 ILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVF-----LFDTGTSNGNLTGQAR 148 +LK T+ + V I+ ++ I V R++ ++ G + LTG + Sbjct: 373 VLKGTMRAHTDMVTAIATPIDNADII-VSASRDKSIILWKLTKDDKAYGVAQRRLTGHSH 431 Query: 149 AMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFAST 208 + V F + SGS D + +++ F HTK V SV ++ D S Sbjct: 432 FVEDVVLSSDGQFAL-SGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSA 490 Query: 209 GGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD--GTKIASASADKTIKIW 266 D TI L+N + G + H V + +SP+ I SAS DKT+K+W Sbjct: 491 SRDRTIKLWNTL-GECKYTISE---GGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVW 546 Query: 267 NVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKA 326 N++ K+ T+ G + + S +G + + G N Sbjct: 547 NLSNCKLRSTL-AGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEA-NSV 604 Query: 327 ITALSSSADGKTLFSADAEGHINSWDIST 355 I AL S + L +A G I WD+ + Sbjct: 605 IHALCFSPNRYWLCAATEHG-IKIWDLES 632 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 58/335 (17%), Positives = 113/335 (33%), Gaps = 61/335 (18%) Query: 276 TIPVGTRIEDQQLGIIWTKQALVSISANGFINFV-----NPELGSIDQVRYGHNKAITAL 330 T+ T + I +VS S + I + G + GH+ + + Sbjct: 377 TMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDV 436 Query: 331 SSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTT-SKGDLFTVSWDDH 389 S+DG+ S +G + WD++ G+S R F H + + + + + S D Sbjct: 437 VLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVG-HTKDVLSVAFSLDNRQIVSASRDRT 495 Query: 390 LKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYK------HIAIYSHGKLT 443 +K+ G ++ +G +C + I S Sbjct: 496 IKLWNTLGEC--------------KYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDK 541 Query: 444 EVPISYNSSC---------------VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTI 488 V + S+C VA+S D A GG+D V ++ L+ + ++ Sbjct: 542 TVKVWNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKK--LYSL 599 Query: 489 VHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAK---------- 538 + I ++ FS N +L A + + + + + + A+ Sbjct: 600 EANSVIHALCFSPNRYWLCAATE-HGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAAT 658 Query: 539 ------VACVSWSPDNVRLATGSLDNSVIVWNMNK 567 ++WS D L +G D + VW + + Sbjct: 659 KRKVIYCTSLNWSADGSTLFSGYTDGVIRVWGIGR 693 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 50/304 (16%), Positives = 107/304 (35%), Gaps = 57/304 (18%) Query: 316 IDQVRYGHNKAITALSSSADG-KTLFSADAEGHINSWDISTGISN----RVFPDVHATMI 370 + H +TA+++ D + SA + I W ++ + H+ + Sbjct: 374 LKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFV 433 Query: 371 TGIKTTSKGD-LFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAA 429 + +S G + SWD L++ +GV + Sbjct: 434 EDVVLSSDGQFALSGSWDGELRL-WDLAAGVST--------------------------- 465 Query: 430 CYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKT-- 487 V + + VA S D + + +D + ++ G + Sbjct: 466 ------------RRFVGHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTLGECKYTISEGG 513 Query: 488 IVHPAEITSVAFSNN--GAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWS 545 H ++ V FS N +V+ + V ++++N ++ HT V+ V+ S Sbjct: 514 EGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSN---CKLRSTLAGHTGYVSTVAVS 570 Query: 546 PDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIK 605 PD A+G D V++W++ + + A S ++++ + + A + IK Sbjct: 571 PDGSLCASGGKDGVVLLWDLAEGKK----LYSLEANSVIHALCFSPNRYWLCAATEHGIK 626 Query: 606 FWNV 609 W++ Sbjct: 627 IWDL 630 Score = 118 bits (296), Expect = 6e-27, Method: Composition-based stats. Identities = 34/228 (14%), Positives = 72/228 (31%), Gaps = 16/228 (7%) Query: 52 TEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTH-ILKTTIPVFSGPVKDIS 110 T + H+ S S +++W+T + V + Sbjct: 465 TRRFVGHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVR 524 Query: 111 WDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDN 170 + + + V ++ V+ L G +++V P SG D Sbjct: 525 FSPNTLQPTIVSASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSPDGSLC-ASGGKDG 583 Query: 171 TVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVF-- 228 V +++ K + +H++ ++P+ + G I +++ + Sbjct: 584 VVLLWDLAEGKKLYSLEA-NSVIHALCFSPNRYWLCAATEHG-IKIWDLESKSIVEDLKV 641 Query: 229 -------EDDSLKNVAHSGSV---FGLTWSPDGTKIASASADKTIKIW 266 + D+ A V L WS DG+ + S D I++W Sbjct: 642 DLKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLFSGYTDGVIRVW 689 Score = 69.5 bits (168), Expect = 4e-12, Method: Composition-based stats. Identities = 32/190 (16%), Positives = 57/190 (30%), Gaps = 32/190 (16%) Query: 28 PAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWD 87 P + V+ + L T H+ + SP G CASG G V +WD Sbjct: 532 PTIVSASWDKTVKVWNLSNCKLRST--LAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWD 589 Query: 88 TTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQA 147 + + + + + + A E ++ ++ + +L Sbjct: 590 LAEGKKLYSLEANSV---IHALCFSPNRYWLCAA---TEHGIKIWDLESKSIVEDLK--- 640 Query: 148 RAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFAS 207 VD K SG + + S+ ++ DGS S Sbjct: 641 -----VDLKAEAEKADNSG----------------PAATKRKVIYCTSLNWSADGSTLFS 679 Query: 208 TGGDGTIVLY 217 DG I ++ Sbjct: 680 GYTDGVIRVW 689 >5NNZ-B nrPDB Length = 415 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 75/467 (16%), Positives = 149/467 (31%), Gaps = 67/467 (14%) Query: 20 TAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVA-KTSPSGYYCASGD 78 +++L P G ++Y L D T+ S K P + Sbjct: 4 KSLLLRYYPPGIMLEYEKH-GELKTKSIDLLDLGPSTDVSALVEEIQKAEP----LLTAS 58 Query: 79 VHGNVRIW----------DTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERF 128 V++ ++ T ++ K + P+ +++ + +R Sbjct: 59 RTEQVKLLIQRLQEKLGQNSNHTFYLFKV-LKAHILPLTNVALNKSGSCFITGS--YDRT 115 Query: 129 GHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGE 188 ++ +G L G + ++ F +I +GS D T ++ K TF Sbjct: 116 CKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRG 175 Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 HT + + +NP +L A+ D T L++ +G + HS + L+++ Sbjct: 176 HTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR-------GHSAEIISLSFN 228 Query: 249 PDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINF 308 G +I + S D T+ +W+ T + + I +G E W +++ S + Sbjct: 229 TSGDRIITGSFDHTVVVWDADTGR-KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKL 287 Query: 309 VNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHAT 368 + G GH+ I GK + +A A+G + +T H Sbjct: 288 WDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEG-HEG 346 Query: 369 MITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVA 428 I+ I +G+ D + +G +G Sbjct: 347 EISKISFNPQGNHLLTGSSDKTARIWDAQTGQ----------------CLQVLEGHTD-- 388 Query: 429 ACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVY 475 I+S A + V G +D+ ++ Sbjct: 389 ------EIFSC---------------AFNYKGNIVITGSKDNTCRIW 414 Score = 194 bits (493), Expect = 8e-50, Method: Composition-based stats. Identities = 52/287 (18%), Positives = 95/287 (33%), Gaps = 59/287 (20%) Query: 26 NTPAGDKIQ---YCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGN 82 N P GDKI + +++V G T + H+ + +P A+G + Sbjct: 143 NNPYGDKIATGSFDKTCKLWSVETGKCYHT--FRGHTAEIVCLSFNPQSTLVATGSMDTT 200 Query: 83 VRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGN 142 ++WD + T+ S + +S+++ RI V+ DTG Sbjct: 201 AKLWDIQNGEEVY--TLRGHSAEIISLSFNTSGDRIITGSFDHTVV--VWDADTGRKVNI 256 Query: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHS------- 195 L G ++S F I++GS D T +++ K +T H + Sbjct: 257 LIGHCAEISSASFNWDCSL-ILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTG 315 Query: 196 -----------------------------------VRYNPDGSLFASTGGDGTIVLYNGV 220 + +NP G+ + D T +++ Sbjct: 316 KLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQ 375 Query: 221 DGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 G V E H+ +F ++ G + + S D T +IW Sbjct: 376 TGQCLQVLE-------GHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415 Score = 184 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 56/349 (16%), Positives = 113/349 (32%), Gaps = 16/349 (4%) Query: 222 GTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGT 281 G + AH + + + G+ + S D+T K+W+ A+ + T+ Sbjct: 75 GQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHR 134 Query: 282 RIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFS 341 + + + S + + E G GH I LS + + + Sbjct: 135 NVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVAT 194 Query: 342 ADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVP--AGGSG 399 + WDI G H+ I + + GD DH VV G Sbjct: 195 GSMDTTAKLWDIQNGEEVYTLRG-HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRK 253 Query: 400 VDSSKAVANKLSSQPLGLAVSADGDIAVAACYK---HIAIYSHGKLTEVPISYNSSCV-- 454 V+ ++SS + + D + + + ++GK ++ + Sbjct: 254 VNILIGHCAEISS----ASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDS 309 Query: 455 ALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRK 514 + +A D ++ + K H EI+ ++F+ G L+ + Sbjct: 310 CFDYTGKLIATASADGTARIFSAATRKCIA-KLEGHEGEISKISFNPQGNHLLTGSSDKT 368 Query: 515 VIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVW 563 + L HT ++ +++ + TGS DN+ +W Sbjct: 369 ARIWDAQTGQCLQ---VLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 39/323 (12%), Positives = 94/323 (29%), Gaps = 49/323 (15%) Query: 288 LGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSS-ADGKTLFSADAEG 346 + + + ++ S + + G GH + A++ + G + + + Sbjct: 98 VALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDK 157 Query: 347 HINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAV 406 W + TG F H I + + L D + +G + Sbjct: 158 TCKLWSVETGKCYHTFRG-HTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEE----- 211 Query: 407 ANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVG 466 + G A ++ + + G Sbjct: 212 -----------VYTLRGHSA-----------------------EIISLSFNTSGDRIITG 237 Query: 467 GQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFEL 526 D V V+ + I H AEI+S +F+ + + ++ + + N Sbjct: 238 SFDHTVVVWDADTGRKVNIL-IGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNG--- 293 Query: 527 AHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNS 586 + T H ++ + +AT S D + +++ I K ++ Sbjct: 294 KCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAAT---RKCIAKLEGHEGEISK 350 Query: 587 VIWLNE-TTIVSAGQDSNIKFWN 608 + + + +++ D + W+ Sbjct: 351 ISFNPQGNHLLTGSSDKTARIWD 373 Score = 142 bits (357), Expect = 5e-34, Method: Composition-based stats. Identities = 36/198 (18%), Positives = 69/198 (34%), Gaps = 6/198 (3%) Query: 22 VVLGNTPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVH 80 + L +GD+I + V + I H + + A + +G + Sbjct: 223 ISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMD 282 Query: 81 GNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSN 140 ++WD T T+ + D +D K IA +F T Sbjct: 283 KTCKLWDATNGK--CVATLTGHDDEILDSCFDYTGKLIATASADG--TARIFSAATRKCI 338 Query: 141 GNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNP 200 L G ++ + F P + +++GS D T I++ + HT + S +N Sbjct: 339 AKLEGHEGEISKISFNP-QGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNY 397 Query: 201 DGSLFASTGGDGTIVLYN 218 G++ + D T ++ Sbjct: 398 KGNIVITGSKDNTCRIWR 415 Score = 106 bits (265), Expect = 2e-23, Method: Composition-based stats. Identities = 27/160 (16%), Positives = 63/160 (39%), Gaps = 7/160 (4%) Query: 452 SCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFS-NNGAFLVATD 510 + VAL+ G D ++ + H + ++AF+ G + Sbjct: 96 TNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLE-GHRNVVYAIAFNNPYGDKIATGS 154 Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 + +SV ++ HTA++ C+S++P + +ATGS+D + +W++ + Sbjct: 155 FDKTCKLWSVETGKCYH---TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEE 211 Query: 571 HPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNVP 610 + H+ ++ + I++ D + W+ Sbjct: 212 VYTL--RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDAD 249 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 19/114 (16%), Positives = 40/114 (35%), Gaps = 13/114 (11%) Query: 506 LVATDQSRKVIPYSVANNFELAHTNSWTF--------HTAKVACVSWSPDNVRLATGSLD 557 L+ ++ +V +L ++ TF H + V+ + TGS D Sbjct: 54 LLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYD 113 Query: 558 NSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT--IVSAGQDSNIKFWNV 609 + +W+ + + + V ++ + N I + D K W+V Sbjct: 114 RTCKLWDTASGEELNTL---EGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV 164 >6QX9-5O nrPDB Length = 357 Score = 217 bits (553), Expect = 9e-57, Method: Composition-based stats. Identities = 60/308 (19%), Positives = 118/308 (38%), Gaps = 18/308 (5%) Query: 54 IYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS 113 + + H + K P+G AS + +W+ T+ SG V ++ +++ Sbjct: 61 LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNY-ATLKGHSGAVMELHYNT 119 Query: 114 ESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVA 173 + + + + V+ +TG L G +NS P + +GSDD TV Sbjct: 120 DGSMLFSASTDK--TVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVK 177 Query: 174 IFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSL 233 +++ TF +T V +V +N S G D I +++ T Sbjct: 178 LWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR---- 232 Query: 234 KNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKV-EKTIPVGTRIEDQ------ 286 H+ SV GL+ S +G+ + S + D T+++W+V E+ + + Sbjct: 233 ---GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLL 289 Query: 287 QLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEG 346 + + + SA+ F+ + I GH +I ++ D + SA ++ Sbjct: 290 RCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDK 349 Query: 347 HINSWDIS 354 + +I Sbjct: 350 RLYMGEIQ 357 Score = 188 bits (477), Expect = 6e-48, Method: Composition-based stats. Identities = 70/347 (20%), Positives = 119/347 (34%), Gaps = 55/347 (15%) Query: 267 NVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSID--QVRYGHN 324 ++L+ + G E L S + I N G D GH+ Sbjct: 51 RCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV-YGDCDNYATLKGHS 109 Query: 325 KAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTV 384 A+ L + DG LFSA + + WD TG + H + + +G Sbjct: 110 GAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKG-HTSFVNSCYPARRGPQLVC 168 Query: 385 SWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTE 444 + D DG + + K AI + Sbjct: 169 TGSD---------------------------------DGTVKLWDIRKKAAIQTFQN--- 192 Query: 445 VPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGA 504 +Y V ++ + GG D+ + V+ L ++ H +T ++ S+ G+ Sbjct: 193 ---TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTM-RGHADSVTGLSLSSEGS 248 Query: 505 FLVATDQSRKVIPYSVA------NNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDN 558 +L++ V + V ++ N F + C SWSPD ++A GS D Sbjct: 249 YLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRC-SWSPDGSKIAAGSADR 307 Query: 559 SVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW-LNETTIVSAGQDSNI 604 V VW+ + I+ K S+N V + +E I+SA D + Sbjct: 308 FVYVWDT---TSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 63/336 (18%), Positives = 117/336 (34%), Gaps = 40/336 (11%) Query: 186 FGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGL 245 H V+ +++P+GS AS G D I+L+N D+ HSG+V L Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD------CDNYATLKGHSGAVMEL 115 Query: 246 TWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGF 305 ++ DG+ + SAS DKT+ +W+ T + K + T + Q + + S +G Sbjct: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175 Query: 306 INFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDV 365 + + + Q + A++ + + S + I WD+ Sbjct: 176 VKLWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRG- 233 Query: 366 HATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDI 425 HA +TG+ +S+G + D+ V + V Sbjct: 234 HADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCV------------------- 274 Query: 426 AVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEV 485 I+ N + S D +A G D V+V+ + + Sbjct: 275 ---------KIFQGNV---HNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILY- 321 Query: 486 KTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVA 521 K H I VAF + +++ +++ + Sbjct: 322 KLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357 Score = 116 bits (291), Expect = 2e-26, Method: Composition-based stats. Identities = 44/296 (14%), Positives = 96/296 (32%), Gaps = 49/296 (16%) Query: 319 VRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSK 378 + GH + +G TL SA + I W++ N H+ + + + Sbjct: 61 LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD 120 Query: 379 GDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYS 438 G + + D V +G V H + + Sbjct: 121 GSMLFSASTDKTVAVWDSETGE-------------------------RVKRLKGHTSFVN 155 Query: 439 HGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVA 498 SC Q V G D V ++ + + ++T + ++ +V Sbjct: 156 -------------SCYPARRGPQLVCTGSDDGTVKLWDIR--KKAAIQTFQNTYQVLAVT 200 Query: 499 FSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDN 558 F++ +++ + + + N T + H V +S S + L + ++DN Sbjct: 201 FNDTSDQIISGGIDNDIKVWDLRQN---KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDN 257 Query: 559 SVIVWNMN--KPSDHPIIIKGAH----AMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 +V VW++ P + + I + + + + + I + D + W+ Sbjct: 258 TVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWD 313 Score = 106 bits (264), Expect = 3e-23, Method: Composition-based stats. Identities = 28/165 (16%), Positives = 58/165 (35%), Gaps = 7/165 (4%) Query: 446 PISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAF 505 C + +A G D + ++ + G + H + + ++ +G+ Sbjct: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123 Query: 506 LVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVA-CVSWSPDNVRLATGSLDNSVIVWN 564 L + + V + HT+ V C + TGS D +V +W+ Sbjct: 124 LFSASTDKTVAVWDSETG---ERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180 Query: 565 MNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 + K + I + + I+S G D++IK W++ Sbjct: 181 IRKKA---AIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDL 222 Score = 61.8 bits (148), Expect = 9e-10, Method: Composition-based stats. Identities = 15/80 (18%), Positives = 33/80 (41%), Gaps = 1/80 (1%) Query: 529 TNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVI 588 + H +V C + P+ LA+ D +++WN+ D+ H+ + + Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDN-YATLKGHSGAVMELHY 117 Query: 589 WLNETTIVSAGQDSNIKFWN 608 + + + SA D + W+ Sbjct: 118 NTDGSMLFSASTDKTVAVWD 137 >3FM0-A nrPDB Length = 345 Score = 217 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 69/330 (20%), Positives = 115/330 (34%), Gaps = 28/330 (8%) Query: 9 LFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYT-----EHSHQTT 63 L +P L PAG + C G + G+ D+ I H Sbjct: 7 LLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRI-WGTEGDSWICKSVLSEGHQRTVR 65 Query: 64 VAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGE 123 SP G Y AS IW Q TT+ VK ++W +A Sbjct: 66 KVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSR 125 Query: 124 GRERF-GHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF--EGPPF 180 + + V D L + + V + PS+ + S S D+TV ++ E + Sbjct: 126 DKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQEL-LASASYDDTVKLYREEEDDW 184 Query: 181 KFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN-GVDGTKTGVF---EDDSLKNV 236 +T H V S+ ++P G AS D T+ ++ + G + GV D S K + Sbjct: 185 VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244 Query: 237 A-----HSGSVFGLTWSPDGTKIASASADKTIKIW------NVATLKVEKTIPVGTRIED 285 HS +++ + W +A+A D I+++ + T + Sbjct: 245 CTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQ 304 Query: 286 QQLGIIWTKQ---ALVSISANGFINFVNPE 312 + W + L S S +G + F + Sbjct: 305 DVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334 Score = 156 bits (393), Expect = 4e-38, Method: Composition-based stats. Identities = 64/361 (17%), Positives = 111/361 (30%), Gaps = 44/361 (12%) Query: 135 DTGTSNGNLTGQ-ARAMNSVDFKPSRPFRIISGSDDNTVAIF--EGPPFKFKSTF-GEHT 190 D+ G + + + P+ + S D + I+ EG + KS H Sbjct: 3 DSLVLLGRVPAHPDSRCWFLAWNPAGTL-LASCGGDRRIRIWGTEGDSWICKSVLSEGHQ 61 Query: 191 KFVHSVRYNPDGSLFASTGGDGTIVLY--NGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 + V V ++P G+ AS D T ++ N D E H V + W+ Sbjct: 62 RTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLE-------GHENEVKSVAWA 114 Query: 249 PDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW--TKQALVSISANGFI 306 P G +A+ S DK++ +W V + + V ++W +++ L S S + + Sbjct: 115 PSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTV 174 Query: 307 NFVNPELGS--IDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPD 364 E GH + +L+ G+ L S + + W + P Sbjct: 175 KLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWR-------QYLPG 227 Query: 365 VHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGD 424 S D SG S LA + D Sbjct: 228 NEQG-------------VACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDD 274 Query: 425 IAVA-----ACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQ-FVAVGGQDSKVHVYKLS 478 +S S + +CVA + + +A D +V +K Sbjct: 275 AIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334 Query: 479 G 479 Sbjct: 335 R 335 Score = 126 bits (315), Expect = 4e-29, Method: Composition-based stats. Identities = 58/350 (16%), Positives = 109/350 (31%), Gaps = 47/350 (13%) Query: 190 TKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP 249 + +NP G+L AS GGD I ++ GT+ + S+ + H +V + WSP Sbjct: 16 DSRCWFLAWNPAGTLLASCGGDRRIRIW----GTEGDSWICKSVLSEGHQRTVRKVAWSP 71 Query: 250 DGTKIASASADKTIKIW--NVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFIN 307 G +ASAS D T IW N + T+ G E + + + L + S + + Sbjct: 72 CGNYLASASFDATTCIWKKNQDDFECVTTLE-GHENEVKSVAWAPSGNLLATCSRDKSVW 130 Query: 308 FVNPELG---SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG--ISNRVF 362 + V H + + + + L SA + + + + Sbjct: 131 VWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATL 190 Query: 363 PDVHATMITGIKTTSKGDLFTVSWDDH-LKVVPAGGSGVDSSKAVANKLSSQPLGLAVSA 421 H + + + G DD +++ G + A + S +S Sbjct: 191 EG-HESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSG 249 Query: 422 DGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGAS 481 + IY +A D + V++ S Sbjct: 250 ---------FHSRTIYDIAWCQLTGA---------------LATACGDDAIRVFQEDPNS 285 Query: 482 VSEVKTI--------VHPAEITSVAFSNNGA-FLVATDQSRKVIPYSVAN 522 + T H ++ VA++ L + +V + Sbjct: 286 DPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQR 335 Score = 118 bits (296), Expect = 5e-27, Method: Composition-based stats. Identities = 53/365 (14%), Positives = 104/365 (28%), Gaps = 68/365 (18%) Query: 234 KNVAHSGSV-FGLTWSPDGTKIASASADKTIKIWNV--ATLKVEKTIPVGTRIEDQQLGI 290 + AH S + L W+P GT +AS D+ I+IW + + + G + +++ Sbjct: 10 RVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAW 69 Query: 291 IWTKQALVSISANGFINFV--NPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHI 348 L S S + N + GH + +++ + G L + + + Sbjct: 70 SPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSV 129 Query: 349 NSWDI--STGISNRVFPDVHATMITGIKTTSKGDLF-TVSWDDHLKVVPAGGSGVDSSKA 405 W++ + H + + +L + S+DD +K+ Sbjct: 130 WVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYRE---------- 179 Query: 406 VANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAV 465 + +G +A Q +A Sbjct: 180 -----EEDDWVCCATLEGH-----------------------ESTVWSLAFDPSGQRLAS 211 Query: 466 GGQDSKVHVYKL---------------SGASVSEVKTIVHPAEITSVAFSNNGAFLVATD 510 D V +++ + H I +A+ L Sbjct: 212 CSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATAC 271 Query: 511 QSRKVIPY------SVANNFELAHTNSWTFHTAKVACVSWSPDNV-RLATGSLDNSVIVW 563 + + + H+ V CV+W+P LA+ S D V W Sbjct: 272 GDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFW 331 Query: 564 NMNKP 568 +P Sbjct: 332 KYQRP 336 Score = 115 bits (287), Expect = 6e-26, Method: Composition-based stats. Identities = 39/215 (18%), Positives = 69/215 (32%), Gaps = 50/215 (23%) Query: 442 LTEVPISYNSSC--VALSNDKQFVAVGGQDSKVHVYKLSGAS--VSEVKTIVHPAEITSV 497 L VP +S C +A + +A G D ++ ++ G S V + H + V Sbjct: 8 LGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKV 67 Query: 498 AFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLD 557 A+S G +L + + N + + H +V V+W+P LAT S D Sbjct: 68 AWSPCGNYLASASFDATTCIWK-KNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRD 126 Query: 558 NSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW---------------------------- 589 SV VW +++ ++ + V V+W Sbjct: 127 KSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVC 186 Query: 590 -----------------LNETTIVSAGQDSNIKFW 607 + + S D ++ W Sbjct: 187 CATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221 Score = 112 bits (280), Expect = 4e-25, Method: Composition-based stats. Identities = 46/325 (14%), Positives = 99/325 (30%), Gaps = 32/325 (9%) Query: 316 IDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGI--SNRVFPDVHATMITGI 373 + +V + L+ + G L S + I W V + H + + Sbjct: 8 LGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKV 67 Query: 374 KTTSKGDLF-TVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYK 432 + G+ + S+D + + + + + +A + K Sbjct: 68 AWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDK 127 Query: 433 HIAIYSHGKLTEVPI-------SYNSSCVALSNDKQFVAVGGQDSKVHVY-KLSGASVSE 484 + ++ + E + + V ++ +A D V +Y + V Sbjct: 128 SVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCC 187 Query: 485 VKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPY-----SVANNFELAHT--------NS 531 H + + S+AF +G L + R V + + + Sbjct: 188 ATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTL 247 Query: 532 WTFHTAKVACVSWSPDNVRLATGSLDNSVIVW------NMNKPSDHPIIIKGAHAMSSVN 585 FH+ + ++W LAT D+++ V+ + +P+ VN Sbjct: 248 SGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVN 307 Query: 586 SVIWLNET--TIVSAGQDSNIKFWN 608 V W + + S D + FW Sbjct: 308 CVAWNPKEPGLLASCSDDGEVAFWK 332 Score = 79.9 bits (195), Expect = 3e-15, Method: Composition-based stats. Identities = 26/136 (19%), Positives = 51/136 (37%), Gaps = 3/136 (2%) Query: 477 LSGASVSEVKTIVHPA-EITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFH 535 + + V + HP +A++ G L + R++ + + + + H Sbjct: 1 MKDSLVLLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGH 60 Query: 536 TAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW-LNETT 594 V V+WSP LA+ S D + +W D + + V SV W + Sbjct: 61 QRTVRKVAWSPCGNYLASASFDATTCIWK-KNQDDFECVTTLEGHENEVKSVAWAPSGNL 119 Query: 595 IVSAGQDSNIKFWNVP 610 + + +D ++ W V Sbjct: 120 LATCSRDKSVWVWEVD 135 >6MZM-G nrPDB Length = 800 Score = 214 bits (544), Expect = 1e-55, Method: Composition-based stats. Identities = 61/292 (20%), Positives = 104/292 (35%), Gaps = 31/292 (10%) Query: 53 EIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWD 112 +I HS A SP Y S G VR+W T ++ + PV D + Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG--YKGHNYPVWDTQFS 594 Query: 113 SESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTV 172 V G +R ++ D G +N F P+ + + +GS D TV Sbjct: 595 PYGYYF--VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY-VATGSADRTV 651 Query: 173 AIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDS 232 +++ F H +HS+ ++P+G A+ DG ++L++ G G + Sbjct: 652 RLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELK--- 708 Query: 233 LKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW 292 H+ +V L +S DG +AS S D T+++W+ I +E Sbjct: 709 ----GHTDTVCSLRFSRDGEILASGSMDNTVRLWD--------AIKAFEDLETDDFT--- 753 Query: 293 TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADA 344 +A G IN + + + L + L + Sbjct: 754 --------TATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVLAAGAY 797 Score = 182 bits (462), Expect = 3e-46, Method: Composition-based stats. Identities = 64/350 (18%), Positives = 111/350 (31%), Gaps = 66/350 (18%) Query: 241 SVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSI 300 + + + D + IA AD T+++ Sbjct: 472 GLTAVDVTDDSSLIAGGFADSTVRV------------XXXXXXXXXXXXXXXXXXXXXXX 519 Query: 301 SANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNR 360 ++ YGH+ + S S D L S+ +G + W + T Sbjct: 520 XXXXXXXXXXXXXXXXXKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCL- 578 Query: 361 VFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVS 420 KG + V WD P G Sbjct: 579 --------------VGYKGHNYPV-WDTQ----------------------FSPYGYYFV 601 Query: 421 ADGDIAVAACY-----KHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVY 475 + G VA + + + I++ G L +V +C + +VA G D V ++ Sbjct: 602 SGGHDRVARLWATDHYQPLRIFA-GHLADV------NCTRFHPNSNYVATGSADRTVRLW 654 Query: 476 KLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFH 535 + + + T H I S+ FS NG FL +V+ + + + + H Sbjct: 655 DVLNGNCVRIFT-GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVG---ELKGH 710 Query: 536 TAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVN 585 T V + +S D LA+GS+DN+V +W+ K + A +N Sbjct: 711 TDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHIN 760 Score = 163 bits (413), Expect = 2e-40, Method: Composition-based stats. Identities = 38/222 (17%), Positives = 84/222 (37%), Gaps = 9/222 (4%) Query: 184 STFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVF 243 H+ V+ ++PD + S+ DGT+ L++ T ++ H+ V+ Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYK-------GHNYPVW 589 Query: 244 GLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISAN 303 +SP G S D+ ++W + + I G + + + SA+ Sbjct: 590 DTQFSPYGYYFVSGGHDRVARLWATDHYQPLR-IFAGHLADVNCTRFHPNSNYVATGSAD 648 Query: 304 GFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFP 363 + + G+ ++ GH I +L+ S +G+ L + +G + WDI G+ Sbjct: 649 RTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELK 708 Query: 364 DVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKA 405 H + ++ + G++ D+ + + + Sbjct: 709 G-HTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET 749 Score = 128 bits (321), Expect = 6e-30, Method: Composition-based stats. Identities = 39/285 (13%), Positives = 87/285 (30%), Gaps = 17/285 (5%) Query: 325 KAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTV 384 + +TA+ + D + A+ + Sbjct: 471 QGLTAVDVTDDSSLIAGGFADSTVRVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 530 Query: 385 SWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKL-T 443 K++ V + ++ L+ S DG + + ++ + L Sbjct: 531 XXXXXXKILYGHSGPVYGASFSPDR----NYLLSSSEDGTVRL------WSLQTFTCLVG 580 Query: 444 EVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNG 503 +Y S + GG D ++ + H A++ F N Sbjct: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIF-AGHLADVNCTRFHPNS 639 Query: 504 AFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVW 563 ++ R V + V N +T H + +++SP+ LATG+ D V++W Sbjct: 640 NYVATGSADRTVRLWDVLNG---NCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLW 696 Query: 564 NMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 ++ + + S+ + + S D+ ++ W+ Sbjct: 697 DIGHGLMVGELKGHTDTVCSLRF--SRDGEILASGSMDNTVRLWD 739 Score = 115 bits (288), Expect = 5e-26, Method: Composition-based stats. Identities = 30/165 (18%), Positives = 60/165 (36%), Gaps = 6/165 (3%) Query: 445 VPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGA 504 S + S D+ ++ +D V ++ L + H + FS G Sbjct: 540 YGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYK-GHNYPVWDTQFSPYGY 598 Query: 505 FLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWN 564 + V+ R ++ + L + H A V C + P++ +ATGS D +V +W+ Sbjct: 599 YFVSGGHDRVARLWATDHYQPL---RIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655 Query: 565 MNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 + + I H + N + + D + W++ Sbjct: 656 VLNGNCVRIFT--GHKGPIHSLTFSPNGRFLATGATDGRVLLWDI 698 Score = 57.6 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 23/123 (18%), Positives = 39/123 (31%), Gaps = 3/123 (2%) Query: 24 LGNTPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGN 82 L +P G + + +G H+ + S G ASG + Sbjct: 675 LTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNT 734 Query: 83 VRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGN 142 VR+WD + L+T F+ I+ S+ + + V L T + Sbjct: 735 VRLWDAIKAFEDLET--DDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVL 792 Query: 143 LTG 145 G Sbjct: 793 AAG 795 Score = 34.5 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 5/35 (14%), Positives = 16/35 (45%) Query: 575 IKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 I H+ + + ++S+ +D ++ W++ Sbjct: 538 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 572 >6F3T-A nrPDB Length = 608 Score = 212 bits (538), Expect = 5e-55, Method: Composition-based stats. Identities = 53/220 (24%), Positives = 92/220 (41%), Gaps = 12/220 (5%) Query: 48 SLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVK 107 + ++ +I HS A SP Y S G VR+W T ++ + PV Sbjct: 340 TASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG--YKGHNYPVW 397 Query: 108 DISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGS 167 D + V G +R ++ D G +N F P+ + + +GS Sbjct: 398 DTQFSPYGYYF--VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY-VATGS 454 Query: 168 DDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGV 227 D TV +++ F H +HS+ ++P+G A+ DG ++L++ G G Sbjct: 455 ADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGE 514 Query: 228 FEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 + H+ +V L +S DG +AS S D T+++W+ Sbjct: 515 LK-------GHTDTVCSLRFSRDGEILASGSMDNTVRLWD 547 Score = 211 bits (537), Expect = 7e-55, Method: Composition-based stats. Identities = 64/347 (18%), Positives = 119/347 (34%), Gaps = 36/347 (10%) Query: 63 TVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVG 122 T + A G VR+W T ++ + S+ I Sbjct: 282 TAVDVTDDSSLIAGGFADSTVRVWSVTPKK-------------LRSVKQASDLSLIDKES 328 Query: 123 EGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKF 182 + + T + L G + + F P R + ++S S+D TV ++ F Sbjct: 329 DD--VLERIMDEKTASELKILYGHSGPVYGASFSPDRNY-LLSSSEDGTVRLWSLQTFTC 385 Query: 183 KSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSV 242 + H V +++P G F S G D L+ +F H V Sbjct: 386 LVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIF-------AGHLADV 438 Query: 243 FGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISA 302 + P+ +A+ SAD+T+++W+V + I G + L + L + + Sbjct: 439 NCTRFHPNSNYVATGSADRTVRLWDVLNGNCVR-IFTGHKGPIHSLTFSPNGRFLATGAT 497 Query: 303 NGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW----------- 351 +G + + G + GH + +L S DG+ L S + + W Sbjct: 498 DGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET 557 Query: 352 -DISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGG 397 D +T + P+ ++ G T + + + V+ AG Sbjct: 558 DDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVLAAGA 604 Score = 198 bits (504), Expect = 4e-51, Method: Composition-based stats. Identities = 69/350 (19%), Positives = 123/350 (35%), Gaps = 66/350 (18%) Query: 241 SVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSI 300 + + + D + IA AD T+++W+V K+ + Sbjct: 280 GLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQAS------------DLSLIDKE 327 Query: 301 SANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNR 360 S + ++ + S ++ YGH+ + S S D L S+ +G + W + T Sbjct: 328 SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCL- 386 Query: 361 VFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVS 420 KG + V WD P G Sbjct: 387 --------------VGYKGHNYPV-WDTQ----------------------FSPYGYYFV 409 Query: 421 ADGDIAVAACY-----KHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVY 475 + G VA + + + I++ G L +V +C + +VA G D V ++ Sbjct: 410 SGGHDRVARLWATDHYQPLRIFA-GHLADV------NCTRFHPNSNYVATGSADRTVRLW 462 Query: 476 KLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFH 535 + + + T H I S+ FS NG FL +V+ + + + + H Sbjct: 463 DVLNGNCVRIFT-GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVG---ELKGH 518 Query: 536 TAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVN 585 T V + +S D LA+GS+DN+V +W+ K + A +N Sbjct: 519 TDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHIN 568 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 47/299 (15%), Positives = 99/299 (33%), Gaps = 41/299 (13%) Query: 138 TSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKF--------------- 182 + + +VD I G D+TV ++ P K Sbjct: 269 ICFYTFLNAYQGLTAVDV-TDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKE 327 Query: 183 ----------------KSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTG 226 H+ V+ ++PD + S+ DGT+ L++ T Sbjct: 328 SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLV 387 Query: 227 VFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQ 286 ++ H+ V+ +SP G S D+ ++W + + I G + Sbjct: 388 GYK-------GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR-IFAGHLADVN 439 Query: 287 QLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEG 346 + + SA+ + + G+ ++ GH I +L+ S +G+ L + +G Sbjct: 440 CTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDG 499 Query: 347 HINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKA 405 + WDI G+ H + ++ + G++ D+ + + + Sbjct: 500 RVLLWDIGHGLMVGELKG-HTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET 557 Score = 141 bits (355), Expect = 8e-34, Method: Composition-based stats. Identities = 49/325 (15%), Positives = 93/325 (28%), Gaps = 65/325 (20%) Query: 176 EGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKN 235 + P TF + + +V D SL A D T+ +++ V + L Sbjct: 264 DCLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSL 323 Query: 236 V------------------------AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATL 271 + HSG V+G ++SPD + S+S D T+++W++ T Sbjct: 324 IDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTF 383 Query: 272 KVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALS 331 VS + + ++ GH + Sbjct: 384 TCLVGYKGHNYPVWDT-QFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTR 442 Query: 332 SSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLK 391 + + + A+ + WD+ G R+F H I + + G D Sbjct: 443 FHPNSNYVATGSADRTVRLWDVLNGNCVRIFTG-HKGPIHSLTFSPNGRFLATGATDGRV 501 Query: 392 VVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNS 451 ++ G G+ + G + Sbjct: 502 LLWDIGHGL----------------MVGELKGHTDTVCSLR------------------- 526 Query: 452 SCVALSNDKQFVAVGGQDSKVHVYK 476 S D + +A G D+ V ++ Sbjct: 527 ----FSRDGEILASGSMDNTVRLWD 547 Score = 141 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 44/289 (15%), Positives = 98/289 (33%), Gaps = 25/289 (8%) Query: 325 KAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTV 384 + +TA+ + D + A+ + W ++ + +K S L Sbjct: 279 QGLTAVDVTDDSSLIAGGFADSTVRVWSVTP------------KKLRSVKQASDLSLIDK 326 Query: 385 SWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVA----ACYKHIAIYSHG 440 DD L+ + + + + S G + S D + ++ + ++ + Sbjct: 327 ESDDVLERIMDEKTASELKILYGH--SGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFT 384 Query: 441 KL-TEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAF 499 L +Y S + GG D ++ + H A++ F Sbjct: 385 CLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIF-AGHLADVNCTRF 443 Query: 500 SNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNS 559 N ++ R V + V N +T H + +++SP+ LATG+ D Sbjct: 444 HPNSNYVATGSADRTVRLWDVLNG---NCVRIFTGHKGPIHSLTFSPNGRFLATGATDGR 500 Query: 560 VIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 V++W++ + + S+ + + S D+ ++ W+ Sbjct: 501 VLLWDIGHGLMVGELKGHTDTVCSLRF--SRDGEILASGSMDNTVRLWD 547 Score = 56.4 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 23/123 (18%), Positives = 39/123 (31%), Gaps = 3/123 (2%) Query: 24 LGNTPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGN 82 L +P G + + +G H+ + S G ASG + Sbjct: 483 LTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNT 542 Query: 83 VRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGN 142 VR+WD + L+T F+ I+ S+ + + V L T + Sbjct: 543 VRLWDAIKAFEDLET--DDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVL 600 Query: 143 LTG 145 G Sbjct: 601 AAG 603 >5WYK-BB nrPDB Length = 943 Score = 209 bits (531), Expect = 3e-54, Method: Composition-based stats. Identities = 79/526 (15%), Positives = 174/526 (33%), Gaps = 92/526 (17%) Query: 163 IISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDG 222 + G D + +++ F H + ++++ G+ S D I++++ V Sbjct: 94 LAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGE 153 Query: 223 TKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTR 282 +H S+ G W + S S D IK+W++ T + +T T Sbjct: 154 VGLYKLR-------SHKDSITGF-WCQGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTG 205 Query: 283 IEDQQLGIIWTKQALVSISANGFINFV--NPELGSIDQVR--------YGHNKAITA--L 330 + G+ L++ + + + E + + + + Sbjct: 206 ---ECWGLAVKDDLLITTGTDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQRGLKIEFI 262 Query: 331 SSSADG-KTLFSADAEGHINSWDISTGISNRVFPDVH----------------------- 366 ++S+D + +A+ I ++ I Sbjct: 263 TNSSDKTSFFYIQNADKTIETFRIRKEEEIARGLKKREKRLKEKGLTEEEIAKSIKESYS 322 Query: 367 ----------------ATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKL 410 + ++SK +L + + ++ D + K Sbjct: 323 SFILHPFQTIRSLYKIKSASWTTVSSSKLELVLTTSSNTIEYYSIPYEKRDPTSPAPLKT 382 Query: 411 SSQPL--------GLAVSADGDIAVAACYKHIAIY---SHGKLTEVPISYNSSCVALSND 459 + L + +S D + A + I+ +H + Y +C Sbjct: 383 HTIELQGQRTDVRSIDISDDNKLLATASNGSLKIWNIKTHKCIRTFECGYALTC-KFLPG 441 Query: 460 KQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYS 519 V +G ++ ++ ++ L+ +S+ + H A I S+ +++G LV + V + Sbjct: 442 GLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWD 501 Query: 520 VANN--------------FELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM 565 +L H + T + CV SPD+ LA LDN+V V+ + Sbjct: 502 FKVENSLVPGTKNKFLPVLKLHHDTTLEL-TDDILCVRVSPDDRYLAISLLDNTVKVFFL 560 Query: 566 NKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNVPF 611 + + + H + ++ I + I+++ D NIK W + F Sbjct: 561 DSMKFYLSLY--GHKLPVLSIDISFDSKMIITSSADKNIKIWGLDF 604 Score = 192 bits (488), Expect = 3e-49, Method: Composition-based stats. Identities = 86/465 (18%), Positives = 150/465 (32%), Gaps = 57/465 (12%) Query: 22 VVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHG 81 V+ ++ + T P T T S A+ +G Sbjct: 354 VLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRTDVRSIDISDDNKLLATAS-NG 412 Query: 82 NVRIWDTTQTTHILKTTIPVFS-GPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSN 140 +++IW+ I F G + + +G L + + Sbjct: 413 SLKIWNIKT-----HKCIRTFECGYALTCKFLPGG-LLVILGTRNGELQLFDLASSSLLD 466 Query: 141 GNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFE---------GPPFKFKSTFGEH-- 189 A+ S+D S R+++GS D TV ++ G KF H Sbjct: 467 TIEDAHDAAIWSLDL-TSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHD 525 Query: 190 -----TKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFG 244 T + VR +PD A + D T+ ++ L H V Sbjct: 526 TTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLDSMKFY-------LSLYGHKLPVLS 578 Query: 245 LTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANG 304 + S D I ++SADK IKIW + K++ + S S + Sbjct: 579 IDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVK-FLPQSHNFFSCSKDA 637 Query: 305 FINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGI------- 357 + + + E Q Y H + AL+ + DG + S+ + I W+ + Sbjct: 638 VVKYWDGEKFECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEETEDQVFLEEEK 697 Query: 358 SNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANK--LSSQPL 415 + T++T ++ + D F A G GV+ + +K L S Sbjct: 698 EKELEEQYEDTLLTSLEEGNGDDAFKAD---------ASGEGVEDEASGVHKQTLESLKA 748 Query: 416 GLAVSADGDIAVA------ACYKHIAIYSHGKLTEVPISYNSSCV 454 G + D+ +A A + + ++ KL E PI + V Sbjct: 749 GERLMEALDLGIAEIEGLEAYNRDMKLWQRKKLGEAPIKPQGNAV 793 Score = 180 bits (456), Expect = 2e-45, Method: Composition-based stats. Identities = 86/613 (14%), Positives = 186/613 (30%), Gaps = 87/613 (14%) Query: 68 SPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRER 127 A G G +++WD T +L + + +D R+ + ++ Sbjct: 88 HKDTDLLAVGYADGVIKVWDLMSKTVLLN--FNGHKAAITLLQFDGTGTRLISGS--KDS 143 Query: 128 FGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFG 187 V+ L ++ F +IS S D + +++ + T Sbjct: 144 NIIVWDLVGEVGLYKLRSHKDSITG--FWCQGEDWLISTSKDGMIKLWDLKTHQCIETHI 201 Query: 188 EHTKFVHSVRYNPDGSLFASTGGDGTIVLY--NGVDGTKTGVFEDDSLKNVAHSGSVFGL 245 HT + L +TG D + ++ + + G + + + Sbjct: 202 AHTGECWGLAV--KDDLLITTGTDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQRGLKI 259 Query: 246 TW----SPDGTKIASASADKTIKIWNVA----------------------------TLKV 273 + S + +ADKTI+ + + ++K Sbjct: 260 EFITNSSDKTSFFYIQNADKTIETFRIRKEEEIARGLKKREKRLKEKGLTEEEIAKSIKE 319 Query: 274 EKTIPVGTRIED----------QQLGIIWTKQALVSISANGFINFV-------NPELGSI 316 + + + + +K LV +++ I + +P + Sbjct: 320 SYSSFILHPFQTIRSLYKIKSASWTTVSSSKLELVLTTSSNTIEYYSIPYEKRDPTSPAP 379 Query: 317 DQV----RYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHA----- 367 + G + ++ S D K L +A G + W+I T R F +A Sbjct: 380 LKTHTIELQGQRTDVRSIDISDDNKLLATASN-GSLKIWNIKTHKCIRTFECGYALTCKF 438 Query: 368 --TMITGIKTTSKGDLFTVSW----------DDHLKVVPAGGSGVDSSKAVANKLSSQPL 415 + I T G+L D H + + D + V Sbjct: 439 LPGGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVK 498 Query: 416 GLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVY 475 + + K + + T + ++ + CV +S D +++A+ D+ V V+ Sbjct: 499 FWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVF 558 Query: 476 KLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFH 535 + + H + S+ S + ++ + + + + + S H Sbjct: 559 -FLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFG---DCHKSLFAH 614 Query: 536 TAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTI 595 + V + P + + S D V W+ I AH + + + Sbjct: 615 QDSIMNVKFLPQSHNFFSCSKDAVVKYWD--GEKFECIQKLYAHQSEVWALAVATDGGFV 672 Query: 596 VSAGQDSNIKFWN 608 VS+ D +I+ W Sbjct: 673 VSSSHDHSIRIWE 685 Score = 113 bits (283), Expect = 2e-25, Method: Composition-based stats. Identities = 73/476 (15%), Positives = 136/476 (28%), Gaps = 82/476 (17%) Query: 202 GSLFASTGGDGTIVLYNGVDGTKTGVFEDD-----SLKNVAHSGSVFGLTWSPDGTKIAS 256 G L S D + +++ G D S A L D +A Sbjct: 39 GQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAV 96 Query: 257 ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSI 316 AD IK+W++ + V G + L T L+S S + I + Sbjct: 97 GYADGVIKVWDLMSKTVLLNFN-GHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVG 155 Query: 317 DQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTT 376 H +IT L S +G I WD+ T H G+ Sbjct: 156 LYKLRSHKDSITGF-WCQGEDWLISTSKDGMIKLWDLKTHQCIETHI-AHTGECWGLAVK 213 Query: 377 SKGDLFTVSWDDHLKVVPAGGS----GVDSSKAVANKLSSQPLGLAV-----SADGDIAV 427 L T D +K+ G ++ + S+ GL + S+D Sbjct: 214 DDL-LITTGTDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQRGLKIEFITNSSDKTSFF 272 Query: 428 AACYKHIAIYSHGKLTEVPISYN------------------------------------- 450 I + E I+ Sbjct: 273 YIQNADKTIETFRIRKEEEIARGLKKREKRLKEKGLTEEEIAKSIKESYSSFILHPFQTI 332 Query: 451 --------SSCVALSNDKQFVAVGGQDSKVHVY-----KLSGASVSEVKT-----IVHPA 492 +S +S+ K + + + + Y K S + +KT Sbjct: 333 RSLYKIKSASWTTVSSSKLELVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRT 392 Query: 493 EITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLA 552 ++ S+ S++ L + + +++ H TF + P + + Sbjct: 393 DVRSIDISDDNKLLATAS-NGSLKIWNIKT-----HKCIRTFECGYALTCKFLPGGLLVI 446 Query: 553 TGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 G+ + + ++++ S I A + + + +V+ D +KFW+ Sbjct: 447 LGTRNGELQLFDLASSSLLDTIEDAHDAAIW-SLDLTSDGKRLVTGSADKTVKFWD 501 Score = 87.6 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 28/159 (17%), Positives = 54/159 (33%), Gaps = 9/159 (5%) Query: 452 SCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQ 511 + + D +AVG D + V+ L +V H A IT + F G L++ + Sbjct: 83 TYLEAHKDTDLLAVGYADGVIKVWDLMSKTVLLNFN-GHKAAITLLQFDGTGTRLISGSK 141 Query: 512 SRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDH 571 +I + + H + W L + S D + +W++ Sbjct: 142 DSNIIVWDL---VGEVGLYKLRSHKDSITGF-WCQGEDWLISTSKDGMIKLWDLKTHQCI 197 Query: 572 PIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNVP 610 I + + +++ G DS +K W + Sbjct: 198 ETHIAHTGECWGLAV----KDDLLITTGTDSQVKIWKLD 232 Score = 31.4 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 9/72 (12%), Positives = 20/72 (27%), Gaps = 12/72 (16%) Query: 548 NVRLATGSLDNSVIVWNMNKPSDHPIII----------KGAHAMSSVNSVIWLNETTIVS 597 + + D V +W++ + +GA + + Sbjct: 39 GQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAV 96 Query: 598 AGQDSNIKFWNV 609 D IK W++ Sbjct: 97 GYADGVIKVWDL 108 >6Q8F-A nrPDB Length = 514 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 55/357 (15%), Positives = 119/357 (33%), Gaps = 52/357 (14%) Query: 176 EGPPFKFKSTFGEHTKF-----VHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFED 230 + KF + H KF V R++PDG + DG I ++N G + Sbjct: 196 DVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKY 255 Query: 231 DSLKN-VAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLG 289 + N + +V + +S D +A+ + D IK+W + + + + L Sbjct: 256 QAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLS 315 Query: 290 IIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHIN 349 ++S S + I + G + GH+ + + + DG + SA ++G + Sbjct: 316 FSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVK 375 Query: 350 SWDISTGISNRVFPDVHATMITGIKTT-------SKGDLFTVSWDDHLKVVPAGGSGVDS 402 W++ T + F + +T T I + + + + ++ G V S Sbjct: 376 IWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRS 435 Query: 403 SKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQF 462 + + + C ALS ++ Sbjct: 436 FSSGKRE--------------------------------------GGDFVCCALSPRGEW 457 Query: 463 VAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYS 519 + G+D ++ + + T VH ++ +A + + + + + Sbjct: 458 IYCVGEDFVLYCFSTVTGKLERTLT-VHEKDVIGIAHHPHQNLIATYSEDGLLKLWK 513 Score = 164 bits (415), Expect = 9e-41, Method: Composition-based stats. Identities = 46/305 (15%), Positives = 103/305 (33%), Gaps = 15/305 (4%) Query: 57 EHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSG------PVKDIS 110 A+ SP G Y +G V G + +W+ T V + Sbjct: 213 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 272 Query: 111 WDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLT-GQARAMNSVDFKPSRPFRIISGSDD 169 + +++ +A + + V+ +G ++ + + F +I+S S D Sbjct: 273 FSRDTEMLATGAQDGK--IKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSS-QILSASFD 329 Query: 170 NTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFE 229 T+ I K F H+ FV+ + DG S DGT+ ++N + F+ Sbjct: 330 QTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFK 389 Query: 230 DDSLKNVAHSGSVFGLTWSP-DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQ-- 286 +V + P + + T+ I N+ ++ ++ G R Sbjct: 390 -SLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQ-GQIVRSFSSGKREGGDFV 447 Query: 287 QLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEG 346 + + + + + + + G +++ H K + ++ + + +G Sbjct: 448 CCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDG 507 Query: 347 HINSW 351 + W Sbjct: 508 LLKLW 512 Score = 127 bits (318), Expect = 2e-29, Method: Composition-based stats. Identities = 52/353 (14%), Positives = 105/353 (29%), Gaps = 60/353 (16%) Query: 272 KVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGH-------- 323 ++ + I G + + Q LV+ S +GFI N G I + Sbjct: 205 QLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMM 264 Query: 324 NKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFT 383 + A+ + S D + L + +G I W I +G R F H+ +T + + Sbjct: 265 DDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQI- 323 Query: 384 VSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLT 443 L+ S D I + GK Sbjct: 324 ---------------------------------LSASFDQTIRIHGL-------KSGKTL 343 Query: 444 EVPISYNS--SCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAE-----ITS 496 + ++S + + D ++ D V ++ + S + + S Sbjct: 344 KEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNS 403 Query: 497 VAFSN-NGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGS 555 V N V ++S V+ ++ + ++ V C + SP + Sbjct: 404 VILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCC-ALSPRGEWIYCVG 462 Query: 556 LDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 D + ++ + H + ++ I + +D +K W Sbjct: 463 EDFVLYCFSTVTGKLERTLTV--HEKDVIGIAHHPHQNLIATYSEDGLLKLWK 513 Score = 115 bits (288), Expect = 5e-26, Method: Composition-based stats. Identities = 32/178 (17%), Positives = 68/178 (38%), Gaps = 13/178 (7%) Query: 440 GKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASV-SEVKTIVH------PA 492 + + + C S D Q++ G D + V+ + + ++K Sbjct: 207 SRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDD 266 Query: 493 EITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLA 552 + + FS + L Q K+ + + + L H+ V C+S+S D+ ++ Sbjct: 267 AVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFER--AHSKGVTCLSFSKDSSQIL 324 Query: 553 TGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWL-NETTIVSAGQDSNIKFWNV 609 + S D ++ + + + + S VN + + I+SA D +K WN+ Sbjct: 325 SASFDQTIRIHGLKSG---KTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 379 Score = 101 bits (250), Expect = 1e-21, Method: Composition-based stats. Identities = 40/221 (18%), Positives = 63/221 (28%), Gaps = 23/221 (10%) Query: 56 TEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSES 115 HS T S S +RI + S V + ++ + Sbjct: 305 RAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTL--KEFRGHSSFVNEATFTQDG 362 Query: 116 KRIAAVGEGRERFGHVFLFDTGTSNGNLT------GQARAMNSVDFKPSRPFRIISGSDD 169 I + ++ T + G +NSV P P + + Sbjct: 363 HYIISASSDG--TVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRS 420 Query: 170 NTVAIFEGPPFKFKSTFGEHT----KFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKT 225 NTV I + +F FV +P G G D + ++ V G Sbjct: 421 NTVVIMNM-QGQIVRSFSSGKREGGDFVCC-ALSPRGEWIYCVGEDFVLYCFSTVTGKLE 478 Query: 226 GVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIW 266 H V G+ P IA+ S D +K+W Sbjct: 479 RTL-------TVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 512 Score = 84.9 bits (208), Expect = 8e-17, Method: Composition-based stats. Identities = 24/132 (18%), Positives = 50/132 (37%), Gaps = 6/132 (4%) Query: 480 ASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYS-----VANNFELAHTNSWTF 534 +S + + FS +G +LV + ++ + + + +++ Sbjct: 204 TQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMM 263 Query: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT 594 V C+ +S D LATG+ D + VW + + + AH+ + + Sbjct: 264 MDDAVLCMCFSRDTEMLATGAQDGKIKVWKI-QSGQCLRRFERAHSKGVTCLSFSKDSSQ 322 Query: 595 IVSAGQDSNIKF 606 I+SA D I+ Sbjct: 323 ILSASFDQTIRI 334 Score = 80.7 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 36/177 (20%), Positives = 59/177 (33%), Gaps = 20/177 (11%) Query: 53 EIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWD 112 + + HS A + G+Y S G V+IW+ +TT T + S DI+ + Sbjct: 344 KEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN-MKTTECSNTFKSLGSTAGTDITVN 402 Query: 113 S------ESKRIAAVGEGRERF------GHVFLFDTGTSNGNLTGQARAMNSVDFKPSRP 160 S + V F +G G P Sbjct: 403 SVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREG------GDFVCCALSPRGE 456 Query: 161 FRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLY 217 + G +D + F K + T H K V + ++P +L A+ DG + L+ Sbjct: 457 WIYCVG-EDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 512 >5GAN-H nrPDB Length = 465 Score = 200 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 120/300 (40%), Gaps = 15/300 (5%) Query: 59 SHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSE--SK 116 + + S A+G G++++ + +QT L + G + I W + ++ Sbjct: 175 TKPISAVSLSTDDMVVATGSWAGDLQVLN-SQTLQPLTQKLDSHVGKIGAIDWHPDSNNQ 233 Query: 117 RIAAVGEGRERFGHVFLFDTG-TSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF 175 I+ +G + + G G+L G R ++ V + PS F I S S D T ++ Sbjct: 234 MISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKF-IGSASHDMTWRLW 292 Query: 176 EGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKN 235 + + H K V S+ + DGSL S G D +L++ G+K Sbjct: 293 DASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTL------- 345 Query: 236 VAHSGSVFGLTWSPDGTKIASASADKTIKIWNV---ATLKVEKTIPVGTRIEDQQLGIIW 292 HS ++ + WSP+G ++A+ D I +W++ ++ + + + + Sbjct: 346 AGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKED 405 Query: 293 TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 + LVS + IN + + GH I +L S + L S + I W+ Sbjct: 406 GGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 151 bits (380), Expect = 1e-36, Method: Composition-based stats. Identities = 49/277 (17%), Positives = 101/277 (36%), Gaps = 23/277 (8%) Query: 1 MSEFSQTALFPSLPRTARGTAVVLGNTP-AGDKIQYCNGTSV-----YTVPVGSLTDTEI 54 ++ + L L G + P + +++ C + Y+ G L Sbjct: 202 LNSQTLQPLTQKLDSHV-GKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGD 260 Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSE 114 H + + K PSG + S R+WD + +L V +S+ + Sbjct: 261 LVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQ--EGHDKGVFSLSFQCD 318 Query: 115 SKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAI 174 + G + ++ +G+ L G ++ + +V + P+ +++ +G D + + Sbjct: 319 GSLV--CSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPN-GYQVATGGGDGIINV 375 Query: 175 FEGPPFKF--KSTFGEHTKFVHSVRYNPD--GSLFASTGGDGTIVLYNGVDGTKTGVFED 230 ++ + H V VR++ + G S G D I +Y+ K G Sbjct: 376 WDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSL-- 433 Query: 231 DSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 H+ + L S + + S D++IK+WN Sbjct: 434 -----AGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 142 bits (357), Expect = 5e-34, Method: Composition-based stats. Identities = 59/335 (17%), Positives = 111/335 (33%), Gaps = 49/335 (14%) Query: 147 ARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFK-FKSTFGEHTKFVHSVRYNPDGSL- 204 + +++V + +GS + + + H + ++ ++PD + Sbjct: 175 TKPISAVSLSTDD-MVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQ 233 Query: 205 FASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIK 264 S DG I + + D V H + + + P G I SAS D T + Sbjct: 234 MISCAEDGLIKNFQYSNEEGGLRLLGD---LVGHERRISDVKYHPSGKFIGSASHDMTWR 290 Query: 265 IWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHN 324 +W+ +T + + G L + S + + GS GH+ Sbjct: 291 LWDASTHQELL-LQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHS 349 Query: 325 KAITALSSSADGKTLFSADAEGHINSWDIST---GISNRVFPDVHATMITGIKTTSKGDL 381 K I ++ S +G + + +G IN WDI G N++ H ++T ++ + + Sbjct: 350 KPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQIL--AHRNIVTQVRFSKE--- 404 Query: 382 FTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGK 441 D K+V G + N SS S G Sbjct: 405 -----DGGKKLVSCGYDN------LINVYSSDTWLKMGSLAGHTDKIISLD--------- 444 Query: 442 LTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYK 476 +SN+ F+ GG D + ++ Sbjct: 445 --------------ISNNSHFLVSGGWDRSIKLWN 465 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 52/297 (17%), Positives = 95/297 (31%), Gaps = 18/297 (6%) Query: 324 NKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFT 383 K I+A+S S D + + G + + T D H I I + Sbjct: 175 TKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQM 234 Query: 384 VSWDDHLKVVPAGGSGVDSSKAV----------ANKLSSQPLGLAVSADGDIAVAACYKH 433 +S + + S + + + + P G + + + Sbjct: 235 ISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWD- 293 Query: 434 IAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAE 493 A L + ++ D V GG DS ++ + S H Sbjct: 294 -ASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTL-AGHSKP 351 Query: 494 ITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPD--NVRL 551 I +VA+S NG + + + + + N H V V +S + +L Sbjct: 352 IYTVAWSPNGYQVATGGGDGIINVWDIRKR-DEGQLNQILAHRNIVTQVRFSKEDGGKKL 410 Query: 552 ATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 + DN + V++ + + H ++ I N +VS G D +IK WN Sbjct: 411 VSCGYDNLINVYSSDTWLKMGSLA--GHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 123 bits (307), Expect = 3e-28, Method: Composition-based stats. Identities = 64/334 (19%), Positives = 116/334 (34%), Gaps = 51/334 (15%) Query: 239 SGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA-L 297 + + ++ S D +A+ S +++ N TL+ + + + Sbjct: 175 TKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQM 234 Query: 298 VSISANGFINFVNPELGS----IDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 +S + +G I + GH + I+ + GK + SA + WD Sbjct: 235 ISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDA 294 Query: 354 STGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQ 413 ST + + H + + G L D L ++ SG SK + S+ Sbjct: 295 STHQEL-LLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSG---SKVMTLAGHSK 350 Query: 414 PLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVH 473 P IY+ VA S + VA GG D ++ Sbjct: 351 P---------------------IYT---------------VAWSPNGYQVATGGGDGIIN 374 Query: 474 VYKLSGASVSEV-KTIVHPAEITSVAFSNN--GAFLVATDQSRKVIPYSVANNFELAHTN 530 V+ + ++ + + H +T V FS G LV+ + YS ++ Sbjct: 375 VWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMG--- 431 Query: 531 SWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWN 564 S HT K+ + S ++ L +G D S+ +WN Sbjct: 432 SLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 93.4 bits (230), Expect = 3e-19, Method: Composition-based stats. Identities = 25/161 (15%), Positives = 56/161 (34%), Gaps = 11/161 (6%) Query: 454 VALSNDKQ-FVAVGGQDSKVHVY---KLSGASVSEVKTIVHPAEITSVAFSNNGAFLVAT 509 + D + +D + + G + H I+ V + +G F+ + Sbjct: 224 IDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSA 283 Query: 510 DQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPS 569 + + + EL H V +S+ D + +G +D+ ++W++ S Sbjct: 284 SHDMTWRLWDASTHQELL---LQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGS 340 Query: 570 DHPIIIKGAHAMSSVNSVIWLNETT-IVSAGQDSNIKFWNV 609 + A + +V W + + G D I W++ Sbjct: 341 KVMTL---AGHSKPIYTVAWSPNGYQVATGGGDGIINVWDI 378 >5WLC-LO nrPDB Length = 923 Score = 198 bits (504), Expect = 5e-51, Method: Composition-based stats. Identities = 90/660 (13%), Positives = 208/660 (31%), Gaps = 106/660 (16%) Query: 2 SEFSQTALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQ 61 S+F + L ++ R + + G ++ G V + + EH Sbjct: 3 SDFKFSNLLGTVYRQGN-----ITFSDDGKQLLSPVGNRVSVFDLINNKSFTFEYEHRKN 57 Query: 62 TTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAV 121 + G S D G + F + + + + A Sbjct: 58 IAAIDLNKQGTLLISIDEDGRAIL---VNFKARNVLHHFNFKEKCSAVKFSPDGRLFALA 114 Query: 122 GEGRERFG------HVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF 175 + F + G + + S+ + F I++ S D + I+ Sbjct: 115 SGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRF-ILTTSKDLSAKIW 173 Query: 176 EGPPFK---FKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGV------------ 220 + +TF H +V ++ D + DG + ++ Sbjct: 174 SVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESE 233 Query: 221 --------DGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLK 272 D +K A+ V +T+ P +A +++++ Sbjct: 234 DDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFT 293 Query: 273 VEKTIPVGTRIEDQQLGIIWTKQALVSISAN-GFINFVNPELGSIDQVRYGHNKAITALS 331 + + + +G + + + T + L S+ G + + S + GH + +L+ Sbjct: 294 LIQQLSMGQNPVN-TVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLA 352 Query: 332 SSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLK 391 S DG + +A +G I WDI++G F + H + +T ++ +G + Sbjct: 353 YSPDGSRVVTASEDGKIKVWDITSGFCLATFEE-HTSSVTAVQFAKRGQVM--------- 402 Query: 392 VVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAAC--YKHIAIYSHGKLTEVPISY 449 + S DG + Y++ ++ + + Sbjct: 403 -------------------------FSSSLDGTVRAWDLIRYRNFRTFTGTERIQF---- 433 Query: 450 NSSCVALSNDKQFVAVGGQDS-KVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVA 508 +C+A+ + V G D+ +HV+ + + + + H ++ ++FS + L + Sbjct: 434 --NCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALS-GHEGPVSCLSFSQENSVLAS 490 Query: 509 TDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNK- 567 + + +S+ + + V +S PD +A +L + ++N+ Sbjct: 491 ASWDKTIRIWSIFGRSQQVEPIEVY---SDVLALSMRPDGKEVAVSTLKGQISIFNIEDA 547 Query: 568 -----------------PSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNVP 610 D + + IV+ G +++I ++VP Sbjct: 548 KQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVP 607 Score = 193 bits (489), Expect = 3e-49, Method: Composition-based stats. Identities = 92/534 (17%), Positives = 176/534 (32%), Gaps = 87/534 (16%) Query: 63 TVAKTSPSGYYCASGDVHGNVRIW-------DTTQTTHILKTTIPVFSGPVKDISWDSES 115 + K SP G A ++IW D + + ++W +S Sbjct: 100 SAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDS 158 Query: 116 KRIAAVGEGRERFGHVFLFDTGTSN---GNLTGQARAMNSVDFKPSRPFRIISGSDDNTV 172 + I ++ ++ D+ N G + F + +I + S D V Sbjct: 159 RFILTTS--KDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQE-KIYTVSKDGAV 215 Query: 173 AIFEGP-------------------------PFKF--KSTFGEHTKFVHSVRYNPDGSLF 205 ++E ++ K F + V V ++P L Sbjct: 216 FVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLL 275 Query: 206 ASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASAD-KTIK 264 A G LY+ D T V ++ + G +A S+ + Sbjct: 276 AVGFTSGEFRLYDLPDFTLIQQLSMG-------QNPVNTVSVNQTGEWLAFGSSKLGQLL 328 Query: 265 I--WNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYG 322 + W + +++ G L +V+ S +G I + G Sbjct: 329 VYEWQSESYILKQQ---GHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEE 385 Query: 323 HNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLF 382 H ++TA+ + G+ +FS+ +G + +WD+ + R F + G++ Sbjct: 386 HTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVV 445 Query: 383 TV----SWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACY-KHIAIY 437 ++D H+ V G +D+ +S L+ S + + +A + K I I+ Sbjct: 446 CAGSLDNFDIHVWSVQT-GQLLDALSGHEGPVSC----LSFSQENSVLASASWDKTIRIW 500 Query: 438 S-HGKLTEV-PISYNSSCVALS--NDKQFVAVGGQDSKVHVYKLSGASVS---------- 483 S G+ +V PI S +ALS D + VAV ++ ++ + A Sbjct: 501 SIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDII 560 Query: 484 ---------EVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAH 528 K T++ +S +G +VA + + Y V N L Sbjct: 561 SGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKR 614 Score = 64.1 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 46/301 (15%), Positives = 98/301 (32%), Gaps = 48/301 (15%) Query: 24 LGNTPAGDKIQYCNGTS----VYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDV 79 L P+G+ + + + V++V G L D + H + S AS Sbjct: 436 LAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDA--LSGHEGPVSCLSFSQENSVLASASW 493 Query: 80 HGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTS 139 +RIW I V+S V +S + K +A V + + +F + Sbjct: 494 DKTIRIWSI-FGRSQQVEPIEVYSD-VLALSMRPDGKEVA-VSTLKGQIS-IFNIEDAKQ 549 Query: 140 NGNLTGQARAMNSVDFKPSR--------------------PFRIISGSDDNTVAIFEGPP 179 GN+ + + S F R I++G ++N++ +++ P Sbjct: 550 VGNID-CRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPN 608 Query: 180 FKFKSTF--GEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 F + ++ + + + D ++ + + + D+SL Sbjct: 609 EVLLKRFIVSRNMALNGTLEFLNSKKMTEAGSLD---LIDDAGENSDLEDRIDNSLPGSQ 665 Query: 238 HSGS-----------VFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQ 286 G V + +SP A+AS + + I++ + + + Sbjct: 666 RGGDLSTRKMRPEVRVTSVQFSPTANAFAAASTEGLL-IYSTNDTILFDPFDLDVDVTPH 724 Query: 287 Q 287 Sbjct: 725 S 725 >6QX9-4B nrPDB Length = 522 Score = 196 bits (497), Expect = 3e-50, Method: Composition-based stats. Identities = 50/301 (16%), Positives = 107/301 (35%), Gaps = 16/301 (5%) Query: 57 EHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS--- 113 + SP+ A+ G ++W + T+ + V I + Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLH--TLRGHNTNVGAIVFHPKST 286 Query: 114 ---ESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDN 170 + K + + ++ D+ ++ G + V + PS F + + D Sbjct: 287 VSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRF-LGTTCYDR 345 Query: 171 TVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFED 230 + +++ + H+ V+ + ++ DGSL + G D +++ G E Sbjct: 346 SWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLE- 404 Query: 231 DSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGI 290 H ++G+ +SP+G IA+ S D T K+W++ + TIP + Sbjct: 405 ------GHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFE 458 Query: 291 IWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINS 350 L++ + + S + GH + L S+DG+ + + + Sbjct: 459 PIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKL 518 Query: 351 W 351 W Sbjct: 519 W 519 Score = 162 bits (409), Expect = 4e-40, Method: Composition-based stats. Identities = 48/354 (13%), Positives = 107/354 (30%), Gaps = 60/354 (16%) Query: 132 FLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTK 191 + + + G R ++ F P+ + + ++ P T H Sbjct: 216 KSLRSLNNFCSQIGDDRPISYCHFSPNSKM-LATACWSGLCKLWSVPDCNLLHTLRGHNT 274 Query: 192 FVHSVRYNPDGS--------LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVF 243 V ++ ++P + AS DG++ L++ E H+ V Sbjct: 275 NVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIE-------GHTVRVA 327 Query: 244 GLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISAN 303 + W P G + + D++ ++W++ + E G + + + + Sbjct: 328 RVMWHPSGRFLGTTCYDRSWRLWDLEA-QEEILHQEGHSMGVYDIAFHQDGSLAGTGGLD 386 Query: 304 GFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFP 363 F + G GH K I ++ S +G + + + WD+ P Sbjct: 387 AFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIP 446 Query: 364 DVHATMITGIKTTSKGDLFTV--SWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSA 421 H ++TG+K F + ++D+ K+ G Sbjct: 447 -AHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPG------------------------ 481 Query: 422 DGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVY 475 + + + + +S+D Q +A D ++ Sbjct: 482 ---------WSPLKTLA-------GHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 54/338 (15%), Positives = 104/338 (30%), Gaps = 52/338 (15%) Query: 234 KNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTR-------IEDQ 286 + + +SP+ +A+A K+W+V + T+ Sbjct: 226 SQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKS 285 Query: 287 QLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEG 346 + + L S +A+G + + + GH + + G+ L + + Sbjct: 286 TVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDR 345 Query: 347 HINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAV 406 WD+ + + H+ + I G L AG G+D+ V Sbjct: 346 SWRLWDLE-AQEEILHQEGHSMGVYDIAFHQDGSL-------------AGTGGLDAFGRV 391 Query: 407 ANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVG 466 + L + + + G L E+ + S + +A G Sbjct: 392 WD-LRTGRCIMFL-------------------EGHLKEIY------GINFSPNGYHIATG 425 Query: 467 GQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSN-NGAFLVATDQSRKVIPYSVANNFE 525 D+ V+ L H +T V F +G FL+ + + Sbjct: 426 SGDNTCKVWDLRQRRCVYTI-PAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIW---THPG 481 Query: 526 LAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVW 563 + + H KV + S D +AT S D + +W Sbjct: 482 WSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 133 bits (334), Expect = 3e-31, Method: Composition-based stats. Identities = 48/341 (14%), Positives = 85/341 (24%), Gaps = 55/341 (16%) Query: 276 TIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAI-------- 327 +G + L + +G + ++ GHN + Sbjct: 225 CSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPK 284 Query: 328 TALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWD 387 + +S L S A+G + W + + H + + G + Sbjct: 285 STVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEG-HTVRVARVMWHPSGRFLGTTCY 343 Query: 388 DHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPI 447 D + + + L + Sbjct: 344 DRSWRLWDLEAQEEI---------------------------------------LHQEGH 364 Query: 448 SYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLV 507 S +A D GG D+ V+ L H EI + FS NG + Sbjct: 365 SMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLE-GHLKEIYGINFSPNGYHIA 423 Query: 508 ATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVWNMN 566 + + + H V V + P L TG+ DN+ +W Sbjct: 424 TGSGDNTCKVWDLRQRR---CVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHP 480 Query: 567 KPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFW 607 S + H + I + I + D K W Sbjct: 481 GWSPLKTLA--GHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 44.5 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 9/53 (16%), Positives = 17/53 (32%), Gaps = 2/53 (3%) Query: 34 QYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIW 86 Y N ++T P + + H + S G A+ ++W Sbjct: 469 AYDNTAKIWTHP--GWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 >5I2T-A nrPDB Length = 742 Score = 194 bits (492), Expect = 1e-49, Method: Composition-based stats. Identities = 89/658 (13%), Positives = 205/658 (31%), Gaps = 102/658 (15%) Query: 2 SEFSQTALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQ 61 S+F + L ++ R + + G ++ G V + + EH Sbjct: 28 SDFKFSNLLGTVYRQGN-----ITFSDDGKQLLSPVGNRVSVFDLINNKSFTFEYEHRKN 82 Query: 62 TTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAV 121 + G S D G + F + + + + A Sbjct: 83 IAAIDLNKQGTLLISIDEDGRAIL---VNFKARNVLHHFNFKEKCSAVKFSPDGRLFALA 139 Query: 122 GEGRERFG------HVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF 175 + F + G + + S+ + F I++ S D + I+ Sbjct: 140 SGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRF-ILTTSKDLSAKIW 198 Query: 176 EGPPFK---FKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGV------------ 220 + +TF H +V ++ D + DG + ++ Sbjct: 199 SVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESE 258 Query: 221 --------DGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLK 272 D +K A+ V +T+ P +A +++++ Sbjct: 259 DDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFT 318 Query: 273 VEKTIPVGTRIEDQQLGIIWTKQALVSISAN-GFINFVNPELGSIDQVRYGHNKAITALS 331 + + + +G + + + T + L S+ G + + S + GH + +L+ Sbjct: 319 LIQQLSMGQNPVN-TVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLA 377 Query: 332 SSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLK 391 S DG + +A +G I WDI++G F + H + +T ++ +G + Sbjct: 378 YSPDGSRVVTASEDGKIKVWDITSGFCLATFEE-HTSSVTAVQFAKRGQVM--------- 427 Query: 392 VVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNS 451 + S DG + ++ + + Sbjct: 428 -------------------------FSSSLDGTVRAWDLIRYRNFRTFTGTERI----QF 458 Query: 452 SCVALSNDKQFVAVGGQDS-KVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATD 510 +C+A+ + V G D+ +HV+ + + + + H ++ ++FS + L + Sbjct: 459 NCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALS-GHEGPVSCLSFSQENSVLASAS 517 Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNK--- 567 + + +S+ + + V +S PD +A +L + ++N+ Sbjct: 518 WDKTIRIWSIFGRSQQVEPIEVY---SDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQ 574 Query: 568 ---------------PSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNVP 610 D + + IV+ G +++I ++VP Sbjct: 575 VGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVP 632 Score = 188 bits (477), Expect = 6e-48, Method: Composition-based stats. Identities = 92/534 (17%), Positives = 175/534 (32%), Gaps = 87/534 (16%) Query: 63 TVAKTSPSGYYCASGDVHGNVRIW-------DTTQTTHILKTTIPVFSGPVKDISWDSES 115 + K SP G A ++IW D + + ++W +S Sbjct: 125 SAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDS 183 Query: 116 KRIAAVGEGRERFGHVFLFDTGTSN---GNLTGQARAMNSVDFKPSRPFRIISGSDDNTV 172 + I ++ ++ D+ N G + F + +I + S D V Sbjct: 184 RFILTTS--KDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQE-KIYTVSKDGAV 240 Query: 173 AIFEGP-------------------------PFKF--KSTFGEHTKFVHSVRYNPDGSLF 205 ++E ++ K F + V V ++P L Sbjct: 241 FVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLL 300 Query: 206 ASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKT--- 262 A G LY+ D T V ++ + G +A S+ Sbjct: 301 AVGFTSGEFRLYDLPDFTLIQQLSMG-------QNPVNTVSVNQTGEWLAFGSSKLGQLL 353 Query: 263 IKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYG 322 + W + +++ G L +V+ S +G I + G Sbjct: 354 VYEWQSESYILKQQ---GHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEE 410 Query: 323 HNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLF 382 H ++TA+ + G+ +FS+ +G + +WD+ + R F + G++ Sbjct: 411 HTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVV 470 Query: 383 TV----SWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACY-KHIAIY 437 ++D H+ V G +D+ +S L+ S + + +A + K I I+ Sbjct: 471 CAGSLDNFDIHVWSVQT-GQLLDALSGHEGPVSC----LSFSQENSVLASASWDKTIRIW 525 Query: 438 S-HGKLTEV-PISYNSSCVALS--NDKQFVAVGGQDSKVHVYKLSGASVS---------- 483 S G+ +V PI S +ALS D + VAV ++ ++ + A Sbjct: 526 SIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDII 585 Query: 484 ---------EVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAH 528 K T++ +S +G +VA + + Y V N L Sbjct: 586 SGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKR 639 Score = 61.0 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 45/277 (16%), Positives = 92/277 (33%), Gaps = 47/277 (16%) Query: 24 LGNTPAGDKIQYCNGTS----VYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDV 79 L P+G+ + + + V++V G L D + H + S AS Sbjct: 461 LAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDA--LSGHEGPVSCLSFSQENSVLASASW 518 Query: 80 HGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTS 139 +RIW I V+S V +S + K +A V + + +F + Sbjct: 519 DKTIRIWSI-FGRSQQVEPIEVYSD-VLALSMRPDGKEVA-VSTLKGQIS-IFNIEDAKQ 574 Query: 140 NGNLTGQARAMNSVDFKPSR--------------------PFRIISGSDDNTVAIFEGPP 179 GN+ + + S F R I++G ++N++ +++ P Sbjct: 575 VGNID-CRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPN 633 Query: 180 FKFKSTF--GEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 F + ++ + + + D ++ + + + D+SL Sbjct: 634 EVLLKRFIVSRNMALNGTLEFLNSKKMTEAGSLD---LIDDAGENSDLEDRIDNSLPGSQ 690 Query: 238 HSGS-----------VFGLTWSPDGTKIASASADKTI 263 G V + +SP A+AS + + Sbjct: 691 RGGDLSTRKMRPEVRVTSVQFSPTANAFAAASTEGLL 727 >3MKQ-A nrPDB Length = 814 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 93/517 (17%), Positives = 170/517 (32%), Gaps = 48/517 (9%) Query: 48 SLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVK 107 L + ++ S + P+ + + G V IW+ T + +I V PV+ Sbjct: 2 KLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWN--YETQVEVRSIQVTETPVR 59 Query: 108 DISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGS 167 + + I VG R VF ++TG + + S+ P++P+ + SGS Sbjct: 60 AGKFIARKNWII-VGSDDFRI-RVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVL-SGS 116 Query: 168 DDNTVAIFEG-PPFKFKSTFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKT 225 DD TV ++ + + TF H FV V +NP D S FAS D T+ +++ T Sbjct: 117 DDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPN 176 Query: 226 GVFEDDSLKNVAHSGSVFGLTWS--PDGTKIASASADKTIKIWNVATLKVEKTIPVGTRI 283 V + + PD + +AS D TIKIW+ T T+ Sbjct: 177 FTL------TTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSN 230 Query: 284 EDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGK--TLFS 341 + T ++S S +G + N +++ + +++ G+ + S Sbjct: 231 VSFAV-FHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIAS 289 Query: 342 ADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSW-------DDHLKVVP 394 + + V + +G K + D+FT D + Sbjct: 290 G-FDNGFTVLSLGNDEPTLSLDPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQ 348 Query: 395 AGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCV 454 G + S + V DG+ + + GK + Sbjct: 349 TKELGSVDVFPQSLAHSPNGRFVTVVGDGEYVIYTALA-WRNKAFGKCQDF--------- 398 Query: 455 ALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRK 514 D A+ + ++ YK + V+ +H A L+ Sbjct: 399 VWGPDSNSYALIDETGQIKYYK-NFKEVTSWSVPMHSAIDRLF-----SGALLGVKSDGF 452 Query: 515 VIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRL 551 V + N + + V WS + + Sbjct: 453 VYFFDWDNGTLVRRIDVNA------KDVIWSDNGELV 483 Score = 170 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 89/517 (17%), Positives = 171/517 (33%), Gaps = 53/517 (10%) Query: 95 LKTTIPVFSGPVKDISWDSESKRIAAV-GEGRERFGHVFLFDTGTSNGNLTGQARAMNSV 153 +K T S VK I + + GR ++ ++T ++ + + Sbjct: 5 IKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGR---VEIWNYETQVEVRSIQVTETPVRAG 61 Query: 154 DFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGT 213 F + + II GSDD + +F + F H ++ S+ +P S D T Sbjct: 62 KFIARKNW-IIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLT 120 Query: 214 IVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP-DGTKIASASADKTIKIWNVATLK 272 + L+N + H V + ++P D + AS D+T+K+W++ Sbjct: 121 VKLWNWENNWALE------QTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQST 174 Query: 273 VEKTIPVGTRIEDQQLG--IIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITAL 330 T+ G + + K +++ S + I + + S GH ++ Sbjct: 175 PNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFA 234 Query: 331 SSSADGKTLFSADAEGHINSWDISTGISNRVF-PDVHATMITGIKTTSKGDLFTVSWDDH 389 + S +G + W+ ST + + + T + + +D+ Sbjct: 235 VFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNG 294 Query: 390 LKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACY-----KHIAIYSHGKLTE 444 V+ G S KL A ++D AV +L Sbjct: 295 FTVLSLGNDEPTLSLDPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKELGS 354 Query: 445 VPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGA 504 V + S +A S + +FV V G D + +Y + + + Sbjct: 355 VDVFPQS--LAHSPNGRFVTVVG-DGEYVIYTALAWRNKAF------GKCQDFVWGPDSN 405 Query: 505 FLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGS-----LDNS 559 D++ ++ Y NF+ + S H+A RL +G+ D Sbjct: 406 SYALIDETGQIKYYK---NFKEVTSWSVPMHSAI----------DRLFSGALLGVKSDGF 452 Query: 560 VIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIV 596 V ++ + + I A VIW + +V Sbjct: 453 VYFFDWDNGTLVRRIDVNA------KDVIWSDNGELV 483 Score = 148 bits (374), Expect = 5e-36, Method: Composition-based stats. Identities = 43/218 (19%), Positives = 88/218 (40%), Gaps = 10/218 (4%) Query: 393 VPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSS 452 + S + ++P L G + + + + S +TE P+ Sbjct: 5 IKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQ-VTETPVRAG-- 61 Query: 453 CVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQS 512 K ++ VG D ++ V+ + HP I S+A ++++ Sbjct: 62 --KFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFE-AHPDYIRSIAVHPTKPYVLSGSDD 118 Query: 513 RKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVWNMNKPSDH 571 V ++ NN+ L T + H V CV+++P D A+G LD +V VW++ + + + Sbjct: 119 LTVKLWNWENNWALEQT--FEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPN 176 Query: 572 PIIIKGAH-AMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 + G ++ V+ ++ +++A D IK W+ Sbjct: 177 FTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWD 214 Score = 121 bits (303), Expect = 1e-27, Method: Composition-based stats. Identities = 73/436 (16%), Positives = 144/436 (33%), Gaps = 38/436 (8%) Query: 38 GTSVYTVPVGSLTDTEI---YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHI 94 G+ + + V + E + H P+ Y SG V++W+ Sbjct: 73 GSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENN-WA 131 Query: 95 LKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLT-GQARAMNSV 153 L+ T V ++++ + A G +R V+ T N LT GQ R +N V Sbjct: 132 LEQTFEGHEHFVMCVAFNPKDPSTFASG-CLDRTVKVWSLGQSTPNFTLTTGQERGVNYV 190 Query: 154 DF--KPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGD 211 D+ P +P+ +I+ SDD T+ I++ +T H V ++P + S D Sbjct: 191 DYYPLPDKPY-MITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSED 249 Query: 212 GTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTK-IASASADKTIKIWNVAT 270 GT+ ++N ++ + + P G K ++ D + ++ Sbjct: 250 GTLKIWNSSTYKVEKTLNVGLERS-------WCIATHPTGRKNYIASGFDNGFTVLSLGN 302 Query: 271 LKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAI--- 327 + ++ D ++W+ + S E D+ K + Sbjct: 303 DEPTLSL-------DPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKELGSV 355 Query: 328 ----TALSSSADGKTL-FSADAEGHINS---W-DISTGISNRVFPDVHATMITGIKTTSK 378 +L+ S +G+ + D E I + W + + G + I T + Sbjct: 356 DVFPQSLAHSPNGRFVTVVGDGEYVIYTALAWRNKAFGKCQDFVWGPDSNSYALIDETGQ 415 Query: 379 GDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIA--I 436 + + VP + + S D V + I Sbjct: 416 IKYYKNFKEVTSWSVPMHSAIDRLFSGALLGVKSDGFVYFFDWDNGTLVRRIDVNAKDVI 475 Query: 437 YSHGKLTEVPISYNSS 452 +S + ++ NS+ Sbjct: 476 WSDNGELVMIVNTNSN 491 Score = 108 bits (268), Expect = 1e-23, Method: Composition-based stats. Identities = 43/294 (14%), Positives = 94/294 (31%), Gaps = 17/294 (5%) Query: 315 SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIK 374 I + + + + + + G + W+ T + R + G Sbjct: 4 DIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKF 63 Query: 375 TTSKGDLFTVSWDDHLKVVP-AGGSGVDSSKAVANKLSS------QPLGLAVSADGDIAV 427 K + S D ++V G V +A + + S +P L+ S D + + Sbjct: 64 IARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKL 123 Query: 428 AACYKHIAIYSHGKLTEVPISYNSSCVALSN-DKQFVAVGGQDSKVHVYKLSGASVSEVK 486 + A+ T + CVA + D A G D V V+ L ++ + Sbjct: 124 WNWENNWALEQ----TFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTL 179 Query: 487 TIVHPAEITSVAFSN--NGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSW 544 T + V + + +++ + + + + H + V+ + Sbjct: 180 TTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTK---SCVATLEGHMSNVSFAVF 236 Query: 545 SPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSA 598 P + +GS D ++ +WN + + G + + + I S Sbjct: 237 HPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASG 290 Score = 81.1 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 17/159 (10%), Positives = 50/159 (31%), Gaps = 4/159 (2%) Query: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATD 510 + + +V +V ++ + + + F +++ Sbjct: 16 VKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTET-PVRAGKFIARKNWIIVGS 74 Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 ++ ++ ++ + H + ++ P + +GS D +V +WN Sbjct: 75 DDFRIRVFNYNTGEKVVD---FEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWA 131 Query: 571 HPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 +G + + +T S D +K W++ Sbjct: 132 LEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSL 170 Score = 37.9 bits (86), Expect = 0.012, Method: Composition-based stats. Identities = 12/85 (14%), Positives = 30/85 (35%), Gaps = 2/85 (2%) Query: 524 FELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSS 583 +L +++ + +V + + P + T V +WN + I + + Sbjct: 1 MKLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRA 60 Query: 584 VNSVIWLNETTIVSAGQDSNIKFWN 608 + + I+ D I+ +N Sbjct: 61 GKFIA--RKNWIIVGSDDFRIRVFN 83 >4V6W-Ag nrPDB Length = 318 Score = 192 bits (486), Expect = 5e-49, Method: Composition-based stats. Identities = 58/272 (21%), Positives = 109/272 (40%), Gaps = 27/272 (9%) Query: 53 EIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWD 112 + HSH + S G Y SG +R+WD + + V +++ Sbjct: 58 KRLYGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRR--FEGHTKDVLSVAFS 115 Query: 113 SESKRIAAVGEGRERFGHVFLFDT-GTSNGNLT--GQARAMNSVDFKPSRPF-RIISGSD 168 +++++I + + + L++T + G ++ V F P+ I+S Sbjct: 116 ADNRQIVSGSRDKT----IKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGW 171 Query: 169 DNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVF 228 D TV ++ K K+ H ++++V +PDGSL S G D +L++ DG Sbjct: 172 DRTVKVWNLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTL 231 Query: 229 EDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTI------PVGTR 282 E H+ + L +SP+ + A +IKIW++A K + + P Sbjct: 232 E--------HNDIINALCFSPNRYWLCVAYG-PSIKIWDLACKKTVEELRPEVVSPTSKA 282 Query: 283 IEDQQLGIIWT--KQALVSISANGFINFVNPE 312 + Q L + W+ Q L + ++ I Sbjct: 283 DQPQCLSLAWSTDGQTLFAGYSDNTIRVWQVS 314 Score = 178 bits (451), Expect = 6e-45, Method: Composition-based stats. Identities = 67/352 (19%), Positives = 121/352 (34%), Gaps = 48/352 (13%) Query: 135 DTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFK------FKSTFGE 188 +T G L G + + P P IIS S D T+ +++ + + Sbjct: 3 ETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYG 62 Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 H+ F+ V + DG+ S D T+ L++ G T FE H+ V + +S Sbjct: 63 HSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFE-------GHTKDVLSVAFS 115 Query: 249 PDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW--TKQALVSISANGFI 306 D +I S S DKTIK+WN G + + +VS + + Sbjct: 116 ADNRQIVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTV 175 Query: 307 NFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVH 366 N + +GHN + ++ S DG S + WD++ G + H Sbjct: 176 KVWNLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE--H 233 Query: 367 ATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIA 426 +I + + V++ +K+ +P ++ ++ D Sbjct: 234 NDIINALCFSPNRYWLCVAYGPSIKIW--------DLACKKTVEELRPEVVSPTSKAD-- 283 Query: 427 VAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLS 478 +A S D Q + G D+ + V+++S Sbjct: 284 ---------------------QPQCLSLAWSTDGQTLFAGYSDNTIRVWQVS 314 Score = 160 bits (404), Expect = 2e-39, Method: Composition-based stats. Identities = 63/346 (18%), Positives = 120/346 (34%), Gaps = 58/346 (16%) Query: 236 VAHSGSVFGLTWSP-DGTKIASASADKTIKIW------NVATLKVEKTIPVGTRIEDQQL 288 + H+G V + +P D I SAS DKT+ +W + +K + + + Sbjct: 12 IGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVV 71 Query: 289 GIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHI 348 + +S S + + + G + GH K + +++ SAD + + S + I Sbjct: 72 -LSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGSRDKTI 130 Query: 349 NSWDISTGISNRVFPDVHATMITGIKTTSKGD---LFTVSWDDHLKVVPAGGSGVDSSKA 405 W+ + D H ++ ++ + + + WD +KV Sbjct: 131 KLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWN--------LAN 182 Query: 406 VANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAV 465 K + + + V +S D Sbjct: 183 CKLKNN--------------------------------HHGHNGYLNTVTVSPDGSLCTS 210 Query: 466 GGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFL-VATDQSRKVIPYSVANNF 524 GG+DSK ++ L+ + T+ H I ++ FS N +L VA S K+ + Sbjct: 211 GGKDSKALLWDLNDGKN--LYTLEHNDIINALCFSPNRYWLCVAYGPSIKIWDLACKKTV 268 Query: 525 ELAHTN----SWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMN 566 E + + ++WS D L G DN++ VW ++ Sbjct: 269 EELRPEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQVS 314 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 48/304 (15%), Positives = 104/304 (34%), Gaps = 56/304 (18%) Query: 315 SIDQVRYGHNKAITALSSSA-DGKTLFSADAEGHINSWDISTGISN-----RVFPDVHAT 368 + GHN +T ++++ D T+ SA + + W ++ + H+ Sbjct: 6 QLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSH 65 Query: 369 MITGIKTTSKGDL-FTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAV 427 I+ + +S G+ + SWD L++ +G Sbjct: 66 FISDVVLSSDGNYALSGSWDQTLRLWDLAAG-----------------KTTRRFEGHTK- 107 Query: 428 AACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKT 487 + VA S D + + G +D + ++ ++ Sbjct: 108 ----------------------DVLSVAFSADNRQIVSGSRDKTIKLWNTLAECKFTIQE 145 Query: 488 IVHPAEITSVAFSNN--GAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWS 545 H ++ V FS N +V+ R V +++AN N+ H + V+ S Sbjct: 146 DGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLAN---CKLKNNHHGHNGYLNTVTVS 202 Query: 546 PDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIK 605 PD +G D+ ++W++N + + +N++ + + +IK Sbjct: 203 PDGSLCTSGGKDSKALLWDLNDGKNLYTL----EHNDIINALCFSPNRYWLCVAYGPSIK 258 Query: 606 FWNV 609 W++ Sbjct: 259 IWDL 262 Score = 119 bits (297), Expect = 4e-27, Method: Composition-based stats. Identities = 38/257 (14%), Positives = 80/257 (31%), Gaps = 8/257 (3%) Query: 15 RTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYC 74 V+ + + ++ + G T + H+ S Sbjct: 64 SHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKT--TRRFEGHTKDVLSVAFSADNRQI 121 Query: 75 ASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLF 134 SG +++W+T + V + + V G +R V+ Sbjct: 122 VSGSRDKTIKLWNTLAECK-FTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNL 180 Query: 135 DTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVH 194 N G +N+V P SG D+ +++ K T H ++ Sbjct: 181 ANCKLKNNHHGHNGYLNTVTVSPDGSLC-TSGGKDSKALLWDLNDGKNLYTLE-HNDIIN 238 Query: 195 SVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV--AHSGSVFGLTWSPDGT 252 ++ ++P+ +I +++ + + A L WS DG Sbjct: 239 ALCFSPNRYWLCVA-YGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQ 297 Query: 253 KIASASADKTIKIWNVA 269 + + +D TI++W V+ Sbjct: 298 TLFAGYSDNTIRVWQVS 314 >5FVM-C nrPDB Length = 303 Score = 191 bits (484), Expect = 9e-49, Method: Composition-based stats. Identities = 60/307 (19%), Positives = 119/307 (38%), Gaps = 25/307 (8%) Query: 74 CASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFL 133 AS +R W+ T + TI V + S+ K +AA G HV L Sbjct: 5 LASAGYDHTIRFWEAL--TGVCSRTIQHADSQVNRLEITSDKKYLAAAGH-----LHVRL 57 Query: 134 FDTGTSNGN----LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEH 189 +D ++N N G + S+ F+ + ++S S+D T+ +++ + + H Sbjct: 58 YDIRSNNPNPVSSFEGHKGNVTSIAFQQENRW-MVSSSEDGTIKVWDVRSPSVQRNYK-H 115 Query: 190 TKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP 249 V+ V +P+ S DG I +++ + T + + + L+ + Sbjct: 116 NAPVNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPED------NTPLQSLSVAS 169 Query: 250 DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGI-----IWTKQALVSISANG 304 DG+ + + + +W + T+ T+ + I + L + SA+ Sbjct: 170 DGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADH 229 Query: 305 FINFVNPELG-SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFP 363 N E ++ GH + + + SAD L +A ++ ++ WD+ST R + Sbjct: 230 TARVWNIEDNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQYG 289 Query: 364 DVHATMI 370 H + Sbjct: 290 GHHKGAV 296 Score = 131 bits (328), Expect = 1e-30, Method: Composition-based stats. Identities = 43/287 (14%), Positives = 81/287 (28%), Gaps = 57/287 (19%) Query: 163 IISGSDDNTVAIFEGPPFKFKST------------------------------------- 185 + S D+T+ +E T Sbjct: 5 LASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHLHVRLYDIRSNN 64 Query: 186 ------FGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHS 239 F H V S+ + + S+ DGTI +++ + ++ H+ Sbjct: 65 PNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK--------HN 116 Query: 240 GSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVS 299 V + P+ ++ S D I+IW++ + + Q L + LV+ Sbjct: 117 APVNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVA 176 Query: 300 ISANGFINFV------NPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 + G + H K IT + SAD K L + A+ W+I Sbjct: 177 GNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNI 236 Query: 354 STGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGV 400 D H + ++ + DH + + Sbjct: 237 EDNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSE 283 Score = 124 bits (312), Expect = 9e-29, Method: Composition-based stats. Identities = 55/307 (17%), Positives = 116/307 (37%), Gaps = 23/307 (7%) Query: 253 KIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPE 312 +ASA D TI+ W T +TI + +L I K+ L + + + + Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQ-HADSQVNRLEITSDKKYLAAAG-HLHVRLYDIR 61 Query: 313 LGSID--QVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMI 370 + + GH +T+++ + + + S+ +G I WD+ + R + H + Sbjct: 62 SNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK--HNAPV 119 Query: 371 TGIKTTSK-GDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAA 429 + G+L + D ++++ G + + + + ++ L+V++DG + VA Sbjct: 120 NEVAIHPNQGELISCDQDGNIRIWDLGEN--QCTNQLTPEDNTPLQSLSVASDGSMLVAG 177 Query: 430 C-------YKHIAIYSHGKLTEV----PISYNSSCVALSNDKQFVAVGGQDSKVHVYKLS 478 ++ L V + + V LS D + +A D V+ + Sbjct: 178 NNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIE 237 Query: 479 GASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAK 538 E H + AFS + A+LV V + ++ + + + H Sbjct: 238 DNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQ---YGGHHKG 294 Query: 539 VACVSWS 545 CV+ + Sbjct: 295 AVCVALN 301 Score = 117 bits (293), Expect = 1e-26, Method: Composition-based stats. Identities = 47/285 (16%), Positives = 104/285 (36%), Gaps = 22/285 (7%) Query: 338 TLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGG 397 L SA + I W+ TG+ +R + + ++ TS + H+++ Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTI-QHADSQVNRLEITSDKKYLAAAGHLHVRLYDIRS 62 Query: 398 SGVDSSKAVAN---------KLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPIS 448 + + + ++ S DG I V ++ V Sbjct: 63 NNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYKHNAPV--- 119 Query: 449 YNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVA 508 + VA+ ++ + QD + ++ L + T + S++ +++G+ LVA Sbjct: 120 ---NEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVA 176 Query: 509 TDQSRKVIPYSVANNFE---LAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM 565 + + + ++ + L + HT + V S D LAT S D++ VWN+ Sbjct: 177 GNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNI 236 Query: 566 NKPSDHPIIIKGAHAMSSVNSVIWL-NETTIVSAGQDSNIKFWNV 609 ++ + V + + +V+A D ++ W++ Sbjct: 237 --EDNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDL 279 >3JB9-g nrPDB Length = 558 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 52/308 (16%), Positives = 117/308 (37%), Gaps = 21/308 (6%) Query: 55 YTEHSHQTTVAKTSP-SGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS 113 + H+ + + P SG+ SG + ++IW+ +L+ T + P++D+S+ Sbjct: 262 WKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLR-TFQGHARPIRDLSFSQ 320 Query: 114 ESKRIAAVGEGRERFGHVFLFDTGTSNG-NLTGQARAMNSVDFK--PSRPFRIISGSDDN 170 + + + + + L+DT N R N V F+ P +P ++G+ D Sbjct: 321 DGRSFLSTSFDKT----IKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADK 376 Query: 171 TVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFED 230 + F+ + H ++S+ + +G F +T D ++ + D Sbjct: 377 RILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPIKFVAD 436 Query: 231 DSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPV----GTRIEDQ 286 ++ HS + P+G IA S D I +++ + V Sbjct: 437 IAM----HSMP--RVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSL 490 Query: 287 QLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADA-- 344 ++G + + S ++G F + + + H+ + +++ + + + Sbjct: 491 EVGFSPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIV 550 Query: 345 EGHINSWD 352 +G I WD Sbjct: 551 DGSIKYWD 558 Score = 152 bits (384), Expect = 4e-37, Method: Composition-based stats. Identities = 65/347 (18%), Positives = 106/347 (30%), Gaps = 49/347 (14%) Query: 179 PFKFKSTFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSL--KN 235 P K T+ HTK + +R+ P G L S D I ++ V+ D SL Sbjct: 255 PKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWE--------VYHDRSLLRTF 306 Query: 236 VAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQ 295 H+ + L++S DG S S DKTIK+W+ K + + K Sbjct: 307 QGHARPIRDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKP 366 Query: 296 A-LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIS 354 ++ +A+ I + I Q H I +++ +GK + + + W+ Sbjct: 367 NEFLAGTADKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYG 426 Query: 355 TGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQP 414 T + + D+ + + G Sbjct: 427 TPVPIKFVADIAMHSMPRVALRPNGKSIACQ----------------------------- 457 Query: 415 LGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHV 474 S D I V + Y+ S S V S D +FV G Sbjct: 458 -----SLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSPDGRFVFSGDSSGNACF 512 Query: 475 YKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQ--SRKVIPYS 519 + K H + S+AF VAT + + Sbjct: 513 WDWKT-CKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKYWD 558 Score = 121 bits (303), Expect = 1e-27, Method: Composition-based stats. Identities = 51/298 (17%), Positives = 96/298 (32%), Gaps = 16/298 (5%) Query: 280 GTRIEDQQLGIIW-TKQALVSISANGFINFVNP-ELGSIDQVRYGHNKAITALSSSADGK 337 G L + L+S S + I S+ + GH + I LS S DG+ Sbjct: 264 GHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDGR 323 Query: 338 TLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGG 397 + S + I WD G F T + ++ +++ Sbjct: 324 SFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDI 383 Query: 398 SGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVP-----ISYNSS 452 D +A + L + + + + +G + ++ Sbjct: 384 RSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPIKFVADIAMHSMP 443 Query: 453 CVALSNDKQFVAVGGQDSKVHVY----KLSGASVSEVKTIVHPAEITSVAFSNNGAFLVA 508 VAL + + +A D+ ++VY K K V FS +G F+ + Sbjct: 444 RVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSPDGRFVFS 503 Query: 509 TDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGS-LDNSVIVWN 564 D S + H+ V +++ P + ++AT S +D S+ W+ Sbjct: 504 GDSSGNACFWDWKT---CKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKYWD 558 Score = 84.5 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 30/168 (17%), Positives = 64/168 (38%), Gaps = 12/168 (7%) Query: 446 PISYNSSCVALSN-DKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGA 504 + SC+ + G D+++ ++++ H I ++FS +G Sbjct: 264 GHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDGR 323 Query: 505 FLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPD---NVRLATGSLDNSVI 561 ++T + + + L NS CV + D G+ D ++ Sbjct: 324 SFLSTSFDKTIKLWDTELGKCLNCFNSDR----LTNCVKFQVDPDKPNEFLAGTADKRIL 379 Query: 562 VWNMNKPSDHPIIIKGAHAMSSVNSVIWL-NETTIVSAGQDSNIKFWN 608 +++ P I+ H + +NS+ +L N V+ DS+++FW Sbjct: 380 QFDIRSPD---IVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWE 424 Score = 63.4 bits (152), Expect = 3e-10, Method: Composition-based stats. Identities = 18/87 (20%), Positives = 37/87 (42%), Gaps = 4/87 (4%) Query: 524 FELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMS 582 H +W HT ++C+ + P L +GS+DN + +W + D ++ Sbjct: 254 IPKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEV--YHDRSLLRTFQGHAR 311 Query: 583 SVNSVIWL-NETTIVSAGQDSNIKFWN 608 + + + + + +S D IK W+ Sbjct: 312 PIRDLSFSQDGRSFLSTSFDKTIKLWD 338 Score = 32.2 bits (71), Expect = 0.62, Method: Composition-based stats. Identities = 12/72 (16%), Positives = 23/72 (31%), Gaps = 3/72 (4%) Query: 19 GTAVVLGNTPAGDKI-QYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPS--GYYCA 75 G ++ +G +P G + + + + HS P Sbjct: 487 GYSLEVGFSPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQETSKVAT 546 Query: 76 SGDVHGNVRIWD 87 S V G+++ WD Sbjct: 547 SSIVDGSIKYWD 558 >5NZU-C nrPDB Length = 905 Score = 190 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 80/506 (15%), Positives = 159/506 (31%), Gaps = 40/506 (7%) Query: 54 IYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS 113 T S + P+ + + +G+V +W+ T L T V PV+ + + Sbjct: 10 KLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWN--HETQTLVKTFEVCDLPVRAAKFVA 67 Query: 114 ESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVA 173 + + VF ++T + + + P++PF I++ SDD + Sbjct: 68 RKNWVVTGADD--MQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPF-ILTSSDDMLIK 124 Query: 174 IFEG-PPFKFKSTFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDD 231 +++ + F HT +V + NP D + FAS D TI ++ + E Sbjct: 125 LWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLE-- 182 Query: 232 SLKNVAHSGSVFGLTWSP--DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLG 289 H V + + D + S + D+ +KIW+ +T+ + Sbjct: 183 -----GHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQ-NVSCAS 236 Query: 290 IIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHIN 349 +++ S +G + + ++ + + ++S + EG I Sbjct: 237 FHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSII 296 Query: 350 SWDISTGISN-RVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVAN 408 + G + D + +I + + D +K V + Sbjct: 297 ---VKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDTEIKDGERLPLAVKDMGSC-- 351 Query: 409 KLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQ 468 P + + +G V IY+ L A ++D A+ Sbjct: 