BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q05823 (741 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4OAU-C nrPDB 1441 0.0 4O1O-A nrPDB 1023 0.0 5JHQ-A nrPDB 97 2e-20 5HKP-A nrPDB 88 1e-17 5MIO-C nrPDB 87 3e-17 5ET1-A nrPDB 83 5e-16 4PL5-B nrPDB 82 9e-16 5AQB-A nrPDB 82 9e-16 6HV0-A nrPDB 81 1e-15 5AQ9-A nrPDB 78 1e-14 5AQ7-A nrPDB 78 1e-14 5AQA-A nrPDB 78 1e-14 6FES-A nrPDB 77 2e-14 6MWQ-A nrPDB 77 3e-14 2RIO-A nrPDB 74 3e-13 5H76-A nrPDB 74 3e-13 4Z68-A nrPDB 72 8e-13 3EU9-A nrPDB 70 4e-12 3B7B-A nrPDB 67 3e-11 5CBO-A nrPDB 67 4e-11 4NIK-A nrPDB 67 4e-11 6BY9-A nrPDB 65 1e-10 2DWZ-A nrPDB 63 4e-10 4OT9-A nrPDB 63 5e-10 2KXP-C nrPDB 59 5e-09 3ZKJ-A nrPDB 58 1e-08 6AUN-A nrPDB 57 3e-08 5GP7-A nrPDB 57 4e-08 3VN9-A nrPDB 54 2e-07 3FME-A nrPDB 53 4e-07 1WG0-A nrPDB 50 2e-06 3COM-A nrPDB 49 8e-06 5D68-A nrPDB 48 2e-05 4CQG-A nrPDB 47 2e-05 3DB8-A nrPDB 46 7e-05 3M42-A nrPDB 45 8e-05 4D2V-A nrPDB 45 9e-05 6GU6-A nrPDB 45 2e-04 1BD8-A nrPDB 44 2e-04 3ALO-A nrPDB 44 3e-04 6AO5-A nrPDB 44 3e-04 4D28-A nrPDB 44 3e-04 1ZXE-A nrPDB 44 3e-04 2VD5-A nrPDB 43 4e-04 3T9K-A nrPDB 43 4e-04 6E2G-A nrPDB 43 4e-04 4LG4-A nrPDB 43 5e-04 4EQM-A nrPDB 43 5e-04 2VN9-A nrPDB 43 6e-04 4CZT-A nrPDB 42 8e-04 2Y7J-A nrPDB 42 9e-04 5UIL-A nrPDB 42 9e-04 6EMK-G nrPDB 42 0.001 5DND-A nrPDB 42 0.001 1BLX-B nrPDB 42 0.001 5Z33-A nrPDB 41 0.002 4JXF-A nrPDB 41 0.002 3EHQ-A nrPDB 41 0.002 1V0B-A nrPDB 40 0.003 6DMR-A nrPDB 40 0.003 3TKU-A nrPDB 40 0.003 4AU8-A nrPDB 40 0.004 1D9S-A nrPDB 40 0.004 5U6Y-A nrPDB 39 0.006 1G3N-A nrPDB 39 0.006 4AW2-A nrPDB 39 0.006 2RFA-A nrPDB 39 0.006 3UI2-A nrPDB 39 0.006 2VZ6-A nrPDB 39 0.007 4NIF-A nrPDB 39 0.008 3DEO-A nrPDB 39 0.009 3UIU-A nrPDB 39 0.010 6FDY-U nrPDB 39 0.012 2XNP-A nrPDB 39 0.012 3NIZ-A nrPDB 38 0.015 4JG6-A nrPDB 38 0.015 3BHH-A nrPDB 38 0.016 3MN3-A nrPDB 38 0.016 3SOA-A nrPDB 38 0.016 6CV9-A nrPDB 38 0.018 4NFN-A nrPDB 38 0.020 2OU7-A nrPDB 37 0.021 4J52-A nrPDB 37 0.024 6CUD-A nrPDB 37 0.027 4BTK-A nrPDB 37 0.028 5FG8-A nrPDB 37 0.029 3LJN-A nrPDB 37 0.032 5U0K-A nrPDB 37 0.035 1AD5-A nrPDB 37 0.037 2A1A-B nrPDB 37 0.041 4BSZ-B nrPDB 37 0.044 2F9G-A nrPDB 37 0.046 6E9W-A nrPDB 36 0.049 1NY3-A nrPDB 36 0.053 1FVR-A nrPDB 36 0.054 2OZA-A nrPDB 36 0.056 1G3N-B nrPDB 36 0.057 5IG1-A nrPDB 36 0.057 2W96-B nrPDB 36 0.057 4YNZ-A nrPDB 36 0.059 5CLR-A nrPDB 36 0.059 6BOA-A nrPDB 36 0.062 4C0T-A nrPDB 36 0.066 4RC3-A nrPDB 36 0.068 3BGP-A nrPDB 36 0.071 3KA0-A nrPDB 36 0.072 2YZA-A nrPDB 36 0.073 2PL0-A nrPDB 36 0.073 6BDL-A nrPDB 36 0.076 2BPM-A nrPDB 35 0.086 6CQF-A nrPDB 35 0.087 3PPZ-A nrPDB 35 0.088 5TUR-A nrPDB 35 0.094 6DVZ-A nrPDB 35 0.11 2BRG-A nrPDB 35 0.12 6G1K-A nrPDB 35 0.12 5LOH-A nrPDB 35 0.12 4QNY-A nrPDB 35 0.12 6CTH-A nrPDB 35 0.13 6BXI-A nrPDB 35 0.13 5EZV-A nrPDB 35 0.13 4CFF-A nrPDB 35 0.13 4AZW-A nrPDB 35 0.14 4AZV-A nrPDB 35 0.15 1S9I-A nrPDB 35 0.15 6DJS-A nrPDB 35 0.16 3QGY-A nrPDB 35 0.17 5WAX-A nrPDB 35 0.17 4N5Q-A nrPDB 34 0.18 3EB0-A nrPDB 34 0.19 1PHK-A nrPDB 34 0.19 5D9K-A nrPDB 34 0.19 4M7I-A nrPDB 34 0.20 3QD2-B nrPDB 34 0.29 4XD0-A nrPDB 34 0.29 5J5T-A nrPDB 33 0.30 5DBX-A nrPDB 33 0.32 5B2L-A nrPDB 33 0.32 3A8W-A nrPDB 33 0.33 1DCQ-A nrPDB 33 0.33 3OZ6-A nrPDB 33 0.35 3FXW-A nrPDB 33 0.36 3LZB-A nrPDB 33 0.37 2HK5-A nrPDB 33 0.37 3HKO-A nrPDB 33 0.39 5GNK-A nrPDB 33 0.40 3ZDU-A nrPDB 33 0.41 3DKO-A nrPDB 33 0.42 5FET-A nrPDB 33 0.46 4MVF-A nrPDB 33 0.47 5DYK-A nrPDB 33 0.47 3KUL-B nrPDB 33 0.49 1VZO-A nrPDB 33 0.51 5X1R-A nrPDB 33 0.55 4E7W-A nrPDB 33 0.56 2XIK-A nrPDB 33 0.56 4UZD-A nrPDB 33 0.58 2Z7Q-A nrPDB 33 0.58 4X7Q-B nrPDB 33 0.58 6ED6-A nrPDB 33 0.66 4AN9-A nrPDB 32 0.67 2V7O-A nrPDB 32 0.67 2R2P-A nrPDB 32 0.67 4QTB-A nrPDB 32 0.71 3EQC-A nrPDB 32 0.72 4P5Q-A nrPDB 32 0.73 3D2K-A nrPDB 32 0.74 4QHB-A nrPDB 32 0.74 4L11-A nrPDB 32 0.76 2PMN-X nrPDB 32 0.77 2BDW-A nrPDB 32 0.78 3KK8-A nrPDB 32 0.80 5KKR-C nrPDB 32 0.80 3BBT-B nrPDB 32 0.80 3H4J-B nrPDB 32 0.82 6CMJ-A nrPDB 32 0.84 3A4O-X nrPDB 32 0.85 5AIR-A nrPDB 32 0.86 4RED-A nrPDB 32 0.87 5YV8-A nrPDB 32 0.89 4CFH-A nrPDB 32 0.95 3ATG-A nrPDB 32 0.95 4PDS-A nrPDB 32 0.96 5XZW-A nrPDB 32 0.97 4REW-A nrPDB 32 1.0 2NYJ-A nrPDB 32 1.1 4LQP-A nrPDB 32 1.2 4IAN-A nrPDB 32 1.2 3HDN-A nrPDB 32 1.3 4M66-A nrPDB 32 1.3 5AR8-A nrPDB 32 1.3 4AGU-A nrPDB 32 1.3 3NCG-A nrPDB 32 1.4 2H34-A nrPDB 31 1.5 6FD3-A nrPDB 31 1.5 2DQ7-X nrPDB 31 1.7 5AWM-A nrPDB 31 1.7 4BGQ-A nrPDB 31 1.8 5G6V-A nrPDB 31 2.1 2JD5-A nrPDB 31 2.1 5JZN-A nrPDB 31 2.3 4U41-A nrPDB 31 2.3 6MHW-A nrPDB 30 2.6 3FI2-A nrPDB 30 2.7 4WUA-A nrPDB 30 2.8 3ORZ-A nrPDB 30 2.9 2XS0-A nrPDB 30 3.1 2Y6O-A nrPDB 30 3.2 4KS7-A nrPDB 30 3.3 1JNK-A nrPDB 30 3.3 2X7G-A nrPDB 30 3.5 6HXF-B nrPDB 30 3.6 5D7A-A nrPDB 30 3.6 4FR4-A nrPDB 30 3.8 3DFA-A nrPDB 30 3.9 3Q5I-A nrPDB 30 3.9 3UTO-A nrPDB 30 4.0 1KOA-A nrPDB 30 4.0 2QNJ-A nrPDB 30 4.1 6IRA-D nrPDB 30 4.2 3GC9-A nrPDB 30 4.4 5X8I-B nrPDB 30 4.5 3E7O-A nrPDB 30 4.6 4WJ3-A nrPDB 30 4.9 2HW6-A nrPDB 30 4.9 6CCF-A nrPDB 30 5.3 5IRX-A nrPDB 30 5.4 4WNO-A nrPDB 30 5.5 4PDO-A nrPDB 29 5.7 5XVU-A nrPDB 29 5.8 6O6Q-A nrPDB 29 5.8 5L6P-A nrPDB 29 5.8 2A5E-A nrPDB 29 5.9 4LFI-A nrPDB 29 6.5 5KZ7-A nrPDB 29 6.6 5E8V-A nrPDB 29 6.8 3DAK-A nrPDB 29 7.2 4CSV-A nrPDB 29 7.6 6C9D-A nrPDB 29 7.6 3SXS-A nrPDB 29 7.7 1KOB-A nrPDB 29 7.9 4FG9-A nrPDB 29 8.0 2YCR-A nrPDB 29 8.2 5VD3-A nrPDB 29 8.4 3I6U-A nrPDB 29 8.4 4XEY-B nrPDB 28 9.9 >4OAU-C nrPDB Length = 699 Score = 1441 bits (3729), Expect = 0.0, Method: Compositional matrix adjust. Identities = 698/699 (99%), Positives = 699/699 (100%) Query: 21 AAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLR 80 AAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLR Sbjct: 1 AAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLR 60 Query: 81 HGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKA 140 HGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKA Sbjct: 61 HGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKA 120 Query: 141 LKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDN 200 LKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDN Sbjct: 121 LKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDN 180 Query: 201 MGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLE 260 MGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLE Sbjct: 181 MGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLE 240 Query: 261 QEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVL 320 QEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVL Sbjct: 241 QEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVL 300 Query: 321 LSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIY 380 LSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIY Sbjct: 301 LSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIY 360 Query: 381 LGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQT 440 LGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQT Sbjct: 361 LGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQT 420 Query: 441 LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAH 500 LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAH Sbjct: 421 LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAH 480 Query: 501 LADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETK 560 LADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETK Sbjct: 481 LADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETK 540 Query: 561 DLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQP 620 DLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQP Sbjct: 541 DLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQP 600 Query: 621 GPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHIDEEKHKK 680 GPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGE+IDEEKHKK Sbjct: 601 GPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGENIDEEKHKK 660 Query: 681 MKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQT 719 MKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQT Sbjct: 661 MKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQT 699 >4O1O-A nrPDB Length = 717 Score = 1023 bits (2646), Expect = 0.0, Method: Compositional matrix adjust. Identities = 504/708 (71%), Positives = 582/708 (82%), Gaps = 12/708 (1%) Query: 28 LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVL 87 +L +AVQ D++ V+QLLE GA+ NFQEEE GW+PLH+AVQM ED+V LLL+HGADP L Sbjct: 11 MLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCL 70 Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147 RK+NGATPFI+A I G+V+LL+L L DVNECD GFTAFMEAAVYG+V+AL+FLY+ Sbjct: 71 RKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYEN 130 Query: 148 GANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALI 207 GA+VN+ RKTK+DQER+RKGGATALMDAAEKGHV V+ ILL M A+V+A DNMGRNAL+ Sbjct: 131 GADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALV 190 Query: 208 HALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEIN 267 +ALL+ DD +AIT LLLDHGADVNVRGE KTPLILAVE+K+L LVQ LLEQE IE+N Sbjct: 191 YALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVN 250 Query: 268 DTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKE 327 DTD +GKTALLLAVEL+L++IA+LLC RGAST+CGDLV ARRNYD LVK L H A E Sbjct: 251 DTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHKAGE 310 Query: 328 DFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQ 387 DF PPAE+WKPQSS WG ALK LHRI+RPMIGKLK FIDE+YKIADT+EGGIYLG YE Q Sbjct: 311 DFRPPAENWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYEDQ 370 Query: 388 EVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDV 447 EVAVK F EGS R Q+EVSCLQSSR N ++VTFYGSES L VC+ LCE TL+ L Sbjct: 371 EVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLAN 430 Query: 448 HRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 HRG+ V NEEDE ARN+LSS+FKA+ ELH S GY+HQDLQPQNILIDSK LADFDKS Sbjct: 431 HRGDAVPNEEDESARNILSSLFKAIGELHRS-GYSHQDLQPQNILIDSKNGTFLADFDKS 489 Query: 508 IKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLF 567 IKWA DPQ++KRDLE LG LVLYVVKKG ISFE LK QS EEV+Q SPDEET+DLIH LF Sbjct: 490 IKWAEDPQKIKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLF 549 Query: 568 HPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSK 627 HPG++V D LS LL HPFFW+WESRYRTLR+VGNESDIKTR S IL+LLQPG SE S Sbjct: 550 HPGDNVEDRLSSLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPGTSELST 609 Query: 628 SFDKWTTKINECVMKKMNKFYE-----------KRGNFYQNTVGDLLKFIRNLGEHIDEE 676 SF +WTTKI+ VM++MN +Y+ GN YQ+T+GDLLKFIRNLGEHI+E+ Sbjct: 610 SFAQWTTKIDSFVMEEMNAYYKKISKKKKAKHTNEGNLYQDTLGDLLKFIRNLGEHINEQ 669 Query: 677 KHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQTHSPNK 724 K+KKMK IG+PS YFQ+ FPDLV+YVYTKLQNTEY KHFP+TH+PNK Sbjct: 670 KNKKMKSIIGEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKTHNPNK 717 >5JHQ-A nrPDB Length = 482 Score = 97.4 bits (241), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 81/245 (33%), Positives = 124/245 (50%), Gaps = 18/245 (7%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEG-GWTPLHNAVQMSREDIVELLLRHGADPVL 87 L++A +N DV V++L++ ANVN ++ G +PLH A R+D+VE LL+ GA+ Sbjct: 19 LLEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 77 Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147 R G P A G +++ L L +GAD N D + +T EAA+ GK+ L + Sbjct: 78 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 137 Query: 148 GANVNLRRKTKEDQERLRKGGATA----------LMDAAEKGHVEVLKILLDEMGADVNA 197 GA+ N+R + L A A L++AA G+ E L LL + + +A Sbjct: 138 GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA 197 Query: 198 CDNMGRNAL-IHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQ 256 D GR + +H L++ + V I LLL HGADV+ + + G PL A H + + Sbjct: 198 SD--GRKSTPLH--LAAGYNRVR-IVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTE 252 Query: 257 RLLEQ 261 LL+ Sbjct: 253 LLLKH 257 Score = 88.6 bits (218), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 81/241 (33%), Positives = 114/241 (47%), Gaps = 17/241 (7%) Query: 50 NVNFQEEEG-GWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLL 108 NVN +G TPLH A +R IV+LLL+HGAD + K G P A G ++ Sbjct: 192 NVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVT 251 Query: 109 KLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGAN---VNLRRK-------TK 158 +L L GA VN D + FT EAA +V+ L GA+ VN K T Sbjct: 252 ELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTP 311 Query: 159 EDQERLRK--GGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDS 216 E +ERL G + L A E +V K L E+ +N +H ++S Sbjct: 312 ELRERLTYEFKGHSLLQAAREADLAKVKKTLALEI---INFKQPQSHETALHCAVASLHP 368 Query: 217 DVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTA 276 + +T LLL GA+VN + + TPL +A E+ H V +L + ++N D+ G+TA Sbjct: 369 KRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAH-NDVMEVLHKHGAKMNALDTLGQTA 427 Query: 277 L 277 L Sbjct: 428 L 428 Score = 55.5 bits (132), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 34/102 (33%), Positives = 55/102 (53%), Gaps = 1/102 (0%) Query: 27 HLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPV 86 H + ++ + + + LL GANVN ++ + TPLH A + + D++E+L +HGA Sbjct: 360 HCAVASLHPKRKQVTELLLRKGANVN-EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN 418 Query: 87 LRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTA 128 G T AA+AG ++ +L LS G+D + GFTA Sbjct: 419 ALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTA 460 Score = 53.1 bits (126), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 38/130 (29%), Positives = 67/130 (51%), Gaps = 4/130 (3%) Query: 27 HLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAV---QMSREDIVELLLRHGA 83 H L++A + D+ V++ L +NF++ + T LH AV R+ + ELLLR GA Sbjct: 324 HSLLQAAREADLAKVKKTL-ALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGA 382 Query: 84 DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKF 143 + + K+ TP +AA ++++ GA +N D G TA AA+ G ++ + Sbjct: 383 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRL 442 Query: 144 LYKRGANVNL 153 L G++ ++ Sbjct: 443 LLSYGSDPSI 452 >5HKP-A nrPDB Length = 351 Score = 87.8 bits (216), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 81/241 (33%), Positives = 113/241 (46%), Gaps = 17/241 (7%) Query: 50 NVNFQEEEG-GWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLL 108 NVN +G TPLH A +R IV+LLL+HGAD + K G P A G ++ Sbjct: 48 NVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVT 107 Query: 109 KLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGAN---VNLRRK-------TK 158 +L L GA VN D + FT EAA +V+ L GA+ VN K T Sbjct: 108 ELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTP 167 Query: 159 EDQERLRK--GGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDS 216 E +ERL G + L A E +V K L E+ +N +H ++S Sbjct: 168 ELRERLTYEFKGHSLLQAAREADLAKVKKTLALEI---INFKQPQSHETALHCAVASLHP 224 Query: 217 DVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTA 276 + + LLL GA+VN + + TPL +A E+ H V +L + ++N DS G+TA Sbjct: 225 KRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAH-NDVMEVLHKHGAKMNALDSLGQTA 283 Query: 277 L 277 L Sbjct: 284 L 284 Score = 55.8 bits (133), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 34/102 (33%), Positives = 55/102 (53%), Gaps = 1/102 (0%) Query: 27 HLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPV 86 H + ++ + + + LL GANVN ++ + TPLH A + + D++E+L +HGA Sbjct: 216 HCAVASLHPKRKQVAELLLRKGANVN-EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN 274 Query: 87 LRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTA 128 G T AA+AG ++ +L LS G+D + GFTA Sbjct: 275 ALDSLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTA 316 Score = 53.5 bits (127), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 42/146 (28%), Positives = 71/146 (48%), Gaps = 5/146 (3%) Query: 12 GPTSSSGRRAAVE-DNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAV--- 67 PT R E H L++A + D+ V++ L +NF++ + T LH AV Sbjct: 164 APTPELRERLTYEFKGHSLLQAAREADLAKVKKTL-ALEIINFKQPQSHETALHCAVASL 222 Query: 68 QMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFT 127 R+ + ELLLR GA+ + K+ TP +AA ++++ GA +N D G T Sbjct: 223 HPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDSLGQT 282 Query: 128 AFMEAAVYGKVKALKFLYKRGANVNL 153 A AA+ G ++ + L G++ ++ Sbjct: 283 ALHRAALAGHLQTCRLLLSYGSDPSI 308 Score = 32.0 bits (71), Expect = 1.1, Method: Compositional matrix adjust. Identities = 44/160 (27%), Positives = 64/160 (40%), Gaps = 45/160 (28%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNAL-IHALLSSDDSDVEAITHLLLDHGA 230 L++AA G+ E L LL + + +A D GR + +H L++ + V I LLL HGA Sbjct: 28 LLEAARSGNEEKLMALLTPLNVNCHASD--GRKSTPLH--LAAGYNRVR-IVQLLLQHGA 82 Query: 231 DVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAE 290 DV+ + + G PL A H ++ E Sbjct: 83 DVHAKDKGGLVPLHNACSYGHY----------------------------------EVTE 108 Query: 291 LLCKRGASTDCGDL-----VMTARRNYDHSLVKVLLSHGA 325 LL K GA + DL + A + +LLSHGA Sbjct: 109 LLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGA 148 >5MIO-C nrPDB Length = 573 Score = 87.0 bits (214), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 52/128 (40%), Positives = 76/128 (59%), Gaps = 1/128 (0%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 L++A + D V+ L+ GA+VN + G TPLH A +IVE+LL+HGAD Sbjct: 414 LLEAARAGQDDEVRVLMANGADVN-ATDASGLTPLHLAATYGHLEIVEVLLKHGADVSAS 472 Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG 148 G+TP LAA+ G ++++++ L GADVN D +G T AAV G +K ++ L K G Sbjct: 473 DLMGSTPLHLAALIGHLEIVEVLLKHGADVNAVDTWGDTPLRLAAVMGHLKIVEALLKHG 532 Query: 149 ANVNLRRK 156 A+VN + K Sbjct: 533 ADVNAQDK 540 Score = 72.8 bits (177), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 50/143 (34%), Positives = 77/143 (53%), Gaps = 11/143 (7%) Query: 63 LHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECD 122 L A + ++D V +L+ +GAD +G TP LAA G ++++++ L GADV+ D Sbjct: 414 LLEAARAGQDDEVRVLMANGADVNATDASGLTPLHLAATYGHLEIVEVLLKHGADVSASD 473 Query: 123 FYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVE 182 G T AA+ G ++ ++ L K GA+VN + G T L AA GH++ Sbjct: 474 LMGSTPLHLAALIGHLEIVEVLLKHGADVN----------AVDTWGDTPLRLAAVMGHLK 523 Query: 183 VLKILLDEMGADVNACDNMGRNA 205 +++ LL GADVNA D G+ A Sbjct: 524 IVEALLKH-GADVNAQDKFGKTA 545 Score = 71.2 bits (173), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 60/167 (35%), Positives = 87/167 (52%), Gaps = 18/167 (10%) Query: 129 FMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188 +EAA G+ ++ L GA+VN + G T L AA GH+E++++LL Sbjct: 414 LLEAARAGQDDEVRVLMANGADVNATDAS----------GLTPLHLAATYGHLEIVEVLL 463 Query: 189 DEMGADVNACDNMGRNAL-IHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAV 247 GADV+A D MG L + AL+ + I +LL HGADVN G TPL LA Sbjct: 464 KH-GADVSASDLMGSTPLHLAALIGHLE-----IVEVLLKHGADVNAVDTWGDTPLRLAA 517 Query: 248 EKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCK 294 HL +V+ LL+ ++N D GKTA +++ + +AE+L K Sbjct: 518 VMGHLKIVEALLKH-GADVNAQDKFGKTAYDTSIDNGSEDLAEILQK 563 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 39/92 (42%), Positives = 58/92 (63%), Gaps = 1/92 (1%) Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 97 +++V+ LL+ GA+V+ + G TPLH A + +IVE+LL+HGAD G TP Sbjct: 456 LEIVEVLLKHGADVSASDLMGS-TPLHLAALIGHLEIVEVLLKHGADVNAVDTWGDTPLR 514 Query: 98 LAAIAGSVKLLKLFLSKGADVNECDFYGFTAF 129 LAA+ G +K+++ L GADVN D +G TA+ Sbjct: 515 LAAVMGHLKIVEALLKHGADVNAQDKFGKTAY 546 Score = 62.0 bits (149), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/145 (37%), Positives = 76/145 (52%), Gaps = 8/145 (5%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 L++AA G + +++L+ GADVNA D G L H L++ +E I +LL HGAD Sbjct: 414 LLEAARAGQDDEVRVLMAN-GADVNATDASGLTPL-H--LAATYGHLE-IVEVLLKHGAD 468 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAEL 291 V+ G TPL LA HL +V+ LL+ ++N D+ G T L LA + KI E Sbjct: 469 VSASDLMGSTPLHLAALIGHLEIVEVLLKH-GADVNAVDTWGDTPLRLAAVMGHLKIVEA 527 Query: 292 LCKRGASTDCGDLVMTARRNYDHSL 316 L K GA + D + YD S+ Sbjct: 528 LLKHGADVNAQDKF--GKTAYDTSI 550 Score = 48.1 bits (113), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 43/131 (32%), Positives = 63/131 (48%), Gaps = 11/131 (8%) Query: 200 NMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLL 259 ++G+ L A DD +L+ +GADVN G TPL LA HL +V+ LL Sbjct: 409 DLGKKLLEAARAGQDDE-----VRVLMANGADVNATDASGLTPLHLAATYGHLEIVEVLL 463 Query: 260 EQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC----GDLVMTARRNYDH- 314 + +++ +D G T L LA + +I E+L K GA + GD + H Sbjct: 464 KH-GADVSASDLMGSTPLHLAALIGHLEIVEVLLKHGADVNAVDTWGDTPLRLAAVMGHL 522 Query: 315 SLVKVLLSHGA 325 +V+ LL HGA Sbjct: 523 KIVEALLKHGA 533 >5ET1-A nrPDB Length = 353 Score = 82.8 bits (203), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 77/271 (28%), Positives = 123/271 (45%), Gaps = 16/271 (5%) Query: 30 IKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADP-VLR 88 ++A + D+D+++ L G + P+H+A + + + L+ A P V R Sbjct: 8 LQAARRGDLDVLRSLHAAGLLGPSLRDSLDALPVHHAARSGKLHCLRYLVEEVALPAVSR 67 Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGA-DVNECDFYGFTAFMEAAVYGKVKALKFL-YK 146 +NGATP AA G + L+ L++G V E D G T AA +G +K+L Y+ Sbjct: 68 ARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVKWLLYQ 127 Query: 147 RGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNAL 206 GAN + T GA + AA KG + LK+L+ VNA N G L Sbjct: 128 GGANSAITTDT----------GALPIHYAAAKGDLPSLKLLVGHYPEGVNAQTNNGATPL 177 Query: 207 IHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEI 266 L+ + +E +L+ + AD ++R + G TPL A + H ++ L+ + Sbjct: 178 Y---LACQEGHLEVTKYLVQECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFADVSF 234 Query: 267 NDTDSDGKTALLLAVELKLKKIAELLCKRGA 297 ++ D DG TA+ A K+ L GA Sbjct: 235 SEQDHDGATAMHFAASRGHTKVLSWLLLHGA 265 Score = 37.0 bits (84), Expect = 0.030, Method: Compositional matrix adjust. Identities = 28/97 (28%), Positives = 47/97 (48%), Gaps = 2/97 (2%) Query: 49 ANVNFQEEE-GGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKL 107 A+V+F E++ G T +H A ++ LL HGA+ + + G TP AA G ++ Sbjct: 230 ADVSFSEQDHDGATAMHFAASRGHTKVLSWLLLHGAE-ISQDLWGGTPLHDAAENGELEC 288 Query: 108 LKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFL 144 ++ GA ++ D G+TA A G ++L Sbjct: 289 CQILAVNGAGLDVRDHDGYTAADLAEFNGHTHCSRYL 325 >4PL5-B nrPDB Length = 435 Score = 82.0 bits (201), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 105/434 (24%), Positives = 177/434 (40%), Gaps = 93/434 (21%) Query: 357 MIGKLKFFIDEKYKIADTSEGGI-YLGFYEKQEVAVK-TFCEGSPRAQREVSCLQSSREN 414 ++GK+ F K + +EG I Y G ++ ++VAVK E A REV L+ S E+ Sbjct: 23 IVGKISFC--PKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEH 80 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFAR------NVLSSI 468 +++ ++ +E R ++ + LC TL+ + E+ +FA +L Sbjct: 81 PNVIRYFCTEKDRQFQYIAIELCAATLQEYV----------EQKDFAHLGLEPITLLHQT 130 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDSKKA-----AHLADFDKSIKWAGD---------- 513 + LH S H+DL+P NIL+ A A ++DF K A Sbjct: 131 TSGLAHLH-SLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGV 189 Query: 514 --------PQEVKRDLED----------LGRLVLYVVKKGSISF-EDLKAQSN------- 547 P+ + D +D G + YV+ +G F + L+ Q+N Sbjct: 190 PGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILLGACN 249 Query: 548 ---------EEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRN 598 E+V+ ++LI ++ R +L HPFFW+ E + + ++ Sbjct: 250 LDCFHSDKHEDVI-------ARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQD 302 Query: 599 VGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNT 658 V + I+ + I+R L+ G K W I + + KF +G + Sbjct: 303 VSDR--IEKEALDGPIVRQLERGGRAVVKM--DWRENITVPLQTDLRKFRTYKG----GS 354 Query: 659 VGDLLKFIRNLGEHIDE---EKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKH 715 V DLL+ +RN H E E + + D YF FP L+ + Y ++ + + Sbjct: 355 VRDLLRAMRNKKHHYRELPVEVQETLGSIPDDFVRYFTSRFPHLLSHTYQAMELCRHERL 414 Query: 716 FPQT---HSPNKPQ 726 F QT H P +PQ Sbjct: 415 F-QTYYWHEPTEPQ 427 >5AQB-A nrPDB Length = 428 Score = 82.0 bits (201), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 52/128 (40%), Positives = 77/128 (60%), Gaps = 2/128 (1%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 L++A + D + L+ GA+VN +E G WTPLH A E IVE LL++GAD Sbjct: 18 LLEAARAGQDDECRILMANGADVNALDEVG-WTPLHLAAWGHLE-IVECLLKNGADVNAA 75 Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG 148 +G TP LAA +G ++++++ L GADVN D GFT AA++G ++ ++ L K G Sbjct: 76 DIDGYTPLHLAAFSGHLEIVEVLLKYGADVNADDQAGFTPLHLAAIFGHLEIVEVLLKNG 135 Query: 149 ANVNLRRK 156 A+VN + K Sbjct: 136 ADVNAQDK 143 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 73/206 (35%), Positives = 99/206 (48%), Gaps = 22/206 (10%) Query: 129 FMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188 +EAA G+ + L GA+VN L + G T L AA GH+E+++ LL Sbjct: 18 LLEAARAGQDDECRILMANGADVN----------ALDEVGWTPLHLAA-WGHLEIVECLL 66 Query: 189 DEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVE 248 GADVNA D G L A S VE +LL +GADVN + G TPL LA Sbjct: 67 KN-GADVNAADIDGYTPLHLAAFSGHLEIVE----VLLKYGADVNADDQAGFTPLHLAAI 121 Query: 249 KKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLV--M 306 HL +V+ LL + ++N D GKT LA++ + IAE+L K D + Sbjct: 122 FGHLEIVEVLL-KNGADVNAQDKFGKTPRDLAIDNGNEDIAEVLGKAATLVKVKDAADQL 180 Query: 307 TARRNY---DHSLVKVLLSHGAKEDF 329 AR Y D + K+L S ++E F Sbjct: 181 GARVGYIELDLNSGKILESFRSEERF 206 >6HV0-A nrPDB Length = 416 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 99/414 (23%), Positives = 167/414 (40%), Gaps = 75/414 (18%) Query: 357 MIGKLKFFIDEKYKIADTSEGGI-YLGFYEKQEVAVKTFC-EGSPRAQREVSCLQSSREN 414 ++GK+ F K + +EG I Y G ++ ++VAVK E A REV L+ S E+ Sbjct: 4 IVGKISFC--PKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEH 61 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFAR------NVLSSI 468 +++ ++ +E R ++ + LC TL+ + E+ +FA +L Sbjct: 62 PNVIRYFCTEKDRQFQYIAIELCAATLQEYV----------EQKDFAHLGLEPITLLQQT 111 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDSKKA-----AHLADFDKSIKWAGDPQEVKR---- 519 + LH S H+DL+P NILI A A ++DF K A R Sbjct: 112 TSGLAHLH-SLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGV 170 Query: 520 ------------------------DLEDLGRLVLYVVKKGSISF-EDLKAQSNEEVVQLS 554 D+ G + YV+ +GS F + L+ Q+N + S Sbjct: 171 PGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACS 230 Query: 555 ---------PDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDI 605 D ++LI ++ R +L HPFFW+ E + + ++V + I Sbjct: 231 LDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDR--I 288 Query: 606 KTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKF 665 + + I++ L+ G K W I + + KF +G +V DLL+ Sbjct: 289 EKESLDGPIVKQLERGGRAVVKM--DWRENITVPLQTDLRKFRTYKG----GSVRDLLRA 342 Query: 666 IRNLGEHIDE---EKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHF 716 +RN H E E + + D YF FP L+ + Y ++ + + F Sbjct: 343 MRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLF 396 >5AQ9-A nrPDB Length = 422 Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 50/128 (39%), Positives = 73/128 (57%), Gaps = 1/128 (0%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 L++A + D V+ L+ GA+VN + G TPLH A +IVE+LL+HGAD Sbjct: 18 LLEAARAGQDDEVRILMANGADVNAADNTGT-TPLHLAAYSGHLEIVEVLLKHGADVDAS 76 Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG 148 G TP LAA G ++++++ L GADVN D G T AA +G ++ ++ L K G Sbjct: 77 DVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEIVEVLLKHG 136 Query: 149 ANVNLRRK 156 A+VN + K Sbjct: 137 ADVNAQDK 144 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 54/132 (40%), Positives = 71/132 (53%), Gaps = 6/132 (4%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 L++AA G + ++IL+ GADVNA DN G L A S VE +LL HGAD Sbjct: 18 LLEAARAGQDDEVRILMAN-GADVNAADNTGTTPLHLAAYSGHLEIVE----VLLKHGAD 72 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAEL 291 V+ G TPL LA HL +V+ LL + ++N DSDG T L LA + +I E+ Sbjct: 73 VDASDVFGYTPLHLAAYWGHLEIVEVLL-KNGADVNAMDSDGMTPLHLAAKWGYLEIVEV 131 Query: 292 LCKRGASTDCGD 303 L K GA + D Sbjct: 132 LLKHGADVNAQD 143 Score = 69.3 bits (168), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 57/148 (38%), Positives = 80/148 (54%), Gaps = 15/148 (10%) Query: 99 AAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTK 158 AA AG +++ ++ GADVN D G T AA G ++ ++ L K GA+V+ Sbjct: 21 AARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVF- 79 Query: 159 EDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDV 218 G T L AA GH+E++++LL GADVNA D+ G L H L++ + Sbjct: 80 ---------GYTPLHLAAYWGHLEIVEVLLKN-GADVNAMDSDGMTPL-H--LAAKWGYL 126 Query: 219 EAITHLLLDHGADVNVRGERGKTPLILA 246 E I +LL HGADVN + + GKTP LA Sbjct: 127 E-IVEVLLKHGADVNAQDKFGKTPFDLA 153 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 37/92 (40%), Positives = 58/92 (63%), Gaps = 1/92 (1%) Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 97 +++V+ LL+ GA+V+ + G+TPLH A +IVE+LL++GAD +G TP Sbjct: 60 LEIVEVLLKHGADVD-ASDVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLH 118 Query: 98 LAAIAGSVKLLKLFLSKGADVNECDFYGFTAF 129 LAA G ++++++ L GADVN D +G T F Sbjct: 119 LAAKWGYLEIVEVLLKHGADVNAQDKFGKTPF 150 Score = 52.4 bits (124), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 46/132 (34%), Positives = 65/132 (49%), Gaps = 13/132 (9%) Query: 200 NMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLL 259 ++GR L A DD +L+ +GADVN G TPL LA HL +V+ LL Sbjct: 13 DLGRKLLEAARAGQDDE-----VRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLL 67 Query: 260 EQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGD------LVMTARRNYD 313 + +++ +D G T L LA +I E+L K GA + D L + A+ Y Sbjct: 68 KH-GADVDASDVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGY- 125 Query: 314 HSLVKVLLSHGA 325 +V+VLL HGA Sbjct: 126 LEIVEVLLKHGA 137 Score = 52.0 bits (123), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 29/62 (46%), Positives = 42/62 (67%), Gaps = 1/62 (1%) Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 97 +++V+ LL+ GA+VN + +G TPLH A + +IVE+LL+HGAD + K G TPF Sbjct: 93 LEIVEVLLKNGADVNAMDSDG-MTPLHLAAKWGYLEIVEVLLKHGADVNAQDKFGKTPFD 151 Query: 98 LA 99 LA Sbjct: 152 LA 153 >5AQ7-A nrPDB Length = 418 Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 55/155 (35%), Positives = 83/155 (53%), Gaps = 11/155 (7%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 L++A + D V+ LL GA+VN +E G +TPLH A IVE+LL++GAD Sbjct: 18 LLEAARAGQDDEVRILLANGADVNTADETG-FTPLHLAAWEGHLGIVEVLLKNGADVNAN 76 Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG 148 + G TP LAA G ++++++ L GA VN D G AA++G + ++ L K G Sbjct: 77 DERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGYKEIVEVLLKAG 136 Query: 149 ANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEV 183 A+V+ + K G L AA++GH E+ Sbjct: 137 ADVDAQDKF----------GKRPLWLAADQGHAEI 161 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 59/161 (36%), Positives = 85/161 (52%), Gaps = 15/161 (9%) Query: 99 AAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTK 158 AA AG +++ L+ GADVN D GFT AA G + ++ L K GA+VN Sbjct: 21 AARAGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVN------ 74 Query: 159 EDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDV 218 + ER G T L AA GH+E++++LL GA VNA D +G L A + Sbjct: 75 ANDER----GHTPLHLAAYTGHLEIVEVLLKN-GAGVNATDVIGTAPLHLAAMWG----Y 125 Query: 219 EAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLL 259 + I +LL GADV+ + + GK PL LA ++ H + +L+ Sbjct: 126 KEIVEVLLKAGADVDAQDKFGKRPLWLAADQGHAEIAAKLV 166 Score = 67.8 bits (164), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 54/132 (40%), Positives = 67/132 (50%), Gaps = 6/132 (4%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 L++AA G + ++ILL GADVN D G L A VE +LL +GAD Sbjct: 18 LLEAARAGQDDEVRILLAN-GADVNTADETGFTPLHLAAWEGHLGIVE----VLLKNGAD 72 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAEL 291 VN ERG TPL LA HL +V+ LL + +N TD G L LA K+I E+ Sbjct: 73 VNANDERGHTPLHLAAYTGHLEIVEVLL-KNGAGVNATDVIGTAPLHLAAMWGYKEIVEV 131 Query: 292 LCKRGASTDCGD 303 L K GA D D Sbjct: 132 LLKAGADVDAQD 143 Score = 58.9 bits (141), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 47/128 (36%), Positives = 66/128 (51%), Gaps = 10/128 (7%) Query: 206 LIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIE 265 L+ A + D +V +LL +GADVN E G TPL LA + HLG+V+ LL + + Sbjct: 18 LLEAARAGQDDEV----RILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLL-KNGAD 72 Query: 266 INDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYD-----HSLVKVL 320 +N D G T L LA +I E+L K GA + D++ TA + +V+VL Sbjct: 73 VNANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGYKEIVEVL 132 Query: 321 LSHGAKED 328 L GA D Sbjct: 133 LKAGADVD 140 >5AQA-A nrPDB Length = 418 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 56/155 (36%), Positives = 82/155 (52%), Gaps = 11/155 (7%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 L++A + D V+ L+ GA+VN + G TPLH A +IVE+LL+HGAD Sbjct: 18 LLEAARAGQDDEVRILMANGADVNAADNTGT-TPLHLAAYSGHLEIVEVLLKHGADVDAS 76 Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG 148 G TP LAA G ++++++ L GADVN D G T AA +G + ++ L K G Sbjct: 77 DVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYKEIVEVLLKAG 136 Query: 149 ANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEV 183 A+V+ + K G L AA++GH E+ Sbjct: 137 ADVDAQDKF----------GKRPLWLAADQGHAEI 161 Score = 75.1 bits (183), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 56/132 (42%), Positives = 72/132 (54%), Gaps = 6/132 (4%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 L++AA G + ++IL+ GADVNA DN G L A S VE +LL HGAD Sbjct: 18 LLEAARAGQDDEVRILMAN-GADVNAADNTGTTPLHLAAYSGHLEIVE----VLLKHGAD 72 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAEL 291 V+ G TPL LA HL +V+ LL + ++N DSDG T L LA + K+I E+ Sbjct: 73 VDASDVFGYTPLHLAAYWGHLEIVEVLL-KNGADVNAMDSDGMTPLHLAAKWGYKEIVEV 131 Query: 292 LCKRGASTDCGD 303 L K GA D D Sbjct: 132 LLKAGADVDAQD 143 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 55/161 (34%), Positives = 82/161 (50%), Gaps = 15/161 (9%) Query: 99 AAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTK 158 AA AG +++ ++ GADVN D G T AA G ++ ++ L K GA+V+ Sbjct: 21 AARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVF- 79 Query: 159 EDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDV 218 G T L AA GH+E++++LL GADVNA D+ G L A Sbjct: 80 ---------GYTPLHLAAYWGHLEIVEVLLKN-GADVNAMDSDGMTPLHLAA----KWGY 125 Query: 219 EAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLL 259 + I +LL GADV+ + + GK PL LA ++ H + +L+ Sbjct: 126 KEIVEVLLKAGADVDAQDKFGKRPLWLAADQGHAEIAAKLV 166 Score = 30.8 bits (68), Expect = 2.0, Method: Compositional matrix adjust. Identities = 24/74 (32%), Positives = 36/74 (48%), Gaps = 5/74 (6%) Query: 257 RLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLV----MTARRNY 312 R+L ++N D+ G T L LA +I E+L K GA D D+ + + Sbjct: 31 RILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVFGYTPLHLAAYW 90 Query: 313 DH-SLVKVLLSHGA 325 H +V+VLL +GA Sbjct: 91 GHLEIVEVLLKNGA 104 >6FES-A nrPDB Length = 367 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 60/181 (33%), Positives = 95/181 (52%), Gaps = 13/181 (7%) Query: 12 GPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSR 71 GP S G++ L++A + D V+ LL GA+VN +E G+TPLH A Sbjct: 1 GPGSDLGKK--------LLEAARAGQDDEVRILLANGADVN-TADETGFTPLHLAAWEGH 51 Query: 72 EDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFME 131 IVE+LL++GAD + G TP LAA G ++++++ L GA VN D G Sbjct: 52 LGIVEVLLKNGADVNANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHL 111 Query: 132 AAVYGKVKALKFLYKRGANVNLRRKTKEDQERL-RKGGATALMDAAEKGHVEVLKILLDE 190 AA++G + ++ L K GA+ + K + E L R G ++ A K E+++ ++DE Sbjct: 112 AAMWGHEEIVEVLLKNGADARAQDKFGKTPEDLARDNGYESVARLARK---EIIRAVVDE 168 Query: 191 M 191 + Sbjct: 169 L 169 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 57/175 (32%), Positives = 85/175 (48%), Gaps = 15/175 (8%) Query: 200 NMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLL 259 ++G+ L A DD +LL +GADVN E G TPL LA + HLG+V+ LL Sbjct: 5 DLGKKLLEAARAGQDDE-----VRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLL 59 Query: 260 EQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRN----YDH- 314 + ++N D G T L LA +I E+L K GA + D++ TA + + H Sbjct: 60 -KNGADVNANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGHE 118 Query: 315 SLVKVLLSHG----AKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFI 365 +V+VLL +G A++ F ED + + A I R ++ +LK I Sbjct: 119 EIVEVLLKNGADARAQDKFGKTPEDLARDNGYESVARLARKEIIRAVVDELKELI 173 Score = 59.3 bits (142), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 52/132 (39%), Positives = 70/132 (53%), Gaps = 6/132 (4%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 L++AA G + ++ILL GADVN D G L H L++ + + I +LL +GAD Sbjct: 10 LLEAARAGQDDEVRILLAN-GADVNTADETGFTPL-H--LAAWEGHL-GIVEVLLKNGAD 64 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAEL 291 VN ERG TPL LA HL +V+ LL + +N TD G L LA ++I E+ Sbjct: 65 VNANDERGHTPLHLAAYTGHLEIVEVLL-KNGAGVNATDVIGTAPLHLAAMWGHEEIVEV 123 Query: 292 LCKRGASTDCGD 303 L K GA D Sbjct: 124 LLKNGADARAQD 135 >6MWQ-A nrPDB Length = 493 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 50/128 (39%), Positives = 73/128 (57%), Gaps = 1/128 (0%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 L++A + D V+ L+ GA+VN + G TPLH A Q +IVE+LL+ GAD Sbjct: 9 LLEAARAGQDDEVRILMANGADVNALDRFG-LTPLHLAAQRGHLEIVEVLLKCGADVNAA 67 Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG 148 G TP LAA AG ++++++ L GADVN D G T A+ G ++ ++ L K G Sbjct: 68 DLWGQTPLHLAATAGHLEIVEVLLKYGADVNALDLIGKTPLHLTAIDGHLEIVEVLLKHG 127 Query: 149 ANVNLRRK 156 A+VN + K Sbjct: 128 ADVNAQDK 135 Score = 75.9 bits (185), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 58/160 (36%), Positives = 89/160 (55%), Gaps = 15/160 (9%) Query: 99 AAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTK 158 AA AG +++ ++ GADVN D +G T AA G ++ ++ L K GA+VN Sbjct: 12 AARAGQDDEVRILMANGADVNALDRFGLTPLHLAAQRGHLEIVEVLLKCGADVNAADLW- 70 Query: 159 EDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDV 218 G T L AA GH+E++++LL + GADVNA D +G+ L H L++ D + Sbjct: 71 ---------GQTPLHLAATAGHLEIVEVLL-KYGADVNALDLIGKTPL-H--LTAIDGHL 117 Query: 219 EAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRL 258 E I +LL HGADVN + + GKT ++++ + L + L Sbjct: 118 E-IVEVLLKHGADVNAQDKFGKTAFDISIDNGNEDLAEIL 156 Score = 53.1 bits (126), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 46/132 (34%), Positives = 68/132 (51%), Gaps = 13/132 (9%) Query: 200 NMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLL 259 ++G+ L A DD +L+ +GADVN G TPL LA ++ HL +V+ LL Sbjct: 4 DLGKKLLEAARAGQDDE-----VRILMANGADVNALDRFGLTPLHLAAQRGHLEIVEVLL 58 Query: 260 EQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLV------MTARRNYD 313 + ++N D G+T L LA +I E+L K GA + DL+ +TA + Sbjct: 59 KC-GADVNAADLWGQTPLHLAATAGHLEIVEVLLKYGADVNALDLIGKTPLHLTAIDGH- 116 Query: 314 HSLVKVLLSHGA 325 +V+VLL HGA Sbjct: 117 LEIVEVLLKHGA 128 >2RIO-A nrPDB Length = 434 Score = 73.6 bits (179), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 98/411 (23%), Positives = 165/411 (40%), Gaps = 84/411 (20%) Query: 365 IDEKYKIADTSEGGIYLGFYEKQEVAVKT----FCEGSPRAQREVSCLQSSRENSHLVTF 420 + EK +S ++ G ++ + VAVK FC+ A E+ L S ++ +++ + Sbjct: 18 VSEKILGYGSSGTVVFQGSFQGRPVAVKRMLIDFCDI---ALMEIKLLTESDDHPNVIRY 74 Query: 421 YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFAR-----NVLSSIFKAVQEL 475 Y SE+ L++ + LC L+ D+ ++V +E + + ++L I V L Sbjct: 75 YCSETTDRFLYIALELCNLNLQ---DLVESKNVSDENLKLQKEYNPISLLRQIASGVAHL 131 Query: 476 HLSCGYTHQDLQPQNILI--------DSKKAAH-----LADFDKSIK------------- 509 H S H+DL+PQNIL+ D + A ++DF K Sbjct: 132 H-SLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLN 190 Query: 510 -------W--------AGDPQEVKR-----DLEDLGRLVLYVVKKGSISFEDLKAQSNEE 549 W + + Q +R D+ +G + Y++ KG F D K Sbjct: 191 NPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGD-KYSRESN 249 Query: 550 VVQ--LSPDE-----------ETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTL 596 +++ S DE E DLI ++ R +L HP FW + L Sbjct: 250 IIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFL 309 Query: 597 RNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQ 656 V + +I+ R S +L G S D WT K ++ M + E+ ++ Sbjct: 310 LKVSDRLEIENRDPPSALLMKFDAGSDFVIPSGD-WTVKFDKTFMDNL----ERYRKYHS 364 Query: 657 NTVGDLLKFIRNLGEHIDEEKHKKMKLKIGDPSL---YFQKTFPDLVIYVY 704 + + DLL+ +RN H + +L P YF K FP+L+I VY Sbjct: 365 SKLMDLLRALRNKYHHFMDLPEDIAELMGPVPDGFYDYFTKRFPNLLIGVY 415 >5H76-A nrPDB Length = 201 Score = 73.6 bits (179), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 50/128 (39%), Positives = 72/128 (56%), Gaps = 2/128 (1%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 L++A + D V+ L+ GA+VN + G TPLH A +IVE+LL+HGAD Sbjct: 10 LLEAARAGQDDEVRILMANGADVNAADNTGT-TPLHLAAYSGHLEIVEVLLKHGADVDAS 68 Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG 148 G TP LAA G ++++++ L GADVN D G T AA +G ++ ++ L K G Sbjct: 69 DVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEIVEVLLKHG 128 Query: 149 ANVNLRRK 156 A VN + K Sbjct: 129 A-VNAQDK 135 Score = 67.8 bits (164), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 53/126 (42%), Positives = 69/126 (54%), Gaps = 6/126 (4%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 L++AA G + ++IL+ GADVNA DN G L A S VE +LL HGAD Sbjct: 10 LLEAARAGQDDEVRILMAN-GADVNAADNTGTTPLHLAAYSGHLEIVE----VLLKHGAD 64 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAEL 291 V+ G TPL LA HL +V+ LL+ ++N DSDG T L LA + +I E+ Sbjct: 65 VDASDVFGYTPLHLAAYWGHLEIVEVLLKNG-ADVNAMDSDGMTPLHLAAKWGYLEIVEV 123 Query: 292 LCKRGA 297 L K GA Sbjct: 124 LLKHGA 129 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 58/165 (35%), Positives = 89/165 (53%), Gaps = 17/165 (10%) Query: 129 FMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188 +EAA G+ ++ L GA+VN T G T L AA GH+E++++LL Sbjct: 10 LLEAARAGQDDEVRILMANGADVNAADNT----------GTTPLHLAAYSGHLEIVEVLL 59 Query: 189 DEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVE 248 + GADV+A D G L H L++ +E I +LL +GADVN G TPL LA + Sbjct: 60 -KHGADVDASDVFGYTPL-H--LAAYWGHLE-IVEVLLKNGADVNAMDSDGMTPLHLAAK 114 Query: 249 KKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLC 293 +L +V+ LL +H +N D GKTA ++++ + +A++L Sbjct: 115 WGYLEIVEVLL--KHGAVNAQDKFGKTAFDISIDNGNEDLAQILA 157 Score = 31.2 bits (69), Expect = 1.5, Method: Compositional matrix adjust. Identities = 24/74 (32%), Positives = 36/74 (48%), Gaps = 5/74 (6%) Query: 257 RLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLV----MTARRNY 312 R+L ++N D+ G T L LA +I E+L K GA D D+ + + Sbjct: 23 RILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVFGYTPLHLAAYW 82 Query: 313 DH-SLVKVLLSHGA 325 H +V+VLL +GA Sbjct: 83 GHLEIVEVLLKNGA 96 >4Z68-A nrPDB Length = 155 Score = 72.4 bits (176), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 52/152 (34%), Positives = 77/152 (50%), Gaps = 2/152 (1%) Query: 24 EDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGW-TPLHNAVQMSREDIVELLLRHG 82 E + L++A + DV+ V++L +VN ++ EG TPLH A +R +VE LL+HG Sbjct: 2 EADRQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHG 60 Query: 83 ADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALK 142 AD + K G P A G ++ +L + GA VN D + FT EAA GK + K Sbjct: 61 ADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICK 120 Query: 143 FLYKRGANVNLRRKTKEDQERLRKGGATALMD 174 L + GA+ + + L K G T + D Sbjct: 121 LLLQHGADPTKKNRDGNTPLDLVKDGDTDIQD 152 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 48/149 (32%), Positives = 71/149 (47%), Gaps = 18/149 (12%) Query: 99 AAIAGSVKLLKLFLSKGADVNECDFYG--FTAFMEAAVYGKVKALKFLYKRGANVNLRRK 156 AA AG V+ +K + + VN D G T AA Y +V +++L + GA+V+ + K Sbjct: 10 AAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDK 68 Query: 157 TKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDS 216 GG L +A GH EV ++L+ + GA VN D + + +H + Sbjct: 69 ----------GGLVPLHNACSYGHYEVAELLV-KHGAVVNVAD-LWKFTPLHEAAAKGKY 116 Query: 217 DVEAITHLLLDHGADVNVRGERGKTPLIL 245 + I LLL HGAD + G TPL L Sbjct: 117 E---ICKLLLQHGADPTKKNRDGNTPLDL 142 Score = 35.0 bits (79), Expect = 0.11, Method: Compositional matrix adjust. Identities = 37/123 (30%), Positives = 54/123 (43%), Gaps = 10/123 (8%) Query: 210 LLSSDDSDVEAITHLLLDHGADVNVRGERGK--TPLILAVEKKHLGLVQRLLEQEHIEIN 267 L ++ DVE + L VN R G+ TPL A + +V+ LL Q +++ Sbjct: 8 LEAAKAGDVETVKKLCTVQS--VNCRDIEGRQSTPLHFAAGYNRVSVVEYLL-QHGADVH 64 Query: 268 DTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDL-----VMTARRNYDHSLVKVLLS 322 D G L A ++AELL K GA + DL + A + + K+LL Sbjct: 65 AKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQ 124 Query: 323 HGA 325 HGA Sbjct: 125 HGA 127 >3EU9-A nrPDB Length = 240 Score = 70.1 bits (170), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 66/207 (31%), Positives = 97/207 (46%), Gaps = 14/207 (6%) Query: 19 RRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELL 78 R+ E+ LL A N +DLV+ + GA V+ + TPLH A + +V L Sbjct: 36 RQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQL 95 Query: 79 LRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYG-K 137 +++GADP L G + LAA G ++ ++KG DV+ D G T M AA Sbjct: 96 MKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHS 155 Query: 138 VKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNA 197 V + L +VNL K ++ TAL A G+ V+ +LL E GA+V+A Sbjct: 156 VDPTRLLLTFNVSVNLGDKYHKN---------TALHWAVLAGNTTVISLLL-EAGANVDA 205 Query: 198 CDNMGRNALIHALLSSDDSDVEAITHL 224 + G +AL L+ +V I HL Sbjct: 206 QNIKGESALD---LAKQRKNVWMINHL 229 Score = 66.6 bits (161), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 63/237 (26%), Positives = 119/237 (50%), Gaps = 23/237 (9%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 ++KA Q + ++L+E G +V ++E T LH A +R D+V+ + GA ++ Sbjct: 13 IVKATQYGIYERCRELVEAGYDVRQPDKENV-TLLHWAAINNRIDLVKYYISKGA--IVD 69 Query: 89 KKNG---ATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLY 145 + G +TP A G + ++ + GAD + D G + AA +G + +L Sbjct: 70 QLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLI 129 Query: 146 KRGANVNLRRKTKEDQERLRKGGATALMDAAEKGH-VEVLKILLDEMGADVNACDNMGRN 204 +G +V++ + + G T LM AA + H V+ ++LL VN D +N Sbjct: 130 AKGQDVDM----------MDQNGMTPLMWAAYRTHSVDPTRLLL-TFNVSVNLGDKYHKN 178 Query: 205 ALIH-ALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLE 260 +H A+L+ + + + LLL+ GA+V+ + +G++ L LA ++K++ ++ L E Sbjct: 179 TALHWAVLAGNTT----VISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQE 231 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 53/198 (26%), Positives = 88/198 (44%), Gaps = 21/198 (10%) Query: 111 FLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGG-- 168 + G DV + D T AA+ ++ +K+ +GA V+ + GG Sbjct: 28 LVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVD------------QLGGDL 75 Query: 169 -ATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLD 227 +T L A +GH+ ++ + L + GAD + D G + IH + + A L+ Sbjct: 76 NSTPLHWATRQGHLSMV-VQLMKYGADPSLIDGEGCSC-IHLAAQFGHTSIVA---YLIA 130 Query: 228 HGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGK-TALLLAVELKLK 286 G DV++ + G TPL+ A + H RLL ++ +N D K TAL AV Sbjct: 131 KGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNT 190 Query: 287 KIAELLCKRGASTDCGDL 304 + LL + GA+ D ++ Sbjct: 191 TVISLLLEAGANVDAQNI 208 >3B7B-A nrPDB Length = 237 Score = 67.0 bits (162), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 62/212 (29%), Positives = 111/212 (52%), Gaps = 21/212 (9%) Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGA--DPVLRKKNGATP 95 VD+ L++ GAN++ E+ TPL A + + + V+ L++ GA DP + G+T Sbjct: 24 VDICHMLVQAGANIDTCSEDQR-TPLMEAAENNHLEAVKYLIKAGALVDP--KDAEGSTC 80 Query: 96 FILAAIAGSVKLLKLFLSKG-ADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLR 154 LAA G ++++ LS G DVN D G+T + A Y V +K L +G+++N+R Sbjct: 81 LHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIR 140 Query: 155 RKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSD 214 +++E + L AA G V++ +ILL D++A + G + L +++ Sbjct: 141 ----DNEENI------CLHWAAFSGCVDIAEILL-AAKCDLHAVNIHGDSPL---HIAAR 186 Query: 215 DSDVEAITHLLLDHGADVNVRGERGKTPLILA 246 ++ + + L L +DV ++ + G+TPL A Sbjct: 187 ENRYDCVV-LFLSRDSDVTLKNKEGETPLQCA 217 Score = 63.5 bits (153), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 62/232 (26%), Positives = 110/232 (47%), Gaps = 16/232 (6%) Query: 50 NVNFQ-EEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLL 108 ++NF+ E + +PLH A + DI +L++ GA+ ++ TP + AA ++ + Sbjct: 1 HMNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAV 60 Query: 109 KLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGG 168 K + GA V+ D G T AA G + +++L G + ++D GG Sbjct: 61 KYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNG---QMDVNCQDD------GG 111 Query: 169 ATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDH 228 T ++ A E HV+++K+LL + G+D+N DN N +H S D I +LL Sbjct: 112 WTPMIWATEYKHVDLVKLLLSK-GSDINIRDN-EENICLHWAAFSGCVD---IAEILLAA 166 Query: 229 GADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLA 280 D++ G +PL +A + V L ++ ++ + +G+T L A Sbjct: 167 KCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDS-DVTLKNKEGETPLQCA 217 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 42/134 (31%), Positives = 74/134 (55%), Gaps = 5/134 (3%) Query: 170 TALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHG 229 + L AAE GHV++ +L+ + GA+++ C R L+ A ++++ +EA+ +L+ G Sbjct: 13 SPLHAAAEAGHVDICHMLV-QAGANIDTCSEDQRTPLMEA---AENNHLEAVKYLI-KAG 67 Query: 230 ADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIA 289 A V+ + G T L LA +K H +VQ LL +++N D G T ++ A E K + Sbjct: 68 ALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLV 127 Query: 290 ELLCKRGASTDCGD 303 +LL +G+ + D Sbjct: 128 KLLLSKGSDINIRD 141 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 1/110 (0%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 +I A + + VDLV+ LL G+++N ++ E LH A DI E+LL D Sbjct: 115 MIWATEYKHVDLVKLLLSKGSDINIRDNEEN-ICLHWAAFSGCVDIAEILLAAKCDLHAV 173 Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKV 138 +G +P +AA + LFLS+ +DV + G T A++ +V Sbjct: 174 NIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQV 223 >5CBO-A nrPDB Length = 176 Score = 66.6 bits (161), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 49/126 (38%), Positives = 71/126 (56%), Gaps = 6/126 (4%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 L++AA G + ++IL+ GADVNA DN G L A VE +LL +GAD Sbjct: 7 LLEAAHAGQDDEVRILMAN-GADVNAMDNFGVTPLHLAAYWGHFEIVE----VLLKYGAD 61 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAEL 291 VN G TPL LA + +LG+V+ LL+ ++N D GKTA ++++ + +AE+ Sbjct: 62 VNASDATGDTPLHLAAKWGYLGIVEVLLKY-GADVNAQDKFGKTAFDISIDNGNEDLAEI 120 Query: 292 LCKRGA 297 LCK A Sbjct: 121 LCKNKA 126 Score = 63.2 bits (152), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 41/101 (40%), Positives = 57/101 (56%), Gaps = 1/101 (0%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 L++A D V+ L+ GA+VN + G TPLH A +IVE+LL++GAD Sbjct: 7 LLEAAHAGQDDEVRILMANGADVNAMDNFG-VTPLHLAAYWGHFEIVEVLLKYGADVNAS 65 Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAF 129 G TP LAA G + ++++ L GADVN D +G TAF Sbjct: 66 DATGDTPLHLAAKWGYLGIVEVLLKYGADVNAQDKFGKTAF 106 Score = 55.8 bits (133), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 44/149 (29%), Positives = 69/149 (46%), Gaps = 20/149 (13%) Query: 63 LHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECD 122 L A ++D V +L+ +GAD G TP LAA G +++++ L GADVN D Sbjct: 7 LLEAAHAGQDDEVRILMANGADVNAMDNFGVTPLHLAAYWGHFEIVEVLLKYGADVNASD 66 Query: 123 FYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVE 182 G T AA +G + ++ L K GA+VN + K G TA + + G+ + Sbjct: 67 ATGDTPLHLAAKWGYLGIVEVLLKYGADVNAQDKF----------GKTAFDISIDNGNED 116 Query: 183 VLKILLDEMGADVNACDNMGRNALIHALL 211 + +IL C N + A + +L Sbjct: 117 LAEIL----------CKNKAQQAAFYCIL 135 Score = 42.4 bits (98), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 30/86 (34%), Positives = 47/86 (54%), Gaps = 3/86 (3%) Query: 39 DLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFIL 98 ++V+ LL+ GA+VN + G TPLH A + IVE+LL++GAD + K G T F + Sbjct: 50 EIVEVLLKYGADVNASDATGD-TPLHLAAKWGYLGIVEVLLKYGADVNAQDKFGKTAFDI 108 Query: 99 AAIAGSVKLLKLFLSKGADVNECDFY 124 + G+ L ++ A + FY Sbjct: 109 SIDNGNEDLAEILCKNKA--QQAAFY 132 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 25/75 (33%), Positives = 37/75 (49%), Gaps = 7/75 (9%) Query: 257 RLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGD------LVMTARR 310 R+L ++N D+ G T L LA +I E+L K GA + D L + A+ Sbjct: 20 RILMANGADVNAMDNFGVTPLHLAAYWGHFEIVEVLLKYGADVNASDATGDTPLHLAAKW 79 Query: 311 NYDHSLVKVLLSHGA 325 Y +V+VLL +GA Sbjct: 80 GY-LGIVEVLLKYGA 93 >4NIK-A nrPDB Length = 230 Score = 66.6 bits (161), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 66/201 (32%), Positives = 98/201 (48%), Gaps = 18/201 (8%) Query: 61 TPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNE 120 T LH A +IVE LL+ G + G +P +AA AG +++K L KGA VN Sbjct: 46 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 105 Query: 121 CDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGH 180 + G T AA + + L + GAN + + + ATA+ AA KG+ Sbjct: 106 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE----------ATAMHRAAAKGN 155 Query: 181 VEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGK 240 ++++ ILL A N D G N +H L+ D+ VE LL+ GA + + + K Sbjct: 156 LKMIHILL-YYKASTNIQDTEG-NTPLH--LACDEERVEE-AKLLVSQGASIYIENKEEK 210 Query: 241 TPLILAVEKKHLGLV-QRLLE 260 TP L V K LGL+ +R++E Sbjct: 211 TP--LQVAKGGLGLILKRMVE 229 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 51/158 (32%), Positives = 79/158 (50%), Gaps = 12/158 (7%) Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 97 ++V+ LL+ G VN +++ GW+PLH A R++IV+ LL GA +NG TP Sbjct: 57 TEIVEFLLQLGVPVN-DKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLH 115 Query: 98 LAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKT 157 AA ++ + L GA+ + D Y TA AA G +K + L A+ N+ Sbjct: 116 YAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNI---- 171 Query: 158 KEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADV 195 +D E G T L A ++ VE K+L+ + GA + Sbjct: 172 -QDTE-----GNTPLHLACDEERVEEAKLLVSQ-GASI 202 Score = 60.5 bits (145), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 42/130 (32%), Positives = 66/130 (50%), Gaps = 1/130 (0%) Query: 39 DLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFIL 98 ++V+ LL GA VN + G TPLH A +R +I +LL GA+P + AT Sbjct: 91 EIVKALLGKGAQVNAVNQNG-CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHR 149 Query: 99 AAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTK 158 AA G++K++ + L A N D G T A +V+ K L +GA++ + K + Sbjct: 150 AAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEE 209 Query: 159 EDQERLRKGG 168 + ++ KGG Sbjct: 210 KTPLQVAKGG 219 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 48/168 (28%), Positives = 79/168 (47%), Gaps = 15/168 (8%) Query: 94 TPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNL 153 T A AG ++++ L G VN+ D G++ AA G+ + +K L +GA VN Sbjct: 46 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN- 104 Query: 154 RRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSS 213 + + G T L AA K E+ +LL E GA+ +A D+ A+ A Sbjct: 105 ---------AVNQNGCTPLHYAASKNRHEIAVMLL-EGGANPDAKDHYEATAMHRAAAKG 154 Query: 214 DDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQ 261 + + H+LL + A N++ G TPL LA +++ + + L+ Q Sbjct: 155 NLK----MIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQ 198 Score = 43.9 bits (102), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 52/172 (30%), Positives = 81/172 (47%), Gaps = 16/172 (9%) Query: 127 TAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKI 186 TA A G + ++FL + G VN K+D G + L AA G E++K Sbjct: 46 TALHWACSAGHTEIVEFLLQLGVPVN----DKDD------AGWSPLHIAASAGRDEIVKA 95 Query: 187 LLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILA 246 LL + GA VNA + G L +A + I +LL+ GA+ + + T + A Sbjct: 96 LLGK-GAQVNAVNQNGCTPLHYAA----SKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 150 Query: 247 VEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAS 298 K +L ++ LL + N D++G T L LA + + + A+LL +GAS Sbjct: 151 AAKGNLKMIHILLYYK-ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGAS 201 Score = 31.6 bits (70), Expect = 1.5, Method: Compositional matrix adjust. Identities = 38/134 (28%), Positives = 52/134 (38%), Gaps = 39/134 (29%) Query: 170 TALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHG 229 TAL A GH E+++ LL ++G VN D+ G + L A + D V+A LL G Sbjct: 46 TALHWACSAGHTEIVEFLL-QLGVPVNDKDDAGWSPLHIAASAGRDEIVKA----LLGKG 100 Query: 230 ADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIA 289 A VN + G TPL A K +IA Sbjct: 101 AQVNAVNQNGCTPLHYAASKNR----------------------------------HEIA 126 Query: 290 ELLCKRGASTDCGD 303 +L + GA+ D D Sbjct: 127 VMLLEGGANPDAKD 140 >6BY9-A nrPDB Length = 328 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 65/239 (27%), Positives = 112/239 (46%), Gaps = 18/239 (7%) Query: 44 LLEGGANVNFQ-EEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIA 102 +L G + NF+ E + +PLH A + DI +L++ GA+ ++ TP + AA Sbjct: 86 MLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAEN 145 Query: 103 GSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG-ANVNLRRKTKEDQ 161 ++ +K + GA V+ D G T AA G + +++L G +VN + Sbjct: 146 NHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQ------- 198 Query: 162 ERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAI 221 GG T ++ A E HV+++K+LL + G+D+N DN N +H S D I Sbjct: 199 ---DDGGWTPMIWATEYKHVDLVKLLLSK-GSDINIRDNE-ENICLHWAAFSGCVD---I 250 Query: 222 THLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLA 280 +LL D++ G +PL +A + V L ++ ++ + +G+T L A Sbjct: 251 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDS-DVTLKNKEGETPLQCA 308 Score = 62.4 bits (150), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 42/134 (31%), Positives = 74/134 (55%), Gaps = 5/134 (3%) Query: 170 TALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHG 229 + L AAE GHV++ +L+ + GA+++ C R L+ A ++++ +EA+ +L+ G Sbjct: 104 SPLHAAAEAGHVDICHMLV-QAGANIDTCSEDQRTPLMEA---AENNHLEAVKYLI-KAG 158 Query: 230 ADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIA 289 A V+ + G T L LA +K H +VQ LL +++N D G T ++ A E K + Sbjct: 159 ALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLV 218 Query: 290 ELLCKRGASTDCGD 303 +LL +G+ + D Sbjct: 219 KLLLSKGSDINIRD 232 Score = 56.6 bits (135), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 36/122 (29%), Positives = 62/122 (50%), Gaps = 2/122 (1%) Query: 39 DLVQQLLEGG-ANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 97 ++VQ LL G +VN Q++ GGWTP+ A + D+V+LLL G+D +R Sbjct: 182 EVVQYLLSNGQMDVNCQDD-GGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLH 240 Query: 98 LAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKT 157 AA +G V + ++ L+ D++ + +G + AA + + R ++V L+ K Sbjct: 241 WAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKE 300 Query: 158 KE 159 E Sbjct: 301 GE 302 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 1/110 (0%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 +I A + + VDLV+ LL G+++N ++ E LH A DI E+LL D Sbjct: 206 MIWATEYKHVDLVKLLLSKGSDINIRDNEENIC-LHWAAFSGCVDIAEILLAAKCDLHAV 264 Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKV 138 +G +P +AA + LFLS+ +DV + G T A++ +V Sbjct: 265 NIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQV 314 >2DWZ-A nrPDB Length = 231 Score = 63.2 bits (152), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 67/203 (33%), Positives = 97/203 (47%), Gaps = 18/203 (8%) Query: 61 TPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNE 120 T LH A +IVE LL+ G + G +P +AA AG +++K L KGA VN Sbjct: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLVKGAHVNA 101 Query: 121 CDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGH 180 + G T AA + + L + GAN + + ATA+ AA KG+ Sbjct: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYD----------ATAMHRAAAKGN 151 Query: 181 VEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGK 240 ++++ ILL A N D G N +H L+ D+ VE L+ GA + + + K Sbjct: 152 LKMVHILL-FYKASTNIQDTEG-NTPLH--LACDEERVEE-AKFLVTQGASIYIENKEEK 206 Query: 241 TPLILAVEKKHLGLV-QRLLEQE 262 TPL +A K LGL+ +RL E E Sbjct: 207 TPLQVA--KGGLGLILKRLAEGE 227 Score = 62.8 bits (151), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 51/158 (32%), Positives = 78/158 (49%), Gaps = 12/158 (7%) Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 97 ++V+ LL+ G VN +++ GW+PLH A R++IV+ LL GA +NG TP Sbjct: 53 TEIVEFLLQLGVPVN-DKDDAGWSPLHIAASAGRDEIVKALLVKGAHVNAVNQNGCTPLH 111 Query: 98 LAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKT 157 AA ++ + L GA+ + D Y TA AA G +K + L A+ N+ Sbjct: 112 YAASKNRHEIAVMLLEGGANPDAKDHYDATAMHRAAAKGNLKMVHILLFYKASTNI---- 167 Query: 158 KEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADV 195 +D E G T L A ++ VE K L+ + GA + Sbjct: 168 -QDTE-----GNTPLHLACDEERVEEAKFLVTQ-GASI 198 Score = 62.4 bits (150), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 43/130 (33%), Positives = 68/130 (52%), Gaps = 1/130 (0%) Query: 39 DLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFIL 98 ++V+ LL GA+VN + G TPLH A +R +I +LL GA+P + AT Sbjct: 87 EIVKALLVKGAHVNAVNQNG-CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYDATAMHR 145 Query: 99 AAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTK 158 AA G++K++ + L A N D G T A +V+ KFL +GA++ + K + Sbjct: 146 AAAKGNLKMVHILLFYKASTNIQDTEGNTPLHLACDEERVEEAKFLVTQGASIYIENKEE 205 Query: 159 EDQERLRKGG 168 + ++ KGG Sbjct: 206 KTPLQVAKGG 215 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 52/172 (30%), Positives = 80/172 (46%), Gaps = 16/172 (9%) Query: 127 TAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKI 186 TA A G + ++FL + G VN K+D G + L AA G E++K Sbjct: 42 TALHWACSAGHTEIVEFLLQLGVPVN----DKDD------AGWSPLHIAASAGRDEIVKA 91 Query: 187 LLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILA 246 LL + GA VNA + G L +A + I +LL+ GA+ + + T + A Sbjct: 92 LLVK-GAHVNAVNQNGCTPLHYAA----SKNRHEIAVMLLEGGANPDAKDHYDATAMHRA 146 Query: 247 VEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAS 298 K +L +V LL + N D++G T L LA + + + A+ L +GAS Sbjct: 147 AAKGNLKMVHILLFYK-ASTNIQDTEGNTPLHLACDEERVEEAKFLVTQGAS 197 >4OT9-A nrPDB Length = 359 Score = 62.8 bits (151), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 63/190 (33%), Positives = 87/190 (45%), Gaps = 20/190 (10%) Query: 61 TPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILA--AIAGSVKLLKLFLSKGAD- 117 TPLH AV + +V LLR GADP L ++G + LA A AG+ +LL+ L GA Sbjct: 123 TPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPA 182 Query: 118 ----VNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALM 173 ++ DF G A + L L GA V E E R+GG TAL Sbjct: 183 VPQLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEV-------EATE--RQGGRTALH 233 Query: 174 DAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVN 233 A E + ++ L+ ++ A+VNA G N +H + +T LLL GAD++ Sbjct: 234 LATEMEELGLVTHLVTKLRANVNARTFAG-NTPLHL---AAGLGYPTLTRLLLKAGADIH 289 Query: 234 VRGERGKTPL 243 E PL Sbjct: 290 AENEEPLCPL 299 Score = 58.5 bits (140), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 66/228 (28%), Positives = 103/228 (45%), Gaps = 16/228 (7%) Query: 41 VQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVE---LLLRHGAD-PVLRKKN--GAT 94 + LL G ++ ++E G TPLH A+ + ++E ++ H D V+ N T Sbjct: 64 ARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQT 123 Query: 95 PFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEA--AVYGKVKALKFLYKRGANVN 152 P LA I G ++ L GAD D +G +A A A G + L+ L + GA Sbjct: 124 PLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAV 183 Query: 153 LRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLS 212 + D E G + A E L +L+D GA+V A + G +H L+ Sbjct: 184 PQLLHMPDFE-----GLYPVHLAVRARSPECLDLLVDS-GAEVEATERQGGRTALH--LA 235 Query: 213 SDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLE 260 ++ ++ +THL+ A+VN R G TPL LA + L + LL+ Sbjct: 236 TEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLK 283 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 35/94 (37%), Positives = 49/94 (52%), Gaps = 4/94 (4%) Query: 27 HLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIV-ELLLRHGADP 85 HL ++A E +DL L++ GA V E +GG T LH A +M +V L+ + A+ Sbjct: 199 HLAVRARSPECLDL---LVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANV 255 Query: 86 VLRKKNGATPFILAAIAGSVKLLKLFLSKGADVN 119 R G TP LAA G L +L L GAD++ Sbjct: 256 NARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIH 289 >2KXP-C nrPDB Length = 118 Score = 59.3 bits (142), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 44/110 (40%), Positives = 59/110 (53%), Gaps = 2/110 (1%) Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91 A++N D+D V+ + G +VN + EGG PLH A + +I+E LL GAD K+ Sbjct: 9 ALKNGDLDEVKDYVAKGEDVN-RTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKH 67 Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKAL 141 TP + A G V +KL LSKGAD G TA +EA +KAL Sbjct: 68 HITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTA-LEATDNQAIKAL 116 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 37/124 (29%), Positives = 57/124 (45%), Gaps = 22/124 (17%) Query: 96 FILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR 155 F+ A G + +K +++KG DVN G AA G+++ L+FL +GA++N Sbjct: 6 FMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPD 65 Query: 156 KTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGAD-----------VNACDNMGRN 204 K T L+ A +GHV +K+LL + GAD + A DN Sbjct: 66 KHH----------ITPLLSAVYEGHVSCVKLLLSK-GADKTVKGPDGLTALEATDNQAIK 114 Query: 205 ALIH 208 AL+ Sbjct: 115 ALLQ 118 Score = 33.5 bits (75), Expect = 0.36, Method: Compositional matrix adjust. Identities = 26/70 (37%), Positives = 37/70 (52%), Gaps = 4/70 (5%) Query: 192 GADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKH 251 G DVN GR L +A +D +E + LLL GAD+N + TPL+ AV + H Sbjct: 25 GEDVNRTLEGGRKPLHYA---ADCGQLEILEFLLL-KGADINAPDKHHITPLLSAVYEGH 80 Query: 252 LGLVQRLLEQ 261 + V+ LL + Sbjct: 81 VSCVKLLLSK 90 >3ZKJ-A nrPDB Length = 261 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 62/257 (24%), Positives = 100/257 (38%), Gaps = 54/257 (21%) Query: 60 WTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVN 119 W+P+H A + + L+ G + + +P A + G + +K+ L GA VN Sbjct: 4 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 63 Query: 120 ECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKG 179 T A V G + L + GA+V A+ + +AA +G Sbjct: 64 GVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDL-----------ASPIHEAARRG 112 Query: 180 HVEVLKILLDEMGADVN------------ACDNMGRNALIHALLSS---------DDSDV 218 HVE + L+ G +++ AC+N R A + LL S DS + Sbjct: 113 HVECVNSLI-AYGGNIDHKISHLGTPLYLACENQQR-ACVKKLLESGADVNQGKGQDSPL 170 Query: 219 EAITH--------LLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTD 270 A+ LL+D GAD + GK P+ L + L Q LE+E Sbjct: 171 HAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPES--PLAQLFLERE-------- 220 Query: 271 SDGKTALLLAVELKLKK 287 G +L+ L+++K Sbjct: 221 --GPPSLMQLCRLRIRK 235 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 28/86 (32%), Positives = 45/86 (52%), Gaps = 4/86 (4%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 L A +N+ V++LLE GA+VN + +G +PLH + + E++ LL+ GAD + Sbjct: 138 LYLACENQQRACVKKLLESGADVN--QGKGQDSPLHAVARTASEELACLLMDFGADTQAK 195 Query: 89 KKNGATPFILAAIAGSVKLLKLFLSK 114 G P L + L +LFL + Sbjct: 196 NAEGKRPVEL--VPPESPLAQLFLER 219 Score = 36.6 bits (83), Expect = 0.042, Method: Compositional matrix adjust. Identities = 28/92 (30%), Positives = 42/92 (45%), Gaps = 2/92 (2%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 L A + D V LL+ GA+V Q E +P+H A + + V L+ +G + + Sbjct: 73 LFNACVSGSWDCVNLLLQHGASV--QPESDLASPIHEAARRGHVECVNSLIAYGGNIDHK 130 Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNE 120 + TP LA +K L GADVN+ Sbjct: 131 ISHLGTPLYLACENQQRACVKKLLESGADVNQ 162 >6AUN-A nrPDB Length = 752 Score = 57.0 bits (136), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 60/235 (25%), Positives = 110/235 (46%), Gaps = 20/235 (8%) Query: 59 GWTPLHNAVQMSREDIVELLLRHGADPVLR-KKNGATPFILAAIAGSVKLLKLFLSKGAD 117 G T H AVQ +++LL ++ + + + K G TP LA G +++++ L A Sbjct: 186 GETAFHYAVQGDNSQVLQLLGKNASAGLNQVNKQGLTPLHLACQMGKQEMVRVLLLCNAR 245 Query: 118 VNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAE 177 N GF A+KF K A + + + + + + GA+ L A Sbjct: 246 CNVMGPSGFPIH---------TAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK- 295 Query: 178 KGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGE 237 + E+ ++LL G DV++ G AL H + + D + LL +GA+ GE Sbjct: 296 --NAEMARMLLKR-GCDVDSTSAAGNTAL-HVAVMRNRFDCVMV---LLTYGANAGTPGE 348 Query: 238 RGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELL 292 G TPL LA+ K ++ +++ L+ E++ + G+T +A ++ K++ +L+ Sbjct: 349 HGNTPLHLAISKDNMEMIKALI-VFGAEVDTPNDFGETPAFMASKIS-KQLQDLM 401 Score = 47.4 bits (111), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 61/107 (57%), Gaps = 2/107 (1%) Query: 36 EDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATP 95 ++ ++ + LL+ G +V+ G T LH AV +R D V +LL +GA+ ++G TP Sbjct: 295 KNAEMARMLLKRGCDVDSTSAAGN-TALHVAVMRNRFDCVMVLLTYGANAGTPGEHGNTP 353 Query: 96 FILAAIAGSVKLLKLFLSKGADVNECDFYGFT-AFMEAAVYGKVKAL 141 LA +++++K + GA+V+ + +G T AFM + + +++ L Sbjct: 354 LHLAISKDNMEMIKALIVFGAEVDTPNDFGETPAFMASKISKQLQDL 400 Score = 34.3 bits (77), Expect = 0.19, Method: Compositional matrix adjust. Identities = 30/92 (32%), Positives = 44/92 (47%), Gaps = 3/92 (3%) Query: 168 GATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLD 227 G T L A KG E+L L+ A ++ DN G A H + D+S V + L + Sbjct: 152 GCTPLHLACRKGDSEILVELVQYCHAQMDVTDNKGETAF-HYAVQGDNSQV--LQLLGKN 208 Query: 228 HGADVNVRGERGKTPLILAVEKKHLGLVQRLL 259 A +N ++G TPL LA + +V+ LL Sbjct: 209 ASAGLNQVNKQGLTPLHLACQMGKQEMVRVLL 240 Score = 33.5 bits (75), Expect = 0.31, Method: Compositional matrix adjust. Identities = 20/62 (32%), Positives = 35/62 (56%) Query: 237 ERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRG 296 E G TPL LA K ++ L++ H +++ TD+ G+TA AV+ ++ +LL K Sbjct: 150 EEGCTPLHLACRKGDSEILVELVQYCHAQMDVTDNKGETAFHYAVQGDNSQVLQLLGKNA 209 Query: 297 AS 298 ++ Sbjct: 210 SA 211 >5GP7-A nrPDB Length = 169 Score = 56.6 bits (135), Expect = 4e-08, Method: Composition-based stats. Identities = 39/116 (33%), Positives = 55/116 (47%), Gaps = 3/116 (2%) Query: 50 NVNFQEEEG-GWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLL 108 N+N ++ +G TPLH A + ++ E LL HGAD + K G P AA G V + Sbjct: 33 NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIA 92 Query: 109 KLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERL 164 L + VN D + FT EAA G+ + L GA+ + K +E Q L Sbjct: 93 ALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTM--KNQEGQTPL 146 Score = 50.8 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 31/81 (38%), Positives = 44/81 (54%), Gaps = 1/81 (1%) Query: 37 DVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPF 96 ++++ + LLE GA+VN Q ++GG PLHNA DI LL+++ K TP Sbjct: 55 NLEVAEYLLEHGADVNAQ-DKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 113 Query: 97 ILAAIAGSVKLLKLFLSKGAD 117 AA G +L L L+ GAD Sbjct: 114 HEAAQKGRTQLCALLLAHGAD 134 Score = 48.5 bits (114), Expect = 1e-05, Method: Composition-based stats. Identities = 35/115 (30%), Positives = 53/115 (46%), Gaps = 15/115 (13%) Query: 132 AAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEM 191 AA Y ++ ++L + GA+VN + K GG L +AA GHV++ +L+ Sbjct: 50 AAGYNNLEVAEYLLEHGADVNAQDK----------GGLIPLHNAASYGHVDIAALLIK-- 97 Query: 192 GADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILA 246 N C N L + + LLL HGAD ++ + G+TPL LA Sbjct: 98 ---YNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 149 Score = 48.5 bits (114), Expect = 1e-05, Method: Composition-based stats. Identities = 25/62 (40%), Positives = 35/62 (56%), Gaps = 1/62 (1%) Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 97 VD+ L++ VN ++ +TPLH A Q R + LLL HGADP ++ + G TP Sbjct: 89 VDIAALLIKYNTCVN-ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLD 147 Query: 98 LA 99 LA Sbjct: 148 LA 149 Score = 46.2 bits (108), Expect = 5e-05, Method: Composition-based stats. Identities = 44/132 (33%), Positives = 69/132 (52%), Gaps = 9/132 (6%) Query: 168 GATALMDAAEKGHV-EVLKILLDEMGADVNACDNMGRNAL-IHALLSSDDSDVEAITHLL 225 G AL+DAA+KG + V K+ E ++N D GRN+ +H L++ +++E + L Sbjct: 9 GDAALLDAAKKGCLARVQKLCTPE---NINCRDTQGRNSTPLH--LAAGYNNLE-VAEYL 62 Query: 226 LDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKL 285 L+HGADVN + + G PL A H+ + LL + + +N TD T L A + Sbjct: 63 LEHGADVNAQDKGGLIPLHNAASYGHVDIAA-LLIKYNTCVNATDKWAFTPLHEAAQKGR 121 Query: 286 KKIAELLCKRGA 297 ++ LL GA Sbjct: 122 TQLCALLLAHGA 133 Score = 35.4 bits (80), Expect = 0.082, Method: Composition-based stats. Identities = 23/66 (34%), Positives = 31/66 (46%) Query: 238 RGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGA 297 RG L+ A +K L VQ+L E+I DT T L LA ++AE L + GA Sbjct: 8 RGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGA 67 Query: 298 STDCGD 303 + D Sbjct: 68 DVNAQD 73 >3VN9-A nrPDB Length = 340 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 51/211 (24%), Positives = 85/211 (40%), Gaps = 39/211 (18%) Query: 418 VTFYGSESHRGHLFVCVTLCEQTLEACLD--VHRGEDVENEEDEFARNVLSSIFKAVQEL 475 VTFYG+ G +++C+ L + +L+ + +G+ + ED + + SI KA++ L Sbjct: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIP--EDILGK-IAVSIVKALEHL 169 Query: 476 HLSCGYTHQDLQPQNILIDSKKAAHLADFD----------KSIKWAGDP----------- 514 H H+D++P N+LI++ + DF K+I P Sbjct: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPEL 229 Query: 515 ----QEVKRDLEDLGRLVL------YVVKKGSISFEDLKAQSNEEVVQLSPDE---ETKD 561 VK D+ LG ++ + F+ LK E QL D+ E D Sbjct: 230 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVD 289 Query: 562 LIHRLFHPGEHVRDCLSDLLGHPFFWTWESR 592 + R +L+ HPFF ES+ Sbjct: 290 FTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 >3FME-A nrPDB Length = 290 Score = 53.1 bits (126), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 51/211 (24%), Positives = 85/211 (40%), Gaps = 39/211 (18%) Query: 418 VTFYGSESHRGHLFVCVTLCEQTLEACLD--VHRGEDVENEEDEFARNVLSSIFKAVQEL 475 VTFYG+ G +++C+ L + +L+ + +G+ + ED + + SI KA++ L Sbjct: 69 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIP--EDILGK-IAVSIVKALEHL 125 Query: 476 HLSCGYTHQDLQPQNILIDSKKAAHLADF--------------DKSIKWAGDPQ------ 515 H H+D++P N+LI++ + DF D K P+ Sbjct: 126 HSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERINPEL 185 Query: 516 -----EVKRDLEDLGRLVL------YVVKKGSISFEDLKAQSNEEVVQLSPDE---ETKD 561 VK D+ LG ++ + F+ LK E QL D+ E D Sbjct: 186 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVD 245 Query: 562 LIHRLFHPGEHVRDCLSDLLGHPFFWTWESR 592 + R +L+ HPFF ES+ Sbjct: 246 FTSQCLKKNSKERPTYPELMQHPFFTLHESK 276 >1WG0-A nrPDB Length = 243 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 98/219 (44%), Gaps = 18/219 (8%) Query: 26 NHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADP 85 N+ L +A + VQ+LL ++ Q+++ G PLH +V +I LL + Sbjct: 3 NYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENV 62 Query: 86 VL---RKKNGATPFILAAIAGSVKLLKLFLSKG--ADVNECDFYGFTAFMEAAVYGKVKA 140 L +G TPF +A G+++++K + D+N+ G T A + Sbjct: 63 NLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEV 122 Query: 141 LKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDN 200 +FL + GA+V R K K +Q L + AA G ++++++L + VN D Sbjct: 123 SQFLIENGASV--RIKDKFNQIPLHR--------AASVGSLKLIELLCGLGKSAVNWQDK 172 Query: 201 MGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERG 239 G L HAL +A L+ +GA+ ++ +G Sbjct: 173 QGWTPLFHALAEGHG---DAAVLLVEKYGAEYDLVDNKG 208 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 46/167 (27%), Positives = 71/167 (42%), Gaps = 15/167 (8%) Query: 44 LLEGGANVNFQE--EEGGWTPLHNAVQMSREDIVELLLRHGADPVLRK--KNGATPFILA 99 LL NVN + ++ GWTP H A + ++V+ L P L K G T LA Sbjct: 55 LLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLA 114 Query: 100 AIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG-ANVNLRRKTK 158 ++ + + GA V D + AA G +K ++ L G + VN + K Sbjct: 115 VGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQ- 173 Query: 159 EDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNA 205 G T L A +GH + +L+++ GA+ + DN G A Sbjct: 174 ---------GWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKA 211 Score = 32.0 bits (71), Expect = 0.98, Method: Compositional matrix adjust. Identities = 26/87 (29%), Positives = 43/87 (49%), Gaps = 4/87 (4%) Query: 221 ITHLLLDHGADVNV---RGERGKTPLILAVEKKHLGLVQRLLEQE-HIEINDTDSDGKTA 276 IT LL +VN+ + G TP +A +L +V+ L ++ ++N + G T Sbjct: 51 ITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTC 110 Query: 277 LLLAVELKLKKIAELLCKRGASTDCGD 303 L LAV K ++++ L + GAS D Sbjct: 111 LHLAVGKKWFEVSQFLIENGASVRIKD 137 >3COM-A nrPDB Length = 314 Score = 48.9 bits (115), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 40/139 (28%), Positives = 71/139 (51%), Gaps = 9/139 (6%) Query: 370 KIADTSEGGIYLGFYEK--QEVAVKTFCEGSPRAQ--REVSCLQSSRENSHLVTFYGSES 425 K+ + S G +Y +++ Q VA+K S + +E+S +Q ++ H+V +YGS Sbjct: 36 KLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQC-DSPHVVKYYGSYF 94 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 L++ + C + D+ R + EDE A +L S K ++ LH H+D Sbjct: 95 KNTDLWIVMEYCGAG--SVSDIIRLRNKTLTEDEIA-TILQSTLKGLEYLHF-MRKIHRD 150 Query: 486 LQPQNILIDSKKAAHLADF 504 ++ NIL++++ A LADF Sbjct: 151 IKAGNILLNTEGHAKLADF 169 >5D68-A nrPDB Length = 486 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 36/113 (31%), Positives = 53/113 (46%), Gaps = 11/113 (9%) Query: 95 PFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG-ANVNL 153 P +A G +LL LS+ VN+ D + A YGKV+A + L ++G N NL Sbjct: 41 PLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNL 100 Query: 154 RRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNAL 206 L ++ L AA GH E+++ILL+ D + D GR+ L Sbjct: 101 ----------LNGQLSSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPL 143 >4CQG-A nrPDB Length = 331 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 35/115 (30%), Positives = 53/115 (46%), Gaps = 6/115 (5%) Query: 399 PRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEED 458 PR + E+ L+S R + H+ Y + +F+ + C D +D +EE+ Sbjct: 52 PRVKTEIDALKSLR-HQHICQLYHVLETKNKIFMVLEYCPGG--ELFDYIISQDRLSEEE 108 Query: 459 EFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD 513 R V I AV +H S GY H+DL+P+N+L D L DF K G+ Sbjct: 109 --TRVVFRQILSAVAYVH-SQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGN 160 >3DB8-A nrPDB Length = 317 Score = 45.8 bits (107), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 54/258 (20%), Positives = 103/258 (39%), Gaps = 44/258 (17%) Query: 369 YKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVS---CLQSSRENSHLVTFYGSES 425 Y+I D ++ G + + +K P + ++S + S +N H+V F+G Sbjct: 59 YEITDMDTKEVFAGKVVPKSMLLK------PHQKEKMSTEIAIHKSLDNPHVVGFHGFFE 112 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 ++V + +C + + L++H+ E + AR + + VQ LH + H+D Sbjct: 113 DDDFVYVVLEICRR--RSLLELHKRRKAVTEPE--ARYFMRQTIQGVQYLH-NNRVIHRD 167 Query: 486 LQPQNILIDSKKAAHLADFDKSIK----------WAGDPQEV------------KRDLED 523 L+ N+ ++ + DF + K G P + + D+ Sbjct: 168 LKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCKKGHSFEVDIWS 227 Query: 524 LGRLVLYVVKKGSISFED-------LKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDC 576 LG +LY + G FE ++ + NE V + LI R+ H +R Sbjct: 228 LG-CILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALIRRMLHADPTLRPS 286 Query: 577 LSDLLGHPFFWTWESRYR 594 +++LL FF + + R Sbjct: 287 VAELLTDEFFTSGYAPMR 304 >3M42-A nrPDB Length = 299 Score = 45.4 bits (106), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 58/250 (23%), Positives = 105/250 (42%), Gaps = 32/250 (12%) Query: 365 IDEKYKIADTSEG----GIYLGFYEK--QEVAVKTFCEGSPRAQREVSCLQSSRENSHLV 418 I + YK+ G G L + K QE + P+A+REV + + H+V Sbjct: 15 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIV 74 Query: 419 TFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENE--EDEFARNVLSSIFKAVQELH 476 + C+ + + L+ R +D ++ + A ++ SI +A+Q LH Sbjct: 75 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 477 LSCGYTHQDLQPQNILIDSKKA---AHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVK 533 S H+D++P+N+L SK+ L DF + + G+ + D+ LG +++Y++ Sbjct: 135 -SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGEKYDKSCDMWSLG-VIMYILL 192 Query: 534 KGSISFED---------LKAQ--------SNEEVVQLSPDEETKDLIHRLFHPGEHVRDC 576 G F +K + N E ++S EE K LI L R Sbjct: 193 CGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS--EEVKMLIRNLLKTEPTQRMT 250 Query: 577 LSDLLGHPFF 586 +++ + HP+ Sbjct: 251 ITEFMNHPWI 260 >4D2V-A nrPDB Length = 356 Score = 45.4 bits (106), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 53/221 (23%), Positives = 89/221 (40%), Gaps = 42/221 (19%) Query: 399 PRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEED 458 PR + E+ L++ R + H+ Y +F+ + C D +D +EE+ Sbjct: 72 PRIKTEIEALKNLR-HQHICQLYHVLETANKIFMVLEYCPGG--ELFDYIISQDRLSEEE 128 Query: 459 EFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD----- 513 R V I AV +H S GY H+DL+P+N+L D L DF K G+ Sbjct: 129 --TRVVFRQIVSAVAYVH-SQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHL 185 Query: 514 -----------PQEVK--------RDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQ-- 552 P+ ++ D+ +G ++LYV+ G + F+D A + + Sbjct: 186 QACCGALAYAAPELIQGKSYLGSEADVWSMG-ILLYVLMCGFLPFDDDTAAALVAKIMRG 244 Query: 553 -------LSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 LSP L+ ++ R + +LL HP+ Sbjct: 245 KYDVPKWLSPSSIL--LLQQMLQVDPKKRISMKNLLNHPWI 283 >6GU6-A nrPDB Length = 302 Score = 44.7 bits (104), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 42/144 (29%), Positives = 69/144 (47%), Gaps = 14/144 (9%) Query: 370 KIADTSEGGIYLGFYEK--QEVAVKTFC-----EGSPR-AQREVSCLQSSRENSHLVTFY 421 KI + + G +Y G ++ Q VA+K EG P A RE+S L+ R + ++V+ Sbjct: 14 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR-HPNIVSLQ 72 Query: 422 GSESHRGHLFVCVTLCEQTLEACLD-VHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG 480 L++ L+ LD + G+ +++ ++ L I + + H S Sbjct: 73 DVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSS---LVKSYLYQILQGIVFCH-SRR 128 Query: 481 YTHQDLQPQNILIDSKKAAHLADF 504 H+DL+PQN+LID K LADF Sbjct: 129 VLHRDLKPQNLLIDDKGTIKLADF 152 >1BD8-A nrPDB Length = 156 Score = 43.9 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 28/85 (32%), Positives = 47/85 (55%), Gaps = 2/85 (2%) Query: 43 QLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIA 102 +LL+ GA+ N Q+ G +P+H+A + D +++L+ HGAD + GA P LA Sbjct: 53 ELLKQGASPNVQDTSGT-SPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQE 111 Query: 103 GSVKLLKLFLSKGADVNECDFYGFT 127 G ++ FL+ +D++ D G T Sbjct: 112 GHTAVVS-FLAAESDLHRRDARGLT 135 Score = 39.7 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 34/114 (29%), Positives = 50/114 (43%), Gaps = 11/114 (9%) Query: 78 LLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGK 137 LL+ GA P ++ +G +P AA G + LK+ + GADVN D G A G Sbjct: 54 LLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGH 113 Query: 138 VKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEM 191 + FL A +L R+ G T L A ++G +++ IL M Sbjct: 114 TAVVSFL---AAESDLHRRDAR--------GLTPLELALQRGAQDLVDILQGHM 156 Score = 39.3 bits (90), Expect = 0.007, Method: Composition-based stats. Identities = 23/69 (33%), Positives = 41/69 (59%), Gaps = 2/69 (2%) Query: 224 LLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVEL 283 +L++HGADVNV G P+ LAV++ H +V L + +++ D+ G T L LA++ Sbjct: 86 VLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAES--DLHRRDARGLTPLELALQR 143 Query: 284 KLKKIAELL 292 + + ++L Sbjct: 144 GAQDLVDIL 152 Score = 35.4 bits (80), Expect = 0.093, Method: Composition-based stats. Identities = 39/139 (28%), Positives = 60/139 (43%), Gaps = 13/139 (9%) Query: 72 EDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFME 131 +++ LL R P + G T + + L+L L +GA N D G + + Sbjct: 16 QEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL-LKQGASPNVQDTSGTSPVHD 74 Query: 132 AAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEM 191 AA G + LK L + GA+VN+ T GA + A ++GH V+ L E Sbjct: 75 AARTGFLDTLKVLVEHGADVNVPDGT----------GALPIHLAVQEGHTAVVSFLAAE- 123 Query: 192 GADVNACDNMGRNALIHAL 210 +D++ D G L AL Sbjct: 124 -SDLHRRDARGLTPLELAL 141 >3ALO-A nrPDB Length = 327 Score = 43.9 bits (102), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 53/228 (23%), Positives = 91/228 (39%), Gaps = 41/228 (17%) Query: 404 EVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLD-VHRGEDVENEEDEFAR 462 ++ + S + ++V FYG+ G ++C+ L + + V+ D E+ + Sbjct: 70 DLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGK 129 Query: 463 NVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS---------IKWAG- 512 L+++ KA+ L + H+D++P NIL+D L DF S + AG Sbjct: 130 ITLATV-KALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGC 188 Query: 513 ---------DPQ------EVKRDLEDLGRLVLYVVKKGSIS-------FEDLKAQSNEEV 550 DP +V+ D+ LG + LY + G F+ L + Sbjct: 189 RPYMAPERIDPSASRQGYDVRSDVWSLG-ITLYELATGRFPYPKWNSVFDQLTQVVKGDP 247 Query: 551 VQLSPDEETK------DLIHRLFHPGEHVRDCLSDLLGHPFFWTWESR 592 QLS EE + + ++ E R +LL HPF +E R Sbjct: 248 PQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEER 295 >6AO5-A nrPDB Length = 362 Score = 43.9 bits (102), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 37/139 (26%), Positives = 71/139 (51%), Gaps = 9/139 (6%) Query: 370 KIADTSEGGIYLGFYEK--QEVAVKTFCEGSPRAQ--REVSCLQSSRENSHLVTFYGSES 425 K+ + S G ++ +++ Q VA+K S + +E+S +Q ++ ++V +YGS Sbjct: 17 KLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQC-DSPYVVKYYGSYF 75 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 L++ + C + D+ R + EDE A +L S K ++ LH H++ Sbjct: 76 KNTDLWIVMEYCGAG--SVSDIIRLRNKTLIEDEIA-TILKSTLKGLEYLHF-MRKIHRN 131 Query: 486 LQPQNILIDSKKAAHLADF 504 ++ NIL++++ A LADF Sbjct: 132 IKAGNILLNTEGHAKLADF 150 >4D28-A nrPDB Length = 446 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 49/215 (22%), Positives = 86/215 (40%), Gaps = 37/215 (17%) Query: 402 QREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFA 461 +RE+S ++ R + ++V Y + + +++ + VH+G E+E + Sbjct: 57 KREISIMKIVR-HPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDE----S 111 Query: 462 RNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI----------KWA 511 R + AV H S G H+DL+P+N+L+D+ ++DF S Sbjct: 112 RKYFQQLVDAVAHCH-SKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTC 170 Query: 512 GDPQEV-------------KRDLEDLGRLVLYVVKKGSISFED-----LKAQSNEEVVQL 553 G P V D+ G ++L+V+ G + F + L + N Sbjct: 171 GTPNYVAPEVLSGQGYDGSAADIWSCG-VILFVILAGYLPFSETDLPGLYRKINAAEFDC 229 Query: 554 SP--DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 P E K LIHR+ P R + + P+F Sbjct: 230 PPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 >1ZXE-A nrPDB Length = 303 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 23/78 (29%), Positives = 40/78 (51%), Gaps = 4/78 (5%) Query: 427 RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDL 486 + LF+ + CE D+ E++ + DE+ R + I +A+ +H S G H++L Sbjct: 87 KSTLFIQMEYCEN--RTLYDLIHSENLNQQRDEYWR-LFRQILEALSYIH-SQGIIHRNL 142 Query: 487 QPQNILIDSKKAAHLADF 504 +P NI ID + + DF Sbjct: 143 KPMNIFIDESRNVKIGDF 160 >2VD5-A nrPDB Length = 412 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 22/55 (40%), Positives = 30/55 (54%), Gaps = 1/55 (1%) Query: 459 EFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD 513 E AR L+ I A+ +H GY H+D++P NIL+D LADF +K D Sbjct: 162 EMARFYLAEIVMAIDSVH-RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRAD 215 >3T9K-A nrPDB Length = 390 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 28/84 (33%), Positives = 37/84 (44%), Gaps = 2/84 (2%) Query: 79 LRHGADP--VLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYG 136 L HGAD V ++ ATP I A A S+ + L GA+VN+ D G A + G Sbjct: 220 LAHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILG 279 Query: 137 KVKALKFLYKRGANVNLRRKTKED 160 KRGA++ R D Sbjct: 280 HTGLACLFLKRGADLGARDSEGRD 303 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 43/143 (30%), Positives = 64/143 (44%), Gaps = 6/143 (4%) Query: 152 NLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEM--GADVNACDNMGRNALIHA 209 +LR K + E L AL+ A GH L + D + GADVN + NA Sbjct: 182 DLRSKPEPPSEDLGSLHPGALLFRA-SGHPPSLPTMADALAHGADVNWVNGGQDNAT--P 238 Query: 210 LLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDT 269 L+ + ++ LL +GA+VN G+ PL A H GL L++ ++ Sbjct: 239 LIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKR-GADLGAR 297 Query: 270 DSDGKTALLLAVELKLKKIAELL 292 DS+G+ L +A+E I LL Sbjct: 298 DSEGRDPLTIAMETANADIVTLL 320 Score = 37.0 bits (84), Expect = 0.033, Method: Compositional matrix adjust. Identities = 36/109 (33%), Positives = 46/109 (42%), Gaps = 4/109 (3%) Query: 45 LEGGANVNF-QEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAG 103 L GA+VN+ + TPL A + E LL++GA+ G P A I G Sbjct: 220 LAHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILG 279 Query: 104 SVKLLKLFLSKGADVNECDFYG---FTAFMEAAVYGKVKALKFLYKRGA 149 L LFL +GAD+ D G T ME A V L+ R A Sbjct: 280 HTGLACLFLKRGADLGARDSEGRDPLTIAMETANADIVTLLRLAKMREA 328 >6E2G-A nrPDB Length = 727 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 49/166 (29%), Positives = 77/166 (46%), Gaps = 16/166 (9%) Query: 88 RKKNGATPFILAAIAGSVK-LLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYK 146 +K+ +P +LAA +V+ L+KL +G +V++ G TA AA+Y ++A L + Sbjct: 41 QKRIWESPLLLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLME 100 Query: 147 RGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNA-----CDNM 201 + T E E G TAL A +V +++ LL GA V+A + Sbjct: 101 AAPELVFEPMTSELYE-----GQTALHIAVINQNVNLVRALLAR-GASVSARATGSVFHY 154 Query: 202 GRNALI----HALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPL 243 + LI H L + E I LL++HGAD+ + G T L Sbjct: 155 RPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVL 200 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 51/185 (27%), Positives = 84/185 (45%), Gaps = 23/185 (12%) Query: 125 GFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQER---LRKGGATALMDAAEKGHV 181 G TA A + V ++ L RGA+V+ R R L G L AA G Sbjct: 117 GQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGSE 176 Query: 182 EVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLL-----DHGADVN-VR 235 E++++L+ E GAD+ A D++G L +L + + + +LLL DH + V Sbjct: 177 EIVRLLI-EHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGGDHLKSLELVP 235 Query: 236 GERGKTPLILAVEKKHLGLVQRLLE-QEHIE------------INDTDSDGKTALLLAVE 282 +G TP LA + ++ + Q L++ ++HI+ + + DS G LL + Sbjct: 236 NNQGLTPFKLAGVEGNIVMFQHLMQKRKHIQWTYGPLTSTLYDLTEIDSSGDDQSLLELI 295 Query: 283 LKLKK 287 + KK Sbjct: 296 VTTKK 300 Score = 34.7 bits (78), Expect = 0.16, Method: Compositional matrix adjust. Identities = 24/65 (36%), Positives = 34/65 (52%), Gaps = 12/65 (18%) Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEG------------GWTPLHNAVQMSREDIVELLL 79 AV N++V+LV+ LL GA+V+ + G PL A + E+IV LL+ Sbjct: 124 AVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGSEEIVRLLI 183 Query: 80 RHGAD 84 HGAD Sbjct: 184 EHGAD 188 Score = 33.1 bits (74), Expect = 0.40, Method: Compositional matrix adjust. Identities = 27/95 (28%), Positives = 49/95 (51%), Gaps = 4/95 (4%) Query: 210 LLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDT 269 LL++ +++V+A+ LL G +V+ +G G+T L +A +L L+E + + Sbjct: 50 LLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLMEAAPELVFEP 109 Query: 270 DS----DGKTALLLAVELKLKKIAELLCKRGASTD 300 + +G+TAL +AV + + L RGAS Sbjct: 110 MTSELYEGQTALHIAVINQNVNLVRALLARGASVS 144 >4LG4-A nrPDB Length = 299 Score = 43.1 bits (100), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 37/139 (26%), Positives = 71/139 (51%), Gaps = 9/139 (6%) Query: 370 KIADTSEGGIYLGFYEK--QEVAVKTFCEGSPRAQ--REVSCLQSSRENSHLVTFYGSES 425 K+ + S G ++ +++ Q VA+K S + +E+S +Q ++ ++V +YGS Sbjct: 18 KLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQC-DSPYVVKYYGSYF 76 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 L++ + C + D+ R + EDE A +L S K ++ LH H++ Sbjct: 77 KNTDLWIVMEYCGAG--SVSDIIRLRNKTLIEDEIA-TILKSTLKGLEYLHF-MRKIHRN 132 Query: 486 LQPQNILIDSKKAAHLADF 504 ++ NIL++++ A LADF Sbjct: 133 IKAGNILLNTEGHAKLADF 151 >4EQM-A nrPDB Length = 294 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 47/163 (28%), Positives = 72/163 (44%), Gaps = 26/163 (15%) Query: 357 MIGKLKFFIDEKYKIADTSEGGIYLGFYEKQE------VAVKTFC-------EGSPRAQR 403 MIGK+ I+E+YKI D GG Y ++ VA+K E R +R Sbjct: 4 MIGKI---INERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFER 60 Query: 404 EV-SCLQSSRENSHLVTFYGSESHRGHLFVCVTLCE-QTLEACLDVHRGEDVENEEDEFA 461 EV + Q S +N +V+ + ++ + E TL ++ H V+ A Sbjct: 61 EVHNSSQLSHQN--IVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDT-----A 113 Query: 462 RNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 N + I ++ H H+D++PQNILIDS K + DF Sbjct: 114 INFTNQILDGIKHAH-DMRIVHRDIKPQNILIDSNKTLKIFDF 155 >2VN9-A nrPDB Length = 301 Score = 42.7 bits (99), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 47/164 (28%), Positives = 74/164 (45%), Gaps = 42/164 (25%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKK---AAHLADFDKSIKWAGDPQ-- 515 A + + I ++V HL+ G H+DL+P+N+L+ SK A LADF +I+ GD Q Sbjct: 105 ASHCIQQILESVNHCHLN-GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAW 163 Query: 516 ------------EVKR--------DLEDLGRLVLYVVKKGSISFED---------LKAQS 546 EV R D+ G ++LY++ G F D +KA + Sbjct: 164 FGFAGTPGYLSPEVLRKDPYGKPVDMWACG-VILYILLVGYPPFWDEDQHRLYQQIKAGA 222 Query: 547 ----NEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + E ++P E KDLI+++ R S+ L HP+ Sbjct: 223 YDFPSPEWDTVTP--EAKDLINKMLTINPAKRITASEALKHPWI 264 >4CZT-A nrPDB Length = 464 Score = 42.4 bits (98), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 43/163 (26%), Positives = 67/163 (41%), Gaps = 35/163 (21%) Query: 456 EEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI------- 508 +EDE AR + AV H S G H+DL+P+N+L+D+ A ++DF S Sbjct: 109 KEDE-ARKYFQQLINAVDYCH-SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRE 166 Query: 509 -----KWAGDPQEV-------------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEV 550 G P V K DL G ++L+V+ G + FED S + Sbjct: 167 DGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCG-VILFVLMAGYLPFEDSNLTSLYKK 225 Query: 551 V-----QLSP--DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + P K LI R+ P R ++++ + +F Sbjct: 226 IFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWF 268 >2Y7J-A nrPDB Length = 365 Score = 42.0 bits (97), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 30/104 (28%), Positives = 50/104 (48%), Gaps = 5/104 (4%) Query: 401 AQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEF 460 +RE L+ + H++T S +F+ L + L + E V E E Sbjct: 146 TRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRK---GELFDYLTEKVALSEKE- 201 Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 R+++ S+ +AV LH + H+DL+P+NIL+D L+DF Sbjct: 202 TRSIMRSLLEAVSFLH-ANNIVHRDLKPENILLDDNMQIRLSDF 244 >5UIL-A nrPDB Length = 405 Score = 42.0 bits (97), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 31/94 (32%), Positives = 50/94 (53%), Gaps = 8/94 (8%) Query: 66 AVQMSREDIVELLLRHGADPVLRKKN--GATPFILAAIAGSVKLLKLFLSKGADVNECDF 123 A + S + L+R A +L +KN G +P I+AA G+++L+K +SKGA++N+ ++ Sbjct: 285 ACKYSDSKYIAKLIR--AKSILFEKNIYGWSPVIVAAYHGNIELIKWLVSKGANINDRNY 342 Query: 124 YGFTAFMEAAVY----GKVKALKFLYKRGANVNL 153 G T M Y G LK L G ++ L Sbjct: 343 KGTTVAMYFKDYMLKSGDYSGLKMLIDLGLDLTL 376 Score = 35.0 bits (79), Expect = 0.12, Method: Compositional matrix adjust. Identities = 33/119 (27%), Positives = 55/119 (46%), Gaps = 14/119 (11%) Query: 84 DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKF 143 D VL K N + S + KL +K + E + YG++ + AA +G ++ +K+ Sbjct: 271 DVVLYKDNFKEILEACKYSDSKYIAKLIRAKSI-LFEKNIYGWSPVIVAAYHGNIELIKW 329 Query: 144 LYKRGANVNLRRKTKEDQERLRKGGATALM---DAAEKGHVEVLKILLDEMGADVNACD 199 L +GAN+N +R KG A+ + G LK+L+D +G D+ D Sbjct: 330 LVSKGANIN---------DRNYKGTTVAMYFKDYMLKSGDYSGLKMLID-LGLDLTLTD 378 >6EMK-G nrPDB Length = 426 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 46/178 (25%), Positives = 78/178 (43%), Gaps = 18/178 (10%) Query: 99 AAIAGSVKLLKLFLSKGADV--NECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRK 156 A I G++ ++K L + D+ N G+++ A+ +G+ +L + G Sbjct: 12 AIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLG-------- 63 Query: 157 TKEDQERLRKG--GATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSD 214 D+ L K G T + A KGH + L +LL + +N GR A IH +D Sbjct: 64 --HDKHELIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGR-APIHIACMND 120 Query: 215 DSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSD 272 LL+ GAD+ V G TPL + +E + ++ LL + + ++D D Sbjct: 121 ---YYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVSLDDNVRD 175 Score = 37.7 bits (86), Expect = 0.016, Method: Compositional matrix adjust. Identities = 38/166 (22%), Positives = 57/166 (34%), Gaps = 46/166 (27%) Query: 19 RRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELL 78 R A +E N L++K + + DL+ + + E GW+ LH A R I L Sbjct: 10 REAIIEGNLLIVKRLLRRNPDLLTNI----------DSENGWSSLHYASYHGRYLICVYL 59 Query: 79 LRHGAD---------------------------------PVL---RKKNGATPFILAAIA 102 ++ G D P R +NG P +A + Sbjct: 60 IQLGHDKHELIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMN 119 Query: 103 GSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG 148 + L L + GAD+ D G T YG + +K L G Sbjct: 120 DYYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEG 165 >5DND-A nrPDB Length = 588 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 27/76 (35%), Positives = 42/76 (55%), Gaps = 5/76 (6%) Query: 176 AEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVR 235 A G +E L+ L+ E+G+D+ D+ G+ L A + D + +LL G DVN R Sbjct: 430 AHAGELEALQALM-ELGSDLRLKDSNGQTLLHVAARNGRD----GVVTMLLHRGMDVNAR 484 Query: 236 GERGKTPLILAVEKKH 251 G +PL+LAV+ +H Sbjct: 485 DRDGLSPLLLAVQGRH 500 Score = 39.7 bits (91), Expect = 0.005, Method: Compositional matrix adjust. Identities = 31/96 (32%), Positives = 53/96 (55%), Gaps = 2/96 (2%) Query: 209 ALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEIND 268 AL + ++EA+ L++ G+D+ ++ G+T L +A G+V LL + +++N Sbjct: 426 ALALAHAGELEAL-QALMELGSDLRLKDSNGQTLLHVAARNGRDGVVTMLLHR-GMDVNA 483 Query: 269 TDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDL 304 D DG + LLLAV+ + ++ LL K GA DL Sbjct: 484 RDRDGLSPLLLAVQGRHRECIRLLRKAGACLSPQDL 519 Score = 34.3 bits (77), Expect = 0.20, Method: Compositional matrix adjust. Identities = 37/137 (27%), Positives = 63/137 (45%), Gaps = 10/137 (7%) Query: 73 DIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEA 132 + ++ L+ G+D L+ NG T +AA G ++ + L +G DVN D G + + A Sbjct: 436 EALQALMELGSDLRLKDSNGQTLLHVAARNGRDGVVTMLLHRGMDVNARDRDGLSPLLLA 495 Query: 133 AVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMG 192 + ++ L K GA ++ + L+ G T L A + +E L+ + G Sbjct: 496 VQGRHRECIRLLRKAGACLS--------PQDLKDAG-TELCRLASRADMEGLQA-WGQAG 545 Query: 193 ADVNACDNMGRNALIHA 209 AD+ GR+AL A Sbjct: 546 ADLQQPGYDGRSALCVA 562 Score = 29.6 bits (65), Expect = 5.0, Method: Compositional matrix adjust. Identities = 23/86 (26%), Positives = 39/86 (45%), Gaps = 10/86 (11%) Query: 102 AGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQ 161 AG ++ L+ + G+D+ D G T AA G+ + L RG +VN R + Sbjct: 432 AGELEALQALMELGSDLRLKDSNGQTLLHVAARNGRDGVVTMLLHRGMDVNARDRD---- 487 Query: 162 ERLRKGGATALMDAAEKGHVEVLKIL 187 G + L+ A + H E +++L Sbjct: 488 ------GLSPLLLAVQGRHRECIRLL 507 >1BLX-B nrPDB Length = 166 Score = 41.6 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 27/85 (31%), Positives = 46/85 (54%), Gaps = 2/85 (2%) Query: 43 QLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIA 102 +LL+ GA+ N Q+ G +P+H+A + D +++L+ HGAD G+ P LA Sbjct: 59 ELLKQGASPNVQDASGT-SPVHDAARTGFLDTLKVLVEHGADVNALDSTGSLPIHLAIRE 117 Query: 103 GSVKLLKLFLSKGADVNECDFYGFT 127 G ++ FL+ +D++ D G T Sbjct: 118 GHSSVVS-FLAPESDLHHRDASGLT 141 Score = 39.3 bits (90), Expect = 0.006, Method: Composition-based stats. Identities = 32/106 (30%), Positives = 46/106 (43%), Gaps = 1/106 (0%) Query: 78 LLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGK 137 LL+ GA P ++ +G +P AA G + LK+ + GADVN D G A G Sbjct: 60 LLKQGASPNVQDASGTSPVHDAARTGFLDTLKVLVEHGADVNALDSTGSLPIHLAIREGH 119 Query: 138 VKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEV 183 + FL + E R+ GA LMD + GH+ + Sbjct: 120 SSVVSFLAPESDLHHRDASGLTPLELARQRGAQNLMDILQ-GHMMI 164 Score = 35.8 bits (81), Expect = 0.065, Method: Composition-based stats. Identities = 21/69 (30%), Positives = 38/69 (55%), Gaps = 2/69 (2%) Query: 224 LLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVEL 283 +L++HGADVN G P+ LA+ + H +V L + +++ D+ G T L LA + Sbjct: 92 VLVEHGADVNALDSTGSLPIHLAIREGHSSVVSFLAPES--DLHHRDASGLTPLELARQR 149 Query: 284 KLKKIAELL 292 + + ++L Sbjct: 150 GAQNLMDIL 158 Score = 30.8 bits (68), Expect = 2.2, Method: Composition-based stats. Identities = 36/135 (26%), Positives = 55/135 (40%), Gaps = 13/135 (9%) Query: 72 EDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFME 131 +++ LL R P + G T + L+L L +GA N D G + + Sbjct: 22 QEVRRLLHRELVHPDALNRFGKTALQVMMFGSPAVALEL-LKQGASPNVQDASGTSPVHD 80 Query: 132 AAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEM 191 AA G + LK L + GA+VN T G+ + A +GH V+ L E Sbjct: 81 AARTGFLDTLKVLVEHGADVNALDST----------GSLPIHLAIREGHSSVVSFLAPE- 129 Query: 192 GADVNACDNMGRNAL 206 +D++ D G L Sbjct: 130 -SDLHHRDASGLTPL 143 >5Z33-A nrPDB Length = 425 Score = 41.2 bits (95), Expect = 0.002, Method: Compositional matrix adjust. Identities = 39/168 (23%), Positives = 73/168 (43%), Gaps = 18/168 (10%) Query: 363 FFIDEKYKIADTSEGGIY------LGFYEKQEVAVKTFCEG------SPRAQREVSCLQS 410 F +DE+Y + G Y + + VA+K + RA RE+ LQ Sbjct: 27 FIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQH 86 Query: 411 SRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLD--VHRGEDVENEEDEFARNVLSSI 468 R + ++ Y + R F L E+ +E L + G+ + D ++ + I Sbjct: 87 FRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLT---DAHFQSFIYQI 143 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE 516 ++ +H S H+DL+P N+L+++ + DF + ++ DP+E Sbjct: 144 LCGLKYIH-SANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEE 190 >4JXF-A nrPDB Length = 266 Score = 41.2 bits (95), Expect = 0.002, Method: Compositional matrix adjust. Identities = 57/262 (21%), Positives = 100/262 (38%), Gaps = 48/262 (18%) Query: 367 EKYKIADTSEGGIYLGFYEKQ------EVAVKTFCEGS-------PRAQREVSCLQSSRE 413 E +K+ + G + G Y + EVA+K + + R Q EV + + Sbjct: 7 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVK-IHCQLK 65 Query: 414 NSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQ 473 + ++ Y ++++ + +C ++ + V+ + AR+ + I + Sbjct: 66 HPSILELYNYFEDSNYVYLVLEMCHN---GEMNRYLKNRVKPFSENEARHFMHQIITGML 122 Query: 474 ELHLSCGYTHQDLQPQNILIDSKKAAHLADF----------DKSIKWAGDPQEV------ 517 LH S G H+DL N+L+ +ADF +K G P + Sbjct: 123 YLH-SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIAT 181 Query: 518 ------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDE-------ETKDLIH 564 + D+ LG + Y + G F+ ++ V L+ E E KDLIH Sbjct: 182 RSAHGLESDVWSLG-CMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIH 240 Query: 565 RLFHPGEHVRDCLSDLLGHPFF 586 +L R LS +L HPF Sbjct: 241 QLLRRNPADRLSLSSVLDHPFM 262 >3EHQ-A nrPDB Length = 222 Score = 41.2 bits (95), Expect = 0.002, Method: Compositional matrix adjust. Identities = 27/75 (36%), Positives = 36/75 (48%) Query: 226 LDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKL 285 LD+ VN + G T L A H +V+ L Q +IE+N + G TAL A Sbjct: 93 LDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGY 152 Query: 286 KKIAELLCKRGASTD 300 I +LL +GA TD Sbjct: 153 ADIVQLLLAKGARTD 167 Score = 35.8 bits (81), Expect = 0.072, Method: Compositional matrix adjust. Identities = 33/117 (28%), Positives = 52/117 (44%), Gaps = 12/117 (10%) Query: 164 LRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITH 223 L K G+TAL A GH +++++L + ++N + +G AL HA +D I Sbjct: 102 LDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNKLGDTAL-HAAAWKGYAD---IVQ 157 Query: 224 LLLDHGADVNVRGERGKTPLILAVEKKHLGLVQ--------RLLEQEHIEINDTDSD 272 LLL GA ++R K +A L++ R L ++D DSD Sbjct: 158 LLLAKGARTDLRNIEKKLAFDMATNAACASLLKKKQGTDAVRTLSNAEDYLDDEDSD 214 Score = 32.3 bits (72), Expect = 0.70, Method: Compositional matrix adjust. Identities = 22/56 (39%), Positives = 26/56 (46%) Query: 54 QEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLK 109 Q+ + G T LH A DIV+LLL GA LR F +A A LLK Sbjct: 135 QQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLLK 190 >1V0B-A nrPDB Length = 288 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 41/149 (27%), Positives = 64/149 (42%), Gaps = 17/149 (11%) Query: 367 EKYKIADTSEGGIYLGFYEKQEVAVKTFC----------EGSPRAQ-REVSCLQSSRENS 415 EKY + G Y Y+ Q +TF EG P RE+S L+ + +S Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELK-HS 60 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 ++V Y + L + +Q L+ LDV G E A++ L + + Sbjct: 61 NIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEG----GLESVTAKSFLLQLLNGIAYC 116 Query: 476 HLSCGYTHQDLQPQNILIDSKKAAHLADF 504 H H+DL+PQN+LI+ + +ADF Sbjct: 117 H-DRRVLHRDLKPQNLLINREGELKIADF 144 >6DMR-A nrPDB Length = 730 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 49/194 (25%), Positives = 90/194 (46%), Gaps = 17/194 (8%) Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNE----CD-FYGFTAFMEAAVYGKVKALK 142 R G T +AA+ +++ L + ++ + C+ F G TA A + + ++ Sbjct: 75 RGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVR 134 Query: 143 FLYKRGANVNLRRK---TKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACD 199 L RGA+V+ R + L G L AA G E++++L+ E GAD+ A D Sbjct: 135 ALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLI-EHGADIRAQD 193 Query: 200 NMGRNALIHALLSSDDSDVEAITHLLL------DHGADVN-VRGERGKTPLILAVEKKHL 252 ++G L +L + + + +LLL DH + V +G TP LA + + Sbjct: 194 SLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNT 253 Query: 253 GLVQRLLEQ-EHIE 265 + Q L+++ +H++ Sbjct: 254 VMFQHLMQKRKHVQ 267 Score = 35.0 bits (79), Expect = 0.11, Method: Compositional matrix adjust. Identities = 22/65 (33%), Positives = 34/65 (52%), Gaps = 12/65 (18%) Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWT------------PLHNAVQMSREDIVELLL 79 AV N++++LV+ LL GA+V+ + + PL A + E+IV LL+ Sbjct: 124 AVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLI 183 Query: 80 RHGAD 84 HGAD Sbjct: 184 EHGAD 188 Score = 28.9 bits (63), Expect = 8.2, Method: Compositional matrix adjust. Identities = 39/137 (28%), Positives = 56/137 (40%), Gaps = 20/137 (14%) Query: 121 CDF-----YGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDA 175 CDF G TA AA+Y ++A L + + KE G TAL A Sbjct: 70 CDFQQRGAVGETALHVAALYDNLEAATLLMEAAPEL-----AKEPALCEPFVGQTALHIA 124 Query: 176 AEKGHVEVLKILLDEMGADVNA-----CDNMGRNALI----HALLSSDDSDVEAITHLLL 226 ++ +++ LL GA V+A + LI H L + E I LL+ Sbjct: 125 VMNQNLNLVRALLAR-GASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLI 183 Query: 227 DHGADVNVRGERGKTPL 243 +HGAD+ + G T L Sbjct: 184 EHGADIRAQDSLGNTVL 200 >3TKU-A nrPDB Length = 433 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 88/215 (40%), Gaps = 53/215 (24%) Query: 458 DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKW------- 510 ++ AR + + A+ +H Y H+D++P N+L+D LADF +K Sbjct: 190 EDMARFYIGEMVLAIDSIH-QLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQ 248 Query: 511 ----AGDPQ----EVKRDLED-LGR-----------LVLYVVKKGSISF--EDL-----K 543 G P E+ + +ED +G+ + +Y + G F E L K Sbjct: 249 SSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGK 308 Query: 544 AQSNEEVVQLSP-----DEETKDLIHRLFHPGEHV--RDCLSDLLGHPFF--WTWESRYR 594 ++EE Q EE KDLI RL E ++ + D H FF WE+ R Sbjct: 309 IMNHEERFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWEN-IR 367 Query: 595 TLR-----NVGNESDIKTRKSESEILR---LLQPG 621 L +V + SD + ++LR +L PG Sbjct: 368 NLEAPYIPDVSSPSDTSNFDVDDDVLRNTEILPPG 402 >4AU8-A nrPDB Length = 296 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 29/109 (26%), Positives = 48/109 (44%), Gaps = 5/109 (4%) Query: 396 EGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVEN 455 EG P + CL ++ ++V + L + C+Q L+ D G+ Sbjct: 46 EGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD---- 101 Query: 456 EEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 + E ++ L + K + H S H+DL+PQN+LI+ LADF Sbjct: 102 LDPEIVKSFLFQLLKGLGFCH-SRNVLHRDLKPQNLLINRNGELKLADF 149 >1D9S-A nrPDB Length = 136 Score = 39.7 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 35/103 (33%), Positives = 47/103 (45%), Gaps = 13/103 (12%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 L A V+ V+QLLE GA+ N G P+ + M + ELLL HGA+P Sbjct: 16 LATAAARGQVETVRQLLEAGADPN-ALNRFGRRPIQ-VMMMGSAQVAELLLLHGAEP--- 70 Query: 89 KKNGATPFIL------AAIAGSVKLLKLFLSKGADVNECDFYG 125 N A P L AA G + L + GA ++ CD +G Sbjct: 71 --NCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVCDAWG 111 Score = 36.6 bits (83), Expect = 0.045, Method: Composition-based stats. Identities = 26/69 (37%), Positives = 37/69 (53%), Gaps = 8/69 (11%) Query: 167 GGAT--ALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHL 224 GG++ L AA +G VE ++ LL E GAD NA + GR + ++ S + L Sbjct: 9 GGSSDAGLATAAARGQVETVRQLL-EAGADPNALNRFGRRPIQVMMMGS-----AQVAEL 62 Query: 225 LLDHGADVN 233 LL HGA+ N Sbjct: 63 LLLHGAEPN 71 >5U6Y-A nrPDB Length = 461 Score = 39.3 bits (90), Expect = 0.006, Method: Compositional matrix adjust. Identities = 45/164 (27%), Positives = 70/164 (42%), Gaps = 42/164 (25%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK---KAAHLADFDKSIK-------W 510 A + + I +AV H G H+DL+P+N+L+ SK A LADF +I+ W Sbjct: 101 ASHCIQQILEAVLHCH-QMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAW 159 Query: 511 AG---------------DPQEVKRDLEDLGRLVLYVVKKGSISFED---------LKAQS 546 G DP DL G ++LY++ G F D +KA + Sbjct: 160 FGFAGTPGYLSPEVLRKDPYGKPVDLWACG-VILYILLVGYPPFWDEDQHRLYQQIKAGA 218 Query: 547 ----NEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + E ++P E KDLI+++ R ++ L HP+ Sbjct: 219 YDFPSPEWDTVTP--EAKDLINKMLTINPSKRITAAEALKHPWI 260 >1G3N-A nrPDB Length = 326 Score = 39.3 bits (90), Expect = 0.006, Method: Compositional matrix adjust. Identities = 44/149 (29%), Positives = 66/149 (44%), Gaps = 25/149 (16%) Query: 369 YKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQ-REVSCLQSSRENSHLVTFYGSESHR 427 +K D GG ++ + V V+T EG P + REV+ L+ HL TF R Sbjct: 28 FKARDLKNGGRFVAL---KRVRVQTGEEGMPLSTIREVAVLR------HLETFEHPNVVR 78 Query: 428 GHLFVCVTLCEQTLEACLDV---HRGEDVENEED---------EFARNVLSSIFKAVQEL 475 LF T+ E L + H +D+ D E ++++ + + + L Sbjct: 79 --LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 Query: 476 HLSCGYTHQDLQPQNILIDSKKAAHLADF 504 H S H+DL+PQNIL+ S LADF Sbjct: 137 H-SHRVVHRDLKPQNILVTSSGQIKLADF 164 >4AW2-A nrPDB Length = 437 Score = 39.3 bits (90), Expect = 0.006, Method: Compositional matrix adjust. Identities = 46/171 (26%), Positives = 66/171 (38%), Gaps = 44/171 (25%) Query: 458 DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKW------- 510 +E AR L+ + A+ +H Y H+D++P NIL+D LADF +K Sbjct: 174 EEMARFYLAEMVIAIDSVH-QLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQ 232 Query: 511 ----AGDPQEVKR-----------------DLEDLGRLVLYVVKKGSISF--EDL----- 542 G P + D LG + +Y + G F E L Sbjct: 233 SSVAVGTPDYISPEILQAMEGGKGRYGPECDWWSLG-VCMYEMLYGETPFYAESLVETYG 291 Query: 543 KAQSNEEVVQLSP-----DEETKDLIHRLFHPGEHV--RDCLSDLLGHPFF 586 K +++E Q E KDLI RL EH ++ + D HPFF Sbjct: 292 KIMNHKERFQFPTQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFF 342 >2RFA-A nrPDB Length = 232 Score = 39.3 bits (90), Expect = 0.006, Method: Compositional matrix adjust. Identities = 48/160 (30%), Positives = 72/160 (45%), Gaps = 16/160 (10%) Query: 94 TPFILAAIAGSVKLL-KLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVN 152 +P +LAA V+ L KL +G +V++ G TA AA+Y ++A L + + Sbjct: 5 SPLLLAAKENDVQALSKLLKFEGCEVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELV 64 Query: 153 LRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNA-----CDNMGRNALI 207 T E E G TAL A +V +++ LL GA V+A + + LI Sbjct: 65 FEPMTSELYE-----GQTALHIAVINQNVNLVRALLAR-GASVSARATGSVFHYRPHNLI 118 Query: 208 ----HALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPL 243 H L + E I LL++HGAD+ + G T L Sbjct: 119 YYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVL 158 Score = 38.1 bits (87), Expect = 0.013, Method: Compositional matrix adjust. Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 10/148 (6%) Query: 123 FYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQER---LRKGGATALMDAAEKG 179 + G TA A + V ++ L RGA+V+ R R L G L AA G Sbjct: 73 YEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVG 132 Query: 180 HVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLL-----DHGADVN- 233 E++++L+ E GAD+ A D++G L +L + + + +LLL DH + Sbjct: 133 SEEIVRLLI-EHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGGDHLKSLEL 191 Query: 234 VRGERGKTPLILAVEKKHLGLVQRLLEQ 261 V +G TP LA + ++ + Q L+++ Sbjct: 192 VPNNQGLTPFKLAGVEGNIVMFQHLMQK 219 Score = 36.2 bits (82), Expect = 0.047, Method: Compositional matrix adjust. Identities = 29/96 (30%), Positives = 50/96 (52%), Gaps = 4/96 (4%) Query: 210 LLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDT 269 LL++ ++DV+A++ LL G +V+ RG G+T L +A +L L+E + + Sbjct: 8 LLAAKENDVQALSKLLKFEGCEVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEP 67 Query: 270 DS----DGKTALLLAVELKLKKIAELLCKRGASTDC 301 + +G+TAL +AV + + L RGAS Sbjct: 68 MTSELYEGQTALHIAVINQNVNLVRALLARGASVSA 103 Score = 35.0 bits (79), Expect = 0.13, Method: Compositional matrix adjust. Identities = 24/65 (36%), Positives = 34/65 (52%), Gaps = 12/65 (18%) Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEG------------GWTPLHNAVQMSREDIVELLL 79 AV N++V+LV+ LL GA+V+ + G PL A + E+IV LL+ Sbjct: 82 AVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGSEEIVRLLI 141 Query: 80 RHGAD 84 HGAD Sbjct: 142 EHGAD 146 >3UI2-A nrPDB Length = 244 Score = 39.3 bits (90), Expect = 0.006, Method: Compositional matrix adjust. Identities = 31/109 (28%), Positives = 49/109 (44%), Gaps = 23/109 (21%) Query: 11 EGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQ--------------------LLEGGAN 50 E P ++ R+A D L + +++ DVD V + L E GA+ Sbjct: 46 ETPWWTAARKA---DEQALSQLLEDRDVDAVDENGRTALLFVAGLGSDKCVRLLAEAGAD 102 Query: 51 VNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILA 99 ++ ++ GG T LH A R ++VE L+ GAD + + G T LA Sbjct: 103 LDHRDMRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELA 151 Score = 36.6 bits (83), Expect = 0.044, Method: Compositional matrix adjust. Identities = 29/95 (30%), Positives = 46/95 (48%), Gaps = 4/95 (4%) Query: 61 TPLHNAVQMSREDIVELLLR-HGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVN 119 TP A + + E + LL D V +NG T + A GS K ++L GAD++ Sbjct: 47 TPWWTAARKADEQALSQLLEDRDVDAV--DENGRTALLFVAGLGSDKCVRLLAEAGADLD 104 Query: 120 ECDFY-GFTAFMEAAVYGKVKALKFLYKRGANVNL 153 D G TA AA Y + + ++ L + GA++ + Sbjct: 105 HRDMRGGLTALHMAAGYVRPEVVEALVELGADIEV 139 Score = 32.0 bits (71), Expect = 1.1, Method: Compositional matrix adjust. Identities = 30/89 (33%), Positives = 44/89 (49%), Gaps = 4/89 (4%) Query: 160 DQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVE 219 D + + + G TAL+ A G + ++ LL E GAD++ D G +H +V Sbjct: 69 DVDAVDENGRTALLFVAGLGSDKCVR-LLAEAGADLDHRDMRGGLTALHMAAGYVRPEV- 126 Query: 220 AITHLLLDHGADVNVRGERGKTPLILAVE 248 L++ GAD+ V ERG T L LA E Sbjct: 127 --VEALVELGADIEVEDERGLTALELARE 153 Score = 31.2 bits (69), Expect = 1.9, Method: Compositional matrix adjust. Identities = 21/65 (32%), Positives = 31/65 (47%), Gaps = 2/65 (3%) Query: 240 KTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAST 299 +TP A K + +LLE +++ D +G+TALL L K LL + GA Sbjct: 46 ETPWWTAARKADEQALSQLLEDR--DVDAVDENGRTALLFVAGLGSDKCVRLLAEAGADL 103 Query: 300 DCGDL 304 D D+ Sbjct: 104 DHRDM 108 >2VZ6-A nrPDB Length = 313 Score = 39.3 bits (90), Expect = 0.007, Method: Compositional matrix adjust. Identities = 45/164 (27%), Positives = 70/164 (42%), Gaps = 42/164 (25%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK---KAAHLADFDKSIK-------W 510 A + + I +AV H G H+DL+P+N+L+ SK A LADF +I+ W Sbjct: 123 ASHCIQQILEAVLHCH-QMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAW 181 Query: 511 AG---------------DPQEVKRDLEDLGRLVLYVVKKGSISFED---------LKAQS 546 G DP DL G ++LY++ G F D +KA + Sbjct: 182 FGFAGTPGYLSPEVLRKDPYGKPVDLWACG-VILYILLVGYPPFWDEDQHRLYQQIKAGA 240 Query: 547 ----NEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + E ++P E KDLI+++ R ++ L HP+ Sbjct: 241 YDFPSPEWDTVTP--EAKDLINKMLTINPSKRITAAEALKHPWI 282 >4NIF-A nrPDB Length = 333 Score = 38.9 bits (89), Expect = 0.008, Method: Compositional matrix adjust. Identities = 42/165 (25%), Positives = 70/165 (42%), Gaps = 42/165 (25%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNIL-ID---SKKAAHLADFDKSIKWAGD--- 513 A VL +I K V+ LH S G H+DL+P NIL +D + + + DF + + + Sbjct: 104 ASFVLHTIGKTVEYLH-SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGL 162 Query: 514 ------------PQEVKR-------DLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQL- 553 P+ +KR D+ LG ++LY + G F + + + EE++ Sbjct: 163 LMTPCYTANFVAPEVLKRQGYDEGCDIWSLG-ILLYTMLAGYTPFANGPSDTPEEILTRI 221 Query: 554 -------------SPDEETKDLIHRLFHPGEHVRDCLSDLLGHPF 585 + E KDL+ ++ H H R +L HP+ Sbjct: 222 GSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPW 266 >3DEO-A nrPDB Length = 183 Score = 38.9 bits (89), Expect = 0.009, Method: Compositional matrix adjust. Identities = 31/109 (28%), Positives = 49/109 (44%), Gaps = 23/109 (21%) Query: 11 EGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQ--------------------LLEGGAN 50 E P ++ R+A D L + +++ DVD V + L E GA+ Sbjct: 45 ETPWWTAARKA---DEQALSQLLEDRDVDAVDENGRTALLFVAGLGSDKCVRLLAEAGAD 101 Query: 51 VNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILA 99 ++ ++ GG T LH A R ++VE L+ GAD + + G T LA Sbjct: 102 LDHRDMRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELA 150 Score = 36.2 bits (82), Expect = 0.060, Method: Compositional matrix adjust. Identities = 29/95 (30%), Positives = 46/95 (48%), Gaps = 4/95 (4%) Query: 61 TPLHNAVQMSREDIVELLLR-HGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVN 119 TP A + + E + LL D V +NG T + A GS K ++L GAD++ Sbjct: 46 TPWWTAARKADEQALSQLLEDRDVDAV--DENGRTALLFVAGLGSDKCVRLLAEAGADLD 103 Query: 120 ECDFY-GFTAFMEAAVYGKVKALKFLYKRGANVNL 153 D G TA AA Y + + ++ L + GA++ + Sbjct: 104 HRDMRGGLTALHMAAGYVRPEVVEALVELGADIEV 138 Score = 32.0 bits (71), Expect = 1.1, Method: Compositional matrix adjust. Identities = 30/89 (33%), Positives = 44/89 (49%), Gaps = 4/89 (4%) Query: 160 DQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVE 219 D + + + G TAL+ A G + ++ LL E GAD++ D G +H +V Sbjct: 68 DVDAVDENGRTALLFVAGLGSDKCVR-LLAEAGADLDHRDMRGGLTALHMAAGYVRPEV- 125 Query: 220 AITHLLLDHGADVNVRGERGKTPLILAVE 248 L++ GAD+ V ERG T L LA E Sbjct: 126 --VEALVELGADIEVEDERGLTALELARE 152 Score = 30.8 bits (68), Expect = 2.4, Method: Compositional matrix adjust. Identities = 21/65 (32%), Positives = 31/65 (47%), Gaps = 2/65 (3%) Query: 240 KTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAST 299 +TP A K + +LLE +++ D +G+TALL L K LL + GA Sbjct: 45 ETPWWTAARKADEQALSQLLEDR--DVDAVDENGRTALLFVAGLGSDKCVRLLAEAGADL 102 Query: 300 DCGDL 304 D D+ Sbjct: 103 DHRDM 107 >3UIU-A nrPDB Length = 306 Score = 38.5 bits (88), Expect = 0.010, Method: Compositional matrix adjust. Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 5/84 (5%) Query: 422 GSESHRGHLFVCVTLCEQ-TLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG 480 S S LF+ + C++ TLE ++ RGE ++ A + I K V +H S Sbjct: 101 SSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKV---LALELFEQITKGVDYIH-SKK 156 Query: 481 YTHQDLQPQNILIDSKKAAHLADF 504 H+DL+P NI + K + DF Sbjct: 157 LIHRDLKPSNIFLVDTKQVKIGDF 180 >6FDY-U nrPDB Length = 276 Score = 38.5 bits (88), Expect = 0.012, Method: Compositional matrix adjust. Identities = 46/161 (28%), Positives = 69/161 (42%), Gaps = 35/161 (21%) Query: 458 DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAH--LADF---------DK 506 ++ AR + + A+Q LH +H DL+PQNIL+ S + H LADF D+ Sbjct: 110 EKVARVFMQQLASALQFLH-ERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDE 168 Query: 507 SIKWAGDP------------QEVKRDLEDLGRLVLYVVKKG-----SISFEDL--KAQSN 547 G P + + DL +G ++LY G S SF +L K +SN Sbjct: 169 KHVLRGSPLYMAPEMVCQRQYDARVDLWSMG-VILYEALFGQPPFASRSFSELEEKIRSN 227 Query: 548 EEV-VQLSP--DEETKDLIHRLFHPGEHVRDCLSDLLGHPF 585 + + L P + +DL+ RL R D HP+ Sbjct: 228 RVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPW 268 >2XNP-A nrPDB Length = 279 Score = 38.5 bits (88), Expect = 0.012, Method: Compositional matrix adjust. Identities = 31/111 (27%), Positives = 55/111 (49%), Gaps = 8/111 (7%) Query: 402 QREVSCLQSSRENSH--LVTFYGSESHRGH--LFVCVTLCEQTLEACLDVHRGEDVENEE 457 Q VS + RE H +V +Y R + L++ + CE A + ++ + + Sbjct: 50 QMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLD 109 Query: 458 DEFARNVLSSIFKAVQELHLSC--GYT--HQDLQPQNILIDSKKAAHLADF 504 +EF V++ + A++E H G+T H+DL+P N+ +D K+ L DF Sbjct: 110 EEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDF 160 >3NIZ-A nrPDB Length = 311 Score = 38.1 bits (87), Expect = 0.015, Method: Compositional matrix adjust. Identities = 34/110 (30%), Positives = 50/110 (45%), Gaps = 7/110 (6%) Query: 396 EGSPR-AQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVE 454 EG P A RE+S L+ + + S R C+TL + +E L E+ Sbjct: 60 EGIPSTAIREISLLKELHHPNIVSLIDVIHSER-----CLTLVFEFMEKDLKKVLDENKT 114 Query: 455 NEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 +D + L + + V H H+DL+PQN+LI+S A LADF Sbjct: 115 GLQDSQIKIYLYQLLRGVAHCH-QHRILHRDLKPQNLLINSDGALKLADF 163 >4JG6-A nrPDB Length = 355 Score = 38.1 bits (87), Expect = 0.015, Method: Compositional matrix adjust. Identities = 42/170 (24%), Positives = 72/170 (42%), Gaps = 42/170 (24%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNIL-ID---SKKAAHLADFDKSIKWAGD--- 513 A VL +I K V+ LH + G H+DL+P NIL +D + ++ + DF + + + Sbjct: 131 ASAVLFTITKTVEYLH-AQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGL 189 Query: 514 ------------PQEVKR-------DLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQL- 553 P+ ++R D+ LG L LY + G F + + EE++ Sbjct: 190 LMTPCYTANFVAPEVLERQGYDAACDIWSLGVL-LYTMLTGYTPFANGPDDTPEEILARI 248 Query: 554 -------------SPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWE 590 S + KDL+ ++ H H R + +L HP+ W+ Sbjct: 249 GSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWD 298 >3BHH-A nrPDB Length = 295 Score = 38.1 bits (87), Expect = 0.016, Method: Compositional matrix adjust. Identities = 23/58 (39%), Positives = 33/58 (56%), Gaps = 4/58 (6%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK---KAAHLADFDKSIKWAGDPQ 515 A + + I +AV H G H+DL+P+N+L+ SK A LADF +I+ GD Q Sbjct: 105 ASHCIQQILEAVLHCH-QMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQ 161 >3MN3-A nrPDB Length = 271 Score = 37.7 bits (86), Expect = 0.016, Method: Compositional matrix adjust. Identities = 40/152 (26%), Positives = 66/152 (43%), Gaps = 20/152 (13%) Query: 369 YKIADT----SEGGIYLGFYEK--QEVAVKTF-------CEGSPRAQREVSCLQSSRENS 415 Y+I T S G + L ++ Q+VA+K + R +RE+S L+ R + Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLR-HP 64 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 H++ Y + + + + L + V R + E E AR I AV+ Sbjct: 65 HIIKLYDVIKSKDEIIMVIEYAGNELFDYI-VQRDKMSEQE----ARRFFQQIISAVEYC 119 Query: 476 HLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 H H+DL+P+N+L+D +ADF S Sbjct: 120 H-RHKIVHRDLKPENLLLDEHLNVKIADFGLS 150 >3SOA-A nrPDB Length = 444 Score = 37.7 bits (86), Expect = 0.016, Method: Compositional matrix adjust. Identities = 44/164 (26%), Positives = 70/164 (42%), Gaps = 42/164 (25%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK---KAAHLADFDKSIK-------W 510 A + + I +AV H G H++L+P+N+L+ SK A LADF +I+ W Sbjct: 112 ASHCIQQILEAVLHCH-QMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAW 170 Query: 511 AG---------------DPQEVKRDLEDLGRLVLYVVKKGSISFED---------LKAQS 546 G DP DL G ++LY++ G F D +KA + Sbjct: 171 FGFAGTPGYLSPEVLRKDPYGKPVDLWACG-VILYILLVGYPPFWDEDQHRLYQQIKAGA 229 Query: 547 ----NEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + E ++P E KDLI+++ R ++ L HP+ Sbjct: 230 YDFPSPEWDTVTP--EAKDLINKMLTINPSKRITAAEALKHPWI 271 >6CV9-A nrPDB Length = 842 Score = 37.7 bits (86), Expect = 0.018, Method: Compositional matrix adjust. Identities = 29/98 (29%), Positives = 54/98 (55%), Gaps = 5/98 (5%) Query: 229 GADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEH-IEINDTDSDGKTALLLAVELKLKK 287 G+ +++ ER + A E ++ +V+++LE+ H + +N D G+ AL LAV + + Sbjct: 3 GSMLSIEEER----FLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLE 58 Query: 288 IAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGA 325 I ELL K+ + GD ++ A +V+ +L+H A Sbjct: 59 ITELLLKKENLSRVGDALLLAISKGYVRIVEAILNHPA 96 Score = 37.4 bits (85), Expect = 0.027, Method: Compositional matrix adjust. Identities = 42/154 (27%), Positives = 71/154 (46%), Gaps = 34/154 (22%) Query: 172 LMDAAEKGHVEVLKILLDEM-GADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGA 230 +DAAE G++ V++ +L+E +VN D MG+NAL L+ + +E IT LLL Sbjct: 13 FLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNAL---QLAVANEHLE-ITELLLKKE- 67 Query: 231 DVNVRGERGKTPLILAVEKKHLGLVQRLL---------------EQEHIEIND---TDSD 272 R L+LA+ K ++ +V+ +L Q ++ +D D D Sbjct: 68 ----NLSRVGDALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDED 123 Query: 273 GK------TALLLAVELKLKKIAELLCKRGASTD 300 G T ++LA + +I L ++GA + Sbjct: 124 GTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIE 157 >4NFN-A nrPDB Length = 309 Score = 37.7 bits (86), Expect = 0.020, Method: Compositional matrix adjust. Identities = 37/200 (18%), Positives = 84/200 (42%), Gaps = 23/200 (11%) Query: 363 FFIDEKYKIADTSEGGIYLGFYE------KQEVAVKTFCEGSPRA--QREVSCLQSSREN 414 + + +++K+ GG + YE ++ VA+K P+ + EV+ L+ + Sbjct: 17 YVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGK 76 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 H+ F G + +V + L + L D+ R + + I ++++ Sbjct: 77 DHVCRFIGCGRNEKFNYVVMQLQGRNLA---DLRRSQPRGTFTLSTTLRLGKQILESIEA 133 Query: 475 LHLSCGYTHQDLQPQNI----LIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLY 530 +H S G+ H+D++P N L + + ++ DF + ++ +V+ G Sbjct: 134 IH-SVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGF---- 188 Query: 531 VVKKGSISFEDLKAQSNEEV 550 +G++ + + A N E+ Sbjct: 189 ---RGTVRYASVNAHKNREM 205 >2OU7-A nrPDB Length = 335 Score = 37.4 bits (85), Expect = 0.021, Method: Compositional matrix adjust. Identities = 46/218 (21%), Positives = 85/218 (38%), Gaps = 36/218 (16%) Query: 400 RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDE 459 + E+S + S + H+V F+G +FV + LC + + L++H+ E + Sbjct: 87 KMSMEIS-IHRSLAHQHVVGFHGFFEDNDFVFVVLELCRR--RSLLELHKRRKALTEPE- 142 Query: 460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK---------- 509 AR L I Q LH + H+DL+ N+ ++ + DF + K Sbjct: 143 -ARYYLRQIVLGCQYLHRN-RVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKV 200 Query: 510 WAGDPQEV------------KRDLEDLGRLVLYVVKKGSISFED-------LKAQSNEEV 550 G P + + D+ +G ++Y + G FE L+ + NE Sbjct: 201 LCGTPNYIAPEVLSKKGHSFEVDVWSIG-CIMYTLLVGKPPFETSCLKETYLRIKKNEYS 259 Query: 551 VQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWT 588 + + LI ++ R +++LL FF + Sbjct: 260 IPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTS 297 >4J52-A nrPDB Length = 293 Score = 37.4 bits (85), Expect = 0.024, Method: Compositional matrix adjust. Identities = 46/218 (21%), Positives = 85/218 (38%), Gaps = 36/218 (16%) Query: 400 RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDE 459 + E+S + S + H+V F+G +FV + LC + + L++H+ E + Sbjct: 60 KMSMEIS-IHRSLAHQHVVGFHGFFEDNDFVFVVLELCRR--RSLLELHKRRKALTEPE- 115 Query: 460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK---------- 509 AR L I Q LH + H+DL+ N+ ++ + DF + K Sbjct: 116 -ARYYLRQIVLGCQYLHRN-RVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKV 173 Query: 510 WAGDPQEV------------KRDLEDLGRLVLYVVKKGSISFED-------LKAQSNEEV 550 G P + + D+ +G ++Y + G FE L+ + NE Sbjct: 174 LCGTPNYIAPEVLSKKGHSFEVDVWSIG-CIMYTLLVGKPPFETSCLKETYLRIKKNEYS 232 Query: 551 VQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWT 588 + + LI ++ R +++LL FF + Sbjct: 233 IPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTS 270 >6CUD-A nrPDB Length = 806 Score = 37.0 bits (84), Expect = 0.027, Method: Compositional matrix adjust. Identities = 46/178 (25%), Positives = 78/178 (43%), Gaps = 43/178 (24%) Query: 172 LMDAAEKGHVEVLKILLDEMGA-DVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGA 230 +DAAE G++ V++ +L+E +VN D MG+NAL L+ + +E +T LLL Sbjct: 31 FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNAL---QLAVGNEHLE-VTELLLKKE- 85 Query: 231 DVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHI-------------EIND-----TDSD 272 R L+LA+ K ++ +V+ +L E+ D D D Sbjct: 86 ----NLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDED 141 Query: 273 GK------TALLLAVELKLKKIAELLCKRGASTD--------CGDLVMTARRN-YDHS 315 G T ++LA + ++ +L +GA + CGD + R + + HS Sbjct: 142 GTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHS 199 Score = 33.9 bits (76), Expect = 0.28, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 50/98 (51%), Gaps = 5/98 (5%) Query: 227 DHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQ-EHIEINDTDSDGKTALLLAVELKL 285 D G + ER + A E ++ +V+++LE+ + + +N D G+ AL LAV + Sbjct: 19 DRGTSLTAEEER----FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEH 74 Query: 286 KKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSH 323 ++ ELL K+ GD ++ A +V+ +L+H Sbjct: 75 LEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNH 112 >4BTK-A nrPDB Length = 337 Score = 37.0 bits (84), Expect = 0.028, Method: Compositional matrix adjust. Identities = 37/200 (18%), Positives = 84/200 (42%), Gaps = 23/200 (11%) Query: 363 FFIDEKYKIADTSEGGIYLGFYE------KQEVAVKTFCEGSPRA--QREVSCLQSSREN 414 + + +++K+ GG + YE ++ VA+K P+ + EV+ L+ + Sbjct: 52 YVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGK 111 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 H+ F G + +V + L + L D+ R + + I ++++ Sbjct: 112 DHVCRFIGCGRNEKFNYVVMQLQGRNLA---DLRRSQPRGTFTLSTTLRLGKQILESIEA 168 Query: 475 LHLSCGYTHQDLQPQNI----LIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLY 530 +H S G+ H+D++P N L + + ++ DF + ++ +V+ G Sbjct: 169 IH-SVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGF---- 223 Query: 531 VVKKGSISFEDLKAQSNEEV 550 +G++ + + A N E+ Sbjct: 224 ---RGTVRYASVNAHKNREM 240 >5FG8-A nrPDB Length = 285 Score = 37.0 bits (84), Expect = 0.029, Method: Compositional matrix adjust. Identities = 42/164 (25%), Positives = 75/164 (45%), Gaps = 42/164 (25%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK---KAAHLADFDKSIKWAGD---- 513 A + + I ++V H + G H+DL+P+N+L+ SK A LADF +I+ GD Sbjct: 115 ASHCIQQILESVNHCHQN-GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAW 173 Query: 514 -----------PQEVKR-------DLEDLGRLVLYVVKKGSISFED---------LKAQS 546 P+ +K+ D+ G ++LY++ G F D +KA + Sbjct: 174 FGFAGTPGYLSPEVLKKEPYGKSVDIWACG-VILYILLVGYPPFWDEDQHRLYSQIKAGA 232 Query: 547 ----NEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + E ++P E K+LI+++ + R ++ L HP+ Sbjct: 233 YDYPSPEWDTVTP--EAKNLINQMLTVNPNKRITAAEALKHPWI 274 >3LJN-A nrPDB Length = 364 Score = 37.0 bits (84), Expect = 0.032, Method: Compositional matrix adjust. Identities = 63/261 (24%), Positives = 104/261 (39%), Gaps = 46/261 (17%) Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91 A + D V++L+E G + Q G T LH A + D + L G V + Sbjct: 27 AARKGQTDEVRRLIETGVSPTIQNR-FGCTALHLACKFGCVDTAKYLASVGE--VHSLWH 83 Query: 92 GATPFILAAIAGSVKLLKLFLSKGAD---------VNECD-------------FYGFTAF 129 G P LA +A L+ + L +GA +NECD G TA Sbjct: 84 GQKPIHLAVMANKTDLV-VALVEGAKERGQMPESLLNECDEREVNEIGSHVKHCKGQTAL 142 Query: 130 MEAAVYGK--VKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKIL 187 G ++ +K L + GA+ + K E T LM A E + E L ++ Sbjct: 143 HWCVGLGPEYLEMIKILVQLGASPTAKDKADE----------TPLMRAMEFRNREALDLM 192 Query: 188 LDEMGAD----VNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPL 243 +D + + ++ + G + L A+L + E + ++ G DVN+ PL Sbjct: 193 MDTVPSKSSLRLDYANKQGNSHLHWAILI----NWEDVAMRFVEMGIDVNMEDNEHTVPL 248 Query: 244 ILAVEKKHLGLVQRLLEQEHI 264 L+V + L + LL++ + Sbjct: 249 YLSVRAAMVLLTKELLQKTDV 269 >5U0K-A nrPDB Length = 141 Score = 37.0 bits (84), Expect = 0.035, Method: Compositional matrix adjust. Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 9/94 (9%) Query: 96 FILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR 155 + AA +G V L+ F D+ + D+ TA AA G ++ +KFL + VN Sbjct: 29 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIE-ACKVNPFA 87 Query: 156 KTKEDQERLRKGGATALMDAAEKGHVEVLKILLD 189 K + G L DA + H+EV+K+L D Sbjct: 88 KDR--------WGNIPLDDAVQFNHLEVVKLLQD 113 >1AD5-A nrPDB Length = 438 Score = 36.6 bits (83), Expect = 0.037, Method: Compositional matrix adjust. Identities = 25/86 (29%), Positives = 41/86 (47%), Gaps = 18/86 (20%) Query: 481 YTHQDLQPQNILIDSKKAAHLADFDKS-------IKWAGDPQ-------EVKRDLEDLGR 526 Y H+DL+ NIL+ + +ADF + IKW P+ +K D+ G Sbjct: 299 YIHRDLRAANILVSASLVCKIADFGLARVGAKFPIKWTA-PEAINFGSFTIKSDVWSFGI 357 Query: 527 LVLYVVKKGSISFEDLKAQSNEEVVQ 552 L++ +V G I + + SN EV++ Sbjct: 358 LLMEIVTYGRIPYPGM---SNPEVIR 380 >2A1A-B nrPDB Length = 284 Score = 36.6 bits (83), Expect = 0.041, Method: Compositional matrix adjust. Identities = 38/150 (25%), Positives = 64/150 (42%), Gaps = 27/150 (18%) Query: 377 GGIYLGFYEKQEVAVKTFC-----EGSPRAQREVSCLQSSRENSHLVTFYG--------- 422 GG F K + KT+ + +A+REV L + ++ ++V + G Sbjct: 22 GGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKAL-AKLDHVNIVHYNGCWDGFDYDP 80 Query: 423 -------SESHRGHLFVCVTLCEQ-TLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 S S LF+ + C++ TLE ++ RGE ++ A + I K V Sbjct: 81 ETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKV---LALELFEQITKGVDY 137 Query: 475 LHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 +H S ++DL+P NI + K + DF Sbjct: 138 IH-SKKLINRDLKPSNIFLVDTKQVKIGDF 166 >4BSZ-B nrPDB Length = 202 Score = 36.6 bits (83), Expect = 0.044, Method: Compositional matrix adjust. Identities = 24/83 (28%), Positives = 41/83 (49%) Query: 127 TAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKI 186 TA AA G ++ ++++ + + N K + K G TAL A+ G ++V+K+ Sbjct: 54 TALHMAAANGHIETVRYILETVSRANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVVKL 113 Query: 187 LLDEMGADVNACDNMGRNALIHA 209 L DE AD + G +A+ A Sbjct: 114 LCDEYEADPFIRNKFGHDAIFEA 136 >2F9G-A nrPDB Length = 353 Score = 36.6 bits (83), Expect = 0.046, Method: Compositional matrix adjust. Identities = 26/105 (24%), Positives = 48/105 (45%), Gaps = 3/105 (2%) Query: 400 RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDE 459 R RE+ L+ + + + F F V + ++ ++ D+HR + D+ Sbjct: 55 RTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQT--DLHRVISTQMLSDD 112 Query: 460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 + + +AV+ LH S H+DL+P N+LI+S + DF Sbjct: 113 HIQYFIYQTLRAVKVLHGS-NVIHRDLKPSNLLINSNCDLKVCDF 156 >6E9W-A nrPDB Length = 443 Score = 36.2 bits (82), Expect = 0.049, Method: Compositional matrix adjust. Identities = 17/52 (32%), Positives = 31/52 (59%), Gaps = 1/52 (1%) Query: 458 DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK 509 +++AR + + A+ +H S G+ H+D++P N+L+D LADF +K Sbjct: 200 EKWARFYTAEVVLALDAIH-SMGFIHRDVKPDNMLLDKSGHLKLADFGTCMK 250 >1NY3-A nrPDB Length = 400 Score = 36.2 bits (82), Expect = 0.053, Method: Compositional matrix adjust. Identities = 38/151 (25%), Positives = 66/151 (43%), Gaps = 12/151 (7%) Query: 365 IDEKYKIADTSEG----GIYLGFYEK--QEVAVKTFCEGSPRAQREVSCLQSSRENSHLV 418 I + YK+ G G L + K QE + P+A+REV + + H+V Sbjct: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIV 118 Query: 419 TFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENE--EDEFARNVLSSIFKAVQELH 476 + C+ + + L+ R +D ++ + A ++ SI +A+Q LH Sbjct: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 Query: 477 LSCGYTHQDLQPQNILIDSKKA---AHLADF 504 S H+D++P+N+L SK+ L DF Sbjct: 179 -SINIAHRDVKPENLLYTSKRPNAILKLTDF 208 >1FVR-A nrPDB Length = 327 Score = 36.2 bits (82), Expect = 0.054, Method: Compositional matrix adjust. Identities = 27/105 (25%), Positives = 44/105 (41%), Gaps = 15/105 (14%) Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFA-RNVLSSIFKAVQE 474 +++ G+ HRG+L++ + LD R V + FA N +S + Q Sbjct: 87 NIINLLGACEHRGYLYLAIEYAPHG--NLLDFLRKSRVLETDPAFAIANSTASTLSSQQL 144 Query: 475 LHLSCG------------YTHQDLQPQNILIDSKKAAHLADFDKS 507 LH + + H+DL +NIL+ A +ADF S Sbjct: 145 LHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLS 189 >2OZA-A nrPDB Length = 356 Score = 36.2 bits (82), Expect = 0.056, Method: Compositional matrix adjust. Identities = 38/151 (25%), Positives = 66/151 (43%), Gaps = 12/151 (7%) Query: 365 IDEKYKIADTSEG----GIYLGFYEK--QEVAVKTFCEGSPRAQREVSCLQSSRENSHLV 418 I + YK+ G G L + K QE + P+A+REV + + H+V Sbjct: 15 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIV 74 Query: 419 TFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENE--EDEFARNVLSSIFKAVQELH 476 + C+ + + L+ R +D ++ + A ++ SI +A+Q LH Sbjct: 75 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 477 LSCGYTHQDLQPQNILIDSKKA---AHLADF 504 S H+D++P+N+L SK+ L DF Sbjct: 135 -SINIAHRDVKPENLLYTSKRPNAILKLTDF 164 >1G3N-B nrPDB Length = 168 Score = 36.2 bits (82), Expect = 0.057, Method: Compositional matrix adjust. Identities = 33/102 (32%), Positives = 47/102 (46%), Gaps = 1/102 (0%) Query: 59 GWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADV 118 G T L +++ +I LL GA+P L+ + G AA AG + L+ L ADV Sbjct: 38 GRTALQ-VMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADV 96 Query: 119 NECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKED 160 N D G AA G ++ ++FL K A+ R K D Sbjct: 97 NIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGD 138 >5IG1-A nrPDB Length = 344 Score = 36.2 bits (82), Expect = 0.057, Method: Compositional matrix adjust. Identities = 59/225 (26%), Positives = 97/225 (43%), Gaps = 48/225 (21%) Query: 400 RAQREVSCLQSSRENSHLVTF---YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENE 456 + +RE+ + SS ++ H+V+ + ESH +F V+ E D NE Sbjct: 62 KIKREIG-ICSSLQHEHIVSMRRAFRDESHFYLVFEYVSGGE-----LFDEIVTRKFYNE 115 Query: 457 EDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK---KAAHLADFDKSI----- 508 +D A + I A+Q H S H+DL+P+N+L+ SK + DF ++ Sbjct: 116 KD--ASACMHQILSALQHCH-SKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQG 172 Query: 509 ----KWAGDP----QEVKR--------DLEDLGRLVLYVVKKGSISF-----EDLKAQ-S 546 +AG P EV R D+ G ++LY++ G F + L AQ Sbjct: 173 PTYFGFAGTPGYLSPEVIRRVPYDTAVDVWACG-VILYILLVGYPPFWEEDHQKLYAQIK 231 Query: 547 NEEVVQLSPDEET-----KDLIHRLFHPGEHVRDCLSDLLGHPFF 586 N + SP+ ++ K+LI + P R + +LL HP+ Sbjct: 232 NCQYDFPSPEWDSVTTAAKELIKAMLEPNPKRRPTVQELLQHPWI 276 >2W96-B nrPDB Length = 306 Score = 36.2 bits (82), Expect = 0.057, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 27/46 (58%), Gaps = 1/46 (2%) Query: 459 EFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 E ++++ + + LH +C H+DL+P+NIL+ S LADF Sbjct: 112 ETIKDLMRQFLRGLDFLHANC-IVHRDLKPENILVTSGGTVKLADF 156 >4YNZ-A nrPDB Length = 342 Score = 36.2 bits (82), Expect = 0.059, Method: Compositional matrix adjust. Identities = 25/114 (21%), Positives = 55/114 (48%), Gaps = 6/114 (5%) Query: 400 RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDE 459 + +RE++ L+ E+ H++ + ++ +L++ + V +G E + Sbjct: 55 KVEREIAILKLI-EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARK 113 Query: 460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD 513 F R ++S++ + S H+DL+P+N+L+D + +ADF + GD Sbjct: 114 FFRQIISAL-----DFCHSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGD 162 >5CLR-A nrPDB Length = 451 Score = 36.2 bits (82), Expect = 0.059, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 26/44 (59%), Gaps = 1/44 (2%) Query: 464 VLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 ++ S+ V++ H G H+DL+P NI++D+ HL DF S Sbjct: 181 IMISVCHQVKQFH-ELGLIHRDLKPGNIMLDADMQCHLVDFGSS 223 >6BOA-A nrPDB Length = 742 Score = 35.8 bits (81), Expect = 0.062, Method: Compositional matrix adjust. Identities = 45/165 (27%), Positives = 71/165 (43%), Gaps = 14/165 (8%) Query: 88 RKKNGATPFILAAIAGSVKLL-KLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYK 146 +K+ +P +LAA V+ L KL + V++ G TA AA+Y ++A L + Sbjct: 41 QKRIWESPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLME 100 Query: 147 RGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGA-DVNACDNMGRNA 205 + T E E G TAL A ++ +++ LL + A R + Sbjct: 101 AAPELVFEPMTSELYE-----GQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRS 155 Query: 206 ---LI----HALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPL 243 LI H L + + E I LL++HGAD+ + G T L Sbjct: 156 PCNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVL 200 Score = 31.6 bits (70), Expect = 1.2, Method: Compositional matrix adjust. Identities = 28/95 (29%), Positives = 46/95 (48%), Gaps = 4/95 (4%) Query: 210 LLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDT 269 LL++ D+DV+A+ LL V+ RG G+T L +A +L L+E + + Sbjct: 50 LLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEP 109 Query: 270 DS----DGKTALLLAVELKLKKIAELLCKRGASTD 300 + +G+TAL +AV + + L R AS Sbjct: 110 MTSELYEGQTALHIAVVNQNMNLVRALLARRASVS 144 Score = 31.6 bits (70), Expect = 1.2, Method: Compositional matrix adjust. Identities = 46/186 (24%), Positives = 78/186 (41%), Gaps = 24/186 (12%) Query: 125 GFTAFMEAAVYGKVKALKFLYKRGANVNLR---RKTKEDQERLRKGGATALMDAAEKGHV 181 G TA A V + ++ L R A+V+ R + L G L AA Sbjct: 117 GQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSE 176 Query: 182 EVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLD---HGADVN----V 234 E++++L+ E GAD+ A D++G L +L + + + +LLL HG + V Sbjct: 177 EIVRLLI-EHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHGDHLQPLDLV 235 Query: 235 RGERGKTPLILAVEKKHLGLVQRLLEQEH-------------IEINDTDSDGKTALLLAV 281 +G TP LA + + + Q L+++ ++ + DS G LL + Sbjct: 236 PNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTLYDLTEIDSSGDEQSLLEL 295 Query: 282 ELKLKK 287 + KK Sbjct: 296 IITTKK 301 Score = 30.8 bits (68), Expect = 2.2, Method: Compositional matrix adjust. Identities = 21/65 (32%), Positives = 34/65 (52%), Gaps = 12/65 (18%) Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWT------------PLHNAVQMSREDIVELLL 79 AV N++++LV+ LL A+V+ + + PL A ++ E+IV LL+ Sbjct: 124 AVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVRLLI 183 Query: 80 RHGAD 84 HGAD Sbjct: 184 EHGAD 188 >4C0T-A nrPDB Length = 974 Score = 35.8 bits (81), Expect = 0.066, Method: Compositional matrix adjust. Identities = 17/47 (36%), Positives = 28/47 (59%), Gaps = 1/47 (2%) Query: 458 DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 +E R+ + I A++ +H G H+DL+P+NIL+D K + DF Sbjct: 366 EECTRHFGAQILDAIKYMH-DNGVIHRDLKPENILLDDKMRIQITDF 411 >4RC3-A nrPDB Length = 289 Score = 35.8 bits (81), Expect = 0.068, Method: Compositional matrix adjust. Identities = 18/49 (36%), Positives = 31/49 (63%), Gaps = 2/49 (4%) Query: 457 EDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILID-SKKAAHLADF 504 ++E AR+ + +AV+ H +CG H+D++ +NILID ++ L DF Sbjct: 116 QEELARSFFWQVLEAVRHCH-NCGVLHRDIKDENILIDLNRGELKLIDF 163 >3BGP-A nrPDB Length = 333 Score = 35.8 bits (81), Expect = 0.071, Method: Compositional matrix adjust. Identities = 18/49 (36%), Positives = 31/49 (63%), Gaps = 2/49 (4%) Query: 457 EDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILID-SKKAAHLADF 504 ++E AR+ + +AV+ H +CG H+D++ +NILID ++ L DF Sbjct: 160 QEELARSFFWQVLEAVRHCH-NCGVLHRDIKDENILIDLNRGELKLIDF 207 >3KA0-A nrPDB Length = 320 Score = 35.8 bits (81), Expect = 0.072, Method: Compositional matrix adjust. Identities = 38/151 (25%), Positives = 66/151 (43%), Gaps = 12/151 (7%) Query: 365 IDEKYKIADTSEG----GIYLGFYEK--QEVAVKTFCEGSPRAQREVSCLQSSRENSHLV 418 I + YK+ G G L + K QE + P+A+REV + + H+V Sbjct: 13 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIV 72 Query: 419 TFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENE--EDEFARNVLSSIFKAVQELH 476 + C+ + + L+ R +D ++ + A ++ SI +A+Q LH Sbjct: 73 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 132 Query: 477 LSCGYTHQDLQPQNILIDSKKA---AHLADF 504 S H+D++P+N+L SK+ L DF Sbjct: 133 -SINIAHRDVKPENLLYTSKRPNAILKLTDF 162 >2YZA-A nrPDB Length = 276 Score = 35.8 bits (81), Expect = 0.073, Method: Compositional matrix adjust. Identities = 29/110 (26%), Positives = 50/110 (45%), Gaps = 10/110 (9%) Query: 400 RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCE--QTLEACLDVHRGEDVENEE 457 + +RE+ L+ R + H++ Y S F+ + + + R E++E Sbjct: 57 KIKREIQNLKLFR-HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEME--- 112 Query: 458 DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 AR + I AV H H+DL+P+N+L+D+ A +ADF S Sbjct: 113 ---ARRLFQQILSAVDYCHRHM-VVHRDLKPENVLLDAHMNAKIADFGLS 158 >2PL0-A nrPDB Length = 289 Score = 35.8 bits (81), Expect = 0.073, Method: Compositional matrix adjust. Identities = 46/204 (22%), Positives = 83/204 (40%), Gaps = 37/204 (18%) Query: 377 GGIYLGFYEKQ-EVAVKTFCEGS--PRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVC 433 G +++G+Y +VAVK+ +GS P A + L ++ LV Y + + Sbjct: 37 GEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIIT 96 Query: 434 VTLCEQTLEACLDVHRGEDVE-NEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNIL 492 + +L L G + N+ + A + + ++E + Y H+DL+ NIL Sbjct: 97 EYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGM-AFIEERN----YIHRDLRAANIL 151 Query: 493 IDSKKAAHLADFDKS-----------------IKWAGDPQ-------EVKRDLEDLGRLV 528 + + +ADF + IKW P+ +K D+ G L+ Sbjct: 152 VSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTA-PEAINYGTFTIKSDVWSFGILL 210 Query: 529 LYVVKKGSISFEDLKAQSNEEVVQ 552 +V G I + + +N EV+Q Sbjct: 211 TEIVTHGRIPYPGM---TNPEVIQ 231 >6BDL-A nrPDB Length = 347 Score = 35.8 bits (81), Expect = 0.076, Method: Compositional matrix adjust. Identities = 24/70 (34%), Positives = 37/70 (52%), Gaps = 10/70 (14%) Query: 441 LEACLDVHRGE------DVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILID 494 +EACL GE D + ED R + + +A LH S G ++DL+P+N+++D Sbjct: 114 MEACLG---GELWTILRDRGSFEDSTTRFYTACVVEAFAYLH-SKGIIYRDLKPENLILD 169 Query: 495 SKKAAHLADF 504 + A L DF Sbjct: 170 HRGYAKLVDF 179 >2BPM-A nrPDB Length = 309 Score = 35.4 bits (80), Expect = 0.086, Method: Compositional matrix adjust. Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 10/121 (8%) Query: 387 QEVAVKTFCEGSPR-AQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACL 445 +++ + T EG P A RE+S L+ + ++V L++ Q L+ + Sbjct: 38 KKIRLDTETEGVPSTAIREISLLKE-LNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFM 96 Query: 446 DVHRGEDVENEEDEFARNVLSSIFKAVQELHL--SCGYTHQDLQPQNILIDSKKAAHLAD 503 D + + S +F+ +Q L S H+DL+PQN+LI+++ A LAD Sbjct: 97 DASALTGIP------LPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLAD 150 Query: 504 F 504 F Sbjct: 151 F 151 >6CQF-A nrPDB Length = 297 Score = 35.4 bits (80), Expect = 0.087, Method: Compositional matrix adjust. Identities = 31/107 (28%), Positives = 53/107 (49%), Gaps = 8/107 (7%) Query: 402 QREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLC-EQTLEACLDVHRGEDVENEEDEF 460 Q+E+ L++ R ++++V ++GS L++C+ C +L+ V G E + Sbjct: 61 QKEILILKTCR-HANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQV-TGSLSELQISYV 118 Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 R VL + + LH S H+D++ NILI+ LADF S Sbjct: 119 CREVL----QGLAYLH-SQKKIHRDIKGANILINDAGEVRLADFGIS 160 >3PPZ-A nrPDB Length = 309 Score = 35.4 bits (80), Expect = 0.088, Method: Compositional matrix adjust. Identities = 38/151 (25%), Positives = 68/151 (45%), Gaps = 11/151 (7%) Query: 365 IDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQR------EVSCLQSSRENSHLV 418 ++ K KI S G ++ + +VAVK E A+R EV+ ++ R + ++V Sbjct: 39 LNIKEKIGAGSFGTVHRAEWHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLR-HPNIV 97 Query: 419 TFYGSESHRGHL-FVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH- 476 F G+ + +L V L +L L H+ E ++ ++ + K + LH Sbjct: 98 LFMGAVTQPPNLSIVTEYLSRGSLYRLL--HKSGAREQLDERRRLSMAYDVAKGMNYLHN 155 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 + H+DL+ N+L+D K + DF S Sbjct: 156 RNPPIVHRDLKSPNLLVDKKYTVKVCDFGLS 186 >5TUR-A nrPDB Length = 404 Score = 35.4 bits (80), Expect = 0.094, Method: Compositional matrix adjust. Identities = 18/49 (36%), Positives = 31/49 (63%), Gaps = 2/49 (4%) Query: 457 EDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILID-SKKAAHLADF 504 ++E AR+ + +AV+ H +CG H+D++ +NILID ++ L DF Sbjct: 231 QEELARSFFWQVLEAVRHCH-NCGVLHRDIKDENILIDLNRGELKLIDF 278 >6DVZ-A nrPDB Length = 791 Score = 35.0 bits (79), Expect = 0.11, Method: Compositional matrix adjust. Identities = 24/71 (33%), Positives = 31/71 (43%), Gaps = 14/71 (19%) Query: 221 ITHLLLDHGADVNVRGE--------------RGKTPLILAVEKKHLGLVQRLLEQEHIEI 266 IT +L+ GADVN + G+TPL LA +VQ L+E E +I Sbjct: 230 ITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDI 289 Query: 267 NDTDSDGKTAL 277 DS G L Sbjct: 290 TSQDSRGNNIL 300 Score = 28.5 bits (62), Expect = 10.0, Method: Compositional matrix adjust. Identities = 29/99 (29%), Positives = 47/99 (47%), Gaps = 13/99 (13%) Query: 28 LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQM-----SREDIVE-----L 77 L + A N+ ++VQ L+E ++ G LH V + ++ D V+ + Sbjct: 266 LALAACTNQP-EIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMI 324 Query: 78 LLRHGADPV--LRKKNGATPFILAAIAGSVKLLKLFLSK 114 LLR G + +R +G TP LAA G ++LK LS+ Sbjct: 325 LLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSR 363 >2BRG-A nrPDB Length = 297 Score = 35.0 bits (79), Expect = 0.12, Method: Compositional matrix adjust. Identities = 27/111 (24%), Positives = 50/111 (45%), Gaps = 15/111 (13%) Query: 399 PRAQREVSCLQSSRENSHLVTFYG--SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENE 456 P ++ C+ + ++V FYG E + +LF LE C + +E + Sbjct: 49 PENIKKEICINKMLNHENVVKFYGHRREGNIQYLF---------LEYCSGGELFDRIEPD 99 Query: 457 ---EDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 + A+ + V LH G TH+D++P+N+L+D + ++DF Sbjct: 100 IGMPEPDAQRFFHQLMAGVVYLH-GIGITHRDIKPENLLLDERDNLKISDF 149 >6G1K-A nrPDB Length = 921 Score = 35.0 bits (79), Expect = 0.12, Method: Compositional matrix adjust. Identities = 30/82 (36%), Positives = 42/82 (51%), Gaps = 6/82 (7%) Query: 246 AVEKKHLGLVQRLLEQEHI----EINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC 301 AVEK V+ LE+ I IN D G+TALL+A+E + +I ELL Sbjct: 39 AVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAIENENLEIIELLLSFNVYV-- 96 Query: 302 GDLVMTARRNYDHSLVKVLLSH 323 GD ++ A R V++LL+H Sbjct: 97 GDALLHAIRKEVVGAVELLLNH 118 Score = 34.7 bits (78), Expect = 0.16, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 21/103 (20%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHG------ 82 L+ A++NE++++++ LL V L +A++ VELLL H Sbjct: 74 LLIAIENENLEIIELLLSFNVYVG--------DALLHAIRKEVVGAVELLLNHKKPSGEK 125 Query: 83 -ADPVLRKKNGA------TPFILAAIAGSVKLLKLFLSKGADV 118 P+L K + TP ILAA + +++K+ + KG V Sbjct: 126 QVPPILLDKQFSDFTPDITPIILAAHTNNYEIIKMLVQKGVSV 168 >5LOH-A nrPDB Length = 341 Score = 35.0 bits (79), Expect = 0.12, Method: Compositional matrix adjust. Identities = 46/174 (26%), Positives = 76/174 (43%), Gaps = 19/174 (10%) Query: 344 GAALKD-LHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEG----- 397 GAA ++ ++RI P ++ F K I+ + G +YLG + AVK + Sbjct: 17 GAATEEGVNRIAVPKPPSIEEFSIVK-PISRGAFGKVYLGQKGGKLYAVKVVKKADMINK 75 Query: 398 ----SPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDV 453 +A+R+ L S HL +Y +S V L +++ L ++ D Sbjct: 76 NMTHQVQAERDALALSKSPFIVHL--YYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFD- 132 Query: 454 ENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 +E A +S + A+ LH G H+DL+P N+LI ++ L DF S Sbjct: 133 ----EEMAVKYISEVALALDYLH-RHGIIHRDLKPDNMLISNEGHIKLTDFGLS 181 >4QNY-A nrPDB Length = 354 Score = 35.0 bits (79), Expect = 0.12, Method: Compositional matrix adjust. Identities = 20/78 (25%), Positives = 40/78 (51%), Gaps = 10/78 (12%) Query: 429 HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL--SCGYTHQDL 486 H ++ + + E L+ L G+++ +F I++A++ LH+ S G H+D+ Sbjct: 100 HFYIVMDIMETDLKQVL--RSGQELTEAHIQFF------IYQALRALHIIHSAGVIHRDI 151 Query: 487 QPQNILIDSKKAAHLADF 504 P NIL+++ + DF Sbjct: 152 TPANILVNTNCDLKICDF 169 >6CTH-A nrPDB Length = 309 Score = 35.0 bits (79), Expect = 0.13, Method: Compositional matrix adjust. Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 14/144 (9%) Query: 370 KIADTSEGGIYLGFYEKQE--VAVKTFCEGSPRAQREVSC---LQSSRENSHLVTFYGSE 424 K+ + G +Y GF + +AVK S + +E + + S + +LV G Sbjct: 22 KLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLRHKNLVKLIGWC 81 Query: 425 SHRGHLFVCVTLCEQTLEACLDVH--RGEDVENEEDEFARNVLSSIFKAVQELHLSCGYT 482 RG L + + E LD H +G+ + E + ++ + A+ LH + Sbjct: 82 HERGELML---VYEFMANGSLDSHIFKGKSLLTWEVRY--RIVKDLASALLYLHEEGDHC 136 Query: 483 --HQDLQPQNILIDSKKAAHLADF 504 H+D++ NI++DS A L DF Sbjct: 137 VLHRDIKTSNIMLDSSFNAKLGDF 160 >6BXI-A nrPDB Length = 333 Score = 35.0 bits (79), Expect = 0.13, Method: Compositional matrix adjust. Identities = 14/34 (41%), Positives = 23/34 (67%), Gaps = 1/34 (2%) Query: 471 AVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 A+ +H G+ H+D++P N+L+DSK L+DF Sbjct: 118 AIDSIH-QLGFIHRDIKPDNLLLDSKGHVKLSDF 150 >5EZV-A nrPDB Length = 560 Score = 35.0 bits (79), Expect = 0.13, Method: Compositional matrix adjust. Identities = 19/51 (37%), Positives = 28/51 (54%), Gaps = 1/51 (1%) Query: 457 EDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 E+ AR + I AV H H+DL+P+N+L+D+ A +ADF S Sbjct: 126 EEMEARRLFQQILSAVDYCHRHM-VVHRDLKPENVLLDAHMNAKIADFGLS 175 >4CFF-A nrPDB Length = 571 Score = 35.0 bits (79), Expect = 0.13, Method: Compositional matrix adjust. Identities = 19/51 (37%), Positives = 28/51 (54%), Gaps = 1/51 (1%) Query: 457 EDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 E+ AR + I AV H H+DL+P+N+L+D+ A +ADF S Sbjct: 131 EEMEARRLFQQILSAVDYCHRHM-VVHRDLKPENVLLDAHMNAKIADFGLS 180 >4AZW-A nrPDB Length = 471 Score = 34.7 bits (78), Expect = 0.14, Method: Compositional matrix adjust. Identities = 16/55 (29%), Positives = 34/55 (61%), Gaps = 7/55 (12%) Query: 450 GEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 GE+++ E+ +L S+ +++ L G+ H D++P N+++D+++ A L DF Sbjct: 336 GEEIDREK------ILGSLLRSLAALE-KKGFWHDDVRPWNVMVDARQHARLIDF 383 >4AZV-A nrPDB Length = 569 Score = 34.7 bits (78), Expect = 0.15, Method: Compositional matrix adjust. Identities = 16/55 (29%), Positives = 34/55 (61%), Gaps = 7/55 (12%) Query: 450 GEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 GE+++ E+ +L S+ +++ L G+ H D++P N+++D+++ A L DF Sbjct: 336 GEEIDREK------ILGSLLRSLAALE-KQGFWHDDVRPWNVMVDARQHARLIDF 383 >1S9I-A nrPDB Length = 354 Score = 34.7 bits (78), Expect = 0.15, Method: Compositional matrix adjust. Identities = 26/105 (24%), Positives = 48/105 (45%), Gaps = 5/105 (4%) Query: 403 REVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFAR 462 RE+ L + ++V FYG+ G + +C+ E LD ++ + +E Sbjct: 63 RELQVLHECN-SPYIVGFYGAFYSDGEISICM---EHMDGGSLD-QVLKEAKRIPEEILG 117 Query: 463 NVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 V ++ + + L H+D++P NIL++S+ L DF S Sbjct: 118 KVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVS 162 >6DJS-A nrPDB Length = 676 Score = 34.7 bits (78), Expect = 0.16, Method: Compositional matrix adjust. Identities = 46/182 (25%), Positives = 85/182 (46%), Gaps = 43/182 (23%) Query: 172 LMDAAEKGHVEVLKILLDEMGA-DVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGA 230 +DAAE G++ V++ +L+E +VN D MG+NAL L+ + +E +T LLL Sbjct: 48 FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNAL---QLAVGNEHLE-VTELLLKKE- 102 Query: 231 DVNVRGERGKTPLILAVEKKHLGLVQRLLE---------------QEHIEIND---TDSD 272 N+ R L+LA+ K ++ +V+ +L ++ ++ +D D D Sbjct: 103 --NL--ARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDED 158 Query: 273 GK------TALLLAVELKLKKIAELLCKRGASTD--------CGDLVMTARRN-YDHSLV 317 G T ++LA + ++ +L +GA + CGD + R + + HS Sbjct: 159 GTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRS 218 Query: 318 KV 319 ++ Sbjct: 219 RI 220 Score = 32.0 bits (71), Expect = 1.1, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 50/98 (51%), Gaps = 5/98 (5%) Query: 227 DHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQ-EHIEINDTDSDGKTALLLAVELKL 285 D G + ER + A E ++ +V+++LE+ + + +N D G+ AL LAV + Sbjct: 36 DRGTSLTAEEER----FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEH 91 Query: 286 KKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSH 323 ++ ELL K+ GD ++ A +V+ +L+H Sbjct: 92 LEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNH 129 >3QGY-A nrPDB Length = 286 Score = 34.7 bits (78), Expect = 0.17, Method: Compositional matrix adjust. Identities = 52/214 (24%), Positives = 86/214 (40%), Gaps = 43/214 (20%) Query: 370 KIADTSEGGIYLGFY-EKQEVAVKTFCEGSPRAQREVSCLQSSRENSH--LVTFYGSESH 426 +I G ++LG++ K +VA+KT EGS + + + SH LV YG Sbjct: 34 EIGSGQFGLVHLGYWLNKDKVAIKTIKEGSMSEDDFIEEAEVMMKLSHPKLVQLYGVCLE 93 Query: 427 RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE----LHLSCGYT 482 + + + E CL + + + FA L + V E L +C Sbjct: 94 QAPICLVFEFMEH---GCLS----DYLRTQRGLFAAETLLGMCLDVCEGMAYLEEAC-VI 145 Query: 483 HQDLQPQNILIDSKKAAHLADFDKS-----------------IKWAGDPQ-------EVK 518 H+DL +N L+ + ++DF + +KWA P+ K Sbjct: 146 HRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWA-SPEVFSFSRYSSK 204 Query: 519 RDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQ 552 D+ G L+ V +G I +E+ +SN EVV+ Sbjct: 205 SDVWSFGVLMWEVFSEGKIPYEN---RSNSEVVE 235 >5WAX-A nrPDB Length = 310 Score = 34.7 bits (78), Expect = 0.17, Method: Compositional matrix adjust. Identities = 44/168 (26%), Positives = 64/168 (38%), Gaps = 42/168 (25%) Query: 457 EDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHL--ADFDKSIK----- 509 EDE AR + V H S H+DL+ +N L+D A L DF S Sbjct: 106 EDE-ARFFFQQLISGVSYCH-SMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHS 163 Query: 510 ----WAGDPQEVKRDL----EDLGRL--------VLYVVKKGSISFEDLKAQSN------ 547 G P + ++ E G++ LYV+ G+ FED N Sbjct: 164 QPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQ 223 Query: 548 ---------EEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + V +SP E +DLI R+F R + ++ HP+F Sbjct: 224 RILGVQYSIPDYVHISP--ECQDLISRIFVANPATRITIPEIRNHPWF 269 >4N5Q-A nrPDB Length = 257 Score = 34.3 bits (77), Expect = 0.18, Method: Compositional matrix adjust. Identities = 24/71 (33%), Positives = 31/71 (43%), Gaps = 14/71 (19%) Query: 221 ITHLLLDHGADVNVRGE--------------RGKTPLILAVEKKHLGLVQRLLEQEHIEI 266 IT +L+ GADVN + G+TPL LA +VQ L+E E +I Sbjct: 114 ITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDI 173 Query: 267 NDTDSDGKTAL 277 DS G L Sbjct: 174 TSQDSRGNNIL 184 Score = 28.9 bits (63), Expect = 7.6, Method: Compositional matrix adjust. Identities = 26/88 (29%), Positives = 41/88 (46%), Gaps = 12/88 (13%) Query: 39 DLVQQLLEGGANVNFQEEEGGWTPLHNAVQM-----SREDIVE-----LLLRHG--ADPV 86 ++VQ L+E ++ G LH V + ++ D V+ +LLR G Sbjct: 160 EIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELET 219 Query: 87 LRKKNGATPFILAAIAGSVKLLKLFLSK 114 +R +G TP LAA G ++LK LS+ Sbjct: 220 MRNNDGLTPLQLAAKMGKAEILKYILSR 247 >3EB0-A nrPDB Length = 383 Score = 34.3 bits (77), Expect = 0.19, Method: Compositional matrix adjust. Identities = 18/46 (39%), Positives = 29/46 (63%), Gaps = 2/46 (4%) Query: 465 LSSIFKAVQELHLSCGYTHQDLQPQNILIDSK-KAAHLADFDKSIK 509 + +F+AV +H S G H+D++PQN+L++SK L DF + K Sbjct: 147 IYQLFRAVGFIH-SLGICHRDIKPQNLLVNSKDNTLKLCDFGSAKK 191 >1PHK-A nrPDB Length = 298 Score = 34.3 bits (77), Expect = 0.19, Method: Compositional matrix adjust. Identities = 19/61 (31%), Positives = 32/61 (52%), Gaps = 3/61 (4%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRD 520 R ++ ++ + + LH H+DL+P+NIL+D L DF S + DP E R+ Sbjct: 126 TRKIMRALLEVICALH-KLNIVHRDLKPENILLDDDMNIKLTDFGFSCQL--DPGEKLRE 182 Query: 521 L 521 + Sbjct: 183 V 183 >5D9K-A nrPDB Length = 330 Score = 34.3 bits (77), Expect = 0.19, Method: Compositional matrix adjust. Identities = 27/80 (33%), Positives = 38/80 (47%), Gaps = 12/80 (15%) Query: 437 CEQTLEACLDVHRGED---------VENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQ 487 E L LD RG D + EED + L+ + A+ LH S G ++DL+ Sbjct: 103 TEGKLYLILDFLRGGDLFTRLSKEVMFTEED--VKFYLAELALALDHLH-SLGIIYRDLK 159 Query: 488 PQNILIDSKKAAHLADFDKS 507 P+NIL+D + L DF S Sbjct: 160 PENILLDEEGHIKLTDFGLS 179 >4M7I-A nrPDB Length = 299 Score = 34.3 bits (77), Expect = 0.20, Method: Compositional matrix adjust. Identities = 24/81 (29%), Positives = 38/81 (46%), Gaps = 4/81 (4%) Query: 425 SHRGHLFVCVTLCEQTLEACLDVHRGE-DVENEEDEFARNVLSSIFKAVQELHLSCGYTH 483 S + +L++ + LC + E D G +E E ++ I +AV+ LH S G H Sbjct: 85 SPKVYLYIQMQLCRK--ENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLH-SKGLMH 141 Query: 484 QDLQPQNILIDSKKAAHLADF 504 +DL+P NI + DF Sbjct: 142 RDLKPSNIFFTMDDVVKVGDF 162 >3QD2-B nrPDB Length = 332 Score = 33.9 bits (76), Expect = 0.29, Method: Compositional matrix adjust. Identities = 24/81 (29%), Positives = 41/81 (50%), Gaps = 4/81 (4%) Query: 425 SHRGHLFVCVTLCEQTLEACLD-VHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTH 483 S + +L++ + LC + E D ++R +E+ E ++ I +AV+ LH S G H Sbjct: 131 SPKVYLYIQMQLCRK--ENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLH-SKGLMH 187 Query: 484 QDLQPQNILIDSKKAAHLADF 504 +DL+P NI + DF Sbjct: 188 RDLKPSNIFFTMDDVVKVGDF 208 >4XD0-A nrPDB Length = 417 Score = 33.9 bits (76), Expect = 0.29, Method: Compositional matrix adjust. Identities = 22/75 (29%), Positives = 41/75 (54%), Gaps = 6/75 (8%) Query: 86 VLRKKN--GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVY----GKVK 139 +L +KN G +P I+AA G++ +++ +SKG ++N+ ++ G T M Y G Sbjct: 316 ILFEKNHLGWSPIIIAAYHGNMDVIEWLVSKGVNINDRNYKGTTVAMYFKDYMLRSGNYT 375 Query: 140 ALKFLYKRGANVNLR 154 L+ L G ++ L+ Sbjct: 376 GLENLINLGLDLFLK 390 Score = 31.6 bits (70), Expect = 1.2, Method: Compositional matrix adjust. Identities = 16/66 (24%), Positives = 34/66 (51%), Gaps = 1/66 (1%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 ++ A +++ + + +LL+ N+ F++ GW+P+ A D++E L+ G + R Sbjct: 295 ILTACEDKSPEFISKLLKT-ENILFEKNHLGWSPIIIAAYHGNMDVIEWLVSKGVNINDR 353 Query: 89 KKNGAT 94 G T Sbjct: 354 NYKGTT 359 >5J5T-A nrPDB Length = 370 Score = 33.5 bits (75), Expect = 0.30, Method: Compositional matrix adjust. Identities = 29/108 (26%), Positives = 52/108 (48%), Gaps = 8/108 (7%) Query: 401 AQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQ-TLEACLDVHRGEDVENEEDE 459 Q+E+ ++ + + ++V ++GS R L++C+ C +L+ V G E + Sbjct: 48 VQQEIIMMKDCK-HPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHV-TGPLSELQIAY 105 Query: 460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 +R L ++ LH S G H+D++ NIL+ LADF S Sbjct: 106 VSRETLQGLYY----LH-SKGKMHRDIKGANILLTDNGHVKLADFGVS 148 >5DBX-A nrPDB Length = 328 Score = 33.5 bits (75), Expect = 0.32, Method: Compositional matrix adjust. Identities = 30/108 (27%), Positives = 52/108 (48%), Gaps = 11/108 (10%) Query: 408 LQSSRENSH--LVTFYGSESHRGHLFVCVTLCEQTLEACLD-----VHRGEDVENE-EDE 459 +Q+ + SH +VT+Y S + L++ + L + LD V+RGE E+ Sbjct: 60 IQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGG--SMLDIIKYIVNRGEHKNGVLEEA 117 Query: 460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 +L + + + LH + G H+DL+ NIL+ + +ADF S Sbjct: 118 IIATILKEVLEGLDYLHRN-GQIHRDLKAGNILLGEDGSVQIADFGVS 164 >5B2L-A nrPDB Length = 324 Score = 33.5 bits (75), Expect = 0.32, Method: Compositional matrix adjust. Identities = 26/112 (23%), Positives = 48/112 (42%), Gaps = 4/112 (3%) Query: 396 EGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVEN 455 E + R ++ + S + ++V +G+ +F+ + L + E +G E Sbjct: 57 EENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTSAEKLKKRMQGPIPER 116 Query: 456 EEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 + +I KA+ L G H+D++P NIL+D + L DF S Sbjct: 117 ----ILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGIS 164 >3A8W-A nrPDB Length = 345 Score = 33.5 bits (75), Expect = 0.33, Method: Compositional matrix adjust. Identities = 41/173 (23%), Positives = 70/173 (40%), Gaps = 46/173 (26%) Query: 458 DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF----------DKS 507 +E AR + I A+ LH G ++DL+ N+L+DS+ L D+ D + Sbjct: 109 EEHARFYSAEISLALNYLH-ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTT 167 Query: 508 IKWAGDPQEVKRDL---EDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLS--PDEETKDL 562 + G P + ++ ED G V + G + FE + +S ++V S PD+ T+D Sbjct: 168 STFCGTPNYIAPEILRGEDYGFSVDWWA-LGVLMFEMMAGRSPFDIVGSSDNPDQNTEDY 226 Query: 563 IHRLF-----------------------------HPGEHVRDCLSDLLGHPFF 586 + ++ G H + +D+ GHPFF Sbjct: 227 LFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFF 279 >1DCQ-A nrPDB Length = 278 Score = 33.5 bits (75), Expect = 0.33, Method: Compositional matrix adjust. Identities = 20/73 (27%), Positives = 37/73 (50%), Gaps = 1/73 (1%) Query: 27 HLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPV 86 HL +++V + +V L++ N++ Q +G T LH + ++LLLR A Sbjct: 174 HLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGS-TALHYCCLTDNAECLKLLLRGKASIE 232 Query: 87 LRKKNGATPFILA 99 + ++G TP +A Sbjct: 233 IANESGETPLDIA 245 >3OZ6-A nrPDB Length = 388 Score = 33.5 bits (75), Expect = 0.35, Method: Compositional matrix adjust. Identities = 15/41 (36%), Positives = 27/41 (65%), Gaps = 1/41 (2%) Query: 464 VLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 V+ + K ++ LH S G H+D++P NIL++++ +ADF Sbjct: 114 VVYQLIKVIKYLH-SGGLLHRDMKPSNILLNAECHVKVADF 153 >3FXW-A nrPDB Length = 336 Score = 33.5 bits (75), Expect = 0.36, Method: Compositional matrix adjust. Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 11/125 (8%) Query: 387 QEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTF---YGSESHRGHLFVCVTLCEQTLEA 443 Q+ A+K + SP+A++EV + H+V Y + H + + C + E Sbjct: 55 QKCALKLLYD-SPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGEL 113 Query: 444 CLDVH-RGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKK---AA 499 + RG+ E + A ++ I A+Q LH S H+D++P+N+L SK+ Sbjct: 114 FSRIQERGDQAFTERE--AAEIMRDIGTAIQFLH-SHNIAHRDVKPENLLYTSKEKDAVL 170 Query: 500 HLADF 504 L DF Sbjct: 171 KLTDF 175 >3LZB-A nrPDB Length = 327 Score = 33.5 bits (75), Expect = 0.37, Method: Compositional matrix adjust. Identities = 34/143 (23%), Positives = 60/143 (41%), Gaps = 25/143 (17%) Query: 377 GGIYLGFY------EKQEVAVKTFCEG-SPRAQREV---SCLQSSRENSHLVTFYGSESH 426 G +Y G + K VA+K E SP+A +E+ + + +S +N H+ G Sbjct: 29 GTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLG---- 84 Query: 427 RGHLFVCVTLCEQTLE-----ACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 +C+T Q + CL + E +N ++ N I K + L Sbjct: 85 -----ICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLE-DRRL 138 Query: 482 THQDLQPQNILIDSKKAAHLADF 504 H+DL +N+L+ + + + DF Sbjct: 139 VHRDLAARNVLVKTPQHVKITDF 161 >2HK5-A nrPDB Length = 270 Score = 33.5 bits (75), Expect = 0.37, Method: Compositional matrix adjust. Identities = 25/96 (26%), Positives = 41/96 (42%), Gaps = 28/96 (29%) Query: 481 YTHQDLQPQNILIDSKKAAHLADFDKS-----------------IKWAGDPQ-------E 516 Y H+DL+ NIL+ + +ADF + IKW P+ Sbjct: 132 YIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTA-PEAINFGSFT 190 Query: 517 VKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQ 552 +K D+ G L++ +V G I + + SN EV++ Sbjct: 191 IKSDVWSFGILLMEIVTYGRIPYPGM---SNPEVIR 223 >3HKO-A nrPDB Length = 345 Score = 33.5 bits (75), Expect = 0.39, Method: Compositional matrix adjust. Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 3/54 (5%) Query: 456 EEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA--AHLADFDKS 507 + ++ N++ IF A+ LH + G H+D++P+N L + K+ L DF S Sbjct: 165 QREKLISNIMRQIFSALHYLH-NQGICHRDIKPENFLFSTNKSFEIKLVDFGLS 217 >5GNK-A nrPDB Length = 297 Score = 33.1 bits (74), Expect = 0.40, Method: Compositional matrix adjust. Identities = 34/143 (23%), Positives = 60/143 (41%), Gaps = 25/143 (17%) Query: 377 GGIYLGFY------EKQEVAVKTFCEG-SPRAQREV---SCLQSSRENSHLVTFYGSESH 426 G +Y G + K VA+K E SP+A +E+ + + +S +N H+ G Sbjct: 33 GTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLG---- 88 Query: 427 RGHLFVCVTLCEQTLE-----ACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 +C+T Q + CL + E +N ++ N I K + L Sbjct: 89 -----ICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLE-DRRL 142 Query: 482 THQDLQPQNILIDSKKAAHLADF 504 H+DL +N+L+ + + + DF Sbjct: 143 VHRDLAARNVLVKTPQHVKITDF 165 >3ZDU-A nrPDB Length = 325 Score = 33.1 bits (74), Expect = 0.41, Method: Compositional matrix adjust. Identities = 35/127 (27%), Positives = 53/127 (41%), Gaps = 19/127 (14%) Query: 387 QEVAVKTFCEGSPR-----AQREVSCL-QSSRENSHLVTFYGSESHRGHL---FVCVTLC 437 Q VA+K F E + A RE+ L Q EN + + + HL F+ T+ Sbjct: 29 QIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVL 88 Query: 438 EQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKK 497 ++ C E + R L I +A+ LH S H+D++P+NIL+ Sbjct: 89 DELQHYC---------HGLESKRLRKYLFQILRAIDYLH-SNNIIHRDIKPENILVSQSG 138 Query: 498 AAHLADF 504 L DF Sbjct: 139 ITKLCDF 145 >3DKO-A nrPDB Length = 318 Score = 33.1 bits (74), Expect = 0.42, Method: Compositional matrix adjust. Identities = 31/134 (23%), Positives = 58/134 (43%), Gaps = 10/134 (7%) Query: 389 VAVKTFCEG-SPRAQREVSC---LQSSRENSHLVTFYGSESHRGHLFVCVTLCEQ-TLEA 443 VA+KT G + + +R+ C + ++ ++V G + + + + E L+A Sbjct: 74 VAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDA 133 Query: 444 CLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLAD 503 L H G+ + R + + + GY H+DL +NIL++S ++D Sbjct: 134 FLRKHDGQFTVIQLVGMLRGIAAGM-----RYLADMGYVHRDLAARNILVNSNLVCKVSD 188 Query: 504 FDKSIKWAGDPQEV 517 F S DP+ V Sbjct: 189 FGLSRVIEDDPEAV 202 >5FET-A nrPDB Length = 847 Score = 33.1 bits (74), Expect = 0.46, Method: Compositional matrix adjust. Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 1/52 (1%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAG 512 A+ L SI A++ LH ++DL+P+NIL+D + L DF + K G Sbjct: 635 AQFYLGSIILAIEYLH-ERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQG 685 >4MVF-A nrPDB Length = 506 Score = 33.1 bits (74), Expect = 0.47, Method: Compositional matrix adjust. Identities = 37/151 (24%), Positives = 66/151 (43%), Gaps = 16/151 (10%) Query: 359 GKL--KFFIDEKYKIADTSEGGIYLGF--YEKQEVAVK----TFCEGSPRAQREVSCLQS 410 GKL K+ IDEK + + G +Y G Q A+K + R +E+ ++ Sbjct: 53 GKLEDKYIIDEK--LGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKK 110 Query: 411 SRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFK 470 ++ ++V Y + + ++++ + LC + G E A ++ IF Sbjct: 111 -LDHPNIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKN----AATIMKQIFS 165 Query: 471 AVQELHLSCGYTHQDLQPQNILIDSKKAAHL 501 A+ LH S H+DL+P+N L S+ L Sbjct: 166 AIFYLH-SLNIVHRDLKPENFLFQSENKDSL 195 >5DYK-A nrPDB Length = 853 Score = 33.1 bits (74), Expect = 0.47, Method: Compositional matrix adjust. Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 1/52 (1%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAG 512 A+ L SI A++ LH ++DL+P+NIL+D + L DF + K G Sbjct: 641 AQFYLGSIILAIEYLH-ERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQG 691 >3KUL-B nrPDB Length = 325 Score = 33.1 bits (74), Expect = 0.49, Method: Compositional matrix adjust. Identities = 26/90 (28%), Positives = 43/90 (47%), Gaps = 7/90 (7%) Query: 427 RGHLFVCVT--LCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQ 484 RG L + VT + +L+ L H G+ + R V + + + + +L GY H+ Sbjct: 121 RGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGM-RYLSDL----GYVHR 175 Query: 485 DLQPQNILIDSKKAAHLADFDKSIKWAGDP 514 DL +N+L+DS ++DF S DP Sbjct: 176 DLAARNVLVDSNLVCKVSDFGLSRVLEDDP 205 >1VZO-A nrPDB Length = 355 Score = 33.1 bits (74), Expect = 0.51, Method: Compositional matrix adjust. Identities = 40/165 (24%), Positives = 70/165 (42%), Gaps = 32/165 (19%) Query: 370 KIADTSEGGIY-LGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTF---YGSES 425 KI+ G +Y + +K + K R +R+V L+ R++ LVT + +E+ Sbjct: 75 KISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQV--LEHIRQSPFLVTLHYAFQTET 132 Query: 426 ---------HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 + G LF ++ E+ E + ++ GE I A++ LH Sbjct: 133 KLHLILDYINGGELFTHLSQRERFTEHEVQIYVGE----------------IVLALEHLH 176 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDL 521 G ++D++ +NIL+DS L DF S ++ D E D Sbjct: 177 -KLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDF 220 >5X1R-A nrPDB Length = 302 Score = 32.7 bits (73), Expect = 0.55, Method: Compositional matrix adjust. Identities = 18/65 (27%), Positives = 32/65 (49%), Gaps = 1/65 (1%) Query: 449 RGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI 508 + + E ++ + R +L +F A+ +H GY H+D+ NI I + L DF + Sbjct: 130 QAQQPEKIDEAWIRRLLPPLFSAINTIH-QEGYLHRDISLDNIQIQESQLPVLLDFGSAR 188 Query: 509 KWAGD 513 K G+ Sbjct: 189 KEIGN 193 >4E7W-A nrPDB Length = 394 Score = 32.7 bits (73), Expect = 0.56, Method: Compositional matrix adjust. Identities = 34/152 (22%), Positives = 66/152 (43%), Gaps = 10/152 (6%) Query: 371 IADTSEGGIYLG-FYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHL---VTFYGSESH 426 I + S G ++ E EVA+K + RE+ ++ + + + FY + Sbjct: 48 IGNGSFGVVFQAKLVESDEVAIKKVLQDKRFKNRELQIMRIVKHPNVVDLKAFFYSNGDK 107 Query: 427 RGHLFVCVTLCEQTLEACLDV--HRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQ 484 + +F+ + L E E H + + + + + +++ +H S G H+ Sbjct: 108 KDEVFLNLVL-EYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIH-SIGICHR 165 Query: 485 DLQPQNILIDSKKAA-HLADFDKS-IKWAGDP 514 D++PQN+L+D L DF + I AG+P Sbjct: 166 DIKPQNLLLDPPSGVLKLIDFGSAKILIAGEP 197 >2XIK-A nrPDB Length = 294 Score = 32.7 bits (73), Expect = 0.56, Method: Compositional matrix adjust. Identities = 33/142 (23%), Positives = 65/142 (45%), Gaps = 14/142 (9%) Query: 370 KIADTSEGGIYLGF--YEKQEVAVKTF-----CEGSPRAQREVSCLQSSRENSHLVTFYG 422 +I S G +Y G + K+ VA+K + Q+E++ L S ++ ++ ++G Sbjct: 26 RIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVL-SQCDSPYITRYFG 84 Query: 423 SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYT 482 S L++ + + LD+ + +E + + +L I K + LH S Sbjct: 85 SYLKSTKLWIIMEYLGGG--SALDLLKPGPLE---ETYIATILREILKGLDYLH-SERKI 138 Query: 483 HQDLQPQNILIDSKKAAHLADF 504 H+D++ N+L+ + LADF Sbjct: 139 HRDIKAANVLLSEQGDVKLADF 160 >4UZD-A nrPDB Length = 287 Score = 32.7 bits (73), Expect = 0.58, Method: Compositional matrix adjust. Identities = 36/131 (27%), Positives = 51/131 (38%), Gaps = 28/131 (21%) Query: 483 HQDLQPQNILIDSKKAAHLADFDKSIKWAGD------------PQEV--------KRDLE 522 H+D++P+N+L+ S +ADF S+ P E+ K DL Sbjct: 131 HRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLW 190 Query: 523 DLGRLVLYVVKKGSISFEDLKAQSNEEVVQ----LSPD---EETKDLIHRLFHPGEHVRD 575 LG L Y G FE Q + + PD E +DLI RL R Sbjct: 191 SLGVLC-YEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRP 249 Query: 576 CLSDLLGHPFF 586 L ++L HP+ Sbjct: 250 MLREVLEHPWI 260 >2Z7Q-A nrPDB Length = 321 Score = 32.7 bits (73), Expect = 0.58, Method: Compositional matrix adjust. Identities = 26/80 (32%), Positives = 37/80 (46%), Gaps = 12/80 (15%) Query: 437 CEQTLEACLDVHRGEDVEN---------EEDEFARNVLSSIFKAVQELHLSCGYTHQDLQ 487 E L LD RG D+ EED + L+ + + LH S G ++DL+ Sbjct: 101 TEGKLYLILDFLRGGDLFTRLSKEVMFTEED--VKFYLAELALGLDHLH-SLGIIYRDLK 157 Query: 488 PQNILIDSKKAAHLADFDKS 507 P+NIL+D + L DF S Sbjct: 158 PENILLDEEGHIKLTDFGLS 177 >4X7Q-B nrPDB Length = 312 Score = 32.7 bits (73), Expect = 0.58, Method: Compositional matrix adjust. Identities = 40/153 (26%), Positives = 62/153 (40%), Gaps = 29/153 (18%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA-AHLADFDK------------- 506 +R + A+Q H S G H+D++ +NILID ++ A L DF Sbjct: 141 SRCFFGQVVAAIQHCH-SRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFD 199 Query: 507 SIKWAGDPQEVKR--------DLEDLGRLVLYVVKKGSISFEDLKAQSNEEV---VQLSP 555 + P+ + R + LG ++LY + G I FE + E+ +SP Sbjct: 200 GTRVYSPPEWISRHQYHALPATVWSLG-ILLYDMVCGDIPFERDQEILEAELHFPAHVSP 258 Query: 556 DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWT 588 D LI R P R L ++L P+ T Sbjct: 259 D--CCALIRRCLAPKPSSRPSLEEILLDPWMQT 289 >6ED6-A nrPDB Length = 415 Score = 32.7 bits (73), Expect = 0.66, Method: Compositional matrix adjust. Identities = 16/52 (30%), Positives = 30/52 (57%), Gaps = 1/52 (1%) Query: 458 DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK 509 +++A+ + + A+ +H S G H+D++P N+L+D LADF +K Sbjct: 186 EKWAKFYTAEVVLALDAIH-SMGLIHRDVKPDNMLLDKHGHLKLADFGTCMK 236 >4AN9-A nrPDB Length = 301 Score = 32.3 bits (72), Expect = 0.67, Method: Compositional matrix adjust. Identities = 26/105 (24%), Positives = 46/105 (43%), Gaps = 5/105 (4%) Query: 403 REVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFAR 462 RE+ L + ++V FYG+ G + +C+ E LD + ++ Sbjct: 56 RELQVLHECN-SPYIVGFYGAFYSDGEISICM---EHMDGGSLD-QVLKKAGRIPEQILG 110 Query: 463 NVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 V ++ K + L H+D++P NIL++S+ L DF S Sbjct: 111 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS 155 >2V7O-A nrPDB Length = 336 Score = 32.3 bits (72), Expect = 0.67, Method: Compositional matrix adjust. Identities = 20/58 (34%), Positives = 33/58 (56%), Gaps = 4/58 (6%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK---KAAHLADFDKSIKWAGDPQ 515 A + + I ++V +H H+DL+P+N+L+ SK A LADF +I+ G+ Q Sbjct: 132 ASHCIHQILESVNHIHQH-DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQ 188 >2R2P-A nrPDB Length = 295 Score = 32.3 bits (72), Expect = 0.67, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 21/36 (58%) Query: 480 GYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQ 515 GY H+DL +NILI+S ++DF S DP+ Sbjct: 144 GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPE 179 >4QTB-A nrPDB Length = 380 Score = 32.3 bits (72), Expect = 0.71, Method: Compositional matrix adjust. Identities = 51/214 (23%), Positives = 87/214 (40%), Gaps = 36/214 (16%) Query: 386 KQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACL 445 K VA+K SP + + C ++ RE L+ F H + + L TLEA Sbjct: 66 KTRVAIKKI---SP-FEHQTYCQRTLREIQILLRF----RHENVIGIRDILRASTLEAMR 117 Query: 446 DVHRGEDV-----------ENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILID 494 DV+ +D+ + ++ L I + ++ +H S H+DL+P N+LI+ Sbjct: 118 DVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIH-SANVLHRDLKPSNLLIN 176 Query: 495 SKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLS 554 + + DF + DP+ + G L YV + + + N + S Sbjct: 177 TTCDLKICDF--GLARIADPEH-----DHTGFLTEYVATRW---YRAPEIMLNSKGYTKS 226 Query: 555 PDEETKDLI------HRLFHPGEHVRDCLSDLLG 582 D + I +R PG+H D L+ +LG Sbjct: 227 IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 260 >3EQC-A nrPDB Length = 360 Score = 32.3 bits (72), Expect = 0.72, Method: Compositional matrix adjust. Identities = 26/105 (24%), Positives = 46/105 (43%), Gaps = 5/105 (4%) Query: 403 REVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFAR 462 RE+ L + ++V FYG+ G + +C+ E LD + ++ Sbjct: 80 RELQVLHECN-SPYIVGFYGAFYSDGEISICM---EHMDGGSLD-QVLKKAGRIPEQILG 134 Query: 463 NVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 V ++ K + L H+D++P NIL++S+ L DF S Sbjct: 135 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS 179 >4P5Q-A nrPDB Length = 361 Score = 32.3 bits (72), Expect = 0.73, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 21/36 (58%) Query: 480 GYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQ 515 GY H+DL +NILI+S ++DF S DP+ Sbjct: 155 GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPE 190 >3D2K-A nrPDB Length = 272 Score = 32.3 bits (72), Expect = 0.74, Method: Compositional matrix adjust. Identities = 36/130 (27%), Positives = 51/130 (39%), Gaps = 28/130 (21%) Query: 483 HQDLQPQNILIDSKKAAHLADFDKSIKWAGD------------PQEV--------KRDLE 522 H+D++P+N+L+ S +ADF S+ P E+ K DL Sbjct: 135 HRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLW 194 Query: 523 DLGRLVLYVVKKGSISFEDLKAQSNEEVVQ----LSPD---EETKDLIHRLFHPGEHVRD 575 LG L Y G FE Q + PD E +DLI RL R Sbjct: 195 SLGVLC-YEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNASQRL 253 Query: 576 CLSDLLGHPF 585 L+++L HP+ Sbjct: 254 TLAEVLEHPW 263 >4QHB-A nrPDB Length = 395 Score = 32.3 bits (72), Expect = 0.74, Method: Compositional matrix adjust. Identities = 19/105 (18%), Positives = 47/105 (44%), Gaps = 6/105 (5%) Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYV---VK 533 GY D + L ++ ++ ++KS+ W D ++ LE + +Y+ Sbjct: 138 FGVGYYSSD---NDSLSSKRRPVYIPKWEKSVTWVQDITDLYPALEREAYVGIYIDTWTA 194 Query: 534 KGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLS 578 +G ++ +L + ++ + P+ K L++ +++ G+ D S Sbjct: 195 EGYVASMELDVKESKITCDVMPERRVKPLMNTVYYIGQTYPDIFS 239 >4L11-A nrPDB Length = 204 Score = 32.3 bits (72), Expect = 0.76, Method: Compositional matrix adjust. Identities = 25/96 (26%), Positives = 43/96 (44%), Gaps = 13/96 (13%) Query: 130 MEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLK--IL 187 EAA G ++AL +K + KG + +G +E+LK ++ Sbjct: 80 FEAASPGCLRALSLKFKT-------THAPPGDILVHKGDVLTYLYFIARGSIEILKDDVV 132 Query: 188 LDEMGADVNACDNMGRNALIHALLSSDDSDVEAITH 223 + +G D D G N IH+ L +S+V+A+T+ Sbjct: 133 MAILGKD----DIFGENPCIHSTLGKSNSNVKALTY 164 >2PMN-X nrPDB Length = 348 Score = 32.3 bits (72), Expect = 0.77, Method: Compositional matrix adjust. Identities = 13/44 (29%), Positives = 24/44 (54%) Query: 464 VLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 ++ S+ + +H H+D++P NIL+D L+DF +S Sbjct: 156 IIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGES 199 >2BDW-A nrPDB Length = 362 Score = 32.3 bits (72), Expect = 0.78, Method: Compositional matrix adjust. Identities = 29/105 (27%), Positives = 47/105 (44%), Gaps = 26/105 (24%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK---KAAHLADFDKSIK------WA 511 A + + I +++ H S G H++L+P+N+L+ SK A LADF +I+ W Sbjct: 130 ASHCIQQILESIAYCH-SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWH 188 Query: 512 G---------------DPQEVKRDLEDLGRLVLYVVKKGSISFED 541 G DP D+ G ++LY++ G F D Sbjct: 189 GFAGTPGYLSPEVLKKDPYSKPVDIWACG-VILYILLVGYPPFWD 232 >3KK8-A nrPDB Length = 284 Score = 32.3 bits (72), Expect = 0.80, Method: Compositional matrix adjust. Identities = 29/105 (27%), Positives = 47/105 (44%), Gaps = 26/105 (24%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK---KAAHLADFDKSIK------WA 511 A + + I +++ H S G H++L+P+N+L+ SK A LADF +I+ W Sbjct: 107 ASHCIQQILESIAYCH-SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWH 165 Query: 512 G---------------DPQEVKRDLEDLGRLVLYVVKKGSISFED 541 G DP D+ G ++LY++ G F D Sbjct: 166 GFAGTPGYLSPEVLKKDPYSKPVDIWACG-VILYILLVGYPPFWD 209 >5KKR-C nrPDB Length = 395 Score = 32.3 bits (72), Expect = 0.80, Method: Compositional matrix adjust. Identities = 27/109 (24%), Positives = 46/109 (42%), Gaps = 13/109 (11%) Query: 403 REVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFAR 462 RE+ L + ++V FYG+ G + +C+ E LD V + Sbjct: 115 RELQVLHECN-SPYIVGFYGAFYSDGEISICM---EHMDGGSLD-----QVLKKAGRIPE 165 Query: 463 NVLS----SIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 +L ++ K + L H+D++P NIL++S+ L DF S Sbjct: 166 QILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS 214 >3BBT-B nrPDB Length = 328 Score = 32.3 bits (72), Expect = 0.80, Method: Compositional matrix adjust. Identities = 39/159 (24%), Positives = 63/159 (39%), Gaps = 25/159 (15%) Query: 377 GGIYLGFYE------KQEVAVKTFCEGS-PRAQREV---SCLQSSRENSHLVTFYGSESH 426 G +Y G + K VA+K E + P+A E + + +S ++ HLV G Sbjct: 29 GTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLG---- 84 Query: 427 RGHLFVCVTLCEQTL-----EACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 VC++ Q + CL + E +N + N I K + L Sbjct: 85 -----VCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLE-ERRL 138 Query: 482 THQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRD 520 H+DL +N+L+ S + DF + GD +E D Sbjct: 139 VHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNAD 177 >3H4J-B nrPDB Length = 336 Score = 32.3 bits (72), Expect = 0.82, Method: Compositional matrix adjust. Identities = 27/108 (25%), Positives = 48/108 (44%), Gaps = 7/108 (6%) Query: 400 RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDE 459 R +RE+S L+ R + H++ Y + + + + L + V + E+E Sbjct: 55 RVEREISYLKLLR-HPHIIKLYDVITTPTDIVMVIEYAGGELFDYI-VEKKRMTEDE--- 109 Query: 460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 R I A++ H H+DL+P+N+L+D +ADF S Sbjct: 110 -GRRFFQQIICAIEYCH-RHKIVHRDLKPENLLLDDNLNVKIADFGLS 155 >6CMJ-A nrPDB Length = 321 Score = 32.3 bits (72), Expect = 0.84, Method: Compositional matrix adjust. Identities = 38/167 (22%), Positives = 64/167 (38%), Gaps = 40/167 (23%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD------- 513 AR + K ++ LH H+D++P N+L+ +ADF S ++ G Sbjct: 145 ARFYFQDLIKGIEYLHYQ-KIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNT 203 Query: 514 --------PQEVKR----------DLEDLGRLVLYVVKKGSISFED---------LKAQS 546 P+ + D+ +G + LY G F D +K+Q+ Sbjct: 204 VGTPAFMAPESLSETRKIFSGKALDVWAMG-VTLYCFVFGQCPFMDERIMCLHSKIKSQA 262 Query: 547 NEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRY 593 E Q E+ KDLI R+ R + ++ HP W +R+ Sbjct: 263 LEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHP----WVTRH 305 >3A4O-X nrPDB Length = 286 Score = 32.3 bits (72), Expect = 0.85, Method: Compositional matrix adjust. Identities = 40/196 (20%), Positives = 74/196 (37%), Gaps = 43/196 (21%) Query: 377 GGIYLGFYEKQ-EVAVKTFCEGSPRAQR--EVSCLQSSRENSHLVTFYGSESHRGHLFVC 433 G +++G+Y +VAVKT G+ Q E + L + ++ LV Y + +++ Sbjct: 27 GEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYII 86 Query: 434 VTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYT------HQDLQ 487 + + LD + DE + +L + ++ Y H+DL+ Sbjct: 87 TEYMAKG--SLLDFLKS-------DEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLR 137 Query: 488 PQNILIDSKKAAHLADFDKS-----------------IKWAGDPQ-------EVKRDLED 523 N+L+ +ADF + IKW P+ +K D+ Sbjct: 138 AANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTA-PEAINFGCFTIKSDVWS 196 Query: 524 LGRLVLYVVKKGSISF 539 G L+ +V G I + Sbjct: 197 FGILLYEIVTYGKIPY 212 >5AIR-A nrPDB Length = 430 Score = 32.3 bits (72), Expect = 0.86, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 28/46 (60%), Gaps = 2/46 (4%) Query: 460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAA-HLADF 504 + + + +F+++ +H S G H+D++PQN+L+D A L DF Sbjct: 167 YVKLYMYQLFRSLAYIH-SFGICHRDIKPQNLLLDPDTAVLKLCDF 211 >4RED-A nrPDB Length = 351 Score = 32.3 bits (72), Expect = 0.87, Method: Compositional matrix adjust. Identities = 16/47 (34%), Positives = 25/47 (53%), Gaps = 1/47 (2%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 +R + I V H H+DL+P+N+L+D+ A +ADF S Sbjct: 116 SRRLFQQILSGVDYCHRHM-VVHRDLKPENVLLDAHMNAKIADFGLS 161 >5YV8-A nrPDB Length = 298 Score = 32.0 bits (71), Expect = 0.89, Method: Compositional matrix adjust. Identities = 40/170 (23%), Positives = 66/170 (38%), Gaps = 41/170 (24%) Query: 457 EDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD--- 513 ED+ AR + K ++ LH H+D++P N+L+ +ADF S ++ G Sbjct: 136 EDQ-ARFYFQDLIKGIEYLHYQ-KIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDAL 193 Query: 514 ------------PQEVKR----------DLEDLGRLVLYVVKKGSISFED---------L 542 P+ + D+ +G + LY G F D + Sbjct: 194 LSNTVGTPAFMAPESLSETRKIFSGKALDVWAMG-VTLYCFVFGQCPFMDERIMCLHSKI 252 Query: 543 KAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESR 592 K+Q+ E Q E+ KDLI R+ R + ++ HP W +R Sbjct: 253 KSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHP----WVTR 298 >4CFH-A nrPDB Length = 493 Score = 32.0 bits (71), Expect = 0.95, Method: Compositional matrix adjust. Identities = 15/44 (34%), Positives = 24/44 (54%), Gaps = 1/44 (2%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 +R + I V H H+DL+P+N+L+D+ A +ADF Sbjct: 135 SRRLFQQILSGVDYCHRHM-VVHRDLKPENVLLDAHMNAKIADF 177 >3ATG-A nrPDB Length = 256 Score = 32.0 bits (71), Expect = 0.95, Method: Compositional matrix adjust. Identities = 17/58 (29%), Positives = 28/58 (48%), Gaps = 1/58 (1%) Query: 327 EDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEK-YKIADTSEGGIYLGF 383 + FH A DWKP W + HR+ R +G + D+ + I + + GG + G+ Sbjct: 162 DTFHTFAVDWKPGEITWFVDGQQFHRVTRASVGANAWVFDQPFFLILNVAVGGQWPGY 219 >4PDS-A nrPDB Length = 347 Score = 32.0 bits (71), Expect = 0.96, Method: Compositional matrix adjust. Identities = 14/34 (41%), Positives = 22/34 (64%), Gaps = 1/34 (2%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILID 494 R + I A++ +H S G +H+DL+P NILI+ Sbjct: 131 GREISRQILTAIKYIH-SMGISHRDLKPDNILIE 163 >5XZW-A nrPDB Length = 471 Score = 32.0 bits (71), Expect = 0.97, Method: Compositional matrix adjust. Identities = 17/49 (34%), Positives = 27/49 (55%), Gaps = 3/49 (6%) Query: 458 DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILI--DSKKAAHLADF 504 ++ R + I A++ +H S G +H+DL+P NILI D + DF Sbjct: 293 EDAGREISRQILTAIKYIH-SMGISHRDLKPDNILIEQDDPVLVKITDF 340 >4REW-A nrPDB Length = 540 Score = 32.0 bits (71), Expect = 1.0, Method: Compositional matrix adjust. Identities = 15/44 (34%), Positives = 24/44 (54%), Gaps = 1/44 (2%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 +R + I V H H+DL+P+N+L+D+ A +ADF Sbjct: 108 SRRLFQQILSGVDYCHRHM-VVHRDLKPENVLLDAHMNAKIADF 150 >2NYJ-A nrPDB Length = 273 Score = 32.0 bits (71), Expect = 1.1, Method: Compositional matrix adjust. Identities = 43/156 (27%), Positives = 62/156 (39%), Gaps = 29/156 (18%) Query: 59 GWTPLHNAVQMSREDIVELLLRHGAD-------PVLRKKN-------GATPFILAAIAGS 104 G T LH A++ +V LL+ +GAD +K G P LAA Sbjct: 101 GQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQ 160 Query: 105 VKLLKLFLSKG---ADVNECDFYGFT---AFMEAA--VYGKVKALKFLYKR----GANVN 152 + ++K L AD++ D G T A +E A K + +Y GA ++ Sbjct: 161 LAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLH 220 Query: 153 LRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188 K +E R G T L AA G + VL +L Sbjct: 221 PTLKLEEITNR---KGLTPLALAASSGKIGVLAYIL 253 >4LQP-A nrPDB Length = 508 Score = 31.6 bits (70), Expect = 1.2, Method: Compositional matrix adjust. Identities = 14/47 (29%), Positives = 27/47 (57%), Gaps = 1/47 (2%) Query: 458 DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 ++ R ++ A++ +H G+ H+ ++P NILID + L+DF Sbjct: 201 EDVTRFYMAECILAIETIH-KLGFIHRAIKPDNILIDIRGHIKLSDF 246 >4IAN-A nrPDB Length = 358 Score = 31.6 bits (70), Expect = 1.2, Method: Compositional matrix adjust. Identities = 40/167 (23%), Positives = 69/167 (41%), Gaps = 22/167 (13%) Query: 354 YRPMIGKLKFFIDEKYKIADTSEGGIYLGFYE-------KQEVAVKTFCEGSPRAQ---R 403 YR IG++ +D++Y + + G++ QEVAVK + + Sbjct: 20 YRVNIGEV---LDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLK 76 Query: 404 EVSCLQSSRENS-----HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEED 458 E+ L+ + H + + H+ HL + L L + G+DV Sbjct: 77 ELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKY-GKDV-GLHI 134 Query: 459 EFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILID-SKKAAHLADF 504 + R+ +F A++ L C H D++P NIL++ SK L DF Sbjct: 135 KAVRSYSQQLFLALKLLK-RCNILHADIKPDNILVNESKTILKLCDF 180 >3HDN-A nrPDB Length = 373 Score = 31.6 bits (70), Expect = 1.3, Method: Compositional matrix adjust. Identities = 18/44 (40%), Positives = 26/44 (59%), Gaps = 1/44 (2%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 AR + I A+ LH S ++DL+P+NIL+DS+ L DF Sbjct: 141 ARFYAAEIASALGYLH-SLNIVYRDLKPENILLDSQGHIVLTDF 183 >4M66-A nrPDB Length = 325 Score = 31.6 bits (70), Expect = 1.3, Method: Compositional matrix adjust. Identities = 14/25 (56%), Positives = 18/25 (72%) Query: 483 HQDLQPQNILIDSKKAAHLADFDKS 507 H+DL+P NIL+D + A LADF S Sbjct: 141 HRDLKPSNILLDPELHAKLADFGLS 165 >5AR8-A nrPDB Length = 326 Score = 31.6 bits (70), Expect = 1.3, Method: Compositional matrix adjust. Identities = 21/65 (32%), Positives = 32/65 (49%), Gaps = 2/65 (3%) Query: 447 VHRGEDVENEEDEFARNVLSSIFKAVQELH-LSCGYTHQDLQPQNILIDSKKAAHLADFD 505 +HR + + +L I V LH ++ H DL+ QNIL+D++ +ADF Sbjct: 123 LHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFG 182 Query: 506 KSIKW 510 S KW Sbjct: 183 LS-KW 186 >4AGU-A nrPDB Length = 311 Score = 31.6 bits (70), Expect = 1.3, Method: Compositional matrix adjust. Identities = 39/151 (25%), Positives = 63/151 (41%), Gaps = 20/151 (13%) Query: 367 EKY-KIADTSEGGIYLGFYEK-----QEVAVKTFCEG------SPRAQREVSCLQSSREN 414 EKY KI EG + F + Q VA+K F E A RE+ L+ + + Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLK-H 61 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 +LV + L + C+ T+ LD ++ + +++ +AV Sbjct: 62 PNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQ----RGVPEHLVKSITWQTLQAVNF 117 Query: 475 LHL-SCGYTHQDLQPQNILIDSKKAAHLADF 504 H +C H+D++P+NILI L DF Sbjct: 118 CHKHNC--IHRDVKPENILITKHSVIKLCDF 146 >3NCG-A nrPDB Length = 486 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 38/174 (21%), Positives = 75/174 (43%), Gaps = 38/174 (21%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA---AHLADFDKSIKWAGDPQ-- 515 A ++ +F + +H H+DL+P+NIL++SK+ + DF S + + + Sbjct: 123 AARIIKQVFSGITYMH-KHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMK 181 Query: 516 -----------EVKRDLED------LGRLVLYVVKKGSISF-----EDL--KAQSNEEVV 551 EV R D ++LY++ G+ F D+ + ++ + Sbjct: 182 DRIGTAYYIAPEVLRGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAF 241 Query: 552 QL----SPDEETKDLIHRL--FHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNV 599 L + ++ KDLI ++ FHP +R + L HP+ + S T+ ++ Sbjct: 242 DLPQWRTISDDAKDLIRKMLTFHPS--LRITATQCLEHPWIQKYSSETPTISDL 293 >2H34-A nrPDB Length = 309 Score = 31.2 bits (69), Expect = 1.5, Method: Compositional matrix adjust. Identities = 11/23 (47%), Positives = 18/23 (78%) Query: 482 THQDLQPQNILIDSKKAAHLADF 504 TH+D++P+NIL+ + A+L DF Sbjct: 156 THRDVKPENILVSADDFAYLVDF 178 >6FD3-A nrPDB Length = 300 Score = 31.2 bits (69), Expect = 1.5, Method: Compositional matrix adjust. Identities = 37/146 (25%), Positives = 62/146 (42%), Gaps = 23/146 (15%) Query: 370 KIADTSEGGIY--LGFYEKQEVAVKTF-CEGSPRAQREVSCLQSSREN--SHLVTFYGSE 424 KI + G +Y L QEVA+K + P+ + ++ + REN ++V + S Sbjct: 29 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 88 Query: 425 SHRGHLFVCV------TLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLS 478 L+V + +L + E C+D E + A V +A+ LH S Sbjct: 89 LVGDELWVVMEYLAGGSLTDVVTETCMD----------EGQIAA-VCRECLQALDFLH-S 136 Query: 479 CGYTHQDLQPQNILIDSKKAAHLADF 504 H+D++ NIL+ + L DF Sbjct: 137 NQVIHRDIKSDNILLGMDGSVKLTDF 162 >2DQ7-X nrPDB Length = 283 Score = 31.2 bits (69), Expect = 1.7, Method: Compositional matrix adjust. Identities = 45/212 (21%), Positives = 89/212 (41%), Gaps = 39/212 (18%) Query: 370 KIADTSEGGIYLGFYE-KQEVAVKTFCEG--SPRAQREVSCLQSSRENSHLVTFYGSESH 426 ++ + G +++G + +VA+KT G SP + E + + ++ LV Y S Sbjct: 16 RLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSE 75 Query: 427 RGHLFVCVTLCEQTLEACLDVHRGEDVE--NEEDEFARNVLSSIFKAVQELHLSCGYTHQ 484 V + + +L L G ++ N D A+ +++ ++ ++ Y H+ Sbjct: 76 EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQ--VAAGMAYIERMN----YIHR 129 Query: 485 DLQPQNILIDSKKAAHLADFDKS-----------------IKWAGDPQ-------EVKRD 520 DL+ NIL+ + +ADF + IKW P+ +K D Sbjct: 130 DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTA-PEAALYGRFTIKSD 188 Query: 521 LEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQ 552 + G L+ +V KG + + + +N EV++ Sbjct: 189 VWSFGILLTELVTKGRVPYPGM---NNREVLE 217 >5AWM-A nrPDB Length = 394 Score = 31.2 bits (69), Expect = 1.7, Method: Compositional matrix adjust. Identities = 40/181 (22%), Positives = 78/181 (43%), Gaps = 20/181 (11%) Query: 338 PQSSHWGAALKDLHRIYRPMIGKLKFFIDEKY---KIADTSEGGIYLGFYE---KQEVAV 391 P+ SH H+ Y +G F I +Y + + GI Y+ +Q VA+ Sbjct: 16 PRGSHRTMTTAQ-HQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAI 74 Query: 392 KTFCEG------SPRAQREVSCLQSSRENSHLVTFYGSESHRGHL--FVCVTLCEQTLEA 443 K + RA RE ++ + +++ + + + +L F V L + ++A Sbjct: 75 KKLSRPFQNVTHAKRAYREFKLMKLV-NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA 133 Query: 444 CLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLAD 503 L D++++ + +L + ++ LH S G H+DL+P NI++ + + D Sbjct: 134 NLCQVIQMDLDHDRMSY---LLYQMLCGIKHLH-SAGIIHRDLKPSNIVVKADCTLKILD 189 Query: 504 F 504 F Sbjct: 190 F 190 >4BGQ-A nrPDB Length = 304 Score = 31.2 bits (69), Expect = 1.8, Method: Compositional matrix adjust. Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 12/122 (9%) Query: 389 VAVKTFCEGSPRAQ------REVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLE 442 VA+K F + + RE+ L++ ++ ++V + RG L++ E+ + Sbjct: 40 VAIKKFKDSEENEEVKETTLRELKMLRTLKQ-ENIVELKEAFRRRGKLYLVFEYVEKNML 98 Query: 443 ACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLA 502 L+ E E ++ + + KA+ H + H+D++P+N+LI L Sbjct: 99 ELLE----EMPNGVPPEKVKSYIYQLIKAIHWCHKN-DIVHRDIKPENLLISHNDVLKLC 153 Query: 503 DF 504 DF Sbjct: 154 DF 155 >5G6V-A nrPDB Length = 324 Score = 30.8 bits (68), Expect = 2.1, Method: Compositional matrix adjust. Identities = 34/113 (30%), Positives = 56/113 (49%), Gaps = 13/113 (11%) Query: 396 EGSP-RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVE 454 EG+P A REVS L+ + ++++VT + L + ++ L+ LD D Sbjct: 41 EGAPCTAIREVSLLKDLK-HANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLD-----DCG 94 Query: 455 NEEDEFARNVLSSIFKAVQELHLSC---GYTHQDLQPQNILIDSKKAAHLADF 504 N + NV +F+ ++ L C H+DL+PQN+LI+ + LADF Sbjct: 95 NIIN--MHNVKLFLFQLLRGLAY-CHRQKVLHRDLKPQNLLINERGELKLADF 144 >2JD5-A nrPDB Length = 373 Score = 30.8 bits (68), Expect = 2.1, Method: Compositional matrix adjust. Identities = 23/110 (20%), Positives = 51/110 (46%), Gaps = 21/110 (19%) Query: 401 AQREVSCLQ------SSRENS----HLVTFYGSESHRG----HLFVCVTLCEQTLEACLD 446 A+ E+ LQ +++E+S H++ +H+G H+ + + + L A + Sbjct: 62 AEDEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIK 121 Query: 447 V--HRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILID 494 HRG + + + + + + +H CG H D++P+N+L++ Sbjct: 122 KYEHRGIPLI-----YVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLME 166 >5JZN-A nrPDB Length = 280 Score = 30.8 bits (68), Expect = 2.3, Method: Compositional matrix adjust. Identities = 16/48 (33%), Positives = 28/48 (58%), Gaps = 5/48 (10%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILI----DSKKAAHLADF 504 A +L ++ A++ LH S H+D++P+N+L+ D K+ L DF Sbjct: 119 ASGMLYNLASAIKYLH-SLNIVHRDIKPENLLVYEHQDGSKSLKLGDF 165 >4U41-A nrPDB Length = 332 Score = 30.8 bits (68), Expect = 2.3, Method: Compositional matrix adjust. Identities = 23/110 (20%), Positives = 51/110 (46%), Gaps = 9/110 (8%) Query: 404 EVSCLQSSRENSHLVTFYGS---ESHRGH---LFVCVTLCEQTLEACLDVHRGEDVENEE 457 E++ L+ + ++ T+YG+ +S GH L++ + C + D+ + + Sbjct: 70 EINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAG--SITDLVKNTKGNTLK 127 Query: 458 DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 +++ + I + + LH+ H+D++ QN+L+ L DF S Sbjct: 128 EDWIAYISREILRGLAHLHIH-HVIHRDIKGQNVLLTENAEVKLVDFGVS 176 >6MHW-A nrPDB Length = 826 Score = 30.4 bits (67), Expect = 2.6, Method: Compositional matrix adjust. Identities = 16/39 (41%), Positives = 20/39 (51%) Query: 239 GKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTAL 277 G+TPL LA +VQ L+E E +I DS G L Sbjct: 263 GETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNIL 301 >3FI2-A nrPDB Length = 353 Score = 30.4 bits (67), Expect = 2.7, Method: Compositional matrix adjust. Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 2/61 (3%) Query: 445 LDVHRGEDVENEED-EFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLAD 503 +D + + ++ E D E +L + ++ LH S G H+DL+P NI++ S + D Sbjct: 111 MDANLCQVIQMELDHERMSYLLYQMLCGIKHLH-SAGIIHRDLKPSNIVVKSDCTLKILD 169 Query: 504 F 504 F Sbjct: 170 F 170 >4WUA-A nrPDB Length = 401 Score = 30.4 bits (67), Expect = 2.8, Method: Compositional matrix adjust. Identities = 9/33 (27%), Positives = 19/33 (57%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILI 493 + ++ + + + LH C H D++P+NIL+ Sbjct: 152 VKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL 184 >3ORZ-A nrPDB Length = 316 Score = 30.4 bits (67), Expect = 2.9, Method: Compositional matrix adjust. Identities = 15/44 (34%), Positives = 24/44 (54%), Gaps = 1/44 (2%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 R + I A++ LH G H+DL+P+NIL++ + DF Sbjct: 139 TRFYTAEIVSALEYLH-GKGIIHRDLKPENILLNEDMHIQITDF 181 >2XS0-A nrPDB Length = 386 Score = 30.4 bits (67), Expect = 3.1, Method: Compositional matrix adjust. Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 2/61 (3%) Query: 445 LDVHRGEDVENEED-EFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLAD 503 +D + + ++ E D E +L + ++ LH S G H+DL+P NI++ S + D Sbjct: 113 MDANLCQVIQMELDHERMSYLLYQMLCGIKHLH-SAGIIHRDLKPSNIVVKSDCTLKILD 171 Query: 504 F 504 F Sbjct: 172 F 172 >2Y6O-A nrPDB Length = 291 Score = 30.4 bits (67), Expect = 3.2, Method: Compositional matrix adjust. Identities = 13/35 (37%), Positives = 20/35 (57%) Query: 481 YTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQ 515 Y H+DL +NIL++S ++DF S DP+ Sbjct: 137 YVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPE 171 >4KS7-A nrPDB Length = 292 Score = 30.0 bits (66), Expect = 3.3, Method: Compositional matrix adjust. Identities = 55/265 (20%), Positives = 104/265 (39%), Gaps = 44/265 (16%) Query: 359 GKLKFFIDEKYKIADTSEGGIYLGF--YEKQEVAVKTFCEGSPRAQREV----SCLQSSR 412 G + +D KI + S G + L + ++VAVK + + +RE+ + Sbjct: 19 GDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMM-DLRKQQRRELLFNEVVIMRDY 77 Query: 413 ENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAV 472 ++ ++V Y S L+V + + A D+ V E++ A V ++ +A+ Sbjct: 78 QHFNVVEMYKSYLVGEELWVLMEFLQGG--ALTDI--VSQVRLNEEQIA-TVCEAVLQAL 132 Query: 473 QELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD---------------PQEV 517 LH + G H+D++ +IL+ L+DF + + D P+ + Sbjct: 133 AYLH-AQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI 191 Query: 518 KR-------DLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDE---------ETKD 561 R D+ LG +V+ +V F D Q+ + + P + +D Sbjct: 192 SRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRD 251 Query: 562 LIHRLFHPGEHVRDCLSDLLGHPFF 586 + R+ R +LL HPF Sbjct: 252 FLERMLVRDPQERATAQELLDHPFL 276 >1JNK-A nrPDB Length = 423 Score = 30.0 bits (66), Expect = 3.3, Method: Compositional matrix adjust. Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 2/61 (3%) Query: 445 LDVHRGEDVENEED-EFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLAD 503 +D + + ++ E D E +L + ++ LH S G H+DL+P NI++ S + D Sbjct: 149 MDANLCQVIQMELDHERMSYLLYQMLCGIKHLH-SAGIIHRDLKPSNIVVKSDCTLKILD 207 Query: 504 F 504 F Sbjct: 208 F 208 >2X7G-A nrPDB Length = 389 Score = 30.0 bits (66), Expect = 3.5, Method: Compositional matrix adjust. Identities = 9/33 (27%), Positives = 20/33 (60%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILI 493 ++++ + + + LH C H D++P+NIL+ Sbjct: 142 VKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM 174 >6HXF-B nrPDB Length = 302 Score = 30.0 bits (66), Expect = 3.6, Method: Compositional matrix adjust. Identities = 26/99 (26%), Positives = 48/99 (48%), Gaps = 8/99 (8%) Query: 413 ENSHLVTFYGSESHRGHLFVCVTLCEQ-TLEAC-LDVHRGEDVENEEDEFARNVLSSIFK 470 ++ ++V G+ H G L++ + C ++A L++ RG + + V + + Sbjct: 74 DHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLT-----EPQIQVVCRQMLE 128 Query: 471 AVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK 509 A+ LH S H+DL+ N+L+ + LADF S K Sbjct: 129 ALNFLH-SKRIIHRDLKAGNVLMTLEGDIRLADFGVSAK 166 >5D7A-A nrPDB Length = 308 Score = 30.0 bits (66), Expect = 3.6, Method: Compositional matrix adjust. Identities = 28/148 (18%), Positives = 63/148 (42%), Gaps = 14/148 (9%) Query: 371 IADTSEGGIYLGFYEK--QEVAVKTF---CEGSPRAQREVSCLQSSRENSHLVTFYGSES 425 + + + G +Y G + K Q A+K + ++E++ L+ + ++ T+YG+ Sbjct: 25 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFI 84 Query: 426 HRG------HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSC 479 + L++ + C + D+ + ++E+ + I + + LH Sbjct: 85 KKNPPGMDDQLWLVMEFCGAG--SVTDLIKNTKGNTLKEEWIAYICREILRGLSHLH-QH 141 Query: 480 GYTHQDLQPQNILIDSKKAAHLADFDKS 507 H+D++ QN+L+ L DF S Sbjct: 142 KVIHRDIKGQNVLLTENAEVKLVDFGVS 169 >4FR4-A nrPDB Length = 384 Score = 30.0 bits (66), Expect = 3.8, Method: Compositional matrix adjust. Identities = 25/93 (26%), Positives = 43/93 (46%), Gaps = 5/93 (5%) Query: 413 ENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAV 472 E+ LV + S +F+ V L L L H ++V +E E + + + A+ Sbjct: 73 EHPFLVNLWYSFQDEEDMFMVVDLL---LGGDLRYHLQQNVHFKE-ETVKLFICELVMAL 128 Query: 473 QELHLSCGYTHQDLQPQNILIDSKKAAHLADFD 505 L + H+D++P NIL+D H+ DF+ Sbjct: 129 DYLQ-NQRIIHRDMKPDNILLDEHGHVHITDFN 160 >3DFA-A nrPDB Length = 286 Score = 30.0 bits (66), Expect = 3.9, Method: Compositional matrix adjust. Identities = 37/166 (22%), Positives = 71/166 (42%), Gaps = 38/166 (22%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA---AHLADFDKSIKWAGDPQ-- 515 A ++ +F + +H H+DL+P+NIL++SK+ + DF S + + + Sbjct: 123 AARIIKQVFSGITYMH-KHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMK 181 Query: 516 -----------EVKRDLED------LGRLVLYVVKKGSISF-----EDL--KAQSNEEVV 551 EV R D ++LY++ G+ F D+ + ++ + Sbjct: 182 DRIGTAYYIAPEVLRGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAF 241 Query: 552 QL----SPDEETKDLIHRL--FHPGEHVRDCLSDLLGHPFFWTWES 591 L + ++ KDLI ++ FHP +R + L HP+ + S Sbjct: 242 DLPQWRTISDDAKDLIRKMLTFHPS--LRITATQCLEHPWIQKYSS 285 >3Q5I-A nrPDB Length = 504 Score = 30.0 bits (66), Expect = 3.9, Method: Compositional matrix adjust. Identities = 23/115 (20%), Positives = 56/115 (48%), Gaps = 13/115 (11%) Query: 404 EVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCE--QTLEACLDVHRGEDVENEEDEFA 461 E+S L+S ++ +++ + + + ++ E + E ++ H+ ++ + A Sbjct: 96 EISLLKS-LDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECD------A 148 Query: 462 RNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA---AHLADFDKSIKWAGD 513 N++ I + LH H+D++P+NIL+++K + + DF S ++ D Sbjct: 149 ANIMKQILSGICYLH-KHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKD 202 >3UTO-A nrPDB Length = 573 Score = 30.0 bits (66), Expect = 4.0, Method: Compositional matrix adjust. Identities = 19/63 (30%), Positives = 33/63 (52%), Gaps = 5/63 (7%) Query: 454 ENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD 513 E+E E+ R V K + +H + Y H DL+P+NI+ +K++ L D + D Sbjct: 254 EDEAVEYMRQVC----KGLCHMHEN-NYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLD 308 Query: 514 PQE 516 P++ Sbjct: 309 PKQ 311 >1KOA-A nrPDB Length = 491 Score = 30.0 bits (66), Expect = 4.0, Method: Compositional matrix adjust. Identities = 19/63 (30%), Positives = 32/63 (50%), Gaps = 5/63 (7%) Query: 454 ENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD 513 E+E E+ R V K + +H Y H DL+P+NI+ +K++ L D + D Sbjct: 148 EDEAVEYMRQVC----KGLCHMH-ENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLD 202 Query: 514 PQE 516 P++ Sbjct: 203 PKQ 205 >2QNJ-A nrPDB Length = 328 Score = 30.0 bits (66), Expect = 4.1, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 24/44 (54%), Gaps = 1/44 (2%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 AR+ I AVQ H H+DL+ +N+L+D+ +ADF Sbjct: 113 ARSKFRQIVSAVQYCH-QKRIVHRDLKAENLLLDADMNIKIADF 155 >6IRA-D nrPDB Length = 853 Score = 30.0 bits (66), Expect = 4.2, Method: Compositional matrix adjust. Identities = 22/71 (30%), Positives = 34/71 (47%), Gaps = 6/71 (8%) Query: 181 VEVLKILL---DEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLL--LDHGADVNVR 235 V V+ +L+ D + CD M A IH L+ DD+D EA+ +L + V + Sbjct: 67 VNVVALLMNRTDPKSLITHVCDLMS-GARIHGLVFGDDTDQEAVAQMLDFISSHTFVPIL 125 Query: 236 GERGKTPLILA 246 G G +I+A Sbjct: 126 GIHGGASMIMA 136 >3GC9-A nrPDB Length = 370 Score = 29.6 bits (65), Expect = 4.4, Method: Compositional matrix adjust. Identities = 12/47 (25%), Positives = 26/47 (55%), Gaps = 1/47 (2%) Query: 458 DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 DE + ++ + + ++ +H S G H+DL+P N+ ++ + DF Sbjct: 130 DEHVQFLVYQLLRGLKYIH-SAGIIHRDLKPSNVAVNEDSELRILDF 175 >5X8I-B nrPDB Length = 346 Score = 29.6 bits (65), Expect = 4.5, Method: Compositional matrix adjust. Identities = 47/190 (24%), Positives = 77/190 (40%), Gaps = 26/190 (13%) Query: 365 IDEKYKIADTSEGGIYLGFYE-------KQEVAVKT------FCEGSPRAQREVSCLQSS 411 + +Y+I DT G + E + VAVK +CE + + + L ++ Sbjct: 11 LSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTT 70 Query: 412 RENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 471 NS E H +C+ E + D + + R + I K+ Sbjct: 71 DPNSTFRCVQMLEWFEHHGHICIVF-ELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKS 129 Query: 472 VQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYV 531 V LH S TH DL+P+NIL +D+ + A +P+ +KRD L + V Sbjct: 130 VNFLH-SNKLTHTDLKPENILFVQ------SDYTE----AYNPK-IKRDERTLINPDIKV 177 Query: 532 VKKGSISFED 541 V GS +++D Sbjct: 178 VDFGSATYDD 187 >3E7O-A nrPDB Length = 360 Score = 29.6 bits (65), Expect = 4.6, Method: Compositional matrix adjust. Identities = 14/41 (34%), Positives = 23/41 (56%), Gaps = 1/41 (2%) Query: 464 VLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 504 +L + ++ LH S G H+DL+P NI++ S + DF Sbjct: 129 LLYQMLCGIKHLH-SAGIIHRDLKPSNIVVKSDCTLKILDF 168 >4WJ3-A nrPDB Length = 484 Score = 29.6 bits (65), Expect = 4.9, Method: Compositional matrix adjust. Identities = 24/80 (30%), Positives = 38/80 (47%), Gaps = 8/80 (10%) Query: 271 SDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVM-TARRNYDHSLVKVLLSHGA---- 325 ++G+ LL + K +L C +G T CG ++ YD ++V+ L + GA Sbjct: 62 ANGENGALLGAPIAHK---DLFCTQGVRTSCGSKMLDNFVSPYDATVVEKLTAAGAVTLG 118 Query: 326 KEDFHPPAEDWKPQSSHWGA 345 K + A QSSH+GA Sbjct: 119 KLNMDEFAMGSSNQSSHYGA 138 >2HW6-A nrPDB Length = 307 Score = 29.6 bits (65), Expect = 4.9, Method: Compositional matrix adjust. Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 4/48 (8%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKK---AAHLADFD 505 A V+ + A+ LH G H+DL+P+NIL +S + + DFD Sbjct: 113 ASRVVRDVAAALDFLHTK-GIAHRDLKPENILCESPEKVSPVKICDFD 159 >6CCF-A nrPDB Length = 290 Score = 29.6 bits (65), Expect = 5.3, Method: Compositional matrix adjust. Identities = 37/161 (22%), Positives = 62/161 (38%), Gaps = 34/161 (21%) Query: 458 DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV 517 +E AR L + ++ LH H+D++P N+L+ +ADF S ++ G+ ++ Sbjct: 128 EEQARLYLRDVILGLEYLHCQ-KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQL 186 Query: 518 KRD-----------LEDLGR-------------LVLYVVKKGSISFED------LKAQSN 547 + D G+ + LY G F D + N Sbjct: 187 SSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKN 246 Query: 548 EEVV---QLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPF 585 E VV + EE KDLI ++ R + D+ HP+ Sbjct: 247 EPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPW 287 >5IRX-A nrPDB Length = 636 Score = 29.6 bits (65), Expect = 5.4, Method: Compositional matrix adjust. Identities = 43/156 (27%), Positives = 62/156 (39%), Gaps = 29/156 (18%) Query: 59 GWTPLHNAVQMSREDIVELLLRHGADP-------VLRKKN-------GATPFILAAIAGS 104 G T LH A++ +V LL+ +GAD +K G P LAA Sbjct: 96 GQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQ 155 Query: 105 VKLLKLFLSKG---ADVNECDFYGFT---AFMEAA--VYGKVKALKFLYKR----GANVN 152 + ++K L AD++ D G T A +E A K + +Y GA ++ Sbjct: 156 LAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLH 215 Query: 153 LRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188 K +E R G T L AA G + VL +L Sbjct: 216 PTLKLEEITNR---KGLTPLALAASSGKIGVLAYIL 248 >4WNO-A nrPDB Length = 287 Score = 29.6 bits (65), Expect = 5.5, Method: Compositional matrix adjust. Identities = 22/64 (34%), Positives = 31/64 (48%), Gaps = 12/64 (18%) Query: 462 RNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDL 521 R L I A++ LH S G H+DL+PQNIL+ S A A +P ++ + Sbjct: 120 RLFLQQIAGAMRLLH-SKGIIHRDLKPQNILL-SNPAGRRA----------NPNSIRVKI 167 Query: 522 EDLG 525 D G Sbjct: 168 ADFG 171 >4PDO-A nrPDB Length = 299 Score = 29.3 bits (64), Expect = 5.7, Method: Compositional matrix adjust. Identities = 13/35 (37%), Positives = 20/35 (57%) Query: 481 YTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQ 515 Y H+DL +NIL++S ++DF S DP+ Sbjct: 158 YVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPE 192 >5XVU-A nrPDB Length = 332 Score = 29.3 bits (64), Expect = 5.8, Method: Compositional matrix adjust. Identities = 15/37 (40%), Positives = 22/37 (59%), Gaps = 1/37 (2%) Query: 458 DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILID 494 D+ R + I KA+ H S G H+D++P NI+ID Sbjct: 124 DKDIRYYIYQILKALDYCH-SQGIMHRDVKPHNIMID 159 >6O6Q-A nrPDB Length = 335 Score = 29.3 bits (64), Expect = 5.8, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 25/44 (56%), Gaps = 2/44 (4%) Query: 462 RNVLSSIFKAVQELHLSCGYTHQDLQPQNILID-SKKAAHLADF 504 R + + KA+ H S G H+D++P N++ID KK L D+ Sbjct: 138 RFYMYELLKALDYSH-SMGIMHRDVKPHNVMIDHDKKLLRLIDW 180 >5L6P-A nrPDB Length = 298 Score = 29.3 bits (64), Expect = 5.8, Method: Compositional matrix adjust. Identities = 16/67 (23%), Positives = 31/67 (46%) Query: 481 YTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFE 540 Y H+DL +NIL++S ++DF S DP + G++ + +I++ Sbjct: 142 YVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYR 201 Query: 541 DLKAQSN 547 + S+ Sbjct: 202 KFTSASD 208 >2A5E-A nrPDB Length = 156 Score = 29.3 bits (64), Expect = 5.9, Method: Composition-based stats. Identities = 33/103 (32%), Positives = 44/103 (42%), Gaps = 13/103 (12%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 L A V+ V+ LLE GA N G P+ + M + ELLL HGA+P Sbjct: 16 LATAAARGRVEEVRALLEAGALPN-APNSYGRRPIQ-VMMMGSARVAELLLLHGAEP--- 70 Query: 89 KKNGATPFIL------AAIAGSVKLLKLFLSKGADVNECDFYG 125 N A P L AA G + L + GA ++ D +G Sbjct: 71 --NCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWG 111 >4LFI-A nrPDB Length = 374 Score = 29.3 bits (64), Expect = 6.5, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 25/44 (56%), Gaps = 2/44 (4%) Query: 462 RNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK-KAAHLADF 504 R + + KA+ H S G H+D++P N++ID K K L D+ Sbjct: 175 RFYMFELLKALDYCH-SMGIMHRDVKPHNVMIDHKNKKLRLIDW 217 >5KZ7-A nrPDB Length = 346 Score = 29.3 bits (64), Expect = 6.6, Method: Compositional matrix adjust. Identities = 27/102 (26%), Positives = 43/102 (42%), Gaps = 24/102 (23%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF---------DKSIKWA 511 AR I AVQ H H+DL+ +N+L+D+ +ADF +K + Sbjct: 134 ARAKFRQIVSAVQYCHQKF-IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFC 192 Query: 512 GDPQEV-------------KRDLEDLGRLVLYVVKKGSISFE 540 G P + D+ LG ++LY + GS+ F+ Sbjct: 193 GSPPYAAPELFQGKKYDGPEVDVWSLG-VILYTLVSGSLPFD 233 >5E8V-A nrPDB Length = 316 Score = 29.3 bits (64), Expect = 6.8, Method: Compositional matrix adjust. Identities = 22/74 (29%), Positives = 35/74 (47%), Gaps = 10/74 (13%) Query: 462 RNVLSSIFKAVQELH---LSCG-----YTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD 513 R + SS+ + + LH CG H+DL+ NIL+ + L DF S++ D Sbjct: 115 RKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRL--D 172 Query: 514 PQEVKRDLEDLGRL 527 P DL + G++ Sbjct: 173 PTLSVDDLANSGQV 186 >3DAK-A nrPDB Length = 290 Score = 29.3 bits (64), Expect = 7.2, Method: Compositional matrix adjust. Identities = 33/134 (24%), Positives = 64/134 (47%), Gaps = 15/134 (11%) Query: 385 EKQEVAVKTF----CEGS-PRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQ 439 +K++VA+K C+ S +E+ + S + ++V++Y S + L++ + L Sbjct: 34 KKEKVAIKRINLEKCQTSMDELLKEIQAM-SQCHHPNIVSYYTSFVVKDELWLVMKLLSG 92 Query: 440 TLEACLD-----VHRGEDVENEEDEFA-RNVLSSIFKAVQELHLSCGYTHQDLQPQNILI 493 + LD V +GE DE +L + + ++ LH + G H+D++ NIL+ Sbjct: 93 G--SVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKN-GQIHRDVKAGNILL 149 Query: 494 DSKKAAHLADFDKS 507 + +ADF S Sbjct: 150 GEDGSVQIADFGVS 163 >4CSV-A nrPDB Length = 275 Score = 28.9 bits (63), Expect = 7.6, Method: Compositional matrix adjust. Identities = 42/210 (20%), Positives = 77/210 (36%), Gaps = 33/210 (15%) Query: 370 KIADTSEGGIYLGFYEKQ--EVAVKTFCEGSPRAQREVSCLQSSRENSH--LVTFYGSES 425 K+ G +Y G + EVAVKT EG+ + + Q ++ H LV YG + Sbjct: 18 KLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQIMKKLKHPNLVQLYGVCT 77 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 +++ + LD R + + ++ + + + L S + H+D Sbjct: 78 KEPPIYIITEYMSHG--SLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLE-SQNFIHRD 134 Query: 486 LQPQNILIDSKKAAHLADFDKS-----------------IKWAGDPQ------EVKRDLE 522 L +N L+ +ADF + IKW +K D+ Sbjct: 135 LAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAPEAISYNRFSIKSDVW 194 Query: 523 DLGRLVLYVVKKGSISFEDLKAQSNEEVVQ 552 G L+ + G + + + S EV++ Sbjct: 195 AFGILLWEIFTYGQVPYPGM---SGSEVIE 221 >6C9D-A nrPDB Length = 459 Score = 28.9 bits (63), Expect = 7.6, Method: Compositional matrix adjust. Identities = 27/102 (26%), Positives = 43/102 (42%), Gaps = 24/102 (23%) Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF---------DKSIKWA 511 AR I AVQ H H+DL+ +N+L+D +ADF +K ++ Sbjct: 122 ARAKFRQIVSAVQYCHQKY-IVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFC 180 Query: 512 GDPQEV-------------KRDLEDLGRLVLYVVKKGSISFE 540 G P + D+ LG ++LY + GS+ F+ Sbjct: 181 GSPPYAAPELFQGKKYDGPEVDVWSLG-VILYTLVSGSLPFD 221 >3SXS-A nrPDB Length = 268 Score = 28.9 bits (63), Expect = 7.7, Method: Compositional matrix adjust. Identities = 56/223 (25%), Positives = 89/223 (39%), Gaps = 47/223 (21%) Query: 377 GGIYLGFYEKQ-EVAVKTFCEGSPRAQREVSCLQSSRENSH--LVTFYGSESHRGHLFVC 433 G + LG ++ Q +VAVK EGS Q+ + SH LV FYG S +++ Sbjct: 22 GVVKLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYI- 80 Query: 434 VTLCEQTLEACLDVH---RGEDVENEED-EFARNVLSSIFKAVQELHLSCGYTHQDLQPQ 489 + E CL + G+ +E + E +V + A E H + H+DL + Sbjct: 81 --VTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGM--AFLESH---QFIHRDLAAR 133 Query: 490 NILIDSKKAAHLADFDKS-----------------IKWAGD------PQEVKRDLEDLGR 526 N L+D ++DF + +KW+ K D+ G Sbjct: 134 NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI 193 Query: 527 LVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHP 569 L+ V G + + DL S E V+++S HRL+ P Sbjct: 194 LMWEVFSLGKMPY-DLYTNS-EVVLKVSQG-------HRLYRP 227 >1KOB-A nrPDB Length = 387 Score = 28.9 bits (63), Expect = 7.9, Method: Compositional matrix adjust. Identities = 33/138 (23%), Positives = 54/138 (39%), Gaps = 33/138 (23%) Query: 482 THQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKR--------------DLEDLGR- 526 H D++P+NI+ ++KKA+ + D + +P E+ + D E +G Sbjct: 171 VHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIVDREPVGFY 230 Query: 527 -------LVLYVVKKGSISF---EDLKAQSNEEVVQLSPDE--------ETKDLIHRLFH 568 ++ YV+ G F +DL+ N + DE E KD I L Sbjct: 231 TDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSSVSPEAKDFIKNLLQ 290 Query: 569 PGEHVRDCLSDLLGHPFF 586 R + D L HP+ Sbjct: 291 KEPRKRLTVHDALEHPWL 308 >4FG9-A nrPDB Length = 320 Score = 28.9 bits (63), Expect = 8.0, Method: Compositional matrix adjust. Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 8/80 (10%) Query: 428 GHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQ 487 GHL++ + L V +G E + A ++ + AV+ LH G H+DL+ Sbjct: 89 GHLYLIMQLVSGGELFDRIVEKGFYTERD----ASRLIFQVLDAVKYLH-DLGIVHRDLK 143 Query: 488 PQNIL---IDSKKAAHLADF 504 P+N+L +D ++DF Sbjct: 144 PENLLYYSLDEDSKIMISDF 163 >2YCR-A nrPDB Length = 323 Score = 28.9 bits (63), Expect = 8.2, Method: Compositional matrix adjust. Identities = 13/27 (48%), Positives = 21/27 (77%), Gaps = 1/27 (3%) Query: 471 AVQELHLSCGYTHQDLQPQNILIDSKK 497 AVQ LH + G H+DL+P+N+L+ S++ Sbjct: 126 AVQYLHEN-GIIHRDLKPENVLLSSQE 151 >5VD3-A nrPDB Length = 311 Score = 28.9 bits (63), Expect = 8.4, Method: Compositional matrix adjust. Identities = 21/77 (27%), Positives = 34/77 (44%), Gaps = 5/77 (6%) Query: 428 GHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQ 487 G L++ LC +L+ + E + + R+ L A+ LH S G H D++ Sbjct: 130 GILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTL----LALAHLH-SQGLVHLDVK 184 Query: 488 PQNILIDSKKAAHLADF 504 P NI + + L DF Sbjct: 185 PANIFLGPRGRCKLGDF 201 >3I6U-A nrPDB Length = 419 Score = 28.9 bits (63), Expect = 8.4, Method: Compositional matrix adjust. Identities = 13/27 (48%), Positives = 21/27 (77%), Gaps = 1/27 (3%) Query: 471 AVQELHLSCGYTHQDLQPQNILIDSKK 497 AVQ LH + G H+DL+P+N+L+ S++ Sbjct: 251 AVQYLHEN-GIIHRDLKPENVLLSSQE 276 >4XEY-B nrPDB Length = 408 Score = 28.5 bits (62), Expect = 9.9, Method: Compositional matrix adjust. Identities = 59/255 (23%), Positives = 89/255 (34%), Gaps = 40/255 (15%) Query: 263 HIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLS 322 H IN T SDGK L ++ E + +AEL+ ST L+ T L Sbjct: 58 HYRIN-TASDGK--LYVSSESRFNTLAELVHHH--STVADGLITT-------------LH 99 Query: 323 HGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLG 382 + A + P P W D I K+K+ G +Y G Sbjct: 100 YPAPKRNKPTVYGVSPNYDKWEMERTD---------------ITMKHKLGGGQYGEVYEG 144 Query: 383 FYEKQE--VAVKTFCEGSPRAQREVSCLQSSRENSH--LVTFYGSESHRGHLFVCVTLCE 438 ++K VAVKT E + + + +E H LV G + ++ Sbjct: 145 VWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEF-- 202 Query: 439 QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA 498 T LD R E E + +++ + E + H+DL +N L+ Sbjct: 203 MTYGNLLDYLR-ECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHL 261 Query: 499 AHLADFDKSIKWAGD 513 +ADF S GD Sbjct: 262 VKVADFGLSRLMTGD 276 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4OAU-C nrPDB 986 0.0 4O1O-A nrPDB 890 0.0 4PL5-B nrPDB 383 e-106 6HV0-A nrPDB 374 e-104 2RIO-A nrPDB 328 5e-90 5JHQ-A nrPDB 275 7e-74 5HKP-A nrPDB 257 1e-68 5ET1-A nrPDB 248 6e-66 6BY9-A nrPDB 231 7e-61 3B7B-A nrPDB 216 3e-56 5AQA-A nrPDB 213 2e-55 5AQ9-A nrPDB 210 2e-54 2DWZ-A nrPDB 207 2e-53 4JXF-A nrPDB 205 5e-53 4NIK-A nrPDB 204 1e-52 3DB8-A nrPDB 204 1e-52 5AQB-A nrPDB 203 3e-52 5AQ7-A nrPDB 203 3e-52 3M42-A nrPDB 203 3e-52 6FES-A nrPDB 202 6e-52 6MWQ-A nrPDB 201 9e-52 3VN9-A nrPDB 198 7e-51 3FME-A nrPDB 198 7e-51 3ALO-A nrPDB 198 9e-51 1WG0-A nrPDB 195 7e-50 4D28-A nrPDB 194 1e-49 3EU9-A nrPDB 193 3e-49 5H76-A nrPDB 191 9e-49 5MIO-C nrPDB 191 1e-48 6AUN-A nrPDB 191 1e-48 4CQG-A nrPDB 186 3e-47 4D2V-A nrPDB 185 5e-47 4CZT-A nrPDB 179 5e-45 4Z68-A nrPDB 175 7e-44 3COM-A nrPDB 172 4e-43 3ZKJ-A nrPDB 169 5e-42 6AO5-A nrPDB 166 4e-41 4LG4-A nrPDB 166 4e-41 2VN9-A nrPDB 165 7e-41 2Y7J-A nrPDB 162 4e-40 4OT9-A nrPDB 162 5e-40 5Z33-A nrPDB 159 4e-39 5GP7-A nrPDB 157 2e-38 6GU6-A nrPDB 150 3e-36 5CBO-A nrPDB 149 3e-36 6EMK-G nrPDB 142 7e-34 4EQM-A nrPDB 140 2e-33 6E2G-A nrPDB 132 5e-31 2KXP-C nrPDB 124 2e-28 2VD5-A nrPDB 124 2e-28 1ZXE-A nrPDB 119 7e-27 5D68-A nrPDB 114 1e-25 1BD8-A nrPDB 112 4e-25 1BLX-B nrPDB 111 1e-24 3T9K-A nrPDB 105 8e-23 3EHQ-A nrPDB 98 1e-20 5DND-A nrPDB 94 2e-19 5UIL-A nrPDB 78 1e-14 Sequences not found previously or not previously below threshold: 3KA0-A nrPDB 190 2e-48 2OZA-A nrPDB 190 2e-48 1NY3-A nrPDB 190 2e-48 4J52-A nrPDB 185 7e-47 2OU7-A nrPDB 184 1e-46 4MVF-A nrPDB 176 4e-44 5FG8-A nrPDB 162 7e-40 3H4J-B nrPDB 161 1e-39 3F3Z-A nrPDB 159 4e-39 4CFF-A nrPDB 159 4e-39 3FXW-A nrPDB 159 5e-39 2V7O-A nrPDB 158 6e-39 5U6Y-A nrPDB 158 7e-39 2VZ6-A nrPDB 157 1e-38 5EZV-A nrPDB 157 2e-38 4REW-A nrPDB 157 2e-38 3SOA-A nrPDB 157 2e-38 4RED-A nrPDB 157 2e-38 4CFH-A nrPDB 155 6e-38 5IG1-A nrPDB 155 7e-38 2YZA-A nrPDB 155 7e-38 3MN3-A nrPDB 155 8e-38 4UZD-A nrPDB 154 1e-37 4I6B-A nrPDB 154 2e-37 4NIF-A nrPDB 153 2e-37 3BHH-A nrPDB 153 2e-37 4B6L-A nrPDB 151 8e-37 2XIK-A nrPDB 151 1e-36 2BDW-A nrPDB 150 2e-36 3NCG-A nrPDB 150 2e-36 3KK8-A nrPDB 149 3e-36 1PHK-A nrPDB 149 4e-36 3D2K-A nrPDB 149 6e-36 3DFA-A nrPDB 148 8e-36 2BPM-A nrPDB 148 1e-35 3DXN-A nrPDB 147 1e-35 2QNJ-A nrPDB 147 1e-35 4JG6-A nrPDB 147 2e-35 4YNZ-A nrPDB 146 3e-35 3HZT-A nrPDB 146 4e-35 3MA6-A nrPDB 145 4e-35 5JN2-A nrPDB 145 5e-35 3LIJ-A nrPDB 145 5e-35 4FG9-A nrPDB 144 1e-34 3NIZ-A nrPDB 144 2e-34 5WAX-A nrPDB 143 3e-34 2YAB-A nrPDB 142 4e-34 2JC6-A nrPDB 142 7e-34 3Q5I-A nrPDB 142 7e-34 5ES1-A nrPDB 141 8e-34 4AU8-A nrPDB 141 8e-34 5YKS-A nrPDB 141 1e-33 5KZ7-A nrPDB 140 2e-33 5B2L-A nrPDB 140 2e-33 4YZB-A nrPDB 139 5e-33 2JAM-A nrPDB 139 5e-33 2A27-A nrPDB 139 6e-33 4QMW-A nrPDB 138 8e-33 3TAC-A nrPDB 138 9e-33 3GUB-A nrPDB 138 1e-32 1ZWS-A nrPDB 137 1e-32 4RGJ-A nrPDB 137 2e-32 4AN9-A nrPDB 137 2e-32 5JZN-A nrPDB 135 6e-32 3IS5-A nrPDB 135 6e-32 6FDY-U nrPDB 135 9e-32 6E2O-A nrPDB 134 9e-32 5XZW-A nrPDB 134 1e-31 3UDB-A nrPDB 133 3e-31 4FZF-B nrPDB 133 3e-31 3ZUT-A nrPDB 133 3e-31 4KRC-A nrPDB 133 3e-31 6CMJ-A nrPDB 133 4e-31 5YV8-A nrPDB 132 4e-31 2J90-A nrPDB 132 5e-31 3UC3-A nrPDB 131 8e-31 2W4O-A nrPDB 130 1e-30 2HAK-A nrPDB 130 2e-30 6C9D-A nrPDB 130 2e-30 2HW6-A nrPDB 130 2e-30 4PDS-A nrPDB 130 2e-30 2YCR-A nrPDB 130 2e-30 1FOT-A nrPDB 130 3e-30 5D7A-A nrPDB 130 3e-30 5KCV-A nrPDB 129 4e-30 6QAU-A nrPDB 128 7e-30 3MV5-A nrPDB 127 1e-29 4APC-A nrPDB 127 2e-29 2XNP-A nrPDB 127 2e-29 3I6U-A nrPDB 127 2e-29 2BRG-A nrPDB 126 3e-29 5J5T-A nrPDB 126 3e-29 1V0B-A nrPDB 126 3e-29 4KS7-A nrPDB 126 4e-29 6HXF-B nrPDB 126 4e-29 4B8L-A nrPDB 125 4e-29 2RFA-A nrPDB 125 5e-29 2F57-A nrPDB 125 5e-29 3KN6-A nrPDB 124 1e-28 5N23-A nrPDB 124 1e-28 2X4F-A nrPDB 124 1e-28 4AF3-A nrPDB 124 2e-28 4JDH-A nrPDB 123 2e-28 2WQN-A nrPDB 123 3e-28 3HKO-A nrPDB 123 3e-28 3ORZ-A nrPDB 123 3e-28 4FIE-A nrPDB 123 3e-28 6BOA-A nrPDB 122 4e-28 2WTK-C nrPDB 122 5e-28 1U5R-A nrPDB 122 6e-28 3DAK-A nrPDB 122 6e-28 4L42-A nrPDB 122 6e-28 2Q0N-A nrPDB 122 7e-28 4RLP-A nrPDB 122 7e-28 4IC8-A nrPDB 122 8e-28 4C0T-A nrPDB 122 8e-28 4WB7-A nrPDB 121 1e-27 3EQC-A nrPDB 121 1e-27 2GCD-A nrPDB 121 1e-27 2UV2-A nrPDB 121 1e-27 2JDO-A nrPDB 121 1e-27 3HDN-A nrPDB 121 1e-27 4AGU-A nrPDB 121 1e-27 5G6V-A nrPDB 121 1e-27 5KKR-C nrPDB 121 1e-27 3UTO-A nrPDB 121 1e-27 5DBX-A nrPDB 121 1e-27 4U41-A nrPDB 120 1e-27 4XBR-A nrPDB 120 2e-27 6FD3-A nrPDB 120 2e-27 4WNO-A nrPDB 120 2e-27 6DTL-A nrPDB 120 2e-27 1KOB-A nrPDB 120 2e-27 6CCF-A nrPDB 120 3e-27 1KOA-A nrPDB 119 4e-27 6E9W-A nrPDB 119 5e-27 6BDL-A nrPDB 119 6e-27 3ZDU-A nrPDB 118 7e-27 6CQF-A nrPDB 118 8e-27 6ED6-A nrPDB 118 9e-27 3BGP-A nrPDB 118 9e-27 1G3N-A nrPDB 118 1e-26 3OZ6-A nrPDB 118 1e-26 4ZSG-A nrPDB 118 1e-26 5F9E-A nrPDB 118 1e-26 1S9I-A nrPDB 117 1e-26 5LOH-A nrPDB 117 2e-26 3A8W-A nrPDB 117 2e-26 5VO2-A nrPDB 117 2e-26 6CKI-A nrPDB 117 2e-26 5X3F-B nrPDB 117 2e-26 4RC3-A nrPDB 117 2e-26 5TUR-A nrPDB 116 3e-26 1JNK-A nrPDB 116 3e-26 2F9G-A nrPDB 116 4e-26 4QTB-A nrPDB 116 4e-26 4X7Q-B nrPDB 116 4e-26 3Q53-A nrPDB 115 5e-26 3TXO-A nrPDB 115 5e-26 3TKU-A nrPDB 115 6e-26 4BBM-A nrPDB 115 1e-25 5D9K-A nrPDB 115 1e-25 1VZO-A nrPDB 114 1e-25 4E7W-A nrPDB 114 2e-25 3E7O-A nrPDB 114 2e-25 3LM0-A nrPDB 114 2e-25 3FI2-A nrPDB 114 2e-25 4AW2-A nrPDB 113 3e-25 5NGU-A nrPDB 113 3e-25 4MYG-A nrPDB 112 5e-25 5AWM-A nrPDB 112 6e-25 5AIR-A nrPDB 112 8e-25 4BGQ-A nrPDB 111 1e-24 2Z7Q-A nrPDB 110 2e-24 5FET-A nrPDB 110 2e-24 3OHT-A nrPDB 110 2e-24 5DYK-A nrPDB 110 3e-24 3E3P-A nrPDB 110 3e-24 4C59-A nrPDB 109 4e-24 2XS0-A nrPDB 109 5e-24 3GC0-A nrPDB 108 1e-23 5AP3-A nrPDB 108 1e-23 1UA2-A nrPDB 107 1e-23 6GVJ-A nrPDB 107 1e-23 3PG1-A nrPDB 107 2e-23 2W96-B nrPDB 107 2e-23 4CSV-A nrPDB 107 2e-23 4EBW-A nrPDB 107 3e-23 3HMP-A nrPDB 106 3e-23 2A1A-B nrPDB 106 4e-23 2ZMD-A nrPDB 105 5e-23 3PPZ-A nrPDB 105 5e-23 3C51-A nrPDB 105 6e-23 2J0K-A nrPDB 105 8e-23 3UIU-A nrPDB 105 8e-23 4EWQ-A nrPDB 105 1e-22 4GS6-A nrPDB 105 1e-22 5VD3-A nrPDB 104 1e-22 5O2C-A nrPDB 104 1e-22 2I6L-A nrPDB 104 1e-22 1CM8-A nrPDB 104 1e-22 4QNY-A nrPDB 104 2e-22 1TKI-A nrPDB 104 2e-22 4PWN-A nrPDB 104 2e-22 5O2B-A nrPDB 103 3e-22 3LJN-A nrPDB 103 3e-22 5EFQ-A nrPDB 103 4e-22 4RA4-A nrPDB 102 6e-22 5HI2-A nrPDB 102 6e-22 5O0Y-A nrPDB 102 6e-22 6DMR-A nrPDB 102 6e-22 3NYO-A nrPDB 102 7e-22 3DLS-A nrPDB 102 8e-22 2H8H-A nrPDB 101 1e-21 5HIE-A nrPDB 100 2e-21 4NST-A nrPDB 100 2e-21 4FR4-A nrPDB 100 2e-21 6F3F-A nrPDB 100 2e-21 3MIA-A nrPDB 100 2e-21 5SYS-A nrPDB 100 3e-21 4H1J-A nrPDB 99 5e-21 4O2Z-A nrPDB 99 6e-21 3GC9-A nrPDB 99 9e-21 4TNB-A nrPDB 99 1e-20 6NPU-A nrPDB 98 1e-20 4XEY-B nrPDB 98 1e-20 5UUU-A nrPDB 98 1e-20 5MJB-A nrPDB 98 1e-20 1AD5-A nrPDB 98 1e-20 2PL0-A nrPDB 98 2e-20 3PVW-A nrPDB 97 2e-20 5X5O-A nrPDB 97 2e-20 3CJF-A nrPDB 97 2e-20 3EB0-A nrPDB 97 2e-20 1K9A-A nrPDB 97 2e-20 2XYN-A nrPDB 97 3e-20 6BXI-A nrPDB 97 3e-20 5TE0-A nrPDB 97 3e-20 2PMN-X nrPDB 96 4e-20 2FO0-A nrPDB 96 5e-20 1U59-A nrPDB 96 7e-20 1FVR-A nrPDB 96 8e-20 4UY9-A nrPDB 96 8e-20 1BYG-A nrPDB 95 1e-19 3DTC-A nrPDB 95 1e-19 3A4O-X nrPDB 94 1e-19 3SXS-A nrPDB 94 2e-19 3PFQ-A nrPDB 94 2e-19 2I0E-A nrPDB 94 2e-19 3OMV-A nrPDB 94 2e-19 5H2U-A nrPDB 94 3e-19 4E93-A nrPDB 94 3e-19 3KUL-B nrPDB 93 4e-19 2DQ7-X nrPDB 92 5e-19 3N9X-A nrPDB 92 6e-19 2OZO-A nrPDB 92 6e-19 2R2P-A nrPDB 92 6e-19 4UYA-A nrPDB 92 9e-19 3DKO-A nrPDB 92 9e-19 5AMN-A nrPDB 92 1e-18 5L6P-A nrPDB 92 1e-18 5IKW-A nrPDB 92 1e-18 1JPA-A nrPDB 91 1e-18 3NIE-A nrPDB 91 2e-18 3QGY-A nrPDB 91 2e-18 4P5Q-A nrPDB 91 2e-18 5FM2-A nrPDB 91 2e-18 4YFF-A nrPDB 90 3e-18 5GNK-A nrPDB 90 4e-18 2PSQ-A nrPDB 89 5e-18 3RP9-A nrPDB 89 6e-18 6E4F-A nrPDB 89 7e-18 4XI2-A nrPDB 89 7e-18 4PDO-A nrPDB 89 7e-18 4AT3-A nrPDB 89 8e-18 3ORP-A nrPDB 89 8e-18 3LZB-A nrPDB 89 8e-18 2HK5-A nrPDB 89 8e-18 5X02-A nrPDB 89 8e-18 4XUF-A nrPDB 89 8e-18 4IAN-A nrPDB 89 9e-18 4YHJ-A nrPDB 89 9e-18 5VC6-A nrPDB 88 1e-17 4Y93-A nrPDB 88 1e-17 4BTK-A nrPDB 88 1e-17 4M7I-A nrPDB 88 1e-17 6O6Q-A nrPDB 88 2e-17 6DVZ-A nrPDB 88 2e-17 6DC0-A nrPDB 87 2e-17 5CEK-A nrPDB 87 2e-17 3BBT-B nrPDB 87 2e-17 4NFN-A nrPDB 87 2e-17 2VWV-A nrPDB 87 2e-17 2Y6O-A nrPDB 87 3e-17 6GQK-A nrPDB 87 4e-17 5GRN-A nrPDB 86 4e-17 3TT0-A nrPDB 86 5e-17 3QUP-A nrPDB 86 6e-17 3V5Q-A nrPDB 86 6e-17 4N5Q-A nrPDB 86 7e-17 1G3N-B nrPDB 86 8e-17 5KMM-A nrPDB 85 9e-17 4XCU-A nrPDB 85 1e-16 5EG3-A nrPDB 85 1e-16 6CTH-A nrPDB 85 1e-16 5HVK-A nrPDB 84 2e-16 3GQL-A nrPDB 84 2e-16 4XLV-A nrPDB 84 3e-16 5A46-A nrPDB 84 3e-16 2WO6-A nrPDB 83 4e-16 2W1I-A nrPDB 83 5e-16 4LRM-A nrPDB 83 5e-16 2Y4I-B nrPDB 82 6e-16 3IO7-A nrPDB 82 7e-16 5ZTN-A nrPDB 82 7e-16 4CRS-A nrPDB 82 9e-16 5UIU-A nrPDB 82 9e-16 5TOS-A nrPDB 82 1e-15 3I81-A nrPDB 82 1e-15 1D9S-A nrPDB 82 1e-15 5VDK-A nrPDB 81 1e-15 5Y86-A nrPDB 81 2e-15 3G0E-A nrPDB 81 2e-15 4CRL-A nrPDB 81 2e-15 5LPZ-A nrPDB 81 2e-15 4K33-A nrPDB 81 2e-15 4HVI-A nrPDB 81 2e-15 5X8I-B nrPDB 81 3e-15 4OTD-A nrPDB 81 3e-15 6OO7-A nrPDB 80 3e-15 5C26-A nrPDB 80 3e-15 2OGV-A nrPDB 80 3e-15 4Y83-A nrPDB 80 3e-15 5U6B-A nrPDB 80 4e-15 5XVU-A nrPDB 80 4e-15 4NEU-A nrPDB 80 4e-15 3AOX-A nrPDB 80 4e-15 5LPV-A nrPDB 80 4e-15 4LQP-A nrPDB 80 5e-15 3ZZW-A nrPDB 79 5e-15 4FL3-A nrPDB 79 6e-15 3QD2-B nrPDB 79 7e-15 2QKW-B nrPDB 79 7e-15 5WNO-A nrPDB 79 1e-14 3PLS-A nrPDB 78 1e-14 3DEO-A nrPDB 78 1e-14 5AN8-A nrPDB 78 1e-14 3UI2-A nrPDB 78 1e-14 2BUJ-A nrPDB 78 1e-14 3BEA-A nrPDB 78 2e-14 4MD7-E nrPDB 77 2e-14 4IDT-A nrPDB 77 2e-14 3VHK-A nrPDB 77 2e-14 2PVN-A nrPDB 77 2e-14 4LFI-A nrPDB 77 2e-14 6HMD-A nrPDB 77 2e-14 2A5E-A nrPDB 77 3e-14 6DBN-A nrPDB 77 3e-14 2F37-A nrPDB 77 3e-14 6EII-A nrPDB 77 3e-14 4F0G-A nrPDB 77 3e-14 4JLC-A nrPDB 77 4e-14 3RAW-A nrPDB 76 4e-14 3KRL-A nrPDB 76 4e-14 6BFN-A nrPDB 76 4e-14 3HNG-A nrPDB 76 4e-14 3PP0-A nrPDB 76 4e-14 4EUU-A nrPDB 76 5e-14 4EUT-A nrPDB 76 5e-14 4R7H-A nrPDB 76 6e-14 4G3E-A nrPDB 76 6e-14 6O8B-A nrPDB 76 7e-14 6NT9-A nrPDB 75 1e-13 6BO5-A nrPDB 75 1e-13 5HI9-A nrPDB 75 1e-13 4OW8-A nrPDB 75 1e-13 4X3F-A nrPDB 75 1e-13 6B2Q-A nrPDB 75 1e-13 6FEX-A nrPDB 75 1e-13 6FYV-A nrPDB 74 2e-13 6J5U-C nrPDB 74 2e-13 6DBM-A nrPDB 74 2e-13 2ETB-A nrPDB 74 2e-13 3QA8-A nrPDB 74 2e-13 4E20-A nrPDB 74 3e-13 4TPT-A nrPDB 74 3e-13 3SV0-A nrPDB 74 3e-13 4OLI-A nrPDB 73 4e-13 6FER-A nrPDB 73 4e-13 1LUF-A nrPDB 73 4e-13 2JD5-A nrPDB 73 5e-13 5FQD-C nrPDB 72 6e-13 5HLW-A nrPDB 72 6e-13 6BSD-A nrPDB 72 7e-13 3Q4U-A nrPDB 72 8e-13 4L00-A nrPDB 72 1e-12 3ZBF-A nrPDB 72 1e-12 3MDY-A nrPDB 71 1e-12 3G2F-A nrPDB 71 1e-12 4KIK-B nrPDB 70 2e-12 5TQX-A nrPDB 70 2e-12 4TN6-A nrPDB 70 3e-12 4HZS-A nrPDB 70 3e-12 3C1X-A nrPDB 70 3e-12 5IRX-A nrPDB 70 3e-12 5L2Q-C nrPDB 70 3e-12 4F9B-A nrPDB 70 4e-12 2NYJ-A nrPDB 70 4e-12 5U6C-A nrPDB 69 5e-12 1U54-B nrPDB 69 6e-12 1PY5-A nrPDB 69 6e-12 2WTK-B nrPDB 69 6e-12 4MWI-A nrPDB 69 6e-12 4Y12-A nrPDB 69 7e-12 2PZI-A nrPDB 69 7e-12 4M66-A nrPDB 69 7e-12 2H34-A nrPDB 69 8e-12 3UIM-A nrPDB 68 1e-11 5UNP-A nrPDB 68 2e-11 3LMG-A nrPDB 67 2e-11 5WNL-A nrPDB 67 2e-11 4RT7-A nrPDB 67 2e-11 4M69-B nrPDB 67 2e-11 3MY0-A nrPDB 67 3e-11 4BTF-A nrPDB 67 3e-11 5AR8-A nrPDB 67 3e-11 6MHW-A nrPDB 67 4e-11 5X18-A nrPDB 66 4e-11 1DCQ-A nrPDB 66 4e-11 5XD6-A nrPDB 66 5e-11 2CHL-A nrPDB 65 2e-10 3W9G-A nrPDB 64 2e-10 5M07-A nrPDB 64 2e-10 2C47-A nrPDB 64 3e-10 5U0K-A nrPDB 63 4e-10 4XD0-A nrPDB 63 5e-10 4BSZ-B nrPDB 63 5e-10 1CSN-A nrPDB 63 5e-10 5UQE-A nrPDB 63 6e-10 3LLT-A nrPDB 62 7e-10 4NT4-A nrPDB 62 7e-10 5E8V-A nrPDB 62 8e-10 >4OAU-C nrPDB Length = 699 Score = 986 bits (2549), Expect = 0.0, Method: Composition-based stats. Identities = 698/699 (99%), Positives = 699/699 (100%) Query: 21 AAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLR 80 AAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLR Sbjct: 1 AAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLR 60 Query: 81 HGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKA 140 HGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKA Sbjct: 61 HGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKA 120 Query: 141 LKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDN 200 LKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDN Sbjct: 121 LKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDN 180 Query: 201 MGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLE 260 MGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLE Sbjct: 181 MGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLE 240 Query: 261 QEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVL 320 QEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVL Sbjct: 241 QEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVL 300 Query: 321 LSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIY 380 LSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIY Sbjct: 301 LSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIY 360 Query: 381 LGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQT 440 LGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQT Sbjct: 361 LGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQT 420 Query: 441 LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAH 500 LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAH Sbjct: 421 LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAH 480 Query: 501 LADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETK 560 LADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETK Sbjct: 481 LADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETK 540 Query: 561 DLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQP 620 DLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQP Sbjct: 541 DLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQP 600 Query: 621 GPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHIDEEKHKK 680 GPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGE+IDEEKHKK Sbjct: 601 GPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGENIDEEKHKK 660 Query: 681 MKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQT 719 MKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQT Sbjct: 661 MKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQT 699 >4O1O-A nrPDB Length = 717 Score = 890 bits (2300), Expect = 0.0, Method: Composition-based stats. Identities = 504/708 (71%), Positives = 581/708 (82%), Gaps = 12/708 (1%) Query: 28 LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVL 87 +L +AVQ D++ V+QLLE GA+ NFQEEE GW+PLH+AVQM ED+V LLL+HGADP L Sbjct: 11 MLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCL 70 Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147 RK+NGATPFI+A I G+V+LL+L L DVNECD GFTAFMEAAVYG+V+AL+FLY+ Sbjct: 71 RKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYEN 130 Query: 148 GANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALI 207 GA+VN+ RKTK+DQER+RKGGATALMDAAEKGHV V+ ILL M A+V+A DNMGRNAL+ Sbjct: 131 GADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALV 190 Query: 208 HALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEIN 267 +ALL+ DD +AIT LLLDHGADVNVRGE KTPLILAVE+K+L LVQ LLEQE IE+N Sbjct: 191 YALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVN 250 Query: 268 DTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKE 327 DTD +GKTALLLAVEL+L++IA+LLC RGAST+CGDLV ARRNYD LVK L H A E Sbjct: 251 DTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHKAGE 310 Query: 328 DFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQ 387 DF PPAE+WKPQSS WG ALK LHRI+RPMIGKLK FIDE+YKIADT+EGGIYLG YE Q Sbjct: 311 DFRPPAENWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYEDQ 370 Query: 388 EVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDV 447 EVAVK F EGS R Q+EVSCLQSSR N ++VTFYGSES L VC+ LCE TL+ L Sbjct: 371 EVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLAN 430 Query: 448 HRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 HRG+ V NEEDE ARN+LSS+FKA+ ELH S GY+HQDLQPQNILIDSK LADFDKS Sbjct: 431 HRGDAVPNEEDESARNILSSLFKAIGELHRS-GYSHQDLQPQNILIDSKNGTFLADFDKS 489 Query: 508 IKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLF 567 IKWA DPQ++KRDLE LG LVLYVVKKG ISFE LK QS EEV+Q SPDEET+DLIH LF Sbjct: 490 IKWAEDPQKIKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLF 549 Query: 568 HPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSK 627 HPG++V D LS LL HPFFW+WESRYRTLR+VGNESDIKTR S IL+LLQPG SE S Sbjct: 550 HPGDNVEDRLSSLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPGTSELST 609 Query: 628 SFDKWTTKINECVMKKMNKFY-----------EKRGNFYQNTVGDLLKFIRNLGEHIDEE 676 SF +WTTKI+ VM++MN +Y GN YQ+T+GDLLKFIRNLGEHI+E+ Sbjct: 610 SFAQWTTKIDSFVMEEMNAYYKKISKKKKAKHTNEGNLYQDTLGDLLKFIRNLGEHINEQ 669 Query: 677 KHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQTHSPNK 724 K+KKMK IG+PS YFQ+ FPDLV+YVYTKLQNTEY KHFP+TH+PNK Sbjct: 670 KNKKMKSIIGEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKTHNPNK 717 Score = 93.6 bits (231), Expect = 3e-19, Method: Composition-based stats. Identities = 47/201 (23%), Positives = 75/201 (37%), Gaps = 24/201 (11%) Query: 13 PTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEE---------GGWTPL 63 P V ++A V+ ++ L E GA+VN + GG T L Sbjct: 96 PNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATAL 155 Query: 64 HNAVQMSREDIVELLLRHG-ADPVLRKKNGATPFILAAIA---GSVK-LLKLFLSKGADV 118 +A + +V +LL A+ R G + A + G K + +L L GADV Sbjct: 156 MDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGADV 215 Query: 119 NECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEK 178 N T + A + ++ L + + + + + G TAL+ A E Sbjct: 216 NVRGEGSKTPLILAVERKNLDLVQMLLE---------QEQIEVNDTDREGKTALLLAVEL 266 Query: 179 GHVEVLKILLDEMGADVNACD 199 E+ K+L GA N D Sbjct: 267 RLEEIAKLLCHR-GASTNCGD 286 >4PL5-B nrPDB Length = 435 Score = 383 bits (983), Expect = e-106, Method: Composition-based stats. Identities = 100/421 (23%), Positives = 170/421 (40%), Gaps = 67/421 (15%) Query: 357 MIGKLKFFIDEKYKIADTSEGG-IYLGFYEKQEVAVKTF-CEGSPRAQREVSCLQSSREN 414 ++GK+ F K + +EG +Y G ++ ++VAVK E A REV L+ S E+ Sbjct: 23 IVGKISFC--PKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEH 80 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 +++ ++ +E R ++ + LC TL+ ++ + E +L + Sbjct: 81 PNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEP----ITLLHQTTSGLAH 136 Query: 475 LHLSCGYTHQDLQPQNILIDSKKA-----AHLADFDKSIKWAGDPQEVKR---------- 519 LH S H+DL+P NIL+ A A ++DF K A R Sbjct: 137 LH-SLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGW 195 Query: 520 ------------------DLEDLGRLVLYVVKKGSISF-EDLKAQSNEEVVQL------- 553 D+ G + YV+ +G F + L+ Q+N + Sbjct: 196 IAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILLGACNLDCFHS 255 Query: 554 --SPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSE 611 D ++LI ++ R +L HPFFW+ E + + ++V + I+ + Sbjct: 256 DKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQDVSDR--IEKEALD 313 Query: 612 SEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGE 671 I+R L+ G K W I + + KF +G +V DLL+ +RN Sbjct: 314 GPIVRQLERGGRAVVKM--DWRENITVPLQTDLRKFRTYKG----GSVRDLLRAMRNKKH 367 Query: 672 HIDE---EKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQT---HSPNKP 725 H E E + + D YF FP L+ + Y ++ + + F QT H P +P Sbjct: 368 HYRELPVEVQETLGSIPDDFVRYFTSRFPHLLSHTYQAMELCRHERLF-QTYYWHEPTEP 426 Query: 726 Q 726 Q Sbjct: 427 Q 427 >6HV0-A nrPDB Length = 416 Score = 374 bits (960), Expect = e-104, Method: Composition-based stats. Identities = 96/408 (23%), Positives = 165/408 (40%), Gaps = 63/408 (15%) Query: 357 MIGKLKFFIDEKYKIADTSEGG-IYLGFYEKQEVAVKTF-CEGSPRAQREVSCLQSSREN 414 ++GK+ F K + +EG +Y G ++ ++VAVK E A REV L+ S E+ Sbjct: 4 IVGKISFC--PKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEH 61 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 +++ ++ +E R ++ + LC TL+ ++ + E +L + Sbjct: 62 PNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEP----ITLLQQTTSGLAH 117 Query: 475 LHLSCGYTHQDLQPQNILIDSKKA-----AHLADFDKSIKWAGDPQEVKR---------- 519 LH S H+DL+P NILI A A ++DF K A R Sbjct: 118 LH-SLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGW 176 Query: 520 ------------------DLEDLGRLVLYVVKKGSISF-EDLKAQSNEEVVQLS------ 554 D+ G + YV+ +GS F + L+ Q+N + S Sbjct: 177 IAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHP 236 Query: 555 ---PDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSE 611 D ++LI ++ R +L HPFFW+ E + + ++V + I+ + Sbjct: 237 EKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDR--IEKESLD 294 Query: 612 SEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGE 671 I++ L+ G K W I + + KF +G +V DLL+ +RN Sbjct: 295 GPIVKQLERGGRAVVKM--DWRENITVPLQTDLRKFRTYKG----GSVRDLLRAMRNKKH 348 Query: 672 HIDE---EKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHF 716 H E E + + D YF FP L+ + Y ++ + + F Sbjct: 349 HYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLF 396 >2RIO-A nrPDB Length = 434 Score = 328 bits (841), Expect = 5e-90, Method: Composition-based stats. Identities = 91/411 (22%), Positives = 153/411 (37%), Gaps = 78/411 (18%) Query: 362 KFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFC-EGSPRAQREVSCLQSSRENSHLVTF 420 + EK +S ++ G ++ + VAVK + A E+ L S ++ +++ + Sbjct: 15 NLVVSEKILGYGSSGTVVFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRY 74 Query: 421 YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNV-----LSSIFKAVQEL 475 Y SE+ L++ + LC L+ D+ ++V +E + + L I V L Sbjct: 75 YCSETTDRFLYIALELCNLNLQ---DLVESKNVSDENLKLQKEYNPISLLRQIASGVAHL 131 Query: 476 HLSCGYTHQDLQPQNILID-------------SKKAAHLADFDKSIKWAGDPQEVKR--- 519 H S H+DL+PQNIL+ ++DF K + Sbjct: 132 H-SLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLN 190 Query: 520 ------------------------------DLEDLGRLVLYVVKKGSISFEDLKAQSNEE 549 D+ +G + Y++ KG F D K Sbjct: 191 NPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGD-KYSRESN 249 Query: 550 VVQ--LSPDE-----------ETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTL 596 +++ S DE E DLI ++ R +L HP FW + L Sbjct: 250 IIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFL 309 Query: 597 RNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQ 656 V + +I+ R S +L G S D WT K ++ M + E+ ++ Sbjct: 310 LKVSDRLEIENRDPPSALLMKFDAGSDFVIPSGD-WTVKFDKTFMDNL----ERYRKYHS 364 Query: 657 NTVGDLLKFIRNLGEHIDEEKHKKMKLKIGDPSL---YFQKTFPDLVIYVY 704 + + DLL+ +RN H + +L P YF K FP+L+I VY Sbjct: 365 SKLMDLLRALRNKYHHFMDLPEDIAELMGPVPDGFYDYFTKRFPNLLIGVY 415 >5JHQ-A nrPDB Length = 482 Score = 275 bits (702), Expect = 7e-74, Method: Composition-based stats. Identities = 87/281 (30%), Positives = 129/281 (45%), Gaps = 17/281 (6%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEG-GWTPLHNAVQMSREDIVELLLRHGADPVL 87 L++A +N DV V++L++ ANVN ++ G +PLH A R+D+VE LL+ GA+ Sbjct: 19 LLEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 77 Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147 R G P A G +++ L L +GAD N D + +T EAA+ GK+ L + Sbjct: 78 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 137 Query: 148 GANVNLRRKTKEDQERLRKGGATA----------LMDAAEKGHVEVLKILLDEMGADVNA 197 GA+ N+R + L A A L++AA G+ E L LL + + +A Sbjct: 138 GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA 197 Query: 198 CDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQR 257 D L A + I LLL HGADV+ + + G PL A H + + Sbjct: 198 SDGRKSTPLHLAA----GYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 253 Query: 258 LLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAS 298 LL + +N D T L A ++ LL GA Sbjct: 254 LL-KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGAD 293 Score = 259 bits (661), Expect = 4e-69, Method: Composition-based stats. Identities = 92/307 (29%), Positives = 139/307 (45%), Gaps = 18/307 (5%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEG-GWTPLHNAVQMSREDIVELLLRHGADPVL 87 L++A ++ + + + LL NVN +G TPLH A +R IV+LLL+HGAD Sbjct: 172 LLEAARSGNEEKLMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHA 230 Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147 + K G P A G ++ +L L GA VN D + FT EAA +V+ L Sbjct: 231 KDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH 290 Query: 148 GAN---VNLRRK-------TKEDQERLRK--GGATALMDAAEKGHVEVLKILLDEMGADV 195 GA+ VN K T E +ERL G + L A E +V K L E+ + Sbjct: 291 GADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEI---I 347 Query: 196 NACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLV 255 N +H ++S + +T LLL GA+VN + + TPL +A E+ H ++ Sbjct: 348 NFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVM 407 Query: 256 QRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHS 315 + L + ++N D+ G+TAL A + LL G+ L + Sbjct: 408 EVL-HKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNE 466 Query: 316 LVKVLLS 322 V+ +LS Sbjct: 467 AVQQILS 473 Score = 117 bits (293), Expect = 2e-26, Method: Composition-based stats. Identities = 47/180 (26%), Positives = 79/180 (43%), Gaps = 19/180 (10%) Query: 12 GPTSSSGRRAAVE-DNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMS 70 PT R E H L++A + D+ V++ L +NF++ + T LH AV Sbjct: 308 APTPELRERLTYEFKGHSLLQAAREADLAKVKKTLAL-EIINFKQPQSHETALHCAVASL 366 Query: 71 R---EDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFT 127 + + ELLLR GA+ + K+ TP +AA ++++ GA +N D G T Sbjct: 367 HPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQT 426 Query: 128 AFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKIL 187 A AA+ G ++ + L G++ ++ AA+ G+ V +IL Sbjct: 427 ALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT--------------AAQMGNEAVQQIL 472 Score = 103 bits (256), Expect = 3e-22, Method: Composition-based stats. Identities = 41/157 (26%), Positives = 67/157 (42%), Gaps = 5/157 (3%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 L++A G V +K L+D A+VNA D GR + L + + + LL GA+ Sbjct: 19 LLEACRNGDVSRVKRLVDA--ANVNAKDMAGRKS--SPLHFAAGFGRKDVVEHLLQMGAN 74 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAEL 291 V+ R + G PL A H +V LL + + N D+ T L A + + Sbjct: 75 VHARDDGGLIPLHNACSFGHAEVVSLLL-CQGADPNARDNWNYTPLHEAAIKGKIDVCIV 133 Query: 292 LCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKED 328 L + GA + + + + K +L+ K+D Sbjct: 134 LLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKD 170 Score = 77.4 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 32/135 (23%), Positives = 51/135 (37%), Gaps = 10/135 (7%) Query: 205 ALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGK--TPLILAVEKKHLGLVQRLLEQE 262 AL L + + DV + L+ A+VN + G+ +PL A +V+ LL Q Sbjct: 15 ALRELLEACRNGDVSRVKRLVDA--ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLL-QM 71 Query: 263 HIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYD-----HSLV 317 ++ D G L A ++ LL +GA + D + + Sbjct: 72 GANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVC 131 Query: 318 KVLLSHGAKEDFHPP 332 VLL HGA + Sbjct: 132 IVLLQHGADPNIRNT 146 >5HKP-A nrPDB Length = 351 Score = 257 bits (656), Expect = 1e-68, Method: Composition-based stats. Identities = 92/307 (29%), Positives = 138/307 (44%), Gaps = 18/307 (5%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEG-GWTPLHNAVQMSREDIVELLLRHGADPVL 87 L++A ++ + + + LL NVN +G TPLH A +R IV+LLL+HGAD Sbjct: 28 LLEAARSGNEEKLMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHA 86 Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147 + K G P A G ++ +L L GA VN D + FT EAA +V+ L Sbjct: 87 KDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH 146 Query: 148 GAN---VNLRRK-------TKEDQERLRK--GGATALMDAAEKGHVEVLKILLDEMGADV 195 GA+ VN K T E +ERL G + L A E +V K L E+ + Sbjct: 147 GADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEI---I 203 Query: 196 NACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLV 255 N +H ++S + + LLL GA+VN + + TPL +A E+ H ++ Sbjct: 204 NFKQPQSHETALHCAVASLHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVM 263 Query: 256 QRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHS 315 + L + ++N DS G+TAL A + LL G+ L + Sbjct: 264 EVL-HKHGAKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNE 322 Query: 316 LVKVLLS 322 V+ +LS Sbjct: 323 AVQQILS 329 Score = 116 bits (291), Expect = 3e-26, Method: Composition-based stats. Identities = 47/180 (26%), Positives = 79/180 (43%), Gaps = 19/180 (10%) Query: 12 GPTSSSGRRAAVE-DNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMS 70 PT R E H L++A + D+ V++ L +NF++ + T LH AV Sbjct: 164 APTPELRERLTYEFKGHSLLQAAREADLAKVKKTLAL-EIINFKQPQSHETALHCAVASL 222 Query: 71 R---EDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFT 127 + + ELLLR GA+ + K+ TP +AA ++++ GA +N D G T Sbjct: 223 HPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDSLGQT 282 Query: 128 AFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKIL 187 A AA+ G ++ + L G++ ++ AA+ G+ V +IL Sbjct: 283 ALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT--------------AAQMGNEAVQQIL 328 >5ET1-A nrPDB Length = 353 Score = 248 bits (633), Expect = 6e-66, Method: Composition-based stats. Identities = 85/327 (25%), Positives = 137/327 (41%), Gaps = 26/327 (7%) Query: 28 LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADP-V 86 ++A + D+D+++ L G + P+H+A + + + L+ A P V Sbjct: 6 QALQAARRGDLDVLRSLHAAGLLGPSLRDSLDALPVHHAARSGKLHCLRYLVEEVALPAV 65 Query: 87 LRKKNGATPFILAAIAGSVKLLKLFLSKG-ADVNECDFYGFTAFMEAAVYGKVKALKFLY 145 R +NGATP AA G + L+ L++G V E D G T AA +G +K+L Sbjct: 66 SRARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVKWLL 125 Query: 146 -KRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRN 204 + GAN + T GA + AA KG + LK+L+ VNA N G Sbjct: 126 YQGGANSAITTDT----------GALPIHYAAAKGDLPSLKLLVGHYPEGVNAQTNNGAT 175 Query: 205 ALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHI 264 L L+ + +E +L+ + AD ++R + G TPL A + H ++ L+ + Sbjct: 176 PLY---LACQEGHLEVTKYLVQECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFADV 232 Query: 265 EINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRN-----YDHSLVKV 319 ++ D DG TA+ A K+ L GA DL + + ++ Sbjct: 233 SFSEQDHDGATAMHFAASRGHTKVLSWLLLHGAEI-SQDLWGGTPLHDAAENGELECCQI 291 Query: 320 LLSHGAKEDFHP----PAEDWKPQSSH 342 L +GA D A D + H Sbjct: 292 LAVNGAGLDVRDHDGYTAADLAEFNGH 318 Score = 150 bits (379), Expect = 2e-36, Method: Composition-based stats. Identities = 71/263 (26%), Positives = 102/263 (38%), Gaps = 19/263 (7%) Query: 27 HLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLL-RHGADP 85 A + +Q LL G +++ G T LH A + D+V+ LL + GA+ Sbjct: 73 TPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVKWLLYQGGANS 132 Query: 86 VLRKKNGATPFILAAIAGSVKLLKLFLSK-GADVNECDFYGFTAFMEAAVYGKVKALKFL 144 + GA P AA G + LKL + VN G T A G ++ K+L Sbjct: 133 AITTDTGALPIHYAAAKGDLPSLKLLVGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYL 192 Query: 145 YKRG-ANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGR 203 + A+ +LR + G T L AA+ GH VL L+ + D+ G Sbjct: 193 VQECSADPHLR----------AQDGMTPLHAAAQMGHNPVLVWLVSFADVSFSEQDHDGA 242 Query: 204 NALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEH 263 A+ A + LL HGA++ + G TPL A E L Q L Sbjct: 243 TAMHFAASRGH----TKVLSWLLLHGAEI-SQDLWGGTPLHDAAENGELECCQIL-AVNG 296 Query: 264 IEINDTDSDGKTALLLAVELKLK 286 ++ D DG TA LA Sbjct: 297 AGLDVRDHDGYTAADLAEFNGHT 319 Score = 145 bits (365), Expect = 7e-35, Method: Composition-based stats. Identities = 64/266 (24%), Positives = 105/266 (39%), Gaps = 17/266 (6%) Query: 19 RRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELL 78 + +L A + D+V+ LL G + + G P+H A ++LL Sbjct: 99 QEKDNSGATVLHLAARFGHPDVVKWLLYQGGANSAITTDTGALPIHYAAAKGDLPSLKLL 158 Query: 79 LRH-GADPVLRKKNGATPFILAAIAGSVKLLKLFLS-KGADVNECDFYGFTAFMEAAVYG 136 + H + NGATP LA G +++ K + AD + G T AA G Sbjct: 159 VGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQECSADPHLRAQDGMTPLHAAAQMG 218 Query: 137 KVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVN 196 L +L A+V+ + + GATA+ AA +GH +VL LL GA+++ Sbjct: 219 HNPVLVWLVSF-ADVSFSEQDHD--------GATAMHFAASRGHTKVLSWLLLH-GAEIS 268 Query: 197 ACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQ 256 D G L A ++ +L +GA ++VR G T LA H + Sbjct: 269 -QDLWGGTPLHDAA----ENGELECCQILAVNGAGLDVRDHDGYTAADLAEFNGHTHCSR 323 Query: 257 RLLEQEHIEINDTDSDGKTALLLAVE 282 L + + + ++ L + Sbjct: 324 YLRTVQTLSLEHRVLSRDQSMDLEAK 349 >6BY9-A nrPDB Length = 328 Score = 231 bits (590), Expect = 7e-61, Method: Composition-based stats. Identities = 68/272 (25%), Positives = 120/272 (44%), Gaps = 20/272 (7%) Query: 19 RRAAVEDNHL--LIKAVQNEDVDLVQQLLEGGANVNFQ-EEEGGWTPLHNAVQMSREDIV 75 + H L + + ++ V +L G + NF+ E + +PLH A + DI Sbjct: 59 EKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDIC 118 Query: 76 ELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVY 135 +L++ GA+ ++ TP + AA ++ +K + GA V+ D G T AA Sbjct: 119 HMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKK 178 Query: 136 GKVKALKFLYKRG-ANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGAD 194 G + +++L G +VN + GG T ++ A E HV+++K+LL + G+D Sbjct: 179 GHYEVVQYLLSNGQMDVNCQDD----------GGWTPMIWATEYKHVDLVKLLLSK-GSD 227 Query: 195 VNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGL 254 +N DN N +H S D I +LL D++ G +PL +A + Sbjct: 228 INIRDNE-ENICLHWAAFSGCVD---IAEILLAAKCDLHAVNIHGDSPLHIAARENRYDC 283 Query: 255 VQRLLEQEHIEINDTDSDGKTALLLAVELKLK 286 V L ++ ++ + +G+T L A Sbjct: 284 VVLFLSRDS-DVTLKNKEGETPLQCASLNSQV 314 Score = 163 bits (413), Expect = 2e-40, Method: Composition-based stats. Identities = 67/300 (22%), Positives = 118/300 (39%), Gaps = 32/300 (10%) Query: 13 PTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSRE 72 PT + E + A+ +E ++ + L+ + + Sbjct: 36 PTPGLSQGPGKETLESALIALDSEKPKKLRFHPKQ---------------LYFSARQGEL 80 Query: 73 DIVELLLRHGADPVLRKKNG--ATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFM 130 V L+L G DP + ++ +P AA AG V + + + GA+++ C T M Sbjct: 81 QKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLM 140 Query: 131 EAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDE 190 EAA ++A+K+L K GA V+ + G+T L AA+KGH EV++ LL Sbjct: 141 EAAENNHLEAVKYLIKAGALVDPKDAE----------GSTCLHLAAKKGHYEVVQYLLSN 190 Query: 191 MGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKK 250 DVN D+ G +I + + + LLL G+D+N+R L A Sbjct: 191 GQMDVNCQDDGGWTPMI----WATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSG 246 Query: 251 HLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARR 310 + + + LL + +++ + G + L +A L R + + Sbjct: 247 CVDIAEILLAAK-CDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPL 305 Score = 129 bits (324), Expect = 5e-30, Method: Composition-based stats. Identities = 45/203 (22%), Positives = 89/203 (43%), Gaps = 18/203 (8%) Query: 129 FMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188 +A G+++ + + G + N + + + + L AAE GHV++ +L+ Sbjct: 71 LYFSARQGELQKVLLMLVDGIDPNFKME--------HQNKRSPLHAAAEAGHVDICHMLV 122 Query: 189 DEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVE 248 GA+++ C R L + + +++ L+ GA V+ + G T L LA + Sbjct: 123 QA-GANIDTCSEDQRTPL----MEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAK 177 Query: 249 KKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTA 308 K H +VQ LL +++N D G T ++ A E K + +LL +G+ + D Sbjct: 178 KGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENI 237 Query: 309 RRNYDH-----SLVKVLLSHGAK 326 ++ + ++LL+ Sbjct: 238 CLHWAAFSGCVDIAEILLAAKCD 260 Score = 125 bits (314), Expect = 7e-29, Method: Composition-based stats. Identities = 59/219 (26%), Positives = 90/219 (41%), Gaps = 19/219 (8%) Query: 96 FILAAIAGSVKLLKLFLSKGADVN--ECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNL 153 +A G ++ + L L G D N + AA G V L + GAN++ Sbjct: 71 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 130 Query: 154 RRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSS 213 + + T LM+AAE H+E +K L+ GA V+ D G L A Sbjct: 131 CSEDQR----------TPLMEAAENNHLEAVKYLIKA-GALVDPKDAEGSTCLHLAAKKG 179 Query: 214 DDSDVEAITHLLLDHG-ADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSD 272 + LL +G DVN + + G TP+I A E KH+ LV+ LL + +IN D++ Sbjct: 180 H----YEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSK-GSDINIRDNE 234 Query: 273 GKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRN 311 L A IAE+L ++ + + Sbjct: 235 ENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLH 273 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 42/156 (26%), Positives = 72/156 (46%), Gaps = 5/156 (3%) Query: 22 AVEDNHLLIKAVQNEDVDLVQQLLEGGA-NVNFQEEEGGWTPLHNAVQMSREDIVELLLR 80 E + L A + ++VQ LL G +VN Q++ GGWTP+ A + D+V+LLL Sbjct: 165 DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDD-GGWTPMIWATEYKHVDLVKLLLS 223 Query: 81 HGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKA 140 G+D +R AA +G V + ++ L+ D++ + +G + AA + Sbjct: 224 KGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDC 283 Query: 141 LKFLYKRGANVNLRRKTKEDQER---LRKGGATALM 173 + R ++V L+ K E + L +AL Sbjct: 284 VVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQ 319 >3B7B-A nrPDB Length = 237 Score = 216 bits (550), Expect = 3e-56, Method: Composition-based stats. Identities = 61/234 (26%), Positives = 105/234 (44%), Gaps = 17/234 (7%) Query: 54 QEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLS 113 E + +PLH A + DI +L++ GA+ ++ TP + AA ++ +K + Sbjct: 6 MEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIK 65 Query: 114 KGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG-ANVNLRRKTKEDQERLRKGGATAL 172 GA V+ D G T AA G + +++L G +VN + GG T + Sbjct: 66 AGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDD----------GGWTPM 115 Query: 173 MDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADV 232 + A E HV+++K+LL + G+D+N DN N +H S D I +LL D+ Sbjct: 116 IWATEYKHVDLVKLLLSK-GSDINIRDNE-ENICLHWAAFSGCVD---IAEILLAAKCDL 170 Query: 233 NVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLK 286 + G +PL +A + V L ++ ++ + +G+T L A Sbjct: 171 HAVNIHGDSPLHIAARENRYDCVVLFLSRDS-DVTLKNKEGETPLQCASLNSQV 223 Score = 201 bits (510), Expect = 1e-51, Method: Composition-based stats. Identities = 61/220 (27%), Positives = 108/220 (49%), Gaps = 17/220 (7%) Query: 28 LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVL 87 L A + VD+ L++ GAN++ E+ TPL A + + + V+ L++ GA Sbjct: 14 PLHAAAEAGHVDICHMLVQAGANIDTCSEDQ-RTPLMEAAENNHLEAVKYLIKAGALVDP 72 Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKG-ADVNECDFYGFTAFMEAAVYGKVKALKFLYK 146 + G+T LAA G ++++ LS G DVN D G+T + A Y V +K L Sbjct: 73 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLS 132 Query: 147 RGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNAL 206 +G+++N+R + L AA G V++ +ILL D++A + G + L Sbjct: 133 KGSDINIRDNEENI----------CLHWAAFSGCVDIAEILLAA-KCDLHAVNIHGDSPL 181 Query: 207 IHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILA 246 +++ ++ + + L L +DV ++ + G+TPL A Sbjct: 182 H---IAARENRYDCVV-LFLSRDSDVTLKNKEGETPLQCA 217 Score = 152 bits (384), Expect = 5e-37, Method: Composition-based stats. Identities = 56/221 (25%), Positives = 94/221 (42%), Gaps = 15/221 (6%) Query: 90 KNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGA 149 +N +P AA AG V + + + GA+++ C T MEAA ++A+K+L K GA Sbjct: 9 QNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGA 68 Query: 150 NVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHA 209 V+ + G+T L AA+KGH EV++ LL DVN D+ G +I Sbjct: 69 LVDPKDAE----------GSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMI-- 116 Query: 210 LLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDT 269 + + + LLL G+D+N+R L A + + + LL + +++ Sbjct: 117 --WATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAK-CDLHAV 173 Query: 270 DSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARR 310 + G + L +A L R + + Sbjct: 174 NIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPL 214 Score = 139 bits (351), Expect = 3e-33, Method: Composition-based stats. Identities = 54/205 (26%), Positives = 89/205 (43%), Gaps = 13/205 (6%) Query: 24 EDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGA 83 + L++A +N ++ V+ L++ GA V+ ++ EG T LH A + ++V+ LL +G Sbjct: 43 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEG-STCLHLAAKKGHYEVVQYLLSNGQ 101 Query: 84 -DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALK 142 D + G TP I A V L+KL LSKG+D+N D AA G V + Sbjct: 102 MDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAE 161 Query: 143 FLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMG 202 L ++ + G + L AA + + + + L +DV + G Sbjct: 162 ILLAAKCDL----------HAVNIHGDSPLHIAARENRYDCVVLFLSR-DSDVTLKNKEG 210 Query: 203 RNALIHALLSSDDSDVEAITHLLLD 227 L A L+S ++ L D Sbjct: 211 ETPLQCASLNSQVWSALQMSKALQD 235 Score = 124 bits (310), Expect = 2e-28, Method: Composition-based stats. Identities = 42/156 (26%), Positives = 72/156 (46%), Gaps = 5/156 (3%) Query: 22 AVEDNHLLIKAVQNEDVDLVQQLLEGGA-NVNFQEEEGGWTPLHNAVQMSREDIVELLLR 80 E + L A + ++VQ LL G +VN Q++ GGWTP+ A + D+V+LLL Sbjct: 74 DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDD-GGWTPMIWATEYKHVDLVKLLLS 132 Query: 81 HGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKA 140 G+D +R AA +G V + ++ L+ D++ + +G + AA + Sbjct: 133 KGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDC 192 Query: 141 LKFLYKRGANVNLRRKTKEDQER---LRKGGATALM 173 + R ++V L+ K E + L +AL Sbjct: 193 VVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQ 228 Score = 122 bits (307), Expect = 4e-28, Method: Composition-based stats. Identities = 41/167 (24%), Positives = 76/167 (45%), Gaps = 10/167 (5%) Query: 165 RKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHL 224 + + L AAE GHV++ +L+ GA+++ C R L + + +++ Sbjct: 8 HQNKRSPLHAAAEAGHVDICHMLVQA-GANIDTCSEDQRTPL----MEAAENNHLEAVKY 62 Query: 225 LLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELK 284 L+ GA V+ + G T L LA +K H +VQ LL +++N D G T ++ A E K Sbjct: 63 LIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYK 122 Query: 285 LKKIAELLCKRGASTDCGDLVMTARRNYDH-----SLVKVLLSHGAK 326 + +LL +G+ + D ++ + ++LL+ Sbjct: 123 HVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCD 169 Score = 118 bits (296), Expect = 8e-27, Method: Composition-based stats. Identities = 52/190 (27%), Positives = 79/190 (41%), Gaps = 17/190 (8%) Query: 123 FYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVE 182 + AA G V L + GAN++ + + T LM+AAE H+E Sbjct: 9 QNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQR----------TPLMEAAENNHLE 58 Query: 183 VLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHG-ADVNVRGERGKT 241 +K L+ GA V+ D G L A + LL +G DVN + + G T Sbjct: 59 AVKYLIKA-GALVDPKDAEGSTCLHLAAKKGH----YEVVQYLLSNGQMDVNCQDDGGWT 113 Query: 242 PLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC 301 P+I A E KH+ LV+ LL + +IN D++ L A IAE+L Sbjct: 114 PMIWATEYKHVDLVKLLLSK-GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHA 172 Query: 302 GDLVMTARRN 311 ++ + + Sbjct: 173 VNIHGDSPLH 182 Score = 65.1 bits (157), Expect = 1e-10, Method: Composition-based stats. Identities = 29/124 (23%), Positives = 53/124 (42%), Gaps = 13/124 (10%) Query: 230 ADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIA 289 + + + ++PL A E H+ + +L Q I+ D +T L+ A E + Sbjct: 2 MNFKMEHQNKRSPLHAAAEAGHVDI-CHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAV 60 Query: 290 ELLCKRGASTDCGD------LVMTARRNYDHSLVKVLLSHG-----AKEDFHPPAEDWKP 338 + L K GA D D L + A++ + + +V+ LLS+G ++D W Sbjct: 61 KYLIKAGALVDPKDAEGSTCLHLAAKKGH-YEVVQYLLSNGQMDVNCQDDGGWTPMIWAT 119 Query: 339 QSSH 342 + H Sbjct: 120 EYKH 123 >5AQA-A nrPDB Length = 418 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 60/177 (33%), Positives = 88/177 (49%), Gaps = 19/177 (10%) Query: 14 TSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSRED 73 S GR+ L++A + D V+ L+ GA+VN + G TPLH A + Sbjct: 11 GSDLGRK--------LLEAARAGQDDEVRILMANGADVNAADNTGT-TPLHLAAYSGHLE 61 Query: 74 IVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAA 133 IVE+LL+HGAD G TP LAA G ++++++ L GADVN D G T AA Sbjct: 62 IVEVLLKHGADVDASDVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAA 121 Query: 134 VYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDE 190 +G + ++ L K GA+V+ + K G L AA++GH E+ L+ Sbjct: 122 KWGYKEIVEVLLKAGADVDAQDKF----------GKRPLWLAADQGHAEIAAKLVAA 168 Score = 168 bits (425), Expect = 9e-42, Method: Composition-based stats. Identities = 52/196 (26%), Positives = 87/196 (44%), Gaps = 11/196 (5%) Query: 63 LHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECD 122 L A + ++D V +L+ +GAD G TP LAA +G ++++++ L GADV+ D Sbjct: 18 LLEAARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASD 77 Query: 123 FYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVE 182 +G+T AA +G ++ ++ L K GA+VN G T L AA+ G+ E Sbjct: 78 VFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSD----------GMTPLHLAAKWGYKE 127 Query: 183 VLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTP 242 ++++LL GADV+A D G+ L A + L Sbjct: 128 IVEVLLKA-GADVDAQDKFGKRPLWLAADQGHAEIAAKLVAARLKARVGYIELDLNSGKI 186 Query: 243 LILAVEKKHLGLVQRL 258 L ++ ++ Sbjct: 187 LESVRSEERFPMMSTF 202 Score = 161 bits (407), Expect = 1e-39, Method: Composition-based stats. Identities = 64/185 (34%), Positives = 84/185 (45%), Gaps = 33/185 (17%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 L++AA G + ++IL+ GADVNA DN G L A S I +LL HGAD Sbjct: 18 LLEAARAGQDDEVRILMAN-GADVNAADNTGTTPLHLAAYSGHLE----IVEVLLKHGAD 72 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAEL 291 V+ G TPL LA HL +V+ LL + ++N DSDG T L LA + K+I E+ Sbjct: 73 VDASDVFGYTPLHLAAYWGHLEIVEVLL-KNGADVNAMDSDGMTPLHLAAKWGYKEIVEV 131 Query: 292 LCKRGASTDCGDLVM------------------------TARRNY---DHSLVKVLLSHG 324 L K GA D D AR Y D + K+L S Sbjct: 132 LLKAGADVDAQDKFGKRPLWLAADQGHAEIAAKLVAARLKARVGYIELDLNSGKILESVR 191 Query: 325 AKEDF 329 ++E F Sbjct: 192 SEERF 196 Score = 136 bits (342), Expect = 4e-32, Method: Composition-based stats. Identities = 47/167 (28%), Positives = 74/167 (44%), Gaps = 12/167 (7%) Query: 210 LLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDT 269 LL + + + +L+ +GADVN G TPL LA HL +V+ LL + +++ + Sbjct: 18 LLEAARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLL-KHGADVDAS 76 Query: 270 DSDGKTALLLAVELKLKKIAELLCKRGASTDCGD------LVMTARRNYDHSLVKVLLSH 323 D G T L LA +I E+L K GA + D L + A+ Y +V+VLL Sbjct: 77 DVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGY-KEIVEVLLKA 135 Query: 324 GAKED----FHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFID 366 GA D F H A K + + +G ++ ++ Sbjct: 136 GADVDAQDKFGKRPLWLAADQGHAEIAAKLVAARLKARVGYIELDLN 182 >5AQ9-A nrPDB Length = 422 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 61/181 (33%), Positives = 89/181 (49%), Gaps = 19/181 (10%) Query: 14 TSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSRED 73 S GR+ L++A + D V+ L+ GA+VN + G TPLH A + Sbjct: 11 GSDLGRK--------LLEAARAGQDDEVRILMANGADVNAADNTGT-TPLHLAAYSGHLE 61 Query: 74 IVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAA 133 IVE+LL+HGAD G TP LAA G ++++++ L GADVN D G T AA Sbjct: 62 IVEVLLKHGADVDASDVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAA 121 Query: 134 VYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGA 193 +G ++ ++ L K GA+VN + K G T A + G+ +V +L A Sbjct: 122 KWGYLEIVEVLLKHGADVNAQDKF----------GKTPFDLADDNGNDDVGTLLQVAAAA 171 Query: 194 D 194 D Sbjct: 172 D 172 Score = 167 bits (424), Expect = 1e-41, Method: Composition-based stats. Identities = 66/204 (32%), Positives = 94/204 (46%), Gaps = 24/204 (11%) Query: 129 FMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188 +EAA G+ ++ L GA+VN T G T L AA GH+E++++LL Sbjct: 18 LLEAARAGQDDEVRILMANGADVNAADNT----------GTTPLHLAAYSGHLEIVEVLL 67 Query: 189 DEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVE 248 GADV+A D G L A I +LL +GADVN G TPL LA + Sbjct: 68 KH-GADVDASDVFGYTPLHLAAYWGHLE----IVEVLLKNGADVNAMDSDGMTPLHLAAK 122 Query: 249 KKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTA 308 +L +V+ LL + ++N D GKT LA + + LL A+ + A Sbjct: 123 WGYLEIVEVLL-KHGADVNAQDKFGKTPFDLADDNGNDDVGTLLQVAAAADQ-----LGA 176 Query: 309 RRNY---DHSLVKVLLSHGAKEDF 329 R Y D + K+L S ++E F Sbjct: 177 RVGYIELDLNSGKILESFRSEERF 200 Score = 141 bits (355), Expect = 1e-33, Method: Composition-based stats. Identities = 44/149 (29%), Positives = 68/149 (45%), Gaps = 12/149 (8%) Query: 210 LLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDT 269 LL + + + +L+ +GADVN G TPL LA HL +V+ LL + +++ + Sbjct: 18 LLEAARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLL-KHGADVDAS 76 Query: 270 DSDGKTALLLAVELKLKKIAELLCKRGASTDCGD------LVMTARRNYDHSLVKVLLSH 323 D G T L LA +I E+L K GA + D L + A+ Y +V+VLL H Sbjct: 77 DVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGY-LEIVEVLLKH 135 Query: 324 G----AKEDFHPPAEDWKPQSSHWGAALK 348 G A++ F D + + Sbjct: 136 GADVNAQDKFGKTPFDLADDNGNDDVGTL 164 >2DWZ-A nrPDB Length = 231 Score = 207 bits (526), Expect = 2e-53, Method: Composition-based stats. Identities = 67/235 (28%), Positives = 108/235 (45%), Gaps = 18/235 (7%) Query: 33 VQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNG 92 + +D +++ + ++ + ++ T LH A +IVE LL+ G + G Sbjct: 14 AYSGKLDELKERILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73 Query: 93 ATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVN 152 +P +AA AG +++K L KGA VN + G T AA + + L + GAN + Sbjct: 74 WSPLHIAASAGRDEIVKALLVKGAHVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133 Query: 153 LRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLS 212 + ATA+ AA KG+++++ ILL A N D G L L+ Sbjct: 134 AKDHYD----------ATAMHRAAAKGNLKMVHILL-FYKASTNIQDTEGNTPLH---LA 179 Query: 213 SDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLV-QRLLEQEHIEI 266 D+ VE L+ GA + + + KTPL +A K LGL+ +RL E E + Sbjct: 180 CDEERVEE-AKFLVTQGASIYIENKEEKTPLQVA--KGGLGLILKRLAEGEEASM 231 Score = 148 bits (373), Expect = 9e-36, Method: Composition-based stats. Identities = 57/228 (25%), Positives = 95/228 (41%), Gaps = 17/228 (7%) Query: 100 AIAGSV-KLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTK 158 A +G + +L + L+ + D TA A G + ++FL + G VN + Sbjct: 14 AYSGKLDELKERILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD-- 71 Query: 159 EDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDV 218 G + L AA G E++K LL + GA VNA + G L +A + Sbjct: 72 --------AGWSPLHIAASAGRDEIVKALLVK-GAHVNAVNQNGCTPLHYAAS----KNR 118 Query: 219 EAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALL 278 I +LL+ GA+ + + T + A K +L +V LL N D++G T L Sbjct: 119 HEIAVMLLEGGANPDAKDHYDATAMHRAAAKGNLKMVHILL-FYKASTNIQDTEGNTPLH 177 Query: 279 LAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAK 326 LA + + + A+ L +GAS + + ++L A+ Sbjct: 178 LACDEERVEEAKFLVTQGASIYIENKEEKTPLQVAKGGLGLILKRLAE 225 Score = 75.9 bits (185), Expect = 6e-14, Method: Composition-based stats. Identities = 26/118 (22%), Positives = 47/118 (39%), Gaps = 6/118 (5%) Query: 216 SDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKT 275 ++ + +L + + +T L A H +V+ LL Q + +ND D G + Sbjct: 17 GKLDELKERILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL-QLGVPVNDKDDAGWS 75 Query: 276 ALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYD-----HSLVKVLLSHGAKED 328 L +A +I + L +GA + + +Y H + +LL GA D Sbjct: 76 PLHIAASAGRDEIVKALLVKGAHVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133 >4JXF-A nrPDB Length = 266 Score = 205 bits (522), Expect = 5e-53, Method: Composition-based stats. Identities = 56/263 (21%), Positives = 99/263 (37%), Gaps = 48/263 (18%) Query: 366 DEKYKIADTSEGGIYLGFYEKQ------EVAVKTFCEGS-------PRAQREVSCLQSSR 412 E +K+ + G + G Y + EVA+K + + R Q EV + Sbjct: 6 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVK-IHCQL 64 Query: 413 ENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAV 472 ++ ++ Y ++++ + +C ++ + V+ + AR+ + I + Sbjct: 65 KHPSILELYNYFEDSNYVYLVLEMCHNG---EMNRYLKNRVKPFSENEARHFMHQIITGM 121 Query: 473 QELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI----------KWAGDPQEV----- 517 LH S G H+DL N+L+ +ADF + G P + Sbjct: 122 LYLH-SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIA 180 Query: 518 -------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDE-------ETKDLI 563 + D+ LG + Y + G F+ ++ V L+ E E KDLI Sbjct: 181 TRSAHGLESDVWSLGC-MFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLI 239 Query: 564 HRLFHPGEHVRDCLSDLLGHPFF 586 H+L R LS +L HPF Sbjct: 240 HQLLRRNPADRLSLSSVLDHPFM 262 >4NIK-A nrPDB Length = 230 Score = 204 bits (519), Expect = 1e-52, Method: Composition-based stats. Identities = 63/223 (28%), Positives = 104/223 (46%), Gaps = 17/223 (7%) Query: 33 VQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNG 92 + ++ +++ + ++ + ++ T LH A +IVE LL+ G + G Sbjct: 18 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 77 Query: 93 ATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVN 152 +P +AA AG +++K L KGA VN + G T AA + + L + GAN + Sbjct: 78 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 137 Query: 153 LRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLS 212 + + ATA+ AA KG+++++ ILL A N D G L L+ Sbjct: 138 AKDHYE----------ATAMHRAAAKGNLKMIHILL-YYKASTNIQDTEGNTPLH---LA 183 Query: 213 SDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLV 255 D+ VE LL+ GA + + + KTPL +A K LGL+ Sbjct: 184 CDEERVEE-AKLLVSQGASIYIENKEEKTPLQVA--KGGLGLI 223 Score = 149 bits (377), Expect = 3e-36, Method: Composition-based stats. Identities = 56/205 (27%), Positives = 90/205 (43%), Gaps = 17/205 (8%) Query: 100 AIAGSVKLLK-LFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTK 158 A +G ++ LK L+ + D TA A G + ++FL + G VN + Sbjct: 18 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD-- 75 Query: 159 EDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDV 218 G + L AA G E++K LL + GA VNA + G L +A + Sbjct: 76 --------AGWSPLHIAASAGRDEIVKALLGK-GAQVNAVNQNGCTPLHYAAS----KNR 122 Query: 219 EAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALL 278 I +LL+ GA+ + + T + A K +L ++ LL N D++G T L Sbjct: 123 HEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILL-YYKASTNIQDTEGNTPLH 181 Query: 279 LAVELKLKKIAELLCKRGASTDCGD 303 LA + + + A+LL +GAS + Sbjct: 182 LACDEERVEEAKLLVSQGASIYIEN 206 Score = 124 bits (310), Expect = 2e-28, Method: Composition-based stats. Identities = 45/152 (29%), Positives = 72/152 (47%), Gaps = 1/152 (0%) Query: 28 LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVL 87 L A ++V+ LL GA VN + G TPLH A +R +I +LL GA+P Sbjct: 80 PLHIAASAGRDEIVKALLGKGAQVNAV-NQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 138 Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147 + AT AA G++K++ + L A N D G T A +V+ K L + Sbjct: 139 KDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQ 198 Query: 148 GANVNLRRKTKEDQERLRKGGATALMDAAEKG 179 GA++ + K ++ ++ KGG ++ +G Sbjct: 199 GASIYIENKEEKTPLQVAKGGLGLILKRMVEG 230 Score = 77.0 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 32/143 (22%), Positives = 57/143 (39%), Gaps = 9/143 (6%) Query: 216 SDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKT 275 +E + +L + + +T L A H +V+ LL Q + +ND D G + Sbjct: 21 GKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL-QLGVPVNDKDDAGWS 79 Query: 276 ALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYD-----HSLVKVLLSHGAKEDFH 330 L +A +I + L +GA + + +Y H + +LL GA D Sbjct: 80 PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD-- 137 Query: 331 PPAEDWKPQSSHWGAALKDLHRI 353 + ++ + H AA +L I Sbjct: 138 -AKDHYEATAMHRAAAKGNLKMI 159 >3DB8-A nrPDB Length = 317 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 54/258 (20%), Positives = 103/258 (39%), Gaps = 44/258 (17%) Query: 369 YKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVS---CLQSSRENSHLVTFYGSES 425 Y+I D ++ G + + +K P + ++S + S +N H+V F+G Sbjct: 59 YEITDMDTKEVFAGKVVPKSMLLK------PHQKEKMSTEIAIHKSLDNPHVVGFHGFFE 112 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 ++V + +C + + L++H+ E + AR + + VQ LH + H+D Sbjct: 113 DDDFVYVVLEICRR--RSLLELHKRRKAVTEPE--ARYFMRQTIQGVQYLH-NNRVIHRD 167 Query: 486 LQPQNILIDSKKAAHLADFDKSIK----------WAGDPQEV------------KRDLED 523 L+ N+ ++ + DF + K G P + + D+ Sbjct: 168 LKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCKKGHSFEVDIWS 227 Query: 524 LGRLVLYVVKKGSISFED-------LKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDC 576 LG +LY + G FE ++ + NE V + LI R+ H +R Sbjct: 228 LGC-ILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALIRRMLHADPTLRPS 286 Query: 577 LSDLLGHPFFWTWESRYR 594 +++LL FF + + R Sbjct: 287 VAELLTDEFFTSGYAPMR 304 >5AQB-A nrPDB Length = 428 Score = 203 bits (516), Expect = 3e-52, Method: Composition-based stats. Identities = 58/174 (33%), Positives = 92/174 (52%), Gaps = 20/174 (11%) Query: 14 TSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSRED 73 S G++ L++A + D + L+ GA+VN +E G WTPLH A + Sbjct: 11 GSDLGKK--------LLEAARAGQDDECRILMANGADVNALDEVG-WTPLHLAAW-GHLE 60 Query: 74 IVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAA 133 IVE LL++GAD +G TP LAA +G ++++++ L GADVN D GFT AA Sbjct: 61 IVECLLKNGADVNAADIDGYTPLHLAAFSGHLEIVEVLLKYGADVNADDQAGFTPLHLAA 120 Query: 134 VYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKIL 187 ++G ++ ++ L K GA+VN + K G T A + G+ ++ ++L Sbjct: 121 IFGHLEIVEVLLKNGADVNAQDKF----------GKTPRDLAIDNGNEDIAEVL 164 Score = 167 bits (422), Expect = 2e-41, Method: Composition-based stats. Identities = 59/192 (30%), Positives = 90/192 (46%), Gaps = 20/192 (10%) Query: 63 LHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECD 122 L A + ++D +L+ +GAD + G TP LAA G +++++ L GADVN D Sbjct: 18 LLEAARAGQDDECRILMANGADVNALDEVGWTPLHLAA-WGHLEIVECLLKNGADVNAAD 76 Query: 123 FYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVE 182 G+T AA G ++ ++ L K GA+VN + G T L AA GH+E Sbjct: 77 IDGYTPLHLAAFSGHLEIVEVLLKYGADVNADD----------QAGFTPLHLAAIFGHLE 126 Query: 183 VLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTP 242 ++++LL GADVNA D G+ A+ D+ E I +L V V+ Sbjct: 127 IVEVLLKN-GADVNAQDKFGKTPRDLAI----DNGNEDIAEVLGKAATLVKVKDAAD--- 178 Query: 243 LILAVEKKHLGL 254 L ++ L Sbjct: 179 -QLGARVGYIEL 189 Score = 146 bits (369), Expect = 3e-35, Method: Composition-based stats. Identities = 54/176 (30%), Positives = 75/176 (42%), Gaps = 12/176 (6%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 L++AA G + +IL+ GADVNA D +G L H I LL +GAD Sbjct: 18 LLEAARAGQDDECRILMAN-GADVNALDEVGWTPL-HLAAWGHLE----IVECLLKNGAD 71 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAEL 291 VN G TPL LA HL +V+ LL + ++N D G T L LA +I E+ Sbjct: 72 VNAADIDGYTPLHLAAFSGHLEIVEVLL-KYGADVNADDQAGFTPLHLAAIFGHLEIVEV 130 Query: 292 LCKRGASTDCGDLVMTARR-----NYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSH 342 L K GA + D R N + + +VL A+ + + Sbjct: 131 LLKNGADVNAQDKFGKTPRDLAIDNGNEDIAEVLGKAATLVKVKDAADQLGARVGY 186 Score = 133 bits (335), Expect = 2e-31, Method: Composition-based stats. Identities = 45/150 (30%), Positives = 67/150 (44%), Gaps = 11/150 (7%) Query: 206 LIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIE 265 L LL + + + +L+ +GADVN E G TPL LA HL +V+ LL + + Sbjct: 14 LGKKLLEAARAGQDDECRILMANGADVNALDEVGWTPLHLAA-WGHLEIVECLL-KNGAD 71 Query: 266 INDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYD-----HSLVKVL 320 +N D DG T L LA +I E+L K GA + D + +V+VL Sbjct: 72 VNAADIDGYTPLHLAAFSGHLEIVEVLLKYGADVNADDQAGFTPLHLAAIFGHLEIVEVL 131 Query: 321 LSHG----AKEDFHPPAEDWKPQSSHWGAA 346 L +G A++ F D + + A Sbjct: 132 LKNGADVNAQDKFGKTPRDLAIDNGNEDIA 161 Score = 104 bits (260), Expect = 1e-22, Method: Composition-based stats. Identities = 33/103 (32%), Positives = 55/103 (53%), Gaps = 1/103 (0%) Query: 21 AAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLR 80 A ++ L A + +++V+ LL+ GA+VN +++ G+TPLH A +IVE+LL+ Sbjct: 75 ADIDGYTPLHLAAFSGHLEIVEVLLKYGADVNA-DDQAGFTPLHLAAIFGHLEIVEVLLK 133 Query: 81 HGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDF 123 +GAD + K G TP LA G+ + ++ V D Sbjct: 134 NGADVNAQDKFGKTPRDLAIDNGNEDIAEVLGKAATLVKVKDA 176 >5AQ7-A nrPDB Length = 418 Score = 203 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 58/177 (32%), Positives = 89/177 (50%), Gaps = 19/177 (10%) Query: 14 TSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSRED 73 S G++ L++A + D V+ LL GA+VN +E G +TPLH A Sbjct: 11 GSDLGKK--------LLEAARAGQDDEVRILLANGADVNTADETG-FTPLHLAAWEGHLG 61 Query: 74 IVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAA 133 IVE+LL++GAD + G TP LAA G ++++++ L GA VN D G AA Sbjct: 62 IVEVLLKNGADVNANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAA 121 Query: 134 VYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDE 190 ++G + ++ L K GA+V+ + K G L AA++GH E+ L+ Sbjct: 122 MWGYKEIVEVLLKAGADVDAQDKF----------GKRPLWLAADQGHAEIAAKLVAA 168 Score = 147 bits (370), Expect = 2e-35, Method: Composition-based stats. Identities = 62/204 (30%), Positives = 91/204 (44%), Gaps = 28/204 (13%) Query: 129 FMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188 +EAA G+ ++ L GA+VN +T G T L AA +GH+ ++++LL Sbjct: 18 LLEAARAGQDDEVRILLANGADVNTADET----------GFTPLHLAAWEGHLGIVEVLL 67 Query: 189 DEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVE 248 GADVNA D G L A + I +LL +GA VN G PL LA Sbjct: 68 KN-GADVNANDERGHTPLHLAAYTGHLE----IVEVLLKNGAGVNATDVIGTAPLHLAAM 122 Query: 249 KKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTA 308 + +V+ LL + +++ D GK L LA + +IA L + A Sbjct: 123 WGYKEIVEVLL-KAGADVDAQDKFGKRPLWLAADQGHAEIAAKLVAA---------RLKA 172 Query: 309 RRNY---DHSLVKVLLSHGAKEDF 329 R Y D + K+L S ++E F Sbjct: 173 RVGYIELDLNSGKILESVRSEERF 196 Score = 142 bits (357), Expect = 6e-34, Method: Composition-based stats. Identities = 51/170 (30%), Positives = 77/170 (45%), Gaps = 10/170 (5%) Query: 206 LIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIE 265 L LL + + + +LL +GADVN E G TPL LA + HLG+V+ LL + + Sbjct: 14 LGKKLLEAARAGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLL-KNGAD 72 Query: 266 INDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYD-----HSLVKVL 320 +N D G T L LA +I E+L K GA + D++ TA + +V+VL Sbjct: 73 VNANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGYKEIVEVL 132 Query: 321 LSHGAKED----FHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFID 366 L GA D F H A K + + +G ++ ++ Sbjct: 133 LKAGADVDAQDKFGKRPLWLAADQGHAEIAAKLVAARLKARVGYIELDLN 182 >3M42-A nrPDB Length = 299 Score = 203 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 59/253 (23%), Positives = 106/253 (41%), Gaps = 32/253 (12%) Query: 362 KFFIDEKYKIADTSEG----GIYLGFYEK--QEVAVKTFCEGSPRAQREVSCLQSSRENS 415 K I + YK+ G G L + K QE + P+A+REV + + Sbjct: 12 KNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCP 71 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENE--EDEFARNVLSSIFKAVQ 473 H+V + C+ + + L+ R +D ++ + A ++ SI +A+Q Sbjct: 72 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 131 Query: 474 ELHLSCGYTHQDLQPQNILIDSKKA---AHLADFDKSIKWAGDPQEVKRDLEDLGRLVLY 530 LH S H+D++P+N+L SK+ L DF + + G+ + D+ LG +++Y Sbjct: 132 YLH-SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGEKYDKSCDMWSLG-VIMY 189 Query: 531 VVKKGSISFED---------LKAQ--------SNEEVVQLSPDEETKDLIHRLFHPGEHV 573 ++ G F +K + N E ++S EE K LI L Sbjct: 190 ILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS--EEVKMLIRNLLKTEPTQ 247 Query: 574 RDCLSDLLGHPFF 586 R +++ + HP+ Sbjct: 248 RMTITEFMNHPWI 260 >6FES-A nrPDB Length = 367 Score = 202 bits (513), Expect = 6e-52, Method: Composition-based stats. Identities = 60/182 (32%), Positives = 95/182 (52%), Gaps = 13/182 (7%) Query: 12 GPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSR 71 GP S G++ L++A + D V+ LL GA+VN +E G +TPLH A Sbjct: 1 GPGSDLGKK--------LLEAARAGQDDEVRILLANGADVNTADETG-FTPLHLAAWEGH 51 Query: 72 EDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFME 131 IVE+LL++GAD + G TP LAA G ++++++ L GA VN D G Sbjct: 52 LGIVEVLLKNGADVNANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHL 111 Query: 132 AAVYGKVKALKFLYKRGANVNLRRKTKEDQERL-RKGGATALMDAAEKGHVEVLKILLDE 190 AA++G + ++ L K GA+ + K + E L R G ++ A K E+++ ++DE Sbjct: 112 AAMWGHEEIVEVLLKNGADARAQDKFGKTPEDLARDNGYESVARLARK---EIIRAVVDE 168 Query: 191 MG 192 + Sbjct: 169 LK 170 Score = 175 bits (443), Expect = 7e-44, Method: Composition-based stats. Identities = 55/169 (32%), Positives = 83/169 (49%), Gaps = 10/169 (5%) Query: 206 LIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIE 265 L LL + + + +LL +GADVN E G TPL LA + HLG+V+ LL + + Sbjct: 6 LGKKLLEAARAGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLL-KNGAD 64 Query: 266 INDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRN----YDH-SLVKVL 320 +N D G T L LA +I E+L K GA + D++ TA + + H +V+VL Sbjct: 65 VNANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGHEEIVEVL 124 Query: 321 LSHG----AKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFI 365 L +G A++ F ED + + A I R ++ +LK I Sbjct: 125 LKNGADARAQDKFGKTPEDLARDNGYESVARLARKEIIRAVVDELKELI 173 >6MWQ-A nrPDB Length = 493 Score = 201 bits (511), Expect = 9e-52, Method: Composition-based stats. Identities = 68/242 (28%), Positives = 108/242 (44%), Gaps = 24/242 (9%) Query: 14 TSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSRED 73 S G++ L++A + D V+ L+ GA+VN + G TPLH A Q + Sbjct: 2 GSDLGKK--------LLEAARAGQDDEVRILMANGADVNALDRFG-LTPLHLAAQRGHLE 52 Query: 74 IVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAA 133 IVE+LL+ GAD G TP LAA AG ++++++ L GADVN D G T A Sbjct: 53 IVEVLLKCGADVNAADLWGQTPLHLAATAGHLEIVEVLLKYGADVNALDLIGKTPLHLTA 112 Query: 134 VYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGA 193 + G ++ ++ L K GA+VN + K G TA + + G+ ++ +IL Sbjct: 113 IDGHLEIVEVLLKHGADVNAQDKF----------GKTAFDISIDNGNEDLAEILQK---- 158 Query: 194 DVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLG 253 +N D R + + D +I L G + R L+L + + Sbjct: 159 -LNLSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNP 217 Query: 254 LV 255 + Sbjct: 218 CI 219 Score = 161 bits (406), Expect = 2e-39, Method: Composition-based stats. Identities = 71/249 (28%), Positives = 115/249 (46%), Gaps = 25/249 (10%) Query: 96 FILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR 155 + AA AG +++ ++ GADVN D +G T AA G ++ ++ L K GA+VN Sbjct: 9 LLEAARAGQDDEVRILMANGADVNALDRFGLTPLHLAAQRGHLEIVEVLLKCGADVNAAD 68 Query: 156 KTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDD 215 G T L AA GH+E++++LL + GADVNA D +G+ L + Sbjct: 69 ----------LWGQTPLHLAATAGHLEIVEVLL-KYGADVNALDLIGKTPLHLTAIDGHL 117 Query: 216 SDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKT 275 I +LL HGADVN + + GKT ++++ + L + L + +I Sbjct: 118 E----IVEVLLKHGADVNAQDKFGKTAFDISIDNGNEDLAEILQKLNLSDI-AHRIVAPG 172 Query: 276 ALLLAVELKLKKIAELLCKRGASTDCGD------LVMTARRNYDHSLVKVLLSHGAKEDF 329 +LA + IA+ L G + L++TA + + V+L H E Sbjct: 173 KGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFH---ETL 229 Query: 330 HPPAEDWKP 338 + A+D +P Sbjct: 230 YQKADDGRP 238 Score = 144 bits (363), Expect = 1e-34, Method: Composition-based stats. Identities = 46/150 (30%), Positives = 71/150 (47%), Gaps = 10/150 (6%) Query: 206 LIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIE 265 L LL + + + +L+ +GADVN G TPL LA ++ HL +V+ LL+ + Sbjct: 5 LGKKLLEAARAGQDDEVRILMANGADVNALDRFGLTPLHLAAQRGHLEIVEVLLKC-GAD 63 Query: 266 INDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYD-----HSLVKVL 320 +N D G+T L LA +I E+L K GA + DL+ + +V+VL Sbjct: 64 VNAADLWGQTPLHLAATAGHLEIVEVLLKYGADVNALDLIGKTPLHLTAIDGHLEIVEVL 123 Query: 321 LSHG----AKEDFHPPAEDWKPQSSHWGAA 346 L HG A++ F A D + + A Sbjct: 124 LKHGADVNAQDKFGKTAFDISIDNGNEDLA 153 >3VN9-A nrPDB Length = 340 Score = 198 bits (504), Expect = 7e-51, Method: Composition-based stats. Identities = 56/264 (21%), Positives = 97/264 (36%), Gaps = 42/264 (15%) Query: 370 KIADTSEGGIYLGFYEK--QEVAVKTFC-----EGSPRAQREVSCLQSSRENSHLVTFYG 422 ++ + G + + Q +AVK + R ++ + + VTFYG Sbjct: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 Query: 423 SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYT 482 + G +++C+ L + +L+ + ED + + SI KA++ LH Sbjct: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK-IAVSIVKALEHLHSKLSVI 176 Query: 483 HQDLQPQNILIDSKKAAHLADFDKS----------IKWAGDP---------------QEV 517 H+D++P N+LI++ + DF S I P V Sbjct: 177 HRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSV 236 Query: 518 KRDLEDLGRLVL------YVVKKGSISFEDLKAQSNEEVVQLSPDE---ETKDLIHRLFH 568 K D+ LG ++ + F+ LK E QL D+ E D + Sbjct: 237 KSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLK 296 Query: 569 PGEHVRDCLSDLLGHPFFWTWESR 592 R +L+ HPFF ES+ Sbjct: 297 KNSKERPTYPELMQHPFFTLHESK 320 >3FME-A nrPDB Length = 290 Score = 198 bits (504), Expect = 7e-51, Method: Composition-based stats. Identities = 56/264 (21%), Positives = 97/264 (36%), Gaps = 42/264 (15%) Query: 370 KIADTSEGGIYLGFYEK--QEVAVKTFC-----EGSPRAQREVSCLQSSRENSHLVTFYG 422 ++ + G + + Q +AVK + R ++ + + VTFYG Sbjct: 14 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 73 Query: 423 SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYT 482 + G +++C+ L + +L+ + ED + + SI KA++ LH Sbjct: 74 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK-IAVSIVKALEHLHSKLSVI 132 Query: 483 HQDLQPQNILIDSKKAAHLADFDKS----------IKWAGDP---------------QEV 517 H+D++P N+LI++ + DF S I P V Sbjct: 133 HRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERINPELNQKGYSV 192 Query: 518 KRDLEDLGRLVL------YVVKKGSISFEDLKAQSNEEVVQLSPDE---ETKDLIHRLFH 568 K D+ LG ++ + F+ LK E QL D+ E D + Sbjct: 193 KSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLK 252 Query: 569 PGEHVRDCLSDLLGHPFFWTWESR 592 R +L+ HPFF ES+ Sbjct: 253 KNSKERPTYPELMQHPFFTLHESK 276 >3ALO-A nrPDB Length = 327 Score = 198 bits (502), Expect = 9e-51, Method: Composition-based stats. Identities = 56/269 (20%), Positives = 99/269 (36%), Gaps = 48/269 (17%) Query: 370 KIADTSEGGIYLGFYEK--QEVAVKTFCEGSPRAQR-----EVSCLQSSRENSHLVTFYG 422 +I + G + ++ Q +AVK ++ ++ + S + ++V FYG Sbjct: 29 EIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYG 88 Query: 423 SESHRGHLFVCVTLCEQTLEACLD-VHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 + G ++C+ L + + V+ D E+ + L+ KA+ L + Sbjct: 89 ALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLA-TVKALNHLKENLKI 147 Query: 482 THQDLQPQNILIDSKKAAHLADFDKS----------IKWAGDP---------------QE 516 H+D++P NIL+D L DF S P + Sbjct: 148 IHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYD 207 Query: 517 VKRDLEDLGRLVLYVVKKGSIS-------FEDLKAQSNEEVVQLSPDEETK------DLI 563 V+ D+ LG + LY + G F+ L + QLS EE + + + Sbjct: 208 VRSDVWSLG-ITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFV 266 Query: 564 HRLFHPGEHVRDCLSDLLGHPFFWTWESR 592 + E R +LL HPF +E R Sbjct: 267 NLCLTKDESKRPKYKELLKHPFILMYEER 295 >1WG0-A nrPDB Length = 243 Score = 195 bits (495), Expect = 7e-50, Method: Composition-based stats. Identities = 54/230 (23%), Positives = 100/230 (43%), Gaps = 18/230 (7%) Query: 25 DNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGAD 84 N+ L +A + VQ+LL ++ Q+++ G PLH +V +I LL + Sbjct: 2 SNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMEN 61 Query: 85 PVL---RKKNGATPFILAAIAGSVKLLKLFLSKG--ADVNECDFYGFTAFMEAAVYGKVK 139 L +G TPF +A G+++++K + D+N+ G T A + Sbjct: 62 VNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFE 121 Query: 140 ALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACD 199 +FL + GA+V ++ K + L AA G ++++++L + VN D Sbjct: 122 VSQFLIENGASVRIKDKFNQI----------PLHRAASVGSLKLIELLCGLGKSAVNWQD 171 Query: 200 NMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEK 249 G L HAL +A L+ +GA+ ++ +G +A+ + Sbjct: 172 KQGWTPLFHALAEGHG---DAAVLLVEKYGAEYDLVDNKGAKAEDVALNE 218 Score = 122 bits (305), Expect = 7e-28, Method: Composition-based stats. Identities = 52/212 (24%), Positives = 81/212 (38%), Gaps = 14/212 (6%) Query: 95 PFILAAIAGSVKLLKLFL-SKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNL 153 P A + ++ L SK + + + D G + + + FL + NVNL Sbjct: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 Query: 154 RRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDE-MGADVNACDNMGRNALIHALLS 212 G T A G++EV+K L D + D+N N G L A+ Sbjct: 65 DD-------YPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAV-- 115 Query: 213 SDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSD 272 ++ L+++GA V ++ + + PL A L L++ L +N D Sbjct: 116 --GKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQ 173 Query: 273 GKTALLLAVELKLKKIAELLC-KRGASTDCGD 303 G T L A+ A LL K GA D D Sbjct: 174 GWTPLFHALAEGHGDAAVLLVEKYGAEYDLVD 205 Score = 107 bits (267), Expect = 2e-23, Method: Composition-based stats. Identities = 49/196 (25%), Positives = 80/196 (40%), Gaps = 15/196 (7%) Query: 15 SSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQE--EEGGWTPLHNAVQMSRE 72 S + + L +V + ++ LL NVN + ++ GWTP H A + Sbjct: 26 PSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNL 85 Query: 73 DIVELLLRHGADPVLRK--KNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFM 130 ++V+ L P L K G T LA ++ + + GA V D + Sbjct: 86 EVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLH 145 Query: 131 EAAVYGKVKALKFLYKRGAN-VNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLD 189 AA G +K ++ L G + VN + K G T L A +GH + +L++ Sbjct: 146 RAASVGSLKLIELLCGLGKSAVNWQDK----------QGWTPLFHALAEGHGDAAVLLVE 195 Query: 190 EMGADVNACDNMGRNA 205 + GA+ + DN G A Sbjct: 196 KYGAEYDLVDNKGAKA 211 Score = 71.7 bits (174), Expect = 1e-12, Method: Composition-based stats. Identities = 37/155 (23%), Positives = 62/155 (40%), Gaps = 8/155 (5%) Query: 171 ALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGA 230 L A + ++ LL + + D GR L S IT LL Sbjct: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLH----WSVSFQAHEITSFLLSKME 60 Query: 231 DVNV---RGERGKTPLILAVEKKHLGLVQRLLEQE-HIEINDTDSDGKTALLLAVELKLK 286 +VN+ + G TP +A +L +V+ L ++ ++N + G T L LAV K Sbjct: 61 NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWF 120 Query: 287 KIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLL 321 ++++ L + GAS D + S+ + L Sbjct: 121 EVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKL 155 >4D28-A nrPDB Length = 446 Score = 194 bits (493), Expect = 1e-49, Method: Composition-based stats. Identities = 57/270 (21%), Positives = 101/270 (37%), Gaps = 50/270 (18%) Query: 368 KYKIADTSEGGIYLGFYEKQE------VAVKTFCEG-------SPRAQREVSCLQSSREN 414 KY++ T G + + VA+K + + +RE+S ++ R + Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-H 68 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 ++V Y + + +++ + VH+G E+E +R + AV Sbjct: 69 PNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDE----SRKYFQQLVDAVAH 124 Query: 475 LHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI----------KWAGDPQEV------- 517 H S G H+DL+P+N+L+D+ ++DF S G P V Sbjct: 125 CH-SKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSG 183 Query: 518 ------KRDLEDLGRLVLYVVKKGSISFED-----LKAQSNEEVVQLSP--DEETKDLIH 564 D+ G ++L+V+ G + F + L + N P E K LIH Sbjct: 184 QGYDGSAADIWSCG-VILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWFSAEVKFLIH 242 Query: 565 RLFHPGEHVRDCLSDLLGHPFFWTWESRYR 594 R+ P R + + P+F R Sbjct: 243 RILDPNPKTRIQIQGIKKDPWFRKNYVPIR 272 >3EU9-A nrPDB Length = 240 Score = 193 bits (490), Expect = 3e-49, Method: Composition-based stats. Identities = 67/213 (31%), Positives = 98/213 (46%), Gaps = 14/213 (6%) Query: 19 RRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELL 78 R+ E+ LL A N +DLV+ + GA V+ + TPLH A + +V L Sbjct: 36 RQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQL 95 Query: 79 LRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGK- 137 +++GADP L G + LAA G ++ ++KG DV+ D G T M AA Sbjct: 96 MKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHS 155 Query: 138 VKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNA 197 V + L +VNL K ++ TAL A G+ V+ +LL E GA+V+A Sbjct: 156 VDPTRLLLTFNVSVNLGDKYHKN---------TALHWAVLAGNTTVISLLL-EAGANVDA 205 Query: 198 CDNMGRNALIHALLSSDDSDVEAITHLLLDHGA 230 + G +AL L+ +V I HL A Sbjct: 206 QNIKGESALD---LAKQRKNVWMINHLQEARQA 235 Score = 159 bits (402), Expect = 4e-39, Method: Composition-based stats. Identities = 60/238 (25%), Positives = 109/238 (45%), Gaps = 15/238 (6%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPV-L 87 ++KA Q + ++L+E G +V ++E T LH A +R D+V+ + GA L Sbjct: 13 IVKATQYGIYERCRELVEAGYDVRQPDKEN-VTLLHWAAINNRIDLVKYYISKGAIVDQL 71 Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147 +TP A G + ++ + GAD + D G + AA +G + +L + Sbjct: 72 GGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAK 131 Query: 148 GANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALI 207 G +V++ + G T LM AA + H LL VN D +N + Sbjct: 132 GQDVDMMD----------QNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTAL 181 Query: 208 HALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIE 265 H + + + + LLL+ GA+V+ + +G++ L LA ++K++ ++ L E + Sbjct: 182 HWAVLAGN---TTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQAK 236 Score = 139 bits (351), Expect = 3e-33, Method: Composition-based stats. Identities = 54/230 (23%), Positives = 96/230 (41%), Gaps = 15/230 (6%) Query: 99 AAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTK 158 A G + + + G DV + D T AA+ ++ +K+ +GA V+ Sbjct: 16 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVD------ 69 Query: 159 EDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDV 218 + +T L A +GH+ ++ L+ + GAD + D G + + A Sbjct: 70 ---QLGGDLNSTPLHWATRQGHLSMVVQLM-KYGADPSLIDGEGCSCIHLAAQFGH---- 121 Query: 219 EAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGK-TAL 277 +I L+ G DV++ + G TPL+ A + H RLL ++ +N D K TAL Sbjct: 122 TSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTAL 181 Query: 278 LLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKE 327 AV + LL + GA+ D ++ + + V + + +E Sbjct: 182 HWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQE 231 Score = 65.1 bits (157), Expect = 1e-10, Method: Composition-based stats. Identities = 26/140 (18%), Positives = 44/140 (31%), Gaps = 11/140 (7%) Query: 213 SDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSD 272 + + L++ G DV + T L A + LV+ + + I Sbjct: 16 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 75 Query: 273 GKTALLLAVELKLKKIAELLCKRGASTDCGD------LVMTARRNYDHSLVKVLLSHGAK 326 T L A + L K GA D + + A+ + S+V L++ G Sbjct: 76 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGH-TSIVAYLIAKGQD 134 Query: 327 EDF----HPPAEDWKPQSSH 342 D W +H Sbjct: 135 VDMMDQNGMTPLMWAAYRTH 154 >5H76-A nrPDB Length = 201 Score = 191 bits (485), Expect = 9e-49, Method: Composition-based stats. Identities = 56/163 (34%), Positives = 84/163 (51%), Gaps = 12/163 (7%) Query: 26 NHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADP 85 L++A + D V+ L+ GA+VN + G TPLH A +IVE+LL+HGAD Sbjct: 7 GRKLLEAARAGQDDEVRILMANGADVNAADNTGT-TPLHLAAYSGHLEIVEVLLKHGADV 65 Query: 86 VLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLY 145 G TP LAA G ++++++ L GADVN D G T AA +G ++ ++ L Sbjct: 66 DASDVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEIVEVLL 125 Query: 146 KRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188 K GA VN + K G TA + + G+ ++ +IL Sbjct: 126 KHGA-VNAQDKF----------GKTAFDISIDNGNEDLAQILA 157 Score = 149 bits (376), Expect = 5e-36, Method: Composition-based stats. Identities = 60/207 (28%), Positives = 98/207 (47%), Gaps = 16/207 (7%) Query: 96 FILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR 155 + AA AG +++ ++ GADVN D G T AA G ++ ++ L K GA+V+ Sbjct: 10 LLEAARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASD 69 Query: 156 KTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDD 215 G T L AA GH+E++++LL GADVNA D+ G L A Sbjct: 70 VF----------GYTPLHLAAYWGHLEIVEVLLKN-GADVNAMDSDGMTPLHLAAKWG-- 116 Query: 216 SDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKT 275 I +LL HGA VN + + GKT ++++ + L Q L E + + + + + + Sbjct: 117 --YLEIVEVLLKHGA-VNAQDKFGKTAFDISIDNGNEDLAQILAFYEILHLPNLNEEQRN 173 Query: 276 ALLLAVELKLKKIAELLCKRGASTDCG 302 A + +++ + A LL + D Sbjct: 174 AFIQSLKDDPSQSANLLAEAKKLNDAQ 200 Score = 148 bits (373), Expect = 1e-35, Method: Composition-based stats. Identities = 55/145 (37%), Positives = 75/145 (51%), Gaps = 9/145 (6%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 L++AA G + ++IL+ GADVNA DN G L A S I +LL HGAD Sbjct: 10 LLEAARAGQDDEVRILMAN-GADVNAADNTGTTPLHLAAYSGHLE----IVEVLLKHGAD 64 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAEL 291 V+ G TPL LA HL +V+ LL + ++N DSDG T L LA + +I E+ Sbjct: 65 VDASDVFGYTPLHLAAYWGHLEIVEVLL-KNGADVNAMDSDGMTPLHLAAKWGYLEIVEV 123 Query: 292 LCKRGASTDCGDLVMTARRNYDHSL 316 L K GA + D + +D S+ Sbjct: 124 LLKHGA-VNAQDKFG--KTAFDISI 145 Score = 134 bits (338), Expect = 1e-31, Method: Composition-based stats. Identities = 46/146 (31%), Positives = 70/146 (47%), Gaps = 11/146 (7%) Query: 210 LLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDT 269 LL + + + +L+ +GADVN G TPL LA HL +V+ LL + +++ + Sbjct: 10 LLEAARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLL-KHGADVDAS 68 Query: 270 DSDGKTALLLAVELKLKKIAELLCKRGASTDCGD------LVMTARRNYDHSLVKVLLSH 323 D G T L LA +I E+L K GA + D L + A+ Y +V+VLL H Sbjct: 69 DVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGY-LEIVEVLLKH 127 Query: 324 G---AKEDFHPPAEDWKPQSSHWGAA 346 G A++ F A D + + A Sbjct: 128 GAVNAQDKFGKTAFDISIDNGNEDLA 153 Score = 134 bits (337), Expect = 1e-31, Method: Composition-based stats. Identities = 48/162 (29%), Positives = 77/162 (47%), Gaps = 6/162 (3%) Query: 21 AAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLR 80 A L A + +++V+ LL+ GA+V+ + G +TPLH A +IVE+LL+ Sbjct: 35 ADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVFG-YTPLHLAAYWGHLEIVEVLLK 93 Query: 81 HGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKA 140 +GAD +G TP LAA G ++++++ L GA VN D +G TAF + G Sbjct: 94 NGADVNAMDSDGMTPLHLAAKWGYLEIVEVLLKHGA-VNAQDKFGKTAFDISIDNGNEDL 152 Query: 141 LKFL----YKRGANVNLRRKTKEDQERLRKGGATALMDAAEK 178 + L N+N ++ Q +A + A K Sbjct: 153 AQILAFYEILHLPNLNEEQRNAFIQSLKDDPSQSANLLAEAK 194 >5MIO-C nrPDB Length = 573 Score = 191 bits (485), Expect = 1e-48, Method: Composition-based stats. Identities = 56/155 (36%), Positives = 86/155 (55%), Gaps = 2/155 (1%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 L++A + D V+ L+ GA+VN + G TPLH A +IVE+LL+HGAD Sbjct: 414 LLEAARAGQDDEVRVLMANGADVNATDASG-LTPLHLAATYGHLEIVEVLLKHGADVSAS 472 Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG 148 G+TP LAA+ G ++++++ L GADVN D +G T AAV G +K ++ L K G Sbjct: 473 DLMGSTPLHLAALIGHLEIVEVLLKHGADVNAVDTWGDTPLRLAAVMGHLKIVEALLKHG 532 Query: 149 ANVNLRRKTKEDQERLR-KGGATALMDAAEKGHVE 182 A+VN + K + G+ L + +K ++E Sbjct: 533 ADVNAQDKFGKTAYDTSIDNGSEDLAEILQKLNLE 567 Score = 165 bits (417), Expect = 7e-41, Method: Composition-based stats. Identities = 54/165 (32%), Positives = 83/165 (50%), Gaps = 15/165 (9%) Query: 63 LHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECD 122 L A + ++D V +L+ +GAD +G TP LAA G ++++++ L GADV+ D Sbjct: 414 LLEAARAGQDDEVRVLMANGADVNATDASGLTPLHLAATYGHLEIVEVLLKHGADVSASD 473 Query: 123 FYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVE 182 G T AA+ G ++ ++ L K GA+VN G T L AA GH++ Sbjct: 474 LMGSTPLHLAALIGHLEIVEVLLKHGADVNAVDT----------WGDTPLRLAAVMGHLK 523 Query: 183 VLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLD 227 +++ LL GADVNA D G+ A S D+ E + +L Sbjct: 524 IVEALLKH-GADVNAQDKFGKTAYDT----SIDNGSEDLAEILQK 563 Score = 157 bits (397), Expect = 2e-38, Method: Composition-based stats. Identities = 55/165 (33%), Positives = 81/165 (49%), Gaps = 15/165 (9%) Query: 96 FILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR 155 + AA AG +++ ++ GADVN D G T AA YG ++ ++ L K GA+V+ Sbjct: 414 LLEAARAGQDDEVRVLMANGADVNATDASGLTPLHLAATYGHLEIVEVLLKHGADVSASD 473 Query: 156 KTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDD 215 G+T L AA GH+E++++LL GADVNA D G L A + Sbjct: 474 ----------LMGSTPLHLAALIGHLEIVEVLLKH-GADVNAVDTWGDTPLRLAAVMGHL 522 Query: 216 SDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLE 260 I LL HGADVN + + GKT +++ L + L + Sbjct: 523 K----IVEALLKHGADVNAQDKFGKTAYDTSIDNGSEDLAEILQK 563 Score = 152 bits (385), Expect = 4e-37, Method: Composition-based stats. Identities = 60/166 (36%), Positives = 84/166 (50%), Gaps = 16/166 (9%) Query: 129 FMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188 +EAA G+ ++ L GA+VN + G T L AA GH+E++++LL Sbjct: 414 LLEAARAGQDDEVRVLMANGADVNATDAS----------GLTPLHLAATYGHLEIVEVLL 463 Query: 189 DEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVE 248 GADV+A D MG L A L I +LL HGADVN G TPL LA Sbjct: 464 KH-GADVSASDLMGSTPLHLAALIGHLE----IVEVLLKHGADVNAVDTWGDTPLRLAAV 518 Query: 249 KKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCK 294 HL +V+ LL + ++N D GKTA +++ + +AE+L K Sbjct: 519 MGHLKIVEALL-KHGADVNAQDKFGKTAYDTSIDNGSEDLAEILQK 563 Score = 145 bits (367), Expect = 4e-35, Method: Composition-based stats. Identities = 52/145 (35%), Positives = 71/145 (48%), Gaps = 8/145 (5%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 L++AA G + +++L+ GADVNA D G L A I +LL HGAD Sbjct: 414 LLEAARAGQDDEVRVLMAN-GADVNATDASGLTPLHLAATYGHLE----IVEVLLKHGAD 468 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAEL 291 V+ G TPL LA HL +V+ LL + ++N D+ G T L LA + KI E Sbjct: 469 VSASDLMGSTPLHLAALIGHLEIVEVLL-KHGADVNAVDTWGDTPLRLAAVMGHLKIVEA 527 Query: 292 LCKRGASTDCGDLVMTARRNYDHSL 316 L K GA + D + YD S+ Sbjct: 528 LLKHGADVNAQDKFG--KTAYDTSI 550 Score = 131 bits (330), Expect = 1e-30, Method: Composition-based stats. Identities = 43/150 (28%), Positives = 65/150 (43%), Gaps = 10/150 (6%) Query: 206 LIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIE 265 L LL + + + +L+ +GADVN G TPL LA HL +V+ LL + + Sbjct: 410 LGKKLLEAARAGQDDEVRVLMANGADVNATDASGLTPLHLAATYGHLEIVEVLL-KHGAD 468 Query: 266 INDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYD-----HSLVKVL 320 ++ +D G T L LA + +I E+L K GA + D +V+ L Sbjct: 469 VSASDLMGSTPLHLAALIGHLEIVEVLLKHGADVNAVDTWGDTPLRLAAVMGHLKIVEAL 528 Query: 321 LSHG----AKEDFHPPAEDWKPQSSHWGAA 346 L HG A++ F A D + A Sbjct: 529 LKHGADVNAQDKFGKTAYDTSIDNGSEDLA 558 Score = 85.5 bits (210), Expect = 7e-17, Method: Composition-based stats. Identities = 34/139 (24%), Positives = 56/139 (40%), Gaps = 11/139 (7%) Query: 243 LILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCG 302 L+ A V+ L+ ++N TD+ G T L LA +I E+L K GA Sbjct: 414 LLEAARAGQDDEVRVLMA-NGADVNATDASGLTPLHLAATYGHLEIVEVLLKHGADVSAS 472 Query: 303 DLVMTARRNYD-----HSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPM 357 DL+ + + +V+VLL HGA + + W A + L I + Sbjct: 473 DLMGSTPLHLAALIGHLEIVEVLLKHGADVN---AVDTWGDTPLRLAAVMGHLK-IVEAL 528 Query: 358 IGKLKFFIDEKYKIADTSE 376 + K ++ + K T+ Sbjct: 529 L-KHGADVNAQDKFGKTAY 546 >6AUN-A nrPDB Length = 752 Score = 191 bits (484), Expect = 1e-48, Method: Composition-based stats. Identities = 66/273 (24%), Positives = 124/273 (45%), Gaps = 26/273 (9%) Query: 24 EDNHLLIKAVQNEDVDLVQQLL---EGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLR 80 E L A + D +++ +L+ +V + G T H AVQ +++LL + Sbjct: 151 EGCTPLHLACRKGDSEILVELVQYCHAQMDV---TDNKGETAFHYAVQGDNSQVLQLLGK 207 Query: 81 HGADPVLR-KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVK 139 + + + + K G TP LA G +++++ L A N GF A Sbjct: 208 NASAGLNQVNKQGLTPLHLACQMGKQEMVRVLLLCNARCNVMGPSGF-PIHTA------- 259 Query: 140 ALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACD 199 +KF K A + + + + + + GA+ L A + E+ ++LL G DV++ Sbjct: 260 -MKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKR-GCDVDSTS 314 Query: 200 NMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLL 259 G AL H + + D +LL +GA+ GE G TPL LA+ K ++ +++ L+ Sbjct: 315 AAGNTAL-HVAVMRNRFD---CVMVLLTYGANAGTPGEHGNTPLHLAISKDNMEMIKALI 370 Query: 260 EQEHIEINDTDSDGKTALLLAVELKLKKIAELL 292 E++ + G+T +A ++ K++ +L+ Sbjct: 371 -VFGAEVDTPNDFGETPAFMASKIS-KQLQDLM 401 Score = 153 bits (386), Expect = 3e-37, Method: Composition-based stats. Identities = 60/319 (18%), Positives = 110/319 (34%), Gaps = 24/319 (7%) Query: 17 SGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVE 76 + HL ++ E + + + N E E G TPLH A + +I+ Sbjct: 114 IRSHPSWTVTHLAVELGIRECFHHSRII----SCANSTENEEGCTPLHLACRKGDSEILV 169 Query: 77 LLLRH-GADPVLRKKNGATPFILAAIAGSVKLLKLFLSKG-ADVNECDFYGFTAFMEAAV 134 L+++ A + G T F A + ++L+L A +N+ + G T A Sbjct: 170 ELVQYCHAQMDVTDNKGETAFHYAVQGDNSQVLQLLGKNASAGLNQVNKQGLTPLHLACQ 229 Query: 135 YGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGAD 194 GK + ++ L A N+ + + A + ++++ + Sbjct: 230 MGKQEMVRVLLLCNARCNVMGPSGF-----------PIHTAMKFSQKGCAEMIISMDSSQ 278 Query: 195 VNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGL 254 +++ D + +H ++ + +LL G DV+ G T L +AV + Sbjct: 279 IHSKDPRYGASPLHWAKNA------EMARMLLKRGCDVDSTSAAGNTALHVAVMRNRFDC 332 Query: 255 VQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDH 314 V LL G T L LA+ ++ + L GA D + Sbjct: 333 VMVLLT-YGANAGTPGEHGNTPLHLAISKDNMEMIKALIVFGAEVDTPNDFGETPAFMAS 391 Query: 315 SLVKVLLSHGAKEDFHPPA 333 + K L PA Sbjct: 392 KISKQLQDLMPISRARKPA 410 >3KA0-A nrPDB Length = 320 Score = 190 bits (482), Expect = 2e-48, Method: Composition-based stats. Identities = 60/274 (21%), Positives = 105/274 (38%), Gaps = 53/274 (19%) Query: 362 KFFIDEKYKIADTSEG----GIYLGFYEK--QEVAVKTFCEGSPRAQREVSCLQSSRENS 415 K I + YK+ G G L + K QE + P+A+REV + + Sbjct: 10 KNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCP 69 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENE--EDEFARNVLSSIFKAVQ 473 H+V + C+ + + L+ R +D ++ + A ++ SI +A+Q Sbjct: 70 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 129 Query: 474 ELHLSCGYTHQDLQPQNILIDSKKA---AHLADFDKSI---------KWAGDPQEV---- 517 LH S H+D++P+N+L SK+ L DF + + P V Sbjct: 130 YLH-SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEV 188 Query: 518 --------KRDLEDLGRLVLYVVKKGSISFED---------LKAQ--------SNEEVVQ 552 D+ LG +++Y++ G F +K + N E + Sbjct: 189 LGPEKYDKSCDMWSLG-VIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 247 Query: 553 LSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 +S EE K LI L R +++ + HP+ Sbjct: 248 VS--EEVKMLIRNLLKTEPTQRMTITEFMNHPWI 279 >2OZA-A nrPDB Length = 356 Score = 190 bits (482), Expect = 2e-48, Method: Composition-based stats. Identities = 60/274 (21%), Positives = 105/274 (38%), Gaps = 53/274 (19%) Query: 362 KFFIDEKYKIADTSEG----GIYLGFYEK--QEVAVKTFCEGSPRAQREVSCLQSSRENS 415 K I + YK+ G G L + K QE + P+A+REV + + Sbjct: 12 KNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCP 71 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENE--EDEFARNVLSSIFKAVQ 473 H+V + C+ + + L+ R +D ++ + A ++ SI +A+Q Sbjct: 72 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 131 Query: 474 ELHLSCGYTHQDLQPQNILIDSKKA---AHLADFDKSIK---------WAGDPQEV---- 517 LH S H+D++P+N+L SK+ L DF + + P V Sbjct: 132 YLH-SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 190 Query: 518 --------KRDLEDLGRLVLYVVKKGSISFED---------LKAQ--------SNEEVVQ 552 D+ LG +++Y++ G F +K + N E + Sbjct: 191 LGPEKYDKSCDMWSLG-VIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 249 Query: 553 LSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 +S EE K LI L R +++ + HP+ Sbjct: 250 VS--EEVKMLIRNLLKTEPTQRMTITEFMNHPWI 281 >1NY3-A nrPDB Length = 400 Score = 190 bits (482), Expect = 2e-48, Method: Composition-based stats. Identities = 60/274 (21%), Positives = 105/274 (38%), Gaps = 53/274 (19%) Query: 362 KFFIDEKYKIADTSEG----GIYLGFYEK--QEVAVKTFCEGSPRAQREVSCLQSSRENS 415 K I + YK+ G G L + K QE + P+A+REV + + Sbjct: 56 KNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCP 115 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENE--EDEFARNVLSSIFKAVQ 473 H+V + C+ + + L+ R +D ++ + A ++ SI +A+Q Sbjct: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 Query: 474 ELHLSCGYTHQDLQPQNILIDSKKA---AHLADFDKSIK---------WAGDPQEV---- 517 LH S H+D++P+N+L SK+ L DF + + P V Sbjct: 176 YLH-SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 234 Query: 518 --------KRDLEDLGRLVLYVVKKGSISFED---------LKAQ--------SNEEVVQ 552 D+ LG +++Y++ G F +K + N E + Sbjct: 235 LGPEKYDKSCDMWSLG-VIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 293 Query: 553 LSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 +S EE K LI L R +++ + HP+ Sbjct: 294 VS--EEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 >4CQG-A nrPDB Length = 331 Score = 186 bits (472), Expect = 3e-47, Method: Composition-based stats. Identities = 58/265 (21%), Positives = 100/265 (37%), Gaps = 49/265 (18%) Query: 369 YKIADTSEGGIYLGF------YEKQEVAVKTFCE-----GSPRAQREVSCLQSSRENSHL 417 Y++ +T G + + VA+K + PR + E+ L+S R + H+ Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLR-HQHI 69 Query: 418 VTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL 477 Y + +F+ + C D +D +EE+ R V I AV +H Sbjct: 70 CQLYHVLETKNKIFMVLEYCPGG--ELFDYIISQDRLSEEE--TRVVFRQILSAVAYVH- 124 Query: 478 SCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE--------------------- 516 S GY H+DL+P+N+L D L DF K G+ Sbjct: 125 SQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKS 184 Query: 517 ---VKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETK-------DLIHRL 566 + D+ +G ++LYV+ G + F+D + + + E K L+ ++ Sbjct: 185 YLGSEADVWSMG-ILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQM 243 Query: 567 FHPGEHVRDCLSDLLGHPFFWTWES 591 R + +LL HP+ S Sbjct: 244 LQVDPKKRISMRNLLNHPWVMQDYS 268 >4D2V-A nrPDB Length = 356 Score = 185 bits (470), Expect = 5e-47, Method: Composition-based stats. Identities = 58/262 (22%), Positives = 99/262 (37%), Gaps = 53/262 (20%) Query: 369 YKIADTSEGGIYLG------FYEKQEVAVKTFCE-----GSPRAQREVSCLQSSRENSHL 417 Y++ +T G + + VA+K + PR + E+ L++ R + H+ Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLR-HQHI 89 Query: 418 VTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL 477 Y +F+ + C D +D +EE+ R V I AV +H Sbjct: 90 CQLYHVLETANKIFMVLEYCPGG--ELFDYIISQDRLSEEE--TRVVFRQIVSAVAYVH- 144 Query: 478 SCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE--------------------- 516 S GY H+DL+P+N+L D L DF K G+ Sbjct: 145 SQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKS 204 Query: 517 ---VKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQ---------LSPDEETKDLIH 564 + D+ +G ++LYV+ G + F+D A + + LSP L+ Sbjct: 205 YLGSEADVWSMG-ILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSIL--LLQ 261 Query: 565 RLFHPGEHVRDCLSDLLGHPFF 586 ++ R + +LL HP+ Sbjct: 262 QMLQVDPKKRISMKNLLNHPWI 283 >4J52-A nrPDB Length = 293 Score = 185 bits (469), Expect = 7e-47, Method: Composition-based stats. Identities = 51/258 (19%), Positives = 99/258 (38%), Gaps = 44/258 (17%) Query: 369 YKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSC---LQSSRENSHLVTFYGSES 425 ++I+D ++ G + + +K P + ++S + S + H+V F+G Sbjct: 31 FEISDADTKEVFAGKIVPKSLLLK------PHQREKMSMEISIHRSLAHQHVVGFHGFFE 84 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 +FV + LC + + L++H+ E + AR L I Q LH + H+D Sbjct: 85 DNDFVFVVLELCRR--RSLLELHKRRKALTEPE--ARYYLRQIVLGCQYLHRN-RVIHRD 139 Query: 486 LQPQNILIDSKKAAHLADFDKSIK----------WAGDPQEV------------KRDLED 523 L+ N+ ++ + DF + K G P + + D+ Sbjct: 140 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWS 199 Query: 524 LGRLVLYVVKKGSISFED-------LKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDC 576 +G ++ Y + G FE L+ + NE + + LI ++ R Sbjct: 200 IGCIM-YTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPT 258 Query: 577 LSDLLGHPFFWTWESRYR 594 +++LL FF + R Sbjct: 259 INELLNDEFFTSGYIPAR 276 >2OU7-A nrPDB Length = 335 Score = 184 bits (467), Expect = 1e-46, Method: Composition-based stats. Identities = 51/258 (19%), Positives = 99/258 (38%), Gaps = 44/258 (17%) Query: 369 YKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSC---LQSSRENSHLVTFYGSES 425 ++I+D ++ G + + +K P + ++S + S + H+V F+G Sbjct: 58 FEISDADTKEVFAGKIVPKSLLLK------PHQREKMSMEISIHRSLAHQHVVGFHGFFE 111 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 +FV + LC + + L++H+ E + AR L I Q LH + H+D Sbjct: 112 DNDFVFVVLELCRR--RSLLELHKRRKALTEPE--ARYYLRQIVLGCQYLHRN-RVIHRD 166 Query: 486 LQPQNILIDSKKAAHLADFDKSIK----------WAGDPQEV------------KRDLED 523 L+ N+ ++ + DF + K G P + + D+ Sbjct: 167 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWS 226 Query: 524 LGRLVLYVVKKGSISFED-------LKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDC 576 +G ++ Y + G FE L+ + NE + + LI ++ R Sbjct: 227 IGCIM-YTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPT 285 Query: 577 LSDLLGHPFFWTWESRYR 594 +++LL FF + R Sbjct: 286 INELLNDEFFTSGYIPAR 303 >4CZT-A nrPDB Length = 464 Score = 179 bits (453), Expect = 5e-45, Method: Composition-based stats. Identities = 52/273 (19%), Positives = 99/273 (36%), Gaps = 52/273 (19%) Query: 368 KYKIADTSEGGIYL------GFYEKQEVAVKTFCEG-------SPRAQREVSCLQSSREN 414 KY++ T G + VA+K + + +RE+S ++ ++ Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK-LIKH 70 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 +++ + + + ++ + D E++ AR + AV Sbjct: 71 PNVIRMFEVMASKTKIYFVLEFVTGG--ELFDKISSNGRLKEDE--ARKYFQQLINAVDY 126 Query: 475 LHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI------------KWAGDPQEV----- 517 H S G H+DL+P+N+L+D+ A ++DF S G P V Sbjct: 127 CH-SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 185 Query: 518 --------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVV-----QLSP--DEETKDL 562 K DL G ++L+V+ G + FED S + + P K L Sbjct: 186 NNKGYDGAKADLWSCG-VILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL 244 Query: 563 IHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRT 595 I R+ P R ++++ + +F + Sbjct: 245 IKRILDPNPATRITFAEVIENEWFKKGYKAPKF 277 >4MVF-A nrPDB Length = 506 Score = 176 bits (445), Expect = 4e-44, Method: Composition-based stats. Identities = 59/316 (18%), Positives = 112/316 (35%), Gaps = 52/316 (16%) Query: 324 GAKEDFHPPAEDWKPQS-----SHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGG 378 G+ + + D+K S G + + GKL+ K+ + G Sbjct: 13 GSDPNTSKQSNDYKYDINTSCISREGTTTLERKNLILCHSGKLEDKYIIDEKLGQGTYGC 72 Query: 379 IYLGF--YEKQEVAVKTFCEG----SPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFV 432 +Y G Q A+K + R +E+ ++ ++ ++V Y + + ++++ Sbjct: 73 VYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKL-DHPNIVKLYETYENDNYIYL 131 Query: 433 CVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNIL 492 + LC D + ++ A ++ IF A+ LH S H+DL+P+N L Sbjct: 132 IMELCSG--RELFDSIIEN--GSFTEKNAATIMKQIFSAIFYLH-SLNIVHRDLKPENFL 186 Query: 493 IDSKKA---AHLADFDKSIKW---------AGDPQEV-----------KRDLEDLGRLVL 529 S+ + DF S AG P V K D+ G +++ Sbjct: 187 FQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDGKYDKKCDIWSSG-VIM 245 Query: 530 YVVKKGSISFEDLKAQSNEEVVQ-----------LSPDEETKDLIHRLFHPGEHVRDCLS 578 Y + G F + V+ S + K+LI +L + R + Sbjct: 246 YTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNLITKLLTYNPNERCTIE 305 Query: 579 DLLGHPFFWTWESRYR 594 + L HP+ + Sbjct: 306 EALNHPWITQMTKSHE 321 >4Z68-A nrPDB Length = 155 Score = 175 bits (443), Expect = 7e-44, Method: Composition-based stats. Identities = 52/152 (34%), Positives = 77/152 (50%), Gaps = 2/152 (1%) Query: 24 EDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGG-WTPLHNAVQMSREDIVELLLRHG 82 E + L++A + DV+ V++L +VN ++ EG TPLH A +R +VE LL+HG Sbjct: 2 EADRQLLEAAKAGDVETVKKLCTVQ-SVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHG 60 Query: 83 ADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALK 142 AD + K G P A G ++ +L + GA VN D + FT EAA GK + K Sbjct: 61 ADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICK 120 Query: 143 FLYKRGANVNLRRKTKEDQERLRKGGATALMD 174 L + GA+ + + L K G T + D Sbjct: 121 LLLQHGADPTKKNRDGNTPLDLVKDGDTDIQD 152 Score = 119 bits (299), Expect = 4e-27, Method: Composition-based stats. Identities = 50/165 (30%), Positives = 72/165 (43%), Gaps = 19/165 (11%) Query: 96 FILAAIAGSVKLLKLFLSKGADVNECDFYGF--TAFMEAAVYGKVKALKFLYKRGANVNL 153 + AA AG V+ +K VN D G T AA Y +V +++L + GA+V+ Sbjct: 7 LLEAAKAGDVETVKKL-CTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA 65 Query: 154 RRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSS 213 + K GG L +A GH EV ++L+ GA VN D + + +H + Sbjct: 66 KDK----------GGLVPLHNACSYGHYEVAELLVKH-GAVVNVAD-LWKFTPLHEAAAK 113 Query: 214 DDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRL 258 I LLL HGAD + G TPL L V+ + L Sbjct: 114 GK---YEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQDLL 154 Score = 110 bits (276), Expect = 1e-24, Method: Composition-based stats. Identities = 38/126 (30%), Positives = 56/126 (44%), Gaps = 2/126 (1%) Query: 19 RRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELL 78 R + L A V +V+ LL+ GA+V+ +++GG PLHNA ++ ELL Sbjct: 31 RDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA-KDKGGLVPLHNACSYGHYEVAELL 89 Query: 79 LRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKV 138 ++HGA + TP AA G ++ KL L GAD + + G T G Sbjct: 90 VKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDT 148 Query: 139 KALKFL 144 L Sbjct: 149 DIQDLL 154 Score = 106 bits (264), Expect = 4e-23, Method: Composition-based stats. Identities = 37/144 (25%), Positives = 59/144 (40%), Gaps = 5/144 (3%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 L++AA+ G VE +K L VN D GR + L + + ++ LL HGAD Sbjct: 7 LLEAAKAGDVETVKKLCTVQ--SVNCRDIEGRQST--PLHFAAGYNRVSVVEYLLQHGAD 62 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAEL 291 V+ + + G PL A H + + L+ + +N D T L A +I +L Sbjct: 63 VHAKDKGGLVPLHNACSYGHYEVAELLV-KHGAVVNVADLWKFTPLHEAAAKGKYEICKL 121 Query: 292 LCKRGASTDCGDLVMTARRNYDHS 315 L + GA + + Sbjct: 122 LLQHGADPTKKNRDGNTPLDLVKD 145 Score = 55.5 bits (132), Expect = 9e-08, Method: Composition-based stats. Identities = 27/118 (22%), Positives = 45/118 (38%), Gaps = 12/118 (10%) Query: 237 ERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGK--TALLLAVELKLKKIAELLCK 294 L+ A + + V++L + +N D +G+ T L A + E L + Sbjct: 1 SEADRQLLEAAKAGDVETVKKLCTVQ--SVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQ 58 Query: 295 RGASTDCGDLVMTARRN----YDH-SLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAAL 347 GA D + Y H + ++L+ HGA + A+ WK H AA Sbjct: 59 HGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV---ADLWKFTPLHEAAAK 113 >3COM-A nrPDB Length = 314 Score = 172 bits (436), Expect = 4e-43, Method: Composition-based stats. Identities = 62/281 (22%), Positives = 119/281 (42%), Gaps = 44/281 (15%) Query: 370 KIADTSEGGIYLGFYEK--QEVAVKTFCEGSPRAQ--REVSCLQSSRENSHLVTFYGSES 425 K+ + S G +Y +++ Q VA+K S + +E+S +Q ++ H+V +YGS Sbjct: 36 KLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQC-DSPHVVKYYGSYF 94 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 L++ + C + D+ R + EDE A +L S K ++ LH H+D Sbjct: 95 KNTDLWIVMEYCGAG--SVSDIIRLRNKTLTEDEIA-TILQSTLKGLEYLHF-MRKIHRD 150 Query: 486 LQPQNILIDSKKAAHLADFDKSIKWAGD---------------PQEVK-------RDLED 523 ++ NIL++++ A LADF + + P+ ++ D+ Sbjct: 151 IKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWS 210 Query: 524 LGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETK----------DLIHRLFHPGEHV 573 LG + + +G + D+ ++ +P + D + + Sbjct: 211 LGITAI-EMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQ 269 Query: 574 RDCLSDLLGHPFFWTWESRYRTLRNVGNES-DIKTRKSESE 613 R + LL HPF + LR++ NE+ D+K ++ ES+ Sbjct: 270 RATATQLLQHPFVRS-AKGVSILRDLINEAMDVKLKRQESQ 309 >3ZKJ-A nrPDB Length = 261 Score = 169 bits (427), Expect = 5e-42, Method: Composition-based stats. Identities = 50/221 (22%), Positives = 88/221 (39%), Gaps = 18/221 (8%) Query: 59 GWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADV 118 W+P+H A + + L+ G + + +P A + G + +K+ L GA V Sbjct: 3 DWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQV 62 Query: 119 NECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEK 178 N T A V G + L + GA+V A+ + +AA + Sbjct: 63 NGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDL-----------ASPIHEAARR 111 Query: 179 GHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGER 238 GHVE + L+ G +++ + L A ++ A LL+ GADVN +G+ Sbjct: 112 GHVECVNSLI-AYGGNIDHKISHLGTPLYLAC----ENQQRACVKKLLESGADVN-QGKG 165 Query: 239 GKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLL 279 +PL L L++ + +++GK + L Sbjct: 166 QDSPLHAVARTASEELACLLMD-FGADTQAKNAEGKRPVEL 205 Score = 122 bits (307), Expect = 4e-28, Method: Composition-based stats. Identities = 50/218 (22%), Positives = 83/218 (38%), Gaps = 18/218 (8%) Query: 93 ATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVN 152 +P AAI G L+ +S+G VN + EA + G + +K L K GA VN Sbjct: 4 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 63 Query: 153 LRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLS 212 + T L +A G + + +LL GA V + L + Sbjct: 64 ----------GVTADWHTPLFNACVSGSWDCVNLLLQH-GASV-----QPESDLASPIHE 107 Query: 213 SDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSD 272 + + L+ +G +++ + TPL LA E + V++LLE ++N Sbjct: 108 AARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLE-SGADVN-QGKG 165 Query: 273 GKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARR 310 + L +++A LL GA T + Sbjct: 166 QDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPV 203 Score = 115 bits (288), Expect = 6e-26, Method: Composition-based stats. Identities = 59/266 (22%), Positives = 95/266 (35%), Gaps = 63/266 (23%) Query: 22 AVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRH 81 + L +A + V+ LL+ GA VN + TPL NA D V LLL+H Sbjct: 33 TADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADW-HTPLFNACVSGSWDCVNLLLQH 91 Query: 82 GADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKAL 141 GA + + A+P AA G V+ + ++ G +++ + T A + + Sbjct: 92 GASVQ-PESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACV 150 Query: 142 KFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNM 201 K L + GA+VN KG + L A E+ +L+D GAD Sbjct: 151 KKLLESGADVN-----------QGKGQDSPLHAVARTASEELACLLMD-FGAD------- 191 Query: 202 GRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQ 261 + GK P+ L + L Q LE+ Sbjct: 192 ------------------------------TQAKNAEGKRPVELVPPES--PLAQLFLER 219 Query: 262 EHIEINDTDSDGKTALLLAVELKLKK 287 +G +L+ L+++K Sbjct: 220 ----------EGPPSLMQLCRLRIRK 235 Score = 103 bits (257), Expect = 3e-22, Method: Composition-based stats. Identities = 53/206 (25%), Positives = 82/206 (39%), Gaps = 23/206 (11%) Query: 126 FTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLK 185 ++ EAA++G +L+ L +G VN+ + + L +A GH+ +K Sbjct: 4 WSPMHEAAIHGHQLSLRNLISQGWAVNI----------ITADHVSPLHEACLGGHLSCVK 53 Query: 186 ILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLIL 245 ILL GA VN L +A +S +LLL HGA V +P+ Sbjct: 54 ILLKH-GAQVNGVTADWHTPLFNACVSG----SWDCVNLLLQHGASVQ-PESDLASPIHE 107 Query: 246 AVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGD-- 303 A + H+ V L+ + G T L LA E + + + L + GA + G Sbjct: 108 AARRGHVECVNSLIAYGGNIDHKISHLG-TPLYLACENQQRACVKKLLESGADVNQGKGQ 166 Query: 304 ---LVMTARRNYDHSLVKVLLSHGAK 326 L AR L +L+ GA Sbjct: 167 DSPLHAVARTA-SEELACLLMDFGAD 191 Score = 52.8 bits (125), Expect = 6e-07, Method: Composition-based stats. Identities = 35/165 (21%), Positives = 57/165 (34%), Gaps = 23/165 (13%) Query: 241 TPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTD 300 +P+ A H ++ L+ Q +N +D + L A ++L K GA + Sbjct: 5 SPMHEAAIHGHQLSLRNLISQGWA-VNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 63 Query: 301 CGDLVMTARRNYDH---------SLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLH 351 +TA + V +LL HGA P D S AA + Sbjct: 64 G----VTADWHTPLFNACVSGSWDCVNLLLQHGASVQ---PESDLA--SPIHEAARRGHV 114 Query: 352 RIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCE 396 +I + + +KI+ +YL +Q VK E Sbjct: 115 ECVNSLI---AYGGNIDHKISH-LGTPLYLACENQQRACVKKLLE 155 >6AO5-A nrPDB Length = 362 Score = 166 bits (419), Expect = 4e-41, Method: Composition-based stats. Identities = 55/277 (19%), Positives = 113/277 (40%), Gaps = 44/277 (15%) Query: 370 KIADTSEGGIYLGFYEK--QEVAVKTFCEGSPRAQ--REVSCLQSSRENSHLVTFYGSES 425 K+ + S G ++ +++ Q VA+K S + +E+S +Q ++ ++V +YGS Sbjct: 17 KLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQC-DSPYVVKYYGSYF 75 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 L++ + C + D+ R + EDE A +L S K ++ LH H++ Sbjct: 76 KNTDLWIVMEYCGAG--SVSDIIRLRNKTLIEDEIA-TILKSTLKGLEYLHF-MRKIHRN 131 Query: 486 LQPQNILIDSKKAAHLADFDKSIKWAGD---------------PQEVK-------RDLED 523 ++ NIL++++ A LADF + + P+ ++ D+ Sbjct: 132 IKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWS 191 Query: 524 LGRLVLYVVKKGSISFEDLKAQSNEEVVQLSP----------DEETKDLIHRLFHPGEHV 573 LG + + +G + D+ ++ +P ++ D + + Sbjct: 192 LGITSI-EMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQ 250 Query: 574 RDCLSDLLGHPFFWTWESRYRTLRN-VGNESDIKTRK 609 R + LL HPF LR+ + +IK ++ Sbjct: 251 RATATQLLQHPFI-KNAKPVSILRDLITEAMEIKAKR 286 >4LG4-A nrPDB Length = 299 Score = 166 bits (419), Expect = 4e-41, Method: Composition-based stats. Identities = 55/277 (19%), Positives = 113/277 (40%), Gaps = 44/277 (15%) Query: 370 KIADTSEGGIYLGFYEK--QEVAVKTFCEGSPRAQ--REVSCLQSSRENSHLVTFYGSES 425 K+ + S G ++ +++ Q VA+K S + +E+S +Q ++ ++V +YGS Sbjct: 18 KLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQC-DSPYVVKYYGSYF 76 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 L++ + C + D+ R + EDE A +L S K ++ LH H++ Sbjct: 77 KNTDLWIVMEYCGAG--SVSDIIRLRNKTLIEDEIA-TILKSTLKGLEYLHF-MRKIHRN 132 Query: 486 LQPQNILIDSKKAAHLADFDKSIKWAGD---------------PQEVK-------RDLED 523 ++ NIL++++ A LADF + + P+ ++ D+ Sbjct: 133 IKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWS 192 Query: 524 LGRLVLYVVKKGSISFEDLKAQSNEEVVQLSP----------DEETKDLIHRLFHPGEHV 573 LG + + +G + D+ ++ +P ++ D + + Sbjct: 193 LGITSI-EMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQ 251 Query: 574 RDCLSDLLGHPFFWTWESRYRTLRN-VGNESDIKTRK 609 R + LL HPF LR+ + +IK ++ Sbjct: 252 RATATQLLQHPFI-KNAKPVSILRDLITEAMEIKAKR 287 >2VN9-A nrPDB Length = 301 Score = 165 bits (417), Expect = 7e-41, Method: Composition-based stats. Identities = 59/271 (21%), Positives = 104/271 (38%), Gaps = 57/271 (21%) Query: 365 IDEKYKIADTSEGGIYLGFYE------KQEVAVKTFCEGSPRAQREVSCLQSSR-----E 413 + ++Y++ + G + QE A K A+ + +R + Sbjct: 2 MTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLK 61 Query: 414 NSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQ 473 + ++V + S S G ++ L + + +E D A + + I ++V Sbjct: 62 HPNIVRLHDSISEEGFHYLVFDLVTGG--ELFEDIVAREYYSEAD--ASHCIQQILESVN 117 Query: 474 ELHLSCGYTHQDLQPQNILIDSKK---AAHLADFDKSIKWAGD----------------- 513 HL+ G H+DL+P+N+L+ SK A LADF +I+ GD Sbjct: 118 HCHLN-GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPE 176 Query: 514 -----PQEVKRDLEDLGRLVLYVVKKGSISFED-----LKAQ--------SNEEVVQLSP 555 P D+ G ++LY++ G F D L Q + E ++P Sbjct: 177 VLRKDPYGKPVDMWACG-VILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTP 235 Query: 556 DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 E KDLI+++ R S+ L HP+ Sbjct: 236 --EAKDLINKMLTINPAKRITASEALKHPWI 264 >2Y7J-A nrPDB Length = 365 Score = 162 bits (411), Expect = 4e-40, Method: Composition-based stats. Identities = 70/308 (22%), Positives = 103/308 (33%), Gaps = 77/308 (25%) Query: 333 AEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEK--QEVA 390 ED P W AA Y+ D K I + + E A Sbjct: 79 PEDELPD---WAAA----KEFYQK--------YDPKDVIGRGVSSVVRRCVHRATGHEFA 123 Query: 391 VKTFCEGSPR------------AQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCE 438 VK + R +RE L+ + H++T S +F+ L Sbjct: 124 VKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMR 183 Query: 439 QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA 498 + L + E V E E R+++ S+ +AV LH + H+DL+P+NIL+D Sbjct: 184 ---KGELFDYLTEKVALSEKE-TRSIMRSLLEAVSFLHAN-NIVHRDLKPENILLDDNMQ 238 Query: 499 AHLADFDKS---------IKWAGDPQEV------------------KRDLEDLGRLVLYV 531 L+DF S + G P + + DL G ++L+ Sbjct: 239 IRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACG-VILFT 297 Query: 532 VKKGSISFEDLKAQ-------------SNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLS 578 + GS F + S+ E S KDLI RL R Sbjct: 298 LLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRS--STVKDLISRLLQVDPEARLTAE 355 Query: 579 DLLGHPFF 586 L HPFF Sbjct: 356 QALQHPFF 363 >4OT9-A nrPDB Length = 359 Score = 162 bits (410), Expect = 5e-40, Method: Composition-based stats. Identities = 75/291 (25%), Positives = 108/291 (37%), Gaps = 35/291 (12%) Query: 22 AVEDNHLLIKAVQNEDVDLVQQL-----LEGGANVNFQEEEGGWTPLHNAVQMSREDIVE 76 + L A+ + +++Q+ V TPLH AV + +V Sbjct: 79 DENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVS 138 Query: 77 LLLRHGADPVLRKKNGATPFILA--AIAGSVKLLKLFLSKGAD-----VNECDFYGFTAF 129 LLR GADP L ++G + LA A AG+ +LL+ L GA ++ DF G Sbjct: 139 FLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEGLYPV 198 Query: 130 MEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLD 189 A + L L GA V R+GG TAL A E + ++ L+ Sbjct: 199 HLAVRARSPECLDLLVDSGAEVEATE---------RQGGRTALHLATEMEELGLVTHLVT 249 Query: 190 EMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEK 249 ++ A+VNA G L A +T LLL GAD++ E PL Sbjct: 250 KLRANVNARTFAGNTPLHLAA----GLGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTS 305 Query: 250 KHLGLVQRLLEQEHIEINDTDSD-GKTALLLAVELKLKKIAELLCKRGAST 299 + E + S G T L L K+ LL +T Sbjct: 306 DSDSDSE------GPEKDTRSSFRGHTPLDLTCS---TKVKTLLLNAAQNT 347 Score = 132 bits (331), Expect = 7e-31, Method: Composition-based stats. Identities = 60/226 (26%), Positives = 93/226 (41%), Gaps = 19/226 (8%) Query: 87 LRKKNGATPFILAAIAGSVKLLK---LFLSKGAD---VNECDFYGFTAFMEAAVYGKVKA 140 + +NG TP LA I G +++ + D VN + T A + G+ Sbjct: 77 AQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSV 136 Query: 141 LKFLYKRGANVNLRRKTKEDQERLRKGGATALMDA--AEKGHVEVLKILLDEMGADVNAC 198 + FL + GA+ L L + G +A+ A A G E+L+ LL V Sbjct: 137 VSFLLRVGADPAL----------LDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQL 186 Query: 199 DNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNV-RGERGKTPLILAVEKKHLGLVQR 257 +M ++ + + + LL+D GA+V + G+T L LA E + LGLV Sbjct: 187 LHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTH 246 Query: 258 LLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGD 303 L+ + +N G T L LA L + LL K GA + Sbjct: 247 LVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAEN 292 Score = 85.1 bits (209), Expect = 1e-16, Method: Composition-based stats. Identities = 32/116 (27%), Positives = 49/116 (42%), Gaps = 1/116 (0%) Query: 15 SSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDI 74 E + + AV+ + + L++ GA V E +GG T LH A +M + Sbjct: 184 PQLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGL 243 Query: 75 VELLL-RHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAF 129 V L+ + A+ R G TP LAA G L +L L GAD++ + Sbjct: 244 VTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPL 299 Score = 62.4 bits (150), Expect = 7e-10, Method: Composition-based stats. Identities = 26/114 (22%), Positives = 45/114 (39%), Gaps = 12/114 (10%) Query: 224 LLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLL-----EQEHIEINDTDSDGKTALL 278 LL + + E G TPL LA+ ++++++ Q+ +N T+ +T L Sbjct: 67 LLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLH 126 Query: 279 LAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDH-------SLVKVLLSHGA 325 LAV + L + GA D + + L++ LL GA Sbjct: 127 LAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGA 180 Score = 34.3 bits (77), Expect = 0.19, Method: Composition-based stats. Identities = 15/90 (16%), Positives = 28/90 (31%), Gaps = 11/90 (12%) Query: 248 EKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAE---LLCKRGAS---TDC 301 + + LL + + D +G T L LA+ + E + + Sbjct: 57 DYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNL 116 Query: 302 GDLVMTARRNYD-----HSLVKVLLSHGAK 326 + + + S+V LL GA Sbjct: 117 TNHLHQTPLHLAVITGQTSVVSFLLRVGAD 146 >5FG8-A nrPDB Length = 285 Score = 162 bits (409), Expect = 7e-40, Method: Composition-based stats. Identities = 51/276 (18%), Positives = 98/276 (35%), Gaps = 59/276 (21%) Query: 366 DEKYKIADTSEGGIYLGF-----------YEKQEVAVKTFC-EGSPRAQREVSCLQSSRE 413 + Y I + G + + + + K + +RE + Sbjct: 13 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLH- 71 Query: 414 NSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQ 473 + ++V + S + ++ L + + +E D A + + I ++V Sbjct: 72 HPNIVRLHDSIQEENYHYLVFDLVTGG--ELFEDIVAREFYSEAD--ASHCIQQILESVN 127 Query: 474 ELHLSCGYTHQDLQPQNILIDSKK---AAHLADFDKSIKWAGD----------------- 513 H + G H+DL+P+N+L+ SK A LADF +I+ GD Sbjct: 128 HCHQN-GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPE 186 Query: 514 -----PQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQ-------------SNEEVVQLSP 555 P D+ G ++LY++ G F D + E ++P Sbjct: 187 VLKKEPYGKSVDIWACG-VILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTP 245 Query: 556 DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWES 591 E K+LI+++ + R ++ L HP+ E Sbjct: 246 --EAKNLINQMLTVNPNKRITAAEALKHPWICQRER 279 >3H4J-B nrPDB Length = 336 Score = 161 bits (407), Expect = 1e-39, Method: Composition-based stats. Identities = 55/257 (21%), Positives = 96/257 (37%), Gaps = 46/257 (17%) Query: 368 KYKIADTSEGGIYLGFY--EKQEVAVKTFCEGS-------PRAQREVSCLQSSRENSHLV 418 + + + S G + L + +Q+VA+K R +RE+S L+ R + H++ Sbjct: 14 RETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLR-HPHII 72 Query: 419 TFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLS 478 Y + + + + L + E EDE R I A++ H Sbjct: 73 KLYDVITTPTDIVMVIEYAG----GELFDYIVEKKRMTEDE-GRRFFQQIICAIEYCHR- 126 Query: 479 CGYTHQDLQPQNILIDSKKAAHLADFDKS---------IKWAGDPQEV------------ 517 H+DL+P+N+L+D +ADF S G P Sbjct: 127 HKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAG 186 Query: 518 -KRDLEDLGRLVLYVVKKGSISFED-----LKAQSNEEVVQLSP--DEETKDLIHRLFHP 569 + D+ G +VLYV+ G + F+D L + N V + + LI R+ Sbjct: 187 PEVDVWSCG-IVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFLSPGAQSLIRRMIVA 245 Query: 570 GEHVRDCLSDLLGHPFF 586 R + ++ P+F Sbjct: 246 DPMQRITIQEIRRDPWF 262 >3F3Z-A nrPDB Length = 277 Score = 159 bits (402), Expect = 4e-39, Method: Composition-based stats. Identities = 47/268 (17%), Positives = 90/268 (33%), Gaps = 47/268 (17%) Query: 359 GKLKFFIDEKYKIADTSEGGIYLGFYEKQEV--AVKTFC----EGSPRAQREVSCLQSSR 412 G + + + I S G + + + + A K E R ++E+ ++ S Sbjct: 5 GDINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMK-SL 63 Query: 413 ENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAV 472 ++ +++ Y + +++ + LC VH+ + A ++ + AV Sbjct: 64 DHPNIIRLYETFEDNTDIYLVMELCTGGELFERVVHKR----VFRESDAARIMKDVLSAV 119 Query: 473 QELHLSCGYTHQDLQPQNILI---DSKKAAHLADFDKSIKWA---------GDPQEV--- 517 H H+DL+P+N L L DF + ++ G P V Sbjct: 120 AYCH-KLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQ 178 Query: 518 --------KRDLEDLGRLVLYVVKKGSISFEDLKAQ-----------SNEEVVQLSPDEE 558 + D G +++YV+ G F + E L+ + Sbjct: 179 VLEGLYGPECDEWSAG-VMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQ 237 Query: 559 TKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + LI RL R L H +F Sbjct: 238 AESLIRRLLTKSPKQRITSLQALEHEWF 265 >5Z33-A nrPDB Length = 425 Score = 159 bits (402), Expect = 4e-39, Method: Composition-based stats. Identities = 59/324 (18%), Positives = 108/324 (33%), Gaps = 91/324 (28%) Query: 363 FFIDEKYKIADTSEGGIY------LGFYEKQEVAVKTFCEG------SPRAQREVSCLQS 410 F +DE+Y + G Y + + VA+K + RA RE+ LQ Sbjct: 27 FIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQH 86 Query: 411 SRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLD--VHRGEDVENEEDEFARNVLSSI 468 R + ++ Y + R F L E+ +E L + G+ + D ++ + I Sbjct: 87 FRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLT---DAHFQSFIYQI 143 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE------------ 516 ++ +H S H+DL+P N+L+++ + DF + ++ DP+E Sbjct: 144 LCGLKYIH-SANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATR 202 Query: 517 ---------------VKRDLEDLGRLVLYVVKKGSISF------EDLKA----------- 544 D+ +G +L + G F + L Sbjct: 203 WYRAPEIMLSFQSYTKAIDVWSVGC-ILAELLGGRPFFKGRDYVDQLNQILHILGTPNEE 261 Query: 545 --------QSNEEVVQLS-------------PDEETKDLIHRLFHPGEHVRDCLSDLLGH 583 ++ E V L + + DL+ R+ R + L H Sbjct: 262 TLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEH 321 Query: 584 PFFWTWESRYRTLRNVGNESDIKT 607 P+ W + +E D T Sbjct: 322 PYLHIWH-------DASDEPDCPT 338 >4CFF-A nrPDB Length = 571 Score = 159 bits (402), Expect = 4e-39, Method: Composition-based stats. Identities = 55/302 (18%), Positives = 105/302 (34%), Gaps = 49/302 (16%) Query: 369 YKIADTSEGGIYLGFYEKQ------EVAVK-------TFCEGSPRAQREVSCLQSSRENS 415 Y + DT G + + +VAVK + + +RE+ L+ R + Sbjct: 35 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR-HP 93 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 H++ Y S F+ + G E+ AR + I AV Sbjct: 94 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR----VEEMEARRLFQQILSAVDYC 149 Query: 476 HLSCGYTHQDLQPQNILIDSKKAAHLADFDKS---------IKWAGDPQEV--------- 517 H H+DL+P+N+L+D+ A +ADF S G P Sbjct: 150 HRHM-VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 208 Query: 518 ----KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLS-------PDEETKDLIHRL 566 + D+ G ++LY + G++ F+D + + ++ + L+ + Sbjct: 209 YAGPEVDIWSCG-VILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHM 267 Query: 567 FHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHS 626 R + D+ H +F Y + ++++ ++ E+ + SE Sbjct: 268 LQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVM 327 Query: 627 KS 628 S Sbjct: 328 NS 329 >3FXW-A nrPDB Length = 336 Score = 159 bits (401), Expect = 5e-39, Method: Composition-based stats. Identities = 55/274 (20%), Positives = 102/274 (37%), Gaps = 54/274 (19%) Query: 362 KFFIDEKYKIADTSEGGIYLGFY-------EKQEVAVKTFCEGSPRAQREVSCLQSSREN 414 K+ + + Y+++ G G Q+ A+K SP+A++EV + Sbjct: 23 KYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALK-LLYDSPKARQEVDHHWQASGG 81 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENE--EDEFARNVLSSIFKAV 472 H+V + H C+ + + +E R ++ ++ + A ++ I A+ Sbjct: 82 PHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAI 141 Query: 473 QELHLSCGYTHQDLQPQNILIDSKKA---AHLADFDKSIK--------WAGDPQEV---- 517 Q LH S H+D++P+N+L SK+ L DF + + P V Sbjct: 142 QFLH-SHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEV 200 Query: 518 --------KRDLEDLGRLVLYVVKKGSISFEDLKAQS-----------------NEEVVQ 552 D+ LG +++Y++ G F Q+ N E + Sbjct: 201 LGPEKYDKSCDMWSLG-VIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSE 259 Query: 553 LSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 +S D K LI L R ++ + HP+ Sbjct: 260 VSED--AKQLIRLLLKTDPTERLTITQFMNHPWI 291 >2V7O-A nrPDB Length = 336 Score = 158 bits (400), Expect = 6e-39, Method: Composition-based stats. Identities = 55/269 (20%), Positives = 98/269 (36%), Gaps = 57/269 (21%) Query: 367 EKYKIADTSEGGIYLGFYE------KQEVAVKTFCEGSPRAQREVSCLQSSR-----ENS 415 + Y++ + G + QE A K A+ + +R ++ Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 90 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 ++V + S S G ++ L + + +E D A + + I ++V + Sbjct: 91 NIVRLHDSISEEGFHYLVFDLVTGG--ELFEDIVAREYYSEAD--ASHCIHQILESVNHI 146 Query: 476 HLSCGYTHQDLQPQNILIDSKK---AAHLADFDKSIKWAG-------------------- 512 H H+DL+P+N+L+ SK A LADF +I+ G Sbjct: 147 HQ-HDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVL 205 Query: 513 --DPQEVKRDLEDLGRLVLYVVKKGSISFED-----LKAQ--------SNEEVVQLSPDE 557 DP D+ G ++LY++ G F D L Q + E ++P Sbjct: 206 RKDPYGKPVDIWACG-VILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTP-- 262 Query: 558 ETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 E K+LI+++ R L HP+ Sbjct: 263 EAKNLINQMLTINPAKRITADQALKHPWV 291 >5U6Y-A nrPDB Length = 461 Score = 158 bits (400), Expect = 7e-39, Method: Composition-based stats. Identities = 60/267 (22%), Positives = 100/267 (37%), Gaps = 57/267 (21%) Query: 369 YKIADTSEGGIYLGFYE------KQEVAVKTFCEGSPRAQREVSCLQSSR-----ENSHL 417 Y++ + G + QE A K A+ + +R ++ ++ Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 418 VTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL 477 V + S S GH ++ L + + +E D A + + I +AV H Sbjct: 62 VRLHDSISEEGHHYLIFDLVTGG--ELFEDIVAREYYSEAD--ASHCIQQILEAVLHCHQ 117 Query: 478 SCGYTHQDLQPQNILIDSK---KAAHLADFDKSIKWAG---------------------- 512 G H+DL+P+N+L+ SK A LADF +I+ G Sbjct: 118 -MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK 176 Query: 513 DPQEVKRDLEDLGRLVLYVVKKGSISFED-----LKAQ--------SNEEVVQLSPDEET 559 DP DL G ++LY++ G F D L Q + E ++P E Sbjct: 177 DPYGKPVDLWACG-VILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTP--EA 233 Query: 560 KDLIHRLFHPGEHVRDCLSDLLGHPFF 586 KDLI+++ R ++ L HP+ Sbjct: 234 KDLINKMLTINPSKRITAAEALKHPWI 260 >2VZ6-A nrPDB Length = 313 Score = 157 bits (397), Expect = 1e-38, Method: Composition-based stats. Identities = 60/267 (22%), Positives = 100/267 (37%), Gaps = 57/267 (21%) Query: 369 YKIADTSEGGIYLGFYE------KQEVAVKTFCEGSPRAQREVSCLQSSR-----ENSHL 417 Y++ + G + QE A K A+ + +R ++ ++ Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 418 VTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL 477 V + S S GH ++ L + + +E D A + + I +AV H Sbjct: 84 VRLHDSISEEGHHYLIFDLVTGG--ELFEDIVAREYYSEAD--ASHCIQQILEAVLHCHQ 139 Query: 478 SCGYTHQDLQPQNILIDSK---KAAHLADFDKSIKWAG---------------------- 512 G H+DL+P+N+L+ SK A LADF +I+ G Sbjct: 140 -MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK 198 Query: 513 DPQEVKRDLEDLGRLVLYVVKKGSISFED-----LKAQ--------SNEEVVQLSPDEET 559 DP DL G ++LY++ G F D L Q + E ++P E Sbjct: 199 DPYGKPVDLWACG-VILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTP--EA 255 Query: 560 KDLIHRLFHPGEHVRDCLSDLLGHPFF 586 KDLI+++ R ++ L HP+ Sbjct: 256 KDLINKMLTINPSKRITAAEALKHPWI 282 >5EZV-A nrPDB Length = 560 Score = 157 bits (397), Expect = 2e-38, Method: Composition-based stats. Identities = 55/302 (18%), Positives = 105/302 (34%), Gaps = 49/302 (16%) Query: 369 YKIADTSEGGIYLGFYEKQ------EVAVK-------TFCEGSPRAQREVSCLQSSRENS 415 Y + DT G + + +VAVK + + +RE+ L+ R + Sbjct: 30 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR-HP 88 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 H++ Y S F+ + G E+ AR + I AV Sbjct: 89 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR----VEEMEARRLFQQILSAVDYC 144 Query: 476 HLSCGYTHQDLQPQNILIDSKKAAHLADFDKS---------IKWAGDPQEV--------- 517 H H+DL+P+N+L+D+ A +ADF S G P Sbjct: 145 HRHM-VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 203 Query: 518 ----KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLS-------PDEETKDLIHRL 566 + D+ G ++LY + G++ F+D + + ++ + L+ + Sbjct: 204 YAGPEVDIWSCG-VILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHM 262 Query: 567 FHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHS 626 R + D+ H +F Y + ++++ ++ E+ + SE Sbjct: 263 LQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVM 322 Query: 627 KS 628 S Sbjct: 323 NS 324 >4REW-A nrPDB Length = 540 Score = 157 bits (396), Expect = 2e-38, Method: Composition-based stats. Identities = 54/299 (18%), Positives = 106/299 (35%), Gaps = 49/299 (16%) Query: 369 YKIADTSEGGIY----LGFYE--KQEVAVK-------TFCEGSPRAQREVSCLQSSRENS 415 Y + DT G + +G +E +VAVK + + +RE+ L+ R + Sbjct: 8 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFR-HP 66 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 H++ Y S +F+ + D +E++ +R + I V Sbjct: 67 HIIKLYQVISTPSDIFMVMEYVSGG--ELFDYICKNGRLDEKE--SRRLFQQILSGVDYC 122 Query: 476 HLSCGYTHQDLQPQNILIDSKKAAHLADFDKS---------IKWAGDPQEV--------- 517 H H+DL+P+N+L+D+ A +ADF S G P Sbjct: 123 HRHM-VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 181 Query: 518 ----KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVV-------QLSPDEETKDLIHRL 566 + D+ G ++LY + G++ F+D + + + + L+ + Sbjct: 182 YAGPEVDIWSSG-VILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHM 240 Query: 567 FHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEH 625 R + D+ H +F +Y + S + ++ E+ + E Sbjct: 241 LQVDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEV 299 >3SOA-A nrPDB Length = 444 Score = 157 bits (396), Expect = 2e-38, Method: Composition-based stats. Identities = 59/269 (21%), Positives = 101/269 (37%), Gaps = 57/269 (21%) Query: 367 EKYKIADTSEGGIYLGFYE------KQEVAVKTFCEGSPRAQREVSCLQSSR-----ENS 415 E+Y++ + G + QE A A+ + +R ++ Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHP 70 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 ++V + S S GH ++ L + + +E D A + + I +AV Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGG--ELFEDIVAREYYSEAD--ASHCIQQILEAVLHC 126 Query: 476 HLSCGYTHQDLQPQNILIDSK---KAAHLADFDKSIKWAG-------------------- 512 H G H++L+P+N+L+ SK A LADF +I+ G Sbjct: 127 HQ-MGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL 185 Query: 513 --DPQEVKRDLEDLGRLVLYVVKKGSISFED-----LKAQ--------SNEEVVQLSPDE 557 DP DL G ++LY++ G F D L Q + E ++P Sbjct: 186 RKDPYGKPVDLWACG-VILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTP-- 242 Query: 558 ETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 E KDLI+++ R ++ L HP+ Sbjct: 243 EAKDLINKMLTINPSKRITAAEALKHPWI 271 >5GP7-A nrPDB Length = 169 Score = 157 bits (396), Expect = 2e-38, Method: Composition-based stats. Identities = 45/154 (29%), Positives = 68/154 (44%), Gaps = 7/154 (4%) Query: 12 GPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEG-GWTPLHNAVQMS 70 GP S R + L+ A + + VQ+L N+N ++ +G TPLH A + Sbjct: 1 GPGSDLLR-----GDAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNSTPLHLAAGYN 54 Query: 71 REDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFM 130 ++ E LL HGAD + K G P AA G V + L + VN D + FT Sbjct: 55 NLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLH 114 Query: 131 EAAVYGKVKALKFLYKRGANVNLRRKTKEDQERL 164 EAA G+ + L GA+ ++ + + L Sbjct: 115 EAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDL 148 Score = 122 bits (306), Expect = 5e-28, Method: Composition-based stats. Identities = 43/157 (27%), Positives = 67/157 (42%), Gaps = 18/157 (11%) Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGF--TAFMEAAVYGKVKALKFLYKRGA 149 G + AA G + ++ ++N D G T AA Y ++ ++L + GA Sbjct: 9 GDAALLDAAKKGCLARVQKL-CTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGA 67 Query: 150 NVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHA 209 +VN + K GG L +AA GHV++ +L+ N C N Sbjct: 68 DVNAQDK----------GGLIPLHNAASYGHVDIAALLIK-----YNTCVNATDKWAFTP 112 Query: 210 LLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILA 246 L + + LLL HGAD ++ + G+TPL LA Sbjct: 113 LHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 149 Score = 114 bits (285), Expect = 1e-25, Method: Composition-based stats. Identities = 39/147 (26%), Positives = 64/147 (43%), Gaps = 5/147 (3%) Query: 168 GATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLD 227 G AL+DAA+KG + ++ L ++N D GRN+ L + + + LL+ Sbjct: 9 GDAALLDAAKKGCLARVQKLCT--PENINCRDTQGRNST--PLHLAAGYNNLEVAEYLLE 64 Query: 228 HGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKK 287 HGADVN + + G PL A H+ + L+ + + +N TD T L A + + Sbjct: 65 HGADVNAQDKGGLIPLHNAASYGHVDIAALLI-KYNTCVNATDKWAFTPLHEAAQKGRTQ 123 Query: 288 IAELLCKRGASTDCGDLVMTARRNYDH 314 + LL GA + + Sbjct: 124 LCALLLAHGADPTMKNQEGQTPLDLAT 150 Score = 111 bits (277), Expect = 1e-24, Method: Composition-based stats. Identities = 37/115 (32%), Positives = 53/115 (46%), Gaps = 1/115 (0%) Query: 19 RRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELL 78 R ++ L A ++++ + LLE GA+VN Q+ +GG PLHNA DI LL Sbjct: 37 RDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQD-KGGLIPLHNAASYGHVDIAALL 95 Query: 79 LRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAA 133 +++ K TP AA G +L L L+ GAD + G T A Sbjct: 96 IKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLAT 150 >4RED-A nrPDB Length = 351 Score = 157 bits (396), Expect = 2e-38, Method: Composition-based stats. Identities = 53/299 (17%), Positives = 105/299 (35%), Gaps = 49/299 (16%) Query: 369 YKIADTSEGGIY----LGFYE--KQEVAVK-------TFCEGSPRAQREVSCLQSSRENS 415 Y + DT G + +G +E VAVK + + +RE+ L+ R + Sbjct: 16 YILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFR-HP 74 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 H++ Y S +F+ + D +E++ +R + I V Sbjct: 75 HIIKLYQVISTPSDIFMVMEYVSGG--ELFDYICKNGRLDEKE--SRRLFQQILSGVDYC 130 Query: 476 HLSCGYTHQDLQPQNILIDSKKAAHLADFDKS---------IKWAGDPQEV--------- 517 H H+DL+P+N+L+D+ A +ADF S G P Sbjct: 131 HRHM-VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 Query: 518 ----KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVV-------QLSPDEETKDLIHRL 566 + D+ G ++LY + G++ F+D + + + + L+ + Sbjct: 190 YAGPEVDIWSSG-VILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHM 248 Query: 567 FHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEH 625 R + D+ H +F +Y + + + ++ E+ + E Sbjct: 249 LQVDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSTTMIDDEALKEVCEKFECSEEEV 307 >4CFH-A nrPDB Length = 493 Score = 155 bits (392), Expect = 6e-38, Method: Composition-based stats. Identities = 54/299 (18%), Positives = 106/299 (35%), Gaps = 49/299 (16%) Query: 369 YKIADTSEGGIY----LGFYE--KQEVAVK-------TFCEGSPRAQREVSCLQSSRENS 415 Y + DT G + +G +E +VAVK + + +RE+ L+ R + Sbjct: 35 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFR-HP 93 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 H++ Y S +F+ + D +E++ +R + I V Sbjct: 94 HIIKLYQVISTPSDIFMVMEYVSGG--ELFDYICKNGRLDEKE--SRRLFQQILSGVDYC 149 Query: 476 HLSCGYTHQDLQPQNILIDSKKAAHLADFDKS---------IKWAGDPQEV--------- 517 H H+DL+P+N+L+D+ A +ADF S G P Sbjct: 150 HRHM-VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 208 Query: 518 ----KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVV-------QLSPDEETKDLIHRL 566 + D+ G ++LY + G++ F+D + + + + L+ + Sbjct: 209 YAGPEVDIWSSG-VILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHM 267 Query: 567 FHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEH 625 R + D+ H +F +Y + S + ++ E+ + E Sbjct: 268 LQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEV 326 >5IG1-A nrPDB Length = 344 Score = 155 bits (391), Expect = 7e-38, Method: Composition-based stats. Identities = 54/264 (20%), Positives = 95/264 (35%), Gaps = 50/264 (18%) Query: 366 DEKYKIADTSEGGIYL--GFYEKQEVAVKTFCEGSPR------AQREVSCLQSSRENSHL 417 D++ I + ++ + AVK S R +RE+ SS ++ H+ Sbjct: 20 DKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGIC-SSLQHEHI 78 Query: 418 VTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL 477 V+ + H ++ D NE+D A + I A+Q H Sbjct: 79 VSMRRAFRDESHFYLVFEYVSGG--ELFDEIVTRKFYNEKD--ASACMHQILSALQHCH- 133 Query: 478 SCGYTHQDLQPQNILI---DSKKAAHLADFDKSI---------KWAGDP----------- 514 S H+DL+P+N+L+ D + DF ++ +AG P Sbjct: 134 SKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRV 193 Query: 515 -QEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLS----PDEE-------TKDL 562 + D+ G ++LY++ G F + Q ++ P E K+L Sbjct: 194 PYDTAVDVWACG-VILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKEL 252 Query: 563 IHRLFHPGEHVRDCLSDLLGHPFF 586 I + P R + +LL HP+ Sbjct: 253 IKAMLEPNPKRRPTVQELLQHPWI 276 >2YZA-A nrPDB Length = 276 Score = 155 bits (391), Expect = 7e-38, Method: Composition-based stats. Identities = 50/260 (19%), Positives = 91/260 (35%), Gaps = 49/260 (18%) Query: 369 YKIADTSEGGIYLGFYEKQ------EVAVKTF-------CEGSPRAQREVSCLQSSRENS 415 Y + DT G + + +VAVK + + +RE+ L+ R + Sbjct: 13 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR-HP 71 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 H++ Y S F+ + G E+ AR + I AV Sbjct: 72 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR----VEEMEARRLFQQILSAVDYC 127 Query: 476 HLSCGYTHQDLQPQNILIDSKKAAHLADFDKS---------IKWAGDPQEV--------- 517 H H+DL+P+N+L+D+ A +ADF S G P Sbjct: 128 HRHM-VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRL 186 Query: 518 ----KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLS-------PDEETKDLIHRL 566 + D+ G ++LY + G++ F+D + + ++ + L+ + Sbjct: 187 YAGPEVDIWSCG-VILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHM 245 Query: 567 FHPGEHVRDCLSDLLGHPFF 586 R + D+ H +F Sbjct: 246 LQVDPLKRATIKDIREHEWF 265 >3MN3-A nrPDB Length = 271 Score = 155 bits (391), Expect = 8e-38, Method: Composition-based stats. Identities = 52/255 (20%), Positives = 94/255 (36%), Gaps = 46/255 (18%) Query: 370 KIADTSEGGIYLGFYEK--QEVAVKTFCEGS-------PRAQREVSCLQSSRENSHLVTF 420 + + S G + L ++ Q+VA+K + R +RE+S L+ R + H++ Sbjct: 11 TLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLR-HPHIIKL 69 Query: 421 YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG 480 Y + + + + D D +E++ AR I AV+ H Sbjct: 70 YDVIKSKDEIIMVIEYAGN---ELFDYIVQRDKMSEQE--ARRFFQQIISAVEYCHR-HK 123 Query: 481 YTHQDLQPQNILIDSKKAAHLADFDKS---------IKWAGDPQEV-------------K 518 H+DL+P+N+L+D +ADF S G P + Sbjct: 124 IVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPE 183 Query: 519 RDLEDLGRLVLYVVKKGSISFED------LKAQSNE-EVVQLSPDEETKDLIHRLFHPGE 571 D+ G ++LYV+ + F+D K SN + LI R+ Sbjct: 184 VDVWSCG-VILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLIVNP 242 Query: 572 HVRDCLSDLLGHPFF 586 R + +++ +F Sbjct: 243 LNRISIHEIMQDDWF 257 >4UZD-A nrPDB Length = 287 Score = 154 bits (389), Expect = 1e-37, Method: Composition-based stats. Identities = 50/266 (18%), Positives = 91/266 (34%), Gaps = 47/266 (17%) Query: 367 EKYKIADTSEGGIYLGFYEKQE----------VAVKTFCEGS---PRAQREVSCLQSSRE 413 E ++I G + Y +E V K E + + +REV R Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR- 66 Query: 414 NSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQ 473 + +++ YG +++ + + + +++ ++ + A+ Sbjct: 67 HPNILRLYGYFHDATRVYLILEYAPLGT----VYRELQKLSKFDEQRTATYITELANALS 122 Query: 474 ELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS--------IKWAGDPQEV-------- 517 H S H+D++P+N+L+ S +ADF S G + Sbjct: 123 YCH-SKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR 181 Query: 518 ----KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSP-------DEETKDLIHRL 566 K DL LG ++ Y G FE Q + + E +DLI RL Sbjct: 182 MHDEKVDLWSLG-VLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRL 240 Query: 567 FHPGEHVRDCLSDLLGHPFFWTWESR 592 R L ++L HP+ S+ Sbjct: 241 LKHNPSQRPMLREVLEHPWITANSSK 266 >4I6B-A nrPDB Length = 308 Score = 154 bits (388), Expect = 2e-37, Method: Composition-based stats. Identities = 50/284 (17%), Positives = 92/284 (32%), Gaps = 50/284 (17%) Query: 352 RIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYE------KQEVAVKTFC---EGSPRAQ 402 I R ++ ++Y T G + YE + A K P + Sbjct: 16 EISRIIVDPTT---GKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQR 72 Query: 403 REVSC---LQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDE 459 ++ L + H+V FY + ++++ + C + + + + V E + Sbjct: 73 EKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSR--RSMAHILKARKVLTEPE- 129 Query: 460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKW--------- 510 R L I ++ LH H+DL+ N I+ + DF + + Sbjct: 130 -VRYYLRQIVSGLKYLHE-QEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRT 187 Query: 511 -AGDPQEV------------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVV------ 551 G P + + D+ LG ++ Y + G FE + + Sbjct: 188 ICGTPNYLSPEVLNKQGHGAESDIWALGCVM-YTMLLGRPPFETTNLKETYRSIREARYT 246 Query: 552 -QLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYR 594 S K LI + R L D++ H FF + R Sbjct: 247 MPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFTQGFTPDR 290 >4NIF-A nrPDB Length = 333 Score = 153 bits (387), Expect = 2e-37, Method: Composition-based stats. Identities = 59/276 (21%), Positives = 99/276 (35%), Gaps = 52/276 (18%) Query: 362 KFFIDEKYKIADTSEGGIYLG------FYEKQEVAVKTFCEGSPRAQREVSCLQSSRENS 415 + Y + +T G Y E AVK + E+ L ++ Sbjct: 3 NLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHP 62 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 +++T H+++ L LD + +E + A VL +I K V+ L Sbjct: 63 NIITLKDVYDDGKHVYLVTELMRGG--ELLDKILRQKFFSERE--ASFVLHTIGKTVEYL 118 Query: 476 HLSCGYTHQDLQPQNIL-IDSKKA---AHLADFDKSIKWAGD---------------PQE 516 H S G H+DL+P NIL +D + DF + + + P+ Sbjct: 119 H-SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEV 177 Query: 517 VKR-------DLEDLGRLVLYVVKKGSISF--------EDLKAQSNEEVVQLS------P 555 +KR D+ LG ++LY + G F E++ + LS Sbjct: 178 LKRQGYDEGCDIWSLG-ILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTV 236 Query: 556 DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWES 591 E KDL+ ++ H H R +L HP+ + Sbjct: 237 SETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDK 272 >3BHH-A nrPDB Length = 295 Score = 153 bits (387), Expect = 2e-37, Method: Composition-based stats. Identities = 57/271 (21%), Positives = 101/271 (37%), Gaps = 57/271 (21%) Query: 365 IDEKYKIADTSEGGIYLGFYE------KQEVAVKTFCEGSPRAQREVSCLQSSR-----E 413 + ++Y++ + G + E A K A+ + +R + Sbjct: 2 MTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLK 61 Query: 414 NSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQ 473 +S++V + S S G ++ L + + +E D A + + I +AV Sbjct: 62 HSNIVRLHDSISEEGFHYLVFDLVTGG--ELFEDIVAREYYSEAD--ASHCIQQILEAVL 117 Query: 474 ELHLSCGYTHQDLQPQNILIDSKK---AAHLADFDKSIKWAGDPQE-------------- 516 H G H+DL+P+N+L+ SK A LADF +I+ GD Q Sbjct: 118 HCHQ-MGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPE 176 Query: 517 --------VKRDLEDLGRLVLYVVKKGSISFED-----LKAQ--------SNEEVVQLSP 555 D+ G ++LY++ G F D L Q + E ++P Sbjct: 177 VLRKEAYGKPVDIWACG-VILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTP 235 Query: 556 DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 E K+LI+++ R + L HP+ Sbjct: 236 --EAKNLINQMLTINPAKRITAHEALKHPWV 264 >4B6L-A nrPDB Length = 281 Score = 151 bits (382), Expect = 8e-37, Method: Composition-based stats. Identities = 48/255 (18%), Positives = 82/255 (32%), Gaps = 38/255 (14%) Query: 369 YKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRG 428 Y+ DT G Y Q K + E+ L ++ H+V F Sbjct: 26 YEATDTETGSAYAVKVIPQSRVAK--PHQREKILNEIE-LHRDLQHRHIVRFSHHFEDAD 82 Query: 429 HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQP 488 ++++ + LC + A H + + R L I ++ LH G H+DL+ Sbjct: 83 NIYIFLELCSRKSLA----HIWKARHTLLEPEVRYYLRQILSGLKYLHQ-RGILHRDLKL 137 Query: 489 QNILIDSKKAAHLADFDKSIKW----------AGDPQEV------------KRDLEDLGR 526 N I + DF + + G P V + D+ LG Sbjct: 138 GNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGC 197 Query: 527 LVLYVVKKGSISFEDLKAQSNE-------EVVQLSPDEETKDLIHRLFHPGEHVRDCLSD 579 ++ Y + GS FE + + S + L+ + R + Sbjct: 198 VM-YTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQ 256 Query: 580 LLGHPFFWTWESRYR 594 +L H FF + R Sbjct: 257 ILRHDFFTKGYTPDR 271 >2XIK-A nrPDB Length = 294 Score = 151 bits (380), Expect = 1e-36, Method: Composition-based stats. Identities = 49/271 (18%), Positives = 101/271 (37%), Gaps = 45/271 (16%) Query: 369 YKIADTSEGGIYLGF--YEKQEVAVKTFC-----EGSPRAQREVSCLQSSRENSHLVTFY 421 +I S G +Y G + K+ VA+K + Q+E++ L ++ ++ ++ Sbjct: 25 DRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSPYITRYF 83 Query: 422 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 GS L++ + + LD+ + + E+ + +L I K + LH S Sbjct: 84 GSYLKSTKLWIIMEYLGGG--SALDLLKPGPL---EETYIATILREILKGLDYLH-SERK 137 Query: 482 THQDLQPQNILIDSKKAAHLADFDKSIKWA----------GDP------------QEVKR 519 H+D++ N+L+ + LADF + + G P + K Sbjct: 138 IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKA 197 Query: 520 DLEDLGRLVLYVVKKGSISFEDLKA--------QSNEEVVQLSPDEETKDLIHRLFHPGE 571 D+ LG + + KG DL +++ ++ + K+ + + Sbjct: 198 DIWSLGITAI-ELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDP 256 Query: 572 HVRDCLSDLLGHPFFWTWESRYRTLRNVGNE 602 R +LL H F + + L + + Sbjct: 257 RFRPTAKELLKHKFITRYTKKTSFLTELIDR 287 >2BDW-A nrPDB Length = 362 Score = 150 bits (379), Expect = 2e-36, Method: Composition-based stats. Identities = 47/275 (17%), Positives = 90/275 (32%), Gaps = 58/275 (21%) Query: 366 DEKYKIADTSEGGIYLGF-----------YEKQEVAVKTFC-EGSPRAQREVSCLQSSRE 413 + Y + + G + + + + K + +RE + + Sbjct: 28 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKL-Q 86 Query: 414 NSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQ 473 + ++V + S ++ L + + +E D A + + I +++ Sbjct: 87 HPNIVRLHDSIQEESFHYLVFDLVTGG--ELFEDIVAREFYSEAD--ASHCIQQILESIA 142 Query: 474 ELHLSCGYTHQDLQPQNILIDSKK---AAHLADFDKSIK--------------------- 509 H S G H++L+P+N+L+ SK A LADF +I+ Sbjct: 143 YCH-SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEV 201 Query: 510 WAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQ-------------SNEEVVQLSPD 556 DP D+ G ++LY++ G F D + E ++P Sbjct: 202 LKKDPYSKPVDIWACG-VILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTP- 259 Query: 557 EETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWES 591 E K LI + R L P+ E Sbjct: 260 -EAKSLIDSMLTVNPKKRITADQALKVPWICNRER 293 >3NCG-A nrPDB Length = 486 Score = 150 bits (379), Expect = 2e-36, Method: Composition-based stats. Identities = 54/279 (19%), Positives = 104/279 (37%), Gaps = 53/279 (18%) Query: 367 EKYKIADTSEGGIY------LGFYEKQEVAVKTFCEGSPRAQ------REVSCLQSSREN 414 E+Y I G + +QE AVK + S + + REV L+ ++ Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL-DH 80 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 +++ + ++ L D +E D A ++ +F + Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGG--ELFDEIIKRKRFSEHD--AARIIKQVFSGITY 136 Query: 475 LHLSCGYTHQDLQPQNILIDSK---KAAHLADFDKSIKWA---------GDPQEV----- 517 +H H+DL+P+NIL++SK + DF S + G + Sbjct: 137 MH-KHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL 195 Query: 518 ------KRDLEDLGRLVLYVVKKGSISF------EDLKAQSNE----EVVQ-LSPDEETK 560 K D+ G ++LY++ G+ F + LK ++ Q + ++ K Sbjct: 196 RGTYDEKCDVWSAG-VILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAK 254 Query: 561 DLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNV 599 DLI ++ +R + L HP+ + S T+ ++ Sbjct: 255 DLIRKMLTFHPSLRITATQCLEHPWIQKYSSETPTISDL 293 >6GU6-A nrPDB Length = 302 Score = 150 bits (378), Expect = 3e-36, Method: Composition-based stats. Identities = 60/299 (20%), Positives = 106/299 (35%), Gaps = 76/299 (25%) Query: 367 EKY----KIADTSEGGIYLGFYEK--QEVAVKTFC-----EGSPR-AQREVSCLQSSREN 414 E Y KI + + G +Y G ++ Q VA+K EG P A RE+S L+ R + Sbjct: 7 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR-H 65 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLD-VHRGEDVENEEDEFARNVLSSIFKAVQ 473 ++V+ L++ L+ LD + G+ +++ ++ L I + + Sbjct: 66 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSS---LVKSYLYQILQGIV 122 Query: 474 ELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK-----------------------W 510 H S H+DL+PQN+LID K LADF + Sbjct: 123 FCH-SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 181 Query: 511 AGDPQEVKRDLEDLGRLV--------LY----VVKKGSISFEDLKAQSNEEVVQL----- 553 D+ +G + L+ + + F L +NE ++ Sbjct: 182 GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 241 Query: 554 ------------------SPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYR 594 + DE DL+ ++ R L HP+F +++ + Sbjct: 242 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIK 300 >5CBO-A nrPDB Length = 176 Score = 149 bits (377), Expect = 3e-36, Method: Composition-based stats. Identities = 47/135 (34%), Positives = 67/135 (49%), Gaps = 9/135 (6%) Query: 15 SSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDI 74 S G++ L++A D V+ L+ GA+VN + G TPLH A +I Sbjct: 1 SDLGKK--------LLEAAHAGQDDEVRILMANGADVNAMDNFG-VTPLHLAAYWGHFEI 51 Query: 75 VELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAV 134 VE+LL++GAD G TP LAA G + ++++ L GADVN D +G TAF + Sbjct: 52 VEVLLKYGADVNASDATGDTPLHLAAKWGYLGIVEVLLKYGADVNAQDKFGKTAFDISID 111 Query: 135 YGKVKALKFLYKRGA 149 G + L K A Sbjct: 112 NGNEDLAEILCKNKA 126 Score = 134 bits (336), Expect = 2e-31, Method: Composition-based stats. Identities = 40/128 (31%), Positives = 62/128 (48%), Gaps = 10/128 (7%) Query: 63 LHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECD 122 L A ++D V +L+ +GAD G TP LAA G +++++ L GADVN D Sbjct: 7 LLEAAHAGQDDEVRILMANGADVNAMDNFGVTPLHLAAYWGHFEIVEVLLKYGADVNASD 66 Query: 123 FYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVE 182 G T AA +G + ++ L K GA+VN + K G TA + + G+ + Sbjct: 67 ATGDTPLHLAAKWGYLGIVEVLLKYGADVNAQDKF----------GKTAFDISIDNGNED 116 Query: 183 VLKILLDE 190 + +IL Sbjct: 117 LAEILCKN 124 Score = 131 bits (329), Expect = 1e-30, Method: Composition-based stats. Identities = 48/126 (38%), Positives = 70/126 (55%), Gaps = 6/126 (4%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 L++AA G + ++IL+ GADVNA DN G L A I +LL +GAD Sbjct: 7 LLEAAHAGQDDEVRILMAN-GADVNAMDNFGVTPLHLAAYWGHFE----IVEVLLKYGAD 61 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAEL 291 VN G TPL LA + +LG+V+ LL + ++N D GKTA ++++ + +AE+ Sbjct: 62 VNASDATGDTPLHLAAKWGYLGIVEVLL-KYGADVNAQDKFGKTAFDISIDNGNEDLAEI 120 Query: 292 LCKRGA 297 LCK A Sbjct: 121 LCKNKA 126 Score = 119 bits (297), Expect = 6e-27, Method: Composition-based stats. Identities = 37/127 (29%), Positives = 60/127 (47%), Gaps = 6/127 (4%) Query: 206 LIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIE 265 L LL + + + +L+ +GADVN G TPL LA H +V+ LL + + Sbjct: 3 LGKKLLEAAHAGQDDEVRILMANGADVNAMDNFGVTPLHLAAYWGHFEIVEVLL-KYGAD 61 Query: 266 INDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVM-----TARRNYDHSLVKVL 320 +N +D+ G T L LA + I E+L K GA + D + N + L ++L Sbjct: 62 VNASDATGDTPLHLAAKWGYLGIVEVLLKYGADVNAQDKFGKTAFDISIDNGNEDLAEIL 121 Query: 321 LSHGAKE 327 + A++ Sbjct: 122 CKNKAQQ 128 Score = 89.4 bits (220), Expect = 5e-18, Method: Composition-based stats. Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 1/92 (1%) Query: 26 NHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADP 85 L A ++V+ LL+ GA+VN + G TPLH A + IVE+LL++GAD Sbjct: 37 VTPLHLAAYWGHFEIVEVLLKYGADVNASDATGD-TPLHLAAKWGYLGIVEVLLKYGADV 95 Query: 86 VLRKKNGATPFILAAIAGSVKLLKLFLSKGAD 117 + K G T F ++ G+ L ++ A Sbjct: 96 NAQDKFGKTAFDISIDNGNEDLAEILCKNKAQ 127 Score = 89.4 bits (220), Expect = 5e-18, Method: Composition-based stats. Identities = 31/114 (27%), Positives = 49/114 (42%), Gaps = 12/114 (10%) Query: 243 LILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCG 302 L+ A V+ L+ ++N D+ G T L LA +I E+L K GA + Sbjct: 7 LLEAAHAGQDDEVRILMA-NGADVNAMDNFGVTPLHLAAYWGHFEIVEVLLKYGADVNAS 65 Query: 303 D------LVMTARRNYDHSLVKVLLSHG----AKEDFHPPAEDWKPQSSHWGAA 346 D L + A+ Y +V+VLL +G A++ F A D + + A Sbjct: 66 DATGDTPLHLAAKWGY-LGIVEVLLKYGADVNAQDKFGKTAFDISIDNGNEDLA 118 >3KK8-A nrPDB Length = 284 Score = 149 bits (377), Expect = 3e-36, Method: Composition-based stats. Identities = 47/275 (17%), Positives = 90/275 (32%), Gaps = 58/275 (21%) Query: 366 DEKYKIADTSEGGIYLGF-----------YEKQEVAVKTFC-EGSPRAQREVSCLQSSRE 413 + Y + + G + + + + K + +RE + + Sbjct: 5 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKL-Q 63 Query: 414 NSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQ 473 + ++V + S ++ L + + +E D A + + I +++ Sbjct: 64 HPNIVRLHDSIQEESFHYLVFDLVTGG--ELFEDIVAREFYSEAD--ASHCIQQILESIA 119 Query: 474 ELHLSCGYTHQDLQPQNILIDSKK---AAHLADFDKSIK--------------------- 509 H S G H++L+P+N+L+ SK A LADF +I+ Sbjct: 120 YCH-SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEV 178 Query: 510 WAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQ-------------SNEEVVQLSPD 556 DP D+ G ++LY++ G F D + E ++P Sbjct: 179 LKKDPYSKPVDIWACG-VILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTP- 236 Query: 557 EETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWES 591 E K LI + R L P+ E Sbjct: 237 -EAKSLIDSMLTVNPKKRITADQALKVPWICNRER 270 >1PHK-A nrPDB Length = 298 Score = 149 bits (376), Expect = 4e-36, Method: Composition-based stats. Identities = 52/257 (20%), Positives = 87/257 (33%), Gaps = 57/257 (22%) Query: 370 KIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGH 429 KI D + GG + + E +EV L+ + +++ + Sbjct: 48 KIIDVTGGGSFSA---------EEVQELREATLKEVDILRKVSGHPNIIQLKDTYETNTF 98 Query: 430 LFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQ 489 F+ L + + L + E V E E R ++ ++ + + LH H+DL+P+ Sbjct: 99 FFLVFDLMK---KGELFDYLTEKVTLSEKE-TRKIMRALLEVICALH-KLNIVHRDLKPE 153 Query: 490 NILIDSKKAAHLADFDKS---------IKWAGDPQEV------------------KRDLE 522 NIL+D L DF S + G P + + D+ Sbjct: 154 NILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPEIIECSMNDNHPGYGKEVDMW 213 Query: 523 DLGRLVLYVVKKGSISFEDLKAQ-------------SNEEVVQLSPDEETKDLIHRLFHP 569 G +++Y + GS F K + E S KDL+ R Sbjct: 214 STG-VIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDT--VKDLVSRFLVV 270 Query: 570 GEHVRDCLSDLLGHPFF 586 R + L HPFF Sbjct: 271 QPQKRYTAEEALAHPFF 287 >3D2K-A nrPDB Length = 272 Score = 149 bits (375), Expect = 6e-36, Method: Composition-based stats. Identities = 52/275 (18%), Positives = 95/275 (34%), Gaps = 47/275 (17%) Query: 358 IGKLKFFIDEKYKIADTSEGGIYLGFYEKQE----------VAVKTFCEGS---PRAQRE 404 +G + + E + I G + Y +E V KT E + + +RE Sbjct: 3 LGSKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRRE 62 Query: 405 VSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNV 464 V R + +++ YG +++ + + + +++ Sbjct: 63 VEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPLGT----VYRELQKLSRFDEQRTATY 117 Query: 465 LSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS--------IKWAGDPQE 516 ++ + A+ H S H+D++P+N+L+ S +ADF S G Sbjct: 118 ITELANALSYCH-SKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDY 176 Query: 517 V------------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSP-------DE 557 + K DL LG ++ Y G FE Q + E Sbjct: 177 LPPEMIEGRMHDEKVDLWSLG-VLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTE 235 Query: 558 ETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESR 592 +DLI RL R L+++L HP+ S+ Sbjct: 236 GARDLISRLLKHNASQRLTLAEVLEHPWIKANSSK 270 >3DFA-A nrPDB Length = 286 Score = 148 bits (374), Expect = 8e-36, Method: Composition-based stats. Identities = 53/272 (19%), Positives = 100/272 (36%), Gaps = 53/272 (19%) Query: 367 EKYKIADTSEGGIY------LGFYEKQEVAVKTFCEGSPRAQ------REVSCLQSSREN 414 E+Y I G + +QE AVK + S + + REV L+ ++ Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL-DH 80 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 +++ + ++ L D +E D A ++ +F + Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGG--ELFDEIIKRKRFSEHD--AARIIKQVFSGITY 136 Query: 475 LHLSCGYTHQDLQPQNILIDSK---KAAHLADFDKSIKWA---------GDPQEV----- 517 +H H+DL+P+NIL++SK + DF S + G + Sbjct: 137 MH-KHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL 195 Query: 518 ------KRDLEDLGRLVLYVVKKGSISF------EDLKAQSNE----EVVQ-LSPDEETK 560 K D+ G ++LY++ G+ F + LK ++ Q + ++ K Sbjct: 196 RGTYDEKCDVWSAG-VILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAK 254 Query: 561 DLIHRLFHPGEHVRDCLSDLLGHPFFWTWESR 592 DLI ++ +R + L HP+ + S Sbjct: 255 DLIRKMLTFHPSLRITATQCLEHPWIQKYSSE 286 >2BPM-A nrPDB Length = 309 Score = 148 bits (373), Expect = 1e-35, Method: Composition-based stats. Identities = 63/309 (20%), Positives = 102/309 (33%), Gaps = 75/309 (24%) Query: 356 PMIGKLKFFIDEKYKIADTSEGGIYL--GFYEKQEVAVKTF-----CEGSPR-AQREVSC 407 P++ F E KI + + G +Y + VA+K EG P A RE+S Sbjct: 2 PLVDMENFQKVE--KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISL 59 Query: 408 LQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSS 467 L+ + ++V L++ Q L+ +D + ++ L Sbjct: 60 LKEL-NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLP---LIKSYLFQ 115 Query: 468 IFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK------------------ 509 + + + H S H+DL+PQN+LI+++ A LADF + Sbjct: 116 LLQGLAFCH-SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYR 174 Query: 510 -----WAGDPQEVKRDLEDLGRLV--------LY---------------------VVKKG 535 D+ LG + L+ VV G Sbjct: 175 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 234 Query: 536 -------SISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWT 588 SF Q +VV DE+ + L+ ++ H + R L HPFF Sbjct: 235 VTSMPDYKPSFPKWARQDFSKVVP-PLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 293 Query: 589 WESRYRTLR 597 LR Sbjct: 294 VTKPVPHLR 302 >3DXN-A nrPDB Length = 287 Score = 147 bits (372), Expect = 1e-35, Method: Composition-based stats. Identities = 48/269 (17%), Positives = 93/269 (34%), Gaps = 54/269 (20%) Query: 365 IDEKY----KIADTSEGGIY--LGFYEKQEVAVKTFCEGSPRA-------QREVSCLQSS 411 + ++Y K+ + G + E A+K + S EV+ L+ Sbjct: 19 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 78 Query: 412 RENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 471 ++ +++ Y + + ++ + + D +E D A ++ + Sbjct: 79 -DHPNIMKLYEFFEDKRNYYLVMEVYRGG--ELFDEIILRQKFSEVD--AAVIMKQVLSG 133 Query: 472 VQELHLSCGYTHQDLQPQNILIDSKKA---AHLADFDKSIKWA---------GDPQEV-- 517 LH H+DL+P+N+L++SK + DF S + G + Sbjct: 134 TTYLH-KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAP 192 Query: 518 ---------KRDLEDLGRLVLYVVKKGSISF------EDLKAQSNEEVVQLSPD-----E 557 K D+ G ++LY++ G F E LK + PD + Sbjct: 193 EVLRKKYDEKCDVWSCG-VILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSD 251 Query: 558 ETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 E K L+ + R + L HP+ Sbjct: 252 EAKQLVKLMLTYEPSKRISAEEALNHPWI 280 >2QNJ-A nrPDB Length = 328 Score = 147 bits (371), Expect = 1e-35, Method: Composition-based stats. Identities = 51/282 (18%), Positives = 96/282 (34%), Gaps = 48/282 (17%) Query: 369 YKIADTSEGGIYLG------FYEKQEVAVKTFCEG------SPRAQREVSCLQSSRENSH 416 Y++ T G + +EVA+K + + REV ++ + + Sbjct: 14 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKIL-NHPN 72 Query: 417 LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 +V + L++ + V G ++ AR+ I AVQ H Sbjct: 73 IVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMK----EKEARSKFRQIVSAVQYCH 128 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK---------WAGDPQEV---------- 517 H+DL+ +N+L+D+ +ADF S + + G P Sbjct: 129 QK-RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKY 187 Query: 518 ---KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEE-------VVQLSPDEETKDLIHRLF 567 + D+ LG ++LY + GS+ F+ + E + + ++L+ R Sbjct: 188 DGPEVDVWSLG-VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFL 246 Query: 568 HPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRK 609 R L ++ + V E DI +K Sbjct: 247 VLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQK 288 >4JG6-A nrPDB Length = 355 Score = 147 bits (371), Expect = 2e-35, Method: Composition-based stats. Identities = 57/281 (20%), Positives = 102/281 (36%), Gaps = 52/281 (18%) Query: 367 EKYKIADTSEGGIYL------GFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTF 420 + Y++ + G Y E AVK + E+ L ++ +++T Sbjct: 35 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITL 94 Query: 421 YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG 480 +++V L + LD + +E + A VL +I K V+ LH + G Sbjct: 95 KDVYDDGKYVYVVTELMKGG--ELLDKILRQKFFSERE--ASAVLFTITKTVEYLH-AQG 149 Query: 481 YTHQDLQPQNIL-IDSKKA---AHLADFDKSIKWAG------DP---------------- 514 H+DL+P NIL +D + DF + + P Sbjct: 150 VVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLERQG 209 Query: 515 QEVKRDLEDLGRLVLYVVKKGSISF--------EDLKAQSNEEVVQLS------PDEETK 560 + D+ LG ++LY + G F E++ A+ LS + K Sbjct: 210 YDAACDIWSLG-VLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAK 268 Query: 561 DLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGN 601 DL+ ++ H H R + +L HP+ W+ + N + Sbjct: 269 DLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQD 309 >4YNZ-A nrPDB Length = 342 Score = 146 bits (368), Expect = 3e-35, Method: Composition-based stats. Identities = 52/282 (18%), Positives = 104/282 (36%), Gaps = 50/282 (17%) Query: 370 KIADTSEGGIYLGFY--EKQEVAVKTFCEG------SPRAQREVSCLQSSRENSHLVTFY 421 + G + LG + Q+VA+K + +RE++ L+ E+ H++ + Sbjct: 17 TLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILK-LIEHPHVLKLH 75 Query: 422 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 ++ +L++ + V +G E AR I A+ H S Sbjct: 76 DVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKE----ARKFFRQIISALDFCH-SHSI 130 Query: 482 THQDLQPQNILIDSKKAAHLADFDKSI---------KWAGDPQEV-------------KR 519 H+DL+P+N+L+D + +ADF + G P K Sbjct: 131 CHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKA 190 Query: 520 DLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQ---------LSPDEETKDLIHRLFHPG 570 D+ G ++L+ + G++ F+D + E V+ + PD + L+ + Sbjct: 191 DVWSCG-VILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPD--CQSLLRGMIEVD 247 Query: 571 EHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSES 612 R L + H ++ ++ + + + I R S Sbjct: 248 AARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQI--RSLPS 287 >3HZT-A nrPDB Length = 467 Score = 146 bits (368), Expect = 4e-35, Method: Composition-based stats. Identities = 51/274 (18%), Positives = 96/274 (35%), Gaps = 52/274 (18%) Query: 370 KIADTSEGGIY--LGFYEKQEVAVKTFCEGSPRA-------QREVSCLQSSRENSHLVTF 420 K+ + G + E A+K + S EV+ L+ ++ +++ Sbjct: 11 KLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL-DHPNIMKL 69 Query: 421 YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG 480 Y + + ++ + + D +E D A ++ + LH Sbjct: 70 YEFFEDKRNYYLVMEVYRGG--ELFDEIILRQKFSEVD--AAVIMKQVLSGTTYLH-KHN 124 Query: 481 YTHQDLQPQNILIDSKKA---AHLADFDKSIKWA---------GDPQEV----------- 517 H+DL+P+N+L++SK + DF S + G + Sbjct: 125 IVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLRKKYDE 184 Query: 518 KRDLEDLGRLVLYVVKKGSISF------EDLKAQSNEEVVQLSPD-----EETKDLIHRL 566 K D+ G ++LY++ G F E LK + PD +E K L+ + Sbjct: 185 KCDVWSCG-VILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVKLM 243 Query: 567 FHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVG 600 R + L HP+ + S+ T +VG Sbjct: 244 LTYEPSKRISAEEALNHPWIVKFCSQKHT--DVG 275 >3MA6-A nrPDB Length = 298 Score = 145 bits (367), Expect = 4e-35, Method: Composition-based stats. Identities = 49/276 (17%), Positives = 95/276 (34%), Gaps = 54/276 (19%) Query: 364 FIDEKYKIADTSEGGIY------LGFYEKQEVAVKTFCEGSPRAQ-------REVSCLQS 410 ++YK G + QE AVK + + + REV L+ Sbjct: 29 IFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQ 88 Query: 411 SRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFK 470 ++ +++ Y +G+ ++ + D +E D A ++ + Sbjct: 89 L-DHPNIMKLYEFFEDKGYFYLVGEVYTGG--ELFDEIISRKRFSEVD--AARIIRQVLS 143 Query: 471 AVQELHLSCGYTHQDLQPQNILIDSKK---AAHLADFDKSIKWA---------GDPQEV- 517 + +H + H+DL+P+N+L++SK + DF S + G + Sbjct: 144 GITYMHKN-KIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIA 202 Query: 518 ----------KRDLEDLGRLVLYVVKKGSISF-----EDLKAQSNEEVVQLSP------D 556 K D+ G ++LY++ G F D+ + + Sbjct: 203 PEVLHGTYDEKCDVWSTG-VILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVS 261 Query: 557 EETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESR 592 E KDLI ++ +R D L H + T+ Sbjct: 262 ESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKE 297 >5JN2-A nrPDB Length = 525 Score = 145 bits (367), Expect = 5e-35, Method: Composition-based stats. Identities = 51/291 (17%), Positives = 98/291 (33%), Gaps = 54/291 (18%) Query: 349 DLHRIYRPMIGKLKFFIDEKYKIADTSEGGIY------LGFYEKQEVAVKTFCEGSPRAQ 402 LH + ++YK G + QE AVK + + + Sbjct: 49 HLHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQK 108 Query: 403 -------REVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVEN 455 REV L+ ++ +++ Y +G+ ++ + D + Sbjct: 109 TDKESLLREVQLLKQL-DHPNIMKLYEFFEDKGYFYLVGEVYTGG--ELFDEIISRKRFS 165 Query: 456 EEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKK---AAHLADFDKSIKWA- 511 E D A ++ + + +H + H+DL+P+N+L++SK + DF S + Sbjct: 166 EVD--AARIIRQVLSGITYMHKN-KIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEA 222 Query: 512 --------GDPQEV-----------KRDLEDLGRLVLYVVKKGSISF-----EDLKAQSN 547 G + K D+ G ++LY++ G F D+ + Sbjct: 223 SKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTG-VILYILLSGCPPFNGANEYDILKKVE 281 Query: 548 EEVVQLSP------DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESR 592 + E KDLI ++ +R D L H + T+ Sbjct: 282 KGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKE 332 >3LIJ-A nrPDB Length = 494 Score = 145 bits (366), Expect = 5e-35, Method: Composition-based stats. Identities = 50/270 (18%), Positives = 96/270 (35%), Gaps = 49/270 (18%) Query: 359 GKLKFFIDEKYKIADTSEGGIYL--GFYEKQEVAVKTFCEGS------PRAQREVSCLQS 410 G L K+ + G + L E A+K + S + EV+ L+ Sbjct: 33 GHLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLK- 91 Query: 411 SRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFK 470 ++ +++ Y + + ++ + + +HR + + A ++ + Sbjct: 92 LLDHPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMK----FNEVDAAVIIKQVLS 147 Query: 471 AVQELHLSCGYTHQDLQPQNILIDSKKA---AHLADFDKS---------IKWAGDPQEV- 517 V LH H+DL+P+N+L++SK+ + DF S + G + Sbjct: 148 GVTYLH-KHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIA 206 Query: 518 ----------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQL------SP-----D 556 K D+ +G ++L+++ G F Q V+ SP Sbjct: 207 PEVLRKKYDEKCDVWSIG-VILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVS 265 Query: 557 EETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 E KDLI ++ R L HP+ Sbjct: 266 EGAKDLIKQMLQFDSQRRISAQQALEHPWI 295 >4FG9-A nrPDB Length = 320 Score = 144 bits (363), Expect = 1e-34, Method: Composition-based stats. Identities = 52/273 (19%), Positives = 90/273 (32%), Gaps = 53/273 (19%) Query: 360 KLKFFIDEKYKIADTSEGGIYLGFYEKQE------VAVKTFCEGSPRAQ-----REVSCL 408 K I + Y D G + ++ VA+K + + + E++ L Sbjct: 11 KQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVL 70 Query: 409 QSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 ++ ++V GHL++ + L V +G + A ++ + Sbjct: 71 HKI-KHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFY----TERDASRLIFQV 125 Query: 469 FKAVQELHLSCGYTHQDLQPQNIL---IDSKKAAHLADFDKSI---------KWAGDPQE 516 AV+ LH G H+DL+P+N+L +D ++DF S G P Sbjct: 126 LDAVKYLH-DLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGY 184 Query: 517 VK------------RDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDE------- 557 V D +G ++ Y++ G F D E + + E Sbjct: 185 VAPEVLAQKPYSKAVDCWSIG-VIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWD 243 Query: 558 ----ETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 KD I L R L HP+ Sbjct: 244 DISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276 >3NIZ-A nrPDB Length = 311 Score = 144 bits (362), Expect = 2e-34, Method: Composition-based stats. Identities = 56/291 (19%), Positives = 95/291 (32%), Gaps = 78/291 (26%) Query: 367 EKY----KIADTSEGGIYLGF-YEKQEVAVKTF-----CEGSPR-AQREVSCLQSSRENS 415 EKY K+ + + G +Y + + VA+K EG P A RE+S L+ + Sbjct: 21 EKYQKLEKVGEGTYGVVYKAKDSQGRIVALKRIRLDAEDEGIPSTAIREISLLKELH-HP 79 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 ++V+ L + E+ L+ LD E+ +D + L + + V Sbjct: 80 NIVSLIDVIHSERCLTLVFEFMEKDLKKVLD----ENKTGLQDSQIKIYLYQLLRGVAHC 135 Query: 476 HLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKW-----------------------AG 512 H H+DL+PQN+LI+S A LADF + + Sbjct: 136 HQ-HRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGS 194 Query: 513 DPQEVKRDLEDLGRLVLYVVKKGSISF---EDLKAQSNEEVVQLSPDE------------ 557 D+ +G + + G F D + +P+ Sbjct: 195 KKYSTSVDIWSIGCIFA-EMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLW 253 Query: 558 ----------------------ETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 E DL+ + + R D + HP+F Sbjct: 254 KQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYF 304 >5WAX-A nrPDB Length = 310 Score = 143 bits (360), Expect = 3e-34, Method: Composition-based stats. Identities = 53/267 (19%), Positives = 92/267 (34%), Gaps = 53/267 (19%) Query: 367 EKYKIADTSEGGIY------LGFYEKQEVAVKTFCEGSP---RAQREVSCLQSSRENSHL 417 ++Y++ G + + Q VAVK G QRE+ S + ++ Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREI-INHRSLRHPNI 69 Query: 418 VTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL 477 + F HL + + + G ++ AR + V H Sbjct: 70 IRFKEVILTPTHLAIVMEYASGGELFERICNAGR----FSEDEARFFFQQLISGVSYCH- 124 Query: 478 SCGYTHQDLQPQNILIDSKKA--AHLADFDKSIK---------WAGDPQEVK-------- 518 S H+DL+ +N L+D A + DF S G P + Sbjct: 125 SMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 184 Query: 519 -----RDLEDLGRLVLYVVKKGSISFED-LKAQSNEEVVQ------------LSPDEETK 560 D+ G + LYV+ G+ FED + ++ + +Q + E + Sbjct: 185 YDGKVADVWSCG-VTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPECQ 243 Query: 561 DLIHRLFHPGEHVRDCLSDLLGHPFFW 587 DLI R+F R + ++ HP+F Sbjct: 244 DLISRIFVANPATRITIPEIRNHPWFL 270 >2YAB-A nrPDB Length = 361 Score = 142 bits (359), Expect = 4e-34, Method: Composition-based stats. Identities = 55/288 (19%), Positives = 106/288 (36%), Gaps = 59/288 (20%) Query: 365 IDEKYKIADTSEGGIYLGFYEKQEV------AVKTFCEGSPRA----------QREVSCL 408 +++ Y I + G + + +E A K + RA +REVS L Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSIL 69 Query: 409 QSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 + + +++T + +R + + + L + E+ +E A + + I Sbjct: 70 RQVL-HPNIITLHDVYENRTDVVLILELVSGGELFDFLAQK----ESLSEEEATSFIKQI 124 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDSKK----AAHLADFDKSIKWA---------GDPQ 515 V LH H DL+P+NI++ K L DF + + G P+ Sbjct: 125 LDGVNYLHTK-KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 516 EV------------KRDLEDLGRLVLYVVKKGSISF-EDLKAQSNEEVVQLSPD------ 556 V + D+ +G ++ Y++ G+ F D K ++ + +S D Sbjct: 184 FVAPEIVNYEPLGLEADMWSIG-VITYILLSGASPFLGDTKQETLANITAVSYDFDEEFF 242 Query: 557 ----EETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVG 600 E KD I +L R + + L HP+ +++ +R Sbjct: 243 SQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDTQQAMVRRES 290 >2JC6-A nrPDB Length = 334 Score = 142 bits (357), Expect = 7e-34, Method: Composition-based stats. Identities = 48/264 (18%), Positives = 88/264 (33%), Gaps = 53/264 (20%) Query: 369 YKIADTSEGGIYLGFYEKQEVA------VKTFCEGS-----PRAQREVSCLQSSRENSHL 417 ++ +T G + +E A VK + + + E++ L+ ++ ++ Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKI-KHENI 82 Query: 418 VTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL 477 V HL++ + L V +G ++ A ++ + AV LH Sbjct: 83 VALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFY----TEKDASTLIRQVLDAVYYLHR 138 Query: 478 SCGYTHQDLQPQNILI---DSKKAAHLADFDKSI---------KWAGDPQEVK------- 518 G H+DL+P+N+L D + ++DF S G P V Sbjct: 139 -MGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQK 197 Query: 519 -----RDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDE-----------ETKDL 562 D +G ++ Y++ G F D E + + E KD Sbjct: 198 PYSKAVDCWSIG-VIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDF 256 Query: 563 IHRLFHPGEHVRDCLSDLLGHPFF 586 I L + R HP+ Sbjct: 257 IRNLMEKDPNKRYTCEQAARHPWI 280 >6EMK-G nrPDB Length = 426 Score = 142 bits (357), Expect = 7e-34, Method: Composition-based stats. Identities = 45/179 (25%), Positives = 79/179 (44%), Gaps = 14/179 (7%) Query: 96 FILAAIAGSVKLLKLFLSKGADV--NECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNL 153 A I G++ ++K L + D+ N G+++ A+ +G+ +L + G + + Sbjct: 9 LREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHDKHE 68 Query: 154 RRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSS 213 KT + G T + A KGH + L +LL + +N GR A IH + Sbjct: 69 LIKTFK--------GNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGR-APIHIACMN 119 Query: 214 DDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSD 272 D LL+ GAD+ V G TPL + +E + ++ LL + + ++D D Sbjct: 120 D---YYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVSLDDNVRD 175 Score = 107 bits (267), Expect = 2e-23, Method: Composition-based stats. Identities = 49/232 (21%), Positives = 86/232 (37%), Gaps = 18/232 (7%) Query: 23 VEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQ-EEEGGWTPLHNAVQMSREDIVELLLRH 81 E + L +A+ ++ +V++LL ++ + E GW+ LH A R I L++ Sbjct: 3 KEPSVRLREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQL 62 Query: 82 GADPVLRKKN--GATPFILAAIAGSVKLLKLFLSKGAD-VNECDFYGFTAFMEAAVYGKV 138 G D K G T LA + G + L L L + +N G A + Sbjct: 63 GHDKHELIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYY 122 Query: 139 KALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADV--N 196 + L L GA++ + G T L E G + +K+LL+E + N Sbjct: 123 QCLSLLIGVGADLWVMDTN----------GDTPLHVCLEYGSISCMKMLLNEGEVSLDDN 172 Query: 197 ACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNV--RGERGKTPLILA 246 D + A + + + G + + +TP++ A Sbjct: 173 VRDKGNWKPIDVAQTFEVGNIYSKVLKEVKKKGPPLGAGKKPSSFRTPILNA 224 Score = 74.7 bits (182), Expect = 1e-13, Method: Composition-based stats. Identities = 35/156 (22%), Positives = 58/156 (37%), Gaps = 7/156 (4%) Query: 22 AVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRH 81 + N + A+ + LL+ E G P+H A + LL+ Sbjct: 72 TFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQCLSLLIGV 131 Query: 82 GADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGA---DVNECDFYGFTAFMEAAVYG-- 136 GAD + NG TP + GS+ +K+ L++G D N D + A + Sbjct: 132 GADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVSLDDNVRDKGNWKPIDVAQTFEVG 191 Query: 137 --KVKALKFLYKRGANVNLRRKTKEDQERLRKGGAT 170 K LK + K+G + +K + + AT Sbjct: 192 NIYSKVLKEVKKKGPPLGAGKKPSSFRTPILNAKAT 227 Score = 67.0 bits (162), Expect = 3e-11, Method: Composition-based stats. Identities = 49/238 (20%), Positives = 88/238 (36%), Gaps = 24/238 (10%) Query: 172 LMDAAEKGHVEVLKILLDEMGADV-NACDNMGRNALIHALLSSDDSDVEAITHLLLDHGA 230 L +A +G++ ++K LL + N G ++L +A I L+ G Sbjct: 9 LREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHG----RYLICVYLIQLGH 64 Query: 231 DVN--VRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKI 288 D + ++ +G T + LA+ K H + LL+Q IN +G+ + +A + Sbjct: 65 DKHELIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQC 124 Query: 289 AELLCKRGASTDCGDLVMTARRNYDHS-----LVKVLLSHG--AKEDFHPPAEDWKPQSS 341 LL GA D + +K+LL+ G + +D +WKP Sbjct: 125 LSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVSLDDNVRDKGNWKPIDV 184 Query: 342 HWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSP 399 A ++ IY ++ ++K K G + + K E P Sbjct: 185 ---AQTFEVGNIYSKVLKEVK-------KKGPPLGAGKKPSSFRTPILNAKATFEDGP 232 >3Q5I-A nrPDB Length = 504 Score = 142 bits (357), Expect = 7e-34, Method: Composition-based stats. Identities = 61/360 (16%), Positives = 129/360 (35%), Gaps = 65/360 (18%) Query: 381 LGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQT 440 G Y ++ F E E+S L+ S ++ +++ + + + ++ E Sbjct: 76 KGRYSDDNKNIEKFHEE---IYNEISLLK-SLDHPNIIKLFDVFEDKKYFYLVTEFYEGG 131 Query: 441 LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKK--- 497 + +E D A N++ I + LH H+D++P+NIL+++K Sbjct: 132 --ELFEQIINRHKFDECD--AANIMKQILSGICYLH-KHNIVHRDIKPENILLENKNSLL 186 Query: 498 AAHLADFDKSIKWA---------GDPQEV-----------KRDLEDLGRLVLYVVKKGSI 537 + DF S ++ G + K D+ G +++Y++ G Sbjct: 187 NIKIVDFGLSSFFSKDYKLRDRLGTAYYIAPEVLKKKYNEKCDVWSCG-VIMYILLCGYP 245 Query: 538 SFEDLKAQSNEEVVQ-----------LSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 F Q + V+ + +E K+LI + + R + L + Sbjct: 246 PFGGQNDQDIIKKVEKGKYYFDFNDWKNISDEAKELIKLMLTYDYNKRCTAEEALNSRWI 305 Query: 587 WTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKS-----FDKWTTKINECVM 641 + + N+SD KT +R + G + +++ K TT + Sbjct: 306 KKYANNI-------NKSDQKTLCGALSNMRKFE-GSQKLAQAAILFIGSKLTTLEERKEL 357 Query: 642 KKMNKFYEKRGNFYQNT--VGDLLKFIRNLGE------HIDEEKHKKMKLKIGDPSLYFQ 693 + K +K G+ + + + +RN +++EE +K D + Y + Sbjct: 358 TDIFKKLDKNGDGQLDKKELIEGYNVLRNFKNELGELKNVEEEVDNILKEVDFDKNGYIE 417 >5ES1-A nrPDB Length = 328 Score = 141 bits (356), Expect = 8e-34, Method: Composition-based stats. Identities = 45/264 (17%), Positives = 88/264 (33%), Gaps = 48/264 (18%) Query: 369 YKIADTSEGGIYLG------FYEKQEVAVKTFCEG------SPRAQREVSCLQSSRENSH 416 Y++ T G + +EVA+K + + REV ++ + + Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMK-GLNHPN 75 Query: 417 LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 +V + L++ + V G ++ AR I AV H Sbjct: 76 IVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMK----EKEARAKFRQIVSAVHYCH 131 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK---------WAGDPQEV---------- 517 H+DL+ +N+L+D++ +ADF S + + G P Sbjct: 132 QK-NIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKY 190 Query: 518 ---KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEE-------VVQLSPDEETKDLIHRLF 567 + D+ LG ++LY + GS+ F+ + E V + + ++ R Sbjct: 191 DGPEVDIWSLG-VILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFL 249 Query: 568 HPGEHVRDCLSDLLGHPFFWTWES 591 R L ++ + Sbjct: 250 VLNPAKRCTLEQIMKDKWINIGYE 273 >4AU8-A nrPDB Length = 296 Score = 141 bits (356), Expect = 8e-34, Method: Composition-based stats. Identities = 52/284 (18%), Positives = 93/284 (32%), Gaps = 73/284 (25%) Query: 370 KIADTSEGGIYLGFYEK--QEVAVKTF-----CEGSPR-AQREVSCLQSSRENSHLVTFY 421 KI + + G ++ + + VA+K EG P A RE+ L+ ++ ++V + Sbjct: 13 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KHKNIVRLH 71 Query: 422 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 L + C+Q L+ D G+ E ++ L + K + H S Sbjct: 72 DVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDP----EIVKSFLFQLLKGLGFCH-SRNV 126 Query: 482 THQDLQPQNILIDSKKAAHLADFDKSIK-----------------------WAGDPQEVK 518 H+DL+PQN+LI+ LADF + + Sbjct: 127 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 186 Query: 519 RDLEDLGRLVLYVVKKGSISF------EDLKAQ-------SNEEVVQLS----------- 554 D+ G + + G F + LK + E+ ++ Sbjct: 187 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMY 246 Query: 555 ------------PDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + +DL+ L R + L HP+F Sbjct: 247 PATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 290 >5YKS-A nrPDB Length = 377 Score = 141 bits (355), Expect = 1e-33, Method: Composition-based stats. Identities = 50/270 (18%), Positives = 98/270 (36%), Gaps = 44/270 (16%) Query: 355 RPMIGKLKFFIDEKYKIADTSEGGIYLG--FYEKQEVAVKTFCEG------SPRAQREVS 406 R GK+ D + + L + ++VAVK + + +EV Sbjct: 27 RGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVR 86 Query: 407 CLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLS 466 C++ ++ ++V Y + L++ + L + + + E ++ A+ + Sbjct: 87 CMKLV-QHPNIVRLYEVIDTQTKLYLILEL---GDGGDMFDYIMKHEEGLNEDLAKKYFA 142 Query: 467 SIFKAVQELHLSCGYTHQDLQPQNI-LIDSKKAAHLADFDKSIKWA-------------- 511 I A+ H H+DL+P+N+ + + L DF S K+ Sbjct: 143 QIVHAISYCH-KLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAY 201 Query: 512 -------GDPQEVKR-DLEDLGRLVLYVVKKGSISFEDLKAQSNE-------EVVQLSPD 556 GD + D+ LG ++L+++ G F++ V Sbjct: 202 SAPEILLGDEYDAPAVDIWSLG-VILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVS 260 Query: 557 EETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 +E KDLI R+ R L ++ HP+ Sbjct: 261 KECKDLITRMLQRDPKRRASLEEIENHPWL 290 >5KZ7-A nrPDB Length = 346 Score = 140 bits (353), Expect = 2e-33, Method: Composition-based stats. Identities = 46/259 (17%), Positives = 89/259 (34%), Gaps = 48/259 (18%) Query: 369 YKIADTSEGGIYLG------FYEKQEVAVKTFCEG------SPRAQREVSCLQSSRENSH 416 Y++ T G + +EVAVK + + REV ++ + + Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMK-VLNHPN 93 Query: 417 LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 +V + L++ + V G ++ AR I AVQ H Sbjct: 94 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMK----EKEARAKFRQIVSAVQYCH 149 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK---------WAGDPQEV---------- 517 H+DL+ +N+L+D+ +ADF S + + G P Sbjct: 150 QKF-IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKY 208 Query: 518 ---KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEE-------VVQLSPDEETKDLIHRLF 567 + D+ LG ++LY + GS+ F+ + E + + ++L+ + Sbjct: 209 DGPEVDVWSLG-VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFL 267 Query: 568 HPGEHVRDCLSDLLGHPFF 586 R L ++ + Sbjct: 268 ILNPSKRGTLEQIMKDRWM 286 >5B2L-A nrPDB Length = 324 Score = 140 bits (353), Expect = 2e-33, Method: Composition-based stats. Identities = 53/272 (19%), Positives = 94/272 (34%), Gaps = 53/272 (19%) Query: 370 KIADTSEGGIYLGFYEK--QEVAVKTFC-----EGSPRAQREVSCLQSSRENSHLVTFYG 422 ++ + G ++ + K +AVK E + R ++ + S + ++V +G Sbjct: 24 EMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFG 83 Query: 423 SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYT 482 + +F+ + L + E +G E + ++ I KA+ L G Sbjct: 84 TFITNTDVFIAMELMGTSAEKLKKRMQG---PIPERILGKMTVA-IVKALYYLKEKHGVI 139 Query: 483 HQDLQPQNILIDSKKAAHLADFDKSIKW-------------------AGDP-------QE 516 H+D++P NIL+D + L DF S + DP + Sbjct: 140 HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD 199 Query: 517 VKRDLEDLGRLVLYVVKKGSIS-------FEDLKAQSNEEVVQLSP----DEETKDLIHR 565 ++ D+ LG + L + G FE L EE L + + + Sbjct: 200 IRADVWSLG-ISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKD 258 Query: 566 LFHPGEHVRDCLSDLLGHPFFWTWESRYRTLR 597 R + LL H F RY TL Sbjct: 259 CLTKDHRKRPKYNKLLEHSFI----KRYETLE 286 >4EQM-A nrPDB Length = 294 Score = 140 bits (352), Expect = 2e-33, Method: Composition-based stats. Identities = 55/227 (24%), Positives = 86/227 (37%), Gaps = 48/227 (21%) Query: 357 MIGKLKFFIDEKYKIADTSEGGIYLGFYEKQE------VAVKTFC-------EGSPRAQR 403 MIGK+ I+E+YKI D GG Y ++ VA+K E R +R Sbjct: 4 MIGKI---INERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFER 60 Query: 404 EVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQ-TLEACLDVHRGEDVENEEDEFAR 462 EV + ++V+ + ++ + E TL ++ H V+ A Sbjct: 61 EVHNSSQLS-HQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDT-----AI 114 Query: 463 NVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWA----------- 511 N + I ++ H H+D++PQNILIDS K + DF + + Sbjct: 115 NFTNQILDGIKHAH-DMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVL 173 Query: 512 GDPQEVK------------RDLEDLGRLVLYVVKKGSISFEDLKAQS 546 G Q D+ +G +VLY + G F A S Sbjct: 174 GTVQYFSPEQAKGEATDECTDIYSIG-IVLYEMLVGEPPFNGETAVS 219 >4YZB-A nrPDB Length = 491 Score = 139 bits (350), Expect = 5e-33, Method: Composition-based stats. Identities = 63/374 (16%), Positives = 126/374 (33%), Gaps = 75/374 (20%) Query: 366 DEKYKIADTSEGGIY------LGFYEKQEVAVKTFCEGSPRAQREVSCLQSSR------E 413 ++YK G + QE AVK + + + + L + Sbjct: 29 SDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLD 88 Query: 414 NSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQ 473 + +++ Y +G+ ++ + D +E D A ++ + + Sbjct: 89 HPNIMKLYEFFEDKGYFYLVTEVYTGG--ELFDEIISRKRFSEVD--AARIIRQVLSGIT 144 Query: 474 ELHLSCGYTHQDLQPQNILIDSKK---AAHLADFDKSIKWA---------GDPQEV---- 517 +H + H+DL+P+N+L+++K+ + DF S + G + Sbjct: 145 YMHKN-KIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEV 203 Query: 518 -------KRDLEDLGRLVLYVVKKGSISFE-----DLKAQSNEEVVQLSP------DEET 559 K D+ G ++LY++ G F D+ + + E Sbjct: 204 LHGTYDEKCDVWSTG-VILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPA 262 Query: 560 KDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQ 619 KDLI ++ +R D L H + +T + D+ + +S +R Q Sbjct: 263 KDLIRKMLAYVPTMRISARDALEHEW-------LKTTDAATDSIDVPSLESTILNIRQFQ 315 Query: 620 P----GPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHIDE 675 + K TT E V ++NK +++ + + + E Sbjct: 316 GTQKLAAAALLYMGSKLTTN-EETV--ELNKIFQRMDKNGDGQL---------DKQELME 363 Query: 676 EKHKKMKLKIGDPS 689 + MKLK D S Sbjct: 364 GYVELMKLKGEDVS 377 >2JAM-A nrPDB Length = 304 Score = 139 bits (349), Expect = 5e-33, Method: Composition-based stats. Identities = 48/257 (18%), Positives = 87/257 (33%), Gaps = 47/257 (18%) Query: 370 KIADTSEGGIY--LGFYEKQEVAVKTFCEGS----PRAQREVSCLQSSRENSHLVTFYGS 423 + + ++ + A+K + + E++ L+ ++ ++VT Sbjct: 16 VLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKI-KHENIVTLEDI 74 Query: 424 ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTH 483 H ++ + L D V E+D A V+ + AV+ LH + G H Sbjct: 75 YESTTHYYLVMQLVSGG--ELFDRILERGVYTEKD--ASLVIQQVLSAVKYLHEN-GIVH 129 Query: 484 QDLQPQNILI---DSKKAAHLADFDKSI--------KWAGDPQEVK------------RD 520 +DL+P+N+L + + DF S G P V D Sbjct: 130 RDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKPYSKAVD 189 Query: 521 LEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQL------SP-----DEETKDLIHRLFHP 569 +G ++ Y++ G F + E ++ SP E KD I L Sbjct: 190 CWSIG-VITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEK 248 Query: 570 GEHVRDCLSDLLGHPFF 586 + R L HP+ Sbjct: 249 DPNERYTCEKALSHPWI 265 >2A27-A nrPDB Length = 321 Score = 139 bits (349), Expect = 6e-33, Method: Composition-based stats. Identities = 55/288 (19%), Positives = 106/288 (36%), Gaps = 59/288 (20%) Query: 365 IDEKYKIADTSEGGIYLGFYEKQEV------AVKTFCEGSPRA----------QREVSCL 408 +++ Y I + G + + +E A K + RA +REVS L Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSIL 69 Query: 409 QSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 + + +++T + +R + + + L + E+ +E A + + I Sbjct: 70 RQVLHH-NVITLHDVYENRTDVVLILELVSGGELFDFLAQK----ESLSEEEATSFIKQI 124 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDSKK----AAHLADFDKSIKWA---------GDPQ 515 V LH H DL+P+NI++ K L DF + + G P+ Sbjct: 125 LDGVNYLHTK-KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 516 EV------------KRDLEDLGRLVLYVVKKGSISF-EDLKAQSNEEVVQLSPD------ 556 V + D+ +G ++ Y++ G+ F D K ++ + +S D Sbjct: 184 FVAPEIVNYEPLGLEADMWSIG-VITYILLSGASPFLGDTKQETLANITAVSYDFDEEFF 242 Query: 557 ----EETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVG 600 E KD I +L R + + L HP+ +++ +R Sbjct: 243 SQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRRES 290 >4QMW-A nrPDB Length = 310 Score = 138 bits (348), Expect = 8e-33, Method: Composition-based stats. Identities = 49/270 (18%), Positives = 97/270 (35%), Gaps = 45/270 (16%) Query: 370 KIADTSEGGIYLGF--YEKQEVAVKTFC-----EGSPRAQREVSCLQSSRENSHLVTFYG 422 KI S G ++ G ++ VA+K + Q+E++ L ++ ++ +YG Sbjct: 36 KIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSPYVTKYYG 94 Query: 423 SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYT 482 S L++ + L + E +E + A +L I K + LH S Sbjct: 95 SYLKDTKLWIIMEY----LGGGSALDLLEPGPLDETQIA-TILREILKGLDYLH-SEKKI 148 Query: 483 HQDLQPQNILIDSKKAAHLADFDKSIKWA----------GDP------------QEVKRD 520 H+D++ N+L+ LADF + + G P + K D Sbjct: 149 HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKAD 208 Query: 521 LEDLGRLVLYVVKKGSISFEDLKA--------QSNEEVVQLSPDEETKDLIHRLFHPGEH 572 + LG + + +G +L ++N ++ + + K+ + + Sbjct: 209 IWSLGITAI-ELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPS 267 Query: 573 VRDCLSDLLGHPFFWTWESRYRTLRNVGNE 602 R +LL H F + L + + Sbjct: 268 FRPTAKELLKHKFILRNAKKTSYLTELIDR 297 >3TAC-A nrPDB Length = 361 Score = 138 bits (347), Expect = 9e-33, Method: Composition-based stats. Identities = 46/273 (16%), Positives = 95/273 (34%), Gaps = 53/273 (19%) Query: 364 FIDEKYKIADTSEGGIYL------GFYEKQEVAVKTFCE---------GSPRAQREVSCL 408 ++ Y++ + G + Q+ AVK + +RE S Sbjct: 23 LFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASIC 82 Query: 409 QSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 ++ H+V + S G L++ + V R + + A + + I Sbjct: 83 H-MLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQI 141 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDSKKA---AHLADFDKSIKWAG------------- 512 +A++ H + H+D++P +L+ SK+ L F +I+ Sbjct: 142 LEALRYCHDN-NIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPH 200 Query: 513 ---------DPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQL---------- 553 +P D+ G ++L+++ G + F K + E +++ Sbjct: 201 FMAPEVVKREPYGKPVDVWGCG-VILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWS 259 Query: 554 SPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 E KDL+ R+ R + + L HP+ Sbjct: 260 HISESAKDLVRRMLMLDPAERITVYEALNHPWL 292 >3GUB-A nrPDB Length = 295 Score = 138 bits (347), Expect = 1e-32, Method: Composition-based stats. Identities = 55/280 (19%), Positives = 96/280 (34%), Gaps = 59/280 (21%) Query: 365 IDEKYKIADTSEGGIYLGFYEKQEV---------AVKTFCEGSPR-------AQREVSCL 408 +D+ Y + G + + +E +K S R +REVS L Sbjct: 9 VDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSIL 68 Query: 409 QSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 + ++ +++T + ++ + + L + E+ +E A L I Sbjct: 69 KEI-QHPNVITLHEVYENKTDVILIGELVAGGELFDFLA----EKESLTEEEATEFLKQI 123 Query: 469 FKAVQELHLSCGYTHQDLQPQNI-LIDSKKA---AHLADFDKSIKWA---------GDPQ 515 V LH S H DL+P+NI L+D + DF + K G P+ Sbjct: 124 LNGVYYLH-SLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPE 182 Query: 516 EV------------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDE------ 557 V + D+ +G ++ Y++ G+ F Q V E Sbjct: 183 FVAPEIVNYEPLGLEADMWSIG-VITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYF 241 Query: 558 -----ETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESR 592 KD I RL R + D L HP+ +++ Sbjct: 242 SNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQ 281 >1ZWS-A nrPDB Length = 288 Score = 137 bits (346), Expect = 1e-32, Method: Composition-based stats. Identities = 55/285 (19%), Positives = 106/285 (37%), Gaps = 59/285 (20%) Query: 365 IDEKYKIADTSEGGIYLGFYEKQEV------AVKTFCEGSPRA----------QREVSCL 408 +++ Y I + G + + +E A K + RA +REVS L Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSIL 69 Query: 409 QSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 + + +++T + +R + + + L + E+ +E A + + I Sbjct: 70 RQVLHH-NVITLHDVYENRTDVVLILELVSGGELFDFLAQK----ESLSEEEATSFIKQI 124 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDSKK----AAHLADFDKSIKWA---------GDPQ 515 V LH H DL+P+NI++ K L DF + + G P+ Sbjct: 125 LDGVNYLHTK-KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 516 EV------------KRDLEDLGRLVLYVVKKGSISF-EDLKAQSNEEVVQLSPD------ 556 V + D+ +G ++ Y++ G+ F D K ++ + +S D Sbjct: 184 FVAPEIVNYEPLGLEADMWSIG-VITYILLSGASPFLGDTKQETLANITSVSYDFDEEFF 242 Query: 557 ----EETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLR 597 E KD I +L R + + L HP+ +++ +R Sbjct: 243 SHTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVR 287 >4RGJ-A nrPDB Length = 520 Score = 137 bits (344), Expect = 2e-32, Method: Composition-based stats. Identities = 59/350 (16%), Positives = 116/350 (33%), Gaps = 72/350 (20%) Query: 364 FIDEKYKIADTSEGGIY------LGFYEKQEVAVKTFCEGSPRAQ-------REVSCLQS 410 +E+YK G + + E A+K + + + REV L+ Sbjct: 57 VFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLK- 115 Query: 411 SRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFK 470 ++ +++ Y + ++ + + R + A ++ I Sbjct: 116 MLDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKR----FYEIDAARIIKQILS 171 Query: 471 AVQELHLSCGYTHQDLQPQNILIDSKKA----AHLADFDKSIKWA---------GDPQEV 517 + +H + H+DL+P+NIL+++K + DF S + G + Sbjct: 172 GITYMHKN-NVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYI 230 Query: 518 -----------KRDLEDLGRLVLYVVKKGSISF-----EDLKAQSNEEVVQL------SP 555 K D+ G ++LY++ G F D+ + Sbjct: 231 APDVLHGTYDEKCDIWSCG-VILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKI 289 Query: 556 DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEI- 614 ++ KDLI ++ VR D L H + S+ + +I E I Sbjct: 290 SDKAKDLIKKMLMYTSAVRISARDALEHEWIKMMTSK--------DNLNIDIPSLELSIA 341 Query: 615 -LRLLQP----GPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTV 659 +R Q + K TT I+E K++ K ++K + Sbjct: 342 NIRQFQSTQKLAQAALLYMGSKLTT-IDET--KELTKIFKKMDKNGDGQL 388 >4AN9-A nrPDB Length = 301 Score = 137 bits (344), Expect = 2e-32, Method: Composition-based stats. Identities = 55/266 (20%), Positives = 98/266 (36%), Gaps = 43/266 (16%) Query: 358 IGKLKFFIDEKY-KIADTSEGGIYLGFYEKQE--VAVKTF-CEGSPRAQ----REVSCLQ 409 +G+LK EK ++ + G ++ ++ +A K E P + RE+ L Sbjct: 3 LGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLH 62 Query: 410 SSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIF 469 + ++V FYG+ G + +C+ + LD + E + ++ + Sbjct: 63 EC-NSPYIVGFYGAFYSDGEISICMEHMDGGS---LDQVLKKAGRIPEQILGKVSIA-VI 117 Query: 470 KAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS--------------------IK 509 K + L H+D++P NIL++S+ L DF S + Sbjct: 118 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPER 177 Query: 510 WAGDPQEVKRDLEDLGRLVLYVVKKGSIS------FEDLKAQSNEEVVQLSP---DEETK 560 G V+ D+ +G L L + G FE L NE +L E + Sbjct: 178 LQGTHYSVQSDIWSMG-LSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQ 236 Query: 561 DLIHRLFHPGEHVRDCLSDLLGHPFF 586 D +++ R L L+ H F Sbjct: 237 DFVNKCLIKNPAERADLKQLMVHAFI 262 >5JZN-A nrPDB Length = 280 Score = 135 bits (340), Expect = 6e-32, Method: Composition-based stats. Identities = 56/276 (20%), Positives = 99/276 (35%), Gaps = 58/276 (21%) Query: 360 KLKFFIDEKYKIADTSEGGIYLGFYE------KQEVAVKTFCEGSPRA-----QREVSCL 408 ++ I E+YK+ T G + E +E A+K + R Q EVS L Sbjct: 12 QIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSIL 71 Query: 409 QSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 + ++ ++V L++ + L + D + E D A +L ++ Sbjct: 72 RRV-KHPNIVLLIEEMDVPTELYLVMELVKGG--DLFDAITSTNKYTERD--ASGMLYNL 126 Query: 469 FKAVQELHLSCGYTHQDLQPQNILI----DSKKAAHLADFDKSI-------KWAGDPQEV 517 A++ LH S H+D++P+N+L+ D K+ L DF + G P V Sbjct: 127 ASAIKYLH-SLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYV 185 Query: 518 ------------KRDLEDLGRLVLYVVKKGSISF---EDLKAQ------------SNEEV 550 K D+ G ++ Y++ G F D + + Sbjct: 186 APEIIAETGYGLKVDIWAAG-VITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYW 244 Query: 551 VQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 +S K+LI + R +L HP+ Sbjct: 245 DNVSDS--AKELITMMLLVDVDQRFSAVQVLEHPWV 278 >3IS5-A nrPDB Length = 285 Score = 135 bits (340), Expect = 6e-32, Method: Composition-based stats. Identities = 39/268 (14%), Positives = 93/268 (34%), Gaps = 43/268 (16%) Query: 359 GKLKFFIDEKYKIADTSEGGIYLGFYEKQ--EVAVKTFCEGSPRA-----QREVSCLQSS 411 G + K K+ + G ++L E +KT + + + E+ L+ S Sbjct: 18 GTIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLK-S 76 Query: 412 RENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 471 ++ +++ + ++++ + CE V + + + ++ + A Sbjct: 77 LDHPNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNA 136 Query: 472 VQELHLSCGYTHQDLQPQNILIDSK---KAAHLADFDKSIKWAGDPQE------------ 516 + H S H+DL+P+NIL + DF + + D Sbjct: 137 LAYFH-SQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAP 195 Query: 517 --------VKRDLEDLGRLVLYVVKKGSISF-----EDLKAQSNEEVVQ-----LSPDEE 558 K D+ G ++ + + G + F E+++ ++ + + Sbjct: 196 EVFKRDVTFKCDIWSAGVVMYF-LLTGCLPFTGTSLEEVQQKATYKEPNYAVECRPLTPQ 254 Query: 559 TKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 DL+ ++ R + +L H +F Sbjct: 255 AVDLLKQMLTKDPERRPSAAQVLHHEWF 282 >6FDY-U nrPDB Length = 276 Score = 135 bits (339), Expect = 9e-32, Method: Composition-based stats. Identities = 53/266 (19%), Positives = 95/266 (35%), Gaps = 53/266 (19%) Query: 367 EKYKIADTSEGGIYLGFYEK-------QEVAVKTFCEGS------PRAQREVSCLQSSRE 413 + + + + G Y Y+ + VA+K + S E+ L+ R Sbjct: 11 DGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIR- 69 Query: 414 NSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQ 473 + H+V + ++++ + C + +H + ++ AR + + A+Q Sbjct: 70 HPHIVQLKDFQWDSDNIYLIMEFCAGG-DLSRFIHTRRILP---EKVARVFMQQLASALQ 125 Query: 474 ELHLSCGYTHQDLQPQNILIDS--KKAAHLADFDKSIK---------WAGDP-------- 514 LH +H DL+PQNIL+ S K LADF + G P Sbjct: 126 FLHE-RNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMV 184 Query: 515 ----QEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLS----------PDEETK 560 + + DL +G ++LY G F EE ++ + + + Sbjct: 185 CQRQYDARVDLWSMG-VILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCR 243 Query: 561 DLIHRLFHPGEHVRDCLSDLLGHPFF 586 DL+ RL R D HP+ Sbjct: 244 DLLQRLLERDPSRRISFQDFFAHPWV 269 >6E2O-A nrPDB Length = 295 Score = 134 bits (338), Expect = 9e-32, Method: Composition-based stats. Identities = 50/270 (18%), Positives = 99/270 (36%), Gaps = 45/270 (16%) Query: 367 EKYKIADTSEGGIYLGFYEKQEV--AVKTFCEGSPRAQREVS---CLQSSRENSHLVTFY 421 ++ + + G +Y G +V A+K E R + + L ++ ++V + Sbjct: 26 DRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYL 85 Query: 422 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 GS S G + + + + L + +++ E I + ++ LH + Sbjct: 86 GSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIG-FYTKQILEGLKYLHDNQ-I 143 Query: 482 THQDLQPQNILIDS-KKAAHLADFDKSIKWAG-DP-----------------------QE 516 H+D++ N+LI++ ++DF S + AG +P Sbjct: 144 VHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYG 203 Query: 517 VKRDLEDLGRLVLYVVKKGSISFEDLKA-----------QSNEEVVQLSPDEETKDLIHR 565 D+ LG ++ + G F +L + + E+ + S E K I + Sbjct: 204 KAADIWSLGCTII-EMATGKPPFYELGEPQAAMFKVGMFKVHPEIPE-SMSAEAKAFILK 261 Query: 566 LFHPGEHVRDCLSDLLGHPFFWTWESRYRT 595 F P R C +DLL F + +T Sbjct: 262 CFEPDPDKRACANDLLVDEFLKVSSKKKKT 291 >5XZW-A nrPDB Length = 471 Score = 134 bits (338), Expect = 1e-31, Method: Composition-based stats. Identities = 51/282 (18%), Positives = 84/282 (29%), Gaps = 61/282 (21%) Query: 359 GKLKFFIDEKYKIADTSEGGIYLGFYEK--QEVAVKTFCE-----GSPRAQREVSCLQSS 411 G K F + + + + AVK + RE+ LQ Sbjct: 192 GIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKL 251 Query: 412 RENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 471 + +V G ++ + G ++ R + I A Sbjct: 252 -NHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHG----AVGEDAGREISRQILTA 306 Query: 472 VQELHLSCGYTHQDLQPQNILI--DSKKAAHLADFDKSI---------KWAGDPQEVK-- 518 ++ +H S G +H+DL+P NILI D + DF + + G V Sbjct: 307 IKYIH-SMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPE 365 Query: 519 -----------------------RDLEDLGRLVLYVVKKGSISF-----EDLKAQS---- 546 D+ +G LV YV+ G + F + L Q Sbjct: 366 VIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLV-YVILTGHLPFSGSTQDQLYKQIGRGS 424 Query: 547 --NEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + EE +D I L + R + L HP+ Sbjct: 425 YHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWI 466 >3UDB-A nrPDB Length = 317 Score = 133 bits (334), Expect = 3e-31, Method: Composition-based stats. Identities = 50/268 (18%), Positives = 86/268 (32%), Gaps = 53/268 (19%) Query: 366 DEKYKIADTSEGGIY------LGFYEKQEVAVKTFCEGSP---RAQREVSCLQSSRENSH 416 ++Y++ G + + VAVK G +RE+ S + + Sbjct: 18 SDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKREI-INHRSLRHPN 76 Query: 417 LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 +V F HL + + + G ++ AR + V H Sbjct: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGR----FSEDEARFFFQQLISGVSYAH 132 Query: 477 LSCGYTHQDLQPQNILIDSKKA--AHLADFDKSI---------KWAGDPQEVK------- 518 + H+DL+ +N L+D A +ADF S G P + Sbjct: 133 -AMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKK 191 Query: 519 ------RDLEDLGRLVLYVVKKGSISFEDLKAQSNEEV-------------VQLSPDEET 559 D+ G + LYV+ G+ FED + N + E Sbjct: 192 EYDGKVADVWSCG-VTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPEC 250 Query: 560 KDLIHRLFHPGEHVRDCLSDLLGHPFFW 587 + LI R+F R + ++ H +F Sbjct: 251 RHLISRIFVADPAKRISIPEIRNHEWFL 278 >4FZF-B nrPDB Length = 283 Score = 133 bits (334), Expect = 3e-31, Method: Composition-based stats. Identities = 48/270 (17%), Positives = 92/270 (34%), Gaps = 45/270 (16%) Query: 370 KIADTSEGGIYLGF--YEKQEVAVKTFC-----EGSPRAQREVSCLQSSRENSHLVTFYG 422 +I S G ++ G +Q VA+K + Q+E++ L ++S++ +YG Sbjct: 15 RIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSSYVTKYYG 73 Query: 423 SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYT 482 S L++ + L ++ +L I K + LH S Sbjct: 74 SYLKGSKLWIIMEYLGGGSALDL-----LRAGPFDEFQIATMLKEILKGLDYLH-SEKKI 127 Query: 483 HQDLQPQNILIDSKKAAHLADFDKSIKWA----------GDP------------QEVKRD 520 H+D++ N+L+ + LA F + + G P + K D Sbjct: 128 HRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKAD 187 Query: 521 LEDLGRLVLYVVKKGSISFEDLKA--------QSNEEVVQLSPDEETKDLIHRLFHPGEH 572 + LG + + KG D+ ++N + + K+ I + Sbjct: 188 IWSLGITAI-ELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPS 246 Query: 573 VRDCLSDLLGHPFFWTWESRYRTLRNVGNE 602 R +LL H F + L + + Sbjct: 247 FRPTAKELLKHKFIVKNSKKTSYLTELIDR 276 >3ZUT-A nrPDB Length = 362 Score = 133 bits (334), Expect = 3e-31, Method: Composition-based stats. Identities = 48/268 (17%), Positives = 84/268 (31%), Gaps = 53/268 (19%) Query: 366 DEKYKIADTSEGGIY------LGFYEKQEVAVKTFCEGSP---RAQREVSCLQSSRENSH 416 ++Y++ G + + VAVK G +RE+ S + + Sbjct: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREI-INHRSLRHPN 76 Query: 417 LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 +V F HL + + + G ++ AR + V H Sbjct: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGR----FSEDEARFFFQQLISGVSYCH 132 Query: 477 LSCGYTHQDLQPQNILIDSKKA--AHLADFDKSIK---------WAGDPQEVK------- 518 + H+DL+ +N L+D A + F S G P + Sbjct: 133 -AMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 Query: 519 ------RDLEDLGRLVLYVVKKGSISFEDLKAQSNEEV-------------VQLSPDEET 559 D+ G + LYV+ G+ FED + N + E Sbjct: 192 EYDGKVADVWSCG-VTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPEC 250 Query: 560 KDLIHRLFHPGEHVRDCLSDLLGHPFFW 587 + LI R+F R + ++ H +F Sbjct: 251 RHLISRIFVADPAKRISIPEIRNHEWFL 278 >4KRC-A nrPDB Length = 317 Score = 133 bits (334), Expect = 3e-31, Method: Composition-based stats. Identities = 51/293 (17%), Positives = 91/293 (31%), Gaps = 75/293 (25%) Query: 370 KIADTSEGGIYLGFYEKQEV--AVKTFC----EGSPR-AQREVSCLQSSRENSHLVTFYG 422 K+ + + +Y G + V A+K EG+P A RE+S ++ ++ ++V Y Sbjct: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL-KHENIVRLYD 70 Query: 423 SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENE-EDEFARNVLSSIFKAVQELHLSCGY 481 L + + L+ +D + E + + + + H + Sbjct: 71 VIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN-KI 129 Query: 482 THQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKR---------------------- 519 H+DL+PQN+LI+ + L DF + + Sbjct: 130 LHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTS 189 Query: 520 -DLEDLGRLVLYVVKKGSISF------EDLKA--------------------QSNEEVVQ 552 D+ G +L + G F E LK + N + Q Sbjct: 190 IDIWSCGC-ILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQ 248 Query: 553 LSP---------------DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWE 590 P D D +H L +R L HP+F + Sbjct: 249 RPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYY 301 >6CMJ-A nrPDB Length = 321 Score = 133 bits (334), Expect = 4e-31, Method: Composition-based stats. Identities = 49/275 (17%), Positives = 95/275 (34%), Gaps = 61/275 (22%) Query: 368 KYKIADTSEGGI-----------YLGFYEKQEVAVKTFCEGSP------RAQREVSCLQS 410 K +I S G + Y ++ ++ + +E++ L+ Sbjct: 39 KDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEIAILKK 98 Query: 411 SRENSHLVTFYGSESH--RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 ++ ++V HL++ L Q V ++ ++ AR + Sbjct: 99 L-DHPNVVKLVEVLDDPNEDHLYMVFELVNQGP-----VMEVPTLKPLSEDQARFYFQDL 152 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD--------------- 513 K ++ LH H+D++P N+L+ +ADF S ++ G Sbjct: 153 IKGIEYLHY-QKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMA 211 Query: 514 PQEVKR----------DLEDLGRLVLYVVKKGSISFED---------LKAQSNEEVVQLS 554 P+ + D+ +G + LY G F D +K+Q+ E Q Sbjct: 212 PESLSETRKIFSGKALDVWAMG-VTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPD 270 Query: 555 PDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTW 589 E+ KDLI R+ R + ++ HP+ Sbjct: 271 IAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRH 305 >5YV8-A nrPDB Length = 298 Score = 132 bits (333), Expect = 4e-31, Method: Composition-based stats. Identities = 44/221 (19%), Positives = 83/221 (37%), Gaps = 44/221 (19%) Query: 403 REVSCLQSSRENSHLVTFYGSESH--RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEF 460 +E++ L+ ++ ++V HL++ L Q V ++ ++ Sbjct: 85 QEIAILKKL-DHPNVVKLVEVLDDPNEDHLYMVFELVNQGP-----VMEVPTLKPLSEDQ 138 Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD------- 513 AR + K ++ LH H+D++P N+L+ +ADF S ++ G Sbjct: 139 ARFYFQDLIKGIEYLHY-QKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNT 197 Query: 514 --------PQEVKR----------DLEDLGRLVLYVVKKGSISFED---------LKAQS 546 P+ + D+ +G + LY G F D +K+Q+ Sbjct: 198 VGTPAFMAPESLSETRKIFSGKALDVWAMG-VTLYCFVFGQCPFMDERIMCLHSKIKSQA 256 Query: 547 NEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFW 587 E Q E+ KDLI R+ R + ++ HP+ Sbjct: 257 LEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVT 297 >6E2G-A nrPDB Length = 727 Score = 132 bits (333), Expect = 5e-31, Method: Composition-based stats. Identities = 56/227 (24%), Positives = 97/227 (42%), Gaps = 25/227 (11%) Query: 88 RKKNGATPFILAAIAGSVK-LLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYK 146 +K+ +P +LAA +V+ L+KL +G +V++ G TA AA+Y ++A L + Sbjct: 41 QKRIWESPLLLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLME 100 Query: 147 RGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNAC-----DNM 201 + T E E G TAL A +V +++ LL GA V+A + Sbjct: 101 AAPELVFEPMTSELYE-----GQTALHIAVINQNVNLVRALLAR-GASVSARATGSVFHY 154 Query: 202 GRNALI----HALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLG---- 253 + LI H L + E I LL++HGAD+ + G T L + + + + Sbjct: 155 RPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQ 214 Query: 254 LVQRLLEQEHIE-----INDTDSDGKTALLLAVELKLKKIAELLCKR 295 + LL + + ++ G T LA + + L ++ Sbjct: 215 MYNLLLSYDGGDHLKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQK 261 Score = 122 bits (305), Expect = 7e-28, Method: Composition-based stats. Identities = 57/256 (22%), Positives = 110/256 (42%), Gaps = 29/256 (11%) Query: 60 WTPLHNAVQMSREDIVELLLR-HGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADV 118 +PL A + + + LL+ G + + G T +AA+ +++ + + ++ Sbjct: 46 ESPLLLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLMEAAPEL 105 Query: 119 -----NECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRK---TKEDQERLRKGGAT 170 + G TA A + V ++ L RGA+V+ R L G Sbjct: 106 VFEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEH 165 Query: 171 ALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGA 230 L AA G E++++L+ E GAD+ A D++G L +L + + + +LLL + Sbjct: 166 PLSFAACVGSEEIVRLLI-EHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDG 224 Query: 231 DVNVR------GERGKTPLILAVEKKHLGLVQRLL-EQEHI------------EINDTDS 271 +++ +G TP LA + ++ + Q L+ +++HI ++ + DS Sbjct: 225 GDHLKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQKRKHIQWTYGPLTSTLYDLTEIDS 284 Query: 272 DGKTALLLAVELKLKK 287 G LL + + KK Sbjct: 285 SGDDQSLLELIVTTKK 300 Score = 78.2 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 52/329 (15%), Positives = 113/329 (34%), Gaps = 57/329 (17%) Query: 153 LRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLS 212 + + +++ + ++ + L+ AA++ +V+ L LL G +V+ MG AL A L Sbjct: 30 AQSRDEQNLLQQKRIWESPLLLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAAL- 88 Query: 213 SDDSDVEAITHLLLDHGADV-----NVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEIN 267 D +L++ ++ G+T L +AV +++ LV+ LL + ++ Sbjct: 89 ---YDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVINQNVNLVRALLAR-GASVS 144 Query: 268 DTDS-------------DGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRN--- 311 + G+ L A + ++I LL + GA D + + Sbjct: 145 ARATGSVFHYRPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILI 204 Query: 312 ------YDHSLVKVLLSHGAKEDFH-----PPAEDWKPQS-----------SHWGAALKD 349 + + +LLS+ + P + P H K Sbjct: 205 LQPNKTFACQMYNLLLSYDGGDHLKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQKRKH 264 Query: 350 LHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQ 409 + Y P+ L + + + + ++ + + +P + VS Sbjct: 265 IQWTYGPLTSTLYDLTEID---SSGDDQSLLELIVTTKKREARQILDQTP-VKELVSLKW 320 Query: 410 SSRENSHLVTFYGSESHRGHLF-VCVTLC 437 ++ L+ +C T+C Sbjct: 321 KRYGRP----YFCVLGAIYVLYIICFTMC 345 Score = 69.3 bits (168), Expect = 6e-12, Method: Composition-based stats. Identities = 38/152 (25%), Positives = 58/152 (38%), Gaps = 32/152 (21%) Query: 23 VEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEG------------GWTPLHNAVQMS 70 E L AV N++V+LV+ LL GA+V+ + G PL A + Sbjct: 115 YEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVG 174 Query: 71 REDIVELLLRHGADPVLRKKNGATPFIL---------AAIAGSVKLLKLFLSKGADVN-- 119 E+IV LL+ HGAD + G T + A ++ LS + Sbjct: 175 SEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNL-----LLSYDGGDHLK 229 Query: 120 ----ECDFYGFTAFMEAAVYGKVKALKFLYKR 147 + G T F A V G + + L ++ Sbjct: 230 SLELVPNNQGLTPFKLAGVEGNIVMFQHLMQK 261 >2J90-A nrPDB Length = 304 Score = 132 bits (332), Expect = 5e-31, Method: Composition-based stats. Identities = 50/275 (18%), Positives = 101/275 (36%), Gaps = 59/275 (21%) Query: 364 FIDEKYKIADTSEGGIYLGFYEKQEV---------AVKTFCEGSPR-------AQREVSC 407 +++ Y++ + G + + ++ +K S R +REV+ Sbjct: 23 MVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNI 82 Query: 408 LQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSS 467 L+ R + +++T + ++ + + + L + E+ ++ A L Sbjct: 83 LREIR-HPNIITLHDIFENKTDVVLILELVSGGELFDFLA----EKESLTEDEATQFLKQ 137 Query: 468 IFKAVQELHLSCGYTHQDLQPQNILIDSKK----AAHLADFDKSIKWA---------GDP 514 I V LH S H DL+P+NI++ K L DF + K G P Sbjct: 138 ILDGVHYLH-SKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTP 196 Query: 515 QEV------------KRDLEDLGRLVLYVVKKGSISF-EDLKAQSNEEVVQLSPD----- 556 + V + D+ +G ++ Y++ G+ F + K ++ + ++ D Sbjct: 197 EFVAPEIVNYEPLGLEADMWSIG-VITYILLSGASPFLGETKQETLTNISAVNYDFDEEY 255 Query: 557 -----EETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 E KD I RL R ++ L H + Sbjct: 256 FSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWI 290 >3UC3-A nrPDB Length = 361 Score = 131 bits (330), Expect = 8e-31, Method: Composition-based stats. Identities = 51/268 (19%), Positives = 84/268 (31%), Gaps = 53/268 (19%) Query: 366 DEKYKIADTSEGGIY------LGFYEKQEVAVKTFCEGS---PRAQREVSCLQSSRENSH 416 ++Y G + K+ VAVK G+ QRE+ S + + Sbjct: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREI-INHRSLRHPN 77 Query: 417 LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 +V F HL + + R + ++ AR + V H Sbjct: 78 IVRFKEVILTPTHLAIIMEYASGGE----LYERICNAGRFSEDEARFFFQQLLSGVSYCH 133 Query: 477 LSCGYTHQDLQPQNILIDSKKA--AHLADFDKSIK---------WAGDPQEVK------- 518 S H+DL+ +N L+D A + DF S G P + Sbjct: 134 -SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 Query: 519 ------RDLEDLGRLVLYVVKKGSISFED-------------LKAQSNEEVVQLSPDEET 559 D+ G + LYV+ G+ FED + + + E Sbjct: 193 EYDGKIADVWSCG-VTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPEC 251 Query: 560 KDLIHRLFHPGEHVRDCLSDLLGHPFFW 587 LI R+F R + ++ H +F Sbjct: 252 CHLISRIFVADPATRISIPEIKTHSWFL 279 >2W4O-A nrPDB Length = 349 Score = 130 bits (328), Expect = 1e-30, Method: Composition-based stats. Identities = 47/269 (17%), Positives = 88/269 (32%), Gaps = 47/269 (17%) Query: 359 GKLKFFIDEKYKIADTSEGGIY----LGFYEKQEVAVKTFCEGSPRAQREVSCLQSSREN 414 L F + + ++ + +Y G + + V + E+ L + Sbjct: 49 DALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLS-H 107 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 +++ + + + L V +G + A + + I +AV Sbjct: 108 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYY----SERDAADAVKQILEAVAY 163 Query: 475 LHLSCGYTHQDLQPQNILIDS---KKAAHLADFDKSI---------KWAGDPQEV----- 517 LH + G H+DL+P+N+L + +ADF S G P Sbjct: 164 LHEN-GIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEIL 222 Query: 518 -------KRDLEDLGRLVLYVVKKGSISFED-------LKAQSNEEVVQLSP-----DEE 558 + D+ +G ++ Y++ G F D + N E +SP Sbjct: 223 RGCAYGPEVDMWSVG-IITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLN 281 Query: 559 TKDLIHRLFHPGEHVRDCLSDLLGHPFFW 587 KDL+ +L R L HP+ Sbjct: 282 AKDLVRKLIVLDPKKRLTTFQALQHPWVT 310 >2HAK-A nrPDB Length = 328 Score = 130 bits (328), Expect = 2e-30, Method: Composition-based stats. Identities = 47/259 (18%), Positives = 89/259 (34%), Gaps = 48/259 (18%) Query: 369 YKIADTSEGGIYLGF------YEKQEVAVKTFCEG------SPRAQREVSCLQSSRENSH 416 Y++ T G + +EVAVK + + REV ++ + + Sbjct: 17 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKIL-NHPN 75 Query: 417 LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 +V + L++ + V G ++ AR I AVQ H Sbjct: 76 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMK----EKEARAKFRQIVSAVQYCH 131 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK---------WAGDPQEV---------- 517 H+DL+ +N+L+D +ADF S + + G P Sbjct: 132 QKY-IVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKY 190 Query: 518 ---KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEE-------VVQLSPDEETKDLIHRLF 567 + D+ LG ++LY + GS+ F+ + E + + ++L+ +L Sbjct: 191 DGPEVDVWSLG-VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLL 249 Query: 568 HPGEHVRDCLSDLLGHPFF 586 R L ++ + Sbjct: 250 VLNPIKRGSLEQIMKDRWM 268 >6C9D-A nrPDB Length = 459 Score = 130 bits (328), Expect = 2e-30, Method: Composition-based stats. Identities = 47/259 (18%), Positives = 89/259 (34%), Gaps = 48/259 (18%) Query: 369 YKIADTSEGGIYLGF------YEKQEVAVKTFCEG------SPRAQREVSCLQSSRENSH 416 Y++ T G + +EVAVK + + REV ++ + + Sbjct: 23 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKIL-NHPN 81 Query: 417 LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 +V + L++ + V G ++ AR I AVQ H Sbjct: 82 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMK----EKEARAKFRQIVSAVQYCH 137 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSI---------KWAGDPQEV---------- 517 H+DL+ +N+L+D +ADF S ++ G P Sbjct: 138 QKY-IVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKY 196 Query: 518 ---KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEE-------VVQLSPDEETKDLIHRLF 567 + D+ LG ++LY + GS+ F+ + E + + ++L+ +L Sbjct: 197 DGPEVDVWSLG-VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLL 255 Query: 568 HPGEHVRDCLSDLLGHPFF 586 R L ++ + Sbjct: 256 VLNPIKRGSLEQIMKDRWM 274 >2HW6-A nrPDB Length = 307 Score = 130 bits (328), Expect = 2e-30, Method: Composition-based stats. Identities = 54/295 (18%), Positives = 93/295 (31%), Gaps = 80/295 (27%) Query: 366 DEKYKIADTSEG-GIYL------GFYEKQEVAVKTFCEGS----PRAQREVSCLQSSREN 414 ++ YK+ G G Y +E AVK + + R REV L + N Sbjct: 11 EDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGN 70 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 +++ ++ L+ + + ++ + A V+ + A+ Sbjct: 71 KNILELIEFFEDDTRFYLVFE----KLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 126 Query: 475 LHLSCGYTHQDLQPQNILIDSK---KAAHLADFDKSIKW----AGDP------------- 514 LH G H+DL+P+NIL +S + DFD + P Sbjct: 127 LHTK-GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA 185 Query: 515 -----------------QEVKRDLEDLGRLVLYVVKKGSIS------------------- 538 + + DL LG +VLY++ G Sbjct: 186 EYMAPEVVEVFTDQATFYDKRCDLWSLG-VVLYIMLSGYPPFVGHCGADCGWDRGEVCRV 244 Query: 539 -----FEDLKAQS--NEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 FE ++ + E KDLI +L R + +L HP+ Sbjct: 245 CQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 299 >4PDS-A nrPDB Length = 347 Score = 130 bits (327), Expect = 2e-30, Method: Composition-based stats. Identities = 47/282 (16%), Positives = 83/282 (29%), Gaps = 61/282 (21%) Query: 359 GKLKFFIDEKYKIADTSEGGIYLGF-------YEKQEVAVKTFCEGSPRAQREVSCLQSS 411 G K F + + + + + ++ + RE+ LQ Sbjct: 27 GIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKL 86 Query: 412 RENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 471 + +V G ++ + G ++ R + I A Sbjct: 87 -NHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHG----AVGEDAGREISRQILTA 141 Query: 472 VQELHLSCGYTHQDLQPQNILI--DSKKAAHLADFDKSI---------KWAGDPQEVK-- 518 ++ +H S G +H+DL+P NILI D + F + + G V Sbjct: 142 IKYIH-SMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPE 200 Query: 519 -----------------------RDLEDLGRLVLYVVKKGSISF-----EDLKAQS---- 546 D+ +G LV YV+ G + F + L Q Sbjct: 201 VIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLV-YVILTGHLPFSGSTQDQLYKQIGRGS 259 Query: 547 --NEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + EE +D I L + R + L HP+ Sbjct: 260 YHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWI 301 >2YCR-A nrPDB Length = 323 Score = 130 bits (327), Expect = 2e-30, Method: Composition-based stats. Identities = 55/295 (18%), Positives = 103/295 (34%), Gaps = 62/295 (21%) Query: 370 KIADTSEGGIYLGFYEK--QEVAVKTFCE-----GSPR-------AQREVSCLQSSRENS 415 + + G + L F K ++VA+K + GS R + E+ L+ + Sbjct: 17 TLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKL-NHP 75 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 ++ ++ + L E D G ++ + + AVQ L Sbjct: 76 CIIKIKN-FFDAEDYYIVLELMEGG--ELFDKVVGNKRL--KEATCKLYFYQMLLAVQYL 130 Query: 476 HLSCGYTHQDLQPQNILIDSKKA---AHLADFDKSI---------KWAGDPQEVK----- 518 H + G H+DL+P+N+L+ S++ + DF S G P + Sbjct: 131 HEN-GIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLV 189 Query: 519 ----------RDLEDLGRLVLYVVKKGSISFEDLKAQSN------------EEVVQLSPD 556 D LG ++L++ G F + + Q + V Sbjct: 190 SVGTAGYNRAVDCWSLG-VILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVS 248 Query: 557 EETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSE 611 E+ DL+ +L R + L HP+ E R +++ +E + T K + Sbjct: 249 EKALDLVKKLLVVDPKARFTTEEALRHPWLQD-EDMKRKFQDLLSEENESTAKPQ 302 >1FOT-A nrPDB Length = 318 Score = 130 bits (326), Expect = 3e-30, Method: Composition-based stats. Identities = 58/343 (16%), Positives = 117/343 (34%), Gaps = 77/343 (22%) Query: 367 EKYKIADTSEGGIY------LGFYEKQEVAVKTFCEGSPRAQREVS------CLQSSREN 414 + ++I T G + + + A+K + ++V + S + Sbjct: 6 QDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTH 65 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 ++ +G+ +F+ + E E + + + N A+ + + A++ Sbjct: 66 PFIIRMWGTFQDAQQIFMIMDYIEGG-ELFSLLRKSQRFPNP---VAKFYAAEVCLALEY 121 Query: 475 LHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI-------KWAGDPQEV---------- 517 LH S ++DL+P+NIL+D + DF + G P + Sbjct: 122 LH-SKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPY 180 Query: 518 --KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVV-----QLSP--DEETKDLIHRLFH 568 D G +++Y + G F D E + + P +E+ KDL+ RL Sbjct: 181 NKSIDWWSFG-ILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLIT 239 Query: 569 PGEHVRD-----CLSDLLGHPFF--WTWESRYRTLRNVGNESDIKTRKSESEILRLLQPG 621 R D+ HP+F WE +R E+ +Q G Sbjct: 240 RDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLL-------------SRNIETPYEPPIQQG 286 Query: 622 PSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLK 664 + T++ ++ + +N G ++ DL + Sbjct: 287 QGD--------TSQFDKYPEEDIN-----YGVQGEDPYADLFR 316 >5D7A-A nrPDB Length = 308 Score = 130 bits (326), Expect = 3e-30, Method: Composition-based stats. Identities = 46/286 (16%), Positives = 99/286 (34%), Gaps = 51/286 (17%) Query: 371 IADTSEGGIYLGFYEK--QEVAVKTFC---EGSPRAQREVSCLQSSRENSHLVTFYGSES 425 + + + G +Y G + K Q A+K + ++E++ L+ + ++ T+YG+ Sbjct: 25 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFI 84 Query: 426 H------RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSC 479 L++ + C + D+ + ++E+ + I + + LH Sbjct: 85 KKNPPGMDDQLWLVMEFCGAG--SVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ-H 141 Query: 480 GYTHQDLQPQNILIDSKKAAHLADFDKSIKWA----------GDP--------------- 514 H+D++ QN+L+ L DF S + G P Sbjct: 142 KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD 201 Query: 515 --QEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSP---------DEETKDLI 563 + K DL LG + + +G+ D+ ++ +P ++ + I Sbjct: 202 ATYDFKSDLWSLGITAI-EMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFI 260 Query: 564 HRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRK 609 R L+ HPF + + + + D +K Sbjct: 261 ESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKK 306 >5KCV-A nrPDB Length = 460 Score = 129 bits (324), Expect = 4e-30, Method: Composition-based stats. Identities = 65/341 (19%), Positives = 111/341 (32%), Gaps = 57/341 (16%) Query: 325 AKEDFHP-PAEDWKPQSSHWGAALKDLHRI------YRPMIGKLKFFIDEKYKIADTSEG 377 A+ DF D + K HR+ Y ++GK F + + + + G Sbjct: 130 AEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTF--GKVILVKEKATG 187 Query: 378 GIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLC 437 Y K+EV V + E LQ+SR + L S L + Sbjct: 188 RYYAMKILKKEVIVAK--DEVAHTLTENRVLQNSR-HPFLTALKYSFQTHDRLCFVMEYA 244 Query: 438 EQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKK 497 L H + ED AR + I A+ LH ++DL+ +N+++D Sbjct: 245 NGG---ELFFHLSRERVFSEDR-ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG 300 Query: 498 AAHLADFDKSIK----------WAGDPQEV------------KRDLEDLGRLVLYVVKKG 535 + DF + + G P+ + D LG +V+Y + G Sbjct: 301 HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLG-VVMYEMMCG 359 Query: 536 SISFEDLKAQSNEEVV-------QLSPDEETKDLIHRLFHPGEHVRD-----CLSDLLGH 583 + F + + E++ + E K L+ L R +++ H Sbjct: 360 RLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 419 Query: 584 PFF----WTW--ESRYRTLRNVGNESDIKTRKSESEILRLL 618 FF W E + S+ TR + E + Sbjct: 420 RFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQM 460 >6QAU-A nrPDB Length = 280 Score = 128 bits (322), Expect = 7e-30, Method: Composition-based stats. Identities = 50/272 (18%), Positives = 95/272 (34%), Gaps = 55/272 (20%) Query: 363 FFIDEKYKIADTSEGGIYLGFYEKQ---EVAVKTFCEG-SPRAQ----REVSCLQSSREN 414 F ++ + + ++ G + ++ EVA+K+ + ++Q +E+ L+ ++ Sbjct: 11 FEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKEL-QH 69 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 ++V Y + +F+ + C A + ++ R L I A++ Sbjct: 70 ENIVALYDVQELPNSVFLVMEYCNGGDLADYL----QAKGTLSEDTIRVFLHQIAAAMRI 125 Query: 475 LHLSCGYTHQDLQPQNILIDSKK---------AAHLADFDK---------SIKWAGDP-- 514 LH S G H+DL+PQNIL+ +ADF + G P Sbjct: 126 LH-SKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMY 184 Query: 515 ----------QEVKRDLEDLGRLVLYVVKKGSISFED----------LKAQSNEEVVQLS 554 + K DL +G ++ Y G F+ K +S + Sbjct: 185 MAPEVIMSQHYDAKADLWSIGTVI-YQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRE 243 Query: 555 PDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 +L+ L + R HPF Sbjct: 244 TSPYLANLLLGLLQRNQKDRMDFEAFFSHPFL 275 >3MV5-A nrPDB Length = 342 Score = 127 bits (320), Expect = 1e-29, Method: Composition-based stats. Identities = 54/288 (18%), Positives = 94/288 (32%), Gaps = 48/288 (16%) Query: 371 IADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHL 430 + + + G Y K+EV V + E LQ+SR + L S L Sbjct: 29 VKEKATGRYYAMKILKKEVIVAK--DEVAHTLTENRVLQNSR-HPFLTALKYSFQTHDRL 85 Query: 431 FVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQN 490 + L H + ED AR + I A+ LH ++DL+ +N Sbjct: 86 CFVMEYANGG---ELFFHLSRERVFSEDR-ARFYGAEIVSALDYLHSEKNVVYRDLKLEN 141 Query: 491 ILIDSKKAAHLADFDKSIK----------WAGDPQEV------------KRDLEDLGRLV 528 +++D + DF + + G P+ + D LG +V Sbjct: 142 LMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLG-VV 200 Query: 529 LYVVKKGSISFEDLKAQSNEEVV-------QLSPDEETKDLIHRLFHPGEHVRD-----C 576 +Y + G + F + + E++ + E K L+ L R Sbjct: 201 MYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSED 260 Query: 577 LSDLLGHPFF----WTW--ESRYRTLRNVGNESDIKTRKSESEILRLL 618 +++ H FF W E + S+ TR + E + Sbjct: 261 AKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQM 308 >4APC-A nrPDB Length = 350 Score = 127 bits (319), Expect = 2e-29, Method: Composition-based stats. Identities = 52/289 (17%), Positives = 103/289 (35%), Gaps = 47/289 (16%) Query: 361 LKFFIDEKY----KIADTSEGGI--YLGFYEKQEVAVKTF------CEGSPRAQREVSCL 408 L F EKY KI + S G + ++ +K + ++REV+ L Sbjct: 18 LYFQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVL 77 Query: 409 QSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 + ++ ++V + S G L++ + CE + +++ + I Sbjct: 78 ANM-KHPNIVQYRESFEENGSLYIVMDYCEGG--DLFKRINAQKGVLFQEDQILDWFVQI 134 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWA----------GDPQEV- 517 A++ +H H+D++ QNI + L DF + G P + Sbjct: 135 CLALKHVH-DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLS 193 Query: 518 -----------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNE--------EVVQLSPDEE 558 K D+ LG + LY + +FE ++ V L + Sbjct: 194 PEICENKPYNNKSDIWALGCV-LYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYD 252 Query: 559 TKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKT 607 + L+ +LF R ++ +L F ++ + + + E +KT Sbjct: 253 LRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKT 301 >2XNP-A nrPDB Length = 279 Score = 127 bits (319), Expect = 2e-29, Method: Composition-based stats. Identities = 52/269 (19%), Positives = 104/269 (38%), Gaps = 50/269 (18%) Query: 367 EKYKIADTSEGGIY------LGFYEKQEVAVKTFCEGS------PRAQREVSCLQSSREN 414 E Y++ T G Y + + + K GS EV+ L+ ++ Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLREL-KH 64 Query: 415 SHLVTFYG--SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAV 472 ++V +Y + L++ + CE A + ++ + ++EF V++ + A+ Sbjct: 65 PNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLAL 124 Query: 473 QELHLS----CGYTHQDLQPQNILIDSKKAAHLADFDK----------SIKWAGDPQEV- 517 +E H H+DL+P N+ +D K+ L DF + + G P + Sbjct: 125 KECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMS 184 Query: 518 -----------KRDLEDLGRLVLYVVKKGSISF-----EDLKAQSNEEVVQLSP---DEE 558 K D+ LG L LY + F ++L + E + P +E Sbjct: 185 PEQMNRMSYNEKSDIWSLGCL-LYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDE 243 Query: 559 TKDLIHRLFHPGEHVRDCLSDLLGHPFFW 587 ++I R+ + ++ R + ++L +P Sbjct: 244 LNEIITRMLNLKDYHRPSVEEILENPLIL 272 >3I6U-A nrPDB Length = 419 Score = 127 bits (319), Expect = 2e-29, Method: Composition-based stats. Identities = 45/261 (17%), Positives = 88/261 (33%), Gaps = 49/261 (18%) Query: 383 FYEKQEVAVKTFCEGSP--RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQT 440 K++ A+ + E P + E+ L+ + ++ ++ + L E Sbjct: 167 IISKRKFAIGSAREADPALNVETEIEILKKL-NHPCIIKIKN-FFDAEDYYIVLELMEGG 224 Query: 441 LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA-- 498 D G ++ + + AVQ LH + G H+DL+P+N+L+ S++ Sbjct: 225 --ELFDKVVGNKRL--KEATCKLYFYQMLLAVQYLHEN-GIIHRDLKPENVLLSSQEEDC 279 Query: 499 -AHLADFDKSI---------KWAGDPQEVK---------------RDLEDLGRLVLYVVK 533 + DF S G P + D LG ++L++ Sbjct: 280 LIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLG-VILFICL 338 Query: 534 KGSISFEDLKAQSN------------EEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLL 581 G F + + Q + V E+ DL+ +L R + L Sbjct: 339 SGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEAL 398 Query: 582 GHPFFWTWESRYRTLRNVGNE 602 HP+ + + + + E Sbjct: 399 RHPWLQDEDMKRKFQDLLSEE 419 >2BRG-A nrPDB Length = 297 Score = 126 bits (317), Expect = 3e-29, Method: Composition-based stats. Identities = 49/266 (18%), Positives = 94/266 (35%), Gaps = 53/266 (19%) Query: 367 EKYKIADTSEGGIY------LGFYEKQEVAVKTFC-----EGSPRAQREVSCLQSSRENS 415 E + + T G Y + ++ VAVK + ++E+ C+ + Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEI-CINKMLNHE 65 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 ++V FYG ++ + C D + E D A+ + V L Sbjct: 66 NVVKFYGHRREGNIQYLFLEYCSGG--ELFDRIEPDIGMPEPD--AQRFFHQLMAGVVYL 121 Query: 476 HLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI------------KWAGD-----PQEVK 518 H G TH+D++P+N+L+D + ++DF + K G P+ +K Sbjct: 122 HG-IGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK 180 Query: 519 R--------DLEDLGRLVLYVVKKGSISFE----------DLKAQSNEEVVQLSPDEETK 560 R D+ G +VL + G + ++ D K + D Sbjct: 181 RREFHAEPVDVWSCG-IVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPL 239 Query: 561 DLIHRLFHPGEHVRDCLSDLLGHPFF 586 L+H++ R + D+ ++ Sbjct: 240 ALLHKILVENPSARITIPDIKKDRWY 265 >5J5T-A nrPDB Length = 370 Score = 126 bits (317), Expect = 3e-29, Method: Composition-based stats. Identities = 55/285 (19%), Positives = 93/285 (32%), Gaps = 57/285 (20%) Query: 367 EKYKIADTSEGGIYLGFYEKQEV------AVKTFC----EGSPRAQREVSCLQSSRENSH 416 E +++ G Y Y+ + V A+K E Q+E+ ++ ++ + Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDC-KHPN 62 Query: 417 LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 +V ++GS R L++C+ C + G E + A V + + LH Sbjct: 63 IVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTG---PLSELQIA-YVSRETLQGLYYLH 118 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWA----------GDPQEVK-------- 518 S G H+D++ NIL+ LADF S + G P + Sbjct: 119 -SKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVER 177 Query: 519 -------RDLEDLGRLVLYVVKKGSISFEDLK--------AQSNEEVVQLSP----DEET 559 DL +G + + + DL +SN + +L Sbjct: 178 KGGYNQLCDLWAVGITAI-ELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSF 236 Query: 560 KDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESR---YRTLRNVGN 601 + R LL HPF +R L V N Sbjct: 237 HHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNN 281 >1V0B-A nrPDB Length = 288 Score = 126 bits (317), Expect = 3e-29, Method: Composition-based stats. Identities = 55/290 (18%), Positives = 96/290 (33%), Gaps = 77/290 (26%) Query: 367 EKY----KIADTSEGGIYLGFYE-KQEVAVKTF-----CEGSPRA-QREVSCLQSSRENS 415 EKY KI + + G +Y + A+K EG P RE+S L+ ++S Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKEL-KHS 60 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 ++V Y + L + +Q L+ LDV G E A++ L + + Sbjct: 61 NIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEG----GLESVTAKSFLLQLLNGIAYC 116 Query: 476 HLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKW-----------------------AG 512 H H+DL+PQN+LI+ + +ADF + + Sbjct: 117 H-DRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGS 175 Query: 513 DPQEVKRDLEDLGRLVLYVVKKGSISF----------------EDLKAQSNEEVVQLS-- 554 D+ +G + + G+ F +++ V +L Sbjct: 176 KKYSTTIDIWSVGCIFA-EMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKY 234 Query: 555 ------------------PDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 DE DL+ ++ + R L H +F Sbjct: 235 DPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYF 284 >4KS7-A nrPDB Length = 292 Score = 126 bits (316), Expect = 4e-29, Method: Composition-based stats. Identities = 53/267 (19%), Positives = 101/267 (37%), Gaps = 46/267 (17%) Query: 359 GKLKFFIDEKYKIADTSEGGIYLGF--YEKQEVAVKTFCEGSPRAQREV----SCLQSSR 412 G + +D KI + S G + L + ++VAVK + + +RE+ + Sbjct: 19 GDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMM-DLRKQQRRELLFNEVVIMRDY 77 Query: 413 ENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAV 472 ++ ++V Y S L+V + + L + NEE V ++ +A+ Sbjct: 78 QHFNVVEMYKSYLVGEELWVLMEFLQGGA---LTDIVSQVRLNEEQIA--TVCEAVLQAL 132 Query: 473 QELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD---------------PQEV 517 LH + G H+D++ +IL+ L+DF + + D P+ + Sbjct: 133 AYLH-AQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI 191 Query: 518 KR-------DLEDLGRLVLYVVKKGSISF------EDLKAQSNEEVVQLSP----DEETK 560 R D+ LG +V+ +V G + + +K + +L + Sbjct: 192 SRSLYATEVDIWSLGIMVIEMVD-GEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLR 250 Query: 561 DLIHRLFHPGEHVRDCLSDLLGHPFFW 587 D + R+ R +LL HPF Sbjct: 251 DFLERMLVRDPQERATAQELLDHPFLL 277 >6HXF-B nrPDB Length = 302 Score = 126 bits (316), Expect = 4e-29, Method: Composition-based stats. Identities = 52/273 (19%), Positives = 93/273 (34%), Gaps = 53/273 (19%) Query: 366 DEKYKIADTSEGGIYLGFYEKQEV------AVKTFCEGSPRAQR----EVSCLQSSRENS 415 +E ++I G + Y+ + A K S E+ L + ++ Sbjct: 18 NEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATC-DHP 76 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 ++V G+ H G L++ + C +D E + + V + +A+ L Sbjct: 77 YIVKLLGAYYHDGKLWIMIEFCPGGA---VDAIMLELDRGLTEPQIQVVCRQMLEALNFL 133 Query: 476 HLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK-------------------------- 509 H S H+DL+ N+L+ + LADF S K Sbjct: 134 H-SKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCE 192 Query: 510 -WAGDPQEVKRDLEDLGRLVLYVVKKGSISFED-------LKAQSNEEVVQLSPDE---E 558 P + K D+ LG + L + + + LK ++ L+P + E Sbjct: 193 TMKDTPYDYKADIWSLG-ITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVE 251 Query: 559 TKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWES 591 +D + R + LL HPF + S Sbjct: 252 FRDFLKIALDKNPETRPSAAQLLEHPFVSSITS 284 >4B8L-A nrPDB Length = 286 Score = 125 bits (315), Expect = 4e-29, Method: Composition-based stats. Identities = 45/270 (16%), Positives = 89/270 (32%), Gaps = 47/270 (17%) Query: 364 FIDEKYKIADTSEGGIYLGFYEKQE------VAVKTFC------EGSPRA-QREVSCLQS 410 F + + I G + Y +E +A+K EG +RE+ Sbjct: 12 FTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSH 71 Query: 411 SRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFK 470 R + +++ Y R +++ + + + +++ + + + Sbjct: 72 LR-HPNILRMYNYFHDRKRIYLMLEFAPRGE----LYKELQKHGRFDEQRSATFMEELAD 126 Query: 471 AVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS--------IKWAGDPQEV----- 517 A+ H H+D++P+N+L+ K +ADF S G + Sbjct: 127 ALHYCHE-RKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMI 185 Query: 518 -------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVV-----QLSP--DEETKDLI 563 K DL G ++ Y G F+ + + P + +KDLI Sbjct: 186 EGKTHDEKVDLWCAG-VLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDLI 244 Query: 564 HRLFHPGEHVRDCLSDLLGHPFFWTWESRY 593 +L R L ++ HP+ R Sbjct: 245 SKLLRYHPPQRLPLKGVMEHPWVKANSRRV 274 >2RFA-A nrPDB Length = 232 Score = 125 bits (315), Expect = 5e-29, Method: Composition-based stats. Identities = 54/223 (24%), Positives = 91/223 (40%), Gaps = 25/223 (11%) Query: 92 GATPFILAAIAGSVKLLKLFLS-KGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGAN 150 +P +LAA V+ L L +G +V++ G TA AA+Y ++A L + Sbjct: 3 WESPLLLAAKENDVQALSKLLKFEGCEVHQRGAMGETALHIAALYDNLEAAMVLMEAAPE 62 Query: 151 VNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNAC-----DNMGRNA 205 + T E E G TAL A +V +++ LL GA V+A + + Sbjct: 63 LVFEPMTSELYE-----GQTALHIAVINQNVNLVRALLAR-GASVSARATGSVFHYRPHN 116 Query: 206 LI----HALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLG----LVQR 257 LI H L + E I LL++HGAD+ + G T L + + + + + Sbjct: 117 LIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNL 176 Query: 258 LLEQEHIE-----INDTDSDGKTALLLAVELKLKKIAELLCKR 295 LL + + ++ G T LA + + L ++ Sbjct: 177 LLSYDGGDHLKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQK 219 Score = 115 bits (289), Expect = 5e-26, Method: Composition-based stats. Identities = 49/217 (22%), Positives = 95/217 (43%), Gaps = 16/217 (7%) Query: 60 WTPLHNAVQMSREDIVELLLR-HGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADV 118 +PL A + + + LL+ G + R G T +AA+ +++ + + ++ Sbjct: 4 ESPLLLAAKENDVQALSKLLKFEGCEVHQRGAMGETALHIAALYDNLEAAMVLMEAAPEL 63 Query: 119 -----NECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRK---TKEDQERLRKGGAT 170 + G TA A + V ++ L RGA+V+ R L G Sbjct: 64 VFEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEH 123 Query: 171 ALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGA 230 L AA G E++++L+ E GAD+ A D++G L +L + + + +LLL + Sbjct: 124 PLSFAACVGSEEIVRLLI-EHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDG 182 Query: 231 DVNVR------GERGKTPLILAVEKKHLGLVQRLLEQ 261 +++ +G TP LA + ++ + Q L+++ Sbjct: 183 GDHLKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQK 219 Score = 72.4 bits (176), Expect = 7e-13, Method: Composition-based stats. Identities = 35/160 (21%), Positives = 64/160 (40%), Gaps = 23/160 (14%) Query: 170 TALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHG 229 + L+ AA++ V+ L LL G +V+ MG AL A L D +L++ Sbjct: 5 SPLLLAAKENDVQALSKLLKFEGCEVHQRGAMGETALHIAAL----YDNLEAAMVLMEAA 60 Query: 230 ADV-----NVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDS------------- 271 ++ G+T L +AV +++ LV+ LL + ++ + Sbjct: 61 PELVFEPMTSELYEGQTALHIAVINQNVNLVRALLAR-GASVSARATGSVFHYRPHNLIY 119 Query: 272 DGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRN 311 G+ L A + ++I LL + GA D + + Sbjct: 120 YGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLH 159 Score = 67.0 bits (162), Expect = 3e-11, Method: Composition-based stats. Identities = 38/152 (25%), Positives = 58/152 (38%), Gaps = 32/152 (21%) Query: 23 VEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEG------------GWTPLHNAVQMS 70 E L AV N++V+LV+ LL GA+V+ + G PL A + Sbjct: 73 YEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVG 132 Query: 71 REDIVELLLRHGADPVLRKKNGATPFIL---------AAIAGSVKLLKLFLSKGADVN-- 119 E+IV LL+ HGAD + G T + A ++ LS + Sbjct: 133 SEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNL-----LLSYDGGDHLK 187 Query: 120 ----ECDFYGFTAFMEAAVYGKVKALKFLYKR 147 + G T F A V G + + L ++ Sbjct: 188 SLELVPNNQGLTPFKLAGVEGNIVMFQHLMQK 219 >2F57-A nrPDB Length = 317 Score = 125 bits (315), Expect = 5e-29, Method: Composition-based stats. Identities = 48/292 (16%), Positives = 108/292 (36%), Gaps = 50/292 (17%) Query: 338 PQSSHWGAALKDLHRIYRPMI------GKLKFFIDEKYKIADTSEGGIYLG--FYEKQEV 389 ++ ++ + + H +R + G + ++ KI + S G + + + ++V Sbjct: 14 RENLYFQSMSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQV 73 Query: 390 AVKTFCEGSPRAQREV----SCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACL 445 AVK + + +RE+ + + ++V Y S L+V + E + Sbjct: 74 AVKKM-DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDI 132 Query: 446 DVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFD 505 H + E++ A L S+ +A+ LH + G H+D++ +IL+ S L+DF Sbjct: 133 VTHTRMN----EEQIATVCL-SVLRALSYLH-NQGVIHRDIKSDSILLTSDGRIKLSDFG 186 Query: 506 KSIKWAGD----------------------PQEVKRDLEDLGRLVLYVVKK-----GSIS 538 + + + P + D+ LG +V+ ++ Sbjct: 187 FCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPP 246 Query: 539 FEDLKAQSNEEVVQLSP----DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + ++ + ++ + + + R +LLGHPF Sbjct: 247 LQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFL 298 >3KN6-A nrPDB Length = 325 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 45/245 (18%), Positives = 83/245 (33%), Gaps = 50/245 (20%) Query: 386 KQEVAVKTFCEGSP-RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEAC 444 Q AVK + Q+E++ L+ + ++V + + H F+ + L L Sbjct: 36 NQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMEL----LNGG 91 Query: 445 LDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILI---DSKKAAHL 501 R + ++ + A ++ + AV +H G H+DL+P+N+L + + Sbjct: 92 ELFERIKKKKHFSETEASYIMRKLVSAVSHMH-DVGVVHRDLKPENLLFTDENDNLEIKI 150 Query: 502 ADFDKS----------IKWAGDPQEV------------KRDLEDLGRLVLYVVKKGSISF 539 DF + DL LG ++LY + G + F Sbjct: 151 IDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLG-VILYTMLSGQVPF 209 Query: 540 EDLKAQ------------------SNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLL 581 + S E + +E KDLI L + R +S L Sbjct: 210 QSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLR 269 Query: 582 GHPFF 586 + + Sbjct: 270 YNEWL 274 >5N23-A nrPDB Length = 352 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 70/380 (18%), Positives = 124/380 (32%), Gaps = 68/380 (17%) Query: 305 VMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFF 364 A++ + VK L AKEDF E ++H L RI G Sbjct: 4 AAAAKKGSEQESVKEFL-AKAKEDFLKKWESPAQNTAH----LDQFERIRTLGTGSFGRV 58 Query: 365 IDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSE 424 + + G Y ++ VK + E +Q + LV S Sbjct: 59 M----LVKHKETGNHYAMKILDKQKVVK--LKQIEHTLNE-KRIQQAVNFPFLVKLEFSF 111 Query: 425 SHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQ 484 +L++ + + + AR + I + LH S ++ Sbjct: 112 KDNSNLYMVLEYAPGGEM----FSHLRRIGRFSEPHARFYAAQIVLTFEYLH-SLDLIYR 166 Query: 485 DLQPQNILIDSKKAAHLADFDKSIK--------WAGDPQEV------------KRDLEDL 524 DL+P+N+LID + +ADF + + G P+ + D L Sbjct: 167 DLKPENLLIDQQGYIKVADFGFAKRVKGRTPWTLCGTPEYLAPEIILSKGYNKAVDWWAL 226 Query: 525 GRLVLYVVKKGSISFEDLKAQSNEEVV-------QLSPDEETKDLIHRLFHPGEHVR--- 574 G +++Y + G F + E + + KDL+ L R Sbjct: 227 G-VLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGN 285 Query: 575 --DCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKW 632 + ++D+ H +F T + I RK E+ + + + +FD + Sbjct: 286 LKNGVNDIKNHKWFAT-----------TDWIAIYQRKVEAPFIPKFKGPGD--TSNFDDY 332 Query: 633 -----TTKINECVMKKMNKF 647 INE K+ ++F Sbjct: 333 EEEEIRVSINEKCGKEFSEF 352 >2X4F-A nrPDB Length = 373 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 46/285 (16%), Positives = 104/285 (36%), Gaps = 54/285 (18%) Query: 351 HRIYRPMIGKLKFFIDEKYKI--ADTSEGGIYLGFYEKQE------VAVKTFCEGSPRAQ 402 HRI G + F Y + + GG + ++ +E +A K + + Sbjct: 75 HRIVTAKQGAVNSF----YTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDK 130 Query: 403 REVS---CLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDE 459 EV + + ++++L+ Y + + + + + + + ++ + Sbjct: 131 EEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLT---EL 187 Query: 460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNIL-IDSK-KAAHLADFDKSIKWA------ 511 + I + ++ +H H DL+P+NIL ++ K + DF + ++ Sbjct: 188 DTILFMKQICEGIRHMHQ-MYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLK 246 Query: 512 ---GDPQEVK------------RDLEDLGRLVLYVVKKGSISF-EDLKAQSNEEVVQL-- 553 G P+ + D+ +G ++ Y++ G F D A++ ++ Sbjct: 247 VNFGTPEFLAPEVVNYDFVSFPTDMWSVG-VIAYMLLSGLSPFLGDNDAETLNNILACRW 305 Query: 554 --------SPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWE 590 EE K+ I +L + R S+ L HP+ + Sbjct: 306 DLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSDHK 350 >2KXP-C nrPDB Length = 118 Score = 124 bits (310), Expect = 2e-28, Method: Composition-based stats. Identities = 44/112 (39%), Positives = 59/112 (52%), Gaps = 2/112 (1%) Query: 30 IKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRK 89 + A++N D+D V+ + G +VN + EGG PLH A + +I+E LL GAD Sbjct: 7 MWALKNGDLDEVKDYVAKGEDVN-RTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPD 65 Query: 90 KNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKAL 141 K+ TP + A G V +KL LSKGAD G TA EA +KAL Sbjct: 66 KHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAL-EATDNQAIKAL 116 Score = 85.1 bits (209), Expect = 9e-17, Method: Composition-based stats. Identities = 27/107 (25%), Positives = 44/107 (41%) Query: 63 LHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECD 122 A++ D V+ + G D + G P AA G +++L+ L KGAD+N D Sbjct: 6 FMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPD 65 Query: 123 FYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGA 169 + T + A G V +K L +GA+ ++ A Sbjct: 66 KHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTALEATDNQA 112 Score = 70.1 bits (170), Expect = 4e-12, Method: Composition-based stats. Identities = 34/105 (32%), Positives = 49/105 (46%), Gaps = 6/105 (5%) Query: 173 MDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADV 232 M A + G ++ +K + + G DVN GR L +A D I LL GAD+ Sbjct: 7 MWALKNGDLDEVKDYVAK-GEDVNRTLEGGRKPLHYAA----DCGQLEILEFLLLKGADI 61 Query: 233 NVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTAL 277 N + TPL+ AV + H+ V+ LL + + DG TAL Sbjct: 62 NAPDKHHITPLLSAVYEGHVSCVKLLLSK-GADKTVKGPDGLTAL 105 Score = 66.6 bits (161), Expect = 4e-11, Method: Composition-based stats. Identities = 38/116 (32%), Positives = 53/116 (45%), Gaps = 15/116 (12%) Query: 129 FMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188 FM A G + +K +G +VN R +GG L AA+ G +E+L+ LL Sbjct: 6 FMWALKNGDLDEVKDYVAKGEDVN----------RTLEGGRKPLHYAADCGQLEILEFLL 55 Query: 189 DEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLI 244 + GAD+NA D L+ A+ + LLL GAD V+G G T L Sbjct: 56 LK-GADINAPDKHHITPLLSAVYEGH----VSCVKLLLSKGADKTVKGPDGLTALE 106 Score = 55.9 bits (133), Expect = 7e-08, Method: Composition-based stats. Identities = 25/86 (29%), Positives = 41/86 (47%), Gaps = 5/86 (5%) Query: 28 LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVL 87 L A +++++ LL GA++N ++ TPL +AV V+LLL GAD + Sbjct: 38 PLHYAADCGQLEILEFLLLKGADINAPDKH-HITPLLSAVYEGHVSCVKLLLSKGADKTV 96 Query: 88 RKKNGATPFILAAIAGSVKLLKLFLS 113 + +G T A A + +K L Sbjct: 97 KGPDGLT----ALEATDNQAIKALLQ 118 Score = 50.5 bits (119), Expect = 3e-06, Method: Composition-based stats. Identities = 24/93 (25%), Positives = 40/93 (43%), Gaps = 6/93 (6%) Query: 245 LAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDL 304 A++ L V+ + + ++N T G+ L A + +I E L +GA + D Sbjct: 8 WALKNGDLDEVKDYVAK-GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDK 66 Query: 305 V-----MTARRNYDHSLVKVLLSHGAKEDFHPP 332 ++A S VK+LLS GA + P Sbjct: 67 HHITPLLSAVYEGHVSCVKLLLSKGADKTVKGP 99 >2VD5-A nrPDB Length = 412 Score = 124 bits (310), Expect = 2e-28, Method: Composition-based stats. Identities = 62/289 (21%), Positives = 97/289 (33%), Gaps = 63/289 (21%) Query: 356 PMIGKLKF--FIDEKYKIADTSEGGIYLGF------YEKQEVAVKTFCEGSPRAQREVSC 407 P++ +LK + ++I G + Q A+K + + EVSC Sbjct: 48 PIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSC 107 Query: 408 LQSSRE------NSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFA 461 + R+ + + + +L++ + L GE + E A Sbjct: 108 FREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAE---MA 164 Query: 462 RNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWA---------- 511 R L+ I A+ +H GY H+D++P NIL+D LADF +K Sbjct: 165 RFYLAEIVMAIDSVHR-LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVA 223 Query: 512 -GDPQEV-------------------KRDLEDLGRLVLYVVKKGSISFEDL--------- 542 G P + + D LG + Y + G F Sbjct: 224 VGTPDYLSPEILQAVGGGPGTGSYGPECDWWALG-VFAYEMFYGQTPFYADSTAETYGKI 282 Query: 543 ---KAQSNEEVVQLSPDEETKDLIHRLFHPGEHV--RDCLSDLLGHPFF 586 K + +V EE +D I RL P E R D HPFF Sbjct: 283 VHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFF 331 >4AF3-A nrPDB Length = 292 Score = 124 bits (310), Expect = 2e-28, Method: Composition-based stats. Identities = 46/272 (16%), Positives = 94/272 (34%), Gaps = 47/272 (17%) Query: 362 KFFIDEKYKIADTSEGGIYLGFYEKQE------VAVKTFC------EGSPRA-QREVSCL 408 + F + ++I G + Y +E VA+K EG +RE+ + Sbjct: 18 RHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIE-I 76 Query: 409 QSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 Q+ + +++ Y R +++ + + + +++ ++ + Sbjct: 77 QAHLHHPNILRLYNYFYDRRRIYLILEYAPRGE----LYKELQKSCTFDEQRTATIMEEL 132 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS--------IKWAGDPQEV--- 517 A+ H H+D++P+N+L+ K +ADF S G + Sbjct: 133 ADALMYCHGK-KVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPE 191 Query: 518 ---------KRDLEDLGRLVLYVVKKGSISFEDL-------KAQSNEEVVQLSPDEETKD 561 K DL +G ++ Y + G+ FE + + S +D Sbjct: 192 MIEGRMHNEKVDLWCIG-VLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQD 250 Query: 562 LIHRLFHPGEHVRDCLSDLLGHPFFWTWESRY 593 LI +L R L+ + HP+ R Sbjct: 251 LISKLLRHNPSERLPLAQVSAHPWVRANSRRV 282 >4JDH-A nrPDB Length = 346 Score = 123 bits (309), Expect = 2e-28, Method: Composition-based stats. Identities = 56/294 (19%), Positives = 107/294 (36%), Gaps = 46/294 (15%) Query: 330 HPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEK--Q 387 P + +PQ L + P G + ++D KI + S G + + + Sbjct: 43 GPRSPQREPQRVSHEQFRAALQLVVDP--GDPRSYLDNFIKIGEGSTGIVCIATVRSSGK 100 Query: 388 EVAVKTFCEGSPRAQREV----SCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEA 443 VAVK + + +RE+ + ++ ++V Y S L+V + E Sbjct: 101 LVAVKKM-DLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALT 159 Query: 444 CLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLAD 503 + H + E++ A L+ + +A+ LH + G H+D++ +IL+ L+D Sbjct: 160 DIVTHTRMN----EEQIAAVCLA-VLQALSVLH-AQGVIHRDIKSDSILLTHDGRVKLSD 213 Query: 504 FDKSIKWA----------GDPQEV------------KRDLEDLGRLVLYVVKK-----GS 536 F + + G P + + D+ LG +V+ +V Sbjct: 214 FGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNE 273 Query: 537 ISFEDLKAQSNEEVVQLSP----DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + +K + +L K + RL R ++LL HPF Sbjct: 274 PPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 327 >2WQN-A nrPDB Length = 310 Score = 123 bits (309), Expect = 3e-28, Method: Composition-based stats. Identities = 52/295 (17%), Positives = 95/295 (32%), Gaps = 60/295 (20%) Query: 330 HPPAEDWKPQSSHWGAALKDLHRIYRPMIG--KLKFFIDEKYKIADTSEGGIYLG--FYE 385 PP ++PQ + RP +G L F EK KI +Y + Sbjct: 10 GPPVPQFQPQKA------------LRPDMGYNTLANFRIEK-KIGRGQFSEVYRAACLLD 56 Query: 386 KQEVAVKTF-----CEGSPRAQ--REVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCE 438 VA+K + RA +E+ L+ + +++ +Y S L + + L + Sbjct: 57 GVPVALKKVQIFDLMDAKARADCIKEIDLLKQL-NHPNVIKYYASFIEDNELNIVLELAD 115 Query: 439 QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA 498 + + H + + + A++ +H S H+D++P N+ I + Sbjct: 116 AGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMH-SRRVMHRDIKPANVFITATGV 174 Query: 499 AHLADFDK----------SIKWAGDPQE------------VKRDLEDLGRLVLYVVKKGS 536 L D + G P K D+ LG L LY + Sbjct: 175 VKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCL-LYEMAALQ 233 Query: 537 ISFEDLK-----------AQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDL 580 F K + EE + L++ +P R ++ + Sbjct: 234 SPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYV 288 >3HKO-A nrPDB Length = 345 Score = 123 bits (309), Expect = 3e-28, Method: Composition-based stats. Identities = 52/312 (16%), Positives = 103/312 (33%), Gaps = 93/312 (29%) Query: 371 IADTSEGGIYLGFYEKQEVAVKTF------------CEGSPRAQREVSCLQSSRENSHLV 418 I S G + + E Q A++ + R + EV ++ + ++ Sbjct: 34 IGQGSYGVVRVAI-ENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLH-HPNIA 91 Query: 419 TFYGSESHRGHLFVCVTLCEQ--------------TLEACLDVHRGEDVENEE------- 457 Y ++ + + LC T + +DV + + E Sbjct: 92 RLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNEEAIN 151 Query: 458 ---------------DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKK--AAH 500 ++ N++ IF A+ LH + G H+D++P+N L + K Sbjct: 152 GSIHGFRESLDFVQREKLISNIMRQIFSALHYLH-NQGICHRDIKPENFLFSTNKSFEIK 210 Query: 501 LADFDKSIKW--------------AGDPQEV--------------KRDLEDLGRLVLYVV 532 L DF S ++ AG P V K D G ++L+++ Sbjct: 211 LVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAG-VLLHLL 269 Query: 533 KKGSISF------EDLKAQSNEEVVQLSP-----DEETKDLIHRLFHPGEHVRDCLSDLL 581 G++ F + + N+++ +P +DL+ L + R L Sbjct: 270 LMGAVPFPGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDAMRAL 329 Query: 582 GHPFFWTWESRY 593 HP+ + + Sbjct: 330 QHPWISQFSDKI 341 >3ORZ-A nrPDB Length = 316 Score = 123 bits (309), Expect = 3e-28, Method: Composition-based stats. Identities = 50/272 (18%), Positives = 86/272 (31%), Gaps = 57/272 (20%) Query: 367 EKYKIADTSEGGIYLGFYEKQEVA------VKTFC-------EGSPRAQREVSCLQSSRE 413 E +K G + +E+A +K P RE + + Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-D 95 Query: 414 NSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQ 473 + V Y L+ ++ + L R + + ++ R + I A++ Sbjct: 96 HPFFVKLYFCFQDDEKLYFGLSYAKNG--ELLKYIR--KIGSFDETCTRFYTAEIVSALE 151 Query: 474 ELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWA------------GDPQEV---- 517 LH G H+DL+P+NIL++ + DF + + G Q V Sbjct: 152 YLHGK-GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPEL 210 Query: 518 --------KRDLEDLGRLVLYVVKKGSISFED-------LKAQSNEEVVQLSPDEETKDL 562 DL LG ++ Y + G F K E + +DL Sbjct: 211 LTEKSACKSSDLWALGCII-YQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDL 269 Query: 563 IHRLFHPGEHVRDCLSD------LLGHPFFWT 588 + +L R + L HPFF + Sbjct: 270 VEKLLVLDATKRLGCEEMEGYGPLKAHPFFES 301 >4FIE-A nrPDB Length = 423 Score = 123 bits (308), Expect = 3e-28, Method: Composition-based stats. Identities = 56/294 (19%), Positives = 107/294 (36%), Gaps = 46/294 (15%) Query: 330 HPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEK--Q 387 P + +PQ L + P G + ++D KI + S G + + + Sbjct: 120 GPRSPQREPQRVSHEQFRAALQLVVDP--GDPRSYLDNFIKIGEGSTGIVCIATVRSSGK 177 Query: 388 EVAVKTFCEGSPRAQREV----SCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEA 443 VAVK + + +RE+ + ++ ++V Y S L+V + E Sbjct: 178 LVAVKKM-DLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALT 236 Query: 444 CLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLAD 503 + H + E++ A L+ + +A+ LH + G H+D++ +IL+ L+D Sbjct: 237 DIVTHTRMN----EEQIAAVCLA-VLQALSVLH-AQGVIHRDIKSDSILLTHDGRVKLSD 290 Query: 504 FDKSIKWA----------GDPQEV------------KRDLEDLGRLVLYVVKK-----GS 536 F + + G P + + D+ LG +V+ +V Sbjct: 291 FGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNE 350 Query: 537 ISFEDLKAQSNEEVVQLSP----DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + +K + +L K + RL R ++LL HPF Sbjct: 351 PPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 404 >6BOA-A nrPDB Length = 742 Score = 122 bits (307), Expect = 4e-28, Method: Composition-based stats. Identities = 52/228 (22%), Positives = 88/228 (38%), Gaps = 26/228 (11%) Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKG-ADVNECDFYGFTAFMEAAVYGKVKALKFLYK 146 +K+ +P +LAA V+ L L V++ G TA AA+Y ++A L + Sbjct: 41 QKRIWESPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLME 100 Query: 147 RGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNAC---DNMGR 203 + T E E G TAL A ++ +++ LL A V+A R Sbjct: 101 AAPELVFEPMTSELYE-----GQTALHIAVVNQNMNLVRALLAR-RASVSARATGTAFRR 154 Query: 204 NAL------IHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLG---- 253 + H L + + E I LL++HGAD+ + G T L + + + + Sbjct: 155 SPCNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQ 214 Query: 254 LVQRLLE--QEHIEINDTD----SDGKTALLLAVELKLKKIAELLCKR 295 + LL + + D G T LA + + L ++ Sbjct: 215 MYNLLLSYDRHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 Score = 103 bits (256), Expect = 3e-22, Method: Composition-based stats. Identities = 56/257 (21%), Positives = 104/257 (40%), Gaps = 30/257 (11%) Query: 60 WTPLHNAVQMSREDIVELLLRH-GADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADV 118 +PL A + + + LL++ R G T +AA+ +++ + + ++ Sbjct: 46 ESPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPEL 105 Query: 119 -----NECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRK---TKEDQERLRKGGAT 170 + G TA A V + ++ L R A+V+ R + L G Sbjct: 106 VFEPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEH 165 Query: 171 ALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLD--- 227 L AA E++++L+ E GAD+ A D++G L +L + + + +LLL Sbjct: 166 PLSFAACVNSEEIVRLLI-EHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDR 224 Query: 228 HGADVN----VRGERGKTPLILAVEKKHLGLVQRLLEQEH-------------IEINDTD 270 HG + V +G TP LA + + + Q L+++ ++ + D Sbjct: 225 HGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTLYDLTEID 284 Query: 271 SDGKTALLLAVELKLKK 287 S G LL + + KK Sbjct: 285 SSGDEQSLLELIITTKK 301 Score = 72.4 bits (176), Expect = 7e-13, Method: Composition-based stats. Identities = 54/331 (16%), Positives = 108/331 (32%), Gaps = 60/331 (18%) Query: 153 LRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLS 212 + + +++ + ++ + L+ AA+ V+ L LL V+ MG AL A L Sbjct: 30 AQSRDEQNLLQQKRIWESPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAAL- 88 Query: 213 SDDSDVEAITHLLLDHGADV-----NVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEIN 267 D +L++ ++ G+T L +AV +++ LV+ LL + ++ Sbjct: 89 ---YDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVVNQNMNLVRALLARR-ASVS 144 Query: 268 DTDS-------------DGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRN--- 311 + G+ L A + ++I LL + GA D + + Sbjct: 145 ARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILI 204 Query: 312 ------YDHSLVKVLLSHGAKEDFHPPAEDWKPQS------------------SHWGAAL 347 + + +LLS+ D H D P H Sbjct: 205 LQPNKTFACQMYNLLLSYDRHGD-HLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKR 263 Query: 348 KDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSC 407 K Y P+ L + + E + ++ + + +P + VS Sbjct: 264 KHTQWTYGPLTSTLYDLTEID---SSGDEQSLLELIITTKKREARQILDQTP-VKELVSL 319 Query: 408 LQSSRENSHLVTFYGSESHRGHLF-VCVTLC 437 ++ L+ +C T+C Sbjct: 320 KWKRYGRP----YFCMLGAIYLLYIICFTMC 346 Score = 62.8 bits (151), Expect = 5e-10, Method: Composition-based stats. Identities = 38/153 (24%), Positives = 58/153 (37%), Gaps = 33/153 (21%) Query: 23 VEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEG------------GWTPLHNAVQMS 70 E L AV N++++LV+ LL A+V+ + G PL A ++ Sbjct: 115 YEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVN 174 Query: 71 REDIVELLLRHGADPVLRKKNGATPFIL---------AAIAGSVKLLKLFLS---KGADV 118 E+IV LL+ HGAD + G T + A ++ LS G + Sbjct: 175 SEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNL-----LLSYDRHGDHL 229 Query: 119 NECDF----YGFTAFMEAAVYGKVKALKFLYKR 147 D G T F A V G + L ++ Sbjct: 230 QPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 >2WTK-C nrPDB Length = 305 Score = 122 bits (306), Expect = 5e-28, Method: Composition-based stats. Identities = 42/327 (12%), Positives = 95/327 (29%), Gaps = 78/327 (23%) Query: 368 KYKIADTSEGGIY---LGFYEKQEVAVKTF-----------CEGSPRAQREVSCLQSSRE 413 KY + D G Y + + + + G ++E+ L+ R Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLR- 64 Query: 414 NSHLVTFYGSE--SHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 471 + +++ + +++ + C ++ LD + + A + Sbjct: 65 HKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQ---AHGYFCQLIDG 121 Query: 472 VQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDK------------SIKWAGDP----- 514 ++ LH S G H+D++P N+L+ + ++ G P Sbjct: 122 LEYLH-SQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPP 180 Query: 515 ---------QEVKRDLEDLGRLVLYVVKKGSISFEDL-------KAQSNEEVVQLSPDEE 558 K D+ G + LY + G FE + Sbjct: 181 EIANGLDTFSGFKVDIWSAG-VTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPP 239 Query: 559 TKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLL 618 DL+ + R + + H +F + + +E + Sbjct: 240 LSDLLKGMLEYEPAKRFSIRQIRQHSWF-------------------RKKHPPAEAPVPI 280 Query: 619 QPGPSEHSKSFDKWTTKINECVMKKMN 645 P P + D+W + ++ ++ Sbjct: 281 PPSPD----TKDRWRSMTVVPYLEDLH 303 >1U5R-A nrPDB Length = 348 Score = 122 bits (306), Expect = 6e-28, Method: Composition-based stats. Identities = 54/310 (17%), Positives = 102/310 (32%), Gaps = 53/310 (17%) Query: 356 PMIGKLKFFIDEKY------KIADTSEGGIY--LGFYEKQEVAVKTFC-------EGSPR 400 P + +L F D + +I S G +Y + VA+K E Sbjct: 41 PDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQD 100 Query: 401 AQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEF 460 +EV LQ R + + + + G ++ + C + L+VH+ +E E Sbjct: 101 IIKEVRFLQKLR-HPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK---KPLQEVEI 156 Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI------KWAGDP 514 A V + + LH S H+D++ NIL+ L DF + + G P Sbjct: 157 A-AVTHGALQGLAYLH-SHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTP 214 Query: 515 QEV---------------KRDLEDLGRLVLYVVKKGSISFEDLKAQS---------NEEV 550 + K D+ LG + + + ++ A S + + Sbjct: 215 YWMAPEVILAMDEGQYDGKVDVWSLGITCI-ELAERKPPLFNMNAMSALYHIAQNESPAL 273 Query: 551 VQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKS 610 E ++ + R LL H F E + ++ + R+ Sbjct: 274 QSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFV-LRERPPTVIMDLIQRTKDAVREL 332 Query: 611 ESEILRLLQP 620 ++ R ++ Sbjct: 333 DNLQYRKMKK 342 >3DAK-A nrPDB Length = 290 Score = 122 bits (306), Expect = 6e-28, Method: Composition-based stats. Identities = 46/280 (16%), Positives = 93/280 (33%), Gaps = 63/280 (22%) Query: 367 EKYKIADTSEGGIYLGFY------EKQEVAVKTF-CEGSPRA----QREVSCLQSSRENS 415 + Y++ + G +K++VA+K E + +E+ + + Sbjct: 10 DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCH-HP 68 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVH---RGEDVENEEDEFAR-NVLSSIFKA 471 ++V++Y S + L++ + L + H +GE DE +L + + Sbjct: 69 NIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEG 128 Query: 472 VQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS---------------IKWAGDP-- 514 ++ LH + G H+D++ NIL+ + +ADF S + G P Sbjct: 129 LEYLHKN-GQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCW 187 Query: 515 -----------QEVKRDLEDLGRLVLYVVKKG------SISFEDLKAQSNEEVVQLSP-- 555 + K D+ G + + G + L + L Sbjct: 188 MAPEVMEQVRGYDFKADIWSFGITAI-ELATGAAPYHKYPPMKVLMLTLQNDPPSLETGV 246 Query: 556 ---------DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + + +I R ++LL H FF Sbjct: 247 QDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF 286 >4L42-A nrPDB Length = 346 Score = 122 bits (306), Expect = 6e-28, Method: Composition-based stats. Identities = 46/251 (18%), Positives = 93/251 (37%), Gaps = 42/251 (16%) Query: 370 KIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGH 429 K+ + G I+ K+ + V+ + + + E + L+ ++ +V + G Sbjct: 39 KVTGANTGKIFAMKVLKKAMIVRNAKDTA-HTKAERNILEEV-KHPFIVDLIYAFQTGGK 96 Query: 430 LFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQ 489 L++ + L + E ++ A L+ I A+ LH G ++DL+P+ Sbjct: 97 LYLILEY----LSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQK-GIIYRDLKPE 151 Query: 490 NILIDSKKAAHLADFDKSIK----------WAGDPQEV------------KRDLEDLGRL 527 NI+++ + L DF + + G + + D LG L Sbjct: 152 NIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGAL 211 Query: 528 VLYVVKKGSISFEDLKAQSNEEVV-----QLSPD--EETKDLIHRLFHPGEHVRD----- 575 + Y + G+ F + + + L P +E +DL+ +L R Sbjct: 212 M-YDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPG 270 Query: 576 CLSDLLGHPFF 586 ++ HPFF Sbjct: 271 DAGEVQAHPFF 281 >2Q0N-A nrPDB Length = 301 Score = 122 bits (305), Expect = 7e-28, Method: Composition-based stats. Identities = 55/287 (19%), Positives = 105/287 (36%), Gaps = 46/287 (16%) Query: 337 KPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEK--QEVAVKTF 394 +PQ L + P G + ++D KI + S G + + + VAVK Sbjct: 5 EPQRVSHEQFRAALQLVVDP--GDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM 62 Query: 395 CEGSPRAQREV----SCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRG 450 + + +RE+ + ++ ++V Y S L+V + E + H Sbjct: 63 -DLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR 121 Query: 451 EDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKW 510 + E++ A L+ + +A+ LH + G H+D++ +IL+ L+DF + Sbjct: 122 MN----EEQIAAVCLA-VLQALSVLH-AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV 175 Query: 511 A----------GDPQEV------------KRDLEDLGRLVLYVVKK-----GSISFEDLK 543 + G P + + D+ LG +V+ +V + +K Sbjct: 176 SKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMK 235 Query: 544 AQSNEEVVQLSP----DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + +L K + RL R ++LL HPF Sbjct: 236 MIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 282 >4RLP-A nrPDB Length = 288 Score = 122 bits (305), Expect = 7e-28, Method: Composition-based stats. Identities = 46/251 (18%), Positives = 93/251 (37%), Gaps = 42/251 (16%) Query: 370 KIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGH 429 K+ + G I+ K+ + V+ + + + E + L+ ++ +V + G Sbjct: 26 KVTGANTGKIFAMKVLKKAMIVRNAKDTA-HTKAERNILEEV-KHPFIVDLIYAFQTGGK 83 Query: 430 LFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQ 489 L++ + L + E ++ A L+ I A+ LH G ++DL+P+ Sbjct: 84 LYLILEY----LSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQK-GIIYRDLKPE 138 Query: 490 NILIDSKKAAHLADFDKSIK----------WAGDPQEV------------KRDLEDLGRL 527 NI+++ + L DF + + G + + D LG L Sbjct: 139 NIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGAL 198 Query: 528 VLYVVKKGSISFEDLKAQSNEEVV-----QLSPD--EETKDLIHRLFHPGEHVRD----- 575 + Y + G+ F + + + L P +E +DL+ +L R Sbjct: 199 M-YDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPG 257 Query: 576 CLSDLLGHPFF 586 ++ HPFF Sbjct: 258 DAGEVQAHPFF 268 >4IC8-A nrPDB Length = 442 Score = 122 bits (305), Expect = 8e-28, Method: Composition-based stats. Identities = 55/361 (15%), Positives = 113/361 (31%), Gaps = 90/361 (24%) Query: 315 SLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLH-RIYRPMIGKLKFFIDEKYKIAD 373 S+ + L ++ P K + +H A++ + + + + F + ++Y+I + Sbjct: 2 SMAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIE 61 Query: 374 TSEGGIY------LGFYEKQEVAVKTFCEG------SPRAQREVSCLQSSRENSHLVTFY 421 T G Y Q+VA+K + R RE+ L+ ++ +++ Sbjct: 62 TIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHF-KHDNIIAIK 120 Query: 422 GSESHR------GHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 ++V + L E L +H + + E R L + + ++ + Sbjct: 121 DILRPTVPYGEFKSVYVVLDLMESDL--HQIIHSSQPLTLE---HVRYFLYQLLRGLKYM 175 Query: 476 HLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDP--------------------- 514 H S H+DL+P N+L++ + DF + P Sbjct: 176 H-SAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPEL 234 Query: 515 ------QEVKRDLEDLGRLV--------------------LYVVKKGSIS---------- 538 DL +G + L ++ G+ S Sbjct: 235 MLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAE 294 Query: 539 -----FEDLKAQSNEEVVQLSP--DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWES 591 + L + + P D + L+ R+ R + L HPF + Sbjct: 295 RVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHD 354 Query: 592 R 592 Sbjct: 355 P 355 >4C0T-A nrPDB Length = 974 Score = 122 bits (305), Expect = 8e-28, Method: Composition-based stats. Identities = 53/311 (17%), Positives = 102/311 (32%), Gaps = 60/311 (19%) Query: 331 PPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDE--KYKIADTSEGGIYLGFYEKQE 388 P +E K +W + I + M G++K +K G Y + Sbjct: 229 PKSETLKQNEENWEKKGAAVKTI-KTMDGEMKTIRRNVTDFKFGKELGEGSYSTVILATD 287 Query: 389 V------AVKTFCE-------GSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVT 435 AVK + E L +++ Y + + L+ + Sbjct: 288 KITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRLGVISLYFTFQDKDSLYFVLD 347 Query: 436 LCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDS 495 L + + + NEE R+ + I A++ +H + G H+DL+P+NIL+D Sbjct: 348 YASNG--ELLTLIKRYNTLNEE--CTRHFGAQILDAIKYMHDN-GVIHRDLKPENILLDD 402 Query: 496 KKAAHLADFD-------------------KSIKWAGDPQEVK------------RDLEDL 524 K + DF ++ + G + V D+ Sbjct: 403 KMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPELLENKYCGKPGDVWAF 462 Query: 525 GRLVLYVVKKGSISFEDLKAQSNEEVV---QLSPDE----ETKDLIHRLFHPGEHVRDCL 577 G ++ Y + G F+ + + Q + +DLI ++ R + Sbjct: 463 GCII-YQMIAGKPPFKATNEYLTFQKITKLQFAFSAGFPTIIRDLIKKILVLQPSRRATI 521 Query: 578 SDLLGHPFFWT 588 ++ H FF + Sbjct: 522 PEIQKHYFFQS 532 >4WB7-A nrPDB Length = 405 Score = 121 bits (304), Expect = 1e-27, Method: Composition-based stats. Identities = 68/372 (18%), Positives = 120/372 (32%), Gaps = 68/372 (18%) Query: 312 YDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKI 371 Y + + L AKEDF E ++H L RI G + + Sbjct: 66 YGEEVKEFLAK--AKEDFLKKWESPAQNTAH----LDQFERIKTLGTGSFGRVM----LV 115 Query: 372 ADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLF 431 G Y ++ VK + E LQ+ LV S +L+ Sbjct: 116 KHKETGNHYAMKILDKQKVVK--LKQIEHTLNEKRILQAV-NFPFLVKLEFSFKDNSNLY 172 Query: 432 VCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNI 491 + + + + AR + I + LH S ++DL+P+N+ Sbjct: 173 MVMEYVPGGEM----FSHLRRIGRFSEPHARFYAAQIVLTFEYLH-SLDLIYRDLKPENL 227 Query: 492 LIDSKKAAHLADFDKSIK-------WAGDPQEV------------KRDLEDLGRLVLYVV 532 LID + + DF + + G P+ + D LG +++Y + Sbjct: 228 LIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALG-VLIYEM 286 Query: 533 KKGSISFEDLKAQSNEEVV-------QLSPDEETKDLIHRLFHPGEHVR-----DCLSDL 580 G F + E + + KDL+ L R + ++D+ Sbjct: 287 AAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDI 346 Query: 581 LGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKW-----TTK 635 H +F T + I RK E+ + + + +FD + Sbjct: 347 KNHKWFAT-----------TDWIAIYQRKVEAPFIPKFKGPGD--TSNFDDYEEEEIRVS 393 Query: 636 INECVMKKMNKF 647 INE K+ ++F Sbjct: 394 INEKCGKEFSEF 405 >3EQC-A nrPDB Length = 360 Score = 121 bits (304), Expect = 1e-27, Method: Composition-based stats. Identities = 55/308 (17%), Positives = 98/308 (31%), Gaps = 85/308 (27%) Query: 358 IGKLKFFIDEKY-KIADTSEGGIYLGFYEKQE--VAVKTF-CEGSPRAQ----REVSCLQ 409 +G+LK EK ++ + G ++ ++ +A K E P + RE+ L Sbjct: 27 VGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLH 86 Query: 410 SSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIF 469 + ++V FYG+ G + +C+ + LD + E + ++ + Sbjct: 87 EC-NSPYIVGFYGAFYSDGEISICMEHMDGGS---LDQVLKKAGRIPEQILGKVSIA-VI 141 Query: 470 KAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS--------------------IK 509 K + L H+D++P NIL++S+ L DF S + Sbjct: 142 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPER 201 Query: 510 WAGDPQEVKRDLEDLGRLVLYVVKKGSIS------------------------------- 538 G V+ D+ +G L L + G Sbjct: 202 LQGTHYSVQSDIWSMG-LSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTP 260 Query: 539 -----------------FEDLKAQSNEEVVQLSP---DEETKDLIHRLFHPGEHVRDCLS 578 FE L NE +L E +D +++ R L Sbjct: 261 GRPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLK 320 Query: 579 DLLGHPFF 586 L+ H F Sbjct: 321 QLMVHAFI 328 >2GCD-A nrPDB Length = 309 Score = 121 bits (304), Expect = 1e-27, Method: Composition-based stats. Identities = 54/310 (17%), Positives = 102/310 (32%), Gaps = 53/310 (17%) Query: 356 PMIGKLKFFIDEKY------KIADTSEGGIY--LGFYEKQEVAVKTFC-------EGSPR 400 P + +L F D + +I S G +Y + VA+K E Sbjct: 2 PDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQD 61 Query: 401 AQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEF 460 +EV LQ R + + + + G ++ + C + L+VH+ +E E Sbjct: 62 IIKEVRFLQKLR-HPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK---KPLQEVEI 117 Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI------KWAGDP 514 A V + + LH S H+D++ NIL+ L DF + + G P Sbjct: 118 A-AVTHGALQGLAYLH-SHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTP 175 Query: 515 QEV---------------KRDLEDLGRLVLYVVKKGSISFEDLKAQS---------NEEV 550 + K D+ LG + + + ++ A S + + Sbjct: 176 YWMAPEVILAMDEGQYDGKVDVWSLGITCI-ELAERKPPLFNMNAMSALYHIAQNESPAL 234 Query: 551 VQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKS 610 E ++ + R LL H F E + ++ + R+ Sbjct: 235 QSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFV-LRERPPTVIMDLIQRTKDAVREL 293 Query: 611 ESEILRLLQP 620 ++ R ++ Sbjct: 294 DNLQYRKMKK 303 >2UV2-A nrPDB Length = 325 Score = 121 bits (304), Expect = 1e-27, Method: Composition-based stats. Identities = 49/266 (18%), Positives = 85/266 (31%), Gaps = 49/266 (18%) Query: 370 KIADTSEGGIYLGFYEKQEV--AVKTFCEGSPRAQR----EVSCLQSSRENSHLVTFYGS 423 ++ D + G +Y ++ V A K S E+ L S ++ ++V + Sbjct: 44 ELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASC-DHPNIVKLLDA 102 Query: 424 ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTH 483 + +L++ + C +D E + + V A+ LH + H Sbjct: 103 FYYENNLWILIEFCAGGA---VDAVMLELERPLTESQIQVVCKQTLDALNYLHDN-KIIH 158 Query: 484 QDLQPQNILIDSKKAAHLADFDKSIKWAGD---------------------------PQE 516 +DL+ NIL LADF S K P + Sbjct: 159 RDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYD 218 Query: 517 VKRDLEDLGRLVLYVVKKGSISFEDLK------AQSNEEVVQLSP----DEETKDLIHRL 566 K D+ LG + L + + +L + E L+ KD + + Sbjct: 219 YKADVWSLG-ITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKC 277 Query: 567 FHPGEHVRDCLSDLLGHPFFWTWESR 592 R S LL HPF ++ Sbjct: 278 LEKNVDARWTTSQLLQHPFVTVDSNK 303 >2JDO-A nrPDB Length = 342 Score = 121 bits (303), Expect = 1e-27, Method: Composition-based stats. Identities = 43/252 (17%), Positives = 87/252 (34%), Gaps = 43/252 (17%) Query: 371 IADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHL 430 + + + G Y ++EV + + E LQ++R + L + L Sbjct: 29 VREKATGRYYAMKILRKEVIIAK--DEVAHTVTESRVLQNTR-HPFLTALKYAFQTHDRL 85 Query: 431 FVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQN 490 + L H + E+ AR + I A++ LH S ++D++ +N Sbjct: 86 CFVMEYANGG---ELFFHLSRERVFTEER-ARFYGAEIVSALEYLH-SRDVVYRDIKLEN 140 Query: 491 ILIDSKKAAHLADFDKSIK----------WAGDPQEV------------KRDLEDLGRLV 528 +++D + DF + + G P+ + D LG +V Sbjct: 141 LMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLG-VV 199 Query: 529 LYVVKKGSISFEDLKAQSNEEVV-------QLSPDEETKDLIHRLFHPGEHVRD-----C 576 +Y + G + F + + E++ + E K L+ L R Sbjct: 200 MYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSD 259 Query: 577 LSDLLGHPFFWT 588 +++ H FF + Sbjct: 260 AKEVMEHRFFLS 271 >3HDN-A nrPDB Length = 373 Score = 121 bits (303), Expect = 1e-27, Method: Composition-based stats. Identities = 53/259 (20%), Positives = 91/259 (35%), Gaps = 48/259 (18%) Query: 370 KIADTSEGGIYLGFYEKQEV--AVKTFCEGSPRAQREVSCLQSSR-------ENSHLVTF 420 I S G + L ++ +EV AVK + + ++E + S R ++ LV Sbjct: 45 VIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGL 104 Query: 421 YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG 480 + S L+ + + + + AR + I A+ LH S Sbjct: 105 HFSFQTADKLYFVLDYINGGE----LFYHLQRERCFLEPRARFYAAEIASALGYLH-SLN 159 Query: 481 YTHQDLQPQNILIDSKKAAHLADFDKSIK----------WAGDPQEVK------------ 518 ++DL+P+NIL+DS+ L DF + + G P+ + Sbjct: 160 IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRT 219 Query: 519 RDLEDLGRLVLYVVKKGSISFEDLKAQSNEE-----VVQLSPD--EETKDLIHRLFHPGE 571 D LG + LY + G F + +QL P+ + L+ L Sbjct: 220 VDWWCLGAV-LYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDR 278 Query: 572 HVR----DCLSDLLGHPFF 586 R D ++ H FF Sbjct: 279 TKRLGAKDDFMEIKSHVFF 297 >4AGU-A nrPDB Length = 311 Score = 121 bits (303), Expect = 1e-27, Method: Composition-based stats. Identities = 56/316 (17%), Positives = 97/316 (30%), Gaps = 82/316 (25%) Query: 367 EKY----KIADTSEGGIYL--GFYEKQEVAVKTFCE------GSPRAQREVSCLQSSREN 414 EKY KI + S G ++ Q VA+K F E A RE+ L+ ++ Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQL-KH 61 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 +LV + L + C+ T+ LD ++ + +++ +AV Sbjct: 62 PNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQR----GVPEHLVKSITWQTLQAVNF 117 Query: 475 LHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAG---------------------- 512 H H+D++P+NILI L DF + G Sbjct: 118 CH-KHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVG 176 Query: 513 -DPQEVKRDLEDLGRLVLYVVK-----KGSISFEDLK--AQSNEEVVQLS---------- 554 D+ +G + ++ G + L ++ +++ Sbjct: 177 DTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYF 236 Query: 555 -----PDEE---------------TKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYR 594 PD E L+ H R LL HP+F R Sbjct: 237 SGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYF----ENIR 292 Query: 595 TLRNVGNESDIKTRKS 610 + ++ E D Sbjct: 293 EIEDLAKEHDKPAENL 308 >5G6V-A nrPDB Length = 324 Score = 121 bits (303), Expect = 1e-27, Method: Composition-based stats. Identities = 55/300 (18%), Positives = 99/300 (33%), Gaps = 74/300 (24%) Query: 369 YKIADTSEGGIYLGFYEKQE--VAVKTFC----EGSP-RAQREVSCLQSSRENSHLVTFY 421 K+ + + +Y G + + VA+K EG+P A REVS L+ +++++VT + Sbjct: 8 DKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDL-KHANIVTLH 66 Query: 422 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 L + ++ L+ LD + L + + + H Sbjct: 67 DIIHTEKSLTLVFEYLDKDLKQYLDDCG----NIINMHNVKLFLFQLLRGLAYCHR-QKV 121 Query: 482 THQDLQPQNILIDSKKAAHLADFDKSIK-----------------------WAGDPQEVK 518 H+DL+PQN+LI+ + LADF + + Sbjct: 122 LHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDYSTQ 181 Query: 519 RDLEDLGRLVLYVVKKGSISFEDLKAQ-------------SNEEVVQLSPDEETK----- 560 D+ +G + Y + G F + + E + +EE K Sbjct: 182 IDMWGVGCIF-YEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYP 240 Query: 561 -------------------DLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGN 601 DL+ +L R D + HPFF + R L + + Sbjct: 241 KYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTS 300 >5KKR-C nrPDB Length = 395 Score = 121 bits (303), Expect = 1e-27, Method: Composition-based stats. Identities = 55/308 (17%), Positives = 98/308 (31%), Gaps = 85/308 (27%) Query: 358 IGKLKFFIDEKY-KIADTSEGGIYLGFYEKQE--VAVKTF-CEGSPRAQ----REVSCLQ 409 +G+LK EK ++ + G ++ ++ +A K E P + RE+ L Sbjct: 62 VGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLH 121 Query: 410 SSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIF 469 + ++V FYG+ G + +C+ + LD + E + ++ + Sbjct: 122 EC-NSPYIVGFYGAFYSDGEISICMEHMDGGS---LDQVLKKAGRIPEQILGKVSIA-VI 176 Query: 470 KAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS--------------------IK 509 K + L H+D++P NIL++S+ L DF S + Sbjct: 177 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPER 236 Query: 510 WAGDPQEVKRDLEDLGRLVLYVVKKGSIS------------------------------- 538 G V+ D+ +G L L + G Sbjct: 237 LQGTHYSVQSDIWSMG-LSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTP 295 Query: 539 -----------------FEDLKAQSNEEVVQLSP---DEETKDLIHRLFHPGEHVRDCLS 578 FE L NE +L E +D +++ R L Sbjct: 296 GRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLK 355 Query: 579 DLLGHPFF 586 L+ H F Sbjct: 356 QLMVHAFI 363 >3UTO-A nrPDB Length = 573 Score = 121 bits (303), Expect = 1e-27, Method: Composition-based stats. Identities = 47/274 (17%), Positives = 89/274 (32%), Gaps = 50/274 (18%) Query: 365 IDEKYKIADTSEGGIYLGFYEKQEVAVK--------TFCEGSPR--AQREVSCLQSSREN 414 + + Y I + G + + E A S + ++E+ + R + Sbjct: 155 VLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLR-H 213 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 LV + + + + + E + EDE A + + K + Sbjct: 214 PTLVNLHDAFEDDNEMVMIYEFMSGG--ELFEKVADEHNKMSEDE-AVEYMRQVCKGLCH 270 Query: 475 LHLSCGYTHQDLQPQNILIDSK--KAAHLADFDKSIKW---------------------A 511 +H + Y H DL+P+NI+ +K L DF + Sbjct: 271 MHEN-NYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAE 329 Query: 512 GDPQEVKRDLEDLGRLVLYVVKKGSISF------EDLKAQSNEEVVQ-----LSPDEETK 560 G P D+ +G ++ Y++ G F E L+ + + E+ K Sbjct: 330 GKPVGYYTDMWSVG-VLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGK 388 Query: 561 DLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYR 594 D I +L + R + L HP+ + R Sbjct: 389 DFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGR 422 >5DBX-A nrPDB Length = 328 Score = 121 bits (303), Expect = 1e-27, Method: Composition-based stats. Identities = 51/313 (16%), Positives = 102/313 (32%), Gaps = 64/313 (20%) Query: 370 KIADTSEGGIYLGFYEKQE--VAVKTF-CEGSPRA----QREVSCLQSSRENSHLVTFYG 422 I + + + ++ VA+K E + +E+ + + ++VT+Y Sbjct: 18 VIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCS-HPNVVTYYT 76 Query: 423 SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENE----EDEFARNVLSSIFKAVQELHLS 478 S + L++ + L + + E++ E+ +L + + + LH + Sbjct: 77 SFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRN 136 Query: 479 CGYTHQDLQPQNILIDSKKAAHLADFDKS---------------IKWAGDP--------- 514 G H+DL+ NIL+ + +ADF S + G P Sbjct: 137 -GQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWMAPEVME 195 Query: 515 ----QEVKRDLEDLGRLVLYVVKKG------SISFEDLKAQSNEEVVQLSPDEE------ 558 + K D+ G + + G + L + L E Sbjct: 196 QVRGYDFKADMWSFGITAI-ELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMK 254 Query: 559 -----TKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNES-DIKTRKSES 612 + L+ R ++LL FF ++R + + + DI R + Sbjct: 255 KYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKV 314 Query: 613 EILRLLQPGPSEH 625 + PG S H Sbjct: 315 RRV----PGSSGH 323 >4U41-A nrPDB Length = 332 Score = 120 bits (302), Expect = 1e-27, Method: Composition-based stats. Identities = 48/291 (16%), Positives = 99/291 (34%), Gaps = 52/291 (17%) Query: 370 KIADTSEGGIYLGFYEK--QEVAVKTFCEGSPR---AQREVSCLQSSRENSHLVTFYGSE 424 + + + G +Y G + K Q A+K + E++ L+ + ++ T+YG+ Sbjct: 31 VVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAF 90 Query: 425 S------HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLS 478 H L++ + C + D+ + ++++ + I + + LH+ Sbjct: 91 IKKSPPGHDDQLWLVMEFCGAG--SITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIH 148 Query: 479 CGYTHQDLQPQNILIDSKKAAHLADFDKSIKWA----------GDP-------------- 514 H+D++ QN+L+ L DF S + G P Sbjct: 149 H-VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 207 Query: 515 ---QEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDE---------ETKDL 562 + + DL G + + +G+ D+ ++ +P + Sbjct: 208 DATYDYRSDLWSCGITAI-EMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSF 266 Query: 563 IHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESE 613 I R LL HPF + + + + D +TRK E Sbjct: 267 IEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHID-RTRKKRGE 316 >4XBR-A nrPDB Length = 366 Score = 120 bits (302), Expect = 2e-27, Method: Composition-based stats. Identities = 55/287 (19%), Positives = 105/287 (36%), Gaps = 46/287 (16%) Query: 337 KPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEK--QEVAVKTF 394 +PQ L + P G + ++D KI + S G + + + VAVK Sbjct: 70 EPQRVSHEQFRAALQLVVDP--GDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM 127 Query: 395 CEGSPRAQREV----SCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRG 450 + + +RE+ + ++ ++V Y S L+V + E + H Sbjct: 128 -DLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR 186 Query: 451 EDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKW 510 + E++ A L+ + +A+ LH + G H+D++ +IL+ L+DF + Sbjct: 187 MN----EEQIAAVCLA-VLQALSVLH-AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV 240 Query: 511 A----------GDPQEV------------KRDLEDLGRLVLYVVKK-----GSISFEDLK 543 + G P + + D+ LG +V+ +V + +K Sbjct: 241 SKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMK 300 Query: 544 AQSNEEVVQLSP----DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + +L K + RL R ++LL HPF Sbjct: 301 MIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 347 >6FD3-A nrPDB Length = 300 Score = 120 bits (302), Expect = 2e-27, Method: Composition-based stats. Identities = 49/255 (19%), Positives = 87/255 (34%), Gaps = 46/255 (18%) Query: 370 KIADTSEGGIY--LGFYEKQEVAVKTF-CEGSPRAQ---REVSCLQSSRENSHLVTFYGS 423 KI + G +Y L QEVA+K + P+ + E+ + +N ++V + S Sbjct: 29 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEI-LVMRENKNPNIVNYLDS 87 Query: 424 ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTH 483 L+V + + E +E A V +A+ LH + H Sbjct: 88 YLVGDELWVVMEYLAGGSLTDV---VTETCMDEGQIAA--VCRECLQALDFLHSNQ-VIH 141 Query: 484 QDLQPQNILIDSKKAAHLADFDKSIKWA----------GDPQEV------------KRDL 521 +D++ NIL+ + L DF + G P + K D+ Sbjct: 142 RDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDI 201 Query: 522 EDLGRLVLYVVKKGSISF------EDLKAQSNEEVVQLSP----DEETKDLIHRLFHPGE 571 LG ++ + +G + L + +L +D ++R Sbjct: 202 WSLG-IMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDV 260 Query: 572 HVRDCLSDLLGHPFF 586 R +LL HPF Sbjct: 261 DRRGSAKELLQHPFL 275 >4WNO-A nrPDB Length = 287 Score = 120 bits (302), Expect = 2e-27, Method: Composition-based stats. Identities = 55/277 (19%), Positives = 94/277 (33%), Gaps = 57/277 (20%) Query: 358 IGKLKFFIDEKYKIADTSEGGIYLGFYEKQ---EVAVKTFCEGS-----PRAQREVSCLQ 409 +GK +F K I + ++ G + EVAVK + + +E+ L+ Sbjct: 15 VGKFEF--SRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILK 72 Query: 410 SSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIF 469 ++ ++V Y + +++ + C L + ED R L I Sbjct: 73 EL-KHENIVALYDFQEMANSVYLVMEYCNGG---DLADYLHAMRTLSEDTI-RLFLQQIA 127 Query: 470 KAVQELHLSCGYTHQDLQPQNILIDSKKA---------AHLADFDK---------SIKWA 511 A++ LH S G H+DL+PQNIL+ + +ADF + Sbjct: 128 GAMRLLH-SKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLC 186 Query: 512 GDPQEV------------KRDLEDLGRLVLYVVKKGSISFEDL----------KAQSNEE 549 G P + K DL +G +V Y G F+ K ++ Sbjct: 187 GSPMYMAPEVIMSQHYDGKADLWSIGTIV-YQCLTGKAPFQASSPQDLRLFYEKNKTLVP 245 Query: 550 VVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + + L+ L R + HPF Sbjct: 246 TIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL 282 >6DTL-A nrPDB Length = 364 Score = 120 bits (302), Expect = 2e-27, Method: Composition-based stats. Identities = 50/318 (15%), Positives = 101/318 (31%), Gaps = 90/318 (28%) Query: 363 FFIDEKYK-----IADTSEGGIYLGF--YEKQEVAVKTFCE------GSPRAQREVSCLQ 409 F + KYK I + G + + VA+K + R RE+ L+ Sbjct: 25 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 84 Query: 410 SSRENSHLVTFYGSESHR-----GHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNV 464 ++ ++V +++ L + L + R +EE + Sbjct: 85 HM-DHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQ---IIRSNQALSEE--HCQYF 138 Query: 465 LSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS--------------IKW 510 L I + ++ +H S H+DL+P N+L+++ + DF + +W Sbjct: 139 LYQILRGLKYIH-SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW 197 Query: 511 AGDPQEV--------KRDLEDLGRLVL-----YVVKKGSISFEDLK-------------- 543 P+ + D+ +G + + + G L+ Sbjct: 198 YRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEEL 257 Query: 544 ----AQSNEEVVQLSPDEE-------------TKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + + QL P DLI ++ R + D L HP+ Sbjct: 258 EFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPY- 316 Query: 587 WTWESRYRTLRNVGNESD 604 +L ++ +E + Sbjct: 317 ------LNSLHDISDEPE 328 >1KOB-A nrPDB Length = 387 Score = 120 bits (301), Expect = 2e-27, Method: Composition-based stats. Identities = 55/312 (17%), Positives = 103/312 (33%), Gaps = 66/312 (21%) Query: 365 IDEKYKIADTSEGGIYLGFYEKQEVAVKTFCE----------GSPRAQREVSCLQSSREN 414 + + Y I + G + + E A + E+S + + Sbjct: 49 VYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKNEISIMNQLH-H 107 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 L+ + + + + + + D ED + E E N + + ++ Sbjct: 108 PKLINLHDAFEDKYEMVLILEFLSGG--ELFDRIAAEDYKMSEAEV-INYMRQACEGLKH 164 Query: 475 LHLSCGYTHQDLQPQNILIDSKKA--AHLADFDKSIKWAGD--------------PQEVK 518 +H H D++P+NI+ ++KKA + DF + K D P+ V Sbjct: 165 MHE-HSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIVD 223 Query: 519 R-------DLEDLGRLVLYVVKKGSISF------EDLKAQSNEEV-----VQLSPDEETK 560 R D+ +G ++ YV+ G F E L+ + S E K Sbjct: 224 REPVGFYTDMWAIG-VLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSSVSPEAK 282 Query: 561 DLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQP 620 D I L R + D L HP+ G+ S++ +R S ++ Q Sbjct: 283 DFIKNLLQKEPRKRLTVHDALEHPWL------------KGDHSNLTSRIPSSRYNKIRQK 330 Query: 621 GPSEHSKSFDKW 632 + + W Sbjct: 331 ----IKEKYADW 338 >6CCF-A nrPDB Length = 290 Score = 120 bits (300), Expect = 3e-27, Method: Composition-based stats. Identities = 47/243 (19%), Positives = 83/243 (34%), Gaps = 45/243 (18%) Query: 381 LGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESH--RGHLFVCVTLCE 438 G Q K R +E++ L+ ++ ++V +L++ L Sbjct: 56 RGSQAAQGGPAKQLLP-LERVYQEIAILKKL-DHVNVVKLIEVLDDPAEDNLYLVFDLLR 113 Query: 439 QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA 498 + V + +E AR L + ++ LH H+D++P N+L+ Sbjct: 114 KGP-----VMEVPCDKPFSEEQARLYLRDVILGLEYLHC-QKIVHRDIKPSNLLLGDDGH 167 Query: 499 AHLADFDKSIKWAGD---------------PQEVKR----------DLEDLGRLVLYVVK 533 +ADF S ++ G+ P+ + D+ G + LY Sbjct: 168 VKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATG-VTLYCFV 226 Query: 534 KGSISFED-----LKAQSNEEVVQLSP----DEETKDLIHRLFHPGEHVRDCLSDLLGHP 584 G F D L + E V EE KDLI ++ R + D+ HP Sbjct: 227 YGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHP 286 Query: 585 FFW 587 + Sbjct: 287 WVT 289 >1KOA-A nrPDB Length = 491 Score = 119 bits (299), Expect = 4e-27, Method: Composition-based stats. Identities = 46/274 (16%), Positives = 88/274 (32%), Gaps = 50/274 (18%) Query: 365 IDEKYKIADTSEGGIYLGFYEKQEVA----------VKTFCEGSPRAQREVSCLQSSREN 414 + + Y I + G + + E A + ++E+ + R + Sbjct: 49 VLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLR-H 107 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 LV + + + + + E + EDE A + + K + Sbjct: 108 PTLVNLHDAFEDDNEMVMIYEFMSGG--ELFEKVADEHNKMSEDE-AVEYMRQVCKGLCH 164 Query: 475 LHLSCGYTHQDLQPQNILIDSK--KAAHLADFDKSIKW---------------------A 511 +H + Y H DL+P+NI+ +K L DF + Sbjct: 165 MHEN-NYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAE 223 Query: 512 GDPQEVKRDLEDLGRLVLYVVKKGSISF------EDLKAQSNEEVVQ-----LSPDEETK 560 G P D+ +G ++ Y++ G F E L+ + + E+ K Sbjct: 224 GKPVGYYTDMWSVG-VLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGK 282 Query: 561 DLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYR 594 D I +L + R + L HP+ + R Sbjct: 283 DFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGR 316 >6E9W-A nrPDB Length = 443 Score = 119 bits (298), Expect = 5e-27, Method: Composition-based stats. Identities = 55/318 (17%), Positives = 106/318 (33%), Gaps = 67/318 (21%) Query: 354 YRPMIGKLKFF--IDEKYKIADTSEGGIYLGFY-----EKQEVAVKTFCEGSPRAQR--- 403 Y+ I K++ E Y++ G + ++V +R Sbjct: 87 YKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDS 146 Query: 404 ----EVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDE 459 E + + + +V + + +L++ + D+ + ++ Sbjct: 147 AFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGG-----DLVNLMSNYDVPEK 201 Query: 460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWA-------- 511 +AR + + A+ +H S G+ H+D++P N+L+D LADF +K Sbjct: 202 WARFYTAEVVLALDAIH-SMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCD 260 Query: 512 ---GDPQEV----------------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQ 552 G P + + D +G + LY + G F + Sbjct: 261 TAVGTPDYISPEVLKSQGGDGYYGRECDWWSVG-VFLYEMLVGDTPFYADSLVGTYSKIM 319 Query: 553 LS-----------PDEETKDLIHRLFHPGEHV--RDCLSDLLGHPFF----WTWESRYRT 595 +E K+LI E R+ + ++ H FF W WE+ T Sbjct: 320 NHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDT 379 Query: 596 LRNVGNE--SDIKTRKSE 611 + V + SDI T + Sbjct: 380 VAPVVPDLSSDIDTSNFD 397 >6BDL-A nrPDB Length = 347 Score = 119 bits (297), Expect = 6e-27, Method: Composition-based stats. Identities = 52/267 (19%), Positives = 94/267 (35%), Gaps = 54/267 (20%) Query: 368 KYKIADTSEGGIY-------LGFYEKQEVAVKTFCE---GSPRAQREVSCLQSSRENSH- 416 + I DT G + L E + A+K + R Q + + + +H Sbjct: 35 DFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHS 94 Query: 417 --LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 +V Y + +L++ + C D + ED R + + +A Sbjct: 95 DFIVRLYRTFKDSKYLYMLMEACLGGE----LWTILRDRGSFEDSTTRFYTACVVEAFAY 150 Query: 475 LHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK---------WAGDPQEV-------- 517 LH S G ++DL+P+N+++D + A L DF + K + G P+ V Sbjct: 151 LH-SKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNK 209 Query: 518 ----KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPD---------EETKDLIH 564 D LG +++Y + GS F ++ D + +LI Sbjct: 210 GHDISADYWSLG-ILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIK 268 Query: 565 RLFHPGEHVRD-----CLSDLLGHPFF 586 +L R + D+ H +F Sbjct: 269 KLCRDNPSERLGNLKNGVKDIQKHKWF 295 >1ZXE-A nrPDB Length = 303 Score = 119 bits (297), Expect = 7e-27, Method: Composition-based stats. Identities = 52/281 (18%), Positives = 90/281 (32%), Gaps = 70/281 (24%) Query: 370 KIADTSEGGIYLGF--YEKQEVAVKTFC---EGSPRAQREVSCLQSSRENSHLVTFYGS- 423 + + G + + + A+K E EV L +S + ++V +Y + Sbjct: 13 VLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLL-ASLNHQYVVRYYAAW 71 Query: 424 ESHRGH------------LFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 471 R LF+ + CE D+ E++ + DE+ R + I +A Sbjct: 72 LERRNFVKPMTAVKKKSTLFIQMEYCEN--RTLYDLIHSENLNQQRDEYWR-LFRQILEA 128 Query: 472 VQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWA-------------------- 511 + +H S G H++L+P NI ID + + DF + Sbjct: 129 LSYIH-SQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNL 187 Query: 512 ----GDPQEV-------------KRDLEDLGRLVL---YVVKKGSISFEDLKAQSNEEVV 551 G V K D+ LG + Y G LK + + Sbjct: 188 TSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIYPFSTGMERVNILKKLRSV-SI 246 Query: 552 QLSPD------EETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + PD + K +I L + R LL + Sbjct: 247 EFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL 287 >3ZDU-A nrPDB Length = 325 Score = 118 bits (296), Expect = 7e-27, Method: Composition-based stats. Identities = 54/286 (18%), Positives = 94/286 (32%), Gaps = 75/286 (26%) Query: 370 KIADTSEGGIYLGFYEK--QEVAVKTFCE-----GSPRAQREVSCLQSSRENSHLVTFYG 422 K+ + S G + ++ Q VA+K F E + A RE+ L+ + +LV Sbjct: 10 KVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFH-HENLVNLIE 68 Query: 423 SESHRGHLFVCVTLCEQT-LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 + + + + T L+ G E + R L I +A+ LH S Sbjct: 69 VFRQKKKIHLVFEFIDHTVLDELQHYCHGL-----ESKRLRKYLFQILRAIDYLH-SNNI 122 Query: 482 THQDLQPQNILIDSKKAAHLADFDKSIKWAG-----------------------DPQEVK 518 H+D++P+NIL+ L DF + A Sbjct: 123 IHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYGKP 182 Query: 519 RDLEDLGRLVL--------------------YVVKKGSIS------FEDLKAQSNEEVVQ 552 D+ LG +++ V+K G++S F + + Q Sbjct: 183 VDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQ 242 Query: 553 LSPDEETK-----------DLIHRLFHPGEHVRDCLSDLLGHPFFW 587 + + + D++H R SDLL H +F Sbjct: 243 VQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFT 288 >6CQF-A nrPDB Length = 297 Score = 118 bits (296), Expect = 8e-27, Method: Composition-based stats. Identities = 46/264 (17%), Positives = 92/264 (34%), Gaps = 54/264 (20%) Query: 367 EKYKIADTSEGGIYLGFYEKQE------VAVKTF----CEGSPRAQREVSCLQSSRENSH 416 + Y + GG Y ++ ++ VA+K + Q+E+ L++ R +++ Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR-HAN 74 Query: 417 LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 +V ++GS L++C+ C + D++ + + + V + + + LH Sbjct: 75 IVAYHGSYLWLQKLWICMEFCGAG--SLQDIY--QVTGSLSELQISYVCREVLQGLAYLH 130 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWA----------GDPQEVK-------- 518 S H+D++ NILI+ LADF S + G P + Sbjct: 131 -SQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVAL 189 Query: 519 -------RDLEDLGRLVLYVVKKGSISFED--------LKAQSNEEVVQLSP----DEET 559 D+ LG + + + D L +S + +L Sbjct: 190 KGGYNELCDIWSLGITAI-ELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAF 248 Query: 560 KDLIHRLFHPGEHVRDCLSDLLGH 583 + I R + +L H Sbjct: 249 HNFIKVTLTKSPKKRPSATKMLSH 272 >6ED6-A nrPDB Length = 415 Score = 118 bits (296), Expect = 9e-27, Method: Composition-based stats. Identities = 55/318 (17%), Positives = 104/318 (32%), Gaps = 67/318 (21%) Query: 354 YRPMIGKLK--FFIDEKYKIADTSEGGIYLGFYE-----KQEVAVKTFCEGSPRAQR--- 403 Y ++ K++ E Y + G + Q+V +R Sbjct: 73 YEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDS 132 Query: 404 ----EVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDE 459 E + + + +V + + +L++ + D+ + ++ Sbjct: 133 AFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGG-----DLVNLMSNYDVPEK 187 Query: 460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKW--------- 510 +A+ + + A+ +H S G H+D++P N+L+D LADF +K Sbjct: 188 WAKFYTAEVVLALDAIH-SMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCD 246 Query: 511 --AGDPQEV----------------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQ 552 G P + + D +G + LY + G F + Sbjct: 247 TAVGTPDYISPEVLKSQGGDGFYGRECDWWSVG-VFLYEMLVGDTPFYADSLVGTYSKIM 305 Query: 553 -------LSPDEE----TKDLIHRLFHPGEHV--RDCLSDLLGHPFF----WTWESRYRT 595 D E K+LI E R+ + ++ HPFF W W++ T Sbjct: 306 DHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRET 365 Query: 596 LRNVGNE--SDIKTRKSE 611 V E SDI + + Sbjct: 366 AAPVVPELSSDIDSSNFD 383 >3BGP-A nrPDB Length = 333 Score = 118 bits (295), Expect = 9e-27, Method: Composition-based stats. Identities = 50/268 (18%), Positives = 93/268 (34%), Gaps = 45/268 (16%) Query: 359 GKLKFFIDEKYKIADTSEGGIYLGFY------EKQEVAVKTFCEG----------SPRAQ 402 GK K ++ +Y++ G + Y + VA+K + R Sbjct: 48 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 107 Query: 403 REVSCLQS-SRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFA 461 EV L+ S S ++ + + + ++ D + ++E A Sbjct: 108 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILER-PEPVQDLFDFIT--ERGALQEELA 164 Query: 462 RNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK-KAAHLADFDKSIKWAGD------- 513 R+ + +AV+ H +CG H+D++ +NILID L DF Sbjct: 165 RSFFWQVLEAVRHCH-NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDG 223 Query: 514 ------PQEVK--------RDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVV-QLSPDEE 558 P+ ++ + LG ++LY + G I FE + +V + E Sbjct: 224 TRVYSPPEWIRYHRYHGRSAAVWSLG-ILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSE 282 Query: 559 TKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + LI R ++ HP+ Sbjct: 283 CQHLIRWCLALRPSDRPTFEEIQNHPWM 310 >1G3N-A nrPDB Length = 326 Score = 118 bits (295), Expect = 1e-26, Method: Composition-based stats. Identities = 59/300 (19%), Positives = 100/300 (33%), Gaps = 78/300 (26%) Query: 366 DEKYKIADTSEGGIYLGFYEKQE-------VAVKTFC-----EGSP-RAQREVSCLQSSR 412 D++Y+ G Y ++ ++ VA+K EG P REV+ L+ Sbjct: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 Query: 413 --ENSHLVTFYGS-----ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVL 465 E+ ++V + L + +Q L LD V E ++++ Sbjct: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTET---IKDMM 126 Query: 466 SSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS--------------IKWA 511 + + + LH S H+DL+PQNIL+ S LADF + W Sbjct: 127 FQLLRGLDFLH-SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWY 185 Query: 512 GDPQEVKR-------DLEDLGRLV--------LY-----------VVKKGSISFEDL--- 542 P+ + + DL +G + L+ ++ + E+ Sbjct: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 Query: 543 -----------KAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWES 591 K+ E DE KDL+ + R L HP+F E Sbjct: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 >3OZ6-A nrPDB Length = 388 Score = 118 bits (295), Expect = 1e-26, Method: Composition-based stats. Identities = 54/346 (15%), Positives = 99/346 (28%), Gaps = 120/346 (34%) Query: 359 GKLKFFIDEKYKIADTSEGGIYLGFYEK------QEVAVKTFCE------GSPRAQREVS 406 G++ + KY++ G Y ++ + VAVK + + R RE+ Sbjct: 1 GRVDRHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIM 60 Query: 407 CLQSSRENSHLVTFYGSE--SHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNV 464 L + ++V + +++ E D+H E + V Sbjct: 61 ILTELSGHENIVNLLNVLRADNDRDVYLVFDYMET------DLHAVIRANILEPVHKQYV 114 Query: 465 LSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK--------------- 509 + + K ++ LH S G H+D++P NIL++++ +ADF S Sbjct: 115 VYQLIKVIKYLH-SGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSI 173 Query: 510 -----------------------------WAGDPQEVKRDLEDLGRLVLYVVKKGSI--- 537 D+ LG +L + G Sbjct: 174 NENTENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGC-ILGEILCGKPIFP 232 Query: 538 ----------------------------SFEDLKAQSNEEVVQLSPD------------- 556 F +S +E V++ Sbjct: 233 GSSTMNQLERIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLL 292 Query: 557 ----------EETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESR 592 EE DL+ +L + R +D L HPF + + Sbjct: 293 LKINPKADCNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNP 338 >4ZSG-A nrPDB Length = 347 Score = 118 bits (295), Expect = 1e-26, Method: Composition-based stats. Identities = 49/314 (15%), Positives = 96/314 (30%), Gaps = 89/314 (28%) Query: 361 LKFFIDEKYKIADTSEGGIY------LGFYEKQEVAVKTFCEG------SPRAQREVSCL 408 + F + ++Y+I +T G Y Q+VA+K + R RE+ L Sbjct: 1 VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKIL 60 Query: 409 QSSRENSHLVTFYGSESHR------GHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFAR 462 + ++ +++ ++V + L E L +H + + E R Sbjct: 61 KHF-KHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDL--HQIIHSSQPLTLE---HVR 114 Query: 463 NVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDP-------- 514 L + + ++ +H S H+DL+P N+L++ + DF + P Sbjct: 115 YFLYQLLRGLKYMH-SAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMT 173 Query: 515 -------------------QEVKRDLEDLGRLV--------------------LYVVKKG 535 DL +G + L ++ G Sbjct: 174 EYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLG 233 Query: 536 SIS---------------FEDLKAQSNEEVVQLSP--DEETKDLIHRLFHPGEHVRDCLS 578 + S + L + + P D + L+ R+ R + Sbjct: 234 TPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAA 293 Query: 579 DLLGHPFFWTWESR 592 L HPF + Sbjct: 294 AALRHPFLAKYHDP 307 >5F9E-A nrPDB Length = 353 Score = 118 bits (295), Expect = 1e-26, Method: Composition-based stats. Identities = 50/264 (18%), Positives = 90/264 (34%), Gaps = 49/264 (18%) Query: 366 DEKYKIADTSEGGIYLGFY------EKQEVAVKTFCEGSPRAQREVSC-------LQSSR 412 E +++ G + + Q A+K + +V C L + Sbjct: 18 IEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAW 77 Query: 413 ENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAV 472 E+ L + + + +LF + L ++ + + A + I + Sbjct: 78 EHPFLTHMFCTFQTKENLFFVMEY----LNGGDLMYHIQSCHKFDLSRATFYAAEIILGL 133 Query: 473 QELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI----------KWAGDPQEV----- 517 Q LH S G ++DL+ NIL+D +ADF ++ G P + Sbjct: 134 QFLH-SKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEIL 192 Query: 518 -------KRDLEDLGRLVLYVVKKGSISF-----EDLKAQSNEEVVQLS--PDEETKDLI 563 D G ++LY + G F E+L + ++E KDL+ Sbjct: 193 LGQKYNHSVDWWSFG-VLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLL 251 Query: 564 HRLFHPGEHVRDCLS-DLLGHPFF 586 +LF R + D+ HP F Sbjct: 252 VKLFVREPEKRLGVRGDIRQHPLF 275 >1S9I-A nrPDB Length = 354 Score = 117 bits (294), Expect = 1e-26, Method: Composition-based stats. Identities = 59/354 (16%), Positives = 108/354 (30%), Gaps = 106/354 (29%) Query: 355 RPMIGKLKFFIDEKY-KIADTSEGGIYLGFYEKQE--VAVKTF-CEGSPRAQ----REVS 406 + +G+LK E+ ++ + G + + +A K E P + RE+ Sbjct: 7 KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ 66 Query: 407 CLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLS 466 L + ++V FYG+ G + +C+ + LD E E+ + ++ Sbjct: 67 VLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGS---LDQVLKEAKRIPEEILGKVSIA 122 Query: 467 SIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS------------------- 507 + + + L H+D++P NIL++S+ L DF S Sbjct: 123 -VLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMA 181 Query: 508 -IKWAGDPQEVKRDLEDLGRLVLYVVKKGSIS---------------------------- 538 + G V+ D+ +G L L + G Sbjct: 182 PERLQGTHYSVQSDIWSMG-LSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSI 240 Query: 539 ------------------------FEDLKAQSNEEVVQLSP---DEETKDLIHRLFHPGE 571 FE L NE +L + ++ +++ Sbjct: 241 SPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNP 300 Query: 572 HVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSES---EILRLLQPGP 622 R L L H F S+++ + LRL QPG Sbjct: 301 AERADLKMLTNHTFI--------------KRSEVEEVDFAGWLCKTLRLNQPGT 340 >5LOH-A nrPDB Length = 341 Score = 117 bits (293), Expect = 2e-26, Method: Composition-based stats. Identities = 56/299 (18%), Positives = 100/299 (33%), Gaps = 51/299 (17%) Query: 332 PAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAV 391 P K + A + ++RI P ++ F K I+ + G +YLG + AV Sbjct: 6 PTAGSKKEPGGGAATEEGVNRIAVPKPPSIEEFSIVK-PISRGAFGKVYLGQKGGKLYAV 64 Query: 392 KTFCEGSPRAQREVSCLQSSRE------NSHLVTFYGSESHRGHLFVCVTLCEQTLEACL 445 K + + +Q+ R+ + +V Y S ++++ + L Sbjct: 65 KVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSL 124 Query: 446 DVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFD 505 G ++E A +S + A+ LH G H+DL+P N+LI ++ L DF Sbjct: 125 LHIYG----YFDEEMAVKYISEVALALDYLHR-HGIIHRDLKPDNMLISNEGHIKLTDFG 179 Query: 506 KSI----------------KWAGDPQEV------------KRDLEDLGRLVLYVVKKGSI 537 S + G P + D LG L+ G Sbjct: 180 LSKVTLNRDINMMDILTTRTFCGTPDYLAPELLLGRAHGPAVDWWALGVC-LFEFLTGIP 238 Query: 538 SFEDLK--------AQSNEEVVQLSP--DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 F D + + + + + + L + R + +L HP F Sbjct: 239 PFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLF 297 >3A8W-A nrPDB Length = 345 Score = 117 bits (293), Expect = 2e-26, Method: Composition-based stats. Identities = 54/345 (15%), Positives = 103/345 (29%), Gaps = 77/345 (22%) Query: 359 GKLKFFIDEKYKIADTSEGGIYLGFY------EKQEVAVKTF-------CEGSPRAQREV 405 G + + + + G Y + A+K E Q E Sbjct: 1 GAMDPLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEK 60 Query: 406 SCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVL 465 + + + LV + LF + L H + E+ AR Sbjct: 61 HVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGG---DLMFHMQRQRKLPEE-HARFYS 116 Query: 466 SSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK----------WAGDPQ 515 + I A+ LH G ++DL+ N+L+DS+ L D+ + + G P Sbjct: 117 AEISLALNYLHE-RGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPN 175 Query: 516 EV------------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEV------------- 550 + D LG ++++ + G F+ + + N + Sbjct: 176 YIAPEILRGEDYGFSVDWWALG-VLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEK 234 Query: 551 ---VQLSPDEETKDLIHRLFHPGEHVRD------CLSDLLGHPFF----WTWESRYR--- 594 + S + ++ + R +D+ GHPFF W + + Sbjct: 235 QIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVP 294 Query: 595 -TLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINE 638 N+ E + S P + + D KI++ Sbjct: 295 PFKPNISGEFGLDNFDS------QFTNEPVQLTPDDDDIVRKIDQ 333 >5VO2-A nrPDB Length = 300 Score = 117 bits (293), Expect = 2e-26, Method: Composition-based stats. Identities = 45/243 (18%), Positives = 91/243 (37%), Gaps = 40/243 (16%) Query: 371 IADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHL 430 + ++G ++LG + +EVAVK + + ++ L+ ++ +++TF G + Sbjct: 20 VGSGAQGAVFLGRFHGEEVAVKKVRD---LKETDIKHLRKL-KHPNIITFKGVCTQAPCY 75 Query: 431 FVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQN 490 + + C Q + + G V I + LHL H+DL+ N Sbjct: 76 CILMEFCAQG-QLYEVLRAGRPVTPSLLVDWSM---GIAGGMNYLHL-HKIIHRDLKSPN 130 Query: 491 ILIDSKKAAHLADFDKSIKWA---------------------GDPQEVKRDLEDLGRLVL 529 +LI ++DF S + + +P K D+ G +VL Sbjct: 131 MLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFG-VVL 189 Query: 530 YVVKKGSISFEDLKAQS---------NEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDL 580 + + G I ++D+ + + V S + K L+ + ++ R + Sbjct: 190 WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI 249 Query: 581 LGH 583 L H Sbjct: 250 LLH 252 >6CKI-A nrPDB Length = 316 Score = 117 bits (292), Expect = 2e-26, Method: Composition-based stats. Identities = 47/272 (17%), Positives = 80/272 (29%), Gaps = 73/272 (26%) Query: 382 GFYEKQEVAVKTFCE----GSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLC 437 QE AVK + R REV L + + +++ ++ Sbjct: 34 NLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKM 93 Query: 438 EQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKK 497 + + + A V+ + A+ LH + G H+DL+P+NIL + Sbjct: 94 RGG----SILSHIHKRRHFNELEASVVVQDVASALDFLH-NKGIAHRDLKPENILCEHPN 148 Query: 498 A---AHLADFDK--SIKWAGD--------------------------------PQEVKRD 520 + DF IK GD + + D Sbjct: 149 QVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCD 208 Query: 521 LEDLGRLVLYVVKKGSIS------------------------FEDLKAQS--NEEVVQLS 554 L LG ++LY++ G FE ++ + Sbjct: 209 LWSLG-VILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAH 267 Query: 555 PDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 KDLI +L R + +L HP+ Sbjct: 268 ISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 299 >5X3F-B nrPDB Length = 393 Score = 117 bits (292), Expect = 2e-26, Method: Composition-based stats. Identities = 55/310 (17%), Positives = 101/310 (32%), Gaps = 52/310 (16%) Query: 371 IADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHL 430 + G Y ++ VK + E LQ+ LV S +L Sbjct: 103 VKHKESGNHYAMKILDKQKVVK--LKQIEHTLNEKRILQAV-NFPFLVKLEFSFKDNSNL 159 Query: 431 FVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQN 490 ++ + + + AR + I + LH S ++DL+P+N Sbjct: 160 YMVMEYVAGGEM----FSHLRRIGRFSEPHARFYAAQIVLTFEYLH-SLDLIYRDLKPEN 214 Query: 491 ILIDSKKAAHLADFDKSIK-------WAGDPQEV------------KRDLEDLGRLVLYV 531 +LID + + DF + + G P+ + D LG +++Y Sbjct: 215 LLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALG-VLIYE 273 Query: 532 VKKGSISFEDLKAQSNEEVV-------QLSPDEETKDLIHRLFHPGEHVR-----DCLSD 579 + G F + E + + KDL+ L R + ++D Sbjct: 274 MAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVND 333 Query: 580 LLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINEC 639 + H +F T + I RK E+ + + GP + S D +I Sbjct: 334 IKNHKWFAT-----------TDWIAIYQRKVEAPFIPKFK-GPGDTSNFDDYEEEEIRVS 381 Query: 640 VMKKMNKFYE 649 + +K K + Sbjct: 382 INEKCGKEFT 391 >4RC3-A nrPDB Length = 289 Score = 117 bits (292), Expect = 2e-26, Method: Composition-based stats. Identities = 49/267 (18%), Positives = 92/267 (34%), Gaps = 45/267 (16%) Query: 360 KLKFFIDEKYKIADTSEGGIYLGFY------EKQEVAVKTFCEG----------SPRAQR 403 K K ++ +Y++ G + Y + VA+K + R Sbjct: 5 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 64 Query: 404 EVSCLQS-SRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFAR 462 EV L+ S S ++ + + + ++ D + ++E AR Sbjct: 65 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILER-PEPVQDLFDFIT--ERGALQEELAR 121 Query: 463 NVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK-KAAHLADFDKSIKWAGD-------- 513 + + +AV+ H +CG H+D++ +NILID L DF Sbjct: 122 SFFWQVLEAVRHCH-NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGT 180 Query: 514 -----PQEVK--------RDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVV-QLSPDEET 559 P+ ++ + LG ++LY + G I FE + +V + E Sbjct: 181 RVYSPPEWIRYHRYHGRSAAVWSLG-ILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSEC 239 Query: 560 KDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + LI R ++ HP+ Sbjct: 240 QHLIRWCLALRPSDRPTFEEIQNHPWM 266 >5TUR-A nrPDB Length = 404 Score = 116 bits (291), Expect = 3e-26, Method: Composition-based stats. Identities = 50/268 (18%), Positives = 93/268 (34%), Gaps = 45/268 (16%) Query: 359 GKLKFFIDEKYKIADTSEGGIYLGFY------EKQEVAVKTFCEG----------SPRAQ 402 GK K ++ +Y++ G + Y + VA+K + R Sbjct: 119 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 178 Query: 403 REVSCLQS-SRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFA 461 EV L+ S S ++ + + + ++ D + ++E A Sbjct: 179 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILER-PEPVQDLFDFIT--ERGALQEELA 235 Query: 462 RNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK-KAAHLADFDKSIKWAGD------- 513 R+ + +AV+ H +CG H+D++ +NILID L DF Sbjct: 236 RSFFWQVLEAVRHCH-NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDG 294 Query: 514 ------PQEVK--------RDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVV-QLSPDEE 558 P+ ++ + LG ++LY + G I FE + +V + E Sbjct: 295 TRVYSPPEWIRYHRYHGRSAAVWSLG-ILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSE 353 Query: 559 TKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + LI R ++ HP+ Sbjct: 354 CQHLIRWCLALRPSDRPTFEEIQNHPWM 381 >1JNK-A nrPDB Length = 423 Score = 116 bits (291), Expect = 3e-26, Method: Composition-based stats. Identities = 55/383 (14%), Positives = 114/383 (29%), Gaps = 111/383 (28%) Query: 351 HRIYRPMIGKLKFFIDEKYK----IADTSEGGIYLGF--YEKQEVAVKTFCEG------S 398 ++ Y +G F + ++Y+ I ++G + + + VA+K + Sbjct: 46 NQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA 105 Query: 399 PRAQREVSCLQSSRENSHLVTFYGSESHR------GHLFVCVTLCEQTLEACLDVHRGED 452 RA RE+ L + ++++ + + +++ + L + L + + Sbjct: 106 KRAYREL-VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMEL--- 161 Query: 453 VENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAG 512 + E +L + ++ LH S G H+DL+P NI++ S + DF + Sbjct: 162 ----DHERMSYLLYQMLCGIKHLH-SAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT 216 Query: 513 ----DPQEVKR-----------------DLEDLGRL--------VLYV------------ 531 P V R D+ +G + +L+ Sbjct: 217 SFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI 276 Query: 532 --------------------VKKGSISFEDLKAQSNEEVVQLSPDEE--------TKDLI 563 + + L D E +DL+ Sbjct: 277 EQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLL 336 Query: 564 HRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPS 623 ++ R + D L HP+ W + +I Sbjct: 337 SKMLVIDPAKRISVDDALQHPYINVWYDP------------AEVEAPPPQI---YDKQLD 381 Query: 624 EHSKSFDKWTTKINECVMKKMNK 646 E + ++W I + VM K Sbjct: 382 EREHTIEEWKELIYKEVMNSEEK 404 >2F9G-A nrPDB Length = 353 Score = 116 bits (290), Expect = 4e-26, Method: Composition-based stats. Identities = 48/308 (15%), Positives = 99/308 (32%), Gaps = 91/308 (29%) Query: 368 KYKIADTSEGGIYLGFYEK--QEVAVKTF-----CEGSPRAQREVSCLQSSRENSHLVTF 420 K + + + G + ++ + VA+K + R RE+ L+ ++ +++T Sbjct: 16 KSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF-KHENIITI 74 Query: 421 Y-----GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 + S + +++ L + D+HR + D+ + + +AV+ L Sbjct: 75 FNIQRPDSFENFNEVYIIQELMQT------DLHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 Query: 476 HLSCGYTHQDLQPQNILIDSKKAAHLADFDK-------------------------SIKW 510 H S H+DL+P N+LI+S + DF + +W Sbjct: 129 HGS-NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 Query: 511 AGDP--------QEVKRDLEDLGRL---------------------VLYVVKKGSISFED 541 P D+ G + +++ + S D Sbjct: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Query: 542 LKA----QSNEEVVQLSPDEETK-------------DLIHRLFHPGEHVRDCLSDLLGHP 584 L+ ++ E + L DL+ R+ R + L HP Sbjct: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 Query: 585 FFWTWESR 592 + T+ Sbjct: 308 YLQTYHDP 315 >4QTB-A nrPDB Length = 380 Score = 116 bits (290), Expect = 4e-26, Method: Composition-based stats. Identities = 50/315 (15%), Positives = 103/315 (32%), Gaps = 87/315 (27%) Query: 357 MIGKLKFFIDEKYK----IADTSEGGIYLGF--YEKQEVAVKTFC-----EGSPRAQREV 405 M+ F + +Y I + + G + + K VA+K R RE+ Sbjct: 31 MVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREI 90 Query: 406 SCLQSSRENSHLVTFYG-----SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEF 460 L R + +++ + +++ L E D+++ + ++ Sbjct: 91 QILLRFR-HENVIGIRDILRASTLEAMRDVYIVQDLMET------DLYKLLKSQQLSNDH 143 Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDK-------------- 506 L I + ++ +H S H+DL+P N+LI++ + DF Sbjct: 144 ICYFLYQILRGLKYIH-SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFL 202 Query: 507 ----SIKWAGDP--------QEVKRDLEDLGRLVLYVVKK-------------------- 534 + +W P D+ +G ++ ++ Sbjct: 203 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 262 Query: 535 GSISFEDLK---------------AQSNEEVVQLSP--DEETKDLIHRLFHPGEHVRDCL 577 GS S EDL +++ +L P D + DL+ R+ + R + Sbjct: 263 GSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV 322 Query: 578 SDLLGHPFFWTWESR 592 + L HP+ + Sbjct: 323 EEALAHPYLEQYYDP 337 >4X7Q-B nrPDB Length = 312 Score = 116 bits (290), Expect = 4e-26, Method: Composition-based stats. Identities = 49/269 (18%), Positives = 87/269 (32%), Gaps = 47/269 (17%) Query: 360 KLKFFIDEKYKIADTSEGGIYLGFYEKQ------EVAVKTFCEG-----SPRAQR----- 403 K + + +Y++ G + + +VA+K SP + Sbjct: 24 KDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL 83 Query: 404 EVSCLQSSR---ENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEF 460 EV+ L + ++ + + + L + E E Sbjct: 84 EVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLE--RPLPAQDLFDYITEKGPLGEGP- 140 Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILID-SKKAAHLADFDKSIKWAGDPQE--- 516 +R + A+Q H S G H+D++ +NILID + A L DF +P Sbjct: 141 SRCFFGQVVAAIQHCH-SRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFD 199 Query: 517 ------------------VKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEV-VQLSPDE 557 + + LG ++LY + G I FE + E+ Sbjct: 200 GTRVYSPPEWISRHQYHALPATVWSLG-ILLYDMVCGDIPFERDQEILEAELHFPAHVSP 258 Query: 558 ETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + LI R P R L ++L P+ Sbjct: 259 DCCALIRRCLAPKPSSRPSLEEILLDPWM 287 >3Q53-A nrPDB Length = 306 Score = 115 bits (289), Expect = 5e-26, Method: Composition-based stats. Identities = 45/255 (17%), Positives = 86/255 (33%), Gaps = 46/255 (18%) Query: 370 KIADTSEGGIYLGF--YEKQEVAVKTF-CEGSPRAQ---REVSCLQSSRENSHLVTFYGS 423 KI + G +Y QEVA++ + P+ + E+ + +N ++V + S Sbjct: 28 KIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEI-LVMRENKNPNIVNYLDS 86 Query: 424 ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTH 483 L+V + + E +E A V +A++ LH + H Sbjct: 87 YLVGDELWVVMEYLAGGSLTDV---VTETCMDEGQIAA--VCRECLQALEFLHSNQ-VIH 140 Query: 484 QDLQPQNILIDSKKAAHLADFDKSIKWA----------GDPQEV------------KRDL 521 +D++ NIL+ + L DF + G P + K D+ Sbjct: 141 RDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDI 200 Query: 522 EDLGRLVLYVVKKGSISF------EDLKAQSNEEVVQLSP----DEETKDLIHRLFHPGE 571 LG ++ + +G + L + +L +D ++R Sbjct: 201 WSLG-IMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDV 259 Query: 572 HVRDCLSDLLGHPFF 586 R +L+ H F Sbjct: 260 EKRGSAKELIQHQFL 274 >3TXO-A nrPDB Length = 353 Score = 115 bits (289), Expect = 5e-26, Method: Composition-based stats. Identities = 54/318 (16%), Positives = 99/318 (31%), Gaps = 65/318 (20%) Query: 370 KIADTSEGGIYLGFYEKQE--VAVKTFCEGSPRAQREVSC-------LQSSRENSHLVTF 420 + S G + L ++ AVK + +V C L +R + L Sbjct: 30 VLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQL 89 Query: 421 YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG 480 + LF + + ++ AR + I A+ LH G Sbjct: 90 FCCFQTPDRLFFVMEFVNGGDLMF----HIQKSRRFDEARARFYAAEIISALMFLH-DKG 144 Query: 481 YTHQDLQPQNILIDSKKAAHLADFDKSIK----------WAGDPQEV------------K 518 ++DL+ N+L+D + LADF + + G P + Sbjct: 145 IIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPA 204 Query: 519 RDLEDLGRLVLYVVKKGSISFE-----DLKAQSNEEVVQLS--PDEETKDLIHRLFHPGE 571 D +G ++LY + G FE DL + V E+ ++ Sbjct: 205 VDWWAMG-VLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNP 263 Query: 572 HVRD-CLSD-----LLGHPFF----WTWESRYR----TLRNVGNESDIKTRKSE----SE 613 +R L+ +L HPFF W + + + + D+ + Sbjct: 264 TMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEP 323 Query: 614 ILRLLQPGPSEHSKSFDK 631 +L + G H ++ Sbjct: 324 VLTPIDEG---HLPMINQ 338 >3TKU-A nrPDB Length = 433 Score = 115 bits (288), Expect = 6e-26, Method: Composition-based stats. Identities = 61/319 (19%), Positives = 108/319 (33%), Gaps = 68/319 (21%) Query: 367 EKYKIADTSEGGIY------LGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRE------N 414 E ++I G + ++ A+K + + E +C + R+ Sbjct: 90 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 149 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 + + + HL++ + L + + ++ AR + + A+ Sbjct: 150 QWITALHYAFQDENHLYLVMDYYVGG---DLLTLLSKFEDKLPEDMARFYIGEMVLAIDS 206 Query: 475 LHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWA-----------GDPQEV------ 517 +H Y H+D++P N+L+D LADF +K G P + Sbjct: 207 IHQ-LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQ 265 Query: 518 -----------KRDLEDLGRLVLYVVKKGSISFEDL-------KAQSNEEVVQLSP---- 555 + D LG + Y + G F K ++EE Q Sbjct: 266 AMEDGMGKYGPECDWWSLGVCM-YEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTD 324 Query: 556 -DEETKDLIHRLFHPGEHV--RDCLSDLLGHPFF----WTWESRYR--TLRNVGNESDIK 606 EE KDLI RL E ++ + D H FF W + +V + SD Sbjct: 325 VSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTS 384 Query: 607 TRKSESEILR---LLQPGP 622 + ++LR +L PG Sbjct: 385 NFDVDDDVLRNTEILPPGS 403 >4BBM-A nrPDB Length = 331 Score = 115 bits (287), Expect = 1e-25, Method: Composition-based stats. Identities = 56/298 (18%), Positives = 95/298 (31%), Gaps = 78/298 (26%) Query: 361 LKFFIDEKYK----IADTSEGGIYL--GFYEKQEVAVKTFCE------GSPRAQREVSCL 408 L F EKY+ + + S G + + VA+K F E A RE+ L Sbjct: 19 LYFQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLL 78 Query: 409 QSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 + R + +LV + ++ + T+ L++ + + + L I Sbjct: 79 KQLR-HENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFP----NGLDYQVVQKYLFQI 133 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWA----------------- 511 + H S H+D++P+NIL+ L DF + A Sbjct: 134 INGIGFCH-SHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRA 192 Query: 512 -----GDPQEVKR-DLEDLGRLV--LY---VVKKGSISFEDLKA---------------- 544 GD + K D+ +G LV ++ + G + L Sbjct: 193 PELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELF 252 Query: 545 --------QSNEEVVQLSP--------DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 E+ + P E DL + H R ++LL H FF Sbjct: 253 NKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF 310 >5D9K-A nrPDB Length = 330 Score = 115 bits (287), Expect = 1e-25, Method: Composition-based stats. Identities = 52/273 (19%), Positives = 98/273 (35%), Gaps = 56/273 (20%) Query: 370 KIADTSEGGIYL-----GFYEKQEVAVKTFCE------GSPRAQREVSCLQSSRENSHLV 418 + S G ++L G +Q A+K + R + E L + +V Sbjct: 37 VLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEV-NHPFIV 95 Query: 419 TFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLS 478 + + G L++ + L R +E + L+ + A+ LH S Sbjct: 96 KLHYAFQTEGKLYLILDF----LRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH-S 150 Query: 479 CGYTHQDLQPQNILIDSKKAAHLADFDKSIK----------WAGDPQEV----------- 517 G ++DL+P+NIL+D + L DF S + + G + + Sbjct: 151 LGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHT 210 Query: 518 -KRDLEDLGRLVLYVVKKGSISFE--------DLKAQSNEEVVQLSPDEETKDLIHRLFH 568 D G ++++ + G++ F+ + ++ + Q E + L+ LF Sbjct: 211 QSADWWSFG-VLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQF-LSPEAQSLLRMLFK 268 Query: 569 PGEHVR-----DCLSDLLGHPFFWT--WESRYR 594 R D + ++ H FF T W YR Sbjct: 269 RNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYR 301 >5D68-A nrPDB Length = 486 Score = 114 bits (286), Expect = 1e-25, Method: Composition-based stats. Identities = 39/132 (29%), Positives = 59/132 (44%), Gaps = 12/132 (9%) Query: 95 PFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG-ANVNL 153 P +A G +LL LS+ VN+ D + A YGKV+A + L ++G N NL Sbjct: 41 PLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNL 100 Query: 154 RRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSS 213 L ++ L AA GH E+++ILL+ D + D GR+ L + Sbjct: 101 ----------LNGQLSSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNICE-EN 149 Query: 214 DDSDVEAITHLL 225 ++ E LL Sbjct: 150 KQNNWEEAAKLL 161 Score = 74.4 bits (181), Expect = 2e-13, Method: Composition-based stats. Identities = 18/105 (17%), Positives = 36/105 (34%), Gaps = 2/105 (1%) Query: 62 PLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKG-ADVNE 120 PLH + +++ LL + P A G V+ ++ L KG + N Sbjct: 41 PLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNL 100 Query: 121 CDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLR 165 + + AA G + ++ L + ++ + L Sbjct: 101 LNGQLSSPLHFAAGGGHAEIVQILLNH-PETDRHITDQQGRSPLN 144 Score = 60.5 bits (145), Expect = 3e-09, Method: Composition-based stats. Identities = 22/98 (22%), Positives = 37/98 (37%), Gaps = 8/98 (8%) Query: 20 RAAVEDNHLLIKAVQNEDVDLVQQLLEGG-ANVNFQEEEGGWTPLHNAVQMSREDIVELL 78 + + + A V+ + LLE G N N + +PLH A +IV++L Sbjct: 66 QLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNLLNGQL-SSPLHFAAGGGHAEIVQIL 124 Query: 79 LRHGA-DPVLRKKNGATPFILAAIAGSV----KLLKLF 111 L H D + + G +P + + KL Sbjct: 125 LNHPETDRHITDQQGRSPLNI-CEENKQNNWEEAAKLL 161 Score = 55.1 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 26/148 (17%), Positives = 42/148 (28%), Gaps = 7/148 (4%) Query: 209 ALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEIND 268 L S + LL VN P+ A + + LLE+ N Sbjct: 41 PLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNL 100 Query: 269 TDSDGKTALLLAVELKLKKIAELLCKR-GASTDCGDLVMTARRNYDHSLVKVLLSHGA-- 325 + + L A +I ++L D + N + A Sbjct: 101 LNGQLSSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNICEENKQNNWEEAAKL 160 Query: 326 -KEDFHPPAED---WKPQSSHWGAALKD 349 KE + P E ++ S+ LK Sbjct: 161 LKEAINKPYEKVRIYRMDGSYRSVELKH 188 >1VZO-A nrPDB Length = 355 Score = 114 bits (285), Expect = 1e-25, Method: Composition-based stats. Identities = 49/258 (18%), Positives = 92/258 (35%), Gaps = 48/258 (18%) Query: 370 KIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGH 429 KI+ G +Y K+ V+ + + + E L+ R++ LVT + + Sbjct: 75 KISGHDTGKLYAMKVLKKATIVQK-AKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETK 133 Query: 430 LFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQ 489 L + + L H + E + + + I A++ LH G ++D++ + Sbjct: 134 LHLILDYINGG---ELFTHLSQ-RERFTEHEVQIYVGEIVLALEHLH-KLGIIYRDIKLE 188 Query: 490 NILIDSKKAAHLADFDKSI-----------KWAGDPQEVKRDL--------------EDL 524 NIL+DS L DF S + G + + D+ L Sbjct: 189 NILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPDIVRGGDSGHDKAVDWWSL 248 Query: 525 GRLVLYVVKKGSISFEDLKAQSNEEVVQL------SPDEE-----TKDLIHRLFHPGEHV 573 G +++Y + G+ F ++++ + P + KDLI RL Sbjct: 249 G-VLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKK 307 Query: 574 RD-----CLSDLLGHPFF 586 R ++ H FF Sbjct: 308 RLGCGPRDADEIKEHLFF 325 >4E7W-A nrPDB Length = 394 Score = 114 bits (285), Expect = 2e-25, Method: Composition-based stats. Identities = 51/292 (17%), Positives = 95/292 (32%), Gaps = 71/292 (24%) Query: 370 KIADTSEGGIYLG-FYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRG 428 I + S G ++ E EVA+K + RE+ ++ ++ ++V G Sbjct: 47 VIGNGSFGVVFQAKLVESDEVAIKKVLQDKRFKNRELQIMRIV-KHPNVVDLKAFFYSNG 105 Query: 429 ------HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYT 482 L + + +T+ H + + + + + +++ +H S G Sbjct: 106 DKKDEVFLNLVLEYVPETVYR-ASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIH-SIGIC 163 Query: 483 HQDLQPQNILIDSK-KAAHLADFDKSIKW-AGDPQ---------------------EVKR 519 H+D++PQN+L+D L DF + AG+P Sbjct: 164 HRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIFGATNYTTNI 223 Query: 520 DLEDLGRLV--------LYVVKKG---------------------------SISFEDLKA 544 D+ G ++ L+ + G F ++ Sbjct: 224 DIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHKFPQIRP 283 Query: 545 QSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF---WTWESRY 593 +V + + DLI RL R + L HPFF T E+R Sbjct: 284 HPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDELRTGEARM 335 >3E7O-A nrPDB Length = 360 Score = 114 bits (285), Expect = 2e-25, Method: Composition-based stats. Identities = 62/379 (16%), Positives = 121/379 (31%), Gaps = 113/379 (29%) Query: 352 RIYRPMIGKLKFFIDEKYK----IADTSEGGIYLGF--YEKQEVAVKTFCEG------SP 399 + Y + F + ++Y+ I ++G + F VAVK + Sbjct: 7 QFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAK 66 Query: 400 RAQREVSCLQSSRENSHLVTFYGSESHR------GHLFVCVTLCEQTLEACLDVHRGEDV 453 RA RE+ L+ + ++++ + + +++ + L + L C +H D Sbjct: 67 RAYRELVLLKCV-NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANL--CQVIHMELD- 122 Query: 454 ENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD 513 E +L + ++ LH S G H+DL+P NI++ S + DF + + + Sbjct: 123 ----HERMSYLLYQMLCGIKHLH-SAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTN 177 Query: 514 ----PQEVKR-----------------DLEDLGRLVLYVVKKGSISF------------- 539 P V R D+ +G ++ + KGS+ F Sbjct: 178 FMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMG-ELVKGSVIFQGTDHIDQWNKVI 236 Query: 540 EDLKAQS-----------------------------NEEVVQLSPDE-------ETKDLI 563 E L S + + S E + +DL+ Sbjct: 237 EQLGTPSAEFMAALQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLL 296 Query: 564 HRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPS 623 ++ R + + L HP+ W + +I Sbjct: 297 SKMLVIDPDKRISVDEALRHPYITVWYDP------------AEAEAPPPQI---YDAQLE 341 Query: 624 EHSKSFDKWTTKINECVMK 642 E + ++W I + VM Sbjct: 342 EREHAIEEWKELIYKEVMD 360 >3LM0-A nrPDB Length = 327 Score = 114 bits (285), Expect = 2e-25, Method: Composition-based stats. Identities = 41/253 (16%), Positives = 86/253 (33%), Gaps = 42/253 (16%) Query: 373 DTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFV 432 S G Y + K+ + + E++ L+ ++ ++ + + + + Sbjct: 50 SKSTGQEYAAKFLKKR---RRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIIL 106 Query: 433 CVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNIL 492 + L + ++ +E D ++ I + V LH + H DL+PQNIL Sbjct: 107 ILEYAAGGEIFSLCLPELAEMVSENDVI--RLIKQILEGVYYLHQN-NIVHLDLKPQNIL 163 Query: 493 IDS---KKAAHLADFDKSIKWA---------GDPQEVK------------RDLEDLGRLV 528 + S + DF S K G P+ + D+ ++G ++ Sbjct: 164 LSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIG-II 222 Query: 529 LYVVKKGSISF-EDLKAQSNEEVVQL----------SPDEETKDLIHRLFHPGEHVRDCL 577 Y++ + F + ++ + Q+ S + D I L R Sbjct: 223 AYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTA 282 Query: 578 SDLLGHPFFWTWE 590 L H + W+ Sbjct: 283 EICLSHSWLQQWD 295 >3FI2-A nrPDB Length = 353 Score = 114 bits (284), Expect = 2e-25, Method: Composition-based stats. Identities = 48/327 (14%), Positives = 101/327 (30%), Gaps = 96/327 (29%) Query: 351 HRIYRPMIGKLKFFIDEKYK----IADTSEGGIYLGF--YEKQEVAVKTFCEG------S 398 ++ Y +G F + ++Y+ I ++G + + + VA+K + Sbjct: 8 NQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA 67 Query: 399 PRAQREVSCLQSSRENSHLVTFYGSESHR------GHLFVCVTLCEQTLEACLDVHRGED 452 RA RE+ L + ++++ + + +++ + L + L + + Sbjct: 68 KRAYREL-VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMEL--- 123 Query: 453 VENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAG 512 + E +L + ++ LH S G H+DL+P NI++ S + DF + Sbjct: 124 ----DHERMSYLLYQMLCGIKHLH-SAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT 178 Query: 513 ----DPQEVKR-----------------DLEDLGRL--------VLYV------------ 531 P V R D+ +G + +L+ Sbjct: 179 SFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI 238 Query: 532 --------------------VKKGSISFEDLKAQSNEEVVQLSPDEE--------TKDLI 563 + + L D E +DL+ Sbjct: 239 EQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLL 298 Query: 564 HRLFHPGEHVRDCLSDLLGHPFFWTWE 590 ++ R + D L HP+ W Sbjct: 299 SKMLVIDPAKRISVDDALQHPYINVWY 325 >4AW2-A nrPDB Length = 437 Score = 113 bits (283), Expect = 3e-25, Method: Composition-based stats. Identities = 55/288 (19%), Positives = 94/288 (32%), Gaps = 61/288 (21%) Query: 355 RPMIGKLKF--FIDEKYKIADTSEGGIY-----LGFYEKQEVAVKTFCEGSPRAQR-EVS 406 +P K+K E ++I G + + +V +R E + Sbjct: 60 KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 119 Query: 407 CLQSSRE------NSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEF 460 C + R+ + + T + + +L++ + L + + +E Sbjct: 120 CFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGG---DLLTLLSKFEDRLPEEM 176 Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKW---------- 510 AR L+ + A+ +H Y H+D++P NIL+D LADF +K Sbjct: 177 ARFYLAEMVIAIDSVHQ-LHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSV 235 Query: 511 -AGDPQEV-----------------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQ 552 G P + + D LG + Y + G F + Sbjct: 236 AVGTPDYISPEILQAMEGGKGRYGPECDWWSLGVCM-YEMLYGETPFYAESLVETYGKIM 294 Query: 553 LSP------------DEETKDLIHRLFHPGEHV--RDCLSDLLGHPFF 586 E KDLI RL EH ++ + D HPFF Sbjct: 295 NHKERFQFPTQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFF 342 >5NGU-A nrPDB Length = 381 Score = 113 bits (282), Expect = 3e-25, Method: Composition-based stats. Identities = 53/336 (15%), Positives = 106/336 (31%), Gaps = 88/336 (26%) Query: 363 FFIDEKYK----IADTSEGGIYLG--FYEKQEVAVKTFC-----EGSPRAQREVSCLQSS 411 F + +Y I + + G + K VA+K R RE+ L Sbjct: 38 FDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRF 97 Query: 412 RENSHLVTFYG-----SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLS 466 R + +++ + +++ L E L L + + L Sbjct: 98 R-HENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSN------DHICYFLY 150 Query: 467 SIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDK------------------SI 508 I + ++ +H S H+DL+P N+L+++ + DF + Sbjct: 151 QILRGLKYIH-SANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVAT 209 Query: 509 KWAGDP--------QEVKRDLEDLGRLVLYVVKK--------------------GSISFE 540 +W P D+ +G ++ ++ GS S E Sbjct: 210 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 269 Query: 541 DLK---------------AQSNEEVVQLSPDEETK--DLIHRLFHPGEHVRDCLSDLLGH 583 DL ++ +L P+ ++K DL+ ++ H R + L H Sbjct: 270 DLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAH 329 Query: 584 PFFWTWESRY-RTLRNVGNESDIKTRKSESEILRLL 618 P+ + + + D++ E L+ L Sbjct: 330 PYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKEL 365 >1BD8-A nrPDB Length = 156 Score = 112 bits (281), Expect = 4e-25, Method: Composition-based stats. Identities = 35/145 (24%), Positives = 59/145 (40%), Gaps = 11/145 (7%) Query: 12 GPTSSSGRRAAVEDNHL---------LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTP 62 G R E H ++ + + +LL+ GA+ N Q+ G +P Sbjct: 13 GDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQDTSGT-SP 71 Query: 63 LHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECD 122 +H+A + D +++L+ HGAD + GA P LA G ++ FL+ +D++ D Sbjct: 72 VHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDLHRRD 130 Query: 123 FYGFTAFMEAAVYGKVKALKFLYKR 147 G T A G + L Sbjct: 131 ARGLTPLELALQRGAQDLVDILQGH 155 Score = 82.4 bits (202), Expect = 6e-16, Method: Composition-based stats. Identities = 41/156 (26%), Positives = 65/156 (41%), Gaps = 13/156 (8%) Query: 66 AVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYG 125 A + +++ LL R P + G T + + GS + L +GA N D G Sbjct: 10 AARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQDTSG 68 Query: 126 FTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLK 185 + +AA G + LK L + GA+VN+ T GA + A ++GH V+ Sbjct: 69 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGT----------GALPIHLAVQEGHTAVVS 118 Query: 186 ILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAI 221 L E +D++ D G L AL V+ + Sbjct: 119 FLAAE--SDLHRRDARGLTPLELALQRGAQDLVDIL 152 Score = 76.3 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 37/154 (24%), Positives = 58/154 (37%), Gaps = 12/154 (7%) Query: 175 AAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNV 234 AA +G V+ ++ LL +A + G+ AL + S AI LL GA NV Sbjct: 9 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGS-----TAIALELLKQGASPNV 63 Query: 235 RGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCK 294 + G +P+ A L ++ L+E ++N D G + LAV+ + L Sbjct: 64 QDTSGTSPVHDAARTGFLDTLKVLVE-HGADVNVPDGTGALPIHLAVQEGHTAVVSFL-A 121 Query: 295 RGASTDCGDLVMTARRNYDH-----SLVKVLLSH 323 + D LV +L H Sbjct: 122 AESDLHRRDARGLTPLELALQRGAQDLVDILQGH 155 Score = 73.2 bits (178), Expect = 4e-13, Method: Composition-based stats. Identities = 41/164 (25%), Positives = 70/164 (42%), Gaps = 17/164 (10%) Query: 132 AAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEM 191 AA G V+ ++ L + + L + G TAL L++L + Sbjct: 9 AAARGDVQEVRRLL---------HRELVHPDALNRFGKTALQVMMFGSTAIALELL--KQ 57 Query: 192 GADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKH 251 GA N D G + + A + +L++HGADVNV G P+ LAV++ H Sbjct: 58 GASPNVQDTSGTSPVHDAA----RTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGH 113 Query: 252 LGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKR 295 +V L +++ D+ G T L LA++ + + ++L Sbjct: 114 TAVVSFLA--AESDLHRRDARGLTPLELALQRGAQDLVDILQGH 155 Score = 64.3 bits (155), Expect = 2e-10, Method: Composition-based stats. Identities = 24/131 (18%), Positives = 43/131 (32%), Gaps = 7/131 (5%) Query: 212 SSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDS 271 ++ DV+ + LL + GKT L + + + LL+Q N D+ Sbjct: 9 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKQ-GASPNVQDT 66 Query: 272 DGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHP 331 G + + A ++L + GA + D + V H A F Sbjct: 67 SGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLA-----VQEGHTAVVSFLA 121 Query: 332 PAEDWKPQSSH 342 D + + Sbjct: 122 AESDLHRRDAR 132 >4MYG-A nrPDB Length = 372 Score = 112 bits (280), Expect = 5e-25, Method: Composition-based stats. Identities = 47/333 (14%), Positives = 108/333 (32%), Gaps = 88/333 (26%) Query: 336 WKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYK----IADTSEGGIYLGFYE--KQEV 389 P+ SH K Y+ + K + + + Y + + G + + ++V Sbjct: 14 LVPRGSHMSLIRK--KGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKV 71 Query: 390 AVKTFCEG------SPRAQREVSCLQSSRENSHLVTFYGSESHRG------HLFVCVTLC 437 A+K + RA RE+ L+ ++ +++ + ++ + Sbjct: 72 AIKKLSRPFQSEIFAKRAYRELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFYLVMPFM 130 Query: 438 EQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKK 497 + L+ + + +E + ++ + K ++ +H S G H+DL+P N+ ++ Sbjct: 131 QTDLQKIMGM-------EFSEEKIQYLVYQMLKGLKYIH-SAGVVHRDLKPGNLAVNEDC 182 Query: 498 AAHLADFDKS------------IKWAGDPQEVKR--------DLEDLGRLVLYVVKKGSI 537 + DF + +W P+ + D+ +G ++ + G Sbjct: 183 ELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMA-EMLTGKT 241 Query: 538 SF------------------------------------EDLKAQSNEEVVQLSP--DEET 559 F + L ++ QL P + Sbjct: 242 LFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQA 301 Query: 560 KDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESR 592 DL+ ++ R + L HPFF + Sbjct: 302 ADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 334 >5AWM-A nrPDB Length = 394 Score = 112 bits (280), Expect = 6e-25, Method: Composition-based stats. Identities = 57/395 (14%), Positives = 119/395 (30%), Gaps = 113/395 (28%) Query: 336 WKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYK----IADTSEGGIYLG--FYEKQEV 389 P+ SH H+ Y +G F I +Y I ++G + +Q V Sbjct: 14 LVPRGSHRTMT-TAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNV 72 Query: 390 AVKTFCEG------SPRAQREVSCLQSSRENSHLVTFYGSESHR------GHLFVCVTLC 437 A+K + RA RE ++ + +++ + + + +++ + L Sbjct: 73 AIKKLSRPFQNVTHAKRAYREFKLMKLV-NHKNIIGLLNAFTPQRNLEEFQDVYLVMELM 131 Query: 438 EQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKK 497 + L + + D + +L + ++ LH S G H+DL+P NI++ + Sbjct: 132 DANLCQVIQMDLDHDRMS-------YLLYQMLCGIKHLH-SAGIIHRDLKPSNIVVKADC 183 Query: 498 AAHLADFDKSIKWAG----DPQEVKR-----------------DLEDLGRLVLYVVKKG- 535 + DF + P V R D+ +G ++ +++ G Sbjct: 184 TLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGV 243 Query: 536 ---------------------SISFEDLKAQSNEEVVQLSP------------------- 555 S SF + V+ P Sbjct: 244 LFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPND 303 Query: 556 --------DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKT 607 + ++L+ ++ R + + L H + W Sbjct: 304 NNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINVWY---------------DA 348 Query: 608 RKSESEILRLLQPGPSEHSKSFDKWTTKINECVMK 642 + ++ E + ++W I E VM Sbjct: 349 EEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMD 383 >5AIR-A nrPDB Length = 430 Score = 112 bits (279), Expect = 8e-25, Method: Composition-based stats. Identities = 41/248 (16%), Positives = 88/248 (35%), Gaps = 39/248 (15%) Query: 370 KIADTSEGGIYLGFY--EKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVT----FYGS 423 I + S G +Y + VA+K + RE+ ++ ++ ++V FY S Sbjct: 71 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSS 129 Query: 424 ESHRGHLFV--CVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 + +++ + +T+ + H + + + + +F+++ +H S G Sbjct: 130 GEKKDEVYLNLVLDYVPETVYR-VARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH-SFGI 187 Query: 482 THQDLQPQNILIDSKKAA-HLADFDKSIKW-AGDPQ---------------------EVK 518 H+D++PQN+L+D A L DF + + G+P Sbjct: 188 CHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS 247 Query: 519 RDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEH-VRDCL 577 D+ G + L + G F + T++ I + + Sbjct: 248 IDVWSAGCV-LAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM---NPNYTEFKF 303 Query: 578 SDLLGHPF 585 + HP+ Sbjct: 304 PQIKAHPW 311 >4BGQ-A nrPDB Length = 304 Score = 111 bits (277), Expect = 1e-24, Method: Composition-based stats. Identities = 49/286 (17%), Positives = 95/286 (33%), Gaps = 75/286 (26%) Query: 370 KIADTSEGGIYLGFYEK--QEVAVKTFC------EGSPRAQREVSCLQSSRENSHLVTFY 421 + + + G + +++ + VA+K F E RE+ L++ ++ ++V Sbjct: 19 VVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ-ENIVELK 77 Query: 422 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 + RG L++ E+ + L+ E E ++ + + KA+ H + Sbjct: 78 EAFRRRGKLYLVFEYVEKNMLELLE----EMPNGVPPEKVKSYIYQLIKAIHWCHKN-DI 132 Query: 482 THQDLQPQNILIDSKKAAHLADFDKSIKWA-----------------------GDPQEVK 518 H+D++P+N+LI L DF + + G P Sbjct: 133 VHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGAPYGKS 192 Query: 519 RDLEDLGRLV------------------LYVVKK--GSISFEDLKA-------------- 544 D+ +G ++ L+ ++K G + E +K Sbjct: 193 VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPA 252 Query: 545 ----QSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 QS E + DL+ L R L HP F Sbjct: 253 VNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 298 >1BLX-B nrPDB Length = 166 Score = 111 bits (277), Expect = 1e-24, Method: Composition-based stats. Identities = 34/145 (23%), Positives = 58/145 (40%), Gaps = 11/145 (7%) Query: 12 GPTSSSGRRAAVEDNHL---------LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTP 62 G R E H ++ + + +LL+ GA+ N Q+ G +P Sbjct: 19 GDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSPAVALELLKQGASPNVQDASGT-SP 77 Query: 63 LHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECD 122 +H+A + D +++L+ HGAD G+ P LA G ++ FL+ +D++ D Sbjct: 78 VHDAARTGFLDTLKVLVEHGADVNALDSTGSLPIHLAIREGHSSVVS-FLAPESDLHHRD 136 Query: 123 FYGFTAFMEAAVYGKVKALKFLYKR 147 G T A G + L Sbjct: 137 ASGLTPLELARQRGAQNLMDILQGH 161 Score = 83.6 bits (205), Expect = 3e-16, Method: Composition-based stats. Identities = 38/151 (25%), Positives = 60/151 (39%), Gaps = 13/151 (8%) Query: 66 AVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYG 125 A + +++ LL R P + G T + + GS + L +GA N D G Sbjct: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSPAVALELLKQGASPNVQDASG 74 Query: 126 FTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLK 185 + +AA G + LK L + GA+VN L G+ + A +GH V+ Sbjct: 75 TSPVHDAARTGFLDTLKVLVEHGADVNA----------LDSTGSLPIHLAIREGHSSVVS 124 Query: 186 ILLDEMGADVNACDNMGRNALIHALLSSDDS 216 L E +D++ D G L A + Sbjct: 125 FLAPE--SDLHHRDASGLTPLELARQRGAQN 153 Score = 75.1 bits (183), Expect = 1e-13, Method: Composition-based stats. Identities = 37/154 (24%), Positives = 62/154 (40%), Gaps = 12/154 (7%) Query: 175 AAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNV 234 AA +G V+ ++ LL +A + G+ AL + S A+ LL GA NV Sbjct: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGS-----PAVALELLKQGASPNV 69 Query: 235 RGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCK 294 + G +P+ A L ++ L+E ++N DS G + LA+ + L Sbjct: 70 QDASGTSPVHDAARTGFLDTLKVLVE-HGADVNALDSTGSLPIHLAIREGHSSVVSFLAP 128 Query: 295 RGASTDCGDLVM-----TARRNYDHSLVKVLLSH 323 + D AR+ +L+ +L H Sbjct: 129 E-SDLHHRDASGLTPLELARQRGAQNLMDILQGH 161 Score = 70.9 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 38/164 (23%), Positives = 66/164 (40%), Gaps = 17/164 (10%) Query: 132 AAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEM 191 AA G V+ ++ L + + L + G TAL + + L + Sbjct: 15 AAARGDVQEVRRLL---------HRELVHPDALNRFGKTALQ--VMMFGSPAVALELLKQ 63 Query: 192 GADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKH 251 GA N D G + + A + +L++HGADVN G P+ LA+ + H Sbjct: 64 GASPNVQDASGTSPVHDAA----RTGFLDTLKVLVEHGADVNALDSTGSLPIHLAIREGH 119 Query: 252 LGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKR 295 +V L +++ D+ G T L LA + + + ++L Sbjct: 120 SSVVSFLA--PESDLHHRDASGLTPLELARQRGAQNLMDILQGH 161 Score = 64.0 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 23/125 (18%), Positives = 43/125 (34%), Gaps = 7/125 (5%) Query: 212 SSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDS 271 ++ DV+ + LL + GKT L + + + LL+Q N D+ Sbjct: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSPAVALELLKQ-GASPNVQDA 72 Query: 272 DGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHP 331 G + + A ++L + GA + D + + + H + F Sbjct: 73 SGTSPVHDAARTGFLDTLKVLVEHGADVNALDSTGSLPIHLA-----IREGHSSVVSFLA 127 Query: 332 PAEDW 336 P D Sbjct: 128 PESDL 132 >2Z7Q-A nrPDB Length = 321 Score = 110 bits (276), Expect = 2e-24, Method: Composition-based stats. Identities = 50/262 (19%), Positives = 92/262 (35%), Gaps = 48/262 (18%) Query: 370 KIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGH 429 K+ G +Y K+ A + R + E L + +V + + G Sbjct: 49 KVTRPDSGHLYAMKVLKK--ATLKVRDRV-RTKMERDILADV-NHPFVVKLHYAFQTEGK 104 Query: 430 LFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQ 489 L++ + L R +E + L+ + + LH S G ++DL+P+ Sbjct: 105 LYLILDF----LRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLH-SLGIIYRDLKPE 159 Query: 490 NILIDSKKAAHLADFDKSIK----------WAGDPQEV------------KRDLEDLGRL 527 NIL+D + L DF S + + G + + D G + Sbjct: 160 NILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYG-V 218 Query: 528 VLYVVKKGSISFE--------DLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVR----- 574 +++ + GS+ F+ L ++ + Q E + L+ LF R Sbjct: 219 LMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQF-LSTEAQSLLRALFKRNPANRLGSGP 277 Query: 575 DCLSDLLGHPFFWT--WESRYR 594 D ++ H F+ T W YR Sbjct: 278 DGAEEIKRHVFYSTIDWNKLYR 299 >5FET-A nrPDB Length = 847 Score = 110 bits (275), Expect = 2e-24, Method: Composition-based stats. Identities = 48/269 (17%), Positives = 91/269 (33%), Gaps = 49/269 (18%) Query: 360 KLKFFIDEKYKIADTSEGGIYLGFYEKQEV--AVKTFCE---GSPRAQREVSCLQSS--- 411 ++ E+ I + G + L ++ ++ A+K + S Q + + Sbjct: 531 EMHELETERI-IGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAE 589 Query: 412 RENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 471 ++ ++ + + L D R + ++ A+ L SI A Sbjct: 590 NDHPFIIRLVRTFKDSNCFYFLTELVTGG--ELYDAIRKLGLLSKPQ--AQFYLGSIILA 645 Query: 472 VQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK-------WAGDPQEVK------ 518 ++ LH ++DL+P+NIL+D + L DF + K G P + Sbjct: 646 IEYLHE-RNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTLVGTPHYMAPEVILG 704 Query: 519 ------RDLEDLGRLVLYVVKKGSISFEDLKAQSNE----------EVVQLSPDEETKDL 562 D+ LG LY G + F + + E D+++ +L Sbjct: 705 KGYGCTVDIWALGVC-LYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVSDQDSINL 763 Query: 563 IHRLFHPGEHVRD-----CLSDLLGHPFF 586 + RL R D+ H FF Sbjct: 764 MKRLLCRLPQGRIGCSINGFKDIKEHAFF 792 >3OHT-A nrPDB Length = 389 Score = 110 bits (275), Expect = 2e-24, Method: Composition-based stats. Identities = 44/320 (13%), Positives = 101/320 (31%), Gaps = 83/320 (25%) Query: 348 KDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEV------AVKTFCEG---- 397 K+ YR + K + + E+Y+ G Y +V AVK Sbjct: 32 KERPTFYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSI 91 Query: 398 --SPRAQREVSCLQSSRENSHLVTFYGSE------SHRGHLFVCVTLCEQTLEACLDVHR 449 + R RE+ L+ ++ +++ +++ L L ++ + Sbjct: 92 IHAKRTYRELRLLKHM-KHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLN---NIVK 147 Query: 450 GEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDK--- 506 + + D+ + ++ I + ++ +H S H+DL+P N+ ++ + DF Sbjct: 148 CQKLT---DDHVQFLIYQILRGLKYIH-SADIIHRDLKPSNLAVNEDCELKILDFGLARH 203 Query: 507 ---------SIKWAGDP--------QEVKRDLEDLGRLVLYVV----------------- 532 + +W P + D+ +G ++ ++ Sbjct: 204 TDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQ 263 Query: 533 ---KKGSISFEDLKA-----------------QSNEEVVQLSPDEETKDLIHRLFHPGEH 572 G+ + + N V + + DL+ ++ Sbjct: 264 IMRLTGTPPASVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTD 323 Query: 573 VRDCLSDLLGHPFFWTWESR 592 R S+ L HP+F + Sbjct: 324 KRITASEALAHPYFSQYHDP 343 >5DYK-A nrPDB Length = 853 Score = 110 bits (274), Expect = 3e-24, Method: Composition-based stats. Identities = 51/269 (18%), Positives = 96/269 (35%), Gaps = 49/269 (18%) Query: 360 KLKFFIDEKYKIADTSEGGIYLGFYEKQEV--AVKTFCEGSP---RAQREVSCLQSS--- 411 ++ E+ I + G + L ++ ++ A+K + S Q + + Sbjct: 537 EMDELETERI-IGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAE 595 Query: 412 RENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 471 ++ ++ + + + L D R + ++ A+ L SI A Sbjct: 596 NDHPFIIRLVRTFKDSKYFYFLTELVTGG--ELYDAIRKLGLLSKSQ--AQFYLGSIILA 651 Query: 472 VQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWA-------GDPQEVK------ 518 ++ LH ++DL+P+NIL+D + L DF + K G P + Sbjct: 652 IEYLHE-RNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILG 710 Query: 519 ------RDLEDLGRLVLYVVKKGSISF-----EDLKAQSNEEVVQLS-----PDEETKDL 562 D+ LG LY G + F + L+ + QL+ D ++ +L Sbjct: 711 KGYGCTVDIWALGIC-LYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVTDTDSINL 769 Query: 563 IHRLFHPGEHVRD-----CLSDLLGHPFF 586 + RL R D+ HPFF Sbjct: 770 MKRLLCRLPQGRIGCSINGFKDIKDHPFF 798 >3E3P-A nrPDB Length = 360 Score = 110 bits (274), Expect = 3e-24, Method: Composition-based stats. Identities = 50/341 (14%), Positives = 102/341 (29%), Gaps = 93/341 (27%) Query: 367 EKYKIADTSEGGIYLGFYEKQE------VAVKTFCEGSPRAQREVSCLQS--SRENSHLV 418 +++++ + G + +E VA+K + RE+ +Q + ++V Sbjct: 23 DRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNRELQIMQDLAVLHHPNIV 82 Query: 419 TFYGSES-----HRGHLF--VCVTLCEQTL-EACLDVHRGEDVENEEDEFARNVLSSIFK 470 R ++ V + TL C + +R + + L + + Sbjct: 83 QLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPP--ILIKVFLFQLIR 140 Query: 471 AVQELHL-SCGYTHQDLQPQNILIDS-KKAAHLADFDKSIKWA----------------- 511 ++ LHL S H+D++P N+L++ L DF + K + Sbjct: 141 SIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRYYRAP 200 Query: 512 ----GDPQEVKR-DLEDLGRLVLYVVKKGSISFE-------------------------- 540 G+ D+ +G + + G F Sbjct: 201 ELIFGNQHYTTAVDIWSVGCIFA-EMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVLRKL 259 Query: 541 -------DLKAQSNEEVV------QLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFW 587 DL L +E DL+ L R + L HP+F Sbjct: 260 NPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEALCHPYFD 319 Query: 588 TWESRY-----------RTLRNVGNESDIKTRKSESEILRL 617 R + NE ++ + +++++R Sbjct: 320 ELHDPATKLPNNKDLPEDLFRFLPNEIEVMSEAQKAKLVRK 360 >4C59-A nrPDB Length = 340 Score = 109 bits (273), Expect = 4e-24, Method: Composition-based stats. Identities = 51/326 (15%), Positives = 105/326 (32%), Gaps = 79/326 (24%) Query: 358 IGKLKFFIDEKYKIADTSEGGIYLGFYEKQEV------AVKTFC----EGSPRAQREVSC 407 +G+ + + ++ G + YE Q+V A+K E + +EV Sbjct: 18 VGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCF 77 Query: 408 LQSSRENSHLVTF-----YGSESHRG---HLFVCVTLCEQTLEACLDVHRGEDVENEEDE 459 ++ + ++V F G E + LC+ L L + E + Sbjct: 78 MKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLK--KMESRGPLSCD 135 Query: 460 FARNVLSSIFKAVQELHLSCG-YTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV- 517 + +AVQ +H H+DL+ +N+L+ ++ L DF + + P Sbjct: 136 TVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSW 195 Query: 518 ------------------------------------KRDLEDLGRLVLYVVKKGSISFED 541 K+D+ LG +LY++ FED Sbjct: 196 SAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGC-ILYLLCFRQHPFED 254 Query: 542 ---LKAQSNEEVVQLSPDE--ETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTL 596 L+ + + + + LI + R +++++ L Sbjct: 255 GAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQ------------L 302 Query: 597 RNVGNESDIKTRKSESEILRLLQPGP 622 + + ++ +S I LL+ Sbjct: 303 QEIAAARNV---NPKSPITELLEQNG 325 >2XS0-A nrPDB Length = 386 Score = 109 bits (272), Expect = 5e-24, Method: Composition-based stats. Identities = 52/372 (13%), Positives = 111/372 (29%), Gaps = 111/372 (29%) Query: 358 IGKLKFFIDEKYK----IADTSEGGIYLGF--YEKQEVAVKTFCEG------SPRAQREV 405 IG F + ++Y+ I ++G + + ++ VA+K + RA RE+ Sbjct: 17 IGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYREL 76 Query: 406 SCLQSSRENSHLVTFYGSESHR------GHLFVCVTLCEQTLEACLDVHRGEDVENEEDE 459 L + +++ + + +++ + L + L + + + E Sbjct: 77 -VLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMEL-------DHE 128 Query: 460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWA-------- 511 +L + ++ LH S G H+DL+P NI++ S + DF + Sbjct: 129 RMSYLLYQMLCGIKHLH-SAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPF 187 Query: 512 -------------GDPQEVKRDLEDLGRLVLYVVKKG----------------------- 535 G + D+ +G ++ ++K G Sbjct: 188 VVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPC 247 Query: 536 -----------------SISFEDLKAQSNEEVVQLSPDEE--------TKDLIHRLFHPG 570 + + V D E +DL+ ++ Sbjct: 248 PEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVID 307 Query: 571 EHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFD 630 R + + L HP+ W + +I E + + Sbjct: 308 ASKRISVDEALQHPYINVWYDPS------------EAEAPPPKIP---DKQLDEREHTIE 352 Query: 631 KWTTKINECVMK 642 +W I + VM Sbjct: 353 EWKELIYKEVMD 364 >3GC0-A nrPDB Length = 329 Score = 108 bits (269), Expect = 1e-23, Method: Composition-based stats. Identities = 47/289 (16%), Positives = 83/289 (28%), Gaps = 79/289 (27%) Query: 370 KIADTSEGGIYLGF--YEKQEVAVKTFC-----EGSP-RAQREVSCLQSSRENSHLVTFY 421 K+ + + G +Y + VA+K EG P A REVS L+ ++ +++ Sbjct: 41 KLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKEL-QHRNIIELK 99 Query: 422 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 H L + E L+ +D + ++ L + V H S Sbjct: 100 SVIHHNHRLHLIFEYAENDLKKYMD-----KNPDVSMRVIKSFLYQLINGVNFCH-SRRC 153 Query: 482 THQDLQPQNILIDSKKA-----AHLADFDKSIK-----------------------WAGD 513 H+DL+PQN+L+ A + DF + Sbjct: 154 LHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEILLGSR 213 Query: 514 PQEVKRDLEDLGRLVLYVVKK-----GSISFEDL----------------KAQSNEEVVQ 552 D+ + + ++ K G + L + + Q Sbjct: 214 HYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTALPDWKQ 273 Query: 553 LSPDEETKDLIH---------------RLFHPGEHVRDCLSDLLGHPFF 586 P K L + R + L HP+F Sbjct: 274 SFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYF 322 >5AP3-A nrPDB Length = 313 Score = 108 bits (269), Expect = 1e-23, Method: Composition-based stats. Identities = 49/275 (17%), Positives = 96/275 (34%), Gaps = 65/275 (23%) Query: 369 YKIADTSEGGIYLGFY-----EKQEVAVKTFC------EGSPRAQREVSCLQSSRENSH- 416 Y I G + +KQ A+K + + E++ L +++S Sbjct: 30 YSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDK 89 Query: 417 LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 ++ Y E ++++ + L L + D E + +N+L +AV +H Sbjct: 90 IIRLYDYEITDQYIYMVMECGNIDLNGWLKKKKSID-PWERKSYWKNML----EAVHTIH 144 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD-----------------PQEVK- 518 G H DL+P N LI L DF + + D P+ +K Sbjct: 145 Q-HGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKD 202 Query: 519 -----------------RDLEDLGRLVLYVVKKGSISFEDLKAQSNE--------EVVQL 553 D+ LG ++ Y + G F+ + Q ++ ++ Sbjct: 203 MSSSRENGKSKSKISPKSDVWSLGCILYY-MTYGKTPFQQIINQISKLHAIIDPNHEIEF 261 Query: 554 S--PDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 P+++ +D++ R + +LL HP+ Sbjct: 262 PDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYV 296 >1UA2-A nrPDB Length = 346 Score = 107 bits (268), Expect = 1e-23, Method: Composition-based stats. Identities = 50/292 (17%), Positives = 91/292 (31%), Gaps = 80/292 (27%) Query: 368 KYKIADTSEGGIYLGFYEKQE------VAVKTFCEGSPR---------AQREVSCLQSSR 412 +Y+ D G + Y+ ++ VA+K G A RE+ LQ Sbjct: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 Query: 413 ENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAV 472 + +++ + H+ ++ + E LE V ++ + + + + Sbjct: 71 -HPNIIGLLDAFGHKSNISLVFDFMETDLE----VIIKDNSLVLTPSHIKAYMLMTLQGL 125 Query: 473 QELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE---------------- 516 + LH H+DL+P N+L+D LADF + + G P Sbjct: 126 EYLHQ-HWILHRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTHQVVTRWYRAPEL 183 Query: 517 --------VKRDLEDLGRLVLYVVK-KGSIS-----------FEDLKAQSNEEVVQ---L 553 V D+ +G ++ ++ + FE L + E+ L Sbjct: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 Query: 554 SPDEETK-------------------DLIHRLFHPGEHVRDCLSDLLGHPFF 586 K DLI LF R + L +F Sbjct: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 >6GVJ-A nrPDB Length = 429 Score = 107 bits (268), Expect = 1e-23, Method: Composition-based stats. Identities = 49/275 (17%), Positives = 97/275 (35%), Gaps = 65/275 (23%) Query: 369 YKIADTSEGGIYLGFY-----EKQEVAVKTFC------EGSPRAQREVSCLQSSRENSH- 416 Y I G + +KQ A+K + + E++ L +++S Sbjct: 146 YSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDK 205 Query: 417 LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 ++ Y E ++++ + L + L + D E + +N+L +AV +H Sbjct: 206 IIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSID-PWERKSYWKNML----EAVHTIH 260 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD-----------------PQEVK- 518 G H DL+P N LI L DF + + D P+ +K Sbjct: 261 Q-HGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKD 318 Query: 519 -----------------RDLEDLGRLVLYVVKKGSISFEDLKAQSNE--------EVVQL 553 D+ LG ++ Y + G F+ + Q ++ ++ Sbjct: 319 MSSSRENGKSKSKISPKSDVWSLGCILYY-MTYGKTPFQQIINQISKLHAIIDPNHEIEF 377 Query: 554 S--PDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 P+++ +D++ R + +LL HP+ Sbjct: 378 PDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYV 412 >3PG1-A nrPDB Length = 362 Score = 107 bits (267), Expect = 2e-23, Method: Composition-based stats. Identities = 50/313 (15%), Positives = 82/313 (26%), Gaps = 87/313 (27%) Query: 371 IADTSEGGIYLGF-YEKQEVAVKTFCEG---------------SPRAQREVSCLQSSREN 414 I+ S G + G E VA+K R RE+ L + Sbjct: 30 ISSGSYGAVCAGVDSEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRLLNHFH-H 88 Query: 415 SHLVTFYGSESH-----RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIF 469 +++ H L++ L L V + + + + I Sbjct: 89 PNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQ---VIHDQRIVISPQHI-QYFMYHIL 144 Query: 470 KAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE------------- 516 + LH + G H+DL P NIL+ + DF+ + + D + Sbjct: 145 LGLHVLHEA-GVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYRAPE 203 Query: 517 ---------VKRDLEDLGRLV--------------LY-----------------VVKKGS 536 D+ G ++ Y VV S Sbjct: 204 LVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMFSS 263 Query: 537 ISFEDLKAQSNEEVVQL-------SPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTW 589 S D S V + D DLI ++ R L HP+F + Sbjct: 264 PSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYFESL 323 Query: 590 ESRYRTLRNVGNE 602 + Sbjct: 324 FDPLDLTEGLSER 336 >2W96-B nrPDB Length = 306 Score = 107 bits (267), Expect = 2e-23, Method: Composition-based stats. Identities = 50/286 (17%), Positives = 88/286 (30%), Gaps = 73/286 (25%) Query: 370 KIADTSEGGIYLGF--YEKQEVAVKTFC-----EGSP-RAQREVSCLQSSR--ENSHLVT 419 +I + G +Y + VA+K+ EG P REV+ L+ E+ ++V Sbjct: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEHPNVVR 70 Query: 420 FYGSESHRG-----HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 + + + +Q L LD + E ++++ + + Sbjct: 71 LMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAET---IKDLMRQFLRGLDF 127 Query: 475 LHLSCGYTHQDLQPQNILIDSKKAAHLADFDK----SIKWAGDP---------------- 514 LH +C H+DL+P+NIL+ S LADF S + A DP Sbjct: 128 LHANC-IVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEVLLQS 186 Query: 515 -QEVKRDLEDLGRLVLYVV--------------------KKGSISFEDLKAQSNEEVVQL 553 D+ +G + + G +D + Sbjct: 187 TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAF 246 Query: 554 SP-------------DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 P +E L+ + H R L H + Sbjct: 247 PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 292 >4CSV-A nrPDB Length = 275 Score = 107 bits (266), Expect = 2e-23, Method: Composition-based stats. Identities = 47/250 (18%), Positives = 91/250 (36%), Gaps = 44/250 (17%) Query: 370 KIADTSEGGIYLGFYEKQ--EVAVKTFCEGSPRAQ---REVSCLQSSRENSHLVTFYGSE 424 K+ G +Y G + EVAVKT EG+ + +E ++ ++ +LV YG Sbjct: 18 KLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQIMKKL-KHPNLVQLYGVC 76 Query: 425 SHRGHLFVCVTLC-EQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTH 483 + +++ +L L G V + ++ + + + L S + H Sbjct: 77 TKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALL---DMAAQVASGMAYL-ESQNFIH 132 Query: 484 QDLQPQNILIDSKKAAHLADFDKS-----------------IKWAG------DPQEVKRD 520 +DL +N L+ +ADF + IKW + +K D Sbjct: 133 RDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAPEAISYNRFSIKSD 192 Query: 521 LEDLGRLVLYVVKKGSISF---------EDLKAQSNEEVVQLSPDEETKDLIHRLFHPGE 571 + G L+ + G + + E ++ Q P EE +L+ + ++ Sbjct: 193 VWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCP-EEIYELMLQCWNKSP 251 Query: 572 HVRDCLSDLL 581 R ++ L Sbjct: 252 EERPTFAETL 261 >4EBW-A nrPDB Length = 304 Score = 107 bits (266), Expect = 3e-23, Method: Composition-based stats. Identities = 44/251 (17%), Positives = 84/251 (33%), Gaps = 47/251 (18%) Query: 371 IADTSEGGIYLGFYEKQE-----VAVKTFCEGSPRAQREV----SCLQSSRENSHLVTFY 421 I + G ++ G Y E VA+KT + + RE + ++ H+V Sbjct: 46 IGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLI 105 Query: 422 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 G +++ + LC R ++ + A+ L S + Sbjct: 106 GV-ITENPVWIIMELCTLGELRSFLQVRKYSLDLASLIL---YAYQLSTALAYL-ESKRF 160 Query: 482 THQDLQPQNILIDSKKAAHLADFDKS-----------------IKWAGDPQEV------- 517 H+D+ +N+L+ S L DF S IKW P+ + Sbjct: 161 VHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMA-PESINFRRFTS 219 Query: 518 KRDLEDLGRLVLYVVKKGSISFEDLK------AQSNEEVVQLSPD--EETKDLIHRLFHP 569 D+ G + ++ G F+ +K N E + + P+ L+ + + Sbjct: 220 ASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAY 279 Query: 570 GEHVRDCLSDL 580 R ++L Sbjct: 280 DPSRRPRFTEL 290 >3HMP-A nrPDB Length = 342 Score = 106 bits (265), Expect = 3e-23, Method: Composition-based stats. Identities = 49/275 (17%), Positives = 97/275 (35%), Gaps = 65/275 (23%) Query: 369 YKIADTSEGGIYLGFY-----EKQEVAVKTFC------EGSPRAQREVSCLQSSRENSH- 416 Y I G + +KQ A+K + + E++ L +++S Sbjct: 58 YSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDK 117 Query: 417 LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 ++ Y E ++++ + L + L + D E + +N+L +AV +H Sbjct: 118 IIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSID-PWERKSYWKNML----EAVHTIH 172 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD-----------------PQEVK- 518 G H DL+P N LI L DF + + D P+ +K Sbjct: 173 Q-HGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKD 230 Query: 519 -----------------RDLEDLGRLVLYVVKKGSISFEDLKAQSNE--------EVVQL 553 D+ LG ++ Y + G F+ + Q ++ ++ Sbjct: 231 MSSSRENGKSKSKISPKSDVWSLGCILYY-MTYGKTPFQQIINQISKLHAIIDPNHEIEF 289 Query: 554 S--PDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 P+++ +D++ R + +LL HP+ Sbjct: 290 PDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYV 324 >2A1A-B nrPDB Length = 284 Score = 106 bits (264), Expect = 4e-23, Method: Composition-based stats. Identities = 52/262 (19%), Positives = 98/262 (37%), Gaps = 47/262 (17%) Query: 371 IADTSEGGIYLGFY--EKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTF-------- 420 I G ++ + + + +K + +A+REV L ++ ++V + Sbjct: 19 IGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKL-DHVNIVHYNGCWDGFD 77 Query: 421 YGSESHRG--------HLFVCVTLCE-QTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 471 Y E+ LF+ + C+ TLE ++ RGE ++ A + I K Sbjct: 78 YDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLD---KVLALELFEQITKG 134 Query: 472 VQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD--------------PQEV 517 V +H S ++DL+P NI + K + DF D P+++ Sbjct: 135 VDYIH-SKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQI 193 Query: 518 KR-------DLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSP--DEETKDLIHRLFH 568 DL LG ++ ++ +FE K ++ +S D++ K L+ +L Sbjct: 194 SSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLS 253 Query: 569 PGEHVRDCLSDLLGHPFFWTWE 590 R S++L W Sbjct: 254 KKPEDRPNTSEILRTLTVWKKS 275 >2ZMD-A nrPDB Length = 390 Score = 105 bits (263), Expect = 5e-23, Method: Composition-based stats. Identities = 49/275 (17%), Positives = 97/275 (35%), Gaps = 65/275 (23%) Query: 369 YKIADTSEGGIYLGFY-----EKQEVAVKTFC------EGSPRAQREVSCLQSSRENSH- 416 Y I G + +KQ A+K + + E++ L +++S Sbjct: 58 YSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDK 117 Query: 417 LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 ++ Y E ++++ + L + L + D E + +N+L +AV +H Sbjct: 118 IIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSID-PWERKSYWKNML----EAVHTIH 172 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD-----------------PQEVK- 518 G H DL+P N LI L DF + + D P+ +K Sbjct: 173 Q-HGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKD 230 Query: 519 -----------------RDLEDLGRLVLYVVKKGSISFEDLKAQSNE--------EVVQL 553 D+ LG ++ Y + G F+ + Q ++ ++ Sbjct: 231 MSSSRENGKSKSKISPKSDVWSLGCILYY-MTYGKTPFQQIINQISKLHAIIDPNHEIEF 289 Query: 554 S--PDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 P+++ +D++ R + +LL HP+ Sbjct: 290 PDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYV 324 >3PPZ-A nrPDB Length = 309 Score = 105 bits (263), Expect = 5e-23, Method: Composition-based stats. Identities = 44/253 (17%), Positives = 93/253 (36%), Gaps = 41/253 (16%) Query: 368 KYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQR------EVSCLQSSRENSHLVTFY 421 K KI S G ++ + +VAVK E A+R EV+ ++ R + ++V F Sbjct: 42 KEKIGAGSFGTVHRAEWHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLR-HPNIVLFM 100 Query: 422 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH-LSCG 480 G+ + +L + + +H+ E ++ ++ + K + LH + Sbjct: 101 GAVTQPPNLSIVTEYLSRG-SLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPP 159 Query: 481 YTHQDLQPQNILIDSKKAAHLADFDK----------SIKWAGDPQEV------------K 518 H+DL+ N+L+D K + DF S AG P+ + K Sbjct: 160 IVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEK 219 Query: 519 RDLEDLGRLVLYVVKKGSISFEDLK---------AQSNEEVVQLSPDEETKDLIHRLFHP 569 D+ G ++L+ + + +L + + + + + +I + Sbjct: 220 SDVYSFG-VILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEGCWTN 278 Query: 570 GEHVRDCLSDLLG 582 R + ++ Sbjct: 279 EPWKRPSFATIMD 291 >3C51-A nrPDB Length = 543 Score = 105 bits (263), Expect = 6e-23, Method: Composition-based stats. Identities = 38/208 (18%), Positives = 70/208 (33%), Gaps = 40/208 (19%) Query: 417 LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 +V+ + + L + +T+ + ED ++ A + I ++ LH Sbjct: 247 IVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLH 306 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKW----------AGDP------------ 514 ++DL+P+N+L+D ++D +++ AG P Sbjct: 307 Q-RNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEE 365 Query: 515 QEVKRDLEDLGRLVLYVVKKGSISF---------EDLKAQSNEEVVQLSP--DEETKDLI 563 + D LG + LY + F ++LK + E+ V +KD Sbjct: 366 YDFSVDYFALG-VTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFC 424 Query: 564 HRLFHPGEHVRDCLSD-----LLGHPFF 586 L R D L HP F Sbjct: 425 EALLQKDPEKRLGFRDGSCDGLRTHPLF 452 >3T9K-A nrPDB Length = 390 Score = 105 bits (262), Expect = 8e-23, Method: Composition-based stats. Identities = 43/143 (30%), Positives = 64/143 (44%), Gaps = 6/143 (4%) Query: 152 NLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEM--GADVNACDNMGRNALIHA 209 +LR K + E L AL+ A GH L + D + GADVN + NA Sbjct: 182 DLRSKPEPPSEDLGSLHPGALLFRA-SGHPPSLPTMADALAHGADVNWVNGGQDNAT--P 238 Query: 210 LLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDT 269 L+ + ++ LL +GA+VN G+ PL A H GL L++ ++ Sbjct: 239 LIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKR-GADLGAR 297 Query: 270 DSDGKTALLLAVELKLKKIAELL 292 DS+G+ L +A+E I LL Sbjct: 298 DSEGRDPLTIAMETANADIVTLL 320 Score = 94.8 bits (234), Expect = 1e-19, Method: Composition-based stats. Identities = 35/130 (26%), Positives = 50/130 (38%), Gaps = 13/130 (10%) Query: 79 LRHGADPV--LRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYG 136 L HGAD ++ ATP I A A S+ + L GA+VN+ D G A + G Sbjct: 220 LAHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILG 279 Query: 137 KVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKIL-LDEMGADV 195 KRGA++ R D L A E + +++ +L L +M Sbjct: 280 HTGLACLFLKRGADLGARDSEGRD----------PLTIAMETANADIVTLLRLAKMREAE 329 Query: 196 NACDNMGRNA 205 A G Sbjct: 330 AAQGQAGDET 339 Score = 84.8 bits (208), Expect = 1e-16, Method: Composition-based stats. Identities = 37/142 (26%), Positives = 53/142 (37%), Gaps = 5/142 (3%) Query: 5 DHNNPQEGPTSSSGRRAAVEDNHLLIKAV-QNEDVDLVQQLLEGGANVN-FQEEEGGWTP 62 D + E P+ G ++ LL +A + + L GA+VN + TP Sbjct: 182 DLRSKPEPPSEDLG---SLHPGALLFRASGHPPSLPTMADALAHGADVNWVNGGQDNATP 238 Query: 63 LHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECD 122 L A + E LL++GA+ G P A I G L LFL +GAD+ D Sbjct: 239 LIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGADLGARD 298 Query: 123 FYGFTAFMEAAVYGKVKALKFL 144 G A + L Sbjct: 299 SEGRDPLTIAMETANADIVTLL 320 Score = 37.0 bits (84), Expect = 0.031, Method: Composition-based stats. Identities = 14/72 (19%), Positives = 24/72 (33%), Gaps = 7/72 (9%) Query: 262 EHIEINDTD--SDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVK- 318 ++N + D T L+ A E L + GA+ + D ++ L Sbjct: 222 HGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHT 281 Query: 319 ----VLLSHGAK 326 + L GA Sbjct: 282 GLACLFLKRGAD 293 >2J0K-A nrPDB Length = 656 Score = 105 bits (261), Expect = 8e-23, Method: Composition-based stats. Identities = 44/265 (16%), Positives = 87/265 (32%), Gaps = 47/265 (17%) Query: 371 IADTSEGGIYLGFYEKQE-----VAVKTFCEGSPRAQREV----SCLQSSRENSHLVTFY 421 I + G ++ G Y E VA+KT + + RE + ++ H+V Sbjct: 398 IGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLI 457 Query: 422 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 G +++ + LC R ++ + A+ L S + Sbjct: 458 GV-ITENPVWIIMELCTLGELRSFLQVRKFSLDLASLIL---YAYQLSTALAYL-ESKRF 512 Query: 482 THQDLQPQNILIDSKKAAHLADFDKS-----------------IKWAGDPQEV------- 517 H+D+ +N+L+ + L DF S IKW P+ + Sbjct: 513 VHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMA-PESINFRRFTS 571 Query: 518 KRDLEDLGRLVLYVVKKGSISFEDLK------AQSNEEVVQLSPD--EETKDLIHRLFHP 569 D+ G + ++ G F+ +K N E + + P+ L+ + + Sbjct: 572 ASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAY 631 Query: 570 GEHVRDCLSDLLGHPFFWTWESRYR 594 R ++L E + + Sbjct: 632 DPSRRPRFTELKAQLSTILEEEKLQ 656 >3UIU-A nrPDB Length = 306 Score = 105 bits (261), Expect = 8e-23, Method: Composition-based stats. Identities = 52/275 (18%), Positives = 98/275 (35%), Gaps = 60/275 (21%) Query: 371 IADTSEGGIYLGFY--EKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTF-------- 420 I G ++ + + + ++ + +A+REV L ++ ++V + Sbjct: 20 IGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEKAEREVKALAKL-DHVNIVHYNGCWDGFD 78 Query: 421 YGSESHRG---------------------HLFVCVTLCE-QTLEACLDVHRGEDVENEED 458 Y E+ LF+ + C+ TLE ++ RGE ++ Sbjct: 79 YDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLD---K 135 Query: 459 EFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD----- 513 A + I K V +H S H+DL+P NI + K + DF D Sbjct: 136 VLALELFEQITKGVDYIH-SKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTR 194 Query: 514 ---------PQEVKR-------DLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSP-- 555 P+++ DL LG ++ ++ +FE K ++ +S Sbjct: 195 SKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIF 254 Query: 556 DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWE 590 D++ K L+ +L R S++L W Sbjct: 255 DKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKS 289 >4EWQ-A nrPDB Length = 383 Score = 105 bits (261), Expect = 1e-22, Method: Composition-based stats. Identities = 46/327 (14%), Positives = 105/327 (32%), Gaps = 85/327 (25%) Query: 342 HWGAALKDLHRIYRPMIGKLKFFIDEKYK----IADTSEGGIYLGFYEKQE--VAVKTFC 395 A ++ YR + K + + E+Y+ + + G + F K VAVK Sbjct: 20 FQSNASQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLS 79 Query: 396 EG------SPRAQREVSCLQSSRENSHLVTFYGSE------SHRGHLFVCVTLCEQTLEA 443 + R RE+ L+ ++ +++ +++ L L Sbjct: 80 RPFQSIIHAKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLN- 137 Query: 444 CLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLAD 503 ++ + + + D+ + ++ I + ++ +H S H+DL+P N+ ++ + D Sbjct: 138 --NIVKCQKLT---DDHVQFLIYQILRGLKYIH-SADIIHRDLKPSNLAVNEDCELKILD 191 Query: 504 FDK------------SIKWAGDPQEV--------KRDLEDLGRLVLYVVKKGSISF---- 539 F + +W P+ + D+ +G ++ + G F Sbjct: 192 FGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMA-ELLTGRTLFPGTD 250 Query: 540 --EDLKA--------------------------------QSNEEVVQLSPDEETKDLIHR 565 + LK + N V + + DL+ + Sbjct: 251 HIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEK 310 Query: 566 LFHPGEHVRDCLSDLLGHPFFWTWESR 592 + R + L H +F + Sbjct: 311 MLVLDSDKRITAAQALAHAYFAQYHDP 337 >4GS6-A nrPDB Length = 315 Score = 105 bits (261), Expect = 1e-22, Method: Composition-based stats. Identities = 42/245 (17%), Positives = 81/245 (33%), Gaps = 35/245 (14%) Query: 370 KIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSR-ENSHLVTFYGSESHRG 428 + + G + + ++VA+K S R V Q SR + ++V YG+ + Sbjct: 16 VVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPV 75 Query: 429 HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSC--GYTHQDL 486 L + E +H E + A + + V LH H+DL Sbjct: 76 CL--VMEYAEGG-SLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDL 132 Query: 487 QPQNILIDSKKAA-HLADFDKSIKWA-------------------GDPQEVKRDLEDLGR 526 +P N+L+ + + DF + G K D+ G Sbjct: 133 KPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGI 192 Query: 527 LVLYVVK-------KGSISFEDLKAQSNEEVVQLSPD--EETKDLIHRLFHPGEHVRDCL 577 ++ V+ G +F + A N L + + + L+ R + R + Sbjct: 193 ILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSM 252 Query: 578 SDLLG 582 +++ Sbjct: 253 EEIVK 257 >5VD3-A nrPDB Length = 311 Score = 104 bits (260), Expect = 1e-22, Method: Composition-based stats. Identities = 44/248 (17%), Positives = 82/248 (33%), Gaps = 38/248 (15%) Query: 370 KIADTSEGGIYL--GFYEKQEVAVKTF------CEGSPRAQREVSCLQSSRENSHLVTFY 421 ++ S G ++ + + AVK + R EV + ++ V Sbjct: 64 RLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLE 123 Query: 422 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 + G L++ LC +L+ + + + L A+ LH S G Sbjct: 124 QAWEEGGILYLQTELCGPSLQQHCEAWG----ASLPEAQVWGYLRDTLLALAHLH-SQGL 178 Query: 482 THQDLQPQNILIDSKKAAHLADFDKSIKWA---------GDPQEV-----------KRDL 521 H D++P NI + + L DF ++ GDP+ + D+ Sbjct: 179 VHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADV 238 Query: 522 EDLGRLVLYV-----VKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDC 576 LG +L V + G ++ L+ E + ++ + P +R Sbjct: 239 FSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRAT 298 Query: 577 LSDLLGHP 584 LL P Sbjct: 299 AEALLALP 306 >5O2C-A nrPDB Length = 380 Score = 104 bits (260), Expect = 1e-22, Method: Composition-based stats. Identities = 62/365 (16%), Positives = 114/365 (31%), Gaps = 68/365 (18%) Query: 368 KYKIADTSEGGIYLGFYEKQEVAV--------KTFCEGSPRAQREVSCLQSSRENSHLVT 419 ++ + +Y G + V V K R + E L+ ++ ++V Sbjct: 30 DIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLK-GLQHPNIVR 88 Query: 420 FYGSESH----RGHLFVCVTLC-EQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 FY S + + + L TL+ L + + R+ I K +Q Sbjct: 89 FYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMK-----PKVLRSWCRQILKGLQF 143 Query: 475 LHLSC-GYTHQDLQPQNILIDSK-KAAHLADFDK--------SIKWAGDP---------- 514 LH H+DL+ NI I + + D + G P Sbjct: 144 LHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEE 203 Query: 515 -QEVKRDLEDLGRLVLYVVKKGSISFEDLKAQS----------NEEVVQLSPDEETKDLI 563 + D+ G +L + + + + + D E K++I Sbjct: 204 HYDESVDVYAFGMCML-EMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEII 262 Query: 564 HRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRK--SESEI-LRLLQP 620 + R + DLL H FF + G ++ S S + LRL Sbjct: 263 EGCIRQNKSERLSIRDLLNHAFF---------AEDTGLRVELAEEDDCSNSSLALRLWVE 313 Query: 621 GPSEHS-KSFDKWTTKINECVMKKMNKFYEKR----GNFYQNTVGDLLKFIRNLGEHIDE 675 P + K D + + + + G F+++ + K IR+ I + Sbjct: 314 DPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTPIKK 373 Query: 676 EKHKK 680 + KK Sbjct: 374 TREKK 378 >2I6L-A nrPDB Length = 320 Score = 104 bits (260), Expect = 1e-22, Method: Composition-based stats. Identities = 42/306 (13%), Positives = 90/306 (29%), Gaps = 91/306 (29%) Query: 371 IADTSEGGIYLGFYEK--QEVAVKTF----CEGSPRAQREVSCLQSSRENSHLVTFY--- 421 + G ++ + VA+K + A RE+ ++ ++ ++V + Sbjct: 19 LGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRL-DHDNIVKVFEIL 77 Query: 422 -----------GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFK 470 GS + +++ E L L+ +E AR + + + Sbjct: 78 GPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLE------QGPLLEEHARLFMYQLLR 131 Query: 471 AVQELHLSCGYTHQDLQPQNILID-SKKAAHLADFDKS------------------IKWA 511 ++ +H S H+DL+P N+ I+ + DF + KW Sbjct: 132 GLKYIH-SANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWY 190 Query: 512 GDP--------QEVKRDLEDLGRLVL-----YVVKKGSISFEDLK--------------- 543 P D+ G + + G+ E ++ Sbjct: 191 RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQ 250 Query: 544 --------------AQSNEEVVQLSP--DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFW 587 + ++ + QL P E D + ++ R + L HP+ Sbjct: 251 ELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYMS 310 Query: 588 TWESRY 593 + Sbjct: 311 IYSFPM 316 >1CM8-A nrPDB Length = 367 Score = 104 bits (259), Expect = 1e-22, Method: Composition-based stats. Identities = 41/360 (11%), Positives = 111/360 (30%), Gaps = 100/360 (27%) Query: 349 DLHRIYRPMIGKLKFFIDEKYK----IADTSEGGIYLGF--YEKQEVAVKTFCEG----- 397 YR + K + + Y+ + + G + +VA+K Sbjct: 7 ARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL 66 Query: 398 -SPRAQREVSCLQSSRENSHLVTFYGSESHR------GHLFVCVTLCEQTLEACLDVHRG 450 + RA RE+ L+ R + +++ + ++ + L + + Sbjct: 67 FAKRAYRELRLLKHMR-HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKL 125 Query: 451 EDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS--- 507 ++ + ++ + K ++ +H + G H+DL+P N+ ++ + DF + Sbjct: 126 ------GEDRIQFLVYQMLKGLRYIHAA-GIIHRDLKPGNLAVNEDCELKILDFGLARQA 178 Query: 508 ---------IKWAGDPQEV--------KRDLEDLGRLVLYVV------------------ 532 +W P+ + D+ +G ++ ++ Sbjct: 179 DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEI 238 Query: 533 --KKGSISFEDLKA-----------------QSNEEVVQLSPDEETKDLIHRLFHPGEHV 573 G+ E ++ + + + + +L+ ++ Sbjct: 239 MKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQ 298 Query: 574 RDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWT 633 R + L HP+F +L + +E ++ + ++ D+W Sbjct: 299 RVTAGEALAHPYF-------ESLHDTEDE----------PQVQKYDDSFDDVDRTLDEWK 341 >4QNY-A nrPDB Length = 354 Score = 104 bits (259), Expect = 2e-22, Method: Composition-based stats. Identities = 48/301 (15%), Positives = 101/301 (33%), Gaps = 86/301 (28%) Query: 365 IDEKYKIADTSEGGIYLGFYEKQE-------VAVKTFCEG-------SPRAQREVSCLQS 410 +D++Y + G Y ++ VA+K + + R RE+ L Sbjct: 18 LDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAH 77 Query: 411 SRENSHLVTFYGSESHRG-----HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVL 465 + +++ + H ++ + + E L+ L G+++ + + + Sbjct: 78 FND-DNIIGLRNILTPEDPENFDHFYIVMDIMETDLKQVL--RSGQELT---EAHIQFFI 131 Query: 466 SSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI---------------KW 510 +A+ +H S G H+D+ P NIL+++ + DF + +W Sbjct: 132 YQALRALHIIH-SAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRW 190 Query: 511 AGDPQEV--------KRDLEDLGRLV--------LY------------VVKKGSISFEDL 542 P+ V + D+ +G ++ L+ V G+ S ED+ Sbjct: 191 YRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDI 250 Query: 543 KA---------------QSNEEVVQLSP--DEETKDLIHRLFHPGEHVRDCLSDLLGHPF 585 + + + Q P E DL+ + R + + HPF Sbjct: 251 NSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPF 310 Query: 586 F 586 Sbjct: 311 L 311 >1TKI-A nrPDB Length = 321 Score = 104 bits (259), Expect = 2e-22, Method: Composition-based stats. Identities = 55/274 (20%), Positives = 95/274 (34%), Gaps = 53/274 (19%) Query: 367 EKYKIADTSEGGIY-----------LGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENS 415 EKY IA+ G + Y + V VK + ++E+S L +R + Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVL--VKKEISILNIAR-HR 61 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 +++ + S L + L+ ++ NE + + + + +A+Q L Sbjct: 62 NILHLHESFESMEELVMIFEFIS-GLDIFERINTSAFELNEREIV--SYVHQVCEALQFL 118 Query: 476 HLSCGYTHQDLQPQNILID--SKKAAHLADFDKSIKWA-GD--------PQE-------- 516 H S H D++P+NI+ + +F ++ + GD P+ Sbjct: 119 H-SHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQH 177 Query: 517 ----VKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDE-----------ETKD 561 D+ LG LV YV+ G F Q E + + E D Sbjct: 178 DVVSTATDMWSLGTLV-YVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMD 236 Query: 562 LIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRT 595 + RL R S+ L HP+ R T Sbjct: 237 FVDRLLVKERKSRMTASEALQHPWLKQKIERVST 270 >4PWN-A nrPDB Length = 274 Score = 104 bits (258), Expect = 2e-22, Method: Composition-based stats. Identities = 46/264 (17%), Positives = 81/264 (30%), Gaps = 52/264 (19%) Query: 368 KYKIADTSEGGIYLGFYEKQEVAV--------KTFCEGSPRAQREVSCLQSSRENSHLVT 419 +I S +Y G + V V K R + E L+ ++ ++V Sbjct: 15 DIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLK-GLQHPNIVR 73 Query: 420 FYGSESH----RGHLFVCVTLC-EQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 FY S + + + L TL+ L + + + R+ I K +Q Sbjct: 74 FYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKI-----KVLRSWCRQILKGLQF 128 Query: 475 LHLSC-GYTHQDLQPQNILIDSK-KAAHLADFDK---------SIKWAGDP--------- 514 LH H+DL+ NI I + + D + G P Sbjct: 129 LHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMYE 188 Query: 515 --QEVKRDLEDLGRLVLYVVKKGSISFED----------LKAQSNEEVVQLSPDEETKDL 562 + D+ G +L + + + + + E K++ Sbjct: 189 EKYDESVDVYAFGMCML-EMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEI 247 Query: 563 IHRLFHPGEHVRDCLSDLLGHPFF 586 I + R + DLL H FF Sbjct: 248 IEGCIRQNKDERYSIKDLLNHAFF 271 >5O2B-A nrPDB Length = 285 Score = 103 bits (257), Expect = 3e-22, Method: Composition-based stats. Identities = 45/263 (17%), Positives = 81/263 (30%), Gaps = 51/263 (19%) Query: 368 KYKIADTSEGGIYLGFYEKQEVAV--------KTFCEGSPRAQREVSCLQSSRENSHLVT 419 ++ + +Y G + V V K R + E L+ ++ ++V Sbjct: 21 DIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLK-GLQHPNIVR 79 Query: 420 FYGSESH----RGHLFVCVTLC-EQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 FY S + + + L TL+ L + + R+ I K +Q Sbjct: 80 FYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMK-----PKVLRSWCRQILKGLQF 134 Query: 475 LHLSC-GYTHQDLQPQNILIDSK-KAAHLADFDK--------SIKWAGDP---------- 514 LH H+DL+ NI I + + D + G P Sbjct: 135 LHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEE 194 Query: 515 -QEVKRDLEDLGRLVLYVVKKGSISFEDLKAQS----------NEEVVQLSPDEETKDLI 563 + D+ G +L + + + + + D E K++I Sbjct: 195 HYDESVDVYAFGMCML-EMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEII 253 Query: 564 HRLFHPGEHVRDCLSDLLGHPFF 586 + R + DLL H FF Sbjct: 254 EGCIRQNKSERLSIRDLLNHAFF 276 >3LJN-A nrPDB Length = 364 Score = 103 bits (257), Expect = 3e-22, Method: Composition-based stats. Identities = 60/300 (20%), Positives = 118/300 (39%), Gaps = 25/300 (8%) Query: 54 QEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLS 113 + ++ +H A + + D V L+ G P ++ + G T LA G V K S Sbjct: 15 KSDDENMEKIHVAARKGQTDEVRRLIETGVSPTIQNRFGCTALHLACKFGCVDTAKYLAS 74 Query: 114 KGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRK------- 166 G +V+ ++G A + K + L + ++ ++ R+ Sbjct: 75 VG-EVHSL-WHGQKPIHLAVMANKTDLVVALVEGAKERGQMPESLLNECDEREVNEIGSH 132 Query: 167 ----GGATALMDAAEKG--HVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEA 220 G TAL G ++E++KIL+ ++GA A D L+ A+ + ++ Sbjct: 133 VKHCKGQTALHWCVGLGPEYLEMIKILV-QLGASPTAKDKADETPLMRAMEFRNREALDL 191 Query: 221 ITHLLLDHGA-DVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLL 279 + + + ++ ++G + L A+ + R +E I++N D++ L L Sbjct: 192 MMDTVPSKSSLRLDYANKQGNSHLHWAILINWEDVAMRFVEM-GIDVNMEDNEHTVPLYL 250 Query: 280 AVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQ 339 +V + + + L ++ D+ + Y H+ VL DF P A D Q Sbjct: 251 SVRAAMVLLTKELLQK------TDVFLIQACPY-HNGTTVLPDRVVWLDFVPAAADPSKQ 303 Score = 102 bits (254), Expect = 6e-22, Method: Composition-based stats. Identities = 62/286 (21%), Positives = 104/286 (36%), Gaps = 50/286 (17%) Query: 12 GPT-----SSSGR-RAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHN 65 GP R ++ E+ + A + D V++L+E G + Q G T LH Sbjct: 1 GPGSMTDFPKLNRIKSDDENMEKIHVAARKGQTDEVRRLIETGVSPTIQNRFG-CTALHL 59 Query: 66 AVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLF-------------L 112 A + D + L G +G P LA +A L+ L Sbjct: 60 ACKFGCVDTAKYLASVGE-VHSL-WHGQKPIHLAVMANKTDLVVALVEGAKERGQMPESL 117 Query: 113 SKGAD---VNECDF-----YGFTAFMEAAVYG--KVKALKFLYKRGANVNLRRKTKEDQE 162 D VNE G TA G ++ +K L + GA+ + K E Sbjct: 118 LNECDEREVNEIGSHVKHCKGQTALHWCVGLGPEYLEMIKILVQLGASPTAKDKADE--- 174 Query: 163 RLRKGGATALMDAAEKGHVEVLKILLDEMGAD----VNACDNMGRNALIHALLSSDDSDV 218 T LM A E + E L +++D + + ++ + G + L + + Sbjct: 175 -------TPLMRAMEFRNREALDLMMDTVPSKSSLRLDYANKQGNSHLH----WAILINW 223 Query: 219 EAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHI 264 E + ++ G DVN+ PL L+V + L + LL++ + Sbjct: 224 EDVAMRFVEMGIDVNMEDNEHTVPLYLSVRAAMVLLTKELLQKTDV 269 >5EFQ-A nrPDB Length = 347 Score = 103 bits (256), Expect = 4e-22, Method: Composition-based stats. Identities = 46/275 (16%), Positives = 96/275 (34%), Gaps = 65/275 (23%) Query: 371 IADTSEGGIYLGFYEK--QEVAVKTFC-----EGSP-RAQREVSCLQSSRENSHLVTF-- 420 I + + G +Y + + VA+K EG P A RE+ L+ + ++ Sbjct: 19 IGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLT-HQSIINMKE 77 Query: 421 --------YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAV 472 + +G ++ + L L+ + + + ++ + + + + Sbjct: 78 IVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLES----GLVHFNENHIKSFMRQLMEGL 133 Query: 473 QELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI------------------------ 508 H + H+D++ NIL++++ LADF + Sbjct: 134 DYCHKK-NFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPEL 192 Query: 509 KWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHR-LF 567 + D+ G +L + F Q+N+E+ QL +LI R Sbjct: 193 LLGEERYTPAIDVWSCGC-ILGELFTKKPIF-----QANQELAQL-------ELISRICG 239 Query: 568 HPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNE 602 