BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q09128 (514 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3K9V-A nrPDB 997 0.0 3MZS-A nrPDB 226 2e-59 3N9Z-A nrPDB 218 4e-57 4ZGX-A nrPDB 201 7e-52 6M7X-A nrPDB 200 1e-51 5VEU-A nrPDB 139 4e-33 6DA2-A nrPDB 128 5e-30 5YLW-A nrPDB 124 1e-28 6B82-A nrPDB 117 2e-26 6C94-A nrPDB 115 5e-26 2PG7-A nrPDB 111 8e-25 5UYS-A nrPDB 111 1e-24 4H1N-A nrPDB 108 5e-24 4R1Z-A nrPDB 107 1e-23 3E6I-A nrPDB 105 4e-23 4GQS-A nrPDB 99 4e-21 3IBD-A nrPDB 99 6e-21 6DWN-A nrPDB 99 6e-21 3MDV-A nrPDB 98 7e-21 2NNH-A nrPDB 97 1e-20 4R20-A nrPDB 96 3e-20 6IQ5-A nrPDB 96 3e-20 3QZ1-A nrPDB 96 4e-20 5VBU-A nrPDB 95 7e-20 2HI4-A nrPDB 95 8e-20 5W0C-A nrPDB 94 1e-19 3DL9-A nrPDB 94 1e-19 3EL3-A nrPDB 94 2e-19 3TBG-A nrPDB 91 9e-19 1N6B-A nrPDB 90 2e-18 6AYB-A nrPDB 89 6e-18 2VE3-A nrPDB 86 4e-17 5E58-A nrPDB 84 1e-16 3JUS-A nrPDB 83 2e-16 4KPA-A nrPDB 79 4e-15 5E0E-A nrPDB 77 1e-14 3S79-A nrPDB 77 2e-14 1WIY-A nrPDB 76 4e-14 2W0A-A nrPDB 74 1e-13 3L4D-A nrPDB 71 1e-12 5FSA-A nrPDB 70 2e-12 2X2N-A nrPDB 61 1e-09 2WX2-A nrPDB 61 1e-09 1F4U-A nrPDB 60 3e-09 6CR2-A nrPDB 58 1e-08 4WMZ-A nrPDB 58 1e-08 3SN5-A nrPDB 57 2e-08 4TRI-A nrPDB 57 2e-08 3NC3-A nrPDB 57 3e-08 5JLC-A nrPDB 55 8e-08 2WIO-A nrPDB 54 2e-07 4RM4-A nrPDB 52 6e-07 6HQW-A nrPDB 52 9e-07 5CJE-A nrPDB 50 2e-06 6DCD-A nrPDB 50 2e-06 4WPZ-A nrPDB 50 2e-06 3P3Z-A nrPDB 50 2e-06 3R9C-A nrPDB 49 4e-06 2IAG-A nrPDB 49 4e-06 3MGX-A nrPDB 49 5e-06 1Z8P-A nrPDB 49 6e-06 1GWI-A nrPDB 49 6e-06 2XKR-A nrPDB 49 8e-06 5OFQ-A nrPDB 48 9e-06 4Z5P-A nrPDB 47 1e-05 3RWL-A nrPDB 47 2e-05 6HQG-A nrPDB 47 2e-05 3B98-A nrPDB 47 2e-05 6A7J-A nrPDB 47 2e-05 5GWE-A nrPDB 46 3e-05 5XJN-A nrPDB 46 3e-05 2Y5N-A nrPDB 46 3e-05 5LIE-A nrPDB 46 4e-05 1UE8-A nrPDB 46 4e-05 2WM5-A nrPDB 45 5e-05 2VZM-A nrPDB 45 6e-05 5FYF-A nrPDB 45 7e-05 3TKT-A nrPDB 44 1e-04 1CPT-A nrPDB 44 1e-04 6A7I-A nrPDB 44 2e-04 5L1U-A nrPDB 44 2e-04 5Z9I-A nrPDB 43 3e-04 3WVS-A nrPDB 43 3e-04 5D3U-A nrPDB 43 4e-04 4YZR-A nrPDB 42 5e-04 5DQN-A nrPDB 42 7e-04 5L94-A nrPDB 41 0.001 4PWV-A nrPDB 41 0.001 4XE3-A nrPDB 41 0.001 4UBS-A nrPDB 40 0.002 6HQD-A nrPDB 40 0.002 5HH3-A nrPDB 40 0.003 6G5O-A nrPDB 39 0.004 3OFT-A nrPDB 39 0.004 5H1Z-A nrPDB 39 0.004 5HDI-A nrPDB 39 0.005 4YT3-A nrPDB 39 0.005 4JBT-A nrPDB 39 0.006 5XNT-A nrPDB 38 0.010 5FOI-A nrPDB 38 0.011 3EJB-B nrPDB 37 0.014 3IVY-A nrPDB 37 0.014 3A1L-A nrPDB 37 0.014 5OMS-A nrPDB 37 0.015 6FSH-A nrPDB 37 0.016 1ODO-A nrPDB 37 0.016 4TX3-A nrPDB 37 0.018 6G71-A nrPDB 37 0.021 6CVC-A nrPDB 37 0.024 5IT1-A nrPDB 36 0.039 2RFC-A nrPDB 36 0.040 2Z36-A nrPDB 35 0.059 3BUJ-A nrPDB 35 0.066 5XW2-A nrPDB 35 0.069 5HIW-A nrPDB 35 0.072 4FB2-A nrPDB 34 0.13 6FYJ-A nrPDB 34 0.14 5M0P-A nrPDB 34 0.17 3ABA-A nrPDB 34 0.18 3OO3-A nrPDB 33 0.24 6GK6-A nrPDB 33 0.25 2RCM-A nrPDB 33 0.29 2ZBZ-A nrPDB 33 0.34 5OCD-A nrPDB 33 0.36 2UUQ-A nrPDB 33 0.39 3TYW-A nrPDB 33 0.43 6B11-A nrPDB 33 0.43 1Q5D-A nrPDB 32 0.45 5EX6-C nrPDB 32 0.47 6GII-A nrPDB 32 0.55 5EX8-A nrPDB 32 0.62 2ZQJ-A nrPDB 32 0.84 1EHE-A nrPDB 32 0.84 5YHJ-A nrPDB 31 1.1 5VWS-A nrPDB 31 1.1 4G0L-A nrPDB 31 1.5 6F0B-A nrPDB 30 1.7 3DBM-A nrPDB 30 2.2 6J9S-A nrPDB 30 2.4 1VBH-A nrPDB 30 3.3 4I6M-A nrPDB 29 3.8 6GMF-A nrPDB 29 4.9 5Y1I-A nrPDB 29 6.0 6M7L-A nrPDB 29 6.1 2IJ7-A nrPDB 28 7.0 5YSW-A nrPDB 28 8.7 3EB7-A nrPDB 28 9.3 >3K9V-A nrPDB Length = 482 Score = 997 bits (2578), Expect = 0.0, Method: Compositional matrix adjust. Identities = 480/481 (99%), Positives = 480/481 (99%) Query: 34 ASRAPKEVPLCPLMTDGETRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKY 93 ASRAPKEVPLCPLMTDGETRNVT LPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKY Sbjct: 2 ASRAPKEVPLCPLMTDGETRNVTDLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKY 61 Query: 94 GQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQ 153 GQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQ Sbjct: 62 GQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQ 121 Query: 154 EWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFE 213 EWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFE Sbjct: 122 EWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFE 181 Query: 214 SICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTL 273 SICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTL Sbjct: 182 SICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTL 241 Query: 274 AWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTAN 333 AWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTAN Sbjct: 242 AWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTAN 301 Query: 334 SLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF 393 SLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF Sbjct: 302 SLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF 361 Query: 394 TTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHL 453 TTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHL Sbjct: 362 TTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHL 421 Query: 454 PFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRP 513 PFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRP Sbjct: 422 PFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRP 481 Query: 514 R 514 R Sbjct: 482 R 482 >3MZS-A nrPDB Length = 486 Score = 226 bits (577), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 142/473 (30%), Positives = 238/473 (50%), Gaps = 32/473 (6%) Query: 59 PGPTNWPLLGSLLEIFWK-GGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEA 117 PG W L FW+ G ++ H E +KYG I+R KLG+ +SV++ P + Sbjct: 16 PGDNGWLNLYH----FWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAH 71 Query: 118 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDK 177 L++ E ++P+R +I PW AY + + G++ + W++ R ++M P I Sbjct: 72 LFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIP 131 Query: 178 KINEVLADFLERMDELCDERGR---IPDLYSELNKWSFESICLVLYEKRFGLLQKETEEE 234 +N V DF+ + + ++G + D+ +L ++FESI V++ +R G+L++ E Sbjct: 132 LLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPE 191 Query: 235 ALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCID------N 288 A FI A+ M T ++ P EL++ TK W+ H AWDTIF + + Sbjct: 192 AQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLR 251 Query: 289 RLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQA 348 R + PG L + + + + +++ A +TE+ V TT+ +L W LY ++R+ Sbjct: 252 RKTEFRNYPG--ILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNV 309 Query: 349 QRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYA 408 Q L +EV + + ++ L+ +P LKA +KE++RL P R + VL +Y Sbjct: 310 QEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYL 369 Query: 409 LPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLA 468 +P T++ + +G F KF P RWL K+K + F +L FG G R C+GRR+A Sbjct: 370 IPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIA 429 Query: 469 ELQLHLALCWIIQKYDIVATDNEPVEMLHLG--------ILVPSRELPIAFRP 513 EL++ L L I++ + VEM H+G IL P + + + FRP Sbjct: 430 ELEMTLFLIHILENFK--------VEMQHIGDVDTIFNLILTPDKPIFLVFRP 474 >3N9Z-A nrPDB Length = 487 Score = 218 bits (556), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 142/464 (30%), Positives = 227/464 (48%), Gaps = 13/464 (2%) Query: 59 PGPTNWPLLGSLLEIFWK-GGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEA 117 PG W L FW+ G K H + +KYG I+R KLG+ +SV++ P + Sbjct: 14 PGDNGWLNLYH----FWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVAL 69 Query: 118 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDK 177 L+++E +P+R I PW AY + G+++ + W++ R A +++M P Sbjct: 70 LFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLP 129 Query: 178 KINEVLADFLERMDELCDERGR---IPDLYSELNKWSFESICLVLYEKRFGLLQKETEEE 234 ++ V DF+ + + G D+ +L +++FESI V++ +R G+L++ E Sbjct: 130 LLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPE 189 Query: 235 ALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYS 294 A FI AI M T M+ P +L + TK W+ H AWD IF N Sbjct: 190 AQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELR 249 Query: 295 QQPGA--DFLCDIYQ---QDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQ 349 Q+ D+ +Y+ +S +++ A VTE+ V+TT+ +L W LY ++RN + Q Sbjct: 250 QKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQ 309 Query: 350 RRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYAL 409 L EV + Q A L+ +P LKA +KE++RL P R L VL +Y + Sbjct: 310 DMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMI 369 Query: 410 PKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAE 469 P T++ + LG F D F P RWL K+K I F +L FG G R C+GRR+AE Sbjct: 370 PAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAE 429 Query: 470 LQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRP 513 L++ + L +++ + + V IL+P + + F P Sbjct: 430 LEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWP 473 >4ZGX-A nrPDB Length = 489 Score = 201 bits (510), Expect = 7e-52, Method: Compositional matrix adjust. Identities = 134/454 (29%), Positives = 225/454 (49%), Gaps = 16/454 (3%) Query: 70 LLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRL 129 LL+I+ + G + H + + ++ G IFR LG V + P +E L + +S HP R+ Sbjct: 29 LLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRM 88 Query: 130 EIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLER 189 ++PW AYR HR G+ +L G EW+ R ++ P + + ++ V DF + Sbjct: 89 ILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQA 148 Query: 190 MDE--LCDERGRIP-DLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMM 246 + + L + RG + D+ + ++ E+ L L+ +R GL+ +L F+ A++ M Sbjct: 149 LKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMF 208 Query: 247 STFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCID--------NRLQRYSQQPG 298 + ++M P L + ++ KVW+ H AWD IF+ CI NR Q Y+ Sbjct: 209 KSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYT---- 264 Query: 299 ADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQS 358 + ++ + LS + + A EL +V+TTA L+ L+ L+RNP Q+ L QE + Sbjct: 265 -GIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLA 323 Query: 359 VLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLN 418 + +P L+A LKE++RL P F R + VL Y +P GT++ + Sbjct: 324 AAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVF 383 Query: 419 TQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCW 478 LG + F ++ P+RWL F H+PFG G R C+GRRLAE ++ L L Sbjct: 384 LYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHH 443 Query: 479 IIQKYDIVATDNEPVEMLHLGILVPSRELPIAFR 512 +++ + + E ++M++ IL P + FR Sbjct: 444 VLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFR 477 >6M7X-A nrPDB Length = 484 Score = 200 bits (509), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 132/449 (29%), Positives = 219/449 (48%), Gaps = 6/449 (1%) Query: 70 LLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRL 129 LL+I+ + G + H + + ++ G IFR LG V + P +E L + +S HP R+ Sbjct: 29 LLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRM 88 Query: 130 EIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLER 189 ++PW AYR HR G+ +L G EW+ R +++ P + + ++ V DF + Sbjct: 89 SLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQA 148 Query: 190 MDE--LCDERGRIP-DLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMM 246 + + L + RG + D+ + ++ E+ L L+ +R GL+ +L F+ A++ M Sbjct: 149 LKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMF 208 Query: 247 STFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYS---QQPGADFLC 303 + ++M P L + + KVW+ H AWD IF+ CI Q + Q + Sbjct: 209 KSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVA 268 Query: 304 DIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDN 363 ++ LS + A EL +V+TT L+ L+ L+RNP Q+ L QE + Sbjct: 269 ELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASI 328 Query: 364 QTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLG 423 + +P L+A LKE++RL P F R VL Y +P GT++ + LG Sbjct: 329 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLG 388 Query: 424 SSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKY 483 + F ++ P+RWL F H+PFG G R C+GRRLAE ++ L L +++ Sbjct: 389 RNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 448 Query: 484 DIVATDNEPVEMLHLGILVPSRELPIAFR 512 + E ++M++ IL PS + FR Sbjct: 449 QVETLTQEDIKMVYSFILRPSMFPLLTFR 477 >5VEU-A nrPDB Length = 480 Score = 139 bits (349), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 127/477 (26%), Positives = 219/477 (45%), Gaps = 43/477 (9%) Query: 57 SLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLE 116 +PGPT PLLG++L ++ GL K DT E +KKYG+++ G + + P ++ Sbjct: 16 GIPGPTPLPLLGNVLS--YRQGLWK-FDT--ECYKKYGKMWGTYEGQLPVLAITDPDVIR 70 Query: 117 ALYRTE--SAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLM--KPVEI 172 + E S R + P + + + E +EW+R+RS K E+ Sbjct: 71 TVLVKECYSVFTNRRSLGPVGFMKS------AISLAEDEEWKRIRSLLSPTFTSGKLKEM 124 Query: 173 MKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQK--- 229 + + +VL L R E +G+ L +S + I + L Sbjct: 125 FPIIAQYGDVLVRNLRREAE----KGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQD 180 Query: 230 ---ETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCI 286 E+ ++ L F +S +TPV + LN ++ T+ + + KSV Sbjct: 181 PFVESTKKFLKFGFLDPLFLSIILFPFLTPV--FEALNVSLFPKDTINF--LSKSVNRMK 236 Query: 287 DNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAA---------VETTANSLMW 337 +RL Q+ DFL + + + E + A+++L+LAA ETT++ L + Sbjct: 237 KSRLND-KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSF 295 Query: 338 ILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRT 397 LY L+ +P Q++L +E+ +VLP+ P + + M YL + E++RL P RT Sbjct: 296 TLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERT 355 Query: 398 LDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGI 457 K + +PKG+++ + T L + + +FRPER+ +K+ I+P+ + PFG Sbjct: 356 CKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGT 415 Query: 458 GKRMCIGRRLAELQLHLALCWIIQKYDIVATDNE--PVEMLHLGILVPSRELPIAFR 512 G R CIG R A + + LAL ++Q + P+++ G+L P E PI + Sbjct: 416 GPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQP--EKPIVLK 470 >6DA2-A nrPDB Length = 487 Score = 128 bits (322), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 117/449 (26%), Positives = 202/449 (44%), Gaps = 44/449 (9%) Query: 57 SLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLE 116 +PGPT P LG++L + KG E HKKYG+++ G + + P +++ Sbjct: 17 GIPGPTPLPFLGNILS-YHKGFCMFD----MECHKKYGKVWGFYDGQQPVLAITDPDMIK 71 Query: 117 ALYRTE--SAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLM--KPVEI 172 + E S R P + + I E +EW+R+RS K E+ Sbjct: 72 TVLVKECYSVFTNRRPFGPVGFMKS------AISIAEDEEWKRLRSLLSPTFTSGKLKEM 125 Query: 173 MKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETE 232 + + + +VL L R E G+ L +S + V+ FG+ Sbjct: 126 VPIIAQYGDVLVRNLRREAE----TGKPVTLKDVFGAYSMD----VITSTSFGVNIDSLN 177 Query: 233 EEALTFITAIKTMM------STFGKMMVTP--VELHKRLNTKVWQAHTLAWDTIFKSVKP 284 F+ K ++ F + V P + + + LN V+ + + KSVK Sbjct: 178 NPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNF--LRKSVKR 235 Query: 285 CIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQL---------AAVETTANSL 335 ++RL+ +Q+ DFL + + + E + A+++L+L A ETT++ L Sbjct: 236 MKESRLED-TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVL 294 Query: 336 MWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT 395 +I+Y L+ +P Q++L +E+ +VLP+ P + + M YL + E++RL P Sbjct: 295 SFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLE 354 Query: 396 RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEK-KINPFAHLP 454 R K + +PKG V+ + + L + + KF PER+ +K K I+P+ + P Sbjct: 355 RVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTP 414 Query: 455 FGIGKRMCIGRRLAELQLHLALCWIIQKY 483 FG G R CIG R A + + LAL ++Q + Sbjct: 415 FGSGPRNCIGMRFALMNMKLALIRVLQNF 443 >5YLW-A nrPDB Length = 495 Score = 124 bits (310), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 113/472 (23%), Positives = 197/472 (41%), Gaps = 30/472 (6%) Query: 59 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLL-EA 117 PGP +P++G++L++ H A+ K+YG + + LGS +V + SP + E Sbjct: 30 PGPFPYPIVGNMLQLG-----ANPHQVFAKLSKRYGPLMSIHLGSLYTVIVSSPEMAKEI 84 Query: 118 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDK 177 L+R R + A DH + G + + EW+ +R ++++ + Sbjct: 85 LHRHGQVFSGRTIAQAVHAC-DHDKISMGFLPV-ASEWRDMRKICKEQMFSNQSMEASQG 142 Query: 178 KINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALT 237 + L L+ + + C + GR D+ + + L+ + + E Sbjct: 143 LRRQKLQQLLDHVQK-CSDSGRAVDIREAAFITTLNLMSATLFSSQATEFDSKATMEFKE 201 Query: 238 FITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQP 297 I + T++ P+ L V + + + + ++ ++ RL+ P Sbjct: 202 IIEGVATIVGVPNFADYFPI-LRPFDPQGVKRRADVFFGKLLAKIEGYLNERLESKRANP 260 Query: 298 GA----DFL---CDIYQQDHLSKKELYAA--VTELQLAAVETTANSLMWILYNLSRNPQA 348 A DFL DI Q + K + + +L + +T S+ W + L NP Sbjct: 261 NAPKKDDFLEIVVDIIQANEFKLKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDK 320 Query: 349 QRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTLDKPTVLGEY 407 RL E++SV D + + +PYL+A +KE MR+ P P R + + Y Sbjct: 321 MARLKAELKSVAGDEKIVDESAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGY 380 Query: 408 ALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQK--EKKINPFAHLPFGIGKRMCIGR 465 +PKGT + +N +G + D F PER+L + K + LPFG G+R+C G Sbjct: 381 LIPKGTQILINAYAIGRDPSIWTDPETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGM 440 Query: 466 RLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGIL--------VPSRELPI 509 LA LH+A ++ +D D+ H G L VP R +PI Sbjct: 441 PLATRILHMATATLVHNFDWKLEDDSTAAADHAGELFGVAVRRAVPLRIIPI 492 >6B82-A nrPDB Length = 509 Score = 117 bits (292), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 112/493 (22%), Positives = 215/493 (43%), Gaps = 53/493 (10%) Query: 52 TRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGS 111 R+ SLP + P++GSL+ + H + KKYG ++ + +GS Sbjct: 22 NRSPPSLP---SLPIIGSLMSLVSD---SPPHIFFQDLQKKYGDLYSLMMGSH------- 68 Query: 112 PSLLEALYRTESAHPQRLEIKPWKAYRDH-RNEAYGLMILEGQEWQRVRSA----FQKKL 166 + L H + + IK K + R L+ +G++ + F +K+ Sbjct: 69 ----KLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKM 124 Query: 167 MKPVEIM--KLDKKINEVLADFLERMDE-LCDERGRIPDLYSELNKWSFESICLVLYEKR 223 + M + I +++ M E L + + DL EL + +C + + Sbjct: 125 VHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSS 184 Query: 224 FGLLQKETEE-----EALTFITAIKTMMSTFGKMMVTP----------VELHKRLNTKVW 268 + E E + + A +++ F + + P + + +L K + Sbjct: 185 YKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLRILRQCISIRDKLLQKKY 244 Query: 269 QAHTLAW-DTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAA 327 + H + + D + + + + R +R S+ + +DH+ V E+ A Sbjct: 245 EEHKVTYSDNVQRDLLDAL-LRAKRSSENNNSSTRDVGLTEDHV-----LMTVGEIFGAG 298 Query: 328 VETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRL 387 VETT +L W + L NPQ QR++ +E+ S + + P+ D N+PYL+A + E MR+ Sbjct: 299 VETTTTTLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRI 358 Query: 388 TPSVPFTTRTLD-KPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKK 446 P P + + + +GEY + KGT + +N L E +++ F P R+L +E Sbjct: 359 RPVSPLLIPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGD 418 Query: 447 ---INPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLH--LGIL 501 ++LPFG G R+C+G LA+++L L L WI+Q++ + +P+ L G++ Sbjct: 419 GLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVV 478 Query: 502 VPSRELPIAFRPR 514 + ++ + + R Sbjct: 479 LQPKKFKVVAKVR 491 >6C94-A nrPDB Length = 497 Score = 115 bits (288), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 112/446 (25%), Positives = 201/446 (45%), Gaps = 41/446 (9%) Query: 55 VTSLPGP-TNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSF-DSVHLGSP 112 + S PGP T+W L G LEI G L D + + +++ + +G F +++ P Sbjct: 21 MDSFPGPPTHW-LFGHALEIQKTGSL----DKVVTWTQQFPYAHPLWVGQFIGFLNIYEP 75 Query: 113 SLLEALY-RTESAHPQRLEIK-PWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPV 170 +A+Y R + P + W GL++L+G +W + R KL+ P Sbjct: 76 DYAKAVYSRGDPKAPDVYDFFLQWIGK--------GLLVLDGPKWFQHR-----KLLTPG 122 Query: 171 EIMKLDKKINEVLADFLERMDELCDER---GRIPDLYSELNKWSFESICLVLYEK-RFGL 226 + K + AD M E +++ G+ D++S++ + +++ + K GL Sbjct: 123 FHYDVLKPYVAIFADSTRIMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSGL 182 Query: 227 LQKETEE----EALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSV 282 +++ LT + + + + + H R + +A D + + Sbjct: 183 NHRDSSYYVAVSELTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACRAAHDHTDRVIRQR 242 Query: 283 KPCIDN-----RLQRYSQQPGADFLCDIYQQD--HLSKKELYAAVTELQLAAVETTANSL 335 K + + ++Q D L D+ + LS +L A V +TT + + Sbjct: 243 KAALQDEKEREKIQNRRHLDFLDILLDVRGESGVQLSDTDLRAEVDTFMFEGHDTTTSGI 302 Query: 336 MWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT 395 W LY ++ P+ Q+R +EV+ +L D + + EDL M YL C+KE RL P VP Sbjct: 303 SWFLYCMALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVY 362 Query: 396 RTLDKP-TVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWL-QKEKKINPFAHL 453 R L KP + + +LP G++++L+ L + D + D F P R+ + +P+A + Sbjct: 363 RQLSKPVSFVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAFI 422 Query: 454 PFGIGKRMCIGRRLA--ELQLHLALC 477 PF G R CIG++ A E+++ ALC Sbjct: 423 PFSAGPRNCIGQQFAMNEMKVVTALC 448 >2PG7-A nrPDB Length = 476 Score = 111 bits (277), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 120/492 (24%), Positives = 215/492 (43%), Gaps = 68/492 (13%) Query: 59 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEA 117 PGPT P +G+ L++ ++ +++L + ++YG +F + LG V L G ++ EA Sbjct: 13 PGPTPLPFIGNYLQL----NTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREA 68 Query: 118 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK--L 175 L R E +A D + YG++ G+ +++R F ++ + K + Sbjct: 69 LVDQAEEFSGRGE----QATFDWVFKGYGVVFSNGERAKQLRR-FSIATLRDFGVGKRGI 123 Query: 176 DKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEA 235 +++I E A FL +D L G D L++ I +++ RF KE Sbjct: 124 EERIQEE-AGFL--IDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKE----- 175 Query: 236 LTFITAIKTMMSTF-------GKMMVTPVELHKRLNTKVWQAHTLAW---DTIFKSV--- 282 F++ ++ M+ F G++ + K L QA L D I K V Sbjct: 176 --FLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHN 233 Query: 283 ---------KPCIDN---RLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVET 330 + ID+ R+Q + P +F K L +L + ET Sbjct: 234 QRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYL----------KNLVMTTLQLFVGGTET 283 Query: 331 TANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPS 390 + +L + L ++P+ + ++ +E+ V+ N+ P+ ED MPY++A + E R Sbjct: 284 VSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDV 343 Query: 391 VPFT-TRTLDKPTVLGEYALPKGTVLTLNTQVLGS---SEDNFEDSHKFRPERWLQKEKK 446 +P + R + K T ++ LPKGT + +LGS F + F P+ +L ++ + Sbjct: 344 IPMSLARRVKKDTKFRDFFLPKGTEVY---PMLGSVLRDPSFFSNPQDFNPQHFLNEKGQ 400 Query: 447 INPF-AHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEP---VEMLHLGILV 502 A +PF IGKR C G LA ++L L ++Q + + ++ + V H+G Sbjct: 401 FKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFAT 460 Query: 503 PSRELPIAFRPR 514 R ++F PR Sbjct: 461 IPRNYTMSFLPR 472 >5UYS-A nrPDB Length = 494 Score = 111 bits (277), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 101/451 (22%), Positives = 204/451 (45%), Gaps = 40/451 (8%) Query: 65 PLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLL-EALYRTES 123 PL+GSL + G + H+ + KKYG I+ +++G+ +V +G L E L + Sbjct: 17 PLVGSLPFLPRHGHM---HNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGK 73 Query: 124 AHPQRLEIKPWKAYRDHRNEAYGLMILE-GQEWQRVRSAFQKKLMKPVEIMK-LDKKINE 181 R ++ ++R G+ + G WQ R + M + K D+K+ + Sbjct: 74 DFSGRPQMATLDIASNNRK---GIAFADSGAHWQLHR----RLAMATFALFKDGDQKLEK 126 Query: 182 VLADFLERM-DELCDERGRIPDLYSELNKWSFESICLVLYEKRF---------------G 225 ++ + + D L G+ D+ + I L+ + + G Sbjct: 127 IICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEG 186 Query: 226 LLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAW--DTIFKSVK 283 ++ +++ + + +K + + + + V++ L K+ + + + D+I + Sbjct: 187 IIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLD 246 Query: 284 PCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLS 343 + ++ + G D ++ +H+ + ++ A VETT + + W L L Sbjct: 247 TLMQAKMNSDNGNAGPDQDSELLSDNHI-----LTTIGDIFGAGVETTTSVVKWTLAFLL 301 Query: 344 RNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVP-FTTRTLDKPT 402 NPQ +++L +E+ + ++TP D + L+A ++E +RL P P + + Sbjct: 302 HNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDS 361 Query: 403 VLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQ--KEKKINP-FAHLPFGIGK 459 +GE+A+ KGT + +N L +E + +F PER+L + I+P ++LPFG G Sbjct: 362 SIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGP 421 Query: 460 RMCIGRRLAELQLHLALCWIIQKYDIVATDN 490 R CIG LA +L L + W++Q++D+ D+ Sbjct: 422 RSCIGEILARQELFLIMAWLLQRFDLEVPDD 452 >4H1N-A nrPDB Length = 479 Score = 108 bits (271), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 117/457 (25%), Positives = 203/457 (44%), Gaps = 55/457 (12%) Query: 59 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEA 117 PGP+ P+LG+LL++ KG L+ + +KYG +F + LGS V L G+ ++ EA Sbjct: 13 PGPSPLPVLGNLLQMDRKGLLR----SFLRLREKYGDVFTVYLGSRPVVVLCGTDAIREA 68 Query: 118 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK--L 175 L A R +I A D + YG++ G+ W+ +R F M+ + K + Sbjct: 69 LVDQAEAFSGRGKI----AVVDPIFQGYGVIFANGERWRALRR-FSLATMRDFGMGKRSV 123 Query: 176 DKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGL--------- 226 +++I E +E EL +G + D + + IC +++ KRF Sbjct: 124 EERIQEEARCLVE---ELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLL 180 Query: 227 -LQKETEEEALTFITAIKTMMSTFGKMM-VTPVELHKRL---NTKVWQA---HTLAWDTI 278 L ++ +F + + + S F K T ++++ L NT + Q+ H D Sbjct: 181 DLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDP- 239 Query: 279 FKSVKPCIDN---RLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSL 335 + + ID R+++ P ++F + L V L A ETT+ +L Sbjct: 240 -SNPRDFIDVYLLRMEKDKSDPSSEF----------HHQNLILTVLSLFAAGTETTSTTL 288 Query: 336 MWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT 395 + + + P R+ +E++ V+ ++ P +D MPY A + E RL +PF Sbjct: 289 RYGFLLMLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGV 348 Query: 396 -RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDN---FEDSHKFRPERWLQKEKKINPF- 450 T+ K T Y +PK T + VL S+ + FE + F P +L + Sbjct: 349 PHTVTKDTQFRGYVIPKNTEV---FPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNE 405 Query: 451 AHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVA 487 +PF +GKR+C+G +A +L L I+Q + I + Sbjct: 406 GFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIAS 442 >4R1Z-A nrPDB Length = 439 Score = 107 bits (267), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 113/210 (53%), Gaps = 6/210 (2%) Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED 370 L++ + V ++ A VETT L W + L NPQ QR++ +E+ S + + P+ D Sbjct: 218 LTEDHVLMTVGDIFGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSD 277 Query: 371 LRNMPYLKACLKESMRLTPSVPFTTRTLD-KPTVLGEYALPKGTVLTLNTQVLGSSEDNF 429 N+PYL+A ++E +R+ P P + + + +GEY + KGT + +N L + + Sbjct: 278 RGNLPYLEATIREVLRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEW 337 Query: 430 EDSHKFRPERWLQKEKK---INPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIV 486 ++ F P R+L +E ++LPFG G R+C+G LA+++L L L WI+Q++ + Sbjct: 338 KNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLE 397 Query: 487 ATDNEPVEMLH--LGILVPSRELPIAFRPR 514 +P+ L G+++ ++ + + R Sbjct: 398 MPTGQPLPDLQGKFGVVLQPKKFKVVAKVR 427 >3E6I-A nrPDB Length = 476 Score = 105 bits (262), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 109/472 (23%), Positives = 211/472 (44%), Gaps = 46/472 (9%) Query: 59 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEA 117 PGP P++G+L ++ K + K LA+ ++G +F + +GS V + G ++ EA Sbjct: 13 PGPFPLPIIGNLFQLELKN-IPKSFTRLAQ---RFGPVFTLYVGSQRMVVMHGYKAVKEA 68 Query: 118 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKL-- 175 L + R ++ + A+RD G++ G W+ +R F ++ + K Sbjct: 69 LLDYKDEFSGRGDLPAFHAHRDR-----GIIFNNGPTWKDIRR-FSLTTLRNYGMGKQGN 122 Query: 176 DKKINEVLADFLERMDEL------------CDERGRIPDL----YSELNKWSFESICLVL 219 + +I LE + + C I D+ + + N F + + L Sbjct: 123 ESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL-MYL 181 Query: 220 YEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIF 279 + + F LL + F + + + + K++ E+ + ++ +V + H Sbjct: 182 FNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCP 241 Query: 280 KSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWIL 339 + + C+ +++ ++ A+ L Y D ++ V +L A ETT+ +L + L Sbjct: 242 RDLTDCLLVEMEK--EKHSAERL---YTMDGIT-----VTVADLFFAGTETTSTTLRYGL 291 Query: 340 YNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTL 398 L + P+ + +L +E+ V+ ++ P +D + MPY+ A + E R VP Sbjct: 292 LILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEA 351 Query: 399 DKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHL-PFGI 457 + T+ Y +PKGTV+ + F D KF+PE +L + K + PF Sbjct: 352 TRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFST 411 Query: 458 GKRMCIGRRLAELQLHLALCWIIQKYDIVA-TDNEPVEM--LHLGI-LVPSR 505 GKR+C G LA ++L L LC I+Q +++ D + +++ +H+G +P R Sbjct: 412 GKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR 463 >4GQS-A nrPDB Length = 477 Score = 99.4 bits (246), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 111/453 (24%), Positives = 196/453 (43%), Gaps = 51/453 (11%) Query: 59 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEA 117 PGPT P++G++L+I +K +L K YG +F + G V L G + EA Sbjct: 14 PGPTPLPVIGNILQI----DIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEA 69 Query: 118 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK--L 175 L R + N +G++ G+ W+ +R F ++ + K + Sbjct: 70 LIDLGEEFSGRGHF----PLAERANRGFGIVFSNGKRWKEIRR-FSLMTLRNFGMGKRSI 124 Query: 176 DKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRF--------GLL 227 + ++ E +E EL + D L IC ++++KRF L+ Sbjct: 125 EDRVQEEARCLVE---ELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLM 181 Query: 228 QKETEEEAL----------TFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDT 277 +K E + F T I T K++ + + KV + H + D Sbjct: 182 EKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKV-KEHQESMD- 239 Query: 278 IFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMW 337 + + ID L + ++ QQ + + L +L A ETT+ +L + Sbjct: 240 -INNPRDFIDCFLIKMEKEKQN-------QQSEFTIENLVITAADLLGAGTETTSTTLRY 291 Query: 338 ILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT-R 396 L L ++P+ ++ +E++ V+ N++P +D +MPY A + E R +P + Sbjct: 292 ALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPH 351 Query: 397 TLDKPTVLGEYALPKG-TVLTLNTQVLGSSEDNFEDSHKFRPERWLQKE---KKINPFAH 452 + Y +PKG T+LT T VL +++ F + F P +L + KK N F Sbjct: 352 AVTCDVKFRNYLIPKGTTILTSLTSVLHDNKE-FPNPEMFDPRHFLDEGGNFKKSNYF-- 408 Query: 453 LPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI 485 +PF GKR+C+G LA ++L L L +I+Q +++ Sbjct: 409 MPFSAGKRICVGEGLARMELFLFLTFILQNFNL 441 >3IBD-A nrPDB Length = 476 Score = 98.6 bits (244), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 104/439 (23%), Positives = 181/439 (41%), Gaps = 39/439 (8%) Query: 69 SLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEALYRTESAHPQ 127 +LL++ +G LK + + +KYG +F + LG V L G ++ EAL A Sbjct: 23 NLLQMDRRGLLK----SFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSG 78 Query: 128 RLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK--LDKKINEVLAD 185 R +I A D YG++ G W+ +R F M+ + K ++++I E Sbjct: 79 RGKI----AMVDPFFRGYGVIFANGNRWKVLRR-FSVTTMRDFGMGKRSVEERIQEEAQC 133 Query: 186 FLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTM 245 +E EL +G + D + IC +++ KRF +E + F + Sbjct: 134 LIE---ELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLI 190 Query: 246 MSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQ--QPGADF-L 302 S FG++ EL AH + + + + I + ++++ + P A L Sbjct: 191 SSVFGQLF----ELFSGFLKHFPGAHRQVYKNL-QEINAYIGHSVEKHRETLDPSAPRDL 245 Query: 303 CDIY----------QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRL 352 D Y S + L L A ETT+ +L + + + P R+ Sbjct: 246 IDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERV 305 Query: 353 LQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTLDKPTVLGEYALPK 411 +E++ V+ ++ P D MPY +A + E R + +P + + T Y +PK Sbjct: 306 YREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPK 365 Query: 412 GTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKE---KKINPFAHLPFGIGKRMCIGRRLA 468 T + L FE F P+ +L KK F +PF +GKR+C+G +A Sbjct: 366 DTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAF--IPFSLGKRICLGEGIA 423 Query: 469 ELQLHLALCWIIQKYDIVA 487 +L L I+Q + + + Sbjct: 424 RAELFLFFTTILQNFSMAS 442 >6DWN-A nrPDB Length = 491 Score = 98.6 bits (244), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 101/471 (21%), Positives = 201/471 (42%), Gaps = 41/471 (8%) Query: 52 TRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-G 110 ++ + + PGP WPL+G +L + K H L+ ++YG + ++++GS V L G Sbjct: 7 SKGLKNPPGPWGWPLIGHMLTLG-----KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 61 Query: 111 SPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPV 170 ++ +AL R R ++ + + ++ ++ G W R Q L K Sbjct: 62 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPD--SGPVWAARRRLAQNGL-KSF 118 Query: 171 EIMK---------LDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYE 221 I L++ +++ + + EL G + Y + IC + + Sbjct: 119 SIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHF-NPYRYVVVSVTNVICAICFG 177 Query: 222 KRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPV---------ELHKRLNTKVWQAHT 272 +R+ +E ++ + P+ K LN K + Sbjct: 178 RRYDHNHQELLSLVNL-NNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQ 236 Query: 273 LAWDTIFKSVKPC----IDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAV 328 +K+ + I + L + Q+ D ++ LS +++ V +L A Sbjct: 237 KMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV----QLSDEKIINIVLDLFGAGF 292 Query: 329 ETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLT 388 +T ++ W L L NP+ QR++ +E+ +V+ ++ PR D ++PY++A + E+ R + Sbjct: 293 DTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHS 352 Query: 389 PSVPFTT-RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKI 447 VPFT + + T L + +PKG + +N + + + + +F PER+L + I Sbjct: 353 SFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAI 412 Query: 448 NPFAH---LPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEM 495 + + FG+GKR CIG +A ++ L L ++Q+ + V+M Sbjct: 413 DKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDM 463 >3MDV-A nrPDB Length = 456 Score = 98.2 bits (243), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 67/227 (29%), Positives = 110/227 (48%), Gaps = 4/227 (1%) Query: 290 LQRYSQQPGADFLCDIYQQDHLSKKE--LYAAVTELQLAAVETTANSLMWILYNLSRNPQ 347 L+R + P AD L I + + ++ + L +A ET+AN L + + LSR P+ Sbjct: 217 LKRGEEVP-ADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPE 275 Query: 348 AQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEY 407 RL EV V+ + EDL + YL LKES+RL P T R L++ T++ Sbjct: 276 IVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGV 335 Query: 408 ALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRL 467 +P T L +T V+G + FED F P+R+ K F + PF +G R CIG++ Sbjct: 336 RVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR-FTYFPFSLGHRSCIGQQF 394 Query: 468 AELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRPR 514 A++++ + + ++Q+ + + + L P + RPR Sbjct: 395 AQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPR 441 >2NNH-A nrPDB Length = 476 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 114/471 (24%), Positives = 202/471 (42%), Gaps = 77/471 (16%) Query: 59 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEA 117 PGPT P++G++L+I K K + + K YG +F + G V G ++ EA Sbjct: 13 PGPTPLPIIGNMLQIDVKDICK----SFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEA 68 Query: 118 LY--------RTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKP 169 L R S QR+ + G++ G+ W+ +R F ++ Sbjct: 69 LIDNGEEFSGRGNSPISQRI------------TKGLGIISSNGKRWKEIRR-FSLTTLRN 115 Query: 170 VEIMK--LDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLL 227 + K ++ ++ E +E EL + D L IC V+++KRF Sbjct: 116 FGMGKRSIEDRVQEEAHCLVE---ELRKTKASPCDPTFILGCAPCNVICSVVFQKRF--- 169 Query: 228 QKETEEEALTFITAIKTMMSTFGKMMVTP-----------VELHKRLNTKVWQAHTLAWD 276 + + F+T +K F +++ +P ++ + KV + L Sbjct: 170 ----DYKDQNFLTLMKRFNENF-RILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRS 224 Query: 277 TIFKSVK------------PCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQ 324 I + VK ID L + Q+ Q+ + + L V +L Sbjct: 225 YIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDN-------QKSEFNIENLVGTVADLF 277 Query: 325 LAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKES 384 +A ETT+ +L + L L ++P+ ++ +E+ V+ +++P +D +MPY A + E Sbjct: 278 VAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEI 337 Query: 385 MRLTPSVPFTT-RTLDKPTVLGEYALPKGT-VLTLNTQVLGSSEDNFEDSHKFRPERWLQ 442 R + VP + T Y +PKGT ++ L T VL ++ F + + F P +L Sbjct: 338 QRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKE-FPNPNIFDPGHFLD 396 Query: 443 KE---KKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDN 490 K KK + F +PF GKR+C G LA ++L L L I+Q +++ + D+ Sbjct: 397 KNGNFKKSDYF--MPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDD 445 >4R20-A nrPDB Length = 486 Score = 96.3 bits (238), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 86/317 (27%), Positives = 143/317 (45%), Gaps = 27/317 (8%) Query: 188 ERMDELCDE----RGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETE-----EEALTF 238 E D LC+E RG+ DL L + IC +++ + E + + + Sbjct: 140 EAADSLCEELQACRGQSSDLSVVLMRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQ 199 Query: 239 ITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIF---KSVKP-----CIDNRL 290 A ++ F + + P + KRL V L + + KS+ P +D L Sbjct: 200 TIARGGLVDIFPWLRIFPNKDLKRLKECVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALL 259 Query: 291 QRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQR 350 QQ G+ DI +DH+ E A VETT+ +L+W + L +PQ Q Sbjct: 260 --IGQQRGSGGADDI-TEDHV-----LMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQE 311 Query: 351 RLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVP-FTTRTLDKPTVLGEYAL 409 R+ E+ + ++ P D ++P L A L E MR+ P P + T LG +++ Sbjct: 312 RVQAELDECVGVDRPPCLSDRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSV 371 Query: 410 PKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKE-KKINPFAHLPFGIGKRMCIGRRLA 468 PKGT + +N + +++ +F PER+L+ KK + LPFG G R+C+G LA Sbjct: 372 PKGTRVLVNMWAIHHDPKHWDQPEQFNPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLA 431 Query: 469 ELQLHLALCWIIQKYDI 485 ++L L + +Q++ Sbjct: 432 RIELFLFVSRPLQRFSF 448 >6IQ5-A nrPDB Length = 463 Score = 96.3 bits (238), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 104/442 (23%), Positives = 189/442 (42%), Gaps = 32/442 (7%) Query: 80 KKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEALYRTESAHPQRLEIKPWKAYR 138 + H + A ++YG +F+++LGS V L G ++ +AL + SA R ++ Sbjct: 1 QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVS 60 Query: 139 DHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINE--VLADFLERMDELCDE 196 R+ A+G + W+ R A + +++ E VL++ E + L Sbjct: 61 GGRSMAFGHY---SEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLV-- 115 Query: 197 RGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTP 256 RG + + + ++ V+ FG + E ++ + T G + Sbjct: 116 RGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVD 175 Query: 257 VELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRY--SQQPGA---DFL-CDIYQQDH 310 V + + ++ + ++ I ++ R+ S +PGA D + I + Sbjct: 176 VMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEK 235 Query: 311 LSKKELYAAVTELQL------------AAVETTANSLMWILYNLSRNPQAQRRLLQEVQS 358 + + + L L A+ +T + +L W+L +R P Q R+ E+ Sbjct: 236 KAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQ 295 Query: 359 VLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT--RTLDKPTVLGEYALPKGTVLT 416 V+ ++ P D N+PY+ A L E+MR + VP T T +VLG Y +PK TV+ Sbjct: 296 VVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLG-YHIPKDTVVF 354 Query: 417 LNTQVLGSSEDNFEDSHKFRPERWLQKEKKIN---PFAHLPFGIGKRMCIGRRLAELQLH 473 +N + + + F P R+L K+ IN + F +GKR CIG L+++QL Sbjct: 355 VNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLF 414 Query: 474 LALCWIIQKYDIVATDNEPVEM 495 L + + + D A NEP +M Sbjct: 415 LFISILAHQCDFRANPNEPAKM 436 >3QZ1-A nrPDB Length = 496 Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 67/201 (33%), Positives = 103/201 (51%), Gaps = 20/201 (9%) Query: 291 QRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQR 350 QR + PG L + ++ +V +L + ETTA++L W + L +P+ QR Sbjct: 266 QRVEEGPG-----------QLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQR 314 Query: 351 RLLQEVQSVL-PDNQTPRA--EDLRNMPYLKACLKESMRLTPSVPFTT--RTLDKPTVLG 405 RL +E+ L P R +D +P L A + E +RL P VP RT ++ G Sbjct: 315 RLQEELDRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFG 374 Query: 406 EYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGR 465 Y +P+G V+ N Q E +E H+FRP+R+L E NP A L FG G R+C+G Sbjct: 375 -YDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFL--EPGANPSA-LAFGCGARVCLGE 430 Query: 466 RLAELQLHLALCWIIQKYDIV 486 LA L+L + L ++Q + ++ Sbjct: 431 SLARLELFVVLARLLQAFTLL 451 >5VBU-A nrPDB Length = 476 Score = 95.1 bits (235), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 60/185 (32%), Positives = 99/185 (53%), Gaps = 9/185 (4%) Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVL-PDNQTPRA- 368 L + ++ A +L + ETTAN+L W + L +P+ Q+RL +E+ L P + R Sbjct: 258 LLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP 317 Query: 369 -EDLRNMPYLKACLKESMRLTPSVPFTT--RTLDKPTVLGEYALPKGTVLTLNTQVLGSS 425 +D +P L A + E +RL P VP RT +P+ + Y +P+GTV+ N Q Sbjct: 318 YKDRARLPLLNATIAEVLRLRPVVPLALPHRT-TRPSSISGYDIPEGTVIIPNLQGAHLD 376 Query: 426 EDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI 485 E +E H+F P+R+L+ K A FG G R+C+G LA L+L + L ++Q + + Sbjct: 377 ETVWERPHEFWPDRFLEPGKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFTL 433 Query: 486 VATDN 490 + + + Sbjct: 434 LPSGD 438 >2HI4-A nrPDB Length = 495 Score = 94.7 bits (234), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 106/466 (22%), Positives = 197/466 (42%), Gaps = 54/466 (11%) Query: 53 RNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGS- 111 + + S P P WPLLG +L + K H L+ ++YG + ++++GS + L Sbjct: 13 KGLKSPPEPWGWPLLGHVLTLG-----KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRL 67 Query: 112 PSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKL----- 166 ++ +AL R R ++ D ++ + G W R Q L Sbjct: 68 DTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTD--SGPVWAARRRLAQNALNTFSI 125 Query: 167 -MKPVEIMK--LDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKR 223 P L++ +++ + R+ EL G D Y+++ S+ V+ Sbjct: 126 ASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHF-DPYNQV----VVSVANVIGAMC 180 Query: 224 FGLLQKETEEEALTFITAIKTMMST---------FGKMMVTPVELHKRLNT--------- 265 FG E+ +E L+ + + T F + P +R Sbjct: 181 FGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFL 240 Query: 266 -KVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQ 324 K Q H +D SV+ + + P A + + ++++ V ++ Sbjct: 241 QKTVQEHYQDFDK--NSVRDITGALFKHSKKGPRAS-------GNLIPQEKIVNLVNDIF 291 Query: 325 LAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKES 384 A +T ++ W L L P+ QR++ +E+ +V+ + PR D +PYL+A + E+ Sbjct: 292 GAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILET 351 Query: 385 MRLTPSVPFTT-RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQK 443 R + +PFT + + T L + +PK + +N + + +ED +FRPER+L Sbjct: 352 FRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTA 411 Query: 444 E-KKIN-PFAH--LPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI 485 + IN P + + FG+GKR CIG LA+ ++ L L ++Q+ + Sbjct: 412 DGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEF 457 >5W0C-A nrPDB Length = 477 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 100/440 (22%), Positives = 190/440 (43%), Gaps = 25/440 (5%) Query: 59 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEA 117 PGPT P++G++L+I G+K +L K YG +F + G V L G ++ EA Sbjct: 14 PGPTPLPVIGNILQI----GIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEA 69 Query: 118 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK--L 175 L R I P + N +G++ G++W+ +R F ++ + K + Sbjct: 70 LIDLGEEFSGR-GIFPLA---ERANRGFGIVFSNGKKWKEIRR-FSLMTLRNFGMGKRSI 124 Query: 176 DKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEA 235 + ++ E +E EL + D L IC +++ KRF ++ Sbjct: 125 EDRVQEEARCLVE---ELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLM 181 Query: 236 LTFITAIKTMMSTFGKMM--VTPV-ELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQR 292 IK + S + ++ +P+ + + K+ + I + VK ++ Sbjct: 182 EKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMN 241 Query: 293 YSQQPGADFLCDIYQQDH-----LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQ 347 Q FL + ++ H + + L +L A ETT+ +L + L L ++P+ Sbjct: 242 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 301 Query: 348 AQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTLDKPTVLGE 406 ++ +E++ V+ N++P +D +MPY A + E R +P + + Sbjct: 302 VTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRN 361 Query: 407 YALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAH-LPFGIGKRMCIGR 465 Y +PKGT + ++ + F + F P +L + + +PF GKR+C+G Sbjct: 362 YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGE 421 Query: 466 RLAELQLHLALCWIIQKYDI 485 LA ++L L L I+Q +++ Sbjct: 422 ALAGMELFLFLTSILQNFNL 441 >3DL9-A nrPDB Length = 479 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 53/177 (29%), Positives = 88/177 (49%), Gaps = 2/177 (1%) Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED 370 SK+ L +V EL +A ETT N L W + ++ P Q ++ +E+ ++ N P +D Sbjct: 269 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 328 Query: 371 LRNMPYLKACLKESMRLTPSVPFTT-RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNF 429 MPY +A L E +R VP + V+ Y++PKGT + N + E + Sbjct: 329 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 388 Query: 430 EDSHKFRPERWLQKEKKI-NPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI 485 D F PER+L A +PF +G+R C+G LA +++ L ++Q++ + Sbjct: 389 RDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 445 >3EL3-A nrPDB Length = 467 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 70/270 (25%), Positives = 124/270 (45%), Gaps = 21/270 (7%) Query: 235 ALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYS 294 A F + M+ G + P+ ++R N + H L + I + +R S Sbjct: 188 ATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAE----------RRAS 237 Query: 295 QQPGADFLCDIYQQ-----DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQ 349 Q D L + + D + ++E++ V + ET A+++MW+L L+ +P+ Sbjct: 238 GQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHA 297 Query: 350 RRLLQEVQSVLPDNQTPRA-EDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYA 408 R+ EV++V P A ED+R + + + E+MRL P+V TR + LG Y Sbjct: 298 DRIRDEVEAVT--GGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYR 355 Query: 409 LPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWL-QKEKKINPFAHLPFGIGKRMCIGRRL 467 +P G + + + +++D+ +F P+RWL ++ + +A PF GKR C Sbjct: 356 IPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHF 415 Query: 468 AELQLHLALCWIIQKY--DIVATDNEPVEM 495 + QL L + KY + VA N+ V + Sbjct: 416 SMAQLTLITAALATKYRFEQVAGSNDAVRV 445 >3TBG-A nrPDB Length = 479 Score = 91.3 bits (225), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 54/187 (28%), Positives = 87/187 (46%), Gaps = 2/187 (1%) Query: 308 QDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPR 367 + + + L V +L A + TT+ +L W L + +P QRR+ QE+ V+ + P Sbjct: 265 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPE 324 Query: 368 AEDLRNMPYLKACLKESMRLTPSVPF-TTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSE 426 D +MPY A + E R VP T + + + +PKGT L N + E Sbjct: 325 MGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDE 384 Query: 427 DNFEDSHKFRPERWLQKEKK-INPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI 485 +E +F PE +L + + P A LPF G+R C+G LA ++L L ++Q + Sbjct: 385 AVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF 444 Query: 486 VATDNEP 492 +P Sbjct: 445 SVPTGQP 451 >1N6B-A nrPDB Length = 473 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 108/444 (24%), Positives = 192/444 (43%), Gaps = 36/444 (8%) Query: 59 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEA 117 PGPT +P++G++L+I K +L ++ + YG +F + LG +V L G ++ EA Sbjct: 13 PGPTPFPIIGNILQI----DAKDISKSLTKFSECYGPVFTVYLGMKPTVVLHGYEAVKEA 68 Query: 118 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK--L 175 L R + + ++ G+ + W+ +R F ++ + K + Sbjct: 69 LVDLGEEFAGRGSVPILEKV----SKGLGIAFSNAKTWKEMRR-FSLMTLRNFGMGKRSI 123 Query: 176 DKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGL-------LQ 228 + +I E +E EL D L IC V++ RF L Sbjct: 124 EDRIQEEARCLVE---ELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKLM 180 Query: 229 KETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDN 288 + E T + + F ++ +HK L + + + K N Sbjct: 181 ESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDVN 240 Query: 289 RLQRYSQQPGADFLCDIYQQDHL--SKKELYAAVTELQLAAVETTANSLMWILYNLSRNP 346 + + FL + Q+++L + + L AV++L A ETT+ +L + L L ++P Sbjct: 241 NPRDFIDC----FLIKMEQENNLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHP 296 Query: 347 QAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTLDKPTVLG 405 + R+ +E++ V+ +++P +D MPY A + E R +P + + Sbjct: 297 EVAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFR 356 Query: 406 EYALPKGT-VLTLNTQVLGSSEDNFEDSHKFRPERWLQKE---KKINPFAHLPFGIGKRM 461 Y +PKGT ++T T VL E F + F P +L + KK + F +PF GKRM Sbjct: 357 NYFIPKGTDIITSLTSVL-HDEKAFPNPKVFDPGHFLDESGNFKKSDYF--MPFSAGKRM 413 Query: 462 CIGRRLAELQLHLALCWIIQKYDI 485 C+G LA ++L L L I+Q + + Sbjct: 414 CVGEGLARMELFLFLTSILQNFKL 437 >6AYB-A nrPDB Length = 466 Score = 88.6 bits (218), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 44/162 (27%), Positives = 84/162 (51%), Gaps = 1/162 (0%) Query: 325 LAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKES 384 A T++ + W L N+ N + ++ +E + ++ ++ + + M YL+AC+KE+ Sbjct: 267 FAGQHTSSITSSWTLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEA 326 Query: 385 MRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQ-K 443 +R+ P + R KP +Y +PKG +L ++ V G D + + F PER + K Sbjct: 327 LRMYPPLIMIMRMARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERLTERK 386 Query: 444 EKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI 485 E + + +PFG G+ CIG A LQ+ + +++ +D+ Sbjct: 387 EHEKFKYGAVPFGAGRHKCIGENFALLQVKSIISILLRYFDM 428 >2VE3-A nrPDB Length = 444 Score = 85.9 bits (211), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 59/188 (31%), Positives = 92/188 (48%), Gaps = 3/188 (1%) Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED 370 LS EL + L A ET ++L L ++ + R+ QE Q+ L +Q AE Sbjct: 239 LSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQE-QNKLQLSQELTAET 297 Query: 371 LRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFE 430 L+ MPYL L+E +RL P V R L + + PKG +++ + D + Sbjct: 298 LKKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQGFHFPKGWLVSYQISQTHADPDLYP 357 Query: 431 DSHKFRPERWLQKEKKIN--PFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVAT 488 D KF PER+ + PFAH+PFG G R C+G+ A L++ L +IQ++D Sbjct: 358 DPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKLFATRLIQQFDWTLL 417 Query: 489 DNEPVEML 496 + +E++ Sbjct: 418 PGQNLELV 425 >5E58-A nrPDB Length = 493 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 99/417 (23%), Positives = 166/417 (39%), Gaps = 33/417 (7%) Query: 91 KKYGQIFRMKLGSFDSVHL-GSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMI 149 +KYG +F + LG V L G+ ++ EAL A R I K YG++ Sbjct: 60 EKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTIAVIKPVIGD----YGMIF 115 Query: 150 LEGQEWQRVRSAFQKKLMKPVEIMK--LDKKINEVLADFLERMDELCDERGRIPDLYSEL 207 G+ W+ +R F M+ + K ++ +I E +E EL +G D Sbjct: 116 SNGERWKVLRR-FSLATMRDFGMGKRSVEDRIQEEAQCLVE---ELQKSQGAPLDPTFLF 171 Query: 208 NKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKV 267 + IC +++ +R+ ++ L ++MS+F + EL Sbjct: 172 QCITANIICSIVFGERYDYKDRQFLR-LLDLFYRTFSLMSSFSSQVF---ELFSGFMKYF 227 Query: 268 WQAH---TLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIY----------QQDHLSKK 314 AH T I V ++ DF+ D Y Q + Sbjct: 228 PGAHRQITRNLQEILDYVGQSVEKHRATLDPSNPRDFI-DTYLLRMEKEKSNQHTEFHHQ 286 Query: 315 ELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNM 374 L +V L A ETT+ +L + + + P ++ +E+ V+ ++ P ED M Sbjct: 287 NLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLEDRTKM 346 Query: 375 PYLKACLKESMRLTPSVPFTT-RTLDKPTVLGEYALPKGT-VLTLNTQVLGSSEDNFEDS 432 PY A + E R + P + K T+ Y LPK T V + + L + FE Sbjct: 347 PYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQ-YFEQP 405 Query: 433 HKFRPERWLQKEKKINPF-AHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVAT 488 F P+ +L + A +PF IGKR+C+G +A +L L I+Q + + ++ Sbjct: 406 GTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSVSSS 462 >3JUS-A nrPDB Length = 461 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 57/229 (24%), Positives = 108/229 (47%), Gaps = 13/229 (5%) Query: 269 QAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDH-----LSKKELYAAVTEL 323 +AH D +K+++ +R SQ+ D L + + L+ E+ + L Sbjct: 207 RAHREIKDIFYKAIQK------RRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGL 260 Query: 324 QLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED-LRNMPYLKACLK 382 LA T++ + W+ + L+R+ Q++ E ++V +N P D L+++ L C+K Sbjct: 261 LLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIK 320 Query: 383 ESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQ 442 E++RL P + R P + Y +P G + ++ V +D++ + F P+R+LQ Sbjct: 321 ETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQ 380 Query: 443 KEKKIN-PFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDN 490 FA++PFG G+ CIG A +Q+ +++ Y+ D Sbjct: 381 DNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDG 429 >4KPA-A nrPDB Length = 494 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 95/405 (23%), Positives = 176/405 (43%), Gaps = 31/405 (7%) Query: 94 GQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQ 153 G+IF+ + + +L S L++ ES + L + K RD + + Sbjct: 61 GEIFKFEAPGRVTRYLSSQRLIKEAC-DESRFDKNLS-QALKFVRDFAGDGLFTSWTHEK 118 Query: 154 EWQRVRS----AFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNK 209 W++ + +F ++ MK M +D + L ER++ DE +P+ ++ + Sbjct: 119 NWKKAHNILLPSFSQQAMKGYHAMMVDIAVQ--LVQKWERLN--ADEHIEVPE---DMTR 171 Query: 210 WSFESICLVLYEKRFGLLQKETEEEALT-FITAIKTMMSTFGKMMVTPVELHKRLNTKVW 268 + ++I L + RF ++ +T + A+ M+ + P + N + + Sbjct: 172 LTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQR--ANPDDPAYDENKRQF 229 Query: 269 QAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLC------DIYQQDHLSKKELYAAVTE 322 Q + + V I +R + S + D L D + L + + + Sbjct: 230 QEDIKVMNDL---VDKIIADR--KASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIIT 284 Query: 323 LQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLK 382 +A ETT+ L + LY L +NP ++ +E VL D P + ++ + Y+ L Sbjct: 285 FLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVD-PVPSYKQVKQLKYVGMVLN 343 Query: 383 ESMRLTPSVPFTTRTLDKPTVLG-EYALPKGT-VLTLNTQVLGSSEDNFEDSHKFRPERW 440 E++RL P+ P + + TVLG EY L KG ++ L Q+ +D +FRPER+ Sbjct: 344 EALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERF 403 Query: 441 LQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI 485 + I A PFG G+R CIG++ A + L L +++ +D Sbjct: 404 -ENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDF 447 >5E0E-A nrPDB Length = 463 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 94/420 (22%), Positives = 168/420 (40%), Gaps = 45/420 (10%) Query: 91 KKYGQIFRMKLGSFDSVHL-GSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMI 149 +KYG +F + LG V L G+ ++ EAL A R I A + YG++ Sbjct: 32 EKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI----AVVEPIFRGYGVVF 87 Query: 150 LEGQEWQRVRSAFQKKLMKPVEIMK--LDKKINEVLADFLERMDELCDERGRIPDLYSEL 207 G+ W+ +R F M+ + K ++++I E +E E +G D Sbjct: 88 ANGERWKALRR-FSLVTMRDFGMGKRSVEERIQEEARCLVE---EFRKSQGAPLDPTFLF 143 Query: 208 NKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKT-------MMSTFGKMMVTPVELH 260 + IC +++ +RF + F + + F + H Sbjct: 144 QCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFSGFLKYFPGTH 203 Query: 261 KRLNTKVWQAHTLAWDTIFKSV------------KPCIDNRLQRYSQQPGADFLCDIYQQ 308 ++++ + + D I +SV + ID L R ++ Q Sbjct: 204 RQISRNLQEI----LDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSN-------QH 252 Query: 309 DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRA 368 + L +V L A ET++ +L + + + P ++ +E+ V+ ++ P Sbjct: 253 TEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTL 312 Query: 369 EDLRNMPYLKACLKESMRLTPSVPFTT-RTLDKPTVLGEYALPKGT-VLTLNTQVLGSSE 426 ED MPY +A + E R + +P + K T+ Y LPK T V + + L + Sbjct: 313 EDRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQ 372 Query: 427 DNFEDSHKFRPERWLQKEKKINPF-AHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI 485 FE F P+ +L + A +PF IGKR+C+G +A +L L I+Q + + Sbjct: 373 -YFEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSL 431 >3S79-A nrPDB Length = 503 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 89/467 (19%), Positives = 197/467 (42%), Gaps = 70/467 (14%) Query: 56 TSLPGPTNWPLLGSLLE---IFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSP 112 +S+PGP +G L+ W G Y++ YG+ R+ + +++ + Sbjct: 45 SSIPGPGYCMGIGPLISHGRFLWMG----IGSACNYYNRVYGEFMRVWISGEETLIISKS 100 Query: 113 SLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQE-----------WQRVRSA 161 S + I Y GL + E W+ R Sbjct: 101 SSM-------------FHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPF 147 Query: 162 FQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYE 221 F K L P ++++ E L L+R++E+ +E G + D+ + L + ++L Sbjct: 148 FMKALSGP-GLVRMVTVCAESLKTHLDRLEEVTNESGYV-DVLTLLRR-------VMLDT 198 Query: 222 KRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKS 281 L+ +E A+ + I+ + +++ P K + +++ + + + + Sbjct: 199 SNTLFLRIPLDESAI--VVKIQGYFDAWQALLIKPDIFFKI--SWLYKKYEKSVKDLKDA 254 Query: 282 VKPCIDNRLQRYSQQPG----ADFLCDIY---QQDHLSKKELYAAVTELQLAAVETTANS 334 ++ I + +R S + DF ++ ++ L+++ + + E+ +AA +T + S Sbjct: 255 IEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVS 314 Query: 335 LMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFT 394 L ++L+ ++++P + +++E+Q+V+ + + +D++ + ++ + ESMR P V Sbjct: 315 LFFMLFLIAKHPNVEEAIIKEIQTVIGERDI-KIDDIQKLKVMENFIYESMRYQPVVDLV 373 Query: 395 TRTLDKPTVLGEYALPKGTVLTLNTQVLGS-------SEDNFEDSHKFRPERWLQKEKKI 447 R + V+ Y + KGT + LN + +E E+ K P R+ Q Sbjct: 374 MRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQ----- 428 Query: 448 NPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVE 494 PFG G R C G+ +A + + L +++++ + + VE Sbjct: 429 ------PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVE 469 >1WIY-A nrPDB Length = 389 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 51/177 (28%), Positives = 86/177 (48%), Gaps = 21/177 (11%) Query: 309 DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRA 368 HL ++ + L +A ET A++L W LS P Q+R+ + ++ Sbjct: 204 SHLPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRVAESEEAA--------- 254 Query: 369 EDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDN 428 A +E++RL P TR L++P +LGE LP+GT L L+ V + Sbjct: 255 ---------LAAFQEALRLYPPAWILTRRLERPLLLGEDRLPQGTTLVLSPYV--TQRLY 303 Query: 429 FEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI 485 F + F+PER+L E+ + PFG+G+R+C+GR A L+ + L +++ + Sbjct: 304 FPEGEAFQPERFL-AERGTPSGRYFPFGLGQRLCLGRDFALLEGPIVLRAFFRRFRL 359 >2W0A-A nrPDB Length = 455 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 41/177 (23%), Positives = 82/177 (46%), Gaps = 2/177 (1%) Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED 370 S E+ + A T++ + W L L R+ A ++ E+ + D ++ Sbjct: 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 Query: 371 LRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFE 430 LR +P L+ LKE++RL P + R + + + +G ++ + + ++F Sbjct: 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 Query: 431 DSHKFRPERWLQ--KEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI 485 D H F P R+ Q +E +N + +PFG G+ C+G A +Q+ ++++Y+ Sbjct: 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEF 417 >3L4D-A nrPDB Length = 453 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 51/209 (24%), Positives = 92/209 (44%), Gaps = 9/209 (4%) Query: 299 ADFLCDIYQQD-HLSKKELYAAVTELQLAAVETTANSLMWILYNL--SRNPQAQRRLLQE 355 A L +Y+ +S+ E+ + A T+ + W L +L RN + +L QE Sbjct: 235 AGLLGAVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQE 294 Query: 356 VQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVL 415 + Q + MP+ + C +ES+R P + R + KP +G+Y +P+G ++ Sbjct: 295 IDEF--PAQLNYDNVMEEMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDII 352 Query: 416 TLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLA 475 + + E+ F + ++ PER + K+ A FG G CIG + LQ+ Sbjct: 353 ACSPLLSHQDEEAFPNPREWNPERNM----KLVDGAFCGFGAGVHKCIGEKFGLLQVKTV 408 Query: 476 LCWIIQKYDIVATDNEPVEMLHLGILVPS 504 L +++ YD P H ++ P+ Sbjct: 409 LATVLRDYDFELLGPLPEPNYHTMVVGPT 437 >5FSA-A nrPDB Length = 490 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 55/228 (24%), Positives = 93/228 (40%), Gaps = 42/228 (18%) Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLP----DNQTP 366 ++ +E+ + + + T+A++ W L +L P Q + QEV +L D Sbjct: 250 MTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDL 309 Query: 367 RAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGE--YALPKGTVLTLNTQVLGS 424 EDL+ +P + +KE++R+ + R + P + E Y +PKG + ++ + Sbjct: 310 TYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHT 369 Query: 425 SEDNFEDSHKFRPERWLQKEKKINPFA---------------------HLPFGIGKRMCI 463 SE F++ F P RW K N + +LPFG G+ CI Sbjct: 370 SERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCI 429 Query: 464 GRRLAELQLHLALC-------WIIQKYDI--------VATDNEPVEML 496 G + A +QL L W I Y + V EP E++ Sbjct: 430 GEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEII 477 >2X2N-A nrPDB Length = 475 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 46/200 (23%), Positives = 88/200 (44%), Gaps = 16/200 (8%) Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNL-----SRNPQAQRRLLQEVQSVLPDNQT 365 +S E+ + A T++ + W + +L ++ +A R+ ++E + L N Sbjct: 262 MSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFPAQLNYNNV 321 Query: 366 PRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSS 425 + MP+ + C +ES+R P + R + +G Y +PKG ++ + + Sbjct: 322 -----MDEMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLLSHHD 376 Query: 426 EDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI 485 E+ F + ++ PER + E A + FG G CIG++ LQ+ L + YD Sbjct: 377 EEAFPEPRRWDPERDEKVEG-----AFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDF 431 Query: 486 -VATDNEPVEMLHLGILVPS 504 + D P H ++ P+ Sbjct: 432 QLLRDEVPDPDYHTMVVGPT 451 >2WX2-A nrPDB Length = 473 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 46/197 (23%), Positives = 89/197 (45%), Gaps = 10/197 (5%) Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNL--SRNPQAQRRLLQEVQSVLPDNQTPRA 368 +S E+ + A T+ + W + +L +N + +L +E+ Q Sbjct: 262 MSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEF--PAQLNYD 319 Query: 369 EDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDN 428 + MP+ + C++ES+R P + R + +G Y +PKG ++ + + E+ Sbjct: 320 NVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEA 379 Query: 429 FEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI-VA 487 F + + PER ++K++ A + FG G CIG++ A LQ+ L ++YD + Sbjct: 380 FPNPRLWDPER----DEKVDG-AFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLL 434 Query: 488 TDNEPVEMLHLGILVPS 504 D P H ++ P+ Sbjct: 435 RDEVPDPDYHTMVVGPT 451 >1F4U-A nrPDB Length = 368 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 56/198 (28%), Positives = 91/198 (45%), Gaps = 22/198 (11%) Query: 306 YQQDHL-SKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDN- 363 Y +DHL S E+ + V L+ +E IL ++ N + V N Sbjct: 174 YVKDHLNSGTEVVSRVVNSNLSDIEKLG---YIILLLIAGNETTTNLISNSVIDFTRFNL 230 Query: 364 -QTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVL 422 Q R E+L YLKA ++E++R +P V T R + LG+ + +G + + Sbjct: 231 WQRIREENL----YLKA-IEEALRYSPPVMRTVRKTKERVKLGDQTIEEGEYVRVWIASA 285 Query: 423 GSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQK 482 E+ F D KF P+R NP HL FG G +C+G LA L+ +A+ ++ Sbjct: 286 NRDEEVFHDGEKFIPDR--------NPNPHLSFGSGIHLCLGAPLARLEARIAIEEFSKR 337 Query: 483 Y---DIVATDNEPVEMLH 497 + +I+ T+ P E+L+ Sbjct: 338 FRHIEILDTEKVPNEVLN 355 >6CR2-A nrPDB Length = 477 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 43/179 (24%), Positives = 79/179 (44%), Gaps = 20/179 (11%) Query: 314 KELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED-LR 372 +E+ + L +A +++++ WI+ L+ P L QE VL + P D L+ Sbjct: 249 EEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLGSDLPPLTYDNLQ 308 Query: 373 NMPYLKACLKESMRLTPSVPFTTRTLDKPTVLG--EYALPKGTVLTLNTQVLGSSEDNFE 430 + +KE++RL + R + P + Y +P + + V SE++F Sbjct: 309 KLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFP 368 Query: 431 DSHKFRPERW-------LQKEKKIN----------PFAHLPFGIGKRMCIGRRLAELQL 472 + ++ P RW + ++K++ +LPFG G+ CIG + A LQL Sbjct: 369 NPLEWNPHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQL 427 >4WMZ-A nrPDB Length = 539 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 43/191 (22%), Positives = 79/191 (41%), Gaps = 20/191 (10%) Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED 370 ++ +E+ + + + T+A + WIL +L+ P Q+ L +E VL + D Sbjct: 299 MTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYD 358 Query: 371 L-RNMPYLKACLKESMRLTPSVPFTTRTLDKPTVL--GEYALPKGTVLTLNTQVLGSSED 427 L + MP L +KE++R+ + R + K + Y +P G + ++ ++ Sbjct: 359 LLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDE 418 Query: 428 NFEDSHKFRPERWLQKEKKINPFA-----------------HLPFGIGKRMCIGRRLAEL 470 F ++H+F RW +LPFG G+ CIG A Sbjct: 419 YFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYC 478 Query: 471 QLHLALCWIIQ 481 QL + + I+ Sbjct: 479 QLGVLMSIFIR 489 >3SN5-A nrPDB Length = 491 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 50/217 (23%), Positives = 97/217 (44%), Gaps = 31/217 (14%) Query: 326 AAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPD-NQTPRAE---------DLRNMP 375 A+ T + W L+ + RNP+A + +EV+ L + Q E +L ++P Sbjct: 268 ASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLP 327 Query: 376 YLKACLKESMRLTPSVPFTTRTLDKPTVL----GEYALPKGTVLTLNTQVLGSSEDNFED 431 L + +KES+RL+ S RT + L G Y + K ++ L Q++ + + D Sbjct: 328 VLDSIIKESLRLS-SASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPD 386 Query: 432 SHKFRPERWLQKEKKINP----------FAHLPFGIGKRMCIGRRLAELQLHLALCWIIQ 481 F+ +R+L + K + ++PFG G +C GR A ++ L ++ Sbjct: 387 PLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLS 446 Query: 482 KYDIVATDNE----PVEM--LHLGILVPSRELPIAFR 512 +++ + + P++ LGIL P ++ ++ Sbjct: 447 YFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYK 483 >4TRI-A nrPDB Length = 407 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 39/142 (27%), Positives = 62/142 (43%), Gaps = 9/142 (6%) Query: 373 NMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDS 432 ++ L ++E +R T V RTL TV L G + L + E F D Sbjct: 262 DVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDP 321 Query: 433 HKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKY-DIVATDNE 491 FR +R NP +H+ FG G C+G +LA L+L L ++++ D+ D+ Sbjct: 322 DNFRIDR--------NPNSHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDA 373 Query: 492 PVEMLHLGILVPSRELPIAFRP 513 PV + + +P+ F P Sbjct: 374 PVPLRPANFVSGPESMPVVFTP 395 >3NC3-A nrPDB Length = 441 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 49/194 (25%), Positives = 80/194 (41%), Gaps = 26/194 (13%) Query: 296 QPGADFLCDI----YQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRR 351 PG+D + + Y+ LS K++ A + + LAA E +L ++Y+L NP Sbjct: 235 NPGSDLISILCTSEYEGMALSDKDILALILNVLLAATEPADKTLALMIYHLLNNP----- 289 Query: 352 LLQEVQSVLPDNQ-TPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALP 410 +++ VL D PRA + E++R P V R L + TV+G + Sbjct: 290 --EQMNDVLADRSLVPRA------------IAETLRYKPPVQLIPRQLSQDTVVGGMEIK 335 Query: 411 KGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFA--HLPFGIGKRMCIGRRLA 468 K T++ + FE F R K A HL FG G C+G A Sbjct: 336 KDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIKSAFSGAARHLAFGSGIHNCVGTAFA 395 Query: 469 ELQLHLALCWIIQK 482 + ++ + ++ K Sbjct: 396 KNEIEIVANIVLDK 409 >5JLC-A nrPDB Length = 515 Score = 55.1 bits (131), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 45/192 (23%), Positives = 79/192 (41%), Gaps = 21/192 (10%) Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLP-DNQTPRAE 369 ++ +E+ + + + T+A + W L +L+ P Q L QE VL D + + Sbjct: 281 MTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQEQMRVLNNDTKELTYD 340 Query: 370 DLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVL--GEYALPKGTVLTLNTQVLGSSED 427 DL+NMP L +KE++RL + R + + + Y +P+ + ++ E+ Sbjct: 341 DLQNMPLLNQMIKETLRLHHPLHSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEE 400 Query: 428 NFEDSHKFRPERW------------------LQKEKKINPFAHLPFGIGKRMCIGRRLAE 469 F ++F RW K +LPFG G+ CIG A Sbjct: 401 FFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAY 460 Query: 470 LQLHLALCWIIQ 481 QL + + I+ Sbjct: 461 CQLGVLMSIFIR 472 >2WIO-A nrPDB Length = 431 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 44/145 (30%), Positives = 69/145 (47%), Gaps = 14/145 (9%) Query: 368 AEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSED 427 AED +P A ++E +R P P RT K T + +P ++ NT VL ++ D Sbjct: 288 AEDPGRIP---AIVEEVLRYRPPFPQMQRTTTKATEVAGVPIPADVMV--NTWVLSANRD 342 Query: 428 N--FEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI 485 + +D +F P R K A L FG G C+G LA L+ +AL II ++ Sbjct: 343 SDAHDDPDRFDPSR------KSGGAAQLSFGHGVHFCLGAPLARLENRVALEEIIARFGR 396 Query: 486 VATDNEPVEMLHL-GILVPSRELPI 509 + D + + H I++ +R LP+ Sbjct: 397 LTVDRDDERLRHFEQIVLGTRHLPV 421 >4RM4-A nrPDB Length = 396 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 43/176 (24%), Positives = 72/176 (40%), Gaps = 28/176 (15%) Query: 309 DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRA 368 + LS +EL T L +A ETT N + +Y++ P Sbjct: 222 EKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVY------------------- 262 Query: 369 EDLRNMPYL-KACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSED 427 E+LR+ P L ++E++R P R + T +G + + +G ++ E Sbjct: 263 EELRSHPELMPQAVEEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEA 322 Query: 428 NFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKY 483 F+ H F R +P H+ FG G C+G LA L+ ++AL +I + Sbjct: 323 KFDRPHMFDIRR--------HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAF 370 >6HQW-A nrPDB Length = 445 Score = 51.6 bits (122), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 48/188 (25%), Positives = 75/188 (39%), Gaps = 28/188 (14%) Query: 292 RYSQQPGADFLCDIYQQ---DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQA 348 R P D + + +H+S +E + L + +TT N++ I++ L + P Sbjct: 246 RMQAPPSGDLISMMIHSEAMNHMSPQEFMGNLVLLIVGGNDTTRNTMSGIVHALDKFPD- 304 Query: 349 QRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYA 408 QR LL+ S++P+ ++E +R + RT T L Sbjct: 305 QRELLERDASLIPN-----------------AVQECIRYVTPLAHMRRTATADTELFGNQ 347 Query: 409 LPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLA 468 + G + L E FE+ K +R N HL FG G C+G RLA Sbjct: 348 IKAGEKVILWYISANRDETVFENPDKLMVDR-------PNARRHLSFGHGIHRCVGARLA 400 Query: 469 ELQLHLAL 476 ELQL + L Sbjct: 401 ELQLRILL 408 >5CJE-A nrPDB Length = 393 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 57/230 (24%), Positives = 89/230 (38%), Gaps = 35/230 (15%) Query: 269 QAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQ-----QDHLSKKELYAAVTEL 323 A A++ + + ID++ S P D L D+ + D LS +EL A L Sbjct: 174 DAELAAYERLAAYLDELIDDK---RSTAPADDLLGDLIRTRAEDDDRLSGEELRAMAFIL 230 Query: 324 QLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKE 383 +A ETT N + ++ L +P L RA +M L ++E Sbjct: 231 LVAGHETTVNLITNGVHTLLTHPDQLAAL--------------RA----DMTLLDGAVEE 272 Query: 384 SMRL-TPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQ 442 +R P T R + +G A+ +G + + G D H F R Sbjct: 273 VLRFEGPVETATYRYAAESMEIGGTAIAEGDPVMIGLDAAGRDPARHPDPHVFDIHR--- 329 Query: 443 KEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEP 492 P HL FG G C+G LA L+ +AL ++++ +A D P Sbjct: 330 -----APQGHLAFGHGIHYCLGAPLARLEARVALRSLLERCPDLALDGPP 374 >6DCD-A nrPDB Length = 424 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 46/177 (25%), Positives = 77/177 (43%), Gaps = 25/177 (14%) Query: 315 ELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNM 374 ++ + T L A ETTA L + L P QRRL +E +S++P+ Sbjct: 241 DVVRSATFLFAAGQETTAKLLTAAMRVLGDRPDIQRRL-RENRSLIPN------------ 287 Query: 375 PYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHK 434 ++ES+R+ V +R K T +G + GTV+ + FED H+ Sbjct: 288 -----FIEESLRMDSPVKSDSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHE 342 Query: 435 FRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNE 491 FR +R +E H+ F G C G LA ++ ++L I+ + +A + + Sbjct: 343 FRLDRPNVRE-------HMAFARGVHSCPGGPLARVEGRVSLERILDRMLDIAINED 392 >4WPZ-A nrPDB Length = 397 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 51/193 (26%), Positives = 78/193 (40%), Gaps = 28/193 (14%) Query: 295 QQPGADFLCDIYQ----QDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQR 350 + P D + ++ L+++E+ A + A ETTAN + L L NP+ Sbjct: 197 ENPADDLISELIAISDGDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLHNPEELD 256 Query: 351 RLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVL-GEYAL 409 +L +++ P+A D E +R VP TT P + E L Sbjct: 257 KLRDNREAI------PKAVD------------ELLRF---VPLTTTGGIIPRLTTAEVEL 295 Query: 410 PKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAE 469 G VL VL + D F L ++ NP HL FG G C+G +LA Sbjct: 296 SGGQVLPAGAVVLPAVATANRDPEVFEDGERLNVTRENNP--HLAFGAGIHHCLGAQLAR 353 Query: 470 LQLHLALCWIIQK 482 ++L AL I+ + Sbjct: 354 IELQEALGAILDR 366 >3P3Z-A nrPDB Length = 416 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 53/226 (23%), Positives = 94/226 (41%), Gaps = 30/226 (13%) Query: 290 LQRYSQQPGADFLCDIYQQDH---LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNP 346 +++ +PG D DI + H L EL V + +A ETT + L +Y+ +++P Sbjct: 214 IEKRKVEPGDDLTSDIVRAFHDGVLDDYELRTLVATVLVAGYETTNHQLALAMYDFAQHP 273 Query: 347 QAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDKPTVLG 405 Q ++E + P ++E +R +P++P T TR + + Sbjct: 274 D-QWMKIKENPELAPQ-----------------AVEEVLRWSPTLPVTATRVAAEDFEVN 315 Query: 406 EYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGR 465 +P GT + + V F D+ +F + +++E + FG G C+G Sbjct: 316 GVRIPTGTPVFMCAHVAHRDPRVFADADRF--DITVKREAP-----SIAFGGGPHFCLGT 368 Query: 466 RLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAF 511 LA L+L A+ + + D E LG+ P LP+ F Sbjct: 369 ALARLELTEAVAALATRLDPPQIAGEITWRHELGVAGPD-ALPLRF 413 >3R9C-A nrPDB Length = 418 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 48/215 (22%), Positives = 77/215 (35%), Gaps = 34/215 (15%) Query: 282 VKPCIDNRLQRYSQQPGADFLCDIY----QQDHLSKKELYAAVTELQLAAVETTANSLMW 337 ++ ID R + PG D + + D L++ E+ A L +A ETT N + Sbjct: 212 LRALIDER----RRTPGEDLMSGLVAVEESGDQLTEDEIIATCNLLLIAGHETTVNLIAN 267 Query: 338 ILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRT 397 + R P L + A ++E+MR P V +R Sbjct: 268 AALAMLRTPGQWAALAADGSRA------------------SAVIEETMRYDPPVQLVSRY 309 Query: 398 LDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGI 457 +G + +PKG + L +F P+R + HL FG Sbjct: 310 AGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPDRAQIR--------HLGFGK 361 Query: 458 GKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEP 492 G C+G LA L+ +AL + ++ EP Sbjct: 362 GAHFCLGAPLARLEATVALPALAARFPEARLSGEP 396 >2IAG-A nrPDB Length = 482 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 61/232 (26%), Positives = 102/232 (43%), Gaps = 33/232 (14%) Query: 314 KELYAAVTELQLAAVETTAN-SLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED-- 370 +E+ A LQL A + + W+L L +NP+A + E++S+L + P ++ Sbjct: 248 EEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTT 307 Query: 371 -----LRNMPYLKACLKESMRLTPSVPFTTR----TLDKPTVLG-EYALPKGTVLTLNTQ 420 L + P L + L ES+RLT + PF TR L P G E+ L +G L L Sbjct: 308 LPQKVLDSTPVLDSVLSESLRLT-AAPFITREVVVDLAMPMADGREFNLRRGDRLLL-FP 365 Query: 421 VLGSSEDN--FEDSHKFRPERWLQ----------KEKKINPFAHLPFGIGKRMCIGRRLA 468 L D + D F+ R+L K+ K ++P+G G C+GR A Sbjct: 366 FLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYA 425 Query: 469 --ELQLHLALCWIIQKYDIVATDNEPVEM----LHLGILVPSRELPIAFRPR 514 ++ + L + +++ D E E G++ P ++P+ +R R Sbjct: 426 VNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 477 >3MGX-A nrPDB Length = 415 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 48/228 (21%), Positives = 86/228 (37%), Gaps = 27/228 (11%) Query: 287 DNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNP 346 D + ++PG D + + D L+ ++ + + ETT +++ ++ L+ P Sbjct: 215 DELITARRKEPGDDLVSTLVTDDDLTIDDVLLNCDNVLIGGNETTRHAITGAVHALATVP 274 Query: 347 QAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGE 406 LL ++ D T ++E +R T R + Sbjct: 275 G----LLTALRDGSADVDT--------------VVEEVLRWTSPAMHVLRVTTADVTING 316 Query: 407 YALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRR 466 LP GT + F+D F P R P H+ FG G C+G Sbjct: 317 RDLPSGTPVVAWLPAANRDPAEFDDPDTFLPGR--------KPNRHITFGHGMHHCLGSA 368 Query: 467 LAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRPR 514 LA ++L + L + ++ V + EP + + ++ RELP+ F R Sbjct: 369 LARIELSVVLRVLAERVSRVDLEREPAWLRAI-VVQGYRELPVRFTGR 415 >1Z8P-A nrPDB Length = 404 Score = 48.9 bits (115), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 51/209 (24%), Positives = 86/209 (41%), Gaps = 31/209 (14%) Query: 280 KSVKPCIDNRLQRYSQQPGADFLCDIYQ-QD----HLSKKELYAAVTELQLAAVETTANS 334 + V I + ++R +PG D L + + QD LS EL + L LA E++ + Sbjct: 190 REVVNFILDLVERRRTEPGDDLLSALIRVQDDDDGRLSADELTSIALVLLLAGFESSVSL 249 Query: 335 LMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFT 394 + Y L +P Q L++ S LP+ ++E +R T Sbjct: 250 IGIGTYLLLTHPD-QLALVRRDPSALPN-----------------AVEEILRYIAPPETT 291 Query: 395 TRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLP 454 TR + +G A+P+ + + + F D H+F R + HL Sbjct: 292 TRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRFDVTR--------DTRGHLS 343 Query: 455 FGIGKRMCIGRRLAELQLHLALCWIIQKY 483 FG G C+GR LA+L+ +AL + ++ Sbjct: 344 FGQGIHFCMGRPLAKLEGEVALRALFGRF 372 >1GWI-A nrPDB Length = 411 Score = 48.9 bits (115), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 51/216 (23%), Positives = 89/216 (41%), Gaps = 41/216 (18%) Query: 297 PGADFLCDIYQQ----DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRL 352 PG D + Q DHL+ E+ + + + A ETT + ++ + NLS +P+ QR L Sbjct: 209 PGDDLTSALIQASENGDHLTDAEIVSTLQLMVAAGHETTISLIVNAVVNLSTHPE-QRAL 267 Query: 353 LQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRL-TPSVPFTTRTLDKPTVLGEYALPK 411 + L A ++E++R TP+ R + +G+ +P Sbjct: 268 V-----------------LSGEAEWSAVVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPA 310 Query: 412 GTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQ 471 G L ++ LG E +H +R+ N H+ FG G +C G L+ ++ Sbjct: 311 GDALIVSYGALGRD----ERAHGPTADRFDLTRTSGN--RHISFGHGPHVCPGAALSRME 364 Query: 472 LHLALCWIIQKYDIVATDNEPVEMLHLGILVPSREL 507 +AL + ++ HL + VP+ EL Sbjct: 365 AGVALPALYARFP------------HLDLAVPAAEL 388 >2XKR-A nrPDB Length = 398 Score = 48.5 bits (114), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 56/207 (27%), Positives = 83/207 (40%), Gaps = 28/207 (13%) Query: 309 DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRA 368 + LS EL + + ETT ++L L RN + Q LLQ S+LP Sbjct: 213 ERLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRN-RDQWDLLQRDPSLLP------- 264 Query: 369 EDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDN 428 ++E +R T V R L T AL G + L + E Sbjct: 265 ----------GAIEEMLRWTAPVKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAV 314 Query: 429 FEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKY-DIVA 487 F + KF +R NP +HL FG G C+G +LA L+L L ++++ D+ Sbjct: 315 FCEPEKFDVQR--------NPNSHLAFGFGTHFCLGNQLARLELSLMTERVLRRLPDLRL 366 Query: 488 TDNEPVEMLHLGILVPSRE-LPIAFRP 513 ++ V L V E +P+ F P Sbjct: 367 VADDSVLPLRPANFVSGLESMPVVFTP 393 >5OFQ-A nrPDB Length = 409 Score = 48.1 bits (113), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 47/203 (23%), Positives = 85/203 (41%), Gaps = 26/203 (12%) Query: 309 DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRA 368 +HL+++E+ L +A ETT N + R + ++V D Q Sbjct: 224 EHLTEEEVLGFCILLLVAGNETTTNLIT----------NGVRYMTEDV-----DVQNEVR 268 Query: 369 EDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDN 428 D+ +P L ++E++R P + R + LGE + +G QV+ + Sbjct: 269 RDISLVPNL---VEETLRYYPPIQAIGRIAAEDVELGECKIKRGQ------QVISWAASA 319 Query: 429 FEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVAT 488 DS KF +K NP H+ FG G C+G LA ++ +A +++K Sbjct: 320 NRDSAKFEWPDTFVVHRKTNP--HVSFGFGIHFCLGAPLARMEGKIAFTKLLEKGGFSKV 377 Query: 489 DNEPVEMLHLGILVPSRELPIAF 511 N+ ++ + + ++ IAF Sbjct: 378 QNQSLKPIDSPFVFGVKKYEIAF 400 >4Z5P-A nrPDB Length = 400 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 52/207 (25%), Positives = 90/207 (43%), Gaps = 26/207 (12%) Query: 307 QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTP 366 D L++ EL L +A ET+A+ L ++Y L + + Q LL+E +LP Sbjct: 218 DDDRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTH-EDQLSLLREQPELLP----- 271 Query: 367 RAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSE 426 ++E +R VP + L + L GTV V+ ++ Sbjct: 272 ------------RAVEELLRF---VPLGNGVGNARIALEDVELSGGTVRA-GEGVVAAAV 315 Query: 427 DNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI- 485 + D F L ++ NP HL FG G C+G +LA ++L +A+ +++++ Sbjct: 316 NANRDPRAFDDPDRLDITREKNP--HLAFGHGAHYCLGAQLARMELRVAIGGLLERFPGL 373 Query: 486 -VATDNEPVEMLHLGILVPSRELPIAF 511 +A + VE G+ + LPIA+ Sbjct: 374 RLAVPADQVEWKTGGLFRGPQRLPIAW 400 >3RWL-A nrPDB Length = 426 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 47/205 (22%), Positives = 82/205 (40%), Gaps = 28/205 (13%) Query: 291 QRYSQQPGADFLCDIYQQ---DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQ 347 +R ++ PG D + + +++ +E V L + +TT NS+ + L +NP Sbjct: 227 ERVNKDPGNDLISMLAHSPATRNMTPEEYLGNVLLLIVGGNDTTRNSMTGGVLALHKNPD 286 Query: 348 AQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEY 407 +L N ++ + E +R + RT + LG Sbjct: 287 QFAKLKA------------------NPALVETMVPEIIRWQTPLAHMRRTAIADSELGGK 328 Query: 408 ALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRL 467 + KG + V+ N +D RPE ++ + P HL FG G C+G RL Sbjct: 329 TIRKG-----DKVVMWYYSGNRDDEVIDRPEEFIIDRPR--PRQHLSFGFGIHRCVGNRL 381 Query: 468 AELQLHLALCWIIQKYDIVATDNEP 492 AE+QL + I+ ++ + EP Sbjct: 382 AEMQLRILWEEILTRFSRIEVMAEP 406 >6HQG-A nrPDB Length = 425 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 55/251 (21%), Positives = 103/251 (41%), Gaps = 38/251 (15%) Query: 236 LTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQ 295 LTF + + T G + T E H+ L + T+F+ V + +R + Sbjct: 179 LTFWSDVATSAPESGILGTTDPEEHENLRRQ----------TLFECVDYFMRLWNERVNA 228 Query: 296 QPGADFLCDIYQQD---HLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRL 352 P D + + + ++ + E + L + +TT N++ + L +NP Q R Sbjct: 229 PPKPDLISMLAHGESTKNMDRMEYLGNLILLIVGGNDTTRNTISGSVLALHQNPD-QDRK 287 Query: 353 LQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKG 412 L+E ++P A + E++R + + R + LG + +G Sbjct: 288 LRENPGLIP-----------------AMVSETIRWQTPLAYMRRRAKRDFELGGKTIREG 330 Query: 413 TVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQL 472 + + V G+ ++ D RP + + ++ HL FG G C+G RLAELQL Sbjct: 331 DKVAM-WYVSGNRDEEVID----RPNDYWIERPRVR--QHLSFGFGVHRCVGNRLAELQL 383 Query: 473 HLALCWIIQKY 483 + I+ ++ Sbjct: 384 KIIWEEILARF 394 >3B98-A nrPDB Length = 475 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 55/230 (23%), Positives = 97/230 (42%), Gaps = 27/230 (11%) Query: 308 QDHLSKKELYAAVTELQLAAVETTAN-SLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTP 366 QD E+ LQL + A + W++ L +P+A R + +E+Q Sbjct: 245 QDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQG---GKHLR 301 Query: 367 RAEDLRNMPYLKACLKESMRLTPSVPFTTR-TLDKPTVLG---EYALPKGTVLT------ 416 E +N P + L E++RLT + T T DK L EY L +G L Sbjct: 302 LEERQKNTPVFDSVLWETLRLTAAALITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFIS 361 Query: 417 --LNTQVLGSSE----DNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAEL 470 ++ Q+ E D F ++ + + + + ++ + +P+G +C GR A Sbjct: 362 PQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVK-YPSVPWGTEDNLCPGRHFAVH 420 Query: 471 QLHLALCWIIQKYDIVATD-NEPVEMLH-----LGILVPSRELPIAFRPR 514 + + I+ ++D+ D N V ++ GIL P+ +L I +R R Sbjct: 421 AIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDLEIRYRIR 470 >6A7J-A nrPDB Length = 411 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 42/200 (21%), Positives = 87/200 (43%), Gaps = 32/200 (16%) Query: 290 LQRYSQQPGADFLCDIY----QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRN 345 ++ PG D + DHL+ +E+ + + A ETT + ++ ++ L+ + Sbjct: 200 VEEKKANPGDDLTSALIAASEDGDHLTDEEILNTLQLIIAAGHETTISLIVNVVEALAIH 259 Query: 346 PQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRL-TPSVPFTTRTLDKPTVL 404 P+ ++++L +P+ + ++E++R TP+ R + + Sbjct: 260 PEQRKKVLS-----------------GEIPW-EGVIEETLRWNTPTSHVLIRFATEDIEV 301 Query: 405 GEYALPKGTVLTLNTQVLGSSEDNFE-DSHKFRPERWLQKEKKINPFAHLPFGIGKRMCI 463 G+ LPKG L ++ LG E+ + + F R P H+ FG G +C Sbjct: 302 GDKVLPKGEGLVVSFGALGRDEEQYGPTAGDFDATR--------TPNRHIAFGHGPHVCP 353 Query: 464 GRRLAELQLHLALCWIIQKY 483 G L+ L+ +AL + +++ Sbjct: 354 GAALSRLEAGIALPALYERF 373 >5GWE-A nrPDB Length = 405 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 43/162 (26%), Positives = 65/162 (40%), Gaps = 8/162 (4%) Query: 316 LYAAVTELQLAAVETTANSLMWILYNL-SRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNM 374 L A + Q E T + + +LY+L + L+ VL D+ L N Sbjct: 213 LTADLVRAQQEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILENP 272 Query: 375 PYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHK 434 + A + E +R + S+ R K T +G A+ +G + L E FE+ + Sbjct: 273 KLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEE 332 Query: 435 FRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLAL 476 F R N HL FG G C+G LA+LQ + L Sbjct: 333 FDISR-------ANAREHLSFGFGIHYCLGNMLAKLQAKICL 367 >5XJN-A nrPDB Length = 455 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 43/162 (26%), Positives = 66/162 (40%), Gaps = 8/162 (4%) Query: 316 LYAAVTELQLAAVETTANSLMWILYNL-SRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNM 374 L A + Q E T + + +LY+L + L+ VL D+ L N Sbjct: 263 LTADLVRAQQEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILENP 322 Query: 375 PYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHK 434 + A + E +R + S+ R K T +G A+ +G + L E FE+ + Sbjct: 323 KLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEE 382 Query: 435 FRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLAL 476 F R +E HL FG G C+G LA+LQ + L Sbjct: 383 FDISRANARE-------HLSFGFGIHYCLGNMLAKLQAKICL 417 >2Y5N-A nrPDB Length = 417 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 47/201 (23%), Positives = 81/201 (40%), Gaps = 36/201 (17%) Query: 290 LQRYSQQPGADFLCDIYQ----QDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRN 345 + R ++P D + + Q QD LS++EL L +A E+T + +Y L Sbjct: 214 IDRRRKEPTDDLVSALVQARDQQDSLSEQELLDLAIGLLVAGYESTTTQIADFVYLLMTR 273 Query: 346 PQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLG 405 P+ +R+LL + + + ++E R P L T Sbjct: 274 PELRRQLLDRPE------------------LIPSAVEELTRWVP--------LGVGTAFP 307 Query: 406 EYALP----KGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRM 461 YA+ +G + VL S+ D +F + ++ P HL FG G Sbjct: 308 RYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDR--TPNQHLGFGHGVHH 365 Query: 462 CIGRRLAELQLHLALCWIIQK 482 C+G LA ++L +AL ++Q+ Sbjct: 366 CLGAPLARVELQVALEVLLQR 386 >5LIE-A nrPDB Length = 414 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 49/184 (26%), Positives = 72/184 (39%), Gaps = 27/184 (14%) Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED 370 LS ELY L A ETT NS+ L L+ NP LQ ++S Sbjct: 238 LSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQ----LQTLRS------------ 281 Query: 371 LRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFE 430 + L ++E +R T P RT + LG + G + + F+ Sbjct: 282 --DFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFD 339 Query: 431 DSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDN 490 + +F +K NP HL FG G C+G LA L+L + ++ ++ V Sbjct: 340 RADEF------DITRKPNP--HLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRV-V 390 Query: 491 EPVE 494 EP E Sbjct: 391 EPAE 394 >1UE8-A nrPDB Length = 367 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 31/115 (26%), Positives = 55/115 (47%), Gaps = 9/115 (7%) Query: 371 LRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFE 430 +R LKA ++E++R +P V T R + + + + +G ++ + E+ F+ Sbjct: 235 VREKGALKA-VEEALRFSPPVMRTIRVTKEKVKIRDQVIDEGELVRVWIASANRDEEVFK 293 Query: 431 DSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI 485 D F P+R P HL FG G +C+G LA L+ +AL +K+ + Sbjct: 294 DPDSFIPDR--------TPNPHLSFGSGIHLCLGAPLARLEARIALEEFAKKFRV 340 >2WM5-A nrPDB Length = 435 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 48/188 (25%), Positives = 77/188 (40%), Gaps = 28/188 (14%) Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED 370 LS +E+ + L +A ETT N++ + LSR P+ + R + + P Sbjct: 259 LSSREIASFFILLVVAGNETTRNAITHGVLALSRYPEQRDRWWSDFDGLAP--------- 309 Query: 371 LRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFE 430 ++E +R V + RTL + L + G ++L E F Sbjct: 310 --------TAVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFA 361 Query: 431 DSHKFRPERWLQKEKKINPFAHLPF-GIGKRMCIGRRLAELQLHLALCWIIQKY-DIVAT 488 D F R NP HL F G G C+G LA ++ +A + ++ D+VAT Sbjct: 362 DPWTFDLAR--------NPNPHLGFGGGGAHFCLGANLARREIRVAFDELRRQMPDVVAT 413 Query: 489 DNEPVEML 496 + EP +L Sbjct: 414 E-EPARLL 420 >2VZM-A nrPDB Length = 436 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 51/207 (24%), Positives = 81/207 (39%), Gaps = 32/207 (15%) Query: 296 QPGADFLCDIYQQD-----HLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQR 350 Q G D L + + L+ +EL L +A ETT N + +Y L +P Sbjct: 228 QDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLA 287 Query: 351 RLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRL-TPSVPFTTRTLDKPTVLGEYAL 409 L RA +M L ++E +R P T R +P L + Sbjct: 288 AL--------------RA----DMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVI 329 Query: 410 PKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAE 469 P G + + + + F D H+F R + HL FG G CIG LA Sbjct: 330 PAGDTVLVVLADAHRTPERFPDPHRFDIRR--------DTAGHLAFGHGIHFCIGAPLAR 381 Query: 470 LQLHLALCWIIQKYDIVATDNEPVEML 496 L+ +A+ ++++ +A D P E++ Sbjct: 382 LEARIAVRALLERCPDLALDVSPGELV 408 >5FYF-A nrPDB Length = 470 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 48/205 (23%), Positives = 85/205 (41%), Gaps = 32/205 (15%) Query: 294 SQQPGADFLCDIYQQDHLSKK------ELYAAVTELQLAAVETTANSLMWILYNLSRNPQ 347 ++PG D L + Q + +K E +T L + +TT NS+ L ++ P+ Sbjct: 270 GEEPGFD-LISLLQSNKETKDLINRPMEFIGNLTLLIVGGNDTTRNSMSGGLVAMNEFPR 328 Query: 348 AQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEY 407 +L + E + NM + E +R + + R + LG Sbjct: 329 EFEKL------------KAKPELIPNM------VSEIIRWQTPLAYMRRIAKQDVELGGQ 370 Query: 408 ALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRL 467 + KG + + E F++ +F +R K+ + H+ FG G C+G RL Sbjct: 371 TIKKGDRVVMWYASGNRDERKFDNPDQFIIDR---KDAR----NHMSFGYGVHRCMGNRL 423 Query: 468 AELQLHLALCWIIQKYDIVATDNEP 492 AELQL + I++++D + EP Sbjct: 424 AELQLRILWEEILKRFDNIEVVEEP 448 >3TKT-A nrPDB Length = 450 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 34/121 (28%), Positives = 50/121 (41%), Gaps = 10/121 (8%) Query: 372 RNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFED 431 RN+ L ++E++R T V RT T L + G L LN F + Sbjct: 319 RNL--LPGIVEEAIRWTTPVQHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPE 376 Query: 432 SHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNE 491 KF P R + HL FG G C+G LA L++ + L ++ + D + E Sbjct: 377 PRKFDPTRPANR--------HLAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGE 428 Query: 492 P 492 P Sbjct: 429 P 429 >1CPT-A nrPDB Length = 428 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 45/203 (22%), Positives = 84/203 (41%), Gaps = 27/203 (13%) Query: 309 DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRA 368 +++ K + A + A +TT++S + LSRNP+ Q L + +++P Sbjct: 250 NYIDDKYINAYYVAIATAGHDTTSSSSGGAIIGLSRNPE-QLALAKSDPALIP------- 301 Query: 369 EDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDN 428 + E++R T V RT T + + +G + L+ E+ Sbjct: 302 ----------RLVDEAVRWTAPVKSFMRTALADTEVRGQNIKRGDRIMLSYPSANRDEEV 351 Query: 429 FEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVAT 488 F + +F R+ P HL FG G MC+G+ LA+L++ + ++ K V Sbjct: 352 FSNPDEFDITRF--------PNRHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLKSVEL 403 Query: 489 DNEPVEMLHLGILVPSRELPIAF 511 P ++ + + +PI F Sbjct: 404 SGPP-RLVATNFVGGPKNVPIRF 425 >6A7I-A nrPDB Length = 411 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 42/195 (21%), Positives = 83/195 (42%), Gaps = 34/195 (17%) Query: 296 QPGADFLCDIY----QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRR 351 PG D + DHL+ +E+ + + A ETT + ++ ++ L +P+ +++ Sbjct: 206 NPGDDLTSALIAASENGDHLTDEEIVNTLQLIIAAGHETTISLIVNVVEALQTHPEQRKK 265 Query: 352 LLQ-EVQSVLPDNQTPRAEDLRNMPYLKACLKESMRL-TPSVPFTTRTLDKPTVLGEYAL 409 +L E+ ++E++R TP+ R + +G+ L Sbjct: 266 VLNGEIG-------------------WDGVIEETLRWNTPTSHVLIRFATEDIEVGDKIL 306 Query: 410 PKGTVLTLNTQVLGSSEDNFE-DSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLA 468 PKG L ++ LG E+ + + +F R P H+ FG G +C G L+ Sbjct: 307 PKGEGLIISFGALGRDEEQYGPTAGEFDATR--------TPNRHIAFGHGPHVCPGAALS 358 Query: 469 ELQLHLALCWIIQKY 483 L+ +AL + +++ Sbjct: 359 RLEAGIALPALYERF 373 >5L1U-A nrPDB Length = 401 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 53/200 (26%), Positives = 83/200 (41%), Gaps = 31/200 (15%) Query: 279 FKSVKPCIDNRLQRYSQQPGADFLCD-IYQQDH-LSKKELYAAVTELQLAAVETTANSLM 336 F+ V + + R +PG D L + I ++D LS ++ + L ETT + Sbjct: 186 FQQVVDYMLELVARKRVEPGDDILSELIAEKDGALSDADIAHLGNAVLLFGYETTIVRID 245 Query: 337 WILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLT----PSVP 392 L RNP QR L E + P A ++E +RL S Sbjct: 246 LGTLLLLRNP-VQRAQLAEDPGLAP-----------------AAVEEILRLGVGGKGSNA 287 Query: 393 FTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAH 452 R +GE + G + L +G++ N++D + P+ L ++ P +H Sbjct: 288 LIPRYAHGDITVGETVIRTGDAVML---AIGAA--NYDD--RAFPDGGLFDLTRVRPRSH 340 Query: 453 LPFGIGKRMCIGRRLAELQL 472 L FG G R CIGR LA ++L Sbjct: 341 LAFGHGARHCIGRTLARIEL 360 >5Z9I-A nrPDB Length = 398 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 30/111 (27%), Positives = 47/111 (42%), Gaps = 8/111 (7%) Query: 379 ACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPE 438 A L+ESMR + R + + +PK +L + T E FE F Sbjct: 272 ALLEESMRYMSPICGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAG 331 Query: 439 RWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATD 489 R +P AHL FG G C+GR+LA ++ A+ ++ + + D Sbjct: 332 R--------SPNAHLGFGRGIHFCLGRQLARMESKAAVEILLDRLPTLRAD 374 >3WVS-A nrPDB Length = 401 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 45/191 (23%), Positives = 78/191 (40%), Gaps = 28/191 (14%) Query: 296 QPGADFLCDIYQ----QDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRR 351 QP D + + + QD L+++EL L +A ETTA+ + +Y L PQ +R Sbjct: 207 QPADDLISGMIEARDVQDKLTEQELLDHCIGLLIAGHETTASQIPSFVYALLDQPQHWKR 266 Query: 352 LLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPK 411 LL + + + + ++E R P + P E Sbjct: 267 LLDDPE------------------LIPSAVEELFRFVPLGSGSA----APRYAREDIEVG 304 Query: 412 GTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQ 471 GT++ VL + D +F ++ ++ N H+ FG G C+G LA L+ Sbjct: 305 GTLVRAGEPVLVALGAANRDGLRFEDPEEIKLDRPSN--HHIGFGHGIHHCLGAPLARLE 362 Query: 472 LHLALCWIIQK 482 L AL ++++ Sbjct: 363 LQEALRALLER 373 >5D3U-A nrPDB Length = 427 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 54/211 (25%), Positives = 77/211 (36%), Gaps = 34/211 (16%) Query: 308 QDHLSKKELYAAVTELQLAAVE----TTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDN 363 QD L++ V +L L + TT SL +RNP+ R L + V DN Sbjct: 245 QDGLTETTPEQTVHQLALVFIALFAPTTPGSLSSGTLAFARNPRQVERFLADQACV--DN 302 Query: 364 QTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLG 423 E +R S FT R K +G + G L L Sbjct: 303 TA----------------NEVLRYNASNQFTWRVAAKDVEMGGVRIEAGQTLALFLGSAN 346 Query: 424 SSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKY 483 + FE + F +R N HL FG G C+ +L LQL ++ ++ Sbjct: 347 RDANMFERPNDFDLDR-------PNSARHLSFGQGVHACLAAQLISLQLKWFYVALLNRF 399 Query: 484 DIVATDNEPV--EMLHLGILVPSRELPIAFR 512 + T EP+ E L L R LP++ R Sbjct: 400 PGIRTAGEPIWNENLEFRSL---RSLPLSLR 427 >4YZR-A nrPDB Length = 405 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 42/175 (24%), Positives = 72/175 (41%), Gaps = 29/175 (16%) Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED 370 LS+KELY+ + L +A +ETT N L LLQ E Sbjct: 226 LSEKELYSMLFLLVVAGLETTVNLL----------GSGTLALLQ---------HKKECEK 266 Query: 371 LRNMPYLKA-CLKESMRLT-PSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDN 428 L+ P + A ++E +R T P V R + +++ +G ++ + + Sbjct: 267 LKQQPEMIATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNF 326 Query: 429 FEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKY 483 FE+ R +P H+ FG G C+G LA L+ H+A +++++ Sbjct: 327 FENPEILNINR--------SPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRF 373 >5DQN-A nrPDB Length = 426 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 46/189 (24%), Positives = 68/189 (35%), Gaps = 33/189 (17%) Query: 296 QPGADFLCDIYQQD----HLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRR 351 P D + + + D LS E V L +A ETT NS+ + ++NP Sbjct: 217 NPTEDIVTKLIEADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFAQNPDQWEL 276 Query: 352 LLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPK 411 +E D E +R V RT + LG + K Sbjct: 277 YKKERPETAAD--------------------EIVRWATPVSAFQRTALEDVELGGVQIKK 316 Query: 412 GTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPF-GIGKRMCIGRRLAEL 470 G + ++ + E+ FED H F R +P H+ F G G CIG LA + Sbjct: 317 GQRVVMSYRSANFDEEVFEDPHTFNILR--------SPNPHVGFGGTGAHYCIGANLARM 368 Query: 471 QLHLALCWI 479 ++L I Sbjct: 369 TINLIFNAI 377 >5L94-A nrPDB Length = 410 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 43/192 (22%), Positives = 74/192 (38%), Gaps = 30/192 (15%) Query: 296 QPGADFLCDIYQQD----HLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRR 351 +PG D + + Q L+ +E+ L +A ETT N + +Y L + + R Sbjct: 208 RPGDDIISVLLQAKEEGKQLTDEEIVGFSILLLIAGNETTTNLISNTIYCLMEDKASFER 267 Query: 352 LLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPK 411 L +E + +LP + ++E +R V R + + L L Sbjct: 268 LKRE-KELLP-----------------SGIEEVLRYRSPVQALHRIVKEDVTLAGKKLKA 309 Query: 412 GTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQ 471 G + + FED F+ +R P H+ FG G C+G LA ++ Sbjct: 310 GEHVVPWMGSAHRDAEYFEDPEVFKIDR--------KPNVHMAFGRGIHFCLGAPLARIE 361 Query: 472 LHLALCWIIQKY 483 + L +I +Y Sbjct: 362 AKIMLAELIDRY 373 >4PWV-A nrPDB Length = 446 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/138 (24%), Positives = 57/138 (41%), Gaps = 11/138 (7%) Query: 377 LKACLKESMR-LTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKF 435 L++ +E +R TP++ F R + + G+ + G V+TL E+ F D + F Sbjct: 303 LESATEEVLRWATPAMHFGRRAVTDMELHGQ-VIAAGDVVTLWNNSANRDEEVFADPYAF 361 Query: 436 RPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEM 495 R +P H+ FG G C+G L ++H L + EP + Sbjct: 362 DLNR--------SPNKHITFGYGPHFCLGAYLGRAEVHALLDALRTYTTGFEITGEP-QR 412 Query: 496 LHLGILVPSRELPIAFRP 513 +H L LP+ +P Sbjct: 413 IHSNFLTGLSRLPVRIQP 430 >4XE3-A nrPDB Length = 407 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 44/180 (24%), Positives = 75/180 (41%), Gaps = 30/180 (16%) Query: 307 QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTP 366 DHL+K E+ L +A ET+ N + +++ LL E + Sbjct: 225 NDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVH----------LLLTERK--------- 265 Query: 367 RAEDLRNMPYL-KACLKESMRLTPSVPFTT--RTLDKPTVLGEYALPKGTVLTLNTQVLG 423 R E L P L A ++E +R TP V + R + L + G ++ Sbjct: 266 RYESLVADPALVPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASAN 325 Query: 424 SSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKY 483 E+ F+ + + L ++ NP H+ FG G CIG +L L+L AL +++++ Sbjct: 326 RDEEVFDHADE------LDFHRERNP--HIAFGHGAHHCIGAQLGRLELQEALSALVRRF 377 >4UBS-A nrPDB Length = 393 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 45/197 (22%), Positives = 75/197 (38%), Gaps = 30/197 (15%) Query: 290 LQRYSQQPGADFLCDIYQQ----DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRN 345 + R ++PG L D+ Q+ + + EL + T L +A ETTAN + + L R+ Sbjct: 192 IDRKRKEPGDGLLDDLIQEQLNRGTVDRAELVSLATLLLIAGHETTANMISLGTFTLLRH 251 Query: 346 PQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLG 405 P+ L E P E+L + L V TT D+ V Sbjct: 252 PEQLAELRAE-----PGLMPAAVEELLRFLSIADGLLRVATEDIEVAGTTIRADEGVVFA 306 Query: 406 EYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGR 465 +N G +E + D H+ + H+ FG G C+G+ Sbjct: 307 TS--------VINRDAAGFAEPDALDWHR-------------SARHHVAFGFGIHQCLGQ 345 Query: 466 RLAELQLHLALCWIIQK 482 LA ++ +AL + ++ Sbjct: 346 NLARAEMEIALGTLFER 362 >6HQD-A nrPDB Length = 420 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 22/58 (37%), Positives = 31/58 (53%), Gaps = 4/58 (6%) Query: 452 HLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPV----EMLHLGILVPSR 505 HL FG G C+G RLAELQL + + ++Y + EPV ++H I +P R Sbjct: 360 HLSFGFGIHRCLGNRLAELQLKILWEEMCERYSRIEVCGEPVRVPSNLVHGYIDIPVR 417 >5HH3-A nrPDB Length = 397 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 47/200 (23%), Positives = 76/200 (38%), Gaps = 40/200 (20%) Query: 292 RYSQQPGADFLCDIYQQ--DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQ 349 R + PG D + ++ D ++ EL + A + A L + ++ +P+ Q Sbjct: 202 RTRRDPGDDMFGVVVREYGDEITDAELTGVAAFVMGAGADQVARFLAAGAWLMADDPE-Q 260 Query: 350 RRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMR-LTPSVPFTTRTLDKPTVLGEYA 408 LL+E +PD L E +R LT R +G++ Sbjct: 261 FALLREKPDTVPD-----------------WLDEVIRYLTTDEKTHPRVATDDVRIGDHL 303 Query: 409 LPKG-----TVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCI 463 + G ++L N + ED F D + RPE HL FG G C+ Sbjct: 304 IKAGDTVTCSLLAANRRNFPRPEDRF-DITRVRPE-------------HLAFGHGIHHCL 349 Query: 464 GRRLAELQLHLALCWIIQKY 483 GR LAEL A+ + ++ Sbjct: 350 GRSLAELVFRTAIPALAHRF 369 >6G5O-A nrPDB Length = 399 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 59/272 (21%), Positives = 110/272 (40%), Gaps = 47/272 (17%) Query: 263 LNTKVWQAHT-LAWDT-IFKSVKPC------------IDNRLQRYSQQPGAD----FLCD 304 LNT ++ T ++W T +F+S ID ++ R S+ PG D L Sbjct: 139 LNTPFSESETWISWGTHVFRSEGEALDGDKANILYHYIDEQIDRASENPGDDMYSVLLNS 198 Query: 305 IYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQ 364 ++ L+K+E+ + +T N++ + L+ +P+A RL +E + Sbjct: 199 EFEGRKLTKEEVKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRKEPEI------ 252 Query: 365 TPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGS 424 T RA ++E +R + R + + T + E+A+ + ++L Sbjct: 253 TGRA------------VEEMIRYFSPLTQMGRVVTEDTHVCEHAVKADSRISLCWASANR 300 Query: 425 SEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQK-- 482 FE+ ++ +R K+NP H+ FG C+G A L + L + QK Sbjct: 301 DAAVFENPNEIVLDR------KVNP--HVGFGFSHHNCLGATHARQILKILLQTLAQKVA 352 Query: 483 -YDIVATDNEPVEMLHLGILVPSRELPIAFRP 513 ++I+ ++ H V + I F P Sbjct: 353 SFEILDYKENIEDLDHFQRKVGFHNIQIKFNP 384 >3OFT-A nrPDB Length = 396 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 33/193 (17%) Query: 284 PCIDNRLQRYSQQPGADFLCDIYQQDHLSK----KELYAAVTELQLAAVETTANSLMWIL 339 P I+ R+ QPG D I + + E L ++T A + + Sbjct: 192 PFIEKRMA----QPGDDLFSRILSEPVGGRPWTVDEARRMCRNLLFGGLDTVAAMIGMVA 247 Query: 340 YNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLD 399 +L+R+P+ QR LL+E ++P A E MR P+V + + Sbjct: 248 LHLARHPEDQR-LLRERPDLIP-----------------AAADELMRRYPTVAVSRNAVA 289 Query: 400 KPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGK 459 G + KG ++ L + + +FE + R +R L P H G+G Sbjct: 290 DVDADG-VTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGLA------PIRHTTMGVGA 342 Query: 460 RMCIGRRLAELQL 472 C+G LA +++ Sbjct: 343 HRCVGAGLARMEV 355 >5H1Z-A nrPDB Length = 407 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 43/188 (22%), Positives = 73/188 (38%), Gaps = 28/188 (14%) Query: 292 RYSQQPGADFLCDIYQQDHLS---KKELYAAVTELQLAAVETTANSLMWILYNLSRNPQA 348 + + P D + + D ++ + E + L + +TT N++ + Y L P Sbjct: 208 KIGKPPTPDLISMMIHSDAMAEMDQMEFLGNLILLIVGGNDTTRNTMSAVAYGLDLFPD- 266 Query: 349 QRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYA 408 QR L+ S++P+ ++E +R + RT + L Sbjct: 267 QRAKLEADPSMIPN-----------------TVQEIIRWQTPLAHMRRTATVDSELEGQQ 309 Query: 409 LPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLA 468 + G L L E FE++ + +R N HL FG G C+G RLA Sbjct: 310 IKAGDKLALWYISANRDESVFENADRIIVDR-------PNARRHLAFGHGIHRCVGARLA 362 Query: 469 ELQLHLAL 476 ELQ+ + L Sbjct: 363 ELQIAVLL 370 >5HDI-A nrPDB Length = 404 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 29/114 (25%), Positives = 46/114 (40%), Gaps = 7/114 (6%) Query: 373 NMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDS 432 N L A ++E++R P R + T L LP + L L FE Sbjct: 273 NPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAP 332 Query: 433 HKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIV 486 +FR +R K H+ FG G C+G LA L+ + L ++ + ++ Sbjct: 333 GEFRLDRAGGK-------GHISFGKGAHFCVGAALARLEARIVLRLLLDRTSVI 379 >4YT3-A nrPDB Length = 410 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 42/192 (21%), Positives = 74/192 (38%), Gaps = 28/192 (14%) Query: 296 QPGADFLCDIYQQD----HLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRR 351 P D + D+ + + + E+ + A VETT++ L Y Sbjct: 209 NPADDIISDLLKSEVDGEMFTDDEVVRTTMLILGAGVETTSHLLANSFY----------- 257 Query: 352 LLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPK 411 S+L D++ E N+ + ++E +R ++ RT+ + L L + Sbjct: 258 ------SLLYDDKEVYQELHENLDLVPQAVEEMLRFRFNLIKLDRTVKEDNDLLGVELKE 311 Query: 412 GTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQ 471 G + + E+ FED R K+ HL FG G C+G LA L+ Sbjct: 312 GDSVVVWMSAANMDEEMFEDPFTLNIHRPNNKK-------HLTFGNGPHFCLGAPLARLE 364 Query: 472 LHLALCWIIQKY 483 +AL ++K+ Sbjct: 365 AKIALTAFLKKF 376 >4JBT-A nrPDB Length = 410 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 54/235 (22%), Positives = 96/235 (40%), Gaps = 45/235 (19%) Query: 269 QAHTLAWDTIFKSVKPCIDNRLQ--------------RYSQQPGADFLCD-IYQQDH--- 310 Q L W F S+ D RL+ R + +PG D IY D Sbjct: 169 QEQLLTWYKAFFSILTPQDERLRVIDEMHGYFTEMVRRKTAEPGDDLTSALIYATDGETP 228 Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED 370 L+++E+ + L A ETT + ++ + L +P+ Q RL+++ + +T E Sbjct: 229 LTEEEVIGNLQALVAAGHETTVSLILTAVRALLSHPE-QLRLVRDGEI---GWETAIEET 284 Query: 371 LR-NMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSS-EDN 428 LR + P + ++ F T +D LG+ +P+G + ++ + +G + Sbjct: 285 LRWDGPVIHLLMR----------FATEDID----LGDAVIPRGEGVVMSYRAIGRDITVH 330 Query: 429 FEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKY 483 D+ F R H+ FG G +C G LA L+ +AL + ++ Sbjct: 331 GADADDFDITRATAAR-------HISFGHGPHICPGAALARLEAAIALPALFTRF 378 >5XNT-A nrPDB Length = 411 Score = 38.1 bits (87), Expect = 0.010, Method: Compositional matrix adjust. Identities = 42/192 (21%), Positives = 75/192 (39%), Gaps = 28/192 (14%) Query: 296 QPGADFLCDIYQQD----HLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRR 351 P D + D+ + + + E+ + A VETT++ L Y Sbjct: 209 NPADDIISDLLKAEVDGEMFTDDEVVRTTMLILGAGVETTSHLLANSFY----------- 257 Query: 352 LLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPK 411 S+L D++ E N+ + ++E +R ++ RT+ + L L + Sbjct: 258 ------SLLYDDKEVYQELHENLDLVPQAVEEMLRYRFNLIKLDRTVKEDNDLLGVELKE 311 Query: 412 GTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQ 471 G + + E+ FED+ R K+ HL FG G C+G LA L+ Sbjct: 312 GENVVVWMSAANLDEEMFEDAFTLNIHRPNNKK-------HLTFGNGPHFCLGAPLARLE 364 Query: 472 LHLALCWIIQKY 483 +AL ++K+ Sbjct: 365 AKIALTTFLKKF 376 >5FOI-A nrPDB Length = 408 Score = 37.7 bits (86), Expect = 0.011, Method: Compositional matrix adjust. Identities = 42/183 (22%), Positives = 71/183 (38%), Gaps = 28/183 (15%) Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED 370 ++ +EL L A ET+AN + + L R+P+ A + Sbjct: 232 ITHQELVNNAVLLLAAGHETSANQVTLSVLTLLRHPET-------------------AAE 272 Query: 371 LRNMPYLKA-CLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNF 429 LR P L + E +R R VLG++ + G L +L SS ++ Sbjct: 273 LREQPELMPNAVDELLRYHSIADGLRRAATADIVLGDHTIRAGDGLI----ILLSSANH- 327 Query: 430 EDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATD 489 D + F E + H+ FG G C+G+ LA L++ + L + ++ + Sbjct: 328 -DGNTFGAEATFDIHRPAR--HHVAFGYGPHQCLGQNLARLEMEVTLGKLFRRVPALRLA 384 Query: 490 NEP 492 EP Sbjct: 385 QEP 387 >3EJB-B nrPDB Length = 404 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 42/192 (21%), Positives = 79/192 (41%), Gaps = 26/192 (13%) Query: 291 QRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQR 350 +R+ QQ L ++D L+++E + L +A ETT N + + L ++P+ Sbjct: 199 KRHPQQDMISMLLKGREKDKLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLL 258 Query: 351 RLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALP 410 +L + PD + ++E +R T R + + + Sbjct: 259 KLREN-----PD-------------LIGTAVEECLRYESPTQMTARVASEDIDICGVTIR 300 Query: 411 KGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAEL 470 +G + L +LG++ D F + NP HL FG G +C+G LA L Sbjct: 301 QGEQVYL---LLGAAN---RDPSIFTNPDVFDITRSPNP--HLSFGHGHHVCLGSSLARL 352 Query: 471 QLHLALCWIIQK 482 + +A+ ++Q+ Sbjct: 353 EAQIAINTLLQR 364 >3IVY-A nrPDB Length = 433 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 44/186 (23%), Positives = 69/186 (37%), Gaps = 33/186 (17%) Query: 294 SQQPGADFLCDIYQQD----HLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQ 349 ++ P D + + Q D LS E V L +A ETT NS+ + + +P Q Sbjct: 232 AKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFAEHPD-Q 290 Query: 350 RRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYAL 409 L ++V+ + E +R V RT + L + Sbjct: 291 WELYKKVRP-------------------ETAADEIVRWATPVTAFQRTALRDYELSGVQI 331 Query: 410 PKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFG-IGKRMCIGRRLA 468 KG + + + E+ F+D F R NP H+ FG G CIG LA Sbjct: 332 KKGQRVVMFYRSANFDEEVFQDPFTFNILR--------NPNPHVGFGGTGAHYCIGANLA 383 Query: 469 ELQLHL 474 + ++L Sbjct: 384 RMTINL 389 >3A1L-A nrPDB Length = 425 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 32/169 (18%) Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED 370 LS + L A ETT N L + L +A R +L E+++ TP Sbjct: 239 LSVDGIVGTCVHLLTAGHETTTNFLAKAVLTL----RAHRDVLDELRTT--PESTP---- 288 Query: 371 LRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDN-- 428 A ++E MR P V TR + LG++ +P+G+ + +LGS+ + Sbjct: 289 --------AAVEELMRYDPPVQAVTRWAYEDIRLGDHDIPRGSRV---VALLGSANRDPA 337 Query: 429 -FEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLAL 476 F D R +++ + FG+G C+G LA + + L Sbjct: 338 RFPDPDVLDVHRAAERQ--------VGFGLGIHYCLGATLARAEAEIGL 378 >5OMS-A nrPDB Length = 409 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 42/197 (21%), Positives = 68/197 (34%), Gaps = 28/197 (14%) Query: 282 VKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKE-LYAAVTELQLAAVETTANSLMWILY 340 V P ID ++ + +L D +E +Y + L A++ + + L Sbjct: 202 VDPLIDKWIEHPDDSAISHWLHDGMPPGQTRDREYIYPTIYVYLLGAMQEPGHGMASTLV 261 Query: 341 NLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLT-PSVPFTTRTLD 399 L P+ ++ + + PRA + E +R T P T R Sbjct: 262 GLFSRPEQLEEVVDDPTLI------PRA------------IAEGLRWTSPIWSATARIST 303 Query: 400 KPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGK 459 KP + LP GT + L+ +E ++ R P HL FG G Sbjct: 304 KPVTIAGVDLPAGTPVMLSYGSANHDTGKYEAPSQYDLHR--------PPLPHLAFGAGN 355 Query: 460 RMCIGRRLAELQLHLAL 476 C G A + +AL Sbjct: 356 HACAGIYFANHVMRIAL 372 >6FSH-A nrPDB Length = 398 Score = 37.4 bits (85), Expect = 0.016, Method: Compositional matrix adjust. Identities = 41/199 (20%), Positives = 82/199 (41%), Gaps = 33/199 (16%) Query: 290 LQRYSQQPGADFLCDIYQQ--DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQ 347 + R + PG F+ I + D ++ +EL +L LA + + + + L R+P+ Sbjct: 198 IARERKDPGDGFIGSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPE 257 Query: 348 AQRRLLQEVQSVLPDNQTP-RAEDLRNMPYLKACLKESMRLTPSVPF--TTRTLDKPTVL 404 ++ ++ D+Q+ RA D E +R +VP+ T RT + ++ Sbjct: 258 -------QIAALRGDDQSADRAVD------------ELIRYL-TVPYAPTPRTAVEDVMV 297 Query: 405 GEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIG 464 + + +G + + + D+ + R P H+ FG G C+G Sbjct: 298 ADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR--------TPVPHVAFGHGIHHCLG 349 Query: 465 RRLAELQLHLALCWIIQKY 483 L LQL +A + +++ Sbjct: 350 AALTRLQLRIAYTALWRRF 368 >1ODO-A nrPDB Length = 408 Score = 37.4 bits (85), Expect = 0.016, Method: Compositional matrix adjust. Identities = 48/212 (22%), Positives = 81/212 (38%), Gaps = 43/212 (20%) Query: 285 CIDNRLQRYSQQPGADFLC-------DIYQQDHLSKKELYAAVTELQLAAVETTANSLMW 337 +D + PG D D D LS +EL + + A ETT N + Sbjct: 194 VLDQLIAAKRATPGDDMTSLLIAARDDEGDGDRLSPEELRDTLLLMISAGYETTVNVIDQ 253 Query: 338 ILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRT 397 ++ L P Q L+++ + D ++E++R P+V + Sbjct: 254 AVHTLLTRPD-QLALVRKGEVTWAD-----------------VVEETLRHEPAV----KH 291 Query: 398 LDKPTVLGEYALPKGTVLTLNTQVLGS------SEDNFEDSHKFRPERWLQKEKKINPFA 451 L + + ALP G + +L S D ED+ F R +++ Sbjct: 292 LPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADTFDATRTVKE-------- 343 Query: 452 HLPFGIGKRMCIGRRLAELQLHLALCWIIQKY 483 HL FG G C+G LA +++ LAL + ++ Sbjct: 344 HLAFGHGVHFCLGAPLARMEVTLALESLFGRF 375 >4TX3-A nrPDB Length = 404 Score = 37.4 bits (85), Expect = 0.018, Method: Compositional matrix adjust. Identities = 41/199 (20%), Positives = 82/199 (41%), Gaps = 33/199 (16%) Query: 290 LQRYSQQPGADFLCDIYQQ--DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQ 347 + R + PG F+ I + D ++ +EL +L LA + + + + L R+P+ Sbjct: 204 MARERKDPGDGFIGSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPE 263 Query: 348 AQRRLLQEVQSVLPDNQTP-RAEDLRNMPYLKACLKESMRLTPSVPF--TTRTLDKPTVL 404 ++ ++ D+Q+ RA D E +R +VP+ T RT + ++ Sbjct: 264 -------QIAALRGDDQSADRAVD------------ELIRYL-TVPYAPTPRTAVEDVMV 303 Query: 405 GEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIG 464 + + +G + + + D+ + R P H+ FG G C+G Sbjct: 304 ADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR--------TPVPHVAFGHGIHHCLG 355 Query: 465 RRLAELQLHLALCWIIQKY 483 L LQL +A + +++ Sbjct: 356 AALTRLQLRIAYTALWRRF 374 >6G71-A nrPDB Length = 405 Score = 37.0 bits (84), Expect = 0.021, Method: Compositional matrix adjust. Identities = 28/102 (27%), Positives = 39/102 (38%), Gaps = 8/102 (7%) Query: 371 LRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFE 430 LR+ A +ES+R + R T L Y +P+G L L + Sbjct: 263 LRDPKLWGAVFEESIRWVAPIGMVPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWS 322 Query: 431 DSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQL 472 D +F ER AHL FG G +C+G A Q+ Sbjct: 323 DPDRFDIER--------GSEAHLAFGKGVHVCLGAWAARSQV 356 >6CVC-A nrPDB Length = 433 Score = 36.6 bits (83), Expect = 0.024, Method: Compositional matrix adjust. Identities = 49/203 (24%), Positives = 79/203 (38%), Gaps = 29/203 (14%) Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED 370 LS E+ L +A ETT N++ + LSR P + + + + Sbjct: 256 LSSSEIAMFFILLVVAGNETTRNAISHGMLALSRYPDERAKWWSDFDGL----------- 304 Query: 371 LRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFE 430 ++E +R V + RTL + L + G +TL E+ F Sbjct: 305 ------AATAVEEIVRWASPVVYMRRTLSQDVDLRGTKMAAGDKVTLWYCSANRDEEKFA 358 Query: 431 DSHKFRPERWLQKEKKINPFAHLPF-GIGKRMCIGRRLAELQLHLALCWIIQKY-DIVAT 488 D F R NP + F G G C+G LA ++ + + ++ D+VAT Sbjct: 359 DPWTFDVTR--------NPNPQVGFGGGGAHFCLGANLARREIRVVFDELRRQMPDVVAT 410 Query: 489 DNEPVEMLHLGILVPSRELPIAF 511 + EP +L I R LP+A+ Sbjct: 411 E-EPARLLSQFIHGIKR-LPVAW 431 >5IT1-A nrPDB Length = 399 Score = 36.2 bits (82), Expect = 0.039, Method: Compositional matrix adjust. Identities = 16/56 (28%), Positives = 30/56 (53%), Gaps = 3/56 (5%) Query: 428 NFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKY 483 +F+ + PER+ + P HL FG G CIG++LA ++L + + +++ Sbjct: 317 DFDPAFVEDPERF---DITRRPAPHLAFGFGAHQCIGQQLARIELQIVFGTLFRRF 369 >2RFC-A nrPDB Length = 343 Score = 35.8 bits (81), Expect = 0.040, Method: Compositional matrix adjust. Identities = 17/45 (37%), Positives = 25/45 (55%) Query: 452 HLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEML 496 HL FGIG MC+G LA L+ +AL I+ + + D + +L Sbjct: 285 HLAFGIGIHMCLGAPLARLEASIALNDILNHFKRIKIDYKKSRLL 329 >2Z36-A nrPDB Length = 413 Score = 35.4 bits (80), Expect = 0.059, Method: Compositional matrix adjust. Identities = 46/211 (21%), Positives = 82/211 (38%), Gaps = 35/211 (16%) Query: 279 FKSVKPCIDNRLQRYSQQPGADF----LCDIYQQDHLSKKELYAAVTELQLAAVETTANS 334 F ++ ID+ + R +PG D + Q+ L L + L A ETTAN Sbjct: 194 FAELRAYIDDLITRKESEPGDDLFSRQIARQRQEGTLDHAGLVSLAFLLLTAGHETTANM 253 Query: 335 LMWILYNLSRNPQAQRRLLQEVQSVLPDN--QTPRAEDLRNMPYLKACLKESMR-LTPSV 391 + + L +P E +V+ N +TP A ++E +R T + Sbjct: 254 ISLGVVGLLSHP--------EQLTVVKANPGRTPMA------------VEELLRYFTIAD 293 Query: 392 PFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFA 451 T+R + +G ++ G + ++ F+D ER + Sbjct: 294 GVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVERGARH-------- 345 Query: 452 HLPFGIGKRMCIGRRLAELQLHLALCWIIQK 482 HL FG G C+G+ LA ++L + + ++ Sbjct: 346 HLAFGFGPHQCLGQNLARMELQIVFDTLFRR 376 >3BUJ-A nrPDB Length = 397 Score = 35.4 bits (80), Expect = 0.066, Method: Compositional matrix adjust. Identities = 41/171 (23%), Positives = 65/171 (38%), Gaps = 26/171 (15%) Query: 301 FLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVL 360 + D + + +S+ E+ + V ET A+ + + +L +P Q LL+ Sbjct: 208 LMLDAHDRGLMSRNEIVSTVVTFIFTGHETVASQVGNAVLSLLAHPD-QLDLLR------ 260 Query: 361 PDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQ 420 R DL L ++E +R PSV TR LD L L + V+ + Sbjct: 261 ------RRPDL-----LAQAVEECLRYDPSVQSNTRQLDVDVELRGRRLRRDDVVVVLAG 309 Query: 421 VLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQ 471 ++ F ER +P + FG G R C+G LA Q Sbjct: 310 AANRDPRRYDRPDDFDIER--------DPVPSMSFGAGMRYCLGSYLARTQ 352 >5XW2-A nrPDB Length = 419 Score = 35.0 bits (79), Expect = 0.069, Method: Compositional matrix adjust. Identities = 29/115 (25%), Positives = 48/115 (41%), Gaps = 8/115 (6%) Query: 377 LKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFR 436 + L+ESMR V T R + + G L+ + V+ D+ +F Sbjct: 289 IPGLLEESMRFLSPVAATYRATTRDVEVA------GQRLSADQMVMVWFGAANRDARQFA 342 Query: 437 PERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNE 491 + NP HL FG G C+G LA ++ +AL ++ ++ + TD E Sbjct: 343 EPELFDMTRGPNP--HLGFGRGIHFCLGGPLARMEGRVALDHLLDRFPELYTDPE 395 >5HIW-A nrPDB Length = 398 Score = 35.0 bits (79), Expect = 0.072, Method: Compositional matrix adjust. Identities = 40/172 (23%), Positives = 68/172 (39%), Gaps = 26/172 (15%) Query: 318 AAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYL 377 V L L + ETT+ L +L L +P A +L Q+ S+LP Sbjct: 220 GVVLTLILGSYETTSWMLANLLVALLAHPDAMNQLRQQ-PSLLPQ--------------- 263 Query: 378 KACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRP 437 ++ES R S R +++ +G L GT+L L+ E+ + F Sbjct: 264 --AIEESTRWCSSAAGIVRFVEREATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDI 321 Query: 438 ERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATD 489 R P L FG G C+G LA ++ + + +++++ + D Sbjct: 322 HR--------RPVGMLNFGGGLHYCVGAPLARMEARVGVSLLLERFPALRAD 365 >4FB2-A nrPDB Length = 398 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 43/221 (19%), Positives = 79/221 (35%), Gaps = 40/221 (18%) Query: 296 QPGADFLCDIYQQ----DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRR 351 PG D + + + LS+ +L T L L ++ TA L + + L+ + + +RR Sbjct: 198 NPGNDIMSRVIMSKIDGESLSEDDLIGFFTILLLGGIDNTARFLSSVFWRLAWDIELRRR 257 Query: 352 LLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPK 411 L+ + + P A D E +R R + + +G+ + Sbjct: 258 LIAHPELI------PNAVD------------ELLRFYGPA-MVGRLVTQEVTVGDITMKP 298 Query: 412 GTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQ 471 G L + F+ ER P HL G G C+G L ++ Sbjct: 299 GQTAMLWFPIASRDRSAFDSPDNIVIER--------TPNRHLSLGHGIHRCLGAHLIRVE 350 Query: 472 LHLALCWIIQKYDIVATD---------NEPVEMLHLGILVP 503 +A+ +++ + D + MLH+ I+ P Sbjct: 351 ARVAITEFLKRIPEFSLDPNKECEWLMGQVAGMLHVPIIFP 391 >6FYJ-A nrPDB Length = 421 Score = 34.3 bits (77), Expect = 0.14, Method: Compositional matrix adjust. Identities = 25/120 (20%), Positives = 50/120 (41%), Gaps = 6/120 (5%) Query: 376 YLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKF 435 Y + ++E R P PF + K Y +GT+ L+ + +++ F Sbjct: 279 YSQMFVQEVRRFYPFFPFVVALVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVF 338 Query: 436 RPERWLQKEKKINPFAHLPFGIGKRM----CIGRRLAELQLHLALCWIIQKYDIVATDNE 491 P+R+ + E +PF+ +P G G C G + + ++L ++ + D D + Sbjct: 339 SPDRFAKWEG--SPFSFIPQGGGDYFMGHRCAGEWVTIEVMKVSLDYLTNRMDYEVPDQD 396 >5M0P-A nrPDB Length = 428 Score = 33.9 bits (76), Expect = 0.17, Method: Compositional matrix adjust. Identities = 34/137 (24%), Positives = 56/137 (40%), Gaps = 10/137 (7%) Query: 363 NQTPRA-EDLRNMP-YLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQ 420 N+ P E +++ P Y +E R P VPF +P G L L+ Sbjct: 268 NENPITREKIKSEPDYAYKFAQEVRRYYPFVPFLPGKAKVDIDFQGVTIPAGVGLALDVY 327 Query: 421 VLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIG----KRMCIGRRLAELQLHLAL 476 E ++D ++FRPER+ + +PF +P G G C G + + + + Sbjct: 328 GTTHDESLWDDPNEFRPERFETWDG--SPFDLIPQGGGDYWTNHRCAGEWITVIIMEETM 385 Query: 477 CWIIQK--YDIVATDNE 491 + +K YD+ D E Sbjct: 386 KYFAEKITYDVPEQDLE 402 >3ABA-A nrPDB Length = 403 Score = 33.9 bits (76), Expect = 0.18, Method: Compositional matrix adjust. Identities = 16/55 (29%), Positives = 29/55 (52%), Gaps = 3/55 (5%) Query: 428 NFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQK 482 +F+ + PER+ + P HL FG G CIG++LA ++L + + ++ Sbjct: 317 DFDPAFVEEPERF---DITRRPAPHLAFGFGAHQCIGQQLARIELQIVFETLFRR 368 >3OO3-A nrPDB Length = 384 Score = 33.5 bits (75), Expect = 0.24, Method: Compositional matrix adjust. Identities = 14/32 (43%), Positives = 20/32 (62%) Query: 452 HLPFGIGKRMCIGRRLAELQLHLALCWIIQKY 483 H+ FG G CIG LA LQL +AL ++ ++ Sbjct: 322 HMAFGHGIHHCIGAPLARLQLRVALPAVVGRF 353 >6GK6-A nrPDB Length = 411 Score = 33.5 bits (75), Expect = 0.25, Method: Compositional matrix adjust. Identities = 38/178 (21%), Positives = 71/178 (39%), Gaps = 29/178 (16%) Query: 307 QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTP 366 Q+ LS EL + V L +A ETT + + + L +P +RRL ++ V Sbjct: 224 QEHKLSPAELSSMVFLLLVAGHETTVHLIASGMLLLLSHPAERRRLDEDPGLV------- 276 Query: 367 RAEDLRNMPYLKACLKESMRLTPSVPFTTR--TLDKPTVLGEYALPKGTVLTLNTQVLGS 424 + ++E++R +T +L+ + G +P G + Sbjct: 277 -----------GSAVEEALRCEGPAELSTIRWSLEDIELFGAR-VPAGEGVAAGLLAANR 324 Query: 425 SEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQK 482 +F D +F R +P H+ FG G C+G LA ++ +A ++++ Sbjct: 325 DPQHFPDPDRFDIGR--------SPNRHIGFGGGIHFCLGAMLARIEAAIAFSTLLRR 374 >2RCM-A nrPDB Length = 495 Score = 33.1 bits (74), Expect = 0.29, Method: Compositional matrix adjust. Identities = 33/152 (21%), Positives = 59/152 (38%), Gaps = 15/152 (9%) Query: 347 QAQRRLLQEVQSVLPDNQTP-RAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVL- 404 Q RL +E++SV+ N + M K+ + E +R P V K V+ Sbjct: 316 QVHNRLAEEIRSVIKSNGGELTMGAIEKMELTKSVVYECLRFEPPVTAQYGRAKKDLVIE 375 Query: 405 ---GEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKI---------NPFAH 452 + + G +L + F+ + +F PER++ +E + P Sbjct: 376 SHDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEEGEKLLRHVLWSNGPETE 435 Query: 453 LPFGIGKRMCIGRRLAELQLHLALCWIIQKYD 484 P +G + C G+ L L + I ++YD Sbjct: 436 TP-TVGNKQCAGKDFVVLVARLFVIEIFRRYD 466 >2ZBZ-A nrPDB Length = 412 Score = 32.7 bits (73), Expect = 0.34, Method: Compositional matrix adjust. Identities = 45/201 (22%), Positives = 81/201 (40%), Gaps = 29/201 (14%) Query: 286 IDNRLQRYSQQPGADFL----CDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYN 341 +D + ++ +PGA + D + ++EL + L +A ETTA+ + Sbjct: 200 LDGLITQFQTEPGAGLVGALVADQLANGEIDREELISTAMLLLIAGHETTASMTSLSVIT 259 Query: 342 LSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKP 401 L +P+ Q L+ +S++P E+L + YL R+ T D Sbjct: 260 LLDHPE-QYAALRADRSLVPGA----VEEL--LRYLAIADIAGGRVA--------TADI- 303 Query: 402 TVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRM 461 V G+ V+ +N+ + +ED R + HL FG G Sbjct: 304 EVEGQLIRAGEGVIVVNS-IANRDGTVYEDPDALDIHRSARH--------HLAFGFGVHQ 354 Query: 462 CIGRRLAELQLHLALCWIIQK 482 C+G+ LA L+L + L ++ + Sbjct: 355 CLGQNLARLELEVILNALMDR 375 >5OCD-A nrPDB Length = 266 Score = 32.7 bits (73), Expect = 0.36, Method: Compositional matrix adjust. Identities = 16/38 (42%), Positives = 20/38 (52%) Query: 143 EAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKIN 180 E Y L + EG EW + F K+L P EIM+ D N Sbjct: 83 ELYQLAVKEGDEWLKRNQRFYKQLTIPFEIMRWDDWYN 120 >2UUQ-A nrPDB Length = 414 Score = 32.7 bits (73), Expect = 0.39, Method: Compositional matrix adjust. Identities = 35/141 (24%), Positives = 58/141 (41%), Gaps = 25/141 (17%) Query: 342 LSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKP 401 L R P QRRLL + +PD ++E +RLT V RT + Sbjct: 266 LHRRPD-QRRLLLDDPEGIPD-----------------AVEELLRLTSPVQGLARTTTRD 307 Query: 402 TVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRM 461 +G+ +P G + L + GS+ D ++ P+ + + P L F G Sbjct: 308 VTIGDTTIPAGRRVLL---LYGSAN---RDERQYGPDA-AELDVTRCPRNILTFSHGAHH 360 Query: 462 CIGRRLAELQLHLALCWIIQK 482 C+G A +Q +AL ++ + Sbjct: 361 CLGAAAARMQCRVALTELLAR 381 >3TYW-A nrPDB Length = 417 Score = 32.7 bits (73), Expect = 0.43, Method: Compositional matrix adjust. Identities = 12/31 (38%), Positives = 21/31 (67%) Query: 452 HLPFGIGKRMCIGRRLAELQLHLALCWIIQK 482 H+ FG G C+G+ LA L+L +AL ++++ Sbjct: 350 HVAFGYGVHQCVGQHLARLELEVALETLLRR 380 >6B11-A nrPDB Length = 440 Score = 32.7 bits (73), Expect = 0.43, Method: Compositional matrix adjust. Identities = 11/31 (35%), Positives = 21/31 (67%) Query: 452 HLPFGIGKRMCIGRRLAELQLHLALCWIIQK 482 H+ FG G C+G+ LA ++L +AL ++++ Sbjct: 379 HVAFGYGPHQCLGQNLARMELEVALGAVLER 409 >1Q5D-A nrPDB Length = 419 Score = 32.3 bits (72), Expect = 0.45, Method: Compositional matrix adjust. Identities = 45/199 (22%), Positives = 77/199 (38%), Gaps = 47/199 (23%) Query: 310 HLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQE-------VQSVLPD 362 LS KEL A V + A +TT + + + NL R+P+A + E + VL Sbjct: 238 RLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAEPGLMRNALDEVLRF 297 Query: 363 NQTPRAEDLR----NMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLN 418 + R +R ++ Y A +K+ + +P AL GTV + Sbjct: 298 DNILRIGTVRFARQDLEYCGASIKKGEMVFLLIP--------------SALRDGTVFS-- 341 Query: 419 TQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCW 478 RP+ + + + + A L +G G +C G LA L+ +A+ Sbjct: 342 -----------------RPDVF---DVRRDTSASLAYGRGPHVCPGVSLARLEAEIAVGT 381 Query: 479 IIQKYDIVATDNEPVEMLH 497 I +++ + PV H Sbjct: 382 IFRRFPEMKLKETPVFGYH 400 >5EX6-C nrPDB Length = 434 Score = 32.3 bits (72), Expect = 0.47, Method: Compositional matrix adjust. Identities = 38/198 (19%), Positives = 78/198 (39%), Gaps = 31/198 (15%) Query: 290 LQRYSQQPGADFLCDIYQQ--DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQ 347 + R + PG + + + D ++ +EL ++ LA + + + + L RNP+ Sbjct: 234 VARERKDPGDGLIGMVVAEHGDTVTDEELRGVCVQMMLAGDDNISGMIGLGVLALLRNPE 293 Query: 348 AQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF--TTRTLDKPTVLG 405 L +V P + + E +R +VP+ T RT + + +G Sbjct: 294 QIAALRGDV------------------PAAERAVDELIRYL-TVPYAPTPRTAIEDSTVG 334 Query: 406 EYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGR 465 + + G + + D+ + L ++ P H+ FG G C+G Sbjct: 335 DQVIKAGETVLCSLPTANRDPALLPDADR------LDVTREAVP--HVAFGHGVHHCLGA 386 Query: 466 RLAELQLHLALCWIIQKY 483 LA L+L +A + +++ Sbjct: 387 ALARLELRIAYTALWRRF 404 >6GII-A nrPDB Length = 479 Score = 32.3 bits (72), Expect = 0.55, Method: Compositional matrix adjust. Identities = 22/100 (22%), Positives = 37/100 (37%), Gaps = 7/100 (7%) Query: 377 LKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFR 436 + A +E +R V R + + LP G + + +F+D F Sbjct: 341 IPAAAEECLRYNGPVAGWRRRTTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFFD 400 Query: 437 PERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLAL 476 R N HL FG G C+GR L +++ + + Sbjct: 401 IGR-------SNASEHLNFGYGAHQCLGRNLGRMEMQIMI 433 >5EX8-A nrPDB Length = 424 Score = 32.0 bits (71), Expect = 0.62, Method: Compositional matrix adjust. Identities = 42/181 (23%), Positives = 69/181 (38%), Gaps = 38/181 (20%) Query: 309 DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRA 368 D ++ EL + AA + A L + + P AQ LL+E +P+ Sbjct: 248 DAITDAELTGVAAFVMGAAADQVARLLAAGAWLMVEQP-AQFALLREKPETVPE------ 300 Query: 369 EDLRNMPYLKACLKESMR-LTPSVPFTTRTLDKPTVLGEYALPKG-----TVLTLNTQVL 422 L E+MR LT R + +G + G ++L N Sbjct: 301 -----------WLDETMRYLTTDEKTHPRVATQDVRIGNQLVKAGDTVTCSLLAANRPNY 349 Query: 423 GSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQK 482 S+ED F+ + +EK HL FG G C+GR +AEL +++ + + Sbjct: 350 PSAEDEFD----------ITREKA----EHLAFGHGIHHCLGRAMAELMFKVSIPALAHR 395 Query: 483 Y 483 + Sbjct: 396 F 396 >2ZQJ-A nrPDB Length = 417 Score = 31.6 bits (70), Expect = 0.84, Method: Compositional matrix adjust. Identities = 24/80 (30%), Positives = 40/80 (50%), Gaps = 6/80 (7%) Query: 381 LKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDN--FEDSHKFRPE 438 ++E R P PF + K V KGT + L+ + G++ D ++ +FRPE Sbjct: 280 VQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLD--LYGTNHDPRLWDHPDEFRPE 337 Query: 439 RWLQKEKKINPFAHLPFGIG 458 R+ ++E+ N F +P G G Sbjct: 338 RFAEREE--NLFDMIPQGGG 355 >1EHE-A nrPDB Length = 403 Score = 31.6 bits (70), Expect = 0.84, Method: Compositional matrix adjust. Identities = 22/88 (25%), Positives = 36/88 (40%), Gaps = 6/88 (6%) Query: 396 RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPF 455 RT + ++G+ + + + Q E+ FE+ +F R K P L F Sbjct: 292 RTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNR------KWPPQDPLGF 345 Query: 456 GIGKRMCIGRRLAELQLHLALCWIIQKY 483 G G CI LA+ +L + QK+ Sbjct: 346 GFGDHRCIAEHLAKAELTTVFSTLYQKF 373 >5YHJ-A nrPDB Length = 413 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 24/96 (25%), Positives = 41/96 (42%), Gaps = 3/96 (3%) Query: 381 LKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERW 440 ++E R P P + YA P+GT+ L+ + + +F P R+ Sbjct: 276 VQEVRRFYPFFPVAAARVKTDFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSRF 335 Query: 441 LQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLAL 476 K+ K +PF +P G G + G R A + +A+ Sbjct: 336 --KDWKESPFNFIPQG-GGDVDFGHRCAGEHVTIAI 368 >5VWS-A nrPDB Length = 393 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 28/110 (25%), Positives = 50/110 (45%), Gaps = 14/110 (12%) Query: 377 LKACLKESMRL-TPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDN--FEDSH 433 + A L+ES+RL +P + T T+ GE +P + +L ++ D+ F D Sbjct: 266 IPAALEESLRLRSPFLQAGRVTTRDVTIAGE-TIPANRFVM--AWILSANHDDRRFPDPE 322 Query: 434 KFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKY 483 +F R H+ FG G C+G +L L+ +AL ++ ++ Sbjct: 323 RFDLHR--------QTTGHIAFGHGVHFCLGAQLGRLEGRIALERLLGRF 364 >4G0L-A nrPDB Length = 328 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 21/102 (20%), Positives = 43/102 (42%), Gaps = 3/102 (2%) Query: 206 ELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNT 265 ELN W ++++ +Y+ F Q+ +E ++ + G+ + Sbjct: 181 ELNGWIYDTVNNGVYKAGFATSQEAYDEAVAKVFESLARLEQILGQHRYLTGNQLTEADI 240 Query: 266 KVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQ 307 ++W + +D ++ + C +R+ Y G FL DIYQ Sbjct: 241 RLWTT-LVRFDPVYVTHFKCDKHRISDYLNLYG--FLRDIYQ 279 >6F0B-A nrPDB Length = 395 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 11/31 (35%), Positives = 20/31 (64%) Query: 452 HLPFGIGKRMCIGRRLAELQLHLALCWIIQK 482 H+ FG G C+G+ LA ++L A+ +I++ Sbjct: 334 HVGFGYGPHQCVGQALARVELQEAIPAVIRR 364 >3DBM-A nrPDB Length = 473 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 35/169 (20%), Positives = 66/169 (39%), Gaps = 24/169 (14%) Query: 333 NSLMWI-LYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSV 391 N+L WI L + + Q + ++S N T E + MP K+ + ES+R+ P V Sbjct: 287 NTLKWIGLAGENLHTQLAEEIRGAIKSYGDGNVT--LEAIEQMPLTKSVVYESLRIEPPV 344 Query: 392 P---------FTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQ 442 P FT + D + + KG +L F+ ++ P+R++ Sbjct: 345 PPQYGKAKSNFTIESHD-----ATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRFVG 399 Query: 443 KEKKINPFAHLPFG-------IGKRMCIGRRLAELQLHLALCWIIQKYD 484 + + + G + + C G+ L L + + ++YD Sbjct: 400 DGEALLKYVWWSNGPETESPTVENKQCAGKDFVVLITRLFVIELFRRYD 448 >6J9S-A nrPDB Length = 326 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 14/41 (34%), Positives = 24/41 (58%) Query: 124 AHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQK 164 AHP+ E K K + D RN+AY ++ L+G + + +A + Sbjct: 205 AHPEIKEDKLVKMFEDVRNKAYEIIKLKGATFYGIATALAR 245 >1VBH-A nrPDB Length = 876 Score = 29.6 bits (65), Expect = 3.3, Method: Compositional matrix adjust. Identities = 24/91 (26%), Positives = 43/91 (47%), Gaps = 14/91 (15%) Query: 372 RNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFED 431 R +PY ++ + R +P T R LD P L E+ LP+G + + +++ + N ED Sbjct: 597 RLLPYQRSDFEGIFRAMDGLPVTIRLLDPP--LHEF-LPEGNIEDIVSELCAETGANQED 653 Query: 432 SHKFRPERWLQKEKKINPFAHLPFGIGKRMC 462 + ++K ++NP +G R C Sbjct: 654 ALA-----RIEKLSEVNPM------LGFRGC 673 >4I6M-A nrPDB Length = 477 Score = 29.3 bits (64), Expect = 3.8, Method: Compositional matrix adjust. Identities = 20/66 (30%), Positives = 37/66 (56%), Gaps = 5/66 (7%) Query: 175 LDKKINEVLADFLER---MDELCDERGRIPDLYSELNKW--SFESICLVLYEKRFGLLQK 229 LD +++E LA ++ M+ + DE+ R D++ E + W F+S L + EK L++ Sbjct: 189 LDFQVHERLAPLIKEENDMENMADEQKRSTDVWYEASTWIQQFKSTMLQVSEKDLFELER 248 Query: 230 ETEEEA 235 +E+A Sbjct: 249 YYKEQA 254 >6GMF-A nrPDB Length = 397 Score = 28.9 bits (63), Expect = 4.9, Method: Compositional matrix adjust. Identities = 38/168 (22%), Positives = 65/168 (38%), Gaps = 26/168 (15%) Query: 309 DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRA 368 + L+ E+ + L +A ETT + + L L+ +P+ L Q+ Sbjct: 216 EKLTAGEVLSFANTLLIAGNETTTSLIGNALVALTDHPEQ----LAAAQA---------- 261 Query: 369 EDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDN 428 DL +P A ++E +R R +G+ +P +V+ E Sbjct: 262 -DLSLVP---AVVEEVLRYESPAQCIFRQTMTDVEIGDERIPARSVVLPLLASANRDESR 317 Query: 429 FEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLAL 476 F D +F + ++ K HL FG+ CIG LA L+ + L Sbjct: 318 FPDPDRFD----IHRDTK----GHLAFGLDIHFCIGAPLARLEAKVML 357 >5Y1I-A nrPDB Length = 403 Score = 28.9 bits (63), Expect = 6.0, Method: Compositional matrix adjust. Identities = 41/194 (21%), Positives = 74/194 (38%), Gaps = 26/194 (13%) Query: 298 GADFLCDIYQQ---DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQ 354 G D L D+ Q +++ + L A ETTAN + L NP+ L Sbjct: 206 GDDILSDLAVQVEAGEITQDDAAGIGMMLLGAGHETTANMIALGTLALLENPEQ----LA 261 Query: 355 EVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTV-LGEYALPKGT 413 EV+ D+ P+ + ++E +R T R + + +G + G Sbjct: 262 EVR----DSDDPKV--------IVNTVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGE 309 Query: 414 VLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLH 473 + D + ++ P+R + N HL FG G C+G LA ++L Sbjct: 310 GIVFPLNAANWDPDLYPEA----PDRL--DIHRANARRHLAFGYGVHQCLGATLARVELQ 363 Query: 474 LALCWIIQKYDIVA 487 + ++++ +A Sbjct: 364 IVYSTLLRRIPTLA 377 >6M7L-A nrPDB Length = 404 Score = 28.9 bits (63), Expect = 6.1, Method: Compositional matrix adjust. Identities = 10/32 (31%), Positives = 19/32 (59%) Query: 452 HLPFGIGKRMCIGRRLAELQLHLALCWIIQKY 483 H+ FG G C+G LA ++L +A ++ ++ Sbjct: 342 HVAFGHGIHHCLGAPLARMELRIAFTTLVSRF 373 >2IJ7-A nrPDB Length = 396 Score = 28.5 bits (62), Expect = 7.0, Method: Compositional matrix adjust. Identities = 39/174 (22%), Positives = 71/174 (40%), Gaps = 26/174 (14%) Query: 310 HLSKKELYAAV-TELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRA 368 H+S EL+A + A V +T + L L +L + PQ R LL E ++P Sbjct: 217 HVSD-ELFATIGVTFFGAGVISTGSFLTTALISLIQRPQL-RNLLHEKPELIPAG----- 269 Query: 369 EDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDN 428 ++ L+ ++ +P R +G+ + KG ++ + + N Sbjct: 270 --------VEELLRINLSFADGLP---RLATADIQVGDVLVRKGELVLVLLE-----GAN 313 Query: 429 FEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQK 482 F+ H P + + NP +HL FG G+ C G L + + +++K Sbjct: 314 FDPEHFPNPGSI--ELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKK 365 >5YSW-A nrPDB Length = 441 Score = 28.1 bits (61), Expect = 8.7, Method: Compositional matrix adjust. Identities = 19/66 (28%), Positives = 31/66 (46%), Gaps = 10/66 (15%) Query: 452 HLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVE------MLHLGILVPSR 505 HL FG G C+G++LA +++ ++++ V P E ML G+ Sbjct: 377 HLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVPPEEVPLRNDMLTYGV----H 432 Query: 506 ELPIAF 511 LPIA+ Sbjct: 433 SLPIAW 438 >3EB7-A nrPDB Length = 589 Score = 28.1 bits (61), Expect = 9.3, Method: Compositional matrix adjust. Identities = 16/67 (23%), Positives = 34/67 (50%), Gaps = 2/67 (2%) Query: 231 TEEEAL-TFITAIKTMMSTFGKMMVTP-VELHKRLNTKVWQAHTLAWDTIFKSVKPCIDN 288 +E +A+ T I+ + T++ G +V P V L+ L +W W+ + V+ I+ Sbjct: 2 SERDAVKTAISLVGTILGKLGVPLVGPIVSLYSTLIDVLWPGGKSQWEIFMEQVEALINQ 61 Query: 289 RLQRYSQ 295 ++ Y++ Sbjct: 62 KIAEYAR 68 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3K9V-A nrPDB 605 e-173 5W0C-A nrPDB 415 e-116 2NNH-A nrPDB 414 e-116 4GQS-A nrPDB 407 e-114 3N9Z-A nrPDB 401 e-112 1N6B-A nrPDB 399 e-111 3MZS-A nrPDB 398 e-111 4H1N-A nrPDB 382 e-106 3IBD-A nrPDB 381 e-106 3E6I-A nrPDB 377 e-105 5E58-A nrPDB 374 e-104 5E0E-A nrPDB 372 e-103 2PG7-A nrPDB 372 e-103 4ZGX-A nrPDB 363 e-100 6M7X-A nrPDB 360 e-100 6DWN-A nrPDB 358 3e-99 6B82-A nrPDB 346 1e-95 5VEU-A nrPDB 344 7e-95 5YLW-A nrPDB 342 2e-94 5UYS-A nrPDB 341 5e-94 6DA2-A nrPDB 340 1e-93 2HI4-A nrPDB 337 5e-93 4R20-A nrPDB 316 2e-86 6IQ5-A nrPDB 314 7e-86 4R1Z-A nrPDB 304 5e-83 3DL9-A nrPDB 290 1e-78 6C94-A nrPDB 288 3e-78 3TBG-A nrPDB 279 2e-75 3S79-A nrPDB 275 3e-74 4KPA-A nrPDB 274 8e-74 3QZ1-A nrPDB 259 3e-69 5VBU-A nrPDB 255 4e-68 3MDV-A nrPDB 253 1e-67 3EL3-A nrPDB 232 3e-61 3JUS-A nrPDB 225 3e-59 2WX2-A nrPDB 222 2e-58 3L4D-A nrPDB 222 3e-58 2VE3-A nrPDB 219 2e-57 6AYB-A nrPDB 215 4e-56 5FSA-A nrPDB 214 6e-56 6CR2-A nrPDB 209 3e-54 5CJE-A nrPDB 209 3e-54 2W0A-A nrPDB 206 2e-53 4WMZ-A nrPDB 203 1e-52 2X2N-A nrPDB 201 6e-52 4TRI-A nrPDB 199 2e-51 5JLC-A nrPDB 199 2e-51 6HQG-A nrPDB 198 5e-51 3MGX-A nrPDB 198 7e-51 5L94-A nrPDB 197 1e-50 2VZM-A nrPDB 195 4e-50 3RWL-A nrPDB 194 6e-50 5OFQ-A nrPDB 191 5e-49 2Y5N-A nrPDB 189 3e-48 1CPT-A nrPDB 188 5e-48 4RM4-A nrPDB 187 9e-48 2WM5-A nrPDB 186 2e-47 6A7J-A nrPDB 184 6e-47 4Z5P-A nrPDB 184 8e-47 1Z8P-A nrPDB 182 2e-46 2XKR-A nrPDB 182 3e-46 6HQW-A nrPDB 181 9e-46 3WVS-A nrPDB 180 1e-45 3R9C-A nrPDB 179 2e-45 4UBS-A nrPDB 179 2e-45 4YZR-A nrPDB 178 5e-45 6A7I-A nrPDB 177 1e-44 5LIE-A nrPDB 177 1e-44 2WIO-A nrPDB 176 2e-44 3P3Z-A nrPDB 174 7e-44 5XJN-A nrPDB 173 2e-43 5GWE-A nrPDB 172 2e-43 1GWI-A nrPDB 171 5e-43 5FYF-A nrPDB 171 6e-43 3SN5-A nrPDB 170 1e-42 3NC3-A nrPDB 169 2e-42 5L1U-A nrPDB 166 3e-41 5DQN-A nrPDB 165 3e-41 4WPZ-A nrPDB 165 3e-41 4PWV-A nrPDB 162 2e-40 3TKT-A nrPDB 162 4e-40 1F4U-A nrPDB 159 3e-39 4XE3-A nrPDB 157 9e-39 3B98-A nrPDB 154 1e-37 6DCD-A nrPDB 151 5e-37 5Z9I-A nrPDB 151 6e-37 1UE8-A nrPDB 148 5e-36 2IAG-A nrPDB 143 2e-34 5D3U-A nrPDB 138 5e-33 1WIY-A nrPDB 135 3e-32 Sequences not found previously or not previously below threshold: 3EJB-B nrPDB 185 5e-47 6CVC-A nrPDB 178 5e-45 4OQS-A nrPDB 175 3e-44 4OQR-A nrPDB 172 2e-43 6GMF-A nrPDB 172 4e-43 2Z36-A nrPDB 171 7e-43 3ABB-A nrPDB 168 4e-42 5VWS-A nrPDB 167 7e-42 4GGV-A nrPDB 167 1e-41 4JBT-A nrPDB 164 1e-40 5XNT-A nrPDB 162 3e-40 5Y1I-A nrPDB 162 3e-40 2ZBZ-A nrPDB 162 4e-40 3A50-A nrPDB 162 4e-40 4MM0-A nrPDB 161 7e-40 6GK6-A nrPDB 160 1e-39 5H1Z-A nrPDB 159 2e-39 5XW2-A nrPDB 159 2e-39 4YT3-A nrPDB 159 3e-39 6HQD-A nrPDB 159 3e-39 6B11-A nrPDB 159 4e-39 3ABA-A nrPDB 158 6e-39 5IT1-A nrPDB 157 7e-39 5FOI-A nrPDB 157 1e-38 3IVY-A nrPDB 156 2e-38 1ODO-A nrPDB 156 3e-38 6F0B-A nrPDB 154 1e-37 4Z5Q-A nrPDB 153 2e-37 5YSW-A nrPDB 153 2e-37 5EX6-C nrPDB 152 2e-37 2RFC-A nrPDB 152 3e-37 1UED-A nrPDB 151 6e-37 6G5O-A nrPDB 148 4e-36 1LG9-A nrPDB 147 1e-35 5NWS-A nrPDB 146 2e-35 6FSH-A nrPDB 146 3e-35 4TX3-A nrPDB 144 1e-34 3TYW-A nrPDB 142 3e-34 5DE9-A nrPDB 142 5e-34 1EHE-A nrPDB 141 7e-34 2X9P-A nrPDB 141 1e-33 2FR7-A nrPDB 140 1e-33 1Q5D-A nrPDB 139 3e-33 5HDI-A nrPDB 139 3e-33 2UUQ-A nrPDB 138 6e-33 3A1L-A nrPDB 136 2e-32 4DO1-A nrPDB 136 3e-32 6GII-A nrPDB 135 5e-32 6M7L-A nrPDB 134 7e-32 5LIV-A nrPDB 134 9e-32 3OFT-A nrPDB 134 1e-31 6F88-A nrPDB 134 1e-31 2WIY-A nrPDB 133 2e-31 6BLD-A nrPDB 129 3e-30 5HIW-A nrPDB 129 4e-30 4FB2-A nrPDB 129 4e-30 5KYO-A nrPDB 124 7e-29 6G71-A nrPDB 124 1e-28 3WEC-A nrPDB 120 1e-27 2NZA-A nrPDB 120 1e-27 3BUJ-A nrPDB 119 4e-27 3OO3-A nrPDB 118 5e-27 2QBO-A nrPDB 117 1e-26 5HH3-A nrPDB 114 9e-26 5OMS-A nrPDB 108 6e-24 3NV6-A nrPDB 106 2e-23 2IJ7-A nrPDB 105 7e-23 4C9K-A nrPDB 102 5e-22 6FYJ-A nrPDB 101 8e-22 5EX8-A nrPDB 99 4e-21 2RCM-A nrPDB 89 6e-18 5M0P-A nrPDB 88 7e-18 2ZQJ-A nrPDB 81 1e-15 3DBM-A nrPDB 81 2e-15 5YHJ-A nrPDB 80 3e-15 3AWQ-A nrPDB 78 9e-15 2YJN-B nrPDB 65 8e-11 3KY9-A nrPDB 32 0.44 4H3S-A nrPDB 31 1.1 1LQA-A nrPDB 30 3.0 3HGT-A nrPDB 29 4.3 3RP9-A nrPDB 29 4.4 3G6B-A nrPDB 29 4.8 5XF8-3 nrPDB 29 5.0 2TMD-A nrPDB 29 5.2 4DJD-D nrPDB 29 6.5 6CY1-A nrPDB 29 7.5 >3K9V-A nrPDB Length = 482 Score = 605 bits (1560), Expect = e-173, Method: Composition-based stats. Identities = 480/481 (99%), Positives = 480/481 (99%) Query: 34 ASRAPKEVPLCPLMTDGETRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKY 93 ASRAPKEVPLCPLMTDGETRNVT LPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKY Sbjct: 2 ASRAPKEVPLCPLMTDGETRNVTDLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKY 61 Query: 94 GQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQ 153 GQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQ Sbjct: 62 GQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQ 121 Query: 154 EWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFE 213 EWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFE Sbjct: 122 EWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFE 181 Query: 214 SICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTL 273 SICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTL Sbjct: 182 SICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTL 241 Query: 274 AWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTAN 333 AWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTAN Sbjct: 242 AWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTAN 301 Query: 334 SLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF 393 SLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF Sbjct: 302 SLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF 361 Query: 394 TTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHL 453 TTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHL Sbjct: 362 TTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHL 421 Query: 454 PFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRP 513 PFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRP Sbjct: 422 PFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRP 481 Query: 514 R 514 R Sbjct: 482 R 482 >5W0C-A nrPDB Length = 477 Score = 415 bits (1067), Expect = e-116, Method: Composition-based stats. Identities = 99/464 (21%), Positives = 193/464 (41%), Gaps = 26/464 (5%) Query: 58 LPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLE 116 PGPT P++G++L+I G+K +L K YG +F + G V L G ++ E Sbjct: 13 PPGPTPLPVIGNILQI----GIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKE 68 Query: 117 ALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK-- 174 AL R + N +G++ G++W+ +R F ++ + K Sbjct: 69 ALIDLGEEFSGRGIFP----LAERANRGFGIVFSNGKKWKEIRR-FSLMTLRNFGMGKRS 123 Query: 175 LDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEE 234 ++ ++ E +E EL + D L IC +++ KRF ++ Sbjct: 124 IEDRVQEEARCLVE---ELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNL 180 Query: 235 ALTFITAIKTMMSTFGKMMVTP---VELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQ 291 IK + S + ++ ++ + K+ + I + VK ++ Sbjct: 181 MEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDM 240 Query: 292 RYSQQPGADFLCDIYQQDH-----LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNP 346 Q FL + ++ H + + L +L A ETT+ +L + L L ++P Sbjct: 241 NNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 300 Query: 347 QAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF-TTRTLDKPTVLG 405 + ++ +E++ V+ N++P +D +MPY A + E R +P + Sbjct: 301 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR 360 Query: 406 EYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAH-LPFGIGKRMCIG 464 Y +PKGT + ++ + F + F P +L + + +PF GKR+C+G Sbjct: 361 NYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVG 420 Query: 465 RRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELP 508 LA ++L L L I+Q +++ + +P + ++ +P Sbjct: 421 EALAGMELFLFLTSILQNFNLKSL-VDPKNLDTTPVVNGFASVP 