352 --EIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSFGSAQE-FAWAHDSSEYAIRES 408 Query: 469 DSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAH 528 +S V ++K S K I G FL+ + Y N + Sbjct: 409 NSIVKIFKNFKEKKS-FKPDFGAESIY-------GGFLLGVRSVNGLAFYDWENTELIRR 460 Query: 529 TNSWTFHTAKVACVSWSPDNVRLATG 554 H + WS + Sbjct: 461 IEIQPKH------IFWSDSGELVCIA 480 Score = 173 bits (439), Expect = 2e-43, Method: Composition-based stats. Identities = 62/386 (16%), Positives = 140/386 (36%), Gaps = 24/386 (6%) Query: 95 LKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVD 154 +K + S VK + + A V+ +T T + + Sbjct: 7 IKRKLTARSDRVKSVDLHPTEPWMLAS--LYNGSVCVWNHETQTLVKTFEVCDLPVRAAK 64 Query: 155 FKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTI 214 F + + +++G+DD + +F + F H+ ++ + +P ++ D I Sbjct: 65 FVARKNW-VVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLI 123 Query: 215 VLYNG-VDGTKTGVFEDDSLKNVAHSGSVFGLTWSP-DGTKIASASADKTIKIWNVATLK 272 L++ + + VFE H+ V + +P D + ASAS D+TIK+W + + Sbjct: 124 KLWDWDKKWSCSQVFE-------GHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSS 176 Query: 273 VEKTIPVGTRIEDQQLGII-WTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALS 331 T+ + + K L+S + + + + + + Q GH + ++ S Sbjct: 177 PNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCAS 236 Query: 332 SSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLK 391 + + + +G + W ST + + + + + + +D+ Sbjct: 237 FHPELPIIITGSEDGTVRIWHSST-YRLESTLNYGMERVWCVASLRGSNNVALGYDEGSI 295 Query: 392 VVPAGGS----GVDSSKAVANKLSSQPLGLAVSADGDIAVAACYK-HIAIYSHGKLTEVP 446 +V G +D++ + S+ + A GD + + +A+ G P Sbjct: 296 IVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDTEIKDGERLPLAVKDMGSCEIYP 355 Query: 447 ISYNSSCVALSNDKQFVAVGGQDSKV 472 + + + +FV V G + Sbjct: 356 QTIQHN-----PNGRFVVVCGDGEYI 376 Score = 131 bits (329), Expect = 9e-31, Method: Composition-based stats. Identities = 34/209 (16%), Positives = 75/209 (35%), Gaps = 9/209 (4%) Query: 401 DSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDK 460 + ++P LA +G + C + + K EV K Sbjct: 15 SDRVKSVDLHPTEPWMLASLYNGSV----CVWNHETQTLVKTFEV-CDLPVRAAKFVARK 69 Query: 461 QFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSV 520 +V G D ++ V+ + + H I +A F++ + + + Sbjct: 70 NWVVTGADDMQIRVFNYNTLERVHMFE-AHSDYIRCIAVHPTQPFILTSSDDMLIKLWDW 128 Query: 521 ANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAH 579 + + + HT V + +P DN + A+ SLD ++ VW + S + + Sbjct: 129 DKKWSCSQ--VFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEK 186 Query: 580 AMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 ++ ++ ++ ++S D +K W+ Sbjct: 187 GVNCIDYYSGGDKPYLISGADDRLVKIWD 215 Score = 128 bits (321), Expect = 8e-30, Method: Composition-based stats. Identities = 35/221 (15%), Positives = 80/221 (36%), Gaps = 12/221 (5%) Query: 45 PVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSG 104 +L ++ HS P+ + + +++WD + Sbjct: 85 NYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD-WDKKWSCSQVFEGHTH 143 Query: 105 PVKDISWDS-ESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDF-KPSRPFR 162 V I + ++ + A+ +R V+ + + N L G + +N +D+ Sbjct: 144 YVMQIVINPKDNNQFASAS--LDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPY 201 Query: 163 IISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDG 222 +ISG+DD V I++ T H + V ++P+ + + DGT+ +++ Sbjct: 202 LISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWH---- 257 Query: 223 TKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTI 263 + + +S N V+ + +A + +I Sbjct: 258 --SSTYRLESTLNYGMER-VWCVASLRGSNNVALGYDEGSI 295 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 53/306 (17%), Positives = 100/306 (32%), Gaps = 26/306 (8%) Query: 181 KFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSG 240 K + V SV +P ++ +G++ ++N T FE L Sbjct: 6 DIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDL------- 58 Query: 241 SVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSI 300 V + + + + D I+++N TL+ + + + + T+ +++ Sbjct: 59 PVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSD-YIRCIAVHPTQPFILTS 117 Query: 301 SANGFINFVNPELG-SIDQVRYGHNKAITALSSSA-DGKTLFSADAEGHINSWDISTGIS 358 S + I + + S QV GH + + + D SA + I W + + Sbjct: 118 SDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSP 177 Query: 359 NRVFPDVHATMITGIKTTSKGDL----------FTVSWDDHLKVVPAGGSGVDSSKAVAN 408 N H + I S GD WD K G + + A+ Sbjct: 178 NFTLEG-HEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCAS 236 Query: 409 KLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQ 468 P+ + S DG + + + S + CVA VA+G Sbjct: 237 FHPELPIIITGSEDGTVRIWHS-STYRLESTLNYGMERVW----CVASLRGSNNVALGYD 291 Query: 469 DSKVHV 474 + + V Sbjct: 292 EGSIIV 297 Score = 114 bits (285), Expect = 1e-25, Method: Composition-based stats. Identities = 48/294 (16%), Positives = 100/294 (34%), Gaps = 13/294 (4%) Query: 315 SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIK 374 I + + + ++ + ++ G + W+ T + F + Sbjct: 6 DIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKF 65 Query: 375 TTSKGDLFTVSWDDHLKVVPAGG-SGVDSSKAVANKLSS---QPLGLAVSADGDIAVAAC 430 K + T + D ++V V +A ++ + P + D + Sbjct: 66 VARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKL 125 Query: 431 YKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVH 490 + +S ++ E Y V D A D + V++L G+S H Sbjct: 126 WDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQL-GSSSPNFTLEGH 184 Query: 491 PAEITSVAFSN--NGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDN 548 + + + + + +L++ R V + N + + H V+C S+ P+ Sbjct: 185 EKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQ---TLEGHAQNVSCASFHPEL 241 Query: 549 VRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDS 602 + TGS D +V +W S + + + M V V L + V+ G D Sbjct: 242 PIIITGSEDGTVRIW---HSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDE 292 Score = 83.8 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 22/159 (13%), Positives = 55/159 (34%), Gaps = 4/159 (2%) Query: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATD 510 V L + ++ + V V+ ++ + + + + F ++V Sbjct: 18 VKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVC-DLPVRAAKFVARKNWVVTGA 76 Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 ++ ++ L + + H+ + C++ P + T S D + +W+ +K Sbjct: 77 DDMQIRVFNYNT---LERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWS 133 Query: 571 HPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 + +G + + SA D IK W + Sbjct: 134 CSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQL 172 >3JB9-L nrPDB Length = 340 Score = 189 bits (480), Expect = 3e-48, Method: Composition-based stats. Identities = 61/306 (19%), Positives = 120/306 (39%), Gaps = 23/306 (7%) Query: 54 IYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS 113 H+ + VA+ PSG Y ASG + + +W+ + G + D+ W Sbjct: 45 QMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGV-LNGCKGAITDLQWSR 103 Query: 114 ESKRIAAVGEGRERFGHVFLFD--TGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNT 171 +S+ + H+ +D +G G A +N++D + S SDD T Sbjct: 104 DSRVVYCSSSDT----HLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCT 159 Query: 172 VAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDD 231 + +++ T E + +V G+ G DG I +++ + + V + Sbjct: 160 MKVWDSRSKDCIKTIEEKY-PLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLK-- 216 Query: 232 SLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNV---ATLKVEKTIPVG--TRIEDQ 286 H + L S DG+ + S S D T++I++V A+ + + I G E Sbjct: 217 -----GHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHN 271 Query: 287 QLGIIWTKQALV--SISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADA 344 LG+ W++ + + S++ + + G + V GH ++ + + S + Sbjct: 272 LLGVAWSRNSRFVGAGSSDKNVYVWS-ATGDLRYVLPGHEGSVNHVDFHPHQDIILSCSS 330 Query: 345 EGHINS 350 + I Sbjct: 331 DRTIFL 336 Score = 147 bits (371), Expect = 1e-35, Method: Composition-based stats. Identities = 60/346 (17%), Positives = 119/346 (34%), Gaps = 45/346 (13%) Query: 135 DTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEG-PPFKFKSTFGEHTKFV 193 D N + G + F PS + SG D + ++ K + Sbjct: 38 DLNVPNLQMFGHTAEVLVARFDPSGSY-FASGGMDRQILLWNVFGDVKNYGVLNGCKGAI 96 Query: 194 HSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTK 253 ++++ D + + D ++ ++ V G K K+ H+G V L G++ Sbjct: 97 TDLQWSRDSRVVYCSSSDTHLMSWDAVSGQKIR-------KHKGHAGVVNALDVLKVGSE 149 Query: 254 IASA-SADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPE 312 + ++ S D T+K+W+ + KTI + + I + +G I + Sbjct: 150 LLTSVSDDCTMKVWDSRSKDCIKTIEEKYPLTA--VAIAQQGTQVFIGGIDGAIKIWDLR 207 Query: 313 LGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITG 372 V GH IT+L+ S DG +L S + + +D+ S + + I G Sbjct: 208 NNHCSHVLKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHG 267 Query: 373 IKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYK 432 + +L V+W + + V AG S D ++ V + Sbjct: 268 ----QEHNLLGVAWSRNSRFVGAGSS-----------------------DKNVYVWSATG 300 Query: 433 HIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLS 478 + G + + V + + D + + +L+ Sbjct: 301 DLRYVLPGH------EGSVNHVDFHPHQDIILSCSSDRTIFLGELN 340 Score = 120 bits (301), Expect = 2e-27, Method: Composition-based stats. Identities = 57/300 (19%), Positives = 102/300 (34%), Gaps = 26/300 (8%) Query: 320 RYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKG 379 +GH + G S + I W++ + N + IT ++ + Sbjct: 46 MFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDS 105 Query: 380 DLFTVSWDDHLKVVPA--GGSGVDSSKAVANKLSS-------QPLGLAVSADGDIAVAAC 430 + S D + G + K A +++ L +VS D + V Sbjct: 106 RVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDS 165 Query: 431 YKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVH 490 S + + Y + VA++ V +GG D + ++ L S V H Sbjct: 166 R------SKDCIKTIEEKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLK-GH 218 Query: 491 PAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHT-----NSWTFHTAKVACVSWS 545 ITS+A S +G+ L++ V + V + + V+WS Sbjct: 219 KDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWS 278 Query: 546 PDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW-LNETTIVSAGQDSNI 604 ++ + GS D +V VW+ SVN V + ++ I+S D I Sbjct: 279 RNSRFVGAGSSDKNVYVWSATGDLR----YVLPGHEGSVNHVDFHPHQDIILSCSSDRTI 334 Score = 118 bits (296), Expect = 6e-27, Method: Composition-based stats. Identities = 53/352 (15%), Positives = 111/352 (31%), Gaps = 53/352 (15%) Query: 223 TKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTR 282 +T +L+ H+ V + P G+ AS D+ I +WNV + G + Sbjct: 34 QRTSDLNVPNLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCK 93 Query: 283 IEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGK-TLFS 341 L + + S++ + + G + GH + AL G L S Sbjct: 94 GAITDLQWSRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTS 153 Query: 342 ADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVD 401 + + WD + + +T + +G + G+D Sbjct: 154 VSDDCTMKVWDSRSKDCIKTIE--EKYPLTAVAIAQQGTQVFIG-------------GID 198 Query: 402 SSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQ 461 + + + ++ + G + + +A+S D Sbjct: 199 GAIKIWDLRNNH---CSHVLKGHKDI-----------------------ITSLAISKDGS 232 Query: 462 FVAVGGQDSKVHVYKLS-----GASVSEVKTIVHPAE--ITSVAFSNNGAFLVATDQSRK 514 + D+ V ++ + + + +H E + VA+S N F+ A + Sbjct: 233 SLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKN 292 Query: 515 VIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMN 566 V +S + H V V + P + + S D ++ + +N Sbjct: 293 VYVWSATGDLR----YVLPGHEGSVNHVDFHPHQDIILSCSSDRTIFLGELN 340 Score = 76.1 bits (185), Expect = 4e-14, Method: Composition-based stats. Identities = 25/170 (14%), Positives = 49/170 (28%), Gaps = 7/170 (4%) Query: 441 KLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFS 500 L + + A GG D ++ ++ + G + IT + +S Sbjct: 43 NLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWS 102 Query: 501 NNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATG-SLDNS 559 + + + ++ + + H V + L T S D + Sbjct: 103 RDSRVVYCSSSDTHLMSWDAVSG---QKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCT 159 Query: 560 VIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 + VW+ I I T + G D IK W++ Sbjct: 160 MKVWDSRSKDCIKTI---EEKYPLTAVAIAQQGTQVFIGGIDGAIKIWDL 206 Score = 68.4 bits (165), Expect = 9e-12, Method: Composition-based stats. Identities = 21/132 (15%), Positives = 54/132 (40%), Gaps = 3/132 (2%) Query: 477 LSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHT 536 S +V ++ H AE+ F +G++ + R+++ ++V + + + Sbjct: 36 TSDLNVPNLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVK--NYGVLNGCK 93 Query: 537 AKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIV 596 + + WS D+ + S D ++ W+ A +++++ + +E + Sbjct: 94 GAITDLQWSRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSE-LLT 152 Query: 597 SAGQDSNIKFWN 608 S D +K W+ Sbjct: 153 SVSDDCTMKVWD 164 >6HQA-B nrPDB Length = 722 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 57/290 (19%), Positives = 108/290 (37%), Gaps = 31/290 (10%) Query: 47 GSLTDTEIYTEHS--HQTTVAKTSPSGYYCASGDVHGNVRIW-------------DTTQT 91 SL +YT H+ + T K + ASG +++W D Sbjct: 376 ASLPSVCMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQ 435 Query: 92 THI------LKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTG 145 + + SG V + + +++ + + E + ++ DT T + G Sbjct: 436 QNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDK--TVRLWSLDTYTCLVSYKG 493 Query: 146 QARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLF 205 + ++ V F P + + S D T ++ F H V V ++P+ + Sbjct: 494 HSSSVWDVKFSPMGHY-FATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYL 552 Query: 206 ASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKI 265 + D T +++ G VF + HSG++ L SPDG +ASA D + + Sbjct: 553 FTGSSDKTARMWDIARGECVRVF-------MGHSGAINCLAVSPDGRWLASAGEDSVVCL 605 Query: 266 WNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGS 315 W+++T + K + R L LVS A+ + + + + Sbjct: 606 WDISTGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVKKNT 655 Score = 188 bits (477), Expect = 6e-48, Method: Composition-based stats. Identities = 63/347 (18%), Positives = 122/347 (35%), Gaps = 34/347 (9%) Query: 138 TSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFG---------- 187 + + F + SG D+ + ++ +S Sbjct: 381 VCMYTFHNTNNDLTCLKFN-DDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNND 439 Query: 188 -----------EHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV 236 H+ V+ V ++PD S D T+ L++ T ++ Sbjct: 440 GVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYK------- 492 Query: 237 AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA 296 HS SV+ + +SP G A+AS D+T ++W+ + + I G + + Sbjct: 493 GHSSSVWDVKFSPMGHYFATASHDQTARLWSCDHIYPLR-IFAGHLNDVDCVEFHPNSTY 551 Query: 297 LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 L + S++ + G +V GH+ AI L+ S DG+ L SA + + WDISTG Sbjct: 552 LFTGSSDKTARMWDIARGECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTG 611 Query: 357 ISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLG 416 + + I + + +G + + D+ V +S A ++ Sbjct: 612 RRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVKKNTNSPSAQPEPINDVTAQ 671 Query: 417 LAVSADGDIA----VAACYKHIAIYSHGKLTEVPISYNSSCVALSND 459 D+ + A H+++Y K + + + L+ Sbjct: 672 GIQKKTEDLRRRKEIVATNDHMSVYFTKKTPVYTVHFTRRNLCLAGG 718 Score = 168 bits (424), Expect = 7e-42, Method: Composition-based stats. Identities = 72/394 (18%), Positives = 128/394 (32%), Gaps = 72/394 (18%) Query: 179 PFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNG--------------VDGTK 224 P TF + +++N D ++ AS D I L++ Sbjct: 379 PSVCMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNN 438 Query: 225 TGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIE 284 GV S + V HSG+V+G+ +SPD + S S DKT+++W++ T + + Sbjct: 439 DGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSV 498 Query: 285 DQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADA 344 + S + + + ++ GH + + + LF+ + Sbjct: 499 WDVK-FSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSS 557 Query: 345 EGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSK 404 + WDI+ G RVF H+ I + + G + +D + + +G K Sbjct: 558 DKTARMWDIARGECVRVFMG-HSGAINCLAVSPDGRWLASAGEDSVVCLWDISTG-RRIK 615 Query: 405 AVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVA 464 A+ S LA S +G + + Sbjct: 616 AMRGHGRSSIYSLAFSREGTV-------------------------------------LV 638 Query: 465 VGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNF 524 G D+ V V+ + + S P I V T Q + + Sbjct: 639 STGADNSVRVWDVKKNTNSP---SAQPEPINDV-----------TAQGIQKKTEDLRRRK 684 Query: 525 ELAHTNSWTF----HTAKVACVSWSPDNVRLATG 554 E+ TN V V ++ N+ LA G Sbjct: 685 EIVATNDHMSVYFTKKTPVYTVHFTRRNLCLAGG 718 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 49/295 (16%), Positives = 98/295 (33%), Gaps = 26/295 (8%) Query: 316 IDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKT 375 + N +T L + D + S + I W I + + Sbjct: 382 CMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQ------ 435 Query: 376 TSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIA 435 D V L G + + ++ S D + + + + Sbjct: 436 -QNNDGVAVKGSRRLV-------GHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTC 487 Query: 436 IYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEIT 495 + S+ S + V S + A D ++ + H ++ Sbjct: 488 LVSYK-----GHSSSVWDVKFSPMGHYFATASHDQTARLWSCDHIYPLRIF-AGHLNDVD 541 Query: 496 SVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGS 555 V F N +L + + +A + H+ + C++ SPD LA+ Sbjct: 542 CVEFHPNSTYLFTGSSDKTARMWDIARG---ECVRVFMGHSGAINCLAVSPDGRWLASAG 598 Query: 556 LDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNE-TTIVSAGQDSNIKFWNV 609 D+ V +W+++ + I H SS+ S+ + E T +VS G D++++ W+V Sbjct: 599 EDSVVCLWDIS--TGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDV 651 Score = 144 bits (363), Expect = 9e-35, Method: Composition-based stats. Identities = 33/212 (15%), Positives = 78/212 (36%), Gaps = 7/212 (3%) Query: 27 TPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRI 85 +P + C+ + + + T Y HS K SP G+Y A+ R+ Sbjct: 462 SPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPMGHYFATASHDQTARL 521 Query: 86 WDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTG 145 W + V + + S + + ++ G G Sbjct: 522 WSCDHIYPL--RIFAGHLNDVDCVEFHPNSTYLFTGSSDK--TARMWDIARGECVRVFMG 577 Query: 146 QARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEH-TKFVHSVRYNPDGSL 204 + A+N + P + + S +D+ V +++ + H ++S+ ++ +G++ Sbjct: 578 HSGAINCLAVSPDGRW-LASAGEDSVVCLWDISTGRRIKAMRGHGRSSIYSLAFSREGTV 636 Query: 205 FASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV 236 STG D ++ +++ T + + + + +V Sbjct: 637 LVSTGADNSVRVWDVKKNTNSPSAQPEPINDV 668 Score = 119 bits (297), Expect = 4e-27, Method: Composition-based stats. Identities = 39/234 (16%), Positives = 83/234 (35%), Gaps = 25/234 (10%) Query: 396 GGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVA 455 D+ +A+ D + ++ S T + + +C+ Sbjct: 338 NNPSKDTLPLPLKSAQDLRNDIAMIQDSRAKIKLSAAQASLPSVCMYTFHNTNNDLTCLK 397 Query: 456 LSNDKQFVAVGGQDSKVHVYKLSGASVSEVKT--------------------IVHPAEIT 495 ++D VA G QDS + ++ + G+ + + + H + Sbjct: 398 FNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLVGHSGAVY 457 Query: 496 SVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGS 555 V FS + +L++ + + V +S+ L S+ H++ V V +SP AT S Sbjct: 458 GVDFSPDNRYLISCSEDKTVRLWSLDTYTCLV---SYKGHSSSVWDVKFSPMGHYFATAS 514 Query: 556 LDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 D + +W+ + I + + V N T + + D + W++ Sbjct: 515 HDQTARLWSCDHIYPLRIFAGHLNDVDCVEF--HPNSTYLFTGSSDKTARMWDI 566 Score = 56.8 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 11/116 (9%), Positives = 41/116 (35%), Gaps = 19/116 (16%) Query: 514 KVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPI 573 K+ + + ++ + C+ ++ D+ +A+G D+ + +W+++ + Sbjct: 368 KIKLSAAQASLPSVCMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSL 427 Query: 574 II-------------------KGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNVP 610 + H+ + + ++S +D ++ W++ Sbjct: 428 LKNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLD 483 >6G51-g nrPDB Length = 317 Score = 188 bits (477), Expect = 6e-48, Method: Composition-based stats. Identities = 60/273 (21%), Positives = 113/273 (41%), Gaps = 27/273 (9%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSE 114 HSH + S G + SG G +R+WD T T + + V +++ S+ Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRR--FVGHTKDVLSVAFSSD 116 Query: 115 SKRIAAVGEGRERFGHVFLFDT-GTSNGNL--TGQARAMNSVDFKPSRPF-RIISGSDDN 170 +++I + + + L++T G + + ++ V F P+ I+S D Sbjct: 117 NRQIVSGSRDKT----IKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172 Query: 171 TVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFED 230 V ++ K K+ HT ++++V +PDGSL AS G DG +L++ +G + Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232 Query: 231 DSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWN------VATLKVEKTIPVGTRIE 284 + + L +SP+ + +A+ +IKIW+ V LK E Sbjct: 233 GDI--------INALCFSPNRYWLCAATG-PSIKIWDLEGKIIVDELKQEVISTSSKAEP 283 Query: 285 DQQLGIIWT--KQALVSISANGFINFVNPELGS 315 Q + W+ Q L + + + +G+ Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 Score = 182 bits (461), Expect = 5e-46, Method: Composition-based stats. Identities = 68/351 (19%), Positives = 117/351 (33%), Gaps = 47/351 (13%) Query: 138 TSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFK-----FKSTFGEHTKF 192 T G L G + + P P I+S S D T+ +++ + + H+ F Sbjct: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHF 65 Query: 193 VHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGT 252 V V + DG S DGT+ L++ GT T F V H+ V + +S D Sbjct: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRF-------VGHTKDVLSVAFSSDNR 118 Query: 253 KIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW--TKQALVSISANGFINFVN 310 +I S S DKTIK+WN + + + +VS + + N Sbjct: 119 QIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 Query: 311 PELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMI 370 + GH + ++ S DG S +G WD++ G +I Sbjct: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD--II 236 Query: 371 TGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAAC 430 + + + +K+ G + Sbjct: 237 NALCFSPNRYWLCAATGPSIKIWDLEGKIIVDE--------------------------- 269 Query: 431 YKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGAS 481 K I + K + +A S D Q + G D+ V V++++ + Sbjct: 270 LKQEVISTSSKAEPPQC----TSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 Score = 168 bits (425), Expect = 6e-42, Method: Composition-based stats. Identities = 67/321 (20%), Positives = 123/321 (38%), Gaps = 29/321 (9%) Query: 53 EIYTEHSHQTTVAKTSPSG-YYCASGDVHGNVRIWDTTQTTHIL---KTTIPVFSGPVKD 108 H+ T T+P S + +W T+ + + S V D Sbjct: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68 Query: 109 ISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSD 168 + S+ + + + ++ TGT+ G + + SV F S +I+SGS Sbjct: 69 VVISSDGQFALSGS--WDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS-SDNRQIVSGSR 125 Query: 169 DNTVAIFE-GPPFKFKSTFGEHTKFVHSVRYNPDGS--LFASTGGDGTIVLYNGVDGTKT 225 D T+ ++ K+ H+++V VR++P+ S + S G D + ++N + Sbjct: 126 DKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL- 184 Query: 226 GVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIED 285 ++ H+G + +T SPDG+ AS D +W++ K T+ G I Sbjct: 185 ------KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDII-- 236 Query: 286 QQLGIIWTKQALVSISANGFINFVNPELGSIDQVRY---------GHNKAITALSSSADG 336 L + L + + I + E I T+L+ SADG Sbjct: 237 NALCFSPNRYWLCAATG-PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADG 295 Query: 337 KTLFSADAEGHINSWDISTGI 357 +TLF+ + + W ++ G Sbjct: 296 QTLFAGYTDNLVRVWQVTIGT 316 Score = 138 bits (346), Expect = 9e-33, Method: Composition-based stats. Identities = 52/299 (17%), Positives = 108/299 (36%), Gaps = 55/299 (18%) Query: 319 VRYGHNKAITALSSSAD-GKTLFSADAEGHINSWDISTGISN----RVFPDVHATMITGI 373 GHN +T ++++ + SA + I W ++ +N + H+ ++ + Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 Query: 374 KTTSKGD-LFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYK 432 +S G + SWD L++ Sbjct: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTT------------------------------- 98 Query: 433 HIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPA 492 V + + VA S+D + + G +D + ++ G V+ H Sbjct: 99 ---------RRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSE 149 Query: 493 EITSVAFSNNGA--FLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVR 550 ++ V FS N + +V+ + V +++AN + HT + V+ SPD Sbjct: 150 WVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN---CKLKTNHIGHTGYLNTVTVSPDGSL 206 Query: 551 LATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 A+G D ++W++N+ H + G +N++ + + A +IK W++ Sbjct: 207 CASGGKDGQAMLWDLNEG-KHLYTLDGGDI---INALCFSPNRYWLCAATGPSIKIWDL 261 Score = 138 bits (346), Expect = 1e-32, Method: Composition-based stats. Identities = 56/316 (17%), Positives = 111/316 (35%), Gaps = 39/316 (12%) Query: 276 TIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNP-----ELGSIDQVRYGHNKAITAL 330 T+ Q ++S S + I G + GH+ ++ + Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 Query: 331 SSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHL 390 S+DG+ S +G + WD++TG + R F +++ ++ + + S D + Sbjct: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 Query: 391 KVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYN 450 K+ G + + ++ VS + + + I S G V + Sbjct: 130 KLWNTLGVCKYTVQDESHS-------EWVSC---VRFSPNSSNPIIVSCGWDKLVKVWNL 179 Query: 451 SSC---------------VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEIT 495 ++C V +S D A GG+D + ++ L+ + T+ I Sbjct: 180 ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK--HLYTLDGGDIIN 237 Query: 496 SVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTA------KVACVSWSPDNV 549 ++ FS N +L A + + + + T+ + ++WS D Sbjct: 238 ALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQ 296 Query: 550 RLATGSLDNSVIVWNM 565 L G DN V VW + Sbjct: 297 TLFAGYTDNLVRVWQV 312 Score = 115 bits (288), Expect = 5e-26, Method: Composition-based stats. Identities = 37/241 (15%), Positives = 78/241 (32%), Gaps = 8/241 (3%) Query: 34 QYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTH 93 + ++ + G+ T + H+ S SG +++W+T Sbjct: 82 SWDGTLRLWDLTTGTT--TRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCK 139 Query: 94 ILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSV 153 S V + + S V G ++ V+ N G +N+V Sbjct: 140 -YTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTV 198 Query: 154 DFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGT 213 P SG D +++ K T ++++ ++P+ + G + Sbjct: 199 TVSPDGSLC-ASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPNRYWLCAATG-PS 255 Query: 214 IVLYNGVDGTKTGVFEDD--SLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATL 271 I +++ + + S + A L WS DG + + D +++W V Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 Query: 272 K 272 Sbjct: 316 T 316 >2YNP-A nrPDB Length = 604 Score = 187 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 89/517 (17%), Positives = 168/517 (32%), Gaps = 48/517 (9%) Query: 48 SLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVK 107 L + ++ S + P+ + + G V +W+ T + +I V PV+ Sbjct: 2 KLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWN--YETQVEVRSIQVTETPVR 59 Query: 108 DISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGS 167 + + I + VF ++TG + + S+ P++P+ + SGS Sbjct: 60 AGKFIARKNWIIVGSDDFR--IRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVL-SGS 116 Query: 168 DDNTVAIFEG-PPFKFKSTFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKT 225 DD TV ++ + + TF H FV V +NP D S FAS D T+ +++ T Sbjct: 117 DDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPN 176 Query: 226 GVFEDDSLKNVAHSGSVFGLTWS--PDGTKIASASADKTIKIWNVATLKVEKTIPVGTRI 283 V + + PD + +AS D TIKIW+ T T+ Sbjct: 177 FTL------TTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSN 230 Query: 284 EDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGK--TLFS 341 + T ++S S +G + N +++ + +++ G+ + S Sbjct: 231 VSFAV-FHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIAS 289 Query: 342 ADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSW-------DDHLKVVP 394 + + V + +G K + D+FT D + Sbjct: 290 G-FDNGFTVLSLGNDEPTLSLDPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQ 348 Query: 395 AGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCV 454 G + S + V DG+ + + GK + Sbjct: 349 TKELGSVDVFPQSLAHSPNGRFVTVVGDGEYVIYTALA-WRNKAFGKCQDF--------- 398 Query: 455 ALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRK 514 D A+ + ++ YK + V+ +H A L+ Sbjct: 399 VWGPDSNSYALIDETGQIKYYK-NFKEVTSWSVPMHSAIDRLF-----SGALLGVKSDGF 452 Query: 515 VIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRL 551 V + N + + V WS + + Sbjct: 453 VYFFDWDNGTLVRRIDVNA------KDVIWSDNGELV 483 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 89/517 (17%), Positives = 171/517 (33%), Gaps = 53/517 (10%) Query: 95 LKTTIPVFSGPVKDISWDSESKRIAAV-GEGRERFGHVFLFDTGTSNGNLTGQARAMNSV 153 +K T S VK I + + GR ++ ++T ++ + + Sbjct: 5 IKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGR---VELWNYETQVEVRSIQVTETPVRAG 61 Query: 154 DFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGT 213 F + + II GSDD + +F + F H ++ S+ +P S D T Sbjct: 62 KFIARKNW-IIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLT 120 Query: 214 IVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP-DGTKIASASADKTIKIWNVATLK 272 + L+N + H V + ++P D + AS D+T+K+W++ Sbjct: 121 VKLWNWENNWALE------QTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQST 174 Query: 273 VEKTIPVGTRIEDQQLG--IIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITAL 330 T+ G + + K +++ S + I + + S GH ++ Sbjct: 175 PNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFA 234 Query: 331 SSSADGKTLFSADAEGHINSWDISTGISNRVF-PDVHATMITGIKTTSKGDLFTVSWDDH 389 + S +G + W+ ST + + + T + + +D+ Sbjct: 235 VFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNG 294 Query: 390 LKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACY-----KHIAIYSHGKLTE 444 V+ G S KL A ++D AV +L Sbjct: 295 FTVLSLGNDEPTLSLDPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKELGS 354 Query: 445 VPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGA 504 V + S +A S + +FV V G D + +Y + + + Sbjct: 355 VDVFPQS--LAHSPNGRFVTVVG-DGEYVIYTALAWRNKAF------GKCQDFVWGPDSN 405 Query: 505 FLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGS-----LDNS 559 D++ ++ Y NF+ + S H+A RL +G+ D Sbjct: 406 SYALIDETGQIKYYK---NFKEVTSWSVPMHSAI----------DRLFSGALLGVKSDGF 452 Query: 560 VIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIV 596 V ++ + + I A VIW + +V Sbjct: 453 VYFFDWDNGTLVRRIDVNA------KDVIWSDNGELV 483 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 43/218 (19%), Positives = 88/218 (40%), Gaps = 10/218 (4%) Query: 393 VPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSS 452 + S + ++P L G + + + + S +TE P+ Sbjct: 5 IKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQ-VTETPVRAG-- 61 Query: 453 CVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQS 512 K ++ VG D ++ V+ + HP I S+A ++++ Sbjct: 62 --KFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFE-AHPDYIRSIAVHPTKPYVLSGSDD 118 Query: 513 RKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVWNMNKPSDH 571 V ++ NN+ L T + H V CV+++P D A+G LD +V VW++ + + + Sbjct: 119 LTVKLWNWENNWALEQT--FEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPN 176 Query: 572 PIIIKGAH-AMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 + G ++ V+ ++ +++A D IK W+ Sbjct: 177 FTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWD 214 Score = 116 bits (291), Expect = 2e-26, Method: Composition-based stats. Identities = 73/436 (16%), Positives = 144/436 (33%), Gaps = 38/436 (8%) Query: 38 GTSVYTVPVGSLTDTEI---YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHI 94 G+ + + V + E + H P+ Y SG V++W+ Sbjct: 73 GSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENN-WA 131 Query: 95 LKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLT-GQARAMNSV 153 L+ T V ++++ + A G +R V+ T N LT GQ R +N V Sbjct: 132 LEQTFEGHEHFVMCVAFNPKDPSTFASG-CLDRTVKVWSLGQSTPNFTLTTGQERGVNYV 190 Query: 154 DF--KPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGD 211 D+ P +P+ +I+ SDD T+ I++ +T H V ++P + S D Sbjct: 191 DYYPLPDKPY-MITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSED 249 Query: 212 GTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTK-IASASADKTIKIWNVAT 270 GT+ ++N ++ + + P G K ++ D + ++ Sbjct: 250 GTLKIWNSSTYKVEKTLNVGLERS-------WCIATHPTGRKNYIASGFDNGFTVLSLGN 302 Query: 271 LKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAI--- 327 + ++ D ++W+ + S E D+ K + Sbjct: 303 DEPTLSL-------DPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKELGSV 355 Query: 328 ----TALSSSADGKTL-FSADAEGHINS---W-DISTGISNRVFPDVHATMITGIKTTSK 378 +L+ S +G+ + D E I + W + + G + I T + Sbjct: 356 DVFPQSLAHSPNGRFVTVVGDGEYVIYTALAWRNKAFGKCQDFVWGPDSNSYALIDETGQ 415 Query: 379 GDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIA--I 436 + + VP + + S D V + I Sbjct: 416 IKYYKNFKEVTSWSVPMHSAIDRLFSGALLGVKSDGFVYFFDWDNGTLVRRIDVNAKDVI 475 Query: 437 YSHGKLTEVPISYNSS 452 +S + ++ NS+ Sbjct: 476 WSDNGELVMIVNTNSN 491 Score = 104 bits (260), Expect = 9e-23, Method: Composition-based stats. Identities = 43/294 (14%), Positives = 94/294 (31%), Gaps = 17/294 (5%) Query: 315 SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIK 374 I + + + + + + G + W+ T + R + G Sbjct: 4 DIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKF 63 Query: 375 TTSKGDLFTVSWDDHLKVVP-AGGSGVDSSKAVANKLSS------QPLGLAVSADGDIAV 427 K + S D ++V G V +A + + S +P L+ S D + + Sbjct: 64 IARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKL 123 Query: 428 AACYKHIAIYSHGKLTEVPISYNSSCVALSN-DKQFVAVGGQDSKVHVYKLSGASVSEVK 486 + A+ T + CVA + D A G D V V+ L ++ + Sbjct: 124 WNWENNWALEQ----TFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTL 179 Query: 487 TIVHPAEITSVAFSN--NGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSW 544 T + V + + +++ + + + + H + V+ + Sbjct: 180 TTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTK---SCVATLEGHMSNVSFAVF 236 Query: 545 SPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSA 598 P + +GS D ++ +WN + + G + + + I S Sbjct: 237 HPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASG 290 Score = 78.4 bits (191), Expect = 8e-15, Method: Composition-based stats. Identities = 17/159 (10%), Positives = 50/159 (31%), Gaps = 4/159 (2%) Query: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATD 510 + + +V +V ++ + + + F +++ Sbjct: 16 VKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTET-PVRAGKFIARKNWIIVGS 74 Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 ++ ++ ++ + H + ++ P + +GS D +V +WN Sbjct: 75 DDFRIRVFNYNTGEKVVD---FEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWA 131 Query: 571 HPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 +G + + +T S D +K W++ Sbjct: 132 LEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSL 170 Score = 36.8 bits (83), Expect = 0.027, Method: Composition-based stats. Identities = 12/85 (14%), Positives = 30/85 (35%), Gaps = 2/85 (2%) Query: 524 FELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSS 583 +L +++ + +V + + P + T V +WN + I + + Sbjct: 1 MKLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRA 60 Query: 584 VNSVIWLNETTIVSAGQDSNIKFWN 608 + + I+ D I+ +N Sbjct: 61 GKFIA--RKNWIIVGSDDFRIRVFN 83 >5G04-R nrPDB Length = 499 Score = 185 bits (469), Expect = 4e-47, Method: Composition-based stats. Identities = 58/297 (19%), Positives = 109/297 (36%), Gaps = 22/297 (7%) Query: 65 AKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEG 124 S SG A + +V +W + + + + ++W E +A Sbjct: 190 VDWS-SGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247 Query: 125 RERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP-PFKFK 183 E ++ N+T + + S+ + + + SGS + + Sbjct: 248 AE--VQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHV 302 Query: 184 STFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVF 243 +T H++ V +R+ PDG AS G D + ++ G V H G+V Sbjct: 303 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV---PLQTFTQHQGAVK 359 Query: 244 GLTWSPDGTKIAS---ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSI 300 + W P + + + ++D+ I+IWNV + + + Q I+W+ I Sbjct: 360 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS----QVCSILWSPHYKELI 415 Query: 301 SANGFIN----FVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 S +GF + GH + +L+ S DG T+ SA A+ + W Sbjct: 416 SGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 Score = 152 bits (383), Expect = 5e-37, Method: Composition-based stats. Identities = 66/321 (20%), Positives = 111/321 (34%), Gaps = 32/321 (9%) Query: 5 SQTALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEH--SHQT 62 S P + L + +G+ + SVY S ++ Sbjct: 170 SLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYI 229 Query: 63 TVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVG 122 + G Y A G V++WD Q + T S V +SW+S I + G Sbjct: 230 SSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMT--SHSARVGSLSWNS---YILSSG 284 Query: 123 EGRERFGHVFLFDTGTSNG---NLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPP 179 R GH+ D + L+G ++ + + + P + SG +DN V ++ P Sbjct: 285 S---RSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGR-HLASGGNDNLVNVWPSAP 340 Query: 180 ----FKFKSTFGEHTKFVHSVRYNPDGSL-FASTG--GDGTIVLYNGVDGTKTGVFEDDS 232 + TF +H V +V + P S A+ G D I ++N G + Sbjct: 341 GEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVD--- 397 Query: 233 LKNVAHSGSVFGLTWSPDGTKIASAS--ADKTIKIWNVATLKVEKTIPVGTRIEDQQLGI 290 AHS V + WSP ++ S A + IW T+ + G L + Sbjct: 398 ----AHS-QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELK-GHTSRVLSLTM 451 Query: 291 IWTKQALVSISANGFINFVNP 311 + S +A+ + Sbjct: 452 SPDGATVASAAADETLRLWRC 472 Score = 109 bits (271), Expect = 4e-24, Method: Composition-based stats. Identities = 46/328 (14%), Positives = 112/328 (34%), Gaps = 57/328 (17%) Query: 290 IIWTKQALVSISANGFINFVNPELGSIDQVRYGHNK--AITALSSSADGKTLFSADAEGH 347 + W+ +++++ + + + G I Q+ I++++ +G L + Sbjct: 190 VDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE 249 Query: 348 INSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVA 407 + WD+ R + + + Sbjct: 250 VQLWDVQQQKRLR-----------------------------------------NMTSHS 268 Query: 408 NKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGG 467 ++ S + + G + + + + H T S + + D + +A GG Sbjct: 269 ARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGG 328 Query: 468 QDSKVHVYKL---SGASVSEVKTIVHPAEITSVAFSNNGAFLVA---TDQSRKVIPYSVA 521 D+ V+V+ G V H + +VA+ + ++A R + ++V Sbjct: 329 NDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC 388 Query: 522 NNFELAHTNSWTFHTAKVACVSWSPDNVRLATG--SLDNSVIVWNMNKPSDHPIIIKGAH 579 + L+ ++ ++V + WSP L +G N +++W P+ + H Sbjct: 389 SGACLSAVDA----HSQVCSILWSPHYKELISGHGFAQNQLVIW--KYPTMAKVAELKGH 442 Query: 580 AMSSVNSVIWLNETTIVSAGQDSNIKFW 607 ++ + + T+ SA D ++ W Sbjct: 443 TSRVLSLTMSPDGATVASAAADETLRLW 470 Score = 103 bits (255), Expect = 4e-22, Method: Composition-based stats. Identities = 44/210 (20%), Positives = 82/210 (39%), Gaps = 16/210 (7%) Query: 411 SSQPLGLAVSADGDIAVAACYKHIAIYSHGK------LTEVPISYNSSCVALSNDKQFVA 464 + L L + G++ A + ++S L S VA + ++A Sbjct: 183 NDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLA 242 Query: 465 VGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNF 524 VG ++V ++ + T H A + S+++ N L + +S + + V Sbjct: 243 VGTSSAEVQLWDVQQQKRLRNMT-SHSARVGSLSW--NSYILSSGSRSGHIHHHDVR--V 297 Query: 525 ELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVW-NMNKPSDHPIIIKGAHAMSS 583 H + + H+ +V + W+PD LA+G DN V VW + + + Sbjct: 298 AEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGA 357 Query: 584 VNSVIWLN--ETTIVSAG--QDSNIKFWNV 609 V +V W + + G D +I+ WNV Sbjct: 358 VKAVAWCPWQSNVLATGGGTSDRHIRIWNV 387 Score = 38.3 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 9/55 (16%), Positives = 16/55 (29%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDI 109 H+ + SP G AS +R+W + + S + Sbjct: 439 LKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSL 493 >4V7E-Bg nrPDB Length = 380 Score = 184 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 63/347 (18%), Positives = 126/347 (36%), Gaps = 33/347 (9%) Query: 31 DKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQ 90 +K G + + L HS + +P + S G + +W+ Sbjct: 38 EKYSKAQGRTAVSFNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNAL- 96 Query: 91 TTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTS-------NGNL 143 T I + V + ++ + +A G + +F + + L Sbjct: 97 -TSQKTHAIKLHCPWVMECAFAPNGQSVAC--GGLDSACSIFNLSSQADRDGNMPVSRVL 153 Query: 144 TGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTF-----GEHTKFVHSVRY 198 TG +S + P + R+I+GS D T +++ + S F HT V S+ Sbjct: 154 TGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSI 213 Query: 199 NP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASA 257 N + ++F S D T+ L++ + H G + + + PDG + + Sbjct: 214 NSLNANMFISGSCDTTVRLWDLR------ITSRAVRTYHGHEGDINSVKFFPDGQRFGTG 267 Query: 258 SADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW------TKQALVSISANGFINFVNP 311 S D T +++++ T + D +L I+ + + L + +NG + Sbjct: 268 SDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDT 327 Query: 312 ELGSI----DQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIS 354 L + ++ H I+ L S+DG L + + ++ W S Sbjct: 328 LLAEMVLNLGTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIWAFS 374 Score = 148 bits (374), Expect = 5e-36, Method: Composition-based stats. Identities = 55/324 (16%), Positives = 108/324 (33%), Gaps = 25/324 (7%) Query: 19 GTAVVLGNTPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASG 77 G L TP + I + V + T H +P+G A G Sbjct: 67 GKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPNGQSVACG 126 Query: 78 DVHGNVRIWDTTQTTH-----ILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVF 132 + I++ + + + G + + + G G ++ ++ Sbjct: 127 GLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSG-DQTCVLW 185 Query: 133 LFDTGTSNGNL-----TGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP-PFKFKSTF 186 TG +G + S+ ISGS D TV +++ + T+ Sbjct: 186 DVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTY 245 Query: 187 GEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLT 246 H ++SV++ PDG F + DGT L++ G + V+ + +N V + Sbjct: 246 HGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVA 305 Query: 247 WSPDGTKIASASADKTIKIWNVATLKVEK---TIPVGTRIEDQQLGIIWTKQALVSISAN 303 +S G + + ++ +W+ ++ T+ LG+ AL + S + Sbjct: 306 FSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSALCTGSWD 365 Query: 304 GFINFVNPELGSIDQVRYGHNKAI 327 + GH K + Sbjct: 366 KNLKIW---------AFSGHRKIV 380 Score = 140 bits (352), Expect = 2e-33, Method: Composition-based stats. Identities = 53/374 (14%), Positives = 115/374 (30%), Gaps = 55/374 (14%) Query: 170 NTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFE 229 T F T H+ V+S+ + P+ + S DG ++++N + KT + Sbjct: 46 RTAVSFNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIK 105 Query: 230 DDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLK------VEKTIPVGTRI 283 H V ++P+G +A D I+N+++ + G + Sbjct: 106 L-------HCPWVMECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKG 158 Query: 284 EDQQLGIIWTKQA-LVSISANGFINFVNPELGSIDQVR-----YGHNKAITALSSSA-DG 336 + ++ L++ S + + G + GH + +LS ++ + Sbjct: 159 YASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNA 218 Query: 337 KTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAG 396 S + + WD+ H I +K G F DD Sbjct: 219 NMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDD-------- 270 Query: 397 GSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVAL 456 L G + +Y+ + VA Sbjct: 271 ----------------GTCRLFDMRTGH--------QLQVYNREPDRNDNELPIVTSVAF 306 Query: 457 SNDKQFVAVGGQDSKVHVYKLSGASVSE---VKTIVHPAEITSVAFSNNGAFLVATDQSR 513 S + + G + +V+ A + H I+ + S++G+ L + Sbjct: 307 SISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSALCTGSWDK 366 Query: 514 KVIPYSVANNFELA 527 + ++ + + ++ Sbjct: 367 NLKIWAFSGHRKIV 380 Score = 121 bits (304), Expect = 6e-28, Method: Composition-based stats. Identities = 44/321 (13%), Positives = 92/321 (28%), Gaps = 24/321 (7%) Query: 310 NPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATM 369 NP + GH+ + +L + + + SA +G + W+ T +H Sbjct: 52 NPTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIK-LHCPW 110 Query: 370 ITGIKTTSKGDLFTVS-WDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSA------- 421 + G D + +++ + G A S Sbjct: 111 VMECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQE 170 Query: 422 --------DGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVAL-SNDKQFVAVGGQDSKV 472 D + I G + + +++ S + G D+ V Sbjct: 171 TRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTV 230 Query: 473 HVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSW 532 ++ L S + H +I SV F +G + + +L N Sbjct: 231 RLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNRE 290 Query: 533 TFHTA----KVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAH-AMSSVNSV 587 V V++S L G + VW+ + + ++ + Sbjct: 291 PDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCL 350 Query: 588 -IWLNETTIVSAGQDSNIKFW 607 + + + + + D N+K W Sbjct: 351 GLSSDGSALCTGSWDKNLKIW 371 Score = 80.3 bits (196), Expect = 3e-15, Method: Composition-based stats. Identities = 37/246 (15%), Positives = 82/246 (33%), Gaps = 16/246 (6%) Query: 374 KTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKH 433 K + VS++ V G + + ++ S DG + V + Sbjct: 39 KYSKAQGRTAVSFNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIV----WN 94 Query: 434 IAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLS------GASVSEVKT 487 ++ + C A + + Q VA GG DS ++ LS G Sbjct: 95 ALTSQKTHAIKLHCPWVMEC-AFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVL 153 Query: 488 IVHPAEITSVAFSNN-GAFLVATDQSRKVIPYSVANN--FELAHTNSWTFHTAKVACVSW 544 H +S + + L+ + + + V + + + HTA V +S Sbjct: 154 TGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSI 213 Query: 545 SP-DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSN 603 + + +GS D +V +W++ + + + H + + + + D Sbjct: 214 NSLNANMFISGSCDTTVRLWDL-RITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGT 272 Query: 604 IKFWNV 609 + +++ Sbjct: 273 CRLFDM 278 >6EMK-B nrPDB Length = 303 Score = 182 bits (462), Expect = 3e-46, Method: Composition-based stats. Identities = 52/303 (17%), Positives = 111/303 (36%), Gaps = 17/303 (5%) Query: 74 CASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFL 133 S +R W+ T + TI V + ++ K +A G R + Sbjct: 5 LVSAGYDHTIRFWEAL--TGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 Query: 134 FDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFV 193 + + G + SV F+ + +++ S+D T+ +++ + H V Sbjct: 63 TNP-NPVASFEGHRGNVTSVSFQQDNRW-MVTSSEDGTIKVWDVRSPSIPRNYK-HNAPV 119 Query: 194 HSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTK 253 + V +P+ S DG I +++ + T + S+ L+ + DG+ Sbjct: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPED------DTSLQSLSMASDGSM 173 Query: 254 IASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW-----TKQALVSISANGFINF 308 +A+A+ +W + + T+ I + L + SA+ Sbjct: 174 LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARV 233 Query: 309 VNPELG-SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHA 367 + + ++ GH + + + SAD L +A ++ ++ WD+ST R + H Sbjct: 234 WSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHK 293 Query: 368 TMI 370 + Sbjct: 294 GAV 296 Score = 122 bits (306), Expect = 4e-28, Method: Composition-based stats. Identities = 58/340 (17%), Positives = 119/340 (35%), Gaps = 55/340 (16%) Query: 253 KIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPE 312 + SA D TI+ W T +TI + + +L I K+ L + + + + Sbjct: 4 ILVSAGYDHTIRFWEALTGVCSRTIQ-HSDSQVNRLEITNDKKLLATAG-HQNVRLYDIR 61 Query: 313 LGSID--QVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMI 370 + + GH +T++S D + + ++ +G I WD+ + R + H + Sbjct: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK--HNAPV 119 Query: 371 TGIKTTSK-GDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAA 429 + G+L + D ++++ G + + S Q L +A Sbjct: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMA----------- 168 Query: 430 CYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGAS-----VSE 484 +D +A +V+++ + Sbjct: 169 ----------------------------SDGSMLAAANTKGNCYVWEMPNHTDASHLKPV 200 Query: 485 VKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSW 544 K H IT + S++ L +S+ ++F+L T H V ++ Sbjct: 201 TKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETT--LDGHQRWVWDCAF 258 Query: 545 SPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSV 584 S D+ L T S D+ V +W+++ + + G H +V Sbjct: 259 SADSAYLVTASSDHYVRLWDLS--TREIVRQYGGHHKGAV 296 Score = 112 bits (280), Expect = 4e-25, Method: Composition-based stats. Identities = 44/285 (15%), Positives = 104/285 (36%), Gaps = 22/285 (7%) Query: 338 TLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVV---- 393 L SA + I W+ TG+ +R + + ++ T+ L + ++++ Sbjct: 4 ILVSAGYDHTIRFWEALTGVCSRTI-QHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 Query: 394 -----PAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPIS 448 A G + + + S DG I V ++ V Sbjct: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPV--- 119 Query: 449 YNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVA 508 + V + ++ + +D + ++ L + T + S++ +++G+ L A Sbjct: 120 ---NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAA 176 Query: 509 TDQSRKVIPYSVANNFELAHTN---SWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM 565 + + + N+ + +H + H+ + + S D LAT S D++ VW++ Sbjct: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 Query: 566 NKPSDHPIIIKGAHAMSSVNSVIWL-NETTIVSAGQDSNIKFWNV 609 + + G V + + +V+A D ++ W++ Sbjct: 237 DDDFKLETTLDG--HQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 >5OQL-J nrPDB Length = 912 Score = 182 bits (461), Expect = 4e-46, Method: Composition-based stats. Identities = 112/683 (16%), Positives = 220/683 (32%), Gaps = 128/683 (18%) Query: 24 LGNTPAGDKIQYCNGT---SVYTVPVGSLTDTEIYTE------HSHQTTVAKTSPSGYYC 74 L TP+G + C+ + +Y++ + D+ T H+ V + Sbjct: 67 LTITPSGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLL 126 Query: 75 ASGDVHGNVRIWDT--------TQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGR- 125 A+G G ++IWD +L + + F V S S K +G+ Sbjct: 127 ATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQN 186 Query: 126 ---------------ERFGHVFLFDTGTS---------NGNLTGQARAMNSVDFKPSRPF 161 + G + +FD + + + P + Sbjct: 187 DDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQH- 245 Query: 162 RIISGSDDNTVAIFEGPPFKFKST-FGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGV 220 ++SGS D T+ ++ ++ T H + SV + +G S G G + +++ Sbjct: 246 ALLSGSRDKTMTLWLWRDGIWQGTPMLRHE-LLESVGFLNEGKWMYSAGTSGVLRIWDTT 304 Query: 221 DGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT---------- 270 + +D + A +V P+ + I A AD T+ ++ V + Sbjct: 305 THHEITKKQDAKSEGEAILSAVSL----PERSLILCAQADFTLVLYRVPSPADVVSSSEG 360 Query: 271 --LKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPEL--------------- 313 L+ + I I+ + + + + I V+ + Sbjct: 361 ILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGS 420 Query: 314 --GSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMIT 371 G + GH + +L G + S + W + ++ V Sbjct: 421 YFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFT---- 476 Query: 372 GIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACY 431 G L +V KVVP S +A N L P L +S D V Sbjct: 477 -------GHLESVGAVALPKVVPPANS-----EAFKNPLDHPPAFL-ISGSQDRFVQKRD 523 Query: 432 KHIAIYSHGK----LTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKT 487 + GK L + + + + +S + + A QD V ++ + V + Sbjct: 524 IPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGIL- 582 Query: 488 IVHPAEITSVAFSN-------------NGAFLV-ATDQSRKVIPYSVANNFELAHTNSWT 533 H + +V F+ +G +V + + +++++ ++ Sbjct: 583 RGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSD---YTCIRTFE 639 Query: 534 FHTAKVACVSW---SPDNV------RLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSV 584 H+ V V W S D+ + A+ D V VW+ N + + ++ Sbjct: 640 GHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTL 699 Query: 585 NSVIWLNETTIVSAGQDSNIKFW 607 + + SAG DS + FW Sbjct: 700 --AVHSKTNILASAGSDSKVTFW 720 Score = 155 bits (391), Expect = 5e-38, Method: Composition-based stats. Identities = 89/636 (13%), Positives = 186/636 (29%), Gaps = 123/636 (19%) Query: 91 TTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRER------FGHVFLFDTGTSNGNLT 144 T I P+ ++ + + T Sbjct: 49 NTGKRLAEIQGDGEPISTLTITPSGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTK 108 Query: 145 GQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRY------ 198 A + + + + +G+ D + I++ T + V ++ + Sbjct: 109 PHATPVVVLAVDRTSTL-LATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVT 167 Query: 199 ------------------NPDGSLFAS------TGGDGTIVLYNGVDGTKTGVFEDDSLK 234 N D AS DG I +++ T T V+ D K Sbjct: 168 AESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRK 227 Query: 235 NVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK 294 AH +V + +SP+ + S S DKT+ +W + T P+ + +G + Sbjct: 228 KEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGT-PMLRHELLESVGFLNEG 286 Query: 295 QALVSISANGFINFVNPELGSIDQVRYGHNKA---ITALSSSADGKTLFSADAEGHINSW 351 + + S +G + + + I + S + + A A+ + + Sbjct: 287 KWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLVLY 346 Query: 352 DISTG------------ISNRVFPDVHATMITGIKTTSKGDLFTVSW---DDHLKVVPAG 396 + + R H ++ + ++ D + V Sbjct: 347 RVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDA 406 Query: 397 GSGVDSSKAV-------------------ANKLSSQPLGLAVSADGDIAVAACYK----- 432 + + + L G +++ A ++ Sbjct: 407 QAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPAN 466 Query: 433 ---------HIAIYSHGKLTEVPISYNSSCVALSNDKQ----FVAVGGQDSKVHVYKL-- 477 + S G + + ++ A N F+ G QD V + Sbjct: 467 NSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPR 526 Query: 478 ---SGASV-SEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWT 533 G + S ++ + H +I ++ S NG + Q + V + V +L Sbjct: 527 QLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVKIWDVE---KLEVQGILR 583 Query: 534 FHTAKVACVSWSPDNV--------------RLATGSLDNSVIVWNMNKPSDHPIIIKGAH 579 H V V ++P N + TGS D ++ +WN++ + +H Sbjct: 584 GHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSH 643 Query: 580 AMSSVNSVIWLNETTI-------VSAGQDSNIKFWN 608 + V + + +I SAG D+ +K W+ Sbjct: 644 NVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWD 679 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 56/304 (18%), Positives = 103/304 (33%), Gaps = 61/304 (20%) Query: 99 IPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFD----TGTSNGNLTGQARAMNSVD 154 + V + D IA+ ++ ++ D + T TG ++ +V Sbjct: 429 LKGHEDIVMSLDVDWSGHWIASGS--KDNTARLWRVDPANNSYTCYAVFTGHLESVGAVA 486 Query: 155 F-----------------KPSRPFRIISGSDDNTVAIFEGP-----PFKFKSTFG--EHT 190 P P +ISGS D V + P K S+ H Sbjct: 487 LPKVVPPANSEAFKNPLDHP--PAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHD 544 Query: 191 KFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD 250 K ++++ +P+G LFAS D T+ +++ G+ H V+ + ++P Sbjct: 545 KDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILR-------GHKRGVWTVRFAPL 597 Query: 251 GT--------------KIASASADKTIKIWNVATLKVEKTIPVGTR--------IEDQQL 288 T + + S DKTIK+WN++ +T + + Sbjct: 598 NTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDD 657 Query: 289 GIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHI 348 I TK S A+ + + G + H + L+ + L SA ++ + Sbjct: 658 SITKTKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTNILASAGSDSKV 717 Query: 349 NSWD 352 W Sbjct: 718 TFWR 721 Score = 141 bits (356), Expect = 6e-34, Method: Composition-based stats. Identities = 73/409 (17%), Positives = 132/409 (32%), Gaps = 72/409 (17%) Query: 56 TEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTT----------IPVFSGP 105 A + P + ++ ++ ++ I Sbjct: 316 KSEGEAILSAVSLPERSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDE 375 Query: 106 VKDISW---DSESKRIAAVGEG----RERFGHVFLFDTGTS---------NGNLTGQARA 149 + D+++ D IA E + + D L G Sbjct: 376 ILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDI 435 Query: 150 MNSVDFKPSRPFRIISGSDDNTVAIFEG----PPFKFKSTFGEHTKFVHSVRY------- 198 + S+D S + I SGS DNT ++ + + F H + V +V Sbjct: 436 VMSLDVDWSGHW-IASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPA 494 Query: 199 ----------NPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 +P + S D + + + G SL+ +AH + L S Sbjct: 495 NSEAFKNPLDHP-PAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDIS 553 Query: 249 PDGTKIASASADKTIKIWNVATLKVE-------------KTIPVGTRIEDQQLGIIWTKQ 295 P+G ASAS DKT+KIW+V L+V+ + P+ T + + G + + Sbjct: 554 PNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRG 613 Query: 296 ALVSISANGFINFVNPELGSIDQVRYGHNKAITA---LSSSADGKT------LFSADAEG 346 +++ S + I N + + GH+ + L S D SA A+ Sbjct: 614 VVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADT 673 Query: 347 HINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPA 395 + WD +TG + D H + + SK ++ + D Sbjct: 674 LVKVWDANTGETECTL-DNHEDRLWTLAVHSKTNILASAGSDSKVTFWR 721 Score = 139 bits (349), Expect = 4e-33, Method: Composition-based stats. Identities = 64/346 (18%), Positives = 110/346 (31%), Gaps = 62/346 (17%) Query: 17 ARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIY-------TEHSHQTTVAKTSP 69 + + + +I Y+ + H Sbjct: 384 PDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDW 443 Query: 70 SGYYCASGDVHGNVRIW--DTTQTTHILKTTIPVFSGPVKDIS----------------W 111 SG++ ASG R+W D ++ V ++ Sbjct: 444 SGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPL 503 Query: 112 DSESKRIAAVGEGR---ERFGHVFLFDTGTSNGNLT--GQARAMNSVDFKPSRPFRIISG 166 D + + + R +R L G +L + +N++D P+ S Sbjct: 504 DHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKL-FASA 562 Query: 167 SDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNP---------DGS-----LFASTGGDG 212 S D TV I++ + + H + V +VR+ P GS + + GD Sbjct: 563 SQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDK 622 Query: 213 TIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW---SPDGT------KIASASADKTI 263 TI L+N D T FE HS +V + W S D + + ASA AD + Sbjct: 623 TIKLWNLSDYTCIRTFE-------GHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLV 675 Query: 264 KIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFV 309 K+W+ T + E T+ L + L S ++ + F Sbjct: 676 KVWDANTGETECTLDNHED-RLWTLAVHSKTNILASAGSDSKVTFW 720 Score = 114 bits (286), Expect = 8e-26, Method: Composition-based stats. Identities = 77/546 (14%), Positives = 154/546 (28%), Gaps = 96/546 (17%) Query: 158 SRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLY 217 + + S +N + E K + + + ++ P GS T+ +Y Sbjct: 30 NGARILASTLGENAILT-ELNTGKRLAEIQGDGEPISTLTITPSGSHLIVCSRSLTMRIY 88 Query: 218 NGVDGTKTGVFEDDSLKNV-AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKT 276 + E ++ H+ V L T +A+ +AD IKIW++ V T Sbjct: 89 SLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHT 148 Query: 277 I-----------------------------PVGTRIEDQQLGIIWTKQALVSISANGFIN 307 + + ++ I ++ L + +G I Sbjct: 149 VSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIR 208 Query: 308 FVN-------PELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNR 360 + P + + H + ++ S + L S + + W GI + Sbjct: 209 IFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGI-WQ 267 Query: 361 VFPDVHATMITGIKTTSKGDLFTVS--------WDDHLKVVPAGGSGVDSSKAVANKLSS 412 P + ++ + ++G + WD S S Sbjct: 268 GTPMLRHELLESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVS 327 Query: 413 QP---LGLAVSADGDIAVAACYKHIAIYSHGK------LTEVPISYNS--SCVALSNDKQ 461 P L L AD + + + S + + +++ + D+ Sbjct: 328 LPERSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQS 387 Query: 462 FVAVGGQDSKVHVYKLSGASVSE----------------VKTIVHPAEITSVAFSNNGAF 505 +A+ + + + A H + S+ +G + Sbjct: 388 MMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHW 447 Query: 506 LVATDQSRKVIPYSVA-NNFELAHTNSWTFHTAKVACVS----WSPDNVR---------- 550 + + + + V N +T H V V+ P N Sbjct: 448 IASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPP 507 Query: 551 --LATGSLDNSVIVWNM-----NKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSN 603 L +GS D V ++ + + AH I N SA QD Sbjct: 508 AFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKT 567 Query: 604 IKFWNV 609 +K W+V Sbjct: 568 VKIWDV 573 Score = 103 bits (257), Expect = 2e-22, Method: Composition-based stats. Identities = 27/192 (14%), Positives = 59/192 (30%), Gaps = 22/192 (11%) Query: 47 GSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPV 106 G LT + H SP+G AS V+IWD ++ + V Sbjct: 532 GKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVKIWDVE--KLEVQGILRGHKRGV 589 Query: 107 KDISWDSESKRIAAVGEGR------------ERFGHVFLFDTGTSNGNLTGQARAMNSVD 154 + + + + +G ++ ++ T G + + V Sbjct: 590 WTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVV 649 Query: 155 FK--------PSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFA 206 + + S D V +++ + + T H + ++ + ++ A Sbjct: 650 WLHISRDDSITKTKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTNILA 709 Query: 207 STGGDGTIVLYN 218 S G D + + Sbjct: 710 SAGSDSKVTFWR 721 >4GGA-A nrPDB Length = 420 Score = 182 bits (461), Expect = 4e-46, Method: Composition-based stats. Identities = 58/297 (19%), Positives = 109/297 (36%), Gaps = 22/297 (7%) Query: 65 AKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEG 124 S SG A + +V +W + + + + ++W E +A Sbjct: 111 VDWS-SGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 168 Query: 125 RERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP-PFKFK 183 E ++ N+T + + S+ + + + SGS + + Sbjct: 169 AE--VQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHV 223 Query: 184 STFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVF 243 +T H++ V +R+ PDG AS G D + ++ G V H G+V Sbjct: 224 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV---PLQTFTQHQGAVK 280 Query: 244 GLTWSPDGTKIAS---ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSI 300 + W P + + + ++D+ I+IWNV + + + Q I+W+ I Sbjct: 281 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS----QVCSILWSPHYKELI 336 Query: 301 SANGFIN----FVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 S +GF + GH + +L+ S DG T+ SA A+ + W Sbjct: 337 SGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 393 Score = 149 bits (375), Expect = 4e-36, Method: Composition-based stats. Identities = 60/292 (20%), Positives = 104/292 (35%), Gaps = 30/292 (10%) Query: 32 KIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQT 91 + N +++ G + + + G Y A G V++WD Q Sbjct: 120 AVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQ 179 Query: 92 THILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNG---NLTGQAR 148 + T S V +SW+S I + G R GH+ D + L+G ++ Sbjct: 180 KRLRNMT--SHSARVGSLSWNS---YILSSGS---RSGHIHHHDVRVAEHHVATLSGHSQ 231 Query: 149 AMNSVDFKPSRPFRIISGSDDNTVAIFEGPP----FKFKSTFGEHTKFVHSVRYNPDGSL 204 + + + P + SG +DN V ++ P + TF +H V +V + P S Sbjct: 232 EVCGLRWAPDGR-HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 290 Query: 205 -FASTG--GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASAS--A 259 A+ G D I ++N G + AHS V + WSP ++ S A Sbjct: 291 VLATGGGTSDRHIRIWNVCSGACLSAVD-------AHS-QVCSILWSPHYKELISGHGFA 342 Query: 260 DKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNP 311 + IW T+ + G L + + S +A+ + Sbjct: 343 QNQLVIWKYPTMAKVAELK-GHTSRVLSLTMSPDGATVASAAADETLRLWRC 393 Score = 106 bits (265), Expect = 2e-23, Method: Composition-based stats. Identities = 46/328 (14%), Positives = 112/328 (34%), Gaps = 57/328 (17%) Query: 290 IIWTKQALVSISANGFINFVNPELGSIDQVRYGHNK--AITALSSSADGKTLFSADAEGH 347 + W+ +++++ + + + G I Q+ I++++ +G L + Sbjct: 111 VDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE 170 Query: 348 INSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVA 407 + WD+ R + + + Sbjct: 171 VQLWDVQQQKRLR-----------------------------------------NMTSHS 189 Query: 408 NKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGG 467 ++ S + + G + + + + H T S + + D + +A GG Sbjct: 190 ARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGG 249 Query: 468 QDSKVHVYKL---SGASVSEVKTIVHPAEITSVAFSNNGAFLVA---TDQSRKVIPYSVA 521 D+ V+V+ G V H + +VA+ + ++A R + ++V Sbjct: 250 NDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC 309 Query: 522 NNFELAHTNSWTFHTAKVACVSWSPDNVRLATG--SLDNSVIVWNMNKPSDHPIIIKGAH 579 + L+ ++ ++V + WSP L +G N +++W P+ + H Sbjct: 310 SGACLSAVDA----HSQVCSILWSPHYKELISGHGFAQNQLVIW--KYPTMAKVAELKGH 363 Query: 580 AMSSVNSVIWLNETTIVSAGQDSNIKFW 607 ++ + + T+ SA D ++ W Sbjct: 364 TSRVLSLTMSPDGATVASAAADETLRLW 391 Score = 101 bits (250), Expect = 1e-21, Method: Composition-based stats. Identities = 44/210 (20%), Positives = 82/210 (39%), Gaps = 16/210 (7%) Query: 411 SSQPLGLAVSADGDIAVAACYKHIAIYSHGK------LTEVPISYNSSCVALSNDKQFVA 464 + L L + G++ A + ++S L S VA + ++A Sbjct: 104 NDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLA 163 Query: 465 VGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNF 524 VG ++V ++ + T H A + S+++ N L + +S + + V Sbjct: 164 VGTSSAEVQLWDVQQQKRLRNMT-SHSARVGSLSW--NSYILSSGSRSGHIHHHDVR--V 218 Query: 525 ELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVW-NMNKPSDHPIIIKGAHAMSS 583 H + + H+ +V + W+PD LA+G DN V VW + + + Sbjct: 219 AEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGA 278 Query: 584 VNSVIWLN--ETTIVSAG--QDSNIKFWNV 609 V +V W + + G D +I+ WNV Sbjct: 279 VKAVAWCPWQSNVLATGGGTSDRHIRIWNV 308 Score = 37.9 bits (86), Expect = 0.014, Method: Composition-based stats. Identities = 9/55 (16%), Positives = 16/55 (29%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDI 109 H+ + SP G AS +R+W + + S + Sbjct: 360 LKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSL 414 >5WYJ-BC nrPDB Length = 817 Score = 181 bits (460), Expect = 6e-46, Method: Composition-based stats. Identities = 58/270 (21%), Positives = 112/270 (41%), Gaps = 28/270 (10%) Query: 100 PVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSN----GNLTGQARAMNSVDF 155 + + + IA ++ V+ ++ + G + A+ +V Sbjct: 385 EGHEDLLNSLDATEDGLWIATAS--KDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGL 442 Query: 156 ----KPSRPFRIISGSDDNTVAIFEGPPFKF----------KSTFGEHTKFVHSVRYNPD 201 P +++ S+D T+ + P + T H K ++++ +P+ Sbjct: 443 PNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPN 502 Query: 202 GSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADK 261 S+FA+ D T ++N +G + H ++ +++ +A++S DK Sbjct: 503 DSIFATASYDKTCKIWNLENGELEATLAN-------HKRGLWDVSFCQYDKLLATSSGDK 555 Query: 262 TIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRY 321 T+KIW++ T V KT+ G Q+ I ++ L+S A+G I + G + Sbjct: 556 TVKIWSLDTFSVMKTLE-GHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTLD 614 Query: 322 GHNKAITALSSSADGKTLFSADAEGHINSW 351 GHN + ALS+ DG + SADA+G W Sbjct: 615 GHNNRLWALSTMNDGDMIVSADADGVFQFW 644 Score = 163 bits (413), Expect = 2e-40, Method: Composition-based stats. Identities = 93/587 (15%), Positives = 188/587 (32%), Gaps = 69/587 (11%) Query: 53 EIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWD 112 +I E + T K +P G Y ++I+ + I D Sbjct: 55 KISNEDEQEITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKISS-----PSYILD 109 Query: 113 SESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDF---KPSRPFRIISGSDD 169 ++S G + V + G + G ++S+ F S+ + + SG + Sbjct: 110 ADSTSTLLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTN 169 Query: 170 NTVAIFEGPPFKFKSTFGEHTKFVHSVRY--NPDGS----LFASTGGDGTIVLYNGVDGT 223 V +++ K T EHT V + PD S G D I L++ Sbjct: 170 GMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKK 229 Query: 224 KTGVFEDDSLKNVAHSGSVFGLTWSPDG---TKIASASADKTIKIWNVATLKVEKTI--P 278 K + + + V + DG I +A D ++ + + V K P Sbjct: 230 KCKLLKTLPVNQ-----QVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKP 284 Query: 279 VGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKT 338 + L I+ Q + +S + + +N E I ++SS G Sbjct: 285 IEELFIIGVLPILSNSQMFLVLS-DQTLQLINVEED-----LKNDEDTI-QVTSSIAGNH 337 Query: 339 LFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTV-SWDDHLKVVPAGG 397 AD + + + + V +P Sbjct: 338 GIIADM----------------RYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDV 381 Query: 398 SGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALS 457 + + + N L + GL ++ A +++ + I ++++ A+ Sbjct: 382 EIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVG 441 Query: 458 NDK-------QFVAVGGQDSKVHVY---------KLSGASVSEVKTIVHPAEITSVAFSN 501 +F+ D + + + VSE H +I +++ S Sbjct: 442 LPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSP 501 Query: 502 NGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVI 561 N + + +++ N + H + VS+ + LAT S D +V Sbjct: 502 NDSIFATASYDKTCKIWNLENG---ELEATLANHKRGLWDVSFCQYDKLLATSSGDKTVK 558 Query: 562 VWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 +W+++ S + +A+ + + + ++S G D IK W+ Sbjct: 559 IWSLDTFSVMKTLEGHTNAVQRCSFI--NKQKQLISCGADGLIKIWD 603 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 82/585 (14%), Positives = 191/585 (32%), Gaps = 69/585 (11%) Query: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQT-THILKTTIPVFSGPVKDISWDSESK 116 ++ + VA S +G A+ + + I D T IL + + + + Sbjct: 16 YAGSSAVATVSENGKILATPVLD-EINIIDLTPGSRKILHKISNEDEQEITALKLTPDGQ 74 Query: 117 RIAAVGEGRERFGHVFLFDTGTSNGNLT-GQARAMNSVDFKPSRPFRIISGSDDNTVAIF 175 + V + + +F TG ++ + D S + G D ++ + Sbjct: 75 YLTYVSQAQ--LLKIFHLKTGKVVRSMKISSPSYILDAD---STSTLLAVGGTDGSIIVV 129 Query: 176 EGPPFKFKSTFGEHTKFVHSVRYNPDGS----LFASTGGDGTIVLYNGVDGTKTGVFEDD 231 + +F H + S+++ + L AS +G + +++ V ++ Sbjct: 130 DIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQE- 188 Query: 232 SLKNVAHSGSVFGLTWS--PDGT----KIASASADKTIKIWNVA-TLKVEKTIPVGTRIE 284 H+ +V GL PD + S D I +W+ K + + + Sbjct: 189 ------HTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQ 242 Query: 285 DQQLGIIWT---KQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFS 341 + G + K+ + + + ++ E GS+ + + + + + S Sbjct: 243 VESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVLP----ILS 298 Query: 342 ADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVD 401 + + + + ++ + +K T S + ++ Sbjct: 299 NS-----QMFLVLSDQTLQLI-----NVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGP 348 Query: 402 SSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQ 461 +A +S L + D A+ + IY + + + D Sbjct: 349 ELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIY-------EGHEDLLNSLDATEDGL 401 Query: 462 FVAVGGQDSKVHVYKLSGASVS---EVKTIVHPAEITSVAFSNN------GAFLVATDQS 512 ++A +D+ V++ + S K I H A +T+V N FL+ Sbjct: 402 WIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGL-PNIVSKGYPEFLLTASND 460 Query: 513 RKVIPY-------SVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM 565 + + S+ + H + +S SP++ AT S D + +WN+ Sbjct: 461 LTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNL 520 Query: 566 NKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNVP 610 + + V+ + + + ++ D +K W++ Sbjct: 521 ENGELEATLANHKRGLWDVSFCQY--DKLLATSSGDKTVKIWSLD 563 Score = 150 bits (377), Expect = 3e-36, Method: Composition-based stats. Identities = 48/307 (15%), Positives = 98/307 (31%), Gaps = 27/307 (8%) Query: 18 RGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASG 77 + N+P+ I + + D EIY H + G + A+ Sbjct: 350 LNKLALATNSPSLRIIPVPDLSG---PEASLPLDVEIYEGHEDLLNSLDATEDGLWIATA 406 Query: 78 DVHGNVRIW--DTTQTTHILKTTIPVFSGPVKDISW-----DSESKRIAAVGEGRERFGH 130 +W + + S V + + + Sbjct: 407 SKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKW 466 Query: 131 VFLFDTGT--------SNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKF 182 + T + S + +N++ P+ + S D T I+ + Sbjct: 467 IIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSI-FATASYDKTCKIWNLENGEL 525 Query: 183 KSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSV 242 ++T H + + V + L A++ GD T+ +++ + E H+ +V Sbjct: 526 EATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLE-------GHTNAV 578 Query: 243 FGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISA 302 ++ ++ S AD IKIW+ ++ + KT+ G L + +VS A Sbjct: 579 QRCSFINKQKQLISCGADGLIKIWDCSSGECLKTLD-GHNNRLWALSTMNDGDMIVSADA 637 Query: 303 NGFINFV 309 +G F Sbjct: 638 DGVFQFW 644 Score = 127 bits (318), Expect = 2e-29, Method: Composition-based stats. Identities = 61/403 (15%), Positives = 131/403 (32%), Gaps = 39/403 (9%) Query: 59 SHQTTVAKTSPSG---YYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPV-KDISWDSE 114 + Q G + ++ D+ + + +T P+ + + S Sbjct: 240 NQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVLPILSN 299 Query: 115 SKRIAAVGEGRERFGHV-----FLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDD 169 S+ + + + +V DT ++ G + + + ++ ++ Sbjct: 300 SQMFLVLSDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNS 359 Query: 170 NTVAI-----FEGPPFKF---KSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVD 221 ++ I GP + H ++S+ DG A+ D T +++ + Sbjct: 360 PSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNE 419 Query: 222 GTKTGVFEDDSLKNVAHSGSVFGLTWSPD------GTKIASASADKTIKIW--------- 266 + D K + HS +V + P+ + +AS D TIK W Sbjct: 420 NSCK---FDIYAKYIGHSAAVTAVGL-PNIVSKGYPEFLLTASNDLTIKKWIIPKPTASM 475 Query: 267 NVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKA 326 +V +KV + + L + + S + N E G ++ H + Sbjct: 476 DVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRG 535 Query: 327 ITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSW 386 + +S K L ++ + + W + T + H + +K Sbjct: 536 LWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEG-HTNAVQRCSFINKQKQLISCG 594 Query: 387 DDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAA 429 D L + SG + K + + L+ DGD+ V+A Sbjct: 595 ADGLIKIWDCSSG-ECLKTLDGHNNRL-WALSTMNDGDMIVSA 635 Score = 46.8 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 14/118 (11%), Positives = 35/118 (29%), Gaps = 4/118 (3%) Query: 8 ALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAK 66 L +L RG + + +G + + + + + H++ Sbjct: 524 ELEATLANHKRGL-WDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCS 582 Query: 67 TSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEG 124 S G ++IWD + T+ + + +S ++ I + Sbjct: 583 FINKQKQLISCGADGLIKIWDCSSGE--CLKTLDGHNNRLWALSTMNDGDMIVSADAD 638 Score = 46.8 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 43/359 (11%), Positives = 97/359 (27%), Gaps = 60/359 (16%) Query: 267 NVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGS---IDQVRYGH 323 ++ T ++ + + L + + IN ++ GS + ++ Sbjct: 2 DLKTSYKGISLNPIYAGSSAVATVSENGKILATPVLDE-INIIDLTPGSRKILHKISNED 60 Query: 324 NKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFT 383 + ITAL + DG+ L + + + TG R Sbjct: 61 EQEITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMK-------------------- 100 Query: 384 VSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSH---- 439 + S + + S+ L DG I V +S Sbjct: 101 ----------------ISSPSYILDADSTSTLLAVGGTDGSIIVVDIENGYITHSFKGHG 144 Query: 440 GKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAF 499 G ++ + + +A G + V V+ L H + + + Sbjct: 145 GTISSLKFYGQLNSKIW-----LLASGDTNGMVKVWDLVKRKCLHTL-QEHTSAVRGLDI 198 Query: 500 --SNNGAF----LVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDN---VR 550 + L++ + + + N + +V + D Sbjct: 199 IEVPDNDEPSLNLLSGGRDDIINLWDF-NMKKKCKLLKTLPVNQQVESCGFLKDGDGKRI 257 Query: 551 LATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 + T D + + S K + + + L+ + + D ++ NV Sbjct: 258 IYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVLPILSNSQMFLVLSDQTLQLINV 316 >5LCW-Q nrPDB Length = 374 Score = 180 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 58/297 (19%), Positives = 109/297 (36%), Gaps = 22/297 (7%) Query: 65 AKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEG 124 S SG A + +V +W + + + + ++W E +A Sbjct: 65 VDWS-SGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 122 Query: 125 RERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP-PFKFK 183 E ++ N+T + + S+ + + + SGS + + Sbjct: 123 AE--VQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHV 177 Query: 184 STFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVF 243 +T H++ V +R+ PDG AS G D + ++ G V H G+V Sbjct: 178 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV---PLQTFTQHQGAVK 234 Query: 244 GLTWSPDGTKIAS---ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSI 300 + W P + + + ++D+ I+IWNV + + + Q I+W+ I Sbjct: 235 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS----QVCSILWSPHYKELI 290 Query: 301 SANGFIN----FVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 S +GF + GH + +L+ S DG T+ SA A+ + W Sbjct: 291 SGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 347 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 60/292 (20%), Positives = 104/292 (35%), Gaps = 30/292 (10%) Query: 32 KIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQT 91 + N +++ G + + + G Y A G V++WD Q Sbjct: 74 AVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQ 133 Query: 92 THILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNG---NLTGQAR 148 + T S V +SW+S I + G R GH+ D + L+G ++ Sbjct: 134 KRLRNMT--SHSARVGSLSWNS---YILSSGS---RSGHIHHHDVRVAEHHVATLSGHSQ 185 Query: 149 AMNSVDFKPSRPFRIISGSDDNTVAIFEGPP----FKFKSTFGEHTKFVHSVRYNPDGSL 204 + + + P + SG +DN V ++ P + TF +H V +V + P S Sbjct: 186 EVCGLRWAPDGR-HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 244 Query: 205 -FASTG--GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASAS--A 259 A+ G D I ++N G + AHS V + WSP ++ S A Sbjct: 245 VLATGGGTSDRHIRIWNVCSGACLSAVD-------AHS-QVCSILWSPHYKELISGHGFA 296 Query: 260 DKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNP 311 + IW T+ + G L + + S +A+ + Sbjct: 297 QNQLVIWKYPTMAKVAELK-GHTSRVLSLTMSPDGATVASAAADETLRLWRC 347 Score = 105 bits (262), Expect = 6e-23, Method: Composition-based stats. Identities = 46/328 (14%), Positives = 112/328 (34%), Gaps = 57/328 (17%) Query: 290 IIWTKQALVSISANGFINFVNPELGSIDQVRYGHNK--AITALSSSADGKTLFSADAEGH 347 + W+ +++++ + + + G I Q+ I++++ +G L + Sbjct: 65 VDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE 124 Query: 348 INSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVA 407 + WD+ R + + + Sbjct: 125 VQLWDVQQQKRLR-----------------------------------------NMTSHS 143 Query: 408 NKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGG 467 ++ S + + G + + + + H T S + + D + +A GG Sbjct: 144 ARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGG 203 Query: 468 QDSKVHVYKL---SGASVSEVKTIVHPAEITSVAFSNNGAFLVA---TDQSRKVIPYSVA 521 D+ V+V+ G V H + +VA+ + ++A R + ++V Sbjct: 204 NDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC 263 Query: 522 NNFELAHTNSWTFHTAKVACVSWSPDNVRLATG--SLDNSVIVWNMNKPSDHPIIIKGAH 579 + L+ ++ ++V + WSP L +G N +++W P+ + H Sbjct: 264 SGACLSAVDA----HSQVCSILWSPHYKELISGHGFAQNQLVIW--KYPTMAKVAELKGH 317 Query: 580 AMSSVNSVIWLNETTIVSAGQDSNIKFW 607 ++ + + T+ SA D ++ W Sbjct: 318 TSRVLSLTMSPDGATVASAAADETLRLW 345 Score = 99.6 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 44/210 (20%), Positives = 82/210 (39%), Gaps = 16/210 (7%) Query: 411 SSQPLGLAVSADGDIAVAACYKHIAIYSHGK------LTEVPISYNSSCVALSNDKQFVA 464 + L L + G++ A + ++S L S VA + ++A Sbjct: 58 NDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLA 117 Query: 465 VGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNF 524 VG ++V ++ + T H A + S+++ N L + +S + + V Sbjct: 118 VGTSSAEVQLWDVQQQKRLRNMT-SHSARVGSLSW--NSYILSSGSRSGHIHHHDVR--V 172 Query: 525 ELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVW-NMNKPSDHPIIIKGAHAMSS 583 H + + H+ +V + W+PD LA+G DN V VW + + + Sbjct: 173 AEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGA 232 Query: 584 VNSVIWLN--ETTIVSAG--QDSNIKFWNV 609 V +V W + + G D +I+ WNV Sbjct: 233 VKAVAWCPWQSNVLATGGGTSDRHIRIWNV 262 Score = 37.5 bits (85), Expect = 0.018, Method: Composition-based stats. Identities = 9/55 (16%), Positives = 16/55 (29%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDI 109 H+ + SP G AS +R+W + + S + Sbjct: 314 LKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSL 368 >4V8M-A7 nrPDB Length = 318 Score = 180 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 61/353 (17%), Positives = 118/353 (33%), Gaps = 57/353 (16%) Query: 140 NGNLTGQARAMNSVDFK--PSRPFRIISGSDDNTVAIF----EGPPFKFK-----STFGE 188 G LTG + S+ P +++S S D T+ + + + Sbjct: 6 EGQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEG 65 Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 H+ FV V + +G+ S D ++ L+N +G F + H+ V + +S Sbjct: 66 HSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKF-------LGHTKDVLSVAFS 118 Query: 249 PDGTKIASASADKTIKIWNVATLKVEKTIPVG-TRIEDQQLGIIWT--KQALVSISANGF 305 PD +I S D +++WNV + T+ G + + +VS + Sbjct: 119 PDNRQIVSGGRDNALRVWNV-KGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNL 177 Query: 306 INFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDV 365 + + G + GH +T+++ S DG S+D +G WD++ G + Sbjct: 178 VKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAG 237 Query: 366 HATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDI 425 I I + + + +++ + A + Sbjct: 238 A--PINQICFSPNRYWMCAATEKGIRIFDLENKDIIVELAPEH------------QGSKK 283 Query: 426 AVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLS 478 V C +A S D + G D+ + V+ +S Sbjct: 284 IVPECVS---------------------IAWSADGSTLYSGYTDNVIRVWGVS 315 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 58/311 (18%), Positives = 117/311 (37%), Gaps = 23/311 (7%) Query: 14 PRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYY 73 P+T V+ + + + ++ HS + S +G + Sbjct: 22 PQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSDVALSNNGNF 81 Query: 74 CASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFL 133 S ++R+W+ K + V +++ ++++I V GR+ V+ Sbjct: 82 AVSASWDHSLRLWNLQNGQCQYK--FLGHTKDVLSVAFSPDNRQI--VSGGRDNALRVWN 137 Query: 134 FDTGTSNGNLT--GQARAMNSVDFKPS-RPFRIISGSDDNTVAIFEGPPFKFKSTFGEHT 190 G L+ ++ V F PS I+SG DN V +++ + + HT Sbjct: 138 VK-GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHT 196 Query: 191 KFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD 250 +V SV +PDGSL AS+ DG L++ G +L +A + + +SP+ Sbjct: 197 NYVTSVTVSPDGSLCASSDKDGVARLWDLTKGE--------ALSEMAAGAPINQICFSPN 248 Query: 251 GTKIASASADKTIKIWNVATLKVEKTIPVGTR----IEDQQLGIIWT--KQALVSISANG 304 + +A+ I+I+++ + + + I + + I W+ L S + Sbjct: 249 RYWMCAATEKG-IRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDN 307 Query: 305 FINFVNPELGS 315 I + Sbjct: 308 VIRVWGVSENA 318 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 50/295 (16%), Positives = 105/295 (35%), Gaps = 23/295 (7%) Query: 293 TKQALVSISANGFINFVNPE---------LGSIDQVRYGHNKAITALSSSADGKTLFSAD 343 T +VS S + + P G D+ GH+ ++ ++ S +G SA Sbjct: 27 TATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSDVALSNNGNFAVSAS 86 Query: 344 AEGHINSWDISTGISNRVFPDVHATMITGIKTTS-KGDLFTVSWDDHLKVVPAGGSGVDS 402 + + W++ G F H + + + + + D+ L+V G + + Sbjct: 87 WDHSLRLWNLQNGQCQYKFLG-HTKDVLSVAFSPDNRQIVSGGRDNALRVWNVKGECMHT 145 Query: 403 SKAVANKLSSQPLGLAVSADGDIAVAACYKHI---AIYSHGKLTE--VPISYNSSCVALS 457 A+ + + S D + V+ + ++ + G+L + + V +S Sbjct: 146 LSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVS 205 Query: 458 NDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIP 517 D A +D ++ L+ A I + FS N ++ A + + Sbjct: 206 PDGSLCASSDKDGVARLWDLTKGEALSEMAAG--APINQICFSPNRYWMCAATEKG-IRI 262 Query: 518 YSVANNFELAHTN-SWTFHTAKV---ACVSWSPDNVRLATGSLDNSVIVWNMNKP 568 + + N + V ++WS D L +G DN + VW +++ Sbjct: 263 FDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWGVSEN 317 Score = 122 bits (305), Expect = 6e-28, Method: Composition-based stats. Identities = 43/167 (25%), Positives = 71/167 (42%), Gaps = 14/167 (8%) Query: 453 CVALSNDKQFVAVGGQDSKVHVY----KLSGASVSEVKT----IVHPAEITSVAFSNNGA 504 C V +D + + + S H A ++ VA SNNG Sbjct: 21 CPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSDVALSNNGN 80 Query: 505 FLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWN 564 F V+ + +++ N + HT V V++SPDN ++ +G DN++ VWN Sbjct: 81 FAVSASWDHSLRLWNLQNG---QCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWN 137 Query: 565 MNKPSDHPIIIKGAHA--MSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 + H + +GAH +S V L+ IVS G D+ +K W++ Sbjct: 138 VKGECMH-TLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDL 183 Score = 108 bits (269), Expect = 8e-24, Method: Composition-based stats. Identities = 48/217 (22%), Positives = 87/217 (40%), Gaps = 12/217 (5%) Query: 399 GVDSSKAVANKLSSQPLGLAVSADGDIAVAAC--YKHIAIYSHG--KLTEVPISYNSSCV 454 V S + ++ S D + +H + S+G S S V Sbjct: 15 WVTSLACPQTP-ETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSDV 73 Query: 455 ALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRK 514 ALSN+ F D + ++ L + K + H ++ SVAFS + +V+ + Sbjct: 74 ALSNNGNFAVSASWDHSLRLWNLQNGQC-QYKFLGHTKDVLSVAFSPDNRQIVSGGRDNA 132 Query: 515 VIPYSVANNFELAHTNSWTFHTAKVACVSWSP--DNVRLATGSLDNSVIVWNMNKPSDHP 572 + ++V E HT S HT V+CV +SP D + +G DN V VW++ + Sbjct: 133 LRVWNVKG--ECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLA--TGRL 188 Query: 573 IIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 + H + + + + S+ +D + W++ Sbjct: 189 VTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDL 225 Score = 101 bits (252), Expect = 6e-22, Method: Composition-based stats. Identities = 50/307 (16%), Positives = 98/307 (31%), Gaps = 65/307 (21%) Query: 365 VHATMITGI-KTTSKGDLFTVSWDDHLKVVPAGGSGVD---SSKAVANKLSSQPLGLAVS 420 H +T + + V K + + G D S + A Sbjct: 11 GHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFV 70 Query: 421 AD------GDIAVAACYKH-IAIYS--HGKLTEVPISY--NSSCVALSNDKQFVAVGGQD 469 +D G+ AV+A + H + +++ +G+ + + + VA S D + + GG+D Sbjct: 71 SDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSGGRD 130 Query: 470 SKVHVYKLSGASVSEVKTIVHPAEITSVAFSN--NGAFLVATDQSRKVIPYSVANNFELA 527 + + V+ + G + + H ++ V FS + +V+ V + +A Sbjct: 131 NALRVWNVKGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGR--- 187 Query: 528 HTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNK-------------------- 567 HT V V+ SPD A+ D +W++ K Sbjct: 188 LVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSP 247 Query: 568 ------------------PSDHPIIIKGAHA-------MSSVNSVIWLNETTIVSAGQDS 602 + I+ V+ + +T+ S D+ Sbjct: 248 NRYWMCAATEKGIRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDN 307 Query: 603 NIKFWNV 609 I+ W V Sbjct: 308 VIRVWGV 314 >5UZ7-B nrPDB Length = 351 Score = 176 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 56/303 (18%), Positives = 109/303 (35%), Gaps = 18/303 (5%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSE 114 H + S G + IWD+ T + IP+ S V ++ Sbjct: 62 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVH--AIPLRSSWVMTCAYAPS 119 Query: 115 SKRIAAVGEGRERFGHVFLFDTGTSN----GNLTGQARAMNSVDFKPSRPFRIISGSDDN 170 +A G + ++ T N L G ++ F +I++ S D Sbjct: 120 GNYVAC--GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN--QIVTSSGDT 175 Query: 171 TVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFED 230 T A+++ + +TF HT V S+ PD LF S D + L++ +G F Sbjct: 176 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF-- 233 Query: 231 DSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRI-EDQQLG 289 H + + + P+G A+ S D T +++++ + T I + Sbjct: 234 -----TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVS 288 Query: 290 IIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHIN 349 + + L++ + N + V GH+ ++ L + DG + + + + Sbjct: 289 FSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLK 348 Query: 350 SWD 352 W+ Sbjct: 349 IWN 351 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 48/338 (14%), Positives = 101/338 (29%), Gaps = 48/338 (14%) Query: 184 STFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVF 243 T H ++++ + D L S DG +++++ K S V Sbjct: 60 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRS-------SWVM 112 Query: 244 GLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW--TKQALVSIS 301 ++P G +A D I+N+ T + + L +V+ S Sbjct: 113 TCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSS 172 Query: 302 ANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRV 361 + + E G GH + +LS + D + S + WD+ G+ + Sbjct: 173 GDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQT 232 Query: 362 FPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSA 421 F H + I I G+ F D Sbjct: 233 FTG-HESDINAICFFPNGNAFATGSD---------------------------------- 257 Query: 422 DGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGAS 481 D + + ++ + + V+ S + + G D +V+ A Sbjct: 258 DATCRLFDLRADQELMTYSHDNIIC---GITSVSFSKSGRLLLAGYDDFNCNVWDALKAD 314 Query: 482 VSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYS 519 + V H ++ + +++G + + ++ Sbjct: 315 RAGVL-AGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 351 Score = 121 bits (303), Expect = 1e-27, Method: Composition-based stats. Identities = 48/300 (16%), Positives = 96/300 (32%), Gaps = 17/300 (5%) Query: 318 QVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTS 377 + GH I A+ D + L SA +G + WD T P + ++ + Sbjct: 60 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIP-LRSSWVMTCAYAP 118 Query: 378 KGDLFTVS-WDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAA-----CY 431 G+ D+ + + + + L D + V + C Sbjct: 119 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCA 178 Query: 432 KHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHP 491 T + + ++L+ D + G D+ ++ + + T H Sbjct: 179 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFT-GHE 237 Query: 492 AEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVA---CVSWSPDN 548 ++I ++ F NG + + + EL H + VS+S Sbjct: 238 SDINAICFFPNGNAFATGSDDATCRLFDLRADQELMT----YSHDNIICGITSVSFSKSG 293 Query: 549 VRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 L G D + VW+ K ++ + +S + + + + DS +K WN Sbjct: 294 RLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVT--DDGMAVATGSWDSFLKIWN 351 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 46/303 (15%), Positives = 98/303 (32%), Gaps = 23/303 (7%) Query: 275 KTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSA 334 + G + + + LVS S +G + + + + + + + Sbjct: 59 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 118 Query: 335 DGKTLFSADAEGHINSWDISTGISNRVF---PDVHATMITGIKT-------TSKGDLFTV 384 G + + + +++ T N H ++ + TS GD Sbjct: 119 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCA 178 Query: 385 SWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTE 444 WD +G + L ++ + D + + + + Sbjct: 179 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF----- 233 Query: 445 VPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPA---EITSVAFSN 501 + + + + A G D+ ++ L E+ T H ITSV+FS Sbjct: 234 TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQ--ELMTYSHDNIICGITSVSFSK 291 Query: 502 NGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVI 561 +G L+A + + H +V+C+ + D + +ATGS D+ + Sbjct: 292 SGRLLLAGYDDFNCNVWDA---LKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLK 348 Query: 562 VWN 564 +WN Sbjct: 349 IWN 351 Score = 85.7 bits (210), Expect = 5e-17, Method: Composition-based stats. Identities = 33/202 (16%), Positives = 72/202 (35%), Gaps = 16/202 (7%) Query: 412 SQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSK 471 L ++ S DG + + Y + + S+ +C A + +VA GG D+ Sbjct: 77 DSRLLVSASQDGKLIIWDSYTTNKV----HAIPLRSSWVMTC-AYAPSGNYVACGGLDNI 131 Query: 472 VHVYKL---SGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAH 528 +Y L G + H ++ F + +V + + + + Sbjct: 132 CSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-DDNQIVTSSGDTTCALWDIETGQQTTT 190 Query: 529 TNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVI 588 HT V +S +PD +G+ D S +W++ + S +N++ Sbjct: 191 FTG---HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGM---CRQTFTGHESDINAIC 244 Query: 589 -WLNETTIVSAGQDSNIKFWNV 609 + N + D+ + +++ Sbjct: 245 FFPNGNAFATGSDDATCRLFDL 266 Score = 81.1 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 24/176 (13%), Positives = 62/176 (35%), Gaps = 5/176 (2%) Query: 435 AIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEI 494 I + T + D + + QD K+ ++ + + + + Sbjct: 53 RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI-PLRSSWV 111 Query: 495 TSVAFSNNGAFLVATDQSRKVIPYSVANNFELAH-TNSWTFHTAKVACVSWSPDNVRLAT 553 + A++ +G ++ Y++ + HT ++C + D+ ++ T Sbjct: 112 MTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-DDNQIVT 170 Query: 554 GSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 S D + +W++ + H ++ + + VS D++ K W+V Sbjct: 171 SSGDTTCALWDI--ETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 224 >6QDV-o nrPDB Length = 513 Score = 176 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 51/307 (16%), Positives = 113/307 (36%), Gaps = 18/307 (5%) Query: 54 IYTEHSHQTTVAKTSP-SGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWD 112 +++ H+ + + P SG+ S + +++W+ T S V+DI ++ Sbjct: 217 VWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVY-GERRCLRTFIGHSKAVRDICFN 275 Query: 113 SESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPS--RPFRIISGSDDN 170 + + + +R+ ++ +TG T + V F P + ++G D Sbjct: 276 TAGTQFLSAA--YDRYLKLWDTETGQCISRFTN-RKVPYCVKFNPDEDKQNLFVAGMSDK 332 Query: 171 TVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFED 230 + ++ + + H V+++ + + F ST D ++ ++ + Sbjct: 333 KIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAE 392 Query: 231 DSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT--LKVEKTIPVGTRIEDQQL 288 S+ HS +T SP+G +A S D I I+ +K I G + Sbjct: 393 PSM----HSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYAC 446 Query: 289 GIIWTKQALVSISAN--GFINFVNPELGSIDQVRYGHNKAITALSSSA-DGKTLFSADAE 345 + ++ IS + G +N + + + H+K + + + + Sbjct: 447 QVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWD 506 Query: 346 GHINSWD 352 G I WD Sbjct: 507 GLIKLWD 513 Score = 137 bits (344), Expect = 2e-32, Method: Composition-based stats. Identities = 52/300 (17%), Positives = 99/300 (33%), Gaps = 44/300 (14%) Query: 138 TSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP-PFKFKSTFGEHTKFVHSV 196 +G + +++V P ++S S D + ++E + TF H+K V + Sbjct: 213 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDI 272 Query: 197 RYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSL----------------------- 233 +N G+ F S D + L++ G F + + Sbjct: 273 CFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDK 332 Query: 234 --------------KNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPV 279 + H G+V + + + + S S DK++++W K I Sbjct: 333 KIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAE 392 Query: 280 GTRIEDQQLGIIWTKQALVSISANGFINFVNPELG---SIDQVRYGHNKAITA--LSSSA 334 + + + + L S + I + + ++ GH A A + S Sbjct: 393 PSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSP 452 Query: 335 DGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKG-DLFTVSWDDHLKVV 393 D + S D G +N WD T F I + + + T WD +K+ Sbjct: 453 DMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLW 512 Score = 135 bits (340), Expect = 4e-32, Method: Composition-based stats. Identities = 58/357 (16%), Positives = 109/357 (30%), Gaps = 65/357 (18%) Query: 261 KTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPE-LGSIDQV 319 K I +W T+ + L+S S + I + Sbjct: 213 KQIHVW-----------SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRT 261 Query: 320 RYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKG 379 GH+KA+ + + G SA + ++ WD TG F + + +K Sbjct: 262 FIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTN--RKVPYCVKFNPDE 319 Query: 380 D---LFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAI 436 D LF D V SG V +H+ Sbjct: 320 DKQNLFVAGMSDKKIVQWDIRSGE-------------------------IVQEYDRHL-- 352 Query: 437 YSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVY--KLSGASVSEVKTIVHPAEI 494 + + ++ + D + V+ + + +H Sbjct: 353 ------------GAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMP- 399 Query: 495 TSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFH--TAKVACVSWSPDNVRLA 552 +V S NG +L +++ + N F L + H V +SPD + Sbjct: 400 -AVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVI 458 Query: 553 TGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT-IVSAGQDSNIKFWN 608 +G + + +W+ + AH + +V +ET+ +++ G D IK W+ Sbjct: 459 SGDGNGKLNIWDWKTTKLYSR--FKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 513 Score = 86.5 bits (212), Expect = 3e-17, Method: Composition-based stats. Identities = 24/161 (14%), Positives = 61/161 (37%), Gaps = 13/161 (8%) Query: 456 LSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKV 515 + D K+ ++++ G I H + + F+ G ++ R + Sbjct: 231 FPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYL 290 Query: 516 IPYSVANNFELAHTNSWTFHTAKVACVSWSPDN---VRLATGSLDNSVIVWNMNKPSDHP 572 + ++ + CV ++PD G D ++ W++ Sbjct: 291 KLWDTETGQCISRFTN----RKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSG---E 343 Query: 573 IIIKGAHAMSSVNSVIWLNET-TIVSAGQDSNIKF--WNVP 610 I+ + + +VN++++++E VS D +++ W++P Sbjct: 344 IVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIP 384 >5YZG-W nrPDB Length = 579 Score = 175 bits (444), Expect = 4e-44, Method: Composition-based stats. Identities = 51/307 (16%), Positives = 113/307 (36%), Gaps = 18/307 (5%) Query: 54 IYTEHSHQTTVAKTSP-SGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWD 112 +++ H+ + + P SG+ S + +++W+ T S V+DI ++ Sbjct: 283 VWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVY-GERRCLRTFIGHSKAVRDICFN 341 Query: 113 SESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPS--RPFRIISGSDDN 170 + + + +R+ ++ +TG T + V F P + ++G D Sbjct: 342 TAGTQFLSAA--YDRYLKLWDTETGQCISRFTN-RKVPYCVKFNPDEDKQNLFVAGMSDK 398 Query: 171 TVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFED 230 + ++ + + H V+++ + + F ST D ++ ++ + Sbjct: 399 KIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAE 458 Query: 231 DSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT--LKVEKTIPVGTRIEDQQL 288 S+ HS +T SP+G +A S D I I+ +K I G + Sbjct: 459 PSM----HSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYAC 512 Query: 289 GIIWTKQALVSISAN--GFINFVNPELGSIDQVRYGHNKAITALSSSA-DGKTLFSADAE 345 + ++ IS + G +N + + + H+K + + + + Sbjct: 513 QVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWD 572 Query: 346 GHINSWD 352 G I WD Sbjct: 573 GLIKLWD 579 Score = 137 bits (344), Expect = 2e-32, Method: Composition-based stats. Identities = 52/300 (17%), Positives = 99/300 (33%), Gaps = 44/300 (14%) Query: 138 TSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP-PFKFKSTFGEHTKFVHSV 196 +G + +++V P ++S S D + ++E + TF H+K V + Sbjct: 279 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDI 338 Query: 197 RYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSL----------------------- 233 +N G+ F S D + L++ G F + + Sbjct: 339 CFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDK 398 Query: 234 --------------KNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPV 279 + H G+V + + + + S S DK++++W K I Sbjct: 399 KIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAE 458 Query: 280 GTRIEDQQLGIIWTKQALVSISANGFINFVNPELG---SIDQVRYGHNKAITA--LSSSA 334 + + + + L S + I + + ++ GH A A + S Sbjct: 459 PSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSP 518 Query: 335 DGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKG-DLFTVSWDDHLKVV 393 D + S D G +N WD T F I + + + T WD +K+ Sbjct: 519 DMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLW 578 Score = 135 bits (340), Expect = 5e-32, Method: Composition-based stats. Identities = 58/357 (16%), Positives = 109/357 (30%), Gaps = 65/357 (18%) Query: 261 KTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPE-LGSIDQV 319 K I +W T+ + L+S S + I + Sbjct: 279 KQIHVW-----------SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRT 327 Query: 320 RYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKG 379 GH+KA+ + + G SA + ++ WD TG F + + +K Sbjct: 328 FIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTN--RKVPYCVKFNPDE 385 Query: 380 D---LFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAI 436 D LF D V SG V +H+ Sbjct: 386 DKQNLFVAGMSDKKIVQWDIRSGE-------------------------IVQEYDRHL-- 418 Query: 437 YSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVY--KLSGASVSEVKTIVHPAEI 494 + + ++ + D + V+ + + +H Sbjct: 419 ------------GAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMP- 465 Query: 495 TSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFH--TAKVACVSWSPDNVRLA 552 +V S NG +L +++ + N F L + H V +SPD + Sbjct: 466 -AVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVI 524 Query: 553 TGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT-IVSAGQDSNIKFWN 608 +G + + +W+ + AH + +V +ET+ +++ G D IK W+ Sbjct: 525 SGDGNGKLNIWDWKTTKLYSR--FKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579 Score = 86.5 bits (212), Expect = 3e-17, Method: Composition-based stats. Identities = 24/161 (14%), Positives = 61/161 (37%), Gaps = 13/161 (8%) Query: 456 LSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKV 515 + D K+ ++++ G I H + + F+ G ++ R + Sbjct: 297 FPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYL 356 Query: 516 IPYSVANNFELAHTNSWTFHTAKVACVSWSPDN---VRLATGSLDNSVIVWNMNKPSDHP 572 + ++ + CV ++PD G D ++ W++ Sbjct: 357 KLWDTETGQCISRFTN----RKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSG---E 409 Query: 573 IIIKGAHAMSSVNSVIWLNET-TIVSAGQDSNIKF--WNVP 610 I+ + + +VN++++++E VS D +++ W++P Sbjct: 410 IVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIP 450 >5OPT-p nrPDB Length = 318 Score = 175 bits (444), Expect = 4e-44, Method: Composition-based stats. Identities = 54/268 (20%), Positives = 108/268 (40%), Gaps = 23/268 (8%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSE 114 HS + S +G + S ++R+W+ T + + + V +++ + Sbjct: 63 LEGHSAFVSDVALSNNGDFAVSASWDHSLRLWNL--QTGVCQHKFLGHTKDVLSVTFSPD 120 Query: 115 SKRIAAVGEGRERFGHVFLFDTGTSNGNLT--GQARAMNSVDFKPSRPF-RIISGSDDNT 171 +++I V GR+ V+ G L ++ V F PS I+SG DN Sbjct: 121 NRQI--VSGGRDNALRVWNVK-GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNL 177 Query: 172 VAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDD 231 V +++ + + HT ++ SV +PDGSL AS+ DG L++ G Sbjct: 178 VKVWDIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGE-------- 229 Query: 232 SLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTI----PVGTRIEDQQ 287 +L +A + + +SP+ + +A+ I+I+++ V + ++ + Sbjct: 230 ALSEMAAGAPINQICFSPNRYWMCAATEKG-IRIFDLENKDVIVELAPEAQQKSKKTPEC 288 Query: 288 LGIIWT--KQALVSISANGFINFVNPEL 313 + I W+ L S + I + Sbjct: 289 MSIAWSADGNTLYSGYTDNVIRVWSVSE 316 Score = 175 bits (443), Expect = 5e-44, Method: Composition-based stats. Identities = 63/353 (17%), Positives = 118/353 (33%), Gaps = 57/353 (16%) Query: 140 NGNLTGQARAMNSVDFKPSRPFRI--ISGSDDNTVAIF----EGPPFKFK-----STFGE 188 G L G + ++ I +S S DNT+ + + + + Sbjct: 6 EGQLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEG 65 Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 H+ FV V + +G S D ++ L+N G F + H+ V +T+S Sbjct: 66 HSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKF-------LGHTKDVLSVTFS 118 Query: 249 PDGTKIASASADKTIKIWNVATLKVEKTIPVG-TRIEDQQLGIIWT--KQALVSISANGF 305 PD +I S D +++WNV + T+ G + + +VS + Sbjct: 119 PDNRQIVSGGRDNALRVWNV-KGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNL 177 Query: 306 INFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDV 365 + + G + GH IT+++ S DG S+D +G WD++ G + Sbjct: 178 VKVWDIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAG 237 Query: 366 HATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDI 425 I I + + + +++ V A + S+ +S Sbjct: 238 A--PINQICFSPNRYWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKKTPECMS----- 290 Query: 426 AVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLS 478 +A S D + G D+ + V+ +S Sbjct: 291 ----------------------------IAWSADGNTLYSGYTDNVIRVWSVS 315 Score = 166 bits (419), Expect = 3e-41, Method: Composition-based stats. Identities = 58/299 (19%), Positives = 109/299 (36%), Gaps = 32/299 (10%) Query: 74 CASGDVHGNVRIWDTTQTTHILK-------TTIPVFSGPVKDISWDSESKRIAAVGEGRE 126 S + W + + + + S V D++ + AV + Sbjct: 31 AVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALSNNGDF--AVSASWD 88 Query: 127 RFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTF 186 ++ TG G + + SV F P +I+SG DN + ++ + T Sbjct: 89 HSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNR-QIVSGGRDNALRVWNVK-GECLHTL 146 Query: 187 G--EHTKFVHSVRYNPDGS--LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSV 242 G HT +V VR++P L S G D + +++ G + H+ + Sbjct: 147 GRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLK-------GHTNYI 199 Query: 243 FGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISA 302 +T SPDG+ AS+ D ++W++ + + G I Q+ + + + + Sbjct: 200 TSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPI--NQICFSPNRYWMCAATE 257 Query: 303 NGFINFVNPELGSIDQVR-------YGHNKAITALSSSADGKTLFSADAEGHINSWDIS 354 G I + E + +++ SADG TL+S + I W +S Sbjct: 258 KG-IRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGNTLYSGYTDNVIRVWSVS 315 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 58/350 (16%), Positives = 113/350 (32%), Gaps = 63/350 (18%) Query: 237 AHSGSVFGLTWSP-DGTKI--ASASADKTIKIW----NVATLKVEKTIPV----GTRIED 285 H G V L T I S S D T+ W + + + E P G Sbjct: 11 GHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFV 70 Query: 286 QQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAE 345 + + VS S + + N + G GH K + +++ S D + + S + Sbjct: 71 SDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIVSGGRD 130 Query: 346 GHINSWDISTGISNRVF-PDVHATMITGIKTTSKGD---LFTVSWDDHLKVVPAGGSGVD 401 + W++ G H ++ ++ + + + + WD+ +KV Sbjct: 131 NALRVWNVK-GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVW-------- 181 Query: 402 SSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQ 461 DIA + + + V +S D Sbjct: 182 ----------------------DIASGRLLTDLK----------GHTNYITSVTVSPDGS 209 Query: 462 FVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVA 521 A +D ++ L+ A I + FS N ++ A + + + + Sbjct: 210 LCASSDKDGVARLWDLTKGEALSEMAAG--APINQICFSPNRYWMCAATEKG-IRIFDLE 266 Query: 522 NNFELAHT----NSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNK 567 N + + T + ++WS D L +G DN + VW++++ Sbjct: 267 NKDVIVELAPEAQQKSKKTPECMSIAWSADGNTLYSGYTDNVIRVWSVSE 316 Score = 119 bits (297), Expect = 4e-27, Method: Composition-based stats. Identities = 40/156 (25%), Positives = 70/156 (44%), Gaps = 14/156 (8%) Query: 464 AVGGQDSKVHVY----KLSGASV----SEVKTIVHPAEITSVAFSNNGAFLVATDQSRKV 515 +D+ + + + E + H A ++ VA SNNG F V+ + Sbjct: 32 VSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALSNNGDFAVSASWDHSL 91 Query: 516 IPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIII 575 +++ + + HT V V++SPDN ++ +G DN++ VWN+ H + Sbjct: 92 RLWNLQTGV---CQHKFLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNVKGECLH-TLG 147 Query: 576 KGAHA--MSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 +GAH +S V L IVS G D+ +K W++ Sbjct: 148 RGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDI 183 Score = 105 bits (261), Expect = 6e-23, Method: Composition-based stats. Identities = 45/221 (20%), Positives = 84/221 (38%), Gaps = 11/221 (4%) Query: 395 AGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIA----IYSHGKLTEVPISYN 450 G G ++ A + ++ S D + Y + S Sbjct: 10 KGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAF 69 Query: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATD 510 S VALSN+ F D + ++ L + K + H ++ SV FS + +V+ Sbjct: 70 VSDVALSNNGDFAVSASWDHSLRLWNLQTGVC-QHKFLGHTKDVLSVTFSPDNRQIVSGG 128 Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP--DNVRLATGSLDNSVIVWNMNKP 568 + + ++V E HT HT V+CV +SP + + +G DN V VW++ Sbjct: 129 RDNALRVWNVKG--ECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIA-- 184 Query: 569 SDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 S + H + + + + S+ +D + W++ Sbjct: 185 SGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDL 225 Score = 100 bits (248), Expect = 2e-21, Method: Composition-based stats. Identities = 50/307 (16%), Positives = 103/307 (33%), Gaps = 65/307 (21%) Query: 365 VHATMITGIKTTSKGDLF--TVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLG------ 416 H +T + + + VS ++ G + +S+ + L Sbjct: 11 GHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFV 70 Query: 417 --LAVSADGDIAVAACYKH-IAIYS--HGKLTEVPISY--NSSCVALSNDKQFVAVGGQD 469 +A+S +GD AV+A + H + +++ G + + + V S D + + GG+D Sbjct: 71 SDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIVSGGRD 130 Query: 470 SKVHVYKLSGASVSEVKTIVHPAEITSVAFSNN--GAFLVATDQSRKVIPYSVANNFELA 527 + + V+ + G + + H ++ V FS + +V+ V + +A+ L Sbjct: 131 NALRVWNVKGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLL- 189 Query: 528 HTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKP-----------------SD 570 HT + V+ SPD A+ D +W++ K S Sbjct: 190 --TDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSP 247 Query: 571 HPI----------------------------IIKGAHAMSSVNSVIWLNETTIVSAGQDS 602 + K ++ + T+ S D+ Sbjct: 248 NRYWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGNTLYSGYTDN 307 Query: 603 NIKFWNV 609 I+ W+V Sbjct: 308 VIRVWSV 314 Score = 61.8 bits (148), Expect = 9e-10, Method: Composition-based stats. Identities = 26/130 (20%), Positives = 43/130 (33%), Gaps = 8/130 (6%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSE 114 H++ T SP G CAS D G R+WD T+ + + P+ I + Sbjct: 192 LKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAG---APINQICFSPN 248 Query: 115 SKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQAR----AMNSVDFKPSRPFRIISGSDDN 170 + A E R + D Q S+ + + + SG DN Sbjct: 249 RYWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWS-ADGNTLYSGYTDN 307 Query: 171 TVAIFEGPPF 180 + ++ Sbjct: 308 VIRVWSVSEH 317 >6N9G-C nrPDB Length = 353 Score = 175 bits (444), Expect = 4e-44, Method: Composition-based stats. Identities = 56/304 (18%), Positives = 107/304 (35%), Gaps = 17/304 (5%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSE 114 H ++ S G V +WD+ T T+P V ++ Sbjct: 59 LKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPC--TWVMACAYAPS 116 Query: 115 SKRIAAVGEGRERFGHVFLFDTGTS----NGNLTGQARAMNSVDFKPSRPFRIISGSDDN 170 IA G + + FD + ++ +++ F + +I++ S D Sbjct: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSF-TNSDMQILTASGDG 175 Query: 171 TVAIFEGPPFKFKSTFGEHTKFVHSVRYNPD--GSLFASTGGDGTIVLYNGVDGTKTGVF 228 T A+++ + +F H V + P G+ F S G D ++++ G F Sbjct: 176 TCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAF 235 Query: 229 EDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRI-EDQQ 287 E H V + + P G AS S D T +++++ + + I Sbjct: 236 ET-------HESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASS 288 Query: 288 LGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGH 347 + + + L + + IN + GS + +GH ++ L S DG S + Sbjct: 289 VDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHT 348 Query: 348 INSW 351 + W Sbjct: 349 LRVW 352 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 47/305 (15%), Positives = 101/305 (33%), Gaps = 9/305 (2%) Query: 138 TSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVR 197 + L G + +D+ + RI+S S D V +++ + +V + Sbjct: 54 KTRRTLKGHGNKVLCMDWCKDKR-RIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACA 112 Query: 198 YNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASA 257 Y P G A G D +Y H+ + +++ +I +A Sbjct: 113 YAPSGCAIACGGLDNKCSVYPLTFDKNEN-MAAKKKSVAMHTNYLSACSFTNSDMQILTA 171 Query: 258 SADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWT--KQALVSISANGFINFVNPELGS 315 S D T +W+V + ++ ++ G + L + + VS + + G Sbjct: 172 SGDGTCALWDVESGQLLQSF-HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQ 230 Query: 316 IDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMI-TGIK 374 Q H + ++ G S + +D+ ++ + + Sbjct: 231 CVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 290 Query: 375 TTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKH- 433 + G L ++D+ V G S ++ L VS DG + + H Sbjct: 291 FSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVST--LRVSPDGTAFCSGSWDHT 348 Query: 434 IAIYS 438 + +++ Sbjct: 349 LRVWA 353 Score = 128 bits (321), Expect = 7e-30, Method: Composition-based stats. Identities = 49/334 (14%), Positives = 99/334 (29%), Gaps = 49/334 (14%) Query: 237 AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA 296 H V + W D +I S+S D + +W+ T E + + + A Sbjct: 61 GHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMP-CTWVMACAYAPSGCA 119 Query: 297 LVSISANGFINFV------NPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINS 350 + + + N + + + H ++A S + + +A +G Sbjct: 120 IACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCAL 179 Query: 351 WDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKL 410 WD+ +G + F D+ + Sbjct: 180 WDVESGQLLQSFHG------------HGADVLCLDLA---------------------PS 206 Query: 411 SSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDS 470 + ++ D V + + + + V A G D+ Sbjct: 207 ETGNTFVSGGCDKKAMVWDMRSGQCVQAF-----ETHESDVNSVRYYPSGDAFASGSDDA 261 Query: 471 KVHVYKLSGASVSEVKTIVHPAE-ITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHT 529 +Y L + + +SV FS +G L A + + V + Sbjct: 262 TCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKG---SRV 318 Query: 530 NSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVW 563 + H +V+ + SPD +GS D+++ VW Sbjct: 319 SILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 126 bits (316), Expect = 3e-29, Method: Composition-based stats. Identities = 48/308 (15%), Positives = 99/308 (32%), Gaps = 30/308 (9%) Query: 318 QVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTS 377 + GH + + D + + S+ +G + WD T ++ S Sbjct: 57 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 116 Query: 378 KGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKL-------------SSQPLGLAVSADGD 424 + D+ V P ++ A + +S L S DG Sbjct: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 176 Query: 425 IAVAACYKHIAIYSHGKLTEVPISYNSSCVALSND--KQFVAVGGQDSKVHVYKLSGASV 482 A+ + S + C+ L+ GG D K V+ + Sbjct: 177 CALWDVESGQLLQSF-----HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQC 231 Query: 483 SEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKV--- 539 + H +++ SV + +G + Y + + E+ + + + Sbjct: 232 VQAFET-HESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREV----AIYSKESIIFGA 286 Query: 540 ACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAG 599 + V +S L G D ++ VW++ K S I+ + +S++ + + T S Sbjct: 287 SSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLR--VSPDGTAFCSGS 344 Query: 600 QDSNIKFW 607 D ++ W Sbjct: 345 WDHTLRVW 352 Score = 77.2 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 24/160 (15%), Positives = 52/160 (32%), Gaps = 4/160 (2%) Query: 17 ARGTAVVLGNTPAGDK-IQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCA 75 A + L + G+ + + S + + H + PSG A Sbjct: 196 ADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPSGDAFA 255 Query: 76 SGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFD 135 SG R++D + + + + + + A + +V+ Sbjct: 256 SGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFA--GYNDYTINVWDVL 313 Query: 136 TGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF 175 G+ L G ++++ P SGS D+T+ ++ Sbjct: 314 KGSRVSILFGHENRVSTLRVSPDGT-AFCSGSWDHTLRVW 352 Score = 47.2 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 20/90 (22%), Positives = 35/90 (38%), Gaps = 4/90 (4%) Query: 523 NFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWN-MNKPSDHPIIIKGAHAM 581 F + + H KV C+ W D R+ + S D VIVW+ +H + + M Sbjct: 50 QFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVM 109 Query: 582 SSVNSVIWLNETTIVSAGQDSNIKFWNVPF 611 + + + I G D+ + + F Sbjct: 110 ACAYA---PSGCAIACGGLDNKCSVYPLTF 136 >4N14-A nrPDB Length = 314 Score = 174 bits (440), Expect = 1e-43, Method: Composition-based stats. Identities = 58/297 (19%), Positives = 109/297 (36%), Gaps = 22/297 (7%) Query: 65 AKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEG 124 S SG A + +V +W + + + + ++W E +A Sbjct: 27 VDWS-SGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 84 Query: 125 RERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP-PFKFK 183 E ++ N+T + + S+ + + + SGS + + Sbjct: 85 AE--VQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHV 139 Query: 184 STFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVF 243 +T H++ V +R+ PDG AS G D + ++ G V H G+V Sbjct: 140 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV---PLQTFTQHQGAVK 196 Query: 244 GLTWSPDGTKIAS---ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSI 300 + W P + + + ++D+ I+IWNV + + + Q I+W+ I Sbjct: 197 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS----QVCSILWSPHYKELI 252 Query: 301 SANGFIN----FVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 S +GF + GH + +L+ S DG T+ SA A+ + W Sbjct: 253 SGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 309 Score = 141 bits (356), Expect = 7e-34, Method: Composition-based stats. Identities = 60/292 (20%), Positives = 104/292 (35%), Gaps = 30/292 (10%) Query: 32 KIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQT 91 + N +++ G + + + G Y A G V++WD Q Sbjct: 36 AVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQ 95 Query: 92 THILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNG---NLTGQAR 148 + T S V +SW+S I + G R GH+ D + L+G ++ Sbjct: 96 KRLRNMT--SHSARVGSLSWNS---YILSSGS---RSGHIHHHDVRVAEHHVATLSGHSQ 147 Query: 149 AMNSVDFKPSRPFRIISGSDDNTVAIFEGPP----FKFKSTFGEHTKFVHSVRYNPDGSL 204 + + + P + SG +DN V ++ P + TF +H V +V + P S Sbjct: 148 EVCGLRWAPDGR-HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 206 Query: 205 -FASTG--GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASAS--A 259 A+ G D I ++N G + AHS V + WSP ++ S A Sbjct: 207 VLATGGGTSDRHIRIWNVCSGACLSAVD-------AHS-QVCSILWSPHYKELISGHGFA 258 Query: 260 DKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNP 311 + IW T+ + G L + + S +A+ + Sbjct: 259 QNQLVIWKYPTMAKVAELK-GHTSRVLSLTMSPDGATVASAAADETLRLWRC 309 Score = 101 bits (251), Expect = 9e-22, Method: Composition-based stats. Identities = 46/328 (14%), Positives = 112/328 (34%), Gaps = 57/328 (17%) Query: 290 IIWTKQALVSISANGFINFVNPELGSIDQVRYGHNK--AITALSSSADGKTLFSADAEGH 347 + W+ +++++ + + + G I Q+ I++++ +G L + Sbjct: 27 VDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE 86 Query: 348 INSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVA 407 + WD+ R + + + Sbjct: 87 VQLWDVQQQKRLR-----------------------------------------NMTSHS 105 Query: 408 NKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGG 467 ++ S + + G + + + + H T S + + D + +A GG Sbjct: 106 ARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGG 165 Query: 468 QDSKVHVYKL---SGASVSEVKTIVHPAEITSVAFSNNGAFLVA---TDQSRKVIPYSVA 521 D+ V+V+ G V H + +VA+ + ++A R + ++V Sbjct: 166 NDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC 225 Query: 522 NNFELAHTNSWTFHTAKVACVSWSPDNVRLATG--SLDNSVIVWNMNKPSDHPIIIKGAH 579 + L+ ++ ++V + WSP L +G N +++W P+ + H Sbjct: 226 SGACLSAVDA----HSQVCSILWSPHYKELISGHGFAQNQLVIW--KYPTMAKVAELKGH 279 Query: 580 AMSSVNSVIWLNETTIVSAGQDSNIKFW 607 ++ + + T+ SA D ++ W Sbjct: 280 TSRVLSLTMSPDGATVASAAADETLRLW 307 Score = 96.5 bits (238), Expect = 3e-20, Method: Composition-based stats. Identities = 44/210 (20%), Positives = 82/210 (39%), Gaps = 16/210 (7%) Query: 411 SSQPLGLAVSADGDIAVAACYKHIAIYSHGK------LTEVPISYNSSCVALSNDKQFVA 464 + L L + G++ A + ++S L S VA + ++A Sbjct: 20 NDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLA 79 Query: 465 VGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNF 524 VG ++V ++ + T H A + S+++ N L + +S + + V Sbjct: 80 VGTSSAEVQLWDVQQQKRLRNMT-SHSARVGSLSW--NSYILSSGSRSGHIHHHDVR--V 134 Query: 525 ELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVW-NMNKPSDHPIIIKGAHAMSS 583 H + + H+ +V + W+PD LA+G DN V VW + + + Sbjct: 135 AEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGA 194 Query: 584 VNSVIWLN--ETTIVSAG--QDSNIKFWNV 609 V +V W + + G D +I+ WNV Sbjct: 195 VKAVAWCPWQSNVLATGGGTSDRHIRIWNV 224 >6HHQ-h nrPDB Length = 319 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 75/321 (23%), Positives = 121/321 (37%), Gaps = 30/321 (9%) Query: 53 EIYTEHSHQTTVAKTSPSG-YYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGP---VKD 108 H+ T TS S + W T + F G V+D Sbjct: 11 GTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQD 70 Query: 109 ISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSD 168 + ++ + + ++ TG + G + SVD + IISGS Sbjct: 71 CTLTADGAYALSASWDK--TLRLWDVATGETYQRFVGHKSDVMSVDIDK-KASMIISGSR 127 Query: 169 DNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGS------LFASTGGDGTIVLYNGVDG 222 D T+ ++ + +T H +V VR P+ S G D + +N Sbjct: 128 DKTIKVWTIK-GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQF 186 Query: 223 TKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTR 282 F + H+ ++ LT SPDGT IASA D I +WN+A K T+ + Sbjct: 187 QIEADF-------IGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSA--Q 237 Query: 283 IEDQQLGIIWTKQALVSISANGFINF-VNPEL--GSIDQVRYGHNKAI----TALSSSAD 335 E L + L + +A G F ++P+ + G++KA +L+ SAD Sbjct: 238 DEVFSLAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSAD 297 Query: 336 GKTLFSADAEGHINSWDISTG 356 G+TLF+ + I W + T Sbjct: 298 GQTLFAGYTDNVIRVWQVMTA 318 Score = 159 bits (402), Expect = 3e-39, Method: Composition-based stats. Identities = 62/328 (18%), Positives = 116/328 (35%), Gaps = 41/328 (12%) Query: 1 MSEFSQTALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSH 60 ++ + +A P+L +A ++ GD + VPV S + HSH Sbjct: 20 VTSLATSAGQPNLLLSASRDKTLISWKLTGD-------DQKFGVPVRS------FKGHSH 66 Query: 61 QTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAA 120 + G Y S +R+WD + V + D ++ I + Sbjct: 67 IVQDCTLTADGAYALSASWDKTLRLWDVATGETYQR--FVGHKSDVMSVDIDKKASMIIS 124 Query: 121 VGEGRERFGHVFLFDT-GTSNGNLTGQARAMNSVDFKP-----SRPFRIISGSDDNTVAI 174 + + ++ G L G ++ V P IIS +D V Sbjct: 125 GSRDKT----IKVWTIKGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKA 180 Query: 175 FEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLK 234 + F+ ++ F H ++++ +PDG+L AS G DG I+L+N Sbjct: 181 WNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQ--- 237 Query: 235 NVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPV-----GTRIEDQQLG 289 VF L +SP+ +A+A+A IK++++ + + E + Sbjct: 238 -----DEVFSLAFSPNRYWLAAATATG-IKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVS 291 Query: 290 IIWT--KQALVSISANGFINFVNPELGS 315 + W+ Q L + + I + Sbjct: 292 LAWSADGQTLFAGYTDNVIRVWQVMTAN 319 Score = 155 bits (392), Expect = 5e-38, Method: Composition-based stats. Identities = 68/358 (18%), Positives = 122/358 (34%), Gaps = 54/358 (15%) Query: 135 DTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF-----EGPPFKFKSTFGEH 189 + G L G + S+ +P ++S S D T+ + + +F H Sbjct: 5 EVLVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGH 64 Query: 190 TKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP 249 + V DG+ S D T+ L++ G F V H V + Sbjct: 65 SHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRF-------VGHKSDVMSVDIDK 117 Query: 250 DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA------LVSISAN 303 + I S S DKTIK+W + T+ +G Q+ ++ ++A ++S + Sbjct: 118 KASMIISGSRDKTIKVW-TIKGQCLATL-LGHNDWVSQVRVVPNEKADDDSVTIISAGND 175 Query: 304 GFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFP 363 + N I+ GHN I L++S DG + SA +G I W+++ + Sbjct: 176 KMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLS 235 Query: 364 DVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADG 423 + + + + +KV S D Sbjct: 236 AQDE--VFSLAFSPNRYWLAAATATGIKV--------------------------FSLDP 267 Query: 424 DIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGAS 481 V A YS ++ +A S D Q + G D+ + V+++ A+ Sbjct: 268 QYLVDDLRPEFAGYSKA------AEPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTAN 319 Score = 140 bits (353), Expect = 1e-33, Method: Composition-based stats. Identities = 60/339 (17%), Positives = 112/339 (33%), Gaps = 48/339 (14%) Query: 237 AHSGSVFGLTWSPDGT-KIASASADKTIKIWNVATLKVEKTIPV----GTRIEDQQLGII 291 H+G V L S + SAS DKT+ W + + +PV G Q + Sbjct: 15 GHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDCTLT 74 Query: 292 WTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 +S S + + + G Q GH + ++ + S + I W Sbjct: 75 ADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVW 134 Query: 352 DISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLS 411 I G H ++ ++ DD + + G+ D N Sbjct: 135 TIK-GQCLATLLG-HNDWVSQVRVVPNEKA-----DDDSVTIISAGN--DKMVKAWNLNQ 185 Query: 412 SQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSK 471 Q + + N + + S D +A G+D + Sbjct: 186 FQIEADFIGHNS--------------------------NINTLTASPDGTLIASAGKDGE 219 Query: 472 VHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTN- 530 + ++ L+ + T+ E+ S+AFS N +L A + + +S+ + + Sbjct: 220 IMLWNLAAKK--AMYTLSAQDEVFSLAFSPNRYWLAAATATG-IKVFSLDPQYLVDDLRP 276 Query: 531 SWTFHTAKVA----CVSWSPDNVRLATGSLDNSVIVWNM 565 + ++ ++WS D L G DN + VW + Sbjct: 277 EFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQV 315 Score = 101 bits (250), Expect = 1e-21, Method: Composition-based stats. Identities = 49/304 (16%), Positives = 112/304 (36%), Gaps = 61/304 (20%) Query: 319 VRYGHNKAITALSSSA-DGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTS 377 GHN +T+L++SA L SA + + SW Sbjct: 12 TLEGHNGWVTSLATSAGQPNLLLSASRDKTLISW-------------------------- 45 Query: 378 KGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKH---I 434 ++ DD G V S K ++ + ++ADG A++A + + Sbjct: 46 -----KLTGDDQ-----KFGVPVRSFKGHSHIVQD----CTLTADGAYALSASWDKTLRL 91 Query: 435 AIYSHGKLTEVPISYNSSCVALSNDKQ--FVAVGGQDSKVHVYKLSGASVSEVKTIVHPA 492 + G+ + + + S +++ DK+ + G +D + V+ + G ++ + H Sbjct: 92 WDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKGQCLATLL--GHND 149 Query: 493 EITSVAFSNNGAF------LVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP 546 ++ V N +++ + V +++ + H + + ++ SP Sbjct: 150 WVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQ---FQIEADFIGHNSNINTLTASP 206 Query: 547 DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKF 606 D +A+ D +++WN+ + A V S+ + ++A + IK Sbjct: 207 DGTLIASAGKDGEIMLWNLAAKKAMYTLS----AQDEVFSLAFSPNRYWLAAATATGIKV 262 Query: 607 WNVP 610 +++ Sbjct: 263 FSLD 266 >3C9C-A nrPDB Length = 432 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 50/277 (18%), Positives = 105/277 (37%), Gaps = 27/277 (9%) Query: 17 ARGTAVVLGNTPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAKTSPSGY-YC 74 + V+ TP+ D + + P G H + +P+ Y Sbjct: 140 PQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYL 199 Query: 75 ASGDVHGNVRIWDTTQTTHILKTTIP-----VFSGPVKDISWDSESKRI-AAVGEGRERF 128 S + +WD T + + V+D++W + + +V + + Sbjct: 200 LSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQ--- 256 Query: 129 GHVFLFDTGTSN-----GNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKF- 182 + ++DT +N + +N + F P F + +GS D TVA+++ K Sbjct: 257 -KLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK 315 Query: 183 KSTFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV----- 236 +F H + V+++P + ++ AS+G D + +++ + ED Sbjct: 316 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFI 375 Query: 237 --AHSGSVFGLTWSPDGTK-IASASADKTIKIWNVAT 270 H+ + +W+P+ I S S D +++W +A Sbjct: 376 HGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 412 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 51/289 (17%), Positives = 109/289 (37%), Gaps = 44/289 (15%) Query: 102 FSGPVKDISWDSESKRIAAVGEGRERFGHVFLFD----------TGTSNG--NLTGQARA 149 G V + ++ A V + V +FD +G L G + Sbjct: 129 HEGEVNRARYMPQN---ACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKE 185 Query: 150 MNSVDFKPSRPFRIISGSDDNTVAIFEG-------PPFKFKSTFGEHTKFVHSVRYN-PD 201 + + P+ ++S SDD+T+ +++ K+ F HT V V ++ Sbjct: 186 GYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLH 245 Query: 202 GSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGT-KIASASAD 260 SLF S D +++++ + + S AH+ V L+++P +A+ SAD Sbjct: 246 ESLFGSVADDQKLMIWDTRNNNTSK----PSHTVDAHTAEVNCLSFNPYSEFILATGSAD 301 Query: 261 KTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSIS-ANGFINFVNPEL------ 313 KT+ +W++ LK++ + E Q+ + +++ S + ++ + Sbjct: 302 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQS 361 Query: 314 --------GSIDQVRYGHNKAITALSSSADGKT-LFSADAEGHINSWDI 353 + + GH I+ S + + + S + + W + Sbjct: 362 TEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 410 Score = 111 bits (277), Expect = 1e-24, Method: Composition-based stats. Identities = 48/306 (15%), Positives = 94/306 (30%), Gaps = 33/306 (10%) Query: 145 GQARAMNSVDFKPSRPFRIISGSDDNTVAIFEG--------PPFKFKST--FGEHTKFVH 194 +N + P I + + + V +F+ P + + H K + Sbjct: 128 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 187 Query: 195 SVRYNPDGS-LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS-PDGT 252 + +NP+ + S D TI L++ K D H+ V + W + Sbjct: 188 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 247 Query: 253 KIASASADKTIKIWNV---ATLKVEKTIPVGTRIEDQQLGIIWTKQAL-VSISANGFINF 308 S + D+ + IW+ T K T+ T E L + + + SA+ + Sbjct: 248 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHT-AEVNCLSFNPYSEFILATGSADKTVAL 306 Query: 309 VNPELGSI-DQVRYGHNKAITALSSSA-DGKTLFSADAEGHINSWDISTGISNRVFPDV- 365 + + H I + S + L S+ + ++ WD+S + D Sbjct: 307 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAE 366 Query: 366 ------------HATMITGIKTTSKGD-LFTVSWDDHLKVVPAGGSGVDSSKAVANKLSS 412 H I+ + +D++ V V + + S Sbjct: 367 DGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASE 426 Query: 413 QPLGLA 418 A Sbjct: 427 LETNTA 432 Score = 93.0 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 52/274 (18%), Positives = 93/274 (33%), Gaps = 44/274 (16%) Query: 313 LGSIDQVRYGHNKAITALSSSAD-GKTLFSADAEGHINSWDISTGISNRVFPDVHATMIT 371 D GH K LS + + L SA + I WDI+ D + T Sbjct: 172 ECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDA-KNIFT 230 Query: 372 GIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACY 431 G + V+W + + G D + + ++ + + D A Sbjct: 231 GHTAVVED----VAWHLLHESLF-GSVADDQKLMIWDTRNNNTSKPSHTVDAHTA----- 280 Query: 432 KHIAIYSHGKLTEVPISYNSSCVALSNDKQFV-AVGGQDSKVHVYKLSGASVSEVKTIVH 490 +C++ + +F+ A G D V ++ L + H Sbjct: 281 ------------------EVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESH 322 Query: 491 PAEITSVAFSN-NGAFLVATDQSRKVIPYSVANNFELAHTN-----------SWTFHTAK 538 EI V +S N L ++ R++ + ++ E T HTAK Sbjct: 323 KDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAK 382 Query: 539 VACVSWSPDNVR-LATGSLDNSVIVWNMNKPSDH 571 ++ SW+P+ + + S DN + VW M + + Sbjct: 383 ISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYN 416 Score = 85.3 bits (209), Expect = 8e-17, Method: Composition-based stats. Identities = 34/167 (20%), Positives = 73/167 (43%), Gaps = 13/167 (7%) Query: 454 VALSNDKQ-FVAVGGQDSKVHVYKLSG----ASVSEVKTI--VHPAEITSVAFSN-NGAF 505 ++ + + ++ D + ++ ++ V + K I H A + VA+ + + Sbjct: 189 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 248 Query: 506 LVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVWN 564 + +K++ + NN +++ HTA+V C+S++P LATGS D +V +W+ Sbjct: 249 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 308 Query: 565 MNKPSDHPIIIKGAHAMSSVNSVIWLN--ETTIVSAGQDSNIKFWNV 609 + + + V W ET + S+G D + W++ Sbjct: 309 LRNLKLK--LHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 353 Score = 81.1 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 38/319 (11%), Positives = 93/319 (29%), Gaps = 59/319 (18%) Query: 318 QVRYGHNKAITALSSSADGKTLFSADA-EGHINSWDIS--------TGISNRVF-PDVHA 367 +++ H + + + + +D + +G H Sbjct: 124 EIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQ 183 Query: 368 TMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAV 427 G+ + + +S D + + V + + G AV Sbjct: 184 KEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFT--------GHTAV 235 Query: 428 AACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKL--SGASVSEV 485 ++ D K+ ++ + S Sbjct: 236 VEDVAWHLLHE----------------------SLFGSVADDQKLMIWDTRNNNTSKPSH 273 Query: 486 KTIVHPAEITSVAFSNNGAFLVA-TDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSW 544 H AE+ ++F+ F++A + V + + N +S+ H ++ V W Sbjct: 274 TVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK--LKLHSFESHKDEIFQVQW 331 Query: 545 SP-DNVRLATGSLDNSVIVWNMNKPSDH-----------PIIIKGAHAMSSVNSVIWLNE 592 SP + LA+ D + VW+++K + ++ + ++ W Sbjct: 332 SPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPN 391 Query: 593 TTIV--SAGQDSNIKFWNV 609 + S +D+ ++ W + Sbjct: 392 EPWIICSVSEDNIMQVWQM 410 >6EOJ-D nrPDB Length = 470 Score = 171 bits (432), Expect = 1e-42, Method: Composition-based stats. Identities = 53/291 (18%), Positives = 103/291 (35%), Gaps = 17/291 (5%) Query: 24 LGNTPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGN 82 + TP G ++ + +++ S T + H T K S + SGD G Sbjct: 99 IQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGM 158 Query: 83 VRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGN 142 ++IW + ++K + ++D+++ S + + ++ F G Sbjct: 159 IKIWQPNFS--MVKEIDAAHTESIRDMAFSSNDSKFVTCSDD--NILKIWNFSNGKQERV 214 Query: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPD- 201 L+G + S D+ P I S S DN V +++ S+ + V R+ P Sbjct: 215 LSGHHWDVKSCDWHPEMGL-IASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTK 273 Query: 202 GSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP-DGTKIASASAD 260 G+L + D + +++ + L V L W P + + A D Sbjct: 274 GNLLMAISKDKSCRVFDIR-------YSMKELMCVRDETDYMTLEWHPINESMFTLACYD 326 Query: 261 KTIKIWNVATLKVE--KTIPVGTRIEDQQLGIIWTKQALVSISANGFINFV 309 ++K +++ E TIP L + + + I F Sbjct: 327 GSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 144 bits (363), Expect = 1e-34, Method: Composition-based stats. Identities = 51/297 (17%), Positives = 102/297 (34%), Gaps = 18/297 (6%) Query: 60 HQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIA 119 H + +P G G +W+ + T +T + V + + +S + Sbjct: 94 HVIPAIQWTPEGRRLVVATYSGEFSLWNASSFT--FETLMQAHDSAVTTMKYSHDSDWMI 151 Query: 120 AVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPP 179 + + ++ + ++ + F S + ++ SDDN + I+ Sbjct: 152 S--GDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFS-SNDSKFVTCSDDNILKIWNFSN 208 Query: 180 FKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHS 239 K + H V S ++P+ L AS D + L++ G + Sbjct: 209 GKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCIS-------SILKFK 261 Query: 240 GSVFGLTWSPD-GTKIASASADKTIKIWN----VATLKVEKTIPVGTRIEDQQLGIIWTK 294 +V + P G + + S DK+ ++++ + L + +E + Sbjct: 262 HTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFT 321 Query: 295 QALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 A S F N I + Y H+K IT+LS + G +A + I W Sbjct: 322 LACYDGSLKHFDLLQNLNE-PILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 119 bits (299), Expect = 3e-27, Method: Composition-based stats. Identities = 62/344 (18%), Positives = 124/344 (36%), Gaps = 27/344 (7%) Query: 209 GGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNV 268 G D I L F S V H + + W+P+G ++ A+ +WN Sbjct: 73 GRDRVINL--------PSKFTHLSSNKVKHV--IPAIQWTPEGRRLVVATYSGEFSLWNA 122 Query: 269 ATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAIT 328 ++ +T+ + ++S A+G I P + ++ H ++I Sbjct: 123 SSF-TFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIR 181 Query: 329 ALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDD 388 ++ S++ + + + W+ S G RV H + + G + + S D+ Sbjct: 182 DMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDN 241 Query: 389 HLKVV-PAGGSGVDS---SKAVANKLSSQP----LGLAVSADGDIAVAACYKHIAIYSHG 440 +K+ P G+ + S K K QP L +A+S D V YS Sbjct: 242 LVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR-----YSMK 296 Query: 441 KLTEVPISYNSSCVALSN-DKQFVAVGGQDSKVHVYKLSGASVSEVKTI--VHPAEITSV 497 +L V + + ++ + D + + L + TI H ITS+ Sbjct: 297 ELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSL 356 Query: 498 AFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVAC 541 +++ G + R + ++ A + + T++ K+ Sbjct: 357 SYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKING 400 Score = 104 bits (259), Expect = 1e-22, Method: Composition-based stats. Identities = 54/347 (15%), Positives = 112/347 (32%), Gaps = 51/347 (14%) Query: 267 NVATLKVEKTIPVGTRIEDQQLGIIWTKQA--LVSISANGFINFVNPELGSIDQVRYGHN 324 V L + T +++ I WT + LV + +G + N + + + H+ Sbjct: 76 RVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHD 135 Query: 325 KAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTV 384 A+T + S D + S DA+G I W + + H I + +S F Sbjct: 136 SAVTTMKYSHDSDWMISGDADGMIKIWQPN-FSMVKEIDAAHTESIRDMAFSSNDSKFVT 194 Query: 385 SWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTE 444 DD++ + +G K + S Sbjct: 195 CSDDNILKIWNFSNG--------------------------------KQERVLS------ 216 Query: 445 VPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASV-SEVKTIVHPAEITSVAFSNN- 502 ++ + +A +D+ V ++ + S + H + F Sbjct: 217 -GHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHT--VLKTRFQPTK 273 Query: 503 GAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLAT-GSLDNSVI 561 G L+A + + + + + + T + W P N + T D S+ Sbjct: 274 GNLLMAISKDKSCRVFDIR--YSMKELMCVRDETDY-MTLEWHPINESMFTLACYDGSLK 330 Query: 562 VWNMNKPSDHPIIIKGAHAMSSVNSVIWLN-ETTIVSAGQDSNIKFW 607 +++ + + PI+ + S+ + +A +D I+FW Sbjct: 331 HFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 94.6 bits (233), Expect = 1e-19, Method: Composition-based stats. Identities = 33/202 (16%), Positives = 80/202 (39%), Gaps = 9/202 (4%) Query: 414 PLGLAVSADGDIAVAACYKHIAIYSHGKLT--EVPISYNS--SCVALSNDKQFVAVGGQD 469 P + VA ++++ T + +++S + + S+D ++ G D Sbjct: 97 PAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDAD 156 Query: 470 SKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHT 529 + +++ + + V E+ H I +AFS+N + V + ++ +N Sbjct: 157 GMIKIWQPNFSMVKEI-DAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNG---KQE 212 Query: 530 NSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW 589 + H V W P+ +A+ S DN V +W+ + I+K H + Sbjct: 213 RVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQP- 271 Query: 590 LNETTIVSAGQDSNIKFWNVPF 611 +++ +D + + +++ + Sbjct: 272 TKGNLLMAISKDKSCRVFDIRY 293 Score = 40.2 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 15/96 (15%), Positives = 36/96 (37%), Gaps = 5/96 (5%) Query: 516 IPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIII 575 ++ + F +N + + W+P+ RL + +WN + + ++ Sbjct: 76 RVINLPSKFTHLSSNKV---KHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQ 132 Query: 576 KGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNVPF 611 A++++ + ++S D IK W F Sbjct: 133 AHDSAVTTMKY--SHDSDWMISGDADGMIKIWQPNF 166 >5Y1U-A nrPDB Length = 456 Score = 168 bits (425), Expect = 7e-42, Method: Composition-based stats. Identities = 51/288 (17%), Positives = 110/288 (38%), Gaps = 27/288 (9%) Query: 17 ARGTAVVLGNTPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAKTSPS-GYYC 74 + ++ TP+ D + + P G H + +P+ + Sbjct: 165 PQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHL 224 Query: 75 ASGDVHGNVRIWDTTQTTHILKTTIP-----VFSGPVKDISWDSESKRI-AAVGEGRERF 128 S + +WD + K + V+D+SW + + +V + + Sbjct: 225 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQ--- 281 Query: 129 GHVFLFDTGTSN-----GNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKF- 182 + ++DT ++N ++ +N + F P F + +GS D TVA+++ K Sbjct: 282 -KLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK 340 Query: 183 KSTFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV----- 236 +F H + V+++P + ++ AS+G D + +++ + ED Sbjct: 341 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFI 400 Query: 237 --AHSGSVFGLTWSPDGTK-IASASADKTIKIWNVATLKVEKTIPVGT 281 H+ + +W+P+ I S S D +++W +A P G+ Sbjct: 401 HGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGS 448 Score = 129 bits (325), Expect = 3e-30, Method: Composition-based stats. Identities = 54/289 (18%), Positives = 110/289 (38%), Gaps = 44/289 (15%) Query: 102 FSGPVKDISWDSESKRIAAVGEGRERFGHVFLFD----------TGTSNG--NLTGQARA 149 G V + ++ I A + V +FD +G N L G + Sbjct: 154 HEGEVNRARYMPQNPCIIAT---KTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKE 210 Query: 150 MNSVDFKPSRPFRIISGSDDNTVAIFE-------GPPFKFKSTFGEHTKFVHSVRYNP-D 201 + + P+ ++S SDD+T+ +++ G K+ F HT V V ++ Sbjct: 211 GYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH 270 Query: 202 GSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGT-KIASASAD 260 SLF S D +++++ + S AH+ V L+++P +A+ SAD Sbjct: 271 ESLFGSVADDQKLMIWDTRSNNTSK----PSHSVDAHTAEVNCLSFNPYSEFILATGSAD 326 Query: 261 KTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSIS-ANGFINFVNPEL------ 313 KT+ +W++ LK++ + E Q+ + +++ S + +N + Sbjct: 327 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQS 386 Query: 314 --------GSIDQVRYGHNKAITALSSSADGKT-LFSADAEGHINSWDI 353 + + GH I+ S + + + S + + W + Sbjct: 387 PEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 435 Score = 91.9 bits (226), Expect = 7e-19, Method: Composition-based stats. Identities = 56/328 (17%), Positives = 107/328 (32%), Gaps = 55/328 (16%) Query: 270 TLKVEKTIPVGTRIEDQQLGIIWTKQALVSI---SANGFINFVNPE--------LGSIDQ 318 + K+E I + E + + +++ S++ + + D Sbjct: 143 SGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDL 202 Query: 319 VRYGHNKAITALSSSAD-GKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTS 377 GH K LS + + L SA + I WDIS Sbjct: 203 RLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDIS-------------------AVPK 243 Query: 378 KGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIY 437 +G + D D S + ++ L +V+ D + + + Sbjct: 244 EGKVV----DAKTIFTGHTAVVEDVSWHLLHES----LFGSVADDQKLMIWDTRSNNTSK 295 Query: 438 SHGKLTEVPISYNSSCVALSNDKQFV-AVGGQDSKVHVYKLSGASVSEVKTIVHPAEITS 496 + N C++ + +F+ A G D V ++ L + H EI Sbjct: 296 PSHSVDAHTAEVN--CLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQ 353 Query: 497 VAFSN-NGAFLVATDQSRKVIPYSVANNFELAHTN-----------SWTFHTAKVACVSW 544 V +S N L ++ R++ + ++ E HTAK++ SW Sbjct: 354 VQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSW 413 Query: 545 SPDNVR-LATGSLDNSVIVWNMNKPSDH 571 +P+ + + S DN + VW M + + Sbjct: 414 NPNEPWVICSVSEDNIMQVWQMAENIYN 441 Score = 83.4 bits (204), Expect = 3e-16, Method: Composition-based stats. Identities = 35/157 (22%), Positives = 69/157 (43%), Gaps = 12/157 (7%) Query: 463 VAVGGQDSKVHVYKLSG----ASVSEVKTI--VHPAEITSVAFSN-NGAFLVATDQSRKV 515 + D + ++ +S V + KTI H A + V++ + + + +K+ Sbjct: 224 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 283 Query: 516 IPYSVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVWNMNKPSDHPII 574 + + +N ++S HTA+V C+S++P LATGS D +V +W++ + Sbjct: 284 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK--L 341 Query: 575 IKGAHAMSSVNSVIWLN--ETTIVSAGQDSNIKFWNV 609 + V W ET + S+G D + W++ Sbjct: 342 HSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 378 Score = 82.2 bits (201), Expect = 6e-16, Method: Composition-based stats. Identities = 46/321 (14%), Positives = 96/321 (29%), Gaps = 63/321 (19%) Query: 318 QVRYGHNKAITALSSSADGKTLFSADA-EGHINSWDIS--------TGISNRVF-PDVHA 367 +++ H + + + + +D + +G N H Sbjct: 149 EIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQ 208 Query: 368 TMITGIKTTSK--GDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDI 425 G+ G L + S DDH + + K V K G Sbjct: 209 KEGYGLSWNPNLSGHLLSAS-DDHTICLWDISAVPKEGKVVDAKTIFT---------GHT 258 Query: 426 AVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKL--SGASVS 483 AV ++ D K+ ++ + S Sbjct: 259 AVVEDVSWHLLHE----------------------SLFGSVADDQKLMIWDTRSNNTSKP 296 Query: 484 EVKTIVHPAEITSVAFSNNGAFLVA-TDQSRKVIPYSVANNFELAHTNSWTFHTAKVACV 542 H AE+ ++F+ F++A + V + + N +S+ H ++ V Sbjct: 297 SHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK--LKLHSFESHKDEIFQV 354 Query: 543 SWSP-DNVRLATGSLDNSVIVWNMNKPSDH-----------PIIIKGAHAMSSVNSVIWL 590 WSP + LA+ D + VW+++K + ++ + ++ W Sbjct: 355 QWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWN 414 Query: 591 NETTIV--SAGQDSNIKFWNV 609 V S +D+ ++ W + Sbjct: 415 PNEPWVICSVSEDNIMQVWQM 435 >5Y88-O nrPDB Length = 451 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 59/366 (16%), Positives = 119/366 (32%), Gaps = 49/366 (13%) Query: 137 GTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSV 196 + + G + V P I+GS+D T+ +++ K K+T H V V Sbjct: 129 WKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDV 188 Query: 197 RYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIAS 256 + S D T+ ++ + H V ++ P IA+ Sbjct: 189 AVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYY-------GHLSGVRTVSIHPTLDLIAT 241 Query: 257 ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSI 316 A D IK+W++ T T+ VG + Q+ +VS S + + + G Sbjct: 242 AGRDSVIKLWDMRTRIPVITL-VGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKT 300 Query: 317 DQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTT 376 +V H +++ A + ++ SA + I SW ++ G F +I + Sbjct: 301 MKVLTHHKRSVRATALHPKEFSVASACTDD-IRSWGLAEGSLLTNFESEKTGIINTLSIN 359 Query: 377 SKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAI 436 D+ D+ + SG +K+ ++ Sbjct: 360 QD-DVLFAGGDNGVLSFYDYKSG-------------------------------HKYQSL 387 Query: 437 YSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITS 496 + + + + C + G D + ++K + E + Sbjct: 388 ATREMVGSLEGERSVLCSTFDKTGLRLITGEADKSIKIWKQDETATKESEP--------G 439 Query: 497 VAFSNN 502 +A++ N Sbjct: 440 LAWNPN 445 Score = 158 bits (398), Expect = 9e-39, Method: Composition-based stats. Identities = 52/271 (19%), Positives = 98/271 (36%), Gaps = 15/271 (5%) Query: 95 LKTTIPVFSGPVKDISWDS-ESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSV 153 L I G V+ ++ D +++ V+ TG L G + V Sbjct: 131 LSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTM--KVWDLATGKLKTTLAGHVMTVRDV 188 Query: 154 DFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGT 213 P+ + S S+D TV ++ + + H V +V +P L A+ G D Sbjct: 189 AVSDRHPY-LFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSV 247 Query: 214 IVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKV 273 I L++ V H G + + +P ++ S+S D T+++W+V K Sbjct: 248 IKLWDMRTRIPVITL-------VGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKT 300 Query: 274 EKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYG-HNKAITALSS 332 K + + + + + ++ S + I GS+ I LS Sbjct: 301 MKVL-THHKRSVRATALHPKEFSVASACTDD-IRSWGLAEGSLLTNFESEKTGIINTLSI 358 Query: 333 SADGKTLFSADAEGHINSWDISTGISNRVFP 363 + D LF+ G ++ +D +G + Sbjct: 359 NQDD-VLFAGGDNGVLSFYDYKSGHKYQSLA 388 Score = 155 bits (390), Expect = 6e-38, Method: Composition-based stats. Identities = 55/330 (16%), Positives = 106/330 (32%), Gaps = 23/330 (6%) Query: 49 LTDTEIYTEHSHQTTVAKTSP-SGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVK 107 + + H P + +G +++WD T LKTT+ V+ Sbjct: 129 WKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLA--TGKLKTTLAGHVMTVR 186 Query: 108 DISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGS 167 D++ + +V E + + + + G + +V P+ I + Sbjct: 187 DVAVSDRHPYLFSVSEDK--TVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDL-IATAG 243 Query: 168 DDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGV 227 D+ + +++ T H ++ V+ P S+ D T+ L++ V G V Sbjct: 244 RDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKV 303 Query: 228 FEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQ 287 H SV P +ASA D I+ W +A + Sbjct: 304 LTH-------HKRSVRATALHPKEFSVASACTDD-IRSWGLAEGSLLTNFESEKTGIINT 355 Query: 288 LGIIWTKQALVSISANGFINFVNPELGSIDQVRYGH--------NKAITALSSSADGKTL 339 L I L + NG ++F + + G Q +++ + G L Sbjct: 356 LSINQD-DVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKTGLRL 414 Query: 340 FSADAEGHINSWDISTGISNRVFPDVHATM 369 + +A+ I W + P + Sbjct: 415 ITGEADKSIKIWKQDETATKESEPGLAWNP 444 Score = 119 bits (297), Expect = 5e-27, Method: Composition-based stats. Identities = 50/307 (16%), Positives = 97/307 (31%), Gaps = 29/307 (9%) Query: 36 CNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHIL 95 V+ + G L T H S Y S V+ WD + I Sbjct: 161 DTTMKVWDLATGKLKTT--LAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIR 218 Query: 96 KTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDF 155 V+ +S IA G R+ ++ T L G +N V Sbjct: 219 D--YYGHLSGVRTVSIHPTLDLIATAG--RDSVIKLWDMRTRIPVITLVGHKGPINQVQC 274 Query: 156 KPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIV 215 P P +++S S D TV +++ K H + V + +P AS D I Sbjct: 275 TPVDP-QVVSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVASACTDD-IR 332 Query: 216 LYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEK 275 + +G+ FE + +G + L+ + D + + + + ++ + + Sbjct: 333 SWGLAEGSLLTNFESEK------TGIINTLSINQDD-VLFAGGDNGVLSFYDYKSGHKYQ 385 Query: 276 TI-------PVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAIT 328 ++ + T L++ A+ I + + + G Sbjct: 386 SLATREMVGSLEGERSVLCSTFDKTGLRLITGEADKSIKIWKQDETATKESEPG------ 439 Query: 329 ALSSSAD 335 L+ + + Sbjct: 440 -LAWNPN 445 Score = 117 bits (292), Expect = 2e-26, Method: Composition-based stats. Identities = 59/339 (17%), Positives = 115/339 (33%), Gaps = 53/339 (15%) Query: 237 AHSGSVFGLTWSP-DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQ 295 H G V + P D + S D T+K+W++AT K++ T+ G + + + + Sbjct: 137 GHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTL-AGHVMTVRDVAVSDRHP 195 Query: 296 ALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIST 355 L S+S + + + E I + YGH + +S + +A + I WD+ T Sbjct: 196 YLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRT 255 Query: 356 GISNRVFPDVHATMITGI-KTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQP 414 I H I + T + + S D +++ Sbjct: 256 RIPVITLVG-HKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAG---------------- 298 Query: 415 LGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHV 474 K + + +H K + AL + VA D + Sbjct: 299 -----------------KTMKVLTHHKRS-------VRATALHPKEFSVASACTD-DIRS 333 Query: 475 YKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHT----- 529 + L+ S+ I +++ + + L A + + Y + + Sbjct: 334 WGLAEGSLLTNFESEKTGIINTLSINQD-DVLFAGGDNGVLSFYDYKSGHKYQSLATREM 392 Query: 530 -NSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNK 567 S + V C ++ +RL TG D S+ +W ++ Sbjct: 393 VGSLEGERS-VLCSTFDKTGLRLITGEADKSIKIWKQDE 430 Score = 103 bits (255), Expect = 3e-22, Method: Composition-based stats. Identities = 34/178 (19%), Positives = 71/178 (39%), Gaps = 8/178 (4%) Query: 433 HIAIYSHGKLTEVPISYNSSCVALSN-DKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHP 491 A + ++ + + CVA+ D ++ G D+ + V+ L+ + H Sbjct: 125 WHAPWKLSRVINGHLGW-VRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTL-AGHV 182 Query: 492 AEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRL 551 + VA S+ +L + + + V + + N + H + V VS P + Sbjct: 183 MTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKN---QIIRDYYGHLSGVRTVSIHPTLDLI 239 Query: 552 ATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 AT D+ + +W+M + P+I H + +VS+ D+ ++ W+V Sbjct: 240 ATAGRDSVIKLWDMR--TRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDV 295 Score = 92.2 bits (227), Expect = 5e-19, Method: Composition-based stats. Identities = 39/307 (12%), Positives = 92/307 (29%), Gaps = 18/307 (5%) Query: 315 SIDQVRYGHNKAITALSSSA-DGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGI 373 + +V GH + ++ D + + + + WD++TG + H + + Sbjct: 130 KLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGK-LKTTLAGHVMTVRDV 188 Query: 374 KTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKH 433 + + +D + + + + + D IA A Sbjct: 189 AVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDL-IATAGRDSV 247 Query: 434 IAIYSHGKLTEV----PISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV 489 I ++ V + V + V D+ V ++ + +V T Sbjct: 248 IKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTH- 306 Query: 490 HPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNV 549 H + + A + + + + +A L TN + T + +S + D Sbjct: 307 HKRSVRATALHPKEFSVASACTD-DIRSWGLAEGSLL--TNFESEKTGIINTLSINQD-D 362 Query: 550 RLATGSLDNSVIVWNMNKPSDHPIIIKGA------HAMSSVNSVIWLNETTIVSAGQDSN 603 L G + + ++ + + S + S +++ D + Sbjct: 363 VLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKTGLRLITGEADKS 422 Query: 604 IKFWNVP 610 IK W Sbjct: 423 IKIWKQD 429 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 26/216 (12%), Positives = 72/216 (33%), Gaps = 27/216 (12%) Query: 414 PLGLAVSADGDIAVAACY-----KHIAIYSHGKLTEVPISYNSSC--------------- 453 P L+ +G + C + + T + + ++ Sbjct: 128 PWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRD 187 Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSR 513 VA+S+ ++ +D V + L + H + + +V+ + + Sbjct: 188 VAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDY-YGHLSGVRTVSIHPTLDLIATAGRDS 246 Query: 514 KVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPI 573 + + + + + H + V +P + ++ + S D +V +W++ + Sbjct: 247 VIKLWDMRTRIPVI---TLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKV 303 Query: 574 IIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 + H SV + + V++ +I+ W + Sbjct: 304 LT---HHKRSVRATALHPKEFSVASACTDDIRSWGL 336 >5Z56-q nrPDB Length = 504 Score = 164 bits (415), Expect = 9e-41, Method: Composition-based stats. Identities = 46/261 (17%), Positives = 99/261 (37%), Gaps = 15/261 (5%) Query: 150 MNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTG 209 + ++D PS +I++G D V +F+ + +T HTK V SV ++P L S Sbjct: 224 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSAS 283 Query: 210 GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVA 269 D TI +++ + + V AH +V GL+ G + S+S D + W + Sbjct: 284 PDATIRIWSVPNASCVQVVR-------AHESAVTGLSLHATGDYLLSSSDD---QYWAFS 333 Query: 270 TLKVEKTIPVGTRIED----QQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNK 325 ++ + + T + + + I + + + GH+ Sbjct: 334 DIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSG 393 Query: 326 AITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTV- 384 IT+++ S +G L +A + + WD+ + + + + + G + Sbjct: 394 PITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALG 453 Query: 385 SWDDHLKVVPAGGSGVDSSKA 405 D + + + ++ Sbjct: 454 GTDVQIYICKQWTEILHFTEH 474 Score = 145 bits (365), Expect = 6e-35, Method: Composition-based stats. Identities = 38/266 (14%), Positives = 82/266 (30%), Gaps = 16/266 (6%) Query: 47 GSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPV 106 S H+ + T PS S +RIW + V Sbjct: 252 SSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPN--ASCVQVVRAHESAV 309 Query: 107 KDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQAR--AMNSVDFKPSRPFRII 164 +S + + + + + + TG +T + ++ F P Sbjct: 310 TGLSLHATGDYLLSSSDDQ--YWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPD-GLIFG 366 Query: 165 SGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTK 224 +G+ D+ + I++ + F H+ + S+ ++ +G A+ D ++ L++ Sbjct: 367 TGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKN 426 Query: 225 TGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIE 284 + D+ + V L + GT +A D I I E Sbjct: 427 FKTLQLDN------NFEVKSLIFDQSGTYLALGGTDVQIYI---CKQWTEILHFTEHSGL 477 Query: 285 DQQLGIIWTKQALVSISANGFINFVN 310 + + + S + + F + Sbjct: 478 TTGVAFGHHAKFIASTGMDRSLKFYS 503 Score = 137 bits (345), Expect = 1e-32, Method: Composition-based stats. Identities = 51/312 (16%), Positives = 106/312 (33%), Gaps = 60/312 (19%) Query: 90 QTTHILKTTIPVFSGPV-KDISWD---SESKRIAAVGEGRERFGHVFLFDTGTSNGNLTG 145 + + + + S + ++ D S++ +I G + VF + L G Sbjct: 205 SKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVV--VFDKSSEQILATLKG 262 Query: 146 QARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFV------------ 193 + + SV F PS+ + S S D T+ I+ P H V Sbjct: 263 HTKKVTSVVFHPSQDL-VFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYL 321 Query: 194 --------------------------------HSVRYNPDGSLFASTGGDGTIVLYNGVD 221 +++PDG +F + D I +++ + Sbjct: 322 LSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKE 381 Query: 222 GTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGT 281 T F HSG + + +S +G +A+A+ D ++K+W++ LK KT+ + Sbjct: 382 RTNVANFP-------GHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDN 434 Query: 282 RIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFS 341 E + L + L + + + + H+ T ++ K + S Sbjct: 435 NFEVKSLIFDQSGTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIAS 492 Query: 342 ADAEGHINSWDI 353 + + + + Sbjct: 493 TGMDRSLKFYSL 504 Score = 124 bits (312), Expect = 7e-29, Method: Composition-based stats. Identities = 50/278 (17%), Positives = 99/278 (35%), Gaps = 11/278 (3%) Query: 293 TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 +++ A+ + + I GH K +T++ +FSA + I W Sbjct: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292 Query: 353 ISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSS 412 + +V H + +TG+ + GD S DD +G +K Sbjct: 293 VPNASCVQVVR-AHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351 Query: 413 QPLGLAVSADGDI-AVAACYKHIAIYSHGKLTEV----PISYNSSCVALSNDKQFVAVGG 467 DG I I I+ + T V S + +A S + ++A Sbjct: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA 411 Query: 468 QDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELA 527 DS V ++ L + + + E+ S+ F +G +L ++ E+ Sbjct: 412 DDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYI--CKQWTEIL 469 Query: 528 HTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM 565 H +T H+ V++ +A+ +D S+ +++ Sbjct: 470 H---FTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504 Score = 93.4 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 26/159 (16%), Positives = 67/159 (42%), Gaps = 4/159 (2%) Query: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATD 510 + V + V D+ + ++ + AS +V H + +T ++ G +L+++ Sbjct: 267 VTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQV-VRAHESAVTGLSLHATGDYLLSSS 325 Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 + + L T + + C + PD + TG++D+ + +W++ + ++ Sbjct: 326 DDQYWAFSDIQTGRVLTKVTDETSGCS-LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN 384 Query: 571 HPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 + H+ + N + +A DS++K W++ Sbjct: 385 --VANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDL 421 Score = 86.5 bits (212), Expect = 4e-17, Method: Composition-based stats. Identities = 43/290 (14%), Positives = 93/290 (32%), Gaps = 53/290 (18%) Query: 325 KAITALSSSA-DGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDL-F 382 I AL D + + A+ ++ +D S+ H +T + DL F Sbjct: 222 PGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKG-HTKKVTSVVFHPSQDLVF 280 Query: 383 TVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKL 442 + S D +++ + A+C + + Sbjct: 281 SASPDATIRIW------------------------------SVPNASCVQVVR------- 303 Query: 443 TEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPA-EITSVAFSN 501 + ++L ++ D + V T +T F Sbjct: 304 ---AHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP 360 Query: 502 NGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVI 561 +G ++ + + +A ++ H+ + +++S + LAT + D+SV Sbjct: 361 DGLIFGTGTMDSQIKIWDLKERTNVA---NFPGHSGPITSIAFSENGYYLATAADDSSVK 417 Query: 562 VWNMNKPSDHPIIIKGAHAMSSVNSVIWL-NETTIVSAGQDSNI---KFW 607 +W++ K + + + V S+I+ + T + G D I K W Sbjct: 418 LWDLRKLKNFKTLQLDNNFE--VKSLIFDQSGTYLALGGTDVQIYICKQW 465 Score = 64.5 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 23/123 (18%), Positives = 44/123 (35%), Gaps = 6/123 (4%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSE 114 + HS T S +GYY A+ +V++WD + + + + VK + +D Sbjct: 388 FPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLD-NNFEVKSLIFDQS 446 Query: 115 SKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAI 174 +A G +++ T + T + V F I S D ++ Sbjct: 447 GTYLALGGTD----VQIYICKQWTEILHFTEHSGLTTGVAFG-HHAKFIASTGMDRSLKF 501 Query: 175 FEG 177 + Sbjct: 502 YSL 504 Score = 50.3 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 18/73 (24%), Positives = 35/73 (47%), Gaps = 3/73 (4%) Query: 539 VACVSWSP-DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVS 597 + + P D ++ TG D +V+V++ K S+ + H + V ++ + S Sbjct: 224 ILALDLCPSDTNKILTGGADKNVVVFD--KSSEQILATLKGHTKKVTSVVFHPSQDLVFS 281 Query: 598 AGQDSNIKFWNVP 610 A D+ I+ W+VP Sbjct: 282 ASPDATIRIWSVP 294 >5WLC-LU nrPDB Length = 489 Score = 163 bits (413), Expect = 2e-40, Method: Composition-based stats. Identities = 70/325 (21%), Positives = 122/325 (37%), Gaps = 41/325 (12%) Query: 316 IDQVRYGHNKAITALSSSADG-KTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIK 374 + Q+ YGH + A++ + L + A+G I W++ST F H ++TG+ Sbjct: 59 VGQLGYGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFK-AHYGLVTGLC 117 Query: 375 TTSKG----------DLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQ---PLGLAVSA 421 T F +S D K V VD + + GL + Sbjct: 118 VTQPRFHDKKPDLKSQNFMLSCSDD-KTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTF 176 Query: 422 DGDIAVAACYKH------------IAIYSHGKLTEVP-ISYNSSCVAL----SNDKQFVA 464 DG+ A H I ++ +L V +S+ + + N+ +A Sbjct: 177 DGESAFQGIDSHRENSTFATGGAKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILA 236 Query: 465 VGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAF-LVATDQSRKVIPYSVANN 523 G D+ + +Y L S ++ IV ++ ++ AF V ++ Y + N Sbjct: 237 STGSDNSIVLYDLRTNSPTQ--KIVQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNL 294 Query: 524 FELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSS 583 N + H + V V +SP + TGS D S+ ++ N H I M Sbjct: 295 SR--SLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTN--HGHSREIYHTKRMQH 350 Query: 584 VNSVIW-LNETTIVSAGQDSNIKFW 607 V V + ++ I+S D N++ W Sbjct: 351 VFQVKYSMDSKYIISGSDDGNVRLW 375 Score = 104 bits (260), Expect = 1e-22, Method: Composition-based stats. Identities = 48/322 (14%), Positives = 104/322 (32%), Gaps = 40/322 (12%) Query: 16 TARGTAVVLGNTPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAKTS------ 68 G + N + +K+ + V + + + + H T + Sbjct: 66 HRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFHD 125 Query: 69 -----PSGYYCASGDVHGNVRIW---------------DTTQTTHILKTTIPVFSGPVKD 108 S + S V++W D+ L T S Sbjct: 126 KKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQGI 185 Query: 109 ISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSD 168 S E+ A G H++ + +L+ A + S+ F + + S Sbjct: 186 DS-HRENSTFATGGA----KIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGS 240 Query: 169 DNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSL-FASTGGDGTIVLYNGVDGTKTGV 227 DN++ +++ + T +++ +NP + F + D Y+ + +++ Sbjct: 241 DNSIVLYDLRTNSPTQKIVQ-TMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLN 299 Query: 228 FEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQ 287 D H +V + +SP G +I + S DK+I+I+ + Q Sbjct: 300 VFKD------HVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQHVFQ 353 Query: 288 LGIIWTKQALVSISANGFINFV 309 + + ++S S +G + Sbjct: 354 VKYSMDSKYIISGSDDGNVRLW 375 Score = 103 bits (255), Expect = 3e-22, Method: Composition-based stats. Identities = 50/371 (13%), Positives = 106/371 (28%), Gaps = 62/371 (16%) Query: 145 GQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSV-----RYN 199 G + ++ ++ +GS D + + + +F H V + R++ Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFH 124 Query: 200 ---PD---GSLFASTGGDGTIVLYNGV---------DGTKTGVFEDDSLKNVAHSGSVFG 244 PD + S D T+ L++ + E+ ++ + G Sbjct: 125 DKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQG 184 Query: 245 LTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANG 304 + + + A+ A I +W+V LK + G L S ++ Sbjct: 185 IDSHRENSTFATGGAK--IHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDN 242 Query: 305 FINFVNPELGSIDQVRYGHNKAITALSSSADGKT-LFSADAEGHINSWDISTGISNRVFP 363 I + S Q A+ + +A+ + + +D+ + Sbjct: 243 SIVLYDLRTNSPTQKIV-QTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVF 301 Query: 364 DVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADG 423 H + + + + GD D + G Sbjct: 302 KDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSRE-------------------- 341 Query: 424 DIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVS 483 IY ++ V V S D +++ G D V +++ S Sbjct: 342 ------------IYHTKRMQHVFQ------VKYSMDSKYIISGSDDGNVRLWRSKAWERS 383 Query: 484 EVKTIVHPAEI 494 VKT ++ Sbjct: 384 NVKTTREKNKL 394 Score = 99.6 bits (246), Expect = 4e-21, Method: Composition-based stats. Identities = 45/346 (13%), Positives = 103/346 (29%), Gaps = 45/346 (13%) Query: 101 VFSGPVKDIS--WDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSV----- 153 V I+ + S +K +G ++ + T + + + Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKY---WNMSTREEFVSFKAHYGLVTGLCVTQP 121 Query: 154 DFKPSRPFR-----IISGSDDNTVAIFEGPPFK-----------------FKSTFGEHTK 191 F +P ++S SDD TV ++ TF Sbjct: 122 RFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDG-ES 180 Query: 192 FVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG 251 + + + S FA+ G I L++ + ++ L ++ + Sbjct: 181 AFQGIDSHRENSTFATGGA--KIHLWDVNRLKPVSDLSWGA-------DNITSLKFNQNE 231 Query: 252 T-KIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVN 310 T +AS +D +I ++++ T + I V T + V+ + + + + Sbjct: 232 TDILASTGSDNSIVLYDLRTNSPTQKI-VQTMRTNAICWNPMEAFNFVTANEDHNAYYYD 290 Query: 311 PEL-GSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATM 369 V H A+ + S G + + + I + + G S ++ Sbjct: 291 MRNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQH 350 Query: 370 ITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPL 415 + +K + DD + + S+ + + Sbjct: 351 VFQVKYSMDSKYIISGSDDGNVRLWRSKAWERSNVKTTREKNKLEY 396 Score = 97.2 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 44/315 (13%), Positives = 96/315 (30%), Gaps = 37/315 (11%) Query: 237 AHSGSVFGLTWSPDG-TKIASASADKTIKIWNVATLKVEKTIPVG----------TRIED 285 H V+ + + K+A+ SAD IK WN++T + + Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFH 124 Query: 286 QQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAIT----------------A 329 + + ++ ++S S + + + + N ++T Sbjct: 125 DKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQG 184 Query: 330 LSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDH 389 + S + T + A I+ WD++ IT +K S Sbjct: 185 IDSHRENSTFATGGA--KIHLWDVNRLKPVSDLSWGADN-ITSLKFNQNETDILASTGSD 241 Query: 390 LKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIY----SHGKLTEV 445 +V ++ + + + + V A H A Y + + V Sbjct: 242 NSIVLYDLRTNSPTQKIVQTMRTN-AICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNV 300 Query: 446 PISYNSSC--VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNG 503 + S+ V S + G D + +YK + E+ + V +S + Sbjct: 301 FKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQHVFQVKYSMDS 360 Query: 504 AFLVATDQSRKVIPY 518 ++++ V + Sbjct: 361 KYIISGSDDGNVRLW 375 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 16/77 (20%), Positives = 26/77 (33%), Gaps = 4/77 (5%) Query: 27 TPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQ---TTVAKTSPSGYYCASGDVHGNV 83 +P GD+I + + + + H+ + K S Y SG GNV Sbjct: 314 SPTGDEIVTGSYDKSIRIYKTNHGHSREIY-HTKRMQHVFQVKYSMDSKYIISGSDDGNV 372 Query: 84 RIWDTTQTTHILKTTIP 100 R+W + T Sbjct: 373 RLWRSKAWERSNVKTTR 389 Score = 40.2 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 18/89 (20%), Positives = 35/89 (39%), Gaps = 14/89 (15%) Query: 533 TFHTAKVACVSWSPDN-VRLATGSLDNSVIVWNMNKPSDHPIIIKGAH----AMSSVNSV 587 H V ++ + + +LATGS D + WNM+ + + AH V Sbjct: 64 YGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMS--TREEFVSFKAHYGLVTGLCVTQP 121 Query: 588 IWLN-------ETTIVSAGQDSNIKFWNV 609 + + + ++S D +K W++ Sbjct: 122 RFHDKKPDLKSQNFMLSCSDDKTVKLWSI 150 >3CFV-B nrPDB Length = 414 Score = 163 bits (411), Expect = 3e-40, Method: Composition-based stats. Identities = 50/277 (18%), Positives = 103/277 (37%), Gaps = 27/277 (9%) Query: 17 ARGTAVVLGNTPAGDKIQYCNGTS-VYTVPVGSLTDTEIYTEHSHQTTVAKTSPS-GYYC 74 + ++ TP+ D + + P G H + + + + Sbjct: 136 PQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHL 195 Query: 75 ASGDVHGNVRIWDTTQTTHILKTTIP-----VFSGPVKDISWDSESKRI-AAVGEGRERF 128 S V +WD K S V+D++W + + +V + + Sbjct: 196 LSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQ--- 252 Query: 129 GHVFLFDTGTS-----NGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKF- 182 + ++DT ++ + + +N + F P F + +GS D TVA+++ K Sbjct: 253 -KLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK 311 Query: 183 KSTFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV----- 236 TF H + V ++P + ++ AS+G D + +++ + ED Sbjct: 312 LHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFI 371 Query: 237 --AHSGSVFGLTWSPDGTK-IASASADKTIKIWNVAT 270 H+ + +W+P+ I S S D ++IW +A Sbjct: 372 HGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAE 408 Score = 128 bits (322), Expect = 5e-30, Method: Composition-based stats. Identities = 53/289 (18%), Positives = 110/289 (38%), Gaps = 44/289 (15%) Query: 102 FSGPVKDISWDSESKRIAAVGEGRERFGHVFLFD----------TGTSNG--NLTGQARA 149 G V + ++ I A + V +FD +G N L G + Sbjct: 125 HEGEVNRARYMPQNPHIIAT---KTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKE 181 Query: 150 MNSVDFKPSRPFRIISGSDDNTVAIFEGPPF-------KFKSTFGEHTKFVHSVRYN-PD 201 + + + ++S SDD+TV +++ K+ F H+ V V ++ Sbjct: 182 GYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLH 241 Query: 202 GSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGT-KIASASAD 260 SLF S D +++++ T++ S AH+ V L+++P +A+ SAD Sbjct: 242 ESLFGSVADDQKLMIWD----TRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSAD 297 Query: 261 KTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSIS-ANGFINFVNPEL------ 313 KT+ +W++ LK++ + E Q+ + +++ S + +N + Sbjct: 298 KTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQS 357 Query: 314 --------GSIDQVRYGHNKAITALSSSADGKT-LFSADAEGHINSWDI 353 + + GH I+ S + + + S + + W + Sbjct: 358 AEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 406 Score = 113 bits (281), Expect = 3e-25, Method: Composition-based stats. Identities = 44/252 (17%), Positives = 81/252 (32%), Gaps = 18/252 (7%) Query: 136 TGTSNGNLT-GQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKST--------- 185 TG + +N + P P I + + + V +F+ K Sbjct: 114 TGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDL 173 Query: 186 -FGEHTKFVHSVRYNPDGS-LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVF 243 H K + + +N + S S D T+ L++ G K G D HS V Sbjct: 174 RLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVE 233 Query: 244 GLTWS-PDGTKIASASADKTIKIWNVATLKVEKT--IPVGTRIEDQQLGIIWTKQAL-VS 299 + W + S + D+ + IW+ + K + E L + + + Sbjct: 234 DVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILAT 293 Query: 300 ISANGFINFVNPELGSI-DQVRYGHNKAITALSSSA-DGKTLFSADAEGHINSWDISTGI 357 SA+ + + + H I + S + L S+ + +N WD+S Sbjct: 294 GSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIG 353 Query: 358 SNRVFPDVHATM 369 + D Sbjct: 354 EEQSAEDAEDGP 365 Score = 92.2 bits (227), Expect = 5e-19, Method: Composition-based stats. Identities = 29/186 (15%), Positives = 55/186 (29%), Gaps = 17/186 (9%) Query: 54 IYTEHSHQTTVAKTSP-SGYYCASGDVHGNVRIWDTTQTTHILKTTI-PVFSGPVKDISW 111 I+T HS S + IWDT T + + + V +S+ Sbjct: 224 IFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSF 283 Query: 112 DSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNT 171 + S+ I A G + L + + V + P + S D Sbjct: 284 NPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRR 343 Query: 172 VAIFEGP--------------PFKFKSTFGEHTKFVHSVRYNPDGSLFA-STGGDGTIVL 216 + +++ P + G HT + +NP+ S D + + Sbjct: 344 LNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQI 403 Query: 217 YNGVDG 222 + + Sbjct: 404 WQMAEN 409 Score = 89.2 bits (219), Expect = 5e-18, Method: Composition-based stats. Identities = 57/328 (17%), Positives = 111/328 (33%), Gaps = 55/328 (16%) Query: 270 TLKVEKTIPVGTRIEDQQLGIIWTKQALVSI---SANGFINFVNPE--------LGSIDQ 318 T K+E I + E + + +++ S++ + + D Sbjct: 114 TGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDL 173 Query: 319 VRYGHNKAITALSSSAD-GKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTS 377 GH K LS +++ L SA + + WDI+ G Sbjct: 174 RLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAG-------------------PK 214 Query: 378 KGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIY 437 +G + K + G S V + L L +V+ D + + + Sbjct: 215 EGKIV------DAKAIFTGHSAVV-EDVAWHLLHES-LFGSVADDQKLMIWDTRSN--TT 264 Query: 438 SHGKLTEVPISYNSSCVALSNDKQFV-AVGGQDSKVHVYKLSGASVSEVKTIVHPAEITS 496 S + +C++ + +F+ A G D V ++ L + H EI Sbjct: 265 SKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQ 324 Query: 497 VAFSN-NGAFLVATDQSRKVIPYSVANNFELAHTN-----------SWTFHTAKVACVSW 544 V +S N L ++ R++ + ++ E HTAK++ SW Sbjct: 325 VHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSW 384 Query: 545 SPDNVR-LATGSLDNSVIVWNMNKPSDH 571 +P+ + + S DN + +W M + + Sbjct: 385 NPNEPWVICSVSEDNIMQIWQMAENIYN 412 Score = 81.8 bits (200), Expect = 8e-16, Method: Composition-based stats. Identities = 39/192 (20%), Positives = 78/192 (40%), Gaps = 19/192 (9%) Query: 428 AACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGA----SVS 483 C + + H K +S+NS+ + D V ++ ++ + Sbjct: 167 GECNPDLRLRGHQK-EGYGLSWNSNLSG------HLLSASDDHTVCLWDINAGPKEGKIV 219 Query: 484 EVKTI--VHPAEITSVAFSN-NGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVA 540 + K I H A + VA+ + + + +K++ + +N ++ HTA+V Sbjct: 220 DAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVN 279 Query: 541 CVSWSP-DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLN--ETTIVS 597 C+S++P LATGS D +V +W++ + + V W ET + S Sbjct: 280 CLSFNPYSEFILATGSADKTVALWDLRNLKLK--LHTFESHKDEIFQVHWSPHNETILAS 337 Query: 598 AGQDSNIKFWNV 609 +G D + W++ Sbjct: 338 SGTDRRLNVWDL 349 Score = 80.7 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 29/166 (17%), Positives = 62/166 (37%), Gaps = 19/166 (11%) Query: 461 QFVAVGGQDSKVHVYKL--SGASVSEVKTIVHPAEITSVAFSNNGAFLVA-TDQSRKVIP 517 D K+ ++ + S H AE+ ++F+ F++A + V Sbjct: 243 SLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 302 Query: 518 YSVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVWNMNKPSDH----- 571 + + N HT + H ++ V WSP + LA+ D + VW+++K + Sbjct: 303 WDLRNLKLKLHT--FESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAED 360 Query: 572 ------PIIIKGAHAMSSVNSVIWLNETTIV--SAGQDSNIKFWNV 609 ++ + ++ W V S +D+ ++ W + Sbjct: 361 AEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 406 >5XYI-g nrPDB Length = 335 Score = 162 bits (410), Expect = 4e-40, Method: Composition-based stats. Identities = 64/318 (20%), Positives = 117/318 (36%), Gaps = 34/318 (10%) Query: 275 KTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNP-----ELGSIDQVRYGHNKAITA 329 + VG + + I LVS S + + + GHN ++ Sbjct: 26 RATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSD 85 Query: 330 LSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKT-TSKGDLFTVSWDD 388 +S S D L ++ + + WD+ST + ++F H + G+ + +V D+ Sbjct: 86 VSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLG-HKKDVLGVTFSPCNRRIISVGRDN 144 Query: 389 HLKVVPAGG---------SGVDSSKAVANKLSSQPLGLAVSA-DGDIAVAACYKHIAIYS 438 +K+ G S V S + PL +AV DG + + +I Sbjct: 145 QVKIWNILGENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYI------WSIEK 198 Query: 439 HGKLTEVPISYNSSC--VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITS 496 KL + +++ C V + D ++V GG D KV ++ + + T P+ + + Sbjct: 199 EAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTA--PSPVHA 256 Query: 497 VAFSNNGAFLVAT-DQSRKVIPYSVANNFELAHTN------SWTFHTAKVACVSWSPDNV 549 VA A++ A + V +L N T C++W+ D Sbjct: 257 VAACPTQAWICAATYEGIAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADGS 316 Query: 550 RLATGSLDNSVIVWNMNK 567 L +G D S+ W + Sbjct: 317 VLYSGYNDGSIRAWEVKS 334 Score = 150 bits (378), Expect = 2e-36, Method: Composition-based stats. Identities = 59/320 (18%), Positives = 108/320 (33%), Gaps = 31/320 (9%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGP---VKDISW 111 + H+ + Y S + +W +T T G V D+S Sbjct: 29 FVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSL 88 Query: 112 DSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNT 171 ++ + + ++ T T+ G + + V F P RIIS DN Sbjct: 89 SRDASHLLTSS--WDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNR-RIISVGRDNQ 145 Query: 172 VAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGS-----LFASTGGDGTIVLYNGVDGTKTG 226 V I+ + +V SV P + A DG + +++ K Sbjct: 146 VKIWNILGENKAELQC--SSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEAKLI 203 Query: 227 VFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQ 286 + AH G + ++PDG + + +D+ + +W KTI Sbjct: 204 ------KEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGA--KTISFTAPSPVH 255 Query: 287 QLGIIWTKQALVSISANGF----------INFVNPELGSIDQVRYGHNKAITALSSSADG 336 + T+ + + + G I+ V P + G T L+ +ADG Sbjct: 256 AVAACPTQAWICAATYEGIAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADG 315 Query: 337 KTLFSADAEGHINSWDISTG 356 L+S +G I +W++ + Sbjct: 316 SVLYSGYNDGSIRAWEVKSA 335 Score = 90.3 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 42/231 (18%), Positives = 77/231 (33%), Gaps = 13/231 (5%) Query: 47 GSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPV 106 + T +++ H SP S V+IW+ + Sbjct: 110 STRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRDNQVKIWNILGENKAELQCSSWVTSVA 169 Query: 107 KDISWDSESKRIAAVGEGRERFGHVFLFDTGTS---NGNLTGQARAMNSVDFKPSRPFRI 163 D S + AVG G V+++ SVDF P + + Sbjct: 170 CAPMADETSPLVIAVG---CWDGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKW-V 225 Query: 164 ISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGT 223 I+G D V ++ +F VH+V P + + +G I +++ Sbjct: 226 ITGGSDRKVVMWLTENGAKTISFTA-PSPVHAVAACPTQAWICAATYEG-IAVWDIGAKQ 283 Query: 224 KTG----VFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT 270 + F+ + +N + L W+ DG+ + S D +I+ W V + Sbjct: 284 QIDLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWEVKS 334 Score = 82.2 bits (201), Expect = 6e-16, Method: Composition-based stats. Identities = 37/220 (16%), Positives = 83/220 (37%), Gaps = 16/220 (7%) Query: 395 AGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCV 454 A G +++ + ++ S D V + ++ + ++ S V Sbjct: 27 ATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDV 86 Query: 455 ALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRK 514 +LS D + DS + ++ LS + ++ + H ++ V FS +++ + + Sbjct: 87 SLSRDASHLLTSSWDSTLRLWDLSTRTTKKLF-LGHKKDVLGVTFSPCNRRIISVGRDNQ 145 Query: 515 VIPYSV--ANNFELAHTNSWTFHTAKVACVSWSPDNVR-----LATGSLDNSVIVWNMNK 567 V +++ N EL ++ V V+ +P +A G D V +W++ K Sbjct: 146 VKIWNILGENKAELQC-------SSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEK 198 Query: 568 PSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFW 607 + I AH + + +++ G D + W Sbjct: 199 EAK-LIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMW 237 Score = 77.6 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 28/123 (22%), Positives = 53/123 (43%), Gaps = 4/123 (3%) Query: 489 VHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHT--NSWTFHTAKVACVSWSP 546 H A I S+ N +LV+ + + + + + E T H V+ VS S Sbjct: 31 GHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLSR 90 Query: 547 DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKF 606 D L T S D+++ +W+++ + + + H + I+S G+D+ +K Sbjct: 91 DASHLLTSSWDSTLRLWDLSTRTTKKLFL--GHKKDVLGVTFSPCNRRIISVGRDNQVKI 148 Query: 607 WNV 609 WN+ Sbjct: 149 WNI 151 >5WBU-D nrPDB Length = 328 Score = 161 bits (408), Expect = 5e-40, Method: Composition-based stats. Identities = 53/308 (17%), Positives = 108/308 (35%), Gaps = 15/308 (4%) Query: 35 YCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHI 94 Y + + G T T + + Q + +P A+ +R++D Sbjct: 22 YDHTVRFWQAHSGICTRTVQHQD--SQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPN 78 Query: 95 LKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQ-ARAMNSV 153 + + + + + + + + G + ++ + Q +N V Sbjct: 79 PIISYDGVNKNIASVGFHEDGRWMYT--GGEDCTARIWDLRSRNLQCQRIFQVNAPINCV 136 Query: 154 DFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGT 213 P++ +I G + I++ + E + S +PD S A+ G Sbjct: 137 CLHPNQA-ELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGN 195 Query: 214 IVLYNGVDGTKTGVFE-DDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLK 272 ++N G V + K AH+ +SPD T +A+ SAD+T KIW + Sbjct: 196 CYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFS 255 Query: 273 VEKTIPVGTRIEDQQ-------LGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNK 325 + + + + + Q +V+ S++ E G I + GH K Sbjct: 256 LMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQK 315 Query: 326 AITALSSS 333 A+ L+ + Sbjct: 316 AVVCLAFN 323 Score = 122 bits (306), Expect = 4e-28, Method: Composition-based stats. Identities = 48/350 (13%), Positives = 114/350 (32%), Gaps = 45/350 (12%) Query: 158 SRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLY 217 S P + + D+TV ++ T V+++ PD S+ A+ G I +Y Sbjct: 12 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMY 70 Query: 218 NGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTI 277 + + D + ++ + + DG + + D T +IW++ + ++ Sbjct: 71 DLNSNNPNPIISYD-----GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQR 125 Query: 278 PVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGK 337 + + + L+ +G I+ + + +Q+ +IT+ D Sbjct: 126 IFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDAS 185 Query: 338 TLFSADAEGHINSWDISTGISN-------RVFPDVHATMITGIKTTSKGDLFTVSWDDHL 390 + + ++ G+ W+++ GI + + H + + L D Sbjct: 186 YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQT 245 Query: 391 KVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYN 450 + + + ++I S G E + Sbjct: 246 CKIWRTSNF-----------------------------SLMTELSIKS-GNPGESSRGWM 275 Query: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFS 500 C A S D Q++ D+ ++ + + H + +AF+ Sbjct: 276 WGC-AFSGDSQYIVTASSDNLARLWCVETGEIKREYG-GHQKAVVCLAFN 323 Score = 115 bits (287), Expect = 6e-26, Method: Composition-based stats. Identities = 44/295 (14%), Positives = 102/295 (34%), Gaps = 22/295 (7%) Query: 331 SSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHL 390 + +D L +A + + W +GI R + + ++ T + + H+ Sbjct: 9 TVGSDPVILATAGYDHTVRFWQAHSGICTRTV-QHQDSQVNALEVTPDRSMIAAAGYQHI 67 Query: 391 KVVPAGGSGVDSSKAV------ANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTE 444 ++ + + + + G + G+ A + + Sbjct: 68 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARI-WDLRSRNLQCQRI 126 Query: 445 VPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGA 504 ++ +CV L ++ + VG Q +H++ L ++ + ITS + + Sbjct: 127 FQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVS-ITSAHIDPDAS 185 Query: 505 FLVATDQSRKVIPYSVANNF-----ELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNS 559 ++ A + + +++ +L HT +SPD+ LAT S D + Sbjct: 186 YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQT 245 Query: 560 VIVWNMNKPSDHPIIIKGAHAMSSVNSVIWL-------NETTIVSAGQDSNIKFW 607 +W + S + + +S W+ + IV+A D+ + W Sbjct: 246 CKIWRTSNFSLMTELSIKSGNPGE-SSRGWMWGCAFSGDSQYIVTASSDNLARLW 299 Score = 109 bits (272), Expect = 3e-24, Method: Composition-based stats. Identities = 43/303 (14%), Positives = 95/303 (31%), Gaps = 26/303 (8%) Query: 115 SKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAI 174 S + G + + +G + Q +N+++ P R +G + Sbjct: 12 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYD 71 Query: 175 FEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNG--VDGTKTGVFEDDS 232 ++ K + SV ++ DG + G D T +++ + +F+ ++ Sbjct: 72 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA 131 Query: 233 LKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW 292 + + P+ ++ I IW++ T E+ IP + I Sbjct: 132 --------PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEP-EVSITSAHIDP 182 Query: 293 TKQALVSISANGFINFVNPELGSIDQVRY--------GHNKAITALSSSADGKTLFSADA 344 + ++++ G N G D+V H + S D L + A Sbjct: 183 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA 242 Query: 345 EGHINSW-----DISTGISNRVFPDVH--ATMITGIKTTSKGDLFTVSWDDHLKVVPAGG 397 + W + T +S + + G + + D+L + Sbjct: 243 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 302 Query: 398 SGV 400 +G Sbjct: 303 TGE 305 Score = 98.0 bits (242), Expect = 9e-21, Method: Composition-based stats. Identities = 42/309 (13%), Positives = 90/309 (29%), Gaps = 20/309 (6%) Query: 293 TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 L + + + F G + + + AL + D + +A + HI +D Sbjct: 13 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMYD 71 Query: 353 ISTGISNRVF-PDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLS 411 +++ N + D I + G +D + S + + + Sbjct: 72 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA 131 Query: 412 SQPLGLAVSADGDIAVAACYKHIAIYS----HGKLTEVPISYNSSCVALSNDKQFVAVGG 467 ++ V I I+ H + + + + D ++A Sbjct: 132 PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVN 191 Query: 468 QDSKVHVYKLSGA-------SVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPY-- 518 +V+ L+G + + K H FS + L + + Sbjct: 192 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRT 251 Query: 519 ---SVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIII 575 S+ + N + ++S D+ + T S DN +W + Sbjct: 252 SNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKR--E 309 Query: 576 KGAHAMSSV 584 G H + V Sbjct: 310 YGGHQKAVV 318 Score = 61.4 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 21/150 (14%), Positives = 43/150 (28%), Gaps = 8/150 (5%) Query: 15 RTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYC 74 A + + N T V L H+ + SP Sbjct: 178 AHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLL 237 Query: 75 ASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKD------ISWDSESKRIAAVGEGRERF 128 A+ +IW T+ + + + +I + ++ +S+ I Sbjct: 238 ATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSD--NL 295 Query: 129 GHVFLFDTGTSNGNLTGQARAMNSVDFKPS 158 ++ +TG G +A+ + F S Sbjct: 296 ARLWCVETGEIKREYGGHQKAVVCLAFNDS 325 Score = 49.9 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 14/109 (12%), Positives = 40/109 (36%), Gaps = 4/109 (3%) Query: 501 NNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSV 560 ++ L V + + T + ++V + +PD +A + Sbjct: 12 SDPVILATAGYDHTVRFWQAHSGI---CTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHI 67 Query: 561 IVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 ++++N + +PII + + + + + G+D + W++ Sbjct: 68 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL 116 >5K1B-B nrPDB Length = 677 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 72/423 (17%), Positives = 130/423 (30%), Gaps = 40/423 (9%) Query: 124 GRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFK-- 181 GR + ++ N G +N++ P+ R+ + D+ + I+ K Sbjct: 11 GRRKVQVSYVIRDEVEKYNRNG----VNALQLDPALN-RLFTAGRDSIIRIWSVNQHKQD 65 Query: 182 -FKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSG 240 + ++ HT +V+ + +G S D T+ ++N G H Sbjct: 66 PYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRT-------HKD 118 Query: 241 SVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIP--------VGTRIEDQQLGIIW 292 V L ++ D +ASA D+ I +W+V TL G + L + Sbjct: 119 YVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQ 178 Query: 293 TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 +VS S + +P + GH + AL + DG S ++G I W Sbjct: 179 LGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWS 238 Query: 353 ISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSS 412 + + VH + ++ D + K Sbjct: 239 LGQQRCIATYR-VHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPV 297 Query: 413 QPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKV 472 + L SAD AI+ + V L F A G D+ Sbjct: 298 LKMELDRSAD---------PPPAIWVATTKSTVNKW------TLKGIHNFRASGDYDNDC 342 Query: 473 HVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSW 532 ++ + I A I N+ ++ D + V + V ++ Sbjct: 343 -TNPITPLCTQPDQVIKGGASIIQCHILNDKRHILTKDTNNNVAYWDVLKACKVEDLGKV 401 Query: 533 TFH 535 F Sbjct: 402 DFE 404 Score = 120 bits (301), Expect = 2e-27, Method: Composition-based stats. Identities = 52/393 (13%), Positives = 120/393 (30%), Gaps = 36/393 (9%) Query: 62 TTVAKTSPSGYYCASGDVHGNVRIWDTTQTTH-ILKTTIPVFSGPVKDISWDSESKRIAA 120 + P+ + +RIW Q ++ + V DI K + + Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLIS 92 Query: 121 VGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPF 180 V+ G L + ++ + + + S D + +++ Sbjct: 93 ASSDT--TVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKEL-VASAGLDRQIFLWDVNTL 149 Query: 181 KFKS---------TFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDD 231 + + + ++S+ N G++ S + + +++ K + Sbjct: 150 TALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLK-- 207 Query: 232 SLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGII 291 H+ +V L + DGT+ S S+D TI++W++ + T V L + Sbjct: 208 -----GHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRV-HDEGVWALQVN 261 Query: 292 WTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 + S + I + I + + + A+ W Sbjct: 262 DAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDR--------SADPPPAIW 313 Query: 352 DISTGISNR--VFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANK 409 +T + +H +G + T +V+ G S + + Sbjct: 314 VATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQC-----HI 368 Query: 410 LSSQPLGLAVSADGDIAVAACYKHIAIYSHGKL 442 L+ + L + ++A K + GK+ Sbjct: 369 LNDKRHILTKDTNNNVAYWDVLKACKVEDLGKV 401 Score = 108 bits (268), Expect = 1e-23, Method: Composition-based stats. Identities = 55/397 (13%), Positives = 119/397 (29%), Gaps = 38/397 (9%) Query: 191 KFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD 250 V++++ +P + + G D I +++ + H+ V + + Sbjct: 31 NGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIA----SMEHHTDWVNDIVLCCN 86 Query: 251 GTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVN 310 G + SAS+D T+K+WN T+ + + L K+ + S + I + Sbjct: 87 GKTLISASSDTTVKVWNAHKGFCMSTLRT-HKDYVKALAYAKDKELVASAGLDRQIFLWD 145 Query: 311 PELGSIDQ---------VRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRV 361 + G+ +I +L+ + G + S E + WD T Sbjct: 146 VNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMK 205 Query: 362 FPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSA 421 H + + G D + + G + G+ Sbjct: 206 LKG-HTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQ-----QRCIATYRVHDEGVW--- 256 Query: 422 DGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGAS 481 A+ +YS G+ ++ C L N V + + + V +L ++ Sbjct: 257 ----ALQVNDAFTHVYSGGRDRKIY------CTDLRNPDIRVLICEEKAPVLKMELDRSA 306 Query: 482 VSE--VKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKV 539 + + + F + D + + + Sbjct: 307 DPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCT--NPITPLCTQPDQVIKGGASII 364 Query: 540 ACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIK 576 C + D + T +N+V W++ K + K Sbjct: 365 QCHILN-DKRHILTKDTNNNVAYWDVLKACKVEDLGK 400 Score = 97.6 bits (241), Expect = 2e-20, Method: Composition-based stats. Identities = 50/342 (14%), Positives = 98/342 (28%), Gaps = 51/342 (14%) Query: 31 DKIQYCNGTSVYTVPVGSLTDTE---------IYTEHSHQTTVAKTSPSGYYCASGDVHG 81 D + CNG ++ + + H + AS + Sbjct: 80 DIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDR 139 Query: 82 NVRIWDTTQTTH-------ILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLF 134 + +WD T + +++ + ++ + I V E+ V+ Sbjct: 140 QIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTII--VSGSTEKVLRVWDP 197 Query: 135 DTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVH 194 T L G + ++ + SGS D T+ ++ + +T+ H + V Sbjct: 198 RTCAKLMKLKGHTDNVKALLLNRDGTQCL-SGSSDGTIRLWSLGQQRCIATYRVHDEGVW 256 Query: 195 SVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG--- 251 +++ N + S G D I + + D + V + Sbjct: 257 ALQVNDAFTHVYSGGRDRKIYCTDLRN-------PDIRVLICEEKAPVLKMELDRSADPP 309 Query: 252 TKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNP 311 I A+ T+ W TLK ++ I P Sbjct: 310 PAIWVATTKSTVNKW---TLKGIHNFRASGDYDNDCTNPIT------------------P 348 Query: 312 ELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 DQV G I D + + + D ++ WD+ Sbjct: 349 LCTQPDQVIKGGASIIQC-HILNDKRHILTKDTNNNVAYWDV 389 Score = 84.9 bits (208), Expect = 1e-16, Method: Composition-based stats. Identities = 32/241 (13%), Positives = 83/241 (34%), Gaps = 17/241 (7%) Query: 376 TSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIA 435 T+ VS+ +V +GV++ + D I + + +H Sbjct: 9 TAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNR----LFTAGRDSIIRIWSVNQHKQ 64 Query: 436 IYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEIT 495 + N + + + + D+ V V+ H + Sbjct: 65 DPYIASMEHHTDWVNDIVLCCN--GKTLISASSDTTVKVWNAHKGFCMSTLRT-HKDYVK 121 Query: 496 SVAFSNNGAFLVATDQSRKVIPYSVANNFEL------AHTNSWTFHTAKVACVSWSPDNV 549 ++A++ + + + R++ + V L T+S + + + ++ + Sbjct: 122 ALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGT 181 Query: 550 RLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWL-NETTIVSAGQDSNIKFWN 608 + +GS + + VW+ P ++K +V +++ + T +S D I+ W+ Sbjct: 182 IIVSGSTEKVLRVWD---PRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWS 238 Query: 609 V 609 + Sbjct: 239 L 239 >6J6H-n nrPDB Length = 455 Score = 160 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 62/306 (20%), Positives = 120/306 (39%), Gaps = 57/306 (18%) Query: 140 NGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFE-GPPFKFKSTFGEHTKFVHSVRY 198 N G ++ F P I+SG +D+T+ I++ ++ F H K + ++R+ Sbjct: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRF 214 Query: 199 NPDGSLFASTGGDGTIVLYNGVDG-------------------------------TKTGV 227 D F S+ D ++ +++ G +K Sbjct: 215 TEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILH 274 Query: 228 FEDDSLKNVA-------HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVG 280 ++D +N H S+ L + PDG+K S+S DKT++IW K I Sbjct: 275 YDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDT 334 Query: 281 TRIEDQQLGIIWTKQALVSISANGFI--NFVNPELG-SIDQVRYGHNKAIT--ALSSSAD 335 + L + ++ + S + I + P+ ++ GH+ A +L+ S D Sbjct: 335 AQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGD 394 Query: 336 GKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSW--DDHLKVV 393 G+ + S D++ + +WD +T + ++ IK + V W + KV+ Sbjct: 395 GRYICSGDSKSRLFTWDWNT-----------SRLLNNIKIPGNKPITQVDWHPQETSKVI 443 Query: 394 PAGGSG 399 +G +G Sbjct: 444 CSGAAG 449 Score = 122 bits (305), Expect = 5e-28, Method: Composition-based stats. Identities = 53/342 (15%), Positives = 116/342 (33%), Gaps = 49/342 (14%) Query: 179 PFKFKSTFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVLYN-GVDGTKTGVFEDDSLKNV 236 P K + H + ++++ P G L S G D TI +++ D F+ Sbjct: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQ------- 203 Query: 237 AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA 296 H+ + L ++ D S+S D+++KIW+ T KV+ + + + D + + Sbjct: 204 GHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEF 263 Query: 297 LVSISANGFINFVN--PELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIS 354 +V +S + +++ + E + Q H +I AL DG S+ + + W+ Sbjct: 264 IVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQ 323 Query: 355 TGISNRVFPDVHATMITGIKTTSKGDLFTV-SWDDHLKVVPAGGSGVDSSKAVANKLSSQ 413 + + D + + + F S D+ + ++ K Sbjct: 324 INVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSF-----------SLKPKYKRH 372 Query: 414 PLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVH 473 P + + +A S D +++ G S++ Sbjct: 373 PKKIF------------------------KGHSSAGYGISLAFSGDGRYICSGDSKSRLF 408 Query: 474 VYKLSGASVSEVKTIVHPAEITSVAFSN--NGAFLVATDQSR 513 + + + + I IT V + + + + Sbjct: 409 TWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGK 450 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 38/313 (12%), Positives = 95/313 (30%), Gaps = 15/313 (4%) Query: 307 NFVNPELGSIDQVRYGHNKAITALSSSAD-GKTLFSADAEGHINSWDISTGISNRVFPDV 365 P+ + + GH + TAL G + S + I WD Sbjct: 147 RCYLPK--KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQG 204 Query: 366 HATMITGIKTT-SKGDLFTVSWDDHLKVVPAGGSGVDS---SKAVANKLSSQPLG--LAV 419 H I ++ T + S+D +K+ V + + + S+P + Sbjct: 205 HNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFI 264 Query: 420 SADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSG 479 + + ++ T + + D +D V +++ Sbjct: 265 VGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQI 324 Query: 480 ASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTA-- 537 + + + + + + A ++ +S+ ++ + H++ Sbjct: 325 NVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAG 384 Query: 538 KVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT--I 595 +++S D + +G + + W+ N I + + V W + T + Sbjct: 385 YGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKP--ITQVDWHPQETSKV 442 Query: 596 VSAGQDSNIKFWN 608 + +G I + Sbjct: 443 ICSGAAGKIYVCD 455 Score = 97.2 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 47/303 (15%), Positives = 91/303 (30%), Gaps = 17/303 (5%) Query: 7 TALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEI---YTEHSHQTT 63 + + P GT L P + G D E + H+ Sbjct: 152 KKVIRNYPGHPEGTTA-LKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIK 210 Query: 64 VAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGE 123 + + S +V+IWDT + + V+ + + I + Sbjct: 211 ALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNP-HEFIVGLSN 269 Query: 124 GRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFK 183 + + + ++ ++ + P + IS S+D TV I+E Sbjct: 270 SKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGS-KFISSSEDKTVRIWENQINVPI 328 Query: 184 STFG---EHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSG 240 +H+ +V +P + F + D I K HS Sbjct: 329 KQISDTAQHSMPFLNV--HPSQNYFCAQSMDNRI----YSFSLKPKYKRHPKKIFKGHSS 382 Query: 241 SVF--GLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALV 298 + + L +S DG I S + + W+ T ++ I + Q+ + + V Sbjct: 383 AGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKV 442 Query: 299 SIS 301 S Sbjct: 443 ICS 445 Score = 47.2 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 25/174 (14%), Positives = 56/174 (32%), Gaps = 22/174 (12%) Query: 16 TARGTAVVLGNTPAGDKIQYCNGTS-------VYTVPVGSLTDTEIYTEHSHQTTVAKTS 68 + + L P G K + VP+ ++DT H Sbjct: 291 HHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQ-----HSMPFLNVH 345 Query: 69 PSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVK-----DISWDSESKRIAAVGE 123 PS Y + + RI+ + + +F G +++ + + I G+ Sbjct: 346 PSQNYFCAQSMDN--RIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYI-CSGD 402 Query: 124 GRERFGHVFLFDTGTSNGNLT-GQARAMNSVDFKPSRPFRIISGSDDNTVAIFE 176 + R + ++T N+ + + VD+ P ++I + + + Sbjct: 403 SKSRLFT-WDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 >6ID0-T nrPDB Length = 514 Score = 158 bits (400), Expect = 6e-39, Method: Composition-based stats. Identities = 63/351 (17%), Positives = 111/351 (31%), Gaps = 31/351 (8%) Query: 12 SLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYT----EHSHQTTVAKT 67 P + GNT + T+P H Sbjct: 157 PQPTAMNSIVMETGNTKNSALMA----KKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAV 212 Query: 68 SPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRER 127 P + +G ++IWD LK ++ V+ + + S + + GE ++ Sbjct: 213 EPGNQWFVTGSADRTIKIWDLASGK--LKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQV 270 Query: 128 FGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFG 187 + + + G A+ +D P+ +++ S D+T I++ T Sbjct: 271 KC--WDLEYNKVIRHYHGHLSAVYGLDLHPTI-DVLVTCSRDSTARIWDVRTKASVHTLS 327 Query: 188 EHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW 247 HT V +VR + D TI L++ V G + H SV + Sbjct: 328 GHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTN-------HKKSVRAVVL 380 Query: 248 SPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFIN 307 P AS S D IK W + + I + + + LVS + NG ++ Sbjct: 381 HPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLT--VNSDGVLVSGADNGTMH 437 Query: 308 FVNPELGSIDQVRYG--------HNKAITALSSSADGKTLFSADAEGHINS 350 + G Q + I A + L +A+A+ I Sbjct: 438 LWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKV 488 Score = 153 bits (387), Expect = 2e-37, Method: Composition-based stats. Identities = 53/322 (16%), Positives = 103/322 (31%), Gaps = 19/322 (5%) Query: 137 GTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSV 196 ++G + + +P + ++GS D T+ I++ K K + H V V Sbjct: 194 WKLYRVISGHLGWVRCIAVEPGNQW-FVTGSADRTIKIWDLASGKLKLSLTGHISTVRGV 252 Query: 197 RYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIAS 256 + S G D + ++ + H +V+GL P + + Sbjct: 253 IVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYH-------GHLSAVYGLDLHPTIDVLVT 305 Query: 257 ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSI 316 S D T +IW+V T T+ G + + +++ S + I + G Sbjct: 306 CSRDSTARIWDVRTKASVHTLS-GHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKT 364 Query: 317 DQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTT 376 H K++ A+ T S + I W G + H +I + Sbjct: 365 RVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSG-HNAIINTLTVN 422 Query: 377 SKGDLFTVSWDDHLKVVPAGGSGVD------SSKAVANKLSSQPLGLAV-SADGDIAVAA 429 S G + D+ + +G + + + + S A ++ + A Sbjct: 423 SDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAE 481 Query: 430 CYKHIAIYSHGKLTEVPISYNS 451 K I +Y S Sbjct: 482 ADKTIKVYREDDTATEETHPVS 503 Score = 148 bits (373), Expect = 6e-36, Method: Composition-based stats. Identities = 46/231 (19%), Positives = 85/231 (36%), Gaps = 8/231 (3%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSE 114 Y H P+ + RIWD T T+ + V + + Sbjct: 284 YHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV--RTKASVHTLSGHTNAVATVRCQAA 341 Query: 115 SKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAI 174 +I ++ G + LT +++ +V P + SGS DN + Sbjct: 342 EPQIITGSHDT--TIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRH-YTFASGSPDN-IKQ 397 Query: 175 FEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDG-TKTGVFEDDSL 233 ++ P F H ++++ N DG + S +GT+ L++ G V Sbjct: 398 WKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQP 456 Query: 234 KNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIE 284 ++ +F + +++ +A ADKTIK++ E+T PV + E Sbjct: 457 GSLDSESGIFACAFDQSESRLLTAEADKTIKVYREDDTATEETHPVSWKPE 507 Score = 135 bits (340), Expect = 4e-32, Method: Composition-based stats. Identities = 56/348 (16%), Positives = 107/348 (30%), Gaps = 57/348 (16%) Query: 178 PPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 PP+K H +V + P F + D TI +++ G L Sbjct: 192 PPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKL-------KLSLTG 244 Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQAL 297 H +V G+ S + S DK +K W++ KV + G L + T L Sbjct: 245 HISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIR-HYHGHLSAVYGLDLHPTIDVL 303 Query: 298 VSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGI 357 V+ S + + + GH A+ + A + + + I WD+ G Sbjct: 304 VTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGK 363 Query: 358 SNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGL 417 + RV H + + + F D++K Sbjct: 364 T-RVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWK-----------------FPDGSF 405 Query: 418 AVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKL 477 + G A+ + + +++D + G + +H++ Sbjct: 406 IQNLSGHNAI-----------------------INTLTVNSDG-VLVSGADNGTMHLWDW 441 Query: 478 SGASVSE-VKTIVHPAE------ITSVAFSNNGAFLVATDQSRKVIPY 518 + V V P I + AF + + L+ + + + Y Sbjct: 442 RTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 53/332 (15%), Positives = 109/332 (32%), Gaps = 49/332 (14%) Query: 237 AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA 296 H G V + P + SAD+TIKIW++A+ K++ ++ G + + + Sbjct: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSL-TGHISTVRGVIVSTRSPY 260 Query: 297 LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 L S + + + E + + +GH A+ L L + + WD+ T Sbjct: 261 LFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTK 320 Query: 357 ISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLG 416 S + T ++ + T S D +++ Sbjct: 321 ASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVA------------------- 361 Query: 417 LAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYK 476 G V + +H K V L A G D+ + +K Sbjct: 362 ------GKTRVT-------LTNHKKS--------VRAVVLHPRHYTFASGSPDN-IKQWK 399 Query: 477 LSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNS----- 531 S + + H A I ++ +++G LV+ + + + + ++ Sbjct: 400 FPDGSFIQNLS-GHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPG 457 Query: 532 WTFHTAKVACVSWSPDNVRLATGSLDNSVIVW 563 + + ++ RL T D ++ V+ Sbjct: 458 SLDSESGIFACAFDQSESRLLTAEADKTIKVY 489 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 29/178 (16%), Positives = 73/178 (41%), Gaps = 7/178 (3%) Query: 432 KHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHP 491 + + ++ + + C+A+ Q+ G D + ++ L+ + T H Sbjct: 189 QWHPPWKLYRVISGHLGW-VRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLT-GHI 246 Query: 492 AEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRL 551 + + V S +L + + ++V + + N + H + H + V + P L Sbjct: 247 STVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRH---YHGHLSAVYGLDLHPTIDVL 303 Query: 552 ATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 T S D++ +W++ + + +A+++V E I++ D+ I+ W++ Sbjct: 304 VTCSRDSTARIWDVRTKASVHTLSGHTNAVATVR--CQAAEPQIITGSHDTTIRLWDL 359 Score = 98.0 bits (242), Expect = 1e-20, Method: Composition-based stats. Identities = 38/217 (17%), Positives = 69/217 (31%), Gaps = 26/217 (11%) Query: 413 QPLGLAVSADGDIAVAAC---------------YKHIAIYSHG----KLTEVPISYNSSC 453 P L G + C + I I+ KL+ Sbjct: 192 PPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRG 251 Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSR 513 V +S ++ G+D +V + L V H + + + LV + Sbjct: 252 VIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHY-HGHLSAVYGLDLHPTIDVLVTCSRDS 310 Query: 514 KVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPI 573 + V + + + HT VA V ++ TGS D ++ +W++ Sbjct: 311 TARIWDVRTKASVH---TLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVT 367 Query: 574 IIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNVP 610 + + SV +V+ ++G NIK W P Sbjct: 368 LT---NHKKSVRAVVLHPRHYTFASGSPDNIKQWKFP 401 Score = 66.0 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 16/82 (19%), Positives = 34/82 (41%), Gaps = 2/82 (2%) Query: 530 NSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW 589 + H V C++ P N TGS D ++ +W++ + + V ++ Sbjct: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGV--IVS 255 Query: 590 LNETTIVSAGQDSNIKFWNVPF 611 + S G+D +K W++ + Sbjct: 256 TRSPYLFSCGEDKQVKCWDLEY 277 >4LG8-A nrPDB Length = 354 Score = 158 bits (399), Expect = 6e-39, Method: Composition-based stats. Identities = 46/261 (17%), Positives = 99/261 (37%), Gaps = 15/261 (5%) Query: 150 MNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTG 209 + ++D PS +I++G D V +F+ + +T HTK V SV ++P L S Sbjct: 74 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSAS 133 Query: 210 GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVA 269 D TI +++ + + V AH +V GL+ G + S+S D + W + Sbjct: 134 PDATIRIWSVPNASCVQVVR-------AHESAVTGLSLHATGDYLLSSSDD---QYWAFS 183 Query: 270 TLKVEKTIPVGTRIED----QQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNK 325 ++ + + T + + + I + + + GH+ Sbjct: 184 DIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSG 243 Query: 326 AITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTV- 384 IT+++ S +G L +A + + WD+ + + + + + G + Sbjct: 244 PITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALG 303 Query: 385 SWDDHLKVVPAGGSGVDSSKA 405 D + + + ++ Sbjct: 304 GTDVQIYICKQWTEILHFTEH 324 Score = 139 bits (350), Expect = 3e-33, Method: Composition-based stats. Identities = 38/266 (14%), Positives = 82/266 (30%), Gaps = 16/266 (6%) Query: 47 GSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPV 106 S H+ + T PS S +RIW + V Sbjct: 102 SSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPN--ASCVQVVRAHESAV 159 Query: 107 KDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQAR--AMNSVDFKPSRPFRII 164 +S + + + + + + TG +T + ++ F P Sbjct: 160 TGLSLHATGDYLLSSSDDQ--YWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPD-GLIFG 216 Query: 165 SGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTK 224 +G+ D+ + I++ + F H+ + S+ ++ +G A+ D ++ L++ Sbjct: 217 TGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKN 276 Query: 225 TGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIE 284 + D+ + V L + GT +A D I I E Sbjct: 277 FKTLQLDN------NFEVKSLIFDQSGTYLALGGTDVQIYI---CKQWTEILHFTEHSGL 327 Query: 285 DQQLGIIWTKQALVSISANGFINFVN 310 + + + S + + F + Sbjct: 328 TTGVAFGHHAKFIASTGMDRSLKFYS 353 Score = 131 bits (329), Expect = 8e-31, Method: Composition-based stats. Identities = 49/285 (17%), Positives = 97/285 (34%), Gaps = 56/285 (19%) Query: 113 SESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTV 172 S++ +I G + VF + L G + + SV F PS+ + S S D T+ Sbjct: 82 SDTNKILTGGADKNVV--VFDKSSEQILATLKGHTKKVTSVVFHPSQDL-VFSASPDATI 138 Query: 173 AIFEGPPFKFKSTFGEHTKFV--------------------------------------- 193 I+ P H V Sbjct: 139 RIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDET 198 Query: 194 -----HSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 +++PDG +F + D I +++ + T F HSG + + +S Sbjct: 199 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFP-------GHSGPITSIAFS 251 Query: 249 PDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINF 308 +G +A+A+ D ++K+W++ LK KT+ + E + L + L + + Sbjct: 252 ENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD--VQI 309 Query: 309 VNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 + + H+ T ++ K + S + + + + Sbjct: 310 YICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 354 Score = 120 bits (300), Expect = 2e-27, Method: Composition-based stats. Identities = 50/278 (17%), Positives = 99/278 (35%), Gaps = 11/278 (3%) Query: 293 TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 +++ A+ + + I GH K +T++ +FSA + I W Sbjct: 83 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 142 Query: 353 ISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSS 412 + +V H + +TG+ + GD S DD +G +K Sbjct: 143 VPNASCVQVVR-AHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 201 Query: 413 QPLGLAVSADGDI-AVAACYKHIAIYSHGKLTEV----PISYNSSCVALSNDKQFVAVGG 467 DG I I I+ + T V S + +A S + ++A Sbjct: 202 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAA 261 Query: 468 QDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELA 527 DS V ++ L + + + E+ S+ F +G +L ++ E+ Sbjct: 262 DDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYI--CKQWTEIL 319 Query: 528 HTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM 565 H +T H+ V++ +A+ +D S+ +++ Sbjct: 320 H---FTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 354 Score = 89.9 bits (221), Expect = 3e-18, Method: Composition-based stats. Identities = 26/159 (16%), Positives = 67/159 (42%), Gaps = 4/159 (2%) Query: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATD 510 + V + V D+ + ++ + AS +V H + +T ++ G +L+++ Sbjct: 117 VTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQV-VRAHESAVTGLSLHATGDYLLSSS 175 Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 + + L T + + C + PD + TG++D+ + +W++ + ++ Sbjct: 176 DDQYWAFSDIQTGRVLTKVTDETSGCS-LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN 234 Query: 571 HPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 + H+ + N + +A DS++K W++ Sbjct: 235 --VANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDL 271 Score = 81.5 bits (199), Expect = 9e-16, Method: Composition-based stats. Identities = 43/290 (14%), Positives = 93/290 (32%), Gaps = 53/290 (18%) Query: 325 KAITALSSSA-DGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDL-F 382 I AL D + + A+ ++ +D S+ H +T + DL F Sbjct: 72 PGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKG-HTKKVTSVVFHPSQDLVF 130 Query: 383 TVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKL 442 + S D +++ + A+C + + Sbjct: 131 SASPDATIRIW------------------------------SVPNASCVQVVR------- 153 Query: 443 TEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPA-EITSVAFSN 501 + ++L ++ D + V T +T F Sbjct: 154 ---AHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP 210 Query: 502 NGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVI 561 +G ++ + + +A ++ H+ + +++S + LAT + D+SV Sbjct: 211 DGLIFGTGTMDSQIKIWDLKERTNVA---NFPGHSGPITSIAFSENGYYLATAADDSSVK 267 Query: 562 VWNMNKPSDHPIIIKGAHAMSSVNSVIWL-NETTIVSAGQDSNI---KFW 607 +W++ K + + + V S+I+ + T + G D I K W Sbjct: 268 LWDLRKLKNFKTLQLDNNFE--VKSLIFDQSGTYLALGGTDVQIYICKQW 315 Score = 61.8 bits (148), Expect = 7e-10, Method: Composition-based stats. Identities = 23/123 (18%), Positives = 44/123 (35%), Gaps = 6/123 (4%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSE 114 + HS T S +GYY A+ +V++WD + + + + VK + +D Sbjct: 238 FPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLD-NNFEVKSLIFDQS 296 Query: 115 SKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAI 174 +A G +++ T + T + V F I S D ++ Sbjct: 297 GTYLALGGTD----VQIYICKQWTEILHFTEHSGLTTGVAFG-HHAKFIASTGMDRSLKF 351 Query: 175 FEG 177 + Sbjct: 352 YSL 354 Score = 48.7 bits (114), Expect = 8e-06, Method: Composition-based stats. Identities = 18/73 (24%), Positives = 35/73 (47%), Gaps = 3/73 (4%) Query: 539 VACVSWSP-DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVS 597 + + P D ++ TG D +V+V++ K S+ + H + V ++ + S Sbjct: 74 ILALDLCPSDTNKILTGGADKNVVVFD--KSSEQILATLKGHTKKVTSVVFHPSQDLVFS 131 Query: 598 AGQDSNIKFWNVP 610 A D+ I+ W+VP Sbjct: 132 ASPDATIRIWSVP 144 >3JAP-g nrPDB Length = 326 Score = 158 bits (398), Expect = 8e-39, Method: Composition-based stats. Identities = 70/326 (21%), Positives = 119/326 (36%), Gaps = 34/326 (10%) Query: 53 EIYTEHSHQTTVAKTSPSG-YYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGP---VKD 108 H+ T TS + SG + W T+ + + G V+D Sbjct: 12 GTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQD 71 Query: 109 ISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSD 168 + ++ AV ++ ++ TG S G + SV + +IIS S Sbjct: 72 VVVSADGNY--AVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAID-ANSSKIISASR 128 Query: 169 DNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNP---------DGSL-FASTGGDGTIVLYN 218 D T+ ++ HT +V VR P DG + F S G D + ++ Sbjct: 129 DKTIRVWN-TVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWS 187 Query: 219 GVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIP 278 + + + H+ + + SPDG+ ASA D I +WN+ Sbjct: 188 LNEDS-----YRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFD 242 Query: 279 VGTRIEDQQLGIIWTKQALVSISANGFINFVNPEL----GSIDQVRYGHNKA----ITAL 330 + E L ++ L + +A+G I + E + G+ KA +L Sbjct: 243 A--KDEVFALAFSPSRFWLTAATASG-IKIYDLENEVLIDELKPEFAGYTKAQDPHAVSL 299 Query: 331 SSSADGKTLFSADAEGHINSWDISTG 356 + SADG+TLF+ + I W + T Sbjct: 300 AWSADGQTLFAGYTDNVIRVWQVMTA 325 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 59/293 (20%), Positives = 103/293 (35%), Gaps = 40/293 (13%) Query: 42 YTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPV 101 + VPV S Y HSH S G Y S +R+W+ T + Sbjct: 55 FGVPVRS------YKGHSHIVQDVVVSADGNYAVSASWDKTLRLWNLA--TGNSEARFVG 106 Query: 102 FSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDT-GTSNGNLTGQARAMNSVDFKP--- 157 +G V ++ D+ S +I + + + +++T G L G + V P Sbjct: 107 HTGDVLSVAIDANSSKIISASRDKT----IRVWNTVGDCAYVLLGHTDWVTKVRVAPKNL 162 Query: 158 ------SRPFRIISGSDDNTVAIF--EGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTG 209 +S D V + ++ ++ F H +++ V+ +PDGSL AS G Sbjct: 163 EDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAG 222 Query: 210 GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVA 269 DG I ++N + F+ VF L +SP + +A+A IKI+++ Sbjct: 223 KDGQIYVWNLKHKSAFMNFDA--------KDEVFALAFSPSRFWLTAATASG-IKIYDLE 273 Query: 270 TLKVEKTIPV-------GTRIEDQQLGIIWTKQALVSISANGFINFVNPELGS 315 + + L Q L + + I + Sbjct: 274 NEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTAN 326 Score = 153 bits (387), Expect = 2e-37, Method: Composition-based stats. Identities = 68/360 (18%), Positives = 124/360 (34%), Gaps = 58/360 (16%) Query: 138 TSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFK-----FKSTFGEHTKF 192 G L G + S+ ++P ++SGS D T+ + + ++ H+ Sbjct: 9 VLRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHI 68 Query: 193 VHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGT 252 V V + DG+ S D T+ L+N G F V H+G V + + + Sbjct: 69 VQDVVVSADGNYAVSASWDKTLRLWNLATGNSEARF-------VGHTGDVLSVAIDANSS 121 Query: 253 KIASASADKTIKIWNVATLKVEKTIPVGT---------RIEDQQLGIIWTKQALVSISAN 303 KI SAS DKTI++WN + T + + + VS + Sbjct: 122 KIISASRDKTIRVWNTV-GDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMD 180 Query: 304 GFINFVNPELGS--IDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRV 361 + + S I+ GHN I + S DG SA +G I W++ + Sbjct: 181 KIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMN 240 Query: 362 FPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSA 421 F + + + T + +K+ + + ++L + G + Sbjct: 241 F--DAKDEVFALAFSPSRFWLTAATASGIKIYDLEN------EVLIDELKPEFAGYTKAQ 292 Query: 422 DGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGAS 481 D + +A S D Q + G D+ + V+++ A+ Sbjct: 293 DPH--------------------------AVSLAWSADGQTLFAGYTDNVIRVWQVMTAN 326 Score = 138 bits (346), Expect = 8e-33, Method: Composition-based stats. Identities = 61/339 (17%), Positives = 116/339 (34%), Gaps = 42/339 (12%) Query: 237 AHSGSVFGLTWSPDGT-KIASASADKTIKIWNVATLKVEKTIPV----GTRIEDQQLGII 291 H+G V L+ S + S S DKT+ W + + + +PV G Q + + Sbjct: 16 GHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVVVS 75 Query: 292 WTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 VS S + + N G+ + GH + +++ A+ + SA + I W Sbjct: 76 ADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISASRDKTIRVW 135 Query: 352 DISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLS 411 + + G V H +T ++ K + + Sbjct: 136 N-TVGDCAYVLLG-HTDWVTKVRVAPK----------------------NLEDGEVDDGR 171 Query: 412 SQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSK 471 + + G + + + + + + V S D A G+D + Sbjct: 172 -----ITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQ 226 Query: 472 VHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTN- 530 ++V+ L S E+ ++AFS + +L A S + Y + N + Sbjct: 227 IYVWNLK--HKSAFMNFDAKDEVFALAFSPSRFWLTAATASG-IKIYDLENEVLIDELKP 283 Query: 531 SWTFHTAK----VACVSWSPDNVRLATGSLDNSVIVWNM 565 + +T ++WS D L G DN + VW + Sbjct: 284 EFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQV 322 Score = 90.7 bits (223), Expect = 2e-18, Method: Composition-based stats. Identities = 50/274 (18%), Positives = 99/274 (36%), Gaps = 34/274 (12%) Query: 359 NRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVV--------PAGGSGVDSSKAVANKL 410 R + H +T + T++ VS ++ G V S K ++ + Sbjct: 10 LRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIV 69 Query: 411 SSQPLGLAVSADGDIAVAACY-KHIAIYS----HGKLTEVPISYNSSCVALSNDKQFVAV 465 + VSADG+ AV+A + K + +++ + + V + + VA+ + + Sbjct: 70 QD----VVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIIS 125 Query: 466 GGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSN---------NGAF-LVATDQSRKV 515 +D + V+ G + H +T V + +G V+ + V Sbjct: 126 ASRDKTIRVWNTVGDCAYVLL--GHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIV 183 Query: 516 IPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIII 575 +S+ N + H + V SPD A+ D + VWN+ H Sbjct: 184 RSWSL-NEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLK----HKSAF 238 Query: 576 KGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 A V ++ + ++A S IK +++ Sbjct: 239 MNFDAKDEVFALAFSPSRFWLTAATASGIKIYDL 272 Score = 87.2 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 52/315 (16%), Positives = 114/315 (36%), Gaps = 29/315 (9%) Query: 319 VRYGHNKAITALSSSA-DGKTLFSADAEGHINSWDISTGISN----RVFPDVHATMITGI 373 GHN +T+LS+SA L S + + SW ++ H+ ++ + Sbjct: 13 TLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDV 72 Query: 374 KTTSKGDL-FTVSWDDHLKVVP-------AGGSGVDSSKAVANKLSSQPLGLAVSADGDI 425 ++ G+ + SWD L++ A G ++ ++ S D I Sbjct: 73 VVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISASRDKTI 132 Query: 426 AVAACYKHIAIYSHG---KLTEVPISYNSSCVALSNDKQF-VAVGGQDSKVHVYKLSGAS 481 V A G +T+V ++ + +D + G D V + L+ S Sbjct: 133 RVWNTVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLNEDS 192 Query: 482 -VSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVA 540 E I H I V S +G+ + + ++ +++ + + ++ +V Sbjct: 193 YRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDA----KDEVF 248 Query: 541 CVSWSPDNVRLATGSLDNSVIVWN------MNKPSDHPIIIKGAHAMSSVNSVIWLNETT 594 +++SP L + + +++ +++ A +V+ + T Sbjct: 249 ALAFSPSRFWLTAATASG-IKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQT 307 Query: 595 IVSAGQDSNIKFWNV 609 + + D+ I+ W V Sbjct: 308 LFAGYTDNVIRVWQV 322 Score = 50.3 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 17/154 (11%), Positives = 43/154 (27%), Gaps = 15/154 (9%) Query: 36 CNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHIL 95 +++ S + H++ V + SP G AS G + +W+ + + Sbjct: 180 DKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFM 239 Query: 96 KTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMN---- 151 V +++ + A ++ + L + Sbjct: 240 N---FDAKDEVFALAFSPSRFWLTAATAS---GIKIYDLENEVLIDELKPEFAGYTKAQD 293 Query: 152 ----SVDFKPSRPFRIISGSDDNTVAIFEGPPFK 181 S+ + G DN + +++ Sbjct: 294 PHAVSLAWSADGQTLFA-GYTDNVIRVWQVMTAN 326 >4BTS-AR nrPDB Length = 343 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 72/340 (21%), Positives = 122/340 (35%), Gaps = 51/340 (15%) Query: 53 EIYTEHSHQTTVA------KTSPSGYYCASGDVHGNVRIWDTTQTTHIL-----KTTIPV 101 I HS T K + SG V IW + + Sbjct: 15 GILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTG 74 Query: 102 FSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPF 161 + V D++ E+ + + ++ TGT+ G + SV F P Sbjct: 75 HNHFVSDLALSQENCFAISSSWDK--TLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNR- 131 Query: 162 RIISGSDDNTVAIFE-GPPFKF-KSTFGEHTKFVHSVRYNPD----------GSLFASTG 209 +I+S + + ++ KF + H+ +V VRY+P FAS G Sbjct: 132 QILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVG 191 Query: 210 GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVA 269 DG + ++N + AH +V L+ SP+G IA+ DK + IW++ Sbjct: 192 WDGRLKVWNTNFQIR--------YTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDIL 243 Query: 270 TLK-VEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQV--------- 319 L ++ G+ I Q+ Q V++ + + N S V Sbjct: 244 NLTYPQREFDAGSTI--NQIAFNPKLQW-VAVGTDQGVKIFNLMTQSKAPVCTIEAEPIT 300 Query: 320 ----RYGHNKAITALSSSADGKTLFSADAEGHINSWDIST 355 + G N T+L+ +A GK LF+ +G I ++ T Sbjct: 301 KAEGQKGKNPQCTSLAWNALGKKLFAGFTDGVIRTFSFET 340 Score = 126 bits (315), Expect = 3e-29, Method: Composition-based stats. Identities = 53/327 (16%), Positives = 111/327 (33%), Gaps = 33/327 (10%) Query: 94 ILKTTIPVFSGPVKDI--SWDS----ESKRIAAVGEGRE-RFGHVFLFDT----GTSNGN 142 + + + S V I + +S + + + ++ + G + Sbjct: 12 VKRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKA 71 Query: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDG 202 LTG ++ + F I S S D T+ +++ F H V+SV ++PD Sbjct: 72 LTGHNHFVSDLALSQENCFAI-SSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDN 130 Query: 203 SLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS----------PDGT 252 S G + I L+N G + S + HS V + +S P Sbjct: 131 RQILSAGAEREIKLWNI-----LGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAP 185 Query: 253 KIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPE 312 AS D +K+WN ++ T + L I + + + + + + Sbjct: 186 YFASVGWDGRLKVWNT-NFQIRYTFKAHESNVNH-LSISPNGKYIATGGKDKKLLIWDIL 243 Query: 313 LGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITG 372 + Q + I ++ + + + + + +++ T S + A IT Sbjct: 244 NLTYPQREFDAGSTINQIAFNPKLQWVAVG-TDQGVKIFNLMT-QSKAPVCTIEAEPITK 301 Query: 373 IK--TTSKGDLFTVSWDDHLKVVPAGG 397 + +++W+ K + AG Sbjct: 302 AEGQKGKNPQCTSLAWNALGKKLFAGF 328 Score = 126 bits (315), Expect = 4e-29, Method: Composition-based stats. Identities = 63/370 (17%), Positives = 115/370 (31%), Gaps = 75/370 (20%) Query: 185 TFGEHTKFVHSV------RYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAH 238 H+ +V S+ + N D + S D T++++ + + G F H Sbjct: 16 ILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGH 75 Query: 239 SGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALV 298 + V L S + S+S DKT+++W++ T K VG + E + + ++ Sbjct: 76 NHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRF-VGHQSEVYSVAFSPDNRQIL 134 Query: 299 SISANGFINFVNPELGSID---QVRYGHNKAITALSSSADGK----------TLFSADAE 345 S A I N LG + H+ ++ + S K S + Sbjct: 135 SAGAEREIKLWNI-LGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWD 193 Query: 346 GHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKA 405 G + W+ T R H + + + + G D ++ + Sbjct: 194 GRLKVWN--TNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDILNLTYPQ-- 249 Query: 406 VANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAV 465 E + +A + Q+VAV Sbjct: 250 -------------------------------------REFDAGSTINQIAFNPKLQWVAV 272 Query: 466 GGQDSKVHVYKLSGASVSEVKTIVHPAEI------------TSVAFSNNGAFLVATDQSR 513 G D V ++ L S + V TI TS+A++ G L A Sbjct: 273 GT-DQGVKIFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFAGFTDG 331 Query: 514 KVIPYSVANN 523 + +S + Sbjct: 332 VIRTFSFETS 341 Score = 112 bits (280), Expect = 4e-25, Method: Composition-based stats. Identities = 42/308 (13%), Positives = 101/308 (32%), Gaps = 57/308 (18%) Query: 319 VRYGHNKAITALSS------SADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITG 372 + GH+ +T++ + + D L S + + W + N F H + Sbjct: 16 ILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKAL--- 72 Query: 373 IKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYK 432 + + F + A S D + + + + V ++ Sbjct: 73 ----TGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVY------ 122 Query: 433 HIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASV-SEVKTIVHP 491 VA S D + + G + ++ ++ + G S + H Sbjct: 123 --------------------SVAFSPDNRQILSAGAEREIKLWNILGECKFSSAEKENHS 162 Query: 492 AEITSVAFSNN----------GAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVAC 541 ++ V +S + + ++ ++ ++ H + V Sbjct: 163 DWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNTNFQIR----YTFKAHESNVNH 218 Query: 542 VSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQD 601 +S SP+ +ATG D +++W++ + S++N + + + V+ G D Sbjct: 219 LSISPNGKYIATGGKDKKLLIWDILNLTYPQREFDAG---STINQIAFNPKLQWVAVGTD 275 Query: 602 SNIKFWNV 609 +K +N+ Sbjct: 276 QGVKIFNL 283 Score = 104 bits (258), Expect = 2e-22, Method: Composition-based stats. Identities = 35/256 (13%), Positives = 82/256 (32%), Gaps = 25/256 (9%) Query: 34 QYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTH 93 + ++ + G+ + + H + SP S +++W+ Sbjct: 95 SWDKTLRLWDLRTGTTY--KRFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGECK 152 Query: 94 ILKTTIPVFSGPVKDISWDSESK----------RIAAVGEGRERFGHVFLFDT-GTSNGN 142 S V + + K A+VG G + +++T Sbjct: 153 FSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWD----GRLKVWNTNFQIRYT 208 Query: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDG 202 +N + P+ + I +G D + I++ + + ++ + +NP Sbjct: 209 FKAHESNVNHLSISPNGKY-IATGGKDKKLLIWDILNLTYPQREFDAGSTINQIAFNPKL 267 Query: 203 SLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV------AHSGSVFGLTWSPDGTKIAS 256 A G D + ++N + +K V ++ + L W+ G K+ + Sbjct: 268 QWVA-VGTDQGVKIFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFA 326 Query: 257 ASADKTIKIWNVATLK 272 D I+ ++ T Sbjct: 327 GFTDGVIRTFSFETSA 342 Score = 102 bits (254), Expect = 5e-22, Method: Composition-based stats. Identities = 37/199 (18%), Positives = 69/199 (34%), Gaps = 23/199 (11%) Query: 433 HIAIYSHGKLTEVPISYNSSCVALS----NDKQFVAVGGQDSKVHVYKLSGASVSEVKTI 488 I + G L S S D + G +D V ++KL + I Sbjct: 8 DIQVVKRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGI 67 Query: 489 VHPA------EITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACV 542 H A ++ +A S F +++ + + + + + H ++V V Sbjct: 68 PHKALTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTG---TTYKRFVGHQSEVYSV 124 Query: 543 SWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHA--MSSVNSVIWLNE-------- 592 ++SPDN ++ + + + +WN+ K H+ +S V + Sbjct: 125 AFSPDNRQILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFA 184 Query: 593 TTIVSAGQDSNIKFWNVPF 611 S G D +K WN F Sbjct: 185 PYFASVGWDGRLKVWNTNF 203 Score = 53.0 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 24/165 (14%), Positives = 50/165 (30%), Gaps = 19/165 (11%) Query: 28 PAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWD 87 P V + + H SP+G Y A+G + IWD Sbjct: 182 PFAPYFASVGWDGRLKVWNTNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWD 241 Query: 88 TTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLT--- 144 T+ + + I+++ + + +A G ++ +F T + T Sbjct: 242 ILNLTYPQREFDAG--STINQIAFNPKLQWVAV---GTDQGVKIFNLMTQSKAPVCTIEA 296 Query: 145 ----------GQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPP 179 G+ S+ + + ++ +G D + F Sbjct: 297 EPITKAEGQKGKNPQCTSLAWN-ALGKKLFAGFTDGVIRTFSFET 340 >4BH6-A nrPDB Length = 308 Score = 156 bits (393), Expect = 4e-38, Method: Composition-based stats. Identities = 61/347 (17%), Positives = 116/347 (33%), Gaps = 88/347 (25%) Query: 15 RTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYC 74 A G ++ L + GD + C+ + YT +G + Sbjct: 38 AVALGKSIFLTDNNTGDVVHLCDTENEYT--------------------SLSWIGAGSHL 77 Query: 75 ASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLF 134 A G +G V ++ Sbjct: 78 AVGQANGLV----------------------------------------------EIYDV 91 Query: 135 DTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP-PFKFKSTFGEHTKFV 193 L+G + + + + SGS D+ + + P F T HT+ V Sbjct: 92 MKRKCIRTLSGHIDRVACLSWN---NHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEV 148 Query: 194 HSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTK 253 +++N + AS G D + +Y G + F++ H +V + WSP Sbjct: 149 CGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDE-------HKAAVKAMAWSPHKRG 201 Query: 254 IAS---ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFIN--- 307 + + +AD+ +KIWNV T I G++I ++W+K ++++G+ Sbjct: 202 VLATGGGTADRRLKIWNVNTSIKMSDIDSGSQI----CNMVWSKNTNELVTSHGYSKYNL 257 Query: 308 -FVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 + + GH+ + L+ S DG T+ S + + W + Sbjct: 258 TLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 304 Score = 113 bits (283), Expect = 2e-25, Method: Composition-based stats. Identities = 53/325 (16%), Positives = 119/325 (36%), Gaps = 54/325 (16%) Query: 290 IIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHIN 349 I W+ +++++ I + G + + N+ T+LS G L A G + Sbjct: 29 IDWSSTDVLAVALGKSIFLTDNNTGDVVHLCDTENEY-TSLSWIGAGSHLAVGQANGLVE 87 Query: 350 SWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANK 409 +D+ R + +SW++H+ + + ++ Sbjct: 88 IYDVMKRKCIRTLSGHIDR------------VACLSWNNHVLTSGS------RDHRILHR 129 Query: 410 LSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQD 469 P + + + + +A GG D Sbjct: 130 DVRMPDPFFETIESHTQ-----------------------EVCGLKWNVADNKLASGGND 166 Query: 470 SKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVA---TDQSRKVIPYSVANNFEL 526 + VHVY+ + S H A + ++A+S + ++A R++ ++V + ++ Sbjct: 167 NVVHVYEGTSKSPILTFDE-HKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKM 225 Query: 527 AHTNSWTFHTAKVACVSWSPDNVRLAT--GSLDNSVIVWNMNKPSDHPIIIKGAHAMSSV 584 + +S +++ + WS + L T G ++ +W+ N S PI I H+ + Sbjct: 226 SDIDS----GSQICNMVWSKNTNELVTSHGYSKYNLTLWDCN--SMDPIAILKGHSFRVL 279 Query: 585 NSVIWLNETTIVSAGQDSNIKFWNV 609 + + + TT+VS D +++W + Sbjct: 280 HLTLSNDGTTVVSGAGDETLRYWKL 304 Score = 82.2 bits (201), Expect = 5e-16, Method: Composition-based stats. Identities = 31/171 (18%), Positives = 65/171 (38%), Gaps = 5/171 (2%) Query: 53 EIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWD 112 E H+ + K + + ASG V +++ T + IL T VK ++W Sbjct: 139 ETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPIL--TFDEHKAAVKAMAWS 196 Query: 113 SESKRIAAVGEGR-ERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDN- 170 + + A G G +R ++ +T ++ ++ N V + + + S Sbjct: 197 PHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMV-WSKNTNELVTSHGYSKY 255 Query: 171 TVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVD 221 + +++ + H+ V + + DG+ S GD T+ + D Sbjct: 256 NLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFD 306 Score = 68.0 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 41/304 (13%), Positives = 96/304 (31%), Gaps = 49/304 (16%) Query: 228 FEDDSLKNVAH----SGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRI 283 D++ +V H L+W G+ +A A+ ++I++V K +T+ Sbjct: 47 LTDNNTGDVVHLCDTENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGH--- 103 Query: 284 EDQQLGIIWTKQALVSISANGFINFVNPELGSID-QVRYGHNKAITALSSSADGKTLFSA 342 D+ + W L S S + I + + + H + + L + L S Sbjct: 104 IDRVACLSWNNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASG 163 Query: 343 DAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDS 402 + ++ ++ T S + D H + + +W H + V A G G Sbjct: 164 GNDNVVHVYE-GTSKSPILTFDEHKAAVKAM-----------AWSPHKRGVLATGGGTAD 211 Query: 403 SKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQF 462 K + + K++++ + S + Sbjct: 212 --------------------------RRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNE 245 Query: 463 VAV--GGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSV 520 + G + ++ + + H + + SN+G +V+ + + + Sbjct: 246 LVTSHGYSKYNLTLWDCNSMDPIAILK-GHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 304 Query: 521 ANNF 524 + Sbjct: 305 FDKP 308 >5L9T-R nrPDB Length = 493 Score = 155 bits (390), Expect = 8e-38, Method: Composition-based stats. Identities = 50/280 (17%), Positives = 105/280 (37%), Gaps = 25/280 (8%) Query: 83 VRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGN 142 V +W + + V V + W +A + F ++ G Sbjct: 209 VYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAV--GTHKGFVQIWDAAAGKKLSM 266 Query: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKF--KSTFGEHTKFVHSVRYNP 200 L G + ++ + ++ SGS D + + + H + V ++++ Sbjct: 267 LEGHTARVGALAWN---AEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWST 323 Query: 201 DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIAS---A 257 D L AS G D ++++N + + + H +V + WSP + + Sbjct: 324 DHQLLASGGNDNKLLVWNHSSLSPVQQYTE-------HLAAVKAIAWSPHQHGLLASGGG 376 Query: 258 SADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGF----INFVNPEL 313 +AD+ I+ WN T + + I G+ Q + W+K A +S +G+ I Sbjct: 377 TADRCIRFWNTLTGQPLQCIDTGS----QVCNLAWSKHANELVSTHGYSQNQILVWKYPS 432 Query: 314 GSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 + GH+ + L+ S DG+ + + + + W++ Sbjct: 433 LTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472 Score = 151 bits (382), Expect = 6e-37, Method: Composition-based stats. Identities = 54/309 (17%), Positives = 107/309 (34%), Gaps = 21/309 (6%) Query: 14 PRTARGTAVVLGNTPAGDKIQYCNGTSV--YTVPVGSLTDTEIYTEHSHQTTVAKTSPSG 71 P + L + + + + GT V ++ +T + T S G Sbjct: 182 PELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERG 241 Query: 72 YYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHV 131 A G G V+IWD + + + + V ++W++E ++++ R Sbjct: 242 NLVAVGTHKGFVQIWDAAAGKKL--SMLEGHTARVGALAWNAE--QLSSGSRDRMILQRD 297 Query: 132 FLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTK 191 S L G + + + + + SG +DN + ++ + EH Sbjct: 298 IRTPPLQSERRLQGHRQEVCGLKWSTDHQL-LASGGNDNKLLVWNHSSLSPVQQYTEHLA 356 Query: 192 FVHSVRYNPDG-SLFASTG--GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 V ++ ++P L AS G D I +N + G + S V L WS Sbjct: 357 AVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQ--------VCNLAWS 408 Query: 249 PDGTKIAS--ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFI 306 ++ S + I +W +L + G L + +A+V+ + + + Sbjct: 409 KHANELVSTHGYSQNQILVWKYPSLTQVAKL-TGHSYRVLYLAMSPDGEAIVTGAGDETL 467 Query: 307 NFVNPELGS 315 F N + Sbjct: 468 RFWNVFSKT 476 Score = 118 bits (296), Expect = 6e-27, Method: Composition-based stats. Identities = 38/184 (20%), Positives = 78/184 (42%), Gaps = 12/184 (6%) Query: 430 CYKHIAIYSHGKLTEVPISYNS-SCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTI 488 +L ++ + +S + V S VAVG V ++ + + Sbjct: 210 YLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLE- 268 Query: 489 VHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDN 548 H A + ++A+ N L + + R ++ + L H +V + WS D+ Sbjct: 269 GHTARVGALAW--NAEQLSSGSRDRMILQRDIRT-PPLQSERRLQGHRQEVCGLKWSTDH 325 Query: 549 VRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW-LNETTIVSAG---QDSNI 604 LA+G DN ++VWN + S + + +++V ++ W ++ ++++G D I Sbjct: 326 QLLASGGNDNKLLVWNHSSLSP---VQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCI 382 Query: 605 KFWN 608 +FWN Sbjct: 383 RFWN 386 Score = 115 bits (288), Expect = 5e-26, Method: Composition-based stats. Identities = 51/327 (15%), Positives = 112/327 (34%), Gaps = 54/327 (16%) Query: 290 IIWTKQALVSISANGFINFVNPELGSIDQV--RYGHNKAITALSSSADGKTLFSADAEGH 347 + W+ ++S+ + + + ++ ++T++ S G + +G Sbjct: 193 VDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGF 252 Query: 348 INSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVA 407 + WD + G + H + + + + + D + Sbjct: 253 VQIWDAAAGKKLSMLEG-HTARVGALAWNA--EQLSSGSRDRM----------------- 292 Query: 408 NKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGG 467 + + + S +L + S D Q +A GG Sbjct: 293 ------------------ILQRDIRTPPLQSERRLQ--GHRQEVCGLKWSTDHQLLASGG 332 Query: 468 QDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVA---TDQSRKVIPYSVANNF 524 D+K+ V+ S S + T H A + ++A+S + L+A R + ++ Sbjct: 333 NDNKLLVWNHSSLSPVQQYTE-HLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQ 391 Query: 525 ELAHTNSWTFHTAKVACVSWSPDNVRLAT--GSLDNSVIVWNMNKPSDHPIIIKGAHAMS 582 L ++ ++V ++WS L + G N ++VW PS + H+ Sbjct: 392 PLQCIDT----GSQVCNLAWSKHANELVSTHGYSQNQILVW--KYPSLTQVAKLTGHSYR 445 Query: 583 SVNSVIWLNETTIVSAGQDSNIKFWNV 609 + + + IV+ D ++FWNV Sbjct: 446 VLYLAMSPDGEAIVTGAGDETLRFWNV 472 Score = 93.8 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 34/181 (18%), Positives = 67/181 (37%), Gaps = 9/181 (4%) Query: 49 LTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKD 108 L H + K S ASG + +W+ + + + + T VK Sbjct: 303 LQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYT--EHLAAVKA 360 Query: 109 ISWDS-ESKRIAAVGEGRERFGHVFLFDTGT-SNGNLTGQARAMNSVDFKPSRPFRIIS- 165 I+W + +A+ G +R + TG TG + ++ + ++S Sbjct: 361 IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTG--SQVCNLAWSK-HANELVST 417 Query: 166 -GSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTK 224 G N + +++ P + H+ V + +PDG + GD T+ +N T+ Sbjct: 418 HGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTR 477 Query: 225 T 225 + Sbjct: 478 S 478 Score = 88.0 bits (216), Expect = 1e-17, Method: Composition-based stats. Identities = 50/289 (17%), Positives = 98/289 (33%), Gaps = 18/289 (6%) Query: 205 FASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIK 264 S G + L++ T + + SV + WS G +A + ++ Sbjct: 200 VLSVGLGTCVYLWSACTSQVTRLCDLSVEG-----DSVTSVGWSERGNLVAVGTHKGFVQ 254 Query: 265 IWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSI--DQVRYG 322 IW+ A K + T + + W + L S S + I + + ++ G Sbjct: 255 IWDAAAGKKLSMLEGHTA---RVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQG 311 Query: 323 HNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLF 382 H + + L S D + L S + + W+ S+ + + + H + I + Sbjct: 312 HRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTE-HLAAVKAIAWSPHQHGL 370 Query: 383 TVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAA---CYKHIAIYSH 439 S + + SQ LA S + V+ I ++ + Sbjct: 371 LASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKY 430 Query: 440 GKLTEV----PISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSE 484 LT+V SY +A+S D + + G D + + + + S Sbjct: 431 PSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRST 479 Score = 42.6 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 19/81 (23%), Positives = 32/81 (39%), Gaps = 3/81 (3%) Query: 24 LGNTPAGDKIQYCNGTSVYTVPV---GSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVH 80 L + +++ +G S + V SLT T HS++ SP G +G Sbjct: 405 LAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGD 464 Query: 81 GNVRIWDTTQTTHILKTTIPV 101 +R W+ T K ++ V Sbjct: 465 ETLRFWNVFSKTRSTKESVSV 485 >6GMH-W nrPDB Length = 305 Score = 154 bits (389), Expect = 9e-38, Method: Composition-based stats. Identities = 58/306 (18%), Positives = 112/306 (36%), Gaps = 14/306 (4%) Query: 89 TQTTHILKTTIPVFSGPVKDISW--DSESKRIAAVGEGRERFGHVFLFDTGTSNGN--LT 144 T IL + ++W + + V + V+ + + L Sbjct: 2 TNQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLE 61 Query: 145 GQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSL 204 G + SVD + P S S D + +++ K + ++ ++PD Sbjct: 62 GHQLGVVSVDISHTLPIA-ASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQY 120 Query: 205 FASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIK 264 A+ G + ++ G K + + + +SPDG +AS + D I Sbjct: 121 LATGTHVGKVNIFGVESGKKEYSLDTRGKF-------ILSIAYSPDGKYLASGAIDGIIN 173 Query: 265 IWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHN 324 I+++AT K+ T+ G + + L Q LV+ S +G+I + + ++ GH Sbjct: 174 IFDIATGKLLHTLE-GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHA 232 Query: 325 KAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTV 384 + ++ D S+ ++ + WD+ T F D H + G+K G Sbjct: 233 SWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFD-HQDQVWGVKYNGNGSKIVS 291 Query: 385 SWDDHL 390 DD Sbjct: 292 VGDDQE 297 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 54/302 (17%), Positives = 107/302 (35%), Gaps = 15/302 (4%) Query: 56 TEHSHQTTVAKT----SPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISW 111 H + +G + V++W L+ ++ V +S Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGV--VSV 70 Query: 112 DSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNT 171 D A + ++ + G ++ ++ F P + + +G+ Sbjct: 71 DISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQY-LATGTHVGK 129 Query: 172 VAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDD 231 V IF K + + KF+ S+ Y+PDG AS DG I +++ G E Sbjct: 130 VNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLE-- 187 Query: 232 SLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGII 291 H+ + LT+SPD + +AS D IKI++V + T+ G + Sbjct: 188 -----GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLS-GHASWVLNVAFC 241 Query: 292 WTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 VS S++ + + + + H + + + +G + S + I+ + Sbjct: 242 PDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301 Query: 352 DI 353 D Sbjct: 302 DC 303 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 59/309 (19%), Positives = 114/309 (36%), Gaps = 17/309 (5%) Query: 137 GTSNGNLTGQARAMNSVDF---KPSRPFRIISGSDDNTVAIFEGPPFKF--KSTFGEHTK 191 G A+ SV + K +++GS D+ V +++ + + + H Sbjct: 6 GILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQL 65 Query: 192 FVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG 251 V SV + + AS+ D I L++ +G + + + + L +SPD Sbjct: 66 GVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDA-------WTLAFSPDS 118 Query: 252 TKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNP 311 +A+ + + I+ V + K E ++ + + + L S + +G IN + Sbjct: 119 QYLATGTHVGKVNIFGVESGKKEYSLDTRGKF-ILSIAYSPDGKYLASGAIDGIINIFDI 177 Query: 312 ELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMIT 371 G + GH I +L+ S D + L +A +G+I +D+ HA+ + Sbjct: 178 ATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSG-HASWVL 236 Query: 372 GIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAV-AAC 430 + F S D V G+ + Q G+ + +G V Sbjct: 237 NVAFCPDDTHFVSSSSDKSVKVWDVGT--RTCVHTFFDHQDQVWGVKYNGNGSKIVSVGD 294 Query: 431 YKHIAIYSH 439 + I IY Sbjct: 295 DQEIHIYDC 303 Score = 125 bits (314), Expect = 5e-29, Method: Composition-based stats. Identities = 57/282 (20%), Positives = 110/282 (39%), Gaps = 21/282 (7%) Query: 34 QYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTH 93 + V+ L H S + AS + ++R+WD Sbjct: 39 SLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQ 98 Query: 94 ILKTTIPVFSGPVKD--ISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMN 151 I +GPV +++ +S+ +A ++F ++G +L + + + Sbjct: 99 IKSID----AGPVDAWTLAFSPDSQYLAT--GTHVGKVNIFGVESGKKEYSLDTRGKFIL 152 Query: 152 SVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGD 211 S+ + P + + SG+ D + IF+ K T H + S+ ++PD L + D Sbjct: 153 SIAYSPDGKY-LASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDD 211 Query: 212 GTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATL 271 G I +Y+ G H+ V + + PD T S+S+DK++K+W+V T Sbjct: 212 GYIKIYDVQHANLAGTLS-------GHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTR 264 Query: 272 KVEKTIPVGTRIEDQQLGIIWTKQA--LVSISANGFINFVNP 311 T +DQ G+ + +VS+ + I+ + Sbjct: 265 TCVHTFFDH---QDQVWGVKYNGNGSKIVSVGDDQEIHIYDC 303 Score = 108 bits (268), Expect = 9e-24, Method: Composition-based stats. Identities = 47/347 (13%), Positives = 111/347 (31%), Gaps = 49/347 (14%) Query: 225 TGVFEDDSLKNVAHSGSVFGLTW----SPDGTKIASASADKTIKIWNVATLKV-EKTIPV 279 T + + AH +++ + W + + + S D +K+W ++ + Sbjct: 2 TNQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLE 61 Query: 280 GTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTL 339 G ++ + I T S S + I + E G + L+ S D + L Sbjct: 62 GHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYL 121 Query: 340 FSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSG 399 + G +N + + +G D I I + G Sbjct: 122 ATGTHVGKVNIFGVESGK-KEYSLDTRGKFILSIAYSPDGKYLASG-------------- 166 Query: 400 VDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSND 459 + + N L + +G + + S D Sbjct: 167 --AIDGIINIFDIATGKLLHTLEGH-----------------------AMPIRSLTFSPD 201 Query: 460 KQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYS 519 Q + D + +Y + A+++ + H + + +VAF + V++ + V + Sbjct: 202 SQLLVTASDDGYIKIYDVQHANLAGTLS-GHASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260 Query: 520 VANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMN 566 V + ++ H +V V ++ + ++ + D + +++ Sbjct: 261 VGTRTCVH---TFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDCP 304 Score = 108 bits (268), Expect = 1e-23, Method: Composition-based stats. Identities = 51/309 (16%), Positives = 106/309 (34%), Gaps = 18/309 (5%) Query: 312 ELGSIDQVRYGHNKAITALSSSAD----GKTLFSADAEGHINSWDISTGIS-NRVFPDVH 366 + G + + H+ AI +++ + +T+ + + + W + + H Sbjct: 4 QYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGH 63 Query: 367 ATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIA 426 + + + + S D + +G A + + LA S D Sbjct: 64 QLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDA--WTLAFSPDSQYL 121 Query: 427 VAAC-YKHIAIYSHGKLTEVPI----SYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGAS 481 + I+ + +A S D +++A G D ++++ ++ Sbjct: 122 ATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGK 181 Query: 482 VSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVAC 541 + H I S+ FS + LV + Y V + + + H + V Sbjct: 182 LLHTLE-GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHA---NLAGTLSGHASWVLN 237 Query: 542 VSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQD 601 V++ PD+ + S D SV VW++ + + V N + IVS G D Sbjct: 238 VAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNG--NGSKIVSVGDD 295 Query: 602 SNIKFWNVP 610 I ++ P Sbjct: 296 QEIHIYDCP 304 Score = 70.7 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 21/156 (13%), Positives = 51/156 (32%), Gaps = 6/156 (3%) Query: 24 LGNTPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGN 82 + +P G + + + + + H+ SP + G Sbjct: 154 IAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGY 213 Query: 83 VRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGN 142 ++I+D L T+ + V ++++ + + ++ V+ T T Sbjct: 214 IKIYDVQH--ANLAGTLSGHASWVLNVAFCPDDTHFVS--SSSDKSVKVWDVGTRTCVHT 269 Query: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP 178 + V + +I+S DD + I++ P Sbjct: 270 FFDHQDQVWGVKYN-GNGSKIVSVGDDQEIHIYDCP 304 >5A31-R nrPDB Length = 386 Score = 153 bits (387), Expect = 2e-37, Method: Composition-based stats. Identities = 51/259 (19%), Positives = 99/259 (38%), Gaps = 24/259 (9%) Query: 103 SGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFR 162 +SW +A ++ L+G + + + Sbjct: 131 ENEYTSLSWIGAGSHLAV--GQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN---NHV 185 Query: 163 IISGSDDNTVAIFEGP-PFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVD 221 + SGS D+ + + P F T HT+ V +++N + AS G D + +Y G Sbjct: 186 LTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTS 245 Query: 222 GTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIAS---ASADKTIKIWNVATLKVEKTIP 278 + F++ H +V + WSP + + +AD+ +KIWNV T I Sbjct: 246 KSPILTFDE-------HKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDID 298 Query: 279 VGTRIEDQQLGIIWTKQALVSISANGFIN----FVNPELGSIDQVRYGHNKAITALSSSA 334 G++I ++W+K ++++G+ + + GH+ + L+ S Sbjct: 299 SGSQI----CNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSN 354 Query: 335 DGKTLFSADAEGHINSWDI 353 DG T+ S + + W + Sbjct: 355 DGTTVVSGAGDETLRYWKL 373 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 49/311 (15%), Positives = 109/311 (35%), Gaps = 40/311 (12%) Query: 15 RTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYC 74 A G ++ L + GD + C+ + YT +G + Sbjct: 107 AVALGKSIFLTDNNTGDVVHLCDTENEYT--------------------SLSWIGAGSHL 146 Query: 75 ASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLF 134 A G +G V I+D + + I SG + ++ S + + G R H + Sbjct: 147 AVGQANGLVEIYDVMK-----RKCIRTLSGHIDRVACLSWNNHVLTSGSRDHRILHRDVR 201 Query: 135 DTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVH 194 + + + + + + ++ SG +DN V ++EG TF EH V Sbjct: 202 MPDPFFETIESHTQEVCGLKWNVADN-KLASGGNDNVVHVYEGTSKSPILTFDEHKAAVK 260 Query: 195 SVRYNPDGS-LFASTG--GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG 251 ++ ++P + A+ G D + ++N K + S + + WS + Sbjct: 261 AMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQ--------ICNMVWSKNT 312 Query: 252 TKIAS--ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFV 309 ++ + + + +W+ ++ + G L + +VS + + + + Sbjct: 313 NELVTSHGYSKYNLTLWDCNSMDPIAILK-GHSFRVLHLTLSNDGTTVVSGAGDETLRYW 371 Query: 310 NPELGSIDQVR 320 S+ + Sbjct: 372 KLFDVSVLNLF 382 Score = 116 bits (289), Expect = 4e-26, Method: Composition-based stats. Identities = 53/325 (16%), Positives = 119/325 (36%), Gaps = 54/325 (16%) Query: 290 IIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHIN 349 I W+ +++++ I + G + + N+ T+LS G L A G + Sbjct: 98 IDWSSTDVLAVALGKSIFLTDNNTGDVVHLCDTENEY-TSLSWIGAGSHLAVGQANGLVE 156 Query: 350 SWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANK 409 +D+ R + +SW++H+ + + ++ Sbjct: 157 IYDVMKRKCIRTLSGHIDR------------VACLSWNNHVLTSGS------RDHRILHR 198 Query: 410 LSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQD 469 P + + + + +A GG D Sbjct: 199 DVRMPDPFFETIESHTQ-----------------------EVCGLKWNVADNKLASGGND 235 Query: 470 SKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVA---TDQSRKVIPYSVANNFEL 526 + VHVY+ + S H A + ++A+S + ++A R++ ++V + ++ Sbjct: 236 NVVHVYEGTSKSPILTFDE-HKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKM 294 Query: 527 AHTNSWTFHTAKVACVSWSPDNVRLAT--GSLDNSVIVWNMNKPSDHPIIIKGAHAMSSV 584 + +S +++ + WS + L T G ++ +W+ N S PI I H+ + Sbjct: 295 SDIDS----GSQICNMVWSKNTNELVTSHGYSKYNLTLWDCN--SMDPIAILKGHSFRVL 348 Query: 585 NSVIWLNETTIVSAGQDSNIKFWNV 609 + + + TT+VS D +++W + Sbjct: 349 HLTLSNDGTTVVSGAGDETLRYWKL 373 Score = 69.5 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 48/279 (17%), Positives = 97/279 (34%), Gaps = 24/279 (8%) Query: 228 FEDDSLKNVAH----SGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRI 283 D++ +V H L+W G+ +A A+ ++I++V K +T+ Sbjct: 116 LTDNNTGDVVHLCDTENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGH--- 172 Query: 284 EDQQLGIIWTKQALVSISANGFINFVNPELGSID-QVRYGHNKAITALSSSADGKTLFSA 342 D+ + W L S S + I + + + H + + L + L S Sbjct: 173 IDRVACLSWNNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASG 232 Query: 343 DAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSW----DDHLKVVPAGGS 398 + ++ ++ T S + D H + + + + D LK+ Sbjct: 233 GNDNVVHVYE-GTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVN-- 289 Query: 399 GVDSSKAVANKLSSQPLGLAVSADGDIAVAA---CYKHIAIYSHGKLTEV----PISYNS 451 S K SQ + S + + V + ++ ++ + + S+ Sbjct: 290 --TSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRV 347 Query: 452 SCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVH 490 + LSND V G D + +KL SV + T + Sbjct: 348 LHLTLSNDGTTVVSGAGDETLRYWKLFDVSVLNLFTRIR 386 Score = 58.3 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 22/168 (13%), Positives = 56/168 (33%), Gaps = 8/168 (4%) Query: 24 LGNTPAGDKIQYCNGTSVYTVPVGSLTDTEI-YTEHSHQTTVAKTSPSGYYCAS---GDV 79 L A +K+ +V V G+ + + EH SP + G Sbjct: 220 LKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTA 279 Query: 80 HGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTS 139 ++IW+ + +K + + ++ W + + + ++ ++ Sbjct: 280 DRRLKIWNVNTS---IKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDP 336 Query: 140 NGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFG 187 L G + + + + ++SG+ D T+ ++ + F Sbjct: 337 IAILKGHSFRVLHLTLS-NDGTTVVSGAGDETLRYWKLFDVSVLNLFT 383 Score = 48.3 bits (113), Expect = 9e-06, Method: Composition-based stats. Identities = 36/213 (16%), Positives = 77/213 (36%), Gaps = 11/213 (5%) Query: 397 GSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVAL 456 G+G++ + S P L+ ++ + + IA + L ++ + + Sbjct: 40 GAGIEKVQKGLFTYSLSPYSLSPVSNKSQKLLRS-RQIAKVPYRVLDAPSLADDFYYSLI 98 Query: 457 SNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVI 516 V + + + V + E TS+++ G+ L + V Sbjct: 99 DWSSTDVLAVALGKSIFLTDNNTGDVVHLCDT--ENEYTSLSWIGAGSHLAVGQANGLVE 156 Query: 517 PYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIK 576 Y V + + + H +VAC+SW +N L +GS D+ ++ ++ P I Sbjct: 157 IYDV---MKRKCIRTLSGHIDRVACLSW--NNHVLTSGSRDHRILHRDVRMPDPFFETI- 210 Query: 577 GAHAMSSVNSVIWL-NETTIVSAGQDSNIKFWN 608 V + W + + S G D+ + + Sbjct: 211 -ESHTQEVCGLKWNVADNKLASGGNDNVVHVYE 242 >4AEZ-A nrPDB Length = 401 Score = 151 bits (382), Expect = 6e-37, Method: Composition-based stats. Identities = 60/269 (22%), Positives = 105/269 (39%), Gaps = 26/269 (9%) Query: 56 TEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSES 115 T+ S K S G + + G +G V I+D T + T+ V +SW+ Sbjct: 131 TDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTKL--RTMAGHQARVGCLSWN--- 185 Query: 116 KRIAAVGEGRERFGHVFLFDTGTSN---GNLTGQARAMNSVDFKPSRPFRIISGSDDNTV 172 + + + G R G + D +N G L G + + + ++ S ++ SG +DN V Sbjct: 186 RHVLSSGS---RSGAIHHHDVRIANHQIGTLQGHSSEVCGLAWR-SDGLQLASGGNDNVV 241 Query: 173 AIFEGPPFKFKSTFGEHTKFVHSVRYNPDGS-LFASTGG--DGTIVLYNGVDGTKTGVFE 229 I++ K T H V +V + P S L A+ GG D I +N G + + Sbjct: 242 QIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVD 301 Query: 230 DDSLKNVAHSGSVFGLTWSPDGTKIAS--ASADKTIKIWNVATLKVEKTIPV-GTRIEDQ 286 S V L WSP +I S D + IW+ ++ + K + + Sbjct: 302 AGSQ--------VTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVL 353 Query: 287 QLGIIWTKQALVSISANGFINFVNPELGS 315 + + L + +++ + F G Sbjct: 354 YSALSPDGRILSTAASDENLKFWRVYDGD 382 Score = 104 bits (259), Expect = 1e-22, Method: Composition-based stats. Identities = 48/278 (17%), Positives = 112/278 (40%), Gaps = 12/278 (4%) Query: 339 LFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPA--G 396 + + E ++ W+ +G + + +T + +K + G +V + L + Sbjct: 106 VVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVES 165 Query: 397 GSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVAL 456 + + + ++ V + G + A + + I +H T S +A Sbjct: 166 QTKLRTMAGHQARVGCLSWNRHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVCGLAW 225 Query: 457 SNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVA---TDQSR 513 +D +A GG D+ V ++ S+ + H A + +VA+ + L+A + Sbjct: 226 RSDGLQLASGGNDNVVQIWDARS-SIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDK 284 Query: 514 KVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLAT--GSLDNSVIVWNMNKPSDH 571 ++ ++ A + ++ ++V + WSP + + + G DN++ +W+ + Sbjct: 285 QIHFWNAATGARVNTVDA----GSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLT 340 Query: 572 PIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 + AH + S + + + +A D N+KFW V Sbjct: 341 KQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRV 378 Score = 93.0 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 34/178 (19%), Positives = 61/178 (34%), Gaps = 7/178 (3%) Query: 53 EIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWD 112 HS + G ASG V+IWD + T + VK ++W Sbjct: 211 GTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKT--NHNAAVKAVAWC 268 Query: 113 SESKRIAAVGEGR-ERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIIS-GSDDN 170 + A G G ++ H + TG + ++ + S+ + P + + G DN Sbjct: 269 PWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQ-VTSLIWSPHSKEIMSTHGFPDN 327 Query: 171 TVAIFEGPPFKFKST--FGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTG 226 ++I+ H V +PDG + ++ D + + DG Sbjct: 328 NLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHVK 385 Score = 93.0 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 40/293 (13%), Positives = 92/293 (31%), Gaps = 12/293 (4%) Query: 245 LTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANG 304 L WS + + + ++ + +WN + V + L NG Sbjct: 99 LDWS--NLNVVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNG 156 Query: 305 FINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPD 364 ++ + E + + GH + LS + L S G I+ D+ Sbjct: 157 LVDIYDVESQTKLRTMAGHQARVGCLSWNR--HVLSSGSRSGAIHHHDVRIANHQIGTLQ 214 Query: 365 VHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVAN--KLSSQPLGLAVSAD 422 H++ + G+ S G +D++ + S + + + + S Sbjct: 215 GHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNL 274 Query: 423 GDIAVAACYKHIAIY---SHGKLTEVPISYNSSCVALSNDKQFVAV--GGQDSKVHVYKL 477 K I + + ++ V + + S + + G D+ + ++ Sbjct: 275 LATGGGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSY 334 Query: 478 SGASVS-EVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHT 529 S + ++ +V H + A S +G L + + V + + Sbjct: 335 SSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHVKRP 387 Score = 34.5 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 15/85 (17%), Positives = 28/85 (32%), Gaps = 5/85 (5%) Query: 17 ARGTAVVLGNTPAGDKIQY-----CNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSG 71 A L +P +I N S+++ LT H + + SP G Sbjct: 302 AGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDG 361 Query: 72 YYCASGDVHGNVRIWDTTQTTHILK 96 ++ N++ W H+ + Sbjct: 362 RILSTAASDENLKFWRVYDGDHVKR 386 >4XFV-A nrPDB Length = 792 Score = 148 bits (374), Expect = 5e-36, Method: Composition-based stats. Identities = 101/681 (14%), Positives = 198/681 (29%), Gaps = 148/681 (21%) Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHI-LKTTIPVFSGPVKDISWDS 113 H + T + P + S +V+IW T +H+ TI +S + +S Sbjct: 59 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP 118 Query: 114 ESKRIAAVGEGRERFGHVFLFDTGTSNGNL-TGQARAMNSVDFKP---------SRPFRI 163 + +VG G + ++ N + F P + + + Sbjct: 119 ---SLISVG---CADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLL 172 Query: 164 ISGSDDNTVAIFE-------GPPFKFKSTFGEHTKFVHSVRY----NPDGSLFASTGGDG 212 G + V I + + H +V S+ + P L S D Sbjct: 173 AIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDR 232 Query: 213 TIVLYNGVDGTKTGVFEDDSLK--------------------------NVAHSGSVFGLT 246 I L+ E+DS K + H + L Sbjct: 233 YIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQ 292 Query: 247 WSPDGTKIASASADKTIKIWN--------VATLKVEKTIPVGTRIEDQQLGIIWTK---- 294 W ++ +A+AD ++ +W V +L++ + G G W+ Sbjct: 293 WHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFT 352 Query: 295 ----QALVSISANGFINFVNPELGSIDQVR---YGHNKAITALSSSADGKTLFSADAEGH 347 ++ G + I R G K +T ++ S G+ L + + Sbjct: 353 HERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQT 412 Query: 348 INS---WDISTGISNRVFPDVH---ATMITGIKTTSKGDLFTVSWDDHLKVVPAGGS--- 398 W R H I G D+ V + V G Sbjct: 413 TRLFAPWIYDASGRKREIATWHEFSRPQIHGY------DMICVETVTDTRFVSGGDEKIL 466 Query: 399 -----------------GVDSSKAVANKLSSQPLGLAVSADGDIAVA------------- 428 G+ + S+ L +S A Sbjct: 467 RSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKE 526 Query: 429 --ACYKHIAIYSHGKLTE--------------VPISYNSSCVALSNDKQFVAVGGQDSK- 471 +++ + + + +C+ +S D++ +A + + Sbjct: 527 TPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNV 586 Query: 472 ----VHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRK--VIPYSVANNFE 525 + ++ + H IT + FS +G FL++ + RK + ++ +N Sbjct: 587 QNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTF 646 Query: 526 LAHTNSWTFHTAKVACVSWSPD--NVRLATGSLDNSVIVWNM-NKPSDHPIIIKGAHAMS 582 + HT + W+P T S D +V VW +P+D ++ Sbjct: 647 ELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTK 706 Query: 583 SVNSVIWLN----ETTIVSAG 599 +V ++ + E ++S G Sbjct: 707 AVTAISIHDSMIREKILISVG 727 Score = 122 bits (305), Expect = 5e-28, Method: Composition-based stats. Identities = 72/454 (15%), Positives = 145/454 (31%), Gaps = 58/454 (12%) Query: 162 RIISGSDDNTVAIFEGPPFKFK---STFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN 218 +I++ T+A+++ K +T H V VR+ PD S D + ++ Sbjct: 32 KIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 91 Query: 219 GVDGTKTGVFEDDSLKNVAH-SGSVFGLTWSPDGTKIASASADKTIKIWNV----ATLKV 273 D + ++ + H S ++ L+ P + I+ AD TI IW + Sbjct: 92 FTDYSHLQC-----IQTIQHYSKTIVALSALP--SLISVGCADGTISIWRQNIQNDEFGL 144 Query: 274 EKTIPVGTRIEDQ---QLGIIWTKQALVSISANGFINFV--------NPELGSIDQVRYG 322 + L + K+ L++I F+ E + G Sbjct: 145 AHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEG 204 Query: 323 HNKAITALSS----SADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSK 378 H + +L+ + L S + +I W I N + D ++K Sbjct: 205 HEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRI---NDLIDDSEEDSKKLTLLSNK 261 Query: 379 GDLFTVSWDDHLKV-VPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIY 437 F + + + + A G D + S+ LA +AD + V + I+ Sbjct: 262 QYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIW 321 Query: 438 SHG-KLTEVPISYNSSCVALSND-----------KQFVAVGGQDSKVHVYKLSGA--SVS 483 +L E+ S+ S F G+ ++ Sbjct: 322 VCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQ 381 Query: 484 EVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSV---------ANNFELAHTNSWTF 534 + ++T +A+S +G +L+AT + ++ + Sbjct: 382 RLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQI 441 Query: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKP 568 H + CV D +G + + +++ K Sbjct: 442 HGYDMICVETVTDTR-FVSGGDEKILRSFDLPKG 474 Score = 104 bits (259), Expect = 1e-22, Method: Composition-based stats. Identities = 73/483 (15%), Positives = 147/483 (30%), Gaps = 112/483 (23%) Query: 116 KRIAAVGEGRERFGHVFLFDTGTSN-----GNLTGQARAMNSVDFKPSRPFRIISGSDDN 170 K+I A G G+ + L+D N L G + V F P F ++S S+D+ Sbjct: 31 KKIVAFGAGKT----IALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDF-MVSASEDH 85 Query: 171 TVAIF---EGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN--------- 218 V I+ + + T ++K + ++ P SL + DGTI ++ Sbjct: 86 HVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP--SLISVGCADGTISIWRQNIQNDEFG 143 Query: 219 -----------------------------GVDGTKTGVFEDDSL-------------KNV 236 + GT VF + + Sbjct: 144 LAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELE 203 Query: 237 AHSGSVFGLTW----SPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW 292 H V L + +P + S S D+ I++W + + ++ +L ++ Sbjct: 204 GHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSK----KLTLLS 259 Query: 293 TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 KQ I + + + + + GH+ I++L L +A A+ + W+ Sbjct: 260 NKQYKFQI--DDELRV----GINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWE 313 Query: 353 ISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSS 412 + I + + G++ + A GS + Sbjct: 314 P-----------DETSGIW-VCSLRLGEMSSKGAS------TATGSSGGFWSCLWFTHER 355 Query: 413 QPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKV 472 L G + A + I +L + + + +A S +++ D Sbjct: 356 MDFFLTNGKTGSWRMWATKDN--IICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTT 413 Query: 473 H-----VYKLSGASVSEVKTIV------HPAEITSVAFSNNGAFLVATDQSRKVIPYSVA 521 +Y SG H ++ V + F V+ + + + + Sbjct: 414 RLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRF-VSGGDEKILRSFDLP 472 Query: 522 NNF 524 Sbjct: 473 KGV 475 Score = 98.8 bits (244), Expect = 6e-21, Method: Composition-based stats. Identities = 64/451 (14%), Positives = 130/451 (28%), Gaps = 64/451 (14%) Query: 209 GGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNV 268 G TI L++ ++ GV+ H V + + PD + SAS D +KIW Sbjct: 37 GAGKTIALWDPIEPNNKGVYA----TLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 92 Query: 269 ATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFV----NPELGSIDQVRYGHN 324 + I + + + A+G I+ + + Sbjct: 93 TDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKK 152 Query: 325 KAITALSSS-----ADGKTLFSADAEGHI----NSWDISTGISNRVF--PDVHATMITGI 373 L S L ++ S RV + H + + Sbjct: 153 GFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSL 212 Query: 374 KTT---SKGDLFTVSWDD----HLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIA 426 + GD S L + DS + D ++ Sbjct: 213 AFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELR 272 Query: 427 VAACYKHIAI----------YSHGKLTEVPISYNSSCVALSND---KQFVAVGGQDSKVH 473 V ++ + + + +L + + ++S + D +V + Sbjct: 273 VGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCS------LR 326 Query: 474 VYKLSGASVSEVKTIVHPAEITSVAFSNNGA--FLVATDQSRKVIPYSVANNFELAHTNS 531 + ++S S S + + F + ++ ++ +N Sbjct: 327 LGEMSSKGAST--ATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLG 384 Query: 532 WTFHTAKVACVSWSPDNVRLATGSLDNSVIV---WNMNKPSDHPIIIK---------GAH 579 + T V ++WSP L SLD + + W + I + Sbjct: 385 ISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGY 444 Query: 580 AMSSVNSVIWLNETTIVSAGQDSNIKFWNVP 610 M V +V +T VS G + ++ +++P Sbjct: 445 DMICVETV---TDTRFVSGGDEKILRSFDLP 472 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 46/245 (18%), Positives = 92/245 (37%), Gaps = 30/245 (12%) Query: 49 LTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGN-----VRIWDTTQTTHILKTTIPVFS 103 + E H + T SP AS N +RI+ +T+ +K +P S Sbjct: 552 WPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIF-STENWLEIKPALPFHS 610 Query: 104 GPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSN-----GNLTGQARAMNSVDFKP- 157 + + + + K + +V R+R ++ + + N R + D+ P Sbjct: 611 LTITRLKFSKDGKFLLSV--CRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 668 Query: 158 SRPFRIISGSDDNTVAIFE-----GPPFKFKSTFGEHTKFVHSVRYNPD---GSLFASTG 209 ++ S D TV ++ + +++ HTK V ++ + + S G Sbjct: 669 EFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIK-HTKAVTAISIHDSMIREKILISVG 727 Query: 210 -GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS---PDGTKIA-SASADKTIK 264 +G I LY+ G + + + A + L WS +G S+D + + Sbjct: 728 LENGEIYLYSYTLGKFELITQLNEDITPA--DKITRLRWSHLKRNGKLFLGVGSSDLSTR 785 Query: 265 IWNVA 269 I+++A Sbjct: 786 IYSLA 790 Score = 59.9 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 22/103 (21%), Positives = 39/103 (37%), Gaps = 3/103 (2%) Query: 506 LVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM 565 +VA + + + + H A+V CV + PD+ + + S D+ V +W Sbjct: 33 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 92 Query: 566 NKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAG-QDSNIKFW 607 S I H ++ V +++S G D I W Sbjct: 93 TDYSHLQCIQTIQHYSKTI--VALSALPSLISVGCADGTISIW 133 Score = 50.6 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 73/527 (13%), Positives = 141/527 (26%), Gaps = 136/527 (25%) Query: 56 TEHSHQTTVAKT--SPSGYYCASGDVHGNVRIWDTTQTTH-ILKTTIPVFSGPVKDISWD 112 T S + + G+ R+W T + I + V DI+W Sbjct: 339 TGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWS 398 Query: 113 SESKRIAAVG-EGRERFGHVFLFDTGTSNGNLTG---------QARAMNSVDFKPSRPFR 162 + + A + R +++D + M V+ R Sbjct: 399 PSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDT--R 456 Query: 163 IISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTG------------- 209 +SG D + F + +++ + S Sbjct: 457 FVSGG-DEKI----LRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGED 511 Query: 210 -------------------GD--GTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 D + D + + + K H + L S Sbjct: 512 DANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDIS 571 Query: 249 PDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINF 308 PD IASA ++ + S ++ Sbjct: 572 PDQKLIASACRSNNVQ-----------------------------NAVIRIFSTENWL-- 600 Query: 309 VNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHAT 368 I H+ IT L S DGK L S + W+ + + F Sbjct: 601 ------EIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWE--RNMEDNTFE----- 647 Query: 369 MITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVA 428 ++ ++ + WD L + + S D + V Sbjct: 648 ----LRFKNEKPHTRIIWDAD-----------------WAPLEFGNVFVTASRDKTVKV- 685 Query: 429 ACYKHIAIYSHGKLTEVPISYNSSCVALS------NDKQFVAVGGQDSKVHVYKLSGASV 482 ++H + + E I + + A+S +K ++VG ++ ++++Y + Sbjct: 686 --WRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKF 743 Query: 483 SEV----KTIVHPAEITSVAFS----NNGAFLVATDQSRKVIPYSVA 521 + + I +IT + +S N FL YS+A Sbjct: 744 ELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSLA 790 >5WJC-A nrPDB Length = 430 Score = 142 bits (357), Expect = 5e-34, Method: Composition-based stats. Identities = 41/259 (15%), Positives = 96/259 (37%), Gaps = 24/259 (9%) Query: 30 GDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPS--GYYCASGDVHGNVRIWD 87 G+ + + G + H+ + +P+ G A+G + +WD Sbjct: 154 GNAYIFDTTCHD-ALTTGEALPQAVLKGHTAEGFGLCWNPNLPGN-LATGAEDQVICLWD 211 Query: 88 TTQTTHILKTTIPV--------FSGPVKDISWDSESK-RIAAVGEGRERFGHVFLFDTGT 138 + T + + V D+ + + + +A+V + H + Sbjct: 212 VQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEE 271 Query: 139 SN-GNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPP-FKFKSTFGEHTKFVHSV 196 + ++A+N+V P + + + S D TVA+++ ++ T H V+ + Sbjct: 272 EAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDLRNPYQRLHTLEGHEDEVYGL 331 Query: 197 RYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV-------AHSGSVFGLTWS 248 ++P D + AS+ D + +++ + ED + H+ + +W Sbjct: 332 EWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWC 391 Query: 249 PDGTKIA-SASADKTIKIW 266 P+ + S + D ++IW Sbjct: 392 PNERWVVGSLADDNILQIW 410 Score = 128 bits (321), Expect = 7e-30, Method: Composition-based stats. Identities = 58/294 (19%), Positives = 116/294 (39%), Gaps = 51/294 (17%) Query: 102 FSGPVKDISWDSES-KRIAAVGEGRERFGHVFLFDTGTSNG----------NLTGQARAM 150 G V + + + IA +GEG G+ ++FDT + L G Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEG----GNAYIFDTTCHDALTTGEALPQAVLKGHTAEG 185 Query: 151 NSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKST----------FGEHTKFVHSVRYNP 200 + + P+ P + +G++D + +++ F S+ + HT V+ V+++P Sbjct: 186 FGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHP 245 Query: 201 DGS-LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP-DGTKIASAS 258 L AS D T+ +++ T+ E+ AHS ++ + +P + +A+AS Sbjct: 246 QHEALLASVSDDCTLQIHD----TRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATAS 301 Query: 259 ADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQ---ALVSISANGFINFVNPE--- 312 ADKT+ +W++ + + ED+ G+ W+ L S S + + + E Sbjct: 302 ADKTVALWDLRN--PYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIG 359 Query: 313 -----------LGSIDQVRYGHNKAITALSSSADGKTLF-SADAEGHINSWDIS 354 + + GH I+ S + + + S + + W S Sbjct: 360 EEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIWSPS 413 Score = 90.7 bits (223), Expect = 2e-18, Method: Composition-based stats. Identities = 48/261 (18%), Positives = 94/261 (36%), Gaps = 17/261 (6%) Query: 189 HTKFVHSVRYNPD-GSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV-AHSGSVFGLT 246 H V+ RY P + A+ G G +++ E + H+ FGL Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 247 WSPDGT-KIASASADKTIKIWNVAT-------LKVEKTIPVGTRIEDQQLGIIWTKQA-- 296 W+P+ +A+ + D+ I +W+V T KV I R D + + Q Sbjct: 190 WNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEA 249 Query: 297 -LVSISANGFINFVNPELGSID---QVRYGHNKAITALSSSA-DGKTLFSADAEGHINSW 351 L S+S + + + L + +V H+KAI A++ + + L +A A+ + W Sbjct: 250 LLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALW 309 Query: 352 DISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLS 411 D+ + H + G++ + + S +V + + + Sbjct: 310 DLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAED 369 Query: 412 SQPLGLAVSADGDIAVAACYK 432 P L + ++ Sbjct: 370 GSPELLFMHGGHTNRISEFSW 390 Score = 88.0 bits (216), Expect = 1e-17, Method: Composition-based stats. Identities = 33/183 (18%), Positives = 64/183 (34%), Gaps = 16/183 (8%) Query: 440 GKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV---------H 490 L C + +A G +D + ++ + S + +T V H Sbjct: 176 AVLKGHTAEGFGLCWNPNLPGN-LATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRH 234 Query: 491 PAEITSVAFSN-NGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNV 549 + V F + A L + + + N E H+ + V+ +P N Sbjct: 235 TDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFND 294 Query: 550 RL-ATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWL--NETTIVSAGQDSNIKF 606 L AT S D +V +W++ P + + V + W +E + S+ D + Sbjct: 295 YLLATASADKTVALWDLRNP--YQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCI 352 Query: 607 WNV 609 W++ Sbjct: 353 WDL 355 Score = 85.7 bits (210), Expect = 6e-17, Method: Composition-based stats. Identities = 47/313 (15%), Positives = 96/313 (30%), Gaps = 60/313 (19%) Query: 323 HNKAITALSSSADG-KTLFSADAEGHINSWD------ISTGISN-RVFPDVHATMITGIK 374 H+ + + + + G+ +D ++TG + + H G+ Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 375 TTSK--GDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYK 432 G+L T + D + + SS+ +A ++ Sbjct: 190 WNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVIS----------------PIAKYHR 233 Query: 433 HIAIYSHGKLTEVPISYNSSCVALSNDKQ-FVAVGGQDSKVHVYK--LSGASVSEVKTIV 489 H I + V + +A D + ++ L+ + Sbjct: 234 HTDIVND--------------VQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQA 279 Query: 490 HPAEITSVAFSN-NGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP-D 547 H I +VA + N L + V + + N ++ HT H +V + WSP D Sbjct: 280 HSKAINAVAINPFNDYLLATASADKTVALWDLRNPYQRLHT--LEGHEDEVYGLEWSPHD 337 Query: 548 NVRLATGSLDNSVIVWNMNKPSDHPI-----------IIKGAHAMSSVNSVIWLNETTIV 596 LA+ S D V +W++ K + + + ++ W V Sbjct: 338 EPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWV 397 Query: 597 SAG--QDSNIKFW 607 D+ ++ W Sbjct: 398 VGSLADDNILQIW 410 >6BX3-A nrPDB Length = 314 Score = 141 bits (355), Expect = 9e-34, Method: Composition-based stats. Identities = 59/306 (19%), Positives = 113/306 (36%), Gaps = 23/306 (7%) Query: 63 TVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVG 122 T AK SP G + A + I+D + T + +T + + P ++ W + + IA Sbjct: 16 TCAKISPDGQFLAITQGLN-ILIYDINRRT-VSQTLVTSHARPFSELCWSPDGQCIATAS 73 Query: 123 EGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKF 182 + F + + G + S+ F + + + S D ++ I++ Sbjct: 74 DD---FSVEIIHLSYGLLHTFIGHTAPVISLTFN-RKGNLLFTSSMDESIKIWDTLNGSL 129 Query: 183 KSTFGEHTKFVHSVRY-NPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDD-SLKNVAHSG 240 T H++ V SV D S+ +S DG I +++ G D K Sbjct: 130 MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVV 189 Query: 241 SVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTI---PVGTRIEDQQLGIIW----- 292 + + +S + + S D +KIW+ V +T P+ + G+ + Sbjct: 190 PISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPED 249 Query: 293 -TKQALVSISANGFINFVNPELGSIDQVRYG----HNKAITALSSSADGKTLFSADAEGH 347 + ++S NG I N + S+ Q+ G H+ + ++ G + S G Sbjct: 250 GSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHC--FGNIMCSLALNGD 307 Query: 348 INSWDI 353 W Sbjct: 308 CCLWRW 313 Score = 119 bits (298), Expect = 4e-27, Method: Composition-based stats. Identities = 51/303 (16%), Positives = 108/303 (35%), Gaps = 28/303 (9%) Query: 27 TPAGDKIQYCNGTSV--YTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVR 84 +P G + G ++ Y + +++ T + T H+ + SP G A+ +V Sbjct: 21 SPDGQFLAITQGLNILIYDINRRTVSQT-LVTSHARPFSELCWSPDGQCIATASDDFSVE 79 Query: 85 IWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDT--GTSNGN 142 I + L T + PV ++++ + + + ++DT G+ Sbjct: 80 IIHLSYG---LLHTFIGHTAPVISLTFNRKGNLLFTSSMDES----IKIWDTLNGSLMKT 132 Query: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKF--------VH 194 ++ + A+ SVD + + SGS D + IF+ T + + Sbjct: 133 ISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPIS 192 Query: 195 SVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSL-KNVAHSGSVFGLTW-SP--- 249 V+++ + DG + +++ + G F+ L K V H G+ + +P Sbjct: 193 QVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHS--CGMDFLNPEDG 250 Query: 250 DGTKIASASADKTIKIWNVATLKVEKTIPVG-TRIEDQQLGIIWTKQALVSISANGFINF 308 + S + I WN T + + + + I + S++ NG Sbjct: 251 STPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCL 310 Query: 309 VNP 311 Sbjct: 311 WRW 313 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 35/159 (22%), Positives = 77/159 (48%), Gaps = 8/159 (5%) Query: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATD 510 ++C +S D QF+A+ Q + +Y ++ +VS+ H + + +S +G + Sbjct: 15 ATCAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATAS 73 Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 V ++ +++ HTA V ++++ L T S+D S+ +W+ S Sbjct: 74 DDFSVEIIHLSYGL----LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSL 129 Query: 571 HPIIIKGAHAMSSVNSVIWLNETTIVSAG-QDSNIKFWN 608 I AH+ + V+ + +N+++I+S+G D I+ ++ Sbjct: 130 MKTIS--AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFD 166 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 42/221 (19%), Positives = 77/221 (34%), Gaps = 19/221 (8%) Query: 151 NSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTF-GEHTKFVHSVRYNPDGSLFASTG 209 P F I+ + I++ T H + + ++PDG A+ Sbjct: 16 TCAKISPDGQFLAITQGL--NILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATAS 73 Query: 210 GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVA 269 D ++ + + G + H+ V LT++ G + ++S D++IKIW+ Sbjct: 74 DDFSVEIIHLSYGL--------LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTL 125 Query: 270 TLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKA--- 326 + KTI + + L S S +G I + E G + Sbjct: 126 NGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRE 185 Query: 327 -----ITALSSSADGKTLFSADAEGHINSWDISTGISNRVF 362 I+ + S + + L +G + WD G R F Sbjct: 186 NGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTF 226 Score = 103 bits (257), Expect = 2e-22, Method: Composition-based stats. Identities = 55/336 (16%), Positives = 113/336 (33%), Gaps = 47/336 (13%) Query: 194 HSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTK 253 + +PDG A T G I++Y+ T + +H+ L WSPDG Sbjct: 16 TCAKISPDGQFLAITQG-LNILIYDINRRTVSQTL------VTSHARPFSELCWSPDGQC 68 Query: 254 IASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPEL 313 IA+AS D +++I +++ + +G L L + S + I + Sbjct: 69 IATASDDFSVEIIHLSYGLLH--TFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLN 126 Query: 314 GSIDQVRYGHNKAITALS-SSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITG 372 GS+ + H++A+ ++ D L S +G I +D TG + Sbjct: 127 GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLT--------- 177 Query: 373 IKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYK 432 + W VVP + L S DG + + C Sbjct: 178 ---------YDKDWKRENGVVPISQ---------VKFSENARYLLVKSLDGVVKIWDCIG 219 Query: 433 H--IAIYSHGKLTEVPISYNSSCVALSND---KQFVAVGGQDSKVHVYKLSGASVSEVKT 487 + + L + + ++ L+ + V G ++ ++ + S+ ++ Sbjct: 220 GCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLD 279 Query: 488 IV---HPAEITSVAFSNNGAFLVATDQSRKVIPYSV 520 H + + ++ G + + + + Sbjct: 280 GSLYHHSSPV--MSIHCFGNIMCSLALNGDCCLWRW 313 Score = 93.0 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 40/332 (12%), Positives = 99/332 (29%), Gaps = 47/332 (14%) Query: 243 FGLTWSPDGTKIA-SASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSIS 301 SPDG +A + I I+++ V +T+ +L Q + + S Sbjct: 16 TCAKISPDGQFLAITQGL--NILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATAS 73 Query: 302 ANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRV 361 + + ++ G + GH + +L+ + G LF++ + I WD G + Sbjct: 74 DDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKT 132 Query: 362 FPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSA 421 H+ + + S + K + Sbjct: 133 I-SAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKD------WKRE 185 Query: 422 DGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGAS 481 +G + ++ V S + +++ V D V ++ G Sbjct: 186 NGVVPISQ------------------------VKFSENARYLLVKSLDGVVKIWDCIGGC 221 Query: 482 VSEVKT--IVHPAEITSVA----FSN---NGAFLVATDQSRKVIPYSVANNFELAHTN-S 531 V + + + + +++ ++ + ++ L + S Sbjct: 222 VVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGS 281 Query: 532 WTFHTAKVACVSWSPDNVRLATGSLDNSVIVW 563 H++ V + + + +L+ +W Sbjct: 282 LYHHSSPVMSI--HCFGNIMCSLALNGDCCLW 311 Score = 87.6 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 50/277 (18%), Positives = 91/277 (32%), Gaps = 36/277 (12%) Query: 13 LPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGY 72 + AR + L +P G I + + S + H+ + G Sbjct: 50 VTSHARPFS-ELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGN 108 Query: 73 YCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVF 132 + + +++IWDT + L TI S V + I + G + +F Sbjct: 109 LLFTSSMDESIKIWDTLNGS--LMKTISAHSEAVVSVDVPMNDSSILSSGS-YDGLIRIF 165 Query: 133 LFDTGTSNGNLTGQARA--------MNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKS 184 +TG LT ++ V F + + ++ S D V I++ Sbjct: 166 DAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVK-SLDGVVKIWDCIGGCVVR 224 Query: 185 TFG---------EHTKFVHSVRY-NP-DGS--LFASTGGDGTIVLYNGVDGTKTGVFEDD 231 TF H+ + + NP DGS L S +G I +N + + + Sbjct: 225 TFQVQPLEKGVLHHS---CGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGS 281 Query: 232 SLKNVAHSGSVFGL-TWSPDGTKIASASADKTIKIWN 267 HS V + + G + S + + +W Sbjct: 282 LYH---HSSPVMSIHCF---GNIMCSLALNGDCCLWR 312 Score = 74.5 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 33/258 (12%), Positives = 75/258 (29%), Gaps = 21/258 (8%) Query: 371 TGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAAC 430 T K + G ++ ++ + V + ++ L S DG A Sbjct: 16 TCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSE--LCWSPDGQCIATAS 73 Query: 431 YK---HIAIYSHGKLTEV-PISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVK 486 I S+G L + + + + D + ++ S+ + Sbjct: 74 DDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTI 133 Query: 487 TIVHPAEITSVAFS-NNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAK-----VA 540 + H + SV N+ + L + + + L + ++ Sbjct: 134 S-AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPIS 192 Query: 541 CVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLN--------E 592 V +S + L SLD V +W+ ++ ++ Sbjct: 193 QVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGST 252 Query: 593 TTIVSAGQDSNIKFWNVP 610 ++S ++ +I WN Sbjct: 253 PLVISGYENGDIYCWNSD 270 >5OQL-d nrPDB Length = 446 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 49/302 (16%), Positives = 104/302 (34%), Gaps = 16/302 (5%) Query: 316 IDQVRYGHNKAITALSSSADG-KTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIK 374 + Q+ GH + + ++ + + S +G + WD++T H ++ G+ Sbjct: 58 LGQLGNGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLT 117 Query: 375 TTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHI 434 T+ L + + D P + A + + A ++ I Sbjct: 118 FTNDKKLLSCATDGIKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCI 177 Query: 435 AIYSHGKLT-------EVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKT 487 I+ T + + + + D + ++ L +KT Sbjct: 178 RIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPV-IKT 236 Query: 488 IVHPAEITSVAFSNNGAF-LVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP 546 ++H A + F+ A L + + + N + N H A V V +SP Sbjct: 237 VLHFA-CNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKA--LNIQKGHVAAVMDVEFSP 293 Query: 547 DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW-LNETTIVSAGQDSNIK 605 L +GS D ++ +W + + H + M V +W ++ I++ D N++ Sbjct: 294 TGEELVSGSYDRTIRLW--RRDAGHSRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGNVR 351 Query: 606 FW 607 W Sbjct: 352 LW 353 Score = 121 bits (302), Expect = 1e-27, Method: Composition-based stats. Identities = 53/312 (16%), Positives = 106/312 (33%), Gaps = 27/312 (8%) Query: 52 TEIYTEHSHQTTVAKTSPSG-YYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDIS 110 ++ H + ASG G V++WD T + + VK ++ Sbjct: 59 GQLGNGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWR-VAAHNNIVKGLT 117 Query: 111 WDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTG-----QARAMNSVDFKPSRPFRIIS 165 + ++ K ++ +G + L+D S N T + S+ F + Sbjct: 118 FTNDKKLLSCATDG------IKLWDPYASPSNTTPIATWQEGGPYTSLSFH-RSANTFAA 170 Query: 166 GSDDNTVAIFEGPPFKFKSTFGEHT--KFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDG 222 S + I++ + + V +N + S+ S D +I+L++ Sbjct: 171 SSGQGCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTN 230 Query: 223 TKTGVFEDDSLKNVAHSGSVFGLTWSPDGTK-IASASADKTIKIWNVATLKVEKTIPVGT 281 +K V H + + ++P +A AS D I I++ I G Sbjct: 231 -------MPVIKTVLH-FACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGH 282 Query: 282 RIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHN-KAITALSSSADGKTLF 340 + T + LVS S + I + G V + + + + D K + Sbjct: 283 VAAVMDVEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQRVFRTMWTMDSKYIL 342 Query: 341 SADAEGHINSWD 352 + +G++ W Sbjct: 343 TGSDDGNVRLWR 354 Score = 111 bits (276), Expect = 1e-24, Method: Composition-based stats. Identities = 48/244 (19%), Positives = 78/244 (31%), Gaps = 57/244 (23%) Query: 30 GDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTT 89 G K+ + T P+ + + YT S S A+ G +RIWD Sbjct: 131 GIKLWDPYASPSNTTPIATWQEGGPYTSLS-------FHRSANTFAASSGQGCIRIWDLE 183 Query: 90 QTTHILKTTIPVFSGPVKDISWDS-ESKRIAAVGEGRERFGHVFLFDTGTSNGNL-TGQA 147 +T P F + D+ ++ E+ I +V R + LFD T+ + T Sbjct: 184 HSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRS----IILFDLRTNMPVIKTVLH 239 Query: 148 RAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPF-KFKSTFGEHTKFVHSVRYNPDGSLFA 206 A N + F P + S+D+ + IF+ F K + H V V ++P G Sbjct: 240 FACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEELV 299 Query: 207 STG-------------------------------------------GDGTIVLYNGVDGT 223 S DG + L+ Sbjct: 300 SGSYDRTIRLWRRDAGHSRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGNVRLWRANASE 359 Query: 224 KTGV 227 ++GV Sbjct: 360 RSGV 363 Score = 110 bits (275), Expect = 2e-24, Method: Composition-based stats. Identities = 39/268 (14%), Positives = 85/268 (31%), Gaps = 13/268 (4%) Query: 51 DTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSG-PVKDI 109 +T H++ + + G +++WD + G P + Sbjct: 102 ETWRVAAHNNIVKGLTFTNDKKLLSCAT-DG-IKLWDPYASPSNTTPIATWQEGGPYTSL 159 Query: 110 SWDSESKRIA-AVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSD 168 S+ + A + G+G R + G + + V F I S + Sbjct: 160 SFHRSANTFAASSGQGCIRIWDLEHSTAGQAI-QWPSFVDTITDVCFNQVETSVIGSVAT 218 Query: 169 DNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGV 227 D ++ +F+ H + + +NP + A D I +++ + Sbjct: 219 DRSIILFDLRTNMPVIKTVLHFA-CNRIVFNPMEAMNLAVASEDHNIYIFDARN------ 271 Query: 228 FEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQ 287 F+ H +V + +SP G ++ S S D+TI++W + Sbjct: 272 FDKALNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQRVFR 331 Query: 288 LGIIWTKQALVSISANGFINFVNPELGS 315 + +++ S +G + Sbjct: 332 TMWTMDSKYILTGSDDGNVRLWRANASE 359 Score = 109 bits (272), Expect = 4e-24, Method: Composition-based stats. Identities = 40/297 (13%), Positives = 89/297 (29%), Gaps = 12/297 (4%) Query: 237 AHSGSVFGLTWSPDG-TKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQ 295 H V+ + + IAS S D +K+W++ T E + L K+ Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTNDKK 123 Query: 296 ALVSISANGFINFVNPELGSIDQVRYG---HNKAITALSSSADGKTLFSADAEGHINSWD 352 L+S + +G I +P + T+LS T ++ +G I WD Sbjct: 124 -LLSCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWD 181 Query: 353 ISTGISNR-VFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLS 411 + + + + IT + S ++ + Sbjct: 182 LEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHFA 241 Query: 412 SQPLGLAVSADGDIAVAACYKHIAIYS-----HGKLTEVPISYNSSCVALSNDKQFVAVG 466 + ++AVA+ +I I+ + V S + + G Sbjct: 242 CNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEELVSG 301 Query: 467 GQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANN 523 D + +++ +V + ++ + +++ V + + Sbjct: 302 SYDRTIRLWRRDAGHSRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGNVRLWRANAS 358 Score = 104 bits (259), Expect = 1e-22, Method: Composition-based stats. Identities = 43/357 (12%), Positives = 107/357 (29%), Gaps = 53/357 (14%) Query: 144 TGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKS-TFGEHTKFVHSVRYNPDG 202 G + + S+ + I SGS D V +++ ++ H V + + + Sbjct: 63 NGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFT-ND 121 Query: 203 SLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKT 262 S DG I L++ + + + + L++ A++S Sbjct: 122 KKLLSCATDG-IKLWDPYA-SPSNTTPIATWQEGG---PYTSLSFHRSANTFAASSGQGC 176 Query: 263 IKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK---QALVSISANGFINFVNPELGSIDQV 319 I+IW++ + I + D + + + + S++ + I + Sbjct: 177 IRIWDLEHSTAGQAIQWPS-FVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIK 235 Query: 320 RYGHNKAITALSSSADGKT-LFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSK 378 H A + + L A + +I +D H + ++ + Sbjct: 236 TVLH-FACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPT 294 Query: 379 G-DLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIY 437 G +L + S+D +++ + ++ + Sbjct: 295 GEELVSGSYDRTIRLWRRDAGHSRDVYHTK------------------RMQRVFRTM--- 333 Query: 438 SHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEI 494 + D +++ G D V +++ + + S VK + Sbjct: 334 ------------------WTMDSKYILTGSDDGNVRLWRANASERSGVKATRQRQAL 372 Score = 103 bits (257), Expect = 2e-22, Method: Composition-based stats. Identities = 46/287 (16%), Positives = 91/287 (31%), Gaps = 17/287 (5%) Query: 293 TKQALVSISANGFINFVNPELGSIDQVR-YGHNKAITALSSSADGKTLFSADAEGHINSW 351 + + S S +G + + + R HN + L+ + D K L S +G I W Sbjct: 78 SLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTND-KKLLSCATDG-IKLW 135 Query: 352 DI--STGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANK 409 D S + + T + + F S + Sbjct: 136 DPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWDLEHSTAGQAIQWPS 195 Query: 410 LSSQPLGLAVSADGDIAVAACYKHIAI------YSHGKLTEVPISYNSSCVALSNDKQFV 463 + + + + +I + + V + V + + Sbjct: 196 FVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHFACNRIVFNPMEAMNL 255 Query: 464 AVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPY--SVA 521 AV +D ++++ + H A + V FS G LV+ R + + Sbjct: 256 AVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLWRRDAG 315 Query: 522 NNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKP 568 ++ ++ HT +V W+ D+ + TGS D +V +W N Sbjct: 316 HSRDVYHTKRMQ----RVFRTMWTMDSKYILTGSDDGNVRLWRANAS 358 Score = 101 bits (252), Expect = 7e-22, Method: Composition-based stats. Identities = 45/311 (14%), Positives = 104/311 (33%), Gaps = 20/311 (6%) Query: 100 PVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNG-NLTGQARAMNSVDFKPS 158 V + D S A G G + V+ T + + + F + Sbjct: 63 NGHVQGVYSMCKDKNSLNCIASGSG-DGVVKVWDLTTRDEETWRVAAHNNIVKGLTF--T 119 Query: 159 RPFRIISGSDDNTVAIFEG----PPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTI 214 +++S + D + +++ +T+ E S+ ++ + FA++ G G I Sbjct: 120 NDKKLLSCATDG-IKLWDPYASPSNTTPIATWQE-GGPYTSLSFHRSANTFAASSGQGCI 177 Query: 215 VLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP-DGTKIASASADKTIKIWNVATLKV 273 +++ T +++ + ++ + ++ + + I S + D++I ++++ T Sbjct: 178 RIWDLEHST-----AGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRT--N 230 Query: 274 EKTIPVGTRIEDQQLGIIWTKQ-ALVSISANGFINFVNPEL-GSIDQVRYGHNKAITALS 331 I ++ + L S + I + ++ GH A+ + Sbjct: 231 MPVIKTVLHFACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVE 290 Query: 332 SSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLK 391 S G+ L S + I W G S V+ + T DD Sbjct: 291 FSPTGEELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGNV 350 Query: 392 VVPAGGSGVDS 402 + + S Sbjct: 351 RLWRANASERS 361 Score = 54.9 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 18/123 (14%), Positives = 41/123 (33%), Gaps = 6/123 (4%) Query: 489 VHPAEITSVAFSNNG-AFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPD 547 H + S+ N + + V + + E T H V ++++ D Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDE--ETWRVAAHNNIVKGLTFTND 121 Query: 548 NVRLATGSLDNSVIVWN-MNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKF 606 L + + D + +W+ PS+ I + + T ++ I+ Sbjct: 122 KKLL-SCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRI 179 Query: 607 WNV 609 W++ Sbjct: 180 WDL 182 Score = 38.3 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 10/76 (13%), Positives = 24/76 (31%), Gaps = 2/76 (2%) Query: 27 TPAGDKIQYCNGTSVYTVPVGSLTDTE--IYTEHSHQTTVAKTSPSGYYCASGDVHGNVR 84 +P G+++ + + + +T+ + + Y +G GNVR Sbjct: 292 SPTGEELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGNVR 351 Query: 85 IWDTTQTTHILKTTIP 100 +W + Sbjct: 352 LWRANASERSGVKATR 367 Score = 33.3 bits (74), Expect = 0.36, Method: Composition-based stats. Identities = 8/36 (22%), Positives = 13/36 (36%), Gaps = 2/36 (5%) Query: 576 KGAHAMSSVNSVIWLNE--TTIVSAGQDSNIKFWNV 609 G + V S+ I S D +K W++ Sbjct: 61 LGNGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDL 96 >2HES-X nrPDB Length = 330 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 56/272 (20%), Positives = 94/272 (34%), Gaps = 24/272 (8%) Query: 136 TGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTF----GEHTK 191 + +L + S DF + +GS D + + F H K Sbjct: 3 SINLIKSLKLYKEKIWSFDFSQ---GILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKK 59 Query: 192 FVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV-AHSGSVFGLTWSPD 250 + SV + P SL A+ D T+ ++ + + FE D L + H V G+ WS D Sbjct: 60 AIRSVAWRPHTSLLAAGSFDSTVSIW-AKEESADRTFEMDLLAIIEGHENEVKGVAWSND 118 Query: 251 GTKIASASADKTIKIWNVA-TLKVEKTIPVGTRIEDQQLGIIWTKQ--ALVSISANGFIN 307 G +A+ S DK++ IW + + + I V +IW L S S + + Sbjct: 119 GYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVR 178 Query: 308 FV--NPELGSIDQVRYGHNKAITALSSSADGKT--LFSADAEGHINSW--------DIST 355 + V GH + + L S + + W D Sbjct: 179 IWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQE 238 Query: 356 GISNRVFPDVHATMITGIKTTSKGDLFTVSWD 387 + + PDVH + + G + +V D Sbjct: 239 WVCEAILPDVHKRQVYNVAWGFNGLIASVGAD 270 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 49/282 (17%), Positives = 99/282 (35%), Gaps = 28/282 (9%) Query: 56 TEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQT-----THILKTTIPVFSGPVKDIS 110 T H P A+G V IW ++ L I VK ++ Sbjct: 55 TAHKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVA 114 Query: 111 WDSESKRIAAVGEGRERFGHVFLFDT------GTSNGNLTGQARAMNSVDFKPSRPFRII 164 W ++ +A + V++++T L ++ + V + PS + Sbjct: 115 WSNDGYYLATCSRDKS----VWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEAL-LA 169 Query: 165 SGSDDNTVAIFE--GPPFKFKSTFGEHTKFVHSVRYNPDGS--LFASTGGDGTIVLYN-- 218 S S D+TV I++ ++ + H V S ++ S D T+ ++ Sbjct: 170 SSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYM 229 Query: 219 GVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIP 278 G D + +++ H V+ + W +G IAS AD + ++ + + Sbjct: 230 GDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNG-LIASVGADGVLAVYEEVDGEWKVFAK 288 Query: 279 VGTRIEDQQLGIIW-----TKQALVSISANGFINFVNPELGS 315 ++ ++ K L + +G +NF + E + Sbjct: 289 RALCHGVYEINVVKWLELNGKTILATGGDDGIVNFWSLEKAA 330 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 53/271 (19%), Positives = 106/271 (39%), Gaps = 30/271 (11%) Query: 24 LGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYT--------EHSHQTTVAKTSPSGYYCA 75 + P + + S ++ + + H ++ S GYY A Sbjct: 64 VAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLA 123 Query: 76 SGDVHGNVRIWDTTQTTHILK--TTIPVFSGPVKDISWDSESKRIAAVG-EGRERFGHVF 132 + +V IW+T ++ + + + S VK + W +A+ + R + Sbjct: 124 TCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDY 183 Query: 133 LFDTGTSNGNLTGQARAMNSVDFKPSRP-FRIISGSDDNTVAIF--------EGPPFKFK 183 D L G + S DF + FR+ SGSDD+TV ++ + + + Sbjct: 184 D-DDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCE 242 Query: 184 STFGE-HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAH-SGS 241 + + H + V++V + +G L AS G DG + +Y VDG ++ + + + H Sbjct: 243 AILPDVHKRQVYNVAWGFNG-LIASVGADGVLAVYEEVDGE----WKVFAKRALCHGVYE 297 Query: 242 VFGLTW-SPDGT-KIASASADKTIKIWNVAT 270 + + W +G +A+ D + W++ Sbjct: 298 INVVKWLELNGKTILATGGDDGIVNFWSLEK 328 Score = 116 bits (289), Expect = 4e-26, Method: Composition-based stats. Identities = 46/318 (14%), Positives = 103/318 (32%), Gaps = 34/318 (10%) Query: 66 KTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIP--VFSGPVKDISWDSESKRIAAVGE 123 S A+G +++ L + ++ ++W + +AA Sbjct: 19 SFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSF 78 Query: 124 GRERFGHVFLFDTGTS-----NGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFE-- 176 + + G + V + + + + + S D +V I+E Sbjct: 79 DSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWS-NDGYYLATCSRDKSVWIWETD 137 Query: 177 --GPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLK 234 G ++ S EH++ V V ++P +L AS+ D T+ ++ D V + Sbjct: 138 ESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLN--- 194 Query: 235 NVAHSGSVFGLTWSPDGT--KIASASADKTIKIW--------NVATLKVEKTIPVGTRIE 284 H G+V+ + ++ S S D T+++W + E +P + + Sbjct: 195 --GHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQ 252 Query: 285 DQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYG------HNKAITALSSSADGKT 338 + + + S+ A+G + G + + Sbjct: 253 VYNVAWGFNG-LIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTI 311 Query: 339 LFSADAEGHINSWDISTG 356 L + +G +N W + Sbjct: 312 LATGGDDGIVNFWSLEKA 329 Score = 99.6 bits (246), Expect = 4e-21, Method: Composition-based stats. Identities = 40/155 (25%), Positives = 63/155 (40%), Gaps = 9/155 (5%) Query: 463 VAVGGQDSKVHVY--KLSGASVSEVK-TIVHPAEITSVAFSNNGAFLVATDQSRKVIPY- 518 +A G D K+ + K ++ +V H I SVA+ + + L A V + Sbjct: 27 LATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIWA 86 Query: 519 ---SVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPS-DHPII 574 S FE+ H +V V+WS D LAT S D SV +W ++ ++ I Sbjct: 87 KEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECI 146 Query: 575 IKGAHAMSSVNSVIW-LNETTIVSAGQDSNIKFWN 608 V VIW +E + S+ D ++ W Sbjct: 147 SVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWK 181 Score = 95.3 bits (235), Expect = 6e-20, Method: Composition-based stats. Identities = 37/177 (20%), Positives = 62/177 (35%), Gaps = 11/177 (6%) Query: 442 LTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVY------KLSGASVSEVKTIVHPAEIT 495 L E VA +A G DS V ++ + H E+ Sbjct: 52 LDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVK 111 Query: 496 SVAFSNNGAFLVATDQSRKVIPYSV-ANNFELAHTNSWTFHTAKVACVSWSPDNVRLATG 554 VA+SN+G +L + + V + + E + H+ V V W P LA+ Sbjct: 112 GVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASS 171 Query: 555 SLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNET---TIVSAGQDSNIKFWN 608 S D++V +W + D + +V S + + S DS ++ W Sbjct: 172 SYDDTVRIWK-DYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWK 227 Score = 78.4 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 47/307 (15%), Positives = 91/307 (29%), Gaps = 47/307 (15%) Query: 315 SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIK 374 ++ + + + I + S L + + I + D + + Sbjct: 5 NLIKSLKLYKEKIWSFDFSQ--GILATGSTDRKIKLVSVK--------YDDFTLIDVLDE 54 Query: 375 TTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHI 434 T K + +V+W H ++ AG + + + Sbjct: 55 TAHKKAIRSVAWRPHTSLLAAGSF-------------DSTVSIWAKEESADRTFEMDLLA 101 Query: 435 AIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGA----SVSEVKTIVH 490 I H VA SND ++A +D V +++ + V H Sbjct: 102 IIEGH--------ENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQE-H 152 Query: 491 PAEITSVAFSNNGAFLVATDQSRKVIPY-SVANNFELAHTNSWTFHTAKVACVSWSPDNV 549 ++ V + + A L ++ V + +++E H V + Sbjct: 153 SQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECV--AVLNGHEGTVWSSDFDKTEG 210 Query: 550 --RLATGSLDNSVIVWNMNKPSDHPII------IKGAHAMSSVNSVIWLNETTIVSAGQD 601 RL +GS D++V VW + I V +V W I S G D Sbjct: 211 VFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNGLIASVGAD 270 Query: 602 SNIKFWN 608 + + Sbjct: 271 GVLAVYE 277 Score = 74.5 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 50/312 (16%), Positives = 105/312 (33%), Gaps = 35/312 (11%) Query: 289 GIIWTKQALVSISANGFINFVNPELGSIDQVR----YGHNKAITALSSSADGKTLFSADA 344 +++ L + S + I V+ + + H KAI +++ L + Sbjct: 19 SFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSF 78 Query: 345 EGHINSWDISTGISNRVFP-------DVHATMITGIKTTSKGDLF-TVSWDDHLKVVPAG 396 + ++ W ++R F + H + G+ ++ G T S D + + Sbjct: 79 DSTVSIWA-KEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETD 137 Query: 397 GSGVD--SSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPIS--YNSS 452 SG + + + ++ +A ++ + I+ ++ Sbjct: 138 ESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHE 197 Query: 453 CVALSNDKQ------FVAVGGQDSKVHVYKLSGAS--------VSEVKTIVHPAEITSVA 498 S+D + G DS V V+K G + VH ++ +VA Sbjct: 198 GTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVA 257 Query: 499 FSNNGAFLVATDQSRKVIPYS-VANNFELAHTNSWTFHTAKVACVSWSPDN--VRLATGS 555 + NG + + + Y V +++ + ++ V W N LATG Sbjct: 258 WGFNG-LIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGG 316 Query: 556 LDNSVIVWNMNK 567 D V W++ K Sbjct: 317 DDGIVNFWSLEK 328 Score = 59.9 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 28/126 (22%), Positives = 50/126 (39%), Gaps = 8/126 (6%) Query: 491 PAEITSVAFSNNGAFLVATDQSRKVIPYSVA-NNFELAHTNSWTFHTAKVACVSWSPDNV 549 +I S FS L RK+ SV ++F L T H + V+W P Sbjct: 14 KEKIWSFDFS--QGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTS 71 Query: 550 RLATGSLDNSVIVW----NMNKPSDHPIIIKGAHAMSSVNSVIWL-NETTIVSAGQDSNI 604 LA GS D++V +W + ++ + ++ + V V W + + + +D ++ Sbjct: 72 LLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSV 131 Query: 605 KFWNVP 610 W Sbjct: 132 WIWETD 137 >4YCZ-A nrPDB Length = 876 Score = 133 bits (335), Expect = 2e-31, Method: Composition-based stats. Identities = 46/282 (16%), Positives = 88/282 (31%), Gaps = 36/282 (12%) Query: 29 AGDKIQYCNGTS---VYTVPVGSLTDTEIYTEHSHQTTVAKTSPS--GYYCASGDVHGNV 83 G ++ C+ ++ + + TE H + G AS G V Sbjct: 29 YGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKV 88 Query: 84 RIWDTTQTTHILKTTIPVFSGPVKDISWDSE--SKRIAAVGEGRERFGHVFLFDTGTSNG 141 IW + V +SW +A F ++ + Sbjct: 89 LIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHS- 147 Query: 142 NLTGQARAMNSVDFKP----------------SRPFRIISGSDDNTVAIFEGPP----FK 181 +NSV + P + R ++G DN + I+ P +K Sbjct: 148 IFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYK 207 Query: 182 FKST-FGEHTKFVHSVRYNP---DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 + HT +V V ++P S AS D T+ ++ + K + Sbjct: 208 LEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANPLQW----NCKVLN 263 Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPV 279 +V+ ++WS G +A++ D + +W + + Sbjct: 264 FDAAVWRVSWSLSGNVLAASGGDNKVTLWKENLKGEWECVKT 305 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 52/280 (18%), Positives = 94/280 (33%), Gaps = 28/280 (10%) Query: 56 TEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS-- 113 + H A G A+ ++I++ T L T+ G V +SW Sbjct: 15 SGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPK 74 Query: 114 ESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKP-SRPFRIISGSDDNTV 172 +A+ G + L + ++N V + P + S D V Sbjct: 75 YGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNV 134 Query: 173 AIFEGPPFKFKST-FGEHTKFVHSVRYNPDGS-----------------LFASTGGDGTI 214 ++ E ++ + F H V+SV + P S F + G D + Sbjct: 135 SVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNAL 194 Query: 215 VLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD---GTKIASASADKTIKIW--NVA 269 ++ T T E + L H+ V + WSP + IASAS D+T++IW + A Sbjct: 195 KIWAYDPATNTYKLEREPL--TGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPA 252 Query: 270 TLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFV 309 + ++ + L + + + Sbjct: 253 NPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLW 292 Score = 109 bits (271), Expect = 4e-24, Method: Composition-based stats. Identities = 50/308 (16%), Positives = 94/308 (30%), Gaps = 29/308 (9%) Query: 278 PVGTRIEDQQLGIIWTKQALVSISANGFINF--VNPELGSIDQVRYGHNKAITALSSS-- 333 G + + + L + S++ I + E + + GH+ A+ +S + Sbjct: 14 NSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHP 73 Query: 334 ADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVV 393 G L SA +G + W G R+F + + S + + + Sbjct: 74 KYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCL-------LA 126 Query: 394 PAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSC 453 A G S + + A S G + S+ Sbjct: 127 CASSDGNVSVLEFRDNSWEHSIFHAHGLG-----VNSVSWAPATSPGSIVSSKPGPKST- 180 Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKT----IVHPAEITSVAFSNN---GAFL 506 + GG D+ + ++ A+ + H + VA+S +++ Sbjct: 181 -----GNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYI 235 Query: 507 VATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMN 566 + + R V ++ L A V VSWS LA DN V +W N Sbjct: 236 ASASEDRTVRIWTSDPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLWKEN 295 Query: 567 KPSDHPII 574 + + Sbjct: 296 LKGEWECV 303 Score = 96.9 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 53/314 (16%), Positives = 107/314 (34%), Gaps = 33/314 (10%) Query: 231 DSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGI 290 + N H + G ++A+ S+D+TIKI+ + + ++ + + Sbjct: 10 QVIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIE-GETQRLTETLKGHDGAVWCV 68 Query: 291 IWT----KQALVSISANGFINFVNPELGSIDQVRYG--HNKAITALSSSAD--GKTLFSA 342 W L S +G + G+ ++ H ++ +S S G L A Sbjct: 69 SWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACA 128 Query: 343 DAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDS 402 ++G+++ + H + +VSW PA G Sbjct: 129 SSDGNVSVLEFRDNSWEHSIFHAHGLGVN-----------SVSWA------PATSPGSIV 171 Query: 403 SKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSND--- 459 S K + + +D + + A Y + + VA S Sbjct: 172 SSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQ 231 Query: 460 KQFVAVGGQDSKVHVYKLSGASVSE--VKTIVHPAEITSVAFSNNGAFLVATDQSRKVIP 517 K ++A +D V ++ A+ + K + A + V++S +G L A+ KV Sbjct: 232 KSYIASASEDRTVRIWTSDPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTL 291 Query: 518 Y--SVANNFELAHT 529 + ++ +E T Sbjct: 292 WKENLKGEWECVKT 305 Score = 84.9 bits (208), Expect = 9e-17, Method: Composition-based stats. Identities = 41/213 (19%), Positives = 77/213 (36%), Gaps = 36/213 (16%) Query: 429 ACYKHIAIYS----HGKLTEVPISYNSS--CVALSND--KQFVAVGGQDSKVHVYKLSGA 480 + + I I+ +LTE ++ + CV+ ++ +A G D KV +++ Sbjct: 37 SSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIWRELNG 96 Query: 481 SVSEVKTIV-HPAEITSVAFSNN--GAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTA 537 + + H A + V++S + G L V +N + H Sbjct: 97 AWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHSI--FHAHGL 154 Query: 538 KVACVSWSP-----------------DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGA-- 578 V VSW+P N R TG DN++ +W + ++ + + Sbjct: 155 GVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLT 214 Query: 579 HAMSSVNSVIWLN----ETTIVSAGQDSNIKFW 607 V V W ++ I SA +D ++ W Sbjct: 215 GHTDWVRDVAWSPTVLQKSYIASASEDRTVRIW 247 Score = 49.5 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 16/77 (20%), Positives = 27/77 (35%), Gaps = 4/77 (5%) Query: 534 FHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNET 593 H + RLAT S D ++ ++ + + H +V V W + Sbjct: 16 GHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHD-GAVWCVSWAHPK 74 Query: 594 T---IVSAGQDSNIKFW 607 + SAG D + W Sbjct: 75 YGNILASAGYDGKVLIW 91 >3JRO-A nrPDB Length = 753 Score = 132 bits (331), Expect = 5e-31, Method: Composition-based stats. Identities = 48/264 (18%), Positives = 88/264 (33%), Gaps = 28/264 (10%) Query: 29 AGDKIQYCNGTS---VYTVPVGSLTDTEIYTEHSHQTTVAKTSPS--GYYCASGDVHGNV 83 G ++ C+ ++ V + + T H + G AS G V Sbjct: 20 YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKV 79 Query: 84 RIWDTTQTTHILKTTIPVFSGPVKDISW--DSESKRIAAVGEGRERFGHVFLFDTGTSNG 141 IW V S V + W + + F + TS Sbjct: 80 LIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI 139 Query: 142 NLTGQARAMNSVDFKPS------------RPFRIISGSDDNTVAIF----EGPPFKFKST 185 + A +NS + P+ + ++G DN V I+ + + +ST Sbjct: 140 IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLEST 199 Query: 186 FGEHTKFVHSVRYNPD---GSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSV 242 H+ +V V ++P S AS D T +++ + G ++ LK + Sbjct: 200 LEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW--TQDNEQGPWKKTLLKEEKFPDVL 257 Query: 243 FGLTWSPDGTKIASASADKTIKIW 266 + +WS G +A + D + +W Sbjct: 258 WRASWSLSGNVLALSGGDNKVTLW 281 Score = 119 bits (299), Expect = 3e-27, Method: Composition-based stats. Identities = 53/283 (18%), Positives = 96/283 (33%), Gaps = 32/283 (11%) Query: 54 IYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS 113 I H+ A G A+ ++I++ TH L T+ GPV + W Sbjct: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 Query: 114 E--SKRIAAVGEGRERFGHVFLFDTG--TSNGNLTGQARAMNSVDFKP-SRPFRIISGSD 168 +A+ + ++ + G + + ++NSV + P ++ S Sbjct: 64 PKFGTILASCSYDGKVL--IWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 Query: 169 DNTVAI--FEGPPFKFKSTFGEHTKFVHSVRYNP-----DGSL--------FASTGGDGT 213 D V++ F+ H V+S + P DG F + G D Sbjct: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 Query: 214 IVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD---GTKIASASADKTIKIW--NV 268 + ++ +T V E HS V + WSP + +AS S D+T IW + Sbjct: 182 VKIWKYNSDAQTYVLE---STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDN 238 Query: 269 ATLKVEKTIPVGTRIEDQ--QLGIIWTKQALVSISANGFINFV 