BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q08257 (329 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1YB5-A nrPDB 669 0.0 4A27-A nrPDB 157 6e-39 1QOR-A nrPDB 140 7e-34 5K1S-A nrPDB 134 5e-32 4RVS-A nrPDB 132 1e-31 3JYN-A nrPDB 117 8e-27 2OBY-A nrPDB 111 4e-25 3UOG-A nrPDB 107 8e-24 1WLY-A nrPDB 107 8e-24 4J6F-A nrPDB 107 9e-24 3SLK-A nrPDB 105 3e-23 3FBG-A nrPDB 105 3e-23 2EER-A nrPDB 105 4e-23 4EYE-A nrPDB 104 4e-23 3TQH-A nrPDB 102 2e-22 3PII-A nrPDB 102 3e-22 5A3V-A nrPDB 100 2e-21 1LLU-A nrPDB 97 1e-20 4DVJ-A nrPDB 96 3e-20 2VN8-A nrPDB 94 6e-20 3QWB-A nrPDB 92 4e-19 1R37-A nrPDB 92 5e-19 3S2F-A nrPDB 90 1e-18 4IDE-A nrPDB 87 1e-17 3MEQ-A nrPDB 80 1e-15 1V3V-A nrPDB 80 1e-15 4Z6K-A nrPDB 79 3e-15 3HZZ-A nrPDB 78 5e-15 2VCY-A nrPDB 76 2e-14 5ENV-A nrPDB 73 2e-13 6N7L-A nrPDB 72 3e-13 4EJ6-A nrPDB 72 4e-13 5VM2-A nrPDB 71 6e-13 4A10-A nrPDB 69 4e-12 3B70-A nrPDB 68 5e-12 2WEK-A nrPDB 67 8e-12 4EEZ-A nrPDB 66 2e-11 2Y05-A nrPDB 64 9e-11 2J3K-A nrPDB 64 1e-10 5TNX-A nrPDB 63 2e-10 2DQ4-A nrPDB 62 2e-10 4Y1B-A nrPDB 62 2e-10 1H2B-A nrPDB 62 3e-10 5GXF-A nrPDB 61 8e-10 1O89-A nrPDB 58 7e-09 4CPD-A nrPDB 57 7e-09 4OH1-A nrPDB 57 9e-09 2DFV-A nrPDB 57 2e-08 1PL8-A nrPDB 55 6e-08 5YAT-A nrPDB 55 6e-08 1HSO-A nrPDB 54 1e-07 1HSZ-A nrPDB 53 2e-07 2H6E-A nrPDB 52 5e-07 1U3W-A nrPDB 52 5e-07 1MC5-A nrPDB 51 6e-07 5LB9-A nrPDB 51 7e-07 1E3E-A nrPDB 50 1e-06 4ILK-A nrPDB 50 1e-06 4OAQ-A nrPDB 50 1e-06 5H82-A nrPDB 50 1e-06 3GFB-A nrPDB 49 2e-06 1F8F-A nrPDB 49 3e-06 1E3J-A nrPDB 49 4e-06 3QE3-A nrPDB 48 5e-06 1P0F-A nrPDB 48 6e-06 4UEJ-A nrPDB 47 1e-05 1EE2-A nrPDB 47 1e-05 1D1T-A nrPDB 46 2e-05 5YLN-A nrPDB 44 8e-05 3WLE-A nrPDB 42 5e-04 4RQU-A nrPDB 40 0.002 5VKT-A nrPDB 39 0.004 4JJI-A nrPDB 39 0.004 4DLA-A nrPDB 38 0.006 4GKV-A nrPDB 38 0.007 5Z0C-A nrPDB 37 0.009 5FI5-A nrPDB 37 0.010 3RSH-A nrPDB 37 0.015 3COS-A nrPDB 36 0.027 1Q1N-A nrPDB 36 0.027 1Q7C-A nrPDB 35 0.047 1CDO-A nrPDB 35 0.050 4M8S-A nrPDB 34 0.069 1YQX-A nrPDB 33 0.17 3TWO-A nrPDB 33 0.18 6C49-A nrPDB 32 0.30 6FG0-A nrPDB 32 0.39 2ISQ-A nrPDB 31 0.58 5CDY-A nrPDB 31 0.66 1UUF-A nrPDB 30 1.2 1EBD-A nrPDB 30 1.9 3WD7-A nrPDB 29 2.4 5H83-A nrPDB 29 3.5 6DUE-A nrPDB 28 4.6 3JC6-4 nrPDB 28 5.5 3BZK-A nrPDB 28 7.0 1NEE-A nrPDB 27 8.7 3SFT-A nrPDB 27 8.9 >1YB5-A nrPDB Length = 351 Score = 669 bits (1725), Expect = 0.0, Method: Compositional matrix adjust. Identities = 329/329 (100%), Positives = 329/329 (100%) Query: 1 MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS 60 MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS Sbjct: 23 MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS 82 Query: 61 RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEK 120 RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEK Sbjct: 83 RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEK 142 Query: 121 LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA 180 LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA Sbjct: 143 LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA 202 Query: 181 GTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG 240 GTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG Sbjct: 203 GTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG 262 Query: 241 GRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG 300 GRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG Sbjct: 263 GRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG 322 Query: 301 SQYPLEKVAEAHENIIHGSGATGKMILLL 329 SQYPLEKVAEAHENIIHGSGATGKMILLL Sbjct: 323 SQYPLEKVAEAHENIIHGSGATGKMILLL 351 >4A27-A nrPDB Length = 349 Score = 157 bits (397), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 113/347 (32%), Positives = 175/347 (50%), Gaps = 37/347 (10%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67 MRAV + FGG L+L A+P P+D ++ I+V ACG+N ++ +R G P P Sbjct: 4 MRAVVLAGFGGLNKLRLFRK-AMPEPQDGELKIRVKACGLNFIDLMVRQGNIDNPPKTPL 62 Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQGA 127 PG + +G++EA+GD+ ++ GDRV + +AE VYK+P+ + F + A Sbjct: 63 VPGFECSGIVEALGDSVKGYEIGDRVMAFVNYN-AWAEVVCTPVEFVYKIPDDMSFSEAA 121 Query: 128 AIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAY-GLKILGTAGTEEGQ 186 A + + TAY L A ++ G SVLVH A GGVG A Q+ + + GTA T + + Sbjct: 122 AFPMNFVTAYVMLFEVANLREGMSVLVHSAGGGVGQAVAQLCSTVPNVTVFGTASTFKHE 181 Query: 187 KIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVV 246 I ++ +F+ R +Y+ ++K+ E G+DI+++ L N K LSLL G I+ Sbjct: 182 AI--KDSVTHLFD-RNADYVQEVKRISAE-GVDIVLDCLCGDNTGKGLSLLKPLGTYILY 237 Query: 247 GSRGTI------------------EINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQA 288 GS + ++NP + I G +L + F+Q A L Sbjct: 238 GSSNMVTGETKSFFSFAKSWWQVEKVNPIKLYEENKVIAGFSLLNLL---FKQGRAGLIR 294 Query: 289 GME---IGW-----LKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 G+ IG +KPV+ S + LE+V EA + IH G GK+IL Sbjct: 295 GVVEKLIGLYNQKKIKPVVDSLWALEEVKEAMQR-IHDRGNIGKLIL 340 >1QOR-A nrPDB Length = 327 Score = 140 bits (353), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 99/329 (30%), Positives = 168/329 (51%), Gaps = 18/329 (5%) Query: 11 VRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPG 70 + + GGPEVL+ + P ++++ ++ A G+N ++TYIRSG Y P LP G Sbjct: 5 IEFHKHGGPEVLQA-VEFTPADPAENEIQVENKAIGINFIDTYIRSGLYP-PPSLPSGLG 62 Query: 71 SDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAE-YALAADHTVYKLPEKLDFKQGAAI 129 ++ AG++ VG K GDRV + + G Y+ + + AD LP + F+Q AA Sbjct: 63 TEAAGIVSKVGSGVKHIKAGDRVVYAQSALGAYSSVHNIIADKAAI-LPAAISFEQAAAS 121 Query: 130 GIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIV 189 + T Y L + +K E L H A+GGVGL ACQ A+A G K++GT GT + + Sbjct: 122 FLKGLTVYYLLRKTYEIKPDEQFLFHAAAGGVGLIACQWAKALGAKLIGTVGTAQKAQSA 181 Query: 190 LQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVG-S 248 L+ GA +V N+RE + ++++K+ G K + ++ + + + L L G ++ G S Sbjct: 182 LKAGAWQVINYREEDLVERLKEITGGKKVRVVYDSVGRDTWERSLDCLQRRGLMVSFGNS 241 Query: 249 RGTIE------INPRDTM-AKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGS 301 G + +N + ++ S+ G + +T+EE + + L + + G +K + Sbjct: 242 SGAVTGVNLGILNQKGSLYVTRPSLQG---YITTREELTEASNELFSLIASGVIKVDVAE 298 Query: 302 Q--YPLEKVAEAHENIIHGSGATGKMILL 328 Q YPL+ AHE I+ G +L+ Sbjct: 299 QQKYPLKDAQRAHE-ILESRATQGSSLLI 326 >5K1S-A nrPDB Length = 362 Score = 134 bits (337), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 97/337 (28%), Positives = 167/337 (49%), Gaps = 37/337 (10%) Query: 5 QKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPL 64 Q M+AV + FG LK+ + + +P P +VL++VHACGV + R G R + Sbjct: 15 QGHMKAVVLRSFGEAGNLKMET-MPMPRPGRGEVLLRVHACGVCYHDVINRRGNLPRTSV 73 Query: 65 LPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTIS------------------------ 100 P G + AG + VG + +K GDR T +S Sbjct: 74 -PAILGHEAAGEVIEVGPDTPGWKTGDRAATLQRMSCGDCALCRSGRNSLCKTDNRFFGE 132 Query: 101 ---GGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGA 157 GGYA++ +A + ++P L + + A + TA + V+AGE+VL+ GA Sbjct: 133 ELPGGYAQFMVAPVGGLGRVPASLPWNEAATVCCTTGTAVHTVRTRGKVRAGETVLITGA 192 Query: 158 SGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKG 217 SGGVGL++ Q+AR G +++ +E + + + GA EV R +++ ++K G Sbjct: 193 SGGVGLSSVQLARLDGARVIAVTSSEAKVQALKEAGADEVIVSRGLDFASDVRKRTQGAG 252 Query: 218 IDIIIEMLANVNLSKDLSLLSHGGRVIVVGS--RGTIEINPRDTMAKESSIIGVTLFSST 275 +D+ +E++ + + L ++ GGRV+VVG+ G +++NP + KE I+G +++T Sbjct: 253 VDVAVEIVGSATFDQTLKSMAPGGRVVVVGNLESGMVQLNPGLVIVKELEILGA--YATT 310 Query: 276 KEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAH 312 + E + A L A G ++ + PL + A+AH Sbjct: 311 QAELDE-ALRLTA---TGGVRQFVTDAVPLAEAAKAH 343 >4RVS-A nrPDB Length = 329 Score = 132 bits (333), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 103/332 (31%), Positives = 165/332 (49%), Gaps = 16/332 (4%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67 M A+ V E GGP VL+ D P P ++LIK A GVN ++TY RSG Y R+ LP+ Sbjct: 2 MHAIEVTETGGPGVLR-HVDQPQPQPGHGELLIKAEAIGVNFIDTYFRSGQYPRE--LPF 58 Query: 68 TPGSDVAGVIEAVGDNASA----FKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDF 123 GS+V G +EAVG +A GDRV ++S +G YAE+ A K+P+ + Sbjct: 59 VIGSEVCGTVEAVGPGVTAADTAISVGDRVVSASA-NGAYAEFCTAPASLTAKVPDDVTS 117 Query: 124 KQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTE 183 + A+ + TA+ L VK G++VLVH +GGVGL Q A G++++ T T Sbjct: 118 EVAASALLKGLTAHYLLKSVYPVKRGDTVLVHAGAGGVGLILTQWATHLGVRVITTVSTA 177 Query: 184 EGQKIVLQNGAHEVFNHRE--VNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGG 241 E K+ GA V ++ E + ++++ G G+ + + + L+ L+ G Sbjct: 178 EKAKLSKDAGADVVLDYPEDAWQFAGRVRELTGGTGVQAVYDGVGATTFDASLASLAVRG 237 Query: 242 RVIVVG-SRGTI-EINPRDTMAKESSII---GVTLFSSTKEEFQQYAAALQAGMEIGWLK 296 + + G + G + ++P+ A S + + F+ T EEF AA L + + Sbjct: 238 TLALFGAASGPVPPVDPQRLNAAGSVYLTRPSLFHFTRTGEEFSWRAAELFDAIGNEAIT 297 Query: 297 PVIGSQYPLEKVAEAHENIIHGSGATGKMILL 328 +G +YPL AH++ + G ++LL Sbjct: 298 VAVGGRYPLADALRAHQD-LEARKTVGSVVLL 328 >3JYN-A nrPDB Length = 325 Score = 117 bits (292), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 96/327 (29%), Positives = 156/327 (47%), Gaps = 8/327 (2%) Query: 7 LMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLP 66 + + ++ GGPEVL+ D P V+++ A G+N ++TY RSG Y P LP Sbjct: 1 MAKRIQFSTVGGPEVLEY-VDFEPEAPGPQAVVVRNKAIGLNFIDTYYRSGLYP-APFLP 58 Query: 67 YTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQG 126 G++ AGV+EAVGD + FK GDRV + G Y+E + + + KL + + F+Q Sbjct: 59 SGLGAEGAGVVEAVGDEVTRFKVGDRVAYGTGPLGAYSEVHVLPEANLVKLADSVSFEQA 118 Query: 127 AAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQ 186 AA+ + T L + VK GE +L H A+GGVG ACQ A+A G K++GT + E Sbjct: 119 AALMLKGLTVQYLLRQTYQVKPGEIILFHAAAGGVGSLACQWAKALGAKLIGTVSSPEKA 178 Query: 187 KIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVV 246 GA E ++ + ++ + K ++ + + L ++ G V+ Sbjct: 179 AHAKALGAWETIDYSHEDVAKRVLELTDGKKCPVVYDGVGQDTWLTSLDSVAPRGLVVSF 238 Query: 247 G-SRGTIEINPRDTMAKESSIIGV--TL--FSSTKEEFQQYAAALQAGMEIGWLKPVIGS 301 G + G + +A++ S+ TL +++ + Q A L + G LK Sbjct: 239 GNASGPVSGVNLGILAQKDSVYVTRPTLGSYANNAQNLQTMADELFDMLASGKLKVDGIE 298 Query: 302 QYPLEKVAEAHENIIHGSGATGKMILL 328 QY L+ A+A + TG IL+ Sbjct: 299 QYALKDAAKAQIE-LSARRTTGSTILI 324 >2OBY-A nrPDB Length = 338 Score = 111 bits (278), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 92/332 (27%), Positives = 158/332 (47%), Gaps = 12/332 (3%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67 M AV + GGPE L ++ ++A P P + +VL+KV A +N + R G Y P Sbjct: 7 MLAVHFDKPGGPENLYVK-EVAKPSPGEGEVLLKVAASALNRADLMQRQGQYDPPPGASN 65 Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQGA 127 G + +G + +G K + GG A+Y + + +PE L Q A Sbjct: 66 ILGLEASGHVAELGPGCQGHWKIGDTAMALLPGGGQAQYVTVPEGLLMPIPEGLTLTQAA 125 Query: 128 AIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQK 187 AI + TA++ L V+AG+ VL+H GVG AA Q+ R G L TAG+++ + Sbjct: 126 AIPEAWLTAFQLLHLVGNVQAGDYVLIHAGLSGVGTAAIQLTRMAGAIPLVTAGSQKKLQ 185 Query: 188 IVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVG 247 + + GA FN+++ ++ + K+ G+++I++ + K+++ L+ GR ++ G Sbjct: 186 MAEKLGAAAGFNYKKEDFSEATLKFTKGAGVNLILDCIGGSYWEKNVNCLALDGRWVLYG 245 Query: 248 SRGTIEIN-P--RDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGW-------LKP 297 G +IN P + K S+I L S + Q A + + L P Sbjct: 246 LMGGGDINGPLFSKLLFKRGSLITSLLRSRDNKYKQMLVNAFTEQILPHFSTEGPQRLLP 305 Query: 298 VIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 V+ YP+ ++ EAH+ + + GK++L L Sbjct: 306 VLDRIYPVTEIQEAHK-YMEANKNIGKIVLEL 336 >3UOG-A nrPDB Length = 363 Score = 107 bits (267), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 82/325 (25%), Positives = 155/325 (47%), Gaps = 33/325 (10%) Query: 19 PEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIE 78 P LKL ++ VP +H ++++ A +N + + P+ P SD++GV+E Sbjct: 38 PHDLKL-AERPVPEAGEHDIIVRTLAVSLNYRDKLVLETGMGLDLAFPFVPASDMSGVVE 96 Query: 79 AVGDNASAFKKGDRVFTS-------------------STISGGY----AEYALAADHTVY 115 AVG + + F+ GDRV ++ T+ G + +EY + + Sbjct: 97 AVGKSVTRFRPGDRVISTFAPGWLDGLRPGTGRTPAYETLGGAHPGVLSEYVVLPEGWFV 156 Query: 116 KLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLK 175 P+ LD + + + TA+ AL+ ++AG+ V+V G +GGV L QIA+A G + Sbjct: 157 AAPKSLDAAEASTLPCAGLTAWFALVEKGHLRAGDRVVVQG-TGGVALFGLQIAKATGAE 215 Query: 176 ILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLS 235 ++ T+ + E GA N E ++++++ G++G D I+E+ L + L Sbjct: 216 VIVTSSSREKLDRAFALGADHGINRLEEDWVERVYALTGDRGADHILEIAGGAGLGQSLK 275 Query: 236 LLSHGGRVIVVGSRGTIEIN-PRDTMAKESSII-GVTLFSSTKEEFQQYAAALQAGMEIG 293 ++ GR+ V+G E++ P + +S ++ G+++ + + A+ +G Sbjct: 276 AVAPDGRISVIGVLEGFEVSGPVGPLLLKSPVVQGISV--GHRRALEDLVGAVD---RLG 330 Query: 294 WLKPVIGSQYPLEKVAEAHENIIHG 318 LKPVI +Y +V EA ++ G Sbjct: 331 -LKPVIDMRYKFTEVPEALAHLDRG 354 >1WLY-A nrPDB Length = 333 Score = 107 bits (266), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 90/334 (26%), Positives = 152/334 (45%), Gaps = 16/334 (4%) Query: 7 LMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLL- 65 ++ A + + GGP+ + ++ V P QV ++ A GVN ++TY R+G PL+ Sbjct: 1 MVMAAVIHKKGGPDNF-VWEEVKVGSPGPGQVRLRNTAIGVNFLDTYHRAGI--PHPLVV 57 Query: 66 ---PYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLD 122 P G + A V+E VG + F G+RV T G Y++ L + K+P+ LD Sbjct: 58 GEPPIVVGFEAAAVVEEVGPGVTDFTVGERVCTCLPPLGAYSQERLYPAEKLIKVPKDLD 117 Query: 123 FK--QGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA 180 A + + TA L + VK G+ VL+H A+GG+G AR G ++GT Sbjct: 118 LDDVHLAGLMLKGMTAQYLLHQTHKVKPGDYVLIHAAAGGMGHIMVPWARHLGATVIGTV 177 Query: 181 GTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG 240 TEE + + G H N+ ++ + +++ G KG+D++ + + L K L L Sbjct: 178 STEEKAETARKLGCHHTINYSTQDFAEVVREITGGKGVDVVYDSIGKDTLQKSLDCLRPR 237 Query: 241 GRVIVVGSRGTIEINPR---DTMAKESSII---GVTLFSSTKEEFQQYAAALQAGMEIGW 294 G G + R D + S I + + S + E + + L ++ G Sbjct: 238 GMCAAYGHASGVADPIRVVEDLGVRGSLFITRPALWHYMSNRSEIDEGSKCLFDAVKAGV 297 Query: 295 LKPVIGSQYPLEKVAEAHENIIHGSGATGKMILL 328 L + +PL + A AH+ + G G ++LL Sbjct: 298 LHSSVAKTFPLREAAAAHK-YMGGRQTIGSIVLL 330 >4J6F-A nrPDB Length = 382 Score = 107 bits (266), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 95/358 (26%), Positives = 158/358 (44%), Gaps = 44/358 (12%) Query: 6 KLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKP-- 63 K M AV + GG E L D+ VP P +VLIKV ACG+N + ++R G Y + Sbjct: 32 KTMTAVLLTGHGGLEKLVYSRDVPVPAPAAGEVLIKVTACGMNNTDVWVREGAYGTEDDP 91 Query: 64 -------------LLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTI----------- 99 P G+D G I AVG+ + G+RV +I Sbjct: 92 SAVSTWRRHGNTLTFPRIQGTDTVGHIVAVGEGVDRARIGERVMVDFSIYNRDDDSLADI 151 Query: 100 -------SGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESV 152 GGYAEY + + L + A Y T R ++ A + AGE+V Sbjct: 152 DYMGHGRDGGYAEYMALPAENAHVVATDLTDIELATFCCAYLTGER-MLERARLAAGETV 210 Query: 153 LVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKY 212 LV GASGGVG A Q+ARA G + AG + + +L GA V + + + ++ Sbjct: 211 LVTGASGGVGSAIIQLARARGAVPIAVAGPGK-EAAMLDIGAQAVVTRGQGDLAEAVEAA 269 Query: 213 VGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRG--TIEINPRDTMAKESSIIGVT 270 G + ID++ +++ + L +L GR G+ ++++ R K+ + G + Sbjct: 270 SGGRPIDVVADLVGGPLFNDLLKILRPEGRYTTAGAIAGPVVQLDLRTMYLKQLELHGSS 329 Query: 271 LFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILL 328 ++ +F++ L +E ++P++G YPL + A + + GK++++ Sbjct: 330 --QGSRADFRR----LVRYIEEKKIRPLVGGVYPLSEFHRAQTDFM-AKNFVGKLVVV 380 >3SLK-A nrPDB Length = 795 Score = 105 bits (262), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 70/223 (31%), Positives = 111/223 (49%), Gaps = 11/223 (4%) Query: 35 DHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVF 94 D +V I + A GVN + I G Y L GS+ AGV+ G + GDRV Sbjct: 238 DGEVRIAMRAAGVNFRDALIALGMYPGVASL----GSEGAGVVVETGPGVTGLAPGDRVM 293 Query: 95 TSSTISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLV 154 I + A+A V ++P F + A++ I + TAY AL+ A ++ GES+LV Sbjct: 294 --GMIPKAFGPLAVADHRMVTRIPAGWSFARAASVPIVFLTAYYALVDLAGLRPGESLLV 351 Query: 155 HGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVG 214 H A+GGVG+AA Q+AR G ++ TA ++ Q + L + + R ++ + G Sbjct: 352 HSAAGGVGMAAIQLARHLGAEVYATASEDKWQAVELSR--EHLASSRTCDFEQQFLGATG 409 Query: 215 EKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGS---RGTIEI 254 +G+D+++ LA L +L GGR + +G R +E+ Sbjct: 410 GRGVDVVLNSLAGEFADASLRMLPRGGRFLELGKTDVRDPVEV 452 >3FBG-A nrPDB Length = 346 Score = 105 bits (261), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 62/184 (33%), Positives = 101/184 (54%), Gaps = 11/184 (5%) Query: 27 DIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASA 86 ++ +P PK H++L+K+ + VNPV+T R S+ P + G D GV+E+VG+ + Sbjct: 24 NLDIPEPKVHEILVKIQSISVNPVDTKQRLMDVSKAPRVL---GFDAIGVVESVGNEVTM 80 Query: 87 FKKGDRVFTSST--ISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALI--- 141 F +GD V+ S + +G AEY L + V K P+ + +Q ++ + TAY L Sbjct: 81 FNQGDIVYYSGSPDQNGSNAEYQLINERLVAKAPKNISAEQAVSLPLTGITAYETLFDVF 140 Query: 142 ---HSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVF 198 + G+++L+ +GGVG A QIA+AYGL+++ TA E + + GA V Sbjct: 141 GISRNRNENEGKTLLIINGAGGVGSIATQIAKAYGLRVITTASRNETIEWTKKMGADIVL 200 Query: 199 NHRE 202 NH+E Sbjct: 201 NHKE 204 >2EER-A nrPDB Length = 347 Score = 105 bits (261), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 106/361 (29%), Positives = 165/361 (45%), Gaps = 55/361 (15%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPL--- 64 MRA+R+ E G P LKL DI +P PK QVLIK+ A GV + ++R G + + Sbjct: 1 MRAMRLVEIGKP--LKL-EDIPIPKPKGSQVLIKIEAAGVCHSDVHMRQGRFGNLRIVED 57 Query: 65 ----LPYTPGSDVAGVIEAVGDNASAFKKGDRV--------------------------F 94 LP T G ++AG IE VGD + KGD V + Sbjct: 58 LGVKLPVTLGHEIAGRIEEVGDEVVGYSKGDLVAVNPWEGEGNCYYCRIGEEHLCDSPRW 117 Query: 95 TSSTISGGYAEYALAADHT-VYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVL 153 G YAEY L + +YKL +L + A + T YRA + A + ++++ Sbjct: 118 LGINYDGAYAEYVLVPHYKYLYKL-RRLSAVEAAPLTCSGVTTYRA-VRKASLDPSKTLV 175 Query: 154 VHGASGGVGLAACQIARAY-GLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKY 212 V GA GG+G A QIA+A G I+G EE + + GA V N + + +I++ Sbjct: 176 VIGAGGGLGTMAIQIAKAVSGATIIGVDVREEALEAAKRAGADYVINASSQDPVSEIRRI 235 Query: 213 VGEKGIDIIIEMLANVNLSKDLSL----LSHGGRVIVVGSRGT-IEINPRDTMAKESSII 267 KG D +I++ N K LS+ L+ G+ ++VG G ++ + E I Sbjct: 236 TQGKGADAVIDL---NNSEKTLSIYPYVLAKQGKYVMVGLFGADLKYHAPLITLNEVQFI 292 Query: 268 GVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 G + + +F + + E G +KP++ LE+ EA +N + A G+ +L Sbjct: 293 GSLV--GNQSDF----LGIMSLAEAGKVKPMVTKTMKLEEANEAIDN-LENFKAVGRQVL 345 Query: 328 L 328 + Sbjct: 346 V 346 >4EYE-A nrPDB Length = 342 Score = 104 bits (260), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 97/332 (29%), Positives = 160/332 (48%), Gaps = 15/332 (4%) Query: 4 GQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKP 63 G M+A++ GPE L + +D+ P + V++ V A GV + + G Y K Sbjct: 18 GPGSMKAIQAQSLSGPEGL-VYTDVETPGAGPNVVVVDVKAAGVCFPDYLMTKGEYQLKM 76 Query: 64 LLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDF 123 P+ PG + AGV+ + + S K GDRV + I GGYAE A + P +LD Sbjct: 77 EPPFVPGIETAGVVRSAPEG-SGIKPGDRVMAFNFI-GGYAERVAVAPSNILPTPPQLDD 134 Query: 124 KQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTE 183 + A+ Y T Y A ++AGE+VLV GA+GG+G AA QIA+ G K++ Sbjct: 135 AEAVALIANYHTMYFAYARRGQLRAGETVLVLGAAGGIGTAAIQIAKGMGAKVIAVVNRT 194 Query: 184 EGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRV 243 + V GA V E + +++ G G+D++++ + + L+ GR+ Sbjct: 195 AATEFVKSVGADIVLPLEE-GWAKAVREATGGAGVDMVVDPIGGPAFDDAVRTLASEGRL 253 Query: 244 IVVGSRG----TIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGME---IGWLK 296 +VVG TI++N + + +S+IGV + Y QAG+E ++ Sbjct: 254 LVVGFAAGGIPTIKVN--RLLLRNASLIGVA-WGEFLRTHADYLYETQAGLEKLVAEGMR 310 Query: 297 PVIGSQYPLEKVAEAHENIIHGSGATGKMILL 328 P + ++ PL + +A ++ G GKM+L+ Sbjct: 311 PPVSARIPLSEGRQALQDFADGK-VYGKMVLV 341 >3TQH-A nrPDB Length = 321 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 78/240 (32%), Positives = 124/240 (51%), Gaps = 21/240 (8%) Query: 2 ATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGT-YS 60 + K M+A++ +FG P+VLKL D P + +Q+LIKVHA +NP++ R+G+ + Sbjct: 1 SNAMKEMKAIQFDQFGPPKVLKL-VDTPTPEYRKNQMLIKVHAASLNPIDYKTRNGSGFV 59 Query: 61 RKPL---LPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISG---GYAEYALAADHTV 114 K L LP G D +G + +G + + GD+V + YAEY A+ T+ Sbjct: 60 AKKLKNNLPSGLGYDFSGEVIELGSDVNNVNIGDKVMGIAGFPDHPCCYAEYVCASPDTI 119 Query: 115 YKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGL 174 + EKL F Q A++ TA +AL + A VK G+ VL+H +GGVG A Q+A+ G Sbjct: 120 IQKLEKLSFLQAASLPTAGLTALQAL-NQAEVKQGDVVLIHAGAGGVGHLAIQLAKQKGT 178 Query: 175 KILGTAGTEEGQKIVLQNGAHEVFNHREVNY-----------IDKIKKYVGEKGIDIIIE 223 ++ TA ++ + GA + N+ E ++ ID + VG + ID + E Sbjct: 179 TVITTA-SKRNHAFLKALGAEQCINYHEEDFLLAISTPVDAVIDLVGGDVGIQSIDCLKE 237 >3PII-A nrPDB Length = 339 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 101/351 (28%), Positives = 167/351 (47%), Gaps = 44/351 (12%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67 M+A V +F P LK++ ++ P +VL+++ ACGV + + G + KP LP Sbjct: 1 MKAAVVEQFKEP--LKIK-EVEKPTISYGEVLVRIKACGVCHTDLHAAHGDWPVKPKLPL 57 Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRV-----FTSS----------------------TIS 100 PG + G++E VG + K GDRV +++ ++ Sbjct: 58 IPGHEGVGIVEEVGPGVTHLKVGDRVGIPWLYSACGHCDYCLSGQETLCEHQKNAGYSVD 117 Query: 101 GGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGG 160 GGYAEY AA V K+P+ L F++ A I T Y+AL + K GE V ++G GG Sbjct: 118 GGYAEYCRAAADYVVKIPDNLSFEEAAPIFCAGVTTYKALKVTG-AKPGEWVAIYGI-GG 175 Query: 161 VGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGID- 219 G A Q A+A GL ++ +E ++ + GA V N + + +K+ VG G+ Sbjct: 176 FGHVAVQYAKAMGLNVVAVDIGDEKLELAKELGADLVVNPLKEDAAKFMKEKVG--GVHA 233 Query: 220 IIIEMLANVNLSKDLSLLSHGGRVIVVG-SRGTIEINPRDTMAKESSIIGVTLFSSTKEE 278 ++ ++ + + GG ++VG + I DT+ IIG + T+++ Sbjct: 234 AVVTAVSKPAFQSAYNSIRRGGACVLVGLPPEEMPIPIFDTVLNGIKIIGSIV--GTRKD 291 Query: 279 FQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 Q+ ALQ E G +K +I Q PLEK+ E + ++ G G+++L L Sbjct: 292 LQE---ALQFAAE-GKVKTIIEVQ-PLEKINEVFDRMLKGQ-INGRVVLTL 336 >5A3V-A nrPDB Length = 329 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 103/337 (30%), Positives = 161/337 (47%), Gaps = 28/337 (8%) Query: 6 KLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLL 65 KLM A++ +GG + VP PK ++V +K+ A +NPV+ I+ G +P L Sbjct: 4 KLMHALQYNSYGGGAAGLEHVQVPVPTPKSNEVCLKLEATSLNPVDWKIQKGMI--RPFL 61 Query: 66 PYT----PGSDVAGVIEAVGDNASAFKKGDRVFT--SSTISGGYAEYALAADHTVYKLPE 119 P P +DVAG + VG FK GD+V S GG AE+A+A + K P+ Sbjct: 62 PRKFPCIPATDVAGEVVEVGSGVKNFKAGDKVVAVLSHLGGGGLAEFAVATEKLTVKRPQ 121 Query: 120 KLDFKQGAAIGIPYFTAYRALIHSACVK-----AGESVLVHGASGGVGLAACQIARAYGL 174 ++ + AA+ + TA +AL + A +K ++LV ASGGVG A Q+A+ Sbjct: 122 EVGAAEAAALPVAGLTALQALTNPAGLKLDGTGKKANILVTAASGGVGHYAVQLAKLANA 181 Query: 175 KILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDL 234 + T G + V GA EV +++ +K G+K D ++ + S Sbjct: 182 HVTATCGARNIE-FVKSLGADEVLDYKTPEGA-ALKSPSGKK-YDAVVHCANGIPFSVFE 238 Query: 235 SLLSHGGRVIVV----GSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGM 290 LS G+VI + + T + + TM+K+ V L K E ++ L + Sbjct: 239 PNLSENGKVIDITPGPNAMWTYAVK-KITMSKKQL---VPLLLIPKAENLEFMVNL---V 291 Query: 291 EIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 + G +K VI S++PL K +A I G ATGK+I+ Sbjct: 292 KEGKVKTVIDSKHPLSKAEDAWAKSIDGH-ATGKIIV 327 >1LLU-A nrPDB Length = 342 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 74/269 (27%), Positives = 128/269 (47%), Gaps = 33/269 (12%) Query: 6 KLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLL 65 + M+A V +G P L++ ++ VP+P QVL+K+ A GV + + G + KP L Sbjct: 5 QTMKAAVVHAYGAP--LRIE-EVKVPLPGPGQVLVKIEASGVCHTDLHAAEGDWPVKPPL 61 Query: 66 PYTPGSDVAGVIEAVGDNASAFKKGDRV---------------------------FTSST 98 P+ PG + G + AVG + K+GDRV T + Sbjct: 62 PFIPGHEGVGYVAAVGSGVTRVKEGDRVGIPWLYTACGCCEHCLTGWETLCESQQNTGYS 121 Query: 99 ISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGAS 158 ++GGYAEY LA + V LP+ ++F + A I T Y+ L + + G+ V + G Sbjct: 122 VNGGYAEYVLADPNYVGILPKNVEFAEIAPILCAGVTVYKGLKQTN-ARPGQWVAISGI- 179 Query: 159 GGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGI 218 GG+G A Q ARA GL + + ++ + GA N R+ + ++ I++ +G Sbjct: 180 GGLGHVAVQYARAMGLHVAAIDIDDAKLELARKLGASLTVNARQEDPVEAIQRDIG-GAH 238 Query: 219 DIIIEMLANVNLSKDLSLLSHGGRVIVVG 247 +++ ++N + + + GG + +VG Sbjct: 239 GVLVTAVSNSAFGQAIGMARRGGTIALVG 267 >4DVJ-A nrPDB Length = 363 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 62/178 (34%), Positives = 91/178 (51%), Gaps = 9/178 (5%) Query: 31 PIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKG 90 P P H +L++V A VNPV+ +R T G D AG++ AVG + + F+ G Sbjct: 48 PAPAGHDILVEVKAVSVNPVDYKVRRSTPPDGTDWKVI-GYDAAGIVSAVGPDVTLFRPG 106 Query: 91 DRVFTSSTI--SGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVK- 147 D VF + +I G AE+ L + V + P+ LD+ + AA+ + TA+ A V Sbjct: 107 DEVFYAGSIIRPGTNAEFHLVDERIVGRKPKTLDWAEAAALPLTSITAWEAFFDRLDVNK 166 Query: 148 ----AGESVLVHGASGGVGLAACQIARAY-GLKILGTAGTEEGQKIVLQNGAHEVFNH 200 A ++L+ G +GGVG A QIAR L ++ TA E Q+ V GAH V +H Sbjct: 167 PVPGAAPAILIVGGAGGVGSIAVQIARQRTDLTVIATASRPETQEWVKSLGAHHVIDH 224 >2VN8-A nrPDB Length = 375 Score = 94.4 bits (233), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 90/352 (25%), Positives = 163/352 (46%), Gaps = 47/352 (13%) Query: 15 EFGGPEVLKLRSDIAVPIPK-DHQVLIKVHACGVNPVETYIRSG------TYSRKPL--- 64 ++G EVL+ ++ +PI ++V++KVHA VNP++ +RSG R PL Sbjct: 29 KYGKNEVLRFTQNMMMPIIHYPNEVIVKVHAASVNPIDVNMRSGYGATALNMKRDPLHVK 88 Query: 65 -----LPYTPGSDVAGVIEAVGDNASAFKKGDRVFTS--STISGGYAEYALAADHTVYKL 117 P T G DV+GV+ G + FK GD V+ + G +E+ + + + V Sbjct: 89 IKGEEFPLTLGRDVSGVVMECGLDVKYFKPGDEVWAAVPPWKQGTLSEFVVVSGNEVSHK 148 Query: 118 PEKLDFKQGAAIGIPYFTAYRA------LIHSACVKAGESVLVHGASGGVGLAACQIARA 171 P+ L Q A++ TA+ A L C G+ VL+ GASGGVG A Q+ +A Sbjct: 149 PKSLTHTQAASLPYVALTAWSAINKVGGLNDKNC--TGKRVLILGASGGVGTFAIQVMKA 206 Query: 172 YGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEML--ANVN 229 + + +++ ++V + GA +V +++ + +++K K D I++ + + Sbjct: 207 WDAHVTAVC-SQDASELVRKLGADDVIDYKSGSVEEQLKSL---KPFDFILDNVGGSTET 262 Query: 230 LSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQ-----YAA 284 + D G + + + + ++ R +A GVT+ S + F + +A Sbjct: 263 WAPDFLKKWSGATYVTLVTPFLLNMD-RLGIADGMLQTGVTVGSKALKHFWKGVHYRWAF 321 Query: 285 ALQAG---------MEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 + +G ++ G ++PVI +P KV EA + G A GK ++ Sbjct: 322 FMASGPCLDDIAELVDAGKIRPVIEQTFPFSKVPEAFLKVERGH-ARGKTVI 372 >3QWB-A nrPDB Length = 334 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 85/330 (25%), Positives = 149/330 (45%), Gaps = 20/330 (6%) Query: 9 RAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYT 68 + + + E GG +V+K D VP + ++LIK GVN +E+Y R G Y + PY Sbjct: 10 KVILIDEIGGYDVIKYE-DYPVPSISEEELLIKNKYTGVNYIESYFRKGIYPCEK--PYV 66 Query: 69 PGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYA-LAADHTVYKLPE---KLDFK 124 G + +G + A G + F+ GD+V S + +A+Y+ +++ V KLP+ + K Sbjct: 67 LGREASGTVVAKGKGVTNFEVGDQVAYIS--NSTFAQYSKISSQGPVMKLPKGTSDEELK 124 Query: 125 QGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEE 184 AA + TA + VK G+ VL+ A+GGVGL Q+ + G + A T+E Sbjct: 125 LYAAGLLQVLTALSFTNEAYHVKKGDYVLLFAAAGGVGLILNQLLKMKGAHTIAVASTDE 184 Query: 185 GQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVI 244 KI + GA + N + + + ++ K+ KG+D + + L+ L G + Sbjct: 185 KLKIAKEYGAEYLINASKEDILRQVLKFTNGKGVDASFDSVGKDTFEISLAALKRKGVFV 244 Query: 245 VVGSRGTI-------EINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKP 297 G+ + ++P++ + G + + EE++ Y+ + L Sbjct: 245 SFGNASGLIPPFSITRLSPKNITLVRPQLYG---YIADPEEWKYYSDEFFGLVNSKKLNI 301 Query: 298 VIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 I YPL A + I GK++L Sbjct: 302 KIYKTYPLRDYRTAAAD-IESRKTVGKLVL 330 >1R37-A nrPDB Length = 347 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 107/360 (29%), Positives = 165/360 (45%), Gaps = 53/360 (14%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPL--- 64 MRAVR+ E G P L+ +I VP PK QVLIKV A GV + ++R G + + Sbjct: 1 MRAVRLVEIGKPLSLQ---EIGVPKPKGPQVLIKVEAAGVCHSDVHMRQGRFGNLRIVED 57 Query: 65 ----LPYTPGSDVAGVIEAVGDNASAFKKGDRV--------------------------F 94 LP T G ++AG IE VGD + KGD V + Sbjct: 58 LGVKLPVTLGHEIAGKIEEVGDEVVGYSKGDLVAVNPWQGEGNCYYCRIGEEHLCDSPRW 117 Query: 95 TSSTISGGYAEYALAADHT-VYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVL 153 G YAEY + + +YKL +L+ + A + T YRA + A + +++L Sbjct: 118 LGINFDGAYAEYVIVPHYKYMYKL-RRLNAVEAAPLTCSGITTYRA-VRKASLDPTKTLL 175 Query: 154 VHGASGGVGLAACQIARAY-GLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKY 212 V GA GG+G A QIA+A G I+G EE + + GA V N + + +I++ Sbjct: 176 VVGAGGGLGTMAVQIAKAVSGATIIGVDVREEAVEAAKRAGADYVINASMQDPLAEIRRI 235 Query: 213 VGEKGIDIIIEMLANVNLSKDLSL----LSHGGRVIVVGSRGTIEINPRDTMAKESSIIG 268 KG+D +I++ N K LS+ L+ G+ ++VG G +++ + S I Sbjct: 236 TESKGVDAVIDL---NNSEKTLSVYPKALAKQGKYVMVGLFGA-DLHYHAPLITLSEIQF 291 Query: 269 VTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILL 328 V + +F + E G +KP+I LE+ EA +N + A G+ +L+ Sbjct: 292 VGSLVGNQSDF----LGIMRLAEAGKVKPMITKTMKLEEANEAIDN-LENFKAIGRQVLI 346 >3S2F-A nrPDB Length = 340 Score = 89.7 bits (221), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 72/268 (26%), Positives = 121/268 (45%), Gaps = 33/268 (12%) Query: 7 LMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLP 66 +M+A V FG P + ++ VP P QV +K+ A GV + + G + KP LP Sbjct: 2 MMKAAVVRAFGAPLTI---DEVPVPQPGPGQVQVKIEASGVCHTDLHAADGDWPVKPTLP 58 Query: 67 YTPGSDVAGVIEAVGDNASAFKKGDRV---------------------------FTSSTI 99 + PG + G + AVG S K+GDRV T ++ Sbjct: 59 FIPGHEGVGYVSAVGSGVSRVKEGDRVGVPWLYSACGYCEHCLQGWETLCEKQQNTGYSV 118 Query: 100 SGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASG 159 +GGY EY +A + V LP+K+ F + A I T Y+ L + G+ V++ G G Sbjct: 119 NGGYGEYVVADPNYVGLLPDKVGFVEIAPILCAGVTVYKGL-KVTDTRPGQWVVISGI-G 176 Query: 160 GVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGID 219 G+G A Q ARA GL++ + + + GA N R+ + ++K +G Sbjct: 177 GLGHVAVQYARAMGLRVAAVDIDDAKLNLARRLGAEVAVNARDTDPAAWLQKEIG-GAHG 235 Query: 220 IIIEMLANVNLSKDLSLLSHGGRVIVVG 247 +++ ++ S+ + ++ GG + + G Sbjct: 236 VLVTAVSPKAFSQAIGMVRRGGTIALNG 263 >4IDE-A nrPDB Length = 332 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 99/322 (30%), Positives = 158/322 (49%), Gaps = 43/322 (13%) Query: 20 EVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRK--PLLPYTPGSDVAGVI 77 +VLK +AVP K+ QVLIKV A +NPV+ + R+ Y + LP PG DVAGV+ Sbjct: 37 DVLKFDPSVAVPEIKEDQVLIKVVAASLNPVD-FKRALGYFKDTDSPLPTIPGYDVAGVV 95 Query: 78 EAVGDNASAFKKGDRVF--------TSSTISGGYAEYALAADHTVYKLPEKLDFKQGAAI 129 VG + FK GD V+ + T G AEY A + + P+ L F + A++ Sbjct: 96 VKVGSQVTKFKVGDEVYGDLNETALVNPTRFGSLAEYTAADERVLAHKPKNLSFIEAASL 155 Query: 130 GIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIAR-AYGL-KILGTAGTEEGQK 187 + TA+ L A + AG+SVLV G +GGVG Q+A+ +G K+ TA T++ Sbjct: 156 PLAIETAHEGL-ERAELSAGKSVLVLGGAGGVGTHIIQLAKHVFGASKVAATASTKK-LD 213 Query: 188 IVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVG 247 ++ GA ++ + N+ D +K+ D++ + + + K + + GG+V+ + Sbjct: 214 LLRTLGADLAIDYTKENFEDLPEKF------DVVYDAVGETD--KAVKAVKEGGKVVTIV 265 Query: 248 SRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG--SQYPL 305 T + + +T S E+ + Y +E G +KPV+ S YP Sbjct: 266 GPAT----------PPAILFVLTSKGSVLEKLKPY-------LESGKVKPVLDPTSPYPF 308 Query: 306 EKVAEAHENIIHGSGATGKMIL 327 KV EA + S ATGK+++ Sbjct: 309 TKVVEAF-GYLESSRATGKVVV 329 >3MEQ-A nrPDB Length = 365 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 69/270 (25%), Positives = 116/270 (42%), Gaps = 33/270 (12%) Query: 6 KLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLL 65 K M+A V FG P + ++ +P P Q+ + + A GV + + G + KP Sbjct: 24 KTMKAAVVRAFGKPLTI---DEVPIPQPGPGQIQVAIQASGVCHTDLHAAEGDWPVKPNP 80 Query: 66 PYTPGSDVAGVIEAVGDNASAFKKGDRV---------------------------FTSST 98 P+ PG + G + AVG K+GDRV T + Sbjct: 81 PFIPGHEGVGFVSAVGSGVKHVKEGDRVGIPWLYTACGHCRHCLGGWETLCEEQLNTGYS 140 Query: 99 ISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGAS 158 ++GG+AEY +A + V LP+ +DF + A + T Y+ L K G+ V++ G Sbjct: 141 VNGGFAEYVVADPNFVGHLPKNIDFNEIAPVLCAGVTVYKGL-KVTDTKPGDWVVISGI- 198 Query: 159 GGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREV-NYIDKIKKYVGEKG 217 GG+G A Q ARA GL + + + + GA N + V + I+K Sbjct: 199 GGLGHMAVQYARAMGLNVAAVDIDDRKLDLARRLGATVTVNAKTVADPAAYIRKETDGGA 258 Query: 218 IDIIIEMLANVNLSKDLSLLSHGGRVIVVG 247 +++ ++ + L +++ GG V + G Sbjct: 259 QGVLVTAVSPKAFEQALGMVARGGTVSLNG 288 >1V3V-A nrPDB Length = 333 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 64/222 (28%), Positives = 104/222 (46%), Gaps = 8/222 (3%) Query: 28 IAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAF 87 + +P K+ +VL++ V+P Y+R + R G VA V+E+ SAF Sbjct: 31 VELPPLKNGEVLLEALFLSVDP---YMRIAS-KRLKEGAVMMGQQVARVVES---KNSAF 83 Query: 88 KKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQG-AAIGIPYFTAYRALIHSACV 146 G V S + + + + + P+KL IG+P TAY L+ V Sbjct: 84 PAGSIVLAQSGWTTHFISDGKGLEKLLTEWPDKLPLSLALGTIGMPGLTAYFGLLEVCGV 143 Query: 147 KAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYI 206 K GE+VLV A+G VG QIA+ G K++G AG++E + Q G FN++ VN + Sbjct: 144 KGGETVLVSAAAGAVGSVVGQIAKLKGCKVVGAAGSDEKIAYLKQIGFDAAFNYKTVNSL 203 Query: 207 DKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGS 248 ++ K G D + + L+ LS + G++ + G+ Sbjct: 204 EEALKKASPDGYDCYFDNVGGEFLNTVLSQMKDFGKIAICGA 245 >4Z6K-A nrPDB Length = 346 Score = 78.6 bits (192), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 82/339 (24%), Positives = 152/339 (44%), Gaps = 41/339 (12%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67 M+A + EFG + L++ ++ +P P ++++K+ A GV + + G + KP P+ Sbjct: 1 MKAAVLHEFG--QSLQIE-EVDIPTPGAGEIVVKMQASGVCHTDLHAVEGDWPVKPSPPF 57 Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRV---------------------------FTSSTIS 100 PG + G+I AVG+ + K+GDRV + +++ Sbjct: 58 IPGHEGVGLITAVGEGVTHVKEGDRVGVAWLYSACGHCTHCLGGWETLCESQQNSGYSVN 117 Query: 101 GGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGG 160 G +AEY LA + V +PE +D + A + T Y+ L + K G+ V++ G GG Sbjct: 118 GSFAEYVLANANYVGIIPESVDSIEIAPVLCAGVTVYKGLKMTD-TKPGDWVVISGI-GG 175 Query: 161 VGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDI 220 +G A Q A A GL + ++ + GA N + + + ++K +G + Sbjct: 176 LGHMAVQYAIAMGLNVAAVDIDDDKLAFAKKLGAKVTVNAKNTDPAEYLQKEIGGAHGAL 235 Query: 221 IIEMLANVNLSKDLSLLSHGGRVIVVG-SRGTIEINPRDTMAKESSIIGVTLFSSTKEEF 279 + + A + LS+L GG ++ G G ++ DT+ +I G + T+ + Sbjct: 236 VTAVSAKA-FDQALSMLRRGGTLVCNGLPPGDFPVSIFDTVLNGITIRGSIV--GTRLDL 292 Query: 280 QQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHG 318 Q+ AG +K + ++ PLE + + E + G Sbjct: 293 QESLDMAAAGK----VKATVTAE-PLENINDIFERMRQG 326 >3HZZ-A nrPDB Length = 467 Score = 77.8 bits (190), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 93/361 (25%), Positives = 141/361 (39%), Gaps = 80/361 (22%) Query: 30 VPIPK--DHQVLIKVHACGVN----------PVETYIRSGTYSR-KPL-----LPY-TPG 70 VP+P+ + L+ V A VN PV T+ Y + PL LPY G Sbjct: 81 VPVPELGPGEALVAVMASSVNYNSVWTSIFEPVSTFAFLERYGKLSPLTKRHDLPYHIIG 140 Query: 71 SDVAGVIEAVGDNASAFKKGD--------------------------RVFTSSTISGGYA 104 SD+AGV+ G +A++ GD R++ T GG A Sbjct: 141 SDLAGVVLRTGPGVNAWQPGDEVVAHCLSVELESPDGHDDTMLDPEQRIWGFETNFGGLA 200 Query: 105 EYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALI--HSACVKAGESVLVHGASGGVG 162 E AL + + P+ L +++ AA G+ TAYR L+ + A +K G++VL+ GASGG+G Sbjct: 201 EIALVKTNQLMPKPKHLTWEEAAAPGLVNSTAYRQLVSRNGAAMKQGDNVLIWGASGGLG 260 Query: 163 LAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYI---------------- 206 A Q A A G + + + +I GA + + Y Sbjct: 261 SYATQFALAGGANPICVVSSPQKAEICRSMGAEAIIDRNAEGYKFWKDEHTQDPKEWKRF 320 Query: 207 -DKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTI--EINPRDTMAKE 263 +I++ G + IDI+ E + + GG + S E + R Sbjct: 321 GKRIRELTGGEDIDIVFEHPGRETFGASVYVTRKGGTITTCASTSGYMHEYDNRYLWMSL 380 Query: 264 SSIIGVTLFSSTKEEFQQYAAALQAGMEI--GWLKPVIGSQYPLEKVAEA----HENIIH 317 IIG F Y A +A I G + P + Y LE+ +A H N+ Sbjct: 381 KRIIG--------SHFANYREAYEANRLIAKGKIHPTLSKTYSLEETGQAAYDVHRNLHQ 432 Query: 318 G 318 G Sbjct: 433 G 433 >2VCY-A nrPDB Length = 344 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 42/141 (29%), Positives = 74/141 (52%) Query: 38 VLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSS 97 V +K+ A +NP + + G Y P LP G++ + AVG N + K GD V ++ Sbjct: 44 VRVKMLAAPINPSDINMIQGNYGLLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPAN 103 Query: 98 TISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGA 157 G + A+ ++ + ++P + + A +G+ TAYR L+ ++ G+SV+ + + Sbjct: 104 AGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNAS 163 Query: 158 SGGVGLAACQIARAYGLKILG 178 + GVG A QIA A GL+ + Sbjct: 164 NSGVGQAVIQIAAALGLRTIN 184 >5ENV-A nrPDB Length = 347 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 60/199 (30%), Positives = 89/199 (44%), Gaps = 29/199 (14%) Query: 27 DIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASA 86 DI VP PK +++LI V GV + + G + LP G + AGV+ +G+N Sbjct: 22 DIPVPKPKANELLINVKYSGVCHTDLHAWHGDWPLPVKLPLVGGHEGAGVVVGMGENVKG 81 Query: 87 FKKGDRV---------------------------FTSSTISGGYAEYALAADHTVYKLPE 119 +K GD + T G + +YA A +P+ Sbjct: 82 WKIGDYAGIKWLNGSCMACEYCELGNESNCPHADLSGYTHDGSFQQYATADAVQAAHIPQ 141 Query: 120 KLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGT 179 D Q A I T Y+AL SA + AG V + GA+GG+G A Q A+A G ++LG Sbjct: 142 GTDLAQVAPILCAGITVYKAL-KSANLMAGHWVAISGAAGGLGSLAVQYAKAMGYRVLGI 200 Query: 180 AGTEEGQKIVLQNGAHEVF 198 G EG++ + ++ EVF Sbjct: 201 DGG-EGKEELFRSIGGEVF 218 >6N7L-A nrPDB Length = 353 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 77/305 (25%), Positives = 141/305 (46%), Gaps = 39/305 (12%) Query: 6 KLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLL 65 K M+A V +G P LK++ ++ V P ++VL+KV ACGV + + G + KP + Sbjct: 12 KTMKAAVVQGYGEP--LKIQ-EVPVREPGRYEVLVKVMACGVCHTDLHAVDGDWPAKPKM 68 Query: 66 PYTPGSDVAGVIEAVGDNASAFKKGDRV-----FTSS----------------------T 98 P PG + G++ A G +A K+GD V +++ + Sbjct: 69 PLIPGHEGVGIVVACGPDA-MVKEGDAVGVPWLYSACGCCDYCITGWETLCEAQQNGGYS 127 Query: 99 ISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGAS 158 + GG+AEY +A V L ++F + A I T Y+ L + K GE V + G Sbjct: 128 VDGGFAEYVIADSRYVGHLKSNVNFLEIAPILCAGVTVYKGLKETE-TKPGEWVAISGI- 185 Query: 159 GGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGI 218 GG+G A Q A+A G+ + ++ ++ + GA N + + + K VG G+ Sbjct: 186 GGLGHVAVQYAKAMGMHVAAIDVADDKLELAKKLGADLTVNAKTTDPGTYLHKEVG--GM 243 Query: 219 D-IIIEMLANVNLSKDLSLLSHGGRVIVVG-SRGTIEINPRDTMAKESSIIGVTLFSSTK 276 +I ++ + + + +L G + + G G+ E+ +T+ K ++ G + T+ Sbjct: 244 HGALITAVSPIAFKQGIDVLRRKGTIALNGLPPGSFELPIFETVLKRITVRGSIV--GTR 301 Query: 277 EEFQQ 281 ++ Q+ Sbjct: 302 KDLQE 306 >4EJ6-A nrPDB Length = 370 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 75/301 (24%), Positives = 127/301 (42%), Gaps = 50/301 (16%) Query: 5 QKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPL 64 Q +M+AVR+ G V ++ +P P +L+KV ACG+ + ++ G + P Sbjct: 21 QSMMKAVRLESVGNISV----RNVGIPEPGPDDLLVKVEACGICGTDRHLLHGEFPSTP- 75 Query: 65 LPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTIS------------------------ 100 P T G + G++ G G R+ IS Sbjct: 76 -PVTLGHEFCGIVVEAGSAVRDIAPGARITGDPNISCGRCPQCQAGRVNLCRNLRAIGIH 134 Query: 101 --GGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHS---ACVKAGESVLVH 155 GG+AEY L +++P LD GA + +H + +KAG +V + Sbjct: 135 RDGGFAEYVLVPRKQAFEIPLTLDPVHGA-----FCEPLACCLHGVDLSGIKAGSTVAIL 189 Query: 156 GASGGVGLAACQIARAYGLK--ILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYV 213 G G +GL Q+AR G IL T + +++ + GA + + ++ I V Sbjct: 190 GG-GVIGLLTVQLARLAGATTVILSTRQATK-RRLAEEVGATATVDPSAGDVVEAIAGPV 247 Query: 214 G--EKGIDIIIEMLANVNLSKDLSLLSH-GGRVIVVG--SRG-TIEINPRDTMAKESSII 267 G G+D++IE K + L+ GG V+++G +G +EI P D + +E ++ Sbjct: 248 GLVPGGVDVVIECAGVAETVKQSTRLAKAGGTVVILGVLPQGEKVEIEPFDILFRELRVL 307 Query: 268 G 268 G Sbjct: 308 G 308 >5VM2-A nrPDB Length = 347 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 62/252 (24%), Positives = 110/252 (43%), Gaps = 36/252 (14%) Query: 30 VPIPKDHQVLIKVHACGVNPVETY-IRSGTY--SRKPLLPYTPGSDVAGVIEAVGDNASA 86 +P+PK+ +VLIKV G+ + + SG + + P G + AG + AVG Sbjct: 21 IPVPKEDEVLIKVEYVGICGSDVHGFESGPFIPPKDPNQEIGLGHECAGTVVAVGSRVRK 80 Query: 87 FKKGDRVFTSSTISGGYAEYALAADHTV----------------------------YKLP 118 FK GDRV + G+ Y L + + YKLP Sbjct: 81 FKPGDRVNIEPGVPCGHCRYCLEGKYNICPDVDFMATQPNYRGALTHYLCHPESFTYKLP 140 Query: 119 EKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILG 178 + +D +G + + A++ A VK G+ +++ GA G +GL Q + G + Sbjct: 141 DNMDTMEGTLVEPAAVGMHAAML--ADVKPGKKIIILGA-GCIGLMTLQACKCLGATEIA 197 Query: 179 TAGTEEGQ-KIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLAN-VNLSKDLSL 236 E + + Q GA V N + + I + +++ + G DI+ E + V + + L Sbjct: 198 VVDVLEKRLAMAEQLGATVVINGAKEDTIARCQQFTEDMGADIVFETAGSAVTVKQAPYL 