P V D++ P+F T + + + R + E Sbjct: 240 SPCPAVWP---DVIKLPYFNTMKPKKQYRRKLREE 271 >4RA4-A nrPDB Length = 355 Score = 102 bits (254), Expect = 6e-22, Method: Composition-based stats. Identities = 49/290 (16%), Positives = 92/290 (31%), Gaps = 47/290 (16%) Query: 332 PAEDWK-PQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVA 390 P+ED K P ++ L D + + G + K + Y K++V Sbjct: 3 PSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEEL----YAIKILKKDVV 58 Query: 391 VKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRG 450 ++ ++ V L + L + L+ + ++ Sbjct: 59 IQDDDVECTMVEKRVLAL--LDKPPFLTQLHSCFQTVDRLYFVMEYVNGGD----LMYHI 112 Query: 451 EDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK- 509 + V ++ A + I + LH G ++DL+ N+++DS+ +ADF + Sbjct: 113 QQVGKFKEPQAVFYAAEISIGLFFLH-KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEH 171 Query: 510 ---------WAGDPQEV------------KRDLEDLGRLVLYVVKKGSISF-----EDLK 543 + G P + D G ++LY + G F ++L Sbjct: 172 MMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYG-VLLYEMLAGQPPFDGEDEDELF 230 Query: 544 AQSNEEVV--QLSPDEETKDLIHRLFHPGEHVRDCL-----SDLLGHPFF 586 E V S +E + L R D+ H FF Sbjct: 231 QSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFF 280 >5HI2-A nrPDB Length = 283 Score = 102 bits (254), Expect = 6e-22, Method: Composition-based stats. Identities = 48/253 (18%), Positives = 89/253 (35%), Gaps = 49/253 (19%) Query: 370 KIADTSEGGIYLGFYEKQEVAVKTF-CEGSPRAQREVSCLQSSRENSHLVTFYGSESHRG 428 +I S G +Y G + +VAVK + + EV L+ +R + +++ F G S + Sbjct: 27 RIGSGSFGTVYKGKWHG-DVAVKMLTPQQLQAFKNEVGVLRKTR-HVNILLFMG-YSTKP 83 Query: 429 HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQP 488 L + CE + L H E + ++ + + LH H+DL+ Sbjct: 84 QLAIVTQWCEGSS---LYHHLHASETKFEMKKLIDIARQTARGMDYLHAK-SIIHRDLKS 139 Query: 489 QNILIDSKKAAHLADFDKSI---KWAG------------------------DPQEVKRDL 521 NI + + DF + +W+G +P + D+ Sbjct: 140 NNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNPYSFQSDV 199 Query: 522 EDLGRLVLYVVKKGSISFEDLKAQSNEEVVQ----LSPD---------EETKDLIHRLFH 568 G +VLY + G + + ++ + + LSPD + K L+ Sbjct: 200 YAFG-IVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLK 258 Query: 569 PGEHVRDCLSDLL 581 R +L Sbjct: 259 KKRDERPSFPRIL 271 >5O0Y-A nrPDB Length = 579 Score = 102 bits (254), Expect = 6e-22, Method: Composition-based stats. Identities = 70/369 (18%), Positives = 115/369 (31%), Gaps = 89/369 (24%) Query: 307 TARRNYDHSLVKVLLS--HGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFF 364 TA HSL+++ L+ H +E F K + + A L+ L R+ I +LK Sbjct: 209 TAPALGAHSLLRLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRI 268 Query: 365 -------------IDEKYKIADTSEGGIYLGFYEK------QEVAVK-----------TF 394 ++++Y + G + Y+ + VAVK Sbjct: 269 HNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKK 328 Query: 395 CEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLF-VCVTLCEQTLEACLDVHRGEDV 453 A RE + ++ +V Y S F + CE LD + + Sbjct: 329 ENYHKHACREYRIHKEL-DHPRIVKLYDYFSLDTDSFCTVLEYCEGN---DLDFYLKQHK 384 Query: 454 ENEEDEFARNVLSSIFKAVQELHL-SCGYTHQDLQPQNILI---DSKKAAHLADFDKSIK 509 E E AR+++ I A++ L+ H DL+P NIL+ + + DF S Sbjct: 385 LMSEKE-ARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKI 443 Query: 510 WAGDPQ---------------------------------EVKRDLEDLGRLVLYVVKKGS 536 D K D+ +G ++ Y G Sbjct: 444 MDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVG-VIFYQCLYGR 502 Query: 537 ISFEDLKAQS---------NEEVVQLSP----DEETKDLIHRLFHPGEHVRDCLSDLLGH 583 F ++Q VQ P E K I R + R + L Sbjct: 503 KPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACD 562 Query: 584 PFFWTWESR 592 P+ + Sbjct: 563 PYLLPHIRK 571 >6DMR-A nrPDB Length = 730 Score = 102 bits (254), Expect = 6e-22, Method: Composition-based stats. Identities = 55/269 (20%), Positives = 100/269 (37%), Gaps = 35/269 (13%) Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSK-GADVNECDFYGFTAFMEAAVYGKVKALKFLYK 146 +++ +P + AA ++LLK+ L D + G TA AA+Y ++A L + Sbjct: 41 QERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLME 100 Query: 147 RGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNAC-----DNM 201 + E G TAL A ++ +++ LL GA V+A Sbjct: 101 AAPELAKEPALCE-----PFVGQTALHIAVMNQNLNLVRALLAR-GASVSARATGAAFRR 154 Query: 202 GRNALI----HALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLG---- 253 + LI H L + E I LL++HGAD+ + G T L + + + + Sbjct: 155 SPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQ 214 Query: 254 LVQRLLEQEHIEINDT------DSDGKTALLLAVELKLKKIAELLCKRGASTD------- 300 + LL + + + G T LA + + L ++ Sbjct: 215 MYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLT 274 Query: 301 --CGDLVMTARRNYDHSLVKVLLSHGAKE 327 DL + S +++++S +E Sbjct: 275 STLYDLTEIDSWGEELSFLELVVSSKKRE 303 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 59/264 (22%), Positives = 115/264 (43%), Gaps = 32/264 (12%) Query: 54 QEEEGGWTPLHNAVQMSREDIVELLLRHGA-DPVLRKKNGATPFILAAIAGSVKLLKLFL 112 Q+E +PL A + + ++++LL + + D R G T +AA+ +++ L + Sbjct: 40 QQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLM 99 Query: 113 SKGADVNECDFY------GFTAFMEAAVYGKVKALKFLYKRGANVNLRRK---TKEDQER 163 ++ + G TA A + + ++ L RGA+V+ R + Sbjct: 100 EAAPEL-AKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHN 158 Query: 164 LRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITH 223 L G L AA G E++++L+ E GAD+ A D++G L +L + + + + Sbjct: 159 LIYYGEHPLSFAACVGSEEIVRLLI-EHGADIRAQDSLGNTVLHILILQPNKTFACQMYN 217 Query: 224 LLLDHGADVN-------VRGERGKTPLILAVEKKHLGLVQRLL-EQEHI----------- 264 LLL + + V +G TP LA + + + Q L+ +++H+ Sbjct: 218 LLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTL 277 Query: 265 -EINDTDSDGKTALLLAVELKLKK 287 ++ + DS G+ L + + KK Sbjct: 278 YDLTEIDSWGEELSFLELVVSSKK 301 Score = 65.9 bits (159), Expect = 6e-11, Method: Composition-based stats. Identities = 37/165 (22%), Positives = 58/165 (35%), Gaps = 37/165 (22%) Query: 15 SSSGRRAA----VEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEG------------ 58 + A L AV N++++LV+ LL GA+V+ + Sbjct: 103 PELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYY 162 Query: 59 GWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFIL---------AAIAGSVKLLK 109 G PL A + E+IV LL+ HGAD + G T + A ++ Sbjct: 163 GEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNL---- 218 Query: 110 LFLSKGADVNE-------CDFYGFTAFMEAAVYGKVKALKFLYKR 147 LS + + G T F A V G + L ++ Sbjct: 219 -LLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 Score = 60.9 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 36/176 (20%), Positives = 69/176 (39%), Gaps = 23/176 (13%) Query: 154 RRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSS 213 + + + + + + + L+ AA++ + +LKILL D +G AL A L Sbjct: 31 QYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAAL-- 88 Query: 214 DDSDVEAITHLLLDHGADVNVRGER-----GKTPLILAVEKKHLGLVQRLLEQEHIEIND 268 D LL++ ++ G+T L +AV ++L LV+ LL + ++ Sbjct: 89 --YDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLAR-GASVSA 145 Query: 269 TDS-------------DGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRN 311 + G+ L A + ++I LL + GA D + + Sbjct: 146 RATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLH 201 >3NYO-A nrPDB Length = 576 Score = 102 bits (254), Expect = 7e-22, Method: Composition-based stats. Identities = 38/223 (17%), Positives = 71/223 (31%), Gaps = 42/223 (18%) Query: 401 AQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEF 460 A E L+ + +V+ + + L + +TL H G+ + Sbjct: 231 ALNEKQILEKV-NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ--AGFPEAR 287 Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK----------- 509 A + I +++LH ++DL+P+NIL+D ++D ++ Sbjct: 288 AVFYAAEICCGLEDLHRE-RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV 346 Query: 510 ----------WAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQL------ 553 + D LG L LY + G F+ K + E V+ Sbjct: 347 GTVGYMAPEVVKNERYTFSPDWWALGCL-LYEMIAGQSPFQQRKKKIKREEVERLVKEVP 405 Query: 554 -----SPDEETKDLIHRLFHPGEHVRD-----CLSDLLGHPFF 586 + + L +L R ++ HP F Sbjct: 406 EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 >3DLS-A nrPDB Length = 335 Score = 102 bits (253), Expect = 8e-22, Method: Composition-based stats. Identities = 51/304 (16%), Positives = 100/304 (32%), Gaps = 53/304 (17%) Query: 366 DEKYKIADTSEGGIY------LGFYEKQEVAVK-----TFCEGS-------PRAQREVSC 407 +KY G + + + +EV VK E + E++ Sbjct: 23 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAI 82 Query: 408 LQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSS 467 L E+++++ ++G + + L+ + R ++ + A + Sbjct: 83 LSRV-EHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLD---EPLASYIFRQ 138 Query: 468 IFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI---------KWAGDPQEV- 517 + AV L L H+D++ +NI+I L DF + + G + Sbjct: 139 LVSAVGYLRLK-DIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCA 197 Query: 518 ------------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEV-VQLSPDEETKDLIH 564 + ++ LG + LY + F +L+ + +E L+ Sbjct: 198 PEVLMGNPYRGPELEMWSLG-VTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVS 256 Query: 565 RLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILR--LLQPGP 622 L P R L L+ P+ + L + E + K ES +L L+ G Sbjct: 257 GLLQPVPERRTTLEKLVTDPWVT----QPVNLADYTWEEVFRVNKPESGVLSAASLEMGN 312 Query: 623 SEHS 626 S Sbjct: 313 RSLS 316 >2H8H-A nrPDB Length = 535 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 53/265 (20%), Positives = 96/265 (36%), Gaps = 44/265 (16%) Query: 368 KYKIADTSEGGIYLGFYEKQE-VAVKTFCEG--SPRA-QREVSCLQSSRENSHLVTFYGS 423 + K+ G +++G + VA+KT G SP A +E ++ R + LV Y Sbjct: 272 EVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR-HEKLVQLYAV 330 Query: 424 ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTH 483 S +++ + + LD +GE + ++ + I + + Y H Sbjct: 331 VSEEP-IYIVTEYMSKG--SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV-ERMNYVH 386 Query: 484 QDLQPQNILIDSKKAAHLADFDKS-----------------IKWAG------DPQEVKRD 520 +DL+ NIL+ +ADF + IKW +K D Sbjct: 387 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 446 Query: 521 LEDLGRLVLYVVKKGSISF------EDLKAQSNEEVVQLSPD--EETKDLIHRLFHPGEH 572 + G L+ + KG + + E L + P+ E DL+ + + Sbjct: 447 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPE 506 Query: 573 VRDC---LSDLLGHPFFWTWESRYR 594 R L L +F + E +Y+ Sbjct: 507 ERPTFEYLQAFLED-YFTSTEPQYQ 530 >5HIE-A nrPDB Length = 302 Score = 100 bits (250), Expect = 2e-21, Method: Composition-based stats. Identities = 45/253 (17%), Positives = 88/253 (34%), Gaps = 49/253 (19%) Query: 370 KIADTSEGGIYLGFYEKQEVAVKTF-CEGSPRAQREVSCLQSSRENSHLVTFYGSESHRG 428 +I S G +Y G + +VAVK + + EV L+ +R + +++ F G S + Sbjct: 43 RIGSGSFGTVYKGKWHG-DVAVKMLTPQQLQAFKNEVGVLRKTR-HVNILLFMG-YSTKP 99 Query: 429 HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQP 488 L + CE + +H E E ++ + + LH H+DL+ Sbjct: 100 QLAIVTQWCEGS-SLYHHLHIIETK--FEMIKLIDIARQTAQGMDYLHAK-SIIHRDLKS 155 Query: 489 QNILIDSKKAAHLADFDKSI---KWAG------------------------DPQEVKRDL 521 NI + + DF + +W+G +P + D+ Sbjct: 156 NNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDV 215 Query: 522 EDLGRLVLYVVKKGSISFEDLKAQ-------------SNEEVVQLSPDEETKDLIHRLFH 568 G +VLY + G + + ++ + + V+ + + K L+ Sbjct: 216 YAFG-IVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLK 274 Query: 569 PGEHVRDCLSDLL 581 R +L Sbjct: 275 KKRDERPLFPQIL 287 >4NST-A nrPDB Length = 351 Score = 100 bits (249), Expect = 2e-21, Method: Composition-based stats. Identities = 41/295 (13%), Positives = 84/295 (28%), Gaps = 86/295 (29%) Query: 371 IADTSEGGIYLGFYEK--QEVAVKTFC-----EGSP-RAQREVSCLQSSRENSHLVTF-- 420 I + + G +Y + + VA+K EG P A RE+ L+ + +V Sbjct: 21 IGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLI-HRSVVNMKE 79 Query: 421 --------YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAV 472 + +G ++ + L L+ + + ++ ++ + + + + Sbjct: 80 IVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLES----GLVHFSEDHIKSFMKQLMEGL 135 Query: 473 QELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI------------------------ 508 + H + H+D++ NIL+++ LADF + Sbjct: 136 EYCHKK-NFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPEL 194 Query: 509 KWAGDPQEVKRDLEDLGRLV--------------------LYVVKKGSI-S--------- 538 + D+ G ++ L GS Sbjct: 195 LLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKL 254 Query: 539 --FEDLK-----AQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 F +K + E P DL+ + R L F Sbjct: 255 PYFNTMKPKKQYRRRLREEFSFIPSA-ALDLLDHMLTLDPSKRCTAEQTLQSDFL 308 >4FR4-A nrPDB Length = 384 Score = 100 bits (249), Expect = 2e-21, Method: Composition-based stats. Identities = 47/251 (18%), Positives = 90/251 (35%), Gaps = 44/251 (17%) Query: 371 IADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHL 430 + +Y Y ++ V+ +E+ +Q E+ LV + S + Sbjct: 34 VQKNDTKKMYAMKYMNKQKCVER--NEVRNVFKELQIMQ-GLEHPFLVNLWYSFQDEEDM 90 Query: 431 FVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQN 490 F+ V L L L H ++V + ++E + + + A+ L + H+D++P N Sbjct: 91 FMVVDLL---LGGDLRYHLQQNV-HFKEETVKLFICELVMALDYL-QNQRIIHRDMKPDN 145 Query: 491 ILIDSKKAAHLADFDKSIKW------------------------AGDPQEVKRDLEDLGR 526 IL+D H+ DF+ + G D LG Sbjct: 146 ILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGAGYSFAVDWWSLG- 204 Query: 527 LVLYVVKKGSISFEDLKAQSNEEVV----------QLSPDEETKDLIHRLFHPGEHVRDC 576 + Y + +G + + S++E+V + +E L+ +L P R Sbjct: 205 VTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFS 264 Query: 577 -LSDLLGHPFF 586 LSD+ P+ Sbjct: 265 QLSDVQNFPYM 275 >6F3F-A nrPDB Length = 455 Score = 100 bits (249), Expect = 2e-21, Method: Composition-based stats. Identities = 53/265 (20%), Positives = 96/265 (36%), Gaps = 44/265 (16%) Query: 368 KYKIADTSEGGIYLGFYEKQE-VAVKTFCEG--SPRA-QREVSCLQSSRENSHLVTFYGS 423 + K+ G +++G + VA+KT G SP A +E ++ R + LV Y Sbjct: 192 EVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR-HEKLVQLYAV 250 Query: 424 ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTH 483 S +++ + + LD +GE + ++ + I + + Y H Sbjct: 251 VSEEP-IYIVTEYMNKG--SLLDFLKGETGKYLRLPQLVDMSAQIASGMAYV-ERMNYVH 306 Query: 484 QDLQPQNILIDSKKAAHLADFDKS-----------------IKWAG------DPQEVKRD 520 +DL+ NIL+ +ADF + IKW +K D Sbjct: 307 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 366 Query: 521 LEDLGRLVLYVVKKGSISF------EDLKAQSNEEVVQLSPD--EETKDLIHRLFHPGEH 572 + G L+ + KG + + E L + P+ E DL+ + + Sbjct: 367 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPE 426 Query: 573 VRDC---LSDLLGHPFFWTWESRYR 594 R L L +F + E +Y+ Sbjct: 427 ERPTFEYLQAFLED-YFTSTEPQYQ 450 >3MIA-A nrPDB Length = 351 Score = 100 bits (249), Expect = 2e-21, Method: Composition-based stats. Identities = 56/300 (18%), Positives = 95/300 (31%), Gaps = 87/300 (29%) Query: 370 KIADTSEGGIYLGFYEK--QEVAVKTFC-----EGSP-RAQREVSCLQSSRENSHLVTFY 421 KI + G ++ + K Q+VA+K EG P A RE+ LQ ++ ++V Sbjct: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ-LLKHENVVNLI 82 Query: 422 GSESHR--------GHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQ 473 + G +++ CE L L + +E + V+ + + Sbjct: 83 EICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE----IKRVMQMLLNGLY 138 Query: 474 ELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKR-------------- 519 +H + H+D++ N+LI LADF + ++ Sbjct: 139 YIHRN-KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Query: 520 -------------DLEDLGRLV--------------------LYVVKKGSIS-------- 538 DL G ++ L GSI+ Sbjct: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD 257 Query: 539 ----FEDL------KAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWT 588 +E L K + + + D DLI +L R D L H FFW+ Sbjct: 258 NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS 317 >5SYS-A nrPDB Length = 286 Score = 100 bits (248), Expect = 3e-21, Method: Composition-based stats. Identities = 53/265 (20%), Positives = 95/265 (35%), Gaps = 44/265 (16%) Query: 368 KYKIADTSEGGIYLGFYEKQE-VAVKTFCEG--SPRA-QREVSCLQSSRENSHLVTFYGS 423 + K+ G ++G + VA+KT G SP A +E ++ R + LV Y Sbjct: 23 EVKLGQGCFGECWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR-HEKLVQLYAV 81 Query: 424 ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTH 483 S +++ + + LD +GE + ++ + I + + Y H Sbjct: 82 VSEEP-IYIVTEYMSKG--SLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYV-ERMNYVH 137 Query: 484 QDLQPQNILIDSKKAAHLADFDKS-----------------IKWAG------DPQEVKRD 520 +DL+ NIL+ +ADF + IKW +K D Sbjct: 138 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 197 Query: 521 LEDLGRLVLYVVKKGSISF------EDLKAQSNEEVVQLSPD--EETKDLIHRLFHPGEH 572 + G L+ + KG + + E L + P+ E DL+ + + Sbjct: 198 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPE 257 Query: 573 VRDC---LSDLLGHPFFWTWESRYR 594 R L L +F + E +Y+ Sbjct: 258 ERPTFEYLQAFLED-YFTSTEPQYQ 281 >4H1J-A nrPDB Length = 293 Score = 99.4 bits (246), Expect = 5e-21, Method: Composition-based stats. Identities = 42/254 (16%), Positives = 78/254 (30%), Gaps = 51/254 (20%) Query: 371 IADTSEGGIYLGFYEKQ-----EVAVKTFCEGSPRAQREV----SCLQSSRENSHLVTFY 421 + + G +Y G Y VAVKT + +E + + + ++ H+V Sbjct: 32 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLI 91 Query: 422 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 G ++ + L ++ I KA+ L S Sbjct: 92 GIIEEEPT-WIIMELYPYGELGHYLERNKNSLKVLTLVL---YSLQICKAMAYL-ESINC 146 Query: 482 THQDLQPQNILIDSKKAAHLADFDKS-----------------IKWAGDPQEV------- 517 H+D+ +NIL+ S + L DF S IKW P+ + Sbjct: 147 VHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWM-SPESINFRRFTT 205 Query: 518 KRDLEDLGRLVLYVVKKGSISFEDLKAQ----------SNEEVVQLSPDEETKDLIHRLF 567 D+ + ++ G F L+ + + P L+ R + Sbjct: 206 ASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPP--VLYTLMTRCW 263 Query: 568 HPGEHVRDCLSDLL 581 R ++L+ Sbjct: 264 DYDPSDRPRFTELV 277 >4O2Z-A nrPDB Length = 377 Score = 99.0 bits (245), Expect = 6e-21, Method: Composition-based stats. Identities = 45/296 (15%), Positives = 95/296 (32%), Gaps = 74/296 (25%) Query: 363 FFIDEKYKIADTSEGGIY------LGFYEKQEVAVKTFC------EGSPRAQREVSCLQS 410 F + KY + G Y L ++V++K E R RE+ ++ Sbjct: 41 FEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRF 100 Query: 411 SRENS--HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 + ++V H F V + ++ ++V + E+ + + I Sbjct: 101 FHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVL-RSRQVLEESHMQYFVYQI 159 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK------------------- 509 + ++ LH S H+DL+P N++ + + DF S Sbjct: 160 LRGLKYLH-SANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRP 218 Query: 510 ----WAGDPQEVKRDLEDLGRLV--LY---VVKKGSISFEDLK----------------A 544 D+ +G + +Y V G + + L+ Sbjct: 219 PELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHR 278 Query: 545 QSNEEVVQLSP--------------DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 ++ E++ +L + E D + +++ R +D+L HP+ Sbjct: 279 EALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYL 334 >3GC9-A nrPDB Length = 370 Score = 98.6 bits (244), Expect = 9e-21, Method: Composition-based stats. Identities = 43/294 (14%), Positives = 97/294 (32%), Gaps = 81/294 (27%) Query: 371 IADTSEGGIYLGF--YEKQEVAVKTFCEGSP------RAQREVSCLQSSRENSHLVTFYG 422 + + G + + +Q+VAVK R RE+ L+ ++ +++ Sbjct: 36 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL-KHENVIGLLD 94 Query: 423 SE------SHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 +++ TL L ++ + + + DE + ++ + + ++ +H Sbjct: 95 VFTPATSIEDFSEVYLVTTLMGADLN---NIVKSQAL---SDEHVQFLVYQLLRGLKYIH 148 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDK------------SIKWAGDPQEV------- 517 S G H+DL+P N+ ++ + DF + +W P+ + Sbjct: 149 -SAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYN 207 Query: 518 -KRDLEDLGRLVLYVVKKGSISF------EDLKA-------------------------Q 545 D+ +G ++ + +G F + LK Q Sbjct: 208 QTVDIWSVGCIMA-ELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQ 266 Query: 546 SNEEVVQLSPDEETK-------DLIHRLFHPGEHVRDCLSDLLGHPFFWTWESR 592 S + Q + DL+ R+ R ++ L H +F + Sbjct: 267 SLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 320 >4TNB-A nrPDB Length = 590 Score = 98.6 bits (244), Expect = 1e-20, Method: Composition-based stats. Identities = 43/237 (18%), Positives = 79/237 (33%), Gaps = 43/237 (18%) Query: 387 QEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLD 446 ++ +K +G A E L+ + +V + + L + +T+ Sbjct: 218 EKKRIKK-RKGESMALNEKQILEKV-NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHI 275 Query: 447 VHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDK 506 + G E+E A + I +++LH ++DL+P+NIL+D ++D Sbjct: 276 YNMGN--PGFEEERALFYAAEILCGLEDLHHE-NTVYRDLKPENILLDDYGHIRISDLGL 332 Query: 507 SIK---------------------WAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQ 545 ++K + D LG L+ Y + +G F K + Sbjct: 333 AVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLI-YEMIEGQSPFRGRKEK 391 Query: 546 SNEEVVQLSP-----------DEETKDLIHRLFHPGEHVRD-----CLSDLLGHPFF 586 E V EE K + L R +++ HPFF Sbjct: 392 VKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFF 448 >6NPU-A nrPDB Length = 298 Score = 98.2 bits (243), Expect = 1e-20, Method: Composition-based stats. Identities = 45/250 (18%), Positives = 87/250 (34%), Gaps = 42/250 (16%) Query: 368 KYKIADTSEGGIYLGFYEKQE--VAVKTFCEGSPRAQ---REVSCLQSSRENSHLVTFYG 422 K+K+ G +Y G ++K VAVKT E + + +E + ++ ++ +LV G Sbjct: 31 KHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI-KHPNLVQLLG 89 Query: 423 SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYT 482 + ++ LD R + + + + I A++ L + Sbjct: 90 VCTREPPFYIITEFMTYG--NLLDYLRECNRQEVNAVVLLYMATQISSAMEYL-EKKNFI 146 Query: 483 HQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQ-----------------------EVKR 519 H+DL +N L+ +ADF S GD +K Sbjct: 147 HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKS 206 Query: 520 DLEDLGRLVLYVVKKGSIS---------FEDLKAQSNEEVVQLSPDEETKDLIHRLFHPG 570 D+ G L+ + G +E L+ E + P E+ +L+ + Sbjct: 207 DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP-EKVYELMRACWQWN 265 Query: 571 EHVRDCLSDL 580 R +++ Sbjct: 266 PSDRPSFAEI 275 >4XEY-B nrPDB Length = 408 Score = 98.2 bits (243), Expect = 1e-20, Method: Composition-based stats. Identities = 45/250 (18%), Positives = 87/250 (34%), Gaps = 42/250 (16%) Query: 368 KYKIADTSEGGIYLGFYEKQE--VAVKTFCEGSPRAQ---REVSCLQSSRENSHLVTFYG 422 K+K+ G +Y G ++K VAVKT E + + +E + ++ ++ +LV G Sbjct: 130 KHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI-KHPNLVQLLG 188 Query: 423 SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYT 482 + ++ LD R + + + + I A++ L + Sbjct: 189 VCTREPPFYIITEFMTYG--NLLDYLRECNRQEVNAVVLLYMATQISSAMEYL-EKKNFI 245 Query: 483 HQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQ-----------------------EVKR 519 H+DL +N L+ +ADF S GD +K Sbjct: 246 HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKS 305 Query: 520 DLEDLGRLVLYVVKKGSIS---------FEDLKAQSNEEVVQLSPDEETKDLIHRLFHPG 570 D+ G L+ + G +E L+ E + P E+ +L+ + Sbjct: 306 DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP-EKVYELMRACWQWN 364 Query: 571 EHVRDCLSDL 580 R +++ Sbjct: 365 PSDRPSFAEI 374 >5UUU-A nrPDB Length = 547 Score = 98.2 bits (243), Expect = 1e-20, Method: Composition-based stats. Identities = 54/338 (15%), Positives = 109/338 (32%), Gaps = 60/338 (17%) Query: 367 EKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESH 426 E Y G +Y ++ E +R + L S+ + +V + Sbjct: 213 EVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHT 272 Query: 427 RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDL 486 L + L L H + E + R + I ++ +H + ++DL Sbjct: 273 PDKLSFILDLMNGG---DLHYHLSQHGVFSEADM-RFYAAEIILGLEHMH-NRFVVYRDL 327 Query: 487 QPQNILIDSKKAAHLADFDKSIKWA---------------------GDPQEVKRDLEDLG 525 +P NIL+D ++D + ++ G + D LG Sbjct: 328 KPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLG 387 Query: 526 RLVLYVVKKGSISFEDLKAQSNEEVVQL----------SPDEETKDLIHRLFHPGEHVRD 575 +L+ + +G F K + E+ ++ S E + L+ L + R Sbjct: 388 C-MLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRL 446 Query: 576 -----CLSDLLGHPFFWTWESRYRTLR-------------NVGNESDIKTRKSESEILRL 617 ++ PFF + + + L+ N + DI + E Sbjct: 447 GCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIK 506 Query: 618 LQPGPSEHSKSF-----DKWTTKINECVMKKMNKFYEK 650 L E ++F ++W ++ E V +N ++ Sbjct: 507 LLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDR 544 >5MJB-A nrPDB Length = 305 Score = 97.8 bits (242), Expect = 1e-20, Method: Composition-based stats. Identities = 48/267 (17%), Positives = 90/267 (33%), Gaps = 51/267 (19%) Query: 361 LKFFIDEKYKIADTSEGGIYLGFYE---KQE--VAVKTFCEGSPRAQR-----EVSCLQS 410 + F E+ I G +Y G + K+E VA+KT G QR E S + Sbjct: 25 VSFVKIEE-VIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQ 83 Query: 411 SRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFK 470 ++ +++ G + + + E LD ++ +L I Sbjct: 84 F-DHRNIIRLEGVVTKSRPVMIITEFMENCA---LDSFLRQNDGQFTVIQLVGMLRGIAA 139 Query: 471 AVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI---KWAGDPQEVK--------- 518 ++ L Y H+DL +NIL++S ++DF S DP Sbjct: 140 GMKYL-SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVR 198 Query: 519 ---------------RDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQ----LSPDEET 559 D+ G ++ V+ G + D+ Q ++ L P + Sbjct: 199 WTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDC 258 Query: 560 KDLIHRLF----HPGEHVRDCLSDLLG 582 +H+L + R ++++ Sbjct: 259 PAALHQLMLDCWQKDRNSRPRFAEIVN 285 >1AD5-A nrPDB Length = 438 Score = 97.8 bits (242), Expect = 1e-20, Method: Composition-based stats. Identities = 48/253 (18%), Positives = 101/253 (39%), Gaps = 34/253 (13%) Query: 370 KIADTSEGGIYLGFYEKQ-EVAVKTFCEGSPRAQR---EVSCLQSSRENSHLVTFYGSES 425 K+ G +++ Y K +VAVKT GS + E + ++ + ++ LV + + Sbjct: 189 KLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMK-TLQHDKLVKLHAVVT 247 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 +++ + + LD + ++ + + + I + + + Y H+D Sbjct: 248 KEP-IYIITEFMAKG--SLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFI-EQRNYIHRD 303 Query: 486 LQPQNILIDSKKAAHLADFDKS-------IKWAG------DPQEVKRDLEDLGRLVLYVV 532 L+ NIL+ + +ADF + IKW +K D+ G L++ +V Sbjct: 304 LRAANILVSASLVCKIADFGLARVGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIV 363 Query: 533 KKGSISF------EDLKAQSNEEVVQLSPD--EETKDLIHRLFHPGEHVRDC---LSDLL 581 G I + E ++A + + EE +++ R + R + +L Sbjct: 364 TYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVL 423 Query: 582 GHPFFWTWESRYR 594 F+ ES+Y+ Sbjct: 424 DD-FYTATESQYQ 435 >3EHQ-A nrPDB Length = 222 Score = 97.8 bits (242), Expect = 1e-20, Method: Composition-based stats. Identities = 31/102 (30%), Positives = 44/102 (43%), Gaps = 4/102 (3%) Query: 203 RNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQE 262 N L A + S + LD+ VN + G T L A H +V+ L Q Sbjct: 74 DNPLHEAAKRGNLSWLREC----LDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQP 129 Query: 263 HIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDL 304 +IE+N + G TAL A I +LL +GA TD ++ Sbjct: 130 NIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNI 171 Score = 82.4 bits (202), Expect = 6e-16, Method: Composition-based stats. Identities = 27/127 (21%), Positives = 51/127 (40%), Gaps = 2/127 (1%) Query: 62 PLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFL-SKGADVNE 120 PLH A + + L + K G+T A G ++++ ++N+ Sbjct: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135 Query: 121 CDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGH 180 + G TA AA G ++ L +GA +LR K+ + A A + ++G Sbjct: 136 QNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLLKKKQG- 194 Query: 181 VEVLKIL 187 + ++ L Sbjct: 195 TDAVRTL 201 Score = 75.9 bits (185), Expect = 6e-14, Method: Composition-based stats. Identities = 38/157 (24%), Positives = 65/157 (41%), Gaps = 9/157 (5%) Query: 13 PTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSRE 72 P++ +A DN L +A + ++ +++ L+ VN ++ G T L+ A + Sbjct: 62 PSNYVAEQAESIDN-PLHEAAKRGNLSWLRECLDNRVGVNGLDKAG-STALYWACHGGHK 119 Query: 73 DIVELLL-RHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFME 131 DIVE+L + + + K G T AA G +++L L+KGA + + AF Sbjct: 120 DIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDM 179 Query: 132 AAVYGKVKALKFLYKR--GANVNLRRKTKEDQERLRK 166 A A L K+ G + ED Sbjct: 180 ATNA----ACASLLKKKQGTDAVRTLSNAEDYLDDED 212 Score = 71.7 bits (174), Expect = 1e-12, Method: Composition-based stats. Identities = 32/138 (23%), Positives = 53/138 (38%), Gaps = 17/138 (12%) Query: 128 AFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKIL 187 EAA G + L+ VN L K G+TAL A GH +++++L Sbjct: 76 PLHEAAKRGNLSWLRECLDNRVGVN----------GLDKAGSTALYWACHGGHKDIVEML 125 Query: 188 LDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAV 247 + ++N + +G AL A I LLL GA ++R K +A Sbjct: 126 FTQPNIELNQQNKLGDTALHAAAW----KGYADIVQLLLAKGARTDLRNIEKKLAFDMAT 181 Query: 248 EKKHLGLVQRLLEQEHIE 265 + L +++ + Sbjct: 182 ---NAACASLLKKKQGTD 196 Score = 70.9 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 29/108 (26%), Positives = 47/108 (43%), Gaps = 12/108 (11%) Query: 95 PFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLY-KRGANVNL 153 P AA G++ L+ L VN D G TA A G ++ L+ + +N Sbjct: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135 Query: 154 RRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNM 201 + K G TAL AA KG+ +++++LL + GA + + Sbjct: 136 QNK----------LGDTALHAAAWKGYADIVQLLLAK-GARTDLRNIE 172 >2PL0-A nrPDB Length = 289 Score = 97.8 bits (242), Expect = 2e-20, Method: Composition-based stats. Identities = 60/313 (19%), Positives = 108/313 (34%), Gaps = 69/313 (22%) Query: 324 GAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGF 383 G+ P + W W + L + R + G +++G+ Sbjct: 1 GSHMQTQKPQKPWWEDE--WEVPRETLKLVER---------------LGAGQFGEVWMGY 43 Query: 384 YEKQ-EVAVKTFCEGS---PRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQ 439 Y +VAVK+ +GS E + ++ ++ LV Y + +++ E Sbjct: 44 YNGHTKVAVKSLKQGSMSPDAFLAEANLMKQL-QHQRLVRLYAVVTQEP-IYIITEYMEN 101 Query: 440 T-LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA 498 L L G + + ++ + I + + + Y H+DL+ NIL+ + Sbjct: 102 GSLVDFLKTPSGIKLTINKLL---DMAAQIAEGMAFI-EERNYIHRDLRAANILVSDTLS 157 Query: 499 AHLADFDKS-----------------IKWAG------DPQEVKRDLEDLGRLVLYVVKKG 535 +ADF + IKW +K D+ G L+ +V G Sbjct: 158 CKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHG 217 Query: 536 SISFEDLKAQSNEEVVQ--------LSPD---EETKDLIHRLFHPGEHVRDC---LSDLL 581 I + + N EV+Q + PD EE L+ + R L +L Sbjct: 218 RIPYPGMT---NPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVL 274 Query: 582 GHPFFWTWESRYR 594 FF E +Y+ Sbjct: 275 ED-FFTATEGQYQ 286 >3PVW-A nrPDB Length = 695 Score = 97.5 bits (241), Expect = 2e-20, Method: Composition-based stats. Identities = 52/338 (15%), Positives = 112/338 (33%), Gaps = 60/338 (17%) Query: 367 EKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESH 426 E Y G +Y ++ E +R + L S+ + +V + Sbjct: 204 EVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHT 263 Query: 427 RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDL 486 L + L L H + E + R + I ++ +H + ++DL Sbjct: 264 PDKLSFILDLMNGG---DLHYHLSQHGVFSEADM-RFYAAEIILGLEHMH-NRFVVYRDL 318 Query: 487 QPQNILIDSKKAAHLADFDKSIKWA---------------------GDPQEVKRDLEDLG 525 +P NIL+D ++D + ++ G + D LG Sbjct: 319 KPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLG 378 Query: 526 RLVLYVVKKGSISFEDLKAQSNEEVVQL----------SPDEETKDLIHRLFHPGEHVRD 575 +L+ + +G F K + E+ ++ S E + L+ L + R Sbjct: 379 C-MLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRL 437 Query: 576 -----CLSDLLGHPFFWTWESRYRTLR-------------NVGNESDIKT-RKSESEILR 616 ++ PFF + + + L+ N + DI + + +++ ++ Sbjct: 438 GCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIK 497 Query: 617 LLQPGP----SEHSKSFDKWTTKINECVMKKMNKFYEK 650 LL + ++W ++ E V +N ++ Sbjct: 498 LLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDR 535 >5X5O-A nrPDB Length = 310 Score = 97.5 bits (241), Expect = 2e-20, Method: Composition-based stats. Identities = 41/243 (16%), Positives = 82/243 (33%), Gaps = 41/243 (16%) Query: 372 ADTSEGGIYLGFYEKQ--EVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGH 429 S G +Y + Q EVAVK + ++E L S + +++ FYG + Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKLL----KIEKEAEIL-SVLSHRNIIQFYGVILEPPN 78 Query: 430 LFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLS--CGYTHQDLQ 487 + +L + D E + + + + K + LH+ H+DL+ Sbjct: 79 YGIVTEY--ASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLK 136 Query: 488 PQNILIDSKKAAHLADFDKSI--------KWAGD------------PQEVKRDLEDLGRL 527 +N++I + + DF S G P D G + Sbjct: 137 SRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYG-V 195 Query: 528 VLYVVKKGSISFEDLK---------AQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLS 578 VL+ + + F+ L+ ++ + S +L+H+ + R Sbjct: 196 VLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFK 255 Query: 579 DLL 581 ++ Sbjct: 256 QII 258 >3CJF-A nrPDB Length = 309 Score = 97.1 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 49/279 (17%), Positives = 89/279 (31%), Gaps = 59/279 (21%) Query: 363 FFIDEKYKIADTSEGGIYLGFYEK-----------QEVAVKTFCEGSPRAQR-----EVS 406 F ++ + G + E + VAVK EG+ ++ E+ Sbjct: 23 EFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELK 82 Query: 407 CLQSSRENSHLVTFYGS-ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEED------- 458 L + ++V G+ G L V V C+ + + + +D Sbjct: 83 ILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLT 142 Query: 459 -EFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV 517 E + K ++ L S H+DL +NIL+ K + DF + DP V Sbjct: 143 LEHLICYSFQVAKGMEFL-ASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYV 201 Query: 518 K------------------------RDLEDLGRLVLYVVKKGSISF------EDLKAQSN 547 + D+ G L+ + G+ + E+ + Sbjct: 202 RKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLK 261 Query: 548 EEVVQLSPDEETKDLIHRLF---HPGEHVRDCLSDLLGH 583 E +PD T ++ + H R S+L+ H Sbjct: 262 EGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEH 300 >3EB0-A nrPDB Length = 383 Score = 97.1 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 48/334 (14%), Positives = 90/334 (26%), Gaps = 111/334 (33%) Query: 366 DEKYKIADTSEGGIY------LGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVT 419 +KY + T G + + A+K + RE+ ++ ++ +++ Sbjct: 6 SKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKNRELDIMK-VLDHVNIIK 64 Query: 420 FYGSESHRGH--------------------------------------LFVCVTLCEQTL 441 G L V + TL Sbjct: 65 LVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDTL 124 Query: 442 EACLD--VHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK-KA 498 L + G + + +F+AV +H S G H+D++PQN+L++SK Sbjct: 125 HKVLKSFIRSGRSIPM---NLISIYIYQLFRAVGFIH-SLGICHRDIKPQNLLVNSKDNT 180 Query: 499 AHLADFDKSIK----------------------WAGDPQEVKRDLEDLGRLVLYVVKKGS 536 L DF + K DL +G + + G Sbjct: 181 LKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFG-ELILGK 239 Query: 537 ISFE---DLKAQSNEEVVQLSPDEE---------------------------------TK 560 F + + +P +E Sbjct: 240 PLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSLAI 299 Query: 561 DLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYR 594 DL+ ++ +R + + HPFF + Y Sbjct: 300 DLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYE 333 >1K9A-A nrPDB Length = 450 Score = 97.1 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 44/249 (17%), Positives = 81/249 (32%), Gaps = 41/249 (16%) Query: 370 KIADTSEGGIYLGFYEKQEVAVKTFCEGSPRA--QREVSCLQSSRENSHLVTFYGSE-SH 426 I G + LG Y +VAVK + E S + R +S+LV G Sbjct: 200 TIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLR-HSNLVQLLGVIVEE 258 Query: 427 RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDL 486 +G L++ + RG V + + +A++ L + + H+DL Sbjct: 259 KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL--KFSLDVCEAMEYLEGN-NFVHRDL 315 Query: 487 QPQNILIDSKKAAHLADFDKSIKWAGDPQ-------------------EVKRDLEDLGRL 527 +N+L+ A ++DF + + + K D+ G L Sbjct: 316 AARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGIL 375 Query: 528 VLYVVKKGSISFEDLKAQSNEEVVQ----------LSPDEETKDLIHRLFHPGEHVRDCL 577 + + G + + + + V+ P D++ +H R Sbjct: 376 LWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPA--VYDVMKNCWHLDAATRPTF 433 Query: 578 SDL---LGH 583 L L H Sbjct: 434 LQLREQLEH 442 >2XYN-A nrPDB Length = 292 Score = 97.1 bits (240), Expect = 3e-20, Method: Composition-based stats. Identities = 44/250 (17%), Positives = 85/250 (34%), Gaps = 44/250 (17%) Query: 368 KYKIADTSEGGIYLGFYEKQE--VAVKTFCEGSPRAQ---REVSCLQSSRENSHLVTFYG 422 K+K+ G +Y+G ++K VAVKT E + + +E + ++ ++ +LV G Sbjct: 37 KHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI-KHPNLVQLLG 95 Query: 423 SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYT 482 + ++ LD R + E + + I A++ L + Sbjct: 96 VCTLEPPFYIVTEYMPYG--NLLDYLRECNREEVTAVVLLYMATQISSAMEYL-EKKNFI 152 Query: 483 HQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQ-----------------------EVKR 519 H+DL +N L+ +ADF S GD +K Sbjct: 153 HRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKS 212 Query: 520 DLEDLGRLVLYVVKKGSISFEDL----------KAQSNEEVVQLSPDEETKDLIHRLFHP 569 D+ G L+ + G + + K E+ P + +L+ + Sbjct: 213 DVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP--KVYELMRACWKW 270 Query: 570 GEHVRDCLSD 579 R ++ Sbjct: 271 SPADRPSFAE 280 >6BXI-A nrPDB Length = 333 Score = 96.7 bits (239), Expect = 3e-20, Method: Composition-based stats. Identities = 48/308 (15%), Positives = 97/308 (31%), Gaps = 86/308 (27%) Query: 349 DLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCL 408 L I R G+++ + G +Y ++ ++ G RA+R++ Sbjct: 10 SLKVIGRGAFGEVRL-------VQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILV- 61 Query: 409 QSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 ++ +V + S + +L++ + L + + +E + ++ Sbjct: 62 --EADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLM----KKDTLTEEETQFYIAET 115 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWA----------------- 511 A+ +H G+ H+D++P N+L+DSK L+DF Sbjct: 116 VLAIDSIHQ-LGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPS 174 Query: 512 ----------------------------GDPQEVK------------RDLEDLGRLVLYV 531 G P + D LG +++Y Sbjct: 175 DFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLG-VIMYE 233 Query: 532 VKKGSISFEDLKAQSNEEV-----------VQLSPDEETKDLIHRLFHPGEHV--RDCLS 578 + G F Q + ++ E+ KDLI R EH + Sbjct: 234 MLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGVE 293 Query: 579 DLLGHPFF 586 ++ + FF Sbjct: 294 EIKSNSFF 301 >5TE0-A nrPDB Length = 347 Score = 96.7 bits (239), Expect = 3e-20, Method: Composition-based stats. Identities = 41/276 (14%), Positives = 87/276 (31%), Gaps = 56/276 (20%) Query: 358 IGKLKFFIDEKYKIADTSEGGIYLGFY-----EKQEVAVKTFCE----GSPRAQREVSCL 408 IG++ ++ + + G + + + A+K +RE+ + Sbjct: 10 IGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIM 69 Query: 409 QSSRENSHLVTFYGSESHR---GHLF---VCVTLCEQTLEACLDVHRGEDVENEEDEFAR 462 + + ++V + S + G ++ + + C L R + E + Sbjct: 70 RDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQ- 128 Query: 463 NVLSSIFKAVQELHL-SCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQ------ 515 + +AV LH H+DL+ +NIL+ + L DF + +PQ Sbjct: 129 -IFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNA 187 Query: 516 ---------------------------EVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNE 548 K D+ LG L LY + ++ F + + + Sbjct: 188 VEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCL-LYKLCYFTLPFGESQVAICD 246 Query: 549 EVVQLSPDEETKD----LIHRLFHPGEHVRDCLSDL 580 + + LI + P R + + Sbjct: 247 GNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQV 282 >2PMN-X nrPDB Length = 348 Score = 96.3 bits (238), Expect = 4e-20, Method: Composition-based stats. Identities = 49/302 (16%), Positives = 96/302 (31%), Gaps = 61/302 (20%) Query: 362 KFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFY 421 KF+ +KY+ E ++++K+ + + E+ + +N + +T Sbjct: 55 KFYALKKYE-KSLLEKKRDFTKSNNDKISIKSKYDDF---KNELQIITDI-KNEYCLTCE 109 Query: 422 GSESHRGHLFVCVTLCEQT----LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL 477 G ++ +++ E + V + + ++ S+ + +H Sbjct: 110 GIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHN 169 Query: 478 SCGYTHQDLQPQNILIDSKKAAHLADFDKS-----IKWAGDP-----------------Q 515 H+D++P NIL+D L+DF +S K G Sbjct: 170 EKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVDKKIKGSRGTYEFMPPEFFSNESSYN 229 Query: 516 EVKRDLEDLGRLVLYVVKKGSISFE----------DLKAQSNEEVV-------------- 551 K D+ LG LYV+ + F +++ ++ E + Sbjct: 230 GAKVDIWSLGIC-LYVMFYNVVPFSLKISLVELFNNIRTKNIEYPLDRNHFLYPLTNKKS 288 Query: 552 QLSP---DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTR 608 S E D + R D L H W ++ LR E K + Sbjct: 289 TCSNNFLSNEDIDFLKLFLRKNPAERITSEDALKHE--WLADTNIEDLREFSKELYKKRK 346 Query: 609 KS 610 K Sbjct: 347 KL 348 >2FO0-A nrPDB Length = 495 Score = 96.3 bits (238), Expect = 5e-20, Method: Composition-based stats. Identities = 44/250 (17%), Positives = 87/250 (34%), Gaps = 42/250 (16%) Query: 368 KYKIADTSEGGIYLGFYEKQE--VAVKTFCEGSPRAQ---REVSCLQSSRENSHLVTFYG 422 K+K+ G +Y G ++K VAVKT E + + +E + ++ ++ +LV G Sbjct: 222 KHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI-KHPNLVQLLG 280 Query: 423 SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYT 482 + ++ LD R + + + + I A++ L + Sbjct: 281 VCTREPPFYIITEFMTYG--NLLDYLRECNRQEVNAVVLLYMATQISSAMEYL-EKKNFI 337 Query: 483 HQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQ-----------------------EVKR 519 H++L +N L+ +ADF S GD +K Sbjct: 338 HRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKS 397 Query: 520 DLEDLGRLVLYVVKKGSIS---------FEDLKAQSNEEVVQLSPDEETKDLIHRLFHPG 570 D+ G L+ + G +E L+ E + P E+ +L+ + Sbjct: 398 DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP-EKVYELMRACWQWN 456 Query: 571 EHVRDCLSDL 580 R +++ Sbjct: 457 PSDRPSFAEI 466 >1U59-A nrPDB Length = 287 Score = 95.5 bits (236), Expect = 7e-20, Method: Composition-based stats. Identities = 40/269 (14%), Positives = 85/269 (31%), Gaps = 54/269 (20%) Query: 364 FIDEKYKIADTSEGGIYLGFYEKQ----EVAVKTFCEGSPRAQ-----REVSCLQSSREN 414 + ++ + G + G Y + +VA+K +G+ +A RE + +N Sbjct: 11 LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-DN 69 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 ++V G L + + + V + E++ +L + ++ Sbjct: 70 PYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSN---VAELLHQVSMGMKY 125 Query: 475 LHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV----------------- 517 L + H+DL +N+L+ ++ A ++DF S D Sbjct: 126 LEEK-NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 184 Query: 518 --------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHP 569 + D+ G + + G ++ +K E I + Sbjct: 185 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMK------------GPEVMAFIEQGKRM 232 Query: 570 G--EHVRDCLSDLLGHPFFWTWESRYRTL 596 L L+ + + WE R L Sbjct: 233 ECPPECPPELYALMSDCWIYKWEDRPDFL 261 >1FVR-A nrPDB Length = 327 Score = 95.5 bits (236), Expect = 8e-20, Method: Composition-based stats. Identities = 50/265 (18%), Positives = 91/265 (34%), Gaps = 53/265 (20%) Query: 368 KYKIADTSEGGIYLGFYEKQ----EVAVKTFCEGSPRAQR-----EVSCLQSSRENSHLV 418 + I + + G + +K + A+K E + + E+ L + +++ Sbjct: 30 QDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNII 89 Query: 419 TFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFAR-NVLSSIFKAVQELHL 477 G+ HRG+L++ + LD R V + FA N +S + Q LH Sbjct: 90 NLLGACEHRGYLYLAIEYAPHG--NLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 147 Query: 478 SCGY------------THQDLQPQNILIDSKKAAHLADFDKS-------IKWAGDP---- 514 + H+DL +NIL+ A +ADF S K G Sbjct: 148 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRW 207 Query: 515 ----------QEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVV--------QLSPD 556 D+ G L+ +V G + + E + L+ D Sbjct: 208 MAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCD 267 Query: 557 EETKDLIHRLFHPGEHVRDCLSDLL 581 +E DL+ + + + R + +L Sbjct: 268 DEVYDLMRQCWREKPYERPSFAQIL 292 >4UY9-A nrPDB Length = 323 Score = 95.5 bits (236), Expect = 8e-20, Method: Composition-based stats. Identities = 44/261 (16%), Positives = 85/261 (32%), Gaps = 58/261 (22%) Query: 371 IADTSEGGIYLGFYEKQEVAVKT--------FCEGSPRAQREVSCLQSSRENSHLVTFYG 422 I G +Y F+ EVAVK + ++E + ++ +++ G Sbjct: 17 IGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLF-AMLKHPNIIALRG 75 Query: 423 SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLS--CG 480 +L + + V G+ + + N I + + LH Sbjct: 76 VCLKEPNLCLVMEFARGGP--LNRVLSGKRIPP---DILVNWAVQIARGMNYLHDEAIVP 130 Query: 481 YTHQDLQPQNILI--------DSKKAAHLADFDKSIKW--------AGD-----PQEVK- 518 H+DL+ NILI S K + DF + +W AG P+ ++ Sbjct: 131 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRA 190 Query: 519 ------RDLEDLGRLVLYVVKKGSISFE-----------DLKAQSNEEVVQLSPDEETKD 561 D+ G ++L+ + G + F + + E Sbjct: 191 SMFSKGSDVWSYG-VLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCP--EPFAK 247 Query: 562 LIHRLFHPGEHVRDCLSDLLG 582 L+ ++P H R +++L Sbjct: 248 LMEDCWNPDPHSRPSFTNILD 268 >1BYG-A nrPDB Length = 278 Score = 95.2 bits (235), Expect = 1e-19, Method: Composition-based stats. Identities = 43/249 (17%), Positives = 82/249 (32%), Gaps = 41/249 (16%) Query: 370 KIADTSEGGIYLGFYEKQEVAVKTFCEGSPRA--QREVSCLQSSRENSHLVTFYGSE-SH 426 I G + LG Y +VAVK + E S + R +S+LV G Sbjct: 28 TIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLR-HSNLVQLLGVIVEE 86 Query: 427 RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDL 486 +G L++ + RG V + + +A++ L + + H+DL Sbjct: 87 KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL--KFSLDVCEAMEYLEGN-NFVHRDL 143 Query: 487 QPQNILIDSKKAAHLADFDKSIKWAGDPQ-------------------EVKRDLEDLGRL 527 +N+L+ A ++DF + + + K D+ G L Sbjct: 144 AARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGIL 203 Query: 528 VLYVVKKGSISFEDLKAQSNEEVVQ----------LSPDEETKDLIHRLFHPGEHVRDCL 577 + + G + + + + V+ P +++ +H +R Sbjct: 204 LWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPA--VYEVMKNCWHLDAAMRPSF 261 Query: 578 SDL---LGH 583 L L H Sbjct: 262 LQLREQLEH 270 >3DTC-A nrPDB Length = 271 Score = 94.8 bits (234), Expect = 1e-19, Method: Composition-based stats. Identities = 42/261 (16%), Positives = 83/261 (31%), Gaps = 58/261 (22%) Query: 371 IADTSEGGIYLGFYEKQEVAVKT--------FCEGSPRAQREVSCLQSSRENSHLVTFYG 422 I G +Y F+ EVAVK + ++E + ++ +++ G Sbjct: 15 IGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLF-AMLKHPNIIALRG 73 Query: 423 SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLS--CG 480 +L + + V G+ + + N I + + LH Sbjct: 74 VCLKEPNLCLVMEFARGGP--LNRVLSGKRIPP---DILVNWAVQIARGMNYLHDEAIVP 128 Query: 481 YTHQDLQPQNILI--------DSKKAAHLADFDKSIKWAGD-------------PQEVK- 518 H+DL+ NILI S K + DF + +W P+ ++ Sbjct: 129 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYAWMAPEVIRA 188 Query: 519 ------RDLEDLGRLVLYVVKKGSISFE-----------DLKAQSNEEVVQLSPDEETKD 561 D+ G ++L+ + G + F + + E Sbjct: 189 SMFSKGSDVWSYG-VLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCP--EPFAK 245 Query: 562 LIHRLFHPGEHVRDCLSDLLG 582 L+ ++P H R +++L Sbjct: 246 LMEDCWNPDPHSRPSFTNILD 266 >3A4O-X nrPDB Length = 286 Score = 94.4 bits (233), Expect = 1e-19, Method: Composition-based stats. Identities = 50/264 (18%), Positives = 97/264 (36%), Gaps = 45/264 (17%) Query: 370 KIADTSEGGIYLGFYEKQ-EVAVKTFCEGSPRAQR--EVSCLQSSRENSHLVTFYGSESH 426 ++ G +++G+Y +VAVKT G+ Q E + L + ++ LV Y + Sbjct: 20 RLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTR 79 Query: 427 RGHLFVCVTLCE-QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 +++ +L L G V + + + I + + + Y H+D Sbjct: 80 EEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLI---DFSAQIAEGMAYI-ERKNYIHRD 135 Query: 486 LQPQNILIDSKKAAHLADFDKS-----------------IKWAGDPQ-------EVKRDL 521 L+ N+L+ +ADF + IKW P+ +K D+ Sbjct: 136 LRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTA-PEAINFGCFTIKSDV 194 Query: 522 EDLGRLVLYVVKKGSISF------EDLKAQSNEEVVQLSPD--EETKDLIHRLFHPGEHV 573 G L+ +V G I + + + A S + + +E D++ + Sbjct: 195 WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEE 254 Query: 574 RDC---LSDLLGHPFFWTWESRYR 594 R L +L F+ E +Y+ Sbjct: 255 RPTFDYLQSVLDD-FYTATEGQYQ 277 >3SXS-A nrPDB Length = 268 Score = 94.4 bits (233), Expect = 2e-19, Method: Composition-based stats. Identities = 47/247 (19%), Positives = 81/247 (32%), Gaps = 40/247 (16%) Query: 370 KIADTSEGGIYLGFYEKQ-EVAVKTFCEGS---PRAQREVSCLQSSRENSHLVTFYGSES 425 ++ G + LG ++ Q +VAVK EGS +E + + LV FYG S Sbjct: 15 ELGSGQFGVVKLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLS-HPKLVKFYGVCS 73 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 +++ L+ R E + + + + L S + H+D Sbjct: 74 KEYPIYIVTEYISNG--CLLNYLRSHGKGLEPSQLLEMC-YDVCEGMAFL-ESHQFIHRD 129 Query: 486 LQPQNILIDSKKAAHLADFDKSI-----------------KWAGD------PQEVKRDLE 522 L +N L+D ++DF + KW+ K D+ Sbjct: 130 LAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVW 189 Query: 523 DLGRLVLYVVKKGSISFEDLKAQSNEEVV----QLSPDEETKDLIHR----LFHPGEHVR 574 G L+ V G + ++ V +L D I++ +H R Sbjct: 190 AFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKR 249 Query: 575 DCLSDLL 581 LL Sbjct: 250 PTFQQLL 256 >3PFQ-A nrPDB Length = 674 Score = 94.0 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 44/260 (16%), Positives = 80/260 (30%), Gaps = 49/260 (18%) Query: 370 KIADTSEGGIYLGFYEKQE--VAVKTFCEGSPRAQREVSCLQSSR-------ENSHLVTF 420 + S G + L + + AVK + +V C + + L Sbjct: 348 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 407 Query: 421 YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG 480 + L+ + ++ + V ++ A + I + L S G Sbjct: 408 HSCFQTMDRLYFVMEYVNGGD----LMYHIQQVGRFKEPHAVFYAAEIAIGLFFL-QSKG 462 Query: 481 YTHQDLQPQNILIDSKKAAHLADFDKSIK----------WAGDPQEV------------K 518 ++DL+ N+++DS+ +ADF + + G P + Sbjct: 463 IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 522 Query: 519 RDLEDLGRLVLYVVKKGSISFE-----DLKAQSNEEVV--QLSPDEETKDLIHRLFHPGE 571 D G ++LY + G FE +L E V S +E + L Sbjct: 523 VDWWAFG-VLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHP 581 Query: 572 HVRDCL-----SDLLGHPFF 586 R D+ H FF Sbjct: 582 GKRLGCGPEGERDIKEHAFF 601 >2I0E-A nrPDB Length = 353 Score = 94.0 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 44/260 (16%), Positives = 80/260 (30%), Gaps = 49/260 (18%) Query: 370 KIADTSEGGIYLGFYEKQE--VAVKTFCEGSPRAQREVSCLQSSR-------ENSHLVTF 420 + S G + L + + AVK + +V C + + L Sbjct: 27 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 86 Query: 421 YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG 480 + L+ + ++ + V ++ A + I + L S G Sbjct: 87 HSCFQTMDRLYFVMEYVNGGD----LMYHIQQVGRFKEPHAVFYAAEIAIGLFFL-QSKG 141 Query: 481 YTHQDLQPQNILIDSKKAAHLADFDKSIK----------WAGDPQEV------------K 518 ++DL+ N+++DS+ +ADF + + G P + Sbjct: 142 IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 201 Query: 519 RDLEDLGRLVLYVVKKGSISFE-----DLKAQSNEEVV--QLSPDEETKDLIHRLFHPGE 571 D G ++LY + G FE +L E V S +E + L Sbjct: 202 VDWWAFG-VLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHP 260 Query: 572 HVRDCL-----SDLLGHPFF 586 R D+ H FF Sbjct: 261 GKRLGCGPEGERDIKEHAFF 280 >5DND-A nrPDB Length = 588 Score = 94.0 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 39/161 (24%), Positives = 74/161 (45%), Gaps = 12/161 (7%) Query: 28 LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVL 87 L + +++ +Q L+E G+++ ++ G T LH A + R+ +V +LL G D Sbjct: 425 LALALAHAGELEALQALMELGSDL-RLKDSNGQTLLHVAARNGRDGVVTMLLHRGMDVNA 483 Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECD-FYGFTAFMEAAVYGKVKALKFLYK 146 R ++G +P +LA + ++L GA ++ D T A ++ L+ + Sbjct: 484 RDRDGLSPLLLAVQGRHRECIRLLRKAGACLSPQDLKDAGTELCRLASRADMEGLQAWGQ 543 Query: 147 RGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKIL 187 GA++ ++ G +AL A G+ EVL +L Sbjct: 544 AGADL----------QQPGYDGRSALCVAEAAGNQEVLALL 574 Score = 84.8 bits (208), Expect = 1e-16, Method: Composition-based stats. Identities = 39/160 (24%), Positives = 70/160 (43%), Gaps = 10/160 (6%) Query: 67 VQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGF 126 + ++ L+ G+D L+ NG T +AA G ++ + L +G DVN D G Sbjct: 430 AHAGELEALQALMELGSDLRLKDSNGQTLLHVAARNGRDGVVTMLLHRGMDVNARDRDGL 489 Query: 127 TAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKI 186 + + A + ++ L K GA ++ + L+ G T L A + +E L+ Sbjct: 490 SPLLLAVQGRHRECIRLLRKAGACLSPQD--------LKDAG-TELCRLASRADMEGLQA 540 Query: 187 LLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLL 226 + GAD+ GR+AL A + + + + +L L Sbjct: 541 -WGQAGADLQQPGYDGRSALCVAEAAGNQEVLALLRNLAL 579 Score = 79.0 bits (193), Expect = 8e-15, Method: Composition-based stats. Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 7/125 (5%) Query: 176 AEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVR 235 A G +E L+ L+ E+G+D+ D+ G+ L A + D + +LL G DVN R Sbjct: 430 AHAGELEALQALM-ELGSDLRLKDSNGQTLLHVAARNGRDG----VVTMLLHRGMDVNAR 484 Query: 236 GERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTD-SDGKTALLLAVELKLKKIAELLCK 294 G +PL+LAV+ +H + RLL + ++ D D T L + + + Sbjct: 485 DRDGLSPLLLAVQGRHRECI-RLLRKAGACLSPQDLKDAGTELCRLASRADMEGLQAWGQ 543 Query: 295 RGAST 299 GA Sbjct: 544 AGADL 548 Score = 72.4 bits (176), Expect = 6e-13, Method: Composition-based stats. Identities = 34/132 (25%), Positives = 56/132 (42%), Gaps = 3/132 (2%) Query: 14 TSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSRED 73 S + LL A +N +V LL G +VN ++ +G +PL AVQ + Sbjct: 445 GSDLRLK-DSNGQTLLHVAARNGRDGVVTMLLHRGMDVNARDRDG-LSPLLLAVQGRHRE 502 Query: 74 IVELLLRHGADPVLRK-KNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEA 132 + LL + GA + K+ T A ++ L+ + GAD+ + + G +A A Sbjct: 503 CIRLLRKAGACLSPQDLKDAGTELCRLASRADMEGLQAWGQAGADLQQPGYDGRSALCVA 562 Query: 133 AVYGKVKALKFL 144 G + L L Sbjct: 563 EAAGNQEVLALL 574 Score = 52.4 bits (124), Expect = 7e-07, Method: Composition-based stats. Identities = 36/178 (20%), Positives = 61/178 (34%), Gaps = 23/178 (12%) Query: 197 ACDNMGRNAL----IHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTP-LILA-VEKK 250 A D G L +H + + + L G + P L LA Sbjct: 374 AKDLRGEMTLPTADLHQSSPPGSTLGQGVARLFSLFGCQEEDSVQDAVMPSLALALAHAG 433 Query: 251 HLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDL-----V 305 L +Q L+E ++ DS+G+T L +A + +L RG + D + Sbjct: 434 ELEALQALME-LGSDLRLKDSNGQTLLHVAARNGRDGVVTMLLHRGMDVNARDRDGLSPL 492 Query: 306 MTARRNYDHSLVKVLLSHGA---KEDFHPPAEDWKPQSSH--------WGAALKDLHR 352 + A + +++L GA +D + +S WG A DL + Sbjct: 493 LLAVQGRHRECIRLLRKAGACLSPQDLKDAGTELCRLASRADMEGLQAWGQAGADLQQ 550 >3OMV-A nrPDB Length = 307 Score = 94.0 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 42/258 (16%), Positives = 89/258 (34%), Gaps = 54/258 (20%) Query: 370 KIADTSEGGIYLGFYEKQEVAVKTF------CEGSPRAQREVSCLQSSRENSHLVTFYGS 423 +I S G +Y G + +VAVK E + EV+ L+ +R + +++ F G Sbjct: 43 RIGSGSFGTVYKGKWHG-DVAVKILKVVDPTPEQFQAFRNEVAVLRKTR-HVNILLFMG- 99 Query: 424 ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTH 483 + +L + CE + + ++ + + + ++ + + LH H Sbjct: 100 YMTKDNLAIVTQWCEGS--SLYKHLHVQETKFQMFQL-IDIARQTAQGMDYLHAK-NIIH 155 Query: 484 QDLQPQNILIDSKKAAHLADFDKSI---KWAG------------------------DPQE 516 +D++ NI + + DF + +W+G +P Sbjct: 156 RDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFS 215 Query: 517 VKRDLEDLGRLVLYVVKKGSISFEDLKAQ--------SNEEVVQLSP-----DEETKDLI 563 + D+ G +VLY + G + + + + LS + K L+ Sbjct: 216 FQSDVYSYG-IVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLV 274 Query: 564 HRLFHPGEHVRDCLSDLL 581 + R +L Sbjct: 275 ADCVKKVKEERPLFPQIL 292 >5H2U-A nrPDB Length = 267 Score = 93.6 bits (231), Expect = 3e-19, Method: Composition-based stats. Identities = 38/248 (15%), Positives = 78/248 (31%), Gaps = 43/248 (17%) Query: 370 KIADTSEGGIYLGFYEKQ-EVAVKTFCEGS----PRAQREVSCLQSSRENSHLVTFYGSE 424 K+ G ++ G ++ + +VA+K + Q E+ ++ R + H++ Y Sbjct: 13 KLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLR-HKHILALYAVV 71 Query: 425 SHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQ 484 S +++ L + L E V + ++ + + + L S Y H+ Sbjct: 72 SVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELL--DIAWQVAEGMCYL-ESQNYIHR 128 Query: 485 DLQPQNILIDSKKAAHLADFDKS----------------IKWAG------DPQEVKRDLE 522 DL +NIL+ + DF + KW K D+ Sbjct: 129 DLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVW 188 Query: 523 DLGRLVLYVVKKGSISFEDLKAQ----------SNEEVVQLSPDEETKDLIHRLFHPGEH 572 G L+ + +G + + + ++ P L + Sbjct: 189 SFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLT--CWCRDPE 246 Query: 573 VRDCLSDL 580 R L Sbjct: 247 QRPTFKAL 254 >4E93-A nrPDB Length = 377 Score = 93.6 bits (231), Expect = 3e-19, Method: Composition-based stats. Identities = 44/254 (17%), Positives = 84/254 (33%), Gaps = 52/254 (20%) Query: 370 KIADTSEGGIYLGFYEKQE--VAVKTFCEGSP-----RAQREVSCLQSSRENSHLVTFYG 422 +I + G ++ G VAVK+ E P + +E L+ + ++V G Sbjct: 121 QIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYS-HPNIVRLIG 179 Query: 423 SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFK---AVQELHLSC 479 + + +++ + L + L R E + +L + ++ L C Sbjct: 180 VCTQKQPIYIVMELVQGG--DFLTFLRTEGARLR----VKTLLQMVGDAAAGMEYLESKC 233 Query: 480 GYTHQDLQPQNILIDSKKAAHLADFDKSI------------------KWAG------DPQ 515 H+DL +N L+ K ++DF S KW Sbjct: 234 -CIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRY 292 Query: 516 EVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEV---------VQLSPDEETKDLIHRL 566 + D+ G L+ G+ + +L Q E +L PD + L+ + Sbjct: 293 SSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFR-LMEQC 351 Query: 567 FHPGEHVRDCLSDL 580 + R S + Sbjct: 352 WAYEPGQRPSFSTI 365 >3KUL-B nrPDB Length = 325 Score = 92.8 bits (229), Expect = 4e-19, Method: Composition-based stats. Identities = 46/255 (18%), Positives = 81/255 (31%), Gaps = 50/255 (19%) Query: 371 IADTSEGGIYLGF-----YEKQEVAVKTFCEGSPRAQR-----EVSCLQSSRENSHLVTF 420 I G + G VA+K G QR E S + ++ +++ Sbjct: 57 IGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQF-DHPNIIRL 115 Query: 421 YGSESHRGHLFVCVTLCEQT-LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSC 479 G + + E L+ L H G+ + L + ++ L Sbjct: 116 EGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGM----LRGVGAGMRYL-SDL 170 Query: 480 GYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQ------------------------ 515 GY H+DL +N+L+DS ++DF S DP Sbjct: 171 GYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRT 230 Query: 516 -EVKRDLEDLGRLVLYVVKKGSISFEDLKAQ----SNEEVVQLSPDEETKDLIHRLF--- 567 D+ G ++ V+ G + ++ + S EE +L +H+L Sbjct: 231 FSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDC 290 Query: 568 -HPGEHVRDCLSDLL 581 H R S ++ Sbjct: 291 WHKDRAQRPRFSQIV 305 >2DQ7-X nrPDB Length = 283 Score = 92.5 bits (228), Expect = 5e-19, Method: Composition-based stats. Identities = 47/263 (17%), Positives = 93/263 (35%), Gaps = 44/263 (16%) Query: 370 KIADTSEGGIYLGFYE-KQEVAVKTFCEG--SPRAQREVSCLQSSRENSHLVTFYGSESH 426 ++ + G +++G + +VA+KT G SP + E + + ++ LV Y S Sbjct: 16 RLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSE 75 Query: 427 RGHLFVCVTLCE-QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 +++ +L L G ++ ++ + + + + Y H+D Sbjct: 76 EP-IYIVTEYMNKGSLLDFLKDGEGRALKLPNLV---DMAAQVAAGMAYI-ERMNYIHRD 130 Query: 486 LQPQNILIDSKKAAHLADFDKS-----------------IKWAG------DPQEVKRDLE 522 L+ NIL+ + +ADF + IKW +K D+ Sbjct: 131 LRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 190 Query: 523 DLGRLVLYVVKKGSISF------EDLKAQSNEEVVQLSPD--EETKDLIHRLFHPGEHVR 574 G L+ +V KG + + E L+ + D +L+ + R Sbjct: 191 SFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEER 250 Query: 575 DC---LSDLLGHPFFWTWESRYR 594 L L +F E +Y+ Sbjct: 251 PTFEYLQSFLED-YFTATEPQYQ 272 >3N9X-A nrPDB Length = 432 Score = 92.5 bits (228), Expect = 6e-19, Method: Composition-based stats. Identities = 29/155 (18%), Positives = 60/155 (38%), Gaps = 20/155 (12%) Query: 368 KYKIADTSEGGIYLG--FYEKQEVAVKTF------CEGSPRAQREVSCLQSSRENSHLVT 419 K+ I S G +YL ++ VA+K R RE++ L ++ +++ Sbjct: 31 KHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRL-KSDYIIR 89 Query: 420 FYGSESHRG-----HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 Y L++ + + + L+ +E + +L ++ Sbjct: 90 LYDLIIPDDLLKFDELYIVLEIADSDLKKLFKTPIFL-----TEEHIKTILYNLLLGENF 144 Query: 475 LHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK 509 +H S G H+DL+P N L++ + + DF + Sbjct: 145 IHES-GIIHRDLKPANCLLNQDCSVKVCDFGLART 178 Score = 33.5 bits (75), Expect = 0.36, Method: Composition-based stats. Identities = 16/89 (17%), Positives = 33/89 (37%), Gaps = 19/89 (21%) Query: 534 KGSISFEDLKAQSNEEVVQL-----------------SPDEETKDLIHRLFHPGEHVRDC 576 G+ + +DLK + EV++ S ++ +L+ + + R Sbjct: 296 IGTPTEDDLKNINKPEVIKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRIT 355 Query: 577 LSDLLGHPFFWTWESRYRTLRNVGNESDI 605 + L HP+ + R + L N + I Sbjct: 356 IDQALDHPY--LKDVRKKKLENFSTKKII 382 >2OZO-A nrPDB Length = 613 Score = 92.5 bits (228), Expect = 6e-19, Method: Composition-based stats. Identities = 39/269 (14%), Positives = 85/269 (31%), Gaps = 54/269 (20%) Query: 364 FIDEKYKIADTSEGGIYLGFYEKQ----EVAVKTFCEGSPRAQ-----REVSCLQSSREN 414 + ++ + G + G Y + +VA+K +G+ +A RE + +N Sbjct: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-DN 395 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 ++V G L + + + V + E++ +L + ++ Sbjct: 396 PYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSN---VAELLHQVSMGMKY 451 Query: 475 LHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV----------------- 517 L + H++L +N+L+ ++ A ++DF S D Sbjct: 452 LEEK-NFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 Query: 518 --------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHP 569 + D+ G + + G ++ +K E I + Sbjct: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMK------------GPEVMAFIEQGKRM 558 Query: 570 G--EHVRDCLSDLLGHPFFWTWESRYRTL 596 L L+ + + WE R L Sbjct: 559 ECPPECPPELYALMSDCWIYKWEDRPDFL 587 >2R2P-A nrPDB Length = 295 Score = 92.5 bits (228), Expect = 6e-19, Method: Composition-based stats. Identities = 46/262 (17%), Positives = 85/262 (32%), Gaps = 48/262 (18%) Query: 364 FIDEKYKIADTSEGGIYLGFYE-----KQEVAVKTFCEGSPRAQR-----EVSCLQSSRE 413 I + I G + G + + VA+KT G QR E S + + Sbjct: 23 CITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQF-D 81 Query: 414 NSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQ 473 + +++ G + + + E LD ++ +L I ++ Sbjct: 82 HPNIIHLEGVVTKSKPVMIVTEYMENGS---LDTFLKKNDGQFTVIQLVGMLRGISAGMK 138 Query: 474 ELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQ------------------ 515 L GY H+DL +NILI+S ++DF S DP+ Sbjct: 139 YL-SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPE 197 Query: 516 -------EVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQL-----SPDEETKDLI 563 D+ G ++ VV G + ++ Q + V+ SP + L Sbjct: 198 AIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALY 257 Query: 564 HRLFH---PGEHVRDCLSDLLG 582 + + R +++ Sbjct: 258 QLMLDCWQKERNSRPKFDEIVN 279 >4UYA-A nrPDB Length = 340 Score = 92.1 bits (227), Expect = 9e-19, Method: Composition-based stats. Identities = 43/263 (16%), Positives = 83/263 (31%), Gaps = 56/263 (21%) Query: 368 KYKIADTSEGGIYLGFYEKQEVAVKTFCEG--------SPRAQREVSCLQSSRENSHLVT 419 K I G +Y ++ QEVAVK + + +RE R + +++ Sbjct: 31 KELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLR-HPNIIE 89 Query: 420 FYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLS- 478 G + HL + + A G + I + + LH Sbjct: 90 LRGVCLQQPHLCLVLEFARGG--ALNRALAGRRIPPHVLVNW---AVQIARGMLYLHEEA 144 Query: 479 -CGYTHQDLQPQNILIDS--------KKAAHLADFDKSIKWAGD-------------PQE 516 H+DL+ NIL+ K + DF + +W P+ Sbjct: 145 FVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAYAWMAPEV 204 Query: 517 VK-------RDLEDLGRLVLYVVKKGSISFEDLK----------AQSNEEVVQLSPDEET 559 +K D+ G ++L+ + G + + + + + P+ Sbjct: 205 IKSSLFSKGSDIWSYG-VLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFA 263 Query: 560 KDLIHRLFHPGEHVRDCLSDLLG 582 K L+ + H+R + +L Sbjct: 264 K-LMKECWQQDPHIRPSFALILE 285 >3DKO-A nrPDB Length = 318 Score = 91.7 bits (226), Expect = 9e-19, Method: Composition-based stats. Identities = 53/263 (20%), Positives = 93/263 (35%), Gaps = 50/263 (19%) Query: 364 FIDEKYKIADTSEGGIYLGFYE---KQEVA--VKTFCEGSPRAQR-----EVSCLQSSRE 413 I + I G + G + K++VA +KT G QR E S + + Sbjct: 44 CIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQF-D 102 Query: 414 NSHLVTFYGSESHRGHLFVCVTLCEQT-LEACLDVHRGEDVENEEDEFARNVLSSIFKAV 472 + ++V G + + + + E L+A L H G+ + L I + Sbjct: 103 HPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGM----LRGIAAGM 158 Query: 473 QELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV--------------- 517 + L GY H+DL +NIL++S ++DF S DP+ V Sbjct: 159 RYL-ADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAP 217 Query: 518 ----------KRDLEDLGRLVLYVVKKGSISFEDLKAQ----SNEEVVQLSPDEETKDLI 563 D+ G ++ V+ G + D+ Q + EE +L + + Sbjct: 218 EAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGL 277 Query: 564 HRLF----HPGEHVRDCLSDLLG 582 H+L R ++G Sbjct: 278 HQLMLDCWQKERAERPKFEQIVG 300 >5AMN-A nrPDB Length = 299 Score = 91.7 bits (226), Expect = 1e-18, Method: Composition-based stats. Identities = 54/288 (18%), Positives = 88/288 (30%), Gaps = 65/288 (22%) Query: 358 IGKLKFFIDEKYK-------IADTSEGGIYLGFYEKQ-----------EVAVKTFCE-GS 398 + K D K++ + T G + + VAVK E S Sbjct: 7 VDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENAS 66 Query: 399 PRAQR----EVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVE 454 P R E + L+ + H++ YG+ S G L + V + + Sbjct: 67 PSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGP 125 Query: 455 NEEDEFA------RNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI 508 DE A + I + +Q L H+DL +NIL+ + ++DF S Sbjct: 126 GYPDERALTMGDLISFAWQISQGMQYL-AEMKLVHRDLAARNILVAEGRKMKISDFGLSR 184 Query: 509 KWAGDPQEVKR------------------------DLEDLGRLVLYVVKKGSIS------ 538 + VKR D+ G L+ +V G Sbjct: 185 DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP 244 Query: 539 ---FEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGH 583 F LK E + EE L+ + + R +D+ Sbjct: 245 ERLFNLLKTGHRMERPD-NCSEEMYRLMLQCWKQEPDKRPVFADISKD 291 >5L6P-A nrPDB Length = 298 Score = 91.7 bits (226), Expect = 1e-18, Method: Composition-based stats. Identities = 45/264 (17%), Positives = 87/264 (32%), Gaps = 50/264 (18%) Query: 364 FIDEKYKIADTSEGGIYLGFYEKQE-----VAVKTFCEGSPRAQR-----EVSCLQSSRE 413 + + I G + G ++ VA+KT G QR E S + + Sbjct: 20 CVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQF-D 78 Query: 414 NSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQ 473 + +++ G + + + E LD + +L I ++ Sbjct: 79 HPNIIRLEGVVTKSRPVMILTEFMENCA---LDSFLRLNDGQFTVIQLVGMLRGIAAGMK 135 Query: 474 ELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE----------------- 516 L Y H+DL +NIL++S ++DF S DP + Sbjct: 136 YL-SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTA 194 Query: 517 ----------VKRDLEDLGRLVLYVVKKGSISFEDLKAQ----SNEEVVQLSPDEETKDL 562 D+ G ++ V+ G + D+ Q + E+ +L P + Sbjct: 195 PEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTA 254 Query: 563 IHRLF----HPGEHVRDCLSDLLG 582 +H+L ++R S ++ Sbjct: 255 LHQLMLDCWVRDRNLRPKFSQIVN 278 >5IKW-A nrPDB Length = 310 Score = 91.7 bits (226), Expect = 1e-18, Method: Composition-based stats. Identities = 33/222 (14%), Positives = 71/222 (31%), Gaps = 46/222 (20%) Query: 402 QREVSCLQSSRENSHLVTFYG--SESHRGHLF---VCVTLCEQTLEACLDVHRGEDVENE 456 +RE++ ++ + ++V + S +++ + + C + + E Sbjct: 58 KREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTE 117 Query: 457 EDEFARNVLSSIFKAVQELHL-SCGYTHQDLQPQNILIDSKKAAHLADFDKSIK------ 509 + + +AV LH H+DL+ +NIL++ L DF + Sbjct: 118 PEVLQ--IFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQ 175 Query: 510 ---------------------------WAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDL 542 + G P K D+ LG L LY + ++ F + Sbjct: 176 KDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCL-LYKLCFFTLPFGES 234 Query: 543 KAQSNEEVVQLSPDEETKD----LIHRLFHPGEHVRDCLSDL 580 + + + + LI + P R + + Sbjct: 235 QVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQV 276 >1JPA-A nrPDB Length = 312 Score = 91.3 bits (225), Expect = 1e-18, Method: Composition-based stats. Identities = 47/280 (16%), Positives = 90/280 (32%), Gaps = 51/280 (18%) Query: 349 DLHRIYRPMIGKLKF-FIDEKYKIADTSEGGIYLGFYE---KQE--VAVKTFCEGSPRAQ 402 D + R ++ + + I G + G + K+E VA+KT G Q Sbjct: 18 DPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQ 77 Query: 403 R-----EVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEE 457 R E S + ++ +++ G + + + E LD ++ Sbjct: 78 RRDFLSEASIMGQF-DHPNVIHLEGVVTKSTPVMIITEFMENGS---LDSFLRQNDGQFT 133 Query: 458 DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI---KWAGDP 514 +L I ++ L Y H+DL +NIL++S ++DF S DP Sbjct: 134 VIQLVGMLRGIAAGMKYL-ADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDP 192 Query: 515 QEVK------------------------RDLEDLGRLVLYVVKKGSISFEDLKAQSNEEV 550 D+ G ++ V+ G + D+ Q Sbjct: 193 TYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINA 252 Query: 551 VQ----LSPDEETKDLIHRLF----HPGEHVRDCLSDLLG 582 ++ L P + +H+L + R ++ Sbjct: 253 IEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVN 292 >3NIE-A nrPDB Length = 429 Score = 90.9 bits (224), Expect = 2e-18, Method: Composition-based stats. Identities = 28/160 (17%), Positives = 63/160 (39%), Gaps = 20/160 (12%) Query: 368 KYKIADTSEGGIYLGFYEK--QEVAVKTF------CEGSPRAQREVSCLQSSRENSHLVT 419 K+ I S G +YL + + + VA+K R RE++ L ++ +++ Sbjct: 33 KHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRL-KSDYIIR 91 Query: 420 FYGSESHRG-----HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 + L++ + + + L+ ++ + +L ++ + Sbjct: 92 LHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIFL-----TEQHVKTILYNLLLGEKF 146 Query: 475 LHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDP 514 +H S G H+DL+P N L++ + + DF + D Sbjct: 147 IHES-GIIHRDLKPANCLLNQDCSVKICDFGLARTINSDK 185 Score = 35.8 bits (81), Expect = 0.067, Method: Composition-based stats. Identities = 20/89 (22%), Positives = 31/89 (34%), Gaps = 19/89 (21%) Query: 534 KGSISFEDLKAQSNEEVVQL-----------------SPDEETKDLIHRLFHPGEHVRDC 576 G+ EDLK + +EV++ S +E DL+ + R Sbjct: 301 IGTPPEEDLKCITKQEVIKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRIT 360 Query: 577 LSDLLGHPFFWTWESRYRTLRNVGNESDI 605 + L HP+ + R L N E I Sbjct: 361 IDKALSHPY--LKDVRKENLENFSTEKII 387 >3QGY-A nrPDB Length = 286 Score = 90.9 bits (224), Expect = 2e-18, Method: Composition-based stats. Identities = 51/274 (18%), Positives = 90/274 (32%), Gaps = 48/274 (17%) Query: 345 AALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQE-VAVKTFCEGS---PR 400 LH + P +L F +I G ++LG++ ++ VA+KT EGS Sbjct: 15 VPRGSLHMVIDP--SELTFVQ----EIGSGQFGLVHLGYWLNKDKVAIKTIKEGSMSEDD 68 Query: 401 AQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEF 460 E + + LV YG + + + E D R + + Sbjct: 69 FIEEAEVMMKLS-HPKLVQLYGVCLEQAPICLVFEFMEHG--CLSDYLRTQRGLFAAETL 125 Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI------------ 508 L + + + L +C H+DL +N L+ + ++DF + Sbjct: 126 LGMCL-DVCEGMAYLEEAC-VIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTG 183 Query: 509 -----KWAG------DPQEVKRDLEDLGRLVLYVVKKGSISF---------EDLKAQSNE 548 KWA K D+ G L+ V +G I + ED+ Sbjct: 184 TKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRL 243 Query: 549 EVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLG 582 +L+ +++ + R S LL Sbjct: 244 YKPRLA-STHVYQIMNHCWKERPEDRPAFSRLLR 276 >4P5Q-A nrPDB Length = 361 Score = 90.9 bits (224), Expect = 2e-18, Method: Composition-based stats. Identities = 41/260 (15%), Positives = 80/260 (30%), Gaps = 54/260 (20%) Query: 368 KYKIADTSEGGIYLGFYE-----KQEVAVKTFCEGSPRAQR-----EVSCLQSSRENSHL 417 + G + G + + VA+KT G QR E S + ++ ++ Sbjct: 38 DKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQF-DHPNI 96 Query: 418 VTFYGSESHRGHLFVCVTLCEQT-LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 + G + + + E L++ L H + + L I ++ L Sbjct: 97 IRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGM----LRGIASGMKYL- 151 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQ--------------------- 515 GY H+DL +NILI+S ++DF S DP+ Sbjct: 152 SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIA 211 Query: 516 ----EVKRDLEDLGRLVLYVVKKGSISFEDLKAQ----------SNEEVVQLSPDEETKD 561 D+ G ++ V+ G + ++ Q + Sbjct: 212 YRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCP--AALYQ 269 Query: 562 LIHRLFHPGEHVRDCLSDLL 581 L+ + + R ++ Sbjct: 270 LMLDCWQKDRNNRPKFEQIV 289 >5FM2-A nrPDB Length = 355 Score = 90.5 bits (223), Expect = 2e-18, Method: Composition-based stats. Identities = 65/336 (19%), Positives = 105/336 (31%), Gaps = 80/336 (23%) Query: 325 AKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPM-IGKLKFFIDEKYK-------IADTSE 376 A+ F PA+ + S GA L + + + K D K++ + T Sbjct: 14 AEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLG 73 Query: 377 GGIYLGFYEKQ-----------EVAVKTFCE-GSPRAQR----EVSCLQSSRENSHLVTF 420 G + + VAVK E SP R E + L+ + H++ Sbjct: 74 EGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV-NHPHVIKL 132 Query: 421 YGSESHRGHLFVCVTLCE-QTLEACLDVHRG-------------EDVENEEDEFA----- 461 YG+ S G L + V + +L L R + DE A Sbjct: 133 YGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGD 192 Query: 462 -RNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKR- 519 + I + +Q L H+DL +NIL+ + ++DF S + VKR Sbjct: 193 LISFAWQISQGMQYL-AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRS 251 Query: 520 -----------------------DLEDLGRLVLYVVKKGSIS---------FEDLKAQSN 547 D+ G L+ +V G F LK Sbjct: 252 QGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHR 311 Query: 548 EEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGH 583 E + EE L+ + + R +D+ Sbjct: 312 MERPD-NCSEEMYRLMLQCWKQEPDKRPVFADISKD 346 >4YFF-A nrPDB Length = 311 Score = 90.1 bits (222), Expect = 3e-18, Method: Composition-based stats. Identities = 47/252 (18%), Positives = 84/252 (33%), Gaps = 45/252 (17%) Query: 371 IADTSEGGIYLGFYEKQEVAVKTFC-------EGSPRAQREVSCLQSSRENSHLVTFYGS 423 I S G +Y G + VA+K + REVS L + ++ F G+ Sbjct: 50 IGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSIL-CQLNHPCVIQFVGA 108 Query: 424 ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH-LSCGYT 482 + F VT +H + + + + + + + K ++ LH L+ Sbjct: 109 CLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKL--IIAVDVAKGMEYLHNLTQPII 166 Query: 483 HQDLQPQNILIDSKKAAHLADFDKSIKW------------------------AGDPQEVK 518 H+DL NIL+ A +ADF +S +K Sbjct: 167 HRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIK 226 Query: 519 RDLEDLGRLVLYVVKKGSISFEDLKAQSNE---------EVVQLSPDEETKDLIHRLFHP 569 D+ L+ + G I F LK + + S + L+ R ++ Sbjct: 227 ADVFSYALC-LWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNA 285 Query: 570 GEHVRDCLSDLL 581 R S+++ Sbjct: 286 CPEGRPEFSEVV 297 >5GNK-A nrPDB Length = 297 Score = 89.8 bits (221), Expect = 4e-18, Method: Composition-based stats. Identities = 50/293 (17%), Positives = 103/293 (35%), Gaps = 53/293 (18%) Query: 355 RPMIGKLKFFIDEKYKI-ADTSEGGIYLGFYEKQ------EVAVKTFCE-GSPRAQREV- 405 + ++ LK +K K+ + G +Y G + + VA+K E SP+A +E+ Sbjct: 10 QALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEIL 69 Query: 406 --SCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARN 463 + + +S +N H+ G + + + L CL + E +N ++ N Sbjct: 70 DEAYVMASVDNPHVCRLLGICLT-STVQLIMQLMPFG---CLLDYVREHKDNIGSQYLLN 125 Query: 464 VLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV------ 517 I K + L H+DL +N+L+ + + + DF + + +E Sbjct: 126 WCVQIAKGMNYL-EDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGK 184 Query: 518 ------------------KRDLEDLGRLVLYVVKKGSISFEDL----------KAQSNEE 549 + D+ G V ++ GS ++ + K + + Sbjct: 185 VPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQ 244 Query: 550 VVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNE 602 + D ++ + + R +L+ F R L G+E Sbjct: 245 PPICTID--VYMIMVKCWMIDADSRPKFRELII-EFSKMARDPQRYLVIQGDE 294 >2PSQ-A nrPDB Length = 370 Score = 89.4 bits (220), Expect = 5e-18, Method: Composition-based stats. Identities = 40/284 (14%), Positives = 81/284 (28%), Gaps = 65/284 (22%) Query: 363 FFIDEKYKIADTSEGGIYLGFYEKQ-------------EVAVKTFCEGSPRAQ-----RE 404 F +K + G + + VAVK + + E Sbjct: 77 EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 136 Query: 405 VSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQT-LEACLDVHRGE--------DVEN 455 + ++ ++ +++ G+ + G L+V V + L L R + Sbjct: 137 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVP 196 Query: 456 EEDEFAR---NVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAG 512 EE + + + + ++ L S H+DL +N+L+ +ADF + Sbjct: 197 EEQMTFKDLVSCTYQLARGMEYL-ASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN 255 Query: 513 DPQEVK------------------------RDLEDLGRLVLYVVKKGSIS---------F 539 K D+ G L+ + G F Sbjct: 256 IDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 315 Query: 540 EDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGH 583 + LK + + E ++ +H R L+ Sbjct: 316 KLLKEGHRMDKPA-NCTNELYMMMRDCWHAVPSQRPTFKQLVED 358 >3RP9-A nrPDB Length = 458 Score = 89.4 bits (220), Expect = 6e-18, Method: Composition-based stats. Identities = 31/162 (19%), Positives = 60/162 (37%), Gaps = 24/162 (14%) Query: 365 IDEKYKIADTSEGGIYLGF------YEKQEVAVKTFCE------GSPRAQREVSCLQSSR 412 I ++Y+I G Y EK+ VA+K R RE++ L Sbjct: 51 IPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRL- 109 Query: 413 ENSHLVTFYGSESHRG-----HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSS 467 + H+V + L+V + + + + + + +L + Sbjct: 110 NHDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLF-----RTPVYLTELHIKTLLYN 164 Query: 468 IFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK 509 + V+ +H S G H+DL+P N L++ + + DF + Sbjct: 165 LLVGVKYVH-SAGILHRDLKPANCLVNQDCSVKVCDFGLART 205 Score = 37.4 bits (85), Expect = 0.026, Method: Composition-based stats. Identities = 8/33 (24%), Positives = 16/33 (48%) Query: 554 SPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + + L+ R+ + R +++ L HPFF Sbjct: 368 ASSADAIHLLKRMLVFNPNKRITINECLAHPFF 400 >6E4F-A nrPDB Length = 290 Score = 89.0 bits (219), Expect = 7e-18, Method: Composition-based stats. Identities = 45/249 (18%), Positives = 86/249 (34%), Gaps = 40/249 (16%) Query: 370 KIADTSEGGIYLGFYEKQ-EVAVKTFCEGS---PRAQREVSCLQSSRENSHLVTFYGSES 425 ++ G + G + Q +VA+K EGS E + + + LV YG + Sbjct: 38 ELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLS-HEKLVQLYGVCT 96 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 + +F+ CL + E + + + + +A++ L S + H+D Sbjct: 97 KQRPIFIITEYMANG---CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL-ESKQFLHRD 152 Query: 486 LQPQNILIDSKKAAHLADFDKSIKWAGD---------------PQEV--------KRDLE 522 L +N L++ + ++DF S D P EV K D+ Sbjct: 153 LAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIW 212 Query: 523 DLGRLVLYVVKKGSISFEDLKAQSNEEVVQLS--------PDEETKDLIHRLFHPGEHVR 574 G L+ + G + +E E + E+ +++ +H R Sbjct: 213 AFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADER 272 Query: 575 DCLSDLLGH 583 LL + Sbjct: 273 PTFKILLSN 281 >4XI2-A nrPDB Length = 446 Score = 89.0 bits (219), Expect = 7e-18, Method: Composition-based stats. Identities = 45/249 (18%), Positives = 85/249 (34%), Gaps = 40/249 (16%) Query: 370 KIADTSEGGIYLGFYEKQ-EVAVKTFCEGS---PRAQREVSCLQSSRENSHLVTFYGSES 425 ++ G + G + Q +VA+K EGS E + + + LV YG + Sbjct: 194 ELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLS-HEKLVQLYGVCT 252 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 + +F+ CL + E + + + + +A++ L S + H+D Sbjct: 253 KQRPIFIITEYMANG---CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL-ESKQFLHRD 308 Query: 486 LQPQNILIDSKKAAHLADFDKSIKWAGD---------------PQEV--------KRDLE 522 L +N L++ + ++DF S D P EV K D+ Sbjct: 309 LAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIW 368 Query: 523 DLGRLVLYVVKKGSISFEDLKAQSNEEVVQLS--------PDEETKDLIHRLFHPGEHVR 574 G L+ + G + +E E + E +++ +H R Sbjct: 369 AFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADER 428 Query: 575 DCLSDLLGH 583 LL + Sbjct: 429 PSFKILLSN 437 >4PDO-A nrPDB Length = 299 Score = 89.0 bits (219), Expect = 7e-18, Method: Composition-based stats. Identities = 45/262 (17%), Positives = 83/262 (31%), Gaps = 49/262 (18%) Query: 364 FIDEKYKIADTSEGGIYLGFYEKQ------EVAVKTFCEGSPRAQR-----EVSCLQSSR 412 + + I G +Y G + VA+KT G QR E + Sbjct: 35 CVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFS 94 Query: 413 ENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAV 472 + +++ G S + + E LD E +L I + Sbjct: 95 HH-NIIRLEGVISKYKPMMIITEYMENGA---LDKFLREKDGEFSVLQLVGMLRGIAAGM 150 Query: 473 QELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQ----------------- 515 + L + Y H+DL +NIL++S ++DF S DP+ Sbjct: 151 KYL-ANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAP 209 Query: 516 --------EVKRDLEDLGRLVLYVVKKGSISFEDL------KAQSNEEVVQLSPD--EET 559 D+ G ++ V+ G + +L KA ++ + D Sbjct: 210 EAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAI 269 Query: 560 KDLIHRLFHPGEHVRDCLSDLL 581 L+ + + R +D++ Sbjct: 270 YQLMMQCWQQERARRPKFADIV 291 >4AT3-A nrPDB Length = 299 Score = 89.0 bits (219), Expect = 8e-18, Method: Composition-based stats. Identities = 50/268 (18%), Positives = 90/268 (33%), Gaps = 60/268 (22%) Query: 368 KYKIADTSEGGIYLGF-------YEKQEVAVKTFCEGSPRAQ----REVSCLQSSRENSH 416 K ++ + + G ++L +K VAVKT + S A+ RE L + ++ H Sbjct: 18 KRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNL-QHEH 76 Query: 417 LVTFYGSESHRGHLFVCVTLC-EQTLEACLDVHRGEDV----ENEEDEFAR----NVLSS 467 +V FYG L + L L H + V N E + ++ Sbjct: 77 IVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQ 136 Query: 468 IFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE----------- 516 I + L S + H+DL +N L+ + DF S Sbjct: 137 IAAGMVYL-ASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIR 195 Query: 517 -------------VKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQL---------- 553 + D+ LG ++ + G + L SN EV++ Sbjct: 196 WMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQL---SNNEVIECITQGRVLQRP 252 Query: 554 -SPDEETKDLIHRLFHPGEHVRDCLSDL 580 + +E +L+ + H+R + + Sbjct: 253 RTCPQEVYELMLGCWQREPHMRKNIKGI 280 >3ORP-A nrPDB Length = 311 Score = 89.0 bits (219), Expect = 8e-18, Method: Composition-based stats. Identities = 40/263 (15%), Positives = 84/263 (31%), Gaps = 60/263 (22%) Query: 365 IDEKYKIADTSEGGIYLGFYEKQE------VAVKTFCEGSPR-------AQREVSCLQSS 411 + ++Y++ + G + ++ VAVK R +RE ++ Sbjct: 10 LSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNA-AA 68 Query: 412 RENSHLVTFYGSESHRGHL----FVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSS 467 + +V Y + ++ + + D+ E + A V++ Sbjct: 69 LNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGV--TLRDIVHTE--GPMTPKRAIEVIAD 124 Query: 468 IFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI------------------- 508 +A+ H + G H+D++P NI+I + A + DF + Sbjct: 125 ACQALNFSHQN-GIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTA 183 Query: 509 ------KWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDL------KAQSNEEVVQLSP- 555 + GD + + D+ LG + LY V G F E+ + S Sbjct: 184 QYLSPEQARGDSVDARSDVYSLGCV-LYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSAR 242 Query: 556 ----DEETKDLIHRLFHPGEHVR 574 + ++ + R Sbjct: 243 HEGLSADLDAVVLKALAKNPENR 265 >3LZB-A nrPDB Length = 327 Score = 88.6 bits (218), Expect = 8e-18, Method: Composition-based stats. Identities = 45/272 (16%), Positives = 96/272 (35%), Gaps = 52/272 (19%) Query: 355 RPMIGKLKFFIDEKYKI-ADTSEGGIYLGFYEKQ------EVAVKTFCE-GSPRAQREV- 405 + ++ LK +K K+ + G +Y G + + VA+K E SP+A +E+ Sbjct: 6 QALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEIL 65 Query: 406 --SCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARN 463 + + +S +N H+ G + + L CL + E +N ++ N Sbjct: 66 DEAYVMASVDNPHVCRLLGICLT-STVQLITQLMPFG---CLLDYVREHKDNIGSQYLLN 121 Query: 464 VLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV------ 517 I K + L H+DL +N+L+ + + + DF + + +E Sbjct: 122 WCVQIAKGMNYL-EDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGK 180 Query: 518 ------------------KRDLEDLGRLVLYVVKKGSISFEDL----------KAQSNEE 549 + D+ G V ++ GS ++ + K + + Sbjct: 181 VPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQ 240 Query: 550 VVQLSPDEETKDLIHRLFHPGEHVRDCLSDLL 581 + D ++ + + R +L+ Sbjct: 241 PPICTID--VYMIMRKCWMIDADSRPKFRELI 270 >2HK5-A nrPDB Length = 270 Score = 88.6 bits (218), Expect = 8e-18, Method: Composition-based stats. Identities = 43/243 (17%), Positives = 91/243 (37%), Gaps = 40/243 (16%) Query: 370 KIADTSEGGIYLGFYEKQ-EVAVKTFCEGSPRAQR---EVSCLQSSRENSHLVTFYGSES 425 K+ G +++ Y K +VAVKT GS + E + ++ + ++ LV + + Sbjct: 22 KLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMK-TLQHDKLVKLHAVVT 80 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 +++ + + LD + ++ + + + I + + + Y H+D Sbjct: 81 KEP-IYIITEFMAKG--SLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFI-EQRNYIHRD 136 Query: 486 LQPQNILIDSKKAAHLADFDKS-----------------IKWAG------DPQEVKRDLE 522 L+ NIL+ + +ADF + IKW +K D+ Sbjct: 137 LRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVW 196 Query: 523 DLGRLVLYVVKKGSISF------EDLKAQSNEEVVQLSPD--EETKDLIHRLFHPGEHVR 574 G L++ +V G I + E ++A + + EE +++ R + R Sbjct: 197 SFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEER 256 Query: 575 DCL 577 Sbjct: 257 PTF 259 >5X02-A nrPDB Length = 347 Score = 88.6 bits (218), Expect = 8e-18, Method: Composition-based stats. Identities = 38/286 (13%), Positives = 79/286 (27%), Gaps = 69/286 (24%) Query: 363 FFIDEKYKIADTSEGGIYLGFYEKQ-----------EVAVKTFCEGSPRAQRE-----VS 406 F E + G + +VAVK E + ++RE + Sbjct: 44 EFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELK 103 Query: 407 CLQSSRENSHLVTFYGSESHRGHLFVCVTLC------------EQTLEACLDVHRGEDVE 454 + + ++V G+ + G +++ C + + + Sbjct: 104 MMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRL 163 Query: 455 NEEDEFARNVL-------SSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 EE++ + K ++ L H+DL +N+L+ K + DF + Sbjct: 164 EEEEDLNVLTFEDLLCFAYQVAKGMEFLEFK-SCVHRDLAARNVLVTHGKVVKICDFGLA 222 Query: 508 IKWAGDPQEV------------------------KRDLEDLGRLVLYVVKKGSISFEDLK 543 D V K D+ G L+ + G + + Sbjct: 223 RDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIP 282 Query: 544 AQSNEEVV---------QLSPDEETKDLIHRLFHPGEHVRDCLSDL 580 +N + EE ++ + R +L Sbjct: 283 VDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 328 >4XUF-A nrPDB Length = 297 Score = 88.6 bits (218), Expect = 8e-18, Method: Composition-based stats. Identities = 38/286 (13%), Positives = 79/286 (27%), Gaps = 69/286 (24%) Query: 363 FFIDEKYKIADTSEGGIYLGFYEKQ-----------EVAVKTFCEGSPRAQRE-----VS 406 F E + G + +VAVK E + ++RE + Sbjct: 5 EFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELK 64 Query: 407 CLQSSRENSHLVTFYGSESHRGHLFVCVTLC------------EQTLEACLDVHRGEDVE 454 + + ++V G+ + G +++ C + + + Sbjct: 65 MMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRL 124 Query: 455 NEEDEFARNVL-------SSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 EE++ + K ++ L H+DL +N+L+ K + DF + Sbjct: 125 EEEEDLNVLTFEDLLCFAYQVAKGMEFLEFK-SCVHRDLAARNVLVTHGKVVKICDFGLA 183 Query: 508 IKWAGDPQEV------------------------KRDLEDLGRLVLYVVKKGSISFEDLK 543 D V K D+ G L+ + G + + Sbjct: 184 RDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIP 243 Query: 544 AQSNEEVV---------QLSPDEETKDLIHRLFHPGEHVRDCLSDL 580 +N + EE ++ + R +L Sbjct: 244 VDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 289 >4IAN-A nrPDB Length = 358 Score = 88.6 bits (218), Expect = 9e-18, Method: Composition-based stats. Identities = 50/222 (22%), Positives = 82/222 (36%), Gaps = 43/222 (19%) Query: 354 YRPMIGKLKFFIDEKYKIADTSEGGIYLGFYE-------KQEVAVKTFCEG---SPRAQR 403 YR IG++ +D++Y + + G++ QEVAVK + Sbjct: 20 YRVNIGEV---LDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLK 76 Query: 404 EVSCLQSSRENS-----HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEED 458 E+ L+ + H + + H+ HL + L L + G+DV Sbjct: 77 ELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKY-GKDVGLHIK 135 Query: 459 EFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAA-HLADFDKSIKWAGD---P 514 R+ +F A++ L C H D++P NIL++ K L DF + A + P Sbjct: 136 AV-RSYSQQLFLALKLLKR-CNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITP 193 Query: 515 QEVKR-----------------DLEDLGRLVLYVVKKGSISF 539 V R D+ +G LY + G I F Sbjct: 194 YLVSRFYRAPEIIIGKSYDYGIDMWSVGCT-LYELYTGKILF 234 Score = 33.1 bits (74), Expect = 0.48, Method: Composition-based stats. Identities = 7/29 (24%), Positives = 13/29 (44%) Query: 558 ETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + KDL+ ++ R ++ L H F Sbjct: 320 QLKDLLDQILMLDPAKRISINQALQHAFI 348 >4YHJ-A nrPDB Length = 584 Score = 88.6 bits (218), Expect = 9e-18, Method: Composition-based stats. Identities = 34/223 (15%), Positives = 73/223 (32%), Gaps = 42/223 (18%) Query: 401 AQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEF 460 A E L+ ++ +V+ + + L + +T+ + G +++ Sbjct: 232 ALNEKRILEKV-QSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGN--PGFDEQR 288 Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK----------- 509 A + + +++L ++DL+P+NIL+D + ++D + + Sbjct: 289 AVFYAAELCCGLEDL-QRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRV 347 Query: 510 ----------WAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSP---- 555 + D LG L+ Y + +G F+ K + E V Sbjct: 348 GTVGYMAPEVVNNEKYTFSPDWWGLGCLI-YEMIQGHSPFKKYKEKVKWEEVDQRIKNDT 406 Query: 556 -------DEETKDLIHRLFHPGEHVRD-----CLSDLLGHPFF 586 E+ K + L R + + HP F Sbjct: 407 EEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVF 449 >5VC6-A nrPDB Length = 289 Score = 88.2 bits (217), Expect = 1e-17, Method: Composition-based stats. Identities = 42/276 (15%), Positives = 89/276 (32%), Gaps = 57/276 (20%) Query: 370 KIADTSEGGIYL--GFYEKQEVAVKTFCE------GSPRAQREVSCLQSSRENSHLVTFY 421 KI G ++ + A+K + A REV ++SH+V ++ Sbjct: 18 KIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYF 77 Query: 422 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 + + H+ + C A + ++ +++L + + ++ +H S Sbjct: 78 SAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIH-SMSL 136 Query: 482 THQDLQPQNILIDS-------------------KKAAHLADFDKSIKWA------GDPQE 516 H D++P NI I K + D + + GD + Sbjct: 137 VHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRF 196 Query: 517 V-------------KRDLEDLGRLVLYVVKKGSIS-------FEDLKAQSNEEVVQLSPD 556 + K D+ L V V G+ + +++ + Q+ Sbjct: 197 LANEVLQENYTHLPKADIFALALTV--VCAAGAEPLPRNGDQWHEIRQGRLPRIPQV-LS 253 Query: 557 EETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESR 592 +E +L+ + HP R L+ H + + Sbjct: 254 QEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRK 289 >4Y93-A nrPDB Length = 446 Score = 87.8 bits (216), Expect = 1e-17, Method: Composition-based stats. Identities = 44/249 (17%), Positives = 86/249 (34%), Gaps = 40/249 (16%) Query: 370 KIADTSEGGIYLGFYEKQ-EVAVKTFCEGS---PRAQREVSCLQSSRENSHLVTFYGSES 425 ++ G + G + Q +VA+K EGS E + + + LV YG + Sbjct: 195 ELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLS-HEKLVQLYGVCT 253 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 + +F+ CL + E + + + + +A++ L S + H+D Sbjct: 254 KQRPIFIITEYMANG---CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL-ESKQFLHRD 309 Query: 486 LQPQNILIDSKKAAHLADFDKSI-----------------KWAG------DPQEVKRDLE 522 L +N L++ + ++DF + KWA K D+ Sbjct: 310 LAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSKFSSKSDIW 369 Query: 523 DLGRLVLYVVKKGSISFEDLKAQSNEEVV----QLS----PDEETKDLIHRLFHPGEHVR 574 G L+ + G + +E E + +L E +++ +H R Sbjct: 370 AFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYAIMYSCWHEKADER 429 Query: 575 DCLSDLLGH 583 LL + Sbjct: 430 PTFKILLSN 438 >4BTK-A nrPDB Length = 337 Score = 87.8 bits (216), Expect = 1e-17, Method: Composition-based stats. Identities = 42/245 (17%), Positives = 92/245 (37%), Gaps = 47/245 (19%) Query: 362 KFFIDEKYKIADTSEGGIYLGFYEK------QEVAVKTFCEGSPRA--QREVSCLQSSRE 413 + + +++K+ GG + YE + VA+K P+ + EV+ L+ + Sbjct: 51 NYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQG 110 Query: 414 NSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQ 473 H+ F G + +V + L + L D+ R + + I ++++ Sbjct: 111 KDHVCRFIGCGRNEKFNYVVMQLQGRNLA---DLRRSQPRGTFTLSTTLRLGKQILESIE 167 Query: 474 ELHLSCGYTHQDLQPQNI----LIDSKKAAHLADFDKSIKWAGDPQEVK----------- 518 +H S G+ H+D++P N L + + ++ DF + ++ +V+ Sbjct: 168 AIH-SVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGT 226 Query: 519 -----------------RDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKD 561 DL L +L G + + +K + E+V + E + Sbjct: 227 VRYASVNAHKNREMGRHDDLWSL-FYMLVEFAVGQLPWRKIKDK--EQVGMIKEKYEHRM 283 Query: 562 LIHRL 566 L+ + Sbjct: 284 LLKHM 288 >4M7I-A nrPDB Length = 299 Score = 87.8 bits (216), Expect = 1e-17, Method: Composition-based stats. Identities = 43/274 (15%), Positives = 83/274 (30%), Gaps = 61/274 (22%) Query: 371 IADTSEGGIY--LGFYEKQEVAVKTFCE-----GSPRAQREVSCLQSSRENSHLVTFYGS 423 + G ++ + A+K + REV L E+ +V ++ + Sbjct: 13 LGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKL-EHPGIVRYFNA 71 Query: 424 ESHRG------------HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 471 + +L++ + LC + R +E E ++ I +A Sbjct: 72 WLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRC-TIEERERSVCLHIFLQIAEA 130 Query: 472 VQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI----------------------- 508 V+ LH S G H+DL+P NI + DF Sbjct: 131 VEFLH-SKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTG 189 Query: 509 -----------KWAGDPQEVKRDLEDLGRL---VLYVVKKGSISFEDLKAQSNEEVVQLS 554 + G+ K D+ LG + +LY L N + L Sbjct: 190 QVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLF 249 Query: 555 PDEETKD--LIHRLFHPGEHVRDCLSDLLGHPFF 586 + + ++ + P R +++ + F Sbjct: 250 TQKYPCEYVMVQDMLSPSPMERPEAINIIENAVF 283 >6O6Q-A nrPDB Length = 335 Score = 87.8 bits (216), Expect = 2e-17, Method: Composition-based stats. Identities = 48/301 (15%), Positives = 92/301 (30%), Gaps = 83/301 (27%) Query: 361 LKFFIDEKYKIADTSEGGIYLGFY------EKQEVAVKTF-CEGSPRAQREVSCLQSSRE 413 +K+ E Y+I G Y + ++++V +K + +RE+S L++ + Sbjct: 35 IKWNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKKIKREISILKNLVD 94 Query: 414 NSHLVTFYGS--ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 471 +++ E + + D R + + KA Sbjct: 95 GPNIIAMLDVVREPQSKTPGLIFEHINN-------IDFRSLYPTFTDYDIRFYMYELLKA 147 Query: 472 VQELHLSCGYTHQDLQPQNILID-SKKAAHLADFDKSIKW-AGDPQEVKR---------- 519 + H S G H+D++P N++ID KK L D+ + + G V+ Sbjct: 148 LDYSH-SMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPEL 206 Query: 520 -----------DLEDLGRLVLYVVKKGSISF----------------------------- 539 D+ G ++ +V F Sbjct: 207 LVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYN 266 Query: 540 -------EDLKAQSNEEVVQLSP-------DEETKDLIHRLFHPGEHVRDCLSDLLGHPF 585 ED+ + + V+ +E DLI RL R + + H + Sbjct: 267 ISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHAY 326 Query: 586 F 586 F Sbjct: 327 F 327 >6DVZ-A nrPDB Length = 791 Score = 87.8 bits (216), Expect = 2e-17, Method: Composition-based stats. Identities = 51/282 (18%), Positives = 104/282 (36%), Gaps = 44/282 (15%) Query: 7 NNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNA 66 N+P R+ + AV V+ +++LL+ ++ + G Sbjct: 101 NSPSANLAKEEQRQKKKRLKKRIFAAVSEGCVEELRELLQDLQDL-CRRRRG-------- 151 Query: 67 VQMSREDIVELLLRHGADPVLRKKNGATPFILA---AIAGSVKLLKLFLSKGADVNECD- 122 D+ + L+ + G T + A + +++++ L+ + + D Sbjct: 152 -----LDVPDFLMHK----LTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILDR 202 Query: 123 ----------FYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRK----TKEDQERLRKGG 168 + G TA A + L GA+VN K + Q G Sbjct: 203 FINAEYTEEAYEGQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFG 262 Query: 169 ATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSD-----VEAITH 223 T L AA E++++L++ D+ + D+ G N L + ++D V+ + Sbjct: 263 ETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYD 322 Query: 224 LLLDHGADV---NVRGERGKTPLILAVEKKHLGLVQRLLEQE 262 ++L + +R G TPL LA + +++ +L +E Sbjct: 323 MILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSRE 364 Score = 62.0 bits (149), Expect = 8e-10, Method: Composition-based stats. Identities = 50/239 (20%), Positives = 87/239 (36%), Gaps = 43/239 (17%) Query: 99 AAIAGSVKLLKLFLS---------KGADV-----NECDFY--GFTAFMEAAVY---GKVK 139 A G V+ L+ L +G DV ++ G T M+A + + Sbjct: 126 AVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTASDTGKTCLMKALLNINPNTKE 185 Query: 140 ALKFLYKRGANVNLRRKTKED-QERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNAC 198 ++ L ++ + G TAL A E+ ++ +L+ GADVNA Sbjct: 186 IVRILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIERRQGDITAVLIAA-GADVNAH 244 Query: 199 ----------DNMGRNALIHALLSSDDSDVEAITHLLLDH-GADVNVRGERGKTPLILAV 247 + G L + ++ I LL+++ D+ + RG L V Sbjct: 245 AKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALV 304 Query: 248 E-----KKHLGLVQR-----LLEQEHIEI-NDTDSDGKTALLLAVELKLKKIAELLCKR 295 K V+R LL + E+ ++DG T L LA ++ +I + + R Sbjct: 305 TVAEDFKTQNDFVKRMYDMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSR 363 Score = 42.4 bits (98), Expect = 8e-04, Method: Composition-based stats. Identities = 29/128 (22%), Positives = 58/128 (45%), Gaps = 11/128 (8%) Query: 175 AAEKGHVEVLKILLDEMGADVNACDNMG-RNALIHALLSSDDSDVEAITHLLLDHGADVN 233 A +G VE L+ LL ++ + + L+H L +SD + LL ++N Sbjct: 126 AVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTASDTGKTCLMKALL-----NIN 180 Query: 234 VRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLC 293 + ++LA +++ ++ R + + E + +G+TAL +A+E + I +L Sbjct: 181 -PNTKEIVRILLAFAEEN-DILDRFI---NAEYTEEAYEGQTALNIAIERRQGDITAVLI 235 Query: 294 KRGASTDC 301 GA + Sbjct: 236 AAGADVNA 243 >6DC0-A nrPDB Length = 292 Score = 87.4 bits (215), Expect = 2e-17, Method: Composition-based stats. Identities = 38/239 (15%), Positives = 69/239 (28%), Gaps = 42/239 (17%) Query: 383 FYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLE 442 + +E+ K F Q ++ +S++ +V + Sbjct: 28 IHTGRELRCKVFP--IKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFE---KDFG 82 Query: 443 ACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHL- 501 R EE+ A + I AV H S DL+ + + +++ L Sbjct: 83 DMHSYVRSRKRLREEE--AARLFKQIVSAVAHCHQSA-IVLGDLKLRKFVFSTEERTQLR 139 Query: 502 ------------ADFDKSIK-------------WAGDPQEVKRDLEDLGRLVLYVVKKGS 536 D S K G D+ LG ++LY + G Sbjct: 140 LESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLG-VMLYTLLVGR 198 Query: 537 ISFEDLKAQSNEEVVQL-------SPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWT 588 F D + ++ + + LI L R ++L HP+F + Sbjct: 199 YPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFES 257 >5CEK-A nrPDB Length = 263 Score = 87.4 bits (215), Expect = 2e-17, Method: Composition-based stats. Identities = 38/239 (15%), Positives = 69/239 (28%), Gaps = 42/239 (17%) Query: 383 FYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLE 442 + +E+ K F Q ++ +S++ +V + Sbjct: 31 IHTGRELRCKVFP--IKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFE---KDFG 85 Query: 443 ACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHL- 501 R EE+ A + I AV H S DL+ + + +++ L Sbjct: 86 DMHSYVRSRKRLREEE--AARLFKQIVSAVAHCHQSA-IVLGDLKLRKFVFSTEERTQLR 142 Query: 502 ------------ADFDKSIK-------------WAGDPQEVKRDLEDLGRLVLYVVKKGS 536 D S K G D+ LG ++LY + G Sbjct: 143 LESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLG-VMLYTLLVGR 201 Query: 537 ISFEDLKAQSNEEVVQL-------SPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWT 588 F D + ++ + + LI L R ++L HP+F + Sbjct: 202 YPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFES 260 >3BBT-B nrPDB Length = 328 Score = 87.4 bits (215), Expect = 2e-17, Method: Composition-based stats. Identities = 48/288 (16%), Positives = 89/288 (30%), Gaps = 56/288 (19%) Query: 370 KIADTSEGGIYLGFYEKQ------EVAVKTFCEGS-PRAQREV---SCLQSSRENSHLVT 419 + + G +Y G + + VA+K E + P+A E + + +S ++ HLV Sbjct: 22 VLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVR 81 Query: 420 FYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSC 479 G + + L CL + E +N + N I K + L Sbjct: 82 LLGVCLS-PTIQLVTQLMP---HGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYL-EER 136 Query: 480 GYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV---------------------- 517 H+DL +N+L+ S + DF + GD +E Sbjct: 137 RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF 196 Query: 518 --KRDLEDLGRLVLYVVKKGSISFEDL----------KAQSNEEVVQLSPDEETKDLIHR 565 + D+ G + ++ G ++ + K + + + D + Sbjct: 197 THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW 256 Query: 566 LFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESE 613 + R + L F R L G+ K S Sbjct: 257 MIDADS--RPKFKE-LAAEFSRMARDPQRYLVIQGD----DRMKLPSP 297 >4NFN-A nrPDB Length = 309 Score = 87.1 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 42/245 (17%), Positives = 92/245 (37%), Gaps = 47/245 (19%) Query: 362 KFFIDEKYKIADTSEGGIYLGFYEK------QEVAVKTFCEGSPRA--QREVSCLQSSRE 413 + + +++K+ GG + YE + VA+K P+ + EV+ L+ + Sbjct: 16 NYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQG 75 Query: 414 NSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQ 473 H+ F G + +V + L + L D+ R + + I ++++ Sbjct: 76 KDHVCRFIGCGRNEKFNYVVMQLQGRNLA---DLRRSQPRGTFTLSTTLRLGKQILESIE 132 Query: 474 ELHLSCGYTHQDLQPQNI----LIDSKKAAHLADFDKSIKWAGDPQEVK----------- 518 +H S G+ H+D++P N L + + ++ DF + ++ +V+ Sbjct: 133 AIH-SVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGT 191 Query: 519 -----------------RDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKD 561 DL L +L G + + +K + E+V + E + Sbjct: 192 VRYASVNAHKNREMGRHDDLWSL-FYMLVEFAVGQLPWRKIKDK--EQVGMIKEKYEHRM 248 Query: 562 LIHRL 566 L+ + Sbjct: 249 LLKHM 253 >2VWV-A nrPDB Length = 302 Score = 87.1 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 45/265 (16%), Positives = 87/265 (32%), Gaps = 49/265 (18%) Query: 361 LKFFIDEKYKIADTSEGGIYLGFYEKQE-----VAVKTFCEGSP-RAQREV---SCLQSS 411 + + E+ I G + G + VA+KT G R +RE + + Sbjct: 15 VSYVKIEE-VIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQ 73 Query: 412 RENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 471 E+ +++ G ++ + + E LD + +L I Sbjct: 74 FEHPNIIRLEGVVTNSMPVMILTEFMENGA---LDSFLRLNDGQFTVIQLVGMLRGIASG 130 Query: 472 VQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI---KWAGDPQEVK---------- 518 ++ L Y H+DL +NIL++S ++DF S + + DP E Sbjct: 131 MRYL-AEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRW 189 Query: 519 --------------RDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQ----LSPDEETK 560 D G ++ V+ G + D+ Q ++ L P + Sbjct: 190 TAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCP 249 Query: 561 DLIHRLF----HPGEHVRDCLSDLL 581 +H+L + R ++ Sbjct: 250 TSLHQLMLDCWQKDRNARPRFPQVV 274 >2Y6O-A nrPDB Length = 291 Score = 86.7 bits (213), Expect = 3e-17, Method: Composition-based stats. Identities = 48/262 (18%), Positives = 87/262 (33%), Gaps = 48/262 (18%) Query: 364 FIDEKYKIADTSEGGIYLGFYE---KQE--VAVKTFCEGSPRAQR-----EVSCLQSSRE 413 I + I G + G + K+E VA+KT G QR E S + + Sbjct: 15 CIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQF-D 73 Query: 414 NSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQ 473 + +++ G + + + E LD ++ +L I ++ Sbjct: 74 HPNIIHLEGVVTKCKPVMIITEYMENGS---LDAFLRKNDGRFTVIQLVGMLRGIGSGMK 130 Query: 474 ELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQ------------------ 515 L Y H+DL +NIL++S ++DF S DP+ Sbjct: 131 YL-SDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPE 189 Query: 516 -------EVKRDLEDLGRLVLYVVKKGSISFEDLKAQ----SNEEVVQLSPDEETKDLIH 564 D+ G ++ V+ G + D+ Q + EE +L P + +H Sbjct: 190 AIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALH 249 Query: 565 RLF----HPGEHVRDCLSDLLG 582 +L R ++ Sbjct: 250 QLMLDCWQKERSDRPKFGQIVN 271 >6GQK-A nrPDB Length = 328 Score = 86.7 bits (213), Expect = 4e-17, Method: Composition-based stats. Identities = 40/245 (16%), Positives = 71/245 (28%), Gaps = 51/245 (20%) Query: 389 VAVKTFCEGSPRAQRE-----VSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQT-LE 442 VAVK + +RE + L + ++V G+ +H G V C L Sbjct: 74 VAVKMLKPSAHSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLL 133 Query: 443 ACLDVHRGEDVENE--EDEFARNVL---------SSIFKAVQELHLSCGYTHQDLQPQNI 491 L R E V + ++ ++ L + K + L S H+DL +NI Sbjct: 134 NFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFL-ASKNCIHRDLAARNI 192 Query: 492 LIDSKKAAHLADFDKSIKWAGDPQEV------------------------KRDLEDLGRL 527 L+ + DF + D V + D+ G Sbjct: 193 LLTHGNITKICDFGLARDIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIF 252 Query: 528 VLYVVKKGSIS---------FEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLS 578 + + GS F + + E D++ + R Sbjct: 253 LWELFSLGSSPYPGMPVDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFK 312 Query: 579 DLLGH 583 ++ Sbjct: 313 QIVQD 317 >5GRN-A nrPDB Length = 356 Score = 86.3 bits (212), Expect = 4e-17, Method: Composition-based stats. Identities = 40/272 (14%), Positives = 79/272 (29%), Gaps = 65/272 (23%) Query: 372 ADTSEGGIYLGFYEKQEV---AVKTFCEGSPRAQR-----EVSCLQSSRENSHLVTFYGS 423 EG Y G Q V AVK + +++ E+ + + ++V G+ Sbjct: 60 GKVVEGTAY-GLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGA 118 Query: 424 ESHRGHLFVCVTLCEQT-----LEACLDVHRGEDVENEEDEFARNVL------------- 465 + G +++ C L D ++ D +N+L Sbjct: 119 CTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDL 178 Query: 466 ----SSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVK--- 518 + + ++ L S H+DL +N+L+ K + DF + D V Sbjct: 179 LSFTYQVARGMEFL-ASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGS 237 Query: 519 ---------------------RDLEDLGRLVLYVVKKGSISF------EDLKAQSNEEVV 551 D+ G L+ + G + + Sbjct: 238 TFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYR 297 Query: 552 QLSPD---EETKDLIHRLFHPGEHVRDCLSDL 580 PD E +++ + ++ R L Sbjct: 298 MAKPDHATSEVYEIMVKCWNSEPEKRPSFYHL 329 >3TT0-A nrPDB Length = 382 Score = 85.9 bits (211), Expect = 5e-17, Method: Composition-based stats. Identities = 44/316 (13%), Positives = 90/316 (28%), Gaps = 71/316 (22%) Query: 331 PPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQ--- 387 P E+ Q G + +L R ++ + G + + Sbjct: 39 PTTENLYFQGMLAGVSEYELPEDPR------WELPRDRLVLGKPLGEGAFGQVVLAEAIG 92 Query: 388 ----------EVAVKTFCEGSPRAQ-----REVSCLQSSRENSHLVTFYGSESHRGHLFV 432 +VAVK + E+ ++ ++ +++ G+ + G L+V Sbjct: 93 LDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYV 152 Query: 433 CVTLCEQT-LEACLDVHRG-------EDVENEEDEFAR----NVLSSIFKAVQELHLSCG 480 V + L L R N E++ + + + + ++ L S Sbjct: 153 IVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYL-ASKK 211 Query: 481 YTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVK---------------------- 518 H+DL +N+L+ +ADF + K Sbjct: 212 CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYT 271 Query: 519 --RDLEDLGRLVLYVVKKGSIS---------FEDLKAQSNEEVVQLSPDEETKDLIHRLF 567 D+ G L+ + G F+ LK + + E ++ + Sbjct: 272 HQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS-NCTNELYMMMRDCW 330 Query: 568 HPGEHVRDCLSDLLGH 583 H R L+ Sbjct: 331 HAVPSQRPTFKQLVED 346 >3QUP-A nrPDB Length = 323 Score = 85.9 bits (211), Expect = 6e-17, Method: Composition-based stats. Identities = 41/271 (15%), Positives = 86/271 (31%), Gaps = 57/271 (21%) Query: 363 FFIDEKYKIADTSEGGIYLGFYEKQ---------EVAVKTF------CEGSPRAQREVSC 407 ++++ + G + E Q +VAVK RE +C Sbjct: 19 LIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAAC 78 Query: 408 LQSSRENSHLVTFYGS-ESHRGHLFVCVTLCEQTLEACLDVH-------RGEDVENEEDE 459 ++ ++ H+ G R + + + D+H GE+ N + Sbjct: 79 MKEF-DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQ 137 Query: 460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK---------- 509 + I ++ L S + H+DL +N ++ +ADF S K Sbjct: 138 TLVRFMVDIACGMEYL-SSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQG 196 Query: 510 --------------WAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQ------SNEE 549 A + V D+ G + ++ +G + ++ Sbjct: 197 CASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGN 256 Query: 550 VVQLSPD--EETKDLIHRLFHPGEHVRDCLS 578 ++ P+ EE DL+++ + R + Sbjct: 257 RLKQPPECMEEVYDLMYQCWSADPKQRPSFT 287 >3V5Q-A nrPDB Length = 297 Score = 85.9 bits (211), Expect = 6e-17, Method: Composition-based stats. Identities = 43/271 (15%), Positives = 86/271 (31%), Gaps = 59/271 (21%) Query: 368 KYKIADTSEGGIYLG-------FYEKQEVAVKTFCEGS----PRAQREVSCLQSSRENSH 416 K ++ + + G ++L +K VAVK + + QRE L + ++ H Sbjct: 20 KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNL-QHEH 78 Query: 417 LVTFYGSESHRGHLFVCVTLC-EQTLEACLDVHRGEDV--ENEEDEFAR---------NV 464 +V FYG L + L L H + + + + A+ ++ Sbjct: 79 IVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHI 138 Query: 465 LSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE-------- 516 S I + L S + H+DL +N L+ + + DF S Sbjct: 139 ASQIASGMVYL-ASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTML 197 Query: 517 ----------------VKRDLEDLGRLVLYVVKKGSISFEDL---------KAQSNEEVV 551 + D+ G ++ + G + L E Sbjct: 198 PIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERP 257 Query: 552 QLSPDEETKDLIHRLFHPGEHVRDCLSDLLG 582 ++ P +E D++ + R + ++ Sbjct: 258 RVCP-KEVYDVMLGCWQREPQQRLNIKEIYK 287 >4N5Q-A nrPDB Length = 257 Score = 85.5 bits (210), Expect = 7e-17, Method: Composition-based stats. Identities = 48/257 (18%), Positives = 98/257 (38%), Gaps = 44/257 (17%) Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91 AV V+ +++LL+ ++ + G D+ + L+ + Sbjct: 10 AVSEGCVEELRELLQDLQDL-CRRRRG-------------LDVPDFLMHK----LTASDT 51 Query: 92 GATPFILA---AIAGSVKLLKLFLSKGADVNECD-----------FYGFTAFMEAAVYGK 137 G T + A + +++++ L+ + + D + G TA A + Sbjct: 52 GKTCLMKALLNINPNTKEIVRILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIERRQ 111 Query: 138 VKALKFLYKRGANVNLRRK----TKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGA 193 L GA+VN K + Q G T L AA E++++L++ Sbjct: 112 GDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQT 171 Query: 194 DVNACDNMGRNALIHALLSSDDSD-----VEAITHLLLDHGADV---NVRGERGKTPLIL 245 D+ + D+ G N L + ++D V+ + ++L + +R G TPL L Sbjct: 172 DITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETMRNNDGLTPLQL 231 Query: 246 AVEKKHLGLVQRLLEQE 262 A + +++ +L +E Sbjct: 232 AAKMGKAEILKYILSRE 248 Score = 60.9 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 50/239 (20%), Positives = 87/239 (36%), Gaps = 43/239 (17%) Query: 99 AAIAGSVKLLKLFLS---------KGADV-----NECDFY--GFTAFMEAAVY---GKVK 139 A G V+ L+ L +G DV ++ G T M+A + + Sbjct: 10 AVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTASDTGKTCLMKALLNINPNTKE 69 Query: 140 ALKFLYKRGANVNLRRKTKED-QERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNAC 198 ++ L ++ + G TAL A E+ ++ +L+ GADVNA Sbjct: 70 IVRILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIERRQGDITAVLIAA-GADVNAH 128 Query: 199 ----------DNMGRNALIHALLSSDDSDVEAITHLLLDH-GADVNVRGERGKTPLILAV 247 + G L + ++ I LL+++ D+ + RG L V Sbjct: 129 AKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALV 188 Query: 248 E-----KKHLGLVQR-----LLEQEHIEI-NDTDSDGKTALLLAVELKLKKIAELLCKR 295 K V+R LL + E+ ++DG T L LA ++ +I + + R Sbjct: 189 TVAEDFKTQNDFVKRMYDMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSR 247 Score = 56.6 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 35/152 (23%), Positives = 53/152 (34%), Gaps = 26/152 (17%) Query: 22 AVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQ----------EEEG---GWTPLHNAVQ 68 A E L A++ D+ L+ GA+VN + EG G TPL A Sbjct: 96 AYEGQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAAC 155 Query: 69 MSREDIVELLLRH-GADPVLRKKNGATPFILAAIAGSV-----KLLKL-----FLSKG-- 115 ++ +IV+LL+ + D + G +K L G Sbjct: 156 TNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNW 215 Query: 116 ADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147 + G T AA GK + LK++ R Sbjct: 216 ELETMRNNDGLTPLQLAAKMGKAEILKYILSR 247 Score = 42.0 bits (97), Expect = 0.001, Method: Composition-based stats. Identities = 29/128 (22%), Positives = 58/128 (45%), Gaps = 11/128 (8%) Query: 175 AAEKGHVEVLKILLDEMGADVNACDNMG-RNALIHALLSSDDSDVEAITHLLLDHGADVN 233 A +G VE L+ LL ++ + + L+H L +SD + LL ++N Sbjct: 10 AVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTASDTGKTCLMKALL-----NIN 64 Query: 234 VRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLC 293 + ++LA +++ ++ R + + E + +G+TAL +A+E + I +L Sbjct: 65 -PNTKEIVRILLAFAEEN-DILDRFI---NAEYTEEAYEGQTALNIAIERRQGDITAVLI 119 Query: 294 KRGASTDC 301 GA + Sbjct: 120 AAGADVNA 127 >1G3N-B nrPDB Length = 168 Score = 85.5 bits (210), Expect = 8e-17, Method: Composition-based stats. Identities = 47/199 (23%), Positives = 74/199 (37%), Gaps = 49/199 (24%) Query: 99 AAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTK 158 AA G ++ L L +VN + +G TA G + + L RGAN +L+ +T Sbjct: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKDRT- 69 Query: 159 EDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDV 218 G + DAA G ++ L+ L Sbjct: 70 ---------GFAVIHDAARAGFLDTLQTL------------------------------- 89 Query: 219 EAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALL 278 L+ ADVN+ G PL LA ++ HL +V+ L++ + + G TA Sbjct: 90 -------LEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACD 142 Query: 279 LAVELKLKKIAELLCKRGA 297 LA ++ L+ GA Sbjct: 143 LARLYGRNEVVSLMQANGA 161 Score = 84.8 bits (208), Expect = 1e-16, Method: Composition-based stats. Identities = 50/165 (30%), Positives = 70/165 (42%), Gaps = 12/165 (7%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 L A D++ + LL+ NVN Q G T L +++ +I LL GA+P L+ Sbjct: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFG-RTALQV-MKLGNPEIARRLLLRGANPDLK 66 Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG 148 + G AA AG + L+ L ADVN D G AA G ++ ++FL K Sbjct: 67 DRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHT 126 Query: 149 ANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGA 193 A+ R G TA A G EV+ L+ GA Sbjct: 127 ASNVGHR---------NHKGDTACDLARLYGRNEVVS-LMQANGA 161 Score = 74.4 bits (181), Expect = 2e-13, Method: Composition-based stats. Identities = 42/161 (26%), Positives = 66/161 (40%), Gaps = 13/161 (8%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 L AA +G +E L LL A + GR AL L + I LL GA+ Sbjct: 9 LASAAARGDLEQLTSLLQNNVNVN-AQNGFGRTALQVMKLGN-----PEIARRLLLRGAN 62 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAEL 291 +++ G + A L +Q LLE ++N D++G L LA + ++ E Sbjct: 63 PDLKDRTGFAVIHDAARAGFLDTLQTLLE-FQADVNIEDNEGNLPLHLAAKEGHLRVVEF 121 Query: 292 LCKRGAS-TDCGDLVM-----TARRNYDHSLVKVLLSHGAK 326 L K AS + AR + +V ++ ++GA Sbjct: 122 LVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAG 162 Score = 37.4 bits (85), Expect = 0.025, Method: Composition-based stats. Identities = 15/62 (24%), Positives = 26/62 (41%) Query: 22 AVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRH 81 E N L A + + +V+ L++ A+ G T A R ++V L+ + Sbjct: 100 DNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQAN 159 Query: 82 GA 83 GA Sbjct: 160 GA 161 >5KMM-A nrPDB Length = 329 Score = 85.1 bits (209), Expect = 9e-17, Method: Composition-based stats. Identities = 47/268 (17%), Positives = 81/268 (30%), Gaps = 58/268 (21%) Query: 368 KYKIADTSEGGIYLGF-------YEKQEVAVKTFCEGSPRA----QREVSCLQSSRENSH 416 K+++ + + G ++L +K VAVK E S A QRE L ++ H Sbjct: 40 KWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLT-MLQHQH 98 Query: 417 LVTFYGSESHRGHLFVCVTLC-EQTLEACLDVHR--------GEDVENEEDEFAR--NVL 465 +V F+G + L + L L H GEDV + V Sbjct: 99 IVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVA 158 Query: 466 SSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE--------- 516 S + + L + H+DL +N L+ + DF S Sbjct: 159 SQVAAGMVYL-AGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLP 217 Query: 517 ---------------VKRDLEDLGRLVLYVVKKGSISFEDL---------KAQSNEEVVQ 552 + D+ G ++ + G + L E + Sbjct: 218 IRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPR 277 Query: 553 LSPDEETKDLIHRLFHPGEHVRDCLSDL 580 P E ++ + R + D+ Sbjct: 278 ACP-PEVYAIMRGCWQREPQQRHSIKDV 304 >4XCU-A nrPDB Length = 300 Score = 85.1 bits (209), Expect = 1e-16, Method: Composition-based stats. Identities = 41/279 (14%), Positives = 77/279 (27%), Gaps = 56/279 (20%) Query: 358 IGKLKFFIDEKYKIADTSEGGIYLGFYEKQ-------------EVAVKTFCEGSPRAQ-- 402 + L F ++ + G + + VAVK + + Sbjct: 8 LDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLA 67 Query: 403 ---REVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQT-LEACLDVHR--GEDVENE 456 E+ ++ + +++ G + G L+V V + L L R G Sbjct: 68 DLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPL 127 Query: 457 EDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE 516 + + + +Q L S H+DL +N+L+ +ADF + Sbjct: 128 SFPVLVSCAYQVARGMQYL-ESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYY 186 Query: 517 VK------------------------RDLEDLGRLVLYVVKKGSIS---------FEDLK 543 K D+ G L+ + G F L+ Sbjct: 187 KKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLR 246 Query: 544 AQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLG 582 + P E L+ +H R L+ Sbjct: 247 EGHRMDRPPHCP-PELYGLMRECWHAAPSQRPTFKQLVE 284 >5EG3-A nrPDB Length = 334 Score = 85.1 bits (209), Expect = 1e-16, Method: Composition-based stats. Identities = 40/284 (14%), Positives = 84/284 (29%), Gaps = 65/284 (22%) Query: 363 FFIDEKYKIADTSEGGIYLGFYEKQ-------------EVAVKTFCEGSPRAQ-----RE 404 F +K + G + + VAVK + + E Sbjct: 31 EFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 90 Query: 405 VSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQT-LEACLDVHRGE--------DVEN 455 + ++ ++ +++ G+ + G L+V V + L L R + Sbjct: 91 MEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVP 150 Query: 456 EEDEFAR---NVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAG 512 EE + + + + ++ L S H+DL +N+L+ +ADF + Sbjct: 151 EEQMTFKDLVSCTYQLARGMEYL-ASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN 209 Query: 513 -----------------DPQEV-------KRDLEDLGRLVLYVVKKGSIS---------F 539 P+ + + D+ G L+ + G F Sbjct: 210 IDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 269 Query: 540 EDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGH 583 + LK + + E ++ +H R L+ Sbjct: 270 KLLKEGHRMDKPA-NCTNELYMMMRDCWHAVPSQRPTFKQLVED 312 >6CTH-A nrPDB Length = 309 Score = 84.8 bits (208), Expect = 1e-16, Method: Composition-based stats. Identities = 44/229 (19%), Positives = 77/229 (33%), Gaps = 40/229 (17%) Query: 358 IGKLKFFIDEKYKIADTSEGGIYLGFYEKQE--VAVKTFCEGSPRAQRE----VSCLQSS 411 + K+ + + K+ + G +Y GF + +AVK S + +E V + Sbjct: 10 LAKVTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRL 69 Query: 412 RENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 471 R + +LV G RG L + LD H + E ++ + A Sbjct: 70 R-HKNLVKLIGWCHERGELMLVYEFMANGS---LDSHIFKGKSLLTWEVRYRIVKDLASA 125 Query: 472 VQELHL--SCGYTHQDLQPQNILIDSKKAAHLADFDKSIK-------------------- 509 + LH H+D++ NI++DS A L DF + Sbjct: 126 LLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMA 185 Query: 510 ---WAGDPQEVKRDLEDLGRLVLYVVKKGS----ISFEDLKAQSNEEVV 551 + + D+ G + L + G FE+ +A V Sbjct: 186 PECLSSGKASKESDVYSFGVVAL-EIASGRRSIEPKFEESEALLLVPWV 233 >5HVK-A nrPDB Length = 315 Score = 84.4 bits (207), Expect = 2e-16, Method: Composition-based stats. Identities = 50/327 (15%), Positives = 92/327 (28%), Gaps = 86/327 (26%) Query: 351 HRIYRP---MIGKL--KFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPR-AQRE 404 HRI+RP + G++ K + K+ G + + + F E + R +E Sbjct: 8 HRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMV------MKELIRFDEETQRTFLKE 61 Query: 405 VSCLQSSRENSHLVTFYGSESHRGHLFVCVTLC-EQTLEACLDVHRGEDVENEEDEFARN 463 V ++ E+ +++ F G L TL + + ++ FA++ Sbjct: 62 VKVMRCL-EHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKD 120 Query: 464 VLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS---------------- 507 I + LH S H++L N L+ K +ADF + Sbjct: 121 ----IASGMAYLH-SMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSL 175 Query: 508 --------IKWAGDP------------QEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSN 547 G+P + K D+ G ++ ++ G ++ + Sbjct: 176 KKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEII--GRVNADPDYLPRT 233 Query: 548 EE-------------VVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYR 594 + P + R R F E Sbjct: 234 MDFGLNVRGFLDRYCPPNCPPS--FFPITVRCCDLDPEKRPS---------FVKLEHWLE 282 Query: 595 TLRNVGNESDIKTRKSESEILRLLQPG 621 TL + L L G Sbjct: 283 TL-----RMHLAGHLPLGPQLEQLDRG 304 >3GQL-A nrPDB Length = 326 Score = 84.0 bits (206), Expect = 2e-16, Method: Composition-based stats. Identities = 38/280 (13%), Positives = 81/280 (28%), Gaps = 65/280 (23%) Query: 367 EKYKIADTSEGGIYLGFYEKQ-------------EVAVKTFCEGSPRAQ-----REVSCL 408 ++ + G + + +VAVK + E+ + Sbjct: 28 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 87 Query: 409 QSSRENSHLVTFYGSESHRGHLFVCVTLCEQT-LEACLDVHRG-------EDVENEEDEF 460 + ++ +++ G+ + G L+V V + L L R N E++ Sbjct: 88 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQL 147 Query: 461 AR----NVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE 516 + + + + ++ L S H+DL +N+L+ +ADF + Sbjct: 148 SSKDLVSCAYQVARGMEYL-ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 206 Query: 517 