309 +KT+ + D + + L + + Sbjct: 239 EQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 101 bits (252), Expect = 6e-22, Method: Composition-based stats. Identities = 50/312 (16%), Positives = 91/312 (29%), Gaps = 39/312 (12%) Query: 274 EKTIPVGTRIEDQQLGIIWTKQALVSISANGFINF--VNPELGSIDQVRYGHNKAITALS 331 I + + + L + S++ I V E + GH + + Sbjct: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 Query: 332 SS--ADGKTLFSADAEGHINSWDISTGISNRV-FPDVHATMITGIKTTSK--GDLFTVSW 386 + G L S +G + W G +++ VH+ + ++ G L V+ Sbjct: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 Query: 387 DDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVP 446 D V + +G + H + Sbjct: 121 SDGKVSV-----------------------VEFKENGTTSPIIIDAHAIGVNSASWAPAT 157 Query: 447 ISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKT---IVHPAEITSVAFSNN- 502 I + ++FV GG D+ V ++K + + + V H + VA+S Sbjct: 158 IEEDGEHNGTKESRKFV-TGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV 216 Query: 503 --GAFLVATDQSRKVIPY--SVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDN 558 ++L + Q R I + + SWS LA DN Sbjct: 217 LLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDN 276 Query: 559 SVIVWNMNKPSD 570 V +W N Sbjct: 277 KVTLWKENLEGK 288 Score = 89.5 bits (220), Expect = 4e-18, Method: Composition-based stats. Identities = 51/331 (15%), Positives = 96/331 (29%), Gaps = 67/331 (20%) Query: 188 EHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW 247 H + +H + G A+ D TI ++ T + H G V+ + W Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLI-----DTLTGHEGPVWRVDW 61 Query: 248 -SPD-GTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQ----ALVSIS 301 P GT +AS S D + IW + I V + W L+ S Sbjct: 62 AHPKFGTILASCSYDGKVLIWKEENGR-WSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 Query: 302 ANGFINFVNPELGSIDQ--VRYGHNKAITALSSSA-----DG--------KTLFSADAEG 346 ++G ++ V + + H + + S + DG + + A+ Sbjct: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 Query: 347 HINSWDISTGISNRVF---PDVHATMITGIKTTSK---GDLFTVSWDDHLKVVPAGGSGV 400 + W ++ V + H+ + + + D ++ + Sbjct: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 Query: 401 DSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDK 460 K K P L ++ S Sbjct: 241 GPWKKTLLKEEKFPDVLWRAS----------------------------------WSLSG 266 Query: 461 QFVAVGGQDSKVHVYKLSGASVSEVKTIVHP 491 +A+ G D+KV ++K + E VH Sbjct: 267 NVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 Score = 81.8 bits (200), Expect = 7e-16, Method: Composition-based stats. Identities = 37/168 (22%), Positives = 59/168 (35%), Gaps = 21/168 (12%) Query: 460 KQFVAVGGQDSKVHVYKLSGASVSEVKT-IVHPAEITSVAF-SNN-GAFLVATDQSRKVI 516 + +A D + ++++ G + + T H + V + G L + KV+ Sbjct: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 Query: 517 PYSVANNFELAHTNSWTFHTAKVACVSWSPD--NVRLATGSLDNSVIVWNMNKPSDHPII 574 + N + H+A V V W+P L S D V V + I Sbjct: 81 IWKEENG-RWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI 139 Query: 575 IKGAHAMSSVNSVIWLNETT--------------IVSAGQDSNIKFWN 608 I AHA+ VNS W T V+ G D+ +K W Sbjct: 140 IIDAHAI-GVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 Score = 77.6 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 35/169 (20%), Positives = 56/169 (33%), Gaps = 22/169 (13%) Query: 460 KQFVAVGGQDSKVHVYKLSGASVSEVKT-IVHPAEITSVAFSNN--GAFLVATDQSRKVI 516 +A D KV ++K S++ VH A + SV ++ + G L+ KV Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 517 PYSVANNFELAHTNSWTFHTAKVACVSWSP-------------DNVRLATGSLDNSVIVW 563 N + H V SW+P ++ + TG DN V +W Sbjct: 127 VVEFKENGTTS-PIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 Query: 564 NMNKPSDHPII-IKGAHAMSSVNSVIWLNE----TTIVSAGQDSNIKFW 607 N + ++ V V W + + S QD W Sbjct: 186 KYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 Score = 44.1 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 16/79 (20%), Positives = 27/79 (34%), Gaps = 4/79 (5%) Query: 533 TFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNE 592 H + RLAT S D ++ ++ + + H +I V V W + Sbjct: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGET-HKLIDTLTGHEGPVWRVDWAHP 64 Query: 593 ---TTIVSAGQDSNIKFWN 608 T + S D + W Sbjct: 65 KFGTILASCSYDGKVLIWK 83 >4XYI-A nrPDB Length = 430 Score = 131 bits (330), Expect = 7e-31, Method: Composition-based stats. Identities = 42/247 (17%), Positives = 96/247 (38%), Gaps = 29/247 (11%) Query: 45 PVGSLTDTEIYTEHSHQTTVAKTS--PSGYYCASGDVHGNVRIWDTTQTTHILKTTIPV- 101 P+ H+ + + G A+G ++ +WD + L+ +I V Sbjct: 168 PIVQTGHQACLRHHTSEGFGLGWNFIQEGT-LATGTEDTSICVWDIKGKSLSLEKSIDVA 226 Query: 102 -------FSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTG-----TSNGNLTGQARA 149 + V D+ + + + + + + DT +++ + + Sbjct: 227 PVSVYHRHTAVVNDLQFHLQHEALLTSVSD---DCTLQIHDTRLPSSSSASQCVKAHEQP 283 Query: 150 MNSVDFKPSRPFRIISGSDDNTVAIFEGPP-FKFKSTFGEHTKFVHSVRYNP-DGSLFAS 207 +N V F P + + + S D+TVA+++ + T H V++V+++P D + + Sbjct: 284 VNGVAFNPFNDYLLATASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVT 343 Query: 208 TGGDGTIVLYNGVDGTKTGVFEDDSLKNV-------AHSGSVFGLTWSPDGTK-IASASA 259 + D + +++ + ED H+ V L+W+P+ +AS + Sbjct: 344 SSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLAD 403 Query: 260 DKTIKIW 266 D ++IW Sbjct: 404 DNILQIW 410 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 48/293 (16%), Positives = 106/293 (36%), Gaps = 45/293 (15%) Query: 101 VFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGN--------LTGQARAMNS 152 G V + ++ I A G G++F + L Sbjct: 129 HHEGDVNKARFMPQNPDIIAT-LGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFG 187 Query: 153 VDFKPSRPFRIISGSDDNTVAIFEGPPFKF----------KSTFGEHTKFVHSVRYN-PD 201 + + + + +G++D ++ +++ S + HT V+ ++++ Sbjct: 188 LGWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQH 247 Query: 202 GSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP-DGTKIASASAD 260 +L S D T+ +++ T+ S AH V G+ ++P + +A+ASAD Sbjct: 248 EALLTSVSDDCTLQIHD----TRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASAD 303 Query: 261 KTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQ---ALVSISANGFINFVNPELGSID 317 T+ +W++ ++ + + ED+ + W+ LV+ S + + + + Sbjct: 304 HTVALWDLR--RLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEE 361 Query: 318 QV--------------RYGHNKAITALSSSADGKT-LFSADAEGHINSWDIST 355 Q GH ++ LS + + K L S + + W S Sbjct: 362 QTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSK 414 Score = 101 bits (250), Expect = 1e-21, Method: Composition-based stats. Identities = 41/312 (13%), Positives = 93/312 (29%), Gaps = 32/312 (10%) Query: 135 DTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKST--------F 186 D G +N F P P I + + IF+ ++ + Sbjct: 119 DYGLDIVQKIHHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACL 178 Query: 187 GEHTKFVHSVRYN-PDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA---HSGSV 242 HT + +N A+ D +I +++ + + D H+ V Sbjct: 179 RHHTSEGFGLGWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVV 238 Query: 243 FGLTWS-PDGTKIASASADKTIKIWNV---ATLKVEKTIPVGTRIEDQQLGIIWTKQALV 298 L + + S S D T++I + ++ + + + + + L Sbjct: 239 NDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLA 298 Query: 299 SISANGFINFVNPEL-GSIDQVRYGHNKAITALSSSA-DGKTLFSADAEGHINSWDISTG 356 + SA+ + + GH + + S D L ++ + + WD+S Sbjct: 299 TASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKI 358 Query: 357 ISNRVFPD-------------VHATMITGIKTTSKGDLFTVSW-DDHLKVVPAGGSGVDS 402 + D H ++ + S DD++ + + + + Sbjct: 359 GEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSKVIWA 418 Query: 403 SKAVANKLSSQP 414 S ++ Sbjct: 419 SDSLKIDSKDLE 430 Score = 81.5 bits (199), Expect = 1e-15, Method: Composition-based stats. Identities = 40/209 (19%), Positives = 80/209 (38%), Gaps = 19/209 (9%) Query: 417 LAVSADGDIAVAACYKHIAIYSHG---KLTEVPISYNSSCVALSNDKQFVAVGGQDSKVH 473 L ++ +G I Y+ I G L + +A G +D+ + Sbjct: 150 LGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLGWNFIQEGT-LATGTEDTSIC 208 Query: 474 VYKLSGASVSEVKTI---------VHPAEITSVAFS-NNGAFLVATDQSRKVIPYSVANN 523 V+ + G S+S K+I H A + + F + A L + + + Sbjct: 209 VWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTSVSDDCTLQIHDTRLP 268 Query: 524 FELAHTNSWTFHTAKVACVSWSPDNVRL-ATGSLDNSVIVWNMNKPSDHPIIIKGAHAMS 582 + + H V V+++P N L AT S D++V +W++ + + + Sbjct: 269 SSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRR--LNQRLHTLEGHED 326 Query: 583 SVNSVIWL--NETTIVSAGQDSNIKFWNV 609 V +V W +E +V++ D + W++ Sbjct: 327 EVYNVQWSPHDEPILVTSSTDRRVCVWDL 355 Score = 79.5 bits (194), Expect = 4e-15, Method: Composition-based stats. Identities = 53/355 (14%), Positives = 105/355 (29%), Gaps = 77/355 (21%) Query: 226 GVFEDDSLKNVAHSGSVFGLTWSPDGT-KIASASADKTIKIWNVATLKVEKTIPVGTRIE 284 G + D ++ + H G V + P IA+ + I+++ + + + G + Sbjct: 118 GDYGLDIVQKIHHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQ-- 175 Query: 285 DQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSA-DGKTLFSAD 343 H L + TL + Sbjct: 176 ---------------------------------ACLRHHTSEGFGLGWNFIQEGTLATGT 202 Query: 344 AEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSS 403 + I WDI G ++ + V Sbjct: 203 EDTSICVWDIK------------------------GKSLSLEKSIDVAPVSVYHRHTAVV 238 Query: 404 KAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFV 463 + L + L +VS D + + + S + VA + ++ Sbjct: 239 NDLQFHLQHEALLTSVSDDCTLQIHDTR--LPSSSSASQCVKAHEQPVNGVAFNPFNDYL 296 Query: 464 -AVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSN-NGAFLVATDQSRKVIPYSVA 521 A D V ++ L + H E+ +V +S + LV + R+V + ++ Sbjct: 297 LATASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLS 356 Query: 522 NNFELAHTNSWT-----------FHTAKVACVSWSPDNVR-LATGSLDNSVIVWN 564 E HT +V+ +SW+P+N LA+ + DN + +W+ Sbjct: 357 KIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWS 411 >6CHG-A nrPDB Length = 312 Score = 126 bits (316), Expect = 3e-29, Method: Composition-based stats. Identities = 54/297 (18%), Positives = 104/297 (35%), Gaps = 17/297 (5%) Query: 27 TPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIW 86 +P G+ I C T + + S ++ T H SP ASG V I Sbjct: 22 SPDGELIAICQNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSKCIASGSEDFTVEI- 80 Query: 87 DTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQ 146 T + + + PV I ++++ + + + + +GT+ ++ Sbjct: 81 --THIIYGRIRRLMGHTAPVISICYNNKGNILCSSS--MDESIKEWHVLSGTALKTMSAH 136 Query: 147 ARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKF--------VHSVRY 198 + A+ S+D + SGS D + IF+ T + + +V++ Sbjct: 137 SDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTVKF 196 Query: 199 NPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLT-WSPDGT--KIA 255 + +G D + L+ GT F + A GL P G + Sbjct: 197 SRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLELIYPQGKDPLVI 256 Query: 256 SASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPE 312 S + ++ +WNV + + + I R + I + + ++S NG N Sbjct: 257 SGNDSGSMCVWNVYSKNLVQKIDEKHR-NSPLISISASYDKVATLSLNGECNLFRVH 312 Score = 117 bits (293), Expect = 1e-26, Method: Composition-based stats. Identities = 44/240 (18%), Positives = 86/240 (35%), Gaps = 18/240 (7%) Query: 151 NSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGG 210 S P +I+ + + ++E K H + ++ + ++PD AS Sbjct: 17 TSCQISPDG--ELIAICQNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSKCIASGSE 74 Query: 211 DGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT 270 D T+ + T + + + H+ V + ++ G + S+S D++IK W+V + Sbjct: 75 DFTVEI--------THIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLS 126 Query: 271 LKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKA---- 326 KT+ + + L S S +G I + E G + Sbjct: 127 GTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAED 186 Query: 327 ----ITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLF 382 I+ + S +GK L + + W+ + G R F H +K +L Sbjct: 187 GVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLELI 246 Score = 91.1 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 27/158 (17%), Positives = 69/158 (43%), Gaps = 7/158 (4%) Query: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATD 510 S+ +S D + +A+ Q++ + VY++S + + ++ T H I + +S + + + Sbjct: 16 STSCQISPDGELIAIC-QNTDMLVYEISSSKMMKL-TTTHKECINCLCWSPDSKCIASGS 73 Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 + V + HTA V + ++ L + S+D S+ W++ + Sbjct: 74 EDFTVEI----THIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTA 129 Query: 571 HPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 + + A+ S++ + + + + S D I+ ++ Sbjct: 130 LKTMSAHSDAVVSIDIPKF-DSSILSSGSYDGLIRIFD 166 Score = 90.7 bits (223), Expect = 2e-18, Method: Composition-based stats. Identities = 43/314 (13%), Positives = 99/314 (31%), Gaps = 44/314 (14%) Query: 243 FGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISA 302 SPDG IA + ++ +++ K+ K + + L + + S S Sbjct: 17 TSCQISPDGELIAICQNTDML-VYEISSSKMMK-LTTTHKECINCLCWSPDSKCIASGSE 74 Query: 303 NGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVF 362 + + + G I + GH + ++ + G L S+ + I W + +G + + Sbjct: 75 DFTVEITHIIYGRI-RRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTALKTM 133 Query: 363 PDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSAD 422 H+ + I S + K + ++ D Sbjct: 134 -SAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKD------WIAED 186 Query: 423 GDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASV 482 G + + S V S + +F+ V D+ V +++ + +V Sbjct: 187 GVVPI------------------------STVKFSRNGKFLLVKSLDNVVKLWEYTRGTV 222 Query: 483 SEVKTIVHPAEITSVAFS-------NNGA--FLVATDQSRKVIPYSVANNFELAHTNSWT 533 H + ++ G +++ + S + ++V + L Sbjct: 223 VRTFLWPHQETKAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSK-NLVQKIDEK 281 Query: 534 FHTAKVACVSWSPD 547 + + +S S D Sbjct: 282 HRNSPLISISASYD 295 Score = 74.9 bits (182), Expect = 1e-13, Method: Composition-based stats. Identities = 47/265 (17%), Positives = 90/265 (33%), Gaps = 33/265 (12%) Query: 24 LGNTPAGDKIQYCNGTSVYTVPVGSLTDTEI--YTEHSHQTTVAKTSPSGYYCASGDVHG 81 L +P I G+ +TV + + I H+ + G S + Sbjct: 60 LCWSPDSKCIAS--GSEDFTVEITHIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDE 117 Query: 82 NVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNG 141 +++ W T + T+ S V I I + G + +F ++G Sbjct: 118 SIKEWHVLSGTAL--KTMSAHSDAVVSIDIPKFDSSILSSGS-YDGLIRIFDTESGHCLK 174 Query: 142 NLTGQARA--------MNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFV 193 LT +++V F + F ++ S DN V ++E TF + Sbjct: 175 TLTYDKDWIAEDGVVPISTVKFSRNGKFLLVK-SLDNVVKLWEYTRGTVVRTFLWPHQET 233 Query: 194 HS-VRYN-------PDGS--LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVF 243 + ++YN P G L S G++ ++N ++ H S Sbjct: 234 KAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEK------HRNSPL 287 Query: 244 GLTWSPDGTKIASASADKTIKIWNV 268 ++ S K+A+ S + ++ V Sbjct: 288 -ISISASYDKVATLSLNGECNLFRV 311 Score = 71.1 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 29/257 (11%), Positives = 74/257 (28%), Gaps = 22/257 (8%) Query: 371 TGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAAC 430 T + + G+L + + + V S + L S D + Sbjct: 17 TSCQISPDGELIAICQNTDMLVYEISSS---KMMKLTTTHKECINCLCWSPDSKCIASGS 73 Query: 431 YKHIAIYSH---GKLTEV-PISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVK 486 +H G++ + + + +N + D + + + + + Sbjct: 74 EDFTVEITHIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTALKTM 133 Query: 487 TIVHPAEITSVAFSN-NGAFLVATDQSRKVIPYSVANNFELAHTN-----SWTFHTAKVA 540 + H + S+ + + L + + + + L ++ Sbjct: 134 S-AHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPIS 192 Query: 541 CVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPI-IIKGAHAMSSVNS-------VIWLNE 592 V +S + L SLDN V +W + + + + + + Sbjct: 193 TVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLELIYPQGKD 252 Query: 593 TTIVSAGQDSNIKFWNV 609 ++S ++ WNV Sbjct: 253 PLVISGNDSGSMCVWNV 269 >5OV3-A nrPDB Length = 381 Score = 125 bits (314), Expect = 5e-29, Method: Composition-based stats. Identities = 64/308 (20%), Positives = 121/308 (39%), Gaps = 42/308 (13%) Query: 195 SVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKI 254 + +N G+L A DG IV+++ + + AH V L WS DG K+ Sbjct: 30 TCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIIS-------AHIHPVCSLCWSRDGHKL 82 Query: 255 ASASADKTIKIWNVATLKVEKTIPVGTRI--------EDQQLGIIWTKQALVSISANGFI 306 SAS D + W+V + ++ + I + ++ + K A V ++ + Sbjct: 83 VSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSK 142 Query: 307 NFVNP--ELGSIDQVRYGHNKAITALSSSADGKTLF-SADAEGHINSWDISTGISNRVFP 363 + V P + ++ V + + +A GK L D++ + S+ ++TG SN Sbjct: 143 HVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSN---- 198 Query: 364 DVHATMITGIKTTSKGDLFTVSWDDHL-------KVVPAGGSGV-DSSKAVANKLSSQPL 415 T I I+ KG F ++ D + +++ G G + + + + ++ P Sbjct: 199 ---TTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPW 255 Query: 416 -GLAVSADGDIAVAACYKHIAIY----SHGKLTEVPISYNSSC---VALSNDKQFVAVGG 467 S DG+ VA + A+Y S G L ++ VA + +A Sbjct: 256 KKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASIS 315 Query: 468 QDSKVHVY 475 V ++ Sbjct: 316 -SGVVSIW 322 Score = 89.2 bits (219), Expect = 5e-18, Method: Composition-based stats. Identities = 47/300 (15%), Positives = 87/300 (29%), Gaps = 30/300 (10%) Query: 287 QLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEG 346 L +G I + I ++ H + +L S DG L SA + Sbjct: 30 TCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDN 89 Query: 347 HINSWDISTGISNRVF--------PDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGS 398 ++ WD+ +G ++ F H + + K V Sbjct: 90 IVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVD 149 Query: 399 GVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSN 458 VA+ +A G I V + S T + + + Sbjct: 150 DDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFAR 209 Query: 459 DKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSV------------AFSNNGAFL 506 + D + VY G + P + + FS +G ++ Sbjct: 210 KGSCFLINTADRIIRVYD--GREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYI 267 Query: 507 VATD-QSRKVIPY--SVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVW 563 VA + + + S+ N ++ H + V+W P +A+ S V +W Sbjct: 268 VAGSARQHALYIWEKSIGNLVKILHGT----RGELLLDVAWHPVRPIIASISS-GVVSIW 322 Score = 86.1 bits (211), Expect = 5e-17, Method: Composition-based stats. Identities = 45/296 (15%), Positives = 91/296 (30%), Gaps = 16/296 (5%) Query: 25 GNTPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNV 83 G + + + +I + H H S G+ S V Sbjct: 32 TFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIV 91 Query: 84 RIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNL 143 WD + F P+ + + + V + + L D+ Sbjct: 92 SQWDVLSGDCDQR---FRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDS-KHVVLP 147 Query: 144 TGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFG-----EHTKFVHSVRY 198 +N V R I +G+ + + + ++F +T + S+ + Sbjct: 148 VDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEF 207 Query: 199 NPDGSLFASTGGDGTIVLYNGVD----GTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKI 254 GS F D I +Y+G + G L+++ + +S DG I Sbjct: 208 ARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYI 267 Query: 255 ASASADKT-IKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFV 309 + SA + + IW + + K + + + + SIS+ G ++ Sbjct: 268 VAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISS-GVVSIW 322 Score = 70.7 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 38/299 (12%), Positives = 82/299 (27%), Gaps = 24/299 (8%) Query: 328 TALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWD 387 + + G L +G I WD T ++ H + + + G + Sbjct: 29 LTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKII-SAHIHPVCSLCWSRDGHKLVSAST 87 Query: 388 DHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPI 447 D++ SG D + + + V + + V + Sbjct: 88 DNIVSQWDVLSG-DCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVL 146 Query: 448 SYNSSC-----VALSNDKQFVAVGGQDSKVHVYKLSGASVS----EVKTIVHPAEITSVA 498 + + +++ G K+ V K + + I S+ Sbjct: 147 PVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIE 206 Query: 499 FSNNGAFLVATDQSRKVIPYSVANNF---------ELAHTNSWTFHTAKVACVSWSPDNV 549 F+ G+ + R + Y + T C +S D Sbjct: 207 FARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKC-CFSGDGE 265 Query: 550 RLATGS-LDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFW 607 + GS +++ +W K + + I + V W I+++ + W Sbjct: 266 YIVAGSARQHALYIWE--KSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIW 322 Score = 51.8 bits (122), Expect = 9e-07, Method: Composition-based stats. Identities = 15/94 (15%), Positives = 36/94 (38%), Gaps = 7/94 (7%) Query: 436 IYSHGKLTEVPISYNSSCV------ALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV 489 + S G+ C+ + +AVG D ++ ++ ++++ + Sbjct: 7 LESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIIS-A 65 Query: 490 HPAEITSVAFSNNGAFLVATDQSRKVIPYSVANN 523 H + S+ +S +G LV+ V + V + Sbjct: 66 HIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSG 99 >3ODT-A nrPDB Length = 313 Score = 124 bits (312), Expect = 9e-29, Method: Composition-based stats. Identities = 55/283 (19%), Positives = 100/283 (35%), Gaps = 25/283 (8%) Query: 74 CASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFG-HVF 132 AS G VR+W ++ L T + G + + +DSE + + G+ G +F Sbjct: 32 VASVSRDGTVRLW--SKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDTMINGVPLF 89 Query: 133 LFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKF 192 L G + S+ F + +ISGS D T ++ H Sbjct: 90 ATSGEDPLYTLIGHQGNVCSLSF---QDGVVISGSWDKTAKVW--KEGSLVYNLQAHNAS 144 Query: 193 VHS---VRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP 249 V V ++ + F + D TI L+ + F V H V Sbjct: 145 VWDAKVVSFSEN--KFLTASADKTIKLW--QNDKVIKTFSGIHNDVVRHLAVV------- 193 Query: 250 DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFV 309 D S S D IK+ ++ T V +T + ++ +VS + + Sbjct: 194 DDGHFISCSNDGLIKLVDMHTGDVLRTYEGHESF-VYCIKLLPNGD-IVSCGEDRTVRIW 251 Query: 310 NPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 + E GS+ QV +I ++ ++G + ++ + + Sbjct: 252 SKENGSLKQVITLPAISIWSVDCMSNGDIIV-GSSDNLVRIFS 293 Score = 116 bits (289), Expect = 4e-26, Method: Composition-based stats. Identities = 72/323 (22%), Positives = 123/323 (38%), Gaps = 26/323 (8%) Query: 95 LKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVD 154 L T+ V+D+ +SK + +G R D TGQ +NSV Sbjct: 10 LSATLKGHDQDVRDVVAVDDSKVASVSRDGTVRLWSKD--DQWLGTVVYTGQ-GFLNSVC 66 Query: 155 FKPSRPFRIISGSDD--NTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDG 212 + + + G D N V +F T H V S+ + + S D Sbjct: 67 YDSEKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSF--QDGVVISGSWDK 124 Query: 213 TIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFG---LTWSPDGTKIASASADKTIKIWNVA 269 T ++ +G+ + AH+ SV+ +++S + K +ASADKTIK+W Sbjct: 125 TAKVW--KEGSLVYNLQ-------AHNASVWDAKVVSFSEN--KFLTASADKTIKLW--Q 171 Query: 270 TLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITA 329 KV KT + L ++ +S S +G I V+ G + + GH + Sbjct: 172 NDKVIKTFSGIHNDVVRHLAVVDDGH-FISCSNDGLIKLVDMHTGDVLRTYEGHESFVYC 230 Query: 330 LSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDH 389 + +G + S + + W G +V + A I + S GD+ S D+ Sbjct: 231 IKLLPNGD-IVSCGEDRTVRIWSKENGSLKQVIT-LPAISIWSVDCMSNGDIIVGSSDNL 288 Query: 390 LKVVPAGGSGVDSSKAVANKLSS 412 +++ S S + +L S Sbjct: 289 VRIFSQEKSRWASEDEIKGELRS 311 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 41/224 (18%), Positives = 83/224 (37%), Gaps = 25/224 (11%) Query: 47 GSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPV 106 + + +YT HQ V S SG ++W L + + V Sbjct: 90 ATSGEDPLYTLIGHQGNVCSLSFQDGVVISGSWDKTAKVW----KEGSLVYNLQAHNASV 145 Query: 107 KD---ISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTG-QARAMNSVDFKPSRPFR 162 D +S+ SE+K + A + + L+ +G + + Sbjct: 146 WDAKVVSF-SENKFLTASADKT-----IKLWQNDKVIKTFSGIHNDVVRHLAVVDDG--H 197 Query: 163 IISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDG 222 IS S+D + + + T+ H FV+ ++ P+G S G D T+ +++ +G Sbjct: 198 FISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIWSKENG 256 Query: 223 TKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIW 266 + V ++ S++ + +G I S+D ++I+ Sbjct: 257 SLKQVITLPAI-------SIWSVDCMSNGDIIV-GSSDNLVRIF 292 Score = 89.9 bits (221), Expect = 3e-18, Method: Composition-based stats. Identities = 42/303 (13%), Positives = 106/303 (34%), Gaps = 18/303 (5%) Query: 309 VNPELG-SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHA 367 ++P G + GH++ + + + D K + S +G + W Sbjct: 2 IDPFTGYQLSATLKGHDQDVRDVVAVDDSK-VASVSRDGTVRLWS-KDDQWLGTVVYTGQ 59 Query: 368 TMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVS-ADGDIA 426 + + S+ +L D + + + + Q ++S DG + Sbjct: 60 GFLNSVCYDSEKELLLFGGKDTM-INGVPLFATSGEDPLYTLIGHQGNVCSLSFQDGVVI 118 Query: 427 VAACYKHIAIYSHGKLTEVPISYNS---SCVALSNDKQFVAVGGQDSKVHVYKLSGASVS 483 + K ++ G L ++N+ +S + D + ++ V Sbjct: 119 SGSWDKTAKVWKEGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLW--QNDKVI 176 Query: 484 EVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVS 543 + + +H + +A ++G F+ + + + L ++ H + V C+ Sbjct: 177 KTFSGIHNDVVRHLAVVDDGHFI-SCSNDGLIKLVDMHTGDVL---RTYEGHESFVYCIK 232 Query: 544 WSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSN 603 P+ + + D +V +W+ S +I A ++ SV+ ++ I+ D+ Sbjct: 233 LLPNGD-IVSCGEDRTVRIWSKENGSLKQVITLPAISIWSVDC---MSNGDIIVGSSDNL 288 Query: 604 IKF 606 ++ Sbjct: 289 VRI 291 Score = 79.5 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 52/281 (18%), Positives = 90/281 (32%), Gaps = 22/281 (7%) Query: 252 TKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFIN---F 308 +K+AS S D T+++W+ + + G + K+ L+ + IN Sbjct: 30 SKVASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCY-DSEKELLLFGGKDTMINGVPL 88 Query: 309 VNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHAT 368 GH + +LS DG + S + W S H Sbjct: 89 FATSGEDPLYTLIGHQGNVCSLSF-QDG-VVISGSWDKTAKVW---KEGSLVYNLQAHNA 143 Query: 369 MITGIKTTS--KGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIA 426 + K S + T S D +K+ K + + LAV DG Sbjct: 144 SVWDAKVVSFSENKFLTASADKTIKLW----QNDKVIKTFSGIHNDVVRHLAVVDDGHFI 199 Query: 427 VAACYKHIAIYSHGK----LTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASV 482 + I + T C+ L + + G+D V ++ S+ Sbjct: 200 SCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIWSKENGSL 258 Query: 483 SEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANN 523 +V T+ + I SV +NG +V V +S + Sbjct: 259 KQVITLPAIS-IWSVDCMSNGDIIV-GSSDNLVRIFSQEKS 297 Score = 41.8 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 14/106 (13%), Positives = 32/106 (30%), Gaps = 10/106 (9%) Query: 506 LVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLD---NSVIV 562 + + + V +S + + + V + + L G D N V + Sbjct: 32 VASVSRDGTVRLWSKDDQW---LGTVVYTGQGFLNSVCYDSEKELLLFGGKDTMINGVPL 88 Query: 563 WNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 + + +I + S+ + ++S D K W Sbjct: 89 FATSGEDPLYTLIGHQGNVCSL----SFQDGVVISGSWDKTAKVWK 130 >2AQ5-A nrPDB Length = 402 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 45/289 (15%), Positives = 99/289 (34%), Gaps = 28/289 (9%) Query: 109 ISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLT---GQARAMNSVDFKPSRPFRIIS 165 + + + + G F + L TG + N+ G + + + P I S Sbjct: 40 CAVNPKFMALICEASGGGAFLVLPLGKTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIAS 99 Query: 166 GSDDNTVAIFEGPPF-------KFKSTFGEHTKFVHSVRYNPD-GSLFASTGGDGTIVLY 217 GS+D TV ++E P + T HTK V V ++P ++ S G D I+++ Sbjct: 100 GSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVW 159 Query: 218 NGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTI 277 + G H +++ + WS DG I ++ DK +++ V Sbjct: 160 DVGTGAAVLTL-----GPDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEK 214 Query: 278 PVGTRIEDQQLGIIWTKQALVSIS----ANGFINFVNPELGSIDQVRY--GHNKAITALS 331 + ++ +++ + + + + + + Sbjct: 215 DRPHEGTRPVHAVFVSEGKILTTGFSRMSERQVALWDTKHLEEPLSLQELDTSSGVLLPF 274 Query: 332 SSADGKTLF-SADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKG 379 D ++ + I ++I++ P +H + K + +G Sbjct: 275 FDPDTNIVYLCGKGDSSIRYFEITSEA-----PFLHYLSMFSSKESQRG 318 Score = 88.8 bits (218), Expect = 6e-18, Method: Composition-based stats. Identities = 38/276 (13%), Positives = 87/276 (31%), Gaps = 23/276 (8%) Query: 57 EHSHQTTVAKTSP-SGYYCASGDVHGNVRIWDTTQTTHIL-----KTTIPVFSGPVKDIS 110 H+ P + ASG V +W+ +L T+ + V ++ Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 111 WDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTG--QARAMNSVDFKPSRPFRIISGSD 168 W ++ + + G + V+ TG + L + SVD+ I + Sbjct: 139 WHPTAQNVL-LSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGAL-ICTSCR 196 Query: 169 DNTVAIFEGPPFKFKSTFGE-HTK--FVHSVRYNPDGSLFASTG---GDGTIVLYNGVDG 222 D V + E + H VH+V + +G + + + + L++ Sbjct: 197 DKRVRVIEPRKGTVVAEKDRPHEGTRPVHAV-FVSEGKILTTGFSRMSERQVALWDTKHL 255 Query: 223 TKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKI-ASASADKTIKIWNVATLKVEKTIPVGT 281 + ++ S V + PD + D +I+ + + + Sbjct: 256 EEPLSLQELDT-----SSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMF 310 Query: 282 RIEDQQLGIIWTKQALVSISANGFINFVNPELGSID 317 ++ Q G+ + + + ++ F + Sbjct: 311 SSKESQRGMGYMPKRGLEVNKCEIARFYKLHERKCE 346 Score = 76.4 bits (186), Expect = 3e-14, Method: Composition-based stats. Identities = 27/166 (16%), Positives = 55/166 (33%), Gaps = 12/166 (7%) Query: 454 VALSN-DKQFVAVGGQDSKVHVYKL-SGASVSEVKTI-----VHPAEITSVAFSNN-GAF 505 +A + +A G +D V V+++ G V ++ H + VA+ Sbjct: 87 IAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNV 146 Query: 506 LVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM 565 L++ ++ + V + T H + V WS D + T D V V Sbjct: 147 LLSAGCDNVILVWDVGTGAAVL-TLGPDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEP 205 Query: 566 NKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSA---GQDSNIKFWN 608 K + + V++V + + + + W+ Sbjct: 206 RKGTVVAEKDRPHEGTRPVHAVFVSEGKILTTGFSRMSERQVALWD 251 Score = 76.4 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 47/238 (19%), Positives = 89/238 (37%), Gaps = 26/238 (10%) Query: 387 DDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAAC--------YKHIAIYS 438 D ++ +V + V + + G S D + V + I Sbjct: 71 DKNVPLVCGHTAPVLDIAWCPHNDNVIASG---SEDCTVMVWEIPDGGLVLPLREPVITL 127 Query: 439 HGKLTEVPISYNSSCVALSND-KQFVAVGGQDSKVHVYKL-SGASVSEVKTIVHPAEITS 496 G V I VA + + G D+ + V+ + +GA+V + VHP I S Sbjct: 128 EGHTKRVGI------VAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYS 181 Query: 497 VAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGS- 555 V +S +GA + + + ++V +A + T V V + + L TG Sbjct: 182 VDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAV-FVSEGKILTTGFS 240 Query: 556 --LDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIV--SAGQDSNIKFWNV 609 + V +W+ + P+ ++ S V + +T IV DS+I+++ + Sbjct: 241 RMSERQVALWDTKHL-EEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEI 297 Score = 71.1 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 27/152 (17%), Positives = 57/152 (37%), Gaps = 11/152 (7%) Query: 464 AVGGQDSKVHVYKLSGASVSEV-KTIVHPAEITSVAFSN-NGAFLVATDQSRKVIPYSVA 521 A GG V +G V H A + +A+ N + + + V+ + + Sbjct: 53 ASGGGAFLVLPLGKTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIP 112 Query: 522 NNFELAHTN----SWTFHTAKVACVSWSPDN-VRLATGSLDNSVIVWNMNKPSDHPIIIK 576 + + + HT +V V+W P L + DN ++VW++ + ++ Sbjct: 113 DGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVG--TGAAVLTL 170 Query: 577 GAH-AMSSVNSVIWLNETTIVSAGQ-DSNIKF 606 G ++ SV W + ++ D ++ Sbjct: 171 GPDVHPDTIYSVDWSRDGALICTSCRDKRVRV 202 Score = 29.8 bits (65), Expect = 3.6, Method: Composition-based stats. Identities = 8/34 (23%), Positives = 14/34 (41%), Gaps = 2/34 (5%) Query: 579 HAMSSVNSVIW--LNETTIVSAGQDSNIKFWNVP 610 + V + W N+ I S +D + W +P Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIP 112 >3JRP-A nrPDB Length = 379 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 48/264 (18%), Positives = 88/264 (33%), Gaps = 28/264 (10%) Query: 29 AGDKIQYCNGTS---VYTVPVGSLTDTEIYTEHSHQTTVAKTSPS--GYYCASGDVHGNV 83 G ++ C+ ++ V + + T H + G AS G V Sbjct: 22 YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKV 81 Query: 84 RIWDTTQTTHILKTTIPVFSGPVKDISW--DSESKRIAAVGEGRERFGHVFLFDTGTSNG 141 IW V S V + W + + F + TS Sbjct: 82 LIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI 141 Query: 142 NLTGQARAMNSVDFKPS------------RPFRIISGSDDNTVAIF----EGPPFKFKST 185 + A +NS + P+ + ++G DN V I+ + + +ST Sbjct: 142 IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLEST 201 Query: 186 FGEHTKFVHSVRYNPD---GSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSV 242 H+ +V V ++P S AS D T +++ + G ++ LK + Sbjct: 202 LEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW--TQDNEQGPWKKTLLKEEKFPDVL 259 Query: 243 FGLTWSPDGTKIASASADKTIKIW 266 + +WS G +A + D + +W Sbjct: 260 WRASWSLSGNVLALSGGDNKVTLW 283 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 53/283 (18%), Positives = 96/283 (33%), Gaps = 32/283 (11%) Query: 54 IYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS 113 I H+ A G A+ ++I++ TH L T+ GPV + W Sbjct: 6 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 65 Query: 114 E--SKRIAAVGEGRERFGHVFLFDTG--TSNGNLTGQARAMNSVDFKP-SRPFRIISGSD 168 +A+ + ++ + G + + ++NSV + P ++ S Sbjct: 66 PKFGTILASCSYDGKVL--IWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 123 Query: 169 DNTVAI--FEGPPFKFKSTFGEHTKFVHSVRYNP-----DGSL--------FASTGGDGT 213 D V++ F+ H V+S + P DG F + G D Sbjct: 124 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 183 Query: 214 IVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD---GTKIASASADKTIKIW--NV 268 + ++ +T V E HS V + WSP + +AS S D+T IW + Sbjct: 184 VKIWKYNSDAQTYVLE---STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDN 240 Query: 269 ATLKVEKTIPVGTRIEDQ--QLGIIWTKQALVSISANGFINFV 309 +KT+ + D + + L + + Sbjct: 241 EQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 283 Score = 83.8 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 47/293 (16%), Positives = 90/293 (30%), Gaps = 39/293 (13%) Query: 314 GSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRV-FPDVHATMITG 372 GS+ + HN+ I GK L + ++ I +++ + H + Sbjct: 1 GSMVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWR 60 Query: 373 IKTTSK--GDLFTVSWDDHLKVVPAGGSGVDSSKAV------------ANKLSSQPLGLA 418 + G + D ++ +G S AV PL L Sbjct: 61 VDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 120 Query: 419 VSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSN-------------DKQFVAV 465 S+DG ++V ++ + + + + + + + + Sbjct: 121 ASSDGKVSVVEFKENG---TTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVT 177 Query: 466 GGQDSKVHVYKLSGASVSEVKT---IVHPAEITSVAFSNN---GAFLVATDQSRKVIPY- 518 GG D+ V ++K + + + V H + VA+S ++L + Q R I + Sbjct: 178 GGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 237 Query: 519 -SVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 + SWS LA DN V +W N Sbjct: 238 QDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGK 290 Score = 81.1 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 51/331 (15%), Positives = 96/331 (29%), Gaps = 67/331 (20%) Query: 188 EHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW 247 H + +H + G A+ D TI ++ T + H G V+ + W Sbjct: 9 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLI-----DTLTGHEGPVWRVDW 63 Query: 248 -SPD-GTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQ----ALVSIS 301 P GT +AS S D + IW + I V + W L+ S Sbjct: 64 AHPKFGTILASCSYDGKVLIWKEENGR-WSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 122 Query: 302 ANGFINFVNPELGSIDQ--VRYGHNKAITALSSSA-----DG--------KTLFSADAEG 346 ++G ++ V + + H + + S + DG + + A+ Sbjct: 123 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 182 Query: 347 HINSWDISTGISNRVF---PDVHATMITGIKTTSK---GDLFTVSWDDHLKVVPAGGSGV 400 + W ++ V + H+ + + + D ++ + Sbjct: 183 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 242 Query: 401 DSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDK 460 K K P L ++ S Sbjct: 243 GPWKKTLLKEEKFPDVLWRAS----------------------------------WSLSG 268 Query: 461 QFVAVGGQDSKVHVYKLSGASVSEVKTIVHP 491 +A+ G D+KV ++K + E VH Sbjct: 269 NVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 299 Score = 76.1 bits (185), Expect = 5e-14, Method: Composition-based stats. Identities = 37/168 (22%), Positives = 59/168 (35%), Gaps = 21/168 (12%) Query: 460 KQFVAVGGQDSKVHVYKLSGASVSEVKT-IVHPAEITSVAF-SNN-GAFLVATDQSRKVI 516 + +A D + ++++ G + + T H + V + G L + KV+ Sbjct: 23 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 82 Query: 517 PYSVANNFELAHTNSWTFHTAKVACVSWSPD--NVRLATGSLDNSVIVWNMNKPSDHPII 574 + N + H+A V V W+P L S D V V + I Sbjct: 83 IWKEENG-RWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI 141 Query: 575 IKGAHAMSSVNSVIWLNETT--------------IVSAGQDSNIKFWN 608 I AHA+ VNS W T V+ G D+ +K W Sbjct: 142 IIDAHAI-GVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 188 Score = 71.8 bits (174), Expect = 7e-13, Method: Composition-based stats. Identities = 35/169 (20%), Positives = 56/169 (33%), Gaps = 22/169 (13%) Query: 460 KQFVAVGGQDSKVHVYKLSGASVSEVKT-IVHPAEITSVAFSNN--GAFLVATDQSRKVI 516 +A D KV ++K S++ VH A + SV ++ + G L+ KV Sbjct: 69 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 128 Query: 517 PYSVANNFELAHTNSWTFHTAKVACVSWSP-------------DNVRLATGSLDNSVIVW 563 N + H V SW+P ++ + TG DN V +W Sbjct: 129 VVEFKENGTTS-PIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 187 Query: 564 NMNKPSDHPII-IKGAHAMSSVNSVIWLNE----TTIVSAGQDSNIKFW 607 N + ++ V V W + + S QD W Sbjct: 188 KYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 236 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 16/79 (20%), Positives = 27/79 (34%), Gaps = 4/79 (5%) Query: 533 TFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNE 592 H + RLAT S D ++ ++ + + H +I V V W + Sbjct: 8 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGET-HKLIDTLTGHEGPVWRVDWAHP 66 Query: 593 ---TTIVSAGQDSNIKFWN 608 T + S D + W Sbjct: 67 KFGTILASCSYDGKVLIWK 85 >4J0W-A nrPDB Length = 343 Score = 123 bits (307), Expect = 3e-28, Method: Composition-based stats. Identities = 66/355 (18%), Positives = 115/355 (32%), Gaps = 40/355 (11%) Query: 183 KSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSL----KNVAH 238 H + + PD S S D +I+ ++ G K V K H Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 66 Query: 239 SGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALV 298 S V + S DG +AS K I IW + + T G R L L Sbjct: 67 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTF-TGHRDAVSGLAFRRGTHQLY 125 Query: 299 SISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGIS 358 S S + + N S + +GH A+ AL + + + + +G + W I Sbjct: 126 STSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIP--EE 183 Query: 359 NRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLA 418 +++ H I I ++ + + + D + + + + A+ L +P Sbjct: 184 SQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEP---- 239 Query: 419 VSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLS 478 + I S L + VA G S V +++ Sbjct: 240 ----------GLEQPFWISSVAALL---------------NTDLVATGSHSSCVRLWQCG 274 Query: 479 GA--SVSEVKTIVHPAEITSVAFSNNGAFLVAT-DQSRKV-IPYSVANNFELAHT 529 + + I I S+ FS++G FLVA Q ++ + + Sbjct: 275 EGFRQLDLLCDIPLVGFINSLKFSSSGDFLVAGVGQEHRLGRWWRIKEARNSVCI 329 Score = 122 bits (306), Expect = 4e-28, Method: Composition-based stats. Identities = 31/175 (17%), Positives = 78/175 (44%), Gaps = 15/175 (8%) Query: 446 PISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEV----------KTIVHPAEIT 495 + +C+ ++ D + +D + + + V K H + + Sbjct: 12 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 71 Query: 496 SVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGS 555 +A S++G +L + D+S+ ++ + + H ++T H V+ +++ +L + S Sbjct: 72 CMAISSDGKYLASGDRSKLILIWEAQS---CQHLYTFTGHRDAVSGLAFRRGTHQLYSTS 128 Query: 556 LDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNVP 610 D SV VWN+ + S + A+++++++ E + + G+D ++ W +P Sbjct: 129 HDRSVKVWNVAENSYVETLFGHQDAVAALDAL--SRECCVTAGGRDGTVRVWKIP 181 Score = 120 bits (301), Expect = 2e-27, Method: Composition-based stats. Identities = 47/334 (14%), Positives = 100/334 (29%), Gaps = 42/334 (12%) Query: 51 DTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHI---------LKTTIPV 101 D + H T +P S ++ W + + P Sbjct: 6 DIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPG 65 Query: 102 FSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPF 161 S V ++ S+ K +A+ R + ++ + TG A++ + F+ Sbjct: 66 HSSHVLCMAISSDGKYLAS--GDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFR-RGTH 122 Query: 162 RIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVD 221 ++ S S D +V ++ + T H V ++ + G DGT+ ++ Sbjct: 123 QLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVW---- 178 Query: 222 GTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGT 281 + E+ L H GS+ + + + S + D ++ +W ++ + Sbjct: 179 ----KIPEESQLVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALQREAH 233 Query: 282 ----------RIEDQQLGIIWTKQALVSISANGFINFVNPELG------SIDQVRYGHNK 325 + + + + S + + G D G Sbjct: 234 GLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVG--- 290 Query: 326 AITALSSSADGKTLFS--ADAEGHINSWDISTGI 357 I +L S+ G L + W I Sbjct: 291 FINSLKFSSSGDFLVAGVGQEHRLGRWWRIKEAR 324 Score = 113 bits (283), Expect = 2e-25, Method: Composition-based stats. Identities = 38/342 (11%), Positives = 96/342 (28%), Gaps = 37/342 (10%) Query: 97 TTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLT-----------G 145 + + + + I + + + ++G + G Sbjct: 8 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIK--WSVESGRKLHVIPRAKKGAEGKPPG 65 Query: 146 QARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLF 205 + + + + + SG + I+E + TF H V + + Sbjct: 66 HSSHVLCMAISSDGKY-LASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 124 Query: 206 ASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKI 265 ST D ++ ++N + + H +V L + + D T+++ Sbjct: 125 YSTSHDRSVKVWNVAENSYVETL-------FGHQDAVAALDALSRECCVTAGGRDGTVRV 177 Query: 266 WNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQV-RYGH- 323 W + + G + + +I ++ +VS + +G + + R H Sbjct: 178 WKIPEESQL--VFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALQREAHG 234 Query: 324 ---------NKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDV--HATMITG 372 I+++++ + + + + W G I Sbjct: 235 LRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINS 294 Query: 373 IKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQP 414 +K +S GD ++ + L P Sbjct: 295 LKFSSSGDFLVAGVGQEHRLGRWWRIKEARNSVCIIPLRRVP 336 Score = 111 bits (278), Expect = 7e-25, Method: Composition-based stats. Identities = 41/247 (16%), Positives = 87/247 (35%), Gaps = 17/247 (6%) Query: 32 KIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQT 91 K +G ++ +P HS S G Y ASGD + IW+ Sbjct: 40 KWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSC 99 Query: 92 THILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNG--NLTGQARA 149 H+ T V +++ + ++ + R V +++ ++ L G A Sbjct: 100 QHLY--TFTGHRDAVSGLAFRRGTHQLYSTSHDRS----VKVWNVAENSYVETLFGHQDA 153 Query: 150 MNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTG 209 + ++D SR + +G D TV +++ P F H + + + S Sbjct: 154 VAALD-ALSRECCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLI-NEEHMVSGA 210 Query: 210 GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSG-----SVFGLTWSPDGTKIASASADKTIK 264 DG++ L+ G+ + + ++ G + + + +A+ S ++ Sbjct: 211 DDGSVALW-GLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVR 269 Query: 265 IWNVATL 271 +W Sbjct: 270 LWQCGEG 276 Score = 101 bits (250), Expect = 1e-21, Method: Composition-based stats. Identities = 33/167 (19%), Positives = 69/167 (41%), Gaps = 8/167 (4%) Query: 443 TEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNN 502 S + C+A+S+D +++A G + + +++ T H ++ +AF Sbjct: 62 KPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFT-GHRDAVSGLAFRRG 120 Query: 503 GAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIV 562 L +T R V ++VA N ++ + H VA + + G D +V V Sbjct: 121 THQLYSTSHDRSVKVWNVAEN---SYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRV 177 Query: 563 WNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 W + + S + ++ ++ + NE +VS D ++ W + Sbjct: 178 WKIPEESQ-LVFYGHQGSIDCIHLI---NEEHMVSGADDGSVALWGL 220 Score = 93.0 bits (229), Expect = 4e-19, Method: Composition-based stats. Identities = 56/343 (16%), Positives = 104/343 (30%), Gaps = 62/343 (18%) Query: 276 TIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRY-----------GHN 324 + G ++ L + A+ S + + I + E G V GH+ Sbjct: 8 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 67 Query: 325 KAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTV 384 + ++ S+DGK L S D I W+ + F H ++G+ Sbjct: 68 SHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTG-HRDAVSGLAFRRGTHQLYS 126 Query: 385 SWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTE 444 + D V +S L D A+ A + Sbjct: 127 TSHDRSVKVWNVAE------------NSYVETLFGHQDAVAALDALSR------------ 162 Query: 445 VPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGA 504 C V GG+D V V+K+ S H I + N Sbjct: 163 -------ECC--------VTAGGRDGTVRVWKIPEESQLVFY--GHQGSIDCIHL-INEE 204 Query: 505 FLVATDQSRKVIPYSVANNFELAHTNSWTFHTAK--------VACVSWSPDNVRLATGSL 556 +V+ V + ++ LA + ++ V+ + +ATGS Sbjct: 205 HMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSH 264 Query: 557 DNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAG 599 + V +W + ++ + +NS+ + + + AG Sbjct: 265 SSCVRLWQCGEGFRQLDLLCDIPLVGFINSLKFSSSGDFLVAG 307 Score = 45.6 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 16/95 (16%), Positives = 33/95 (34%), Gaps = 9/95 (9%) Query: 523 NFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKG----- 577 E A H + C+ +PD+ + + + D S+I W++ +I + Sbjct: 1 GPEAADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAE 60 Query: 578 ----AHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 H+ + I + + S + I W Sbjct: 61 GKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWE 95 >3ACP-A nrPDB Length = 417 Score = 123 bits (307), Expect = 3e-28, Method: Composition-based stats. Identities = 52/293 (17%), Positives = 98/293 (33%), Gaps = 37/293 (12%) Query: 128 FGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFG 187 GH FLF+T +G+ + +VD + R I G+ + + + + + Sbjct: 74 DGHDFLFNTIIRDGSKMLKRADYTAVDTAKLQMRRFILGTTEGDIKVLDSNFNLQREIDQ 133 Query: 188 EHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW 247 H + +++ P G S+ D + +++ DG+ + H +V + Sbjct: 134 AHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTL-------IGHRATVTDIAI 186 Query: 248 SPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLG---IIWTKQALVSISANG 304 G + SAS D TI++W T T D + T + L IS + Sbjct: 187 IDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEISTSK 246 Query: 305 FINFVNPELGSIDQVRYGHNKAITAL---------------------SSSADG---KTLF 340 N G V GH + + S + DG ++ Sbjct: 247 KNNLEFGTYGKY--VIAGHVSGVITVHNVFSKEQTIQLPSKFTCSCNSLTVDGNNANYIY 304 Query: 341 SADAEGHINSWDISTGIS-NRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKV 392 + G + WD+ + F T I + + + +D +K+ Sbjct: 305 AGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFAAGALFVSSGFDTSIKL 357 Score = 79.5 bits (194), Expect = 4e-15, Method: Composition-based stats. Identities = 39/319 (12%), Positives = 95/319 (29%), Gaps = 25/319 (7%) Query: 247 WSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFI 306 + G+ + A D ++N K + + + + + G I Sbjct: 61 FEKVGSHLYKARLDGHDFLFNTIIRDGSKMLKRADYTAVDTAKLQMRR--FILGTTEGDI 118 Query: 307 NFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVH 366 ++ ++ H IT L G+ L S+ + + W + G + R H Sbjct: 119 KVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLIG-H 177 Query: 367 ATMITGIKTTSKG-DLFTVSWDDHLKVVPAG-GSGVDSSKAVANKLSSQPLGLAVSADGD 424 +T I +G ++ + S D +++ G G+ + + N Sbjct: 178 RATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALF----- 232 Query: 425 IAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSE 484 + + S K + + ++V G + V+ + + Sbjct: 233 ---VGTDRQLHEISTSK---------KNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTI 280 Query: 485 VKTIVHPAEITSVAFS-NNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVS 543 S+ NN ++ A ++ + + + + E + V Sbjct: 281 QLPSKFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLR-SPECPVGEFLINEGTPINNVY 339 Query: 544 WSPDNVRLATGSLDNSVIV 562 ++ + D S+ + Sbjct: 340 FAA-GALFVSSGFDTSIKL 357 Score = 61.4 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 40/245 (16%), Positives = 76/245 (31%), Gaps = 49/245 (20%) Query: 53 EIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWD 112 EI H + T K PSG S ++IW ++ T+ V DI+ Sbjct: 130 EIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNP--RTLIGHRATVTDIAII 187 Query: 113 SESKRIAAVGEGRERFGHVFLFD--TGTSNGNL----TGQARAMNSVDF--KPSRPFRII 164 + + + G + L++ TGT+ +NS+ R I Sbjct: 188 DRGRNVLSASLD----GTIRLWECGTGTTIHTFNRKENPHDG-VNSIALFVGTDRQLHEI 242 Query: 165 SGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVR--YNP---------------------- 200 S S N + G K+ H V +V ++ Sbjct: 243 STSKKNNLEF--GTYGKYV--IAGHVSGVITVHNVFSKEQTIQLPSKFTCSCNSLTVDGN 298 Query: 201 DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASAD 260 + + + +G + ++ + L N + + ++ G S+ D Sbjct: 299 NANYIYAGYENGMLAQWDLRSPECP---VGEFLINEG--TPINNVYFAA-GALFVSSGFD 352 Query: 261 KTIKI 265 +IK+ Sbjct: 353 TSIKL 357 Score = 57.2 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 20/108 (18%), Positives = 43/108 (39%), Gaps = 8/108 (7%) Query: 502 NGAFLVATDQ-SRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSV 560 F++ T + KV+ + E+ H +++ + + P L + S D + Sbjct: 106 MRRFILGTTEGDIKVLDSNFNLQREIDQA-----HVSEITKLKFFPSGEALISSSQDMQL 160 Query: 561 IVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 +W++ S+ +I H + + I ++SA D I+ W Sbjct: 161 KIWSVKDGSNPRTLI--GHRATVTDIAIIDRGRNVLSASLDGTIRLWE 206 >4A11-B nrPDB Length = 408 Score = 120 bits (300), Expect = 2e-27, Method: Composition-based stats. Identities = 51/330 (15%), Positives = 108/330 (32%), Gaps = 32/330 (9%) Query: 51 DTEIYTEHSHQTTVAKTSP-SGYYCASGDVHGNVRIWDTTQT-----------THILKTT 98 D ++ H P G Y SG G + ++D + I + Sbjct: 35 DRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDH 94 Query: 99 IPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPS 158 V V+ + W + ++ V+ +T + + + S P Sbjct: 95 PDVHRYSVETVQWYPHDTGMFTSSS-FDKTLKVWDTNTLQTADVFNFEE-TVYSHHMSPV 152 Query: 159 RPFR--IISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSL-FASTGGDGTIV 215 + G+ V + + H + + +V ++P A+ D + Sbjct: 153 STKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVK 212 Query: 216 LYNGVDGT-KTGVFEDDSLK--------NVAHSGSVFGLTWSPDGTKIASASADKTIKIW 266 L++ + + + K N AH+G V GL ++ DG + + D +++W Sbjct: 213 LWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLW 272 Query: 267 NVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISA-----NGFINFVNPELGSIDQVRY 321 N + + + G + + G+ +T S I G + Sbjct: 273 NSSNGENTL-VNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLK 331 Query: 322 GHNKAITALSSSADGKTLFSADAEGHINSW 351 GH K + ++ + L+S + +I +W Sbjct: 332 GHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 Score = 101 bits (250), Expect = 1e-21, Method: Composition-based stats. Identities = 50/363 (13%), Positives = 113/363 (31%), Gaps = 76/363 (20%) Query: 146 QARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFG-------------EHTKF 192 +N++D +P ++SG D + +++ +S + H Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 193 VHSVRYNPDGS-LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG 251 V +V++ P + +F S+ D T+ +++ VF + H V S Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPV-----STKH 156 Query: 252 TKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA---LVSISANGFINF 308 +A + +++ ++ + + + + L + W+ + L + SA+ + Sbjct: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQGHRQ---EILAVSWSPRYDYILATASADSRVKL 213 Query: 309 VNPELGS----------------IDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 + S ++ HN + L ++DG L + + + W+ Sbjct: 214 WDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 Query: 353 ISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSS 412 S G + V ++ KV G+ + + Sbjct: 274 SSNGENTLV--------------------------NYGKVCNNSKKGLKFTVSC----GC 303 Query: 413 QPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKV 472 + V IAV Y I C ++ Q + G +D + Sbjct: 304 SSEFVFVPYGSTIAVYTVYSGEQITMLK-----GHYKTVDCCVFQSNFQELYSGSRDCNI 358 Query: 473 HVY 475 + Sbjct: 359 LAW 361 Score = 95.7 bits (236), Expect = 5e-20, Method: Composition-based stats. Identities = 47/274 (17%), Positives = 91/274 (33%), Gaps = 26/274 (9%) Query: 58 HSHQTTVAKTSP-SGYYCASGDVHGNVRIWDTT--QTTHILKTTIPVFSGPVKDISWDSE 114 H + + P S +++WDT QT + V+S + +S Sbjct: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVS---- 153 Query: 115 SKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAI 174 +K R + +G+ + L G + + +V + P + + + S D+ V + Sbjct: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKL 213 Query: 175 FEGPPFK-FKSTF---------------GEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN 218 ++ T H V+ + + DG + G D + L+N Sbjct: 214 WDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 Query: 219 GVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIP 278 +G T V + N + G F ++ + TI ++ V + + + T+ Sbjct: 274 SSNGENTLV-NYGKVCNNSKKGLKFTVSCGCSSEFVFVPYG-STIAVYTVYSGE-QITML 330 Query: 279 VGTRIEDQQLGIIWTKQALVSISANGFINFVNPE 312 G Q L S S + I P Sbjct: 331 KGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPS 364 Score = 71.8 bits (174), Expect = 8e-13, Method: Composition-based stats. Identities = 35/188 (18%), Positives = 69/188 (36%), Gaps = 20/188 (10%) Query: 438 SHGKLTEVPISYNSSCVALSN-DKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITS 496 S G+ Y+ V D D + V+ + ++V Sbjct: 89 SIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHH 148 Query: 497 VAFSNNGAFLVA-TDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVR-LATG 554 ++ + LVA + KV + + + ++ H ++ VSWSP LAT Sbjct: 149 MSPVSTKHCLVAVGTRGPKVQLCDLKSG---SCSHILQGHRQEILAVSWSPRYDYILATA 205 Query: 555 SLDNSVIVWNMNKPSDHPIIIKGAHAMSS-------------VNSVIW-LNETTIVSAGQ 600 S D+ V +W++ + S I + + S VN + + + +++ G Sbjct: 206 SADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGT 265 Query: 601 DSNIKFWN 608 D+ ++ WN Sbjct: 266 DNRMRLWN 273 Score = 67.2 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 50/375 (13%), Positives = 105/375 (28%), Gaps = 87/375 (23%) Query: 302 ANGFINFVNPELGSIDQVRYGHNKAITALSSSA-DGKTLFSADAEGHINSWDI-----ST 355 A + EL V H I L +G+ + S ++G I +D+ + Sbjct: 21 AESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQS 80 Query: 356 GISNRVF-------PDVHATMITGI--KTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAV 406 + + PDVH + + G + S+D LKV Sbjct: 81 YYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNF 140 Query: 407 ANKLSSQPLGLAVSADGDIAVAACYKHIAIY-------SHGKLTEVPISYNSSCVALSND 459 + S ++ + VA + + S + + V+ S Sbjct: 141 EETVYSH--HMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQ-GHRQEILAVSWSPR 197 Query: 460 KQFV-AVGGQDSKVHVYKLSGAS---------------VSEVKTIVHPAEITSVAFSNNG 503 ++ A DS+V ++ + AS E H ++ + F+++G Sbjct: 198 YDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDG 257 Query: 504 AFLVATDQSRKVIPYSVANN---------------------------------------- 523 L+ ++ ++ +N Sbjct: 258 LHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIA 317 Query: 524 ----FELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVW--NMNKPSDHPIIIKG 577 + H V C + + L +GS D +++ W ++ +P Sbjct: 318 VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTT 377 Query: 578 AHAMSSVNSVIWLNE 592 ++ W + Sbjct: 378 KSQLNPAFEDAWSSS 392 Score = 59.1 bits (141), Expect = 5e-09, Method: Composition-based stats. Identities = 27/192 (14%), Positives = 67/192 (34%), Gaps = 28/192 (14%) Query: 438 SHGKLTEVPISYNSSCVALSN-DKQFVAVGGQDSKVHVYKLSGASVSEVKT--------- 487 + + E + + + + +++ GG D + +Y L +S T Sbjct: 33 NKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGR 92 Query: 488 ---IVHPAEITSVAFSNNGAFLV-ATDQSRKVIPYSVAN----NFELAHTNSWTFHTAKV 539 VH + +V + + + ++ + + + + ++ H + V Sbjct: 93 DHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPV 152 Query: 540 ACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLN--ETTIVS 597 S + +A G+ V + ++ S I+ + +V W + + + Sbjct: 153 -----STKHCLVAVGTRGPKVQLCDLKSGSCSHIL---QGHRQEILAVSWSPRYDYILAT 204 Query: 598 AGQDSNIKFWNV 609 A DS +K W+V Sbjct: 205 ASADSRVKLWDV 216 >4BZK-B nrPDB Length = 297 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 48/264 (18%), Positives = 88/264 (33%), Gaps = 28/264 (10%) Query: 29 AGDKIQYCNGTS---VYTVPVGSLTDTEIYTEHSHQTTVAKTSPS--GYYCASGDVHGNV 83 G ++ C+ ++ V + + T H + G AS G V Sbjct: 20 YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKV 79 Query: 84 RIWDTTQTTHILKTTIPVFSGPVKDISW--DSESKRIAAVGEGRERFGHVFLFDTGTSNG 141 IW V S V + W + + F + TS Sbjct: 80 LIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI 139 Query: 142 NLTGQARAMNSVDFKPS------------RPFRIISGSDDNTVAIF----EGPPFKFKST 185 + A +NS + P+ + ++G DN V I+ + + +ST Sbjct: 140 IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLEST 199 Query: 186 FGEHTKFVHSVRYNPD---GSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSV 242 H+ +V V ++P S AS D T +++ + G ++ LK + Sbjct: 200 LEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW--TQDNEQGPWKKTLLKEEKFPDVL 257 Query: 243 FGLTWSPDGTKIASASADKTIKIW 266 + +WS G +A + D + +W Sbjct: 258 WRASWSLSGNVLALSGGDNKVTLW 281 Score = 107 bits (266), Expect = 2e-23, Method: Composition-based stats. Identities = 52/281 (18%), Positives = 93/281 (33%), Gaps = 28/281 (9%) Query: 54 IYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS 113 I H+ A G A+ ++I++ TH L T+ GPV + W Sbjct: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 Query: 114 ESKRIAAVGEGRERFGHVFLFDTG--TSNGNLTGQARAMNSVDFKP-SRPFRIISGSDDN 170 + ++ + G + + ++NSV + P ++ S D Sbjct: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 Query: 171 TVAI--FEGPPFKFKSTFGEHTKFVHSVRYNP-----DGSL--------FASTGGDGTIV 215 V++ F+ H V+S + P DG F + G D + Sbjct: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 Query: 216 LYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD---GTKIASASADKTIKIW--NVAT 270 ++ +T V E HS V + WSP + +AS S D+T IW + Sbjct: 184 IWKYNSDAQTYVLE---STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 Query: 271 LKVEKTIPVGTRIEDQ--QLGIIWTKQALVSISANGFINFV 309 +KT+ + D + + L + + Sbjct: 241 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 91.1 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 50/312 (16%), Positives = 91/312 (29%), Gaps = 39/312 (12%) Query: 274 EKTIPVGTRIEDQQLGIIWTKQALVSISANGFINF--VNPELGSIDQVRYGHNKAITALS 331 I + + + L + S++ I V E + GH + + Sbjct: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 Query: 332 SS--ADGKTLFSADAEGHINSWDISTGISNRV-FPDVHATMITGIKTTSK--GDLFTVSW 386 + G L S +G + W G +++ VH+ + ++ G L V+ Sbjct: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 Query: 387 DDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVP 446 D V + +G + H + Sbjct: 121 SDGKVSV-----------------------VEFKENGTTSPIIIDAHAIGVNSASWAPAT 157 Query: 447 ISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKT---IVHPAEITSVAFSNN- 502 I + ++FV GG D+ V ++K + + + V H + VA+S Sbjct: 158 IEEDGEHNGTKESRKFV-TGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV 216 Query: 503 --GAFLVATDQSRKVIPY--SVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDN 558 ++L + Q R I + + SWS LA DN Sbjct: 217 LLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDN 276 Query: 559 SVIVWNMNKPSD 570 V +W N Sbjct: 277 KVTLWKENLEGK 288 Score = 78.0 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 51/331 (15%), Positives = 96/331 (29%), Gaps = 67/331 (20%) Query: 188 EHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW 247 H + +H + G A+ D TI ++ T + H G V+ + W Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLI-----DTLTGHEGPVWRVDW 61 Query: 248 -SPD-GTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQ----ALVSIS 301 P GT +AS S D + IW + I V + W L+ S Sbjct: 62 AHPKFGTILASCSYDGKVLIWKEENGR-WSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 Query: 302 ANGFINFVNPELGSIDQ--VRYGHNKAITALSSSA-----DG--------KTLFSADAEG 346 ++G ++ V + + H + + S + DG + + A+ Sbjct: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 Query: 347 HINSWDISTGISNRVF---PDVHATMITGIKTTSK---GDLFTVSWDDHLKVVPAGGSGV 400 + W ++ V + H+ + + + D ++ + Sbjct: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 Query: 401 DSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDK 460 K K P L ++ S Sbjct: 241 GPWKKTLLKEEKFPDVLWRAS----------------------------------WSLSG 266 Query: 461 QFVAVGGQDSKVHVYKLSGASVSEVKTIVHP 491 +A+ G D+KV ++K + E VH Sbjct: 267 NVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 Score = 73.8 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 37/168 (22%), Positives = 59/168 (35%), Gaps = 21/168 (12%) Query: 460 KQFVAVGGQDSKVHVYKLSGASVSEVKT-IVHPAEITSVAF-SNN-GAFLVATDQSRKVI 516 + +A D + ++++ G + + T H + V + G L + KV+ Sbjct: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 Query: 517 PYSVANNFELAHTNSWTFHTAKVACVSWSPD--NVRLATGSLDNSVIVWNMNKPSDHPII 574 + N + H+A V V W+P L S D V V + I Sbjct: 81 IWKEENG-RWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI 139 Query: 575 IKGAHAMSSVNSVIWLNETT--------------IVSAGQDSNIKFWN 608 I AHA+ VNS W T V+ G D+ +K W Sbjct: 140 IIDAHAI-GVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 Score = 69.9 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 35/169 (20%), Positives = 55/169 (32%), Gaps = 22/169 (13%) Query: 460 KQFVAVGGQDSKVHVYKLSGASVSEVKT-IVHPAEITSVAFSNN--GAFLVATDQSRKVI 516 +A D KV ++K S++ VH A + SV ++ + G L+ KV Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 517 PYSVANNFELAHTNSWTFHTAKVACVSWSP-------------DNVRLATGSLDNSVIVW 563 N H V SW+P ++ + TG DN V +W Sbjct: 127 VVEFKEN-GTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 Query: 564 NMNKPSDHPII-IKGAHAMSSVNSVIWLNE----TTIVSAGQDSNIKFW 607 N + ++ V V W + + S QD W Sbjct: 186 KYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 16/79 (20%), Positives = 27/79 (34%), Gaps = 4/79 (5%) Query: 533 TFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNE 592 H + RLAT S D ++ ++ + + H +I V V W + Sbjct: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGET-HKLIDTLTGHEGPVWRVDWAHP 64 Query: 593 ---TTIVSAGQDSNIKFWN 608 T + S D + W Sbjct: 65 KFGTILASCSYDGKVLIWK 83 >6ELZ-p nrPDB Length = 460 Score = 116 bits (290), Expect = 3e-26, Method: Composition-based stats. Identities = 57/359 (15%), Positives = 121/359 (33%), Gaps = 36/359 (10%) Query: 278 PVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGK 337 L + + ++S S +G + + G++ + GH+ I A+ ++ Sbjct: 99 SFSNEDWVSSLDVGDGSKHIISGSYDGIVRTWDL-SGNVQKQYSGHSGPIRAVKYISN-T 156 Query: 338 TLFSADAEGHINSW-----------------------DISTGISNRVFPDVHATMITGIK 374 L SA + + W +I G + + H + I Sbjct: 157 RLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEG-HKAPVVSID 215 Query: 375 TTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHI 434 + + + S+D+ + + + + +++ ++ +A + I Sbjct: 216 VSDNSRILSASYDNSIGFWSTIYKEMTVVDPLED-INNPNNKISTAARKRRKLTMKDGTI 274 Query: 435 AIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEI 494 + L E + + S D QD + + L A + +T + + Sbjct: 275 RRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYS--L 332 Query: 495 TSVAFSNNGAFLVATDQSRKVIPYSVANNFEL-AHTNSWTFHTAKVACVSWSPDNVR-LA 552 S+A + L +R + + H V+ + P+N L Sbjct: 333 LSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILC 392 Query: 553 TGSLDNSVIVWNMNKPSDHPIIIKGAHAMS-----SVNSVIWLNETTIVSAGQDSNIKF 606 +GS D +V VW++ S I + ++ V +V W + I+SAGQD I+ Sbjct: 393 SGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVKWAEKVGIISAGQDKKIQI 451 Score = 105 bits (261), Expect = 6e-23, Method: Composition-based stats. Identities = 60/388 (15%), Positives = 124/388 (31%), Gaps = 50/388 (12%) Query: 188 EHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW 247 + +V S+ S DG + ++ G + HSG + + + Sbjct: 101 SNEDWVSSLDVGDGSKHIISGSYDGIVRTWDL-SGNVQKQYS-------GHSGPIRAVKY 152 Query: 248 SPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFIN 307 + + SA D+T+++W ++ T + +D Sbjct: 153 ISNTR-LVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDE------------------- 192 Query: 308 FVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHA 367 VN E G + GH + ++ S D + SA + I W V P Sbjct: 193 -VNIEDGKTLAILEGHKAPVVSIDVS-DNSRILSASYDNSIGFWSTIYKEMTVVDPLEDI 250 Query: 368 TMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKL----SSQPLGLAVSADG 423 +T+ ++ D A S ++S A ++ + +G +VS D Sbjct: 251 NNPNNKISTAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDH 310 Query: 424 DIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLS---GA 480 K + + + SY+ +A + +A G + ++ + Sbjct: 311 T------IKTWDLVTARCIDTRTTSYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASS 364 Query: 481 SVSEVKTIVHPAEITSVAFSN-NGAFLVATDQSRKVIPYSVANNFELAHTNS-----WTF 534 V++ + I H ++S+ N L + V + V + + Sbjct: 365 KVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKG 424 Query: 535 HTAKVACVSWSPDNVRLATGSLDNSVIV 562 KV V W+ + V + + D + + Sbjct: 425 VNDKVFAVKWA-EKVGIISAGQDKKIQI 451 Score = 101 bits (250), Expect = 1e-21, Method: Composition-based stats. Identities = 58/398 (14%), Positives = 128/398 (32%), Gaps = 76/398 (19%) Query: 147 ARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFA 206 ++S+D IISGS D V ++ + + H+ + +V+Y + + Sbjct: 103 EDWVSSLDVG-DGSKHIISGSYDGIVRTWDL-SGNVQKQYSGHSGPIRAVKYISN-TRLV 159 Query: 207 STGGDGTIVLYNGVDGTKTGVFEDDSLKNV----------------AHSGSVFGLTWSPD 250 S G D T+ L+ + + + ++ H V + S D Sbjct: 160 SAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVS-D 218 Query: 251 GTKIASASADKTIKIWN--VATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINF 308 ++I SAS D +I W+ + V + ++ ++ L +G I Sbjct: 219 NSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTM--KDGTIRR 276 Query: 309 VNPELGSIDQVRYGHNKAITALSSSADGKTL-FSADAEGHINSWDISTGISNRVFPDVHA 367 P + H + + + T+ +S + I +WD+ T Sbjct: 277 RAP-----LSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDT------ 325 Query: 368 TMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAV 427 T+ L +++ L ++ G S + D + Sbjct: 326 -------RTTSYSLLSIAQLSTLNLLACGSSARHITLH----------------DPRVGA 362 Query: 428 AACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVA-VGGQDSKVHVYKLSGASVSEVK 486 ++ + H +S +C + +++ G D V V+ + S Sbjct: 363 SSKVTQQQLIGHKN----FVSSLDTC----PENEYILCSGSHDGTVKVWDVRSTSPMYTI 414 Query: 487 TIVHP-------AEITSVAFSNNGAFLVATDQSRKVIP 517 T ++ +V ++ +++ Q +K+ Sbjct: 415 TREDKSVQKGVNDKVFAVKWA-EKVGIISAGQDKKIQI 451 Score = 98.8 bits (244), Expect = 6e-21, Method: Composition-based stats. Identities = 54/351 (15%), Positives = 99/351 (28%), Gaps = 109/351 (31%) Query: 62 TTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAV 121 + + SG G VR WD + ++ SGP++ + + S ++ ++A Sbjct: 106 VSSLDVGDGSKHIISGSYDGIVRTWDLS---GNVQKQYSGHSGPIRAVKYISNTRLVSAG 162 Query: 122 GEGRERFGHVFLFD--------------------TGTSNGNLTGQARAMNSVDFKPSRPF 161 + R D G + L G + S+D + Sbjct: 163 NDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVSDNS-- 220 Query: 162 RIISGSDDNTVAIF--------------EGPPFK------------------------FK 183 RI+S S DN++ + + Sbjct: 221 RILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGTIRRRAPL 280 Query: 184 STFGEHTKFVHSVRYNPDGSLFA-STGGDGTIVLYNGVDGTKTG---------------- 226 S HT V V ++ + S D TI ++ V Sbjct: 281 SLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYSLLSIAQLST 340 Query: 227 -------------VFEDDSL---------KNVAHSGSVFGLTWSP-DGTKIASASADKTI 263 D + + + H V L P + + S S D T+ Sbjct: 341 LNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTV 400 Query: 264 KIWNVATLKVEKTI-----PVGTRIEDQQLGIIWTKQ-ALVSISANGFINF 308 K+W+V + TI V + D+ + W ++ ++S + I Sbjct: 401 KVWDVRSTSPMYTITREDKSVQKGVNDKVFAVKWAEKVGIISAGQDKKIQI 451 Score = 78.4 bits (191), Expect = 8e-15, Method: Composition-based stats. Identities = 32/205 (15%), Positives = 57/205 (27%), Gaps = 18/205 (8%) Query: 26 NTPAGDKIQYCNGTSVYTVPVGSLTDTEIYT---EHSHQTTVAKTSPSGYYCA-SGDVHG 81 N P T+ G++ + H+ + S Sbjct: 251 NNPNNKISTAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDH 310 Query: 82 NVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLF--DTGTS 139 ++ WD I T + +S +A R H + + Sbjct: 311 TIKTWDLVTARCIDTRTTSYSLLSIAQLS---TLNLLACGSSARHITLHDPRVGASSKVT 367 Query: 140 NGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTF--------GEHTK 191 L G ++S+D P + + SGS D TV +++ T Sbjct: 368 QQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVND 427 Query: 192 FVHSVRYNPDGSLFASTGGDGTIVL 216 V +V++ S G D I + Sbjct: 428 KVFAVKWAEKVG-IISAGQDKKIQI 451 Score = 60.7 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 40/232 (17%), Positives = 68/232 (29%), Gaps = 61/232 (26%) Query: 435 AIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEI 494 AI L S + + + + + G D V + LSG + + H I Sbjct: 90 AILPPSYLNSFSNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLSGN--VQKQYSGHSGPI 147 Query: 495 TSVAFSNNGAFLVATDQSRKVIPYSVANN--------------------FELAHTNSWTF 534 +V + +N LV+ R + + N+ + Sbjct: 148 RAVKYISNTR-LVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEG 206 Query: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPI--------------------- 573 H A V + S DN R+ + S DNS+ W+ + Sbjct: 207 HKAPVVSIDVS-DNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRR 265 Query: 574 --------------IIKGAHAMSSVNSVIW--LNETTIVSAGQDSNIKFWNV 609 + + V VI+ + T S QD IK W++ Sbjct: 266 KLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDL 317 >5OQL-L nrPDB Length = 557 Score = 115 bits (287), Expect = 6e-26, Method: Composition-based stats. Identities = 46/267 (17%), Positives = 94/267 (35%), Gaps = 27/267 (10%) Query: 97 TTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTG-----QARAMN 151 TI F + + + A + G + +FD G + + + Sbjct: 93 KTIGRFDSEAHCGEIRPDGRVLVAGED----TGRMQVFDVGQGTRAVILKTWHIHKQPVW 148 Query: 152 SVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNP---DGSLFAST 208 + P+ ++S SDD TV +++ P F HT +V + P + +L S Sbjct: 149 VTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSG 208 Query: 209 GGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNV 268 D T+ +++ ++ H+ + + P GT + +AS I + ++ Sbjct: 209 SYDETVRVWDARA-------PGGAVMTFKHADPIEDVLPLPSGTTLLAASG-NAISVLDL 260 Query: 269 ATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAIT 328 K + I + L + + +VS S +G + ++ + I Sbjct: 261 VAAKPLRLITNHQK-TVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVA-GAKYPSPIL 318 Query: 329 ALSS-----SADGKTLFSADAEGHINS 350 +LS S D + L G ++ Sbjct: 319 SLSVITAGASHDDRHLAVGMQSGVLSI 345 Score = 112 bits (279), Expect = 6e-25, Method: Composition-based stats. Identities = 36/256 (14%), Positives = 92/256 (35%), Gaps = 24/256 (9%) Query: 109 ISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNL--TGQARAMNSVDFKPSRPFRIISG 166 ++ + A R + + + G + P +++G Sbjct: 64 VAAAKTNDLFAVTAGPRVEIFSIRKREPLKTIGRFDSEAHCGEIR-----PDGRV-LVAG 117 Query: 167 SDDNTVAIFEGPPFK---FKSTFGEHTKFVHSVRYNPDG-SLFASTGGDGTIVLYNGVDG 222 D + +F+ T+ H + V +++P + S D T+ L++ Sbjct: 118 EDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSN 177 Query: 223 TKTGVFEDDSLKNVAHSGSVFGLTWSP---DGTKIASASADKTIKIWNVATLKVEKTIPV 279 D + H+ V + P + + S S D+T+++W+ + Sbjct: 178 -------DPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPG-GAVMTF 229 Query: 280 GTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTL 339 + + + + L++ S I+ ++ ++ H K +T+LS ++ G+ + Sbjct: 230 KHADPIEDVLPLPSGTTLLAASG-NAISVLDLVAAKPLRLITNHQKTVTSLSLASQGRRV 288 Query: 340 FSADAEGHINSWDIST 355 S +GH+ ++ ++ Sbjct: 289 VSGSLDGHVKVFETTS 304 Score = 93.4 bits (230), Expect = 3e-19, Method: Composition-based stats. Identities = 41/239 (17%), Positives = 88/239 (36%), Gaps = 17/239 (7%) Query: 377 SKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAI 436 K T +W PA + + AV+A + + + K + Sbjct: 33 QKSHTSTANWPISHISFPASLGTTALVSSSLVAAAKTNDLFAVTAGPRVEIFSIRKREPL 92 Query: 437 YSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVK--TIVHPAEI 494 + G+ C + D + + G ++ V+ + + + + +H + Sbjct: 93 KTIGRFDSEAH-----CGEIRPDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPV 147 Query: 495 TSVAFSNNG-AFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSW---SPDNVR 550 +S L++ + V + + +N T +T HT V C ++ S ++ Sbjct: 148 WVTKWSPTELTTLMSCSDDKTVRLWDLPSNDP---TRLFTGHTDYVRCGAFMPGSANSNL 204 Query: 551 LATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 L +GS D +V VW+ P + K A + V + + TT+++A + I ++ Sbjct: 205 LVSGSYDETVRVWDARAPGGAVMTFKHADPIEDV--LPLPSGTTLLAASG-NAISVLDL 260 Score = 87.6 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 43/246 (17%), Positives = 71/246 (28%), Gaps = 22/246 (8%) Query: 17 ARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSG-YYCA 75 G +V G G + G V + + H V K SP+ Sbjct: 109 PDGRVLVAGED-TGRMQVFDVGQGTRAVILKTWHI------HKQPVWVTKWSPTELTTLM 161 Query: 76 SGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISW---DSESKRIAAVGEGRERFGHVF 132 S VR+WD T + V+ ++ + S + V + V+ Sbjct: 162 SCSDDKTVRLWDLPSNDPTRLFT--GHTDYVRCGAFMPGSANSNLL--VSGSYDETVRVW 217 Query: 133 LFDT-GTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTK 191 G + A + V PS + + N +++ + K H K Sbjct: 218 DARAPGGAVMTFK-HADPIEDVLPLPSGTTLLAASG--NAISVLDLVAAKPLRLITNHQK 274 Query: 192 FVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG 251 V S+ G S DG + ++ + S S SV S D Sbjct: 275 TVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAGAKYPSPIL---SLSVITAGASHDD 331 Query: 252 TKIASA 257 +A Sbjct: 332 RHLAVG 337 Score = 79.5 bits (194), Expect = 4e-15, Method: Composition-based stats. Identities = 34/205 (16%), Positives = 65/205 (31%), Gaps = 17/205 (8%) Query: 22 VVLGNTPAG-DKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAKTSP---SGYYCAS 76 V +P + C+ + + S T ++T H+ P + S Sbjct: 148 WVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVS 207 Query: 77 GDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDT 136 G VR+WD + T + P++D+ + A V Sbjct: 208 GSYDETVRVWDARAPGGAVMT--FKHADPIEDVLPLPSGTTLLAASG---NAISVLDLVA 262 Query: 137 GTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSV 196 +T + + S+ S+ R++SGS D V +FE + + + S+ Sbjct: 263 AKPLRLITNHQKTVTSLSLA-SQGRRVVSGSLDGHVKVFETTSWNVVAGAKY-PSPILSL 320 Query: 197 RY-----NPDGSLFASTGGDGTIVL 216 + D A G + + Sbjct: 321 SVITAGASHDDRHLAVGMQSGVLSI 345 Score = 66.0 bits (159), Expect = 5e-11, Method: Composition-based stats. Identities = 61/384 (15%), Positives = 108/384 (28%), Gaps = 78/384 (20%) Query: 249 PDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINF 308 P G +A + W + T I ALVS S Sbjct: 14 PSGPSPITAEQ----RYWRSFKKQKSHTSTANWPISHISFPASLGTTALVSSSL-----V 64 Query: 309 VNPELGSIDQVRYGHNKAITAL-------------------SSSADGKTLFSADAEGHIN 349 + + V G I ++ DG+ L + + G + Sbjct: 65 AAAKTNDLFAVTAGPRVEIFSIRKREPLKTIGRFDSEAHCGEIRPDGRVLVAGEDTGRMQ 124 Query: 350 SWDISTGISNRVFPD--VHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVA 407 +D+ G + +H + K + +S D D + + Sbjct: 125 VFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSD------------DKTVRLW 172 Query: 408 NKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGG 467 + S+ P L G C + S + + G Sbjct: 173 DLPSNDPTRLFT---GHTDYVRCGAFMP--------------------GSANSNLLVSGS 209 Query: 468 QDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELA 527 D V V+ + V T H I V +G L+A + + + L Sbjct: 210 YDETVRVWDARAPGGA-VMTFKHADPIEDVLPLPSGTTLLAASGN-AISVLDLVAAKPL- 266 Query: 528 HTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIV-----WNMNKPSDHPIIIKGAHAMS 582 T H V +S + R+ +GSLD V V WN+ + +P I ++S Sbjct: 267 --RLITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAGAKYPSPIL---SLS 321 Query: 583 SVNSVIWLNETTIVSAGQDSNIKF 606 + + ++ + Q + Sbjct: 322 VITAGASHDDRHLAVGMQSGVLSI 345 Score = 56.4 bits (134), Expect = 4e-08, Method: Composition-based stats. Identities = 20/107 (18%), Positives = 37/107 (34%), Gaps = 5/107 (4%) Query: 506 LVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM 565 L A +V +S+ L + C PD L G + V+++ Sbjct: 72 LFAVTAGPRVEIFSIRKREPLKTIGRFDSEAH---CGEIRPDGRVLVAGEDTGRMQVFDV 128 Query: 566 NKPSDHPIIIKGAHAMSSVNSVIWLNE--TTIVSAGQDSNIKFWNVP 610 + + I+ V W TT++S D ++ W++P Sbjct: 129 GQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLP 175 >4L9O-A nrPDB Length = 349 Score = 115 bits (287), Expect = 7e-26, Method: Composition-based stats. Identities = 51/271 (18%), Positives = 91/271 (33%), Gaps = 20/271 (7%) Query: 56 TEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSES 115 H A G A+ ++I++ L T+ GPV ++W Sbjct: 66 NAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPK 125 Query: 116 KRIAAVGEGRERFGHVFLFDTG--TSNGNLTGQARAMNSVDFKP-SRPFRIISGSDDNTV 172 + + ++ D G + ++NSV + P ++ S D + Sbjct: 126 FGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKI 185 Query: 173 AIFEGPPFKFKS--TFGEHTKFVHSVRYNP-----DGSLFASTGGDGTIVLYNGVDGTKT 225 +I E H V++ + P + F S G D + ++ D KT Sbjct: 186 SIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKT 245 Query: 226 GVFEDDSLKNVAHSGSVFGLTWSPDG---TKIASASADKTIKIW--NVATLKVEKTIPVG 280 + E+ HS V + WSP + IA+AS D+T+ IW + + K EK Sbjct: 246 FIEEE---AFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTK 302 Query: 281 TRIEDQQ--LGIIWTKQALVSISANGFINFV 309 + D + L + + Sbjct: 303 EKFPDVCWRASWSLSGNVLAISGGDNKVTLW 333 Score = 93.4 bits (230), Expect = 3e-19, Method: Composition-based stats. Identities = 50/305 (16%), Positives = 100/305 (32%), Gaps = 49/305 (16%) Query: 276 TIPVGTRIEDQQLGIIWTKQALVSISANGFINF--VNPELGSIDQVRYGHNKAITALSSS 333 TI + + + L + S++ I ++ E + + GH + ++ + Sbjct: 63 TIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWA 122 Query: 334 --ADGKTLFSADAEGHINSWDISTGISNRVFP-DVHATMITGIKTTSKGDLFTVSWDDHL 390 G L S +G + W G+ N+V VH + + Sbjct: 123 HPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVS---------------- 166 Query: 391 KVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKH---IAIYSHGKLTEVPI 447 P+ L S+DG I++ I G V Sbjct: 167 ----------------WAPHEYGPVLLCASSDGKISIVEFKDGGALEPIVIQGHAIGVNA 210 Query: 448 SYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTI---VHPAEITSVAFSNN-- 502 + + ++L ++ + GG D+ V +++ A+ + ++ H + VA+S + Sbjct: 211 ASWAP-ISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSPSRL 269 Query: 503 -GAFLVATDQSRKVIPY--SVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNS 559 +++ Q R V+ + +N + SWS LA DN Sbjct: 270 SKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNK 329 Query: 560 VIVWN 564 V +W Sbjct: 330 VTLWK 334 Score = 77.6 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 34/161 (21%), Positives = 57/161 (35%), Gaps = 14/161 (8%) Query: 460 KQFVAVGGQDSKVHVYKLSGAS-VSEVKTIVHPAEITSVAFSNN--GAFLVATDQSRKVI 516 +A D KV ++K + VH A + SV+++ + G L+ K+ Sbjct: 127 GVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKIS 186 Query: 517 PYSVANNFELAHTNSWTFHTAKVACVSWSP-----DNVRLATGSLDNSVIVWNMNKPSDH 571 + L H V SW+P + R +G DN V +W + + Sbjct: 187 IVEFKDGGALE-PIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKT 245 Query: 572 PIIIKG-AHAMSSVNSVIWLN----ETTIVSAGQDSNIKFW 607 I + V V W ++ I +A QD + W Sbjct: 246 FIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIW 286 Score = 76.8 bits (187), Expect = 3e-14, Method: Composition-based stats. Identities = 37/162 (22%), Positives = 60/162 (37%), Gaps = 13/162 (8%) Query: 460 KQFVAVGGQDSKVHVYKLSGASVSEVKT-IVHPAEITSVAF-SNN-GAFLVATDQSRKVI 516 + +A D + ++++ G + V+T I H + VA+ G L + KV+ Sbjct: 81 GRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVL 140 Query: 517 PYSVANNFELAHTNSWTFHTAKVACVSWSPD--NVRLATGSLDNSVIVWNMNKPSDHPII 574 + N + H A V VSW+P L S D + + I Sbjct: 141 IWKEDNGVW-NKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPI 199 Query: 575 IKGAHAMSSVNSVIW------LNETTIVSAGQDSNIKFWNVP 610 + HA+ VN+ W N VS G D+ +K W Sbjct: 200 VIQGHAI-GVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYD 240 Score = 73.8 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 51/299 (17%), Positives = 100/299 (33%), Gaps = 47/299 (15%) Query: 237 AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA 296 AH + G ++A+ S+DKTIKI+ + + ++ + E + W Sbjct: 67 AHDDLIHDAVLDYYGRRLATCSSDKTIKIFEID-GENQRLVETLIGHEGPVWQVAWAHPK 125 Query: 297 ----LVSISANGFINFVNPELGSIDQVRYG--HNKAITALSSSA--DGKTLFSADAEGHI 348 L S S +G + + G ++V H ++ ++S + G L A ++G I Sbjct: 126 FGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKI 185 Query: 349 NSWDISTGISNR-VFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVA 407 + + G + + HA + +S D+ + +GG Sbjct: 186 SIVEFKDGGALEPIVIQGHAIGVNAASWAP------ISLPDNTRRFVSGG---------- 229 Query: 408 NKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSN---DKQFVA 464 D + + + + + + VA S K ++A Sbjct: 230 -------------CDNLVKIWRYDDAAKTFIEEEAFQGHSDW-VRDVAWSPSRLSKSYIA 275 Query: 465 VGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVA----FSNNGAFLVATDQSRKVIPYS 519 QD V ++ G S K + + V +S +G L + KV + Sbjct: 276 TASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLWK 334 Score = 46.0 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 18/92 (19%), Positives = 27/92 (29%), Gaps = 6/92 (6%) Query: 41 VYTVPVGSLTDTEIYTEHSHQTTVAKTSPSG---YYCASGDVHGNVRIWDTTQTTHILKT 97 Y + + E + HS SPS Y A+ V IW ++ + Sbjct: 238 RYDDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEK 297 Query: 98 ---TIPVFSGPVKDISWDSESKRIAAVGEGRE 126 T F SW +A G + Sbjct: 298 QPLTKEKFPDVCWRASWSLSGNVLAISGGDNK 329 Score = 43.3 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 14/81 (17%), Positives = 26/81 (32%), Gaps = 4/81 (4%) Query: 533 TFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNE 592 H + RLAT S D ++ ++ ++ + + H V V W + Sbjct: 66 NAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGP-VWQVAWAHP 124 Query: 593 T---TIVSAGQDSNIKFWNVP 610 + S D + W Sbjct: 125 KFGVILASCSYDGKVLIWKED 145 >5WLC-SG nrPDB Length = 573 Score = 112 bits (280), Expect = 4e-25, Method: Composition-based stats. Identities = 43/205 (20%), Positives = 76/205 (37%), Gaps = 15/205 (7%) Query: 403 SKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQF 462 +K S +P L + G + + G E+ VA S D ++ Sbjct: 197 TKYDITDFSKRPKKLKYAKGGAKYIPTSKHEYENTTEGHYDEI------LTVAASPDGKY 250 Query: 463 VAVGGQDSKVHVYKLSGASVSEVK-TIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVA 521 V GG+D K+ V+ S +V T E+ S+AF N L A+ K+ YS+ Sbjct: 251 VVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYASCADFKIRTYSIN 310 Query: 522 NNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAM 581 + H V +S + G+ D + ++W + P + + +G Sbjct: 311 Q---FSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWKI--PDETRLTFRGGDEP 365 Query: 582 SSVNSVIWLNETTIVSAGQDSNIKF 606 + W+ E G+D +K+ Sbjct: 366 QKLLRR-WMKEN--AKEGEDGEVKY 387 Score = 86.1 bits (211), Expect = 4e-17, Method: Composition-based stats. Identities = 52/324 (16%), Positives = 101/324 (31%), Gaps = 32/324 (9%) Query: 32 KIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQT 91 K++Y G + Y +P H + SP G Y +G + +W T Sbjct: 210 KLKYAKGGAKY-IPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESL 268 Query: 92 THILKTTIPVFSGPVKDISWDSESKRI-AAVGEGRERFGHVFLFDTGTSNGNLTGQARAM 150 + + G V +++ S ++ A+ + + R + F L G + Sbjct: 269 SPVKVIPTKDRRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLE---ILYGHHDIV 325 Query: 151 NSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGG 210 + + + G+ D T +++ P TF + +R A G Sbjct: 326 EDIS-ALAMERCVTVGARDRTAMLWKIPDETRL-TFRGGDEPQKLLR--RWMKENAKEGE 381 Query: 211 DGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT 270 DG + + D+S + + D + S + I +W++A Sbjct: 382 DGEVK------------YPDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSLAK 429 Query: 271 LKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITAL 330 K T + I + +S + + + + Q IT+L Sbjct: 430 KKPIFTERIAHGILPEP------SFNDISGETDEELRKRQLQGKKLLQPF-----WITSL 478 Query: 331 SSSADGKTLFSADAEGHINSWDIS 354 + S G + W IS Sbjct: 479 YAIPYSNVFISGSWSGSLKVWKIS 502 Score = 84.5 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 46/352 (13%), Positives = 97/352 (27%), Gaps = 63/352 (17%) Query: 234 KNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVG-TRIEDQQLGIIW 292 H + + SPDG + + D+ + +W+ +L K IP R E L Sbjct: 231 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRK 290 Query: 293 TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 L + A+ I + S ++ YGH+ + +S+ A + + + W Sbjct: 291 NSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWK 350 Query: 353 ISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSS 412 I + F + G D ++ S Sbjct: 351 I-PDETRLTFRGGDEPQKLL----------------RRWMKENAKEGEDGEVKYPDE-SE 392 Query: 413 QPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKV 472 PL +G I V + G + + Sbjct: 393 APLFFC---EGSIDVVSMVDDFH---------------------------FITGSDNGNI 422 Query: 473 HVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSW 532 ++ L+ + I H + + + + + ++ + +L Sbjct: 423 CLWSLAKKKPIFTERIAH-----GILPEPSFNDI-SGETDEELRKRQLQ-GKKLLQPF-- 473 Query: 533 TFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSV 584 + + P + +GS S+ VW ++ ++ V Sbjct: 474 -----WITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGV 520 Score = 82.2 bits (201), Expect = 6e-16, Method: Composition-based stats. Identities = 43/352 (12%), Positives = 107/352 (30%), Gaps = 73/352 (20%) Query: 178 PPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 ++++T H + +V +PDG + G D +++++ + V + Sbjct: 224 SKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRR--- 280 Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQAL 297 G V L + + ++ ++ AD I+ +++ + + I + Sbjct: 281 --GEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVED----------- 327 Query: 298 VSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGI 357 I+AL+ + + + W I Sbjct: 328 -----------------------------ISALAME---RCVTVGARDRTAMLWKI-PDE 354 Query: 358 SNRVFPDVHATMI----TGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQ 413 + F + +G+ V + D + G ++ + Sbjct: 355 TRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMVDDFH-- 412 Query: 414 PLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVH 473 + S +G+I + + K I++ I++ ND G D ++ Sbjct: 413 --FITGSDNGNICLWSLAKKKPIFTE------RIAHGILPEPSFND----ISGETDEELR 460 Query: 474 VYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFE 525 + K ++ P ITS+ ++ S + + +++N Sbjct: 461 ------KRQLQGKKLLQPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLR 506 Score = 78.0 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 23/124 (18%), Positives = 52/124 (41%), Gaps = 3/124 (2%) Query: 487 TIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP 546 T H EI +VA S +G ++V + RK+I +S + +V +++ Sbjct: 232 TEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTES-LSPVKVIPTKDRRGEVLSLAFRK 290 Query: 547 DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKF 606 ++ +L D + +++N+ S I+ + ++++ E + +D Sbjct: 291 NSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAM--ERCVTVGARDRTAML 348 Query: 607 WNVP 610 W +P Sbjct: 349 WKIP 352 Score = 53.7 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 17/80 (21%), Positives = 34/80 (42%) Query: 530 NSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW 589 N+ H ++ V+ SPD + TG D +IVW+ S +I ++ Sbjct: 230 NTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFR 289 Query: 590 LNETTIVSAGQDSNIKFWNV 609 N + ++ D I+ +++ Sbjct: 290 KNSDQLYASCADFKIRTYSI 309 Score = 44.9 bits (104), Expect = 9e-05, Method: Composition-based stats. Identities = 43/301 (14%), Positives = 81/301 (26%), Gaps = 52/301 (17%) Query: 3 EFSQTALFPSLPRTARGTAVVLGNTPAGDKI-QYCNGTSVYTVPVGSLTDTEIYTEHSHQ 61 S + P+ R RG + L D++ C + T + + EI H Sbjct: 267 SLSPVKVIPTKDR--RGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDI 324 Query: 62 TTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAV 121 G +W T + T P K + +R Sbjct: 325 VEDISALAMERCVTVGARDRTAMLWKIPDETRL---TFRGGDEPQKLL------RRWMKE 375 Query: 122 GEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFK 181 G V D S L +++ V F I+GSD+ + ++ K Sbjct: 376 NAKEGEDGEVKYPD--ESEAPLFFCEGSIDVVSMVDD--FHFITGSDNGNICLWSLAKKK 431 Query: 182 FKST---------------FGEHTK-----------------FVHSVRYNPDGSLFASTG 209 T T ++ S+ P ++F S Sbjct: 432 PIFTERIAHGILPEPSFNDISGETDEELRKRQLQGKKLLQPFWITSLYAIPYSNVFISGS 491 Query: 210 GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG----TKIASASADKTIKI 265 G++ ++ D ++ + + + G +AS + + + Sbjct: 492 WSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRLGR 551 Query: 266 W 266 W Sbjct: 552 W 552 >4J0X-A nrPDB Length = 451 Score = 112 bits (279), Expect = 5e-25, Method: Composition-based stats. Identities = 43/205 (20%), Positives = 76/205 (37%), Gaps = 15/205 (7%) Query: 403 SKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQF 462 +K S +P L + G + + G E+ VA S D ++ Sbjct: 75 TKYDITDFSKRPKKLKYAKGGAKYIPTSKHEYENTTEGHYDEI------LTVAASPDGKY 128 Query: 463 VAVGGQDSKVHVYKLSGASVSEVK-TIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVA 521 V GG+D K+ V+ S +V T E+ S+AF N L A+ K+ YS+ Sbjct: 129 VVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYASCADFKIRTYSIN 188 Query: 522 NNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAM 581 + H V +S + G+ D + ++W + P + + +G Sbjct: 189 Q---FSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWKI--PDETRLTFRGGDEP 243 Query: 582 SSVNSVIWLNETTIVSAGQDSNIKF 606 + W+ E G+D +K+ Sbjct: 244 QKLLRR-WMKEN--AKEGEDGEVKY 265 Score = 85.7 bits (210), Expect = 5e-17, Method: Composition-based stats. Identities = 52/324 (16%), Positives = 101/324 (31%), Gaps = 32/324 (9%) Query: 32 KIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQT 91 K++Y G + Y +P H + SP G Y +G + +W T Sbjct: 88 KLKYAKGGAKY-IPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESL 146 Query: 92 THILKTTIPVFSGPVKDISWDSESKRI-AAVGEGRERFGHVFLFDTGTSNGNLTGQARAM 150 + + G V +++ S ++ A+ + + R + F L G + Sbjct: 147 SPVKVIPTKDRRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLE---ILYGHHDIV 203 Query: 151 NSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGG 210 + + + G+ D T +++ P TF + +R A G Sbjct: 204 EDIS-ALAMERCVTVGARDRTAMLWKIPDETRL-TFRGGDEPQKLLR--RWMKENAKEGE 259 Query: 211 DGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT 270 DG + + D+S + + D + S + I +W++A Sbjct: 260 DGEVK------------YPDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSLAK 307 Query: 271 LKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITAL 330 K T + I + +S + + + + Q IT+L Sbjct: 308 KKPIFTERIAHGILPEP------SFNDISGETDEELRKRQLQGKKLLQPF-----WITSL 356 Query: 331 SSSADGKTLFSADAEGHINSWDIS 354 + S G + W IS Sbjct: 357 YAIPYSNVFISGSWSGSLKVWKIS 380 Score = 84.2 bits (206), Expect = 2e-16, Method: Composition-based stats. Identities = 46/352 (13%), Positives = 97/352 (27%), Gaps = 63/352 (17%) Query: 234 KNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVG-TRIEDQQLGIIW 292 H + + SPDG + + D+ + +W+ +L K IP R E L Sbjct: 109 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRK 168 Query: 293 TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 L + A+ I + S ++ YGH+ + +S+ A + + + W Sbjct: 169 NSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWK 228 Query: 353 ISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSS 412 I + F + G D ++ S Sbjct: 229 I-PDETRLTFRGGDEPQKLL----------------RRWMKENAKEGEDGEVKYPDE-SE 270 Query: 413 QPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKV 472 PL +G I V + G + + Sbjct: 271 APLFFC---EGSIDVVSMVDDFH---------------------------FITGSDNGNI 300 Query: 473 HVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSW 532 ++ L+ + I H + + + + + ++ + +L Sbjct: 301 CLWSLAKKKPIFTERIAH-----GILPEPSFNDI-SGETDEELRKRQLQ-GKKLLQPF-- 351 Query: 533 TFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSV 584 + + P + +GS S+ VW ++ ++ V Sbjct: 352 -----WITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGV 398 Score = 81.8 bits (200), Expect = 8e-16, Method: Composition-based stats. Identities = 43/352 (12%), Positives = 107/352 (30%), Gaps = 73/352 (20%) Query: 178 PPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 ++++T H + +V +PDG + G D +++++ + V + Sbjct: 102 SKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRR--- 158 Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQAL 297 G V L + + ++ ++ AD I+ +++ + + I + Sbjct: 159 --GEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVED----------- 205 Query: 298 VSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGI 357 I+AL+ + + + W I Sbjct: 206 -----------------------------ISALAME---RCVTVGARDRTAMLWKI-PDE 232 Query: 358 SNRVFPDVHATMI----TGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQ 413 + F + +G+ V + D + G ++ + Sbjct: 233 TRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMVDDFH-- 290 Query: 414 PLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVH 473 + S +G+I + + K I++ I++ ND G D ++ Sbjct: 291 --FITGSDNGNICLWSLAKKKPIFTE------RIAHGILPEPSFND----ISGETDEELR 338 Query: 474 VYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFE 525 + K ++ P ITS+ ++ S + + +++N Sbjct: 339 ------KRQLQGKKLLQPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLR 384 Score = 77.6 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 23/124 (18%), Positives = 52/124 (41%), Gaps = 3/124 (2%) Query: 487 TIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP 546 T H EI +VA S +G ++V + RK+I +S + +V +++ Sbjct: 110 TEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTES-LSPVKVIPTKDRRGEVLSLAFRK 168 Query: 547 DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKF 606 ++ +L D + +++N+ S I+ + ++++ E + +D Sbjct: 169 NSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAM--ERCVTVGARDRTAML 226 Query: 607 WNVP 610 W +P Sbjct: 227 WKIP 230 Score = 53.7 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 17/80 (21%), Positives = 34/80 (42%) Query: 530 NSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW 589 N+ H ++ V+ SPD + TG D +IVW+ S +I ++ Sbjct: 108 NTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFR 167 Query: 590 LNETTIVSAGQDSNIKFWNV 609 N + ++ D I+ +++ Sbjct: 168 KNSDQLYASCADFKIRTYSI 187 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 43/301 (14%), Positives = 81/301 (26%), Gaps = 52/301 (17%) Query: 3 EFSQTALFPSLPRTARGTAVVLGNTPAGDKI-QYCNGTSVYTVPVGSLTDTEIYTEHSHQ 61 S + P+ R RG + L D++ C + T + + EI H Sbjct: 145 SLSPVKVIPTKDR--RGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDI 202 Query: 62 TTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAV 121 G +W T + T P K + +R Sbjct: 203 VEDISALAMERCVTVGARDRTAMLWKIPDETRL---TFRGGDEPQKLL------RRWMKE 253 Query: 122 GEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFK 181 G V D S L +++ V F I+GSD+ + ++ K Sbjct: 254 NAKEGEDGEVKYPD--ESEAPLFFCEGSIDVVSMVDD--FHFITGSDNGNICLWSLAKKK 309 Query: 182 FKST---------------FGEHTK-----------------FVHSVRYNPDGSLFASTG 209 T T ++ S+ P ++F S Sbjct: 310 PIFTERIAHGILPEPSFNDISGETDEELRKRQLQGKKLLQPFWITSLYAIPYSNVFISGS 369 Query: 210 GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG----TKIASASADKTIKI 265 G++ ++ D ++ + + + G +AS + + + Sbjct: 370 WSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRLGR 429 Query: 266 W 266 W Sbjct: 430 W 430 >5MWJ-A nrPDB Length = 337 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 45/308 (14%), Positives = 98/308 (31%), Gaps = 34/308 (11%) Query: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKR 117 H S + +G G V++WD + P PV + + Sbjct: 50 HGEVVCAVTISNPTRHVYTGG-KGCVKVWDISH---------PGNKSPVSQLDCLNRDNY 99 Query: 118 IAAVG----------EGRERFGHVFLF--DTGTSNGNLTGQARAMNSVDFKPSRPFRIIS 165 I + G ++ T LT A A ++ P S Sbjct: 100 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCF-S 158 Query: 166 GSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKT 225 D +A+++ F HT + + DG+ + G D T+ ++ +G + Sbjct: 159 CCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQ- 217 Query: 226 GVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIED 285 L+ + +F L + P G +A +++ +V + + + Sbjct: 218 -------LQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVL- 269 Query: 286 QQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAE 345 L + + VS + +N G+ + + ++ + S D K + + + Sbjct: 270 -SLKFAYCGKWFVSTGKDNLLNAWRTPYGA-SIFQSKESSSVLSCDISVDDKYIVTGSGD 327 Query: 346 GHINSWDI 353 +++ Sbjct: 328 KKATVYEV 335 Score = 108 bits (269), Expect = 9e-24, Method: Composition-based stats. Identities = 44/295 (14%), Positives = 94/295 (31%), Gaps = 13/295 (4%) Query: 188 EHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW 247 H + V +V + + G G + +++ L + + Sbjct: 49 NHGEVVCAVTISNPTRHVYTGGK-GCVKVWDIS--HPGNKSPVSQLDCLNRDNYIRSCKL 105 Query: 248 SPDGTKIASASADKTIKIWNVATLKVE-KTIPVGTRIEDQQLGIIWTKQALVSISANGFI 306 PDG + T+ IW++A K + L I + S ++G I Sbjct: 106 LPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNI 165 Query: 307 NFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVH 366 + ++ + GH + + S DG L++ + + SWD+ G + Sbjct: 166 AVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ--QHDF 223 Query: 367 ATMITGIKTTSKGDLFTVSWDDHLKVV----PAGGSGVDSSKAVANKLSSQPLGLAVSAD 422 + I + G+ V + V + ++ L G + Sbjct: 224 TSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVST 283 Query: 423 GDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKL 477 G + ++ + + S + +S D +++ G D K VY++ Sbjct: 284 GKDNLLNAWRTPY---GASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEV 335 Score = 88.4 bits (217), Expect = 8e-18, Method: Composition-based stats. Identities = 52/297 (17%), Positives = 104/297 (35%), Gaps = 19/297 (6%) Query: 322 GHNKAITALSSSADGKTLFSADAEGHINSWDIS----TGISNRVFPDVHATMITGIKTTS 377 H + + A++ S + +++ G + WDIS +++ I K Sbjct: 49 NHGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLP 107 Query: 378 KGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAAC-YKHIAI 436 G V + + + KA + LA+S D + + C +IA+ Sbjct: 108 DGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAV 167 Query: 437 YSHGKLTEV----PISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPA 492 + T V + +SC+ +SND + GG D+ V + L + + Sbjct: 168 WDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDF--TS 225 Query: 493 EITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLA 552 +I S+ + G +L +S V V + H + V + ++ Sbjct: 226 QIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDK----YQLHLHESCVLSLKFAYCGKWFV 281 Query: 553 TGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 + DN + W I + + S ++ I +++ IV+ D + V Sbjct: 282 STGKDNLLNAWRTP---YGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEV 335 Score = 71.1 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 31/179 (17%), Positives = 68/179 (37%), Gaps = 9/179 (5%) Query: 436 IYSHGKLTEVPISYNSSC-VALSNDKQFVAVGGQDSKVHVYKL----SGASVSEVKTIVH 490 I H + C V +SN + V GG V V+ + + + VS++ + Sbjct: 38 IPRHARQINTLNHGEVVCAVTISNPTRHVYTGG-KGCVKVWDISHPGNKSPVSQLDCLNR 96 Query: 491 PAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVR 550 I S +G L+ ++ + + +A T ++ SPD+ Sbjct: 97 DNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAE-LTSSAPACYALAISPDSKV 155 Query: 551 LATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 + D ++ VW+++ + S ++ I + T + + G D+ ++ W++ Sbjct: 156 CFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCID--ISNDGTKLWTGGLDNTVRSWDL 212 Score = 66.0 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 37/225 (16%), Positives = 66/225 (29%), Gaps = 15/225 (6%) Query: 2 SEFSQTALFPSLPR------TARGTAVVLGNTPAGDKIQYCNGTSVYTV-PVGSLTDTEI 54 S S L PR ++ L +P C V + + T Sbjct: 119 STLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQ 178 Query: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSE 114 + H+ + S G +G + VR WD + + + F+ + + + Sbjct: 179 FQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ---HDFTSQIFSLGYCPT 235 Query: 115 SKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAI 174 + +A G E L L + S+ F + +S DN + Sbjct: 236 GEWLAV---GMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKW-FVSTGKDNLLNA 291 Query: 175 FEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNG 219 + P E + V S + D + GD +Y Sbjct: 292 WRTPYGASIFQSKE-SSSVLSCDISVDDKYIVTGSGDKKATVYEV 335 >5WYJ-BE nrPDB Length = 939 Score = 108 bits (270), Expect = 5e-24, Method: Composition-based stats. Identities = 70/447 (15%), Positives = 140/447 (31%), Gaps = 59/447 (13%) Query: 10 FPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSP 69 SL G++ + T +GD I Y + V E Y T A Sbjct: 251 ISSLSFRTDGSSHLSVGTSSGDLIFYD-LDRRSRIHVLKNIHRESYGG----VTQATFLN 305 Query: 70 SGYYCASGDVHGNVRIW-----------DTTQTTHILKTTIPVFSGPVKDISW-DSESKR 117 + +++ + D + S P I++ DS+S Sbjct: 306 GQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHF 365 Query: 118 IAAVGEGRERFGHVFLFDTGTSNGNLTGQAR----------------AMNSVDFKPSRP- 160 + + + R + D + + + + ++ + +R Sbjct: 366 MLSASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAIENARIG 425 Query: 161 --FRIISGSDDNTV-AIFEGPPFKFKS-TFGEHTK-FVHSVRYNPDGSLFASTGGDGTIV 215 II+ D ++ + TF FV SV + G+ +G+I Sbjct: 426 EWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSIT 485 Query: 216 LYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEK 275 +YN G ++ H +V G++ K+ S D + ++ + Sbjct: 486 IYNMQSGILRKKYKL-------HKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLG 538 Query: 276 TIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSAD 335 + + I + + + I ++ + + +GH+ ITA S + Sbjct: 539 KLKLDAPITA--MVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPE 596 Query: 336 GKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVS---------W 386 G+ + SA + I +WD+ TG + T +K + GDL + W Sbjct: 597 GRWIVSASLDSTIRTWDLPTGGCIDGIIVD--NVATNVKFSPNGDLLATTHVTGNGICIW 654 Query: 387 DDHLKVVPAGGSGVDSSKAVANKLSSQ 413 + + +D S+ L S Sbjct: 655 TNRAQFKTVSTRTIDESEFARMALPST 681 Score = 103 bits (256), Expect = 3e-22, Method: Composition-based stats. Identities = 78/556 (14%), Positives = 162/556 (29%), Gaps = 98/556 (17%) Query: 29 AGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDT 88 +K+ ++V V + E Q T A+ +P A G V G V +++ Sbjct: 176 YLNKLTVVTKSNVLLFNVRTGKLVFTSNEFPDQITTAEPAPVLDIIALGTVTGEVIMFNM 235 Query: 89 TQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTG-QA 147 + I TI + + +S+ ++ +VG + D + L Sbjct: 236 RKGKRI--RTIKIPQSRISSLSFRTDGSSHLSVGTSSG-DLIFYDLDRRSRIHVLKNIHR 292 Query: 148 ---RAMNSVDFKPSRPFRIISGSDDNTVA--IFE-----------GPPFKFKSTFGEHTK 191 + F +P + SG DN++ +F+ P ++ + G H++ Sbjct: 293 ESYGGVTQATFLNGQPIIVTSGG-DNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQ 351 Query: 192 FVHSVRYNPDGS-LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD 250 + + S S D + L++ + + + H D Sbjct: 352 PPSYIAFADSQSHFMLSASKDRS--LWSF---SLRKDAQSQEMSQRLHKK--------QD 398 Query: 251 GTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVN 310 G V ++ P + + I + + + F + Sbjct: 399 GG--------------RVGGSTIKSKFPEIVALAIENARIGEWENIITAHKDEKFARTWD 444 Query: 311 PELGSI--DQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHAT 368 + + + +++ S G F + G I +++ +GI R +H Sbjct: 445 MRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNMQSGI-LRKKYKLHKR 503 Query: 369 MITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVA 428 +TGI + K+V G G+ + + Sbjct: 504 AVTGISLDG----------MNRKMVSCGLDGIVG---------------FYDFNKSTLLG 538 Query: 429 ACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTI 488 I + + A+ D + V V Sbjct: 539 KLKLDAPI---------------TAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLW- 