BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q06142 (861 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5OWU-A nrPDB 1769 0.0 4XRI-A nrPDB 615 e-176 2Q5D-A nrPDB 464 e-131 2QNA-A nrPDB 417 e-117 1M5N-S nrPDB 329 4e-90 4B8J-A nrPDB 34 0.21 4B8O-A nrPDB 34 0.34 3GNN-A nrPDB 33 0.52 4ILH-B nrPDB 32 1.3 4I43-A nrPDB 32 1.6 1WA5-B nrPDB 30 3.2 6BQN-B nrPDB 30 3.4 4A4Z-A nrPDB 30 3.5 5VQI-B nrPDB 30 3.7 1UN0-A nrPDB 30 4.7 1PYP-A nrPDB 29 6.8 4AKX-B nrPDB 29 7.4 >5OWU-A nrPDB Length = 861 Score = 1769 bits (4581), Expect = 0.0, Method: Compositional matrix adjust. Identities = 861/861 (100%), Positives = 861/861 (100%) Query: 1 MSTAEFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRIL 60 MSTAEFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRIL Sbjct: 1 MSTAEFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRIL 60 Query: 61 AALTLKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIA 120 AALTLKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIA Sbjct: 61 AALTLKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIA 120 Query: 121 AIADIELPHGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNI 180 AIADIELPHGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNI Sbjct: 121 AIADIELPHGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNI 180 Query: 181 LIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEV 240 LIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEV Sbjct: 181 LIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEV 240 Query: 241 QAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDI 300 QAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDI Sbjct: 241 QAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDI 300 Query: 301 AYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQ 360 AYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQ Sbjct: 301 AYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQ 360 Query: 361 NCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLM 420 NCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLM Sbjct: 361 NCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLM 420 Query: 421 NDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINL 480 NDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINL Sbjct: 421 NDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINL 480 Query: 481 VEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSA 540 VEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSA Sbjct: 481 VEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSA 540 Query: 541 SISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMG 600 SISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMG Sbjct: 541 SISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMG 600 Query: 601 LFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDSPVSITAV 660 LFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDSPVSITAV Sbjct: 601 LFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDSPVSITAV 660 Query: 661 GFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPY 720 GFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPY Sbjct: 661 GFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPY 720 Query: 721 LNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIF 780 LNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIF Sbjct: 721 LNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIF 780 Query: 781 QFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSGQLF 840 QFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSGQLF Sbjct: 781 QFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSGQLF 840 Query: 841 SQATKDTARWAREQQKRQLSL 861 SQATKDTARWAREQQKRQLSL Sbjct: 841 SQATKDTARWAREQQKRQLSL 861 >4XRI-A nrPDB Length = 882 Score = 615 bits (1585), Expect = e-176, Method: Compositional matrix adjust. Identities = 342/863 (39%), Positives = 524/863 (60%), Gaps = 15/863 (1%) Query: 9 LLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRILAALTLKNE 68 +LENS LSPD +R +E QL + NF Q+ Q L +E+++ R A + LKN Sbjct: 15 ILENS-LSPDATLRHAAEQQLTHAAETNFSQYLLTLVQALANESSEGHIRAAAGIALKNA 73 Query: 69 LVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIADIELP 128 +++ + +W+ Q E + ++K AL L S + AAAQ+IAAIA IELP Sbjct: 74 FSAREFARQAALQAKWLNQTDQETRTRVKQLALETLASPNSKAGQAAAQVIAAIAAIELP 133 Query: 129 HGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESADPQ-SQALVSSSNNILIAIVQG 187 WPELM +V N +E ++ K+ASL A+G++CE+ D +LV SN IL A+VQG Sbjct: 134 RNQWPELMHALVRN-ASEGGQHQKQASLTAIGFICETQDTDLRNSLVGHSNAILTAVVQG 192 Query: 188 AQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGC 247 A+ E + VR AA+ AL DSL F+ NN + EGERNY+MQVVCEATQA+D +Q AFGC Sbjct: 193 ARKEEPNNEVRFAAITALGDSLEFVGNNFKHEGERNYIMQVVCEATQAQDSRIQQGAFGC 252 Query: 248 LCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQF 307 L +IM+LYY M+ YME+AL+ LTI MKS ++ VA + VEFWST+CEEEI I + AQ Sbjct: 253 LNRIMALYYEHMRYYMEKALFGLTILGMKSDDEDVAKLAVEFWSTVCEEEIAIEDDNAQV 312 Query: 308 PQSPLQS--YNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGNH 365 S YNFA + +VVP LL LLT+Q+ED DD++N+S +A CLQL+AQ G+ Sbjct: 313 ESSEQMRPFYNFARVATNEVVPVLLQLLTKQDEDASDDEYNISRAAYQCLQLYAQAVGST 372 Query: 366 ILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSL 425 I+ PV++FVE N+ +W R+AAV AFG+IMDGP++ V + ++ +M D+S+ Sbjct: 373 IIPPVIQFVEHNLRHADWHFRDAAVSAFGAIMDGPEEKVLEPIVKTGMQPLIAMMEDESI 432 Query: 426 QVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLA 485 QV+++TA+ +GRI ++ +E+IDP HL ++++ GL + PK+A +C W ++N+ E+ A Sbjct: 433 QVRDSTAYALGRITEACSEAIDPNTHLEPLIRSLFNGLMNSPKMAASCCWALMNIAERFA 492 Query: 486 ---EATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASI 542 A +P+ + V L+ ++ + R +A+ L+ V+ A + AS+ Sbjct: 493 GEPGAAQNPLTPHFNQSVTNLLTVTAPMNGDSTVRTAAYEVLSVFVQNAANDSLSAVASL 552 Query: 543 STFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMGLF 602 ST ++ +L +T+ + + +++ED L+++Q+++ TVL A +++ + P D +M + Sbjct: 553 STVILQRLEETLPLQQQVVSVEDKLILEDMQTSLCTVLQATVQRLDKEIAPQGDRIMQVL 612 Query: 603 FRLLEK-KDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKAL-NQVDSPVSITAV 660 ++L + + + VF AISALA ++ + F KY+E F+P+L AL NQ + + A+ Sbjct: 613 LQILSTCGGKSSVPEGVFAAISALANAMEEEFAKYMEAFAPFLYNALGNQEEPSLCSMAI 672 Query: 661 GFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPY 720 G ++D++ SL E + Y D MN L + + + KPA+L FGDIAS IG F Y Sbjct: 673 GLVSDVTRSLGERSQPYCDNFMNYLLGNLRSTTLANQFKPAILQCFGDIASAIGGHFETY 732 Query: 721 LNDI-MALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLH--DKPEALFPYVG 777 L + L AA T +G+ E +DY I + E ++DA+ GI+ + +K L PYV Sbjct: 733 LTIVAQVLQQAATITAGPDGSYEMIDYVISLREGIMDAWGGIIGAMKTSNKTNVLQPYVE 792 Query: 778 TIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSG 837 +IF + +A DP +A RA++G+IGD+A +P+G + + QDW+ I+ TRS Sbjct: 793 SIFALLNSIANDPN--RSEALMRASMGVIGDLADAYPNGQLADAFRQDWITAMIRETRSN 850 Query: 838 QLFSQATKDTARWAREQQKRQLS 860 + F T +TARWAREQ KRQ++ Sbjct: 851 REFGARTIETARWAREQVKRQIA 873 >2Q5D-A nrPDB Length = 876 Score = 464 bits (1195), Expect = e-131, Method: Compositional matrix adjust. Identities = 297/879 (33%), Positives = 471/879 (53%), Gaps = 35/879 (3%) Query: 5 EFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRILAALT 64 E +LE ++ SPD+ ++ L++ + +N F S+VL + R+ A L Sbjct: 2 ELITILEKTV-SPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQ 60 Query: 65 LKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIAD 124 +KN L SKD Q+ QRW+ + A+ ++K L L E ++A+Q +A IA Sbjct: 61 IKNSLTSKDPDIKAQYQQRWLA-IDANARREVKNYVLQTL-GTETYRPSSASQCVAGIAC 118 Query: 125 IELPHGAWPELMKIMVDN-TGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNILIA 183 E+P WPEL+ +V N T E++K ++L A+GY+C+ DP+ L SN IL A Sbjct: 119 AEIPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQ--LQDKSNEILTA 176 Query: 184 IVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAA 243 I+QG + E S V+LAA NAL +SL F K N ++E ER+++MQVVCEATQ D V+ A Sbjct: 177 IIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVA 236 Query: 244 AFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAY- 302 A L KIMSLYY +M+ YM AL+A+TI MKS D+VA +EFWS +C+EE+D+A Sbjct: 237 ALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIE 296 Query: 303 --ELAQFPQSPLQSYNF-ALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFA 359 E A+ + P + F A +++ +VP L LT+Q+E+ +DDDWN +AG CL L A Sbjct: 297 ASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLA 356 Query: 360 QNCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNL 419 C + I+ VL F++++I +WR R+AAVMAFG I++GP+ Q V QA+P+++ L Sbjct: 357 TCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIEL 416 Query: 420 MNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIIN 479 M D S+ V++T AW +GRI + + E+ +L ++Q + GL P+VA+N W + Sbjct: 417 MKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSS 476 Query: 480 LVEQLAEAT--------PSP--IYNFYPALVDGLIGAANRID-NEFNARASAFSALTTMV 528 L E EA P+ + + + +V L+ +R D ++ N R+SA+ +L +V Sbjct: 477 LAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIV 536 Query: 529 EYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRK-S 587 + + + +M++L Q + ++ + + D +LQS + L V+RK Sbjct: 537 KNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQ 596 Query: 588 PSSVEPVADMLMGLFFRLLEKK-DSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLK 646 ++D++M R+ + S +++D A+S L LG F KY+E F P+L Sbjct: 597 HQDALQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGI 656 Query: 647 AL-NQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSV 705 L N + V + AVG + D+ +L+ + + D +M +L + + N N R +KP +LSV Sbjct: 657 GLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSV 716 Query: 706 FGDIASNIGADFIPYLNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGL 765 FGDIA IG +F YL ++ A + + + +DY ++ E+ L+AY GIV GL Sbjct: 717 FGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGL 776 Query: 766 HDKPEALF-------PYVGTIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSI 818 E + P V I FI +A D D A GLIGD+ F + Sbjct: 777 KGDQENVHPDVMLVQPRVEFILSFIDHIAGDED--HTDGVVACAAGLIGDLCTAFGKDVL 834 Query: 819 KQFYGQDWVIDYIKRTRSGQLFSQATKDTARWAREQQKR 857 K + + + + R + + K A WA ++ ++ Sbjct: 835 KLVEARPMIHELLTEGRRSK--TNKAKTLATWATKELRK 871 >2QNA-A nrPDB Length = 762 Score = 417 bits (1072), Expect = e-117, Method: Compositional matrix adjust. Identities = 259/751 (34%), Positives = 408/751 (54%), Gaps = 32/751 (4%) Query: 133 PELMKIMVDN-TGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNILIAIVQGAQST 191 PEL+ +V N T E++K ++L A+GY+C+ DP+ L SN IL AI+QG + Sbjct: 2 PELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQ--LQDKSNEILTAIIQGMRKE 59 Query: 192 ETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGCLCKI 251 E S V+LAA NAL +SL F K N ++E ER+++MQVVCEATQ D V+ AA L KI Sbjct: 60 EPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQNLVKI 119 Query: 252 MSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAY---ELAQFP 308 MSLYY +M+ YM AL+A+TI MKS D+VA +EFWS +C+EE+D+A E A+ Sbjct: 120 MSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQG 179 Query: 309 QSPLQSYNF-ALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGNHIL 367 + P + F A +++ +VP L LT+Q+E+ +DDDWN +AG CL L A C + I+ Sbjct: 180 RPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIV 239 Query: 368 EPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQV 427 VL F++++I +WR R+AAVMAFG I++GP+ Q V QA+P+++ LM D S+ V Sbjct: 240 PHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVV 299 Query: 428 KETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEA 487 ++T AW +GRI + + E+ +L ++Q + GL P+VA+N W +L E EA Sbjct: 300 RDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEA 359 Query: 488 T--------PSP--IYNFYPALVDGLIGAANRID-NEFNARASAFSALTTMVEYATDTVA 536 P+ + + + +V L+ +R D ++ N R+SA+ +L +V+ + Sbjct: 360 ADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCY 419 Query: 537 ETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRK-SPSSVEPVA 595 + +M++L Q + ++ + + D +LQS + L V+RK ++ Sbjct: 420 PAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQIS 479 Query: 596 DMLMGLFFRLLEKK-DSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKAL-NQVDS 653 D++M R+ + S +++D A+S L LG F KY+E F P+L L N + Sbjct: 480 DVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEY 539 Query: 654 PVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNI 713 V + AVG + D+ +L+ + + D +M +L + + N N R +KP +LSVFGDIA I Sbjct: 540 QVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIALAI 599 Query: 714 GADFIPYLNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALF 773 G +F YL ++ A + + + +DY ++ E+ L+AY GIV GL E + Sbjct: 600 GGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVH 659 Query: 774 -------PYVGTIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDW 826 P V I FI +A D D A GLIGD+ F +K + Sbjct: 660 PDVMLVQPRVEFILSFIDHIAGDED--HTDGVVACAAGLIGDLCTAFGKDVLKLVEARPM 717 Query: 827 VIDYIKRTRSGQLFSQATKDTARWAREQQKR 857 + + + R + + K A WA ++ ++ Sbjct: 718 IHELLTEGRRSK--TNKAKTLATWATKELRK 746 >1M5N-S nrPDB Length = 485 Score = 329 bits (843), Expect = 4e-90, Method: Compositional matrix adjust. Identities = 195/488 (39%), Positives = 291/488 (59%), Gaps = 10/488 (2%) Query: 5 EFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRILAALT 64 E +LE ++ SPD+ ++ L++ + +N F S+VL + R+ A L Sbjct: 2 ELITILEKTV-SPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQ 60 Query: 65 LKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIAD 124 +KN L SKD Q+ QRW+ + A+ ++K L L E ++A+Q +A IA Sbjct: 61 IKNSLTSKDPDIKAQYQQRWLA-IDANARREVKNYVLQTL-GTETYRPSSASQCVAGIAC 118 Query: 125 IELPHGAWPELMKIMVDN-TGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNILIA 183 E+P WPEL+ +V N T E++K ++L A+GY+C+ DP+ L SN IL A Sbjct: 119 AEIPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQ--LQDKSNEILTA 176 Query: 184 IVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAA 243 I+QG + E S V+LAA NAL +SL F K N ++E ER+++MQVVCEATQ D V+ A Sbjct: 177 IIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVA 236 Query: 244 AFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAY- 302 A L KIMSLYY +M+ YM AL+A+TI MKS D+VA +EFWS +C+EE+D+A Sbjct: 237 ALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIE 296 Query: 303 --ELAQFPQSPLQSYNF-ALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFA 359 E A+ + P + F A +++ +VP L LT+Q+E+ +DDDWN +AG CL L A Sbjct: 297 ASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLA 356 Query: 360 QNCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNL 419 C + I+ VL F++++I +WR R+AAVMAFG I++GP+ Q V QA+P+++ L Sbjct: 357 TCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIEL 416 Query: 420 MNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIIN 479 M D S+ V++T AW +GRI + + E+ +L ++Q + GL P+VA+N W + Sbjct: 417 MKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSS 476 Query: 480 LVEQLAEA 487 L E EA Sbjct: 477 LAEAAYEA 484 >4B8J-A nrPDB Length = 528 Score = 34.3 bits (77), Expect = 0.21, Method: Compositional matrix adjust. Identities = 29/114 (25%), Positives = 46/114 (40%), Gaps = 8/114 (7%) Query: 389 AVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDP 448 A A +I G + + H A+P + L+ S V+E W +G +A + D Sbjct: 138 AAWALTNIASGTSENTKVVIDHGAVPIFVKLLGSSSDDVREQAVWALGNVAGDSPKCRD- 196 Query: 449 QQHLPGVVQACLIGLQDHPKVA--TNCSWTIINLVEQLAEATPSPIY-NFYPAL 499 G + L L +H K++ N +WT+ N P P + PAL Sbjct: 197 LVLANGALLPLLAQLNEHTKLSMLRNATWTLSN----FCRGKPQPSFEQTRPAL 246 Score = 32.0 bits (71), Expect = 1.2, Method: Compositional matrix adjust. Identities = 23/76 (30%), Positives = 37/76 (48%), Gaps = 9/76 (11%) Query: 389 AVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQ--VKETTAWCIGRIADSVAESI 446 A+ G+I+ G D + HQALP +L+L+ Q+L+ +K+ W I I + I Sbjct: 306 ALRTVGNIVTGDDAQTQCIIDHQALPCLLSLLT-QNLKKSIKKEACWTISNITAGNKDQI 364 Query: 447 DPQQHLPGVVQACLIG 462 V+ A +IG Sbjct: 365 Q------AVINAGIIG 374 >4B8O-A nrPDB Length = 490 Score = 33.9 bits (76), Expect = 0.34, Method: Compositional matrix adjust. Identities = 29/114 (25%), Positives = 46/114 (40%), Gaps = 8/114 (7%) Query: 389 AVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDP 448 A A +I G + + H A+P + L+ S V+E W +G +A + D Sbjct: 100 AAWALTNIASGTSENTKVVIDHGAVPIFVKLLGSSSDDVREQAVWALGNVAGDSPKCRD- 158 Query: 449 QQHLPGVVQACLIGLQDHPKVAT--NCSWTIINLVEQLAEATPSPIY-NFYPAL 499 G + L L +H K++ N +WT+ N P P + PAL Sbjct: 159 LVLANGALLPLLAQLNEHTKLSMLRNATWTLSN----FCRGKPQPSFEQTRPAL 208 Score = 31.6 bits (70), Expect = 1.5, Method: Compositional matrix adjust. Identities = 23/76 (30%), Positives = 37/76 (48%), Gaps = 9/76 (11%) Query: 389 AVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQ--VKETTAWCIGRIADSVAESI 446 A+ G+I+ G D + HQALP +L+L+ Q+L+ +K+ W I I + I Sbjct: 268 ALRTVGNIVTGDDAQTQCIIDHQALPCLLSLLT-QNLKKSIKKEACWTISNITAGNKDQI 326 Query: 447 DPQQHLPGVVQACLIG 462 V+ A +IG Sbjct: 327 Q------AVINAGIIG 336 >3GNN-A nrPDB Length = 298 Score = 33.1 bits (74), Expect = 0.52, Method: Compositional matrix adjust. Identities = 30/97 (30%), Positives = 46/97 (47%), Gaps = 10/97 (10%) Query: 362 CGNHILEPVLEFVEQNITADNWRNREAAVMAFGSI---MDGPDKVQRTYYVHQALPSILN 418 CG + V+ V+ +I D WR+RE M+ S + GP + T A + LN Sbjct: 70 CGVPWFDAVVRAVDPSIEVD-WRHREGDRMSADSTVCELRGPARALLT-----AERNALN 123 Query: 419 LMNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGV 455 + S V T + RIAD+ A +D ++ LPG+ Sbjct: 124 FLQLLS-GVASATRQYVDRIADTRARILDTRKTLPGL 159 >4ILH-B nrPDB Length = 339 Score = 32.0 bits (71), Expect = 1.3, Method: Compositional matrix adjust. Identities = 31/103 (30%), Positives = 48/103 (46%), Gaps = 7/103 (6%) Query: 494 NFYPAL--VDGLIGAANRIDN-EFNARASAFSALTTMVEYATDTVAETSASISTFV-MDK 549 NFY DGL D +F F MV Y +T +++ FV MDK Sbjct: 66 NFYIQYDPKDGLYKMMEERDGAKFENIVHNFKERQMMVSYPKIDEDDTWYNLTEFVQMDK 125 Query: 550 LGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVE 592 + + + DENQ + D+ S+ +Q N L L + ++K+ S +E Sbjct: 126 IRKIVRKDENQFSYVDS-SMTTVQENEL--LKSSLQKAGSKME 165 >4I43-A nrPDB Length = 384 Score = 31.6 bits (70), Expect = 1.6, Method: Compositional matrix adjust. Identities = 28/94 (29%), Positives = 45/94 (47%), Gaps = 5/94 (5%) Query: 501 DGLIGAANRIDN-EFNARASAFSALTTMVEYATDTVAETSASISTFV-MDKLGQTMSVDE 558 DGL D +F F MV Y +T +++ FV MDK+ + + DE Sbjct: 75 DGLYKMMEERDGAKFENIVHNFKERQMMVSYPKIDEDDTWYNLTEFVQMDKIRKIVRKDE 134 Query: 559 NQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVE 592 NQ + D+ S+ +Q N L L + ++K+ S +E Sbjct: 135 NQFSYVDS-SMTTVQENEL--LKSSLQKAGSKME 165 >1WA5-B nrPDB Length = 530 Score = 30.4 bits (67), Expect = 3.2, Method: Compositional matrix adjust. Identities = 24/95 (25%), Positives = 42/95 (44%), Gaps = 6/95 (6%) Query: 389 AVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDP 448 A A +I G + A+P + L+ S++VKE W +G +A +S D Sbjct: 151 AAWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVA---GDSTDY 207 Query: 449 QQH-LPGVVQACLIGL--QDHPKVATNCSWTIINL 480 + + L ++GL + P + +WT+ NL Sbjct: 208 RDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNL 242 >6BQN-B nrPDB Length = 495 Score = 30.4 bits (67), Expect = 3.4, Method: Compositional matrix adjust. Identities = 17/56 (30%), Positives = 26/56 (46%) Query: 600 GLFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDSPV 655 G+ L E++ FI D+ YA+S S+G +K PY +N + PV Sbjct: 268 GVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPV 323 >4A4Z-A nrPDB Length = 997 Score = 30.4 bits (67), Expect = 3.5, Method: Compositional matrix adjust. Identities = 17/60 (28%), Positives = 30/60 (50%) Query: 677 YSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPYLNDIMALCVAAQNTKP 736 Y +A +N++ +M+ +P+ LK L F D + F+ ++ A+CV TKP Sbjct: 588 YKEATVNLMQEMVKSPSILHILKEGRLVAFRDPNDCLKLGFVFKVSLKDAVCVIMTFTKP 647 >5VQI-B nrPDB Length = 495 Score = 30.4 bits (67), Expect = 3.7, Method: Compositional matrix adjust. Identities = 26/91 (28%), Positives = 39/91 (42%), Gaps = 7/91 (7%) Query: 412 ALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVA- 470 A+P + L+ V+E W +G IA + D G ++ L L D K++ Sbjct: 114 AVPIFVELLGSPEPDVREQAVWALGNIAGDSPQCRDYVLSC-GALRPLLTLLGDSRKLSM 172 Query: 471 -TNCSWTIINLVEQLAEATPSPIYN-FYPAL 499 N +WT+ N TP P +N PAL Sbjct: 173 LRNATWTLSNFCRG---KTPQPDWNTIAPAL 200 >1UN0-A nrPDB Length = 443 Score = 30.0 bits (66), Expect = 4.7, Method: Compositional matrix adjust. Identities = 24/95 (25%), Positives = 42/95 (44%), Gaps = 6/95 (6%) Query: 389 AVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDP 448 A A +I G + A+P + L+ S++VKE W +G +A +S D Sbjct: 64 AAWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVA---GDSTDY 120 Query: 449 QQH-LPGVVQACLIGL--QDHPKVATNCSWTIINL 480 + + L ++GL + P + +WT+ NL Sbjct: 121 RDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNL 155 >1PYP-A nrPDB Length = 285 Score = 29.3 bits (64), Expect = 6.8, Method: Composition-based stats. Identities = 21/84 (25%), Positives = 34/84 (40%), Gaps = 6/84 (7%) Query: 520 AFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTV 579 AFS +YA D + ET S + K + +D +TL D + + S+ Sbjct: 203 AFSGEAKNKKYALDIIKETHNSWKQLIAGKSSDSKGIDLTNVTLPDTPTYSKAASD---- 258 Query: 580 LAAVIRKSPSSVEPVADMLMGLFF 603 A+ SP + P+ + FF Sbjct: 259 --AIPPASPKADAPIDKSIDKWFF 280 >4AKX-B nrPDB Length = 660 Score = 29.3 bits (64), Expect = 7.4, Method: Compositional matrix adjust. Identities = 29/109 (26%), Positives = 48/109 (44%), Gaps = 17/109 (15%) Query: 610 DSAFIEDDVFYAISA-LAASLGKGFEKYLETFSPYLLKALNQVDSPVSITAVGFIADISN 668 DS+ + +F IS+ + ASL KG + FS LL L ++DS + Sbjct: 147 DSSNKKLKLFQHISSEIGASLKKGLGNKIGGFSELLLNVLPRIDSRAE--------PLER 198 Query: 669 SLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADF 717 L ++ R+ VL Q+ ++P R+ P V ++ + S G F Sbjct: 199 LLRDETRKA------VLGQIATHPEVARQ--PTVAAIASRLQSGSGVTF 239 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2Q5D-A nrPDB 1280 0.0 5OWU-A nrPDB 1235 0.0 4XRI-A nrPDB 1171 0.0 2QNA-A nrPDB 1110 0.0 1M5N-S nrPDB 765 0.0 Sequences not found previously or not previously below threshold: 2OT8-A nrPDB 147 2e-35 1WA5-B nrPDB 50 6e-06 1UN0-A nrPDB 47 3e-05 4P6Z-B nrPDB 42 0.001 4UAD-A nrPDB 42 0.001 4UQI-B nrPDB 41 0.003 2PF4-A nrPDB 40 0.003 4TNM-A nrPDB 39 0.008 5VQI-B nrPDB 39 0.009 3TJ3-A nrPDB 38 0.015 4B8O-A nrPDB 37 0.034 5D08-A nrPDB 37 0.038 4B8J-A nrPDB 37 0.039 3IFQ-A nrPDB 36 0.071 4E4V-A nrPDB 35 0.15 1IAL-A nrPDB 35 0.17 5V5P-C nrPDB 35 0.19 2Z6G-A nrPDB 34 0.35 2Z6H-A nrPDB 33 0.45 5TBK-A nrPDB 33 0.52 6BVV-A nrPDB 33 0.72 2GL7-A nrPDB 32 0.76 2C6Q-A nrPDB 32 0.90 3C5W-A nrPDB 32 1.1 5UE7-A nrPDB 32 1.5 2BWG-A nrPDB 32 1.5 4LAC-A nrPDB 32 1.6 1XYZ-A nrPDB 31 1.9 2X19-B nrPDB 29 7.6 >2Q5D-A nrPDB Length = 876 Score = 1280 bits (3312), Expect = 0.0, Method: Composition-based stats. Identities = 297/879 (33%), Positives = 471/879 (53%), Gaps = 35/879 (3%) Query: 5 EFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRILAALT 64 E +LE ++ SPD+ ++ L++ + +N F S+VL + R+ A L Sbjct: 2 ELITILEKTV-SPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQ 60 Query: 65 LKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIAD 124 +KN L SKD Q+ QRW+ + A+ ++K L L E ++A+Q +A IA Sbjct: 61 IKNSLTSKDPDIKAQYQQRWLA-IDANARREVKNYVLQTL-GTETYRPSSASQCVAGIAC 118 Query: 125 IELPHGAWPELMKIMVDN-TGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNILIA 183 E+P WPEL+ +V N T E++K ++L A+GY+C+ DP+ L SN IL A Sbjct: 119 AEIPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQ--LQDKSNEILTA 176 Query: 184 IVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAA 243 I+QG + E S V+LAA NAL +SL F K N ++E ER+++MQVVCEATQ D V+ A Sbjct: 177 IIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVA 236 Query: 244 AFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYE 303 A L KIMSLYY +M+ YM AL+A+TI MKS D+VA +EFWS +C+EE+D+A E Sbjct: 237 ALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIE 296 Query: 304 L---AQFPQSPLQSYNF-ALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFA 359 A+ + P + F A +++ +VP L LT+Q+E+ +DDDWN +AG CL L A Sbjct: 297 ASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLA 356 Query: 360 QNCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNL 419 C + I+ VL F++++I +WR R+AAVMAFG I++GP+ Q V QA+P+++ L Sbjct: 357 TCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIEL 416 Query: 420 MNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIIN 479 M D S+ V++T AW +GRI + + E+ +L ++Q + GL P+VA+N W + Sbjct: 417 MKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSS 476 Query: 480 LVEQLAEAT--------PSP--IYNFYPALVDGLIGAANRID-NEFNARASAFSALTTMV 528 L E EA P+ + + + +V L+ +R D ++ N R+SA+ +L +V Sbjct: 477 LAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIV 536 Query: 529 EYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRK-S 587 + + + +M++L Q + ++ + + D +LQS + L V+RK Sbjct: 537 KNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQ 596 Query: 588 PSSVEPVADMLMGLFFRLLEKK-DSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLK 646 ++D++M R+ + S +++D A+S L LG F KY+E F P+L Sbjct: 597 HQDALQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGI 656 Query: 647 AL-NQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSV 705 L N + V + AVG + D+ +L+ + + D +M +L + + N N R +KP +LSV Sbjct: 657 GLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSV 716 Query: 706 FGDIASNIGADFIPYLNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGL 765 FGDIA IG +F YL ++ A + + + +DY ++ E+ L+AY GIV GL Sbjct: 717 FGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGL 776 Query: 766 HDKPEALF-------PYVGTIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSI 818 E + P V I FI +A D D A GLIGD+ F + Sbjct: 777 KGDQENVHPDVMLVQPRVEFILSFIDHIAGDED--HTDGVVACAAGLIGDLCTAFGKDVL 834 Query: 819 KQFYGQDWVIDYIKRTRSGQLFSQATKDTARWAREQQKR 857 K + + + + R + + K A WA ++ ++ Sbjct: 835 KLVEARPMIHELLTEGRRSK--TNKAKTLATWATKELRK 871 >5OWU-A nrPDB Length = 861 Score = 1235 bits (3195), Expect = 0.0, Method: Composition-based stats. Identities = 861/861 (100%), Positives = 861/861 (100%) Query: 1 MSTAEFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRIL 60 MSTAEFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRIL Sbjct: 1 MSTAEFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRIL 60 Query: 61 AALTLKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIA 120 AALTLKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIA Sbjct: 61 AALTLKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIA 120 Query: 121 AIADIELPHGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNI 180 AIADIELPHGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNI Sbjct: 121 AIADIELPHGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNI 180 Query: 181 LIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEV 240 LIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEV Sbjct: 181 LIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEV 240 Query: 241 QAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDI 300 QAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDI Sbjct: 241 QAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDI 300 Query: 301 AYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQ 360 AYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQ Sbjct: 301 AYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQ 360 Query: 361 NCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLM 420 NCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLM Sbjct: 361 NCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLM 420 Query: 421 NDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINL 480 NDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINL Sbjct: 421 NDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINL 480 Query: 481 VEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSA 540 VEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSA Sbjct: 481 VEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSA 540 Query: 541 SISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMG 600 SISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMG Sbjct: 541 SISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMG 600 Query: 601 LFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDSPVSITAV 660 LFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDSPVSITAV Sbjct: 601 LFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDSPVSITAV 660 Query: 661 GFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPY 720 GFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPY Sbjct: 661 GFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPY 720 Query: 721 LNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIF 780 LNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIF Sbjct: 721 LNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIF 780 Query: 781 QFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSGQLF 840 QFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSGQLF Sbjct: 781 QFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSGQLF 840 Query: 841 SQATKDTARWAREQQKRQLSL 861 SQATKDTARWAREQQKRQLSL Sbjct: 841 SQATKDTARWAREQQKRQLSL 861 >4XRI-A nrPDB Length = 882 Score = 1171 bits (3030), Expect = 0.0, Method: Composition-based stats. Identities = 342/863 (39%), Positives = 524/863 (60%), Gaps = 15/863 (1%) Query: 9 LLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRILAALTLKNE 68 +LENS LSPD +R +E QL + NF Q+ Q L +E+++ R A + LKN Sbjct: 15 ILENS-LSPDATLRHAAEQQLTHAAETNFSQYLLTLVQALANESSEGHIRAAAGIALKNA 73 Query: 69 LVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIADIELP 128 +++ + +W+ Q E + ++K AL L S + AAAQ+IAAIA IELP Sbjct: 74 FSAREFARQAALQAKWLNQTDQETRTRVKQLALETLASPNSKAGQAAAQVIAAIAAIELP 133 Query: 129 HGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESADPQ-SQALVSSSNNILIAIVQG 187 WPELM +V N +E ++ K+ASL A+G++CE+ D +LV SN IL A+VQG Sbjct: 134 RNQWPELMHALVRN-ASEGGQHQKQASLTAIGFICETQDTDLRNSLVGHSNAILTAVVQG 192 Query: 188 AQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGC 247 A+ E + VR AA+ AL DSL F+ NN + EGERNY+MQVVCEATQA+D +Q AFGC Sbjct: 193 ARKEEPNNEVRFAAITALGDSLEFVGNNFKHEGERNYIMQVVCEATQAQDSRIQQGAFGC 252 Query: 248 LCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQF 307 L +IM+LYY M+ YME+AL+ LTI MKS ++ VA + VEFWST+CEEEI I + AQ Sbjct: 253 LNRIMALYYEHMRYYMEKALFGLTILGMKSDDEDVAKLAVEFWSTVCEEEIAIEDDNAQV 312 Query: 308 PQSPLQS--YNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGNH 365 S YNFA + +VVP LL LLT+Q+ED DD++N+S +A CLQL+AQ G+ Sbjct: 313 ESSEQMRPFYNFARVATNEVVPVLLQLLTKQDEDASDDEYNISRAAYQCLQLYAQAVGST 372 Query: 366 ILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSL 425 I+ PV++FVE N+ +W R+AAV AFG+IMDGP++ V + ++ +M D+S+ Sbjct: 373 IIPPVIQFVEHNLRHADWHFRDAAVSAFGAIMDGPEEKVLEPIVKTGMQPLIAMMEDESI 432 Query: 426 QVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLA 485 QV+++TA+ +GRI ++ +E+IDP HL ++++ GL + PK+A +C W ++N+ E+ A Sbjct: 433 QVRDSTAYALGRITEACSEAIDPNTHLEPLIRSLFNGLMNSPKMAASCCWALMNIAERFA 492 Query: 486 ---EATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASI 542 A +P+ + V L+ ++ + R +A+ L+ V+ A + AS+ Sbjct: 493 GEPGAAQNPLTPHFNQSVTNLLTVTAPMNGDSTVRTAAYEVLSVFVQNAANDSLSAVASL 552 Query: 543 STFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMGLF 602 ST ++ +L +T+ + + +++ED L+++Q+++ TVL A +++ + P D +M + Sbjct: 553 STVILQRLEETLPLQQQVVSVEDKLILEDMQTSLCTVLQATVQRLDKEIAPQGDRIMQVL 612 Query: 603 FRLLEK-KDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKAL-NQVDSPVSITAV 660 ++L + + + VF AISALA ++ + F KY+E F+P+L AL NQ + + A+ Sbjct: 613 LQILSTCGGKSSVPEGVFAAISALANAMEEEFAKYMEAFAPFLYNALGNQEEPSLCSMAI 672 Query: 661 GFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPY 720 G ++D++ SL E + Y D MN L + + + KPA+L FGDIAS IG F Y Sbjct: 673 GLVSDVTRSLGERSQPYCDNFMNYLLGNLRSTTLANQFKPAILQCFGDIASAIGGHFETY 732 Query: 721 LNDI-MALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLH--DKPEALFPYVG 777 L + L AA T +G+ E +DY I + E ++DA+ GI+ + +K L PYV Sbjct: 733 LTIVAQVLQQAATITAGPDGSYEMIDYVISLREGIMDAWGGIIGAMKTSNKTNVLQPYVE 792 Query: 778 TIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSG 837 +IF + +A DP +A RA++G+IGD+A +P+G + + QDW+ I+ TRS Sbjct: 793 SIFALLNSIANDPN--RSEALMRASMGVIGDLADAYPNGQLADAFRQDWITAMIRETRSN 850 Query: 838 QLFSQATKDTARWAREQQKRQLS 860 + F T +TARWAREQ KRQ++ Sbjct: 851 REFGARTIETARWAREQVKRQIA 873 >2QNA-A nrPDB Length = 762 Score = 1110 bits (2870), Expect = 0.0, Method: Composition-based stats. Identities = 259/751 (34%), Positives = 408/751 (54%), Gaps = 32/751 (4%) Query: 133 PELMKIMVDN-TGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNILIAIVQGAQST 191 PEL+ +V N T E++K ++L A+GY+C+ DP+ L SN IL AI+QG + Sbjct: 2 PELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQ--LQDKSNEILTAIIQGMRKE 59 Query: 192 ETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGCLCKI 251 E S V+LAA NAL +SL F K N ++E ER+++MQVVCEATQ D V+ AA L KI Sbjct: 60 EPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQNLVKI 119 Query: 252 MSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYEL---AQFP 308 MSLYY +M+ YM AL+A+TI MKS D+VA +EFWS +C+EE+D+A E A+ Sbjct: 120 MSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQG 179 Query: 309 QSPLQSYNF-ALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGNHIL 367 + P + F A +++ +VP L LT+Q+E+ +DDDWN +AG CL L A C + I+ Sbjct: 180 RPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIV 239 Query: 368 EPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQV 427 VL F++++I +WR R+AAVMAFG I++GP+ Q V QA+P+++ LM D S+ V Sbjct: 240 PHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVV 299 Query: 428 KETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEA 487 ++T AW +GRI + + E+ +L ++Q + GL P+VA+N W +L E EA Sbjct: 300 RDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEA 359 Query: 488 T--------PSP--IYNFYPALVDGLIGAANRID-NEFNARASAFSALTTMVEYATDTVA 536 P+ + + + +V L+ +R D ++ N R+SA+ +L +V+ + Sbjct: 360 ADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCY 419 Query: 537 ETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRK-SPSSVEPVA 595 + +M++L Q + ++ + + D +LQS + L V+RK ++ Sbjct: 420 PAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQIS 479 Query: 596 DMLMGLFFRLLEKK-DSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKAL-NQVDS 653 D++M R+ + S +++D A+S L LG F KY+E F P+L L N + Sbjct: 480 DVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEY 539 Query: 654 PVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNI 713 V + AVG + D+ +L+ + + D +M +L + + N N R +KP +LSVFGDIA I Sbjct: 540 QVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIALAI 599 Query: 714 GADFIPYLNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALF 773 G +F YL ++ A + + + +DY ++ E+ L+AY GIV GL E + Sbjct: 600 GGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVH 659 Query: 774 -------PYVGTIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDW 826 P V I FI +A D D A GLIGD+ F +K + Sbjct: 660 PDVMLVQPRVEFILSFIDHIAGDED--HTDGVVACAAGLIGDLCTAFGKDVLKLVEARPM 717 Query: 827 VIDYIKRTRSGQLFSQATKDTARWAREQQKR 857 + + + R + + K A WA ++ ++ Sbjct: 718 IHELLTEGRRSK--TNKAKTLATWATKELRK 746 >1M5N-S nrPDB Length = 485 Score = 765 bits (1974), Expect = 0.0, Method: Composition-based stats. Identities = 195/489 (39%), Positives = 291/489 (59%), Gaps = 10/489 (2%) Query: 5 EFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRILAALT 64 E +LE ++ SPD+ ++ L++ + +N F S+VL + R+ A L Sbjct: 2 ELITILEKTV-SPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQ 60 Query: 65 LKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIAD 124 +KN L SKD Q+ QRW+ + A+ ++K L L E ++A+Q +A IA Sbjct: 61 IKNSLTSKDPDIKAQYQQRWLA-IDANARREVKNYVLQTL-GTETYRPSSASQCVAGIAC 118 Query: 125 IELPHGAWPELMKIMVDN-TGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNILIA 183 E+P WPEL+ +V N T E++K ++L A+GY+C+ DP+ L SN IL A Sbjct: 119 AEIPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQ--LQDKSNEILTA 176 Query: 184 IVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAA 243 I+QG + E S V+LAA NAL +SL F K N ++E ER+++MQVVCEATQ D V+ A Sbjct: 177 IIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVA 236 Query: 244 AFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYE 303 A L KIMSLYY +M+ YM AL+A+TI MKS D+VA +EFWS +C+EE+D+A E Sbjct: 237 ALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIE 296 Query: 304 L---AQFPQSPLQSYNF-ALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFA 359 A+ + P + F A +++ +VP L LT+Q+E+ +DDDWN +AG CL L A Sbjct: 297 ASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLA 356 Query: 360 QNCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNL 419 C + I+ VL F++++I +WR R+AAVMAFG I++GP+ Q V QA+P+++ L Sbjct: 357 TCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIEL 416 Query: 420 MNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIIN 479 M D S+ V++T AW +GRI + + E+ +L ++Q + GL P+VA+N W + Sbjct: 417 MKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSS 476 Query: 480 LVEQLAEAT 488 L E EA Sbjct: 477 LAEAAYEAA 485 >2OT8-A nrPDB Length = 852 Score = 147 bits (371), Expect = 2e-35, Method: Composition-based stats. Identities = 134/752 (17%), Positives = 261/752 (34%), Gaps = 86/752 (11%) Query: 12 NSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLE-GRILAALTLKNELV 70 SPD I+ T + +L++L + + F VL ++ E R L+ L LKN Sbjct: 20 KESQSPDTTIQRTVQQKLEQL--NQYPDFNNYLIFVLTKLKSEDEPTRSLSGLILKNN-- 75 Query: 71 SKDSVKTQQFAQRWITQVSPEAKNQ-IKTNALTALVSIEPRIANAAAQLIAAIADIELPH 129 F P IK+ L + P I LI IA Sbjct: 76 -----VKAHFQNF------PNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGELQ 124 Query: 130 GAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESADP--QSQALVSSSNNILIAIVQG 187 WP+L+ + +E N + AL +CE + S L N ++ +Q Sbjct: 125 N-WPDLLPKLCSLLDSED-YNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQF 182 Query: 188 AQSTETS---------KAVRLAALNALADSLI-FIKNNMEREGERNYLMQVVCEATQAED 237 + + ++ AL + FI+N G+ E+ Sbjct: 183 FKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGD--------------EE 228 Query: 238 IEVQAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEE 297 EV+ L ++ + + P+M + + + ++ VA EFW T+ E+ Sbjct: 229 PEVRKNVCRALVMLLEVRMDRLLPHMHN-IVEYMLQRTQDQDENVALEACEFWLTLAEQP 287 Query: 298 IDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQL 357 I + P+ N S D++ ++ D DWN+ + A L + Sbjct: 288 