VK------------------------RDLEDLGRLVLYVVKKGSIS---------FEDLK 543 K D+ G L+ + G F+ LK Sbjct: 207 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 266 Query: 544 AQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGH 583 + + E ++ +H R L+ Sbjct: 267 EGHRMDKPSNCTN-ELYMMMRDCWHAVPSQRPTFKQLVED 305 >4XLV-A nrPDB Length = 328 Score = 83.6 bits (205), Expect = 3e-16, Method: Composition-based stats. Identities = 47/276 (17%), Positives = 88/276 (31%), Gaps = 64/276 (23%) Query: 370 KIADTSEGGIYLGFYE-------KQEVAVKTFCEGSPRAQR-----EVSCLQSSRENSHL 417 ++ S G +Y G + VAVKT E + +R E S ++ + H+ Sbjct: 46 ELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCH-HV 104 Query: 418 VTFYGSESHRGHLFVCVTLC-EQTLEACLDVHRGED-----VENEEDEFARNVLSSIFKA 471 V G S V + L L++ L R E + + + I Sbjct: 105 VRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADG 164 Query: 472 VQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVK------------- 518 + L + + H+DL +N ++ + DF + K Sbjct: 165 MAYL-NAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAP 223 Query: 519 -----------RDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPD----------- 556 D+ G ++ + ++ L SNE+V++ D Sbjct: 224 ESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGL---SNEQVLKFVMDGGYLDQPDNCP 280 Query: 557 EETKDLIHRLFHPGEHVRDCLSDLLG------HPFF 586 E DL+ + ++R +++ HP F Sbjct: 281 ERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSF 316 >5A46-A nrPDB Length = 386 Score = 83.6 bits (205), Expect = 3e-16, Method: Composition-based stats. Identities = 38/280 (13%), Positives = 81/280 (28%), Gaps = 65/280 (23%) Query: 367 EKYKIADTSEGGIYLGFYEKQ-------------EVAVKTFCEGSPRAQ-----REVSCL 408 ++ + G + + +VAVK + E+ + Sbjct: 40 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 99 Query: 409 QSSRENSHLVTFYGSESHRGHLFVCVTLCEQT-LEACLDVHRG-------EDVENEEDEF 460 + ++ +++ G+ + G L+V V + L L R N E++ Sbjct: 100 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQL 159 Query: 461 AR----NVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE 516 + + + + ++ L S H+DL +N+L+ +ADF + Sbjct: 160 SSKDLVSCAYQVARGMEYL-ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 218 Query: 517 VK------------------------RDLEDLGRLVLYVVKKGSIS---------FEDLK 543 K D+ G L+ + G F+ LK Sbjct: 219 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 278 Query: 544 AQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGH 583 + + E ++ +H R L+ Sbjct: 279 EGHRMDKPS-NCTNELYMMMRDCWHAVPSQRPTFKQLVED 317 >2WO6-A nrPDB Length = 382 Score = 82.8 bits (203), Expect = 4e-16, Method: Composition-based stats. Identities = 46/259 (17%), Positives = 82/259 (31%), Gaps = 52/259 (20%) Query: 367 EKYKIADTSEGGIYLGFYEKQE------VAVKTFCEG---SPRAQREVSCLQSSRENSHL 417 ++Y+I G + + + VA+K +AQ EV L+ ++ Sbjct: 54 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 113 Query: 418 VTFYGSESHRGHLF-----VCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAV 472 + +Y R +F + + L D+ R + R + A+ Sbjct: 114 MKYYIVHLKRHFMFRNHLCLVFEMLSYNL---YDLLRNTNFRGVSLNLTRKFAQQMCTAL 170 Query: 473 QELHL-SCGYTHQDLQPQNILIDSKK--AAHLADFDKSIKWA------------------ 511 L H DL+P+NIL+ + K A + DF S + Sbjct: 171 LFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVL 230 Query: 512 -GDPQEVKRDLEDLGRLVLYVVKKGSISF----EDLKAQSNEEVVQLSPDEETKDLIHRL 566 G P ++ D+ LG +L + G F E + EV+ + P + Sbjct: 231 LGMPYDLAIDMWSLGC-ILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA--------HI 281 Query: 567 FHPGEHVRDCLSDLLGHPF 585 R L + Sbjct: 282 LDQAPKARKFFEKLPDGTW 300 Score = 35.1 bits (79), Expect = 0.12, Method: Composition-based stats. Identities = 11/43 (25%), Positives = 17/43 (39%) Query: 544 AQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 ++ E ++ + KDLI R+ R L H FF Sbjct: 334 RRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 376 >2W1I-A nrPDB Length = 326 Score = 82.8 bits (203), Expect = 5e-16, Method: Composition-based stats. Identities = 44/272 (16%), Positives = 88/272 (32%), Gaps = 67/272 (24%) Query: 370 KIADTSEGGIYLGFYEK------QEVAVKTF----CEGSPRAQREVSCLQSSRENSHLVT 419 ++ + G + + Y+ + VAVK E +RE+ L+ S ++ ++V Sbjct: 48 QLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILK-SLQHDNIVK 106 Query: 420 F--YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL 477 + + R +L + + E +++ + S I K ++ L Sbjct: 107 YKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLL---QYTSQICKGMEYL-G 162 Query: 478 SCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE--------------------- 516 + Y H+DL +NIL++++ + DF + D + Sbjct: 163 TKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTE 222 Query: 517 ----VKRDLEDLGRLVL----YVVKKGSIS--------------------FEDLKAQSNE 548 V D+ G ++ Y+ K S E LK Sbjct: 223 SKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRL 282 Query: 549 EVVQLSPDEETKDLIHRLFHPGEHVRDCLSDL 580 PDE ++ ++ + R DL Sbjct: 283 PRPDGCPDEIY-MIMTECWNNNVNQRPSFRDL 313 >4LRM-A nrPDB Length = 334 Score = 82.8 bits (203), Expect = 5e-16, Method: Composition-based stats. Identities = 50/296 (16%), Positives = 99/296 (33%), Gaps = 56/296 (18%) Query: 355 RPMIGKLKFFIDEKYKI-ADTSEGGIYLGFYEKQ------EVAVKTFCE-GSPRAQREV- 405 + ++ LK +K K+ + G +Y G + + VA+K E SP+A +E+ Sbjct: 10 QALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEIL 69 Query: 406 ---SCLQSSR--ENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEF 460 + S N H+ G + + L CL + E +N ++ Sbjct: 70 DEAYVMASVDNPGNPHVCRLLGICLT-STVQLITQLMPFG---CLLDYVREHKDNIGSQY 125 Query: 461 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV--- 517 N I K + L H+DL +N+L+ + + + DF + + +E Sbjct: 126 LLNWCVQIAKGMNYL-EDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE 184 Query: 518 ---------------------KRDLEDLGRLVLYVVKKGSISFEDL----------KAQS 546 + D+ G V ++ GS ++ + K + Sbjct: 185 GGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGER 244 Query: 547 NEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNE 602 + + D ++ + + R +L+ F R L G+E Sbjct: 245 LPQPPICTID--VYMIMVKCWMIDADSRPKFRELII-EFSKMARDPQRYLVIQGDE 297 >2Y4I-B nrPDB Length = 319 Score = 82.4 bits (202), Expect = 6e-16, Method: Composition-based stats. Identities = 46/270 (17%), Positives = 88/270 (32%), Gaps = 61/270 (22%) Query: 367 EKYKIADTSEGGIYLGFYEKQ---EVAVKTFC------EGSPRAQREVSCLQSSRENSHL 417 E+ +I + G + Y + EVA++ + +REV + +R + ++ Sbjct: 33 EQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTR-HENV 91 Query: 418 VTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL 477 V F G+ HL + +LC+ V R + + ++ R + I K + LH Sbjct: 92 VLFMGACMSPPHLAIITSLCKG--RTLYSVVRDAKIVLDVNK-TRQIAQEIVKGMGYLHA 148 Query: 478 SCGYTHQDLQPQNILIDSKKAAHLADFD-------------------------------- 505 G H+DL+ +N+ D + DF Sbjct: 149 K-GILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEII 206 Query: 506 --KSIKWAGD--PQEVKRDLEDLGRLVLYVVKKGSISF---------EDLKAQSNEEVVQ 552 S D P D+ LG + Y + F + + Q Sbjct: 207 RQLSPDTEEDKLPFSKHSDVFALG-TIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQ 265 Query: 553 LSPDEETKDLIHRLFHPGEHVRDCLSDLLG 582 + +E D++ + + R + L+ Sbjct: 266 IGMGKEISDILLFCWAFEQEERPTFTKLMD 295 >3IO7-A nrPDB Length = 313 Score = 82.4 bits (202), Expect = 7e-16, Method: Composition-based stats. Identities = 44/272 (16%), Positives = 88/272 (32%), Gaps = 67/272 (24%) Query: 370 KIADTSEGGIYLGFYEK------QEVAVKTFC----EGSPRAQREVSCLQSSRENSHLVT 419 ++ + G + + Y+ + VAVK E +RE+ L+ S ++ ++V Sbjct: 35 QLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILK-SLQHDNIVK 93 Query: 420 F--YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL 477 + + R +L + + E +++ + S I K ++ L Sbjct: 94 YKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLL---QYTSQICKGMEYL-G 149 Query: 478 SCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE--------------------- 516 + Y H+DL +NIL++++ + DF + D + Sbjct: 150 TKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTE 209 Query: 517 ----VKRDLEDLGRLVL----YVVKKGSIS--------------------FEDLKAQSNE 548 V D+ G ++ Y+ K S E LK Sbjct: 210 SKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRL 269 Query: 549 EVVQLSPDEETKDLIHRLFHPGEHVRDCLSDL 580 PDE ++ ++ + R DL Sbjct: 270 PRPDGCPDEIY-MIMTECWNNNVNQRPSFRDL 300 >5ZTN-A nrPDB Length = 429 Score = 82.4 bits (202), Expect = 7e-16, Method: Composition-based stats. Identities = 45/319 (14%), Positives = 87/319 (27%), Gaps = 104/319 (32%) Query: 368 KYKIADTSEGGIYLGFYEK------QEVAVKTFCEGSPR---AQREVSCLQSSRENS--- 415 +Y++ G + + Q VA+K A E+ L+ R+ Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDN 157 Query: 416 --HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQ 473 +++ + + R H+ + L L ++ + + R SI + + Sbjct: 158 TMNVIHMLENFTFRNHICMTFELLSMNL---YELIKKNKFQGFSLPLVRKFAHSILQCLD 214 Query: 474 ELHLSCGYTHQDLQPQNILIDSKK--AAHLADFDK-SIKWAGDPQEVKR----------- 519 LH + H DL+P+NIL+ + + DF + ++ Sbjct: 215 ALHKN-RIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILG 273 Query: 520 -------DLEDLGRLVL-----------------------------------------YV 531 D+ LG ++ +V Sbjct: 274 ARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFV 333 Query: 532 VKKGSISFEDLKAQSNEEVV-----------QLSP-------------DEETKDLIHRLF 567 KG + + S+ VV + P D D + + Sbjct: 334 SSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCL 393 Query: 568 HPGEHVRDCLSDLLGHPFF 586 VR L HP+ Sbjct: 394 EWDPAVRMTPGQALRHPWL 412 >4CRS-A nrPDB Length = 341 Score = 82.1 bits (201), Expect = 9e-16, Method: Composition-based stats. Identities = 47/245 (19%), Positives = 84/245 (34%), Gaps = 50/245 (20%) Query: 385 EKQEVAVKTFCEGSPRAQREVSCLQS---------SRENSHLVTFYGSESHRGHLFVCVT 435 + A+K +G A+ EV L S + LV + + H+ + Sbjct: 36 TNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVME 95 Query: 436 LCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDS 495 L +H DV +E A + + +Q LH ++DL+ N+L+D+ Sbjct: 96 YAAGG---DLMMHIHTDVFSEPR--AVFYAACVVLGLQYLHE-HKIVYRDLKLDNLLLDT 149 Query: 496 KKAAHLADFDKSIK----------WAGDPQEV------------KRDLEDLGRLVLYVVK 533 + +ADF + + G P+ + D LG +++Y + Sbjct: 150 EGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLG-VLIYEML 208 Query: 534 KGSISF--ED-----LKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSD-----LL 581 G F +D ++E E ++ RL R S+ + Sbjct: 209 VGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVK 268 Query: 582 GHPFF 586 HPFF Sbjct: 269 KHPFF 273 >5UIU-A nrPDB Length = 323 Score = 82.1 bits (201), Expect = 9e-16, Method: Composition-based stats. Identities = 35/195 (17%), Positives = 66/195 (33%), Gaps = 36/195 (18%) Query: 370 KIADTSEGGIYLGFYEKQEVAVKTFC--------EGSPRAQREVSCLQSSRENSHLVTFY 421 K+ + G +Y G+ VAVK E + +E+ + ++ +LV Sbjct: 54 KMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC-QHENLVELL 112 Query: 422 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSS-IFKAVQELHLSCG 480 G S L + + LD D R ++ + LH + Sbjct: 113 GFSSDGDDLCLVYVYMPNG--SLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH 170 Query: 481 YTHQDLQPQNILIDSKKAAHLADFDKSI------------KWAGDPQEV----------- 517 H+D++ NIL+D A ++DF + + G + Sbjct: 171 I-HRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITP 229 Query: 518 KRDLEDLGRLVLYVV 532 K D+ G ++L ++ Sbjct: 230 KSDIYSFGVVLLEII 244 >5TOS-A nrPDB Length = 395 Score = 81.7 bits (200), Expect = 1e-15, Method: Composition-based stats. Identities = 42/280 (15%), Positives = 83/280 (29%), Gaps = 65/280 (23%) Query: 367 EKYKIADTSEGGIYLGFYEKQ-----------EVAVKTFCEGSPRAQRE----VSCLQSS 411 I + G ++ G+ ++ +AVK + + RE ++ L Sbjct: 69 PDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQL 128 Query: 412 RENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 471 + +LV G H + ++ RG + NV K Sbjct: 129 S-HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 Query: 472 VQELHLS-CGYTHQDLQPQNILIDSKKAAHLADFDKSIK-WAGDPQEV------------ 517 + LH ++D++ NIL+D+ A L+DF + GD V Sbjct: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAA 247 Query: 518 -----------KRDLEDLGRLVLYVVK-----------------KGSISFEDLKAQS--- 546 + D+ G L+L ++ + + K + Sbjct: 248 PEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLI 307 Query: 547 --NEEVVQLSPDEETKD--LIHRLFHPGEHVRDCLSDLLG 582 N Q P+E + + + R + ++ Sbjct: 308 VDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 >3I81-A nrPDB Length = 315 Score = 81.7 bits (200), Expect = 1e-15, Method: Composition-based stats. Identities = 40/290 (13%), Positives = 84/290 (28%), Gaps = 54/290 (18%) Query: 373 DTSEGGIYLGFYEKQE---VAVKTFCEGSPRAQR-----EVSCLQSSRENSHLVTFYGSE 424 G+ G + + VA+KT E + +R E S ++ + H+V G Sbjct: 32 GMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVV 90 Query: 425 SHRGHLFVCVTLC-EQTLEACLDVHRGED-----VENEEDEFARNVLSSIFKAVQELHLS 478 S V + L L++ L R E + + I + L+ + Sbjct: 91 SQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNAN 150 Query: 479 CGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVK-------------------- 518 + H+DL +N ++ + DF + K Sbjct: 151 -KFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGV 209 Query: 519 ----RDLEDLGRLVLYVVKKGSISFEDLKAQS---------NEEVVQLSPDEETKDLIHR 565 D+ G ++ + ++ L + + PD +L+ Sbjct: 210 FTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLF-ELMRM 268 Query: 566 LFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEIL 615 + +R +++ E R V + + + +L Sbjct: 269 CWQYNPKMRPSFLEIIS----SIKEEMEPGFREVSFYYSEENKMENNPVL 314 >1D9S-A nrPDB Length = 136 Score = 81.7 bits (200), Expect = 1e-15, Method: Composition-based stats. Identities = 36/117 (30%), Positives = 50/117 (42%), Gaps = 3/117 (2%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88 L A V+ V+QLLE GA+ N G P+ + M + ELLL HGA+P Sbjct: 16 LATAAARGQVETVRQLLEAGADPNALNRFGRR-PIQV-MMMGSAQVAELLLLHGAEPNCA 73 Query: 89 KKNGAT-PFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFL 144 T P AA G + L + GA ++ CD +G A G ++L Sbjct: 74 DPATLTRPVHDAAREGFLDTLVVLHRAGARLDVCDAWGRLPVDLAEEQGHRDIARYL 130 Score = 60.1 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 30/143 (20%), Positives = 53/143 (37%), Gaps = 15/143 (10%) Query: 116 ADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDA 175 ++ AA G+V+ ++ L + GA+ N L + G + Sbjct: 3 PGIHMLGGSSDAGLATAAARGQVETVRQLLEAGADPNA----------LNRFGRRPIQV- 51 Query: 176 AEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVR 235 G +V ++LL GA+ N D +H +L GA ++V Sbjct: 52 MMMGSAQVAELLLLH-GAEPNCADPATLTRPVHDAA---REGFLDTLVVLHRAGARLDVC 107 Query: 236 GERGKTPLILAVEKKHLGLVQRL 258 G+ P+ LA E+ H + + L Sbjct: 108 DAWGRLPVDLAEEQGHRDIARYL 130 Score = 52.0 bits (123), Expect = 9e-07, Method: Composition-based stats. Identities = 29/128 (22%), Positives = 52/128 (40%), Gaps = 14/128 (10%) Query: 231 DVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAE 290 +++ G L A + + V++LLE + N + G+ + + + + ++AE Sbjct: 4 GIHMLGGSSDAGLATAAARGQVETVRQLLE-AGADPNALNRFGRRPIQV-MMMGSAQVAE 61 Query: 291 LLCKRGASTDCGD-------LVMTARRNYDHSLVKVLLSHGAKED----FHPPAEDWKPQ 339 LL GA +C D + AR + +LV VL GA+ D + D + Sbjct: 62 LLLLHGAEPNCADPATLTRPVHDAAREGFLDTLV-VLHRAGARLDVCDAWGRLPVDLAEE 120 Query: 340 SSHWGAAL 347 H A Sbjct: 121 QGHRDIAR 128 Score = 38.1 bits (87), Expect = 0.013, Method: Composition-based stats. Identities = 11/52 (21%), Positives = 20/52 (38%), Gaps = 1/52 (1%) Query: 27 HLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELL 78 + A + +D + L GA ++ + G P+ A + DI L Sbjct: 80 RPVHDAAREGFLDTLVVLHRAGARLDVCD-AWGRLPVDLAEEQGHRDIARYL 130 >5VDK-A nrPDB Length = 297 Score = 81.3 bits (199), Expect = 1e-15, Method: Composition-based stats. Identities = 42/269 (15%), Positives = 78/269 (28%), Gaps = 57/269 (21%) Query: 370 KIADTSEGGIYLGFYEKQEV--AVKTFCEGSPRAQREVSCLQSSREN------SHLVTFY 421 KI G +Y A+K + E S L + H+V +Y Sbjct: 22 KIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHHPHVVRYY 81 Query: 422 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 S + H+ + C + + E+ +++L I + +H S Sbjct: 82 SSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNS-SM 140 Query: 482 THQDLQPQNILIDSKKAA-----------------------HLADFDKSIKW------AG 512 H D++P NI I K + + D + G Sbjct: 141 VHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINKPKVEEG 200 Query: 513 DPQEV-------------KRDLEDLGRLVLYVVKKGSIS-----FEDLKAQSNEEVVQLS 554 D + + K D+ LG + S+ + ++ + +V Q Sbjct: 201 DSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHHIRKGNFPDVPQ-E 259 Query: 555 PDEETKDLIHRLFHPGEHVRDCLSDLLGH 583 E L+ + P R + L + Sbjct: 260 LSESFSSLLKNMIQPDAEQRPSAAALARN 288 >5Y86-A nrPDB Length = 588 Score = 80.9 bits (198), Expect = 2e-15, Method: Composition-based stats. Identities = 46/336 (13%), Positives = 95/336 (28%), Gaps = 105/336 (31%) Query: 368 KYKIADTSEGGIYLGFYE------KQEVAVKTFCEGSPR---AQREVSCLQSSRENS--- 415 +Y++ G + +Q VA+K A E+ L+ ++ Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 Query: 416 --HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQ 473 +++ S + R H+ + L L ++ + + + R SI +++ Sbjct: 268 SMNVIHMLESFTFRNHVCMAFELLSIDL---YELIKKNKFQGFSVQLVRKFAQSILQSLD 324 Query: 474 ELHLSCGYTHQDLQPQNILIDSKK--AAHLADFDK-SIKWA------------------G 512 LH + H DL+P+NIL+ + + DF ++ G Sbjct: 325 ALHKN-KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG 383 Query: 513 DPQEVKRDLEDLGRLV-----------------------------------------LYV 531 D+ G ++ ++ Sbjct: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443 Query: 532 VKKGSISFEDLKAQSNEEVV-----------QLSP-------------DEETKDLIHRLF 567 KG + + Q++ VV + P D + + R Sbjct: 444 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL 503 Query: 568 HPGEHVRDCLSDLLGHPFFW-TWESRYRTLRNVGNE 602 H R + L HP+ + T+ V + Sbjct: 504 HWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGK 539 >3G0E-A nrPDB Length = 336 Score = 80.9 bits (198), Expect = 2e-15, Method: Composition-based stats. Identities = 37/246 (15%), Positives = 70/246 (28%), Gaps = 53/246 (21%) Query: 389 VAVKTFCEGSPRAQRE-----VSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEA 443 VAVK + +RE + L + ++V G+ + G V C Sbjct: 79 VAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLL 138 Query: 444 CLDVHRGEDVENEEDEFA--------------RNVLSSIFKAVQELHLSCGYTHQDLQPQ 489 + + + A + + K + L S H+DL + Sbjct: 139 NFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFL-ASKNCIHRDLAAR 197 Query: 490 NILIDSKKAAHLADFDKSIKWAGDPQEV------------------------KRDLEDLG 525 NIL+ + + DF + D V + D+ G Sbjct: 198 NILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYG 257 Query: 526 RLVLYVVKKGSISFEDLKAQSNEEVV------QLSPD---EETKDLIHRLFHPGEHVRDC 576 + + GS + + S + LSP+ E D++ + R Sbjct: 258 IFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPT 317 Query: 577 LSDLLG 582 ++ Sbjct: 318 FKQIVQ 323 >4CRL-A nrPDB Length = 406 Score = 80.5 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 44/313 (14%), Positives = 91/313 (29%), Gaps = 97/313 (30%) Query: 370 KIADTSEGGIYLGFYEKQEV----AVKTF--CEGSPRAQREVSCLQSSRENSHLVTFYGS 423 K+ + G +Y + + A+K S A RE++ L+ ++ ++++ Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLREL-KHPNVISLQKV 87 Query: 424 ESH--RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFAR----NVLSSIFKAVQELHL 477 +++ E L + HR + + R ++L I + LH Sbjct: 88 FLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHA 147 Query: 478 SCGYTHQDLQPQNILI----DSKKAAHLADFDKSIKWAG--------DP----------- 514 + H+DL+P NIL+ + +AD + + DP Sbjct: 148 NW-VLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPE 206 Query: 515 -------QEVKRDLEDLGRLVLYVVKK-----------------------------GSIS 538 D+ +G + ++ G + Sbjct: 207 LLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPA 266 Query: 539 ---FEDLKAQSNE---------------------EVVQLSPDEETKDLIHRLFHPGEHVR 574 +ED+K E ++ PD + L+ +L R Sbjct: 267 DKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKR 326 Query: 575 DCLSDLLGHPFFW 587 + P+F Sbjct: 327 ITSEQAMQDPYFL 339 >5LPZ-A nrPDB Length = 332 Score = 80.5 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 40/249 (16%), Positives = 72/249 (28%), Gaps = 37/249 (14%) Query: 368 KYKIADTSEGGIYLGFYEK-QEVAVKTFCEGSPRAQREVSCLQSSRE---NSHLVTFYGS 423 I G +Y + VA+K S + RE + + +LV G Sbjct: 22 DSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGY 81 Query: 424 ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG--Y 481 + + + + R + + + LH +C Sbjct: 82 CKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHI 141 Query: 482 THQDLQPQNILIDSKKAAHLADFDKSI------------KWAGDPQEV------------ 517 H+D++ N+L+D A ++DF + AG P V Sbjct: 142 IHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCST 201 Query: 518 KRDLEDLGRLVLYVVKKGSISFEDLKAQSN--EEVVQLSPDEETKDLIH-RLFHPGEHVR 574 K D+ G ++L + G + N V+ D+ L + Sbjct: 202 KGDVYSYGVVLL-ELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELMKEDPALE 260 Query: 575 DCLSDLLGH 583 +LL H Sbjct: 261 I---ELLQH 266 >4K33-A nrPDB Length = 325 Score = 80.5 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 36/279 (12%), Positives = 78/279 (27%), Gaps = 65/279 (23%) Query: 368 KYKIADTSEGGIYLGFYEKQ-------------EVAVKTFCEGSPRAQ-----REVSCLQ 409 + + G + + VAVK + + E+ ++ Sbjct: 37 RLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMK 96 Query: 410 SSRENSHLVTFYGSESHRGHLFVCVTLCEQT-LEACLDVHRG--------EDVENEEDEF 460 ++ +++ G+ + G L+V V + L L R EE Sbjct: 97 MIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQLT 156 Query: 461 AR---NVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV 517 + + + + ++ L S H+DL +N+L+ +ADF + Sbjct: 157 FKDLVSCAYQVARGMEYL-ASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYK 215 Query: 518 K------------------------RDLEDLGRLVLYVVKKGSIS---------FEDLKA 544 + D+ G L+ + G F+ LK Sbjct: 216 ETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE 275 Query: 545 QSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGH 583 + + + ++ +H R L+ Sbjct: 276 GHRMDKPA-NCTHDLYMIMRECWHAAPSQRPTFKQLVED 313 >4HVI-A nrPDB Length = 314 Score = 80.5 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 51/273 (18%), Positives = 84/273 (30%), Gaps = 70/273 (25%) Query: 370 KIADTSEGGIYLGFYEKQE------VAVKTFCEGSPRAQR----EVSCLQSSRENSHLVT 419 ++ + G + L Y+ VAVK P QR E+ L++ + +V Sbjct: 17 QLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALH-SDFIVK 75 Query: 420 FYGSESH--RGHLFVCVTLCE-QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 + G R L + + L L HR + ++ S I K ++ L Sbjct: 76 YRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYS----SQICKGMEYL- 130 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV------------------- 517 S H+DL +NIL++S+ +ADF + D Sbjct: 131 GSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLS 190 Query: 518 ------KRDLEDLGRLVL----YVVKKGSISFEDLKA--------------------QSN 547 + D+ G ++ Y K S S E L+ Q Sbjct: 191 DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQRL 250 Query: 548 EEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDL 580 E +L+ + P R S L Sbjct: 251 PAPPACP--AEVHELMKLCWAPSPQDRPSFSAL 281 >5X8I-B nrPDB Length = 346 Score = 80.5 bits (197), Expect = 3e-15, Method: Composition-based stats. Identities = 56/331 (16%), Positives = 89/331 (26%), Gaps = 107/331 (32%) Query: 364 FIDEKYKIADTSEGGIYLGFYE-------KQEVAVKTFCEG---SPRAQREVSCLQSSRE 413 + +Y+I DT G + E + VAVK A+ E+ L+ Sbjct: 10 VLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNT 69 Query: 414 -NSH----LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 + + V H GH+ + L + D + + R + I Sbjct: 70 TDPNSTFRCVQMLEWFEHHGHICIVFELLGLST---YDFIKENGFLPFRLDHIRKMAYQI 126 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDS-------------------KKAAHLADFDKSI- 508 K+V LH S TH DL+P+NIL + DF + Sbjct: 127 CKSVNFLH-SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY 185 Query: 509 ------KWAGDPQEVK------------RDLEDLGRLVL-YVVKKGSISFEDLK------ 543 D+ +G +++ Y + D K Sbjct: 186 DDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMM 245 Query: 544 ----------------------------------------AQSNEEVVQLSPDEETK--- 560 A + LS D E + Sbjct: 246 ERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLF 305 Query: 561 DLIHRLFHPGEHVRDCLSDLLGHPFFWTWES 591 DLI ++ R L + L HPFF + Sbjct: 306 DLIQKMLEYDPAKRITLREALKHPFFDLLKK 336 >4OTD-A nrPDB Length = 341 Score = 80.5 bits (197), Expect = 3e-15, Method: Composition-based stats. Identities = 56/302 (18%), Positives = 98/302 (32%), Gaps = 64/302 (21%) Query: 367 EKYKIADTSEGGIYLGFYEK------QEVAVKTFCEGSPRAQREVSCLQS---------S 411 E +K G + + A+K +G A+ EV L S Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 71 Query: 412 RENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 471 + LV +G H+ + L +H DV +E A + + Sbjct: 72 AGHPFLVNLFGCFQTPEHVCFVMEYSAGG---DLMLHIHSDVFSEPR--AIFYSACVVLG 126 Query: 472 VQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK----------WAGDPQEV---- 517 +Q LH ++DL+ N+L+D++ +ADF + + G P+ + Sbjct: 127 LQFLHE-HKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 185 Query: 518 --------KRDLEDLGRLVLYVVKKGSISF--ED-----LKAQSNEEVVQLSPDEETKDL 562 D LG ++LY + G F +D ++E E + Sbjct: 186 LTDTSYTRAVDWWGLG-VLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGI 244 Query: 563 IHRLFHPGEHVRDCLSD-----LLGHPFFWT--WESRYR------TLRNVGNESDIKTRK 609 + RL R S+ + PFF T WE+ + + +D+ Sbjct: 245 MRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFD 304 Query: 610 SE 611 E Sbjct: 305 EE 306 >6OO7-A nrPDB Length = 786 Score = 80.1 bits (196), Expect = 3e-15, Method: Composition-based stats. Identities = 43/203 (21%), Positives = 81/203 (39%), Gaps = 31/203 (15%) Query: 91 NGATPFILAA---IAGSVKLLKLFLS-----------KGADVNECDFYGFTAFMEAAVYG 136 G T + A G ++ L A + + G +A A Sbjct: 114 TGKTCLMKAVLNLQDGVNACIQPLLEIDRDSGNPQPLVNAQCTDEYYRGHSALHIAIEKR 173 Query: 137 KVKALKFLYKRGANVNLRR---KTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEM-- 191 ++ +K L + GANV+ + +++Q+ G L AA +V+ LL+ Sbjct: 174 SLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQWDVVNYLLENPHQ 233 Query: 192 GADVNACDNMGRNALIHALLSSDD--SDVEAITHL---LLDHGA----DVNVR---GERG 239 A + A D++G L ++ +DD + + + LL GA +V + G Sbjct: 234 PASLQAQDSLGNTVLHALVMIADDSAENSALVVRMYDGLLQAGARLCPNVQLEGIPNLEG 293 Query: 240 KTPLILAVEKKHLGLVQRLLEQE 262 TPL LA ++ + + + +L++E Sbjct: 294 LTPLKLAAKEGKIEIFKHILQRE 316 Score = 62.0 bits (149), Expect = 9e-10, Method: Composition-based stats. Identities = 46/202 (22%), Positives = 72/202 (35%), Gaps = 41/202 (20%) Query: 27 HLLIKAVQNEDVDL---VQQLLEGGAN-------VNFQEEEG---GWTPLHNAVQMSRED 73 L+KAV N + +Q LLE + VN Q + G + LH A++ Sbjct: 117 TCLMKAVLNLQDGVNACIQPLLEIDRDSGNPQPLVNAQCTDEYYRGHSALHIAIEKRSLQ 176 Query: 74 IVELLLRHGADPVLRKKN-------------GATPFILAAIAGSVKLLKLFLSK---GAD 117 V+LL+ +GA+ + G P LAA ++ L A Sbjct: 177 CVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQWDVVNYLLENPHQPAS 236 Query: 118 VNECDFYGFTAFM----EAAVYGKVKALKF-----LYKRGANVNLRRKTKEDQERLRKGG 168 + D G T A + AL L + GA + + + G Sbjct: 237 LQAQDSLGNTVLHALVMIADDSAENSALVVRMYDGLLQAGARLCPNVQLEGIP---NLEG 293 Query: 169 ATALMDAAEKGHVEVLKILLDE 190 T L AA++G +E+ K +L Sbjct: 294 LTPLKLAAKEGKIEIFKHILQR 315 Score = 60.9 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 49/216 (22%), Positives = 82/216 (37%), Gaps = 34/216 (15%) Query: 4 RDHNNPQEGPTSSSGRRAAVEDNH-LLIKAVQNEDVDLVQQLLEGGANVN-------FQE 55 RD NPQ P ++ H L A++ + V+ L+E GANV+ FQ+ Sbjct: 142 RDSGNPQ--PLVNAQCTDEYYRGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQK 199 Query: 56 EEG-----GWTPLHNAVQMSREDIVELLLRHG---ADPVLRKKNGATPFI----LA--AI 101 + G PL A + D+V LL + A + G T +A + Sbjct: 200 NQDTCFYFGELPLSLAACTKQWDVVNYLLENPHQPASLQAQDSLGNTVLHALVMIADDSA 259 Query: 102 AGSVKLLKL---FLSKGADV--NEC-----DFYGFTAFMEAAVYGKVKALKFLYKRGANV 151 S ++++ L GA + N + G T AA GK++ K + +R + Sbjct: 260 ENSALVVRMYDGLLQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQREFSA 319 Query: 152 NLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKIL 187 + +++ E +L D A E +L Sbjct: 320 PCQSLSRKFTEWCYGPVRVSLYDLASVDSWEENSVL 355 Score = 38.5 bits (88), Expect = 0.010, Method: Composition-based stats. Identities = 22/83 (26%), Positives = 36/83 (43%), Gaps = 13/83 (15%) Query: 233 NVRGERGKTPLILAV---EKKHLGLVQRLLEQEHIE------INDTDSD----GKTALLL 279 G GKT L+ AV + +Q LLE + +N +D G +AL + Sbjct: 109 YTEGSTGKTCLMKAVLNLQDGVNACIQPLLEIDRDSGNPQPLVNAQCTDEYYRGHSALHI 168 Query: 280 AVELKLKKIAELLCKRGASTDCG 302 A+E + + +LL + GA+ Sbjct: 169 AIEKRSLQCVKLLVENGANVHAK 191 >5C26-A nrPDB Length = 299 Score = 80.1 bits (196), Expect = 3e-15, Method: Composition-based stats. Identities = 36/261 (13%), Positives = 83/261 (31%), Gaps = 48/261 (18%) Query: 362 KFFIDEKYKIADTSEGGIYLGFYE------KQEVAVKTFCEGSPRAQREVSC---LQSSR 412 K E ++ + G + G+Y+ V + P + E+ + Sbjct: 26 KLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL 85 Query: 413 ENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAV 472 +N ++V G + + + + E L+ + ++ ++ ++ + + Sbjct: 86 DNPYIVRMIGICEAESWM-LVMEMAELGP---LNKYLQQNRHVKDKNI-IELVHQVSMGM 140 Query: 473 QELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV--------------- 517 + L S + H+DL +N+L+ ++ A ++DF S D Sbjct: 141 KYLEES-NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 199 Query: 518 ----------KRDLEDLGRLVLYVVKKGSISFEDLKAQ------SNEEVVQLSPD--EET 559 K D+ G L+ G + +K E + E Sbjct: 200 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM 259 Query: 560 KDLIHRLFHPGEHVRDCLSDL 580 DL++ + R + + Sbjct: 260 YDLMNLCWTYDVENRPGFAAV 280 >2OGV-A nrPDB Length = 317 Score = 80.1 bits (196), Expect = 3e-15, Method: Composition-based stats. Identities = 42/300 (14%), Positives = 90/300 (30%), Gaps = 57/300 (19%) Query: 336 WKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQ-------- 387 WK S+ G + + P K +F + + T G + E Sbjct: 8 WKIIESYEGNSYTFIDPTQLPYNEKWEFPRN-NLQFGKTLGAGAFGKVVEATAFGLGKED 66 Query: 388 ---EVAVKTFCEGSPRAQRE-----VSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQ 439 +VAVK + ++E + + ++ ++V G+ +H G + V C Sbjct: 67 AVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCY 126 Query: 440 TLEACLDVHRGEDVENEED------EFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILI 493 + E ++ED + S + + + L S H+D+ +N+L+ Sbjct: 127 GDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFL-ASKNCIHRDVAARNVLL 185 Query: 494 DSKKAAHLADFDKSIKWAGDPQE------------------------VKRDLEDLGRLVL 529 + A + DF + D V+ D+ G L+ Sbjct: 186 TNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLW 245 Query: 530 YVVKKGSISFEDLKAQSNEEVVQLSPDEETK---------DLIHRLFHPGEHVRDCLSDL 580 + G + + S + + + ++ + R + Sbjct: 246 EIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 305 >4Y83-A nrPDB Length = 332 Score = 80.1 bits (196), Expect = 3e-15, Method: Composition-based stats. Identities = 53/285 (18%), Positives = 95/285 (33%), Gaps = 52/285 (18%) Query: 338 PQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLG--FYEKQEVAVKTFC 395 PQ+ + L + KL + I + G +YL K+ +A K Sbjct: 53 PQNGRYQIDSDVLLIPW-----KLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIP 107 Query: 396 EGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVEN 455 +V R + ++ YG+ + + + E + + E Sbjct: 108 VD-QFKPSDVEIQACFR-HENIAELYGAVLWGETVHLFME----AGEGGSVLEKLESCGP 161 Query: 456 EEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD-- 513 + V + K + LH S H D++P NI+ S KA L DF S++ D Sbjct: 162 MREFEIIWVTKHVLKGLDFLH-SKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVY 219 Query: 514 -------------PQEV-------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVV-- 551 P+ + K D+ LG +++ ++ G+ + +S Sbjct: 220 FPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIH-MQTGTPPWVKRYPRSAYPSYLY 278 Query: 552 ----QLSPDEET--------KDLIHRLFHPGEHVRDCLSDLLGHP 584 Q P E+ ++LI + R +DLL H Sbjct: 279 IIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHE 323 >5U6B-A nrPDB Length = 307 Score = 79.7 bits (195), Expect = 4e-15, Method: Composition-based stats. Identities = 42/281 (14%), Positives = 84/281 (29%), Gaps = 60/281 (21%) Query: 360 KLKFFIDEKYKI--ADTSEGGIYLGFYEKQ--------EVAVKTF------CEGSPRAQR 403 KL+ + +++K+ T G + E Q +VAVKT Sbjct: 14 KLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLS 73 Query: 404 EVSCLQSSRENSHLVTFYGSESHRGHL------FVCVTLC-EQTLEACLDVHRG--EDVE 454 E C++ ++ +++ G V + L + L R + V Sbjct: 74 EAVCMKEF-DHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVY 132 Query: 455 NEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDP 514 + ++ I ++ L + + H+DL +N +++ + +ADF S K Sbjct: 133 LPTQMLVK-FMADIASGMEYL-STKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGD 190 Query: 515 QEV------------------------KRDLEDLGRLVLYVVKKGSISF--------EDL 542 K D+ G + + +G + D Sbjct: 191 YYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDY 250 Query: 543 KAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGH 583 Q N + L+ R + R ++L Sbjct: 251 LRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELRED 291 >5XVU-A nrPDB Length = 332 Score = 79.7 bits (195), Expect = 4e-15, Method: Composition-based stats. Identities = 46/303 (15%), Positives = 89/303 (29%), Gaps = 84/303 (27%) Query: 360 KLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFC-------EGSPRAQREVSCLQSSR 412 +L++ +Y+I G Y + + C + +RE+ LQ+ Sbjct: 24 ELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKVLKPVKKKKIKREIKILQNLN 83 Query: 413 ENSHLVTFYGSESH--RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFK 470 +++ + + D+ R + I K Sbjct: 84 GGPNIIKLLDIVKDPVTKTPSLIFEYINN-------IDFKTLYPKFTDKDIRYYIYQILK 136 Query: 471 AVQELHLSCGYTHQDLQPQNILID-SKKAAHLADFDK--------------SIKWAGDP- 514 A+ H S G H+D++P NI+ID + L + + ++ P Sbjct: 137 ALDYCH-SQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRYYKGPE 195 Query: 515 -------QEVKRDLEDLGRLVLYVVKKGSISF------------------EDLKAQSNEE 549 + D+ LG ++ ++ K F EDL A + Sbjct: 196 LLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKY 255 Query: 550 VVQLSPD--------------------------EETKDLIHRLFHPGEHVRDCLSDLLGH 583 ++L P +E DLI ++ R + + H Sbjct: 256 NIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEH 315 Query: 584 PFF 586 P+F Sbjct: 316 PYF 318 >4NEU-A nrPDB Length = 333 Score = 79.7 bits (195), Expect = 4e-15, Method: Composition-based stats. Identities = 49/305 (16%), Positives = 98/305 (32%), Gaps = 69/305 (22%) Query: 367 EKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSP------RAQREVSCLQSSRENSHLVTF 420 E ++ G + L F+ Q + + P A E + + + +S +V Sbjct: 28 ESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKL 87 Query: 421 YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG 480 G G + + E + L ++ R +L I + + LH G Sbjct: 88 LGVIIEEGKYSLVMEYME---KGNLMHVLKAEMSTPLSVKGRIIL-EIIEGMCYLHGK-G 142 Query: 481 YTHQDLQPQNILIDSKKAAHLADFDKS-----------------------IKWAGDPQEV 517 H+DL+P+NIL+D+ +AD + K G + Sbjct: 143 VIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYM 202 Query: 518 --------------KRDLEDLGRLVLYVVKKGSISFED----------LKAQSNEEVVQL 553 K D+ +VL+ + +E+ +K+ + +V + Sbjct: 203 APEHLNDVNAKPTEKSDVYSF-AVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDI 261 Query: 554 SPD--EETKDLIHRLFHPGEHVRDCLSDLLG--HPFFWTW-----ESRYRTLRN-VGNES 603 + E L+ + R + PF+ + E ++L+ NE+ Sbjct: 262 TEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNEN 321 Query: 604 DIKTR 608 + R Sbjct: 322 AVVKR 326 >3AOX-A nrPDB Length = 344 Score = 79.7 bits (195), Expect = 4e-15, Method: Composition-based stats. Identities = 43/283 (15%), Positives = 80/283 (28%), Gaps = 64/283 (22%) Query: 358 IGKLKFFIDEKYKIADTSEGGIYLGFYEKQ-----------EVAVKTFCEGSPRAQREVS 406 I LK + + G + YE Q +VAVKT E E+ Sbjct: 38 ISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQD-ELD 96 Query: 407 CLQSSR-----ENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFA 461 L + + ++V G F+ + L + ++ A Sbjct: 97 FLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSF-LRETRPRPSQPSSLA 155 Query: 462 R----NVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA---AHLADFDKSIKWAGDP 514 +V I Q L + + H+D+ +N L+ A + DF + Sbjct: 156 MLDLLHVARDIACGCQYLEENH-FIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRAS 214 Query: 515 QEVK------------------------RDLEDLGRLVLYVVKKGSISFEDLKAQSNEEV 550 K D G L+ + G + + +SN+EV Sbjct: 215 YYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS---KSNQEV 271 Query: 551 VQLSPDEETKD-----------LIHRLFHPGEHVRDCLSDLLG 582 ++ D ++ + + R + +L Sbjct: 272 LEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE 314 >5LPV-A nrPDB Length = 296 Score = 79.7 bits (195), Expect = 4e-15, Method: Composition-based stats. Identities = 40/249 (16%), Positives = 72/249 (28%), Gaps = 37/249 (14%) Query: 368 KYKIADTSEGGIYLGFYEK-QEVAVKTFCEGSPRAQREVSCLQSSRE---NSHLVTFYGS 423 I G +Y + VA+K S + RE + + +LV G Sbjct: 22 DSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGY 81 Query: 424 ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG--Y 481 + + + + R + + + LH +C Sbjct: 82 CKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHI 141 Query: 482 THQDLQPQNILIDSKKAAHLADFDKSI------------KWAGDPQEV------------ 517 H+D++ N+L+D A ++DF + AG P V Sbjct: 142 IHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCST 201 Query: 518 KRDLEDLGRLVLYVVKKGSISFEDLKAQSN--EEVVQLSPDEETKDLIH-RLFHPGEHVR 574 K D+ G ++L + G + N V+ D+ L + Sbjct: 202 KGDVYSYGVVLL-ELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELMKEDPALE 260 Query: 575 DCLSDLLGH 583 +LL H Sbjct: 261 I---ELLQH 266 >4LQP-A nrPDB Length = 508 Score = 79.7 bits (195), Expect = 5e-15, Method: Composition-based stats. Identities = 31/154 (20%), Positives = 62/154 (40%), Gaps = 10/154 (6%) Query: 357 MIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSH 416 +IGK F E + G IY + K +A+R+V ++ Sbjct: 109 VIGKGAF--GEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLA---GSDSPW 163 Query: 417 LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 +V+ Y S +L++ + + + + ++ R ++ A++ +H Sbjct: 164 VVSLYYSFQDAQYLYLIMEFLPGGDLMTMLI----RWQLFTEDVTRFYMAECILAIETIH 219 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKW 510 G+ H+ ++P NILID + L+DF S + Sbjct: 220 -KLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGF 252 Score = 46.2 bits (108), Expect = 5e-05, Method: Composition-based stats. Identities = 19/107 (17%), Positives = 30/107 (28%), Gaps = 27/107 (25%) Query: 506 KSIKWAGDPQEV------------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQ- 552 + G P + + D LG ++ Y G F Q + Sbjct: 319 MAYSTVGTPDYIAPEIFLYQGYGQECDWWSLGAIM-YECLIGWPPFCSETPQETYRKIMN 377 Query: 553 ----------LSPDEETKDLIHRLFHPGEHVRDC---LSDLLGHPFF 586 + E +DLI RL + ++ HPFF Sbjct: 378 FEQTLQFPDDIHISYEAEDLIRRLLTHADQRLGRHGGADEIKSHPFF 424 >3ZZW-A nrPDB Length = 289 Score = 79.4 bits (194), Expect = 5e-15, Method: Composition-based stats. Identities = 38/266 (14%), Positives = 85/266 (31%), Gaps = 56/266 (21%) Query: 370 KIADTSEGGIYLGFY-------EKQEVAVKTFCEGSPRAQREV----SCLQSSRENSHLV 418 ++ + G +Y G + Q VA+KT + + RE + L++ ++ ++V Sbjct: 16 ELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVV 75 Query: 419 TFYGSESHRGHLFVCVTLC-EQTLEACLDVHRGEDVENEEDEF-----------ARNVLS 466 G + L + + C L L + D+ ++++ Sbjct: 76 CLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVA 135 Query: 467 SIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE---------- 516 I ++ L S H+DL +N+L+ K ++D + Sbjct: 136 QIAAGMEYL-SSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPI 194 Query: 517 --------------VKRDLEDLGRLVLYVVKKGSISF------EDLKAQSNEEVVQLSPD 556 + D+ G ++ V G + + ++ N +V+ D Sbjct: 195 RWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDD 254 Query: 557 EET--KDLIHRLFHPGEHVRDCLSDL 580 L+ ++ R D+ Sbjct: 255 CPAWVYALMIECWNEFPSRRPRFKDI 280 >4FL3-A nrPDB Length = 635 Score = 79.4 bits (194), Expect = 6e-15, Method: Composition-based stats. Identities = 36/261 (13%), Positives = 83/261 (31%), Gaps = 48/261 (18%) Query: 362 KFFIDEKYKIADTSEGGIYLGFYE------KQEVAVKTFCEGSPRAQREVSC---LQSSR 412 K E ++ + G + G+Y+ V + P + E+ + Sbjct: 368 KLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL 427 Query: 413 ENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAV 472 +N ++V G + + + + E L+ + ++ ++ ++ + + Sbjct: 428 DNPYIVRMIGICEAESWM-LVMEMAELGP---LNKYLQQNRHVKDKNI-IELVHQVSMGM 482 Query: 473 QELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV--------------- 517 + L S + H+DL +N+L+ ++ A ++DF S D Sbjct: 483 KYLEES-NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541 Query: 518 ----------KRDLEDLGRLVLYVVKKGSISFEDLKAQ------SNEEVVQLSPD--EET 559 K D+ G L+ G + +K E + E Sbjct: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM 601 Query: 560 KDLIHRLFHPGEHVRDCLSDL 580 DL++ + R + + Sbjct: 602 YDLMNLCWTYDVENRPGFAAV 622 >3QD2-B nrPDB Length = 332 Score = 79.0 bits (193), Expect = 7e-15, Method: Composition-based stats. Identities = 33/201 (16%), Positives = 69/201 (34%), Gaps = 41/201 (20%) Query: 425 SHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQ 484 S + +L++ + LC + R +E+ E ++ I +AV+ LH S G H+ Sbjct: 131 SPKVYLYIQMQLCRKENLKDWMNRRC-SLEDREHGVCLHIFIQIAEAVEFLH-SKGLMHR 188 Query: 485 DLQPQNILIDSKKAAHLADFDKSI----------------------------------KW 510 DL+P NI + DF + Sbjct: 189 DLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQI 248 Query: 511 AGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSP-----DEETKDLIHR 565 G+ K D+ LG ++ ++ S E ++ ++ ++ + ++ Sbjct: 249 HGNNYSHKVDIFSLGLILFELLYSFSTQMERVRIITDVRNLKFPLLFTQKYPQEHMMVQD 308 Query: 566 LFHPGEHVRDCLSDLLGHPFF 586 + P R +D++ + F Sbjct: 309 MLSPSPTERPEATDIIENAIF 329 >2QKW-B nrPDB Length = 321 Score = 79.0 bits (193), Expect = 7e-15, Method: Composition-based stats. Identities = 40/245 (16%), Positives = 74/245 (30%), Gaps = 30/245 (12%) Query: 366 DEKYKIADTSEGGIYLGFYEK-QEVAVKTFCEGSPRAQREVSCLQSSRE---NSHLVTFY 421 D K+ I G +Y G +VA+K S + E + + HLV+ Sbjct: 42 DHKFLIGHGVFGKVYKGVLRDGAKVALKRRTPESSQGIEEFETEIETLSFCRHPHLVSLI 101 Query: 422 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 G R + + E + E + + + LH + Sbjct: 102 GFCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLH-TRAI 160 Query: 482 THQDLQPQNILIDSKKAAHLADFDKSIKWAG-----------------DPQEV------- 517 H+D++ NIL+D + DF S K DP+ Sbjct: 161 IHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRLTE 220 Query: 518 KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCL 577 K D+ G +VL+ V + + + + + + + ++ P + Sbjct: 221 KSDVYSFG-VVLFEVLCARSAIVQSLPREMVNLAEWAVESHNNGQLEQIVDPNLADKIRP 279 Query: 578 SDLLG 582 L Sbjct: 280 ESLRK 284 >5WNO-A nrPDB Length = 330 Score = 78.6 bits (192), Expect = 1e-14, Method: Composition-based stats. Identities = 40/253 (15%), Positives = 74/253 (29%), Gaps = 53/253 (20%) Query: 368 KYKIADTSEGGIYLGFYEKQ-------EVAVKTFCEGSPRAQR---EVSCLQSSRENSHL 417 K+ + G ++ G Y + VA+K F + E + + R + +L Sbjct: 27 DKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLR-HDNL 85 Query: 418 VTFYGSESHRGHLFVCVTLCE-QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 + G H L + L+ L +H+ E++ E I +Q L Sbjct: 86 LKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHK-ENLGAREQVL---YCYQIASGMQYL- 140 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV------------------- 517 H+DL +N+L+ + DF S D + Sbjct: 141 EKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSK 200 Query: 518 -----KRDLEDLGRLVLYVVKKGSISFEDLKAQS----------NEEVVQLSPDEETKDL 562 D+ G ++ G ++ + S + S D + L Sbjct: 201 HCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELL 260 Query: 563 IHRLFHPGEHVRD 575 R + R Sbjct: 261 --RCWMADPKSRP 271 >3PLS-A nrPDB Length = 298 Score = 78.2 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 40/279 (14%), Positives = 82/279 (29%), Gaps = 52/279 (18%) Query: 350 LHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQ-----EVAVKTFCEGSPRAQRE 404 L + +I + I G +Y G Y Q + A+K+ + Q E Sbjct: 8 LAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVE 67 Query: 405 V----SCLQSSRENSHLVTFYG-SESHRGHLFVCV-TLCEQTLEACLDVHRGEDVENEED 458 L + +++ G G V + +C L + + +D Sbjct: 68 AFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQF--IRSPQRNPTVKD 125 Query: 459 EFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE-- 516 + + + ++ L + H+DL +N ++D +ADF + Sbjct: 126 LI--SFGLQVARGMEYL-AEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSV 182 Query: 517 ------------------------VKRDLEDLGRLVLYVVKKGSISFED---------LK 543 K D+ G L+ ++ +G+ + L Sbjct: 183 QQHRHARLPVKWTALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLA 242 Query: 544 AQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLG 582 + PD ++ + + VR L+G Sbjct: 243 QGRRLPQPEYCPDS-LYQVMQQCWEADPAVRPTFRVLVG 280 >5UIL-A nrPDB Length = 405 Score = 78.2 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 36/116 (31%), Positives = 57/116 (49%), Gaps = 9/116 (7%) Query: 65 NAVQMSREDIVELLLRHGADPVLRKKN--GATPFILAAIAGSVKLLKLFLSKGADVNECD 122 A + S + L+R A +L +KN G +P I+AA G+++L+K +SKGA++N+ + Sbjct: 284 EACKYSDSKYIAKLIR--AKSILFEKNIYGWSPVIVAAYHGNIELIKWLVSKGANINDRN 341 Query: 123 FYGFTAFMEAAVY----GKVKALKFLYKRGANVNLRR-KTKEDQERLRKGGATALM 173 + G T M Y G LK L G ++ L K + L K G L+ Sbjct: 342 YKGTTVAMYFKDYMLKSGDYSGLKMLIDLGLDLTLTDYKDYTVFDYLEKSGNKNLL 397 Score = 55.1 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 25/130 (19%), Positives = 55/130 (42%), Gaps = 11/130 (8%) Query: 23 VEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHG 82 ++ +++A + D + +L+ ++ F++ GW+P+ A ++++ L+ G Sbjct: 276 KDNFKEILEACKYSDSKYIAKLIRAK-SILFEKNIYGWSPVIVAAYHGNIELIKWLVSKG 334 Query: 83 ADPVLRKKNGATPFILAAIA-------GSVKLLKLFLSKGADVNECDFYGFTAFMEAAVY 135 A+ R G T +A G LK+ + G D+ D+ +T F Sbjct: 335 ANINDRNYKGTT---VAMYFKDYMLKSGDYSGLKMLIDLGLDLTLTDYKDYTVFDYLEKS 391 Query: 136 GKVKALKFLY 145 G L+++ Sbjct: 392 GNKNLLQYMM 401 Score = 43.2 bits (100), Expect = 4e-04, Method: Composition-based stats. Identities = 15/60 (25%), Positives = 31/60 (51%) Query: 96 FILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR 155 + A K + + + + E + YG++ + AA +G ++ +K+L +GAN+N R Sbjct: 282 ILEACKYSDSKYIAKLIRAKSILFEKNIYGWSPVIVAAYHGNIELIKWLVSKGANINDRN 341 Score = 35.4 bits (80), Expect = 0.080, Method: Composition-based stats. Identities = 10/70 (14%), Positives = 29/70 (41%), Gaps = 1/70 (1%) Query: 246 AVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLV 305 A + + +L+ + I + + + G + +++A ++ + L +GA+ + + Sbjct: 285 ACKYSDSKYIAKLIRAKSI-LFEKNIYGWSPVIVAAYHGNIELIKWLVSKGANINDRNYK 343 Query: 306 MTARRNYDHS 315 T Y Sbjct: 344 GTTVAMYFKD 353 >3DEO-A nrPDB Length = 183 Score = 78.2 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 36/133 (27%), Positives = 56/133 (42%), Gaps = 3/133 (2%) Query: 1 MESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGW 60 +E +D ++P P+S E A + D + QLLE +V+ + E G Sbjct: 20 IEWKDGHSPSWVPSSYIAADVVSEYETPWWTAARKADEQALSQLLED-RDVDAVD-ENGR 77 Query: 61 TPLHNAVQMSREDIVELLLRHGADPVLRK-KNGATPFILAAIAGSVKLLKLFLSKGADVN 119 T L + + V LL GAD R + G T +AA ++++ + GAD+ Sbjct: 78 TALLFVAGLGSDKCVRLLAEAGADLDHRDMRGGLTALHMAAGYVRPEVVEALVELGADIE 137 Query: 120 ECDFYGFTAFMEA 132 D G TA A Sbjct: 138 VEDERGLTALELA 150 Score = 77.4 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 32/135 (23%), Positives = 55/135 (40%), Gaps = 8/135 (5%) Query: 60 WTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVN 119 TP A + + E + LL D +NG T + A GS K ++L GAD++ Sbjct: 45 ETPWWTAARKADEQALSQLLED-RDVDAVDENGRTALLFVAGLGSDKCVRLLAEAGADLD 103 Query: 120 ECDFYG-FTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRK------GGATAL 172 D G TA AA Y + + ++ L + GA++ + + L + + Sbjct: 104 HRDMRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELAREILKTTPKGNPM 163 Query: 173 MDAAEKGHVEVLKIL 187 G +V+ +L Sbjct: 164 QFGRRIGLEKVINVL 178 Score = 62.8 bits (151), Expect = 5e-10, Method: Composition-based stats. Identities = 34/120 (28%), Positives = 52/120 (43%), Gaps = 15/120 (12%) Query: 127 TAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKI 186 T + AA +AL L + D + + + G TAL+ A G + ++ Sbjct: 46 TPWWTAARKADEQALSQLLE-----------DRDVDAVDENGRTALLFVAGLGSDKCVR- 93 Query: 187 LLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILA 246 LL E GAD++ D G +H + + L++ GAD+ V ERG T L LA Sbjct: 94 LLAEAGADLDHRDMRGGLTALH---MAAGYVRPEVVEALVELGADIEVEDERGLTALELA 150 Score = 61.6 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 27/108 (25%), Positives = 47/108 (43%), Gaps = 4/108 (3%) Query: 212 SSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTD- 270 ++ +D +A++ LL D DV+ E G+T L+ V RLL + +++ D Sbjct: 51 AARKADEQALSQLLEDR--DVDAVDENGRTALLFVAGLGSDKCV-RLLAEAGADLDHRDM 107 Query: 271 SDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVK 318 G TAL +A ++ E L + GA + D ++K Sbjct: 108 RGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELAREILK 155 Score = 45.5 bits (106), Expect = 1e-04, Method: Composition-based stats. Identities = 26/93 (27%), Positives = 39/93 (41%), Gaps = 8/93 (8%) Query: 240 KTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAST 299 +TP A K + +LLE +++ D +G+TALL L K LL + GA Sbjct: 45 ETPWWTAARKADEQALSQLLE--DRDVDAVDENGRTALLFVAGLGSDKCVRLLAEAGADL 102 Query: 300 DCGDLVMT------ARRNYDHSLVKVLLSHGAK 326 D D+ A +V+ L+ GA Sbjct: 103 DHRDMRGGLTALHMAAGYVRPEVVEALVELGAD 135 >5AN8-A nrPDB Length = 613 Score = 78.2 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 42/203 (20%), Positives = 81/203 (39%), Gaps = 31/203 (15%) Query: 91 NGATPFILAA---IAGSVKLLKLFLS-----------KGADVNECDFYGFTAFMEAAVYG 136 G T + A G ++ L A + + G +A A Sbjct: 39 TGKTCLMKAVLNLQDGVNACIQPLLEIDRDSGNPQPLVNAQCTDEYYRGHSALHIAIEKR 98 Query: 137 KVKALKFLYKRGANVNLRR---KTKEDQERLRKGGATALMDAAEKGHVEVLKILLD--EM 191 ++ +K L + GANV+ + +++Q+ G L AA +V+ LL+ Sbjct: 99 SLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQWDVVNYLLENPHP 158 Query: 192 GADVNACDNMGRNALIHALLSSDD--SDVEAITHL---LLDHGA----DVNVR---GERG 239 A + A D++G L ++ +D+ + + + LL GA +V + G Sbjct: 159 AASLQAQDSLGNTVLHALVMIADNSPENSALVVRMYDGLLQAGARLCPNVQLEGIPNLEG 218 Query: 240 KTPLILAVEKKHLGLVQRLLEQE 262 TPL LA ++ + + + +L++E Sbjct: 219 LTPLKLAAKEGKIEIFKHILQRE 241 Score = 61.3 bits (147), Expect = 2e-09, Method: Composition-based stats. Identities = 49/216 (22%), Positives = 82/216 (37%), Gaps = 34/216 (15%) Query: 4 RDHNNPQEGPTSSSGRRAAVEDNH-LLIKAVQNEDVDLVQQLLEGGANVN-------FQE 55 RD NPQ P ++ H L A++ + V+ L+E GANV+ FQ+ Sbjct: 67 RDSGNPQ--PLVNAQCTDEYYRGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQK 124 Query: 56 EEG-----GWTPLHNAVQMSREDIVELLLRH---GADPVLRKKNGATPFI----LA--AI 101 + G PL A + D+V LL + A + G T +A + Sbjct: 125 NQDTCFYFGELPLSLAACTKQWDVVNYLLENPHPAASLQAQDSLGNTVLHALVMIADNSP 184 Query: 102 AGSVKLLKL---FLSKGADV--NEC-----DFYGFTAFMEAAVYGKVKALKFLYKRGANV 151 S ++++ L GA + N + G T AA GK++ K + +R + Sbjct: 185 ENSALVVRMYDGLLQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQREFSA 244 Query: 152 NLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKIL 187 + +++ E +L D A E +L Sbjct: 245 PCQSLSRKFTEWCYGPVRVSLYDLASVDSWEENSVL 280 Score = 60.9 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 43/202 (21%), Positives = 71/202 (35%), Gaps = 41/202 (20%) Query: 27 HLLIKAVQNEDVDL---VQQLLEGGAN-------VNFQEEEG---GWTPLHNAVQMSRED 73 L+KAV N + +Q LLE + VN Q + G + LH A++ Sbjct: 42 TCLMKAVLNLQDGVNACIQPLLEIDRDSGNPQPLVNAQCTDEYYRGHSALHIAIEKRSLQ 101 Query: 74 IVELLLRHGADPVLRKKN-------------GATPFILAAIAGSVKLLKLFLSKG---AD 117 V+LL+ +GA+ + G P LAA ++ L A Sbjct: 102 CVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQWDVVNYLLENPHPAAS 161 Query: 118 VNECDFYGFTAFMEAAV------YGKVKALKF---LYKRGANVNLRRKTKEDQERLRKGG 168 + D G T + ++ L + GA + + + G Sbjct: 162 LQAQDSLGNTVLHALVMIADNSPENSALVVRMYDGLLQAGARLCPNVQLEGIP---NLEG 218 Query: 169 ATALMDAAEKGHVEVLKILLDE 190 T L AA++G +E+ K +L Sbjct: 219 LTPLKLAAKEGKIEIFKHILQR 240 Score = 38.5 bits (88), Expect = 0.010, Method: Composition-based stats. Identities = 22/83 (26%), Positives = 36/83 (43%), Gaps = 13/83 (15%) Query: 233 NVRGERGKTPLILAV---EKKHLGLVQRLLEQEHIE------INDTDSD----GKTALLL 279 G GKT L+ AV + +Q LLE + +N +D G +AL + Sbjct: 34 YTEGSTGKTCLMKAVLNLQDGVNACIQPLLEIDRDSGNPQPLVNAQCTDEYYRGHSALHI 93 Query: 280 AVELKLKKIAELLCKRGASTDCG 302 A+E + + +LL + GA+ Sbjct: 94 AIEKRSLQCVKLLVENGANVHAK 116 >3UI2-A nrPDB Length = 244 Score = 78.2 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 36/133 (27%), Positives = 56/133 (42%), Gaps = 3/133 (2%) Query: 1 MESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGW 60 +E +D ++P P+S E A + D + QLLE +V+ + E G Sbjct: 21 IEWKDGHSPSWVPSSYIAADVVSEYETPWWTAARKADEQALSQLLED-RDVDAVD-ENGR 78 Query: 61 TPLHNAVQMSREDIVELLLRHGADPVLRK-KNGATPFILAAIAGSVKLLKLFLSKGADVN 119 T L + + V LL GAD R + G T +AA ++++ + GAD+ Sbjct: 79 TALLFVAGLGSDKCVRLLAEAGADLDHRDMRGGLTALHMAAGYVRPEVVEALVELGADIE 138 Query: 120 ECDFYGFTAFMEA 132 D G TA A Sbjct: 139 VEDERGLTALELA 151 Score = 77.0 bits (188), Expect = 3e-14, Method: Composition-based stats. Identities = 32/135 (23%), Positives = 55/135 (40%), Gaps = 8/135 (5%) Query: 60 WTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVN 119 TP A + + E + LL D +NG T + A GS K ++L GAD++ Sbjct: 46 ETPWWTAARKADEQALSQLLED-RDVDAVDENGRTALLFVAGLGSDKCVRLLAEAGADLD 104 Query: 120 ECDFYG-FTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRK------GGATAL 172 D G TA AA Y + + ++ L + GA++ + + L + + Sbjct: 105 HRDMRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELAREILKTTPKGNPM 164 Query: 173 MDAAEKGHVEVLKIL 187 G +V+ +L Sbjct: 165 QFGRRIGLEKVINVL 179 Score = 62.8 bits (151), Expect = 5e-10, Method: Composition-based stats. Identities = 34/120 (28%), Positives = 52/120 (43%), Gaps = 15/120 (12%) Query: 127 TAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKI 186 T + AA +AL L + D + + + G TAL+ A G + ++ Sbjct: 47 TPWWTAARKADEQALSQLLE-----------DRDVDAVDENGRTALLFVAGLGSDKCVR- 94 Query: 187 LLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILA 246 LL E GAD++ D G +H + + L++ GAD+ V ERG T L LA Sbjct: 95 LLAEAGADLDHRDMRGGLTALH---MAAGYVRPEVVEALVELGADIEVEDERGLTALELA 151 Score = 62.4 bits (150), Expect = 6e-10, Method: Composition-based stats. Identities = 42/196 (21%), Positives = 73/196 (37%), Gaps = 10/196 (5%) Query: 212 SSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTD- 270 ++ +D +A++ LL D DV+ E G+T L+ V RLL + +++ D Sbjct: 52 AARKADEQALSQLLEDR--DVDAVDENGRTALLFVAGLGSDKCV-RLLAEAGADLDHRDM 108 Query: 271 SDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFH 330 G TAL +A ++ E L + GA + D ++K G F Sbjct: 109 RGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELAREILKTTPK-GNPMQFG 167 Query: 331 PPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEG--GIYLGFYEKQE 388 K + G + ++ K D +Y + G G + ++ Sbjct: 168 RRIGLEKVINVLEGQVFEYAE--VDEIVEKRGKGKDVEYLVRWKDGGDCEWVKGVHVAED 225 Query: 389 VAVKTFCEGSPRAQRE 404 VA K + +G A E Sbjct: 226 VA-KDYEDGLEYAVAE 240 >2BUJ-A nrPDB Length = 317 Score = 77.8 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 42/277 (15%), Positives = 88/277 (31%), Gaps = 55/277 (19%) Query: 357 MIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFC----EGSPRAQREVSCLQSSR 412 +I + +K S + G ++ A+K + AQRE + Sbjct: 25 IIDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREAD-MHRLF 83 Query: 413 ENSHLVTF--YGSESH--RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 + +++ Y + ++ + ++ + ++ +L I Sbjct: 84 NHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGI 143 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDK----SIKWAGDPQEV------- 517 + ++ +H GY H+DL+P NIL+ + L D I G Q + Sbjct: 144 CRGLEAIHAK-GYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAA 202 Query: 518 -----------------------KRDLEDLGRLVLYVVKKGSISFEDLKAQ--------S 546 + D+ LG + LY + G ++ + + Sbjct: 203 QRCTISYRAPELFSVQSHCVIDERTDVWSLGCV-LYAMMFGEGPYDMVFQKGDSVALAVQ 261 Query: 547 NEEVVQLSP--DEETKDLIHRLFHPGEHVRDCLSDLL 581 N+ + SP L++ + H R + LL Sbjct: 262 NQLSIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLL 298 >3BEA-A nrPDB Length = 333 Score = 77.8 bits (190), Expect = 2e-14, Method: Composition-based stats. Identities = 43/306 (14%), Positives = 90/306 (29%), Gaps = 65/306 (21%) Query: 336 WKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQ-------- 387 WK S+ G + + P K +F + + T G + E Sbjct: 16 WKIIESYEGNSYTFIDPTQLPYNEKWEFPRN-NLQFGKTLGAGAFGKVVEATAFGLGKED 74 Query: 388 ---EVAVKTFCEGSPRAQRE-----VSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQ 439 +VAVK + ++E + + ++ ++V G+ +H G + V C Sbjct: 75 AVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYC-- 132 Query: 440 TLEACLDVHRGEDVENEEDEFAR------------NVLSSIFKAVQELHLSCGYTHQDLQ 487 L+ R + E D + S + + + L S H+D+ Sbjct: 133 CYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFL-ASKNCIHRDVA 191 Query: 488 PQNILIDSKKAAHLADFDKSIKWAGDPQE------------------------VKRDLED 523 +N+L+ + A + DF + D V+ D+ Sbjct: 192 ARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWS 251 Query: 524 LGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETK---------DLIHRLFHPGEHVR 574 G L+ + G + + S + + + ++ + R Sbjct: 252 YGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR 311 Query: 575 DCLSDL 580 + Sbjct: 312 PTFQQI 317 >4MD7-E nrPDB Length = 391 Score = 77.4 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 44/298 (14%), Positives = 89/298 (29%), Gaps = 84/298 (28%) Query: 367 EKYKIADTSEGGIYLGFYEKQEVA-------VKTFCEGSPRAQREVSCLQSSRENSHLVT 419 + Y++ G Y +E + + +RE+ L++ R +++T Sbjct: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIIT 96 Query: 420 FYGSESH--RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL 477 + T + + D R + I KA+ H Sbjct: 97 LADIVKDPVSRTPALVFEHVNNT-------DFKQLYQTLTDYDIRFYMYEILKALDYCH- 148 Query: 478 SCGYTHQDLQPQNILID-SKKAAHLADFDK--------------SIKWAGDP-------- 514 S G H+D++P N++ID + L D+ + ++ P Sbjct: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 Query: 515 QEVKRDLEDLGRLVLYVVKKGSISF------------------EDLKAQSNEEVVQLSP- 555 + D+ LG ++ ++ + F EDL ++ ++L P Sbjct: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 Query: 556 -------------------------DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWT 588 E D + +L R + + HP+F+T Sbjct: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 >4IDT-A nrPDB Length = 356 Score = 77.4 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 42/250 (16%), Positives = 79/250 (31%), Gaps = 52/250 (20%) Query: 375 SEGGIYLGFYEKQEV------AVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRG 428 G + + ++ AVK RA+ ++C + + +V YG+ Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMAC--AGLTSPRIVPLYGAVREGP 139 Query: 429 HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQP 488 + + + L E L ++ ++ A L + ++ LH S H D++ Sbjct: 140 WVNIFMELLEGGSLGQL----VKEQGCLPEDRALYYLGQALEGLEYLH-SRRILHGDVKA 194 Query: 489 QNILIDSKK-AAHLADFDKSIKWAGD--------------------PQEV-------KRD 520 N+L+ S A L DF ++ D P+ V K D Sbjct: 195 DNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAKVD 254 Query: 521 LEDLGRLVLYVVKKGSISFED-------LKAQSNEEVV-QLSPD--EETKDLIHRLFHPG 570 + ++ + G + LK S V ++ P T I Sbjct: 255 VWS-SCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKE 313 Query: 571 EHVRDCLSDL 580 R ++L Sbjct: 314 PIHRVSAAEL 323 >3VHK-A nrPDB Length = 368 Score = 77.4 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 29/150 (19%), Positives = 51/150 (34%), Gaps = 34/150 (22%) Query: 467 SIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVK-------- 518 + K ++ L S H+DL +NIL+ K + DF + DP V+ Sbjct: 208 QVAKGMEFL-ASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPL 266 Query: 519 ----------------RDLEDLGRLVLYVVKKGSISF------EDLKAQSNEEVVQLSPD 556 D+ G L+ + G+ + E+ + E +PD Sbjct: 267 KWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPD 326 Query: 557 EETKDLIHRLF---HPGEHVRDCLSDLLGH 583 T ++ + H R S+L+ H Sbjct: 327 YTTPEMYQTMLDCWHGEPSQRPTFSELVEH 356 >2PVN-A nrPDB Length = 352 Score = 77.4 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 46/296 (15%), Positives = 85/296 (28%), Gaps = 84/296 (28%) Query: 367 EKYKIADTSEGGIYLGFYEKQEV-------AVKTFCEGSPRAQREVSCLQSSRENSHLVT 419 + Y++ G Y +E V + +RE+ LQ+ ++V Sbjct: 52 DDYEVVRKVGRGKYSEVFEGINVNNNEKCIIKILKPVKKKKIKREIKILQNLCGGPNIVK 111 Query: 420 FYGS--ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL 477 + H + T L D R + + KA+ H Sbjct: 112 LLDIVRDQHSKTPSLIFEYVNNTDFKVL-------YPTLTDYDIRYYIYELLKALDYCH- 163 Query: 478 SCGYTHQDLQPQNILID-SKKAAHLADFDKSI--------------------KWAGDPQ- 515 S G H+D++P N++ID + L D+ + + D Q Sbjct: 164 SQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQD 223 Query: 516 -EVKRDLEDLGRLVLYVVKKGSISF------------------EDLKAQSNEEVVQLSP- 555 + D+ LG + ++ + F + L A N+ ++L P Sbjct: 224 YDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELDPQ 283 Query: 556 -------------------------DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 E D + +L R + + HP+F Sbjct: 284 LEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYF 339 >4LFI-A nrPDB Length = 374 Score = 77.4 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 36/251 (14%), Positives = 71/251 (28%), Gaps = 77/251 (30%) Query: 413 ENSHLVTFYGSESH--RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFK 470 +++++ + + + +D D R + + K Sbjct: 131 GHANIIHLFDIIKDPISKTPALVFEYVDN-----VDFRILYPKLT--DLEIRFYMFELLK 183 Query: 471 AVQELHLSCGYTHQDLQPQNILID-SKKAAHLADFDK--------------SIKWAGDP- 514 A+ H S G H+D++P N++ID K L D+ + ++ P Sbjct: 184 ALDYCH-SMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPE 242 Query: 515 -------QEVKRDLEDLGRLVLYVVKKGSI------------------------------ 537 + DL G ++ ++ K Sbjct: 243 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 302 Query: 538 ------SFEDLKAQSNEEVVQ--------LSPDEETKDLIHRLFHPGEHVRDCLSDLLGH 583 F D+ + + LS ++E DLI L R + +GH Sbjct: 303 EITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGH 362 Query: 584 PFFWTWESRYR 594 P+F + Sbjct: 363 PWFAPIREQIE 373 >6HMD-A nrPDB Length = 365 Score = 77.0 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 46/298 (15%), Positives = 87/298 (29%), Gaps = 84/298 (28%) Query: 367 EKYKIADTSEGGIYLGFYEK-------QEVAVKTFCEGSPRAQREVSCLQSSRENSHLVT 419 + Y++ G Y +E + V + +REV L++ R ++++ Sbjct: 53 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIK 112 Query: 420 FYGSESH--RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL 477 + + T L D R + + KA+ H Sbjct: 113 LIDTVKDPVSKTPALVFEYINNTDFKQLYQIL-------TDFDIRFYMYELLKALDYCH- 164 Query: 478 SCGYTHQDLQPQNILID-SKKAAHLADFDK--------------SIKWAGDP-------- 514 S G H+D++P N++ID +K L D+ + ++ P Sbjct: 165 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 224 Query: 515 QEVKRDLEDLGRLV-------------------------------LYVVKKGS-----IS 538 + D+ LG ++ LY K Sbjct: 225 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 284 Query: 539 FEDL----KAQSNEEVVQLSP----DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWT 588 F D+ + E + E DL+ +L R + + HP+F+ Sbjct: 285 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 342 >2A5E-A nrPDB Length = 156 Score = 77.0 bits (188), Expect = 3e-14, Method: Composition-based stats. Identities = 35/131 (26%), Positives = 52/131 (39%), Gaps = 4/131 (3%) Query: 15 SSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDI 74 ++G + L A + V+ V+ LLE GA N G P+ + M + Sbjct: 3 PAAGSSMEPSADWLATAAAR-GRVEEVRALLEAGALPNAPNSYGRR-PIQV-MMMGSARV 59 Query: 75 VELLLRHGADPVLRKKNGAT-PFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAA 133 ELLL HGA+P T P AA G + L + GA ++ D +G A Sbjct: 60 AELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAE 119 Query: 134 VYGKVKALKFL 144 G ++L Sbjct: 120 ELGHRDVARYL 130 Score = 70.1 bits (170), Expect = 3e-12, Method: Composition-based stats. Identities = 36/128 (28%), Positives = 52/128 (40%), Gaps = 12/128 (9%) Query: 66 AVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYG 125 A R + V LL GA P G P I + GS ++ +L L GA+ N D Sbjct: 19 AAARGRVEEVRALLEAGALPNAPNSYGRRP-IQVMMMGSARVAELLLLHGAEPNCADPAT 77 Query: 126 FT-AFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVL 184 T +AA G + L L++ GA +++R G + A E GH +V Sbjct: 78 LTRPVHDAAREGFLDTLVVLHRAGARLDVRD----------AWGRLPVDLAEELGHRDVA 127 Query: 185 KILLDEMG 192 + L G Sbjct: 128 RYLRAAAG 135 Score = 69.0 bits (167), Expect = 7e-12, Method: Composition-based stats. Identities = 37/129 (28%), Positives = 58/129 (44%), Gaps = 8/129 (6%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 L AA +G VE ++ LL E GA NA ++ GR + ++ S + LLL HGA+ Sbjct: 16 LATAAARGRVEEVRALL-EAGALPNAPNSYGRRPIQVMMMGSAR-----VAELLLLHGAE 69 Query: 232 VNVRGERGKT-PLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAE 290 N T P+ A + L + L + ++ D+ G+ + LA EL + +A Sbjct: 70 PNCADPATLTRPVHDAAREGFLDTLVVL-HRAGARLDVRDAWGRLPVDLAEELGHRDVAR 128 Query: 291 LLCKRGAST 299 L T Sbjct: 129 YLRAAAGGT 137 Score = 57.4 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 29/127 (22%), Positives = 47/127 (37%), Gaps = 15/127 (11%) Query: 132 AAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEM 191 AA G+V+ ++ L + GA N ++ G V ++LL Sbjct: 19 AAARGRVEEVRALLEAGALPNAPNSYGRRPIQVM-----------MMGSARVAELLLLH- 66 Query: 192 GADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKH 251 GA+ N D +H +L GA ++VR G+ P+ LA E H Sbjct: 67 GAEPNCADPATLTRPVHDAA---REGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGH 123 Query: 252 LGLVQRL 258 + + L Sbjct: 124 RDVARYL 130 Score = 50.9 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 21/110 (19%), Positives = 34/110 (30%), Gaps = 3/110 (2%) Query: 209 ALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEIND 268 L ++ LL+ GA N G+ P+ + + + + LL E N Sbjct: 15 WLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQV-MMMGSARVAELLLL-HGAEPNC 72 Query: 269 TDSDGKT-ALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLV 317 D T + A +L + GA D D + L Sbjct: 73 ADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELG 122 >6DBN-A nrPDB Length = 316 Score = 76.7 bits (187), Expect = 3e-14, Method: Composition-based stats. Identities = 36/273 (13%), Positives = 85/273 (31%), Gaps = 67/273 (24%) Query: 371 IADTSEGGIYLGFYEKQE------VAVKTFCEGS-----PRAQREVSCLQSSRENSHLVT 419 + + G + L Y+ + VAVK+ S ++E+ L++ + ++V Sbjct: 43 LGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLY-HENIVK 101 Query: 420 F--YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL 477 + +E + + + L + ++ + I K + L Sbjct: 102 YKGICTEDGGNGIKLIMEFLP---SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYL-G 157 Query: 478 SCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQ---------------------- 515 S Y H+DL +N+L++S+ + DF + D + Sbjct: 158 SRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQ 217 Query: 516 ---EVKRDLEDLGRLV---------------LYVVKKGSISFEDLKAQS------NEEVV 551 + D+ G + L++ G + + + + Sbjct: 218 SKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIG-PTHGQMTVTRLVNTLKEGKRL 276 Query: 552 QLSPD--EETKDLIHRLFHPGEHVRDCLSDLLG 582 P+ +E L+ + + R +L+ Sbjct: 277 PCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIE 309 >2F37-A nrPDB Length = 251 Score = 76.7 bits (187), Expect = 3e-14, Method: Composition-based stats. Identities = 43/166 (25%), Positives = 75/166 (45%), Gaps = 19/166 (11%) Query: 115 GADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLR---RKTKEDQERLRKGGATA 171 A + + G +A A ++ +K L + GANV+ R R ++ Q G Sbjct: 85 NAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELP 144 Query: 172 LMDAAEKGHVEVLKILLDEM--GADVNACDNMGRNALIHALLSSDDSDVEAITHL----- 224 L AA +V+ LL+ A + A D+ G N ++HAL+ D+ E I + Sbjct: 145 LSLAACTKQWDVVSYLLENPHQPASLQATDSQG-NTVLHALVMISDNSAENIALVTSMYD 203 Query: 225 -LLDHGADV-------NVRGERGKTPLILAVEKKHLGLVQRLLEQE 262 LL GA + ++R + TPL LA ++ + + + +L++E Sbjct: 204 GLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQRE 249 Score = 63.2 bits (152), Expect = 4e-10, Method: Composition-based stats. Identities = 35/173 (20%), Positives = 59/173 (34%), Gaps = 35/173 (20%) Query: 48 GANVNFQEEEG---GWTPLHNAVQMSREDIVELLLRHGADPVLRKKN------------- 91 VN Q + G + LH A++ V+LL+ +GA+ R Sbjct: 81 QPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYF 140 Query: 92 GATPFILAAIAGSVKLLKLFLSK---GADVNECDFYGFTAFMEAAVYGKVKALKF----- 143 G P LAA ++ L A + D G T + A Sbjct: 141 GELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTS 200 Query: 144 ----LYKRGAN--VNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDE 190 L + GA ++ + + + L T L AA++G +E+ + +L Sbjct: 201 MYDGLLQAGARLCPTVQLEDIRNLQDL-----TPLKLAAKEGKIEIFRHILQR 248 Score = 36.2 bits (82), Expect = 0.052, Method: Composition-based stats. Identities = 37/211 (17%), Positives = 60/211 (28%), Gaps = 44/211 (20%) Query: 116 ADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDA 175 D N D A G + L L + + + E E G T LM A Sbjct: 1 PDPNRFDRDR---LFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTE--GSTGKTCLMKA 55 Query: 176 AEKGHVEVLKILLDEMGAD---------VNAC---DNMGRNALIHALLSSDDSDVEAITH 223 V +L + D VNA D ++ +H + + Sbjct: 56 VLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAI---EKRSLQCVK 112 Query: 224 LLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVEL 283 LL+++GA+V+ R + + + G+ L LA Sbjct: 113 LLVENGANVHARA-----------------CGRFFQKGQGTCF----YFGELPLSLAACT 151 Query: 284 KLKKIAELLC---KRGASTDCGDLVMTARRN 311 K + L + AS D + Sbjct: 152 KQWDVVSYLLENPHQPASLQATDSQGNTVLH 182 >6EII-A nrPDB Length = 352 Score = 76.7 bits (187), Expect = 3e-14, Method: Composition-based stats. Identities = 44/298 (14%), Positives = 89/298 (29%), Gaps = 84/298 (28%) Query: 367 EKYKIADTSEGGIYLGFYEKQEVA-------VKTFCEGSPRAQREVSCLQSSRENSHLVT 419 + Y++ G Y +E + + +RE+ L++ R +++T Sbjct: 60 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIIT 119 Query: 420 FYGSESH--RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL 477 + T + + D R + I KA+ H Sbjct: 120 LADIVKDPVSRTPALVFEHVNNT-------DFKQLYQTLTDYDIRFYMYEILKALDYCH- 171 Query: 478 SCGYTHQDLQPQNILID-SKKAAHLADFDK--------------SIKWAGDP-------- 514 S G H+D++P N++ID + L D+ + ++ P Sbjct: 172 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 231 Query: 515 QEVKRDLEDLGRLVLYVVKKGSISF------------------EDLKAQSNEEVVQLSP- 555 + D+ LG ++ ++ + F EDL ++ ++L P Sbjct: 232 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 291 Query: 556 -------------------------DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWT 588 E D + +L R + + HP+F+T Sbjct: 292 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 349 >4F0G-A nrPDB Length = 287 Score = 76.7 bits (187), Expect = 3e-14, Method: Composition-based stats. Identities = 40/279 (14%), Positives = 85/279 (30%), Gaps = 64/279 (22%) Query: 360 KLKFFIDEKYKIADTSEGGIYLGFYEKQ------EVAVK-----------TFCEGSPRAQ 402 +L D + + G + ++ + VA+K E Q Sbjct: 12 RLPTLADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQ 71 Query: 403 REVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFAR 462 REV + S+ + ++V YG + + + HR D + + Sbjct: 72 REV-FIMSNLNHPNIVKLYGLMHNPP--RMVMEFVP----CGDLYHRLLDKAHPIKWSVK 124 Query: 463 -NVLSSIFKAVQEL-HLSCGYTHQDLQPQNILI-----DSKKAAHLADFDKS-------- 507 ++ I ++ + + + H+DL+ NI + ++ A +ADF S Sbjct: 125 LRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVS 184 Query: 508 -------------IKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKA---------Q 545 I + K D ++LY + G F++ + Sbjct: 185 GLLGNFQWMAPETIGAEEESYTEKADTYSF-AMILYTILTGEGPFDEYSYGKIKFINMIR 243 Query: 546 SNEEVVQLSPD--EETKDLIHRLFHPGEHVRDCLSDLLG 582 + D +++I + R S ++ Sbjct: 244 EEGLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVK 282 >4JLC-A nrPDB Length = 657 Score = 76.7 bits (187), Expect = 4e-14, Method: Composition-based stats. Identities = 39/211 (18%), Positives = 66/211 (31%), Gaps = 46/211 (21%) Query: 371 IADTSEGGIYLGFYEKQE--VAVKTFCEGS-----PRAQREVSCLQSSRENSHLVTFYGS 423 + + ++ G ++K AVK F S RE L+ + ++V + Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKL-NHKNIVKLFAI 74 Query: 424 ESHRGHLF--VCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 E + + C + E EF VL + + L + G Sbjct: 75 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL-IVLRDVVGGMNHLREN-GI 132 Query: 482 THQDLQPQNILI----DSKKAAHLADFDKSIKWAGDPQEVK------------------- 518 H+D++P NI+ D + L DF + + D Q V Sbjct: 133 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 192 Query: 519 ----------RDLEDLGRLVLYVVKKGSISF 539 DL +G + Y GS+ F Sbjct: 193 KDHQKKYGATVDLWSVG-VTFYHAATGSLPF 222 >3RAW-A nrPDB Length = 381 Score = 76.3 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 52/344 (15%), Positives = 96/344 (27%), Gaps = 109/344 (31%) Query: 357 MIGKLKFFIDEKYKIADTSEGGIYLGFYE-------KQEVAVKTFCEGSPR---AQREVS 406 ++ ++ ++ E+Y+I G + E K +VA+K A+ E++ Sbjct: 41 LVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEIN 100 Query: 407 CLQSSRENSHLVTFYGSESHRGHLF-----VCVTLCEQTLEACLDVHRGEDVENEEDEFA 461 L+ +E F F + L + L + + Sbjct: 101 VLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLP---HV 157 Query: 462 RNVLSSIFKAVQELHLSCGYTHQDLQPQNILI-------------------DSKKAAHLA 502 R++ + A++ LH + TH DL+P+NIL + +A Sbjct: 158 RHMAYQLCHALRFLHENQ-LTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVA 216 Query: 503 DFDKS-------IKWAGDPQEV------------KRDLEDLGRLVLYVVKKGSISFED-- 541 DF + D+ +G +L+ +G F+ Sbjct: 217 DFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGC-ILFEYYRGFTLFQTHE 275 Query: 542 ----------------------LKAQSNEEVVQLSPDEETKD------------------ 561 + Q L DE + D Sbjct: 276 NREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQD 335 Query: 562 ---------LIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTL 596 L+ R+ R L++ L HPFF R+ Sbjct: 336 SLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSF 379 >3KRL-A nrPDB Length = 335 Score = 76.3 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 43/306 (14%), Positives = 92/306 (30%), Gaps = 63/306 (20%) Query: 336 WKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQ-------- 387 WK S+ G + + P K +F + + T G + E Sbjct: 16 WKIIESYEGNSYTFIDPTQLPYNEKWEFPRN-NLQFGKTLGAGAFGKVVEATAFGLGKED 74 Query: 388 ---EVAVKTFCEGSPRAQRE-----VSCLQSSRENSHLVTFYGSESHRGHLFVCVTLC-- 437 +VAVK + ++E + + ++ ++V G+ +H G + V C Sbjct: 75 AVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCY 134 Query: 438 -------EQTLEACLDVHRGEDVENEEDEFARNVLS---SIFKAVQELHLSCGYTHQDLQ 487 + L+ EE +R++L + + + L S H+D+ Sbjct: 135 GDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFL-ASKNCIHRDVA 193 Query: 488 PQNILIDSKKAAHLADFDKSIKWAGDPQE------------------------VKRDLED 523 +N+L+ + A + DF + D V+ D+ Sbjct: 194 ARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWS 253 Query: 524 LGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETK---------DLIHRLFHPGEHVR 574 G L+ + G + + S + + + ++ + R Sbjct: 254 YGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR 313 Query: 575 DCLSDL 580 + Sbjct: 314 PTFQQI 319 >6BFN-A nrPDB Length = 342 Score = 76.3 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 31/152 (20%), Positives = 52/152 (34%), Gaps = 10/152 (6%) Query: 366 DEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGS--------PRAQREVSCLQSSRENSHL 417 E+ KI + G +Y AVK E + EV L R + ++ Sbjct: 25 SEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFR-HPNI 83 Query: 418 VTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL 477 V F G + G + + + ++L +A+Q LH Sbjct: 84 VDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQ 143 Query: 478 -SCGYTHQDLQPQNILIDSKKAAHLADFDKSI 508 S H D++ N+L+D + L DF + Sbjct: 144 DSPSLIHGDIKSSNVLLDERLTPKLGDFGLAR 175 >3HNG-A nrPDB Length = 360 Score = 76.3 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 53/333 (15%), Positives = 94/333 (28%), Gaps = 114/333 (34%) Query: 363 FFIDEKYKIADTSEGGIYLGFYEK-----------QEVAVKTFCEGSPRAQ-----REVS 406 F E+ K+ + G + + + VAVK EG+ ++ E+ Sbjct: 23 EFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELK 82 Query: 407 CLQSSRENSHLVTFYGS-ESHRGHLFVCVTL----------------------------- 436 L + ++V G+ G L V V Sbjct: 83 ILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEP 142 Query: 437 ----CEQTLE-------------------ACLDVHRGEDVENEED-----------EFAR 462 E LE + DVE EED E Sbjct: 143 KKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLI 202 Query: 463 NVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV----- 517 + + + ++ L S H+DL +NIL+ + DF + +P V Sbjct: 203 SYSFQVARGMEFL-SSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDT 261 Query: 518 -------------------KRDLEDLGRLVLYVVKKGSISF------EDLKAQSNEEVVQ 552 K D+ G L+ + G + ED ++ E + Sbjct: 262 RLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRM 321 Query: 553 LSPDEETKDLIHRLF---HPGEHVRDCLSDLLG 582 +P+ T ++ + H R ++L+ Sbjct: 322 RAPEYSTPEIYQIMLDCWHRDPKERPRFAELVE 354 >3PP0-A nrPDB Length = 338 Score = 76.3 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 41/271 (15%), Positives = 84/271 (30%), Gaps = 52/271 (19%) Query: 370 KIADTSEGGIYLGFYEKQ------EVAVKTFCE-GSPRAQREV---SCLQSSRENSHLVT 419 + + G +Y G + VA+K E SP+A +E+ + + + + ++ Sbjct: 24 VLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSR 83 Query: 420 FYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSC 479 G + + L CL H E+ + N I K + L Sbjct: 84 LLGICLT-STVQLVTQLMPYG---CLLDHVRENRGRLGSQDLLNWCMQIAKGMSYL-EDV 138 Query: 480 GYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV---------------------- 517 H+DL +N+L+ S + DF + D E Sbjct: 139 RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF 198 Query: 518 --KRDLEDLGRLVLYVVKKGSISFEDL----------KAQSNEEVVQLSPDEETKDLIHR 565 + D+ G V ++ G+ ++ + K + + + D ++ + Sbjct: 199 THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTID--VYMIMVK 256 Query: 566 LFHPGEHVRDCLSDLLGHPFFWTWESRYRTL 596 + R +L+ F R + Sbjct: 257 CWMIDSECRPRFRELVS-EFSRMARDPQRFV 286 >4EUU-A nrPDB Length = 319 Score = 76.3 bits (186), Expect = 5e-14, Method: Composition-based stats. Identities = 37/211 (17%), Positives = 66/211 (31%), Gaps = 46/211 (21%) Query: 371 IADTSEGGIYLGFYEKQE--VAVKTFCEGS-----PRAQREVSCLQSSRENSHLVTFYGS 423 + + ++ G ++K A+K F S RE L+ + ++V + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL-NHKNIVKLFAI 75 Query: 424 ESHRGHLF--VCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 E + + C + E EF VL + + L + G Sbjct: 76 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL-IVLRDVVGGMNHLREN-GI 133 Query: 482 THQDLQPQNILI----DSKKAAHLADFDKSIKWAGDPQEVK------------------- 518 H++++P NI+ D + L DF + + D Q V Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 193 Query: 519 ----------RDLEDLGRLVLYVVKKGSISF 539 DL +G + Y GS+ F Sbjct: 194 KDHQKKYGATVDLWSIG-VTFYHAATGSLPF 223 >4EUT-A nrPDB Length = 396 Score = 76.3 bits (186), Expect = 5e-14, Method: Composition-based stats. Identities = 37/211 (17%), Positives = 66/211 (31%), Gaps = 46/211 (21%) Query: 371 IADTSEGGIYLGFYEKQE--VAVKTFCEGS-----PRAQREVSCLQSSRENSHLVTFYGS 423 + + ++ G ++K A+K F S RE L+ + ++V + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL-NHKNIVKLFAI 75 Query: 424 ESHRGHLF--VCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 E + + C + E EF VL + + L + G Sbjct: 76 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL-IVLRDVVGGMNHLREN-GI 133 Query: 482 THQDLQPQNILI----DSKKAAHLADFDKSIKWAGDPQEVK------------------- 518 H++++P NI+ D + L DF + + D Q V Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 193 Query: 519 ----------RDLEDLGRLVLYVVKKGSISF 539 DL +G + Y GS+ F Sbjct: 194 KDHQKKYGATVDLWSIG-VTFYHAATGSLPF 223 >4R7H-A nrPDB Length = 343 Score = 75.9 bits (185), Expect = 6e-14, Method: Composition-based stats. Identities = 46/313 (14%), Positives = 94/313 (30%), Gaps = 70/313 (22%) Query: 336 WKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQ-------- 387 WK S+ G + + P K +F + + T G + E Sbjct: 20 WKIIESYEGNSYTFIDPTQLPYNEKWEFPRN-NLQFGKTLGAGAFGKVVEATAFGLGKED 78 Query: 388 ---EVAVKTFCEGSPRAQRE-----VSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQ 439 +VAVK + ++E + + ++ ++V G+ +H G + V C Sbjct: 79 AVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTY 138 Query: 440 T-LEACL----------DVHRGEDVENEEDEFAR--------NVLSSIFKAVQELHLSCG 480 L L + G+D E + E R + S + + + L S Sbjct: 139 GDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFL-ASKN 197 Query: 481 YTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE------------------------ 516 H+D+ +N+L+ + A + DF + D Sbjct: 198 CIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSVYT 257 Query: 517 VKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETK---------DLIHRLF 567 V+ D+ G L+ + G + + S + + + ++ + Sbjct: 258 VQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACW 317 Query: 568 HPGEHVRDCLSDL 580 R + Sbjct: 318 ALEPTHRPTFQQI 330 >4G3E-A nrPDB Length = 352 Score = 75.9 bits (185), Expect = 6e-14, Method: Composition-based stats. Identities = 38/251 (15%), Positives = 72/251 (28%), Gaps = 48/251 (19%) Query: 370 KIADTSEGGI--YLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHR 427 ++ S G + + AVK R + V+C S +V YG+ Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVACAGLSS--PRIVPLYGAVREG 138 Query: 428 GHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQ 487 + + + L E L + + ++ A L + ++ LH + H D++ Sbjct: 139 PWVNIFMELLEGGSLGQL----IKQMGCLPEDRALYYLGQALEGLEYLH-TRRILHGDVK 193 Query: 488 PQNILIDSKKA-AHLADFD--KSIKW-------------------------AGDPQEVKR 519 N+L+ S + A L DF ++ G P + K Sbjct: 194 ADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKV 253 Query: 520 DLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQ----------LSPDEETKDLIHRLFHP 569 D+ ++ + G + + S T I Sbjct: 254 DIWS-SCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRK 312 Query: 570 GEHVRDCLSDL 580 R +L Sbjct: 313 EPVHRASAMEL 323 >6O8B-A nrPDB Length = 665 Score = 75.5 bits (184), Expect = 7e-14, Method: Composition-based stats. Identities = 37/211 (17%), Positives = 67/211 (31%), Gaps = 46/211 (21%) Query: 371 IADTSEGGIYLGFYEKQE--VAVKTFCEGS-----PRAQREVSCLQSSRENSHLVTFYGS 423 + + ++ G ++K A+K F S RE L+ + ++V + Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL-NHKNIVKLFAI 81 Query: 424 ESHRGHLF--VCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 E + + C + E EF VL + + L + G Sbjct: 82 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL-IVLRDVVGGMNHLREN-GI 139 Query: 482 THQDLQPQNILI----DSKKAAHLADFDKSIKWAGDPQEVK------------------- 518 H++++P NI+ D + L DF + + D Q V+ Sbjct: 140 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVLR 199 Query: 519 ----------RDLEDLGRLVLYVVKKGSISF 539 DL +G + Y GS+ F Sbjct: 200 KDHQKKYGATVDLWSIG-VTFYHAATGSLPF 229 >6NT9-A nrPDB Length = 742 Score = 75.1 bits (183), Expect = 1e-13, Method: Composition-based stats. Identities = 37/211 (17%), Positives = 66/211 (31%), Gaps = 46/211 (21%) Query: 371 IADTSEGGIYLGFYEKQE--VAVKTFCEGS-----PRAQREVSCLQSSRENSHLVTFYGS 423 + + ++ G ++K A+K F S RE L+ + ++V + Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL-NHKNIVKLFAI 73 Query: 424 ESHRGHLF--VCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 E + + C + E EF VL + + L + G Sbjct: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL-IVLRDVVGGMNHLREN-GI 131 Query: 482 THQDLQPQNILI----DSKKAAHLADFDKSIKWAGDPQEVK------------------- 518 H++++P NI+ D + L DF + + D Q V Sbjct: 132 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 Query: 519 ----------RDLEDLGRLVLYVVKKGSISF 539 DL +G + Y GS+ F Sbjct: 192 KDHQKKYGATVDLWSIG-VTFYHAATGSLPF 221 >6BO5-A nrPDB Length = 695 Score = 75.1 bits (183), Expect = 1e-13, Method: Composition-based stats. Identities = 42/166 (25%), Positives = 75/166 (45%), Gaps = 19/166 (11%) Query: 115 GADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLR---RKTKEDQERLRKGGATA 171 A + + G +A A ++ +K L + GA+V+LR R ++ Q G Sbjct: 114 NAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELP 173 Query: 172 LMDAAEKGHVEVLKILLDEM--GADVNACDNMGRNALIHALLSSDDSDVEAITHL----- 224 L AA +V+ LL+ A + A D++G N ++HAL+ D+ E + Sbjct: 174 LSLAACTKQWDVVTYLLENPHQPASLEATDSLG-NTVLHALVMIADNSPENSALVIHMYD 232 Query: 225 -LLDHGADV-------NVRGERGKTPLILAVEKKHLGLVQRLLEQE 262 LL GA + + +G TPL LA ++ + + + +L++E Sbjct: 233 GLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQRE 278 Score = 63.2 bits (152), Expect = 4e-10, Method: Composition-based stats. Identities = 41/171 (23%), Positives = 62/171 (36%), Gaps = 31/171 (18%) Query: 48 GANVNFQEEE---GGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN------------- 91 VN Q + G + LH A++ V+LL+ +GAD LR Sbjct: 110 KPLVNAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYF 169 Query: 92 GATPFILAAIAGSVKLLKLFLSK---GADVNECDFYGFTAFM----EAAVYGKVKALKF- 143 G P LAA ++ L A + D G T A + AL Sbjct: 170 GELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIH 229 Query: 144 ----LYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDE 190 L + GA + T + +E G T L AA++G +E+ + +L Sbjct: 230 MYDGLLQMGARLCP---TVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQR 277 Score = 37.4 bits (85), Expect = 0.021, Method: Composition-based stats. Identities = 20/85 (23%), Positives = 34/85 (40%), Gaps = 13/85 (15%) Query: 231 DVNVRGERGKTPLILAV---EKKHLGLVQRLLEQEHIE------INDTDSD----GKTAL 277 G GKT L+ AV + + LL+ + +N +D G +AL Sbjct: 69 SAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKPLVNAQCTDEFYQGHSAL 128 Query: 278 LLAVELKLKKIAELLCKRGASTDCG 302 +A+E + + +LL + GA Sbjct: 129 HIAIEKRSLQCVKLLVENGADVHLR 153 >5HI9-A nrPDB Length = 770 Score = 75.1 bits (183), Expect = 1e-13, Method: Composition-based stats. Identities = 42/166 (25%), Positives = 75/166 (45%), Gaps = 19/166 (11%) Query: 115 GADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLR---RKTKEDQERLRKGGATA 171 A + + G +A A ++ +K L + GA+V+LR R ++ Q G Sbjct: 154 NAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELP 213 Query: 172 LMDAAEKGHVEVLKILLDEM--GADVNACDNMGRNALIHALLSSDDSDVEAITHL----- 224 L AA +V+ LL+ A + A D++G N ++HAL+ D+ E + Sbjct: 214 LSLAACTKQWDVVTYLLENPHQPASLEATDSLG-NTVLHALVMIADNSPENSALVIHMYD 272 Query: 225 -LLDHGADV-------NVRGERGKTPLILAVEKKHLGLVQRLLEQE 262 LL GA + + +G TPL LA ++ + + + +L++E Sbjct: 273 GLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQRE 318 Score = 63.2 bits (152), Expect = 4e-10, Method: Composition-based stats. Identities = 41/171 (23%), Positives = 62/171 (36%), Gaps = 31/171 (18%) Query: 48 GANVNFQEEE---GGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN------------- 91 VN Q + G + LH A++ V+LL+ +GAD LR Sbjct: 150 KPLVNAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYF 209 Query: 92 GATPFILAAIAGSVKLLKLFLSK---GADVNECDFYGFTAFM----EAAVYGKVKALKF- 143 G P LAA ++ L A + D G T A + AL Sbjct: 210 GELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIH 269 Query: 144 ----LYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDE 190 L + GA + T + +E G T L AA++G +E+ + +L Sbjct: 270 MYDGLLQMGARLCP---TVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQR 317 Score = 37.4 bits (85), Expect = 0.021, Method: Composition-based stats. Identities = 20/85 (23%), Positives = 34/85 (40%), Gaps = 13/85 (15%) Query: 231 DVNVRGERGKTPLILAV---EKKHLGLVQRLLEQEHIE------INDTDSD----GKTAL 277 G GKT L+ AV + + LL+ + +N +D G +AL Sbjct: 109 SAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKPLVNAQCTDEFYQGHSAL 168 Query: 278 LLAVELKLKKIAELLCKRGASTDCG 302 +A+E + + +LL + GA Sbjct: 169 HIAIEKRSLQCVKLLVENGADVHLR 193 >4OW8-A nrPDB Length = 283 Score = 75.1 bits (183), Expect = 1e-13, Method: Composition-based stats. Identities = 39/275 (14%), Positives = 82/275 (29%), Gaps = 56/275 (20%) Query: 340 SSHWGAALKDLHRIYRPM----IGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFC 395 S G L +R+ R + +G++ +D + + + + ++ F Sbjct: 2 SPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNR--LGRRVAVKVLKSEFSSDPEFIERF- 58 Query: 396 EGSPRAQREVSCLQSSRENSHLVTFYGSESHR-----GHLFVCVTLCEQTLEACLDVHRG 450 RA+ + + + + + + + ++ + L + G Sbjct: 59 ----RAEARTTAM---LNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTG 111 Query: 451 EDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKW 510 A ++L +A+Q H + G H+D++P NILI + DF + Sbjct: 112 RL----SLRHALDMLEQTGRALQIAHAA-GLVHRDVKPGNILITPTGQVKITDFGIAKAV 166 Query: 511 AGDP-----------QEV------------KRDLEDLGRLVLYVVKKGSISFEDL----- 542 P Q + D+ LG +V Y G F Sbjct: 167 DAAPVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLG-VVGYEAVSGKRPFAGDGALTV 225 Query: 543 ---KAQSNEEVVQLSPDEETKDLIHRLFHPGEHVR 574 + + ++LI +R Sbjct: 226 AMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMR 260 >4X3F-A nrPDB Length = 337 Score = 75.1 bits (183), Expect = 1e-13, Method: Composition-based stats. Identities = 39/275 (14%), Positives = 82/275 (29%), Gaps = 56/275 (20%) Query: 340 SSHWGAALKDLHRIYRPM----IGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFC 395 S G L +R+ R + +G++ +D + + + + ++ F Sbjct: 3 SPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNR--LGRRVAVKVLKSEFSSDPEFIERF- 59 Query: 396 EGSPRAQREVSCLQSSRENSHLVTFYGSESHR-----GHLFVCVTLCEQTLEACLDVHRG 450 RA+ + + + + + + + ++ + L + G Sbjct: 60 ----RAEARTTAM---LNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTG 112 Query: 451 EDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKW 510 A ++L +A+Q H + G H+D++P NILI + DF + Sbjct: 113 RL----SLRHALDMLEQTGRALQIAHAA-GLVHRDVKPGNILITPTGQVKITDFGIAKAV 167 Query: 511 AGDP-----------QEV------------KRDLEDLGRLVLYVVKKGSISFEDL----- 542 P Q + D+ LG +V Y G F Sbjct: 168 DAAPVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLG-VVGYEAVSGKRPFAGDGALTV 226 Query: 543 ---KAQSNEEVVQLSPDEETKDLIHRLFHPGEHVR 574 + + ++LI +R Sbjct: 227 AMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMR 261 >6B2Q-A nrPDB Length = 317 Score = 75.1 bits (183), Expect = 1e-13, Method: Composition-based stats. Identities = 39/275 (14%), Positives = 82/275 (29%), Gaps = 56/275 (20%) Query: 340 SSHWGAALKDLHRIYRPM----IGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFC 395 S G L +R+ R + +G++ +D + + + + ++ F Sbjct: 23 SPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNR--LGRRVAVKVLKSEFSSDPEFIERF- 79 Query: 396 EGSPRAQREVSCLQSSRENSHLVTFYGSESHR-----GHLFVCVTLCEQTLEACLDVHRG 450 RA+ + + + + + + + ++ + L + G Sbjct: 80 ----RAEARTTAM---LNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTG 132 Query: 451 EDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKW 510 A ++L +A+Q H + G H+D++P NILI + DF + Sbjct: 133 RL----SLRHALDMLEQTGRALQIAHAA-GLVHRDVKPGNILITPTGQVKITDFGIAKAV 187 Query: 511 AGDP-----------QEV------------KRDLEDLGRLVLYVVKKGSISFEDL----- 542 P Q + D+ LG +V Y G F Sbjct: 188 DAAPVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLG-VVGYEAVSGKRPFAGDGALTV 246 Query: 543 ---KAQSNEEVVQLSPDEETKDLIHRLFHPGEHVR 574 + + ++LI +R Sbjct: 247 AMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMR 281 >6FEX-A nrPDB Length = 321 Score = 74.7 bits (182), Expect = 1e-13, Method: Composition-based stats. Identities = 46/252 (18%), Positives = 78/252 (30%), Gaps = 58/252 (23%) Query: 389 VAVKTFCEGSPR-----AQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQT-LE 442 VAVK + + +EV + ++ +++ G L + E L Sbjct: 60 VAVKILRPDATKNARNDFLKEVKIMSRLKD-PNIIRLLGVCVQDDPLCMITDYMENGDLN 118 Query: 443 ACLDVHRGEDVENE--------EDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILID 494 L H+ ED E +V + I ++ L + + H+DL +N L+ Sbjct: 119 QFLSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYL-ATLNFVHRDLATRNCLVG 177 Query: 495 SKKAAHLADFDKSIKW-AGDPQEVK-----------------------RDLEDLGRLVLY 530 +ADF S AGD V+ D+ G + Sbjct: 178 ENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWE 237 Query: 531 VVK-KGSISFEDLK-AQSNEEVVQLSPDEETK--------------DLIHRLFHPGEHVR 574 V+ + F L Q E + D+ + +L+ R + R Sbjct: 238 VLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQR 297 Query: 575 DCLSDLLGHPFF 586 S L H F Sbjct: 298 PPFSQL--HRFL 307 >6FYV-A nrPDB Length = 337 Score = 74.4 bits (181), Expect = 2e-13, Method: Composition-based stats. Identities = 50/328 (15%), Positives = 87/328 (26%), Gaps = 109/328 (33%) Query: 368 KYKIADTSEGGIYLGFYE-------KQEVAVKTFCEGSPR---AQREVSCLQSS-RENSH 416 +Y+I DT G + E VAVK A+ E+ L+ + + Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPN 74 Query: 417 ----LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAV 472 V H GH+ + L + D + + + R + I +++ Sbjct: 75 SVFRCVQMLEWFDHHGHVCIVFELLGLST---YDFIKENSFLPFQIDHIRQMAYQICQSI 131 Query: 473 QELHLSCGYTHQDLQPQNILID-------------------SKKAAHLADFDKSI----- 508 LH + TH DL+P+NIL + DF + Sbjct: 132 NFLHHN-KLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEH 190 Query: 509 --KWAGDPQEVK------------RDLEDLGRLVLYVVKKGSISFED--------LKAQS 546 D+ +G +++ G F+ + + Sbjct: 191 HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYL-GFTVFQTHDSKEHLAMMERI 249 Query: 547 NEEVVQ--------------------------------LSPDEETK-----------DLI 563 + Q P +E DL+ Sbjct: 250 LGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLV 309 Query: 564 HRLFHPGEHVRDCLSDLLGHPFFWTWES 591 R+ R L + L HPFF + Sbjct: 310 RRMLEYDPTQRITLDEALQHPFFDLLKK 337 >6J5U-C nrPDB Length = 426 Score = 74.4 bits (181), Expect = 2e-13, Method: Composition-based stats. Identities = 43/279 (15%), Positives = 83/279 (29%), Gaps = 67/279 (24%) Query: 367 EKYKIADTSEGGIYLGFYEKQE-----------VAVKTF----CEGSPRAQREVSCLQSS 411 + + + G ++ G+ ++ VAVK +G EV+ L Sbjct: 88 QDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEWLTEVNYLGQL 147 Query: 412 RENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 471 + +LV G + + + + RG V K Sbjct: 148 S-HPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRM--KVAVGAAKG 204 Query: 472 VQELHLSCG-YTHQDLQPQNILIDSKKAAHLADFDKSI-KWAGD---------------- 513 + LH + ++D + NIL+D+ A L+DF + GD Sbjct: 205 LTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGYAA 264 Query: 514 PQEV-------KRDLEDLGRLVL-----------------YVVKKGSISFEDLKAQ---- 545 P+ V K D+ G ++L Y + + + K + Sbjct: 265 PEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATPYLGDKRKLFRI 324 Query: 546 ---SNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLL 581 +L + +P +R +S++L Sbjct: 325 MDTKLGGQYPQKGAFTAANLALQCLNPDAKLRPKMSEVL 363 >6DBM-A nrPDB Length = 318 Score = 74.0 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 42/265 (15%), Positives = 81/265 (30%), Gaps = 65/265 (24%) Query: 385 EKQEVAVKTFCEGSPRAQR-----EVSCLQSSRENSHLVTFYGSESHRGH--LFVCVTLC 437 + VAVK + R E+ L+ + + H++ + G G L + + Sbjct: 59 TGEMVAVKALKADAGPQHRSGWKQEIDILR-TLYHEHIIKYKGCCEDAGAASLQLVMEYV 117 Query: 438 EQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKK 497 L + D + + I + + LH S Y H+DL +N+L+D+ + Sbjct: 118 P--LGSLRDYLPRHSIGLAQLLL---FAQQICEGMAYLH-SQHYIHRDLAARNVLLDNDR 171 Query: 498 AAHLADFDKSIKWAGDPQEVK-------------------------RDLEDLGRLVLYVV 532 + DF + + + D+ G + LY + Sbjct: 172 LVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFG-VTLYEL 230 Query: 533 KK-----GSIS--FEDLKAQSNEEVVQLSPDE----------------ETKDLIHRLFHP 569 S F +L + ++ L E E L+ + Sbjct: 231 LTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPAEVYHLMKNCWET 290 Query: 570 GEHVRDCLSDLLGHPFFWTWESRYR 594 R +L+ P T +Y+ Sbjct: 291 EASFRPTFENLI--PILKTVHEKYQ 313 >2ETB-A nrPDB Length = 256 Score = 74.0 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 42/166 (25%), Positives = 75/166 (45%), Gaps = 19/166 (11%) Query: 115 GADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLR---RKTKEDQERLRKGGATA 171 A + + G +A A ++ +K L + GA+V+LR R ++ Q G Sbjct: 80 NAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELP 139 Query: 172 LMDAAEKGHVEVLKILLDEM--GADVNACDNMGRNALIHALLSSDDSDVEAITHL----- 224 L AA +V+ LL+ A + A D++G N ++HAL+ D+ E + Sbjct: 140 LSLAACTKQWDVVTYLLENPHQPASLEATDSLG-NTVLHALVMIADNSPENSALVIHMYD 198 Query: 225 -LLDHGADV-------NVRGERGKTPLILAVEKKHLGLVQRLLEQE 262 LL GA + + +G TPL LA ++ + + + +L++E Sbjct: 199 GLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQRE 244 Score = 62.4 bits (150), Expect = 6e-10, Method: Composition-based stats. Identities = 41/171 (23%), Positives = 62/171 (36%), Gaps = 31/171 (18%) Query: 48 GANVNFQEEE---GGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN------------- 91 VN Q + G + LH A++ V+LL+ +GAD LR Sbjct: 76 KPLVNAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYF 135 Query: 92 GATPFILAAIAGSVKLLKLFLSK---GADVNECDFYGFTAFM----EAAVYGKVKALKF- 143 G P LAA ++ L A + D G T A + AL Sbjct: 136 GELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIH 195 Query: 144 ----LYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDE 190 L + GA + T + +E G T L AA++G +E+ + +L Sbjct: 196 MYDGLLQMGARLCP---TVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQR 243 Score = 37.0 bits (84), Expect = 0.029, Method: Composition-based stats. Identities = 20/85 (23%), Positives = 34/85 (40%), Gaps = 13/85 (15%) Query: 231 DVNVRGERGKTPLILAV---EKKHLGLVQRLLEQEHIE------INDTDSD----GKTAL 277 G GKT L+ AV + + LL+ + +N +D G +AL Sbjct: 35 SAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKPLVNAQCTDEFYQGHSAL 94 Query: 278 LLAVELKLKKIAELLCKRGASTDCG 302 +A+E + + +LL + GA Sbjct: 95 HIAIEKRSLQCVKLLVENGADVHLR 119 >3QA8-A nrPDB Length = 676 Score = 74.0 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 36/209 (17%), Positives = 70/209 (33%), Gaps = 41/209 (19%) Query: 368 KYKIADTSEGGIYLGFYEK--QEVAVKTFCEGSPRAQREVSCL----QSSRENSHLVTFY 421 K ++ G + ++ ++VA+K + RE CL + ++V+ Sbjct: 19 KERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVVSAR 78 Query: 422 GS------ESHRGHLFVCVTLCEQT-LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 + + + CE L L+ E+ ++ R +LS I A++ Sbjct: 79 EVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQF--ENCCGLKEGPIRTLLSDISSALRY 136 Query: 475 LHLSCGYTHQDLQPQNILIDSKKAA---HLADFD---------KSIKWAGDPQE------ 516 LH + H+DL+P+NI++ + D ++ G Q Sbjct: 137 LHEN-RIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPELL 195 Query: 517 ------VKRDLEDLGRLVLYVVKKGSISF 539 V D G + + G F Sbjct: 196 EQKKYTVTVDYWSFG-TLAFECITGFRPF 223 >4E20-A nrPDB Length = 290 Score = 73.6 bits (179), Expect = 3e-13, Method: Composition-based stats. Identities = 32/182 (17%), Positives = 60/182 (32%), Gaps = 40/182 (21%) Query: 385 EKQEVAVKTFCEGSPRA-----QREVSCLQSSRENSHLVTFYGSESHRGH--LFVCVTLC 437 + VAVK EG QRE+ L+ + + H+V + G +G + + + Sbjct: 36 TGEMVAVKALKEGCGPQLRSGWQREIEILR-TLYHEHIVKYKGCCEDQGEKSVQLVMEYV 94 Query: 438 EQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKK 497 L + D V + I + + LH Y H+ L +N+L+D+ + Sbjct: 95 P--LGSLRDYLPRHCVGLAQLLL---FAQQICEGMAYLHAQH-YIHRALAARNVLLDNDR 148 Query: 498 AAHLADFDKSIKWAGDPQEVK-------------------------RDLEDLGRLVLYVV 532 + DF + + + D+ G + LY + Sbjct: 149 LVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFG-VTLYEL 207 Query: 533 KK 534 Sbjct: 208 LT 209 >4TPT-A nrPDB Length = 303 Score = 73.6 bits (179), Expect = 3e-13, Method: Composition-based stats. Identities = 27/147 (18%), Positives = 48/147 (32%), Gaps = 11/147 (7%) Query: 362 KFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFY 421 K F + K+ + G + + ++ E EV ++ S ++ +++ F Sbjct: 10 KGFFGQAIKVTHKATGKVMVMKE-----LIRCDEETQKTFLTEVKVMR-SLDHPNVLKFI 63 Query: 422 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 G L + E ++ + I + LH S Sbjct: 64 GVLYKDKKLNLLTEYIEGGTLKDFL----RSMDPFPWQQKVRFAKGIASGMAYLH-SMCI 118 Query: 482 THQDLQPQNILIDSKKAAHLADFDKSI 508 H+DL N LI K +ADF S Sbjct: 119 IHRDLNSHNCLIKLDKTVVVADFGLSR 145 >3SV0-A nrPDB Length = 483 Score = 73.6 bits (179), Expect = 3e-13, Method: Composition-based stats. Identities = 47/248 (18%), Positives = 89/248 (35%), Gaps = 46/248 (18%) Query: 370 KIADTSEGGIYLG--FYEKQEVAVK--TFCEGSPRAQREVSCLQSSRENSHL--VTFYGS 423 KI S G IYLG +EVA+K P+ E + + + + V ++G Sbjct: 14 KIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQLLYESKIYRILQGGTGIPNVRWFGV 73 Query: 424 ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTH 483 E + + + L +LE + + A + V+ +H S + H Sbjct: 74 E--GDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLA----DQMINRVEFVH-SKSFLH 126 Query: 484 QDLQPQNILID---SKKAAHLADFDKSIKWA----------------------------- 511 +D++P N L+ ++ DF + K+ Sbjct: 127 RDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARYASVNTHL 186 Query: 512 GDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGE 571 G Q + DLE LG +++Y +GS+ ++ LKA + ++ + +++ I L Sbjct: 187 GIEQSRRDDLESLGYVLMY-FLRGSLPWQGLKAGTKKQKYEKISEKKVATSIEALCRGYP 245 Query: 572 HVRDCLSD 579 Sbjct: 246 TEFASYFH 253 >4OLI-A nrPDB Length = 645 Score = 73.2 bits (178), Expect = 4e-13, Method: Composition-based stats. Identities = 41/265 (15%), Positives = 81/265 (30%), Gaps = 65/265 (24%) Query: 385 EKQEVAVKTFCEGSPRAQR-----EVSCLQSSRENSHLVTFYGSESHRGH--LFVCVTLC 437 + VAVK R E+ L+ + + H++ + G +G L + + Sbjct: 381 TGEMVAVKALKADCGPQHRSGWKQEIDILR-TLYHEHIIKYKGCCEDQGEKSLQLVMEYV 439 Query: 438 EQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKK 497 L + D + + I + + LH S Y H++L +N+L+D+ + Sbjct: 440 P--LGSLRDYLPRHSIGLAQLLL---FAQQICEGMAYLH-SQHYIHRNLAARNVLLDNDR 493 Query: 498 AAHLADFDKSIKWAGDPQEVK-------------------------RDLEDLGRLVLYVV 532 + DF + + + D+ G + LY + Sbjct: 494 LVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFG-VTLYEL 552 Query: 533 KK-----GSIS--FEDLKAQSNEEVVQLSPDE----------------ETKDLIHRLFHP 569 S F +L + ++ L E E L+ + Sbjct: 553 LTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWET 612 Query: 570 GEHVRDCLSDLLGHPFFWTWESRYR 594 R +L+ P T +Y+ Sbjct: 613 EASFRPTFENLI--PILKTVHEKYQ 635 Score = 54.7 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 30/213 (14%), Positives = 55/213 (25%), Gaps = 37/213 (17%) Query: 404 EVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARN 463 E + L S ++HL +G + E LDV + + + Sbjct: 115 ETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGP---LDVWLRRERGHVPMAWKMV 171 Query: 464 VLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA-------AHLADFDKSIKWAGDPQE 516 V + A+ L + H ++ +NIL+ L+D + + Sbjct: 172 VAQQLASALSYL-ENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREER 230 Query: 517 VKR--------------------DLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQL--- 553 V+R D G +L + G + E Q Sbjct: 231 VERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHR 290 Query: 554 ---SPDEETKDLIHRLFHPGEHVRDCLSDLLGH 583 + L + R +L Sbjct: 291 LPEPSCPQLATLTSQCLTYEPTQRPSFRTILRD 323 >6FER-A nrPDB Length = 309 Score = 73.2 bits (178), Expect = 4e-13, Method: Composition-based stats. Identities = 32/244 (13%), Positives = 69/244 (28%), Gaps = 55/244 (22%) Query: 389 VAVKTFCEGSPR-----AQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQT-LE 442 VAVK + + +E+ + ++ +++ L + E L Sbjct: 53 VAVKMLRADANKNARNDFLKEIKIMSRLKD-PNIIHLLAVCITDDPLCMITEYMENGDLN 111 Query: 443 ACLDVHRGEDVENEEDEFA-----RNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKK 497 L H + + + + + + I ++ L S + H+DL +N L+ Sbjct: 112 QFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYL-SSLNFVHRDLATRNCLVGKNY 170 Query: 498 AAHLADFDKSIKW-AGDPQEVK-----------------------RDLEDLGRLVLYVVK 533 +ADF S +GD ++ D+ G + Sbjct: 171 TIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFT 230 Query: 534 -KGSISFEDLK----------------AQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDC 576 + L Q+ + PD K ++ + R Sbjct: 231 FCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLS-CWRRDTKNRPS 289 Query: 577 LSDL 580 ++ Sbjct: 290 FQEI 293 >1LUF-A nrPDB Length = 343 Score = 73.2 bits (178), Expect = 4e-13, Method: Composition-based stats. Identities = 40/274 (14%), Positives = 80/274 (29%), Gaps = 66/274 (24%) Query: 371 IADTSEGGIYLGF------YEK-QEVAVKTFCEGSPR-----AQREVSCLQSSRENSHLV 418 I + + G ++ YE VAVK E + QRE + + +N ++V Sbjct: 55 IGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEF-DNPNIV 113 Query: 419 TFYGSESHRGHLFVCVTLCEQT-LEACLDVHRGEDV--ENEEDEFARN------------ 463 G + + + L L V + D R Sbjct: 114 KLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSC 173 Query: 464 -----VLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS--------IKW 510 + + + L + H+DL +N L+ +ADF S K Sbjct: 174 AEQLCIARQVAAGMAYL-SERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKA 232 Query: 511 AGD---------PQEV-------KRDLEDLGRLVLYVVKKGSISF------EDLKAQSNE 548 G+ P+ + + D+ G ++ + G + E + + Sbjct: 233 DGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDG 292 Query: 549 EVVQLSPD--EETKDLIHRLFHPGEHVRDCLSDL 580 ++ + E +L+ + R + Sbjct: 293 NILACPENCPLELYNLMRLCWSKLPADRPSFCSI 326 >2JD5-A nrPDB Length = 373 Score = 72.8 bits (177), Expect = 5e-13, Method: Composition-based stats. Identities = 46/324 (14%), Positives = 94/324 (29%), Gaps = 107/324 (33%) Query: 366 DEKYKIADTSEGGIYLGFYEKQE------VAVKTFCEG---SPRAQREVSCLQSSRENS- 415 D +Y + G + + ++ VA+K + A+ E+ LQ + Sbjct: 18 DARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADN 77 Query: 416 ---------HLVTFYGSESHRG----HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFAR 462 H++ +H+G H+ + + + L A + + + + + Sbjct: 78 TKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPL---IYVK 134 Query: 463 NVLSSIFKAVQELHLSCGYTHQDLQPQNIL---IDSKKA---AHLADFDKS--------- 507 + + + +H CG H D++P+N+L +DS + +AD + Sbjct: 135 QISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYTN 194 Query: 508 ----------IKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLK-----------AQS 546 G P D+ L+ + + G FE + AQ Sbjct: 195 SIQTREYRSPEVLLGAPWGCGADIWSTACLI-FELITGDFLFEPDEGHSYTKDDDHIAQI 253 Query: 547 NEEVVQLSPD-----------------------------------------EETK---DL 562 E + +L +E K D Sbjct: 254 IELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDF 313 Query: 563 IHRLFHPGEHVRDCLSDLLGHPFF 586 + + R L+ HP+ Sbjct: 314 LSPMLQLDPRKRADAGGLVNHPWL 337 >5FQD-C nrPDB Length = 341 Score = 72.4 bits (176), Expect = 6e-13, Method: Composition-based stats. Identities = 43/234 (18%), Positives = 82/234 (35%), Gaps = 52/234 (22%) Query: 360 KLKFFIDEKYKIADTSEGGIYLGFY------EKQEVAVKTFCEGSPRAQ-----REVSCL 408 K +F + KYK+ G + Y +EVAVK + + Q + L Sbjct: 12 KAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKIL 71 Query: 409 QSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 Q H+ +YG E + + + L +LE + A + Sbjct: 72 QGGVGIPHI-RWYGQEKD--YNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLA----DQM 124 Query: 469 FKAVQELHLSCGYTHQDLQPQNILID---SKKAAHLADFDKSIKWAGDP----------- 514 ++ +H + H+D++P N L+ L DF + K+ + Sbjct: 125 ISRIEYVHTK-NFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDK 183 Query: 515 ------------------QEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEV 550 Q + D+E LG +++Y + S+ ++ LKA + ++ Sbjct: 184 NLTGTARYASINAHLGIEQSRRDDMESLGYVLMY-FNRTSLPWQGLKAATKKQK 236 >5HLW-A nrPDB Length = 299 Score = 72.4 bits (176), Expect = 6e-13, Method: Composition-based stats. Identities = 43/272 (15%), Positives = 86/272 (31%), Gaps = 54/272 (19%) Query: 357 MIGKLKFFIDEKYKIADTSEGGIYLGFYEKQE-----VAVKTFCEGSPRAQREVS----- 406 +IG + I G +Y G + AVK+ + EVS Sbjct: 14 VIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIG--EVSQFLTE 71 Query: 407 -CLQSSRENSHLVTFYGS-ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNV 464 + + ++++ G G V + + + R E + Sbjct: 72 GIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHG--DLRNFIRNETHNPTVKDLIGFG 129 Query: 465 LSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE-------- 516 L + K ++ L S + H+DL +N ++D K +ADF + Sbjct: 130 L-QVAKGMKYL-ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGA 187 Query: 517 ------------------VKRDLEDLGRLVLYVVKKGSISFEDLK---------AQSNEE 549 K D+ G L+ ++ +G+ + D+ Sbjct: 188 KLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLL 247 Query: 550 VVQLSPDEETKDLIHRLFHPGEHVRDCLSDLL 581 + PD + ++ + +HP +R S+L+ Sbjct: 248 QPEYCPDPLYEVML-KCWHPKAEMRPSFSELV 278 >6BSD-A nrPDB Length = 876 Score = 72.4 bits (176), Expect = 7e-13, Method: Composition-based stats. Identities = 46/258 (17%), Positives = 78/258 (30%), Gaps = 64/258 (24%) Query: 389 VAVKTFCEGSPR-----AQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQT-LE 442 VAVK + + +EV + ++ +++ G L + E L Sbjct: 615 VAVKILRPDATKNARNDFLKEVKIMSRLKD-PNIIRLLGVCVQDDPLCMITDYMENGDLN 673 Query: 443 ACLDVHRGEDVENE--------------EDEFARNVLSSIFKAVQELHLSCGYTHQDLQP 488 L H+ ED E +V + I ++ L + + H+DL Sbjct: 674 QFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL-ATLNFVHRDLAT 732 Query: 489 QNILIDSKKAAHLADFDKSIKW-AGDPQEVK-----------------------RDLEDL 524 +N L+ +ADF S AGD V+ D+ Sbjct: 733 RNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAF 792 Query: 525 GRLVLYVVK-KGSISFEDLK-AQSNEEVVQLSPDEETK--------------DLIHRLFH 568 G + V+ + F L Q E + D+ + +L+ R + Sbjct: 793 GVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWS 852 Query: 569 PGEHVRDCLSDLLGHPFF 586 R S L H F Sbjct: 853 RESEQRPPFSQL--HRFL 868 >3Q4U-A nrPDB Length = 301 Score = 72.0 bits (175), Expect = 8e-13, Method: Composition-based stats. Identities = 40/281 (14%), Positives = 76/281 (27%), Gaps = 70/281 (24%) Query: 371 IADTSEGGIYLGFYEKQEVAVKTFC-EGSPRAQREVSCLQSS-RENSHLVTFYGSESHRG 428 + G ++ G ++ + VAVK F RE + + +++ F S+ Sbjct: 16 VGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSR 75 Query: 429 HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSC-------GY 481 H + L E + + R VL SI + LH+ Sbjct: 76 HSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVL-SIASGLAHLHIEIFGTQGKPAI 134 Query: 482 THQDLQPQNILIDSKKAAHLADFDKSI---------KWAGDP------------------ 514 H+DL+ +NIL+ +AD ++ +P Sbjct: 135 AHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQ 194 Query: 515 -----QEVKRDLEDLGRLV-------------------LYVVKKGSISFEDLKAQSNEE- 549 + D+ G ++ Y V SFED++ + Sbjct: 195 VDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQ 254 Query: 550 --------VVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLG 582 L+ ++ R + Sbjct: 255 QRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK 295 >4L00-A nrPDB Length = 304 Score = 71.7 bits (174), Expect = 1e-12, Method: Composition-based stats. Identities = 36/238 (15%), Positives = 67/238 (28%), Gaps = 43/238 (18%) Query: 385 EKQEVAVKTFCEGSPRAQREVSC-------LQSSRENSHLVTFYGSESHRGHLFVCVTLC 437 +E +K + + R++S + + H+V YG + Sbjct: 55 TSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFV 114 Query: 438 EQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKK 497 E L +HR DV +F V + A+ L H ++ +N+L+ + Sbjct: 115 EGGPL-DLFMHRKSDVLTTPWKF--KVAKQLASALSYL-EDKDLVHGNVCTKNLLLAREG 170 Query: 498 A-------AHLADFDKSIKWAGDPQ-------------------EVKRDLEDLGRLVLYV 531 L+D I + V D G + + Sbjct: 171 IDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEI 230 Query: 532 VKKGSISFEDLKAQSNEE------VVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGH 583 G I +D E +E DL+ R + + R ++ Sbjct: 231 CYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRD 288 >3ZBF-A nrPDB Length = 322 Score = 71.7 bits (174), Expect = 1e-12, Method: Composition-based stats. Identities = 51/327 (15%), Positives = 96/327 (29%), Gaps = 66/327 (20%) Query: 331 PPAEDWKPQSSHWGAALKDLHRI-YRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEV 389 P E+ Q S ++ R ++G F E Y+ G+ G + V Sbjct: 13 PTTENLYFQGSIENLPAFPREKLTLRLLLGSGAF--GEVYEGTAVDILGVGSGEIK---V 67 Query: 390 AVKTFCEGSPRAQREVSCLQSSR-----ENSHLVTFYGSESHRGHLFVCVTLCEQT-LEA 443 AVKT +GS ++ + L+ + + +++ G ++ + L E L Sbjct: 68 AVKTLKKGSTDQEK-IEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLT 126 Query: 444 CLDVHRGEDV--ENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILI-----DSK 496 L R ++ I K L + H+DL +N L+ S Sbjct: 127 YLRKARMATFYGPLLTLVDLVDLCVDISKGCVYL-ERMHFIHRDLAARNCLVSVKDYTSP 185 Query: 497 KAAHLADFDKSIKWAGDPQEVKR------------------------DLEDLGRLVLYVV 532 + + DF + + KR D+ G L+ ++ Sbjct: 186 RIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEIL 245 Query: 533 KKGSISF----------EDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLG 582 G + E D +L+ + + R + Sbjct: 246 TLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDD--LWNLMTQCWAQEPDQRPTFHRI-- 301 Query: 583 HPFFWTWESRYRTLRNVGNESDIKTRK 609 + + + RN S K+R Sbjct: 302 -------QDQLQLFRNFFLNSIYKSRD 321 >3MDY-A nrPDB Length = 337 Score = 71.3 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 29/157 (18%), Positives = 59/157 (37%), Gaps = 10/157 (6%) Query: 370 KIADTSEGGIYLGFYEKQEVAVKTFCEGSPRA-QREVSCLQSSR-ENSHLVTFYGSESHR 427 +I G +++G + ++VAVK F + RE Q+ + +++ F ++ Sbjct: 44 QIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKG 103 Query: 428 GHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSC-------G 480 + + L E + + + + S + LH Sbjct: 104 TGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLK-LAYSSVSGLCHLHTEIFSTQGKPA 162 Query: 481 YTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV 517 H+DL+ +NIL+ +AD ++K+ D EV Sbjct: 163 IAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEV 199 >3G2F-A nrPDB Length = 336 Score = 71.3 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 29/159 (18%), Positives = 59/159 (37%), Gaps = 22/159 (13%) Query: 371 IADTSEGGIYLGFYEKQEVAVKTF-CEGSPRAQREVSCLQS-SRENSHLVTFYGSESH-- 426 I G +Y G +++ VAVK F E + + E+ ++ F + Sbjct: 21 IGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVT 80 Query: 427 ---RGHLFVCVTLCEQT-LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSC--- 479 R + + L L +H + V + + S+ + + LH Sbjct: 81 ADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCR------LAHSVTRGLAYLHTELPRG 134 Query: 480 -----GYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD 513 +H+DL +N+L+ + ++DF S++ G+ Sbjct: 135 DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGN 173 >4KIK-B nrPDB Length = 677 Score = 70.5 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 32/213 (15%), Positives = 70/213 (32%), Gaps = 47/213 (22%) Query: 369 YKIADTSEGGIYLGFYE------KQEVAVKTFCEG-SPRAQR----EVSCLQSSRENSHL 417 +++ + G + +++A+K + SPR + E+ ++ + ++ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLT-HPNV 79 Query: 418 VTFYGS------ESHRGHLFVCVTLCEQT-LEACLDVHRGEDVENEEDEFARNVLSSIFK 470 V + + + C+ L L+ E+ + +LS I Sbjct: 80 VAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQF--ENCCGLREGAILTLLSDIAS 137 Query: 471 AVQELHLSCGYTHQDLQPQNILIDSKKAA---HLADFD---------KSIKWAGDPQE-- 516 A++ LH + H+DL+P+NI++ + + D + G Q Sbjct: 138 ALRYLHEN-RIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLA 196 Query: 517 ----------VKRDLEDLGRLVLYVVKKGSISF 539 V D G + + G F Sbjct: 197 PELLEQQKYTVTVDYWSFG-TLAFECITGFRPF 228 >5TQX-A nrPDB Length = 655 Score = 70.5 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 30/209 (14%), Positives = 68/209 (32%), Gaps = 42/209 (20%) Query: 368 KYKIADTSEGGI--YLGFYEKQEVAVKTFCEGSPRAQRE-----VSCLQSSRENSHLVTF 420 + ++ G + Y ++A+K+ RE + ++ ++++V Sbjct: 13 RERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKL-NHANVVKA 71 Query: 421 YGSESHRGHL-----FVCVTLCEQT-LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 L + + C L L+ + E+ ++ ++LS I ++ Sbjct: 72 CDVPEELNILIHDVPLLAMEYCSGGDLRKLLN--KPENCCGLKESQILSLLSDIGSGIRY 129 Query: 475 LHLSCGYTHQDLQPQNILIDSKKAA---HLADFD---------KSIKWAGD--------- 513 LH + H+DL+P+NI++ + D ++ G Sbjct: 130 LHEN-KIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPELF 188 Query: 514 ---PQEVKRDLEDLGRLVLYVVKKGSISF 539 P D G +++ G F Sbjct: 189 ENKPYTATVDYWSFG-TMVFECIAGYRPF 216 >4TN6-A nrPDB Length = 318 Score = 70.5 bits (171), Expect = 3e-12, Method: Composition-based stats. Identities = 46/247 (18%), Positives = 86/247 (34%), Gaps = 42/247 (17%) Query: 370 KIADTSEGGIYLG--FYEKQEVAVKTFCEGSPRAQR--EVSCLQSSRENSHLVTFYGSES 425 KI S G IYLG +EVA+K C + Q E + + + T + Sbjct: 14 KIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGA 73 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 + + + L +LE + + A + ++ +H S + H+D Sbjct: 74 EGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLA----DQMISRIEYIH-SKNFIHRD 128 Query: 486 LQPQNIL--IDSKKA-AHLADFDKSIKWA-----------------------------GD 513 ++P N L + K ++ DF + K+ G Sbjct: 129 VKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGI 188 Query: 514 PQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHV 573 Q + DLE LG +++Y GS+ ++ LKA + + + +++ I L Sbjct: 189 EQSRRDDLESLGYVLMY-FNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSE 247 Query: 574 RDCLSDL 580 + Sbjct: 248 FATYLNF 254 >4HZS-A nrPDB Length = 341 Score = 70.1 bits (170), Expect = 3e-12, Method: Composition-based stats. Identities = 45/276 (16%), Positives = 88/276 (31%), Gaps = 55/276 (19%) Query: 370 KIADTSEGGIYLGFYEKQE-----VAVKTF-------CEGSPRAQREVSCLQSSRENSHL 417 K+ D S G + G ++ VAVK E REV+ + S ++ +L Sbjct: 19 KLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMH-SLDHRNL 77 Query: 418 VTFYGSESHRGHLFVCVTLCE-QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 + YG + + L +L L H+G + +A + + + L Sbjct: 78 IRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYA----VQVAEGMGYL- 131 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWA------------------GDPQEVK 518 S + H+DL +N+L+ ++ + DF P+ +K Sbjct: 132 ESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLK 191 Query: 519 -------RDLEDLGRLVLYVVKKGSISFEDL-------KAQSNEEVVQLSPD--EETKDL 562 D G + + G + L K E + D ++ ++ Sbjct: 192 TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNV 251 Query: 563 IHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRN 598 + + + R L + R L++ Sbjct: 252 MVQCWAHKPEDRPTFV-ALRDFLLEAQPTDMRALQD 286 >3C1X-A nrPDB Length = 373 Score = 70.1 bits (170), Expect = 3e-12, Method: Composition-based stats. Identities = 43/272 (15%), Positives = 86/272 (31%), Gaps = 54/272 (19%) Query: 357 MIGKLKFFIDEKYKIADTSEGGIYLGFYEKQE-----VAVKTFCEGSPRAQREVS----- 406 +IG + I G +Y G + AVK+ + EVS Sbjct: 83 VIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIG--EVSQFLTE 140 Query: 407 -CLQSSRENSHLVTFYGS-ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNV 464 + + ++++ G G V + + + R E + Sbjct: 141 GIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHG--DLRNFIRNETHNPTVKDLIGFG 198 Query: 465 LSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK--------------- 509 L + K ++ L S + H+DL +N ++D K +ADF + Sbjct: 199 L-QVAKGMKFL-ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGA 256 Query: 510 -----------WAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLK---------AQSNEE 549 K D+ G L+ ++ +G+ + D+ Sbjct: 257 KLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLL 316 Query: 550 VVQLSPDEETKDLIHRLFHPGEHVRDCLSDLL 581 + PD + ++ + +HP +R S+L+ Sbjct: 317 QPEYCPDPLYEVML-KCWHPKAEMRPSFSELV 347 >5IRX-A nrPDB Length = 636 Score = 70.1 bits (170), Expect = 3e-12, Method: Composition-based stats. Identities = 46/203 (22%), Positives = 70/203 (34%), Gaps = 42/203 (20%) Query: 27 HLLIKA---VQNEDVDLVQQLLEGGANVNFQEEE----------GGWTPLHNAVQMSRED 73 L+KA + N D + LL+ + ++ G T LH A++ Sbjct: 51 TCLLKAMLNLHNGQNDTIALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMT 110 Query: 74 IVELLLRHGADPVLRKKN--------------GATPFILAAIAGSVKLLKLFLSK---GA 116 +V LL+ +GAD G P LAA + ++K L A Sbjct: 111 LVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPA 170 Query: 117 DVNECDFYGFTAFM--EAAVYGKVKALKF-------LYKRGANVNLRRKTKEDQERLRKG 167 D++ D G T V KF + GA ++ K +E + Sbjct: 171 DISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEIT---NRK 227 Query: 168 GATALMDAAEKGHVEVLKILLDE 190 G T L AA G + VL +L Sbjct: 228 GLTPLALAASSGKIGVLAYILQR 250 Score = 67.8 bits (164), Expect = 2e-11, Method: Composition-based stats. Identities = 38/159 (23%), Positives = 70/159 (44%), Gaps = 20/159 (12%) Query: 123 FYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKG----GATALMDAAEK 178 + G TA A + + L + GA+V ++ + G L AA Sbjct: 94 YKGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACT 153 Query: 179 GHVEVLKILLDEM--GADVNACDNMGRNALIHALLSSDDSDVEAITHL------LLDHGA 230 + ++K LL AD++A D++G N ++HAL+ D+ V+ + +L GA Sbjct: 154 NQLAIVKFLLQNSWQPADISARDSVG-NTVLHALVEVADNTVDNTKFVTSMYNEILILGA 212 Query: 231 DVN-------VRGERGKTPLILAVEKKHLGLVQRLLEQE 262 ++ + +G TPL LA +G++ +L++E Sbjct: 213 KLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQRE 251 Score = 53.9 bits (128), Expect = 3e-07, Method: Composition-based stats. Identities = 49/260 (18%), Positives = 89/260 (34%), Gaps = 44/260 (16%) Query: 154 RRKTKEDQERLRKGGATALMDA---AEKGHVEVLKILLD------EMGADVNACDNMGRN 204 +++ + + + + G T L+ A G + + +LLD + VNA Sbjct: 35 KKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTIALLLDVARKTDSLKQFVNASYTDSYY 94 Query: 205 ALIHALLSSDDSDVEAITHLLLDHGADVNVRGE--------------RGKTPLILAVEKK 250 AL + + + LL+++GADV G+ PL LA Sbjct: 95 KGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTN 154 Query: 251 HLGLVQRLLEQ--EHIEINDTDSDGKTALLLAVELK--LKKIAELLCKRGASTDCGDLVM 306 L +V+ LL+ + +I+ DS G T L VE+ + + L++ Sbjct: 155 QLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEI----LIL 210 Query: 307 TARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGA-ALKDLHRIYRPMIGKLKFFI 365 A+ + L ++ G S G A I+ P L Sbjct: 211 GAKLHPTLKLEEITNRKGL------TPLALAASSGKIGVLAYILQREIHEPECRHLSR-- 262 Query: 366 DEKYKIADTSEGGIYLGFYE 385 K + + G ++ Y+ Sbjct: 263 ----KFTEWAYGPVHSSLYD 278 >5L2Q-C nrPDB Length = 320 Score = 70.1 bits (170), Expect = 3e-12, Method: Composition-based stats. Identities = 40/237 (16%), Positives = 72/237 (30%), Gaps = 59/237 (24%) Query: 403 REVSCLQSSRENSHLVTFYGSESHRGH----------------LFVCVTL---CEQTL-E 442 E S L +V +G R +C+ L C + Sbjct: 73 TEYSLLSLLHTQDGVVHHHGLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSD 132 Query: 443 ACLDVHRGEDVENEEDEFAR----NVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA 498 D+ + +E + + + + V+ LH H+DL+ N++++ + Sbjct: 133 KTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQK-NIVHRDLKLGNMVLNKRTH 