582 Query: 489 VHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDN 548 H IT+ FS G ++V+ + + + + T V +SP+ Sbjct: 583 GHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGIIVDNVATN----VKFSPNG 638 Query: 549 VRLATGSLDNS-VIVW 563 LAT + + + +W Sbjct: 639 DLLATTHVTGNGICIW 654 Score = 97.2 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 71/550 (12%), Positives = 166/550 (30%), Gaps = 69/550 (12%) Query: 71 GYYCASGDVHGNVRIW------DTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEG 124 G Y + ++ I+ D + K T+ G + +S + + + Sbjct: 125 GDYLCASTDDNSIFIYKKSDPQDKYPSEFYTKLTVTEIQGG-EIVSLQHLATYLNKLTVV 183 Query: 125 RERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKS 184 + +F TG + + + P I G+ V +F K Sbjct: 184 TKSNVLLFNVRTGKLVFTSNEFPDQITTAEPAPVL-DIIALGTVTGEVIMFNMRKGKRIR 242 Query: 185 TFGEHTKFVHSVRYNPDGS-LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVF 243 T + S+ + DGS + G ++ Y+ ++ V ++ ++ V Sbjct: 243 TIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDLDRRSRIHVLKNIHRESYG---GVT 299 Query: 244 GLTWSPDGTKIASASADKTIK--IWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSIS 301 T+ I ++ D ++K +++ +L S Sbjct: 300 QATFLNGQPIIVTSGGDNSLKEYVFD---------------------------PSLSQGS 332 Query: 302 ANGFINFVNPELGSIDQVRYGHNKAITALSS-SADGKTLFSADAEGHINSWDISTGISNR 360 + V + + R GH++ + ++ + + SA + + S+ + ++ Sbjct: 333 GD-----VVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQ 387 Query: 361 VFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVS 420 G + + + + + ++ ++ Sbjct: 388 EMSQRLHKKQDGGRVGG-------------STIKSKFPEIVALAIENARIGE--WENIIT 432 Query: 421 ADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGA 480 A D A + + VA+S F +G + + +Y + Sbjct: 433 AHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNMQSG 492 Query: 481 SVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVA 540 + K +H +T ++ +V+ V Y + L A + Sbjct: 493 -ILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKL----DAPIT 547 Query: 541 CVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQ 600 + + + A D S++V ++ + + H+ IVSA Sbjct: 548 AMVYHRSSDLFALALDDLSIVV--IDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASL 605 Query: 601 DSNIKFWNVP 610 DS I+ W++P Sbjct: 606 DSTIRTWDLP 615 >4U1E-I nrPDB Length = 347 Score = 106 bits (264), Expect = 3e-23, Method: Composition-based stats. Identities = 48/352 (13%), Positives = 103/352 (29%), Gaps = 56/352 (15%) Query: 142 NLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPD 201 LTG R + V + + S S D++ +++ + T HT + S+ + Sbjct: 5 KLTGHERPLTQVKYNKEGDL-LFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCF 63 Query: 202 GSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADK 261 + D +I L++ +G ++ V + +SP G A D Sbjct: 64 TKYCVTGSADYSIKLWDVSNGQCVATWKSPV--------PVKRVEFSPCGNYFL-AILDN 114 Query: 262 ------TIKIWNVATLKVEKTIPVGTRIEDQQL------------GIIWTKQALVSISAN 303 +I I+ + + + ++ G + +++ + Sbjct: 115 VMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKD 174 Query: 304 GFINFVNPELG-SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVF 362 G I+ + H K+I+ + S D ++ + + D+ST +V Sbjct: 175 GKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVST---LQVL 231 Query: 363 PDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSAD 422 + LK G G ++ + Sbjct: 232 KKYETDCPLNTAVITP-----------LKEFIILGGGQEAKDVTTTSANEGKFEARF--- 277 Query: 423 GDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHV 474 + I+ + VA+S A GG+D + + Sbjct: 278 ----------YHKIFEEEIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIRL 319 Score = 98.0 bits (242), Expect = 1e-20, Method: Composition-based stats. Identities = 48/328 (14%), Positives = 94/328 (28%), Gaps = 44/328 (13%) Query: 54 IYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS 113 T H T K + G S + +W + + T+ +G + I D Sbjct: 5 KLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLG--TLDGHTGTIWSIDVDC 62 Query: 114 ESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRII----SGSDD 169 +K V + ++ G + V+F P + + + Sbjct: 63 FTKY--CVTGSADYSIKLWDVSNGQCVATWKS-PVPVKRVEFSPCGNYFLAILDNVMKNP 119 Query: 170 NTVAIFEGP-----------PFKFKSTFGEHT--KFVHSVRYNPDGSLFASTGGDGTIVL 216 ++ I+E + H ++ G + DG I Sbjct: 120 GSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISK 179 Query: 217 YNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKT 276 Y+ + + H S+ + +SPD T ++S D + +V+TL+V K Sbjct: 180 YDVSNN------YEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKK 233 Query: 277 IPVGTRIEDQQLGIIWTKQALVSISANGF--------------INFVNPELGSIDQVRYG 322 + I K+ ++ F + G Sbjct: 234 YETDCPLNTAV--ITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQG 291 Query: 323 HNKAITALSSSADGKTLFSADAEGHINS 350 H + ++ S G + S +G I Sbjct: 292 HFGPLNTVAISPQGTSYASGGEDGFIRL 319 Score = 95.3 bits (235), Expect = 7e-20, Method: Composition-based stats. Identities = 44/339 (12%), Positives = 89/339 (26%), Gaps = 81/339 (23%) Query: 279 VGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKT 338 G Q+ L S S + + G GH I ++ K Sbjct: 7 TGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFTKY 66 Query: 339 LFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLK---VVPA 395 + A+ I WD+S G + + ++ + G+ F D+ +K + Sbjct: 67 CVTGSADYSIKLWDVSNGQCVATWKSP--VPVKRVEFSPCGNYFLAILDNVMKNPGSINI 124 Query: 396 GGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVA 455 DS+ K+S +P+ K+ ++ Sbjct: 125 YEIERDSATHELTKVSEEPI------------------------HKIITHEGLDAATVAG 160 Query: 456 LSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKV 515 S +++ G +D K+ Y +S +H I+ + FS + + + + + Sbjct: 161 WSTKGKYIIAGHKDGKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNS 220 Query: 516 IPYSVA----------------------------------------------------NN 523 V+ + Sbjct: 221 FLVDVSTLQVLKKYETDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHK 280 Query: 524 FELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIV 562 H + V+ SP A+G D + + Sbjct: 281 IFEEEIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIRL 319 Score = 54.9 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 15/84 (17%), Positives = 30/84 (35%), Gaps = 3/84 (3%) Query: 485 VKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSW 544 +K H +T V ++ G L + + + N + HT + + Sbjct: 4 IKLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNG---ERLGTLDGHTGTIWSIDV 60 Query: 545 SPDNVRLATGSLDNSVIVWNMNKP 568 TGS D S+ +W+++ Sbjct: 61 DCFTKYCVTGSADYSIKLWDVSNG 84 Score = 53.0 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 16/79 (20%), Positives = 30/79 (37%), Gaps = 2/79 (2%) Query: 531 SWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWL 590 T H + V ++ + L + S D+S VW + + S++ + Sbjct: 5 KLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFT 64 Query: 591 NETTIVSAGQDSNIKFWNV 609 V+ D +IK W+V Sbjct: 65 KYC--VTGSADYSIKLWDV 81 Score = 30.6 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 9/37 (24%), Positives = 12/37 (32%) Query: 49 LTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRI 85 + H SP G ASG G +R+ Sbjct: 283 EEEIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIRL 319 >5K19-A nrPDB Length = 569 Score = 105 bits (262), Expect = 6e-23, Method: Composition-based stats. Identities = 42/176 (23%), Positives = 68/176 (38%), Gaps = 7/176 (3%) Query: 425 IAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSE 484 + + + + +H + +C + Q + G + VH K Sbjct: 155 VKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQG-ESFAVHTCKSKSTRNPL 213 Query: 485 VKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSW 544 +K V + AFS +G FL Q + ++ ++ EL T F + CV W Sbjct: 214 LKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNF-DSVELHGTMKSYF--GGLLCVCW 270 Query: 545 SPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQ 600 SPD + TG D+ V VW+ D +I +G S V+ V + TT V G Sbjct: 271 SPDGKYIVTGGEDDLVTVWSF---VDCRVIARGHGHKSWVSVVAFDPYTTSVEEGD 323 Score = 72.2 bits (175), Expect = 6e-13, Method: Composition-based stats. Identities = 34/262 (12%), Positives = 73/262 (27%), Gaps = 34/262 (12%) Query: 60 HQTTVAKTSP-SGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRI 118 + T K P S GN+ +++ T + + + + + Sbjct: 150 SRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQG-ESFAVHTCKSK- 207 Query: 119 AAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP 178 T T A+N F P F + S D + +F Sbjct: 208 ----------------STRNPLLKWTVGEGALNEFAFSPDGKF-LACVSQDGFLRVFNFD 250 Query: 179 PFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAH 238 + T + + V ++PDG + G D + +++ VD + H Sbjct: 251 SVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIA-------RGHGH 303 Query: 239 SGSVFGLTWSPDGTKI-------ASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGII 291 V + + P T + S S + + + + T ++ + Sbjct: 304 KSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPV 363 Query: 292 WTKQALVSISANGFINFVNPEL 313 S+ + + + Sbjct: 364 SVTYRFGSVGQDTQLCLWDLTE 385 Score = 61.8 bits (148), Expect = 8e-10, Method: Composition-based stats. Identities = 41/274 (14%), Positives = 83/274 (30%), Gaps = 50/274 (18%) Query: 147 ARAMNSVDFKPSRPFRIISGSDDNTVAIFEG--------PPFKFKS---TFGEHT----- 190 + V + P + + ++ P ++ +F HT Sbjct: 149 KSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKS 208 Query: 191 ------------KFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAH 238 ++ ++PDG A DG + ++N G + Sbjct: 209 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYF------ 262 Query: 239 SGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALV 298 G + + WSPDG I + D + +W+ + I G + + ++ Sbjct: 263 -GGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDC---RVIARGHGHK-SWVSVVAFDPYTT 317 Query: 299 SISANGFINFVNPELGSIDQVRYGH---NKAITALSS--SADGKTLF------SADAEGH 347 S+ + F + D + +G N + LS S D + + S + Sbjct: 318 SVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQ 377 Query: 348 INSWDISTGISNRVFPDVHATMITGIKTTSKGDL 381 + WD++ I P A T + + Sbjct: 378 LCLWDLTEDILFPHQPLSRARTHTNVMNATSPPA 411 Score = 57.2 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 31/194 (15%), Positives = 64/194 (32%), Gaps = 33/194 (17%) Query: 444 EVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVH---PAEITSVAFS 500 P ++ + + + + + VG +V + S++ + +T V + Sbjct: 99 TQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWV 158 Query: 501 N-NGAFLVATDQSRKVIPYSVANNFE--------LAHTNSWTFHT--------------- 536 + + + S + Y+V + L S+ HT Sbjct: 159 PGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTV 218 Query: 537 --AKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW-LNET 593 + ++SPD LA S D + V+N + H + + V W + Sbjct: 219 GEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTM---KSYFGGLLCVCWSPDGK 275 Query: 594 TIVSAGQDSNIKFW 607 IV+ G+D + W Sbjct: 276 YIVTGGEDDLVTVW 289 Score = 55.6 bits (132), Expect = 6e-08, Method: Composition-based stats. Identities = 44/333 (13%), Positives = 105/333 (31%), Gaps = 41/333 (12%) Query: 281 TRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHN----KAITALSSSADG 336 T + L +L+ + G + ++P ++ +T + Sbjct: 102 TCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGS 161 Query: 337 KTLF-SADAEGHINSWDI-----STGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHL 390 ++LF A + G++ +++ +T ++ + + K+ S + Sbjct: 162 ESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLK------ 215 Query: 391 KVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYN 450 V G + VS DG + V + HG + Sbjct: 216 WTVGEGALNEFAFSP------DGKFLACVSQDGFLRVFNFDS---VELHGTMKSYF--GG 264 Query: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSN--------N 502 CV S D +++ GG+D V V+ V + H + ++ VAF + Sbjct: 265 LLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIA-RGHGHKSWVSVVAFDPYTTSVEEGD 323 Query: 503 GAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIV 562 +D+ + + + + + ++ VS R + D + + Sbjct: 324 PMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSV---TYRFGSVGQDTQLCL 380 Query: 563 WNMNKPS--DHPIIIKGAHAMSSVNSVIWLNET 593 W++ + H + + + +N+ + Sbjct: 381 WDLTEDILFPHQPLSRARTHTNVMNATSPPAGS 413 >5K0Y-T nrPDB Length = 329 Score = 105 bits (261), Expect = 7e-23, Method: Composition-based stats. Identities = 44/342 (12%), Positives = 105/342 (30%), Gaps = 46/342 (13%) Query: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDG 202 L G R++ + + + + + D V ++ + T+ HT V V + D Sbjct: 6 LQGHERSITQIKYN-REGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64 Query: 203 SLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKT 262 + D + L++ G + + + +S +V + G I ++ + Sbjct: 65 KHVLTGSADNSCRLWDCETGKQLALLKTNS--------AVRTCGFDFGGNIIMFSTDKQM 116 Query: 263 -----IKIWNVATLKVEKTIPVGTRIEDQQLGII-----WTKQALVSISANGFINFVNPE 312 + +++ +I I + +++ +G +N + + Sbjct: 117 GYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAK 176 Query: 313 LGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITG 372 G + H++ I + S + +A + +D +T + F Sbjct: 177 SGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFR--------- 227 Query: 373 IKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYK 432 T ++ VV GG + ++ A + Sbjct: 228 ---TEPPRELAALSPNYEHVVVGGGQEAMDVTTTSTRIGKFE-------------ARFFH 271 Query: 433 HIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHV 474 G++ + VA D + + GG+D V + Sbjct: 272 LAFEEEFGRVK--GHFGPINSVAFHPDGKSYSSGGEDGYVRI 311 Score = 99 bits (247), Expect = 3e-21, Method: Composition-based stats. Identities = 40/337 (11%), Positives = 95/337 (28%), Gaps = 51/337 (15%) Query: 24 LGNTPAGDKIQYCNGTSVYTVPVGSLTD-TEIYTEHSHQTTVAKTSPSGYYCASGDVHGN 82 + GD + + V + Y H+ + +G + Sbjct: 16 IKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNS 75 Query: 83 VRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLF-------- 134 R+WD + + + V+ +D I + + + F Sbjct: 76 CRLWDCETGKQL---ALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQ 132 Query: 135 -DTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFV 193 D + + S + P II+G + + + + EH++ + Sbjct: 133 IDNNEPYMKIPCNDSKITSAVWGPLGE-CIIAGHESGELNQYSAKSGEVLVNVKEHSRQI 191 Query: 194 HSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTK 253 + ++ + + ++F + D T L++ F + + +A SP+ Sbjct: 192 NDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRELA--------ALSPNYEH 243 Query: 254 IASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPEL 313 + + + + T + A F + Sbjct: 244 VVVGGG-------------------------QEAMDVTTTSTRIGKFEA----RFFHLAF 274 Query: 314 GSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINS 350 GH I +++ DGK+ S +G++ Sbjct: 275 EEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311 Score = 95.3 bits (235), Expect = 7e-20, Method: Composition-based stats. Identities = 42/311 (13%), Positives = 84/311 (27%), Gaps = 29/311 (9%) Query: 277 IPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADG 336 + G Q+ L +++ + +N G GH A+ + + D Sbjct: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64 Query: 337 KTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAG 396 K + + A+ WD TG + + + G++ S D + Sbjct: 65 KHVLTGSADNSCRLWDCETGKQLALLKT--NSAVRTCGFDFGGNIIMFSTDKQMGYQCFV 122 Query: 397 GSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSH--GKLTEVP-------- 446 + + + AV I H G+L + Sbjct: 123 SFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLV 182 Query: 447 ----ISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNN 502 S + + LS + +D+ ++ + + P E+ A S N Sbjct: 183 NVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRELA--ALSPN 240 Query: 503 GAFLVATD-------QSRKVIPYSVANNF----ELAHTNSWTFHTAKVACVSWSPDNVRL 551 +V + F H + V++ PD Sbjct: 241 YEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSY 300 Query: 552 ATGSLDNSVIV 562 ++G D V + Sbjct: 301 SSGGEDGYVRI 311 Score = 52.2 bits (123), Expect = 6e-07, Method: Composition-based stats. Identities = 20/82 (24%), Positives = 31/82 (37%), Gaps = 3/82 (3%) Query: 484 EVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVS 543 + H IT + ++ G L + V + N ++ HT V CV Sbjct: 3 PILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNG---ERLGTYMGHTGAVWCVD 59 Query: 544 WSPDNVRLATGSLDNSVIVWNM 565 D + TGS DNS +W+ Sbjct: 60 ADWDTKHVLTGSADNSCRLWDC 81 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 10/81 (12%), Positives = 27/81 (33%), Gaps = 2/81 (2%) Query: 528 HTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSV 587 H + + ++ + L T + D V VW + + H + Sbjct: 2 RPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVW--YSVNGERLGTYMGHTGAVWCVD 59 Query: 588 IWLNETTIVSAGQDSNIKFWN 608 + +++ D++ + W+ Sbjct: 60 ADWDTKHVLTGSADNSCRLWD 80 >3BG0-A nrPDB Length = 316 Score = 104 bits (260), Expect = 8e-23, Method: Composition-based stats. Identities = 58/285 (20%), Positives = 95/285 (33%), Gaps = 36/285 (12%) Query: 56 TEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS-- 113 T H A+ G A+ +V+I+D IL + GPV ++W Sbjct: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 Query: 114 ESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKP-SRPFRIISGSDDNTV 172 +A+ R+ T + G ++NSV + P + GS D + Sbjct: 70 YGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 Query: 173 AIFEGP---PFKFKSTFGEHTKFVHSVRY-----------NPDG------SLFASTGGDG 212 ++ ++ K HT ++V + +P G FAS G D Sbjct: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDN 189 Query: 213 TIVLY-NGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD----GTKIASASADKTIKIWN 267 I L+ DG + K AHS V + W+P + IAS S D + IW Sbjct: 190 LIKLWKEEEDGQW-----KEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT 244 Query: 268 VATLKVEKTIP-VGTRIEDQQLGIIWT--KQALVSISANGFINFV 309 P + + D + W+ L + + Sbjct: 245 CDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 Score = 99.6 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 59/311 (18%), Positives = 97/311 (31%), Gaps = 40/311 (12%) Query: 93 HILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTG--TSNGNLTGQARAM 150 ++ T + D D R+A R +F G +L G + Sbjct: 3 SVINTVDTSHEDMIHDAQMDYYGTRLATCSSD--RSVKIFDVRNGGQILIADLRGHEGPV 60 Query: 151 NSVDF-KPSRPFRIISGSDDNTVAIFEGPPFKFKSTFG--EHTKFVHSVRYNPD--GSLF 205 V + P + S S D V I+ ++ + H V+SV + P G + Sbjct: 61 WQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLIL 120 Query: 206 ASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW-----------SPDGTK- 253 A DG I L + T G +E + N AH+ ++W P G K Sbjct: 121 ACGSSDGAISL---LTYTGEGQWEVKKINN-AHTIGCNAVSWAPAVVPGSLIDHPSGQKP 176 Query: 254 -----IASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK------QALVSISA 302 AS D IK+W K D + W + S S Sbjct: 177 NYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQ 236 Query: 303 NGFINFVNPELGSID----QVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGIS 358 +G + + S + ++ + N + +S S L + + + W S Sbjct: 237 DGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQ 296 Query: 359 NRVFPDVHATM 369 DV+ Sbjct: 297 WVCISDVNKGQ 307 Score = 99.2 bits (245), Expect = 5e-21, Method: Composition-based stats. Identities = 46/290 (15%), Positives = 81/290 (27%), Gaps = 34/290 (11%) Query: 29 AGDKIQYCNGTSV---YTVPVGSLTDTEIYTEHSHQTTVAKTSPS--GYYCASGDVHGNV 83 G ++ C+ + V G H + G AS V Sbjct: 24 YGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKV 83 Query: 84 RIWDTTQTTHILKTTIPVFSGPVKDISWDS-ESKRIAAVGEGRERFGHVFLFDTG--TSN 140 IW T V + W + I A G + G Sbjct: 84 IIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 143 Query: 141 GNLTGQARAMNSVDF----------------KPSRPFRIISGSDDNTVAIFEGPP---FK 181 N+V + KP+ R SG DN + +++ +K Sbjct: 144 KINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWK 203 Query: 182 FKSTFGEHTKFVHSVRYNPD----GSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 + H+ +V V + P S AS DG + ++ D + K Sbjct: 204 EEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKF-- 261 Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQ 287 + V+ ++WS +A + D + +W + I + + Sbjct: 262 -NDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSV 310 Score = 71.8 bits (174), Expect = 9e-13, Method: Composition-based stats. Identities = 50/310 (16%), Positives = 97/310 (31%), Gaps = 37/310 (11%) Query: 316 IDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVF-PDVHATMITGIK 374 I+ V H I G L + ++ + +D+ G + H + + Sbjct: 5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVA 64 Query: 375 TTSK--GDLFTVSWDDHLKVVPAGGSGV-DSSKAVANKLSSQPLGLAVSADGDIAVAACY 431 G++ D ++ +G + S A SS D + +A Sbjct: 65 WAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGS 124 Query: 432 KHIAI-------YSHGKLTEVPISYNSSCVALS-------------NDK------QFVAV 465 AI ++ ++ ++ C A+S + A Sbjct: 125 SDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFAS 184 Query: 466 GGQDSKVHVYKLS--GASVSEVKTIVHPAEITSVAFSNN----GAFLVATDQSRKVIPYS 519 GG D+ + ++K G E K H + VA++ + + + + Q +V ++ Sbjct: 185 GGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT 244 Query: 520 VAN-NFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGA 578 + + V VSWS LA DN V +W + I Sbjct: 245 CDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVN 304 Query: 579 HAMSSVNSVI 588 SV++ + Sbjct: 305 KGQGSVSASV 314 Score = 66.8 bits (161), Expect = 3e-11, Method: Composition-based stats. Identities = 32/172 (18%), Positives = 53/172 (30%), Gaps = 24/172 (13%) Query: 460 KQFVAVGGQDSKVHVYKLSGASVSEVKTI-VHPAEITSVAF-SNN-GAFLVATDQSRKVI 516 +A D V ++ + + + H + VA+ G L + RKVI Sbjct: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84 Query: 517 PYSVANNFELAHTNSWTFHTAKVACVSWSPD--NVRLATGSLDNSVIVWNMNKPSDHPII 574 + N ++ H + V V W+P + LA GS D ++ + + Sbjct: 85 IWREENG-TWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 143 Query: 575 IKGAHAMSSVNSVIWLNE------------------TTIVSAGQDSNIKFWN 608 N+V W S G D+ IK W Sbjct: 144 KINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWK 195 Score = 63.7 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 33/176 (18%), Positives = 55/176 (31%), Gaps = 25/176 (14%) Query: 460 KQFVAVGGQDSKVHVYKLSGAS-VSEVKTIVHPAEITSVAFSNN--GAFLVATDQSRKVI 516 +A D KV +++ + + H + + SV ++ + G L + Sbjct: 71 GNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 Query: 517 PYSVANNFELAHTNSWTFHTAKVACVSWSP--------DN---------VRLATGSLDNS 559 + + HT VSW+P D+ R A+G DN Sbjct: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNL 190 Query: 560 VIVWNMNKPSDHPIIIKGAHAMSSVNSVIW-----LNETTIVSAGQDSNIKFWNVP 610 + +W + K V V W L +TI S QD + W Sbjct: 191 IKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 >5WLC-LN nrPDB Length = 776 Score = 102 bits (253), Expect = 6e-22, Method: Composition-based stats. Identities = 62/404 (15%), Positives = 138/404 (34%), Gaps = 45/404 (11%) Query: 104 GPVKDISWDSESK-RIAAVGEGRERFGH----VFLFDTGTS----NGNLTGQARAMNSVD 154 + +++ +S + R G + +++ + G+ R++ + Sbjct: 44 ATITSLAFSHKSNINKLTPSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLC 103 Query: 155 FKPSRP--FRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDG 212 + R+ S V ++ + ++ + S+ N + +G Sbjct: 104 WSNVNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNG 163 Query: 213 TIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIW-----N 267 T+VL + G GV E D++ + V L W D + +D I+IW + Sbjct: 164 TVVLIDISGG--PGVLEHDTI-LMRQEARVLTLAWKKDD-FVIGGCSDGRIRIWSAQKND 219 Query: 268 VATLKVEKTIPVGTRIEDQQLGII----WTKQALVSISANGFINFVNPELGSIDQVRYGH 323 ++ T+ V ++ L + S + G I F + + +++Q H Sbjct: 220 ENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAH 279 Query: 324 NKAITALSSSADGKTLFSADAEGHINSWDISTGISNR-------VFPDVHATMITGIKT- 375 + + L++ D +FSA + I + +T S + +H I I Sbjct: 280 DADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAY 339 Query: 376 -TSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHI 434 + D + V+ + S + + + + V+ + + V+ + Sbjct: 340 QSKGADFLVSGGVEKTLVINSLTSFSNGNYRKMPTVEPYSKNVLVNKEQRLVVSWSESTV 399 Query: 435 AIYSHGKLTEVPISYNSSC------------VALSNDKQFVAVG 466 I++ G + +Y C +LS D Q + VG Sbjct: 400 KIWTMGTDSSTEQNYKLVCKLTLKDDQNISTCSLSPDGQVLVVG 443 Score = 91.1 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 85/604 (14%), Positives = 178/604 (29%), Gaps = 82/604 (13%) Query: 59 SHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISW-DSESKR 117 SH++ + K +PS A G +GN+ IW+ ++ + W + + Sbjct: 52 SHKSNINKLTPSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCWSNVNGES 111 Query: 118 IAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEG 177 + G + TG N + + S+ ++ G D+ TV + + Sbjct: 112 LRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISIN-DSQDKLSVGCDNGTVVLIDI 170 Query: 178 PPF----KFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSL 233 + + V ++ + D DG I +++ D+++ Sbjct: 171 SGGPGVLEHDTILMRQEARVLTLAWKKD-DFVIGGCSDGRIRIWSAQKN-------DENM 222 Query: 234 KNVAHSGSV------FGLTWS----PDGTKIASASADKTIKIWNVATLKVEKTIPVGTRI 283 + H+ V L WS P +IAS + +IK W+ + ++ Sbjct: 223 GRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKA-HDA 281 Query: 284 EDQQLGIIWTKQALVSISANGFINFVNPELGSIDQ----------VRYGHNKAITALSSS 333 + L + S + I + + + +G++ S Sbjct: 282 DVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQS 341 Query: 334 ADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVV 393 L S E + +++ + + +K VSW + + Sbjct: 342 KGADFLVSGGVEKTLVINSLTSFSNGNYRKMPTVEPYSKNVLVNKEQRLVVSWSESTVKI 401 Query: 394 PAGGSGVDSSK------AVANKLSSQPLGLAVSADGDIAVAA---CYKHIAIYSHGKLTE 444 G+ + + + K ++S DG + V K + G + Sbjct: 402 WTMGTDSSTEQNYKLVCKLTLKDDQNISTCSLSPDGQVLVVGRPSTTKVFHLQPVGNKLK 461 Query: 445 VPISYNSSCVALSN------DKQFVAVGGQDSKVHVYKLSG--------------ASVSE 484 V N + S D + + + V + L S Sbjct: 462 VTKLDNDLLLRTSTKLVKFIDNSKIVICSCEDDVFIVDLESEEDEKPQEVELLEVTSTKS 521 Query: 485 VKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSW 544 + + I + N A + ++ + LA N++ + V Sbjct: 522 SIKVPYINRINHLEVDQNIAVISRGCGVVDILDLKARISKPLARLNNF------ITAVHI 575 Query: 545 SPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNI 604 + + + DN + +NMN S+ + S + W T D+ Sbjct: 576 NTSRKSVVVITADNKIYEFNMNLNSEAE----NEDSESVLTQ--WSKNNT------DNLP 623 Query: 605 KFWN 608 K W Sbjct: 624 KEWK 627 Score = 65.3 bits (157), Expect = 7e-11, Method: Composition-based stats. Identities = 45/277 (16%), Positives = 91/277 (32%), Gaps = 18/277 (6%) Query: 56 TEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSES 115 + S P ASGD G+++ WD T L + V ++ D+++ Sbjct: 235 KKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFAT--LNQSFKAHDADVLCLTTDTDN 292 Query: 116 KRIAAVGEGRERFGHVFLFDTGTSNGNLTG------QARAMNS-VDFKPSRPFRIISGSD 168 + + G R+ F + N + + ++ ++SG Sbjct: 293 NYVFSAGVDRKIFQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGV 352 Query: 169 DNTVAIFEGPPFKFKSTFGEHTKFVHS--VRYNPDGSLFASTGGDGTIVLYNGVDGTKTG 226 + T+ I F + T +S V N + L S T+ ++ + T Sbjct: 353 EKTLVINSLTSFSNGNYRKMPTVEPYSKNVLVNKEQRLVVSWSE-STVKIWTMGTDSSTE 411 Query: 227 V-FEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNV----ATLKVEKTIPVGT 281 ++ + ++ + SPDG + T K++++ LKV K Sbjct: 412 QNYKLVCKLTLKDDQNISTCSLSPDGQVLVVG-RPSTTKVFHLQPVGNKLKVTKLDNDLL 470 Query: 282 RIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQ 318 +L +V S + V+ E ++ Sbjct: 471 LRTSTKLVKFIDNSKIVICSCEDDVFIVDLESEEDEK 507 Score = 58.7 bits (140), Expect = 7e-09, Method: Composition-based stats. Identities = 32/210 (15%), Positives = 72/210 (34%), Gaps = 20/210 (9%) Query: 420 SADGDIAVAACYKHIAIYS--HGKLTEVPISYNSS----CVALSN---DKQFVAVGGQDS 470 +D +A+ +I I++ + E+ I + SN + + G + Sbjct: 62 PSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCWSNVNGESLRLFSIGGST 121 Query: 471 KVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFE-LAHT 529 V + L+ + I S++ +++ L + V+ ++ L H Sbjct: 122 VVTEWDLATGLPLRNY-DCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVLEHD 180 Query: 530 NSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM---NKPSDHPIIIKGAHAMSSVNS 586 A+V ++W D + G D + +W+ ++ + ++ Sbjct: 181 TILMRQEARVLTLAWKKD-DFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKEST 239 Query: 587 VIW-----LNETTIVSAGQDSNIKFWNVPF 611 ++W I S +IKFW+ F Sbjct: 240 LVWSVIYLPRTDQIASGDSTGSIKFWDFQF 269 Score = 53.7 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 26/178 (14%), Positives = 69/178 (38%), Gaps = 12/178 (6%) Query: 437 YSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGA-SVSEVKTIVHPAEIT 495 ++ +T + S+ S+ L+ +A+G + + ++ V I Sbjct: 41 FTPATITSLAFSHKSNINKLTPSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIE 100 Query: 496 SVAFSN---NGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLA 552 + +SN L + S V + +A L ++ ++ + +S + +L+ Sbjct: 101 GLCWSNVNGESLRLFSIGGSTVVTEWDLATGLPL---RNYDCNSGVIWSISINDSQDKLS 157 Query: 553 TGSLDNSVIVWNMNKP---SDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFW 607 G + +V++ +++ +H I+ + V ++ W + ++ D I+ W Sbjct: 158 VGCDNGTVVLIDISGGPGVLEHDTILMRQE--ARVLTLAWKKDDFVIGGCSDGRIRIW 213 Score = 41.8 bits (96), Expect = 8e-04, Method: Composition-based stats. Identities = 54/417 (12%), Positives = 131/417 (31%), Gaps = 42/417 (10%) Query: 22 VVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEI-YTEHSHQTTVAKTSPSGYYCASGDVH 80 + P D+I + T + H T Y S V Sbjct: 242 WSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAGVD 301 Query: 81 GNVRIWDTTQTTHILKTTIPV--------FSGPVKDISWDSESKRIAAVGEGRERFGHVF 132 +I+ +Q T+ + ++ I V G E+ + Sbjct: 302 R--KIFQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVIN 359 Query: 133 LFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF----EGPPFK-----FK 183 + ++ S + ++ R++ ++TV I+ + + K Sbjct: 360 SLTSFSNGNYRKMPTVEPYSKNVLVNKEQRLVVSWSESTVKIWTMGTDSSTEQNYKLVCK 419 Query: 184 STFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVD-GTKTGVFEDDSLKNVAHSGSV 242 T + + + + +PDG + G T +++ G K V + D+ + S Sbjct: 420 LTLKD-DQNISTCSLSPDGQVLV-VGRPSTTKVFHLQPVGNKLKVTKLDNDLLL--RTST 475 Query: 243 FGLTWSPDGTKIASASADKTIKIWNVATLKVEK-----------TIPVGTRIEDQQLGII 291 + + + + + D + I ++ + + EK T ++ + Sbjct: 476 KLVKFIDNSKIVICSCEDD-VFIVDLESEEDEKPQEVELLEVTSTKSSIKVPYINRINHL 534 Query: 292 WTKQALVSISAN-GFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINS 350 Q + IS G ++ ++ + I + N ITA+ + K++ A+ I Sbjct: 535 EVDQNIAVISRGCGVVDILDLK-ARISKPLARLNNFITAVHINTSRKSVVVITADNKIYE 593 Query: 351 WDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVA 407 ++++ + + + + + D W + S +++S + Sbjct: 594 FNMNLNSEA---ENEDSESVLTQWSKNNTDNLPKEWKTLKENCVGIFSDIENSSRLW 647 >6EM1-m nrPDB Length = 807 Score = 101 bits (250), Expect = 1e-21, Method: Composition-based stats. Identities = 60/366 (16%), Positives = 124/366 (33%), Gaps = 44/366 (12%) Query: 17 ARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCAS 76 R L P + + + P+ + IY H + PSG + A+ Sbjct: 398 PRVRKNKLNIDPNSLIPELPSPKDLRPFPIRC---STIYAGHKGKVRTLSIDPSGLWLAT 454 Query: 77 GDVHGNVRIWDTTQTTHILKTTIPVFSG----PVKDISWDSE-SKRIAAV---------- 121 G G VR+W+ + +TT+ ++ I W+ + + I AV Sbjct: 455 GSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLIV 514 Query: 122 ----GEGRERFGHVFLFD--TGTSNGNLTGQARAMNSV-DFKPSRPFRIISGSDDNTVAI 174 G E G + D + G + +N D + VA Sbjct: 515 PPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQ 574 Query: 175 FEGPPFKFKS-----TFGEHTKFVHSVRYNPDGSLFASTGGDG---TIVLYNGVDGTKTG 226 + P K T K V + ++ G F + D +++++ Sbjct: 575 WNKPSQKQLEKDICITISC-KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQS 633 Query: 227 VFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQ 286 F+ G + + P ++ S + ++I++++ + K + G R Sbjct: 634 PFKKS-------KGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGAR-WLS 684 Query: 287 QLGIIWTKQALVSISANGFINFVNPELGSI-DQVRYGHNKAITALSSSADGKTLFSADAE 345 ++ I L++ S + + + + +L S + H KA+ +++ SA + Sbjct: 685 KIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADD 744 Query: 346 GHINSW 351 G I+ + Sbjct: 745 GTIHVF 750 Score = 86.1 bits (211), Expect = 4e-17, Method: Composition-based stats. Identities = 53/382 (13%), Positives = 107/382 (28%), Gaps = 93/382 (24%) Query: 315 SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVF--------PDVH 366 + GH + LS G L + +G + W+I TG PD H Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 487 Query: 367 ATMITGIKTTSKG---------------DLFTVSWDDHLKVVPAGGSGVDSSKAVANKLS 411 I + G +F +++ K G G D+ V Sbjct: 488 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 547 Query: 412 SQPLGLAVSADGD---------------------------IAVAACYKHIAIYSHGKLTE 444 DG+ +C K + S + + Sbjct: 548 EVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGD 607 Query: 445 VPISYNSSC----------------------------VALSNDKQFVAVGGQDSKVHVYK 476 ++ K + V Q V +Y Sbjct: 608 YFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYD 666 Query: 477 LSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHT 536 L + K + ++ + G L+A+ ++V+ + + + + +H Sbjct: 667 L-SQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDL--DLASTPYKTLRYHE 723 Query: 537 AKVACVSWSPDNVRLATGSLDNSVIVWN-------MNKPSDHPIIIKGAHAM----SSVN 585 V V++ ++ + D ++ V++ M P P+ H + ++ Sbjct: 724 KAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLD 783 Query: 586 SVIWLNETTIVSAGQDSNIKFW 607 ++ E + SAG D+ + W Sbjct: 784 AIWHPREAWLFSAGADNTARLW 805 Score = 45.6 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 20/86 (23%), Positives = 34/86 (39%), Gaps = 5/86 (5%) Query: 524 FELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM--NKPSDHPIIIKGAHAM 581 F + + + H KV +S P + LATGS D +V VW + + +I Sbjct: 425 FPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENP 484 Query: 582 S-SVNSVIWLNE--TTIVSAGQDSNI 604 + + W + I++ NI Sbjct: 485 DYHIECIEWNPDANNGILAVAVGENI 510 >5N4A-A nrPDB Length = 771 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 72/566 (12%), Positives = 166/566 (29%), Gaps = 87/566 (15%) Query: 93 HILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTG-----QA 147 + +++ V S + W+ ++ + + + L + L Sbjct: 4 KVKQSSANVHSELTAAVGWNVWNE-LFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHW 62 Query: 148 RAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFAS 207 ++S + D +V I + + + H S+R++ DG+ A+ Sbjct: 63 YPVSSKKTQAGGTDVFAVACTDGSVKILS-RTGRVEKSIEGHKGACISLRWSYDGTALAT 121 Query: 208 TGGDGTIVLYN-------------------------------GVDGTKTGVFEDDSLKNV 236 G DG++ +++ ++ +N Sbjct: 122 AGEDGSVKIWSRNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIKSLSSNAKQNA 181 Query: 237 --AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK 294 AH G V + WSP I + D K+W+ + + + + W Sbjct: 182 WKAHDGVVLKVDWSPINHLIITGGEDCKYKVWD----SFGRLLFQSGLFDYPVTSVAWAP 237 Query: 295 QA-LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 L ++ + + + ++ +I LS +AD L Sbjct: 238 SGELFAVGGFNTLQLCDRMGWAYSKIHLNDTGSIMTLSWTADSTQLA------------- 284 Query: 354 STGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQ 413 + + V+ D +++V ++ + + Sbjct: 285 ------GGGGSGGVVFGQVVDLALEDGKMQVTVVDDMRIVVNDILNENADELPEFRDR-- 336 Query: 414 PLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQF-VAVGGQDSKV 472 + VS + A +Y+ L I V L + + + + Sbjct: 337 --VIKVSLGYGYLIVATATQCHVYNTTNLGTPHIFDLKDTVTLLLQAERHFLLLDNSAGI 394 Query: 473 HVYKLSGAS-VSEVKTIVHPAEITS--VAFSNNG-AFLVATDQSRKVIPYSVANNFELAH 528 +Y G + + + + + SN+ A L V + A + Sbjct: 395 QIYTYEGRQICNPRFQGLRTELLNAQMITLSNDTIAVLDQQASGTTVRFFDTAQGRPVGE 454 Query: 529 TNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVI 588 HT +V ++ S D +IV +++ D ++ ++ + ++ Sbjct: 455 PWQ---HTLEVKEIALSQAGTI-----NDRQLIV--IDRNRDLYLLPVMKRHVAKLAAMC 504 Query: 589 ----WLNETTIVSAGQDSNIKFWNVP 610 W + T ++SA D + W P Sbjct: 505 DSARWHDSTAMLSAMVDQRLCVWYYP 530 Score = 98.4 bits (243), Expect = 7e-21, Method: Composition-based stats. Identities = 42/226 (18%), Positives = 79/226 (34%), Gaps = 16/226 (7%) Query: 30 GDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTT 89 D + + + H + S G A+ G+V+IW Sbjct: 75 TDVFAVACTDGSVKILSRTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKIWSRN 134 Query: 90 QTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARA 149 +L++T+ PV I W + ++ + + Sbjct: 135 ---GMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSN---VVIKSLSSNAKQNAWKAHDGV 188 Query: 150 MNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTG 209 + VD+ P II+G +D +++ + G V SV + P G LFA G Sbjct: 189 VLKVDWSPINHL-IITGGEDCKYKVWD-SFGRLLFQSGLFDYPVTSVAWAPSGELFAVGG 246 Query: 210 GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIA 255 T+ L + + + + +D +GS+ L+W+ D T++A Sbjct: 247 F-NTLQLCDRMGWAYSKIHLND-------TGSIMTLSWTADSTQLA 284 Score = 56.4 bits (134), Expect = 4e-08, Method: Composition-based stats. Identities = 64/501 (12%), Positives = 140/501 (27%), Gaps = 70/501 (13%) Query: 5 SQTALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTV 64 S+ + S A + D++ YC G++V + S + H Sbjct: 132 SRNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIKSLSSNAKQNAWKAHDGVVLK 191 Query: 65 AKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEG 124 SP + +G ++WD + L +F PV ++W + A G Sbjct: 192 VDWSPINHLIITGGEDCKYKVWD---SFGRLLFQSGLFDYPVTSVAWAPSGELFAVGGFN 248 Query: 125 R--------ERFGHVFLFDTGT-------------SNGNLTGQARAMNSVDFKPSRPFRI 163 + + L DTG+ + G +G VD Sbjct: 249 TLQLCDRMGWAYSKIHLNDTGSIMTLSWTADSTQLAGGGGSGGVVFGQVVDLALEDGKMQ 308 Query: 164 ISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGT 223 ++ DD + + + E V V + A+ +YN + Sbjct: 309 VTVVDDMRIVVNDILNENADE-LPEFRDRVIKVSLGYGYLIVATA---TQCHVYNTTNLG 364 Query: 224 KTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRI 283 +F+ + L + SA I+I+ ++ G R Sbjct: 365 TPHIFDLKDTVTLLLQAERHFL--------LLDNSA--GIQIYTYEGRQICNPRFQGLRT 414 Query: 284 EDQQLGIIWTKQALVSI----SANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTL 339 E +I +++ ++ + F + G + H + ++ S G Sbjct: 415 ELLNAQMITLSNDTIAVLDQQASGTTVRFFDTAQGRPVGEPWQHTLEVKEIALSQAGTI- 473 Query: 340 FSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSG 399 + + D + + H + + Sbjct: 474 ----NDRQLIVIDRNRDLYLLPVMKRHVAKLAAMC--------------------DSARW 509 Query: 400 VDSSKAVANKLSSQPLGLAVSAD---GDIAVAACYKHIAIYSHGKLTEVPISYNSSCVAL 456 DS+ ++ + + ++ +A + GK ++ + + C+ Sbjct: 510 HDSTAMLSAMVDQRLCVWYYPSEVYVDKDLLAKTRYTKSDSDFGKSAQIQLFAGNRCLVR 569 Query: 457 SNDKQFVAVGGQDSKVHVYKL 477 +D V+ +Y + Sbjct: 570 RSDGVLVSAATSPYPAVLYDM 590 >6C0F-s nrPDB Length = 807 Score = 100 bits (249), Expect = 2e-21, Method: Composition-based stats. Identities = 60/366 (16%), Positives = 124/366 (33%), Gaps = 44/366 (12%) Query: 17 ARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCAS 76 R L P + + + P+ + IY H + PSG + A+ Sbjct: 398 PRVRKNKLNIDPNSLIPELPSPKDLRPFPIRC---STIYAGHKGKVRTLSIDPSGLWLAT 454 Query: 77 GDVHGNVRIWDTTQTTHILKTTIPVFSG----PVKDISWDSE-SKRIAAV---------- 121 G G VR+W+ + +TT+ ++ I W+ + + I AV Sbjct: 455 GSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLIV 514 Query: 122 ----GEGRERFGHVFLFD--TGTSNGNLTGQARAMNSV-DFKPSRPFRIISGSDDNTVAI 174 G E G + D + G + +N D + VA Sbjct: 515 PPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQ 574 Query: 175 FEGPPFKFKS-----TFGEHTKFVHSVRYNPDGSLFASTGGDG---TIVLYNGVDGTKTG 226 + P K T K V + ++ G F + D +++++ Sbjct: 575 WNKPSQKQLEKDICITISC-KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQS 633 Query: 227 VFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQ 286 F+ G + + P ++ S + ++I++++ + K + G R Sbjct: 634 PFKKS-------KGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGAR-WLS 684 Query: 287 QLGIIWTKQALVSISANGFINFVNPELGSI-DQVRYGHNKAITALSSSADGKTLFSADAE 345 ++ I L++ S + + + + +L S + H KA+ +++ SA + Sbjct: 685 KIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADD 744 Query: 346 GHINSW 351 G I+ + Sbjct: 745 GTIHVF 750 Score = 85.7 bits (210), Expect = 5e-17, Method: Composition-based stats. Identities = 53/382 (13%), Positives = 107/382 (28%), Gaps = 93/382 (24%) Query: 315 SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVF--------PDVH 366 + GH + LS G L + +G + W+I TG PD H Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 487 Query: 367 ATMITGIKTTSKG---------------DLFTVSWDDHLKVVPAGGSGVDSSKAVANKLS 411 I + G +F +++ K G G D+ V Sbjct: 488 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 547 Query: 412 SQPLGLAVSADGD---------------------------IAVAACYKHIAIYSHGKLTE 444 DG+ +C K + S + + Sbjct: 548 EVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGD 607 Query: 445 VPISYNSSC----------------------------VALSNDKQFVAVGGQDSKVHVYK 476 ++ K + V Q V +Y Sbjct: 608 YFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYD 666 Query: 477 LSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHT 536 L + K + ++ + G L+A+ ++V+ + + + + +H Sbjct: 667 L-SQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDL--DLASTPYKTLRYHE 723 Query: 537 AKVACVSWSPDNVRLATGSLDNSVIVWN-------MNKPSDHPIIIKGAHAM----SSVN 585 V V++ ++ + D ++ V++ M P P+ H + ++ Sbjct: 724 KAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLD 783 Query: 586 SVIWLNETTIVSAGQDSNIKFW 607 ++ E + SAG D+ + W Sbjct: 784 AIWHPREAWLFSAGADNTARLW 805 Score = 45.6 bits (106), Expect = 7e-05, Method: Composition-based stats. Identities = 20/86 (23%), Positives = 34/86 (39%), Gaps = 5/86 (5%) Query: 524 FELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM--NKPSDHPIIIKGAHAM 581 F + + + H KV +S P + LATGS D +V VW + + +I Sbjct: 425 FPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENP 484 Query: 582 S-SVNSVIWLNE--TTIVSAGQDSNI 604 + + W + I++ NI Sbjct: 485 DYHIECIEWNPDANNGILAVAVGENI 510 >6CB1-s nrPDB Length = 569 Score = 100 bits (248), Expect = 2e-21, Method: Composition-based stats. Identities = 60/366 (16%), Positives = 124/366 (33%), Gaps = 44/366 (12%) Query: 17 ARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCAS 76 R L P + + + P+ + IY H + PSG + A+ Sbjct: 160 PRVRKNKLNIDPNSLIPELPSPKDLRPFPIRC---STIYAGHKGKVRTLSIDPSGLWLAT 216 Query: 77 GDVHGNVRIWDTTQTTHILKTTIPVFSG----PVKDISWDSE-SKRIAAV---------- 121 G G VR+W+ + +TT+ ++ I W+ + + I AV Sbjct: 217 GSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLIV 276 Query: 122 ----GEGRERFGHVFLFD--TGTSNGNLTGQARAMNSV-DFKPSRPFRIISGSDDNTVAI 174 G E G + D + G + +N D + VA Sbjct: 277 PPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQ 336 Query: 175 FEGPPFKFKS-----TFGEHTKFVHSVRYNPDGSLFASTGGDG---TIVLYNGVDGTKTG 226 + P K T K V + ++ G F + D +++++ Sbjct: 337 WNKPSQKQLEKDICITISC-KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQS 395 Query: 227 VFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQ 286 F+ G + + P ++ S + ++I++++ + K + G R Sbjct: 396 PFKKS-------KGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGAR-WLS 446 Query: 287 QLGIIWTKQALVSISANGFINFVNPELGSI-DQVRYGHNKAITALSSSADGKTLFSADAE 345 ++ I L++ S + + + + +L S + H KA+ +++ SA + Sbjct: 447 KIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADD 506 Query: 346 GHINSW 351 G I+ + Sbjct: 507 GTIHVF 512 Score = 85.7 bits (210), Expect = 6e-17, Method: Composition-based stats. Identities = 53/382 (13%), Positives = 107/382 (28%), Gaps = 93/382 (24%) Query: 315 SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVF--------PDVH 366 + GH + LS G L + +G + W+I TG PD H Sbjct: 190 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 249 Query: 367 ATMITGIKTTSKG---------------DLFTVSWDDHLKVVPAGGSGVDSSKAVANKLS 411 I + G +F +++ K G G D+ V Sbjct: 250 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 309 Query: 412 SQPLGLAVSADGD---------------------------IAVAACYKHIAIYSHGKLTE 444 DG+ +C K + S + + Sbjct: 310 EVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGD 369 Query: 445 VPISYNSSC----------------------------VALSNDKQFVAVGGQDSKVHVYK 476 ++ K + V Q V +Y Sbjct: 370 YFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYD 428 Query: 477 LSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHT 536 L + K + ++ + G L+A+ ++V+ + + + + +H Sbjct: 429 L-SQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDL--DLASTPYKTLRYHE 485 Query: 537 AKVACVSWSPDNVRLATGSLDNSVIVWN-------MNKPSDHPIIIKGAHAM----SSVN 585 V V++ ++ + D ++ V++ M P P+ H + ++ Sbjct: 486 KAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLD 545 Query: 586 SVIWLNETTIVSAGQDSNIKFW 607 ++ E + SAG D+ + W Sbjct: 546 AIWHPREAWLFSAGADNTARLW 567 Score = 45.6 bits (106), Expect = 7e-05, Method: Composition-based stats. Identities = 20/86 (23%), Positives = 34/86 (39%), Gaps = 5/86 (5%) Query: 524 FELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM--NKPSDHPIIIKGAHAM 581 F + + + H KV +S P + LATGS D +V VW + + +I Sbjct: 187 FPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENP 246 Query: 582 S-SVNSVIWLNE--TTIVSAGQDSNI 604 + + W + I++ NI Sbjct: 247 DYHIECIEWNPDANNGILAVAVGENI 272 >3W15-A nrPDB Length = 368 Score = 98.0 bits (242), Expect = 1e-20, Method: Composition-based stats. Identities = 43/298 (14%), Positives = 90/298 (30%), Gaps = 54/298 (18%) Query: 24 LGNTPA-GDKIQYCNGTSVYTVPVGSLTD--TEIYTEHSHQTTVAKTS-PSGYYCASGDV 79 L + +++ G + + + I+ EH + + + S Sbjct: 68 LAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSW 127 Query: 80 HGNVRIWDTTQTTHILKTT-------------------------IPVFSGPVKDISWDS- 113 G+++IW + ++ T I V + Sbjct: 128 DGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPH 187 Query: 114 ESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQAR-AMNSVDFKPSRPFRIISGSDDNTV 172 + + + +G + N + + DF RP+ + +G DN + Sbjct: 188 DQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAI 247 Query: 173 AIFEGP----------PFKFKSTFGE-HTKFVHSVRYNPDGS-LFASTGGDGTIVLY-NG 219 I++ + H + V ++P S + S D T ++ + Sbjct: 248 RIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDL 307 Query: 220 VDGTKTGVFEDDSLK--------NVAHSGSVFGLTWSPDGT--KIASASADKTIKIWN 267 + ++ +S HS VFG WS G +AS + D + +WN Sbjct: 308 SNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 Score = 89.5 bits (220), Expect = 4e-18, Method: Composition-based stats. Identities = 55/346 (15%), Positives = 114/346 (32%), Gaps = 54/346 (15%) Query: 93 HILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNS 152 +L+ + FSG S +++ A G G+ LF + +G+ +NS Sbjct: 2 SMLRYHMQGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLF---ILEIDRSGRIVEVNS 58 Query: 153 ---------VDFKPSRPFRIISGSDDNTVAIFEGPPFKF-KSTFGEHTKFVHSVRYN-PD 201 + + S +++ D T+ +F+ +F + F EH + V S +N + Sbjct: 59 FLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVN 118 Query: 202 GSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGS-------------------- 241 F S+ DG+I +++ + L+ Sbjct: 119 RQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNC 178 Query: 242 VFGLTWSP-DGTKIASASADKTIKIWN--VATLKVEKTIPVGTRIEDQQLGIIWTKQALV 298 V+ +SP D + S S + +++ + + K + V + +E + +V Sbjct: 179 VYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVV 238 Query: 299 -SISANGFINFVNPEL-----------GSIDQVRYGHNKAITALSSSA-DGKTLFSADAE 345 + + I + + I+++ H AI ++ S L SA + Sbjct: 239 ATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYD 298 Query: 346 GHINSW-DISTGISNRVFPDVHATMITGIKTTSKGD---LFTVSWD 387 W D+S + + G +F W Sbjct: 299 MTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWS 344 Score = 85.7 bits (210), Expect = 5e-17, Method: Composition-based stats. Identities = 38/336 (11%), Positives = 96/336 (28%), Gaps = 49/336 (14%) Query: 260 DKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGS-IDQ 318 D++ +I V + + + E + ++ +G + + Sbjct: 48 DRSGRIVEVNSFLTQDCLFDLAWNESHE-------NQVLVAQGDGTLRLFDTTFKEFPIA 100 Query: 319 VRYGHNKAITALSSS-ADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTS 377 + H + + + + + + + S+ +G I W S Sbjct: 101 IFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTL-----------TPRP 149 Query: 378 KGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIY 437 V + + + +G+ ++ + P + A I + Sbjct: 150 LEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLP 209 Query: 438 SHGKLTEVPISYNSSCVA--LSNDKQF-VAVGGQDSKVHVYKLS----------GASVSE 484 S + + + + + VA GG D+ + ++ + +S Sbjct: 210 SGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCIN 269 Query: 485 VKTIVHPAEITSVAFSN-NGAFLVATDQSRKVIPY------SVANNFELAHTNSWTF--- 534 H I V +S + L++ + ++ T++ Sbjct: 270 EIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIF 329 Query: 535 ----HTAKVACVSWSPDNV--RLATGSLDNSVIVWN 564 H+ V WS +A+ + D ++ VWN Sbjct: 330 NFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 Score = 83.0 bits (203), Expect = 3e-16, Method: Composition-based stats. Identities = 52/360 (14%), Positives = 115/360 (31%), Gaps = 78/360 (21%) Query: 63 TVAKTSP---SGYYCASGD-----VHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSE 114 + SP + A+G +G + I + ++ I++ + + D++W+ Sbjct: 14 YGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNES 73 Query: 115 SKRIAAVGEGRERFGHVFLFDT---GTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNT 171 + V +G G + LFDT R + S ++ +S S D + Sbjct: 74 HENQVLVAQG---DGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGS 130 Query: 172 VAIFE---------GPPFKFKST------------------FGEHTKFVHSVRYNP-DGS 203 + I+ P + T ++ V+ +++P D + Sbjct: 131 IKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQN 190 Query: 204 LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSG-SVFGLTWSPDGTKI-ASASADK 261 L S G+ L++ + + + HSG ++ + A+ D Sbjct: 191 LVLSCSGNSYASLFDIRLPSG-----KNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDN 245 Query: 262 TIKIWNVA----------TLKVEKTIPVGTRIEDQQLGIIW-TKQALVSISANGFINFV- 309 I+IW++ IP + +++ L+S S + Sbjct: 246 AIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWR 305 Query: 310 -NPELGSIDQVRYG--------------HNKAITALSSSADGK--TLFSADAEGHINSWD 352 G+ + + H++ + S GK + S +G++ W+ Sbjct: 306 DLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 Score = 68.0 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 33/189 (17%), Positives = 63/189 (33%), Gaps = 32/189 (16%) Query: 62 TTVAKTSP-SGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSES-KRIA 119 A+ SP S + ++D + + V SG ++ ++ D + Sbjct: 179 VYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSG-LEALTCDFNKYRPYV 237 Query: 120 AVGEGRERFGHVFL-----------FDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSD 168 G + ++ ++ N A+ V + P ++S S Sbjct: 238 VATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASY 297 Query: 169 DNTVAIF-EGPPFKFKST---------------FGEHTKFVHSVRYNPDGS--LFASTGG 210 D T I+ + K T F +H++FV ++ G AST Sbjct: 298 DMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAW 357 Query: 211 DGTIVLYNG 219 DG + ++NG Sbjct: 358 DGNLFVWNG 366 Score = 60.3 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 53/365 (14%), Positives = 111/365 (30%), Gaps = 55/365 (15%) Query: 281 TRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAIT-ALSSS-ADGKT 338 + D +L + + + FI ++ G I +V + L+ + + Sbjct: 19 SPFFDNRLAVAAGSNFGLVGNGKLFILEID-RSGRIVEVNSFLTQDCLFDLAWNESHENQ 77 Query: 339 LFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTT--SKGDLFTVSWDDHLKVVPAG 396 + A +G + +D + H + ++ + + SWD +K+ Sbjct: 78 VLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPL 137 Query: 397 GSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCV-- 454 K L+ +PL + + K + IS N +CV Sbjct: 138 R------KQSLMTLTPRPL----------EITKMVDPLNAIILKKKSFTGISKNRNCVYQ 181 Query: 455 -ALSN-DKQFVAVGGQDSKVHVYKLS---GASVSEVKTIVHPAEITSVAFSNNGAFLVA- 508 S D+ V +S ++ + G + + +T F+ ++VA Sbjct: 182 AQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTC-DFNKYRPYVVAT 240 Query: 509 TDQSRKVIPYSV----ANNFELAHT----NSWTFHTAKVACVSWSPDN-VRLATGSLDNS 559 + + + N +L ++ H + V+WSP + L + S D + Sbjct: 241 GGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMT 300 Query: 560 VIVWNMNKPSDHPIIIKGAHAMS----------------SVNSVIWLNETTIVSAGQDSN 603 +W K + + +W + S D N Sbjct: 301 CRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGN 360 Query: 604 IKFWN 608 + WN Sbjct: 361 LFVWN 365 Score = 48.3 bits (113), Expect = 9e-06, Method: Composition-based stats. Identities = 27/222 (12%), Positives = 69/222 (31%), Gaps = 30/222 (13%) Query: 416 GLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVY 475 + +G + + + I ++ + ++ VA G D + ++ Sbjct: 33 NFGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQG--DGTLRLF 90 Query: 476 KLSGASVSEVKTIVHPAEITSVAFS-NNGAFLVATDQSRKVIPYSVANNFELAHT----- 529 + H E+ S ++ N +++ + +S L Sbjct: 91 DTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPL 150 Query: 530 ----------------NSWTFHTAKVACV---SWSP-DNVRLATGSLDNSVIVWNMNKPS 569 S+T + CV +SP D + + S ++ ++++ PS Sbjct: 151 EITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPS 210 Query: 570 DHPIIIKGAHAMSSVNSVIWLNET--TIVSAGQDSNIKFWNV 609 H+ + + + + G D+ I+ W++ Sbjct: 211 GKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDI 252 >5WLC-LJ nrPDB Length = 513 Score = 97.2 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 42/288 (14%), Positives = 97/288 (33%), Gaps = 28/288 (9%) Query: 19 GTAVVLGNTP-AGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASG 77 + + P + T V + + ++ A G +G Sbjct: 40 NSVTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIKTFSRFKDVVYSASFRSDGKLLCAG 99 Query: 78 DVHGNVRIWDTTQ-TTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLF-D 135 D G V ++D+ T +L V + ++ +I A +R ++ + Sbjct: 100 DATGLVSVYDSYNPRTILLSINASTHPTHVT--KFHTQDNKILATASD-DRVTRLWDISN 156 Query: 136 TGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFG-EHTKFVH 194 LTG + ++ F P+ P + +GS D + +++ + H + V Sbjct: 157 AYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVE 216 Query: 195 SV-RYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW-----S 248 +V +P S GG+ +++ K + + +V L + S Sbjct: 217 NVIAVSPTQ--IVSCGGNNF-KVWDLTSNKKLY-------ERGNFNKAVTCLDYVENFDS 266 Query: 249 PDGTKIASASADKTIKIWN-VATLKVEKTIPVGTRIEDQQLGIIWTKQ 295 P + + ++S D +K+++ + + + G + L + Sbjct: 267 PMQSALIASSLDGHVKVFDPLDNFQ----VKFGWKFSGPVLSCAVSPS 310 Score = 96.1 bits (237), Expect = 4e-20, Method: Composition-based stats. Identities = 49/269 (18%), Positives = 92/269 (34%), Gaps = 20/269 (7%) Query: 134 FDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFV 193 + TS + + + F P P S V IF + TF V Sbjct: 27 WRQYTSAQLVKEHNS-VTHISFNPQHPHDFAVTS-STRVQIFSSRTRQVIKTFSRFKDVV 84 Query: 194 HSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTK 253 +S + DG L + G + +Y+ + +T + ++ + H D Sbjct: 85 YSASFRSDGKLLCAGDATGLVSVYDSYNP-RTILLSINASTHPTHVTKFHT----QDNKI 139 Query: 254 IASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALV-SISANGFINFVNPE 312 +A+AS D+ ++W+++ + G + L I LV + S +G I + Sbjct: 140 LATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTR 199 Query: 313 -LGSIDQVRYGHNKAI-TALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMI 370 GS H++ + ++ S + S + WD+++ + Sbjct: 200 SSGSTPIYSLNHDQPVENVIAVSP--TQIVSCGG-NNFKVWDLTSNKKL-YERGNFNKAV 255 Query: 371 TGIKTTSKGD------LFTVSWDDHLKVV 393 T + D L S D H+KV Sbjct: 256 TCLDYVENFDSPMQSALIASSLDGHVKVF 284 Score = 80.7 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 41/213 (19%), Positives = 78/213 (36%), Gaps = 14/213 (6%) Query: 400 VDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSND 459 +S + P AV++ + + + I + + +V + +D Sbjct: 38 EHNSVTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIKTFSRFKDV-----VYSASFRSD 92 Query: 460 KQFVAVGGQDSKVHVYKLSGAS--VSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIP 517 + + G V VY + + HP +T + + L R Sbjct: 93 GKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFH-TQDNKILATASDDRVTRL 151 Query: 518 YSVANNFELAHTNSWTFHTAKVACVSWSPD-NVRLATGSLDNSVIVWNMNKPSDHPIIIK 576 + ++N +E T T V +S+ P +ATGS D + +++ PI Sbjct: 152 WDISNAYEPQL--ELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPI--Y 207 Query: 577 GAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 + V +VI ++ T IVS G +N K W++ Sbjct: 208 SLNHDQPVENVIAVSPTQIVSCGG-NNFKVWDL 239 Score = 73.0 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 38/308 (12%), Positives = 89/308 (28%), Gaps = 54/308 (17%) Query: 264 KIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGH 323 + W T V + +++++ + + + + Sbjct: 25 RYWRQYTSAQL----VKEHNSVTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIKTFSRF 80 Query: 324 NKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKT-TSKGDLF 382 + + S +DGK L + DA G ++ +D + + + K T + Sbjct: 81 KDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKIL 140 Query: 383 TVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKL 442 + DD + + + + + + A Sbjct: 141 ATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPH------------------ 182 Query: 443 TEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEI-TSVAFSN 501 VA G D + +Y + + + ++ H + +A S Sbjct: 183 -------------------LVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVENVIAVSP 223 Query: 502 NGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSW-----SPDNVRLATGSL 556 +V+ + + + +N +L ++ V C+ + SP L SL Sbjct: 224 T--QIVSCGGN-NFKVWDLTSNKKLYERGNFN---KAVTCLDYVENFDSPMQSALIASSL 277 Query: 557 DNSVIVWN 564 D V V++ Sbjct: 278 DGHVKVFD 285 Score = 62.6 bits (150), Expect = 5e-10, Method: Composition-based stats. Identities = 29/177 (16%), Positives = 67/177 (37%), Gaps = 4/177 (2%) Query: 432 KHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHP 491 ++ Y+ +L + + + ++ + ++V ++ V + + Sbjct: 25 RYWRQYTSAQLVKE--HNSVTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIKTFSRF-K 81 Query: 492 AEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRL 551 + S +F ++G L A D + V Y N + + + + H V + DN L Sbjct: 82 DVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFH-TQDNKIL 140 Query: 552 ATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 AT S D +W+++ + + + GA S I + + D I+ ++ Sbjct: 141 ATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYD 197 >5OQL-X nrPDB Length = 630 Score = 95.7 bits (236), Expect = 5e-20, Method: Composition-based stats. Identities = 50/441 (11%), Positives = 105/441 (23%), Gaps = 80/441 (18%) Query: 53 EIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWD 112 + +S T P Y + G + W Sbjct: 164 TQFRWNSGTVTSVAVCPP--YAYTTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKPPAPPK 221 Query: 113 SESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTV 172 +RI + ++ G +A V F +++G D + Sbjct: 222 KRPERICFAKADARKA----------NDKTYQGHLKAPLVVKASQDGKF-VVTGGADKRL 270 Query: 173 AIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDS 232 ++ K F +H V + + + S D T+ +++ + Sbjct: 271 VVYNAADLKPIKAFTQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAYVETL---- 326 Query: 233 LKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKV------------------- 273 H + + ++ + D+T + W V Sbjct: 327 ---FGHQDEILDIDALGQERCVSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKL 383 Query: 274 ---EKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQ-VRYGH------ 323 ++ +I V+ S NG + + + + H Sbjct: 384 PPGMDPASAAHEGSMDRVAMI-DDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPI 442 Query: 324 --------------------NKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFP 363 + ITAL + +FS +G I W +S Sbjct: 443 KLEDYSADEIPDPSIIPAPQPRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDK------ 496 Query: 364 DVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADG 423 + + G + + + G +S + S + Sbjct: 497 ----RKLEAVGILGVGSETCENSTNISNGATSNGESSSTSSSTTLAAQSSSSSSPPPSQP 552 Query: 424 DIAVAACYKHIAIYSHGKLTE 444 V IA++ G+ Sbjct: 553 KDLVRGIVNDIALFERGERGR 573 Score = 89.9 bits (221), Expect = 3e-18, Method: Composition-based stats. Identities = 32/179 (17%), Positives = 68/179 (37%), Gaps = 28/179 (15%) Query: 453 CVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQS 512 V S D +FV GG D ++ VY + + T H +T +AF L + + Sbjct: 251 VVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQ-HRDAVTGLAFRRGTNQLYSCSKD 309 Query: 513 RKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHP 572 R V +S+ ELA+ + H ++ + ++ G+ D + W + + S Sbjct: 310 RTVKVWSLD---ELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARYWKVPEES--Q 364 Query: 573 IIIKGAH----------------------AMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 ++ +G S++ V +++ V+ + ++ W++ Sbjct: 365 LVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDDMFVTGSDNGDLALWSI 423 Score = 85.7 bits (210), Expect = 5e-17, Method: Composition-based stats. Identities = 23/122 (18%), Positives = 52/122 (42%), Gaps = 5/122 (4%) Query: 489 VHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDN 548 H V S +G F+V ++++ Y+ A+ L ++T H V +++ Sbjct: 244 GHLKAPLVVKASQDGKFVVTGGADKRLVVYNAAD---LKPIKAFTQHRDAVTGLAFRRGT 300 Query: 549 VRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 +L + S D +V VW++++ + + + ++ E + +D ++W Sbjct: 301 NQLYSCSKDRTVKVWSLDELAYVETLFGHQDEI--LDIDALGQERCVSVGARDRTARYWK 358 Query: 609 VP 610 VP Sbjct: 359 VP 360 Score = 77.6 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 50/349 (14%), Positives = 99/349 (28%), Gaps = 67/349 (19%) Query: 184 STFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLY---NGVDGTKTGVF------------ 228 + F ++ V SV P +T DG + + + Sbjct: 164 TQFRWNSGTVTSVAVCP--PYAYTTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKPPAPPK 221 Query: 229 --------------EDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVE 274 + + H + + S DG + + ADK + ++N A LK Sbjct: 222 KRPERICFAKADARKANDKTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPI 281 Query: 275 KTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSA 334 K R L L S S + + + + + + +GH I + + Sbjct: 282 KAF-TQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALG 340 Query: 335 DGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVP 394 + + + W + S VF G + +K D P Sbjct: 341 QERCVSVGARDRTARYWKV-PEESQLVFRGGGE----GGSSNTKKHKLPPGMD------P 389 Query: 395 AGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGK------------- 441 A + S VA + + S +GD+A+ + + ++ + Sbjct: 390 ASAAHEGSMDRVAMIDDD--MFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDY 447 Query: 442 ---------LTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGAS 481 + P + + + G D + V++LS Sbjct: 448 SADEIPDPSIIPAPQPRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDK 496 Score = 71.1 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 39/264 (14%), Positives = 68/264 (25%), Gaps = 46/264 (17%) Query: 30 GDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDT 88 G + V L + +T+H T S V++W Sbjct: 258 GKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSL 317 Query: 89 TQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQAR 148 T+ + DI D+ + R+R + + G Sbjct: 318 --DELAYVETLFGHQDEILDI--DALGQERCVSVGARDRTARYWKVPEESQLVFRGGGE- 372 Query: 149 AMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFAST 208 G NT + PP ++ H + V D +F + Sbjct: 373 -----------------GGSSNTKK-HKLPPGMDPAS-AAHEGSMDRVAMI-DDDMFVTG 412 Query: 209 GGDGTIVLYNGVDGTKTGV--------------------FEDDSLKNVAHSGSVFGLTWS 248 +G + L++ V D S+ + L Sbjct: 413 SDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTL 472 Query: 249 PDGTKIASASADKTIKIWNVATLK 272 P I S S D I++W ++ K Sbjct: 473 PYSDLIFSGSWDGCIRVWRLSEDK 496 Score = 68.4 bits (165), Expect = 8e-12, Method: Composition-based stats. Identities = 39/336 (11%), Positives = 87/336 (25%), Gaps = 63/336 (18%) Query: 324 NKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFT 383 + +T+++ ++ +G++ W + D+ Sbjct: 170 SGTVTSVAVCP--PYAYTTTKDGYLTKWKLQ---------DLPKNQWPQTTKKKPKKPPA 218 Query: 384 VSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAV-AACYKHIAIYSHGKL 442 ++ A ++ PL + S DG V K + +Y+ L Sbjct: 219 PPKKRPERICFAKADARKANDKTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADL 278 Query: 443 TEVPISYN----SSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVA 498 + + +A + +D V V+ L + E H EI + Sbjct: 279 KPIKAFTQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAYVETL-FGHQDEILDID 337 Query: 499 FSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTF--------------------HTAK 538 + + R + V +L H Sbjct: 338 ALGQERCVSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGS 397 Query: 539 VACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT---- 594 + V+ D+ TGS + + +W++ + +I + + + + Sbjct: 398 MDRVAMI-DDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPS 456 Query: 595 ---------------------IVSAGQDSNIKFWNV 609 I S D I+ W + Sbjct: 457 IIPAPQPRGITALRTLPYSDLIFSGSWDGCIRVWRL 492 Score = 51.4 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 20/153 (13%), Positives = 45/153 (29%), Gaps = 37/153 (24%) Query: 491 PAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELA----------------------- 527 +TSVA + T + + + + + + Sbjct: 170 SGTVTSVAVCP--PYAYTTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKPPAPPKKRPERI 227 Query: 528 ----------HTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKG 577 + ++ H V S D + TG D ++V+N + Sbjct: 228 CFAKADARKANDKTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQH 287 Query: 578 AHAMSSVNSVIWLNETTIVSAGQDSNIKFWNVP 610 A++ + N+ + S +D +K W++ Sbjct: 288 RDAVTGLAFRRGTNQ--LYSCSKDRTVKVWSLD 318 >5YZG-2 nrPDB Length = 646 Score = 95.7 bits (236), Expect = 5e-20, Method: Composition-based stats. Identities = 42/224 (18%), Positives = 81/224 (36%), Gaps = 19/224 (8%) Query: 72 YYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGR-ERFGH 130 + + G+V+ W + G ++ I+ SE +VG+ + + Sbjct: 102 DFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGALFCSVGDDKAMKVFD 161 Query: 131 VFLFDTGT--SNGNLTGQARAMNSVDFKPSRPFRIISGSDDNT--VAIFEGP-PFKFKST 185 V FD G GQ + P ++ S+ +T + I++G + Sbjct: 162 VVNFDMINMLKLGYFPGQCEWIYC----PGDAISSVAASEKSTGKIFIYDGRGDNQPLHI 217 Query: 186 FGE-HTKFVHSVRYNPDGSLFASTGGDGTIVLYNG--------VDGTKTGVFEDDSLKNV 236 F + HT + +R NP S+ G I + G + + D + Sbjct: 218 FDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFA 277 Query: 237 AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVG 280 + +SPDG KIA+ +D+ ++I+ T K+ + Sbjct: 278 KCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGKLMRVFDES 321 Score = 66.4 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 50/282 (17%), Positives = 93/282 (32%), Gaps = 48/282 (17%) Query: 305 FINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD-ISTGISNRVFP 363 + N S+ + Y H IT + + + +A +GH+ W I GI Sbjct: 71 RVYLDNLPSASMYERSYMHRDVITHVVCTKTD-FIITASHDGHVKFWKKIEEGIEFVKHF 129 Query: 364 DVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADG 423 H +I I +S+G LF DD V V+ KL P G Sbjct: 130 RSHLGVIESIAVSSEGALFCSVGDDKAMKV---FDVVNFDMINMLKLGYFP--------G 178 Query: 424 DIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVS 483 C ++ V S S+ D + G + +H++ Sbjct: 179 QCEWIYCPGDA-------ISSVAASEKSTGKIFIYDGR-----GDNQPLHIFD------- 219 Query: 484 EVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPY-SVANNFELAHTNSWTFHTA----- 537 +H + +T + + +V++D+S + + + ++ +W + T Sbjct: 220 ----KLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYE 275 Query: 538 ------KVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPI 573 V +SPD ++AT D V ++ + Sbjct: 276 FAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGKLMRV 317 Score = 61.4 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 33/248 (13%), Positives = 71/248 (28%), Gaps = 27/248 (10%) Query: 267 NVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVN-PELG-SIDQVRYGHN 324 N+ + + + + + + +++ S +G + F E G + H Sbjct: 76 NLPSASMYERSYMHRDVITHVVCTKTD--FIITASHDGHVKFWKKIEEGIEFVKHFRSHL 133 Query: 325 KAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHAT--MITGIKTTSKGDLF 382 I +++ S++G S + + +D+ + + Sbjct: 134 GVIESIAVSSEGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPGDAISSV 193 Query: 383 TVSWDDHLKVVPAGGSGVDSSKAVANKLSSQP---------LGLAVSADGDIAVAACYKH 433 S K+ G G + + +KL + P VS+D + Sbjct: 194 AASEKSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGP 253 Query: 434 IAIYSHGKLTE------------VPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGAS 481 Y K + V S D + +A G D KV +++ Sbjct: 254 PHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGK 313 Query: 482 VSEVKTIV 489 + V Sbjct: 314 LMRVFDES 321 Score = 37.2 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 25/148 (16%), Positives = 44/148 (29%), Gaps = 30/148 (20%) Query: 24 LGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIY---------------TEHSHQTTVAKTS 68 LG P + YC G ++ +V + +I+ H+ T + + Sbjct: 173 LGYFPGQCEWIYCPGDAISSVAASEKSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLN 232 Query: 69 PSGYYCASGDVHGNVRIW-------------DTTQTTHILKTTIPVFSGPVKDISWDSES 115 P S D G + W + T + + + Sbjct: 233 PVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDG 292 Query: 116 KRIAAVGEGRERFGHVFLFDTGTSNGNL 143 K+IA +G R+ +F F TG Sbjct: 293 KKIATIGSDRK--VRIFRFVTGKLMRVF 318 Score = 36.0 bits (81), Expect = 0.050, Method: Composition-based stats. Identities = 13/80 (16%), Positives = 23/80 (28%), Gaps = 1/80 (1%) Query: 530 NSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW 589 H + V + T S D V W + + +H + + Sbjct: 84 ERSYMHRDVITHV-VCTKTDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVS 142 Query: 590 LNETTIVSAGQDSNIKFWNV 609 S G D +K ++V Sbjct: 143 SEGALFCSVGDDKAMKVFDV 162 >5CXC-A nrPDB Length = 510 Score = 94.9 bits (234), Expect = 9e-20, Method: Composition-based stats. Identities = 52/310 (16%), Positives = 98/310 (31%), Gaps = 49/310 (15%) Query: 67 TSPSGYYCASGDVHGNVRIWDTTQTTHIL--KTTIPVFSGPVKDISWDSESKRIAAVGEG 124 P S G +RIW+ + + + + +K + + + G Sbjct: 154 VQPGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDRL---ASAG 210 Query: 125 RERFGHVF-----LFDTGTSNGNLT--GQARAMNSVDFKPSRPFRIISGSDDNTVAIFEG 177 +R V+ TG L G +++ +D I++ S D + + Sbjct: 211 MDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVD-GHSKHILTASADGAIGFWSA 269 Query: 178 PPFKFK----STFGE-HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDS 232 S H V + ST G + L++ Sbjct: 270 SKASAPEPDASLLPGAH------VSKRRKATSSVSTAQRGPLGLWSI------------- 310 Query: 233 LKNVAHSGSVFGLTWSPDGTKIA-SASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGII 291 H+ + P +A SAS D T++ ++ T +V T+ + + Sbjct: 311 -----HTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTR 365 Query: 292 W--TKQALVSISANGFINFVNPELGSI---DQVRYGHNKAITALSSSADGKT-LFSADAE 345 T L + ++ I V+P S GH + +LS S + + L S + Sbjct: 366 AGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHD 425 Query: 346 GHINSWDIST 355 G WD+ + Sbjct: 426 GTCRVWDLRS 435 Score = 92.2 bits (227), Expect = 6e-19, Method: Composition-based stats. Identities = 67/442 (15%), Positives = 130/442 (29%), Gaps = 92/442 (20%) Query: 146 QARAMNSVDF----KPSRPF---------------RIISGSDDNTVAIFEGPPFKFKST- 185 +++VD P+ + R++S S D + I+ ++ Sbjct: 125 HDDWVSAVDVLSATSPAGRWSSAANSSAAVQPGQERVLSASYDGLLRIWNASGSVIATSP 184 Query: 186 ---FGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSV 242 G HT + + ++ AS G D T+ ++ + +L+ H+GSV Sbjct: 185 SGSHGGHTASIKAAKFL-TSDRLASAGMDRTVRVWKYTESDHFTGELKPTLELYGHTGSV 243 Query: 243 FGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISA 302 L I +ASAD I W + K P + + + + VS + Sbjct: 244 DWLDVDGHSKHILTASADGAIGFW--SASKASAPEPDASLLPGAHVSKRRKATSSVSTAQ 301 Query: 303 NGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLF-SADAEGHINSWDISTGISNRV 361 G + + H TA +T+ SA + + + D++TG Sbjct: 302 RGPLGLWSI-----------HTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVST 350 Query: 362 FPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSA 421 H + S A+ ++ PL A ++ Sbjct: 351 LTLTH--------------------------------PLLSLSALTRAGTTSPLLAAGTS 378 Query: 422 DGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQF-VAVGGQDSKVHVYKLSGA 480 I + A S L + ++ S + ++ + G D V+ L Sbjct: 379 ARHITMVDPRASSATTSVMTLR--GHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSV 436 Query: 481 SVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVA 540 + K ++ + + + ++ KV Sbjct: 437 RPA-TKEEGSLGGVSEPVYVIERESWASKGKKKR----------------PVAGDGCKVF 479 Query: 541 CVSWSPDNVRLATGSLDNSVIV 562 V W + +G D V V Sbjct: 480 SVVWDKLG--IFSGGEDKKVQV 499 Score = 84.2 bits (206), Expect = 2e-16, Method: Composition-based stats. Identities = 60/333 (18%), Positives = 102/333 (30%), Gaps = 67/333 (20%) Query: 249 PDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW---TKQALVSISANGF 305 P ++ SAS D ++IWN A+ V T P G+ T L S + Sbjct: 156 PGQERVLSASYDGLLRIWN-ASGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRT 214 Query: 306 INFVNPELG-------SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGIS 358 + YGH ++ L K + +A A+G I W S + Sbjct: 215 VRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASA 274 Query: 359 NRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLA 418 P+ A+++ G + + + + PLGL Sbjct: 275 ----PEPDASLLPGAHVSKRRKATSS----------------------VSTAQRGPLGLW 308 Query: 419 VSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVA-VGGQDSKVHVYKL 477 + ++ + VA QD V L Sbjct: 309 SI--------------------------HTAPATAAIFDPRDRTVAYSASQDHTVRTLDL 342 Query: 478 SGASVSEVKTIVHPA-EITSVA-FSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFH 535 + V T+ HP ++++ L A +R + + + H Sbjct: 343 TTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGH 402 Query: 536 TAKVACVSWSPDNVR-LATGSLDNSVIVWNMNK 567 KV +S SP+N L +GS D + VW++ Sbjct: 403 ANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRS 435 Score = 75.3 bits (183), Expect = 7e-14, Method: Composition-based stats. Identities = 42/334 (12%), Positives = 91/334 (27%), Gaps = 48/334 (14%) Query: 29 AGDKIQYCNGTSVYTVPVGSLTD--------TEIYTEHSHQTTVAKTSPSGYYCASGDVH 80 D++ V + +D T H+ + + Sbjct: 202 TSDRLASAGMDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASAD 261 Query: 81 GNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSN 140 G + W ++ + + V +R A + G + L+ Sbjct: 262 GAIGFWSASKASAPEPDASLLPGAHVS-------KRRKATSSVSTAQRGPLGLWSI---- 310 Query: 141 GNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNP 200 + F P S S D+TV + + ST + Sbjct: 311 -----HTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTR 365 Query: 201 DGS---LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP-DGTKIAS 256 G+ L A+ I + + + T + H+ V L+ SP + + S Sbjct: 366 AGTTSPLLAAGTSARHITMVDPRASSATTSV----MTLRGHANKVVSLSPSPENEYSLVS 421 Query: 257 ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSI 316 S D T ++W++ +++ + + +I + G Sbjct: 422 GSHDGTCRVWDLRSVRPATKEEGSLGGVSEPVYVIERESW--------------ASKGKK 467 Query: 317 DQVRYGHNKAITALSSSADGKTLFSADAEGHINS 350 + G + ++ G +FS + + Sbjct: 468 KRPVAGDGCKVFSVVWDKLG--IFSGGEDKKVQV 499 Score = 66.4 bits (160), Expect = 4e-11, Method: Composition-based stats. Identities = 42/284 (14%), Positives = 78/284 (27%), Gaps = 24/284 (8%) Query: 339 LFSADAEGHINSWDIS---TGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPA 395 + SA +G + W+ S S H I K + L + D ++V Sbjct: 161 VLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRTVRVWKY 220 Query: 396 GGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIA-IYSHGKLTEVPISYNSSCV 454 S +L P G + H I + + S Sbjct: 221 TES-----DHFTGELK--PTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKAS 273 Query: 455 ALSNDKQFV--AVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSN-NGAFLVATDQ 511 A D + A + K + +H A T+ F + + Q Sbjct: 274 APEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQ 333 Query: 512 SRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP----DNVRLATGSLDNSVIVWNMNK 567 V + ++ T + +S + LA G+ + + + Sbjct: 334 DHTVRTLDLTTGQVVSTLTL----THPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRA 389 Query: 568 PSDH-PIIIKGAHAMSSVNSVIWLNETT-IVSAGQDSNIKFWNV 609 S ++ HA V+ +VS D + W++ Sbjct: 390 SSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDL 433 Score = 42.6 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 13/64 (20%), Positives = 25/64 (39%), Gaps = 1/64 (1%) Query: 546 PDNVRLATGSLDNSVIVWNMNKPSDHPIIIK-GAHAMSSVNSVIWLNETTIVSAGQDSNI 604 P R+ + S D + +WN + +S+ + +L + SAG D + Sbjct: 156 PGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRTV 215 Query: 605 KFWN 608 + W Sbjct: 216 RVWK 219 >6BX3-B nrPDB Length = 412 Score = 94.2 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 62/353 (17%), Positives = 120/353 (33%), Gaps = 27/353 (7%) Query: 174 IFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSL 233 + + P K T ++++P G A +G +V+Y+ V Sbjct: 10 VLKEHPEKLTHTIENPL-RTECLQFSPCGDYLALGCANGALVIYDMDTFRPICV---PGN 65 Query: 234 KNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWT 293 AH + + WSPDG + ++S D +IK+W+++ P E + IW Sbjct: 66 MLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSK-------PSKPLKEIRFDSPIWG 118 Query: 294 KQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 Q L A + S V N + +L S +D K L S G++ + Sbjct: 119 CQWL---DAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTV 175 Query: 354 STGISNRVFPDVHATMITGIKTTSKGDLFTV-SWDDHLKVVPAGGSGVDSSKAVANKLSS 412 T N + + K S + S + + + N Sbjct: 176 HTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDR 235 Query: 413 QPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQ--FVAV--GGQ 468 +S D + + + K +V +C+ SN+ VA G Sbjct: 236 TIRQYEISIDDENSAVE------LTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSS 289 Query: 469 DSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVA-TDQSRKVIPYSV 520 ++++++ + ++ V E+ + + +V+ +S V +SV Sbjct: 290 AHELYIWETTSGTLVRVLE-GAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 341 Score = 80.3 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 43/318 (13%), Positives = 94/318 (29%), Gaps = 29/318 (9%) Query: 20 TAVVLGNTPAGDKIQYCNGTSVYTVPVGS-----LTDTEIYTEHSHQTTVAKTSPSGYYC 74 L +P GD + + + H T SP G Sbjct: 27 RTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLL 86 Query: 75 ASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLF 134 + ++++WD ++ + LK F P+ W +R+ E +V F Sbjct: 87 LTSSRDWSIKLWDLSKPSKPLKEI--RFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDF 144 Query: 135 D----------TGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTV---AIFEGPPFK 181 + + T + P II G+ + + Sbjct: 145 SNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTE 204 Query: 182 FKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGV---DGTKTGVFEDDSLKNVAH 238 + + + + + +G A D TI Y + + + + ++V + Sbjct: 205 CIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVIN 264 Query: 239 SGSVFGLTWSPD--GTKIAS--ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK 294 + +S + +AS S+ + IW + + + + G E + + Sbjct: 265 KLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLE-GAEEELIDINWDFYS 323 Query: 295 QALVSISAN-GFINFVNP 311 ++VS G + + Sbjct: 324 MSIVSNGFESGNVYVWSV 341 Score = 72.6 bits (176), Expect = 5e-13, Method: Composition-based stats. Identities = 54/362 (14%), Positives = 111/362 (30%), Gaps = 51/362 (14%) Query: 268 VATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPEL----GSIDQVRYGH 323 + + T + + + L L ANG + + + + H Sbjct: 11 LKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAH 70 Query: 324 NKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFT 383 + IT+++ S DG+ L ++ + I WD+S + + I+ S ++ Sbjct: 71 VRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKP----------SKPLKEIRFDS--PIWG 118 Query: 384 VSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLT 443 W D + + +S V + + L +D + Sbjct: 119 CQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSD---------------EKQLSS 163 Query: 444 EVPISYNSSCVALSNDKQFVAVGGQDSKVHVYK----LSGASVSEVKTIVHPAEITSVAF 499 Y C + + VG + YK + +K + I + Sbjct: 164 TPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKIT--SSNIKHLIV 221 Query: 500 SNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHT--AKVACVSWS------PDNVRL 551 S NG L R + Y ++ + E + H + + W+ L Sbjct: 222 SQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYL 281 Query: 552 AT---GSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAG-QDSNIKFW 607 GS + + +W + ++ + +N + IVS G + N+ W Sbjct: 282 VASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMS--IVSNGFESGNVYVW 339 Query: 608 NV 609 +V Sbjct: 340 SV 341 >5BJS-A nrPDB Length = 605 Score = 93.8 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 40/186 (21%), Positives = 67/186 (36%), Gaps = 19/186 (10%) Query: 110 SWDSE---SKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISG 166 W + + + + G E V+ G L G +N + P+ P+ I S Sbjct: 139 CWSKDPITDQPLLCIA-GNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASA 197 Query: 167 SDDNTVAIF------EGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLY--- 217 SDD T+ I+ E P H+ + SV ++ +G S G D I L+ Sbjct: 198 SDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALP 257 Query: 218 ---NGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIAS-ASADKTIKIWNVATLKV 273 N ++ + H+ V + + G I S A + TI +W + Sbjct: 258 EFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFY--GDLILSRACHEDTIVLWRIEGFSS 315 Query: 274 EKTIPV 279 + IP Sbjct: 316 DDPIPG 321 Score = 76.1 bits (185), Expect = 5e-14, Method: Composition-based stats. Identities = 25/165 (15%), Positives = 59/165 (35%), Gaps = 15/165 (9%) Query: 459 DKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFL-VATDQSRKVIP 517 D+ + + G + V VY ++ + H I +A S ++ + + Sbjct: 147 DQPLLCIAGNEGNVKVYNVTEGKLYRTLV-GHGGGINDLATSPANPYIIASASDDTTIRI 205 Query: 518 YSVA---NNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM----NKPSD 570 +S+A H+ + V++ + + + D + +W + N+ + Sbjct: 206 WSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHME 265 Query: 571 HPIIIKGAH------AMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 PI+I H + V+ V + + + A + I W + Sbjct: 266 IPIVIYYPHFSSSEIHNNLVDCVAFYGDLILSRACHEDTIVLWRI 310 Score = 68.7 bits (166), Expect = 7e-12, Method: Composition-based stats. Identities = 25/189 (13%), Positives = 58/189 (30%), Gaps = 22/189 (11%) Query: 243 FGLTWSPD----GTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALV 298 WS D + A + +K++NV K+ +T+ + + Sbjct: 136 CASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIA 195 Query: 299 SISANGFINFVNP------ELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 S S + I + + GH+ + +++ +G+ + SA + IN W Sbjct: 196 SASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWA 255 Query: 353 ISTGISNRVFP------------DVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGV 400 + + + ++H ++ + L +D + + G Sbjct: 256 LPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFYGDLILSRACHEDTIVLWRIEGFSS 315 Query: 401 DSSKAVANK 409 D Sbjct: 316 DDPIPGPLD 324 Score = 61.8 bits (148), Expect = 8e-10, Method: Composition-based stats. Identities = 24/122 (19%), Positives = 45/122 (36%), Gaps = 12/122 (9%) Query: 498 AFSNN----GAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRL-A 552 +S + L V Y+V + H + ++ SP N + A Sbjct: 139 CWSKDPITDQPLLCIAGNEGNVKVYNVTEG---KLYRTLVGHGGGINDLATSPANPYIIA 195 Query: 553 TGSLDNSVIVWNMNKPS---DHPIIIKGAHAMSSVNSVIWLNE-TTIVSAGQDSNIKFWN 608 + S D ++ +W++ I+ G + SV + + ++SAG D I W Sbjct: 196 SASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWA 255 Query: 609 VP 610 +P Sbjct: 256 LP 257 Score = 56.8 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 34/209 (16%), Positives = 62/209 (29%), Gaps = 45/209 (21%) Query: 21 AVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYT---EHSHQTTVAKTSPSGYYC-AS 76 P D+ C + V V ++T+ ++Y H TSP+ Y AS Sbjct: 139 CW--SKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIAS 196 Query: 77 GDVHGNVRIWDT----TQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVF 132 +RIW + + S + +++ + + + G + + Sbjct: 197 ASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQ----VIN 252 Query: 133 LFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKF 192 L+ + + + V + P S S H Sbjct: 253 LW----ALPEFPNEHMEIPIVIYYPH-----FSSS-------------------EIHNNL 284 Query: 193 VHSVRYNPDGSLFAS-TGGDGTIVLYNGV 220 V V + G L S + TIVL+ Sbjct: 285 VDCVAFY--GDLILSRACHEDTIVLWRIE 311 Score = 45.2 bits (105), Expect = 8e-05, Method: Composition-based stats. Identities = 25/208 (12%), Positives = 63/208 (30%), Gaps = 48/208 (23%) Query: 327 ITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSW 386 + D L A EG++ ++++ G R + + + + + Sbjct: 139 CWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASAS 198 Query: 387 DDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVP 446 DD + + + QP + +G Sbjct: 199 DDTTIRIWSLAP----------EHEKQPCVCILGGEGH---------------------- 226 Query: 447 ISYNSSCVALSNDKQFVAVGGQDSKVHVYKL----SGASVSEV--------KTIVHPAEI 494 SY+ VA ++ ++V G D ++++ L + + + +H + Sbjct: 227 -SYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLV 285 Query: 495 TSVAFSNNGAFLVA-TDQSRKVIPYSVA 521 VAF G +++ ++ + + Sbjct: 286 DCVAFY--GDLILSRACHEDTIVLWRIE 311 Score = 34.1 bits (76), Expect = 0.17, Method: Composition-based stats. Identities = 10/91 (10%), Positives = 26/91 (28%), Gaps = 11/91 (12%) Query: 57 EHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILK-----------TTIPVFSGP 105 HS+ +G Y S + +W + + ++ + + Sbjct: 225 GHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNL 284 Query: 106 VKDISWDSESKRIAAVGEGRERFGHVFLFDT 136 V +++ + A E + F + Sbjct: 285 VDCVAFYGDLILSRACHEDTIVLWRIEGFSS 315 >3F3P-A nrPDB Length = 351 Score = 93.4 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 46/340 (13%), Positives = 101/340 (29%), Gaps = 40/340 (11%) Query: 56 TEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTH--ILKTTIPVFSGPVKDISWDS 113 + H G + A+ +++++ + T L + + I W S Sbjct: 8 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 67 Query: 114 --ESKRIAAVGEGRERFGHVFLFDTGTS-------NGNLTGQARAMNSVDFKPSR-PFRI 163 + IA+ + D L ++ SV F P+ ++ Sbjct: 68 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 127 Query: 164 ISGSDDNTVAIFE------GPPFKFKSTFG-------EHTKFVHSVRYNPD---GSLFAS 207 +D + +++ + S H + + + P A Sbjct: 128 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 187 Query: 208 TGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD-GTK---IASASADKTI 263 + + I+ G DG + K H + ++W+P G IA+ D I Sbjct: 188 SALEQAIIYQRGKDGKL-----HVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI 242 Query: 264 KIWNVATLK---VEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVR 320 +I+ + + + + D + Q + + + Sbjct: 243 RIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEH 302 Query: 321 YGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNR 360 HN + ++S + G L SA +G + W + + Sbjct: 303 DDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFK 342 Score = 77.6 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 50/358 (13%), Positives = 108/358 (30%), Gaps = 40/358 (11%) Query: 237 AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQ-LGIIWTKQ 295 H V + + G +A+ S+D+ IK++ + + R D + I W Sbjct: 9 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 68 Query: 296 A----LVSISANGFINFV--NPELGSIDQVRYGH-------NKAITALSSSAD--GKTLF 340 + S S + + +P+ R+ ++ ++ + G L Sbjct: 69 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 128 Query: 341 SADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGV 400 +G + +D R + + I + + Sbjct: 129 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANH---------LQSDFCLSWCPSR 179 Query: 401 DSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIA--IYSHGKLTEVPISYNSSCVALSN 458 S + +A Q + DG + VAA I S + Y Sbjct: 180 FSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWY--------- 230 Query: 459 DKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPY 518 Q +A G +D ++ ++K+ +S + + S + Sbjct: 231 --QLIATGCKDGRIRIFKI-TEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEK 287 Query: 519 -SVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIII 575 + +N ++ + H +V VSW+ L++ D V +W ++ + Sbjct: 288 AELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMS 345 Score = 73.4 bits (178), Expect = 3e-13, Method: Composition-based stats. Identities = 43/328 (13%), Positives = 95/328 (28%), Gaps = 74/328 (22%) Query: 26 NTPAGDKIQYCNGTSVYTV-----PVGSLTDTEIYTEHSHQTTVAKT-SPS-GYYCASGD 78 G + C+ V + ++ + H SP G AS Sbjct: 19 YDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASAS 78 Query: 79 VHGNVRIWDTTQTTHILKT-------TIPVFSGPVKDISWDSESKRIAAVGEGRERFGHV 131 V++W+ T+ G + + + + G + + Sbjct: 79 YDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRL 138 Query: 132 FL---------FDTGTSNGNLT----GQARAMNSVDFKPSR--PFRIISGSDDNTVAIFE 176 + + + L+ ++ + + PSR P ++ + + + Sbjct: 139 YDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQR 198 Query: 177 GPPFKF--KSTFGEHTKFVHSVRYNP----DGSLFASTGGDGTIVLY------------- 217 G K + H + S+ + P L A+ DG I ++ Sbjct: 199 GKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEE 258 Query: 218 ----------------NGVDGTKTGVFEDDSLKN----------VAHSGSVFGLTWSPDG 251 + + + E L++ H+G V+ ++W+ G Sbjct: 259 SLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTG 318 Query: 252 TKIASASADKTIKIWNVATLKVEKTIPV 279 T ++SA D +++W K + V Sbjct: 319 TILSSAGDDGKVRLWKATYSNEFKCMSV 346 Score = 60.7 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 50/339 (14%), Positives = 112/339 (33%), Gaps = 45/339 (13%) Query: 315 SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPD---VHATMIT 371 + GH+ + + G+ + + ++ HI + + SN D H + I Sbjct: 2 HMQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIV 61 Query: 372 GIKTTSKGD---LFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQP-------------- 414 I S + + S+D +K+ + S NKL + Sbjct: 62 AIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPA 121 Query: 415 -LGLAVSADGDIAVAACY--------KHIAIYSHGKLTEVPISYNSS---CVALSN---- 458 LGL ++ G+ + Y + + S K+ +P + + C++ Sbjct: 122 HLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFS 181 Query: 459 DKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNN-GAF---LVATDQSRK 514 ++ + + ++ G K H + I S++++ + G + + + + Sbjct: 182 PEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGR 241 Query: 515 VIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLD-NSVIVWNMNKPSDHPI 573 + + + + ++ S D A G D N+ + + Sbjct: 242 IRIFKITEKLSPLASEESLTNSNMFDN---SADVDMDAQGRSDSNTEEKAELQSNLQVEL 298 Query: 574 IIKGAHAMSSVNSVIWL-NETTIVSAGQDSNIKFWNVPF 611 + + V SV W T + SAG D ++ W + Sbjct: 299 LSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATY 337 >4PSX-B nrPDB Length = 401 Score = 93.0 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 38/267 (14%), Positives = 83/267 (31%), Gaps = 21/267 (7%) Query: 20 TAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSP--SGYYCASG 77 A + P + + NG + S H S G SG Sbjct: 123 RARYMPQDP--NIVATINGQGTTFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLL-SG 179 Query: 78 DVHGNVRIWDTTQT---THILKTTIPVFSGPVKDISW-DSESKRIAAVGEGRERFGHVFL 133 V +W+ T ++T + S + D W + V E + Sbjct: 180 SDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSED--SLLKIND 237 Query: 134 FDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFK-FKSTFGEHTKF 192 + + + N++ F + + D+ V +++ K H Sbjct: 238 VRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDA 297 Query: 193 VHSVRYNPD-GSLFASTGGDGTIVLYNGVDGTKTGVFEDDS-------LKNVAHSGSVFG 244 V+++ ++ + S+G D +++++ +D + + H SV Sbjct: 298 VNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVND 357 Query: 245 LTWSPDGTKI-ASASADKTIKIWNVAT 270 +P + ASA + +++W + Sbjct: 358 FDLNPQIPWLVASAEEENILQVWKCSH 384 Score = 83.0 bits (203), Expect = 4e-16, Method: Composition-based stats. Identities = 51/306 (16%), Positives = 103/306 (33%), Gaps = 45/306 (14%) Query: 102 FSGPVKDISWDSESKRIAAVGEGRERFGHVFLF-DTGTSNGNLTGQARAMNSVDFKPSRP 160 + + + I A G+ G FL+ + L ++ F Sbjct: 117 HEEEITRARYMPQDPNIVATINGQ---GTTFLYSRSEGLQSTLKFHKDNGYALSFSTLVK 173 Query: 161 FRIISGSDDNTVAIFE----GPPFKFKSTFGE-HTKFVHSVRYNP-DGSLFASTGGDGTI 214 R++SGSDD+TVA++E G P K T+ + H+ ++ +++ + LF + D + Sbjct: 174 GRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLL 233 Query: 215 VLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGT-KIASASADKTIKIWNVATLKV 273 + + T + V L +S + +A+A D + ++++ +K Sbjct: 234 KINDVRANNTT-------IDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKE 286 Query: 274 EKTIPVGTRIEDQQLGIIWTKQA-LVSISANGFINFVNPEL--------------GSIDQ 318 G L +VS ++ + + + + Sbjct: 287 PLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIM 346 Query: 319 VRYGHNKAITALSSSADGKTL-FSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTS 377 V GH ++ + L SA+ E + W S H+ I G Sbjct: 347 VHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCS-----------HSLPIVGGPPKV 395 Query: 378 KGDLFT 383 D+ + Sbjct: 396 NKDIIS 401 Score = 70.3 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 43/299 (14%), Positives = 90/299 (30%), Gaps = 62/299 (20%) Query: 293 TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSA--DGKTLFSADAEGHINS 350 + +I+ G + G + H ALS S G+ L S + + Sbjct: 130 DPNIVATINGQGTTFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKGRLL-SGSDDHTVAL 187 Query: 351 WDISTG----ISNRVFPDVHATMITGIKTTS-KGDLFTVSWDDHLKVVPAGGSGVDSSKA 405 W++ +G R + D+H+ +I K + DLF +D L + + + Sbjct: 188 WEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTT--- 244 Query: 406 VANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALS-NDKQFVA 464 + V + +A S + +A Sbjct: 245 ------------------------------------IDTVKCPQPFNTLAFSHHSSNLLA 268 Query: 465 VGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAF-LVATDQSRKVIPYSVANN 523 G DS V++Y L H + ++ FS + +V++ +++ + + Sbjct: 269 AAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQI 328 Query: 524 FELAHTN-----------SWTFHTAKVACVSWSPDNVRLATGSLDNSV-IVWNMNKPSD 570 + H + V +P L + + ++ VW + Sbjct: 329 GAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLP 387 Score = 66.0 bits (159), Expect = 5e-11, Method: Composition-based stats. Identities = 59/317 (18%), Positives = 111/317 (35%), Gaps = 59/317 (18%) Query: 311 PELGSIDQVRYGHNKAITALSSSA-DGKTLFSADAEGHINSWDISTGISNRVFPDVHATM 369 P +Y H + IT D + + + +G + S G + H Sbjct: 105 PRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTTFLYSRSEG--LQSTLKFHKDN 162 Query: 370 ITGIKTTS--KGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAV 427 + ++ KG L + DDH + GSG D +K Sbjct: 163 GYALSFSTLVKGRLLS-GSDDHTVALWEVGSGGDPTKP---------------------- 199 Query: 428 AACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKT 487 + + H + +N + K +DS + + + + + + T Sbjct: 200 VRTWNDL----HSDIINDNKWHNFN-------KDLFGTVSEDSLLKINDVRANN-TTIDT 247 Query: 488 IVHPAEITSVAFSNNGA-FLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP 546 + P ++AFS++ + L A V Y + N E H S H V + +S Sbjct: 248 VKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMS--GHEDAVNNLEFST 305 Query: 547 --DNVRLATGSLDNSVIVWNMNKPSDHPI-----------IIKGAHAMSSVNSVIWLNE- 592 D V +++GS DN +++W++ + I+ A SSVN + Sbjct: 306 HVDGVVVSSGS-DNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQI 364 Query: 593 TTIVSAGQDSNI-KFWN 608 +V++ ++ NI + W Sbjct: 365 PWLVASAEEENILQVWK 381 Score = 57.2 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 22/155 (14%), Positives = 55/155 (35%), Gaps = 13/155 (8%) Query: 463 VAVGGQDSKVHVYKLSGA----SVSEVKTIVHPAEITSVAFSN-NGAFLVATDQSRKVIP 517 + G D V ++++ +H I + N N + + Sbjct: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 Query: 518 YSVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVWNMNKPSDHPIIIK 576 V N T +++S + LA +D+ V ++++ + + Sbjct: 236 NDVRANNTTIDTVKCP---QPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEP--LHH 290 Query: 577 GAHAMSSVNSVIWLN--ETTIVSAGQDSNIKFWNV 609 + +VN++ + + +VS+G D+ + W++ Sbjct: 291 MSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDL 325 >5FA5-B nrPDB Length = 367 Score = 91.9 bits (226), Expect = 8e-19, Method: Composition-based stats. Identities = 40/299 (13%), Positives = 94/299 (31%), Gaps = 17/299 (5%) Query: 61 QTTVAKTSPSGYYCASGD------VHGNVRIWDTTQTTHILKTTIPVFS--GPVKDISWD 112 Q A+ G G++ ++ V D++W Sbjct: 55 QLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWV 114 Query: 113 SESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTV 172 E + A G + +T + + + S S + +SGS D + Sbjct: 115 GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 174 Query: 173 AIFEGPPFKFKSTFGEHTKFVHSVRYNPD-GSLFASTGGDGTIVLYNGVDGTKTGVFEDD 231 +++ S++ H V V +P S+F S D I+L++ Sbjct: 175 KVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 234 Query: 232 SLKNVAHSGSVFGLTWSPDGTKIASASADK-TIKIWNVATLKVEKTIPVGTRIEDQQLGI 290 + + L W P +++ + T+ + + + + V ++ + Sbjct: 235 APGYLP-----TSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFS 289 Query: 291 IWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSA-DGKTLFSADAEGHI 348 + L S+S + + ++ L + + H + + S + L + + + Sbjct: 290 PHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 81.8 bits (200), Expect = 8e-16, Method: Composition-based stats. Identities = 34/215 (15%), Positives = 78/215 (36%), Gaps = 21/215 (9%) Query: 56 TEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS-E 114 EH + SG SG +++WD Q ++ ++ + V ++ + Sbjct: 147 YEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQ--VVLSSYRAHAAQVTCVAASPHK 204 Query: 115 SKRIAAVGEGRERFGHVFLFDTGTSN-GNLTGQARAM---NSVDFKPSRPFRIISGSDDN 170 + E + L+DT + G + S+ + P + + G ++ Sbjct: 205 DSVFLSCSEDN----RILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENG 260 Query: 171 TVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDG-SLFASTGGDGTIVLYNGVDGTKTGVFE 229 TV++ + + H++ V + ++P AS D ++ + + Sbjct: 261 TVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSS--------L 312 Query: 230 DDSLKNVAHSGSVFGLTWSP-DGTKIASASADKTI 263 + ++ AH V TWSP + + + + D + Sbjct: 313 SELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 71.4 bits (173), Expect = 9e-13, Method: Composition-based stats. Identities = 52/348 (14%), Positives = 101/348 (29%), Gaps = 57/348 (16%) Query: 228 FEDDSLKNVAHSGSVFGLTWSPDGTKIA-SASADKTIK---IW---NVATLKVEKTIPVG 280 + + + DG + ++S +W + E G Sbjct: 42 WNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAG 101 Query: 281 TRIEDQQLGIIWTKQ-ALVSISANGFINFVNPELGSIDQV----RYGHNKAITALSSSAD 335 + E + W + ++ S +G + + V +Y H+ ++ +S + Sbjct: 102 VQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSS 161 Query: 336 GKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPA 395 G S + I WD++ HA +T + + D Sbjct: 162 GTQAVSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSV------------- 207 Query: 396 GGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVA 455 L+ S D I + G Y + +A Sbjct: 208 --------------------FLSCSEDNRILLWDTRCPKPASQIGCSAP---GYLPTSLA 244 Query: 456 LSNDKQFVAV-GGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNG-AFLVATDQSR 513 + V V G ++ V + S + + VH +T + FS + FL + + Sbjct: 245 WHPQQSEVFVFGDENGTVSLVDTKSTSCV-LSSAVHSQCVTGLVFSPHSVPFLASLSEDC 303 Query: 514 KVIPYSVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSV 560 + L+ H V +WSP ++ L T D+ V Sbjct: 304 SLAVLD----SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 62.6 bits (150), Expect = 5e-10, Method: Composition-based stats. Identities = 23/112 (20%), Positives = 48/112 (42%), Gaps = 7/112 (6%) Query: 463 VAVGGQDSKVHVYKLSGASVSEVKTIV---HPAEITSVAFSNNGAFLVATDQSRKVIPYS 519 + V V +++L V H +++V+ ++G V+ + + + Sbjct: 119 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 178 Query: 520 VANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVWNMNKPSD 570 +A L+ S+ H A+V CV+ SP + + S DN +++W+ P Sbjct: 179 LAQQVVLS---SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKP 227 Score = 50.6 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 20/120 (16%), Positives = 43/120 (35%), Gaps = 5/120 (4%) Query: 491 PAEITSVAFSNNGAFLVATDQSRKVIPYSV-ANNFELAHTNSWTFHTAKVACVSWSPDNV 549 A + + + ++ S V + + N + H V+ VS Sbjct: 105 EAGVADLTWV-GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT 163 Query: 550 RLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLN-ETTIVSAGQDSNIKFWN 608 + +GS D + VW++ + + AHA + ++ +S +D+ I W+ Sbjct: 164 QAVSGSKDICIKVWDLAQQVV--LSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 221 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 22/173 (12%), Positives = 46/173 (26%), Gaps = 12/173 (6%) Query: 13 LPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPS-G 71 + + +V L + + + +G + T P Sbjct: 198 VAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPT-------SLAWHPQQS 250 Query: 72 YYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHV 131 GD +G V + DT T+ +L + V S V + + S A + Sbjct: 251 EVFVFGDENGTVSLVDTKSTSCVLSS--AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL 308 Query: 132 FLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKS 184 + + + + P + + D+ V P + Sbjct: 309 D--SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPA 359 Score = 35.6 bits (80), Expect = 0.072, Method: Composition-based stats. Identities = 16/78 (20%), Positives = 33/78 (42%), Gaps = 7/78 (8%) Query: 536 TAKVACVSWSPDNVRLATGSLDNSVIVWNMNKP----SDHPIIIKGAHAMSSVNSVIWLN 591 A VA ++W + S +V +W +++ + +S+V+ + + Sbjct: 105 EAGVADLTW-VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVL--SS 161 Query: 592 ETTIVSAGQDSNIKFWNV 609 T VS +D IK W++ Sbjct: 162 GTQAVSGSKDICIKVWDL 179 >6E29-D nrPDB Length = 345 Score = 91.5 bits (225), Expect = 1e-18, Method: Composition-based stats. Identities = 60/392 (15%), Positives = 130/392 (33%), Gaps = 61/392 (15%) Query: 131 VFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHT 190 + + +N +G + V F + + SG D TV I++ H+ Sbjct: 12 LQDYPENITNTIRSGHS---TCVRFN-RKGDFLASGRVDGTVVIWDLETMGVARKLRGHS 67 Query: 191 KFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD 250 K + S+ ++ G S ++L++ DG + + V V+G P Sbjct: 68 KNITSLSWSRCGRYLLSACQGWKVILWDLQDGKR--------YREVRFRAPVYGAELHPW 119 Query: 251 GTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVN 310 +A+ L ++ + V + ++ + S + + Sbjct: 120 NHHQFAAA------------LFEDQPMLVDITEPVEVRYVLPSVPKRTSTETDPALREKQ 167 Query: 311 PELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMI 370 + + TA+ +A G L + +G +N D T + + +I Sbjct: 168 AKEDAKHMT--------TAIVYTASGDHLLAGTTKGRLNIIDARTRE-IIYSEKIASGII 218 Query: 371 TGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAAC 430 T ++ T G V+ D + P A D D Sbjct: 219 TTLRLTESGRELLVNAQDRIIRTFI-----------------VPNLSAADLDPDT----- 256 Query: 431 YKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDS-KVHVYKLSGASVSEVKTIV 489 I + K +V + + VA S ++VA ++ ++++++ S+ + Sbjct: 257 ---IQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERGHGSLVRMLEGP 313 Query: 490 HPAEITSVAFSNNGAFLVATD-QSRKVIPYSV 520 E + + + A L A ++ ++ +SV Sbjct: 314 -KEEQGVIEWHPHRALLAACGLETGRINIWSV 344 Score = 83.0 bits (203), Expect = 3e-16, Method: Composition-based stats. Identities = 46/334 (13%), Positives = 103/334 (30%), Gaps = 51/334 (15%) Query: 59 SHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRI 118 S +T + + G + ASG V G V IWD T + + S + +SW + + Sbjct: 25 SGHSTCVRFNRKGDFLASGRVDGTVVIWDLE--TMGVARKLRGHSKNITSLSWSRCGRYL 82 Query: 119 AAVGEGRERFGHVFLFDTGTSNGNLTGQ-ARAMNSVDFKPSRPFRIISGSDDNTVAIFEG 177 + +G V L+D + + + P + + ++ + + Sbjct: 83 LSACQG----WKVILWDLQDGKRYREVRFRAPVYGAELHPWNHHQFAAALFEDQPMLVDI 138 Query: 178 PPF----------------------KFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIV 215 + K + ++ Y G + G + Sbjct: 139 TEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLN 198 Query: 216 LYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEK 275 + + + S G + L + G ++ + D+ I+ + V L Sbjct: 199 IIDARTREIIYSEKIAS-------GIITTLRLTESGRELLVNAQDRIIRTFIVPNLSAAD 251 Query: 276 ------TIPVGTRIED-------QQLGIIWTKQALVSISANGF-INFVNPELGSIDQVRY 321 +P+ + +D + T + + + + N + GS+ ++ Sbjct: 252 LDPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERGHGSLVRMLE 311 Query: 322 GHNKAITALSSSADGKTLFSADAE-GHINSWDIS 354 G + + L + E G IN W ++ Sbjct: 312 GPKEEQGVIEWHPHRALLAACGLETGRINIWSVT 345 Score = 70.3 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 43/324 (13%), Positives = 91/324 (28%), Gaps = 34/324 (10%) Query: 19 GTAVVLGNTPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASG 77 G + + GD + + + ++ HS T S G Y S Sbjct: 26 GHSTCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRYLLSA 85 Query: 78 DVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFL---- 133 V +WD + F