BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q04491 (297 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3JRO-A nrPDB 618 e-177 3JRP-A nrPDB 609 e-175 4BZK-B nrPDB 605 e-174 4L9O-A nrPDB 436 e-123 4YCZ-A nrPDB 343 5e-95 3BG0-A nrPDB 293 8e-80 5A9Q-7 nrPDB 136 1e-32 3F3P-A nrPDB 99 2e-21 3FM0-A nrPDB 87 7e-18 1VYH-C nrPDB 71 7e-13 6QX9-5O nrPDB 67 7e-12 2HES-X nrPDB 58 4e-09 5MZH-A nrPDB 55 3e-08 5NNZ-B nrPDB 55 4e-08 5WJC-A nrPDB 54 1e-07 5OQL-J nrPDB 54 1e-07 2H9P-A nrPDB 52 3e-07 5M25-A nrPDB 52 3e-07 6EMK-B nrPDB 52 3e-07 5GAN-H nrPDB 50 1e-06 5L9T-R nrPDB 50 1e-06 6QDV-o nrPDB 50 2e-06 5YZG-W nrPDB 49 2e-06 3C9C-A nrPDB 49 2e-06 3CFV-B nrPDB 48 4e-06 5Y1U-A nrPDB 48 5e-06 6EOJ-D nrPDB 47 1e-05 6GMH-W nrPDB 46 1e-05 5FVM-C nrPDB 46 2e-05 5A9Q-2 nrPDB 45 3e-05 5FL8-q nrPDB 45 3e-05 6G51-g nrPDB 44 6e-05 4V6W-Ag nrPDB 44 8e-05 6F3T-A nrPDB 44 9e-05 4XYI-A nrPDB 44 9e-05 6HQA-B nrPDB 44 1e-04 5Y88-O nrPDB 43 1e-04 6MZM-G nrPDB 43 2e-04 6QX9-4B nrPDB 43 2e-04 3DM0-A nrPDB 43 2e-04 5WYJ-BC nrPDB 42 3e-04 4XFV-A nrPDB 42 3e-04 3JB9-g nrPDB 42 3e-04 6N9G-C nrPDB 42 4e-04 2AQ5-A nrPDB 41 5e-04 3DWL-C nrPDB 41 6e-04 5K1B-B nrPDB 41 7e-04 5FA5-B nrPDB 41 7e-04 2P9P-C nrPDB 40 0.001 5WLC-LO nrPDB 40 0.001 5I2T-A nrPDB 40 0.002 5NZU-C nrPDB 40 0.002 4BTS-AR nrPDB 39 0.002 3JAP-g nrPDB 39 0.003 3ODT-A nrPDB 38 0.005 1NR0-A nrPDB 38 0.006 4GGA-A nrPDB 37 0.007 5G04-R nrPDB 37 0.008 5LCW-Q nrPDB 37 0.008 4V8M-A7 nrPDB 37 0.010 4AEZ-A nrPDB 37 0.010 6CHG-A nrPDB 37 0.011 4N14-A nrPDB 37 0.012 4A11-B nrPDB 35 0.029 6BX3-A nrPDB 35 0.036 6F1U-h nrPDB 35 0.042 5Z56-q nrPDB 35 0.048 5UZ7-B nrPDB 35 0.048 5K19-A nrPDB 35 0.054 1PI6-A nrPDB 35 0.054 4V7E-Bg nrPDB 34 0.059 5XYI-g nrPDB 34 0.073 5OPT-p nrPDB 34 0.084 4LG8-A nrPDB 34 0.084 3MKQ-A nrPDB 34 0.092 5OQL-d nrPDB 33 0.10 6ID0-T nrPDB 33 0.11 2PM9-A nrPDB 33 0.12 2YNP-A nrPDB 33 0.12 3JB9-L nrPDB 33 0.17 3W15-A nrPDB 33 0.18 6HHQ-h nrPDB 33 0.21 4U1E-I nrPDB 32 0.30 6J6H-n nrPDB 32 0.32 5TF2-A nrPDB 32 0.41 5WBU-D nrPDB 32 0.48 4PSX-B nrPDB 32 0.48 4G56-B nrPDB 32 0.48 5OQL-L nrPDB 31 0.63 6Q8F-A nrPDB 31 0.65 5OQL-X nrPDB 30 1.1 5K0Y-T nrPDB 30 1.2 5CXC-A nrPDB 30 1.2 5BJS-A nrPDB 30 1.5 4J0X-A nrPDB 29 2.1 4KIC-A nrPDB 29 2.3 5WLC-SG nrPDB 29 2.6 5WYK-BB nrPDB 29 2.7 4OWR-A nrPDB 29 2.9 4NOX-A nrPDB 29 3.0 5MOG-A nrPDB 28 4.1 4RUH-A nrPDB 28 4.2 6C0F-s nrPDB 28 4.5 5WLC-LU nrPDB 28 4.6 6CB1-s nrPDB 28 4.7 6EM1-m nrPDB 28 4.8 2AS0-A nrPDB 28 6.6 2ZYL-A nrPDB 27 8.0 2GBG-A nrPDB 27 9.6 >3JRO-A nrPDB Length = 753 Score = 618 bits (1593), Expect = e-177, Method: Compositional matrix adjust. Identities = 297/297 (100%), Positives = 297/297 (100%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD Sbjct: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS Sbjct: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN Sbjct: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 Query: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ Sbjct: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 Query: 241 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ Sbjct: 241 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 >3JRP-A nrPDB Length = 379 Score = 609 bits (1570), Expect = e-175, Method: Compositional matrix adjust. Identities = 297/297 (100%), Positives = 297/297 (100%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD Sbjct: 3 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 62 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS Sbjct: 63 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 122 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN Sbjct: 123 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 182 Query: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ Sbjct: 183 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 242 Query: 241 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ Sbjct: 243 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 299 >4BZK-B nrPDB Length = 297 Score = 605 bits (1559), Expect = e-174, Method: Compositional matrix adjust. Identities = 297/297 (100%), Positives = 297/297 (100%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD Sbjct: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS Sbjct: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN Sbjct: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 Query: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ Sbjct: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 Query: 241 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ Sbjct: 241 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 >4L9O-A nrPDB Length = 349 Score = 436 bits (1122), Expect = e-123, Method: Compositional matrix adjust. Identities = 202/296 (68%), Positives = 247/296 (83%), Gaps = 8/296 (2%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 V I NAH++LIHDAVLDYYG+RLATCSSDKTIKIFE++GE +L++TL GHEGPVW+V W Sbjct: 62 VTIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAW 121 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 AHPKFG ILASCSYDGKVLIWKE+NG W+++A H+VH ASVNSV WAPHEYGP+LL ASS Sbjct: 122 AHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASS 181 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 DGK+S+VEFK+ G PI+I HAIGVN+ASWAP ++ ++ +R+FV+GG DNL Sbjct: 182 DGKISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDN--------TRRFVSGGCDNL 233 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQG 241 VKIW+Y+ A+T++ E +GHSDWVRDVAWSP+ L +SY+A+ SQDRT +IWT+D + Sbjct: 234 VKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSN 293 Query: 242 PWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 W+K L +EKFPDV WRASWSLSGNVLA+SGGDNKVTLWKEN++GKWE AGEV Q Sbjct: 294 KWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLWKENIQGKWESAGEVDQ 349 >4YCZ-A nrPDB Length = 876 Score = 343 bits (880), Expect = 5e-95, Method: Compositional matrix adjust. Identities = 180/295 (61%), Positives = 214/295 (72%), Gaps = 11/295 (3%) Query: 3 VIANA-HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 VIAN+ H+++IHDAVLDYYG+RLATCSSD+TIKIFE+EGET +L +TL GH+G VW V W Sbjct: 11 VIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSW 70 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 AHPK+G ILAS YDGKVLIW+E NG W +I A+H ASVN V W+PHE G LL ASS Sbjct: 71 AHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASS 130 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPAT----IEEDGEHNGTKESRKFVTGG 177 DG VSV+EF++N + I AH +GVNS SWAPAT I + +R+FVTGG Sbjct: 131 DGNVSVLEFRDN-SWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGG 189 Query: 178 ADNLVKIWKYNSDAQTYVLES-TLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ 236 +DN +KIW Y+ TY LE L GH+DWVRDVAWSPTVL +SY+AS S+DRT IWT Sbjct: 190 SDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTS 249 Query: 237 DNEQG-PWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWE 290 D W +L F +WR SWSLSGNVLA SGGDNKVTLWKENL+G+WE Sbjct: 250 DPANPLQWNCKVL---NFDAAVWRVSWSLSGNVLAASGGDNKVTLWKENLKGEWE 301 >3BG0-A nrPDB Length = 316 Score = 293 bits (749), Expect = 8e-80, Method: Compositional matrix adjust. Identities = 156/308 (50%), Positives = 205/308 (66%), Gaps = 14/308 (4%) Query: 1 MVVIAN----AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPV 56 MV + N +H ++IHDA +DYYG RLATCSSD+++KIF+V LI L GHEGPV Sbjct: 1 MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV 60 Query: 57 WRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLL 116 W+V WAHP +G ILASCSYD KV+IW+EENG W + HA H +SVNSV WAPH+YG +L Sbjct: 61 WQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLIL 120 Query: 117 LVASSDGKVSVVEFKENGT-TSPIIIDAHAIGVNSASWAPATIEED--GEHNGTKES--R 171 SSDG +S++ + G I +AH IG N+ SWAPA + +G K + + Sbjct: 121 ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIK 180 Query: 172 KFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV-LLRSYLASVSQDRT 230 +F +GG DNL+K+WK D Q + E LE HSDWVRDVAW+P++ L S +AS SQD Sbjct: 181 RFASGGCDNLIKLWKEEEDGQ-WKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239 Query: 231 CIIWTQDN-EQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKW 289 IWT D+ W LL KF DV+W SWS++ N+LA+SGGDNKVTLWKE+++G+W Sbjct: 240 VFIWTCDDASSNTWSPKLL--HKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQW 297 Query: 290 EPAGEVHQ 297 +V++ Sbjct: 298 VCISDVNK 305 >5A9Q-7 nrPDB Length = 360 Score = 136 bits (343), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 99/322 (30%), Positives = 157/322 (48%), Gaps = 43/322 (13%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE--GETHKLIDTLTGHEGPVWRVDW 61 IA H +LIHD D++G+R+ATCSSD+++K+++ G+ H + H G VWRV W Sbjct: 7 IAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWH-CTASWKTHSGSVWRVTW 65 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGR----------WSQIAVHAVHSASVNSVQWAPHE 111 AHP+FG +LASCS+D +W+E G W + SV V++AP Sbjct: 66 AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKH 125 Query: 112 YGPLLLVASSDGKVSVVEFKENGTTSPIIID---AHAIGVNSASWAPATIEEDGEHNGTK 168 G +L S+DG V + E + S + + + + SW P++ ++ Sbjct: 126 MGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSS---------SR 176 Query: 169 ESRKFVTGGADN-------LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSY 221 + G+D+ V+I++YN + + Y TL +D V D+A++P L RS+ Sbjct: 177 AHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPN-LGRSF 235 Query: 222 --LASVSQDRTCIIWTQDNEQ-----GPWKKTLLKEEKFPD---VLWRASWSLSGNVLAL 271 LA ++D ++ GP K + +F + +WR SW+++G VLA Sbjct: 236 HILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLAS 295 Query: 272 SGGDNKVTLWKENLEGKWEPAG 293 SG D V LWK N W+ G Sbjct: 296 SGDDGCVRLWKANYMDNWKCTG 317 >3F3P-A nrPDB Length = 351 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 64/236 (27%), Positives = 116/236 (49%), Gaps = 32/236 (13%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETH--KLIDTLTGHEGPVWR 58 M + H++L+HD V D+YG+ +ATCSSD+ IK+F+++ +T +L D+ H+ + Sbjct: 3 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 62 Query: 59 VDWAHPKFGTILASCSYDGKVLIWKEE-------NGRWSQIAVHAVHSASVNSVQWAPHE 111 +DWA P++G I+AS SYD V +W+E+ RW+++ S+ SV++AP Sbjct: 63 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 122 Query: 112 YGPLLLVASSDGKVSVVEFKENG------TTSPIIIDA-----HAIGVNSASWAPATIEE 160 G L +DG + + + E TS + + + H SW P+ Sbjct: 123 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 182 Query: 161 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV 216 + K + + I++ D + +V + L GH +R ++W+P++ Sbjct: 183 E----------KLAVSALEQAI-IYQRGKDGKLHV-AAKLPGHKSLIRSISWAPSI 226 Score = 32.3 bits (72), Expect = 0.28, Method: Compositional matrix adjust. Identities = 18/40 (45%), Positives = 22/40 (55%), Gaps = 2/40 (5%) Query: 44 KLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 +L+ H G VW V W GTIL+S DGKV +WK Sbjct: 297 ELLSEHDDHNGEVWSVSWNLT--GTILSSAGDDGKVRLWK 334 Score = 32.0 bits (71), Expect = 0.30, Method: Compositional matrix adjust. Identities = 18/70 (25%), Positives = 33/70 (47%), Gaps = 1/70 (1%) Query: 171 RKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT 230 R T +D +K++K + D + L + H + + W+ R +AS S D+T Sbjct: 24 RHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGR-IIASASYDKT 82 Query: 231 CIIWTQDNEQ 240 +W +D +Q Sbjct: 83 VKLWEEDPDQ 92 >3FM0-A nrPDB Length = 345 Score = 87.4 bits (215), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 79/277 (28%), Positives = 119/277 (42%), Gaps = 35/277 (12%) Query: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLT-GHEGPVWRVDWAHPKFGTILASCSYDGKV 79 G LA+C D+ I+I+ EG++ L+ GH+ V +V W+ G LAS S+D Sbjct: 28 GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWS--PCGNYLASASFDATT 85 Query: 80 LIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI 139 IWK+ + + H V SV WAP G LL S D V V E E + Sbjct: 86 CIWKKNQDDFECVTTLEGHENEVKSVAWAPS--GNLLATCSRDKSVWVWEVDEEDEYECV 143 Query: 140 -IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLES 198 ++++H V W P+ + D+ VK+++ D +V + Sbjct: 144 SVLNSHTQDVKHVVWHPS-------------QELLASASYDDTVKLYREEED--DWVCCA 188 Query: 199 TLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ---DNEQG--------PWKKTL 247 TLEGH V +A+ P+ LAS S DRT IW Q NEQG WK Sbjct: 189 TLEGHESTVWSLAFDPS---GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCIC 245 Query: 248 LKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 ++ +W LA + GD+ + +++E+ Sbjct: 246 TLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQED 282 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 73/298 (24%), Positives = 118/298 (39%), Gaps = 38/298 (12%) Query: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 V++ H + G LA+ S D T I++ + + + TL GHE V V WA Sbjct: 55 VLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWA 114 Query: 63 HPKFGTILASCSYDGKVLIWK-EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 G +LA+CS D V +W+ +E + ++V H+ V V W P + LL AS Sbjct: 115 --PSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQ--ELLASASY 170 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 D V + +E+ ++ H V S ++ P+ ++ + D Sbjct: 171 DDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPS-------------GQRLASCSDDRT 217 Query: 182 VKIWK-----------YNSDAQTYVLESTLEG-HSDWVRDVAWSPTVLLRSYLASVSQDR 229 V+IW+ + ++ TL G HS + D+AW L LA+ D Sbjct: 218 VRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAW---CQLTGALATACGDD 274 Query: 230 TCIIWTQDNEQGPWKKTL-----LKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 ++ +D P + T L + DV A +LA D +V WK Sbjct: 275 AIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWK 332 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/222 (26%), Positives = 93/222 (41%), Gaps = 23/222 (10%) Query: 67 GTILASCSYDGKVLIWKEENGRW-SQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 GT+LASC D ++ IW E W + + H +V V W+P G L AS D Sbjct: 28 GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSP--CGNYLASASFDATT 85 Query: 126 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 + + ++ ++ H V S +WAP+ T D V +W Sbjct: 86 CIWKKNQDDFECVTTLEGHENEVKSVAWAPS-------------GNLLATCSRDKSVWVW 132 Query: 186 KYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKK 245 + + + + Y S L H+ V+ V W P+ L LAS S D T ++ ++ + Sbjct: 133 EVDEEDE-YECVSVLNSHTQDVKHVVWHPSQEL---LASASYDDTVKLYREEEDDWVCCA 188 Query: 246 TLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEG 287 TL E +W ++ SG LA D V +W++ L G Sbjct: 189 TL---EGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPG 227 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 82/211 (38%), Gaps = 41/211 (19%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 V + N+H + + V + LA+ S D T+K++ E + TL GHE VW + Sbjct: 142 CVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSL- 200 Query: 61 WAHPKFGTILASCSYDGKVLIWKE-----ENG--------RWSQIA-VHAVHSASVNSVQ 106 A G LASCS D V IW++ E G W I + HS ++ + Sbjct: 201 -AFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIA 259 Query: 107 WAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI---------IIDAHAIGVNSASWAPAT 157 W + L A D + V F+E+ + P + AH+ VN +W P Sbjct: 260 WC--QLTGALATACGDDAIRV--FQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNP-- 313 Query: 158 IEEDGEHNGTKESRKFVTGGADNLVKIWKYN 188 KE + D V WKY Sbjct: 314 ----------KEPGLLASCSDDGEVAFWKYQ 334 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 40/119 (33%), Positives = 61/119 (51%), Gaps = 9/119 (7%) Query: 173 FVTGGADNLVKIWKYNSDAQTYVLESTL-EGHSDWVRDVAWSPTVLLRSYLASVSQDRTC 231 + G D ++IW D +++ +S L EGH VR VAWSP +YLAS S D T Sbjct: 31 LASCGGDRRIRIWGTEGD--SWICKSVLSEGHQRTVRKVAWSP---CGNYLASASFDATT 85 Query: 232 IIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWE 290 IW ++ + TL E + + +W+ SGN+LA D V +W+ + E ++E Sbjct: 86 CIWKKNQDDFECVTTL---EGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141 Score = 27.7 bits (60), Expect = 6.7, Method: Compositional matrix adjust. Identities = 9/25 (36%), Positives = 16/25 (64%) Query: 257 LWRASWSLSGNVLALSGGDNKVTLW 281 W +W+ +G +LA GGD ++ +W Sbjct: 19 CWFLAWNPAGTLLASCGGDRRIRIW 43 >1VYH-C nrPDB Length = 410 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 83/289 (28%), Positives = 130/289 (44%), Gaps = 39/289 (13%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 H + + D D+ GK LA+CS+D TIK+++ +G + I T+ GH+ V V P Sbjct: 147 KGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQG--FECIRTMHGHDHNVSSVS-IMPN 203 Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 G + S S D + +W+ + G + H V V+ P++ G L+ S+D V Sbjct: 204 -GDHIVSASRDKTIKMWEVQTGYC--VKTFTGHREWVRMVR--PNQDGTLIASCSNDQTV 258 Query: 126 S--VVEFKENGTTSPIIIDAHAIGVNSASWAP-ATIEEDGEHNG--TKESRK----FVTG 176 VV KE + H V SWAP ++ E G TK+S K ++G Sbjct: 259 RVWVVATKECKAE----LREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSG 314 Query: 177 GADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ 236 D +K+W D T + TL GH +WVR V + ++ S + D+T +W Sbjct: 315 SRDKTIKMW----DVSTGMCLMTLVGHDNWVRGVLFHSG---GKFILSCADDKTLRVWDY 367 Query: 237 DNEQGPWKKTLLKEEKFP---DVLWRASWSLSGNVLALSGGDNKVTLWK 282 N++ KTL E F D A + ++G+V D V +W+ Sbjct: 368 KNKR--CMKTLNAHEHFVTSLDFHKTAPYVVTGSV------DQTVKVWE 408 Score = 36.6 bits (83), Expect = 0.013, Method: Compositional matrix adjust. Identities = 22/62 (35%), Positives = 34/62 (54%), Gaps = 7/62 (11%) Query: 173 FVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 232 V+ D +K+W Y +T E TL+GH+D V+D+++ + L LAS S D T Sbjct: 123 MVSASEDATIKVWDY----ETGDFERTLKGHTDSVQDISFDHSGKL---LASCSADMTIK 175 Query: 233 IW 234 +W Sbjct: 176 LW 177 >6QX9-5O nrPDB Length = 357 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 74/286 (25%), Positives = 117/286 (40%), Gaps = 38/286 (13%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 +++ + H ++ G LA+ D+ I ++ V G+ TL GH G V + + Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYA-TLKGHSGAVMELHY 117 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGP-LLLVAS 120 G++L S S D V +W E G ++ H++ VNS P GP L+ S Sbjct: 118 NTD--GSMLFSASTDKTVAVWDSETGE--RVKRLKGHTSFVNSCY--PARRGPQLVCTGS 171 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 DG V + + ++ + V N T S + ++GG DN Sbjct: 172 DDGTVKLWDIRKKAAIQTFQNTYQVLAVT--------------FNDT--SDQIISGGIDN 215 Query: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 +K+W + TY T+ GH+D V ++ S SYL S + D T +W D Sbjct: 216 DIKVWDLRQNKLTY----TMRGHADSVTGLSLSSE---GSYLLSNAMDNTVRVW--DVRP 266 Query: 241 GPWKKTLLK-----EEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 K+ +K F L R SWS G+ +A D V +W Sbjct: 267 FAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312 >2HES-X nrPDB Length = 330 Score = 58.2 bits (139), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 76/288 (26%), Positives = 125/288 (43%), Gaps = 37/288 (12%) Query: 17 LDYYGKRLATCSSDKTIKIFEVEGETHKLIDTL--TGHEGPVWRVDWAHPKFGTILASCS 74 D+ LAT S+D+ IK+ V+ + LID L T H+ + V W P ++LA+ S Sbjct: 20 FDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAW-RPH-TSLLAAGS 77 Query: 75 YDGKVLIW-KEENG----RWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVE 129 +D V IW KEE+ +A+ H V V W+ G L S D V + E Sbjct: 78 FDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSND--GYYLATCSRDKSVWIWE 135 Query: 130 FKENGTTSPII--IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK- 186 E+G I + H+ V W P+ + D+ V+IWK Sbjct: 136 TDESGEEYECISVLQEHSQDVKHVIWHPS-------------EALLASSSYDDTVRIWKD 182 Query: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT 246 Y+ D + + + EG + W D + V L S S D T +W + ++ Sbjct: 183 YDDDWECVAVLNGHEG-TVWSSDFDKTEGVF---RLCSGSDDSTVRVWKYMGDDEDDQQE 238 Query: 247 LLKEEKFPDV----LWRASWSLSGNVLALSGGDNKVTLWKENLEGKWE 290 + E PDV ++ +W +G ++A G D + +++E ++G+W+ Sbjct: 239 WVCEAILPDVHKRQVYNVAWGFNG-LIASVGADGVLAVYEE-VDGEWK 284 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 49/163 (30%), Positives = 71/163 (43%), Gaps = 11/163 (6%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE--GETHKLIDTLTGHEGPVWR 58 ++ I H + G LATCS DK++ I+E + GE ++ I L H V Sbjct: 99 LLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKH 158 Query: 59 VDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 118 V W HP +LAS SYD V IWK+ + W +AV H +V S + E L Sbjct: 159 VIW-HPS-EALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCS 216 Query: 119 ASSDGKVSVVEF-------KENGTTSPIIIDAHAIGVNSASWA 154 S D V V ++ ++ I+ D H V + +W Sbjct: 217 GSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWG 259 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 66/247 (26%), Positives = 102/247 (41%), Gaps = 34/247 (13%) Query: 45 LIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAV--HAVHSASV 102 LI +L ++ +W D++ ILA+ S D K+ + + ++ I V H ++ Sbjct: 6 LIKSLKLYKEKIWSFDFSQG----ILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAI 61 Query: 103 NSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTS-----PIIIDAHAIGVNSASWAPAT 157 SV W PH LL S D VS+ +E+ + II+ H V +W+ Sbjct: 62 RSVAWRPHT--SLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWS--- 116 Query: 158 IEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVL 217 DG + T D V IW+ + + Y S L+ HS V+ V W P+ Sbjct: 117 --NDGYY--------LATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEA 166 Query: 218 LRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGG--D 275 L LAS S D T IW ++ L E +W + + + V L G D Sbjct: 167 L---LASSSYDDTVRIWKDYDDDWECVAVLNGHEG---TVWSSDFDKTEGVFRLCSGSDD 220 Query: 276 NKVTLWK 282 + V +WK Sbjct: 221 STVRVWK 227 >5MZH-A nrPDB Length = 452 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 71/294 (24%), Positives = 124/294 (42%), Gaps = 55/294 (18%) Query: 20 YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKV 79 YG ++ T S DKT K++ + T +L TL GH+ + + + +P+ TI+A+ S D Sbjct: 148 YGDKIVTGSFDKTCKLW--DAYTGQLYYTLKGHQTEIVCLSF-NPQ-STIIATGSMDNTA 203 Query: 80 LIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD----------------- 122 +W E G+ + A A H A + S+ + + G L++ S D Sbjct: 204 KLWDVETGQ--ERATLAGHRAEIVSLGF--NTGGDLIVTGSFDHDSRLWDVRTGQCVHVL 259 Query: 123 ----GKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKE--------- 169 G+VS +F GT ++ + +I S W + G + Sbjct: 260 SGHRGEVSSTQFNYAGT----LVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDA 315 Query: 170 -SRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQD 228 K V+ AD +++ T V + TL GH + VA++P + L + S D Sbjct: 316 AGTKMVSASADGSARLYH----TLTGVCQHTLVGHEGEISKVAFNPQ---GTRLITASSD 368 Query: 229 RTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 +TC +W D + G + L E D ++ +++ G+ + DN +WK Sbjct: 369 KTCRLW--DCDTGECLQVL---EGHTDEIFSCAFNYEGDFIITGSKDNTCRIWK 417 Score = 35.4 bits (80), Expect = 0.033, Method: Compositional matrix adjust. Identities = 30/114 (26%), Positives = 49/114 (42%), Gaps = 11/114 (9%) Query: 168 KESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQ 227 K +F+TG D K+W + + + TLEGH + V +A++ + + S Sbjct: 104 KSGDRFITGSYDRTCKVWNTFTGEEVF----TLEGHKNVVYAIAFNNP--YGDKIVTGSF 157 Query: 228 DRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 D+TC +W D G TL + L S++ ++A DN LW Sbjct: 158 DKTCKLW--DAYTGQLYYTLKGHQTEIVCL---SFNPQSTIIATGSMDNTAKLW 206 >5NNZ-B nrPDB Length = 415 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 72/264 (27%), Positives = 115/264 (43%), Gaps = 39/264 (14%) Query: 20 YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKV 79 YG ++AT S DKT K++ V ET K T GH + + + +P+ T++A+ S D Sbjct: 146 YGDKIATGSFDKTCKLWSV--ETGKCYHTFRGHTAEIVCLSF-NPQ-STLVATGSMDTTA 201 Query: 80 LIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI 139 +W +NG ++ HSA + S+ + + G ++ S D V VV + G I Sbjct: 202 KLWDIQNGE--EVYTLRGHSAEIISLSF--NTSGDRIITGSFDHTV-VVWDADTGRKVNI 256 Query: 140 IIDAHAIGVNSAS--WAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLE 197 +I H ++SAS W + I +TG D K+W DA Sbjct: 257 LI-GHCAEISSASFNWDCSLI---------------LTGSMDKTCKLW----DATNGKCV 296 Query: 198 STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVL 257 +TL GH D + D + T L +A+ S D T I++ +K + K E + Sbjct: 297 ATLTGHDDEILDSCFDYTGKL---IATASADGTARIFS-----AATRKCIAKLEGHEGEI 348 Query: 258 WRASWSLSGNVLALSGGDNKVTLW 281 + S++ GN L D +W Sbjct: 349 SKISFNPQGNHLLTGSSDKTARIW 372 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 32/91 (35%), Positives = 48/91 (52%), Gaps = 4/91 (4%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 V H++ I D+ DY GK +AT S+D T +IF T K I L GHEG + ++ + Sbjct: 296 VATLTGHDDEILDSCFDYTGKLIATASADGTARIF--SAATRKCIAKLEGHEGEISKISF 353 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQI 92 +P+ G L + S D IW + G+ Q+ Sbjct: 354 -NPQ-GNHLLTGSSDKTARIWDAQTGQCLQV 382 Score = 35.8 bits (81), Expect = 0.024, Method: Compositional matrix adjust. Identities = 42/185 (22%), Positives = 74/185 (40%), Gaps = 23/185 (12%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 V I H I A ++ + T S DKT K+++ K + TLTGH+ + +D Sbjct: 254 VNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWD--ATNGKCVATLTGHDDEI--LDS 309 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 G ++A+ S DG I+ + IA H ++ + + P G LL SS Sbjct: 310 CFDYTGKLIATASADGTARIFSAATRKC--IAKLEGHEGEISKISFNPQ--GNHLLTGSS 365 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 D + + + +++ H + S ++ + +TG DN Sbjct: 366 DKTARIWDAQTGQCLQ--VLEGHTDEIFSCAF-------------NYKGNIVITGSKDNT 410 Query: 182 VKIWK 186 +IW+ Sbjct: 411 CRIWR 415 Score = 32.3 bits (72), Expect = 0.24, Method: Compositional matrix adjust. Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 6/68 (8%) Query: 168 KESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQ 227 K F+TG D K+W S + +TLEGH + V +A++ +A+ S Sbjct: 102 KSGSCFITGSYDRTCKLWDTASGEEL----NTLEGHRNVVYAIAFNNPY--GDKIATGSF 155 Query: 228 DRTCIIWT 235 D+TC +W+ Sbjct: 156 DKTCKLWS 163 >5WJC-A nrPDB Length = 430 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 53/195 (27%), Positives = 80/195 (41%), Gaps = 28/195 (14%) Query: 49 LTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRW--------SQIAVHAVHSA 100 L GH + + W +P LA+ + D + +W + + S IA + H+ Sbjct: 178 LKGHTAEGFGLCW-NPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTD 236 Query: 101 SVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTT-SPIIIDAHAIGVNSASWAPATIE 159 VN VQ+ P ++ LL S D + + + + N +P +I AH+ +N+ + P Sbjct: 237 IVNDVQFHP-QHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFN-- 293 Query: 160 EDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLR 219 T AD V +W + Q TLEGH D V + WSP Sbjct: 294 ----------DYLLATASADKTVALWDLRNPYQRL---HTLEGHEDEVYGLEWSPHD--E 338 Query: 220 SYLASVSQDRTCIIW 234 LAS S DR IW Sbjct: 339 PILASSSTDRRVCIW 353 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 35/121 (28%), Positives = 61/121 (50%), Gaps = 15/121 (12%) Query: 4 IANAHNELIHDAVLDYYGKRL-ATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 + AH++ I+ ++ + L AT S+DKT+ ++++ +L TL GHE V+ ++W+ Sbjct: 276 VIQAHSKAINAVAINPFNDYLLATASADKTVALWDLRNPYQRL-HTLEGHEDEVYGLEWS 334 Query: 63 HPKFGTILASCSYDGKVLIW------------KEENGRWSQIAVHAVHSASVNSVQWAPH 110 P ILAS S D +V IW E+G + +H H+ ++ W P+ Sbjct: 335 -PHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPN 393 Query: 111 E 111 E Sbjct: 394 E 394 >5OQL-J nrPDB Length = 912 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 76/312 (24%), Positives = 119/312 (38%), Gaps = 45/312 (14%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE--GETHKLIDTLTGHEGPVWRV 59 V + H +++ +D+ G +A+ S D T +++ V+ ++ TGH V V Sbjct: 426 VALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAV 485 Query: 60 DWAHPKF----------------GTILASCSYDGKVLIWK-----EENGRWSQIAVHAVH 98 A PK L S S D V ++ G+ + H Sbjct: 486 --ALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAH 543 Query: 99 SASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATI 158 +N++ +P+ G L AS D V + + ++ I+ H GV + +AP Sbjct: 544 DKDINALDISPN--GKLFASASQDKTVKIWDVEKLEVQG--ILRGHKRGVWTVRFAPLNT 599 Query: 159 EEDGEHNGTKESRKFV-TGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAW----- 212 G+ R V TG D +K+W + Y T EGHS V V W Sbjct: 600 PVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSD----YTCIRTFEGHSHNVLKVVWLHISR 655 Query: 213 -SPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLAL 271 + AS D +W D G + TL E D LW + N+LA Sbjct: 656 DDSITKTKVQFASAGADTLVKVW--DANTGETECTLDNHE---DRLWTLAVHSKTNILAS 710 Query: 272 SGGDNKVTLWKE 283 +G D+KVT W++ Sbjct: 711 AGSDSKVTFWRD 722 >2H9P-A nrPDB Length = 329 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 55/231 (23%), Positives = 103/231 (44%), Gaps = 24/231 (10%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H+ + + + + S D++++I++V+ T K + TL H PV V + Sbjct: 122 GHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK--TGKCLKTLPAHSDPVSAVHFNRD-- 177 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 G+++ S SYDG IW +G+ + + + V+ V+++P+ G +L A+ D + Sbjct: 178 GSLIVSSSYDGLCRIWDTASGQCLKTLIDD-DNPPVSFVKFSPN--GKYILAATLDNTLK 234 Query: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 + ++ + + + N A G + V+G DNLV IW Sbjct: 235 LWDYSKGK-----CLKTYTGHKNEKYCIFANFSVTG-------GKWIVSGSEDNLVYIW- 281 Query: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQD 237 + QT + L+GH+D V A PT + + A++ D+T +W D Sbjct: 282 ---NLQTKEIVQKLQGHTDVVISTACHPTENIIAS-AALENDKTIKLWKSD 328 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 70/286 (24%), Positives = 121/286 (42%), Gaps = 41/286 (14%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIF-EVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 H + + G+ LA+ S+DK IKI+ +G+ K T++GH+ + V W+ Sbjct: 38 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK---TISGHKLGISDVAWSSD- 93 Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 +L S S D + IW +G+ + HS V + P L++ S D V Sbjct: 94 -SNLLVSASDDKTLKIWDVSSGKC--LKTLKGHSNYVFCCNFNPQS--NLIVSGSFDESV 148 Query: 126 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 + + K + AH+ V++ + ++ V+ D L +IW Sbjct: 149 RIWDVKTGKCLK--TLPAHSDPVSAVHF-------------NRDGSLIVSSSYDGLCRIW 193 Query: 186 KYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKK 245 A L++ ++ + V V +SP Y+ + + D T +W D +G K Sbjct: 194 ---DTASGQCLKTLIDDDNPPVSFVKFSPN---GKYILAATLDNTLKLW--DYSKGKCLK 245 Query: 246 TLL--KEEKFPDVLWRASWSLSGNVLALSGG-DNKVTLWKENLEGK 288 T K EK+ A++S++G +SG DN V +W NL+ K Sbjct: 246 TYTGHKNEKY---CIFANFSVTGGKWIVSGSEDNLVYIW--NLQTK 286 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 37/131 (28%), Positives = 53/131 (40%), Gaps = 19/131 (14%) Query: 173 FVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 232 + AD L+KIW A E T+ GH + DVAWS L L S S D+T Sbjct: 55 LASSSADKLIKIW----GAYDGKFEKTISGHKLGISDVAWSSDSNL---LVSASDDKTLK 107 Query: 233 IWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK-------ENL 285 IW D G KTL + ++ +++ N++ D V +W + L Sbjct: 108 IW--DVSSGKCLKTLKGHSNY---VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 162 Query: 286 EGKWEPAGEVH 296 +P VH Sbjct: 163 PAHSDPVSAVH 173 Score = 32.0 bits (71), Expect = 0.37, Method: Compositional matrix adjust. Identities = 28/89 (31%), Positives = 42/89 (47%), Gaps = 10/89 (11%) Query: 194 YVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEE-K 252 Y L+ TL GH+ V V +SP +LAS S D+ IW G ++KT+ + Sbjct: 30 YALKFTLAGHTKAVSSVKFSPN---GEWLASSSADKLIKIWGA--YDGKFEKTISGHKLG 84 Query: 253 FPDVLWRASWSLSGNVLALSGGDNKVTLW 281 DV +WS N+L + D + +W Sbjct: 85 ISDV----AWSSDSNLLVSASDDKTLKIW 109 >5M25-A nrPDB Length = 434 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 55/231 (23%), Positives = 104/231 (45%), Gaps = 24/231 (10%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H+ + + + + S D++++I++V+ T K + TL H PV V + + Sbjct: 227 GHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK--TGKCLKTLPAHSDPVSAVHFN--RD 282 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 G+++ S SYDG IW +G+ + + + V+ V+++P+ G +L A+ D + Sbjct: 283 GSLIVSSSYDGLCRIWDTASGQCLKTLIDD-DNPPVSFVKFSPN--GKYILAATLDNTLK 339 Query: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 + ++ + + + N A G + V+G DNLV IW Sbjct: 340 LWDYSKGK-----CLKTYTGHKNEKYCIFANFSVTG-------GKWIVSGSEDNLVYIW- 386 Query: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQD 237 + QT + L+GH+D V A PT + + A++ D+T +W D Sbjct: 387 ---NLQTKEIVQKLQGHTDVVISTACHPTENIIAS-AALENDKTIKLWKSD 433 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 49/180 (27%), Positives = 70/180 (38%), Gaps = 35/180 (19%) Query: 140 IIDAH--AIGVNSASWAPATIEED-------GEHNGTKESRKFVTGG-------ADNLVK 183 II+AH IG ++ P ++ + H S KF G AD L+K Sbjct: 111 IIEAHREQIGGSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIK 170 Query: 184 IWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPW 243 IW A E T+ GH + DVAWS L L S S D+T IW D G Sbjct: 171 IW----GAYDGKFEKTISGHKLGISDVAWSSDSNL---LVSASDDKTLKIW--DVSSGKC 221 Query: 244 KKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK-------ENLEGKWEPAGEVH 296 KTL + ++ +++ N++ D V +W + L +P VH Sbjct: 222 LKTLKGHSNY---VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH 278 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 70/286 (24%), Positives = 121/286 (42%), Gaps = 41/286 (14%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIF-EVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 H + + G+ LA+ S+DK IKI+ +G+ K T++GH+ + V W+ Sbjct: 143 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK---TISGHKLGISDVAWSSD- 198 Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 +L S S D + IW +G+ + HS V + P L++ S D V Sbjct: 199 -SNLLVSASDDKTLKIWDVSSGKC--LKTLKGHSNYVFCCNFNPQSN--LIVSGSFDESV 253 Query: 126 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 + + K + AH+ V++ + ++ V+ D L +IW Sbjct: 254 RIWDVKTGKCLK--TLPAHSDPVSAVHF-------------NRDGSLIVSSSYDGLCRIW 298 Query: 186 KYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKK 245 A L++ ++ + V V +SP Y+ + + D T +W D +G K Sbjct: 299 ---DTASGQCLKTLIDDDNPPVSFVKFSPN---GKYILAATLDNTLKLW--DYSKGKCLK 350 Query: 246 TLL--KEEKFPDVLWRASWSLSGNVLALSGG-DNKVTLWKENLEGK 288 T K EK+ A++S++G +SG DN V +W NL+ K Sbjct: 351 TYTGHKNEKY---CIFANFSVTGGKWIVSGSEDNLVYIW--NLQTK 391 >6EMK-B nrPDB Length = 303 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 89/212 (41%), Gaps = 25/212 (11%) Query: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 + T S D TIK+++V + I H PV V HP G ++ SC DG + IW Sbjct: 90 MVTSSEDGTIKVWDVRSPS---IPRNYKHNAPVNEV-VIHPNQGELI-SCDRDGNIRIWD 144 Query: 84 -EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIID 142 EN Q+ S+ S+ A G +L A++ G V E N T + + Sbjct: 145 LGENQCTHQLTPED--DTSLQSLSMASD--GSMLAAANTKGNCYVWEMP-NHTDASHLKP 199 Query: 143 AHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEG 202 +S + D +H T AD+ ++W + D + LE+TL+G Sbjct: 200 VTKFRAHSTYITRILLSSDVKH--------LATCSADHTARVWSIDDD---FKLETTLDG 248 Query: 203 HSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 H WV D A+S +YL + S D +W Sbjct: 249 HQRWVWDCAFSAD---SAYLVTASSDHYVRLW 277 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 27/76 (35%), Positives = 39/76 (51%), Gaps = 3/76 (3%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 AH+ I +L K LATCS+D T +++ ++ + KL TL GH+ VW D A Sbjct: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDD-FKLETTLDGHQRWVW--DCAFSAD 261 Query: 67 GTILASCSYDGKVLIW 82 L + S D V +W Sbjct: 262 SAYLVTASSDHYVRLW 277 >5GAN-H nrPDB Length = 465 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 57/230 (24%), Positives = 106/230 (46%), Gaps = 30/230 (13%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H I D GK + + S D T ++++ TH+ + GH+ V+ + + Sbjct: 263 GHERRISDVKYHPSGKFIGSASHDMTWRLWD--ASTHQELLLQEGHDKGVFSLSFQCD-- 318 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 G+++ S D ++W +G S++ A HS + +V W+P+ Y + DG ++ Sbjct: 319 GSLVCSGGMDSLSMLWDIRSG--SKVMTLAGHSKPIYTVAWSPNGYQ--VATGGGDGIIN 374 Query: 127 V--VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 V + ++ G + I+ AH V ++ +EDG +K V+ G DNL+ + Sbjct: 375 VWDIRKRDEGQLNQIL--AHRNIVTQVRFS----KEDG-------GKKLVSCGYDNLINV 421 Query: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 Y+SD T++ +L GH+D + + S +L S DR+ +W Sbjct: 422 --YSSD--TWLKMGSLAGHTDKIISLDISNN---SHFLVSGGWDRSIKLW 464 Score = 32.3 bits (72), Expect = 0.25, Method: Compositional matrix adjust. Identities = 21/104 (20%), Positives = 46/104 (44%), Gaps = 2/104 (1%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 V+ H++ I+ G ++AT D I ++++ ++ + H V +V + Sbjct: 342 VMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRF 401 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSV 105 + G L SC YD + ++ + W ++ A H+ + S+ Sbjct: 402 SKEDGGKKLVSCGYDNLINVYSSDT--WLKMGSLAGHTDKIISL 443 >5L9T-R nrPDB Length = 493 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 51/201 (25%), Positives = 85/201 (42%), Gaps = 23/201 (11%) Query: 15 AVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCS 74 L + ++L++ S D+ I ++ + L GH V + W+ +LAS Sbjct: 275 GALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDH--QLLASGG 332 Query: 75 YDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV-SVVEFKEN 133 D K+L+W + S + + H A+V ++ W+PH++G L+AS G + F Sbjct: 333 NDNKLLVWNHSS--LSPVQQYTEHLAAVKAIAWSPHQHG---LLASGGGTADRCIRFWNT 387 Query: 134 GTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQT 193 T P+ V + +W+ E H G + N + +WKY S Q Sbjct: 388 LTGQPLQCIDTGSQVCNLAWSKHANELVSTH-----------GYSQNQILVWKYPSLTQV 436 Query: 194 YVLESTLEGHSDWVRDVAWSP 214 + L GHS V +A SP Sbjct: 437 ----AKLTGHSYRVLYLAMSP 453 Score = 31.2 bits (69), Expect = 0.58, Method: Compositional matrix adjust. Identities = 32/106 (30%), Positives = 46/106 (43%), Gaps = 12/106 (11%) Query: 176 GGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 G V+IW DA S LEGH+ V +AW+ L+S S+DR +I Sbjct: 247 GTHKGFVQIW----DAAAGKKLSMLEGHTARVGALAWNA-----EQLSSGSRDR--MILQ 295 Query: 236 QDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 +D P + + +V WS +LA G DNK+ +W Sbjct: 296 RDIRTPPLQSERRLQGHRQEVCG-LKWSTDHQLLASGGNDNKLLVW 340 >6QDV-o nrPDB Length = 513 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 64/263 (24%), Positives = 104/263 (39%), Gaps = 30/263 (11%) Query: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 G L +CS D IK++EV GE + + T GH V D GT S +YD + Sbjct: 235 GHLLLSCSMDCKIKLWEVYGE-RRCLRTFIGHSKAV--RDICFNTAGTQFLSAAYDRYLK 291 Query: 81 IWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS-SDGKVSVVEFKENGTTSPI 139 +W E G Q + V++ P E L VA SD K+ + + Sbjct: 292 LWDTETG---QCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQE- 347 Query: 140 IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQ-TYVLES 198 D H VN+ + E+R+FV+ D +++W+++ Y+ E Sbjct: 348 -YDRHLGAVNTIVF-------------VDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEP 393 Query: 199 TLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLW 258 ++ HS + V SP +LA S D +I+ N KK + K Sbjct: 394 SM--HS--MPAVTLSPN---GKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYAC 446 Query: 259 RASWSLSGNVLALSGGDNKVTLW 281 + +S + + G+ K+ +W Sbjct: 447 QVDFSPDMSYVISGDGNGKLNIW 469 >5YZG-W nrPDB Length = 579 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 64/263 (24%), Positives = 104/263 (39%), Gaps = 30/263 (11%) Query: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 G L +CS D IK++EV GE + + T GH V D GT S +YD + Sbjct: 301 GHLLLSCSMDCKIKLWEVYGE-RRCLRTFIGHSKAV--RDICFNTAGTQFLSAAYDRYLK 357 Query: 81 IWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS-SDGKVSVVEFKENGTTSPI 139 +W E G Q + V++ P E L VA SD K+ + + Sbjct: 358 LWDTETG---QCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQE- 413 Query: 140 IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQ-TYVLES 198 D H VN+ + E+R+FV+ D +++W+++ Y+ E Sbjct: 414 -YDRHLGAVNTIVF-------------VDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEP 459 Query: 199 TLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLW 258 ++ HS + V SP +LA S D +I+ N KK + K Sbjct: 460 SM--HS--MPAVTLSPN---GKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYAC 512 Query: 259 RASWSLSGNVLALSGGDNKVTLW 281 + +S + + G+ K+ +W Sbjct: 513 QVDFSPDMSYVISGDGNGKLNIW 535 >3C9C-A nrPDB Length = 432 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 87/214 (40%), Gaps = 43/214 (20%) Query: 49 LTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK-----EENGRWSQIAVHAVHSASVN 103 L GH+ + + W +P L S S D + +W +E+ + H+A V Sbjct: 179 LRGHQKEGYGLSW-NPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVE 237 Query: 104 SVQW-APHEYGPLLLVASSDGKVSVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEED 161 V W HE L + D K+ + + + N T+ P +DAH VN S+ P + Sbjct: 238 DVAWHLLHE--SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS---- 291 Query: 162 GEHNGTKESRKFV--TGGADNLVKIWKYNSDAQTYVLE-STLEGHSDWVRDVAWSPTVLL 218 +F+ TG AD V +W D + L+ + E H D + V WSP Sbjct: 292 ----------EFILATGSADKTVALW----DLRNLKLKLHSFESHKDEIFQVQWSPHN-- 335 Query: 219 RSYLASVSQDRTCIIW----------TQDNEQGP 242 + LAS DR +W T+D E GP Sbjct: 336 ETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGP 369 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 34/123 (27%), Positives = 60/123 (48%), Gaps = 17/123 (13%) Query: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 LAT S+DKT+ ++++ KL + H+ +++V W+ P TILAS D ++ +W Sbjct: 295 LATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWS-PHNETILASSGTDRRLHVWD 352 Query: 84 ------------EENGRWSQIAVHAVHSASVNSVQWAPHEYGP-LLLVASSDGKVSVVEF 130 E+G + +H H+A ++ W P+E P ++ S D + V + Sbjct: 353 LSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNE--PWIICSVSEDNIMQVWQM 410 Query: 131 KEN 133 EN Sbjct: 411 AEN 413 >3CFV-B nrPDB Length = 414 Score = 48.1 bits (113), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 61/212 (28%), Positives = 86/212 (40%), Gaps = 39/212 (18%) Query: 49 LTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENG-RWSQI----AVHAVHSASVN 103 L GH+ + + W G +L S S D V +W G + +I A+ HSA V Sbjct: 175 LRGHQKEGYGLSWNSNLSGHLL-SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVE 233 Query: 104 SVQW-APHEYGPLLLVASSDGKVSVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEED 161 V W HE L + D K+ + + + N T+ P ++DAH VN S+ P + Sbjct: 234 DVAWHLLHE--SLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYS---- 287 Query: 162 GEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLE-STLEGHSDWVRDVAWSPTVLLRS 220 TG AD V +W D + L+ T E H D + V WSP + Sbjct: 288 --------EFILATGSADKTVALW----DLRNLKLKLHTFESHKDEIFQVHWSPHN--ET 333 Query: 221 YLASVSQDRTCIIW----------TQDNEQGP 242 LAS DR +W +D E GP Sbjct: 334 ILASSGTDRRLNVWDLSKIGEEQSAEDAEDGP 365 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 37/144 (25%), Positives = 69/144 (47%), Gaps = 18/144 (12%) Query: 4 IANAHNELIHDAVLDYYGKR-LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 + +AH ++ + Y + LAT S+DKT+ ++++ KL T H+ +++V W+ Sbjct: 270 LVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL-HTFESHKDEIFQVHWS 328 Query: 63 HPKFGTILASCSYDGKVLIWK------------EENGRWSQIAVHAVHSASVNSVQWAPH 110 P TILAS D ++ +W E+G + +H H+A ++ W P+ Sbjct: 329 -PHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPN 387 Query: 111 EYGP-LLLVASSDGKVSVVEFKEN 133 E P ++ S D + + + EN Sbjct: 388 E--PWVICSVSEDNIMQIWQMAEN 409 >5Y1U-A nrPDB Length = 456 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 70/274 (25%), Positives = 107/274 (39%), Gaps = 55/274 (20%) Query: 49 LTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIW-----KEENGRWSQIAVHAVHSASVN 103 L GH+ + + W +P L S S D + +W +E + H+A V Sbjct: 204 LRGHQKEGYGLSW-NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVE 262 Query: 104 SVQW-APHEYGPLLLVASSDGKVSVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEED 161 V W HE L + D K+ + + + N T+ P +DAH VN S+ P + Sbjct: 263 DVSWHLLHES--LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS---- 316 Query: 162 GEHNGTKESRKFV--TGGADNLVKIWKYNSDAQTYVLE-STLEGHSDWVRDVAWSPTVLL 218 +F+ TG AD V +W D + L+ + E H D + V WSP Sbjct: 317 ----------EFILATGSADKTVALW----DLRNLKLKLHSFESHKDEIFQVQWSPHN-- 360 Query: 219 RSYLASVSQDRTCIIW----------TQDNEQGPWKKTLL---KEEKFPDVLWRAS--WS 263 + LAS DR +W +D E GP + + K D W + W Sbjct: 361 ETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW- 419 Query: 264 LSGNVLALSGGDNKVTLWK--ENLEGKWEPAGEV 295 V+ DN + +W+ EN+ +P G V Sbjct: 420 ----VICSVSEDNIMQVWQMAENIYNDEDPEGSV 449 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 34/123 (27%), Positives = 60/123 (48%), Gaps = 17/123 (13%) Query: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 LAT S+DKT+ ++++ KL + H+ +++V W+ P TILAS D ++ +W Sbjct: 320 LATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWS-PHNETILASSGTDRRLNVWD 377 Query: 84 ------------EENGRWSQIAVHAVHSASVNSVQWAPHEYGP-LLLVASSDGKVSVVEF 130 E+G + +H H+A ++ W P+E P ++ S D + V + Sbjct: 378 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE--PWVICSVSEDNIMQVWQM 435 Query: 131 KEN 133 EN Sbjct: 436 AEN 438 >6EOJ-D nrPDB Length = 470 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 37/128 (28%), Positives = 56/128 (43%), Gaps = 7/128 (5%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 I AH E I D + TCS D +KI+ + + L+GH V DW H Sbjct: 172 IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV--LSGHHWDVKSCDW-H 228 Query: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 P+ G ++AS S D V +W +G + H +V ++ P + G LL+ S D Sbjct: 229 PEMG-LIASASKDNLVKLWDPRSGNCISSILKFKH--TVLKTRFQPTK-GNLLMAISKDK 284 Query: 124 KVSVVEFK 131 V + + Sbjct: 285 SCRVFDIR 292 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 33/110 (30%), Positives = 49/110 (44%), Gaps = 11/110 (10%) Query: 172 KFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTC 231 KFVT DN++KIW +++ Q E L GH V+ W P + L +AS S+D Sbjct: 191 KFVTCSDDNILKIWNFSNGKQ----ERVLSGHHWDVKSCDWHPEMGL---IASASKDNLV 243 Query: 232 IIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 +W D G ++LK + VL GN+L D ++ Sbjct: 244 KLW--DPRSGNCISSILKFKH--TVLKTRFQPTKGNLLMAISKDKSCRVF 289 >6GMH-W nrPDB Length = 305 Score = 46.2 bits (108), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 61/232 (26%), Positives = 90/232 (38%), Gaps = 65/232 (28%) Query: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 + T S D +K+++ E L +L GH+ V VD +H I AS S D + +W Sbjct: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTL--PIAASSSLDAHIRLWD 92 Query: 84 EENGRW-------------------SQIAVHAVHSASVN--SVQWAPHEY-----GPLLL 117 ENG+ SQ H VN V+ EY G +L Sbjct: 93 LENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFIL 152 Query: 118 --VASSDGKVSVVEFKENGTTSPII-------------IDAHAIGVNSASWAPATIEEDG 162 S DGK + +G II ++ HA+ + S +++P Sbjct: 153 SIAYSPDGK-----YLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP------- 200 Query: 163 EHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSP 214 +S+ VT D +KI+ D Q L TL GH+ WV +VA+ P Sbjct: 201 ------DSQLLVTASDDGYIKIY----DVQHANLAGTLSGHASWVLNVAFCP 242 Score = 32.0 bits (71), Expect = 0.30, Method: Compositional matrix adjust. Identities = 36/117 (30%), Positives = 53/117 (45%), Gaps = 10/117 (8%) Query: 165 NGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLAS 224 N + S VTG D+LVK+WK+ + L+ +LEGH V V S T+ + AS Sbjct: 27 NKKENSETVVTGSLDDLVKVWKWRD--ERLDLQWSLEGHQLGVVSVDISHTLPIA---AS 81 Query: 225 VSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 S D +W D E G K++ + P W ++S LA KV ++ Sbjct: 82 SSLDAHIRLW--DLENGKQIKSI---DAGPVDAWTLAFSPDSQYLATGTHVGKVNIF 133 >5FVM-C nrPDB Length = 303 Score = 45.8 bits (107), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 53/217 (24%), Positives = 88/217 (40%), Gaps = 35/217 (16%) Query: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 + + S D TIK+++V + + H PV V HP G ++ SC DG + IW Sbjct: 90 MVSSSEDGTIKVWDVRSPS---VQRNYKHNAPVNEVA-IHPNQGELI-SCDQDGNIRIWD 144 Query: 84 EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLL-LVASSDGKVSVVEFKENGTTSPIIID 142 + + Q P + PL L +SDG + +V G + Sbjct: 145 LGENQCTN--------------QLTPEDNTPLQSLSVASDGSM-LVAGNNKGNCYVWRMP 189 Query: 143 AHAIGVNSASWAPATIEEDGEHNGTK-----ESRKFVTGGADNLVKIWKYNSDAQTYVLE 197 H ++++ P T + T+ + + T AD+ ++W + Y LE Sbjct: 190 HH---TDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDN---YQLE 243 Query: 198 STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 +TL+GH WV D A+S +YL + D +W Sbjct: 244 TTLDGHQRWVWDCAFSAD---SAYLVTACSDHYVRLW 277 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 25/76 (32%), Positives = 39/76 (51%), Gaps = 3/76 (3%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 +H + I +L K LATCS+D T +++ +E + ++L TL GH+ VW D A Sbjct: 205 SHTKYITRVLLSADVKNLATCSADHTARVWNIE-DNYQLETTLDGHQRWVW--DCAFSAD 261 Query: 67 GTILASCSYDGKVLIW 82 L + D V +W Sbjct: 262 SAYLVTACSDHYVRLW 277 Score = 31.2 bits (69), Expect = 0.62, Method: Compositional matrix adjust. Identities = 47/217 (21%), Positives = 81/217 (37%), Gaps = 30/217 (13%) Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 ILAS YD + W+ G S+ HA + VN ++ + L A+ V Sbjct: 1 MSVILASAGYDHTIRFWEALTGVCSRTIQHA--DSQVNRLEITSDKK---YLAAAGHLHV 55 Query: 126 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 + + + N + H V S ++ +E+R V+ D +K+W Sbjct: 56 RLYDIRSNNPNPVSSFEGHKGNVTSIAFQ-------------QENRWMVSSSEDGTIKVW 102 Query: 186 KYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKK 245 D ++ ++ + H+ V +VA P + L S QD IW D + Sbjct: 103 ----DVRSPSVQRNYK-HNAPVNEVAIHPN---QGELISCDQDGNIRIW--DLGENQCTN 152 Query: 246 TLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 L E+ P L S + G++L +W+ Sbjct: 153 QLTPEDNTP--LQSLSVASDGSMLVAGNNKGNCYVWR 187 >5A9Q-2 nrPDB Length = 326 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 31/97 (31%), Positives = 45/97 (46%), Gaps = 9/97 (9%) Query: 144 HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGH 203 H + V+ +W+P T + KF T AD +KI + SD Q LEGH Sbjct: 71 HGVRVDGIAWSPET-----RLDSLPPVIKFCTSAAD--MKIRLFTSDLQDKNEYKVLEGH 123 Query: 204 SDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 +D++ + + P +ASVS D TC IW + Q Sbjct: 124 TDFINGLVFDPKE--GQEIASVSDDHTCRIWNLEGVQ 158 Score = 32.0 bits (71), Expect = 0.35, Method: Compositional matrix adjust. Identities = 33/132 (25%), Positives = 57/132 (43%), Gaps = 8/132 (6%) Query: 23 RLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIW 82 + T ++D I++F + + L GH + + + PK G +AS S D IW Sbjct: 94 KFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVF-DPKEGQEIASVSDDHTCRIW 152 Query: 83 KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIID 142 E Q A +HS + SV W P E L+VA +G + + + + ++ Sbjct: 153 NLEG---VQTAHFVLHSPGM-SVCWHPEETFK-LMVAEKNGTIRFYDLL--AQQAILSLE 205 Query: 143 AHAIGVNSASWA 154 + + + SA W Sbjct: 206 SEQVPLMSAHWC 217 >5FL8-q nrPDB Length = 515 Score = 45.1 bits (105), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 70/295 (23%), Positives = 108/295 (36%), Gaps = 67/295 (22%) Query: 23 RLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIW 82 RLA+ S D TIKI++ + T++GH V V W +L S S+D V +W Sbjct: 250 RLASSSKDGTIKIWDTVSRVCQY--TMSGHTNSVSCVKWGGQG---LLYSGSHDRTVRVW 304 Query: 83 KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVE------------- 129 + N + I + H+ VN + + + + K S E Sbjct: 305 -DINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKI 363 Query: 130 FKENGTTSPIIIDA-----------------------HAIGVNSASWAPATIEEDGEHNG 166 K+NG + +++ A H VN +++P Sbjct: 364 CKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSP----------- 412 Query: 167 TKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVS 226 + R V+ DN +K+W D + ST GH V VAWS L L S S Sbjct: 413 --DGRYIVSASFDNSIKLW----DGRDGKFISTFRGHVASVYQVAWSSDCRL---LVSCS 463 Query: 227 QDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 +D T +W +K + D ++ WS+ G + G D V LW Sbjct: 464 KDTTLKVWDVRT-----RKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 33/106 (31%), Positives = 46/106 (43%), Gaps = 19/106 (17%) Query: 135 TTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTY 194 T S I H + +++AP T S + VTG DN +IW D T Sbjct: 133 TRSSSAIAGHGSTILCSAFAPHT------------SSRMVTGAGDNTARIW----DCDTQ 176 Query: 195 VLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 TL+GH +WV V+WSP +A+ S D T +W + Q Sbjct: 177 TPMHTLKGHYNWVLCVSWSPD---GEVIATGSMDNTIRLWDPKSGQ 219 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 39/144 (27%), Positives = 60/144 (41%), Gaps = 25/144 (17%) Query: 96 AVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI-IIDAHAIGVNSASWA 154 A H +++ +APH ++ A + + T +P+ + H V SW+ Sbjct: 140 AGHGSTILCSAFAPHTSSRMVTGAGDN----TARIWDCDTQTPMHTLKGHYNWVLCVSWS 195 Query: 155 PATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSP 214 P DGE TG DN +++W S L L GHS W+ ++W P Sbjct: 196 P-----DGE--------VIATGSMDNTIRLWDPKSGQ---CLGDALRGHSKWITSLSWEP 239 Query: 215 TVLL----RSYLASVSQDRTCIIW 234 L+ + LAS S+D T IW Sbjct: 240 IHLVKPGSKPRLASSSKDGTIKIW 263 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 50/103 (48%), Gaps = 8/103 (7%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H +L++ G+ + + S D +IK+++ G K I T GH V++V W+ Sbjct: 400 GHQKLVNHVAFSPDGRYIVSASFDNSIKLWD--GRDGKFISTFRGHVASVYQVAWSSD-- 455 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAV-HSASVNSVQWA 108 +L SCS D + +W + R +++V H V +V W+ Sbjct: 456 CRLLVSCSKDTTLKVW---DVRTRKLSVDLPGHKDEVYTVDWS 495 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 39/164 (23%), Positives = 71/164 (43%), Gaps = 22/164 (13%) Query: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 + T S D T+ ++ T K I +TGH+ V V A G + S S+D + +W Sbjct: 374 MVTASDDYTMFLWNPLKST-KPIARMTGHQKLVNHV--AFSPDGRYIVSASFDNSIKLWD 430 Query: 84 EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDA 143 +G++ I+ H ASV V W+ LL+ S D + V + + + + + Sbjct: 431 GRDGKF--ISTFRGHVASVYQVAWSSDCR--LLVSCSKDTTLKVWDVRTRKLS--VDLPG 484 Query: 144 HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 H V + W+ + ++ +GG D +V++W + Sbjct: 485 HKDEVYTVDWS-------------VDGKRVCSGGKDKMVRLWTH 515 Score = 37.4 bits (85), Expect = 0.007, Method: Compositional matrix adjust. Identities = 51/209 (24%), Positives = 87/209 (41%), Gaps = 26/209 (12%) Query: 35 IFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAV 94 +F+V+ T + + GH + +A P + + + + D IW + +Q + Sbjct: 126 VFKVKPVT-RSSSAIAGHGSTILCSAFA-PHTSSRMVTGAGDNTARIWDCD----TQTPM 179 Query: 95 HAV--HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSAS 152 H + H V V W+P G ++ S D + + + K +G + H+ + S S Sbjct: 180 HTLKGHYNWVLCVSWSPD--GEVIATGSMDNTIRLWDPK-SGQCLGDALRGHSKWITSLS 236 Query: 153 WAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAW 212 W P + + G + + D +KIW D + V + T+ GH++ V V W Sbjct: 237 WEPIHLVKPGSKP------RLASSSKDGTIKIW----DTVSRVCQYTMSGHTNSVSCVKW 286 Query: 213 SPTVLLRSYLASVSQDRTCIIWTQDNEQG 241 LL S S DRT +W N QG Sbjct: 287 GGQGLLYSG----SHDRTVRVW-DINSQG 310 >6G51-g nrPDB Length = 317 Score = 44.3 bits (103), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 65/254 (25%), Positives = 104/254 (40%), Gaps = 37/254 (14%) Query: 41 ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK----EENGRWSQIAVHA 96 E L TL GH G V ++ P+F ++ S S D +++WK E N Q A+ Sbjct: 3 EQMTLRGTLKGHNGWVTQIA-TTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 Query: 97 VHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPA 156 HS V+ V + G L S DG + + + TT + H V S +++ Sbjct: 62 -HSHFVSDVVISSD--GQFALSGSWDGTLRLWDLTTGTTTRRFV--GHTKDVLSVAFS-- 114 Query: 157 TIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV 216 ++R+ V+G D +K+W + V + E HS+WV V +SP Sbjct: 115 -----------SDNRQIVSGSRDKTIKLWNTLGVCKYTVQD---ESHSEWVSCVRFSPNS 160 Query: 217 LLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLS--GNVLALSGG 274 + S D+ +W N + LK + + ++S G++ A G Sbjct: 161 -SNPIIVSCGWDKLVKVWNLANCK-------LKTNHIGHTGYLNTVTVSPDGSLCASGGK 212 Query: 275 DNKVTLWKENLEGK 288 D + LW N EGK Sbjct: 213 DGQAMLWDLN-EGK 225 Score = 28.5 bits (62), Expect = 3.3, Method: Compositional matrix adjust. Identities = 59/283 (20%), Positives = 100/283 (35%), Gaps = 39/283 (13%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H+ + D V+ G+ + S D T++++++ T GH V V A Sbjct: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLT--TGTTTRRFVGHTKDVLSV--AFSSD 116 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 + S S D + +W G HS V+ V+++P+ P+++ D V Sbjct: 117 NRQIVSGSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 Query: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 V + I H +N+ + +P DG +GG D +W Sbjct: 176 VWNLANCKLKTNHI--GHTGYLNTVTVSP-----DGS--------LCASGGKDGQAMLWD 220 Query: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT 246 N Y L+ D + + +SP Y + + IW + +G Sbjct: 221 LNEGKHLYTLDG-----GDIINALCFSP----NRYWLCAATGPSIKIW---DLEGKIIVD 268 Query: 247 LLKEEKF-------PDVLWRASWSLSGNVLALSGGDNKVTLWK 282 LK+E P +WS G L DN V +W+ Sbjct: 269 ELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 >4V6W-Ag nrPDB Length = 318 Score = 43.9 bits (102), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 63/253 (24%), Positives = 105/253 (41%), Gaps = 34/253 (13%) Query: 41 ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK-----EENGRWSQIAVH 95 ET +L TL GH G V ++ +PK + S S D +++WK + N + Q ++ Sbjct: 3 ETLQLRGTLIGHNGWVTQIA-TNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLY 61 Query: 96 AVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAP 155 HS ++ V + G L S D + + + TT + H V S +++ Sbjct: 62 G-HSHFISDVVLSSD--GNYALSGSWDQTLRLWDLAAGKTTRRF--EGHTKDVLSVAFSA 116 Query: 156 ATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPT 215 ++R+ V+G D +K+W ++ + + E +GH+DWV V +SP Sbjct: 117 -------------DNRQIVSGSRDKTIKLWNTLAECKFTIQE---DGHTDWVSCVRFSPN 160 Query: 216 VLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGD 275 + S DRT +W N K L + S G++ G D Sbjct: 161 -HSNPIIVSCGWDRTVKVWNLAN-----CKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKD 214 Query: 276 NKVTLWKENLEGK 288 +K LW N +GK Sbjct: 215 SKALLWDLN-DGK 226 Score = 33.9 bits (76), Expect = 0.082, Method: Compositional matrix adjust. Identities = 68/302 (22%), Positives = 114/302 (37%), Gaps = 77/302 (25%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE-GETHKLIDTLTGHEGPVWRVDWAHPK 65 H+ I D VL G + S D+T++++++ G+T + + GH V V A Sbjct: 62 GHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFE---GHTKDVLSV--AFSA 116 Query: 66 FGTILASCSYDGKVLIWK---------EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLL 116 + S S D + +W +E+G H+ V+ V+++P+ P++ Sbjct: 117 DNRQIVSGSRDKTIKLWNTLAECKFTIQEDG----------HTDWVSCVRFSPNHSNPII 166 Query: 117 LVASSDGKVSV-----VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESR 171 + D V V + K N H +N+ + +P DG Sbjct: 167 VSCGWDRTVKVWNLANCKLKNNH-------HGHNGYLNTVTVSP-----DGS-------- 206 Query: 172 KFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTC 231 +GG D+ +W N Y LE H+D + + +SP Y V+ + Sbjct: 207 LCTSGGKDSKALLWDLNDGKNLYTLE-----HNDIINALCFSP----NRYWLCVAYGPSI 257 Query: 232 IIWTQDNEQGPWKKTLLKEEKFPDVLWRAS-----------WSLSGNVLALSGGDNKVTL 280 IW KKT+ EE P+V+ S WS G L DN + + Sbjct: 258 KIWDL-----ACKKTV--EELRPEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNTIRV 310 Query: 281 WK 282 W+ Sbjct: 311 WQ 312 Score = 32.0 bits (71), Expect = 0.35, Method: Compositional matrix adjust. Identities = 33/97 (34%), Positives = 46/97 (47%), Gaps = 13/97 (13%) Query: 191 AQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT----QDNEQGPWKKT 246 ++T L TL GH+ WV +A +P + S S+D+T I+W +D G +K Sbjct: 2 SETLQLRGTLIGHNGWVTQIATNPKD--PDTIISASRDKTLIVWKLTRDEDTNYGYPQKR 59 Query: 247 LLKEEKF-PDVLWRASWSLSGNVLALSGG-DNKVTLW 281 L F DV+ S GN ALSG D + LW Sbjct: 60 LYGHSHFISDVV----LSSDGN-YALSGSWDQTLRLW 91 >6F3T-A nrPDB Length = 608 Score = 43.9 bits (102), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 56/237 (23%), Positives = 87/237 (36%), Gaps = 35/237 (14%) Query: 46 IDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSV 105 + L GH GPV+ ++ + L S S DG V +W + ++ + + H+ V Sbjct: 344 LKILYGHSGPVYGASFSPDR--NYLLSSSEDGTVRLWSLQT--FTCLVGYKGHNYPVWDT 399 Query: 106 QWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEEDGEH 164 Q++P+ Y S G V P+ I H VN + P Sbjct: 400 QFSPYGY-----YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHP--------- 445 Query: 165 NGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLAS 224 S TG AD V++W D GH + + +SP +LA+ Sbjct: 446 ----NSNYVATGSADRTVRLW----DVLNGNCVRIFTGHKGPIHSLTFSPN---GRFLAT 494 Query: 225 VSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 + D ++W D G L + D + +S G +LA DN V LW Sbjct: 495 GATDGRVLLW--DIGHGLMVGEL---KGHTDTVCSLRFSRDGEILASGSMDNTVRLW 546 Score = 38.5 bits (88), Expect = 0.003, Method: Compositional matrix adjust. Identities = 29/104 (27%), Positives = 57/104 (54%), Gaps = 8/104 (7%) Query: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 +AT S+D+T+++++V + TGH+GP+ + ++ P G LA+ + DG+VL+W Sbjct: 450 VATGSADRTVRLWDVLNGN--CVRIFTGHKGPIHSLTFS-PN-GRFLATGATDGRVLLW- 504 Query: 84 EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 + G + H+ +V S++++ G +L S D V + Sbjct: 505 -DIGHGLMVGELKGHTDTVCSLRFS--RDGEILASGSMDNTVRL 545 >4XYI-A nrPDB Length = 430 Score = 43.9 bits (102), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 31/117 (26%), Positives = 55/117 (47%), Gaps = 15/117 (12%) Query: 7 AHNELIHDAVLDYYGKRL-ATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 AH + ++ + + L AT S+D T+ ++++ +L TL GHE V+ V W+ P Sbjct: 279 AHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRL-HTLEGHEDEVYNVQWS-PH 336 Query: 66 FGTILASCSYDGKVLIW------------KEENGRWSQIAVHAVHSASVNSVQWAPH 110 IL + S D +V +W E+G + +H H+ V+ + W P+ Sbjct: 337 DEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPN 393 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 47/195 (24%), Positives = 81/195 (41%), Gaps = 28/195 (14%) Query: 49 LTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK--------EENGRWSQIAVHAVHSA 100 L H + + W + GT LA+ + D + +W E++ + ++V+ H+A Sbjct: 178 LRHHTSEGFGLGWNFIQEGT-LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTA 236 Query: 101 SVNSVQWAPHEYGPLLLVASSDGKVSVVEFK-ENGTTSPIIIDAHAIGVNSASWAPATIE 159 VN +Q+ ++ LL S D + + + + + +++ + AH VN ++ P Sbjct: 237 VVNDLQFH-LQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFN-- 293 Query: 160 EDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLR 219 T AD+ V +W Q TLEGH D V +V WSP Sbjct: 294 ----------DYLLATASADHTVALWDLRRLNQRL---HTLEGHEDEVYNVQWSPHD--E 338 Query: 220 SYLASVSQDRTCIIW 234 L + S DR +W Sbjct: 339 PILVTSSTDRRVCVW 353 >6HQA-B nrPDB Length = 722 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 59/234 (25%), Positives = 92/234 (39%), Gaps = 34/234 (14%) Query: 49 LTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWA 108 L GH G V+ VD++ P L SCS D V +W + ++ + + HS+SV V+++ Sbjct: 449 LVGHSGAVYGVDFS-PD-NRYLISCSEDKTVRLWSLDT--YTCLVSYKGHSSSVWDVKFS 504 Query: 109 PHEYGPLLLVASSDGKVSVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEEDGEHNGT 167 P G AS D + P+ I H V+ + P Sbjct: 505 P--MGHYFATASHDQTARLWSCDH---IYPLRIFAGHLNDVDCVEFHP------------ 547 Query: 168 KESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQ 227 S TG +D ++W D GHS + +A SP +LAS + Sbjct: 548 -NSTYLFTGSSDKTARMW----DIARGECVRVFMGHSGAINCLAVSPD---GRWLASAGE 599 Query: 228 DRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 D +W D G K + + ++ ++S G VL +G DN V +W Sbjct: 600 DSVVCLW--DISTGRRIKAMRGHGR--SSIYSLAFSREGTVLVSTGADNSVRVW 649 >5Y88-O nrPDB Length = 451 Score = 43.1 bits (100), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 28/68 (41%), Positives = 36/68 (52%), Gaps = 7/68 (10%) Query: 173 FVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 232 F+TG D +K+W D T L++TL GH VRDVA S YL SVS+D+T Sbjct: 155 FITGSNDTTMKVW----DLATGKLKTTLAGHVMTVRDVAVSDR---HPYLFSVSEDKTVK 207 Query: 233 IWTQDNEQ 240 W + Q Sbjct: 208 CWDLEKNQ 215 >6MZM-G nrPDB Length = 800 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 56/234 (23%), Positives = 86/234 (36%), Gaps = 35/234 (14%) Query: 49 LTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWA 108 L GH GPV+ ++ + L S S DG V +W + ++ + + H+ V Q++ Sbjct: 539 LYGHSGPVYGASFSPDR--NYLLSSSEDGTVRLWSLQT--FTCLVGYKGHNYPVWDTQFS 594 Query: 109 PHEYGPLLLVASSDGKVSVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEEDGEHNGT 167 P+ Y S G V P+ I H VN + P Sbjct: 595 PYGY-----YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHP------------ 637 Query: 168 KESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQ 227 S TG AD V++W D GH + + +SP +LA+ + Sbjct: 638 -NSNYVATGSADRTVRLW----DVLNGNCVRIFTGHKGPIHSLTFSPN---GRFLATGAT 689 Query: 228 DRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 D ++W D G L + D + +S G +LA DN V LW Sbjct: 690 DGRVLLW--DIGHGLMVGEL---KGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738 Score = 38.5 bits (88), Expect = 0.003, Method: Compositional matrix adjust. Identities = 29/104 (27%), Positives = 57/104 (54%), Gaps = 8/104 (7%) Query: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 +AT S+D+T+++++V + TGH+GP+ + ++ P G LA+ + DG+VL+W Sbjct: 642 VATGSADRTVRLWDVL--NGNCVRIFTGHKGPIHSLTFS-PN-GRFLATGATDGRVLLW- 696 Query: 84 EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 + G + H+ +V S++++ G +L S D V + Sbjct: 697 -DIGHGLMVGELKGHTDTVCSLRFS--RDGEILASGSMDNTVRL 737 >6QX9-4B nrPDB Length = 522 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 62/249 (24%), Positives = 97/249 (38%), Gaps = 48/249 (19%) Query: 45 LIDTLTGHEGPVWRVDWAHPKFGTI--------LASCSYDGKVLIWKEENGRWSQIAVHA 96 L+ TL GH V + + HPK T+ LASC+ DG V +W ++ +A Sbjct: 265 LLHTLRGHNTNVGAIVF-HPK-STVSLDPKDVNLASCAADGSVKLWSLDSD--EPVADIE 320 Query: 97 VHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPA 156 H+ V V W H G L D + + + + + H++GV ++ Sbjct: 321 GHTVRVARVMW--HPSGRFLGTTCYDRSWRLWDLE--AQEEILHQEGHSMGVYDIAF--- 373 Query: 157 TIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV 216 +DG G TGG D ++W D +T LEGH + + +SP Sbjct: 374 --HQDGSLAG--------TGGLDAFGRVW----DLRTGRCIMFLEGHLKEIYGINFSPNG 419 Query: 217 LLRSYLASVSQDRTCIIWTQDNEQG----PWKKTLLKEEKFPDVLWRASWSLSGNVLALS 272 ++A+ S D TC +W + P + L+ KF + GN L Sbjct: 420 Y---HIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPI--------HGNFLLTG 468 Query: 273 GGDNKVTLW 281 DN +W Sbjct: 469 AYDNTAKIW 477 Score = 35.8 bits (81), Expect = 0.021, Method: Compositional matrix adjust. Identities = 27/80 (33%), Positives = 40/80 (50%), Gaps = 5/80 (6%) Query: 7 AHNELIHDAVLD-YYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 AH L+ + +G L T + D T KI+ G + + TL GHEG V +D + Sbjct: 447 AHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSP--LKTLAGHEGKVMGLDISSD- 503 Query: 66 FGTILASCSYDGKVLIWKEE 85 G ++A+CSYD +W E Sbjct: 504 -GQLIATCSYDRTFKLWMAE 522 Score = 31.6 bits (70), Expect = 0.46, Method: Compositional matrix adjust. Identities = 48/217 (22%), Positives = 81/217 (37%), Gaps = 29/217 (13%) Query: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 G+ L T D++ +++++E + L GH V+ D A + G++ + D Sbjct: 335 GRFLGTTCYDRSWRLWDLEAQEEILHQE--GHSMGVY--DIAFHQDGSLAGTGGLDAFGR 390 Query: 81 IWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII 140 +W GR I H + + ++P+ Y + S D V + ++ Sbjct: 391 VWDLRTGRC--IMFLEGHLKEIYGINFSPNGYH--IATGSGDNTCKVWDLRQRRCV--YT 444 Query: 141 IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTL 200 I AH V + P +TG DN KIW + + TL Sbjct: 445 IPAHQNLVTGVKFEPI------------HGNFLLTGAYDNTAKIWTHPG----WSPLKTL 488 Query: 201 EGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQD 237 GH V + S L +A+ S DRT +W + Sbjct: 489 AGHEGKVMGLDISSDGQL---IATCSYDRTFKLWMAE 522 >3DM0-A nrPDB Length = 694 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 35/120 (29%), Positives = 57/120 (47%), Gaps = 8/120 (6%) Query: 169 ESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQD 228 ++R+ V+ D +K+W + + Y + EGH DWV V +SP L+ + S S D Sbjct: 483 DNRQIVSASRDRTIKLWNTLGECK-YTISEGGEGHRDWVSCVRFSPNT-LQPTIVSASWD 540 Query: 229 RTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGK 288 +T +W N + + TL + + + S G++ A G D V LW + EGK Sbjct: 541 KTVKVWNLSNCK--LRSTLAGHTGYVSTV---AVSPDGSLCASGGKDGVVLLW-DLAEGK 594 >5WYJ-BC nrPDB Length = 817 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 26/68 (38%), Positives = 37/68 (54%), Gaps = 4/68 (5%) Query: 20 YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKV 79 Y K LAT S DKT+KI+ + +T ++ TL GH V R + + + L SC DG + Sbjct: 544 YDKLLATSSGDKTVKIWSL--DTFSVMKTLEGHTNAVQRCSFINKQ--KQLISCGADGLI 599 Query: 80 LIWKEENG 87 IW +G Sbjct: 600 KIWDCSSG 607 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 67/273 (24%), Positives = 115/273 (42%), Gaps = 39/273 (14%) Query: 29 SDKTIKIFEVEGE------THKLIDTLTGHEGPVWRVDWAHPKFGTI-LASCSYDGKVLI 81 SD+T+++ VE + T ++ ++ G+ G + + + P+ + LA+ S +++ Sbjct: 307 SDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIP 366 Query: 82 WKEENGRWS----QIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTS 137 + +G + + ++ H +NS+ E G + AS D V + EN Sbjct: 367 VPDLSGPEASLPLDVEIYEGHEDLLNSLDAT--EDGLWIATASKDNTAIVWRYNENSCKF 424 Query: 138 PIIIDAHAIGVNSASWA---PATIEEDGEHNGTKESRKFVTGGADNLVKIW-----KYNS 189 I A IG ++A A P + + G E +T D +K W + Sbjct: 425 DIY--AKYIGHSAAVTAVGLPNIVSK-----GYPEF--LLTASNDLTIKKWIIPKPTASM 475 Query: 190 DAQTY-VLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLL 248 D Q V E T H + ++ SP S A+ S D+TC IW +N G + TL Sbjct: 476 DVQIIKVSEYTRHAHEKDINALSVSPN---DSIFATASYDKTCKIWNLEN--GELEATLA 530 Query: 249 KEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 ++ LW S+ +LA S GD V +W Sbjct: 531 NHKRG---LWDVSFCQYDKLLATSSGDKTVKIW 560 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 69/311 (22%), Positives = 120/311 (38%), Gaps = 62/311 (19%) Query: 23 RLATCSSDKTIKIFEV------EGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYD 76 +LA ++ +++I V E ++ GHE + +D G +A+ S D Sbjct: 352 KLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATED--GLWIATASKD 409 Query: 77 GKVLIWK--EENGRWSQIAVHAVHSASVNSV---QWAPHEYGPLLLVASSDGKVS--VVE 129 ++W+ E + ++ A + HSA+V +V Y LL AS+D + ++ Sbjct: 410 NTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIP 469 Query: 130 FKENGTTSPII-------------IDAHAIGVNSASWAPATIE--------EDGEHNGTK 168 II I+A ++ N + +A A+ + E+GE T Sbjct: 470 KPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATL 529 Query: 169 ESRK--------------FVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSP 214 + K T D VKIW + T+ + TLEGH++ V+ ++ Sbjct: 530 ANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLD----TFSVMKTLEGHTNAVQRCSF-- 583 Query: 215 TVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGG 274 + + L S D IW D G KTL + + LW S G+++ + Sbjct: 584 -INKQKQLISCGADGLIKIW--DCSSGECLKTL---DGHNNRLWALSTMNDGDMIVSADA 637 Query: 275 DNKVTLWKENL 285 D WK+ Sbjct: 638 DGVFQFWKDCT 648 Score = 28.5 bits (62), Expect = 3.5, Method: Compositional matrix adjust. Identities = 37/172 (21%), Positives = 80/172 (46%), Gaps = 22/172 (12%) Query: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 G+ L S + +KIF ++ T K++ ++ P + +D T+LA DG ++ Sbjct: 73 GQYLTYVSQAQLLKIFHLK--TGKVVRSMK-ISSPSYILDADST--STLLAVGGTDGSII 127 Query: 81 IWKEENGRWSQIAVHAV--HSASVNSVQWAPHEYGPLLLVASSD--GKVSVVEFKENGTT 136 + ENG + H+ H +++S+++ + L+AS D G V V + + Sbjct: 128 VVDIENGYIT----HSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKC- 182 Query: 137 SPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN 188 H + ++++ I E +++ + S ++GG D+++ +W +N Sbjct: 183 ------LHTLQEHTSAVRGLDIIEVPDND--EPSLNLLSGGRDDIINLWDFN 226 >4XFV-A nrPDB Length = 792 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 61/247 (24%), Positives = 105/247 (42%), Gaps = 29/247 (11%) Query: 22 KRLATCSSDKTIKIFE-VEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 K++ + KTI +++ +E + TL GHE V V + + S S D V Sbjct: 31 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD--SDFMVSASEDHHVK 88 Query: 81 IWKEENGRWSQIAVHAVH-SASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI 139 IWK + Q H S ++ ++ P L+ V +DG +S+ +++N Sbjct: 89 IWKFTDYSHLQCIQTIQHYSKTIVALSALP----SLISVGCADGTISI--WRQNIQNDEF 142 Query: 140 IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFV--TGGADNLVKIWKY---NSDAQTY 194 + AH + + P + E +K++ GG + V I + +S + Sbjct: 143 GL-AHEFTIKKGFFYPLCLSL-----SKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKC 196 Query: 195 VLESTLEGHSDWVRDVAWSPTVLLRSY-LASVSQDRTCIIW-------TQDNEQGPWKKT 246 + + LEGH DWV+ +A+ Y L S SQDR +W D+E+ K T Sbjct: 197 RVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLT 256 Query: 247 LLKEEKF 253 LL +++ Sbjct: 257 LLSNKQY 263 Score = 34.3 bits (77), Expect = 0.071, Method: Compositional matrix adjust. Identities = 18/68 (26%), Positives = 32/68 (47%), Gaps = 2/68 (2%) Query: 221 YLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSL--SGNVLALSGGDNKV 278 +L SV +DR +W ++ E ++ E+ ++W A W+ GNV + D V Sbjct: 624 FLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTV 683 Query: 279 TLWKENLE 286 +W+ E Sbjct: 684 KVWRHQKE 691 Score = 32.7 bits (73), Expect = 0.21, Method: Compositional matrix adjust. Identities = 18/68 (26%), Positives = 32/68 (47%), Gaps = 6/68 (8%) Query: 183 KIWKYNSDAQTYV---LESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNE 239 K +K+ D + V E+ + GH DW+ + W + R L + + D + ++W D Sbjct: 261 KQYKFQIDDELRVGINFEALIMGHDDWISSLQWHES---RLQLLAATADTSLMVWEPDET 317 Query: 240 QGPWKKTL 247 G W +L Sbjct: 318 SGIWVCSL 325 Score = 30.8 bits (68), Expect = 0.84, Method: Compositional matrix adjust. Identities = 19/69 (27%), Positives = 32/69 (46%), Gaps = 3/69 (4%) Query: 21 GKRLATCSSDKTIKIFE--VEGETHKL-IDTLTGHEGPVWRVDWAHPKFGTILASCSYDG 77 GK L + D+ ++E +E T +L H +W DWA +FG + + S D Sbjct: 622 GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDK 681 Query: 78 KVLIWKEEN 86 V +W+ + Sbjct: 682 TVKVWRHQK 690 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 43/98 (43%), Gaps = 6/98 (6%) Query: 33 IKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK---EENGRW 89 I+IF E ++ L H + R+ ++ K G L S D K +W+ E+N Sbjct: 591 IRIFSTENWL-EIKPALPFHSLTITRLKFS--KDGKFLLSVCRDRKWALWERNMEDNTFE 647 Query: 90 SQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 + H+ + WAP E+G + + AS D V V Sbjct: 648 LRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKV 685 Score = 29.6 bits (65), Expect = 1.6, Method: Compositional matrix adjust. Identities = 43/189 (22%), Positives = 78/189 (41%), Gaps = 26/189 (13%) Query: 46 IDTLTGHEGPVWRVDWAHPKFGTILASCS----YDGKVLIWKEENGRWSQI-AVHAVHSA 100 ++ L GH + +D + P I ++C + + I+ EN W +I HS Sbjct: 555 VEKLYGHGFEITCLDIS-PDQKLIASACRSNNVQNAVIRIFSTEN--WLEIKPALPFHSL 611 Query: 101 SVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIID---AHAIGVNSASWAPAT 157 ++ ++++ G LL D K ++ E T + H + A WAP Sbjct: 612 TITRLKFSKD--GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLE 669 Query: 158 IEEDGEHNGTKESRKFVTGGADNLVKIWKYNSD-AQTYVLESTLEGHSDWVRDVAWSPTV 216 FVT D VK+W++ + A YVLE++++ H+ V ++ ++ Sbjct: 670 F-----------GNVFVTASRDKTVKVWRHQKEPADDYVLEASIK-HTKAVTAISIHDSM 717 Query: 217 LLRSYLASV 225 + L SV Sbjct: 718 IREKILISV 726 >3JB9-g nrPDB Length = 558 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 45/176 (25%), Positives = 81/176 (46%), Gaps = 38/176 (21%) Query: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 G L + S D IKI+EV + L+ T GH P+ D + + G S S+D + Sbjct: 279 GHLLLSGSMDNQIKIWEVYHD-RSLLRTFQGHARPIR--DLSFSQDGRSFLSTSFDKTIK 335 Query: 81 IWKEENGRWSQIAVHAVHSASV-NSVQWA-----PHEYGPLLLVASSDGKVSVVEFKENG 134 +W E G+ ++ +S + N V++ P+E+ L ++D ++ + + Sbjct: 336 LWDTELGK----CLNCFNSDRLTNCVKFQVDPDKPNEF----LAGTADKRILQFDIR--- 384 Query: 135 TTSPIII---DAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 SP I+ D H G+NS ++ E+G ++FVT D+ ++ W+Y Sbjct: 385 --SPDIVQAYDHHLGGINSITFL-----ENG--------KRFVTTSDDSSMRFWEY 425 Score = 35.4 bits (80), Expect = 0.026, Method: Compositional matrix adjust. Identities = 25/69 (36%), Positives = 38/69 (55%), Gaps = 8/69 (11%) Query: 173 FVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 232 ++G DN +KIW+ D L T +GH+ +RD+++S RS+L S S D+T Sbjct: 282 LLSGSMDNQIKIWEVYHDRS---LLRTFQGHARPIRDLSFSQDG--RSFL-STSFDKTIK 335 Query: 233 IWTQDNEQG 241 +W D E G Sbjct: 336 LW--DTELG 342 >6N9G-C nrPDB Length = 353 Score = 41.6 bits (96), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 41/192 (21%), Positives = 76/192 (39%), Gaps = 23/192 (11%) Query: 23 RLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIW 82 ++ T S D T +++VE + +L+ + GH V +D A + G S D K ++W Sbjct: 167 QILTASGDGTCALWDVE--SGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVW 224 Query: 83 KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIID 142 +G+ Q H + VNSV++ P G S D + + + + + + Sbjct: 225 DMRSGQCVQ--AFETHESDVNSVRYYPS--GDAFASGSDDATCRLYDLRADREVAIYSKE 280 Query: 143 AHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEG 202 + G +S ++ + R G D + +W ++ S L G Sbjct: 281 SIIFGASSVDFSLS-------------GRLLFAGYNDYTINVWDVLKGSRV----SILFG 323 Query: 203 HSDWVRDVAWSP 214 H + V + SP Sbjct: 324 HENRVSTLRVSP 335 Score = 35.8 bits (81), Expect = 0.021, Method: Compositional matrix adjust. Identities = 63/276 (22%), Positives = 99/276 (35%), Gaps = 65/276 (23%) Query: 48 TLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSAS--VNSV 105 TL GH V +DW K + S S DGKV++W ++ HAV V + Sbjct: 58 TLKGHGNKVLCMDWCKDK--RRIVSSSQDGKVIVWDS----FTTNKEHAVTMPCTWVMAC 111 Query: 106 QWAPHEYGPLLLVASSDGKVSVVEF----KENGTTSPIIIDAHAIGVNSASWAPATIE-- 159 +AP G + D K SV EN + H +++ S+ + ++ Sbjct: 112 AYAPS--GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQIL 169 Query: 160 -------------EDGE-------HNG---------TKESRKFVTGGADNLVKIWKYNSD 190 E G+ H ++ FV+GG D +W D Sbjct: 170 TASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVW----D 225 Query: 191 AQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW--TQDNEQGPWKKTLL 248 ++ E H V V + P+ AS S D TC ++ D E + K Sbjct: 226 MRSGQCVQAFETHESDVNSVRYYPS---GDAFASGSDDATCRLYDLRADREVAIYSK--- 279 Query: 249 KEEKFPDVLWRAS---WSLSGNVLALSGGDNKVTLW 281 +++ AS +SLSG +L D + +W Sbjct: 280 -----ESIIFGASSVDFSLSGRLLFAGYNDYTINVW 310 >2AQ5-A nrPDB Length = 402 Score = 41.2 bits (95), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 45/176 (25%), Positives = 68/176 (38%), Gaps = 24/176 (13%) Query: 111 EYGPLLLVASSDGKVSVVEFKENGTTS---PIIIDAHAIGVNSASWAPATIEEDGEHNGT 167 ++ L+ AS G V+ + G P++ H V +W P HN Sbjct: 45 KFMALICEASGGGAFLVLPLGKTGRVDKNVPLVC-GHTAPVLDIAWCP--------HN-- 93 Query: 168 KESRKFVTGGADNLVKIWKYNSDAQTYVLES---TLEGHSDWVRDVAWSPTVLLRSYLAS 224 +G D V +W+ L TLEGH+ V VAW PT ++ L S Sbjct: 94 --DNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTA--QNVLLS 149 Query: 225 VSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTL 280 D ++W D G T L + PD ++ WS G ++ S D +V + Sbjct: 150 AGCDNVILVW--DVGTGAAVLT-LGPDVHPDTIYSVDWSRDGALICTSCRDKRVRV 202 Score = 38.1 bits (87), Expect = 0.004, Method: Compositional matrix adjust. Identities = 31/115 (26%), Positives = 51/115 (44%), Gaps = 8/115 (6%) Query: 24 LATCSSDKTIKIFEVEG-----ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGK 78 +A+ S D T+ ++E+ + + TL GH V V W HP +L S D Sbjct: 97 IASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAW-HPTAQNVLLSAGCDNV 155 Query: 79 VLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKEN 133 +L+W G VH ++ SV W+ G L+ + D +V V+E ++ Sbjct: 156 ILVWDVGTGAAVLTLGPDVHPDTIYSVDWS--RDGALICTSCRDKRVRVIEPRKG 208 >3DWL-C nrPDB Length = 377 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 5/110 (4%) Query: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIW- 82 T ++ ++++E +G K T + H+ V VDWA PK I+ +CS D ++ Sbjct: 26 FVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWA-PKSNRIV-TCSQDRNAYVYE 83 Query: 83 KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKE 132 K +G W Q V + + V+W+P+E V S +SV F++ Sbjct: 84 KRPDGTWKQTLVLLRLNRAATFVRWSPNE--DKFAVGSGARVISVCYFEQ 131 Score = 30.8 bits (68), Expect = 0.80, Method: Compositional matrix adjust. Identities = 48/229 (20%), Positives = 88/229 (38%), Gaps = 37/229 (16%) Query: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 T + + +V +++++ W + H V V WAP ++ S D V Sbjct: 24 TEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSN--RIVTCSQDRNAYV 81 Query: 128 VEFKENGTTSPIIIDAHAIGVNSAS----WAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 E + +GT ++ + +N A+ W+P ED KF G ++ Sbjct: 82 YEKRPDGTWKQTLV---LLRLNRAATFVRWSP---NED----------KFAVGSGARVIS 125 Query: 184 IWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII---WTQDNEQ 240 + + + +V + + + W P +L LA+ DR + + +D + Sbjct: 126 VCYFEQENDWWVSKHLKRPLRSTILSLDWHPNNVL---LAAGCADRKAYVLSAYVRDVDA 182 Query: 241 GP----WKKTLLKE---EKFPDVLW--RASWSLSGNVLALSGGDNKVTL 280 P W L ++P W +S SGN LA +G D+ VT+ Sbjct: 183 KPEASVWGSRLPFNTVCAEYPSGGWVHAVGFSPSGNALAYAGHDSSVTI 231 >5K1B-B nrPDB Length = 677 Score = 40.8 bits (94), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 30/113 (26%), Positives = 52/113 (46%), Gaps = 9/113 (7%) Query: 172 KFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTC 231 + T G D++++IW N Q + S +E H+DWV D+ L S S D T Sbjct: 44 RLFTAGRDSIIRIWSVNQHKQDPYIAS-MEHHTDWVNDIVLCCN---GKTLISASSDTTV 99 Query: 232 IIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 +W + +G TL + + L +++ ++A +G D ++ LW N Sbjct: 100 KVW--NAHKGFCMSTLRTHKDYVKAL---AYAKDKELVASAGLDRQIFLWDVN 147 Score = 32.3 bits (72), Expect = 0.29, Method: Compositional matrix adjust. Identities = 24/77 (31%), Positives = 40/77 (51%), Gaps = 8/77 (10%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHK--LIDTLTGHEGPVWRVDWAHPK 65 H + ++D VL GK L + SSD T+K++ HK + TL H+ V + +A K Sbjct: 74 HTDWVNDIVLCCNGKTLISASSDTTVKVWNA----HKGFCMSTLRTHKDYVKALAYAKDK 129 Query: 66 FGTILASCSYDGKVLIW 82 ++AS D ++ +W Sbjct: 130 --ELVASAGLDRQIFLW 144 >5FA5-B nrPDB Length = 367 Score = 40.8 bits (94), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 49/215 (22%), Positives = 91/215 (42%), Gaps = 39/215 (18%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 H++++ + G + + S D IK++++ + ++ + H V V A P Sbjct: 149 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV--VLSSYRAHAAQVTCVA-ASPHKD 205 Query: 68 TILASCSYDGKVLIWKEENGR-WSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 ++ SCS D ++L+W + SQI A S+ W P + + + +G VS Sbjct: 206 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLP-TSLAWHPQQ-SEVFVFGDENGTVS 263 Query: 127 VVEFKENGTTSPIIIDA-HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 +V+ K +TS ++ A H+ V ++P ++ F+ Sbjct: 264 LVDTK---STSCVLSSAVHSQCVTGLVFSPHSV-------------PFLA---------- 297 Query: 186 KYNSDAQTYVLESTL------EGHSDWVRDVAWSP 214 + D VL+S+L + H D+VRD WSP Sbjct: 298 SLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSP 332 >2P9P-C nrPDB Length = 372 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 29/110 (26%), Positives = 48/110 (43%), Gaps = 4/110 (3%) Query: 23 RLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIW 82 ++A C ++ + I+E G + L H G V VDWA P I+ +C D +W Sbjct: 22 QIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWA-PDSNRIV-TCGTDRNAYVW 79 Query: 83 KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKE 132 + W V + + V+WAP+E V S +S+ F++ Sbjct: 80 TLKGRTWKPTLVILRINRAARCVRWAPNEKK--FAVGSGSRVISICYFEQ 127 Score = 33.9 bits (76), Expect = 0.086, Method: Compositional matrix adjust. Identities = 40/200 (20%), Positives = 76/200 (38%), Gaps = 21/200 (10%) Query: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 T +A C + +V I+++ +W Q+ H+ V V WAP ++ +D V Sbjct: 21 TQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSN--RIVTCGTDRNAYV 78 Query: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 K ++I WAP +KF G ++ I + Sbjct: 79 WTLKGRTWKPTLVILRINRAARCVRWAP-------------NEKKFAVGSGSRVISICYF 125 Query: 188 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT---QDNEQGPWK 244 + +V + + V + W P +L LA+ S D C I++ ++ E+ P Sbjct: 126 EQENDWWVCKHIKKPIRSTVLSLDWHPNSVL---LAAGSCDFKCRIFSAYIKEVEERPAP 182 Query: 245 KTLLKEEKFPDVLWRASWSL 264 + F ++++ +S S Sbjct: 183 TPWGSKMPFGELMFESSSSC 202 >5WLC-LO nrPDB Length = 923 Score = 39.7 bits (91), Expect = 0.001, Method: Compositional matrix adjust. Identities = 28/92 (30%), Positives = 51/92 (55%), Gaps = 6/92 (6%) Query: 41 ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSA 100 +T +L+D L+GHEGPV + ++ ++LAS S+D + IW GR Q+ V+S Sbjct: 461 QTGQLLDALSGHEGPVSCLSFSQE--NSVLASASWDKTIRIW-SIFGRSQQVEPIEVYS- 516 Query: 101 SVNSVQWAPHEYGPLLLVASSDGKVSVVEFKE 132 V ++ P G + V++ G++S+ ++ Sbjct: 517 DVLALSMRPD--GKEVAVSTLKGQISIFNIED 546 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 44/173 (25%), Positives = 73/173 (42%), Gaps = 32/173 (18%) Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV- 125 G+ + + S DGK+ +W +G +A H++SV +VQ+A G ++ +S DG V Sbjct: 357 GSRVVTASEDGKIKVWDITSGFC--LATFEEHTSSVTAVQFAKR--GQVMFSSSLDGTVR 412 Query: 126 --SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL-V 182 ++ ++ T + G + ++ GE G DN + Sbjct: 413 AWDLIRYRNFRTFT---------GTERIQFNCLAVDPSGE--------VVCAGSLDNFDI 455 Query: 183 KIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 +W QT L L GH V +++S S LAS S D+T IW+ Sbjct: 456 HVWS----VQTGQLLDALSGHEGPVSCLSFSQE---NSVLASASWDKTIRIWS 501 Score = 28.5 bits (62), Expect = 3.3, Method: Compositional matrix adjust. Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 4/62 (6%) Query: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 G R+ T S D IK++++ + + T H V V +A K G ++ S S DG V Sbjct: 357 GSRVVTASEDGKIKVWDI--TSGFCLATFEEHTSSVTAVQFA--KRGQVMFSSSLDGTVR 412 Query: 81 IW 82 W Sbjct: 413 AW 414 >5I2T-A nrPDB Length = 742 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 28/92 (30%), Positives = 51/92 (55%), Gaps = 6/92 (6%) Query: 41 ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSA 100 +T +L+D L+GHEGPV + ++ ++LAS S+D + IW GR Q+ V+S Sbjct: 486 QTGQLLDALSGHEGPVSCLSFSQE--NSVLASASWDKTIRIW-SIFGRSQQVEPIEVYS- 541 Query: 101 SVNSVQWAPHEYGPLLLVASSDGKVSVVEFKE 132 V ++ P G + V++ G++S+ ++ Sbjct: 542 DVLALSMRPD--GKEVAVSTLKGQISIFNIED 571 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 44/173 (25%), Positives = 73/173 (42%), Gaps = 32/173 (18%) Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV- 125 G+ + + S DGK+ +W +G +A H++SV +VQ+A G ++ +S DG V Sbjct: 382 GSRVVTASEDGKIKVWDITSGFC--LATFEEHTSSVTAVQFAKR--GQVMFSSSLDGTVR 437 Query: 126 --SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL-V 182 ++ ++ T + G + ++ GE G DN + Sbjct: 438 AWDLIRYRNFRTFT---------GTERIQFNCLAVDPSGE--------VVCAGSLDNFDI 480 Query: 183 KIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 +W QT L L GH V +++S S LAS S D+T IW+ Sbjct: 481 HVWS----VQTGQLLDALSGHEGPVSCLSFSQE---NSVLASASWDKTIRIWS 526 Score = 28.5 bits (62), Expect = 3.5, Method: Compositional matrix adjust. Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 4/62 (6%) Query: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 G R+ T S D IK++++ + + T H V V +A K G ++ S S DG V Sbjct: 382 GSRVVTASEDGKIKVWDI--TSGFCLATFEEHTSSVTAVQFA--KRGQVMFSSSLDGTVR 437 Query: 81 IW 82 W Sbjct: 438 AW 439 >5NZU-C nrPDB Length = 905 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 54/212 (25%), Positives = 89/212 (41%), Gaps = 28/212 (13%) Query: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 + T + D I++F T + + H + R HP IL S S D + +W Sbjct: 72 VVTGADDMQIRVFNYN--TLERVHMFEAHSDYI-RCIAVHPTQPFILTS-SDDMLIKLW- 126 Query: 84 EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSP-IIID 142 + + +WS V H+ V + P + AS D + V + G++SP ++ Sbjct: 127 DWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFA-SASLDRTIKVWQL---GSSSPNFTLE 182 Query: 143 AHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEG 202 H GVN + ++G + ++G D LVKIW Y Q TLEG Sbjct: 183 GHEKGVNCIDY----------YSGGDKPY-LISGADDRLVKIWDY----QNKTCVQTLEG 227 Query: 203 HSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 H+ V ++ P + + + + S+D T IW Sbjct: 228 HAQNVSCASFHPELPI---IITGSEDGTVRIW 256 Score = 32.0 bits (71), Expect = 0.33, Method: Compositional matrix adjust. Identities = 20/72 (27%), Positives = 35/72 (48%), Gaps = 5/72 (6%) Query: 168 KESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQ 227 K++ +F + D +K+W+ S + + TLEGH V + + + + YL S + Sbjct: 153 KDNNQFASASLDRTIKVWQLGSSSPNF----TLEGHEKGVNCIDYY-SGGDKPYLISGAD 207 Query: 228 DRTCIIWTQDNE 239 DR IW N+ Sbjct: 208 DRLVKIWDYQNK 219 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 16/54 (29%), Positives = 28/54 (51%), Gaps = 3/54 (5%) Query: 78 KVLIWKEENGRWSQIAVHAVHSASVNSVQWAPH---EYGPLLLVASSDGKVSVV 128 ++ + E +W Q+A A+ + Q H +YG LLL+A++ G S+V Sbjct: 659 QLAVEAESEQKWKQLAELAISKCQFSLAQECLHHAQDYGGLLLLATASGNASMV 712 >4BTS-AR nrPDB Length = 343 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 55/223 (24%), Positives = 90/223 (40%), Gaps = 33/223 (14%) Query: 69 ILASCSYDGKVLIWK---EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 +L S S D V+IWK EE + I A+ + A + + +S D + Sbjct: 41 VLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSSWDKTL 100 Query: 126 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 + + + GTT + H V S +++P ++R+ ++ GA+ +K+W Sbjct: 101 RLWDLR-TGTTYKRFV-GHQSEVYSVAFSP-------------DNRQILSAGAEREIKLW 145 Query: 186 KYNSDAQTYVLESTLEGHSDWVRDVAWSPTVL-------LRSYLASVSQDRTCIIWTQDN 238 + + E E HSDWV V +SP + Y ASV D +W N Sbjct: 146 NILGECKFSSAEK--ENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVW---N 200 Query: 239 EQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 + T E + L S S +G +A G D K+ +W Sbjct: 201 TNFQIRYTFKAHESNVNHL---SISPNGKYIATGGKDKKLLIW 240 Score = 31.6 bits (70), Expect = 0.43, Method: Compositional matrix adjust. Identities = 46/195 (23%), Positives = 70/195 (35%), Gaps = 44/195 (22%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE-GETHKLIDTLTGHEGPVWRVDWA--- 62 HN + D L + S DKT++++++ G T+K GH+ V+ V ++ Sbjct: 74 GHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYK---RFVGHQSEVYSVAFSPDN 130 Query: 63 ----------HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEY 112 K IL C + KE + W ++ S N VQ + Sbjct: 131 RQILSAGAEREIKLWNILGECKFSSAE---KENHSDWVSCVRYSPIMKSANKVQ----PF 183 Query: 113 GPLLLVASSDGKVSV--VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKES 170 P DG++ V F+ T AH VN S +P NG Sbjct: 184 APYFASVGWDGRLKVWNTNFQIRYT-----FKAHESNVNHLSISP---------NG---- 225 Query: 171 RKFVTGGADNLVKIW 185 + TGG D + IW Sbjct: 226 KYIATGGKDKKLLIW 240 >3JAP-g nrPDB Length = 326 Score = 38.5 bits (88), Expect = 0.003, Method: Compositional matrix adjust. Identities = 63/251 (25%), Positives = 104/251 (41%), Gaps = 26/251 (10%) Query: 24 LATCSSDKTI---KIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 L + S DKT+ ++ E E + + + GH V D G S S+D + Sbjct: 34 LVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQ--DVVVSADGNYAVSASWDKTLR 91 Query: 81 IWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII 140 +W G + A H+ V SV A ++ AS D + V + G + ++ Sbjct: 92 LWNLATG--NSEARFVGHTGDVLSV--AIDANSSKIISASRDKTIRV--WNTVGDCAYVL 145 Query: 141 IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTL 200 + H V AP +E DGE + + + FV+ G D +V+ W N D +Y +E+ Sbjct: 146 L-GHTDWVTKVRVAPKNLE-DGEVDDGRIT--FVSAGMDKIVRSWSLNED--SYRIEADF 199 Query: 201 EGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKF-----PD 255 GH++++ V SP S AS +D +W + + K+E F P Sbjct: 200 IGHNNYINVVQPSPD---GSLAASAGKDGQIYVWNL-KHKSAFMNFDAKDEVFALAFSPS 255 Query: 256 VLWRASWSLSG 266 W + + SG Sbjct: 256 RFWLTAATASG 266 Score = 30.8 bits (68), Expect = 0.70, Method: Compositional matrix adjust. Identities = 20/47 (42%), Positives = 27/47 (57%), Gaps = 3/47 (6%) Query: 195 VLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT-QDNEQ 240 VL TLEGH+ WV + S + + L S S+D+T I W +NEQ Sbjct: 9 VLRGTLEGHNGWVTSL--STSAAQPNLLVSGSRDKTLISWRLTENEQ 53 >3ODT-A nrPDB Length = 313 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 31/90 (34%), Positives = 47/90 (52%), Gaps = 8/90 (8%) Query: 4 IANAHNELI-HDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 + HN+++ H AV+D +CS+D IK+ V+ T ++ T GHE V+ + Sbjct: 179 FSGIHNDVVRHLAVVD--DGHFISCSNDGLIKL--VDMHTGDVLRTYEGHESFVYCIKLL 234 Query: 63 HPKFGTILASCSYDGKVLIWKEENGRWSQI 92 P G I+ SC D V IW +ENG Q+ Sbjct: 235 -PN-GDIV-SCGEDRTVRIWSKENGSLKQV 261 Score = 36.2 bits (82), Expect = 0.016, Method: Compositional matrix adjust. Identities = 50/190 (26%), Positives = 82/190 (43%), Gaps = 36/190 (18%) Query: 1 MVVIANAHNELIHDA-VLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWR- 58 +V AHN + DA V+ + + T S+DKTIK++ + K+I T +G V R Sbjct: 134 LVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLW----QNDKVIKTFSGIHNDVVRH 189 Query: 59 ---VDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPL 115 VD H SCS DG + + G + + H + V ++ P+ Sbjct: 190 LAVVDDGH------FISCSNDGLIKLVDMHTG--DVLRTYEGHESFVYCIKLLPNGD--- 238 Query: 116 LLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVT 175 +V+ + + + KENG+ +I AI + W+ D NG + Sbjct: 239 -IVSCGEDRTVRIWSKENGSLKQVIT-LPAISI----WSV-----DCMSNG-----DIIV 282 Query: 176 GGADNLVKIW 185 G +DNLV+I+ Sbjct: 283 GSSDNLVRIF 292 >1NR0-A nrPDB Length = 611 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 29/118 (24%), Positives = 52/118 (44%), Gaps = 11/118 (9%) Query: 168 KESRKF--VTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASV 225 K SR F ++G DN V I+ + + +ST H+ +V V ++P S AS Sbjct: 156 KPSRPFRIISGSDDNTVAIF----EGPPFKFKSTFGEHTKFVHSVRYNPD---GSLFAST 208 Query: 226 SQDRTCIIW--TQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 D T +++ + G ++ LK ++ +WS G +A + D + +W Sbjct: 209 GGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIW 266 Score = 30.8 bits (68), Expect = 0.84, Method: Compositional matrix adjust. Identities = 51/213 (23%), Positives = 84/213 (39%), Gaps = 40/213 (18%) Query: 33 IKIFEVEGETHKLIDTLTGHEGPVWRVDW--AHPKFGTILASCSYDGKVLIWK--EENGR 88 ++I++ TH L T+ GPV + W + + G V ++ NG Sbjct: 83 VRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGN 142 Query: 89 WSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS-DGKVSVVE---FKENGTTSPIIIDAH 144 + + ++NSV + P P +++ S D V++ E FK T H Sbjct: 143 LTG------QARAMNSVDFKPSR--PFRIISGSDDNTVAIFEGPPFKFKST-----FGEH 189 Query: 145 AIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLE-STLE-- 201 V+S + P DG F + G D + ++ +T V E +L+ Sbjct: 190 TKFVHSVRYNP-----DGS--------LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV 236 Query: 202 GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 HS V + WSP + +AS S D+T IW Sbjct: 237 AHSGSVFGLTWSPD---GTKIASASADKTIKIW 266 >4GGA-A nrPDB Length = 420 Score = 37.4 bits (85), Expect = 0.007, Method: Compositional matrix adjust. Identities = 40/152 (26%), Positives = 59/152 (38%), Gaps = 24/152 (15%) Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 K G LA + +V +W + + ++ HSA V S+ W + +L S G Sbjct: 157 KEGNYLAVGTSSAEVQLWDVQQQK--RLRNMTSHSARVGSLSWNSY----ILSSGSRSGH 210 Query: 125 VSV--VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLV 182 + V E+ + + H+ V WAP DG H +GG DNLV Sbjct: 211 IHHHDVRVAEHHVAT---LSGHSQEVCGLRWAP-----DGRH--------LASGGNDNLV 254 Query: 183 KIWKYNSDAQTYVLESTLEGHSDWVRDVAWSP 214 +W +V T H V+ VAW P Sbjct: 255 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 286 >5G04-R nrPDB Length = 499 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 40/152 (26%), Positives = 59/152 (38%), Gaps = 24/152 (15%) Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 K G LA + +V +W + + ++ HSA V S+ W + +L S G Sbjct: 236 KEGNYLAVGTSSAEVQLWDVQQQK--RLRNMTSHSARVGSLSWNSY----ILSSGSRSGH 289 Query: 125 VSV--VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLV 182 + V E+ + + H+ V WAP DG H +GG DNLV Sbjct: 290 IHHHDVRVAEHHVAT---LSGHSQEVCGLRWAP-----DGRH--------LASGGNDNLV 333 Query: 183 KIWKYNSDAQTYVLESTLEGHSDWVRDVAWSP 214 +W +V T H V+ VAW P Sbjct: 334 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 365 >5LCW-Q nrPDB Length = 374 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 40/152 (26%), Positives = 59/152 (38%), Gaps = 24/152 (15%) Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 K G LA + +V +W + + ++ HSA V S+ W + +L S G Sbjct: 111 KEGNYLAVGTSSAEVQLWDVQQQK--RLRNMTSHSARVGSLSWNSY----ILSSGSRSGH 164 Query: 125 VSV--VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLV 182 + V E+ + + H+ V WAP DG H +GG DNLV Sbjct: 165 IHHHDVRVAEHHVAT---LSGHSQEVCGLRWAP-----DGRH--------LASGGNDNLV 208 Query: 183 KIWKYNSDAQTYVLESTLEGHSDWVRDVAWSP 214 +W +V T H V+ VAW P Sbjct: 209 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 240 >4V8M-A7 nrPDB Length = 318 Score = 37.0 bits (84), Expect = 0.010, Method: Compositional matrix adjust. Identities = 45/176 (25%), Positives = 74/176 (42%), Gaps = 28/176 (15%) Query: 49 LTGHEGPVWRVDWAH-PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAV-------HSA 100 LTGH G V + P+ T + S S D +L W R S + + HSA Sbjct: 9 LTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSA 68 Query: 101 SVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEE 160 V+ V A G + AS D + + +NG + H V S +++P Sbjct: 69 FVSDV--ALSNNGNFAVSASWDHSLRLWNL-QNGQCQYKFL-GHTKDVLSVAFSP----- 119 Query: 161 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV 216 ++R+ V+GG DN +++W + + + H+DWV V +SP++ Sbjct: 120 --------DNRQIVSGGRDNALRVWNVKGECMHTL---SRGAHTDWVSCVRFSPSL 164 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 49/186 (26%), Positives = 77/186 (41%), Gaps = 25/186 (13%) Query: 49 LTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWA 108 L GH V D A G S S+D + +W +NG+ + H+ V SV ++ Sbjct: 63 LEGHSAFV--SDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLG--HTKDVLSVAFS 118 Query: 109 PHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTK 168 P ++ D + V K + AH V+ ++P+ Sbjct: 119 PDNR--QIVSGGRDNALRVWNVKGE-CMHTLSRGAHTDWVSCVRFSPSL----------- 164 Query: 169 ESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQD 228 ++ V+GG DNLVK+W D T L + L+GH+++V V SP S AS +D Sbjct: 165 DAPVIVSGGWDNLVKVW----DLATGRLVTDLKGHTNYVTSVTVSPD---GSLCASSDKD 217 Query: 229 RTCIIW 234 +W Sbjct: 218 GVARLW 223 >4AEZ-A nrPDB Length = 401 Score = 37.0 bits (84), Expect = 0.010, Method: Compositional matrix adjust. Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 24/174 (13%) Query: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASC--SYDGK 78 G +LA+ +D ++I++ K T T H V V W P +LA+ + D + Sbjct: 229 GLQLASGGNDNVVQIWDARSSIPKF--TKTNHNAAVKAVAWC-PWQSNLLATGGGTMDKQ 285 Query: 79 VLIWKEENGRWSQIAVHAVHSAS-VNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTS 137 + W G V+ V + S V S+ W+PH + D +S+ + +G T Sbjct: 286 IHFWNAATG----ARVNTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTK 341 Query: 138 PIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK-YNSD 190 + I AH V ++ +P + R T +D +K W+ Y+ D Sbjct: 342 QVDIPAHDTRVLYSALSP-------------DGRILSTAASDENLKFWRVYDGD 382 Score = 32.7 bits (73), Expect = 0.20, Method: Compositional matrix adjust. Identities = 16/43 (37%), Positives = 26/43 (60%), Gaps = 4/43 (9%) Query: 172 KFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSP 214 + +GG DN+V+IW DA++ + + T H+ V+ VAW P Sbjct: 231 QLASGGNDNVVQIW----DARSSIPKFTKTNHNAAVKAVAWCP 269 Score = 32.3 bits (72), Expect = 0.24, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 83/207 (40%), Gaps = 32/207 (15%) Query: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHE----GPVWRVDWAHPKFGTILASCSYDGKV 79 L++ S I +V H+ I TL GH G WR D G LAS D V Sbjct: 189 LSSGSRSGAIHHHDVRIANHQ-IGTLQGHSSEVCGLAWRSD------GLQLASGGNDNVV 241 Query: 80 LIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV-SVVEFKENGTTSP 138 IW + + H+A+V +V W P + L+A+ G + + F T + Sbjct: 242 QIWDARSSIPKFTKTN--HNAAVKAVAWCPWQSN---LLATGGGTMDKQIHFWNAATGAR 296 Query: 139 I-IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLE 197 + +DA + V S W+P + E H G DN + IW Y+S T ++ Sbjct: 297 VNTVDAGS-QVTSLIWSPHSKEIMSTH-----------GFPDNNLSIWSYSSSGLTKQVD 344 Query: 198 STLEGHSDWVRDVAWSPTVLLRSYLAS 224 + H V A SP + S AS Sbjct: 345 --IPAHDTRVLYSALSPDGRILSTAAS 369 >6CHG-A nrPDB Length = 312 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 50/192 (26%), Positives = 80/192 (41%), Gaps = 25/192 (13%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 M+ + H E I+ K +A+ S D T++I + + I L GH PV + Sbjct: 46 MMKLTTTHKECINCLCWSPDSKCIASGSEDFTVEITHI---IYGRIRRLMGHTAPVISIC 102 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 + + G IL S S D + W +G + + + HS +V S+ P +L S Sbjct: 103 YNNK--GNILCSSSMDESIKEWHVLSG--TALKTMSAHSDAVVSID-IPKFDSSILSSGS 157 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDG--EHNGTKESR--KFV-T 175 DG + + + + + D W I EDG + K SR KF+ Sbjct: 158 YDGLIRIFDTESGHCLKTLTYDK--------DW----IAEDGVVPISTVKFSRNGKFLLV 205 Query: 176 GGADNLVKIWKY 187 DN+VK+W+Y Sbjct: 206 KSLDNVVKLWEY 217 >4N14-A nrPDB Length = 314 Score = 37.0 bits (84), Expect = 0.012, Method: Compositional matrix adjust. Identities = 40/152 (26%), Positives = 59/152 (38%), Gaps = 24/152 (15%) Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 K G LA + +V +W + + ++ HSA V S+ W + +L S G Sbjct: 73 KEGNYLAVGTSSAEVQLWDVQQQK--RLRNMTSHSARVGSLSWNSY----ILSSGSRSGH 126 Query: 125 VSV--VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLV 182 + V E+ + + H+ V WAP DG H +GG DNLV Sbjct: 127 IHHHDVRVAEHHVAT---LSGHSQEVCGLRWAP-----DGRH--------LASGGNDNLV 170 Query: 183 KIWKYNSDAQTYVLESTLEGHSDWVRDVAWSP 214 +W +V T H V+ VAW P Sbjct: 171 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 202 >4A11-B nrPDB Length = 408 Score = 35.4 bits (80), Expect = 0.029, Method: Compositional matrix adjust. Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 8/121 (6%) Query: 78 KVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTS 137 KV + ++G S I H + +V W+P Y +L AS+D +V + + + + Sbjct: 167 KVQLCDLKSGSCSHIL--QGHRQEILAVSWSP-RYDYILATASADSRVKLWDVRR-ASGC 222 Query: 138 PIIIDAHAIGVNSASWAPATIEEDGEHNG---TKESRKFVTGGADNLVKIWKYNSDAQTY 194 I +D H G S + A +G+ NG T + +T G DN +++W ++ T Sbjct: 223 LITLDQHN-GKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTL 281 Query: 195 V 195 V Sbjct: 282 V 282 Score = 30.0 bits (66), Expect = 1.2, Method: Compositional matrix adjust. Identities = 60/263 (22%), Positives = 99/263 (37%), Gaps = 43/263 (16%) Query: 41 ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENG-RWSQIAVHAV-- 97 E +K D H G + +D P G + S DG ++++ EN R S AV Sbjct: 31 ELNKDRDVERIHGGGINTLD-IEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCS 89 Query: 98 --------HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVN 149 H SV +VQW PH+ G + +S D + V + N + + + V Sbjct: 90 IGRDHPDVHRYSVETVQWYPHDTG-MFTSSSFDKTLKV--WDTNTLQTADVFNFEET-VY 145 Query: 150 SASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRD 209 S +P + + GT+ + V++ S + +++ L+GH + Sbjct: 146 SHHMSPVSTKHCLVAVGTRGPK----------VQLCDLKSGSCSHI----LQGHRQEILA 191 Query: 210 VAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVL 269 V+WSP LA+ S D +W G K + A+ + +G V Sbjct: 192 VSWSPR--YDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVN 249 Query: 270 ALS-----------GGDNKVTLW 281 L G DN++ LW Sbjct: 250 GLCFTSDGLHLLTVGTDNRMRLW 272 >6BX3-A nrPDB Length = 314 Score = 35.0 bits (79), Expect = 0.036, Method: Compositional matrix adjust. Identities = 59/238 (24%), Positives = 95/238 (39%), Gaps = 29/238 (12%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H + + G L T S D++IKI++ + L+ T++ H V VD Sbjct: 93 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS--LMKTISAHSEAVVSVDVPMND- 149 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSV----QWAPHEYGPLLLVASSD 122 +IL+S SYDG + I+ E G + + N V Q E LLV S D Sbjct: 150 SSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLD 209 Query: 123 GKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIE-EDGEHNGTKESRKFVTGGADNL 181 G V + + + GV S + EDG S V G +N Sbjct: 210 GVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDG-------STPLVISGYEN- 261 Query: 182 VKIWKYNSDAQTY--VLESTLEGHSDWVRDVAWSPTVLLRSY---LASVSQDRTCIIW 234 I+ +NSD ++ +L+ +L HS SP + + + + S++ + C +W Sbjct: 262 GDIYCWNSDTKSLLQLLDGSLYHHS--------SPVMSIHCFGNIMCSLALNGDCCLW 311 >6F1U-h nrPDB Length = 612 Score = 35.0 bits (79), Expect = 0.042, Method: Compositional matrix adjust. Identities = 55/237 (23%), Positives = 94/237 (39%), Gaps = 24/237 (10%) Query: 51 GHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSAS----VNSVQ 106 H PV+ V+ + L S S DGK+ W + Q ++ VH S V S+ Sbjct: 353 AHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMS 412 Query: 107 WAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI--IIDAHAIGVNSASWAPATIEEDGEH 164 + + +V S +G SV +G+ + I + + H + A D H Sbjct: 413 FPVGDVNN-FVVGSEEG--SVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSH 469 Query: 165 NGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLAS 224 FVT D VK+W ++ Y + E ++ +V DV WSPT + A Sbjct: 470 -------LFVTSSFDWTVKLWSTKNNKPLY----SFEDNAGYVYDVMWSPT--HPALFAC 516 Query: 225 VSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 V +W +N+ ++ E L R W+ SG +A+ + ++ ++ Sbjct: 517 VDGMGRLDLWNLNNDTEVPTASISVEGN--PALNRVRWTHSGREIAVGDSEGQIVIY 571 >5Z56-q nrPDB Length = 504 Score = 34.7 bits (78), Expect = 0.048, Method: Compositional matrix adjust. Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 11/96 (11%) Query: 143 AHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEG 202 A +G++SAS P + D ++ K +TGGAD V ++ +S+ + +TL+G Sbjct: 211 ASHVGLHSASI-PGILALD---LCPSDTNKILTGGADKNVVVFDKSSEQ----ILATLKG 262 Query: 203 HSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDN 238 H+ V V + P+ + + S S D T IW+ N Sbjct: 263 HTKKVTSVVFHPS---QDLVFSASPDATIRIWSVPN 295 >5UZ7-B nrPDB Length = 351 Score = 34.7 bits (78), Expect = 0.048, Method: Compositional matrix adjust. Identities = 52/225 (23%), Positives = 84/225 (37%), Gaps = 47/225 (20%) Query: 48 TLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAV--HSASVNSV 105 TL GH ++ + W +L S S DGK++IW ++ VHA+ S+ V + Sbjct: 61 TLRGHLAKIYAMHWGTDS--RLLVSASQDGKLIIWDS----YTTNKVHAIPLRSSWVMTC 114 Query: 106 QWAPHEYGPLLLVASSDGKVSVVEFKEN-----------GTTSPI----IIDAHAIGVNS 150 +AP G + D S+ K G T + +D + I +S Sbjct: 115 AYAPS--GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSS 172 Query: 151 ASWAPAT--IE------EDGEHNG-------TKESRKFVTGGADNLVKIWKYNSDAQTYV 195 A IE H G ++R FV+G D K+W D + + Sbjct: 173 GDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW----DVREGM 228 Query: 196 LESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 T GH + + + P + A+ S D TC ++ +Q Sbjct: 229 CRQTFTGHESDINAICFFPN---GNAFATGSDDATCRLFDLRADQ 270 >5K19-A nrPDB Length = 569 Score = 34.7 bits (78), Expect = 0.054, Method: Compositional matrix adjust. Identities = 33/121 (27%), Positives = 51/121 (42%), Gaps = 27/121 (22%) Query: 97 VHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKE---NGTTSPIIIDAHAIGVNSASW 153 V ++N ++P G L S DG + V F +GT + ++ G+ W Sbjct: 218 VGEGALNEFAFSPD--GKFLACVSQDGFLRVFNFDSVELHGT-----MKSYFGGLLCVCW 270 Query: 154 APATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWS 213 +P DG++ VTGG D+LV +W + D + GH WV VA+ Sbjct: 271 SP-----DGKY--------IVTGGEDDLVTVWSF-VDCRVIARG---HGHKSWVSVVAFD 313 Query: 214 P 214 P Sbjct: 314 P 314 >1PI6-A nrPDB Length = 615 Score = 34.7 bits (78), Expect = 0.054, Method: Compositional matrix adjust. Identities = 39/179 (21%), Positives = 74/179 (41%), Gaps = 23/179 (12%) Query: 12 IHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILA 71 I D D+ G+RL + + ++ + ++GH R++ H K + Sbjct: 119 ISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHS---QRINACHLKQSRPMR 175 Query: 72 SCSY--DGKVLIWKEENGRWSQI-AVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 S + DG V+ ++ ++S H + V V+++P + G ++ SD K+S Sbjct: 176 SMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSP-DSGEFVITVGSDRKISCF 234 Query: 129 EFKENGTTSPIIIDAHAI--GVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 + K I D + G+ + SW +S+KF T GAD +++W Sbjct: 235 DGKSGEFLKYIEDDQEPVQGGIFALSWL--------------DSQKFATVGADATIRVW 279 Score = 27.7 bits (60), Expect = 6.3, Method: Compositional matrix adjust. Identities = 30/128 (23%), Positives = 58/128 (45%), Gaps = 37/128 (28%) Query: 23 RLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIW 82 R+ + S D T+ +E+ + +++ T++GH + + +P L S SYDG+++ Sbjct: 311 RIISLSLDGTLNFYELGHD--EVLKTISGHNKGITALT-VNP-----LISGSYDGRIM-- 360 Query: 83 KEENGRWSQIAVHAVHSASV-----------NSVQW---------APHEYG--PLLLVAS 120 WS ++H HS + +S+ W HE+G P + A+ Sbjct: 361 -----EWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASAN 415 Query: 121 SDGKVSVV 128 +DG +V+ Sbjct: 416 NDGFTAVL 423 >4V7E-Bg nrPDB Length = 380 Score = 34.3 bits (77), Expect = 0.059, Method: Compositional matrix adjust. Identities = 45/195 (23%), Positives = 74/195 (37%), Gaps = 30/195 (15%) Query: 48 TLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAV--HSASVNSV 105 TL GH G V+ +DW K + S S DG++++W N SQ HA+ H V Sbjct: 61 TLQGHSGKVYSLDWTPEK--NWIVSASQDGRLIVW---NALTSQ-KTHAIKLHCPWVMEC 114 Query: 106 QWAPHEYGPLLLVASSDGKVSVVEFKENGT---TSPI--IIDAHAIGVNSASWAPATIEE 160 +AP+ G + D S+ P+ ++ H +S + P Sbjct: 115 AFAPN--GQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVP----- 167 Query: 161 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTL-EGHSDWVRDVAWSPTVLLR 219 + + +TG D +W + + + S GH+ V ++ S L Sbjct: 168 -------DQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADV--LSLSINSLNA 218 Query: 220 SYLASVSQDRTCIIW 234 + S S D T +W Sbjct: 219 NMFISGSCDTTVRLW 233 >5XYI-g nrPDB Length = 335 Score = 34.3 bits (77), Expect = 0.073, Method: Compositional matrix adjust. Identities = 54/218 (24%), Positives = 84/218 (38%), Gaps = 44/218 (20%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 HN + D L L T S D T++++++ T K + GH+ V V ++ Sbjct: 79 HNHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKL--FLGHKKDVLGVTFSPCNRR 136 Query: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPH--EYGPLLL-VASSDGK 124 I S D +V IW +++ S+ V SV AP E PL++ V DGK Sbjct: 137 II--SVGRDNQVKIWNILGENKAELQC----SSWVTSVACAPMADETSPLVIAVGCWDGK 190 Query: 125 VSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKF-------VTGG 177 V + ++ I+E H+G S F +TGG Sbjct: 191 VYIWSIEKEAK---------------------LIKEFKAHDGRCTSVDFTPDGKWVITGG 229 Query: 178 ADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPT 215 +D V +W + A+T + H+ VA PT Sbjct: 230 SDRKVVMWLTENGAKTISFTAPSPVHA-----VAACPT 262 >5OPT-p nrPDB Length = 318 Score = 33.9 bits (76), Expect = 0.084, Method: Compositional matrix adjust. Identities = 23/66 (34%), Positives = 35/66 (53%), Gaps = 7/66 (10%) Query: 169 ESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQD 228 E+ V+GG DNLVK+W D + L + L+GH++++ V SP S AS +D Sbjct: 165 ETPLIVSGGWDNLVKVW----DIASGRLLTDLKGHTNYITSVTVSPD---GSLCASSDKD 217 Query: 229 RTCIIW 234 +W Sbjct: 218 GVARLW 223 Score = 28.9 bits (63), Expect = 2.9, Method: Compositional matrix adjust. Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 15/122 (12%) Query: 172 KFVTGGADNLVKIWKYNSD-----AQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVS 226 K V+ DN + W N D + E LEGHS +V DVA S + S S Sbjct: 30 KAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALSNN---GDFAVSAS 86 Query: 227 QDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLE 286 D + +W + G + L K DVL ++S + G DN + +W N++ Sbjct: 87 WDHSLRLWNL--QTGVCQHKFLGHTK--DVL-SVTFSPDNRQIVSGGRDNALRVW--NVK 139 Query: 287 GK 288 G+ Sbjct: 140 GE 141 >4LG8-A nrPDB Length = 354 Score = 33.9 bits (76), Expect = 0.084, Method: Compositional matrix adjust. Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 11/96 (11%) Query: 143 AHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEG 202 A +G++SAS P + D ++ K +TGGAD V ++ +S+ + +TL+G Sbjct: 61 ASHVGLHSAS-IPGILALD---LCPSDTNKILTGGADKNVVVFDKSSEQ----ILATLKG 112 Query: 203 HSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDN 238 H+ V V + P+ + + S S D T IW+ N Sbjct: 113 HTKKVTSVVFHPS---QDLVFSASPDATIRIWSVPN 145 >3MKQ-A nrPDB Length = 814 Score = 33.9 bits (76), Expect = 0.092, Method: Compositional matrix adjust. Identities = 18/65 (27%), Positives = 32/65 (49%), Gaps = 7/65 (10%) Query: 174 VTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII 233 + G D ++++ YN+ + E H D++R +A PT + Y+ S S D T + Sbjct: 71 IVGSDDFRIRVFNYNTGEKVV----DFEAHPDYIRSIAVHPT---KPYVLSGSDDLTVKL 123 Query: 234 WTQDN 238 W +N Sbjct: 124 WNWEN 128 Score = 32.0 bits (71), Expect = 0.38, Method: Compositional matrix adjust. Identities = 35/114 (30%), Positives = 49/114 (42%), Gaps = 23/114 (20%) Query: 173 FVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 232 +T D +KIW Y QT +TLEGH V + PT+ + + S S+D T Sbjct: 201 MITASDDLTIKIWDY----QTKSCVATLEGHMSNVSFAVFHPTLPI---IISGSEDGTLK 253 Query: 233 IWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLS------GNVLALSGGDNKVTL 280 IW + K EK +V SW ++ N +A SG DN T+ Sbjct: 254 IWNS---------STYKVEKTLNVGLERSWCIATHPTGRKNYIA-SGFDNGFTV 297 >5OQL-d nrPDB Length = 446 Score = 33.5 bits (75), Expect = 0.10, Method: Compositional matrix adjust. Identities = 61/279 (21%), Positives = 104/279 (37%), Gaps = 31/279 (11%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 AHN ++ K+L +C++D IK+++ T EG + H Sbjct: 108 AHNNIVKGLTFTN-DKKLLSCATD-GIKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSA 165 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 T AS S G + IW E+ Q ++ V + E + VA+ D + Sbjct: 166 NTFAAS-SGQGCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVAT-DRSII 223 Query: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 + + + N P+I N + P E+ D+ + I+ Sbjct: 224 LFDLRTN---MPVIKTVLHFACNRIVFNPM------------EAMNLAVASEDHNIYIF- 267 Query: 187 YNSDAQTYVLESTLE-GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKK 245 DA+ + ++ GH V DV +SPT L S S DRT +W +D + Sbjct: 268 ---DARNFDKALNIQKGHVAAVMDVEFSPTG---EELVSGSYDRTIRLWRRD---AGHSR 318 Query: 246 TLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 + ++ V +R W++ + D V LW+ N Sbjct: 319 DVYHTKRMQRV-FRTMWTMDSKYILTGSDDGNVRLWRAN 356 >6ID0-T nrPDB Length = 514 Score = 33.5 bits (75), Expect = 0.11, Method: Compositional matrix adjust. Identities = 25/63 (39%), Positives = 31/63 (49%), Gaps = 9/63 (14%) Query: 173 FVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRS-YLASVSQDRTC 231 FVTG AD +KIW D + L+ +L GH VR V V RS YL S +D+ Sbjct: 219 FVTGSADRTIKIW----DLASGKLKLSLTGHISTVRGV----IVSTRSPYLFSCGEDKQV 270 Query: 232 IIW 234 W Sbjct: 271 KCW 273 Score = 31.6 bits (70), Expect = 0.49, Method: Compositional matrix adjust. Identities = 27/91 (29%), Positives = 41/91 (45%), Gaps = 10/91 (10%) Query: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVW--RVDWAHPKFGTILASCSYDGKVLI 81 L TCS D T +I++V T + TL+GH V R A P+ + + S+D + + Sbjct: 303 LVTCSRDSTARIWDV--RTKASVHTLSGHTNAVATVRCQAAEPQ----IITGSHDTTIRL 356 Query: 82 WKEENGRWSQIAVHAVHSASVNSVQWAPHEY 112 W G+ + H SV +V P Y Sbjct: 357 WDLVAGKTRVTLTN--HKKSVRAVVLHPRHY 385 >2PM9-A nrPDB Length = 416 Score = 33.5 bits (75), Expect = 0.12, Method: Compositional matrix adjust. Identities = 29/108 (26%), Positives = 48/108 (44%), Gaps = 7/108 (6%) Query: 23 RLATCS---SDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKV 79 R+AT + +D +I I+++ L GH+ + +DW H + +L S D V Sbjct: 229 RVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCH-QDEHLLLSSGRDNTV 287 Query: 80 LIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 L+W E+ Q++ ++AP E L AS D K+ V Sbjct: 288 LLWNPESAE--QLSQFPARGNWCFKTKFAP-EAPDLFACASFDNKIEV 332 >2YNP-A nrPDB Length = 604 Score = 33.5 bits (75), Expect = 0.12, Method: Compositional matrix adjust. Identities = 18/65 (27%), Positives = 32/65 (49%), Gaps = 7/65 (10%) Query: 174 VTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII 233 + G D ++++ YN+ + E H D++R +A PT + Y+ S S D T + Sbjct: 71 IVGSDDFRIRVFNYNTGEKVV----DFEAHPDYIRSIAVHPT---KPYVLSGSDDLTVKL 123 Query: 234 WTQDN 238 W +N Sbjct: 124 WNWEN 128 Score = 32.0 bits (71), Expect = 0.30, Method: Compositional matrix adjust. Identities = 67/260 (25%), Positives = 97/260 (37%), Gaps = 43/260 (16%) Query: 28 SSDKTIKIFEVE-GETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEEN 86 S D I++F GE K++D H + R HP +L S S D V +W EN Sbjct: 74 SDDFRIRVFNYNTGE--KVVD-FEAHPDYI-RSIAVHPTKPYVL-SGSDDLTVKLWNWEN 128 Query: 87 GRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAI 146 W+ H V V + P + P + + V T + + Sbjct: 129 -NWALEQTFEGHEHFVMCVAFNPKD--PSTFASGCLDRTVKVWSLGQSTPNFTLTTGQER 185 Query: 147 GVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDW 206 GVN + P + +T D +KIW Y QT +TLEGH Sbjct: 186 GVNYVDYYPL-----------PDKPYMITASDDLTIKIWDY----QTKSCVATLEGHMSN 230 Query: 207 VRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLS- 265 V + PT+ + + S S+D T IW + K EK +V SW ++ Sbjct: 231 VSFAVFHPTLPI---IISGSEDGTLKIWNS---------STYKVEKTLNVGLERSWCIAT 278 Query: 266 -----GNVLALSGGDNKVTL 280 N +A SG DN T+ Sbjct: 279 HPTGRKNYIA-SGFDNGFTV 297 >3JB9-L nrPDB Length = 340 Score = 33.1 bits (74), Expect = 0.17, Method: Compositional matrix adjust. Identities = 32/134 (23%), Positives = 56/134 (41%), Gaps = 15/134 (11%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEV------EGETHKLIDTLTGHEGPVW 57 + H ++I + G L + S D T++IF+V + + + G E + Sbjct: 214 VLKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLL 273 Query: 58 RVDWAHPKFGTILASCSYDGKVLIWKEENG-RWSQIAVHAVHSASVNSVQWAPHEYGPLL 116 V W+ + + + S D V +W R+ V H SVN V + PH+ ++ Sbjct: 274 GVAWS--RNSRFVGAGSSDKNVYVWSATGDLRY----VLPGHEGSVNHVDFHPHQ--DII 325 Query: 117 LVASSDGKVSVVEF 130 L SSD + + E Sbjct: 326 LSCSSDRTIFLGEL 339 Score = 31.6 bits (70), Expect = 0.47, Method: Compositional matrix adjust. Identities = 59/274 (21%), Positives = 103/274 (37%), Gaps = 40/274 (14%) Query: 15 AVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCS 74 A D G A+ D+ I ++ V G+ K L G +G + + W+ ++ S Sbjct: 56 ARFDPSGSYFASGGMDRQILLWNVFGDV-KNYGVLNGCKGAITDLQWSRDS--RVVYCSS 112 Query: 75 YDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENG 134 D ++ W +G+ +I H H+ VN++ + G LL + SD V + Sbjct: 113 SDTHLMSWDAVSGQ--KIRKHKGHAGVVNALDVL--KVGSELLTSVSDDCTMKVWDSRSK 168 Query: 135 TTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTY 194 I + + + I + G + GG D +KIW ++ ++ Sbjct: 169 DCIKTIEEKYPL-------TAVAIAQQGT--------QVFIGGIDGAIKIWDLRNNHCSH 213 Query: 195 VLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFP 254 V L+GH D + +A S S L S S D T I+ + P+ + + F Sbjct: 214 V----LKGHKDIITSLAISKD---GSSLLSNSMDNTVRIF----DVKPFASAQRQLQIFE 262 Query: 255 DV-------LWRASWSLSGNVLALSGGDNKVTLW 281 L +WS + + D V +W Sbjct: 263 GAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVW 296 >3W15-A nrPDB Length = 368 Score = 32.7 bits (73), Expect = 0.18, Method: Compositional matrix adjust. Identities = 29/110 (26%), Positives = 43/110 (39%), Gaps = 20/110 (18%) Query: 175 TGGADNLVKIW---KYNSDA----QTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQ 227 TGG DN ++IW N + + + H +R V WSP + L S S Sbjct: 240 TGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPH--HSNILMSASY 297 Query: 228 DRTCIIWT-----------QDNEQGPWKKTLLKEEKFPDVLWRASWSLSG 266 D TC IW + N K ++ + + ++ A WSL G Sbjct: 298 DMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWG 347 Score = 28.9 bits (63), Expect = 3.2, Method: Compositional matrix adjust. Identities = 25/95 (26%), Positives = 42/95 (44%), Gaps = 17/95 (17%) Query: 6 NAHNELIHDAV----LDYYGKR---LATCSSDKTIKIFEVE------GETHK---LIDTL 49 N +N L+H + D+ R +AT D I+I+++ G+ H + + Sbjct: 213 NQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIP 272 Query: 50 TGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKE 84 H + +V W+ P IL S SYD IW++ Sbjct: 273 NAHGLAIRKVTWS-PHHSNILMSASYDMTCRIWRD 306 >6HHQ-h nrPDB Length = 319 Score = 32.7 bits (73), Expect = 0.21, Method: Compositional matrix adjust. Identities = 22/54 (40%), Positives = 31/54 (57%), Gaps = 10/54 (18%) Query: 192 QTYVLESTLEGHSDWVRDVAWS---PTVLLRSYLASVSQDRTCIIW--TQDNEQ 240 + VL TLEGH+ WV +A S P +LL S S+D+T I W T D+++ Sbjct: 5 EVLVLRGTLEGHNGWVTSLATSAGQPNLLL-----SASRDKTLISWKLTGDDQK 53 Score = 27.7 bits (60), Expect = 6.0, Method: Compositional matrix adjust. Identities = 14/47 (29%), Positives = 22/47 (46%), Gaps = 5/47 (10%) Query: 168 KESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSP 214 K++ ++G D +K+W +TL GH+DWV V P Sbjct: 117 KKASMIISGSRDKTIKVWTIKGQCL-----ATLLGHNDWVSQVRVVP 158 Score = 26.9 bits (58), Expect = 10.0, Method: Compositional matrix adjust. Identities = 33/124 (26%), Positives = 57/124 (45%), Gaps = 15/124 (12%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRV-----DWA 62 H + +D + + S DKTIK++ ++G+ + TL GH V +V + A Sbjct: 106 HKSDVMSVDIDKKASMIISGSRDKTIKVWTIKGQC---LATLLGHNDWVSQVRVVPNEKA 162 Query: 63 HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAV-HSASVNSVQWAPHEYGPLLLVASS 121 TI+ S D V W N QI + H++++N++ +P G L+ A Sbjct: 163 DDDSVTII-SAGNDKMVKAW---NLNQFQIEADFIGHNSNINTLTASPD--GTLIASAGK 216 Query: 122 DGKV 125 DG++ Sbjct: 217 DGEI 220 >4U1E-I nrPDB Length = 347 Score = 32.0 bits (71), Expect = 0.30, Method: Compositional matrix adjust. Identities = 49/222 (22%), Positives = 88/222 (39%), Gaps = 30/222 (13%) Query: 21 GKRLATCSSDKTIKI-FEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKV 79 G L +CS D + + + + GE + TL GH G +W +D F + S D + Sbjct: 22 GDLLFSCSKDSSASVWYSLNGER---LGTLDGHTGTIWSIDV--DCFTKYCVTGSADYSI 76 Query: 80 LIWKEENGRWSQIAVHAVHSASVNSVQWAP-HEYGPLLL--VASSDGKVSVVEFKENGTT 136 +W NG Q V V+++P Y +L V + G +++ E + + T Sbjct: 77 KLWDVSNG---QCVATWKSPVPVKRVEFSPCGNYFLAILDNVMKNPGSINIYEIERDSAT 133 Query: 137 SPIIIDAHAIGVNSASWAPATIEEDGEHNGT-----KESRKFVTGGADNLVKIWKYNSDA 191 H + S I +G T + + + G D KI KY+ + Sbjct: 134 -------HELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDG--KISKYDV-S 183 Query: 192 QTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII 233 Y +++ H + D+ +SP + +Y + S+D + Sbjct: 184 NNYEYVDSIDLHEKSISDMQFSPDL---TYFITSSRDTNSFL 222 >6J6H-n nrPDB Length = 455 Score = 32.0 bits (71), Expect = 0.32, Method: Compositional matrix adjust. Identities = 56/264 (21%), Positives = 102/264 (38%), Gaps = 33/264 (12%) Query: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 G + + +D TIKI++ + L D GH P+ + + S S+D V Sbjct: 175 GHLILSGGNDHTIKIWDFYHDYECLRD-FQGHNKPIKALRFTED--CQSFLSSSFDRSVK 231 Query: 81 IWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII 140 IW E G+ A V S PHE+ +V S+ K ++ + + + + + Sbjct: 232 IWDTETGKVKTRLHLNSTPADVESRPTNPHEF----IVGLSNSK--ILHYDDRVSENQGL 285 Query: 141 I---DAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLE 197 + D H + + + P DG KF++ D V+IW+ + + Sbjct: 286 VQTYDHHLSSILALKYFP-----DGS--------KFISSSEDKTVRIWENQINVPIKQIS 332 Query: 198 STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVL 257 T + HS +V S ++Y + S D ++ + K + K Sbjct: 333 DTAQ-HSMPFLNVHPS-----QNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHS--SAG 384 Query: 258 WRASWSLSGNVLALSGGDNKVTLW 281 + S + SG+ + GD+K L+ Sbjct: 385 YGISLAFSGDGRYICSGDSKSRLF 408 >5TF2-A nrPDB Length = 407 Score = 31.6 bits (70), Expect = 0.41, Method: Compositional matrix adjust. Identities = 21/68 (30%), Positives = 29/68 (42%), Gaps = 12/68 (17%) Query: 173 FVTGGADNLVKIWKYNSDAQTYVLESTLE--GHSDWVRDVAWSPTVLLRSYLASVSQDRT 230 TGG D V++WK S LE LE H + D+A P L +V +D Sbjct: 187 LATGGTDGYVRVWKVPS------LEKVLEFKAHEGEIEDLALGPD----GKLVTVGRDLK 236 Query: 231 CIIWTQDN 238 +W +D Sbjct: 237 ASVWQKDQ 244 >5WBU-D nrPDB Length = 328 Score = 31.6 bits (70), Expect = 0.48, Method: Compositional matrix adjust. Identities = 31/121 (25%), Positives = 48/121 (39%), Gaps = 18/121 (14%) Query: 69 ILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 ILA+ YD V W+ +G ++ H + VN+++ P ++ A+ + + Sbjct: 16 ILATAGYDHTVRFWQAHSGICTRTVQH--QDSQVNALEVTPDRS---MIAAAGYQHIRMY 70 Query: 129 EFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN 188 + N I D GVN + A EDG R TGG D +IW Sbjct: 71 DLNSNNPNPIISYD----GVNK-NIASVGFHEDG--------RWMYTGGEDCTARIWDLR 117 Query: 189 S 189 S Sbjct: 118 S 118 >4PSX-B nrPDB Length = 401 Score = 31.6 bits (70), Expect = 0.48, Method: Compositional matrix adjust. Identities = 24/99 (24%), Positives = 44/99 (44%), Gaps = 14/99 (14%) Query: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 LA D + ++++ L ++GHE V ++++ G +++S S D ++++W Sbjct: 267 LAAAGMDSYVYLYDLRNMKEPL-HHMSGHEDAVNNLEFSTHVDGVVVSSGS-DNRLMMWD 324 Query: 84 ------------EENGRWSQIAVHAVHSASVNSVQWAPH 110 E+G I VHA H +SVN P Sbjct: 325 LKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQ 363 >4G56-B nrPDB Length = 357 Score = 31.6 bits (70), Expect = 0.48, Method: Compositional matrix adjust. Identities = 27/124 (21%), Positives = 50/124 (40%), Gaps = 4/124 (3%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 H++++ + G + + D ++K++++ + ++ + H V V A P Sbjct: 138 HDDIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQKA--VLKSYNAHSSEVNCVA-ACPGKD 194 Query: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 TI SC DG++L+W + + SV W P E G VS+ Sbjct: 195 TIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHP-EKDDTFACGDETGNVSL 253 Query: 128 VEFK 131 V K Sbjct: 254 VNIK 257 >5OQL-L nrPDB Length = 557 Score = 31.2 bits (69), Expect = 0.63, Method: Compositional matrix adjust. Identities = 46/170 (27%), Positives = 71/170 (41%), Gaps = 29/170 (17%) Query: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG--TILASCSYDGKVLI 81 L +CS DKT++++++ + TGH V R P +L S SYD V + Sbjct: 160 LMSCSDDKTVRLWDLPSNDPTRL--FTGHTDYV-RCGAFMPGSANSNLLVSGSYDETVRV 216 Query: 82 WKEENGRWSQIAVHAV-HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI- 139 W + R AV H+ + V P G LL AS + +SV++ P+ Sbjct: 217 W---DARAPGGAVMTFKHADPIEDV--LPLPSGTTLLAASGNA-ISVLDLV---AAKPLR 267 Query: 140 IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNS 189 +I H V S S A + R+ V+G D VK+++ S Sbjct: 268 LITNHQKTVTSLSLA-------------SQGRRVVSGSLDGHVKVFETTS 304 Score = 30.8 bits (68), Expect = 0.74, Method: Compositional matrix adjust. Identities = 20/63 (31%), Positives = 31/63 (49%), Gaps = 2/63 (3%) Query: 21 GKRLATCSSDKTIKIFEV-EGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKV 79 G+ L +++F+V +G ++ T H+ PVW W+ P T L SCS D V Sbjct: 111 GRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWS-PTELTTLMSCSDDKTV 169 Query: 80 LIW 82 +W Sbjct: 170 RLW 172 Score = 30.0 bits (66), Expect = 1.1, Method: Compositional matrix adjust. Identities = 18/56 (32%), Positives = 27/56 (48%), Gaps = 4/56 (7%) Query: 179 DNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 D V++W S+ T + GH+D+VR A+ P + L S S D T +W Sbjct: 166 DKTVRLWDLPSNDPTRLFT----GHTDYVRCGAFMPGSANSNLLVSGSYDETVRVW 217 >6Q8F-A nrPDB Length = 514 Score = 30.8 bits (68), Expect = 0.65, Method: Compositional matrix adjust. Identities = 28/121 (23%), Positives = 52/121 (42%), Gaps = 18/121 (14%) Query: 69 ILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 +LA+ + DGK+ +WK ++G+ + HS V + ++ +L AS D + + Sbjct: 279 MLATGAQDGKIKVWKIQSGQCLR-RFERAHSKGVTCLSFSKD--SSQILSASFDQTIRIH 335 Query: 129 EFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN 188 K T H+ VN A++ +DG + ++ +D VKIW Sbjct: 336 GLKSGKTLKE--FRGHSSFVNEATFT-----QDGHY--------IISASSDGTVKIWNMK 380 Query: 189 S 189 + Sbjct: 381 T 381 >5OQL-X nrPDB Length = 630 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 39/152 (25%), Positives = 56/152 (36%), Gaps = 28/152 (18%) Query: 91 QIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNS 150 +I + N + H PL++ AS DGK V G +++ N+ Sbjct: 226 RICFAKADARKANDKTYQGHLKAPLVVKASQDGKFVVT----GGADKRLVV------YNA 275 Query: 151 ASWAPATIEEDGEHNGTKESRKFVTG-------GADNLVKIWKYNSDAQTYVLESTLEGH 203 A P I+ +H F G D VK+W D YV TL GH Sbjct: 276 ADLKP--IKAFTQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSL--DELAYV--ETLFGH 329 Query: 204 SDWVRDVAWSPTVLLRSYLASV-SQDRTCIIW 234 D + D+ L + SV ++DRT W Sbjct: 330 QDEILDI----DALGQERCVSVGARDRTARYW 357 >5K0Y-T nrPDB Length = 329 Score = 30.0 bits (66), Expect = 1.2, Method: Compositional matrix adjust. Identities = 33/133 (24%), Positives = 56/133 (42%), Gaps = 20/133 (15%) Query: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKI-FEVEGETHKLIDTLTGHEGPVWRV-- 59 ++ H I + G L T + D + + + V GE + T GH G VW V Sbjct: 4 ILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGER---LGTYMGHTGAVWCVDA 60 Query: 60 --DWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLL 117 D H G+ SC +W E G+ Q+A+ +SA V+ ++G ++ Sbjct: 61 DWDTKHVLTGSADNSCR------LWDCETGK--QLALLKTNSA----VRTCGFDFGGNII 108 Query: 118 VASSDGKVSVVEF 130 + S+D ++ F Sbjct: 109 MFSTDKQMGYQCF 121 >5CXC-A nrPDB Length = 510 Score = 30.0 bits (66), Expect = 1.2, Method: Compositional matrix adjust. Identities = 22/58 (37%), Positives = 31/58 (53%), Gaps = 12/58 (20%) Query: 162 GEHNGTKESRKFVT------GGADNLVKIWKYN-SDAQTYVLESTLE--GHS---DWV 207 G H + ++ KF+T G D V++WKY SD T L+ TLE GH+ DW+ Sbjct: 189 GGHTASIKAAKFLTSDRLASAGMDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWL 246 >5BJS-A nrPDB Length = 605 Score = 29.6 bits (65), Expect = 1.5, Method: Compositional matrix adjust. Identities = 27/88 (30%), Positives = 41/88 (46%), Gaps = 5/88 (5%) Query: 196 LESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT--QDNEQGPWKKTLLKEEKF 253 L TL GH + D+A SP +AS S D T IW+ ++E+ P L E Sbjct: 170 LYRTLVGHGGGINDLATSPANPY--IIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHS 227 Query: 254 PDVLWRASWSLSGNVLALSGGDNKVTLW 281 D+L ++ +G + +G D + LW Sbjct: 228 YDLL-SVAFHDNGRYVLSAGHDQVINLW 254 >4J0X-A nrPDB Length = 451 Score = 29.3 bits (64), Expect = 2.1, Method: Compositional matrix adjust. Identities = 19/62 (30%), Positives = 29/62 (46%), Gaps = 9/62 (14%) Query: 183 KIWKYNSDAQTYV------LESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ 236 K KY Y+ E+T EGH D + VA SP Y+ + +DR I+W+ Sbjct: 87 KKLKYAKGGAKYIPTSKHEYENTTEGHYDEILTVAASPD---GKYVVTGGRDRKLIVWST 143 Query: 237 DN 238 ++ Sbjct: 144 ES 145 >4KIC-A nrPDB Length = 357 Score = 29.3 bits (64), Expect = 2.3, Method: Compositional matrix adjust. Identities = 24/100 (24%), Positives = 40/100 (40%), Gaps = 4/100 (4%) Query: 144 HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGH 203 +GV+ A A A E++ G + FV G A + ++ A+ +L + GH Sbjct: 204 RGLGVDIADGAIAMAEKEVAAKGFGDQISFVRGDARTIDQVSARGEFAEVDLLTCFMMGH 263 Query: 204 SDWVRDVAWSPTVLLRSYLASVSQ----DRTCIIWTQDNE 239 W R+ LR+ +V + D T + D E Sbjct: 264 DFWPRENCVQTLRKLRAAFPNVRRFLLGDATRTVGIPDRE 303 >5WLC-SG nrPDB Length = 573 Score = 28.9 bits (63), Expect = 2.6, Method: Compositional matrix adjust. Identities = 15/39 (38%), Positives = 22/39 (56%), Gaps = 3/39 (7%) Query: 197 ESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 E+T EGH D + VA SP Y+ + +DR I+W+ Sbjct: 229 ENTTEGHYDEILTVAASPDG---KYVVTGGRDRKLIVWS 264 >5WYK-BB nrPDB Length = 943 Score = 28.9 bits (63), Expect = 2.7, Method: Compositional matrix adjust. Identities = 22/56 (39%), Positives = 29/56 (51%), Gaps = 7/56 (12%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKI--FEVE-----GETHKLIDTLTGH 52 I +AH+ I L GKRL T S+DKT+K F+VE G +K + L H Sbjct: 468 IEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLH 523 Score = 28.1 bits (61), Expect = 4.9, Method: Compositional matrix adjust. Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 12/73 (16%) Query: 17 LDYYGKRLATCSSDKTIKIFEVE-GETHKLIDTLTGHEGPVWRVDW---AHPKFGTILAS 72 + + K + T S+DK IKI+ ++ G+ HK +L H+ + V + +H F S Sbjct: 581 ISFDSKMIITSSADKNIKIWGLDFGDCHK---SLFAHQDSIMNVKFLPQSHNFF-----S 632 Query: 73 CSYDGKVLIWKEE 85 CS D V W E Sbjct: 633 CSKDAVVKYWDGE 645 Score = 27.3 bits (59), Expect = 8.2, Method: Compositional matrix adjust. Identities = 33/131 (25%), Positives = 51/131 (38%), Gaps = 29/131 (22%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGE-------THKLIDTLTGH--EGPV 56 N H I D G RL + S D I ++++ GE +HK D++TG +G Sbjct: 118 NGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYKLRSHK--DSITGFWCQGED 175 Query: 57 WRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLL 116 W L S S DG + +W + + I H H+ W LL Sbjct: 176 W------------LISTSKDGMIKLWDLKTHQC--IETHIAHTGEC----WGLAVKDDLL 217 Query: 117 LVASSDGKVSV 127 + +D +V + Sbjct: 218 ITTGTDSQVKI 228 >4OWR-A nrPDB Length = 339 Score = 28.9 bits (63), Expect = 2.9, Method: Compositional matrix adjust. Identities = 24/109 (22%), Positives = 46/109 (42%), Gaps = 8/109 (7%) Query: 33 IKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQI 92 ++ +EV+ + H GPV V W+ ASC D +W + + QI Sbjct: 37 VRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASC--DKTAKMWDLSSNQAIQI 94 Query: 93 AVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIII 141 A H A V ++ W ++ S D ++F + +++P+++ Sbjct: 95 ---AQHDAPVKTIHWIKAPNYSCVMTGSWD---KTLKFWDTRSSNPMMV 137 >4NOX-A nrPDB Length = 746 Score = 28.9 bits (63), Expect = 3.0, Method: Compositional matrix adjust. Identities = 32/137 (23%), Positives = 55/137 (40%), Gaps = 20/137 (14%) Query: 43 HKLIDTLTGHEGPVWRVDWAH-----PKFGTILASCSYDGK-VLIWKEENGR-WSQIAVH 95 H ++ + G + V W++ P G + + DGK +IW E R A Sbjct: 237 HPFVNLVAFSPGEKYLVTWSNRPIQIPDSGHPVLTLDDDGKNYIIWDIETARPLRSFAQQ 296 Query: 96 AVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI-------IIDAHAI-- 146 +H + P P+ ++ D V+ + GT+ I ++D A+ Sbjct: 297 DIHPEEHGPKKGPPKFPWPVFKWSADDKYVARLN---QGTSISIYELPKMNLLDKQAVKI 353 Query: 147 -GVNSASWAPATIEEDG 162 GV WAPAT++ +G Sbjct: 354 EGVMDFEWAPATVQREG 370 >5MOG-A nrPDB Length = 497 Score = 28.5 bits (62), Expect = 4.1, Method: Compositional matrix adjust. Identities = 17/68 (25%), Positives = 28/68 (41%), Gaps = 14/68 (20%) Query: 77 GKVLIWKEENGRWSQIAVHAVHSASVN------------SVQWAPHEYGPLLLVASSDGK 124 GK+ WK+E+G W + +H A N +QW H + + + G+ Sbjct: 54 GKIAAWKDEDGDWYETGLHIFFGAYPNIQNLFGELGINDRLQWKEHSM--IFAMPNKPGE 111 Query: 125 VSVVEFKE 132 S +F E Sbjct: 112 FSRFDFPE 119 >4RUH-A nrPDB Length = 475 Score = 28.1 bits (61), Expect = 4.2, Method: Compositional matrix adjust. Identities = 15/64 (23%), Positives = 26/64 (40%), Gaps = 13/64 (20%) Query: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 ++ N E++ + V Y K+ A S K++ GH G W D++ Sbjct: 344 LVPNMTPEVVGEQVTSYLTKKFAELRSPNEFKVY-------------MGHGGKPWVSDFS 390 Query: 63 HPKF 66 HP + Sbjct: 391 HPHY 394 >6C0F-s nrPDB Length = 807 Score = 28.1 bits (61), Expect = 4.5, Method: Compositional matrix adjust. Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 6/78 (7%) Query: 202 GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDV-LWRA 260 GH VR ++ P+ L +LA+ S D T +W + ++ TL+ +E+ PD + Sbjct: 435 GHKGKVRTLSIDPSGL---WLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECI 491 Query: 261 SWSLSGN--VLALSGGDN 276 W+ N +LA++ G+N Sbjct: 492 EWNPDANNGILAVAVGEN 509 >5WLC-LU nrPDB Length = 489 Score = 28.1 bits (61), Expect = 4.6, Method: Compositional matrix adjust. Identities = 50/272 (18%), Positives = 111/272 (40%), Gaps = 44/272 (16%) Query: 24 LATCSSDKTIKI--FEVEGETHKLI---DTLTGHEGPVWRVDW--------AHPKFGTIL 70 + +CS DKT+K+ V+ ++K D++T EG + D +H + T Sbjct: 136 MLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQGIDSHRENSTFA 195 Query: 71 ASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEF 130 + K+ +W + R ++ + + ++ S+++ +E +L SD + + + Sbjct: 196 TGGA---KIHLW--DVNRLKPVSDLSWGADNITSLKFNQNE-TDILASTGSDNSIVLYDL 249 Query: 131 KENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSD 190 + N T I+ + N+ W P E+ FVT D+ + + Sbjct: 250 RTNSPTQKIV---QTMRTNAICWNPM------------EAFNFVTANEDHNAYYYDMRNL 294 Query: 191 AQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKE 250 +++ + + H V DV +SPT + + S D++ I+ ++ + + Sbjct: 295 SRSL---NVFKDHVSAVMDVDFSPTG---DEIVTGSYDKSIRIYKTNHGHS---REIYHT 345 Query: 251 EKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 ++ V ++ +S+ + D V LW+ Sbjct: 346 KRMQHV-FQVKYSMDSKYIISGSDDGNVRLWR 376 >6CB1-s nrPDB Length = 569 Score = 28.1 bits (61), Expect = 4.7, Method: Compositional matrix adjust. Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 6/78 (7%) Query: 202 GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDV-LWRA 260 GH VR ++ P+ L +LA+ S D T +W + ++ TL+ +E+ PD + Sbjct: 197 GHKGKVRTLSIDPSGL---WLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECI 253 Query: 261 SWSLSGN--VLALSGGDN 276 W+ N +LA++ G+N Sbjct: 254 EWNPDANNGILAVAVGEN 271 >6EM1-m nrPDB Length = 807 Score = 28.1 bits (61), Expect = 4.8, Method: Compositional matrix adjust. Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 6/78 (7%) Query: 202 GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDV-LWRA 260 GH VR ++ P+ L +LA+ S D T +W + ++ TL+ +E+ PD + Sbjct: 435 GHKGKVRTLSIDPSGL---WLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECI 491 Query: 261 SWSLSGN--VLALSGGDN 276 W+ N +LA++ G+N Sbjct: 492 EWNPDANNGILAVAVGEN 509 >2AS0-A nrPDB Length = 396 Score = 27.7 bits (60), Expect = 6.6, Method: Compositional matrix adjust. Identities = 15/55 (27%), Positives = 28/55 (50%), Gaps = 1/55 (1%) Query: 144 HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGA-DNLVKIWKYNSDAQTYVLE 197 IG++ + A T +E+ + NG ++ KF+ G A + + K+ K VL+ Sbjct: 242 EVIGIDKSPRAIETAKENAKLNGVEDRMKFIVGSAFEEMEKLQKKGEKFDIVVLD 296 >2ZYL-A nrPDB Length = 386 Score = 27.3 bits (59), Expect = 8.0, Method: Compositional matrix adjust. Identities = 13/41 (31%), Positives = 23/41 (56%), Gaps = 7/41 (17%) Query: 40 GETHKLIDTLTGHEGPVWRVDWAHPKFG-----TILASCSY 75 GE H +D+ + GP + ++W H ++G +IL +C Y Sbjct: 222 GEAH--LDSEASYFGPSFMINWLHNRYGNYKSESILINCHY 260 >2GBG-A nrPDB Length = 730 Score = 26.9 bits (58), Expect = 9.6, Method: Compositional matrix adjust. Identities = 32/138 (23%), Positives = 56/138 (40%), Gaps = 32/138 (23%) Query: 172 KFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLL------------R 219 +++ +N++ + ++ ++ ST E D + D + SP L Sbjct: 28 EYLYKQENNILLFNAEHGNSSIFLENSTFEIFGDSISDYSVSPDRLFVLLEYNYVKQWRH 87 Query: 220 SYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVT 279 SY AS S I+ + K+ L+ EEK P+ +WS G+ LA Sbjct: 88 SYTASYS------IYDLN------KRQLITEEKIPNNTQWITWSQEGHKLAY-------- 127 Query: 280 LWKENLEGKWEPAGEVHQ 297 +WK ++ K EP H+ Sbjct: 128 VWKNDIYVKIEPHLPSHR 145 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3JRO-A nrPDB 399 e-112 3JRP-A nrPDB 378 e-105 4BZK-B nrPDB 367 e-102 4L9O-A nrPDB 329 1e-90 4YCZ-A nrPDB 328 2e-90 3BG0-A nrPDB 273 7e-74 5A9Q-7 nrPDB 218 3e-57 1VYH-C nrPDB 214 4e-56 5MZH-A nrPDB 208 3e-54 5OQL-J nrPDB 203 7e-53 6QX9-5O nrPDB 203 8e-53 5NNZ-B nrPDB 200 5e-52 6HQA-B nrPDB 192 1e-49 3FM0-A nrPDB 190 8e-49 3F3P-A nrPDB 185 3e-47 5YZG-W nrPDB 183 8e-47 6QDV-o nrPDB 183 1e-46 6MZM-G nrPDB 178 2e-45 6F3T-A nrPDB 177 4e-45 5FL8-q nrPDB 172 2e-43 4V6W-Ag nrPDB 170 7e-43 5M25-A nrPDB 169 2e-42 5GAN-H nrPDB 167 5e-42 3DM0-A nrPDB 167 6e-42 6G51-g nrPDB 166 7e-42 5Y1U-A nrPDB 166 8e-42 6QX9-4B nrPDB 165 2e-41 3C9C-A nrPDB 162 2e-40 2H9P-A nrPDB 161 3e-40 2HES-X nrPDB 160 6e-40 6N9G-C nrPDB 158 2e-39 5WJC-A nrPDB 155 2e-38 4XFV-A nrPDB 155 2e-38 3CFV-B nrPDB 154 4e-38 4BTS-AR nrPDB 153 1e-37 5WYJ-BC nrPDB 148 2e-36 3JB9-g nrPDB 147 5e-36 4XYI-A nrPDB 143 9e-35 5L9T-R nrPDB 143 1e-34 5NZU-C nrPDB 142 2e-34 6EMK-B nrPDB 139 2e-33 5FVM-C nrPDB 134 3e-32 6EOJ-D nrPDB 132 2e-31 6GMH-W nrPDB 124 3e-29 5FA5-B nrPDB 124 6e-29 5Y88-O nrPDB 115 2e-26 5K1B-B nrPDB 111 5e-25 2AQ5-A nrPDB 110 8e-25 5WLC-LO nrPDB 109 1e-24 5I2T-A nrPDB 107 4e-24 2P9P-C nrPDB 101 5e-22 3DWL-C nrPDB 98 4e-21 5A9Q-2 nrPDB 82 3e-16 Sequences not found previously or not previously below threshold: 6ID0-T nrPDB 140 5e-34 4V8M-A7 nrPDB 136 1e-32 3MKQ-A nrPDB 135 3e-32 6HHQ-h nrPDB 131 3e-31 5OPT-p nrPDB 131 4e-31 2YNP-A nrPDB 131 4e-31 3JAP-g nrPDB 128 2e-30 5Z56-q nrPDB 127 7e-30 3JB9-L nrPDB 124 5e-29 6Q8F-A nrPDB 123 8e-29 4LG8-A nrPDB 122 2e-28 6J6H-n nrPDB 120 6e-28 5UZ7-B nrPDB 119 1e-27 5OQL-d nrPDB 119 1e-27 5G04-R nrPDB 116 2e-26 4GGA-A nrPDB 112 1e-25 5LCW-Q nrPDB 111 3e-25 4V7E-Bg nrPDB 111 4e-25 5WLC-LU nrPDB 108 4e-24 4N14-A nrPDB 107 7e-24 5XYI-g nrPDB 104 5e-23 4J0W-A nrPDB 103 9e-23 6BX3-A nrPDB 102 3e-22 3ODT-A nrPDB 101 4e-22 4A11-B nrPDB 100 6e-22 5WYK-BB nrPDB 100 7e-22 4G56-B nrPDB 100 7e-22 5WBU-D nrPDB 100 8e-22 3W15-A nrPDB 96 1e-20 6ELZ-p nrPDB 94 5e-20 6F1U-h nrPDB 94 8e-20 6CHG-A nrPDB 91 4e-19 4PSX-B nrPDB 91 4e-19 5K0Y-T nrPDB 89 2e-18 4AEZ-A nrPDB 89 2e-18 4OWR-A nrPDB 89 3e-18 5A31-R nrPDB 89 3e-18 4U1E-I nrPDB 88 3e-18 4BH6-A nrPDB 86 2e-17 1NR0-A nrPDB 86 2e-17 3ACP-A nrPDB 83 1e-16 5CXC-A nrPDB 82 4e-16 5WYJ-BE nrPDB 81 4e-16 6E29-D nrPDB 81 5e-16 5N4A-A nrPDB 81 7e-16 5OQL-X nrPDB 81 8e-16 3JZG-A nrPDB 79 2e-15 5BJS-A nrPDB 77 1e-14 5WLC-LJ nrPDB 76 2e-14 2PM9-A nrPDB 75 4e-14 5OQL-L nrPDB 74 8e-14 6EM1-m nrPDB 73 1e-13 6BX3-B nrPDB 73 1e-13 6C0F-s nrPDB 73 2e-13 6CB1-s nrPDB 72 2e-13 5CXB-B nrPDB 69 2e-12 5MWJ-A nrPDB 69 3e-12 4E5Z-B nrPDB 68 6e-12 5YZG-2 nrPDB 67 1e-11 5WLC-SG nrPDB 66 2e-11 4J0X-A nrPDB 66 2e-11 5AMS-A nrPDB 66 3e-11 3I2N-A nrPDB 63 2e-10 1PI6-A nrPDB 62 4e-10 5A9Q-0 nrPDB 61 5e-10 5WLC-LN nrPDB 61 7e-10 5K19-A nrPDB 59 2e-09 5M89-A nrPDB 59 3e-09 5OV3-A nrPDB 58 4e-09 6CHG-D nrPDB 58 4e-09 3DW8-B nrPDB 58 4e-09 5WLC-LS nrPDB 55 4e-08 5MC6-j nrPDB 53 1e-07 2I3T-A nrPDB 53 2e-07 5TF2-A nrPDB 49 2e-06 3EI3-B nrPDB 49 3e-06 4AV8-A nrPDB 48 5e-06 6CVZ-A nrPDB 48 7e-06 5WLC-LH nrPDB 43 2e-04 4FHN-A nrPDB 42 2e-04 5WLC-LW nrPDB 42 3e-04 6IYY-A nrPDB 41 5e-04 2VDU-B nrPDB 39 0.002 3JB9-S nrPDB 38 0.005 4YHC-A nrPDB 37 0.011 5GRS-A nrPDB 36 0.019 6N8P-A nrPDB 35 0.034 5CWW-B nrPDB 32 0.23 2DFV-A nrPDB 30 1.4 5LTD-A nrPDB 29 1.9 6C94-A nrPDB 29 2.7 5BPT-A nrPDB 29 3.5 5KIA-A nrPDB 28 4.1 1OI2-A nrPDB 28 4.6 3TKN-A nrPDB 28 4.8 1D0M-A nrPDB 28 5.0 2XZ5-A nrPDB 27 7.0 1X3Z-A nrPDB 27 7.4 1S18-A nrPDB 27 7.4 >3JRO-A nrPDB Length = 753 Score = 399 bits (1026), Expect = e-112, Method: Composition-based stats. Identities = 297/297 (100%), Positives = 297/297 (100%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD Sbjct: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS Sbjct: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN Sbjct: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 Query: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ Sbjct: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 Query: 241 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ Sbjct: 241 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 >3JRP-A nrPDB Length = 379 Score = 378 bits (970), Expect = e-105, Method: Composition-based stats. Identities = 297/297 (100%), Positives = 297/297 (100%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD Sbjct: 3 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 62 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS Sbjct: 63 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 122 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN Sbjct: 123 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 182 Query: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ Sbjct: 183 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 242 Query: 241 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ Sbjct: 243 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 299 >4BZK-B nrPDB Length = 297 Score = 367 bits (943), Expect = e-102, Method: Composition-based stats. Identities = 297/297 (100%), Positives = 297/297 (100%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD Sbjct: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS Sbjct: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN Sbjct: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 Query: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ Sbjct: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 Query: 241 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ Sbjct: 241 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 >4L9O-A nrPDB Length = 349 Score = 329 bits (843), Expect = 1e-90, Method: Composition-based stats. Identities = 202/296 (68%), Positives = 245/296 (82%), Gaps = 8/296 (2%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 V I NAH++LIHDAVLDYYG+RLATCSSDKTIKIFE++GE +L++TL GHEGPVW+V W Sbjct: 62 VTIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAW 121 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 AHPKFG ILASCSYDGKVLIWKE+NG W+++A H+VH ASVNSV WAPHEYGP+LL ASS Sbjct: 122 AHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASS 181 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 DGK+S+VEFK+ G PI+I HAIGVN+ASWAP ++ +R+FV+GG DNL Sbjct: 182 DGKISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLP--------DNTRRFVSGGCDNL 233 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQG 241 VKIW+Y+ A+T++ E +GHSDWVRDVAWSP+ L +SY+A+ SQDRT +IWT+D + Sbjct: 234 VKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSN 293 Query: 242 PWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 W+K L +EKFPDV WRASWSLSGNVLA+SGGDNKVTLWKEN++GKWE AGEV Q Sbjct: 294 KWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLWKENIQGKWESAGEVDQ 349 >4YCZ-A nrPDB Length = 876 Score = 328 bits (840), Expect = 2e-90, Method: Composition-based stats. Identities = 176/302 (58%), Positives = 213/302 (70%), Gaps = 10/302 (3%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 V+ + H+++IHDAVLDYYG+RLATCSSD+TIKIFE+EGET +L +TL GH+G VW V W Sbjct: 11 VIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSW 70 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 AHPK+G ILAS YDGKVLIW+E NG W +I A+H ASVN V W+PHE G LL ASS Sbjct: 71 AHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASS 130 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIE----EDGEHNGTKESRKFVTGG 177 DG VSV+EF++N + I AH +GVNS SWAPAT + +R+FVTGG Sbjct: 131 DGNVSVLEFRDN-SWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGG 189 Query: 178 ADNLVKIWKYNSDAQTYVLEST-LEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ 236 +DN +KIW Y+ TY LE L GH+DWVRDVAWSPTVL +SY+AS S+DRT IWT Sbjct: 190 SDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTS 249 Query: 237 DNEQG-PWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEV 295 D W +L F +WR SWSLSGNVLA SGGDNKVTLWKENL+G+WE + Sbjct: 250 DPANPLQWNCKVLN---FDAAVWRVSWSLSGNVLAASGGDNKVTLWKENLKGEWECVKTI 306 Query: 296 HQ 297 + Sbjct: 307 EE 308 >3BG0-A nrPDB Length = 316 Score = 273 bits (697), Expect = 7e-74, Method: Composition-based stats. Identities = 151/302 (50%), Positives = 197/302 (65%), Gaps = 10/302 (3%) Query: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 + +H ++IHDA +DYYG RLATCSSD+++KIF+V LI L GHEGPVW+V WA Sbjct: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA 66 Query: 63 HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD 122 HP +G ILASCSYD KV+IW+EENG W + HA H +SVNSV WAPH+YG +L SSD Sbjct: 67 HPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSD 126 Query: 123 GKVSVVEFKENGTTS-PIIIDAHAIGVNSASWAPATIEED----GEHNGTKESRKFVTGG 177 G +S++ + G I +AH IG N+ SWAPA + ++F +GG Sbjct: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGG 186 Query: 178 ADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV-LLRSYLASVSQDRTCIIWTQ 236 DNL+K+WK D Q + E LE HSDWVRDVAW+P++ L S +AS SQD IWT Sbjct: 187 CDNLIKLWKEEEDGQ-WKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTC 245 Query: 237 -DNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEV 295 D W LL KF DV+W SWS++ N+LA+SGGDNKVTLWKE+++G+W +V Sbjct: 246 DDASSNTWSPKLL--HKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDV 303 Query: 296 HQ 297 ++ Sbjct: 304 NK 305 >5A9Q-7 nrPDB Length = 360 Score = 218 bits (554), Expect = 3e-57, Method: Composition-based stats. Identities = 95/321 (29%), Positives = 151/321 (47%), Gaps = 39/321 (12%) Query: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEV-EGETHKLIDTLTGHEGPVWRVDW 61 IA H +LIHD D++G+R+ATCSSD+++K+++ E + H G VWRV W Sbjct: 6 SIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW 65 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGR----------WSQIAVHAVHSASVNSVQWAPHE 111 AHP+FG +LASCS+D +W+E G W + SV V++AP Sbjct: 66 AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKH 125 Query: 112 YGPLLLVASSDGKVSVVEFKENGTTSPIIIDA---HAIGVNSASWAPATIEEDGEHNGTK 168 G +L S+DG V + E + S + + + SW P++ ++ Sbjct: 126 MGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSS---------SR 176 Query: 169 ESRKFVTGGADNL-------VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLR-S 220 + G+D+ V+I++YN + + Y TL +D V D+A++P + Sbjct: 177 AHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFH 236 Query: 221 YLASVSQDRTCIIWTQDNEQ-----GPWKKTLLKEEKFPDV---LWRASWSLSGNVLALS 272 LA ++D ++ GP K + +F + +WR SW+++G VLA S Sbjct: 237 ILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASS 296 Query: 273 GGDNKVTLWKENLEGKWEPAG 293 G D V LWK N W+ G Sbjct: 297 GDDGCVRLWKANYMDNWKCTG 317 Score = 40.2 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 15/76 (19%), Positives = 31/76 (40%), Gaps = 4/76 (5%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEG-ETHKLIDTLTGHEGPVWRV 59 +V + HN + + G LA+ D +++++ + K L G+ PV Sbjct: 270 IVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVNGS 329 Query: 60 D---WAHPKFGTILAS 72 ++P G+ + S Sbjct: 330 SQQGTSNPSLGSTIPS 345 Score = 37.9 bits (86), Expect = 0.005, Method: Composition-based stats. Identities = 9/44 (20%), Positives = 16/44 (36%) Query: 251 EKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGE 294 D++ S+ G +A D V +W ++ G W Sbjct: 9 ADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTAS 52 >1VYH-C nrPDB Length = 410 Score = 214 bits (544), Expect = 4e-56, Method: Composition-based stats. Identities = 71/286 (24%), Positives = 119/286 (41%), Gaps = 29/286 (10%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 H + + D D+ GK LA+CS+D TIK+++ +G + I T+ GH+ V V Sbjct: 145 TLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQG--FECIRTMHGHDHNVSSVSIMP 202 Query: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 G + S S D + +W+ + G + H V V+ P++ G L+ S+D Sbjct: 203 N--GDHIVSASRDKTIKMWEVQTGYC--VKTFTGHREWVRMVR--PNQDGTLIASCSNDQ 256 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRK-------FVTG 176 V V + + H V SWAP + E++K ++G Sbjct: 257 TVRVWVVATKECKAE--LREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSG 314 Query: 177 GADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ 236 D +K+W D T + TL GH +WVR V + ++ S + D+T +W Sbjct: 315 SRDKTIKMW----DVSTGMCLMTLVGHDNWVRGVLFHS---GGKFILSCADDKTLRVWDY 367 Query: 237 DNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 N++ KTL E F + + + + D V +W+ Sbjct: 368 KNKR--CMKTLNAHEHF---VTSLDFHKTAPYVVTGSVDQTVKVWE 408 Score = 143 bits (360), Expect = 9e-35, Method: Composition-based stats. Identities = 52/255 (20%), Positives = 88/255 (34%), Gaps = 46/255 (18%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 + + H+ + + G + + S DKTIK++EV +T + T TGH V V Sbjct: 184 CIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEV--QTGYCVKTFTGHREWVRMVR 241 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEY-------- 112 + GT++ASCS D V +W A H V + WAP Sbjct: 242 --PNQDGTLIASCSNDQTVRVWVVATKECK--AELREHRHVVECISWAPESSYSSISEAT 297 Query: 113 ----------GPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDG 162 GP LL S D + + + + + H V + Sbjct: 298 GSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCL--MTLVGHDNWVRGVLFH-------- 347 Query: 163 EHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYL 222 + ++ D +++W Y + TL H +V + + Y+ Sbjct: 348 -----SGGKFILSCADDKTLRVWDY----KNKRCMKTLNAHEHFVTSLDFH---KTAPYV 395 Query: 223 ASVSQDRTCIIWTQD 237 + S D+T +W Sbjct: 396 VTGSVDQTVKVWECR 410 Score = 129 bits (325), Expect = 1e-30, Method: Composition-based stats. Identities = 58/256 (22%), Positives = 95/256 (37%), Gaps = 53/256 (20%) Query: 49 LTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWA 108 L+GH PV RV + HP F +++ S S D + +W E G + + H+ SV + + Sbjct: 104 LSGHRSPVTRVIF-HPVF-SVMVSASEDATIKVWDYETGDFER--TLKGHTDSVQDISF- 158 Query: 109 PHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTK 168 G LL S+D + + +F+ G + H V+S S P Sbjct: 159 -DHSGKLLASCSADMTIKLWDFQ--GFECIRTMHGHDHNVSSVSIMP------------- 202 Query: 169 ESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQD 228 V+ D +K+W+ QT T GH +WVR V P + +AS S D Sbjct: 203 NGDHIVSASRDKTIKMWE----VQTGYCVKTFTGHREWVRMVR--PNQD-GTLIASCSND 255 Query: 229 RTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLS--------------------GNV 268 +T +W ++ + + V+ SW+ G Sbjct: 256 QTVRVWVVATKECKAELR-----EHRHVVECISWAPESSYSSISEATGSETKKSGKPGPF 310 Query: 269 LALSGGDNKVTLWKEN 284 L D + +W + Sbjct: 311 LLSGSRDKTIKMWDVS 326 Score = 98.0 bits (242), Expect = 4e-21, Method: Composition-based stats. Identities = 38/199 (19%), Positives = 74/199 (37%), Gaps = 29/199 (14%) Query: 83 KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIID 142 KE R + + H + V V + P +++ AS D + V +++ + Sbjct: 92 KEWIPRPPEKYALSGHRSPVTRVIFHP--VFSVMVSASEDATIKVWDYETGD--FERTLK 147 Query: 143 AHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEG 202 H V S+ + + AD +K+W + Q + T+ G Sbjct: 148 GHTDSVQDISFD-------------HSGKLLASCSADMTIKLWDF----QGFECIRTMHG 190 Query: 203 HSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASW 262 H V V+ P ++ S S+D+T +W + + G KT ++ ++ Sbjct: 191 HDHNVSSVSIMPN---GDHIVSASRDKTIKMW--EVQTGYCVKTFTGHREWVRMVRP--- 242 Query: 263 SLSGNVLALSGGDNKVTLW 281 + G ++A D V +W Sbjct: 243 NQDGTLIASCSNDQTVRVW 261 Score = 87.6 bits (215), Expect = 6e-18, Method: Composition-based stats. Identities = 31/183 (16%), Positives = 60/183 (32%), Gaps = 25/183 (13%) Query: 100 ASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIE 159 V ++ +E G+ + + H V + P Sbjct: 63 KKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPV--- 119 Query: 160 EDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLR 219 V+ D +K+W Y +T E TL+GH+D V+D+++ + Sbjct: 120 ----------FSVMVSASEDATIKVWDY----ETGDFERTLKGHTDSVQDISFDHS---G 162 Query: 220 SYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVT 279 LAS S D T +W + + + S +G+ + + D + Sbjct: 163 KLLASCSADMTIKLWDFQGFE-----CIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIK 217 Query: 280 LWK 282 +W+ Sbjct: 218 MWE 220 >5MZH-A nrPDB Length = 452 Score = 208 bits (528), Expect = 3e-54, Method: Composition-based stats. Identities = 66/310 (21%), Positives = 122/310 (39%), Gaps = 48/310 (15%) Query: 2 VVIANAHNELIHDAVLD-YYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 V H +++ + YG ++ T S DKT K+++ T +L TL GH+ + + Sbjct: 129 VFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAY--TGQLYYTLKGHQTEIVCLS 186 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 + TI+A+ S D +W E G+ + A A H A + S+ + + G L++ S Sbjct: 187 FNP--QSTIIATGSMDNTAKLWDVETGQ--ERATLAGHRAEIVSLGF--NTGGDLIVTGS 240 Query: 121 SDGKVSVVEFKENGTTSPI-----------------IIDAHAIGVNSASWAPATIEEDGE 163 D + + + + ++ + +I S W + Sbjct: 241 FDHDSRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSV 300 Query: 164 HNGTKE----------SRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWS 213 G + K V+ AD +++ T V + TL GH + VA++ Sbjct: 301 KQGHTDEVLDVAFDAAGTKMVSASADGSARLY----HTLTGVCQHTLVGHEGEISKVAFN 356 Query: 214 PTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSG 273 P + L + S D+TC +W D G + L E D ++ +++ G+ + Sbjct: 357 PQ---GTRLITASSDKTCRLWDCD--TGECLQVL---EGHTDEIFSCAFNYEGDFIITGS 408 Query: 274 GDNKVTLWKE 283 DN +WK Sbjct: 409 KDNTCRIWKA 418 Score = 117 bits (293), Expect = 5e-27, Method: Composition-based stats. Identities = 39/186 (20%), Positives = 70/186 (37%), Gaps = 23/186 (12%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 V + + H + +Y G + + S D T ++++V + + + GH V +D Sbjct: 255 CVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVR--SGRCLSVKQGHTDEV--LD 310 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 A GT + S S DG ++ G H ++ V + P G L+ AS Sbjct: 311 VAFDAAGTKMVSASADGSARLYHTLTGVCQ--HTLVGHEGEISKVAFNPQ--GTRLITAS 366 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 SD + + +++ H + S ++ E +TG DN Sbjct: 367 SDKTCRLWDCDTGECLQ--VLEGHTDEIFSCAFN-------------YEGDFIITGSKDN 411 Query: 181 LVKIWK 186 +IWK Sbjct: 412 TCRIWK 417 >5OQL-J nrPDB Length = 912 Score = 203 bits (516), Expect = 7e-53, Method: Composition-based stats. Identities = 74/310 (23%), Positives = 118/310 (38%), Gaps = 41/310 (13%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE--GETHKLIDTLTGHEGPVWRV 59 V + H +++ +D+ G +A+ S D T +++ V+ ++ TGH V V Sbjct: 426 VALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAV 485 Query: 60 ------------DWAHP--KFGTILASCSYDGKVLIWKE-----ENGRWSQIAVHAVHSA 100 + +P L S S D V + G+ + H Sbjct: 486 ALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDK 545 Query: 101 SVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEE 160 +N++ +P+ G L AS D V + + ++ I+ H GV + +AP Sbjct: 546 DINALDISPN--GKLFASASQDKTVKIWDVEK--LEVQGILRGHKRGVWTVRFAPLNTPV 601 Query: 161 DGEHNGTKESRKFV-TGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAW------S 213 G+ R V TG D +K+W + Y T EGHS V V W Sbjct: 602 IQGEQGSVSGRGVVLTGSGDKTIKLWNLSD----YTCIRTFEGHSHNVLKVVWLHISRDD 657 Query: 214 PTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSG 273 + AS D +W D G + TL E D LW + N+LA +G Sbjct: 658 SITKTKVQFASAGADTLVKVW--DANTGETECTLDNHE---DRLWTLAVHSKTNILASAG 712 Query: 274 GDNKVTLWKE 283 D+KVT W++ Sbjct: 713 SDSKVTFWRD 722 Score = 78.3 bits (191), Expect = 4e-15, Method: Composition-based stats. Identities = 46/290 (15%), Positives = 88/290 (30%), Gaps = 41/290 (14%) Query: 23 RLATCSSDKTIKIFEVEGETHKLI-----DTLTGHEGPVWRVDWAHPKFGTILASCSYDG 77 RLA + D I+IF++ T + HE V + ++ + L S S D Sbjct: 197 RLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHA--LLSGSRDK 254 Query: 78 KVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTS 137 + +W +G W + H + SV + G + A + G + + + Sbjct: 255 TMTLWLWRDGIWQGTPML-RHE-LLESVGFLNE--GKWMYSAGTSGVLRIWDTT------ 304 Query: 138 PIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLE 197 H I + + E E + AD + +++ S A Sbjct: 305 ----THHEITKKQDA--KSEGEAILSAVSLPERSLILCAQADFTLVLYRVPSPADVVSSS 358 Query: 198 STL--------EGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLK 249 + G D + D+ + +A+ S+D + Sbjct: 359 EGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRS 418 Query: 250 E----------EKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKW 289 + D++ SG+ +A DN LW+ + Sbjct: 419 GSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNS 468 Score = 76.4 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 53/330 (16%), Positives = 103/330 (31%), Gaps = 61/330 (18%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIF------EVEGETHKLIDTLTGHEGP 55 + E I + G L CS T++I+ + + L+ T H P Sbjct: 54 LAEIQGDGEPISTLTITPSGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATP 113 Query: 56 VWRVDWAHPKFGTILASCSYDGKVLIWKEENG------RWSQIAVHAVH--SASVNSVQW 107 V V A + T+LA+ + DG + IW G + V A+H +V + Sbjct: 114 V--VVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAESQ 171 Query: 108 APHEYGPL------------------LLVASSDGKVSVVEFKENGTTSPI-----IIDAH 144 + ++ L + DG++ + + + TT +AH Sbjct: 172 SSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAH 231 Query: 145 AIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHS 204 V +++P E ++G D + +W + E Sbjct: 232 ESNVQCIAYSP-------------EQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHE--- 275 Query: 205 DWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSL 264 + V + + ++ S IW KK K E + + A Sbjct: 276 -LLESVGF---LNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEG--EAILSAVSLP 329 Query: 265 SGNVLALSGGDNKVTLWKENLEGKWEPAGE 294 +++ + D + L++ + E Sbjct: 330 ERSLILCAQADFTLVLYRVPSPADVVSSSE 359 Score = 76.0 bits (185), Expect = 2e-14, Method: Composition-based stats. Identities = 49/346 (14%), Positives = 97/346 (28%), Gaps = 71/346 (20%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKI-----------------------------F 36 AH + L + S DKT+ + + Sbjct: 229 EAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGFLNEGKW 288 Query: 37 EVEGETHKLIDTL--TGH-----------EGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 T ++ T H EG + P+ IL D +++++ Sbjct: 289 MYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILC-AQADFTLVLYR 347 Query: 84 EENGR-----------WSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD-GKVSVVEFK 131 + + H ++ P + + S D VSV + + Sbjct: 348 VPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQ 407 Query: 132 ENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDA 191 + G + + + + +G DN ++W+ + Sbjct: 408 AYSEDNAECRSGSYFGHD-VALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPAN 466 Query: 192 QTYVLESTLEGHSDWVRDVAW-------------SPTVLLRSYLASVSQDRTC--IIWTQ 236 +Y + GH + V VA +P ++L S SQDR + Sbjct: 467 NSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPR 526 Query: 237 DNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 ++G + L+ + S +G + A + D V +W Sbjct: 527 QLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVKIWD 572 Score = 70.2 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 49/295 (16%), Positives = 99/295 (33%), Gaps = 43/295 (14%) Query: 14 DAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASC 73 L+ + LA+ + I E T K + + G P+ + G+ L C Sbjct: 25 SVALENGARILASTLGENAIL---TELNTGKRLAEIQGDGEPISTLTITP--SGSHLIVC 79 Query: 74 SYDGKVLIW------KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 S + I+ ++ + + H+ V V A LL ++DG + + Sbjct: 80 SRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPV--VVLAVDRTSTLLATGAADGAIKI 137 Query: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESR---------------- 171 + G + ++ V++ + + + + + K + Sbjct: 138 WDI--IGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASR 195 Query: 172 -KFVTGGADNLVKIWKYNSDAQTYVLE---STLEGHSDWVRDVAWSPTVLLRSYLASVSQ 227 + G D ++I+ T V E H V+ +A+SP L S S+ Sbjct: 196 FRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHA---LLSGSR 252 Query: 228 DRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 D+T +W G W+ T + + L + G + +G + +W Sbjct: 253 DKTMTLWLW--RDGIWQGTPMLRHEL---LESVGFLNEGKWMYSAGTSGVLRIWD 302 >6QX9-5O nrPDB Length = 357 Score = 203 bits (516), Expect = 8e-53, Method: Composition-based stats. Identities = 72/287 (25%), Positives = 117/287 (40%), Gaps = 38/287 (13%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 +++ + H ++ G LA+ D+ I ++ V G+ TL GH G V + + Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDN-YATLKGHSGAVMELHY 117 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGP-LLLVAS 120 G++L S S D V +W E G ++ H++ VNS P GP L+ S Sbjct: 118 NTD--GSMLFSASTDKTVAVWDSETGE--RVKRLKGHTSFVNSC--YPARRGPQLVCTGS 171 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 DG V + + ++ V + ++ S + ++GG DN Sbjct: 172 DDGTVKLWDIRKKAAIQTFQN---TYQVLAVTFN-------------DTSDQIISGGIDN 215 Query: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 +K+W + TY T+ GH+D V ++ S SYL S + D T +W D Sbjct: 216 DIKVWDLRQNKLTY----TMRGHADSVTGLSLSSE---GSYLLSNAMDNTVRVW--DVRP 266 Query: 241 GPWKKTLLK-----EEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 K+ +K F L R SWS G+ +A D V +W Sbjct: 267 FAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWD 313 Score = 117 bits (293), Expect = 5e-27, Method: Composition-based stats. Identities = 48/266 (18%), Positives = 92/266 (34%), Gaps = 54/266 (20%) Query: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 H+ + + + G L + S+DKT+ +++ ET + + L GH V A Sbjct: 103 ATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWD--SETGERVKRLKGHTSFVNSCYPA 160 Query: 63 HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD 122 + ++ + S DG V +W Q ++ V +V + ++ ++ D Sbjct: 161 R-RGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ---NTYQVLAVTF--NDTSDQIISGGID 214 Query: 123 GKVSVVEFKENGTTSPIIIDAHAIGVNSAS------------------------WAP--- 155 + V + ++N T + HA V S +AP Sbjct: 215 NDIKVWDLRQNKLTYTM--RGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKER 272 Query: 156 ----------ATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSD 205 + + + + K G AD V +W D + + L GH+ Sbjct: 273 CVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW----DTTSRRILYKLPGHAG 328 Query: 206 WVRDVAWSPTVLLRSYLASVSQDRTC 231 + +VA+ P + S S D+ Sbjct: 329 SINEVAFHPDE---PIIISASSDKRL 351 >5NNZ-B nrPDB Length = 415 Score = 200 bits (509), Expect = 5e-52, Method: Composition-based stats. Identities = 65/281 (23%), Positives = 111/281 (39%), Gaps = 36/281 (12%) Query: 4 IANAHNELIHDAVLD-YYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 H +++ + YG ++AT S DKT K++ V ET K T GH + + + Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV--ETGKCYHTFRGHTAEIVCLSFN 186 Query: 63 HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD 122 T++A+ S D +W +NG ++ HSA + S+ + + G ++ S D Sbjct: 187 P--QSTLVATGSMDTTAKLWDIQNGE--EVYTLRGHSAEIISLSF--NTSGDRIITGSFD 240 Query: 123 GKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLV 182 V V + + I+ H ++SAS+ + +TG D Sbjct: 241 HTVVVWDADTGRKVN--ILIGHCAEISSASFN-------------WDCSLILTGSMDKTC 285 Query: 183 KIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGP 242 K+W DA +TL GH D + D + +A+ S D T I+ Sbjct: 286 KLW----DATNGKCVATLTGHDDEILDSCFD---YTGKLIATASADGTARIF-----SAA 333 Query: 243 WKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKE 283 +K + K E + + S++ GN L D +W Sbjct: 334 TRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDA 374 Score = 178 bits (452), Expect = 2e-45, Method: Composition-based stats. Identities = 54/276 (19%), Positives = 111/276 (40%), Gaps = 35/276 (12%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H I + +AT S D T K+++++ + + TL GH + + + Sbjct: 175 GHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN--GEEVYTLRGHSAEIISLSFNT--S 230 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 G + + S+D V++W + GR ++ + H A ++S + + L+L S D Sbjct: 231 GDRIITGSFDHTVVVWDADTGR--KVNILIGHCAEISSASF--NWDCSLILTGSMDKTCK 286 Query: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 + + + + H + + + + T AD +I+ Sbjct: 287 LWDATNGKCVA--TLTGHDDEILDSCFD-------------YTGKLIATASADGTARIFS 331 Query: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT 246 A T + LEGH + ++++P ++L + S D+T IW D + G + Sbjct: 332 ----AATRKCIAKLEGHEGEISKISFNPQ---GNHLLTGSSDKTARIW--DAQTGQCLQV 382 Query: 247 LLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 L E D ++ +++ GN++ DN +W+ Sbjct: 383 L---EGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 50/234 (21%), Positives = 92/234 (39%), Gaps = 30/234 (12%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 V H+ I + G R+ T S D T+ +++ +T + ++ L GH + + Sbjct: 212 VYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD--ADTGRKVNILIGHCAEISSASF 269 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 +++ + S D +W NG+ +A H + + G L+ AS+ Sbjct: 270 NWD--CSLILTGSMDKTCKLWDATNGKC--VATLTGHDDEILDSCF--DYTGKLIATASA 323 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 DG + + ++ H ++ S+ P + +TG +D Sbjct: 324 DGTARIFSAATRKCIAK--LEGHEGEISKISFNP-------------QGNHLLTGSSDKT 368 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 +IW DAQT LEGH+D + A+ + + + S+D TC IW Sbjct: 369 ARIW----DAQTGQCLQVLEGHTDEIFSCAF---NYKGNIVITGSKDNTCRIWR 415 Score = 140 bits (353), Expect = 6e-34, Method: Composition-based stats. Identities = 48/270 (17%), Positives = 85/270 (31%), Gaps = 41/270 (15%) Query: 24 LATCSSDKTIKIFEVE---------GETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCS 74 L T S + +K+ T L L H P+ V K G+ + S Sbjct: 54 LLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALN--KSGSCFITGS 111 Query: 75 YDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENG 134 YD +W +G ++ H V ++ + + YG + S D + + Sbjct: 112 YDRTCKLWDTASGE--ELNTLEGHRNVVYAIAFN-NPYGDKIATGSFDKTCKLWSVETGK 168 Query: 135 TTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTY 194 H + S+ P + TG D K+W D Q Sbjct: 169 CY--HTFRGHTAEIVCLSFNPQS-------------TLVATGSMDTTAKLW----DIQNG 209 Query: 195 VLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFP 254 TL GHS + +++ + + S D T ++W D + + Sbjct: 210 EEVYTLRGHSAEIISLSF---NTSGDRIITGSFDHTVVVWDADTGR-----KVNILIGHC 261 Query: 255 DVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 + AS++ +++ D LW Sbjct: 262 AEISSASFNWDCSLILTGSMDKTCKLWDAT 291 Score = 116 bits (291), Expect = 8e-27, Method: Composition-based stats. Identities = 36/129 (27%), Positives = 58/129 (44%), Gaps = 8/129 (6%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 V H++ I D+ DY GK +AT S+D T +IF T K I L GHEG + ++ Sbjct: 295 CVATLTGHDDEILDSCFDYTGKLIATASADGTARIF--SAATRKCIAKLEGHEGEISKIS 352 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 + G L + S D IW + G+ Q+ H+ + S + + G +++ S Sbjct: 353 FNP--QGNHLLTGSSDKTARIWDAQTGQCLQV--LEGHTDEIFSCAF--NYKGNIVITGS 406 Query: 121 SDGKVSVVE 129 D + Sbjct: 407 KDNTCRIWR 415 >6HQA-B nrPDB Length = 722 Score = 192 bits (488), Expect = 1e-49, Method: Composition-based stats. Identities = 66/312 (21%), Positives = 111/312 (35%), Gaps = 58/312 (18%) Query: 9 NELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLI-------------------DTL 49 N + + +A+ D IK++ ++G + + L Sbjct: 390 NNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRL 449 Query: 50 TGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAP 109 GH G V+ VD++ L SCS D V +W + ++ + + HS+SV V+++P Sbjct: 450 VGHSGAVYGVDFSPDN--RYLISCSEDKTVRLWSLDT--YTCLVSYKGHSSSVWDVKFSP 505 Query: 110 HEYGPLLLVASSDGKVSVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEEDGEHNGTK 168 G AS D + P+ I H V+ + P + Sbjct: 506 --MGHYFATASHDQTARLWSCDH---IYPLRIFAGHLNDVDCVEFHPNS----------- 549 Query: 169 ESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQD 228 TG +D ++W D GHS + +A SP +LAS +D Sbjct: 550 --TYLFTGSSDKTARMW----DIARGECVRVFMGHSGAINCLAVSPD---GRWLASAGED 600 Query: 229 RTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGK 288 +W D G K + + ++ ++S G VL +G DN V +W Sbjct: 601 SVVCLW--DISTGRRIKAMRGHGR--SSIYSLAFSREGTVLVSTGADNSVRVWDVKKNTN 656 Query: 289 W-----EPAGEV 295 EP +V Sbjct: 657 SPSAQPEPINDV 668 Score = 154 bits (389), Expect = 4e-38, Method: Composition-based stats. Identities = 45/238 (18%), Positives = 91/238 (38%), Gaps = 31/238 (13%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H+ ++ + L +CS DKT++++ + +T+ + + GH VW V ++ Sbjct: 451 GHSGAVYGVDFSPDNRYLISCSEDKTVRLWSL--DTYTCLVSYKGHSSSVWDVKFSP--M 506 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 G A+ S+D +W ++ + + A H V+ V++ P+ L SSD Sbjct: 507 GHYFATASHDQTARLWSCDH--IYPLRIFAGHLNDVDCVEFHPN--STYLFTGSSDKTAR 562 Query: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 + + + H+ +N + +P + R + G D++V +W Sbjct: 563 MWDIARGECVRVFM--GHSGAINCLAVSP-------------DGRWLASAGEDSVVCLW- 606 Query: 187 YNSDAQTYVLESTLEGH-SDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPW 243 D T + GH + +A+S + L S D + +W Sbjct: 607 ---DISTGRRIKAMRGHGRSSIYSLAFS---REGTVLVSTGADNSVRVWDVKKNTNSP 658 Score = 115 bits (288), Expect = 2e-26, Method: Composition-based stats. Identities = 41/192 (21%), Positives = 71/192 (36%), Gaps = 24/192 (12%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 +V H+ + D G AT S D+T +++ + + GH V V+ Sbjct: 487 CLVSYKGHSSSVWDVKFSPMGHYFATASHDQTARLWSCDHIYP--LRIFAGHLNDVDCVE 544 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 + HP T L + S D +W G + V HS ++N + +P G L A Sbjct: 545 F-HPN-STYLFTGSSDKTARMWDIARGEC--VRVFMGHSGAINCLAVSPD--GRWLASAG 598 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHA-IGVNSASWAPATIEEDGEHNGTKESRKFVTGGAD 179 D V + + + H + S +++ +E V+ GAD Sbjct: 599 EDSVVCLWDISTGRRIKAM--RGHGRSSIYSLAFS-------------REGTVLVSTGAD 643 Query: 180 NLVKIWKYNSDA 191 N V++W + Sbjct: 644 NSVRVWDVKKNT 655 Score = 72.5 bits (176), Expect = 2e-13, Method: Composition-based stats. Identities = 22/106 (20%), Positives = 45/106 (42%), Gaps = 9/106 (8%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGH-EGPVWRV 59 V + H+ I+ + G+ LA+ D + ++++ T + I + GH ++ + Sbjct: 571 CVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDIS--TGRRIKAMRGHGRSSIYSL 628 Query: 60 DWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSV 105 ++ + GT+L S D V +W + S A +N V Sbjct: 629 AFS--REGTVLVSTGADNSVRVWDVKKNTNSPSAQPE----PINDV 668 Score = 48.7 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 17/108 (15%), Positives = 32/108 (29%), Gaps = 19/108 (17%) Query: 195 VLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQD----------------N 238 V T ++ + + ++ + +AS QD +W+ D N Sbjct: 381 VCMYTFHNTNNDLTCLKFNDDSTM---VASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQN 437 Query: 239 EQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLE 286 G K + ++ +S L D V LW + Sbjct: 438 NDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTY 485 Score = 28.6 bits (62), Expect = 3.0, Method: Composition-based stats. Identities = 8/55 (14%), Positives = 17/55 (30%) Query: 227 QDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 QD I + + + L ++ ++A D+ + LW Sbjct: 363 QDSRAKIKLSAAQASLPSVCMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLW 417 >3FM0-A nrPDB Length = 345 Score = 190 bits (481), Expect = 8e-49, Method: Composition-based stats. Identities = 74/283 (26%), Positives = 114/283 (40%), Gaps = 35/283 (12%) Query: 15 AVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTL-TGHEGPVWRVDWAHPKFGTILASC 73 + G LA+C D+ I+I+ EG++ L GH+ V +V W+ G LAS Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSP--CGNYLASA 79 Query: 74 SYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKEN 133 S+D IWK+ + + H V SV WAP G LL S D V V E E Sbjct: 80 SFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPS--GNLLATCSRDKSVWVWEVDEE 137 Query: 134 GTTSPI-IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQ 192 + ++++H V W P+ + D+ VK+++ D Sbjct: 138 DEYECVSVLNSHTQDVKHVVWHPS-------------QELLASASYDDTVKLYREEED-- 182 Query: 193 TYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT-----------QDNEQG 241 +V +TLEGH V +A+ P+ LAS S DRT IW Sbjct: 183 DWVCCATLEGHESTVWSLAFDPS---GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDP 239 Query: 242 PWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 WK ++ +W LA + GD+ + +++E+ Sbjct: 240 SWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQED 282 Score = 157 bits (397), Expect = 4e-39, Method: Composition-based stats. Identities = 70/298 (23%), Positives = 117/298 (39%), Gaps = 38/298 (12%) Query: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 V++ H + G LA+ S D T I++ + + + TL GHE V V WA Sbjct: 55 VLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWA 114 Query: 63 HPKFGTILASCSYDGKVLIWK-EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 G +LA+CS D V +W+ +E + ++V H+ V V W P + LL AS Sbjct: 115 P--SGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQ--ELLASASY 170 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 D V + +E+ ++ H V S ++ P+ ++ + D Sbjct: 171 DDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPS-------------GQRLASCSDDRT 217 Query: 182 VKIWKYNSDAQ-----------TYVLESTLEG-HSDWVRDVAWSPTVLLRSYLASVSQDR 229 V+IW+ ++ TL G HS + D+AW L LA+ D Sbjct: 218 VRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWC---QLTGALATACGDD 274 Query: 230 TCIIWTQDNEQGPWKKTL----LKEEKFPDVLWRASWSL-SGNVLALSGGDNKVTLWK 282 ++ +D P + T + + +W+ +LA D +V WK Sbjct: 275 AIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWK 332 Score = 136 bits (343), Expect = 9e-33, Method: Composition-based stats. Identities = 55/248 (22%), Positives = 93/248 (37%), Gaps = 13/248 (5%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGET-HKLIDTLTGHEGPVWRV 59 V H + G LATCS DK++ ++EV+ E ++ + L H V V Sbjct: 97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHV 156 Query: 60 DWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA 119 W + +LAS SYD V +++EE W A H ++V S+ + P G L Sbjct: 157 VWHPSQ--ELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPS--GQRLASC 212 Query: 120 SSDGKVSVVEFKENGTTSPIIIDAHAIGVNSA-SWAPATIEEDGEHNGTKESRKFVTGGA 178 S D V + G + + + + + + T Sbjct: 213 SDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACG 272 Query: 179 DNLVKIWKYNSDAQ-----TYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII 233 D+ +++++ + ++ + + HS V VAW+P LAS S D Sbjct: 273 DDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPG--LLASCSDDGEVAF 330 Query: 234 WTQDNEQG 241 W +G Sbjct: 331 WKYQRPEG 338 Score = 134 bits (338), Expect = 3e-32, Method: Composition-based stats. Identities = 64/252 (25%), Positives = 103/252 (40%), Gaps = 26/252 (10%) Query: 41 ETHKLIDTLTGHEGP-VWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVH-AVH 98 ++ L+ + H W + W GT+LASC D ++ IW E W +V H Sbjct: 3 DSLVLLGRVPAHPDSRCWFLAWNP--AGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGH 60 Query: 99 SASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATI 158 +V V W+P G L AS D + + ++ ++ H V S +WAP+ Sbjct: 61 QRTVRKVAWSP--CGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPS-- 116 Query: 159 EEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLL 218 T D V +W+ + + + Y S L H+ V+ V W P+ L Sbjct: 117 -----------GNLLATCSRDKSVWVWEVDEEDE-YECVSVLNSHTQDVKHVVWHPSQEL 164 Query: 219 RSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKV 278 LAS S D T ++ ++ + TL E +W ++ SG LA D V Sbjct: 165 ---LASASYDDTVKLYREEEDDWVCCATL---EGHESTVWSLAFDPSGQRLASCSDDRTV 218 Query: 279 TLWKENLEGKWE 290 +W++ L G + Sbjct: 219 RIWRQYLPGNEQ 230 Score = 91.0 bits (224), Expect = 6e-19, Method: Composition-based stats. Identities = 40/130 (30%), Positives = 63/130 (48%), Gaps = 9/130 (6%) Query: 168 KESRKFVTGGADNLVKIWKYNSDAQTYVLESTL-EGHSDWVRDVAWSPTVLLRSYLASVS 226 + G D ++IW D+ ++ +S L EGH VR VAWSP +YLAS S Sbjct: 26 PAGTLLASCGGDRRIRIWGTEGDS--WICKSVLSEGHQRTVRKVAWSP---CGNYLASAS 80 Query: 227 QDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLE 286 D T IW ++ + TL E + + +W+ SGN+LA D V +W+ + E Sbjct: 81 FDATTCIWKKNQDDFECVTTL---EGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEE 137 Query: 287 GKWEPAGEVH 296 ++E ++ Sbjct: 138 DEYECVSVLN 147 >3F3P-A nrPDB Length = 351 Score = 185 bits (468), Expect = 3e-47, Method: Composition-based stats. Identities = 79/357 (22%), Positives = 149/357 (41%), Gaps = 74/357 (20%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGET--HKLIDTLTGHEGPVWR 58 M + H++L+HD V D+YG+ +ATCSSD+ IK+F+++ +T +L D+ H+ + Sbjct: 3 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 62 Query: 59 VDWAHPKFGTILASCSYDGKVLIWKEE-------NGRWSQIAVHAVHSASVNSVQWAPHE 111 +DWA P++G I+AS SYD V +W+E+ RW+++ S+ SV++AP Sbjct: 63 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 122 Query: 112 YGPLLLVASSDGKVSVVEFKENGTTSPIIIDA-----------HAIGVNSASWAPATIEE 160 G L +DG + + + E + + H SW P+ Sbjct: 123 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 182 Query: 161 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV-LLR 219 + K + + I++ D + +V + L GH +R ++W+P++ Sbjct: 183 E----------KLAVSALEQAI-IYQRGKDGKLHV-AAKLPGHKSLIRSISWAPSIGRWY 230 Query: 220 SYLASVSQDRTCIIW-----------------------------------------TQDN 238 +A+ +D I+ + Sbjct: 231 QLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAEL 290 Query: 239 EQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEV 295 + + L + + +W SW+L+G +L+ +G D KV LWK +++ + Sbjct: 291 QSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVI 347 Score = 32.1 bits (71), Expect = 0.26, Method: Composition-based stats. Identities = 7/47 (14%), Positives = 19/47 (40%), Gaps = 1/47 (2%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFE-VEGETHKLIDTLTG 51 + HN + + G L++ D +++++ K + +T Sbjct: 303 DDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITA 349 >5YZG-W nrPDB Length = 579 Score = 183 bits (464), Expect = 8e-47, Method: Composition-based stats. Identities = 62/280 (22%), Positives = 109/280 (38%), Gaps = 31/280 (11%) Query: 6 NAHNELIHDAVLDY-YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 + H + + L G L +CS D IK++EV GE + + T GH V + + Sbjct: 285 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGE-RRCLRTFIGHSKAVRDICFNT- 342 Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGP-LLLVASSDG 123 GT S +YD + +W E G+ + V++ P E L + SD Sbjct: 343 -AGTQFLSAAYDRYLKLWDTETGQC---ISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDK 398 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 K+ + + D H VN+ + E+R+FV+ D ++ Sbjct: 399 KIVQWDIRSGEIVQEY--DRHLGAVNTIVF-------------VDENRRFVSTSDDKSLR 443 Query: 184 IWKYNSDAQ-TYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGP 242 +W+++ Y+ E ++ HS + V SP +LA S D +I+ N Sbjct: 444 VWEWDIPVDFKYIAEPSM--HS--MPAVTLSPN---GKWLACQSMDNQILIFGAQNRFRL 496 Query: 243 WKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 KK + K + +S + + G+ K+ +W Sbjct: 497 NKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWD 536 Score = 76.4 bits (186), Expect = 1e-14, Method: Composition-based stats. Identities = 33/205 (16%), Positives = 68/205 (33%), Gaps = 25/205 (12%) Query: 90 SQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVN 149 QI V + H+ V++V+ P G LLL S D K+ + E H+ V Sbjct: 279 KQIHVWSGHTKGVSAVRLFP-LSGHLLLSCSMDCKIKLWEVYGERRCLR-TFIGHSKAVR 336 Query: 150 SASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRD 209 + +F++ D +K+W D +T S Sbjct: 337 DICFN-------------TAGTQFLSAAYDRYLKLW----DTETGQCISRFTNRKVP-YC 378 Query: 210 VAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVL 269 V ++P ++ + D+ + W D G + + + + + Sbjct: 379 VKFNPDEDKQNLFVAGMSDKKIVQW--DIRSGEIVQEYDRHLGAVNTIVFVDENR---RF 433 Query: 270 ALSGGDNKVTLWKENLEGKWEPAGE 294 + D + +W+ ++ ++ E Sbjct: 434 VSTSDDKSLRVWEWDIPVDFKYIAE 458 Score = 71.8 bits (174), Expect = 3e-13, Method: Composition-based stats. Identities = 40/183 (21%), Positives = 74/183 (40%), Gaps = 24/183 (13%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGET-HKLIDTLTGHEGPVWRVDWAHPKF 66 H ++ V +R + S DK+++++E + K I + H P + Sbjct: 417 HLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLS----PN 472 Query: 67 GTILASCSYDGKVLIWKEENG-RWSQIAVHAVH--SASVNSVQWAPHEYGPLLLVASSDG 123 G LA S D ++LI+ +N R ++ + H + V ++P ++ +G Sbjct: 473 GKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPD--MSYVISGDGNG 530 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 K+++ ++K S AH A W P E+ K +T G D L+K Sbjct: 531 KLNIWDWKTTKLYSRF--KAHDKVCIGAVWHPH------------ETSKVITCGWDGLIK 576 Query: 184 IWK 186 +W Sbjct: 577 LWD 579 >6QDV-o nrPDB Length = 513 Score = 183 bits (463), Expect = 1e-46, Method: Composition-based stats. Identities = 62/280 (22%), Positives = 109/280 (38%), Gaps = 31/280 (11%) Query: 6 NAHNELIHDAVLDY-YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 + H + + L G L +CS D IK++EV GE + + T GH V + + Sbjct: 219 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGE-RRCLRTFIGHSKAVRDICFNT- 276 Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGP-LLLVASSDG 123 GT S +YD + +W E G+ + V++ P E L + SD Sbjct: 277 -AGTQFLSAAYDRYLKLWDTETGQC---ISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDK 332 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 K+ + + D H VN+ + E+R+FV+ D ++ Sbjct: 333 KIVQWDIRSGEIVQEY--DRHLGAVNTIVF-------------VDENRRFVSTSDDKSLR 377 Query: 184 IWKYNSDAQ-TYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGP 242 +W+++ Y+ E ++ HS + V SP +LA S D +I+ N Sbjct: 378 VWEWDIPVDFKYIAEPSM--HS--MPAVTLSPN---GKWLACQSMDNQILIFGAQNRFRL 430 Query: 243 WKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 KK + K + +S + + G+ K+ +W Sbjct: 431 NKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWD 470 Score = 76.0 bits (185), Expect = 2e-14, Method: Composition-based stats. Identities = 33/205 (16%), Positives = 68/205 (33%), Gaps = 25/205 (12%) Query: 90 SQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVN 149 QI V + H+ V++V+ P G LLL S D K+ + E H+ V Sbjct: 213 KQIHVWSGHTKGVSAVRLFP-LSGHLLLSCSMDCKIKLWEVYGERRCLR-TFIGHSKAVR 270 Query: 150 SASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRD 209 + +F++ D +K+W D +T S Sbjct: 271 DICFN-------------TAGTQFLSAAYDRYLKLW----DTETGQCISRFTNRKVP-YC 312 Query: 210 VAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVL 269 V ++P ++ + D+ + W D G + + + + + Sbjct: 313 VKFNPDEDKQNLFVAGMSDKKIVQW--DIRSGEIVQEYDRHLGAVNTIVFVDENR---RF 367 Query: 270 ALSGGDNKVTLWKENLEGKWEPAGE 294 + D + +W+ ++ ++ E Sbjct: 368 VSTSDDKSLRVWEWDIPVDFKYIAE 392 Score = 71.8 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 40/183 (21%), Positives = 74/183 (40%), Gaps = 24/183 (13%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGET-HKLIDTLTGHEGPVWRVDWAHPKF 66 H ++ V +R + S DK+++++E + K I + H P + Sbjct: 351 HLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLS----PN 406 Query: 67 GTILASCSYDGKVLIWKEENG-RWSQIAVHAVH--SASVNSVQWAPHEYGPLLLVASSDG 123 G LA S D ++LI+ +N R ++ + H + V ++P ++ +G Sbjct: 407 GKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPD--MSYVISGDGNG 464 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 K+++ ++K S AH A W P E+ K +T G D L+K Sbjct: 465 KLNIWDWKTTKLYSRF--KAHDKVCIGAVWHPH------------ETSKVITCGWDGLIK 510 Query: 184 IWK 186 +W Sbjct: 511 LWD 513 >6MZM-G nrPDB Length = 800 Score = 178 bits (451), Expect = 2e-45, Method: Composition-based stats. Identities = 54/238 (22%), Positives = 86/238 (36%), Gaps = 35/238 (14%) Query: 47 DTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQ 106 L GH GPV+ ++ + L S S DG V +W + ++ + + H+ V Q Sbjct: 537 KILYGHSGPVYGASFSPDR--NYLLSSSEDGTVRLWSLQT--FTCLVGYKGHNYPVWDTQ 592 Query: 107 WAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEEDGEHN 165 ++P YG + D + P+ I H VN + P + Sbjct: 593 FSP--YGYYFVSGGHDRVARLW---ATDHYQPLRIFAGHLADVNCTRFHPNS-------- 639 Query: 166 GTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASV 225 TG AD V++W D GH + + +SP +LA+ Sbjct: 640 -----NYVATGSADRTVRLW----DVLNGNCVRIFTGHKGPIHSLTFSPN---GRFLATG 687 Query: 226 SQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKE 283 + D ++W D G L + D + +S G +LA DN V LW Sbjct: 688 ATDGRVLLW--DIGHGLMVGEL---KGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA 740 Score = 161 bits (407), Expect = 3e-40, Method: Composition-based stats. Identities = 50/232 (21%), Positives = 91/232 (39%), Gaps = 30/232 (12%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 I H+ ++ A L + S D T++++ + +T + GH PVW ++ Sbjct: 538 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL--QTFTCLVGYKGHNYPVWDTQFSP 595 Query: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 +G S +D +W ++ + + + A H A VN ++ P+ + S+D Sbjct: 596 --YGYYFVSGGHDRVARLWATDHYQ--PLRIFAGHLADVNCTRFHPN--SNYVATGSADR 649 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 V + + I H ++S +++P R TG D V Sbjct: 650 TVRLWDVLNGNCVR--IFTGHKGPIHSLTFSP-------------NGRFLATGATDGRVL 694 Query: 184 IWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 +W D ++ L+GH+D V + +S LAS S D T +W Sbjct: 695 LW----DIGHGLMVGELKGHTDTVCSLRFS---RDGEILASGSMDNTVRLWD 739 Score = 129 bits (324), Expect = 1e-30, Method: Composition-based stats. Identities = 38/205 (18%), Positives = 78/205 (38%), Gaps = 25/205 (12%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 +V HN + D YG + D+ +++ + ++ + GH V Sbjct: 577 CLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDH--YQPLRIFAGHLADVNCTR 634 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 + HP +A+ S D V +W NG + + + H ++S+ ++P+ G L + Sbjct: 635 F-HPN-SNYVATGSADRTVRLWDVLNG--NCVRIFTGHKGPIHSLTFSPN--GRFLATGA 688 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 +DG+V + + + H V S ++ ++ +G DN Sbjct: 689 TDGRVLLWDIGHGLMVGE--LKGHTDTVCSLRFS-------------RDGEILASGSMDN 733 Query: 181 LVKIWKYNSDAQTYVLE--STLEGH 203 V++W + + +T GH Sbjct: 734 TVRLWDAIKAFEDLETDDFTTATGH 758 >6F3T-A nrPDB Length = 608 Score = 177 bits (449), Expect = 4e-45, Method: Composition-based stats. Identities = 58/293 (19%), Positives = 99/293 (33%), Gaps = 64/293 (21%) Query: 21 GKRLATCSSDKTIKIFEVEGETHKL-----------------------------IDTLTG 51 +A +D T++++ V + + + L G Sbjct: 290 SSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYG 349 Query: 52 HEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHE 111 H GPV+ ++ + L S S DG V +W + ++ + + H+ V Q++P Sbjct: 350 HSGPVYGASFSPDR--NYLLSSSEDGTVRLWSLQT--FTCLVGYKGHNYPVWDTQFSP-- 403 Query: 112 YGPLLLVASSDGKVSVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEEDGEHNGTKES 170 YG + D + P+ I H VN + P + Sbjct: 404 YGYYFVSGGHDRVARLW---ATDHYQPLRIFAGHLADVNCTRFHPNS------------- 447 Query: 171 RKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT 230 TG AD V++W D GH + + +SP +LA+ + D Sbjct: 448 NYVATGSADRTVRLW----DVLNGNCVRIFTGHKGPIHSLTFSPN---GRFLATGATDGR 500 Query: 231 CIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKE 283 ++W D G L + D + +S G +LA DN V LW Sbjct: 501 VLLW--DIGHGLMVGEL---KGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA 548 Score = 157 bits (397), Expect = 5e-39, Method: Composition-based stats. Identities = 50/232 (21%), Positives = 91/232 (39%), Gaps = 30/232 (12%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 I H+ ++ A L + S D T++++ + +T + GH PVW ++ Sbjct: 346 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL--QTFTCLVGYKGHNYPVWDTQFSP 403 Query: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 +G S +D +W ++ + + + A H A VN ++ P+ + S+D Sbjct: 404 --YGYYFVSGGHDRVARLWATDHYQ--PLRIFAGHLADVNCTRFHPN--SNYVATGSADR 457 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 V + + I H ++S +++P R TG D V Sbjct: 458 TVRLWDVLNGNCVR--IFTGHKGPIHSLTFSP-------------NGRFLATGATDGRVL 502 Query: 184 IWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 +W D ++ L+GH+D V + +S LAS S D T +W Sbjct: 503 LW----DIGHGLMVGELKGHTDTVCSLRFS---RDGEILASGSMDNTVRLWD 547 Score = 126 bits (316), Expect = 1e-29, Method: Composition-based stats. Identities = 38/205 (18%), Positives = 78/205 (38%), Gaps = 25/205 (12%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 +V HN + D YG + D+ +++ + ++ + GH V Sbjct: 385 CLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDH--YQPLRIFAGHLADVNCTR 442 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 + HP +A+ S D V +W NG + + + H ++S+ ++P+ G L + Sbjct: 443 F-HPN-SNYVATGSADRTVRLWDVLNG--NCVRIFTGHKGPIHSLTFSPN--GRFLATGA 496 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 +DG+V + + + H V S ++ ++ +G DN Sbjct: 497 TDGRVLLWDIGHGLMVGE--LKGHTDTVCSLRFS-------------RDGEILASGSMDN 541 Query: 181 LVKIWKYNSDAQTYVLE--STLEGH 203 V++W + + +T GH Sbjct: 542 TVRLWDAIKAFEDLETDDFTTATGH 566 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 23/115 (20%), Positives = 34/115 (29%), Gaps = 23/115 (20%) Query: 167 TKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVS 226 T +S G AD+ V++W V ++ D++ S Sbjct: 287 TDDSSLIAGGFADSTVRVWSVTPKKLRSVKQA---------SDLSLIDKE---------S 328 Query: 227 QDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 D I L ++ AS+S N L S D V LW Sbjct: 329 DDVLERI-----MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLW 378 >5FL8-q nrPDB Length = 515 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 70/308 (22%), Positives = 110/308 (35%), Gaps = 50/308 (16%) Query: 5 ANAHNELIHDAVLDY-------YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVW 57 H++ I + RLA+ S D TIKI++ + T++GH V Sbjct: 225 LRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQY--TMSGHTNSVS 282 Query: 58 RVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLL 117 V W +L S S+D V +W N + I + H+ VN + + + Sbjct: 283 CVKWGGQ---GLLYSGSHDRTVRVWDI-NSQGRCINILKSHAHWVNHLSLSTDYALRIGA 338 Query: 118 VASSDGKVSVVE-------------FKENGTTSPIIIDAHAIGVNSASWAPATIEE---- 160 + K S E K+NG + +++ A + W P + Sbjct: 339 FDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTA-SDDYTMFLWNPLKSTKPIAR 397 Query: 161 -------DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWS 213 + + R V+ DN +K+W D + ST GH V VAWS Sbjct: 398 MTGHQKLVNHVAFSPDGRYIVSASFDNSIKLW----DGRDGKFISTFRGHVASVYQVAWS 453 Query: 214 PTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSG 273 L L S S+D T +W +K + D ++ WS+ G + G Sbjct: 454 SDCRL---LVSCSKDTTLKVWDVR-----TRKLSVDLPGHKDEVYTVDWSVDGKRVCSGG 505 Query: 274 GDNKVTLW 281 D V LW Sbjct: 506 KDKMVRLW 513 Score = 165 bits (417), Expect = 2e-41, Method: Composition-based stats. Identities = 72/331 (21%), Positives = 114/331 (34%), Gaps = 56/331 (16%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 H + G+ +AT S D TI++++ + L D L GH + + W Sbjct: 181 TLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQC-LGDALRGHSKWITSLSWEP 239 Query: 64 -----PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 118 P LAS S DG + IW + + H+ SV+ V+W LL Sbjct: 240 IHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQ--YTMSGHTNSVSCVKW---GGQGLLYS 294 Query: 119 ASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWA----------------PATIEEDG 162 S D V V + G I+ +HA VN S + P+T EE Sbjct: 295 GSHDRTVRVWDINSQGRC-INILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQ 353 Query: 163 EHN----------GTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAW 212 + VT D + +W ++ + + GH V VA+ Sbjct: 354 KKALENYEKICKKNGNSEEMMVTASDDYTMFLWN---PLKSTKPIARMTGHQKLVNHVAF 410 Query: 213 SPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALS 272 SP Y+ S S D + +W D G + T +++ +WS +L Sbjct: 411 SPD---GRYIVSASFDNSIKLW--DGRDGKFISTFR---GHVASVYQVAWSSDCRLLVSC 462 Query: 273 GGDNKVTLWK-------ENLEGKWEPAGEVH 296 D + +W +L G + V Sbjct: 463 SKDTTLKVWDVRTRKLSVDLPGHKDEVYTVD 493 Score = 156 bits (395), Expect = 8e-39, Method: Composition-based stats. Identities = 56/320 (17%), Positives = 102/320 (31%), Gaps = 70/320 (21%) Query: 5 ANAHNELIHDAVLDYY-GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 H I + + R+ T + D T +I++ +T + TL GH V V W+ Sbjct: 139 IAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDC--DTQTPMHTLKGHYNWVLCVSWSP 196 Query: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHE-----YGPLLLV 118 G ++A+ S D + +W ++G+ HS + S+ W P P L Sbjct: 197 D--GEVIATGSMDNTIRLWDPKSGQCLG-DALRGHSKWITSLSWEPIHLVKPGSKPRLAS 253 Query: 119 ASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGA 178 +S DG + + + + H V+ W +G Sbjct: 254 SSKDGTIKIWDT--VSRVCQYTMSGHTNSVSCVKW--------------GGQGLLYSGSH 297 Query: 179 DNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSP------------------------ 214 D V++W NS + L+ H+ WV ++ S Sbjct: 298 DRTVRVWDINS---QGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQK 354 Query: 215 ------------TVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASW 262 + + S D T +W P + + ++ ++ Sbjct: 355 KALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKP----IARMTGHQKLVNHVAF 410 Query: 263 SLSGNVLALSGGDNKVTLWK 282 S G + + DN + LW Sbjct: 411 SPDGRYIVSASFDNSIKLWD 430 Score = 119 bits (299), Expect = 1e-27, Method: Composition-based stats. Identities = 48/272 (17%), Positives = 89/272 (32%), Gaps = 64/272 (23%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 + H + G L + S D+T++++++ + + I+ L H V + Sbjct: 270 CQYTMSGHTNSVSCVKWGGQG-LLYSGSHDRTVRVWDINSQ-GRCINILKSHAHWVNHLS 327 Query: 61 WAHP-------------------------------------KFGTILASCSYDGKVLIWK 83 + ++ + S D + +W Sbjct: 328 LSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWN 387 Query: 84 EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDA 143 IA H VN V ++P G ++ AS D + + + ++ S Sbjct: 388 -PLKSTKPIARMTGHQKLVNHVAFSPD--GRYIVSASFDNSIKLWDGRDGKFISTF--RG 442 Query: 144 HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGH 203 H V +W+ + R V+ D +K+W D +T L L GH Sbjct: 443 HVASVYQVAWS-------------SDCRLLVSCSKDTTLKVW----DVRTRKLSVDLPGH 485 Query: 204 SDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 D V V WS + + S +D+ +WT Sbjct: 486 KDEVYTVDWS---VDGKRVCSGGKDKMVRLWT 514 Score = 85.6 bits (210), Expect = 2e-17, Method: Composition-based stats. Identities = 46/211 (21%), Positives = 71/211 (33%), Gaps = 38/211 (18%) Query: 87 GRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA---SSDGKVSVVEFK-----ENGTTSP 138 +S S V ++ + Y L+ + D + + + T S Sbjct: 77 YTFSCTIQGKKASDPVKTIDITDNLYSSLIKPGYNSTEDQITLLYTPRAVFKVKPVTRSS 136 Query: 139 IIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLES 198 I H + +++AP T + VTG DN +IW D T Sbjct: 137 SAIAGHGSTILCSAFAPHTSS------------RMVTGAGDNTARIW----DCDTQTPMH 180 Query: 199 TLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLW 258 TL+GH +WV V+WSP +A+ S D T +W + Q + Sbjct: 181 TLKGHYNWVLCVSWSPD---GEVIATGSMDNTIRLWDPKSGQ----CLGDALRGHSKWIT 233 Query: 259 RASWSL-------SGNVLALSGGDNKVTLWK 282 SW S LA S D + +W Sbjct: 234 SLSWEPIHLVKPGSKPRLASSSKDGTIKIWD 264 >4V6W-Ag nrPDB Length = 318 Score = 170 bits (430), Expect = 7e-43, Method: Composition-based stats. Identities = 59/249 (23%), Positives = 97/249 (38%), Gaps = 31/249 (12%) Query: 40 GETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIW----KEENGRWSQIAVH 95 ET +L TL GH G V ++ +PK + S S D +++W E+ Sbjct: 2 SETLQLRGTLIGHNGWVTQIA-TNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRL 60 Query: 96 AVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAP 155 HS ++ V + G L S D + + + TT + H V S +++ Sbjct: 61 YGHSHFISDVVLSSD--GNYALSGSWDQTLRLWDLAAGKTTRRF--EGHTKDVLSVAFS- 115 Query: 156 ATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPT 215 ++R+ V+G D +K+W ++ + + E +GH+DWV V +SP Sbjct: 116 ------------ADNRQIVSGSRDKTIKLWNTLAECKFTIQE---DGHTDWVSCVRFSPN 160 Query: 216 VLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGD 275 + S DRT +W N K L + S G++ G D Sbjct: 161 -HSNPIIVSCGWDRTVKVWNLANC-----KLKNNHHGHNGYLNTVTVSPDGSLCTSGGKD 214 Query: 276 NKVTLWKEN 284 +K LW N Sbjct: 215 SKALLWDLN 223 Score = 139 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 53/286 (18%), Positives = 102/286 (35%), Gaps = 33/286 (11%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H+ I D VL G + S D+T++++++ K GH V V ++ Sbjct: 62 GHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAA--GKTTRRFEGHTKDVLSVAFSADN- 118 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 + S S D + +W H+ V+ V+++P+ P+++ D V Sbjct: 119 -RQIVSGSRDKTIKLWNT-LAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVK 176 Query: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 V + H +N+ + +P + +GG D+ +W Sbjct: 177 VWNLANCKLKNNH--HGHNGYLNTVTVSP-------------DGSLCTSGGKDSKALLWD 221 Query: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ--GPWK 244 N Y LE H+D + + +SP Y V+ + IW ++ + Sbjct: 222 LNDGKNLYTLE-----HNDIINALCFSPN----RYWLCVAYGPSIKIWDLACKKTVEELR 272 Query: 245 KTLLKEEKFPD--VLWRASWSLSGNVLALSGGDNKVTLWKENLEGK 288 ++ D +WS G L DN + +W+ ++ Sbjct: 273 PEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQVSVSAH 318 Score = 110 bits (274), Expect = 8e-25, Method: Composition-based stats. Identities = 45/234 (19%), Positives = 81/234 (34%), Gaps = 30/234 (12%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 H + + +++ + S DKTIK++ E I GH V V ++ Sbjct: 103 EGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTLAECKFTIQE-DGHTDWVSCVRFSPNH 161 Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 I+ SC +D V +W N H H+ +N+V +P G L D K Sbjct: 162 SNPIIVSCGWDRTVKVWNLAN--CKLKNNHHGHNGYLNTVTVSPD--GSLCTSGGKDSKA 217 Query: 126 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 + + + + H +N+ ++P +R ++ +KIW Sbjct: 218 LLWDLNDGKNLYTL---EHNDIINALCFSP--------------NRYWLCVAYGPSIKIW 260 Query: 186 KYN-----SDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 + + V+ T + +AWS L + D T +W Sbjct: 261 DLACKKTVEELRPEVVSPTSKADQPQCLSLAWS---TDGQTLFAGYSDNTIRVW 311 >5M25-A nrPDB Length = 434 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 54/240 (22%), Positives = 100/240 (41%), Gaps = 28/240 (11%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 + H+ + + + + S D++++I++V+ T K + TL H PV V Sbjct: 221 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK--TGKCLKTLPAHSDPVSAVH 278 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 + G+++ S SYDG IW +G+ + + + V+ V+++P+ G +L A+ Sbjct: 279 FNRD--GSLIVSSSYDGLCRIWDTASGQCLKTLI-DDDNPPVSFVKFSPN--GKYILAAT 333 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 D + + ++ + H + + V+G DN Sbjct: 334 LDNTLKLWDYSKGKCLKTY--TGHKNEKYCIF----------ANFSVTGGKWIVSGSEDN 381 Query: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVS--QDRTCIIWTQDN 238 LV IW + QT + L+GH+D V A PT +AS + D+T +W D Sbjct: 382 LVYIW----NLQTKEIVQKLQGHTDVVISTACHPTEN---IIASAALENDKTIKLWKSDC 434 Score = 166 bits (421), Expect = 8e-42, Method: Composition-based stats. Identities = 64/288 (22%), Positives = 111/288 (38%), Gaps = 37/288 (12%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 H + + G+ LA+ S+DK IKI+ + T++GH+ + V W+ Sbjct: 140 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGISDVAWSS 197 Query: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 +L S S D + IW +G+ + HS V + P L++ S D Sbjct: 198 D--SNLLVSASDDKTLKIWDVSSGKCLK--TLKGHSNYVFCCNFNPQ--SNLIVSGSFDE 251 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 V + + K + AH+ V++ + ++ V+ D L + Sbjct: 252 SVRIWDVKTGKCLK--TLPAHSDPVSAVHFN-------------RDGSLIVSSSYDGLCR 296 Query: 184 IWKYNSDAQTYVLESTLEGHSD-WVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGP 242 IW D + TL + V V +SP Y+ + + D T +W D +G Sbjct: 297 IW----DTASGQCLKTLIDDDNPPVSFVKFSPN---GKYILAATLDNTLKLW--DYSKGK 347 Query: 243 WKKTLLKEEKFPDVLWRASWSLSGNV-LALSGGDNKVTLWKENLEGKW 289 KT + A++S++G + DN V +W NL+ K Sbjct: 348 CLKTYTGHKN-EKYCIFANFSVTGGKWIVSGSEDNLVYIW--NLQTKE 392 Score = 99.9 bits (247), Expect = 1e-21, Method: Composition-based stats. Identities = 41/166 (24%), Positives = 62/166 (37%), Gaps = 32/166 (19%) Query: 138 PIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLE 197 + H V+S ++P + AD L+KIW A E Sbjct: 138 KFTLAGHTKAVSSVKFSP-------------NGEWLASSSADKLIKIW----GAYDGKFE 180 Query: 198 STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVL 257 T+ GH + DVAWS L L S S D+T IW D G KTL + + + Sbjct: 181 KTISGHKLGISDVAWSSDSNL---LVSASDDKTLKIW--DVSSGKCLKTL---KGHSNYV 232 Query: 258 WRASWSLSGNVLALSGGDNKVTLWK-------ENLEGKWEPAGEVH 296 + +++ N++ D V +W + L +P VH Sbjct: 233 FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH 278 >5GAN-H nrPDB Length = 465 Score = 167 bits (423), Expect = 5e-42, Method: Composition-based stats. Identities = 50/229 (21%), Positives = 97/229 (42%), Gaps = 26/229 (11%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H I D GK + + S D T ++++ TH+ + GH+ V+ + + Sbjct: 263 GHERRISDVKYHPSGKFIGSASHDMTWRLWD--ASTHQELLLQEGHDKGVFSLSFQCD-- 318 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 G+++ S D ++W +G S++ A HS + +V W+P+ Y + DG ++ Sbjct: 319 GSLVCSGGMDSLSMLWDIRSG--SKVMTLAGHSKPIYTVAWSPNGYQ--VATGGGDGIIN 374 Query: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 V + ++ I AH V ++ +K V+ G DNL+ ++ Sbjct: 375 VWDIRKRDEGQLNQILAHRNIVTQVRFS-----------KEDGGKKLVSCGYDNLINVYS 423 Query: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 + T++ +L GH+D + + S +L S DR+ +W Sbjct: 424 SD----TWLKMGSLAGHTDKIISLDISNN---SHFLVSGGWDRSIKLWN 465 Score = 127 bits (318), Expect = 7e-30, Method: Composition-based stats. Identities = 50/280 (17%), Positives = 98/280 (35%), Gaps = 32/280 (11%) Query: 5 ANAHNELIHDAVLDY-YGKRLATCSSDKTIKIFEVEGE--THKLIDTLTGHEGPVWRVDW 61 ++H I ++ +C+ D IK F+ E +L+ L GHE + V + Sbjct: 214 LDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKY 273 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 HP G + S S+D +W ++ + H V S+ + G L+ Sbjct: 274 -HP-SGKFIGSASHDMTWRLWDAST--HQELLLQEGHDKGVFSLSFQCD--GSLVCSGGM 327 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 D + + + + + + H+ + + +W+P + TGG D + Sbjct: 328 DSLSMLWDIRSG--SKVMTLAGHSKPIYTVAWSP-------------NGYQVATGGGDGI 372 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQG 241 + +W + + + H + V V +S L S D +++ D Sbjct: 373 INVWDIRK--RDEGQLNQILAHRNIVTQVRFS-KEDGGKKLVSCGYDNLINVYSSD---- 425 Query: 242 PWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 + D + S + + L G D + LW Sbjct: 426 -TWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLW 464 Score = 94.5 bits (233), Expect = 5e-20, Method: Composition-based stats. Identities = 23/128 (17%), Positives = 54/128 (42%), Gaps = 4/128 (3%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 V+ H++ I+ G ++AT D I ++++ ++ + H V +V + Sbjct: 342 VMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRF 401 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 + G L SC YD + ++ + W ++ A H+ + S+ + + + L+ Sbjct: 402 SKEDGGKKLVSCGYDNLINVYSSDT--WLKMGSLAGHTDKIISLDISNNSH--FLVSGGW 457 Query: 122 DGKVSVVE 129 D + + Sbjct: 458 DRSIKLWN 465 Score = 93.3 bits (230), Expect = 1e-19, Method: Composition-based stats. Identities = 31/185 (16%), Positives = 69/185 (37%), Gaps = 19/185 (10%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 +++ H++ + G + + D ++++ + + TL GH P++ V W Sbjct: 300 LLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSK--VMTLAGHSKPIYTVAW 357 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 + G +A+ DG + +W Q+ H V V+++ + G L+ Sbjct: 358 SPN--GYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGY 415 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 D ++V ++ + G + + + S V+GG D Sbjct: 416 DNLINVY------SSDTWLKMGSLAGHTD---------KIISLDISNNSHFLVSGGWDRS 460 Query: 182 VKIWK 186 +K+W Sbjct: 461 IKLWN 465 Score = 88.7 bits (218), Expect = 3e-18, Method: Composition-based stats. Identities = 37/232 (15%), Positives = 81/232 (34%), Gaps = 31/232 (13%) Query: 53 EGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEY 112 P+ V + ++A+ S+ G + + + + H + ++ W P Sbjct: 175 TKPISAVSLSTDDM--VVATGSWAGDLQVLNSQTLQ-PLTQKLDSHVGKIGAIDWHPDSN 231 Query: 113 GPLLLVASSDGKVSVVEFKENGTTSPII--IDAHAIGVNSASWAPATIEEDGEHNGTKES 170 ++ + DG + ++ ++ + H ++ + P+ Sbjct: 232 NQMI-SCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPS-------------G 277 Query: 171 RKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT 230 + + D ++W DA T+ EGH V +++ S + S D Sbjct: 278 KFIGSASHDMTWRLW----DASTHQELLLQEGHDKGVFSLSFQCD---GSLVCSGGMDSL 330 Query: 231 CIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 ++W D G TL ++ +WS +G +A GGD + +W Sbjct: 331 SMLW--DIRSGSKVMTL---AGHSKPIYTVAWSPNGYQVATGGGDGIINVWD 377 Score = 51.7 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 20/115 (17%), Positives = 37/115 (32%), Gaps = 9/115 (7%) Query: 176 GGADNLVKIWKYNSDAQTYV------LESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDR 229 D +V + D Q L L+ H + + W P + + S ++D Sbjct: 184 STDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQ--MISCAEDG 241 Query: 230 TCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 + NE+G + L + + SG + + D LW + Sbjct: 242 LIKNFQYSNEEGGLRL-LGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDAS 295 >3DM0-A nrPDB Length = 694 Score = 167 bits (422), Expect = 6e-42, Method: Composition-based stats. Identities = 55/241 (22%), Positives = 93/241 (38%), Gaps = 28/241 (11%) Query: 45 LIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK-EENGRWSQIAV--HAVHSAS 101 L T+ H V + I+ S S D +++WK ++ + +A HS Sbjct: 374 LKGTMRAHTDMVTAIATPIDNA-DIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHF 432 Query: 102 VNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEED 161 V V + G L S DG++ + + +T + H V S +++ Sbjct: 433 VEDVVLSSD--GQFALSGSWDGELRLWDLAAGVSTRRFV--GHTKDVLSVAFS------- 