463 >2NNH-A nrPDB Length = 476 Score = 414 bits (1064), Expect = e-116, Method: Composition-based stats. Identities = 104/472 (22%), Positives = 189/472 (40%), Gaps = 28/472 (5%) Query: 58 LPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLE 116 PGPT P++G++L+I K K + + K YG +F + G V G ++ E Sbjct: 12 PPGPTPLPIIGNMLQIDVKDICK----SFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKE 67 Query: 117 ALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK-- 174 AL R + G++ G+ W+ +R F ++ + K Sbjct: 68 ALIDNGEEFSGRGNSP----ISQRITKGLGIISSNGKRWKEIRR-FSLTTLRNFGMGKRS 122 Query: 175 LDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEE 234 ++ ++ E +E EL + D L IC V+++KRF + Sbjct: 123 IEDRVQEEAHCLVE---ELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTL 179 Query: 235 ALTFITAIKTMMSTFGKMMVTPV---ELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQ 291 F + + S + ++ + + KV + L I + VK + Sbjct: 180 MKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDV 239 Query: 292 RYSQQPGADFLCDIYQQ-----DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNP 346 + FL + Q+ + + L V +L +A ETT+ +L + L L ++P Sbjct: 240 NNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHP 299 Query: 347 QAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVP-FTTRTLDKPTVLG 405 + ++ +E+ V+ +++P +D +MPY A + E R + VP + T Sbjct: 300 EVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFR 359 Query: 406 EYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPF-AHLPFGIGKRMCIG 464 Y +PKGT + + + F + + F P +L K +PF GKR+C G Sbjct: 360 NYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAG 419 Query: 465 RRLAELQLHLALCWIIQKYDIVATDNEP---VEMLHLGILVPSRELPIAFRP 513 LA ++L L L I+Q +++ + D+ + GI+ I F P Sbjct: 420 EGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIP 471 >4GQS-A nrPDB Length = 477 Score = 407 bits (1047), Expect = e-114, Method: Composition-based stats. Identities = 96/464 (20%), Positives = 189/464 (40%), Gaps = 26/464 (5%) Query: 58 LPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLE 116 PGPT P++G++L+I +K +L K YG +F + G V L G + E Sbjct: 13 PPGPTPLPVIGNILQID----IKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKE 68 Query: 117 ALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK-- 174 AL R + N +G++ G+ W+ +R F ++ + K Sbjct: 69 ALIDLGEEFSGRGHFP----LAERANRGFGIVFSNGKRWKEIRR-FSLMTLRNFGMGKRS 123 Query: 175 LDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEE 234 ++ ++ E +E EL + D L IC ++++KRF ++ Sbjct: 124 IEDRVQEEARCLVE---ELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNL 180 Query: 235 ALTFITAIKTMMSTFGKMMVTPV---ELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQ 291 I+ + + + ++ + + K+ + I + VK ++ Sbjct: 181 MEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDI 240 Query: 292 RYSQQPGADFLCDIY-----QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNP 346 + FL + QQ + + L +L A ETT+ +L + L L ++P Sbjct: 241 NNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP 300 Query: 347 QAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF-TTRTLDKPTVLG 405 + ++ +E++ V+ N++P +D +MPY A + E R +P + Sbjct: 301 EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFR 360 Query: 406 EYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINP-FAHLPFGIGKRMCIG 464 Y +PKGT + + + F + F P +L + +PF GKR+C+G Sbjct: 361 NYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVG 420 Query: 465 RRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELP 508 LA ++L L L +I+Q +++ + +P ++ ++ +P Sbjct: 421 EGLARMELFLFLTFILQNFNLKSL-IDPKDLDTTPVVNGFASVP 463 >3N9Z-A nrPDB Length = 487 Score = 401 bits (1031), Expect = e-112, Method: Composition-based stats. Identities = 139/463 (30%), Positives = 223/463 (48%), Gaps = 11/463 (2%) Query: 59 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEAL 118 PG W L + + G K H + +KYG I+R KLG+ +SV++ P + L Sbjct: 14 PGDNGWLNLYH---FWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALL 70 Query: 119 YRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKK 178 +++E +P+R I PW AY + G+++ + W++ R A +++M P Sbjct: 71 FKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPL 130 Query: 179 INEVLADFLERMDELCDERGR---IPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEA 235 ++ V DF+ + + G D+ +L +++FESI V++ +R G+L++ EA Sbjct: 131 LDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEA 190 Query: 236 LTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQ 295 FI AI M T M+ P +L + TK W+ H AWD IF N Q Sbjct: 191 QRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQ 250 Query: 296 QPGA-----DFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQR 350 + L + +S +++ A VTE+ V+TT+ +L W LY ++RN + Q Sbjct: 251 KGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQD 310 Query: 351 RLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALP 410 L EV + Q A L+ +P LKA +KE++RL P R L VL +Y +P Sbjct: 311 MLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIP 370 Query: 411 KGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAEL 470 T++ + LG F D F P RWL K+K I F +L FG G R C+GRR+AEL Sbjct: 371 AKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAEL 430 Query: 471 QLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRP 513 ++ + L +++ + + V IL+P + + F P Sbjct: 431 EMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWP 473 >1N6B-A nrPDB Length = 473 Score = 399 bits (1026), Expect = e-111, Method: Composition-based stats. Identities = 99/465 (21%), Positives = 198/465 (42%), Gaps = 23/465 (4%) Query: 58 LPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLE 116 PGPT +P++G++L+I K +L ++ + YG +F + LG +V L G ++ E Sbjct: 12 PPGPTPFPIIGNILQID----AKDISKSLTKFSECYGPVFTVYLGMKPTVVLHGYEAVKE 67 Query: 117 ALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK-- 174 AL R + + + G+ + W+ +R F ++ + K Sbjct: 68 ALVDLGEEFAGRGSVPILEKVS----KGLGIAFSNAKTWKEMRR-FSLMTLRNFGMGKRS 122 Query: 175 LDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEE 234 ++ +I E +E EL D L IC V++ RF +E + Sbjct: 123 IEDRIQEEARCLVE---ELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKL 179 Query: 235 ALTFITAIKTMMSTFGKMMVTPV---ELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQ 291 + ++ + + + ++ + ++ + + + I + VK Sbjct: 180 MESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDV 239 Query: 292 RYSQQPGADFLCDIYQQDHL--SKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQ 349 + FL + Q+++L + + L AV++L A ETT+ +L + L L ++P+ Sbjct: 240 NNPRDFIDCFLIKMEQENNLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPEVA 299 Query: 350 RRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF-TTRTLDKPTVLGEYA 408 R+ +E++ V+ +++P +D MPY A + E R +P + + Y Sbjct: 300 ARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRNYF 359 Query: 409 LPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPF-AHLPFGIGKRMCIGRRL 467 +PKGT + + + E F + F P +L + +PF GKRMC+G L Sbjct: 360 IPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGEGL 419 Query: 468 AELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFR 512 A ++L L L I+Q + + + EP ++ ++ +P +++ Sbjct: 420 ARMELFLFLTSILQNFKLQSL-VEPKDLDITAVVNGFVSVPPSYQ 463 >3MZS-A nrPDB Length = 486 Score = 398 bits (1023), Expect = e-111, Method: Composition-based stats. Identities = 134/462 (29%), Positives = 234/462 (50%), Gaps = 10/462 (2%) Query: 59 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEAL 118 PG W L + + G ++ H E +KYG I+R KLG+ +SV++ P + L Sbjct: 16 PGDNGWLNLYH---FWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHL 72 Query: 119 YRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKK 178 ++ E ++P+R +I PW AY + + G++ + W++ R ++M P I Sbjct: 73 FKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPL 132 Query: 179 INEVLADFLERMDELCDERGR---IPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEA 235 +N V DF+ + + ++G + D+ +L ++FESI V++ +R G+L++ EA Sbjct: 133 LNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEA 192 Query: 236 LTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQ 295 FI A+ M T ++ P EL++ TK W+ H AWDTIF + + Q + Sbjct: 193 QKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRR 252 Query: 296 Q----PGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRR 351 + L + + + + +++ A +TE+ V TT+ +L W LY ++R+ Q Sbjct: 253 KTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEM 312 Query: 352 LLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPK 411 L +EV + + ++ L+ +P LKA +KE++RL P R + VL +Y +P Sbjct: 313 LREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPA 372 Query: 412 GTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQ 471 T++ + +G F KF P RWL K+K + F +L FG G R C+GRR+AEL+ Sbjct: 373 KTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELE 432 Query: 472 LHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRP 513 + L L I++ + + V+ + IL P + + + FRP Sbjct: 433 MTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRP 474 >4H1N-A nrPDB Length = 479 Score = 382 bits (980), Expect = e-106, Method: Composition-based stats. Identities = 109/478 (22%), Positives = 191/478 (39%), Gaps = 38/478 (7%) Query: 58 LPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLE 116 PGP+ P+LG+LL++ KG L+ + +KYG +F + LGS V L G+ ++ E Sbjct: 12 PPGPSPLPVLGNLLQMDRKGLLR----SFLRLREKYGDVFTVYLGSRPVVVLCGTDAIRE 67 Query: 117 ALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK-- 174 AL A R +I A D + YG++ G+ W+ +R F M+ + K Sbjct: 68 ALVDQAEAFSGRGKI----AVVDPIFQGYGVIFANGERWRALRR-FSLATMRDFGMGKRS 122 Query: 175 LDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEE 234 ++++I E +E EL +G + D + + IC +++ KRF Sbjct: 123 VEERIQEEARCLVE---ELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRL 179 Query: 235 ALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYS 294 F + + S ++ EL H + + + + I ++++ Sbjct: 180 LDLFFQSFSLISSFSSQVF----ELFSGFLKYFPGTHRQIYRNL-QEINTFIGQSVEKHR 234 Query: 295 Q-----QPGADFLCDIYQ--------QDHLSKKELYAAVTELQLAAVETTANSLMWILYN 341 P + + + L V L A ETT+ +L + Sbjct: 235 ATLDPSNPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLL 294 Query: 342 LSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDK 400 + + P R+ +E++ V+ ++ P +D MPY A + E RL +PF T+ K Sbjct: 295 MLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTK 354 Query: 401 PTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPF-AHLPFGIGK 459 T Y +PK T + FE + F P +L + +PF +GK Sbjct: 355 DTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGK 414 Query: 460 RMCIGRRLAELQLHLALCWIIQKYDI---VATDNEPVEMLHLGILVPSRELPIAFRPR 514 R+C+G +A +L L I+Q + I V ++ + G+ I F R Sbjct: 415 RICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNVPPSYQIRFLAR 472 >3IBD-A nrPDB Length = 476 Score = 381 bits (978), Expect = e-106, Method: Composition-based stats. Identities = 105/467 (22%), Positives = 187/467 (40%), Gaps = 38/467 (8%) Query: 69 SLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEALYRTESAHPQ 127 +LL++ +G LK + + +KYG +F + LG V L G ++ EAL A Sbjct: 23 NLLQMDRRGLLK----SFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSG 78 Query: 128 RLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK--LDKKINEVLAD 185 R +I A D YG++ G W+ +R F M+ + K ++++I E Sbjct: 79 RGKI----AMVDPFFRGYGVIFANGNRWKVLRR-FSVTTMRDFGMGKRSVEERIQEEAQC 133 Query: 186 FLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTM 245 +E EL +G + D + IC +++ KRF +E + F + Sbjct: 134 LIE---ELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLI 190 Query: 246 MSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQ-----PGAD 300 S FG++ EL AH + + + + I + ++++ + P Sbjct: 191 SSVFGQLF----ELFSGFLKHFPGAHRQVYKNL-QEINAYIGHSVEKHRETLDPSAPRDL 245 Query: 301 FLCDIYQ--------QDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRL 352 + S + L L A ETT+ +L + + + P R+ Sbjct: 246 IDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERV 305 Query: 353 LQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDKPTVLGEYALPK 411 +E++ V+ ++ P D MPY +A + E R + +P + + T Y +PK Sbjct: 306 YREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPK 365 Query: 412 GTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINP-FAHLPFGIGKRMCIGRRLAEL 470 T + L FE F P+ +L + A +PF +GKR+C+G +A Sbjct: 366 DTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARA 425 Query: 471 QLHLALCWIIQKYDI---VATDNEPVEMLHLGILVPSRELPIAFRPR 514 +L L I+Q + + VA ++ + G+ I F PR Sbjct: 426 ELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 472 >3E6I-A nrPDB Length = 476 Score = 377 bits (969), Expect = e-105, Method: Composition-based stats. Identities = 102/473 (21%), Positives = 195/473 (41%), Gaps = 29/473 (6%) Query: 58 LPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLE 116 PGP P++G+L ++ LK + +++G +F + +GS V + G ++ E Sbjct: 12 PPGPFPLPIIGNLFQLE----LKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKE 67 Query: 117 ALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKL- 175 AL + R ++ + A+RD G++ G W+ +R F ++ + K Sbjct: 68 ALLDYKDEFSGRGDLPAFHAHRDR-----GIIFNNGPTWKDIRR-FSLTTLRNYGMGKQG 121 Query: 176 -DKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEE 234 + +I LE L +G+ D + I +L+ K F ++ Sbjct: 122 NESRIQREAHFLLEA---LRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL 178 Query: 235 ALTFITAIKTMMSTFGKMMVTPVELHKRL---NTKVWQAHTLAWDTIFKSVKPCIDNRLQ 291 F + + + ++ L + KV + + + + VK + Sbjct: 179 MYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDP 238 Query: 292 RYSQQPGADFLCDIYQQDHLSK-----KELYAAVTELQLAAVETTANSLMWILYNLSRNP 346 + L ++ ++ H ++ + V +L A ETT+ +L + L L + P Sbjct: 239 NCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYP 298 Query: 347 QAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF-TTRTLDKPTVLG 405 + + +L +E+ V+ ++ P +D + MPY+ A + E R VP + T+ Sbjct: 299 EIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFR 358 Query: 406 EYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHL-PFGIGKRMCIG 464 Y +PKGTV+ + F D KF+PE +L + K + PF GKR+C G Sbjct: 359 GYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAG 418 Query: 465 RRLAELQLHLALCWIIQKYDIVATDNE---PVEMLHLGILVPSRELPIAFRPR 514 LA ++L L LC I+Q +++ + + +H+G + PR Sbjct: 419 EGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 471 >5E58-A nrPDB Length = 493 Score = 374 bits (961), Expect = e-104, Method: Composition-based stats. Identities = 104/469 (22%), Positives = 180/469 (38%), Gaps = 42/469 (8%) Query: 69 SLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEALYRTESAHPQ 127 +LL++ G L ++ +KYG +F + LG V L G+ ++ EAL A Sbjct: 42 NLLQMDRGGFL----NSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSG 97 Query: 128 RLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK--LDKKINEVLAD 185 R I K YG++ G+ W+ +R F M+ + K ++ +I E Sbjct: 98 RGTIAVIKPVIGD----YGMIFSNGERWKVLRR-FSLATMRDFGMGKRSVEDRIQEEAQC 152 Query: 186 FLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTM 245 +E EL +G D + IC +++ +R+ ++ F M Sbjct: 153 LVE---ELQKSQGAPLDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLM 209 Query: 246 MSTFGKMMVTPVELHKRL---NTKVWQAHTLAWDTIFKSV------------KPCIDNRL 290 S ++ K + ++ + D + +SV + ID L Sbjct: 210 SSFSSQVFELFSGFMKYFPGAHRQITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYL 269 Query: 291 QRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQR 350 R ++ Q + L +V L A ETT+ +L + + + P Sbjct: 270 LRMEKEKSN-------QHTEFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAE 322 Query: 351 RLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDKPTVLGEYAL 409 ++ +E+ V+ ++ P ED MPY A + E R + P + K T+ Y L Sbjct: 323 KVQKEIDQVIGSHRLPTLEDRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLL 382 Query: 410 PKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPF-AHLPFGIGKRMCIGRRLA 468 PK T + FE F P+ +L + A +PF IGKR+C+G +A Sbjct: 383 PKNTEVYPILSSALHDPQYFEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIA 442 Query: 469 ELQLHLALCWIIQKYDI---VATDNEPVEMLHLGILVPSRELPIAFRPR 514 +L L I+Q + + VA + + GI + I+F R Sbjct: 443 RNELFLFFTTILQNFSVSSSVAPKDIDLSPKESGIGKVPQTYQISFLAR 491 >5E0E-A nrPDB Length = 463 Score = 372 bits (955), Expect = e-103, Method: Composition-based stats. Identities = 101/469 (21%), Positives = 182/469 (38%), Gaps = 42/469 (8%) Query: 69 SLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEALYRTESAHPQ 127 +LL++ G L ++ +KYG +F + LG V L G+ ++ EAL A Sbjct: 14 NLLQMDRGGFL----NSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSG 69 Query: 128 RLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK--LDKKINEVLAD 185 R I A + YG++ G+ W+ +R F M+ + K ++++I E Sbjct: 70 RGTI----AVVEPIFRGYGVVFANGERWKALRR-FSLVTMRDFGMGKRSVEERIQEEARC 124 Query: 186 FLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTM 245 +E E +G D + IC +++ +RF + F + + Sbjct: 125 LVE---EFRKSQGAPLDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLI 181 Query: 246 MSTFGKMMVTP---VELHKRLNTKVWQAHTLAWDTIFKSV------------KPCIDNRL 290 S ++ ++ + ++ + D I +SV + ID L Sbjct: 182 SSFSSQVFELFSGFLKYFPGTHRQISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYL 241 Query: 291 QRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQR 350 R ++ Q + L +V L A ET++ +L + + + P Sbjct: 242 LRMEKEKSN-------QHTEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAE 294 Query: 351 RLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDKPTVLGEYAL 409 ++ +E+ V+ ++ P ED MPY +A + E R + +P + K T+ Y L Sbjct: 295 KVQKEIDQVIGSHRLPTLEDRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLL 354 Query: 410 PKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPF-AHLPFGIGKRMCIGRRLA 468 PK T + FE F P+ +L + A +PF IGKR+C+G +A Sbjct: 355 PKNTEVYPILSSALHDPQYFEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIA 414 Query: 469 ELQLHLALCWIIQKYDI---VATDNEPVEMLHLGILVPSRELPIAFRPR 514 +L L I+Q + + VA + + G + I F R Sbjct: 415 RNELFLFFTTILQNFSLSSPVAPKDIDLSPKESGFGKVPQTYQICFLAR 463 >2PG7-A nrPDB Length = 476 Score = 372 bits (954), Expect = e-103, Method: Composition-based stats. Identities = 101/478 (21%), Positives = 200/478 (41%), Gaps = 38/478 (7%) Query: 58 LPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLE 116 PGPT P +G+ L++ ++ +++L + ++YG +F + LG V L G ++ E Sbjct: 12 PPGPTPLPFIGNYLQL----NTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVRE 67 Query: 117 ALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK-- 174 AL R E +A D + YG++ G+ +++R F ++ + K Sbjct: 68 ALVDQAEEFSGRGE----QATFDWVFKGYGVVFSNGERAKQLRR-FSIATLRDFGVGKRG 122 Query: 175 LDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEE 234 ++++I E ++ L G D L++ I +++ RF KE Sbjct: 123 IEERIQEEAGFLIDA---LRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSL 179 Query: 235 ALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYS 294 + + ++ G++ + K L QA + + ++ I +++ Sbjct: 180 LRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQ-----LLQGLEDFIAKKVEHNQ 234 Query: 295 Q-----QPGADFLCDIYQ--------QDHLSKKELYAAVTELQLAAVETTANSLMWILYN 341 + P + + K L +L + ET + +L + Sbjct: 235 RTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLL 294 Query: 342 LSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF-TTRTLDK 400 L ++P+ + ++ +E+ V+ N+ P+ ED MPY++A + E R +P R + K Sbjct: 295 LMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKK 354 Query: 401 PTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPF-AHLPFGIGK 459 T ++ LPKGT + + F + F P+ +L ++ + A +PF IGK Sbjct: 355 DTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGK 414 Query: 460 RMCIGRRLAELQLHLALCWIIQKYDIVATDNE---PVEMLHLGILVPSRELPIAFRPR 514 R C G LA ++L L ++Q + + ++ + V H+G R ++F PR Sbjct: 415 RNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 472 >4ZGX-A nrPDB Length = 489 Score = 363 bits (932), Expect = e-100, Method: Composition-based stats. Identities = 141/485 (29%), Positives = 234/485 (48%), Gaps = 18/485 (3%) Query: 34 ASRAPKEVPLCPLMTDGETRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKY 93 A+RAP+ V P + PG W LL+I+ + G + H + + ++ Sbjct: 5 AARAPRTV--LPF------EAMPQHPG-NRWL---RLLQIWREQGYEHLHLEMHQTFQEL 52 Query: 94 GQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQ 153 G IFR LG V + P +E L + +S HP R+ ++PW AYR HR G+ +L G Sbjct: 53 GPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGP 112 Query: 154 EWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDE--LCDERGRIP-DLYSELNKW 210 EW+ R ++ P + + ++ V DF + + + L + RG + D+ + + Sbjct: 113 EWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHY 172 Query: 211 SFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQA 270 + E+ L L+ +R GL+ +L F+ A++ M + ++M P L + ++ KVW+ Sbjct: 173 TIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKE 232 Query: 271 HTLAWDTIFKSVKPCIDNRLQRY---SQQPGADFLCDIYQQDHLSKKELYAAVTELQLAA 327 H AWD IF+ CI Q Q + ++ + LS + + A EL + Sbjct: 233 HFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGS 292 Query: 328 VETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRL 387 V+TTA L+ L+ L+RNP Q+ L QE + + +P L+A LKE++RL Sbjct: 293 VDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRL 352 Query: 388 TPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKI 447 P F R + VL Y +P GT++ + LG + F ++ P+RWL Sbjct: 353 YPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSG 412 Query: 448 NPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSREL 507 F H+PFG G R C+GRRLAE ++ L L +++ + + E ++M++ IL P Sbjct: 413 RNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSP 472 Query: 508 PIAFR 512 + FR Sbjct: 473 LLTFR 477 >6M7X-A nrPDB Length = 484 Score = 360 bits (925), Expect = e-100, Method: Composition-based stats. Identities = 132/449 (29%), Positives = 218/449 (48%), Gaps = 6/449 (1%) Query: 70 LLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRL 129 LL+I+ + G + H + + ++ G IFR LG V + P +E L + +S HP R+ Sbjct: 29 LLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRM 88 Query: 130 EIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLER 189 ++PW AYR HR G+ +L G EW+ R +++ P + + ++ V DF + Sbjct: 89 SLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQA 148 Query: 190 MDE--LCDERGRIP-DLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMM 246 + + L + RG + D+ + ++ E+ L L+ +R GL+ +L F+ A++ M Sbjct: 149 LKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMF 208 Query: 247 STFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRY---SQQPGADFLC 303 + ++M P L + + KVW+ H AWD IF+ CI Q Q + Sbjct: 209 KSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVA 268 Query: 304 DIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDN 363 ++ LS + A EL +V+TT L+ L+ L+RNP Q+ L QE + Sbjct: 269 ELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASI 328 Query: 364 QTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLG 423 + +P L+A LKE++RL P F R VL Y +P GT++ + LG Sbjct: 329 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLG 388 Query: 424 SSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKY 483 + F ++ P+RWL F H+PFG G R C+GRRLAE ++ L L +++ Sbjct: 389 RNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 448 Query: 484 DIVATDNEPVEMLHLGILVPSRELPIAFR 512 + E ++M++ IL PS + FR Sbjct: 449 QVETLTQEDIKMVYSFILRPSMFPLLTFR 477 >6DWN-A nrPDB Length = 491 Score = 358 bits (919), Expect = 3e-99, Method: Composition-based stats. Identities = 100/471 (21%), Positives = 201/471 (42%), Gaps = 41/471 (8%) Query: 52 TRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-G 110 ++ + + PGP WPL+G +L + K H L+ ++YG + ++++GS V L G Sbjct: 7 SKGLKNPPGPWGWPLIGHMLTLG-----KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 61 Query: 111 SPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPV 170 ++ +AL R R ++ + + ++ ++ G W R Q +K Sbjct: 62 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPD--SGPVWAARRRLAQNG-LKSF 118 Query: 171 EIMK---------LDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYE 221 I L++ +++ + + EL G + Y + IC + + Sbjct: 119 SIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHF-NPYRYVVVSVTNVICAICFG 177 Query: 222 KRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPV---------ELHKRLNTKVWQAHT 272 +R+ +E ++ + P+ K LN K + Sbjct: 178 RRYDHNHQELLSLVNL-NNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQ 236 Query: 273 LAWDTIFKSVKPC----IDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAV 328 +K+ + I + L + Q+ D ++ LS +++ V +L A Sbjct: 237 KMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV----QLSDEKIINIVLDLFGAGF 292 Query: 329 ETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLT 388 +T ++ W L L NP+ QR++ +E+ +V+ ++ PR D ++PY++A + E+ R + Sbjct: 293 DTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHS 352 Query: 389 PSVPFTT-RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKI 447 VPFT + + T L + +PKG + +N + + + + +F PER+L + I Sbjct: 353 SFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAI 412 Query: 448 NPFAH---LPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEM 495 + + FG+GKR CIG +A ++ L L ++Q+ + V+M Sbjct: 413 DKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDM 463 >6B82-A nrPDB Length = 509 Score = 346 bits (887), Expect = 1e-95, Method: Composition-based stats. Identities = 106/488 (21%), Positives = 204/488 (41%), Gaps = 43/488 (8%) Query: 52 TRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLG- 110 R+ SLP + P++GSL+ + H + KKYG ++ + +GS + + Sbjct: 22 NRSPPSLP---SLPIIGSLMSLVSD---SPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNN 75 Query: 111 SPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILE-GQEWQRVRSAFQKKLMKP 169 E L + R + + + W+ R L Sbjct: 76 HHHAKEILIKKGKIFAGRPRTVTTDLLTR---DGKDIAFADYSSTWKFHRKMVHGALCMF 132 Query: 170 VEIMKLDKKINEVLADFLERMDE-LCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQ 228 + I +++ M E L + + DL EL + +C + + + Sbjct: 133 ---GEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSSYKRGD 189 Query: 229 KETEEEA-----LTFITAIKTMMSTFGKMMVTP----------VELHKRLNTKVWQAHTL 273 E E + A +++ F + + P + + +L K ++ H + Sbjct: 190 AEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLRILRQCISIRDKLLQKKYEEHKV 249 Query: 274 AW-DTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTA 332 + D + + + + R +R S+ + + L++ + V E+ A VETT Sbjct: 250 TYSDNVQRDLLDALL-RAKRSSENNNSST-----RDVGLTEDHVLMTVGEIFGAGVETTT 303 Query: 333 NSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVP 392 +L W + L NPQ QR++ +E+ S + + P+ D N+PYL+A + E MR+ P P Sbjct: 304 TTLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSP 363 Query: 393 FTT-RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKK---IN 448 + + +GEY + KGT + +N L E +++ F P R+L +E Sbjct: 364 LLIPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCP 423 Query: 449 PFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLH--LGILVPSRE 506 ++LPFG G R+C+G LA+++L L L WI+Q++ + +P+ L G+++ ++ Sbjct: 424 SGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKK 483 Query: 507 LPIAFRPR 514 + + R Sbjct: 484 FKVVAKVR 491 >5VEU-A nrPDB Length = 480 Score = 344 bits (881), Expect = 7e-95, Method: Composition-based stats. Identities = 121/479 (25%), Positives = 208/479 (43%), Gaps = 41/479 (8%) Query: 57 SLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLE 116 +PGPT PLLG++L ++ GL K E +KKYG+++ G + + P ++ Sbjct: 16 GIPGPTPLPLLGNVLS--YRQGLWKFD---TECYKKYGKMWGTYEGQLPVLAITDPDVIR 70 Query: 117 ALYRTE--SAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPV--EI 172 + E S R + P + + + E +EW+R+RS E+ Sbjct: 71 TVLVKECYSVFTNRRSLGPVGFMKS------AISLAEDEEWKRIRSLLSPTFTSGKLKEM 124 Query: 173 MKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETE 232 + + +VL L R E +G+ L +S + I + L + Sbjct: 125 FPIIAQYGDVLVRNLRREAE----KGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQD 180 Query: 233 E------EALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCI 286 + L F +S +TPV + LN ++ T+ + + KSV Sbjct: 181 PFVESTKKFLKFGFLDPLFLSIILFPFLTPV--FEALNVSLFPKDTINF--LSKSVNRMK 236 Query: 287 DNRLQRYSQQPGADFLCDIYQQDH---------LSKKELYAAVTELQLAAVETTANSLMW 337 +RL Q+ DFL + + LS EL A A ETT++ L + Sbjct: 237 KSRLND-KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSF 295 Query: 338 ILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRT 397 LY L+ +P Q++L +E+ +VLP+ P + + M YL + E++RL P RT Sbjct: 296 TLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERT 355 Query: 398 LDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGI 457 K + +PKG+++ + T L + + +FRPER+ +K+ I+P+ + PFG Sbjct: 356 CKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGT 415 Query: 458 GKRMCIGRRLAELQLHLALCWIIQKYDIVATDNE--PVEMLHLGILVPSRELPIAFRPR 514 G R CIG R A + + LAL ++Q + P+++ G+L P + + + R Sbjct: 416 GPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 474 >5YLW-A nrPDB Length = 495 Score = 342 bits (878), Expect = 2e-94, Method: Composition-based stats. Identities = 110/472 (23%), Positives = 194/472 (41%), Gaps = 25/472 (5%) Query: 58 LPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSL-LE 116 PGP +P++G++L++ H A+ K+YG + + LGS +V + SP + E Sbjct: 29 PPGPFPYPIVGNMLQLG-----ANPHQVFAKLSKRYGPLMSIHLGSLYTVIVSSPEMAKE 83 Query: 117 ALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLD 176 L+R R + A DH + G + + EW+ +R ++++ + Sbjct: 84 ILHRHGQVFSGRTIAQAVHAC-DHDKISMGFLPV-ASEWRDMRKICKEQMFSNQSMEASQ 141 Query: 177 KKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEAL 236 + L L+ + + C + GR D+ + + L+ + + E Sbjct: 142 GLRRQKLQQLLDHVQK-CSDSGRAVDIREAAFITTLNLMSATLFSSQATEFDSKATMEFK 200 Query: 237 TFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQ 296 I + T++ P+ L V + + + + ++ ++ RL+ Sbjct: 201 EIIEGVATIVGVPNFADYFPI-LRPFDPQGVKRRADVFFGKLLAKIEGYLNERLESKRAN 259 Query: 297 PG----ADFL---CDIYQQDH--LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQ 347 P DFL DI Q + L + +L + +T S+ W + L NP Sbjct: 260 PNAPKKDDFLEIVVDIIQANEFKLKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPD 319 Query: 348 AQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVP-FTTRTLDKPTVLGE 406 RL E++SV D + + +PYL+A +KE MR+ P P R + + Sbjct: 320 KMARLKAELKSVAGDEKIVDESAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNG 379 Query: 407 YALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQK--EKKINPFAHLPFGIGKRMCIG 464 Y +PKGT + +N +G + D F PER+L + K + LPFG G+R+C G Sbjct: 380 YLIPKGTQILINAYAIGRDPSIWTDPETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPG 439 Query: 465 RRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPS---RELPIAFRP 513 LA LH+A ++ +D D+ H G L R +P+ P Sbjct: 440 MPLATRILHMATATLVHNFDWKLEDDSTAAADHAGELFGVAVRRAVPLRIIP 491 >5UYS-A nrPDB Length = 494 Score = 341 bits (874), Expect = 5e-94, Method: Composition-based stats. Identities = 101/479 (21%), Positives = 207/479 (43%), Gaps = 42/479 (8%) Query: 63 NWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSL-LEALYRT 121 + PL+GSL + G + H+ + KKYG I+ +++G+ +V +G L E L + Sbjct: 15 SLPLVGSLPFLPRHGHM---HNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKK 71 Query: 122 ESAHPQRLEIKPWKAYRDHRNEAYGLMILE-GQEWQRVRSAFQKKLMKPVEIMK-LDKKI 179 R ++ ++R G+ + G WQ R M + K D+K+ Sbjct: 72 GKDFSGRPQMATLDIASNNRK---GIAFADSGAHWQLHRRLA----MATFALFKDGDQKL 124 Query: 180 NEVLADFLERM-DELCDERGRIPDLYSELNKWSFESICLVLYEKRF-------------- 224 +++ + + D L G+ D+ + I L+ + + Sbjct: 125 EKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYN 184 Query: 225 -GLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAW--DTIFKS 281 G++ +++ + + +K + + + + V++ L K+ + + + D+I Sbjct: 185 EGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNM 244 Query: 282 VKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYN 341 + + ++ + G D ++ +H + + ++ A VETT + + W L Sbjct: 245 LDTLMQAKMNSDNGNAGPDQDSELLSDNH-----ILTTIGDIFGAGVETTTSVVKWTLAF 299 Query: 342 LSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTLDK 400 L NPQ +++L +E+ + ++TP D + L+A ++E +RL P P + Sbjct: 300 LLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANV 359 Query: 401 PTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKK---INPFAHLPFGI 457 + +GE+A+ KGT + +N L +E + +F PER+L ++LPFG Sbjct: 360 DSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGA 419 Query: 458 GKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLH--LGILVPSRELPIAFRPR 514 G R CIG LA +L L + W++Q++D+ D+ + L ++ + + R Sbjct: 420 GPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVR 478 >6DA2-A nrPDB Length = 487 Score = 340 bits (871), Expect = 1e-93, Method: Composition-based stats. Identities = 119/478 (24%), Positives = 204/478 (42%), Gaps = 38/478 (7%) Query: 57 SLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLE 116 +PGPT P LG++L + KG E HKKYG+++ G + + P +++ Sbjct: 17 GIPGPTPLPFLGNILS-YHKGFCMFD----MECHKKYGKVWGFYDGQQPVLAITDPDMIK 71 Query: 117 ALYRTE--SAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPV--EI 172 + E S R P + + I E +EW+R+RS E+ Sbjct: 72 TVLVKECYSVFTNRRPFGPVGFMKS------AISIAEDEEWKRLRSLLSPTFTSGKLKEM 125 Query: 173 MKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETE 232 + + + +VL L R E G+ L +S + I + L + Sbjct: 126 VPIIAQYGDVLVRNLRREAE----TGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQD 181 Query: 233 EEALTFITAIKTMM--STFGKMMVTP--VELHKRLNTKVWQAHTLAWDTIFKSVKPCIDN 288 ++ F + V P + + + LN V+ + + KSVK ++ Sbjct: 182 PFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNF--LRKSVKRMKES 239 Query: 289 RLQRYSQQPGADFLCDIYQQDH---------LSKKELYAAVTELQLAAVETTANSLMWIL 339 RL+ +Q+ DFL + + LS EL A A ETT++ L +I+ Sbjct: 240 RLED-TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIM 298 Query: 340 YNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLD 399 Y L+ +P Q++L +E+ +VLP+ P + + M YL + E++RL P R Sbjct: 299 YELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCK 358 Query: 400 KPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEK-KINPFAHLPFGIG 458 K + +PKG V+ + + L + + KF PER+ +K K I+P+ + PFG G Sbjct: 359 KDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSG 418 Query: 459 KRMCIGRRLAELQLHLALCWIIQKYDIVATDNE--PVEMLHLGILVPSRELPIAFRPR 514 R CIG R A + + LAL ++Q + P+++ G+L P + + + R Sbjct: 419 PRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 476 >2HI4-A nrPDB Length = 495 Score = 337 bits (865), Expect = 5e-93, Method: Composition-based stats. Identities = 101/477 (21%), Positives = 194/477 (40%), Gaps = 56/477 (11%) Query: 53 RNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGS- 111 + + S P P WPLLG +L + K H L+ ++YG + ++++GS + L Sbjct: 13 KGLKSPPEPWGWPLLGHVLTLG-----KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRL 67 Query: 112 PSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVE 171 ++ +AL R R ++ D ++ + G W R Q + Sbjct: 68 DTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTD--SGPVWAARRRLAQNA-LNTFS 124 Query: 172 IMK---------LDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEK 222 I L++ +++ + R+ EL G D Y+++ I + + + Sbjct: 125 IASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHF-DPYNQVVVSVANVIGAMCFGQ 183 Query: 223 RFGLLQKETEEEALTFITAIKTMMST---------FGKMMVTPVEL----------HKRL 263 F E+ +E L+ + + T F + P Sbjct: 184 HF----PESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF 239 Query: 264 NTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTEL 323 K Q H +D SV+ + + P A + + ++++ V ++ Sbjct: 240 LQKTVQEHYQDFDK--NSVRDITGALFKHSKKGPRA-------SGNLIPQEKIVNLVNDI 290 Query: 324 QLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKE 383 A +T ++ W L L P+ QR++ +E+ +V+ + PR D +PYL+A + E Sbjct: 291 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILE 350 Query: 384 SMRLTPSVPFTT-RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQ 442 + R + +PFT + + T L + +PK + +N + + +ED +FRPER+L Sbjct: 351 TFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 410 Query: 443 KEK----KINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEM 495 + K + FG+GKR CIG LA+ ++ L L ++Q+ + V++ Sbjct: 411 ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDL 467 >4R20-A nrPDB Length = 486 Score = 316 bits (809), Expect = 2e-86, Method: Composition-based stats. Identities = 92/453 (20%), Positives = 171/453 (37%), Gaps = 32/453 (7%) Query: 81 KQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPS-LLEALYRTESAHPQRLEIKPWKAYRD 139 H + +YG +F + G ++ + + E L + R ++ Sbjct: 40 PPHLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQ 99 Query: 140 HRNEAYGLMILE-GQEWQRVRSAFQKK-LMKPVEIMKLDKKINEVLADFLERMDELCDER 197 + + W+ R + KL + E E EL R Sbjct: 100 G---GKDIAFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCE---ELQACR 153 Query: 198 GRIPDLYSELNKWSFESICLVLYEKRFGLLQKETE-----EEALTFITAIKTMMSTFGKM 252 G+ DL L + IC +++ + E + + + A ++ F + Sbjct: 154 GQSSDLSVVLMRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIFPWL 213 Query: 253 MVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQ---- 308 + P + KRL V L + + + K +P + Q Sbjct: 214 RIFPNKDLKRLKECVSIRDQLLYKKLLEHKKSLT-------PGEPRDLLDALLIGQQRGS 266 Query: 309 ---DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQT 365 D +++ + E A VETT+ +L+W + L +PQ Q R+ E+ + ++ Sbjct: 267 GGADDITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRP 326 Query: 366 PRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTLDKPTVLGEYALPKGTVLTLNTQVLGS 424 P D ++P L A L E MR+ P P + T LG +++PKGT + +N + Sbjct: 327 PCLSDRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHH 386 Query: 425 SEDNFEDSHKFRPERWLQKEKKINP-FAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKY 483 +++ +F PER+L+ K + LPFG G R+C+G LA ++L L + +Q++ Sbjct: 387 DPKHWDQPEQFNPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRF 446 Query: 484 DIVATDNEPVEMLH--LGILVPSRELPIAFRPR 514 + L G+++ + PR Sbjct: 447 SFSCPSEASLPDLQGRFGVVLQPERYTVTVTPR 479 >6IQ5-A nrPDB Length = 463 Score = 314 bits (804), Expect = 7e-86, Method: Composition-based stats. Identities = 102/461 (22%), Positives = 193/461 (41%), Gaps = 31/461 (6%) Query: 80 KKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEALYRTESAHPQRLEIKPWKAYR 138 + H + A ++YG +F+++LGS V L G ++ +AL + SA R ++ Sbjct: 1 QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVS 60 Query: 139 DHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINE--VLADFLERMDELCDE 196 R+ A+G + W+ R A + +++ E VL++ E + L Sbjct: 61 GGRSMAFGHY---SEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLV-- 115 Query: 197 RGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTP 256 RG + + + ++ V+ FG + E ++ + T G + Sbjct: 116 RGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVD 175 Query: 257 VELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQ--QPGA---DFLCDIY----- 306 V + + ++ + ++ I ++ R+ + +PGA D + Sbjct: 176 VMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEK 235 Query: 307 --------QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQS 358 L + + A +T++ A+ +T + +L W+L +R P Q R+ E+ Sbjct: 236 KAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQ 295 Query: 359 VLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTLDKPTVLGEYALPKGTVLTL 417 V+ ++ P D N+PY+ A L E+MR + VP T T + Y +PK TV+ + Sbjct: 296 VVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFV 355 Query: 418 NTQVLGSSEDNFEDSHKFRPERWLQKEKKINP---FAHLPFGIGKRMCIGRRLAELQLHL 474 N + + + F P R+L K+ IN + F +GKR CIG L+++QL L Sbjct: 356 NQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFL 415 Query: 475 ALCWIIQKYDIVATDNEPVEMLHL-GILVPSRELPIAFRPR 514 + + + D A NEP +M G+ + + + R Sbjct: 416 FISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLR 456 >4R1Z-A nrPDB Length = 439 Score = 304 bits (779), Expect = 5e-83, Method: Composition-based stats. Identities = 90/439 (20%), Positives = 181/439 (41%), Gaps = 37/439 (8%) Query: 101 LGSFDSVHLG-SPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILE-GQEWQRV 158 +GS + + E L + R + + + W+ Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTR---DGKDIAFADYSSTWKFH 57 Query: 159 RSAFQKKLMKPVEIMKLDKKINEVLADFLERMDE-LCDERGRIPDLYSELNKWSFESICL 217 R L + I +++ M E L + + DL EL + +C Sbjct: 58 RKMVHGALCMF---GEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCA 114 Query: 218 VLYEKRFGLLQKETEEEA-----LTFITAIKTMMSTFGKMMVTP----------VELHKR 262 + + + E E + A +++ F + + P + + + Sbjct: 115 LCFNSSYKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLTILRQCISIRDK 174 Query: 263 LNTKVWQAHTLAW-DTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVT 321 L K ++ H + + D + + + + R +R S+ + + L++ + V Sbjct: 175 LLQKKYEEHKVTYSDNVQRDLLDALL-RAKRSSENNNSST-----RDVGLTEDHVLMTVG 228 Query: 322 ELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACL 381 ++ A VETT L W + L NPQ QR++ +E+ S + + P+ D N+PYL+A + Sbjct: 229 DIFGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATI 288 Query: 382 KESMRLTPSVPFTT-RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERW 440 +E +R+ P P + + +GEY + KGT + +N L + +++ F P R+ Sbjct: 289 REVLRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRF 348 Query: 441 LQKEKK---INPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLH 497 L +E ++LPFG G R+C+G LA+++L L L WI+Q++ + +P+ L Sbjct: 349 LNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQ 408 Query: 498 --LGILVPSRELPIAFRPR 514 G+++ ++ + + R Sbjct: 409 GKFGVVLQPKKFKVVAKVR 427 >3DL9-A nrPDB Length = 479 Score = 290 bits (741), Expect = 1e-78, Method: Composition-based stats. Identities = 93/440 (21%), Positives = 172/440 (39%), Gaps = 28/440 (6%) Query: 82 QHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEALYRTESAHPQRLEIKPWKAYRDH 140 H + + + YG+IF + LG +V L G + E L R + + Sbjct: 36 PHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMT-- 93 Query: 141 RNEAYGLMILEGQEWQRVRSAFQKKLMK-PVEIMKLDKKINEVLADFLERMDELCDERGR 199 L G+ W R + KI E F + ++ +GR Sbjct: 94 -KMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIE---TYKGR 149 Query: 200 IPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKT-------MMSTFGKM 252 D + L+++ +RF + + F ++ + + F + Sbjct: 150 PFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWI 209 Query: 253 MVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQ---- 308 + P H++L ++ + +D + + ++ NR + Q +L ++ Q Sbjct: 210 GILPFGKHQQL----FRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDP 265 Query: 309 -DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPR 367 SK+ L +V EL +A ETT N L W + ++ P Q ++ +E+ ++ N P Sbjct: 266 SSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS 325 Query: 368 AEDLRNMPYLKACLKESMRLTPSVPF-TTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSE 426 +D MPY +A L E +R VP + V+ Y++PKGT + N + E Sbjct: 326 WDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDE 385 Query: 427 DNFEDSHKFRPERWLQKEKKI-NPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI 485 + D F PER+L A +PF +G+R C+G LA +++ L ++Q++ + Sbjct: 386 KYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 445 Query: 486 VATDN--EPVEMLHLGILVP 503 ++ L P Sbjct: 446 HFPHELVPDLKPRLGMTLQP 465 >6C94-A nrPDB Length = 497 Score = 288 bits (738), Expect = 3e-78, Method: Composition-based stats. Identities = 107/453 (23%), Positives = 199/453 (43%), Gaps = 37/453 (8%) Query: 55 VTSLPGP-TNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSF-DSVHLGSP 112 + S PGP T+W L G LEI G L D + + +++ + +G F +++ P Sbjct: 21 MDSFPGPPTHW-LFGHALEIQKTGSL----DKVVTWTQQFPYAHPLWVGQFIGFLNIYEP 75 Query: 113 SLLEALY-RTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVE 171 +A+Y R + P + + GL++L+G +W + R KL+ P Sbjct: 76 DYAKAVYSRGDPKAPDVYDFFL-------QWIGKGLLVLDGPKWFQHR-----KLLTPGF 123 Query: 172 IMKLDKKINEVLADFLERMDELCDER---GRIPDLYSELNKWSFESICLVLYEK-RFGLL 227 + K + AD M E +++ G+ D++S++ + +++ + K GL Sbjct: 124 HYDVLKPYVAIFADSTRIMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSGLN 183 Query: 228 QKETEE----EALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVK 283 +++ LT + + + + + H R + +A D + + K Sbjct: 184 HRDSSYYVAVSELTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACRAAHDHTDRVIRQRK 243 Query: 284 PCIDN-----RLQRYSQQPGADFLCDIYQQD--HLSKKELYAAVTELQLAAVETTANSLM 336 + + ++Q D L D+ + LS +L A V +TT + + Sbjct: 244 AALQDEKEREKIQNRRHLDFLDILLDVRGESGVQLSDTDLRAEVDTFMFEGHDTTTSGIS 303 Query: 337 WILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTR 396 W LY ++ P+ Q+R +EV+ +L D + + EDL M YL C+KE RL P VP R Sbjct: 304 WFLYCMALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVYR 363 Query: 397 TLDKPTVL-GEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKK-INPFAHLP 454 L KP +LP G++++L+ L + D + D F P R+ + +P+A +P Sbjct: 364 QLSKPVSFVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAFIP 423 Query: 455 FGIGKRMCIGRRLAELQLHLALCWIIQKYDIVA 487 F G R CIG++ A ++ + + +++ Sbjct: 424 FSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSV 456 >3TBG-A nrPDB Length = 479 Score = 279 bits (714), Expect = 2e-75, Method: Composition-based stats. Identities = 98/448 (21%), Positives = 167/448 (37%), Gaps = 27/448 (6%) Query: 86 LAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEA 144 + +++G +F ++L V L G ++ EAL R + P + Sbjct: 36 FDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPV-PITQILGFGPRS 94 Query: 145 YGLMILE-GQEWQRVRSAFQKKLMKPVEIMK--LDKKINEVLADFLERMDELCDERGRIP 201 G+ + G W+ R F ++ + + K L++ + E A + GR Sbjct: 95 QGVFLARYGPAWREQRR-FSVSTLRNLGLGKKSLEQWVTEEAACL---CAAFANHSGRPF 150 Query: 202 DLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMV-TPVELH 260 L+K I + +RF +K +++ PV LH Sbjct: 151 RPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH 210 Query: 261 -KRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDH--------- 310 L KV + + + ++R+ QP D + Sbjct: 211 IPALAGKVLRFQKAFLTQLDE---LLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESS 267 Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED 370 + + L V +L A + TT+ +L W L + +P QRR+ QE+ V+ + P D Sbjct: 268 FNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGD 327 Query: 371 LRNMPYLKACLKESMRLTPSVPFT-TRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNF 429 +MPY A + E R VP T + + + +PKGT L N + E + Sbjct: 328 QAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW 387 Query: 430 EDSHKFRPERWLQKEKK-INPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVAT 488 E +F PE +L + + P A LPF G+R C+G LA ++L L ++Q + Sbjct: 388 EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVP 447 Query: 489 DNEPVEMLH--LGILVPSRELPIAFRPR 514 +P H LV + PR Sbjct: 448 TGQPRPSHHGVFAFLVSPSPYELCAVPR 475 >3S79-A nrPDB Length = 503 Score = 275 bits (703), Expect = 3e-74, Method: Composition-based stats. Identities = 92/486 (18%), Positives = 203/486 (41%), Gaps = 56/486 (11%) Query: 53 RNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSP 112 +S+PGP +G L+ Y++ YG+ R+ + +++ + Sbjct: 42 EGTSSIPGPGYCMGIGPLISHGRF-LWMGIGSACNYYNRVYGEFMRVWISGEETLIISKS 100 Query: 113 SLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQE-----------WQRVRSA 161 S + I Y GL + E W+ R Sbjct: 101 SSM-------------FHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPF 147 Query: 162 FQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYE 221 F K L P ++++ E L L+R++E+ +E G + D+ + L + ++ Sbjct: 148 FMKALSGP-GLVRMVTVCAESLKTHLDRLEEVTNESGYV-DVLTLLRRVMLDT------- 198 Query: 222 KRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKS 281 L+ +E A+ + I+ + +++ P K + +++ + + + + Sbjct: 199 SNTLFLRIPLDESAI--VVKIQGYFDAWQALLIKPDIFFKI--SWLYKKYEKSVKDLKDA 254 Query: 282 VKPCIDNRLQRYSQQPG----ADFLCDIYQQDH---LSKKELYAAVTELQLAAVETTANS 334 ++ I + +R S + DF ++ + L+++ + + E+ +AA +T + S Sbjct: 255 IEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVS 314 Query: 335 LMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFT 394 L ++L+ ++++P + +++E+Q+V+ + + + +D++ + ++ + ESMR P V Sbjct: 315 LFFMLFLIAKHPNVEEAIIKEIQTVIGE-RDIKIDDIQKLKVMENFIYESMRYQPVVDLV 373 Query: 395 TRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLP 454 R + V+ Y + KGT + LN + E F ++F E + K + P Sbjct: 374 MRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENF---AKNVPYRYFQP 429 Query: 455 FGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVE---MLHLGILVPSRE---LP 508 FG G R C G+ +A + + L +++++ + + VE +H L P L Sbjct: 430 FGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLE 489 Query: 509 IAFRPR 514 + F PR Sbjct: 490 MIFTPR 495 >4KPA-A nrPDB Length = 494 Score = 274 bits (700), Expect = 8e-74, Method: Composition-based stats. Identities = 102/463 (22%), Positives = 193/463 (41%), Gaps = 35/463 (7%) Query: 55 VTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSL 114 + +P P + L +L + K L + + G+IF+ + + +L S L Sbjct: 26 IKEMPQPKTFGELKNLPLL----NTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRL 81 Query: 115 LEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVR----SAFQKKLMKPV 170 ++ ES + L + K RD + + W++ +F ++ MK Sbjct: 82 IKEACD-ESRFDKNLS-QALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGY 139 Query: 171 EIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKE 230 M +D + L ER++ DE +P+ ++ + + ++I L + RF ++ Sbjct: 140 HAMMVDIAVQ--LVQKWERLN--ADEHIEVPE---DMTRLTLDTIGLCGFNYRFNSFYRD 192 Query: 231 TEEEALT-FITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNR 289 +T + A+ M+ + P + N + +Q + + V I +R Sbjct: 193 QPHPFITSMVRALDEAMNKLQRA--NPDDPAYDENKRQFQEDIKVMNDL---VDKIIADR 247 Query: 290 LQRYSQQPGADFLCDIY------QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLS 343 + S + D L + + L + + + +A ETT+ L + LY L Sbjct: 248 --KASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLV 305 Query: 344 RNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTV 403 +NP ++ +E VL D P + ++ + Y+ L E++RL P+ P + + TV Sbjct: 306 KNPHVLQKAAEEAARVLVD-PVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTV 364 Query: 404 LGE-YALPKGTVLTLNTQVLGSSEDNF-EDSHKFRPERWLQKEKKINPFAHLPFGIGKRM 461 LG Y L KG L + L + + +D +FRPER+ + I A PFG G+R Sbjct: 365 LGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERF-ENPSAIPQHAFKPFGNGQRA 423 Query: 462 CIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPS 504 CIG++ A + L L +++ +D N +++ L P Sbjct: 424 CIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPE 466 >3QZ1-A nrPDB Length = 496 Score = 259 bits (661), Expect = 3e-69, Method: Composition-based stats. Identities = 95/479 (19%), Positives = 185/479 (38%), Gaps = 51/479 (10%) Query: 61 PTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEALY 119 P P LL+ L +K G ++R++LG + V L ++ EA+ Sbjct: 31 PPLVPGFLHLLQ-------PNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMI 83 Query: 120 RTESAHPQRLEIKPWKAYRDH-RNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKK 178 R R +I +K ++ + G L W+ + + L+ ++ Sbjct: 84 RKWVDFAGRPQIPSYKLVSQRCQDISLGDYSL---LWKAHKKLTRSALL-LGTRSSMEPW 139 Query: 179 INEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTF 238 ++++ +F ERM + G + E + + IC + + + L + Sbjct: 140 VDQLTQEFCERM---RVQAGAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDL 196 Query: 239 ITAIK----TMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKS-----------VK 283 + ++ + P RL + + + + + Sbjct: 197 MKTWDHWSIQILDMVPFLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMT 256 Query: 284 PCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLS 343 + + R + G L + ++ +V +L + ETTA++L W + L Sbjct: 257 DYMLQGVGRQRVEEGPG---------QLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLL 307 Query: 344 RNPQAQRRLLQEVQSVLPDN---QTPRAEDLRNMPYLKACLKESMRLTPSVPF-TTRTLD 399 +P+ QRRL +E+ L +D +P L A + E +RL P VP Sbjct: 308 HHPEIQRRLQEELDRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTT 367 Query: 400 KPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGK 459 +P+ + Y +P+G V+ N Q E +E H+FRP+R+L+ + L FG G Sbjct: 368 RPSSIFGYDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANPSA---LAFGCGA 424 Query: 460 RMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHL----GILVPSRELPIAFRPR 514 R+C+G LA L+L + L ++Q + ++ + L G+ + + + +PR Sbjct: 425 RVCLGESLARLELFVVLARLLQAFTLLPPPVGALPSLQPDPYCGVNLKVQPFQVRLQPR 483 >5VBU-A nrPDB Length = 476 Score = 255 bits (650), Expect = 4e-68, Method: Composition-based stats. Identities = 96/467 (20%), Positives = 189/467 (40%), Gaps = 34/467 (7%) Query: 65 PLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEALYRTES 123 P LL+ L +K+G I+R+ LG D V L ++ EA+ + + Sbjct: 16 PGFLHLLQ-------PDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWA 68 Query: 124 AHPQRLEIKPWKAY-RDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEV 182 R E +K R++ + + G L W+ + + L+ + ++ + ++ Sbjct: 69 DFAGRPEPLTYKLVSRNYPDLSLGDYSL---LWKAHKKLTRSALLLGI-RDSMEPVVEQL 124 Query: 183 LADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEK-----RFGLLQKETEEEALT 237 +F ERM + G + E + + IC + + + +E L Sbjct: 125 TQEFCERM---RAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLK 181 Query: 238 FITAIK-TMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQ 296 + ++ + P +RL + + + + + + + + + Sbjct: 182 TWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDY 241 Query: 297 --PGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQ 354 G L + ++ A +L + ETTAN+L W + L +P+ Q+RL + Sbjct: 242 MLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQE 301 Query: 355 EVQSVLPDN---QTPRAEDLRNMPYLKACLKESMRLTPSVPF-TTRTLDKPTVLGEYALP 410 E+ L +D +P L A + E +RL P VP +P+ + Y +P Sbjct: 302 ELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIP 361 Query: 411 KGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAEL 470 +GTV+ N Q E +E H+F P+R+L+ K L FG G R+C+G LA L Sbjct: 362 EGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRA---LAFGCGARVCLGEPLARL 418 Query: 471 QLHLALCWIIQKYDIVATDNEPV---EMLHLGILVPSRELPIAFRPR 514 +L + L ++Q + ++ + + + H +++ + + +PR Sbjct: 419 ELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPR 465 >3MDV-A nrPDB Length = 456 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 92/436 (21%), Positives = 175/436 (40%), Gaps = 13/436 (2%) Query: 84 DTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNE 143 D ++ KKYG + R+ + SV + SP ++ + + + + R Sbjct: 14 DVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLF 73 Query: 144 AYGLMIL-EGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPD 202 GL+ + W + R + ++ L + NE +E ++ D + Sbjct: 74 GQGLVSECNYERWHKQRRVIDLAFSRS-SLVSLMETFNEKAEQLVEILEAKADGQ-TPVS 131 Query: 203 LYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKR 262 + L + + + + +L A+K M+ T + Sbjct: 132 MQDMLTYTAMDILAKAAFGMETSML----LGAQKPLSQAVKLMLEGITASRNTLAKFLPG 187 Query: 263 LNTKVWQAHTLAWDTIFKSVKPCIDNRLQ--RYSQQPGADFLCDIYQQDHLSKKE--LYA 318 K + + + + + + R + + ++ AD L I + + ++ + L Sbjct: 188 -KRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLD 246 Query: 319 AVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLK 378 +A ET+AN L + + LSR P+ RL EV V+ + EDL + YL Sbjct: 247 NFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLS 306 Query: 379 ACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPE 438 LKES+RL P T R L++ T++ +P T L +T V+G + FED F P+ Sbjct: 307 QVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPD 366 Query: 439 RWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHL 498 R+ K F + PF +G R CIG++ A++++ + + ++Q+ + + + Sbjct: 367 RFGPGAPKPR-FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQ 425 Query: 499 GILVPSRELPIAFRPR 514 L P + RPR Sbjct: 426 ATLKPLDPVLCTLRPR 441 >3EL3-A nrPDB Length = 467 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 104/479 (21%), Positives = 181/479 (37%), Gaps = 49/479 (10%) Query: 51 ETRNVTSLPGP---------TNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKL 101 ETR + P PLLG W+ L + + +G + R+KL Sbjct: 9 ETRAPAAPGAPELREPPVAGGGVPLLGH----GWR--LARDPLAFMSQLRDHGDVVRIKL 62 Query: 102 GSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSA 161 G + +P L AL H P + G+ G +R R Sbjct: 63 GPKTVYAVTNPELTGALALNPDYH----IAGPLWESLEGLLGKEGVATANGPLHRRQRRT 118 Query: 162 FQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYE 221 Q + I + E ER G+ D SE + + L Sbjct: 119 IQPAF-RLDAIPAYGPIMEEEAHALTERWQ-----PGKTVDATSESFRVAVRVAARCLL- 171 Query: 222 KRFGLLQKETEEE----ALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDT 277 R + + E A F + M+ G + P+ ++R N + H L + Sbjct: 172 -RGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEI 230 Query: 278 IFKSVKPCIDNRLQRYSQQPGADFLCDIYQQ-----DHLSKKELYAAVTELQLAAVETTA 332 I + +R S Q D L + + D + ++E++ V + ET A Sbjct: 231 IAE----------RRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIA 280 Query: 333 NSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVP 392 +++MW+L L+ +P+ R+ EV++V + ED+R + + + E+MRL P+V Sbjct: 281 STIMWLLQALADHPEHADRIRDEVEAVTGG-RPVAFEDVRKLRHTGNVIVEAMRLRPAVW 339 Query: 393 FTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWL-QKEKKINPFA 451 TR + LG Y +P G + + + +++D+ +F P+RWL ++ + +A Sbjct: 340 VLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYA 399 Query: 452 HLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIA 510 PF GKR C + QL L + KY + + +GI + +L + Sbjct: 400 MKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSN-DAVRVGITLRPHDLLVR 457 >3JUS-A nrPDB Length = 461 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 94/472 (19%), Positives = 186/472 (39%), Gaps = 38/472 (8%) Query: 54 NVTSLPGPT-NWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSP 112 V S P P LG + K + L ++KYG +F + +L Sbjct: 9 GVKSPPYIFSPIPFLGHAIAFG-----KSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGS 63 Query: 113 SLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAF--QKKLMKPV 170 L+ + + ++ Y +G +G + F QKK++K Sbjct: 64 DAAALLF-----NSKNEDLNAEDVYSRLTTPVFG----KGVAYDVPNPVFLEQKKMLKSG 114 Query: 171 EIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKE 230 + K+ ++ + E E G +++ L++ + L+ K ++ + Sbjct: 115 LNIAHFKQHVSIIEKETKEYFESWGESGE-KNVFEALSELIILTASHCLHGK---EIRSQ 170 Query: 231 TEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRL 290 E+ + S ++ + L + +AH D +K+++ Sbjct: 171 LNEKVAQLYADLDGGFSHAAWLLPGWLPLPS--FRRRDRAHREIKDIFYKAIQK------ 222 Query: 291 QRYSQQPGADFLCDIYQQDH-----LSKKELYAAVTELQLAAVETTANSLMWILYNLSRN 345 +R SQ+ D L + + L+ E+ + L LA T++ + W+ + L+R+ Sbjct: 223 RRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARD 282 Query: 346 PQAQRRLLQEVQSVLPDNQTPRAED-LRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVL 404 Q++ E ++V +N P D L+++ L C+KE++RL P + R P + Sbjct: 283 KTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTV 342 Query: 405 GEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKI-NPFAHLPFGIGKRMCI 463 Y +P G + ++ V +D++ + F P+R+LQ FA++PFG G+ CI Sbjct: 343 AGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCI 402 Query: 464 GRRLAELQLHLALCWIIQKYDIVATDNE-PVEMLHLGILVPSRELPIAFRPR 514 G A +Q+ +++ Y+ D P I P + I ++ R Sbjct: 403 GENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPV-IRYKRR 453 >2WX2-A nrPDB Length = 473 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 80/468 (17%), Positives = 159/468 (33%), Gaps = 43/468 (9%) Query: 52 TRNVTSLP-GPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHK--KYGQIFRMKLGSFDSVH 108 T T P P P LG +++ K + + + K G +F + +G Sbjct: 12 TTRPTDPPVYPVTVPFLGHIVQFG-----KNPLEFMQRCKRDLKSG-VFTISIGGQRVTI 65 Query: 109 LGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKL-- 166 +G P + R EI + +G + + R+R Sbjct: 66 VGDP------HEHSRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPYPRMREQLNFLAEE 119 Query: 167 MKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEK--RF 224 + + I + F M E E + +L + + C L+ + R Sbjct: 120 LTIAKFQNFVPAIQHEVRKF---MAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRK 176 Query: 225 GLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKP 284 L + + +++ ++ P+ R + I + Sbjct: 177 RLNARHFAQLLSKMESSLIPAAVFMPWLLRLPLPQSAR-----CREARAELQKILGEIIV 231 Query: 285 CIDNRLQRYSQQPGADFLCDIYQQ-----DHLSKKELYAAVTELQLAAVETTANSLMWIL 339 + + +D L + + +S E+ + A T+ + W + Sbjct: 232 A-REKEEASKDNNTSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSM 290 Query: 340 YNLSR--NPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRT 397 +L N + +L +E+ Q + MP+ + C++ES+R P + R Sbjct: 291 LHLMHPKNKKWLDKLHKEIDEF--PAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVMRM 348 Query: 398 LDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGI 457 + +G Y +PKG ++ + + E+ F + + PER + + A + FG Sbjct: 349 VKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDG-----AFIGFGA 403 Query: 458 GKRMCIGRRLAELQLHLALCWIIQKYDIVAT-DNEPVEMLHLGILVPS 504 G CIG++ A LQ+ L ++YD D P H ++ P+ Sbjct: 404 GVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPT 451 >3L4D-A nrPDB Length = 453 Score = 222 bits (566), Expect = 3e-58, Method: Composition-based stats. Identities = 77/453 (16%), Positives = 157/453 (34%), Gaps = 37/453 (8%) Query: 65 PLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESA 124 P +G +++ K + + KKYG IF M + +G +++ Sbjct: 13 PFVGHIIQFG-----KDPLGFMLKAKKKYGGIFTMNICGNRITVVGD------VHQHSKF 61 Query: 125 HPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKL--MKPVEIMKLDKKINEV 182 R EI + +G + + R+R + + I Sbjct: 62 FTPRNEILSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTVAKFQNFAPSIQHE 121 Query: 183 LADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEK--RFGLLQKETEEEALTFIT 240 + F M ++ ++ + + + C L+ + R L ++ + + Sbjct: 122 VRKF---MKANWNKDEGEINILDDCSAMIINTACQCLFGEDLRKRLDARQFAQLLAKMES 178 Query: 241 AIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGAD 300 + ++ P+ R + I + + + +D Sbjct: 179 CLIPAAVFLPWILKLPLPQSYR-----CRDARAELQDILSEI-IIAREKEEAQKDTNTSD 232 Query: 301 FLCDIY-----QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLS--RNPQAQRRLL 353 L + +S+ E+ + A T+ + W L +L RN + +L Sbjct: 233 LLAGLLGAVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLH 292 Query: 354 QEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGT 413 QE+ Q + MP+ + C +ES+R P + R + KP +G+Y +P+G Sbjct: 293 QEIDEF--PAQLNYDNVMEEMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGD 350 Query: 414 VLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLH 473 ++ + + E+ F + ++ PER K+ A FG G CIG + LQ+ Sbjct: 351 IIACSPLLSHQDEEAFPNPREWNPER----NMKLVDGAFCGFGAGVHKCIGEKFGLLQVK 406 Query: 474 LALCWIIQKYDIVATDNEPVEMLHLGILVPSRE 506 L +++ YD P H ++ P+ Sbjct: 407 TVLATVLRDYDFELLGPLPEPNYHTMVVGPTAS 439 >2VE3-A nrPDB Length = 444 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 98/463 (21%), Positives = 174/463 (37%), Gaps = 37/463 (7%) Query: 54 NVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPS 113 ++ PG P LG L G K + +++G IF+ +L + + + Sbjct: 10 SLPIPPGDFGLPWLGETLNFLNDGDFGK------KRQQQFGPIFKTRLFGKNVIFISGAL 63 Query: 114 LLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIM 173 L+ E + + + E R R + P + Sbjct: 64 ANRFLFTKEQE-----TFQATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFLPRTLD 118 Query: 174 KLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEE 233 K++ ++ +LE + Y +L + +F+ + ++ + Sbjct: 119 SYLPKMDGIVQGYLE-----QWGKANEVIWYPQLRRMTFDVAATLFMGEKVSQN-PQLFP 172 Query: 234 EALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRY 293 T+I + P+ L L K +A L + ++ I R Q+ Sbjct: 173 WFETYIQG----------LFSLPIPLPNTLFGKSQRARAL----LLAELEKIIKARQQQP 218 Query: 294 -SQQPGADFLCDIYQQDH--LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQR 350 S++ L ++ LS EL + L A ET ++L L ++ + Sbjct: 219 PSEEDALGILLAARDDNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRE 278 Query: 351 RLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALP 410 R+ QE Q+ L +Q AE L+ MPYL L+E +RL P V R L + + P Sbjct: 279 RVRQE-QNKLQLSQELTAETLKKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQGFHFP 337 Query: 411 KGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKI--NPFAHLPFGIGKRMCIGRRLA 468 KG +++ + D + D KF PER+ PFAH+PFG G R C+G+ A Sbjct: 338 KGWLVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEFA 397 Query: 469 ELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAF 511 L++ L +IQ++D + +E++ P L + Sbjct: 398 RLEMKLFATRLIQQFDWTLLPGQNLELVVTPSPRPKDNLRVKL 440 >6AYB-A nrPDB Length = 466 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 80/460 (17%), Positives = 168/460 (36%), Gaps = 24/460 (5%) Query: 61 PTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYR 120 P P +GS + K + + KKYG +F + + L P +L+ ++ Sbjct: 16 PNLIPYVGSFVSF-----AKNPVQFIIDNSKKYGDVFTATILGKEMTFLNHPKILDTFFK 70 Query: 121 TESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKIN 180 A L ++ + + + E R Q K + + Sbjct: 71 ---ATDNELSLRDVYRFMRPVFGTGVVYDADSTE----RMMEQVKFVSSGLTTARFRVFV 123 Query: 181 EVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFIT 240 ++ D + + G + D+ + + L +++ E+ Sbjct: 124 DIFEDEIAHKVKELGPEGTV-DVAELMADLIIFTASRCLLG---DEVRQYLSEK--NLGK 177 Query: 241 AIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGAD 300 + + L K +A + + + +R + D Sbjct: 178 LYHDIDDGISPLSFFYPSLPAPKRDKARKAVGEIFQELLDKRREEHKKHPERLLDESKMD 237 Query: 301 FLCDIYQQDHLSKKEL-----YAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQE 355 + + Q + +EL + A T++ + W L N+ N + ++ +E Sbjct: 238 VVDHLLTQKYKDGQELTDVHRIGILIAGLFAGQHTSSITSSWTLMNVISNKKVLEKVRKE 297 Query: 356 VQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVL 415 + ++ ++ + + M YL+AC+KE++R+ P + R KP +Y +PKG +L Sbjct: 298 QEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPLIMIMRMARKPRECEQYIIPKGNIL 357 Query: 416 TLNTQVLGSSEDNFEDSHKFRPERWLQ-KEKKINPFAHLPFGIGKRMCIGRRLAELQLHL 474 ++ V G D + + F PER + KE + + +PFG G+ CIG A LQ+ Sbjct: 358 VVSPSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGAVPFGAGRHKCIGENFALLQVKS 417 Query: 475 ALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRPR 514 + +++ +D+ P ++ PS + ++ R Sbjct: 418 IISILLRYFDMEYIGKIPDPSYTSLVVGPSPPTRMRYKLR 457 >5FSA-A nrPDB Length = 490 Score = 214 bits (546), Expect = 6e-56, Method: Composition-based stats. Identities = 90/503 (17%), Positives = 175/503 (34%), Gaps = 69/503 (13%) Query: 56 TSLPGPTNW-PLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKL-GSFDSVHLGSPS 113 + P W P GS ++ ++ +KYG +F L G +V+LG P Sbjct: 4 KTPPLVFYWIPWFGSAASYG-----QQPYEFFESCRQKYGDVFSFMLLGKIMTVYLG-PK 57 Query: 114 LLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGL-MILEGQEWQRV-RSAFQKKLMKPVE 171 E ++ + + ++ +AY+ +G +I + + + + F K + Sbjct: 58 GHEFVF-----NAKLSDVSAEEAYKHLTTPVFGTGVIYDCPNSRLMEQKKFAKFALTTDS 112 Query: 172 IMKLDKKINEVL-----ADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGL 226 + KI E + D ++ E + E+ ++ L+ Sbjct: 113 FKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTA---SRSLFG---DE 166 Query: 227 LQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCI 286 +++ + + + + + H A I + I Sbjct: 167 MRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRD-------AAQKKISATYMKEI 219 Query: 287 DNRLQRYSQQPGADFLCDIYQQD------HLSKKELYAAVTELQLAAVETTANSLMWILY 340 R +R P D + + ++ +E+ + + + T+A++ W L Sbjct: 220 KLRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLL 279 Query: 341 NLSRNPQAQRRLLQEVQSVL----PDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTR 396 +L P Q + QEV +L D EDL+ +P + +KE++R+ + R Sbjct: 280 HLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFR 339 Query: 397 TLDKPTVLGE--YALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKIN------ 448 + P + E Y +PKG + ++ +SE F++ F P RW K N Sbjct: 340 KVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNS 399 Query: 449 ---------------PFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDN--E 491 +LPFG G+ CIG + A +QL L + D Sbjct: 400 SDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRW-TIDGYKV 458 Query: 492 PVEMLHLGILVPSRELPIAFRPR 514 P +++P+ I + R Sbjct: 459 PDPDYSSMVVLPTEPAEIIWEKR 481 >6CR2-A nrPDB Length = 477 Score = 209 bits (531), Expect = 3e-54, Method: Composition-based stats. Identities = 84/494 (17%), Positives = 170/494 (34%), Gaps = 60/494 (12%) Query: 56 TSLPGPTNW-PLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFR-MKLGSFDSVHLGSPS 113 + P +W P +GS + + + KYG IF + LG +V+LG+ Sbjct: 4 KTPPVVFHWFPFIGSTISYGI-----DPYKFFFDCRAKYGDIFTFILLGKKTTVYLGT-- 56 Query: 114 LLEALYRTESAHPQRLEIKPWKA---YRDHRNEAYG-LMILEGQEWQRV-RSAFQKKLMK 168 + +++ A Y +G ++ + + + + F K + Sbjct: 57 -------KGNDFILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKYGLT 109 Query: 169 PVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQ 228 + I + + F++ +G + D+ + + + + L K ++ Sbjct: 110 SDALRSYVPLITDEVESFVKNSPAFQGHKG-VFDVCKTIAEITIYTASRSLQGK---EVR 165 Query: 229 KETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDN 288 + + + + M+ H R + T + I I Sbjct: 166 SKFDSTFAELYHNLDMGFAPINFMLPWAPLPHNRKRDAAQRKLTETYMEI-------IKA 218 Query: 289 RLQRYSQQPGAD----FLCDIYQ-QDHLSKKELYAAVTELQLAAVETTANSLMWILYNLS 343 R Q S++ D + +Y+ + +E+ + L +A +++++ WI+ L+ Sbjct: 219 RRQAGSKKDSEDMVWNLMSCVYKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLA 278 Query: 344 RNPQAQRRLLQEVQSVLPDNQTPRAED-LRNMPYLKACLKESMRLTPSVPFTTRTLDKPT 402 P L QE VL + P D L+ + +KE++RL + R + P Sbjct: 279 TRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPM 338 Query: 403 VLGE--YALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEK--------------- 445 + Y +P + + V SE++F + ++ P RW + Sbjct: 339 AVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVDYGYGL 398 Query: 446 --KINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNE---PVEMLHLGI 500 K +LPFG G+ CIG + A LQL +++ + P Sbjct: 399 VSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPGVDGIPDTDYSSLF 458 Query: 501 LVPSRELPIAFRPR 514 P + F R Sbjct: 459 SKPLGRSFVEFEKR 472 >5CJE-A nrPDB Length = 393 Score = 209 bits (531), Expect = 3e-54, Method: Composition-based stats. Identities = 87/460 (18%), Positives = 164/460 (35%), Gaps = 82/460 (17%) Query: 67 LGSLLEIFWKG--GLKKQHDTLAEYHKKYGQIFRMKLGSFDS----VHLGSPSLLEALYR 120 +G+++++ G + + AE ++ G + ++ ++ + +G AL Sbjct: 1 MGNVIDLGEYGARFTEDPYPVYAELRER-GPVHWVRTPPPEAFEGWLVVGHEEARAALAD 59 Query: 121 TESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLD---K 177 + K + D L++++ E R+RS + + + +++ Sbjct: 60 --PRLSKDGTKKGLTSL-DVELMGPYLLVVDPPEHTRLRSL----VARAFTMRRVEALRP 112 Query: 178 KINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALT 237 +I E+ L+ M RGR + S IC +L + + +T Sbjct: 113 RIQEITDGLLDEML----PRGRADLVDSFAYPLPITVICELLG---------VPDIDRVT 159 Query: 238 FITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQP 297 F +++ G A A++ + + ID+ + S P Sbjct: 160 FRALSNEIVAPTGG-----------------DAELAAYERLAAYLDELIDD---KRSTAP 199 Query: 298 GADFLCDIYQ-----QDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRL 352 D L D+ + D LS +EL A L +A ETT N + ++ L +P L Sbjct: 200 ADDLLGDLIRTRAEDDDRLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAAL 259 Query: 353 LQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF-TTRTLDKPTVLGEYALPK 411 + M L ++E +R V T R + +G A+ + Sbjct: 260 RAD------------------MTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAE 301 Query: 412 GTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQ 471 G + + G D H F R P HL FG G C+G LA L+ Sbjct: 302 GDPVMIGLDAAGRDPARHPDPHVFDIHR--------APQGHLAFGHGIHYCLGAPLARLE 353 Query: 472 LHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAF 511 +AL ++++ +A D P ++ R LP+ + Sbjct: 354 ARVALRSLLERCPDLALDGPPGARPPGMLIRGVRRLPVRW 393 >2W0A-A nrPDB Length = 455 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 72/440 (16%), Positives = 153/440 (34%), Gaps = 32/440 (7%) Query: 86 LAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAY 145 + + G + +L V L E +R + + P+ Sbjct: 30 MQRVRDELGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMTPI----FGE 85 Query: 146 GLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYS 205 ++ E R + ++ ++ I D + RM E G I DL Sbjct: 86 AVVFDASPE--RRKEMLHNAALRGEQMKGHAATIE----DQVRRMIADWGEAGEI-DLLD 138 Query: 206 ELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNT 265 + + + L K+F ++ F + + L Sbjct: 139 FFAELTIYTSSACLIGKKF------RDQLDGRFAKLYHELERGTDPLAYVDP----YLPI 188 Query: 266 KVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGA-DFLCDIYQQD------HLSKKELYA 318 + ++ A + + V ++ R+ D L + S E+ Sbjct: 189 ESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEITG 248 Query: 319 AVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLK 378 + A T++ + W L L R+ A ++ E+ + D ++ LR +P L+ Sbjct: 249 MFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQLE 308 Query: 379 ACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPE 438 LKE++RL P + R + + + +G ++ + + ++F D H F P Sbjct: 309 NVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPA 368 Query: 439 RWLQKEKK--INPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVAT-DNEPVEM 495 R+ Q ++ +N + +PFG G+ C+G A +Q+ ++++Y+ E Sbjct: 369 RYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESYRN 428 Query: 496 LHL-GILVPSRELPIAFRPR 514 H ++ ++ + +R R Sbjct: 429 DHSKMVVQLAQPAAVRYRRR 448 >4WMZ-A nrPDB Length = 539 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 85/494 (17%), Positives = 170/494 (34%), Gaps = 58/494 (11%) Query: 56 TSLPGPTNW-PLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFR-MKLGSFDSVHLGSPS 113 P W P +GS + K ++ E KKYG IF + LG +V+LG P Sbjct: 54 DRPPLVFYWIPWVGSAVVYG-----MKPYEFFEECQKKYGDIFSFVLLGRVMTVYLG-PK 107 Query: 114 LLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGL-MILEGQEWQRV-RSAFQKKLMKPVE 171 E ++ + + ++ AY +G +I + + + + F K + Sbjct: 108 GHEFVF-----NAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEA 162 Query: 172 IMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKET 231 I E E D + LN+ + +I +++ + + Sbjct: 163 FKSYVPLIAE------EVYKYFRDSKN------FRLNERTTGTIDVMVTQPEMTIFTASR 210 Query: 232 EEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQ 291 + T + + + + H D K++ + ++ Sbjct: 211 SLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIK 270 Query: 292 RYSQQ---PGADFLCDIYQQD------HLSKKELYAAVTELQLAAVETTANSLMWILYNL 342 + D + + + ++ +E+ + + + T+A + WIL +L Sbjct: 271 ERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHL 330 Query: 343 SRNPQAQRRLLQEVQSVL-PDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKP 401 + P Q+ L +E VL + + L+ MP L +KE++R+ + R + K Sbjct: 331 AERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKD 390 Query: 402 TVLGE--YALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEK-------------- 445 + Y +P G + ++ ++ F ++H+F RW Sbjct: 391 MHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFG 450 Query: 446 ---KINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDN--EPVEMLHLGI 500 K +LPFG G+ CIG A QL + + I+ + P + Sbjct: 451 AISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMV 510 Query: 501 LVPSRELPIAFRPR 514 +P+ I + R Sbjct: 511 TLPTGPAKIIWEKR 524 >2X2N-A nrPDB Length = 475 Score = 201 bits (511), Expect = 6e-52, Method: Composition-based stats. Identities = 82/465 (17%), Positives = 160/465 (34%), Gaps = 39/465 (8%) Query: 55 VTSLP-GPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQ-IFRMKLGSFDSVHLGSP 112 T P P P+LG +++ K + E ++ IF + + +G P Sbjct: 15 PTDPPVYPVTVPILGHIIQFG-----KSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDP 69 Query: 113 SLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKL--MKPV 170 + R E+ + +G + + R+R + Sbjct: 70 ------HEHSRFFLPRNEVLSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTIA 123 Query: 171 EIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKE 230 + I + F M D+ +L + + + C L+ + L+K Sbjct: 124 KFQNFVPAIQHEVRKF---MAANWDKDEGEINLLEDCSTMIINTACQCLFGED---LRKR 177 Query: 231 TEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRL 290 + A F + M S+ V L K + + H + + I + Sbjct: 178 LD--ARRFAQLLAKMESSLIPAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKA 235 Query: 291 QRYSQQPG-ADFLCDIY-----QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSR 344 ++ +D L + +S E+ + A T++ + W + +L Sbjct: 236 AAVNKDSSTSDLLSGLLSAVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMH 295 Query: 345 --NPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPT 402 N + L +E++ Q + MP+ + C +ES+R P + R + Sbjct: 296 PANVKHLEALRKEIEEF--PAQLNYNNVMDEMPFAERCARESIRRDPPLLMLMRKVMADV 353 Query: 403 VLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMC 462 +G Y +PKG ++ + + E+ F + ++ PER + E A + FG G C Sbjct: 354 KVGSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPERDEKVEG-----AFIGFGAGVHKC 408 Query: 463 IGRRLAELQLHLALCWIIQKYDIVAT-DNEPVEMLHLGILVPSRE 506 IG++ LQ+ L + YD D P H ++ P+ Sbjct: 409 IGQKFGLLQVKTILATAFRSYDFQLLRDEVPDPDYHTMVVGPTAS 453 >4TRI-A nrPDB Length = 407 Score = 199 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 61/324 (18%), Positives = 112/324 (34%), Gaps = 32/324 (9%) Query: 196 ERGRIPDLYSELNKWSFESICLVLY-EKRFGLLQKETEEEALTFITAIKTMMSTFGKMMV 254 R R+ D + + I V + + + + + ++ Sbjct: 98 TRKRVMDKVDSIGRLCDTLIDAVCERGECDFVRDIAAPLPMAVIGDMLGVLPTERDMLLK 157 Query: 255 TPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQD----H 310 +L L++ V +A F + + + + +P D + + Sbjct: 158 WSDDLVCGLSSHVDEAAIQKLMDTFAAYTEFTKDVITKRRAEPTDDLFSVLVNSEVEGQR 217 Query: 311 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED 370 +S E+ + + ETT ++L L R+ L+ +V Sbjct: 218 MSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVD------------- 264 Query: 371 LRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFE 430 L ++E +R T V RTL TV L G + L + E F Sbjct: 265 -----LLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFG 319 Query: 431 DSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKY-DIVATD 489 D FR +R NP +H+ FG G C+G +LA L+L L ++++ D+ D Sbjct: 320 DPDNFRIDR--------NPNSHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLAD 371 Query: 490 NEPVEMLHLGILVPSRELPIAFRP 513 + PV + + +P+ F P Sbjct: 372 DAPVPLRPANFVSGPESMPVVFTP 395 >5JLC-A nrPDB Length = 515 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 89/495 (17%), Positives = 176/495 (35%), Gaps = 58/495 (11%) Query: 56 TSLPGPTNW-PLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKL-GSFDSVHLGSPS 113 P W P +GS + K ++ + KKYG IF L G +V+LG P Sbjct: 36 DRPPLVFYWIPWVGSAIPYGTK-----PYEFFEDCQKKYGDIFSFMLLGRIMTVYLG-PK 89 Query: 114 LLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGL-MILEGQEWQRV-RSAFQKKLMKPVE 171 E ++ + + ++ AY +G +I + + + + F K + Sbjct: 90 GHEFIF-----NAKLADVSAEAAYSHLTTPVFGKGVIYDCPNHRLMEQKKFVKGALTKEA 144 Query: 172 IMKLDKKINEVL-ADFLERMDELCDERGR-IPDLYSELNKWSFESICLVLYEKRFGLLQK 229 ++ I E + F + +E I D+ + + + L K ++ Sbjct: 145 FVRYVPLIAEEIYKYFRNSKNFKINENNSGIVDVMVSQPEMTIFTASRSLLGK---EMRD 201 Query: 230 ETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNR 289 + + + + + + + H R QA + + ++ K Sbjct: 202 KLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQQAISGTYMSLIKE-------- 253 Query: 290 LQRYSQQPGADFLCDIY------QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLS 343 + + D + ++ ++ +E+ + + + T+A + W L +L+ Sbjct: 254 RREKNDIQNRDLIDELMKNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLA 313 Query: 344 RNPQAQRRLLQEVQSVL-PDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPT 402 P Q L QE VL D + +DL+NMP L +KE++RL + R + + Sbjct: 314 ERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLFRKVMRDV 373 Query: 403 VLGE--YALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKIN------------ 448 + Y +P+ + ++ E+ F ++F RW + Sbjct: 374 AIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFG 433 Query: 449 ------PFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIV-ATDNEPVEMLHL--G 499 +LPFG G+ CIG A QL + + I+ T+ E V Sbjct: 434 AISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTEGETVPPSDFTSM 493 Query: 500 ILVPSRELPIAFRPR 514 + +P+ I + R Sbjct: 494 VTLPTAPAKIYWEKR 508 >6HQG-A nrPDB Length = 425 Score = 198 bits (503), Expect = 5e-51, Method: Composition-based stats. Identities = 56/282 (19%), Positives = 106/282 (37%), Gaps = 39/282 (13%) Query: 236 LTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQ 295 LTF + + T G + T E H+ L + T+F+ V + +R + Sbjct: 179 LTFWSDVATSAPESGILGTTDPEEHENLRRQ----------TLFECVDYFMRLWNERVNA 228 Query: 296 QPGADFLCDIYQQD---HLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRL 352 P D + + + ++ + E + L + +TT N++ + L +NP R+L Sbjct: 229 PPKPDLISMLAHGESTKNMDRMEYLGNLILLIVGGNDTTRNTISGSVLALHQNPDQDRKL 288 Query: 353 LQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKG 412 + N + A + E++R + + R + LG + +G Sbjct: 289 RE------------------NPGLIPAMVSETIRWQTPLAYMRRRAKRDFELGGKTIREG 330 Query: 413 TVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQL 472 + + E+ + + + ER HL FG G C+G RLAELQL Sbjct: 331 DKVAMWYVSGNRDEEVIDRPNDYWIER-------PRVRQHLSFGFGVHRCVGNRLAELQL 383 Query: 473 HLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRPR 514 + I+ ++ + P ++ + ELP+ R Sbjct: 384 KIIWEEILARFPRLEVVGPP-RRVYSSFVKGYEELPVVIPTR 424 >3MGX-A nrPDB Length = 415 Score = 198 bits (502), Expect = 7e-51, Method: Composition-based stats. Identities = 67/408 (16%), Positives = 135/408 (33%), Gaps = 60/408 (14%) Query: 108 HLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLM 167 + L + + + + + +++ E ++ +++R L Sbjct: 67 VFSHRACAAVLAPSAPLTSEYGMMIGFDRDHPDNSGGRMMVVSEHEQHRKLRKLVGPLLS 126 Query: 168 KPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELN-KWSFESICLVLYEKRFGL 226 + KL +++ + D L R+ + G + D + + + +C +L Sbjct: 127 R-AAARKLAERVRIEVGDVLGRVLD-----GEVCDAATAIGPRIPAAVVCEIL------- 173 Query: 227 LQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCI 286 E+E ++ EL + + QAHT Sbjct: 174 -GVPAEDE--------DMLIDLTNHAFGGEDELFDGMTPR--QAHTEIL--------VYF 214 Query: 287 DNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNP 346 D + ++PG D + + D L+ ++ + + ETT +++ ++ L+ P Sbjct: 215 DELITARRKEPGDDLVSTLVTDDDLTIDDVLLNCDNVLIGGNETTRHAITGAVHALATVP 274 Query: 347 QAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGE 406 L V ++E +R T R + Sbjct: 275 GLLTALRDGSADV------------------DTVVEEVLRWTSPAMHVLRVTTADVTING 316 Query: 407 YALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRR 466 LP GT + F+D F P R P H+ FG G C+G Sbjct: 317 RDLPSGTPVVAWLPAANRDPAEFDDPDTFLPGR--------KPNRHITFGHGMHHCLGSA 368 Query: 467 LAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRPR 514 LA ++L + L + ++ V + EP + + ++ RELP+ F R Sbjct: 369 LARIELSVVLRVLAERVSRVDLEREPAWLRAI-VVQGYRELPVRFTGR 415 >5L94-A nrPDB Length = 410 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 71/411 (17%), Positives = 135/411 (32%), Gaps = 66/411 (16%) Query: 108 HLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILE--GQEWQRVRSAFQKK 165 + E L + R + + R A G ++ + +R+ K Sbjct: 49 VFHYDGVKEVLEQKNIFSSDRRPPQ------NQRQTALGTSLINIDPPKHAEMRALVNKA 102 Query: 166 LMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELN-KWSFESICLVLYEKRF 224 P + + KI + + L+ ++ L D D+ L+ I +L Sbjct: 103 FT-PKAMKAWEPKIARITNELLQEVEHLED-----IDIVEHLSYPLPVMVIADILG---- 152 Query: 225 GLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKP 284 I + ++ P + K+ Q A D + Sbjct: 153 ------------VPIEDQRQFKDWSDIIVAGPSNNERETLEKLQQEKMKANDELETYFYR 200 Query: 285 CIDNRLQRYSQQPGADFLCDIYQQDH----LSKKELYAAVTELQLAAVETTANSLMWILY 340 I+ + R PG D + + Q L+ +E+ L +A ETT N + +Y Sbjct: 201 IIEEKRTR----PGDDIISVLLQAKEEGKQLTDEEIVGFSILLLIAGNETTTNLISNTIY 256 Query: 341 NLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDK 400 L + + RL +E + L + ++E +R V R + + Sbjct: 257 CLMEDKASFERLKREKE------------------LLPSGIEEVLRYRSPVQALHRIVKE 298 Query: 401 PTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKR 460 L L G + + FED F+ +R P H+ FG G Sbjct: 299 DVTLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDR--------KPNVHMAFGRGIH 350 Query: 461 MCIGRRLAELQLHLALCWIIQKYDIVA-TDNEPVEMLHLGILVPSRELPIA 510 C+G LA ++ + L +I +Y + + + ++ + + +EL I Sbjct: 351 FCLGAPLARIEAKIMLAELIDRYPQMDWSPSFELKPIESTFVYGLKELLIR 401 >2VZM-A nrPDB Length = 436 Score = 195 bits (496), Expect = 4e-50, Method: Composition-based stats. Identities = 74/450 (16%), Positives = 140/450 (31%), Gaps = 78/450 (17%) Query: 76 KGGLKKQHDTLAEYHKKYGQIFRMK--LGSFDSVHLGSPSLLEALYRTESAHPQRLEIKP 133 + + T A + G R++ G+ + +G L + Sbjct: 42 QDFAADPYPTYARLRAE-GPAHRVRTPEGNEVWLVVGYDRARAVLAD--PRFSKDWRNST 98 Query: 134 WKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLD---KKINEVLADFLERM 190 + ++ + R+R + + + +++ ++ E++ ++ M Sbjct: 99 TPLTEAEAALNHNMLESDPPRHTRLRKL----VAREFTMRRVELLRPRVQEIVDGLVDAM 154 Query: 191 DELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFG 250 L GR + S I E L + + Sbjct: 155 --LAAPDGRADLMESLAWPLPITVI-----------------SELLGVPEPDRAAFRVWT 195 Query: 251 KMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQ--- 307 V P + + T + + + Q G D L + + Sbjct: 196 DAFVFPDDPAQA-------------QTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSD 242 Query: 308 --QDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQT 365 L+ +EL L +A ETT N + +Y L +P L + Sbjct: 243 EDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRAD---------- 292 Query: 366 PRAEDLRNMPYLKACLKESMRLTPSV-PFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGS 424 M L ++E +R V T R +P L +P G + + Sbjct: 293 --------MTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHR 344 Query: 425 SEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYD 484 + + F D H+F R + HL FG G CIG LA L+ +A+ ++++ Sbjct: 345 TPERFPDPHRFDIRR--------DTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCP 396 Query: 485 IVATDNEPVE--MLHLGILVPSRELPIAFR 512 +A D P E ++ + LPI +R Sbjct: 397 DLALDVSPGELVWYPNPMIRGLKALPIRWR 426 >3RWL-A nrPDB Length = 426 Score = 194 bits (494), Expect = 6e-50, Method: Composition-based stats. Identities = 48/297 (16%), Positives = 102/297 (34%), Gaps = 36/297 (12%) Query: 221 EKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDT--- 277 + F + + + E + + + + ++ +WD Sbjct: 156 GEEFDWVDRVSIEITTQMLATLFDFPFEERRKLTRWSDV---TTAAPGGGVVESWDQRKT 212 Query: 278 -IFKSVKPCIDNRLQRYSQQPGADFLCDIYQQ---DHLSKKELYAAVTELQLAAVETTAN 333 + + +R ++ PG D + + +++ +E V L + +TT N Sbjct: 213 ELLECAAYFQVLWNERVNKDPGNDLISMLAHSPATRNMTPEEYLGNVLLLIVGGNDTTRN 272 Query: 334 SLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF 393 S+ + L +NP +L N ++ + E +R + Sbjct: 273 SMTGGVLALHKNPDQFAKLKA------------------NPALVETMVPEIIRWQTPLAH 314 Query: 394 TTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHL 453 RT + LG + KG + + ++ + +F +R P HL Sbjct: 315 MRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDR-------PRPRQHL 367 Query: 454 PFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIA 510 FG G C+G RLAE+QL + I+ ++ + EP E + + ++ + Sbjct: 368 SFGFGIHRCVGNRLAEMQLRILWEEILTRFSRIEVMAEP-ERVRSNFVRGYAKMMVR 423 >5OFQ-A nrPDB Length = 409 Score = 191 bits (486), Expect = 5e-49, Method: Composition-based stats. Identities = 60/387 (15%), Positives = 129/387 (33%), Gaps = 53/387 (13%) Query: 127 QRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADF 186 + + K + R E+ +++++ + ++R+ K P I L+ I E+ Sbjct: 65 KNPSLFSSKRAMEERQES--ILMMDPPKHTKLRNLVNKAFT-PRAIQHLEGHIEEIADYL 121 Query: 187 LERMDELCDERGRIPDLYSEL-NKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTM 245 L+ + D+ + I E L + + Sbjct: 122 LDEVSSKEK-----FDIVEDFAGPLPIIVIA-----------------ELLGVPIQDRAL 159 Query: 246 MSTFGKMMVTPVELHKRL-NTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCD 304 + +V+ E + K+ Q + K I R Q + + L Sbjct: 160 FKKYSDDLVSGAENNSDEAFAKMMQKRNEGVIFLQGYFKEIIAERQQNKQEDLISLLLEA 219 Query: 305 IYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQ 364 +HL+++E+ L +A ETT N + + ++ + Q + +++ Sbjct: 220 EIDGEHLTEEEVLGFCILLLVAGNETTTNLITNGVRYMTEDVDVQNEVRRDIS------- 272 Query: 365 TPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGS 424 + ++E++R P + R + LGE + +G + Sbjct: 273 -----------LVPNLVEETLRYYPPIQAIGRIAAEDVELGECKIKRGQQVISWAASANR 321 Query: 425 SEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYD 484 FE F R H+ FG G C+G LA ++ +A +++K Sbjct: 322 DSAKFEWPDTFVVHR--------KTNPHVSFGFGIHFCLGAPLARMEGKIAFTKLLEKGG 373 Query: 485 IVATDNEPVEMLHLGILVPSRELPIAF 511 N+ ++ + + ++ IAF Sbjct: 374 FSKVQNQSLKPIDSPFVFGVKKYEIAF 400 >2Y5N-A nrPDB Length = 417 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 72/437 (16%), Positives = 140/437 (32%), Gaps = 78/437 (17%) Query: 92 KYG------QIFRMK--LGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNE 143 +YG + R++ G + + L + + + + Sbjct: 42 RYGELQETEPVSRVRPPYGEEAWLVTRYEDVRAVL--GDGRFVRGPSMTRDEPRTRPEMV 99 Query: 144 AYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDL 203 GL+ ++ E R+R K L + E+ + +++M G+ DL Sbjct: 100 KGGLLSMDPPEHSRLRRLVVKAFTARRA-ESLRPRAREIAHELVDQM----AATGQPADL 154 Query: 204 YSELNK-WSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKR 262 + + IC +L F +ST Sbjct: 155 VAMFARQLPVRVICELLGVPSADH---------DRFTRWSGAFLST-------------- 191 Query: 263 LNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQ----QDHLSKKELYA 318 + + + + + R ++P D + + Q QD LS++EL Sbjct: 192 -----AEVTAEEMQEAAEQAYAYMGDLIDRRRKEPTDDLVSALVQARDQQDSLSEQELLD 246 Query: 319 AVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLK 378 L +A E+T + +Y L P+ +R+LL + + Sbjct: 247 LAIGLLVAGYESTTTQIADFVYLLMTRPELRRQLLDRPE------------------LIP 288 Query: 379 ACLKESMRLTPSVPFT--TRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFR 436 + ++E R P T R + L + G + +T + F D+ + Sbjct: 289 SAVEELTRWVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRID 348 Query: 437 PERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVAT--DNEPVE 494 +R P HL FG G C+G LA ++L +AL ++Q+ + + Sbjct: 349 VDR--------TPNQHLGFGHGVHHCLGAPLARVELQVALEVLLQRLPGIRLGIPETQLR 400 Query: 495 MLHLGILVPSRELPIAF 511 +L ELP+ + Sbjct: 401 WSEGMLLRGPLELPVVW 417 >1CPT-A nrPDB Length = 428 Score = 188 bits (477), Expect = 5e-48, Method: Composition-based stats. Identities = 61/357 (17%), Positives = 125/357 (35%), Gaps = 48/357 (13%) Query: 160 SAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVL 219 +P I KL++ I + ++R+ + E + D + + L Sbjct: 114 RGLTLNWFQPASIRKLEENIRRIAQASVQRLLDFDGECDFMTDCALY---YPLHVVMTAL 170 Query: 220 YEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIF 279 + ++ E L + + + P ++ + + T + Sbjct: 171 G------VPEDDEPLMLKLTQDFFGVHEPDEQAVAAP----RQSADEAARRFHETIATFY 220 Query: 280 KSVKPCIDNRLQRYSQQPGADFLCDI----YQQDHLSKKELYAAVTELQLAAVETTANSL 335 +R P D + + +++ K + A + A +TT++S Sbjct: 221 DYFNGFTVDR----RSCPKDDVMSLLANSKLDGNYIDDKYINAYYVAIATAGHDTTSSSS 276 Query: 336 MWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT 395 + LSRNP+ Q L + +++P + E++R T V Sbjct: 277 GGAIIGLSRNPE-QLALAKSDPALIPRL-----------------VDEAVRWTAPVKSFM 318 Query: 396 RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPF 455 RT T + + +G + L+ E+ F + +F R+ P HL F Sbjct: 319 RTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITRF--------PNRHLGF 370 Query: 456 GIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFR 512 G G MC+G+ LA+L++ + ++ K V P ++ + + +PI F Sbjct: 371 GWGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSGPP-RLVATNFVGGPKNVPIRFT 426 >4RM4-A nrPDB Length = 396 Score = 187 bits (475), Expect = 9e-48, Method: Composition-based stats. Identities = 60/371 (16%), Positives = 126/371 (33%), Gaps = 55/371 (14%) Query: 118 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDK 177 LY E+ + + ++ ++ + ++RS K P + + + Sbjct: 52 LYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFT-PRVMKQWEP 110 Query: 178 KINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALT 237 +I E+ + +++ DL + + I E L Sbjct: 111 RIQEITDELIQKFQGR-----SEFDLVHD-FSYPLPVI---------------VISELLG 149 Query: 238 FITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQP 297 +A + ++V+ K + + +A D + + ++ +P Sbjct: 150 VPSAHMEQFKAWSDLLVSTP---KDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKP 206 Query: 298 GADFLCDIYQQDH----LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLL 353 D + + + + LS +EL T L +A ETT N + +Y++ P L Sbjct: 207 EQDIISILVEAEETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELR 266 Query: 354 QEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGT 413 + + ++E++R P R + T +G + + +G Sbjct: 267 ------------------SHPELMPQAVEEALRFRAPAPVLRRIAKRDTEIGGHLIKEGD 308 Query: 414 VLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLH 473 ++ E F+ H F R +P H+ FG G C+G LA L+ + Sbjct: 309 MVLAFVASANRDEAKFDRPHMFDIRR--------HPNPHIAFGHGIHFCLGAPLARLEAN 360 Query: 474 LALCWIIQKYD 484 +AL +I + Sbjct: 361 IALTSLISAFP 371 >2WM5-A nrPDB Length = 435 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 67/398 (16%), Positives = 129/398 (32%), Gaps = 59/398 (14%) Query: 120 RTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKI 179 R I + +++L+ QR+RS + P + +++ + Sbjct: 90 RHPDIFSSYPNITINDQTPELAEYFGSMIVLDDPRHQRLRSIVSRAFT-PKVVARIEAAV 148 Query: 180 NEVLADFLERMDELCDERGRIPDLYSEL-NKWSFESICLVLYEKRFGLLQKETEEEALTF 238 + + M + + R DL SEL + IC ++ + Sbjct: 149 RDRAHRLVSSM--IANNPDRQADLVSELAGPLPLQIICDMM---------------GIPK 191 Query: 239 ITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPG 298 + T + +L + + + + + Sbjct: 192 ADHQRIFHWTNVILGFGDPDLATDFDE---------FMQVSADIGAYATALAEDRRVNHH 242 Query: 299 ADFLCDIYQQD----HLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQ 354 D + + + LS +E+ + L +A ETT N++ + LSR P+ + R Sbjct: 243 DDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALSRYPEQRDRWWS 302 Query: 355 EVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTV 414 + + P ++E +R V + RTL + L + G Sbjct: 303 DFDGLAP-----------------TAVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDK 345 Query: 415 LTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPF-GIGKRMCIGRRLAELQLH 473 ++L E F D F R NP HL F G G C+G LA ++ Sbjct: 346 VSLWYCSANRDESKFADPWTFDLAR--------NPNPHLGFGGGGAHFCLGANLARREIR 397 Query: 474 LALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAF 511 +A + ++ V EP +L + + LP+ + Sbjct: 398 VAFDELRRQMPDVVATEEPARLL-SQFIHGIKTLPVTW 434 >3EJB-B nrPDB Length = 404 Score = 185 bits (469), Expect = 5e-47, Method: Composition-based stats. Identities = 55/425 (12%), Positives = 129/425 (30%), Gaps = 65/425 (15%) Query: 96 IFRMKLGSF----DSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYG--LMI 149 + + GSF G L ++ R + + ++ Sbjct: 25 VHPIYKGSFLKYPGWYVTGYEETAAIL--KDARFKVRTPLPESSTKYQDLSHVQNQMMLF 82 Query: 150 LEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNK 209 + +R+R+ P I E + L+++ + ++ + Sbjct: 83 QNQPDHRRLRTLAS-GAFTPRTTESYQPYIIETVHHLLDQVQ----GKKKMEVISDFAFP 137 Query: 210 WSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQ 269 + I ++ + + + ++ ++ + + Sbjct: 138 LASFVIANIIG-----------------VPEEDREQLKEWAASLIQTIDFTR------SR 174 Query: 270 AHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQ---DHLSKKELYAAVTELQLA 326 + + +Q+ + P D + + + D L+++E + L +A Sbjct: 175 KALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKDKLTEEEAASTCILLAIA 234 Query: 327 AVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMR 386 ETT N + + L ++P+ +L + + ++E +R Sbjct: 235 GHETTVNLISNSVLCLLQHPEQLLKLRENPD------------------LIGTAVEECLR 276 Query: 387 LTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKK 446 T R + + + +G + L F + F R Sbjct: 277 YESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITR------- 329 Query: 447 INPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRE 506 +P HL FG G +C+G LA L+ +A+ ++Q+ + + L E Sbjct: 330 -SPNPHLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEE 388 Query: 507 LPIAF 511 LP+ F Sbjct: 389 LPVTF 393 >6A7J-A nrPDB Length = 411 Score = 184 bits (468), Expect = 6e-47, Method: Composition-based stats. Identities = 78/437 (17%), Positives = 153/437 (35%), Gaps = 78/437 (17%) Query: 94 GQIFRMKL-GSFDSVHLGSPSLLEALYRTESAHPQ--------RLEIKPWKAYRDHRNEA 144 G + ++L G + AL R EI N Sbjct: 26 GPLAEVELPGGVHVYAVTHHKEARALLTDSRVVKDINVWNAWQRGEIPADWPLIGLVNPG 85 Query: 145 YGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLY 204 ++ ++G + +R+R+ + L + KL I + LER+ L G DL Sbjct: 86 RSMLTVDGPDHRRLRTLVAQALTV-KRVEKLRAGIEALTNASLERLAAL--PAGEPVDLK 142 Query: 205 SEL-NKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRL 263 +E I ++ +E F + TP E ++ Sbjct: 143 AEFAYPLPMNVISELMGVDAAD--HPRLKELFEKFFSTQ------------TPPEEVPQM 188 Query: 264 NTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIY----QQDHLSKKELYAA 319 T+F + ++ PG D + DHL+ +E+ Sbjct: 189 M--------ADLGTLFTKI-------VEEKKANPGDDLTSALIAASEDGDHLTDEEILNT 233 Query: 320 VTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQ-EVQSVLPDNQTPRAEDLRNMPYLK 378 + + A ETT + ++ ++ L+ +P+ ++++L E+ + Sbjct: 234 LQLIIAAGHETTISLIVNVVEALAIHPEQRKKVLSGEIP-------------------WE 274 Query: 379 ACLKESMRL-TPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNF-EDSHKFR 436 ++E++R TP+ R + +G+ LPKG L ++ LG E+ + + F Sbjct: 275 GVIEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGPTAGDFD 334 Query: 437 PERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEML 496 R P H+ FG G +C G L+ L+ +AL + +++ + E+ Sbjct: 335 ATR--------TPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPAAELR 386 Query: 497 HLGILVP--SRELPIAF 511 + I+ +LP+ Sbjct: 387 NKPIVTQNDLHDLPVKL 403 >4Z5P-A nrPDB Length = 400 Score = 184 bits (467), Expect = 8e-47, Method: Composition-based stats. Identities = 75/455 (16%), Positives = 150/455 (32%), Gaps = 75/455 (16%) Query: 69 SLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKL--GSFDSVHLGSPSLLEALYRTESAHP 126 + + + H AE + + R++L G + + A ++ Sbjct: 9 HIYPFEGEVDGLEIHPKFAELRET-DPLARVRLPYGGEGWMVTRYDDVRAA--NSDPRFS 65 Query: 127 QRLEIKPWKAYRDHRNEAYGLMIL-EGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLAD 185 R +I ++ + E R+R K + + + E+ A Sbjct: 66 -RAQIGEDTPRTTPLARRSDTILSLDPPEHTRLRRLLSKAFTA-RRMGAMQSWLEELFAG 123 Query: 186 FLERMDELCDERGRIPDLYSEL-NKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKT 244 L+ ++ G D+ +L ++ IC +L E+ F + Sbjct: 124 LLDGVER----TGHPADIVRDLAQPFTIAVICRLLG---------VPYEDRGRFQHWSEV 170 Query: 245 MMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCD 304 +MST T + ++ D S++ + + + P D L Sbjct: 171 