PV + A ++ V + Sbjct: 86 CQGWKVILWDLQDGKRYREV---RFRAPVYGAELHPWNHHQFAAALFEDQPMLVDITEPV 142 Query: 134 ----------------FDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEG 177 D A+ M + + +++G+ + I + Sbjct: 143 EVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNIIDA 202 Query: 178 PPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 + + + + ++R G D I + + + + D + Sbjct: 203 RTREIIYSEKIASGIITTLRLTESGRELLVNAQDRIIRTFIVPNLSAADLDPDTIQLPLE 262 Query: 238 HS--GSVFGLTW-----SPDGTKIASASADKT-IKIWNVATLKVEKTIPVGTRIEDQQLG 289 H V L+W S G +A+++ + + IW + + + G + E + Sbjct: 263 HKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERGHGSLVRMLE-GPKEEQGVIE 321 Query: 290 IIWTKQALVSISAN-GFINFVNPE 312 + L + G IN + Sbjct: 322 WHPHRALLAACGLETGRINIWSVT 345 Score = 68.4 bits (165), Expect = 9e-12, Method: Composition-based stats. Identities = 29/136 (21%), Positives = 59/136 (43%), Gaps = 6/136 (4%) Query: 441 KLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFS 500 +T S +S+CV + F+A G D V ++ L V+ K H ITS+++S Sbjct: 18 NITNTIRSGHSTCVRFNRKGDFLASGRVDGTVVIWDLETMGVAR-KLRGHSKNITSLSWS 76 Query: 501 NNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNS 559 G +L++ Q KVI + + + A V P ++ + A ++ Sbjct: 77 RCGRYLLSACQGWKVILWDLQDGKRYREVRF----RAPVYGAELHPWNHHQFAAALFEDQ 132 Query: 560 VIVWNMNKPSDHPIII 575 ++ ++ +P + ++ Sbjct: 133 PMLVDITEPVEVRYVL 148 Score = 46.4 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 18/94 (19%), Positives = 39/94 (41%), Gaps = 7/94 (7%) Query: 517 PYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIK 576 Y + + E + H+ CV ++ LA+G +D +V++W++ K Sbjct: 9 DYLLQDYPENITNTIRSGHS---TCVRFNRKGDFLASGRVDGTVVIWDLETMGVAR---K 62 Query: 577 GAHAMSSVNSVIWLN-ETTIVSAGQDSNIKFWNV 609 ++ S+ W ++SA Q + W++ Sbjct: 63 LRGHSKNITSLSWSRCGRYLLSACQGWKVILWDL 96 Score = 38.7 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 28/176 (15%), Positives = 55/176 (31%), Gaps = 16/176 (9%) Query: 17 ARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEH--SHQTTVAKTSPSGYYC 74 A+ + T +GD + + + + T IY+E S T + + SG Sbjct: 172 AKHMTTAIVYTASGDHLLAGTTKGRLNI-IDARTREIIYSEKIASGIITTLRLTESGREL 230 Query: 75 ASGDVHGNVRIW--------DTTQTTHILKTTIPVFSGPVKDISWDSESKRIA--AVGEG 124 +R + D T L F V +SW+ + V Sbjct: 231 LVNAQDRIIRTFIVPNLSAADLDPDTIQLPLEHK-FQDVVNRLSWNHVAFSATGEYVAAS 289 Query: 125 RERFGHVFLFD--TGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP 178 +++++ G+ L G +++ P R G + + I+ Sbjct: 290 TYNNHELYIWERGHGSLVRMLEGPKEEQGVIEWHPHRALLAACGLETGRINIWSVT 345 >2PM9-A nrPDB Length = 416 Score = 90.3 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 58/403 (14%), Positives = 126/403 (31%), Gaps = 33/403 (8%) Query: 57 EHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESK 116 H + + SG A+ ++ +W D+ W +K Sbjct: 21 SHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHNNK 80 Query: 117 RIAAVGE--GRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAI 174 IA + E + + S + + ++ +V F + + SG ++ + I Sbjct: 81 IIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFI 140 Query: 175 FEGPPFKFKSTFGEHT-----------KFVHSVRYNPDGSL-FASTGGDGTIVLYNGVDG 222 ++ K + +T V S+ +N + FAS G +++ Sbjct: 141 WDMN--KCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAK 198 Query: 223 TKTGVFEDDSLKNVAHSGSVFGLTWSP-DGTKIASASA---DKTIKIWNVATLKV-EKTI 277 + S N + + W P + T++A+A+ D +I IW++ +T+ Sbjct: 199 KEVIHLSYTS-PNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTL 257 Query: 278 PVGTRIEDQQLGIIW-TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADG 336 G + L + L+S + + NPE + + Sbjct: 258 NQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPARGNWCFKTKFAPEA 317 Query: 337 KTLFS-ADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPA 395 LF+ A + I + ++ T+ T + + T W++ + Sbjct: 318 PDLFACASFDNKI---------EVQTLQNLTNTLDEQETETKQQESETDFWNNVSREESK 368 Query: 396 GGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYS 438 V +A P + + K ++I + Sbjct: 369 EKPSVFHLQAPTWYGEPSPAAHWAFGGKLVQITPDGKGVSITN 411 Score = 63.0 bits (151), Expect = 4e-10, Method: Composition-based stats. Identities = 32/166 (19%), Positives = 70/166 (42%), Gaps = 19/166 (11%) Query: 461 QFVAVGGQDSKVHVYKLS----GASVSEVKTIVHP----AEITSVAFSNN-GAFLVATDQ 511 +A GG + ++ ++ ++ S T E+ S+A++ + + Sbjct: 127 NVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGS 186 Query: 512 SRKVIPYSVANNFELAH---TNSWTFHTAKVACVSWSPDNVR---LATGS-LDNSVIVWN 564 S + + E+ H T+ + +++ V W P N ATGS D S+++W+ Sbjct: 187 SNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWD 246 Query: 565 MNKPSDHPIIIKGAHAMSSVNSVIW--LNETTIVSAGQDSNIKFWN 608 + + P+ + S+ W +E ++S+G+D+ + WN Sbjct: 247 LRNAN-TPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWN 291 Score = 62.6 bits (150), Expect = 5e-10, Method: Composition-based stats. Identities = 40/313 (12%), Positives = 91/313 (29%), Gaps = 31/313 (9%) Query: 323 HNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVH-ATMITGIKTTSKGDL 381 H+K +S + G + + + W + S + + + + + + Sbjct: 22 HDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHNNKI 81 Query: 382 FTVSWDDHLKVVPAGGSGVDSSKAVA----NKLSSQPLGLAVSADGDIAVAACYKHIAIY 437 + D+ + + ++ ++A + S + + D +A I I+ Sbjct: 82 IAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIW 141 Query: 438 SHGKLTEVPISYNSSCVALSNDK--------------QFVAVGGQDSKVHVYKLSGASVS 483 K TE P +Y S A G + ++ L Sbjct: 142 DMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEV 201 Query: 484 EVKTIVHPAE-----ITSVAFSN-NGAFLVAT---DQSRKVIPYSVANNFELAHTNSWTF 534 + P ++ V + N + D ++ + + N T + Sbjct: 202 IHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLN-QG 260 Query: 535 HTAKVACVSW-SPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNET 593 H + + W D L + DN+V++WN + ++ Sbjct: 261 HQKGILSLDWCHQDEHLLLSSGRDNTVLLWN-PESAEQLSQFPARGNWCFKTKFAPEAPD 319 Query: 594 TIVSAGQDSNIKF 606 A D+ I+ Sbjct: 320 LFACASFDNKIEV 332 Score = 51.8 bits (122), Expect = 9e-07, Method: Composition-based stats. Identities = 55/382 (14%), Positives = 115/382 (30%), Gaps = 65/382 (17%) Query: 188 EHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW 247 H K V G++ A+ D ++ L++ + + + ++ L W Sbjct: 21 SHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAAD-----SEKPIASLQVDSKFNDLDW 75 Query: 248 SPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK------QALVSIS 301 S + IA A + +++++ +T + I R + + K L S Sbjct: 76 SHNNKIIAGALDNGSLELY--STNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGG 133 Query: 302 ANGFINFVNPELGSIDQVRYGHN-----------KAITALSSSADGKTLF-SADAEGHIN 349 NG I + + + + + +L+ + +F SA + + Sbjct: 134 NNGEIFIWD--MNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFAS 191 Query: 350 SWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSW--DDHLKVVPAGGSGVDSSKAVA 407 WD+ V + + +GIK L V W + +V A GS D S + Sbjct: 192 IWDLKAKKE--VIHLSYTSPNSGIK----QQLSVVEWHPKNSTRVATATGSDNDPSILIW 245 Query: 408 NKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGG 467 + ++ ++ + + D+ + G Sbjct: 246 DLRNANTPLQTLNQGHQKGILSLDWCHQ-----------------------DEHLLLSSG 282 Query: 468 QDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVAT-DQSRKVIPYSVAN---- 522 +D+ V ++ A F+ L A K+ ++ N Sbjct: 283 RDNTVLLWNPESAEQLSQF-PARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQNLTNT 341 Query: 523 -NFELAHTNSWTFHTAKVACVS 543 + + T T VS Sbjct: 342 LDEQETETKQQESETDFWNNVS 363 Score = 49.5 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 31/154 (20%), Positives = 67/154 (43%), Gaps = 11/154 (7%) Query: 467 GQDSKVHVYKL-SGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYS-VANNF 524 DS + ++ L + S + ++ ++ + +S+N + + + YS N Sbjct: 42 STDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHNNKIIAGALDNGSLELYSTNEANN 101 Query: 525 ELAHTNSWTFHTAKVACVSWSPD-NVRLATGSLDNSVIVWNMNKPSDHP---IIIKGAHA 580 + ++ H++ V V ++ + LA+G + + +W+MNK ++ P + + Sbjct: 102 AINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQS 161 Query: 581 MSSVNSVIWLN-----ETTIVSAGQDSNIKFWNV 609 MSSV+ VI L SAG + W++ Sbjct: 162 MSSVDEVISLAWNQSLAHVFASAGSSNFASIWDL 195 >4OWR-A nrPDB Length = 339 Score = 89.9 bits (221), Expect = 3e-18, Method: Composition-based stats. Identities = 43/306 (14%), Positives = 87/306 (28%), Gaps = 74/306 (24%) Query: 147 ARAMNSVDFKPSR--PFRIISGSDDNTVAIFEGPP--FKFKSTFGEHTKFVHSVRYNPDG 202 ++ + F P +I+GS N V +E HT V V ++ DG Sbjct: 10 DDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDG 69 Query: 203 SLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW--SPDGTKIASASAD 260 S + D T +++ +++ H V + W +P+ + + + S D Sbjct: 70 SKVFTASCDKTAKMWDLSSN--------QAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWD 121 Query: 261 KTIKIWNVATLKVE----------------------------------------KTIPVG 280 KT+K W+ + + I Sbjct: 122 KTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESP 181 Query: 281 TRIEDQQLGIIWTKQA----LVSISANGFINFVN---PELGSIDQVRYGHNKA------- 326 + + + + I KQ S G + P + H Sbjct: 182 LKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAP 241 Query: 327 -----ITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDL 381 + ++ TL + ++G + WD + + I+ G++ Sbjct: 242 QDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQP-ISACCFNHNGNI 300 Query: 382 FTVSWD 387 F + Sbjct: 301 FAYASS 306 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 39/330 (11%), Positives = 104/330 (31%), Gaps = 39/330 (11%) Query: 51 DTEIYTEHSHQTTVAKTSPS---GYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVK 107 D E+ + SP G + +G +VR W+ + + + +GPV Sbjct: 2 DIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVL 61 Query: 108 DISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFR-IISG 166 D+ W + ++ + ++ + + + + ++ + + + +++G Sbjct: 62 DVCWSDDGSKVFTASCDK--TAKMWDLSSNQAI-QIAQHDAPVKTIHWIKAPNYSCVMTG 118 Query: 167 SDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTG 226 S D T+ ++ + + P + + +++Y + + Sbjct: 119 SWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYP---MAVVATAERGLIVYQLEN-QPSE 174 Query: 227 VFEDDSLKNVAHSGSVFGLTWSPDGTK----IASASADKTIKIW---------NVATLKV 273 +S H + D A S + + I + T K Sbjct: 175 FRRIESPLKHQHR----CVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKC 230 Query: 274 EKTIPVGTRIEDQQ-----LGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAIT 328 ++ T + L ++ ++G +F + + + + ++ I+ Sbjct: 231 HRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPIS 290 Query: 329 ALSSSADGKTLFSADAEGHINSWDISTGIS 358 A + +G A + +D S G Sbjct: 291 ACCFNHNGNIFAYASS------YDWSKGHE 314 Score = 82.6 bits (202), Expect = 5e-16, Method: Composition-based stats. Identities = 48/312 (15%), Positives = 101/312 (32%), Gaps = 40/312 (12%) Query: 277 IPVGTRIEDQQLGIIWTKQAL-----VSISANGFINFVNPELG--SIDQVRYGHNKAITA 329 I V + +D + ++ L ++ S + + +I + + H + Sbjct: 3 IEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLD 62 Query: 330 LSSSADGKTLFSADAEGHINSWDISTGISNRV-FPDVHATMITGIKTTSKGDLFTVSWDD 388 + S DG +F+A + WD+S+ + ++ D I IK + + T SWD Sbjct: 63 VCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDK 122 Query: 389 HLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIY------SHGKL 442 LK S + + + VA + + +Y S + Sbjct: 123 TLKFWDTRSS--NPMMVLQLPERCYCADVIYPMA---VVATAERGLIVYQLENQPSEFRR 177 Query: 443 TEVPISYNSSCVALSNDKQF----VAVGGQDSKVHV--------------YKLSGASVSE 484 E P+ + CVA+ DKQ A+G + +V + +K ++ + Sbjct: 178 IESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTN 237 Query: 485 VKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSW 544 + +AF L + + +L + ++ + Sbjct: 238 TSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLD---QPISACCF 294 Query: 545 SPDNVRLATGSL 556 + + A S Sbjct: 295 NHNGNIFAYASS 306 Score = 80.3 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 26/121 (21%), Positives = 54/121 (44%), Gaps = 5/121 (4%) Query: 491 PAEITSVAFSNN---GAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPD 547 I ++FS G FL+A + V + V ++ + + HT V V WS D Sbjct: 10 DDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTI-PKAQQMHTGPVLDVCWSDD 68 Query: 548 NVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFW 607 ++ T S D + +W+++ I + + +++ + N + +++ D +KFW Sbjct: 69 GSKVFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFW 127 Query: 608 N 608 + Sbjct: 128 D 128 Score = 73.8 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 21/130 (16%), Positives = 53/130 (40%), Gaps = 10/130 (7%) Query: 453 CVALSND---KQFVAVGGQDSKVHVYKLSGASVSEVKTI-VHPAEITSVAFSNNGAFLVA 508 C++ S F+ G + V +++ + + K +H + V +S++G+ + Sbjct: 15 CLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFT 74 Query: 509 TDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSW--SPDNVRLATGSLDNSVIVWNMN 566 + + +++N + H A V + W +P+ + TGS D ++ W+ Sbjct: 75 ASCDKTAKMWDLSSNQAIQ----IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTR 130 Query: 567 KPSDHPIIIK 576 + ++ Sbjct: 131 SSNPMMVLQL 140 Score = 72.2 bits (175), Expect = 6e-13, Method: Composition-based stats. Identities = 43/289 (14%), Positives = 73/289 (25%), Gaps = 70/289 (24%) Query: 34 QYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTH 93 + N + V T + H+ S G + ++WD + Sbjct: 32 SWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQA 91 Query: 94 ILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDT----------------- 136 I I PVK I W + ++ + + Sbjct: 92 IQ---IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCAD 148 Query: 137 -------------GTSNGNLTGQARAM-----------NSVDF---KPSRPFRIISGSDD 169 G L Q V K ++P GS + Sbjct: 149 VIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIE 208 Query: 170 NTVAIFEGPPFKFKS---TFGEHTK------------FVHSVRYNPDGSLFASTGGDGTI 214 VAI P TF H V+ + ++P A+ G DG Sbjct: 209 GRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRF 268 Query: 215 VLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIA-SASADKT 262 ++ TK E + ++ +G A ++S D + Sbjct: 269 SFWDKDARTKLKTSEQLDQ-------PISACCFNHNGNIFAYASSYDWS 310 Score = 70.7 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 39/316 (12%), Positives = 94/316 (29%), Gaps = 35/316 (11%) Query: 239 SGSVFGLTWSPD---GTKIASASADKTIKIWNVATLKVEKTIPVGTR-IEDQQLGIIWT- 293 S+ L++SP G + + S ++ W V +TIP + L + W+ Sbjct: 10 DDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDS--GQTIPKAQQMHTGPVLDVCWSD 67 Query: 294 -KQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSS--SADGKTLFSADAEGHINS 350 + + S + + Q+ H+ + + + + + + + + Sbjct: 68 DGSKVFTASCDKTAKMWDLSSNQAIQIAQ-HDAPVKTIHWIKAPNYSCVMTGSWDKTLKF 126 Query: 351 WDISTGISNRVFPDVHATMITGIKTT------SKGDLFTVSWDDHLKVVPAGGSGVD--- 401 WD + V + ++ L ++ S + Sbjct: 127 WDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQH 186 Query: 402 -SSKAVANKLSSQPLGLAVSADGDIAVAACY-----KHIAIYSHGKLTEVPIS-----YN 450 +K + S +G +A+ K + + S Y Sbjct: 187 RCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYA 246 Query: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGA---FLV 507 + +A +A G D + + + + + I++ F++NG + Sbjct: 247 VNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQL-DQPISACCFNHNGNIFAYAS 305 Query: 508 ATDQSRKVIPYSVANN 523 + D S+ Y+ Sbjct: 306 SYDWSKGHEFYNPQKK 321 Score = 47.9 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 15/76 (19%), Positives = 28/76 (36%), Gaps = 3/76 (3%) Query: 537 AKVACVSWSPD---NVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNET 593 + C+S+SP L GS N V W + + H ++ + + Sbjct: 11 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGS 70 Query: 594 TIVSAGQDSNIKFWNV 609 + +A D K W++ Sbjct: 71 KVFTASCDKTAKMWDL 86 >5CXB-B nrPDB Length = 369 Score = 88.8 bits (218), Expect = 6e-18, Method: Composition-based stats. Identities = 66/400 (16%), Positives = 114/400 (28%), Gaps = 64/400 (16%) Query: 183 KSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSV 242 ++ F H V SV +P G A+ G DGT+ ++ + G + + + +V Sbjct: 14 QTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNG------DEAV 67 Query: 243 FGLTWSPDGTKI---ASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVS 299 + W P A+A D + I T P T DQ + +++ Sbjct: 68 NTVRWRPTKDTFILAAAAGEDIFLMI---------PTHPSVTPALDQ------ASRDILN 112 Query: 300 ISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISN 359 N + G + G L + + I+ + Sbjct: 113 AGFGHATNGKQQANLPPGKEPPGK--------WARPGTRL----EDEGV-LLRITVRSTI 159 Query: 360 RVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAV 419 + H + G +V+ K + +A S PL Sbjct: 160 KAI-SWHRRGDHFATVSPSGQRSSVAIHTLSKHLTQ--IPFRKLNGLAQTASFHPLRPLF 216 Query: 420 SADGDIAVAACYKHIAIYSHGKLTEVPI----SYNSSCVALSNDKQFVAVGGQDSKVHVY 475 A + I Y KL V I + S + + VG D ++ ++ Sbjct: 217 -------FVATQRSIRCYDLQKLELVKIVQPGAKWISSFDVHPGGDNLVVGSYDKRL-LW 268 Query: 476 KLSGASVSEVKTIV-HPAEITSVAFSNNGAFLVA-TDQSRKVIPY------SVANNFELA 527 S KT+ H I +V F G L A + + N + Sbjct: 269 HDLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIV 328 Query: 528 HTNSWTFHTA----KVACVSWSPDNVRLATGSLDNSVIVW 563 H V + W P + D + +W Sbjct: 329 PVKMLKGHKVVNKLGVLDIDWHPREPWCVSAGADGTARLW 368 Score = 85.7 bits (210), Expect = 5e-17, Method: Composition-based stats. Identities = 44/358 (12%), Positives = 99/358 (27%), Gaps = 70/358 (19%) Query: 317 DQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTT 376 + GH + +++ G L + +G + W++ TG + ++ Sbjct: 14 QTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWR 73 Query: 377 SKGDLF---TVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSAD-------GDIA 426 D F + +D ++P S + + + + G A + G Sbjct: 74 PTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPGKEP 133 Query: 427 VAACYKH-IAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSK-------------- 471 + + G L + + ++ A + Sbjct: 134 PGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRSSVAIHTLSKHLT 193 Query: 472 ------------------------------VHVYKLSGASVSEVKTIVHPAEITSVAFSN 501 + Y L + ++ I+S Sbjct: 194 QIPFRKLNGLAQTASFHPLRPLFFVATQRSIRCYDLQKLELVKIVQPG-AKWISSFDVHP 252 Query: 502 NGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDN-VRLATGSLDNSV 560 G LV ++++ + + + T + HT + V + A S D S+ Sbjct: 253 GGDNLVVGSYDKRLLWHDLDLSNRPYKTMRF--HTEAIRAVRFHKGGLPLFADASDDGSL 310 Query: 561 IVW-------NMNKPSDHPIIIKGAHAM----SSVNSVIWLNETTIVSAGQDSNIKFW 607 ++ + P+ P+ + H + ++ E VSAG D + W Sbjct: 311 QIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWCVSAGADGTARLW 368 Score = 73.4 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 38/239 (15%), Positives = 77/239 (32%), Gaps = 31/239 (12%) Query: 88 TTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVG-EGRERFGHVFLFD---TGTSNGNL 143 +L+ T+ +K ISW A V G+ + T L Sbjct: 144 LEDEGVLLRITVRS---TIKAISWHRRGDHFATVSPSGQRSSVAIHTLSKHLTQIPFRKL 200 Query: 144 TGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGS 203 G A+ + F P RP ++ ++ ++ + K++ S +P G Sbjct: 201 NGLAQTAS---FHPLRPLFFVATQR--SIRCYDLQKLELVKIVQPGAKWISSFDVHPGGD 255 Query: 204 LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG-TKIASASADKT 262 D + L++ +D + H+ ++ + + G A AS D + Sbjct: 256 NLVVGSYDKRL-LWHDLDLSNRPYKTMRF-----HTEAIRAVRFHKGGLPLFADASDDGS 309 Query: 263 IKIW--NVATLKVEKT----------IPVGTRIEDQQLGIIWTKQALVSISANGFINFV 309 ++I+ V ++E V ++ + + VS A+G Sbjct: 310 LQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWCVSAGADGTARLW 368 Score = 73.4 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 48/373 (12%), Positives = 92/373 (24%), Gaps = 93/373 (24%) Query: 53 EIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISW- 111 I+ H + P+G A+G G VR+W+ + + V + W Sbjct: 15 TIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEA-VNTVRWR 73 Query: 112 ------------------------------DSESKRIAAVGEGRERFGH----------- 130 D S+ I G G G Sbjct: 74 PTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPGKEP 133 Query: 131 --------VFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKF 182 L D G + ++ + R + S Sbjct: 134 PGKWARPGTRLEDEGVLLRITV--RSTIKAISWH-RRGDHFATVSPSG------QRSSVA 184 Query: 183 KSTFGEH---------TKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSL 233 T +H + ++P LF +I Y+ + + + Sbjct: 185 IHTLSKHLTQIPFRKLNGLAQTASFHPLRPLFFVATQ-RSIRCYDLQKLELVKIVQPGA- 242 Query: 234 KNVAHSGSVFGLTWSPDGTKIASASADKTIKIW-NVA-TLKVEKTIPVGTRIEDQQLGII 291 + P G + S DK + +W ++ + + KT+ T Sbjct: 243 ------KWISSFDVHPGGDNLVVGSYDKRL-LWHDLDLSNRPYKTMRFHTEAIRAVRFHK 295 Query: 292 WTKQALVSISANGFINFVNPELGS---------IDQVRYGHNK----AITALSSSADGKT 338 S +G + + ++ + ++ GH + + Sbjct: 296 GGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPW 355 Query: 339 LFSADAEGHINSW 351 SA A+G W Sbjct: 356 CVSAGADGTARLW 368 Score = 69.9 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 46/386 (11%), Positives = 104/386 (26%), Gaps = 77/386 (19%) Query: 138 TSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKF-VHSV 196 G + SV P+ + +G DD TV ++E + + + V++V Sbjct: 12 VQQTIFRGHEGRVRSVAIDPT-GVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTV 70 Query: 197 RYNPDGSLF---ASTGGDGTIVL----------------------YNGVDGTKTGVF--- 228 R+ P F A+ G D +++ + +G + Sbjct: 71 RWRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPG 130 Query: 229 ---------------EDDSLKNVAHSGSVFGLTWSPDGTKIASASADK---TIKIWNVAT 270 ++ L + ++ ++W G A+ S ++ I ++ Sbjct: 131 KEPPGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRSSVAIHTLSK 190 Query: 271 LKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITAL 330 + + Q + + I + + + ++ K I++ Sbjct: 191 HLTQIPFRKLNGLA-QTASFHPLRPLFFVAT-QRSIRCYDLQKLELVKIVQPGAKWISSF 248 Query: 331 SSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKG-DLFTVSWDDH 389 G L + + D+ H I ++ G LF + DD Sbjct: 249 DVHPGGDNLVVGSYDKRLLWHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDG 308 Query: 390 LKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISY 449 + G K ++L + + G V Sbjct: 309 SLQIFHG-------KVPNDQLENPTIVPVKMLKGHKVVNKL------------------- 342 Query: 450 NSSCVALSNDKQFVAVGGQDSKVHVY 475 + + + G D ++ Sbjct: 343 GVLDIDWHPREPWCVSAGADGTARLW 368 Score = 60.7 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 48/377 (12%), Positives = 112/377 (29%), Gaps = 67/377 (17%) Query: 87 DTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLT-G 145 + + +T G V+ ++ D +A G+ V+ TG ++ Sbjct: 5 ELKPFPTVQQTIFRGHEGRVRSVAIDPTGVALATGGDDG--TVRVWELLTGRQVWSVKLN 62 Query: 146 QARAMNSVDFKPSRPFRI--ISGSDDNTVAI---------FEGPPFKFKSTFGEHT---- 190 A+N+V ++P++ I + +D + I + + H Sbjct: 63 GDEAVNTVRWRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGK 122 Query: 191 ----------------------------------KFVHSVRYNPDGSLFASTGGDGTIVL 216 + ++ ++ G FA+ G Sbjct: 123 QQANLPPGKEPPGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQ--- 179 Query: 217 YNGVDGTKTGVFEDDSLKNVAHSGSVFG--LTWSPDGTKIASASADKTIKIWNVATLKVE 274 + + ++ P A+ ++I+ +++ L++ Sbjct: 180 ---RSSVAIHTLSKHLTQIPFRKLNGLAQTASFHPLRPLFFVATQ-RSIRCYDLQKLELV 235 Query: 275 KTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPE-LGSIDQVRYGHNKAITALSSS 333 K + G + + LV S + + + + + + H +AI A+ Sbjct: 236 KIVQPGAK-WISSFDVHPGGDNLVVGSYDKRLLWHDLDLSNRPYKTMRFHTEAIRAVRFH 294 Query: 334 ADGKTLFS-ADAEGHINSWDIS-TGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLK 391 G LF+ A +G + + V M+ G K +K + + W H + Sbjct: 295 KGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDW--HPR 352 Query: 392 VVPAGGSGVDSSKAVAN 408 +G D + + Sbjct: 353 EPWCVSAGADGTARLWM 369 Score = 51.4 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 22/83 (26%), Positives = 36/83 (43%), Gaps = 4/83 (4%) Query: 524 FELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSS 583 F + H +V V+ P V LATG D +V VW + + + + + Sbjct: 9 FPTVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWEL--LTGRQVWSVKLNGDEA 66 Query: 584 VNSVIW--LNETTIVSAGQDSNI 604 VN+V W +T I++A +I Sbjct: 67 VNTVRWRPTKDTFILAAAAGEDI 89 Score = 46.0 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 14/85 (16%), Positives = 24/85 (28%), Gaps = 5/85 (5%) Query: 481 SVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVA 540 +V + H + SVA G L V + + ++ V Sbjct: 11 TVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDE--AVN 68 Query: 541 CVSWSPDNVRL---ATGSLDNSVIV 562 V W P A D +++ Sbjct: 69 TVRWRPTKDTFILAAAAGEDIFLMI 93 Score = 29.1 bits (63), Expect = 5.4, Method: Composition-based stats. Identities = 6/36 (16%), Positives = 12/36 (33%) Query: 574 IIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 I H + I + + G D ++ W + Sbjct: 15 TIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWEL 50 >6F1U-h nrPDB Length = 612 Score = 86.5 bits (212), Expect = 3e-17, Method: Composition-based stats. Identities = 37/230 (16%), Positives = 73/230 (31%), Gaps = 21/230 (9%) Query: 56 TEHSHQTTVAKT--SPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGP----VKDI 109 H+H + + + S G + W +H + V V + Sbjct: 352 AAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSM 411 Query: 110 SW--DSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKP-----SRPFR 162 S+ + + EG G S G + + Sbjct: 412 SFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEM-FEGHQGPITGIHCHAAVGAVDFSHL 470 Query: 163 IISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGD--GTIVLYNGV 220 ++ S D TV ++ K +F ++ +V+ V ++P D G + L+N Sbjct: 471 FVTSSFDWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALF-ACVDGMGRLDLWNLN 529 Query: 221 DGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT 270 + T+ N A + + W+ G +IA ++ I I++V Sbjct: 530 NDTEVPTASISVEGNPA----LNRVRWTHSGREIAVGDSEGQIVIYDVGE 575 Score = 79.1 bits (193), Expect = 5e-15, Method: Composition-based stats. Identities = 47/346 (13%), Positives = 101/346 (29%), Gaps = 46/346 (13%) Query: 242 VFGLTWSPDGTKIASASA----------DKTIKIWNVATLKVEKTIPVGTRIEDQQLGII 291 V L WS ++ AS D +WN+ K + Sbjct: 256 VSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFA 315 Query: 292 -WTKQALVSISANGFINFVNPELGSIDQVR------YGHNKAITALSS--SADGKTLFSA 342 + +V + +G I + V+ H + ++ + + L S Sbjct: 316 KFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISI 375 Query: 343 DAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDS 402 +G I SW + + ++ + TS F V ++ V GS + Sbjct: 376 STDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMS--FPVGDVNNFVVGSEEGSVYTA 433 Query: 403 SKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQF 462 + G++ +G G +T + V S Sbjct: 434 CRHG------SKAGISEMFEGH--------------QGPITGIHCHAAVGAVDFS---HL 470 Query: 463 VAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVAT-DQSRKVIPYSVA 521 D V ++ + V +S L A D ++ +++ Sbjct: 471 FVTSSFDWTVKLWSTKNNKPLYSFEDN-AGYVYDVMWSPTHPALFACVDGMGRLDLWNLN 529 Query: 522 NNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNK 567 N+ E+ + + V W+ +A G + ++++++ + Sbjct: 530 NDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGE 575 Score = 72.2 bits (175), Expect = 6e-13, Method: Composition-based stats. Identities = 43/332 (12%), Positives = 88/332 (26%), Gaps = 54/332 (16%) Query: 62 TTVAKTSPSGYYCASGDV----------HGNVRIWDTTQTTHILKTTIPVFSGPVKDISW 111 + S G +W+ + V ++ Sbjct: 256 VSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVF-HCQSAVMSATF 314 Query: 112 DSESKRIAAVGEGRERFGHVFLFDTGTSNGN--------LTGQARAMNSVDFK-PSRPFR 162 + G G + L+D ++ + V+ Sbjct: 315 AKFHPNLVVGG---TYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHN 371 Query: 163 IISGSDDNTVAIFEGPPFKFKSTFGE--HTK----FVHSVRYNPDGS--LFASTGGDGTI 214 +IS S D + + E H + V S+ + P G F +G++ Sbjct: 372 LISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSF-PVGDVNNFVVGSEEGSV 430 Query: 215 VLYNGVDGTKTGVFEDDSLKNVAHSGSVF---------GLTWSPDGTKIASASADKTIKI 265 + G S H G + + +S ++S D T+K+ Sbjct: 431 Y-----TACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFS---HLFVTSSFDWTVKL 482 Query: 266 WNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRY---- 321 W+ K + + + G ++ N + Sbjct: 483 WSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVE 542 Query: 322 GHNKAITALSSSADGKTLFSADAEGHINSWDI 353 G N A+ + + G+ + D+EG I +D+ Sbjct: 543 G-NPALNRVRWTHSGREIAVGDSEGQIVIYDV 573 Score = 68.0 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 53/330 (16%), Positives = 106/330 (32%), Gaps = 51/330 (15%) Query: 323 HNKAITALSSSADGKTLFSADA----------EGHINSWDISTGISNRVFPDVHATMITG 372 ++ ++ L S+ L A +G W++ + + + + Sbjct: 252 KHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMS 311 Query: 373 IKTTSKGDLFTVS---------WDDH------LKVVPAGGSGVDSSKAVANKLSSQPL-- 415 V WD+ ++ P + N + +Q Sbjct: 312 ATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHN 371 Query: 416 GLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSN------DKQFVAVGGQD 469 +++S DG I C + + SH + + + S VA+++ D VG ++ Sbjct: 372 LISISTDGKI----CSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEE 427 Query: 470 SKVHV-YKLSGASVSEVKTIVHPAEITSVAFSNN------GAFLVATDQSRKVIPYSVAN 522 V+ + + H IT + V + V +S N Sbjct: 428 GSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKN 487 Query: 523 NFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIV--WNMNKPSDHPIIIKGAHA 580 N L S+ + V V WSP + L +D + WN+N ++ P Sbjct: 488 NKPL---YSFEDNAGYVYDVMWSPTHPALFA-CVDGMGRLDLWNLNNDTEVPTASISVEG 543 Query: 581 MSSVNSVIWLNETTIVSAGQ-DSNIKFWNV 609 ++N V W + ++ G + I ++V Sbjct: 544 NPALNRVRWTHSGREIAVGDSEGQIVIYDV 573 Score = 29.1 bits (63), Expect = 6.1, Method: Composition-based stats. Identities = 11/76 (14%), Positives = 26/76 (34%), Gaps = 5/76 (6%) Query: 26 NTPAGDKIQYC----NGTSVYTVPVGSLTDTEIYTEHSHQTTV-AKTSPSGYYCASGDVH 80 +P + C ++ + + T + + + + SG A GD Sbjct: 506 WSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSE 565 Query: 81 GNVRIWDTTQTTHILK 96 G + I+D + + + Sbjct: 566 GQIVIYDVGEQIAVPR 581 >2P9P-C nrPDB Length = 372 Score = 86.1 bits (211), Expect = 4e-17, Method: Composition-based stats. Identities = 53/389 (13%), Positives = 113/389 (29%), Gaps = 51/389 (13%) Query: 105 PVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRII 164 P+ +W+ + +IA E + + L + VD+ P RI+ Sbjct: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSN-RIV 68 Query: 165 SGSDDNTVAIF--EGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDG 222 + D ++ +G +K + VR+ P+ FA G I + Sbjct: 69 TCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQE 128 Query: 223 TKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTR 282 V + +V L W P+ +A+ S D +I++ +VE+ Sbjct: 129 NDWWVCKHIKKPI---RSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEER-----P 180 Query: 283 IEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSA 342 + + + S++ + + SA+G + Sbjct: 181 APTPWGSKMPFGELMFESSSS--------------------CGWVHGVCFSANGSRVAWV 220 Query: 343 DAEGHINSWDISTGISNRVFPDVHATMI------TGIKTTSKGDLFTVSWDDHLKVVPAG 396 + + D ++ ++ + D F V + Sbjct: 221 SHDSTVCLADADKKMAVATLASETLPLLAVTFITESSLVAAGHDCFPVLFTYDSAAGKLS 280 Query: 397 GSG------VDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYN 450 G S + + + Q L S++G A A + S +++ V Sbjct: 281 FGGRLDVPKQSSQRGLTARERFQNLDKKASSEGSAAAGAGLDSLHKNSVSQIS-VLSGGK 339 Query: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLSG 479 + C G D + ++ + Sbjct: 340 AKCSQF-------CTTGMDGGMSIWDVRS 361 Score = 75.3 bits (183), Expect = 7e-14, Method: Composition-based stats. Identities = 40/231 (17%), Positives = 82/231 (35%), Gaps = 14/231 (6%) Query: 61 QTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAA 120 + + A + V I++ + + + +G V + W +S RI Sbjct: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVT 69 Query: 121 VGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPS-RPFRIISGSDDNTVAIFEGPP 179 G R + T + RA V + P+ + F + SGS ++ FE Sbjct: 70 CGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQEN 129 Query: 180 --FKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNG-----------VDGTKTG 226 + K V S+ ++P+ L A+ D +++ Sbjct: 130 DWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKM 189 Query: 227 VFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTI 277 F + ++ + G V G+ +S +G+++A S D T+ + + T+ Sbjct: 190 PFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAVATL 240 Score = 66.8 bits (161), Expect = 3e-11, Method: Composition-based stats. Identities = 51/366 (13%), Positives = 102/366 (27%), Gaps = 48/366 (13%) Query: 25 GNTPAGDKIQYCNGTSV---YTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHG 81 +I C Y EH+ Q T +P + Sbjct: 15 AWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVTCGTDR 74 Query: 82 NVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLF--DTGTS 139 N +W T I + + + W K+ A R F D Sbjct: 75 NAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQENDWWVC 134 Query: 140 NGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEG------------------PPFK 181 + S+D+ P+ + +GS D IF P + Sbjct: 135 KHIKKPIRSTVLSLDWHPNS-VLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGE 193 Query: 182 FKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGS 241 +VH V ++ +GS A D T+ L + ++L Sbjct: 194 LMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAVATLASETL-------P 246 Query: 242 VFGLTWSPDGTKIASASAD--KTIKIWNVATLKV---EKTIPVGTRIEDQQLGIIWTKQA 296 + +T+ + + +A D + ++ A K+ + + + Sbjct: 247 LLAVTFI-TESSLVAAGHDCFPVLFTYDSAAGKLSFGGRLDVPKQSSQRGLTARERFQNL 305 Query: 297 LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADG----KTLFSADAEGHINSWD 352 S+ G + + H +++ +S + G + +G ++ WD Sbjct: 306 DKKASSEGSA-------AAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWD 358 Query: 353 ISTGIS 358 + + S Sbjct: 359 VRSLES 364 Score = 64.1 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 30/152 (19%), Positives = 63/152 (41%), Gaps = 3/152 (1%) Query: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTI-VHPAEITSVAFSNNGAFLVAT 509 SC A + D+ +A+ + +VH+Y+ SG +V + H ++T V ++ + +V Sbjct: 11 ISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVTC 70 Query: 510 DQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIV-WNMNKP 568 R +++ + A CV W+P+ + A GS + + + + Sbjct: 71 GTDRNAYVWTLKGRTWKPTLVILRINRAA-RCVRWAPNEKKFAVGSGSRVISICYFEQEN 129 Query: 569 SDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQ 600 S+V S+ W + +++AG Sbjct: 130 DWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGS 161 Score = 63.4 bits (152), Expect = 3e-10, Method: Composition-based stats. Identities = 50/386 (12%), Positives = 115/386 (29%), Gaps = 44/386 (11%) Query: 192 FVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG 251 + +N D + A + + +Y V E H+G V G+ W+PD Sbjct: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELK-----EHNGQVTGVDWAPDS 64 Query: 252 TKIASASADKTIKIWNVATLKVEKTIPVGT-RIEDQQLGIIWTKQALVSISANGFINFVN 310 +I + D+ +W + + T+ + + + ++ S + I+ Sbjct: 65 NRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICY 124 Query: 311 PELGS----IDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVH 366 E + ++ + +L + L + + + +V Sbjct: 125 FEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFS-------AYIKEVE 177 Query: 367 ATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIA 426 T G + + S + S+ VS D + Sbjct: 178 ERP----APTPWGSKMPFG----ELMFESSSSCGWVHGVCFSANGSR--VAWVSHDSTVC 227 Query: 427 VAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVH-VYKLSGASVSEV 485 +A K +A+ + + V + VA G V Y + +S Sbjct: 228 LADADKKMAVATLA-----SETLPLLAVTFITESSLVAAGHDCFPVLFTYDSAAGKLSFG 282 Query: 486 KTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWS 545 + P + ++ L A ++ + + + + A + H V+ +S Sbjct: 283 GRLDVPKQ-------SSQRGLTARERFQNLDKKASSEGSAAAGAGLDSLHKNSVSQISVL 335 Query: 546 PDN----VRLATGSLDNSVIVWNMNK 567 + T +D + +W++ Sbjct: 336 SGGKAKCSQFCTTGMDGGMSIWDVRS 361 Score = 56.0 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 19/110 (17%), Positives = 42/110 (38%), Gaps = 3/110 (2%) Query: 493 EITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLA 552 I+ A++ + + + +V Y + + + H +V V W+PD+ R+ Sbjct: 10 PISCHAWNKDRTQIAICPNNHEVHIYE-KSGNKWVQVHELKEHNGQVTGVDWAPDSNRIV 68 Query: 553 TGSLDNSVIVWNMNKPS--DHPIIIKGAHAMSSVNSVIWLNETTIVSAGQ 600 T D + VW + + +I++ A V + + S + Sbjct: 69 TCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSR 118 Score = 53.0 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 34/257 (13%), Positives = 76/257 (29%), Gaps = 30/257 (11%) Query: 325 KAITALSSSADGKTLFSADAEGHINSWDISTGISNRV-FPDVHATMITGIKTTSKGD-LF 382 + I+ + + D + ++ ++ S +V H +TG+ + + Sbjct: 9 EPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIV 68 Query: 383 TVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAI------ 436 T D + V G + + + + AV + + I+I Sbjct: 69 TCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQE 128 Query: 437 --YSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASV------------ 482 + K + PI + + +A G D K ++ V Sbjct: 129 NDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSK 188 Query: 483 -----SEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTA 537 ++ + V FS NG+ + V +A + T Sbjct: 189 MPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAVA---TLASETL 245 Query: 538 KVACVSWSPDNVRLATG 554 + V++ ++ +A G Sbjct: 246 PLLAVTFITESSLVAAG 262 Score = 36.8 bits (83), Expect = 0.032, Method: Composition-based stats. Identities = 13/78 (16%), Positives = 29/78 (37%) Query: 532 WTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLN 591 +F ++C +W+ D ++A ++ V ++ + + H + Sbjct: 4 HSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPD 63 Query: 592 ETTIVSAGQDSNIKFWNV 609 IV+ G D N W + Sbjct: 64 SNRIVTCGTDRNAYVWTL 81 >3JZG-A nrPDB Length = 402 Score = 85.3 bits (209), Expect = 7e-17, Method: Composition-based stats. Identities = 47/288 (16%), Positives = 86/288 (29%), Gaps = 47/288 (16%) Query: 110 SWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDD 169 ++DS + G + T + G A+N + F P P ++S S D Sbjct: 114 TYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKD 173 Query: 170 NTVAIFEGPPFKFKSTF---GEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTG 226 + + ++ + F H V S Y+ G S G D ++ L+ Sbjct: 174 HALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMN 233 Query: 227 VFED---------------------DSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKI 265 ++ D H V + W G I S S + I Sbjct: 234 AIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW--LGDLILSKSCENAIVC 291 Query: 266 W-------NVATLK--------VEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFV- 309 W ++ +K + + I + + + ++ L + G + Sbjct: 292 WKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWD 351 Query: 310 ----NPELGSIDQVRYGHNK-AITALSSSADGKTLFSADAEGHINSWD 352 +P + + AI S S D L + + I WD Sbjct: 352 LEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 399 Score = 72.6 bits (176), Expect = 5e-13, Method: Composition-based stats. Identities = 51/376 (13%), Positives = 106/376 (28%), Gaps = 50/376 (13%) Query: 224 KTGVFEDDSLKNVAHSGSVFGLTWSPDGT-----KIASASADKTIKIWNVATLKVEKTIP 278 F+ + H+ +FG+ ++ A+ + + ++ + + + Sbjct: 39 CKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGS-NRVTLYECHSQGEIRLLQ 97 Query: 279 --VGTRIEDQQLGIIW------TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITAL 330 V ++ W + L + G I +NP + GH AI L Sbjct: 98 SYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINEL 157 Query: 331 SSSA-DGKTLFSADAEGHINSWDISTGISNRVFPDV--HATMITGIKTTSKGD-LFTVSW 386 D L S + + W+I T +F V H + G+ + + Sbjct: 158 KFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGM 217 Query: 387 DDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVP 446 D LK+ + ++ + + + + I Sbjct: 218 DHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIH----------- 266 Query: 447 ISYNSSCVALSNDKQFVAVGGQDSKVHVY---------KLSGASVSEVKTIVHPAE---- 493 CV + ++ + + S S V + Sbjct: 267 -RNYVDCVRWL--GDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCD 323 Query: 494 ITSVAFSNN--GAFLVATDQSRKVIPYSVANNFELAHTNSWTFHT---AKVACVSWSPDN 548 I + FS + L +Q K+ + + + H A + S+S D+ Sbjct: 324 IWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDS 383 Query: 549 VRLATGSLDNSVIVWN 564 L D S+ W+ Sbjct: 384 SILIAVCDDASIWRWD 399 Score = 70.7 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 30/292 (10%), Positives = 83/292 (28%), Gaps = 49/292 (16%) Query: 21 AVVLGNTPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAKTSP-SGYYCASGD 78 A + + + + + ++ + Y H + K P S Sbjct: 112 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS 171 Query: 79 VHGNVRIWDTTQTTHILK-TTIPVFSGPVKDISWDSESKRIAAVGEGRE-RFGHV----- 131 +R+W+ T + + V +D ++I + G + + Sbjct: 172 KDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRM 231 Query: 132 -------FLFDTGTSNGNLTG-------------QARAMNSVDFKPSRPFRIISGSDDNT 171 + ++ +N ++ V + I+S S +N Sbjct: 232 MNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW---LGDLILSKSCENA 288 Query: 172 VAIFE--------------GPPFKFKSTFGEHTKFVHSVRYNPD--GSLFASTGGDGTIV 215 + ++ F + +R++ D + A G + Sbjct: 289 IVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLY 348 Query: 216 LYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 +++ + +L + ++ ++S D + + + D +I W+ Sbjct: 349 VWDLEV-EDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 399 Score = 66.4 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 33/232 (14%), Positives = 73/232 (31%), Gaps = 32/232 (13%) Query: 407 ANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQ----F 462 + PL A + + C+ I + N A + D Sbjct: 64 WHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPL 123 Query: 463 VAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSN-NGAFLVATDQSRKVIPYSVA 521 +AV G + + + H I + F + L++ + + +++ Sbjct: 124 LAVAGSRGIIRIINPITMQCIKHYV-GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 182 Query: 522 NNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNK-------------- 567 + +A H +V + ++ + +D+S+ +W +N Sbjct: 183 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN 242 Query: 568 --PSDHPIIIKGAH---------AMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 ++ P I + H + V+ V WL + I+S ++ I W Sbjct: 243 PNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGD-LILSKSCENAIVCWK 293 Score = 49.5 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 25/112 (22%), Positives = 47/112 (41%), Gaps = 4/112 (3%) Query: 500 SNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDN 558 SN L+A SR +I + N + + H + + + P D L + S D+ Sbjct: 117 SNTSHPLLAVAGSRGII--RIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDH 174 Query: 559 SVIVWNMNKPSDHPIIIK-GAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 ++ +WN+ + I H +++ L I+S G D ++K W + Sbjct: 175 ALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI 226 >4E5Z-B nrPDB Length = 436 Score = 84.9 bits (208), Expect = 8e-17, Method: Composition-based stats. Identities = 45/305 (14%), Positives = 90/305 (29%), Gaps = 27/305 (8%) Query: 18 RGTAVVLGNTPA--GDKIQYCNGTSVYTVPVGSLTDTEIYTE--HSHQTTVAKTSP-SGY 72 A L P G + G T K +P + Sbjct: 119 DRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTN 178 Query: 73 YCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVF 132 + + G R+ D + + + + + S+ + + G+V Sbjct: 179 QFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTG----DNVGNVI 234 Query: 133 LFD-TGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGE--- 188 L + G NL + + V P + + + S D TV I++ + K++F Sbjct: 235 LLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP 294 Query: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 H V++ ++PDG+ +T I +Y+ ++ H + W Sbjct: 295 HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA-AWH 353 Query: 249 PDGTKI------------ASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLG-IIWTKQ 295 P I + +TI +++ + K+ + L Sbjct: 354 PRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGD 413 Query: 296 ALVSI 300 L S Sbjct: 414 TLASA 418 Score = 70.7 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 34/235 (14%), Positives = 70/235 (29%), Gaps = 14/235 (5%) Query: 131 VFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEG---PPFKFKSTFG 187 + D+ R S+ + P+ P + GS + ++ F G Sbjct: 103 LHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIG 162 Query: 188 EHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLT 246 + +++NP + + F ++ +GT L + G VF N+ L Sbjct: 163 A-GGSITGLKFNPLNTNQFYASSMEGTTRLQDFK-GNILRVFASSDTINI----WFCSLD 216 Query: 247 WSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFI 306 S + + + + N+ K + + + L + S + + Sbjct: 217 VSASSRMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTV 275 Query: 307 NFVNPELGSIDQVRYG---HNKAITALSSSADGKTLFSADAEGHINSWDISTGIS 358 + H + A S DG L + D + I + S Sbjct: 276 KIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDC 330 Score = 65.7 bits (158), Expect = 6e-11, Method: Composition-based stats. Identities = 41/238 (17%), Positives = 84/238 (35%), Gaps = 14/238 (5%) Query: 376 TSKGDLFTVSW--DDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKH 433 + GD+ ++ D + G+G + N L++ A S +G + + Sbjct: 139 SKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQ-FYASSMEGTTRLQDFKGN 197 Query: 434 IAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAE 493 I + + I + S + +S + V G V + + G + ++ +H + Sbjct: 198 I-LRVFASSDTINIWFCS--LDVSASSRMVVTGDNVGNVILLNMDGKELWNLR--MHKKK 252 Query: 494 ITSVAFSNNGAF-LVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLA 552 +T VA + + L + V + + A H V +SPD RL Sbjct: 253 VTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLL 312 Query: 553 TGSLDNSVIVWNMNKPSDHPIIIKGAH----AMSSVNSVIWLNETTIVSAGQ-DSNIK 605 T + + V++ ++ +I H ++ + + IV D N K Sbjct: 313 TTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFK 370 Score = 50.6 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 32/205 (15%), Positives = 70/205 (34%), Gaps = 21/205 (10%) Query: 423 GDIAVAACYKHIAIYSHGK------LTEVPISYNSSCVALSN-DKQFVAVGGQDSKVHVY 475 +AV + I +++ G + + + + + + + + + Sbjct: 133 STVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQ 192 Query: 476 KLSGASVSEVKTIVHPAEIT--SVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWT 533 G + V I S+ S + +V D VI ++ + Sbjct: 193 DFKGN-ILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGK----ELWNLR 247 Query: 534 FHTAKVACVSWSPDNVR-LATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW-LN 591 H KV V+ +P LAT S+D +V +W++ + + VN+ + + Sbjct: 248 MHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPD 307 Query: 592 ETTIVSAGQDSNIKF-----WNVPF 611 +++ Q S I+ W+ P Sbjct: 308 GARLLTTDQKSEIRVYSASQWDCPL 332 >4G56-B nrPDB Length = 357 Score = 84.2 bits (206), Expect = 2e-16, Method: Composition-based stats. Identities = 43/239 (17%), Positives = 83/239 (34%), Gaps = 20/239 (8%) Query: 62 TTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIP--VFSGPVKDISWDSESKRIA 119 T G V +W+ + +L VK +S S+ + Sbjct: 97 VTDVAWVSEK-GILVASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGTQ-- 153 Query: 120 AVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPP 179 AV G++ V+ + + +N V P + +S +D + +++ Sbjct: 154 AVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRK 213 Query: 180 FKFKS--TFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV 236 K + F SV ++P FA G + L N + D + + Sbjct: 214 PKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKN-------PDSAQTSA 266 Query: 237 AHSGSVFGLTWSPDGT-KIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK 294 HS ++ GL +S + +AS S D T+ + + +V + + D G+ W+ Sbjct: 267 VHSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRDLS----HRDFVTGVAWSP 321 Score = 76.8 bits (187), Expect = 3e-14, Method: Composition-based stats. Identities = 41/215 (19%), Positives = 74/215 (34%), Gaps = 21/215 (9%) Query: 56 TEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSES 115 EH G SG +V++WD +Q + + S V ++ Sbjct: 136 YEHDDIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQKAVL--KSYNAHSSEVNCVAACPGK 193 Query: 116 KRI-AAVGEGRERFGHVFLFDTGTSNG--NLTGQARAM--NSVDFKPSRPFRIISGSDDN 170 I + GE G + L+DT + A SV + P + G + Sbjct: 194 DTIFLSCGED----GRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETG 249 Query: 171 TVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGS-LFASTGGDGTIVLYNGVDGTKTGVFE 229 V++ T H++ + + Y+ S AS D T+ + + Sbjct: 250 NVSLVNIKNPDSAQTSAVHSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSE------ 303 Query: 230 DDSLKNVAHSGSVFGLTWSP-DGTKIASASADKTI 263 ++++H V G+ WSP D +K + D + Sbjct: 304 --VFRDLSHRDFVTGVAWSPLDHSKFTTVGWDHKV 336 Score = 65.3 bits (157), Expect = 8e-11, Method: Composition-based stats. Identities = 43/255 (16%), Positives = 88/255 (34%), Gaps = 12/255 (4%) Query: 190 TKFVHSVRY-NPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 V V + + G L AS G + L+ ++ V + H V L+ Sbjct: 94 EAGVTDVAWVSEKGILVASDS--GAVELWEILEKESLLV---NKFAKYEHDDIVKTLSVF 148 Query: 249 PDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINF 308 DGT+ S D ++K+W+++ V K+ + + +S +G I Sbjct: 149 SDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILL 208 Query: 309 VNPELGSID-QVRYGHNKAI-TALSSSAD-GKTLFSADAEGHINSWDISTGISNRVFPDV 365 + ++ + + I T+++ + T D G+++ +I S + V Sbjct: 209 WDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQT-SAV 267 Query: 366 HATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDI 425 H+ ITG+ + F S + V + + +++ G+A S Sbjct: 268 HSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRDLSH--RDFVTGVAWSPLDHS 325 Query: 426 AVAACYKHIAIYSHG 440 + H Sbjct: 326 KFTTVGWDHKVLHHH 340 Score = 64.1 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 58/371 (15%), Positives = 124/371 (33%), Gaps = 59/371 (15%) Query: 207 STGGD-GTIVLYNGVDGTKTGV-FEDDSLKNVAHSGSVFGLTWSPDGTKIASA------S 258 S+G D GT LY +G+ G + + + + DG + +A + Sbjct: 8 SSGVDLGTENLYFQSNGSSKGSAWGRPVTAPACMEVQIGAVRYRRDGALLLAASSLSSRT 67 Query: 259 ADKTIKIWNVATLKVEKTI-PVGTRIEDQQLGIIW-TKQALVSISANGFINFVNPELGSI 316 +I ++ +++ G + E + W +++ ++ S +G + Sbjct: 68 WGGSIWVFKDPEGAPNESLCTAGVQTEAGVTDVAWVSEKGILVASDSGAVELWEILEKES 127 Query: 317 DQV----RYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITG 372 V +Y H+ + LS +DG S + + WD+S + + H++ + Sbjct: 128 LLVNKFAKYEHDDIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQKAVLKS-YNAHSSEVNC 186 Query: 373 IKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYK 432 + D +S + +++ + + +P D Sbjct: 187 VAACPGKDTIFLSCGEDGRIL------------LWDTRKPKPATRIDFCASDTI------ 228 Query: 433 HIAIYSHGKLTEVPISYNSSCVALSNDK-QFVAVGGQDSKVHVYKLSGASVSEVKTIVHP 491 + V +K A G + V + + ++ + VH Sbjct: 229 ------------------PTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQT-SAVHS 269 Query: 492 AEITSVAFS-NNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP-DNV 549 IT +A+S ++ FL + + V + + H V V+WSP D+ Sbjct: 270 QNITGLAYSYHSSPFLASISEDCTVAVLDA----DFSEVFRDLSHRDFVTGVAWSPLDHS 325 Query: 550 RLATGSLDNSV 560 + T D+ V Sbjct: 326 KFTTVGWDHKV 336 Score = 57.6 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 27/119 (22%), Positives = 50/119 (42%), Gaps = 3/119 (2%) Query: 491 PAEITSVAFSNNGAFLVATDQSRKVIPYSV-ANNFELAHTNSWTFHTAKVACVSWSPDNV 549 A +T VA+ + LVA S V + + L + + H V +S D Sbjct: 94 EAGVTDVAWVSEKGILVA-SDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGT 152 Query: 550 RLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 + +G D SV VW++++ + + ++ V + +T +S G+D I W+ Sbjct: 153 QAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCV-AACPGKDTIFLSCGEDGRILLWD 210 Score = 52.2 bits (123), Expect = 6e-07, Method: Composition-based stats. Identities = 33/216 (15%), Positives = 72/216 (33%), Gaps = 18/216 (8%) Query: 401 DSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDK 460 D + S ++ D + V + + S+ S +CVA K Sbjct: 139 DDIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQKAVLKSYN-----AHSSEVNCVAACPGK 193 Query: 461 QFV-AVGGQDSKVHVYKLSGASVSEVKTIVHPAEI-TSVAFSNNG-AFLVATDQSRKVIP 517 + G+D ++ ++ + I TSV + D++ V Sbjct: 194 DTIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSL 253 Query: 518 YSVANNFELAHTNSWTFHTAKVACVSWS-PDNVRLATGSLDNSVIVWNMNKPSDHPIIIK 576 ++ N + H+ + +++S + LA+ S D +V V + + + + Sbjct: 254 VNIKNPDSAQTSAV---HSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSE----VFR 306 Query: 577 GAHAMSSVNSVIWL--NETTIVSAGQDSNIKFWNVP 610 V V W + + + G D + ++P Sbjct: 307 DLSHRDFVTGVAWSPLDHSKFTTVGWDHKVLHHHLP 342 Score = 42.6 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 20/174 (11%), Positives = 39/174 (22%), Gaps = 42/174 (24%) Query: 55 YTEHSHQTTVAKTSPSGYYC-ASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS 113 Y HS + P S G + +WDT + + ++W Sbjct: 177 YNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHP 236 Query: 114 ESKRIAAVGE--GRERFGHVFLFDTGTSNGNLTG-------------------------- 145 E A G+ G ++ D+ ++ + Sbjct: 237 EKDDTFACGDETGNVSLVNIKNPDSAQTSAVHSQNITGLAYSYHSSPFLASISEDCTVAV 296 Query: 146 -------------QARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTF 186 + V + P + + D+ V P Sbjct: 297 LDADFSEVFRDLSHRDFVTGVAWSPLDHSKFTTVGWDHKVLHHHLPSEGRTENL 350 Score = 36.0 bits (81), Expect = 0.046, Method: Composition-based stats. Identities = 18/104 (17%), Positives = 38/104 (36%), Gaps = 6/104 (5%) Query: 510 DQSRKVIPY-SVANNFELAHTNSWTFHTAKVACVSW-SPDNVRLATGSLDNSVIVWNM-- 565 + + + + A V V+W S + +A+ S +V +W + Sbjct: 67 TWGGSIWVFKDPEGAPNESLCTAGVQTEAGVTDVAWVSEKGILVASDS--GAVELWEILE 124 Query: 566 NKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 + K H ++ + T VS G+D ++K W++ Sbjct: 125 KESLLVNKFAKYEHDDIVKTLSVFSDGTQAVSGGKDFSVKVWDL 168 >5M89-A nrPDB Length = 329 Score = 82.6 bits (202), Expect = 5e-16, Method: Composition-based stats. Identities = 48/273 (17%), Positives = 88/273 (32%), Gaps = 15/273 (5%) Query: 255 ASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELG 314 A D + I++V KVE+T+ +G + + WT +V +A G++ + G Sbjct: 67 AVGGLDGKLDIYSVVANKVERTLDIGEPVTATE----WTGTKVVIGTAKGWVKVYDA--G 120 Query: 315 SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIK 374 H +T L+ G+ L S + +D+ TG RV +T Sbjct: 121 RESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGE--RVARGYADAALTTCA 178 Query: 375 TTSKGDLFTVSWDDHLKVVPAGGSGVDSSK----AVANKLSSQPLGLAVSADGDIAVAAC 430 G+LF +V + + L+ G +A G + Sbjct: 179 FHPDGNLFAAGTQTGHILVFHTTTLEQAESFPLGTPIQALAFSENGFWFAATGKGTSSVT 238 Query: 431 YKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDS-KVHVYKLSGASVSEVKTIV 489 + + + ++ Q++A GG V +Y + S SE + Sbjct: 239 IFDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATGGGTGVTVQMYTKATKSWSEPVRLG 298 Query: 490 HPAEITSVAFSNNGAFLVATDQSRKVIPYSVAN 522 + V + LV + V Sbjct: 299 --MPVVGVKWGGEAKRLVVVSREGVVSVLGKKE 329 Score = 81.5 bits (199), Expect = 1e-15, Method: Composition-based stats. Identities = 35/201 (17%), Positives = 78/201 (38%), Gaps = 17/201 (8%) Query: 149 AMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFAST 208 + + ++ +++ G+ V +++ + +TF H V + +P G + AS Sbjct: 94 PVTATEW---TGTKVVIGTAKGWVKVYDA--GRESATFQTHAGPVTGLAVHPGGRILASV 148 Query: 209 GGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNV 268 G D + V Y+ G + D+ ++ + PDG A+ + I +++ Sbjct: 149 GVDKSFVFYDLETGERVARGYADA--------ALTTCAFHPDGNLFAAGTQTGHILVFHT 200 Query: 269 ATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISA-NGFINFVNP-ELGSIDQVRYGHNKA 326 TL+ ++ P+GT I Q L + + + + G+ V+ Sbjct: 201 TTLEQAESFPLGTPI--QALAFSENGFWFAATGKGTSSVTIFDLRKSGAAAAVKELQTGE 258 Query: 327 ITALSSSADGKTLFSADAEGH 347 + ++S G+ L + G Sbjct: 259 VLSISWDYTGQYLATGGGTGV 279 Score = 74.5 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 46/260 (17%), Positives = 99/260 (38%), Gaps = 27/260 (10%) Query: 59 SHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRI 118 T + + G G G V+++D T +GPV ++ + + Sbjct: 92 GEPVTATEWT--GTKVVIGTAKGWVKVYDA----GRESATFQTHAGPVTGLAVHPGGRIL 145 Query: 119 AAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP 178 A+VG + + +TG A+ + F P +G+ + +F Sbjct: 146 ASVGVDKSFV--FYDLETGERVARGYA-DAALTTCAFHPDGNL-FAAGTQTGHILVFHTT 201 Query: 179 PFKFKSTFGEHTKFVHSVRYNPDGSLFASTGG-DGTIVLYNGV-DGTKTGVFEDDSLKNV 236 + +F T + ++ ++ +G FA+TG ++ +++ G V E Sbjct: 202 TLEQAESFPLGT-PIQALAFSENGFWFAATGKGTSSVTIFDLRKSGAAAAVKELQ----- 255 Query: 237 AHSGSVFGLTWSPDGTKIASASADK-TIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQ 295 +G V ++W G +A+ T++++ K K+ R+ +G+ W + Sbjct: 256 --TGEVLSISWDYTGQYLATGGGTGVTVQMY----TKATKSWSEPVRLGMPVVGVKWGGE 309 Query: 296 A--LVSISANGFINFVNPEL 313 A LV +S G ++ + + Sbjct: 310 AKRLVVVSREGVVSVLGKKE 329 Score = 71.1 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 36/240 (15%), Positives = 80/240 (33%), Gaps = 19/240 (7%) Query: 29 AGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDT 88 G K+ + + ++ + H+ T P G AS V + +D Sbjct: 101 TGTKVVI-GTAKGWVKVYDAGRESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDL 159 Query: 89 TQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQAR 148 + + + ++ + AA + GH+ +F T T + Sbjct: 160 ETGERVAR---GYADAALTTCAFHPDGNLFAAG----TQTGHILVFHTTTLEQAESFPLG 212 Query: 149 -AMNSVDFKPSRPFRIISGSDDNTVAIFEGP-PFKFKSTFGEHTKFVHSVRYNPDGSLFA 206 + ++ F + + +G ++V IF+ + T V S+ ++ G A Sbjct: 213 TPIQALAFSENGFWFAATGKGTSSVTIFDLRKSGAAAAVKELQTGEVLSISWDYTGQYLA 272 Query: 207 STGGDG-TIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKI 265 + GG G T+ +Y + + V G+ W + ++ S + + + Sbjct: 273 TGGGTGVTVQMYTKATKSWSEPVRLGM--------PVVGVKWGGEAKRLVVVSREGVVSV 324 Score = 54.5 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 26/148 (17%), Positives = 58/148 (39%), Gaps = 9/148 (6%) Query: 424 DIAVAACYKHIAIYSHGKLTEVPISYNS--SCVALSNDKQFVAVGGQDSKVHVYKLSGAS 481 + + + +Y G+ + ++ + +A+ + +A G D Y L Sbjct: 104 KVVIGTAKGWVKVYDAGRESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGE 163 Query: 482 VSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVAC 541 V A +T+ AF +G A Q+ ++ + + L S+ T + Sbjct: 164 --RVARGYADAALTTCAFHPDGNLFAAGTQTGHILVF---HTTTLEQAESFPLGT-PIQA 217 Query: 542 VSWSPDNVRL-ATGSLDNSVIVWNMNKP 568 +++S + ATG +SV ++++ K Sbjct: 218 LAFSENGFWFAATGKGTSSVTIFDLRKS 245 Score = 46.0 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 26/137 (18%), Positives = 51/137 (37%), Gaps = 13/137 (9%) Query: 464 AVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANN 523 AVGG D K+ +Y + V I P +T+ + G +V V Y Sbjct: 67 AVGGLDGKLDIYSVVANKVERTLDIGEP--VTATEW--TGTKVVIGTAKGWVKVYDAGRE 122 Query: 524 FELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSS 583 T H V ++ P LA+ +D S + +++ + +A ++ Sbjct: 123 SATFQT-----HAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGER----VARGYADAA 173 Query: 584 VNSVIWLNETTIVSAGQ 600 + + + + + +AG Sbjct: 174 LTTCAFHPDGNLFAAGT 190 >5MC6-j nrPDB Length = 397 Score = 82.2 bits (201), Expect = 5e-16, Method: Composition-based stats. Identities = 38/152 (25%), Positives = 61/152 (40%), Gaps = 17/152 (11%) Query: 147 ARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFG------EHTKFVHSVRYNP 200 ++ SVD I +G ++ TV I E + F ++ + SV+++P Sbjct: 186 SQFATSVDIS--ERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSP 243 Query: 201 DGSLFAST---GGDGTIVLYNGVDGTKTGVFEDD------SLKNVAHSGSVFGLTWSPDG 251 GSL A G I LY G + G SL AHS V L+++ G Sbjct: 244 QGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSG 303 Query: 252 TKIASASADKTIKIWNVATLKVEKTIPVGTRI 283 + SA D ++ W+V T + T+ + Sbjct: 304 ETLCSAGWDGKLRFWDVKTKERITTLNMHCDD 335 Score = 68.7 bits (166), Expect = 8e-12, Method: Composition-based stats. Identities = 47/360 (13%), Positives = 110/360 (30%), Gaps = 68/360 (18%) Query: 225 TGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIE 284 + VF + AH +F ++ + S S D +K+W+ L E Sbjct: 2 SKVFIATANAGKAHDADIFSVSAC--NSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHF 59 Query: 285 DQQLGI------------IWTKQALVSISA------------NGFINFVNPELGSIDQVR 320 + G+ + + + S + + +L +D Sbjct: 60 VHKSGLHHVDVLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDM 119 Query: 321 YGHNKAITALSSSAD---GKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTS 377 H+ +S D L + D +G W Sbjct: 120 KKHSFWALKWGASNDRLLSHRLVATDVKGTTYIWKFHP-------------------FAD 160 Query: 378 KGDLFTVSWDDHLKVVPAGGSGVDSSK-AVANKLSSQPLGLAVSADGDIAVAACYKHIAI 436 + + T++W L++ S + S+ A + +S + L +G + ++ + Sbjct: 161 ESNSLTLNWSPTLELQGTVESPMTPSQFATSVDISERGLIATGFNNGTVQISELSTLRPL 220 Query: 437 YSH-GKLTEVPISYNSSCVALSNDKQFVAVGGQDSK---VHVYKLSGA------------ 480 Y+ + + + S + V S +A+ + + +Y+ Sbjct: 221 YNFESQHSMINNSNSIRSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHS 280 Query: 481 SVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVA 540 S + + H + + S++F+++G L + K+ + V + H + Sbjct: 281 SQASLGEFAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTK---ERITTLNMHCDDIE 337 Score = 61.0 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 45/351 (12%), Positives = 95/351 (27%), Gaps = 76/351 (21%) Query: 56 TEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDT----TQTTHILKTTIPVFSGPVKDISW 111 +H + S + S G +++WD + + V + + Sbjct: 11 AGKAHDADIFSVSACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDV 70 Query: 112 -----------------DSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAM--NS 152 + + V + ++ + Sbjct: 71 LQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKWG 130 Query: 153 VDFKPSRPFRIISGSDDNTVAIFEGP-----------PFKFKSTFGE-------HTKFVH 194 R+++ T I++ + ++F Sbjct: 131 ASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFAT 190 Query: 195 SVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKI 254 SV + G L A+ +GT+ + FE + +S S+ + +SP G+ + Sbjct: 191 SVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQ-HSMINNSNSIRSVKFSPQGSLL 248 Query: 255 ASASADK---TIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNP 311 A A I ++ + ++ V T LG Sbjct: 249 AIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLG---------------------- 286 Query: 312 ELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVF 362 + H+ + +LS + G+TL SA +G + WD+ T Sbjct: 287 --------EFAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTL 329 Score = 59.9 bits (143), Expect = 4e-09, Method: Composition-based stats. Identities = 26/171 (15%), Positives = 56/171 (32%), Gaps = 26/171 (15%) Query: 59 SHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPV----FSGPVKDISWDSE 114 S T S G A+G +G V+I + + + S ++ + + + Sbjct: 186 SQFATSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQ 244 Query: 115 SKRIAAVGEGRERFGHVFLFDT--GTSNGNLT-------------GQARAMNSVDFKPSR 159 +A + FG + L++T G G+L+ + + S+ F Sbjct: 245 GSLLA-IAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFN-DS 302 Query: 160 PFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVH----SVRYNPDGSLFA 206 + S D + ++ + +T H + + + G A Sbjct: 303 GETLCSAGWDGKLRFWDVKTKERITTLNMHCDDIEIEEDILAVDEHGDSLA 353 Score = 41.8 bits (96), Expect = 8e-04, Method: Composition-based stats. Identities = 19/87 (21%), Positives = 30/87 (34%), Gaps = 8/87 (9%) Query: 21 AVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVH 80 + L T G++I +VP S + HS + SG S Sbjct: 259 CITLYETEFGERI------GSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCSAGWD 312 Query: 81 GNVRIWDTTQTTHILKTTIPVFSGPVK 107 G +R WD T TT+ + ++ Sbjct: 313 GKLRFWDV--KTKERITTLNMHCDDIE 337 >6CHG-D nrPDB Length = 439 Score = 81.1 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 56/369 (15%), Positives = 124/369 (33%), Gaps = 52/369 (14%) Query: 174 IFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSL 233 + + P K T V V+++P G A +G I++Y+ + S Sbjct: 12 VLKEYPEKLTHTLEVPVAAV-CVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSG 70 Query: 234 KNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT-LKVEKTIPVGTRIEDQQLGIIW 292 AH+ SV + WS DG + S+ D K+W++ K + + ++ Sbjct: 71 ---AHTRSVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQQYKFDGPLW--SCHVVR 125 Query: 293 TKQALVSIS----------ANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSA 342 +V++ + F L DQ GH + A + + Sbjct: 126 WNVCIVTVVEEPTAYVLTLTDRQNAFHCFPLLEQDQDISGHGYTLVACPHPTIESIIITG 185 Query: 343 DAEGHINSW--DISTGISNRV----FPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAG 396 ++G IN++ D+ +G +++ + I I + G ++ D Sbjct: 186 TSKGWINAFQLDLESGFEDKIRCCYEEKIANANIKQIIISPSGTRIAINGSDR------- 238 Query: 397 GSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVAL 456 + + + S G ++I K ++ + + Sbjct: 239 -----TIRQYQLIVEDNE-----SEGGSSH------SVSIELEHKYQDIINRLQWNTIFF 282 Query: 457 SN-DKQFVAV---GGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVA-TDQ 511 SN +++ G +++++ S S+ V E+ + ++ + + + Sbjct: 283 SNHSGEYLVASAHGSSAHDLYLWETSSGSLVRVLE-GADEELLDIDWNFYSMRIASNGFE 341 Query: 512 SRKVIPYSV 520 S V +S+ Sbjct: 342 SGWVYMWSI 350 Score = 69.5 bits (168), Expect = 4e-12, Method: Composition-based stats. Identities = 52/325 (16%), Positives = 99/325 (30%), Gaps = 38/325 (11%) Query: 21 AVVLGNTPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQ----TTVAKTSPSGYYCA 75 AV + +P GD + + + SL + HS S G Y Sbjct: 30 AVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSNDGRYLW 89 Query: 76 SGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEG--------RER 127 S ++WD TQ T + F GP+ + I V E +R Sbjct: 90 SSGRDWYAKLWDMTQPTKCFQQYK--FDGPLWSCHVVRWNVCIVTVVEEPTAYVLTLTDR 147 Query: 128 FGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF--EGPPF----- 180 F + +++G + + P+ II+G+ + F + Sbjct: 148 QNAFHCFPLLEQDQDISGHGYTLVAC-PHPTIESIIITGTSKGWINAFQLDLESGFEDKI 206 Query: 181 KFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNG--VDGTKTGVFEDDSLKNVAH 238 + + + +P G+ A G D TI Y D G + H Sbjct: 207 RCCYEEKIANANIKQIIISPSGTRIAINGSDRTIRQYQLIVEDNESEGGSSHSVSIELEH 266 Query: 239 S--GSVFGLTWSP------DGTKIAS---ASADKTIKIWNVATLKVEKTIPVGTRIEDQQ 287 + L W+ G + + S+ + +W ++ + + + G E Sbjct: 267 KYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSSGSLVRVLE-GADEELLD 325 Query: 288 LGIIWTKQALVSISAN-GFINFVNP 311 + + + S G++ + Sbjct: 326 IDWNFYSMRIASNGFESGWVYMWSI 350 Score = 69.5 bits (168), Expect = 4e-12, Method: Composition-based stats. Identities = 17/115 (14%), Positives = 40/115 (34%), Gaps = 3/115 (2%) Query: 434 IAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTI---VH 490 + Y + + + CV S ++AVG + + +Y + + H Sbjct: 13 LKEYPEKLTHTLEVPVAAVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAH 72 Query: 491 PAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWS 545 + SV +SN+G +L ++ + + + + + V W+ Sbjct: 73 TRSVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWN 127 Score = 66.0 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 24/96 (25%), Positives = 39/96 (40%), Gaps = 1/96 (1%) Query: 496 SVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTF-HTAKVACVSWSPDNVRLATG 554 V FS G +L + +I Y + + +A + + HT V V WS D L + Sbjct: 32 CVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSNDGRYLWSS 91 Query: 555 SLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWL 590 D +W+M +P+ K + S + V W Sbjct: 92 GRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWN 127 Score = 51.4 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 24/95 (25%), Positives = 44/95 (46%), Gaps = 3/95 (3%) Query: 517 PYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIK 576 P+ V + T++ A V CV +SP LA G + ++I+++M+ ++ Sbjct: 9 PFGVLKEYPEKLTHTLEVPVAAV-CVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGT 67 Query: 577 G-AHAMSSVNSVIWL-NETTIVSAGQDSNIKFWNV 609 SV SV W + + S+G+D K W++ Sbjct: 68 HSGAHTRSVQSVCWSNDGRYLWSSGRDWYAKLWDM 102 Score = 37.9 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 31/279 (11%), Positives = 74/279 (26%), Gaps = 47/279 (16%) Query: 329 ALSSSADGKTLFSADAEGHINSWDISTGISNRVF---PDVHATMITGIKTTSKGDLFTVS 385 + S G L + G I +D+ + + H + + ++ G Sbjct: 32 CVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSNDGRYL--- 88 Query: 386 WDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEV 445 SG D + + DG ++S + Sbjct: 89 ----------WSSGRDWYAKLWDMTQPTKCFQQYKFDG-----------PLWSCHVVRWN 127 Query: 446 PISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNN-GA 504 V + + + + H + L + + + I + Sbjct: 128 VC---IVTVVEEPTAYVLTLTDRQNAFHCFPL----LEQDQDISGHGYTLVACPHPTIES 180 Query: 505 FLVATDQSRKVIPY--SVANNF--ELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSV 560 ++ + + + + F ++ A + + SP R+A D ++ Sbjct: 181 IIITGTSKGWINAFQLDLESGFEDKIRCCYEEKIANANIKQIIISPSGTRIAINGSDRTI 240 Query: 561 IVWNM-------NKPSDHPIIIKGAHAMSS-VNSVIWLN 591 + + S H + I+ H +N + W Sbjct: 241 RQYQLIVEDNESEGGSSHSVSIELEHKYQDIINRLQWNT 279 >5WLC-LS nrPDB Length = 594 Score = 79.5 bits (194), Expect = 4e-15, Method: Composition-based stats. Identities = 62/394 (15%), Positives = 133/394 (33%), Gaps = 55/394 (13%) Query: 184 STFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVF 243 ++ H+ + S+ ++P L + G D T+ +Y+ T V + + + + + Sbjct: 243 ASHPSHSA-IQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFY 301 Query: 244 GLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALV-SISA 302 + + I +A + + W+++ + + + ++ ++ ++ S Sbjct: 302 TSLSNQNQQNIFTAGRRRYMHSWDLS----LENLTHSQTAKIEKFSRLYGHESTQRSFEN 357 Query: 303 NGFINFVNPELGSI--DQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNR 360 + N + S+ + G+N I L S G L EG I T Sbjct: 358 FKVAHLQNSQTNSVHGIVLLQGNNGWINILH-STSGLWLMGCKIEGVI------TDFCID 410 Query: 361 VFPDVHATMIT-GIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAV 419 P T I + G+++ + + V+ Sbjct: 411 YQPISRGKFRTILIAVNAYGEVWEFDLNKNGHVIRRWKD--------------------- 449 Query: 420 SADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSG 479 I G T + S + +++AVG + V++Y + Sbjct: 450 --------QGGVGITKIQVGGGTTTTCPALQISKIK---QNRWLAVGSESGFVNLYDRNN 498 Query: 480 ASVSEVKTIVH-----PAEITSVAFSNNGAFLVATDQSRK--VIPYSVANNFELAHTNSW 532 A S T V I+++ FS +G L ++ K + + + ++ + Sbjct: 499 AMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTS 558 Query: 533 TFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMN 566 KV V++SP LA G+ V +W +N Sbjct: 559 GTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLN 592 Score = 61.0 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 42/354 (11%), Positives = 96/354 (27%), Gaps = 64/354 (18%) Query: 57 EHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISW----- 111 HS PS +G +RI+ T+ L T++ + P++ ++ Sbjct: 247 SHS-AIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLS 305 Query: 112 DSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNT 171 + + I G R R+ H + + T + + + S ++ Sbjct: 306 NQNQQNIFTAG--RRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSF----ENFK 359 Query: 172 VAIFEGPPFKFKS---TFGEHTKFVHSVRYNPDGSLF------------------ASTGG 210 VA + + +++ + + G S G Sbjct: 360 VAHLQNSQTNSVHGIVLLQGNNGWINILH-STSGLWLMGCKIEGVITDFCIDYQPISRGK 418 Query: 211 DGTIVL--------YN------------GVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD 250 TI++ + D G+ + + ++ Sbjct: 419 FRTILIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQ 478 Query: 251 GTKIASASADKTIKIWNVATLKVEKTIPVGTRI-----EDQQLGIIWTKQALVSIS--AN 303 +A S + +++ T + L Q L S Sbjct: 479 NRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVK 538 Query: 304 GFINFVNPELGSI---DQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIS 354 + V+ S+ +T+++ S G L + +G + W ++ Sbjct: 539 DALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLN 592 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 17/121 (14%), Positives = 44/121 (36%), Gaps = 12/121 (9%) Query: 159 RPFRIISGSDDNTVAIFEGPP------FKFKSTFGEHTKFVHSVRYNPDGSLF--ASTGG 210 + + GS+ V +++ + + T + +++++PDG + AS Sbjct: 478 QNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAV 537 Query: 211 DGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT 270 + L + + + G V + +SP G +A + +++W + Sbjct: 538 KDALRLVHLPSCSVFSNWPTSGTPL----GKVTSVAFSPSGGLLAVGNEQGKVRLWKLNH 593 Query: 271 L 271 Sbjct: 594 Y 594 Score = 38.3 bits (87), Expect = 0.011, Method: Composition-based stats. Identities = 11/31 (35%), Positives = 14/31 (45%) Query: 60 HQTTVAKTSPSGYYCASGDVHGNVRIWDTTQ 90 + T SPSG A G+ G VR+W Sbjct: 563 GKVTSVAFSPSGGLLAVGNEQGKVRLWKLNH 593 Score = 37.5 bits (85), Expect = 0.018, Method: Composition-based stats. Identities = 15/91 (16%), Positives = 38/91 (41%), Gaps = 5/91 (5%) Query: 524 FELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKG--AHAM 581 L N+ + + +S+ P L TG D ++ +++++ ++H + + Sbjct: 236 VRLKDANASHPSHSAIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPI 295 Query: 582 SSVNSVIWL---NETTIVSAGQDSNIKFWNV 609 + L N+ I +AG+ + W++ Sbjct: 296 QTCTFYTSLSNQNQQNIFTAGRRRYMHSWDL 326 >5A9Q-7 nrPDB Length = 360 Score = 75.7 bits (184), Expect = 5e-14, Method: Composition-based stats. Identities = 52/346 (15%), Positives = 110/346 (31%), Gaps = 54/346 (15%) Query: 273 VEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELG---SIDQVRYGHNKAITA 329 V ++I + + + + + + S++ + + H+ ++ Sbjct: 3 VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62 Query: 330 LSSSAD--GKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWD 387 ++ + G+ L S + W+ G SN W Sbjct: 63 VTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRG------------------QSHWV 104 Query: 388 DHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPI 447 +V + S D A + + SADG + + + + E+ Sbjct: 105 KRTTLVDSRTSVTDVKFAPKHM---GLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISC 161 Query: 448 SYNSSCVALSNDKQ-----FVAVGGQDS------KVHVYKLSGASVSEVKTIVH---PAE 493 + SC++ + +AVG DS KV +++ + + K Sbjct: 162 KLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDP 221 Query: 494 ITSVAFSNN--GAFLVATDQSRKVIPYSVA------------NNFELAHTNSWTFHTAKV 539 + +AF+ N +F + ++ V +++ FE+ + H ++V Sbjct: 222 VHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQV 281 Query: 540 ACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVN 585 VSW+ LA+ D V +W N + S VN Sbjct: 282 WRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVN 327 Score = 71.8 bits (174), Expect = 7e-13, Method: Composition-based stats. Identities = 38/337 (11%), Positives = 92/337 (27%), Gaps = 52/337 (15%) Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWT---- 293 H + +++ G ++A+ S+D+++K+W+ + + W Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70 Query: 294 KQALVSISANGFINFVNPELGSIDQVRYGHNKA------------ITALSSSAD--GKTL 339 Q L S S + +G + G + +T + + G L Sbjct: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130 Query: 340 FSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSG 399 + A+G + A + + S + S Sbjct: 131 ATCSADGIVRI--------------YEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSR 176 Query: 400 VDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSND 459 S S P +A + + ++ Y+ + N Sbjct: 177 AHSPMIAVGSDDSSPNAMA-----KVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNL 231 Query: 460 KQ---FVAVGGQDSKVHVYKLSGASVSEVKTIV------------HPAEITSVAFSNNGA 504 + +A+ +D ++ K ++ H +++ V+++ G Sbjct: 232 GRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGT 291 Query: 505 FLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVAC 541 L ++ V + T + + V Sbjct: 292 VLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVNG 328 Score = 69.9 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 46/291 (15%), Positives = 85/291 (29%), Gaps = 51/291 (17%) Query: 24 LGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTE----HSHQTTVAKTSPS--GYYCASG 77 + G ++ C+ V S + T HS + G AS Sbjct: 18 VSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVLASC 77 Query: 78 DVHGNVRIWDTTQTTHILKTTIPVF----------SGPVKDISWDSE--SKRIAAVGEGR 125 +W+ K V D+ + + +A Sbjct: 78 SFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADG 137 Query: 126 ----ERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPF----RIISGSDDNT------ 171 V + ++ + + + + PS I GSDD++ Sbjct: 138 IVRIYEAPDVMNLSQWSLQHEIS-CKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAK 196 Query: 172 VAIFEGPPFKFK----STFGEHTKFVHSVRYNPDGS----LFASTGGDGTIVLYNGV--- 220 V IFE K T T VH + + P+ + A D + ++ Sbjct: 197 VQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD--VRIFTLKPVR 254 Query: 221 -----DGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIW 266 G T + H+ V+ ++W+ GT +AS+ D +++W Sbjct: 255 KELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305 Score = 57.6 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 48/275 (17%), Positives = 87/275 (31%), Gaps = 52/275 (18%) Query: 15 RTARGTAVVLGNT--PAGDKIQYCNGTSVYTVPVGSLTDT-EIYTEHSH----------- 60 +T G+ + G + C+ V + ++ + SH Sbjct: 54 KTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSR 113 Query: 61 -QTTVAKTSPS--GYYCASGDVHGNVRIWDTTQTTHILKTTIPVF---SGPVKDISWDSE 114 T K +P G A+ G VRI++ ++ + ++ ISW+ Sbjct: 114 TSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPS 173 Query: 115 SKR----IAAVGEGRERFG-----HVFLFDTGTSNG----NLTGQARAMNSVDFKPSRPF 161 S R + AVG +F ++ T L ++ + F P+ Sbjct: 174 SSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGR 233 Query: 162 RI-ISGSDDNTVAIFEGPPFK---------------FKSTFGEHTKFVHSVRYNPDGSLF 205 I V IF P + + F H V V +N G++ Sbjct: 234 SFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVL 293 Query: 206 ASTGGDGTIVLYNGV---DGTKTGVFEDDSLKNVA 237 AS+G DG + L+ + TG+ + + Sbjct: 294 ASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVNG 328 Score = 55.3 bits (131), Expect = 8e-08, Method: Composition-based stats. Identities = 49/331 (14%), Positives = 99/331 (29%), Gaps = 64/331 (19%) Query: 318 QVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTS 377 + H I +S G+ + + ++ + WD S D H T T Sbjct: 6 SIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSES------GDWHCTASW---KTH 56 Query: 378 KGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIY 437 G ++ V+W D + AV ++ V + Sbjct: 57 SGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEI----------------VGESNDKLRGQ 100 Query: 438 SH--GKLTEVPISYNSSCVALSND--KQFVAVGGQDSKVHVYKLSGASVSEVKTIVH--- 490 SH + T V + + V + +A D V +Y+ ++ H Sbjct: 101 SHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEIS 160 Query: 491 -PAEITSVAFSNNGAF-----LVATDQSR------KVIPYSV-ANNFELAHTNSWTFHTA 537 + ++++ + + + KV + N + A + T Sbjct: 161 CKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTD 220 Query: 538 KVACVSWSPD----NVRLATGSLDNSVIVWNMNKPSDHPIIIKGA------------HAM 581 V ++++P+ LA + D V ++ + G + Sbjct: 221 PVHDIAFAPNLGRSFHILAIATKD--VRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHN 278 Query: 582 SSVNSVIWL-NETTIVSAGQDSNIKFWNVPF 611 S V V W T + S+G D ++ W + Sbjct: 279 SQVWRVSWNITGTVLASSGDDGCVRLWKANY 309 >3EI3-B nrPDB Length = 383 Score = 75.7 bits (184), Expect = 6e-14, Method: Composition-based stats. Identities = 54/299 (18%), Positives = 96/299 (32%), Gaps = 62/299 (20%) Query: 61 QTTVAKTSPSG-YYCASGDVHGNVRIWDTTQTTHI------------------------- 94 + T + P+ A G G++ +WD Sbjct: 75 RVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQFNTNQL 134 Query: 95 ------LKTTIPVFSGPVKDI-----SWD--------SESKRIAAVGEGRERFGHVFLFD 135 TT+ FSG V + SWD S S+++ A G+ R + L Sbjct: 135 FVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQMLATGDSTGRLLLLGLDG 194 Query: 136 TGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGE---HTKF 192 L + +F P + + + S D TV +++ K K+++ H K Sbjct: 195 HEIFKEKL--HKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKP 252 Query: 193 VHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG 251 V++ +NP D + +T I +Y+ D +K + H + TW P Sbjct: 253 VNAAYFNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKA-TWHPMY 311 Query: 252 TKIASA---------SADKTIKIWNVATLKVEKTIPVGTRIEDQQLG-IIWTKQALVSI 300 I + + +TI I++ + + + L T L S Sbjct: 312 DLIVAGRYPDDQLLLNDKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSPTGDVLASG 370 Score = 55.6 bits (132), Expect = 6e-08, Method: Composition-based stats. Identities = 42/361 (11%), Positives = 97/361 (26%), Gaps = 45/361 (12%) Query: 131 VFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFG--E 188 + + + + R + S+++ P+ P + GS + +++ S Sbjct: 57 IRSLKSYKLHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMG 116 Query: 189 HTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW 247 + +++N + + + G L + G+ VF + Sbjct: 117 PGDAITGMKFNQFNTNQLFVSSIRGATTLRDF-SGSVIQVFAKTDSW----DYWYCCVDV 171 Query: 248 SPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQAL-VSISANGFI 306 S +A+ D T ++ + E + + L + S + + Sbjct: 172 SVSRQMLATG--DSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATV 229 Query: 307 NFVNPELGSIDQVRYG---HNKAITALSSSA-DGKTLFSADAEGHINS---WDISTGISN 359 + H K + A + D L + D I +D S Sbjct: 230 KLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQI 289 Query: 360 RVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAV 419 + P +T IK +W ++ AG + Sbjct: 290 IIHPHRQFQHLTPIK---------ATWHPMYDLIVAGR---YPDDQLLLNDKRTIDIYDA 337 Query: 420 SADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSG 479 ++ G + +L + + S S +A G + ++ Sbjct: 338 NSGGLVH--------------QLRDPNAAGIISLNKFSPTGDVLASG-MGFNILIWNRED 382 Query: 480 A 480 Sbjct: 383 T 383 Score = 54.1 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 43/207 (20%), Positives = 70/207 (33%), Gaps = 6/207 (2%) Query: 376 TSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIA 435 + GD+ +D K G G + L VS+ + Sbjct: 93 SKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQFNTNQLFVSSIRGATTLRDFSGSV 152 Query: 436 IYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEIT 495 I K Y CV +S +Q +A G DS + L K +H A++T Sbjct: 153 IQVFAKTDSWDYWY--CCVDVSVSRQMLATG--DSTGRLLLLGLDGHEIFKEKLHKAKVT 208 Query: 496 SVAFSNNGAFLVATDQ-SRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLAT 553 F+ +L+AT V + + N + + H V ++P D+ +L T Sbjct: 209 HAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTDSTKLLT 268 Query: 554 GSLDNSVIVWNMNKPSDHPIIIKGAHA 580 N + V++ S II H Sbjct: 269 TDQRNEIRVYSSYDWSKPDQIIIHPHR 295 Score = 46.0 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 49/349 (14%), Positives = 102/349 (29%), Gaps = 65/349 (18%) Query: 239 SGSVFGLTWSP-DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK--- 294 V L W P T +A S I +W+ ++ + + G D G+ + + Sbjct: 73 DRRVTSLEWHPTHPTTVAVGSKGGDIILWDYD-VQNKTSFIQGMGPGDAITGMKFNQFNT 131 Query: 295 QALVSISANGFINFVNPELGSIDQVRYGHNKAIT---ALSSSADGKTLFSADAEGHINSW 351 L S G + GS+ QV + + S + L + + Sbjct: 132 NQLFVSSIRGATTLRDF-SGSVIQVFAKTDSWDYWYCCVDVSVSRQMLATG--DSTGRLL 188 Query: 352 DISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLS 411 + +H +T + + D + S VD++ + + Sbjct: 189 LLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMAT------------SSVDATVKLWD--- 233 Query: 412 SQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSN-DKQFVAVGGQDS 470 L D + +A P + + D + Q + Sbjct: 234 -----LRNIKDKNSYIAEM---------------PHEKPVNAAYFNPTDSTKLLTTDQRN 273 Query: 471 KVHVYKLSGASVSEV------KTIVHPAEITSVAFSNNGAFLVAT---------DQSRKV 515 ++ VY S + + H I + + +VA + R + Sbjct: 274 EIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKA-TWHPMYDLIVAGRYPDDQLLLNDKRTI 332 Query: 516 IPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWN 564 Y + + ++ +SP LA+G + ++++WN Sbjct: 333 DIYDANSGGLVHQLRDPNA-AGIISLNKFSPTGDVLASG-MGFNILIWN 379 Score = 44.1 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 39/233 (16%), Positives = 75/233 (32%), Gaps = 18/233 (7%) Query: 388 DHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHG----KLT 443 D GG K + ++ + C + I S T Sbjct: 9 DENLYFQGGGRTGGQKKVGQTSILHYIYKSSLGQSIHAQLRQCLQEPFIRSLKSYKLHRT 68 Query: 444 EVPISYNSSCVALSNDKQF-VAVGGQDSKVHVYKLS-GASVSEVKTIVHPAEITSV---A 498 P + + VAVG + + ++ S ++ + IT + Sbjct: 69 ASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQ 128 Query: 499 FSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDN 558 F+ N F+ + + + +S + A T+SW + CV S LATG D+ Sbjct: 129 FNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSWDY---WYCCVDVSVSRQMLATG--DS 183 Query: 559 SVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNET--TIVSAGQDSNIKFWNV 609 + + D I K + V + + ++ D+ +K W++ Sbjct: 184 TGR--LLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDL 234 Score = 37.2 bits (84), Expect = 0.019, Method: Composition-based stats. Identities = 34/201 (16%), Positives = 69/201 (34%), Gaps = 11/201 (5%) Query: 412 SQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSN-DKQFVAVGGQDS 470 + P +AV + G + Y S + + + + + + + V Sbjct: 84 THPTTVAVGSKGGDIILWDYDVQNKTSF--IQGMGPGDAITGMKFNQFNTNQLFVSSIRG 141 Query: 471 KVHVYKLSGASVSEV-KTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHT 529 + SG+ + KT V S + L D + + + + Sbjct: 142 ATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQMLATGDSTGR----LLLLGLDGHEI 197 Query: 530 NSWTFHTAKVACVSWSPDNVRL-ATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVI 588 H AKV ++P L AT S+D +V +W++ D I VN+ Sbjct: 198 FKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAY 257 Query: 589 WL--NETTIVSAGQDSNIKFW 607 + + T +++ Q + I+ + Sbjct: 258 FNPTDSTKLLTTDQRNEIRVY 278 >5A9Q-2 nrPDB Length = 326 Score = 73.0 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 56/317 (17%), Positives = 96/317 (30%), Gaps = 38/317 (11%) Query: 61 QTTVAKTSP-----SGYYCASGDVH----GNVRIWDTTQT-THILKTTIP--VFSGPVKD 108 V + +P SG A G + G + I T+ V Sbjct: 18 YVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVRVDG 77 Query: 109 ISWDSESKR------IAAVGEGRERFGHVFLFDTGTSN--GNLTGQARAMNSVDFKPSRP 160 I+W E++ I + +F D N L G +N + F P Sbjct: 78 IAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPKEG 137 Query: 161 FRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSL-FASTGGDGTIVLYNG 219 I S SDD+T I+ + F H+ SV ++P+ + +GTI Y+ Sbjct: 138 QEIASVSDDHTCRIWNLEGVQTAH-FVLHSPG-MSVCWHPEETFKLMVAEKNGTIRFYDL 195 Query: 220 VDGTKTGVFEDDSLKNVAHSGSVFGLTWS-PDGTKI-ASASADKTIKIWNV-ATLKVEKT 276 + E + + + W + K+ A A D I W++ + + Sbjct: 196 LAQQAILSLESEQV-------PLMSAHWCLKNTFKVGAVAGNDWLI--WDITRSSYPQNK 246 Query: 277 IPVGTRIEDQQLGIIWTKQALVSISANGFI--NFVNPELGSIDQVRYGHNKAITALSSSA 334 PV ++ + G + F LG + G + LS Sbjct: 247 RPVHMDRACLFRWSTISENLFATTGYPGKMASQFQIHHLGHPQPILMGSVAVGSGLSWHR 306 Query: 335 DGKTLFSADAEGHINSW 351 + + W Sbjct: 307 TLPLCVIGG-DHKLLFW 322 Score = 55.3 bits (131), Expect = 7e-08, Method: Composition-based stats. Identities = 24/199 (12%), Positives = 61/199 (30%), Gaps = 20/199 (10%) Query: 423 GDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQF--------VAVGGQDSKVHV 474 G + + L +A S + + D K+ + Sbjct: 47 GTCTFQEEEADVEGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRL 106 Query: 475 Y--KLSGASVSEVKTIVHPAEITSVAFSN-NGAFLVATDQSRKVIPYSVANNFELAHTNS 531 + L + +V H I + F G + + +++ T Sbjct: 107 FTSDLQDKNEYKVLE-GHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEG----VQTAH 161 Query: 532 WTFHTAKVACVSWSPDNV-RLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWL 590 + H+ V W P+ +L + ++ +++ + I+ + + +++ L Sbjct: 162 FVLHSPG-MSVCWHPEETFKLMVAEKNGTIRFYDL--LAQQAILSLESEQVPLMSAHWCL 218 Query: 591 NETTIVSAGQDSNIKFWNV 609 T V A ++ W++ Sbjct: 219 KNTFKVGAVAGNDWLIWDI 237 Score = 54.9 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 63/400 (15%), Positives = 114/400 (28%), Gaps = 119/400 (29%) Query: 190 TKFVHSVRYNP-----DGSLFASTGGD----GTIVLYNGVDGTKTGVFEDDSLKNVAHSG 240 +VH V +NP G+L A G + GT + + +L+ H Sbjct: 16 EDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTF--QEEEADVEGIQYKTLRTFHHGV 73 Query: 241 SVFGLTWSPDGT--------KIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW 292 V G+ WSP+ K +++AD I+++ Sbjct: 74 RVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTS------------------------ 109 Query: 293 TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSA-DGKTLFSADAEGHINSW 351 + + + +V GH I L +G+ + S + W Sbjct: 110 -----------------DLQDKNEYKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIW 152 Query: 352 DISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLS 411 ++ + +V W Sbjct: 153 NLEGVQTAHFVLHS--------------PGMSVCW----------------------HPE 176 Query: 412 SQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSK 471 + +G I AI S + +VP+ C+ N + AV G D Sbjct: 177 ETFKLMVAEKNGTIRFYDLLAQQAILSL-ESEQVPLMSAHWCLK--NTFKVGAVAGNDWL 233 Query: 472 VHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNS 531 + + ++ +S + K VH +S L AT P +A+ F++ H Sbjct: 234 I--WDITRSSYPQNKRPVHMDRACLFRWSTISENLFAT----TGYPGKMASQFQIHHL-- 285 Query: 532 WTFHTAKVA--------CVSWSPDNVRLATGSLDNSVIVW 563 H + +SW G D+ ++ W Sbjct: 286 --GHPQPILMGSVAVGSGLSWHRTLPLCVIGG-DHKLLFW 322 >3I2N-A nrPDB Length = 357 Score = 73.0 bits (177), Expect = 4e-13, Method: Composition-based stats. Identities = 45/221 (20%), Positives = 82/221 (37%), Gaps = 33/221 (14%) Query: 74 CASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDI-------SWDSESKRIAAVGEGRE 126 +G G V++WD Q + PV +D +++ E + + A + Sbjct: 132 IVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYD--- 188 Query: 127 RFGHVFLFDTGT-SNGNLTGQARAMNSVDFKPS--RPFRIISGSDDNTVAIFEGPPFKFK 183 G + LFD + T + S++F ++++ S + +F+ Sbjct: 189 -NGDIKLFDLRNMALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPT 247 Query: 184 STF-----GEHTKFVHSVRYNPDGS-LFASTGGDGTIVLYNGV----------DGTKTGV 227 F H V VR+ P LF + GG G + L+ +G + GV Sbjct: 248 KGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGV 307 Query: 228 FEDDSLKN--VAHSGSVFGLTWSPDGTKIA-SASADKTIKI 265 SL + + L WSPD + +S D+T+++ Sbjct: 308 AGSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRV 348 Score = 68.4 bits (165), Expect = 8e-12, Method: Composition-based stats. Identities = 57/383 (14%), Positives = 120/383 (31%), Gaps = 58/383 (15%) Query: 1 MSEFSQTALFPSLPRTARGTAVVLGNTPAGDKIQ----YCNGTSVYTVPVGSLTDTEIYT 56 MS F + + + + T P K + GT V + D ++ Sbjct: 1 MSAFEKPQIIAHIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLR 60 Query: 57 E--HSHQTTVAKT---SPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISW 111 E + S Y A+GD GN+ IW+ + ++ + I Sbjct: 61 EIEKAKPIKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEMPVY-SVKGHKEIINAIDG 119 Query: 112 DSESKRIAAVGE--GRERFGHVFLFDTGTSNGNLTG-------QARAMNSVDF--KPSRP 160 E R G V ++D + + R +V F ++ Sbjct: 120 IGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQE 179 Query: 161 FRIISGSDDN-TVAIFEGPPFKF--KSTFGEHTKFVHSVRYNPDG---SLFASTGGDGTI 214 R++ DN + +F+ ++ V S+ ++ + +T +G Sbjct: 180 ERVVCAGYDNGDIKLFDLRNMALRWETNIK---NGVCSLEFDRKDISMNKLVATSLEGKF 236 Query: 215 VLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP-DGTKIASASADKTIKIWNVATLKV 273 +++ T F S+ AH +V+ + P + +A + +W + Sbjct: 237 HVFDMRTQHPTKGFA--SVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYE-YPI 293 Query: 274 EKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSS 333 +++ IE G + Q V++S + I++L S Sbjct: 294 QRSKKDSEGIEMGVAGSVSLLQN-VTLS----------------------TQPISSLDWS 330 Query: 334 ADGKTLFSADA-EGHINSWDIST 355 D + L + + + ++ Sbjct: 331 PDKRGLCVCSSFDQTVRVLIVTK 353 Score = 63.7 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 47/370 (12%), Positives = 108/370 (29%), Gaps = 65/370 (17%) Query: 229 EDDSLKNVAHSGSVFGLTWSPDGTKIAS----ASADKTIKIWNVATLKVEKTIPVGTRIE 284 + + + +VF W P K + A I+++ + ++ + Sbjct: 8 QIIAHIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKP 67 Query: 285 DQQLGIIWTK---QALVSISANGFINFVNPELGSIDQV-RYGHNKAITALSSSADGKT-- 338 + T + L + G ++ N E + GH + I A+ Sbjct: 68 IKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGE 127 Query: 339 ----LFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVP 394 + + +G + WD D + ++ +K D +TV++ + Sbjct: 128 GAPEIVTGSRDGTVKVWDP-------RQKDDPVANMEPVQGENKRDCWTVAFGN------ 174 Query: 395 AGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCV 454 + + + D +++A+ + S Sbjct: 175 --------------AYNQEERVVCAGYDNGDIKLFDLRNMALRWETNIKNGVCSLEFDRK 220 Query: 455 ALSNDKQFVAVGGQDSKVHVYKLSGASVS----EVKTIVHPAEITSVAFSN-NGAFLVAT 509 +S +K + + K HV+ + + V H + + V N + Sbjct: 221 DISMNK--LVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTA 278 Query: 510 DQSRKVIPYSVANNFE----------------LAHTNSWTFHTAKVACVSWSPDNVRLAT 553 + + + + ++ + T T ++ + WSPD L Sbjct: 279 GGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLCV 338 Query: 554 GSL-DNSVIV 562 S D +V V Sbjct: 339 CSSFDQTVRV 348 Score = 58.7 bits (140), Expect = 7e-09, Method: Composition-based stats. Identities = 47/410 (11%), Positives = 105/410 (25%), Gaps = 106/410 (25%) Query: 141 GNLTGQARAMNSVDFKPSRPFRIISGSD---DNTVAIFEGPPFKFKSTFG-EHTKFVHSV 196 G + + P + G+ + ++E K E K + Sbjct: 12 HIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCG 71 Query: 197 RY---NPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG-- 251 + + A+ G + ++N E H + + Sbjct: 72 TFGATSLQQRYLATGDFGGNLHIWNLEAP------EMPVYSVKGHKEIINAIDGIGGLGI 125 Query: 252 ----TKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFIN 307 +I + S D T+K+W+ + +D + + + Sbjct: 126 GEGAPEIVTGSRDGTVKVWD------------PRQKDDPVANMEPVQ-------GENKRD 166 Query: 308 FVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHA 367 G+ + + + + + + G I +D+ Sbjct: 167 CWTVAFGN---------------AYNQEERVVCAGYDNGDIKLFDLR------------- 198 Query: 368 TMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAV 427 + W+ ++K S K S +A S +G V Sbjct: 199 -------------NMALRWETNIK-------NGVCSLEFDRKDISMNKLVATSLEGKFHV 238 Query: 428 AACYKHIAIYSHGKLTEVPISYNSSCVA-LSNDKQFVAVGGQDSKVHVYKLS-------- 478 ++E V L +++ G +H++K Sbjct: 239 FDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKK 298 Query: 479 ---------GASVSEVKT-IVHPAEITSVAFSNNGAFL-VATDQSRKVIP 517 SVS ++ + I+S+ +S + L V + + V Sbjct: 299 DSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRV 348 Score = 54.9 bits (130), Expect = 9e-08, Method: Composition-based stats. Identities = 29/189 (15%), Positives = 63/189 (33%), Gaps = 21/189 (11%) Query: 440 GKLTEVPISYNSSCVALSNDKQFVAVGGQ---DSKVHVYKLSGASVSEVKTIVHPAEITS 496 + + C + +FV +G + +Y++ + ++ I I Sbjct: 11 AHIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKC 70 Query: 497 VAF---SNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPD------ 547 F S +L D + +++ S H + + Sbjct: 71 GTFGATSLQQRYLATGDFGGNLHIWNLEA--PEMPVYSVKGHKEIINAIDGIGGLGIGEG 128 Query: 548 NVRLATGSLDNSVIVWN---MNKPSDHPIIIKGAHAMSSVNSV---IWLNETTIVSAGQD 601 + TGS D +V VW+ + P + ++G + + E +V AG D Sbjct: 129 APEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYD 188 Query: 602 S-NIKFWNV 609 + +IK +++ Sbjct: 189 NGDIKLFDL 197 Score = 48.7 bits (114), Expect = 7e-06, Method: Composition-based stats. Identities = 21/176 (11%), Positives = 51/176 (28%), Gaps = 18/176 (10%) Query: 414 PLGLAVSADGDIAVAACYKHIAIYSHGKL---TEVPISYNSSCVAL---SNDKQFVAVGG 467 P G+ A + HG L E+ + C S ++++A G Sbjct: 28 PCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFGATSLQQRYLATGD 87 Query: 468 QDSKVHVYKLSGASVSEVKTIVHPAEITS------VAFSNNGAFLVATDQSRKVIPYSVA 521 +H++ L + H I + + +V + V + Sbjct: 88 FGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGTVKVWDPR 147 Query: 522 NNFELAHTNSWTFHTAKVAC--VSW----SPDNVRLATGSLDNSVIVWNMNKPSDH 571 + K C V++ + + + G + + ++++ + Sbjct: 148 QKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMALR 203 >5AMS-A nrPDB Length = 431 Score = 72.6 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 55/385 (14%), Positives = 117/385 (30%), Gaps = 41/385 (10%) Query: 53 EIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWD 112 + +H+ P+ +G +W + T+ + V S+ Sbjct: 59 TYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFT 118 Query: 113 SESKRIAAVGEGRERFGHVFLF--DTGTSNGNLTGQARAMNSVDF---KPSRPFRIISGS 167 SE + + G V + G + L Q + + + + P+ G+ Sbjct: 119 SEGGFLVTA----DMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGA 174 Query: 168 DDNTVAIF--EGPPFKFKSTFGE--HTKFVHSVRYNPDGS-----LFASTGGDGTIVLYN 218 D +V + + H + + + D TIV +N Sbjct: 175 TDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 Query: 219 GVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP------DGTKIASASADKTIKIWNVATLK 272 G + F+ + L+ +P + +A S + + + N Sbjct: 235 CFTGQQL--FKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGG 292 Query: 273 VEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYG-----H---- 323 + ++ +Q + + +++ S S+ + + G I H Sbjct: 293 AILHLSTVIELKPEQDELDASIESI-SWSSKFSLMAIGLVCGEILLYDTSAWRVRHKFVL 351 Query: 324 NKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFT 383 ++T L D LF++ G + ++ TG V + ++ I + Sbjct: 352 EDSVTKLMFDNDD--LFASCINGKVYQFNARTGQEKFVCVGHNMGVLDFILL---HPVAN 406 Query: 384 VSWDDHLKVVPAGGSGVDSSKAVAN 408 + KV+ AG GV V N Sbjct: 407 TGTEQKRKVITAGDEGVSLVFEVPN 431 Score = 37.2 bits (84), Expect = 0.022, Method: Composition-based stats. Identities = 27/288 (9%), Positives = 77/288 (26%), Gaps = 34/288 (11%) Query: 313 LGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD--ISTGISNRVFPDVHATMI 370 + H ++ A+ + + + + + W ++I Sbjct: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVI 113 Query: 371 TGIKTTSKGDLFTVSWDDHLKV---------VPAGGSGVDSSKAVANKLSSQPLGLAVSA 421 + T+ G L T + V + + V K Sbjct: 114 SCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFG 173 Query: 422 DGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVA------LSNDKQFVAVGGQDSKVHVY 475 D +V + S +L + + + + DS + + Sbjct: 174 ATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAW 233 Query: 476 KLSGA----SVSEVKTIVHPAEITSVAFSN------NGAFLVATDQSRKVIPYSVANNFE 525 +++ + A S++ + N + + + + N Sbjct: 234 NCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGA 293 Query: 526 LAHTNSWTFHTAK-------VACVSWSPDNVRLATGSLDNSVIVWNMN 566 + H ++ + + +SWS +A G + +++++ + Sbjct: 294 ILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTS 341 Score = 36.0 bits (81), Expect = 0.043, Method: Composition-based stats. Identities = 18/134 (13%), Positives = 41/134 (30%), Gaps = 11/134 (8%) Query: 476 KLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFH 535 +S S++ H + ++ N + ++ + T + Sbjct: 52 DMSNNSLTYF--DKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGT-LTGY 108 Query: 536 TAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTI 595 V S++ + L T + V+V + K A M V ++WL Sbjct: 109 GESVISCSFTSEGGFLVTADMSGKVLV---HMGQKGGAQWKLASQMQEVEEIVWLKTHPT 165 Query: 596 VS-----AGQDSNI 604 ++ D ++ Sbjct: 166 IARTFAFGATDGSV 179 Score = 32.9 bits (73), Expect = 0.37, Method: Composition-based stats. Identities = 12/80 (15%), Positives = 24/80 (30%) Query: 527 AHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNS 586 + HT V + P+ + TG DN +W + + S ++ Sbjct: 56 NSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISC 115 Query: 587 VIWLNETTIVSAGQDSNIKF 606 +V+A + Sbjct: 116 SFTSEGGFLVTADMSGKVLV 135 >5LTD-A nrPDB Length = 525 Score = 69.5 bits (168), Expect = 4e-12, Method: Composition-based stats. Identities = 34/217 (15%), Positives = 69/217 (31%), Gaps = 36/217 (16%) Query: 82 NVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNG 141 + I+D + P + +S SE+ +A + Sbjct: 138 TIYIYDINNMRLLHTIETPSNPNGLIALSPSSENNYLAYPSPQK---------------- 181 Query: 142 NLTGQARAMNSVDFKPSRPFRIIS---GSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRY 198 + P + S + V IF+ + S H + ++ Sbjct: 182 -----------LAPNPQTEVTLHSNPQTVRNGDVIIFDAKTLQPTSVIEAHRTSLAAIAL 230 Query: 199 NPDGSLFASTGGDGT-IVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASA 257 + DG L A+ GT I +++ G K F + ++ L +SPD + ++ Sbjct: 231 SKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPT-----KIYSLAFSPDNRFVIAS 285 Query: 258 SADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK 294 SA +T+ I+ + + TI + + Sbjct: 286 SATETVHIFRLGEEEAANTIKSANKKARLTKAQVPNP 322 Score = 56.0 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 45/323 (13%), Positives = 96/323 (29%), Gaps = 82/323 (25%) Query: 74 CASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRE---RFGH 130 C S +I++ + S + ++ + S I +GE R Sbjct: 45 CVSVGYSNGYKIYNCEPFGQCYSKSDG--SIGIVEMLFSSSLLAIVGMGEQHSLSPRRLK 102 Query: 131 VFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHT 190 + T+ LT A+ +V R ++ + T+ I++ + T + Sbjct: 103 IINTKRQTTICELTF-PGAILAVKLNRERLVVLL----EETIYIYDINNMRLLHTIETPS 157 Query: 191 KFVHSVRYNPDG--SLFASTG---------------------GDGTIVLYNGVDGTKTGV 227 + +P + A +G +++++ T V Sbjct: 158 NPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQTVRNGDVIIFDAKTLQPTSV 217 Query: 228 FEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTI-KIWNVATLKVEKTIPVGTRIEDQ 286 E AH S+ + S DG +A+AS TI ++++VAT Sbjct: 218 IE-------AHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATG--------------- 255 Query: 287 QLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEG 346 I G+ I +L+ S D + + ++ A Sbjct: 256 -------------------IKLYQFRRGTYPTK-------IYSLAFSPDNRFVIASSATE 289 Query: 347 HINSWDISTGISNRVFPDVHATM 369 ++ + + + + Sbjct: 290 TVHIFRLGEEEAANTIKSANKKA 312 Score = 56.0 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 21/125 (16%), Positives = 46/125 (36%), Gaps = 3/125 (2%) Query: 468 QDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKV-IPYSVANNFEL 526 ++ V ++ + V H + ++A S +G L + +SVA +L Sbjct: 200 RNGDVIIFDAKTLQPTSVIE-AHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKL 258 Query: 527 AHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNS 586 T+ T K+ +++SPDN + S +V ++ + + I + Sbjct: 259 YQFRRGTYPT-KIYSLAFSPDNRFVIASSATETVHIFRLGEEEAANTIKSANKKARLTKA 317 Query: 587 VIWLN 591 + Sbjct: 318 QVPNP 322 Score = 47.9 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 18/107 (16%), Positives = 42/107 (39%), Gaps = 6/107 (5%) Query: 431 YKHIAIYSHGKLTEVPI----SYNSSCVALSNDKQFVAVGGQDSKV-HVYKLSGA-SVSE 484 + I+ L + + + +ALS D +A + V+ ++ + + Sbjct: 201 NGDVIIFDAKTLQPTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQ 260 Query: 485 VKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNS 531 + +P +I S+AFS + F++A+ + V + + S Sbjct: 261 FRRGTYPTKIYSLAFSPDNRFVIASSATETVHIFRLGEEEAANTIKS 307 Score = 42.6 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 29/198 (14%), Positives = 63/198 (31%), Gaps = 27/198 (13%) Query: 225 TGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIE 284 ++ + G++ + + + + ++TI I+++ +++ TI + Sbjct: 104 INTKRQTTICELTFPGAILAVKLNRERLVVL---LEETIYIYDINNMRLLHTIETPSNPN 160 Query: 285 DQQ-LGIIWTKQALVSISA---------------------NGFINFVNPELGSIDQVRYG 322 L L S NG + + + V Sbjct: 161 GLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQTVRNGDVIIFDAKTLQPTSVIEA 220 Query: 323 HNKAITALSSSADGKTLFSADAEGH-INSWDISTGISNRVF-PDVHATMITGIKTTSKGD 380 H ++ A++ S DG L +A +G I + ++TGI F + T I + + Sbjct: 221 HRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAFSPDNR 280 Query: 381 LFTVSWDDHLKVVPAGGS 398 S + G Sbjct: 281 FVIASSATETVHIFRLGE 298 Score = 41.0 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 20/137 (14%), Positives = 41/137 (29%), Gaps = 22/137 (16%) Query: 10 FPSLPRTARGTAVVLGNTPA----GDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVA 65 P+T V L + P GD I + +L T + H Sbjct: 182 LAPNPQTE----VTLHSNPQTVRNGDVIIFD---------AKTLQPTSVIEAHRTSLAAI 228 Query: 66 KTSPSGYYCASGDVHGN-VRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEG 124 S G A+ G +R++ + + + + +++ +++ + A Sbjct: 229 ALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAFSPDNRFVIASSA- 287 Query: 125 RERFGHVFLFDTGTSNG 141 V +F G Sbjct: 288 ---TETVHIFRLGEEEA 301 >3JB9-S nrPDB Length = 488 Score = 69.5 bits (168), Expect = 4e-12, Method: Composition-based stats. Identities = 47/351 (13%), Positives = 117/351 (33%), Gaps = 32/351 (9%) Query: 269 ATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAIT 328 LK V ++ TK + + + +I + ++ T Sbjct: 156 DQLKTSLRSTVEKTFQELSSKRKRTKLQPKWATDDAVSQLLQATPSTILENLE--TESTT 213 Query: 329 ALSSSA-DGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWD 387 + S + + + + DI + + ++F + V+ Sbjct: 214 SFFPSPENSSFVLCLHKDELLCL-DIQSNSTLKIFEGSALACCWLTSSK-----IAVATA 267 Query: 388 DHLKVV--PAGGSGVDSSKAVAN--KLSSQPLGLAVSADGDIAVAACYKHIAIYS-HGKL 442 D + + P SG+ S + + + L G+ +AA + I+S ++ Sbjct: 268 DAISIFEFPVSSSGLQSVGEPTSSIPIDEKVNFLQAHPSGEYLLAASNEKCYIFSLKSQV 327 Query: 443 TEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNN 502 + ++ + + +A+ D G ++ ++ ++ S + H + + ++ F N Sbjct: 328 YNITVAQHITSLAVHPDGNLFVAGLENGELRFFETSSGNELTKFGP-HSSPVKTLQFGEN 386 Query: 503 GAFLV-ATDQSRKVIPYSVANNFELA----HTNSWTFHTAKVACVSWSPDNVRLATGSLD 557 G +LV T+ + + + + + T + + S D L Sbjct: 387 GYWLVVTTNDDSDIFIWDLRKSELVQKIPLQTKVAAVSLDITSQLLVSSDGETLYVHIYV 