257 Query: 237 LSHGGRVIVVGS 248 + GG++++VG+ Sbjct: 258 VMRGGKIMIVGT 269 >4A10-A nrPDB Length = 447 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 93/365 (25%), Positives = 139/365 (38%), Gaps = 73/365 (20%) Query: 30 VPIPK--DHQVLIKVHACGVN----------PVETY------IRSGTYSRKPLLPY-TPG 70 VP+P+ +VL+ V A +N P+ T+ R G ++ + PY G Sbjct: 55 VPMPELAPDEVLVAVMASSINYNTVWSAMFEPIPTFHFLKQNARQGGWATRHDQPYHVLG 114 Query: 71 SDVAGVIEAVGDNASAFKKGD--------------------------RVFTSSTISGGYA 104 SD +GV+ G +K GD R + T GG A Sbjct: 115 SDCSGVVVRTGIGVRRWKPGDHVIVHPAHVDEQEPATHGDGMLGTEQRAWGFETNFGGLA 174 Query: 105 EYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALI--HSACVKAGESVLVHGASGGVG 162 EY + + P L +++ A + TAYR L+ A +K G+ VL+ GASGG+G Sbjct: 175 EYGVVRASQLLPKPAHLTWEEAAVSPLCAGTAYRMLVSDRGAQMKQGDIVLIWGASGGLG 234 Query: 163 LAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYID--------------K 208 A Q + G + + + + V G V N E+ D K Sbjct: 235 SYAIQFVKNGGGIPVAVVSSAQKEAAVRALGCDLVINRAELGITDDIADDPRRVVETGRK 294 Query: 209 IKKYVGEKG---IDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTI--EINPRDTMAKE 263 + K V EK DI+ E V + + GG V+ GS + R K Sbjct: 295 LAKLVVEKAGREPDIVFEHTGRVTFGLSVIVARRGGTVVTCGSSSGYLHTFDNRYLWMKL 354 Query: 264 SSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATG 323 I+G E QQ L E G + P + + YPL + AEA ++ S G Sbjct: 355 KKIVGS---HGANHEEQQATNRL---FESGAVVPAMSAVYPLAEAAEAC-RVVQTSRQVG 407 Query: 324 KMILL 328 K+ +L Sbjct: 408 KVAVL 412 >3B70-A nrPDB Length = 371 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 56/220 (25%), Positives = 95/220 (43%), Gaps = 34/220 (15%) Query: 32 IPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGD 91 +P+D QV ++V A +NP +T +R + L G+D AG + AVG + + + GD Sbjct: 34 LPRD-QVYVRVEAVAINPSDTKMRGQFATPWAFL----GTDYAGTVVAVGSDVTHIQVGD 88 Query: 92 RVF-------TSSTISGGYAEYALAADHTVYKLPEKLDFKQGAA---------------- 128 RV+ + G +++Y + K+P+ L F+Q AA Sbjct: 89 RVYGAQNEMCPRTPDQGAFSQYTVTRGRVWAKIPKGLSFEQAAALPAGISTAGLAMKLLG 148 Query: 129 IGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKI 188 + +P +A + HS V VLV+G S Q+ R G + T + + Sbjct: 149 LPLPSPSADQPPTHSKPVY----VLVYGGSTATATVTMQMLRLSGYIPIATC-SPHNFDL 203 Query: 189 VLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANV 228 GA EVF++R N I+ Y + + ++ + NV Sbjct: 204 AKSRGAEEVFDYRAPNLAQTIRTYT-KNNLRYALDCITNV 242 >2WEK-A nrPDB Length = 341 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 59/230 (25%), Positives = 103/230 (44%), Gaps = 8/230 (3%) Query: 20 EVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEA 79 E + L D VP+P D +L++ GVN + +G Y P+ G + G + A Sbjct: 17 EAVTLSRDCPVPLPGDGDLLVRNRFVGVNASDINYSAGRYDPSVKPPFDIGFEGIGEVVA 76 Query: 80 VGDNASA-FKKGDRVFTSSTISGGYAEYALAADHTVYKLPE-KLDFKQGAAIGIPYFTAY 137 +G +ASA + G V + G +AEY + +P K ++ G TAY Sbjct: 77 LGLSASARYTVGQAV--AYMAPGSFAEYTVVPASIATPVPSVKPEYLTLLVSGT---TAY 131 Query: 138 RALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEV 197 +L + G+ VLV A+GG G A Q+++ ++GT ++E + G Sbjct: 132 ISLKELGGLSEGKKVLVTAAAGGTGQFAMQLSKKAKCHVIGTCSSDEKSAFLKSLGCDRP 191 Query: 198 FNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVG 247 N++ + + K +G+D++ E + + L+ GR+IV+G Sbjct: 192 INYK-TEPVGTVLKQEYPEGVDVVYESVGGAMFDLAVDALATKGRLIVIG 240 >4EEZ-A nrPDB Length = 348 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 76/324 (23%), Positives = 147/324 (45%), Gaps = 42/324 (12%) Query: 34 KDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRV 93 K ++ L+ + CGV + ++ +G + K G + G+++ +G + S+ + GDRV Sbjct: 25 KPNEALLDMEYCGVCHTDLHVAAGDFGNKA--GTVLGHEGIGIVKEIGADVSSLQVGDRV 82 Query: 94 FTSS---------------------------TISGGYAEYALAADHTVYKLPEKLDFKQG 126 + ++ GG AE A+ K+P+ LD + Sbjct: 83 SVAWFFEGCGHCEYCVSGNETFCREVKNAGYSVDGGMAEEAIVVADYAVKVPDGLDPIEA 142 Query: 127 AAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIAR-AYGLKILGTAGTEEG 185 ++I T Y+A+ S VK G+ ++ GA GG+G A Q A+ +G K++ ++ Sbjct: 143 SSITCAGVTTYKAIKVSG-VKPGDWQVIFGA-GGLGNLAIQYAKNVFGAKVIAVDINQDK 200 Query: 186 QKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGI-DIIIEMLANVNLSKDLSLLSHGGRVI 244 + + GA N +VN +D+IKK G G+ I+ +A + + ++ L G+++ Sbjct: 201 LNLAKKIGADVTINSGDVNPVDEIKKITGGLGVQSAIVCAVARIAFEQAVASLKPMGKMV 260 Query: 245 VVGSRGTIEINPRDTMAKESSII-GVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQY 303 V N T++ + + GV + S A A Q G E G +KP++ ++ Sbjct: 261 AVAVP-----NTEMTLSVPTVVFDGVEVAGSLVGTRLDLAEAFQFGAE-GKVKPIVATR- 313 Query: 304 PLEKVAEAHENIIHGSGATGKMIL 327 LE++ + + + G G+M++ Sbjct: 314 KLEEINDIIDEMKAGK-IEGRMVI 336 >2Y05-A nrPDB Length = 328 Score = 63.9 bits (154), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 59/227 (25%), Positives = 103/227 (45%), Gaps = 16/227 (7%) Query: 30 VPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKK 89 +P K+ +VL++ V+P Y+R R G VA V+E+ A K Sbjct: 28 LPPLKNGEVLLEALFLTVDP---YMRVAA-KRLKEGDTMMGQQVAKVVES---KNVALPK 80 Query: 90 GDRVFTSSTISGGYAEYALAADHTVYKL----PEKLDFKQG-AAIGIPYFTAYRALIHSA 144 G V S G+ ++++ + KL P+ + +G+P TAY L+ Sbjct: 81 GTIVLASP----GWTTHSISDGKDLEKLLTEWPDTIPLSLALGTVGMPGLTAYFGLLEIC 136 Query: 145 CVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVN 204 VK GE+V+V+ A+G VG QIA+ G K++G G++E + + G VFN++ V Sbjct: 137 GVKGGETVMVNAAAGAVGSVVGQIAKLKGCKVVGAVGSDEKVAYLQKLGFDVVFNYKTVE 196 Query: 205 YIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGT 251 +++ K G D + + + + + GR+ + G+ T Sbjct: 197 SLEETLKKASPDGYDCYFDNVGGEFSNTVIGQMKKFGRIAICGAIST 243 >2J3K-A nrPDB Length = 345 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 71/280 (25%), Positives = 122/280 (43%), Gaps = 26/280 (9%) Query: 67 YTPGSDVAG--VIEAVGDNASAFKKGDRVFTSSTISGGYAEYAL--AADHTVYKLPEK-- 120 YTPG + G V + +KKGD ++ + EY++ H +K+ Sbjct: 72 YTPGQPIQGYGVSRIIESGHPDYKKGDLLWGIV----AWEEYSVITPMTHAHFKIQHTDV 127 Query: 121 -LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGT 179 L + G +G+P TAY K GE+V V ASG VG Q+A+ G ++G+ Sbjct: 128 PLSYYTGL-LGMPGMTAYAGFYEVCSPKEGETVYVSAASGAVGQLVGQLAKMMGCYVVGS 186 Query: 180 AGTEEGQKIV-LQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLS 238 AG++E ++ + G + FN++E + + K GIDI E + L L ++ Sbjct: 187 AGSKEKVDLLKTKFGFDDAFNYKEESDLTAALKRCFPNGIDIYFENVGGKMLDAVLVNMN 246 Query: 239 HGGRVIVVGSRGTIEINPRDTMAKESSIIG---------VTLFSSTKEEFQQYAAALQAG 289 GR+ V G + ++ + S+II V+ F +F ++ Sbjct: 247 MHGRIAVCGMISQYNLENQEGVHNLSNIIYKRNRIQGFVVSDFYDKYSKFLEFVLPHIRE 306 Query: 290 MEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 +I +++ V LEK EA + HG GK ++++ Sbjct: 307 GKITYVEDVADG---LEKAPEALVGLFHGKNV-GKQVVVV 342 >5TNX-A nrPDB Length = 383 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 91/352 (25%), Positives = 140/352 (39%), Gaps = 65/352 (18%) Query: 33 PKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDR 92 P+ +VL++V A G+ + +R Y LP G + AGV+EAVG N GD Sbjct: 40 PRGDEVLVRVVATGLCHTDLIVRDQYYPVP--LPAVLGHEGAGVVEAVGPNVKTLAAGDH 97 Query: 93 VFTS-------STISGG-----------------------------------------YA 104 V + ++ +GG +A Sbjct: 98 VVLTYGACGHCASCAGGHGAYCRQFFALNFGGADADGQTALRDAAGEPLHDHFFAQSSFA 157 Query: 105 EYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLA 164 YALA ++ K+P++ + +G T A+I+S V+ G S GA G VG++ Sbjct: 158 SYALARENNAIKVPKEAPLELLGPLGCGIQTGAGAVINSLAVRTGSSFASFGA-GAVGMS 216 Query: 165 ACQIARAYG-LKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIE 223 A AR G I+ + L+ GA N +EV+ +D I++ G G+D +E Sbjct: 217 AVMAARIAGATTIIAVDIVPSRLALALELGATHAINSKEVDVVDAIREITG-GGVDYALE 275 Query: 224 MLA-NVNLSKDLSLLSHGGRVIVVGSR--GT-IEINPRDTMAKESSIIGVTLFSSTKEEF 279 LS+ + L G + VVG+ GT E + + +I G+ S + F Sbjct: 276 STGLPAVLSQGIDALGSRGTMGVVGAPKLGTKAEFDVNSLLLGGHTIRGIVEGDSVPQTF 335 Query: 280 --QQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 Q LQ L YPLE++ +A + SG T K IL L Sbjct: 336 IPQLVQLHLQGRFPFDRLVKF----YPLEQINQAAAD--SSSGITLKPILRL 381 >2DQ4-A nrPDB Length = 343 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 84/335 (25%), Positives = 143/335 (42%), Gaps = 46/335 (13%) Query: 27 DIAVPIPKDHQVLIKVHACGVNPVETYI-RSGTYSR---KPLLPYTPGSDVAGVIEAVGD 82 D VP P ++L++V A + + +I + ++R +P P G + +GV+EAVG Sbjct: 17 DRPVPEPGPGEILVRVEAASICGTDLHIWKWDAWARGRIRP--PLVTGHEFSGVVEAVGP 74 Query: 83 NASAFKKGDRVFTSSTI--------------------------SGGYAEYALAADHTVYK 116 + GD V S I GG+AEY + + Sbjct: 75 GVRRPQVGDHVSLESHIVCHACPACRTGNYHVCLNTQILGVDRDGGFAEYVVVPAENAWV 134 Query: 117 LPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKI 176 P+ L F+ AAI P+ A + + V +G+SVL+ GA G +GL A + RA G Sbjct: 135 NPKDLPFEV-AAILEPFGNAVHTVYAGSGV-SGKSVLITGA-GPIGLMAAMVVRASGAGP 191 Query: 177 LGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLAN-VNLSKDLS 235 + + + + A + N E + ++ +++ G G+++++E N + + L Sbjct: 192 ILVSDPNPYRLAFARPYADRLVNPLEEDLLEVVRRVTG-SGVEVLLEFSGNEAAIHQGLM 250 Query: 236 LLSHGGRVIVVGSRGTIEINP-RDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGW 294 L GG ++G I +P R +A E + G+T F Q A + G Sbjct: 251 ALIPGGEARILG----IPSDPIRFDLAGELVMRGITAFGIAGRRLWQTWMQGTALVYSGR 306 Query: 295 --LKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 L P++ + PL + EA + SG K+IL Sbjct: 307 VDLSPLLTHRLPLSRYREAFG--LLASGQAVKVIL 339 >4Y1B-A nrPDB Length = 425 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 89/404 (22%), Positives = 156/404 (38%), Gaps = 90/404 (22%) Query: 1 MATGQKLMRA--VRVFEFGGPEVLKLRSDIA-VPIPKDHQVLIKVHACGVNPVETYIRSG 57 + T K M A +R +G P V R+++ VP QVL+KV A GVN + G Sbjct: 34 LGTAPKQMYASLIRQERYGRP-VDAFRTEVVDVPPVGPGQVLVKVMAAGVNYNNVWAALG 92 Query: 58 TYSRKPLLP-------------YTPGSDVAGVIEAVGD-------------------NAS 85 +PL + GSD++G++ AVGD +A Sbjct: 93 ----EPLDVIAARQKQGATEDFHIGGSDLSGIVWAVGDGVRLKPGAEVVVLACRWDESAQ 148 Query: 86 AFKKGDRVFTSSTIS--------GGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAY 137 + G TSST G +A++A+ ++ + P++L + + TAY Sbjct: 149 DIRLGADPVTSSTQRVWGYEENYGSFAQFAVVDEYMCHPKPQRLSWAAASCYMATAATAY 208 Query: 138 RALI--HSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAH 195 R L V+ G+ VL+ G +GG+G A Q+ R G + +EE + ++ GA Sbjct: 209 RQLFGWEPHTVRPGDPVLIWGGAGGLGSIAIQLVRHVGGIPVAVVSSEERGEFCMRLGAK 268 Query: 196 EVFNHREVNYIDKIKKYVGEKGID------------------------IIIEMLANVNLS 231 + RE ++ ++ E+ + I++E + Sbjct: 269 GWIDRREFDHWGRLPDTTDEEAMKQWLDGARAFGRRFWEVLGERRAPRIVLEHSGADTIP 328 Query: 232 KDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGME 291 + + + G V++ G GT N + L+ K +AA+ + E Sbjct: 329 TSIYMADNAGMVVICG--GTTGYN--------GDVDLRFLWMRQKRLQGSHAASAREARE 378 Query: 292 I------GWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 I G + P + + E++ AH+ I +G M +L+ Sbjct: 379 ITRLIDQGAIDPCLSRTFGFEEIGLAHQLIHDNQHPSGNMAVLV 422 >1H2B-A nrPDB Length = 359 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 75/326 (23%), Positives = 141/326 (43%), Gaps = 41/326 (12%) Query: 2 ATGQKLMRAVRVFEFGGPEVLKLRSDIAVP-IPKDHQVLIKVHACGVNPVETYIRSGTYS 60 + G + ++A R+ E+ P L++ D+ P + V++++ GV + ++ G + Sbjct: 10 SLGVERLKAARLHEYNKP--LRI-EDVDYPRLEGRFDVIVRIAGAGVCHTDLHLVQGMWH 66 Query: 61 R--KPLLPYTPGSDVAGVIEAVGDNASAFKKGDRV------------------------- 93 +P LPYT G + G IE V + +KGD V Sbjct: 67 ELLQPKLPYTLGHENVGYIEEVAEGVEGLEKGDPVILHPAVTDGTCLACRAGEDMHCENL 126 Query: 94 -FTSSTISGGYAEYALAADHTVYKLPEKLD---FKQGAAIGIPYFTAYRALIHSA-CVKA 148 F I GG+AE+ + +V KLP+ + + A + TAYRA+ +A + Sbjct: 127 EFPGLNIDGGFAEFMRTSHRSVIKLPKDISREKLVEMAPLADAGITAYRAVKKAARTLYP 186 Query: 149 GESVLVHGASGGVGLAACQIARAYG-LKILGTAGTEEGQKIVLQNGAHEVFNHREVNYID 207 G V + G GG+G A Q+ + ++ EE K+ + GA V + R + + Sbjct: 187 GAYVAIVGV-GGLGHIAVQLLKVMTPATVIALDVKEEKLKLAERLGADHVVDARR-DPVK 244 Query: 208 KIKKYVGEKGIDIIIEML-ANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSI 266 ++ + +G+++ ++ + + + LL GR+I+VG G + ++ E S Sbjct: 245 QVMELTRGRGVNVAMDFVGSQATVDYTPYLLGRMGRLIIVGYGGELRFPTIRVISSEVSF 304 Query: 267 IGVTLFSSTKEEFQQYAAALQAGMEI 292 G +L + E + ALQ + + Sbjct: 305 EG-SLVGNYVELHELVTLALQGKVRV 329 >5GXF-A nrPDB Length = 330 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 49/148 (33%), Positives = 68/148 (45%), Gaps = 12/148 (8%) Query: 66 PYTPGSDVAGVIEAVGDNASAFKKGDRV-FTSSTIS----GGYAEYALAADHTVYKLPEK 120 P+ PG D AG +E D +K GD+V T + GGY++ A + LPE Sbjct: 61 PHVPGIDFAGTVENSSDER--YKPGDKVVLTGWRVGEAHWGGYSQKANVRADWLVPLPEG 118 Query: 121 LDFKQGAAIGIPYFTAYRALI----HSACVKAGESVLVHGASGGVGLAACQIARAYGLKI 176 LD +Q A+G FTA A++ H G VLV GA+GGVG A I G ++ Sbjct: 119 LDTRQAMAVGTAGFTAMLAVMALEDHGLTPGHG-PVLVTGAAGGVGSVATAILAHLGYEV 177 Query: 177 LGTAGTEEGQKIVLQNGAHEVFNHREVN 204 G E + GA ++ E+N Sbjct: 178 AAVTGRPETADYLTSLGATQIVARDEIN 205 >1O89-A nrPDB Length = 345 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 58/221 (26%), Positives = 92/221 (41%), Gaps = 14/221 (6%) Query: 38 VLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTS- 96 V + VH +N + +G P PG D AG + D F G V + Sbjct: 51 VTVDVHWSSLNYKDALAITGKGKIIRNFPMIPGIDFAGTVRTSED--PRFHAGQEVLLTG 108 Query: 97 ----STISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRAL--IHSACVKAGE 150 GG AE A + +P+ LD ++ IG FTA + + A V+ + Sbjct: 109 WGVGENHWGGLAEQARVKGDWLVAMPQGLDARKAMIIGTAGFTAMLCVMALEDAGVRPQD 168 Query: 151 -SVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKI 209 ++V GASGGVG A + G +++ +G E + + GA V E + Sbjct: 169 GEIVVTGASGGVGSTAVALLHKLGYQVVAVSGRESTHEYLKSLGASRVLPRDEFAESRPL 228 Query: 210 KKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRG 250 +K V ID + + + L+K L+ +++GG V G G Sbjct: 229 EKQVWAGAIDTVGDKV----LAKVLAQMNYGGCVAACGLAG 265 >4CPD-A nrPDB Length = 347 Score = 57.4 bits (137), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 79/316 (25%), Positives = 126/316 (39%), Gaps = 54/316 (17%) Query: 39 LIKVHACGVNPVETYIRSGTYSRKPLLPYTPGS----DVAGVIEAVGDNASAFKKGDRVF 94 L++VH G+ + ++ G +P PGS + G +EAVG+ + GD V Sbjct: 29 LVRVHLAGICGSDLHLYHGK------IPVLPGSVLGHEFVGQVEAVGEGIQDLQPGDWVV 82 Query: 95 TSSTISGGYA------EYALAADHTVY---------------------------KLPEKL 121 I+ G +Y L VY KLP L Sbjct: 83 GPFHIACGTCPYCRRHQYNLCERGGVYGYGPMFGNLQGAQAEILRVPFSNVNLRKLPPNL 142 Query: 122 DFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGL-KILGTA 180 ++ G TAY LI ++ G+SV V GA G VGL A ++A+ G KIL Sbjct: 143 SPERAIFAGDILSTAYGGLIQGQ-LRPGDSVAVIGA-GPVGLMAIEVAQVLGASKILAID 200 Query: 181 GTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLAN-VNLSKDLSLLSH 239 E + GA + N + N + +++ ++G D+++E + LS L ++ Sbjct: 201 RIPERLERAASLGAIPI-NAEQENPVRRVRSETNDEGPDLVLEAVGGAATLSLALEMVRP 259 Query: 240 GGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKP-- 297 GGRV VG ++ P S ++ F Y A+ A + G L+P Sbjct: 260 GGRVSAVG----VDNAPSFPFPLASGLVKDLTFRIGLANVHLYIDAVLALLASGRLQPER 315 Query: 298 VIGSQYPLEKVAEAHE 313 ++ PLE+ +E Sbjct: 316 IVSHYLPLEEAPRGYE 331 >4OH1-A nrPDB Length = 351 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 68/283 (24%), Positives = 120/283 (42%), Gaps = 36/283 (12%) Query: 5 QKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTY----- 59 Q + ++R FE + + + +P PKD ++ IKV + +T+I +G Sbjct: 4 QLFVTSIRDFEKNTMGTVDMM-EAPMPEPKDEEIRIKVVYASICGSDTHILTGNLGEMES 62 Query: 60 SRKPLLPYTPGSDVAGVIEAVGDNAS--AFKKGDRVFTS-------------------ST 98 + + +LP + G +++GVI+ VG A FK G +V + S Sbjct: 63 TTRSMLPMSFGHELSGVIDKVGSTAEKMGFKVGQKVVANYAKYCGCCENCREGKVNLCSN 122 Query: 99 IS---GGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVH 155 + G++EYA+ ++ +P+ D K A + T + A + G+SV + Sbjct: 123 MGYRMNGFSEYAVYHMSQIFPIPDDADLKDYAL--VEPLTVALSSAEQAKISYGKSVAIM 180 Query: 156 GASGGVGLAACQIARAYGLKILGTAG-TEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVG 214 GA GG+G+ Q+AR G + E ++ L+NGA N E ++ + G Sbjct: 181 GA-GGLGMMLVQLARLAGASTITVFDIVPEKLELALENGADYALNSAEEGVAERAIELAG 239 Query: 215 EKGIDIIIEMLANVNLSK-DLSLLSHGGRVIVVGSRGTIEINP 256 + D ++E +K L LL+ G + G I P Sbjct: 240 GR-YDCVLEGTGATAAAKLGLQLLARDGDAVYFAMYGKDPILP 281 >2DFV-A nrPDB Length = 347 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 85/339 (25%), Positives = 149/339 (43%), Gaps = 48/339 (14%) Query: 27 DIAVPIPKDHQVLIKVHACGVNPVETYI---RSGTYSR-KPLLPYTPGSDVAGVIEAVGD 82 ++ VP P +VLIKV A + + +I SR KP P G +VAG + +G Sbjct: 20 EVDVPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIKP--PQIMGHEVAGEVVEIGP 77 Query: 83 NASAFKKGDRVFTSSTI--------------------------SGGYAEYALAADHTVYK 116 + GD V + I G +AEYA+ ++K Sbjct: 78 GVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNIWK 137 Query: 117 LPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYG-LK 175 P+ + + A + P A ++ +G+SVL+ GA G +GL +A+A G Sbjct: 138 NPKSIP-PEYATLQEPLGNAVDTVLAGPI--SGKSVLITGA-GPLGLLGIAVAKASGAYP 193 Query: 176 ILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEML-ANVNLSKDL 234 ++ + ++ +++ + GA V N E + + ++ G+D+ +E A L + L Sbjct: 194 VIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGL 253 Query: 235 SLLSHGGRVIVVG---SRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGME 291 ++ GRV ++G + TI+ N + K +I G+T E + + LQ+G Sbjct: 254 QAVTPAGRVSLLGLYPGKVTIDFN-NLIIFKALTIYGIT-GRHLWETWYTVSRLLQSGKL 311 Query: 292 IGWLKPVIGSQYP-LEKVAEAHENIIHGSGATGKMILLL 329 L P+I +Y +K EA E + +G TGK++ +L Sbjct: 312 N--LDPIITHKYKGFDKYEEAFE--LMRAGKTGKVVFML 346 >1PL8-A nrPDB Length = 356 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 84/339 (24%), Positives = 140/339 (41%), Gaps = 47/339 (13%) Query: 18 GPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVET----YIRSGTYSRKPLLPYTPGSDV 73 GP L+L + +P P ++VL+++H+ G+ + Y R G + K P G + Sbjct: 15 GPGDLRLE-NYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKK--PMVLGHEA 71 Query: 74 AGVIEAVGDNASAFKKGDRV-------------------------FTSSTI--SGGYAEY 106 +G +E VG + K GDRV F +T G + Sbjct: 72 SGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRF 131 Query: 107 ALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAAC 166 YKLP+ + F++GA I P A V G VLV GA G +G+ Sbjct: 132 YKHNAAFCYKLPDNVTFEEGALIE-PLSVGIHACRRGG-VTLGHKVLVCGA-GPIGMVTL 188 Query: 167 QIARAYGL-KILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGI--DIIIE 223 +A+A G +++ T + + GA V + + + +K G+ G ++ IE Sbjct: 189 LVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIE 248 Query: 224 ML-ANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMA-KESSIIGVTLFSSTKEEFQQ 281 A ++ + GG +++VG + P A +E I GV + +T Sbjct: 249 CTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNT----WP 304 Query: 282 YAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSG 320 A ++ A + +KP++ ++PLEK EA E G G Sbjct: 305 VAISMLASKSVN-VKPLVTHRFPLEKALEAFETFKKGLG 342 >5YAT-A nrPDB Length = 350 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 65/217 (29%), Positives = 100/217 (46%), Gaps = 39/217 (17%) Query: 13 VFEF-GGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTY---SRKPLLPYT 68 +FE GGP K DI VP PK +++LI V GV + + G + ++ PL+ Sbjct: 13 IFETNGGPLEYK---DIPVPKPKSNELLINVKYSGVCHTDLHAWKGDWPLDNKLPLVGGH 69 Query: 69 PGSDVAGVIEAVGDNASAFKKGDRV---------------------------FTSSTISG 101 G AGV+ A G+N + ++ GD + T G Sbjct: 70 EG---AGVVVAYGENVTGWEIGDYAGIKWLNGSCLNCEYCIQGAESSCAKADLSGFTHDG 126 Query: 102 GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGV 161 + +YA A ++P++ D + A I T Y+AL +A ++ G+ V + GA GG+ Sbjct: 127 SFQQYATADATQAARIPKEADLAEVAPILCAGITVYKAL-KTADLRIGQWVAISGAGGGL 185 Query: 162 GLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVF 198 G A Q A+A GL++LG G + + V GA EVF Sbjct: 186 GSLAVQYAKALGLRVLGIDGGADKGEFVKSLGA-EVF 221 >1HSO-A nrPDB Length = 374 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 78/357 (21%), Positives = 144/357 (40%), Gaps = 61/357 (17%) Query: 27 DIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASA 86 ++ V PK H+V IK+ A G+ + ++ SGT LP G + AG++E+VG+ + Sbjct: 25 EVEVAPPKAHEVRIKMVAVGICGTDDHVVSGTMVTP--LPVILGHEAAGIVESVGEGVTT 82 Query: 87 FKKGDRVF----------------------------TSSTISGG---------------- 102 K GD+V T+ G Sbjct: 83 VKPGDKVIPLAIPQCGKCRICKNPESNYCLKNDVSNPQGTLQDGTSRFTCRRKPIHHFLG 142 Query: 103 ---YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASG 159 +++Y + ++ V K+ ++ IG + T Y + ++ A V G + V G G Sbjct: 143 ISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGL-G 201 Query: 160 GVGLAACQIARAYG-LKILGTAGTEEGQKIVLQNGAHEVFNHREVNY-IDKIKKYVGEKG 217 GVGL+A +A G +I+ ++ + GA E N ++ I ++ K + + G Sbjct: 202 GVGLSAIMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGG 261 Query: 218 IDIIIEMLANVNLSKDLSLLSH--GGRVIVVG---SRGTIEINPRDTMAKESSIIGVTLF 272 +D E++ ++ L H G ++VG + +NP + + + Sbjct: 262 VDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSMNPMLLLTGRTWKGAILGG 321 Query: 273 SSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 +KE + A A + L +I P EK+ E + ++H SG + + IL+ Sbjct: 322 FKSKECVPKLVADFMA--KKFSLDALITHVLPFEKINEGFD-LLH-SGKSIRTILMF 374 >1HSZ-A nrPDB Length = 374 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 78/355 (21%), Positives = 142/355 (40%), Gaps = 61/355 (17%) Query: 27 DIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASA 86 D+ V PK ++V IK+ A G+ + ++ SG LP G + AG++E+VG+ + Sbjct: 25 DVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTP--LPVILGHEAAGIVESVGEGVTT 82 Query: 87 FKKGDRVFTSSTISGG-------------------------------------------- 102 K GD+V T G Sbjct: 83 VKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLG 142 Query: 103 ---YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASG 159 +++Y + ++ V K+ ++ IG + T Y + ++ A V G + V G G Sbjct: 143 TSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGL-G 201 Query: 160 GVGLAACQIARAYG-LKILGTAGTEEGQKIVLQNGAHEVFNHREVNY-IDKIKKYVGEKG 217 GVGL+A +A G +I+ ++ + GA E N ++ I ++ K + + G Sbjct: 202 GVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGG 261 Query: 218 IDIIIEMLANVNLSKDLSLLSH--GGRVIVVG---SRGTIEINPRDTMAKESSIIGVTLF 272 +D E++ ++ L H G ++VG + + INP + + V Sbjct: 262 VDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGG 321 Query: 273 SSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 +KE + A A + L +I P EK+ E + ++H SG + + +L Sbjct: 322 FKSKEGIPKLVADFMA--KKFSLDALITHVLPFEKINEGFD-LLH-SGKSIRTVL 372 >2H6E-A nrPDB Length = 344 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 75/326 (23%), Positives = 134/326 (41%), Gaps = 45/326 (13%) Query: 27 DIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPL-LPYTPGSDVAGVIEAVGDNAS 85 D+ +P P+ +VLI++ GV + + G +++ LP G + AG I VG+ A Sbjct: 20 DVNIPEPQGEEVLIRIGGAGVCRTDLRVWKGVEAKQGFRLPIILGHENAGTIVEVGELAK 79 Query: 86 AFKKGDRVFT--------------------------SSTISGGYAEYALAADHTVYKLPE 119 KKGD V T +GG++EY L Sbjct: 80 V-KKGDNVVVYATWGDLTCRYCREGKFNICKNQIIPGQTTNGGFSEYMLVKSSRWLVKLN 138 Query: 120 KLDFKQGAAIGIPYFTAYRALIHSA--CVKAGESVLVHGASGGVGLAACQIARAY--GLK 175 L + A + T+ A+ + K E V++ GG+ + QI +A + Sbjct: 139 SLSPVEAAPLADAGTTSMGAIRQALPFISKFAEPVVIVNGIGGLAVYTIQILKALMKNIT 198 Query: 176 ILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDL- 234 I+G + +++ + L+ GA V ++ + I K G I I+++ + +L Sbjct: 199 IVGISRSKKHRDFALELGADYVSEMKDAESL--INKLTDGLGASIAIDLVGTEETTYNLG 256 Query: 235 SLLSHGGRVIVVGSRGT-IEINPRDTMAKESSIIGVTLFS-STKEEFQQYAAALQAGMEI 292 LL+ G +I+VG G + + DT ++G S + E+ + + E Sbjct: 257 KLLAQEGAIILVGMEGKRVSLEAFDTAVWNKKLLGSNYGSLNDLEDVVRLS-------ES 309 Query: 293 GWLKPVIGSQYPLEKVAEAHENIIHG 318 G +KP I + PL+ + +A N+ G Sbjct: 310 GKIKPYI-IKVPLDDINKAFTNLDEG 334 >1U3W-A nrPDB Length = 374 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 76/346 (21%), Positives = 136/346 (39%), Gaps = 59/346 (17%) Query: 27 DIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASA 86 ++ V PK H+V IK+ A G+ + ++ SG LP G + AG++E+VG+ + Sbjct: 25 EVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLVTP--LPVILGHEAAGIVESVGEGVTT 82 Query: 87 FKKGDRV---FTSS----------------------------------TISG-------- 101 K GD+V FT T SG Sbjct: 83 VKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVG 142 Query: 102 --GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASG 159 +++Y + ++ V K+ ++ IG + T Y + + A V G + V G G Sbjct: 143 VSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGL-G 201 Query: 160 GVGLAACQIARAYG-LKILGTAGTEEGQKIVLQNGAHEVFNHREVNY-IDKIKKYVGEKG 217 GVGL+ +A G +I+ ++ + GA E N ++ I ++ K + + G Sbjct: 202 GVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGG 261 Query: 218 IDIIIEMLANVNLSKDLSLLSH--GGRVIVVG---SRGTIEINPRDTMAKESSIIGVTLF 272 +D E++ ++ L H G ++VG + INP + + + Sbjct: 262 VDFSFEVIGQLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGG 321 Query: 273 SSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHG 318 +KE + A A + L +I + P EK+ E + + G Sbjct: 322 FKSKESVPKLVADFMA--KKFSLDALITNVLPFEKINEGFDLLRSG 365 >1MC5-A nrPDB Length = 374 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 69/284 (24%), Positives = 115/284 (40%), Gaps = 58/284 (20%) Query: 9 RAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYT 68 +A +E G P ++ +I V PK H+V IK+ A V + Y SG + P Sbjct: 9 KAAVAWEAGKPLSIE---EIEVAPPKAHEVRIKIIATAVCHTDAYTLSGA-DPEGCFPVI 64 Query: 69 PGSDVAGVIEAVGDNASAFKKGDRV----------------------------------- 93 G + AG++E+VG+ + K GD V Sbjct: 65 LGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMP 124 Query: 94 -----FTSS--TI-----SGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALI 141 FT TI + ++EY + AD +V K+ + +G T Y A + Sbjct: 125 DGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAV 184 Query: 142 HSACVKAGESVLVHGASGGVGLA---ACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVF 198 ++A ++ G V G GGVGLA C++A A +I+G ++ + GA E Sbjct: 185 NTAKLEPGSVCAVFGL-GGVGLAVIMGCKVAGAS--RIIGVDINKDKFARAKEFGATECI 241 Query: 199 NHREVNY-IDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGG 241 N ++ + I ++ + + G+D E + NV + + H G Sbjct: 242 NPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKG 285 >5LB9-A nrPDB Length = 385 Score = 50.8 bits (120), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 44/157 (28%), Positives = 62/157 (39%), Gaps = 23/157 (14%) Query: 36 HQVLIKVHACGVNPVETYIRSGTYSRKP--------LLPYTPGSDVAGVIEA--VGDNAS 85 ++V++K VNP + G Y KP P P + G+ E VG N S Sbjct: 55 NEVIVKTLGSPVNPSDINQIQGVYPSKPAKTTGFGTTEPAAPCGN-EGLFEVIKVGSNVS 113 Query: 86 AFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEK-----------LDFKQGAAIGIPYF 134 + + GD V S G + +AL D KLP L QGA I + Sbjct: 114 SLEAGDWVIPSHVNFGTWRTHALGNDDDFIKLPNPAQSKANGKPNGLTINQGATISVNPL 173 Query: 135 TAYRALIHSACVKAGESVLV-HGASGGVGLAACQIAR 170 AY L H + G+ + +G + VG A QI + Sbjct: 174 VAYLMLTHYVKLTPGKDWFIQNGGTSAVGKYASQIGK 210 >1E3E-A nrPDB Length = 376 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 66/296 (22%), Positives = 119/296 (40%), Gaps = 66/296 (22%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67 +A ++ G P ++ +I V PK +V I+V A V P T I + +K L P Sbjct: 9 CKAAIAWKTGSPLCIE---EIEVSPPKACEVRIQVIATCVCP--TDINATDPKKKALFPV 63 Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRV---------------------------FTSSTIS 100 G + AG++E+VG + FK GD+V F TI Sbjct: 64 VLGHECAGIVESVGPGVTNFKPGDKVIPFFAPQCKRCKLCLSPLTNLCGKLRNFKYPTID 123 Query: 101 ------------------------GGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTA 136 +++Y + ++ + ++ ++ + ++ IG + + Sbjct: 124 QELMEDRTSRFTCKGRSIYHFMGVSSFSQYTVVSEANLARVDDEANLERVCLIGCGFSSG 183 Query: 137 YRALIHSACVKAGESVLVHGASGGVGLAA---CQIARAYGLKILGTAGTEEGQKIVLQNG 193 Y A I++A V G + V G G VGL+A C+IA A + + G + + L G Sbjct: 184 YGAAINTAKVTPGSTCAVFGL-GCVGLSAIIGCKIAGASRIIAIDINGEKFPKAKAL--G 240 Query: 194 AHEVFNHREVNY-IDKIKKYVGEKGIDIIIEMLANVNLSK---DLSLLSHGGRVIV 245 A + N RE++ + + + G+D ++ K D ++L G +V Sbjct: 241 ATDCLNPRELDKPVQDVITELTAGGVDYSLDCAGTAQTLKAAVDCTVLGWGSCTVV 296 >4ILK-A nrPDB Length = 359 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 75/316 (23%), Positives = 138/316 (43%), Gaps = 49/316 (15%) Query: 30 VPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKK 89 +P P +V +KV G+ +++I G ++ P G + GVI+AVG+ + + Sbjct: 39 IPTPSAGEVRVKVKLAGICGSDSHIYRG-HNPFAKYPRVIGHEFFGVIDAVGEGVESARV 97 Query: 90 GDRVFTSSTIS--------------------------GGYAEYALAADHTVYKLPEKLDF 123 G+RV +S GG++EYA+ +K+PE + Sbjct: 98 GERVAVDPVVSCGHCYPCSIGKPNVCTTLAVLGVHADGGFSEYAVVPAKNAWKIPEAVA- 156 Query: 124 KQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIAR-AYGLK-ILGTAG 181 Q A + P+ A H + ++VLV+GA G +GL Q+ + Y +K ++ Sbjct: 157 DQYAVMIEPFTIAANVTGHGQPTE-NDTVLVYGA-GPIGLTIVQVLKGVYNVKNVIVADR 214 Query: 182 TEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGID--IIIEMLANVNLSKD-LSLLS 238 +E + ++GA N+ + + + EKGI +II+ + ++ K+ ++L S Sbjct: 215 IDERLEKAKESGADWAINNSQT----PLGESFAEKGIKPTLIIDAACHPSILKEAVTLAS 270 Query: 239 HGGRVIVVG-SRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKP 297 R++++G S E+ + KE SI L +F L G+ +KP Sbjct: 271 PAARIVLMGFSSEPSEVIQQGITGKELSIFSSRL---NANKFPVVIDWLSKGL----IKP 323 Query: 298 --VIGSQYPLEKVAEA 311 +I + + VA+A Sbjct: 324 EKLITHTFDFQHVADA 339 >4OAQ-A nrPDB Length = 367 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 67/285 (23%), Positives = 114/285 (40%), Gaps = 49/285 (17%) Query: 36 HQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRV-- 93 H V++K CG+ + + S + G ++ G + AVGD + FK GDRV Sbjct: 36 HDVVLKNEVCGLCYSDIHTLSAGWQPLQRDNLVVGHEIIGEVIAVGDEVTEFKVGDRVGI 95 Query: 94 ---------------------------FTSSTI-------SGGYAEYALAADHTVYKLPE 119 + S + GGY+ +++A + V+ +PE Sbjct: 96 GAASSSCRSCQRCDSDNEQYCKQGAATYNSKDVRSNNYVTQGGYSSHSIADEKFVFAIPE 155 Query: 120 KLDFKQGAAIGIPYFTAYRALIHSACVKA-GESVLVHGASGGVGLAACQIARAYGLKILG 178 L GA + T + LI + + A G++V + G G LA Q A A G + Sbjct: 156 DLPSSYGAPLMCAGITVFSPLIRNLGLDARGKNVGIIGIGGLGHLAL-QFANAMGANVTA 214 Query: 179 TAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANV---NLSKDLS 235 + + ++ ++ GAH+ E DK + D I+ + + NLS+ LS Sbjct: 215 FSRSSSKKEQAMKLGAHDFVATGE----DKTWYKNYDDHFDFILNCASGIDGLNLSEYLS 270 Query: 236 LLSHGGRVIVVG---SRGTIEINPRDTMAKESSIIGVTLFSSTKE 277 L + + VG S E++P T ++ + G +L S E Sbjct: 271 TLKVDKKFVSVGLPPSEDKFEVSPF-TFLQQGASFGSSLLGSKTE 314 >5H82-A nrPDB Length = 389 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 44/189 (23%), Positives = 69/189 (36%), Gaps = 49/189 (25%) Query: 35 DHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRV- 93 +H V KV CG+ + TY P+ PG ++ G++ +G+ FK GD+V Sbjct: 53 EHDVQFKVLYCGLCDWDVITTKNTYGTTKY-PFVPGHEIMGIVTEIGNKVKKFKVGDKVG 111 Query: 94 --------------------------FTSST--------------------ISGGYAEYA 107 +T T I GGY+ Sbjct: 112 VGNFIGSCGKCERCNEGLEPYCPKVIYTDGTAFSDENNTVYGDVSGDGEDRIYGGYSNIM 171 Query: 108 LAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQ 167 +A ++ V++ PE L G I Y + H K G S+ V G G +G A + Sbjct: 172 VANEYVVFRWPENLPLAAGVPILCGGIVPYSPMRHFGLDKPGLSIGVVGF-GRIGKLAVK 230 Query: 168 IARAYGLKI 176 A+A+G + Sbjct: 231 FAKAFGANV 239 >3GFB-A nrPDB Length = 350 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 84/338 (24%), Positives = 143/338 (42%), Gaps = 48/338 (14%) Query: 27 DIAVPIPKDHQVLIKVHACGVNPVETYI---RSGTYSR-KPLLPYTPGSDVAGVIEAVGD 82 ++ VP P +VLIKV A + + +I SR KP P G +VAG + VG Sbjct: 21 EVDVPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIKP--PQIMGHEVAGEVVEVGP 78 Query: 83 NASAFKKGDRVFTSSTI--------------------------SGGYAEYALAADHTVYK 116 + GD + + I G +A YA+ +K Sbjct: 79 GVEDLQVGDYISVETHIVCGKCYACKHNRYHVCQNTKIFGVDMDGVFAHYAIVPAKNAWK 138 Query: 117 LPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYG-LK 175 P+ + + AA+ P A ++ AG S L+ GA G +GL +A+A G Sbjct: 139 NPKDMP-PEYAALQEPLGNAVDTVLAGPI--AGRSTLITGA-GPLGLLGIAVAKASGAYP 194 Query: 176 ILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEML-ANVNLSKDL 234 ++ + +E +K+ + GA V N E + + + G+++ +E A L + L Sbjct: 195 VIVSEPSEFRRKLAKKVGADYVVNPFEEDPVKFVMDITDGAGVEVFLEFSGAPKALEQGL 254 Query: 235 SLLSHGGRVIVVG---SRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGME 291 ++ GGRV ++G TI+ N + K + G+T E + ++ +Q+G Sbjct: 255 KAVTPGGRVSLLGLFPREVTIDFN-NLIIFKALEVHGIT-GRHLWETWYTVSSLIQSGKL 312 Query: 292 IGWLKPVIGSQYP-LEKVAEAHENIIHGSGATGKMILL 328 L P+I +Y +K EA E + +G TGK++ Sbjct: 313 N--LDPIITHKYKGFDKFEEAFE--LMRAGKTGKVVFF 346 >1F8F-A nrPDB Length = 371 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 71/313 (22%), Positives = 126/313 (40%), Gaps = 63/313 (20%) Query: 20 EVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEA 79 + LK+R P+ +VL+KV A G+ + +R Y LP G + +G+IEA Sbjct: 22 QALKIRQ------PQGDEVLVKVVATGMCHTDLIVRDQKYPVP--LPAVLGHEGSGIIEA 73 Query: 80 VGDNASAFKKGDRV-----------------------FTSSTISGG-------------- 102 +G N + + GD V F SG Sbjct: 74 IGPNVTELQVGDHVVLSYGYCGKCTQCNTGNPAYCSEFFGRNFSGADSEGNHALCTHDQG 133 Query: 103 -----------YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGES 151 +A YAL+ ++ K+ + + + +G T A I++ V S Sbjct: 134 VVNDHFFAQSSFATYALSRENNTVKVTKDVPIELLGPLGCGIQTGAGACINALKVTPASS 193 Query: 152 VLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQ-KIVLQNGAHEVFNHREVNYIDKIK 210 + GA G VGL+A A+ G I+ E + ++ Q GA V N + + + IK Sbjct: 194 FVTWGA-GAVGLSALLAAKVCGASIIIAVDIVESRLELAKQLGATHVINSKTQDPVAAIK 252 Query: 211 KYVGEKGIDIIIEMLANVN-LSKDLSLLSHGGRVIVVGSR---GTIEINPRDTMAKESSI 266 + + + G++ +E + L + + L G++ VVG+ T + + D + +I Sbjct: 253 E-ITDGGVNFALESTGSPEILKQGVDALGILGKIAVVGAPQLGTTAQFDVNDLLLGGKTI 311 Query: 267 IGVTLFSSTKEEF 279 +GV S + ++F Sbjct: 312 LGVVEGSGSPKKF 324 >1E3J-A nrPDB Length = 352 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 71/322 (22%), Positives = 133/322 (41%), Gaps = 49/322 (15%) Query: 30 VPIPKDHQVLIKVHACGVNPVETYI----RSGTYSRKPLLPYTPGSDVAGVIEAVGDNAS 85 +P PK+ +VL+++ G+ + + R + K P G + +G + VG N Sbjct: 23 IPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKD--PMVIGHEASGTVVKVGKNVK 80 Query: 86 AFKKGDRVFTSSTI---------------------------SGGYAEYALAADHTVYKLP 118 KKGDRV + G A Y + A +KLP Sbjct: 81 HLKKGDRVAVEPGVPCRRCQFCKEGKYNLCPDLTFCATPPDDGNLARYYVHAADFCHKLP 140 Query: 119 EKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILG 178 + + ++GA + P A A V+ G +VLV GA G +GL + A+AYG ++ Sbjct: 141 DNVSLEEGALLE-PLSVGVHAC-RRAGVQLGTTVLVIGA-GPIGLVSVLAAKAYGAFVVC 197 Query: 179 TAGTEEGQKIVLQNGAHEVF-----NHREVNYIDKIKKYVGEKGIDIIIEMLANVN-LSK 232 TA + ++ GA E + I++I+ +G+ ++ I+ N ++ Sbjct: 198 TARSPRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAIGDLP-NVTIDCSGNEKCITI 256 Query: 233 DLSLLSHGGRVIVVGSRGTIEINPR-DTMAKESSIIGVTLFSSTKEEFQQYAAALQAGME 291 +++ GG +++VG + P + A+E I V + + + A+ + Sbjct: 257 GINITRTGGTLMLVGMGSQMVTVPLVNACAREIDIKSVFRYCNDYPIALEMVASGRCN-- 314 Query: 292 IGWLKPVIGSQYPLEKVAEAHE 313 +K ++ + LE+ +A E Sbjct: 315 ---VKQLVTHSFKLEQTVDAFE 333 >3QE3-A nrPDB Length = 355 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 85/340 (25%), Positives = 138/340 (40%), Gaps = 49/340 (14%) Query: 18 GPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYI----RSGTYSRKPLLPYTPGSDV 73 GP L+L + +P P ++VL+K+H+ G+ + + R G + K P G + Sbjct: 14 GPGDLRLE-NYPIPEPGPNEVLLKMHSVGICGSDVHYWQHGRIGDFVVKK--PMVLGHEA 70 Query: 74 AGVIEAVGDNASAFKKGDRVFT-------------------SSTI--------SGGYAEY 106 +G + VG + GDRV S TI G + Sbjct: 71 SGTVVKVGSLVRHLQPGDRVAIQPGAPRQTDEFCKIGRYNLSPTIFFCATPPDDGNLCRF 130 Query: 107 ALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAAC 166 + YKLP+ + F++GA I P A A V G VLV GA G +GL Sbjct: 131 YKHNANFCYKLPDNVTFEEGALIE-PLSVGIHA-CRRAGVTLGNKVLVCGA-GPIGLVNL 187 Query: 167 QIARAYGL-KILGTAGTEEGQKIVLQNGAH---EVFNHREVNYIDKIKKYVGEKGIDIII 222 A+A G +++ T + + GA E+ N K++ +G K ++ I Sbjct: 188 LAAKAMGAAQVVVTDLSASRLSKAKEVGADFILEISNESPEEIAKKVEGLLGSKP-EVTI 246 Query: 223 EML-ANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMA-KESSIIGVTLFSSTKEEFQ 280 E ++ + GG +++VG + P A +E I GV + +T Sbjct: 247 ECTGVETSIQAGIYATHSGGTLVLVGLGSEMTSVPLVHAATREVDIKGVFRYCNT----W 302 Query: 281 QYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSG 320 A ++ A + +KP++ ++PLEK EA E G G Sbjct: 303 PMAISMLASKSVN-VKPLVTHRFPLEKALEAFETSKKGLG 341 >1P0F-A nrPDB Length = 373 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 61/252 (24%), Positives = 97/252 (38%), Gaps = 57/252 (22%) Query: 28 IAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAF 87 I V PK H+V IK+ A G+ ++ + K P G + GV+E++G + Sbjct: 27 ITVAPPKAHEVRIKILASGICGSDSSVLKEIIPSK--FPVILGHEAVGVVESIGAGVTCV 84 Query: 88 KKGDRV------------------------------------FTSSTISGG--------- 102 K GD+V TS G Sbjct: 85 KPGDKVIPLFVPQCGSCRACKSSNSNFCEKNDMGAKTGLMADMTSRFTCRGKPIYNLMGT 144 Query: 103 --YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGG 160 + EY + AD V K+ K + IG + T Y A +++A V G + V G GG Sbjct: 145 STFTEYTVVADIAVAKIDPKAPL-ESCLIGCGFATGYGAAVNTAKVTPGSTCAVFGL-GG 202 Query: 161 VGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEK--- 216 VG +A +A G +I+G ++ ++ GA E N ++ Y I + + EK Sbjct: 203 VGFSAIVGCKAAGASRIIGVGTHKDKFPKAIELGATECLNPKD--YDKPIYEVICEKTNG 260 Query: 217 GIDIIIEMLANV 228 G+D +E + Sbjct: 261 GVDYAVECAGRI 272 >4UEJ-A nrPDB Length = 346 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 78/302 (25%), Positives = 126/302 (41%), Gaps = 49/302 (16%) Query: 66 PYTPGSDVAGVIEAVGDNASAFKKGDRV--------------------------FTSSTI 99 P T G + +G I+AVG GD V F S Sbjct: 54 PITLGHEFSGYIDAVGSGVDDLHPGDAVACVPLLPCFTCPECLKGFYSQCAKYDFIGSRR 113 Query: 100 SGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASG 159 GG+AEY + V+ LP + + GA I P A H A ++V++ GA G Sbjct: 114 DGGFAEYIVVKRKNVFALPTDMPIEDGAFIE-PITVGLHAF-HLAQGCENKNVIIIGA-G 170 Query: 160 GVGLAACQIARAYGLKILGTAGTEEGQKIVLQN--GAHEVFNHREVNYIDKIKKYVGEKG 217 +GL A Q A A G K + TA +K+ L GA + FN E++ +++ + E Sbjct: 171 TIGLLAIQCAVALGAKSV-TAIDISSEKLALAKSFGAMQTFNSSEMS-APQMQSVLRELR 228 Query: 218 IDIIIEMLANVNLSKDLSLL---SHGGRVIVVGSRGTIEINPRDTMA-------KESSII 267 + +I A V + +L++ H +V GT+ + T A KE ++I Sbjct: 229 FNQLILETAGVPQTVELAVEIAGPHAQLALV----GTLHQDLHLTSATFGKILRKELTVI 284 Query: 268 GVTLFSSTKEEFQQYAAALQAGMEIGW-LKPVIGSQYPLEKVAEAHENIIHGSGATGKMI 326 G + S+ Q++ A + E L+P+I + E A+A +I + GK++ Sbjct: 285 GSWMNYSSPWPGQEWETASRLLTERKLSLEPLIAHRGSFESFAQAVRDIAR-NAMPGKVL 343 Query: 327 LL 328 L+ Sbjct: 344 LI 345 >1EE2-A nrPDB Length = 373 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 71/345 (20%), Positives = 136/345 (39%), Gaps = 58/345 (16%) Query: 27 DIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASA 86 ++ V PK H+V IK+ A G+ + ++ SGT LP G + AG++E++G+ + Sbjct: 25 EVEVAPPKAHEVRIKMVAAGICRSDDHVVSGTLVAP--LPVIAGHEAAGIVESIGEGVTT 82 Query: 87 FKKGDRVF-----------------------------------TSSTISGG--------- 102 + GD+V TS G Sbjct: 83 VRPGDKVIPLFIPQCGKCSVCKHPEGNLCLKNLSMPRGTMQDGTSRFTCRGKPIHHFLGT 142 Query: 103 --YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGG 160 +++Y + + +V K+ ++ +G + T Y + + A V G + V G GG Sbjct: 143 STFSQYTVVDEISVAKIDAASPLEKVCLVGCGFSTGYGSAVKVAKVTQGSTCAVFGL-GG 201 Query: 161 VGLAACQIARAYG-LKILGTAGTEEGQKIVLQNGAHEVFNHREVNY-IDKIKKYVGEKGI 218 VGL+ +A G +I+G ++ + GA E N ++ I ++ + G+ Sbjct: 202 VGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGV 261 Query: 219 DIIIEMLANVN-LSKDLSLLSHG-GRVIVVG---SRGTIEINPRDTMAKESSIIGVTLFS 273 D E++ ++ + LS G ++VG + +NP ++ + + Sbjct: 262 DFSFEVIGRLDTMVAALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGF 321 Query: 274 STKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHG 318 +K+ + A A + L P+I P EK+ E + + G Sbjct: 322 KSKDSVPKLVADFMA--KKFALDPLITHVLPFEKINEGFDLLRSG 364 >1D1T-A nrPDB Length = 373 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 49/223 (21%), Positives = 90/223 (40%), Gaps = 50/223 (22%) Query: 27 DIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASA 86 +I V PK +V IK+ A G+ + ++ GT K P G + G++E++G+ + Sbjct: 25 EIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVSK--FPVIVGHEATGIVESIGEGVTT 82 Query: 87 FKKGDRVF---------------------TSSTISG------------------------ 101 K GD+V S I+G Sbjct: 83 VKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLADGTTRFTCKGKPVHHFLNT 142 Query: 102 -GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGG 160 + EY + + +V K+ + ++ IG + T Y A + + VK G + +V G GG Sbjct: 143 STFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGL-GG 201 Query: 161 VGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEVFNHRE 202 VGL+ ++ G +I+G ++ + + GA E + ++ Sbjct: 202 VGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECISPKD 244 >5YLN-A nrPDB Length = 356 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 52/181 (28%), Positives = 74/181 (40%), Gaps = 33/181 (18%) Query: 75 GVIEAVGDNASAFKKGDRVFTSST----------------------------ISGGYAEY 106 G++E VG+ S FKKGD+V S I G AEY Sbjct: 68 GIVEEVGEGVSNFKKGDKVLISCVCACGKCYYCKKGIYAHCEDEGGWIFGHLIDGMQAEY 127 Query: 107 ALA--ADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLA 164 AD+T+Y PE L + + T Y + V+ G SV + G SG VGLA Sbjct: 128 LRVPHADNTLYHTPEDLSDEALVMLSDILPTGYEIGVLKGKVEPGCSVAIIG-SGPVGLA 186 Query: 165 ACQIARAYGLKILGTAGTEEGQ-KIVLQNGA-HEVFNHREVNYIDKIKKYVGEKGIDIII 222 A A+ Y L ++ + + L GA H+V + I +I +G+D+ I Sbjct: 187 ALLTAQFYSPAKLIMVDLDDNRLETALSFGATHKVNSSDPEKAIKEIYDLTDGRGVDVAI 246 Query: 223 E 223 E Sbjct: 247 E 247 >3WLE-A nrPDB Length = 341 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 91/215 (42%), Gaps = 35/215 (16%) Query: 14 FEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETY-IRSGTYSRKPLLPYTPGSD 72 F F LKLR+D+ V PK Q+L+KV A G+ + + I G Y G + Sbjct: 15 FVFNKQSGLKLRNDLPVHKPKAGQLLLKVDAVGLCHSDLHVIYEGLDCGDN---YVMGHE 71 Query: 73 