IMST----------------TAYSKEEAVSAD---ASIRAYLADLVSARRAAPHDDLLGV 211 Query: 305 IY----QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVL 360 + D L++ EL L +A ET+A+ L ++Y L + L ++ + Sbjct: 212 LVSARDDDDRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSLLREQPE--- 268 Query: 361 PDNQTPRAEDLRNMPYLKACLKESMRLTPSV--PFTTRTLDKPTVLGEYALPKGTVLTLN 418 L ++E +R P R + L + G + Sbjct: 269 ---------------LLPRAVEELLRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAA 313 Query: 419 TQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCW 478 F+D + R HL FG G C+G +LA ++L +A+ Sbjct: 314 AVNANRDPRAFDDPDRLDITR--------EKNPHLAFGHGAHYCLGAQLARMELRVAIGG 365 Query: 479 IIQKYD--IVATDNEPVEMLHLGILVPSRELPIAF 511 +++++ +A + VE G+ + LPIA+ Sbjct: 366 LLERFPGLRLAVPADQVEWKTGGLFRGPQRLPIAW 400 >1Z8P-A nrPDB Length = 404 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 50/240 (20%), Positives = 91/240 (37%), Gaps = 33/240 (13%) Query: 279 FKSVKPCIDNRLQRYSQQPGADFLCDIYQ-----QDHLSKKELYAAVTELQLAAVETTAN 333 + V I + ++R +PG D L + + LS EL + L LA E++ + Sbjct: 189 AREVVNFILDLVERRRTEPGDDLLSALIRVQDDDDGRLSADELTSIALVLLLAGFESSVS 248 Query: 334 SLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF 393 + Y L +P + ++ + L ++E +R Sbjct: 249 LIGIGTYLLLTHPDQLALVRRDPSA------------------LPNAVEEILRYIAPPET 290 Query: 394 TTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHL 453 TTR + +G A+P+ + + + F D H+F R + HL Sbjct: 291 TTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRFDVTR--------DTRGHL 342 Query: 454 PFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVAT--DNEPVEMLHLGILVPSRELPIAF 511 FG G C+GR LA+L+ +AL + ++ ++ D + V +L LP+ Sbjct: 343 SFGQGIHFCMGRPLAKLEGEVALRALFGRFPALSLGIDADDVVWRRSLLLRGIDHLPVRL 402 >2XKR-A nrPDB Length = 398 Score = 182 bits (462), Expect = 3e-46, Method: Composition-based stats. Identities = 54/263 (20%), Positives = 90/263 (34%), Gaps = 32/263 (12%) Query: 257 VELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIY----QQDHLS 312 +L L++ V Q F + + P D + + + LS Sbjct: 157 DDLVTFLSSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDLVSVLVSSEVDGERLS 216 Query: 313 KKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLR 372 EL + + ETT ++L L RN L ++ Sbjct: 217 DDELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDPS--------------- 261 Query: 373 NMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDS 432 L ++E +R T V R L T AL G + L + E F + Sbjct: 262 ---LLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEP 318 Query: 433 HKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVAT--DN 490 KF +R NP +HL FG G C+G +LA L+L L ++++ + D+ Sbjct: 319 EKFDVQR--------NPNSHLAFGFGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADD 370 Query: 491 EPVEMLHLGILVPSRELPIAFRP 513 + + + +P+ F P Sbjct: 371 SVLPLRPANFVSGLESMPVVFTP 393 >6HQW-A nrPDB Length = 445 Score = 181 bits (458), Expect = 9e-46, Method: Composition-based stats. Identities = 60/323 (18%), Positives = 120/323 (37%), Gaps = 30/323 (9%) Query: 196 ERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVT 255 ++ ++ +E+ + + + + + +RF + K + E + + +++ Sbjct: 149 TPAKMVEMEAEIRRRTASVLDSLPWGERFDWVDKVSIELTTGMLAILFGFPWADRRLLTF 208 Query: 256 PVELHKRLNTKVWQA-HTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQD---HL 311 + + + + + + + R P D + + + H+ Sbjct: 209 WSDWAGDVELTLARELADTRFGFLGEMAHYFQRLWGARMQAPPSGDLISMMIHSEAMNHM 268 Query: 312 SKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDL 371 S +E + L + +TT N++ I++ L + P QR LL+ S++P+ Sbjct: 269 SPQEFMGNLVLLIVGGNDTTRNTMSGIVHALDKFPD-QRELLERDASLIPN--------- 318 Query: 372 RNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFED 431 ++E +R + RT T L + G + L E FE+ Sbjct: 319 --------AVQECIRYVTPLAHMRRTATADTELFGNQIKAGEKVILWYISANRDETVFEN 370 Query: 432 SHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNE 491 K +R N HL FG G C+G RLAELQL + L + ++ V E Sbjct: 371 PDKLMVDR-------PNARRHLSFGHGIHRCVGARLAELQLRILLEEMHERRMRVRVAGE 423 Query: 492 PVEMLHLGILVPSRELPIAFRPR 514 VE + + R+L + R Sbjct: 424 -VERVRANFVHGFRKLEVELEKR 445 >3WVS-A nrPDB Length = 401 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 67/381 (17%), Positives = 132/381 (34%), Gaps = 67/381 (17%) Query: 138 RDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDER 197 R +A + ++ + R+R K I ++++ +V D R+ + + Sbjct: 81 RKFNAQAKSMFNMDAPDHTRLRRLISKA----FTIRRVEELRPKV-HDLAHRLIDDMLAK 135 Query: 198 GRIPDLYSELN-KWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTP 256 G DL ++ IC +L E+ F ++ST Sbjct: 136 GEPADLVADYALPIPTTVICELLG---------VPFEDREKFGRWTDAILSTS------- 179 Query: 257 VELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQ----QDHLS 312 LN + + + + I + QP D + + + QD L+ Sbjct: 180 -----TLNPEEGRVKRM-------ELVGYIGGIIAARRAQPADDLISGMIEARDVQDKLT 227 Query: 313 KKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLR 372 ++EL L +A ETTA+ + +Y L PQ +RLL + + Sbjct: 228 EQELLDHCIGLLIAGHETTASQIPSFVYALLDQPQHWKRLLDDPE--------------- 272 Query: 373 NMPYLKACLKESMRLTPSVPFT--TRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFE 430 + + ++E R P + R + +G + G + + FE Sbjct: 273 ---LIPSAVEELFRFVPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVALGAANRDGLRFE 329 Query: 431 DSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDN 490 D + + +R H+ FG G C+G LA L+L AL ++++ + Sbjct: 330 DPEEIKLDR--------PSNHHIGFGHGIHHCLGAPLARLELQEALRALLERLPTLKVAG 381 Query: 491 EPVEMLHLGILVPSRELPIAF 511 + ++ R +P+ + Sbjct: 382 DIAWKSE-MMVRGPRSMPVGW 401 >3R9C-A nrPDB Length = 418 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 45/215 (20%), Positives = 75/215 (34%), Gaps = 30/215 (13%) Query: 282 VKPCIDNRLQRYSQQPGADFLCDIY----QQDHLSKKELYAAVTELQLAAVETTANSLMW 337 ++ + + + PG D + + D L++ E+ A L +A ETT N + Sbjct: 208 LRDYLRALIDERRRTPGEDLMSGLVAVEESGDQLTEDEIIATCNLLLIAGHETTVNLIAN 267 Query: 338 ILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRT 397 + R P L + A ++E+MR P V +R Sbjct: 268 AALAMLRTPGQWAALAADGSRA------------------SAVIEETMRYDPPVQLVSRY 309 Query: 398 LDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGI 457 +G + +PKG + L +F P+R HL FG Sbjct: 310 AGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPDRAQI--------RHLGFGK 361 Query: 458 GKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEP 492 G C+G LA L+ +AL + ++ EP Sbjct: 362 GAHFCLGAPLARLEATVALPALAARFPEARLSGEP 396 >4UBS-A nrPDB Length = 393 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 62/425 (14%), Positives = 129/425 (30%), Gaps = 74/425 (17%) Query: 98 RMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDH----RNEAYGLMILEGQ 153 + G V G + L + + A + R L+ ++ Sbjct: 32 SLYDGRSVWVVTGHAAARALLSDQ--RLSSDRTLPRFPATTERFEAVRTRRVALLGVDDP 89 Query: 154 EWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELN-KWSF 212 E + R ++ P +K + + + ++ + + + +G +L S Sbjct: 90 EHRTQRR-----MLVPSFTLKRAAALRPRIQETVDGLLDAMEAQGPPAELVSAFALPLPS 144 Query: 213 ESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHT 272 IC +L E++ L I + Sbjct: 145 MVICALLGVPYADHDFFESQSRRLLRGPGIAEV--------------------------- 177 Query: 273 LAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQ----DHLSKKELYAAVTELQLAAV 328 + + + R ++PG L D+ Q+ + + EL + T L +A Sbjct: 178 ---QDARAQLDDYLYALIDRKRKEPGDGLLDDLIQEQLNRGTVDRAELVSLATLLLIAGH 234 Query: 329 ETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLT 388 ETTAN + + L R+P+ L E + A ++E +R Sbjct: 235 ETTANMISLGTFTLLRHPEQLAELRAE------------------PGLMPAAVEELLRFL 276 Query: 389 PSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKIN 448 R + + + + T V+ F + R + Sbjct: 277 SIADGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHR--------S 328 Query: 449 PFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVAT--DNEPVEMLHLGILVPSRE 506 H+ FG G C+G+ LA ++ +AL + ++ + + + + E Sbjct: 329 ARHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLAAPADEIPFKPGDTIQGMLE 388 Query: 507 LPIAF 511 LP+ + Sbjct: 389 LPVTW 393 >4YZR-A nrPDB Length = 405 Score = 178 bits (451), Expect = 5e-45, Method: Composition-based stats. Identities = 45/247 (18%), Positives = 92/247 (37%), Gaps = 33/247 (13%) Query: 272 TLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDH----LSKKELYAAVTELQLAA 327 + + K I + +P D + + + LS+KELY+ + L +A Sbjct: 183 RELTNQALREFKDYIAKLIHDRRIKPKDDLISKLVHAEENGSKLSEKELYSMLFLLVVAG 242 Query: 328 VETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRL 387 +ETT N L L ++ + +L Q+ + + ++E +R Sbjct: 243 LETTVNLLGSGTLALLQHKKECEKLKQQPE------------------MIATAVEELLRY 284 Query: 388 TPSVPFTT-RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKK 446 T V R + +++ +G ++ + + FE+ R Sbjct: 285 TSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILNINR------- 337 Query: 447 INPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEP--VEMLHLGILVPS 504 +P H+ FG G C+G LA L+ H+A +++++ + P ++ L Sbjct: 338 -SPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQWRKNVFLRGL 396 Query: 505 RELPIAF 511 LP++ Sbjct: 397 ESLPVSL 403 >6CVC-A nrPDB Length = 433 Score = 178 bits (451), Expect = 5e-45, Method: Composition-based stats. Identities = 66/404 (16%), Positives = 124/404 (30%), Gaps = 49/404 (12%) Query: 109 LGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMK 168 L + R I + +++L+ QR+RS + Sbjct: 76 LTKHDDIHFASRHPEIFHSSPNIVIHDQTPELAEYFGSMIVLDDPRHQRLRSIVSRAFT- 134 Query: 169 PVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQ 228 P + +++ + E + M E G+ + + IC ++ Sbjct: 135 PKVVARIEASVRERAHRLVAAMIE-NHPDGQADLVSELAGPLPLQIICDMM-------GI 186 Query: 229 KETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDN 288 E + E + T + + +L I D+ Sbjct: 187 PEEDHEQIFHWTNV--------ILGFGDPDLTTDF-----DEFLQVSMAIGGYATALADD 233 Query: 289 RLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQA 348 R + + + LS E+ L +A ETT N++ + LSR P Sbjct: 234 RRVNHHGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNAISHGMLALSRYPDE 293 Query: 349 QRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYA 408 + + + + ++E +R V + RTL + L Sbjct: 294 RAKWWSDFDGLAA-----------------TAVEEIVRWASPVVYMRRTLSQDVDLRGTK 336 Query: 409 LPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPF-GIGKRMCIGRRL 467 + G +TL E+ F D F R NP + F G G C+G L Sbjct: 337 MAAGDKVTLWYCSANRDEEKFADPWTFDVTR--------NPNPQVGFGGGGAHFCLGANL 388 Query: 468 AELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAF 511 A ++ + + ++ V EP +L + + LP+A+ Sbjct: 389 ARREIRVVFDELRRQMPDVVATEEPARLL-SQFIHGIKRLPVAW 431 >6A7I-A nrPDB Length = 411 Score = 177 bits (449), Expect = 1e-44, Method: Composition-based stats. Identities = 73/436 (16%), Positives = 147/436 (33%), Gaps = 76/436 (17%) Query: 94 GQIFRMKL-GSFDSVHLGSPSLLEALYRTESAHPQ--------RLEIKPWKAYRDHRNEA 144 G + ++L G + + AL R EI N Sbjct: 26 GPLAEVELPGGVHVYAVTRHAEARALLTDSRVVKDIDVWNAWRRGEIPMDWPLIGLANPG 85 Query: 145 YGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLY 204 ++ ++G + +R+R+ + L + +L I + LE++ L G DL Sbjct: 86 RSMLTVDGADHRRLRTLVAQALTV-KRVERLRAGIEALTNASLEKLAAL--PAGEPVDLK 142 Query: 205 SEL-NKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRL 263 +E I ++ +E F + TP E ++ Sbjct: 143 AEFAYPLPMNVISELMGVDAAD--HPRLKELFEKFFSTQ------------TPPEEVPQM 188 Query: 264 NTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIY----QQDHLSKKELYAA 319 + + PG D + DHL+ +E+ Sbjct: 189 M---------------ADLGALFTKIVDAKRTNPGDDLTSALIAASENGDHLTDEEIVNT 233 Query: 320 VTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKA 379 + + A ETT + ++ ++ L +P+ ++++L Sbjct: 234 LQLIIAAGHETTISLIVNVVEALQTHPEQRKKVLNGEIG------------------WDG 275 Query: 380 CLKESMRL-TPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNF-EDSHKFRP 437 ++E++R TP+ R + +G+ LPKG L ++ LG E+ + + +F Sbjct: 276 VIEETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGALGRDEEQYGPTAGEFDA 335 Query: 438 ERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLH 497 R P H+ FG G +C G L+ L+ +AL + +++ + ++ + Sbjct: 336 TR--------TPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPASDLRN 387 Query: 498 LGILVP--SRELPIAF 511 I+ ELP+ Sbjct: 388 KPIVTQNDLHELPVKL 403 >5LIE-A nrPDB Length = 414 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 65/369 (17%), Positives = 109/369 (29%), Gaps = 62/369 (16%) Query: 151 EGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKW 210 + R+R + P I +++ + L+ + E G D E+ Sbjct: 99 DDPRHTRIRRLVSSG-LTPRMIRRVEDDLRRRARGLLDGV-----EPGAPFDFVVEIAA- 151 Query: 211 SFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQA 270 E + + + + + V P + Sbjct: 152 -------------------ELPMQMICILLGVPETDRHWLFEAVEPGFDFRGSRRATMP- 191 Query: 271 HTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQD-------HLSKKELYAAVTEL 323 L + + + +P D L + LS ELY L Sbjct: 192 -RLNVEDAGSRLYTYALELIAGKRAEPADDMLSVVANATIDDPDAPALSDAELYLFFHLL 250 Query: 324 QLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKE 383 A ETT NS+ L L+ NP + L + + L ++E Sbjct: 251 FSAGAETTRNSIAGGLLALAENPDQLQTLRSDFE------------------LLPTAIEE 292 Query: 384 SMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQK 443 +R T P RT + LG + G + + F+ + +F R Sbjct: 293 IVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITR---- 348 Query: 444 EKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVP 503 P HL FG G C+G LA L+L + ++ ++ V EP E Sbjct: 349 ----KPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRV-VEPAEWTRSNRHTG 403 Query: 504 SRELPIAFR 512 R L + R Sbjct: 404 IRHLVVELR 412 >2WIO-A nrPDB Length = 431 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 74/422 (17%), Positives = 135/422 (31%), Gaps = 69/422 (16%) Query: 95 QIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMI-LEGQ 153 +++ + G H+ + ++ + R + + + G++ ++ Sbjct: 62 PVWQDRYG---VWHVFRHADVQTVLRDTATFSSDP-----TRVIEGASPTPGMIHEIDPP 113 Query: 154 EWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSEL-NKWSF 212 E + +R P I L+ +I +V L + G DL L Sbjct: 114 EHRALRKVVSSAFT-PRTISDLEPRIRDVTRSLL-------ADAGESFDLVDVLAFPLPV 165 Query: 213 ESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHT 272 + E L + + V++ T A Sbjct: 166 TIVA-----------------ELLGLPPMDHEQFGDWSGAL---VDIQMDDPTDPALAER 205 Query: 273 LAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQD----HLSKKELYAAVTELQLAAV 328 +A + + + R PG D + + + L +E T L LA Sbjct: 206 IA--DVLNPLTAYLKARCAERRADPGDDLISRLVLAEVDGRALDDEEAANFSTALLLAGH 263 Query: 329 ETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLT 388 TT L I+ L +P ++ + A ++E +R Sbjct: 264 ITTTVLLGNIVRTLDEHPAHWDAAAEDPGRI------------------PAIVEEVLRYR 305 Query: 389 PSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKIN 448 P P RT K T + +P ++ D +D +F P R K Sbjct: 306 PPFPQMQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSR------KSG 359 Query: 449 PFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHL-GILVPSREL 507 A L FG G C+G LA L+ +AL II ++ + D + + H I++ +R L Sbjct: 360 GAAQLSFGHGVHFCLGAPLARLENRVALEEIIARFGRLTVDRDDERLRHFEQIVLGTRHL 419 Query: 508 PI 509 P+ Sbjct: 420 PV 421 >4OQS-A nrPDB Length = 433 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 66/438 (15%), Positives = 130/438 (29%), Gaps = 82/438 (18%) Query: 92 KYGQI--FRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMI 149 K + R G + + + R E K G Sbjct: 32 KLPPVSPMRFPDGHIGWLVTSHAAARTVMID--PRFSNRPEHK--HPVFSVIPRPGGATK 87 Query: 150 LEGQEWQRV-----RSAFQKKLMKPVEIMKL---DKKINEVLADFLERMDELCDERGRIP 201 W + +++ L+ + ++ + +I ++ D L+ M + G Sbjct: 88 APAPGWFINMDAPEHTRYRRMLISQFTVRRIKELEPRIVQITEDHLDAMAK----AGPPV 143 Query: 202 DLYSELN-KWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELH 260 DL IC +L +E T + ++ Sbjct: 144 DLVQAFALPVPSLVICELLGVS---YADHAFFQEQTTIMASVD----------------- 183 Query: 261 KRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAV 320 K T A + + I + P D L + L+ +EL Sbjct: 184 -----KTQDEVTTALGKLTR----YIAELVATKRLSPKDDLLGSLITDTDLTDEELTNIA 234 Query: 321 TELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKAC 380 L +A ETTAN L + L ++P+ L Sbjct: 235 LLLLVAGHETTANMLGLGTFALLQHPEQIAALDS-----------------------PDA 271 Query: 381 LKESMRLTPSVPFTT--RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPE 438 ++E +R V T R + L + KG + + + F++ + + Sbjct: 272 VEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLD 331 Query: 439 RWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYD--IVATDNEPVEML 496 R ++ H FG G C+G++LA +++ + + ++ +A E +++ Sbjct: 332 R-------VDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKLR 384 Query: 497 HLGILVPSRELPIAFRPR 514 LP+A+ R Sbjct: 385 EKSAAYGVWALPVAWDAR 402 >3P3Z-A nrPDB Length = 416 Score = 174 bits (442), Expect = 7e-44, Method: Composition-based stats. Identities = 49/232 (21%), Positives = 88/232 (37%), Gaps = 30/232 (12%) Query: 284 PCIDNRLQRYSQQPGADFLCDIYQQDH---LSKKELYAAVTELQLAAVETTANSLMWILY 340 + +++ +PG D DI + H L EL V + +A ETT + L +Y Sbjct: 208 DYLVAAIEKRKVEPGDDLTSDIVRAFHDGVLDDYELRTLVATVLVAGYETTNHQLALAMY 267 Query: 341 NLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLD 399 + +++P ++ + + ++E +R +P++P T TR Sbjct: 268 DFAQHPDQWMKIKENPE------------------LAPQAVEEVLRWSPTLPVTATRVAA 309 Query: 400 KPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGK 459 + + +P GT + + V F D+ +F + FG G Sbjct: 310 EDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADADRFDIT-------VKREAPSIAFGGGP 362 Query: 460 RMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAF 511 C+G LA L+L A+ + + D E LG+ P LP+ F Sbjct: 363 HFCLGTALARLELTEAVAALATRLDPPQIAGEITWRHELGVAGPDA-LPLRF 413 >5XJN-A nrPDB Length = 455 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 72/445 (16%), Positives = 144/445 (32%), Gaps = 62/445 (13%) Query: 78 GLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESAHP---------QR 128 + E ++ +F ++G + ++ + +R Sbjct: 60 DMHNPFPAYKELRQEEPVMFDERIG---YWVVTKYDDIKTTFDDWETFSSENAQAPVRKR 116 Query: 129 LEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLE 188 GL E R+R+ QK P L+ I ++ D +E Sbjct: 117 GPQATQIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFT-PRRYKALEPDIRAMVIDRVE 175 Query: 189 RMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMST 248 +M L +++ + D+ S+L + +I LT I A +M+ T Sbjct: 176 KM--LANDQ-HVGDMVSDL-AYDIPTIT------------------ILTLIGADISMVDT 213 Query: 249 F-GKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQ 307 + L+ + H ++ + + + AD + + Sbjct: 214 YKRWSDSRAAMTWGDLSDEEQIPHAHNLVEYWQECQRMVADAHAHGGDNLTADLVRAQQE 273 Query: 308 QDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPR 367 ++ E+ + + L A ETT + L +P+ + +L+ Sbjct: 274 GQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILE------------- 320 Query: 368 AEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSED 427 N + A + E +R + S+ R K T +G A+ +G + L E Sbjct: 321 -----NPKLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEA 375 Query: 428 NFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIV- 486 FE+ +F R N HL FG G C+G LA+LQ + L + + + Sbjct: 376 RFENGEEFDISR-------ANAREHLSFGFGIHYCLGNMLAKLQAKICLEEVTRLVPSLH 428 Query: 487 ATDNEPVEMLHLGILVPSRELPIAF 511 ++ + +P+ + Sbjct: 429 LVADKAIGFRENLSFRVPTSVPVTW 453 >5GWE-A nrPDB Length = 405 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 72/445 (16%), Positives = 144/445 (32%), Gaps = 62/445 (13%) Query: 78 GLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESAHP---------QR 128 + E ++ +F ++G + ++ + +R Sbjct: 10 DMHNPFPAYKELRQEEPVMFDERIG---YWVVTKYDDIKTTFDDWETFSSENAQAPVRKR 66 Query: 129 LEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLE 188 GL E R+R+ QK P L+ I ++ D +E Sbjct: 67 GPQATQIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFT-PRRYKALEPDIRAMVIDRVE 125 Query: 189 RMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMST 248 +M L +++ + D+ S+L + +I LT I A +M+ T Sbjct: 126 KM--LANDQ-HVGDMVSDL-AYDIPTIT------------------ILTLIGADISMVDT 163 Query: 249 F-GKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQ 307 + L+ + H ++ + + + AD + + Sbjct: 164 YKRWSDSRAAMTWGDLSDEEQIPHAHNLVEYWQECQRMVADAHAHGGDNLTADLVRAQQE 223 Query: 308 QDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPR 367 ++ E+ + + L A ETT + L +P+ + +L+ Sbjct: 224 GQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILE------------- 270 Query: 368 AEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSED 427 N + A + E +R + S+ R K T +G A+ +G + L E Sbjct: 271 -----NPKLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEA 325 Query: 428 NFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIV- 486 FE+ +F R N HL FG G C+G LA+LQ + L + + + Sbjct: 326 RFENGEEFDISR-------ANAREHLSFGFGIHYCLGNMLAKLQAKICLEEVTRLVPSLH 378 Query: 487 ATDNEPVEMLHLGILVPSRELPIAF 511 ++ + +P+ + Sbjct: 379 LVADKAIGFRENLSFRVPTSVPVTW 403 >4OQR-A nrPDB Length = 457 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 65/435 (14%), Positives = 128/435 (29%), Gaps = 82/435 (18%) Query: 92 KYGQI--FRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMI 149 K + R G + + + R E K G Sbjct: 71 KLPPVSPMRFPDGHIGWLVTSHAAARTVMID--PRFSNRPEHK--HPVFSVIPRPGGATK 126 Query: 150 LEGQEWQRV-----RSAFQKKLMKPVEIMKL---DKKINEVLADFLERMDELCDERGRIP 201 W + +++ L+ + ++ + +I + D L+ M + G Sbjct: 127 APAPGWFTNMDAPEHTRYRRMLISQFTVRRIKELEPRIVRITEDHLDAMAK----AGPPV 182 Query: 202 DLYSELN-KWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELH 260 DL IC +L +E T + ++ Sbjct: 183 DLVQAFALPVPSLVICELLGVS---YADHAFFQEQTTIMVSVD----------------- 222 Query: 261 KRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAV 320 K T A + + I + P D L + L+ +EL Sbjct: 223 -----KTQDEVTTALGKLTR----YIAELVATKRLSPKDDLLGSLITDTDLTDEELTNIA 273 Query: 321 TELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKAC 380 L +A ETTAN L + L ++P+ L Sbjct: 274 LILLVAGHETTANMLGLGTFALLQHPEQIANLDS-----------------------PDA 310 Query: 381 LKESMRLTPSVPFTT--RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPE 438 ++E +R V T R + L + KG + + + F++ + + Sbjct: 311 VEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLD 370 Query: 439 RWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYD--IVATDNEPVEML 496 R ++ H FG G C+G++LA +++ + + ++ +A E +++ Sbjct: 371 R-------VDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKLR 423 Query: 497 HLGILVPSRELPIAF 511 LP+A+ Sbjct: 424 EKSAAYGVWALPVAW 438 >6GMF-A nrPDB Length = 397 Score = 172 bits (435), Expect = 4e-43, Method: Composition-based stats. Identities = 55/415 (13%), Positives = 132/415 (31%), Gaps = 52/415 (12%) Query: 100 KLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPW-KAYRDHRNEAYGLMILEGQEWQRV 158 +L + +G + + R + + + ++ ++ ++ Sbjct: 31 RLQPQGFMAVGRYQDVARVLHDAKGFSNRGWAASLPRGVKWDTSMPPSIVQVDPPRHGKL 90 Query: 159 RSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLV 218 R+ K P + +L+ +I ++ + ++ + RG+ E + ++ Sbjct: 91 RTLVTKAFT-PRTVAQLEPRIRDIAHELVDGL------RGKS---TFEATVEVTVPMPMI 140 Query: 219 LYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTI 278 + + G+ E F M+ + + V +R + Sbjct: 141 VIAEMLGV----APERRADFKRWSDDMVGSLALVRVGNAAQLER-----------STQEF 185 Query: 279 FKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWI 338 + ++ R + + + L + L+ E+ + L +A ETT + + Sbjct: 186 YAYFSEVLEERRREPREDLISQLLAAEVDGEKLTAGEVLSFANTLLIAGNETTTSLIGNA 245 Query: 339 LYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTL 398 L L+ +P+ + + + A ++E +R R Sbjct: 246 LVALTDHPEQLAAAQAD------------------LSLVPAVVEEVLRYESPAQCIFRQT 287 Query: 399 DKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIG 458 +G+ +P +V+ E F D +F R + HL FG+ Sbjct: 288 MTDVEIGDERIPARSVVLPLLASANRDESRFPDPDRFDIHR--------DTKGHLAFGLD 339 Query: 459 KRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRP 513 CIG LA L+ + L ++ + + ++ V + LP+ Sbjct: 340 IHFCIGAPLARLEAKVMLEVLLARLGDIQRVSQEVSWSPSFFIRSPSTLPLRATV 394 >1GWI-A nrPDB Length = 411 Score = 171 bits (434), Expect = 5e-43, Method: Composition-based stats. Identities = 68/436 (15%), Positives = 150/436 (34%), Gaps = 77/436 (17%) Query: 94 GQIFRMKL-GSFDSVHLGSPSLLEALYRTESAHPQ--------RLEIKPWKAYRDHRNEA 144 G + ++L G + + +AL R EI N Sbjct: 30 GPLAAVELPGGVPVWAVTHHAEAKALLTDPRLVKDINVWGAWRRGEIPADWPLIGLANPG 89 Query: 145 YGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLY 204 ++ ++G E +R+R+ + L ++ + + + + +R+ + G + DL Sbjct: 90 RSMLTVDGAEHRRLRTLVAQALT-----VRRVEHMRGRITELTDRLLDELPADGGVVDLK 144 Query: 205 SEL-NKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRL 263 + + ++ G+ + + F K Sbjct: 145 AAFAYPLPMYVVADLM-----GIEEARLPRLKVLF---------------------EKFF 178 Query: 264 NTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQ----DHLSKKELYAA 319 +T+ +A + + + + PG D + Q DHL+ E+ + Sbjct: 179 STQTPPEEVVAT---LTELASIMTDTVAAKRAAPGDDLTSALIQASENGDHLTDAEIVST 235 Query: 320 VTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKA 379 + + A ETT + ++ + NLS +P+ + + L A Sbjct: 236 LQLMVAAGHETTISLIVNAVVNLSTHPEQRALV------------------LSGEAEWSA 277 Query: 380 CLKESMRL-TPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNF-EDSHKFRP 437 ++E++R TP+ R + +G+ +P G L ++ LG E + +F Sbjct: 278 VVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADRFDL 337 Query: 438 ERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLH 497 R + H+ FG G +C G L+ ++ +AL + ++ + E+ + Sbjct: 338 TR-------TSGNRHISFGHGPHVCPGAALSRMEAGVALPALYARFPHLDLAVPAAELRN 390 Query: 498 LGILVPSR--ELPIAF 511 ++ + ELP+ Sbjct: 391 KPVVTQNDLFELPVRL 406 >5FYF-A nrPDB Length = 470 Score = 171 bits (433), Expect = 6e-43, Method: Composition-based stats. Identities = 47/257 (18%), Positives = 90/257 (35%), Gaps = 38/257 (14%) Query: 268 WQAHTLAWDTIFKSVKPCIDNRLQR-----YSQQPGADFLCDIYQQDHLSKK------EL 316 + +D + + ++PG D + + Q + +K E Sbjct: 239 FADENAMFDDAADMARSFSRLWRDKEARRAAGEEPGFDLIS-LLQSNKETKDLINRPMEF 297 Query: 317 YAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPY 376 +T L + +TT NS+ L ++ P+ +L Sbjct: 298 IGNLTLLIVGGNDTTRNSMSGGLVAMNEFPREFEKLKA------------------KPEL 339 Query: 377 LKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFR 436 + + E +R + + R + LG + KG + + E F++ +F Sbjct: 340 IPNMVSEIIRWQTPLAYMRRIAKQDVELGGQTIKKGDRVVMWYASGNRDERKFDNPDQFI 399 Query: 437 PERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEML 496 +R + H+ FG G C+G RLAELQL + I++++D + EP E + Sbjct: 400 IDR-------KDARNHMSFGYGVHRCMGNRLAELQLRILWEEILKRFDNIEVVEEP-ERV 451 Query: 497 HLGILVPSRELPIAFRP 513 + L + P Sbjct: 452 QSNFVRGYSRLMVKLTP 468 >2Z36-A nrPDB Length = 413 Score = 171 bits (433), Expect = 7e-43, Method: Composition-based stats. Identities = 70/450 (15%), Positives = 137/450 (30%), Gaps = 63/450 (14%) Query: 71 LEIFWKGGLKKQHDTLAEYHKKYGQIFRMKL--GSFDSVHLGSPSLLEALYRTESAHPQR 128 LE+ + G E ++ I +++L G G L R Sbjct: 12 LELPVERGCPFAPPAAYERLRERAPINKVRLTSGGQAWWVSGHEEARAVLAD------GR 65 Query: 129 LEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLE 188 D R + + L L+ Q++RS ++ + + ++ Sbjct: 66 FS-------SDKRKDGFPLFTLDAATLQQLRSQ-PPLMLGMDGAEHSAARRPVIGEFTVK 117 Query: 189 RMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMST 248 R+ L P + ++ + + + + +AL+ + Sbjct: 118 RLAALR------PRIQDIVDHFIDDMLA--------TDQRPVDLVQALSLPVPSLVICEL 163 Query: 249 FGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIY-- 306 G R V + F ++ ID+ + R +PG D Sbjct: 164 LGVPYTDHDFFQSRTTMMVSRTSMEDRRRAFAELRAYIDDLITRKESEPGDDLFSRQIAR 223 Query: 307 --QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQ 364 Q+ L L + L A ETTAN + + L +P+ + Sbjct: 224 QRQEGTLDHAGLVSLAFLLLTAGHETTANMISLGVVGLLSHPEQLTVVKANPGR------ 277 Query: 365 TPRAEDLRNMPYLKACLKESMRLTPSVPF-TTRTLDKPTVLGEYALPKGTVLTLNTQVLG 423 ++E +R T+R + +G ++ G + ++ Sbjct: 278 ------------TPMAVEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSAN 325 Query: 424 SSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKY 483 F+D ER HL FG G C+G+ LA ++L + + ++ Sbjct: 326 WDPAVFKDPAVLDVER--------GARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRI 377 Query: 484 D--IVATDNEPVEMLHLGILVPSRELPIAF 511 +A E V ++ ELP+ + Sbjct: 378 PSLRLAVPMEDVPFKGDSVIYGVHELPVTW 407 >3SN5-A nrPDB Length = 491 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 81/500 (16%), Positives = 168/500 (33%), Gaps = 56/500 (11%) Query: 48 TDGETRNVTSLPGPTNW-PLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDS 106 T R P P LG L+ + L +K+G +F KL Sbjct: 5 TSSRRRQTGEPPLENGLIPYLGCALQFG-----ANPLEFLRANQRKHGHVFTCKLMGKYV 59 Query: 107 VHLGSPSLLEALYRTESAHP-QRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKK 165 + +P + ++ HR+ + ++G + + F K Sbjct: 60 HFITNPLSYHKVLCHGKYFDWKKFHFALSAKAFGHRS----IDPMDGNTTENINDTF-IK 114 Query: 166 LMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKW--SFESICLVLYEKR 223 ++ + L + + E L + + + FE+ L ++ + Sbjct: 115 TLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRD 174 Query: 224 FGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVK 283 + F + L L +++ A + + +S++ Sbjct: 175 LTRRDTQKAHILNNL--------DNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLR 226 Query: 284 PCIDNRLQRYSQQPGAD-FLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNL 342 + + S+ FL D E + A+ T + W L+ + Sbjct: 227 HENLQKRESISELISLRMFLNDTL--STFDDLEKAKTHLVVLWASQANTIPATFWSLFQM 284 Query: 343 SRNPQAQRRLLQEVQSVL----------PDNQTPRAEDLRNMPYLKACLKESMRLTPSVP 392 RNP+A + +EV+ L + +L ++P L + +KES+RL+ Sbjct: 285 IRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSS-AS 343 Query: 393 FTTRTLDKPTVL----GEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKIN 448 RT + L G Y + K ++ L Q++ + + D F+ +R+L + K Sbjct: 344 LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTK 403 Query: 449 ----------PFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNE------P 492 + ++PFG G +C GR A ++ L ++ +++ + + Sbjct: 404 TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLD 463 Query: 493 VEMLHLGILVPSRELPIAFR 512 LGIL P ++ ++ Sbjct: 464 QSRAGLGILPPLNDIEFKYK 483 >3NC3-A nrPDB Length = 441 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 75/450 (16%), Positives = 149/450 (33%), Gaps = 62/450 (13%) Query: 70 LLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRL 129 L + + ++ ++ + S DS + + + + HP Sbjct: 43 LFSVLSDQFQNNPYAYFSQLREE-DPVH--YEESIDSYFISRYHDVRYILQ----HPDIF 95 Query: 130 EIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLER 189 K + L + G+E R +++ I ++ ++ E Sbjct: 96 TTKSLVERAEPVMRGPVLAQMHGKEHSAKRRI----VVRSF-IGDALDHLSPLIKQNAEN 150 Query: 190 MDELCDERGRIPDLYSELNK--WSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMS 247 + ERG+ DL ++ K ++ ++ +KR E FIT+I Sbjct: 151 LLAPYLERGKS-DLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSGVADFITSISQSPE 209 Query: 248 TFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDI-- 305 +AH+L + + + ++ PG+D + + Sbjct: 210 A--------------------RAHSL---WCSEQLSQYLMPVIKERRVNPGSDLISILCT 246 Query: 306 --YQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDN 363 Y+ LS K++ A + + LAA E +L ++Y+L NP+ +L + Sbjct: 247 SEYEGMALSDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRS------ 300 Query: 364 QTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLG 423 + + E++R P V R L + TV+G + K T++ Sbjct: 301 ------------LVPRAIAETLRYKPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAAN 348 Query: 424 SSEDNFEDSHKFRPERWL--QKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQ 481 + FE F R K HL FG G C+G A+ ++ + ++ Sbjct: 349 RDPEAFEQPDVFNIHREDLGIKSAFSGAARHLAFGSGIHNCVGTAFAKNEIEIVANIVLD 408 Query: 482 KYDIVATDNEPVEMLHLGILVPSRELPIAF 511 K + + + L +AF Sbjct: 409 KMRNIRLEEDFCYAESGLYTRGPVSLLVAF 438 >3ABB-A nrPDB Length = 408 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 69/423 (16%), Positives = 134/423 (31%), Gaps = 70/423 (16%) Query: 98 RMKLGSFDSVHLGSPSLLEALYRTE-SAHPQRLEIKPW-KAYRDHRNEAYGLMILEGQEW 155 + G + G L S+ + + D A+ L+ ++ Sbjct: 43 TLFDGRPAWLITGHAEGRALLVDPRLSSDWGHPDFPVVVRRTEDRGGLAFPLIGVDDPVH 102 Query: 156 QRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELN-KWSFES 214 R R ++ P +K I L ++R+ + +G DL S + Sbjct: 103 ARQRR-----MLIPSFGVKRMNAIRPRLQSLVDRLLDDMLAKGPGADLVSAFALPVPSVA 157 Query: 215 ICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLA 274 IC +L +G E + V A + Sbjct: 158 ICELL-GVPYGDHD--------------------------FFEECSRNF---VGAATSAE 187 Query: 275 WDTIFKSVKPCIDNRLQRYSQQPGADFLCDIY----QQDHLSKKELYAAVTELQLAAVET 330 D F + + + R +P L ++ ++ L E+ L +A ET Sbjct: 188 ADAAFGELYTYLHGLVGRKQAEPEDGLLDELIARQLEEGDLDHDEVVMIALVLLVAGHET 247 Query: 331 TANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPS 390 T N++ L ++P+ LL++ +V ++E +R T Sbjct: 248 TVNAIALGALTLIQHPEQIDVLLRDPGAVSG------------------VVEELLRFTSV 289 Query: 391 VPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPF 450 R + +G + G + ++ ++ +E+ F R N Sbjct: 290 SDHIVRMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFDARR--------NAR 341 Query: 451 AHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYD--IVATDNEPVEMLHLGILVPSRELP 508 H+ FG G C+G+ LA +L +AL + + +A + V + ELP Sbjct: 342 HHVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLAVPLDEVPIKAGHDAQGPIELP 401 Query: 509 IAF 511 + + Sbjct: 402 VVW 404 >5VWS-A nrPDB Length = 393 Score = 167 bits (424), Expect = 7e-42, Method: Composition-based stats. Identities = 60/421 (14%), Positives = 135/421 (32%), Gaps = 66/421 (15%) Query: 95 QIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQE 154 ++R + G + + + L ++ R + P + G+ +++ E Sbjct: 32 PVWRDQFGIYH--VFRYDDVRQILGDYQTFSSDRTRLMP---TAQGFGKG-GITMIDPPE 85 Query: 155 WQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFES 214 + R P I ++ +I ++ L+ + P +L + Sbjct: 86 HRHQRRLITHAFT-PQSISAMEPRIRQIADHLLDEL----------PGPEFDLVEHFAYP 134 Query: 215 ICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLA 274 + +++ + G+ + F T +MS + P ++ + A Sbjct: 135 LPVIVIAELLGV----PPGDRHLFRTWSDRLMSLQVENYADP---------ELARTVAAA 181 Query: 275 WDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQD----HLSKKELYAAVTELQLAAVET 330 + + + P D L + Q + L +E+ + L LA T Sbjct: 182 M----TEMNDYLREHCRSRRTHPRDDLLTRLVQAEVEGKRLDLEEVVNTASLLLLAGHLT 237 Query: 331 TANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPS 390 T + + L +P+A++ + + + A L+ES+RL Sbjct: 238 TTVLIGNTMLCLWDHPEAEKAVRADPS------------------LIPAALEESLRLRSP 279 Query: 391 VPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPF 450 R + + +P + + F D +F R Sbjct: 280 FLQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFDLHR--------QTT 331 Query: 451 AHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVAT-DNEPVEMLHLGILVPSRELPI 509 H+ FG G C+G +L L+ +AL ++ ++ + E + I + +P+ Sbjct: 332 GHIAFGHGVHFCLGAQLGRLEGRIALERLLGRFTEIHPWPREGISFYQSAIF-GASRMPV 390 Query: 510 A 510 Sbjct: 391 R 391 >4GGV-A nrPDB Length = 418 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 57/391 (14%), Positives = 125/391 (31%), Gaps = 53/391 (13%) Query: 108 HLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLM 167 G P ++ L ++ + P D + ++ ++ R + Sbjct: 58 VYGYPEAMDILNDHDTFTSDLAHLLPVSV--DAPLLEGDMSQMDPPRHRKYRQLVSRAFT 115 Query: 168 KPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLL 227 P + ++ ++ ++ + L+ +D + DL L + V R L Sbjct: 116 -PRLVADMETRVADITRELLDAVDGKPEIEIAA-DLAYPLPVIVIAELLGVPAGDR-DLF 172 Query: 228 QKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCID 287 +K ++ F + + T G+ + +RL + + Sbjct: 173 KKWADDIIEGFSG--FSFLDTSGQGEQDVRDATERLRP----------------LLDYMA 214 Query: 288 NRLQRYSQQPGADFLCDIYQQD----HLSKKELYAAVTELQLAAVETTANSLMWILYNLS 343 + + P D L + Q + L+ E+ L + TT +L + L Sbjct: 215 GHVTERRRTPREDLLTHLVQAEVDGERLTDNEIVNVANILLVTGHITTTMTLGNTVLCLD 274 Query: 344 RNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTV 403 +P+ ++ + + ++E++R+ R + Sbjct: 275 ADPEVAAKVRADRS------------------LVPGAIEEALRVLSPSAALARGTSREVE 316 Query: 404 LGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCI 463 + +PK ++ L F D + P R +P H FG G C+ Sbjct: 317 VAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDPTR--------DPNPHFGFGRGIHFCL 368 Query: 464 GRRLAELQLHLALCWIIQKYDIVATDNEPVE 494 G LA L+ +AL + ++ ++ TD Sbjct: 369 GAPLARLEGRVALNALFDRFPVLRTDPAKPP 399 >5L1U-A nrPDB Length = 401 Score = 166 bits (419), Expect = 3e-41, Method: Composition-based stats. Identities = 77/435 (17%), Positives = 131/435 (30%), Gaps = 75/435 (17%) Query: 91 KKYGQIFRM-KLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMI 149 +K G I R+ G + + L A R L Sbjct: 28 QKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSN--PNPQPSAKSAARAFMVALAA 85 Query: 150 LEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSEL-N 208 + E + R A + L+ P + + + + ++ + + DL+ L Sbjct: 86 GDDHETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDELLDQLAASAPPVDLHRVLSF 145 Query: 209 KWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTK-- 266 + +C ++ P+ +R Sbjct: 146 RLPTMVVCD----------------------------------LLGVPLADRERFGQWAR 171 Query: 267 --VWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIY--QQDHLSKKELYAAVTE 322 Q+ F+ V + + R +PG D L ++ + LS ++ Sbjct: 172 GTFDQSDNEHSANTFQQVVDYMLELVARKRVEPGDDILSELIAEKDGALSDADIAHLGNA 231 Query: 323 LQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLK 382 + L ETT + L RNP QR L E + P A ++ Sbjct: 232 VLLFGYETTIVRIDLGTLLLLRNP-VQRAQLAEDPGLAP-----------------AAVE 273 Query: 383 ESMRLT----PSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPE 438 E +RL S R +GE + G + L + F D F Sbjct: 274 EILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGGLFDLT 333 Query: 439 RWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYD--IVATDNEPVEML 496 R + P +HL FG G R CIGR LA ++L + ++ +A E + Sbjct: 334 R-------VRPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPEESLRWQ 386 Query: 497 HLGILVPSRELPIAF 511 I E+P+ F Sbjct: 387 EHRITGGFDEIPVTF 401 >5DQN-A nrPDB Length = 426 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 49/227 (21%), Positives = 78/227 (34%), Gaps = 34/227 (14%) Query: 291 QRYSQQPGADFLCDIYQQD----HLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNP 346 + + P D + + + D LS E V L +A ETT NS+ + ++NP Sbjct: 212 EERAVNPTEDIVTKLIEADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFAQNP 271 Query: 347 QAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGE 406 +E D E +R V RT + LG Sbjct: 272 DQWELYKKERPETAAD--------------------EIVRWATPVSAFQRTALEDVELGG 311 Query: 407 YALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPF-GIGKRMCIGR 465 + KG + ++ + E+ FED H F R +P H+ F G G CIG Sbjct: 312 VQIKKGQRVVMSYRSANFDEEVFEDPHTFNILR--------SPNPHVGFGGTGAHYCIGA 363 Query: 466 RLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFR 512 LA + ++L I + P + G L + + + Sbjct: 364 NLARMTINLIFNAIADNMPDLKPIGAPERLK-SGWLNGIKHWQVDYT 409 >4WPZ-A nrPDB Length = 397 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 49/241 (20%), Positives = 82/241 (34%), Gaps = 36/241 (14%) Query: 281 SVKPCIDNRLQRYSQQPGADFLCDIYQ----QDHLSKKELYAAVTELQLAAVETTANSLM 336 S+ + + P D + ++ L+++E+ A + A ETTAN + Sbjct: 183 SLVNYFGELIAVKRENPADDLISELIAISDGDSTLTEREIIALSIGILSAGHETTANQIS 242 Query: 337 WILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPS---VPF 393 L L NP+ +L +++ + E +R P Sbjct: 243 MFLVTLLHNPEELDKLRDNREAI------------------PKAVDELLRFVPLTTTGGI 284 Query: 394 TTRTLDKPTVL-GEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAH 452 R L G LP G V+ + FED + R H Sbjct: 285 IPRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLNVTR--------ENNPH 336 Query: 453 LPFGIGKRMCIGRRLAELQLHLALCWIIQKYD--IVATDNEPVEMLHLGILVPSRELPIA 510 L FG G C+G +LA ++L AL I+ + +A + + I+ LPI Sbjct: 337 LAFGAGIHHCLGAQLARIELQEALGAILDRMPQVRLAVPESELRLKSASIIRGLESLPIT 396 Query: 511 F 511 + Sbjct: 397 W 397 >4JBT-A nrPDB Length = 410 Score = 164 bits (414), Expect = 1e-40, Method: Composition-based stats. Identities = 66/408 (16%), Positives = 134/408 (32%), Gaps = 75/408 (18%) Query: 94 GQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAY-------- 145 G + R+ L ++ + +L L W++ R Sbjct: 30 GPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDINAWSLWQSGTVTRQWPLIGMIDVDR 89 Query: 146 GLMILEGQEWQRVRSAFQKKLMK--PVEIMKLDKKINEVLADFLERMDELCDERGRIPDL 203 + ++G E +R+R + L + + ++ L D LER G + DL Sbjct: 90 SMFTVDGPEHRRLRIKTTQALTRRRLDALKPTIERYVAELLDDLER----AGADGAVVDL 145 Query: 204 YSEL-NKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKR 262 S I ++ E+ +T K S TP + R Sbjct: 146 KSVFAYPLPMRVISALMG---------VPSEDQEQLLTWYKAFFSIL-----TPQDERLR 191 Query: 263 LNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIY----QQDHLSKKELYA 318 + + ++R + +PG D + + L+++E+ Sbjct: 192 ---------------VIDEMHGYFTEMVRRKTAEPGDDLTSALIYATDGETPLTEEEVIG 236 Query: 319 AVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLK 378 + L A ETT + ++ + L +P+ R + + + Sbjct: 237 NLQALVAAGHETTVSLILTAVRALLSHPEQLRLVR---DGEIG---------------WE 278 Query: 379 ACLKESMRLT-PSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNF-EDSHKFR 436 ++E++R P + R + LG+ +P+G + ++ + +G D+ F Sbjct: 279 TAIEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVHGADADDFD 338 Query: 437 PERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYD 484 R H+ FG G +C G LA L+ +AL + ++ Sbjct: 339 ITR-------ATAARHISFGHGPHICPGAALARLEAAIALPALFTRFP 379 >4PWV-A nrPDB Length = 446 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 49/320 (15%), Positives = 100/320 (31%), Gaps = 32/320 (10%) Query: 199 RIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVE 258 L +++ + LV+ R G + + I ++ ++ Sbjct: 138 SPQALKPIVDQIRVNTTRLVVDAARRGECDFAADVAEQIPLNTISDLLGVPAADREFLLK 197 Query: 259 LHKRLNTKVWQAHTLAWDTIFKS-VKPCIDNRLQRYSQQPGADFLCDI----YQQDHLSK 313 L+K + + + ++ + + +P D + + L++ Sbjct: 198 LNKSALSSEDADQSATDAWLARNEILLYFSELVAERRAKPTEDVISVLANSMVDGKPLTE 257 Query: 314 KELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRN 373 + + L L ET+ S++ + ++ P L + Sbjct: 258 EVIVLNCYSLILGGDETSRLSMIDSVQTFTQYPDQWELLRDGKVT--------------- 302 Query: 374 MPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSH 433 L++ +E +R R L + G V+TL E+ F D + Sbjct: 303 ---LESATEEVLRWATPAMHFGRRAVTDMELHGQVIAAGDVVTLWNNSANRDEEVFADPY 359 Query: 434 KFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPV 493 F R +P H+ FG G C+G L ++H L + EP Sbjct: 360 AFDLNR--------SPNKHITFGYGPHFCLGAYLGRAEVHALLDALRTYTTGFEITGEP- 410 Query: 494 EMLHLGILVPSRELPIAFRP 513 + +H L LP+ +P Sbjct: 411 QRIHSNFLTGLSRLPVRIQP 430 >5XNT-A nrPDB Length = 411 Score = 162 bits (411), Expect = 3e-40, Method: Composition-based stats. Identities = 57/395 (14%), Positives = 120/395 (30%), Gaps = 61/395 (15%) Query: 98 RMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRN---EAYGLMILEGQE 154 G+ + L + R + + + E Sbjct: 36 SYHEGTDTWNVFKYEDVKRVLSDYKHFSSVRKRTTISVGTDSEEGSVPDKIKITEADPPE 95 Query: 155 WQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFES 214 ++ RS P + + +I E+ + +E MDE + D+ L Sbjct: 96 HRKRRSLLA-AAFTPRSLQNWEPRIQEIADELIEEMDEETE-----IDIVQSLASPLPII 149 Query: 215 ICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLA 274 + L + + + + ++ P + + + Sbjct: 150 VMSDLMGV----------------PSKDRLLFKKWVDILFLP------FDKEKQEEVNEL 187 Query: 275 WDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQD----HLSKKELYAAVTELQLAAVET 330 K + + + P D + D+ + + + E+ + A VET Sbjct: 188 KQVAAKEYYQYLYPIVVQKRLNPADDIISDLLKAEVDGEMFTDDEVVRTTMLILGAGVET 247 Query: 331 TANSLMWILYNLS-RNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTP 389 T++ L Y+L + + + L + + + ++E +R Sbjct: 248 TSHLLANSFYSLLYDDKEVYQELHENLD------------------LVPQAVEEMLRYRF 289 Query: 390 SVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINP 449 ++ RT+ + L L +G + + E+ FED+ R N Sbjct: 290 NLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMFEDAFTLNIHR-------PNN 342 Query: 450 FAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYD 484 HL FG G C+G LA L+ +AL ++K+ Sbjct: 343 KKHLTFGNGPHFCLGAPLARLEAKIALTTFLKKFK 377 >5Y1I-A nrPDB Length = 403 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 63/424 (14%), Positives = 119/424 (28%), Gaps = 67/424 (15%) Query: 98 RMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMIL--EGQEW 155 R+ GS V L +H + P + + E Sbjct: 37 RIWDGSTPWVVTRHADQRALLSDPRVSHDGLRDGYPHISADFKFLSMAQPSFAGQDDPEH 96 Query: 156 QRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELN-KWSFES 214 R+R + P +++ + E +D + + DL L Sbjct: 97 GRIRR----MVTLPFTARRIEAMRPAIQKITDELIDGMLAGP-KPVDLVEALALPVPVRV 151 Query: 215 ICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLA 274 IC +L E F+ M +++ Q +A Sbjct: 152 ICEMLG----------VPYEDREFLQQNNNAM------------IYRDTAQGDAQKAAIA 189 Query: 275 WDTIFKSVKPCIDNRLQRYSQQPGADFLCDI---YQQDHLSKKELYAAVTELQLAAVETT 331 + + G D L D+ + +++ + L A ETT Sbjct: 190 QAM-------YLKELVGTKLGDRGDDILSDLAVQVEAGEITQDDAAGIGMMLLGAGHETT 242 Query: 332 ANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSV 391 AN + L NP+ + D + + ++E +R Sbjct: 243 ANMIALGTLALLENPEQLAEVR----------------DSDDPKVIVNTVEELLRYLTIA 286 Query: 392 P-FTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFED-SHKFRPERWLQKEKKINP 449 R + +G + G + D + + + R N Sbjct: 287 QDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDIHR-------ANA 339 Query: 450 FAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDN--EPVEMLHLGILVPSREL 507 HL FG G C+G LA ++L + ++++ +A + + H I EL Sbjct: 340 RRHLAFGYGVHQCLGATLARVELQIVYSTLLRRIPTLALAGTLDEIPFKHDQIAHGVYEL 399 Query: 508 PIAF 511 P+ + Sbjct: 400 PVTW 403 >3TKT-A nrPDB Length = 450 Score = 162 bits (410), Expect = 4e-40, Method: Composition-based stats. Identities = 62/372 (16%), Positives = 122/372 (32%), Gaps = 51/372 (13%) Query: 146 GLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYS 205 L+ ++ + ++R Q M P + +LD +I ++ + ++RM G D + Sbjct: 123 SLVQMDAPKHPKLRRLTQDWFM-PKNLARLDGEIRKIANEAIDRML----GAGEEGDFMA 177 Query: 206 ELN-KWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLN 264 + + + +L E+ + + M + M L Sbjct: 178 LVAAPYPLHVVMQILG---------VPPEDEPKMLFLTQQMFGGQDEDMNK-----SGLK 223 Query: 265 TKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGAD----FLCDIYQQDHLSKKELYAAV 320 + + + + P D + + +S ++ Sbjct: 224 DLPPEQISQIVAGAVAEFERYFAGLAAERRRNPTDDVATVIANAVVDGEPMSDRDTAGYY 283 Query: 321 TELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKAC 380 A +TT+ S L+R+P R+ + L Sbjct: 284 IITASAGHDTTSASSAGAALALARDPDLFARVKADRN------------------LLPGI 325 Query: 381 LKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERW 440 ++E++R T V RT T L + G L LN F + KF P R Sbjct: 326 VEEAIRWTTPVQHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTR- 384 Query: 441 LQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGI 500 HL FG G C+G LA L++ + L ++ + D + EP + ++ Sbjct: 385 -------PANRHLAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEP-KRVNSTF 436 Query: 501 LVPSRELPIAFR 512 + + LP+ ++ Sbjct: 437 VGGFKSLPMRWK 448 >2ZBZ-A nrPDB Length = 412 Score = 162 bits (409), Expect = 4e-40, Method: Composition-based stats. Identities = 72/445 (16%), Positives = 133/445 (29%), Gaps = 83/445 (18%) Query: 84 DTLAEYHKKYGQIFRM--KLGSFDSVHLGSPSLLEAL-------YRTESAHPQRLEIKPW 134 D A+ G + R+ G V + + L RT+ P + Sbjct: 28 DGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPA--TSPAF 85 Query: 135 KAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELC 194 +A R+ GL E R I + ++ EV+ FL+ M Sbjct: 86 EAVRESPQAFIGLDPPEHGT----RRRMTISEFTVKRIKGMRPEVEEVVHGFLDEML--- 138 Query: 195 DERGRIPDLYSELN-KWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMM 253 G DL S+ IC ++ Sbjct: 139 -AAGPTADLVSQFALPVPSMVIC---------------------------RLLGVPYADH 170 Query: 254 VTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQ----D 309 + KRL V + T + +D + ++ +PGA + + Sbjct: 171 EFFQDASKRL---VQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGALVADQLANG 227 Query: 310 HLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAE 369 + ++EL + L +A ETTA+ + L +P+ L + Sbjct: 228 EIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRS------------ 275 Query: 370 DLRNMPYLKACLKESMRLTPSV-PFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDN 428 + ++E +R R + + G + + + Sbjct: 276 ------LVPGAVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTV 329 Query: 429 FEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYD--IV 486 +ED R + HL FG G C+G+ LA L+L + L ++ + + Sbjct: 330 YEDPDALDIHR--------SARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRL 381 Query: 487 ATDNEPVEMLHLGILVPSRELPIAF 511 A E + + + ELP+ + Sbjct: 382 AVPVEQLVLRPGTTIQGVNELPVTW 406 >3A50-A nrPDB Length = 411 Score = 162 bits (409), Expect = 4e-40, Method: Composition-based stats. Identities = 50/275 (18%), Positives = 96/275 (34%), Gaps = 38/275 (13%) Query: 252 MMVTPVELHKRLNTK----VWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIY- 306 ++ P E + V + + + + + L+R +P L + Sbjct: 153 LLGLPAEDRDDFSAWSSVLVDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLA 212 Query: 307 ----QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPD 362 D LS++EL A L +A ETT N + + L +P QR+LL E S++ Sbjct: 213 VSDMDGDRLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPD-QRKLLAEDPSLI-- 269 Query: 363 NQTPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDKPTVLGEYALPKGTVLTLNTQV 421 + ++E +R V R + +P G ++ L Sbjct: 270 ---------------SSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAA 314 Query: 422 LGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQ 481 D + + R + + FG G C+G +LA L+ +A+ + Sbjct: 315 ANRDADWMPEPDRLDITR--------DASGGVFFGHGIHFCLGAQLARLEGRVAIGRLFA 366 Query: 482 KYDIVATDNEPVEMLH--LGILVPSRELPIAFRPR 514 +A E+++ ++ +P+ PR Sbjct: 367 DRPELALAVGLDELVYRRSTLVRGLSRMPVTMGPR 401 >4MM0-A nrPDB Length = 399 Score = 161 bits (407), Expect = 7e-40, Method: Composition-based stats. Identities = 68/423 (16%), Positives = 142/423 (33%), Gaps = 72/423 (17%) Query: 98 RMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQR 157 M G + + L ++ R ++ + E+ +M + R Sbjct: 40 TMATGDPGFLVTRYEDVRFVL--SDPRFSVRQDLPGAPRLTEMTFES--VMTTDPPVHTR 95 Query: 158 VRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSEL-NKWSFESIC 216 +R + I ++ ++ E+ L+ M++ +G D+ L + IC Sbjct: 96 LRRLLSRDFTA-RRIERMRPRLEEIAEGLLDEMEK----KGAPADIVESLAVPFPITVIC 150 Query: 217 LVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWD 276 +L + F TM+S G M W Sbjct: 151 ELLG---------VPMVDVARFRGWADTMVSLTGYSM-------------------EDWT 182 Query: 277 TIFKSVKPCIDNRLQRYSQQPGADFLCDIY----QQDHLSKKELYAAVTELQLAAVETTA 332 +++ +D + + PG+D L + + + L+ ++ + L LA E + Sbjct: 183 AARDALESYLDGLVAAKRENPGSDLLSALVATAAEDNELTDHDVRSLSLILLLAGYEPAS 242 Query: 333 NSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVP 392 N L + L R P L ++ L + ++E MR P+ Sbjct: 243 NQLGSSVLTLLRFPDRLAELRRD------------------PGLLPSAVEELMRYAPAGD 284 Query: 393 F-TTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFA 451 R + +G+ +P + + +TQ F+D R +R Sbjct: 285 GALFRVTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTGLRLDR--------PDNQ 336 Query: 452 HLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEML---HLGILVPSRELP 508 H G G C+G LA ++L +A+ +++++ +A + + +L E+P Sbjct: 337 HTALGHGIHFCLGAALARVELQVAIGALLRRFPRLALATDESGLRWSSPGSMLSGFAEIP 396 Query: 509 IAF 511 + + Sbjct: 397 VTW 399 >6GK6-A nrPDB Length = 411 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 47/275 (17%), Positives = 93/275 (33%), Gaps = 41/275 (14%) Query: 252 MMVTPVELHKRLNTKVW--------QAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLC 303 ++ PVE R + + + + P D + Sbjct: 157 LLGLPVEDRGRFRRWTKILLAPAKDREFVERAQPVVEEFAAYFRALADARRKAPRDDLIS 216 Query: 304 DIY----QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSV 359 + Q+ LS EL + V L +A ETT + + + L +P +RRL E + Sbjct: 217 GLLLAEEQEHKLSPAELSSMVFLLLVAGHETTVHLIASGMLLLLSHPAERRRL-DEDPGL 275 Query: 360 LPDNQTPRAEDLRNMPYLKACLKESMR-LTPSVPFTTRTLDKPTVLGEYALPKGTVLTLN 418 + + ++E++R P+ T R + L +P G + Sbjct: 276 VG-----------------SAVEEALRCEGPAELSTIRWSLEDIELFGARVPAGEGVAAG 318 Query: 419 TQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCW 478 +F D +F R +P H+ FG G C+G LA ++ +A Sbjct: 319 LLAANRDPQHFPDPDRFDIGR--------SPNRHIGFGGGIHFCLGAMLARIEAAIAFST 370 Query: 479 IIQKYDIVATDNEPVEML--HLGILVPSRELPIAF 511 ++++ + +++ + +P+ F Sbjct: 371 LLRRLPRIELATSTRDIVWSEWPTIRGPAAVPVVF 405 >5H1Z-A nrPDB Length = 407 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 50/303 (16%), Positives = 103/303 (33%), Gaps = 30/303 (9%) Query: 211 SFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRL-NTKVWQ 269 + E + + + F + + E + + + + + + K + Sbjct: 126 TAEVLDSLEWNTPFDWVDTVSVELTTQMLAILFDFPWEERRKLTFWSDWAGDIELVKNEE 185 Query: 270 AHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQD---HLSKKELYAAVTELQLA 326 +++ + + + P D + + D + + E + L + Sbjct: 186 LRLERLRHMYECGGYFQNLWNAKIGKPPTPDLISMMIHSDAMAEMDQMEFLGNLILLIVG 245 Query: 327 AVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMR 386 +TT N++ + Y L P + +L + + ++E +R Sbjct: 246 GNDTTRNTMSAVAYGLDLFPDQRAKLEADPS------------------MIPNTVQEIIR 287 Query: 387 LTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKK 446 + RT + L + G L L E FE++ + +R Sbjct: 288 WQTPLAHMRRTATVDSELEGQQIKAGDKLALWYISANRDESVFENADRIIVDR------- 340 Query: 447 INPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRE 506 N HL FG G C+G RLAELQ+ + L + ++ V EP E + + R+ Sbjct: 341 PNARRHLAFGHGIHRCVGARLAELQIAVLLEEMAKRRMRVNVLGEP-ERVAACFVHGYRK 399 Query: 507 LPI 509 LP+ Sbjct: 400 LPV 402 >5XW2-A nrPDB Length = 419 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 60/413 (14%), Positives = 128/413 (30%), Gaps = 64/413 (15%) Query: 108 HLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLM 167 G +E L + + P A D L+ + + + +R Sbjct: 57 VYGYAEAIEVLGDPGTFSSHMSRLLPMGA--DEAFTEGDLLQTDPPDHRELRKLVSHAFT 114 Query: 168 KPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLL 227 P + +L+ +I + + L+ + + D + + ++ V+ Sbjct: 115 -PKVVAELEPRITALTQELLDAVADR--------DTFDLMTALAYPLPVTVV-------- 157 Query: 228 QKETEEEALTFITAIKTMMSTF-----GKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSV 282 E L+ +A + + + + +E ++++A + + + Sbjct: 158 -----AELLSIPSADRHLFEGWMTEIVHSLGDVSMEDAPEDQERIFEAGMAPMRKMLEYL 212 Query: 283 KPCIDNRLQRYSQQPGADFLCDIYQQD----HLSKKELYAAVTELQLAAVETTANSLMWI 338 + +R P D + + + + L+ + L +A TT + Sbjct: 213 REHAAECRRR----PRGDLMGKLIEAEVDGRRLTDNHIVNFAKMLLIAGYLTTTMLIGNT 268 Query: 339 LYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTL 398 + L P+ R+ + + L+ESMR V T R Sbjct: 269 VLCLDSYPEQAARVRADRS------------------LIPGLLEESMRFLSPVAATYRAT 310 Query: 399 DKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIG 458 + + L ++ + F + F R P HL FG G Sbjct: 311 TRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPELFDMTR--------GPNPHLGFGRG 362 Query: 459 KRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGI-LVPSRELPIA 510 C+G LA ++ +AL ++ ++ + TD E G LP+ Sbjct: 363 IHFCLGGPLARMEGRVALDHLLDRFPELYTDPERPPTFMPGFDTTGVSSLPLR 415 >1F4U-A nrPDB Length = 368 Score = 159 bits (402), Expect = 3e-39, Method: Composition-based stats. Identities = 69/397 (17%), Positives = 138/397 (34%), Gaps = 67/397 (16%) Query: 143 EAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPD 202 + +G WQ + K+++ D L + ER+++L + + R Sbjct: 9 RKKDPVYYDGNIWQVFSYRYTKEVLNNFSKFSSD------LTGYHERLEDLRNGKIRFDI 62 Query: 203 LY-------SELNKWSFESICLVLYEKR----------------FGLLQKETEEEALTFI 239 S+ ++ + + ++ Sbjct: 63 PTRYTMLTSDPPLHDELRSMSADIFSPQKLQTLETFIRETTRSLLDSIDPREDDIVKKLA 122 Query: 240 TAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWD--TIFKSVKPCIDNR-LQRYSQQ 296 + ++ K++ P+E ++ IF+ K ++ + Sbjct: 123 VPLPIIV--ISKILGLPIEDKEKFKEWSDLVAFRLGKPGEIFELGKKYLELIGYVKDHLN 180 Query: 297 PGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEV 356 G + + + + LS E + L +A ETT N + + + +R +R+ +E Sbjct: 181 SGTEVVSRVVNSN-LSDIEKLGYIILLLIAGNETTTNLISNSVIDFTRF-NLWQRIREEN 238 Query: 357 QSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLT 416 YLKA ++E++R +P V T R + LG+ + +G + Sbjct: 239 ------------------LYLKA-IEEALRYSPPVMRTVRKTKERVKLGDQTIEEGEYVR 279 Query: 417 LNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLAL 476 + E+ F D KF P+R NP HL FG G +C+G LA L+ +A+ Sbjct: 280 VWIASANRDEEVFHDGEKFIPDR--------NPNPHLSFGSGIHLCLGAPLARLEARIAI 331 Query: 477 CWIIQKY-DIVATDNEPVEMLHLGILVPSRELPIAFR 512 +++ I D E V +L + L + + Sbjct: 332 EEFSKRFRHIEILDTEKVPNE---VLNGYKRLVVRLK 365 >4YT3-A nrPDB Length = 410 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 52/333 (15%), Positives = 106/333 (31%), Gaps = 57/333 (17%) Query: 157 RVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESIC 216 R R + P + + +I E+ + + +MD G D+ + L + Sbjct: 97 RKRRSLLAAAFTPRSLQNWEPRIQEIADELIGQMD-----GGTEIDIVASLASPLPIIVM 151 Query: 217 LVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWD 276 L + + + + + P + + + Sbjct: 152 ADLMGV----------------PSKDRLLFKKWVDTLFLP------FDREKQEEVDKLKQ 189 Query: 277 TIFKSVKPCIDNRLQRYSQQPGADFLCDIY----QQDHLSKKELYAAVTELQLAAVETTA 332 K + + + P D + D+ + + E+ + A VETT+ Sbjct: 190 VAAKEYYQYLYPIVVQKRLNPADDIISDLLKSEVDGEMFTDDEVVRTTMLILGAGVETTS 249 Query: 333 NSLMWILYNLS-RNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSV 391 + L Y+L + + + L + + + ++E +R ++ Sbjct: 250 HLLANSFYSLLYDDKEVYQELHENLD------------------LVPQAVEEMLRFRFNL 291 Query: 392 PFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFA 451 RT+ + L L +G + + E+ FED R N Sbjct: 292 IKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHR-------PNNKK 344 Query: 452 HLPFGIGKRMCIGRRLAELQLHLALCWIIQKYD 484 HL FG G C+G LA L+ +AL ++K+ Sbjct: 345 HLTFGNGPHFCLGAPLARLEAKIALTAFLKKFK 377 >6HQD-A nrPDB Length = 420 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 41/295 (13%), Positives = 93/295 (31%), Gaps = 30/295 (10%) Query: 221 EKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTK-VWQAHTLAWDTIF 279 + F + + + E + + + + ++ + + + Sbjct: 150 GEEFNWVDRVSIELTTMMLATLLDFPFDDRRKLTRWSDIITTRPGYGLVDSWEQRESELM 209 Query: 280 KSVKPCIDNRLQRYSQQPGADFLCDIYQQ---DHLSKKELYAAVTELQLAAVETTANSLM 336 + + +R + P D + + L+ + + L + +TT +S+ Sbjct: 210 ECLAYFQRLYAERQAMPPKPDLISMLAHSPEMQDLTPTDFLGTLALLIVGGNDTTRSSMS 269 Query: 337 WILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTR 396 PQ ++ N L + + E +R + R Sbjct: 270 GSAMACHLYPQEFDKVR------------------NNRALLASVIPEVVRWQTPIAHMRR 311 Query: 397 TLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFG 456 T + + KG + + ++ + F +R HL FG Sbjct: 312 TALEDVEFRGKQIRKGDKVVMWYLSGNRDDEVIDRPMDFIADR-------PRARHHLSFG 364 Query: 457 IGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAF 511 G C+G RLAELQL + + ++Y + EPV + ++ ++P+ Sbjct: 365 FGIHRCLGNRLAELQLKILWEEMCERYSRIEVCGEPVR-VPSNLVHGYIDIPVRL 418 >6B11-A nrPDB Length = 440 Score = 159 bits (401), Expect = 4e-39, Method: Composition-based stats. Identities = 43/234 (18%), Positives = 78/234 (33%), Gaps = 28/234 (11%) Query: 280 KSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWIL 339 + I + R S + + LS ++ L A ETTA+ + + Sbjct: 233 DYLDRLISGKTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMSV 292 Query: 340 YNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLD 399 L ++P A R L N L + E +R R+ Sbjct: 293 LVLLQHPTAWREL------------------TVNPGLLPGAVDELLRYLSIADGLRRSAT 334 Query: 400 KPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGK 459 + + + G L E F + F R + H+ FG G Sbjct: 335 ADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHR--------SARRHVAFGYGP 386 Query: 460 RMCIGRRLAELQLHLALCWIIQKYDIVAT--DNEPVEMLHLGILVPSRELPIAF 511 C+G+ LA ++L +AL ++++ + D + + + ELP+A+ Sbjct: 387 HQCLGQNLARMELEVALGAVLERLPALRPTTDVAGLRLKSDSAVFGVYELPVAW 440 >3ABA-A nrPDB Length = 403 Score = 158 bits (399), Expect = 6e-39, Method: Composition-based stats. Identities = 67/422 (15%), Positives = 121/422 (28%), Gaps = 68/422 (16%) Query: 98 RMKLGSFDSVHLGSPSLLEALYRTESAHPQRLE-IKPWKAYRDHRNEAYGLMILEGQEWQ 156 G + G + AL R S Q + + L+ + E Sbjct: 38 TFTSGHEAWLVTGYEEVR-ALLRDSSFSVQVPHALHTQDGVVTQKPGRGSLLWQDEPEHT 96 Query: 157 RVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESIC 216 R K+ + L I ++ + L+ + + RG DL + Sbjct: 97 SDRKLLAKEFTV-RRMQALRPNIQRIVDEHLDAI----EARGGPVDLVKTFANAVPSMVI 151 Query: 217 LVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWD 276 L+ E F + MM A + Sbjct: 152 SDLFGV--------PVERRAEFQDIAEAMMRV--------------------DQDAAATE 183 Query: 277 TIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDH----LSKKELYAAVTELQLAAVETTA 332 + + +Q PG D + + + + L A L +AA +TTA Sbjct: 184 AAGMRLGGLLYQLVQERRANPGDDLISALITTEDPDGVVDDMFLMNAAGTLLIAAHDTTA 243 Query: 333 NSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVP 392 + L +P L ++ + ++E +R Sbjct: 244 CMIGLGTALLLDSPDQLALLREDPS------------------LVGNAVEELLRYLTIGQ 285 Query: 393 FT-TRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFA 451 F R + LG + KG + + E+ +F R P Sbjct: 286 FGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITR--------RPAP 337 Query: 452 HLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVAT--DNEPVEMLHLGILVPSRELPI 509 HL FG G CIG++LA ++L + + ++ + E + H + ELP+ Sbjct: 338 HLAFGFGAHQCIGQQLARIELQIVFETLFRRLPGLRLAKPVEELRFRHDMVFYGVHELPV 397 Query: 510 AF 511 + Sbjct: 398 TW 399 >5IT1-A nrPDB Length = 399 Score = 157 bits (398), Expect = 7e-39, Method: Composition-based stats. Identities = 62/423 (14%), Positives = 119/423 (28%), Gaps = 70/423 (16%) Query: 98 RMKLGSFDSVHLGSPSLLEALYRTESAHP-QRLE-IKPWKAYRDHRNEAYGLMILEGQEW 155 G + G + L + + + + L+ + E Sbjct: 38 TFTSGHEAWLVTGYEQVRAVL--RDPSFSVGVPHALHTQDGVVTQKPGRGSLLWQDAPEH 95 Query: 156 QRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESI 215 R K+ + L I ++ + L+ + + RG DL + Sbjct: 96 TDDRKLLAKEFTV-RRMQALRPNIQRIVDEHLDAI----EARGGPVDLVKTFANPVPSMV 150 Query: 216 CLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAW 275 L+ E F + MM A Sbjct: 151 ISDLFGV--------PAERRAEFQEIAEAMMRV--------------------DQDAAAT 182 Query: 276 DTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDH----LSKKELYAAVTELQLAAVETT 331 + + + +Q PG D + + + + L A L +AA +TT Sbjct: 183 EAAGMRLGGLLYQLVQERRANPGDDLISALITTEDPDGVIDDMFLMNAAGTLLIAAHDTT 242 Query: 332 ANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSV 391 A + L P L ++ + ++E +R Sbjct: 243 ACMIGLGTALLLDRPDQLALLQKDPS------------------LIGNAVEELLRYLTIG 284 Query: 392 PFTT-RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPF 450 F R + +G + KG + + ED +F R P Sbjct: 285 QFGAERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDITR--------RPA 336 Query: 451 AHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVAT--DNEPVEMLHLGILVPSRELP 508 HL FG G CIG++LA ++L + + +++ + E + + + ELP Sbjct: 337 PHLAFGFGAHQCIGQQLARIELQIVFGTLFRRFPTLRLAKPVEELRFRNDMVFYGVHELP 396 Query: 509 IAF 511 + + Sbjct: 397 VTW 399 >4XE3-A nrPDB Length = 407 Score = 157 bits (398), Expect = 9e-39, Method: Composition-based stats. Identities = 66/464 (14%), Positives = 141/464 (30%), Gaps = 75/464 (16%) Query: 60 GPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLG-SFDSVHLGSPSLLEAL 118 GPT + + H + + R++L + L + + Sbjct: 7 GPTPADAVPAYPFSLPHALDLDPHYAELRRDE---PVSRVRLPYGEGTAWLVTRMSDARI 63 Query: 119 YRTESAHPQRLEIKPWKA-YRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDK 177 +S P E G++ + + R+R K + + Sbjct: 64 VLGDSRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHTRLRRLVGKAFTA-----RRVE 118 Query: 178 KINEVLADFLERMDELCDERGRIPD-LYSELNKWSFESICLVLYEKRFGLLQKETEEEAL 236 ++ + ++ + + G D + + IC +L E+ Sbjct: 119 EMRPRVRSLVDSLLDDMVAHGSPADLVEFLAVPFPVAVICELLG---------VPLEDRD 169 Query: 237 TFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQ 296 F T M+S+ + + + +D + + Sbjct: 170 LFRTFSDAMLSST-------------------RLTAAEIQRVQQDFMVYMDGLVAQRRDA 210 Query: 297 PGADFLCDIY----QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRL 352 P D L + DHL+K E+ L +A ET+ N + +++ L Sbjct: 211 PTEDLLGALALATDNDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLT-------- 262 Query: 353 LQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFT--TRTLDKPTVLGEYALP 410 + + + + A ++E +R TP V R + L + Sbjct: 263 ----------ERKRYESLVADPALVPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVR 312 Query: 411 KGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAEL 470 G ++ E+ F+ + + R H+ FG G CIG +L L Sbjct: 313 AGEPCVVHFASANRDEEVFDHADELDFHR--------ERNPHIAFGHGAHHCIGAQLGRL 364 Query: 471 QLHLALCWIIQKYDIVATDNEPV---EMLHLGILVPSRELPIAF 511 +L AL +++++ + EPV + ++ +++ Sbjct: 365 ELQEALSALVRRFPTLDLA-EPVAGLKWKQGMLIRGLERQIVSW 407 >5FOI-A nrPDB Length = 408 Score = 157 bits (397), Expect = 1e-38, Method: Composition-based stats. Identities = 61/405 (15%), Positives = 124/405 (30%), Gaps = 70/405 (17%) Query: 98 RMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAY-GLMILEGQEWQ 156 ++ GS + + L +P + D + + +++L+ E Sbjct: 51 KVWDGSPTWLVSRYEHVRALLVD--PRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHT 108 Query: 157 RVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDL-YSELNKWSFESI 215 R+R F ++ + +I +++ L+R+ L D+ S + I Sbjct: 109 RLRRMF-ISAFSVRQVETMRPEIEKIVDGILDRLLALEP----PVDILTHLALPMSTQVI 163 Query: 216 CLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAW 275 C +L E F + S P + Sbjct: 164 CHLLG----------VPYEDREFFQERSELASRPNDDRSMPALI---------------- 197 Query: 276 DTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQ----DHLSKKELYAAVTELQLAAVETT 331 + +D ++ + P L + ++ +EL L A ET+ Sbjct: 198 -----ELVEYLDGLVRTKTAHPDTGLLGTAVTERLLKGEITHQELVNNAVLLLAAGHETS 252 Query: 332 ANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSV 391 AN + + L R+P+ L ++ + + + E +R Sbjct: 253 ANQVTLSVLTLLRHPETAAELREQPE------------------LMPNAVDELLRYHSIA 294 Query: 392 PFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFA 451 R VLG++ + G L + + F F R Sbjct: 295 DGLRRAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHR--------PARH 346 Query: 452 HLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEML 496 H+ FG G C+G+ LA L++ + L + ++ + EP + Sbjct: 347 HVAFGYGPHQCLGQNLARLEMEVTLGKLFRRVPALRLAQEPDALR 391 >3IVY-A nrPDB Length = 433 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 48/229 (20%), Positives = 77/229 (33%), Gaps = 34/229 (14%) Query: 291 QRYSQQPGADFLCDIYQQD----HLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNP 346 + ++ P D + + Q D LS E V L +A ETT NS+ + + +P Sbjct: 229 EEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFAEHP 288 Query: 347 QAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGE 406 + D E +R V RT + L Sbjct: 289 DQWELYKKVRPETAAD--------------------EIVRWATPVTAFQRTALRDYELSG 328 Query: 407 YALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPF-GIGKRMCIGR 465 + KG + + + E+ F+D F R NP H+ F G G CIG Sbjct: 329 VQIKKGQRVVMFYRSANFDEEVFQDPFTFNILR--------NPNPHVGFGGTGAHYCIGA 380 Query: 466 RLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRPR 514 LA + ++L + + + P E L G L + + + R Sbjct: 381 NLARMTINLIFNAVADHMPDLKPISAP-ERLRSGWLNGIKHWQVDYTGR 428 >1ODO-A nrPDB Length = 408 Score = 156 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 69/445 (15%), Positives = 134/445 (30%), Gaps = 76/445 (17%) Query: 83 HDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQ-RLEIKPWKAYRDHR 141 H T ++ G + + + + P LL+ L + R + Sbjct: 17 HHTEHRTLREGGPATWVDVLGVQAWSVSDPVLLKQLLTSSDVSKDARAHWPAFGEVVGTW 76 Query: 142 NEAYGLMILE-----GQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDE 196 A + + G +++R + + + ++ ++R+ EL Sbjct: 77 PLALWVAVENMFTAYGPNHRKLRRLVAPAFSA-RRVDAMRPAVEAMVTGLVDRLAEL--P 133 Query: 197 RGRIPDLYSEL-NKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVT 255 G DL EL I G L ++ F + + T Sbjct: 134 AGEPVDLRQELAYPLPIAVI---------GHLMGVPQDRRDGFRALVDGVFDTTLD---- 180 Query: 256 PVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIY-------QQ 308 +++ + I + PG D + Sbjct: 181 ------------QAEAQANTARLYEVLDQLIAAK----RATPGDDMTSLLIAARDDEGDG 224 Query: 309 DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRA 368 D LS +EL + + A ETT N + ++ L P + + Sbjct: 225 DRLSPEELRDTLLLMISAGYETTVNVIDQAVHTLLTRPDQLALVRK---------GEVTW 275 Query: 369 EDLRNMPYLKACLKESMRLTPSVPFTT-RTLDKPTVL-GEYALPKGTVLTLNTQVLGSSE 426 D ++E++R P+V R L + +G + + Sbjct: 276 AD---------VVEETLRHEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHP 326 Query: 427 DNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIV 486 D ED+ F R +++ HL FG G C+G LA +++ LAL + ++ + Sbjct: 327 DWHEDADTFDATRTVKE--------HLAFGHGVHFCLGAPLARMEVTLALESLFGRFPDL 378 Query: 487 AT--DNEPVEMLHLGILVPSRELPI 509 E + + I + LP+ Sbjct: 379 RLADPAEELPPVPSLISNGHQRLPV 403 >6F0B-A nrPDB Length = 395 Score = 154 bits (388), Expect = 1e-37, Method: Composition-based stats. Identities = 63/427 (14%), Positives = 137/427 (32%), Gaps = 77/427 (18%) Query: 98 RMKLGSFDSVHLGSPSLLEALYRTE-SAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQ 156 + G+ V G + L S+ +R + A + + + + Sbjct: 33 GLWNGTPAHVFSGYEDVRTVLQDRRFSSDSRRPNFTELTPTLQSQAAAPPFVRTDNPDHR 92 Query: 157 RVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESIC 216 R+R ++ + P I L I E++ L+ + E L ++ Sbjct: 93 RLRGTIAREFL-PKHIELLRPAIREIVQGVLDGLAETAP-------PQDMLEAFAVPVAS 144 Query: 217 LVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWD 276 ++ +++ P E L V + Sbjct: 145 ATVF------------------------------RLLGIPAEDRALLTRCVKGVVSAVGS 174 Query: 277 T-----IFKSVKPCIDNRLQRYSQQPGADFLCDI----YQQDHLSKKELYAAVTELQLAA 327 +F+++ I +Q S+ P + + YQ+ L+ E + L + Sbjct: 175 EDEGAEVFRTLGEYIGGLVQDPSELPEDSLIRRLVTGPYQEKQLTFHETIGVILMLIVGG 234 Query: 328 VETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRL 387 +TTA+++ L + + P+ + + + + P L ++E +R Sbjct: 235 YDTTASTISLSLVSYALQPEKFSVVHEHPERI---------------PLL---VEELLRY 276 Query: 388 TPSVPFTT-RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKK 446 R + +G + G ++ + E F + + +R Sbjct: 277 HTVSQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR------- 329 Query: 447 INPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYD--IVATDNEPVEMLHLGILVPS 504 H+ FG G C+G+ LA ++L A+ +I++ +A E + H Sbjct: 330 -PSVPHVGFGYGPHQCVGQALARVELQEAIPAVIRRLPGMRLACALEDLPFRHDMATYGI 388 Query: 505 RELPIAF 511 ELP+ + Sbjct: 389 HELPMTW 395 >3B98-A nrPDB Length = 475 Score = 154 bits (388), Expect = 1e-37, Method: Composition-based stats. Identities = 85/488 (17%), Positives = 170/488 (34%), Gaps = 56/488 (11%) Query: 52 TRNVTSLPGPTNW-PLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLG 110 TR P P LG LE K L +K+G IF ++ L Sbjct: 14 TRRRNEPPLDKGMIPWLGHALEFG-----KDAAKFLTRMKEKHGDIFTVRAAGLYITVLL 68 Query: 111 SPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPV 170 + +A+ + N ++ E ++ R+ + Sbjct: 69 DSNCYDAVL--SDVASLDQTSYAQVLMKRIFNM---ILPSHNPESEKKRAEMHFQ----- 118 Query: 171 EIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKE 230 +++ + + L + ++ + ++W + + + Y F Sbjct: 119 --GASLTQLSNSMQNNLRLLM-------TPSEMGLKTSEWKKDGLFNLCYSLLFKTGYLT 169 Query: 231 TEEEALTFITAIKTMMSTFGKMMVTPVELHKRL-NTKVWQAHTLAWDTIFKSVKPCIDNR 289 A+ + F + +L + N + Q + A + ++K + P +R Sbjct: 170 VFGAENNNSAALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASAAREKLWKWLTPSGLDR 229 Query: 290 LQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTAN-SLMWILYNLSRNPQA 348 R G+ ++ + QD E+ LQL + A + W++ L +P+A Sbjct: 230 KPREQSWLGS-YVKQL--QDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEA 286 Query: 349 QRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVL---- 404 R + +E+Q E +N P + L E++RLT TR + + + Sbjct: 287 LRAVREEIQ---GGKHLRLEERQKNTPVFDSVLWETLRLTA-AALITRDVTQDKKICLSN 342 Query: 405 -GEYALPKGTVLTLNTQVLGS-SEDNFEDSHKFRPERWLQKEKKINP----------FAH 452 EY L +G L + + + F+ +R+L ++ + Sbjct: 343 GQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVKYPS 402 Query: 453 LPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATD-NEPVEMLH-----LGILVPSRE 506 +P+G +C GR A + + I+ ++D+ D N V ++ GIL P+ + Sbjct: 403 VPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGD 462 Query: 507 LPIAFRPR 514 L I +R R Sbjct: 463 LEIRYRIR 470 >4Z5Q-A nrPDB Length = 423 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 39/239 (16%), Positives = 92/239 (38%), Gaps = 33/239 (13%) Query: 279 FKSVKPCIDNRLQRYSQQPGADFLCDIYQQ----DHLSKKELYAAVTELQLAAVETTANS 334 F ++ ++ ++ +P D + + D L++ EL + + ETTA+ Sbjct: 212 FMDLQKYFEDLVKERRAEPRDDLTSALIEARDAHDRLAEPELIGLCISILIGGFETTASE 271 Query: 335 LMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVP-- 392 + ++ L + + RL + +++ A ++E +R P Sbjct: 272 ISSFVHVLQQRRELWTRLCADPEAI------------------PAAVEELLRFVPFAANG 313 Query: 393 FTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAH 452 + R + +G + +G + ++T + F+++ + +R H Sbjct: 314 ISPRYALEDMTVGGVLVREGEPVIVDTSAVNRDGLVFDNADEVVIDRAD--------NRH 365 Query: 453 LPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAF 511 + FG G C+G LA ++L AL +++ + + VE I+ R + + + Sbjct: 366 MVFGHGAHHCLGAHLARVELQEALKALVEGMPGLRLSGD-VEWKADMIIRAPRVMHVEW 423 >5YSW-A nrPDB Length = 441 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 38/240 (15%), Positives = 81/240 (33%), Gaps = 34/240 (14%) Query: 279 FKSVKPCIDNRLQRYSQQPGADFLCDIYQQDH----LSKKELYAAVTELQLAAVETTANS 334 +++ + + P D + + L+ EL L +A +TTA+ Sbjct: 226 ADALRAFMQALVTDKRANPAGDIISGLIHHAGADPALTDDELINIANLLLIAGYDTTASM 285 Query: 335 LMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSV-PF 393 L ++ L + P L + + ++E +R V P Sbjct: 286 LGLGIFVLLQRPAQLATLRDDPSRIA------------------DAVEELLRYLSVVNPG 327 Query: 394 TTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHL 453 R + +P G+ + ++ ++ D + HL Sbjct: 328 IFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDPD---------LDLTRPRGPHL 378 Query: 454 PFGIGKRMCIGRRLAELQLHLALCWIIQKYD--IVATDNEPVEMLHLGILVPSRELPIAF 511 FG G C+G++LA +++ ++++ +A E V + + + LPIA+ Sbjct: 379 AFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVPPEEVPLRNDMLTYGVHSLPIAW 438 >5EX6-C nrPDB Length = 434 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 67/424 (15%), Positives = 129/424 (30%), Gaps = 74/424 (17%) Query: 94 GQIFRMKLGS-----FDSVHLGSPSLLEALYRTESAHPQRLEIKP-----WKAYRDHRNE 143 G++ R++LGS + G + + L + R K R Sbjct: 62 GELTRVRLGSGADAEHTWLATGHDVVRQVLGDH-TRFSTRRRFDRNDEIGGKGVFRPREL 120 Query: 144 AYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDL 203 LM + E R+R K+ + + ER+DE + G DL Sbjct: 121 VGNLMDYDPPEHTRLRRLLAP----GFTHRKIRRMAPYIEQIVTERLDE-MEREGSPADL 175 Query: 204 YSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRL 263 + E L + M H+ L Sbjct: 176 IELF----------------ADEVPGPVLCELLGVPRDDRAMFLQL---------CHRHL 210 Query: 264 NTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIY--QQDHLSKKELYAAVT 321 + + A ++ + + R + PG + + D ++ +EL Sbjct: 211 DASLSGRRRAAAG---EAFSRYLVTMVARERKDPGDGLIGMVVAEHGDTVTDEELRGVCV 267 Query: 322 ELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACL 381 ++ LA + + + + L RNP+ L +V P + + Sbjct: 268 QMMLAGDDNISGMIGLGVLALLRNPEQIAALRGDV------------------PAAERAV 309 Query: 382 KESMRL-TPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERW 440 E +R T T RT + + +G+ + G + + D+ + R Sbjct: 310 DELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADRLDVTR- 368 Query: 441 LQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGI 500 H+ FG G C+G LA L+L +A + +++ + +P + Sbjct: 369 -------EAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLA-DPDGATEFRL 420 Query: 501 LVPS 504 P+ Sbjct: 421 STPA 424 >2RFC-A nrPDB Length = 343 Score = 152 bits (385), Expect = 3e-37, Method: Composition-based stats. Identities = 46/275 (16%), Positives = 95/275 (34%), Gaps = 35/275 (12%) Query: 241 AIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGAD 300 A++ ++ K++ P D F V + +RL + Sbjct: 99 AVRLPVNIISKILGIPDSDMPLFKLWSDYIIGNKRDENFNYVNNRMVSRLLEIFKSDSHG 158 Query: 301 FLCDI----YQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEV 356 + + + L+ E + L + ETT N + ++ + NP + Sbjct: 159 IINVLAGSSLKNRKLTMDEKIKYIMLLIIGGNETTTNLIGNMIRVIDENPDI-------I 211 Query: 357 QSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTLDKPTVLGEYALPKGTVL 415 L + ++E++R + F R + + + + KG + Sbjct: 212 DDALKNRS--------------GFVEETLRYYSPIQFLPHRFAAEDSYINNKKIKKGDQV 257 Query: 416 TLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLA 475 + E F++ F+ R HL FGIG MC+G LA L+ +A Sbjct: 258 IVYLGSANRDETFFDEPDLFKIGRREM---------HLAFGIGIHMCLGAPLARLEASIA 308 Query: 476 LCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIA 510 L I+ + + D + +L +++ +L ++ Sbjct: 309 LNDILNHFKRIKIDYKKSRLLDNKMVLGYDKLFLS 343 >6DCD-A nrPDB Length = 424 Score = 151 bits (382), Expect = 5e-37, Method: Composition-based stats. Identities = 58/257 (22%), Positives = 94/257 (36%), Gaps = 38/257 (14%) Query: 270 AHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQ---DHLSKK--ELYAAVTELQ 324 H + + ++ +QP D L + D + + ++ + T L Sbjct: 191 DHESVGVNPLQWLDDKFSAYIEDRRRQPRNDVLTALATATYPDGSTPEVIDVVRSATFLF 250 Query: 325 LAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKES 384 A ETTA L + L P QRRL + N + ++ES Sbjct: 251 AAGQETTAKLLTAAMRVLGDRPDIQRRLRE------------------NRSLIPNFIEES 292 Query: 385 MRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKE 444 +R+ V +R K T +G + GTV+ + FED H+FR +R Sbjct: 293 LRMDSPVKSDSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDR----- 347 Query: 445 KKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNE---PVEMLH---- 497 N H+ F G C G LA ++ ++L I+ + +A + + P + Sbjct: 348 --PNVREHMAFARGVHSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADDRRYTYE 405 Query: 498 -LGILVPSRELPIAFRP 513 IL EL I F P Sbjct: 406 PTYILRGLTELHITFTP 422 >1UED-A nrPDB Length = 406 Score = 151 bits (382), Expect = 6e-37, Method: Composition-based stats. Identities = 60/407 (14%), Positives = 122/407 (29%), Gaps = 65/407 (15%) Query: 110 GSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYG-LMILEGQEWQRVRSAFQKKLMK 168 G + L E R + K+ + G + + E R+R K++ Sbjct: 60 GYEVVRRILGDHEH-FTTRPQFTQSKSGAHVEAQFVGQISTYDPPEHTRLR-----KMLT 113 Query: 169 PVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQ 228 P ++ +++ + ++ +L + G DL Sbjct: 114 PEFTVRRIRRMEPAIQSLIDDRLDLLEAEGPSADLQGLFA-------------------D 154 Query: 229 KETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDN 288 + + F + + +L + L + + + +DN Sbjct: 155 PVGAHALCELLGIPRDDQREFVRRIRRNADLSRGLKARAADS---------AAFNRYLDN 205 Query: 289 RLQRYSQQPGADFLCDIYQQ--DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNP 346 L R P L I + D+++ +EL T L L VET A + + + L NP Sbjct: 206 LLARQRADPDDGLLGMIVRDHGDNVTDEELKGLCTALILGGVETVAGMIGFGVLALLDNP 265 Query: 347 QAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF-TTRTLDKPTVLG 405 L + + + + E +R V R K V+ Sbjct: 266 GQIELLFESPEKA------------------ERVVNELVRYLSPVQAPNPRLAIKDVVID 307 Query: 406 EYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGR 465 + G + + + E D R + + FG G C+G Sbjct: 308 GQLIKAGDYVLCSILMANRDEALTPDPDVLDANRAAVSD--------VGFGHGIHYCVGA 359 Query: 466 RLAELQLHLALCWIIQKYDIVATDNEPVEM-LHLGILVPSRELPIAF 511 LA L +A + +++ + E+ + ++P+ + Sbjct: 360 ALARSMLRMAYQTLWRRFPGLRLAVPIEEVKYRSAFVDCPDQVPVTW 406 >5Z9I-A nrPDB Length = 398 Score = 151 bits (381), Expect = 6e-37, Method: Composition-based stats. Identities = 49/302 (16%), Positives = 97/302 (32%), Gaps = 39/302 (12%) Query: 222 KRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKV--------WQAHTL 273 +F L+ + L I+ + + + + ++ + K + Sbjct: 121 SQFDLVAEFAAPLPLIMISDLLGVPESDRALFRQWMDKMLDGSEKFESPETVLEQEEELH 180 Query: 274 AWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQD----HLSKKELYAAVTELQLAAVE 329 + ++ R ++P D + + + L+ ++ L + Sbjct: 181 KELELLWEMRDYWHERAAESRKRPREDLISQLVHAEVDGQKLNDSQISNIANRLLVNGHL 240 Query: 330 TTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTP 389 TTA + + L R+ + + A L+ESMR Sbjct: 241 TTAMLIANTMLCLDAFSDQDARVRADRS------------------LVPALLEESMRYMS 282 Query: 390 SVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINP 449 + R + + +PK +L + T E FE F R +P Sbjct: 283 PICGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGR--------SP 334 Query: 450 FAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNE-PVEMLHLGILVPSRELP 508 AHL FG G C+GR+LA ++ A+ ++ + + D P L + LP Sbjct: 335 NAHLGFGRGIHFCLGRQLARMESKAAVEILLDRLPTLRADPANPPTFLQVVDASGVATLP 394 Query: 509 IA 510 + Sbjct: 395 VV 396 >6G5O-A nrPDB Length = 399 Score = 148 bits (374), Expect = 4e-36, Method: Composition-based stats. Identities = 73/451 (16%), Positives = 152/451 (33%), Gaps = 80/451 (17%) Query: 75 WKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYR----TESAHPQRLE 130 K L + A K YG++ ++ L + ++ + A P R+ Sbjct: 2 KKSELPDPFEK-ARESKGYGEMNDQDDP--VTMLLRHKDVRKSAHNYKTFQSGAVPGRIV 58 Query: 131 IKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERM 190 I RD R + + ++ + ++P L + E L + + Sbjct: 59 IPSEVDIRDTRQIPFEVDPPVHGVYRAI--------VEPWFKRPLQAEYQEKLTAQISEI 110 Query: 191 DELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFG 250 E +G + + + ++ L+L E+ T+I+ Sbjct: 111 VEETLLKGSVEVVTDFALRLQSRALTLLL---------NTPFSESETWISW--------- 152 Query: 251 KMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKP-CIDNRLQRYSQQPGADFLCDIYQQD 309 T V+++ A D ++ ID ++ R S+ PG D + + Sbjct: 153 -------------GTHVFRSEGEALDGDKANILYHYIDEQIDRASENPGDDMYSVLLNSE 199 Query: 310 ----HLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQT 365 L+K+E+ + +T N++ + L+ +P+A RL +E + Sbjct: 200 FEGRKLTKEEVKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRKEPE-------- 251 Query: 366 PRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSS 425 ++E +R + R + + T + E+A+ + ++L Sbjct: 252 ----------ITGRAVEEMIRYFSPLTQMGRVVTEDTHVCEHAVKADSRISLCWASANRD 301 Query: 426 EDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQK--- 482 FE+ ++ +R H+ FG C+G A L + L + QK Sbjct: 302 AAVFENPNEIVLDR--------KVNPHVGFGFSHHNCLGATHARQILKILLQTLAQKVAS 353 Query: 483 YDIVATDNEPVEMLHLGILVPSRELPIAFRP 513 ++I+ ++ H V + I F P Sbjct: 354 FEILDYKENIEDLDHFQRKVGFHNIQIKFNP 384 >1UE8-A nrPDB Length = 367 Score = 148 bits (374), Expect = 5e-36, Method: Composition-based stats. Identities = 57/324 (17%), Positives = 110/324 (33%), Gaps = 41/324 (12%) Query: 191 DELCDERGRIPDLYSELNKWSFESICLVLYE--KRFGLLQKETEEEALTFITAIKTMMST 248 DEL + + + + E +L E + F +++ + I+ + + Sbjct: 77 DELRNLTADAFNPSNLPVDFVREVTVKLLSELDEEFDVIESFAIPLPILVISKMLGINPD 136 Query: 249 FGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVK--PCIDNRLQRYSQQPGADFLCDIY 306 K V+ L + K ++ L + D I Sbjct: 137 VKK-----VKDWSDLVALRLGRADEIFSIGRKYLELISFSKKELDSRKGKEIVDLTGKIA 191 Query: 307 QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTP 366 + LS+ E L +A ETT N + + E ++ Sbjct: 192 NSN-LSELEKEGYFILLMIAGNETTTNLIGNAI---------------EDFTLYNSWDYV 235 Query: 367 RAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSE 426 R + ++E++R +P V T R + + + + +G ++ + E Sbjct: 236 REKGALK------AVEEALRFSPPVMRTIRVTKEKVKIRDQVIDEGELVRVWIASANRDE 289 Query: 427 DNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIV 486 + F+D F P+R P HL FG G +C+G LA L+ +AL +K+ + Sbjct: 290 EVFKDPDSFIPDR--------TPNPHLSFGSGIHLCLGAPLARLEARIALEEFAKKFRVK 341 Query: 487 ATDNEPVEMLHLGILVPSRELPIA 510 E + +L R+L + Sbjct: 342 EI--VKKEKIDNEVLNGYRKLVVR 363 >1LG9-A nrPDB Length = 398 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 43/293 (14%), Positives = 94/293 (32%), Gaps = 37/293 (12%) Query: 221 EKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLA------ 274 R +++ L A K + +++ P + + + K+ H A Sbjct: 124 NDRLDEMERAGSPADLIAFVADKVPGAVLCELVGVPRDD-RDMFMKLCHGHLDASLSQKR 182 Query: 275 WDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQ--DHLSKKELYAAVTELQLAAVETTA 332 + + + R ++PG + + + D + +EL ++ LA + + Sbjct: 183 RAALGDKFSRYLLAMIARERKEPGEGMIGAVVAEYGDDATDEELRGFCVQVMLAGDDNIS 242 Query: 333 NSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRL-TPSV 391 + + + R+P+ + QS + + E +R T Sbjct: 243 GMIGLGVLAMLRHPEQIDAFRGDEQSA------------------QRAVDELIRYLTVPY 284 Query: 392 PFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFA 451 T R + L + KG + + D + R P Sbjct: 285 SPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTR--------EPIP 336 Query: 452 HLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPS 504 H+ FG G C+G LA L+L + +++ + +P + + P+ Sbjct: 337 HVAFGHGVHHCLGAALARLELRTVFTELWRRFPALRLA-DPAQDTEFRLTTPA 388 >5NWS-A nrPDB Length = 435 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 45/251 (17%), Positives = 84/251 (33%), Gaps = 32/251 (12%) Query: 252 MMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCID---NRLQRYSQQPGADFLCDIYQQ 308 ++ P +R ++ + + S ID +++ D L ++ + Sbjct: 185 LVGIPATDLERWREWGGDLVSMRPERLRHSFPVMIDYCHRLIEQRRAALTDDLLSELIRA 244 Query: 309 -----DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDN 363 LS E + L LA ET+A+ + L +P L ++ Sbjct: 245 QDDDGGRLSDIETVTMILTLVLAGHETSAHLIGNGTAALLTHPGQWALLRKD-------- 296 Query: 364 QTPRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTLDKPTVLGEYALPKGTVLTLNTQVL 422 L + E MR SV R + L + +G + L Sbjct: 297 ----------PALLPRAVHELMRWCGSVHVARLRYATEDLELAGTPVARGDAVQLVLVSA 346 Query: 423 GSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQK 482 ++ D + R ++ H+ FG G C+G LA + +AL +++ Sbjct: 347 NFDPRHYSDPDRLDITR----HQEGQAENHVGFGHGIHYCLGATLARQEGEVALARLLET 402 Query: 483 Y-DIVATDNEP 492 Y D+ D +P Sbjct: 403 YPDLALADGDP 413 >6FSH-A nrPDB Length = 398 Score = 146 bits (368), Expect = 3e-35, Method: Composition-based stats. Identities = 40/230 (17%), Positives = 81/230 (35%), Gaps = 30/230 (13%) Query: 278 IFKSVKPCIDNRLQRYSQQPGADFLCDIY--QQDHLSKKELYAAVTELQLAAVETTANSL 335 + + + R + PG F+ I D ++ +EL +L LA + + + Sbjct: 186 LGDKFSRYLLAMIARERKDPGDGFIGSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGMI 245 Query: 336 MWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRL-TPSVPFT 394 + L R+P+ L + QS + E +R T T Sbjct: 246 GLGVLALLRHPEQIAALRGDDQSA------------------DRAVDELIRYLTVPYAPT 287 Query: 395 TRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLP 454 RT + ++ + + +G + + + D+ + R P H+ Sbjct: 288 PRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR--------TPVPHVA 339 Query: 455 FGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPS 504 FG G C+G L LQL +A + +++ + +P + + P+ Sbjct: 340 FGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLA-DPAQEIMFRTSTPA 388 >4TX3-A nrPDB Length = 404 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 40/228 (17%), Positives = 82/228 (35%), Gaps = 30/228 (13%) Query: 280 KSVKPCIDNRLQRYSQQPGADFLCDIY--QQDHLSKKELYAAVTELQLAAVETTANSLMW 337 ++ + + R + PG F+ I D ++ +EL +L LA + + + Sbjct: 194 EAFARYLVAMMARERKDPGDGFIGSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGMIGL 253 Query: 338 ILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRL-TPSVPFTTR 396 + L R+P+ L + QS + E +R T T R Sbjct: 254 GVLALLRHPEQIAALRGDDQSA------------------DRAVDELIRYLTVPYAPTPR 295 Query: 397 TLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFG 456 T + ++ + + +G + + + D+ + R P H+ FG Sbjct: 296 TAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR--------TPVPHVAFG 347 Query: 457 IGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPS 504 G C+G L LQL +A + +++ + +P + + P+ Sbjct: 348 HGIHHCLGAALTRLQLRIAYTALWRRFPALQLA-DPAQEIMFRTSTPA 394 >2IAG-A nrPDB Length = 482 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 93/510 (18%), Positives = 175/510 (34%), Gaps = 81/510 (15%) Query: 52 TRNVTSLP---GPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVH 108 TR P G W LG L+ K L +K+G IF + +G Sbjct: 2 TRRPGEPPLDLGSIPW--LGYALDFG-----KDAASFLTRMKEKHGDIFTILVGGRYVTV 54 Query: 109 LGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMK 168 L P +A+ W+ AY + ++E F +L Sbjct: 55 LLDPHSYDAVV--------------WEPRTRLDFHAYAIFLME--------RIFDVQLPH 92 Query: 169 PVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWS-FESICLVLYEKRFGLL 227 + + +L L+ + E L S + + L+ + F L Sbjct: 93 YSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLR 152 Query: 228 QKETEEEALTFITAIKT-----------MMSTFGKMMVTPVELHKRLNTKVWQAHT-LAW 275 + + + TF ++ +L + + + H Sbjct: 153 AGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVK 212 Query: 276 DTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLS-KKELYAAVTELQLAAVETTAN- 333 ++K + P R S+ + + + +E+ A LQL A + Sbjct: 213 SRLWKLLSPARLARRAHRSKW----LESYLLHLEEMGVSEEMQARALVLQLWATQGNMGP 268 Query: 334 SLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAED-------LRNMPYLKACLKESMR 386 + W+L L +NP+A + E++S+L + P ++ L + P L + L ES+R Sbjct: 269 AAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLR 328 Query: 387 LTPSVPFTTRTLDKPTVL-----GEYALPKGTVLTLNTQVL-GSSEDNFEDSHKFRPERW 440 LT PF TR + + E+ L +G L L + + + D F+ R+ Sbjct: 329 LTA-APFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRF 387 Query: 441 LQ----------KEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDN 490 L K+ K ++P+G G C+GR A + + ++ D+ + Sbjct: 388 LNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINA 447 Query: 491 E------PVEMLHLGILVPSRELPIAFRPR 514 + + G++ P ++P+ +R R Sbjct: 448 DVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 477 >3TYW-A nrPDB Length = 417 Score = 142 bits (358), Expect = 3e-34, Method: Composition-based stats. Identities = 63/428 (14%), Positives = 127/428 (29%), Gaps = 70/428 (16%) Query: 95 QIFRMKLGSFDS--VHLGSPSLLEALYR-TESAHPQRLEIKPWKAYRDHRNEAYGLMI-L 150 + R+ L + V + E L SA +R + I Sbjct: 43 PVARVTLPTRREAWVVTRYDDVRELLSDPRVSADIRRPGFPALGEGEQEAGARFRPFIRT 102 Query: 151 EGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKW 210 + E R R + ++ V A E +D + G + + + N Sbjct: 103 DAPEHTRYRRMLLPA----FTVRRVRAMRPAVQARVDEILDGMLAAGGPVDLVSAYANAV 158 Query: 211 SFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQA 270 S IC +L R L F + + + +V +A Sbjct: 159 STSVICELLGIPRHD----------LEFFRDVTRISGS-----------RNSTAEQVSEA 197 Query: 271 HTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQ----DHLSKKELYAAVTELQLA 326 + + V ++P D + + +++ ++L + + A Sbjct: 198 LGGLFGLLGGLV--------AERREEPRDDLISKLVTDHLVPGNVTTEQLLSTLGITINA 249 Query: 327 AVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMR 386 ETT + + L P+ L ++ + A + E +R Sbjct: 250 GRETTTSMIALSTLLLLDRPELPAELRKDPD------------------LMPAAVDELLR 291 Query: 387 LTPSVPFTT-RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEK 445 + R + L +P + + F+D + R Sbjct: 292 VLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHR------ 345 Query: 446 KINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEML--HLGILVP 503 H+ FG G C+G+ LA L+L +AL ++++ + E +++ H Sbjct: 346 --TDNHHVAFGYGVHQCVGQHLARLELEVALETLLRRVPTLRLAGERDQVVVKHDSATFG 403 Query: 504 SRELPIAF 511 EL + + Sbjct: 404 LEELMVTW 411 >5DE9-A nrPDB Length = 410 Score = 142 bits (357), Expect = 5e-34, Method: Composition-based stats. Identities = 60/429 (13%), Positives = 132/429 (30%), Gaps = 72/429 (16%) Query: 94 GQIFRMKLGSFD---SVHLGSPSLLEALYRTESAHPQR---LEIKPWKAYRDHRNEAYGL 147 G + R+ L + + + + L + R ++ + + R + Sbjct: 37 GPVTRISLPNGEGWAWLVTRHDDVR--LVTNDPRF-GREAVMDRQVTRLAPHFRPARGAV 93 Query: 148 MILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYS-E 206 L+ + R+R + + +++ E L+ + + G DL Sbjct: 94 GFLDPPDHTRLRRSVAAAFTA-----RGVERVRERSRGMLDELVDAMLRAGPPADLTEAV 148 Query: 207 LNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTK 266 L+ + IC E + + M T+ +++++ ++ Sbjct: 149 LSPFPIAVIC-----------------ELMGVPATDRHSMHTWTQLILS--------SSH 183 Query: 267 VWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLA 326 + A + + I R + L +D ++ E LQ+ Sbjct: 184 GAEVSERAKNEMNAYFSDLIGLRSDSA-GEDVTSLLGAAVGRDEITLSEAVGLAVLLQIG 242 Query: 327 AVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMR 386 E N+ + + L P+ RL E + + E +R Sbjct: 243 G-EAVTNNSGQMFHLLLSRPELAERLRSEPE------------------IRPRAIDELLR 283 Query: 387 LTP--SVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKE 444 P + +R + + + G + ++ + F D + ER Sbjct: 284 WIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFER----- 338 Query: 445 KKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI--VATDNEPVEMLHLGILV 502 +P H+ FG G C G LA L+ L + ++ + +A E V ++ Sbjct: 339 ---SPNPHVSFGFGPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDVPFKKGALIR 395 Query: 503 PSRELPIAF 511 LP+ + Sbjct: 396 GPEALPVTW 404 >1EHE-A nrPDB Length = 403 Score = 141 bits (355), Expect = 7e-34, Method: Composition-based stats. Identities = 58/362 (16%), Positives = 120/362 (33%), Gaps = 62/362 (17%) Query: 158 VRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICL 217 + + + P + L I + D LE+M ++G + +++ Sbjct: 96 HQRSMVEPTFTPEAVKNLQPYIQRTVDDLLEQM----KQKGCANGPVDLVKEFALPVPSY 151 Query: 218 VLYEKRFGLLQKETEE-EALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWD 276 ++ + LL + E LT AI+T S+ + + A Sbjct: 152 II----YTLLGVPFNDLEYLTQQNAIRTNGSS------------------TAREASAANQ 189 Query: 277 TIFKSVKPCIDNRLQRYSQQPGADFLCDI----YQQDHLSKKELYAAVTELQLAAVETTA 332 + + ++ RL +P D + + + ++ K + L +A T Sbjct: 190 ELLDYLAILVEQRL----VEPKDDIISKLCTEQVKPGNIDKSDAVQIAFLLLVAGNATMV 245 Query: 333 NSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVP 392 N + + L+++P +L N ++E R + Sbjct: 246 NMIALGVATLAQHPDQLAQLKA------------------NPSLAPQFVEELCRYHTASA 287 Query: 393 F-TTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFA 451 RT + ++G+ + + + Q E+ FE+ +F R K P Sbjct: 288 LAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNR------KWPPQD 341 Query: 452 HLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILV--PSRELPI 509 L FG G CI LA+ +L + QK+ + ++ + + +LP+ Sbjct: 342 PLGFGFGDHRCIAEHLAKAELTTVFSTLYQKFPDLKVAVPLGKINYTPLNRDVGIVDLPV 401 Query: 510 AF 511 F Sbjct: 402 IF 403 >2X9P-A nrPDB Length = 404 Score = 141 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 66/434 (15%), Positives = 137/434 (31%), Gaps = 68/434 (15%) Query: 86 LAEYHKKYGQIFRMK--LGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNE 143 L + G I R++ G + L + L+ R P A + R+ Sbjct: 31 LLRALQDRGPIHRVRTPAGDEAWLVTRHAELKQLLHD---ERIGRTHPDPPSAAQYVRSP 87 Query: 144 AYGLMILEGQEWQRVRSAF-QKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPD 202 L+I + R ++L+ P+ + ++ + + + + + +G D Sbjct: 88 FLDLLISDADAESGRRQHAETRRLLTPLFSARRVLEMQPKVEEAADTLLDAFIAQGPPGD 147 Query: 203 LYSELN-KWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHK 261 L+ EL ++ +C V+ + + E T + I + G Sbjct: 148 LHGELTVPFALTVLCEVIG------VPPQRRAELTTLLAGIAKLDDREGA---------- 191 Query: 262 RLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVT 321 A D +F V ++ +PG D + + L++ + Sbjct: 192 ----------VRAQDDLFGYVAGL----VEHKRAEPGPDIISRL-NDGELTEDRVAHLAM 236 Query: 322 ELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACL 381 L A +++ A+ + + L+ +P + L + + + Sbjct: 237 GLLFAGLDSVASIMDNGVVLLAAHPDQRAAALADPD------------------VMARAV 278 Query: 382 KESMR--LTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPER 439 +E +R R + G + G ++ + + E F +F R Sbjct: 279 EEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAFTGPEEFDAAR 338 Query: 440 WLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIV--ATDNEPVEMLH 497 P HL FG G CIG LA L+L + + + E + + Sbjct: 339 --------TPNPHLTFGHGIWHCIGAPLARLELRTMFTKLFTRLPELRPELPVEQLRLKE 390 Query: 498 LGILVPSRELPIAF 511 + EL + + Sbjct: 391 GQLSGGFAELRVVW 404 >2FR7-A nrPDB Length = 412 Score = 140 bits (353), Expect = 1e-33, Method: Composition-based stats. Identities = 39/207 (18%), Positives = 72/207 (34%), Gaps = 27/207 (13%) Query: 307 QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTP 366 ++ +E V L A ++TT N + +Y L+R P RL + Sbjct: 232 DTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRADPS--------- 282 Query: 367 RAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSE 426 + +E++R V RT + L + +G + + Sbjct: 283 ---------LARNAFEEAVRFESPVQTFFRTTTRDVELAGATIGEGEKVLMFLGSANRDP 333 Query: 427 DNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIV 486 ++D ++ R H+ FG G MC+G+ +A L+ + L + +K + Sbjct: 334 RRWDDPDRYDITR--------KTSGHVGFGSGVHMCVGQLVARLEGEVVLAALARKVAAI 385 Query: 487 ATDNEPVEMLHLGILVPSRELPIAFRP 513 P++ L LPI P Sbjct: 386 EIAG-PLKRRFNNTLRGLESLPIQLTP 411 >1Q5D-A nrPDB Length = 419 Score = 139 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 72/434 (16%), Positives = 135/434 (31%), Gaps = 63/434 (14%) Query: 77 GGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKA 136 G + + + IF G S L + A++R E R E + Sbjct: 23 GYAEDPFPAIERLREA-TPIFYWDEG--RSWVLTRYHDVSAVFRDERFAVSREEWESSAE 79 Query: 137 YRD-----HRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMD 191 Y + YGL L ++ RVR + + + ++++ Sbjct: 80 YSSAIPELSDMKKYGLFGLPPEDHARVRKLVNPSFTS-----RAIDLLRAEIQRTVDQLL 134 Query: 192 ELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGK 251 + + + +I +L + E +E+ F +A + Sbjct: 135 DARSGQEEFDVVRDYAEGIPMRAISALL------KVPAECDEKFRRFGSATARALGV--- 185 Query: 252 MMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQD-- 309 L +V + ++ + + +R D L + Q + Sbjct: 186 ----------GLVPRVDEETKTLVASVTEGLALLHGVLDERRRNPLENDVLTMLLQAEAD 235 Query: 310 --HLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPR 367 LS KEL A V + A +TT + + + NL R+P+A + E Sbjct: 236 GSRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAE------------ 283 Query: 368 AEDLRNMPYLKACLKESMRLTPSV-PFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSE 426 ++ L E +R + T R + ++ KG ++ L Sbjct: 284 ------PGLMRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIPSALRDG 337 Query: 427 DNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIV 486 F F R + A L +G G +C G LA L+ +A+ I +++ + Sbjct: 338 TVFSRPDVFDVRR--------DTSASLAYGRGPHVCPGVSLARLEAEIAVGTIFRRFPEM 389 Query: 487 ATDNEPVEMLHLGI 500 PV H Sbjct: 390 KLKETPVFGYHPAF 403 >5HDI-A nrPDB Length = 404 Score = 139 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 42/218 (19%), Positives = 76/218 (34%), Gaps = 28/218 (12%) Query: 281 SVKPCIDNRLQRYSQQPGADFLCDIYQQ---DHLSKKELYAAVTELQLAAVETTANSLMW 337 + I + R + P + L ++ L + L A E+TA L Sbjct: 196 ELSGYIFEQFDRAAADPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGESTAALLGS 255 Query: 338 ILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRT 397 ++ L+ P Q+++ + L A ++E++R P R Sbjct: 256 AVWILATRPDIQQQVRANPE------------------LLGAFIEETLRYEPPFRGHYRH 297 Query: 398 LDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGI 457 + T L LP + L L FE +FR +R K H+ FG Sbjct: 298 VRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKG-------HISFGK 350 Query: 458 GKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEM 495 G C+G LA L+ + L ++ + ++ + + Sbjct: 351 GAHFCVGAALARLEARIVLRLLLDRTSVIEAADVGGWL 388 >5D3U-A nrPDB Length = 427 Score = 138 bits (348), Expect = 5e-33, Method: Composition-based stats. Identities = 69/391 (17%), Positives = 121/391 (30%), Gaps = 49/391 (12%) Query: 122 ESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINE 181 + P + + P + +M + +R + + + D+ + + Sbjct: 86 AAKFPGQP-LPPDNIFHRWTKNV--VMYTDPPLHDALRRSVRAGFTR-AAHQHYDQVLQK 141 Query: 182 VLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITA 241 V D + + E D L + + EE+ I Sbjct: 142 VAHDLVASIPAGATE----IDAVPALAAELPVRSAVHAFGV--------PEEDLGFLIPR 189 Query: 242 IKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADF 301 + T+M+ F PV + + K+ HT A + + + + + Sbjct: 190 VNTIMTYFSGPKDQPVT-QEIILEKLTDLHTYASELLQGMRGKVLPDTVIARLAAAQDGL 248 Query: 302 LCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLP 361 +Q + +L L TT SL +RNP+ R L + V Sbjct: 249 TETTPEQ---TVHQLALVFIALFAP---TTPGSLSSGTLAFARNPRQVERFLADQACV-- 300 Query: 362 DNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQV 421 E +R S FT R K +G + G L L Sbjct: 301 ----------------DNTANEVLRYNASNQFTWRVAAKDVEMGGVRIEAGQTLALFLGS 344 Query: 422 LGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQ 481 + FE + F +R N HL FG G C+ +L LQL ++ Sbjct: 345 ANRDANMFERPNDFDLDR-------PNSARHLSFGQGVHACLAAQLISLQLKWFYVALLN 397 Query: 482 KYDIVATDNEPVEMLHLGILVPSRELPIAFR 512 ++ + T EP+ +L R LP++ R Sbjct: 398 RFPGIRTAGEPIWNENLEF-RSLRSLPLSLR 427 >2UUQ-A nrPDB Length = 414 Score = 138 bits (347), Expect = 6e-33, Method: Composition-based stats. Identities = 37/231 (16%), Positives = 72/231 (31%), Gaps = 33/231 (14%) Query: 289 RLQRYSQQPGADFLCDIYQQDHLSKKE------LYAAVTELQLAAVETTANSLMWILYNL 342 ++R +P D + + + + + A + +T L + L Sbjct: 207 LIERRRTEPADDAISHLVAAGVGADGDTAGTLSILAFTFTMVTGGNDTVTGMLGGSMPLL 266 Query: 343 SRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPT 402 R P +R LL + + + ++E +RLT V RT + Sbjct: 267 HRRPDQRRLLLDDPEGI------------------PDAVEELLRLTSPVQGLARTTTRDV 308 Query: 403 VLGEYALPKGTVLTLNTQVLGSSEDNF-EDSHKFRPERWLQKEKKINPFAHLPFGIGKRM 461 +G+ +P G + L E + D+ + R P L F G Sbjct: 309 TIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTRC--------PRNILTFSHGAHH 360 Query: 462 CIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFR 512 C+G A +Q +AL ++ + + + +P Sbjct: 361 CLGAAAARMQCRVALTELLARCPDFEVAESRIVWSGGSYVRRPLSVPFRVT 411 >3A1L-A nrPDB Length = 425 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 37/200 (18%), Positives = 62/200 (31%), Gaps = 26/200 (13%) Query: 307 QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTP 366 LS + L A ETT N L + L + L +S Sbjct: 235 TGSPLSVDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELRTTPES-------- 286 Query: 367 RAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSE 426 A ++E MR P V TR + LG++ +P+G+ + Sbjct: 287 ----------TPAAVEELMRYDPPVQAVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDP 336 Query: 427 DNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIV 486 F D R +++ + FG+G C+G LA + + L ++ + Sbjct: 337 ARFPDPDVLDVHRAAERQ--------VGFGLGIHYCLGATLARAEAEIGLRALLDGIPAL 388 Query: 487 ATDNEPVEMLHLGILVPSRE 506 VE + Sbjct: 389 GRGAHEVEYADDMVFHGPTR 408 >4DO1-A nrPDB Length = 410 Score = 136 bits (342), Expect = 3e-32, Method: Composition-based stats. Identities = 41/207 (19%), Positives = 72/207 (34%), Gaps = 27/207 (13%) Query: 307 QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTP 366 ++ E V L A ++TT N + +Y L+R P +RL Sbjct: 230 DTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLR------------- 276 Query: 367 RAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSE 426 + + +E++R V RT + LG + +G + + Sbjct: 277 -----SDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDP 331 Query: 427 DNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIV 486 + D + R H+ FG G MC+G+ +A L+ + L + +K + Sbjct: 332 RRWSDPDLYDITR--------KTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAI 383 Query: 487 ATDNEPVEMLHLGILVPSRELPIAFRP 513 D PV+ L LP+ P Sbjct: 384 DIDG-PVKRRFNNTLRGLESLPVKLTP 409 >1WIY-A nrPDB Length = 389 Score = 135 bits (341), Expect = 3e-32, Method: Composition-based stats. Identities = 92/441 (20%), Positives = 160/441 (36%), Gaps = 68/441 (15%) Query: 74 FWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKP 133 + K + L E+ + + ++F + L F + P +E E + + Sbjct: 12 YLKDLQQDPLAVLLEWGRAHPRLF-LPLPRFPLALIFDPEGVEGALLAEGTTKATFQYRA 70 Query: 134 WKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDEL 193 GL+ G+ W+ R A + + P + + + E F Sbjct: 71 LSRLTGR-----GLLTDWGKSWKEARKALKDPFL-PKSVRGYREAMEEEAWAF------F 118 Query: 194 CDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMM 253 + RG DL E+ S + L+ K + A + A+ +M+ Sbjct: 119 GEWRGEERDLDHEMLALSLRLLGRALFGK------PLSPSLAEHALKALDRIMAQT---- 168 Query: 254 VTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSK 313 L+ +++ + I + HL + Sbjct: 169 ---RSPLALLDLAAEARFRKDRGALYREAEALIVHPPL-----------------SHLPR 208 Query: 314 KELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRN 373 + + L +A ET A++L W LS P Q+R+ + ++ L Q Sbjct: 209 ERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRVAESEEAALAAFQ--------- 259 Query: 374 MPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSH 433 E++RL P TR L++P +LGE LP+GT L L+ V F + Sbjct: 260 ---------EALRLYPPAWILTRRLERPLLLGEDRLPQGTTLVLSPYVTQR--LYFPEGE 308 Query: 434 KFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPV 493 F+PER+L E+ + PFG+G+R+C+GR A L+ + L +++ + V Sbjct: 309 AFQPERFL-AERGTPSGRYFPFGLGQRLCLGRDFALLEGPIVLRAFFRRFRLDPLPFPRV 367 Query: 494 EMLHLGILVPSRELPIAFRPR 514 L L P LP RPR Sbjct: 368 --LAQVTLRPEGGLP--ARPR 384 >6GII-A nrPDB Length = 479 Score = 135 bits (339), Expect = 5e-32, Method: Composition-based stats. Identities = 40/231 (17%), Positives = 79/231 (34%), Gaps = 28/231 (12%) Query: 286 IDNRLQRYSQQPG---ADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNL 342 + +++R + PG D ++ L++ + + +AA ETT + L L Sbjct: 265 VLEKMRRTADGPGWMRYSIRQQKLYPDVVTDSYLHSMMQAIIVAAHETTVFATTNALKTL 324 Query: 343 SRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPT 402 + R + + + A +E +R V R + Sbjct: 325 LEHETVWREICADPS------------------LIPAAAEECLRYNGPVAGWRRRTTREV 366 Query: 403 VLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMC 462 + LP G + + +F+D F R N HL FG G C Sbjct: 367 EVEGVRLPVGANILMVVASANHDSAHFDDPEFFDIGR-------SNASEHLNFGYGAHQC 419 Query: 463 IGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRP 513 +GR L +++ + + + ++ + + + LH R L + + P Sbjct: 420 LGRNLGRMEMQIMIEELSRRLPHMRLAEQRFDYLHNVSFRAPRHLWVEWDP 470 >6M7L-A nrPDB Length = 404 Score = 134 bits (338), Expect = 7e-32, Method: Composition-based stats. Identities = 38/234 (16%), Positives = 77/234 (32%), Gaps = 35/234 (14%) Query: 284 PCIDNRLQRYSQQPGADFLCDIYQQ--DHLSKKELYAAVTELQLAAVETTANSLMWILYN 341 + R + PG L + + +S +EL + ++VE T + L Sbjct: 200 AYMRELAARLRRDPGDGMLGMVARDHGADISDEELAGLCAVVMNSSVEQTESCLAAGTLL 259 Query: 342 LSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDK 400 L +P+ L + + + ++E +R RT + Sbjct: 260 LLEHPEQFALLRERPE------------------LGEQAVEEIVRYLSVFEGLDPRTATE 301 Query: 401 PTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKR 460 +G + KG + + ++ F R H+ FG G Sbjct: 302 DVEIGGQVIKKGEAVFCSLLAANRADPAL---DGFDITR--------KESRHVAFGHGIH 350 Query: 461 MCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLH---LGILVPSRELPIAF 511 C+G LA ++L +A ++ ++ + T E+ + ELP+ + Sbjct: 351 HCLGAPLARMELRIAFTTLVSRFPSLRTAVPAEEIRFRPPSSNVFTLLELPLTW 404 >5LIV-A nrPDB Length = 450 Score = 134 bits (337), Expect = 9e-32, Method: Composition-based stats. Identities = 65/374 (17%), Positives = 131/374 (35%), Gaps = 64/374 (17%) Query: 146 GLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKK-INEVLADFLERMDELCDERGRI-PDL 203 GL ++G E R+R + P + + +++ + + ++R+ G+ DL Sbjct: 122 GLAAMQGDEHARMRRVYN-MFFLPRAVSQYEERFVRPISEQVVDRLA------GKPRVDL 174 Query: 204 YSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRL 263 + + E V+ + FG ++ E ++ ++ Sbjct: 175 LEDF---AMELPRRVI-GELFGFPAEKLHETDERVRAMLRGLVRMHDP------------ 218 Query: 264 NTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQ---QDHL-SKKELYAA 319 A + I ++R S+ L +I + +H+ + + Sbjct: 219 ------AAVAESQRAYGETLGLITEVVERESRDTSDTLLGEILRTLKAEHMDTIEASRQI 272 Query: 320 VTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKA 379 V L L ETT+ + ++ L +P R+ Q+ L A Sbjct: 273 VLSLILGGYETTSWLVANTIHALLAHPDTLARVRQDPS------------------LLPA 314 Query: 380 CLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPER 439 ++E MR PS R +++ L + AL GTV+ L E + + +R Sbjct: 315 AIEEGMRWCPSSFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDR 374 Query: 440 WLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLG 499 K P A++ FG G C+G LA ++ + L ++ ++ + E G Sbjct: 375 ------KPLPAANV-FGGGAHFCVGAPLARMEARVGLQALLARFPGLRAVPEERPSFMYG 427 Query: 500 ----ILVPSRELPI 509 + +LP+ Sbjct: 428 AKDSVAHGPDKLPV 441 >3OFT-A nrPDB Length = 396 Score = 134 bits (337), Expect = 1e-31, Method: Composition-based stats. Identities = 51/286 (17%), Positives = 101/286 (35%), Gaps = 35/286 (12%) Query: 237 TFITAIKTMMS--TFGKMMVTPVELHKRLNTKVWQAHT----LAWDTIFKSVKPCIDNRL 290 F++ ++ F ++ P+E RL Q + + + ++ + + Sbjct: 135 DFVSDFAEILPLNIFLTLIDVPLEDRPRLRQLGVQLTRPDGSMTVEQLKQAADDYLWPFI 194 Query: 291 QRYSQQPGADF----LCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNP 346 ++ QPG D L + + E L ++T A + + +L+R+P Sbjct: 195 EKRMAQPGDDLFSRILSEPVGGRPWTVDEARRMCRNLLFGGLDTVAAMIGMVALHLARHP 254 Query: 347 QAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGE 406 + QR L + + A E MR P+V +R Sbjct: 255 EDQRLLRERPD------------------LIPAAADELMRRYPTVA-VSRNAVADVDADG 295 Query: 407 YALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRR 466 + KG ++ L + + +FE + R +R L P H G+G C+G Sbjct: 296 VTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGLA------PIRHTTMGVGAHRCVGAG 349 Query: 467 LAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFR 512 LA +++ + L + A + + G + LP+ +R Sbjct: 350 LARMEVIVFLREWLGGMPEFALAPDKAVTMKGGNVGACTALPLVWR 395 >6F88-A nrPDB Length = 400 Score = 134 bits (337), Expect = 1e-31, Method: Composition-based stats. Identities = 65/374 (17%), Positives = 131/374 (35%), Gaps = 64/374 (17%) Query: 146 GLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKK-INEVLADFLERMDELCDERGRI-PDL 203 GL ++G E R+R + P + + +++ + + ++R+ G+ DL Sbjct: 72 GLAAMQGDEHARMRRVYN-MFFLPRAVSQYEERFVRPISEQVVDRLA------GKPRVDL 124 Query: 204 YSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRL 263 + + E V+ + FG ++ E ++ ++ Sbjct: 125 LEDF---AMELPRRVI-GELFGFPAEKLHETDERVRAMLRGLVRMHDP------------ 168 Query: 264 NTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQ---QDHL-SKKELYAA 319 A + I ++R S+ L +I + +H+ + + Sbjct: 169 ------AAVAESQRAYGETLGLITEVVERESRDTSDTLLGEILRTLKAEHMDTIEASRQI 222 Query: 320 VTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKA 379 V L L ETT+ + ++ L +P R+ Q+ L A Sbjct: 223 VLSLILGGYETTSWLVANTIHALLAHPDTLARVRQDPS------------------LLPA 264 Query: 380 CLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPER 439 ++E MR PS R +++ L + AL GTV+ L E + + +R Sbjct: 265 AIEEGMRWCPSNFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDR 324 Query: 440 WLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLG 499 K P A++ FG G C+G LA ++ + L ++ ++ + E G Sbjct: 325 ------KPLPAANV-FGGGAHFCVGAPLARMEARVGLQALLARFPGLRAVPEERPSFMYG 377 Query: 500 ----ILVPSRELPI 509 + +LP+ Sbjct: 378 AKDSVAHGPDKLPV 391 >2WIY-A nrPDB Length = 394 Score = 133 bits (334), Expect = 2e-31, Method: Composition-based stats. Identities = 33/236 (13%), Positives = 71/236 (30%), Gaps = 28/236 (11%) Query: 279 FKSVKPCIDNRLQRYSQQPGADFLCDIY---QQDHLSKKELYAAVTELQLAAVETTANSL 335 F + + L+ PG + + +++ E A + + Sbjct: 183 FGYLSARVAEMLEDKRVNPGDGLADSLLDAARAGEITESEAIATILVFYAVGHMAIGYLI 242 Query: 336 MWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT 395 + +R P+ + + A + E +R+ P Sbjct: 243 ASGIELFARRPEVFTAFRNDESARA------------------AIINEMVRMDPPQLSFL 284 Query: 396 RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPF 455 R + +G + G+ + + F+D F R +L F Sbjct: 285 RFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTR------PPAASRNLSF 338 Query: 456 GIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAF 511 G+G C G+ ++ + + ++Y+ + EP + H R+LPI Sbjct: 339 GLGPHSCAGQIISRAEATTVFAVLAERYERIELAEEPT-VAHNDFARRYRKLPIVL 393 >6BLD-A nrPDB Length = 419 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 38/224 (16%), Positives = 68/224 (30%), Gaps = 30/224 (13%) Query: 292 RYSQQPGADFLCDIY----QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQ 347 +PG D + D L+ ++ A L +A +TT ++ L L+ P Sbjct: 222 ERRDRPGDDLFSALVNAEVDGDRLADADVAAFFVLLAVAGNDTTRQTISHGLKALTDFPS 281 Query: 348 AQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEY 407 + LL + + + ++E +R V RT LG Sbjct: 282 QKAWLLADFDTRIG-----------------TAVEELVRWATPVMTFRRTAAADFELGGQ 324 Query: 408 ALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRL 467 + G + + ED F + R C+G L Sbjct: 325 LIRAGEKVVMFYASGNWDEDAFCHPERLDLSRSPNPHVGFGGGGVH-------FCLGAHL 377 Query: 468 AELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAF 511 A QL ++ + + +PV + + R +P F Sbjct: 378 ARAQLRAIFGELLVQLPDIQ-AGDPV-YVPGNFVHAIRSMPCTF 419 >5HIW-A nrPDB Length = 398 Score = 129 bits (323), Expect = 4e-30, Method: Composition-based stats. Identities = 70/392 (17%), Positives = 125/392 (31%), Gaps = 67/392 (17%) Query: 103 SFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAF 162 + + + A+ R R D L+ L G+ R+R F Sbjct: 36 GLGVPVVLRGADVVAVLRDSETFSTRT--------YDTGIMKGALVTLGGEAHTRMRRLF 87 Query: 163 QKKLMKPVEIMKLDKK-INEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYE 221 ++ P I + ++ + V +ER+ + ER + D + + L+ Sbjct: 88 N-AVLSPRVISRYEEATVTPVARRVVERL--VRKERAELFD---DFAISMPMGVTSALFG 141 Query: 222 KRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKS 281 EE + A+ M M PV + + + Sbjct: 142 ---------LPEERIAENDALIRKMIRSVVMPQDPVVVAEGRSAHAAMEAQ--------- 183 Query: 282 VKPCIDNRLQRYSQQPGADFLCDI---YQQDHLSKKELY-AAVTELQLAAVETTANSLMW 337 + +R P L +I + L E V L L + ETT+ L Sbjct: 184 ----LREIAEREVAHPSDTLLGEIARAIVAEGLGGVEACEGVVLTLILGSYETTSWMLAN 239 Query: 338 ILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRT 397 +L L +P A +L Q L ++ES R S R Sbjct: 240 LLVALLAHPDAMNQLRQ------------------QPSLLPQAIEESTRWCSSAAGIVRF 281 Query: 398 LDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGI 457 +++ +G L GT+L L+ E+ + F R P L FG Sbjct: 282 VEREATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDIHR--------RPVGMLNFGG 333 Query: 458 GKRMCIGRRLAELQLHLALCWIIQKYDIVATD 489 G C+G LA ++ + + +++++ + D Sbjct: 334 GLHYCVGAPLARMEARVGVSLLLERFPALRAD 365 >4FB2-A nrPDB Length = 398 Score = 129 bits (323), Expect = 4e-30, Method: Composition-based stats. Identities = 46/269 (17%), Positives = 88/269 (32%), Gaps = 35/269 (13%) Query: 251 KMMVTPVELHKRLNTKVWQ-AHTLAWDT---IFKSVKPCIDNRLQRYSQQPGADFLCDIY 306 ++ P E VW H + IF + + PG D + + Sbjct: 149 ILLGLPPEDGDTYRRWVWAITHVENPEEGAEIFAELVAHARTLIAERRTNPGNDIMSRVI 208 Query: 307 ----QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPD 362 + LS+ +L T L L ++ TA L + + L+ + + +RRL+ Sbjct: 209 MSKIDGESLSEDDLIGFFTILLLGGIDNTARFLSSVFWRLAWDIELRRRLIA-------- 260 Query: 363 NQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVL 422 + + + E +R R + + +G+ + G L + Sbjct: 261 ----------HPELIPNAVDELLRFYGPAMVG-RLVTQEVTVGDITMKPGQTAMLWFPIA 309 Query: 423 GSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQK 482 F+ ER P HL G G C+G L ++ +A+ +++ Sbjct: 310 SRDRSAFDSPDNIVIER--------TPNRHLSLGHGIHRCLGAHLIRVEARVAITEFLKR 361 Query: 483 YDIVATDNEPVEMLHLGILVPSRELPIAF 511 + D +G + +PI F Sbjct: 362 IPEFSLDPNKECEWLMGQVAGMLHVPIIF 390 >5KYO-A nrPDB Length = 430 Score = 124 bits (312), Expect = 7e-29, Method: Composition-based stats. Identities = 58/395 (14%), Positives = 123/395 (31%), Gaps = 42/395 (10%) Query: 132 KPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK-----LDKKINEVLADF 186 + W+ G W +RS + +M E + K+ Sbjct: 61 QSWREIMRQAPHPLMWTPHNGGHWVALRSDLAETVMSDFERFSNHTVLVPKETAGEAYRL 120 Query: 187 LERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMM 246 + + + R L L I V+ + L++ + F + Sbjct: 121 IPLSLDPPEHRPFRSLLNENLGPKPLRPIEQVVTDLAVSLIEGFRPKGRCNFTHEFAEQL 180 Query: 247 S--TFGKMMVTPVELHKRLN----TKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGAD 300 F +++ PVE +L ++ D + K + + ++ +PG D Sbjct: 181 PVRIFMRIVDLPVEDLPKLKHLADQYTRPDGSIPLDDVTKQFREYLRPVIEARRIKPGED 240 Query: 301 FLCDIYQQD----HLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEV 356 + + + L+ E ++ + ++T N L + +L+++ +R + + Sbjct: 241 MISRMINGEVGGRPLTDIEAENICIQVLVGGLDTVVNMLGFTFSHLAKDHALRRAIAADP 300 Query: 357 QSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLT 416 + L E R P V R + + L G ++ Sbjct: 301 S------------------LIDDALLEFFRRFPVVSS-AREVLRDQEFEGVLLKAGDMVM 341 Query: 417 LNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLAL 476 T V+ + ED +FR R H FG G C G LA +++ + L Sbjct: 342 APTVVVAMDDARNEDPLEFRLGR--------KARQHSTFGKGSHTCPGAHLARMEMKVVL 393 Query: 477 CWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAF 511 + +++ GI+ + + + Sbjct: 394 REWFARIPEFRIEDDAPLRYSNGIVGSVKPFVLEW 428 >6G71-A nrPDB Length = 405 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 39/235 (16%), Positives = 76/235 (32%), Gaps = 29/235 (12%) Query: 280 KSVKPCIDNRLQRYSQQPGADFLCDIYQQD--HLSKKELYAAVTELQLAAVETTANSLMW 337 + ++ +Q +S +PG L + + + + + + + + + L Sbjct: 188 DEIDAALEEMIQWHSGRPGDSLLSYLLRSADYQMPLESIRSNIKMTIGGGLNEPRDVLGV 247 Query: 338 ILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRT 397 L + + + LR+ A +ES+R + R Sbjct: 248 STLALLSSSKQLELV------------------LRDPKLWGAVFEESIRWVAPIGMVPRQ 289 Query: 398 LDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGI 457 T L Y +P+G L L + D +F ER + AHL FG Sbjct: 290 TVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRFDIERGSE--------AHLAFGK 341 Query: 458 GKRMCIGRRLAELQLH-LALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAF 511 G +C+G A Q+ + L + + + D + LP+ + Sbjct: 342 GVHVCLGAWAARSQVADVGLPALFSRLKGLRLDPNQEATHGGWVFRGPLSLPLVW 396 >3WEC-A nrPDB Length = 419 Score = 120 bits (302), Expect = 1e-27, Method: Composition-based stats. Identities = 45/285 (15%), Positives = 90/285 (31%), Gaps = 39/285 (13%) Query: 230 ETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNR 289 E L + S + ++ ++++ + +V + A + + Sbjct: 159 EVLSSILGIPDKDRGRFSEWSNLVAGVLDINFAIPKEVADRRSAAIEESIDYFRTL---- 214 Query: 290 LQRYSQQPGADFLCDIYQ----QDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRN 345 S + + + D LS E+ A + +A ETT+N++ +L SR+ Sbjct: 215 --ATSGNAPEGLVRRLSEVSHGGDQLSVDEIAATCLLITVAGQETTSNTIGNMLITFSRH 272 Query: 346 PQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLG 405 ++ N +++ + E +R P R + + Sbjct: 273 ADQFEQVRA------------------NPQFIENAVAEVLRFEPPAHEAGRIALEDCEVS 314 Query: 406 EYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGR 465 + KG + + + E F R + L +G G C+G Sbjct: 315 GANITKGDAVMVLLASGNR--EAVERGDTFSVTR--------PDVSSLSYGRGIHHCLGS 364 Query: 466 RLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIA 510 LA L L + Q+Y + EP+ L L +A Sbjct: 365 ALANSMLQHFLRELSQRYRSIEVA-EPINYKPGMGLRGPETLSVA 408 >2NZA-A nrPDB Length = 413 Score = 120 bits (302), Expect = 1e-27, Method: Composition-based stats. Identities = 39/246 (15%), Positives = 78/246 (31%), Gaps = 34/246 (13%) Query: 273 LAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDI---YQQDHLSKKELYAAVTELQLAAVE 329 A + + + I ++ + G D + + + + E LQ+ E Sbjct: 189 EAAERAKRGLYGWITETVRARAGSEGGDVYSMLGAAVGRGEVGETEAVGLAGPLQIGG-E 247 Query: 330 TTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTP 389 +++ +LY L + R+ E L E +R Sbjct: 248 AVTHNVGQMLYLLLTRRELMARMR-ERPGARG-----------------TALDELLRWIS 289 Query: 390 --SVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKI 447 + R + + + G + ++ D F D + +R Sbjct: 290 HRTSVGLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDR-------- 341 Query: 448 NPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYD--IVATDNEPVEMLHLGILVPSR 505 +P HL +G G C G LA +Q L + ++++ +A E V ++ R Sbjct: 342 DPNPHLAYGNGHHFCTGAVLARMQTELLVDTLLERLPGLRLAVPAEQVAWRRKTMIRGPR 401 Query: 506 ELPIAF 511 LP + Sbjct: 402 TLPCTW 407 >3BUJ-A nrPDB Length = 397 Score = 119 bits (297), Expect = 4e-27, Method: Composition-based stats. Identities = 46/220 (20%), Positives = 76/220 (34%), Gaps = 30/220 (13%) Query: 298 GADFLCDIYQQDH---LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQ 354 G D L + +S+ E+ + V ET A+ + + +L +P L + Sbjct: 202 GEDLLALMLDAHDRGLMSRNEIVSTVVTFIFTGHETVASQVGNAVLSLLAHPDQLDLLRR 261 Query: 355 EVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTV 414 L ++E +R PSV TR LD L L + V Sbjct: 262 RPD------------------LLAQAVEECLRYDPSVQSNTRQLDVDVELRGRRLRRDDV 303 Query: 415 LTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHL 474 + + ++ F ER +P + FG G R C+G LA QL Sbjct: 304 VVVLAGAANRDPRRYDRPDDFDIER--------DPVPSMSFGAGMRYCLGSYLARTQLRA 355 Query: 475 ALCWIIQKYDIVA-TDNEPVEMLHLGILVPSRELPIAFRP 513 A+ + + + ++ + + LPIAF P Sbjct: 356 AVAALARLPGLRLGCASDALAYQPRTMFRGLASLPIAFTP 395 >3OO3-A nrPDB Length = 384 Score = 118 bits (296), Expect = 5e-27, Method: Composition-based stats. Identities = 41/232 (17%), Positives = 70/232 (30%), Gaps = 38/232 (16%) Query: 282 VKPCIDNRLQRYSQQPGADFLCDIYQQ--DHLSKKELYAAVTELQLAAVETTANSLMWIL 339 + + PG + I ++ +S +EL + A E A L + Sbjct: 180 IVNYTKRLTSGKRRDPGDGMIGVIVREHGAEISDEELAGLAEGNLIMAAEQMAAQLAVAV 239 Query: 340 YNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF-TTRTL 398 L +P L + + + +E +R V R Sbjct: 240 LLLVTHPDQMALLRE------------------KPELIDSATEEVLRHASIVEAPAPRVA 281 Query: 399 DKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIG 458 + + G VLT + + +F R H+ FG G Sbjct: 282 LADVRMAGRDIHAGDVLTCSMLATNRAP-----GDRFDITR--------EKATHMAFGHG 328 Query: 459 KRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIA 510 CIG LA LQL +AL ++ ++ + ++ P R P A Sbjct: 329 IHHCIGAPLARLQLRVALPAVVGRFPSLRLAVPEEDLR----FKPGRPAPFA 376 >2QBO-A nrPDB Length = 421 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 56/405 (13%), Positives = 133/405 (32%), Gaps = 69/405 (17%) Query: 113 SLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEI 172 L+ Y P +A + + E ++ R+ + + PV + Sbjct: 70 QLIREAYEDYRHFSSECPFIPREAGEAYDFIPTSMDP---PEQRQFRALANQVVGMPV-V 125 Query: 173 MKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETE 232 KL+ +I E+ +E + +G+ + + + Sbjct: 126 DKLENRIQELACSLIESLR----PQGQ------------------CNFTEDY-------- 155 Query: 233 EEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQR 292 A F I +++ + + ++ T+ + + +++ + +++ Sbjct: 156 --AEPFPIRIFMLLAGLPEEDIPHLKYLTDQMTRPDGSM--TFAEAKEALYDYLIPIIEQ 211 Query: 293 YSQQPGADFLCDI----YQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQA 348 Q+PG D + + ++ E L + ++T N L + + L+++P+ Sbjct: 212 RRQKPGTDAISIVANGQVNGRPITSDEAKRMCGLLLVVGLDTVVNFLSFSMEFLAKSPEH 271 Query: 349 QRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYA 408 ++ L++ + + A +E +R V R L Sbjct: 272 RQELIERPERI------------------PAACEELLRRFSLVADG-RILTSDYEFHGVQ 312 Query: 409 LPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLA 468 L KG + L + G E + + +H FG G +C+G+ LA Sbjct: 313 LKKGDQILLPQMLSGLDERENACP--------MHVDFSRQKVSHTTFGHGSHLCLGQHLA 364 Query: 469 ELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRP 513 ++ + L + + + GI+ + LP+ + P Sbjct: 365 RREIIVTLKEWLTRIPDFSIAPGAQIQHKSGIVSGVQALPLVWDP 409 >5HH3-A nrPDB Length = 397 Score = 114 bits (285), Expect = 9e-26, Method: Composition-based stats. Identities = 64/411 (15%), Positives = 120/411 (29%), Gaps = 74/411 (18%) Query: 102 GSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSA 161 G + G + + L + RL + L + E R+R Sbjct: 51 GRTAWLATGYDEIRQVL--SSDDFSARLL---YGGTAAGITWPGFLTQYDPPEHTRLRRM 105 Query: 162 FQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYE 221 + K ++ V+ D L+ ++ L G D WS + + Sbjct: 106 VAPAF-AVRRMQKFQPQVERVVQDSLDAIEAL----GGPVDFVPRFG-WSVATTATCDF- 158 Query: 222 KRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKS 281 G +L + L+ + Sbjct: 159 ---------------------------LGIPRDDQADLARSLHASRTERSGKRRTAAGNK 191 Query: 282 VKPCIDNRLQRYSQQPGADFLCDIYQQ--DHLSKKELYAAVTELQLAAVETTANSLMWIL 339 ++ R + PG D + ++ D ++ EL + A + A L Sbjct: 192 FMTYMNKMTARTRRDPGDDMFGVVVREYGDEITDAELTGVAAFVMGAGADQVARFLAAGA 251 Query: 340 YNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRL-TPSVPFTTRTL 398 + ++ +P+ L ++ +V L E +R T R Sbjct: 252 WLMADDPEQFALLREKPDTV------------------PDWLDEVIRYLTTDEKTHPRVA 293 Query: 399 DKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSH-KFRPERWLQKEKKINPFAHLPFGI 457 +G++ + G +T + NF +F R + HL FG Sbjct: 294 TDDVRIGDHLIKAGDTVTCSLLAANR--RNFPRPEDRFDITRVRPE--------HLAFGH 343 Query: 458 GKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELP 508 G C+GR LAEL A+ + ++ + EP + LG P ++ Sbjct: 344 GIHHCLGRSLAELVFRTAIPALAHRFPTLRLA-EPHREIRLG--PPPFDVE 391 >5OMS-A nrPDB Length = 409 Score = 108 bits (270), Expect = 6e-24, Method: Composition-based stats. Identities = 63/385 (16%), Positives = 126/385 (32%), Gaps = 55/385 (14%) Query: 129 LEIKPWKAYRDHRNEAY-GLMILEGQEWQRVRSAFQKKLMKPVEIMK-LDKKINEVLADF 186 + + R + ++ + G +RS + ++P E+ + +D + + + Sbjct: 63 PDFEAVITPAGGRTFGHPAIIGVNGDIHADLRSMVEPA-LQPAEVDRWIDDLVRPIARRY 121 Query: 187 LERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMM 246 LER + D ++EL E + + GL + ++++ F ++ Sbjct: 122 LERFEN---------DGHAELVAQYCEPVSVRSLGDLLGLQEVDSDKLREWFAKLNRSFT 172 Query: 247 STFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIY 306 + E + N + + A I V P ID ++ P + Sbjct: 173 NAAV------DENGEFANPEGFAEGDQAKAEIRAVVDPLIDKWIEH----PDDSAISHWL 222 Query: 307 QQD-----HLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLP 361 ++ +Y + L A++ + + L L P+ + Sbjct: 223 HDGMPPGQTRDREYIYPTIYVYLLGAMQEPGHGMASTLVGLFSRPEQLEEV--------- 273 Query: 362 DNQTPRAEDLRNMPYLKACLKESMRLTPSVPF-TTRTLDKPTVLGEYALPKGTVLTLNTQ 420 + + + + E +R T + T R KP + LP GT + L+ Sbjct: 274 ---------VDDPTLIPRAIAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTPVMLSYG 324 Query: 421 VLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWII 480 +E ++ R P HL FG G C G A + +AL + Sbjct: 325 SANHDTGKYEAPSQYDLHR--------PPLPHLAFGAGNHACAGIYFANHVMRIALEELF 376 Query: 481 QKYDIVATD-NEPVEMLHLGILVPS 504 + + D E VE G P+ Sbjct: 377 EAIPNLERDTREGVEFWGWGFRGPT 401 >3NV6-A nrPDB Length = 452 Score = 106 bits (265), Expect = 2e-23, Method: Composition-based stats. Identities = 41/238 (17%), Positives = 84/238 (35%), Gaps = 35/238 (14%) Query: 278 IFKSVKPCIDNRLQRYSQQPGADFLCDI----YQQDHLSKKELYAAVTELQLAAVETTAN 333 + V P I R+ G D + + + ++ + ++ L L ++T N Sbjct: 242 FYAYVDPIIRARV----GGDGDDLITLMVNSEINGERIAHDKAQGLISLLLLGGLDTVVN 297 Query: 334 SLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF 393 L + + +L+R+P+ L + ++ +E R P V Sbjct: 298 FLSFFMIHLARHPELVAELRSDPLKLMRGA------------------EEMFRRFPVVSE 339 Query: 394 TTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHL 453 R + K L +G ++ L T + G + + K R +H Sbjct: 340 -ARMVAKDQEYKGVFLKRGDMILLPTALHGLDDAANPEPWKLDFSR--------RSISHS 390 Query: 454 PFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAF 511 FG G C G LA +++ + L +++ + + H GI+ +P+ + Sbjct: 391 TFGGGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGETPIYHSGIVAAVENVPLVW 448 >2IJ7-A nrPDB Length = 396 Score = 105 bits (261), Expect = 7e-23, Method: Composition-based stats. Identities = 48/330 (14%), Positives = 103/330 (31%), Gaps = 53/330 (16%) Query: 170 VEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQK 229 I + + L D + + G DL ++ + + L+ K G+ Q+ Sbjct: 100 KAITPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDF----ADPLATALHCKVLGIPQE 155 Query: 230 ETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKS--VKPCID 287 + + + A + + W I ++ + + Sbjct: 156 DGPKLFRSLSIAFMSSADPIPAAKIN------------WDRDIEYMAGILENPNITTGLM 203 Query: 288 NRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQ 347 L R + P H+S + A V +T + L L +L + PQ Sbjct: 204 GELSRLRKDPA---------YSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQ 254 Query: 348 AQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLT-PSVPFTTRTLDKPTVLGE 406 + L + + A ++E +R+ R +G+ Sbjct: 255 LRNLLHE------------------KPELIPAGVEELLRINLSFADGLPRLATADIQVGD 296 Query: 407 YALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRR 466 + KG ++ + + ++F + +R NP +HL FG G+ C G Sbjct: 297 VLVRKGELVLVLLEGANFDPEHFPNPGSIELDR-------PNPTSHLAFGRGQHFCPGSA 349 Query: 467 LAELQLHLALCWIIQKYDIVATDNEPVEML 496 L + + +++K V +++ Sbjct: 350 LGRRHAQIGIEALLKKMPGVDLAVPIDQLV 379 >4C9K-A nrPDB Length = 421 Score = 102 bits (253), Expect = 5e-22, Method: Composition-based stats. Identities = 47/260 (18%), Positives = 86/260 (33%), Gaps = 35/260 (13%) Query: 259 LHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDI----YQQDHLSKK 314 + ++ A F+ V P I R G D + I + Sbjct: 189 PSGNTPEEQGRSLEAANKGFFEYVAPIIAAR----RGGSGTDLITRILNVEIDGKPMPDD 244 Query: 315 ELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNM 374 V+ L L ++T N L +++ LSR+P+ + +E Sbjct: 245 RALGLVSLLLLGGLDTVVNFLGFMMIYLSRHPETVAEMRREPLK---------------- 288 Query: 375 PYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHK 434 L+ ++E R V R + L +G ++ L T + G + + +D Sbjct: 289 --LQRGVEELFRRFAVV-SDARYVVSDMEFHGTMLKEGDLILLPTALHGLDDRHHDDPMT 345 Query: 435 FRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVE 494 R H F G C G LA L++ + L + + + V Sbjct: 346 VDLSR--------RDVTHSTFAQGPHRCAGMHLARLEVTVMLQEWLARIPEFRLKDRAVP 397 Query: 495 MLHLGILVPSRELPIAFRPR 514 + H GI+ +P+ + P+ Sbjct: 398 IYHSGIVAAVENIPLEWEPQ 417 >6FYJ-A nrPDB Length = 421 Score = 101 bits (252), Expect = 8e-22, Method: Composition-based stats. Identities = 67/408 (16%), Positives = 139/408 (34%), Gaps = 61/408 (14%) Query: 95 QIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQE 154 IF +L ++ +G E Y TE +R + P + + + G+ L+GQ Sbjct: 39 DIFETRLLGKKAICMGGKEAAEIFYDTEKF--KRKDAAPNRVVQTLFGKN-GVQALDGQT 95 Query: 155 WQRVRSAFQKKLMKPVEIMKLDKKIN---EVLADFLERMDELCDERGRIPDLYSELNKWS 211 + R +M P E+ KL E+ D E+MD++ L + + Sbjct: 96 HK-HRKEMFMSIMSPDELEKLTDITKKQWEIAVDKWEQMDKV------------ILYEEA 142 Query: 212 FESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAH 271 E +C E E + M + + + K + + + Sbjct: 143 KEIMCRT---ACQWAGVPVQENEVKRLTKNLGAMFESAAAVGL------KHWLGRHARNY 193 Query: 272 TLAW-DTIFKSVKPCIDNRLQRYSQQPGA---DFLCDIYQQDHLSKKELYAAVTELQLAA 327 W + + V+ N + + + D ++ + + + + +A Sbjct: 194 EEIWIEELIDRVRDGKVNPPENTTLHKFSWYRDLEGNLLDTETAAVE--VINILRPIVA- 250 Query: 328 VETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRL 387 A + +I L P+ + +L + Y + ++E R Sbjct: 251 ---IAIFINFIALALHHYPEEKEKLKS-----------------GDKKYSQMFVQEVRRF 290 Query: 388 TPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKI 447 P PF + K Y +GT+ L+ + +++ F P+R+ + E Sbjct: 291 YPFFPFVVALVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRFAKWEG-- 348 Query: 448 NPFAHLPFGIGK----RMCIGRRLAELQLHLALCWIIQKYDIVATDNE 491 +PF+ +P G G C G + + ++L ++ + D D + Sbjct: 349 SPFSFIPQGGGDYFMGHRCAGEWVTIEVMKVSLDYLTNRMDYEVPDQD 396 >5EX8-A nrPDB Length = 424 Score = 99.0 bits (245), Expect = 4e-21, Method: Composition-based stats. Identities = 55/398 (13%), Positives = 111/398 (27%), Gaps = 71/398 (17%) Query: 102 GSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSA 161 G + G + + L RL + L + E R+R Sbjct: 78 GRTAWLATGIDEVRQVL--GSDKFSARLL---YGGTAAGITWPGFLTQYDPPEHTRLRRM 132 Query: 162 FQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELN-KWSFESICLVLY 220 + K ++ +++ D L+ ++ L G D + + C Sbjct: 133 VVPAFSH-RRMQKFRPRVEQIVQDSLDTIESL----GGPVDFVPHFGWAIATPATC---- 183 Query: 221 EKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFK 280 L +++A +L + L Sbjct: 184 ----DFLGIPRDDQA----------------------DLARILLASRTDRSDKRRTAAGN 217 Query: 281 SVKPCIDNRLQRYSQQPGADFLCDI--YQQDHLSKKELYAAVTELQLAAVETTANSLMWI 338 + + + + G D + D ++ EL + AA + A L Sbjct: 218 KFMTYMKQHVAQSRRGSGDDLFGIVGRENGDAITDAELTGVAAFVMGAAADQVARLLAAG 277 Query: 339 LYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRL-TPSVPFTTRT 397 + + P L ++ ++V L E+MR T R Sbjct: 278 AWLMVEQPAQFALLREKPETV------------------PEWLDETMRYLTTDEKTHPRV 319 Query: 398 LDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGI 457 + +G + G +T + + +F R HL FG Sbjct: 320 ATQDVRIGNQLVKAGDTVTCSLLAANR-PNYPSAEDEFDITR--------EKAEHLAFGH 370 Query: 458 GKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEM 495 G C+GR +AEL +++ + ++ + + E+ Sbjct: 371 GIHHCLGRAMAELMFKVSIPALAHRFPTLRLADPQREI 408 >2RCM-A nrPDB Length = 495 Score = 88.6 bits (218), Expect = 6e-18, Method: Composition-based stats. Identities = 71/495 (14%), Positives = 161/495 (32%), Gaps = 50/495 (10%) Query: 32 ASASRAPKEVPLCPLMTDGETRNVT--SLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEY 89 A + + E P + T ++++ ++PG P++G + + + + + Sbjct: 2 AKKTSSGSETPDLTVATRTGSKDLPIRNIPGNYGLPIVGPIKDRWDYFYDQGAEEFFKSR 61 Query: 90 HKKYGQ-IFRMKLGS-------FDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHR 141 +KY ++R+ + V L L+ + + L + + Sbjct: 62 IRKYNSTVYRVNMPPGAFIAENPQVVALLDGKSFPVLFDVDKVEKKDLLTGTYMPSTELT 121 Query: 142 NEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIP 201 L L+ E + + + ++ + ++ + +++ +G+ Sbjct: 122 GGYRILSYLDPSEPKHEKLKNLLFFLLKSSRNRIFPEFQATYSELFDSLEKELSLKGKA- 180 Query: 202 DLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHK 261 D + +F + Y + + +A IT LH Sbjct: 181 DFGGSSDGTAFNFLARAFYGTN--PADTKLKADAPGLITKWVLF------------NLHP 226 Query: 262 RLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHL--SKKELYAA 319 L+ + + F + + QR + + + D L S++E Sbjct: 227 LLSIGLPRVIEEPLIHTFSLPPALVKSDYQRLYEFFLESAGEILVEADKLGISREEATHN 286 Query: 320 VTELQLAAVETTANSLMWILYNLSRN-----PQAQRRLLQEVQSVLPDNQ-TPRAEDLRN 373 L A T + + N+ + Q RL +E++SV+ N + Sbjct: 287 ---LLFATCFNTWGGMKILFPNMVKRIGRAGHQVHNRLAEEIRSVIKSNGGELTMGAIEK 343 Query: 374 MPYLKACLKESMRLTPSVPFTTRTLDKPTVLGE----YALPKGTVLTLNTQVLGSSEDNF 429 M K+ + E +R P V K V+ + + G +L + F Sbjct: 344 MELTKSVVYECLRFEPPVTAQYGRAKKDLVIESHDAAFKVKAGEMLYGYQPLATRDPKIF 403 Query: 430 EDSHKFRPERWLQKEKKINPFAHLPFGIGK---------RMCIGRRLAELQLHLALCWII 480 + + +F PER++ +E + H+ + G + C G+ L L + I Sbjct: 404 DRADEFVPERFVGEEGE-KLLRHVLWSNGPETETPTVGNKQCAGKDFVVLVARLFVIEIF 462 Query: 481 QKYDIVATDNEPVEM 495 ++YD + + Sbjct: 463 RRYDSFDIEVGTSPL 477 >5M0P-A nrPDB Length = 428 Score = 88.2 bits (217), Expect = 7e-18, Method: Composition-based stats. Identities = 63/417 (15%), Positives = 133/417 (31%), Gaps = 64/417 (15%) Query: 96 IFRMK-LGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQE 154 +F+ K LG V + E Y + QR + P + + + ++G++ Sbjct: 41 VFQTKALGGKPFVVVTGKEGAEMFYNNDVV--QREGMLPKRIVNTLAGKG-AIHTVDGKK 97 Query: 155 WQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFES 214 ++ F + + + E+ + + E+N + Sbjct: 98 HVDRKALFMSLMTEGN-----LNYVRELTRTLWHANTQRMES-------MDEVNIYRESI 145 Query: 215 ICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLA 274 + L R+ +Q E+ T + M+ +F + K K + Sbjct: 146 VLLTKVGTRWAGVQAPPED-IERIATDMDIMIDSFRALG----GAFKGY--KASKEARRR 198 Query: 275 WDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHL-SKKELYAAVTELQLAAVETTAN 333 + + + I+ R G + +D+L + + +L T Sbjct: 199 VEDWLE--EQIIETRKGNIHPPEGTALYEFAHWEDYLGNPMDSRTCAIDLM----NTFRP 252 Query: 334 SL------MWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRL 387 + + L+ ++ NP + ++ E Y +E R Sbjct: 253 LIAINRFVSFGLHAMNENPITREKIKSEPD------------------YAYKFAQEVRRY 294 Query: 388 TPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKI 447 P VPF +P G L L+ E ++D ++FRPER+ + Sbjct: 295 YPFVPFLPGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRPERFETWDG-- 352 Query: 448 NPFAHLPFGIGK----RMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGI 500 +PF +P G G C G + + + ++ + T + P + L + + Sbjct: 353 SPFDLIPQGGGDYWTNHRCAGEWITV----IIMEETMKYFAEKITYDVPEQDLEVDL 405 >2ZQJ-A nrPDB Length = 417 Score = 80.9 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 70/420 (16%), Positives = 142/420 (33%), Gaps = 56/420 (13%) Query: 79 LKKQHDTLAEYHKKY-GQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAY 137 LK+ + + ++Y +F+ +L + + + + Y T+ QR P + Sbjct: 18 LKEGYLFIKNRTERYNSDLFQARLLGKNFICMTGAEAAKVFYDTDRF--QRQNALPKRVQ 75 Query: 138 RDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEV---LADFLERMDELC 194 + + ++G R LM P +L + + E E+ DE+ Sbjct: 76 KSLFGVN-AIQGMDGSA-HIHRKMLFLSLMTPPHQKRLAELMTEEWKAAVTRWEKADEV- 132 Query: 195 DERGRIPDLYSELNKWSFESICLV-LYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMM 253 L + + E +C V Y L + E +E A FI + G Sbjct: 133 -----------VLFEEAKEILCRVACYWAGVPLKETEVKERADDFIDMVD-AFGAVGPRH 180 Query: 254 VTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSK 313 R + A + K+ + + ++Q+ G+ ++ Sbjct: 181 WKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMAFHTQEDGSQL------DSRMAA 234 Query: 314 KELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRN 373 EL V +A + L++ L +P+ + L +++ Sbjct: 235 IELI-NVLRPIVA----ISYFLVFSALALHEHPKYKEWLRS------GNSRER------- 276 Query: 374 MPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSH 433 + ++E R P PF + K V KGT + L+ ++ Sbjct: 277 ----EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPD 332 Query: 434 KFRPERWLQKEKKINPFAHLPFGIGK----RMCIGRRLAELQLHLALCWIIQKYDIVATD 489 +FRPER+ E++ N F +P G G C G + + +L +++ + + + Sbjct: 333 EFRPERF--AEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPE 390 >3DBM-A nrPDB Length = 473 Score = 80.5 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 65/478 (13%), Positives = 150/478 (31%), Gaps = 63/478 (13%) Query: 49 DGETRNVTSLPGPTNWPLLGSL---LEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFD 105 D ++ + +PG P + LE F+ G + ++ + K +FR + Sbjct: 2 DPSSKPLREIPGSYGIPFFQPIKDRLEYFYGTGGRDEYFR-SRMQKYQSTVFRANMPPGP 60 Query: 106 SVHLGSPSLLEAL-------------YRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEG 152 V +P ++ L + + K +R +Y + Sbjct: 61 FVS-SNPKVIVLLDAKSFPILFDVSKVEKKDLFTGTY-MPSTKLTGGYRVLSY--LDPSE 116 Query: 153 QEWQRVRSA--FQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKW 210 ++++ F K I + + E+ + + + + D+ + Sbjct: 117 PRHAQLKNLLFFMLKNSSNRVIPQFETTYTELFEGLEAELAK--NGKAAFNDVGEQ---A 171 Query: 211 SFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQA 270 +F + + E T+ T++S++ + Q Sbjct: 172 AFRFLGRAYFNSN---------PEETKLGTSAPTLISSWV--LFNLAPTLDLGLPWFLQE 220 Query: 271 HTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTEL---QLAA 327 L + + N+L Y Q + + + ++ + + Sbjct: 221 PLLHTFRLPAFLIKSTYNKLYDYFQSVATPVMEQAEKLGVPKDEAVHNILFAVCFNTFGG 280 Query: 328 VETT-ANSLMWILYNLSRNPQAQRRLLQEVQSVLP--DNQTPRAEDLRNMPYLKACLKES 384 V+ N+L WI N Q L +E++ + + E + MP K+ + ES Sbjct: 281 VKILFPNTLKWIGLA-GENLHTQ--LAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVVYES 337 Query: 385 MRLTPSVPFTTRTLDKPTVL----GEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERW 440 +R+ P VP + + + KG +L F+ ++ P+R+ Sbjct: 338 LRIEPPVPPQYGKAKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRF 397 Query: 441 LQKEKKINPFAHLPFGIGK---------RMCIGRRLAELQLHLALCWIIQKYDIVATD 489 + + + + + G + C G+ L L + + ++YD + Sbjct: 398 VGDGEALLKYVW--WSNGPETESPTVENKQCAGKDFVVLITRLFVIELFRRYDSFEIE 453 >5YHJ-A nrPDB Length = 413 Score = 79.8 bits (195), Expect = 3e-15, Method: Composition-based stats. Identities = 72/411 (17%), Positives = 129/411 (31%), Gaps = 57/411 (13%) Query: 96 IFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEW 155 IF +L + LG E Y + R + P + + E G+ L+G E Sbjct: 36 IFESRLLGERVICLGGEEAAEVFYD-ANKFT-RQDAAPKRLLKTLFGEG-GVQTLDGSE- 91 Query: 156 QRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDL-YSELNKWSFES 214 R LM I +L + E E + D+ L K E Sbjct: 92 HTHRKQMFMSLMTKENIDRLLRLTYREWNQI-----ERMGEEIVLYDIAQEVLMKAVCEW 146 Query: 215 ICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLA 274 + L ++ G +E ++ + + + T L + ++ Sbjct: 147 SGVPLAKEEVGKRTEE-----------MRLLFESGTSLGPT------YLQGRKARSSAEV 189 Query: 275 WDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANS 334 W I + VK NRL +F + L +E+ A L + Sbjct: 190 W--IRQMVKEVRSNRLLPNEHTALYEFSWHRDESGELLPEEVVAVEVLNILRPTVAISVY 247 Query: 335 LMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFT 394 +++ + L + P + ++ E V ++E R P P Sbjct: 248 VLFTVLALHQFPDVKEQV--ERGEVSKTE----------------FVQEVRRFYPFFPVA 289 Query: 395 TRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLP 454 + YA P+GT+ L+ + + +F P R+ K+ K +PF +P Sbjct: 290 AARVKTDFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSRF--KDWKESPFNFIP 347 Query: 455 FGIGK----RMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGIL 501 G G C G + L +I+ + P + L + Sbjct: 348 QGGGDVDFGHRCAGEHVTIA----ILAQVIELFTKEYAYTVPPQDLSYSFV 394 >3AWQ-A nrPDB Length = 415 Score = 78.2 bits (191), Expect = 9e-15, Method: Composition-based stats. Identities = 23/125 (18%), Positives = 44/125 (35%), Gaps = 6/125 (4%) Query: 371 LRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFE 430 ++ Y + ++E R P P + A P+G + L+ + Sbjct: 268 VQQPDYAELFVQEVRRFYPFFPAVVARASQDFEWEGMAFPEGRQVVLDLYGSNHDAATWA 327 Query: 431 DSHKFRPERWLQKEKKINPFAHLPFGIGK----RMCIGRRLAELQLHLALCWIIQKYDIV 486 D +FRPER+ + + F +P G G C G + + +A ++ Sbjct: 328 DPQEFRPERF--RAWDEDSFNFIPQGGGDHYLGHRCPGEWIVLAIMKVAAHLLVNAMRYD 385 Query: 487 ATDNE 491 D + Sbjct: 386 VPDQD 390 >2YJN-B nrPDB Length = 381 Score = 64.7 bits (156), Expect = 8e-11, Method: Composition-based stats. Identities = 21/133 (15%), Positives = 43/133 (32%), Gaps = 18/133 (13%) Query: 320 VTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKA 379 A E TAN+++ + +S P R+ + + + Sbjct: 216 ALRALFAGAEMTANTVVDAVLAVSAEPGLAERIADDPAAA------------------QR 257 Query: 380 CLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPER 439 + E +RL P++ RT LGE+ + +G + + + F + + +R Sbjct: 258 TVAEVLRLHPALHLERRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVDR 317 Query: 440 WLQKEKKINPFAH 452 H Sbjct: 318 PDADRALSAHRGH 330 >3KY9-A nrPDB Length = 587 Score = 32.4 bits (72), Expect = 0.44, Method: Composition-based stats. Identities = 15/101 (14%), Positives = 41/101 (40%), Gaps = 10/101 (9%) Query: 222 KRFGLLQKETEEEALTF-ITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFK 280 ++FGL + E E F + ++ T + TP+ ++ + + ++ + I+ Sbjct: 87 EKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYS 146 Query: 281 SVKPCIDNRLQRY---------SQQPGADFLCDIYQQDHLS 312 + ID+ ++ + G + D+ + + +S Sbjct: 147 GLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVS 187 >4H3S-A nrPDB Length = 817 Score = 31.2 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 46/332 (13%), Positives = 96/332 (28%), Gaps = 53/332 (15%) Query: 8 RRTLI--AFLRRLRDLGQPPRSVTSKASASRAPKEVPLCPLMTDGETRNVTSLPGPTNWP 65 +RT+ FL L +G+ P++ P+ + +T G+ R P P + Sbjct: 215 KRTMFNEGFLGDLHKVGENPQAY---------PELMKEHLEVTGGKVRT-RFPPEPNGYL 264 Query: 66 LLGSLLEIFWKGGLKKQHDTLAEYH-------KKYGQIFR------MKLGSFDSVHLGSP 112 +G I G K H+ K+ + F LG S Sbjct: 265 HIGHSKAIMVNFGYAKYHNGTCYLRFDDTNPEKEAPEYFESIKRMVSWLGFKPWKITYSS 324 Query: 113 SLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLM---ILEGQEWQRVRSAFQKKL--- 166 + LYR + + + G+ G+ + + Sbjct: 325 DYFDELYRLAEVLIKNGKAYVCHCTAEEIKRGRGIKEDGTPGGERYACKHRDQSIEQNLQ 384 Query: 167 ----MKP------VEIMKLDKKINEVLADFLERMDELCDERGRIPD-------LYSELNK 209 M+ I+++ + +N + + + Sbjct: 385 EFRDMRDGKYKPGEAILRMKQDLNSPSPQMWDLIAYRVLNAPHPRTGTKWRIYPTYDFTH 444 Query: 210 WSFESICLVLYEKRFG--LLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKV 267 +S+ + + L +E+ E + + +G++ +T L KR K+ Sbjct: 445 CLVDSMENITHSLCTTEFYLSRESYEWLCDQVHVFRPAQREYGRLNITGTVLSKR---KI 501 Query: 268 WQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGA 299 Q + + + ++R PGA Sbjct: 502 AQLVDEKFVRGWDDPRLFTLEAIRRRGVPPGA 533 >1LQA-A nrPDB Length = 346 Score = 29.7 bits (65), Expect = 3.0, Method: Composition-based stats. Identities = 6/39 (15%), Positives = 14/39 (35%) Query: 73 IFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGS 111 + K + HD+L Y ++++ + G Sbjct: 105 LDRKNIREALHDSLKRLQTDYLDLYQVHWPQRPTNCFGK 143 >3HGT-A nrPDB Length = 328 Score = 29.3 bits (64), Expect = 4.3, Method: Composition-based stats. Identities = 17/121 (14%), Positives = 40/121 (33%), Gaps = 2/121 (1%) Query: 182 VLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITA 241 VL D + + E E + ++ + ++ KR+ ++ A F Sbjct: 113 VLRDLINLVQEYETETAIVCRPGRTMDLLEALLLGNKVHIKRYDGHSIKSAAAANDFSCT 172 Query: 242 IKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADF 301 + S P++ R + + DT K ++ + + +R + A Sbjct: 173 VHLFSSEGINFTKYPIKSKARFDMLICLD--TTVDTSQKDIQYLLQYKRERKGLERYAPI 230 Query: 302 L 302 + Sbjct: 231 V 231 >3RP9-A nrPDB Length = 458 Score = 29.3 bits (64), Expect = 4.4, Method: Composition-based stats. Identities = 12/61 (19%), Positives = 23/61 (37%), Gaps = 3/61 (4%) Query: 343 SRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMP---YLKACLKESMRLTPSVPFTTRTLD 399 +P + + EV++ + D NM A +KE R P + R+ + Sbjct: 395 LAHPFFKEVRIAEVETNATEKVRLPFNDWMNMDEPQLRYAFVKEIQRYHPEIQLPRRSPN 454 Query: 400 K 400 + Sbjct: 455 R 455 >3G6B-A nrPDB Length = 213 Score = 28.9 bits (63), Expect = 4.8, Method: Composition-based stats. Identities = 15/81 (18%), Positives = 32/81 (39%), Gaps = 9/81 (11%) Query: 304 DIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDN 363 +I + S + L ET +L ++ + + +LLQEV++ L + Sbjct: 141 EILESSQRSLENLEFMANLF-----ETVGKTLQNMVRFM----ENIVKLLQEVRNSLDTS 191 Query: 364 QTPRAEDLRNMPYLKACLKES 384 + +E + L+E+ Sbjct: 192 KESLSEKSAEIDSATKVLEET 212 >5XF8-3 nrPDB Length = 997 Score = 28.9 bits (63), Expect = 5.0, Method: Composition-based stats. Identities = 20/143 (13%), Positives = 42/143 (29%), Gaps = 17/143 (11%) Query: 286 IDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRN 345 I N + ++ D L + A+ + + VE +N Sbjct: 373 IRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVE--------------KN 418 Query: 346 PQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKA--CLKESMRLTPSVPFTTRTLDKPTV 403 + L ++ ++ + + L A + + R S T + Sbjct: 419 LENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGR-GSSGVGLTAAVTTDRE 477 Query: 404 LGEYALPKGTVLTLNTQVLGSSE 426 GE L G ++ + V+ E Sbjct: 478 TGERRLEAGAMVLADRGVVCIDE 500 >2TMD-A nrPDB Length = 729 Score = 28.9 bits (63), Expect = 5.2, Method: Composition-based stats. Identities = 14/50 (28%), Positives = 18/50 (36%), Gaps = 3/50 (6%) Query: 323 LQLAAVETTANS---LMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAE 369 L A E T S L ++ P RRL + L D+ R E Sbjct: 549 LATAGHEVTIVSGVHLANYMHFTLEYPNMMRRLHELHVEELGDHFCSRIE 598 >4DJD-D nrPDB Length = 323 Score = 28.5 bits (62), Expect = 6.5, Method: Composition-based stats. Identities = 9/45 (20%), Positives = 16/45 (35%), Gaps = 10/45 (22%) Query: 319 AVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDN 363 T L A L R+P+A R+ + + ++ N Sbjct: 287 TATALLQAGAH----------ILLMRHPEAVARVKENIDQLMVSN 321 >6CY1-A nrPDB Length = 329 Score = 28.5 bits (62), Expect = 7.5, Method: Composition-based stats. Identities = 19/105 (18%), Positives = 38/105 (36%), Gaps = 10/105 (9%) Query: 287 DNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLA---AVETTANSLMWILYNLS 343 ++ S Q D + E+ + E+ +A VETT + I ++ Sbjct: 25 LDKGLEKSSQSFFDKVSRAVVGKSKVDDEVLDDLEEVLIASDVGVETTVKIIRRIEERVA 84 Query: 344 RNP-----QAQRRLLQEVQSVLPDNQTPRAE--DLRNMPYLKACL 381 R+ + L +E+ +L +N + D PY+ + Sbjct: 85 RDKYVNVAELNNILREEISGLLLENPHAGTQNIDKTKKPYVIMVV 129 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.131 0.351 Lambda K H 0.267 0.0405 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,719,843 Number of Sequences: 36641 Number of extensions: 741481 Number of successful extensions: 3075 Number of sequences better than 10.0: 182 Number of HSP's better than 10.0 without gapping: 277 Number of HSP's successfully gapped in prelim test: 56 Number of HSP's that attempted gapping in prelim test: 2066 Number of HSP's gapped (non-prelim): 370 length of query: 514 length of database: 10,336,785 effective HSP length: 101 effective length of query: 413 effective length of database: 6,636,044 effective search space: 2740686172 effective search space used: 2740686172 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 61 (28.1 bits)