481 Query: 162 GEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSY 221 ++R+ V+ D +K+W + + Y + EGH DWV V +SP L + Sbjct: 482 ------LDNRQIVSASRDRTIKLWNTLGECK-YTISEGGEGHRDWVSCVRFSPNTL-QPT 533 Query: 222 LASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 + S S D+T +W N K + + S G++ A G D V LW Sbjct: 534 IVSASWDKTVKVWNLSNC-----KLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLW 588 Query: 282 K 282 Sbjct: 589 D 589 Score = 145 bits (365), Expect = 2e-35, Method: Composition-based stats. Identities = 48/292 (16%), Positives = 100/292 (34%), Gaps = 43/292 (14%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 H+ + D VL G+ + S D ++++++ GH V V ++ Sbjct: 426 LTGHSHFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVST--RRFVGHTKDVLSVAFSLD 483 Query: 65 KFGTILASCSYDGKVLIWKEENG-RWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 + S S D + +W +++ H V+ V+++P+ P ++ AS D Sbjct: 484 N--RQIVSASRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDK 541 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 V V S + H V++ + +P + +GG D +V Sbjct: 542 TVKVWNLSNCKLRS--TLAGHTGYVSTVAVSP-------------DGSLCASGGKDGVVL 586 Query: 184 IWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNE---- 239 +W + Y LE+ + + + +SP Y + + IW +++ Sbjct: 587 LWDLAEGKKLYSLEA-----NSVIHALCFSPN----RYWLCAATEHGIKIWDLESKSIVE 637 Query: 240 ----------QGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 + ++ +WS G+ L D + +W Sbjct: 638 DLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLFSGYTDGVIRVW 689 Score = 129 bits (324), Expect = 1e-30, Method: Composition-based stats. Identities = 60/285 (21%), Positives = 108/285 (37%), Gaps = 38/285 (13%) Query: 4 IANAHNELIHDAV--LDYYGKRLATCSSDKTIKIFEVEGETHKL---IDTLTGHEGPVWR 58 AH +++ +D + + S DK+I ++++ + LTGH V Sbjct: 377 TMRAHTDMVTAIATPID-NADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVED 435 Query: 59 VDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 118 V + G S S+DG++ +W G ++ H+ V SV ++ ++ Sbjct: 436 VVLSSD--GQFALSGSWDGELRLWDLAAGVSTRR--FVGHTKDVLSVAFSLD--NRQIVS 489 Query: 119 ASSDGKVSVVE-FKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGG 177 AS D + + E T + H V+ ++P T++ V+ Sbjct: 490 ASRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPT-----------IVSAS 538 Query: 178 ADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQD 237 D VK+W + L STL GH+ +V VA SP S AS +D ++W Sbjct: 539 WDKTVKVWNLS----NCKLRSTLAGHTGYVSTVAVSPD---GSLCASGGKDGVVLLWDL- 590 Query: 238 NEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 +G +L V+ +S + L + + +W Sbjct: 591 -AEGKKLYSLEAN----SVIHALCFSPNRYWLCAATEHG-IKIWD 629 Score = 84.5 bits (207), Expect = 6e-17, Method: Composition-based stats. Identities = 36/193 (18%), Positives = 71/193 (36%), Gaps = 30/193 (15%) Query: 98 HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTS---PIIIDAHAIGVNSASWA 154 H+ V ++ P + +++ AS D + + + ++ + H+ V + Sbjct: 381 HTDMVTAIA-TPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLS 439 Query: 155 PATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSP 214 + + ++G D +++W D V GH+ V VA+S Sbjct: 440 -------------SDGQFALSGSWDGELRLW----DLAAGVSTRRFVGHTKDVLSVAFS- 481 Query: 215 TVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLL-KEEKFPDVLWRASWSLSG--NVLAL 271 L + S S+DRT +W N G K T+ E D + +S + + Sbjct: 482 --LDNRQIVSASRDRTIKLW---NTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVS 536 Query: 272 SGGDNKVTLWKEN 284 + D V +W + Sbjct: 537 ASWDKTVKVWNLS 549 Score = 57.1 bits (136), Expect = 8e-09, Method: Composition-based stats. Identities = 15/143 (10%), Positives = 38/143 (26%), Gaps = 21/143 (14%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 + H + + G A+ D + ++++ K + +L + + Sbjct: 553 LRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAE--GKKLYSLEA-NSVIHALC 609 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENG---------------RWSQIAVHAVHSASVNSV 105 ++ + + + IW E+ + A + Sbjct: 610 FSP---NRYWLCAATEHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCT 666 Query: 106 QWAPHEYGPLLLVASSDGKVSVV 128 G L +DG + V Sbjct: 667 SLNWSADGSTLFSGYTDGVIRVW 689 Score = 52.9 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 18/88 (20%), Positives = 34/88 (38%), Gaps = 2/88 (2%) Query: 195 VLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFP 254 VL+ T+ H+D V +A +P + S S+D++ I+W + + + Sbjct: 373 VLKGTMRAHTDMVTAIA-TPIDN-ADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHS 430 Query: 255 DVLWRASWSLSGNVLALSGGDNKVTLWK 282 + S G D ++ LW Sbjct: 431 HFVEDVVLSSDGQFALSGSWDGELRLWD 458 >6G51-g nrPDB Length = 317 Score = 166 bits (421), Expect = 7e-42, Method: Composition-based stats. Identities = 59/247 (23%), Positives = 94/247 (38%), Gaps = 30/247 (12%) Query: 41 ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK---EENGRWSQIAVHAV 97 E L TL GH G V ++ P+F ++ S S D +++WK +E Sbjct: 3 EQMTLRGTLKGHNGWVTQIA-TTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 Query: 98 HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPAT 157 HS V+ V + G L S DG + + + TT + H V S +++ Sbjct: 62 HSHFVSDVVISSD--GQFALSGSWDGTLRLWDLTTGTTTRRFV--GHTKDVLSVAFS--- 114 Query: 158 IEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVL 217 ++R+ V+G D +K+W + V + E HS+WV V +SP Sbjct: 115 ----------SDNRQIVSGSRDKTIKLWNTLGVCKYTVQD---ESHSEWVSCVRFSPNS- 160 Query: 218 LRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNK 277 + S D+ +W N K L + S G++ A G D + Sbjct: 161 SNPIIVSCGWDKLVKVWNLANC-----KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQ 215 Query: 278 VTLWKEN 284 LW N Sbjct: 216 AMLWDLN 222 Score = 138 bits (346), Expect = 4e-33, Method: Composition-based stats. Identities = 52/285 (18%), Positives = 99/285 (34%), Gaps = 33/285 (11%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 H+ + D V+ G+ + S D T++++++ T GH V V ++ Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLT--TGTTTRRFVGHTKDVLSVAFSSD 116 Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 + S S D + +W G HS V+ V+++P+ P+++ D Sbjct: 117 N--RQIVSGSRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL 173 Query: 125 VSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 V V + I H +N+ + +P + +GG D + Sbjct: 174 VKVWNLANCKLKTNHI--GHTGYLNTVTVSP-------------DGSLCASGGKDGQAML 218 Query: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNE----Q 240 W N Y L+ D + + +SP Y + + IW + + + Sbjct: 219 WDLNEGKHLYTLDGG-----DIINALCFSPN----RYWLCAATGPSIKIWDLEGKIIVDE 269 Query: 241 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENL 285 + + P +WS G L DN V +W+ + Sbjct: 270 LKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 Score = 116 bits (291), Expect = 9e-27, Method: Composition-based stats. Identities = 55/283 (19%), Positives = 103/283 (36%), Gaps = 36/283 (12%) Query: 4 IANAHNELIHDAVLDY-YGKRLATCSSDKTIKIFEV---EGETHKLIDTLTGHEGPVWRV 59 HN + + + + S DKTI ++++ E L GH V V Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 Query: 60 DWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA 119 + G S S+DG + +W G ++ H+ V SV ++ ++ Sbjct: 70 VISSD--GQFALSGSWDGTLRLWDLTTGTTTRR--FVGHTKDVLSVAFSSD--NRQIVSG 123 Query: 120 SSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGAD 179 S D + + + ++H+ V+ ++P + V+ G D Sbjct: 124 SRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPI-----------IVSCGWD 171 Query: 180 NLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNE 239 LVK+W + L++ GH+ ++ V SP S AS +D ++W Sbjct: 172 KLVKVW----NLANCKLKTNHIGHTGYLNTVTVSPD---GSLCASGGKDGQAMLWDL--N 222 Query: 240 QGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 +G TL D++ +S + L + G + +W Sbjct: 223 EGKHLYTLDGG----DIINALCFSPNRYWLCAATG-PSIKIWD 260 Score = 97.6 bits (241), Expect = 6e-21, Method: Composition-based stats. Identities = 37/223 (16%), Positives = 70/223 (31%), Gaps = 45/223 (20%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H + + +++ + S DKTIK++ G K H V V ++ Sbjct: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLG-VCKYTVQDESHSEWVSCVRFSPNSS 161 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 I+ SC +D V +W N H H+ +N+V +P G L DG+ Sbjct: 162 NPIIVSCGWDKLVKVWNLAN--CKLKTNHIGHTGYLNTVTVSPD--GSLCASGGKDGQAM 217 Query: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATI---------------------------- 158 + + E + +N+ ++P Sbjct: 218 LWDLNEGKHLYTL---DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEV 274 Query: 159 ---------EEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQ 192 + + + + G DNLV++W+ + Sbjct: 275 ISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 Score = 55.2 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 20/94 (21%), Positives = 34/94 (36%), Gaps = 2/94 (2%) Query: 191 AQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKE 250 + L TL+GH+ WV +A +P + S S+D+T I+W ++ + Sbjct: 2 TEQMTLRGTLKGHNGWVTQIATTPQFP--DMILSASRDKTIIMWKLTRDETNYGIPQRAL 59 Query: 251 EKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 + S G D + LW Sbjct: 60 RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLT 93 >5Y1U-A nrPDB Length = 456 Score = 166 bits (421), Expect = 8e-42, Method: Composition-based stats. Identities = 69/317 (21%), Positives = 113/317 (35%), Gaps = 48/317 (15%) Query: 8 HNELIHDAVLDYYGK-RLATCSSDKTIKIFEVE------GETHKLID--TLTGHEGPVWR 58 H ++ A +AT + + +F+ + + L GH+ + Sbjct: 154 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 213 Query: 59 VDWAHPKFGTILASCSYDGKVLIWKE-----ENGRWSQIAVHAVHSASVNSVQWAPHEYG 113 + W +P L S S D + +W E + H+A V V W + Sbjct: 214 LSW-NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHL-LHE 271 Query: 114 PLLLVASSDGKVSVVEFKENGTTSP-IIIDAHAIGVNSASWAPATIEEDGEHNGTKESRK 172 L + D K+ + + + N T+ P +DAH VN S+ P + Sbjct: 272 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI------------ 319 Query: 173 FVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 232 TG AD V +W + + + E H D + V WSP + LAS DR Sbjct: 320 LATGSADKTVALWDLRN---LKLKLHSFESHKDEIFQVQWSPHN--ETILASSGTDRRLN 374 Query: 233 IWTQ----------DNEQGPWKKTLLKEEKFPDVLWRASWSLSGN-VLALSGGDNKVTLW 281 +W D E GP + L + SW+ + V+ DN + +W Sbjct: 375 VWDLSKIGEEQSPEDAEDGPPEL-LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 433 Query: 282 K--ENLEGKWEPAGEVH 296 + EN+ +P G V Sbjct: 434 QMAENIYNDEDPEGSVD 450 Score = 104 bits (258), Expect = 6e-23, Method: Composition-based stats. Identities = 36/147 (24%), Positives = 67/147 (45%), Gaps = 16/147 (10%) Query: 5 ANAHNELIHDAVLDYYGKR-LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 +AH ++ + Y + LAT S+DKT+ ++++ KL + H+ +++V W+ Sbjct: 300 VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWS- 357 Query: 64 PKFGTILASCSYDGKVLIWKE------------ENGRWSQIAVHAVHSASVNSVQWAPHE 111 P TILAS D ++ +W E+G + +H H+A ++ W P+E Sbjct: 358 PHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE 417 Query: 112 YGPLLLVASSDGKVSVVEFKENGTTSP 138 ++ S D + V + EN Sbjct: 418 P-WVICSVSEDNIMQVWQMAENIYNDE 443 >6QX9-4B nrPDB Length = 522 Score = 165 bits (417), Expect = 2e-41, Method: Composition-based stats. Identities = 60/281 (21%), Positives = 99/281 (35%), Gaps = 38/281 (13%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW----- 61 + I K LAT K++ V L+ TL GH V + + Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSV--PDCNLLHTLRGHNTNVGAIVFHPKST 286 Query: 62 -AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 + LASC+ DG V +W ++ +A H+ V V W P G L Sbjct: 287 VSLDPKDVNLASCAADGSVKLWSLDSDE--PVADIEGHTVRVARVMWHPS--GRFLGTTC 342 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 D + + + + + H++GV ++ ++ TGG D Sbjct: 343 YDRSWRLWDLEA--QEEILHQEGHSMGVYDIAFH-------------QDGSLAGTGGLDA 387 Query: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 ++W D +T LEGH + + +SP ++A+ S D TC +W Q Sbjct: 388 FGRVW----DLRTGRCIMFLEGHLKEIYGINFSPN---GYHIATGSGDNTCKVWDL--RQ 438 Query: 241 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 T+ + + + GN L DN +W Sbjct: 439 RRCVYTIPAHQNLVTGVKFEP--IHGNFLLTGAYDNTAKIW 477 Score = 139 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 59/289 (20%), Positives = 103/289 (35%), Gaps = 42/289 (14%) Query: 1 MVVIANAHNELI--------HDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGH 52 ++ HN + LD LA+C++D ++K++ ++ + + + + GH Sbjct: 265 LLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSD--EPVADIEGH 322 Query: 53 EGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEY 112 V RV W HP G L + YD +W E +I HS V + + H+ Sbjct: 323 TVRVARVMW-HP-SGRFLGTTCYDRSWRLWDLEAQE--EILHQEGHSMGVYDIAF--HQD 376 Query: 113 GPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRK 172 G L D V + + + ++ H + +++P Sbjct: 377 GSLAGTGGLDAFGRVWDLRTGRCI--MFLEGHLKEIYGINFSP-------------NGYH 421 Query: 173 FVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 232 TG DN K+W D + T+ H + V V + P + ++L + + D T Sbjct: 422 IATGSGDNTCKVW----DLRQRRCVYTIPAHQNLVTGVKFEP--IHGNFLLTGAYDNTAK 475 Query: 233 IWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 IWT L + S G ++A D LW Sbjct: 476 IWTHPGWSP-----LKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 136 bits (343), Expect = 8e-33, Method: Composition-based stats. Identities = 47/236 (19%), Positives = 84/236 (35%), Gaps = 29/236 (12%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 V H + + G+ L T D++ +++++E + L GH V+ + + Sbjct: 316 VADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQ--EGHSMGVYDIAF 373 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 + G++ + D +W GR I H + + ++P+ G + S Sbjct: 374 H--QDGSLAGTGGLDAFGRVWDLRTGRC--IMFLEGHLKEIYGINFSPN--GYHIATGSG 427 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 D V + ++ I AH V + P +TG DN Sbjct: 428 DNTCKVWDLRQRRCVYTI--PAHQNLVTGVKFEPI------------HGNFLLTGAYDNT 473 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQD 237 KIW + + TL GH V + S +A+ S DRT +W + Sbjct: 474 AKIWTHPG----WSPLKTLAGHEGKVMGLDISSD---GQLIATCSYDRTFKLWMAE 522 Score = 99.9 bits (247), Expect = 1e-21, Method: Composition-based stats. Identities = 41/241 (17%), Positives = 84/241 (34%), Gaps = 37/241 (15%) Query: 48 TLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQW 107 + G + P+ ++ +LA+ + G +W + + + H+ +V ++ + Sbjct: 226 SQIGDDRPISYCHFSPN--SKMLATACWSGLCKLWSVPD--CNLLHTLRGHNTNVGAIVF 281 Query: 108 APHEYGPL------LLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEED 161 P L L ++DG V + + + I + H + V W P+ Sbjct: 282 HPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADI--EGHTVRVARVMWHPS----- 334 Query: 162 GEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSY 221 R T D ++W + + EGHS V D+A+ S Sbjct: 335 --------GRFLGTTCYDRSWRLWDLEAQEEILHQ----EGHSMGVYDIAFH---QDGSL 379 Query: 222 LASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 + D +W + ++ E ++ ++S +G +A GDN +W Sbjct: 380 AGTGGLDAFGRVWDLRTGR-----CIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVW 434 Query: 282 K 282 Sbjct: 435 D 435 Score = 67.5 bits (163), Expect = 6e-12, Method: Composition-based stats. Identities = 27/127 (21%), Positives = 46/127 (36%), Gaps = 14/127 (11%) Query: 167 TKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLR-----SY 221 + S+ T L K+W L TL GH+ V + + P + Sbjct: 240 SPNSKMLATACWSGLCKLWSVPD----CNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVN 295 Query: 222 LASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 LAS + D + +W+ D+++ + E + R W SG L + D LW Sbjct: 296 LASCAADGSVKLWSLDSDEP-----VADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLW 350 Query: 282 KENLEGK 288 + + Sbjct: 351 DLEAQEE 357 >3C9C-A nrPDB Length = 432 Score = 162 bits (409), Expect = 2e-40, Method: Composition-based stats. Identities = 67/313 (21%), Positives = 112/313 (35%), Gaps = 48/313 (15%) Query: 8 HNELIHDAVLDYYGK-RLATCSSDKTIKIFEVEG------ETHKLID--TLTGHEGPVWR 58 H ++ A +AT + + +F+ + + L GH+ + Sbjct: 129 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 188 Query: 59 VDWAHPKFGTILASCSYDGKVLIWKE-----ENGRWSQIAVHAVHSASVNSVQWAPHEYG 113 + W +P L S S D + +W E+ + H+A V V W + Sbjct: 189 LSW-NPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHL-LHE 246 Query: 114 PLLLVASSDGKVSVVEFKENGTTSP-IIIDAHAIGVNSASWAPATIEEDGEHNGTKESRK 172 L + D K+ + + + N T+ P +DAH VN S+ P + Sbjct: 247 SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI------------ 294 Query: 173 FVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 232 TG AD V +W + + + E H D + V WSP + LAS DR Sbjct: 295 LATGSADKTVALWDLRN---LKLKLHSFESHKDEIFQVQWSPHN--ETILASSGTDRRLH 349 Query: 233 IWTQ----------DNEQGPWKKTLLKEEKFPDVLWRASWSLSGN-VLALSGGDNKVTLW 281 +W D E GP + L + SW+ + ++ DN + +W Sbjct: 350 VWDLSKIGEEQSTEDAEDGPPEL-LFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 408 Query: 282 K--ENLEGKWEPA 292 + EN+ EP Sbjct: 409 QMAENVYNDEEPE 421 Score = 109 bits (271), Expect = 2e-24, Method: Composition-based stats. Identities = 53/257 (20%), Positives = 94/257 (36%), Gaps = 35/257 (13%) Query: 52 HEGPVWRVDWAHPKFGTILASCSYDGKVLIWK--------EENGRWSQIAVHAVHSASVN 103 HEG V R + P+ ++A+ + VL++ E +G H Sbjct: 129 HEGEVNRARY-MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 187 Query: 104 SVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII-----IDAHAIGVNSASWAPATI 158 + W P+ G LL AS D + + + +I H V +W Sbjct: 188 GLSWNPNLNG-YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH---- 242 Query: 159 EEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLL 218 F + D + IW ++ T T++ H+ V ++++P Sbjct: 243 --------LLHESLFGSVADDQKLMIWDTRNN-NTSKPSHTVDAHTAEVNCLSFNP--YS 291 Query: 219 RSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSG-NVLALSGGDNK 277 LA+ S D+T +W N K L E D +++ WS +LA SG D + Sbjct: 292 EFILATGSADKTVALWDLRN----LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRR 347 Query: 278 VTLWKENLEGKWEPAGE 294 + +W + G+ + + Sbjct: 348 LHVWDLSKIGEEQSTED 364 Score = 104 bits (259), Expect = 5e-23, Method: Composition-based stats. Identities = 36/143 (25%), Positives = 67/143 (46%), Gaps = 16/143 (11%) Query: 4 IANAHNELIHDAVLDYYGKR-LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 +AH ++ + Y + LAT S+DKT+ ++++ KL + H+ +++V W+ Sbjct: 274 TVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWS 332 Query: 63 HPKFGTILASCSYDGKVLIWKE------------ENGRWSQIAVHAVHSASVNSVQWAPH 110 P TILAS D ++ +W E+G + +H H+A ++ W P+ Sbjct: 333 -PHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPN 391 Query: 111 EYGPLLLVASSDGKVSVVEFKEN 133 E ++ S D + V + EN Sbjct: 392 EP-WIICSVSEDNIMQVWQMAEN 413 Score = 58.3 bits (139), Expect = 4e-09, Method: Composition-based stats. Identities = 34/190 (17%), Positives = 58/190 (30%), Gaps = 22/190 (11%) Query: 110 HEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKE 169 +E G S GK+ + I H VN A + P + + Sbjct: 106 NEKGEFGGFGSVCGKIEI-----------EIKINHEGEVNRARYMPQNACVIATKTPSSD 154 Query: 170 SRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDR 229 F + K + + L GH ++W+P + YL S S D Sbjct: 155 VLVF------DYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNG--YLLSASDDH 206 Query: 230 TCIIWTQDNEQGPWKKTLLKE--EKFPDVLWRASWSL-SGNVLALSGGDNKVTLWKENLE 286 T +W + + K V+ +W L ++ D K+ +W Sbjct: 207 TICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNN 266 Query: 287 GKWEPAGEVH 296 +P+ V Sbjct: 267 NTSKPSHTVD 276 Score = 27.1 bits (58), Expect = 8.5, Method: Composition-based stats. Identities = 6/37 (16%), Positives = 15/37 (40%), Gaps = 1/37 (2%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLA-TCSSDKTIKIF 36 ++ I H I D + + + S D ++++ Sbjct: 372 LLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 408 >2H9P-A nrPDB Length = 329 Score = 161 bits (408), Expect = 3e-40, Method: Composition-based stats. Identities = 53/238 (22%), Positives = 101/238 (42%), Gaps = 24/238 (10%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 + H+ + + + + S D++++I++V+ T K + TL H PV V Sbjct: 116 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK--TGKCLKTLPAHSDPVSAVH 173 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 + G+++ S SYDG IW +G+ + + + V+ V+++P+ G +L A+ Sbjct: 174 FNRD--GSLIVSSSYDGLCRIWDTASGQCLKTLI-DDDNPPVSFVKFSPN--GKYILAAT 228 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 D + + ++ + H + + V+G DN Sbjct: 229 LDNTLKLWDYSKGKCLKTY--TGHKNEKYCIF----------ANFSVTGGKWIVSGSEDN 276 Query: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDN 238 LV IW + QT + L+GH+D V A PT + + A++ D+T +W D Sbjct: 277 LVYIW----NLQTKEIVQKLQGHTDVVISTACHPTENIIAS-AALENDKTIKLWKSDC 329 Score = 158 bits (400), Expect = 2e-39, Method: Composition-based stats. Identities = 64/288 (22%), Positives = 111/288 (38%), Gaps = 37/288 (12%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 H + + G+ LA+ S+DK IKI+ + T++GH+ + V W+ Sbjct: 35 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGISDVAWSS 92 Query: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 +L S S D + IW +G+ + HS V + P L++ S D Sbjct: 93 D--SNLLVSASDDKTLKIWDVSSGKCLK--TLKGHSNYVFCCNFNPQ--SNLIVSGSFDE 146 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 V + + K + AH+ V++ + ++ V+ D L + Sbjct: 147 SVRIWDVKTGKCLK--TLPAHSDPVSAVHFN-------------RDGSLIVSSSYDGLCR 191 Query: 184 IWKYNSDAQTYVLESTLEGHSD-WVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGP 242 IW D + TL + V V +SP Y+ + + D T +W D +G Sbjct: 192 IW----DTASGQCLKTLIDDDNPPVSFVKFSPN---GKYILAATLDNTLKLW--DYSKGK 242 Query: 243 WKKTLLKEEKFPDVLWRASWSLSGNV-LALSGGDNKVTLWKENLEGKW 289 KT + A++S++G + DN V +W NL+ K Sbjct: 243 CLKTYTGHKN-EKYCIFANFSVTGGKWIVSGSEDNLVYIW--NLQTKE 287 Score = 95.3 bits (235), Expect = 3e-20, Method: Composition-based stats. Identities = 41/166 (24%), Positives = 62/166 (37%), Gaps = 32/166 (19%) Query: 138 PIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLE 197 + H V+S ++P + AD L+KIW A E Sbjct: 33 KFTLAGHTKAVSSVKFSP-------------NGEWLASSSADKLIKIW----GAYDGKFE 75 Query: 198 STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVL 257 T+ GH + DVAWS L L S S D+T IW D G KTL + + + Sbjct: 76 KTISGHKLGISDVAWSSDSNL---LVSASDDKTLKIW--DVSSGKCLKTL---KGHSNYV 127 Query: 258 WRASWSLSGNVLALSGGDNKVTLWK-------ENLEGKWEPAGEVH 296 + +++ N++ D V +W + L +P VH Sbjct: 128 FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH 173 Score = 68.7 bits (166), Expect = 3e-12, Method: Composition-based stats. Identities = 26/92 (28%), Positives = 42/92 (45%), Gaps = 8/92 (8%) Query: 193 TYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEK 252 Y L+ TL GH+ V V +SP +LAS S D+ IW G ++KT+ + Sbjct: 29 NYALKFTLAGHTKAVSSVKFSPN---GEWLASSSADKLIKIWG--AYDGKFEKTISGHKL 83 Query: 253 FPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 + +WS N+L + D + +W + Sbjct: 84 G---ISDVAWSSDSNLLVSASDDKTLKIWDVS 112 >2HES-X nrPDB Length = 330 Score = 160 bits (405), Expect = 6e-40, Method: Composition-based stats. Identities = 72/288 (25%), Positives = 119/288 (41%), Gaps = 35/288 (12%) Query: 16 VLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTL--TGHEGPVWRVDWAHPKFGTILASC 73 D+ LAT S+D+ IK+ V+ + LID L T H+ + V W ++LA+ Sbjct: 19 SFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRP--HTSLLAAG 76 Query: 74 SYDGKVLIWKEENG-----RWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 S+D V IW +E +A+ H V V W+ G L S D V + Sbjct: 77 SFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSND--GYYLATCSRDKSVWIW 134 Query: 129 EFKENGTTSPII--IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 E E+G I + H+ V W P+ + D+ V+IWK Sbjct: 135 ETDESGEEYECISVLQEHSQDVKHVIWHPS-------------EALLASSSYDDTVRIWK 181 Query: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT 246 D + + L GH V + T + L S S D T +W + ++ Sbjct: 182 DYDD--DWECVAVLNGHEGTVWSSDFDKTEGVF-RLCSGSDDSTVRVWKYMGDDEDDQQE 238 Query: 247 LLKEEKFPDV----LWRASWSLSGNVLALSGGDNKVTLWKENLEGKWE 290 + E PDV ++ +W +G ++A G D + +++E ++G+W+ Sbjct: 239 WVCEAILPDVHKRQVYNVAWGFNG-LIASVGADGVLAVYEE-VDGEWK 284 Score = 131 bits (329), Expect = 4e-31, Method: Composition-based stats. Identities = 77/291 (26%), Positives = 116/291 (39%), Gaps = 36/291 (12%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHK-----LIDTLTGHEGPVWRVD 60 AH + I + LA S D T+ I+ E + L+ + GHE V V Sbjct: 55 TAHKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVA 114 Query: 61 WAHPKFGTILASCSYDGKVLIW--KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 118 W++ G LA+CS D V IW E + I+V HS V V W P E LL Sbjct: 115 WSND--GYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSE--ALLAS 170 Query: 119 ASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGA 178 +S D V + + ++ +++ H V S+ + + T+ + +G Sbjct: 171 SSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDF-----------DKTEGVFRLCSGSD 219 Query: 179 DNLVKIWKY----NSDAQTYVLESTLEG-HSDWVRDVAWSPTVLLRSYLASVSQDRTCII 233 D+ V++WKY D Q +V E+ L H V +VAW L +ASV D + Sbjct: 220 DSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNGL----IASVGADGVLAV 275 Query: 234 WTQDNEQGPWK---KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 + G WK K L + + + +LA G D V W Sbjct: 276 --YEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGIVNFW 324 Score = 120 bits (300), Expect = 9e-28, Method: Composition-based stats. Identities = 56/246 (22%), Positives = 94/246 (38%), Gaps = 26/246 (10%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE--GETHKLIDTLTGHEGPVWR 58 ++ I H + G LATCS DK++ I+E + GE ++ I L H V Sbjct: 99 LLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKH 158 Query: 59 VDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 118 V W + +LAS SYD V IWK+ + W +AV H +V S + E L Sbjct: 159 VIWHPSEA--LLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCS 216 Query: 119 ASSDGKVSVVEF--KENGTTSPIIIDA-----HAIGVNSASWAPATIEEDGEHNGTKESR 171 S D V V ++ + + +A H V + +W + Sbjct: 217 GSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGF--------------NG 262 Query: 172 KFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTC 231 + GAD ++ +++ + L + V W + ++ LA+ D Sbjct: 263 LIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWL-ELNGKTILATGGDDGIV 321 Query: 232 IIWTQD 237 W+ + Sbjct: 322 NFWSLE 327 Score = 116 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 63/254 (24%), Positives = 99/254 (38%), Gaps = 38/254 (14%) Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVH--AVHSASVNSVQWAPHEYGPLLLV 118 W+ ILA+ S D K+ + + ++ I V H ++ SV W PH LL Sbjct: 18 WSFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHT--SLLAA 75 Query: 119 ASSDGKVSVVEFKENGTTS-----PIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKF 173 S D VS+ +E+ + II+ H V +W+ + Sbjct: 76 GSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWS-------------NDGYYL 122 Query: 174 VTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII 233 T D V IW+ + + Y S L+ HS V+ V W P+ L LAS S D T I Sbjct: 123 ATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEAL---LASSSYDDTVRI 179 Query: 234 WTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNV--LALSGGDNKVTLWK-----ENLE 286 W ++ L E +W + + + V L D+ V +WK E+ + Sbjct: 180 WKDYDDDWECVAVLNGHEG---TVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQ 236 Query: 287 GKWEPAG---EVHQ 297 +W +VH+ Sbjct: 237 QEWVCEAILPDVHK 250 Score = 91.8 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 44/196 (22%), Positives = 74/196 (37%), Gaps = 19/196 (9%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 + + H++ + + LA+ S D T++I++ + + + L GHEG VW D Sbjct: 145 CISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSD 204 Query: 61 WAHPKFGTILASCSYDGKVLIWK------EENGRWSQIAVH-AVHSASVNSVQWAPHEYG 113 + + L S S D V +WK ++ W A+ VH V +V W + Sbjct: 205 FDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAW---GFN 261 Query: 114 PLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKF 173 L+ +DG ++V E + +G A GV + Sbjct: 262 GLIASVGADGVLAVYE-EVDGEWKVFAKRALCHGVYEI--------NVVKWLELNGKTIL 312 Query: 174 VTGGADNLVKIWKYNS 189 TGG D +V W Sbjct: 313 ATGGDDGIVNFWSLEK 328 >6N9G-C nrPDB Length = 353 Score = 158 bits (400), Expect = 2e-39, Method: Composition-based stats. Identities = 48/227 (21%), Positives = 84/227 (37%), Gaps = 26/227 (11%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 H + ++ T S D T +++V E+ +L+ + GH V +D A + G Sbjct: 152 HTNYLSACSFTNSDMQILTASGDGTCALWDV--ESGQLLQSFHGHGADVLCLDLAPSETG 209 Query: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 S D K ++W +G+ Q H + VNSV++ P G S D + Sbjct: 210 NTFVSGGCDKKAMVWDMRSGQCVQ--AFETHESDVNSVRYYPS--GDAFASGSDDATCRL 265 Query: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 + + + + ++ G +S ++ + R G D + +W Sbjct: 266 YDLRADREVAIYSKESIIFGASSVDFSLS-------------GRLLFAGYNDYTINVW-- 310 Query: 188 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 D S L GH + V + SP + S S D T +W Sbjct: 311 --DVLKGSRVSILFGHENRVSTLRVSPD---GTAFCSGSWDHTLRVW 352 Score = 119 bits (297), Expect = 2e-27, Method: Composition-based stats. Identities = 49/276 (17%), Positives = 88/276 (31%), Gaps = 37/276 (13%) Query: 12 IHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTG----HEGPVWRVDWAHPKFG 67 + G +A D ++ + + ++ + H + + + Sbjct: 108 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDM- 166 Query: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 + + S DG +W E+G+ Q H A V + AP E G + D K V Sbjct: 167 -QILTASGDGTCALWDVESGQLLQS--FHGHGADVLCLDLAPSETGNTFVSGGCDKKAMV 223 Query: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 + + + H VNS + P+ F +G D +++ Sbjct: 224 WDMRSGQCVQAF--ETHESDVNSVRYYPS-------------GDAFASGSDDATCRLYDL 268 Query: 188 NSD--AQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKK 245 +D Y ES + G V +S L L + D T +W D +G Sbjct: 269 RADREVAIYSKESIIFG----ASSVDFS---LSGRLLFAGYNDYTINVW--DVLKGSRVS 319 Query: 246 TLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 L E + + S G D+ + +W Sbjct: 320 ILFGHE---NRVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 102 bits (253), Expect = 2e-22, Method: Composition-based stats. Identities = 48/247 (19%), Positives = 84/247 (34%), Gaps = 35/247 (14%) Query: 47 DTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKE-ENGRWSQIAVHAVHSASVNSV 105 TL GH V +DW K + S S DGKV++W + + + V + Sbjct: 57 RTLKGHGNKVLCMDWCKDK--RRIVSSSQDGKVIVWDSFTTNKEHAVTMPCT---WVMAC 111 Query: 106 QWAPHEYGPLLLVASSDGKVSVV----EFKENGTTSPIIIDAHAIGVNSASWAPATIEED 161 +AP G + D K SV + EN + H +++ S+ Sbjct: 112 AYAPS--GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSF-------- 161 Query: 162 GEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSY 221 T + +T D +W D ++ L + GH V + +P+ + Sbjct: 162 -----TNSDMQILTASGDGTCALW----DVESGQLLQSFHGHGADVLCLDLAPSET-GNT 211 Query: 222 LASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 S D+ ++W D G + E + + SG+ A D L+ Sbjct: 212 FVSGGCDKKAMVW--DMRSGQCVQAF---ETHESDVNSVRYYPSGDAFASGSDDATCRLY 266 Query: 282 KENLEGK 288 + + Sbjct: 267 DLRADRE 273 Score = 75.6 bits (184), Expect = 2e-14, Method: Composition-based stats. Identities = 23/128 (17%), Positives = 49/128 (38%), Gaps = 6/128 (4%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 V H ++ G A+ S D T +++++ + I + VD Sbjct: 231 CVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 290 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 ++ G +L + D + +W G S++++ H V++++ +P G S Sbjct: 291 FS--LSGRLLFAGYNDYTINVWDVLKG--SRVSILFGHENRVSTLRVSPD--GTAFCSGS 344 Query: 121 SDGKVSVV 128 D + V Sbjct: 345 WDHTLRVW 352 Score = 45.6 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 20/92 (21%), Positives = 36/92 (39%), Gaps = 8/92 (8%) Query: 198 STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVL 257 TL+GH + V + W + + S SQD I+W T+ + Sbjct: 57 RTLKGHGNKVLCMDWC---KDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCT-----WV 108 Query: 258 WRASWSLSGNVLALSGGDNKVTLWKENLEGKW 289 +++ SG +A G DNK +++ + Sbjct: 109 MACAYAPSGCAIACGGLDNKCSVYPLTFDKNE 140 Score = 35.2 bits (79), Expect = 0.039, Method: Composition-based stats. Identities = 9/46 (19%), Positives = 14/46 (30%) Query: 244 KKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKW 289 KT + + + W + S D KV +W K Sbjct: 53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKE 98 >5WJC-A nrPDB Length = 430 Score = 155 bits (392), Expect = 2e-38, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 109/301 (36%), Gaps = 47/301 (15%) Query: 8 HNELIHDAVLDYYG-KRLATCSSDKTIKIFE------VEGETHKLIDTLTGHEGPVWRVD 60 H+ ++ A + +AT IF+ + L GH + + Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRW--------SQIAVHAVHSASVNSVQWAPHEY 112 W +P LA+ + D + +W + + S IA + H+ VN VQ+ P ++ Sbjct: 190 W-NPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHP-QH 247 Query: 113 GPLLLVASSDGKVSVVEFKENGTTS-PIIIDAHAIGVNSASWAPATIEEDGEHNGTKESR 171 LL S D + + + + N P +I AH+ +N+ + P Sbjct: 248 EALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFN------------DY 295 Query: 172 KFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTC 231 T AD V +W + Q TLEGH D V + WSP LAS S DR Sbjct: 296 LLATASADKTVALWDLRNPYQRL---HTLEGHEDEVYGLEWSPHD--EPILASSSTDRRV 350 Query: 232 IIWTQ----------DNEQGPWKKTLLKEEKFPDVLWRASWSLSGN-VLALSGGDNKVTL 280 IW D E G + L + + SW + V+ DN + + Sbjct: 351 CIWDLEKIGEEQTPEDAEDGSPEL-LFMHGGHTNRISEFSWCPNERWVVGSLADDNILQI 409 Query: 281 W 281 W Sbjct: 410 W 410 Score = 109 bits (273), Expect = 1e-24, Method: Composition-based stats. Identities = 36/138 (26%), Positives = 67/138 (48%), Gaps = 16/138 (11%) Query: 4 IANAHNELIHDAVLDYYGK-RLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 + AH++ I+ ++ + LAT S+DKT+ ++++ +L TL GHE V+ ++W+ Sbjct: 276 VIQAHSKAINAVAINPFNDYLLATASADKTVALWDLRNPYQRL-HTLEGHEDEVYGLEWS 334 Query: 63 HPKFGTILASCSYDGKVLIWKE------------ENGRWSQIAVHAVHSASVNSVQWAPH 110 P ILAS S D +V IW E+G + +H H+ ++ W P+ Sbjct: 335 -PHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPN 393 Query: 111 EYGPLLLVASSDGKVSVV 128 E ++ + D + + Sbjct: 394 ER-WVVGSLADDNILQIW 410 Score = 99.9 bits (247), Expect = 1e-21, Method: Composition-based stats. Identities = 53/254 (20%), Positives = 89/254 (35%), Gaps = 36/254 (14%) Query: 52 HEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEE------NGRWSQIAVHAVHSASVNSV 105 H+G V R + P+ I+A+ G I+ G AV H+A + Sbjct: 130 HDGDVNRARY-MPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGL 188 Query: 106 QWAPHEYGPLLLVASSDGKVSVVEFK-------ENGTTSPIIIDA-HAIGVNSASWAPAT 157 W P+ G L + D + + + + E SPI H VN + P Sbjct: 189 CWNPNLPGN-LATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHP-- 245 Query: 158 IEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVL 217 + + D ++I + + ++ HS + VA +P Sbjct: 246 ----------QHEALLASVSDDCTLQIHDTRLNPEE-EAPKVIQAHSKAINAVAINP--F 292 Query: 218 LRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGN-VLALSGGDN 276 LA+ S D+T +W N + L E D ++ WS +LA S D Sbjct: 293 NDYLLATASADKTVALWDLRN----PYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDR 348 Query: 277 KVTLWKENLEGKWE 290 +V +W G+ + Sbjct: 349 RVCIWDLEKIGEEQ 362 >4XFV-A nrPDB Length = 792 Score = 155 bits (391), Expect = 2e-38, Method: Composition-based stats. Identities = 67/306 (21%), Positives = 112/306 (36%), Gaps = 47/306 (15%) Query: 22 KRLATCSSDKTIKIFE-VEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 K++ + KTI +++ +E + TL GHE V V + + S S D V Sbjct: 31 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD--SDFMVSASEDHHVK 88 Query: 81 IWKEENGRWSQIAVHAVH-SASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI 139 IWK + Q H S ++ ++ P L+ V +DG +S+ ++N Sbjct: 89 IWKFTDYSHLQCIQTIQHYSKTIVALSALPS----LISVGCADGTISIW--RQNIQNDEF 142 Query: 140 IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY---NSDAQTYVL 196 + AH + + P + GG + V I + +S + + Sbjct: 143 GL-AHEFTIKKGFFYPLCLSLSKVEEKK---YLLAIGGTNVNVFIASFILSDSGIEKCRV 198 Query: 197 ESTLEGHSDWVRDVAWSPTVLLRSY-LASVSQDRTCIIWT-------QDNEQGPWKKTLL 248 + LEGH DWV+ +A+ Y L S SQDR +W D+E+ K TLL Sbjct: 199 VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLL 258 Query: 249 KEE---------------------KFPDVLWRASWSLSGNVLALSGGDNKVTLWK-ENLE 286 + D + W S L + D + +W+ + Sbjct: 259 SNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETS 318 Query: 287 GKWEPA 292 G W + Sbjct: 319 GIWVCS 324 Score = 75.2 bits (183), Expect = 3e-14, Method: Composition-based stats. Identities = 51/263 (19%), Positives = 99/263 (37%), Gaps = 33/263 (12%) Query: 39 EGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGK-----VLIWKEENGRWSQIA 93 ++ L GH + +D + + ++AS + I+ EN W +I Sbjct: 548 RHLLWPEVEKLYGHGFEITCLDISPDQK--LIASACRSNNVQNAVIRIFSTEN--WLEIK 603 Query: 94 V-HAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDA---HAIGVN 149 HS ++ ++++ G LL D K ++ E T + H + Sbjct: 604 PALPFHSLTITRLKFSKD--GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIW 661 Query: 150 SASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN-SDAQTYVLESTLEGHSDWVR 208 A WAP FVT D VK+W++ A YVLE++++ H+ V Sbjct: 662 DADWAPLEF-----------GNVFVTASRDKTVKVWRHQKEPADDYVLEASIK-HTKAVT 709 Query: 209 DVAWSPTVLLRSYLASVS-QDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWS---L 264 ++ +++ L SV ++ +++ + L ++ D + R WS Sbjct: 710 AISIHDSMIREKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKR 769 Query: 265 SGNV-LALSGGDNKVTLWKENLE 286 +G + L + D ++ E Sbjct: 770 NGKLFLGVGSSDLSTRIYSLAYE 792 Score = 71.4 bits (173), Expect = 5e-13, Method: Composition-based stats. Identities = 47/246 (19%), Positives = 91/246 (36%), Gaps = 26/246 (10%) Query: 7 AHNELIHDAVLDYYGKRLATC--SSDKT---IKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 H I + K +A+ S++ I+IF E ++ L H + R+ + Sbjct: 560 GHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTEN-WLEIKPALPFHSLTITRLKF 618 Query: 62 AHPKFGTILASCSYDGKVLIWK---EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 118 + K G L S D K +W+ E+N + H+ + WAP E+G + + Sbjct: 619 S--KDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVT 676 Query: 119 ASSDGKVSVVEFKENGTTSPIIIDA--HAIGVNSASWAPATIEEDGEHNGTKESRKFVTG 176 AS D V V ++ ++ + H V + S H+ + ++ Sbjct: 677 ASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISI----------HDSMIREKILISV 726 Query: 177 GADN-LVKIWKYNSDA-QTYVLESTLEGHSDWVRDVAWSPTVLLRS-YLASVSQDRTCII 233 G +N + ++ Y + + +D + + WS +L S D + I Sbjct: 727 GLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRI 786 Query: 234 WTQDNE 239 ++ E Sbjct: 787 YSLAYE 792 Score = 62.5 bits (150), Expect = 2e-10, Method: Composition-based stats. Identities = 32/207 (15%), Positives = 69/207 (33%), Gaps = 28/207 (13%) Query: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLT------------ 50 + H++ I +L ++D ++ ++E + + + +L Sbjct: 279 ALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTA 338 Query: 51 -GHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENG-RWSQIAVHAVHSASVNSVQWA 108 G G W W + + G +W ++ Q + + V + W+ Sbjct: 339 TGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWS 398 Query: 109 PHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHN--- 165 P G LL S D + +P I DA A+W + + ++ Sbjct: 399 PS--GEYLLATSLDQTTRLF--------APWIYDASGRKREIATWHEFSRPQIHGYDMIC 448 Query: 166 -GTKESRKFVTGGADNLVKIWKYNSDA 191 T +FV+GG + +++ + Sbjct: 449 VETVTDTRFVSGGDEKILRSFDLPKGV 475 Score = 54.8 bits (130), Expect = 4e-08, Method: Composition-based stats. Identities = 45/301 (14%), Positives = 87/301 (28%), Gaps = 47/301 (15%) Query: 22 KRLATCSSDKTIKIFEVEGETHKLIDTL--TGHEGPVWRVDWAHPKFGTILASCSYDGKV 79 T + +++ + + L +G V + W+ G L + S D Sbjct: 357 DFFLTNGKTGSWRMWATK-DNIICDQRLGISGATKDVTDIAWSP--SGEYLLATSLDQTT 413 Query: 80 LI---W-------KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVE 129 + W K E W + + +H + V+ + + + + Sbjct: 414 RLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTR---FVSGGDEKILRSFD 470 Query: 130 FKENGTT-----SPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 + I + + +SA+ + + E + GG I Sbjct: 471 LPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDI 530 Query: 185 WKYNSDAQT------------YVLESTLEGHSDWVRDVAWSPTVLLRSYLASVS-----Q 227 S + + L GH + + SP L +AS Q Sbjct: 531 TDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKL---IASACRSNNVQ 587 Query: 228 DRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEG 287 + I++ +N W + + R +S G L D K LW+ N+E Sbjct: 588 NAVIRIFSTEN----WLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMED 643 Query: 288 K 288 Sbjct: 644 N 644 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 8/76 (10%), Positives = 23/76 (30%), Gaps = 2/76 (2%) Query: 222 LASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 + + +T +W D + K + + + + + + D+ V +W Sbjct: 33 IVAFGAGKTIALW--DPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 90 Query: 282 KENLEGKWEPAGEVHQ 297 K + + Sbjct: 91 KFTDYSHLQCIQTIQH 106 >3CFV-B nrPDB Length = 414 Score = 154 bits (389), Expect = 4e-38, Method: Composition-based stats. Identities = 69/310 (22%), Positives = 110/310 (35%), Gaps = 48/310 (15%) Query: 8 HNELIHDAVLDYYG-KRLATCSSDKTIKIFEVE------GETHKLID--TLTGHEGPVWR 58 H ++ A +AT + + +F+ + + L GH+ + Sbjct: 125 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 184 Query: 59 VDWAHPKFGTILASCSYDGKVLIWKEENGR-----WSQIAVHAVHSASVNSVQWAPHEYG 113 + W + L S S D V +W G A+ HSA V V W + Sbjct: 185 LSW-NSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHL-LHE 242 Query: 114 PLLLVASSDGKVSVVEFKENGTTSP-IIIDAHAIGVNSASWAPATIEEDGEHNGTKESRK 172 L + D K+ + + + N T+ P ++DAH VN S+ P + Sbjct: 243 SLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFI------------ 290 Query: 173 FVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 232 TG AD V +W + + T E H D + V WSP + LAS DR Sbjct: 291 LATGSADKTVALWDLRN---LKLKLHTFESHKDEIFQVHWSPHN--ETILASSGTDRRLN 345 Query: 233 IWTQ----------DNEQGPWKKTLLKEEKFPDVLWRASWSLSGN-VLALSGGDNKVTLW 281 +W D E GP + L + SW+ + V+ DN + +W Sbjct: 346 VWDLSKIGEEQSAEDAEDGPPEL-LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 404 Query: 282 K--ENLEGKW 289 + EN+ Sbjct: 405 QMAENIYNDE 414 Score = 105 bits (262), Expect = 2e-23, Method: Composition-based stats. Identities = 55/257 (21%), Positives = 95/257 (36%), Gaps = 35/257 (13%) Query: 52 HEGPVWRVDWAHPKFGTILASCSYDGKVLIWK--------EENGRWSQIAVHAVHSASVN 103 HEG V R + P+ I+A+ + VL++ + +G + H Sbjct: 125 HEGEVNRARY-MPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGY 183 Query: 104 SVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI-----IIDAHAIGVNSASWAPATI 158 + W + G LL AS D V + + I I H+ V +W Sbjct: 184 GLSWNSNLSGHLL-SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWH---- 238 Query: 159 EEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLL 218 F + D + IW S+ T ++ H+ V ++++P Sbjct: 239 --------LLHESLFGSVADDQKLMIWDTRSNT-TSKPSHLVDAHTAEVNCLSFNP--YS 287 Query: 219 RSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSG-NVLALSGGDNK 277 LA+ S D+T +W N K L E D +++ WS +LA SG D + Sbjct: 288 EFILATGSADKTVALWDLRN----LKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRR 343 Query: 278 VTLWKENLEGKWEPAGE 294 + +W + G+ + A + Sbjct: 344 LNVWDLSKIGEEQSAED 360 Score = 104 bits (260), Expect = 4e-23, Method: Composition-based stats. Identities = 36/148 (24%), Positives = 68/148 (45%), Gaps = 16/148 (10%) Query: 4 IANAHNELIHDAVLDYYGKR-LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 + +AH ++ + Y + LAT S+DKT+ ++++ KL T H+ +++V W+ Sbjct: 270 LVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL-HTFESHKDEIFQVHWS 328 Query: 63 HPKFGTILASCSYDGKVLIWKE------------ENGRWSQIAVHAVHSASVNSVQWAPH 110 P TILAS D ++ +W E+G + +H H+A ++ W P+ Sbjct: 329 -PHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPN 387 Query: 111 EYGPLLLVASSDGKVSVVEFKENGTTSP 138 E ++ S D + + + EN Sbjct: 388 EP-WVICSVSEDNIMQIWQMAENIYNDE 414 Score = 95.7 bits (236), Expect = 2e-20, Method: Composition-based stats. Identities = 37/203 (18%), Positives = 74/203 (36%), Gaps = 29/203 (14%) Query: 3 VIANAHNELIHDAVLD-YYGKRLATCSSDKTIKIFEVEGE-THKLIDTLTGHEGPVWRVD 60 I H+ ++ D + + + D+ + I++ T K + H V + Sbjct: 223 AIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLS 282 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 + +P ILA+ S D V +W N + ++ H + V W+PH +L + Sbjct: 283 F-NPYSEFILATGSADKTVALWDLRNLKL-KLHTFESHKDEIFQVHWSPH-NETILASSG 339 Query: 121 SDGKVSVVEFKENGTTSP------------IIIDAHAIGVNSASWAPATIEEDGEHNGTK 168 +D +++V + + G I H ++ SW P Sbjct: 340 TDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPN------------ 387 Query: 169 ESRKFVTGGADNLVKIWKYNSDA 191 E + DN+++IW+ + Sbjct: 388 EPWVICSVSEDNIMQIWQMAENI 410 Score = 54.4 bits (129), Expect = 6e-08, Method: Composition-based stats. Identities = 30/167 (17%), Positives = 50/167 (29%), Gaps = 11/167 (6%) Query: 133 NGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQ 192 G I H VN A + P + + F D K + + Sbjct: 114 TGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVF-----DYTKHPAKPDPSGE 168 Query: 193 TYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDN--EQGPWKKTLLKE 250 L GH ++W L +L S S D T +W + ++G Sbjct: 169 CNPDLR-LRGHQKEGYGLSW--NSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIF 225 Query: 251 EKFPDVLWRASWSL-SGNVLALSGGDNKVTLWKENLEGKWEPAGEVH 296 V+ +W L ++ D K+ +W +P+ V Sbjct: 226 TGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVD 272 >4BTS-AR nrPDB Length = 343 Score = 153 bits (385), Expect = 1e-37, Method: Composition-based stats. Identities = 57/250 (22%), Positives = 97/250 (38%), Gaps = 41/250 (16%) Query: 49 LTGHEGPVWRVDWAHPK----FGTILASCSYDGKVLIWK----EENGRW-SQIAVHAVHS 99 L GH V + + +L S S D V+IWK E+NG + H+ Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHN 76 Query: 100 ASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIE 159 V+ + + + + +S D + + + + T + H V S +++P Sbjct: 77 HFVSDLALS--QENCFAISSSWDKTLRLWDLRTGTTYKRFV--GHQSEVYSVAFSP---- 128 Query: 160 EDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLR 219 ++R+ ++ GA+ +K+W + + E E HSDWV V +SP + Sbjct: 129 ---------DNRQILSAGAEREIKLWNILGECKFSSAEK--ENHSDWVSCVRYSPIMKSA 177 Query: 220 -------SYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALS 272 Y ASV D +W N + T E + L S S +G +A Sbjct: 178 NKVQPFAPYFASVGWDGRLKVW---NTNFQIRYTFKAHESNVNHL---SISPNGKYIATG 231 Query: 273 GGDNKVTLWK 282 G D K+ +W Sbjct: 232 GKDKKLLIWD 241 Score = 126 bits (317), Expect = 8e-30, Method: Composition-based stats. Identities = 55/296 (18%), Positives = 109/296 (36%), Gaps = 34/296 (11%) Query: 4 IANAHNELIHDAVLDYYGKR------LATCSSDKTIKIFEVEGETHKLI-----DTLTGH 52 I H++ + V + K L + S DKT+ I+++ E LTGH Sbjct: 16 ILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGH 75 Query: 53 EGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEY 112 V + + S S+D + +W G + H + V SV ++P Sbjct: 76 NHFVSDLALSQENC--FAISSSWDKTLRLWDLRTGTTYKR--FVGHQSEVYSVAFSPD-- 129 Query: 113 GPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRK 172 +L A ++ ++ + S + H+ V+ ++P + Sbjct: 130 NRQILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAP---Y 186 Query: 173 FVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 232 F + G D +K+W N + + T + H V ++ SP Y+A+ +D+ + Sbjct: 187 FASVGWDGRLKVWNTN-----FQIRYTFKAHESNVNHLSISPN---GKYIATGGKDKKLL 238 Query: 233 IWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGK 288 IW N P ++ + + +++ +A G D V ++ + K Sbjct: 239 IWDILNLTYPQREFDAG-----STINQIAFNPKLQWVA-VGTDQGVKIFNLMTQSK 288 Score = 120 bits (300), Expect = 8e-28, Method: Composition-based stats. Identities = 51/291 (17%), Positives = 94/291 (32%), Gaps = 44/291 (15%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 HN + D L + S DKT++++++ T GH+ V+ V ++ Sbjct: 72 LTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLR--TGTTYKRFVGHQSEVYSVAFSPD 129 Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAP--------HEYGPLL 116 + S + ++ +W A HS V+ V+++P + P Sbjct: 130 N--RQILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYF 187 Query: 117 LVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTG 176 DG++ V AH VN S +P + TG Sbjct: 188 ASVGWDGRLKVWNTNFQIR---YTFKAHESNVNHLSISP-------------NGKYIATG 231 Query: 177 GADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ 236 G D + IW + TY G + + +A++P + +V D+ I+ Sbjct: 232 GKDKKLLIWDILN--LTYPQREFDAGST--INQIAFNPKLQW----VAVGTDQGVKIFNL 283 Query: 237 DNEQGPWKKTLLKE--------EKFPDVLWRASWSLSGNVLALSGGDNKVT 279 + T+ E + +W+ G L D + Sbjct: 284 MTQSKAPVCTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFAGFTDGVIR 334 Score = 48.3 bits (113), Expect = 4e-06, Method: Composition-based stats. Identities = 23/141 (16%), Positives = 49/141 (34%), Gaps = 18/141 (12%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 AH ++ + GK +AT DK + I+++ T+ + G + ++ + +PK Sbjct: 210 KAHESNVNHLSISPNGKYIATGGKDKKLLIWDILNLTYPQREFDAG--STINQIAF-NPK 266 Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHA-----------VHSASVNSVQWAPHEYGP 114 + D V I+ + + + S+ W + G Sbjct: 267 LQWVAV--GTDQGVKIFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQCTSLAW--NALGK 322 Query: 115 LLLVASSDGKVSVVEFKENGT 135 L +DG + F+ + Sbjct: 323 KLFAGFTDGVIRTFSFETSAN 343 >5WYJ-BC nrPDB Length = 817 Score = 148 bits (374), Expect = 2e-36, Method: Composition-based stats. Identities = 61/296 (20%), Positives = 108/296 (36%), Gaps = 44/296 (14%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHK--LIDTLTGHEGPVWRV 59 V I H +L++ G +AT S D T ++ + K + GH V V Sbjct: 381 VEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAV 440 Query: 60 ---DWAHPKFGTILASCSYDGKVLIW---------KEENGRWSQIAVHAVHSASVNSVQW 107 + + L + S D + W + + S+ HA H +N++ Sbjct: 441 GLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHA-HEKDINALSV 499 Query: 108 APHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGT 167 +P++ + AS D + + + + H G+ S+ Sbjct: 500 SPND--SIFATASYDKTCKIWNLENGELEA--TLANHKRGLWDVSFC------------- 542 Query: 168 KESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQ 227 + + T D VKIW + T+ + TLEGH++ V+ ++ + + L S Sbjct: 543 QYDKLLATSSGDKTVKIWSLD----TFSVMKTLEGHTNAVQRCSF---INKQKQLISCGA 595 Query: 228 DRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKE 283 D IW D G KTL + + LW S G+++ + D WK+ Sbjct: 596 DGLIKIW--DCSSGECLKTL---DGHNNRLWALSTMNDGDMIVSADADGVFQFWKD 646 Score = 115 bits (288), Expect = 2e-26, Method: Composition-based stats. Identities = 59/275 (21%), Positives = 104/275 (37%), Gaps = 37/275 (13%) Query: 29 SDKTIKIFEV------EGETHKLIDTLTGHEGPVWRVDWAHPKFGTI-LASCSYD-GKVL 80 SD+T+++ V + +T ++ ++ G+ G + + + P+ + LA+ S + Sbjct: 307 SDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIP 366 Query: 81 IWKEENGRWS---QIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTS 137 + S + ++ H +NS+ E G + AS D V + EN Sbjct: 367 VPDLSGPEASLPLDVEIYEGHEDLLNSLDAT--EDGLWIATASKDNTAIVWRYNENSCKF 424 Query: 138 PII--IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQ--- 192 I H+ V + P + + +T D +K W Sbjct: 425 DIYAKYIGHSAAVTAVGL-PNIVSKGYPEF-------LLTASNDLTIKKWIIPKPTASMD 476 Query: 193 ---TYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLK 249 V E T H + ++ SP S A+ S D+TC IW +N G + TL Sbjct: 477 VQIIKVSEYTRHAHEKDINALSVSPND---SIFATASYDKTCKIWNLEN--GELEATLAN 531 Query: 250 EEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 ++ LW S+ +LA S GD V +W + Sbjct: 532 HKRG---LWDVSFCQYDKLLATSSGDKTVKIWSLD 563 Score = 98.7 bits (244), Expect = 2e-21, Method: Composition-based stats. Identities = 46/231 (19%), Positives = 92/231 (39%), Gaps = 25/231 (10%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 AH + I+ + AT S DKT KI+ +E +L TL H+ +W V + ++ Sbjct: 489 AHEKDINALSVSPNDSIFATASYDKTCKIWNLEN--GELEATLANHKRGLWDVSFC--QY 544 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 +LA+ S D V IW + +S + H+ +V + + L+ +DG + Sbjct: 545 DKLLATSSGDKTVKIWSLDT--FSVMKTLEGHTNAVQRCSFINKQ--KQLISCGADGLIK 600 Query: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 + + +D H N+ WA +T+ + V+ AD + + WK Sbjct: 601 IWDCSSGECLK--TLDGH----NNRLWALSTM---------NDGDMIVSADADGVFQFWK 645 Query: 187 --YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 + + ++ L+ + S ++L +++ D ++ Sbjct: 646 DCTEQEIEEEQEKAKLQVEQEQSLQNYMSKGDWTNAFLLAMTLDHPMRLFN 696 Score = 84.5 bits (207), Expect = 6e-17, Method: Composition-based stats. Identities = 44/295 (14%), Positives = 96/295 (32%), Gaps = 33/295 (11%) Query: 6 NAHNELIHDAVLDYYGKR------LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRV 59 H I YG+ LA+ ++ +K++++ K + TL H V + Sbjct: 141 KGHGGTISSLKF--YGQLNSKIWLLASGDTNGMVKVWDLV--KRKCLHTLQEHTSAVRGL 196 Query: 60 DWA----HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPL 115 D + + L S D + +W + ++ + V S + G Sbjct: 197 DIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKR 256 Query: 116 LL-VASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFV 174 ++ A D +++ + V + P + + Sbjct: 257 IIYTAGGDAIFQLIDSESGS-------------VLKRTNKPIEELFIIGVLPILSNSQMF 303 Query: 175 TGGADNLVKIWKYNSDAQ----TYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQD-R 229 +D +++ D + T + S++ G+ + D+ + L + LA+ S R Sbjct: 304 LVLSDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLR 363 Query: 230 TCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 + + + E D+L + G +A + DN +W+ N Sbjct: 364 IIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYN 418 Score = 58.3 bits (139), Expect = 4e-09, Method: Composition-based stats. Identities = 38/229 (16%), Positives = 85/229 (37%), Gaps = 24/229 (10%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 I+N + I L G+ L S + +KIF ++ T K++ ++ + + Sbjct: 56 ISNEDEQEITALKLTPDGQYLTYVSQAQLLKIFHLK--TGKVVRSMK-----ISSPSYIL 108 Query: 64 PKFGT--ILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQW--APHEYGPLLLVA 119 T +LA DG +++ ENG + H +++S+++ + LL Sbjct: 109 DADSTSTLLAVGGTDGSIIVVDIENGYIT--HSFKGHGGTISSLKFYGQLNSKIWLLASG 166 Query: 120 SSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGAD 179 ++G V V + + + H V + + S ++GG D Sbjct: 167 DTNGMVKVWDLVKRKCL--HTLQEHTSAVRGLD-------IIEVPDNDEPSLNLLSGGRD 217 Query: 180 NLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQD 228 +++ +W +N + +L++ V + + + + D Sbjct: 218 DIINLWDFNMKKKCKLLKTLPVNQQ--VESCGFLKDGDGKRIIYTAGGD 264 Score = 52.1 bits (123), Expect = 3e-07, Method: Composition-based stats. Identities = 23/189 (12%), Positives = 53/189 (28%), Gaps = 24/189 (12%) Query: 99 SASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATI 158 + +++ P G L S + + K + I Sbjct: 61 EQEITALKLTPD--GQYLTYVSQAQLLKIFHLKTGKVVRSMKIS---------------- 102 Query: 159 EEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLL 218 + S GG D + + D + + + +GH + + + + Sbjct: 103 SPSYILDADSTSTLLAVGGTDGSIIV----VDIENGYITHSFKGHGGTISSLKFYGQLNS 158 Query: 219 RSYL-ASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNV-LALSGGDN 276 + +L AS + +W + + + ++ L G D+ Sbjct: 159 KIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDD 218 Query: 277 KVTLWKENL 285 + LW N+ Sbjct: 219 IINLWDFNM 227 >3JB9-g nrPDB Length = 558 Score = 147 bits (371), Expect = 5e-36, Method: Composition-based stats. Identities = 53/279 (18%), Positives = 97/279 (34%), Gaps = 29/279 (10%) Query: 6 NAHNELIHDAVLDY-YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 H + I G L + S D IKI+EV + L+ T GH P+ + ++ Sbjct: 263 KGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHD-RSLLRTFQGHARPIRDLSFS-- 319 Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPL-LLVASSDG 123 + G S S+D + +W E G+ + N V++ P L ++D Sbjct: 320 QDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLT---NCVKFQVDPDKPNEFLAGTADK 376 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 ++ + + D H G+NS ++ + ++FVT D+ ++ Sbjct: 377 RILQFDIRSPDIVQAY--DHHLGGINSITF-------------LENGKRFVTTSDDSSMR 421 Query: 184 IWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPW 243 W+Y + + HS + VA P +A S D +++ + Sbjct: 422 FWEYGTPVPIKFVADIAM-HS--MPRVALRPN---GKSIACQSLDNCIYVYSAYEKYRQN 475 Query: 244 KKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 KK + K +S G + W Sbjct: 476 KKKVFKGYSCSGYSLEVGFSPDGRFVFSGDSSGNACFWD 514 Score = 84.9 bits (208), Expect = 4e-17, Method: Composition-based stats. Identities = 46/287 (16%), Positives = 88/287 (30%), Gaps = 35/287 (12%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE-GETHKLIDTLTGHEGPVWRV 59 ++ H I D G+ + S DKTIK+++ E G+ ++ + V Sbjct: 302 LLRTFQGHARPIRDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNS----DRLTNCV 357 Query: 60 DW-AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 118 + P + + D ++L + + Q + H +NS+ + E G + Sbjct: 358 KFQVDPDKPNEFLAGTADKRILQFDIRSPDIVQ--AYDHHLGGINSITFL--ENGKRFVT 413 Query: 119 ASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGA 178 S D + E+ GT PI A + + Sbjct: 414 TSDDSSMRFWEY---GTPVPIKFVA-----------DIAMHSMPRVALRPNGKSIACQSL 459 Query: 179 DNLVKIWK-YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQD 237 DN + ++ Y Q S + +V +SP ++ S W Sbjct: 460 DNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSPD---GRFVFSGDSSGNACFWDW- 515 Query: 238 NEQGPWKKTLLKEEKFPDVLWRASWSLS-GNVLALSG-GDNKVTLWK 282 K + K + ++ + +A S D + W Sbjct: 516 ----KTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKYWD 558 Score = 65.2 bits (157), Expect = 3e-11, Method: Composition-based stats. Identities = 30/213 (14%), Positives = 62/213 (29%), Gaps = 63/213 (29%) Query: 109 PHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTK 168 P++ G L + + H G++ + P + Sbjct: 236 PNDVGINLSEEPGEQTCYIP------KKHIFTWKGHTKGISCLRFFPISGHL-------- 281 Query: 169 ESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQD 228 ++G DN +KIW+ D L T +GH+ +RD+++S S S D Sbjct: 282 ----LLSGSMDNQIKIWEVYHDRS---LLRTFQGHARPIRDLSFS---QDGRSFLSTSFD 331 Query: 229 RTCIIWTQD-----NEQGPWKKT----------------------------------LLK 249 +T +W + N + T + Sbjct: 332 KTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDIRSPDIVQA 391 Query: 250 EEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 + + ++ +G + D+ + W+ Sbjct: 392 YDHHLGGINSITFLENGKRFVTTSDDSSMRFWE 424 >4XYI-A nrPDB Length = 430 Score = 143 bits (360), Expect = 9e-35, Method: Composition-based stats. Identities = 64/301 (21%), Positives = 112/301 (37%), Gaps = 47/301 (15%) Query: 8 HNELIHDAVLDYYG-KRLATCSSDKTIKIFEVEGETHK------LIDTLTGHEGPVWRVD 60 H ++ A +AT + IF++ + L H + + Sbjct: 130 HEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLG 189 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWS--------QIAVHAVHSASVNSVQWAPHEY 112 W + GT LA+ + D + +W + S ++V+ H+A VN +Q+ ++ Sbjct: 190 WNFIQEGT-LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHL-QH 247 Query: 113 GPLLLVASSDGKVSVVEFK-ENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESR 171 LL S D + + + + + +++ + AH VN ++ P Sbjct: 248 EALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFN------------DY 295 Query: 172 KFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTC 231 T AD+ V +W Q TLEGH D V +V WSP L + S DR Sbjct: 296 LLATASADHTVALWDLRRLNQRL---HTLEGHEDEVYNVQWSPHD--EPILVTSSTDRRV 350 Query: 232 IIWTQ----------DNEQGPWKKTLLKEEKFPDVLWRASWSLSGN-VLALSGGDNKVTL 280 +W D+E G + + + + SW+ + VLA DN + + Sbjct: 351 CVWDLSKIGEEQTVEDSEDGAPEL-MFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQI 409 Query: 281 W 281 W Sbjct: 410 W 410 Score = 111 bits (276), Expect = 5e-25, Method: Composition-based stats. Identities = 33/137 (24%), Positives = 61/137 (44%), Gaps = 16/137 (11%) Query: 5 ANAHNELIHDAVLDYYGK-RLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 AH + ++ + + LAT S+D T+ ++++ +L TL GHE V+ V W+ Sbjct: 277 VKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRL-HTLEGHEDEVYNVQWS- 334 Query: 64 PKFGTILASCSYDGKVLIWKE------------ENGRWSQIAVHAVHSASVNSVQWAPHE 111 P IL + S D +V +W E+G + +H H+ V+ + W P+ Sbjct: 335 PHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPN- 393 Query: 112 YGPLLLVASSDGKVSVV 128 +L + D + + Sbjct: 394 NKWVLASLADDNILQIW 410 Score = 101 bits (251), Expect = 4e-22, Method: Composition-based stats. Identities = 51/255 (20%), Positives = 92/255 (36%), Gaps = 37/255 (14%) Query: 2 VVIANAHNELIHDAVLDYYGK-RLATCSSDKTIKIFEVEGETHKLIDT--------LTGH 52 H ++ + LAT + D +I +++++G++ L + H Sbjct: 175 QACLRHHTSEGFGLGWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRH 234 Query: 53 EGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQ-IAVHAVHSASVNSVQWAPHE 111 V + + H + +L S S D + I S H VN V + P Sbjct: 235 TAVVNDLQF-HLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNP-F 292 Query: 112 YGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESR 171 LL AS+D V++ + + ++ H V + W+P + Sbjct: 293 NDYLLATASADHTVALWDLRR-LNQRLHTLEGHEDEVYNVQWSPH------------DEP 339 Query: 172 KFVTGGADNLVKIWKYN--------SDAQTYVLESTLE--GHSDWVRDVAWSPTVLLRSY 221 VT D V +W + D++ E GH++ V D++W+P Sbjct: 340 ILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKW--V 397 Query: 222 LASVSQDRTCIIWTQ 236 LAS++ D IW+ Sbjct: 398 LASLADDNILQIWSP 412 Score = 56.7 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 33/192 (17%), Positives = 62/192 (32%), Gaps = 18/192 (9%) Query: 98 HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPAT 157 H VN ++ P + ++ +G + + PI+ H + T Sbjct: 130 HEGDVNKARFMP-QNPDIIATLGLNGNGYIFDLN-LYREQPIVQTGHQACLRH-----HT 182 Query: 158 IEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVL------ESTLEGHSDWVRDVA 211 E G + TG D + +W + + S H+ V D+ Sbjct: 183 SEGFGLGWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQ 242 Query: 212 WSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSL-SGNVLA 270 + + + L SVS D T I D + + +++ + +LA Sbjct: 243 FH--LQHEALLTSVSDDCTLQI--HDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLA 298 Query: 271 LSGGDNKVTLWK 282 + D+ V LW Sbjct: 299 TASADHTVALWD 310 >5L9T-R nrPDB Length = 493 Score = 143 bits (359), Expect = 1e-34, Method: Composition-based stats. Identities = 56/245 (22%), Positives = 98/245 (40%), Gaps = 28/245 (11%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 + + H + L + ++L++ S D+ I ++ + L GH V + W Sbjct: 264 LSMLEGHTARV--GALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKW 321 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 + +LAS D K+L+W + S + + H A+V ++ W+PH++G L AS Sbjct: 322 STDHQ--LLASGGNDNKLLVWNHSS--LSPVQQYTEHLAAVKAIAWSPHQHGLL---ASG 374 Query: 122 DGKV-SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 G + F T P+ V + +W+ E H G + N Sbjct: 375 GGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTH-----------GYSQN 423 Query: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 + +WKY S Q + L GHS V +A SP + + + D T W ++ Sbjct: 424 QILVWKYPSLTQ----VAKLTGHSYRVLYLAMSPD---GEAIVTGAGDETLRFWNVFSKT 476 Query: 241 GPWKK 245 K+ Sbjct: 477 RSTKE 481 Score = 103 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 47/274 (17%), Positives = 82/274 (29%), Gaps = 35/274 (12%) Query: 10 ELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTI 69 + + G +A + ++I++ K + L GH V + W + Sbjct: 230 DSVTSVGWSERGNLVAVGTHKGFVQIWDAAA--GKKLSMLEGHTARVGALAWNAEQ---- 283 Query: 70 LASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVE 129 L+S S D +L H V ++W+ LL +D K+ V Sbjct: 284 LSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDH--QLLASGGNDNKLLVW- 340 Query: 130 FKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNS 189 + + H V + +W+P GT AD ++ W + Sbjct: 341 -NHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGT----------ADRCIRFWNTLT 389 Query: 190 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLAS--VSQDRTCIIWTQDNEQGPWKKTL 247 Q T V ++AWS L S ++W P + Sbjct: 390 G-QPLQCIDT----GSQVCNLAWSKHANE---LVSTHGYSQNQILVWKY-----PSLTQV 436 Query: 248 LKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 K + + S G + GD + W Sbjct: 437 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFW 470 Score = 96.4 bits (238), Expect = 1e-20, Method: Composition-based stats. Identities = 49/270 (18%), Positives = 95/270 (35%), Gaps = 37/270 (13%) Query: 17 LDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYD 76 +D+ + + + ++ + L+ V V W+ + G ++A ++ Sbjct: 193 VDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWS--ERGNLVAVGTHK 250 Query: 77 GKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTT 136 G V IW G+ ++++ H+A V ++ W + L S D + + + Sbjct: 251 GFVQIWDAAAGK--KLSMLEGHTARVGALAWNAEQ----LSSGSRDRMILQRDIRTPPLQ 304 Query: 137 SPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVL 196 S + H V W+ + + +GG DN + +W ++S Sbjct: 305 SERRLQGHRQEVCGLKWS-------------TDHQLLASGGNDNKLLVWNHSS----LSP 347 Query: 197 ESTLEGHSDWVRDVAWSPTVLLRSYLASVS--QDRTCIIWTQDNEQGPWKKTLLKEEKFP 254 H V+ +AWSP LAS DR W G + + + Sbjct: 348 VQQYTEHLAAVKAIAWSPHQHG--LLASGGGTADRCIRFWN--TLTGQPLQCIDTGSQ-- 401 Query: 255 DVLWRASWSLSGNVLAL--SGGDNKVTLWK 282 + +WS N L N++ +WK Sbjct: 402 --VCNLAWSKHANELVSTHGYSQNQILVWK 429 Score = 56.4 bits (134), Expect = 1e-08, Method: Composition-based stats. Identities = 39/180 (21%), Positives = 64/180 (35%), Gaps = 29/180 (16%) Query: 102 VNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEED 161 +N V W+ +L V + + T + V S W+ Sbjct: 190 LNLVDWSS----LNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWS------- 238 Query: 162 GEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSY 221 + G V+IW DA S LEGH+ V +AW+ Sbjct: 239 ------ERGNLVAVGTHKGFVQIW----DAAAGKKLSMLEGHTARVGALAWNAEQ----- 283 Query: 222 LASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 L+S S+DR + Q + + P ++ + + + WS +LA G DNK+ +W Sbjct: 284 LSSGSRDRMIL---QRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVW 340 >5NZU-C nrPDB Length = 905 Score = 142 bits (357), Expect = 2e-34, Method: Composition-based stats. Identities = 50/210 (23%), Positives = 81/210 (38%), Gaps = 23/210 (10%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 V + AH++ I + + T S D IK+++ + GH V ++ Sbjct: 92 VHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDK-KWSCSQVFEGHTHYVMQI-V 149 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 +PK AS S D + +W+ G S H VN + + P L+ + Sbjct: 150 INPKDNNQFASASLDRTIKVWQL--GSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGAD 207 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 D V + +++ ++ HA V+ AS+ P +TG D Sbjct: 208 DRLVKIWDYQNKTCVQ--TLEGHAQNVSCASFHPELPI-------------IITGSEDGT 252 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVA 211 V+IW + TY LESTL + V VA Sbjct: 253 VRIW----HSSTYRLESTLNYGMERVWCVA 278 Score = 134 bits (337), Expect = 4e-32, Method: Composition-based stats. Identities = 49/277 (17%), Positives = 104/277 (37%), Gaps = 31/277 (11%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 A ++ + L + + ++ ++ ET L+ T + PV + Sbjct: 11 LTARSDRVKSVDLHPTEPWMLASLYNGSVCVWN--HETQTLVKTFEVCDLPVRAAKFVAR 68 Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 K + + + D ++ + ++ + HS + + P + P +L +S D Sbjct: 69 K--NWVVTGADDMQIRV--FNYNTLERVHMFEAHSDYIRCIAVHPTQ--PFILTSSDDML 122 Query: 125 VSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 + + ++ + + S + + H V P K++ +F + D +K+ Sbjct: 123 IKLWDWDKKWSCSQ-VFEGHTHYVMQIVINP------------KDNNQFASASLDRTIKV 169 Query: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 244 W+ S + + TLEGH V + + + + YL S + DR IW N+ Sbjct: 170 WQLGSSSPNF----TLEGHEKGVNCIDY-YSGGDKPYLISGADDRLVKIWDYQNKT--CV 222 Query: 245 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 +TL E + AS+ ++ D V +W Sbjct: 223 QTL---EGHAQNVSCASFHPELPIIITGSEDGTVRIW 256 Score = 106 bits (264), Expect = 1e-23, Method: Composition-based stats. Identities = 41/208 (19%), Positives = 77/208 (37%), Gaps = 22/208 (10%) Query: 1 MVVIANAHNELIHDAVLDYY-GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRV 59 + H + V++ + A+ S D+TIK++++ + TL GHE V + Sbjct: 134 CSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNF--TLEGHEKGVNCI 191 Query: 60 DWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA 119 D+ L S + D V IW +N Q H+ +V+ + P P+++ Sbjct: 192 DYYSGGDKPYLISGADDRLVKIWDYQNKTCVQ--TLEGHAQNVSCASFHPE--LPIIITG 247 Query: 120 SSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFV----- 174 S DG V + +S +++ W A++ + + Sbjct: 248 SEDGTVRIW------HSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGR 301 Query: 175 ---TGGADNLVK-IWKYNSDAQTYVLES 198 D K IW +S+ Q L++ Sbjct: 302 EEPAMSMDANGKIIWAKHSEVQQANLKA 329 Score = 75.2 bits (183), Expect = 3e-14, Method: Composition-based stats. Identities = 39/206 (18%), Positives = 72/206 (34%), Gaps = 36/206 (17%) Query: 99 SASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATI 158 S V SV P E P +L + +G V V H ++ + Sbjct: 15 SDRVKSVDLHPTE--PWMLASLYNGSVCVWN--------------HETQTLVKTFEVCDL 58 Query: 159 EEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLL 218 +++ VTG D ++++ YN T E HSD++R +A PT Sbjct: 59 PVRAAKFVARKN-WVVTGADDMQIRVFNYN----TLERVHMFEAHSDYIRCIAVHPT--- 110 Query: 219 RSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSL-SGNVLALSGGDNK 277 + ++ + S D +W D ++ + E + + + N A + D Sbjct: 111 QPFILTSSDDMLIKLWDWD-KKWSCSQVF---EGHTHYVMQIVINPKDNNQFASASLDRT 166 Query: 278 VTLWKE-------NLEGKWEPAGEVH 296 + +W+ LEG + + Sbjct: 167 IKVWQLGSSSPNFTLEGHEKGVNCID 192 >6ID0-T nrPDB Length = 514 Score = 140 bits (353), Expect = 5e-34, Method: Composition-based stats. Identities = 55/279 (19%), Positives = 94/279 (33%), Gaps = 37/279 (13%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 + + H + ++ + T S+D+TIKI+++ KL +LTGH V V + Sbjct: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL--SLTGHISTVRGVIVST 256 Query: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 L SC D +V W E + I + H ++V + P +L+ S D Sbjct: 257 --RSPYLFSCGEDKQVKCWDLEYNKV--IRHYHGHLSAVYGLDLHPTI--DVLVTCSRDS 310 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 + + + + + H V + + +TG D ++ Sbjct: 311 TARIWDVRTKASV--HTLSGHTNAVATVRC-------------QAAEPQIITGSHDTTIR 355 Query: 184 IWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPW 243 +W D TL H VR V P AS S D W P Sbjct: 356 LW----DLVAGKTRVTLTNHKKSVRAVVLHPRHY---TFASGSPDN-IKQWK-----FPD 402 Query: 244 KKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 + ++ + + G VL + + LW Sbjct: 403 GSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWD 440 Score = 111 bits (278), Expect = 3e-25, Method: Composition-based stats. Identities = 48/243 (19%), Positives = 73/243 (30%), Gaps = 34/243 (13%) Query: 40 GETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHS 99 KL ++GH G V + + S D + IW +G+ H Sbjct: 191 HPPWKLYRVISGHLGWVRCIAVEP--GNQWFVTGSADRTIKIWDLASGKLK--LSLTGHI 246 Query: 100 ASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIE 159 ++V V + P L D +V + + N H V P Sbjct: 247 STVRGVIVS--TRSPYLFSCGEDKQVKCWDLEYNKVIRHY--HGHLSAVYGLDLHPTI-- 300 Query: 160 EDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLR 219 VT D+ +IW D +T TL GH++ V V Sbjct: 301 -----------DVLVTCSRDSTARIW----DVRTKASVHTLSGHTNAVATVRC---QAAE 342 Query: 220 SYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVT 279 + + S D T +W G + TL +K + A DN + Sbjct: 343 PQIITGSHDTTIRLWDLVA--GKTRVTLTNHKK---SVRAVVLHPRHYTFASGSPDN-IK 396 Query: 280 LWK 282 WK Sbjct: 397 QWK 399 Score = 79.5 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 40/221 (18%), Positives = 85/221 (38%), Gaps = 29/221 (13%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 V + H + ++ T S D TI+++++ ++ TLT H+ V V Sbjct: 323 VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRV--TLTNHKKSVRAVVL 380 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 + AS S D + WK +G + Q + H+A +N++ +L+ + Sbjct: 381 HPRHY--TFASGSPD-NIKQWKFPDGSFIQ--NLSGHNAIINTLTVNSDG---VLVSGAD 432 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 +G + + +++ + ++S S A + + +T AD Sbjct: 433 NGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQS-------ESRLLTAEADKT 485 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYL 222 +K+++ + +T E H V+W P ++ R Sbjct: 486 IKVYREDD-------TATEETHP-----VSWKPEIIKRKRF 514 Score = 57.1 bits (136), Expect = 9e-09, Method: Composition-based stats. Identities = 21/92 (22%), Positives = 30/92 (32%), Gaps = 8/92 (8%) Query: 194 YVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKF 253 + L + GH WVR +A P + + S DRT IW + + T Sbjct: 194 WKLYRVISGHLGWVRCIAVEP---GNQWFVTGSADRTIKIWDLASGKLKLSLT-----GH 245 Query: 254 PDVLWRASWSLSGNVLALSGGDNKVTLWKENL 285 + S L G D +V W Sbjct: 246 ISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEY 277 >6EMK-B nrPDB Length = 303 Score = 139 bits (349), Expect = 2e-33, Method: Composition-based stats. Identities = 58/239 (24%), Positives = 93/239 (38%), Gaps = 23/239 (9%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 V H + + + T S D TIK+++V + I H PV V Sbjct: 68 VASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS---IPRNYKHNAPVNEV-V 123 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 HP G ++ SC DG + IW + + + S+ S+ A G +L A++ Sbjct: 124 IHPNQGELI-SCDRDGNIRIWDLGENQCTHQLTPEDDT-SLQSLSMASD--GSMLAAANT 179 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 G V E N T + + +S + D +H T AD+ Sbjct: 180 KGNCYVWEMP-NHTDASHLKPVTKFRAHSTYITRILLSSDVKH--------LATCSADHT 230 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 ++W + D + LE+TL+GH WV D A+S +YL + S D +W + Sbjct: 231 ARVWSIDDD---FKLETTLDGHQRWVWDCAFSAD---SAYLVTASSDHYVRLWDLSTRE 283 Score = 121 bits (302), Expect = 5e-28, Method: Composition-based stats. Identities = 50/280 (17%), Positives = 101/280 (36%), Gaps = 32/280 (11%) Query: 8 HNEL-IHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H++ ++ + K LAT ++++++ + + GH G V V + + Sbjct: 30 HSDSQVNRLEITNDKKLLATAGHQN-VRLYDIRTTNPNPVASFEGHRGNVTSVSF--QQD 86 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 + + S DG + +W + I + H+A VN V P++ L+ DG + Sbjct: 87 NRWMVTSSEDGTIKVWDVRS---PSIPRNYKHNAPVNEVVIHPNQGE--LISCDRDGNIR 141 Query: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 + + EN T + P + + +W+ Sbjct: 142 IWDLGENQCTHQL--------------TPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE 187 Query: 187 YNS--DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 244 + DA + HS ++ + S V +LA+ S D T +W+ D++ Sbjct: 188 MPNHTDASHLKPVTKFRAHSTYITRILLSSDV---KHLATCSADHTARVWSIDDDF---- 240 Query: 245 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 K + +W ++S L + D+ V LW + Sbjct: 241 KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLS 280 Score = 91.4 bits (225), Expect = 4e-19, Method: Composition-based stats. Identities = 48/276 (17%), Positives = 91/276 (32%), Gaps = 32/276 (11%) Query: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 L + D TI+ +E T T+ + V R++ + K +LA+ + V ++ Sbjct: 5 LVSAGYDHTIRFWE--ALTGVCSRTIQHSDSQVNRLEITNDKK--LLATAGH-QNVRLYD 59 Query: 84 EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDA 143 + +A H +V SV + + ++ +S DG + V + + Sbjct: 60 IRTTNPNPVASFEGHRGNVTSVSFQ--QDNRWMVTSSEDGTIKVWDVRSPSIPRNYK--- 114 Query: 144 HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGH 203 H VN P E ++ D ++IW + L Sbjct: 115 HNAPVNEVVIHPNQGE-------------LISCDRDGNIRIWDLGEN----QCTHQLTPE 157 Query: 204 SDWVR-DVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKE-EKFPDVLWRAS 261 D ++ + S LA+ + C +W N + + + R Sbjct: 158 DDTSLQSLSMASD---GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRIL 214 Query: 262 WSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 S LA D+ +W + + K E + HQ Sbjct: 215 LSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQ 250 >4V8M-A7 nrPDB Length = 318 Score = 136 bits (342), Expect = 1e-32, Method: Composition-based stats. Identities = 54/246 (21%), Positives = 89/246 (36%), Gaps = 38/246 (15%) Query: 49 LTGHEGPVWRVDW-AHPKFGTILASCSYDGKVLIW-------KEENGRWSQIAVHAVHSA 100 LTGH G V + P+ T + S S D +L W E HSA Sbjct: 9 LTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSA 68 Query: 101 SVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEE 160 V+ V + + G + AS D + + + + H V S +++P Sbjct: 69 FVSDVALSNN--GNFAVSASWDHSLRLWNLQNGQCQYKFL--GHTKDVLSVAFSP----- 119 Query: 161 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLE--GHSDWVRDVAWSPTVLL 218 ++R+ V+GG DN +++W TL H+DWV V +SP+ L Sbjct: 120 --------DNRQIVSGGRDNALRVWNV-----KGECMHTLSRGAHTDWVSCVRFSPS-LD 165 Query: 219 RSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKV 278 + S D +W + + + + + + S G++ A S D Sbjct: 166 APVIVSGGWDNLVKVWDLATGR-----LVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVA 220 Query: 279 TLWKEN 284 LW Sbjct: 221 RLWDLT 226 Score = 131 bits (328), Expect = 5e-31, Method: Composition-based stats. Identities = 41/279 (14%), Positives = 92/279 (32%), Gaps = 31/279 (11%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 H+ + D L G + S D +++++ ++ + GH V V ++ Sbjct: 63 LEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQN--GQCQYKFLGHTKDVLSVAFSPD 120 Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 + S D + +W + G H+ V+ V+++P P+++ D Sbjct: 121 N--RQIVSGGRDNALRVWNVK-GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNL 177 Query: 125 VSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 V V + + + H V S + +P + + D + ++ Sbjct: 178 VKVWDLATGRLVTD--LKGHTNYVTSVTVSP-------------DGSLCASSDKDGVARL 222 Query: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ--GP 242 W + + + + +SP Y + ++ I+ +N+ Sbjct: 223 WDLTKGEALSEMAAG-----APINQICFSPN----RYWMCAATEKGIRIFDLENKDIIVE 273 Query: 243 WKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 +K +WS G+ L DN + +W Sbjct: 274 LAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVW 312 Score = 117 bits (293), Expect = 6e-27, Method: Composition-based stats. Identities = 42/234 (17%), Positives = 83/234 (35%), Gaps = 32/234 (13%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLT--GHEGPVWRVDWAHP 64 H + + +++ + D ++++ V+GE + TL+ H V V ++ Sbjct: 107 GHTKDVLSVAFSPDNRQIVSGGRDNALRVWNVKGE---CMHTLSRGAHTDWVSCVRFSPS 163 Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 ++ S +D V +W GR + H+ V SV +P G L + DG Sbjct: 164 LDAPVIVSGGWDNLVKVWDLATGRL--VTDLKGHTNYVTSVTVSPD--GSLCASSDKDGV 219 Query: 125 VSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 + + + S + A +N ++P +R ++ + ++I Sbjct: 220 ARLWDLTKGEALSEM---AAGAPINQICFSP--------------NRYWMCAATEKGIRI 262 Query: 185 WKYNSDAQTYVLESTLEGHSDWVR---DVAWSPTVLLRSYLASVSQDRTCIIWT 235 + + L +G V +AWS S L S D +W Sbjct: 263 FDLENKDIIVELAPEHQGSKKIVPECVSIAWSAD---GSTLYSGYTDNVIRVWG 313 Score = 51.0 bits (120), Expect = 7e-07, Method: Composition-based stats. Identities = 20/89 (22%), Positives = 38/89 (42%), Gaps = 4/89 (4%) Query: 197 ESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTL----LKEEK 252 E L GH WV +A T + + S S+D+T + W + ++ + + + E Sbjct: 6 EGQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEG 65 Query: 253 FPDVLWRASWSLSGNVLALSGGDNKVTLW 281 + + S +GN + D+ + LW Sbjct: 66 HSAFVSDVALSNNGNFAVSASWDHSLRLW 94 Score = 45.2 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 19/137 (13%), Positives = 42/137 (30%), Gaps = 9/137 (6%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 +V H + + G A+ D +++++ + + + P+ ++ Sbjct: 188 LVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLT--KGEALSEMAA-GAPINQIC 244 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRW--SQIAVHAVHSASV-NSVQWAPHEYGPLLL 117 ++ + + + I+ EN H V V A G L Sbjct: 245 FSP---NRYWMCAATEKGIRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLY 301 Query: 118 VASSDGKVSVVEFKENG 134 +D + V EN Sbjct: 302 SGYTDNVIRVWGVSENA 318 >3MKQ-A nrPDB Length = 814 Score = 135 bits (339), Expect = 3e-32, Method: Composition-based stats. Identities = 56/270 (20%), Positives = 87/270 (32%), Gaps = 32/270 (11%) Query: 9 NELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGT 68 + + S D I++F T + + H + + HP Sbjct: 55 ETPVRAGKFIARKNWIIVGSDDFRIRVFNY--NTGEKVVDFEAHPDYIRSIA-VHPTKP- 110 Query: 69 ILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 + S S D V +W EN W+ H V V + P + D V V Sbjct: 111 YVLSGSDDLTVKLWNWENN-WALEQTFEGHEHFVMCVAFNPKDPST-FASGCLDRTVKVW 168 Query: 129 EFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN 188 ++ + GVN + P + +T D +KIW Y Sbjct: 169 SLGQSTPNFTLT-TGQERGVNYVDYYPL-----------PDKPYMITASDDLTIKIWDY- 215 Query: 189 SDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLL 248 QT +TLEGH V + PT+ + S S+D T IW +KTL Sbjct: 216 ---QTKSCVATLEGHMSNVSFAVFHPTL---PIIISGSEDGTLKIWNS--STYKVEKTLN 267 Query: 249 KEEKFPDVLWRASWSLSG--NVLALSGGDN 276 + W + +G N +A + Sbjct: 268 VG---LERSWCIATHPTGRKNYIASGFDNG 294 Score = 127 bits (318), Expect = 7e-30, Method: Composition-based stats. Identities = 59/294 (20%), Positives = 107/294 (36%), Gaps = 42/294 (14%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 VV AH + I + + + S D T+K++ E L T GHE V V + Sbjct: 90 VVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENN-WALEQTFEGHEHFVMCVAF 148 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 +PK + AS D V +W + VN V + P P ++ AS Sbjct: 149 -NPKDPSTFASGCLDRTVKVWSL-GQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASD 206 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 D + + +++ + ++ H V+ A + P ++G D Sbjct: 207 DLTIKIWDYQTKSCVA--TLEGHMSNVSFAVFHPTLPI-------------IISGSEDGT 251 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQG 241 +KIW ++ TY +E TL + +A PT ++Y+AS D + + N++ Sbjct: 252 LKIW----NSSTYKVEKTLNVGLERSWCIATHPTGR-KNYIAS-GFDNGFTVLSLGNDEP 305 Query: 242 PWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVT-LWKENLEGKWEPAGE 294 S G ++ G + + ++ + G E + Sbjct: 306 -----------------TLSLDPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQD 342 Score = 114 bits (284), Expect = 6e-26, Method: Composition-based stats. Identities = 46/278 (16%), Positives = 92/278 (33%), Gaps = 30/278 (10%) Query: 9 NELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGT 68 ++ + + T ++I+ ET + ++ E PV + K Sbjct: 13 SDRVKGIDFHPTEPWVLTTLYSGRVEIWNY--ETQVEVRSIQVTETPVRAGKFIARK--N 68 Query: 69 ILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 + S D ++ ++ G ++ H + S+ P + P +L S D V + Sbjct: 69 WIIVGSDDFRIRVFNYNTGE--KVVDFEAHPDYIRSIAVHPTK--PYVLSGSDDLTVKLW 124 Query: 129 EFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN 188 ++ N + H V ++ P K+ F +G D VK+W Sbjct: 125 NWENNWALEQ-TFEGHEHFVMCVAFNP------------KDPSTFASGCLDRTVKVWSLG 171 Query: 189 SDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLL 248 + L G V V + P + + Y+ + S D T IW K + Sbjct: 172 QSTPNFTLT---TGQERGVNYVDYYP-LPDKPYMITASDDLTIKIWDY-----QTKSCVA 222 Query: 249 KEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLE 286 E + A + + ++ D + +W + Sbjct: 223 TLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTY 260 Score = 90.3 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 47/243 (19%), Positives = 85/243 (34%), Gaps = 32/243 (13%) Query: 42 THKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSAS 101 + T + V +D+ HP +L + Y G+V IW E ++ V Sbjct: 2 KLDIKKTFSNRSDRVKGIDF-HPTEPWVLTTL-YSGRVEIWNYETQ--VEVRSIQVTETP 57 Query: 102 VNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEED 161 V + ++ ++V S D ++ V + +AH + S + P Sbjct: 58 VRAGKFI--ARKNWIIVGSDDFRIRVFNYNTGEKVVDF--EAHPDYIRSIAVHPTKP--- 110 Query: 162 GEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSY 221 ++G D VK+W + ++ + LE T EGH +V VA++P S Sbjct: 111 ----------YVLSGSDDLTVKLWNWENN---WALEQTFEGHEHFVMCVAFNPKDP--ST 155 Query: 222 LASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSL--SGNVLALSGGDNKVT 279 AS DRT +W+ G + + + + D + Sbjct: 156 FASGCLDRTVKVWSL----GQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIK 211 Query: 280 LWK 282 +W Sbjct: 212 IWD 214 Score = 44.0 bits (102), Expect = 7e-05, Method: Composition-based stats. Identities = 31/186 (16%), Positives = 57/186 (30%), Gaps = 22/186 (11%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 V H + AV + + S D T+KI+ T+K+ TL W + Sbjct: 220 CVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWN--SSTYKVEKTLNVGLERSWCIA 277 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 +AS +D + N + V + W+ G AS Sbjct: 278 THPTGRKNYIASG-FDNGFTVLSLGNDEPTLSL------DPVGKLVWS----GGKNAAAS 326 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 + +E P+ + +G +++ + + +FVT D Sbjct: 327 DIFTAVIRGNEEVEQDEPLSLQTKELG---------SVDVFPQSLAHSPNGRFVTVVGDG 377 Query: 181 LVKIWK 186 I+ Sbjct: 378 EYVIYT 383 >5FVM-C nrPDB Length = 303 Score = 134 bits (338), Expect = 3e-32, Method: Composition-based stats. Identities = 51/244 (20%), Positives = 93/244 (38%), Gaps = 33/244 (13%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 V H + + + + S D TIK+++V + + H PV V Sbjct: 68 VSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPS---VQRNYKHNAPVNEVA- 123 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 HP G ++ SC DG + IW + + ++ + S+ A G +L+ ++ Sbjct: 124 IHPNQGELI-SCDQDGNIRIWDLGENQCTNQLTPEDNT-PLQSLSVASD--GSMLVAGNN 179 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTK-----ESRKFVTG 176 G V + H ++++ P T + T+ + + T Sbjct: 180 KGNCYVWR-----------MPHHT---DASTLEPVTKFKSHTKYITRVLLSADVKNLATC 225 Query: 177 GADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ 236 AD+ ++W + Y LE+TL+GH WV D A+S +YL + D +W Sbjct: 226 SADHTARVWNIEDN---YQLETTLDGHQRWVWDCAFSAD---SAYLVTACSDHYVRLWDL 279 Query: 237 DNEQ 240 + Sbjct: 280 STSE 283 Score = 123 bits (309), Expect = 8e-29, Method: Composition-based stats. Identities = 48/278 (17%), Positives = 101/278 (36%), Gaps = 31/278 (11%) Query: 9 NELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGT 68 + ++ + K LA ++++++ + + GH+G V + + + Sbjct: 32 DSQVNRLEITSDKKYLAAAGH-LHVRLYDIRSNNPNPVSSFEGHKGNVTSIAF--QQENR 88 Query: 69 ILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 + S S DG + +W + + + H+A VN V P++ L+ DG + + Sbjct: 89 WMVSSSEDGTIKVWDVRS---PSVQRNYKHNAPVNEVAIHPNQGE--LISCDQDGNIRIW 143 Query: 129 EFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN 188 + EN T+ + P + + V G +W+ Sbjct: 144 DLGENQCTNQL--------------TPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWRMP 189 Query: 189 --SDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT 246 +DA T + + H+ ++ V S V LA+ S D T +W ++ + Sbjct: 190 HHTDASTLEPVTKFKSHTKYITRVLLSADVKN---LATCSADHTARVWNIEDNY----QL 242 Query: 247 LLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 + +W ++S L + D+ V LW + Sbjct: 243 ETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLS 280 Score = 83.7 bits (205), Expect = 9e-17, Method: Composition-based stats. Identities = 45/214 (21%), Positives = 73/214 (34%), Gaps = 30/214 (14%) Query: 69 ILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 ILAS YD + W+ G S+ HA + VN ++ L A+ V + Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHA--DSQVNRLEITSD---KKYLAAAGHLHVRLY 58 Query: 129 EFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN 188 + + N + H V S ++ +E+R V+ D +K+W Sbjct: 59 DIRSNNPNPVSSFEGHKGNVTSIAF-------------QQENRWMVSSSEDGTIKVWDVR 105 Query: 189 SDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLL 248 S + + H+ V +VA P L S QD IW Q + T Sbjct: 106 SPSVQRNYK-----HNAPVNEVAIHPNQGE---LISCDQDGNIRIWDLGENQCTNQLTPE 157 Query: 249 KEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 L S + G++L +W+ Sbjct: 158 DNT----PLQSLSVASDGSMLVAGNNKGNCYVWR 187 Score = 82.6 bits (202), Expect = 2e-16, Method: Composition-based stats. Identities = 45/274 (16%), Positives = 91/274 (33%), Gaps = 32/274 (11%) Query: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 LA+ D TI+ +E T T+ + V R++ K LA+ + V ++ Sbjct: 5 LASAGYDHTIRFWE--ALTGVCSRTIQHADSQVNRLEITSDKK--YLAAAGH-LHVRLYD 59 Query: 84 EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDA 143 + + ++ H +V S+ + + ++ +S DG + V + + Sbjct: 60 IRSNNPNPVSSFEGHKGNVTSIAFQ--QENRWMVSSSEDGTIKVWDVRSPSVQRNYK--- 114 Query: 144 HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGH 203 H VN + P E ++ D ++IW + T L Sbjct: 115 HNAPVNEVAIHPNQGE-------------LISCDQDGNIRIWDLGENQCTNQLTP----- 156 Query: 204 SDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKE-EKFPDVLWRASW 262 D + S S L + + C +W + + + + + R Sbjct: 157 EDNTPLQSLS-VASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLL 215 Query: 263 SLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVH 296 S LA D+ +W N+E ++ + Sbjct: 216 SADVKNLATCSADHTARVW--NIEDNYQLETTLD 247 >6EOJ-D nrPDB Length = 470 Score = 132 bits (331), Expect = 2e-31, Method: Composition-based stats. Identities = 51/232 (21%), Positives = 86/232 (37%), Gaps = 25/232 (10%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 I AH E I D + TCS D +KI+ + L+GH V DW H Sbjct: 172 IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE--RVLSGHHWDVKSCDW-H 228 Query: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 P+ G ++AS S D V +W +G + H+ V ++ P + G LL+ S D Sbjct: 229 PEMG-LIASASKDNLVKLWDPRSGNCISSILKFKHT--VLKTRFQPTK-GNLLMAISKDK 284 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 V + + + ++ + W P F D +K Sbjct: 285 SCRVFDIRYSM--KELMCVRDETDYMTLEWHPINESM------------FTLACYDGSLK 330 Query: 184 IWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 + + +L H + ++++P + A+ ++DRT WT Sbjct: 331 HFDLLQNLNEPILTIPY-AHDKCITSLSYNP---VGHIFATAAKDRTIRFWT 378 Score = 109 bits (273), Expect = 1e-24, Method: Composition-based stats. Identities = 45/279 (16%), Positives = 91/279 (32%), Gaps = 30/279 (10%) Query: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 + AH+ + + + + +D IKI++ K ID H + + ++ Sbjct: 129 TLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDA--AHTESIRDMAFS 186 Query: 63 HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD 122 +CS D + IW NG+ ++ + H V S W P L+ AS D Sbjct: 187 SNDSK--FVTCSDDNILKIWNFSNGKQERV--LSGHHWDVKSCDWHPE--MGLIASASKD 240 Query: 123 GKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLV 182 V + + + S I+ H V + P + + D Sbjct: 241 NLVKLWDPRSGNCISSILKFKHT--VLKTRFQP------------TKGNLLMAISKDKSC 286 Query: 183 KIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGP 242 +++ + + +D++ + W P LA D + + Sbjct: 287 RVFDIRYSMKELMCVRD---ETDYM-TLEWHPINESMFTLAC--YDGSLKHFDLLQNLNE 340 Query: 243 WKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 T+ + S++ G++ A + D + W Sbjct: 341 PILTI--PYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 84.1 bits (206), Expect = 8e-17, Method: Composition-based stats. Identities = 41/184 (22%), Positives = 75/184 (40%), Gaps = 29/184 (15%) Query: 99 SASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATI 158 + ++QW P G L+VA+ G+ S+ + T ++ AH V + ++ Sbjct: 93 KHVIPAIQWTPE--GRRLVVATYSGEFSLW--NASSFTFETLMQAHDSAVTTMKYS---- 144 Query: 159 EEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLL 218 +S ++G AD ++KIW+ N +++ H++ +RD+A+S Sbjct: 145 ---------HDSDWMISGDADGMIKIWQPN----FSMVKEIDAAHTESIRDMAFSSND-- 189 Query: 219 RSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKV 278 S + S D IW N G ++ L + W ++A + DN V Sbjct: 190 -SKFVTCSDDNILKIWNFSN--GKQERVLSGHHW---DVKSCDWHPEMGLIASASKDNLV 243 Query: 279 TLWK 282 LW Sbjct: 244 KLWD 247 Score = 38.3 bits (87), Expect = 0.004, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 19/36 (52%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIF 36 ++ I AH++ I + G AT + D+TI+ + Sbjct: 342 ILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 34.8 bits (78), Expect = 0.043, Method: Composition-based stats. Identities = 8/79 (10%), Positives = 21/79 (26%), Gaps = 8/79 (10%) Query: 207 VRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSG 266 + + W+P L + +W + + +S Sbjct: 96 IPAIQWTPE---GRRLVVATYSGEFSLWNASSFTFETLMQ-----AHDSAVTTMKYSHDS 147 Query: 267 NVLALSGGDNKVTLWKENL 285 + + D + +W+ N Sbjct: 148 DWMISGDADGMIKIWQPNF 166 >6HHQ-h nrPDB Length = 319 Score = 131 bits (329), Expect = 3e-31, Method: Composition-based stats. Identities = 51/249 (20%), Positives = 78/249 (31%), Gaps = 34/249 (13%) Query: 39 EGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWS---QIAVH 95 E L TL GH G V + +L S S D ++ WK + Sbjct: 3 SNEVLVLRGTLEGHNGWVTSLA-TSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSF 61 Query: 96 AVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAP 155 HS V G L AS D + + + T + H V S Sbjct: 62 KGHSHIVQDCTLTAD--GAYALSASWDKTLRLWDVATGETYQRFV--GHKSDVMSVDID- 116 Query: 156 ATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPT 215 K++ ++G D +K+W +TL GH+DWV V P Sbjct: 117 ------------KKASMIISGSRDKTIKVWTI-----KGQCLATLLGHNDWVSQVRVVPN 159 Query: 216 VLLRS---YLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALS 272 + S D+ W + Q + + S G ++A + Sbjct: 160 EKADDDSVTIISAGNDKMVKAWNLNQFQIEADFI-----GHNSNINTLTASPDGTLIASA 214 Query: 273 GGDNKVTLW 281 G D ++ LW Sbjct: 215 GKDGEIMLW 223 Score = 123 bits (308), Expect = 9e-29, Method: Composition-based stats. Identities = 54/284 (19%), Positives = 105/284 (36%), Gaps = 38/284 (13%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 H+ ++ D L G + S DKT+++++V T + GH+ V VD K Sbjct: 62 KGHSHIVQDCTLTADGAYALSASWDKTLRLWDVA--TGETYQRFVGHKSDVMSVDI--DK 117 Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGP----LLLVASS 121 +++ S S D + +W + +A H+ V+ V+ P+E ++ A + Sbjct: 118 KASMIISGSRDKTIKVWTIKG---QCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGN 174 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 D V + + I H +N+ + +P + + G D Sbjct: 175 DKMVKAWNLNQFQIEADFI--GHNSNINTLTASP-------------DGTLIASAGKDGE 219 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ- 240 + +W + Y L + D V +A+SP +LA+ + +++ D + Sbjct: 220 IMLWNLAAKKAMYTLSA-----QDEVFSLAFSPNRY---WLAAATATG-IKVFSLDPQYL 270 Query: 241 -GPWKKTLLKEEK-FPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 + K +WS G L DN + +W+ Sbjct: 271 VDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQ 314 Score = 107 bits (267), Expect = 6e-24, Method: Composition-based stats. Identities = 53/273 (19%), Positives = 97/273 (35%), Gaps = 33/273 (12%) Query: 4 IANAHNELIHDAVLDY-YGKRLATCSSDKTIKIFEVEGETHKL---IDTLTGHEGPVWRV 59 HN + L + S DKT+ +++ G+ K + + GH V Sbjct: 12 TLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDC 71 Query: 60 DWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA 119 G S S+D + +W G Q H + V SV + +++ Sbjct: 72 TLTAD--GAYALSASWDKTLRLWDVATGETYQR--FVGHKSDVMSVDI--DKKASMIISG 125 Query: 120 SSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGAD 179 S D + V K + H V+ P +D +S ++ G D Sbjct: 126 SRDKTIKVWTIKGQCLA---TLLGHNDWVSQVRVVPNEKADD-------DSVTIISAGND 175 Query: 180 NLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNE 239 +VK W N + +E+ GH+ + + SP + +AS +D ++W + Sbjct: 176 KMVKAWNLNQ----FQIEADFIGHNSNINTLTASPD---GTLIASAGKDGEIMLWNLAAK 228 Query: 240 QGPWKKTLLKEEKFPDVLWRASWSLSGNVLALS 272 + TL D ++ ++S + LA + Sbjct: 229 K--AMYTLSA----QDEVFSLAFSPNRYWLAAA 255 Score = 99.1 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 42/242 (17%), Positives = 82/242 (33%), Gaps = 35/242 (14%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH--- 63 H + +D + + S DKTIK++ ++G + + TL GH V +V Sbjct: 105 GHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKG---QCLATLLGHNDWVSQVRVVPNEK 161 Query: 64 -PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD 122 + S D V W ++ A H++++N++ +P G L+ A D Sbjct: 162 ADDDSVTIISAGNDKMVKAWNL--NQFQIEADFIGHNSNINTLTASPD--GTLIASAGKD 217 Query: 123 GKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLV 182 G++ + + V S +++P +R ++ + Sbjct: 218 GEIMLWNLAAKKAMYTLSAQD---EVFSLAFSP--------------NRYWLAAATATGI 260 Query: 183 KIWKYNSDAQTYVLESTLEGHSDWVR----DVAWSPTVLLRSYLASVSQDRTCIIWTQDN 238 K++ + L G+S +AWS L + D +W Sbjct: 261 KVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSAD---GQTLFAGYTDNVIRVWQVMT 317 Query: 239 EQ 240 Sbjct: 318 AN 319 Score = 71.0 bits (172), Expect = 6e-13, Method: Composition-based stats. Identities = 37/194 (19%), Positives = 60/194 (30%), Gaps = 24/194 (12%) Query: 94 VHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASW 153 H+ V S+ LLL AS D + + + GV S+ Sbjct: 12 TLEGHNGWVTSLA-TSAGQPNLLLSASRDKTLISWKLTGDDQ---------KFGVPVRSF 61 Query: 154 APATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWS 213 + + T + ++ D +++W D T GH V V Sbjct: 62 KGHS-HIVQDCTLTADGAYALSASWDKTLRLW----DVATGETYQRFVGHKSDVMSVDID 116 Query: 214 PTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSL---SGNVLA 270 S + S S+D+T +WT +G TLL + + + Sbjct: 117 ---KKASMIISGSRDKTIKVWTI---KGQCLATLLGHNDWVSQVRVVPNEKADDDSVTII 170 Query: 271 LSGGDNKVTLWKEN 284 +G D V W N Sbjct: 171 SAGNDKMVKAWNLN 184 Score = 56.4 bits (134), Expect = 1e-08, Method: Composition-based stats. Identities = 22/91 (24%), Positives = 38/91 (41%), Gaps = 2/91 (2%) Query: 192 QTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEE 251 + VL TLEGH+ WV +A S + L S S+D+T I W + + + + Sbjct: 5 EVLVLRGTLEGHNGWVTSLATSAGQP--NLLLSASRDKTLISWKLTGDDQKFGVPVRSFK 62 Query: 252 KFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 ++ + + G + D + LW Sbjct: 63 GHSHIVQDCTLTADGAYALSASWDKTLRLWD 93 >5OPT-p nrPDB Length = 318 Score = 131 bits (329), Expect = 4e-31, Method: Composition-based stats. Identities = 54/248 (21%), Positives = 89/248 (35%), Gaps = 42/248 (16%) Query: 49 LTGHEGPVWRVDWAHPKFGTI---LASCSYDGKVLIW-------KEENGRWSQIAVHAVH 98 L GH G V + A P+ S S D ++ W EE H Sbjct: 9 LKGHRGWVTAL--ACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGH 66 Query: 99 SASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATI 158 SA V+ V + + G + AS D + + + + H V S +++P Sbjct: 67 SAFVSDVALSNN--GDFAVSASWDHSLRLWNLQTGVCQHKFL--GHTKDVLSVTFSP--- 119 Query: 159 EEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLE--GHSDWVRDVAWSPTV 216 ++R+ V+GG DN +++W TL H+DWV V +SP+ Sbjct: 120 ----------DNRQIVSGGRDNALRVWNV-----KGECLHTLGRGAHTDWVSCVRFSPS- 163 Query: 217 LLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDN 276 L + S D +W + + L + + + + S G++ A S D Sbjct: 164 LETPLIVSGGWDNLVKVWDIASGR-----LLTDLKGHTNYITSVTVSPDGSLCASSDKDG 218 Query: 277 KVTLWKEN 284 LW Sbjct: 219 VARLWDLT 226 Score = 130 bits (327), Expect = 6e-31, Method: Composition-based stats. Identities = 43/279 (15%), Positives = 93/279 (33%), Gaps = 31/279 (11%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 H+ + D L G + S D +++++ + +T GH V V ++ Sbjct: 63 LEGHSAFVSDVALSNNGDFAVSASWDHSLRLWNL--QTGVCQHKFLGHTKDVLSVTFSPD 120 Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 + S D + +W + G H+ V+ V+++P PL++ D Sbjct: 121 N--RQIVSGGRDNALRVWNVK-GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNL 177 Query: 125 VSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 V V + + + H + S + +P + + D + ++ Sbjct: 178 VKVWDIASGRLLTD--LKGHTNYITSVTVSP-------------DGSLCASSDKDGVARL 222 Query: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ--GP 242 W + + + + +SP Y + ++ I+ +N+ Sbjct: 223 WDLTKGEALSEMAAG-----APINQICFSPN----RYWMCAATEKGIRIFDLENKDVIVE 273 Query: 243 WKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 ++ K +WS GN L DN + +W Sbjct: 274 LAPEAQQKSKKTPECMSIAWSADGNTLYSGYTDNVIRVW 312 Score = 101 bits (250), Expect = 5e-22, Method: Composition-based stats. Identities = 33/221 (14%), Positives = 72/221 (32%), Gaps = 47/221 (21%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLT--GHEGPVWRVDWAHP 64 H + + +++ + D ++++ V+GE + TL H V V ++ Sbjct: 107 GHTKDVLSVTFSPDNRQIVSGGRDNALRVWNVKGE---CLHTLGRGAHTDWVSCVRFSPS 163 Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 ++ S +D V +W +GR + H+ + SV +P G L + DG Sbjct: 164 LETPLIVSGGWDNLVKVWDIASGRL--LTDLKGHTNYITSVTVSPD--GSLCASSDKDGV 219 Query: 125 VSVVEFKENGTTSPIIIDAHAIGVNSASWAPATI-------------------------- 158 + + + S + A +N ++P Sbjct: 220 ARLWDLTKGEALSEM---AAGAPINQICFSPNRYWMCAATEKGIRIFDLENKDVIVELAP 276 Query: 159 ---------EEDGEHNGTKESRKFVTGGADNLVKIWKYNSD 190 E + + +G DN++++W + Sbjct: 277 EAQQKSKKTPECMSIAWSADGNTLYSGYTDNVIRVWSVSEH 317 Score = 46.0 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 19/89 (21%), Positives = 34/89 (38%), Gaps = 4/89 (4%) Query: 197 ESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTL----LKEEK 252 E L+GH WV +A S S+D T I W + ++ + + E Sbjct: 6 EGQLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEG 65 Query: 253 FPDVLWRASWSLSGNVLALSGGDNKVTLW 281 + + S +G+ + D+ + LW Sbjct: 66 HSAFVSDVALSNNGDFAVSASWDHSLRLW 94 >2YNP-A nrPDB Length = 604 Score = 131 bits (328), Expect = 4e-31, Method: Composition-based stats. Identities = 56/270 (20%), Positives = 87/270 (32%), Gaps = 32/270 (11%) Query: 9 NELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGT 68 + + S D I++F T + + H + + HP Sbjct: 55 ETPVRAGKFIARKNWIIVGSDDFRIRVFNY--NTGEKVVDFEAHPDYIRSIA-VHPTKP- 110 Query: 69 ILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 + S S D V +W EN W+ H V V + P + D V V Sbjct: 111 YVLSGSDDLTVKLWNWENN-WALEQTFEGHEHFVMCVAFNPKDPST-FASGCLDRTVKVW 168 Query: 129 EFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN 188 ++ + GVN + P + +T D +KIW Y Sbjct: 169 SLGQSTPNFTLT-TGQERGVNYVDYYPL-----------PDKPYMITASDDLTIKIWDY- 215 Query: 189 SDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLL 248 QT +TLEGH V + PT+ + S S+D T IW +KTL Sbjct: 216 ---QTKSCVATLEGHMSNVSFAVFHPTL---PIIISGSEDGTLKIWNS--STYKVEKTLN 267 Query: 249 KEEKFPDVLWRASWSLSG--NVLALSGGDN 276 + W + +G N +A + Sbjct: 268 VG---LERSWCIATHPTGRKNYIASGFDNG 294 Score = 123 bits (308), Expect = 9e-29, Method: Composition-based stats. Identities = 52/224 (23%), Positives = 88/224 (39%), Gaps = 23/224 (10%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 VV AH + I + + + S D T+K++ E L T GHE V V + Sbjct: 90 VVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENN-WALEQTFEGHEHFVMCVAF 148 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 +PK + AS D V +W + VN V + P P ++ AS Sbjct: 149 -NPKDPSTFASGCLDRTVKVWSL-GQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASD 206 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 D + + +++ + ++ H V+ A + P ++G D Sbjct: 207 DLTIKIWDYQTKSCVA--TLEGHMSNVSFAVFHPTLPI-------------IISGSEDGT 251 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASV 225 +KIW ++ TY +E TL + +A PT ++Y+AS Sbjct: 252 LKIW----NSSTYKVEKTLNVGLERSWCIATHPTGR-KNYIASG 290 Score = 110 bits (275), Expect = 7e-25, Method: Composition-based stats. Identities = 45/278 (16%), Positives = 92/278 (33%), Gaps = 30/278 (10%) Query: 9 NELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGT 68 ++ + + T ++++ ET + ++ E PV + K Sbjct: 13 SDRVKGIDFHPTEPWVLTTLYSGRVELWNY--ETQVEVRSIQVTETPVRAGKFIARK--N 68 Query: 69 ILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 + S D ++ ++ G ++ H + S+ P + P +L S D V + Sbjct: 69 WIIVGSDDFRIRVFNYNTGE--KVVDFEAHPDYIRSIAVHPTK--PYVLSGSDDLTVKLW 124 Query: 129 EFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN 188 ++ N + H V ++ P K+ F +G D VK+W Sbjct: 125 NWENNWALEQ-TFEGHEHFVMCVAFNP------------KDPSTFASGCLDRTVKVWSLG 171 Query: 189 SDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLL 248 + L G V V + P + + Y+ + S D T IW K + Sbjct: 172 QSTPNFTLT---TGQERGVNYVDYYP-LPDKPYMITASDDLTIKIWDY-----QTKSCVA 222 Query: 249 KEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLE 286 E + A + + ++ D + +W + Sbjct: 223 TLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTY 260 Score = 87.2 bits (214), Expect = 8e-18, Method: Composition-based stats. Identities = 48/241 (19%), Positives = 88/241 (36%), Gaps = 28/241 (11%) Query: 42 THKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSAS 101 + T + V +D+ HP +L + Y G+V +W E ++ V Sbjct: 2 KLDIKKTFSNRSDRVKGIDF-HPTEPWVLTTL-YSGRVELWNYETQ--VEVRSIQVTETP 57 Query: 102 VNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEED 161 V + ++ ++V S D ++ V + +AH + S + P Sbjct: 58 VRAGKFI--ARKNWIIVGSDDFRIRVFNYNTGEKVVDF--EAHPDYIRSIAVHPTKP--- 110 Query: 162 GEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSY 221 ++G D VK+W + ++ + LE T EGH +V VA++P S Sbjct: 111 ----------YVLSGSDDLTVKLWNWENN---WALEQTFEGHEHFVMCVAFNPKDP--ST 155 Query: 222 LASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 AS DRT +W+ + T +E V + + + D + +W Sbjct: 156 FASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYP--LPDKPYMITASDDLTIKIW 213 Query: 282 K 282 Sbjct: 