VAGVIEAVGDNASAFKKGDRV------------FTSSTIS----------------GGYA 104 +AG + AVGD+ +K GDRV + I GGY Sbjct: 72 IAGTVAAVGDDVINYKVGDRVACVGPNGCGGCKYCRGAIDNVCKNAFGDWFGLGYDGGYQ 131 Query: 105 EYALAA-DHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGL 163 +Y L + ++P+ + AA T Y A+ + + S ++ +GG+G Sbjct: 132 QYLLVTRPRNLSRIPDNVSADVAAASTDAVLTPYHAIKMAQV--SPTSNILLIGAGGLGG 189 Query: 164 AACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVF 198 A Q+A+A+G K+ +E + + GA V+ Sbjct: 190 NAIQVAKAFGAKVTVLDKKKEARDQAKKLGADAVY 224 >4RQU-A nrPDB Length = 375 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 26/109 (23%), Positives = 49/109 (44%), Gaps = 4/109 (3%) Query: 9 RAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYT 68 +A +E G P V++ ++ V P+ H+V IK+ + + Y + PL P Sbjct: 7 KAAVAWEAGKPLVIE---EVEVAPPQKHEVRIKILFTSLCHTDVYFWEAK-GQTPLFPRI 62 Query: 69 PGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKL 117 G + G++E+VG+ + + GD V T G + + + + L Sbjct: 63 FGHEAGGIVESVGEGVTDLQPGDHVLPIFTGECGECRHCHSEESNMCDL 111 >5VKT-A nrPDB Length = 362 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 42/181 (23%), Positives = 69/181 (38%), Gaps = 38/181 (20%) Query: 32 IPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGD 91 I D V IKV CG+ + ++ + + P PG +V GV+ VG + FK GD Sbjct: 31 IQGDADVTIKVLFCGICHTDLHVIKNEWGNA-MYPVVPGHEVVGVVTDVGHGVTKFKAGD 89 Query: 92 RV----FTSS--------------------------------TISGGYAEYALAADHTVY 115 V F S T GG+++ + + V Sbjct: 90 TVGVGYFVDSCRTCESCSTGHENYCPDLVLTSNGVDHHHHGATTKGGFSDVLVVSQDFVV 149 Query: 116 KLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLK 175 ++PE L A + T Y + A + G+ + V G G +A + A+A+G+ Sbjct: 150 RVPESLPLDGAAPLLCAGVTVYSPMAQYALNEPGKHLGVVGLGGLGHMAV-KFAKAFGMT 208 Query: 176 I 176 + Sbjct: 209 V 209 >4JJI-A nrPDB Length = 378 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 60/286 (20%), Positives = 115/286 (40%), Gaps = 59/286 (20%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKP--LL 65 +A +E P V++ D+ V P+ +V IK+ + + Y SG + P L Sbjct: 9 CKAAVAYEPNKPLVIE---DVQVAPPQAGEVRIKILYTALCHTDAYTWSG---KDPEGLF 62 Query: 66 PYTPGSDVAGVIEAVGDNASAFKKGDRV------------FTSS---------------- 97 P G + AG++E+VG+ + + GD V F S Sbjct: 63 PCILGHEAAGIVESVGEGVTEVQAGDHVIPCYQAECRECKFCKSGKTNLCGKVRSATGVG 122 Query: 98 ----------TISG----------GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAY 137 +++G +++Y + D +V K+ + +G T Sbjct: 123 IMMNDRKSRFSVNGKPIYHFMGTSTFSQYTVVHDVSVAKIDPTAPLDKVCLLGCGVPTGL 182 Query: 138 RALIHSACVKAGESVLVHGASGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHE 196 A+ ++A V+ G +V + G G VGLA + A+ G +I+G + + + G +E Sbjct: 183 GAVWNTAKVEPGSNVAIFGL-GTVGLAVAEGAKTAGASRIIGIDIDSKKYETAKKFGVNE 241 Query: 197 VFNHREVNY-IDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGG 241 N ++ + I ++ + + G+D E + NV++ + H G Sbjct: 242 FVNPKDHDKPIQEVIVDLTDGGVDYSFECIGNVSVMRAALECCHKG 287 >4DLA-A nrPDB Length = 396 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 64/285 (22%), Positives = 112/285 (39%), Gaps = 59/285 (20%) Query: 9 RAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKP--LLP 66 +A +E P V++ D+ V P+ +V +KV + + Y SG + P L P Sbjct: 28 KAAVAWEPNKPLVIE---DVQVAPPQAGEVRVKVLYTALCHTDAYTWSG---KDPEGLFP 81 Query: 67 YTPGSDVAGVIEAVGDNASAFKKGDRV------------FTSS----------------- 97 G + AG++E+VG+ + + GD V F S Sbjct: 82 CVLGHEAAGIVESVGEGVTEVQPGDHVIPCYQAECRECKFCKSGKTNLCGKVRAATGVGV 141 Query: 98 ---------TISG----------GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYR 138 +I+G +++Y + D +V K+ ++ +G T Sbjct: 142 MMNDRKSRFSINGKPIYHFMGTSTFSQYTVVHDVSVAKIDPVAPLEKVCLLGCGVPTGLG 201 Query: 139 ALIHSACVKAGESVLVHGASGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEV 197 A+ ++A V+ G V V G G VGLA + A+A G +I+G + G E Sbjct: 202 AVWNTAKVEPGSIVAVFGL-GTVGLAVAEGAKAAGASRIIGIDIDSKKFDRAKNFGVTEF 260 Query: 198 FNHREVNY-IDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGG 241 N +E I ++ + + G+D E + NV++ + H G Sbjct: 261 INPKEHEQPIQQVIVDLTDGGVDYSFECIGNVSVMRSALECCHKG 305 >4GKV-A nrPDB Length = 336 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 53/244 (21%), Positives = 100/244 (40%), Gaps = 37/244 (15%) Query: 34 KDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRV 93 K + L+K+ CGV + ++++G + K + G + GV+ VG ++ K GDR Sbjct: 23 KHGEALLKMECCGVCHTDLHVKNGDFGDKTGVIL--GHEGIGVVAEVGPGVTSLKPGDRA 80 Query: 94 -------------FTSS--------------TISGGYAEYALAADHTVYKLPEKLDFKQG 126 + +S ++ GG AE + K+P+ LD Sbjct: 81 SVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMAEECIVVADYAVKVPDGLDSAAA 140 Query: 127 AAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQ 186 ++I T Y+A+ S ++ G+ + ++G G LA + K++ +E Sbjct: 141 SSITCAGVTTYKAVKLSK-IRPGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDEQL 199 Query: 187 KIVLQNGAHEVFNHREVNYIDKIKKYVGEK---GIDIIIEMLANVNLSKDLSLLSHGGRV 243 K+ + GA N ++ + K V EK ++ +A + + + GGRV Sbjct: 200 KLATEMGADLAIN----SHTEDAAKIVQEKTGGAHAAVVTAVAKAAFNSAVDAVRAGGRV 255 Query: 244 IVVG 247 + VG Sbjct: 256 VAVG 259 >5Z0C-A nrPDB Length = 374 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 54/248 (21%), Positives = 100/248 (40%), Gaps = 43/248 (17%) Query: 37 QVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRV--- 93 V KV CG+ + + +S + P PG ++ G + VG + FK GD+V Sbjct: 40 DVTFKVLYCGICHSDLHYIKNEWSNT-IYPALPGHEIVGEVTEVGSKVNKFKVGDKVGVG 98 Query: 94 -------------------------------FTSSTISGGYAEYALAADHTVYKLPEKLD 122 + + GGY++ + +H ++P+ L Sbjct: 99 CIVGSCHSCPNCNNHLENYCPNRILTFGSRYYDGTLNHGGYSDLMVVQEHFAVRIPDALP 158 Query: 123 FKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGT 182 A + T Y L + K G V V G G +A + A+A+G+K+ + + Sbjct: 159 LDSAAPLLCAGITVYSPLRYYGLDKPGLHVGVVGLGGLGHMAV-KFAKAFGVKVTVVSTS 217 Query: 183 EEGQKIVLQN-GAHEVFNHREVNYIDKIKKYVGEKGIDIIIEML-ANVNLSKDLSLLSHG 240 ++ + GAH + ++++ VG +D II+ + A+ L +SLL Sbjct: 218 PAKKEDAISGLGAHSFILSTDA---EQMQAAVGT--MDGIIDTVSASHPLPPLISLLKSH 272 Query: 241 GRVIVVGS 248 G++++VG Sbjct: 273 GKLVMVGD 280 >5FI5-A nrPDB Length = 357 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 54/242 (22%), Positives = 96/242 (39%), Gaps = 35/242 (14%) Query: 35 DHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVF 94 +H V +KV CG + + + PY G ++ G + VG FK GD+V Sbjct: 42 EHDVQLKVLYCGTCQYDREMSKNKFGFTSY-PYVLGHEIVGEVTEVGSKVQKFKVGDKVG 100 Query: 95 TSSTIS--------------------------GGYAEYALAADHTVYKLPEKLDFKQGAA 128 +S I G + A+ ++ V + PE L G Sbjct: 101 VASIIETCGKCEMCTNEVENYCPEAGSIDSNYGACSNIAVINENFVIRWPENLPLDSGVP 160 Query: 129 IGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKI 188 + TAY + K G+ + + G G +A + A+A+G K+ + + + ++ Sbjct: 161 LLCAGITAYSPMKRYGLDKPGKRIGIAGLGGLGHVAL-RFAKAFGAKVTVISSSLKKKR- 218 Query: 189 VLQNGAHEVFNHREVNYIDKIKKYVGEKG-IDIIIEML-ANVNLSKDLSLLSHGGRVIVV 246 A E F ++ G G +D II+ + N +L L+LL G++I++ Sbjct: 219 ----EAFEKFGADSFLVSSNPEEMQGAAGTLDGIIDTIPGNHSLEPLLALLKPLGKLIIL 274 Query: 247 GS 248 G+ Sbjct: 275 GA 276 >3RSH-A nrPDB Length = 251 Score = 36.6 bits (83), Expect = 0.015, Method: Compositional matrix adjust. Identities = 27/95 (28%), Positives = 48/95 (50%), Gaps = 9/95 (9%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVL----QNGAHEVFNHREVN 204 G+ LV GAS G+G A ++ G K++GTA +E G + + NG N Sbjct: 12 GKVALVTGASRGIGKAIAELLAERGAKVIGTATSESGAQAISDYLGDNGKGMALNVTNPE 71 Query: 205 YIDKIKKYVGEK--GIDIIIEMLANVNLSKDLSLL 237 I+ + K + ++ G+DI++ N +++D L+ Sbjct: 72 SIEAVLKAITDEFGGVDILVN---NAGITRDNLLM 103 >3COS-A nrPDB Length = 381 Score = 35.8 bits (81), Expect = 0.027, Method: Compositional matrix adjust. Identities = 55/258 (21%), Positives = 98/258 (37%), Gaps = 59/258 (22%) Query: 1 MATGQKLMR--AVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGT 58 M T K+++ A +E G P ++ ++ V PK H+V I++ A + + + Sbjct: 2 MGTKGKVIKCKAAIAWEAGKPLCIE---EVEVAPPKAHEVRIQIIATSLCHTDATVIDSK 58 Query: 59 YSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVF------------------------ 94 + P G + AG++E++G + K GD+V Sbjct: 59 F-EGLAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKI 117 Query: 95 ----------------TSSTISGGYAEY-----------ALAADHTVYKLPEKLDFKQGA 127 TS G Y + +D + K+ + + ++ Sbjct: 118 SNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVC 177 Query: 128 AIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGL-KILGTAGTEEGQ 186 +G + T Y A I++A V G + V G GGVGL+A +A G +I+G E Sbjct: 178 LLGCGFSTGYGAAINNAKVTPGSTCAVFGL-GGVGLSAVMGCKAAGASRIIGIDINSEKF 236 Query: 187 KIVLQNGAHEVFNHREVN 204 GA + N R+++ Sbjct: 237 VKAKALGATDCLNPRDLH 254 >1Q1N-A nrPDB Length = 360 Score = 35.8 bits (81), Expect = 0.027, Method: Compositional matrix adjust. Identities = 32/146 (21%), Positives = 52/146 (35%), Gaps = 36/146 (24%) Query: 35 DHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNA-SAFKKGDRV 93 DH + IK+ ACGV + + +G + + P G ++ G + +G + S K G RV Sbjct: 33 DHDIDIKIEACGVCGSDIHCAAGHWGNMKM-PLVVGHEIVGKVVKLGPKSNSGLKVGQRV 91 Query: 94 FTSSTI----------------------------------SGGYAEYALAADHTVYKLPE 119 + + GGYA Y +H V +PE Sbjct: 92 GVGAQVFSCLECDRCKNDNEPYCTKFVTTYSQPYEDGYVSQGGYANYVRVHEHFVVPIPE 151 Query: 120 KLDFKQGAAIGIPYFTAYRALIHSAC 145 + A + T Y L+ + C Sbjct: 152 NIPSHLAAPLLCGGLTVYSPLVRNGC 177 >1Q7C-A nrPDB Length = 244 Score = 35.0 bits (79), Expect = 0.047, Method: Compositional matrix adjust. Identities = 29/97 (29%), Positives = 50/97 (51%), Gaps = 13/97 (13%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQ----NGAHEVFNHRE-- 202 G+ LV GAS G+G A + A G K++GTA +E G + + NG + N + Sbjct: 5 GKIALVTGASRGIGRAIAETLAARGAKVIGTATSENGAQAISDYLGANGKGLMLNVTDPA 64 Query: 203 --VNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLL 237 + ++KI+ GE +DI++ N +++D L+ Sbjct: 65 SIESVLEKIRAEFGE--VDILVN---NAGITRDNLLM 96 >1CDO-A nrPDB Length = 374 Score = 35.0 bits (79), Expect = 0.050, Method: Compositional matrix adjust. Identities = 75/365 (20%), Positives = 139/365 (38%), Gaps = 64/365 (17%) Query: 9 RAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETY-IRSGTYSRKPLLPY 67 +A +E P V++ +I V +P +++ IK+ A GV + Y + G + K P Sbjct: 10 KAAVAWEANKPLVIE---EIEVDVPHANEIRIKIIATGVCHTDLYHLFEGKH--KDGFPV 64 Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRVF-----------------TSSTISGG-------- 102 G + AG++E+VG + F+ G++V T+ + G Sbjct: 65 VLGHEGAGIVESVGPGVTEFQPGEKVIPLFISQCGECRFCQSPKTNQCVKGWANESPDVM 124 Query: 103 ----------------------YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRAL 140 +++Y + V K+ +G T + A Sbjct: 125 SPKETRFTCKGRKVLQFLGTSTFSQYTVVNQIAVAKIDPSAPLDTVCLLGCGVSTGFGAA 184 Query: 141 IHSACVKAGESVLVHGASGGVGLAACQIARAYGLK-ILGTAGTEEGQKIVLQNGAHEVFN 199 +++A V+ G + V G G VGLAA + G K I+ + + GA + N Sbjct: 185 VNTAKVEPGSTCAVFGL-GAVGLAAVMGCHSAGAKRIIAVDLNPDKFEKAKVFGATDFVN 243 Query: 200 HRE-VNYIDKIKKYVGEKGIDIIIEMLANVNLSKDL--SLLSHGGRVIVVGSRGTIEINP 256 + I ++ + G+D +E + NV + ++ S L G ++VG ++ Sbjct: 244 PNDHSEPISQVLSKMTNGGVDFSLECVGNVGVMRNALESCLKGWGVSVLVGWTDLHDVAT 303 Query: 257 RDTMAKESSIIGVTLFSSTKEEF---QQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHE 313 R ++F K + + A L ++ L I + PLE V +A + Sbjct: 304 RPIQLIAGRTWKGSMFGGFKGKDGVPKMVKAYLDKKVK---LDEFITHRMPLESVNDAID 360 Query: 314 NIIHG 318 + HG Sbjct: 361 LMKHG 365 >4M8S-A nrPDB Length = 248 Score = 34.3 bits (77), Expect = 0.069, Method: Compositional matrix adjust. Identities = 31/99 (31%), Positives = 49/99 (49%), Gaps = 14/99 (14%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEG-----QKIVLQNGAHEVFNHRE 202 +G+ LV GAS G+G A A G K++GTA +E G +++ G V N E Sbjct: 7 SGKIALVTGASRGIGAAIADTLAAAGAKVIGTATSESGAAAISERLAQWGGEGRVLNSAE 66 Query: 203 ----VNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLL 237 N I I+K G+ +DI++ N +++D L+ Sbjct: 67 PETVENLIADIEKTFGK--LDILVN---NAGITRDNLLM 100 >1YQX-A nrPDB Length = 366 Score = 33.1 bits (74), Expect = 0.17, Method: Compositional matrix adjust. Identities = 52/250 (20%), Positives = 98/250 (39%), Gaps = 43/250 (17%) Query: 35 DHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRV- 93 + V KV CGV + + + + P PG ++ G + VG GD+V Sbjct: 41 EEDVRFKVLYCGVCHSDLHSIKNDWGFS-MYPLVPGHEIVGEVTEVGSKVKKVNVGDKVG 99 Query: 94 --------------------------------FTSSTIS-GGYAEYALAADHTVYKLPEK 120 + TI+ GGY+ + +A + + + P+ Sbjct: 100 VGCLVGACHSCESCANDLENYCPKMILTYASIYHDGTITYGGYSNHMVANERYIIRFPDN 159 Query: 121 LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA 180 + GA + T Y L + + G+ + + G G +A + A+A+G K+ + Sbjct: 160 MPLDGGAPLLCAGITVYSPLKYFGLDEPGKHIGIVGLGGLGHVAV-KFAKAFGSKVTVIS 218 Query: 181 GTEEGQKIVLQN-GAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVN-LSKDLSLLS 238 + ++ L+N GA R D+ + +D II+ ++ V+ L LL Sbjct: 219 TSPSKKEEALKNFGADSFLVSR-----DQEQMQAAAGTLDGIIDTVSAVHPLLPLFGLLK 273 Query: 239 HGGRVIVVGS 248 G++I+VG+ Sbjct: 274 SHGKLILVGA 283 >3TWO-A nrPDB Length = 348 Score = 33.1 bits (74), Expect = 0.18, Method: Compositional matrix adjust. Identities = 58/252 (23%), Positives = 97/252 (38%), Gaps = 52/252 (20%) Query: 33 PKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGD- 91 P+D VLI + G+ + + + ++ + P PG ++AG+I+ VG FK GD Sbjct: 29 PRD--VLIDILYAGICHSDIHSAYSEW-KEGIYPMIPGHEIAGIIKEVGKGVKKFKIGDV 85 Query: 92 --------------------------RVFTSSTIS---------GGYAEYALAADHTVYK 116 VFT + GGY+ + ++ V Sbjct: 86 VGVGCFVNSCKACKPCKEHQEQFCTKVVFTYDCLDSFHDNEPHMGGYSNNIVVDENYVIS 145 Query: 117 LPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKI 176 + + ++ A + T Y L S K G V V G GG+G A + A A G ++ Sbjct: 146 VDKNAPLEKVAPLLCAGITTYSPLKFSKVTK-GTKVGVAGF-GGLGSMAVKYAVAMGAEV 203 Query: 177 LGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEML-ANVNLSKDLS 235 A E ++ L G + K E+ +D II + + +L L Sbjct: 204 SVFARNEHKKQDALSMGVKHFYTD---------PKQCKEE-LDFIISTIPTHYDLKDYLK 253 Query: 236 LLSHGGRVIVVG 247 LL++ G + +VG Sbjct: 254 LLTYNGDLALVG 265 >6C49-A nrPDB Length = 350 Score = 32.3 bits (72), Expect = 0.30, Method: Compositional matrix adjust. Identities = 44/205 (21%), Positives = 80/205 (39%), Gaps = 31/205 (15%) Query: 34 KDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRV 93 + HQV +KV CG+ + + + + + P G ++ G I A+G A + G RV Sbjct: 37 QPHQVEVKVEYCGLCHSDISVLNNEW-HSTVYPVVAGHEIIGRIVALGSEAKGLQIGQRV 95 Query: 94 ---FTSSTI-------------------------SGGYAEYALAADHTVYKLPEKLDFKQ 125 +T+ + +GG+A+ A LPE LD + Sbjct: 96 GIGWTAESCQACDECIGGQQVLCTGENIATIVGHAGGFADKVRAGWQWAIPLPEDLDPES 155 Query: 126 GAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEG 185 + T + L+ ++A V V G G +A ++ +A+G +I + + Sbjct: 156 AGPLLCGGITVFDPLLKHK-IQATHHVGVIGIGGLGHIAI-KLLKAWGCEITAFSSNPDK 213 Query: 186 QKIVLQNGAHEVFNHREVNYIDKIK 210 + + GA V N R+ + K Sbjct: 214 TEELKAMGADHVVNSRDTEAVKAQK 238 >6FG0-A nrPDB Length = 352 Score = 32.0 bits (71), Expect = 0.39, Method: Compositional matrix adjust. Identities = 26/87 (29%), Positives = 40/87 (45%), Gaps = 4/87 (4%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVE-TYIRSGTYSRKPLLP 66 M+AV+ E G V+ DI P P ++L+KV A G+ + T + LP Sbjct: 1 MKAVQYTEIGSEPVVV---DIPTPTPGPGEILLKVTAAGLCHSDITVMDMPAAQYAGGLP 57 Query: 67 YTPGSDVAGVIEAVGDNASAFKKGDRV 93 T G + G + +G+ + F GD V Sbjct: 58 LTLGHEGVGTVAELGEGVTGFGVGDAV 84 >2ISQ-A nrPDB Length = 320 Score = 31.2 bits (69), Expect = 0.58, Method: Compositional matrix adjust. Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 2/47 (4%) Query: 146 VKAGESVLVHGASG--GVGLAACQIARAYGLKILGTAGTEEGQKIVL 190 +K GESVL+ SG GVGLA A+ Y L I A ++I+L Sbjct: 61 IKPGESVLIEPTSGNTGVGLAFTAAAKGYKLIITMPASMSTERRIIL 107 >5CDY-A nrPDB Length = 244 Score = 31.2 bits (69), Expect = 0.66, Method: Compositional matrix adjust. Identities = 28/97 (28%), Positives = 49/97 (50%), Gaps = 13/97 (13%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVL----QNGAHEVFNHREVN 204 G+ LV GAS G+G A ++ G ++GTA +E+G + + +NG + N + Sbjct: 5 GKIALVTGASRGIGRAIAELLVERGACVIGTATSEKGAEAISAYLGENGKGLMLNVVDPT 64 Query: 205 YID----KIKKYVGEKGIDIIIEMLANVNLSKDLSLL 237 ID I+ GE +DI++ N +++D L+ Sbjct: 65 SIDTVLATIRAEFGE--VDILVN---NAGITRDNLLM 96 >1UUF-A nrPDB Length = 369 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 71/289 (24%), Positives = 113/289 (39%), Gaps = 63/289 (21%) Query: 27 DIAVPIPKDHQVLIKVHACGVNPVETY-IRS---GTYSRKPLLPYTPGSDVAGVIEAVGD 82 DI P + V I++ CGV + + +RS GT + P PG ++ G + AVGD Sbjct: 39 DITRREPGPNDVKIEIAYCGVCHSDLHQVRSEWAGT-----VYPCVPGHEIVGRVVAVGD 93 Query: 83 NASAFKKGDRV-----------------------------FTSSTIS------GGYAEYA 107 + GD V + S T GGY++ Sbjct: 94 QVEKYAPGDLVGVGCIVDSCKHCEECEDGLENYCDHMTGTYNSPTPDEPGHTLGGYSQQI 153 Query: 108 LAADHTVYKLPEKLDFKQGAAIGIPYF----TAYRALIH-SACVKAGESVLVHGASGGVG 162 + H Y L + +Q AA+ P T Y L H A V+ G G +G Sbjct: 154 VV--HERYVLRIRHPQEQLAAVA-PLLCAGITTYSPLRHWQAGPGKKVGVVGIGGLGHMG 210 Query: 163 LAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIII 222 + ++A A G ++ +E ++ GA EV N R D++ ++ K D I+ Sbjct: 211 I---KLAHAMGAHVVAFTTSEAKREAAKALGADEVVNSRNA---DEMAAHL--KSFDFIL 262 Query: 223 EMLANV-NLSKDLSLLSHGGRVIVVGSRGTIEINPR--DTMAKESSIIG 268 +A NL +LL G + +VG+ T +P + + K +I G Sbjct: 263 NTVAAPHNLDDFTTLLKRDGTMTLVGAPATPHKSPEVFNLIMKRRAIAG 311 >1EBD-A nrPDB Length = 455 Score = 29.6 bits (65), Expect = 1.9, Method: Compositional matrix adjust. Identities = 17/50 (34%), Positives = 27/50 (54%) Query: 177 LGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLA 226 LGTA G K+ + GA E+ + E IKK + +KG++++ LA Sbjct: 185 LGTAYANFGTKVTILEGAGEILSGFEKQMAAIIKKRLKKKGVEVVTNALA 234 >3WD7-A nrPDB Length = 403 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 26/92 (28%), Positives = 41/92 (44%), Gaps = 12/92 (13%) Query: 228 VNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQ 287 + L+KDL+ + G RV+VV S TI + S++G LF+ AAAL Sbjct: 183 LRLAKDLAENNKGSRVLVVCSENTIPTFRGPSYTHIDSLVGQALFADG-------AAALI 235 Query: 288 AGMEIGWLKPVIGSQYPLEKVAEAHENIIHGS 319 G + P + PL + A + ++ S Sbjct: 236 VGAD-----PDTSIERPLYHIVSASQTLLPDS 262 >5H83-A nrPDB Length = 360 Score = 28.9 bits (63), Expect = 3.5, Method: Compositional matrix adjust. Identities = 15/59 (25%), Positives = 27/59 (45%), Gaps = 1/59 (1%) Query: 35 DHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRV 93 ++ V KV CG + + + + P+ G ++ GV+ +G FK GD+V Sbjct: 39 ENDVQFKVLYCGTCNYDLEMSTNKFGMTKY-PFVIGHEIVGVVTEIGSKVQKFKVGDKV 96 >6DUE-A nrPDB Length = 787 Score = 28.5 bits (62), Expect = 4.6, Method: Compositional matrix adjust. Identities = 20/67 (29%), Positives = 30/67 (44%), Gaps = 1/67 (1%) Query: 133 YFTAYRALIHSACVKAGESVLVHGASG-GVGLAACQIARAYGLKILGTAGTEEGQKIVLQ 191 ++TA RAL + V ++++V G SG G A QI R + G+ I+ Sbjct: 170 FYTARRALDNLHAVNKSQTIIVSGESGAGKTEATKQIMRYFAAAKTGSMDLRIQNAIMAA 229 Query: 192 NGAHEVF 198 N E F Sbjct: 230 NPVLEAF 236 >3JC6-4 nrPDB Length = 933 Score = 28.1 bits (61), Expect = 5.5, Method: Compositional matrix adjust. Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 4/95 (4%) Query: 168 IARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLAN 227 I + ++ LGT+ + +L E H+ +NY ++ + + D ++ ++ + Sbjct: 227 IKQLNEMRELGTSNLNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVD 286 Query: 228 VNLSKDLSLLS---HGGRVIVVGS-RGTIEINPRD 258 NL DL + + R VGS +G E+NP D Sbjct: 287 NNLDYDLDEIETKFYKVRPYNVGSCKGMRELNPND 321 >3BZK-A nrPDB Length = 785 Score = 27.7 bits (60), Expect = 7.0, Method: Compositional matrix adjust. Identities = 31/150 (20%), Positives = 58/150 (38%), Gaps = 8/150 (5%) Query: 82 DNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALI 141 D F K + T+ + G E A +D+ + P K A + F + Sbjct: 182 DKLRVFMKNEATLTARVVPGKEQEGAKFSDYFEHDEPLKSAPSHRA---LAIFRGRNEGV 238 Query: 142 HSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHR 201 SA +K GE A G + IA +GL G A + ++V +++ H Sbjct: 239 LSASLKVGEE-----APGTLHPCEVMIAERFGLSNQGRAADKWLAEVVRWTWKVKLYTHL 293 Query: 202 EVNYIDKIKKYVGEKGIDIIIEMLANVNLS 231 E + +++ ++ I + L ++ L+ Sbjct: 294 ETDLFGELRDGAEDEAISVFARNLHDLLLA 323 >1NEE-A nrPDB Length = 138 Score = 27.3 bits (59), Expect = 8.7, Method: Compositional matrix adjust. Identities = 15/39 (38%), Positives = 23/39 (58%), Gaps = 1/39 (2%) Query: 172 YGLKILGTAGTEEGQKIVLQ-NGAHEVFNHREVNYIDKI 209 + L+ LGTAG EG + +LQ H + N R +Y++K Sbjct: 64 FLLRELGTAGNLEGGRAILQGKFTHFLINERIEDYVNKF 102 >3SFT-A nrPDB Length = 193 Score = 27.3 bits (59), Expect = 8.9, Method: Compositional matrix adjust. Identities = 14/25 (56%), Positives = 16/25 (64%), Gaps = 4/25 (16%) Query: 97 STISGGYAEYALAADHTVYKLPEKL 121 S I GYA+Y L A YK+PEKL Sbjct: 169 SVIEEGYADYVLPA----YKIPEKL 189 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1YB5-A nrPDB 389 e-108 2OBY-A nrPDB 280 6e-76 1WLY-A nrPDB 274 3e-74 3PII-A nrPDB 271 2e-73 1QOR-A nrPDB 264 3e-71 5K1S-A nrPDB 263 7e-71 3JYN-A nrPDB 263 9e-71 3MEQ-A nrPDB 262 1e-70 3QWB-A nrPDB 262 2e-70 1HSO-A nrPDB 261 3e-70 2EER-A nrPDB 261 5e-70 1LLU-A nrPDB 258 2e-69 1HSZ-A nrPDB 258 3e-69 4Z6K-A nrPDB 257 3e-69 1U3W-A nrPDB 257 6e-69 4RVS-A nrPDB 251 3e-67 6N7L-A nrPDB 251 3e-67 3S2F-A nrPDB 247 3e-66 4A27-A nrPDB 242 1e-64 1EE2-A nrPDB 240 6e-64 1R37-A nrPDB 238 2e-63 4J6F-A nrPDB 238 3e-63 2DFV-A nrPDB 234 4e-62 3UOG-A nrPDB 233 8e-62 2VN8-A nrPDB 232 2e-61 3TQH-A nrPDB 226 1e-59 1MC5-A nrPDB 225 3e-59 1D1T-A nrPDB 225 3e-59 1PL8-A nrPDB 223 7e-59 4EYE-A nrPDB 222 1e-58 1E3E-A nrPDB 222 2e-58 1H2B-A nrPDB 221 3e-58 3GFB-A nrPDB 221 3e-58 3HZZ-A nrPDB 221 5e-58 4Y1B-A nrPDB 219 2e-57 5ENV-A nrPDB 217 5e-57 3QE3-A nrPDB 216 1e-56 4RQU-A nrPDB 216 2e-56 4EEZ-A nrPDB 214 3e-56 5YAT-A nrPDB 213 7e-56 4A10-A nrPDB 213 1e-55 5A3V-A nrPDB 210 5e-55 2DQ4-A nrPDB 210 6e-55 2VCY-A nrPDB 209 1e-54 5VM2-A nrPDB 207 7e-54 1E3J-A nrPDB 205 2e-53 2WEK-A nrPDB 205 2e-53 1V3V-A nrPDB 203 7e-53 3SLK-A nrPDB 202 2e-52 2H6E-A nrPDB 199 2e-51 1F8F-A nrPDB 198 3e-51 3FBG-A nrPDB 197 5e-51 5TNX-A nrPDB 197 7e-51 4CPD-A nrPDB 195 2e-50 2J3K-A nrPDB 194 5e-50 1P0F-A nrPDB 194 5e-50 4OH1-A nrPDB 193 9e-50 4IDE-A nrPDB 191 3e-49 4EJ6-A nrPDB 190 9e-49 2Y05-A nrPDB 187 7e-48 5YLN-A nrPDB 180 7e-46 4UEJ-A nrPDB 177 8e-45 4DVJ-A nrPDB 176 1e-44 4ILK-A nrPDB 175 3e-44 4OAQ-A nrPDB 167 5e-42 1O89-A nrPDB 165 2e-41 3WLE-A nrPDB 162 1e-40 5LB9-A nrPDB 157 9e-39 3B70-A nrPDB 151 4e-37 5H82-A nrPDB 140 1e-33 5GXF-A nrPDB 138 2e-33 Sequences not found previously or not previously below threshold: 3COS-A nrPDB 225 3e-59 4DLA-A nrPDB 211 4e-55 1CDO-A nrPDB 207 4e-54 4JJI-A nrPDB 206 1e-53 5KIA-A nrPDB 179 2e-45 4GKV-A nrPDB 175 2e-44 6FG0-A nrPDB 157 5e-39 3IP1-A nrPDB 155 2e-38 1YKF-A nrPDB 147 7e-36 1UUF-A nrPDB 147 9e-36 3FSR-A nrPDB 146 1e-35 3FPC-A nrPDB 146 1e-35 3FPL-A nrPDB 144 4e-35 1KEV-A nrPDB 144 6e-35 1YQX-A nrPDB 141 4e-34 3TWO-A nrPDB 141 5e-34 3M6I-A nrPDB 137 6e-33 2OUI-A nrPDB 133 7e-32 5FI5-A nrPDB 133 7e-32 5Z0C-A nrPDB 133 9e-32 1Q1N-A nrPDB 133 1e-31 2VNA-A nrPDB 132 3e-31 6C49-A nrPDB 131 4e-31 5VKT-A nrPDB 130 8e-31 2ZB3-A nrPDB 128 4e-30 5H83-A nrPDB 115 3e-26 6DKH-A nrPDB 112 3e-25 2CF5-A nrPDB 109 2e-24 4JLW-A nrPDB 88 4e-18 2VWH-A nrPDB 86 2e-17 1KOL-A nrPDB 83 1e-16 2DPH-A nrPDB 82 4e-16 2CDC-A nrPDB 62 5e-10 3WID-A nrPDB 52 6e-07 3RSH-A nrPDB 42 3e-04 3D3W-A nrPDB 42 3e-04 4INE-A nrPDB 41 0.001 3DWF-A nrPDB 40 0.001 5TQV-A nrPDB 40 0.002 3F9I-A nrPDB 39 0.003 4LIS-A nrPDB 38 0.004 1Q7C-A nrPDB 38 0.005 5YWN-A nrPDB 37 0.009 3VZS-A nrPDB 37 0.009 5PGZ-A nrPDB 37 0.010 5T5Q-A nrPDB 37 0.010 5B6K-A nrPDB 37 0.010 3EMK-A nrPDB 37 0.012 1XLT-A nrPDB 37 0.015 4DIO-A nrPDB 36 0.021 3GRP-A nrPDB 36 0.022 5ILO-A nrPDB 36 0.023 3PWS-A nrPDB 36 0.028 4M8S-A nrPDB 36 0.029 5JJC-A nrPDB 36 0.030 4KRI-A nrPDB 35 0.035 5YSS-A nrPDB 35 0.037 1X14-A nrPDB 35 0.042 3LLV-A nrPDB 35 0.044 5CDY-A nrPDB 35 0.045 2YFH-A nrPDB 35 0.060 3NWN-A nrPDB 35 0.062 3PPI-A nrPDB 35 0.070 1CYD-A nrPDB 34 0.071 1DIR-A nrPDB 34 0.073 3RWB-A nrPDB 34 0.079 4IIN-A nrPDB 34 0.083 4HP8-A nrPDB 34 0.087 1ZZE-A nrPDB 33 0.12 4BO1-A nrPDB 33 0.13 4LMA-A nrPDB 33 0.13 1BW9-B nrPDB 33 0.15 5TVL-A nrPDB 33 0.15 4OAU-C nrPDB 33 0.16 1BDB-A nrPDB 33 0.17 1HXH-A nrPDB 33 0.18 4R1U-A nrPDB 33 0.21 3GDF-A nrPDB 33 0.24 3LYL-A nrPDB 33 0.25 3EZL-A nrPDB 33 0.25 2Q2Q-A nrPDB 33 0.25 6GBN-A nrPDB 33 0.26 5ITV-A nrPDB 32 0.27 4AEC-A nrPDB 32 0.29 2NNL-D nrPDB 32 0.30 1ZCJ-A nrPDB 32 0.31 1OOE-A nrPDB 32 0.34 1DIH-A nrPDB 32 0.34 3NJ4-A nrPDB 32 0.39 4AVY-A nrPDB 32 0.44 4R1T-A nrPDB 32 0.45 5IJZ-A nrPDB 32 0.46 2O23-A nrPDB 31 0.47 2BHS-A nrPDB 31 0.47 2JC3-A nrPDB 31 0.48 1AE1-A nrPDB 31 0.49 3OND-A nrPDB 31 0.49 3T4P-A nrPDB 31 0.50 3ZWA-A nrPDB 31 0.51 2VHY-A nrPDB 31 0.53 4K2X-A nrPDB 31 0.54 6GME-A nrPDB 31 0.56 1EZ1-A nrPDB 31 0.58 2ZJ1-A nrPDB 31 0.59 5WQO-A nrPDB 31 0.60 2C20-A nrPDB 31 0.66 4DI9-A nrPDB 31 0.71 4PVC-A nrPDB 31 0.75 4CQM-B nrPDB 31 0.76 5VMT-A nrPDB 31 0.81 3EVZ-A nrPDB 31 0.84 5EES-A nrPDB 31 0.86 2YVG-A nrPDB 31 0.93 1GEE-A nrPDB 31 0.96 2EKL-A nrPDB 31 0.98 2RIR-A nrPDB 31 1.00 6GCS-E nrPDB 31 1.0 2ISQ-A nrPDB 30 1.0 5U9P-A nrPDB 30 1.1 3RKU-A nrPDB 30 1.2 1E3W-A nrPDB 30 1.2 1DXY-A nrPDB 30 1.2 6CU3-A nrPDB 30 1.3 5EKU-A nrPDB 30 1.3 4M36-A nrPDB 30 1.3 1YFM-A nrPDB 30 1.3 5BZA-A nrPDB 30 1.3 4LMB-A nrPDB 30 1.3 2UVD-A nrPDB 30 1.5 4FHN-X nrPDB 30 1.6 2GLX-A nrPDB 30 1.6 2C07-A nrPDB 30 1.6 5TEN-A nrPDB 30 1.6 4X3Q-A nrPDB 30 1.7 3HG7-A nrPDB 30 1.7 3X43-A nrPDB 30 1.7 2B4Q-A nrPDB 30 1.7 2X36-A nrPDB 30 1.7 5UJU-A nrPDB 30 1.8 4GGP-A nrPDB 30 1.8 1HE4-A nrPDB 30 1.8 5JFC-L nrPDB 30 1.9 5TC4-A nrPDB 30 2.0 1QO8-A nrPDB 30 2.0 2PK3-A nrPDB 30 2.1 3N58-A nrPDB 30 2.1 1V9L-A nrPDB 30 2.1 4Z9Y-A nrPDB 30 2.2 2PNF-A nrPDB 30 2.2 1VQ1-A nrPDB 29 2.3 6EOT-A nrPDB 29 2.4 3V2G-A nrPDB 29 2.5 1LQU-A nrPDB 29 2.5 4B4O-A nrPDB 29 2.6 3JTM-A nrPDB 29 2.7 1XDW-A nrPDB 29 2.8 3X2F-A nrPDB 29 2.9 1QP8-A nrPDB 29 2.9 3ORF-A nrPDB 29 3.0 1KZH-A nrPDB 29 3.1 2X86-A nrPDB 29 3.1 1EQ2-A nrPDB 29 3.1 3ZV3-A nrPDB 29 3.3 2AS0-A nrPDB 29 3.3 4RGB-A nrPDB 29 3.4 5HMP-A nrPDB 29 3.4 3RD8-A nrPDB 29 3.7 5JXW-A nrPDB 29 3.7 4QUK-A nrPDB 28 3.9 4LAT-A nrPDB 28 4.0 3W8F-A nrPDB 28 4.1 1SMK-A nrPDB 28 4.2 3HDH-A nrPDB 28 4.2 5XJ2-A nrPDB 28 4.2 3KTC-A nrPDB 28 4.3 2AG5-A nrPDB 28 4.3 1DOH-A nrPDB 28 4.4 4CR6-A nrPDB 28 4.4 2EEZ-A nrPDB 28 4.6 1F14-A nrPDB 28 4.6 1W7I-A nrPDB 28 4.8 6JCV-A nrPDB 28 4.9 6ABI-A nrPDB 28 5.2 4D3F-A nrPDB 28 5.2 2QRJ-A nrPDB 28 5.2 6A0L-A nrPDB 28 5.5 2CB1-A nrPDB 28 5.6 3GNQ-A nrPDB 28 5.8 4HGV-A nrPDB 28 6.2 4OMU-A nrPDB 28 6.5 6C55-A nrPDB 28 6.6 1YXM-A nrPDB 28 6.7 1URG-A nrPDB 28 7.0 6J0Z-C nrPDB 28 7.3 3UF0-A nrPDB 28 7.4 3CJR-A nrPDB 28 7.4 3F4W-A nrPDB 28 7.5 3WTC-A nrPDB 28 7.6 2DKN-A nrPDB 28 7.6 4UZU-A nrPDB 28 7.8 3KWM-A nrPDB 28 7.9 6APE-A nrPDB 28 8.2 5XEM-A nrPDB 27 9.4 2HQ1-A nrPDB 27 9.4 2FWM-X nrPDB 27 9.6 1A27-A nrPDB 27 9.6 >1YB5-A nrPDB Length = 351 Score = 389 bits (999), Expect = e-108, Method: Composition-based stats. Identities = 329/329 (100%), Positives = 329/329 (100%) Query: 1 MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS 60 MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS Sbjct: 23 MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS 82 Query: 61 RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEK 120 RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEK Sbjct: 83 RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEK 142 Query: 121 LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA 180 LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA Sbjct: 143 LDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA 202 Query: 181 GTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG 240 GTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG Sbjct: 203 GTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG 262 Query: 241 GRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG 300 GRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG Sbjct: 263 GRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG 322 Query: 301 SQYPLEKVAEAHENIIHGSGATGKMILLL 329 SQYPLEKVAEAHENIIHGSGATGKMILLL Sbjct: 323 SQYPLEKVAEAHENIIHGSGATGKMILLL 351 >2OBY-A nrPDB Length = 338 Score = 280 bits (716), Expect = 6e-76, Method: Composition-based stats. Identities = 91/332 (27%), Positives = 155/332 (46%), Gaps = 12/332 (3%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67 M AV + GGPE L ++ ++A P P + +VL+KV A +N + R G Y P Sbjct: 7 MLAVHFDKPGGPENLYVK-EVAKPSPGEGEVLLKVAASALNRADLMQRQGQYDPPPGASN 65 Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQGA 127 G + +G + +G K + GG A+Y + + +PE L Q A Sbjct: 66 ILGLEASGHVAELGPGCQGHWKIGDTAMALLPGGGQAQYVTVPEGLLMPIPEGLTLTQAA 125 Query: 128 AIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQK 187 AI + TA++ L V+AG+ VL+H GVG AA Q+ R G L TAG+++ + Sbjct: 126 AIPEAWLTAFQLLHLVGNVQAGDYVLIHAGLSGVGTAAIQLTRMAGAIPLVTAGSQKKLQ 185 Query: 188 IVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVG 247 + + GA FN+++ ++ + K+ G+++I++ + K+++ L+ GR ++ G Sbjct: 186 MAEKLGAAAGFNYKKEDFSEATLKFTKGAGVNLILDCIGGSYWEKNVNCLALDGRWVLYG 245 Query: 248 SRGTIEINPRD---TMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIG-------WLKP 297 G +IN + K S+I L S + Q A + L P Sbjct: 246 LMGGGDINGPLFSKLLFKRGSLITSLLRSRDNKYKQMLVNAFTEQILPHFSTEGPQRLLP 305 Query: 298 VIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 V+ YP+ ++ EAH + + GK++L L Sbjct: 306 VLDRIYPVTEIQEAH-KYMEANKNIGKIVLEL 336 >1WLY-A nrPDB Length = 333 Score = 274 bits (702), Expect = 3e-74, Method: Composition-based stats. Identities = 88/332 (26%), Positives = 148/332 (44%), Gaps = 12/332 (3%) Query: 7 LMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRK--PL 64 ++ A + + GGP+ + ++ V P QV ++ A GVN ++TY R+G Sbjct: 1 MVMAAVIHKKGGPDNF-VWEEVKVGSPGPGQVRLRNTAIGVNFLDTYHRAGIPHPLVVGE 59 Query: 65 LPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFK 124 P G + A V+E VG + F G+RV T G Y++ L + K+P+ LD Sbjct: 60 PPIVVGFEAAAVVEEVGPGVTDFTVGERVCTCLPPLGAYSQERLYPAEKLIKVPKDLDLD 119 Query: 125 --QGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGT 182 A + + TA L + VK G+ VL+H A+GG+G AR G ++GT T Sbjct: 120 DVHLAGLMLKGMTAQYLLHQTHKVKPGDYVLIHAAAGGMGHIMVPWARHLGATVIGTVST 179 Query: 183 EEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGR 242 EE + + G H N+ ++ + +++ G KG+D++ + + L K L L G Sbjct: 180 EEKAETARKLGCHHTINYSTQDFAEVVREITGGKGVDVVYDSIGKDTLQKSLDCLRPRGM 239 Query: 243 VIVVGSRGTIEINPR---DTMAKESSII---GVTLFSSTKEEFQQYAAALQAGMEIGWLK 296 G + R D + S I + + S + E + + L ++ G L Sbjct: 240 CAAYGHASGVADPIRVVEDLGVRGSLFITRPALWHYMSNRSEIDEGSKCLFDAVKAGVLH 299 Query: 297 PVIGSQYPLEKVAEAHENIIHGSGATGKMILL 328 + +PL + A AH + G G ++LL Sbjct: 300 SSVAKTFPLREAAAAH-KYMGGRQTIGSIVLL 330 >3PII-A nrPDB Length = 339 Score = 271 bits (694), Expect = 2e-73, Method: Composition-based stats. Identities = 99/350 (28%), Positives = 159/350 (45%), Gaps = 42/350 (12%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67 M+A V +F P +K ++ P +VL+++ ACGV + + G + KP LP Sbjct: 1 MKAAVVEQFKEPLKIK---EVEKPTISYGEVLVRIKACGVCHTDLHAAHGDWPVKPKLPL 57 Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRV---------------------------FTSSTIS 100 PG + G++E VG + K GDRV ++ Sbjct: 58 IPGHEGVGIVEEVGPGVTHLKVGDRVGIPWLYSACGHCDYCLSGQETLCEHQKNAGYSVD 117 Query: 101 GGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGG 160 GGYAEY AA V K+P+ L F++ A I T Y+AL K GE V ++G GG Sbjct: 118 GGYAEYCRAAADYVVKIPDNLSFEEAAPIFCAGVTTYKAL-KVTGAKPGEWVAIYGI-GG 175 Query: 161 VGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDI 220 G A Q A+A GL ++ +E ++ + GA V N + + +K+ VG Sbjct: 176 FGHVAVQYAKAMGLNVVAVDIGDEKLELAKELGADLVVNPLKEDAAKFMKEKVGGVHA-A 234 Query: 221 IIEMLANVNLSKDLSLLSHGGRVIVVG-SRGTIEINPRDTMAKESSIIGVTLFSSTKEEF 279 ++ ++ + + GG ++VG + I DT+ IIG + T+++ Sbjct: 235 VVTAVSKPAFQSAYNSIRRGGACVLVGLPPEEMPIPIFDTVLNGIKIIGSIVG--TRKDL 292 Query: 280 QQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 Q+ ALQ E G +K +I Q PLEK+ E + ++ G G+++L L Sbjct: 293 QE---ALQFAAE-GKVKTIIEVQ-PLEKINEVFDRMLKGQ-INGRVVLTL 336 >1QOR-A nrPDB Length = 327 Score = 264 bits (676), Expect = 3e-71, Method: Composition-based stats. Identities = 93/329 (28%), Positives = 160/329 (48%), Gaps = 10/329 (3%) Query: 7 LMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLP 66 + + + GGPEVL+ + P ++++ ++ A G+N ++TYIRSG Y P LP Sbjct: 1 MATRIEFHKHGGPEVLQA-VEFTPADPAENEIQVENKAIGINFIDTYIRSGLYPP-PSLP 58 Query: 67 YTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQG 126 G++ AG++ VG K GDRV + + G Y+ LP + F+Q Sbjct: 59 SGLGTEAAGIVSKVGSGVKHIKAGDRVVYAQSALGAYSSVHNIIADKAAILPAAISFEQA 118 Query: 127 AAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQ 186 AA + T Y L + +K E L H A+GGVGL ACQ A+A G K++GT GT + Sbjct: 119 AASFLKGLTVYYLLRKTYEIKPDEQFLFHAAAGGVGLIACQWAKALGAKLIGTVGTAQKA 178 Query: 187 KIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVV 246 + L+ GA +V N+RE + ++++K+ G K + ++ + + + L L G ++ Sbjct: 179 QSALKAGAWQVINYREEDLVERLKEITGGKKVRVVYDSVGRDTWERSLDCLQRRGLMVSF 238 Query: 247 GSRGTIEINPRDTMAKESSIIGVTL-----FSSTKEEFQQYAAALQAGMEIGWLKPVIG- 300 G+ + + + VT + +T+EE + + L + + G +K + Sbjct: 239 GNSSGAVTGVNLGILNQKGSLYVTRPSLQGYITTREELTEASNELFSLIASGVIKVDVAE 298 Query: 301 -SQYPLEKVAEAHENIIHGSGATGKMILL 328 +YPL+ AHE I+ G +L+ Sbjct: 299 QQKYPLKDAQRAHE-ILESRATQGSSLLI 326 >5K1S-A nrPDB Length = 362 Score = 263 bits (673), Expect = 7e-71, Method: Composition-based stats. Identities = 94/353 (26%), Positives = 164/353 (46%), Gaps = 38/353 (10%) Query: 5 QKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPL 64 Q M+AV + FG LK+ + + +P P +VL++VHACGV + R G R Sbjct: 15 QGHMKAVVLRSFGEAGNLKMET-MPMPRPGRGEVLLRVHACGVCYHDVINRRGNLPRT-S 72 Query: 65 LPYTPGSDVAGVIEAVGDNASAFKKGDRVFT---------------------------SS 97 +P G + AG + VG + +K GDR T Sbjct: 73 VPAILGHEAAGEVIEVGPDTPGWKTGDRAATLQRMSCGDCALCRSGRNSLCKTDNRFFGE 132 Query: 98 TISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGA 157 + GGYA++ +A + ++P L + + A + TA + V+AGE+VL+ GA Sbjct: 133 ELPGGYAQFMVAPVGGLGRVPASLPWNEAATVCCTTGTAVHTVRTRGKVRAGETVLITGA 192 Query: 158 SGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKG 217 SGGVGL++ Q+AR G +++ +E + + + GA EV R +++ ++K G Sbjct: 193 SGGVGLSSVQLARLDGARVIAVTSSEAKVQALKEAGADEVIVSRGLDFASDVRKRTQGAG 252 Query: 218 IDIIIEMLANVNLSKDLSLLSHGGRVIVVGS--RGTIEINPRDTMAKESSIIGVTLFSST 275 +D+ +E++ + + L ++ GGRV+VVG+ G +++NP + KE I+G Sbjct: 253 VDVAVEIVGSATFDQTLKSMAPGGRVVVVGNLESGMVQLNPGLVIVKELEILG------A 306 Query: 276 KEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILL 328 Q G ++ + PL + A+AH + G+++L+ Sbjct: 307 YATTQAELDEALRLTATGGVRQFVTDAVPLAEAAKAHFR-LENREVAGRLVLV 358 >3JYN-A nrPDB Length = 325 Score = 263 bits (672), Expect = 9e-71, Method: Composition-based stats. Identities = 94/327 (28%), Positives = 155/327 (47%), Gaps = 8/327 (2%) Query: 7 LMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLP 66 + + ++ GGPEVL+ D P V+++ A G+N ++TY RSG Y P LP Sbjct: 1 MAKRIQFSTVGGPEVLEY-VDFEPEAPGPQAVVVRNKAIGLNFIDTYYRSGLYPA-PFLP 58 Query: 67 YTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQG 126 G++ AGV+EAVGD + FK GDRV + G Y+E + + + KL + + F+Q Sbjct: 59 SGLGAEGAGVVEAVGDEVTRFKVGDRVAYGTGPLGAYSEVHVLPEANLVKLADSVSFEQA 118 Query: 127 AAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQ 186 AA+ + T L + VK GE +L H A+GGVG ACQ A+A G K++GT + E Sbjct: 119 AALMLKGLTVQYLLRQTYQVKPGEIILFHAAAGGVGSLACQWAKALGAKLIGTVSSPEKA 178 Query: 187 KIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVV 246 GA E ++ + ++ + K ++ + + L ++ G V+ Sbjct: 179 AHAKALGAWETIDYSHEDVAKRVLELTDGKKCPVVYDGVGQDTWLTSLDSVAPRGLVVSF 238 Query: 247 G-SRGTIEINPRDTMAKESSII----GVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGS 301 G + G + +A++ S+ + +++ + Q A L + G LK Sbjct: 239 GNASGPVSGVNLGILAQKDSVYVTRPTLGSYANNAQNLQTMADELFDMLASGKLKVDGIE 298 Query: 302 QYPLEKVAEAHENIIHGSGATGKMILL 328 QY L+ A+A + TG IL+ Sbjct: 299 QYALKDAAKAQIE-LSARRTTGSTILI 324 >3MEQ-A nrPDB Length = 365 Score = 262 bits (670), Expect = 1e-70, Method: Composition-based stats. Identities = 81/353 (22%), Positives = 147/353 (41%), Gaps = 42/353 (11%) Query: 6 KLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLL 65 K M+A V FG P + ++ +P P Q+ + + A GV + + G + KP Sbjct: 24 KTMKAAVVRAFGKPLTI---DEVPIPQPGPGQIQVAIQASGVCHTDLHAAEGDWPVKPNP 80 Query: 66 PYTPGSDVAGVIEAVGDNASAFKKGDRV---------------------------FTSST 98 P+ PG + G + AVG K+GDRV T + Sbjct: 81 PFIPGHEGVGFVSAVGSGVKHVKEGDRVGIPWLYTACGHCRHCLGGWETLCEEQLNTGYS 140 Query: 99 ISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGAS 158 ++GG+AEY +A + V LP+ +DF + A + T Y+ L K G+ V++ G Sbjct: 141 VNGGFAEYVVADPNFVGHLPKNIDFNEIAPVLCAGVTVYKGL-KVTDTKPGDWVVISGI- 198 Query: 159 GGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREV-NYIDKIKKYVGEKG 217 GG+G A Q ARA GL + + + + GA N + V + I+K Sbjct: 199 GGLGHMAVQYARAMGLNVAAVDIDDRKLDLARRLGATVTVNAKTVADPAAYIRKETDGGA 258 Query: 218 IDIIIEMLANVNLSKDLSLLSHGGRVIVVG-SRGTIEINPRDTMAKESSIIGVTLFSSTK 276 +++ ++ + L +++ GG V + G G ++ + + ++ G + T+ Sbjct: 259 QGVLVTAVSPKAFEQALGMVARGGTVSLNGLPPGDFPLSIFNMVLNGVTVRGSIVG--TR 316 Query: 277 EEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 + Q+ G +K I LE + +++ G G++++ L Sbjct: 317 LDLQESLDFAAD----GKVKATI-QTGKLEDINAIFDDMRQG-NIEGRIVMDL 363 >3QWB-A nrPDB Length = 334 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 85/338 (25%), Positives = 151/338 (44%), Gaps = 20/338 (5%) Query: 3 TGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRK 62 T + + + + E GG +V+K D VP + ++LIK GVN +E+Y R G Y + Sbjct: 4 TIPEQQKVILIDEIGGYDVIKYE-DYPVPSISEEELLIKNKYTGVNYIESYFRKGIYPCE 62 Query: 63 PLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYA-LAADHTVYKLPEKL 121 PY G + +G + A G + F+ GD+V S +A+Y+ +++ V KLP+ Sbjct: 63 K--PYVLGREASGTVVAKGKGVTNFEVGDQVAYISN--STFAQYSKISSQGPVMKLPKGT 118 Query: 122 DFKQ---GAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILG 178 ++ AA + TA + VK G+ VL+ A+GGVGL Q+ + G + Sbjct: 119 SDEELKLYAAGLLQVLTALSFTNEAYHVKKGDYVLLFAAAGGVGLILNQLLKMKGAHTIA 178 Query: 179 TAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLS 238 A T+E KI + GA + N + + + ++ K+ KG+D + + L+ L Sbjct: 179 VASTDEKLKIAKEYGAEYLINASKEDILRQVLKFTNGKGVDASFDSVGKDTFEISLAALK 238 Query: 239 HGGRVIVVGSRGTI-------EINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGME 291 G + G+ + ++P++ + G + + EE++ Y+ + Sbjct: 239 RKGVFVSFGNASGLIPPFSITRLSPKNITLVRPQLYG---YIADPEEWKYYSDEFFGLVN 295 Query: 292 IGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 L I YPL A +I GK++L + Sbjct: 296 SKKLNIKIYKTYPLRDYRTAAADI-ESRKTVGKLVLEI 332 >1HSO-A nrPDB Length = 374 Score = 261 bits (668), Expect = 3e-70, Method: Composition-based stats. Identities = 78/376 (20%), Positives = 148/376 (39%), Gaps = 64/376 (17%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67 +A ++E P ++ ++ V PK H+V IK+ A G+ + ++ SGT LP Sbjct: 9 CKAAVLWELKKPFSIE---EVEVAPPKAHEVRIKMVAVGICGTDDHVVSGTMVTP--LPV 63 Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGG------------------------- 102 G + AG++E+VG+ + K GD+V + G Sbjct: 64 ILGHEAAGIVESVGEGVTTVKPGDKVIPLAIPQCGKCRICKNPESNYCLKNDVSNPQGTL 123 Query: 103 ----------------------YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRAL 140 +++Y + ++ V K+ ++ IG + T Y + Sbjct: 124 QDGTSRFTCRRKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSA 183 Query: 141 IHSACVKAGESVLVHGASGGVGLAACQIARAYG-LKILGTAGTEEGQKIVLQNGAHEVFN 199 ++ A V G + V G GGVGL+A +A G +I+ ++ + GA E N Sbjct: 184 VNVAKVTPGSTCAVFGL-GGVGLSAIMGCKAAGAARIIAVDINKDKFAKAKELGATECIN 242 Query: 200 HREV-NYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSH--GGRVIVVGSR---GTIE 253 ++ I ++ K + + G+D E++ ++ L H G ++VG + Sbjct: 243 PQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLS 302 Query: 254 INPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHE 313 +NP + + + +KE + A A + L +I P EK+ E + Sbjct: 303 MNPMLLLTGRTWKGAILGGFKSKECVPKLVADFMA--KKFSLDALITHVLPFEKINEGFD 360 Query: 314 NIIHGSGATGKMILLL 329 + G + + IL+ Sbjct: 361 LLHSGK--SIRTILMF 374 >2EER-A nrPDB Length = 347 Score = 261 bits (666), Expect = 5e-70, Method: Composition-based stats. Identities = 99/357 (27%), Positives = 157/357 (43%), Gaps = 47/357 (13%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKP---- 63 MRA+R+ E G P L+ DI +P PK QVLIK+ A GV + ++R G + Sbjct: 1 MRAMRLVEIGKPLKLE---DIPIPKPKGSQVLIKIEAAGVCHSDVHMRQGRFGNLRIVED 57 Query: 64 ---LLPYTPGSDVAGVIEAVGDNASAFKKGDRV--------------------------F 94 LP T G ++AG IE VGD + KGD V + Sbjct: 58 LGVKLPVTLGHEIAGRIEEVGDEVVGYSKGDLVAVNPWEGEGNCYYCRIGEEHLCDSPRW 117 Query: 95 TSSTISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLV 154 G YAEY L + +L + A + T YRA+ A + ++++V Sbjct: 118 LGINYDGAYAEYVLVPHYKYLYKLRRLSAVEAAPLTCSGVTTYRAV-RKASLDPSKTLVV 176 Query: 155 HGASGGVGLAACQIARA-YGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYV 213 GA GG+G A QIA+A G I+G EE + + GA V N + + +I++ Sbjct: 177 IGAGGGLGTMAIQIAKAVSGATIIGVDVREEALEAAKRAGADYVINASSQDPVSEIRRIT 236 Query: 214 GEKGIDIIIE-MLANVNLSKDLSLLSHGGRVIVVGSRGT-IEINPRDTMAKESSIIGVTL 271 KG D +I+ + LS +L+ G+ ++VG G ++ + E IG + Sbjct: 237 QGKGADAVIDLNNSEKTLSIYPYVLAKQGKYVMVGLFGADLKYHAPLITLNEVQFIGSLV 296 Query: 272 FSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILL 328 + +F + + E G +KP++ LE+ EA +N + A G+ +L+ Sbjct: 297 G--NQSDF----LGIMSLAEAGKVKPMVTKTMKLEEANEAIDN-LENFKAVGRQVLV 346 >1LLU-A nrPDB Length = 342 Score = 258 bits (660), Expect = 2e-69, Method: Composition-based stats. Identities = 87/355 (24%), Positives = 157/355 (44%), Gaps = 42/355 (11%) Query: 3 TGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRK 62 T + M+A V +G P ++ ++ VP+P QVL+K+ A GV + + G + K Sbjct: 2 TLPQTMKAAVVHAYGAPLRIE---EVKVPLPGPGQVLVKIEASGVCHTDLHAAEGDWPVK 58 Query: 63 PLLPYTPGSDVAGVIEAVGDNASAFKKGDRV---------------------------FT 95 P LP+ PG + G + AVG + K+GDRV T Sbjct: 59 PPLPFIPGHEGVGYVAAVGSGVTRVKEGDRVGIPWLYTACGCCEHCLTGWETLCESQQNT 118 Query: 96 SSTISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVH 155 +++GGYAEY LA + V LP+ ++F + A I T Y+ L + + G+ V + Sbjct: 119 GYSVNGGYAEYVLADPNYVGILPKNVEFAEIAPILCAGVTVYKGLKQT-NARPGQWVAIS 177 Query: 156 GASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGE 215 G GG+G A Q ARA GL + + ++ + GA N R+ + ++ I++ +G Sbjct: 178 GI-GGLGHVAVQYARAMGLHVAAIDIDDAKLELARKLGASLTVNARQEDPVEAIQRDIGG 236 Query: 216 KGIDIIIEMLANVNLSKDLSLLSHGGRVIVVG-SRGTIEINPRDTMAKESSIIGVTLFSS 274 +++ ++N + + + GG + +VG G D + K I G + Sbjct: 237 AH-GVLVTAVSNSAFGQAIGMARRGGTIALVGLPPGDFPTPIFDVVLKGLHIAGSIVG-- 293 Query: 275 TKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 T+ + Q+ G+ + P L+ + + + + G G+++L + Sbjct: 294 TRADLQEALDFAGEGLVKATIHP-----GKLDDINQILDQMRAGQ-IEGRIVLEM 342 >1HSZ-A nrPDB Length = 374 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 79/376 (21%), Positives = 147/376 (39%), Gaps = 64/376 (17%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67 +A ++E P ++ D+ V PK ++V IK+ A G+ + ++ SG LP Sbjct: 9 CKAAVLWEVKKPFSIE---DVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTP--LPV 63 Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGG------------------------- 102 G + AG++E+VG+ + K GD+V T G Sbjct: 64 ILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTL 123 Query: 103 ----------------------YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRAL 140 +++Y + ++ V K+ ++ IG + T Y + Sbjct: 124 QDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSA 183 Query: 141 IHSACVKAGESVLVHGASGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEVFN 199 ++ A V G + V G GGVGL+A +A G +I+ ++ + GA E N Sbjct: 184 VNVAKVTPGSTCAVFGL-GGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECIN 242 Query: 200 HREV-NYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSH--GGRVIVVG---SRGTIE 253 ++ I ++ K + + G+D E++ ++ L H G ++VG + + Sbjct: 243 PQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLS 302 Query: 254 INPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHE 313 INP + + V +KE + A A + L +I P EK+ E + Sbjct: 303 INPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMA--KKFSLDALITHVLPFEKINEGFD 360 Query: 314 NIIHGSGATGKMILLL 329 + G + + +L Sbjct: 361 LLHSGK--SIRTVLTF 374 >4Z6K-A nrPDB Length = 346 Score = 257 bits (658), Expect = 3e-69, Method: Composition-based stats. Identities = 80/348 (22%), Positives = 154/348 (44%), Gaps = 42/348 (12%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67 M+A + EFG ++ ++ +P P ++++K+ A GV + + G + KP P+ Sbjct: 1 MKAAVLHEFGQSLQIE---EVDIPTPGAGEIVVKMQASGVCHTDLHAVEGDWPVKPSPPF 57 Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRV---------------------------FTSSTIS 100 PG + G+I AVG+ + K+GDRV + +++ Sbjct: 58 IPGHEGVGLITAVGEGVTHVKEGDRVGVAWLYSACGHCTHCLGGWETLCESQQNSGYSVN 117 Query: 101 GGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGG 160 G +AEY LA + V +PE +D + A + T Y+ L + K G+ V++ G GG Sbjct: 118 GSFAEYVLANANYVGIIPESVDSIEIAPVLCAGVTVYKGLKMT-DTKPGDWVVISGI-GG 175 Query: 161 VGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDI 220 +G A Q A A GL + ++ + GA N + + + ++K +G Sbjct: 176 LGHMAVQYAIAMGLNVAAVDIDDDKLAFAKKLGAKVTVNAKNTDPAEYLQKEIGGAH-GA 234 Query: 221 IIEMLANVNLSKDLSLLSHGGRVIVVG-SRGTIEINPRDTMAKESSIIGVTLFSSTKEEF 279 ++ ++ + LS+L GG ++ G G ++ DT+ +I G + T+ + Sbjct: 235 LVTAVSAKAFDQALSMLRRGGTLVCNGLPPGDFPVSIFDTVLNGITIRGSIVG--TRLDL 292 Query: 280 QQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 Q+ G +K + ++ PLE + + E + G G++++ Sbjct: 293 QESLD----MAAAGKVKATVTAE-PLENINDIFERMRQGK-IEGRIVI 334 >1U3W-A nrPDB Length = 374 Score = 257 bits (656), Expect = 6e-69, Method: Composition-based stats. Identities = 77/376 (20%), Positives = 145/376 (38%), Gaps = 64/376 (17%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67 +A ++E P ++ ++ V PK H+V IK+ A G+ + ++ SG LP Sbjct: 9 CKAAVLWELKKPFSIE---EVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLVTP--LPV 63 Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGG------------------------- 102 G + AG++E+VG+ + K GD+V T G Sbjct: 64 ILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTL 123 Query: 103 ----------------------YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRAL 140 +++Y + ++ V K+ ++ IG + T Y + Sbjct: 124 QDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSA 183 Query: 141 IHSACVKAGESVLVHGASGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEVFN 199 + A V G + V G GGVGL+ +A G +I+ ++ + GA E N Sbjct: 184 VKVAKVTPGSTCAVFGL-GGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECIN 242 Query: 200 HREV-NYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSH--GGRVIVVGSR---GTIE 253 ++ I ++ K + + G+D E++ ++ L H G ++VG + Sbjct: 243 PQDYKKPIQEVLKEMTDGGVDFSFEVIGQLDTMMASLLCCHEACGTSVIVGVPPDSQNLS 302 Query: 254 INPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHE 313 INP + + + +KE + A A + L +I + P EK+ E + Sbjct: 303 INPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMA--KKFSLDALITNVLPFEKINEGFD 360 Query: 314 NIIHGSGATGKMILLL 329 + G + + +L Sbjct: 361 LLRSGK--SIRTVLTF 374 >4RVS-A nrPDB Length = 329 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 102/333 (30%), Positives = 162/333 (48%), Gaps = 16/333 (4%) Query: 7 LMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLP 66 M A+ V E GGP VL+ D P P ++LIK A GVN ++TY RSG Y R LP Sbjct: 1 SMHAIEVTETGGPGVLR-HVDQPQPQPGHGELLIKAEAIGVNFIDTYFRSGQYPR--ELP 57 Query: 67 YTPGSDVAGVIEAVGDNASA----FKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLD 122 + GS+V G +EAVG +A GDRV ++S +G YAE+ A K+P+ + Sbjct: 58 FVIGSEVCGTVEAVGPGVTAADTAISVGDRVVSASA-NGAYAEFCTAPASLTAKVPDDVT 116 Query: 123 FKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGT 182 + A+ + TA+ L VK G++VLVH +GGVGL Q A G++++ T T Sbjct: 117 SEVAASALLKGLTAHYLLKSVYPVKRGDTVLVHAGAGGVGLILTQWATHLGVRVITTVST 176 Query: 183 EEGQKIVLQNGAHEVFNHRE--VNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG 240 E K+ GA V ++ E + ++++ G G+ + + + L+ L+ Sbjct: 177 AEKAKLSKDAGADVVLDYPEDAWQFAGRVRELTGGTGVQAVYDGVGATTFDASLASLAVR 236 Query: 241 GRVIVVGSRGT--IEINPRDTMAKESSII---GVTLFSSTKEEFQQYAAALQAGMEIGWL 295 G + + G+ ++P+ A S + + F+ T EEF AA L + + Sbjct: 237 GTLALFGAASGPVPPVDPQRLNAAGSVYLTRPSLFHFTRTGEEFSWRAAELFDAIGNEAI 296 Query: 296 KPVIGSQYPLEKVAEAHENIIHGSGATGKMILL 328 +G +YPL AH++ + G ++LL Sbjct: 297 TVAVGGRYPLADALRAHQD-LEARKTVGSVVLL 328 >6N7L-A nrPDB Length = 353 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 82/351 (23%), Positives = 151/351 (43%), Gaps = 43/351 (12%) Query: 5 QKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPL 64 K M+A V +G P ++ ++ V P ++VL+KV ACGV + + G + KP Sbjct: 11 PKTMKAAVVQGYGEPLKIQ---EVPVREPGRYEVLVKVMACGVCHTDLHAVDGDWPAKPK 67 Query: 65 LPYTPGSDVAGVIEAVGDNASAFKKGDRV---------------------------FTSS 97 +P PG + G++ A G +A K+GD V Sbjct: 68 MPLIPGHEGVGIVVACGPDA-MVKEGDAVGVPWLYSACGCCDYCITGWETLCEAQQNGGY 126 Query: 98 TISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGA 157 ++ GG+AEY +A V L ++F + A I T Y+ L + K GE V + G Sbjct: 127 SVDGGFAEYVIADSRYVGHLKSNVNFLEIAPILCAGVTVYKGLKET-ETKPGEWVAISGI 185 Query: 158 SGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKG 217 GG+G A Q A+A G+ + ++ ++ + GA N + + + K VG Sbjct: 186 -GGLGHVAVQYAKAMGMHVAAIDVADDKLELAKKLGADLTVNAKTTDPGTYLHKEVGGMH 244 Query: 218 IDIIIEMLANVNLSKDLSLLSHGGRVIVVG-SRGTIEINPRDTMAKESSIIGVTLFSSTK 276 +I ++ + + + +L G + + G G+ E+ +T+ K ++ G + T+ Sbjct: 245 -GALITAVSPIAFKQGIDVLRRKGTIALNGLPPGSFELPIFETVLKRITVRGSIVG--TR 301 Query: 277 EEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 ++ Q+ G +K + S LE + + + + G G+++L Sbjct: 302 KDLQEALDF----ANEGLVKATVTSA-KLEDINDVFDKMKKGQ-IDGRIVL 346 >3S2F-A nrPDB Length = 340 Score = 247 bits (632), Expect = 3e-66, Method: Composition-based stats. Identities = 86/349 (24%), Positives = 149/349 (42%), Gaps = 42/349 (12%) Query: 7 LMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLP 66 +M+A V FG P + ++ VP P QV +K+ A GV + + G + KP LP Sbjct: 2 MMKAAVVRAFGAPLTI---DEVPVPQPGPGQVQVKIEASGVCHTDLHAADGDWPVKPTLP 58 Query: 67 YTPGSDVAGVIEAVGDNASAFKKGDRV---------------------------FTSSTI 99 + PG + G + AVG S K+GDRV T ++ Sbjct: 59 FIPGHEGVGYVSAVGSGVSRVKEGDRVGVPWLYSACGYCEHCLQGWETLCEKQQNTGYSV 118 Query: 100 SGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASG 159 +GGY EY +A + V LP+K+ F + A I T Y+ L + G+ V++ G G Sbjct: 119 NGGYGEYVVADPNYVGLLPDKVGFVEIAPILCAGVTVYKGL-KVTDTRPGQWVVISGI-G 176 Query: 160 GVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGID 219 G+G A Q ARA GL++ + + + GA N R+ + ++K +G Sbjct: 177 GLGHVAVQYARAMGLRVAAVDIDDAKLNLARRLGAEVAVNARDTDPAAWLQKEIGGAH-G 235 Query: 220 IIIEMLANVNLSKDLSLLSHGGRVIVVG-SRGTIEINPRDTMAKESSIIGVTLFSSTKEE 278 +++ ++ S+ + ++ GG + + G G D + K +I G + T+ + Sbjct: 236 VLVTAVSPKAFSQAIGMVRRGGTIALNGLPPGDFGTPIFDVVLKGITIRGSIVG--TRSD 293 Query: 279 FQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 Q+ G +K + L+ V + + G G+++L Sbjct: 294 LQESLDF----AAHGDVKATVS-TAKLDDVNDVFGRLREGK-VEGRVVL 336 >4A27-A nrPDB Length = 349 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 106/345 (30%), Positives = 168/345 (48%), Gaps = 31/345 (8%) Query: 7 LMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLP 66 MRAV + FGG L+L A+P P+D ++ I+V ACG+N ++ +R G P P Sbjct: 3 EMRAVVLAGFGGLNKLRLFRK-AMPEPQDGELKIRVKACGLNFIDLMVRQGNIDNPPKTP 61 Query: 67 YTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQG 126 PG + +G++EA+GD+ ++ GDRV + +AE VYK+P+ + F + Sbjct: 62 LVPGFECSGIVEALGDSVKGYEIGDRVMAFVNYN-AWAEVVCTPVEFVYKIPDDMSFSEA 120 Query: 127 AAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAY-GLKILGTAGTEEG 185 AA + + TAY L A ++ G SVLVH A GGVG A Q+ + + GTA T + Sbjct: 121 AAFPMNFVTAYVMLFEVANLREGMSVLVHSAGGGVGQAVAQLCSTVPNVTVFGTASTFKH 180 Query: 186 QKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIV 245 + +++ +F+ R +Y+ ++K+ E G+DI+++ L N K LSLL G I+ Sbjct: 181 E--AIKDSVTHLFD-RNADYVQEVKRISAE-GVDIVLDCLCGDNTGKGLSLLKPLGTYIL 236 Query: 246 VGSRGTI------------------EINPRDTMAKESSIIGVTLFS-----STKEEFQQY 282 GS + ++NP + I G +L + + Sbjct: 237 YGSSNMVTGETKSFFSFAKSWWQVEKVNPIKLYEENKVIAGFSLLNLLFKQGRAGLIRGV 296 Query: 283 AAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 L +KPV+ S + LE+V EA + I H G GK+IL Sbjct: 297 VEKLIGLYNQKKIKPVVDSLWALEEVKEAMQRI-HDRGNIGKLIL 340 >1EE2-A nrPDB Length = 373 Score = 240 bits (613), Expect = 6e-64, Method: Composition-based stats. Identities = 74/375 (19%), Positives = 144/375 (38%), Gaps = 63/375 (16%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67 +A ++E P ++ ++ V PK H+V IK+ A G+ + ++ SGT LP Sbjct: 9 CKAAVLWEQKKPFSIE---EVEVAPPKAHEVRIKMVAAGICRSDDHVVSGTLVAP--LPV 63 Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGG------------------------- 102 G + AG++E++G+ + + GD+V G Sbjct: 64 IAGHEAAGIVESIGEGVTTVRPGDKVIPLFIPQCGKCSVCKHPEGNLCLKNLSMPRGTMQ 123 Query: 103 ---------------------YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALI 141 +++Y + + +V K+ ++ +G + T Y + + Sbjct: 124 DGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLVGCGFSTGYGSAV 183 Query: 142 HSACVKAGESVLVHGASGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEVFNH 200 A V G + V G GGVGL+ +A G +I+G ++ + GA E N Sbjct: 184 KVAKVTQGSTCAVFGL-GGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNP 242 Query: 201 REV-NYIDKIKKYVGEKGIDIIIEMLAN-VNLSKDLSLLSHG-GRVIVVGSR---GTIEI 254 ++ I ++ + G+D E++ + LS G ++VG + + Sbjct: 243 QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVAALSCCQEAYGVSVIVGVPPDSQNLSM 302 Query: 255 NPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHEN 314 NP ++ + + +K+ + A A + L P+I P EK+ E + Sbjct: 303 NPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMA--KKFALDPLITHVLPFEKINEGFDL 360 Query: 315 IIHGSGATGKMILLL 329 + G + + IL Sbjct: 361 LRSGK--SIRTILTF 373 >1R37-A nrPDB Length = 347 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 102/356 (28%), Positives = 157/356 (44%), Gaps = 45/356 (12%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKP---- 63 MRAVR+ E G P L+ +I VP PK QVLIKV A GV + ++R G + Sbjct: 1 MRAVRLVEIGKPLSLQ---EIGVPKPKGPQVLIKVEAAGVCHSDVHMRQGRFGNLRIVED 57 Query: 64 ---LLPYTPGSDVAGVIEAVGDNASAFKKGDRV--------------------------F 94 LP T G ++AG IE VGD + KGD V + Sbjct: 58 LGVKLPVTLGHEIAGKIEEVGDEVVGYSKGDLVAVNPWQGEGNCYYCRIGEEHLCDSPRW 117 Query: 95 TSSTISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLV 154 G YAEY + + +L+ + A + T YRA+ A + +++LV Sbjct: 118 LGINFDGAYAEYVIVPHYKYMYKLRRLNAVEAAPLTCSGITTYRAV-RKASLDPTKTLLV 176 Query: 155 HGASGGVGLAACQIARA-YGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYV 213 GA GG+G A QIA+A G I+G EE + + GA V N + + +I++ Sbjct: 177 VGAGGGLGTMAVQIAKAVSGATIIGVDVREEAVEAAKRAGADYVINASMQDPLAEIRRIT 236 Query: 214 GEKGIDIIIE-MLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLF 272 KG+D +I+ + LS L+ G+ ++VG G +++ + S I V Sbjct: 237 ESKGVDAVIDLNNSEKTLSVYPKALAKQGKYVMVGLFGA-DLHYHAPLITLSEIQFVGSL 295 Query: 273 SSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILL 328 + +F + E G +KP+I LE+ EA +N + A G+ +L+ Sbjct: 296 VGNQSDF----LGIMRLAEAGKVKPMITKTMKLEEANEAIDN-LENFKAIGRQVLI 346 >4J6F-A nrPDB Length = 382 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 96/363 (26%), Positives = 157/363 (43%), Gaps = 44/363 (12%) Query: 1 MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS 60 M + K M AV + GG E L D+ VP P +VLIKV ACG+N + ++R G Y Sbjct: 27 MHSVPKTMTAVLLTGHGGLEKLVYSRDVPVPAPAAGEVLIKVTACGMNNTDVWVREGAYG 86 Query: 61 RKP---------------LLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTI------ 99 + P G+D G I AVG+ + G+RV +I Sbjct: 87 TEDDPSAVSTWRRHGNTLTFPRIQGTDTVGHIVAVGEGVDRARIGERVMVDFSIYNRDDD 146 Query: 100 ------------SGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVK 147 GGYAEY + + L + A Y T R L A + Sbjct: 147 SLADIDYMGHGRDGGYAEYMALPAENAHVVATDLTDIELATFCCAYLTGERML-ERARLA 205 Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYID 207 AGE+VLV GASGGVG A Q+ARA G + AG + +L GA V + + + Sbjct: 206 AGETVLVTGASGGVGSAIIQLARARGAVPIAVAG-PGKEAAMLDIGAQAVVTRGQGDLAE 264 Query: 208 KIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGT--IEINPRDTMAKESS 265 ++ G + ID++ +++ + L +L GR G+ ++++ R K+ Sbjct: 265 AVEAASGGRPIDVVADLVGGPLFNDLLKILRPEGRYTTAGAIAGPVVQLDLRTMYLKQLE 324 Query: 266 IIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKM 325 + G + ++ +F++ +E ++P++G YPL + A + + GK+ Sbjct: 325 LHGSS--QGSRADFRRLV----RYIEEKKIRPLVGGVYPLSEFHRAQTDFM-AKNFVGKL 377 Query: 326 ILL 328 +++ Sbjct: 378 VVV 380 >2DFV-A nrPDB Length = 347 Score = 234 bits (597), Expect = 4e-62, Method: Composition-based stats. Identities = 84/357 (23%), Positives = 151/357 (42%), Gaps = 45/357 (12%) Query: 6 KLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTY--SRKP 63 + M A+ + G L ++ VP P +VLIKV A + + +I + Sbjct: 2 EKMVAIMKTKPGYGAEL---VEVDVPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRI 58 Query: 64 LLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTI------------------------ 99 P G +VAG + +G + GD V + I Sbjct: 59 KPPQIMGHEVAGEVVEIGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGV 118 Query: 100 --SGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGA 157 G +AEYA+ ++K P+ + + A + P A ++ A +G+SVL+ GA Sbjct: 119 DTDGVFAEYAVVPAQNIWKNPKSIPP-EYATLQEPLGNAVDTVL--AGPISGKSVLITGA 175 Query: 158 SGGVGLAACQIARAYGLK-ILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEK 216 G +GL +A+A G ++ + ++ +++ + GA V N E + + ++ Sbjct: 176 -GPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGN 234 Query: 217 GIDIIIEMLA-NVNLSKDLSLLSHGGRVIVVGS-RGTIEIN-PRDTMAKESSIIGVTLFS 273 G+D+ +E L + L ++ GRV ++G G + I+ + K +I G+T Sbjct: 235 GVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVTIDFNNLIIFKALTIYGIT-GR 293 Query: 274 STKEEFQQYAAALQAGMEIGWLKPVIGSQYP-LEKVAEAHENIIHGSGATGKMILLL 329 E + + LQ+G L P+I +Y +K EA E + G TGK++ +L Sbjct: 294 HLWETWYTVSRLLQSGKLN--LDPIITHKYKGFDKYEEAFELMRAGK--TGKVVFML 346 >3UOG-A nrPDB Length = 363 Score = 233 bits (595), Expect = 8e-62, Method: Composition-based stats. Identities = 81/336 (24%), Positives = 151/336 (44%), Gaps = 35/336 (10%) Query: 19 PEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIE 78 P LKL ++ VP +H ++++ A +N + + P+ P SD++GV+E Sbjct: 38 PHDLKL-AERPVPEAGEHDIIVRTLAVSLNYRDKLVLETGMGLDLAFPFVPASDMSGVVE 96 Query: 79 AVGDNASAFKKGDRVFT-----------------------SSTISGGYAEYALAADHTVY 115 AVG + + F+ GDRV + G +EY + + Sbjct: 97 AVGKSVTRFRPGDRVISTFAPGWLDGLRPGTGRTPAYETLGGAHPGVLSEYVVLPEGWFV 156 Query: 116 KLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLK 175 P+ LD + + + TA+ AL+ ++AG+ V+V G +GGV L QIA+A G + Sbjct: 157 AAPKSLDAAEASTLPCAGLTAWFALVEKGHLRAGDRVVVQG-TGGVALFGLQIAKATGAE 215 Query: 176 ILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLS 235 ++ T+ + E GA N E ++++++ G++G D I+E+ L + L Sbjct: 216 VIVTSSSREKLDRAFALGADHGINRLEEDWVERVYALTGDRGADHILEIAGGAGLGQSLK 275 Query: 236 LLSHGGRVIVVGSRGTIEI--NPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIG 293 ++ GR+ V+G E+ + K + G+++ ++ L ++ Sbjct: 276 AVAPDGRISVIGVLEGFEVSGPVGPLLLKSPVVQGISVG------HRRALEDLVGAVDRL 329 Query: 294 WLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 LKPVI +Y +V EA ++ G GK+++ Sbjct: 330 GLKPVIDMRYKFTEVPEALAHLD--RGPFGKVVIEF 363 >2VN8-A nrPDB Length = 375 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 86/356 (24%), Positives = 159/356 (44%), Gaps = 43/356 (12%) Query: 9 RAVRVFEFGGPEVLKLRSDIAVPIPK-DHQVLIKVHACGVNPVETYIRSG------TYSR 61 A + ++G EVL+ ++ +PI ++V++KVHA VNP++ +RSG R Sbjct: 23 MAWVIDKYGKNEVLRFTQNMMMPIIHYPNEVIVKVHAASVNPIDVNMRSGYGATALNMKR 82 Query: 62 KP--------LLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTS--STISGGYAEYALAAD 111 P P T G DV+GV+ G + FK GD V+ + G +E+ + + Sbjct: 83 DPLHVKIKGEEFPLTLGRDVSGVVMECGLDVKYFKPGDEVWAAVPPWKQGTLSEFVVVSG 142 Query: 112 HTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVK----AGESVLVHGASGGVGLAACQ 167 + V P+ L Q A++ TA+ A+ + G+ VL+ GASGGVG A Q Sbjct: 143 NEVSHKPKSLTHTQAASLPYVALTAWSAINKVGGLNDKNCTGKRVLILGASGGVGTFAIQ 202 Query: 168 IARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLAN 227 + +A+ + +++ ++V + GA +V +++ + +++K K D I++ + Sbjct: 203 VMKAWDAHVTAVC-SQDASELVRKLGADDVIDYKSGSVEEQLKSL---KPFDFILDNVGG 258 Query: 228 --VNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYA-- 283 + D G + + + + ++ R +A GVT+ S + F + Sbjct: 259 STETWAPDFLKKWSGATYVTLVTPFLLNMD-RLGIADGMLQTGVTVGSKALKHFWKGVHY 317 Query: 284 ------------AALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 + ++ G ++PVI +P KV EA + G A GK ++ Sbjct: 318 RWAFFMASGPCLDDIAELVDAGKIRPVIEQTFPFSKVPEAFLKVERGH-ARGKTVI 372 >3TQH-A nrPDB Length = 321 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 89/335 (26%), Positives = 153/335 (45%), Gaps = 22/335 (6%) Query: 2 ATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTY-- 59 + K M+A++ +FG P+VLKL D P + +Q+LIKVHA +NP++ R+G+ Sbjct: 1 SNAMKEMKAIQFDQFGPPKVLKL-VDTPTPEYRKNQMLIKVHAASLNPIDYKTRNGSGFV 59 Query: 60 --SRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFT---SSTISGGYAEYALAADHTV 114 K LP G D +G + +G + + GD+V YAEY A+ T+ Sbjct: 60 AKKLKNNLPSGLGYDFSGEVIELGSDVNNVNIGDKVMGIAGFPDHPCCYAEYVCASPDTI 119 Query: 115 YKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGL 174 + EKL F Q A++ TA +AL + A VK G+ VL+H +GGVG A Q+A+ G Sbjct: 120 IQKLEKLSFLQAASLPTAGLTALQAL-NQAEVKQGDVVLIHAGAGGVGHLAIQLAKQKGT 178 Query: 175 KILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDL 234 ++ TA ++ + GA + N+ E +++ I +D +I+++ + + Sbjct: 179 TVITTA-SKRNHAFLKALGAEQCINYHEEDFLLAI-----STPVDAVIDLVGGDVGIQSI 232 Query: 235 SLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGW 294 L G ++ V + + K G+ + +E L + Sbjct: 233 DCLKETGCIVSVPTITAGRV-IEVAKQKHRRAFGLLKQFNIEELHY-----LGKLVSEDK 286 Query: 295 LKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 L+ I + L + AHE + G GK++ + Sbjct: 287 LRIEISRIFQLSEAVTAHELLETGH-VRGKLVFKV 320 >1MC5-A nrPDB Length = 374 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 75/375 (20%), Positives = 133/375 (35%), Gaps = 61/375 (16%) Query: 1 MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS 60 MA +A +E G P ++ +I V PK H+V IK+ A V + Y SG Sbjct: 1 MANEVIKCKAAVAWEAGKPLSIE---EIEVAPPKAHEVRIKIIATAVCHTDAYTLSGA-D 56 Query: 61 RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGG------------------ 102 + P G + AG++E+VG+ + K GD V G Sbjct: 57 PEGCFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRV 116 Query: 103 -----------------------------YAEYALAADHTVYKLPEKLDFKQGAAIGIPY 133 ++EY + AD +V K+ + +G Sbjct: 117 TQGKGLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGI 176 Query: 134 FTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQN 192 T Y A +++A ++ G V G GGVGLA + G +I+G ++ + Sbjct: 177 STGYGAAVNTAKLEPGSVCAVFGL-GGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEF 235 Query: 193 GAHEVFNHREVN-YIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGG-----RVIVV 246 GA E N ++ + I ++ + + G+D E + NV + + H G V V Sbjct: 236 GATECINPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVA 295 Query: 247 GSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLE 306 S I P + + + E + + + + + + + Sbjct: 296 ASGEEIATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMS--KKIKVDEFVTHNLSFD 353 Query: 307 KVAEAHENIIHGSGA 321 ++ +A E + G Sbjct: 354 EINKAFELMHSGKSI 368 >1D1T-A nrPDB Length = 373 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 69/375 (18%), Positives = 140/375 (37%), Gaps = 63/375 (16%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67 +A ++E P ++ +I V PK +V IK+ A G+ + ++ GT K P Sbjct: 9 CKAAVLWEQKQPFSIE---EIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVSK--FPV 63 Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISG-------------------------- 101 G + G++E++G+ + K GD+V Sbjct: 64 IVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLA 123 Query: 102 --------------------GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALI 141 + EY + + +V K+ + ++ IG + T Y A + Sbjct: 124 DGTTRFTCKGKPVHHFLNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAV 183 Query: 142 HSACVKAGESVLVHGASGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEVFNH 200 + VK G + +V G GGVGL+ ++ G +I+G ++ + + GA E + Sbjct: 184 KTGKVKPGSTCVVFGL-GGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECISP 242 Query: 201 RE-VNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG--GRVIVVGSR---GTIEI 254 ++ I ++ + + E++ ++ D H G +VVG + Sbjct: 243 KDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSAKMLTY 302 Query: 255 NPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHEN 314 +P + V ++++ + A + L +I P +K++E E Sbjct: 303 DPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLA--KKFDLDQLITHVLPFKKISEGFEL 360 Query: 315 IIHGSGATGKMILLL 329 + SG + + +L Sbjct: 361 L--NSGQSIRTVLTF 373 >3COS-A nrPDB Length = 381 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 65/380 (17%), Positives = 137/380 (36%), Gaps = 67/380 (17%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67 +A +E G P ++ ++ V PK H+V I++ A + + + + P Sbjct: 11 CKAAIAWEAGKPLCIE---EVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEGLA-FPV 66 Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISG-------------------------- 101 G + AG++E++G + K GD+V Sbjct: 67 IVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLKSPASD 126 Query: 102 -------------------------GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTA 136 +++Y + +D + K+ + + ++ +G + T Sbjct: 127 QQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTG 186 Query: 137 YRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAH 195 Y A I++A V G + V G GGVGL+A +A G +I+G E GA Sbjct: 187 YGAAINNAKVTPGSTCAVFGL-GGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGAT 245 Query: 196 EVFNHREV-NYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGG----RVIVVGSRG 250 + N R++ I ++ + + G+D ++ K + G I V + Sbjct: 246 DCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGVAAGS 305 Query: 251 -TIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVA 309 + + P + + + + + + + + L ++ P +K++ Sbjct: 306 KGLTVFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKN--KKFNLDALVTHTLPFDKIS 363 Query: 310 EAHENIIHGSGATGKMILLL 329 EA + + G + + IL+ Sbjct: 364 EAFD--LMNQGKSIRTILIF 381 >1PL8-A nrPDB Length = 356 Score = 223 bits (569), Expect = 7e-59, Method: Composition-based stats. Identities = 79/339 (23%), Positives = 134/339 (39%), Gaps = 47/339 (13%) Query: 18 GPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRS----GTYSRKPLLPYTPGSDV 73 GP L+L + +P P ++VL+++H+ G+ + + G + K P G + Sbjct: 15 GPGDLRLE-NYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKK--PMVLGHEA 71 Query: 74 AGVIEAVGDNASAFKKGDRVFTSSTI---------------------------SGGYAEY 106 +G +E VG + K GDRV G + Sbjct: 72 SGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRF 131 Query: 107 ALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAAC 166 YKLP+ + F++GA I P A V G VLV GA G +G+ Sbjct: 132 YKHNAAFCYKLPDNVTFEEGALI-EPLSVGIHACRR-GGVTLGHKVLVCGA-GPIGMVTL 188 Query: 167 QIARAYG-LKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGI--DIIIE 223 +A+A G +++ T + + GA V + + + +K G+ G ++ IE Sbjct: 189 LVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIE 248 Query: 224 MLANVN-LSKDLSLLSHGGRVIVVGSRGTIEINPRDTMA-KESSIIGVTLFSSTKEEFQQ 281 + + GG +++VG + P A +E I GV + +T Sbjct: 249 CTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNT----WP 304 Query: 282 YAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSG 320 A ++ A + +KP++ ++PLEK EA E G G Sbjct: 305 VAISMLASKSVN-VKPLVTHRFPLEKALEAFETFKKGLG 342 >4EYE-A nrPDB Length = 342 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 96/330 (29%), Positives = 158/330 (47%), Gaps = 11/330 (3%) Query: 4 GQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKP 63 G M+A++ GPE L + +D+ P + V++ V A GV + + G Y K Sbjct: 18 GPGSMKAIQAQSLSGPEGL-VYTDVETPGAGPNVVVVDVKAAGVCFPDYLMTKGEYQLKM 76 Query: 64 LLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDF 123 P+ PG + AGV+ + + S K GDRV + I GGYAE A + P +LD Sbjct: 77 EPPFVPGIETAGVVRSAPEG-SGIKPGDRVMAFNFI-GGYAERVAVAPSNILPTPPQLDD 134 Query: 124 KQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTE 183 + A+ Y T Y A ++AGE+VLV GA+GG+G AA QIA+ G K++ Sbjct: 135 AEAVALIANYHTMYFAYARRGQLRAGETVLVLGAAGGIGTAAIQIAKGMGAKVIAVVNRT 194 Query: 184 EGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRV 243 + V GA V E + +++ G G+D++++ + + L+ GR+ Sbjct: 195 AATEFVKSVGADIVL-PLEEGWAKAVREATGGAGVDMVVDPIGGPAFDDAVRTLASEGRL 253 Query: 244 IVVG--SRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGME---IGWLKPV 298 +VVG + G I + + +S+IGV + Y QAG+E ++P Sbjct: 254 LVVGFAAGGIPTIKVNRLLLRNASLIGVA-WGEFLRTHADYLYETQAGLEKLVAEGMRPP 312 Query: 299 IGSQYPLEKVAEAHENIIHGSGATGKMILL 328 + ++ PL + +A ++ G GKM+L+ Sbjct: 313 VSARIPLSEGRQALQDFADGK-VYGKMVLV 341 >1E3E-A nrPDB Length = 376 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 67/378 (17%), Positives = 133/378 (35%), Gaps = 66/378 (17%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67 +A ++ G P ++ +I V PK +V I+V A V P + +K L P Sbjct: 9 CKAAIAWKTGSPLCIE---EIEVSPPKACEVRIQVIATCVCPTDINAT--DPKKKALFPV 63 Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISG-------------------------- 101 G + AG++E+VG + FK GD+V Sbjct: 64 VLGHECAGIVESVGPGVTNFKPGDKVIPFFAPQCKRCKLCLSPLTNLCGKLRNFKYPTID 123 Query: 102 -------------------------GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTA 136 +++Y + ++ + ++ ++ + ++ IG + + Sbjct: 124 QELMEDRTSRFTCKGRSIYHFMGVSSFSQYTVVSEANLARVDDEANLERVCLIGCGFSSG 183 Query: 137 YRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAH 195 Y A I++A V G + V G G VGL+A + G +I+ E GA Sbjct: 184 YGAAINTAKVTPGSTCAVFGL-GCVGLSAIIGCKIAGASRIIAIDINGEKFPKAKALGAT 242 Query: 196 EVFNHREVN-YIDKIKKYVGEKGIDIIIEMLANVNLSKD---LSLLSHGGRVIVVGSRGT 251 + N RE++ + + + G+D ++ K ++L G +V Sbjct: 243 DCLNPRELDKPVQDVITELTAGGVDYSLDCAGTAQTLKAAVDCTVLGWGSCTVVGAKVDE 302 Query: 252 IEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEA 311 + I D + S + + + + + L ++ P E + +A Sbjct: 303 MTIPTVDVILGRSINGTFFGGWKSVDSVPNLVSDYKN--KKFDLDLLVTHALPFESINDA 360 Query: 312 HENIIHGSGATGKMILLL 329 + + G + + IL Sbjct: 361 IDLMKEGK--SIRTILTF 376 >1H2B-A nrPDB Length = 359 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 79/362 (21%), Positives = 153/362 (42%), Gaps = 48/362 (13%) Query: 2 ATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIP-KDHQVLIKVHACGVNPVETYIRSGTYS 60 + G + ++A R+ E+ P ++ D+ P V++++ GV + ++ G + Sbjct: 10 SLGVERLKAARLHEYNKPLRIE---DVDYPRLEGRFDVIVRIAGAGVCHTDLHLVQGMWH 66 Query: 61 --RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRV------------------------- 93 +P LPYT G + G IE V + +KGD V Sbjct: 67 ELLQPKLPYTLGHENVGYIEEVAEGVEGLEKGDPVILHPAVTDGTCLACRAGEDMHCENL 126 Query: 94 -FTSSTISGGYAEYALAADHTVYKLPEKLD---FKQGAAIGIPYFTAYRALIHSA-CVKA 148 F I GG+AE+ + +V KLP+ + + A + TAYRA+ +A + Sbjct: 127 EFPGLNIDGGFAEFMRTSHRSVIKLPKDISREKLVEMAPLADAGITAYRAVKKAARTLYP 186 Query: 149 GESVLVHGASGGVGLAACQIARAYG-LKILGTAGTEEGQKIVLQNGAHEVFNHREVNYID 207 G V + G GG+G A Q+ + ++ EE K+ + GA V + R + + Sbjct: 187 GAYVAIVG-VGGLGHIAVQLLKVMTPATVIALDVKEEKLKLAERLGADHVVDARR-DPVK 244 Query: 208 KIKKYVGEKGIDIIIEMLA-NVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSI 266 ++ + +G+++ ++ + + LL GR+I+VG G + ++ E S Sbjct: 245 QVMELTRGRGVNVAMDFVGSQATVDYTPYLLGRMGRLIIVGYGGELRFPTIRVISSEVSF 304 Query: 267 IGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMI 326 G + + E + ALQ G ++ + + L+++ + E + G G+ + Sbjct: 305 EGSLVG-NYVELHELVTLALQ-----GKVRVEVD-IHKLDEINDVLERLEKGE-VLGRAV 356 Query: 327 LL 328 L+ Sbjct: 357 LI 358 >3GFB-A nrPDB Length = 350 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 79/344 (22%), Positives = 139/344 (40%), Gaps = 42/344 (12%) Query: 18 GPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTY--SRKPLLPYTPGSDVAG 75 P ++ VP P +VLIKV A + + +I + P G +VAG Sbjct: 12 KPAYGAELVEVDVPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAG 71 Query: 76 VIEAVGDNASAFKKGDRVFTSSTI--------------------------SGGYAEYALA 109 + VG + GD + + I G +A YA+ Sbjct: 72 EVVEVGPGVEDLQVGDYISVETHIVCGKCYACKHNRYHVCQNTKIFGVDMDGVFAHYAIV 131 Query: 110 ADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIA 169 +K P+ + + AA+ P A ++ A AG S L+ GA G +GL +A Sbjct: 132 PAKNAWKNPKDMPP-EYAALQEPLGNAVDTVL--AGPIAGRSTLITGA-GPLGLLGIAVA 187 Query: 170 RAYGLK-ILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLA-N 227 +A G ++ + +E +K+ + GA V N E + + + G+++ +E Sbjct: 188 KASGAYPVIVSEPSEFRRKLAKKVGADYVVNPFEEDPVKFVMDITDGAGVEVFLEFSGAP 247 Query: 228 VNLSKDLSLLSHGGRVIVVGS-RGTIEIN-PRDTMAKESSIIGVTLFSSTKEEFQQYAAA 285 L + L ++ GGRV ++G + I+ + K + G+T E + ++ Sbjct: 248 KALEQGLKAVTPGGRVSLLGLFPREVTIDFNNLIIFKALEVHGIT-GRHLWETWYTVSSL 306 Query: 286 LQAGMEIGWLKPVIGSQYP-LEKVAEAHENIIHGSGATGKMILL 328 +Q+G L P+I +Y +K EA E + G TGK++ Sbjct: 307 IQSGKLN--LDPIITHKYKGFDKFEEAFELMRAGK--TGKVVFF 346 >3HZZ-A nrPDB Length = 467 Score = 221 bits (562), Expect = 5e-58, Method: Composition-based stats. Identities = 86/367 (23%), Positives = 140/367 (38%), Gaps = 71/367 (19%) Query: 26 SDIAVPIPKDHQVLIKVHACGVNPVETYI-------------RSGTYSR---KPLLPY-T 68 ++ VP + L+ V A VN + R G S + LPY Sbjct: 79 DEVPVPELGPGEALVAVMASSVNYNSVWTSIFEPVSTFAFLERYGKLSPLTKRHDLPYHI 138 Query: 69 PGSDVAGVIEAVGDNASAFKKGDRV--------------------------FTSSTISGG 102 GSD+AGV+ G +A++ GD V + T GG Sbjct: 139 IGSDLAGVVLRTGPGVNAWQPGDEVVAHCLSVELESPDGHDDTMLDPEQRIWGFETNFGG 198 Query: 103 YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALI--HSACVKAGESVLVHGASGG 160 AE AL + + P+ L +++ AA G+ TAYR L+ + A +K G++VL+ GASGG Sbjct: 199 LAEIALVKTNQLMPKPKHLTWEEAAAPGLVNSTAYRQLVSRNGAAMKQGDNVLIWGASGG 258 Query: 161 VGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVN---------------- 204 +G A Q A A G + + + +I GA + + Sbjct: 259 LGSYATQFALAGGANPICVVSSPQKAEICRSMGAEAIIDRNAEGYKFWKDEHTQDPKEWK 318 Query: 205 -YIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTI--EINPRDTMA 261 + +I++ G + IDI+ E + + GG + S E + R Sbjct: 319 RFGKRIRELTGGEDIDIVFEHPGRETFGASVYVTRKGGTITTCASTSGYMHEYDNRYLWM 378 Query: 262 KESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGA 321 IIG F++ +E A + G + P + Y LE+ +A ++ Sbjct: 379 SLKRIIGS-HFANYRE-----AYEANRLIAKGKIHPTLSKTYSLEETGQAAYDVHRNLHQ 432 Query: 322 TGKMILL 328 GK+ +L Sbjct: 433 -GKVGVL 438 >4Y1B-A nrPDB Length = 425 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 79/396 (19%), Positives = 148/396 (37%), Gaps = 74/396 (18%) Query: 1 MATGQKLMRA--VRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGT 58 + T K M A +R +G P + VP QVL+KV A GVN + G Sbjct: 34 LGTAPKQMYASLIRQERYGRPVDAFRTEVVDVPPVGPGQVLVKVMAAGVNYNNVWAALGE 93 Query: 59 Y---------SRKPLLPYTPGSDVAGVIEAVGDNASAFKKG------------------- 90 + GSD++G++ AVGD K G Sbjct: 94 PLDVIAARQKQGATEDFHIGGSDLSGIVWAVGDGV-RLKPGAEVVVLACRWDESAQDIRL 152 Query: 91 ---------DRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALI 141 RV+ G +A++A+ ++ + P++L + + TAYR L Sbjct: 153 GADPVTSSTQRVWGYEENYGSFAQFAVVDEYMCHPKPQRLSWAAASCYMATAATAYRQLF 212 Query: 142 --HSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFN 199 V+ G+ VL+ G +GG+G A Q+ R G + +EE + ++ GA + Sbjct: 213 GWEPHTVRPGDPVLIWGGAGGLGSIAIQLVRHVGGIPVAVVSSEERGEFCMRLGAKGWID 272 Query: 200 HREVNYIDKIKKYVGEKGID------------------------IIIEMLANVNLSKDLS 235 RE ++ ++ E+ + I++E + + Sbjct: 273 RREFDHWGRLPDTTDEEAMKQWLDGARAFGRRFWEVLGERRAPRIVLEHSGADTIPTSIY 332 Query: 236 LLSHGGRVIVVGSRGTI--EINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIG 293 + + G V++ G +++ R ++ + G +S +E A + ++ G Sbjct: 333 MADNAGMVVICGGTTGYNGDVDLRFLWMRQKRLQGS-HAASARE-----AREITRLIDQG 386 Query: 294 WLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 + P + + E++ AH+ I +G M +L+ Sbjct: 387 AIDPCLSRTFGFEEIGLAHQLIHDNQHPSGNMAVLV 422 >5ENV-A nrPDB Length = 347 Score = 217 bits (553), Expect = 5e-57, Method: Composition-based stats. Identities = 80/353 (22%), Positives = 139/353 (39%), Gaps = 42/353 (11%) Query: 5 QKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPL 64 + + V +E G K DI VP PK +++LI V GV + + G + Sbjct: 3 PETQKGVIFYESHGKLEYK---DIPVPKPKANELLINVKYSGVCHTDLHAWHGDWPLPVK 59 Query: 65 LPYTPGSDVAGVIEAVGDNASAFKKGDRV---------------------------FTSS 97 LP G + AGV+ +G+N +K GD + Sbjct: 60 LPLVGGHEGAGVVVGMGENVKGWKIGDYAGIKWLNGSCMACEYCELGNESNCPHADLSGY 119 Query: 98 TISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGA 157 T G + +YA A +P+ D Q A I T Y+AL SA + AG V + GA Sbjct: 120 THDGSFQQYATADAVQAAHIPQGTDLAQVAPILCAGITVYKAL-KSANLMAGHWVAISGA 178 Query: 158 SGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFN-HREVNYIDKIKKYVGEK 216 +GG+G A Q A+A G ++LG G E +++ G + +E + + + K Sbjct: 179 AGGLGSLAVQYAKAMGYRVLGIDGGEGKEELFRSIGGEVFIDFTKEKDIVGAVLKATDGG 238 Query: 217 GIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIE--INPRDTMAKESSIIGVTLFSS 274 +I ++ + + G ++VG + + + + K SI+G + Sbjct: 239 AHGVINVSVSEAAIEASTRYVRANGTTVLVGMPAGAKCCSDVFNQVVKSISIVGS--YVG 296 Query: 275 TKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 + + ++ G+ +K V S P E +E + G G+ ++ Sbjct: 297 NRADTREALDFFARGLVKSPIKVVGLSTLP-----EIYEKMEKGQ-IVGRYVV 343 >3QE3-A nrPDB Length = 355 Score = 216 bits (549), Expect = 1e-56, Method: Composition-based stats. Identities = 79/339 (23%), Positives = 130/339 (38%), Gaps = 47/339 (13%) Query: 18 GPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRS----GTYSRKPLLPYTPGSDV 73 GP L+L + +P P ++VL+K+H+ G+ + + G + K P G + Sbjct: 14 GPGDLRLE-NYPIPEPGPNEVLLKMHSVGICGSDVHYWQHGRIGDFVVKK--PMVLGHEA 70 Query: 74 AGVIEAVGDNASAFKKGDRVFTSSTI---------------------------SGGYAEY 106 +G + VG + GDRV G + Sbjct: 71 SGTVVKVGSLVRHLQPGDRVAIQPGAPRQTDEFCKIGRYNLSPTIFFCATPPDDGNLCRF 130 Query: 107 ALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAAC 166 + YKLP+ + F++GA I P A A V G VLV GA G +GL Sbjct: 131 YKHNANFCYKLPDNVTFEEGALI-EPLSVGIHACRR-AGVTLGNKVLVCGA-GPIGLVNL 187 Query: 167 QIARAYG-LKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVG--EKGIDIIIE 223 A+A G +++ T + + GA + + + KK G ++ IE Sbjct: 188 LAAKAMGAAQVVVTDLSASRLSKAKEVGADFILEISNESPEEIAKKVEGLLGSKPEVTIE 247 Query: 224 MLANVN-LSKDLSLLSHGGRVIVVGSRGTIEINPRDTMA-KESSIIGVTLFSSTKEEFQQ 281 + + GG +++VG + P A +E I GV + +T Sbjct: 248 CTGVETSIQAGIYATHSGGTLVLVGLGSEMTSVPLVHAATREVDIKGVFRYCNT----WP 303 Query: 282 YAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSG 320 A ++ A + +KP++ ++PLEK EA E G G Sbjct: 304 MAISMLASKSVN-VKPLVTHRFPLEKALEAFETSKKGLG 341 >4RQU-A nrPDB Length = 375 Score = 216 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 66/367 (17%), Positives = 130/367 (35%), Gaps = 62/367 (16%) Query: 7 LMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLP 66 +A +E G P V++ ++ V P+ H+V IK+ + + Y + PL P Sbjct: 5 RCKAAVAWEAGKPLVIE---EVEVAPPQKHEVRIKILFTSLCHTDVYFWEAK-GQTPLFP 60 Query: 67 YTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGG------------------------ 102 G + G++E+VG+ + + GD V T G Sbjct: 61 RIFGHEAGGIVESVGEGVTDLQPGDHVLPIFTGECGECRHCHSEESNMCDLLRINTERGG 120 Query: 103 ------------------------YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYR 138 ++EY + V K+ + + T Sbjct: 121 MIHDGESRFSINGKPIYHFLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLG 180 Query: 139 ALIHSACVKAGESVLVHGASGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEV 197 A ++ A K G+SV + G G VGL A + AR G +I+G + + G E Sbjct: 181 ATLNVAKPKKGQSVAIFGL-GAVGLGAAEGARIAGASRIIGVDFNSKRFDQAKEFGVTEC 239 Query: 198 FNHREVN-YIDKIKKYVGEKGIDIIIEMLANV-NLSKDLSLLSHG-GRVIVVGSRGT--- 251 N ++ + I ++ + + G+D +E +V + + + G G ++VG Sbjct: 240 VNPKDHDKPIQQVIAEMTDGGVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDDA 299 Query: 252 IEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEA 311 + +P + + + + K + + L+ I P ++ +A Sbjct: 300 FKTHPMNFLNERTLKGTFFGNYKPKTDIPGVVEKYMN--KELELEKFITHTVPFSEINKA 357 Query: 312 HENIIHG 318 + ++ G Sbjct: 358 FDYMLKG 364 >4EEZ-A nrPDB Length = 348 Score = 214 bits (546), Expect = 3e-56, Method: Composition-based stats. Identities = 76/350 (21%), Positives = 153/350 (43%), Gaps = 44/350 (12%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67 M+A V P+ + + K ++ L+ + CGV + ++ +G + K Sbjct: 1 MKAAVVRH--NPDGYADLVEKELRAIKPNEALLDMEYCGVCHTDLHVAAGDFGNKAG--T 56 Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRV---------------------------FTSSTIS 100 G + G+++ +G + S+ + GDRV ++ Sbjct: 57 VLGHEGIGIVKEIGADVSSLQVGDRVSVAWFFEGCGHCEYCVSGNETFCREVKNAGYSVD 116 Query: 101 GGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGG 160 GG AE A+ K+P+ LD + ++I T Y+A+ + VK G+ ++ GA GG Sbjct: 117 GGMAEEAIVVADYAVKVPDGLDPIEASSITCAGVTTYKAI-KVSGVKPGDWQVIFGA-GG 174 Query: 161 VGLAACQIAR-AYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGI- 218 +G A Q A+ +G K++ ++ + + GA N +VN +D+IKK G G+ Sbjct: 175 LGNLAIQYAKNVFGAKVIAVDINQDKLNLAKKIGADVTINSGDVNPVDEIKKITGGLGVQ 234 Query: 219 DIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGT-IEINPRDTMAKESSIIGVTLFSSTKE 277 I+ +A + + ++ L G+++ V T + ++ + + G + + Sbjct: 235 SAIVCAVARIAFEQAVASLKPMGKMVAVAVPNTEMTLSVPTVVFDGVEVAGSLVGTR--- 291 Query: 278 EFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 A A Q G E G +KP++ ++ LE++ + + + G G+M++ Sbjct: 292 --LDLAEAFQFGAE-GKVKPIVATR-KLEEINDIIDEMKAGK-IEGRMVI 336 >5YAT-A nrPDB Length = 350 Score = 213 bits (543), Expect = 7e-56, Method: Composition-based stats. Identities = 80/353 (22%), Positives = 147/353 (41%), Gaps = 38/353 (10%) Query: 3 TGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRK 62 T +AV GGP K DI VP PK +++LI V GV + + G + Sbjct: 4 TIPTTQKAVIFETNGGPLEYK---DIPVPKPKSNELLINVKYSGVCHTDLHAWKGDWPLD 60 Query: 63 PLLPYTPGSDVAGVIEAVGDNASAFKKGDRV---------------------------FT 95 LP G + AGV+ A G+N + ++ GD + Sbjct: 61 NKLPLVGGHEGAGVVVAYGENVTGWEIGDYAGIKWLNGSCLNCEYCIQGAESSCAKADLS 120 Query: 96 SSTISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVH 155 T G + +YA A ++P++ D + A I T Y+AL +A ++ G+ V + Sbjct: 121 GFTHDGSFQQYATADATQAARIPKEADLAEVAPILCAGITVYKAL-KTADLRIGQWVAIS 179 Query: 156 GASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFN-HREVNYIDKIKKYVG 214 GA GG+G A Q A+A GL++LG G + + V GA + + + + +++K Sbjct: 180 GAGGGLGSLAVQYAKALGLRVLGIDGGADKGEFVKSLGAEVFVDFTKTKDVVAEVQKLTN 239 Query: 215 EKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSS 274 +I ++ +++ + + G+V++VG +N SI + Sbjct: 240 GGPHGVINVSVSPHAINQSVQYVRTLGKVVLVGLPSGAVVNSDVFWHVLKSIEIKGSYVG 299 Query: 275 TKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 +E+ + G+ +K + L ++A+ +E + G G+ ++ Sbjct: 300 NREDSAEAIDLFTRGLVKAPIKII-----GLSELAKVYEQMEAG-AIIGRYVV 346 >4A10-A nrPDB Length = 447 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 85/366 (23%), Positives = 131/366 (35%), Gaps = 71/366 (19%) Query: 27 DIAVPIPKDHQVLIKVHACGVNPVETY----------------IRSGTYSRKPLLPY-TP 69 ++ +P +VL+ V A +N + R G ++ + PY Sbjct: 54 EVPMPELAPDEVLVAVMASSINYNTVWSAMFEPIPTFHFLKQNARQGGWATRHDQPYHVL 113 Query: 70 GSDVAGVIEAVGDNASAFKKGDRV--------------------------FTSSTISGGY 103 GSD +GV+ G +K GD V + T GG Sbjct: 114 GSDCSGVVVRTGIGVRRWKPGDHVIVHPAHVDEQEPATHGDGMLGTEQRAWGFETNFGGL 173 Query: 104 AEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALI--HSACVKAGESVLVHGASGGV 161 AEY + + P L +++ A + TAYR L+ A +K G+ VL+ GASGG+ Sbjct: 174 AEYGVVRASQLLPKPAHLTWEEAAVSPLCAGTAYRMLVSDRGAQMKQGDIVLIWGASGGL 233 Query: 162 GLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKK---------- 211 G A Q + G + + + + V G V N E+ D I Sbjct: 234 GSYAIQFVKNGGGIPVAVVSSAQKEAAVRALGCDLVINRAELGITDDIADDPRRVVETGR 293 Query: 212 -------YVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTI--EINPRDTMAK 262 + DI+ E V + + GG V+ GS + R K Sbjct: 294 KLAKLVVEKAGREPDIVFEHTGRVTFGLSVIVARRGGTVVTCGSSSGYLHTFDNRYLWMK 353 Query: 263 ESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGAT 322 I+G E QQ L E G + P + + YPL + AEA ++ S Sbjct: 354 LKKIVGS---HGANHEEQQATNRLF---ESGAVVPAMSAVYPLAEAAEAC-RVVQTSRQV 406 Query: 323 GKMILL 328 GK+ +L Sbjct: 407 GKVAVL 412 >4DLA-A nrPDB Length = 396 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 70/367 (19%), Positives = 130/367 (35%), Gaps = 62/367 (16%) Query: 7 LMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLP 66 +A +E P V++ D+ V P+ +V +KV + + Y SG + L P Sbjct: 26 TCKAAVAWEPNKPLVIE---DVQVAPPQAGEVRVKVLYTALCHTDAYTWSGK-DPEGLFP 81 Query: 67 YTPGSDVAGVIEAVGDNASAFKKGDRVFTSS----------------------------- 97 G + AG++E+VG+ + + GD V Sbjct: 82 CVLGHEAAGIVESVGEGVTEVQPGDHVIPCYQAECRECKFCKSGKTNLCGKVRAATGVGV 141 Query: 98 ---------TISG----------GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYR 138 +I+G +++Y + D +V K+ ++ +G T Sbjct: 142 MMNDRKSRFSINGKPIYHFMGTSTFSQYTVVHDVSVAKIDPVAPLEKVCLLGCGVPTGLG 201 Query: 139 ALIHSACVKAGESVLVHGASGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEV 197 A+ ++A V+ G V V G G VGLA + A+A G +I+G + G E Sbjct: 202 AVWNTAKVEPGSIVAVFGL-GTVGLAVAEGAKAAGASRIIGIDIDSKKFDRAKNFGVTEF 260 Query: 198 FNHRE-VNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG--GRVIVVG---SRGT 251 N +E I ++ + + G+D E + NV++ + H G ++VG S Sbjct: 261 INPKEHEQPIQQVIVDLTDGGVDYSFECIGNVSVMRSALECCHKGWGTSVIVGVAASGQE 320 Query: 252 IEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEA 311 I P + ++ + + + I L + +A Sbjct: 321 ISTRPFQLVTGRVWKGTAFGGFKSRSQVPSLVDKY--LKKEIKVDEYITHNMTLADINKA 378 Query: 312 HENIIHG 318 + + G Sbjct: 379 FDLMHDG 385 >5A3V-A nrPDB Length = 329 Score = 210 bits (536), Expect = 5e-55, Method: Composition-based stats. Identities = 97/333 (29%), Positives = 152/333 (45%), Gaps = 20/333 (6%) Query: 6 KLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSR--KP 63 KLM A++ +GG + VP PK ++V +K+ A +NPV+ I+ G Sbjct: 4 KLMHALQYNSYGGGAAGLEHVQVPVPTPKSNEVCLKLEATSLNPVDWKIQKGMIRPFLPR 63 Query: 64 LLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTI--SGGYAEYALAADHTVYKLPEKL 121 P P +DVAG + VG FK GD+V + GG AE+A+A + K P+++ Sbjct: 64 KFPCIPATDVAGEVVEVGSGVKNFKAGDKVVAVLSHLGGGGLAEFAVATEKLTVKRPQEV 123 Query: 122 DFKQGAAIGIPYFTAYRALIHSACVK---AGE--SVLVHGASGGVGLAACQIARAYGLKI 176 + AA+ + TA +AL + A +K G+ ++LV ASGGVG A Q+A+ + Sbjct: 124 GAAEAAALPVAGLTALQALTNPAGLKLDGTGKKANILVTAASGGVGHYAVQLAKLANAHV 183 Query: 177 LGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSL 236 T G + V GA EV +++ K K D ++ + S Sbjct: 184 TATCG-ARNIEFVKSLGADEVLDYKT--PEGAALKSPSGKKYDAVVHCANGIPFSVFEPN 240 Query: 237 LSHGGRVIVV--GSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGW 294 LS G+VI + G + + + V L K E ++ L ++ G Sbjct: 241 LSENGKVIDITPGPNAMWTYAVKKITMSKKQL--VPLLLIPKAENLEFMVNL---VKEGK 295 Query: 295 LKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 +K VI S++PL K +A I G ATGK+I+ Sbjct: 296 VKTVIDSKHPLSKAEDAWAKSIDGH-ATGKIIV 327 >2DQ4-A nrPDB Length = 343 Score = 210 bits (535), Expect = 6e-55, Method: Composition-based stats. Identities = 81/340 (23%), Positives = 137/340 (40%), Gaps = 40/340 (11%) Query: 19 PEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGT-YSRKP-LLPYTPGSDVAGV 76 PE D VP P ++L++V A + + +I ++R P G + +GV Sbjct: 9 PEEGLTLVDRPVPEPGPGEILVRVEAASICGTDLHIWKWDAWARGRIRPPLVTGHEFSGV 68 Query: 77 IEAVGDNASAFKKGDRVFTSSTI--------------------------SGGYAEYALAA 110 +EAVG + GD V S I GG+AEY + Sbjct: 69 VEAVGPGVRRPQVGDHVSLESHIVCHACPACRTGNYHVCLNTQILGVDRDGGFAEYVVVP 128 Query: 111 DHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIAR 170 + P+ L F + AAI P+ A + + V G+SVL+ GA G +GL A + R Sbjct: 129 AENAWVNPKDLPF-EVAAILEPFGNAVHTVYAGSGVS-GKSVLITGA-GPIGLMAAMVVR 185 Query: 171 AYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANV-N 229 A G + + + + A + N E + ++ +++ G G+++++E N Sbjct: 186 ASGAGPILVSDPNPYRLAFARPYADRLVNPLEEDLLEVVRRVTGS-GVEVLLEFSGNEAA 244 Query: 230 LSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAG 289 + + L L GG ++G R +A E + G+T F Q A Sbjct: 245 IHQGLMALIPGGEARILGIPSD---PIRFDLAGELVMRGITAFGIAGRRLWQTWMQGTAL 301 Query: 290 MEIGWLK--PVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 + G + P++ + PL + EA + G K+IL Sbjct: 302 VYSGRVDLSPLLTHRLPLSRYREAFGLLASGQAV--KVIL 339 >2VCY-A nrPDB Length = 344 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 71/338 (21%), Positives = 141/338 (41%), Gaps = 11/338 (3%) Query: 2 ATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSR 61 + +RA+ G P + ++ + + V +K+ A +NP + + G Y Sbjct: 8 SAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGL 67 Query: 62 KPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKL 121 P LP G++ + AVG N + K GD V ++ G + A+ ++ + ++P + Sbjct: 68 LPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDI 127 Query: 122 DFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAG 181 + A +G+ TAYR L+ ++ G+SV+ + ++ GVG A QIA A GL+ + Sbjct: 128 PLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVR 187 Query: 182 T----EEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLL 237 ++ + GA V E+ + + + + + + ++ L L Sbjct: 188 DRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQL 247 Query: 238 SHGGRVIVVGSRGTIEI--NPRDTMAKESSIIGVTL----FSSTKEEFQQYAAALQAGME 291 + GG ++ G + + + K+ + G L + ++F++ L + Sbjct: 248 ARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIR 307 Query: 292 IGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 G L SQ PL+ A E + + K IL + Sbjct: 308 RGQLTAPACSQVPLQDYQSALEASMKPF-ISSKQILTM 344 >1CDO-A nrPDB Length = 374 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 73/376 (19%), Positives = 138/376 (36%), Gaps = 64/376 (17%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVET-YIRSGTYSRKPLLP 66 +A +E P V++ +I V +P +++ IK+ A GV + ++ G + K P Sbjct: 9 CKAAVAWEANKPLVIE---EIEVDVPHANEIRIKIIATGVCHTDLYHLFEGKH--KDGFP 63 Query: 67 YTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGG------------------------ 102 G + AG++E+VG + F+ G++V G Sbjct: 64 VVLGHEGAGIVESVGPGVTEFQPGEKVIPLFISQCGECRFCQSPKTNQCVKGWANESPDV 123 Query: 103 -----------------------YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRA 139 +++Y + V K+ +G T + A Sbjct: 124 MSPKETRFTCKGRKVLQFLGTSTFSQYTVVNQIAVAKIDPSAPLDTVCLLGCGVSTGFGA 183 Query: 140 LIHSACVKAGESVLVHGASGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEVF 198 +++A V+ G + V G G VGLAA + G +I+ + + GA + Sbjct: 184 AVNTAKVEPGSTCAVFGL-GAVGLAAVMGCHSAGAKRIIAVDLNPDKFEKAKVFGATDFV 242 Query: 199 NHRE-VNYIDKIKKYVGEKGIDIIIEMLANVNLSKDL--SLLSHGGRVIVVGSRG--TIE 253 N + I ++ + G+D +E + NV + ++ S L G ++VG + Sbjct: 243 NPNDHSEPISQVLSKMTNGGVDFSLECVGNVGVMRNALESCLKGWGVSVLVGWTDLHDVA 302 Query: 254 INPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHE 313 P +A + + K+ + A + L I + PLE V +A + Sbjct: 303 TRPIQLIAGRTWKGSMFGGFKGKDGVPKMVKAYLD--KKVKLDEFITHRMPLESVNDAID 360 Query: 314 NIIHGSGATGKMILLL 329 + HG + +L L Sbjct: 361 LMKHGKCI--RTVLSL 374 >5VM2-A nrPDB Length = 347 Score = 207 bits (526), Expect = 7e-54, Method: Composition-based stats. Identities = 71/342 (20%), Positives = 136/342 (39%), Gaps = 42/342 (12%) Query: 19 PEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLP---YTPGSDVAG 75 P +K+ +P+PK+ +VLIKV G+ + + P P G + AG Sbjct: 11 PGTMKI-ISAEIPVPKEDEVLIKVEYVGICGSDVHGFESGPFIPPKDPNQEIGLGHECAG 69 Query: 76 VIEAVGDNASAFKKGDRVFTSSTISGGYAEYAL--------------------------- 108 + AVG FK GDRV + G+ Y L Sbjct: 70 TVVAVGSRVRKFKPGDRVNIEPGVPCGHCRYCLEGKYNICPDVDFMATQPNYRGALTHYL 129 Query: 109 -AADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQ 167 + YKLP+ +D +G + + A++ A VK G+ +++ GA G +GL Q Sbjct: 130 CHPESFTYKLPDNMDTMEGTLVEPAAVGMHAAML--ADVKPGKKIIILGA-GCIGLMTLQ 186 Query: 168 IARAYGLKILGTAGTEEGQ-KIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLA 226 + G + E + + Q GA V N + + I + +++ + G DI+ E Sbjct: 187 ACKCLGATEIAVVDVLEKRLAMAEQLGATVVINGAKEDTIARCQQFTEDMGADIVFETAG 246 Query: 227 NV-NLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAA 285 + + + L+ GG++++VG+ + +E +I V +++ + ++ Sbjct: 247 SAVTVKQAPYLVMRGGKIMIVGTVPGASAINFLKINREVTIQTVFRYANRYPVTIEAISS 306 Query: 286 LQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 + +K ++ Y V +A E ++ K ++ Sbjct: 307 GR-----FDVKSMVTHIYDYRDVQQAFEESVNNKRDIIKGVI 343 >4JJI-A nrPDB Length = 378 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 65/367 (17%), Positives = 130/367 (35%), Gaps = 62/367 (16%) Query: 7 LMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLP 66 +A +E P V++ D+ V P+ +V IK+ + + Y SG + L P Sbjct: 8 TCKAAVAYEPNKPLVIE---DVQVAPPQAGEVRIKILYTALCHTDAYTWSGK-DPEGLFP 63 Query: 67 YTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISG------------------------- 101 G + AG++E+VG+ + + GD V Sbjct: 64 CILGHEAAGIVESVGEGVTEVQAGDHVIPCYQAECRECKFCKSGKTNLCGKVRSATGVGI 123 Query: 102 -----------------------GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYR 138 +++Y + D +V K+ + +G T Sbjct: 124 MMNDRKSRFSVNGKPIYHFMGTSTFSQYTVVHDVSVAKIDPTAPLDKVCLLGCGVPTGLG 183 Query: 139 ALIHSACVKAGESVLVHGASGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEV 197 A+ ++A V+ G +V + G G VGLA + A+ G +I+G + + + G +E Sbjct: 184 AVWNTAKVEPGSNVAIFGL-GTVGLAVAEGAKTAGASRIIGIDIDSKKYETAKKFGVNEF 242 Query: 198 FNHREVN-YIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG--GRVIVVG---SRGT 251 N ++ + I ++ + + G+D E + NV++ + H G ++VG S Sbjct: 243 VNPKDHDKPIQEVIVDLTDGGVDYSFECIGNVSVMRAALECCHKGWGTSVIVGVAASGQE 302 Query: 252 IEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEA 311 I P + ++ + + + I L ++ +A Sbjct: 303 ISTRPFQLVTGRVWKGTAFGGFKSRTQVPWLVEKYMN--KEIKVDEYITHNLTLGEINKA 360 Query: 312 HENIIHG 318 + + G Sbjct: 361 FDLLHEG 367 >1E3J-A nrPDB Length = 352 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 74/348 (21%), Positives = 143/348 (41%), Gaps = 50/348 (14%) Query: 18 GPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYI----RSGTYSRKPLLPYTPGSDV 73 L+L +P PK+ +VL+++ G+ + + R + K P G + Sbjct: 12 KQNDLRLEQ-RPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVK--DPMVIGHEA 68 Query: 74 AGVIEAVGDNASAFKKGDRVFTSSTI---------------------------SGGYAEY 106 +G + VG N KKGDRV + G A Y Sbjct: 69 SGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLCPDLTFCATPPDDGNLARY 128 Query: 107 ALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAAC 166 + A +KLP+ + ++GA + P A A V+ G +VLV GA G +GL + Sbjct: 129 YVHAADFCHKLPDNVSLEEGALL-EPLSVGVHACRR-AGVQLGTTVLVIGA-GPIGLVSV 185 Query: 167 QIARAYGLKILGTAGTEEGQKIVLQNGAHE--VFNHREVN---YIDKIKKYVGEKGIDII 221 A+AYG ++ TA + ++ GA V + + I++I+ +G+ ++ Sbjct: 186 LAAKAYGAFVVCTARSPRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAIGDLP-NVT 244 Query: 222 IEMLANVN-LSKDLSLLSHGGRVIVVGSRGT-IEINPRDTMAKESSIIGVTLFSSTKEEF 279 I+ N ++ +++ GG +++VG + + + A+E I V + + Sbjct: 245 IDCSGNEKCITIGINITRTGGTLMLVGMGSQMVTVPLVNACAREIDIKSVFRYCNDYPIA 304 Query: 280 QQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 + A+ + +K ++ + LE+ +A E + T K+++ Sbjct: 305 LEMVASGRCN-----VKQLVTHSFKLEQTVDAFEAARKKADNTIKVMI 347 >2WEK-A nrPDB Length = 341 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 75/347 (21%), Positives = 141/347 (40%), Gaps = 31/347 (8%) Query: 6 KLMRAVRVFEFGGP--EVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKP 63 +M+ + V E + L D VP+P D +L++ GVN + +G Y Sbjct: 1 SMMQKLVVTRLSPNFREAVTLSRDCPVPLPGDGDLLVRNRFVGVNASDINYSAGRYDPSV 60 Query: 64 LLPYTPGSDVAGVIEAVGDNAS-AFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLD 122 P+ G + G + A+G +AS + G V + G +AEY + +P Sbjct: 61 KPPFDIGFEGIGEVVALGLSASARYTVGQAV--AYMAPGSFAEYTVVPASIATPVPSVKP 118 Query: 123 FKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGT 182 + + + TAY +L + G+ VLV A+GG G A Q+++ ++GT + Sbjct: 119 --EYLTLLVSGTTAYISLKELGGLSEGKKVLVTAAAGGTGQFAMQLSKKAKCHVIGTCSS 176 Query: 183 EEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGR 242 +E + G N++ + + K +G+D++ E + + L+ GR Sbjct: 177 DEKSAFLKSLGCDRPINYKTE-PVGTVLKQEYPEGVDVVYESVGGAMFDLAVDALATKGR 235 Query: 243 VIVVGSRGTIEIN-----------PRDTMAKESSIIGVTL------FSSTKEEFQQY--A 283 +IV+G + P + K +S+ G L + + + + Sbjct: 236 LIVIGFISGYQTPTGLSPVKAGTLPAKLLKKSASVQGFFLNHYLSKYQAAMSHLLEMCVS 295 Query: 284 AALQAGMEIGWLKPVIGSQY-PLEKVAEAHENIIHGSGATGKMILLL 329 L +++G L P ++ LE + A + G TGK+++ L Sbjct: 296 GDLVCEVDLGDLSP--EGRFTGLESIFRAVNYMYMGKN-TGKIVVEL 339 >1V3V-A nrPDB Length = 333 Score = 203 bits (517), Expect = 7e-53, Method: Composition-based stats. Identities = 77/321 (23%), Positives = 133/321 (41%), Gaps = 18/321 (5%) Query: 17 GGPEVLKLRSD-IAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAG 75 G P + +P K+ +VL++ V+P Y+R + R G VA Sbjct: 19 GKPTQSDFELKTVELPPLKNGEVLLEALFLSVDP---YMRIAS-KRLKEGAVMMGQQVAR 74 Query: 76 VIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQG-AAIGIPYF 134 V+E SAF G V S + + + + + P+KL IG+P Sbjct: 75 VVE---SKNSAFPAGSIVLAQSGWTTHFISDGKGLEKLLTEWPDKLPLSLALGTIGMPGL 131 Query: 135 TAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGA 194 TAY L+ VK GE+VLV A+G VG QIA+ G K++G AG++E + Q G Sbjct: 132 TAYFGLLEVCGVKGGETVLVSAAAGAVGSVVGQIAKLKGCKVVGAAGSDEKIAYLKQIGF 191 Query: 195 HEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEI 254 FN++ VN +++ K G D + + L+ LS + G++ + G+ Sbjct: 192 DAAFNYKTVNSLEEALKKASPDGYDCYFDNVGGEFLNTVLSQMKDFGKIAICGAISVYNR 251 Query: 255 --------NPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLE 306 +P + K+ I G ++ + ++ L + G ++ E Sbjct: 252 MDQLPPGPSPESIIYKQLRIEGFIVYRWQGDVREKALRDLMKWVLEGKIQYHEHVTKGFE 311 Query: 307 KVAEAHENIIHGSGATGKMIL 327 + A +++G GK ++ Sbjct: 312 NMPAAFIEMLNG-ANLGKAVV 331 >3SLK-A nrPDB Length = 795 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 80/320 (25%), Positives = 138/320 (43%), Gaps = 10/320 (3%) Query: 11 VRVFEFGGPEVLKLRSD-IAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTP 69 + G + L L + A D +V I + A GVN + I G Y Sbjct: 213 LEATRPGSLDGLALVDEPTATAPLGDGEVRIAMRAAGVNFRDALIALGMYPGVAS----L 268 Query: 70 GSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQGAAI 129 GS+ AGV+ G + GDRV I + A+A V ++P F + A++ Sbjct: 269 GSEGAGVVVETGPGVTGLAPGDRVMG--MIPKAFGPLAVADHRMVTRIPAGWSFARAASV 326 Query: 130 GIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIV 189 I + TAY AL+ A ++ GES+LVH A+GGVG+AA Q+AR G ++ TA ++ Q Sbjct: 327 PIVFLTAYYALVDLAGLRPGESLLVHSAAGGVGMAAIQLARHLGAEVYATASEDKWQ--A 384 Query: 190 LQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSR 249 ++ + + R ++ + G +G+D+++ LA L +L GGR + +G Sbjct: 385 VELSREHLASSRTCDFEQQFLGATGGRGVDVVLNSLAGEFADASLRMLPRGGRFLELGKT 444 Query: 250 GTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVA 309 + S + + + L E L+P+ + + + + Sbjct: 445 DVRDPVEVADAHPGVSYQAFDTVEAGPQRIGEMLHELVELFEGRVLEPLPVTAWDVRQAP 504 Query: 310 EAHENIIHGSGATGKMILLL 329 EA ++ GK++L + Sbjct: 505 EALRHLSQARH-VGKLVLTM 523 >2H6E-A nrPDB Length = 344 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 77/352 (21%), Positives = 142/352 (40%), Gaps = 47/352 (13%) Query: 9 RAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPL-LPY 67 +A + +F P ++ D+ +P P+ +VLI++ GV + + G +++ LP Sbjct: 5 KAALLKKFSEPLSIE---DVNIPEPQGEEVLIRIGGAGVCRTDLRVWKGVEAKQGFRLPI 61 Query: 68 TPGSDVAGVIEAVGDNASAFKKGDRVF--------------------------TSSTISG 101 G + AG I VG+ A KKGD V T +G Sbjct: 62 ILGHENAGTIVEVGELAK-VKKGDNVVVYATWGDLTCRYCREGKFNICKNQIIPGQTTNG 120 Query: 102 GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSAC--VKAGESVLVHGASG 159 G++EY L L + A + T+ A+ + K E V++ G Sbjct: 121 GFSEYMLVKSSRWLVKLNSLSPVEAAPLADAGTTSMGAIRQALPFISKFAEPVVIVNGIG 180 Query: 160 GVGLAACQIARAY--GLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKG 217 G+ + QI +A + I+G + +++ + L+ GA V ++ + I K G Sbjct: 181 GLAVYTIQILKALMKNITIVGISRSKKHRDFALELGADYVSEMKDAESL--INKLTDGLG 238 Query: 218 IDIIIEMLANVNLSKDL-SLLSHGGRVIVVGSRGT-IEINPRDTMAKESSIIGVTLFSST 275 I I+++ + +L LL+ G +I+VG G + + DT ++G + Sbjct: 239 ASIAIDLVGTEETTYNLGKLLAQEGAIILVGMEGKRVSLEAFDTAVWNKKLLGSN--YGS 296 Query: 276 KEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 + + E G +KP I PL+ + +A N+ G G+ ++ Sbjct: 297 LNDLEDVV----RLSESGKIKPYIIKV-PLDDINKAFTNLDEGR-VDGRQVI 342 >1F8F-A nrPDB Length = 371 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 72/343 (20%), Positives = 130/343 (37%), Gaps = 61/343 (17%) Query: 30 VPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKK 89 + P+ +VL+KV A G+ + +R Y LP G + +G+IEA+G N + + Sbjct: 26 IRQPQGDEVLVKVVATGMCHTDLIVRDQKYPVP--LPAVLGHEGSGIIEAIGPNVTELQV 83 Query: 90 GDRVFTSSTISG------------------------------------------------ 101 GD V S G Sbjct: 84 GDHVVLSYGYCGKCTQCNTGNPAYCSEFFGRNFSGADSEGNHALCTHDQGVVNDHFFAQS 143 Query: 102 GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGV 161 +A YAL+ ++ K+ + + + +G T A I++ V S + GA G V Sbjct: 144 SFATYALSRENNTVKVTKDVPIELLGPLGCGIQTGAGACINALKVTPASSFVTWGA-GAV 202 Query: 162 GLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDI 220 GL+A A+ G I+ E ++ Q GA V N + + + IK+ G++ Sbjct: 203 GLSALLAAKVCGASIIIAVDIVESRLELAKQLGATHVINSKTQDPVAAIKEITDG-GVNF 261 Query: 221 IIEMLANVN-LSKDLSLLSHGGRVIVVGSRG---TIEINPRDTMAKESSIIGVTLFSSTK 276 +E + L + + L G++ VVG+ T + + D + +I+GV S + Sbjct: 262 ALESTGSPEILKQGVDALGILGKIAVVGAPQLGTTAQFDVNDLLLGGKTILGVVEGSGSP 321 Query: 277 EEF-QQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHG 318 ++F + Q G + Y +++ +A + G Sbjct: 322 KKFIPELVRLYQQGKFPF---DQLVKFYAFDEINQAAIDSRKG 361 >3FBG-A nrPDB Length = 346 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 83/345 (24%), Positives = 148/345 (42%), Gaps = 31/345 (8%) Query: 7 LMRAVRVFEFGGP--EVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPL 64 ++A+ + L ++ +P PK H++L+K+ + VNPV+T R S+ Sbjct: 2 SLKAIGFEQPFKLSDGNLFKTFNLDIPEPKVHEILVKIQSISVNPVDTKQRLMDVSK--- 58 Query: 65 LPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTIS--GGYAEYALAADHTVYKLPEKLD 122 P G D GV+E+VG+ + F +GD V+ S + G AEY L + V K P+ + Sbjct: 59 APRVLGFDAIGVVESVGNEVTMFNQGDIVYYSGSPDQNGSNAEYQLINERLVAKAPKNIS 118 Query: 123 FKQGAAIGIPYFTAYRALIHSACVK------AGESVLVHGASGGVGLAACQIARAYGLKI 176 +Q ++ + TAY L + G+++L+ +GGVG A QIA+AYGL++ Sbjct: 119 AEQAVSLPLTGITAYETLFDVFGISRNRNENEGKTLLIINGAGGVGSIATQIAKAYGLRV 178 Query: 177 LGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVN-LSKDLS 235 + TA E + + GA V NH+E K G + +D + + Sbjct: 179 ITTASRNETIEWTKKMGADIVLNHKESLLNQF--KTQGIELVDYVFCTFNTDMYYDDMIQ 236 Query: 236 LLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKE--------EFQQYAAALQ 287 L+ G + + + E + K S+ F + + +Y + Sbjct: 237 LVKPRGHIATIVA---FENDQDLNALKPKSLSFSHEFMFARPLNQTDDMIKHHEYLEDIT 293 Query: 288 AGMEIGWLKPVIGSQ---YPLEKVAEAHENIIHGSGATGKMILLL 329 +E +P E + +AH+ I+ + GK+++ L Sbjct: 294 NKVEQNIYQPTTTKVIEGLTTENIYQAHQ-ILESNTMIGKLVINL 337 >5TNX-A nrPDB Length = 383 Score = 197 bits (500), Expect = 7e-51, Method: Composition-based stats. Identities = 88/355 (24%), Positives = 135/355 (38%), Gaps = 65/355 (18%) Query: 30 VPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKK 89 + P+ +VL++V A G+ + +R Y LP G + AGV+EAVG N Sbjct: 37 IRAPRGDEVLVRVVATGLCHTDLIVRDQYYPVP--LPAVLGHEGAGVVEAVGPNVKTLAA 94 Query: 90 GDRVFTSSTISG------------------------------------------------ 101 GD V + G Sbjct: 95 GDHVVLTYGACGHCASCAGGHGAYCRQFFALNFGGADADGQTALRDAAGEPLHDHFFAQS 154 Query: 102 GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGV 161 +A YALA ++ K+P++ + +G T A+I+S V+ G S GA G V Sbjct: 155 SFASYALARENNAIKVPKEAPLELLGPLGCGIQTGAGAVINSLAVRTGSSFASFGA-GAV 213 Query: 162 GLAACQIARAYGLK-ILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDI 220 G++A AR G I+ + L+ GA N +EV+ +D I++ G G+D Sbjct: 214 GMSAVMAARIAGATTIIAVDIVPSRLALALELGATHAINSKEVDVVDAIREITGG-GVDY 272 Query: 221 IIEMLA-NVNLSKDLSLLSHGGRVIVVGSR---GTIEINPRDTMAKESSIIGVTLFSSTK 276 +E LS+ + L G + VVG+ E + + +I G+ S Sbjct: 273 ALESTGLPAVLSQGIDALGSRGTMGVVGAPKLGTKAEFDVNSLLLGGHTIRGIVEGDSVP 332 Query: 277 EEF--QQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 + F Q LQ L YPLE++ +A + SG T K IL L Sbjct: 333 QTFIPQLVQLHLQGRFPFDRLVKF----YPLEQINQAAAD--SSSGITLKPILRL 381 >4CPD-A nrPDB Length = 347 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 82/360 (22%), Positives = 135/360 (37%), Gaps = 53/360 (14%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPK-DHQVLIKVHACGVNPVETYIRSGTYSRKPLLP 66 MRAV V ++ P + L++VH G+ + ++ G P Sbjct: 1 MRAVVFENKERVAV----KEVNAPRLQHPLDALVRVHLAGICGSDLHLYHGKIPVLPG-- 54 Query: 67 YTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVY----------- 115 G + G +EAVG+ + GD V I+ G Y + + Sbjct: 55 SVLGHEFVGQVEAVGEGIQDLQPGDWVVGPFHIACGTCPYCRRHQYNLCERGGVYGYGPM 114 Query: 116 ----------------------KLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVL 153 KLP L ++ G TAY LI ++ G+SV Sbjct: 115 FGNLQGAQAEILRVPFSNVNLRKLPPNLSPERAIFAGDILSTAYGGLIQ-GQLRPGDSVA 173 Query: 154 VHGASGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKY 212 V GA G VGL A ++A+ G KIL E + GA N + N + +++ Sbjct: 174 VIGA-GPVGLMAIEVAQVLGASKILAIDRIPERLERAASLGA-IPINAEQENPVRRVRSE 231 Query: 213 VGEKGIDIIIEMLAN-VNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTL 271 ++G D+++E + LS L ++ GGRV VG ++ P S ++ Sbjct: 232 TNDEGPDLVLEAVGGAATLSLALEMVRPGGRVSAVG----VDNAPSFPFPLASGLVKDLT 287 Query: 272 FSSTKEEFQQYAAALQAGMEIGWLKP--VIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 F Y A+ A + G L+P ++ PLE+ +E K++L++ Sbjct: 288 FRIGLANVHLYIDAVLALLASGRLQPERIVSHYLPLEEAPRGYELFD--RKEALKVLLVV 345 >2J3K-A nrPDB Length = 345 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 77/325 (23%), Positives = 134/325 (41%), Gaps = 33/325 (10%) Query: 26 SDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPL-----LPYTPGSDVAG--VIE 78 ++ VP + VL+K + Y+R P YTPG + G V Sbjct: 30 VELRVPE-GTNSVLVKNLYLS-C--DPYMRIRMGKPDPSTAALAQAYTPGQPIQGYGVSR 85 Query: 79 AVGDNASAFKKGDRVFTSSTISGGYAEYALAAD--HTVYKLPE-KLDFKQG-AAIGIPYF 134 + +KKGD ++ + EY++ H +K+ + +G+P Sbjct: 86 IIESGHPDYKKGDLLWGIV----AWEEYSVITPMTHAHFKIQHTDVPLSYYTGLLGMPGM 141 Query: 135 TAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVL-QNG 193 TAY K GE+V V ASG VG Q+A+ G ++G+AG++E ++ + G Sbjct: 142 TAYAGFYEVCSPKEGETVYVSAASGAVGQLVGQLAKMMGCYVVGSAGSKEKVDLLKTKFG 201 Query: 194 AHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIE 253 + FN++E + + K GIDI E + L L ++ GR+ V G Sbjct: 202 FDDAFNYKEESDLTAALKRCFPNGIDIYFENVGGKMLDAVLVNMNMHGRIAVCGMISQYN 261 Query: 254 INPRDTMAKESSIIG---------VTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYP 304 + ++ + S+II V+ F +F ++ +I +++ V Sbjct: 262 LENQEGVHNLSNIIYKRNRIQGFVVSDFYDKYSKFLEFVLPHIREGKITYVEDVADG--- 318 Query: 305 LEKVAEAHENIIHGSGATGKMILLL 329 LEK EA + HG GK ++++ Sbjct: 319 LEKAPEALVGLFHGKN-VGKQVVVV 342 >1P0F-A nrPDB Length = 373 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 75/373 (20%), Positives = 133/373 (35%), Gaps = 62/373 (16%) Query: 7 LMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLP 66 +A +E P L+ I V PK H+V IK+ A G+ ++ + K P Sbjct: 9 TCKAAVAWEPHKPLSLET---ITVAPPKAHEVRIKILASGICGSDSSVLKEIIPSK--FP 63 Query: 67 YTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGG------------------------ 102 G + GV+E++G + K GD+V G Sbjct: 64 VILGHEAVGVVESIGAGVTCVKPGDKVIPLFVPQCGSCRACKSSNSNFCEKNDMGAKTGL 123 Query: 103 -----------------------YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRA 139 + EY + AD V K+ K + IG + T Y A Sbjct: 124 MADMTSRFTCRGKPIYNLMGTSTFTEYTVVADIAVAKIDPKAPL-ESCLIGCGFATGYGA 182 Query: 140 LIHSACVKAGESVLVHGASGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEVF 198 +++A V G + V G GGVG +A +A G +I+G ++ ++ GA E Sbjct: 183 AVNTAKVTPGSTCAVFGL-GGVGFSAIVGCKAAGASRIIGVGTHKDKFPKAIELGATECL 241 Query: 199 NHREVN-YIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG--GRVIVVGSRGTIE-- 253 N ++ + I ++ G+D +E + + ++ G +V+G E Sbjct: 242 NPKDYDKPIYEVICEKTNGGVDYAVECAGRIETMMNALQSTYCGSGVTVVLGLASPNERL 301 Query: 254 INPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHE 313 + S+ G EE + + ++ ++ L+++ +A E Sbjct: 302 PLDPLLLLTGRSLKGSVFGGFKGEEVSRLVDDYMKKKIN--VNFLVSTKLTLDQINKAFE 359 Query: 314 NIIHGSGATGKMI 326 + G G MI Sbjct: 360 LLSSGQGVRSIMI 372 >4OH1-A nrPDB Length = 351 Score = 193 bits (490), Expect = 9e-50, Method: Composition-based stats. Identities = 74/357 (20%), Positives = 138/357 (38%), Gaps = 41/357 (11%) Query: 2 ATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS- 60 Q + ++R FE + + + +P PKD ++ IKV + +T+I +G Sbjct: 1 GMRQLFVTSIRDFEKNTMGTVDMM-EAPMPEPKDEEIRIKVVYASICGSDTHILTGNLGE 59 Query: 61 ----RKPLLPYTPGSDVAGVIEAVGDNAS--AFKKGDRVFTSSTISG------------- 101 + +LP + G +++GVI+ VG A FK G +V + Sbjct: 60 MESTTRSMLPMSFGHELSGVIDKVGSTAEKMGFKVGQKVVANYAKYCGCCENCREGKVNL 119 Query: 102 ---------GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESV 152 G++EYA+ ++ +P+ D K A + T + A + G+SV Sbjct: 120 CSNMGYRMNGFSEYAVYHMSQIFPIPDDADLKDYALVE--PLTVALSSAEQAKISYGKSV 177 Query: 153 LVHGASGGVGLAACQIARAYGLKILGT-AGTEEGQKIVLQNGAHEVFNHREVNYIDKIKK 211 + GA GG+G+ Q+AR G + E ++ L+NGA N E ++ + Sbjct: 178 AIMGA-GGLGMMLVQLARLAGASTITVFDIVPEKLELALENGADYALNSAEEGVAERAIE 236 Query: 212 YVGEKGIDIIIEMLANVNLSK-DLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVT 270 G + D ++E +K L LL+ G + G I P + + Sbjct: 237 LAGGR-YDCVLEGTGATAAAKLGLQLLARDGDAVYFAMYGKDPILPVNLQSDLYWDQKHI 295 Query: 271 LFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 + + M+ + I ++ L +A E++ S K+++ Sbjct: 296 HGMIQGAWQFPKSIRMIPRMDFSKI---IQKEHTLTNYKQAFEDLY--SKKYAKIVI 347 >4IDE-A nrPDB Length = 332 Score = 191 bits (485), Expect = 3e-49, Method: Composition-based stats. Identities = 97/332 (29%), Positives = 152/332 (45%), Gaps = 40/332 (12%) Query: 9 RAVRVFEFGG-PEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS-RKPLLP 66 +A E+G +VLK +AVP K+ QVLIKV A +NPV+ G + LP Sbjct: 25 KAWVYSEYGKTSDVLKFDPSVAVPEIKEDQVLIKVVAASLNPVDFKRALGYFKDTDSPLP 84 Query: 67 YTPGSDVAGVIEAVGDNASAFKKGDRVFTS--------STISGGYAEYALAADHTVYKLP 118 PG DVAGV+ VG + FK GD V+ T G AEY A + + P Sbjct: 85 TIPGYDVAGVVVKVGSQVTKFKVGDEVYGDLNETALVNPTRFGSLAEYTAADERVLAHKP 144 Query: 119 EKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARA-YGLKIL 177 + L F + A++ + TA+ L A + AG+SVLV G +GGVG Q+A+ +G + Sbjct: 145 KNLSFIEAASLPLAIETAHEGL-ERAELSAGKSVLVLGGAGGVGTHIIQLAKHVFGASKV 203 Query: 178 GTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLL 237 + + ++ GA ++ + N+ D +K D++ + + K + + Sbjct: 204 AATASTKKLDLLRTLGADLAIDYTKENFEDLPEK------FDVVYDAVG--ETDKAVKAV 255 Query: 238 SHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKP 297 GG+V+ + T +K S + E+ + Y +E G +KP Sbjct: 256 KEGGKVVTIVGPATPPAILFVLTSKGSVL----------EKLKPY-------LESGKVKP 298 Query: 298 VI--GSQYPLEKVAEAHENIIHGSGATGKMIL 327 V+ S YP KV EA + S ATGK+++ Sbjct: 299 VLDPTSPYPFTKVVEAF-GYLESSRATGKVVV 329 >4EJ6-A nrPDB Length = 370 Score = 190 bits (482), Expect = 9e-49, Method: Composition-based stats. Identities = 75/346 (21%), Positives = 135/346 (39%), Gaps = 53/346 (15%) Query: 5 QKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPL 64 Q +M+AVR+ G V ++ +P P +L+KV ACG+ + ++ G + P Sbjct: 21 QSMMKAVRLESVGNISV----RNVGIPEPGPDDLLVKVEACGICGTDRHLLHGEFPSTP- 75 Query: 65 LPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTI------------------------- 99 P T G + G++ G G R+ I Sbjct: 76 -PVTLGHEFCGIVVEAGSAVRDIAPGARITGDPNISCGRCPQCQAGRVNLCRNLRAIGIH 134 Query: 100 -SGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHS---ACVKAGESVLVH 155 GG+AEY L +++P LD GA + +H + +KAG +V + Sbjct: 135 RDGGFAEYVLVPRKQAFEIPLTLDPVHGA-----FCEPLACCLHGVDLSGIKAGSTVAIL 189 Query: 156 GASGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVG 214 G G +GL Q+AR G ++ + +++ + GA + + ++ I VG Sbjct: 190 GG-GVIGLLTVQLARLAGATTVILSTRQATKRRLAEEVGATATVDPSAGDVVEAIAGPVG 248 Query: 215 --EKGIDIIIEMLA-NVNLSKDLSLLSHGGRVIVVGS---RGTIEINPRDTMAKESSIIG 268 G+D++IE + + L GG V+++G +EI P D + +E ++G Sbjct: 249 LVPGGVDVVIECAGVAETVKQSTRLAKAGGTVVILGVLPQGEKVEIEPFDILFRELRVLG 308 Query: 269 VTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHEN 314 + F AA + +I + L++ + N Sbjct: 309 SFI-----NPFVHRRAADLVATGAIEIDRMISRRISLDEAPDVISN 349 >2Y05-A nrPDB Length = 328 Score = 187 bits (474), Expect = 7e-48, Method: Composition-based stats. Identities = 67/308 (21%), Positives = 122/308 (39%), Gaps = 17/308 (5%) Query: 29 AVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFK 88 +P K+ +VL++ V+P Y+R R G VA V+E A Sbjct: 27 ELPPLKNGEVLLEALFLTVDP---YMRVAA-KRLKEGDTMMGQQVAKVVE---SKNVALP 79 Query: 89 KGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQG-AAIGIPYFTAYRALIHSACVK 147 KG V S + + + + P+ + +G+P TAY L+ VK Sbjct: 80 KGTIVLASPGWTTHSISDGKDLEKLLTEWPDTIPLSLALGTVGMPGLTAYFGLLEICGVK 139 Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYID 207 GE+V+V+ A+G VG QIA+ G K++G G++E + + G VFN++ V ++ Sbjct: 140 GGETVMVNAAAGAVGSVVGQIAKLKGCKVVGAVGSDEKVAYLQKLGFDVVFNYKTVESLE 199 Query: 208 KIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIE--------INPRDT 259 + K G D + + + + + GR+ + G+ T P Sbjct: 200 ETLKKASPDGYDCYFDNVGGEFSNTVIGQMKKFGRIAICGAISTYNRTGPLPPGPPPEIV 259 Query: 260 MAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGS 319 + +E + ++ + Q+ L + G ++ E + A ++ G Sbjct: 260 IYQELRMEAFVVYRWQGDARQKALKDLLKWVLEGKIQYKEYIIEGFENMPAAFMGMLKGD 319 Query: 320 GATGKMIL 327 GK I+ Sbjct: 320 N-LGKTIV 326 >5YLN-A nrPDB Length = 356 Score = 180 bits (457), Expect = 7e-46, Method: Composition-based stats. Identities = 72/362 (19%), Positives = 129/362 (35%), Gaps = 51/362 (14%) Query: 4 GQKLMRAVRVFEFGGPEVLKLRSDIAVPIP-KDHQVLIKVHACGVNPVETYIRSGTYSRK 62 M+A + G L D+ P+ K ++++ + + +I G Sbjct: 1 AMGSMKAYTYVKPG----LASFVDVDKPVIRKPTDAIVRIVKTTICGTDLHIIKGDVPTC 56 Query: 63 PLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFT--------------------------- 95 G + G++E VG+ S FKKGD+V Sbjct: 57 QSG-TILGHEGIGIVEEVGEGVSNFKKGDKVLISCVCACGKCYYCKKGIYAHCEDEGGWI 115 Query: 96 -SSTISGGYAEYALAAD--HTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESV 152 I G AEY +T+Y PE L + + T Y + V+ G SV Sbjct: 116 FGHLIDGMQAEYLRVPHADNTLYHTPEDLSDEALVMLSDILPTGYEIGVLKGKVEPGCSV 175 Query: 153 LVHGASGGVGLAACQIARAYG-LKILGTAGTEEGQKIVLQNGAHEVFNHRE-VNYIDKIK 210 + G SG VGLAA A+ Y K++ + + L GA N + I +I Sbjct: 176 AIIG-SGPVGLAALLTAQFYSPAKLIMVDLDDNRLETALSFGATHKVNSSDPEKAIKEIY 234 Query: 211 KYVGEKGIDIIIEMLA-NVNLSKDLSLLSHGGRVIVVGSRG-TIEINPRDTMAKESSIIG 268 +G+D+ IE + ++ G V G G +E + + ++ Sbjct: 235 DLTDGRGVDVAIEAVGIPATFDFCQKIIGVDGTVANCGVHGKPVEFDLDKLWIRNINVTT 294 Query: 269 VTLFSSTKEEFQQYAAALQAGMEIGWLKP--VIGSQYPLEKVAEAHENIIHGS-GATGKM 325 + ++T L +E ++P ++ + L ++ +A+E + K+ Sbjct: 295 GLVSTNTTP-------QLLKALESHKIEPEKLVTHYFKLSEIEKAYEVFSKAADHHAIKV 347 Query: 326 IL 327 I+ Sbjct: 348 II 349 >5KIA-A nrPDB Length = 351 Score = 179 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 77/351 (21%), Positives = 137/351 (39%), Gaps = 44/351 (12%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 67 M+A+ E G L + + P + VLIK+ + + +I + +P Sbjct: 9 MKALAKLERGPGLTL---TRVKKPEVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPV 65 Query: 68 TP--GSDVAGVIEAVGDNASAFKKGDRVFTSSTIS------------------------- 100 G + G I +G F GDRV I+ Sbjct: 66 PMHVGHEYVGEIVEMGQEVRGFSIGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNR 125 Query: 101 -GGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASG 159 G +AEY +K+P ++ A I P+ A + V GE VL+ GA G Sbjct: 126 EGAFAEYLAIPAFNAFKIPPEISDDLAA-IFDPFGNATHTALSFNLV--GEDVLITGA-G 181 Query: 160 GVGLAACQIARAYGLK-ILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGI 218 +G+ A IA+ G + ++ T + + + GA N + D + +G Sbjct: 182 PIGVMAVAIAKHVGARNVVITDINDYRLDLARRMGATRAVNVSRESLRDVMADLHMTEGF 241 Query: 219 DIIIEMLA-NVNLSKDLSLLSHGGRVIVVG-SRGTIEINPRDTMAKESSIIGVTLFSSTK 276 D+ +EM + L ++HGG+V ++G I+ + K I G+ Sbjct: 242 DVGLEMSGVPSAFTSLLESMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIY-GREMF 300 Query: 277 EEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 E + + A LQ+G++ L P+I ++ ++ + ++ G +GK+IL Sbjct: 301 ETWYKMVAMLQSGLD---LSPIITHRFAVDDYEKGFAAMLSGE--SGKVIL 346 >4UEJ-A nrPDB Length = 346 Score = 177 bits (448), Expect = 8e-45, Method: Composition-based stats. Identities = 81/361 (22%), Positives = 146/361 (40%), Gaps = 56/361 (15%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKD-HQVLIKVHACGVNPVET--YIRSGTYSRKPL 64 M++V G + ++ +P K +V +K+ + G+ + ++G + Sbjct: 1 MKSVVNDTDG----IVRVAESVIPEIKHQDEVRVKIASSGLCGSDLPRIFKNGAH----Y 52 Query: 65 LPYTPGSDVAGVIEAVGDNASAFKKGDRV--------------------------FTSST 98 P T G + +G I+AVG GD V F S Sbjct: 53 YPITLGHEFSGYIDAVGSGVDDLHPGDAVACVPLLPCFTCPECLKGFYSQCAKYDFIGSR 112 Query: 99 ISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGAS 158 GG+AEY + V+ LP + + GA I P A H A ++V++ GA Sbjct: 113 RDGGFAEYIVVKRKNVFALPTDMPIEDGAFI-EPITVGLHAF-HLAQGCENKNVIIIGA- 169 Query: 159 GGVGLAACQIARAYGLK-ILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKG 217 G +GL A Q A A G K + + E + GA + FN E++ +++ + E Sbjct: 170 GTIGLLAIQCAVALGAKSVTAIDISSEKLALAKSFGAMQTFNSSEMS-APQMQSVLRELR 228 Query: 218 ID-IIIEMLA-NVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMA-------KESSIIG 268 + +I+E + + + ++ +VG T+ + T A KE ++IG Sbjct: 229 FNQLILETAGVPQTVELAVEIAGPHAQLALVG---TLHQDLHLTSATFGKILRKELTVIG 285 Query: 269 VTLFSSTKEEFQQYAAALQAGMEIG-WLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 + S+ Q++ A + E L+P+I + E A+A +I + GK++L Sbjct: 286 SWMNYSSPWPGQEWETASRLLTERKLSLEPLIAHRGSFESFAQAVRDIAR-NAMPGKVLL 344 Query: 328 L 328 + Sbjct: 345 I 345 >4DVJ-A nrPDB Length = 363 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 83/342 (24%), Positives = 144/342 (42%), Gaps = 26/342 (7%) Query: 6 KLMRAVRVFEFGGPEVLK-----LRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS 60 + M+AV + P + L ++ P P H +L++V A VNPV+ +R T Sbjct: 21 QSMKAV---GYNKPAPITDDASLLDIELPKPAPAGHDILVEVKAVSVNPVDYKVRRSTPP 77 Query: 61 RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTI--SGGYAEYALAADHTVYKLP 118 G D AG++ AVG + + F+ GD VF + +I G AE+ L + V + P Sbjct: 78 DGTDWKVI-GYDAAGIVSAVGPDVTLFRPGDEVFYAGSIIRPGTNAEFHLVDERIVGRKP 136 Query: 119 EKLDFKQGAAIGIPYFTAYRALIHSACVK-----AGESVLVHGASGGVGLAACQIARAY- 172 + LD+ + AA+ + TA+ A V A ++L+ G +GGVG A QIAR Sbjct: 137 KTLDWAEAAALPLTSITAWEAFFDRLDVNKPVPGAAPAILIVGGAGGVGSIAVQIARQRT 196 Query: 173 GLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSK 232 L ++ TA E Q+ V GAH V +H + + +G Sbjct: 197 DLTVIATASRPETQEWVKSLGAHHVIDHSKPLAAEVAALGLGAPAFVFSTTHTDKHAAEI 256 Query: 233 DLSLLSHGGRVIVVGSRGTIEINPRD----TMAKESSIIGVTLFSSTKEEFQQYAAALQA 288 L++ GR ++ +I ++ E + E + + Sbjct: 257 A-DLIAPQGRFCLIDDPSAFDIMLFKRKAVSIHHELMFTRPMFGTPDMSEQGRLLNDVSR 315 Query: 289 GMEIGWLKPVIGSQY-PLEKVA--EAHENIIHGSGATGKMIL 327 ++ G L+ + ++ P+ +AH + G+ A GK+++ Sbjct: 316 LVDEGRLRTTLTNRLSPINAANLKQAHALVESGT-ARGKVVI 356 >4GKV-A nrPDB Length = 336 Score = 175 bits (444), Expect = 2e-44, Method: Composition-based stats. Identities = 66/352 (18%), Positives = 135/352 (38%), Gaps = 52/352 (14%) Query: 8 MRAVRVFEFGGPEVLKLRSDIA---VPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPL 64 M+A V + D+ + K + L+K+ CGV + ++++G + K Sbjct: 1 MKAAVVTK-------DHHVDVTYKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTG 53 Query: 65 LPYTPGSDVAGVIEAVGDNASAFKKGDRV---------------------------FTSS 97 G + GV+ VG ++ K GDR Sbjct: 54 --VILGHEGIGVVAEVGPGVTSLKPGDRASVAWFYEGCGHCEYCNSGNETLCRSVKNAGY 111 Query: 98 TISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGA 157 ++ GG AE + K+P+ LD ++I T Y+A+ + ++ G+ + ++G Sbjct: 112 SVDGGMAEECIVVADYAVKVPDGLDSAAASSITCAGVTTYKAV-KLSKIRPGQWIAIYGL 170 Query: 158 SGGVGLAACQIAR-AYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEK 216 G+G A Q A+ + K++ +E K+ + GA N + +++ G Sbjct: 171 G-GLGNLALQYAKNVFNAKVIAIDVNDEQLKLATEMGADLAINSHTEDAAKIVQEKTGGA 229 Query: 217 GIDIIIEMLANVNLSKDLSLLSHGGRVIVVG-SRGTIEINPRDTMAKESSIIGVTLFSST 275 ++ +A + + + GGRV+ VG ++ ++ + ++G + + Sbjct: 230 HA-AVVTAVAKAAFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTR- 287 Query: 276 KEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 Q A Q E G + P + + PL + + G G+M++ Sbjct: 288 ----QDLTEAFQFAAE-GKVVPKVALR-PLADINTIFTEMEEGK-IRGRMVI 332 >4ILK-A nrPDB Length = 359 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 77/358 (21%), Positives = 149/358 (41%), Gaps = 53/358 (14%) Query: 6 KLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLL 65 M+++ + + ++ + +P P +V +KV G+ +++I G ++ Sbjct: 19 SHMKSILIEKPNQLSII----EREIPTPSAGEVRVKVKLAGICGSDSHIYRG-HNPFAKY 73 Query: 66 PYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTI-------------------------- 99 P G + GVI+AVG+ + + G+RV + Sbjct: 74 PRVIGHEFFGVIDAVGEGVESARVGERVAVDPVVSCGHCYPCSIGKPNVCTTLAVLGVHA 133 Query: 100 SGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASG 159 GG++EYA+ +K+PE + Q A + P+ A H ++VLV+GA G Sbjct: 134 DGGFSEYAVVPAKNAWKIPEAV-ADQYAVMIEPFTIAANVTGH-GQPTENDTVLVYGA-G 190 Query: 160 GVGLAACQIAR-AYGLK-ILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKG 217 +GL Q+ + Y +K ++ +E + ++GA N+ + + + EKG Sbjct: 191 PIGLTIVQVLKGVYNVKNVIVADRIDERLEKAKESGADWAINNSQT----PLGESFAEKG 246 Query: 218 ID--IIIEMLANVNLSK-DLSLLSHGGRVIVVG-SRGTIEINPRDTMAKESSIIGVTLFS 273 I +II+ + ++ K ++L S R++++G S E+ + KE SI L + Sbjct: 247 IKPTLIIDAACHPSILKEAVTLASPAARIVLMGFSSEPSEVIQQGITGKELSIFSSRLNA 306 Query: 274 STKEEFQQYAAALQAGMEIGWLKP--VIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 + +F L G +KP +I + + VA+A K++L Sbjct: 307 N---KFPVVIDWL----SKGLIKPEKLITHTFDFQHVADAISLFELDQKHCCKVLLTF 357 >4OAQ-A nrPDB Length = 367 Score = 167 bits (424), Expect = 5e-42, Method: Composition-based stats. Identities = 69/329 (20%), Positives = 122/329 (37%), Gaps = 57/329 (17%) Query: 35 DHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVF 94 H V++K CG+ + + S + G ++ G + AVGD + FK GDRV Sbjct: 35 PHDVVLKNEVCGLCYSDIHTLSAGWQPLQRDNLVVGHEIIGEVIAVGDEVTEFKVGDRVG 94 Query: 95 TS------------------------------------STISGGYAEYALAADHTVYKLP 118 GGY+ +++A + V+ +P Sbjct: 95 IGAASSSCRSCQRCDSDNEQYCKQGAATYNSKDVRSNNYVTQGGYSSHSIADEKFVFAIP 154 Query: 119 EKLDFKQGAAIGIPYFTAYRALIHSACVKA-GESVLVHGASGGVGLAACQIARAYGLKIL 177 E L GA + T + LI + + A G++V + G G A Q A A G + Sbjct: 155 EDLPSSYGAPLMCAGITVFSPLIRNLGLDARGKNVGIIGIGGLG-HLALQFANAMGANVT 213 Query: 178 GTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANV---NLSKDL 234 + + ++ ++ GAH+ E DK + D I+ + + NLS+ L Sbjct: 214 AFSRSSSKKEQAMKLGAHDFVATGE----DKTWYKNYDDHFDFILNCASGIDGLNLSEYL 269 Query: 235 SLLSHGGRVIVVGSR---GTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGME 291 S L + + VG E++P T ++ + G +L S E + Sbjct: 270 STLKVDKKFVSVGLPPSEDKFEVSPF-TFLQQGASFGSSLLGSKTE-----VKEMLNLAA 323 Query: 292 IGWLKPVIGSQYPLEKVA--EAHENIIHG 318 ++P+I P+ + +A + G Sbjct: 324 KHNVRPMIEEV-PISEENCAKALDRCHAG 351 >1O89-A nrPDB Length = 345 Score = 165 bits (418), Expect = 2e-41, Method: Composition-based stats. Identities = 67/305 (21%), Positives = 115/305 (37%), Gaps = 18/305 (5%) Query: 35 DHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVF 94 + V + VH +N + +G P PG D AG + D F G V Sbjct: 48 EGDVTVDVHWSSLNYKDALAITGKGKIIRNFPMIPGIDFAGTVRTSED--PRFHAGQEVL 105 Query: 95 -----TSSTISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRAL--IHSACVK 147 GG AE A + +P+ LD ++ IG FTA + + A V+ Sbjct: 106 LTGWGVGENHWGGLAEQARVKGDWLVAMPQGLDARKAMIIGTAGFTAMLCVMALEDAGVR 165 Query: 148 AGE-SVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYI 206 + ++V GASGGVG A + G +++ +G E + + GA V E Sbjct: 166 PQDGEIVVTGASGGVGSTAVALLHKLGYQVVAVSGRESTHEYLKSLGASRVLPRDEFAES 225 Query: 207 DKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDT--MAKES 264 ++K V ID + + + L+K L+ +++GG V G G + + + Sbjct: 226 RPLEKQVWAGAIDTVGDKV----LAKVLAQMNYGGCVAACGLAGGFTLPTTVMPFILRNV 