191 Query: 499 -AHLADF----------DKSIKWAGDPQEVK-------------RDLEDLGRLVLYVVKK 534 + +F D G P + D+ LG +VL+ + Sbjct: 192 RITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALG-VVLFTMLY 250 Query: 535 GSISFED-----LKAQSNEEVVQLSPD----EETKDLIHRLFHPGEHVRDCLSDLLG 582 G F D L + + D E T LI +L R +D+L Sbjct: 251 GQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLE 307 >4F9B-A nrPDB Length = 361 Score = 69.7 bits (169), Expect = 4e-12, Method: Composition-based stats. Identities = 56/351 (15%), Positives = 111/351 (31%), Gaps = 87/351 (24%) Query: 347 LKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYE-----KQEVAVKTFCEGSP-- 399 KD+ ++Y + +L + KI + + +YL + ++++A+K S Sbjct: 6 KKDIEKLYEA-VPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPI 64 Query: 400 RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDE 459 R E+ CL + +++ H+ + + E E+ LD+ + + + Sbjct: 65 RIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEH--ESFLDI-----LNSLSFQ 117 Query: 460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK-KAAHLADFDKSIKW-------- 510 R + ++FKA++ +H G H+D++P N L + + K L DF + Sbjct: 118 EVREYMLNLFKALKRIHQ-FGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELL 176 Query: 511 ------------------------------AGDP-------------QEVKRDLEDLGRL 527 AG P Q D+ G + Sbjct: 177 KFVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVI 236 Query: 528 VLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFW 587 L + G F ++ L + G + G Sbjct: 237 FL-SLLSGRYPFYK-------------ASDDLTALAQIMTIRGSRETIQAAKTFGKSILC 282 Query: 588 TWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINE 638 + E + LR + R +S L H+ + + W +E Sbjct: 283 SKEVPAQDLRKLCERL----RGMDSS-TPKLTSDIQGHATNLEGWNEVPDE 328 >2NYJ-A nrPDB Length = 273 Score = 69.7 bits (169), Expect = 4e-12, Method: Composition-based stats. Identities = 46/203 (22%), Positives = 70/203 (34%), Gaps = 42/203 (20%) Query: 27 HLLIKA---VQNEDVDLVQQLLEGGANVNFQEEE----------GGWTPLHNAVQMSRED 73 L+KA + N D + LL+ + ++ G T LH A++ Sbjct: 56 TCLLKAMLNLHNGQNDTIALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMT 115 Query: 74 IVELLLRHGADPVLRKKN--------------GATPFILAAIAGSVKLLKLFLSK---GA 116 +V LL+ +GAD G P LAA + ++K L A Sbjct: 116 LVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPA 175 Query: 117 DVNECDFYGFTAFM--EAAVYGKVKALKF-------LYKRGANVNLRRKTKEDQERLRKG 167 D++ D G T V KF + GA ++ K +E + Sbjct: 176 DISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEIT---NRK 232 Query: 168 GATALMDAAEKGHVEVLKILLDE 190 G T L AA G + VL +L Sbjct: 233 GLTPLALAASSGKIGVLAYILQR 255 Score = 67.4 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 38/159 (23%), Positives = 70/159 (44%), Gaps = 20/159 (12%) Query: 123 FYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKG----GATALMDAAEK 178 + G TA A + + L + GA+V ++ + G L AA Sbjct: 99 YKGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACT 158 Query: 179 GHVEVLKILLDEM--GADVNACDNMGRNALIHALLSSDDSDVEAITHL------LLDHGA 230 + ++K LL AD++A D++G N ++HAL+ D+ V+ + +L GA Sbjct: 159 NQLAIVKFLLQNSWQPADISARDSVG-NTVLHALVEVADNTVDNTKFVTSMYNEILILGA 217 Query: 231 DVN-------VRGERGKTPLILAVEKKHLGLVQRLLEQE 262 ++ + +G TPL LA +G++ +L++E Sbjct: 218 KLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQRE 256 Score = 53.2 bits (126), Expect = 4e-07, Method: Composition-based stats. Identities = 36/156 (23%), Positives = 62/156 (39%), Gaps = 25/156 (16%) Query: 154 RRKTKEDQERLRKGGATALMDA---AEKGHVEVLKILLD------EMGADVNACDNMGRN 204 +++ + + + + G T L+ A G + + +LLD + VNA Sbjct: 40 KKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTIALLLDVARKTDSLKQFVNASYTDSYY 99 Query: 205 ALIHALLSSDDSDVEAITHLLLDHGADVNVRGE--------------RGKTPLILAVEKK 250 AL + + + LL+++GADV G+ PL LA Sbjct: 100 KGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTN 159 Query: 251 HLGLVQRLLEQ--EHIEINDTDSDGKTALLLAVELK 284 L +V+ LL+ + +I+ DS G T L VE+ Sbjct: 160 QLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVA 195 Score = 41.2 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 25/116 (21%), Positives = 46/116 (39%), Gaps = 17/116 (14%) Query: 203 RNALIHALLSSDDSDVEAITHLLLDHG---ADVNVRG-ERGKTPLILA---VEKKHLGLV 255 R ++ A+ S+ ++E++ L D + E GKT L+ A + + Sbjct: 14 RRSIFDAVAQSNCQELESLLPFLQRSKKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTI 73 Query: 256 QRLL----------EQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC 301 LL + + D+ G+TAL +A+E + + LL + GA Sbjct: 74 ALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENGADVQA 129 >5U6C-A nrPDB Length = 315 Score = 69.3 bits (168), Expect = 5e-12, Method: Composition-based stats. Identities = 34/279 (12%), Positives = 84/279 (30%), Gaps = 57/279 (20%) Query: 371 IADTSEGGIYLGFYEKQE-----VAVKTFCEGSPRAQR------EVSCLQSSRENSHLVT 419 + + G + G ++++ VAVKT + + E +C++ + +++ Sbjct: 44 LGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFS-HPNVMR 102 Query: 420 FYGSESHRGHL-----FVCVTLCEQTLEACLDVHRGEDVENEEDEFAR--NVLSSIFKAV 472 G V + + ++ + + + I + Sbjct: 103 LLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGM 162 Query: 473 QELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEV--------------- 517 + L + + H+DL +N ++ +ADF S K Sbjct: 163 EYL-SNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIE 221 Query: 518 ---------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEE------VVQLSPD--EETK 560 K D+ G + + +G + ++ + ++ D +E Sbjct: 222 SLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELY 281 Query: 561 DLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNV 599 ++++ + R S L E +L +V Sbjct: 282 EIMYSCWRTDPLDRPTFSVLR-----LQLEKLLESLPDV 315 >1U54-B nrPDB Length = 291 Score = 69.3 bits (168), Expect = 6e-12, Method: Composition-based stats. Identities = 43/258 (16%), Positives = 83/258 (32%), Gaps = 54/258 (20%) Query: 370 KIADTSEGGIYLGFYEKQE-----VAVKTF-------CEGSPRAQREVSCLQSSRENSHL 417 K+ D S G + G ++ VAVK E REV+ + S ++ +L Sbjct: 25 KLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMH-SLDHRNL 83 Query: 418 VTFYGSESHRGHLFVCVTLCE-QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 476 + YG + + L +L L H+G + +A + + + L Sbjct: 84 IRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYA----VQVAEGMGYL- 137 Query: 477 LSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWA------------------GDPQEVK 518 S + H+DL +N+L+ ++ + DF P+ +K Sbjct: 138 ESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLK 197 Query: 519 -------RDLEDLGRLVLYVVKKGSISFEDL-------KAQSNEEVVQLSPD--EETKDL 562 D G + + G + L K E + D ++ ++ Sbjct: 198 TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNV 257 Query: 563 IHRLFHPGEHVRDCLSDL 580 + + + R L Sbjct: 258 MVQCWAHKPEDRPTFVAL 275 >1PY5-A nrPDB Length = 326 Score = 69.3 bits (168), Expect = 6e-12, Method: Composition-based stats. Identities = 28/148 (18%), Positives = 55/148 (37%), Gaps = 10/148 (6%) Query: 371 IADTSEGGIYLGFYEKQEVAVKTFCEGSPRA-QREVSCLQSS-RENSHLVTFYGSESHRG 428 I G ++ G + +EVAVK F R+ RE Q+ + +++ F +++ Sbjct: 37 IGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDN 96 Query: 429 HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSC-------GY 481 + + L E + + L S + LH+ Sbjct: 97 GTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLAL-STASGLAHLHMEIVGTQGKPAI 155 Query: 482 THQDLQPQNILIDSKKAAHLADFDKSIK 509 H+DL+ +NIL+ +AD +++ Sbjct: 156 AHRDLKSKNILVKKNGTCCIADLGLAVR 183 >2WTK-B nrPDB Length = 373 Score = 69.3 bits (168), Expect = 6e-12, Method: Composition-based stats. Identities = 38/276 (13%), Positives = 74/276 (26%), Gaps = 91/276 (32%) Query: 396 EGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVEN 455 E Q E+ + + ++V + + L+V + D+ ++ Sbjct: 52 EMVTFLQGELHVSKLF-NHPNIVPYRATFIADNELWVVTSFMAYGSAK--DLICTHFMDG 108 Query: 456 EEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLA------------- 502 + +L + KA+ +H GY H+ ++ +ILI +L+ Sbjct: 109 MNELAIAYILQGVLKALDYIHH-MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQ 167 Query: 503 ------DFDKSIKWAGDP-------------QEVKRDLEDLGRLVLYVVKKGSISFEDL- 542 DF K P + K D+ +G + G + F+D+ Sbjct: 168 RQRVVHDFPK-YSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITAC-ELANGHVPFKDMP 225 Query: 543 ------------------KAQSNEEVVQLSPDEETKD----------------------- 561 + E + +SP + Sbjct: 226 ATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHP 285 Query: 562 -----------LIHRLFHPGEHVRDCLSDLLGHPFF 586 + + R S LL H FF Sbjct: 286 YHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFF 321 >4MWI-A nrPDB Length = 294 Score = 69.0 bits (167), Expect = 6e-12, Method: Composition-based stats. Identities = 40/258 (15%), Positives = 79/258 (30%), Gaps = 62/258 (24%) Query: 378 GIYLGFYEKQEVAVKTFCE--------GSPRAQREVSCLQSSRENSHLVTFYGSESHR-- 427 +Y G Y + VA+K F + +E+ ++ E+ +++ +G Sbjct: 39 TLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKF-ESPNILRIFGICIDETV 97 Query: 428 --GHLFVCVTLCE-QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG-YTH 483 + + CE TL LD + + ++ + + LH S H Sbjct: 98 TPPQFSIVMEYCELGTLRELLDREKDLTLGKRM-----VLVLGAARGLYRLHHSEAPELH 152 Query: 484 QDLQPQNILIDSKKAAHLADFDKSIKWAGD----------------------------PQ 515 ++ N L+ LA F+ Sbjct: 153 GKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQY 212 Query: 516 EVKRDLEDLGRLVLYVVKKGSISFE-----------DLKAQSNEEVVQLSPDEETKDLIH 564 +VK ++ G +VL+ + G I F+ +K Q E +++I Sbjct: 213 DVKSEIYSFG-IVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCP--SELREIID 269 Query: 565 RLFHPGEHVRDCLSDLLG 582 VR + ++L Sbjct: 270 ECRAHDPSVRPSVDEILK 287 >4Y12-A nrPDB Length = 375 Score = 69.0 bits (167), Expect = 7e-12, Method: Composition-based stats. Identities = 32/192 (16%), Positives = 61/192 (31%), Gaps = 34/192 (17%) Query: 414 NSHLVTFYGSESH-----RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 + +V + H ++ + L +G+ + E A L I Sbjct: 177 HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGG---QSLKRSKGQKLPVAE---AIAYLLEI 230 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK------WAGDPQ------- 515 A+ LH S G + DL+P+NI++ + L D + G P Sbjct: 231 LPALSYLH-SIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLYGTPGFQAPEIV 288 Query: 516 ----EVKRDLEDLGRLVLYVVKKGSISFEDLKAQSN--EEVVQLSPDEETKDLIHRLFHP 569 V D+ +GR + + + + E+ L + L+ R P Sbjct: 289 RTGPTVATDIYTVGRTL--AALTLDLPTRNGRYVDGLPEDDPVLKTYDSYGRLLRRAIDP 346 Query: 570 GEHVRDCLSDLL 581 R ++ + Sbjct: 347 DPRQRFTTAEEM 358 >2PZI-A nrPDB Length = 681 Score = 69.0 bits (167), Expect = 7e-12, Method: Composition-based stats. Identities = 32/192 (16%), Positives = 61/192 (31%), Gaps = 34/192 (17%) Query: 414 NSHLVTFYGSESH-----RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 + +V + H ++ + L +G+ + E A L I Sbjct: 138 HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGG---QSLKRSKGQKLPVAE---AIAYLLEI 191 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK------WAGDPQ------- 515 A+ LH S G + DL+P+NI++ + L D + G P Sbjct: 192 LPALSYLH-SIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLYGTPGFQAPEIV 249 Query: 516 ----EVKRDLEDLGRLVLYVVKKGSISFEDLKAQSN--EEVVQLSPDEETKDLIHRLFHP 569 V D+ +GR + + + + E+ L + L+ R P Sbjct: 250 RTGPTVATDIYTVGRTL--AALTLDLPTRNGRYVDGLPEDDPVLKTYDSYGRLLRRAIDP 307 Query: 570 GEHVRDCLSDLL 581 R ++ + Sbjct: 308 DPRQRFTTAEEM 319 >4M66-A nrPDB Length = 325 Score = 69.0 bits (167), Expect = 7e-12, Method: Composition-based stats. Identities = 39/174 (22%), Positives = 62/174 (35%), Gaps = 22/174 (12%) Query: 343 WGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYE--KQEVAVKTFCEGSPR 400 W + + R + KL+F + G ++ + +VAVK S + Sbjct: 7 WPTGASAVPLVSREELKKLEF-------VGKGGFGVVFRAHHRTWNHDVAVKIV--NSKK 57 Query: 401 AQREVSCLQSSRENSHLVTFYGSESHRGHLFV-----CVTLCEQTLEACLDVHRGEDVEN 455 EV + + R N +++ G FV E A L + Sbjct: 58 ISWEVKAMVNLR-NENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLL----QPEAP 112 Query: 456 EEDEFARNVLSSIFKAVQELH-LSCGYTHQDLQPQNILIDSKKAAHLADFDKSI 508 +L + + LH L H+DL+P NIL+D + A LADF S Sbjct: 113 RPWPLLCRLLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLST 166 >2H34-A nrPDB Length = 309 Score = 68.6 bits (166), Expect = 8e-12, Method: Composition-based stats. Identities = 49/252 (19%), Positives = 82/252 (32%), Gaps = 53/252 (21%) Query: 369 YKIADTSEGGIYLGFYEKQE------VAVKTFCEGSP-------RAQREVSCLQSSRENS 415 Y++ G YE ++ VA+K E R QRE +E Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQE-P 94 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 475 H+V + G L+V + L A + +G A ++ I A+ Sbjct: 95 HVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPR----AVAIVRQIGSALDAA 150 Query: 476 HLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWA-----------GDPQEV------- 517 + G TH+D++P+NIL+ + A+L DF + G + Sbjct: 151 -HAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSE 209 Query: 518 -----KRDLEDLGRLVLYVVKKGSISFEDLK--------AQSNEEVVQLSPD--EETKDL 562 + D+ L VLY GS ++ + Q+ + P + Sbjct: 210 SHATYRADIYAL-TCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAV 268 Query: 563 IHRLFHPGEHVR 574 I R R Sbjct: 269 IARGMAKNPEDR 280 >3UIM-A nrPDB Length = 326 Score = 68.2 bits (165), Expect = 1e-11, Method: Composition-based stats. Identities = 50/275 (18%), Positives = 86/275 (31%), Gaps = 61/275 (22%) Query: 366 DEKYKIADTSEGGIYLGFY-EKQEVAVKTFCEGSPR-----AQREVSCLQSSRENSHLVT 419 K + G +Y G + VAVK E + Q EV + S + +L+ Sbjct: 33 SNKNILGRGGFGKVYKGRLADGTLVAVKRLKEERTQGGELQFQTEVEMI-SMAVHRNLLR 91 Query: 420 FYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSC 479 G + A R E + + + + + LH C Sbjct: 92 LRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHC 151 Query: 480 --GYTHQDLQPQNILIDSKKAAHLADFDKSI-----------KWAGD-----PQEV---- 517 H+D++ NIL+D + A + DF + G P+ + Sbjct: 152 DPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGK 211 Query: 518 ---KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSP------------------- 555 K D+ G ++L + G +F DL +N++ V L Sbjct: 212 SSEKTDVFGYG-VMLLELITGQRAF-DLARLANDDDVMLLDWVKGLLKEKKLEALVDVDL 269 Query: 556 -----DEETKDLIH---RLFHPGEHVRDCLSDLLG 582 DEE + LI R +S+++ Sbjct: 270 QGNYKDEEVEQLIQVALLCTQSSPMERPKMSEVVR 304 >5UNP-A nrPDB Length = 369 Score = 67.8 bits (164), Expect = 2e-11, Method: Composition-based stats. Identities = 51/334 (15%), Positives = 96/334 (28%), Gaps = 109/334 (32%) Query: 357 MIGKLKFFIDEKYKIADTSEGGIYLGFYE-------KQEVAVKTFCEGSPR---AQREVS 406 +I + ++ E+Y+I T G + + VA+K A+ E++ Sbjct: 24 LIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEIN 83 Query: 407 CLQSSR----ENSHL-VTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFA 461 L+ +N +L V + + GH+ + L + D + + Sbjct: 84 VLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLST---FDFLKDNNYLPYPIHQV 140 Query: 462 RNVLSSIFKAVQELHLSCGYTHQDLQPQNILID-------------------SKKAAHLA 502 R++ + +AV+ LH + TH DL+P+NIL A + Sbjct: 141 RHMAFQLCQAVKFLHDN-KLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVV 199 Query: 503 DFDKSI-------KWAGDPQEVK------------RDLEDLGRLVLYVVKKGSISFED-- 541 DF + D+ +G ++ + G F+ Sbjct: 200 DFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCII-FEYYVGFTLFQTHD 258 Query: 542 -------------------------------------------LKAQSNEEVVQLSPDEE 558 + N + ++ E Sbjct: 259 NREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSE 318 Query: 559 TK------DLIHRLFHPGEHVRDCLSDLLGHPFF 586 + DLI + R L + L HPFF Sbjct: 319 AEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF 352 >3LMG-A nrPDB Length = 344 Score = 67.4 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 48/300 (16%), Positives = 92/300 (30%), Gaps = 64/300 (21%) Query: 370 KIADTSEGGIYLGFYEKQ------EVAVKTFCEGSPR----AQREVSCLQSSRENSHLVT 419 + G ++ G + + V +K + S R A + S +++H+V Sbjct: 38 VLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVR 97 Query: 420 FYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSC 479 G L + L H + + N I K + L Sbjct: 98 LLG-LCPGSSLQLVTQYLPLGS---LLDHVRQHRGALGPQLLLNWGVQIAKGMYYL-EEH 152 Query: 480 GYTHQDLQPQNILIDSKKAAHLADFDKS------------------IKWAG------DPQ 515 G H++L +N+L+ S +ADF + IKW Sbjct: 153 GMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKY 212 Query: 516 EVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQ----------LSPDEETKDLIHR 565 + D+ G V ++ G+ + L+ ++++ + D ++ + Sbjct: 213 THQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTID--VYMVMVK 270 Query: 566 LFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEH 625 + E++R + L + F R L IK + PGP H Sbjct: 271 CWMIDENIRPTFKE-LANEFTRMARDPPRYLV-------IKRESGPG-----IAPGPEPH 317 >5WNL-A nrPDB Length = 342 Score = 67.4 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 42/280 (15%), Positives = 88/280 (31%), Gaps = 62/280 (22%) Query: 355 RPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEV------AVKTFCEGSPRAQREVSCL 408 R +G L+ F ++ + G + Y+ + V A+K + + L Sbjct: 8 RWALGLLRTFDAGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELL 67 Query: 409 QSSREN-----SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARN 463 + +++ +++ YG + + + E L D R Sbjct: 68 EEAKKMEMAKFRYILPVYGICQEP--VGLVMEYMETGSLEKLLASE----PLPWDLRFR- 120 Query: 464 VLSSIFKAVQELH-LSCGYTHQDLQPQNILIDSKKAAHLADFDKSI--------KWAGD- 513 ++ + LH +S H +L+P NIL+D+ ++DF + + D Sbjct: 121 IVHETAVGMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDG 180 Query: 514 ---------PQEVKR---------DLEDLGRLVLYVVKKGSISFEDLKA-------QSNE 548 P+ ++ D+ ++ V+ + F D K Sbjct: 181 LFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQ-KKPFADEKNILHIMMKVVKG 239 Query: 549 EVVQLSP--------DEETKDLIHRLFHPGEHVRDCLSDL 580 +L P L+ R +H VR ++ Sbjct: 240 HRPELPPICRPRPRACASLIGLMQRCWHADPQVRPTFQEI 279 >4RT7-A nrPDB Length = 415 Score = 67.4 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 34/219 (15%), Positives = 61/219 (27%), Gaps = 45/219 (20%) Query: 395 CEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVE 454 S REV S + + +G+ H E + L+ +V Sbjct: 190 PNSSMPGSREVQIHPDSDQ---ISGLHGNSFHSEDE------IEYENQKRLEEEEDLNVL 240 Query: 455 NEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDP 514 ED + K ++ L H+DL +N+L+ K + DF + D Sbjct: 241 TFEDLLC--FAYQVAKGMEFLEFK-SCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDS 297 Query: 515 QEV------------------------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEV 550 V K D+ G L+ + G + + +N Sbjct: 298 NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYK 357 Query: 551 V---------QLSPDEETKDLIHRLFHPGEHVRDCLSDL 580 + EE ++ + R +L Sbjct: 358 LIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 396 Score = 37.8 bits (86), Expect = 0.019, Method: Composition-based stats. Identities = 14/91 (15%), Positives = 30/91 (32%), Gaps = 16/91 (17%) Query: 363 FFIDEKYKIADTSEGGIYLGFYEKQ-----------EVAVKTFCEGSPRAQRE-----VS 406 F E + G + +VAVK E + ++RE + Sbjct: 61 EFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELK 120 Query: 407 CLQSSRENSHLVTFYGSESHRGHLFVCVTLC 437 + + ++V G+ + G +++ C Sbjct: 121 MMTQLGSHENIVNLLGACTLSGPIYLIFEYC 151 >4M69-B nrPDB Length = 283 Score = 67.4 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 43/265 (16%), Positives = 88/265 (33%), Gaps = 62/265 (23%) Query: 370 KIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQR----------EVSCLQSSRENSHLVT 419 K+ + IY G Y + V +K F P+A+ E+ ++ ++ +++ Sbjct: 16 KLKTSKMSTIYRGEYHRSPVTIKVFNN--PQAESVGIVRFTFNDEIKTMKKF-DSPNILR 72 Query: 420 FYGSESHR----GHLFVCVTLCE-QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 +G + + + CE TL LD + + R + + Sbjct: 73 IFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRA-----ARGLYR 127 Query: 475 LHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAG---------------------- 512 LH S H+++ + L+ LA F+ S Sbjct: 128 LHHSET-LHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPE 186 Query: 513 ---DP---QEVKRDLEDLGRLVLYVVKKGSISFE-----DLKAQSNEEVVQLSPD----E 557 +P ++K ++ G +VL+ + G I FE ++ E+ Q E Sbjct: 187 RLKNPFCLYDIKAEIYSFG-IVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPE 245 Query: 558 ETKDLIHRLFHPGEHVRDCLSDLLG 582 +++I+ R + +L Sbjct: 246 LLREIINECRAHEPSQRPSVDGILE 270 >3MY0-A nrPDB Length = 305 Score = 67.0 bits (162), Expect = 3e-11, Method: Composition-based stats. Identities = 44/307 (14%), Positives = 87/307 (28%), Gaps = 90/307 (29%) Query: 371 IADTSEGGIYLGFYEKQEVAVKTFC-EGSPRAQREVSCLQSSR-ENSHLVTFYGSESHR- 427 + G ++ G + + VAVK F RE + + +++ F S+ Sbjct: 16 VGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSR 75 Query: 428 ---GHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSC----- 479 L++ E + D + + + E A + S + LH+ Sbjct: 76 NSSTQLWLITHYHEHG--SLYDFLQRQTL---EPHLALRLAVSAACGLAHLHVEIFGTQG 130 Query: 480 --GYTHQDLQPQNILIDSKKAAHLADFDKSI---------KWAGDP-------------- 514 H+D + +N+L+ S +AD ++ +P Sbjct: 131 KPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLD 190 Query: 515 ---------QEVKRDLEDLGRLV-------------------LYVVKKGSISFEDLKAQS 546 D+ G ++ Y V SFED+K Sbjct: 191 EQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVV 250 Query: 547 NEE------VVQLSPDEETKDL---IHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLR 597 + +L+ D L + ++P R + TL+ Sbjct: 251 CVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKK------------TLQ 298 Query: 598 NVGNESD 604 + N + Sbjct: 299 KISNSPE 305 >4BTF-A nrPDB Length = 469 Score = 67.0 bits (162), Expect = 3e-11, Method: Composition-based stats. Identities = 43/265 (16%), Positives = 88/265 (33%), Gaps = 62/265 (23%) Query: 370 KIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQR----------EVSCLQSSRENSHLVT 419 K+ + IY G Y + V +K F P+A+ E+ ++ ++ +++ Sbjct: 202 KLKTSKMSTIYRGEYHRSPVTIKVFNN--PQAESVGIVRFTFNDEIKTMKKF-DSPNILR 258 Query: 420 FYGSESHR----GHLFVCVTLCE-QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 +G + + + CE TL LD + + R + + Sbjct: 259 IFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRA-----ARGLYR 313 Query: 475 LHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAG---------------------- 512 LH S H+++ + L+ LA F+ S Sbjct: 314 LHHSET-LHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPE 372 Query: 513 ---DP---QEVKRDLEDLGRLVLYVVKKGSISFE-----DLKAQSNEEVVQLSPD----E 557 +P ++K ++ G +VL+ + G I FE ++ E+ Q E Sbjct: 373 RLKNPFCLYDIKAEIYSFG-IVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPE 431 Query: 558 ETKDLIHRLFHPGEHVRDCLSDLLG 582 +++I+ R + +L Sbjct: 432 LLREIINECRAHEPSQRPSVDGILE 456 >5AR8-A nrPDB Length = 326 Score = 66.6 bits (161), Expect = 3e-11, Method: Composition-based stats. Identities = 49/267 (18%), Positives = 79/267 (29%), Gaps = 62/267 (23%) Query: 388 EVAVKTFCEGSPR-------AQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQT 440 +VAVK +P RE L +R S+++ G + L + Sbjct: 59 QVAVKHLHIHTPLLDSERKDVLREAEILHKARF-SYILPILGICNEPEFLGIVTEYMPNG 117 Query: 441 LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH-LSCGYTHQDLQPQNILIDSKKAA 499 L +HR + + +L I V LH ++ H DL+ QNIL+D++ Sbjct: 118 SLNEL-LHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHV 176 Query: 500 HLADFDKSI----------KWAGDPQ--------------------EVKRDLEDLGRLVL 529 +ADF S P+ +K D+ ++ Sbjct: 177 KIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSY-AVIT 235 Query: 530 YVVKKGSISFEDLKA--------------QSNEEVVQLSPDEETKD--LIHRLFHPGEHV 573 + V FED+ NEE + + LI + Sbjct: 236 WEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDE 295 Query: 574 RDCLSDLLGHPFFWTWESRYRTLRNVG 600 R L E RT + Sbjct: 296 RPSFLKCL-----IELEPVLRTFEEIT 317 >6MHW-A nrPDB Length = 826 Score = 66.6 bits (161), Expect = 4e-11, Method: Composition-based stats. Identities = 41/199 (20%), Positives = 77/199 (38%), Gaps = 26/199 (13%) Query: 90 KNGATPFILA---AIAGSVKLLKLFLSK-----------GADVNECDFYGFTAFMEAAVY 135 G T + A + +++++ L+ A+ E + G TA A Sbjct: 167 DTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIER 226 Query: 136 GKVKALKFLYKRGANVNLRRK----TKEDQERLRKGGATALMDAAEKGHVEVLKILLDEM 191 + L GA+VN K + Q G T L AA E++++L++ Sbjct: 227 RQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHE 286 Query: 192 GADVNACDNMGRNALIHALLSSDDSD-----VEAITHLLLDHGADV---NVRGERGKTPL 243 D+ + D+ G N L + ++D V+ + ++L + R G TPL Sbjct: 287 QTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPL 346 Query: 244 ILAVEKKHLGLVQRLLEQE 262 LA + +++ +L +E Sbjct: 347 QLAAKMGKAEILKYILSRE 365 Score = 44.3 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 37/139 (26%), Positives = 52/139 (37%), Gaps = 23/139 (16%) Query: 166 KGGATALMDAAEKGHV---EVLKILLDE------MGADVNACDNM----GRNALIHALLS 212 G T LM A + E+++ILL +G +NA G+ AL A+ Sbjct: 167 DTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIER 226 Query: 213 SDDSDVEAITHLLLD-----HGADVNVRGER-----GKTPLILAVEKKHLGLVQRLLEQE 262 + D GA N + + G+TPL LA +VQ L+E E Sbjct: 227 RQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHE 286 Query: 263 HIEINDTDSDGKTALLLAV 281 +I DS G L V Sbjct: 287 QTDITSRDSRGNNILHALV 305 >5X18-A nrPDB Length = 295 Score = 66.3 bits (160), Expect = 4e-11, Method: Composition-based stats. Identities = 40/219 (18%), Positives = 77/219 (35%), Gaps = 44/219 (20%) Query: 370 KIADTSEGGIYLG--FYEKQEVAVKTFCE--GSPRAQREVSCLQSSRENSHLVTFYGSES 425 KI + S G ++ G VA+K +P+ + E + ++ Y Sbjct: 14 KIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPNIPYAYYFGQ 73 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 H + + L +LE D + + V + +++LH + ++D Sbjct: 74 EGLHNILVIDLLGPSLEDLFDWCGRK----FSVKTVVQVAVQMITLIEDLH-AHDLIYRD 128 Query: 486 LQPQNILIDSKK-----AAHLADFDKSIKWA----------------------------- 511 ++P N LI HL DF + ++ Sbjct: 129 IKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINTHL 188 Query: 512 GDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEV 550 G Q + D+E LG + Y +G + ++ LKA +N++ Sbjct: 189 GREQSRRDDMEALGHVFFY-FLRGHLPWQGLKAPNNKQK 226 >1DCQ-A nrPDB Length = 278 Score = 66.3 bits (160), Expect = 4e-11, Method: Composition-based stats. Identities = 27/134 (20%), Positives = 48/134 (35%), Gaps = 8/134 (5%) Query: 22 AVEDNHLLIKAVQNEDVDLVQQLLEGGAN-----VNFQEEEGGWTPLHNAVQM---SRED 73 H L +AV+ D+ + Q G + E T LH AV+ + Sbjct: 127 TAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLH 186 Query: 74 IVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAA 133 IV+ L+++ + + G+T + + + LKL L A + + G T A Sbjct: 187 IVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAK 246 Query: 134 VYGKVKALKFLYKR 147 + L + Sbjct: 247 RLKHEHCEELLTQA 260 Score = 55.9 bits (133), Expect = 6e-08, Method: Composition-based stats. Identities = 31/201 (15%), Positives = 65/201 (32%), Gaps = 26/201 (12%) Query: 1 MESRDHNNPQEGPTSSSGRRAAV-EDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGG 59 + S D P P S R ++ + + + D +L V ++ G Sbjct: 89 LPSEDPVKPN--PGSDMIARKDYITAKYMERRYARKKHADTAAKLHSLCEAVKTRDIFGL 146 Query: 60 WTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIA---GSVKLLKLFLSKGA 116 D+ E + A+ + T LA + S+ ++ + Sbjct: 147 -----LQAYADGVDLTEKIPL--ANGHEPDE---TALHLAVRSVDRTSLHIVDFLVQNSG 196 Query: 117 DVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAA 176 ++++ G TA + + LK L + A++ + ++ G T L A Sbjct: 197 NLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANES----------GETPLDIAK 246 Query: 177 EKGHVEVLKILLDEMGADVNA 197 H ++L + N+ Sbjct: 247 RLKHEHCEELLTQALSGRFNS 267 Score = 52.8 bits (125), Expect = 6e-07, Method: Composition-based stats. Identities = 31/152 (20%), Positives = 52/152 (34%), Gaps = 12/152 (7%) Query: 119 NECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEK 178 + + EA + L Y G ++ + E TAL A Sbjct: 124 HADTAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDE----TALHLAVRS 179 Query: 179 ---GHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVR 235 + ++ L+ G +++ G AL + L+ D LLL A + + Sbjct: 180 VDRTSLHIVDFLVQNSG-NLDKQTGKGSTALHYCCLT----DNAECLKLLLRGKASIEIA 234 Query: 236 GERGKTPLILAVEKKHLGLVQRLLEQEHIEIN 267 E G+TPL +A KH + L + N Sbjct: 235 NESGETPLDIAKRLKHEHCEELLTQALSGRFN 266 Score = 43.5 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 36/188 (19%), Positives = 61/188 (32%), Gaps = 28/188 (14%) Query: 148 GANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALI 207 G+++ R+ + R+ A K H + L A V D G Sbjct: 100 GSDMIARKDYITAKYMERRY--------ARKKHADTAAKLHSLCEA-VKTRDIFG----- 145 Query: 208 HALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEK-KHLGL-VQRLLEQEHIE 265 LL + V+ + L +G + + +T L LAV L + L Q Sbjct: 146 --LLQAYADGVDLTEKIPLANGHEPD------ETALHLAVRSVDRTSLHIVDFLVQNSGN 197 Query: 266 INDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRN----YDHSLVKVLL 321 ++ G TAL + +LL + AS + + + H + LL Sbjct: 198 LDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEELL 257 Query: 322 SHGAKEDF 329 + F Sbjct: 258 TQALSGRF 265 >5XD6-A nrPDB Length = 305 Score = 66.3 bits (160), Expect = 5e-11, Method: Composition-based stats. Identities = 38/238 (15%), Positives = 76/238 (31%), Gaps = 41/238 (17%) Query: 368 KYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQRE----VSCLQSSRENSHLVTFYGS 423 K I + S G ++ G + + A + S + +E VS + R+ ++V G Sbjct: 27 KSLIGEGSYGRVFYGILKSGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQ-ENVVALLGY 85 Query: 424 ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFK-------AVQELH 476 + + D+ G K ++ LH Sbjct: 86 CVDGPLRVLAYEYAPNG--SLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYLH 143 Query: 477 LSCG--YTHQDLQPQNILIDSKKAAHLADFDK------------SIKWAGD-----PQE- 516 H+D++ N+L+ A +ADFD S + G P+ Sbjct: 144 EKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGYHAPEYA 203 Query: 517 ------VKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFH 568 K D+ G ++L + G + + + VV + + ++D + + Sbjct: 204 MTGTLSTKSDVYSFGVVLL-ELLTGRKPVDHTLPRGQQSVVTWATPKLSEDKVKQCVD 260 >2CHL-A nrPDB Length = 351 Score = 64.7 bits (156), Expect = 2e-10, Method: Composition-based stats. Identities = 42/283 (14%), Positives = 87/283 (30%), Gaps = 68/283 (24%) Query: 363 FFIDEKYKIADTSEGGIY------LGFYEKQEVAVKT--FCEGSPRAQREVSCLQSSREN 414 + +++ G + Y + VA+K +P+ E + Sbjct: 26 LMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSG 85 Query: 415 SHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 + Y + + + L +LE D+ + + + ++ Sbjct: 86 DGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLC----DRTFSLKTVLMIAIQLISRMEY 141 Query: 475 LHLSCGYTHQDLQPQNILIDSKKA-----AHLADFDKSIKWA------------------ 511 +H S ++D++P+N LI H+ DF + ++ Sbjct: 142 VH-SKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTG 200 Query: 512 -----------GDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETK 560 G Q + DLE LG + +Y +GS+ ++ LKA + +E Q Sbjct: 201 TARYMSINTHLGKEQSRRDDLEALGHMFMY-FLRGSLPWQGLKADTLKERYQ-------- 251 Query: 561 DLIHRLFHPGEHVRDCLSDLLGHPF-----FWTWESRYRTLRN 598 G+ R ++L F + + R Sbjct: 252 -------KIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEK 287 >3W9G-A nrPDB Length = 260 Score = 64.3 bits (155), Expect = 2e-10, Method: Composition-based stats. Identities = 36/162 (22%), Positives = 56/162 (34%), Gaps = 29/162 (17%) Query: 59 GWTPLHNAVQMSREDIVELLLRHGADPVLRKKN--------------GATPFILAAIAGS 104 G T LH A++ + VELL+ GAD + + G P LAA Sbjct: 93 GQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQ 152 Query: 105 VKLLKLFLSKG---ADVNECDFYGFTAFM-EAAVYGK--------VKALKFLYKRGANVN 152 ++ G AD+ D G T A+ K L + A + Sbjct: 153 PHIVHYLTENGHKQADLRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLIKCAKLF 212 Query: 153 LRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGAD 194 + L G + LM AA+ G + + + ++ AD Sbjct: 213 P---DTNLEALLNNDGLSPLMMAAKTGKIGIFQHIIRREIAD 251 Score = 50.5 bits (119), Expect = 3e-06, Method: Composition-based stats. Identities = 38/183 (20%), Positives = 61/183 (33%), Gaps = 33/183 (18%) Query: 127 TAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAA---EKGHVEV 183 + G L+ L + +++ +++ R G T L A G + Sbjct: 7 PILFDIVSRGSPDGLEGLLSF--LLTHKKRLTDEEFREPSTGKTCLPKALLNLSAGRNDT 64 Query: 184 LKILLD------EMGADVN--ACDNMGR-NALIHALLSSDDSDVEAITHLLLDHGADVNV 234 + ILLD M +N D R +H + LL++ GADV+ Sbjct: 65 IPILLDIAEKTGNMREFINSPFRDVYYRGQTALHIAIERRCKHY---VELLVEKGADVHA 121 Query: 235 RGE--------------RGKTPLILAVEKKHLGLVQRLLE--QEHIEINDTDSDGKTALL 278 + G+ PL LA +V L E + ++ DS G T L Sbjct: 122 QARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVHYLTENGHKQADLRRQDSRGNTVLH 181 Query: 279 LAV 281 V Sbjct: 182 ALV 184 Score = 37.8 bits (86), Expect = 0.020, Method: Composition-based stats. Identities = 12/30 (40%), Positives = 18/30 (60%) Query: 273 GKTALLLAVELKLKKIAELLCKRGASTDCG 302 G+TAL +A+E + K ELL ++GA Sbjct: 93 GQTALHIAIERRCKHYVELLVEKGADVHAQ 122 >5M07-A nrPDB Length = 276 Score = 64.3 bits (155), Expect = 2e-10, Method: Composition-based stats. Identities = 35/200 (17%), Positives = 69/200 (34%), Gaps = 20/200 (10%) Query: 390 AVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHR 449 A+ E R QRE + H++ + G L++ + + R Sbjct: 66 AMAADDEFRRRFQRETEVAARLF-HPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADR 124 Query: 450 GEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA----AHLADFD 505 V + A +++++ A+ H G H+D+ P N+++ S+ A LADF Sbjct: 125 FPAVLPVGEVLA--IVTAVAGALDYAHQ-RGLLHRDVNPANVVLTSQSAGDQRILLADFG 181 Query: 506 KSIKW--------AGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEV--VQLSP 555 + + AG + + D L ++ + G+ + + P Sbjct: 182 IASQPSYPAPELSAGADVDGRADQYALALTAIH-LFAGAPPVDRSHTGPLQPPKLSAFRP 240 Query: 556 DEETKD-LIHRLFHPGEHVR 574 D D ++ R R Sbjct: 241 DLARLDGVLSRALATAPADR 260 >2C47-A nrPDB Length = 313 Score = 63.6 bits (153), Expect = 3e-10, Method: Composition-based stats. Identities = 47/294 (15%), Positives = 94/294 (31%), Gaps = 68/294 (23%) Query: 367 EKYKIADTSEGGIY------LGFYEKQEVAVKT--FCEGSPRAQREVSCLQSSRENSHLV 418 +++ G + Y + VA+K +P+ E + + Sbjct: 4 PNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVP 63 Query: 419 TFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLS 478 Y + + + L +LE D+ + + + ++ +H Sbjct: 64 QVYYFGPCGKYNAMVLELLGPSLEDLFDLC----DRTFTLKTVLMIAIQLITRMEYVHTK 119 Query: 479 CGYTHQDLQPQNILIDSKK-----AAHLADFDKSIKWA---------------------- 511 ++D++P+N L+ A H+ DF + ++ Sbjct: 120 -SLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 178 Query: 512 -------GDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIH 564 G Q + DLE LG + +Y +GS+ ++ LKA + +E Q Sbjct: 179 MSINTHLGKEQSRRDDLEALGHMFMY-FLRGSLPWQGLKADTLKERYQ------------ 225 Query: 565 RLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLL 618 G+ R ++L F + R +R D K + + LR L Sbjct: 226 ---KIGDTKRATPIEVLCENFPEEMATYLRYVR----RLDF-FEKPDYDYLRKL 271 >5U0K-A nrPDB Length = 141 Score = 63.2 bits (152), Expect = 4e-10, Method: Composition-based stats. Identities = 17/84 (20%), Positives = 37/84 (44%), Gaps = 2/84 (2%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRH-GADPVL 87 L+ A + DV +++ ++ Q++ T LH A ++V+ L+ +P Sbjct: 29 LLFAAYSGDVSALRRFALSAMDME-QKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFA 87 Query: 88 RKKNGATPFILAAIAGSVKLLKLF 111 + + G P A ++++KL Sbjct: 88 KDRWGNIPLDDAVQFNHLEVVKLL 111 Score = 61.3 bits (147), Expect = 2e-09, Method: Composition-based stats. Identities = 26/92 (28%), Positives = 42/92 (45%), Gaps = 9/92 (9%) Query: 96 FILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR 155 + AA +G V L+ F D+ + D+ TA AA G ++ +KFL + Sbjct: 29 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEAC------- 81 Query: 156 KTKEDQERLRKGGATALMDAAEKGHVEVLKIL 187 K + + G L DA + H+EV+K+L Sbjct: 82 --KVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 111 Score = 60.5 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 15/86 (17%), Positives = 31/86 (36%), Gaps = 3/86 (3%) Query: 63 LHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVN--E 120 L A + D + + T +AA G ++++K + + VN Sbjct: 29 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLI-EACKVNPFA 87 Query: 121 CDFYGFTAFMEAAVYGKVKALKFLYK 146 D +G +A + ++ +K L Sbjct: 88 KDRWGNIPLDDAVQFNHLEVVKLLQD 113 Score = 57.0 bits (136), Expect = 3e-08, Method: Composition-based stats. Identities = 20/92 (21%), Positives = 40/92 (43%), Gaps = 1/92 (1%) Query: 201 MGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLE 260 +++ L ++ DV A+ L D+ + +T L +A + H+ +V+ L+E Sbjct: 21 QSMKTVVNLLFAAYSGDVSALRRFALSA-MDMEQKDYDSRTALHVAAAEGHIEVVKFLIE 79 Query: 261 QEHIEINDTDSDGKTALLLAVELKLKKIAELL 292 + D G L AV+ ++ +LL Sbjct: 80 ACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 111 Score = 49.3 bits (116), Expect = 6e-06, Method: Composition-based stats. Identities = 15/60 (25%), Positives = 29/60 (48%) Query: 19 RRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELL 78 + + L A +++V+ L+E F ++ G PL +AVQ + ++V+LL Sbjct: 52 EQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 111 Score = 43.2 bits (100), Expect = 4e-04, Method: Composition-based stats. Identities = 25/100 (25%), Positives = 40/100 (40%), Gaps = 14/100 (14%) Query: 129 FMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188 + AA G V AL+ ++ + TAL AA +GH+EV+K L+ Sbjct: 29 LLFAAYSGDVSALRRFALSAMDMEQKDYDSR----------TALHVAAAEGHIEVVKFLI 78 Query: 189 DEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDH 228 + + A D G L A+ + + LL D+ Sbjct: 79 EACKVNPFAKDRWGNIPLDDAVQFNHLE----VVKLLQDY 114 Score = 33.1 bits (74), Expect = 0.44, Method: Composition-based stats. Identities = 10/53 (18%), Positives = 23/53 (43%), Gaps = 1/53 (1%) Query: 243 LILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKR 295 L+ A + ++R +++ D D +TAL +A ++ + L + Sbjct: 29 LLFAAYSGDVSALRRF-ALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEA 80 >4XD0-A nrPDB Length = 417 Score = 62.8 bits (151), Expect = 5e-10, Method: Composition-based stats. Identities = 22/97 (22%), Positives = 44/97 (45%), Gaps = 4/97 (4%) Query: 66 AVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYG 125 A + + + LL+ + G +P I+AA G++ +++ +SKG ++N+ ++ G Sbjct: 298 ACEDKSPEFISKLLKTENILFEKNHLGWSPIIIAAYHGNMDVIEWLVSKGVNINDRNYKG 357 Query: 126 FTAFMEAAVY----GKVKALKFLYKRGANVNLRRKTK 158 T M Y G L+ L G ++ L+ Sbjct: 358 TTVAMYFKDYMLRSGNYTGLENLINLGLDLFLKDNEG 394 Score = 53.2 bits (126), Expect = 5e-07, Method: Composition-based stats. Identities = 25/132 (18%), Positives = 56/132 (42%), Gaps = 11/132 (8%) Query: 20 RAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLL 79 + ++ ++ A +++ + + +LL+ N+ F++ GW+P+ A D++E L+ Sbjct: 286 KLYSDNFDEILTACEDKSPEFISKLLKT-ENILFEKNHLGWSPIIIAAYHGNMDVIEWLV 344 Query: 80 RHGADPVLRKKNGATPFILAAIA-------GSVKLLKLFLSKGADVNECDFYGFTAFMEA 132 G + R G T +A G+ L+ ++ G D+ D G + F Sbjct: 345 SKGVNINDRNYKGTT---VAMYFKDYMLRSGNYTGLENLINLGLDLFLKDNEGLSVFDYM 401 Query: 133 AVYGKVKALKFL 144 ++ F+ Sbjct: 402 RKNKNIELFNFM 413 Score = 36.6 bits (83), Expect = 0.038, Method: Composition-based stats. Identities = 23/126 (18%), Positives = 50/126 (39%), Gaps = 15/126 (11%) Query: 209 ALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEIND 268 L + +D E I+ LL + + G +P+I+A ++ +++ L+ + + IND Sbjct: 295 ILTACEDKSPEFISKLLKTENI-LFEKNHLGWSPIIIAAYHGNMDVIEWLVSK-GVNIND 352 Query: 269 TDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTA-----RRNYDHSLVKVLLSH 323 + G T + + + + G T +L+ + N S+ + + Sbjct: 353 RNYKGTTVAMYFKDY--------MLRSGNYTGLENLINLGLDLFLKDNEGLSVFDYMRKN 404 Query: 324 GAKEDF 329 E F Sbjct: 405 KNIELF 410 >4BSZ-B nrPDB Length = 202 Score = 62.8 bits (151), Expect = 5e-10, Method: Composition-based stats. Identities = 30/144 (20%), Positives = 50/144 (34%), Gaps = 15/144 (10%) Query: 19 RRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVN----FQEEEGGWTPLHNAVQMSREDI 74 ED +I + D+D ++ + + +E E T LH A + Sbjct: 8 EPLDQEDQDTIILDARAGDLDSLKDIFTTLVSPELLSTCKESESDSTALHMAAANGHIET 67 Query: 75 VELLLRHG----------ADPVLRKKNGATPFILAAIAGSVKLLKLFLS-KGADVNECDF 123 V +L A K G T A++ G + ++KL AD + Sbjct: 68 VRYILETVSRANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVVKLLCDEYEADPFIRNK 127 Query: 124 YGFTAFMEAAVYGKVKALKFLYKR 147 +G A EA GK + + K+ Sbjct: 128 FGHDAIFEAENSGKEEVETYFLKK 151 Score = 60.5 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 25/90 (27%), Positives = 43/90 (47%) Query: 127 TAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKI 186 TA AA G ++ ++++ + + N K + K G TAL A+ G ++V+K+ Sbjct: 54 TALHMAAANGHIETVRYILETVSRANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVVKL 113 Query: 187 LLDEMGADVNACDNMGRNALIHALLSSDDS 216 L DE AD + G +A+ A S + Sbjct: 114 LCDEYEADPFIRNKFGHDAIFEAENSGKEE 143 Score = 55.5 bits (132), Expect = 7e-08, Method: Composition-based stats. Identities = 26/110 (23%), Positives = 44/110 (40%), Gaps = 21/110 (19%) Query: 93 ATPFILAAIAGSVKLLKLFLSKGAD----------VNECDFYGFTAFMEAAVYGKVKALK 142 +T +AA G ++ ++ L + VNE + G TA A++ GK+ +K Sbjct: 53 STALHMAAANGHIETVRYILETVSRANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVVK 112 Query: 143 FLY-KRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEM 191 L + A+ +R K D A+ +A G EV L + Sbjct: 113 LLCDEYEADPFIRNKFGHD----------AIFEAENSGKEEVETYFLKKY 152 Score = 55.1 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 25/127 (19%), Positives = 45/127 (35%), Gaps = 28/127 (22%) Query: 169 ATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDH 228 +TAL AA GH+E ++ +L+ + +A D Sbjct: 53 STALHMAAANGHIETVRYILETVSRANSAEDLK--------------------------- 85 Query: 229 GADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKI 288 A VN + G T L A L +V+ L ++ + + G A+ A +++ Sbjct: 86 -AFVNEVNKTGNTALHWASLNGKLDVVKLLCDEYEADPFIRNKFGHDAIFEAENSGKEEV 144 Query: 289 AELLCKR 295 K+ Sbjct: 145 ETYFLKK 151 >1CSN-A nrPDB Length = 298 Score = 62.8 bits (151), Expect = 5e-10, Method: Composition-based stats. Identities = 45/220 (20%), Positives = 83/220 (37%), Gaps = 46/220 (20%) Query: 370 KIADTSEGGIYLG--FYEKQEVAVKTFCE--GSPRAQREVSCLQSSRENSHLVTFYGSES 425 +I + S G I+ G Q+VA+K +P+ + E + + + Y Sbjct: 17 RIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPNVYYFGQ 76 Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 H + + L +LE LD+ + A+ + VQ +H ++D Sbjct: 77 EGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMAAK----QMLARVQSIHEK-SLVYRD 131 Query: 486 LQPQNILIDSKKA-----AHLADFDKSIKWAGDP-------------------------- 514 ++P N LI + ++ DF +K+ DP Sbjct: 132 IKPDNFLIGRPNSKNANMIYVVDFGM-VKFYRDPVTKQHIPYREKKNLSGTARYMSINTH 190 Query: 515 ----QEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEV 550 Q + DLE LG + +Y +GS+ ++ LKA +N++ Sbjct: 191 LGREQSRRDDLEALGHVFMY-FLRGSLPWQGLKAATNKQK 229 >5UQE-A nrPDB Length = 520 Score = 62.8 bits (151), Expect = 6e-10, Method: Composition-based stats. Identities = 20/101 (19%), Positives = 33/101 (32%), Gaps = 3/101 (2%) Query: 63 LHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVN--E 120 L A + D R + T +AA G V+++K L + VN Sbjct: 421 LLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLL-EACKVNPFP 479 Query: 121 CDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQ 161 D + T EA +G K L + + + + Sbjct: 480 KDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGK 520 Score = 61.6 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 26/92 (28%), Positives = 39/92 (42%), Gaps = 9/92 (9%) Query: 96 FILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR 155 + AA G V L+ F D+ + D+ TA AA G V+ +KFL + Sbjct: 421 LLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEAC------- 473 Query: 156 KTKEDQERLRKGGATALMDAAEKGHVEVLKIL 187 K + + T + +A GH +V KIL Sbjct: 474 --KVNPFPKDRWNNTPMDEALHFGHHDVFKIL 503 Score = 54.3 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 20/96 (20%), Positives = 41/96 (42%), Gaps = 1/96 (1%) Query: 200 NMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLL 259 + ++I+ L ++ DV A+ L D+ R +T L +A + H+ +V+ LL Sbjct: 412 DQRVKSVINLLFAAYTGDVSALRRFALSA-MDMEQRDYDSRTALHVAAAEGHVEVVKFLL 470 Query: 260 EQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKR 295 E + D T + A+ + ++L + Sbjct: 471 EACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEY 506 Score = 53.2 bits (126), Expect = 4e-07, Method: Composition-based stats. Identities = 17/84 (20%), Positives = 34/84 (40%), Gaps = 2/84 (2%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRH-GADPVL 87 L+ A DV +++ ++ ++ + T LH A ++V+ LL +P Sbjct: 421 LLFAAYTGDVSALRRFALSAMDMEQRDYDS-RTALHVAAAEGHVEVVKFLLEACKVNPFP 479 Query: 88 RKKNGATPFILAAIAGSVKLLKLF 111 + + TP A G + K+ Sbjct: 480 KDRWNNTPMDEALHFGHHDVFKIL 503 Score = 46.6 bits (109), Expect = 4e-05, Method: Composition-based stats. Identities = 25/101 (24%), Positives = 36/101 (35%), Gaps = 4/101 (3%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 L+ AA G V L+ D+ D R AL A VE + LL + Sbjct: 421 LLFAAYTGDVSALRRFALSA-MDMEQRDYDSRTALHVAAAEGH---VEVVKFLLEACKVN 476 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSD 272 + TP+ A+ H + + L E + DSD Sbjct: 477 PFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSD 517 Score = 44.3 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 13/63 (20%), Positives = 26/63 (41%) Query: 19 RRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELL 78 + + L A V++V+ LLE F ++ TP+ A+ D+ ++L Sbjct: 444 EQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKIL 503 Query: 79 LRH 81 + Sbjct: 504 QEY 506 >3LLT-A nrPDB Length = 360 Score = 62.4 bits (150), Expect = 7e-10, Method: Composition-based stats. Identities = 51/324 (15%), Positives = 91/324 (28%), Gaps = 113/324 (34%) Query: 370 KIADTSEGGIYLGFY--EKQEVAVKTFCEGSP---RAQREVSCLQS----SRENSHLVTF 420 K+ D + G + L + K+ AVK A+ E L+ N+++V + Sbjct: 42 KMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDINNNNIVKY 101 Query: 421 YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG 480 +G + H+ + +L ++ + E + I KA+ L Sbjct: 102 HGKFMYYDHMCLIFEPLGPSL---YEIITRNNYNGFHIEDIKLYCIEILKALNYL-RKMS 157 Query: 481 YTHQDLQPQNILIDSK-------------------------KAAHLADFDKSIKWAGD-- 513 TH DL+P+NIL+D L DF + D Sbjct: 158 LTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFG-CATFKSDYH 216 Query: 514 -----------PQ-------EVKRDLEDLGRLVLYVVKKGSISFED-------------- 541 P+ +V D+ G + L + GS+ F Sbjct: 217 GSIINTRQYRAPEVILNLGWDVSSDMWSFGCV-LAELYTGSLLFRTHEHMEHLAMMESII 275 Query: 542 --------------------LKAQSNEEVVQ--------------LSPDEETK-----DL 562 K + + L + K D Sbjct: 276 QPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYKIIKHELFCDF 335 Query: 563 IHRLFHPGEHVRDCLSDLLGHPFF 586 ++ + +R ++LL H F Sbjct: 336 LYSILQIDPTLRPSPAELLKHKFL 359 >4NT4-A nrPDB Length = 312 Score = 62.4 bits (150), Expect = 7e-10, Method: Composition-based stats. Identities = 47/291 (16%), Positives = 97/291 (33%), Gaps = 57/291 (19%) Query: 363 FFIDEKYKIADTSEGGIY------LGFYEKQEVAVKT--FCEGSPRAQREVSCLQSSREN 414 + +++ G + Y + VA+K +P+ E + + Sbjct: 8 LMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSH 67 Query: 415 -----SHLVTFYGSESHRG-HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI 468 + Y + G + + + L +LE ++ + A+ +L I Sbjct: 68 ADNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRI 127 Query: 469 FKAVQELHLSCGYTHQDLQPQNILIDSKKA-----AHLADFDKSIKW------------- 510 + +H S ++D++P+N LI H+ DF + ++ Sbjct: 128 ----EYVH-SRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYRE 182 Query: 511 ----------------AGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLS 554 G Q + DLE LG + +Y +GS+ ++ LKA + +E Q Sbjct: 183 HKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMY-FLRGSLPWQGLKADTLKERYQKI 241 Query: 555 PDEETKDLIHRLFHPGEHVRDCLSDLLGH-PFFWTWESRY--RTLRNVGNE 602 D + I L + FF T + + R +++ + Sbjct: 242 GDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDR 292 >5E8V-A nrPDB Length = 316 Score = 62.4 bits (150), Expect = 8e-10, Method: Composition-based stats. Identities = 37/181 (20%), Positives = 68/181 (37%), Gaps = 29/181 (16%) Query: 368 KYKIADTSEGGIYLGFYEK------QEVAVKTFC-EGSPRAQREVSCLQSS-RENSHLVT 419 + +Y ++ + VAVK F E + E ++ +++ Sbjct: 14 DTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQ 73 Query: 420 FYGSESHRGHL----FVCVTL-CEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE 474 F +E + L ++ + L+ L H V + ED R + SS+ + + Sbjct: 74 FLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH----VISWEDL--RKLGSSLARGIAH 127 Query: 475 LHLSCG--------YTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGR 526 LH H+DL+ NIL+ + L DF S++ DP DL + G+ Sbjct: 128 LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRL--DPTLSVDDLANSGQ 185 Query: 527 L 527 + Sbjct: 186 V 186 >2X7G-A nrPDB Length = 389 Score = 62.0 bits (149), Expect = 1e-09, Method: Composition-based stats. Identities = 29/158 (18%), Positives = 59/158 (37%), Gaps = 21/158 (13%) Query: 354 YRPMIGKLKFFIDEKYKIADTSEGGIYLGFYE------KQEVAVKTFCEG---SPRAQRE 404 Y P+ K+ + +Y + G + + K+ VA+K + A E Sbjct: 20 YHPV--KIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDE 77 Query: 405 VSCLQSSREN----SH---LVTFYGSESHRGH--LFVCVTLCEQTLEACLDVHRGEDVEN 455 + L+ RE+ + +V G + VC+ E L + + Sbjct: 78 IKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVF-EVLGHHLLKWIIKSNYQG 136 Query: 456 EEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILI 493 ++++ + + + LH C H D++P+NIL+ Sbjct: 137 LPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM 174 Score = 30.4 bits (67), Expect = 2.7, Method: Composition-based stats. Identities = 5/34 (14%), Positives = 11/34 (32%) Query: 555 PDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWT 588 + D + + R + L HP+ + Sbjct: 356 DAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 389 >5U0J-A nrPDB Length = 140 Score = 61.6 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 21/103 (20%), Positives = 34/103 (33%), Gaps = 3/103 (2%) Query: 63 LHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVN--E 120 L A + D R + T +AA G V+++K L + VN Sbjct: 28 LLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLL-EACKVNPFP 86 Query: 121 CDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQER 163 D + T EA +G K L + + + +E Sbjct: 87 KDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKEN 129 Score = 59.3 bits (142), Expect = 5e-09, Method: Composition-based stats. Identities = 26/92 (28%), Positives = 39/92 (42%), Gaps = 9/92 (9%) Query: 96 FILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR 155 + AA G V L+ F D+ + D+ TA AA G V+ +KFL + Sbjct: 28 LLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEAC------- 80 Query: 156 KTKEDQERLRKGGATALMDAAEKGHVEVLKIL 187 K + + T + +A GH +V KIL Sbjct: 81 --KVNPFPKDRWNNTPMDEALHFGHHDVFKIL 110 Score = 51.6 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 20/92 (21%), Positives = 40/92 (43%), Gaps = 1/92 (1%) Query: 204 NALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEH 263 ++I+ L ++ DV A+ L D+ R +T L +A + H+ +V+ LLE Sbjct: 23 KSVINLLFAAYTGDVSALRRFALSA-MDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACK 81 Query: 264 IEINDTDSDGKTALLLAVELKLKKIAELLCKR 295 + D T + A+ + ++L + Sbjct: 82 VNPFPKDRWNNTPMDEALHFGHHDVFKILQEY 113 Score = 50.9 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 17/84 (20%), Positives = 34/84 (40%), Gaps = 2/84 (2%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRH-GADPVL 87 L+ A DV +++ ++ ++ + T LH A ++V+ LL +P Sbjct: 28 LLFAAYTGDVSALRRFALSAMDMEQRDYDS-RTALHVAAAEGHVEVVKFLLEACKVNPFP 86 Query: 88 RKKNGATPFILAAIAGSVKLLKLF 111 + + TP A G + K+ Sbjct: 87 KDRWNNTPMDEALHFGHHDVFKIL 110 Score = 44.7 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 25/101 (24%), Positives = 36/101 (35%), Gaps = 4/101 (3%) Query: 172 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 L+ AA G V L+ D+ D R AL A VE + LL + Sbjct: 28 LLFAAYTGDVSALRRFALSA-MDMEQRDYDSRTALHVAAAEGH---VEVVKFLLEACKVN 83 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSD 272 + TP+ A+ H + + L E + DSD Sbjct: 84 PFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSD 124 Score = 42.8 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 13/63 (20%), Positives = 26/63 (41%) Query: 19 RRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELL 78 + + L A V++V+ LLE F ++ TP+ A+ D+ ++L Sbjct: 51 EQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKIL 110 Query: 79 LRH 81 + Sbjct: 111 QEY 113 Score = 39.3 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 23/100 (23%), Positives = 36/100 (36%), Gaps = 10/100 (10%) Query: 129 FMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188 + AA G V AL+ ++ R TAL AA +GHVEV+K LL Sbjct: 28 LLFAAYTGDVSALRRFALSAMDMEQRDYDSR----------TALHVAAAEGHVEVVKFLL 77 Query: 189 DEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDH 228 + + D + AL + + + + Sbjct: 78 EACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQY 117 >2CMW-A nrPDB Length = 310 Score = 60.9 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 45/247 (18%), Positives = 83/247 (33%), Gaps = 45/247 (18%) Query: 370 KIADTSEGGIYLG--FYEKQEVAVKT--FCEGSPRAQREVSCLQSS-RENSHLVTFYGSE 424 KI + G + LG Y + VA+K +P+ E + L Y Sbjct: 7 KIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFG 66 Query: 425 SHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQ 484 + + + L +LE D+ + + + ++ +H S ++ Sbjct: 67 PCGKYNAMVLELLGPSLEDLFDLC----DRTFTLKTVLMIAIQLLSRMEYVH-SKNLIYR 121 Query: 485 DLQPQNILIDSKKA-----AHLADFDKSIKWA---------------------------- 511 D++P+N LI + H+ DF + ++ Sbjct: 122 DVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTH 181 Query: 512 -GDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPG 570 G Q + DLE LG + +Y +GS+ ++ LKA + +E Q D + I L Sbjct: 182 LGKEQSRRDDLEALGHMFMY-FLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENF 240 Query: 571 EHVRDCL 577 Sbjct: 241 PEEMATY 247 >4XHL-A nrPDB Length = 394 Score = 60.5 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 44/219 (20%), Positives = 80/219 (36%), Gaps = 46/219 (21%) Query: 370 KIADTSEGGIYLG--FYEKQEVAVK--TFCEGSPRAQREVSCLQSSRENSHL--VTFYGS 423 KI S G IY G +EVA++ + P+ E + + + ++G Sbjct: 14 KIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRYLSGGVGIPFIRWFGR 73 Query: 424 ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTH 483 E + + L +LE + + + +F +Q +H + H Sbjct: 74 EGEYNA--MVIDLLGPSLEDLFNYCHRR----FSFKTVIMLALQMFCRIQYIHG-RSFIH 126 Query: 484 QDLQPQNILID---SKKAAHLADFDKSIKWA----------------------------- 511 +D++P N L+ H+ DF S K+ Sbjct: 127 RDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHL 186 Query: 512 GDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEV 550 G Q + DLE LG +++Y KGS+ ++ LKA + ++ Sbjct: 187 GIEQSRRDDLESLGYVLIY-FCKGSLPWQGLKATTKKQK 224 >6J6I-B nrPDB Length = 351 Score = 60.5 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 28/159 (17%), Positives = 52/159 (32%), Gaps = 16/159 (10%) Query: 380 YLGFYEKQEVAVKTFCEGSPRAQR--------EVSCLQSSRENSHLVTFYGSESHRGHLF 431 Y G E + +K F E +R ++ +S+ + G Sbjct: 75 YRGEIEDRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPV 134 Query: 432 VCVTLCE---QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG--YTHQDL 486 + E + V+ E + + I AV LH + H+D+ Sbjct: 135 LVFEFAEHGAMNQRGGVIVNGEESLLPWSVRL--KIGKEIANAVTYLHTAFPKIIIHRDV 192 Query: 487 QPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLG 525 +P ++ +D A L+D SI ++ + LG Sbjct: 193 KPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAE-WVLG 230 >5X1R-A nrPDB Length = 302 Score = 60.1 bits (144), Expect = 4e-09, Method: Composition-based stats. Identities = 40/226 (17%), Positives = 71/226 (31%), Gaps = 41/226 (18%) Query: 392 KTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGE 451 KTF G +E L + L+ G ++ T L + E Sbjct: 77 KTFQAGLNSFIQEARLLARFS-HPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPE 135 Query: 452 DVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWA 511 ++ + + R +L +F A+ +H GY H+D+ NI I + L DF + K Sbjct: 136 KID---EAWIRRLLPPLFSAINTIHQE-GYLHRDISLDNIQIQESQLPVLLDFGSARKEI 191 Query: 512 GDPQEVKR-------------------------DLEDLGRLVLYVVKKGSISFEDLKAQS 546 G+ + D+ LG + L+ + GS + Sbjct: 192 GNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAV-LHTLIVGSPPPVSVVRSI 250 Query: 547 NEEVVQLSP------DEETKDLIHRLFHPGEHVRDC----LSDLLG 582 + L+ E + R R +++LL Sbjct: 251 EDSYQPLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEMAELLE 296 >4WUA-A nrPDB Length = 401 Score = 59.7 bits (143), Expect = 4e-09, Method: Composition-based stats. Identities = 24/157 (15%), Positives = 55/157 (35%), Gaps = 23/157 (14%) Query: 360 KLKFFIDEKYKIADTSEGGIYLGFYE------KQEVAVKTFCEG---SPRAQREVSCLQS 410 K+ + +Y + G + + K+ VA+K + A E+ L+S Sbjct: 34 KIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKS 93 Query: 411 SREN----SH---LVTFYGSES----HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDE 459 R + + +V + H+ + + L + + + Sbjct: 94 VRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLP--- 150 Query: 460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK 496 + ++ + + + LH C H D++P+NIL+ Sbjct: 151 CVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVN 187 >4DX2-A nrPDB Length = 259 Score = 59.7 bits (143), Expect = 5e-09, Method: Composition-based stats. Identities = 34/162 (20%), Positives = 54/162 (33%), Gaps = 29/162 (17%) Query: 59 GWTPLHNAVQMSREDIVELLLRHGADPVLRKKN--------------GATPFILAAIAGS 104 G T LH A++ + VELL+ GAD + + G P LAA Sbjct: 91 GQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQ 150 Query: 105 VKLLKLFLSKG---ADVNECDFYGFTAFM-EAAVYGK--------VKALKFLYKRGANVN 152 ++ AD+ D G T A+ K L + A + Sbjct: 151 PHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLF 210 Query: 153 LRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGAD 194 + L G + LM AA+ G + + + ++ D Sbjct: 211 P---DSNLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTD 249 Score = 49.7 bits (117), Expect = 5e-06, Method: Composition-based stats. Identities = 38/170 (22%), Positives = 57/170 (33%), Gaps = 37/170 (21%) Query: 140 ALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAA---EKGHVEVLKILLD------E 190 L FL +++ +++ R G T L A G + + +LLD Sbjct: 22 LLPFLLTH------KKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGN 75 Query: 191 MGADVN--ACDNMGR-NALIHALLSSDDSDVEAITHLLLDHGADVNVRGE---------- 237 M +N D R +H + LL+ GADV+ + Sbjct: 76 MREFINSPFRDIYYRGQTALHIAIERRCKHY---VELLVAQGADVHAQARGRFFQPKDEG 132 Query: 238 ----RGKTPLILAVEKKHLGLVQRLLEQEH--IEINDTDSDGKTALLLAV 281 G+ PL LA +V L E H ++ DS G T L V Sbjct: 133 GYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALV 182 Score = 37.8 bits (86), Expect = 0.019, Method: Composition-based stats. Identities = 12/30 (40%), Positives = 17/30 (56%) Query: 273 GKTALLLAVELKLKKIAELLCKRGASTDCG 302 G+TAL +A+E + K ELL +GA Sbjct: 91 GQTALHIAIERRCKHYVELLVAQGADVHAQ 120 >4XHH-A nrPDB Length = 403 Score = 59.3 bits (142), Expect = 6e-09, Method: Composition-based stats. Identities = 44/219 (20%), Positives = 80/219 (36%), Gaps = 46/219 (21%) Query: 370 KIADTSEGGIYLG--FYEKQEVAVK--TFCEGSPRAQREVSCLQSSRENSHL--VTFYGS 423 KI S G IY G +EVA++ + P+ E + + + ++G Sbjct: 14 KIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYKYLSGGVGIPFIRWFGR 73 Query: 424 ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTH 483 E + + L +LE + + + + + VQ +H + H Sbjct: 74 EGEYNA--MVIDLLGPSLEDLFNYCHRK----FSFKTVIMLALQMICRVQYIHG-RSFIH 126 Query: 484 QDLQPQNILID---SKKAAHLADFDKSIKWA----------------------------- 511 +D++P N L+ H+ DF S K+ Sbjct: 127 RDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHL 186 Query: 512 GDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEV 550 G Q + DLE LG +++Y KGS+ ++ LKA + ++ Sbjct: 187 GIEQSRRDDLESLGYMLIY-FCKGSLPWQGLKATTKKQK 224 >5J0A-A nrPDB Length = 300 Score = 58.9 bits (141), Expect = 7e-09, Method: Composition-based stats. Identities = 39/283 (13%), Positives = 87/283 (30%), Gaps = 73/283 (25%) Query: 370 KIADTSEGGIYLGFYEKQEV-----AVKTFCEGS---------PRAQREVSCLQSSRENS 415 K+ + +YL + + AVK R E L+S + Sbjct: 16 KLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLH-HP 74 Query: 416 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLS---SIFKAV 472 ++V Y + + +C+ + ++ D+ +++ A +L ++ + + Sbjct: 75 NIVG-YRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGL 133 Query: 473 QELHLSCGYTHQDLQPQNILIDSK-KAAHLADFDKSI----------------------- 508 + LH H D++ N++I + + D S+ Sbjct: 134 KYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPWKP 193 Query: 509 KWAGDPQEV---KRDLEDLGRLVLYVVKKGSIS-------------------FED-LKAQ 545 K A + V K D+ G L L+ + SI F+D Sbjct: 194 KEAVEENGVITDKADIFAFG-LTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYYA 252 Query: 546 SNEEVVQLSPDE------ETKDLIHRLFHPGEHVRDCLSDLLG 582 + ++ +E + +L + R + ++ Sbjct: 253 ALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVE 295 >6CUD-A nrPDB Length = 806 Score = 58.9 bits (141), Expect = 8e-09, Method: Composition-based stats. Identities = 37/179 (20%), Positives = 62/179 (34%), Gaps = 37/179 (20%) Query: 1 MESRDHNNPQEGPT---SSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLE--GGANVNFQE 55 M + GP + G E+ L A + ++ +V+++LE NVN + Sbjct: 1 MREKGRRQAVRGPAFMFNDRGTSLTAEEERFL-DAAEYGNIPVVRKMLEESKTLNVNCVD 59 Query: 56 EEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKG 115 G L AV ++ ELLL+ + G +LA G V++++ L+ Sbjct: 60 YMG-QNALQLAVGNEHLEVTELLLKK----ENLARIGD-ALLLAISKGYVRIVEAILNHP 113 Query: 116 A-------------------DVNECDFYGF------TAFMEAAVYGKVKALKFLYKRGA 149 D D G T + AA K + + L +GA Sbjct: 114 GFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGA 172 Score = 55.1 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 40/175 (22%), Positives = 66/175 (37%), Gaps = 42/175 (24%) Query: 96 FILAAIAGSVKLLKLFL--SKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNL 153 F+ AA G++ +++ L SK +VN D+ G A A ++ + L K Sbjct: 31 FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLK------- 83 Query: 154 RRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSS 213 +E L + G AL+ A KG+V +++ +L+ G +S Sbjct: 84 -------KENLARIGD-ALLLAISKGYVRIVEAILNHPG-----------------FAAS 118 Query: 214 DDSDVEAITHLLLDHGADVNVRGERGK------TPLILAVEKKHLGLVQRLLEQE 262 + L D D E G TP+ILA + +V LL + Sbjct: 119 KRLTLSPCEQELQDD--DFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKG 171 Score = 51.2 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 28/112 (25%), Positives = 51/112 (45%), Gaps = 5/112 (4%) Query: 213 SDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQ-EHIEINDTDS 271 V + D G + ER A E ++ +V+++LE+ + + +N D Sbjct: 5 GRRQAVRGPAFMFNDRGTSLTAEEERFLD----AAEYGNIPVVRKMLEESKTLNVNCVDY 60 Query: 272 DGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSH 323 G+ AL LAV + ++ ELL K+ GD ++ A +V+ +L+H Sbjct: 61 MGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNH 112 Score = 50.5 bits (119), Expect = 3e-06, Method: Composition-based stats. Identities = 36/153 (23%), Positives = 66/153 (43%), Gaps = 34/153 (22%) Query: 173 MDAAEKGHVEVLKILLDEMGA-DVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 +DAAE G++ V++ +L+E +VN D MG+NAL A+ ++ +T LLL Sbjct: 32 LDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAV----GNEHLEVTELLLKKENL 87 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHI------------------EINDTDSDG 273 + L+LA+ K ++ +V+ +L + D DG Sbjct: 88 ARIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDG 142 Query: 274 K------TALLLAVELKLKKIAELLCKRGASTD 300 T ++LA + ++ +L +GA + Sbjct: 143 TRFSPDITPIILAAHCQKYEVVHMLLMKGARIE 175 Score = 48.9 bits (115), Expect = 7e-06, Method: Composition-based stats. Identities = 22/143 (15%), Positives = 43/143 (30%), Gaps = 22/143 (15%) Query: 65 NAVQMSREDIVELLLRHGA--DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECD 122 +A + +V +L + G LA +++ +L L K D Sbjct: 33 DAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD 92 Query: 123 FYGFTAFMEAAVYGKVKALKFLYKR------------GANVNLRRKTKEDQERLR---KG 167 A + A G V+ ++ + L+ + Sbjct: 93 -----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSP 147 Query: 168 GATALMDAAEKGHVEVLKILLDE 190 T ++ AA EV+ +LL + Sbjct: 148 DITPIILAAHCQKYEVVHMLLMK 170 >3LVQ-E nrPDB Length = 497 Score = 58.9 bits (141), Expect = 8e-09, Method: Composition-based stats. Identities = 22/90 (24%), Positives = 38/90 (42%), Gaps = 3/90 (3%) Query: 63 LHNAVQMSR---EDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVN 119 LH AV+++ +V+ ++++G + +G T AA+ LKL L A V Sbjct: 175 LHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVG 234 Query: 120 ECDFYGFTAFMEAAVYGKVKALKFLYKRGA 149 + G TA A + + L + A Sbjct: 235 TVNEAGETALDIARKKHHKECEELLEQAQA 264 Score = 58.2 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 24/108 (22%), Positives = 47/108 (43%), Gaps = 4/108 (3%) Query: 4 RDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPL 63 +D P GP + + + HL +K + LV +++ G +++ + +G T L Sbjct: 156 QDFGQPLPGPDAQAPEELVL---HLAVKVANQASLPLVDFIIQNGGHLDAKAADGN-TAL 211 Query: 64 HNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLF 111 H A ++ D ++LLL+ A + G T +A + +L Sbjct: 212 HYAALYNQPDCLKLLLKGRALVGTVNEAGETALDIARKKHHKECEELL 259 Score = 57.4 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 24/123 (19%), Positives = 46/123 (37%), Gaps = 11/123 (8%) Query: 187 LLDEMGADVNACDNMGRNA----------LIHALLSSDDSDVEAITHLLLDHGADVNVRG 236 LL + A N D ++H + + + ++ +G ++ + Sbjct: 145 LLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPLVDFIIQNGGHLDAKA 204 Query: 237 ERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRG 296 G T L A ++ LL + + + G+TAL +A + K+ ELL + Sbjct: 205 ADGNTALHYAALYNQPDCLKLLL-KGRALVGTVNEAGETALDIARKKHHKECEELLEQAQ 263 Query: 297 AST 299 A T Sbjct: 264 AGT 266 Score = 55.9 bits (133), Expect = 6e-08, Method: Composition-based stats. Identities = 25/95 (26%), Positives = 38/95 (40%), Gaps = 13/95 (13%) Query: 96 FILAAIAGS---VKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVN 152 LA + + L+ + G ++ G TA AA+Y + LK L K A V Sbjct: 175 LHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVG 234 Query: 153 LRRKTKEDQERLRKGGATALMDAAEKGHVEVLKIL 187 + + G TAL A +K H E ++L Sbjct: 235 ----------TVNEAGETALDIARKKHHKECEELL 259 Score = 41.6 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 25/121 (20%), Positives = 39/121 (32%), Gaps = 24/121 (19%) Query: 128 AFMEA---AVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVL 184 A A + + F+ + G +++ + G TAL AA + L Sbjct: 174 VLHLAVKVANQASLPLVDFIIQNGGHLDAKAAD----------GNTALHYAALYNQPDCL 223 Query: 185 KILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLI 244 K+LL + A V + G AL A + LL A PL Sbjct: 224 KLLL-KGRALVGTVNEAGETALDIA----RKKHHKECEELLEQAQAGTFAF------PLH 272 Query: 245 L 245 + Sbjct: 273 V 273 Score = 33.1 bits (74), Expect = 0.47, Method: Composition-based stats. Identities = 20/77 (25%), Positives = 29/77 (37%), Gaps = 7/77 (9%) Query: 22 AVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRH 81 A + N L A D ++ LL+G A V E G T L A + ++ ELL + Sbjct: 204 AADGNTALHYAALYNQPDCLKLLLKGRALVGTV-NEAGETALDIARKKHHKECEELLEQA 262 Query: 82 GADPVLRKKNGATPFIL 98 A P + Sbjct: 263 QAGTFAF------PLHV 273 >6EQI-C nrPDB Length = 433 Score = 58.6 bits (140), Expect = 9e-09, Method: Composition-based stats. Identities = 38/278 (13%), Positives = 82/278 (29%), Gaps = 83/278 (29%) Query: 373 DTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQ-SSRENSHLVTFYGSESHR---- 427 +++ I Y + A+ F + +S + + ++V Y + R Sbjct: 59 ESNSTAILKAMYRETVPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDL 118 Query: 428 -----------------------GHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNV 464 LF+ + + TL+ L + + + Sbjct: 119 QCNKQLYPEALPPRINPEGSGRNMSLFLVMKRYDCTLKEYL------RDKTPNMRSSILL 172 Query: 465 LSSIFKAVQELHLSCGYTHQDLQPQNILI-----DSKKAAHLADFDKSI----------- 508 LS + +AV +++ +H+DL+ NIL+ D+ + DF + Sbjct: 173 LSQLLEAVAHMNI-HNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPY 231 Query: 509 -----KWAGDP------------------QEVKRDLEDLGRLVLYVVKKGSISFEDLKAQ 545 G+ K DL +G + Y + F D + Sbjct: 232 RSEDQDKGGNRALMAPEIANAKPGTFSWLNYKKSDLWAVGA-IAYEIFNIDNPFYDKTMK 290 Query: 546 ------SNEEVVQLSPDE--ETKDLIHRLFHPGEHVRD 575 E++ +L ++L+ + + R Sbjct: 291 LLSKSYKEEDLPELPDTIPFIIRNLVSNMLSRSTNKRL 328 >3SOC-A nrPDB Length = 322 Score = 58.2 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 28/159 (17%), Positives = 61/159 (38%), Gaps = 20/159 (12%) Query: 372 ADTSEGGIYLGFYEKQEVAVKTFC-EGSPRAQREVSCLQS-SRENSHLVTFYGSESHRG- 428 A G ++ + VAVK F + Q E ++ +++ F G+E Sbjct: 33 ARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTS 92 Query: 429 ---HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSC------ 479 L++ E+ + D + V E ++ ++ + + LH Sbjct: 93 VDVDLWLITAFHEKG--SLSDFLKANVVSWNELC---HIAETMARGLAYLHEDIPGLKDG 147 Query: 480 ---GYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQ 515 +H+D++ +N+L+ + A +ADF ++K+ Sbjct: 148 HKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKS 186 >5OAT-A nrPDB Length = 411 Score = 58.2 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 42/330 (12%), Positives = 94/330 (28%), Gaps = 80/330 (24%) Query: 409 QSSRENSHLVTFYGSESHRG-----------------HLFVCVTLCEQTLEACLDVHRGE 451 + + ++V + + LF+ + + L++ L Sbjct: 93 KHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLFLLMKRYDCNLQSFLS----- 147 Query: 452 DVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA----AHLADFDKS 507 + +L+ + + V + + G H+DL+ N+L+D+ + ++DF Sbjct: 148 --TAPSTRTSLLLLAQLLEGVAHM-TAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCC 204 Query: 508 IKW----------------------------AGDP------QEVKRDLEDLGRLVLYVVK 533 + P K DL +G + + Sbjct: 205 LADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFN 264 Query: 534 KGSISFEDLKAQS-NEEVVQLS--PDE---ETKDLIHRLFHPGEHVR--DCLSDLLGHPF 585 + + + ++ N + L PDE + L+ L + R ++ + F Sbjct: 265 CHNPFYGPSRLKNFNYKEGDLPKLPDEVPTVIQALVANLLKRNPNKRLDPEVAANVCQLF 324 Query: 586 FWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMN 645 W + + V + EIL+ L ++ + Sbjct: 325 LWAPSTWLKPGLKV---------PTSGEILQWLLSLTTKVLCEGKINNKSFGAAFTRNWR 375 Query: 646 KFYEKRGNFYQNTVGDLLKFIRNLGEHIDE 675 + Y + L +RN I E Sbjct: 376 RTYPEYLLISSFLCRAKLANVRNALHWIQE 405 >2B0O-E nrPDB Length = 301 Score = 58.2 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 22/90 (24%), Positives = 38/90 (42%), Gaps = 3/90 (3%) Query: 63 LHNAVQMSR---EDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVN 119 LH AV+++ +V+ ++++G + +G T AA+ LKL L A V Sbjct: 194 LHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVG 253 Query: 120 ECDFYGFTAFMEAAVYGKVKALKFLYKRGA 149 + G TA A + + L + A Sbjct: 254 TVNEAGETALDIARKKHHKECEELLEQAQA 283 Score = 57.8 bits (138), Expect = 2e-08, Method: Composition-based stats. Identities = 24/108 (22%), Positives = 47/108 (43%), Gaps = 4/108 (3%) Query: 4 RDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPL 63 +D P GP + + + HL +K + LV +++ G +++ + +G T L Sbjct: 175 QDFGQPLPGPDAQAPEELVL---HLAVKVANQASLPLVDFIIQNGGHLDAKAADGN-TAL 230 Query: 64 HNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLF 111 H A ++ D ++LLL+ A + G T +A + +L Sbjct: 231 HYAALYNQPDCLKLLLKGRALVGTVNEAGETALDIARKKHHKECEELL 278 Score = 56.6 bits (135), Expect = 4e-08, Method: Composition-based stats. Identities = 24/123 (19%), Positives = 46/123 (37%), Gaps = 11/123 (8%) Query: 187 LLDEMGADVNACDNMGRNA----------LIHALLSSDDSDVEAITHLLLDHGADVNVRG 236 LL + A N D ++H + + + ++ +G ++ + Sbjct: 164 LLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPLVDFIIQNGGHLDAKA 223 Query: 237 ERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRG 296 G T L A ++ LL + + + G+TAL +A + K+ ELL + Sbjct: 224 ADGNTALHYAALYNQPDCLKLLL-KGRALVGTVNEAGETALDIARKKHHKECEELLEQAQ 282 Query: 297 AST 299 A T Sbjct: 283 AGT 285 Score = 55.5 bits (132), Expect = 9e-08, Method: Composition-based stats. Identities = 25/95 (26%), Positives = 38/95 (40%), Gaps = 13/95 (13%) Query: 96 FILAAIAGS---VKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVN 152 LA + + L+ + G ++ G TA AA+Y + LK L K A V Sbjct: 194 LHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVG 253 Query: 153 LRRKTKEDQERLRKGGATALMDAAEKGHVEVLKIL 187 + + G TAL A +K H E ++L Sbjct: 254 ----------TVNEAGETALDIARKKHHKECEELL 278 Score = 40.8 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 25/121 (20%), Positives = 39/121 (32%), Gaps = 24/121 (19%) Query: 128 AFMEA---AVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVL 184 A A + + F+ + G +++ + G TAL AA + L Sbjct: 193 VLHLAVKVANQASLPLVDFIIQNGGHLDAKAAD----------GNTALHYAALYNQPDCL 242 Query: 185 KILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLI 244 K+LL + A V + G AL A + LL A PL Sbjct: 243 KLLL-KGRALVGTVNEAGETALDIA----RKKHHKECEELLEQAQAGTFAF------PLH 291 Query: 245 L 245 + Sbjct: 292 V 292 Score = 32.8 bits (73), Expect = 0.60, Method: Composition-based stats. Identities = 20/77 (25%), Positives = 29/77 (37%), Gaps = 7/77 (9%) Query: 22 AVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRH 81 A + N L A D ++ LL+G A V E G T L A + ++ ELL + Sbjct: 223 AADGNTALHYAALYNQPDCLKLLLKGRALVGTV-NEAGETALDIARKKHHKECEELLEQA 281 Query: 82 GADPVLRKKNGATPFIL 98 A P + Sbjct: 282 QAGTFAF------PLHV 292 >2QLU-A nrPDB Length = 314 Score = 58.2 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 47/261 (18%), Positives = 93/261 (35%), Gaps = 57/261 (21%) Query: 372 ADTSEGGIYLGFYEKQEVAVKTFC---EGSPRAQREVSCLQSSRENSHLVTFYGSESHRG 428 A G ++ VAVK F + S +++RE+ ++ +L+ F +E Sbjct: 24 ARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREI-FSTPGMKHENLLQFIAAEKRGS 82 Query: 429 HLFVCVTLCEQTLEA--CLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSC------- 479 +L V + L + D +G + E +S + + LH Sbjct: 83 NLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMS---RGLSYLHEDVPWCRGEG 139 Query: 480 ---GYTHQDLQPQNILIDSKKAAHLADFDKSIKWA-GDP--------------------- 514 H+D + +N+L+ S A LADF ++++ G P Sbjct: 140 HKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEG 199 Query: 515 -------QEVKRDLEDLGRLVLYVV---KKGSISFEDLKAQSNEEVVQLSPDEETKDLIH 564 ++ D+ +G ++ +V K ++ EE+ Q EE ++++ Sbjct: 200 AINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVV 259 Query: 565 RLFHPGEHVRDCLS-DLLGHP 584 + +R + L HP Sbjct: 260 H-----KKMRPTIKDHWLKHP 275 >6CV9-A nrPDB Length = 842 Score = 57.8 bits (138), Expect = 2e-08, Method: Composition-based stats. Identities = 35/160 (21%), Positives = 61/160 (38%), Gaps = 34/160 (21%) Query: 17 SGRRAAVEDNHLLIKAVQNEDVDLVQQLLE--GGANVNFQEEEGGWTPLHNAVQMSREDI 74 G ++E+ L A + ++ +V+++LE NVN + G L AV +I Sbjct: 2 MGSMLSIEEERFL-DAAEYGNIPVVRKMLEECHSLNVNCVDYMG-QNALQLAVANEHLEI 59 Query: 75 VELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGA------------------ 116 ELLL+ + G +LA G V++++ L+ A Sbjct: 60 TELLLKK----ENLSRVGD-ALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQ 114 Query: 117 -DVNECDFYGF------TAFMEAAVYGKVKALKFLYKRGA 149 D D G T + AA + + + L ++GA Sbjct: 115 DDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGA 154 Score = 54.3 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 38/175 (21%), Positives = 70/175 (40%), Gaps = 6/175 (3%) Query: 246 AVEKKHLGLV-QRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDL 304 A E ++ +V + L E + +N D G+ AL LAV + +I ELL K+ + GD Sbjct: 16 AAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDA 75 Query: 305 VMTARRNYDHSLVKVLLSHGA---KEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKL 361 ++ A +V+ +L+H A + + Q + A +D R + + Sbjct: 76 LLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPII 135 Query: 362 KFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSH 416 ++Y+I T + K E S + + + SR N++ Sbjct: 136 LAAHCQEYEIVHTLLRKG-ARIERPHDYFCK-CTECSQKQKHDSFSHSRSRINAY 188 Score = 53.9 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 36/175 (20%), Positives = 63/175 (36%), Gaps = 42/175 (24%) Query: 96 FILAAIAGSVKLLKLFL--SKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNL 153 F+ AA G++ +++ L +VN D+ G A A ++ + L K Sbjct: 13 FLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLK------- 65 Query: 154 RRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSS 213 +E L + G AL+ A KG+V +++ +L+ H + Sbjct: 66 -------KENLSRVGD-ALLLAISKGYVRIVEAILN------------------HPAFAE 99 Query: 214 DDSDVEAITHLLLDHGADVNVRGERGK------TPLILAVEKKHLGLVQRLLEQE 262 + + L D E G TP+ILA + +V LL + Sbjct: 100 GKRLATSPSQSELQQD-DFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKG 153 Score = 53.6 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 24/143 (16%), Positives = 45/143 (31%), Gaps = 22/143 (15%) Query: 65 NAVQMSREDIVELLLR--HGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECD 122 +A + +V +L H + G LA +++ +L L K D Sbjct: 15 DAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGD 74 Query: 123 FYGFTAFMEAAVYGKVKALKFLYKR-----GANVNLRRKTKEDQERLRKGGA-------- 169 A + A G V+ ++ + G + E Q+ Sbjct: 75 -----ALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSH 129 Query: 170 --TALMDAAEKGHVEVLKILLDE 190 T ++ AA E++ LL + Sbjct: 130 DVTPIILAAHCQEYEIVHTLLRK 152 Score = 48.9 bits (115), Expect = 8e-06, Method: Composition-based stats. Identities = 39/153 (25%), Positives = 65/153 (42%), Gaps = 34/153 (22%) Query: 173 MDAAEKGHVEVLKILLDE-MGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 +DAAE G++ V++ +L+E +VN D MG+NAL A+ + IT LLL Sbjct: 14 LDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLE----ITELLLKK--- 66 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQE------------------HIEINDTDSDG 273 G L+LA+ K ++ +V+ +L + D DG Sbjct: 67 -ENLSRVGD-ALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDEDG 124 Query: 274 K------TALLLAVELKLKKIAELLCKRGASTD 300 T ++LA + +I L ++GA + Sbjct: 125 TRFSHDVTPIILAAHCQEYEIVHTLLRKGARIE 157 >5CLR-A nrPDB Length = 451 Score = 56.6 bits (135), Expect = 4e-08, Method: Composition-based stats. Identities = 32/164 (19%), Positives = 56/164 (34%), Gaps = 18/164 (10%) Query: 349 DLHRIYRPMIGKLK---FFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREV 405 L I P K+ E++K+ +G Y +VK E E Sbjct: 73 SLKPIIVPTENKISGGGKSYCEQFKVYALDDGKTYF------LKSVKIDAESLTEFTNEK 126 Query: 406 SCLQSSRENSHLVTFYGSESHRGHL--FVCVTLCEQTLEACLDVHRGEDVENEEDEFARN 463 L G+ + ++ T + + +V + Sbjct: 127 DTLSKLG------RLVGTFFNEQTQVHYILTTFIKGIDLSRYKNALPLNVNLKHFWEVLG 180 Query: 464 VLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 ++ S+ V++ H G H+DL+P NI++D+ HL DF S Sbjct: 181 IMISVCHQVKQFHE-LGLIHRDLKPGNIMLDADMQCHLVDFGSS 223 >6DJS-A nrPDB Length = 676 Score = 55.9 bits (133), Expect = 6e-08, Method: Composition-based stats. Identities = 37/179 (20%), Positives = 62/179 (34%), Gaps = 37/179 (20%) Query: 1 MESRDHNNPQEGPT---SSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLE--GGANVNFQE 55 M + GP + G E+ L A + ++ +V+++LE NVN + Sbjct: 18 MREKGRRQAVRGPAFMFNDRGTSLTAEEERFL-DAAEYGNIPVVRKMLEESKTLNVNCVD 76 Query: 56 EEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKG 115 G L AV ++ ELLL+ + G +LA G V++++ L+ Sbjct: 77 YMG-QNALQLAVGNEHLEVTELLLKK----ENLARIGD-ALLLAISKGYVRIVEAILNHP 130 Query: 116 A-------------------DVNECDFYGF------TAFMEAAVYGKVKALKFLYKRGA 149 D D G T + AA K + + L +GA Sbjct: 131 GFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGA 189 Score = 52.4 bits (124), Expect = 7e-07, Method: Composition-based stats. Identities = 40/175 (22%), Positives = 66/175 (37%), Gaps = 42/175 (24%) Query: 96 FILAAIAGSVKLLKLFL--SKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNL 153 F+ AA G++ +++ L SK +VN D+ G A A ++ + L K Sbjct: 48 FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLK------- 100 Query: 154 RRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSS 213 +E L + G AL+ A KG+V +++ +L+ G +S Sbjct: 101 -------KENLARIGD-ALLLAISKGYVRIVEAILNHPG-----------------FAAS 135 Query: 214 DDSDVEAITHLLLDHGADVNVRGERGK------TPLILAVEKKHLGLVQRLLEQE 262 + L D D E G TP+ILA + +V LL + Sbjct: 136 KRLTLSPCEQELQDD--DFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKG 188 Score = 50.1 bits (118), Expect = 4e-06, Method: Composition-based stats. Identities = 23/79 (29%), Positives = 44/79 (55%), Gaps = 1/79 (1%) Query: 246 AVEKKHLGLVQRLLEQ-EHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDL 304 A E ++ +V+++LE+ + + +N D G+ AL LAV + ++ ELL K+ GD Sbjct: 51 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDA 110 Query: 305 VMTARRNYDHSLVKVLLSH 323 ++ A +V+ +L+H Sbjct: 111 LLLAISKGYVRIVEAILNH 129 Score = 48.2 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 36/153 (23%), Positives = 66/153 (43%), Gaps = 34/153 (22%) Query: 173 MDAAEKGHVEVLKILLDEMGA-DVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 231 +DAAE G++ V++ +L+E +VN D MG+NAL A+ ++ +T LLL Sbjct: 49 LDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAV----GNEHLEVTELLLKKENL 104 Query: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHI------------------EINDTDSDG 273 + L+LA+ K ++ +V+ +L + D DG Sbjct: 105 ARIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDG 159 Query: 274 K------TALLLAVELKLKKIAELLCKRGASTD 300 T ++LA + ++ +L +GA + Sbjct: 160 TRFSPDITPIILAAHCQKYEVVHMLLMKGARIE 192 Score = 47.0 bits (110), Expect = 3e-05, Method: Composition-based stats. Identities = 22/143 (15%), Positives = 43/143 (30%), Gaps = 22/143 (15%) Query: 65 NAVQMSREDIVELLLRHGA--DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECD 122 +A + +V +L + G LA +++ +L L K D Sbjct: 50 DAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD 109 Query: 123 FYGFTAFMEAAVYGKVKALKFLYKR------------GANVNLRRKTKEDQERLR---KG 167 A + A G V+ ++ + L+ + Sbjct: 110 -----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSP 164 Query: 168 GATALMDAAEKGHVEVLKILLDE 190 T ++ AA EV+ +LL + Sbjct: 165 DITPIILAAHCQKYEVVHMLLMK 187 >6C8G-A nrPDB Length = 675 Score = 55.5 bits (132), Expect = 9e-08, Method: Composition-based stats. Identities = 30/156 (19%), Positives = 50/156 (32%), Gaps = 29/156 (18%) Query: 59 GWTPLHNAVQMSREDIVELLLRHGADPVLRKKN--------------GATPFILAAIAGS 104 G T LH A++ + VELL+ GAD + + G P LAA Sbjct: 103 GQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQ 162 Query: 105 VKLLKLFLSKG---ADVNECDFYGFTAFM-EAAVYGK--------VKALKFLYKRGANVN 152 ++ AD+ D G T A+ K L + + Sbjct: 163 PDIVHYLTENAHKKADIRRQDSRGNTVLHALVAIADNTRENTKFVTKVYDLLVIKCVKLY 222 Query: 153 LRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188 + + LM AA+ G + + + ++ Sbjct: 223 P---DSSLEAIFNNDSMSPLMMAAKLGKIGIFQHII 255 Score = 49.3 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 34/156 (21%), Positives = 55/156 (35%), Gaps = 31/156 (19%) Query: 154 RRKTKEDQERLRKGGATALMDAAEK---GHVEVLKILLD------EMGADVN--ACDNMG 202 +++ +++ R G T L A G + + +L+D + +N D Sbjct: 42 KKRLTDEEFREASTGKTCLTKALMNLNGGKNDTIPMLIDIAEKTGNLREFINSPFRDVYY 101 Query: 203 R-NALIHALLSSDDSDVEAITHLLLDHGADVNVRGE--------------RGKTPLILAV 247 R +H + LL++ GADV+ + G+ PL LA Sbjct: 102 RGQTALHIAIERRCKHY---VELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAA 158 Query: 248 EKKHLGLVQRLLEQEH--IEINDTDSDGKTALLLAV 281 +V L E H +I DS G T L V Sbjct: 159 CTNQPDIVHYLTENAHKKADIRRQDSRGNTVLHALV 194 Score = 41.2 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 33/137 (24%), Positives = 52/137 (37%), Gaps = 18/137 (13%) Query: 125 GFTAFMEAAVY---GKVKALKFLYKRGANV-NLRRKTKEDQERLRKGGATALMDAAEKGH 180 G T +A + GK + L NLR + G TAL A E+ Sbjct: 56 GKTCLTKALMNLNGGKNDTIPMLIDIAEKTGNLREFINSPFRDVYYRGQTALHIAIERRC 115 Query: 181 VEVLKILLDEMGADVNAC---------DNMGRNAL-IHALLSSDDSDVEAITHLLLDH-- 228 +++L+++ GADV+A D G L + ++ I H L ++ Sbjct: 116 KHYVELLVEK-GADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPDIVHYLTENAH 174 Query: 229 -GADVNVRGERGKTPLI 244 AD+ + RG T L Sbjct: 175 KKADIRRQDSRGNTVLH 191 Score = 38.1 bits (87), Expect = 0.015, Method: Composition-based stats. Identities = 12/30 (40%), Positives = 18/30 (60%) Query: 273 GKTALLLAVELKLKKIAELLCKRGASTDCG 302 G+TAL +A+E + K ELL ++GA Sbjct: 103 GQTALHIAIERRCKHYVELLVEKGADVHAQ 132 >6BBJ-A nrPDB Length = 868 Score = 55.5 bits (132), Expect = 9e-08, Method: Composition-based stats. Identities = 30/156 (19%), Positives = 50/156 (32%), Gaps = 29/156 (18%) Query: 59 GWTPLHNAVQMSREDIVELLLRHGADPVLRKKN--------------GATPFILAAIAGS 104 G T LH A++ + VELL+ GAD + + G P LAA Sbjct: 234 GQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQ 293 Query: 105 VKLLKLFLSKG---ADVNECDFYGFTAFM-EAAVYGK--------VKALKFLYKRGANVN 152 ++ AD+ D G T A+ K L + + Sbjct: 294 PDIVHYLTENAHKKADIRRQDSRGNTVLHALVAIADNTRENTKFVTKVYDLLVIKCVKLY 353 Query: 153 LRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188 + + LM AA+ G + + + ++ Sbjct: 354 P---DSSLEAIFNNDSMSPLMMAAKLGKIGIFQHII 386 Score = 49.3 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 34/156 (21%), Positives = 55/156 (35%), Gaps = 31/156 (19%) Query: 154 RRKTKEDQERLRKGGATALMDAAEK---GHVEVLKILLD------EMGADVN--ACDNMG 202 +++ +++ R G T L A G + + +L+D + +N D Sbjct: 173 KKRLTDEEFREASTGKTCLTKALMNLNGGKNDTIPMLIDIAEKTGNLREFINSPFRDVYY 232 Query: 203 R-NALIHALLSSDDSDVEAITHLLLDHGADVNVRGE--------------RGKTPLILAV 247 R +H + LL++ GADV+ + G+ PL LA Sbjct: 233 RGQTALHIAIERRCKHY---VELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAA 289 Query: 248 EKKHLGLVQRLLEQEH--IEINDTDSDGKTALLLAV 281 +V L E H +I DS G T L V Sbjct: 290 CTNQPDIVHYLTENAHKKADIRRQDSRGNTVLHALV 325 Score = 41.2 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 33/137 (24%), Positives = 52/137 (37%), Gaps = 18/137 (13%) Query: 125 GFTAFMEAAVY---GKVKALKFLYKRGANV-NLRRKTKEDQERLRKGGATALMDAAEKGH 180 G T +A + GK + L NLR + G TAL A E+ Sbjct: 187 GKTCLTKALMNLNGGKNDTIPMLIDIAEKTGNLREFINSPFRDVYYRGQTALHIAIERRC 246 Query: 181 VEVLKILLDEMGADVNAC---------DNMGRNAL-IHALLSSDDSDVEAITHLLLDH-- 228 +++L+++ GADV+A D G L + ++ I H L ++ Sbjct: 247 KHYVELLVEK-GADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPDIVHYLTENAH 305 Query: 229 -GADVNVRGERGKTPLI 244 AD+ + RG T L Sbjct: 306 KKADIRRQDSRGNTVLH 322 Score = 38.1 bits (87), Expect = 0.015, Method: Composition-based stats. Identities = 12/30 (40%), Positives = 18/30 (60%) Query: 273 GKTALLLAVELKLKKIAELLCKRGASTDCG 302 G+TAL +A+E + K ELL ++GA Sbjct: 234 GQTALHIAIERRCKHYVELLVEKGADVHAQ 263 >4JRN-A nrPDB Length = 372 Score = 55.5 bits (132), Expect = 9e-08, Method: Composition-based stats. Identities = 31/171 (18%), Positives = 48/171 (28%), Gaps = 27/171 (15%) Query: 430 LFVCVTLCEQTLEACLDVHRGEDVENEED--EFARNVLS-SIFKAVQELHLSCGYTHQDL 486 F+ + E + + G+ N+ + R LS K V + + G H D+ Sbjct: 170 YFLLMMRAEADMSKVISWVFGDASVNKSEFGLVVRMYLSSQAIKLVANV-QAQGIVHTDI 228 Query: 487 QPQNILIDSKKAAHLADFDKSI------KWAGDP---------------QEVKRDLEDLG 525 +P N L+ L DF + G P D LG Sbjct: 229 KPANFLLLKDGRLFLGDFGTYRINNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLG 288 Query: 526 RLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEE-TKDLIHRLFHPGEHVRD 575 + LY + E +DLI L + R Sbjct: 289 -ITLYCIWCKERPTPADGIWDYLHFADCPSTPELVQDLIRSLLNRDPQKRM 338 >5C01-A nrPDB Length = 342 Score = 55.1 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 30/213 (14%), Positives = 55/213 (25%), Gaps = 37/213 (17%) Query: 404 EVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARN 463 E + L S ++HL +G + E LDV + + + Sbjct: 128 ETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGP---LDVWLRRERGHVPMAWKMV 184 Query: 464 VLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA-------AHLADFDKSIKWAGDPQE 516 V + A+ L + H ++ +NIL+ L+D + + Sbjct: 185 VAQQLASALSYL-ENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREER 243 Query: 517 VKR--------------------DLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQL--- 553 V+R D G +L + G + E Q Sbjct: 244 VERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHR 303 Query: 554 ---SPDEETKDLIHRLFHPGEHVRDCLSDLLGH 583 + L + R +L Sbjct: 304 LPEPSCPQLATLTSQCLTYEPTQRPSFRTILRD 336 >4WOV-A nrPDB Length = 317 Score = 54.7 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 30/213 (14%), Positives = 55/213 (25%), Gaps = 37/213 (17%) Query: 404 EVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARN 463 E + L S ++HL +G + E LDV + + + Sbjct: 105 ETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGP---LDVWLRRERGHVPMAWKMV 161 Query: 464 VLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA-------AHLADFDKSIKWAGDPQE 516 V + A+ L + H ++ +NIL+ L+D + + Sbjct: 162 VAQQLASALSYL-ENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREER 220 Query: 517 VKR--------------------DLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQL--- 553 V+R D G +L + G + E Q Sbjct: 221 VERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHR 280 Query: 554 ---SPDEETKDLIHRLFHPGEHVRDCLSDLLGH 583 + L + R +L Sbjct: 281 LPEPSCPQLATLTSQCLTYEPTQRPSFRTILRD 313 >5USZ-A nrPDB Length = 289 Score = 52.4 bits (124), Expect = 7e-07, Method: Composition-based stats. Identities = 37/267 (13%), Positives = 75/267 (28%), Gaps = 53/267 (19%) Query: 366 DEKYKIADTSEGGIYLGFYE-------------KQEVAVKTFCEGSPRAQR---EVSCLQ 409 +E ++ G + ++ + EV +K + E + + Sbjct: 7 NEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMM 66 Query: 410 SSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIF 469 S + HLV YG + + LD + ++ + V + Sbjct: 67 SKLSHKHLVLNYGVCVCGDENILVQEFVKFGS---LDTYLKKNKNCINILWKLEVAKQLA 123 Query: 470 KAVQELHLSCGYTHQDLQPQNILI----DSKKA----AHLADFDKSIK-----------W 510 A+ L + H ++ +NIL+ D K L+D SI Sbjct: 124 AAMHFLEENT-LIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIP 182 Query: 511 AGDPQEVK--------RDLEDLGRLVLYVVKKGSISFEDLKAQSNEE------VVQLSPD 556 P+ ++ D G + + G L +Q + + Sbjct: 183 WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKA 242 Query: 557 EETKDLIHRLFHPGEHVRDCLSDLLGH 583 E +LI+ R ++ Sbjct: 243 AELANLINNCMDYEPDHRPSFRAIIRD 269 >4I94-A nrPDB Length = 300 Score = 50.9 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 44/245 (17%), Positives = 70/245 (28%), Gaps = 38/245 (15%) Query: 372 ADTSEGGIYLGFYEKQE-VAVKTFCE----GSPRAQREVSCLQSSRENSHLVTFYGSESH 426 + + +Y G E Q +AVK F S + E + R + Sbjct: 38 GERAPNVVYKGKLENQRRIAVKRFNRKSWPDSRQFLEEAKAVGQLRNHRMANLLGCCYED 97 Query: 427 RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDL 486 L + + +TL L + ++ V I +A++ + DL Sbjct: 98 EERLLIAEFMPNETLAKHLFHWESQPMKW---AMRLRVALHIAQALEYCTSKGRALYHDL 154 Query: 487 QPQNILIDSKKAAHLADFDK----------SIKWAGDPQEVKRD--------LEDLGRLV 528 +L D L+ F S A P E R + G L+ Sbjct: 155 NAYRVLFDDDANPRLSCFGLMKNSRDGKSYSTNLAFTPPEYLRTGRVTPESVIYSFGTLL 214 Query: 529 LYVVKKGSISFE---DLKAQSNEE-------VVQLSPDE--ETKDLIHRLFHPGEHVRDC 576 L ++ I DL N + Q S D+ E L R R Sbjct: 215 LDLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRERPN 274 Query: 577 LSDLL 581 L+ Sbjct: 275 PKSLV 279 >6G1K-A nrPDB Length = 921 Score = 48.9 bits (115), Expect = 8e-06, Method: Composition-based stats. Identities = 33/93 (35%), Positives = 47/93 (50%), Gaps = 8/93 (8%) Query: 246 AVEKKHLGLVQRLLEQEHI----EINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC 301 AVEK V+ LE+ I IN D G+TALL+A+E + +I ELL + Sbjct: 39 AVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAIENENLEIIELLLSF--NVYV 96 Query: 302 GDLVMTARRNYDHSLVKVLLSHG--AKEDFHPP 332 GD ++ A R V++LL+H + E PP Sbjct: 97 GDALLHAIRKEVVGAVELLLNHKKPSGEKQVPP 129 Score = 47.4 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 25/133 (18%), Positives = 50/133 (37%), Gaps = 15/133 (11%) Query: 66 AVQMSREDIVELLLRHGA-----DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNE 120 AV+ V+L L + G T ++A ++++++L LS +V Sbjct: 39 AVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAIENENLEIIELLLS--FNVYV 96 Query: 121 CDFYGFTAFMEAAVYGKVKALKFLYKR---GANVNLRRKTKEDQERLRKGGATALMDAAE 177 D A + A V A++ L + + Q T ++ AA Sbjct: 97 GD-----ALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSDFTPDITPIILAAH 151 Query: 178 KGHVEVLKILLDE 190 + E++K+L+ + Sbjct: 152 TNNYEIIKMLVQK 164 Score = 44.7 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 30/144 (20%), Positives = 58/144 (40%), Gaps = 30/144 (20%) Query: 132 AAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEM 191 A G ++K + K + + G TAL+ A E ++E++++LL Sbjct: 39 AVEKGDYASVKLALE-----EAEIYFKININCIDPLGRTALLIAIENENLEIIELLLSF- 92 Query: 192 GADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHG-------ADVNVRGERGK---- 240 +V D AL+HA+ +V LLL+H + ++ Sbjct: 93 --NVYVGD-----ALLHAI----RKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSDFTP 141 Query: 241 --TPLILAVEKKHLGLVQRLLEQE 262 TP+ILA + +++ L+++ Sbjct: 142 DITPIILAAHTNNYEIIKMLVQKG 165 Score = 42.0 bits (97), Expect = 9e-04, Method: Composition-based stats. Identities = 36/141 (25%), Positives = 63/141 (44%), Gaps = 27/141 (19%) Query: 175 AAEKGHVEVLKILLDE----MGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGA 230 A EKG +K+ L+E ++N D +GR AL+ A+ +++ I LLL Sbjct: 39 AVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAI----ENENLEIIELLLSF-- 92 Query: 231 DVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIE---------INDTDSDGK---TALL 278 +V V L+ A+ K+ +G V+ LL + ++ SD T ++ Sbjct: 93 NVYVGD-----ALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSDFTPDITPII 147 Query: 279 LAVELKLKKIAELLCKRGAST 299 LA +I ++L ++G S Sbjct: 148 LAAHTNNYEIIKMLVQKGVSV 168 Score = 41.6 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 30/103 (29%), Positives = 48/103 (46%), Gaps = 21/103 (20%) Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHG------ 82 L+ A++NE++++++ LL V G LH A++ VELLL H Sbjct: 74 LLIAIENENLEIIELLLSFNVYV-------GDALLH-AIRKEVVGAVELLLNHKKPSGEK 125 Query: 83 -ADPVLRKKN------GATPFILAAIAGSVKLLKLFLSKGADV 118 P+L K TP ILAA + +++K+ + KG V Sbjct: 126 QVPPILLDKQFSDFTPDITPIILAAHTNNYEIIKMLVQKGVSV 168 Score = 40.5 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 30/146 (20%), Positives = 50/146 (34%), Gaps = 38/146 (26%) Query: 30 IKAVQNEDVDLVQQLLEG-----GANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGAD 84 + AV+ D V+ LE N+N + G T L A++ +I+ELLL + Sbjct: 37 LSAVEKGDYASVKLALEEAEIYFKININCID-PLGRTALLIAIENENLEIIELLLSF--N 93 Query: 85 PVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGF------------------ 126 + + A V ++L L N G Sbjct: 94 VYVGDA-----LLHAIRKEVVGAVELLL------NHKKPSGEKQVPPILLDKQFSDFTPD 142 Query: 127 -TAFMEAAVYGKVKALKFLYKRGANV 151 T + AA + +K L ++G +V Sbjct: 143 ITPIILAAHTNNYEIIKMLVQKGVSV 168 >5UU1-A nrPDB Length = 324 Score = 47.0 bits (110), Expect = 3e-05, Method: Composition-based stats. Identities = 26/168 (15%), Positives = 58/168 (34%), Gaps = 42/168 (25%) Query: 409 QSSRENSHLVTFYGS----ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNV 464 + + + FYGS R + F+ + L+ G++ ++ + Sbjct: 81 RKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQK----ISGQNGTFKKSTVLQLG 136 Query: 465 LSSIFKAVQELHLSCGYTHQDLQPQNILIDSKK--AAHLADFDKSIKWAGDPQEV----- 517 + + ++ +H + Y H D++ N+L+ K +LAD+ S ++ + Sbjct: 137 IR-MLDVLEYIHENE-YVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQEN 194 Query: 518 ------------------------KRDLEDLGRLVLYVVKKGSISFED 541 + D+E LG +L G + +E Sbjct: 195 PRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCML-RWLCGKLPWEQ 241 >6G4J-A nrPDB Length = 315 Score = 46.2 bits (108), Expect = 5e-05, Method: Composition-based stats. Identities = 27/153 (17%), Positives = 56/153 (36%), Gaps = 21/153 (13%) Query: 368 KYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHR 427 + ++ + G +YL VA+K + S EV+ L+S + VT S Sbjct: 31 RKQLGKGANGIVYLAETSDGHVALK-VSDDSLSITSEVNVLKSFSKAQS-VTMGPSFFDT 88 Query: 428 GHLFV----------CVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHL 477 ++ + + L + V ++ E+ ++ + ++ LH Sbjct: 89 DDAYIPSANTKVSFYAMEYIKGPL-------LLKYVSDKGAEWIPVLMIQLLSSLSVLHQ 141 Query: 478 SCGYTHQDLQPQNILIDSKKA-AHLADFDKSIK 509 G+ DL+P N+++ A D + K Sbjct: 142 -QGWIFGDLKPDNLIVTGPPARIRCIDVGGTTK 173 >4L68-A nrPDB Length = 340 Score = 45.5 bits (106), Expect = 9e-05, Method: Composition-based stats. Identities = 30/145 (20%), Positives = 44/145 (30%), Gaps = 12/145 (8%) Query: 371 IADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQRE----VSCLQSSRENSHLVTFYGSESH 426 I T G Y +RE ++ L R +S+L G Sbjct: 48 IVSTRTGTTYKALLPDGSALAVKHLSTCKLGEREFRYEMNQLWELR-HSNLAPLLGFCVV 106 Query: 427 RGHLFVCVTLCEQ-TLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG--YTH 483 F+ TL + LD +RGE + + LH C H Sbjct: 107 EEEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAAR----GLAWLHHGCRPPILH 162 Query: 484 QDLQPQNILIDSKKAAHLADFDKSI 508 Q++ ILID A + D + Sbjct: 163 QNICSSVILIDEDFDARIIDSGLAR 187 >4IX6-A nrPDB Length = 350 Score = 45.5 bits (106), Expect = 9e-05, Method: Composition-based stats. Identities = 25/182 (13%), Positives = 53/182 (29%), Gaps = 33/182 (18%) Query: 371 IADTSEGGIYLGFYE-KQEVAVKTFCEGSPRAQREVSCLQSSRENSHL------VTFYGS 423 + + G ++ G ++ Q+V +K A+ + C + H F G Sbjct: 28 LGSGNFGTVFRGVFKGDQDVVLKNAKADVMAAEELLECEMDVNYHVHANAKGTCARFMGC 87 Query: 424 ES----HRGHLF-------VCVTLCEQTLEACLDVHRGEDVEN---------EEDEFARN 463 G ++ + + + + R E + Sbjct: 88 IELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATELGVTKK 147 Query: 464 VLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK--KAAHLADFD---KSIKWAGDPQEVK 518 + + ++ LH CG H+D++P N++ K L D + Sbjct: 148 AMRELLGSLARLHE-CGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETLNYYP 206 Query: 519 RD 520 D Sbjct: 207 GD 208 >4CI6-B nrPDB Length = 643 Score = 44.7 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 27/166 (16%), Positives = 58/166 (34%), Gaps = 17/166 (10%) Query: 365 IDEKYKIADTSEGGIYLGFYEKQEVAVK---TFCEGSPRAQREV--SCLQSSRENSHLVT 419 + E K A+ + +KQ + K + EG A+ E +++ ++ +L Sbjct: 47 VAETDKFAEGESHISIIETKDKQRLVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLAN 106 Query: 420 FYGS----ESHRGHLFVCVT-----LCEQTLEACLDVHRGEDVENEEDEFA-RNVLSSIF 469 +G +R + + + C TL + D + + +E + + + Sbjct: 107 VHGMAVVPYGNRYYYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLL 166 Query: 470 KAVQELHLSCGYTHQDLQPQNILIDS-KKAAHLADFDKSIKWAGDP 514 L G H D++P N++ D + D + P Sbjct: 167 DVTNHL-AKAGIVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQP 211 >5UV4-A nrPDB Length = 311 Score = 44.7 bits (104), Expect = 2e-04, Method: Composition-based stats. Identities = 28/147 (19%), Positives = 53/147 (36%), Gaps = 10/147 (6%) Query: 371 IADTSEGGIYLGFYEKQEVA-VKTFCEGSPRAQ----REVSCLQSSRENSHLVTFYGSE- 424 I + G Y + + VK EG +++ RE+ L S R + +LV G Sbjct: 33 IGRSCHGTSYKATLDNGYMLTVKWLKEGFAKSKKEFSREIKKLGSVR-HPNLVPLRGYYW 91 Query: 425 --SHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYT 482 + + +L L ++ N+ I + + LH Sbjct: 92 GPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNERVIP 151 Query: 483 HQDLQPQNILI-DSKKAAHLADFDKSI 508 H +++ N+LI +S +A + D+ Sbjct: 152 HGNIKSSNVLIQNSTPSALVTDYSLHR 178 >3ENH-A nrPDB Length = 540 Score = 43.5 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 42/254 (16%), Positives = 94/254 (37%), Gaps = 38/254 (14%) Query: 297 ASTDCGDLVMTARRNYDHSLVKVL--LSHGAKEDFHPPAEDWKPQSSH---WGAALKDLH 351 A T+ G++++ ++ L ++L + G DF+ P +++ + W L + Sbjct: 245 AHTNKGEVMLVGGVAANNRLREMLKAMCEGQNVDFYVPPKEFCGDNGAMIAWLGLLMHKN 304 Query: 352 RIYRPMIGKLKFFID---------------------EKYKIADTSEGGIYLGFYEKQEVA 390 + + + K + ++ I +E I Y +V Sbjct: 305 GRWMSL-DETKIIPNYRTDMVEVNWIKEIKGKKRKIPEHLIGKGAEADIKRDSYLDFDVI 363 Query: 391 VKTFCEGSPRAQR---EVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDV 447 +K + R +R + +++RE +L ++F ++ + + ++ Sbjct: 364 IKERVKKGYRDERLDENIRKSRTAREARYLALVKDFGIPAPYIFDVDLDNKRIMMSYING 423 Query: 448 HRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 507 +DV + + A I + V +LH + H DL N + D K ++ DF Sbjct: 424 KLAKDVIEDNLDIA----YKIGEIVGKLHKN-DVIHNDLTTSNFIFD--KDLYIIDFGLG 476 Query: 508 IKWAGDPQEVKRDL 521 K + ++ DL Sbjct: 477 -KISNLDEDKAVDL 489 >3REP-A nrPDB Length = 271 Score = 43.5 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 34/246 (13%), Positives = 75/246 (30%), Gaps = 42/246 (17%) Query: 370 KIADTSEGGIYLGFYEKQEVAVK--TFCEGSPRAQR----EVSCLQSSRENSHLVTFYGS 423 K+ + G ++ G ++ ++ VK + S R R E L+ + +++ G+ Sbjct: 17 KLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFS-HPNVLPVLGA 75 Query: 424 ESHRGHLF--VCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 + +H G + ++ + + L + + + LH Sbjct: 76 CQSPPAPHPTLITHWMPYG-SLYNVLHEGTNFVVDQSQAVKFAL-DMARGMAFLHTLEPL 133 Query: 482 THQD-LQPQNILIDSKKAAHL--ADFDKSIKWAG------------------DPQEVKRD 520 + L ++++ID A + AD S + G D D Sbjct: 134 IPRHALNSRSVMIDEDMTARISMADVKFSFQSPGRMYAPAWVAPEALQKKPEDTNRRSAD 193 Query: 521 LEDLGRLVLYVVKKGSISFEDL-------KAQSNEEVVQLSP--DEETKDLIHRLFHPGE 571 + ++L+ + + F DL K + P L+ + Sbjct: 194 MWSF-AVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVSKLMKICMNEDP 252 Query: 572 HVRDCL 577 R Sbjct: 253 AKRPKF 258 >4CJ9-A nrPDB Length = 794 Score = 43.2 bits (100), Expect = 4e-04, Method: Composition-based stats. Identities = 48/214 (22%), Positives = 75/214 (35%), Gaps = 39/214 (18%) Query: 15 SSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGAN----VNFQEEEGGWTPL-----HN 65 + + A + + AV +DL + L E G + VN GG L H Sbjct: 547 ADIVKIAGNDGGTQALHAV----LDLERMLGERGFSRADIVNVAGNNGGAQALKAVLEHE 602 Query: 66 AV----QMSREDIVEL------------LLRHGADPVLRKKNGATPFILAAIAGSVKLLK 109 A SR DIV++ +L H A R + A +A G + LK Sbjct: 603 ATLNERGFSRADIVKIAGNGGGAQALKAVLEHEATLDERGFSRADIVRIAGNGGGAQALK 662 Query: 110 LFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGG- 168 L G +NE F AA G +ALK + + G + R + D + G Sbjct: 663 AVLEHGPTLNERGFNLTDIVEMAANSGGAQALKAVLEHGPTLRQRGLSLIDIVEIASNGG 722 Query: 169 ---------ATALMDAAEKGHVEVLKILLDEMGA 193 ++ A + + E++ + GA Sbjct: 723 AQALKAVLKYGPVLMQAGRSNEEIVHVAARRGGA 756 >4AZV-A nrPDB Length = 569 Score = 42.8 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 16/89 (17%), Positives = 39/89 (43%), Gaps = 8/89 (8%) Query: 425 SHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQ 484 + ++ + L + + + E+ +L S+ +++ L G+ H Sbjct: 312 ENAQSGWLVMEKLPGRLLSDM-------LAAGEEIDREKILGSLLRSLAAL-EKQGFWHD 363 Query: 485 DLQPQNILIDSKKAAHLADFDKSIKWAGD 513 D++P N+++D+++ A L DF + D Sbjct: 364 DVRPWNVMVDARQHARLIDFGSIVTTPQD 392 >4AZW-A nrPDB Length = 471 Score = 42.4 bits (98), Expect = 7e-04, Method: Composition-based stats. Identities = 16/89 (17%), Positives = 39/89 (43%), Gaps = 8/89 (8%) Query: 425 SHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQ 484 + ++ + L + + + E+ +L S+ +++ L G+ H Sbjct: 312 ENAQSGWLVMEKLPGRLLSDM-------LAAGEEIDREKILGSLLRSLAAL-EKKGFWHD 363 Query: 485 DLQPQNILIDSKKAAHLADFDKSIKWAGD 513 D++P N+++D+++ A L DF + D Sbjct: 364 DVRPWNVMVDARQHARLIDFGSIVTTPQD 392 >2RSV-A nrPDB Length = 403 Score = 41.6 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 13/87 (14%), Positives = 34/87 (39%), Gaps = 7/87 (8%) Query: 427 RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDL 486 + + F+ + L+ ++ + L I ++ +H Y H D+ Sbjct: 131 KSYRFMIMDRFGSDLQK---IYEANAKRFSRKTVLQLSLR-ILDILEYIHE-HEYVHGDI 185 Query: 487 QPQNILIDSKK--AAHLADFDKSIKWA 511 + N+L++ K +L D+ + ++ Sbjct: 186 KASNLLLNYKNPDQVYLVDYGLAYRYC 212 >2LAV-A nrPDB Length = 361 Score = 41.2 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 13/87 (14%), Positives = 34/87 (39%), Gaps = 7/87 (8%) Query: 427 RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDL 486 + + F+ + L+ ++ + L I ++ +H Y H D+ Sbjct: 124 KSYRFMIMDRFGSDLQK---IYEANAKRFSRKTVLQLSLR-ILDILEYIHE-HEYVHGDI 178 Query: 487 QPQNILIDSKK--AAHLADFDKSIKWA 511 + N+L++ K +L D+ + ++ Sbjct: 179 KASNLLLNYKNPDQVYLVDYGLAYRYC 205 >2JII-A nrPDB Length = 352 Score = 38.5 bits (88), Expect = 0.011, Method: Composition-based stats. Identities = 39/224 (17%), Positives = 75/224 (33%), Gaps = 57/224 (25%) Query: 426 HRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQD 485 + F+ + ++L++ LDV + + V + A++ LH + Y H + Sbjct: 129 QDKYRFLVLPSLGRSLQSALDVSPKHVL---SERSVLQVACRLLDALEFLHENE-YVHGN 184 Query: 486 LQPQNILID--SKKAAHLADFDKSIKWA-----------------GDPQEV--------- 517 + +NI +D + LA + + ++ GD + + Sbjct: 185 VTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCG 244 Query: 518 ---KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLF--HPGEH 572 + DL+ LG +L G + P+ E + F PG Sbjct: 245 PSRRSDLQSLGYCML-KWLYGFLP-----------WTNCLPNTEDIMKQKQKFVDKPGPF 292 Query: 573 VRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILR 616 V C GH + E+ + L+ V + K +LR Sbjct: 293 VGPC-----GH-WIRPSETLQKYLKVV--MALTYEEKPPYAMLR 328 >5Z96-A nrPDB Length = 755 Score = 36.6 bits (83), Expect = 0.039, Method: Composition-based stats. Identities = 23/69 (33%), Positives = 31/69 (44%), Gaps = 14/69 (20%) Query: 63 LHNAVQMSREDIVELLLRHG-------ADPVLRKKN------GATPFILAAIAGSVKLLK 109 LH A++ VELLL H P+L K TP ILAA + +++K Sbjct: 101 LH-AIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIK 159 Query: 110 LFLSKGADV 118 L + KG V Sbjct: 160 LLVQKGVSV 168 Score = 36.2 bits (82), Expect = 0.055, Method: Composition-based stats. Identities = 41/178 (23%), Positives = 72/178 (40%), Gaps = 30/178 (16%) Query: 141 LKFLYKRGANVNLRRKTKED---QERLRKGGATALMDAAEKGHVEVLKILLDE----MGA 193 +F YKR N R + E A ++A EKG +K L+E Sbjct: 2 AQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKI 61 Query: 194 DVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLG 253 ++N D +GR AL+ A+ + + +E + +V V L+ A+ K+ +G Sbjct: 62 NINCIDPLGRTALLIAIENENLELIELLLSF------NVYVGD-----ALLHAIRKEVVG 110 Query: 254 LVQRLLEQEHIE---------INDTDSDGK---TALLLAVELKLKKIAELLCKRGAST 299 V+ LL + ++ S+ T ++LA +I +LL ++G S Sbjct: 111 AVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSV 168 Score = 30.1 bits (66), Expect = 3.3, Method: Composition-based stats. Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 8/93 (8%) Query: 246 AVEKKHLGLVQRLLEQEHI----EINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC 301 AVEK V++ LE+ I IN D G+TALL+A+E + ++ ELL + Sbjct: 39 AVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSF--NVYV 96 Query: 302 GDLVMTARRNYDHSLVKVLLSHG--AKEDFHPP 332 GD ++ A R V++LL+H + E PP Sbjct: 97 GDALLHAIRKEVVGAVELLLNHKKPSGEKQVPP 129 Score = 29.3 bits (64), Expect = 6.4, Method: Composition-based stats. Identities = 7/25 (28%), Positives = 13/25 (52%) Query: 127 TAFMEAAVYGKVKALKFLYKRGANV 151 T + AA + +K L ++G +V Sbjct: 144 TPIILAAHTNNYEIIKLLVQKGVSV 168 >6M7Z-A nrPDB Length = 319 Score = 35.4 bits (80), Expect = 0.084, Method: Composition-based stats. Identities = 22/157 (14%), Positives = 50/157 (31%), Gaps = 39/157 (24%) Query: 462 RNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLAD-----------------F 504 + + +++ A++ LH + G H+ ++ + + L F Sbjct: 147 QVLAANMVAALKSLH-NLGLLHRSIELNSFSVLPDGTVVLGGLDTAAPIGTETRLWVGFF 205 Query: 505 DKSIKWAGDPQ------------EVKRDLEDLGRLV---LYVVKKGSISFEDLKAQSNEE 549 + D VK D+ LG + ++ G++ ED A + Sbjct: 206 GQETAPEIDRNFLADLALTQGRHTVKSDVYSLGVAFRNLVQLLGNGNLGPEDRGAVRQDH 265 Query: 550 VVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 586 + E L ++ R + +++ P F Sbjct: 266 L------ELLDKLSQKMIEEEPGNRPTIEEIMKDPLF 296 >6G38-A nrPDB Length = 357 Score = 34.7 bits (78), Expect = 0.15, Method: Composition-based stats. Identities = 9/68 (13%), Positives = 24/68 (35%), Gaps = 5/68 (7%) Query: 424 ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTH 483 LF+ + ++ + + A+++L + ++ S + H Sbjct: 152 FFKDDQLFIVLEFEFGGIDLEQMRTKLSSLAT-----AKSILHQLTASLAVAEASLRFEH 206 Query: 484 QDLQPQNI 491 +DL N+ Sbjct: 207 RDLHWGNV 214 >6EAS-A nrPDB Length = 308 Score = 34.7 bits (78), Expect = 0.16, Method: Composition-based stats. Identities = 36/260 (13%), Positives = 78/260 (30%), Gaps = 46/260 (17%) Query: 357 MIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSH 416 +IG + K ++ E + + K E + +++++ L + + Sbjct: 47 IIGSTSTCMLYKGTLSSGVEIAVASSLVTSAKDWSK---ENESQYRKKITNLSKVS-HKN 102 Query: 417 LVTF--YGSESHRGHLFVCVTLCEQ-TLEACLDVHRGEDVENEEDEFARNVLSS-IFKAV 472 + Y E H + TL L V E + D AR +S I + Sbjct: 103 FMNLLGYCEEEHPFTRVMVFEYAPNGTLFEHLHVREAEKL----DWMARLRISMGIAYCL 158 Query: 473 QELHLSCG-YTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQE------VKRDLEDL- 524 + +H ++ + + AA ++D + G D+ED+ Sbjct: 159 EHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDLEFWNDAKGHNSTTNNELAFSPDMEDIV 218 Query: 525 ---GRLVLYVVKKGSISFEDLKAQSNEEVVQ------------------LSPDEETKDL- 562 G ++L + G + + E V P++ + L Sbjct: 219 RKYGMVLL-EILTGRVPSSEDD-GPLENWVSRYFEGGMRLEELIDPSIGFFPEDTARALC 276 Query: 563 --IHRLFHPGEHVRDCLSDL 580 + R + ++ Sbjct: 277 EVVRSCIDRDPKKRPQMKEV 296 >6EWX-A nrPDB Length = 484 Score = 34.7 bits (78), Expect = 0.17, Method: Composition-based stats. Identities = 8/31 (25%), Positives = 16/31 (51%), Gaps = 1/31 (3%) Query: 463 NVLSSIFKAVQELHLSCGYTHQDLQPQNILI 493 +L + ++ L G H+DL +N+L+ Sbjct: 214 FLLLQLCNGLEHLKE-HGIIHRDLCLENLLL 243 Score = 30.1 bits (66), Expect = 4.1, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 24/77 (31%), Gaps = 10/77 (12%) Query: 515 QEVKRDLEDLGRLVLYVVKKGSISFE--------DLKAQSNEEVVQLSP-DEETKDLIHR 565 Q K D G +++Y + FE D + + + LS + L H Sbjct: 326 QYRKFDEFQTG-ILIYELLHQPNPFEVRAQLRERDYRREDLPPLPTLSLYSPGLQQLAHL 384 Query: 566 LFHPGEHVRDCLSDLLG 582 L R + + Sbjct: 385 LLEADPIKRIRIGEAKR 401 >5VE6-A nrPDB Length = 492 Score = 34.3 bits (77), Expect = 0.18, Method: Composition-based stats. Identities = 8/43 (18%), Positives = 18/43 (41%), Gaps = 1/43 (2%) Query: 451 EDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILI 493 + + +L + ++ L G H+DL +N+L+ Sbjct: 200 QAEPEAYERRVCFLLLQLCNGLEHLKE-HGIIHRDLCLENLLL 241 Score = 29.3 bits (64), Expect = 7.0, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 24/77 (31%), Gaps = 10/77 (12%) Query: 515 QEVKRDLEDLGRLVLYVVKKGSISFE--------DLKAQSNEEVVQLSP-DEETKDLIHR 565 Q K D G +++Y + FE D + + + LS + L H Sbjct: 334 QYRKFDEFQTG-ILIYELLHQPNPFEVRAQLRERDYRQEDLPPLPALSLYSPGLQQLAHL 392 Query: 566 LFHPGEHVRDCLSDLLG 582 L R + + Sbjct: 393 LLEADPIKRIRIGEAKR 409 >4R10-A nrPDB Length = 572 Score = 33.9 bits (76), Expect = 0.25, Method: Composition-based stats. Identities = 21/102 (20%), Positives = 39/102 (38%), Gaps = 2/102 (1%) Query: 129 FMEAAVYGKVKALKFLY--KRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKI 186 F A + ++ L + +NVN+RR + + L+ G E++++ Sbjct: 63 FFNAPGFDHRSFVEALMAASKSSNVNVRRNAIGALSHMSEQRGGPLLIFRSGGLAEIIRM 122 Query: 187 LLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDH 228 L D + + V+ RN L+H S + L H Sbjct: 123 LYDSLESVVHYAVTTLRNLLMHVSDSRAQARALNAVEALTPH 164 >3BYV-A nrPDB Length = 377 Score = 33.9 bits (76), Expect = 0.27, Method: Composition-based stats. Identities = 23/161 (14%), Positives = 49/161 (30%), Gaps = 38/161 (23%) Query: 467 SIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAG----------DPQE 516 + + + LH G H L+P +I++D + L F+ ++ +P E Sbjct: 214 QVIRLLASLHH-YGLVHTYLRPVDIVLDQRGGVFLTGFEHLVRDGARVVSSVSRGFEPPE 272 Query: 517 VKR-------------------DLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLS--- 554 ++ D LG ++ ++ + A E + S Sbjct: 273 LEARRATISYHRDRRTLMTFSFDAWALGLVIYWIW-CADLPITKDAALGGSEWIFRSCKN 331 Query: 555 PDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRT 595 + + L+ + R + P + RT Sbjct: 332 IPQPVRALLEGFLRYPKEDRLLPLQAMETP----EYEQLRT 368 >5DMZ-A nrPDB Length = 365 Score = 33.9 bits (76), Expect = 0.27, Method: Composition-based stats. Identities = 18/121 (14%), Positives = 42/121 (34%), Gaps = 12/121 (9%) Query: 405 VSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNV 464 + L+ S ++ + + G + V TL +++++ + + Sbjct: 118 MERLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISF 177 Query: 465 LSSIFKAVQELHLSCGYTHQDLQPQNILI-----------DSKKAAHLADFDKSIKWAGD 513 + ++++H C H D++P N ++ D L D +SI Sbjct: 178 AMRMLYMIEQVH-DCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLF 236 Query: 514 P 514 P Sbjct: 237 P 237 >6G18-v nrPDB Length = 552 Score = 33.1 bits (74), Expect = 0.44, Method: Composition-based stats. Identities = 55/341 (16%), Positives = 103/341 (30%), Gaps = 59/341 (17%) Query: 383 FYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLE 442 Y + A+K F +R+ + N H V + L Sbjct: 151 LYLSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAV--------------VMELINGYPL 196 Query: 443 ACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLA 502 +H ED + DE + I K G H D N+++D + Sbjct: 197 C--QIHHVEDPASVYDEA----MELIVKLANH-----GLIHGDFNEFNLILDESDHITMI 245 Query: 503 DFDKSIKWAGDPQ---EVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEET 559 DF + + + P RD++ + + S F K E+ + + Sbjct: 246 DFPQMVSTS-HPNAEWYFDRDVKCIKDFFMKRFSYESELFPTFKDIRREDTLDVEVSAS- 303 Query: 560 KDLIHRLFHPGEHVRDCLSDLLGHPF------FWTWESRYRTLRN--VGNESDIKTRKSE 611 G D L HP T E + + V ++++ ++E Sbjct: 304 ----------GYTKEMQADDELLHPLGPDDKNIETKEGSEFSFSDGEVAEKAEVYGSENE 353 Query: 612 SEILRLLQPGPSEHSKSFDKWTTKIN----------ECVMKKMN-KFYEKRGNFYQNTVG 660 SE L + S D K + M + N E +G +N Sbjct: 354 SERNCLEESEGCYCRSSGDPEQIKEDSLSEESADARSFEMTEFNQALEEIKGQVVENNSV 413 Query: 661 DLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFPDLVI 701 +N E+ + + ++++ + S ++ P L+ Sbjct: 414 TEFSEEKNRTENYNRQDGQRVQGGVPAGSDEYEDECPHLIA 454 >1R71-A nrPDB Length = 178 Score = 32.8 bits (73), Expect = 0.51, Method: Composition-based stats. Identities = 21/118 (17%), Positives = 45/118 (38%), Gaps = 5/118 (4%) Query: 540 EDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHP-FFWTWESRYRTLRN 598 E + N + +L+P E D I R G+ D ++ P F + Sbjct: 23 EADQVIENLQRNELTPREIA-DFIGRELAKGKKKGDIAKEIGKSPAFITQHVTLLDLPEK 81 Query: 599 VGNESD---IKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGN 653 + + + ++ +E++ + P E D T +I +K + +F +++G Sbjct: 82 IADAFNTGRVRDVTVVNELVTAFKKRPEEVEAWLDDDTQEITRGTVKLLREFLDEKGR 139 >3DZO-A nrPDB Length = 413 Score = 32.0 bits (71), Expect = 0.88, Method: Composition-based stats. Identities = 28/200 (14%), Positives = 56/200 (28%), Gaps = 44/200 (22%) Query: 467 SIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD-----------PQ 515 + + + LH G H L+P +I++D + L F+ ++ P+ Sbjct: 219 QVIRLLASLHH-YGLVHTYLRPVDIVLDQRGGVFLTGFEHLVRDGASAVSPIGRGFAPPE 277 Query: 516 EVKR-----------------DLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLS---P 555 D LG + ++ + D A E + S Sbjct: 278 TTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIW-CADLPNTDDAALGGSEWIFRSCKNI 336 Query: 556 DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRT-------LRNVGNESDIKTR 608 + + L+ + R + P + RT L E + Sbjct: 337 PQPVRALLEGFLRYPKEDRLLPLQAMETP----EYEQLRTELSAALPLYQTDGEPTREGG 392 Query: 609 KSESEILRLLQPGPSEHSKS 628 S + + G +E + Sbjct: 393 APPSGTSQPDEAGAAEAVTA 412 >1TQM-A nrPDB Length = 282 Score = 31.6 bits (70), Expect = 1.4, Method: Composition-based stats. Identities = 42/193 (21%), Positives = 74/193 (38%), Gaps = 28/193 (14%) Query: 344 GAALKDLHRIYRP----MIGKLKFFIDEK--YKIADTSEGGIYLGFYEKQEVAVKTFCEG 397 G +L LHR+ R IGKL E + G + F++ + K E Sbjct: 76 GLSLYSLHRLVRSGKVDAIGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEK 135 Query: 398 SPRAQREVSCL--QSSR-ENSHLVTFYGSESHRGHLF----VCVTLCEQTLEACLDVHRG 450 S L +S+R E L G + + + V + L + +++R Sbjct: 136 RDYGDLHFSVLAIRSARNEFRALQKLQGLAVPKVYAWEGNAVLMELIDAK-----ELYRV 190 Query: 451 EDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKW 510 +E VL I + V + + G H DL N+L+ + + DF +S++ Sbjct: 191 RVENPDE------VLDMILEEVAKFYH-RGIVHGDLSQYNVLVSEEG-IWIIDFPQSVEV 242 Query: 511 A--GDPQEVKRDL 521 G + ++RD+ Sbjct: 243 GEEGWREILERDV 255 >4R0V-A nrPDB Length = 514 Score = 31.2 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 16/91 (17%), Positives = 26/91 (28%), Gaps = 2/91 (2%) Query: 349 DLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCL 408 I + G+ K+ E GG G + A+ + + E S L Sbjct: 395 AKKLITKMQAGEAKYDFVEIMACPAGCVGGG--GQPRSTDKAITQKRQAALYNLDEKSTL 452 Query: 409 QSSRENSHLVTFYGSESHRGHLFVCVTLCEQ 439 + S EN + Y + L Sbjct: 453 RRSHENPSIRELYDTYLGEPLGHKAHELLHT 483 >3PDI-A nrPDB Length = 483 Score = 30.8 bits (68), Expect = 2.0, Method: Composition-based stats. Identities = 9/50 (18%), Positives = 17/50 (34%) Query: 498 AAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSN 547 + D + E + D+ G +Y KG + F D+ + Sbjct: 381 DVKMLDEGNARVLLKTVDEYQADILIAGGRNMYTALKGRVPFLDINQERE 430 >2DI3-A nrPDB Length = 239 Score = 30.4 bits (67), Expect = 2.6, Method: Composition-based stats. Identities = 11/30 (36%), Positives = 15/30 (50%) Query: 59 GWTPLHNAVQMSREDIVELLLRHGADPVLR 88 GW LH++ + D+ E LL DP L Sbjct: 107 GWAALHSSAERGDWDVAEALLEKMDDPSLP 136 >6DFL-A nrPDB Length = 259 Score = 30.4 bits (67), Expect = 2.8, Method: Composition-based stats. Identities = 17/87 (19%), Positives = 36/87 (41%), Gaps = 2/87 (2%) Query: 422 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 481 GS+ R H F+ T++ + + R ++ ++ + V ++H + G Sbjct: 102 GSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPP-RLKRALVEAVARMVGDMHRA-GV 159 Query: 482 THQDLQPQNILIDSKKAAHLADFDKSI 508 H+D + L+ + K DF S+ Sbjct: 160 NHRDCYICHFLLHTDKPVSADDFRLSV 186 >4R7B-A nrPDB Length = 309 Score = 30.4 bits (67), Expect = 3.0, Method: Composition-based stats. Identities = 29/134 (21%), Positives = 49/134 (36%), Gaps = 12/134 (8%) Query: 435 TLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILID 494 + E + E RN + S+ K + +L + H DL P+N + Sbjct: 146 EFAPFEEIKKYESLIEEQIPYANYESVRNAVFSLEKRLADLGVDRKSCHIDLVPENFIES 205 Query: 495 SKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLS 554 + +L D++ S DP + DL L L + S E+ S+ E Q Sbjct: 206 PQGRLYLIDWEYSS--MNDP------MWDLAALFL---ESEFTSQEEETFLSHYESDQTP 254 Query: 555 PDEETKDLIHRLFH 568 E K I+++ Sbjct: 255 VSHE-KIAIYKILQ 267 >1VRD-A nrPDB Length = 494 Score = 30.4 bits (67), Expect = 3.2, Method: Composition-based stats. Identities = 19/116 (16%), Positives = 40/116 (34%), Gaps = 26/116 (22%) Query: 41 VQQLLEGGANVNFQEEEGGWTPLHNAVQMS--REDIVELLLRHGADPVLRKKNGATPFIL 98 ++ ++ + N +E G + AV S + VE L++ G D ++ Sbjct: 206 IKDIMSVIEHPNAARDEKGRLLVGAAVGTSPETMERVEKLVKAGVDVIVID--------- 256 Query: 99 AAIAGS----VKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGAN 150 G ++ L++ + D+ T + + L K GA+ Sbjct: 257 -TAHGHSRRVIETLEMIKADYPDLPVVAGNVATP----------EGTEALIKAGAD 301 >6FDN-A nrPDB Length = 320 Score = 30.1 bits (66), Expect = 3.6, Method: Composition-based stats. Identities = 32/186 (17%), Positives = 63/186 (33%), Gaps = 33/186 (17%) Query: 383 FYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLE 442 Y + A+K F +R+ + N H V + L Sbjct: 151 LYLSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAV--------------VMELINGYPL 196 Query: 443 ACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLA 502 +H ED + DE + I K G H D N+++D + Sbjct: 197 C--QIHHVEDPASVYDEA----MELIVKLANH-----GLIHGDFNEFNLILDESDHITMI 245 Query: 503 DFDKSIKWAGDPQ---EVKRDLEDLGRLVL--YVVKKGSIS-FEDLKAQSNEEVVQLSPD 556 DF + + + P RD++ + + + + F+D++ + + V++S Sbjct: 246 DFPQMVSTS-HPNAEWYFDRDVKCIKDFFMKRFSYESELFPTFKDIRREDTLD-VEVSAS 303 Query: 557 EETKDL 562 TK++ Sbjct: 304 GYTKEM 309 >3ATG-A nrPDB Length = 256 Score = 30.1 bits (66), Expect = 4.0, Method: Composition-based stats. Identities = 17/57 (29%), Positives = 26/57 (45%), Gaps = 1/57 (1%) Query: 327 EDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFID-EKYKIADTSEGGIYLG 382 + FH A DWKP W + HR+ R +G + D + I + + GG + G Sbjct: 162 DTFHTFAVDWKPGEITWFVDGQQFHRVTRASVGANAWVFDQPFFLILNVAVGGQWPG 218 >3OET-A nrPDB Length = 381 Score = 29.7 bits (65), Expect = 5.5, Method: Composition-based stats. Identities = 13/49 (26%), Positives = 23/49 (46%), Gaps = 1/49 (2%) Query: 475 LHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKW-AGDPQEVKRDLE 522 LHL+ + L+P ILI++ + + + + AG P V D+ Sbjct: 189 LHLADETLIRRLKPGAILINACRGPVVDNAALLARLNAGQPLSVVLDVW 237 >2W1Z-A nrPDB Length = 368 Score = 29.3 bits (64), Expect = 6.5, Method: Composition-based stats. Identities = 10/26 (38%), Positives = 14/26 (53%) Query: 480 GYTHQDLQPQNILIDSKKAAHLADFD 505 G H D Q +NIL+D + L F+ Sbjct: 211 GLVHADFQVRNILLDQRGGVFLTGFE 236 >6C2H-A nrPDB Length = 375 Score = 29.3 bits (64), Expect = 6.7, Method: Composition-based stats. Identities = 16/54 (29%), Positives = 22/54 (40%) Query: 305 VMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMI 358 ++T + V VL + GA+ P A W SH G A K I +I Sbjct: 123 IITLPEKMSNEKVSVLKALGAEIIRTPTAAAWDSPESHIGVAKKLEKEIPGAVI 176 >1F8S-A nrPDB Length = 498 Score = 29.3 bits (64), Expect = 7.2, Method: Composition-based stats. Identities = 26/161 (16%), Positives = 54/161 (33%), Gaps = 24/161 (14%) Query: 446 DVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFD 505 + ++E++ A + +I K V E+ G ++P Sbjct: 104 KFDLRLNEFSQENDNAWYFIKNIRKKVGEVKKDPGLLKYPVKPSE--------------- 148 Query: 506 KSIKWAGDPQEVKRDLEDLGRLV--LYVVKKGSISFEDLKAQSNEEVV-QLSPDEETKDL 562 + K AG E E LG++V L I + + E ++ + D+ Sbjct: 149 -AGKSAGQLYE-----ESLGKVVEELKRTNCSYILNKYDTYSTKEYLIKEGDLSPGAVDM 202 Query: 563 IHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNES 603 I L + + L H + +E R+ + + ++ Sbjct: 203 IGDLLNEDSGYYVSFIESLKHDDIFAYEKRFDEIVDGMDKL 243 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.132 0.346 Lambda K H 0.267 0.0402 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 27,275,675 Number of Sequences: 36641 Number of extensions: 1077965 Number of successful extensions: 7595 Number of sequences better than 10.0: 567 Number of HSP's better than 10.0 without gapping: 626 Number of HSP's successfully gapped in prelim test: 214 Number of HSP's that attempted gapping in prelim test: 3482 Number of HSP's gapped (non-prelim): 1522 length of query: 741 length of database: 10,336,785 effective HSP length: 104 effective length of query: 637 effective length of database: 6,526,121 effective search space: 4157139077 effective search space used: 4157139077 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 63 (28.9 bits)