ICKDVLVRHLPKLIPVLVNGMKYSDIDIILLKGDVEGGSGGDDTISDWNLRKCSAAALDV 347 Query: 358 FAQNCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSIL 417 A + +L +L +++ + W +E+ ++ G+I +G + Y+ + +P ++ Sbjct: 348 LANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMI-PYLPELIPHLI 406 Query: 418 NLMNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDH-PKVATNCSWT 476 ++D+ V+ T W + R A V S P +L ++ L + D +V Sbjct: 407 QCLSDKKALVRSITCWTLSRYAHWVV-SQPPDTYLKPLMTELLKRILDSNKRVQEAACSA 465 Query: 477 IINLVEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVA 536 L E+ + + + ++D L+ A ++ ++ L + D+V Sbjct: 466 FATLEEEAC----TELVPYLAYILDTLVFAFSKYQHKNLL------ILYDAIGTLADSVG 515 Query: 537 ETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVAD 596 M L + N L ED +L L++V S P + Sbjct: 516 HHLNKPEYIQM--LMPPLIQKWNMLKDEDKDLFP-----LLECLSSVATALQSGFLPYCE 568 Query: 597 MLMGLFFRLLEKK-----------DSAFIEDDVFYAI-----SALAASLGKGFEKYL--E 638 + L++K D D F + S LA LG E+ + Sbjct: 569 PVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLVARS 628 Query: 639 TFSPYLLKALNQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARREL 698 + + + V ++ + D++ + + + M +L ++ + Sbjct: 629 NILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFI--SV 686 Query: 699 KPAVLSVFGDIASNIGADFIPYLNDIMALCVA 730 G+I+ +G + PY+ ++ V Sbjct: 687 CNNATWAIGEISIQMGIEMQPYIPMVLHQLVE 718 Score = 32.0 bits (71), Expect = 1.2, Method: Composition-based stats. Identities = 30/147 (20%), Positives = 55/147 (37%), Gaps = 12/147 (8%) Query: 331 NLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGNHILEPV---LEFVEQNITADNWRNRE 387 N+LT + +D V S+ A L + C H+ + + + N+ + Sbjct: 629 NILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFISVCN 688 Query: 388 AAVMAFG--SIMDGPDKVQRTYYVHQALPSILNLMNDQSL--QVKETTAWCIGRIADSVA 443 A A G SI G + Y+ L ++ ++N + + E TA IGR+ Sbjct: 689 NATWAIGEISIQMGIE---MQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCP 745 Query: 444 ESIDP--QQHLPGVVQACLIGLQDHPK 468 + + P QQ + + + K Sbjct: 746 QEVAPMLQQFIRPWCTSLRNIRDNEEK 772 >1WA5-B nrPDB Length = 530 Score = 49.7 bits (117), Expect = 6e-06, Method: Composition-based stats. Identities = 59/334 (17%), Positives = 117/334 (35%), Gaps = 49/334 (14%) Query: 366 ILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSL 425 ++ ++EF+ +N EAA A +I G + A+P + L+ S+ Sbjct: 131 VVPRLVEFMREN--QPEMLQLEAA-WALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSV 187 Query: 426 QVKETTAWCIGRIADSVAESIDPQQHLPGVVQA----CLIGL--QDHPKVATNCSWTIIN 479 +VKE W +G + + D + V+Q ++GL + P + +WT+ N Sbjct: 188 EVKEQAIWALGNV------AGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSN 241 Query: 480 LVEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETS 539 L P P ++ + L +D E A + Y +D E Sbjct: 242 LCR---GKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACW------AISYLSDGPQEAI 292 Query: 540 ASISTF-VMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADML 598 ++ + +L + +S + + Q+ L + ++ + + V + Sbjct: 293 QAVIDVRIPKRLVELLSHESTLV-----------QTPALRAVGNIVTGNDLQTQVVINAG 341 Query: 599 MGLFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLET-FSPYLLKALNQVDSPVSI 657 + RLL I+ + + IS + A + + ++ P L+K L + Sbjct: 342 VLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEYKTKK 401 Query: 658 TAVGFIA----------DISNSLEED--FRRYSD 679 A I+ DI L + D Sbjct: 402 EACWAISNASSGGLQRPDIIRYLVSQGCIKPLCD 435 >1UN0-A nrPDB Length = 443 Score = 47.4 bits (111), Expect = 3e-05, Method: Composition-based stats. Identities = 59/334 (17%), Positives = 117/334 (35%), Gaps = 49/334 (14%) Query: 366 ILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSL 425 ++ ++EF+ +N EAA A +I G + A+P + L+ S+ Sbjct: 44 VVPRLVEFMREN--QPEMLQLEAA-WALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSV 100 Query: 426 QVKETTAWCIGRIADSVAESIDPQQHLPGVVQA----CLIGL--QDHPKVATNCSWTIIN 479 +VKE W +G + + D + V+Q ++GL + P + +WT+ N Sbjct: 101 EVKEQAIWALGNV------AGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSN 154 Query: 480 LVEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETS 539 L P P ++ + L +D E A + Y +D E Sbjct: 155 LCR---GKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACW------AISYLSDGPQEAI 205 Query: 540 ASISTF-VMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADML 598 ++ + +L + +S + + Q+ L + ++ + + V + Sbjct: 206 QAVIDVRIPKRLVELLSHESTLV-----------QTPALRAVGNIVTGNDLQTQVVINAG 254 Query: 599 MGLFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLET-FSPYLLKALNQVDSPVSI 657 + RLL I+ + + IS + A + + ++ P L+K L + Sbjct: 255 VLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEDKTKK 314 Query: 658 TAVGFIA----------DISNSLEED--FRRYSD 679 A I+ DI L + D Sbjct: 315 EACWAISNASSGGLQRPDIIRYLVSQGCIKPLCD 348 >4P6Z-B nrPDB Length = 600 Score = 42.0 bits (97), Expect = 0.001, Method: Composition-based stats. Identities = 30/166 (18%), Positives = 59/166 (35%), Gaps = 14/166 (8%) Query: 343 DDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDK 402 D+ + L +A++ + + V FV+ N R AV G I Sbjct: 77 DNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKD-CEDPNPLIRALAVRTMGCI------ 129 Query: 403 VQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIG 462 + + + D+ V++T A C+ ++ D A+ ++ Q L + Sbjct: 130 -RVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISD- 187 Query: 463 LQDHPKVATNCSWTIINLVEQLAEATPSPIYNFYPALVDGLIGAAN 508 +P V N + + E S + + P ++ L+ A N Sbjct: 188 --SNPMVVANAVAALSEIAES---HPSSNLLDLNPQSINKLLTALN 228 >4UAD-A nrPDB Length = 479 Score = 41.6 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 36/185 (19%), Positives = 67/185 (36%), Gaps = 16/185 (8%) Query: 310 SPLQSYNFALSSIKDVVPNLLNLLTRQNEDP-EDDDWNVSMSAGACLQLFAQNCGNHILE 368 P FA S +P L LL + D D W +S + + + + Sbjct: 187 PPE----FAKVS--PCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCR 240 Query: 369 PVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVK 428 ++E + N +++ A+ A G+I+ G D + ALP +L+L++ ++ Sbjct: 241 RLVELLMHN----DYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIR 296 Query: 429 ETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQ-DHPKVATNCSWTIINLVEQLAEA 487 + W I I + + + + LQ + +W I N + Sbjct: 297 KEACWTISNIT-AGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITN---ATSGG 352 Query: 488 TPSPI 492 TP I Sbjct: 353 TPEQI 357 Score = 39.0 bits (89), Expect = 0.010, Method: Composition-based stats. Identities = 26/113 (23%), Positives = 42/113 (37%), Gaps = 9/113 (7%) Query: 373 FVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQA--LPSILNLMNDQSLQVKET 430 FVE +N + A A +I G Q+T V +A +P + L+N V+E Sbjct: 72 FVEFLKRNENCTLQFEAAWALTNIASG--TSQQTKIVIEAGAVPIFIELLNSDFEDVQEQ 129 Query: 431 TAWCIGRIA---DSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINL 480 W +G IA + + L ++ + N W + NL Sbjct: 130 AVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTK--STRLTMTRNAVWALSNL 180 >4UQI-B nrPDB Length = 657 Score = 40.9 bits (94), Expect = 0.003, Method: Composition-based stats. Identities = 30/166 (18%), Positives = 59/166 (35%), Gaps = 14/166 (8%) Query: 343 DDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDK 402 D+ + L +A++ + + V FV+ N R AV G I Sbjct: 61 DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKD-CEDPNPLIRALAVRTMGCI------ 113 Query: 403 VQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIG 462 + + + D+ V++T A C+ ++ D A+ ++ Q L + Sbjct: 114 -RVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIAD- 171 Query: 463 LQDHPKVATNCSWTIINLVEQLAEATPSPIYNFYPALVDGLIGAAN 508 +P V N + + E S + + P ++ L+ A N Sbjct: 172 --SNPMVVANAVAALSEISESHPN---SNLLDLNPQNINKLLTALN 212 >2PF4-A nrPDB Length = 589 Score = 40.5 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 69/491 (14%), Positives = 159/491 (32%), Gaps = 72/491 (14%) Query: 370 VLEFVEQNITADNWRNREAA--VMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQV 427 +L F+ I ++ A + F +++ GP+ YVH LP + +L + V Sbjct: 51 LLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPE------YVHCLLPPLESLATVEETVV 104 Query: 428 KETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEA 487 ++ + I+ + S D + H +V+ G + T+ +++ A Sbjct: 105 RDKAVESLRAISHEHSPS-DLEAHFVPLVKRLAGGDWFTSR--TSACGLFSVCYPRVSSA 161 Query: 488 TPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVM 547 + + ++ L D+ R +A S L + ++ Sbjct: 162 VKAELRQYFRNLCS---------DDTPMVRRAAASKLGEFAKVLELDNVKS--------- 203 Query: 548 DKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMGLFFRLLE 607 + + + N + ++ S++ L +A ++ + +M + E Sbjct: 204 ----EIIPMFSNLAS-DEQDSVRLLAVEACVNIAQLLPQEDLEAL-----VMPTLRQAAE 253 Query: 608 KKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDSPVSITAVGFIADIS 667 K S + V + L ++G K P + ++ V A + + Sbjct: 254 DK-SWRVRYMVADKFTELQKAVGPEITK--TDLVPAFQNLMKDCEAEVRAAASHKVKEFC 310 Query: 668 NSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPYLNDIMAL 727 + +S + +L ++ S+ L ++ Sbjct: 311 -------------------ENLSADCRENVIMTQILPCIKELVSDANQHVKSALASVIMG 351 Query: 728 CVAAQNTKPENGTLEAL--DYQIKVLEAVLDAYVGIVAGLHDKPEALFPY--VGTIFQFI 783 ++ T+E L + ++ + + + I++ L E + ++ I Sbjct: 352 L---SPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAI 408 Query: 784 AQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDY---IKRTRSGQLF 840 ++AED + A L G + F D + W++D+ I+ + L Sbjct: 409 VELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSL-CMAWLVDHVYAIREAATSNLK 467 Query: 841 SQATKDTARWA 851 K WA Sbjct: 468 KLVEKFGKEWA 478 Score = 37.8 bits (86), Expect = 0.022, Method: Composition-based stats. Identities = 34/256 (13%), Positives = 86/256 (33%), Gaps = 19/256 (7%) Query: 288 EFWSTICEEEIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNV 347 +++ +C ++ + A + +++P NL + ++ D Sbjct: 168 QYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLAS------DEQDSVR 221 Query: 348 SMSAGACLQLFAQNCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTY 407 ++ AC+ + + V+ + Q +WR R F + Sbjct: 222 LLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITK- 280 Query: 408 YVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHP 467 +P+ NLM D +V+ + + ++++ + ++ + D Sbjct: 281 --TDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMTQILPCIKELVSDAN 338 Query: 468 KVATNCSWTII----------NLVEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNAR 517 + + ++I N +E L + + + P + +I + ++ R Sbjct: 339 QHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIR 398 Query: 518 ASAFSALTTMVEYATD 533 + S L +VE A D Sbjct: 399 QLSQSLLPAIVELAED 414 Score = 31.2 bits (69), Expect = 1.8, Method: Composition-based stats. Identities = 38/213 (17%), Positives = 84/213 (39%), Gaps = 36/213 (16%) Query: 323 KDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQNITA-- 380 + ++P ++ L ED W V ++ + L A G +EF ++ + + Sbjct: 402 QSLLPAIVEL-------AEDAKWRVRLAIIEYMPLLAGQLG-------VEFFDEKLNSLC 447 Query: 381 ------DNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWC 434 + REAA ++ +K + + +P +L + D + + TT +C Sbjct: 448 MAWLVDHVYAIREAATSNLKKLV---EKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFC 504 Query: 435 IGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEATPSPIYN 494 I +++ + I + LP V++ + P N + N+ + L + P + Sbjct: 505 INVLSEVCGQDITTKHMLPTVLR-----MAGDP--VANVRF---NVAKSLQKIGPILDNS 554 Query: 495 FYPALVDGLIGAANRIDNEFNARASAFSALTTM 527 + V ++ + D + + + A ALT + Sbjct: 555 TLQSEVKPILEKLTQ-DQDVDVKYFAQEALTVL 586 >4TNM-A nrPDB Length = 531 Score = 39.0 bits (89), Expect = 0.008, Method: Composition-based stats. Identities = 40/289 (13%), Positives = 93/289 (32%), Gaps = 43/289 (14%) Query: 362 CGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMN 421 + ++ V++F+ D + + A A +I G + A+P + L++ Sbjct: 115 VQSGVVPRVVKFLS---RDDFPKLQFEAAWALTNIASGTSENTNVIIESGAVPIFIQLLS 171 Query: 422 DQSLQVKETTAWCIGRIA---DSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTII 478 S V+E W +G +A + + + ++ + + N +WT+ Sbjct: 172 SASEDVREQAVWALGNVAGDSPKCRDLVLSYGAMTPLLSQFNENTKLS--MLRNATWTLS 229 Query: 479 NLVEQ----LAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDT 534 N E T P LV + + A AL+ + + + + Sbjct: 230 NFCRGKPPPAFEQTQ-PALPVLERLVQSM---------DEEVLTDACWALSYLSDNS-ND 278 Query: 535 VAETSASISTF--VMDKLGQTMS--VDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSS 590 + ++ LG + + T+ + + +LQ+ ++ Sbjct: 279 KIQAVIEAGVVPRLIQLLGHSSPSVLIPALRTIGNIVTGDDLQTQMV---------LDQQ 329 Query: 591 VEPVADMLMGLFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLET 639 P LL+ I+ + + IS + A + ++ Sbjct: 330 ALP-------CLLNLLKNNYKKSIKKEACWTISNITAGNADQIQAVIDA 371 >5VQI-B nrPDB Length = 495 Score = 39.0 bits (89), Expect = 0.009, Method: Composition-based stats. Identities = 28/134 (20%), Positives = 50/134 (37%), Gaps = 14/134 (10%) Query: 368 EPVLEFVE--------QNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNL 419 P+ E ++ + + + + + A A +I G + A+P + L Sbjct: 62 PPIEEVIKTGVVGRFVEFLRSPHTLVQFEAAWALTNIASGSATQTQVVIEAGAVPIFVEL 121 Query: 420 MNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVA--TNCSWTI 477 + V+E W +G IA + D G ++ L L D K++ N +WT+ Sbjct: 122 LGSPEPDVREQAVWALGNIAGDSPQCRD-YVLSCGALRPLLTLLGDSRKLSMLRNATWTL 180 Query: 478 INLVEQLAEATPSP 491 N TP P Sbjct: 181 SNFCR---GKTPQP 191 Score = 30.9 bits (68), Expect = 2.6, Method: Composition-based stats. Identities = 66/417 (15%), Positives = 130/417 (31%), Gaps = 58/417 (13%) Query: 174 VSSSNNILIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEAT 233 S + L +V+G S+E K ++ A L +N E + ++ E Sbjct: 23 ESQLSEDLPKMVEGVFSSEIDKQIQ--ATTKFRKLLSKERNPPIEEVIKTGVVGRFVEFL 80 Query: 234 QAEDIEVQAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTI 293 ++ VQ A L I S T + +E + + + SP V V I Sbjct: 81 RSPHTLVQFEAAWALTNIASGSATQTQVVIEAGAVPIFVELLGSPEPDVREQAVWALGNI 140 Query: 294 CEEEIDIAYELAQFPQ-SPLQS------------------YNFALSSIKD--------VV 326 + + PL + NF + Sbjct: 141 AGDSPQCRDYVLSCGALRPLLTLLGDSRKLSMLRNATWTLSNFCRGKTPQPDWNTIAPAL 200 Query: 327 PNLLNLL-TRQNEDPEDDDWNVSMSAGACLQLFAQNCGNHILEPVLEF-----VEQNITA 380 P L L+ + +E D W +S + + N ++ V+E + + + Sbjct: 201 PVLAKLVYSLDDEVLIDACWAIS---------YLSDGSNDKIQAVIEAGIPRRLVELLMH 251 Query: 381 DNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIA- 439 + + A+ + G+I+ G D + ALP +L+L++ +++ W I I Sbjct: 252 ASTSVQTPALRSVGNIVTGDDVQTQVIINCGALPCLLSLLSSNKDGIRKEACWTISNITA 311 Query: 440 --DSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEATPSPIYNFYP 497 + +S+ +P ++ K W I N + Y Sbjct: 312 GNSAQIQSVIDANIIPPLIHLLSH---ADLKTRKEACWAISNATSGGLQKPDQIRYLVAQ 368 Query: 498 ALVDGLIGAANRIDNEFNARASAFSALTTMV------EYATDTVAETSASISTFVMD 548 + L DN+ A L ++ + A ++ + F+ + Sbjct: 369 GCIKPLCDLLACPDNK--IIQVALDGLENILKVGELDKNAAGDGPDSINRYALFIEE 423 >3TJ3-A nrPDB Length = 447 Score = 38.2 bits (87), Expect = 0.015, Method: Composition-based stats. Identities = 23/94 (24%), Positives = 39/94 (41%), Gaps = 10/94 (10%) Query: 403 VQRTYYVHQA--LPSILNLMNDQSLQVKETTAWCIGRIA---DSVAESIDPQQHLPGVVQ 457 +T V QA +P + L++ + V+E W +G IA + + LP ++Q Sbjct: 94 SLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQ 153 Query: 458 ACLIGLQDHPKVATNCSWTIINLVEQLAEATPSP 491 L Q+ + N W + NL +P P Sbjct: 154 --LFSKQNRLTMTRNAVWALSNLCR---GKSPPP 182 >4B8O-A nrPDB Length = 490 Score = 37.0 bits (84), Expect = 0.034, Method: Composition-based stats. Identities = 36/181 (19%), Positives = 66/181 (36%), Gaps = 15/181 (8%) Query: 362 CGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMN 421 + ++ ++F+ D + + A A +I G + + H A+P + L+ Sbjct: 76 IQSGVVPRFVQFLT---REDFPQLQFEAAWALTNIASGTSENTKVVIDHGAVPIFVKLLG 132 Query: 422 DQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVA--TNCSWTIIN 479 S V+E W +G +A + D G + L L +H K++ N +WT+ N Sbjct: 133 SSSDDVREQAVWALGNVAGDSPKCRD-LVLANGALLPLLAQLNEHTKLSMLRNATWTLSN 191 Query: 480 LVEQLAEATPSPIYNFYPALVDGLIGAANRI-DNEFNARASAFSALTTMVEYATDTVAET 538 P P + L A I N+ A AL+ + T+ + Sbjct: 192 ----FCRGKPQP---SFEQTRPALPALARLIHSNDEEVLTDACWALS-YLSDGTNDKIQA 243 Query: 539 S 539 Sbjct: 244 V 244 Score = 33.6 bits (75), Expect = 0.44, Method: Composition-based stats. Identities = 30/177 (16%), Positives = 59/177 (33%), Gaps = 19/177 (10%) Query: 315 YNFALSS-------IKDVVPNLLNLLTRQNEDP-EDDDWNVSMSAGACLQLFAQNCGNHI 366 NF + +P L L+ +E+ D W +S + + Sbjct: 190 SNFCRGKPQPSFEQTRPALPALARLIHSNDEEVLTDACWALSYLSDGTNDKIQAVIEAGV 249 Query: 367 LEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLM-NDQSL 425 ++E + + A+ G+I+ G D + HQALP +L+L+ + Sbjct: 250 CPRLVEL----LLHPSPSVLIPALRTVGNIVTGDDAQTQCIIDHQALPCLLSLLTQNLKK 305 Query: 426 QVKETTAWCIGRIA---DSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIIN 479 +K+ W I I +++ + +V + +W I N Sbjct: 306 SIKKEACWTISNITAGNKDQIQAVINAGIIGPLVNLL---QTAEFDIKKEAAWAISN 359 >5D08-A nrPDB Length = 437 Score = 37.0 bits (84), Expect = 0.038, Method: Composition-based stats. Identities = 16/50 (32%), Positives = 22/50 (44%), Gaps = 8/50 (16%) Query: 399 GPDKVQRTYYVH-------QALPSILNLM-NDQSLQVKETTAWCIGRIAD 440 G +QR + ALP + LM D ++ T AW IG+I D Sbjct: 324 GKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRGTAAWAIGKIGD 373 >4B8J-A nrPDB Length = 528 Score = 37.0 bits (84), Expect = 0.039, Method: Composition-based stats. Identities = 36/181 (19%), Positives = 66/181 (36%), Gaps = 15/181 (8%) Query: 362 CGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMN 421 + ++ ++F+ D + + A A +I G + + H A+P + L+ Sbjct: 114 IQSGVVPRFVQFLT---REDFPQLQFEAAWALTNIASGTSENTKVVIDHGAVPIFVKLLG 170 Query: 422 DQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVA--TNCSWTIIN 479 S V+E W +G +A + D G + L L +H K++ N +WT+ N Sbjct: 171 SSSDDVREQAVWALGNVAGDSPKCRD-LVLANGALLPLLAQLNEHTKLSMLRNATWTLSN 229 Query: 480 LVEQLAEATPSPIYNFYPALVDGLIGAANRI-DNEFNARASAFSALTTMVEYATDTVAET 538 P P + L A I N+ A AL+ + T+ + Sbjct: 230 ----FCRGKPQP---SFEQTRPALPALARLIHSNDEEVLTDACWALS-YLSDGTNDKIQA 281 Query: 539 S 539 Sbjct: 282 V 282 Score = 33.9 bits (76), Expect = 0.27, Method: Composition-based stats. Identities = 53/338 (15%), Positives = 107/338 (31%), Gaps = 41/338 (12%) Query: 174 VSSSNNILIAIVQGAQSTETSKAVRLAALNALADSLIFIKNN-MEREGERNYLMQVVCEA 232 V L A++ G S + ++L A L ++ +E + + + V Sbjct: 69 VDKKLESLPAMIGGVYSDD--NNLQLEATTQFRKLLSIERSPPIEEVIQSGVVPRFVQFL 126 Query: 233 TQAEDIEVQAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWST 292 T+ + ++Q A L I S K ++ + + + S +D V V Sbjct: 127 TREDFPQLQFEAAWALTNIASGTSENTKVVIDHGAVPIFVKLLGSSSDDVREQAVWALGN 186 Query: 293 ICEEE---IDIAYELAQF----PQSPLQS------------YNFALSS-------IKDVV 326 + + D+ Q + NF + + Sbjct: 187 VAGDSPKCRDLVLANGALLPLLAQLNEHTKLSMLRNATWTLSNFCRGKPQPSFEQTRPAL 246 Query: 327 PNLLNLLTRQNEDP-EDDDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQNITADNWRN 385 P L L+ +E+ D W +S + + ++E + + Sbjct: 247 PALARLIHSNDEEVLTDACWALSYLSDGTNDKIQAVIEAGVCPRLVEL----LLHPSPSV 302 Query: 386 REAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLM-NDQSLQVKETTAWCIGRIA---DS 441 A+ G+I+ G D + HQALP +L+L+ + +K+ W I I Sbjct: 303 LIPALRTVGNIVTGDDAQTQCIIDHQALPCLLSLLTQNLKKSIKKEACWTISNITAGNKD 362 Query: 442 VAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIIN 479 +++ + +V + +W I N Sbjct: 363 QIQAVINAGIIGPLVNLL---QTAEFDIKKEAAWAISN 397 >3IFQ-A nrPDB Length = 553 Score = 35.9 bits (81), Expect = 0.071, Method: Composition-based stats. Identities = 25/139 (17%), Positives = 51/139 (36%), Gaps = 14/139 (10%) Query: 399 GPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVA--ESIDPQQHLPGVV 456 G + + + +++ +M + S E W R+ ++ S P G + Sbjct: 175 GNQESKLIILANGGPQALVQIMRNYSY---EKLLWTTSRVLKVLSVCPSNKPAIVEAGGM 231 Query: 457 QACLIGL-QDHPKVATNCSWTIINLVEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFN 515 QA L + P++ NC WT+ NL + + + + LV+ L ++ N Sbjct: 232 QALGKHLTSNSPRLVQNCLWTLRNLSDVATK--QEGLESVLKILVNQLSV------DDVN 283 Query: 516 ARASAFSALTTMVEYATDT 534 A L+ + + Sbjct: 284 VLTCATGTLSNLTCNNSKN 302 >4E4V-A nrPDB Length = 485 Score = 35.1 bits (79), Expect = 0.15, Method: Composition-based stats. Identities = 44/289 (15%), Positives = 100/289 (34%), Gaps = 39/289 (13%) Query: 392 AFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIA---DSVAESIDP 448 A +I G + + A+P+ ++L+ + E W +G IA + + Sbjct: 99 ALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIK 158 Query: 449 QQHLPGVVQACLIGLQDHPKVAT-------NCSWTIINLVEQLAEATPSPIYNFYPALVD 501 + ++ L P +++ N +WT+ NL P+P + ++ Sbjct: 159 YGAVDPLL-----ALLAVPDMSSLACGYLRNLTWTLSNLCR---NKNPAPPIDAVEQILP 210 Query: 502 GLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMS--VDEN 559 L+ + D E DT + ++ +++G + V Sbjct: 211 TLVRLLHHDDPEV----------------LADTCW-AISYLTDGPNERIGMVVKTGVVPQ 253 Query: 560 QLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMGLFFRLLEKKDSAFIEDDVF 619 + L A L + + L + ++ + + V D F L I+ + Sbjct: 254 LVKLLGASEL-PIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEAT 312 Query: 620 YAISALAASLGKGFEKYL-ETFSPYLLKALNQVDSPVSITAVGFIADIS 667 + +S + A ++ + P+L+ L++ D AV + + + Sbjct: 313 WTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYT 361 Score = 30.9 bits (68), Expect = 2.4, Method: Composition-based stats. Identities = 39/267 (14%), Positives = 87/267 (32%), Gaps = 19/267 (7%) Query: 365 HILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQS 424 +E +L + + + D+ A + DGP++ +P ++ L+ Sbjct: 203 DAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASE 262 Query: 425 LQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPK--VATNCSWTIINLV- 481 L + IG I E Q + A L +PK + +WT+ N+ Sbjct: 263 LPIVTPALRAIGNIVTGTDEQT--QVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITA 320 Query: 482 ---EQLAEATPSPIYNFYPALVDG---------LIGAANRIDNEFNARASAFSALTTMVE 529 +Q+ + + F +++ + N + ++E Sbjct: 321 GRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSG-GTVEQIVYLVHCGIIE 379 Query: 530 YATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPS 589 + + I ++D + E E S+ + L + A+ Sbjct: 380 PLMNLLTAKDTKIILVILDAISNIFQAAEKLGETE-KLSIMIEECGGLDKIEALQNHENE 438 Query: 590 SVEPVADMLMGLFFRLLEKKDSAFIED 616 SV + L+ +F + E++D + + Sbjct: 439 SVYRASLSLIEKYFSVEEEEDQNVVPE 465 >1IAL-A nrPDB Length = 453 Score = 34.7 bits (78), Expect = 0.17, Method: Composition-based stats. Identities = 40/276 (14%), Positives = 95/276 (34%), Gaps = 39/276 (14%) Query: 392 AFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIA---DSVAESIDP 448 A +I G + + A+P+ ++L+ + E W +G IA + + + Sbjct: 100 ALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIK 159 Query: 449 QQHLPGVVQACLIGLQDHPKVAT-------NCSWTIINLVEQLAEATPSPIYNFYPALVD 501 + ++ L P ++T N +WT+ NL P+P + ++ Sbjct: 160 HGAIDPLL-----ALLAVPDLSTLACGYLRNLTWTLSNLCR---NKNPAPPLDAVEQILP 211 Query: 502 GLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMS--VDEN 559 L+ R+ + + A + ++ +++ + V Sbjct: 212 TLV----RLLHHNDPEVLA-------------DSCWAISYLTDGPNERIEMVVKKGVVPQ 254 Query: 560 QLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMGLFFRLLEKKDSAFIEDDVF 619 + L A L + + L + ++ + + V D F L I+ + Sbjct: 255 LVKLLGATEL-PIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEAT 313 Query: 620 YAISALAASLGKGFEKYL-ETFSPYLLKALNQVDSP 654 + +S + A ++ + P+L+ L++ D Sbjct: 314 WTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFK 349 >5V5P-C nrPDB Length = 528 Score = 34.7 bits (78), Expect = 0.19, Method: Composition-based stats. Identities = 40/276 (14%), Positives = 95/276 (34%), Gaps = 39/276 (14%) Query: 392 AFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIA---DSVAESIDP 448 A +I G + + A+P+ ++L+ + E W +G IA + + + Sbjct: 142 ALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIK 201 Query: 449 QQHLPGVVQACLIGLQDHPKVAT-------NCSWTIINLVEQLAEATPSPIYNFYPALVD 501 + ++ L P ++T N +WT+ NL P+P + ++ Sbjct: 202 HGAIDPLL-----ALLAVPDLSTLACGYLRNLTWTLSNLCR---NKNPAPPLDAVEQILP 253 Query: 502 GLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMS--VDEN 559 L+ R+ + + A + ++ +++ + V Sbjct: 254 TLV----RLLHHNDPEVLA-------------DSCWAISYLTDGPNERIEMVVKKGVVPQ 296 Query: 560 QLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMGLFFRLLEKKDSAFIEDDVF 619 + L A L + + L + ++ + + V D F L I+ + Sbjct: 297 LVKLLGATEL-PIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEAT 355 Query: 620 YAISALAASLGKGFEKYL-ETFSPYLLKALNQVDSP 654 + +S + A ++ + P+L+ L++ D Sbjct: 356 WTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFK 391 Score = 30.9 bits (68), Expect = 2.5, Method: Composition-based stats. Identities = 37/266 (13%), Positives = 88/266 (33%), Gaps = 17/266 (6%) Query: 365 HILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQS 424 +E +L + + + ++ + A + DGP++ +P ++ L+ Sbjct: 246 DAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATE 305 Query: 425 LQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPK--VATNCSWTIINLVE 482 L + IG I E + A L +PK + +WT+ N+ Sbjct: 306 LPIVTPALRAIGNIVTGTDEQTQKVIDAGAL--AVFPSLLTNPKTNIQKEATWTMSNITA 363 Query: 483 QLAEATPSPIYNFYPALVDGLIGAANRIDNEF------------NARASAFSALTTMVEY 530 + + + + G++ A+ + + ++E Sbjct: 364 GRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEP 423 Query: 531 ATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSS 590 + ++ I ++D + E E S+ + L + A+ R S Sbjct: 424 LMNLLSAKDTKIIQVILDAISNIFQAAEKLGETE-KLSIMIEECGGLDKIEALQRHENES 482 Query: 591 VEPVADMLMGLFFRLLEKKDSAFIED 616 V + L+ +F + E++D + + Sbjct: 483 VYKASLNLIEKYFSVEEEEDQNVVPE 508 >2Z6G-A nrPDB Length = 780 Score = 33.6 bits (75), Expect = 0.35, Method: Composition-based stats. Identities = 33/205 (16%), Positives = 67/205 (32%), Gaps = 29/205 (14%) Query: 399 GPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVA--ESIDPQQHLPGVV 456 G + + +++N+M + E W R+ ++ S P G + Sbjct: 306 GNQESKLIILASGGPQALVNIMRTYTY---EKLLWTTSRVLKVLSVCSSNKPAIVEAGGM 362 Query: 457 QACLIGLQD-HPKVATNCSWTIINLVEQLAEATPSPIYNFYPALVDGLIGAANRI--DNE 513 QA + L D ++ NC WT+ NL + + ++GL+G ++ ++ Sbjct: 363 QALGLHLTDPSQRLVQNCLWTLRNLSDAATK----------QEGMEGLLGTLVQLLGSDD 412 Query: 514 FNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQ 573 N A L+ + +G ++ L D + + E Sbjct: 413 INVVTCAAGILSNLTCNNYKNKMMVCQ---------VGGIEALVRTVLRAGDREDITE-- 461 Query: 574 SNILTVLAAVIRKSPSSVEPVADML 598 I + R + + A L Sbjct: 462 PAICALRHLTSRHQDAEMAQNAVRL 486 >2Z6H-A nrPDB Length = 644 Score = 33.2 bits (74), Expect = 0.45, Method: Composition-based stats. Identities = 33/205 (16%), Positives = 67/205 (32%), Gaps = 29/205 (14%) Query: 399 GPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVA--ESIDPQQHLPGVV 456 G + + +++N+M + E W R+ ++ S P G + Sbjct: 170 GNQESKLIILASGGPQALVNIMRTYTY---EKLLWTTSRVLKVLSVCSSNKPAIVEAGGM 226 Query: 457 QACLIGLQD-HPKVATNCSWTIINLVEQLAEATPSPIYNFYPALVDGLIGAANRI--DNE 513 QA + L D ++ NC WT+ NL + + ++GL+G ++ ++ Sbjct: 227 QALGLHLTDPSQRLVQNCLWTLRNLSDAATK----------QEGMEGLLGTLVQLLGSDD 276 Query: 514 FNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQ 573 N A L+ + +G ++ L D + + E Sbjct: 277 INVVTCAAGILSNLTCNNYKNKMMVCQ---------VGGIEALVRTVLRAGDREDITE-- 325 Query: 574 SNILTVLAAVIRKSPSSVEPVADML 598 I + R + + A L Sbjct: 326 PAICALRHLTSRHQEAEMAQNAVRL 350 >5TBK-A nrPDB Length = 521 Score = 33.2 bits (74), Expect = 0.52, Method: Composition-based stats. Identities = 73/427 (17%), Positives = 140/427 (32%), Gaps = 72/427 (16%) Query: 222 RNYLMQVVCEATQAE-DIEVQAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPND 280 RN + +CE + + D VQ + + + S ++ QA L + P D Sbjct: 49 RNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPID 108 Query: 281 KVASMTVEFWSTICEE---------EIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLN 331 + + C E E A S ++ VP L Sbjct: 109 DLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNA----VPLFLR 164 Query: 332 LLTRQNEDP-EDDDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQNI-----TADNWRN 385 LL +++ E W + G Q +++P+L F+ +I W Sbjct: 165 LLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTW-- 222 Query: 386 REAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAES 445 VM P T + + LP++ L++ + + T W + + D+ E Sbjct: 223 ----VMVNLCRHKDPPPPMET--IQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQ 276 Query: 446 IDPQQ------HLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEATPSPIY----NF 495 I HL ++ KV T + N+V E T + + Sbjct: 277 IQMVIDSGIVPHLVPLLS------HQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSH 330 Query: 496 YPALVDGLIGAANR----------IDNEFNARASAFSALTTMVEYATDTVAETSASISTF 545 +PAL+ N+ N+ +A + L M+ + D + + + Sbjct: 331 FPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAW 390 Query: 546 VMDKL--------------GQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSV 591 + L + N LT++DAQ +Q +L L+ +++ + Sbjct: 391 AISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQ----VVLDGLSNILKMAEDEA 446 Query: 592 EPVADML 598 E + +++ Sbjct: 447 ETIGNLI 453 Score = 31.6 bits (70), Expect = 1.4, Method: Composition-based stats. Identities = 28/124 (22%), Positives = 52/124 (41%), Gaps = 15/124 (12%) Query: 378 ITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCI-- 