281 Query: 265 SIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGK 324 + GV + E Q L A + + + L + I + G+ Sbjct: 282 RLQGVDSVMTPPERRAQAWQRLVADLPESFYTQA-AKEISLSEAPN-FAEAIINNQIQGR 339 Query: 325 MILLL 329 ++ + Sbjct: 340 TLVKV 344 >3WLE-A nrPDB Length = 341 Score = 162 bits (411), Expect = 1e-40, Method: Composition-based stats. Identities = 72/345 (20%), Positives = 131/345 (37%), Gaps = 51/345 (14%) Query: 14 FEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDV 73 F F LKLR+D+ V PK Q+L+KV A G+ + ++ Y G ++ Sbjct: 15 FVFNKQSGLKLRNDLPVHKPKAGQLLLKVDAVGLCHSDLHVIYEGLDCGDN--YVMGHEI 72 Query: 74 AGVIEAVGDNASAFKKGDRV----------------------------FTSSTISGGYAE 105 AG + AVGD+ +K GDRV + GGY + Sbjct: 73 AGTVAAVGDDVINYKVGDRVACVGPNGCGGCKYCRGAIDNVCKNAFGDWFGLGYDGGYQQ 132 Query: 106 YALA-ADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLA 164 Y L + ++P+ + AA T Y A+ A V ++L+ GA G Sbjct: 133 YLLVTRPRNLSRIPDNVSADVAAASTDAVLTPYHAIKM-AQVSPTSNILLIGAGGLG-GN 190 Query: 165 ACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEM 224 A Q+A+A+G K+ +E + + GA V+ + + + + + Sbjct: 191 AIQVAKAFGAKVTVLDKKKEARDQAKKLGADAVY--------ETLPESISPGSFSACFDF 242 Query: 225 LA-NVNLSKDLSLLSHGGRVIVVGSRGT-IEINPRDTMAKESSIIGVTLFSSTKEEFQQY 282 ++ + G ++ VG + N D +E I+G ++ Sbjct: 243 VSVQATFDVCQKYVEPKGVIMPVGLGAPNLSFNLGDLALREIRILGSFWGTTND------ 296 Query: 283 AAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 + + G +KPV+ L+++ E E + + G+++ Sbjct: 297 LDDVLKLVSEGKVKPVV-RSAKLKELPEYIEK-LRNNAYEGRVVF 339 >6FG0-A nrPDB Length = 352 Score = 157 bits (398), Expect = 5e-39, Method: Composition-based stats. Identities = 67/355 (18%), Positives = 122/355 (34%), Gaps = 45/355 (12%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPL-LP 66 M+AV+ E G V+ DI P P ++L+KV A G+ + + ++ LP Sbjct: 1 MKAVQYTEIGSEPVV---VDIPTPTPGPGEILLKVTAAGLCHSDITVMDMPAAQYAGGLP 57 Query: 67 YTPGSDVAGVIEAVGDNASAFKKGDRVF-------------------------------T 95 T G + G + +G+ + F GD V Sbjct: 58 LTLGHEGVGTVAELGEGVTGFGVGDAVAVYGPWGCGACHACARGRENYCTRAADLGITPP 117 Query: 96 SSTISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVH 155 G AEY + LD A + T Y A+ + S V Sbjct: 118 GYGSPGSMAEYMIVDSARHLVPIGDLDPVAAAPLTDAGLTPYHAISRVLPLLGPGSTAVV 177 Query: 156 GASGGVGLAACQIARAYG-LKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVG 214 GG+G QI RA +++ ++ + + GA D I++ G Sbjct: 178 IGVGGLGHVGIQILRAVSAARVIAVDLDDDRLALAREVGADAAVKSGA-GAADAIRELTG 236 Query: 215 EKGIDIIIEMLA-NVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFS 273 +G + + + + +++ G + VVG M + + VT + Sbjct: 237 GQGATAVFDFVGAQSTIDTAQQVVAVDGHISVVGIHAGAHAKVGFWMIPFGASV-VTPYW 295 Query: 274 STKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILL 328 T+ E + A +AG + + L++ A+ + GS G+ +++ Sbjct: 296 GTRSELMEVVALARAGRL-----DIHTETFTLDEGPAAYRRLREGS-IRGRGVVV 344 >5LB9-A nrPDB Length = 385 Score = 157 bits (396), Expect = 9e-39, Method: Composition-based stats. Identities = 73/361 (20%), Positives = 123/361 (34%), Gaps = 46/361 (12%) Query: 7 LMRAVRVFEFGGPEVLKLRSDIAVPI--PKDHQVLIKVHACGVNPVETYIRSGTYSRKP- 63 +AV + G P+ + + ++V++K VNP + G Y KP Sbjct: 24 TAQAVLYTQHGEPKDVLFTQSFEIDDDNLAPNEVIVKTLGSPVNPSDINQIQGVYPSKPA 83 Query: 64 -------LLPYTP-GSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVY 115 P P G++ + VG N S+ + GD V S G + +AL D Sbjct: 84 KTTGFGTTEPAAPCGNEGLFEVIKVGSNVSSLEAGDWVIPSHVNFGTWRTHALGNDDDFI 143 Query: 116 KL-----------PEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLV-HGASGGVGL 163 KL P L QGA I + AY L H + G+ + +G + VG Sbjct: 144 KLPNPAQSKANGKPNGLTINQGATISVNPLVAYLMLTHYVKLTPGKDWFIQNGGTSAVGK 203 Query: 164 AACQIARAYGLKILGTAGT----EEGQKIVLQNGAHEVF-----NHREVNY-IDKIKKYV 213 A QI + + +E + + GA +V N RE I + K Sbjct: 204 YASQIGKLLNFNSISVIRDRPNLDEVVASLKELGATQVITEDQNNSREFGPTIKEWIKQS 263 Query: 214 GEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRG--TIEINPRDTMAKESSIIGVT- 270 G + + + + + + L++ G ++ G + I + K + G Sbjct: 264 GGEA-KLALNCVGGKSSTGIARKLNNNGLMLTYGGMSFQPVTIPTSLYIFKNFTSAGFWV 322 Query: 271 --LFSSTKEEFQQYAAALQAGMEIGW------LKPVIGSQYPLEK-VAEAHENIIHGSGA 321 L + KE + A E G ++ + PL + + N G Sbjct: 323 TELLKNNKELKTSTLNQIIAWYEEGKLTDAKSIETLYDGTKPLHELYQDGVANSKDGKQL 382 Query: 322 T 322 Sbjct: 383 I 383 >3IP1-A nrPDB Length = 404 Score = 155 bits (392), Expect = 2e-38, Method: Composition-based stats. Identities = 61/343 (17%), Positives = 125/343 (36%), Gaps = 61/343 (17%) Query: 29 AVPIP---KDHQVLIKVHACGVNPVETYIRSGT------YSRKPLLPYTPGSDVAGVIEA 79 VP P K +++IKV ACG+ + ++ Y P T G + +GV+ Sbjct: 46 EVPEPRIEKPTEIIIKVKACGICGSDVHMAQTDEEGYILYPGLTGFPVTLGHEFSGVVVE 105 Query: 80 VGDN------ASAFKKGDRVFT--------------------------SSTISGGYAEYA 107 G F+ G+ V + G +AEY Sbjct: 106 AGPEAINRRTNKRFEIGEPVCAEEMLWCGHCRPCAEGFPNHCENLNELGFNVDGAFAEYV 165 Query: 108 LAADHTVYKLPEKLDFKQ------GAAIGIPYFTAYRAL-IHSACVKAGESVLVHGASGG 160 + L E + ++ P AY A+ + ++ G++V++ G G Sbjct: 166 KVDAKYAWSLRELEGVYEGDRLFLAGSLVEPTSVAYNAVIVRGGGIRPGDNVVILGG-GP 224 Query: 161 VGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGID 219 +GLAA I + G K++ + +E + + + GA V + + N+++ + Y G Sbjct: 225 IGLAAVAILKHAGASKVILSEPSEVRRNLAKELGADHVIDPTKENFVEAVLDYTNGLGAK 284 Query: 220 IIIEMLANVN--LSKDLSLLSHG----GRVIVVG-SRGTIEINPRDTMAKESSIIGVTLF 272 + +E + ++ V +V + I + + + I+G Sbjct: 285 LFLEATGVPQLVWPQIEEVIWRARGINATVAIVARADAKIPLTGEVFQVRRAQIVGSQGH 344 Query: 273 SSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENI 315 S F + + + +GM++ + I +E++ E + + Sbjct: 345 SGHG-TFPRVISLMASGMDMTKI---ISKTVSMEEIPEYIKRL 383 >3B70-A nrPDB Length = 371 Score = 151 bits (382), Expect = 4e-37, Method: Composition-based stats. Identities = 73/346 (21%), Positives = 131/346 (37%), Gaps = 42/346 (12%) Query: 20 EVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEA 79 + + + + P+ QV ++V A +NP +T +R G ++ G+D AG + A Sbjct: 21 DEVTVWNAAPCPMLPRDQVYVRVEAVAINPSDTKMR-GQFATPWAF---LGTDYAGTVVA 76 Query: 80 VGDNASAFKKGDRVFTSST-------ISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIP 132 VG + + + GDRV+ + G +++Y + K+P+ L F+Q AA+ Sbjct: 77 VGSDVTHIQVGDRVYGAQNEMCPRTPDQGAFSQYTVTRGRVWAKIPKGLSFEQAAALPAG 136 Query: 133 YFTAYRALIHSACVKAGES------------VLVHGASGGVGLAACQIARAYGLKILGTA 180 TA A+ S VLV+G S Q+ R G + T Sbjct: 137 ISTAGLAMKLLGLPLPSPSADQPPTHSKPVYVLVYGGSTATATVTMQMLRLSGYIPIATC 196 Query: 181 GTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLL--S 238 + + GA EVF++R N I+ Y + + ++ + NV + Sbjct: 197 -SPHNFDLAKSRGAEEVFDYRAPNLAQTIRTYT-KNNLRYALDCITNVESTTFCFAAIGR 254 Query: 239 HGGRVIVVGS---------RGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQA- 288 GG + + T + T+ E S EE +Q+ L Sbjct: 255 AGGHYVSLNPFPEHAATRKMVTTDWTLGPTIFGEGSTWPAPYGRPGSEEERQFGEDLWRI 314 Query: 289 ---GMEIGWL--KPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL 329 +E G L P+ Q + + + E + G + K+++ L Sbjct: 315 AGQLVEDGRLVHHPLRVVQGGFDHIKQGMELVRKGELSGEKLVVRL 360 >1YKF-A nrPDB Length = 352 Score = 147 bits (371), Expect = 7e-36, Method: Composition-based stats. Identities = 56/342 (16%), Positives = 111/342 (32%), Gaps = 41/342 (11%) Query: 25 RSDIAVPIPKDHQVLIKVHACGVNPVETY-IRSGTYSRKPLLPYTPGSDVAGVIEAVGDN 83 + P P +++ A + + + G + G + G + VG Sbjct: 14 WIEKEKPAPGPFDAIVRPLAVAPCTSDIHTVFEGAIGERHN--MILGHEAVGEVVEVGSE 71 Query: 84 ASAFKKGDRVFT-----------------------------SSTISGGYAEYALAADH-- 112 FK GDRV S+ G + E+ D Sbjct: 72 VKDFKPGDRVVVPAITPDWRTSEVQRGYHQHSGGMLAGWKFSNVKDGVFGEFFHVNDADM 131 Query: 113 TVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAY 172 + LP+++ + I T + A ++ G +V V G G VGL A A+ Sbjct: 132 NLAHLPKEIPLEAAVMIPDMMTTGFHGA-ELADIELGATVAVLGI-GPVGLMAVAGAKLR 189 Query: 173 GL-KILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLS 231 G +I+ GA ++ N+++ +I KG+D I N ++ Sbjct: 190 GAGRIIAVGSRPVCVDAAKYYGATDIVNYKDGPIESQIMNLTEGKGVDAAIIAGGNADIM 249 Query: 232 K-DLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGM 290 + ++ GG + V G E+ P + + T+ + L + Sbjct: 250 ATAVKIVKPGGTIANVNYFGEGEVLPVPRLEWGCGMAHKTIKGGLCPGGRLRMERLIDLV 309 Query: 291 EIGWLKP--VIGSQY-PLEKVAEAHENIIHGSGATGKMILLL 329 + P ++ + + + +A + K +++L Sbjct: 310 FYKRVDPSKLVTHVFRGFDNIEKAFMLMKDKPKDLIKPVVIL 351 >1UUF-A nrPDB Length = 369 Score = 147 bits (370), Expect = 9e-36, Method: Composition-based stats. Identities = 69/352 (19%), Positives = 125/352 (35%), Gaps = 63/352 (17%) Query: 9 RAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYT 68 +AV + P DI P + V I++ CGV + + ++ + P Sbjct: 24 KAVGAYSAKQPLE---PMDITRREPGPNDVKIEIAYCGVCHSDLHQVRSEWAGT-VYPCV 79 Query: 69 PGSDVAGVIEAVGDNASAFKKGDRVFTSSTIS---------------------------- 100 PG ++ G + AVGD + GD V + Sbjct: 80 PGHEIVGRVVAVGDQVEKYAPGDLVGVGCIVDSCKHCEECEDGLENYCDHMTGTYNSPTP 139 Query: 101 -------GGYAEYALAADHTVYKL--PEKLDFKQGAAIGIPYFTAYRALIH-SACVKAGE 150 GGY++ + + V ++ P++ A + T Y L H A Sbjct: 140 DEPGHTLGGYSQQIVVHERYVLRIRHPQE-QLAAVAPLLCAGITTYSPLRHWQAGPGKKV 198 Query: 151 SVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIK 210 V+ G G ++A A G ++ +E ++ GA EV N R + + Sbjct: 199 GVVGIGGL---GHMGIKLAHAMGAHVVAFTTSEAKREAAKALGADEVVNSRNADEMAAHL 255 Query: 211 KYVGEKGIDIIIEMLANV-NLSKDLSLLSHGGRVIVVGSRGTIEINP--RDTMAKESSII 267 K D I+ +A NL +LL G + +VG+ T +P + + K +I Sbjct: 256 KS-----FDFILNTVAAPHNLDDFTTLLKRDGTMTLVGAPATPHKSPEVFNLIMKRRAIA 310 Query: 268 GVTLFSST-KEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHG 318 G + +E + A +I ++ +++ EA+E ++ G Sbjct: 311 GSMIGGIPETQEMLDFCAEHGIVADIEMIRA--------DQINEAYERMLRG 354 >3FSR-A nrPDB Length = 352 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 57/342 (16%), Positives = 117/342 (34%), Gaps = 41/342 (11%) Query: 25 RSDIAVPIPKDHQVLIKVHACGVNPVETY-IRSGTYSRKPLLPYTPGSDVAGVIEAVGDN 83 + P P +++ A + + + G + G + G + VG Sbjct: 14 WIEKEKPAPGPFDAIVRPLAVAPCTSDIHTVFEGAIGERHN--MILGHEAVGEVVEVGSE 71 Query: 84 ASAFKKGDRVFT-----------------------------SSTISGGYAEYALAADH-- 112 FK GDRV S+ G + E+ D Sbjct: 72 VKDFKPGDRVVVPAITPDWRTSEVQRGYHQHSGGMLAGWKFSNVKDGVFGEFFHVNDADM 131 Query: 113 TVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAY 172 + LP+++ + I T + A ++ G SV+V G G VGL A+ Sbjct: 132 NLAHLPKEIPLEAAVMIPDMMTTGFHGA-ELADIQMGSSVVVIGI-GAVGLMGIAGAKLR 189 Query: 173 GL-KILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLAN-VNL 230 G +I+G + GA ++ N++ + +D++ K KG+D +I L Sbjct: 190 GAGRIIGVGSRPICVEAAKFYGATDILNYKNGHIVDQVMKLTNGKGVDRVIMAGGGSETL 249 Query: 231 SKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGM 290 S+ +S++ GG + + G+ + + + T+ + L + Sbjct: 250 SQAVSMVKPGGIISNINYHGSGDALLIPRVEWGCGMAHKTIKGGLCPGGRLRMERLIDLV 309 Query: 291 EIGWLKP--VIGSQY-PLEKVAEAHENIIHGSGATGKMILLL 329 + P ++ + + + +A + K +++L Sbjct: 310 FYKRVDPSKLVTHVFRGFDNIEKAFMLMKDKPKDLIKPVVIL 351 >3FPC-A nrPDB Length = 352 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 54/342 (15%), Positives = 114/342 (33%), Gaps = 41/342 (11%) Query: 25 RSDIAVPIPKDHQVLIKVHACGVNPVETY-IRSGTYSRKPLLPYTPGSDVAGVIEAVGDN 83 + P P +++ A + + + G + G + G + VG Sbjct: 14 WIEKEKPAPGPFDAIVRPLAVAPCTSDIHTVFEGAIGERHN--MILGHEAVGEVVEVGSE 71 Query: 84 ASAFKKGDRVFT-----------------------------SSTISGGYAEYALAADH-- 112 FK GDRV S+ G + E+ D Sbjct: 72 VKDFKPGDRVVVPAITPDWRTSEVQRGYHQHSGGMLAGWKFSNVKDGVFGEFFHVNDADM 131 Query: 113 TVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAY 172 + LP+++ + I T + A +K G++V V G G VGL + A Sbjct: 132 NLAHLPKEIPLEAAVMIPDMMTTGFHGA-ELANIKLGDTVCVIGI-GPVGLMSVAGANHL 189 Query: 173 GL-KILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANV-NL 230 G +I + I L+ GA ++ N++ + +++I K KG+D ++ +V Sbjct: 190 GAGRIFAVGSRKHCCDIALEYGATDIINYKNGDIVEQILKATDGKGVDKVVIAGGDVHTF 249 Query: 231 SKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGM 290 ++ + ++ G + V G + + + + L + Sbjct: 250 AQAVKMIKPGSDIGNVNYLGEGDNIDIPRSEWGVGMGHKHIHGGLCPGGRLRMERLIDLV 309 Query: 291 EIGWLKP--VIGSQY-PLEKVAEAHENIIHGSGATGKMILLL 329 + P ++ + + + +A + K +++L Sbjct: 310 FYKRVDPSKLVTHVFRGFDNIEKAFMLMKDKPKDLIKPVVIL 351 >3FPL-A nrPDB Length = 351 Score = 144 bits (364), Expect = 4e-35, Method: Composition-based stats. Identities = 58/342 (16%), Positives = 111/342 (32%), Gaps = 41/342 (11%) Query: 25 RSDIAVPIPKDHQVLIKVHACGVNPVETY-IRSGTYSRKPLLPYTPGSDVAGVIEAVGDN 83 + P+ + +++ A + + + G + G + G + VG Sbjct: 14 WIEKERPVAGSYDAIVRPLAVSPCTSDIHTVFEGALGDRKN--MILGHEAVGEVVEVGSE 71 Query: 84 ASAFKKGDRVFTSSTI-----------------------------SGGYAEYALAADH-- 112 FK GDRV T G + EY D Sbjct: 72 VKDFKPGDRVIVPCTTPDWRSLEVQAGFQQHSNGMLAGWKFSNFKDGVFGEYFHVNDADM 131 Query: 113 TVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAY 172 + LP+ + + I T + A ++ G +V V G G VGL A A+ Sbjct: 132 NLAILPKDMPLENAVMITDMMTTGFHGA-ELADIELGATVAVLGI-GPVGLMAVAGAKLR 189 Query: 173 GL-KILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLS 231 G +I+ GA ++ N+++ +I KG+D I N ++ Sbjct: 190 GAGRIIAVGSRPVCVDAAKYYGATDIVNYKDGPIESQIMNLTEGKGVDAAIIAGGNADIM 249 Query: 232 K-DLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGM 290 + ++ GG + V G E+ P + + T+ + A L+ + Sbjct: 250 ATAVKIVKPGGTIANVNYFGEGEVLPVPRLEWGCGMAHKTIKGGLCPGGRLRAEMLRDMV 309 Query: 291 EIGWLK--PVIGSQY-PLEKVAEAHENIIHGSGATGKMILLL 329 + ++ Y + + EA + K +++L Sbjct: 310 VYNRVDLSKLVTHVYHGFDHIEEALLLMKDKPKDLIKAVVIL 351 >1KEV-A nrPDB Length = 351 Score = 144 bits (363), Expect = 6e-35, Method: Composition-based stats. Identities = 59/342 (17%), Positives = 117/342 (34%), Gaps = 41/342 (11%) Query: 25 RSDIAVPIPKDHQVLIKVHACGVNPVETY-IRSGTYSRKPLLPYTPGSDVAGVIEAVGDN 83 + P+ + +++ A + + + G + G + G + VG Sbjct: 14 WIEKERPVAGSYDAIVRPLAVSPCTSDIHTVFEGALGDRKN--MILGHEAVGEVVEVGSE 71 Query: 84 ASAFKKGDRVFTSSTI-----------------------------SGGYAEYALAADH-- 112 FK GDRV T G + EY D Sbjct: 72 VKDFKPGDRVIVPCTTPDWRSLEVQAGFQQHSNGMLAGWKFSNFKDGVFGEYFHVNDADM 131 Query: 113 TVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAY 172 + LP+ + + I T + A ++ G SV+V G G VGL A+ Sbjct: 132 NLAILPKDMPLENAVMITDMMTTGFHGA-ELADIQMGSSVVVIGI-GAVGLMGIAGAKLR 189 Query: 173 GL-KILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLAN-VNL 230 G +I+G + GA ++ N++ + +D++ K KG+D +I L Sbjct: 190 GAGRIIGVGSRPICVEAAKFYGATDILNYKNGHIVDQVMKLTNGKGVDRVIMAGGGSETL 249 Query: 231 SKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGM 290 S+ +S++ GG + + G+ + + + T+ + A L+ + Sbjct: 250 SQAVSMVKPGGIISNINYHGSGDALLIPRVEWGCGMAHKTIKGGLCPGGRLRAEMLRDMV 309 Query: 291 EIGWLK--PVIGSQY-PLEKVAEAHENIIHGSGATGKMILLL 329 + ++ Y + + EA + K +++L Sbjct: 310 VYNRVDLSKLVTHVYHGFDHIEEALLLMKDKPKDLIKAVVIL 351 >1YQX-A nrPDB Length = 366 Score = 141 bits (356), Expect = 4e-34, Method: Composition-based stats. Identities = 50/277 (18%), Positives = 98/277 (35%), Gaps = 44/277 (15%) Query: 34 KDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRV 93 + V KV CGV + + + + P PG ++ G + VG GD+V Sbjct: 40 GEEDVRFKVLYCGVCHSDLHSIKNDWG-FSMYPLVPGHEIVGEVTEVGSKVKKVNVGDKV 98 Query: 94 FTSSTIS----------------------------------GGYAEYALAADHTVYKLPE 119 + GGY+ + +A + + + P+ Sbjct: 99 GVGCLVGACHSCESCANDLENYCPKMILTYASIYHDGTITYGGYSNHMVANERYIIRFPD 158 Query: 120 KLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGT 179 + GA + T Y L + + G+ + + G G A + A+A+G K+ Sbjct: 159 NMPLDGGAPLLCAGITVYSPLKYFGLDEPGKHIGIVGLGGLG-HVAVKFAKAFGSKVTVI 217 Query: 180 AGTEEGQKIVLQ-NGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANV-NLSKDLSLL 237 + + ++ L+ GA R+ + + II+ ++ V L LL Sbjct: 218 STSPSKKEEALKNFGADSFLVSRDQEQMQAAAGTLDG-----IIDTVSAVHPLLPLFGLL 272 Query: 238 SHGGRVIVVGSRG-TIEINPRDTMAKESSIIGVTLFS 273 G++I+VG+ +E+ +A + G + Sbjct: 273 KSHGKLILVGAPEKPLELPAFSLIAGRKIVAGSGIGG 309 >3TWO-A nrPDB Length = 348 Score = 141 bits (355), Expect = 5e-34, Method: Composition-based stats. Identities = 57/325 (17%), Positives = 111/325 (34%), Gaps = 53/325 (16%) Query: 34 KDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRV 93 VLI + G+ + + + + + P PG ++AG+I+ VG FK GD V Sbjct: 28 GPRDVLIDILYAGICHSDIHSAYSEWK-EGIYPMIPGHEIAGIIKEVGKGVKKFKIGDVV 86 Query: 94 FTSSTIS------------------------------------GGYAEYALAADHTVYKL 117 ++ GGY+ + ++ V + Sbjct: 87 GVGCFVNSCKACKPCKEHQEQFCTKVVFTYDCLDSFHDNEPHMGGYSNNIVVDENYVISV 146 Query: 118 PEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKIL 177 + ++ A + T Y L + V G V V GG+G A + A A G ++ Sbjct: 147 DKNAPLEKVAPLLCAGITTYSPL-KFSKVTKGTKVGV-AGFGGLGSMAVKYAVAMGAEVS 204 Query: 178 GTAGTEEGQKIVLQNGAHEVF-NHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSL 236 A E ++ L G + + ++ D L L L Sbjct: 205 VFARNEHKKQDALSMGVKHFYTDPKQCKEELDFIISTIPTHYD----------LKDYLKL 254 Query: 237 LSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLK 296 L++ G + +VG +E+ P ++ + ++ S ++ + ++ + Sbjct: 255 LTYNGDLALVGLP-PVEVAPVLSVFDFIHLGNRKVYGSLIGGIKETQEMVDFSIK-HNIY 312 Query: 297 PVIGSQYPLEKVAEAHENIIHGSGA 321 P I + + A+ N+ HG Sbjct: 313 PEIDLILG-KDIDTAYHNLTHGKAK 336 >5H82-A nrPDB Length = 389 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 60/338 (17%), Positives = 113/338 (33%), Gaps = 64/338 (18%) Query: 34 KDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRV 93 +H V KV CG+ + TY P+ PG ++ G++ +G+ FK GD+V Sbjct: 52 GEHDVQFKVLYCGLCDWDVITTKNTYGTTK-YPFVPGHEIMGIVTEIGNKVKKFKVGDKV 110 Query: 94 FTSSTIS-----------------------------------------------GGYAEY 106 + I GGY+ Sbjct: 111 GVGNFIGSCGKCERCNEGLEPYCPKVIYTDGTAFSDENNTVYGDVSGDGEDRIYGGYSNI 170 Query: 107 ALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAAC 166 +A ++ V++ PE L G I Y + H K G S+ V G G +G A Sbjct: 171 MVANEYVVFRWPENLPLAAGVPILCGGIVPYSPMRHFGLDKPGLSIGVVGF-GRIGKLAV 229 Query: 167 QIARAYGLKILGTAGT-EEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEML 225 + A+A+G + + + + Q+ + + G +E + + + I + + Sbjct: 230 KFAKAFGANVTVISTSISKKQEAIEKYGVDRFLISKEPEEMKAAESTLDG-----IFDCV 284 Query: 226 ANVNLSKDLSLLSH-GGRVIVVGSR-GTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYA 283 +V+ L L G +++G E+ + +G ++ Sbjct: 285 PSVHPLHPLLNLLKFEGTFVMLGVAVEAYELPVSPLLMGRRKFVGSISG-----TMKETQ 339 Query: 284 AALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGA 321 L + + + P++ V A E I G+ Sbjct: 340 EMLDFAAKHNIVSDI--ELIPMDYVNTALERIAKGNHK 375 >5GXF-A nrPDB Length = 330 Score = 138 bits (349), Expect = 2e-33, Method: Composition-based stats. Identities = 66/302 (21%), Positives = 120/302 (39%), Gaps = 16/302 (5%) Query: 36 HQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVF- 94 +V + V VN + P+ PG D AG +E D +K GD+V Sbjct: 31 GEVTVAVEYSTVNYKDGLCIGPGGGLVRKYPHVPGIDFAGTVENSSDE--RYKPGDKVVL 88 Query: 95 ----TSSTISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALI--HSACVKA 148 GGY++ A + LPE LD +Q A+G FTA A++ + Sbjct: 89 TGWRVGEAHWGGYSQKANVRADWLVPLPEGLDTRQAMAVGTAGFTAMLAVMALEDHGLTP 148 Query: 149 GE-SVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYID 207 G VLV GA+GGVG A I G ++ G E + GA ++ E+N + Sbjct: 149 GHGPVLVTGAAGGVGSVATAILAHLGYEVAAVTGRPETADYLTSLGATQIVARDEIN--E 206 Query: 208 KIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDT--MAKESS 265 +K+ + + ++ + L++ L + +G V VG G + + + + Sbjct: 207 TVKRPLESEIWAGCVDAVGGAMLARVLGQMKYGASVAAVGLAGGAGLPATVIPFLLRGVN 266 Query: 266 IIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKM 325 ++G+ + + + + L+ +I L + +I+ G G++ Sbjct: 267 LLGIDSVMQPYANRLRAWERIARDLPMDKLEAMI-RPATLSDLPGLGADILKGQ-VQGRV 324 Query: 326 IL 327 ++ Sbjct: 325 VV 326 >3M6I-A nrPDB Length = 363 Score = 137 bits (346), Expect = 6e-33, Method: Composition-based stats. Identities = 60/333 (18%), Positives = 114/333 (34%), Gaps = 51/333 (15%) Query: 32 IPKDHQVLIKVHACGVNPVETYIRSGT--YSRKPLLPYTPGSDVAGVIEAVGDNASAFKK 89 K+ +V + V + G+ + + + G + AG + AV + + K Sbjct: 37 ELKEGEVTVAVRSTGICGSDVHFWKHGCIGPMIVECDHVLGHESAGEVIAVHPSVKSIKV 96 Query: 90 GDRV---------------------------FTSSTISGGYAEYALAADHTVYKLPEKLD 122 GDRV ++ + G Y +K+ + Sbjct: 97 GDRVAIEPQVICNACEPCLTGRYNGCERVDFLSTPPVPGLLRRYVNHPAVWCHKI-GNMS 155 Query: 123 FKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGT 182 ++ GA + + A + A V+ G+ VL+ GA G +GL A+A G L Sbjct: 156 YENGAMLE--PLSVALAGLQRAGVRLGDPVLICGA-GPIGLITMLCAKAAGACPLVITDI 212 Query: 183 EE-GQKIVLQNGAHEVFNHR-----EVNYIDKIKKYVGEKGIDIIIEMLA-NVNLSKDLS 235 +E K + EV H+ KI + G + +E +++ + Sbjct: 213 DEGRLKFAKEI-CPEVVTHKVERLSAEESAKKIVESFGGIEPAVALECTGVESSIAAAIW 271 Query: 236 LLSHGGRVIVVGSR-GTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGW 294 + GG+V V+G I+I +E + + +T +E G Sbjct: 272 AVKFGGKVFVIGVGKNEIQIPFMRASVREVDLQFQYRYCNTWP-------RAIRLVENGL 324 Query: 295 LK--PVIGSQYPLEKVAEAHENIIHGSGATGKM 325 + ++ ++PLE +A E K+ Sbjct: 325 VDLTRLVTHRFPLEDALKAFETASDPKTGAIKV 357 >2OUI-A nrPDB Length = 360 Score = 133 bits (336), Expect = 7e-32, Method: Composition-based stats. Identities = 62/359 (17%), Positives = 125/359 (34%), Gaps = 45/359 (12%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETY-IRSGTYSRKPLLP 66 M+ + + G + +P L++ A +T+ + +G + Sbjct: 1 MKGLAMLGIGRIG----WIEKKIPECGPLDALVRPLALAPCTSDTHTVWAGAIGDRHD-- 54 Query: 67 YTPGSDVAGVIEAVGDNASAFKKGDRVFT-----------------------------SS 97 G + G I VG K GD+V S+ Sbjct: 55 MILGHEAVGQIVKVGSLVKRLKVGDKVIVPAITPDWGEEESQRGYPMHSGGMLGGWKFSN 114 Query: 98 TISGGYAE--YALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVH 155 G ++E + AD + LP + + + T + A +K G++V V Sbjct: 115 FKDGVFSEVFHVNEADANLALLPRDIKPEDAVMLSDMVTTGFHGA-ELANIKLGDTVCVI 173 Query: 156 GASGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVG 214 G G VGL + A G +I + I L+ GA ++ N++ + +++I K Sbjct: 174 GI-GPVGLMSVAGANHLGAGRIFAVGSRKHCCDIALEYGATDIINYKNGDIVEQILKATD 232 Query: 215 EKGIDIIIEMLANV-NLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFS 273 KG+D ++ +V ++ + ++ G + V G + P + + Sbjct: 233 GKGVDKVVIAGGDVHTFAQAVKMIKPGSDIGNVNYLGEGDNIPIPRSEWGVGMGHKHIHG 292 Query: 274 STKEEFQQYAAALQAGMEIGWLKP--VIGSQY-PLEKVAEAHENIIHGSGATGKMILLL 329 + L + + G L +I ++ LEKV +A + + K ++ + Sbjct: 293 GLTPGGRVRMEKLASLISTGKLDTSKLITHRFEGLEKVEDALMLMKNKPADLIKPVVRI 351 >5FI5-A nrPDB Length = 357 Score = 133 bits (336), Expect = 7e-32, Method: Composition-based stats. Identities = 52/269 (19%), Positives = 98/269 (36%), Gaps = 36/269 (13%) Query: 34 KDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRV 93 +H V +KV CG + + + PY G ++ G + VG FK GD+V Sbjct: 41 GEHDVQLKVLYCGTCQYDREMSKNKFGFT-SYPYVLGHEIVGEVTEVGSKVQKFKVGDKV 99 Query: 94 FTSS--------------------------TISGGYAEYALAADHTVYKLPEKLDFKQGA 127 +S + G + A+ ++ V + PE L G Sbjct: 100 GVASIIETCGKCEMCTNEVENYCPEAGSIDSNYGACSNIAVINENFVIRWPENLPLDSGV 159 Query: 128 AIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGT-EEGQ 186 + TAY + K G+ + + G G A + A+A+G K+ + + ++ + Sbjct: 160 PLLCAGITAYSPMKRYGLDKPGKRIGIAGLGGLG-HVALRFAKAFGAKVTVISSSLKKKR 218 Query: 187 KIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEML-ANVNLSKDLSLLSHGGRVIV 245 + + GA + + II+ + N +L L+LL G++I+ Sbjct: 219 EAFEKFGADSFLVSSNPEEMQGAAGTLDG-----IIDTIPGNHSLEPLLALLKPLGKLII 273 Query: 246 VGSRG-TIEINPRDTMAKESSIIGVTLFS 273 +G+ E+ + + T S Sbjct: 274 LGAPEMPFEVPAPSLLMGGKVMAASTAGS 302 >5Z0C-A nrPDB Length = 374 Score = 133 bits (335), Expect = 9e-32, Method: Composition-based stats. Identities = 57/322 (17%), Positives = 113/322 (35%), Gaps = 51/322 (15%) Query: 34 KDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRV 93 + V KV CG+ + + +S + P PG ++ G + VG + FK GD+V Sbjct: 37 GELDVTFKVLYCGICHSDLHYIKNEWSNT-IYPALPGHEIVGEVTEVGSKVNKFKVGDKV 95 Query: 94 FTSSTIS----------------------------------GGYAEYALAADHTVYKLPE 119 + GGY++ + +H ++P+ Sbjct: 96 GVGCIVGSCHSCPNCNNHLENYCPNRILTFGSRYYDGTLNHGGYSDLMVVQEHFAVRIPD 155 Query: 120 KLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGT 179 L A + T Y L + K G V V G G A + A+A+G+K+ Sbjct: 156 ALPLDSAAPLLCAGITVYSPLRYYGLDKPGLHVGVVGLGGLG-HMAVKFAKAFGVKVTVV 214 Query: 180 AGTEEGQKIVLQ-NGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANV-NLSKDLSLL 237 + + ++ + GAH + + + II+ ++ L +SLL Sbjct: 215 STSPAKKEDAISGLGAHSFILSTDAEQMQAAVGTMDG-----IIDTVSASHPLPPLISLL 269 Query: 238 SHGGRVIVVG-SRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLK 296 G++++VG +E+ + + G + +E Q+ ++ Sbjct: 270 KSHGKLVMVGDPPKPLELPVFPLLLGRKMVAGSAIGG--MKETQEMIDFAAKEGVRADVE 327 Query: 297 PVIGSQYPLEKVAEAHENIIHG 318 + P++ V A + + Sbjct: 328 VI-----PMDYVNTAMQRVSKS 344 >1Q1N-A nrPDB Length = 360 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 60/329 (18%), Positives = 113/329 (34%), Gaps = 54/329 (16%) Query: 31 PIP-KDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDN-ASAFK 88 P P DH + IK+ ACGV + + +G + +P G ++ G + +G S K Sbjct: 28 PKPFYDHDIDIKIEACGVCGSDIHCAAGHWGNMK-MPLVVGHEIVGKVVKLGPKSNSGLK 86 Query: 89 KGDRVFTSSTIS----------------------------------GGYAEYALAADHTV 114 G RV + + GGYA Y +H V Sbjct: 87 VGQRVGVGAQVFSCLECDRCKNDNEPYCTKFVTTYSQPYEDGYVSQGGYANYVRVHEHFV 146 Query: 115 YKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGL 174 +PE + A + T Y L+ + C G+ V + G G I++A G Sbjct: 147 VPIPENIPSHLAAPLLCGGLTVYSPLVRNGC-GPGKKVGIVGLGGIG-SMGTLISKAMGA 204 Query: 175 KILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVN---LS 231 + + + ++ ++ GA E + D+I+ +++ + Sbjct: 205 ETYVISRSSRKREDAMKMGADHYIATLEEGDWGEKYFDT----FDLIVVCASSLTDIDFN 260 Query: 232 KDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGME 291 + GGR++ + E+ K + V++ S ++ L + Sbjct: 261 IMPKAMKVGGRIVSISIPEQHEM----LSLKPYGLKAVSISYSALGSIKEL-NQLLKLVS 315 Query: 292 IGWLKPVIGSQYPLEKV--AEAHENIIHG 318 +K + P+ + EA E + G Sbjct: 316 EKDIKIWVE-TLPVGEAGVHEAFERMEKG 343 >2VNA-A nrPDB Length = 357 Score = 132 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 62/329 (18%), Positives = 126/329 (38%), Gaps = 36/329 (10%) Query: 25 RSDIAVPI-PKDHQVLIKVHACGVNPVETYIR-------SGTYSRKPLLPYTPGSDVAGV 76 ++ +P + QV ++ V+P Y+R Y L G+ Sbjct: 26 MEEVYLPDNINEGQVQVRTLYLSVDP---YMRCRMNEDTGTDYITPWQLSQVVDGGGIGI 82 Query: 77 IEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQG----AAIGIP 132 IE + KGD V + + + +++ K+ +L AIG+P Sbjct: 83 IEE--SKHTNLTKGDFVTSFYWP---WQTKVILDGNSLEKVDPQLVDGHLSYFLGAIGMP 137 Query: 133 YFTAYRALIHSACVKAG--ESVLVHGASGGVGLAACQIARAYGL-KILGTAGTEEGQKIV 189 T+ + + AG ++++V GA+G G A QI G +++G GT E ++ Sbjct: 138 GLTSLIGIQEKGHITAGSNKTMVVSGAAGACGSVAGQIGHFLGCSRVVGICGTHEKCILL 197 Query: 190 L-QNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGS 248 + G N+++ N +++++ G+D+ + + +S ++ +I+ G Sbjct: 198 TSELGFDAAINYKKDNVAEQLRE-SCPAGVDVYFDNVGGNISDTVISQMNENSHIILCGQ 256 Query: 249 RGTIEINPRDTMAKESSIIGV----------TLFSSTKEEFQQYAAALQAGMEIGWLKPV 298 + +I + L + K++F+ L + G LK Sbjct: 257 ISQYNKDVPYPPPLSPAIEAIQKERNITRERFLVLNYKDKFEPGILQLSQWFKEGKLKIK 316 Query: 299 IGSQYPLEKVAEAHENIIHGSGATGKMIL 327 LE + A ++++ G G GK I+ Sbjct: 317 ETVINGLENMGAAFQSMMTG-GNIGKQIV 344 >6C49-A nrPDB Length = 350 Score = 131 bits (330), Expect = 4e-31, Method: Composition-based stats. Identities = 62/326 (19%), Positives = 119/326 (36%), Gaps = 46/326 (14%) Query: 32 IPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGD 91 + HQV +KV CG+ + + + + + P G ++ G I A+G A + G Sbjct: 35 ELQPHQVEVKVEYCGLCHSDISVLNNEWHST-VYPVVAGHEIIGRIVALGSEAKGLQIGQ 93 Query: 92 RVFTSST----------------------------ISGGYAEYALAADHTVYKLPEKLDF 123 RV T +GG+A+ A LPE LD Sbjct: 94 RVGIGWTAESCQACDECIGGQQVLCTGENIATIVGHAGGFADKVRAGWQWAIPLPEDLDP 153 Query: 124 KQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTE 183 + + T + L+ ++A V V G G+G A ++ +A+G +I + Sbjct: 154 ESAGPLLCGGITVFDPLLK-HKIQATHHVGVIGIG-GLGHIAIKLLKAWGCEITAFSSNP 211 Query: 184 EGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLA-NVNLSKDLSLLSHGGR 242 + + + GA V N R+ + + D+++ + +N +S L+ G Sbjct: 212 DKTEELKAMGADHVVNSRDTEAVKA-----QKGKFDLLLSTVNVTLNWRAFISTLAPNGS 266 Query: 243 VIVVGSR-GTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGS 301 + +G + ++ + S+ G S L + P I Sbjct: 267 LHFLGLTLEPVPVSVGSLIDGAKSVTGSPTGS------PAALRQLLKFAARKKIAPQIE- 319 Query: 302 QYPLEKVAEAHENIIHGSGATGKMIL 327 +P+ ++ EA E + G +++L Sbjct: 320 LFPMSQLNEAIERLHSGQARY-RIVL 344 >5VKT-A nrPDB Length = 362 Score = 130 bits (327), Expect = 8e-31, Method: Composition-based stats. Identities = 56/278 (20%), Positives = 103/278 (37%), Gaps = 44/278 (15%) Query: 34 KDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRV 93 D V IKV CG+ + ++ + + P PG +V GV+ VG + FK GD V Sbjct: 33 GDADVTIKVLFCGICHTDLHVIKNEWGN-AMYPVVPGHEVVGVVTDVGHGVTKFKAGDTV 91 Query: 94 FTSSTIS------------------------------------GGYAEYALAADHTVYKL 117 + GG+++ + + V ++ Sbjct: 92 GVGYFVDSCRTCESCSTGHENYCPDLVLTSNGVDHHHHGATTKGGFSDVLVVSQDFVVRV 151 Query: 118 PEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKIL 177 PE L A + T Y + A + G+ + V G G+G A + A+A+G+ + Sbjct: 152 PESLPLDGAAPLLCAGVTVYSPMAQYALNEPGKHLGVVGLG-GLGHMAVKFAKAFGMTVT 210 Query: 178 GTAGTEEGQKIVL-QNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSL 236 + + + L + GA + + + II + A + L+L Sbjct: 211 VISSSPGKRDEALGRLGADAFLVSHDAAQMKAAAATLDG----IIDTVSAGHQIVPLLAL 266 Query: 237 LSHGGRVIVVGSRGT-IEINPRDTMAKESSIIGVTLFS 273 L G+++VVG+ T +E+ + + G + S Sbjct: 267 LKPMGQMVVVGAPSTPLELPAYAIITGGKRVAGNGVGS 304 >2ZB3-A nrPDB Length = 353 Score = 128 bits (322), Expect = 4e-30, Method: Composition-based stats. Identities = 66/341 (19%), Positives = 126/341 (36%), Gaps = 46/341 (13%) Query: 12 RVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIR-------SGTYSRKPL 64 RV EF P+ L + QV ++ V+P Y+R Y Sbjct: 26 RVEEFSLPDALN-----------EGQVQVRTLYLSVDP---YMRCKMNEDTGTDYLAPWQ 71 Query: 65 LPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFK 124 L GV+E KGD V + + A+ + + K+ +L Sbjct: 72 LAQVADGGGIGVVEE--SKHQKLTKGDFVTSFYWP---WQTKAILDGNGLEKVDPQLVDG 126 Query: 125 QG----AAIGIPYFTAYRALIHSACVKAGE--SVLVHGASGGVGLAACQIARAYGL-KIL 177 AIG+P T+ + + AG +++V GA+G G A QI G +++ Sbjct: 127 HLSYFLGAIGMPGLTSLIGVQEKGHISAGSNQTMVVSGAAGACGSLAGQIGHLLGCSRVV 186 Query: 178 GTAGTEEGQKIVL-QNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSL 236 G GT+E + + G N++ N +++++ G+D+ + + + +S Sbjct: 187 GICGTQEKCLFLTSELGFDAAVNYKTGNVAEQLREAC-PGGVDVYFDNVGGDISNAVISQ 245 Query: 237 LSHGGRVIVVGSRGTIEINPRDTMAKESSIIGV----------TLFSSTKEEFQQYAAAL 286 ++ +I+ G + ++ + + K++F+ L Sbjct: 246 MNENSHIILCGQISQYSNDVPYPPPLPPAVEAIRKERNITRERFTVLNYKDKFEPGILQL 305 Query: 287 QAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMIL 327 + G LK LE + A ++++ G G GK I+ Sbjct: 306 SQWFKEGKLKVKETMAKGLENMGVAFQSMMTG-GNVGKQIV 345 >5H83-A nrPDB Length = 360 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 47/272 (17%), Positives = 89/272 (32%), Gaps = 38/272 (13%) Query: 34 KDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRV 93 ++ V KV CG + + + + P+ G ++ GV+ +G FK GD+V Sbjct: 38 GENDVQFKVLYCGTCNYDLEMSTNKFGMTK-YPFVIGHEIVGVVTEIGSKVQKFKVGDKV 96 Query: 94 FTS------------------------------STISGGYAEYALAADHTVYKLPEKLDF 123 GG + + PE L Sbjct: 97 GVGGFVGACEKCEMCVNGVENNCSKVESTDGHFGNNFGGCCNIMVVNEKYAVVWPENLPL 156 Query: 124 KQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGT- 182 G + T Y L K G ++ + G G A + A+A+G K+ + + Sbjct: 157 HSGVPLLCAGITTYSPLRRYGLDKPGLNIGIAGLGGLG-HLAIRFAKAFGAKVTLISSSV 215 Query: 183 EEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGR 242 ++ ++ + + G + + + II M ++ L+LL G+ Sbjct: 216 KKKREALEKFGVDSFLLNSNPEEMQGAYGTLDG----IIDTMPVAHSIVPFLALLKPLGK 271 Query: 243 VIVVGSR-GTIEINPRDTMAKESSIIGVTLFS 273 +I++G E+ + I G S Sbjct: 272 LIILGVPEEPFEVPAPALLMGGKLIAGSAAGS 303 >6DKH-A nrPDB Length = 346 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 56/329 (17%), Positives = 112/329 (34%), Gaps = 54/329 (16%) Query: 39 LIKVHACGVNPVETYIRS----GTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRV- 93 L+++ G+ + + G + K P G +V G + + ++S +G V Sbjct: 34 LVQITRGGICGSDLHYYQEGKVGNFMIKA--PMVLGHEVIGKV--IHSDSSELHEGQTVA 89 Query: 94 ------------------------------FTSSTISGGYAEYALAADHTVYKLPEKLDF 123 + GG+ Y + P K D Sbjct: 90 INPSKPCGHCKYCIEHNENQCTDMRFFGSAMYFPHVDGGFTRYKMVETSQCVPYPAKAD- 148 Query: 124 KQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGL-KILGTAGT 182 ++ A P A A + ++ G+ V + G G +G + G +I+ + Sbjct: 149 EKVMAFAEPLAVAIHAAHQAGELQ-GKRVFISG-VGPIGCLIVSAVKTLGAAEIVCADVS 206 Query: 183 EEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANV-NLSKDLSLLSHGG 241 + + GA + N + + + D+ E+ + +++ L + G Sbjct: 207 PRSLSLGKEMGADVLVNPQNDDMDHW---KAEKGYFDVSFEVSGHPSSVNTCLEVTRARG 263 Query: 242 RVIVVGSRGTI-EINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG 300 ++ VG G + E + KE S+ G F+S EF + L G+ P++ Sbjct: 264 VMVQVGMGGAMAEFPMMTLIGKEISLRGSFRFTS---EFNTAVSWLANGVINPL--PLLS 318 Query: 301 SQYPLEKVAEAHENIIHGSGATGKMILLL 329 ++YP + EA K+ L+ Sbjct: 319 AEYPFTDLEEAL-RFAGDKTQAAKVQLVF 346 >2CF5-A nrPDB Length = 357 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 67/354 (18%), Positives = 119/354 (33%), Gaps = 54/354 (15%) Query: 5 QKLMRAVRV---FEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSR 61 +M A R + P + + V I++ CG+ + + Sbjct: 1 MGIMEAERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGM 60 Query: 62 KPLLPYTPGSDVAGVIEAVGDNASAFKKGDR----------------------------- 92 P PG +V G + VG + S F GD Sbjct: 61 -SNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIW 119 Query: 93 ----VFT-SSTISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVK 147 V+ GG+A+ + V K+PE + +Q A + T Y L H +K Sbjct: 120 SYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHF-GLK 178 Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQ-NGAHEVFNHREVNYI 206 GGVG +IA+A G + + + + ++ LQ GA + + + Sbjct: 179 QPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKM 238 Query: 207 DKIKKYVGEKGIDIIIEML-ANVNLSKDLSLLSHGGRVIVVGSR-GTIEINPRDTMAKES 264 ++ +D +I+ + + L LSLL G++I++G ++ M Sbjct: 239 SEL-----ADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRK 293 Query: 265 SIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHG 318 I G + S ++ L+ E G I ++ V A E + Sbjct: 294 VITGSFIGS-----MKETEEMLEFCKEKGL--SSIIEVVKMDYVNTAFERLEKN 340 >4JLW-A nrPDB Length = 399 Score = 88.1 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 48/259 (18%), Positives = 87/259 (33%), Gaps = 55/259 (21%) Query: 18 GPEVLKLRSDIAVPIPKDHQ-------VLIKVHACGVNPVETYIRSGTYSRKPLLPYTPG 70 GP +++ +I P +D Q V+++V + + + ++ G G Sbjct: 11 GPGKVEV-QNIPYPKMQDPQGRQIDHGVILRVVSTNICGSDQHMVRGR--TTAPEGLVLG 67 Query: 71 SDVAGVIEAVGDNASAFKKGDRVFTSSTIS------------------------------ 100 ++ G + +G K GD V ++ Sbjct: 68 HEITGEVVEIGRGVETMKIGDLVSVPFNVACGHCRTCKEQHTGVCLTVNPARAGGAYGYV 127 Query: 101 ------GGYAEYALAA--DHTVYKLPEKLDFKQ----GAAIGIPYFTAYRALIHSACVKA 148 GG AEY L D + KLP + + + T Y + +A V Sbjct: 128 DMGGWVGGQAEYVLVPYADFNLLKLPNREAAMEKIRDLTCLSDILPTGYHGAV-TAGVGP 186 Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGT-AGTEEGQKIVLQNGAHEVFNHREVNYID 207 G +V + GA G VGLAA AR G ++ + G ++ + Sbjct: 187 GSTVYIAGA-GPVGLAAAASARLLGAAVVIVGDVNPTRLAHAKKQGFEIADLSKDTPLHE 245 Query: 208 KIKKYVGEKGIDIIIEMLA 226 +I +GE +D ++ + Sbjct: 246 QIAALLGEPEVDCAVDAVG 264 >2VWH-A nrPDB Length = 357 Score = 86.2 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 53/355 (14%), Positives = 119/355 (33%), Gaps = 60/355 (16%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLP- 66 M+A+ V E + + P P+ + L++ GV+ + + +G + P Sbjct: 1 MKAIAVKR---GEDRPVVIEKPRPEPESGEALVRTLRVGVDGTDHEVIAGGHGGFPEGED 57 Query: 67 -YTPGSDVAGVIEAVGDNASAFKKGDRVFTSST-------------------ISGGY--- 103 G + GV+ V N + ++GD V + G Y Sbjct: 58 HLVLGHEAVGVV--VDPNDTELEEGDIVVPTVRRPPASGTNEYFERDQPDMAPDGMYFER 115 Query: 104 ---------AEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAG----- 149 +E+ + + + ++P + + P +AL H+ ++ Sbjct: 116 GIVGAHGYMSEFFTSPEKYLVRIPR--SQAELGFLIEPISITEKALEHAYASRSAFDWDP 173 Query: 150 ESVLVHGASGGVGLAACQIARA--YGLKILGT----AGTEEGQKIVLQNGAHEVFNHREV 203 S V G +G +GL + + G + L + I+ + A V + + Sbjct: 174 SSAFVLG-NGSLGLLTLAMLKVDDKGYENLYCLGRRDRPDPTIDIIEELDATYVDSRQT- 231 Query: 204 NYIDKIKKYVGEKGIDIIIEMLA-NVNLSKDLSLLSHGGRVIVVGSRGTIEINP-RDTMA 261 ++ + + +D I E + + + L+ G ++G Sbjct: 232 -PVEDVPDVYEQ--MDFIYEATGFPKHAIQSVQALAPNGVGALLGVPSDWAFEVDAGAFH 288 Query: 262 KESSIIGVTLFSSTKEEFQQYAAALQAGMEIGW--LKPVIGSQYPLEKVAEAHEN 314 +E + L S + + AA ++ L+ ++ +PL + A ++ Sbjct: 289 REMVLHNKALVGSVNSHVEHFEAATVTFTKLPKWFLEDLVTGVHPLSEFEAAFDD 343 >1KOL-A nrPDB Length = 398 Score = 83.1 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 44/235 (18%), Positives = 77/235 (32%), Gaps = 47/235 (20%) Query: 35 DHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVF 94 +H V++KV + + + ++ G + G ++ G + G + + GD V Sbjct: 33 EHGVILKVVSTNICGSDQHMVRGR--TTAQVGLVLGHEITGEVIEKGRDVENLQIGDLVS 90 Query: 95 TSST------------------------------------ISGGYAEYALAA--DHTVYK 116 +GG AEY L D + K Sbjct: 91 VPFNVACGRCRSCKEMHTGVCLTVNPARAGGAYGYVDMGDWTGGQAEYVLVPYADFNLLK 150 Query: 117 LPEKLDFKQ----GAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAY 172 LP++ + + T Y + +A V G +V V GA G VGLAA AR Sbjct: 151 LPDRDKAMEKIRDLTCLSDILPTGYHGAV-TAGVGPGSTVYVAGA-GPVGLAAAASARLL 208 Query: 173 GLKILGT-AGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLA 226 G ++ G + ++I +GE +D ++ + Sbjct: 209 GAAVVIVGDLNPARLAHAKAQGFEIADLSLDTPLHEQIAALLGEPEVDCAVDAVG 263 >2DPH-A nrPDB Length = 398 Score = 82.0 bits (201), Expect = 4e-16, Method: Composition-based stats. Identities = 70/391 (17%), Positives = 125/391 (31%), Gaps = 91/391 (23%) Query: 9 RAVRVFEFGGPEVLKLRSDIAVPIPK--------DHQVLIKVHACGVNPVETYIRSGTYS 60 ++V G L++ + VP PK +H V++KV + + + +I G + Sbjct: 4 KSVVYH---GTRDLRVET---VPYPKLEHNNRKLEHAVILKVVSTNICGSDQHIYRGRFI 57 Query: 61 RKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSST---------------------- 98 + G ++ G + G + GD V Sbjct: 58 VPKG--HVLGHEITGEVVEKGSDVELMDIGDLVSVPFNVACGRCRNCKEARSDVCENNLV 115 Query: 99 ---------------ISGGYAEYALAA--DHTVYKLPEKLDFKQ----GAAIGIPYFTAY 137 SGG AEY L D+ + K +K + I T + Sbjct: 116 NPDADLGAFGFDLKGWSGGQAEYVLVPYADYMLLKFGDKEQAMEKIKDLTLISDILPTGF 175 Query: 138 RALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLK-ILGTAGTEEGQKIVLQNGAHE 196 + SA VK G V + GA G VG A AR G ++ E K++ G E Sbjct: 176 HGCV-SAGVKPGSHVYIAGA-GPVGRCAAAGARLLGAACVIVGDQNPERLKLLSDAGF-E 232 Query: 197 VFNHREVNYI-DKIKKYVGEKGIDIIIEMLA---------------NVNLSKDLSLLSHG 240 + R + D+I + +G+ +D ++ + N L+ ++ G Sbjct: 233 TIDLRNSAPLRDQIDQILGKPEVDCGVDAVGFEAHGLGDEANTETPNGALNSLFDVVRAG 292 Query: 241 GRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIG 300 G + + G + +P + A + TK A + ++ Sbjct: 293 GAIGIPGIYVGSDPDPVNKDAGSGRLHLDFGKMWTKSIRIMTGMAPVTNYNRHLTEAILW 352 Query: 301 SQYP------------LEKVAEAHENIIHGS 319 Q P L++ + + GS Sbjct: 353 DQMPYLSKVMNIEVITLDQAPDGYAKFDKGS 383 >2CDC-A nrPDB Length = 366 Score = 61.5 bits (148), Expect = 5e-10, Method: Composition-based stats. Identities = 63/376 (16%), Positives = 122/376 (32%), Gaps = 67/376 (17%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYS----RKP 63 M+A+ V +K + + + I+ G+ + I +G + K Sbjct: 1 MKAIIVKPPNAGVQVKDVDEKKLDSYGK--IKIRTIYNGICGADREIVNGKLTLSTLPKG 58 Query: 64 LLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALA-------------- 109 G + GV+E + F +GD V + G L Sbjct: 59 KDFLVLGHEAIGVVEE---SYHGFSQGDLVMPVNRRGCGICRNCLVGRPDFCETGEFGEA 115 Query: 110 ---------------ADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAG----- 149 + K+P+ + + P +++ V+ Sbjct: 116 GIHKMDGFMREWWYDDPKYLVKIPK--SIEDIGILAQPLADIEKSIEEILEVQKRVPVWT 173 Query: 150 --------ESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHR 201 VLV G +G +G+ + R YGL++ E + + + Sbjct: 174 CDDGTLNCRKVLVVG-TGPIGVLFTLLFRTYGLEVWMANRREPTEVEQTVIEETKTNYYN 232 Query: 202 EVNYIDKIKKYVGEKGIDIIIEMLANVN--LSKDLSLLSHGGRVIVVG--SRGTIEIN-- 255 N DK+K VG+ D+II+ L + LL G + + G + G++ ++ Sbjct: 233 SSNGYDKLKDSVGK--FDVIIDATGADVNILGNVIPLLGRNGVLGLFGFSTSGSVPLDYK 290 Query: 256 -PRDTMAKESSIIGVTLFSSTKEEFQQYAAALQA--GMEIGWLKPVIGSQYPLEKVAEAH 312 ++ + +IIG L + K FQQ L + + K +I + E Sbjct: 291 TLQEIVHTNKTIIG--LVNGQKPHFQQAVVHLASWKTLYPKAAKMLITKTVSINDEKELL 348 Query: 313 ENIIHGSGATGKMILL 328 + + K+ +L Sbjct: 349 KVLREKEHGEIKIRIL 364 >3WID-A nrPDB Length = 369 Score = 51.5 bits (122), Expect = 6e-07, Method: Composition-based stats. Identities = 47/369 (12%), Positives = 105/369 (28%), Gaps = 62/369 (16%) Query: 8 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSG----TYSRKP 63 M + P+ + I +P P+ ++ +K G+ + +G TY+ + Sbjct: 1 MSTINAIVTDAPKGGVKYTKIDMPEPEKYEAKLKPVYIGICGTDRGEVAGALSFTYNPEG 60 Query: 64 LLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISG---------------------- 101 G + + V + + K+GD V G Sbjct: 61 ENFLVLGHEALLQVLDV-SDNNYIKRGDFVVPLVRRPGKCVNCRIGRQDNCSIGDPDKHE 119 Query: 102 -------GYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKA------ 148 G+ + D D + A + P +A V Sbjct: 120 AGITGLHGFMRDVIYDDIQNLVKVNDPDLGKIAVLTEPLKNVMKAFEVFDVVSKRSIFQN 179 Query: 149 ------GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHRE 202 G+ ++V G SG + + G + +E + + + Sbjct: 180 DDSTFIGKKMVVIG-SGSEAFLYSFVGKDRGFDVTMVNRHDETENKMKMM------DDFG 232 Query: 203 VNYIDKIKKYVGEKGIDIIIEMLA-NVNLSKDLSLLSHGGRVIVVGSRGTIEI------N 255 V + + +K ID++++ + K + +++ G VI+ G G + Sbjct: 233 VGFSNYLKDM--PDKIDLLVDTSGDPSTIFKFVKKVNNNGVVILFGFNGKAPGYPVNGED 290 Query: 256 PRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENI 315 + + +I G + + + +K +I + E+ + Sbjct: 291 