446 Query: 558 NSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNE--TTIVSAGQDSNIKF 606 S W + +SS+++++WLNE + S + ++ Sbjct: 447 KSSKSWRCMSQT----------HVSSISNLVWLNELHQLLFSTSNGAILRL 487 Score = 59.9 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 25/204 (12%), Positives = 70/204 (34%), Gaps = 17/204 (8%) Query: 61 QTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAA 120 + + PSG Y + + + + + + T+ + ++ + Sbjct: 297 KVNFLQAHPSGEYLLAASNE---KCYIFSLKSQVYNITVAQH---ITSLAVHPDGNLF-- 348 Query: 121 VGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPF 180 V F +G + + ++ F + + +++ +DD+ + I++ Sbjct: 349 VAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKS 408 Query: 181 KFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGT-IVLYNGVDGTKTGVFEDDSLKNVAHS 239 + TK V +V + L S+ G+ + +Y + + H Sbjct: 409 ELVQKIPLQTK-VAAVSLDITSQLLVSSDGETLYVHIY-------VKSSKSWRCMSQTHV 460 Query: 240 GSVFGLTWSPDGTKIASASADKTI 263 S+ L W + ++ ++++ I Sbjct: 461 SSISNLVWLNELHQLLFSTSNGAI 484 Score = 59.1 bits (141), Expect = 6e-09, Method: Composition-based stats. Identities = 29/203 (14%), Positives = 66/203 (32%), Gaps = 16/203 (7%) Query: 105 PVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRII 164 V + + + A + ++F + N + + S+ P + Sbjct: 297 KVNFLQAHPSGEYLLAASNEK---CYIFSLKSQVYNITVAQH---ITSLAVHPDGNL-FV 349 Query: 165 SGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFA-STGGDGTIVLYNGVDGT 223 +G ++ + FE + FG H+ V ++++ +G +T D I +++ Sbjct: 350 AGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSE 409 Query: 224 KTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRI 283 + L S DG + + I+ V + K + + Sbjct: 410 LVQKIPLQTKVAAVSLDITSQLLVSSDGETLY-------VHIY-VKSSKSWRCMSQTHVS 461 Query: 284 EDQQLGIIWTKQALVSISANGFI 306 L + L+ ++NG I Sbjct: 462 SISNLVWLNELHQLLFSTSNGAI 484 Score = 58.3 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 30/203 (14%), Positives = 59/203 (29%), Gaps = 11/203 (5%) Query: 176 EGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKN 235 + F + S A D I ++ + + + Sbjct: 237 DIQSNSTLKIFEGSALACCWLT----SSKIAVATADA-ISIFEFPVSSSGLQSVGEPTSS 291 Query: 236 VAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQ 295 + V L P G + +AS +K I+++ + T+ L + Sbjct: 292 IPIDEKVNFLQAHPSGEYLLAASNEK-CYIFSLKSQVYNITVAQH----ITSLAVHPDGN 346 Query: 296 ALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTL-FSADAEGHINSWDIS 354 V+ NG + F G+ H+ + L +G L + + + I WD+ Sbjct: 347 LFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLR 406 Query: 355 TGISNRVFPDVHATMITGIKTTS 377 + P + TS Sbjct: 407 KSELVQKIPLQTKVAAVSLDITS 429 Score = 54.1 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 20/147 (13%), Positives = 51/147 (34%), Gaps = 6/147 (4%) Query: 24 LGNTPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGD-VHG 81 L P G+ S + + HS + +GY+ Sbjct: 339 LAVHPDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDS 398 Query: 82 NVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNG 141 ++ IWD ++ + K + V +S D S+ + + +G + H+++ + + Sbjct: 399 DIFIWDLRKSELVQKIPLQT---KVAAVSLDITSQLLVS-SDGETLYVHIYVKSSKSWRC 454 Query: 142 NLTGQARAMNSVDFKPSRPFRIISGSD 168 +++++ + + S S+ Sbjct: 455 MSQTHVSSISNLVWLNELHQLLFSTSN 481 >3DWL-C nrPDB Length = 377 Score = 68.7 bits (166), Expect = 7e-12, Method: Composition-based stats. Identities = 29/222 (13%), Positives = 66/222 (29%), Gaps = 23/222 (10%) Query: 110 SWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDD 169 +++S+ + + + + + + VD+ P + RI++ S D Sbjct: 18 AFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAP-KSNRIVTCSQD 76 Query: 170 NTVAIFEGPP---FKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTG 226 ++E P +K + VR++P+ FA G I + + Sbjct: 77 RNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISV-CYFEQENDW 135 Query: 227 VFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIK----------------IWNVAT 270 + + ++ L W P+ +A+ AD+ +W Sbjct: 136 WVSKHLKRPL--RSTILSLDWHPNNVLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRL 193 Query: 271 LKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPE 312 + +G + AL + + P Sbjct: 194 PFNTVCAEYPSGGWVHAVGFSPSGNALAYAGHDSSVTIAYPS 235 Score = 63.7 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 36/220 (16%), Positives = 68/220 (30%), Gaps = 36/220 (16%) Query: 158 SRPFRIISGSDDNTVAIF--EGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIV 215 S+ ++ + N V ++ +G +K TF +H K V V + P + + D Sbjct: 21 SQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDRNAY 80 Query: 216 LYN-GVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVE 274 +Y DGT L A + WSP+ K A S + I + + Sbjct: 81 VYEKRPDGTWKQTLVLLRLNRAA-----TFVRWSPNEDKFAVGSGARVISV--CYFEQEN 133 Query: 275 KTIPVGT---RIEDQQLGIIWTKQALVSIS---------ANGFINFVN------------ 310 + L + W ++ + + ++ V+ Sbjct: 134 DWWVSKHLKRPLRSTILSLDWHPNNVLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRL 193 Query: 311 PELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINS 350 P + G + A+ S G L A + + Sbjct: 194 PFNTVCAEYPSG--GWVHAVGFSPSGNALAYAGHDSSVTI 231 Score = 53.7 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 29/234 (12%), Positives = 63/234 (26%), Gaps = 30/234 (12%) Query: 49 LTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDT-TQTTHILKTTIPVFSGPVK 107 +++H T +P + N +++ T + + Sbjct: 45 WKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDRNAYVYEKRPDGTWKQTLVLLRLNRAAT 104 Query: 108 DISWDSESKRIAAVGEGRERFGHVFLF--DTGTSNGNLTGQARAMNSVDFKPSRPFRIIS 165 + W + A R F D S + S+D+ P+ + + Sbjct: 105 FVRWSPNEDKFAVGSGARVISVCYFEQENDWWVSKHLKRPLRSTILSLDWHPNN-VLLAA 163 Query: 166 GSDDNTVA----------------IFEGP---PFKFKSTFGEHTKFVHSVRYNPDGSLFA 206 G D ++ +VH+V ++P G+ A Sbjct: 164 GCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEYPSG--GWVHAVGFSPSGNALA 221 Query: 207 STGGDGTIVL-YNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASA 259 G D ++ + Y L + + L W+ + +A+ Sbjct: 222 YAGHDSSVTIAYPSAPEQPPRALITVKLSQL----PLRSLLWANESAIVAAGYN 271 Score = 52.6 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 26/148 (17%), Positives = 50/148 (33%), Gaps = 2/148 (1%) Query: 455 ALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV-HPAEITSVAFSNNGAFLVATDQSR 513 A ++ + ++V +Y+ G +T H +T V ++ +V Q R Sbjct: 18 AFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDR 77 Query: 514 KVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIV-WNMNKPSDHP 572 Y + T V WSP+ + A GS + V + + Sbjct: 78 NAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISVCYFEQENDWWV 137 Query: 573 IIIKGAHAMSSVNSVIWLNETTIVSAGQ 600 S++ S+ W +++AG Sbjct: 138 SKHLKRPLRSTILSLDWHPNNVLLAAGC 165 Score = 49.9 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 20/116 (17%), Positives = 42/116 (36%), Gaps = 5/116 (4%) Query: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLS-GASVSEVKTIVHPAEITS-VAFSNNGAFLV- 507 +CV + + QD +VY+ + + ++ + V +S N Sbjct: 58 VTCVDWAPKSNRIVTCSQDRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAV 117 Query: 508 -ATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIV 562 + + V + N++ ++ + + + W P+NV LA G D V Sbjct: 118 GSGARVISVCYFEQENDWWVSKHLKRPLR-STILSLDWHPNNVLLAAGCADRKAYV 172 Score = 46.4 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 33/288 (11%), Positives = 82/288 (28%), Gaps = 35/288 (12%) Query: 268 VATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFV--NPELGSIDQVRYGHNK 325 +AT +V +P + + V+ +A + + + H+K Sbjct: 1 MATSQVLHILPKPSYEH----AFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDK 56 Query: 326 AITALSSSADGKTLFSADAEGHINSWDIST-GISNRVFPDVH-ATMITGIKTTSKGD--- 380 +T + + + + + + ++ G + + T ++ + D Sbjct: 57 IVTCVDWAPKSNRIVTCSQDRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFA 116 Query: 381 ------LFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVA------ 428 + +V + + ++ L P + ++A A Sbjct: 117 VGSGARVISVCYFEQENDWWVSKHLKRPLRSTILSLDWHPNNVLLAAGCADRKAYVLSAY 176 Query: 429 ---------ACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHV-YKLS 478 A + + E P V S +A G DS V + Y + Sbjct: 177 VRDVDAKPEASVWGSRLPFNTVCAEYPSGGWVHAVGFSPSGNALAYAGHDSSVTIAYPSA 236 Query: 479 GASVSEVKTIVHPA--EITSVAFSNNGAFLVATDQSRKVIPYSVANNF 524 V + + S+ ++N A + A ++ + + Sbjct: 237 PEQPPRALITVKLSQLPLRSLLWANESAIVAAGYNYSPILLQGNESGW 284 Score = 45.6 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 22/114 (19%), Positives = 40/114 (35%), Gaps = 1/114 (0%) Query: 491 PAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVR 550 P AF++ V T + +V Y + H +++ H V CV W+P + R Sbjct: 11 PKPSYEHAFNSQRTEFVTTTATNQVELYE-QDGNGWKHARTFSDHDKIVTCVDWAPKSNR 69 Query: 551 LATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNI 604 + T S D + V+ + + V W + G + + Sbjct: 70 IVTCSQDRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARV 123 >4AV8-A nrPDB Length = 339 Score = 68.4 bits (165), Expect = 9e-12, Method: Composition-based stats. Identities = 51/259 (19%), Positives = 86/259 (33%), Gaps = 18/259 (6%) Query: 64 VAKTSPSGYYCA-SGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVG 122 + Y A + IWD + I + + VKD+ + S + + G Sbjct: 58 TIRMLHRTNYIAFVSTKKELLHIWDDVKKQDITRVKLD---AAVKDL-FLSREFIVVSQG 113 Query: 123 EGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKF 182 + F ++ T + G N + S F + G T + Sbjct: 114 DVISIFKFGNPWNKITEDIKFGGVCEFANGL-LVYSNEFNL--GQIHVTRLQTDAEQVVG 170 Query: 183 KSTF-GEHTKFVHSVRYNPDGSLFASTGGDGT-IVLYNGVDGTKTGVFEDDSLKNVAHSG 240 K H V VR N G + A+ DGT I ++ +G F + Sbjct: 171 KGVLVKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRT----- 225 Query: 241 SVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQAL--- 297 S+ + WSPDG+K+A S T+ ++ V K + I + W+ Sbjct: 226 SIIDMRWSPDGSKLAVVSDKWTLHVFEVFNDAENKRHVLKDWINIKYFQSEWSICNFKLK 285 Query: 298 VSISANGFINFVNPELGSI 316 VS +N + G + Sbjct: 286 VSKGSNDCKIAWISDTGLV 304 Score = 44.9 bits (104), Expect = 9e-05, Method: Composition-based stats. Identities = 36/260 (13%), Positives = 80/260 (30%), Gaps = 24/260 (9%) Query: 324 NKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFT 383 + I + D L +ST S ++ I + G + Sbjct: 14 SNPIVDYEFNQDQSCLI------------VSTPKSFDIYNVHPLKRIMSQEMPDAGTIRM 61 Query: 384 VSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADG----DIAVAACYKHIAIYSH 439 + +++ V + V + ++ A D + V + I+I+ Sbjct: 62 LHRTNYIAFVSTKKELLHIWDDVKKQDITRVKLDAAVKDLFLSREFIVVSQGDVISIFKF 121 Query: 440 GKL-TEVPISYNSSCVALSNDKQFVAVGGQD-SKVHVYKLSGASVSEV----KTIVHPAE 493 G ++ V + V + ++HV +L + V H Sbjct: 122 GNPWNKITEDIKFGGVCEFANGLLVYSNEFNLGQIHVTRLQTDAEQVVGKGVLVKAHANP 181 Query: 494 ITSVAFSNNGAFLVATDQSRK-VIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLA 552 + V + G + Q + + N + T+ + + WSPD +LA Sbjct: 182 VKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSII-DMRWSPDGSKLA 240 Query: 553 TGSLDNSVIVWNMNKPSDHP 572 S ++ V+ + +++ Sbjct: 241 VVSDKWTLHVFEVFNDAENK 260 Score = 42.2 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 17/131 (12%), Positives = 48/131 (36%), Gaps = 9/131 (6%) Query: 50 TDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGN-VRIWDTTQTTHILKTTIPVFSGPVKD 108 + H++ + + + G A+ G +R++ T + + + + D Sbjct: 170 GKGVLVKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIID 229 Query: 109 ISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKP-----SRPFRI 163 + W + ++A V + +F+ + ++ +N F+ + ++ Sbjct: 230 MRWSPDGSKLAVVS-DKWTLHVFEVFNDAENKRHVL--KDWINIKYFQSEWSICNFKLKV 286 Query: 164 ISGSDDNTVAI 174 GS+D +A Sbjct: 287 SKGSNDCKIAW 297 Score = 33.3 bits (74), Expect = 0.36, Method: Composition-based stats. Identities = 16/91 (17%), Positives = 31/91 (34%), Gaps = 7/91 (7%) Query: 304 GFINFVNPELGSIDQVRYG-----HNKAITALSSSADGKTLFSADAEGH-INSWDISTGI 357 G I+ + + V G H + + + G + + +G I + G+ Sbjct: 154 GQIHVTRLQTDAEQVVGKGVLVKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGV 213 Query: 358 SNRVF-PDVHATMITGIKTTSKGDLFTVSWD 387 R F + T I ++ + G V D Sbjct: 214 LVREFRRGLDRTSIIDMRWSPDGSKLAVVSD 244 >5A9Q-0 nrPDB Length = 380 Score = 67.6 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 34/279 (12%), Positives = 80/279 (28%), Gaps = 30/279 (10%) Query: 74 CASGDVHGN---VRIW----------DTTQTTHILKTTIPVFSGPVKDISWDSESKRIAA 120 A+G + +W D G V D+ + + + +AA Sbjct: 32 FATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQERIVAA 91 Query: 121 VGEG-------RERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPS---RPFRIISGSDDN 170 G + + T+ TG S I++ +D Sbjct: 92 SSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVTVGEDG 151 Query: 171 TVAIFEGPPFKFKSTFGEHTKFV-HSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFE 229 + +F + T H+V + + + G + +++ + G Sbjct: 152 RINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEIL-TVNSIGQLKIWDFR---QQGNEP 207 Query: 230 DDSLKNVAHSGSVFGLTWSPDGTKI-ASASADKTIKIWNVATLKVEKTIPVGTRIEDQQL 288 L + + P+ + A+ D + IW+V + ++ E ++ Sbjct: 208 SQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEV 267 Query: 289 GIIWT-KQALVSISANGFINFVNPELGSIDQVRYGHNKA 326 + + L + S +G + + ++ H Sbjct: 268 HFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGG 306 Score = 66.4 bits (160), Expect = 4e-11, Method: Composition-based stats. Identities = 37/277 (13%), Positives = 88/277 (31%), Gaps = 23/277 (8%) Query: 338 TLFSADAEG---HINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVP 394 T + + +I+ W I + GD+ + + D ++V Sbjct: 31 TFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQERIVA 90 Query: 395 AGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNS-SC 453 A +G P +S +H SY+S C Sbjct: 91 ASSTG------CVTVFLHHPNNQTLS----------VNQQWTTAHYHTGPGSPSYSSAPC 134 Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSR 513 + + + G+D ++++++ + + +V F ++ + Sbjct: 135 TGVVCNNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRT-PEILTVNSIG 193 Query: 514 KVIPYSV-ANNFELAHTNSWTFHTAKVACVSWSPDN-VRLATGSLDNSVIVWNMNKPSDH 571 ++ + E + S T + CV P+ +ATG D + +W++ + + Sbjct: 194 QLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMP 253 Query: 572 PIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 ++K A N + + +D ++ W+ Sbjct: 254 VSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWD 290 Score = 58.7 bits (140), Expect = 7e-09, Method: Composition-based stats. Identities = 45/270 (16%), Positives = 90/270 (33%), Gaps = 34/270 (12%) Query: 110 SWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTG---QARAMNSVDFKPSRPFRIISG 166 SWD+E I+ G FG++ + L + + F RI++ Sbjct: 36 SWDNEENYISLWSIGD--FGNLDSDGGFEGDHQLLCDIRHHGDVMDLQF--FDQERIVAA 91 Query: 167 SDDNTVAIFEGPPFKFK-------STFGEHTKF-------VHSVRYNPDGSLFASTGGDG 212 S V +F P +T HT + + G DG Sbjct: 92 SSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVTVGEDG 151 Query: 213 TIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLK 272 I L+ ++ S ++ +T+ +I + ++ +KIW+ Sbjct: 152 RINLFRADHKEAVRTIDNAD------SSTLHAVTF-LRTPEILTVNSIGQLKIWDFRQQG 204 Query: 273 VEKT---IPVGTRIEDQQLGIIWTKQALV-SISANGFINFVNPELGSI-DQVRYGHNKAI 327 E + G R+ + +Q +V + +G ++ + G++ + H + Sbjct: 205 NEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEM 264 Query: 328 TALSSSADG-KTLFSADAEGHINSWDISTG 356 + + LF+ +G + WD ST Sbjct: 265 WEVHFHPSNPEHLFTCSEDGSLWHWDASTD 294 Score = 41.8 bits (96), Expect = 9e-04, Method: Composition-based stats. Identities = 12/74 (16%), Positives = 28/74 (37%), Gaps = 7/74 (9%) Query: 64 VAKTSPSGYYC-ASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSES-KRIAAV 121 P+ + A+G G + IWD Q T + + + ++ + + + + Sbjct: 222 CVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSL-LKAHEAEMWEVHFHPSNPEHLFTC 280 Query: 122 GEGRERFGHVFLFD 135 E G ++ +D Sbjct: 281 SED----GSLWHWD 290 Score = 34.5 bits (77), Expect = 0.15, Method: Composition-based stats. Identities = 25/189 (13%), Positives = 65/189 (34%), Gaps = 22/189 (11%) Query: 438 SHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVY----KLSGASVSEVKTIVH-PA 492 H L ++ + + D++ + V V+ SV++ T H Sbjct: 64 DHQLLCDIRHHGDVMDLQFF-DQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHT 122 Query: 493 EITSVAFSN--------NGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSW 544 S ++S+ N +V + ++ + + + + ++ + V++ Sbjct: 123 GPGSPSYSSAPCTGVVCNNPEIVTVGEDGRINLFRADHKEAVRTID--NADSSTLHAVTF 180 Query: 545 SPDNVRLATGSLDNSVIVWNMNKPSDHP--IIIKGAHAMS--SVNSVIWLNETTIVSAGQ 600 L S+ + +W+ + + P I+ + V+ + + + GQ Sbjct: 181 LRTPEILTVNSI-GQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHP-NQQHVVATGGQ 238 Query: 601 DSNIKFWNV 609 D + W+V Sbjct: 239 DGMLSIWDV 247 >6IYY-A nrPDB Length = 317 Score = 67.6 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 45/302 (14%), Positives = 101/302 (33%), Gaps = 38/302 (12%) Query: 68 SPSGYYCA-----------SGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESK 116 SP G + + R+++T K G V + Sbjct: 4 SPHGNGLLYAGFNQDHGCFACGMENGFRVYNTDPLKEKEKQEF--LEGGVGHVEMLFRCN 61 Query: 117 RIAAVGEGRERFGHVFLFDTGTSNGNLTGQ-ARAMNSVDFKPSRPFRIISGSDDNTVAIF 175 +A VG G+++ V ++D + + + + +V + D V + Sbjct: 62 YLALVGGGKKK---VMIWDDLKKKTVIEIEFSTEVKAVKLR-----------RDRIVVVL 107 Query: 176 EGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDG-----TKTGVFED 230 + F T H V YNP G + +++ + G E Sbjct: 108 DSMIKVFTFTHNPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEK 167 Query: 231 DSLKNVAHSGSVFGLTWSPDGTKIASASADKT-IKIWNVATLKVEKTIPVGTRIED-QQL 288 + AH G + + + GT+IA+AS T I+I++ ++ + + + G++ + + Sbjct: 168 PPVDIPAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCI 227 Query: 289 GIIWTKQALVSISANGFINFV---NPELGSIDQVRYGHNKAITALSSSADGKTLFSADAE 345 + S +G ++ +P+ + + + + + + A+ Sbjct: 228 NFNQDASLICVSSDHGTVHIFAAEDPKSKWSFSKFQVPSGSPCICAFGTEPNAVIAICAD 287 Query: 346 GH 347 G Sbjct: 288 GS 289 Score = 57.2 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 30/211 (14%), Positives = 64/211 (30%), Gaps = 22/211 (10%) Query: 399 GVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLT------EVPISYNSS 452 D K ++ AV D V I +++ E + Sbjct: 76 WDDLKKKTVIEIEFSTEVKAVKLRRDRIVVVLDSMIKVFTFTHNPHQLHVFETCYNPKGL 135 Query: 453 CVALSNDKQFVAV--GGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATD 510 CV N + G V + L+ V H ++ +A + G + Sbjct: 136 CVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEGVLSCIALNLQGTRIATAS 195 Query: 511 QSRK-VIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIV------- 562 + + + ++ + A + C++++ D + S +V + Sbjct: 196 EKGTLIRIFDTSSGHLIQELRR-GSQAANIYCINFNQDASLICVSSDHGTVHIFAAEDPK 254 Query: 563 --WNMNK---PSDHPIIIKGAHAMSSVNSVI 588 W+ +K PS P I ++V ++ Sbjct: 255 SKWSFSKFQVPSGSPCICAFGTEPNAVIAIC 285 >5TF2-A nrPDB Length = 407 Score = 66.4 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 31/231 (13%), Positives = 66/231 (28%), Gaps = 38/231 (16%) Query: 64 VAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGE 123 V + A+G G VR+W +L+ G ++D++ + K + + Sbjct: 177 VVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLE--FKAHEGEIEDLALGPDGKLVTVGRD 234 Query: 124 GRERFGH----VFLFDTGTSNGNLTGQARAMNSVDF--KPSRP--FRIISGS-DDNTVAI 174 + V + + + F P +P R+ + + Sbjct: 235 LKASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQ 294 Query: 175 --------FEGPPFKFKSTFG-EHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKT 225 ++G F T H V + + G+ G++ +Y Sbjct: 295 PPPCYLTAWDGSNFLPLRTKSCGHE-VVSCLDVSESGTFLGLGTVTGSVAIYIAFSLQCL 353 Query: 226 GVFEDDSLKNVAHSGSVFGLTWSP-----------DGTKIASASADKTIKI 265 + AH V + + P T + S + D ++ Sbjct: 354 YYVRE------AHGIVVTDVAFLPEKGRGPELLGSHETALFSVAVDSRCQL 398 Score = 64.1 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 37/237 (15%), Positives = 65/237 (27%), Gaps = 21/237 (8%) Query: 267 NVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKA 326 V L+ +T + + + L + +G++ H Sbjct: 158 RVENLQAVQT-DFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGE 216 Query: 327 ITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSW 386 I L+ DGK L + + + W +++ +H G +S + Sbjct: 217 IEDLALGPDGK-LVTVGRDLKASVW-----QKDQLVTQLHW-QENGPTFSSTPYRYQACR 269 Query: 387 DDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVP 446 + PAG P L DG + + S G Sbjct: 270 FGQVPDQPAGLRLFTVQIPHKRLRQPPPCYLTA-WDGSNFL-----PLRTKSCGHEV--- 320 Query: 447 ISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNG 503 SC+ +S F+ +G V +Y H +T VAF Sbjct: 321 ----VSCLDVSESGTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEK 373 Score = 63.7 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 32/227 (14%), Positives = 62/227 (27%), Gaps = 33/227 (14%) Query: 153 VDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDG 212 V F + +G D V +++ P + F H + + PDG + G D Sbjct: 178 VCFNHDNTL-LATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDL 235 Query: 213 TIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASA-SADKTIKIWNVATL 271 ++ V L W +G +S + + V Sbjct: 236 KASVWQK-------------------DQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQ 276 Query: 272 KVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALS 331 + + + +G NF+ S GH ++ L Sbjct: 277 PAGLRLFTVQIPHK----RLRQPPPCYLTAWDGS-NFLPLRTKSC-----GHE-VVSCLD 325 Query: 332 SSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSK 378 S G L G + + + + H ++T + + Sbjct: 326 VSESGTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPE 372 Score = 49.1 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 13/71 (18%), Positives = 25/71 (35%), Gaps = 4/71 (5%) Query: 497 VAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSL 556 V F+++ L V + V L + H ++ ++ PD + G Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKV---PSLEKVLEFKAHEGEIEDLALGPDGKLVTVG-R 233 Query: 557 DNSVIVWNMNK 567 D VW ++ Sbjct: 234 DLKASVWQKDQ 244 Score = 42.2 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 19/66 (28%), Positives = 30/66 (45%), Gaps = 3/66 (4%) Query: 542 VSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQD 601 V ++ DN LATG D V VW + PS ++ AH + + + +V+ G+D Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKV--PSLEKVLEFKAHE-GEIEDLALGPDGKLVTVGRD 234 Query: 602 SNIKFW 607 W Sbjct: 235 LKASVW 240 Score = 31.0 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 7/27 (25%), Positives = 15/27 (55%), Gaps = 1/27 (3%) Query: 585 NSVIWLNETTIV-SAGQDSNIKFWNVP 610 V + ++ T++ + G D ++ W VP Sbjct: 176 KVVCFNHDNTLLATGGTDGYVRVWKVP 202 >5WLC-LH nrPDB Length = 896 Score = 62.6 bits (150), Expect = 5e-10, Method: Composition-based stats. Identities = 72/574 (12%), Positives = 163/574 (28%), Gaps = 91/574 (15%) Query: 24 LGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNV 83 + G ++ + V ++ + + H S G Y SG + Sbjct: 262 MAIDNMGQQLAVGFASGVISIVSLADLQIRLLKWHIDSVLSLSFSHDGSYLLSGGWEKVM 321 Query: 84 RIWDTTQTTHILKTTIPVFSGPVKDISWDS----ESKRIAAVGEGRERFGHVFLF---DT 136 +W + +P +G + D I + E + FL Sbjct: 322 SLWQLETNSQQF---LPRLNGIIIDCQVLGPQGNYYSLILQMTENNSNSDYQFLLLNASD 378 Query: 137 GTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTF--GEHTKFVH 194 TS ++ G NS +P ++ + N++ K F Sbjct: 379 LTSKLSINGPLPVFNSTIKHIQQPISAMNTKNSNSITSLNHSKKKQSRKLIKSRRQDFTT 438 Query: 195 SVRYNPDGSLF----ASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAH----------SG 240 +V NP S + +++ + S N + Sbjct: 439 NVEINPINKNLYFPHISA-----VQIFDFYKNEQVNYQYLTSGVNNSMGKVRFELNLQDP 493 Query: 241 SVFGLTWSPDGTKIAS-----------ASADKT--IKIWNVATLKVEKTIPVG----TRI 283 + L ++ DG + + +S D T +K W + + I Sbjct: 494 IITDLKFTKDGQWMITYEIEYPPNDLLSSKDLTHILKFWTKNDNETNWNLKTKVINPHGI 553 Query: 284 EDQQLGIIWTK------QALVSISANGFINFVNPEL-------GSIDQVRYGHNKAITAL 330 I+ + Q ++ NG + F + + I + H +L Sbjct: 554 SVPITKILPSPRSVNNSQGCLTADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSL 613 Query: 331 SSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHL 390 + S DG +F + ++ ++ T FT+ + Sbjct: 614 AWSQDGSLIFHGFDDK------------LQILDFDTFKKFESLENTKTVSEFTLDSEIQT 661 Query: 391 KVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYN 450 + + + +++ N ++ + S D V YK+ + +L Sbjct: 662 VKLINDTNLIVATRTTLNAINLLRGQVINSFDLYPFVNGVYKNGHM---DRLITCDERTG 718 Query: 451 SSCVALSN---DKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLV 507 + + ++ D V S++ ++ ++ T H I+ + ++ + F+ Sbjct: 719 NIALVINQQLTDLDGVPTINYKSRIIIFDSDLSTKLGNFT--HHEYISWIGWNYDTDFIF 776 Query: 508 ATDQSRKVIPYSVANNFELAHTNSWTFHTAKVAC 541 + + + T T + +V Sbjct: 777 ----------LDIESTLGVVGTTVNTQLSDEVNN 800 Score = 59.5 bits (142), Expect = 4e-09, Method: Composition-based stats. Identities = 75/570 (13%), Positives = 163/570 (28%), Gaps = 76/570 (13%) Query: 66 KTSPSGYY-CASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEG 124 G Y + + + ++ Q+ + +++D K+ Sbjct: 144 VFHSEGNYRILTTFKDPSQKAHNSLQSYRLY------------ALTFDDAKKQFEVA--- 188 Query: 125 RERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPP--FKF 182 + H + +SNG L S + ++S DD+ F Sbjct: 189 HQAEWHNVILSNISSNGKLLAHMCKDVSTKDHEHKSISVVSLFDDSVNLSFPLGSILSSQ 248 Query: 183 KSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSV 242 + +T++V S+ + G A G I + + + H SV Sbjct: 249 TQSLSYNTRYVSSMAIDNMGQQLAVGFASGVISI--------VSLADLQIRLLKWHIDSV 300 Query: 243 FGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISA 302 L++S DG+ + S +K + +W + T ++ +P I + S+ Sbjct: 301 LSLSFSHDGSYLLSGGWEKVMSLWQLET-NSQQFLPRLNGIIIDCQVLGPQGNY-YSLIL 358 Query: 303 NGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVF 362 N + + + LS + S ++T SN + Sbjct: 359 QMTEN---NSNSDYQFLLLNASDLTSKLSINGPLPVFNSTIKHIQQPISAMNTKNSNSIT 415 Query: 363 PDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSAD 422 H+ K + ++++ P + + Sbjct: 416 SLNHSKKKQSRKLIKSRRQ---DFTTNVEINPINKNLYFPHISAVQIFDFYKNEQVNYQY 472 Query: 423 GDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAV-----------GGQDSK 471 V + + PI + + + D Q++ +D Sbjct: 473 LTSGVNNSMGKVR---FELNLQDPIITD---LKFTKDGQWMITYEIEYPPNDLLSSKDLT 526 Query: 472 --VHVY-KLSGASVSEVKTIV---H--PAEITSVAFSN----NGAFLVATDQSRKVIPYS 519 + + K + +KT V H IT + S N + D + + +S Sbjct: 527 HILKFWTKNDNETNWNLKTKVINPHGISVPITKILPSPRSVNNSQGCLTADNNGGLKFWS 586 Query: 520 V---ANNFELAHTNSWTF-HTAKVACVSWSPDNVRLATGSLDN-------SVIVWNMNKP 568 +N+ L + F H + ++WS D + G D + + + Sbjct: 587 FDSHESNWCLKKISLPNFNHFSNSVSLAWSQDGSLIFHGFDDKLQILDFDTFKKFESLEN 646 Query: 569 SDHPIIIKGAHAMSSVNSVIWLNETTIVSA 598 + + +V + + IV+ Sbjct: 647 TKTVSEFTLDSEIQTVKLI--NDTNLIVAT 674 Score = 49.9 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 63/468 (13%), Positives = 147/468 (31%), Gaps = 79/468 (16%) Query: 198 YNPDGSL-FASTGGDGTIVLYNGVDGTKTGVFEDDSLK---NVAHS---GSVFGLTWSPD 250 ++ +G+ +T D + +N + + D K VAH +V S + Sbjct: 145 FHSEGNYRILTTFKDPSQKAHNSLQSYRLYALTFDDAKKQFEVAHQAEWHNVILSNISSN 204 Query: 251 GTKIASASAD--------KTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISA 302 G +A D K+I + ++ V + P+G+ + Q + + + + S++ Sbjct: 205 GKLLAHMCKDVSTKDHEHKSISVVSLFDDSVNLSFPLGSILSSQTQSLSYNTRYVSSMAI 264 Query: 303 N------------GFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINS 350 + G I+ V+ I ++ H ++ +LS S DG L S E ++ Sbjct: 265 DNMGQQLAVGFASGVISIVSLADLQI-RLLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSL 323 Query: 351 WDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKL 410 W + T S + P ++ +I +G+ +++ + + + Sbjct: 324 WQLET-NSQQFLPRLNGIIIDCQVLGPQGNYYSLILQMT------ENNSNSDYQFLLLNA 376 Query: 411 SSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDS 470 S L+++ + + S + + ++ + QD Sbjct: 377 SDLTSKLSINGPLPVFNSTIKHIQQPISAMNTKNSNSITSLNHSKKKQSRKLIKSRRQDF 436 Query: 471 KVHVYKLSGASVSEVKTIVHPAEITSVAFSNNG----AFLVAT--DQSRKVIPYSVANNF 524 + +++ H + + F N +L + + KV Sbjct: 437 TT---NVEINPINKNLYFPHISAVQIFDFYKNEQVNYQYLTSGVNNSMGKVRF------- 486 Query: 525 ELAHTNSWTFHTAKVACVSWSPDNVRLAT-----------GSLDNS--VIVW-----NMN 566 + + ++ D + T S D + + W N Sbjct: 487 ------ELNLQDPIITDLKFTKDGQWMITYEIEYPPNDLLSSKDLTHILKFWTKNDNETN 540 Query: 567 KPSDHPIIIKGAHAMSSVNSVIWL----NETTIVSAGQDSNIKFWNVP 610 +I ++ + N ++A + +KFW+ Sbjct: 541 WNLKTKVINPHGISVPITKILPSPRSVNNSQGCLTADNNGGLKFWSFD 588 Score = 44.5 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 81/478 (16%), Positives = 150/478 (31%), Gaps = 68/478 (14%) Query: 50 TDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDI 109 + T+ + ++ + G A G G + I + + V + Sbjct: 247 SQTQSLSYNTRYVSSMAIDNMGQQLAVGFASGVISI---VSLADLQIRLLKWHIDSVLSL 303 Query: 110 SWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDD 169 S+ + + + G E+ ++ +T NS F P II D Sbjct: 304 SFSHDGSYLLS--GGWEKVMSLWQLET--------------NSQQFLPRLNGIII----D 343 Query: 170 NTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVL-----YNGVDGTK 224 V +G + E+ N D D T L + T Sbjct: 344 CQVLGPQGNYYSLILQMTENNS-------NSDYQFLLLNASDLTSKLSINGPLPVFNSTI 396 Query: 225 TGVFEDDSLKNVAHSGSVFGLTWS---PDGTKIASASADKTIKIWNVATLKVEKTIPVGT 281 + + S N +S S+ L S I S D T NV + K + Sbjct: 397 KHIQQPISAMNTKNSNSITSLNHSKKKQSRKLIKSRRQDFTT---NVEINPINKNLYFPH 453 Query: 282 RIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFS 341 Q +Q +G VN +G + + IT L + DG+ + + Sbjct: 454 ISAVQIFDFYKNEQVNYQYLTSG----VNNSMGKVRFELNLQDPIITDLKFTKDGQWMIT 509 Query: 342 ADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVD 401 ++I ++ + ++ +W+ KV+ G V Sbjct: 510 ---------YEIEYPPNDLLSSKDLTHILKFWTKNDNET----NWNLKTKVINPHGISVP 556 Query: 402 SSKAVANKLSSQPLGLAVSAD--GDIAVAACYKHIAIYSHGKLT--EVPISYNSSCVALS 457 +K + + S ++AD G + + H + + K++ NS +A S Sbjct: 557 ITKILPSPRSVNNSQGCLTADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSLAWS 616 Query: 458 NDKQFVAVGGQDS-KVHVYKL--SGASVSEVKTIVH---PAEITSVAFSNNGAFLVAT 509 D + G D ++ + S+ KT+ +EI +V N+ +VAT Sbjct: 617 QDGSLIFHGFDDKLQILDFDTFKKFESLENTKTVSEFTLDSEIQTVKLINDTNLIVAT 674 >5WLC-LW nrPDB Length = 554 Score = 59.5 bits (142), Expect = 4e-09, Method: Composition-based stats. Identities = 35/241 (14%), Positives = 72/241 (29%), Gaps = 16/241 (6%) Query: 97 TTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFK 156 T + ++ D V G + TG L +A ++ Sbjct: 182 TELHRLKQHIEARHLDFLPYHYLLVTAGETGWLKYHDVSTGQLVSELRTKAGPTMAMAQN 241 Query: 157 PSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVL 216 P + G + TV+++ + V+S+ + G A+TG D ++ + Sbjct: 242 PWNAVMHL-GHSNGTVSLWSPSMPEPLVKLLSARGPVNSIAIDRSGYYMATTGADRSMKI 300 Query: 217 YNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKT 276 ++ + + E SL ++ S G + + S + +W K Sbjct: 301 WDIRNFKQLHSVE--SLPTPG-----TNVSISDTG--LLALSRGPHVTLW-----KDALK 346 Query: 277 IPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVR-YGHNKAITALSSSAD 335 + ++ +G + N + + GH IT L Sbjct: 347 LSGDSKPCFGSMGGNPHRNTPYMSHLFAGNKVENLGFVPFEDLLGVGHQTGITNLIVPGA 406 Query: 336 G 336 G Sbjct: 407 G 407 Score = 49.5 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 33/266 (12%), Positives = 76/266 (28%), Gaps = 20/266 (7%) Query: 196 VRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIA 255 ++Y +G+ TG G + + G L HS + + + A Sbjct: 116 IKYAKNGTHLLITGRKGHVASMDWRKGQLRAEL---FLNETCHSAT-----YLQNEQYFA 167 Query: 256 SASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGS 315 A T I++ ++ + + IE + L + LV+ G++ + + G Sbjct: 168 VAQKKYTF-IYDHEGTELHR---LKQHIEARHLDFLPYHYLLVTAGETGWLKYHDVSTGQ 223 Query: 316 IDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKT 375 + A++ + + + G ++ W S + I Sbjct: 224 LVSELRTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSA-RGPVNSIAI 282 Query: 376 TSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIA 435 G + D + + + + S P + D + A + Sbjct: 283 DRSGYYMATTGADRSMKIWDIRNF-----KQLHSVESLPTPGTNVSISDTGLLALSRGPH 337 Query: 436 IYSHGKLTEVPISYNSSCVALSNDKQ 461 + ++ +S S Sbjct: 338 VTLWKDALKLS--GDSKPCFGSMGGN 361 Score = 47.6 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 32/176 (18%), Positives = 69/176 (39%), Gaps = 14/176 (7%) Query: 437 YSHGKLTEVPISYNSSC--VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEI 494 + G+L + N +C ++Q+ AV Q +Y G + +K + Sbjct: 139 WRKGQLR-AELFLNETCHSATYLQNEQYFAVA-QKKYTFIYDHEGTELHRLKQHIEARH- 195 Query: 495 TSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATG 554 + F LV ++ + + V+ ++ + T ++ +P N + G Sbjct: 196 --LDFLPYHYLLVTAGETGWLKYHDVSTGQLVSELRTKAGPT---MAMAQNPWNAVMHLG 250 Query: 555 SLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT-IVSAGQDSNIKFWNV 609 + +V +W+ PS ++K A VNS+ + + G D ++K W++ Sbjct: 251 HSNGTVSLWS---PSMPEPLVKLLSARGPVNSIAIDRSGYYMATTGADRSMKIWDI 303 Score = 47.6 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 32/262 (12%), Positives = 76/262 (29%), Gaps = 20/262 (7%) Query: 352 DISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLS 411 D+ST + L H+ A L+ Sbjct: 96 DVSTANKALDLSLKEFGPYHIKYAKNGTHLLITGRKGHV----ASMDWRKGQLRAELFLN 151 Query: 412 SQPLGLAVSADGDIAVAACYKHIAIYSHG--KLTEVPISYNSSCVALSNDKQFVAVGGQD 469 + A K+ IY H +L + + + + G+ Sbjct: 152 ETCHSATYLQNEQYFAVAQKKYTFIYDHEGTELHRLKQHIEARHLDFLPYHYLLVTAGET 211 Query: 470 SKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHT 529 + + +S + ++A + A + + V +S + L Sbjct: 212 GWLKYHDVSTGQLVSELRTK-AGPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKL 270 Query: 530 NSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSV---NS 586 S V ++ +AT D S+ +W++ K H++ S+ + Sbjct: 271 LSARG---PVNSIAIDRSGYYMATTGADRSMKIWDIRN-------FKQLHSVESLPTPGT 320 Query: 587 VIWLNETTIVSAGQDSNIKFWN 608 + +++T +++ + ++ W Sbjct: 321 NVSISDTGLLALSRGPHVTLWK 342 Score = 37.2 bits (84), Expect = 0.023, Method: Composition-based stats. Identities = 16/97 (16%), Positives = 29/97 (29%), Gaps = 1/97 (1%) Query: 15 RTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTD-TEIYTEHSHQTTVAKTSPSGYY 73 RT G + + P + + ++ S+ + SGYY Sbjct: 229 RTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSARGPVNSIAIDRSGYY 288 Query: 74 CASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDIS 110 A+ +++IWD + G IS Sbjct: 289 MATTGADRSMKIWDIRNFKQLHSVESLPTPGTNVSIS 325 >2I3T-A nrPDB Length = 341 Score = 59.1 bits (141), Expect = 5e-09, Method: Composition-based stats. Identities = 36/211 (17%), Positives = 69/211 (32%), Gaps = 28/211 (13%) Query: 74 CASGDVHGNVRIWDT--TQTTHILKTTIPVFSGPVKDISWDSE---SKRIAAVGEGRERF 128 + G + + D I + + VK+ + + S+ I + + ++ Sbjct: 115 LIAASWDGLIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQW 174 Query: 129 GHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAI--FEGPPFKFKST- 185 + L + +G + V P S D VA+ F+ + S+ Sbjct: 175 FRLPLCEDDNGTIEESGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSK 234 Query: 186 ---FGEH---------TKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSL 233 F H V+S+ ++P + G DG I +N K F + Sbjct: 235 RFAFRCHRLNLKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFN- 293 Query: 234 KNVAHSGSVFGLTWSPDGTKIASASADKTIK 264 SV + S + + A++D T K Sbjct: 294 -----EDSVVKIACSDN--ILCLATSDDTFK 317 Score = 56.0 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 47/345 (13%), Positives = 104/345 (30%), Gaps = 40/345 (11%) Query: 181 KFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSG 240 + ++ ++ P SL T DG++ +Y D L+++ + Sbjct: 2 QIVQIEQAPKDYISDIKIIPSKSLLLITSWDGSLTVY----KFDIQAKNVDLLQSLRYKH 57 Query: 241 SVFGLTWSPDGT-KIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVS 299 + + + +I + I ++ + + + L++ Sbjct: 58 PLLCCNFIDNTDLQIYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRICKYGDDKLIA 117 Query: 300 ISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISN 359 S +G I ++P + + A+ K L S + + + + T S Sbjct: 118 ASWDGLIEVIDPRN---------YGDGVIAV------KNLNSNNTKVKNKIFTMDTNSS- 161 Query: 360 RVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAV 419 +I G+ + +D + G Q Sbjct: 162 --------RLIVGMNNSQVQWFRLPLCEDDNGTIEESGLKYQIRDVALLP-KEQEGYACS 212 Query: 420 SADGDIAVAACYKHIAIYSHGK----------LTEVPISYNSSCVALSNDKQFVAVGGQD 469 S DG +AV Y+ K L + ++Y + + S +F+ G D Sbjct: 213 SIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTNLAYPVNSIEFSPRHKFLYTAGSD 272 Query: 470 SKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRK 514 + + L + + + +A S+N L +D + K Sbjct: 273 GIISCWNLQTRKKIKNFAKFNEDSVVKIACSDNILCLATSDDTFK 317 Score = 46.4 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 50/317 (15%), Positives = 101/317 (31%), Gaps = 37/317 (11%) Query: 277 IPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPE-----LGSIDQVRYGHNKAITALS 331 I + + II +K L+ S +G + + + + +RY H Sbjct: 6 IEQAPKDYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLRYKHPLLCCNFI 65 Query: 332 SSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITG-IKTTSKGDLFTVSWDDHL 390 + D + ++ +G I D+ S + + A + I L SWD + Sbjct: 66 DNTDLQ-IYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRICKYGDDKLIAASWDGLI 124 Query: 391 KVV--PAGGSGVDSSKAVANKLSSQPLGLAVSADGDIA-VAACYKHIAIY--------SH 439 +V+ G GV + K + + + + + + + Sbjct: 125 EVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDN 184 Query: 440 GKLTEVPISYNSSCVALSNDKQF-VAVGGQDSKVHV--YKLSGA------------SVSE 484 G + E + Y VAL +Q A D +V V + G Sbjct: 185 GTIEESGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLN 244 Query: 485 VKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSW 544 +K + S+ FS FL + +++ ++ N F+ V ++ Sbjct: 245 LKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIK--NFAKFNEDSVVKIAC 302 Query: 545 SPDNVRLATGSLDNSVI 561 S + L + D++ Sbjct: 303 S--DNILCLATSDDTFK 317 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 46/318 (14%), Positives = 92/318 (28%), Gaps = 34/318 (10%) Query: 315 SIDQVRYGHNKAITALSSSADGKTLFSADAEG--HINSWDISTGISNRVFPDVHATMITG 372 I Q+ I+ + L +G + +DI + + + + Sbjct: 2 QIVQIEQAPKDYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLRYKHPLLC 61 Query: 373 IKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSAD-GDIAVAACY 431 DL +++ G S +A+ N + LG+ GD + A Sbjct: 62 CNFIDNTDLQIYVGTVQGEILKVDLIGSPSFQALTN--NEANLGICRICKYGDDKLIAAS 119 Query: 432 KHIAIY-----SHGKLTEVPISYNSSCVA-----LSNDKQ--FVAVGGQDSKVHVYKLS- 478 I ++G + NS+ + D + VG +S+V ++L Sbjct: 120 WDGLIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPL 179 Query: 479 -GASVSEVKTIVHPAEITSVAFSNNGAFLVATDQ-SRKVIP-YSVANNFELAHTNSWTFH 535 ++ +I VA A +V + + + + F Sbjct: 180 CEDDNGTIEESGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFR 239 Query: 536 TA-----------KVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSV 584 V + +SP + L T D + WN+ K SV Sbjct: 240 CHRLNLKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNE--DSV 297 Query: 585 NSVIWLNETTIVSAGQDS 602 + + ++ D+ Sbjct: 298 VKIACSDNILCLATSDDT 315 Score = 30.6 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 9/73 (12%), Positives = 19/73 (26%), Gaps = 2/73 (2%) Query: 61 QTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAA 120 + SP + + G + W+ I V I+ S++ A Sbjct: 253 PVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKF-NEDSVVKIAC-SDNILCLA 310 Query: 121 VGEGRERFGHVFL 133 + + Sbjct: 311 TSDDTFKTNAAID 323 >3DW8-B nrPDB Length = 447 Score = 59.1 bits (141), Expect = 5e-09, Method: Composition-based stats. Identities = 60/452 (13%), Positives = 135/452 (29%), Gaps = 87/452 (19%) Query: 62 TTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILK---------TTIPVF---------- 102 + + + SG A+GD G V I+ Q I +T Sbjct: 31 ISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSL 90 Query: 103 --SGPVKDISWDSESK---RIAAVGEGRERFGHVFLFDTGTSNGNLTGQARA------MN 151 + I W + + + + + + D NL + + Sbjct: 91 EIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVT 150 Query: 152 SVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGD 211 ++ RP ++ E P + + HT ++S+ N D + S D Sbjct: 151 TLRVPVFRPMDLMV----------EASPRRIFAN--AHTYHINSISINSDYETYLSA-DD 197 Query: 212 GTIVLYNGV-DGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG-TKIASASADKTIKIWNVA 269 I L++ + + + + + P+ +S+ TI++ ++ Sbjct: 198 LRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMR 257 Query: 270 TLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITA 329 + + + + + SIS Sbjct: 258 ASALCDRHSKLFEEPEDPSNRSFFSEIISSIS---------------------------D 290 Query: 330 LSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDL----FTVS 385 + S G+ + + D + WD++ VH + + + + + D F Sbjct: 291 VKFSHSGRYMMTRDY-LSVKVWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECC 349 Query: 386 WDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEV 445 W+ VV G ++ + ++ + + + L S + + K + + GK + Sbjct: 350 WNGSDSVVMTGS--YNNFFRMFDRNTKRDITLEASRENNKP-RTVLKPRKVCASGKRKKD 406 Query: 446 PISYNS-------SCVALSNDKQFVAVGGQDS 470 IS +S A + +AV ++ Sbjct: 407 EISVDSLDFNKKILHTAWHPKENIIAVATTNN 438 Score = 51.0 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 65/431 (15%), Positives = 144/431 (33%), Gaps = 84/431 (19%) Query: 191 KFVHSVRYNPDGSLFASTGGDGTIVL----------------YNGVDGTKTGVFEDDSLK 234 + +V +N G L A+ G +V+ YN ++ E D LK Sbjct: 29 DIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLK 88 Query: 235 NVAHSGSVFGLTWSP--DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW 292 ++ + + W P + + ++ DKTIK+W ++ P G ++ ++ G Sbjct: 89 SLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKR---PEGYNLK-EEDGRYR 144 Query: 293 TKQALVSISANGFINFVNPELGSIDQVRY-GHNKAITALSSSADGKTLFSADAEGHINSW 351 + ++ F S ++ H I ++S ++D +T SAD + IN W Sbjct: 145 DPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSAD-DLRINLW 203 Query: 352 DIS-TGISNRVF----------------PDVH-ATMITGIKTTSKGDLFTVS------WD 387 + T S + + H + T + ++SKG + D Sbjct: 204 HLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCD 263 Query: 388 DHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGK------ 441 H K+ S+++ +++ S + S G + Y + ++ Sbjct: 264 RHSKLFEEPED--PSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKVWDLNMENRPVE 321 Query: 442 --------LTEVPISYNSSCV------ALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKT 487 +++ Y + C+ + V G ++ ++ + ++ Sbjct: 322 TYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEA 381 Query: 488 IVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPD 547 + +V + A+ + +S F+ K+ +W P Sbjct: 382 SRENNKPRTV-LKP--RKVCASG----------KRKKDEISVDSLDFNK-KILHTAWHPK 427 Query: 548 NVRLATGSLDN 558 +A + +N Sbjct: 428 ENIIAVATTNN 438 Score = 36.0 bits (81), Expect = 0.052, Method: Composition-based stats. Identities = 16/132 (12%), Positives = 47/132 (35%), Gaps = 23/132 (17%) Query: 463 VAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVAN 522 +A G + + + S + + I++V F+++G L D+ +V+ + Sbjct: 1 MAGAGGGNDIQ-WCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQ 59 Query: 523 NFELAHTNS--------WTFHTAK------------VACVSWSP--DNVRLATGSLDNSV 560 ++ + + H + + + W P + + + D ++ Sbjct: 60 ENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTI 119 Query: 561 IVWNMNKPSDHP 572 +W +++ P Sbjct: 120 KLWKISERDKRP 131 Score = 31.8 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 16/105 (15%), Positives = 33/105 (31%), Gaps = 9/105 (8%) Query: 6 QTALFPSLPRTARGTAVVLGNTPAG-------DKIQYCNGTSVYTVPVGSLTDTEIYTEH 58 T + + + ++ G C+ S ++ ++E Sbjct: 225 LTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEI 284 Query: 59 SHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFS 103 + K S SG Y + D +V++WD ++ T V Sbjct: 285 ISSISDVKFSHSGRYMMTRDY-LSVKVWDLNMENRPVE-TYQVHE 327 >4NOX-A nrPDB Length = 746 Score = 57.6 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 66/487 (13%), Positives = 126/487 (25%), Gaps = 65/487 (13%) Query: 126 ERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKST 185 + G + + + Q V + P + + S V ++ G + Sbjct: 177 DTVGVFWNNEKDQPENIVDRQHWTETFVQWSPLGTY-LTSVHAQG-VQLWGGASWSRLRR 234 Query: 186 FGEHTKFVHSVRYNPDGSLFASTG-----------------GDGT-IVLYNGVDGTKTGV 227 F FV+ V ++P + DG ++++ Sbjct: 235 FPH--PFVNLVAFSPGEKYLVTWSNRPIQIPDSGHPVLTLDDDGKNYIIWDIETARPLRS 292 Query: 228 FEDDSLKNVAH-------SGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVG 280 F + H WS D +A + +I I+ + + + V Sbjct: 293 FAQQDIHPEEHGPKKGPPKFPWPVFKWSADDKYVARLNQGTSISIYELPKMNLLDKQAVK 352 Query: 281 TRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLF 340 T Q + F PE+G+ + ++ S +TL Sbjct: 353 IEGVMDFEWAPATVQREGVKTYEQLFCFWTPEIGNNPA-----RVGLMSIPSKQIVRTLN 407 Query: 341 SADAEGHINSWDISTGISNRVFPDVHATMITGIK-----TTSKGDLFTVSWDDHLKVVPA 395 W S G V D H+ K V D +K Sbjct: 408 LFSVSDVKMHWQ-SEGTYLCVKVDRHSKSKKSQATTLEIFRVKEKGVPVEVVDTIKDTVI 466 Query: 396 GGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAAC---YKHIAIYSHGKLTEVPISYNSS 452 + + +P+G C K + S L + N + Sbjct: 467 NFAWEPKGDRFVIITTPEPVGATAVPPKTSVSFFCPELKKGNQVGSFKHLRTLEKK-NHN 525 Query: 453 CVALSNDKQFVAVGG----QDSKVHVYKLS-----------GASVSEVKTIVHPAEITSV 497 + S +FV + Q S + + L A+ ++ IT V Sbjct: 526 AIYWSPKGRFVVIATVHNTQSSDLEFWDLDFDGEKPENEKDLAACLQLMGTGDHYGITDV 585 Query: 498 AFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVS---WSPDNVRLATG 554 + +G ++ +++ N + L + W P L T Sbjct: 586 EWDPSGRYVATWAS---AWKHTMENGYHLYDFKGELLREEHIEKFKQWQWRPRPPTLLTK 642 Query: 555 SLDNSVI 561 + Sbjct: 643 EEQKQIR 649 Score = 41.8 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 35/208 (16%), Positives = 71/208 (34%), Gaps = 12/208 (5%) Query: 294 KQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 + V + F N E + + + T + S G L S A+G + W Sbjct: 168 RDQFVMYRGDTVGVFWNNEKDQPENIVDRQHWTETFVQWSPLGTYLTSVHAQG-VQLWGG 226 Query: 354 STGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQ 413 ++ R FP ++ S G+ + V+W + +P G V + + Sbjct: 227 ASWSRLRRFPHPFVNLVAF----SPGEKYLVTWSNRPIQIPDSGHPV-----LTLDDDGK 277 Query: 414 PLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVH 473 + + + I HG + P + S D ++VA Q + + Sbjct: 278 NYIIWDIETARPLRSFAQQDIHPEEHGP-KKGPPKFPWPVFKWSADDKYVARLNQGTSIS 336 Query: 474 VYKLSGASVSEVKTIVHPAEITSVAFSN 501 +Y+L ++ + K V + ++ Sbjct: 337 IYELPKMNLLD-KQAVKIEGVMDFEWAP 363 >6FYY-p nrPDB Length = 763 Score = 56.8 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 62/505 (12%), Positives = 141/505 (27%), Gaps = 89/505 (17%) Query: 170 NTVAIFEGPPFKFKSTFGEHTKF-VHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVF 228 T + + S + + VR++P G+ S G + + G + + F Sbjct: 209 KTSVFWNSMFNEEDSLVESRENWSTNYVRFSPKGTYLFSYHQQG-VTAWGGPNFDRLRRF 267 Query: 229 EDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTI-------------------KIWNVA 269 ++N + SP+ + + S + I IW++A Sbjct: 268 YHPDVRNS---------SVSPNEKYLVTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWDIA 318 Query: 270 TLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGS--IDQVRYGHNKAI 327 + + T PV + + W+ G V+ + + + I Sbjct: 319 SGLLMATFPVIKSPYLKWPLVRWSYNDKYCARMVGDSLIVHDATKNFMPLEAKALKPSGI 378 Query: 328 TALSSSADGKTL--FSADAEGHINS--WDIST--GISNRVFPDVHATMITGIKTTSKGDL 381 S + +G L F E + W T +V + + Sbjct: 379 RDFSFAPEGVKLQPFRNGDEPSVLLAYWTPETNNSACTATIAEVPRGRVLKTVNLVQVSN 438 Query: 382 FTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGK 441 T+ W + + + + K L + + DI V +++ G Sbjct: 439 VTLHWQNQAEFLCFNVERHTK----SGKTQFSNLQICRLTERDIPVEKVELKDSVFEFGW 494 Query: 442 LTEVPISYNSSCVALSN--DKQFVAVGGQDSKVHVYKLSGASVSEVK------TIVHPAE 493 P +++ D + + + Y ++V + Sbjct: 495 ---EPHGNRFVTISVHEVADMNYAIPA---NTIRFYAPETKEKTDVIKRWSLVKEIPKTF 548 Query: 494 ITSVAFSNNGAFLVATD--------QSRKVIPYSVANNFELAHTNSWTFHTAKV------ 539 +V++S G F+V + + N + V Sbjct: 549 ANTVSWSPAGRFVVVGALVGPNMRRSDLQFYDMDYPGEKNINDNNDVSASLKDVAHPTYS 608 Query: 540 --ACVSWSPDNVRLA--TGSLDNSV----IVWNMNKPSDHPIIIKGAHAMSSVNSVIWLN 591 ++W P + + SL + V ++N+ + ++ + W Sbjct: 609 AATNITWDPSGRYVTAWSSSLKHKVEHGYKIFNIAGN------LVKEDIIAGFKNFAWRP 662 Query: 592 ETTIVSAGQD-----SNIKFWNVPF 611 + + + N++ W+ F Sbjct: 663 RPASILSNAERKKVRKNLREWSAQF 687 >2VDU-B nrPDB Length = 450 Score = 56.4 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 35/223 (15%), Positives = 65/223 (29%), Gaps = 23/223 (10%) Query: 26 NTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPS-GYYCASGDVHGNVR 84 N K++ G S+ + + + A D ++ Sbjct: 69 NENENKKLKSNKGDSIKRTAAKVPSPGLGAPPIYSYIRNLRLTSDESRLIACADSDKSLL 128 Query: 85 IWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGR-----ERFGHVFLFDTGT- 138 ++D +T+ + F + I+ + ++FG V+ D + Sbjct: 129 VFDVDKTSKNVLKLRKRF-------CFSKRPNAISIAEDDTTVIIADKFGDVYSIDINSI 181 Query: 139 -----SNGNLTGQARAMNSVDFKPSRPFR--IISGSDDNTVAIFEGPPFKFK-STFGEHT 190 + + G + V II+ D + I P H Sbjct: 182 PEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHK 241 Query: 191 KFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSL 233 FV S+ L S GGD I ++ G F+ +SL Sbjct: 242 HFVSSIC-CGKDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNSL 283 Score = 54.9 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 37/264 (14%), Positives = 86/264 (32%), Gaps = 14/264 (5%) Query: 353 ISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSS 412 +++ + VF + +++ + F W D + + + + + Sbjct: 11 LTSRDGSLVFAIIKNCILSFKYQSPNHWEFAGKWSDDFDKIQESRNTTAKEQQGQSSENE 70 Query: 413 QPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSND-KQFVAVGGQDSK 471 S GD + + A L PI + L++D + +A D Sbjct: 71 NENKKLKSNKGD----SIKRTAAKVPSPGLGAPPIYSYIRNLRLTSDESRLIACADSDKS 126 Query: 472 VHVYKLSGASVSEVK---TIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAH 528 + V+ + S + +K +++ + + ++ D+ V + + E Sbjct: 127 LLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFGDVYSIDINSIPEEKF 186 Query: 529 TNSWT-FHTAKVACVSWSPD---NVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSV 584 T H + + V D + + T D + + + H V Sbjct: 187 TQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI-SHYPQCFIVDKWLFGH-KHFV 244 Query: 585 NSVIWLNETTIVSAGQDSNIKFWN 608 +S+ + ++SAG D I W+ Sbjct: 245 SSICCGKDYLLLSAGGDDKIFAWD 268 Score = 53.3 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 30/180 (16%), Positives = 68/180 (37%), Gaps = 12/180 (6%) Query: 191 KFVHSVRYNPDGSLFASTGG-DGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP 249 ++ ++R D S + D ++++++ +K K S ++ + Sbjct: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKN---VLKLRKRFCFSKRPNAISIAE 159 Query: 250 DGTKIASASADKTIKIWNVATLKVEKTIPV---GTRIEDQQLGIIWTK---QALVSISAN 303 D T + A + ++ ++ EK G + +I Q +++ + Sbjct: 160 DDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRD 219 Query: 304 GFINF-VNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVF 362 I P+ +D+ +GH ++++ D L SA + I +WD TG + F Sbjct: 220 EHIKISHYPQCFIVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWDWKTGKNLSTF 278 Score = 46.8 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 34/191 (17%), Positives = 54/191 (28%), Gaps = 30/191 (15%) Query: 104 GPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRI 163 ++++ S+ R+ A + + + T + L F RP I Sbjct: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLR------KRFCFSK-RPNAI 155 Query: 164 ISGSDDNTVAIFE------------GPPFKFKST-FGEHTKFVHSVRY--NPDG-SLFAS 207 DD TV I + P KF H + V + DG + Sbjct: 156 SIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIIT 215 Query: 208 TGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 + D I + + H V + D + SA D I W+ Sbjct: 216 SDRDEHIKI------SHYPQCFIVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWD 268 Query: 268 VATLKVEKTIP 278 T K T Sbjct: 269 WKTGKNLSTFD 279 Score = 42.9 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 23/205 (11%), Positives = 65/205 (31%), Gaps = 31/205 (15%) Query: 325 KAITALSSSAD-GKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFT 383 I L ++D + + AD++ + +D+ +++ + + + + + Sbjct: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDV--DKTSKNVLKLRKRF----CFSKRPNAIS 156 Query: 384 VSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLT 443 ++ DD ++ V S ++S P L Sbjct: 157 IAEDDTTVIIADKFGDVYSID-----INSIPEE------------------KFTQEPILG 193 Query: 444 EVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNG 503 V + + + S+ QF+ +D + + + + H ++S+ + Sbjct: 194 HVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKD- 252 Query: 504 AFLVATDQSRKVIPYSVANNFELAH 528 L++ K+ + L+ Sbjct: 253 YLLLSAGGDDKIFAWDWKTGKNLST 277 >6N8P-A nrPDB Length = 979 Score = 56.0 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 66/512 (12%), Positives = 141/512 (27%), Gaps = 67/512 (13%) Query: 10 FPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSP 69 FP P LG +P+ + + + + + ++ T P Sbjct: 20 FPHQPSA-------LGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLP 72 Query: 70 SGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFG 129 + ++ +W + +D S+ G Sbjct: 73 GQCQLVTLLDDNSLHLWSLKVKGGASELQ--------EDESFTLRGPP----GAAPSATQ 120 Query: 130 HVFLFDTGTSNGNLTG-QARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGE 188 + + G ++ + V R + S D V + + F Sbjct: 121 ITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSD-AVLQRLPEEARHRRVFE- 178 Query: 189 HTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW 247 V +++ +P D + G +V+++ F S + + W Sbjct: 179 ---MVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLS--------SQQLENIWW 227 Query: 248 SPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFIN 307 DG + S +D + W PV + + + A I Sbjct: 228 QRDGRLLVSCHSDGSYCQW-----------PVSSEAQQPEPLRSLVPYGPFPCKAITRIL 276 Query: 308 FVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIST---GISNRVFPD 364 ++ G + G S + S +G ++D ++ G + D Sbjct: 277 WLTTRQGLPFTIFQGGMPRA-----SYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEAD 331 Query: 365 VHATM--ITGIKTTSKGDLFTVSWDDHLK---VVPAGGSGVDSSKAVANKLSSQPLGLAV 419 AT + ++ +L + +P S S+ ++ +S+ PL L Sbjct: 332 PAATFDDPYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLW- 390 Query: 420 SADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSG 479 I A ++ + PI +S + + G +D V + SG Sbjct: 391 ---ERIIAAGSRQNAHFSTMEW----PIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDASG 443 Query: 480 ASVSEVKTIVHPAEITSVAFSNNGAFLVATDQ 511 + + + + N F + Sbjct: 444 VCLRLLYKLS-TVRVFLTDTDPNENFSAQGED 474 Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 38/302 (12%), Positives = 88/302 (29%), Gaps = 58/302 (19%) Query: 272 KVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALS 331 + KT+ G + LG + + L + +G I G + N A+T + Sbjct: 11 QFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYG-APGVEFMGLHQENNAVTQIH 69 Query: 332 SSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLK 391 L + + ++ W + + + + G Sbjct: 70 LLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRG------------------- 110 Query: 392 VVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNS 451 P G + + V SS L + G++ V ++P Sbjct: 111 --PPGAAPSATQITVVLPHSSCELLYLGTESGNVFVV---------------QLPAFRAL 153 Query: 452 SCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSN-NGAFLVATD 510 +S+D + + V+++ + ++ + ++ Sbjct: 154 EDRTISSDAVLQRLPEEARHRRVFEM----------------VEALQEHPRDPNQILIGY 197 Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 V+ + + + L H S + ++ + W D L + D S W ++ + Sbjct: 198 SRGLVVIWDLQGSRVLYHFLS----SQQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQ 253 Query: 571 HP 572 P Sbjct: 254 QP 255 Score = 38.7 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 58/403 (14%), Positives = 110/403 (27%), Gaps = 55/403 (13%) Query: 3 EFSQTALFPSLPRTARGTAVV-----LGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYT- 56 S A+ LP AR V L P + V +Y Sbjct: 157 TISSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHF 216 Query: 57 EHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTT---QTTHILKTTIPVFSGP---VKDIS 110 S Q G S G+ W + Q L++ +P P + I Sbjct: 217 LSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRIL 276 Query: 111 WDSESKRIA----------AVGEGRERFGHVFL-----FDTGTSNGNLTGQARAMNSVDF 155 W + + + A R + FD + T A + F Sbjct: 277 WLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATF 336 Query: 156 KPSRPFRIISGSDDNTVAI------FEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTG 209 P+ ++ +++ V I + PP + H + + S Sbjct: 337 --DDPYALVVLAEEELVVIDLQTAGW--PPVQLPYLASLHCSAITC---SHHVSNI---- 385 Query: 210 GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVA 269 + L+ + + S G P + + D T++ W+ A Sbjct: 386 ---PLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWD-A 441 Query: 270 TLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNP--ELGSIDQVRYGHNKAI 327 + + + + + + + SA G P ++GS D I Sbjct: 442 SGVCLRLLYKLSTVRV----FLTDTDPNENFSAQGEDE-WPPLRKVGSFDPYSDDPRLGI 496 Query: 328 TALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMI 370 + L A G + +++ + + V A ++ Sbjct: 497 QKIFLCKYSGYLAVAGTAGQVLVLELNDEAAEQAVEQVEADLL 539 Score = 38.3 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 28/197 (14%), Positives = 64/197 (32%), Gaps = 13/197 (6%) Query: 151 NSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGG 210 S+ P + +++G +D TV ++ + + T V +P+ + A Sbjct: 415 TSLTPAPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTDPNENFSAQGED 474 Query: 211 DGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT 270 K G F+ S + + +A A + + + Sbjct: 475 -------EWPPLRKVGSFDPYSDDP---RLGIQKIFLCKYSGYLAVAGTAGQVLVLELND 524 Query: 271 LKVEKTIP-VGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITA 329 E+ + V + Q G W ++ + G + F P V+ +T+ Sbjct: 525 EAAEQAVEQVEADLLQDQEGYRWKGHERLAARS-GPVRF-EPGFQPFVLVQCQPPAVVTS 582 Query: 330 LSSSADGKTLFSADAEG 346 L+ ++ + + + G Sbjct: 583 LALHSEWRLVAFGTSHG 599 Score = 33.3 bits (74), Expect = 0.29, Method: Composition-based stats. Identities = 11/62 (17%), Positives = 23/62 (37%), Gaps = 2/62 (3%) Query: 328 TALSSSA-DGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSW 386 T+L+ + L + +G + WD S G+ R+ + + T + Sbjct: 415 TSLTPAPPQRDLLLTGHEDGTVRFWDAS-GVCLRLLYKLSTVRVFLTDTDPNENFSAQGE 473 Query: 387 DD 388 D+ Sbjct: 474 DE 475 >5AJA-A nrPDB Length = 361 Score = 55.6 bits (132), Expect = 6e-08, Method: Composition-based stats. Identities = 30/207 (14%), Positives = 59/207 (28%), Gaps = 27/207 (13%) Query: 45 PVGSLTDTEIYTEHSHQTTVAKTSPSGYYCA-SGDVHGNVR-IWDTTQTTHILKTTIPVF 102 V S + Y H+ T + S G S + +W + Sbjct: 65 NVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATWSQPLSALWGM---KSVFDMKHSFT 121 Query: 103 SGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARA----MNSVDFKPS 158 + S S+ + I G+ H++ TG L A N F P+ Sbjct: 122 EDHYVEFSKHSQDRVIGTKGD----IAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPT 177 Query: 159 RPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN 218 + +D +++ + F + + V ++P+G +++ Sbjct: 178 DDLVL----NDG--VLWDVRSAQAIHKFDKFNMNISGV-FHPNGLEVII-----NTEIWD 225 Query: 219 GVDGTKTGVFE--DDSLKNVAHSGSVF 243 D H+G+V Sbjct: 226 LRTFHLLHTVPALDQCRVVFNHTGTVM 252 Score = 54.5 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 38/270 (14%), Positives = 84/270 (31%), Gaps = 25/270 (9%) Query: 166 GSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKT 225 G D + P E ++ G + LYN G + Sbjct: 13 GCFDRHLIFSRFRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEE 72 Query: 226 GVFEDDSLKNVAHSGSVFGLTWSPDGTKIASAS--ADKTIKIWNVATLKVEKTIPVGTRI 283 + H+ ++ L S DG+ + +++ + +W + ++ K + Sbjct: 73 ASYN-------CHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVFDMK----HSFT 121 Query: 284 EDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGH----NKAITALSSSADGKTL 339 ED + Q V + + + + G+ + N + + + Sbjct: 122 EDHYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLV 181 Query: 340 FSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLF--TVSWDDHLKVVPAGG 397 +G WD+ + + F D I+G+ + ++ T WD + Sbjct: 182 L---NDGV--LWDVRSAQAIHKF-DKFNMNISGVFHPNGLEVIINTEIWDLRTFHLLHTV 235 Query: 398 SGVDSSKAVANKLSSQPLGLAVSADGDIAV 427 +D + V N + G + AD + + Sbjct: 236 PALDQCRVVFNHTGTVMYGAMLQADDEDDL 265 Score = 51.8 bits (122), Expect = 9e-07, Method: Composition-based stats. Identities = 23/222 (10%), Positives = 66/222 (29%), Gaps = 19/222 (8%) Query: 151 NSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGG 210 F F ++ G+ + ++ + ++++ H + + + DGSL ++ Sbjct: 41 TCCAFSARERFLML-GTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSAT 99 Query: 211 DGTIVLYNGVDGTKTGVFEDDSLKNVAHS-GSVFGLTWSPDGTKIASASADKTIKIWNVA 269 ++ + ++ S+ ++ HS + +S + I+++ Sbjct: 100 ------WSQP---LSALWGMKSVFDMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDIQ 150 Query: 270 TLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITA 329 T T+ + + + +G + N I+ Sbjct: 151 TGNKLLTLFNPDLANNYKRNCATFNPTDDLVLNDGV--LWDVRSAQAIHKFDKFNMNISG 208 Query: 330 LSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMIT 371 + +G + WD+ T P + + Sbjct: 209 V-FHPNGLEVIINTE-----IWDLRTFHLLHTVPALDQCRVV 244 Score = 46.8 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 25/211 (11%), Positives = 59/211 (27%), Gaps = 12/211 (5%) Query: 287 QLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSAD--A 344 ++ L+ + G + N G + HN AIT L S DG L ++ + Sbjct: 42 CCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATWS 101 Query: 345 EGHINSWDISTGISNR-VFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSS 403 + W + + + F + H + K + + T H+ + G + Sbjct: 102 QPLSALWGMKSVFDMKHSFTEDHY--VEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLF 159 Query: 404 KAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFV 463 + D + + S + + + + V Sbjct: 160 NPDLANNYKRNCATFNPTDDLVLNDGVLWDVR--SAQAIHKFDKFNMNISGVFHPNGLEV 217 Query: 464 AVGGQDSKVHVYKLSGASVSEVKTIVHPAEI 494 + + ++ L + + + Sbjct: 218 IINTE-----IWDLRTFHLLHTVPALDQCRV 243 Score = 40.2 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 24/155 (15%), Positives = 61/155 (39%), Gaps = 14/155 (9%) Query: 428 AACYKHIAIYSHGKLTEVPISYN-----SSCVALSNDKQFVAVGGQDSKVHVYKLSGASV 482 C+ I+S + V N +C A S ++F+ +G ++ +Y + Sbjct: 12 GGCFDRHLIFSRFRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQE 71 Query: 483 SEVKTIVHPAEITSVAFSNNGAFLV-ATDQSRKVI-PYSVANNFELAHTNSWTFHTAKVA 540 H + IT + S +G+ L+ + S+ + + + + F++ H+ + H Sbjct: 72 EASYN-CHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVFDMKHSFT-EDHY---- 125 Query: 541 CVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIII 575 V +S + G+ + ++++ + + Sbjct: 126 -VEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLF 159 >5WLC-LL nrPDB Length = 643 Score = 54.5 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 41/231 (17%), Positives = 78/231 (33%), Gaps = 33/231 (14%) Query: 49 LTDTEIYTEHSH-QTTVAKT----SPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFS 103 + +Y E S + T K S G +G + ++ K T S Sbjct: 46 WNENFLYLEDSKLKVTCLKWVNLASSDTVAIILGMNNGEIWLYSVLANEVTYKFTT-GNS 104 Query: 104 GPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKP------ 157 +KDI D ++ + + + FD L R N V Sbjct: 105 YEIKDI--DLMGNQLWCI----DSSDAFYQFD--LLQFKLLQHFRINNCVQLNKLTIVPA 156 Query: 158 -SRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTG-GDGTIV 215 +++ S +++++ + K TF H V +++ + F S GD + Sbjct: 157 GDSVAQLLVAS--HSISLIDIEEKKVVMTFPGHVSPVSTLQVITN-EFFISGAEGDRFLN 213 Query: 216 LYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIW 266 +Y+ G V +S + L+ S IA + D +++I+ Sbjct: 214 VYDIHSGMTKCVLVAES--------DIKELSHSGQADSIAVTTEDGSLEIF 256 Score = 34.8 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 31/195 (15%), Positives = 69/195 (35%), Gaps = 26/195 (13%) Query: 127 RFGHVFLFDTGTSNGNL---TGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFK 183 G ++L+ + TG + + +D ++ + I S F+ FK Sbjct: 81 NNGEIWLYSVLANEVTYKFTTGNSYEIKDIDLMGNQLWCIDSSDA---FYQFDLLQFKLL 137 Query: 184 STFGEHT-KFVHSVRYNPDGS-----LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 F + ++ + P G L AS +I L + + F Sbjct: 138 QHFRINNCVQLNKLTIVPAGDSVAQLLVAS----HSISLIDIEEKKVVMTFP-------G 186 Query: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQAL 297 H V L + I+ A D+ + ++++ + + + + I+ +L ++ Sbjct: 187 HVSPVSTLQVITNEFFISGAEGDRFLNVYDIHSGMTKCVLVAESDIK--ELSHSGQADSI 244 Query: 298 VSISANGFIN-FVNP 311 + +G + FV+P Sbjct: 245 AVTTEDGSLEIFVDP 259 Score = 30.2 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 26/244 (10%), Positives = 76/244 (31%), Gaps = 19/244 (7%) Query: 368 TMITGIKTTSKGDLFTVS--WDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDI 425 G++ T + V W+++ + V K V S + +G+I Sbjct: 26 KQRVGVQPTQRATSSGVDTVWNENFLYLEDSKLKVTCLKWVNLASSDTVAIILGMNNGEI 85 Query: 426 AVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEV 485 + + + Y SY + L ++ + + + L + + Sbjct: 86 WLYSVLANEVTYKF----TTGNSYEIKDIDLMGNQLWCIDSSDAF--YQFDLLQFKLLQH 139 Query: 486 KTIVHPAEITSVAFSNNGA---FLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACV 542 I + ++ + G L+ S +I ++ H + V+ + Sbjct: 140 FRINNCVQLNKLTIVPAGDSVAQLLVASHSISLIDIEEKKVVM-----TFPGHVSPVSTL 194 Query: 543 SWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDS 602 + ++ D + V++++ ++ + ++ + I +D Sbjct: 195 QVITNEFFISGAEGDRFLNVYDIHSG-MTKCVLVAESDIKELSHSGQADS--IAVTTEDG 251 Query: 603 NIKF 606 +++ Sbjct: 252 SLEI 255 >6CVZ-A nrPDB Length = 351 Score = 51.0 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 49/307 (15%), Positives = 97/307 (31%), Gaps = 35/307 (11%) Query: 230 DDSLKNVAHSGSVFGLTWSPD-GTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQL 288 S H + GL +S + SAS D TIK+ ++ T V +T G + Sbjct: 65 KSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNAGRPVW-SCC 123 Query: 289 GIIWTKQALVSISANGFINFVNPE-LGSIDQVRYGHNKAITALSSS----------ADGK 337 + + + ANG I + S Q +S S G Sbjct: 124 WCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAASAAFPYGG 183 Query: 338 TLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGG 397 L + W+ + H + ++ D T + H V Sbjct: 184 VLAGTLEDAS--FWE-------QKMDFSHWPHVLPLEPGGCIDFQTENSSRHCLVTYRPD 234 Query: 398 SGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALS 457 + ++V ++S D + +C + + + G ++ ++ N+ + Sbjct: 235 KNHTTIRSVLMEMS------YRLDDTGNPICSC-QPVHTFFGGPTCKL-LTKNAIFQSPE 286 Query: 458 NDKQFVAVGGQD--SKVHVYKLSGASVSEVKTIVHPAEITSVA-FSNNGAFLVATDQSRK 514 ND + G + + ++ + S+ + P + + F N +AT + Sbjct: 287 NDGNILVCTGDEAANSALLWDAASGSLLQDLQTDQP--VLDICPFEVNRNSYLATLTEKM 344 Query: 515 VIPYSVA 521 V Y Sbjct: 345 VHIYKWE 351 Score = 44.1 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 35/247 (14%), Positives = 71/247 (28%), Gaps = 36/247 (14%) Query: 146 QARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPD-GSL 204 + + + F ++S S DNT+ + T+ + V S + D + Sbjct: 73 HGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNA-GRPVWSCCWCLDEANY 131 Query: 205 FASTGGDGTIVLYNGVD-GTKTGVFEDDSLKNVAHS---GSVFGLTWSPDGTKIASASAD 260 + +G+I++Y+ + + + S P G +A D Sbjct: 132 IYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAASAAFPYGGVLAGTLED 191 Query: 261 KTIKIWN--VATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANG---FINFVNPEL-- 313 + W + +P+ ++ LV+ + I V E+ Sbjct: 192 AS--FWEQKMDFSHWPHVLPLEPGGCIDFQTENSSRHCLVTYRPDKNHTTIRSVLMEMSY 249 Query: 314 -----------GSIDQVRYGHNKAITALSSSA-------DGKTLFSADAE--GHINSWDI 353 +G L+ +A DG L E WD Sbjct: 250 RLDDTGNPICSCQPVHTFFG-GPTCKLLTKNAIFQSPENDGNILVCTGDEAANSALLWDA 308 Query: 354 STGISNR 360 ++G + Sbjct: 309 ASGSLLQ 315 Score = 32.5 bits (72), Expect = 0.54, Method: Composition-based stats. Identities = 35/310 (11%), Positives = 81/310 (26%), Gaps = 38/310 (12%) Query: 34 QYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPS-GYYCASGDVHGNVRIWDTTQTT 92 + G V + ++ ++ H Q S S + +++ T Sbjct: 49 SFLPGFGVKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNT 108 Query: 93 HILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNS 152 + PV W + G + +T + L Q Sbjct: 109 VVQTYNAGR---PVWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPL 165 Query: 153 VDFKP-------SRPFRIISGSDDNTVAIFE-------------GPPFKFKSTFGEHTKF 192 V + P+ + + +E P E++ Sbjct: 166 VSLSYMPRAASAAFPYGGVLAGTLEDASFWEQKMDFSHWPHVLPLEPGGCIDFQTENSSR 225 Query: 193 VHSVRYNPD--GSLFASTGGDGTIVLYNGVDGTK----TGVFEDDSLKNVAHSGSVFGLT 246 V Y PD + S + + L + + F + ++F Sbjct: 226 HCLVTYRPDKNHTTIRSVLMEMSYRLDDTGNPICSCQPVHTFFGGPTCKLLTKNAIFQ-- 283 Query: 247 WSP-DGTKIASASAD---KTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISA 302 SP + I + D + +W+ A+ + + + + D + + ++ Sbjct: 284 -SPENDGNILVCTGDEAANSALLWDAASGSLLQDLQTDQPVLD-ICPFEVNRNSYLATLT 341 Query: 303 NGFINFVNPE 312 ++ E Sbjct: 342 EKMVHIYKWE 351 >4U1F-A nrPDB Length = 497 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 61/470 (12%), Positives = 130/470 (27%), Gaps = 74/470 (15%) Query: 170 NTVAIFEGPPFKFKSTFGEHTKF-VHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVF 228 T + + S + + VR++P G+ S G + + G + + F Sbjct: 41 KTSVFWNSMFNEEDSLVESRENWSTNYVRFSPKGTYLFSYHQQG-VTAWGGPNFDRLRRF 99 Query: 229 EDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTI-------------------KIWNVA 269 ++N + SP+ + + S + I IW++A Sbjct: 100 YHPDVRNS---------SVSPNEKYLVTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWDIA 150 Query: 270 TLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGS--IDQVRYGHNKAI 327 + + T PV + + W+ G V+ + + + I Sbjct: 151 SGLLMATFPVIKSPYLKWPLVRWSYNDKYCARMVGDSLIVHDATKNFMPLEAKALKPSGI 210 Query: 328 TALSSSADGKTL--FSADAEGHINS--WDIST--GISNRVFPDVHATMITGIKTTSKGDL 381 S + +G L F E + W T +V + + Sbjct: 211 RDFSFAPEGVKLQPFRNGDEPSVLLAYWTPETNNSACTATIAEVPRGRVLKTVNLVQVSN 270 Query: 382 FTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGK 441 T+ W + + + + K L + + DI V +++ G Sbjct: 271 VTLHWQNQAEFLCFNVERHTK----SGKTQFSNLQICRLTERDIPVEKVELKDSVFEFGW 326 Query: 442 LTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVK------TIVHPAEIT 495 + + V D + + + Y ++V + Sbjct: 327 -EPHGNRFVTISVHEVADMNYAIPA---NTIRFYAPETKEKTDVIKRWSLVKEIPKTFAN 382 Query: 496 SVAFSNNGAFLVATD--------QSRKVIPYSVANNFELAHTNSWTFHTAKV-------- 539 +V++S G F+V + + N + V Sbjct: 383 TVSWSPAGRFVVVGALVGPNMRRSDLQFYDMDYPGEKNINDNNDVSASLKDVAHPTYSAA 442 Query: 540 ACVSWSPDNVRLA--TGSLDNSV----IVWNMNKPSDHPIIIKGAHAMSS 583 ++W P + + SL + V ++N+ II G + Sbjct: 443 TNITWDPSGRYVTAWSSSLKHKVEHGYKIFNIAGNLVKEDIIAGFKNFAW 492 >3WJ9-A nrPDB Length = 412 Score = 49.9 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 21/127 (16%), Positives = 49/127 (38%), Gaps = 14/127 (11%) Query: 103 SGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFR 162 GP+ D+ W+++SK V +FD + ++ N++ F P+ + Sbjct: 268 EGPIHDVCWNADSKEFGIVYG--YMPAKTAIFDNRANVVSIIP-PAPRNTLIFSPNSRYI 324 Query: 163 IISGSDD--NTVAIFEGPPF-KFKSTFGEHTKFVHSVRYNPDGSLFASTGG------DGT 213 +++G + ++ IF+ K +T ++PD + D + Sbjct: 325 LLAGFGNLQGSIDIFDAANNMKKITTVEA--ANCTYCEFSPDSQFLLTAVTSPRLRVDNS 382 Query: 214 IVLYNGV 220 I +++ Sbjct: 383 IKIWHIT 389 Score = 36.8 bits (83), Expect = 0.031, Method: Composition-based stats. Identities = 14/82 (17%), Positives = 31/82 (37%), Gaps = 17/82 (20%) Query: 194 HSVRYNPDGSLFASTGG---DGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD 250 +++ ++P+ G G+I +++ + K + + +SPD Sbjct: 313 NTLIFSPNSRYILLAGFGNLQGSIDIFDAANNMKKITTVEAANCT--------YCEFSPD 364 Query: 251 GTKIASASA------DKTIKIW 266 + +A D +IKIW Sbjct: 365 SQFLLTAVTSPRLRVDNSIKIW 386 >5K1H-B nrPDB Length = 576 Score = 48.3 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 50/372 (13%), Positives = 107/372 (28%), Gaps = 76/372 (20%) Query: 65 AKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVG-- 122 + SP G Y A+ + +W + I + G V+ I + + + Sbjct: 171 VRWSPKGTYLAT-FHQRGIALWGGEKFKQIQR---FSHQG-VQLIDFSPCERYLVTFSPL 225 Query: 123 -EGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDN---------TV 172 + ++ + ++D LTG + + S + I S D T+ Sbjct: 226 MDTQDDPQAIIIWD------ILTGHKK--RGFHCESSAHWPIFKWSHDGKFFARMTLDTL 277 Query: 173 AIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLY-----NGVDGTKTGV 227 +I+E P + ++P G++ A + + Sbjct: 278 SIYETPSMGLLDKKSLKISGIKDFSWSPGGNIIA---------FWVPEDKDIPARVTLMQ 328 Query: 228 FEDDSLKNVAHSGSVFGLT--WSPDGTKIASASADKTIK----------IWNVATLKVEK 275 V + +V W +G + D+T K I+ + +V Sbjct: 329 LPSRQEIRVRNLFNVVDCKLHWQKNGDYLC-VKVDRTPKGTQGVVTNFEIFRMREKQVPV 387 Query: 276 TIPVGTRIEDQQLGIIWTKQALVSISANG-----FINFVNPE-LGSIDQVRYGHNKAITA 329 + +++ + W +G ++F + + G I+ + + Sbjct: 388 DVV---EMKETIIAFAWEPNGSKFAVLHGEAPRISVSFYHVKSNGKIELSKMFDKQQANT 444 Query: 330 LSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFT--VSWD 387 + S G+ + A + + F D + I V WD Sbjct: 445 IFWSPQGQFVVLAG---------LRSMNGALAFVDTSDCTVMNI----AEHYMASDVEWD 491 Query: 388 DHLKVVPAGGSG 399 + V S Sbjct: 492 PTGRYVVTSVSW 503 Score = 40.2 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 58/461 (12%), Positives = 122/461 (26%), Gaps = 108/461 (23%) Query: 175 FEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLK 234 ++ P + + ++ D GD T + +N +D Sbjct: 110 WDIPEKQPFKDL-GNLRYWLEEAECRDQYSVIFESGDRTSIFWND--------VKDPVSI 160 Query: 235 NVAHSGSVFGLTWSPDGTKIAS-------------------------------------- 256 + + WSP GT +A+ Sbjct: 161 EERARWTETYVRWSPKGTYLATFHQRGIALWGGEKFKQIQRFSHQGVQLIDFSPCERYLV 220 Query: 257 ------ASAD--KTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINF 308 + D + I IW++ T ++ + + ++ + + Sbjct: 221 TFSPLMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFFARMTLDTLSIY 280 Query: 309 VNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW-----DISTGISNRVFP 363 P +G +D+ + I S S G + W DI ++ P Sbjct: 281 ETPSMGLLDK-KSLKISGIKDFSWSPGGNIIA---------FWVPEDKDIPARVTLMQLP 330 Query: 364 DVHATMITGIKT--------TSKGDLFTVSWDDHLKVVPAGGSG--------------VD 401 + + GD V D K + V Sbjct: 331 SRQEIRVRNLFNVVDCKLHWQKNGDYLCVKVDRTPKGTQGVVTNFEIFRMREKQVPVDVV 390 Query: 402 SSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGK--LTEVPISYNSSCVALSND 459 K + +P G + A + S+GK L+++ ++ + S Sbjct: 391 EMKETIIAFAWEPNGSKFAVLHGEAPRISVSFYHVKSNGKIELSKMFDKQQANTIFWSPQ 450 Query: 460 KQFVAV-GGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVA--TDQSRKV- 515 QFV + G + + + + + + H + V + G ++V + S KV Sbjct: 451 GQFVVLAGLRSMNGALAFVDTSDCTVMNIAEHYMA-SDVEWDPTGRYVVTSVSWWSHKVD 509 Query: 516 ---IPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLAT 553 ++ + + + W P L + Sbjct: 510 NAYWLWTFQGRL------LQKNNKDRFCQLLWRPRPPTLLS 544 Score = 34.5 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 24/164 (14%), Positives = 51/164 (31%), Gaps = 12/164 (7%) Query: 106 VKDISWDSESKRIAAVGEGRERFGHVFLF--DTGTSNGNLTGQARAMNSVDFKPSRPFRI 163 + +W+ + A + R F G + + N++ + P F + Sbjct: 396 IIAFAWEPNGSKFAVLHGEAPRISVSFYHVKSNGKIELSKMFDKQQANTIFWSPQGQFVV 455 Query: 164 ISG--SDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVD 221 ++G S + +A + EH V ++P G ++ + ++ Sbjct: 456 LAGLRSMNGALAFVDTSDCT-VMNIAEHYMA-SDVEWDPTGRYVVTS-----VSWWSHKV 508 Query: 222 GTKTGVFEDD-SLKNVAHSGSVFGLTWSPDGTKIASASADKTIK 264 ++ L + L W P + S K IK Sbjct: 509 DNAYWLWTFQGRLLQKNNKDRFCQLLWRPRPPTLLSQEQIKQIK 552 >5GRS-A nrPDB Length = 396 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 18/107 (16%), Positives = 40/107 (37%), Gaps = 7/107 (6%) Query: 188 EHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW 247 H + + + + FAS G D +V+++ V + + ++ + Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQM-----PRTLKAIAL 82 Query: 248 SPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK 294 P G ++ S D T+ I NV + + + + +L + W Sbjct: 83 DPQGNYVSLFSKD-TLFILNVESPSLMLQHSYHCKP-NSKLNVFWMP 127 Score = 35.6 bits (80), Expect = 0.058, Method: Composition-based stats. Identities = 49/374 (13%), Positives = 114/374 (30%), Gaps = 47/374 (12%) Query: 235 NVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK 294 V H + + S + AS D+ + +W++ K + ++ I Sbjct: 26 PVHHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQ-WCTKLVLSKEQMPRTLKAIALDP 84 Query: 295 QAL-VSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 Q VS+ + + +N E S+ H K + L+ W Sbjct: 85 QGNYVSLFSKDTLFILNVESPSLMLQHSYHCKPNSKLNV-----------------FWMP 127 Query: 354 STGISNRVFPDVHATMITGIKTTSKGDLFTVSWD-----DHLKVVPAGGSGVDSSKAVAN 408 T D + S G++ S + +V K+++ Sbjct: 128 GTHK------DDEWKNFELVVVESSGEIQVFSLTIEIEGADIALVEKFQLSSPIIKSISI 181 Query: 409 KLSSQPLGLAVSADGDIAV---AACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAV 465 + ++ G++ V I S K + +A++ D F+A Sbjct: 182 VSPTANRIACLTESGEVTVYSKKGPVWSPKILSQNKNYLTETKKDIYGIAMA-DILFLA- 239 Query: 466 GGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFE 525 +DS V + L + T+ P ++ + + + + V I + + Sbjct: 240 --RDSGVDMIDLKNDELLHSFTLP-PIKVNTFSVGVSNSRFVNGQFRVSSISFCFTHAVT 296 Query: 526 LAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVN 585 + + + + + D + +++ P + + +++ Sbjct: 297 EKVLYYYYGNES---------NESYIILNKWDQQPNLVDVHDPDNSLASLTFDELQENIH 347 Query: 586 SVIWLNETTIVSAG 599 V +E+ + S G Sbjct: 348 EVEDASESVMSSDG 361 >4YHC-A nrPDB Length = 468 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 18/107 (16%), Positives = 42/107 (39%), Gaps = 7/107 (6%) Query: 188 EHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW 247 H + + + + FAS G D ++V+++ V + + ++ + Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQM-----PRTLKAIAL 82 Query: 248 SPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK 294 P G ++ S D T+ I NV + + ++ + +L + W Sbjct: 83 DPQGNYVSLFSKD-TLFILNVESPSLMLQHSYHSKP-NSKLNVFWMP 127 Score = 36.4 bits (82), Expect = 0.041, Method: Composition-based stats. Identities = 49/374 (13%), Positives = 117/374 (31%), Gaps = 47/374 (12%) Query: 235 NVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK 294 V H + + S + AS D+++ +W++ K + ++ I Sbjct: 26 PVHHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQ-WCTKLVLSKEQMPRTLKAIALDP 84 Query: 295 QAL-VSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 Q VS+ + + +N E S+ H+K + L+ W Sbjct: 85 QGNYVSLFSKDTLFILNVESPSLMLQHSYHSKPNSKLNV-----------------FWMP 127 Query: 354 STGISNRVFPDVHATMITGIKTTSKGDLFTVSWD-----DHLKVVPAGGSGVDSSKAVAN 408 T D + S G++ S + +V K+++ Sbjct: 128 GTHK------DDEWKNFELVVVESSGEIQVFSLTIEIEGADIALVEKFQLSSPIIKSISI 181 Query: 409 KLSSQPLGLAVSADGDIAV---AACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAV 465 + +++ G++ V I S K + +A++ D F+A Sbjct: 182 VSPTANRIASLTESGEVTVYSKKGPVWSPKILSQNKNYLTETKKDIYGIAMA-DILFLA- 239 Query: 466 GGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFE 525 +DS V + L + T+ P ++ + + + + V I + + Sbjct: 240 --RDSGVDMIDLKNDELLHSFTLP-PIKVNTFSVGVSNSRFVNGQFRVSSISFCFTHAVT 296 Query: 526 LAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVN 585 + + + + + D + +++ P + + +++ Sbjct: 297 EKVLYYYYGNES---------NESYIILNKWDQQPNLVDVHDPDNSLASLTFDELQENIH 347 Query: 586 SVIWLNETTIVSAG 599 V +E+ + S G Sbjct: 348 EVEDASESVMSSDG 361 >5BPT-A nrPDB Length = 741 Score = 43.3 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 21/79 (26%), Positives = 38/79 (48%), Gaps = 1/79 (1%) Query: 491 PAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVR 550 P EI +A+S + +++ +V+ + +AN + +V C++W PD Sbjct: 13 PHEIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTGKEVTCLAWRPDGKI 72 Query: 551 LATGSLD-NSVIVWNMNKP 568 LA G D VI+ ++ KP Sbjct: 73 LAFGLADTKKVILCDVEKP 91 Score = 36.8 bits (83), Expect = 0.027, Method: Composition-based stats. Identities = 31/171 (18%), Positives = 57/171 (33%), Gaps = 15/171 (8%) Query: 191 KFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD 250 + + ++P L A G ++L+ + + + V L W PD Sbjct: 14 HEIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTG----KEVTCLAWRPD 69 Query: 251 GTKIASASAD-KTIKIWNVATLKVEKTIPVGTRIE-DQQLGIIWTKQALVSI-SANGFIN 307 G +A AD K + + +V + + + T I Q + + L S +A N Sbjct: 70 GKILAFGLADTKKVILCDVEKPESLHSFSLETPISCMQWMEVNVENSVLTSFYNAEDEAN 129 Query: 308 FVNPELGSIDQVRYG--------HNKAITALSSSADGKTLFSADAEGHINS 350 + P+L ++ + + I L A L G I Sbjct: 130 VLLPKLPALPKNYTATAKIFSEEKSDEILKLLGDARLNALVLGGDSGQIEI 180 Score = 35.6 bits (80), Expect = 0.065, Method: Composition-based stats. Identities = 12/76 (15%), Positives = 25/76 (32%), Gaps = 15/76 (19%) Query: 173 AIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGD-GTIVLYNGVDGTKTGVFEDD 231 ++ PP + K V + + PDG + A D ++L + F + Sbjct: 47 RVWSLPPNENTG------KEVTCLAWRPDGKILAFGLADTKKVILCDVEKPESLHSFSLE 100 Query: 232 SLKNVAHSGSVFGLTW 247 + + + W Sbjct: 101 T--------PISCMQW 108 Score = 35.2 bits (79), Expect = 0.093, Method: Composition-based stats. Identities = 17/94 (18%), Positives = 37/94 (39%), Gaps = 7/94 (7%) Query: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPA--EITSVAFSNNGAFLVAT-D 510 +A S + +A+ + +V +++L+ E+T +A+ +G L Sbjct: 19 LAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTGKEVTCLAWRPDGKILAFGLA 78 Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSW 544 ++KVI V L + ++C+ W Sbjct: 79 DTKKVILCDVEKPESLHSFSL----ETPISCMQW 108 Score = 33.3 bits (74), Expect = 0.31, Method: Composition-based stats. Identities = 12/82 (14%), Positives = 29/82 (35%), Gaps = 5/82 (6%) Query: 419 VSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQD-SKVHVYKL 477 V+ G++ + ++S +C+A D + +A G D KV + + Sbjct: 31 VNKAGEVLLHRLANIQRVWSLPPNENTGKE--VTCLAWRPDGKILAFGLADTKKVILCDV 88 Query: 478 SGASVSEVKTIVHPAEITSVAF 499 + + I+ + + Sbjct: 89 E--KPESLHSFSLETPISCMQW 108 >4FHN-A nrPDB Length = 394 Score = 42.9 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 27/119 (22%), Positives = 48/119 (40%), Gaps = 17/119 (14%) Query: 73 YCASGDVHGNVRIWDTTQTTHILKTTIPVFSGP---VKDIS----WDSESKR----IAAV 121 + A VR+ T T I + + SG V DI + ++++ IA+V Sbjct: 104 FLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVYSADNRLAEQVIASV 163 Query: 122 GEGRERFGHVFLFDTGTSNGNLTGQ--ARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP 178 G+ + ++ L G + SV F+PS P ++I G + + IF+ Sbjct: 164 GDD----CTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGERNGNIRIFDWT 218 Score = 41.8 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 42/275 (15%), Positives = 75/275 (27%), Gaps = 51/275 (18%) Query: 118 IAAVGEGRERFGHVFLFDTGTSNGNL---TGQARAMNSVDF-------KPSRPFRIISGS 167 +A V + + +T + L +G +N +D I S Sbjct: 105 LACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVYSADNRLAEQVIASVG 164 Query: 168 DDNTVAIFEGPP-FKFKSTFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGV----- 220 DD T+ I+ + + + + SV++ P + + +G I +++ Sbjct: 165 DDCTLIIWRLTDEGPILAGYPLSSPGI-SVQFRPSNPNQLIVGERNGNIRIFDWTLNLSA 223 Query: 221 ---------DGTKTGVFEDDSLKNVAHSGSVFG----LTW-SPDGTKIASASADKTIKIW 266 L N HS + + W DG+ I + W Sbjct: 224 EENSQTELVKNPWLLTLNTLPLVNTCHSSGIASSLANVRWIGSDGSGILAMCKSGAWLRW 283 Query: 267 NVATLKVEKTIPVGT------RIEDQQLGIIWTKQALVSI-------------SANGFIN 307 N+ I T + GI L + S +G I Sbjct: 284 NLFANNDYNEISDSTMKLGPKNLLPNVQGISLFPSLLGACPHPRYMDYFATAHSQHGLIQ 343 Query: 308 FVNPELGSIDQVRYGHNKAITALSSSADGKTLFSA 342 +N + + I DG L A Sbjct: 344 LINTYEKDSNSIPIQLGMPIVDFCWHQDGSHLAIA 378 Score = 39.5 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 20/114 (17%), Positives = 36/114 (31%), Gaps = 11/114 (9%) Query: 505 FLVATDQSRKVIPYSVANNFELAH--TNSWTFHTAKVACVS----WSPDNVR----LATG 554 FL Q V N + + H V + +S DN +A+ Sbjct: 104 FLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVYSADNRLAEQVIASV 163 Query: 555 SLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 D ++I+W + + SV IV ++ NI+ ++ Sbjct: 164 GDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIV-GERNGNIRIFD 216 Score = 33.7 bits (75), Expect = 0.26, Method: Composition-based stats. Identities = 20/117 (17%), Positives = 32/117 (27%), Gaps = 10/117 (8%) Query: 204 LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLT----WSPDGTK----IA 255 A D T+ L + +T + + H V + +S D IA Sbjct: 104 FLACVCQDNTVRL--IITKNETIITQHVLGGKSGHHNFVNDIDIADVYSADNRLAEQVIA 161 Query: 256 SASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPE 312 S D T+ IW + + L+ NG I + Sbjct: 162 SVGDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGERNGNIRIFDWT 218 >5WLC-LV nrPDB Length = 707 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 26/217 (11%), Positives = 65/217 (29%), Gaps = 25/217 (11%) Query: 151 NSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGG 210 N + + + +G+ + +++ K F HT +V + S Sbjct: 60 NKIKVSRDGQYCMATGTYKPQIHVYDFANLSLK--FDRHTDA-ENVDF-----TILSDDW 111 Query: 211 DGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSV----FGLTWSPDGTKIASASADKTIKIW 266 ++ L + + + ++ + L ++ + ++ + Sbjct: 112 TKSVHL------QNDRSIQFQNKGGLHYTTRIPKFGRSLVYNKVNCDLYVGASGNELYRL 165 Query: 267 NVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRY----- 321 N+ + + T + + I L + + + F +P S Y Sbjct: 166 NLEKGRFLNPFKLDTEGVNH-VSINEVNGLLAAGTETNVVEFWDPRSRSRVSKLYLENNI 224 Query: 322 -GHNKAITALSSSADGKTLFSADAEGHINSWDISTGI 357 +T S DG T + G+ +D+ T Sbjct: 225 DNRPFQVTTTSFRNDGLTFACGTSNGYSYIYDLRTSE 261 Score = 31.8 bits (70), Expect = 0.92, Method: Composition-based stats. Identities = 29/239 (12%), Positives = 78/239 (32%), Gaps = 19/239 (7%) Query: 294 KQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 + + + + I+ + S+ R+ + + S D + I + Sbjct: 69 QYCMATGTYKPQIHVYDFANLSLKFDRHTDAENVDFTILSDDWTKSVHLQNDRSIQFQNK 128 Query: 354 STGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSK---AVANKL 410 P +++ + S ++ ++ G ++ K N + Sbjct: 129 GGLHYTTRIPKFGRSLVYNK--VNCDLYVGASGNELYRLNLEKGRFLNPFKLDTEGVNHV 186 Query: 411 SSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYN-------SSCVALSNDKQFV 463 S + ++A + V + S +++++ + N + + ND Sbjct: 187 SINEVNGLLAAGTETNVVEFWDP---RSRSRVSKLYLENNIDNRPFQVTTTSFRNDGLTF 243 Query: 464 AVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNN---GAFLVATDQSRKVIPYS 519 A G + ++Y L + S +K + +I + + +N +V D+ R + Sbjct: 244 ACGTSNGYSYIYDLRTSEPSIIKDQGYGFDIKKIIWLDNVGTENKIVTCDK-RIAKIWD 301 >5CWW-B nrPDB Length = 595 Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 16/98 (16%), Positives = 33/98 (33%), Gaps = 16/98 (16%) Query: 178 PPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 P F + HT + + PD S + + K + +V Sbjct: 124 PNQDFLAVLTSHTVHICIL---PDSSHL---------HIQD-TTPFKPKFWTLGPTTHVT 170 Query: 238 HSGSVFGLTWSP---DGTKIASASADKTIKIWNVATLK 272 +V W P +G + + + D +++W ++T Sbjct: 171 SRSAVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTAD 208 Score = 32.5 bits (72), Expect = 0.50, Method: Composition-based stats. Identities = 30/170 (17%), Positives = 50/170 (29%), Gaps = 25/170 (14%) Query: 418 AVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKL 477 ++ G AC K I G L ++ S+ S S D Sbjct: 48 TIARRGTEIFVACGKQIR---WGDLAQLKESWESRPSRSSVGPTSTKKDSSDFD----DG 100 Query: 478 SGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFH-- 535 + + + +I + S N FL A S V + ++ L ++ F Sbjct: 101 AATAGYRIIKTPVADDIRQLVMSPNQDFL-AVLTSHTVHICILPDSSHLHIQDTTPFKPK 159 Query: 536 ------------TAKVACVSWSP---DNVRLATGSLDNSVIVWNMNKPSD 570 + V W P + L T + D V VW ++ Sbjct: 160 FWTLGPTTHVTSRSAVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTADR 209 >5TXC-A nrPDB Length = 705 Score = 41.0 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 29/152 (19%), Positives = 45/152 (29%), Gaps = 13/152 (8%) Query: 14 PRTARG--TAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSG 71 P T VV A D I G + S ++ T + SPSG Sbjct: 79 PVTNLNVFRMVVKATDGATDAIDVDVGGEYLFWTIPSWGYARNAPSGANLTIQPRWSPSG 138 Query: 72 YYCASGDVH-GNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGH 130 + A G VR+W + I ++D+ W ++ I + G Sbjct: 139 THLAYLRQDQGRVRVWRASVKGEGASPVIEDAYD-IEDVQWLDDNTLIYSGRPG------ 191 Query: 131 VFLFDTGTSNGNLTGQARAMNSVDFKPSRPFR 162 F + G+ + F P R Sbjct: 192 ---FVEAEAEIEREGRRGWVYDERFHPLTGAR 220 >3MUN-A nrPDB Length = 693 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 23/134 (17%), Positives = 47/134 (35%), Gaps = 14/134 (10%) Query: 215 VLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIA-----SASADKTIKIWNVA 269 VL+ +G VF D + + + ++ L++S DG +A + S + I + +V Sbjct: 104 VLWRQQEGKPAEVFLDPNTLSPDGTTALDQLSFSRDGRILAYSLSLAGSDWREIHLMDVE 163 Query: 270 TLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITA 329 + + +T + GI W S+ P+ + H Sbjct: 164 SKQPLETPLKDVKFS----GISWLGNEGFFYSSYD-----KPDGSELSARTDQHKVYFHR 214 Query: 330 LSSSADGKTLFSAD 343 L ++ + L Sbjct: 215 LGTAQEDDRLVFGA 228 >5BPW-A nrPDB Length = 843 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 19/95 (20%), Positives = 32/95 (33%), Gaps = 5/95 (5%) Query: 153 VDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHT---KFVHSVRYNPDGSLFASTG 209 + + P + I + V + F +F + K V + + PDG L A Sbjct: 26 LVWSP-KRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFAL 84 Query: 210 GD-GTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVF 243 D IVL + F ++ + H V Sbjct: 85 ADTKKIVLCDVEKPESLHSFSVEAPVSCMHWMEVT 119 Score = 38.7 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 22/107 (20%), Positives = 38/107 (35%), Gaps = 6/107 (5%) Query: 196 VRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIA 255 + ++P L A G ++L+ + F + V L W PDG +A Sbjct: 26 LVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTG----KEVTCLAWRPDGKLLA 81 Query: 256 SASAD-KTIKIWNVATLKVEKTIPVGTRIE-DQQLGIIWTKQALVSI 300 A AD K I + +V + + V + + + L S Sbjct: 82 FALADTKKIVLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSF 128 Score = 36.8 bits (83), Expect = 0.026, Method: Composition-based stats. Identities = 16/79 (20%), Positives = 35/79 (44%), Gaps = 1/79 (1%) Query: 491 PAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVR 550 P EI + +S + + + +V+ + +A+ + +V C++W PD Sbjct: 20 PQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKL 79 Query: 551 LATGSLD-NSVIVWNMNKP 568 LA D +++ ++ KP Sbjct: 80 LAFALADTKKIVLCDVEKP 98 Score = 34.8 bits (78), Expect = 0.099, Method: Composition-based stats. Identities = 9/78 (11%), Positives = 27/78 (34%), Gaps = 5/78 (6%) Query: 423 GDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQD-SKVHVYKLSGAS 481 G++ + ++S +C+A D + +A D K+ + + Sbjct: 42 GEVLLHRLASFHRVWSFPPNENTGKE--VTCLAWRPDGKLLAFALADTKKIVLCDVE--K 97 Query: 482 VSEVKTIVHPAEITSVAF 499 + + A ++ + + Sbjct: 98 PESLHSFSVEAPVSCMHW 115 >4IMM-A nrPDB Length = 399 Score = 38.3 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 54/356 (15%), Positives = 103/356 (28%), Gaps = 59/356 (16%) Query: 239 SGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALV 298 V L +P + +AS + + + ++I ED G V Sbjct: 69 RKDVIDLQIAPLADGMIAASRSGIV------SGYMGESIAWQYNAEDVITG-------GV 115 Query: 299 SISANGFINFVNPELGSIDQV--RYGHNKAITALSSSADGKTLFSADA------EGHINS 350 I G + + G + + R G + + L+SS+ L S D G I Sbjct: 116 GIDDQGSVAVIGTRSGKLIALDARTGAARWVVELASSSLAPALISGDKVIVITNSGTIFG 175 Query: 351 WDISTGISN-RVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANK 409 DI++G + + V T + G+ ++ D ++ + + + Sbjct: 176 LDINSGATVWQYATQVPNTSVRGMAKP-------LALDARTVLIGGADGRIHALDTMTGA 228 Query: 410 LSSQPLGLAVSADGDI-----------------AVAACYKHIAIYSHGKLTEVPISYNSS 452 G+I A+ +A + + +S SS Sbjct: 229 PVWTRRVGLAMGSGEIDQLRDIDGTPTVVDHYLYAASYSGQLAGFDMTTGRTMFVSELSS 288 Query: 453 CVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNN--GAFLVATD 510 L+ V D V + H + + + G ++ D Sbjct: 289 TKKLTTLADAVIGSSTDGDVVAFNRMTGEKL---WENHDLKYRGLT-NPVTIGTYIAVGD 344 Query: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMN 566 V + ++ N+ + ++ N RL S D V VW Sbjct: 345 ADGVVHILNHQGQI-ISRANT----KGALTNLTVI--NNRLYAQSADGVVTVWQFK 393 >6IGB-A nrPDB Length = 364 Score = 37.5 bits (85), Expect = 0.018, Method: Composition-based stats. Identities = 52/340 (15%), Positives = 105/340 (30%), Gaps = 47/340 (13%) Query: 236 VAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIP--VGTRIEDQQLGIIWT 293 VAH+ + LT++PD + + + + G + Q+ + Sbjct: 37 VAHTSNPSYLTFAPDQRTLFVVNENGRGGKGDTVGRATSYRFDPISGRLQQISQVQTLAD 96 Query: 294 KQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDI 353 S+S +G FV ++ L ADG + Sbjct: 97 HPTYSSLSHDGRYLFV-------ANYSVQPEGSVAVLPVRADGSL---------APVVQV 140 Query: 354 STGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKL--- 410 + +++V P + + + ++ G KV + + + + Sbjct: 141 ESHQASKVHPRQVSGHVHSVVSSPDGQYLFAPDLGADKVFVYRYAPEQAERPLQAADPAF 200 Query: 411 -----SSQPLGLAVSADGD--IAVAACYKHIAIYSH---GKLTEVPIS----------YN 450 S P L SADG + +++H G+L ++ Sbjct: 201 VPTPPGSGPRHLIFSADGRFAYLTLELSGQVMVFAHEGNGRLRQLQTHDLAPAGFQGKVG 260 Query: 451 SSCVALSNDKQFVAV--GGQDSKVHVYKLSGASVSEVKTIVHP---AEITSVAFSNNGAF 505 + + LS D +F+ V G D+++ + + AS E AFS G F Sbjct: 261 AGALHLSADGRFLGVLNRGDDNQLVTFAVDPASGQLRFVERRSVEGTEPREFAFSPGGRF 320 Query: 506 -LVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSW 544 LVA S ++ ++ + + + + Sbjct: 321 VLVANQNSDQLRVFARDPQSGQVGKTLQSVEVGSPSDLRF 360 >5OLJ-A nrPDB Length = 723 Score = 36.4 bits (82), Expect = 0.040, Method: Composition-based stats. Identities = 41/320 (12%), Positives = 96/320 (30%), Gaps = 43/320 (13%) Query: 249 PDGTKIASASADKTIKI-WNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFIN 307 PDG + ++T + +N A+ K T+ R + + VS + + + Sbjct: 49 PDGEHYTEMNRERTAIVRYNYASGKAVDTLFSIERAR--ECPFKQIQNYEVSSTGHHILL 106 Query: 308 FVNPEL----------------GSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 F + E ++ + H + + S DG+ + + +I Sbjct: 107 FTDMESIYRHSYRAAVYDYDVRRNLVKPLSEHVGKVMIPTFSPDGRMVAFV-RDNNIFIK 165 Query: 352 DISTGISNRVFPDVH-ATMITGIKTTSKGDLFTV----SWDDHLKVVPAGGSGVDSSKAV 406 +V D +++ G + F V SW + S + Sbjct: 166 KFDFDTEVQVTTDGQINSVLNGATDWVYEEEFGVTNLMSWSADNAFLAFVRSDESAVPEY 225 Query: 407 ANKL-------SSQPLGLAVSADGDIAVAACYKHIAIY-SHGKLTEVPISYNSSCVALSN 458 + + + + V+ ++A + + +A ++ Sbjct: 226 RMPMYEDKLYPEDYTYKYPKAGEKNSTVSLHLYNVADRNTKSVSLPIDADGYIPRIAFTD 285 Query: 459 DKQFVAVGGQD---SKVHVYKLSGASVSEV-------KTIVHPAEITSVAFSNNGAFLVA 508 + +AV + + +Y + S+ K V I ++ F+ G F Sbjct: 286 NADELAVMTLNRLQNDFKMYYVHPKSLVPKLILQDMNKRYVDSDWIQALKFTAGGGFAYV 345 Query: 509 TDQSRKVIPYSVANNFELAH 528 +++ Y N + Sbjct: 346 SEKDGFAHIYLYDNKGVMHR 365 Score = 35.6 bits (80), Expect = 0.071, Method: Composition-based stats. Identities = 21/110 (19%), Positives = 34/110 (30%), Gaps = 12/110 (10%) Query: 85 IWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDT-------G 137 ++D L + G V ++ + + +A V F F FDT G Sbjct: 122 VYD-YDVRRNLVKPLSEHVGKVMIPTFSPDGRMVAFV-RDNNIFIKKFDFDTEVQVTTDG 179 Query: 138 TSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFG 187 N L G + +F ++S S DN F + Sbjct: 180 QINSVLNGATDWVYEEEF---GVTNLMSWSADNAFLAFVRSDESAVPEYR 226 Score = 32.9 bits (73), Expect = 0.36, Method: Composition-based stats. Identities = 22/176 (12%), Positives = 51/176 (28%), Gaps = 20/176 (11%) Query: 445 VPISYNSSCVALSNDKQFVAVGGQDSKVHV-YKLSGASVSEVKTIVHPAE------ITSV 497 + D + ++ V Y + + + A I + Sbjct: 36 FYARSAGRGIRSMPDGEHYTEMNRERTAIVRYNYASGKAVDTLFSIERARECPFKQIQNY 95 Query: 498 AFSNNGAFLVATDQSRKVIPYSVAN-----NFELAHTNSWTFHTAKVACVSWSPDNVRLA 552 S+ G ++ + +S + + H KV ++SPD +A Sbjct: 96 EVSSTGHHILLFTDMESIYRHSYRAAVYDYDVRRNLVKPLSEHVGKVMIPTFSPDGRMVA 155 Query: 553 TGSLDNSVIVWNMNKPSDHPIIIKGA------HAMSSVNSVIWLNETTIVSAGQDS 602 DN++ + + ++ + G A V + ++S D+ Sbjct: 156 F-VRDNNIFIKKFDFDTEVQVTTDGQINSVLNGATDWVYEEEFGVTN-LMSWSADN 209 Score = 31.8 bits (70), Expect = 0.91, Method: Composition-based stats. Identities = 19/92 (20%), Positives = 34/92 (36%), Gaps = 11/92 (11%) Query: 181 KFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV--AH 238 EH V ++PDG + A D I + T+ V D + +V Sbjct: 130 NLVKPLSEHVGKVMIPTFSPDGRMVAFV-RDNNIFIKKFDFDTEVQVTTDGQINSVLNGA 188 Query: 239 SGSVFG--------LTWSPDGTKIASASADKT 262 + V+ ++WS D +A +D++ Sbjct: 189 TDWVYEEEFGVTNLMSWSADNAFLAFVRSDES 220 >6IGR-A nrPDB Length = 656 Score = 36.0 bits (81), Expect = 0.045, Method: Composition-based stats. Identities = 32/196 (16%), Positives = 55/196 (28%), Gaps = 20/196 (10%) Query: 66 KTSPSGYYCASGDVHGNVRI-WDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEG 124 + SP G A G V+ + F V W + + IA Sbjct: 85 RWSPDGQNLAFVRSAGEVKAALMLLPLKGGEARRVTHFKNGVSGPQWSPDGRFIAFTTTA 144 Query: 125 RERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKS 184 D LT N D+ P RP + +++ K + Sbjct: 145 DTEDKR----DERGEARVLTRPVYRANGADWLPERPAALW---------LYDVEADKLRE 191 Query: 185 TFGEHTKFVHSVRYNPD--GSLFASTGGDGTIVLYN---GVDGTKTGVFEDDSLKNVAHS 239 + + ++ + PD G L + + + T K + + Sbjct: 192 WY-APEIGIGALSWWPDSRGVLIVQSEDEWQASQWRQDVYDLPLPTADAPAAPQKLLDWN 250 Query: 240 GSVFGLTWSPDGTKIA 255 + GL PDG + A Sbjct: 251 SAAHGLAPHPDGQRFA 266 >1C5K-A nrPDB Length = 439 Score = 33.7 bits (75), Expect = 0.21, Method: Composition-based stats. Identities = 33/179 (18%), Positives = 66/179 (36%), Gaps = 25/179 (13%) Query: 191 KFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA----HSGSVFGLT 246 + + S ++PDGS A + +G + +++ VA H+G Sbjct: 201 QPLMSPAWSPDGSKLA------YVTFESGRSALVIQTLANGAVRQVASFPRHNG---APA 251 Query: 247 WSPDGTKIA-----SASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSIS 301 +SPDG+K+A + S + + ++A+ ++ + + G + ++ + Sbjct: 252 FSPDGSKLAFALSKTGSL--NLYVMDLASGQI-RQVTDGRSNNTEPTWFPDSQNLAFTSD 308 Query: 302 ANGFINFVNPE-LGSIDQVRYGHNKAITALSSSADGKTLFSADAEG---HINSWDISTG 356 G G Q S+DGK + + G HI D++TG Sbjct: 309 QAGRPQVYKVNINGGAPQRITWEGSQNQDADVSSDGKFMVMVSSNGGQQHIAKQDLATG 367 >4MHC-A nrPDB Length = 826 Score = 33.7 bits (75), Expect = 0.22, Method: Composition-based stats. Identities = 18/123 (14%), Positives = 38/123 (30%), Gaps = 20/123 (16%) Query: 258 SADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFV-------- 309 ++D + +WN+ I + + + VS S + Sbjct: 108 TSDNKLILWNINNSSEYHCIDEIEHTILKVKLVKPSPNTFVS-SVENLLIVATLFDIYIL 166 Query: 310 ----NPELGSIDQVRYGHNKAITALSSSA------DGKTLFSADAEGHINSWDISTGISN 359 N ++ G +T + S G+ F+ +G +N W++ S Sbjct: 167 TISFNDRTHELNIFNTGLKVNVTGFNVSNIISYERTGQIFFTGATDG-VNVWELQYNCSE 225 Query: 360 RVF 362 +F Sbjct: 226 NLF 228 Score = 31.8 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 13/42 (30%), Positives = 21/42 (50%) Query: 556 LDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVS 597 DN +I+WN+N S++ I + H + V V T + S Sbjct: 109 SDNKLILWNINNSSEYHCIDEIEHTILKVKLVKPSPNTFVSS 150 >3AZQ-A nrPDB Length = 662 Score = 33.7 bits (75), Expect = 0.23, Method: Composition-based stats. Identities = 29/170 (17%), Positives = 54/170 (31%), Gaps = 21/170 (12%) Query: 192 FVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV-----AHSGSVFGLT 246 FV R +PDG D + + G + V ED + ++ Sbjct: 189 FVTGPRLSPDGRQAVWLAWDHPRMPWEGTELKTARVTEDGRFADTRTLLGGPEEAIAQAE 248 Query: 247 WSPDGTKIASASADKTIKIWNV---------ATLKVEKTIPVGTRIEDQQL-GIIWTKQA 296 W+PDG+ I + D+T WN+ AT + + + Sbjct: 249 WAPDGSLIVA--TDRTGW-WNLHRVDPATGAATQLCRREEEFAGPLWTPGMRWFAPLANG 305 Query: 297 LVSISANG---FINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSAD 343 L+++ + ++PE G + + L+ S +A Sbjct: 306 LIAVVHGKGAAVLGILDPESGELVDAAGPWTEWAATLTVSGTRAVGVAAS 355 Score = 31.8 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 15/102 (14%), Positives = 30/102 (29%), Gaps = 13/102 (12%) Query: 478 SGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYS---------VANNFELAH 528 ++V E+ H +T S +G V +P+ + Sbjct: 175 DRSAVRELSDDAH-RFVTGPRLSPDGRQAVWLAWDHPRMPWEGTELKTARVTEDGRFADT 233 Query: 529 TNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 +A W+PD + D + WN+++ Sbjct: 234 RTLLGGPEEAIAQAEWAPDGSLIVAT--DRTGW-WNLHRVDP 272 >5WLC-LK nrPDB Length = 575 Score = 32.5 bits (72), Expect = 0.48, Method: Composition-based stats. Identities = 30/151 (19%), Positives = 48/151 (31%), Gaps = 13/151 (8%) Query: 203 SLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKT 262 + F + DG IV+Y+ D + + + + G I + DK Sbjct: 100 NFFVNGFPDGRIVVYSSNG--------KDIVNIIKNKKEILGADTDESDIWILDS--DKV 149 Query: 263 IKIWNVATLKVEKTIPVGTRIEDQQLGI---IWTKQALVSISANGFINFVNPELGSIDQV 319 +K K KT + +D+ + LV I + V+P Sbjct: 150 VKKLQYNNSKPLKTFTLVDGKDDEIVHFQILHQNGTLLVCIITKQMVYIVDPSKRRPSTK 209 Query: 320 RYGHNKAITALSSSADGKTLFSADAEGHINS 350 A S+DGK L A+ E I Sbjct: 210 YSFEISDAVACEFSSDGKYLLIANNEELIAY 240 >3R3L-A nrPDB Length = 582 Score = 31.0 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 21/132 (15%), Positives = 45/132 (34%), Gaps = 5/132 (3%) Query: 267 NVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVN-PELGSIDQVRYGHNK 325 + + + + + VGT D L + + L S + +G++ + + Sbjct: 79 ELKSTQQKSVLRVGTLSSDDLLTLAADLEKLKSKVTRTERPLSSGVYMGNLSSQQLDQRR 138 Query: 326 AITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVS 385 A+ L +G A +G + WD+ +T T +G V Sbjct: 139 ALLNLIGMTNGSQGSQAGRDGVVRVWDVKNAELLNNQFGT-MPSLTLACLTKQG---QVD 194 Query: 386 WDDHLKVVPAGG 397 +D ++ + G Sbjct: 195 LNDVVQALTDLG 206 >5SUM-A nrPDB Length = 468 Score = 31.0 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 18/93 (19%), Positives = 38/93 (40%), Gaps = 4/93 (4%) Query: 389 HLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPIS 448 ++V A G V SS + L + ++ D V + + GK+ I+ Sbjct: 310 QMEVFDAKGENVVSSLGNFQSETFNELNV-ITTDYKKNVFKFDGNGRML--GKVGRDDIT 366 Query: 449 YNSSCVALSNDKQFVAVGGQDSKVHVYKLSGAS 481 +S+ + + D +++ GG D V ++ + Sbjct: 367 GSSTYIHVH-DGKYLLQGGLDRYVRIFDIKTNK 398 >2ZZK-A nrPDB Length = 695 Score = 31.0 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 19/119 (15%), Positives = 45/119 (37%), Gaps = 13/119 (10%) Query: 454 VALSNDKQFVAVGGQDSKVH------VYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLV 507 +S + Q + +GG+ + ++ + S +K++ H S +G L+ Sbjct: 446 TTISRNNQLLLIGGRKAPHQGLSDNWIFDMKTREWSMIKSLSHTRFRHSACSLPDGNVLI 505 Query: 508 ATDQSR--KVIPYSVANN-FELAHTNSWTFHTAKVA-CVSW---SPDNVRLATGSLDNS 559 + ++ Y+V F+ F + V+ + + S + L G +D + Sbjct: 506 LGGVTEGPAMLLYNVTEEIFKDVTPKDEFFQNSLVSAGLEFDPVSKQGIILGGGFMDQT 564 >4R40-A nrPDB Length = 411 Score = 30.2 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 33/169 (19%), Positives = 57/169 (33%), Gaps = 14/169 (8%) Query: 230 DDSLKNVAHSGS--VFGLTWSPDGTKIASA---SADKTIKIWNVATLKVEKTIPVGTRIE 284 D + V H + WSPDG+KIA S + I +A + + Sbjct: 169 DGYNQFVVHRSPEPLMSPAWSPDGSKIAYVTFESGKSALVIQTLANGAIRQVASFPRHNG 228 Query: 285 DQQLGIIWTKQALVSISANGFINFV--NPELGSIDQVRYGHNKAITALSSSADGKTLFSA 342 TK ++S +G +N + G I QV G + T S D + L Sbjct: 229 APAFSPDGTK-LAFALSKSGSLNLYVMDLASGQISQVTDGRSNN-TEPSWFPDSQNLAYT 286 Query: 343 DAEG---HINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDD 388 +G + +I+ G+ R+ + + G + + Sbjct: 287 SDQGGRPQVYKVNINGGVPQRITWEGSQNQ--NADVSPDGKFLVLVSSN 333 >3V8H-A nrPDB Length = 327 Score = 29.8 bits (65), Expect = 3.1, Method: Composition-based stats. Identities = 10/51 (19%), Positives = 18/51 (35%), Gaps = 1/51 (1%) Query: 214 IVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD-GTKIASASADKTI 263 +++ + + G V+G+ W G K+ A AD I Sbjct: 81 CKVWDANANENAQWLANPYRRGADDLGDVYGVQWRRWPGYKVLDAHADAQI 131 >1Z68-A nrPDB Length = 719 Score = 29.5 bits (64), Expect = 4.3, Method: Composition-based stats. Identities = 27/152 (17%), Positives = 51/152 (33%), Gaps = 20/152 (13%) Query: 209 GGDGTIVLYNGVDGTKTGVFEDDSLKNV-----AHSGSVFGLTWSPDGTKIASASADKTI 263 D IVLYN G + + ++K+V S + D +K+ S T Sbjct: 33 SADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATY 92 Query: 264 KIWNVATLKVEKTIPVGTRIEDQQLGIIWTK------QALVSISANGFINFVNPELGSID 317 I++++ + + + I+ + +K + G F G + Sbjct: 93 YIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGREN 152 Query: 318 QVRYGHNKAI---------TALSSSADGKTLF 340 ++ G + AL S +GK L Sbjct: 153 KIFNGIPDWVYEEEMLATKYALWWSPNGKFLA 184 >2Z8G-A nrPDB Length = 549 Score = 28.7 bits (62), Expect = 7.3, Method: Composition-based stats. Identities = 9/55 (16%), Positives = 20/55 (36%), Gaps = 2/55 (3%) Query: 206 ASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASAD 260 AS + + ++ G G + F + + A + WS + + + D Sbjct: 273 ASGANNNGLRMWRGTLGNSSQTFVLNGVTVSA--PPFNSMDWSGNSLDLITCRVD 325 >4H0U-A nrPDB Length = 266 Score = 28.7 bits (62), Expect = 8.8, Method: Composition-based stats. Identities = 11/47 (23%), Positives = 18/47 (38%), Gaps = 1/47 (2%) Query: 518 YSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWN 564 + + F L T FH + V + W DN++ +WN Sbjct: 39 FDLNEGFPLLTTKKVHFH-SVVGELLWFLQGDSNVKWLQDNNIRIWN 84 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.117 0.297 Lambda K H 0.267 0.0358 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 20,679,739 Number of Sequences: 36641 Number of extensions: 756724 Number of successful extensions: 9207 Number of sequences better than 10.0: 173 Number of HSP's better than 10.0 without gapping: 240 Number of HSP's successfully gapped in prelim test: 78 Number of HSP's that attempted gapping in prelim test: 2144 Number of HSP's gapped (non-prelim): 2075 length of query: 611 length of database: 10,336,785 effective HSP length: 103 effective length of query: 508 effective length of database: 6,562,762 effective search space: 3333883096 effective search space used: 3333883096 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 62 (28.7 bits)