435 +T + + AV +I G + + +P I++L++ ++ AW I Sbjct: 335 LTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISN 394 Query: 436 ----GR---IADSVAESIDP------QQHLPGVVQACLIGLQDHPKVATNCSWTIINLVE 482 GR +A + +++ P VVQ L GL + K+A + + TI NL+E Sbjct: 395 LTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIE 454 Query: 483 QLAE 486 + Sbjct: 455 ECGG 458 >6BVV-A nrPDB Length = 459 Score = 32.8 bits (73), Expect = 0.72, Method: Composition-based stats. Identities = 31/154 (20%), Positives = 58/154 (37%), Gaps = 15/154 (9%) Query: 338 EDPEDDDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQNI---------TADNWRNREA 388 ++ D+ + +SA +Q + + P+ + ++ I DN + Sbjct: 16 QNASSDNQGIQLSA---VQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFE 72 Query: 389 AVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDP 448 A A +I G + + A+P L L++ V E W +G I + D Sbjct: 73 AAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDY 132 Query: 449 QQHLPGVVQACLIGLQDHPKVA--TNCSWTIINL 480 L GVV+ L + + N +W ++NL Sbjct: 133 VISL-GVVKPLLSFISPSIPITFLRNVTWVMVNL 165 Score = 31.6 bits (70), Expect = 1.6, Method: Composition-based stats. Identities = 28/124 (22%), Positives = 52/124 (41%), Gaps = 15/124 (12%) Query: 378 ITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCI-- 435 +T + + AV +I G + + +P I++L++ ++ AW I Sbjct: 273 LTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISN 332 Query: 436 ----GR---IADSVAESIDP------QQHLPGVVQACLIGLQDHPKVATNCSWTIINLVE 482 GR +A + +++ P VVQ L GL + K+A + + TI NL+E Sbjct: 333 LTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIE 392 Query: 483 QLAE 486 + Sbjct: 393 ECGG 396 Score = 30.5 bits (67), Expect = 3.2, Method: Composition-based stats. Identities = 69/411 (16%), Positives = 132/411 (32%), Gaps = 71/411 (17%) Query: 237 DIEVQAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEE 296 D VQ + + + S ++ QA L + P D + + C E Sbjct: 3 DYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLE 62 Query: 297 ---------EIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDP-EDDDWN 346 E A S ++ VP L LL +++ E W Sbjct: 63 RDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNA----VPLFLRLLHSPHQNVCEQAVWA 118 Query: 347 VSMSAGACLQLFAQNCGNHILEPVLEFVEQNI-----TADNWRNREAAVMAFGSIMDGPD 401 + G Q +++P+L F+ +I W VM P Sbjct: 119 LGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTW------VMVNLCRHKDPP 172 Query: 402 KVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQ------HLPGV 455 T + + LP++ L++ + + T W + + D+ E I HL + Sbjct: 173 PPMET--IQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPL 230 Query: 456 VQACLIGLQDHPKVATNCSWTIINLVEQLAEATPSPIY----NFYPALVDGLIGAANR-- 509 + KV T + N+V E T + + +PAL+ N+ Sbjct: 231 LS------HQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEA 284 Query: 510 --------IDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKL----------- 550 N+ +A + L M+ + D + + + + L Sbjct: 285 VWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAY 344 Query: 551 ---GQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADML 598 + N LT++DAQ +Q +L L+ +++ + E + +++ Sbjct: 345 LIQQNVIPPFCNLLTVKDAQVVQ----VVLDGLSNILKMAEDEAETIGNLI 391 >2GL7-A nrPDB Length = 550 Score = 32.4 bits (72), Expect = 0.76, Method: Composition-based stats. Identities = 33/205 (16%), Positives = 67/205 (32%), Gaps = 29/205 (14%) Query: 399 GPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVA--ESIDPQQHLPGVV 456 G + + +++N+M + E W R+ ++ S P G + Sbjct: 171 GNQESKLIILASGGPQALVNIMRTYTY---EKLLWTTSRVLKVLSVCSSNKPAIVEAGGM 227 Query: 457 QACLIGLQD-HPKVATNCSWTIINLVEQLAEATPSPIYNFYPALVDGLIGAANRI--DNE 513 QA + L D ++ NC WT+ NL + + ++GL+G ++ ++ Sbjct: 228 QALGLHLTDPSQRLVQNCLWTLRNLSDAATK----------QEGMEGLLGTLVQLLGSDD 277 Query: 514 FNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQ 573 N A L+ + +G ++ L D + + E Sbjct: 278 INVVTCAAGILSNLTCNNYKNKMMVCQ---------VGGIEALVRTVLRAGDREDITE-- 326 Query: 574 SNILTVLAAVIRKSPSSVEPVADML 598 I + R + + A L Sbjct: 327 PAICALRHLTSRHQEAEMAQNAVRL 351 >2C6Q-A nrPDB Length = 351 Score = 32.4 bits (72), Expect = 0.90, Method: Composition-based stats. Identities = 19/120 (15%), Positives = 37/120 (30%), Gaps = 6/120 (5%) Query: 700 PAVLSVFGDIASNIGADFIPYLNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYV 759 P V + D+A+ F+ ++ D+ T E ++ I ++ + Sbjct: 131 PQVKYICLDVANGYSEHFVEFVKDVRKRFPQHTIMAGNVVTGEMVEELILSGADIIKVGI 190 Query: 760 --GIVAGLHDKPEALFPYVGTIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGS 817 G V K +P + + + D GD+A F G+ Sbjct: 191 GPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIISDGGCSCP----GDVAKAFGAGA 246 >3C5W-A nrPDB Length = 232 Score = 32.0 bits (71), Expect = 1.1, Method: Composition-based stats. Identities = 38/213 (17%), Positives = 84/213 (39%), Gaps = 36/213 (16%) Query: 323 KDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQNITA-- 380 + ++P ++ L ED W V ++ + L A G +EF ++ + + Sbjct: 45 QSLLPAIVEL-------AEDAKWRVRLAIIEYMPLLAGQLG-------VEFFDEKLNSLC 90 Query: 381 ------DNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWC 434 + REAA ++ +K + + +P +L + D + + TT +C Sbjct: 91 MAWLVDHVYAIREAATSNLKKLV---EKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFC 147 Query: 435 IGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEATPSPIYN 494 I +++ + I + LP V++ + P N + N+ + L + P + Sbjct: 148 INVLSEVCGQDITTKHMLPTVLR-----MAGDP--VANVRF---NVAKSLQKIGPILDNS 197 Query: 495 FYPALVDGLIGAANRIDNEFNARASAFSALTTM 527 + V ++ + D + + + A ALT + Sbjct: 198 TLQSEVKPILEKLTQ-DQDVDVKYFAQEALTVL 229 >5UE7-A nrPDB Length = 252 Score = 31.6 bits (70), Expect = 1.5, Method: Composition-based stats. Identities = 27/130 (20%), Positives = 48/130 (36%), Gaps = 17/130 (13%) Query: 630 GKGFEKYLETFSPYLLKALNQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMI 689 G K +E P +L + S +TA +++ S + +N I Sbjct: 50 GSDLSKQVEQLGPNVLNDFDYCFSENGLTAYKLGKELA----------SQSFINW----I 95 Query: 690 SNPNARRELKPAVLSVFGDIASNIG-ADFIPYLNDIMALCVAAQNTKP-ENGTLEALDYQ 747 N + +K +L DI I FI + N ++ + +N E E D Q Sbjct: 96 GNEKYNKLVK-FILRYLSDIDLPIRRGTFIEFRNGMINVSPIGRNASTQERNDYEKFDKQ 154 Query: 748 IKVLEAVLDA 757 + E +++A Sbjct: 155 HHIRETMVEA 164 >2BWG-A nrPDB Length = 367 Score = 31.6 bits (70), Expect = 1.5, Method: Composition-based stats. Identities = 20/120 (16%), Positives = 37/120 (30%), Gaps = 6/120 (5%) Query: 700 PAVLSVFGDIASNIGADFIPYLNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYV 759 P V + D+A+ F+ ++ + A T E ++ I ++ V Sbjct: 143 PQVKFICLDVANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGV 202 Query: 760 --GIVAGLHDKPEALFPYVGTIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGS 817 G V K +P + + + D GD+A F G+ Sbjct: 203 GPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCP----GDVAKAFGAGA 258 >4LAC-A nrPDB Length = 258 Score = 31.6 bits (70), Expect = 1.6, Method: Composition-based stats. Identities = 27/142 (19%), Positives = 59/142 (41%), Gaps = 14/142 (9%) Query: 386 REAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAES 445 REAA ++ +K + + +P +L + D + + TT +CI +++ + Sbjct: 128 REAATSNLKKLV---EKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQD 184 Query: 446 IDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEATPSPIYNFYPALVDGLIG 505 I + LP V++ + P N + N+ + L + P + + V ++ Sbjct: 185 ITTKHMLPTVLR-----MAGDP--VANVRF---NVAKSLQKIGPILDNSTLQSEVKPILE 234 Query: 506 AANRIDNEFNARASAFSALTTM 527 + D + + + A ALT + Sbjct: 235 KLTQ-DQDVDVKYFAQEALTVL 255 >1XYZ-A nrPDB Length = 347 Score = 31.2 bits (69), Expect = 1.9, Method: Composition-based stats. Identities = 11/65 (16%), Positives = 23/65 (35%), Gaps = 4/65 (6%) Query: 83 RWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIADIELPHGAWPELMKIMVDN 142 ++ + K + + + I+ RI + A ++ + ELMKI + N Sbjct: 241 EYLASIDQNIKRYAEIGVIVSFTEIDIRIPQSENPATA----FQVQANNYKELMKICLAN 296 Query: 143 TGAEQ 147 Sbjct: 297 PNCNT 301 >2X19-B nrPDB Length = 963 Score = 29.3 bits (64), Expect = 7.6, Method: Composition-based stats. Identities = 35/203 (17%), Positives = 82/203 (40%), Gaps = 15/203 (7%) Query: 267 LYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSPLQSYNFALSSIKDVV 326 ++ I N+ +S+T+ FW T+ ++ + A+ Q Y + DV+ Sbjct: 341 MFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFE---AEKQAVYQQVYRPVYFQLVDVL 397 Query: 327 PNLLNLLTRQN----EDPEDDDWNVSMS-AGACLQLFAQNCGNHILEPVLEFVEQNITAD 381 + + + E + + + L + G +L + + + + +T+ Sbjct: 398 LHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSS 457 Query: 382 N----WRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGR 437 W++ EA + F SI + D V L ++ ++ ++Q+ +T + IG Sbjct: 458 EEPYSWQHTEALLYGFQSIAETIDVNYSD--VVPGLIGLIPRISISNVQLADTVMFTIGA 515 Query: 438 IADSVAE-SIDPQQHLPGVVQAC 459 +++ +A+ + LP V+ A Sbjct: 516 LSEWLADHPVMINSVLPLVLHAL 538 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.128 0.330 Lambda K H 0.267 0.0395 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 26,840,972 Number of Sequences: 36641 Number of extensions: 954637 Number of successful extensions: 3073 Number of sequences better than 10.0: 35 Number of HSP's better than 10.0 without gapping: 23 Number of HSP's successfully gapped in prelim test: 43 Number of HSP's that attempted gapping in prelim test: 2861 Number of HSP's gapped (non-prelim): 126 length of query: 861 length of database: 10,336,785 effective HSP length: 106 effective length of query: 755 effective length of database: 6,452,839 effective search space: 4871893445 effective search space used: 4871893445 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 63 (28.9 bits)