IDYIVERNITIAGSVDAAKIHYVQALDSLSNWYHRHPQTIKDIITYEAKPEETNIFFQKP 350 Query: 316 IHGSGATGK 324 K Sbjct: 351 KGEIKTVIK 359 >3RSH-A nrPDB Length = 251 Score = 42.3 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 24/85 (28%), Positives = 39/85 (45%), Gaps = 6/85 (7%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQ----KIVLQNGAHEVFNHREV 203 G+ LV GAS G+G A ++ G K++GTA +E G + NG N Sbjct: 11 EGKVALVTGASRGIGKAIAELLAERGAKVIGTATSESGAQAISDYLGDNGKGMALNVTNP 70 Query: 204 NYIDKIKKYVGE--KGIDIIIEMLA 226 I+ + K + + G+DI++ Sbjct: 71 ESIEAVLKAITDEFGGVDILVNNAG 95 >3D3W-A nrPDB Length = 244 Score = 42.3 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 20/96 (20%), Positives = 38/96 (39%), Gaps = 5/96 (5%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQ--NGAH-EVFNHREVN 204 AG VLV GA G+G Q A G +++ + T+ +++ G + + Sbjct: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWE 65 Query: 205 YIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG 240 ++ VG +D+++ A L L + Sbjct: 66 ATERALGSVGP--VDLLVNNAAVALLQPFLEVTKEA 99 >4INE-A nrPDB Length = 454 Score = 40.7 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 21/113 (18%), Positives = 46/113 (40%), Gaps = 9/113 (7%) Query: 140 LIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFN 199 + K G+++L G G+G A Q+A +G+ + G + I L+ E + Sbjct: 233 IKRFGDFKPGQTMLDIGV--GIGGGARQVADEFGVHVHGIDLSSNMLAIALERLHEEKDS 290 Query: 200 HREVNYIDKIKKYVGEKGIDIII--EMLANVN-----LSKDLSLLSHGGRVIV 245 + + D + + D + + + ++ S+ L GG+V++ Sbjct: 291 RVKYSITDALVYQFEDNSFDYVFSRDCIQHIPDTEKLFSRIYKALKPGGKVLI 343 >3DWF-A nrPDB Length = 276 Score = 40.0 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 6/52 (11%) Query: 148 AGESVLVHGASGGVG-LAACQIARAYGLKILGTAGTEEGQ----KIVLQNGA 194 G+ V+V GAS G+G A +A+ G ++ TA ++E L+ GA Sbjct: 10 QGKKVIVTGASKGIGREIAYHLAK-MGAHVVVTARSKEALQKVVARCLELGA 60 >5TQV-A nrPDB Length = 233 Score = 40.0 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 15/78 (19%), Positives = 34/78 (43%), Gaps = 1/78 (1%) Query: 150 ESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAH-EVFNHREVNYIDK 208 ++VL+ GAS G+G + + G ++ TA + + GAH + + I Sbjct: 10 KTVLIVGASRGLGREFVRQYQRDGWNVIATARDDASLAALRALGAHAHALDITQPEQIAA 69 Query: 209 IKKYVGEKGIDIIIEMLA 226 + + + +D+ + + Sbjct: 70 LGWKLDGERLDVAVVVSG 87 >3F9I-A nrPDB Length = 249 Score = 39.2 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 13/45 (28%), Positives = 22/45 (48%), Gaps = 3/45 (6%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNG 193 G++ L+ GAS G+G A ++ G K++ + EE G Sbjct: 14 GKTSLITGASSGIGSAIARLLHKLGSKVIISGSNEEKL---KSLG 55 >4LIS-A nrPDB Length = 371 Score = 38.4 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 19/108 (17%), Positives = 34/108 (31%), Gaps = 10/108 (9%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYID 207 SVLV G +G +G G K++ L E+ + ++ + Sbjct: 2 PSGSVLVTGGTGYIGSFTTLALLEAGYKVVVADNLYNSSAEALNR--IELISGKKAEFAQ 59 Query: 208 KIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEIN 255 E D + E D+ + H + VG G ++ Sbjct: 60 --LDVTDEAAFDKVFEA------HPDIDSVIHFAALKAVGESGEKPLD 99 >1Q7C-A nrPDB Length = 244 Score = 38.0 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 21/78 (26%), Positives = 36/78 (46%), Gaps = 8/78 (10%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYID 207 G+ LV GAS G+G A + A G K++GTA + +NGA + ++ N Sbjct: 4 EGKIALVTGASRGIGRAIAETLAARGAKVIGTATS--------ENGAQAISDYLGANGKG 55 Query: 208 KIKKYVGEKGIDIIIEML 225 + I+ ++E + Sbjct: 56 LMLNVTDPASIESVLEKI 73 >5YWN-A nrPDB Length = 334 Score = 37.3 bits (85), Expect = 0.009, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 29/58 (50%), Gaps = 1/58 (1%) Query: 151 SVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDK 208 SV V GA+G + + + G K++G+ +EE + + + F++ V +++ Sbjct: 4 SVFVSGATGYLAQQIIALVLSKGYKVVGSVRSEEKGANLKKLYGDD-FSYEVVKVLEQ 60 >3VZS-A nrPDB Length = 257 Score = 37.3 bits (85), Expect = 0.009, Method: Composition-based stats. Identities = 20/85 (23%), Positives = 33/85 (38%), Gaps = 14/85 (16%) Query: 154 VHGASGGVGLAACQIARAYGLKILGTAG-----TEEGQKIVLQNGAHEVF---NHREVNY 205 V G GG+G A CQ G +++ G E+ + G + N + + Sbjct: 19 VTGGMGGIGTAICQRLAKDGFRVVAGCGPNSPRREKWLEQQKALGFDFIASEGNVADWDS 78 Query: 206 ID----KIKKYVGEKGIDIIIEMLA 226 K+K VGE +D++I Sbjct: 79 TKTAFDKVKSEVGE--VDVLINNAG 101 >5PGZ-A nrPDB Length = 276 Score = 37.3 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 17/51 (33%), Positives = 25/51 (49%), Gaps = 4/51 (7%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKI----VLQNGA 194 G+ V+V GAS G+G G ++ TA +EEG + L+ GA Sbjct: 17 QGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGA 67 >5T5Q-A nrPDB Length = 247 Score = 37.3 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 18/87 (20%), Positives = 33/87 (37%), Gaps = 8/87 (9%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQ-KIVLQNG-----AHEVFNHR 201 ++++ GA+GG+G A ++ A G ++ T EG G A + Sbjct: 8 ENRTLVLTGANGGIGRAIAELFHASGANLVLTDLDREGLDAFAASLGSPERIATIKADAS 67 Query: 202 EVNYIDKIKKYVGE--KGIDIIIEMLA 226 + +K E GID ++ Sbjct: 68 SADDAEKTVALAMERFGGIDFLVPSAG 94 >5B6K-A nrPDB Length = 366 Score = 37.3 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 14/81 (17%), Positives = 27/81 (33%), Gaps = 11/81 (13%) Query: 151 SVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQN---GAHEVFNHREVNYID 207 +V V GA+G + + K++G+ + E + G FN+ + Sbjct: 23 TVFVSGATGFIAQHVVRQLLDQNYKVIGSVRSAEKGDHLKNVIFKGGD--FNY------E 74 Query: 208 KIKKYVGEKGIDIIIEMLANV 228 +K D + E Sbjct: 75 IVKDISDPTAFDHVFEKHGKD 95 >3EMK-A nrPDB Length = 246 Score = 36.9 bits (84), Expect = 0.012, Method: Composition-based stats. Identities = 19/84 (22%), Positives = 33/84 (39%), Gaps = 6/84 (7%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQ-KIVLQNGAHEVF---NHREVN 204 G LV GA+GG+G A + A G + EE ++ + G N + Sbjct: 7 GRKALVTGATGGLGEAIARALHAQGAIVGLHGTREEKLKELAAELGERIFVFPANLSDRE 66 Query: 205 YIDKIKKYVGE--KGIDIIIEMLA 226 + + + E G+DI++ Sbjct: 67 AVKALGQKAEEEMGGVDILVNNAG 90 >1XLT-A nrPDB Length = 384 Score = 36.5 bits (83), Expect = 0.015, Method: Composition-based stats. Identities = 15/58 (25%), Positives = 24/58 (41%), Gaps = 1/58 (1%) Query: 136 AYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNG 193 A+ ++ +A VLV G G GL A A+ G ++ T ++ V G Sbjct: 159 AFPMMMTAAGTVPPARVLVFG-VGVAGLQAIATAKRLGAVVMATDVRAATKEQVESLG 215 >4DIO-A nrPDB Length = 405 Score = 36.1 bits (82), Expect = 0.021, Method: Composition-based stats. Identities = 17/74 (22%), Positives = 26/74 (35%), Gaps = 1/74 (1%) Query: 136 AYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAH 195 A ++ +A + V GA G GL A AR G + T ++ V GA Sbjct: 177 ALPMMMTAAGTVPAAKIFVMGA-GVAGLQAIATARRLGAVVSATDVRPAAKEQVASLGAK 235 Query: 196 EVFNHREVNYIDKI 209 + E + Sbjct: 236 FIAVEDEEFKAAET 249 >3GRP-A nrPDB Length = 266 Score = 36.1 bits (82), Expect = 0.022, Method: Composition-based stats. Identities = 20/84 (23%), Positives = 33/84 (39%), Gaps = 6/84 (7%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQ-KIVLQNGAHEVF---NHREVN 204 G LV GA+GG+G A + A G + E+ +I G N + Sbjct: 27 GRKALVTGATGGIGEAIARCFHAQGAIVGLHGTREDKLKEIAADLGKDVFVFSANLSDRK 86 Query: 205 YIDKIKKYVGE--KGIDIIIEMLA 226 I ++ + +GIDI++ Sbjct: 87 SIKQLAEVAEREMEGIDILVNNAG 110 >5ILO-A nrPDB Length = 271 Score = 36.1 bits (82), Expect = 0.023, Method: Composition-based stats. Identities = 22/123 (17%), Positives = 45/123 (36%), Gaps = 12/123 (9%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDK 208 G++ +V G +GG+GL + A G + ++ + ++ A + + Sbjct: 15 GKNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEFVKLRAAH----PTQSVMII 70 Query: 209 IKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIG 268 +KG++ E +A + D+ V+ V + R + II Sbjct: 71 KMDVANKKGVEATYEEIAKTFGNIDI--------VVNVAGIFNDKDVQRTLLVNLGGIIN 122 Query: 269 VTL 271 TL Sbjct: 123 STL 125 >3PWS-A nrPDB Length = 366 Score = 35.7 bits (81), Expect = 0.028, Method: Composition-based stats. Identities = 21/113 (18%), Positives = 42/113 (37%), Gaps = 7/113 (6%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDK 208 G +V V GA+G VG ++ L I ++ + + A + ++ + + Sbjct: 2 GYTVAVVGATGAVGAQMIKMLEESTLPI------DKIRYLASARSAGKSLKFKDQDITIE 55 Query: 209 IKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMA 261 +G+DI + + +K G V+VV + NP + Sbjct: 56 ETTETAFEGVDIALFSAGSSTSAKYAPYAVKAG-VVVVDNTSYFRQNPDVPLV 107 >4M8S-A nrPDB Length = 248 Score = 35.7 bits (81), Expect = 0.029, Method: Composition-based stats. Identities = 24/86 (27%), Positives = 37/86 (43%), Gaps = 9/86 (10%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQK-----IVLQNGAHEVFNHREV 203 G+ LV GAS G+G A A G K++GTA +E G + G V N E Sbjct: 8 GKIALVTGASRGIGAAIADTLAAAGAKVIGTATSESGAAAISERLAQWGGEGRVLNSAEP 67 Query: 204 NYIDKI---KKYVGEKGIDIIIEMLA 226 ++ + + K +DI++ Sbjct: 68 ETVENLIADIEKTFGK-LDILVNNAG 92 >5JJC-A nrPDB Length = 342 Score = 35.7 bits (81), Expect = 0.030, Method: Composition-based stats. Identities = 12/59 (20%), Positives = 27/59 (45%), Gaps = 4/59 (6%) Query: 142 HSACVKAGESVLVHGASGGVGLAACQIARAYGLK---ILGTAGTEEGQKIVLQNGAHEV 197 ++ G V+V G +G G+ +A+A G + ++ ++E + + GA + Sbjct: 55 KRGLLRPGG-VIVEGTAGNTGIGLTMVAKALGYRTAIVIPETASQEKKDALRLLGAELI 112 >4KRI-A nrPDB Length = 433 Score = 35.3 bits (80), Expect = 0.035, Method: Composition-based stats. Identities = 22/113 (19%), Positives = 42/113 (37%), Gaps = 9/113 (7%) Query: 140 LIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFN 199 L +K G+ +L G G+G A Q A +GL++ G + + L+ E Sbjct: 214 LKRFGPMKTGQRMLDIGV--GIGGGARQAASEFGLQVHGVDLSTNMLAVALERVHKEKDA 271 Query: 200 HREVNYIDKIKKYVGEKGIDIII--EMLANVN-----LSKDLSLLSHGGRVIV 245 D + D + + + ++ S+ L GG+V++ Sbjct: 272 RVTYAVCDACEYEFEPNSFDYVFSRDCIQHIKDTDKLFSRIYRALKPGGKVLI 324 >5YSS-A nrPDB Length = 256 Score = 35.3 bits (80), Expect = 0.037, Method: Composition-based stats. Identities = 19/85 (22%), Positives = 35/85 (41%), Gaps = 7/85 (8%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKIL--GTAGTEEGQKIVLQNGAH---EVFNHREV 203 G++ LV G++ G+GL Q+ G ++ G + + V Q G + + Sbjct: 5 GKTALVTGSTSGIGLGIAQVLAQAGATLILNGFGDVDAAKDAVAQYGKTPGYHGADLSDE 64 Query: 204 NYIDKIKKYVGE--KGIDIIIEMLA 226 I + +Y G+DI+I Sbjct: 65 AQIADMMRYAESEFGGVDILINNAG 89 >1X14-A nrPDB Length = 401 Score = 35.0 bits (79), Expect = 0.042, Method: Composition-based stats. Identities = 21/92 (22%), Positives = 33/92 (35%), Gaps = 16/92 (17%) Query: 127 AAIGIPYFTAYRALIHSA--------------CVKAGESVLVHGASGGVGLAACQIARAY 172 A + YRA++ +A V+V GA G GLAA A + Sbjct: 136 ALSSMANIAGYRAIVEAAHEFGRFFTGQITAAGKVPPAKVMVIGA-GVAGLAAIGAANSL 194 Query: 173 GLKILGTAGTEEGQKIVLQNGAHEV-FNHREV 203 G + E ++ V GA + + +E Sbjct: 195 GAIVRAFDTRPEVKEQVQSMGAEFLELDFKEE 226 >3LLV-A nrPDB Length = 141 Score = 35.0 bits (79), Expect = 0.044, Method: Composition-based stats. Identities = 13/74 (17%), Positives = 34/74 (45%), Gaps = 7/74 (9%) Query: 150 ESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVF-NHREVNYIDK 208 E +++ + GVGL + A G K+L ++E +++ G V + + ++ Sbjct: 8 EYIVIGSEAAGVGL--VRELTAAGKKVLAVDKSKEKIELLEDEGFDAVIADPTDESF--- 62 Query: 209 IKKYVGEKGIDIII 222 + + +G+ ++ Sbjct: 63 -YRSLDLEGVSAVL 75 >5CDY-A nrPDB Length = 244 Score = 35.0 bits (79), Expect = 0.045, Method: Composition-based stats. Identities = 20/75 (26%), Positives = 33/75 (44%), Gaps = 8/75 (10%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYID 207 G+ LV GAS G+G A ++ G ++GTA +E+ GA + + N Sbjct: 4 EGKIALVTGASRGIGRAIAELLVERGACVIGTATSEK--------GAEAISAYLGENGKG 55 Query: 208 KIKKYVGEKGIDIII 222 + V ID ++ Sbjct: 56 LMLNVVDPTSIDTVL 70 >2YFH-A nrPDB Length = 448 Score = 34.6 bits (78), Expect = 0.060, Method: Composition-based stats. Identities = 34/252 (13%), Positives = 73/252 (28%), Gaps = 30/252 (11%) Query: 80 VGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYR- 138 +G + GD + I Y +Y + G ++ P T Y Sbjct: 156 IGPDI-DVPAGDLGVGAREIGYMYGQYRKIVGGFYNGVLTGKARSFGGSLIRPEATGYGL 214 Query: 139 ------ALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGT---------- 182 L G V V G SG V A + A +G +++ + + Sbjct: 215 VYFTEAMLKRHGMGFEGMRVSVSG-SGNVAQYAIEKAMEFGARVITASDSSGTVVDESGF 273 Query: 183 -EEGQKIVLQNGAH---EVFNH-REVNYIDKIKKYVGEKGIDIIIEMLANVNL--SKDLS 235 +E +++ A V ++ +E + + +DI + L Sbjct: 274 TKEKLARLIEIKASRDGRVADYAKEFGLVYLEGQQPWSLPVDIALPCATQNELDVDAAHQ 333 Query: 236 LLSHGGRVIVVGSRGTIEINPRDTMAKESSII----GVTLFSSTKEEFQQYAAALQAGME 291 L+++G + + G+ I + + + + A + G + Sbjct: 334 LIANGVKAVAEGANMPTTIEATELFQQAGVLFAPGKAANAGGVATSGLEMAQNAARLGWK 393 Query: 292 IGWLKPVIGSQY 303 + + Sbjct: 394 AEKVDARLHHIM 405 >3NWN-A nrPDB Length = 359 Score = 34.6 bits (78), Expect = 0.062, Method: Composition-based stats. Identities = 19/130 (14%), Positives = 48/130 (36%), Gaps = 11/130 (8%) Query: 197 VFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINP 256 V N+++ ++ K+ + + D++ E +A +S+ L + G ++ G G Sbjct: 64 VVNNQQTDWSFKLDGVLHDASQDLVYETVAKDVVSQALD--GYNGTIMCYGQTGA----- 116 Query: 257 RDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENII 316 K +++G T + + + +E + LE E+ +++ Sbjct: 117 ----GKTYTMMGATENYKHRGILPRALQQVFRMIEERPTHAITVRVSYLEIYNESLFDLL 172 Query: 317 HGSGATGKMI 326 G + Sbjct: 173 STLPYVGPSV 182 >3PPI-A nrPDB Length = 281 Score = 34.6 bits (78), Expect = 0.070, Method: Composition-based stats. Identities = 27/149 (18%), Positives = 55/149 (36%), Gaps = 6/149 (4%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEG-QKIVLQNG--AHEVF-NHREV 203 G S +V G +GG+G A + A GL ++ E + + + G A V N Sbjct: 29 EGASAIVSGGAGGLGEATVRRLHADGLGVVIADLAAEKGKALADELGNRAEFVSTNVTSE 88 Query: 204 NYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRG-TIEINPRDTMAK 262 + + + + G + ++A+ ++ G +G TI++ T Sbjct: 89 DSVLAAIEAANQLG-RLRYAVVAHGGFGVAQRIVQRDGSPADMGGFTKTIDLYLNGTYNV 147 Query: 263 ESSIIGVTLFSSTKEEFQQYAAALQAGME 291 + + +E ++ A L A + Sbjct: 148 ARLVAASIAAAEPRENGERGALVLTASIA 176 >1CYD-A nrPDB Length = 244 Score = 34.2 bits (77), Expect = 0.071, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 34/95 (35%), Gaps = 5/95 (5%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQ-KIVLQN-GAH-EVFNHREVNY 205 G LV GA G+G + A G K++ T + + G + + + Sbjct: 7 GLRALVTGAGKGIGRDTVKALHASGAKVVAVTRTNSDLVSLAKECPGIEPVCVDLGDWDA 66 Query: 206 IDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG 240 +K G +D+++ A V + L + Sbjct: 67 TEKALG--GIGPVDLLVNNAALVIMQPFLEVTKEA 99 >1DIR-A nrPDB Length = 241 Score = 34.2 bits (77), Expect = 0.073, Method: Composition-based stats. Identities = 15/77 (19%), Positives = 29/77 (37%), Gaps = 1/77 (1%) Query: 152 VLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQN-GAHEVFNHREVNYIDKIK 210 VLV+G G +G Q RA + E + + F + ++ Sbjct: 10 VLVYGGRGALGSRCVQAFRARNWWVASIDVVENEEASASVIVKMTDSFTEQADQVTAEVG 69 Query: 211 KYVGEKGIDIIIEMLAN 227 K +G++ +D I+ + Sbjct: 70 KLLGDQKVDAILCVAGG 86 >3RWB-A nrPDB Length = 247 Score = 34.2 bits (77), Expect = 0.079, Method: Composition-based stats. Identities = 22/91 (24%), Positives = 34/91 (37%), Gaps = 10/91 (10%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQ--------KIVLQNGAHEVFN 199 AG++ LV GA+ G+G A A G ++ + EG K A Sbjct: 5 AGKTALVTGAAQGIGKAIAARLAADGATVIVSDINAEGAKAAAASIGKKARAIAADISDP 64 Query: 200 HREVNYIDKIKKYVGEKGIDIIIEMLANVNL 230 +I+ G GIDI++ + V Sbjct: 65 GSVKALFAEIQALTG--GIDILVNNASIVPF 93 >4IIN-A nrPDB Length = 271 Score = 34.2 bits (77), Expect = 0.083, Method: Composition-based stats. Identities = 19/98 (19%), Positives = 39/98 (39%), Gaps = 10/98 (10%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKI-LGTAGTEEGQKIVL----QNGAHEVF----N 199 G++VL+ GAS G+G + + GLK+ + E + + G Sbjct: 29 GKNVLITGASKGIGAEIAKTLASMGLKVWINYRSNAEVADALKNELEEKGYKAAVIKFDA 88 Query: 200 HREVNYIDKIKKYV-GEKGIDIIIEMLANVNLSKDLSL 236 E ++I+ I+ V + G+ ++ V + + Sbjct: 89 ASESDFIEAIQTIVQSDGGLSYLVNNAGVVRDKLAIKM 126 >4HP8-A nrPDB Length = 247 Score = 34.2 bits (77), Expect = 0.087, Method: Composition-based stats. Identities = 19/83 (22%), Positives = 37/83 (44%), Gaps = 6/83 (7%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGT--EEGQKIVLQNGAHEVFNHREVNY 205 G LV GA+ G+G A A G +++ A +E I+ ++G + + +++ Sbjct: 8 EGRKALVTGANTGLGQAIAVGLAAAGAEVVCAARRAPDETLDIIAKDGGNA--SALLIDF 65 Query: 206 IDKI--KKYVGEKGIDIIIEMLA 226 D + K + G DI++ Sbjct: 66 ADPLAAKDSFTDAGFDILVNNAG 88 >1ZZE-A nrPDB Length = 342 Score = 33.4 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 22/91 (24%), Positives = 37/91 (40%), Gaps = 3/91 (3%) Query: 139 ALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVF 198 A I +A + G VLV GA+G V + +G K+ GTA + + + + Sbjct: 1 AKIDNAVLPEGSLVLVTGANGFVASHVVEQLLEHGYKVRGTARSASKLANLQKRWDAKYP 60 Query: 199 NHREVNYIDKIKKYVGEKGIDIIIEMLANVN 229 E ++ + K D +I+ A V Sbjct: 61 GRFETAVVEDMLKQ---GAYDEVIKGAAGVA 88 >4BO1-A nrPDB Length = 269 Score = 33.4 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 28/150 (18%), Positives = 54/150 (36%), Gaps = 19/150 (12%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYID 207 G+ LV GAS G+G A G ++GTA + G + I Sbjct: 26 QGKVALVTGASRGIGQAIALELGRLGAVVIGTATSASGAEK-----------------IA 68 Query: 208 KIKKYVGEKGIDIIIEMLANVNLSKDLSLLSH--GGRVIVVGSRGTIEINPRDTMAKESS 265 + K G +G +++++ ++ +++ L + G +IVV + G N M + Sbjct: 69 ETLKANGVEGAGLVLDVSSDESVAATLEHIQQHLGQPLIVVNNAGITRDNLLVRMKDDEW 128 Query: 266 IIGVTLFSSTKEEFQQYAAALQAGMEIGWL 295 V ++ + G + Sbjct: 129 FDVVNTNLNSLYRLSKAVLRGMTKARWGRI 158 >4LMA-A nrPDB Length = 326 Score = 33.4 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 18/90 (20%), Positives = 31/90 (34%), Gaps = 4/90 (4%) Query: 126 GAAIGIPYFTAYRALIHSACV-KAGESVLVHGASGGVGLAACQIARAYGLKILGT---AG 181 A++ T A + +VLV SG G+A A A G +++ T Sbjct: 49 AASVKDRIGTHMINSAEKAGLINPETTVLVEPTSGNTGIALAMTAAAKGYRLILTMPETM 108 Query: 182 TEEGQKIVLQNGAHEVFNHREVNYIDKIKK 211 + E + ++ GA I + Sbjct: 109 SLERRAMLKAYGATLELTPGSQGMKGAILR 138 >1BW9-B nrPDB Length = 356 Score = 33.4 bits (75), Expect = 0.15, Method: Composition-based stats. Identities = 18/84 (21%), Positives = 27/84 (32%), Gaps = 9/84 (10%) Query: 122 DFKQGAAIGIPYFTAYRAL--------IHSACVKAGESVLVHGASGGVGLAACQIARAYG 173 ++G A + TA G +VLV G G VG + +A G Sbjct: 141 SLERGGAGSSAFTTAVGVFEAMKATVAHRGLGSLDGLTVLVQGL-GAVGGSLASLAAEAG 199 Query: 174 LKILGTAGTEEGQKIVLQNGAHEV 197 ++L E + G V Sbjct: 200 AQLLVADTDTERVAHAVALGHTAV 223 >5TVL-A nrPDB Length = 287 Score = 33.4 bits (75), Expect = 0.15, Method: Composition-based stats. Identities = 21/143 (14%), Positives = 49/143 (34%), Gaps = 10/143 (6%) Query: 180 AGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLA---NVNLSKDLSL 236 +E + GA ++ + +K E G +I + + + K Sbjct: 131 DKAKEVLEKAKAEGADFAQLAKDNSTDEK----TKENGGEITFDSASTEVPEQVKKAAFA 186 Query: 237 LSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLK 296 L G V+ + GT + + + K + + +E + Q + +++ Sbjct: 187 LDVDGVSDVITATGTQAYSSQYYIVKLTKKTEKSSNIDDYKEKLKTVILTQKQNDSTFVQ 246 Query: 297 PVIGSQYPLEKVA---EAHENII 316 +IG + + +A +NI Sbjct: 247 SIIGKELQAANIKVKDQAFQNIF 269 >4OAU-C nrPDB Length = 699 Score = 33.0 bits (74), Expect = 0.16, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 30/71 (42%), Gaps = 1/71 (1%) Query: 165 ACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDI-IIE 223 A + G + T+E Q+ + + GA + + E +++ +K + E G D+ + Sbjct: 120 ALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACD 179 Query: 224 MLANVNLSKDL 234 + L L Sbjct: 180 NMGRNALIHAL 190 >1BDB-A nrPDB Length = 277 Score = 33.0 bits (74), Expect = 0.17, Method: Composition-based stats. Identities = 13/50 (26%), Positives = 21/50 (42%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVF 198 GE+VL+ G + G+G A A G K+ + E + + V Sbjct: 5 GEAVLITGGASGLGRALVDRFVAEGAKVAVLDKSAERLAELETDHGDNVL 54 >1HXH-A nrPDB Length = 253 Score = 33.0 bits (74), Expect = 0.18, Method: Composition-based stats. Identities = 13/47 (27%), Positives = 22/47 (46%), Gaps = 1/47 (2%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEG-QKIVLQNG 193 G+ LV G + GVGL ++ G K+ + E Q++ + G Sbjct: 5 QGKVALVTGGASGVGLEVVKLLLGEGAKVAFSDINEAAGQQLAAELG 51 >4R1U-A nrPDB Length = 349 Score = 32.6 bits (73), Expect = 0.21, Method: Composition-based stats. Identities = 19/96 (19%), Positives = 35/96 (36%), Gaps = 4/96 (4%) Query: 138 RALIHSACVKAGE-SVLVHGASGGVGLAACQIARAYGLKILGTAGTEE--GQKIVLQN-G 193 L +++ V G+ +V V GA G + ++ G + GT E + + G Sbjct: 15 SCLDNTSSVSGGDQTVCVTGAGGFIASWLVKLLLERGYTVRGTVRNPEDPKNGHLKELEG 74 Query: 194 AHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVN 229 A E +V+ +D G + + V Sbjct: 75 ARERLTLHKVDLLDLQSIQSVVHGCHGVFHTASPVT 110 >3GDF-A nrPDB Length = 267 Score = 32.6 bits (73), Expect = 0.24, Method: Composition-based stats. Identities = 18/111 (16%), Positives = 41/111 (36%), Gaps = 5/111 (4%) Query: 135 TAYRALIHSACVKAGESVLVHGASG--GVGLAACQIARAYGLKILGT--AGTEEGQKIVL 190 T + +L+ +K G+ V+V GASG G+G+ A + G + T + + ++ V Sbjct: 7 TKHESLLDQLSLK-GKVVVVTGASGPKGMGIEAARGCAEMGAAVAITYASRAQGAEENVK 65 Query: 191 QNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGG 241 + + + + D++ + + + G Sbjct: 66 ELEKTYGIKAKAYKCQVDSYESCEKLVKDVVADFGQIDAFIANAGATADSG 116 >3LYL-A nrPDB Length = 247 Score = 32.6 bits (73), Expect = 0.25, Method: Composition-based stats. Identities = 18/83 (21%), Positives = 33/83 (39%), Gaps = 9/83 (10%) Query: 153 LVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKI----VLQNGAHE---VFNHREVNY 205 LV GAS G+G + G ++GTA ++ + + + G V N ++ Sbjct: 9 LVTGASRGIGFEVAHALASKGATVVGTATSQASAEKFENSMKEKGFKARGLVLNISDIES 68 Query: 206 IDKIKKYVGEK--GIDIIIEMLA 226 I + + IDI++ Sbjct: 69 IQNFFAEIKAENLAIDILVNNAG 91 >3EZL-A nrPDB Length = 256 Score = 32.6 bits (73), Expect = 0.25, Method: Composition-based stats. Identities = 14/83 (16%), Positives = 27/83 (32%), Gaps = 10/83 (12%) Query: 154 VHGASGGVGLAACQIARAYGLKILGTAGTE-----EGQKIVLQNGAHEVF---NHREVNY 205 V G GG+G + CQ G +++ G + + G N + + Sbjct: 18 VTGGMGGIGTSICQRLHKDGFRVVAGCGPNSPRRVKWLEDQKALGFDFYASEGNVGDWDS 77 Query: 206 IDKIKKYVGE--KGIDIIIEMLA 226 + V ID+++ Sbjct: 78 TKQAFDKVKAEVGEIDVLVNNAG 100 >2Q2Q-A nrPDB Length = 255 Score = 32.6 bits (73), Expect = 0.25, Method: Composition-based stats. Identities = 17/85 (20%), Positives = 37/85 (43%), Gaps = 7/85 (8%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKIL--GTAGTEEGQKIVLQNGAHEVFNHREVNYI 206 G++ LV G++ G+GL Q+ G I+ G + ++G V + +++ + Sbjct: 4 GKTALVTGSTSGIGLGIAQVLARAGANIVLNGFGDPAPALAEIARHGVKAVHHPADLSDV 63 Query: 207 DKIKKYVGE-----KGIDIIIEMLA 226 +I+ G+DI++ Sbjct: 64 AQIEALFALAEREFGGVDILVNNAG 88 >6GBN-A nrPDB Length = 438 Score = 32.6 bits (73), Expect = 0.26, Method: Composition-based stats. Identities = 23/132 (17%), Positives = 41/132 (31%), Gaps = 15/132 (11%) Query: 139 ALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVF 198 ++ + V V V G VG + R G +++ T +G Sbjct: 208 SIRRATDVMMAGKVAVVAGYGDVGKGSAASLRGAGARVIVTEIDPICALQAAMDG----- 262 Query: 199 NHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRD 258 + D +K+ DI++ N N+ + +VIV + Sbjct: 263 -YEVKKMADAVKR------ADIVVTATGNKNIITGEHFKAMRDKVIVCNIG---HFDNEI 312 Query: 259 TMAKESSIIGVT 270 MA + G T Sbjct: 313 DMAWLNKTYGST 324 >5ITV-A nrPDB Length = 255 Score = 32.3 bits (72), Expect = 0.27, Method: Composition-based stats. Identities = 9/38 (23%), Positives = 17/38 (44%) Query: 150 ESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQK 187 ++VL+ G + G+G AA Q ++ E + Sbjct: 8 KTVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGE 45 >4AEC-A nrPDB Length = 430 Score = 32.3 bits (72), Expect = 0.29, Method: Composition-based stats. Identities = 17/73 (23%), Positives = 31/73 (42%), Gaps = 3/73 (4%) Query: 142 HSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGT---AGTEEGQKIVLQNGAHEVF 198 + G+SVLV SG G+ IA + G +++ T + + E + ++ GA V Sbjct: 167 QKGFISPGKSVLVEPTSGNTGIGLAFIAASRGYRLILTMPASMSMERRVLLKAFGAELVL 226 Query: 199 NHREVNYIDKIKK 211 ++K Sbjct: 227 TDPAKGMTGAVQK 239 >2NNL-D nrPDB Length = 337 Score = 32.3 bits (72), Expect = 0.30, Method: Composition-based stats. Identities = 12/43 (27%), Positives = 15/43 (34%) Query: 150 ESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQN 192 E+V V GASG +G G + T K V Sbjct: 6 ETVCVTGASGFIGSWLVMRLLERGYTVRATVRDPTNVKKVKHL 48 >1ZCJ-A nrPDB Length = 463 Score = 32.3 bits (72), Expect = 0.31, Method: Composition-based stats. Identities = 13/61 (21%), Positives = 22/61 (36%), Gaps = 3/61 (4%) Query: 133 YFTAYRALIHSACVKAGESVLVHGASGGVG-LAACQIARAYGLKILGTAGTEEGQKIVLQ 191 + T A +A + SV V G G +G A AR G+ ++ + + Sbjct: 21 WSTPSGASWKTASAQPVSSVGVLGL-GTMGRGIAISFARV-GISVVAVESDPKQLDAAKK 78 Query: 192 N 192 Sbjct: 79 I 79 >1OOE-A nrPDB Length = 236 Score = 32.3 bits (72), Expect = 0.34, Method: Composition-based stats. Identities = 12/85 (14%), Positives = 28/85 (32%), Gaps = 15/85 (17%) Query: 151 SVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVF--------NHRE 202 V+V+G G +G A + + G +L + Q A +E Sbjct: 5 KVIVYGGKGALGSAILEFFKKNGYTVLNIDLSANDQ-------ADSNILVDGNKNWTEQE 57 Query: 203 VNYIDKIKKYVGEKGIDIIIEMLAN 227 + +++ + +D + + Sbjct: 58 QSILEQTASSLQGSQVDGVFCVAGG 82 >1DIH-A nrPDB Length = 273 Score = 32.3 bits (72), Expect = 0.34, Method: Composition-based stats. Identities = 21/99 (21%), Positives = 36/99 (36%), Gaps = 1/99 (1%) Query: 152 VLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKK 211 V + GA G +G Q A A LG A EG ++ + + + Sbjct: 8 VAIAGAGGRMGRQLIQAALALEGVQLGAALEREGSSLLGSDAGELAGAGKTGVTVQSSLD 67 Query: 212 YVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRG 250 V + D+ I+ L+ G+ +V+G+ G Sbjct: 68 AVKDD-FDVFIDFTRPEGTLNHLAFCRQHGKGMVIGTTG 105 >3NJ4-A nrPDB Length = 435 Score = 31.9 bits (71), Expect = 0.39, Method: Composition-based stats. Identities = 10/45 (22%), Positives = 16/45 (35%) Query: 139 ALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTE 183 + + V V V G VG Q R +G +++ T Sbjct: 205 GIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDP 249 >4AVY-A nrPDB Length = 242 Score = 31.9 bits (71), Expect = 0.44, Method: Composition-based stats. Identities = 13/41 (31%), Positives = 21/41 (51%), Gaps = 2/41 (4%) Query: 139 ALIHSACVKAGESVLVHGASGGVG-LAACQIARAYGLKILG 178 ++ + AG+ VLV G S G+G A Q A G +++ Sbjct: 1 GMVFQHDIYAGQQVLVTGGSSGIGAAIAMQFAE-LGAEVVA 40 >4R1T-A nrPDB Length = 337 Score = 31.9 bits (71), Expect = 0.45, Method: Composition-based stats. Identities = 17/84 (20%), Positives = 29/84 (34%), Gaps = 3/84 (3%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEE--GQKIVLQN-GAHEVFNHREVNY 205 G+ V V GA G + +I G + GT + + + GA E + + Sbjct: 10 GQVVCVTGAGGFIASWLVKILLEKGYTVRGTVRNPDDPKNGHLRELEGAKERLTLCKADL 69 Query: 206 IDKIKKYVGEKGIDIIIEMLANVN 229 +D G D + + V Sbjct: 70 LDYQSLREAINGCDGVFHTASPVT 93 >5IJZ-A nrPDB Length = 447 Score = 31.9 bits (71), Expect = 0.46, Method: Composition-based stats. Identities = 27/158 (17%), Positives = 53/158 (33%), Gaps = 22/158 (13%) Query: 85 SAFKKGDRVFTSSTIS---GGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALI 141 GD I G Y A + V + L + G ++ T Y + Sbjct: 162 RDVPAGDIGVGGREIGYLFGHYRRMANQHESGVL-TGKGLTW--GGSLVRTEATGYGCVY 218 Query: 142 HSACV--KAGESV----LVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAH 195 + + GES+ ++ SG V A + A+ G ++G + + G Sbjct: 219 FVSEMIKAKGESISGQKIIVSGSGNVATYAIEKAQELGATVIGFSDSS---------GWV 269 Query: 196 EVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKD 233 N +V + +IK+ + + + + + D Sbjct: 270 HTPNGVDVAKLREIKEVRRAR-VSVYADEVEGATYHTD 306 >2O23-A nrPDB Length = 265 Score = 31.5 bits (70), Expect = 0.47, Method: Composition-based stats. Identities = 18/114 (15%), Positives = 37/114 (32%), Gaps = 7/114 (6%) Query: 153 LVHGASGGVGLAACQIARAYGLKILGTAGTEE-GQKIVLQNGAHEVFNHRE---VNYIDK 208 ++ G + G+GLA + G + G+ + G + VF + + Sbjct: 16 VITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQT 75 Query: 209 IKKYVGEK--GIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTM 260 K +D+ + SK L G + + +++N T Sbjct: 76 ALALAKGKFGRVDVAVNCAGIAVASKT-YNLKKGQTHTLEDFQRVLDVNLMGTF 128 >2BHS-A nrPDB Length = 303 Score = 31.5 bits (70), Expect = 0.47, Method: Composition-based stats. Identities = 15/66 (22%), Positives = 28/66 (42%), Gaps = 4/66 (6%) Query: 142 HSACVKAGESVLVHGASGGVGLAACQIARAYGLK---ILGTAGTEEGQKIVLQNGAHEVF 198 +K G+ VL+ SG G+A IA G + ++ ++E + + GA + Sbjct: 54 KRGEIKPGD-VLIEATSGNTGIALAMIAALKGYRMKLLMPDNMSQERRAAMRAYGAELIL 112 Query: 199 NHREVN 204 +E Sbjct: 113 VTKEQG 118 >2JC3-A nrPDB Length = 303 Score = 31.5 bits (70), Expect = 0.48, Method: Composition-based stats. Identities = 15/66 (22%), Positives = 28/66 (42%), Gaps = 4/66 (6%) Query: 142 HSACVKAGESVLVHGASGGVGLAACQIARAYGLK---ILGTAGTEEGQKIVLQNGAHEVF 198 +K G+ VL+ SG G+A IA G + ++ ++E + + GA + Sbjct: 54 KRGEIKPGD-VLIEATSGNTGIALAMIAALKGYRMKLLMPDNMSQERRAAMRAYGAELIL 112 Query: 199 NHREVN 204 +E Sbjct: 113 VTKEQG 118 >1AE1-A nrPDB Length = 273 Score = 31.5 bits (70), Expect = 0.49, Method: Composition-based stats. Identities = 15/88 (17%), Positives = 33/88 (37%), Gaps = 10/88 (11%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFN--------- 199 G + LV G S G+G A + G ++ + E+ L+ + N Sbjct: 21 GTTALVTGGSKGIGYAIVEELAGLGARVYTCSRNEKELDECLEIWREKGLNVEGSVCDLL 80 Query: 200 -HREVNYIDKIKKYVGEKGIDIIIEMLA 226 E + + + +V + ++I++ Sbjct: 81 SRTERDKLMQTVAHVFDGKLNILVNNAG 108 >3OND-A nrPDB Length = 488 Score = 31.5 bits (70), Expect = 0.49, Method: Composition-based stats. Identities = 9/45 (20%), Positives = 15/45 (33%) Query: 139 ALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTE 183 L+ + V V V G VG + G +++ T Sbjct: 254 GLMRATDVMIAGKVAVVAGYGDVGKGCAAALKQAGARVIVTEIDP 298 >3T4P-A nrPDB Length = 334 Score = 31.5 bits (70), Expect = 0.50, Method: Composition-based stats. Identities = 13/76 (17%), Positives = 31/76 (40%), Gaps = 3/76 (3%) Query: 137 YRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGT---AGTEEGQKIVLQNG 193 Y + G+S++V +SG G++ + G K++ T + + E + ++ G Sbjct: 59 YDKAEKEGKLIPGKSIVVESSSGNTGVSLAHLGAIRGYKVIITMPESMSLERRCLLRIFG 118 Query: 194 AHEVFNHREVNYIDKI 209 A + + + Sbjct: 119 AEVILTPAALGMKGAV 134 >3ZWA-A nrPDB Length = 742 Score = 31.5 bits (70), Expect = 0.51, Method: Composition-based stats. Identities = 13/61 (21%), Positives = 22/61 (36%), Gaps = 3/61 (4%) Query: 133 YFTAYRALIHSACVKAGESVLVHGASGGVG-LAACQIARAYGLKILGTAGTEEGQKIVLQ 191 + T A +A + SV V G G +G A AR G+ ++ + + Sbjct: 300 WSTPSGASWKTASAQPVSSVGVLGL-GTMGRGIAISFARV-GISVVAVESDPKQLDAAKK 357 Query: 192 N 192 Sbjct: 358 I 358 >2VHY-A nrPDB Length = 377 Score = 31.5 bits (70), Expect = 0.53, Method: Composition-based stats. Identities = 13/83 (15%), Positives = 25/83 (30%), Gaps = 12/83 (14%) Query: 117 LPEKLDFKQGAAIGIPYFTAYRALIHSAC----------VKAGESVLVHGASGGVGLAAC 166 LP + A AY + V+ + V++ +G G A Sbjct: 127 LPLLAPMSEVAGRLAAQVGAYHLMRTQGGRGVLMGGVPGVEPADVVVI--GAGTAGYNAA 184 Query: 167 QIARAYGLKILGTAGTEEGQKIV 189 +IA G + + + + Sbjct: 185 RIANGMGATVTVLDINIDKLRQL 207 >4K2X-A nrPDB Length = 523 Score = 31.5 bits (70), Expect = 0.54, Method: Composition-based stats. Identities = 10/44 (22%), Positives = 13/44 (29%) Query: 153 LVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHE 196 +V +G GL R G + L E G H Sbjct: 25 VVIAGAGPTGLMLACELRLAGARTLVLERLAEPVDFSKALGVHA 68 >6GME-A nrPDB Length = 201 Score = 31.5 bits (70), Expect = 0.56, Method: Composition-based stats. Identities = 9/31 (29%), Positives = 13/31 (41%) Query: 179 TAGTEEGQKIVLQNGAHEVFNHREVNYIDKI 209 EEG++ GA N E +D+I Sbjct: 62 VDVREEGKENAFSLGATLWINSEEFEDLDEI 92 >1EZ1-A nrPDB Length = 392 Score = 31.5 bits (70), Expect = 0.58, Method: Composition-based stats. Identities = 27/202 (13%), Positives = 69/202 (34%), Gaps = 21/202 (10%) Query: 139 ALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKI--VLQNGAHE 196 + ++ + ++ SG +G + G++++ + + + Sbjct: 1 MTLLGTALRPAATRVMLLGSGELGKEVAIECQRLGVEVIAVDRYADAPAMHVAHR---SH 57 Query: 197 VFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEIN- 255 V N + + + ++ + I+ + + + L G V+ + +N Sbjct: 58 VINMLDGDALRRVVELEKP---HYIVPEIEAIATDMLIQLEEEGLNVVPCARATKLTMNR 114 Query: 256 --PRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYP-------LE 306 R A+E + T + E + A+ +KPV+ S E Sbjct: 115 EGIRRLAAEELQLPTSTYRFADSESL--FREAVADIGYPCIVKPVMSSSGKGQTFIRSAE 172 Query: 307 KVAEAHENIIH-GSGATGKMIL 327 ++A+A + G G++I+ Sbjct: 173 QLAQAWKYAQQGGRAGAGRVIV 194 >2ZJ1-A nrPDB Length = 495 Score = 31.5 bits (70), Expect = 0.59, Method: Composition-based stats. Identities = 17/77 (22%), Positives = 29/77 (37%), Gaps = 2/77 (2%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDK 208 G+ VL+ G G VG + + G ++ T + G V + D Sbjct: 275 GKKVLICG-YGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADI 333 Query: 209 IKKYVGEKGIDIIIEML 225 + G K I I++E + Sbjct: 334 VVTATGNKDI-IMLEHI 349 >5WQO-A nrPDB Length = 234 Score = 31.1 bits (69), Expect = 0.60, Method: Composition-based stats. Identities = 19/84 (22%), Positives = 36/84 (42%), Gaps = 7/84 (8%) Query: 150 ESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEG----QKIVLQNG---AHEVFNHRE 202 +VL+ GAS G+GL G ++ A +G Q + + G + + Sbjct: 7 HNVLIVGASRGIGLGLADAFLQRGAQVFAVARRPQGSPGLQALAERAGERLQAVTGDLNQ 66 Query: 203 VNYIDKIKKYVGEKGIDIIIEMLA 226 + ++I + +GE+ ID +I Sbjct: 67 HDCAERIGEMLGERRIDRLIVNAG 90 >2C20-A nrPDB Length = 330 Score = 31.1 bits (69), Expect = 0.66, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 21/44 (47%) Query: 151 SVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGA 194 S+L+ G +G +G A + GL ++ + G + + GA Sbjct: 3 SILICGGAGYIGSHAVKKLVDEGLSVVVVDNLQTGHEDAITEGA 46 >4DI9-A nrPDB Length = 303 Score = 31.1 bits (69), Expect = 0.71, Method: Composition-based stats. Identities = 6/57 (10%), Positives = 27/57 (47%), Gaps = 1/57 (1%) Query: 180 AGTEEGQKIVLQNGA-HEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLS 235 A ++ ++ + A V + E + +++++ ++ + I+I+ + ++ + Sbjct: 135 APKDKFLEVAGRLPAGWHVVIYFEADILEELRPFMDAIPVPIVIDHMGRPDVRQGPD 191 >4PVC-A nrPDB Length = 342 Score = 31.1 bits (69), Expect = 0.75, Method: Composition-based stats. Identities = 13/78 (16%), Positives = 29/78 (37%), Gaps = 5/78 (6%) Query: 151 SVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIK 210 SV V GA+G + + K++G+A ++E + + E F + ++ + Sbjct: 2 SVFVSGANGFIAQHIVDLLLKEDYKVIGSARSQEKAENL-----TEAFGNNPKFSMEVVP 56 Query: 211 KYVGEKGIDIIIEMLANV 228 D + + Sbjct: 57 DISKLDAFDHVFQKHGKD 74 >4CQM-B nrPDB Length = 244 Score = 31.1 bits (69), Expect = 0.76, Method: Composition-based stats. Identities = 13/83 (15%), Positives = 28/83 (33%), Gaps = 6/83 (7%) Query: 150 ESVLVHGASGGVGLAACQIARAYGLKILGTAGTEE-GQKIVLQNGAHE----VFNHREVN 204 + V G S G+G A Q+ G ++ A E + G +E + Sbjct: 10 KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHD 69 Query: 205 YIDKIKKYVGEKG-IDIIIEMLA 226 + ++ G ++ ++ Sbjct: 70 VQNTFEELEKHLGRVNFLVNAAG 92 >5VMT-A nrPDB Length = 342 Score = 30.7 bits (68), Expect = 0.81, Method: Composition-based stats. Identities = 31/176 (17%), Positives = 64/176 (36%), Gaps = 24/176 (13%) Query: 151 SVLVHGASGGVGLAAC-QIARAYGLKILGT---------------AGTEEGQKIVLQNGA 194 V ++G G +G A QI +A+G+++ T+ + + Sbjct: 12 KVAINGF-GRIGRLALRQIEKAHGIEVAAVNDLTPAEMLLHLFKYDSTQGRFQGTAELKD 70 Query: 195 HE-VFNHREVNYIDKIKKYV---GEKGIDIIIEMLA-NVNLSKDLSLLSHGGRVIVVGSR 249 V N RE+ GE G+D+++E N +K + + G R +V+ + Sbjct: 71 DAIVVNGREIKVFANPNPEELPWGELGVDVVLECTGFFTNKTKAEAHIRAGARKVVISAP 130 Query: 250 GTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQA--GMEIGWLKPVIGSQY 303 G ++ + + G S A + A E G ++ ++ + + Sbjct: 131 GGNDVKTVVYGVNQDILDGSETVISAASCTTNCLAPMAAVLQKEFGVVEGLMTTIH 186 >3EVZ-A nrPDB Length = 230 Score = 30.7 bits (68), Expect = 0.84, Method: Composition-based stats. Identities = 30/177 (16%), Positives = 54/177 (30%), Gaps = 39/177 (22%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDK 208 G V + +G + A + + K+ T EE + +N N R V Sbjct: 55 GGEVALEIGTGHTAMMALMAEKFFNCKVTATEVDEEFFEYARRNIERNNSNVRLVKSNGG 114 Query: 209 IKKYVGEKGIDIII-----------------EMLAN---------VNLSKDLSLLSHGGR 242 I K V E D+I E + L + L+ GG+ Sbjct: 115 IIKGVVEGTFDVIFSAPPYYDKPLGRVLTEREAIGGGKYGEEFSVKLLEEAFDHLNPGGK 174 Query: 243 VIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKE------EFQQYAAALQAGMEIG 293 V + + ++ + G+ L S K+ +++ G+ G Sbjct: 175 VALY-------LPDKEKLLNVIKERGIKLGYSVKDIKFKVGTRWRHSLIFFKGISEG 224 >5EES-A nrPDB Length = 247 Score = 30.7 bits (68), Expect = 0.86, Method: Composition-based stats. Identities = 20/125 (16%), Positives = 41/125 (32%), Gaps = 25/125 (20%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDK 208 G V V GA G VG I+ + ++V + G + Sbjct: 1 GIKVGVLGAKGRVGQ-----------TIVAAVNESDDLELVAEIGVDDDL---------- 39 Query: 209 IKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRG--TIEINPRDTMAKESSI 266 + + G +++++ + +L + G VVG+ G + + Sbjct: 40 --SLLVDNGAEVVVDFTTPNAVMGNLEFCINNGISAVVGTTGFDDARLEQVRDWLEGKDN 97 Query: 267 IGVTL 271 +GV + Sbjct: 98 VGVLI 102 >2YVG-A nrPDB Length = 408 Score = 30.7 bits (68), Expect = 0.93, Method: Composition-based stats. Identities = 24/107 (22%), Positives = 40/107 (37%), Gaps = 13/107 (12%) Query: 118 PEKLDFKQGAAIGIPYF-TAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKI 176 P L QGA + + T A A ++ +L+ G G +GL AR G+ + Sbjct: 113 PRALPTLQGATMPVHTLRTLEDARRIQAGLRPQSRLLIVGG-GVIGLELAATARTAGVHV 171 Query: 177 LGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIE 223 E Q ++ A D + +Y +G+D+ E Sbjct: 172 SLV----ETQPRLMSRAAPATL-------ADFVARYHAAQGVDLRFE 207 >1GEE-A nrPDB Length = 261 Score = 30.7 bits (68), Expect = 0.96, Method: Composition-based stats. Identities = 31/181 (17%), Positives = 62/181 (34%), Gaps = 19/181 (10%) Query: 148 AGESVLVHGASGGVG-LAACQIARAYGLKILGTAGTEEG-----QKIVLQNG-------A 194 G+ V++ G+S G+G A + A K++ ++E + + + G Sbjct: 6 EGKVVVITGSSTGLGKSMAIRFATEK-AKVVVNYRSKEDEANSVLEEIKKVGGEAIAVKG 64 Query: 195 HEVFNHREVNYIDKIKKYVGEKGIDIIIEMLA-NVNLSKDLSLLSHGGRVIVVGSRGTIE 253 +N + K G+ +D++I +S LS +VI G Sbjct: 65 DVTVESDVINLVQSAIKEFGK--LDVMINNAGLENPVSSHEMSLSDWNKVIDTNLTGAFL 122 Query: 254 INPRDT-MAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAH 312 + E+ I G + S+ E + + G +K ++ LE + Sbjct: 123 GSREAIKYFVENDIKGTVINMSSVHEKIPWPLFVHYAASKGGMK-LMTETLALEYAPKGI 181 Query: 313 E 313 Sbjct: 182 R 182 >2EKL-A nrPDB Length = 313 Score = 30.7 bits (68), Expect = 0.98, Method: Composition-based stats. Identities = 13/50 (26%), Positives = 24/50 (48%), Gaps = 2/50 (4%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEV 197 AG+++ + G G +G IA A G+K+L + ++ + A V Sbjct: 141 AGKTIGIVGF-GRIGTKVGIIANAMGMKVLAYDILD-IREKAEKINAKAV 188 >2RIR-A nrPDB Length = 300 Score = 30.7 bits (68), Expect = 1.00, Method: Composition-based stats. Identities = 30/129 (23%), Positives = 43/129 (33%), Gaps = 9/129 (6%) Query: 73 VAGVIEAVGDNASAFKKGDRV-------FTSSTISGGYAEYALAADH-TVYKLPEKLDFK 124 GV+ V N K D + S IS Y E A + KL E+ D Sbjct: 73 GEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSGISNAYLENIAAQAKRKLVKLFERDDIA 132 Query: 125 QGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEE 184 +I T A+ H+ G V V G G G+ + A G + A + Sbjct: 133 IYNSIPTVEGTIMLAIQHTDYTIHGSQVAVLGL-GRTGMTIARTFAALGANVKVGARSSA 191 Query: 185 GQKIVLQNG 193 + + G Sbjct: 192 HLARITEMG 200 >6GCS-E nrPDB Length = 375 Score = 30.7 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 18/92 (19%), Positives = 43/92 (46%), Gaps = 6/92 (6%) Query: 147 KAGESVLVHGASGGVGLA-ACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNY 205 + G + V GA+G +G ++A+ G ++ E ++ + G V N E++ Sbjct: 51 RTGYTATVFGANGFLGSYLTAKLAKH-GTTVVVPYREEMAKRHLKVTGDLGVVNFLEMDL 109 Query: 206 --IDKIKKYVGEKGIDIIIEMLANVNLSKDLS 235 ++ I + V + DI++ ++ +K+ + Sbjct: 110 RNLESIDEAV--RHSDIVVNLIGREYETKNFN 139 >2ISQ-A nrPDB Length = 320 Score = 30.3 bits (67), Expect = 1.0, Method: Composition-based stats. Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 7/62 (11%) Query: 142 HSACVKAGESVLV--HGASGGVGLAACQIARAYGLKILGT---AGTEEGQKIVLQNGAHE 196 +K GESVL+ + GVGLA A+ G K++ T + + E + I+L G Sbjct: 57 KKGLIKPGESVLIEPTSGNTGVGLAFTAAAK--GYKLIITMPASMSTERRIILLAFGVEL 114 Query: 197 VF 198 V Sbjct: 115 VL 116 >5U9P-A nrPDB Length = 265 Score = 30.3 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 17/87 (19%), Positives = 28/87 (32%), Gaps = 9/87 (10%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQ------NGAHE-VFNHR 201 G L+ G+ G+GL + G I+ EE + + A VF+ Sbjct: 20 GRRALITGSGRGIGLTLARGLAEAGAAIVINDRNEEKAATLARRFRDEGFAADHAVFDVA 79 Query: 202 EVNYIDKIKKYVGE--KGIDIIIEMLA 226 E + IDI++ Sbjct: 80 EHAQVRAAIDEFEARVGAIDILVNNAG 106 >3RKU-A nrPDB Length = 287 Score = 30.3 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 13/45 (28%), Positives = 24/45 (53%), Gaps = 3/45 (6%) Query: 150 ESVLVHGASGGVGLA-ACQIARAYG--LKILGTAGTEEGQKIVLQ 191 ++VL+ GAS G+G A A + A +K++ A E + + + Sbjct: 34 KTVLITGASAGIGKATALEYLEASNGDMKLILAARRLEKLEELKK 78 >1E3W-A nrPDB Length = 261 Score = 30.3 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 18/115 (15%), Positives = 37/115 (32%), Gaps = 13/115 (11%) Query: 153 LVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKI-VLQNGAHEVFNHREVNYIDKIKK 211 ++ G + G+GL+ + G + + + G + +F V +++ Sbjct: 14 VITGGASGLGLSTAKRLVGQGATAVLLDVPNSEGETEAKKLGGNCIFAPANVTSEKEVQA 73 Query: 212 YVGE-----KGIDIIIEMLANVNLSKD-------LSLLSHGGRVIVVGSRGTIEI 254 + ID+ + K + L RVI V GT + Sbjct: 74 ALTLAKEKFGRIDVAVNCAGIAVAIKTYHEKKNQVHTLEDFQRVINVNLIGTFNV 128 >1DXY-A nrPDB Length = 333 Score = 30.3 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 8/38 (21%), Positives = 18/38 (47%), Gaps = 1/38 (2%) Query: 150 ESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQK 187 ++V V G +G +G A ++ + +G K++ Sbjct: 146 QTVGVMG-TGHIGQVAIKLFKGFGAKVIAYDPYPMKGD 182 >6CU3-A nrPDB Length = 336 Score = 30.3 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 10/41 (24%), Positives = 18/41 (43%) Query: 188 IVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANV 228 + GA V + IDK ++ V + G +IE++ Sbjct: 68 FAAKAGAKRVIGIDMSDIIDKARQIVSDNGYSHVIELIKGK 108 >5EKU-A nrPDB Length = 390 Score = 30.3 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 15/48 (31%), Positives = 22/48 (45%), Gaps = 4/48 (8%) Query: 145 CVKAGESVLVHGASGGVGLAACQIARAYGLK-ILGTAGTEEGQKIVLQ 191 V VL GA G GL + A+ G K ++ G+EE K+ + Sbjct: 92 HVTPETGVLEIGA--GSGLLSLMAAK-LGAKWVVAVEGSEELAKLARE 136 >4M36-A nrPDB Length = 343 Score = 30.3 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 15/48 (31%), Positives = 22/48 (45%), Gaps = 4/48 (8%) Query: 145 CVKAGESVLVHGASGGVGLAACQIARAYGLK-ILGTAGTEEGQKIVLQ 191 V VL GA G GL + A+ G K ++ G+EE K+ + Sbjct: 57 HVTPETGVLEIGA--GSGLLSLMAAK-LGAKWVVAVEGSEELAKLARE 101 >1YFM-A nrPDB Length = 488 Score = 30.3 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 6/37 (16%), Positives = 15/37 (40%) Query: 51 ETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAF 87 + ++ G + P T G + +G ++ V + Sbjct: 204 DHIVKIGRTHLQDATPLTLGQEFSGYVQQVENGIQRV 240 >5BZA-A nrPDB Length = 467 Score = 30.3 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 11/79 (13%), Positives = 28/79 (35%), Gaps = 2/79 (2%) Query: 227 NVNLSKDLSLLSHGGRVIVVGSRGT--IEINPRDTMAKESSIIGVTLFSSTKEEFQQYAA 284 N + + G +I G + ++ + +++ I + + E +Y Sbjct: 17 NEEAREVIQKYRPAGVLIYPGVLSKEYLFLDFMNFLSRNGRFIVSSDHEGGQLEVLKYVP 76 Query: 285 ALQAGMEIGWLKPVIGSQY 303 + + G + PV +Y Sbjct: 77 SFPGNLAAGKVDPVFTGRY 95 >4LMB-A nrPDB Length = 322 Score = 30.0 bits (66), Expect = 1.3, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 26/65 (40%), Gaps = 3/65 (4%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGT---AGTEEGQKIVLQNGAHEVFNHREVN 204 +++LV SG G+A +A A G +++ T + E + ++ GA Sbjct: 72 PDKTILVEPTSGNTGIALAMVAAAKGYRLVLTMPETMSLERRAMLKAYGAQLELTPGSQG 131 Query: 205 YIDKI 209 I Sbjct: 132 MEGAI 136 >2UVD-A nrPDB Length = 246 Score = 30.0 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 19/88 (21%), Positives = 38/88 (43%), Gaps = 10/88 (11%) Query: 149 GESVLVHGASGGVG-LAACQIARAYGLKILGTAGTEEG----QKIVLQNGAHEVFNHRE- 202 G+ LV GAS G+G A +A+ ++ AG E+ + + G+ + + Sbjct: 4 GKVALVTGASRGIGRAIAIDLAKQGANVVVNYAGNEQKANEVVDEIKKLGSDAIAVRADV 63 Query: 203 ---VNYIDKIKKYVGEKG-IDIIIEMLA 226 + + +K+ V G +DI++ Sbjct: 64 ANAEDVTNMVKQTVDVFGQVDILVNNAG 91 >4FHN-X nrPDB Length = 450 Score = 30.0 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 29/213 (13%), Positives = 65/213 (30%), Gaps = 31/213 (14%) Query: 119 EKLDFKQGAAIGIPYFTAYR-------ALIHSACVKAGESVLVHGASGGVGLAACQIARA 171 + L F G ++ P T Y L G V V G SG V A + A Sbjct: 200 KGLSF--GGSLIRPEATGYGLVYFTEAMLKRHGMGFEGMRVSVSG-SGNVAQYAIEKAME 256 Query: 172 YGLKILGTAGT-----------EEGQKIVLQNGAH---EVFNH-REVNYIDKIKKYVGEK 216 +G +++ + + +E +++ + V ++ +E + + Sbjct: 257 FGARVITASDSSGTVVDESGFTKEKLARLIEIKSSRDGRVADYAKEFGLVYLEGQQPWSV 316 Query: 217 GIDIIIEMLANVNL--SKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSII----GVT 270 +DI + L L+++G + + G+ I + + + Sbjct: 317 PVDIALPCATQNELDVDAAHQLIANGVKAVAEGANMPTTIEATELFQQAGVLFAPGKAAN 376 Query: 271 LFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQY 303 + A + G + + + Sbjct: 377 AGGVATSGLEMAQNAARLGWKAEKVDARLHHIM 409 >2GLX-A nrPDB Length = 332 Score = 30.0 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 18/135 (13%), Positives = 46/135 (34%), Gaps = 7/135 (5%) Query: 170 RAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVN 229 RA G +++ T + GA + + +++ VG+ +D + N Sbjct: 21 RATGGEVVSMMSTSA------ERGAAYATENGIGKSVTSVEELVGDPDVDAVYVSTTNEL 74 Query: 230 LSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAG 289 + G+ ++ + + M + GV L ++ A++ Sbjct: 75 HREQTLAAIRAGKHVLCEKPLAMTLEDAREMVVAAREAGVVLGTNHHLRNAAAHRAMRDA 134 Query: 290 MEIGWL-KPVIGSQY 303 + G + +P+ + Sbjct: 135 IAEGRIGRPIAARVF 149 >2C07-A nrPDB Length = 285 Score = 30.0 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 17/86 (19%), Positives = 34/86 (39%), Gaps = 15/86 (17%) Query: 153 LVHGASGGVG-LAACQIARAYGLKILGTAGTEEG----QKIVLQNG------AHEVFNHR 201 LV GA G+G A +A++ ++ + T++ + G A +V + Sbjct: 48 LVTGAGRGIGREIAKMLAKSV-SHVICISRTQKSCDSVVDEIKSFGYESSGYAGDV--SK 104 Query: 202 EVNYIDKIKKY-VGEKGIDIIIEMLA 226 + + I K K +DI++ Sbjct: 105 KEEISEVINKILTEHKNVDILVNNAG 130 >5TEN-A nrPDB Length = 269 Score = 30.0 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 23/102 (22%), Positives = 46/102 (45%), Gaps = 7/102 (6%) Query: 152 VLVHGASGGVGLAACQIARAYG-LKILGTAGTEEGQKIVLQNGAHEVFNHREVNYI--DK 208 + V GA+G +G + A K+ + E + + G E+ + + + D Sbjct: 4 IAVAGAAGRMGRNLVKAAHHNPVAKVAAGSERPESSLVGVDLG--ELCGEGKFDVVVCDD 61 Query: 209 IKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRG 250 + K + + D+II+ A + +L+L G+ IV+G+ G Sbjct: 62 LAKQIDQ--FDVIIDFTAPASTLNNLALCQQYGKSIVIGTTG 101 >4X3Q-A nrPDB Length = 355 Score = 30.0 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 20/104 (19%), Positives = 33/104 (31%), Gaps = 9/104 (8%) Query: 154 VHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYV 213 V GG + A +ARA+ + ++ + A R + I Sbjct: 174 VLDVGGGDAVNAVALARAHPSLRVTVLDRPGALEVARKTIAEAGLEERVRTHAADIFTDS 233 Query: 214 GEKGIDIIIEMLANVNLS---------KDLSLLSHGGRVIVVGS 248 G D ++ V S K + GGRV+V + Sbjct: 234 YPAGHDCVLFAHQLVIWSPEQNLTLLRKAYDAVEPGGRVLVFNA 277 >3HG7-A nrPDB Length = 324 Score = 30.0 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 11/50 (22%), Positives = 25/50 (50%), Gaps = 6/50 (12%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVF 198 G ++L+ G +G +G + +G+K+LG + + + G +V+ Sbjct: 140 GRTLLILG-TGSIGQHIAHTGKHFGMKVLGVSRSGRERA-----GFDQVY 183 >3X43-A nrPDB Length = 332 Score = 30.0 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 16/59 (27%), Positives = 28/59 (47%), Gaps = 4/59 (6%) Query: 143 SACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAG---TEEGQKIVLQNGAHEVF 198 +K G+++ V SG VG+A +A A G + + G + E +K++ G V Sbjct: 57 KGLLKPGDTI-VECTSGNVGIALAMVAAARGYRFVAVMGDTYSVERRKLIRAYGGKLVL 114 >2B4Q-A nrPDB Length = 276 Score = 30.0 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 13/48 (27%), Positives = 17/48 (35%), Gaps = 1/48 (2%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEG-QKIVLQNGA 194 AG LV G S G+G Q G ++ A E + A Sbjct: 28 AGRIALVTGGSRGIGQMIAQGLLEAGARVFICARDAEACADTATRLSA 75 >2X36-A nrPDB Length = 207 Score = 30.0 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 22/120 (18%), Positives = 37/120 (30%), Gaps = 16/120 (13%) Query: 104 AEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGL 163 A L H +PE K G + G TA +L V+ +++ + G G Sbjct: 79 ANDYLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLAMGRPVR--QNLAMTGEVSLTG- 135 Query: 164 AACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHRE--VNYIDKIKKYVGEKGIDII 221 KIL G +E + G + E ++ D + + Sbjct: 136 -----------KILPVGGIKEKTIAAKRAGVTCIVLPAENKKDFYDLAAFITEGLEVHFV 184 >5UJU-A nrPDB Length = 576 Score = 29.6 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 9/72 (12%), Positives = 23/72 (31%), Gaps = 5/72 (6%) Query: 176 ILGTAGTEEGQKIVLQNGAHEV-----FNHREVNYIDKIKKYVGEKGIDIIIEMLANVNL 230 ++ T T + + + A + ID + G+ + I + V + Sbjct: 463 VIATDSTAQSLDLAGEIAAEHGALTLSVYSTADDVIDAAHEAAVRGGVALSINLTGGVFV 522 Query: 231 SKDLSLLSHGGR 242 ++ + G Sbjct: 523 NQSAAFSDFHGT 534 >4GGP-A nrPDB Length = 401 Score = 29.6 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 26/127 (20%), Positives = 49/127 (38%), Gaps = 7/127 (5%) Query: 143 SACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHRE 202 A KA ++VLV G S G GL A +I A+G + E + G +N+ Sbjct: 44 KAGAKAPKNVLVLGCSNGYGL-ASRITAAFGYGAATIGVSFEKAGSETKYGTPGWYNNLA 102 Query: 203 VNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGG---RVIVVGSRGTIEINPRDT 259 + + K G + I + ++ ++ + G +IV + +P Sbjct: 103 FD---EAAKREGLYSVTIDGDAFSDEIKAQVIEEAKKKGIKFDLIVYSLASPVRTDPDTG 159 Query: 260 MAKESSI 266 + +S + Sbjct: 160 IMHKSVL 166 >1HE4-A nrPDB Length = 206 Score = 29.6 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 20/99 (20%), Positives = 33/99 (33%), Gaps = 4/99 (4%) Query: 150 ESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKI 209 + + + GA+G GL A G ++ AH V + + Sbjct: 4 KKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVV----GDVLQAA 59 Query: 210 KKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGS 248 G D +I +L N +++S G R IV Sbjct: 60 DVDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAM 98 >5JFC-L nrPDB Length = 474 Score = 29.6 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 26/151 (17%), Positives = 49/151 (32%), Gaps = 12/151 (7%) Query: 173 GLKILGTAGTEEGQKIVLQNGAHEVFNH--REVNYIDKIKKYVGEKGIDIIIEMLANVNL 230 G ++G G + + A H + +++IK G + I L Sbjct: 109 GACVVGKVGDPINIGKLERFVADYAREHGIDDELLLEEIKGIKR-NGKKVAIIGAGPAGL 167 Query: 231 SKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGM 290 + L G V + + I G+ F KE ++ L+ Sbjct: 168 TCAADLAKMGYEVTIYEA---------LHQPGGVLIYGIPEFRLPKEIVKKELENLRRLG 218 Query: 291 EIGWLKPVIGSQYPLEKVAEAHENIIHGSGA 321 ++G E++ E ++ I G+GA Sbjct: 219 VKIETNVLVGKTITFEELREEYDAIFIGTGA 249 >5TC4-A nrPDB Length = 316 Score = 29.6 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 22/126 (17%), Positives = 41/126 (32%), Gaps = 18/126 (14%) Query: 123 FKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGT 182 Q + + + + + + G++V+V G S VG+ + G Sbjct: 133 LDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAH------- 185 Query: 183 EEGQKIVLQNGAHEVFN-HREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGG 241 + G +++KK+ DI+I NL ++ G Sbjct: 186 -------ERPGGDATVTISHRYTPKEQLKKHTILA--DIVISAAGIPNLITA-DMIKEGA 235 Query: 242 RVIVVG 247 VI VG Sbjct: 236 AVIDVG 241 >1QO8-A nrPDB Length = 566 Score = 29.6 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 10/41 (24%), Positives = 14/41 (34%), Gaps = 1/41 (2%) Query: 143 SACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTE 183 +A VLV GA G A A+ G ++ Sbjct: 115 AAGPSETTQVLVVGAGSA-GFNASLAAKKAGANVILVDKAP 154 >2PK3-A nrPDB Length = 321 Score = 29.6 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 35/182 (19%), Positives = 67/182 (36%), Gaps = 22/182 (12%) Query: 138 RALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTA-----GTEEGQKIVLQN 192 + ++ V AS VG+ A Q +AYG+ I+ T G + V Q+ Sbjct: 138 SPVSEENQLRPMSPYGVSKAS--VGMLARQYVKAYGMDIIHTRTFNHIGPGQSLGFVTQD 195 Query: 193 GAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGR----VIVVGS 248 A ++ + E+ + I K ++ + + ++ + LLS G+ V Sbjct: 196 FAKQIVDI-EMEKQEPIIKV---GNLEAVRDFTDVRDIVQAYWLLSQYGKTGDVYNVCSG 251 Query: 249 RGTIEINPRDTMAKESSIIGVTLFSST---KEEFQQYAAALQAGMEIGWLKPVIGSQYPL 305 GT + D + +++ T + E + + + KP + PL Sbjct: 252 IGTRIQDVLDLLLAMANVKIDTELNPLQLRPSEVPTLIGSNKRLKDSTGWKP----RIPL 307 Query: 306 EK 307 EK Sbjct: 308 EK 309 >3N58-A nrPDB Length = 464 Score = 29.6 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 17/127 (13%), Positives = 36/127 (28%), Gaps = 13/127 (10%) Query: 139 ALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVF 198 + V V V G VG + Q G ++ T +G V Sbjct: 236 GIRRGTDVMMAGKVAVVCGYGDVGKGSAQSLAGAGARVKVTEVDPICALQAAMDGFEVV- 294 Query: 199 NHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRD 258 ++ DI++ N ++ + + + +VG+ G + + Sbjct: 295 ---TLDDAAST--------ADIVVTTTGNKDV-ITIDHMRKMKDMCIVGNIGHFDNEIQV 342 Query: 259 TMAKESS 265 + Sbjct: 343 AALRNLK 349 >1V9L-A nrPDB Length = 421 Score = 29.6 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 19/108 (17%), Positives = 31/108 (28%), Gaps = 16/108 (14%) Query: 89 KGDRVFTSSTISGGYA--------EYALAADHTV----YKLPEKL---DFKQGAAIGIPY 133 GD V + G A EY+ + V P +L ++ A Sbjct: 135 IGDVVDIPAPDVGTNAQIMAWMVDEYSKIKGYNVPGVFTSKPPELWGNPVREYATGFGVA 194 Query: 134 FTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAG 181 G++V + G G VG G K++ + Sbjct: 195 VATREMAKKLWGGIEGKTVAIQG-MGNVGRWTAYWLEKMGAKVIAVSD 241 >4Z9Y-A nrPDB Length = 253 Score = 29.6 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 18/89 (20%), Positives = 32/89 (35%), Gaps = 13/89 (14%) Query: 148 AGESVLVHGASGGVGL-AACQIARAYGLKILGT--AGTEEGQKIVLQNG-------AHEV 197 G+ L+ G G+G A +A+A G I+G ++ + V G A Sbjct: 9 QGKVALITGCDTGLGQGMAIGLAQA-GCDIVGVNIVEPKDTIEKVTALGRRFLSLTADMS 67 Query: 198 FNHREVNYIDKIKKYVGEKGIDIIIEMLA 226 ++K G +DI++ Sbjct: 68 NVSGHAELVEKAVAEFG--HVDILVNNAG 94 >2PNF-A nrPDB Length = 248 Score = 29.6 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 22/89 (24%), Positives = 39/89 (43%), Gaps = 10/89 (11%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEG-----QKIVLQNG--AHEV-FN 199 G+ LV G++ G+G A + + G ++ T + E ++I + G AH V N Sbjct: 6 QGKVSLVTGSTRGIGRAIAEKLASAGSTVIITGTSGERAKAVAEEIANKYGVKAHGVEMN 65 Query: 200 HREVNYIDKIKKYVGE--KGIDIIIEMLA 226 I+K + + GIDI++ Sbjct: 66 LLSEESINKAFEEIYNLVDGIDILVNNAG 94 >1VQ1-A nrPDB Length = 294 Score = 29.2 bits (64), Expect = 2.3, Method: Composition-based stats. Identities = 8/43 (18%), Positives = 18/43 (41%), Gaps = 4/43 (9%) Query: 150 ESVLVHG-ASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQ 191 ++V G SG +G +A+ + T + + +I + Sbjct: 135 KTVADIGTGSGAIG---VSVAKFSDAIVFATDVSSKAVEIARK 174 >6EOT-A nrPDB Length = 898 Score = 29.2 bits (64), Expect = 2.4, Method: Composition-based stats. Identities = 15/96 (15%), Positives = 30/96 (31%), Gaps = 13/96 (13%) Query: 112 HTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGE---SVL-VHGAS--------- 158 + LP+ + + FT Y L ++ G+ +VL ++G Sbjct: 622 DSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRF 681 Query: 159 GGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGA 194 GV + G ++ + + GA Sbjct: 682 KGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGA 717 >3V2G-A nrPDB Length = 271 Score = 29.2 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 20/100 (20%), Positives = 34/100 (34%), Gaps = 10/100 (10%) Query: 137 YRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIV-----LQ 191 Y + ++ AG++ V G S G+G A + G + T + Q Sbjct: 19 YFQSMMTSISLAGKTAFVTGGSRGIGAAIAKRLALEGAAVALTYVNAAERAQAVVSEIEQ 78 Query: 192 NG----AHEVFNHREVNYIDKIKKYVGE-KGIDIIIEMLA 226 G A N I++ V G+DI++ Sbjct: 79 AGGRAVAIRADNRDAEAIEQAIRETVEALGGLDILVNSAG 118 >1LQU-A nrPDB Length = 456 Score = 29.2 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 27/153 (17%), Positives = 53/153 (34%), Gaps = 21/153 (13%) Query: 90 GDRVFTSSTISGGYAE------YAL-AADHTVYKLP-EKLDFKQGAAIGIPYFTAYRALI 141 G+ V G +E YA+ A + +P E L A + ++ A+ Sbjct: 80 GNVVVGEHVQPGELSERYDAVIYAVGAQSDRMLNIPGEDLPGSIAAVDFVGWYNAHPHFE 139 Query: 142 HSACVKAGESVLVHGASGGVGLAACQIARAY--GLKILG-TAGTEEGQKIVLQNGAHEVF 198 + +G +V G G A +AR +L T + + + G EV Sbjct: 140 QVSPDLSGARAVVIGN----GNVALDVARILLTDPDVLARTDIADHALESLRPRGIQEVV 195 Query: 199 NHREVNYID------KIKKYVGEKGIDIIIEML 225 + ++++ G+D++I+ Sbjct: 196 IVGRRGPLQAAFTTLELRELADLDGVDVVIDPA 228 >4B4O-A nrPDB Length = 298 Score = 29.2 bits (64), Expect = 2.6, Method: Composition-based stats. Identities = 12/67 (17%), Positives = 25/67 (37%), Gaps = 7/67 (10%) Query: 152 VLVHGASGGVGLAACQIARAYGLKILGTAGTE-----EGQKIVLQ--NGAHEVFNHREVN 204 VLV G +G +G A Q+ A G ++ + ++ N N Sbjct: 3 VLVGGGTGFIGTALTQLLNARGHEVTLVSRKPGPGRITWDELAASGLPSCDAAVNLAGEN 62 Query: 205 YIDKIKK 211 ++ +++ Sbjct: 63 ILNPLRR 69 >3JTM-A nrPDB Length = 351 Score = 29.2 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 12/55 (21%), Positives = 24/55 (43%), Gaps = 1/55 (1%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHRE 202 G+++ GA G +G Q + +G +L + ++ + GA V + E Sbjct: 163 EGKTIGTVGA-GRIGKLLLQRLKPFGCNLLYHDRLQMAPELEKETGAKFVEDLNE 216 >1XDW-A nrPDB Length = 331 Score = 29.2 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 14/54 (25%), Positives = 20/54 (37%), Gaps = 3/54 (5%) Query: 151 SVLVHGASGGVGLAACQIARAYGLKILGTAGTEEG--QKIVLQNGAHEVFNHRE 202 +V V G G +G A QI G ++G E + Q EV + Sbjct: 148 TVGVVGL-GRIGRVAAQIFHGMGATVIGEDVFEIKGIEDYCTQVSLDEVLEKSD 200 >3X2F-A nrPDB Length = 411 Score = 29.2 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 23/131 (17%), Positives = 44/131 (33%), Gaps = 14/131 (10%) Query: 130 GIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIV 189 G T + ++ + AG++V+V G G A G +++ T Sbjct: 178 GTGQSTWDAIMRNTNLLVAGKNVVV-AGYGWCGRGIALRAAGLGARVIVTEVDPVKAVEA 236 Query: 190 LQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLS-HGGRVIVVGS 248 + +G + + + K D +I N ++ +LS G V+ Sbjct: 237 IMDGFTVM-------PMKEAVKI-----ADFVITASGNTDVLSKEDILSLKDGAVLANAG 284 Query: 249 RGTIEINPRDT 259 +EI R Sbjct: 285 HFNVEIPVRVL 295 >1QP8-A nrPDB Length = 303 Score = 29.2 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 25/156 (16%), Positives = 51/156 (32%), Gaps = 18/156 (11%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYID 207 GE V V G G +G +I A G ++ G + T + G N E + Sbjct: 123 QGEKVAVLGL-GEIGTRVGKILAALGAQVRGFSRTPKE-------GPWRFTNSLEE-ALR 173 Query: 208 KIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSII 267 + + V ++ + + + L+L++ + VG ++ + + KE Sbjct: 174 EARAAVCALPLN---KHTRGLVKYQHLALMAEDAVFVNVGRAEVLDRDGVLRILKERPQF 230 Query: 268 GVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQY 303 + E L V+ + + Sbjct: 231 ------IFASDVWWGRNDFAKDAEFFSLPNVVATPW 260 >3ORF-A nrPDB Length = 251 Score = 28.8 bits (63), Expect = 3.0, Method: Composition-based stats. Identities = 13/82 (15%), Positives = 26/82 (31%), Gaps = 11/82 (13%) Query: 150 ESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVF---NHREVNYI 206 +++LV G SG +G + ++ + E A F + E Sbjct: 23 KNILVLGGSGALGAEVVKFFKSKSWNTISIDFRENPN-------ADHSFTIKDSGEEEIK 75 Query: 207 DKIKKYVGEK-GIDIIIEMLAN 227 I+K + +D + Sbjct: 76 SVIEKINSKSIKVDTFVCAAGG 97 >1KZH-A nrPDB Length = 555 Score = 28.8 bits (63), Expect = 3.1, Method: Composition-based stats. Identities = 8/42 (19%), Positives = 16/42 (38%), Gaps = 5/42 (11%) Query: 126 GAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQ 167 + + T Y + I + +K + + +GGV L Sbjct: 450 AVVLILNGLTGYMSCIKNLNLKPTDWI-----AGGVPLTMLM 486 >2X86-A nrPDB Length = 357 Score = 28.8 bits (63), Expect = 3.1, Method: Composition-based stats. Identities = 18/113 (15%), Positives = 40/113 (35%), Gaps = 14/113 (12%) Query: 152 VLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKK 211 ++V G +G +G + G+ + L++G + N ++N D + K Sbjct: 49 IIVTGGAGFIGSNIVKALNDKGITDILVVDN-------LKDG-TKFVNLVDLNIADYMDK 100 Query: 212 YVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKES 264 D +I+++A ++ G G ++ +KE Sbjct: 101 E------DFLIQIMAGEEFGDVEAIFHEGACSSTTEWDGKYMMDNNYQYSKEL 147 >1EQ2-A nrPDB Length = 310 Score = 28.8 bits (63), Expect = 3.1, Method: Composition-based stats. Identities = 18/113 (15%), Positives = 40/113 (35%), Gaps = 14/113 (12%) Query: 152 VLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKK 211 ++V G +G +G + G+ + L++G + N ++N D + K Sbjct: 2 IIVTGGAGFIGSNIVKALNDKGITDILVVDN-------LKDG-TKFVNLVDLNIADYMDK 53 Query: 212 YVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKES 264 D +I+++A ++ G G ++ +KE Sbjct: 54 E------DFLIQIMAGEEFGDVEAIFHEGACSSTTEWDGKYMMDNNYQYSKEL 100 >3ZV3-A nrPDB Length = 281 Score = 28.8 bits (63), Expect = 3.3, Method: Composition-based stats. Identities = 10/38 (26%), Positives = 16/38 (42%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQ 186 GE L+ G + G+G A A G ++ + E Sbjct: 5 GEVALITGGASGLGRALVDRFVAEGARVAVLDKSAERL 42 >2AS0-A nrPDB Length = 396 Score = 28.8 bits (63), Expect = 3.3, Method: Composition-based stats. Identities = 11/47 (23%), Positives = 20/47 (42%), Gaps = 4/47 (8%) Query: 146 VKAGESVL-VHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQ 191 V+ G+ VL V +GG A A A +++G + + + Sbjct: 215 VQPGDRVLDVFTYTGG---FAIHAAIAGADEVIGIDKSPRAIETAKE 258 Score = 28.4 bits (62), Expect = 4.4, Method: Composition-based stats. Identities = 12/42 (28%), Positives = 20/42 (47%), Gaps = 1/42 (2%) Query: 87 FKKGDRVFTSSTISGGYAEY-ALAADHTVYKLPEKLDFKQGA 127 + GDRV T +GG+A + A+A V + + + A Sbjct: 215 VQPGDRVLDVFTYTGGFAIHAAIAGADEVIGIDKSPRAIETA 256 >4RGB-A nrPDB Length = 294 Score = 28.8 bits (63), Expect = 3.4, Method: Composition-based stats. Identities = 26/149 (17%), Positives = 52/149 (34%), Gaps = 11/149 (7%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDK 208 G V + GA+ G G + + G I+G E+ + + G + E+ + Sbjct: 25 GRVVFITGAARGQGRSHAVMCAEQGANIVGVDICEDIDIVPYKLG-----TYEELEETAR 79 Query: 209 IKKYVGE----KGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKES 264 + + G+ + D+ + + + H VI + G + NP + A E+ Sbjct: 80 LVEKTGQEMLFRKADVRDKAVLQEVFDAGVEQFGHIDTVIA--NAGVVLTNPDERDASEA 137 Query: 265 SIIGVTLFSSTKEEFQQYAAALQAGMEIG 293 +G+ + Q A G Sbjct: 138 LRLGLDIMLIGVWNTFQVAIPHMKERGQG 166 >5HMP-A nrPDB Length = 750 Score = 28.8 bits (63), Expect = 3.4, Method: Composition-based stats. Identities = 18/90 (20%), Positives = 37/90 (41%), Gaps = 13/90 (14%) Query: 76 VIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHT-VYKLPEKLDFKQGAAIGIPYF 134 + + A ++ GD+V G +Y++ + + P+ L +G Sbjct: 16 EVWKSAEIAKDYRVGDKVLRLLLEDGTELDYSVNPESLPPLRNPDIL-------VGENDL 68 Query: 135 TAYR-----ALIHSACVKAGESVLVHGASG 159 TA A++H+ ++ ES L++ SG Sbjct: 69 TALSYLHEPAVLHNLRIRFAESKLIYTYSG 98 >3RD8-A nrPDB Length = 489 Score = 28.8 bits (63), Expect = 3.7, Method: Composition-based stats. Identities = 28/148 (18%), Positives = 46/148 (31%), Gaps = 16/148 (10%) Query: 37 QVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKK------- 89 +VL A T ++SG +P T G + G + K Sbjct: 183 EVLHASLAAKAKQWRTVVKSGRTHLMDAVPVTLGQEFGGYARQIEAGIERVKATLPRLGE 242 Query: 90 ----GDRVFTSSTISGGYAEYAL---AADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIH 142 G V T G+ + + + +L +D + A A AL Sbjct: 243 LAIGGTAVGTGLNAPEGFGAKVVEVLVNETGLAELRTAVDSFEAQAARDGLVEASGALRT 302 Query: 143 SA-CVKAGESVLVHGASGGV-GLAACQI 168 A + + + SG + GLA Q+ Sbjct: 303 IAVSLTKIANDIRWMGSGPLTGLAEIQL 330 >5JXW-A nrPDB Length = 498 Score = 28.8 bits (63), Expect = 3.7, Method: Composition-based stats. Identities = 11/47 (23%), Positives = 19/47 (40%), Gaps = 2/47 (4%) Query: 138 RALIHSA-CVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTE 183 L + + AG+ ++V G G VG Q G +++ T Sbjct: 259 HGLFNGCIQMLAGKKIVVLG-YGEVGKGCAQGLSGVGARVIVTEIDP 304 >4QUK-A nrPDB Length = 319 Score = 28.4 bits (62), Expect = 3.9, Method: Composition-based stats. Identities = 12/61 (19%), Positives = 24/61 (39%), Gaps = 4/61 (6%) Query: 152 VLVHGASGGVGLAACQIARAYGLKILGTAG---TEEGQKIVLQN-GAHEVFNHREVNYID 207 V V GASG + ++ G + T + +++ GA E + N ++ Sbjct: 3 VCVTGASGYIASWLVRLLLHRGYTVKATVRDPNDPKKVDHLVKLDGAKERLQLFKANLLE 62 Query: 208 K 208 + Sbjct: 63 E 63 >4LAT-A nrPDB Length = 265 Score = 28.4 bits (62), Expect = 4.0, Method: Composition-based stats. Identities = 14/49 (28%), Positives = 22/49 (44%), Gaps = 5/49 (10%) Query: 124 KQGAAIGIPYFTAYRALIHSA-----CVKAGESVLVHGASGGVGLAACQ 167 +G +I TA + L+ A + G++V V G G GL+ Q Sbjct: 1 DRGESITAVGSTALQPLVEVAADEFGTIHVGKTVNVQGGGSGTGLSQVQ 49 >3W8F-A nrPDB Length = 260 Score = 28.4 bits (62), Expect = 4.1, Method: Composition-based stats. Identities = 15/90 (16%), Positives = 39/90 (43%), Gaps = 13/90 (14%) Query: 149 GESVLVHGASGGVGL-AACQIARAYGLKILGT------AGTEEGQKIVLQNGAHEVFNHR 201 G+ +V G++ G+GL A ++A+A G ++ E + + G + + Sbjct: 4 GKKAVVTGSTSGIGLAMATELAKA-GADVVINGFGQPEDIERERSTLESKFGVKAYYLNA 62 Query: 202 EVNYIDKIKKYVGE-----KGIDIIIEMLA 226 +++ + ++ + G+DI++ Sbjct: 63 DLSDAQATRDFIAKAAEALGGLDILVNNAG 92 >1SMK-A nrPDB Length = 326 Score = 28.4 bits (62), Expect = 4.2, Method: Composition-based stats. Identities = 7/24 (29%), Positives = 12/24 (50%) Query: 148 AGESVLVHGASGGVGLAACQIARA 171 G V + GA+GG+G + + Sbjct: 7 PGFKVAILGAAGGIGQPLAMLMKM 30 >3HDH-A nrPDB Length = 302 Score = 28.4 bits (62), Expect = 4.2, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 18/42 (42%), Gaps = 1/42 (2%) Query: 150 ESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQ 191 + V V G G +G Q+A A G ++ TE+ + Sbjct: 16 KHVTVIGG-GLMGAGIAQVAAATGHTVVLVDQTEDILAKSKK 56 >5XJ2-A nrPDB Length = 454 Score = 28.4 bits (62), Expect = 4.2, Method: Composition-based stats. Identities = 15/81 (18%), Positives = 34/81 (41%), Gaps = 8/81 (9%) Query: 137 YRALIHSACVKAGESVLVHGASGGVGLAACQIARA----YGLKIL--GTAGTEEGQKIVL 190 Y+ I A +K + ++ A G+G +A+ YG++++ +++ + Sbjct: 293 YQTAIDFAELKKDD--VIIDAYSGIGTIGLSVAKHVKEVYGVELIPEAVENSQKNASLNK 350 Query: 191 QNGAHEVFNHREVNYIDKIKK 211 AH V + E +K+ Sbjct: 351 ITNAHYVCDTAENAMKKWLKE 371 >3KTC-A nrPDB Length = 333 Score = 28.4 bits (62), Expect = 4.3, Method: Composition-based stats. Identities = 7/47 (14%), Positives = 15/47 (31%), Gaps = 9/47 (19%) Query: 71 SDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKL 117 + AG++ +G N G + + ++KL Sbjct: 110 HESAGIVRELGANYVKVWPGQDGWDYPFQ---------VSHKNLWKL 147 >2AG5-A nrPDB Length = 246 Score = 28.4 bits (62), Expect = 4.3, Method: Composition-based stats. Identities = 10/74 (13%), Positives = 26/74 (35%), Gaps = 10/74 (13%) Query: 173 GLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSK 232 G K++ T E + + + ++ +K ID + +++ Sbjct: 30 GAKVIATDINESKLQELEKY----------PGIQTRVLDVTKKKQIDQFANEVERLDVLF 79 Query: 233 DLSLLSHGGRVIVV 246 +++ H G V+ Sbjct: 80 NVAGFVHHGTVLDC 93 >1DOH-A nrPDB Length = 283 Score = 28.4 bits (62), Expect = 4.4, Method: Composition-based stats. Identities = 20/94 (21%), Positives = 33/94 (35%), Gaps = 10/94 (10%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILG-----TAGTEEGQKIVLQNGAHEVFNHRE 202 G+ LV GA G+G G K++ T EE + +NG+ Sbjct: 28 EGKVALVTGAGRGIGREMAMELGRRGCKVIVNYANSTESAEEVVAAIKKNGSDAACVKAN 87 Query: 203 VNYIDKIKKYVGE-----KGIDIIIEMLANVNLS 231 V ++ I + E +DI+ V+ Sbjct: 88 VGVVEDIVRMFEEAVKIFGKLDIVCSNSGVVSFG 121 >4CR6-A nrPDB Length = 271 Score = 28.4 bits (62), Expect = 4.4, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 18/36 (50%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTE 183 AG++ +V GA+GG+G A + G ++ Sbjct: 14 AGKAAIVTGAAGGIGRATVEAYLREGASVVAMDLAP 49 >2EEZ-A nrPDB Length = 369 Score = 28.4 bits (62), Expect = 4.6, Method: Composition-based stats. Identities = 10/39 (25%), Positives = 18/39 (46%), Gaps = 1/39 (2%) Query: 151 SVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIV 189 SV++ G G VG A +IA G ++ + + + Sbjct: 168 SVVILGG-GTVGTNAAKIALGMGAQVTILDVNHKRLQYL 205 >1F14-A nrPDB Length = 310 Score = 28.4 bits (62), Expect = 4.6, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 18/42 (42%), Gaps = 1/42 (2%) Query: 150 ESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQ 191 + V V G G +G Q+A A G ++ TE+ + Sbjct: 16 KHVTVIGG-GLMGAGIAQVAAATGHTVVLVDQTEDILAKSKK 56 >1W7I-A nrPDB Length = 795 Score = 28.4 bits (62), Expect = 4.8, Method: Composition-based stats. Identities = 21/96 (21%), Positives = 33/96 (34%), Gaps = 10/96 (10%) Query: 76 VIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFT 135 + + +K GD+V G EY L D +G T Sbjct: 20 EVWKSAELLKDYKPGDKVLQLRLEEGKDLEYCLDPKTKELPPLRNPDI----LVGENDLT 75 Query: 136 AYR-----ALIHSACVKAGESVLVHGASGGVGLAAC 166 A A++H+ V+ +S L++ G V L A Sbjct: 76 ALSYLHEPAVLHNLKVRFIDSKLIYTYCGIV-LVAI 110 >6JCV-A nrPDB Length = 333 Score = 28.4 bits (62), Expect = 4.9, Method: Composition-based stats. Identities = 30/187 (16%), Positives = 62/187 (33%), Gaps = 21/187 (11%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGA-----HEVFNHREV 203 G+++ V G G G I R GL ++ ++ ++ + G E +V Sbjct: 15 GKTIGVIG-YGNQGRVQATIMRENGLNVIVGNVKDKYYELAKKEGFEVYEIDEAVRRSDV 73 Query: 204 NYI---DKIKKYVGEKGI--------DIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTI 252 + D++ K V EK I + +++ + + L+ V + + Sbjct: 74 ALLLIPDEVMKEVYEKKIAPVLQGKKEFVLDFASG--YNVAFGLIRPPKSVDTIMVAPRM 131 Query: 253 EINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAH 312 + K+ V L + + A IG + I E+ EA Sbjct: 132 VGEGIMDLHKQGKGYPVLLGVKQDASGKAWDYAKAIAKGIGAIPGGIAVISSFEE--EAL 189 Query: 313 ENIIHGS 319 +++ Sbjct: 190 LDLMSEH 196 >6ABI-A nrPDB Length = 358 Score = 28.0 bits (61), Expect = 5.2, Method: Composition-based stats. Identities = 10/48 (20%), Positives = 22/48 (45%), Gaps = 2/48 (4%) Query: 150 ESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEV 197 ++ + G +G +G +I R + +K++ QK+ + G V Sbjct: 170 KTAGIIG-TGKIGQILIKILRGFDMKVIAYDLFP-NQKVADELGFEYV 215 >4D3F-A nrPDB Length = 310 Score = 28.0 bits (61), Expect = 5.2, Method: Composition-based stats. Identities = 21/93 (22%), Positives = 33/93 (35%), Gaps = 3/93 (3%) Query: 150 ESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDK- 208 +SV V G G +G A + YG + T ++ GA V E ++ Sbjct: 22 KSVTVIGL-GPMGQAMADVFLEYGYSVTVWNRTSSKADQLVAKGAIRVSTVNEALAANEL 80 Query: 209 -IKKYVGEKGIDIIIEMLANVNLSKDLSLLSHG 240 I + I+E ++ K L LS Sbjct: 81 VILSLTDYNVMYSILEPVSENLFGKVLVNLSSD 113 >2QRJ-A nrPDB Length = 394 Score = 28.0 bits (61), Expect = 5.2, Method: Composition-based stats. Identities = 22/92 (23%), Positives = 31/92 (33%), Gaps = 11/92 (11%) Query: 90 GDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTA--------YRALI 141 G RV +G +A AL +K D A P A Y+ + Sbjct: 150 GRRVAAFGFYAG-FAGAALGVRDWAFKQTHSDDEDLPAVSPYPNEKALVKDVTKDYKEAL 208 Query: 142 HSACVKAGESVLVHGASGGVGLAACQIARAYG 173 + K +VL+ GA G G A + G Sbjct: 209 ATGARKP--TVLIIGALGRCGSGAIDLLHKVG 238 >6A0L-A nrPDB Length = 471 Score = 28.0 bits (61), Expect = 5.5, Method: Composition-based stats. Identities = 12/58 (20%), Positives = 21/58 (36%), Gaps = 3/58 (5%) Query: 194 AHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGT 251 A N+ + I + + GID L ++ H G + ++GS T Sbjct: 265 ADGTMNYTARDL---ILGFTADGGIDASALAAGLNALHAEIPAGFHRGMLNLLGSHDT 319 >2CB1-A nrPDB Length = 412 Score = 28.0 bits (61), Expect = 5.6, Method: Composition-based stats. Identities = 18/108 (16%), Positives = 34/108 (31%), Gaps = 12/108 (11%) Query: 147 KAGESVLVHGASGGVGLAAC---QIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREV 203 + G+ V+ A G G Q+ G+ + E + L VF Sbjct: 93 RPGDEVV--AAKGLFGQTIGLFGQVLSLMGVTVRYVDPEPEAVREALSAKTRAVFVETVA 150 Query: 204 NYI------DKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIV 245 N + + E G+ ++++ L+ G V+V Sbjct: 151 NPALLVPDLEALATLAEEAGVALVVDNTFGAA-GALCRPLAWGAHVVV 197 >3GNQ-A nrPDB Length = 344 Score = 28.0 bits (61), Expect = 5.8, Method: Composition-based stats. Identities = 9/55 (16%), Positives = 24/55 (43%), Gaps = 1/55 (1%) Query: 214 GEKGIDIIIEMLANVNL-SKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSII 267 GE G+D+++E K + L G + +++ + G +++ ++ Sbjct: 97 GELGVDVVMECTGFFTSKEKASAHLKGGAKKVIISAPGGKDVDATIVYGVNHDVL 151 >4HGV-A nrPDB Length = 495 Score = 28.0 bits (61), Expect = 6.2, Method: Composition-based stats. Identities = 13/68 (19%), Positives = 21/68 (30%), Gaps = 11/68 (16%) Query: 51 ETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAF-----------KKGDRVFTSSTI 99 + I+ G + P T G + +G V + + G V T Sbjct: 211 DHIIKIGRTHTQDATPLTLGQEFSGYAAQVASSIKRIEMTLPGLCELAQGGTAVGTGLNA 270 Query: 100 SGGYAEYA 107 G+AE Sbjct: 271 PVGFAEKV 278 >4OMU-A nrPDB Length = 283 Score = 28.0 bits (61), Expect = 6.5, Method: Composition-based stats. Identities = 25/149 (16%), Positives = 48/149 (32%), Gaps = 12/149 (8%) Query: 148 AGESVLVHGASGGV-GLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYI 206 AG+ +L+ GA G V G+ +A ++ E+ +++ + E+ + Sbjct: 118 AGKRILILGAGGAVRGVLEPILAHKPQSLVIANRTVEKAEQLAREF--------DELGPV 169 Query: 207 DKIKKYVGEKGIDIIIEMLANV---NLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKE 263 ++ +D+II + L L GR + E P A + Sbjct: 170 VASGFAWLQEPVDVIINATSASLAGELPPIADSLVEAGRTVCYDMMYGKEPTPFCQWATK 229 Query: 264 SSIIGVTLFSSTKEEFQQYAAALQAGMEI 292 V E A + G+ Sbjct: 230 LGAAKVLDGLGMLAEQAAEAFFIWRGVRP 258 >6C55-A nrPDB Length = 340 Score = 28.0 bits (61), Expect = 6.6, Method: Composition-based stats. Identities = 11/63 (17%), Positives = 18/63 (28%), Gaps = 1/63 (1%) Query: 134 FTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNG 193 T Y G+ + V G G G A Q + G ++ ++G Sbjct: 2 TTVYYDQDVKTDALQGKKIAVVG-YGSQGHAHAQNLKDNGYDVVIGIRPGRSFDKAKEDG 60 Query: 194 AHE 196 Sbjct: 61 FDV 63 >1YXM-A nrPDB Length = 303 Score = 27.6 bits (60), Expect = 6.7, Method: Composition-based stats. Identities = 9/45 (20%), Positives = 18/45 (40%) Query: 145 CVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIV 189 + G+ +V G + G+G A + G ++ + E K Sbjct: 14 GLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSA 58 >1URG-A nrPDB Length = 402 Score = 27.6 bits (60), Expect = 7.0, Method: Composition-based stats. Identities = 14/86 (16%), Positives = 30/86 (34%), Gaps = 22/86 (25%) Query: 142 HSACVKAGESVLVHGASGG-----VGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHE 196 ++ + G+++ V G V A Q A+A+G K++ + Sbjct: 22 EASALPKGQTITVWSWQTGPELQDVKQIAAQWAKAHGDKVIVVDQSS------------- 68 Query: 197 VFNHREVNYIDKIKKYVGEKGIDIII 222 N + + + KG D++ Sbjct: 69 --NPKGFQFYATAAR--TGKGPDVVF 90 >6J0Z-C nrPDB Length = 491 Score = 27.6 bits (60), Expect = 7.3, Method: Composition-based stats. Identities = 23/116 (19%), Positives = 34/116 (29%), Gaps = 9/116 (7%) Query: 150 ESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDK- 208 V+V GA G GL R G+ ++ E K G + + Sbjct: 6 SDVVVVGA-GPTGLMLAGELRLAGVSVVVLDKLAEPIKESRALGFSA---RTIEEFAQRG 61 Query: 209 IKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKES 264 + GE G+ I + V L + GG G A+E Sbjct: 62 LMDRFGEVGV-IPVGHFGGVPLD---YQVIEGGSYGARGIPQARTEGILGGWAREL 113 >3UF0-A nrPDB Length = 273 Score = 27.6 bits (60), Expect = 7.4, Method: Composition-based stats. Identities = 17/86 (19%), Positives = 31/86 (36%), Gaps = 7/86 (8%) Query: 148 AGESVLVHGASGGVGLAACQIARAYGLKILG---TAGTEEGQKIVLQNG--AHEVFN--H 200 AG + +V GA G+G A G +L T G +E + G A V Sbjct: 30 AGRTAVVTGAGSGIGRAIAHGYARAGAHVLAWGRTDGVKEVADEIADGGGSAEAVVADLA 89 Query: 201 REVNYIDKIKKYVGEKGIDIIIEMLA 226 + ++ + +D+++ Sbjct: 90 DLEGAANVAEELAATRRVDVLVNNAG 115 >3CJR-A nrPDB Length = 254 Score = 27.6 bits (60), Expect = 7.4, Method: Composition-based stats. Identities = 17/74 (22%), Positives = 26/74 (35%), Gaps = 13/74 (17%) Query: 130 GIPYFTAYRALIHSA------CVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGT- 182 G+ + T + A ++ G+ VL G GV A A G K LG Sbjct: 96 GMAFGTGHHETTRLALKALARHLRPGDKVLDLGTGSGVLAIA---AEKLGGKALGVDIDP 152 Query: 183 ---EEGQKIVLQNG 193 + + +NG Sbjct: 153 MVLPQAEANAKRNG 166 >3F4W-A nrPDB Length = 211 Score = 27.6 bits (60), Expect = 7.5, Method: Composition-based stats. Identities = 22/171 (12%), Positives = 53/171 (30%), Gaps = 20/171 (11%) Query: 116 KLPEKLDFKQGAA--IGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYG 173 K+ + +D + + A +A+ + VL G Q+ G Sbjct: 21 KVVDDVDIIEVGTPFLIREGVNAIKAIKEKY---PHKEVLADAKIMDGGHFESQLLFDAG 77 Query: 174 LKILGTAGTEEGQ------KIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIII----- 222 + G + + + G V + V+ + + + E G D++ Sbjct: 78 ADYVTVLGVTDVLTIQSCIRAAKEAGKQVVVDMICVDDLPARVRLLEEAGADMLAVHTGT 137 Query: 223 --EMLANVNLSKDLSLL--SHGGRVIVVGSRGTIEINPRDTMAKESSIIGV 269 + + +++L R+ V G + + + + I+G Sbjct: 138 DQQAAGRKPIDDLITMLKVRRKARIAVAGGISSQTVKDYALLGPDVVIVGS 188 >3WTC-A nrPDB Length = 262 Score = 27.6 bits (60), Expect = 7.6, Method: Composition-based stats. Identities = 22/151 (14%), Positives = 46/151 (30%), Gaps = 22/151 (14%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQ-KIVLQNGAHEVFNHREVNYID 207 G+ V GA+ G+G A G ++ ++ + + Sbjct: 8 GKIAAVTGAAQGIGKAIALRLAKDGADVILLDVKQDTLAETAKEV--------------- 52 Query: 208 KIKKYVGEKGIDIIIEMLANVNLSKDLSLLSH--GGRVIVVGSRGTIEINP-RDTMAKES 264 + +G + + + ++ L+ + GG I+V + G ++ P D E Sbjct: 53 ---EALGRRAVALTADISNRDQFRSTLADAAKTLGGLDIMVNNAGICQVKPILDIEPAEI 109 Query: 265 SIIGVTLFSSTKEEFQQYAAALQAGMEIGWL 295 I Q A + G + Sbjct: 110 EKIFSINVQGVLWGMQAAATLFKEKGTKGKI 140 >2DKN-A nrPDB Length = 255 Score = 27.6 bits (60), Expect = 7.6, Method: Composition-based stats. Identities = 17/145 (11%), Positives = 43/145 (29%), Gaps = 7/145 (4%) Query: 152 VLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKK 211 + + G++ G+G A ++ G ++G + + A + + Sbjct: 4 IAITGSASGIGAALKELLARAGHTVIGIDRGQADIE------ADLSTPGGRETAVAAVLD 57 Query: 212 YVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTL 271 G +D ++ + + L+ V + + I+G Sbjct: 58 RCGGV-LDGLVCCAGVGVTAANSGLVVAVNYFGVSALLDGLAEALSRGQQPAAVIVGSIA 116 Query: 272 FSSTKEEFQQYAAALQAGMEIGWLK 296 + A+ AG E ++ Sbjct: 117 ATQPGAAELPMVEAMLAGDEARAIE 141 >4UZU-A nrPDB Length = 513 Score = 27.6 bits (60), Expect = 7.8, Method: Composition-based stats. Identities = 14/54 (25%), Positives = 22/54 (40%), Gaps = 8/54 (14%) Query: 163 LAACQIARAYGLKILGTAGTEEGQKIVLQNGAH--EVFNHREVNYIDKIKKYVG 214 L A Q A A G+++ + GA E + EVN D+ ++ G Sbjct: 85 LQAIQAAHAAGMQVYADVVFDHKG------GADGTEWVDAVEVNPSDRNQEISG 132 >3KWM-A nrPDB Length = 224 Score = 27.6 bits (60), Expect = 7.9, Method: Composition-based stats. Identities = 21/129 (16%), Positives = 43/129 (33%), Gaps = 10/129 (7%) Query: 139 ALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEV- 197 A +A E L G VG ++ + +E+ + + G V Sbjct: 16 AATEAAKSITTEITLGVGTGSTVGFLIEELVNYRDKIKTVVSSSEDSTRKLKALGFDVVD 75 Query: 198 FNHREV-----NYIDKI---KKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGS- 248 N+ + D+ K+ + G + E + K + ++ +V +G+ Sbjct: 76 LNYAGEIDLYIDGADECNNHKELIKGGGAALTREKICVAAAKKFICIIDESKKVNTLGNF 135 Query: 249 RGTIEINPR 257 IE+ P Sbjct: 136 PLPIEVIPM 144 >6APE-A nrPDB Length = 298 Score = 27.6 bits (60), Expect = 8.2, Method: Composition-based stats. Identities = 10/48 (20%), Positives = 16/48 (33%) Query: 129 IGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKI 176 + R L H G+ V + GAS +G + G + Sbjct: 150 LPATPMGVMRLLKHYHIEIKGKDVAIIGASNIIGKPLSMLMLNAGASV 197 >5XEM-A nrPDB Length = 310 Score = 27.3 bits (59), Expect = 9.4, Method: Composition-based stats. Identities = 23/112 (20%), Positives = 42/112 (37%), Gaps = 40/112 (35%) Query: 150 ESVLVHGASG--GVGLAAC---------------------QIARAYGLKILGTAGT---- 182 ++V++ SG G+GLA Q+ RAYG +++ T G+ Sbjct: 66 DTVIIEATSGNTGIGLAMICAVKNYKLKIVMPDTMSIERIQLMRAYGTEVILTDGSLGMK 125 Query: 183 --EEGQKIVLQ--------NGAHEVFNHRE--VNYIDKIKKYVGEKGIDIII 222 E + + + N V N + ++I K + K +D+ I Sbjct: 126 ACLEKLEELKKNEKKYFVPNQFTNVNNPKAHYETTAEEILKDLNNK-VDVFI 176 >2HQ1-A nrPDB Length = 247 Score = 27.3 bits (59), Expect = 9.4, Method: Composition-based stats. Identities = 16/88 (18%), Positives = 33/88 (37%), Gaps = 10/88 (11%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKIL-----GTAGTEEGQKIVLQNGAHEVFNHRE- 202 G++ +V G+S G+G A G I+ + + + G + V + Sbjct: 5 GKTAIVTGSSRGLGKAIAWKLGNMGANIVLNGSPASTSLDATAEEFKAAGINVVVAKGDV 64 Query: 203 ---VNYIDKIKKYVGEKG-IDIIIEMLA 226 + + +K + G IDI++ Sbjct: 65 KNPEDVENMVKTAMDAFGRIDILVNNAG 92 >2FWM-X nrPDB Length = 250 Score = 27.3 bits (59), Expect = 9.6, Method: Composition-based stats. Identities = 15/80 (18%), Positives = 31/80 (38%), Gaps = 5/80 (6%) Query: 149 GESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDK 208 G++V V GA G+G A G K+ G ++ A EV + + + + Sbjct: 7 GKNVWVTGAGKGIGYATALAFVEAGAKVTGFDQAFTQEQYPF---ATEVMDVADAAQVAQ 63 Query: 209 I--KKYVGEKGIDIIIEMLA 226 + + + +D ++ Sbjct: 64 VCQRLLAETERLDALVNAAG 83 >1A27-A nrPDB Length = 289 Score = 27.3 bits (59), Expect = 9.6, Method: Composition-based stats. Identities = 15/88 (17%), Positives = 32/88 (36%), Gaps = 13/88 (14%) Query: 152 VLVHGASGGVG-LAACQIAR--AYGLKILGTAGTEEGQ----KIVLQNGA------HEVF 198 VL+ G S G+G A ++A + K+ T + Q + Sbjct: 5 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 64 Query: 199 NHREVNYIDKIKKYVGEKGIDIIIEMLA 226 + R+ + ++ V E +D+++ Sbjct: 65 DVRDSKSVAAARERVTEGRVDVLVCNAG 92 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.313 0.141 0.368 Lambda K H 0.267 0.0430 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,819,622 Number of Sequences: 36641 Number of extensions: 570943 Number of successful extensions: 3657 Number of sequences better than 10.0: 390 Number of HSP's better than 10.0 without gapping: 287 Number of HSP's successfully gapped in prelim test: 225 Number of HSP's that attempted gapping in prelim test: 2690 Number of HSP's gapped (non-prelim): 611 length of query: 329 length of database: 10,336,785 effective HSP length: 97 effective length of query: 232 effective length of database: 6,782,608 effective search space: 1573565056 effective search space used: 1573565056 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 59 (27.3 bits)