214 D 214 Score = 42.9 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 31/186 (16%), Positives = 57/186 (30%), Gaps = 22/186 (11%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 V H + AV + + S D T+KI+ T+K+ TL W + Sbjct: 220 CVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWN--SSTYKVEKTLNVGLERSWCIA 277 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 +AS +D + N + V + W+ G AS Sbjct: 278 THPTGRKNYIASG-FDNGFTVLSLGNDEPTLSL------DPVGKLVWS----GGKNAAAS 326 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 + +E P+ + +G +++ + + +FVT D Sbjct: 327 DIFTAVIRGNEEVEQDEPLSLQTKELG---------SVDVFPQSLAHSPNGRFVTVVGDG 377 Query: 181 LVKIWK 186 I+ Sbjct: 378 EYVIYT 383 >3JAP-g nrPDB Length = 326 Score = 128 bits (322), Expect = 2e-30, Method: Composition-based stats. Identities = 48/247 (19%), Positives = 85/247 (34%), Gaps = 36/247 (14%) Query: 45 LIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWS---QIAVHAVHSAS 101 L TL GH G V + +L S S D ++ W+ + + HS Sbjct: 10 LRGTLEGHNGWVTSLS-TSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHI 68 Query: 102 VNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEED 161 V V + G + AS D + + + + + H V S + Sbjct: 69 VQDVVVSAD--GNYAVSASWDKTLRLWNLATGNSEARFV--GHTGDVLSVAID------- 117 Query: 162 GEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVL---- 217 S K ++ D +++W D L GH+DWV V +P L Sbjct: 118 ------ANSSKIISASRDKTIRVWNTVGD-----CAYVLLGHTDWVTKVRVAPKNLEDGE 166 Query: 218 ---LRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGG 274 R S D+ W+ + + + + + +V+ S G++ A +G Sbjct: 167 VDDGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQP---SPDGSLAASAGK 223 Query: 275 DNKVTLW 281 D ++ +W Sbjct: 224 DGQIYVW 230 Score = 113 bits (282), Expect = 1e-25, Method: Composition-based stats. Identities = 51/288 (17%), Positives = 90/288 (31%), Gaps = 40/288 (13%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 H+ ++ D V+ G + S DKT++++ + T GH G V V Sbjct: 63 KGHSHIVQDVVVSADGNYAVSASWDKTLRLWNLA--TGNSEARFVGHTGDVLSVAI--DA 118 Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGP--------LLL 117 + + S S D + +W V H+ V V+ AP + Sbjct: 119 NSSKIISASRDKTIRVWNTVG---DCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFV 175 Query: 118 VASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGG 177 A D V E+ H +N + + + G Sbjct: 176 SAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVV-------------QPSPDGSLAASAG 222 Query: 178 ADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQD 237 D + +W + ++ D V +A+SP+ + + + I+ + Sbjct: 223 KDGQIYVWNLKHKSAFMNFDAK-----DEVFALAFSPS----RFWLTAATASGIKIYDLE 273 Query: 238 NEQ--GPWKKTLLKEEKFPD-VLWRASWSLSGNVLALSGGDNKVTLWK 282 NE K K D +WS G L DN + +W+ Sbjct: 274 NEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQ 321 Score = 110 bits (275), Expect = 7e-25, Method: Composition-based stats. Identities = 55/283 (19%), Positives = 100/283 (35%), Gaps = 28/283 (9%) Query: 4 IANAHNELIHDAVLDYYG-KRLATCSSDKTIKIFEVEGETHKL---IDTLTGHEGPVWRV 59 HN + L + S DKT+ + + + + + GH V V Sbjct: 13 TLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDV 72 Query: 60 DWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA 119 + G S S+D + +W G A H+ V SV ++ A Sbjct: 73 VVSAD--GNYAVSASWDKTLRLWNLATGNSE--ARFVGHTGDVLSVAI--DANSSKIISA 126 Query: 120 SSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGAD 179 S D + V + ++ H V AP +E+ +G FV+ G D Sbjct: 127 SRDKTIRVWNTVGDCA---YVLLGHTDWVTKVRVAPKNLEDGEVDDGRIT---FVSAGMD 180 Query: 180 NLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNE 239 +V+ W N D+ Y +E+ GH++++ V SP S AS +D +W ++ Sbjct: 181 KIVRSWSLNEDS--YRIEADFIGHNNYINVVQPSPD---GSLAASAGKDGQIYVWNLKHK 235 Query: 240 QGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 D ++ ++S S + + + ++ Sbjct: 236 SAFMNF------DAKDEVFALAFSPS-RFWLTAATASGIKIYD 271 Score = 100 bits (249), Expect = 6e-22, Method: Composition-based stats. Identities = 44/246 (17%), Positives = 79/246 (32%), Gaps = 37/246 (15%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H + +D ++ + S DKTI+++ G+ L GH V +V A Sbjct: 106 GHTGDVLSVAIDANSSKIISASRDKTIRVWNTVGD---CAYVLLGHTDWVTKVRVAPKNL 162 Query: 67 GT--------ILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 118 S D V W + A H+ +N VQ +P G L Sbjct: 163 EDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPD--GSLAAS 220 Query: 119 ASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGA 178 A DG++ V K + V + +++P+ ++T Sbjct: 221 AGKDGQIYVWNLKHKSA---FMNFDAKDEVFALAFSPSRF--------------WLTAAT 263 Query: 179 DNLVKIWKYNSDAQTYVLESTLEGHSDW----VRDVAWSPTVLLRSYLASVSQDRTCIIW 234 + +KI+ ++ L+ G++ +AWS L + D +W Sbjct: 264 ASGIKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSAD---GQTLFAGYTDNVIRVW 320 Query: 235 TQDNEQ 240 Sbjct: 321 QVMTAN 326 Score = 73.7 bits (179), Expect = 9e-14, Method: Composition-based stats. Identities = 36/200 (18%), Positives = 66/200 (33%), Gaps = 28/200 (14%) Query: 94 VHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASW 153 H+ V S+ + + LL+ S D + EN + + ++ Sbjct: 13 TLEGHNGWVTSLSTSAAQP-NLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGH------ 65 Query: 154 APATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWS 213 + + + V+ D +++W + T E+ GH+ V VA Sbjct: 66 ----SHIVQDVVVSADGNYAVSASWDKTLRLW----NLATGNSEARFVGHTGDVLSVAID 117 Query: 214 PTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVL---- 269 S + S S+D+T +W N G LL + + A +L + Sbjct: 118 AN---SSKIISASRDKTIRVW---NTVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGR 171 Query: 270 ---ALSGGDNKVTLWKENLE 286 +G D V W N + Sbjct: 172 ITFVSAGMDKIVRSWSLNED 191 Score = 55.2 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 23/87 (26%), Positives = 37/87 (42%), Gaps = 2/87 (2%) Query: 195 VLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFP 254 VL TLEGH+ WV + S + + L S S+D+T I W + + + + Sbjct: 9 VLRGTLEGHNGWVTSL--STSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHS 66 Query: 255 DVLWRASWSLSGNVLALSGGDNKVTLW 281 ++ S GN + D + LW Sbjct: 67 HIVQDVVVSADGNYAVSASWDKTLRLW 93 >5Z56-q nrPDB Length = 504 Score = 127 bits (318), Expect = 7e-30, Method: Composition-based stats. Identities = 61/265 (23%), Positives = 106/265 (40%), Gaps = 35/265 (13%) Query: 22 KRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLI 81 ++ T +DK + +F+ E +++ TL GH V V + HP ++ S S D + I Sbjct: 235 NKILTGGADKNVVVFDKSSE--QILATLKGHTKKVTSVVF-HPSQ-DLVFSASPDATIRI 290 Query: 82 WKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIII 141 W N Q+ H ++V + H G LL +S D + + + + + Sbjct: 291 WSVPNASCVQVVR--AHESAVTGLSL--HATGDYLLSSSDDQYWAFSDIQTGRVLTKVTD 346 Query: 142 DAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLE 201 + + A + P + F TG D+ +KIW D + + Sbjct: 347 ETSGCSLTCAQFHP-------------DGLIFGTGTMDSQIKIW----DLKERTNVANFP 389 Query: 202 GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRAS 261 GHS + +A+S YLA+ + D + +W + KTL + F + Sbjct: 390 GHSGPITSIAFSEN---GYYLATAADDSSVKLWDLRKLKNF--KTLQLDNNFE--VKSLI 442 Query: 262 WSLSGNVLALSGGDNKVTL---WKE 283 + SG LAL G D ++ + W E Sbjct: 443 FDQSGTYLALGGTDVQIYICKQWTE 467 Score = 121 bits (302), Expect = 5e-28, Method: Composition-based stats. Identities = 47/286 (16%), Positives = 93/286 (32%), Gaps = 44/286 (15%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 ++ H + + V + + S D TI+I+ V + + HE V + Sbjct: 256 ILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSV--PNASCVQVVRAHESAVTGLS 313 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 G L S S D + GR S+ Q+ P G + + Sbjct: 314 LH--ATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPD--GLIFGTGT 369 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 D ++ + + KE + H+ + S +++ + T D+ Sbjct: 370 MDSQIKIWDLKERTNVANF--PGHSGPITSIAFS-------------ENGYYLATAADDS 414 Query: 181 LVKIWKYN--SDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII---WT 235 VK+W + +T L++ E V+ + + +YLA D I WT Sbjct: 415 SVKLWDLRKLKNFKTLQLDNNFE-----VKSLIFD---QSGTYLALGGTDVQIYICKQWT 466 Query: 236 QDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 +L + + ++ +A +G D + + Sbjct: 467 ----------EILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFY 502 Score = 96.0 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 37/235 (15%), Positives = 74/235 (31%), Gaps = 35/235 (14%) Query: 52 HEGPVWRVDWA--HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAP 109 H + + P + + D V+++ + + + +A H+ V SV + P Sbjct: 217 HSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQI--LATLKGHTKKVTSVVFHP 274 Query: 110 HEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKE 169 + L+ AS D + + ++ AH V S Sbjct: 275 SQ--DLVFSASPDATIRIWSVPNASCVQ--VVRAHESAVTGLSLH-------------AT 317 Query: 170 SRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSD--WVRDVAWSPTVLLRSYLASVSQ 227 ++ D W + SD QT + + + + + + P L + + Sbjct: 318 GDYLLSSSDDQY---WAF-SDIQTGRVLTKVTDETSGCSLTCAQFHPDGL---IFGTGTM 370 Query: 228 DRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 D IW + + ++S +G LA + D+ V LW Sbjct: 371 DSQIKIWDLKERTN-----VANFPGHSGPITSIAFSENGYYLATAADDSSVKLWD 420 Score = 28.6 bits (62), Expect = 3.5, Method: Composition-based stats. Identities = 6/31 (19%), Positives = 16/31 (51%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEV 38 H+ L ++ K +A+ D+++K + + Sbjct: 474 HSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504 >6GMH-W nrPDB Length = 305 Score = 124 bits (312), Expect = 3e-29, Method: Composition-based stats. Identities = 61/318 (19%), Positives = 112/318 (35%), Gaps = 69/318 (21%) Query: 6 NAHNELIHDAVLDYY----GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 AH++ I + + T S D +K+++ E L +L GH+ V VD Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDI 72 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 +H I AS S D + +W ENG+ QI ++ ++P L + Sbjct: 73 SHTL--PIAASSSLDAHIRLWDLENGK--QIKSIDAGPVDAWTLAFSPD--SQYLATGTH 126 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 GKV++ + +D + S +++P + + +G D + Sbjct: 127 VGKVNIFGVESGK--KEYSLDTRGKFILSIAYSP-------------DGKYLASGAIDGI 171 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII-------- 233 + I+ D T L TLEGH+ +R + +SP L L + S D I Sbjct: 172 INIF----DIATGKLLHTLEGHAMPIRSLTFSPDSQL---LVTASDDGYIKIYDVQHANL 224 Query: 234 ---------WTQDNEQGP--------------------WKKTLLKEEKFPDVLWRASWSL 264 W + P + + D +W ++ Sbjct: 225 AGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNG 284 Query: 265 SGNVLALSGGDNKVTLWK 282 +G+ + G D ++ ++ Sbjct: 285 NGSKIVSVGDDQEIHIYD 302 Score = 66.4 bits (160), Expect = 1e-11, Method: Composition-based stats. Identities = 29/131 (22%), Positives = 49/131 (37%), Gaps = 8/131 (6%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 ++ H I + L T S D IKI++V+ L TL+GH V V Sbjct: 182 LLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHAN--LAGTLSGHASWVLNVA 239 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 + T S S D V +W G + + H V V++ + G ++ Sbjct: 240 FCPDD--THFVSSSSDKSVKVWDV--GTRTCVHTFFDHQDQVWGVKY--NGNGSKIVSVG 293 Query: 121 SDGKVSVVEFK 131 D ++ + + Sbjct: 294 DDQEIHIYDCP 304 >3JB9-L nrPDB Length = 340 Score = 124 bits (310), Expect = 5e-29, Method: Composition-based stats. Identities = 57/299 (19%), Positives = 96/299 (32%), Gaps = 38/299 (12%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H + A D G A+ D+ I ++ V G+ L G +G + + W+ Sbjct: 48 GHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKN-YGVLNGCKGAITDLQWSRD-- 104 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 ++ S D ++ W +G+ +I H H+ VN++ LL S D + Sbjct: 105 SRVVYCSSSDTHLMSWDAVSGQ--KIRKHKGHAGVVNALD-VLKVGSELLTSVSDDCTMK 161 Query: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 V + + I ++ + GG D +KIW Sbjct: 162 VWDSRSKDCIKTI----------------EEKYPLTAVAIAQQGTQVFIGGIDGAIKIW- 204 Query: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT 246 D + L+GH D + +A S S L S S D T I+ ++ Sbjct: 205 ---DLRNNHCSHVLKGHKDIITSLAIS---KDGSSLLSNSMDNTVRIFDVKPFASAQRQL 258 Query: 247 LL---KEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN------LEGKWEPAGEVH 296 + L +WS + + D V +W L G V Sbjct: 259 QIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSATGDLRYVLPGHEGSVNHVD 317 Score = 95.3 bits (235), Expect = 3e-20, Method: Composition-based stats. Identities = 52/235 (22%), Positives = 84/235 (35%), Gaps = 37/235 (15%) Query: 6 NAHNELIHDAVLDYYGKRLATC-SSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 H +++ + G L T S D T+K+++ + I T+ + P+ V A Sbjct: 132 KGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSR--SKDCIKTIEE-KYPLTAVAIA-- 186 Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 + GT + DG + IW N V H + S+ + G LL S D Sbjct: 187 QQGTQVFIGGIDGAIKIWDLRNN--HCSHVLKGHKDIITSLAISKD--GSSLLSNSMDNT 242 Query: 125 VSVVEFK--ENGTTSPIIIDA--HAIGVN--SASWAPATIEEDGEHNGTKESRKFVTGGA 178 V + + K + I + H N +W+ + SR G + Sbjct: 243 VRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWS-------------RNSRFVGAGSS 289 Query: 179 DNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII 233 D V +W D + L GH V V + P + + S S DRT + Sbjct: 290 DKNVYVWSATGDLR-----YVLPGHEGSVNHVDFHPH---QDIILSCSSDRTIFL 336 Score = 72.9 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 32/137 (23%), Positives = 55/137 (40%), Gaps = 13/137 (9%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE--GETHKLIDTLTG--H--EG 54 + H ++I + G L + S D T++IF+V+ + + G H E Sbjct: 211 CSHVLKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEH 270 Query: 55 PVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGP 114 + V W+ + + S D V +W + V H SVN V + PH+ Sbjct: 271 NLLGVAWSRN--SRFVGAGSSDKNVYVW---SATGDLRYVLPGHEGSVNHVDFHPHQ--D 323 Query: 115 LLLVASSDGKVSVVEFK 131 ++L SSD + + E Sbjct: 324 IILSCSSDRTIFLGELN 340 >5FA5-B nrPDB Length = 367 Score = 124 bits (310), Expect = 6e-29, Method: Composition-based stats. Identities = 46/230 (20%), Positives = 89/230 (38%), Gaps = 37/230 (16%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 H++++ + G + + S D IK++++ + ++ + H V V A P Sbjct: 149 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV--VLSSYRAHAAQVTCVA-ASPHKD 205 Query: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 ++ SCS D ++L+W + + + S+ W P + + + +G VS+ Sbjct: 206 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQS-EVFVFGDENGTVSL 264 Query: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 V+ K + H+ V ++P ++ + Sbjct: 265 VDTKSTSCV--LSSAVHSQCVTGLVFSPHSVP-----------------------FLASL 299 Query: 188 NSDAQTYVLESTL------EGHSDWVRDVAWSPTVLLRSYLASVSQDRTC 231 + D VL+S+L + H D+VRD WSP L S L +V D Sbjct: 300 SEDCSLAVLDSSLSELFRSQAHRDFVRDATWSP--LNHSLLTTVGWDHQV 347 Score = 54.4 bits (129), Expect = 6e-08, Method: Composition-based stats. Identities = 39/168 (23%), Positives = 58/168 (34%), Gaps = 25/168 (14%) Query: 116 LLVASSDGKVSVVEFKENGT--TSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKF 173 +LVAS G V + E EN T S H V++ S + Sbjct: 119 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVS-------------VLSSGTQA 165 Query: 174 VTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII 233 V+G D +K+W D V+ S+ H+ V VA SP S S S+D ++ Sbjct: 166 VSGSKDICIKVW----DLAQQVVLSSYRAHAAQVTCVAASPHK--DSVFLSCSEDNRILL 219 Query: 234 WTQDNEQGPWKKTLLKEEKFPDVLWRASWSL-SGNVLALSGGDNKVTL 280 W + + P L +W V + V+L Sbjct: 220 WDTRCPKPASQIGCSAPGYLPTSL---AWHPQQSEVFVFGDENGTVSL 264 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 23/136 (16%), Positives = 39/136 (28%), Gaps = 12/136 (8%) Query: 154 APATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGH-------SDW 206 APA +E E + + G + + W + + EG Sbjct: 48 APACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAG 107 Query: 207 VRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSG 266 V D+ W + + S +W D + K E D++ S SG Sbjct: 108 VADLTW----VGERGILVASDSGAVELWELDENETLIVSKFCKYE-HDDIVSTVSVLSSG 162 Query: 267 NVLALSGGDNKVTLWK 282 D + +W Sbjct: 163 TQAVSGSKDICIKVWD 178 >6Q8F-A nrPDB Length = 514 Score = 123 bits (309), Expect = 8e-29, Method: Composition-based stats. Identities = 54/275 (19%), Positives = 104/275 (37%), Gaps = 27/275 (9%) Query: 9 NELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTL-TGHEGPVWRVDWAHPKFG 67 ++ + + LAT + D IK++++ ++ + + H V + ++ K Sbjct: 265 DDAVLCMCFSRDTEMLATGAQDGKIKVWKI--QSGQCLRRFERAHSKGVTCLSFS--KDS 320 Query: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 + + S S+D + I ++G+ + HS+ VN + + G ++ ASSDG V + Sbjct: 321 SQILSASFDQTIRIHGLKSGKTLK--EFRGHSSFVNEATFT--QDGHYIISASSDGTVKI 376 Query: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 K ++ G + + + ++ EH FV N V I Sbjct: 377 WNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEH--------FVVCNRSNTVVIMNM 428 Query: 188 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTL 247 EG D+V A SP ++ V +D ++ G ++TL Sbjct: 429 QGQIVRSFSSGKREG-GDFV-CCALSPR---GEWIYCVGEDFVLYCFSTV--TGKLERTL 481 Query: 248 LKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 EK + + N++A D + LWK Sbjct: 482 TVHEK---DVIGIAHHPHQNLIATYSEDGLLKLWK 513 Score = 111 bits (276), Expect = 5e-25, Method: Composition-based stats. Identities = 56/299 (18%), Positives = 108/299 (36%), Gaps = 34/299 (11%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEV------EGETHKLIDTLTGHEGPVWRVD 60 + A G+ L T S D I+++ + ++ D + V + Sbjct: 213 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 272 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 ++ +LA+ + DGK+ +WK ++G+ + A HS V + ++ +L AS Sbjct: 273 FSRDT--EMLATGAQDGKIKVWKIQSGQCLRRFERA-HSKGVTCLSFSKDSSQ--ILSAS 327 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 D + + K T H+ VN A++ T++ ++ +D Sbjct: 328 FDQTIRIHGLKSGKTLKEF--RGHSSFVNEATF-------------TQDGHYIISASSDG 372 Query: 181 LVKIWKY--NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDN 238 VKIW + T+ + G V V P + ++ T +I N Sbjct: 373 TVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPE--HFVVCNRSNTVVI---MN 427 Query: 239 EQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 QG ++ ++ + S G + G D + + + GK E VH+ Sbjct: 428 MQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFS-TVTGKLERTLTVHE 485 Score = 86.0 bits (211), Expect = 2e-17, Method: Composition-based stats. Identities = 38/206 (18%), Positives = 70/206 (33%), Gaps = 34/206 (16%) Query: 83 KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIID 142 +E+ + + V +++P G L+ S DG + V F + Sbjct: 199 EEKFPTQLSRHIKFGQKSHVECARFSPD--GQYLVTGSVDGFIEVWNFTTGKIRKDLKYQ 256 Query: 143 AHAI------GVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVL 196 A V ++ +++ TG D +K+WK Q+ Sbjct: 257 AQDNFMMMDDAVLCMCFS-------------RDTEMLATGAQDGKIKVWKI----QSGQC 299 Query: 197 ESTLE-GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPD 255 E HS V +++S S + S S D+T I + G K F + Sbjct: 300 LRRFERAHSKGVTCLSFS---KDSSQILSASFDQTIRIHGL--KSGKTLKEFRGHSSFVN 354 Query: 256 VLWRASWSLSGNVLALSGGDNKVTLW 281 A+++ G+ + + D V +W Sbjct: 355 E---ATFTQDGHYIISASSDGTVKIW 377 Score = 60.6 bits (145), Expect = 7e-10, Method: Composition-based stats. Identities = 31/184 (16%), Positives = 56/184 (30%), Gaps = 22/184 (11%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE----GETHKLIDTLTGHEGPVWRVDWA 62 H+ +++A G + + SSD T+KI+ ++ T K + + G + V V Sbjct: 348 GHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSV-IL 406 Query: 63 HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD 122 PK C+ V+I + + +P G + D Sbjct: 407 LPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSP--RGEWIYCVGED 464 Query: 123 GKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLV 182 + + + H V + P T D L+ Sbjct: 465 FVLYCFSTVTGKLERTLTV--HEKDVIGIAHHPH-------------QNLIATYSEDGLL 509 Query: 183 KIWK 186 K+WK Sbjct: 510 KLWK 513 Score = 33.2 bits (74), Expect = 0.14, Method: Composition-based stats. Identities = 8/47 (17%), Positives = 17/47 (36%) Query: 235 TQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 + E+ P + + + + A +S G L D + +W Sbjct: 196 DVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVW 242 >4LG8-A nrPDB Length = 354 Score = 122 bits (305), Expect = 2e-28, Method: Composition-based stats. Identities = 61/265 (23%), Positives = 106/265 (40%), Gaps = 35/265 (13%) Query: 22 KRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLI 81 ++ T +DK + +F+ E +++ TL GH V V + HP ++ S S D + I Sbjct: 85 NKILTGGADKNVVVFDKSSE--QILATLKGHTKKVTSVVF-HPSQ-DLVFSASPDATIRI 140 Query: 82 WKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIII 141 W N Q+ H ++V + H G LL +S D + + + + + Sbjct: 141 WSVPNASCVQVVR--AHESAVTGLSL--HATGDYLLSSSDDQYWAFSDIQTGRVLTKVTD 196 Query: 142 DAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLE 201 + + A + P + F TG D+ +KIW D + + Sbjct: 197 ETSGCSLTCAQFHP-------------DGLIFGTGTMDSQIKIW----DLKERTNVANFP 239 Query: 202 GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRAS 261 GHS + +A+S YLA+ + D + +W + KTL + F + Sbjct: 240 GHSGPITSIAFSEN---GYYLATAADDSSVKLWDLRKLKNF--KTLQLDNNFE--VKSLI 292 Query: 262 WSLSGNVLALSGGDNKVTL---WKE 283 + SG LAL G D ++ + W E Sbjct: 293 FDQSGTYLALGGTDVQIYICKQWTE 317 Score = 116 bits (290), Expect = 1e-26, Method: Composition-based stats. Identities = 47/286 (16%), Positives = 93/286 (32%), Gaps = 44/286 (15%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 ++ H + + V + + S D TI+I+ V + + HE V + Sbjct: 106 ILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSV--PNASCVQVVRAHESAVTGLS 163 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 G L S S D + GR S+ Q+ P G + + Sbjct: 164 LH--ATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPD--GLIFGTGT 219 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 D ++ + + KE + H+ + S +++ + T D+ Sbjct: 220 MDSQIKIWDLKERTNVANF--PGHSGPITSIAFS-------------ENGYYLATAADDS 264 Query: 181 LVKIWKYN--SDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII---WT 235 VK+W + +T L++ E V+ + + +YLA D I WT Sbjct: 265 SVKLWDLRKLKNFKTLQLDNNFE-----VKSLIFD---QSGTYLALGGTDVQIYICKQWT 316 Query: 236 QDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 +L + + ++ +A +G D + + Sbjct: 317 ----------EILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFY 352 Score = 92.2 bits (227), Expect = 2e-19, Method: Composition-based stats. Identities = 37/235 (15%), Positives = 74/235 (31%), Gaps = 35/235 (14%) Query: 52 HEGPVWRVDWA--HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAP 109 H + + P + + D V+++ + + + +A H+ V SV + P Sbjct: 67 HSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQI--LATLKGHTKKVTSVVFHP 124 Query: 110 HEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKE 169 + L+ AS D + + ++ AH V S Sbjct: 125 SQ--DLVFSASPDATIRIWSVPNASCVQ--VVRAHESAVTGLSLH-------------AT 167 Query: 170 SRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSD--WVRDVAWSPTVLLRSYLASVSQ 227 ++ D W + SD QT + + + + + + P L + + Sbjct: 168 GDYLLSSSDDQY---WAF-SDIQTGRVLTKVTDETSGCSLTCAQFHPDGL---IFGTGTM 220 Query: 228 DRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 D IW + + ++S +G LA + D+ V LW Sbjct: 221 DSQIKIWDLKERTN-----VANFPGHSGPITSIAFSENGYYLATAADDSSVKLWD 270 Score = 27.9 bits (60), Expect = 5.4, Method: Composition-based stats. Identities = 6/31 (19%), Positives = 16/31 (51%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEV 38 H+ L ++ K +A+ D+++K + + Sbjct: 324 HSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 354 >6J6H-n nrPDB Length = 455 Score = 120 bits (301), Expect = 6e-28, Method: Composition-based stats. Identities = 50/280 (17%), Positives = 98/280 (35%), Gaps = 28/280 (10%) Query: 7 AHNELIHDAVLDY-YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 H E G + + +D TIKI++ + ++ + GH P+ + + Sbjct: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD-YECLRDFQGHNKPIKALRFTEDC 218 Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 S S+D V IW E G+ A V S PHE +V S+ K+ Sbjct: 219 QS--FLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE----FIVGLSNSKI 272 Query: 126 SVVEFKENGTTSPII-IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 + + + + D H + + + P + KF++ D V+I Sbjct: 273 LHYDDRVSENQGLVQTYDHHLSSILALKYFP-------------DGSKFISSSEDKTVRI 319 Query: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 244 W+ + + T + HS + + P+ ++Y + S D ++ + Sbjct: 320 WENQINVPIKQISDTAQ-HS--MPFLNVHPS---QNYFCAQSMDNRIYSFSLKPKYKRHP 373 Query: 245 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 K + K ++S G + +++ W N Sbjct: 374 KKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWN 413 Score = 66.4 bits (160), Expect = 1e-11, Method: Composition-based stats. Identities = 40/277 (14%), Positives = 88/277 (31%), Gaps = 28/277 (10%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 HN+ I + + S D+++KI++ ET K+ L H + P Sbjct: 203 QGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDT--ETGKVKTRL--HLNSTPADVESRPT 258 Query: 66 FGTILASCSYDGKVLIWKEE-NGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 + K+L + + + + + H +S+ ++++ P G + +S D Sbjct: 259 NPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD--GSKFISSSEDKT 316 Query: 125 VSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 V + E + N I A N F DN + Sbjct: 317 VRIWENQINVPIKQISDTAQ--------------HSMPFLNVHPSQNYFCAQSMDNRIYS 362 Query: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 244 + + + + +GHS ++ + + Y+ S W + + Sbjct: 363 FSLKPKYKRHP-KKIFKGHSSAGYGISLAFSGD-GRYICSGDSKSRLFTWDWNTSRLLNN 420 Query: 245 KTLLKEEKFPDVLWRASWSLS-GNVLALSGGDNKVTL 280 + + + + W + + SG K+ + Sbjct: 421 IKIPGNK----PITQVDWHPQETSKVICSGAAGKIYV 453 Score = 57.9 bits (138), Expect = 5e-09, Method: Composition-based stats. Identities = 28/164 (17%), Positives = 57/164 (34%), Gaps = 9/164 (5%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFE--VEGETHKLIDTLTGHEGPVWR 58 +V + H I G + + S DKT++I+E + ++ DT H P Sbjct: 285 LVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQ-HSMPFLN 343 Query: 59 VDWAHPKFGTILASCSYDGKVLIWKEE-NGRWSQIAVHAVHSASVNSVQWAPHEYGPLLL 117 V HP + S D ++ + + + + HS++ + A G + Sbjct: 344 V---HPSQN-YFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYIC 399 Query: 118 VASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEED 161 S ++ ++ + + I I + W P + Sbjct: 400 SGDSKSRLFTWDWNTSRLLNNIKIPG-NKPITQVDWHPQETSKV 442 >5UZ7-B nrPDB Length = 351 Score = 119 bits (298), Expect = 1e-27, Method: Composition-based stats. Identities = 41/231 (17%), Positives = 74/231 (32%), Gaps = 29/231 (12%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 H + ++ T S D T ++++E T H G V + A Sbjct: 150 LAGHTGYLSCCRFL-DDNQIVTSSGDTTCALWDIETGQQTTTFTG--HTGDVMSLSLAPD 206 Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 + S + D +W G Q H + +N++ + P+ G S D Sbjct: 207 T--RLFVSGACDASAKLWDVREGMCRQ--TFTGHESDINAICFFPN--GNAFATGSDDAT 260 Query: 125 VSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 + + + + D G+ S S++ + R + G D + Sbjct: 261 CRLFDLRADQELMTYSHDNIICGITSVSFSKS-------------GRLLLAGYDDFNCNV 307 Query: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 W DA L GH + V + + + +A+ S D IW Sbjct: 308 W----DALKADRAGVLAGHDNRVSCLGVTDDGMA---VATGSWDSFLKIWN 351 Score = 111 bits (276), Expect = 5e-25, Method: Composition-based stats. Identities = 51/282 (18%), Positives = 92/282 (32%), Gaps = 34/282 (12%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 H I+ + L + S D + I++ L V +A Sbjct: 61 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR--SSWVMTCAYAP 118 Query: 64 PKFGTILASCSYDGKVLIW--KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 G +A D I+ K G A H+ ++ ++ ++ +S Sbjct: 119 --SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD---NQIVTSSG 173 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 D ++ + + T+ H V S S AP ++R FV+G D Sbjct: 174 DTTCALWDIETGQQTT--TFTGHTGDVMSLSLAP-------------DTRLFVSGACDAS 218 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQG 241 K+W D + + T GH + + + P + A+ S D TC ++ +Q Sbjct: 219 AKLW----DVREGMCRQTFTGHESDINAICFFPN---GNAFATGSDDATCRLFDLRADQE 271 Query: 242 PWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKE 283 + + S+S SG +L D +W Sbjct: 272 LMTY---SHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDA 310 Score = 107 bits (266), Expect = 8e-24, Method: Composition-based stats. Identities = 38/272 (13%), Positives = 76/272 (27%), Gaps = 34/272 (12%) Query: 12 IHDAVLDYYGKRLATCSSDKTIKIFEV--EGETHKLIDTLTGHEGPVWRVDWAHPKFGTI 69 + G +A D I+ + ++ L GH G + + Sbjct: 111 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ--- 167 Query: 70 LASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVE 129 + + S D +W E Q H+ V S+ AP L + + D + + Sbjct: 168 IVTSSGDTTCALWDIET--GQQTTTFTGHTGDVMSLSLAPDT--RLFVSGACDASAKLWD 223 Query: 130 FKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNS 189 +E H +N+ + P F TG D +++ + Sbjct: 224 VREGMCRQTF--TGHESDINAICFFP-------------NGNAFATGSDDATCRLFDLRA 268 Query: 190 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLK 249 D + H + + + L + D C +W Sbjct: 269 DQELMTY-----SHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL---- 319 Query: 250 EEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 + + + G +A D+ + +W Sbjct: 320 -AGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 350 Score = 69.8 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 23/130 (17%), Positives = 47/130 (36%), Gaps = 8/130 (6%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRV- 59 H I+ G AT S D T ++F++ + + + T + H+ + + Sbjct: 229 CRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRAD--QELMTYS-HDNIICGIT 285 Query: 60 DWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA 119 + K G +L + D +W + + V A H V+ + + G + Sbjct: 286 SVSFSKSGRLLLAGYDDFNCNVWDAL--KADRAGVLAGHDNRVSCLGVT--DDGMAVATG 341 Query: 120 SSDGKVSVVE 129 S D + + Sbjct: 342 SWDSFLKIWN 351 Score = 29.8 bits (65), Expect = 1.6, Method: Composition-based stats. Identities = 6/39 (15%), Positives = 13/39 (33%) Query: 244 KKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 +T ++ W +L + D K+ +W Sbjct: 56 MRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD 94 >5OQL-d nrPDB Length = 446 Score = 119 bits (298), Expect = 1e-27, Method: Composition-based stats. Identities = 49/313 (15%), Positives = 98/313 (31%), Gaps = 49/313 (15%) Query: 4 IANAHNELIHDAVLDYYG-KRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 + N H + ++ D +A+ S D +K++++ + + H V + + Sbjct: 61 LGNGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEE-TWRVAAHNNIVKGLTFT 119 Query: 63 HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHA-VHSASVNSVQWAPHEYGPLLLVASS 121 + K L SC+ DG + +W + + S+ + H +S Sbjct: 120 NDKK---LLSCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSF--HRSANTFAASSG 173 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKF-------- 173 G + + + + + I + + + G + F Sbjct: 174 QGCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPV 233 Query: 174 ----------------------VTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVA 211 D+ + I+ + + ++ GH V DV Sbjct: 234 IKTVLHFACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQK---GHVAAVMDVE 290 Query: 212 WSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLAL 271 +SPT L S S DRT +W +D K ++R W++ + Sbjct: 291 FSPT---GEELVSGSYDRTIRLWRRDAGHSRDVY----HTKRMQRVFRTMWTMDSKYILT 343 Query: 272 SGGDNKVTLWKEN 284 D V LW+ N Sbjct: 344 GSDDGNVRLWRAN 356 Score = 81.4 bits (199), Expect = 4e-16, Method: Composition-based stats. Identities = 36/232 (15%), Positives = 80/232 (34%), Gaps = 25/232 (10%) Query: 14 DAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASC 73 A S I+I+++E T + V + + +++ S Sbjct: 158 SLSFHRSANTFAASSGQGCIRIWDLEHSTAGQAIQWPSFVDTITDVCF-NQVETSVIGSV 216 Query: 74 SYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKEN 133 + D ++++ + +H A N + + P E L VAS D + + + + N Sbjct: 217 ATDRSIILFDLRTN--MPVIKTVLHFA-CNRIVFNPMEAMN-LAVASEDHNIYIFDAR-N 271 Query: 134 GTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQT 193 + I H V ++P + V+G D +++W+ ++ Sbjct: 272 FDKALNIQKGHVAAVMDVEFSPT-------------GEELVSGSYDRTIRLWRRDAGHSR 318 Query: 194 YVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKK 245 V H+ ++ V + + Y+ + S D +W + + K Sbjct: 319 DVY------HTKRMQRVFRTMWTMDSKYILTGSDDGNVRLWRANASERSGVK 364 Score = 69.8 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 35/190 (18%), Positives = 75/190 (39%), Gaps = 22/190 (11%) Query: 10 ELIHDAVLDY-YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGT 68 + I D + + + ++D++I +F++ + L R+ + +P Sbjct: 198 DTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLH---FACNRIVF-NPMEAM 253 Query: 69 ILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 LA S D + I+ N + + H A+V V+++P G L+ S D + + Sbjct: 254 NLAVASEDHNIYIFDARNFD-KALNIQKGHVAAVMDVEFSPT--GEELVSGSYDRTIRLW 310 Query: 129 EFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN 188 ++ G + + V W T +S+ +TG D V++W+ N Sbjct: 311 R-RDAGHSRDVYHTKRMQRVFRTMW-------------TMDSKYILTGSDDGNVRLWRAN 356 Query: 189 SDAQTYVLES 198 + ++ V + Sbjct: 357 ASERSGVKAT 366 Score = 29.4 bits (64), Expect = 2.0, Method: Composition-based stats. Identities = 6/23 (26%), Positives = 9/23 (39%) Query: 267 NVLALSGGDNKVTLWKENLEGKW 289 N +A GD V +W + Sbjct: 80 NCIASGSGDGVVKVWDLTTRDEE 102 >5G04-R nrPDB Length = 499 Score = 116 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 60/235 (25%), Positives = 90/235 (38%), Gaps = 29/235 (12%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 +H+ + + Y L++ S I +V H + TL+GH V + WA Sbjct: 264 MTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEH-HVATLSGHSQEVCGLRWAPD 320 Query: 65 KFGTILASCSYDGKVLIWKEE--NGRWSQIAVHAVHSASVNSVQWAPHEYGPLL-LVASS 121 G LAS D V +W G W + H +V +V W P + L +S Sbjct: 321 --GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTS 378 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 D + + S +DAH+ V S W+P E H G A N Sbjct: 379 DRHIRIWNVCSGACLSA--VDAHSQ-VCSILWSPHYKELISGH-----------GFAQNQ 424 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ 236 + IWKY T + L+GH+ V + SP + +AS + D T +W Sbjct: 425 LVIWKYP----TMAKVAELKGHTSRVLSLTMSPD---GATVASAAADETLRLWRC 472 Score = 104 bits (259), Expect = 4e-23, Method: Composition-based stats. Identities = 59/277 (21%), Positives = 96/277 (34%), Gaps = 36/277 (12%) Query: 10 ELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTI 69 E I G LA +S +++++V + K + +T H V + W I Sbjct: 227 EYISSVAWIKEGNYLAVGTSSAEVQLWDV--QQQKRLRNMTSHSARVGSLSWN----SYI 280 Query: 70 LASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVE 129 L+S S G + +A + HS V ++WAP G L +D V+V Sbjct: 281 LSSGSRSGHIHHHDVRVAEHH-VATLSGHSQEVCGLRWAPD--GRHLASGGNDNLVNVWP 337 Query: 130 -FKENGTTSPII-IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 G P+ H V + +W P GT +D ++IW Sbjct: 338 SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGT----------SDRHIRIWNV 387 Query: 188 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVS--QDRTCIIWTQDNEQGPWKK 245 S S ++ HS V + WSP L S +IW P Sbjct: 388 CS----GACLSAVDAHSQ-VCSILWSPHYKE---LISGHGFAQNQLVIWKY-----PTMA 434 Query: 246 TLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 + + + + + S G +A + D + LW+ Sbjct: 435 KVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 Score = 98.3 bits (243), Expect = 3e-21, Method: Composition-based stats. Identities = 54/270 (20%), Positives = 93/270 (34%), Gaps = 34/270 (12%) Query: 17 LDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYD 76 +D+ + + D ++ ++ + + + V W K G LA + Sbjct: 190 VDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWI--KEGNYLAVGTSS 247 Query: 77 GKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTT 136 +V +W + + ++ HSA V S+ W + +L S G + + + Sbjct: 248 AEVQLWDVQQQK--RLRNMTSHSARVGSLSWNSY----ILSSGSRSGHIHHHDVR-VAEH 300 Query: 137 SPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVL 196 + H+ V WAP + R +GG DNLV +W +V Sbjct: 301 HVATLSGHSQEVCGLRWAP-------------DGRHLASGGNDNLVNVWPSAPGEGGWVP 347 Query: 197 ESTLEGHSDWVRDVAWSPTVLLRSYLASVS--QDRTCIIWTQDNEQGPWKKTLLKEEKFP 254 T H V+ VAW P + LA+ DR IW G + + Sbjct: 348 LQTFTQHQGAVKAVAWCP--WQSNVLATGGGTSDRHIRIWN--VCSGACLSAVDAHSQ-- 401 Query: 255 DVLWRASWSLSGNVLALSGG--DNKVTLWK 282 + WS L G N++ +WK Sbjct: 402 --VCSILWSPHYKELISGHGFAQNQLVIWK 429 Score = 85.6 bits (210), Expect = 2e-17, Method: Composition-based stats. Identities = 34/189 (17%), Positives = 71/189 (37%), Gaps = 23/189 (12%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEG--ETHKLIDTLTGHEGPVWRV 59 V + H++ + G+ LA+ +D + ++ + T T H+G V V Sbjct: 302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 361 Query: 60 DWAHPKFGTILASCS--YDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLL 117 W P +LA+ D + IW +G ++ HS V S+ W+PH + Sbjct: 362 AWC-PWQSNVLATGGGTSDRHIRIWNVCSGAC--LSAVDAHSQ-VCSILWSPHYKELISG 417 Query: 118 VASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGG 177 + ++ + ++ + + H V S + +P + + Sbjct: 418 HGFAQNQLVIWKYPTMAKVAE--LKGHTSRVLSLTMSP-------------DGATVASAA 462 Query: 178 ADNLVKIWK 186 AD +++W+ Sbjct: 463 ADETLRLWR 471 >5Y88-O nrPDB Length = 451 Score = 115 bits (288), Expect = 2e-26, Method: Composition-based stats. Identities = 56/280 (20%), Positives = 91/280 (32%), Gaps = 37/280 (13%) Query: 4 IANAHNELIHDAVLDY-YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 + N H + +D + T S+D T+K++++ T KL TL GH V V + Sbjct: 134 VINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLA--TGKLKTTLAGHVMTVRDVAVS 191 Query: 63 HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD 122 L S S D V W E + I + H + V +V P L+ A D Sbjct: 192 DRH--PYLFSVSEDKTVKCWDLEKNQI--IRDYYGHLSGVRTVSIHPT--LDLIATAGRD 245 Query: 123 GKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLV 182 + + + + I + H +N P + V+ D V Sbjct: 246 SVIKLWDMR--TRIPVITLVGHKGPINQVQCTPV-------------DPQVVSSSTDATV 290 Query: 183 KIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGP 242 ++W D L H VR A P +AS D W Sbjct: 291 RLW----DVVAGKTMKVLTHHKRSVRATALHPKEFS---VASACTDD-IRSWGLAEGSLL 342 Query: 243 WKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 K ++ S + +VL G + ++ + Sbjct: 343 TNFESEK----TGIINTLSINQD-DVLFAGGDNGVLSFYD 377 Score = 108 bits (269), Expect = 4e-24, Method: Composition-based stats. Identities = 52/239 (21%), Positives = 83/239 (34%), Gaps = 33/239 (13%) Query: 43 HKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASV 102 KL + GH G V V P + S D + +W G+ A H +V Sbjct: 129 WKLSRVINGHLGWVRCVA-IDPVDNEWFITGSNDTTMKVWDLATGKLK--TTLAGHVMTV 185 Query: 103 NSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDG 162 V + + P L S D V + ++N H GV + S P Sbjct: 186 RDVAVS--DRHPYLFSVSEDKTVKCWDLEKNQIIRDYY--GHLSGVRTVSIHPTL----- 236 Query: 163 EHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYL 222 T G D+++K+W D +T + TL GH + V +P + + Sbjct: 237 --------DLIATAGRDSVIKLW----DMRTRIPVITLVGHKGPINQVQCTP---VDPQV 281 Query: 223 ASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 S S D T +W D G K L ++ + + +A + D+ + W Sbjct: 282 VSSSTDATVRLW--DVVAGKTMKVLTHHKR---SVRATALHPKEFSVASACTDD-IRSW 334 Score = 99.1 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 44/287 (15%), Positives = 97/287 (33%), Gaps = 34/287 (11%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 + H + D + L + S DKT+K +++E ++I GH V V Sbjct: 174 LKTTLAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKN--QIIRDYYGHLSGVRTVS 231 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 HP ++A+ D + +W + H +N VQ P + P ++ +S Sbjct: 232 -IHPTL-DLIATAGRDSVIKLWDMRTR--IPVITLVGHKGPINQVQCTPVD--PQVVSSS 285 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 +D V + + T ++ H V + + P V + Sbjct: 286 TDATVRLWDVVAGKTMK--VLTHHKRSVRATALHPKEFS--------------VASACTD 329 Query: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNE- 239 ++ W + ES G + ++ + L + + + + Sbjct: 330 DIRSWGLAEGSLLTNFESEKTG---IINTLS----INQDDVLFAGGDNGVLSFYDYKSGH 382 Query: 240 --QGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 Q + ++ + + +++ +G L D + +WK++ Sbjct: 383 KYQSLATREMVGSLEGERSVLCSTFDKTGLRLITGEADKSIKIWKQD 429 Score = 64.4 bits (155), Expect = 6e-11, Method: Composition-based stats. Identities = 40/220 (18%), Positives = 81/220 (36%), Gaps = 27/220 (12%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 V+ H I+ ++ + S+D T+++++V K + LT H+ V Sbjct: 259 VITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVA--GKTMKVLTHHKRSVRATAL 316 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 HPK ++ ++C+ D + W G + +N++ +L Sbjct: 317 -HPKEFSVASACTDD--IRSWGLAEGSLLTNFESEK-TGIINTLSINQD---DVLFAGGD 369 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 +G +S ++K + A V S + + + G + +TG AD Sbjct: 370 NGVLSFYDYKSGHKYQSL---ATREMVGSLEGERSVLCSTFDKTGL----RLITGEADKS 422 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSY 221 +KIWK + A +AW+P + + + Sbjct: 423 IKIWKQDETATKESE-----------PGLAWNPNLSAKRF 451 Score = 55.2 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 22/89 (24%), Positives = 30/89 (33%), Gaps = 7/89 (7%) Query: 194 YVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKF 253 + L + GH WVR VA P + + + S D T +W G K TL Sbjct: 129 WKLSRVINGHLGWVRCVAIDP--VDNEWFITGSNDTTMKVWDL--ATGKLKTTLAGHVM- 183 Query: 254 PDVLWRASWSLSGNVLALSGGDNKVTLWK 282 + + S L D V W Sbjct: 184 --TVRDVAVSDRHPYLFSVSEDKTVKCWD 210 >4GGA-A nrPDB Length = 420 Score = 112 bits (281), Expect = 1e-25, Method: Composition-based stats. Identities = 60/235 (25%), Positives = 90/235 (38%), Gaps = 29/235 (12%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 +H+ + + Y L++ S I +V H + TL+GH V + WA Sbjct: 185 MTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEH-HVATLSGHSQEVCGLRWAPD 241 Query: 65 KFGTILASCSYDGKVLIWKEE--NGRWSQIAVHAVHSASVNSVQWAPHEYGPLL-LVASS 121 G LAS D V +W G W + H +V +V W P + L +S Sbjct: 242 --GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTS 299 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 D + + S +DAH+ V S W+P E H G A N Sbjct: 300 DRHIRIWNVCSGACLSA--VDAHSQ-VCSILWSPHYKELISGH-----------GFAQNQ 345 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ 236 + IWKY T + L+GH+ V + SP + +AS + D T +W Sbjct: 346 LVIWKYP----TMAKVAELKGHTSRVLSLTMSPD---GATVASAAADETLRLWRC 393 Score = 101 bits (251), Expect = 4e-22, Method: Composition-based stats. Identities = 59/277 (21%), Positives = 96/277 (34%), Gaps = 36/277 (12%) Query: 10 ELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTI 69 E I G LA +S +++++V + K + +T H V + W I Sbjct: 148 EYISSVAWIKEGNYLAVGTSSAEVQLWDV--QQQKRLRNMTSHSARVGSLSWN----SYI 201 Query: 70 LASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVE 129 L+S S G + +A + HS V ++WAP G L +D V+V Sbjct: 202 LSSGSRSGHIHHHDVRVAEHH-VATLSGHSQEVCGLRWAPD--GRHLASGGNDNLVNVWP 258 Query: 130 -FKENGTTSPII-IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 G P+ H V + +W P GT +D ++IW Sbjct: 259 SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGT----------SDRHIRIWNV 308 Query: 188 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVS--QDRTCIIWTQDNEQGPWKK 245 S S ++ HS V + WSP L S +IW P Sbjct: 309 CS----GACLSAVDAHSQ-VCSILWSPHYKE---LISGHGFAQNQLVIWKY-----PTMA 355 Query: 246 TLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 + + + + + S G +A + D + LW+ Sbjct: 356 KVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 392 Score = 95.7 bits (236), Expect = 2e-20, Method: Composition-based stats. Identities = 54/270 (20%), Positives = 93/270 (34%), Gaps = 34/270 (12%) Query: 17 LDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYD 76 +D+ + + D ++ ++ + + + V W K G LA + Sbjct: 111 VDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWI--KEGNYLAVGTSS 168 Query: 77 GKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTT 136 +V +W + + ++ HSA V S+ W + +L S G + + + Sbjct: 169 AEVQLWDVQQQK--RLRNMTSHSARVGSLSWNSY----ILSSGSRSGHIHHHDVR-VAEH 221 Query: 137 SPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVL 196 + H+ V WAP + R +GG DNLV +W +V Sbjct: 222 HVATLSGHSQEVCGLRWAP-------------DGRHLASGGNDNLVNVWPSAPGEGGWVP 268 Query: 197 ESTLEGHSDWVRDVAWSPTVLLRSYLASVS--QDRTCIIWTQDNEQGPWKKTLLKEEKFP 254 T H V+ VAW P + LA+ DR IW G + + Sbjct: 269 LQTFTQHQGAVKAVAWCP--WQSNVLATGGGTSDRHIRIWN--VCSGACLSAVDAHSQ-- 322 Query: 255 DVLWRASWSLSGNVLALSGG--DNKVTLWK 282 + WS L G N++ +WK Sbjct: 323 --VCSILWSPHYKELISGHGFAQNQLVIWK 350 Score = 83.7 bits (205), Expect = 9e-17, Method: Composition-based stats. Identities = 34/189 (17%), Positives = 71/189 (37%), Gaps = 23/189 (12%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEG--ETHKLIDTLTGHEGPVWRV 59 V + H++ + G+ LA+ +D + ++ + T T H+G V V Sbjct: 223 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 282 Query: 60 DWAHPKFGTILASCS--YDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLL 117 W P +LA+ D + IW +G ++ HS V S+ W+PH + Sbjct: 283 AWC-PWQSNVLATGGGTSDRHIRIWNVCSGAC--LSAVDAHSQ-VCSILWSPHYKELISG 338 Query: 118 VASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGG 177 + ++ + ++ + + H V S + +P + + Sbjct: 339 HGFAQNQLVIWKYPTMAKVAE--LKGHTSRVLSLTMSP-------------DGATVASAA 383 Query: 178 ADNLVKIWK 186 AD +++W+ Sbjct: 384 ADETLRLWR 392 >5LCW-Q nrPDB Length = 374 Score = 111 bits (278), Expect = 3e-25, Method: Composition-based stats. Identities = 60/235 (25%), Positives = 90/235 (38%), Gaps = 29/235 (12%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 +H+ + + Y L++ S I +V H + TL+GH V + WA Sbjct: 139 MTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEH-HVATLSGHSQEVCGLRWAPD 195 Query: 65 KFGTILASCSYDGKVLIWKEE--NGRWSQIAVHAVHSASVNSVQWAPHEYGPLL-LVASS 121 G LAS D V +W G W + H +V +V W P + L +S Sbjct: 196 --GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTS 253 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 D + + S +DAH+ V S W+P E H G A N Sbjct: 254 DRHIRIWNVCSGACLSA--VDAHSQ-VCSILWSPHYKELISGH-----------GFAQNQ 299 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ 236 + IWKY T + L+GH+ V + SP + +AS + D T +W Sbjct: 300 LVIWKYP----TMAKVAELKGHTSRVLSLTMSPD---GATVASAAADETLRLWRC 347 Score = 100 bits (248), Expect = 9e-22, Method: Composition-based stats. Identities = 59/277 (21%), Positives = 96/277 (34%), Gaps = 36/277 (12%) Query: 10 ELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTI 69 E I G LA +S +++++V + K + +T H V + W I Sbjct: 102 EYISSVAWIKEGNYLAVGTSSAEVQLWDV--QQQKRLRNMTSHSARVGSLSWN----SYI 155 Query: 70 LASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVE 129 L+S S G + +A + HS V ++WAP G L +D V+V Sbjct: 156 LSSGSRSGHIHHHDVRVAEHH-VATLSGHSQEVCGLRWAPD--GRHLASGGNDNLVNVWP 212 Query: 130 -FKENGTTSPII-IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 G P+ H V + +W P GT +D ++IW Sbjct: 213 SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGT----------SDRHIRIWNV 262 Query: 188 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVS--QDRTCIIWTQDNEQGPWKK 245 S S ++ HS V + WSP L S +IW P Sbjct: 263 CS----GACLSAVDAHSQ-VCSILWSPHYKE---LISGHGFAQNQLVIWKY-----PTMA 309 Query: 246 TLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 + + + + + S G +A + D + LW+ Sbjct: 310 KVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 346 Score = 94.5 bits (233), Expect = 5e-20, Method: Composition-based stats. Identities = 54/270 (20%), Positives = 93/270 (34%), Gaps = 34/270 (12%) Query: 17 LDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYD 76 +D+ + + D ++ ++ + + + V W K G LA + Sbjct: 65 VDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWI--KEGNYLAVGTSS 122 Query: 77 GKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTT 136 +V +W + + ++ HSA V S+ W + +L S G + + + Sbjct: 123 AEVQLWDVQQQK--RLRNMTSHSARVGSLSWNSY----ILSSGSRSGHIHHHDVR-VAEH 175 Query: 137 SPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVL 196 + H+ V WAP + R +GG DNLV +W +V Sbjct: 176 HVATLSGHSQEVCGLRWAP-------------DGRHLASGGNDNLVNVWPSAPGEGGWVP 222 Query: 197 ESTLEGHSDWVRDVAWSPTVLLRSYLASVS--QDRTCIIWTQDNEQGPWKKTLLKEEKFP 254 T H V+ VAW P + LA+ DR IW G + + Sbjct: 223 LQTFTQHQGAVKAVAWCP--WQSNVLATGGGTSDRHIRIWN--VCSGACLSAVDAHSQ-- 276 Query: 255 DVLWRASWSLSGNVLALSGG--DNKVTLWK 282 + WS L G N++ +WK Sbjct: 277 --VCSILWSPHYKELISGHGFAQNQLVIWK 304 Score = 82.6 bits (202), Expect = 2e-16, Method: Composition-based stats. Identities = 34/189 (17%), Positives = 71/189 (37%), Gaps = 23/189 (12%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEG--ETHKLIDTLTGHEGPVWRV 59 V + H++ + G+ LA+ +D + ++ + T T H+G V V Sbjct: 177 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 236 Query: 60 DWAHPKFGTILASCS--YDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLL 117 W P +LA+ D + IW +G ++ HS V S+ W+PH + Sbjct: 237 AWC-PWQSNVLATGGGTSDRHIRIWNVCSGAC--LSAVDAHSQ-VCSILWSPHYKELISG 292 Query: 118 VASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGG 177 + ++ + ++ + + H V S + +P + + Sbjct: 293 HGFAQNQLVIWKYPTMAKVAE--LKGHTSRVLSLTMSP-------------DGATVASAA 337 Query: 178 ADNLVKIWK 186 AD +++W+ Sbjct: 338 ADETLRLWR 346 >4V7E-Bg nrPDB Length = 380 Score = 111 bits (277), Expect = 4e-25, Method: Composition-based stats. Identities = 45/292 (15%), Positives = 88/292 (30%), Gaps = 33/292 (11%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 H+ ++ + + S D + ++ T + + H V Sbjct: 58 CCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWN--ALTSQKTHAIKLHCPWVMECA 115 Query: 61 WAHPKFGTILASCSYDGKVLIWK-----EENGRWSQIAVHAVHSASVNSVQWAPHEYGPL 115 +A G +A D I+ + +G V H +S Q+ P + L Sbjct: 116 FAPN--GQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRL 173 Query: 116 LLVASSDGKVSVVEFKENGTTSPIIID---AHAIGVNSASWAPATIEEDGEHNGTKESRK 172 + S D + + S + H V S S + + Sbjct: 174 I-TGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSIN------------SLNANM 220 Query: 173 FVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 232 F++G D V++W T T GH + V + P + S D TC Sbjct: 221 FISGSCDTTVRLWDLRI---TSRAVRTYHGHEGDINSVKFFPD---GQRFGTGSDDGTCR 274 Query: 233 IWTQDNEQGPWKK--TLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 ++ + + ++ ++S+SG +L + +W Sbjct: 275 LFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWD 326 Score = 101 bits (252), Expect = 3e-22, Method: Composition-based stats. Identities = 46/285 (16%), Positives = 94/285 (32%), Gaps = 31/285 (10%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHK-----LIDTLTGHEGPVWRVDWA 62 H + + G+ +A D IF + + + + LTGH+G + Sbjct: 107 HCPWVMECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYV 166 Query: 63 HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHA---VHSASVNSVQWAPHEYGPLLLVA 119 + ++ + S D ++W G+ I H+A V S+ + + Sbjct: 167 PDQETRLI-TGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSIN-SLNANMFISG 224 Query: 120 SSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGAD 179 S D V + + + + H +NS + P + ++F TG D Sbjct: 225 SCDTTVRLWDLRITSR-AVRTYHGHEGDINSVKFFP-------------DGQRFGTGSDD 270 Query: 180 NLVKIWKYNSDAQTYVLESTLEGHSDW---VRDVAWSPTVLLRSYLASVSQDRTCIIWTQ 236 +++ + Q V + + + V VA+S + L + + C +W Sbjct: 271 GTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFS---ISGRLLFAGYSNGDCYVWDT 327 Query: 237 DNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 + L+ + S G+ L D + +W Sbjct: 328 LLAEMVLNLGTLQNS-HEGRISCLGLSSDGSALCTGSWDKNLKIW 371 Score = 89.5 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 37/233 (15%), Positives = 68/233 (29%), Gaps = 50/233 (21%) Query: 4 IANAHNELIHDAVLDY-YGKRLATCSSDKTIKIFEVEGETHKLIDTL-----TGHEGPVW 57 + H RL T S D+T +++V T + I +GH V Sbjct: 152 VLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVT--TGQRISIFGSEFPSGHTADVL 209 Query: 58 RVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLL 117 + + + S S D V +W + + H +NSV++ P G Sbjct: 210 SLS-INSLNANMFISGSCDTTVRLWDLRI-TSRAVRTYHGHEGDINSVKFFPD--GQRFG 265 Query: 118 VASSDGKVSVVEFKENGTTS-----PIIIDAHAIGVNSASWAPATIEEDGEHNG------ 166 S DG + + + P D V S +++ + ++ Sbjct: 266 TGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVW 325 Query: 167 ---------------------------TKESRKFVTGGADNLVKIWKYNSDAQ 192 + + TG D +KIW ++ + Sbjct: 326 DTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIWAFSGHRK 378 Score = 70.6 bits (171), Expect = 7e-13, Method: Composition-based stats. Identities = 41/199 (20%), Positives = 66/199 (33%), Gaps = 23/199 (11%) Query: 91 QIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNS 150 HS V S+ W P + ++ AS DG++ V + I H V Sbjct: 58 CCRTLQGHSGKVYSLDWTPEKN--WIVSASQDGRLIVW--NALTSQKTHAIKLHCPWVME 113 Query: 151 ASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQ---TYVLESTLEGHSDWV 207 ++AP + GG D+ I+ +S A + L GH + Sbjct: 114 CAFAP-------------NGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYA 160 Query: 208 RDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASW-SLSG 266 + P + L + S D+TC++W Q + S SL+ Sbjct: 161 SSCQYVPD--QETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNA 218 Query: 267 NVLALSGGDNKVTLWKENL 285 N+ D V LW + Sbjct: 219 NMFISGSCDTTVRLWDLRI 237 Score = 57.5 bits (137), Expect = 6e-09, Method: Composition-based stats. Identities = 19/98 (19%), Positives = 42/98 (42%), Gaps = 8/98 (8%) Query: 193 TYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEK 252 V TL+GHS V + W+P ++++ S SQD I+W + + Sbjct: 55 DLVCCRTLQGHSGKVYSLDWTPE---KNWIVSASQDGRLIVWNA-----LTSQKTHAIKL 106 Query: 253 FPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWE 290 + +++ +G +A G D+ +++ + + + Sbjct: 107 HCPWVMECAFAPNGQSVACGGLDSACSIFNLSSQADRD 144 Score = 54.8 bits (130), Expect = 5e-08, Method: Composition-based stats. Identities = 26/160 (16%), Positives = 44/160 (27%), Gaps = 23/160 (14%) Query: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 V F + H+ V S W P E V+ D + +W Sbjct: 49 VSFNPTDLVCCRTLQGHSGKVYSLDWTP-------------EKNWIVSASQDGRLIVWNA 95 Query: 188 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ--DNEQGPWKK 245 + +T+ ++ H WV + A++P +A D C I+ ++ Sbjct: 96 LTSQKTHAIKL----HCPWVMECAFAPN---GQSVACGGLDSACSIFNLSSQADRDGNMP 148 Query: 246 TLLKEEKFPDVLWRASWSLSG-NVLALSGGDNKVTLWKEN 284 + L GD LW Sbjct: 149 VSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVT 188 Score = 35.2 bits (79), Expect = 0.036, Method: Composition-based stats. Identities = 15/54 (27%), Positives = 20/54 (37%), Gaps = 11/54 (20%) Query: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPV 56 + N+H I L G L T S DK +KI+ +GH V Sbjct: 338 TLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIW-----------AFSGHRKIV 380 >5K1B-B nrPDB Length = 677 Score = 111 bits (276), Expect = 5e-25, Method: Composition-based stats. Identities = 48/269 (17%), Positives = 96/269 (35%), Gaps = 25/269 (9%) Query: 12 IHDAVLDYYGKRLATCSSDKTIKIFEVEGETHK-LIDTLTGHEGPVWRVDWAHPKFGTIL 70 ++ LD RL T D I+I+ V I ++ H V + G L Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCN--GKTL 90 Query: 71 ASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEF 130 S S D V +W G ++ H V ++ +A + L+ A D ++ + + Sbjct: 91 ISASSDTTVKVWNAHKG--FCMSTLRTHKDYVKALAYAKDK--ELVASAGLDRQIFLWDV 146 Query: 131 KENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSD 190 + A V ++S + + + V+G + ++++W D Sbjct: 147 NTLTA-----LTASNNTVTTSSLS-GNKDSIYSLAMNQLGTIIVSGSTEKVLRVW----D 196 Query: 191 AQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKE 250 +T L+GH+D V+ + + S S D T +W+ ++ + Sbjct: 197 PRTCAKLMKLKGHTDNVKALLL---NRDGTQCLSGSSDGTIRLWSLGQQR-----CIATY 248 Query: 251 EKFPDVLWRASWSLSGNVLALSGGDNKVT 279 + +W + + + G D K+ Sbjct: 249 RVHDEGVWALQVNDAFTHVYSGGRDRKIY 277 Score = 103 bits (257), Expect = 9e-23, Method: Composition-based stats. Identities = 51/304 (16%), Positives = 110/304 (36%), Gaps = 54/304 (17%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 + H + ++D VL GK L + SSD T+K++ + TL H+ V + + Sbjct: 68 IASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWN--AHKGFCMSTLRTHKDYVKALAY 125 Query: 62 AHPKFGTILASCSYDGKVLIWK-------EENGRWSQIAVHAVHSASVNSVQWAPHEYGP 114 A K ++AS D ++ +W + + + + S+ S+ ++ G Sbjct: 126 AKDK--ELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAM--NQLGT 181 Query: 115 LLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFV 174 +++ S++ + V + + + + H V + ++ + + Sbjct: 182 IIVSGSTEKVLRVWDPRTCAKL--MKLKGHTDNVKALLLN-------------RDGTQCL 226 Query: 175 TGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT---- 230 +G +D +++W +T H + V + +++ S +DR Sbjct: 227 SGSSDGTIRLWSLGQQ----RCIATYRVHDEGVWALQV---NDAFTHVYSGGRDRKIYCT 279 Query: 231 ------CIIWTQDNEQGPWKKTLLKEEKFPDVLWRAS-------WSLSG--NVLALSGGD 275 + + + K L + P +W A+ W+L G N A D Sbjct: 280 DLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYD 339 Query: 276 NKVT 279 N T Sbjct: 340 NDCT 343 Score = 93.3 bits (230), Expect = 1e-19, Method: Composition-based stats. Identities = 43/218 (19%), Positives = 74/218 (33%), Gaps = 31/218 (14%) Query: 70 LASCSYDGKVLIWKEENGRWSQ-IAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 L + D + IW + IA H+ VN + + G L+ ASSD V V Sbjct: 45 LFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCN--GKTLISASSDTTVKVW 102 Query: 129 EFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN 188 + S + H V + ++A K+ + G D + +W N Sbjct: 103 NAHKGFCMS--TLRTHKDYVKALAYA-------------KDKELVASAGLDRQIFLWDVN 147 Query: 189 SDA-----QTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPW 243 + V S+L G+ D + +A L + + S S ++ +W Sbjct: 148 TLTALTASNNTVTTSSLSGNKDSIYSLAM---NQLGTIIVSGSTEKVLRVWDPR-----T 199 Query: 244 KKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 L+K + D + + G D + LW Sbjct: 200 CAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLW 237 Score = 90.6 bits (223), Expect = 6e-19, Method: Composition-based stats. Identities = 29/117 (24%), Positives = 52/117 (44%), Gaps = 9/117 (7%) Query: 168 KESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQ 227 + T G D++++IW N Q + +++E H+DWV D+ L S S Sbjct: 40 PALNRLFTAGRDSIIRIWSVNQHKQDPYI-ASMEHHTDWVNDIVLCCN---GKTLISASS 95 Query: 228 DRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 D T +W +G TL + D + +++ ++A +G D ++ LW N Sbjct: 96 DTTVKVWN--AHKGFCMSTLRTHK---DYVKALAYAKDKELVASAGLDRQIFLWDVN 147 Score = 86.4 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 43/320 (13%), Positives = 95/320 (29%), Gaps = 50/320 (15%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE-------GETHKLIDTLTGHE 53 + H + + + +A+ D+ I +++V +L+G++ Sbjct: 109 CMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNK 168 Query: 54 GPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYG 113 ++ + A + GTI+ S S + + +W +++ H+ +V ++ + G Sbjct: 169 DSIYSL--AMNQLGTIIVSGSTEKVLRVWDPRT--CAKLMKLKGHTDNVKAL--LLNRDG 222 Query: 114 PLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKF 173 L SSDG + + + + + H GV + Sbjct: 223 TQCLSGSSDGTIRLWSLGQQRCIATYRV--HDEGVWAL-------------QVNDAFTHV 267 Query: 174 VTGGADNLVKIWKY-NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 232 +GG D + N D + + E V + + + + T Sbjct: 268 YSGGRDRKIYCTDLRNPDIRVLICEEK-----APVLKMELDRSADPPPAIWVATTKSTVN 322 Query: 233 IWTQDN-------------EQGPWKKTLLKEEKFPD---VLWRASWSLSGNVLALSGGDN 276 WT P + ++ + + + +N Sbjct: 323 KWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHILNDKRHILTKDTNN 382 Query: 277 KVTLWKENLEGKWEPAGEVH 296 V W K E G+V Sbjct: 383 NVAYWDVLKACKVEDLGKVD 402 Score = 77.2 bits (188), Expect = 7e-15, Method: Composition-based stats. Identities = 31/190 (16%), Positives = 64/190 (33%), Gaps = 27/190 (14%) Query: 98 HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTT-SPIIIDAHAIGVNSASWAPA 156 + VN++Q P L A D + + ++ ++ H VN Sbjct: 29 NRNGVNALQLDP--ALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCC- 85 Query: 157 TIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV 216 + ++ +D VK+W +A STL H D+V+ +A++ Sbjct: 86 ------------NGKTLISASSDTTVKVW----NAHKGFCMSTLRTHKDYVKALAYA--- 126 Query: 217 LLRSYLASVSQDRTCIIWTQDNEQGPWKK----TLLKEEKFPDVLWRASWSLSGNVLALS 272 + +AS DR +W + T D ++ + + G ++ Sbjct: 127 KDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSG 186 Query: 273 GGDNKVTLWK 282 + + +W Sbjct: 187 STEKVLRVWD 196 >2AQ5-A nrPDB Length = 402 Score = 110 bits (274), Expect = 8e-25, Method: Composition-based stats. Identities = 42/175 (24%), Positives = 65/175 (37%), Gaps = 22/175 (12%) Query: 111 EYGPLLLVASSDGKVSVVEFKENGTTSPI--IIDAHAIGVNSASWAPATIEEDGEHNGTK 168 ++ L+ AS G V+ + G ++ H V +W P Sbjct: 45 KFMALICEASGGGAFLVLPLGKTGRVDKNVPLVCGHTAPVLDIAWCPHN----------- 93 Query: 169 ESRKFVTGGADNLVKIWKYNSDAQTYVLES---TLEGHSDWVRDVAWSPTVLLRSYLASV 225 +G D V +W+ L TLEGH+ V VAW PT ++ L S Sbjct: 94 -DNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTA--QNVLLSA 150 Query: 226 SQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTL 280 D ++W D G TL + PD ++ WS G ++ S D +V + Sbjct: 151 GCDNVILVW--DVGTGAAVLTL-GPDVHPDTIYSVDWSRDGALICTSCRDKRVRV 202 Score = 99.1 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 35/143 (24%), Positives = 58/143 (40%), Gaps = 9/143 (6%) Query: 2 VVIANAHNELIHDAVLDYYGK-RLATCSSDKTIKIFEVEGETHKL-----IDTLTGHEGP 55 V + H + D + +A+ S D T+ ++E+ L + TL GH Sbjct: 74 VPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKR 133 Query: 56 VWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPL 115 V V W HP +L S D +L+W G VH ++ SV W+ G L Sbjct: 134 VGIVAW-HPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWS--RDGAL 190 Query: 116 LLVASSDGKVSVVEFKENGTTSP 138 + + D +V V+E ++ + Sbjct: 191 ICTSCRDKRVRVIEPRKGTVVAE 213 Score = 61.8 bits (148), Expect = 3e-10, Method: Composition-based stats. Identities = 23/84 (27%), Positives = 40/84 (47%), Gaps = 5/84 (5%) Query: 202 GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW--TQDNEQGPWKKTLLKEEKFPDVLWR 259 GH+ V D+AW P + +AS S+D T ++W P ++ ++ E + Sbjct: 79 GHTAPVLDIAWCPHN--DNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGI 136 Query: 260 ASWSLSG-NVLALSGGDNKVTLWK 282 +W + NVL +G DN + +W Sbjct: 137 VAWHPTAQNVLLSAGCDNVILVWD 160 Score = 35.9 bits (81), Expect = 0.023, Method: Composition-based stats. Identities = 12/83 (14%), Positives = 24/83 (28%), Gaps = 7/83 (8%) Query: 206 WVRDVAWSP-----TVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRA 260 V W + + S ++ + G K + + Sbjct: 29 RVSQTTWDSGFCAVNPKFMALICEASGGGAFLVLPL-GKTGRVDKNVPLVCGHTAPVLDI 87 Query: 261 SWSL-SGNVLALSGGDNKVTLWK 282 +W + NV+A D V +W+ Sbjct: 88 AWCPHNDNVIASGSEDCTVMVWE 110 >5WLC-LO nrPDB Length = 923 Score = 109 bits (273), Expect = 1e-24, Method: Composition-based stats. Identities = 49/293 (16%), Positives = 96/293 (32%), Gaps = 45/293 (15%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 H + + G R+ T S D IK++++ + + T H V V +A K Sbjct: 342 QGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDIT--SGFCLATFEEHTSSVTAVQFA--K 397 Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG-K 124 G ++ S S DG V W R+ + + A G ++ S D Sbjct: 398 RGQVMFSSSLDGTVRAWDLI--RYRNFRTFTG-TERIQFNCLAVDPSGEVVCAGSLDNFD 454 Query: 125 VSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 + V + + H V+ S++ +E+ + D ++I Sbjct: 455 IHVWSVQTGQLLD--ALSGHEGPVSCLSFS-------------QENSVLASASWDKTIRI 499 Query: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQG--- 241 W +Q +E +SD V ++ P +A + I+ ++ + Sbjct: 500 WSIFGRSQ---QVEPIEVYSD-VLALSMRPD---GKEVAVSTLKGQISIFNIEDAKQVGN 552 Query: 242 -PWKKTLLKEEKFPD-----------VLWRASWSLSGNVLALSGGDNKVTLWK 282 +K ++ D +S G + G +N + L+ Sbjct: 553 IDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYD 605 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 57/303 (18%), Positives = 102/303 (33%), Gaps = 56/303 (18%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLID-TLTGHEGPVWRVDWAHP 64 H + I + + T S D + KI+ V+ E L T GH V ++H Sbjct: 143 AGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHD 202 Query: 65 KFGTILASCSYDGKVLIW-----------------------KEENGRW--SQIAVHAVHS 99 + + + S DG V +W W ++ + Sbjct: 203 QEK--IYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQ 260 Query: 100 ASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIE 159 A V V + P LL V + G+ + + + + + VN+ S Sbjct: 261 AKVKCVTFHP--ATRLLAVGFTSGEFRLYDLPDFTLIQQLSM--GQNPVNTVS------- 309 Query: 160 EDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLR 219 + G + L ++ Y +++Y+L+ +GH D +A+SP Sbjct: 310 ------VNQTGEWLAFGSS-KLGQLLVYEWQSESYILKQ--QGHFDSTNSLAYSPD---G 357 Query: 220 SYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVT 279 S + + S+D +W D G T E+ + ++ G V+ S D V Sbjct: 358 SRVVTASEDGKIKVW--DITSGFCLATF---EEHTSSVTAVQFAKRGQVMFSSSLDGTVR 412 Query: 280 LWK 282 W Sbjct: 413 AWD 415 Score = 86.0 bits (211), Expect = 2e-17, Method: Composition-based stats. Identities = 39/245 (15%), Positives = 82/245 (33%), Gaps = 59/245 (24%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFE----------------------- 37 + H + G+ + + S D T++ ++ Sbjct: 379 CLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAV 438 Query: 38 -------------------VEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGK 78 +T +L+D L+GHEGPV + ++ + ++LAS S+D Sbjct: 439 DPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS--QENSVLASASWDKT 496 Query: 79 VLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSP 138 + IW GR Q+ V+S V ++ P G + V++ G++S+ ++ Sbjct: 497 IRIWSI-FGRSQQVEPIEVYSD-VLALSMRPD--GKEVAVSTLKGQISIFNIEDAKQVGN 552 Query: 139 IIIDAHAIGVNSASWAPATIEEDGEHNG--------TKESRKFVTGGADNLVKIWKYNSD 190 I + S + + + V GG +N + ++ ++ Sbjct: 553 I---DCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNE 609 Query: 191 AQTYV 195 Sbjct: 610 VLLKR 614 Score = 83.3 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 40/290 (13%), Positives = 89/290 (30%), Gaps = 36/290 (12%) Query: 13 HDAVLDYYGKRLATCSSDKTIKIF---EVEGETH----KLIDTLTGHEGPVWRVDWAHPK 65 G+ A S + ++I+ +V + GH + + W+ + Sbjct: 100 SAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWS--Q 156 Query: 66 FGTILASCSYDGKVLIWKEENGRWS-QIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 + + S D IW ++ + H V ++ + + S DG Sbjct: 157 DSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQ--EKIYTVSKDGA 214 Query: 125 VSVVEFKE------------NGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRK 172 V V EF + + + I ++ + + A + +R Sbjct: 215 VFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRL 274 Query: 173 FVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 232 G +++ + L L + V V+ +LA S Sbjct: 275 LAVGFTSGEFRLYDLPD----FTLIQQLSMGQNPVNTVSV---NQTGEWLAFGSS----K 323 Query: 233 IWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 + + + +LK++ D ++S G+ + + D K+ +W Sbjct: 324 LGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWD 373 Score = 79.1 bits (193), Expect = 2e-15, Method: Composition-based stats. Identities = 47/295 (15%), Positives = 100/295 (33%), Gaps = 53/295 (17%) Query: 15 AVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCS 74 GK+L + + +F++ + H + +D K GT+L S Sbjct: 20 ITFSDDGKQLLS-PVGNRVSVFDLINNKSFTFE--YEHRKNIAAIDLN--KQGTLLISID 74 Query: 75 YDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENG 134 DG+ ++ N + + H ++V+++P L + ++ Sbjct: 75 EDGRAIL---VNFKARNVLHHFNFKEKCSAVKFSPDGRLFALASGRFLQIWKTPDVNKDR 131 Query: 135 TTSPIIID----AHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSD 190 +P + H + S +W+ ++SR +T D KIW +S+ Sbjct: 132 QFAPFVRHRVHAGHFQDITSLTWS-------------QDSRFILTTSKDLSAKIWSVDSE 178 Query: 191 AQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW---------------- 234 + +T GH D+V +S + +VS+D +W Sbjct: 179 EKNLA-ATTFNGHRDYVMGAFFSHDQEK---IYTVSKDGAVFVWEFTKRPSDDDDNESED 234 Query: 235 -----TQDNEQGPWKKTLLKEEKFPDV--LWRASWSLSGNVLALSGGDNKVTLWK 282 D + W+ T K + + + ++ + +LA+ + L+ Sbjct: 235 DDKQEEVDISKYSWRIT-KKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYD 288 Score = 48.7 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 41/248 (16%), Positives = 77/248 (31%), Gaps = 35/248 (14%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWR--VDWA 62 + H + LA+ S DKTI+I+ + G + ++ V+ + + Sbjct: 469 LSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPI------EVYSDVLALS 522 Query: 63 HPKFGTILASCSYDGKVLIWKEEN----GRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 118 G +A + G++ I+ E+ G + + E Sbjct: 523 MRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTT 582 Query: 119 --ASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTG 176 S DG V G + I + V + + S+K Sbjct: 583 IHYSFDGMAIV----AGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLEFLNSKKMTEA 638 Query: 177 GADNLVKIWKYNSDAQTYVLESTLEGH-------------SDWVRDVAWSPTVLLRSYLA 223 G+ +L+ NSD + ++++L G V V +SPT A Sbjct: 639 GSLDLIDDAGENSDLED-RIDNSLPGSQRGGDLSTRKMRPEVRVTSVQFSPTANA---FA 694 Query: 224 SVSQDRTC 231 + S + Sbjct: 695 AASTEGLL 702 Score = 38.3 bits (87), Expect = 0.004, Method: Composition-based stats. Identities = 17/85 (20%), Positives = 26/85 (30%), Gaps = 8/85 (9%) Query: 208 RDVAWSPTVLLRSYLASVSQDRTCIIWTQ----DNEQGPWKKTLLKEEKFPDVLWRASWS 263 V +SP L + LAS R IW + Q + +WS Sbjct: 100 SAVKFSPDGRLFA-LASG---RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWS 155 Query: 264 LSGNVLALSGGDNKVTLWKENLEGK 288 + + D +W + E K Sbjct: 156 QDSRFILTTSKDLSAKIWSVDSEEK 180 >5WLC-LU nrPDB Length = 489 Score = 108 bits (269), Expect = 4e-24, Method: Composition-based stats. Identities = 56/339 (16%), Positives = 103/339 (30%), Gaps = 90/339 (26%) Query: 7 AHNELIHDAVLDYYG-KRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP- 64 H + ++ +Y +LAT S+D IK + + T + + H G V + P Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMS--TREEFVSFKAHYGLVTGLCVTQPR 122 Query: 65 --------KFGTILASCSYDGKVLIW---------------KEENGRWSQIAVHAVHSA- 100 K + SCS D V +W I SA Sbjct: 123 FHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAF 182 Query: 101 ----------------------------SVNSVQWAPHE---------YGPLLLVASSDG 123 V+ + W +L SD Sbjct: 183 QGIDSHRENSTFATGGAKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDN 242 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 + + + + N T I+ + N+ W P E+ FVT D+ Sbjct: 243 SIVLYDLRTNSPTQKIV---QTMRTNAICWNPM------------EAFNFVTANEDHNAY 287 Query: 184 IWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPW 243 + + +++ + + H V DV +SPT + + S D++ I+ ++ Sbjct: 288 YYDMRNLSRSLNV---FKDHVSAVMDVDFSPT---GDEIVTGSYDKSIRIYKTNHGHSRE 341 Query: 244 KKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 K +++ +S+ + D V LW+ Sbjct: 342 IY----HTKRMQHVFQVKYSMDSKYIISGSDDGNVRLWR 376 Score = 61.8 bits (148), Expect = 3e-10, Method: Composition-based stats. Identities = 22/103 (21%), Positives = 36/103 (34%), Gaps = 23/103 (22%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGP-------- 55 + H + D G + T S DK+I+I+ T GH Sbjct: 300 VFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIY----------KTNHGHSREIYHTKRMQ 349 Query: 56 -VWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAV 97 V++V ++ + S S DG V +W + W + V Sbjct: 350 HVFQVKYSMD--SKYIISGSDDGNVRLW--RSKAWERSNVKTT 388 Score = 42.5 bits (98), Expect = 2e-04, Method: Composition-based stats. Identities = 18/92 (19%), Positives = 29/92 (31%), Gaps = 8/92 (8%) Query: 202 GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRAS 261 GH D V +A + L + LA+ S D W + + + Sbjct: 65 GHRDGVYAIAKNYGSLNK--LATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPR 122 Query: 262 WS------LSGNVLALSGGDNKVTLWKENLEG 287 + S N + D V LW N++ Sbjct: 123 FHDKKPDLKSQNFMLSCSDDKTVKLWSINVDD 154 >5I2T-A nrPDB Length = 742 Score = 107 bits (268), Expect = 4e-24, Method: Composition-based stats. Identities = 49/293 (16%), Positives = 96/293 (32%), Gaps = 45/293 (15%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 H + + G R+ T S D IK++++ + + T H V V +A K Sbjct: 367 QGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDIT--SGFCLATFEEHTSSVTAVQFA--K 422 Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG-K 124 G ++ S S DG V W R+ + + A G ++ S D Sbjct: 423 RGQVMFSSSLDGTVRAWDLI--RYRNFRTFTG-TERIQFNCLAVDPSGEVVCAGSLDNFD 479 Query: 125 VSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 + V + + H V+ S++ +E+ + D ++I Sbjct: 480 IHVWSVQTGQLLDA--LSGHEGPVSCLSFS-------------QENSVLASASWDKTIRI 524 Query: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQG--- 241 W +Q +E +SD V ++ P +A + I+ ++ + Sbjct: 525 WSIFGRSQ---QVEPIEVYSD-VLALSMRPD---GKEVAVSTLKGQISIFNIEDAKQVGN 577 Query: 242 -PWKKTLLKEEKFPD-----------VLWRASWSLSGNVLALSGGDNKVTLWK 282 +K ++ D +S G + G +N + L+ Sbjct: 578 IDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYD 630 Score = 100 bits (249), Expect = 6e-22, Method: Composition-based stats. Identities = 57/303 (18%), Positives = 102/303 (33%), Gaps = 56/303 (18%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLID-TLTGHEGPVWRVDWAHP 64 H + I + + T S D + KI+ V+ E L T GH V ++H Sbjct: 168 AGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHD 227 Query: 65 KFGTILASCSYDGKVLIW-----------------------KEENGRW--SQIAVHAVHS 99 + + + S DG V +W W ++ + Sbjct: 228 QEK--IYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQ 285 Query: 100 ASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIE 159 A V V + P LL V + G+ + + + + + VN+ S Sbjct: 286 AKVKCVTFHP--ATRLLAVGFTSGEFRLYDLPDFTLIQQLSM--GQNPVNTVS------- 334 Query: 160 EDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLR 219 + G + L ++ Y +++Y+L+ +GH D +A+SP Sbjct: 335 ------VNQTGEWLAFGSS-KLGQLLVYEWQSESYILKQ--QGHFDSTNSLAYSPD---G 382 Query: 220 SYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVT 279 S + + S+D +W D G T E+ + ++ G V+ S D V Sbjct: 383 SRVVTASEDGKIKVW--DITSGFCLATF---EEHTSSVTAVQFAKRGQVMFSSSLDGTVR 437 Query: 280 LWK 282 W Sbjct: 438 AWD 440 Score = 84.5 bits (207), Expect = 5e-17, Method: Composition-based stats. Identities = 39/245 (15%), Positives = 82/245 (33%), Gaps = 59/245 (24%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFE----------------------- 37 + H + G+ + + S D T++ ++ Sbjct: 404 CLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAV 463 Query: 38 -------------------VEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGK 78 +T +L+D L+GHEGPV + ++ + ++LAS S+D Sbjct: 464 DPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS--QENSVLASASWDKT 521 Query: 79 VLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSP 138 + IW GR Q+ V+S V ++ P G + V++ G++S+ ++ Sbjct: 522 IRIWSI-FGRSQQVEPIEVYSD-VLALSMRPD--GKEVAVSTLKGQISIFNIEDAKQVGN 577 Query: 139 IIIDAHAIGVNSASWAPATIEEDGEHNG--------TKESRKFVTGGADNLVKIWKYNSD 190 I + S + + + V GG +N + ++ ++ Sbjct: 578 I---DCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNE 634 Query: 191 AQTYV 195 Sbjct: 635 VLLKR 639 Score = 82.2 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 40/290 (13%), Positives = 89/290 (30%), Gaps = 36/290 (12%) Query: 13 HDAVLDYYGKRLATCSSDKTIKIF---EVEGETH----KLIDTLTGHEGPVWRVDWAHPK 65 G+ A S + ++I+ +V + GH + + W+ + Sbjct: 125 SAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWS--Q 181 Query: 66 FGTILASCSYDGKVLIWKEENGRWS-QIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 + + S D IW ++ + H V ++ + + S DG Sbjct: 182 DSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQ--EKIYTVSKDGA 239 Query: 125 VSVVEFKE------------NGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRK 172 V V EF + + + I ++ + + A + +R Sbjct: 240 VFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRL 299 Query: 173 FVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 232 G +++ + L L + V V+ +LA S Sbjct: 300 LAVGFTSGEFRLYDLPD----FTLIQQLSMGQNPVNTVSV---NQTGEWLAFGSS----K 348 Query: 233 IWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 + + + +LK++ D ++S G+ + + D K+ +W Sbjct: 349 LGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWD 398 Score = 77.5 bits (189), Expect = 6e-15, Method: Composition-based stats. Identities = 47/295 (15%), Positives = 100/295 (33%), Gaps = 53/295 (17%) Query: 15 AVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCS 74 GK+L + + +F++ + H + +D K GT+L S Sbjct: 45 ITFSDDGKQLLS-PVGNRVSVFDLINNKSFTFE--YEHRKNIAAIDLN--KQGTLLISID 99 Query: 75 YDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENG 134 DG+ ++ N + + H ++V+++P L + ++ Sbjct: 100 EDGRAIL---VNFKARNVLHHFNFKEKCSAVKFSPDGRLFALASGRFLQIWKTPDVNKDR 156 Query: 135 TTSPIIID----AHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSD 190 +P + H + S +W+ ++SR +T D KIW +S+ Sbjct: 157 QFAPFVRHRVHAGHFQDITSLTWS-------------QDSRFILTTSKDLSAKIWSVDSE 203 Query: 191 AQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW---------------- 234 + +T GH D+V +S + +VS+D +W Sbjct: 204 EKNLA-ATTFNGHRDYVMGAFFSHDQEK---IYTVSKDGAVFVWEFTKRPSDDDDNESED 259 Query: 235 -----TQDNEQGPWKKTLLKEEKFPDV--LWRASWSLSGNVLALSGGDNKVTLWK 282 D + W+ T K + + + ++ + +LA+ + L+ Sbjct: 260 DDKQEEVDISKYSWRIT-KKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYD 313 Score = 47.9 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 41/248 (16%), Positives = 77/248 (31%), Gaps = 35/248 (14%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWR--VDWA 62 + H + LA+ S DKTI+I+ + G + ++ V+ + + Sbjct: 494 LSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPI------EVYSDVLALS 547 Query: 63 HPKFGTILASCSYDGKVLIWKEEN----GRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 118 G +A + G++ I+ E+ G + + E Sbjct: 548 MRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTT 607 Query: 119 --ASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTG 176 S DG V G + I + V + + S+K Sbjct: 608 IHYSFDGMAIV----AGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLEFLNSKKMTEA 663 Query: 177 GADNLVKIWKYNSDAQTYVLESTLEGH-------------SDWVRDVAWSPTVLLRSYLA 223 G+ +L+ NSD + ++++L G V V +SPT A Sbjct: 664 GSLDLIDDAGENSDLED-RIDNSLPGSQRGGDLSTRKMRPEVRVTSVQFSPTANA---FA 719 Query: 224 SVSQDRTC 231 + S + Sbjct: 720 AASTEGLL 727 Score = 37.9 bits (86), Expect = 0.006, Method: Composition-based stats. Identities = 17/85 (20%), Positives = 26/85 (30%), Gaps = 8/85 (9%) Query: 208 RDVAWSPTVLLRSYLASVSQDRTCIIWTQ----DNEQGPWKKTLLKEEKFPDVLWRASWS 263 V +SP L + LAS R IW + Q + +WS Sbjct: 125 SAVKFSPDGRLFA-LASG---RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWS 180 Query: 264 LSGNVLALSGGDNKVTLWKENLEGK 288 + + D +W + E K Sbjct: 181 QDSRFILTTSKDLSAKIWSVDSEEK 205 >4N14-A nrPDB Length = 314 Score = 107 bits (266), Expect = 7e-24, Method: Composition-based stats. Identities = 60/235 (25%), Positives = 90/235 (38%), Gaps = 29/235 (12%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 +H+ + + Y L++ S I +V H + TL+GH V + WA Sbjct: 101 MTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEH-HVATLSGHSQEVCGLRWAPD 157 Query: 65 KFGTILASCSYDGKVLIWKEE--NGRWSQIAVHAVHSASVNSVQWAPHEYGPLL-LVASS 121 G LAS D V +W G W + H +V +V W P + L +S Sbjct: 158 --GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTS 215 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 D + + S +DAH+ V S W+P E H G A N Sbjct: 216 DRHIRIWNVCSGACLSA--VDAHSQ-VCSILWSPHYKELISGH-----------GFAQNQ 261 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ 236 + IWKY T + L+GH+ V + SP + +AS + D T +W Sbjct: 262 LVIWKYP----TMAKVAELKGHTSRVLSLTMSPD---GATVASAAADETLRLWRC 309 Score = 95.7 bits (236), Expect = 2e-20, Method: Composition-based stats. Identities = 59/277 (21%), Positives = 96/277 (34%), Gaps = 36/277 (12%) Query: 10 ELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTI 69 E I G LA +S +++++V + K + +T H V + W I Sbjct: 64 EYISSVAWIKEGNYLAVGTSSAEVQLWDV--QQQKRLRNMTSHSARVGSLSWN----SYI 117 Query: 70 LASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVE 129 L+S S G + +A + HS V ++WAP G L +D V+V Sbjct: 118 LSSGSRSGHIHHHDVRVAEHH-VATLSGHSQEVCGLRWAPD--GRHLASGGNDNLVNVWP 174 Query: 130 -FKENGTTSPII-IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 G P+ H V + +W P GT +D ++IW Sbjct: 175 SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGT----------SDRHIRIWNV 224 Query: 188 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVS--QDRTCIIWTQDNEQGPWKK 245 S S ++ HS V + WSP L S +IW P Sbjct: 225 CS----GACLSAVDAHSQ-VCSILWSPHYKE---LISGHGFAQNQLVIWKY-----PTMA 271 Query: 246 TLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 + + + + + S G +A + D + LW+ Sbjct: 272 KVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 308 Score = 90.6 bits (223), Expect = 8e-19, Method: Composition-based stats. Identities = 54/270 (20%), Positives = 93/270 (34%), Gaps = 34/270 (12%) Query: 17 LDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYD 76 +D+ + + D ++ ++ + + + V W K G LA + Sbjct: 27 VDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWI--KEGNYLAVGTSS 84 Query: 77 GKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTT 136 +V +W + + ++ HSA V S+ W + +L S G + + + Sbjct: 85 AEVQLWDVQQQK--RLRNMTSHSARVGSLSWNSY----ILSSGSRSGHIHHHDVR-VAEH 137 Query: 137 SPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVL 196 + H+ V WAP + R +GG DNLV +W +V Sbjct: 138 HVATLSGHSQEVCGLRWAP-------------DGRHLASGGNDNLVNVWPSAPGEGGWVP 184 Query: 197 ESTLEGHSDWVRDVAWSPTVLLRSYLASVS--QDRTCIIWTQDNEQGPWKKTLLKEEKFP 254 T H V+ VAW P + LA+ DR IW G + + Sbjct: 185 LQTFTQHQGAVKAVAWCP--WQSNVLATGGGTSDRHIRIWN--VCSGACLSAVDAHSQ-- 238 Query: 255 DVLWRASWSLSGNVLALSGG--DNKVTLWK 282 + WS L G N++ +WK Sbjct: 239 --VCSILWSPHYKELISGHGFAQNQLVIWK 266 Score = 79.5 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 34/189 (17%), Positives = 71/189 (37%), Gaps = 23/189 (12%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEG--ETHKLIDTLTGHEGPVWRV 59 V + H++ + G+ LA+ +D + ++ + T T H+G V V Sbjct: 139 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAV 198 Query: 60 DWAHPKFGTILASCS--YDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLL 117 W P +LA+ D + IW +G ++ HS V S+ W+PH + Sbjct: 199 AWC-PWQSNVLATGGGTSDRHIRIWNVCSGAC--LSAVDAHSQ-VCSILWSPHYKELISG 254 Query: 118 VASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGG 177 + ++ + ++ + + H V S + +P + + Sbjct: 255 HGFAQNQLVIWKYPTMAKVAE--LKGHTSRVLSLTMSP-------------DGATVASAA 299 Query: 178 ADNLVKIWK 186 AD +++W+ Sbjct: 300 ADETLRLWR 308 >5XYI-g nrPDB Length = 335 Score = 104 bits (259), Expect = 5e-23, Method: Composition-based stats. Identities = 58/285 (20%), Positives = 103/285 (36%), Gaps = 40/285 (14%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 HN + D L L T S D T++++++ T K GH+ V V ++ Sbjct: 78 GHNHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTK--KLFLGHKKDVLGVTFSP--C 133 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAP---HEYGPLLLVASSDG 123 + S D +V IW +++ S+ V SV AP ++ V DG Sbjct: 134 NRRIISVGRDNQVKIWNILGENKAELQC----SSWVTSVACAPMADETSPLVIAVGCWDG 189 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 KV + ++ AH S + P + + +TGG+D V Sbjct: 190 KVYIWSIEKEAKL-IKEFKAHDGRCTSVDFTP-------------DGKWVITGGSDRKVV 235 Query: 184 IWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT------QD 237 +W + A+T + V VA PT ++++ + + + +W D Sbjct: 236 MWLTENGAKTISFTAP-----SPVHAVAACPT---QAWICAATYEG-IAVWDIGAKQQID 286 Query: 238 NEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 Q +K + +W+ G+VL D + W+ Sbjct: 287 LVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWE 331 Score = 93.7 bits (231), Expect = 8e-20, Method: Composition-based stats. Identities = 47/280 (16%), Positives = 90/280 (32%), Gaps = 36/280 (12%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDT----LTGHEGPVWRVDWA 62 HN I +D L + S DK+ ++++ T + T L GH V V + Sbjct: 31 GHNAAIESIEIDNEHNYLVSASRDKSALVWKL-NRTQEQWATPFTRLIGHNHFVSDVSLS 89 Query: 63 HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD 122 + L + S+D + +W ++ H V V ++P ++ D Sbjct: 90 RD--ASHLLTSSWDSTLRLWDLSTRTTKKL--FLGHKKDVLGVTFSP--CNRRIISVGRD 143 Query: 123 GKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLV 182 +V + + V S + AP E G D V Sbjct: 144 NQVKIWNILGENKAELQC----SSWVTSVACAPMADETSPLV--------IAVGCWDGKV 191 Query: 183 KIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGP 242 IW +A+ L + H V ++P ++ + DR ++W +N Sbjct: 192 YIWSIEKEAK---LIKEFKAHDGRCTSVDFTPD---GKWVITGGSDRKVVMWLTENGAKT 245 Query: 243 WKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 T P + + + + + + + +W Sbjct: 246 ISFTA------PSPVHAVAACPTQAWICAATYEG-IAVWD 278 Score = 66.0 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 33/123 (26%), Positives = 50/123 (40%), Gaps = 9/123 (7%) Query: 169 ESRKFVTGGADNLVKIWKYNSDAQTYVLEST-LEGHSDWVRDVAWSPTVLLRSYLASVSQ 227 E V+ D +WK N + + T L GH+ +V DV+ S S+L + S Sbjct: 44 EHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLS---RDASHLLTSSW 100 Query: 228 DRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEG 287 D T +W KK L +K + ++S + G DN+V +W E Sbjct: 101 DSTLRLWDLSTRT--TKKLFLGHKK---DVLGVTFSPCNRRIISVGRDNQVKIWNILGEN 155 Query: 288 KWE 290 K E Sbjct: 156 KAE 158 Score = 54.0 bits (128), Expect = 7e-08, Method: Composition-based stats. Identities = 18/87 (20%), Positives = 35/87 (40%), Gaps = 3/87 (3%) Query: 198 STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVL 257 +T GH+ + + +YL S S+D++ ++W + Q W + + Sbjct: 27 ATFVGHNAAIESIEID---NEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFV 83 Query: 258 WRASWSLSGNVLALSGGDNKVTLWKEN 284 S S + L S D+ + LW + Sbjct: 84 SDVSLSRDASHLLTSSWDSTLRLWDLS 110 Score = 41.0 bits (94), Expect = 6e-04, Method: Composition-based stats. Identities = 24/136 (17%), Positives = 46/136 (33%), Gaps = 17/136 (12%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 AH+ GK + T SD+ + ++ E + T PV V + Sbjct: 207 KAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTAP---SPVHAVAACPTQ 263 Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAV---------HAVHSASVNSVQWAPHEYGPLL 116 + + +Y+G + +W + + +A + + WA G +L Sbjct: 264 A--WICAATYEG-IAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAAD--GSVL 318 Query: 117 LVASSDGKVSVVEFKE 132 +DG + E K Sbjct: 319 YSGYNDGSIRAWEVKS 334 >4J0W-A nrPDB Length = 343 Score = 103 bits (256), Expect = 9e-23, Method: Composition-based stats. Identities = 51/273 (18%), Positives = 90/273 (32%), Gaps = 37/273 (13%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H+ + + GK LA+ K I I+E ++ + + T TGH V + + + Sbjct: 65 GHSSHVLCMAISSDGKYLASGDRSKLILIWE--AQSCQHLYTFTGHRDAVSGLAFR--RG 120 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 L S S+D V +W + + H +V ++ E + DG V Sbjct: 121 THQLYSTSHDRSVKVWNVAENSY--VETLFGHQDAVAALDALSRE--CCVTAGGRDGTVR 176 Query: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 V + E S ++ H ++ V+G D V +W Sbjct: 177 VWKIPE---ESQLVFYGHQGSIDCI--------------HLINEEHMVSGADDGSVALWG 219 Query: 187 YNS--DAQTYVLESTLEGHSD-----WVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNE 239 + L G W+ VA +L +A+ S +W Sbjct: 220 LSKKRPLALQREAHGLRGEPGLEQPFWISSVA---ALLNTDLVATGSHSSCVRLW--QCG 274 Query: 240 QGPWKKTLLKEEKFPDVLWRASWSLSGNVLALS 272 +G + LL + + +S SG+ L Sbjct: 275 EGFRQLDLLCDIPLVGFINSLKFSSSGDFLVAG 307 Score = 96.4 bits (238), Expect = 1e-20, Method: Composition-based stats. Identities = 50/296 (16%), Positives = 98/296 (33%), Gaps = 45/296 (15%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE-GETHKLIDTLT--------GH 52 + + H I V+ + + + D +I + VE G +I GH Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 66 Query: 53 EGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEY 112 V + + G LAS +LIW+ ++ + H +V+ + + + Sbjct: 67 SSHVLCMAISSD--GKYLASGDRSKLILIWEAQS--CQHLYTFTGHRDAVSGLAFRRGTH 122 Query: 113 GPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRK 172 S D V V EN + H V + + Sbjct: 123 QLY--STSHDRSVKVWNVAENSYVETLF--GHQDAVAAL-------------DALSRECC 165 Query: 173 FVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 232 GG D V++WK ++Q GH + + ++ ++ S + D + Sbjct: 166 VTAGGRDGTVRVWKIPEESQL-----VFYGHQGSIDCI----HLINEEHMVSGADDGSVA 216 Query: 233 IWTQDNEQGPWKKT----LLKEEKFPDVLWRASWS--LSGNVLALSGGDNKVTLWK 282 +W ++ + L E W +S + L+ +++A + V LW+ Sbjct: 217 LWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQ 272 Score = 78.3 bits (191), Expect = 3e-15, Method: Composition-based stats. Identities = 39/232 (16%), Positives = 85/232 (36%), Gaps = 23/232 (9%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 H + + +L + S D+++K++ V + ++TL GH+ V +D + Sbjct: 106 TGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENS--YVETLFGHQDAVAALDALSRE 163 Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 + + DG V +WK V H S++ + E+ + + DG V Sbjct: 164 C--CVTAGGRDGTVRVWKIPE---ESQLVFYGHQGSIDCIHLINEEHM---VSGADDGSV 215 Query: 126 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 ++ + + + +AH + P I T TG + V++W Sbjct: 216 ALWGLSKKRPLA-LQREAHGLRGEPGLEQPFWISSVAALLNTD---LVATGSHSSCVRLW 271 Query: 186 KYNSDAQ--TYVLESTLEGHSDWVRDVAWSPTVLLRSYLASV-SQDRTCIIW 234 + + + + L G ++ + +S + +L + Q+ W Sbjct: 272 QCGEGFRQLDLLCDIPLVG---FINSLKFSSS---GDFLVAGVGQEHRLGRW 317 >6BX3-A nrPDB Length = 314 Score = 102 bits (253), Expect = 3e-22, Method: Composition-based stats. Identities = 47/235 (20%), Positives = 90/235 (38%), Gaps = 21/235 (8%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H + + G L T S D++IKI++ L+ T++ H V VD Sbjct: 93 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDT--LNGSLMKTISAHSEAVVSVD-VPMND 149 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSA------SVNSVQWAPHEYGPLLLVAS 120 +IL+S SYDG + I+ E G + + ++ V+++ E LLV S Sbjct: 150 SSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFS--ENARYLLVKS 207 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 DG V + + + GV + D + + ++G + Sbjct: 208 LDGVVKIWDCIGGCVVRTFQVQPLEKGVLH-----HSCGMDFLNPEDGSTPLVISGYENG 262 Query: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 + W ++ + +L+ +L HS V + + + S++ + C +W Sbjct: 263 DIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHC-----FGNIMCSLALNGDCCLWR 312 Score = 101 bits (251), Expect = 4e-22, Method: Composition-based stats. Identities = 55/286 (19%), Positives = 100/286 (34%), Gaps = 25/286 (8%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 + +H + G+ +AT S D ++ E+ ++ L+ T GH PV + + Sbjct: 47 QTLVTSHARPFSELCWSPDGQCIATASDDFSV---EIIHLSYGLLHTFIGHTAPVISLTF 103 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 + G +L + S D + IW NG + + HS +V SV P +L S Sbjct: 104 N--RKGNLLFTSSMDESIKIWDTLNGSLMK--TISAHSEAVVSVD-VPMNDSSILSSGSY 158 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 DG + + + + + D N + ++ +R + D + Sbjct: 159 DGLIRIFDAETGHCLKTLTYDKDWKRENGVV-------PISQVKFSENARYLLVKSLDGV 211 Query: 182 VKIWKYNSDA-----QTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ 236 VKIW Q LE + HS + + +P + S ++ W Sbjct: 212 VKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFL--NPEDGSTPLVISGYENGDIYCWNS 269 Query: 237 DNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 D + LL + S GN++ + LW+ Sbjct: 270 DTKS---LLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLWR 312 Score = 44.4 bits (103), Expect = 7e-05, Method: Composition-based stats. Identities = 19/115 (16%), Positives = 40/115 (34%), Gaps = 12/115 (10%) Query: 168 KESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQ 227 +F+ + I+ N + V ++ + H+ ++ WSP +A+ S Sbjct: 21 SPDGQFLAITQGLNILIYDIN---RRTVSQTLVTSHARPFSELCWSPD---GQCIATASD 74 Query: 228 DRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 D + I L + +++ GN+L S D + +W Sbjct: 75 DFSVEIIHLSYG------LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD 123 >3ODT-A nrPDB Length = 313 Score = 101 bits (251), Expect = 4e-22, Method: Composition-based stats. Identities = 60/290 (20%), Positives = 111/290 (38%), Gaps = 52/290 (17%) Query: 12 IHDAVLDYYGKRLATCSSDKTIK---IFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGT 68 ++ D + L D I +F GE + TL GH+G V + + Sbjct: 62 LNSVCYDSEKELLLFGGKDTMINGVPLFATSGEDP--LYTLIGHQGNVCSLSF----QDG 115 Query: 69 ILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNS---VQWAPHEYGPLLLVASSDGKV 125 ++ S S+D +WKE + + H+ASV V ++ ++ L AS+D + Sbjct: 116 VVISGSWDKTAKVWKEGS----LVYNLQAHNASVWDAKVVSFSENK----FLTASADKTI 167 Query: 126 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 + + + T I H V + + F++ D L+K+ Sbjct: 168 KLWQNDKVIKTFSGI---HNDVVRHLA--------------VVDDGHFISCSNDGLIKL- 209 Query: 186 KYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKK 245 D T + T EGH +V + P + S +DRT IW+++N G K+ Sbjct: 210 ---VDMHTGDVLRTYEGHESFVYCIKLLPNGD----IVSCGEDRTVRIWSKEN--GSLKQ 260 Query: 246 TLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEV 295 + +W +G+++ DN V ++ + + +W E+ Sbjct: 261 VITLPAI---SIWSVDCMSNGDIIV-GSSDNLVRIFSQE-KSRWASEDEI 305 Score = 75.2 bits (183), Expect = 3e-14, Method: Composition-based stats. Identities = 44/247 (17%), Positives = 84/247 (34%), Gaps = 43/247 (17%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWR---VDWAH 63 H + L + + + S DKT K+++ L+ L H VW V ++ Sbjct: 102 GHQGNV--CSLSFQDGVVISGSWDKTAKVWK----EGSLVYNLQAHNASVWDAKVVSFSE 155 Query: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 K + S D + +W +N + + +H+ V + + + S+DG Sbjct: 156 NK----FLTASADKTIKLW--QNDKVIKTFS-GIHNDVVRHLAVVDDGH---FISCSNDG 205 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 + +V+ + H V P + V+ G D V+ Sbjct: 206 LIKLVDMHTGDVLRTY--EGHESFVYCIKLLP--------------NGDIVSCGEDRTVR 249 Query: 184 IWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPW 243 IW + + V+ TL S WS + + S D I++Q+ + Sbjct: 250 IWSKENGSLKQVI--TLPAIS------IWSVDCMSNGDIIVGSSDNLVRIFSQEKSRWAS 301 Query: 244 KKTLLKE 250 + + E Sbjct: 302 EDEIKGE 308 >2P9P-C nrPDB Length = 372 Score = 101 bits (250), Expect = 5e-22, Method: Composition-based stats. Identities = 50/246 (20%), Positives = 79/246 (32%), Gaps = 36/246 (14%) Query: 10 ELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTI 69 E I + ++A C ++ + I+E G + L H G V VDWA Sbjct: 9 EPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPD--SNR 66 Query: 70 LASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVE 129 + +C D +W + W V + + V+WAP+E V S +S+ Sbjct: 67 IVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNE--KKFAVGSGSRVISICY 124 Query: 130 FKENGTTS--PIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK- 186 F++ I V S W P ++ G D +I+ Sbjct: 125 FEQENDWWVCKHIKKPIRSTVLSLDWHPNSV-------------LLAAGSCDFKCRIFSA 171 Query: 187 -------------YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII 233 + S L WV V +S S +A VS D T + Sbjct: 172 YIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSAN---GSRVAWVSHDSTVCL 228 Query: 234 WTQDNE 239 D + Sbjct: 229 ADADKK 234 Score = 72.2 bits (175), Expect = 2e-13, Method: Composition-based stats. Identities = 45/248 (18%), Positives = 79/248 (31%), Gaps = 42/248 (16%) Query: 55 PVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGP 114 P+ W + T +A C + +V I+++ +W Q+ H+ V V WAP Sbjct: 10 PISCHAWNKDR--TQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPD--SN 65 Query: 115 LLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFV 174 ++ +D V K ++I WAP +KF Sbjct: 66 RIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAP-------------NEKKFA 112 Query: 175 TGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII- 233 G ++ I + + +V + + V + W P +L LA+ S D C I Sbjct: 113 VGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVL---LAAGSCDFKCRIF 169 Query: 234 ---------------WTQDNEQGPWKKT------LLKEEKFPDVLWRASWSLSGNVLALS 272 W G + F R +W + + L+ Sbjct: 170 SAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLA 229 Query: 273 GGDNKVTL 280 D K+ + Sbjct: 230 DADKKMAV 237 Score = 65.6 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 41/241 (17%), Positives = 82/241 (34%), Gaps = 13/241 (5%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 HN + R+ TC +D+ ++ ++G T K + V WA Sbjct: 48 LKEHNGQVTGVDWAPDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPN 107 Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 + + S S + +++EN W + ++V S+ W P+ LL S D K Sbjct: 108 EKKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPN--SVLLAAGSCDFK 165 Query: 125 VSVV--EFKENGTTSPIIIDAHAIGVNSASW-APATIEEDGEHNGTKESRKFVTGGADNL 181 + KE + + + ++ + + D+ Sbjct: 166 CRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDST 225 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQG 241 V + DA + +TL + + V + + S L + D +++T D+ G Sbjct: 226 VCLA----DADKKMAVATLASETLPLLAVTF----ITESSLVAAGHDCFPVLFTYDSAAG 277 Query: 242 P 242 Sbjct: 278 K 278 Score = 50.2 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 25/138 (18%), Positives = 52/138 (37%), Gaps = 8/138 (5%) Query: 152 SWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVA 211 ++ +E H K+ + ++ V I++ + + +V L+ H+ V V Sbjct: 2 AYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGN--KWVQVHELKEHNGQVTGVD 59 Query: 212 WSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLAL 271 W+P + + + DR +WT WK TL+ + W+ + A+ Sbjct: 60 WAPD---SNRIVTCGTDRNAYVWTLKGRT--WKPTLVIL-RINRAARCVRWAPNEKKFAV 113 Query: 272 SGGDNKVTLWKENLEGKW 289 G +++ E W Sbjct: 114 GSGSRVISICYFEQENDW 131 Score = 36.3 bits (82), Expect = 0.016, Method: Composition-based stats. Identities = 16/91 (17%), Positives = 34/91 (37%), Gaps = 6/91 (6%) Query: 203 HSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASW 262 HS V ++ R+ +A + I+ + G + + ++ + W Sbjct: 4 HSFLVEPISCHAWNKDRTQIAICPNNHEVHIYE---KSGNKWVQVHELKEHNGQVTGVDW 60 Query: 263 SLSGNVLALSGGDNKVTLWKENLEGK-WEPA 292 + N + G D +W L+G+ W+P Sbjct: 61 APDSNRIVTCGTDRNAYVW--TLKGRTWKPT 89 >4A11-B nrPDB Length = 408 Score = 100 bits (249), Expect = 6e-22, Method: Composition-based stats. Identities = 51/253 (20%), Positives = 85/253 (33%), Gaps = 45/253 (17%) Query: 52 HEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEEN------GRWSQIAVHAV-----HSA 100 H G + +D P G + S DG ++++ EN + H Sbjct: 42 HGGGINTLD-IEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRY 100 Query: 101 SVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEE 160 SV +VQW PH+ G + +S D + V + T + V S +P + + Sbjct: 101 SVETVQWYPHDTG-MFTSSSFDKTLKVWDTNTLQTADVFNFEET---VYSHHMSPVSTKH 156 Query: 161 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRS 220 GT+ + + D ++ L+GH + V+WSP Sbjct: 157 CLVAVGTRGPKVQLC--------------DLKSGSCSHILQGHRQEILAVSWSP--RYDY 200 Query: 221 YLASVSQDRTCIIWTQDNEQGPWKKTLLKEEK------------FPDVLWRASWSLSGNV 268 LA+ S D +W G TL + + ++ G Sbjct: 201 ILATASADSRVKLWDVRRASG-CLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLH 259 Query: 269 LALSGGDNKVTLW 281 L G DN++ LW Sbjct: 260 LLTVGTDNRMRLW 272 Score = 98.0 bits (242), Expect = 4e-21, Method: Composition-based stats. Identities = 46/259 (17%), Positives = 92/259 (35%), Gaps = 46/259 (17%) Query: 8 HNELIHDAVLDY-YGKRLATCSSDKTIKIFEVEGETHKLIDTLTG-----------HEGP 55 H I+ ++ G+ + + SD I ++++E + + T H Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 56 VWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAP-HEYGP 114 V V W +P + S S+D + +W + + + +V S +P Sbjct: 102 VETVQW-YPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFE---ETVYSHHMSPVSTKHC 157 Query: 115 LLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFV 174 L+ V + KV + + K + I+ H + + SW+P + Sbjct: 158 LVAVGTRGPKVQLCDLKSGSCS--HILQGHRQEILAVSWSP------------RYDYILA 203 Query: 175 TGGADNLVKIWKYN------------SDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYL 222 T AD+ VK+W + ++ +ES H+ V + ++ L +L Sbjct: 204 TASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGL---HL 260 Query: 223 ASVSQDRTCIIWTQDNEQG 241 +V D +W N + Sbjct: 261 LTVGTDNRMRLWNSSNGEN 279 Score = 56.7 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 40/199 (20%), Positives = 67/199 (33%), Gaps = 39/199 (19%) Query: 98 HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDA-----------HAI 146 H +N++ P E G +L SDG + + + + + S A H Sbjct: 42 HGGGINTLDIEPVE-GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRY 100 Query: 147 GVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN--SDAQTYVLESTLEGHS 204 V + W P ++ F + D +K+W N A + E T+ H Sbjct: 101 SVETVQWYPH------------DTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSH- 147 Query: 205 DWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSL 264 SP +A + R + D + G L + + SWS Sbjct: 148 ------HMSPVSTKHCLVAVGT--RGPKVQLCDLKSGSCSHILQGHRQ---EILAVSWSP 196 Query: 265 -SGNVLALSGGDNKVTLWK 282 +LA + D++V LW Sbjct: 197 RYDYILATASADSRVKLWD 215 Score = 40.2 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 21/132 (15%), Positives = 41/132 (31%), Gaps = 21/132 (15%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 AHN ++ G L T +D ++++ + L+ G +V K Sbjct: 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLV--NYG------KVCNNSKK 293 Query: 66 FGTILASCS---------YDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLL 116 SC Y + ++ +G QI + H +V+ + + Sbjct: 294 GLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGE--QITMLKGHYKTVDCCVFQSNFQELY- 350 Query: 117 LVASSDGKVSVV 128 S D + Sbjct: 351 -SGSRDCNILAW 361 Score = 38.3 bits (87), Expect = 0.004, Method: Composition-based stats. Identities = 15/91 (16%), Positives = 27/91 (29%), Gaps = 11/91 (12%) Query: 203 HSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGP----WKKTLLKEEKFPDV-- 256 H + + P + Y+ S D +++ +N K PDV Sbjct: 42 HGGGINTLDIEP--VEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 Query: 257 --LWRASWSL-SGNVLALSGGDNKVTLWKEN 284 + W + S D + +W N Sbjct: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTN 130 Score = 31.3 bits (69), Expect = 0.53, Method: Composition-based stats. Identities = 6/35 (17%), Positives = 13/35 (37%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIF 36 + + H + + V + L + S D I + Sbjct: 327 ITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 >5WYK-BB nrPDB Length = 943 Score = 100 bits (249), Expect = 7e-22, Method: Composition-based stats. Identities = 62/311 (19%), Positives = 111/311 (35%), Gaps = 53/311 (17%) Query: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE-------GETHKLIDTLTGH--- 52 I +AH+ I L GKRL T S+DKT+K ++ + G +K + L H Sbjct: 467 TIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDT 526 Query: 53 ----EGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWA 108 + V + LA D V ++ ++ ++ H V S+ + Sbjct: 527 TLELTDDILCVRVSPDD--RYLAISLLDNTVKVFFLDSMKF--YLSLYGHKLPVLSIDIS 582 Query: 109 PHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTK 168 +++ +S+D + + + AH + + + P + Sbjct: 583 FD--SKMIITSSADKNIKIWGLDFGDC--HKSLFAHQDSIMNVKFLPQSHN--------- 629 Query: 169 ESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQD 228 F + D +VK W D + + L H V +A + ++ S S D Sbjct: 630 ----FFSCSKDAVVKYW----DGEKFECIQKLYAHQSEVWALAVA---TDGGFVVSSSHD 678 Query: 229 RTCIIW--TQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLE 286 + IW T+D +K EE++ D L + L GD+ + E Sbjct: 679 HSIRIWEETEDQVFLEEEKEKELEEQYEDTLLTS--------LEEGNGDDAFKA-DASGE 729 Query: 287 GKWEPAGEVHQ 297 G + A VH+ Sbjct: 730 GVEDEASGVHK 740 Score = 87.9 bits (216), Expect = 4e-18, Method: Composition-based stats. Identities = 39/230 (16%), Positives = 72/230 (31%), Gaps = 40/230 (17%) Query: 67 GTILASCSYDGKVLIWKEENG--------RWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 118 G ++ S D V IW + G A A + H+ LL V Sbjct: 39 GQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAV 96 Query: 119 ASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGA 178 +DG + V + T + + H + + + ++G Sbjct: 97 GYADGVIKVWDLMSK--TVLLNFNGHKAAITLLQFD-------------GTGTRLISGSK 141 Query: 179 DNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDN 238 D+ + +W + Y L H D + W +L S S+D +W Sbjct: 142 DSNIIVWDLVGEVGLYK----LRSHKDSITGF-WC---QGEDWLISTSKDGMIKLWDL-- 191 Query: 239 EQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGK 288 + + W + +L +G D++V +WK ++E Sbjct: 192 ---KTHQCIETHIAHTGECWGLAVKDD--LLITTGTDSQVKIWKLDIEND 236 Score = 79.1 bits (193), Expect = 2e-15, Method: Composition-based stats. Identities = 43/277 (15%), Positives = 85/277 (30%), Gaps = 48/277 (17%) Query: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTL-----------TGHEGPVWRVDWAHPKFGTI 69 G+ + + D + I++++ T L+ L G P K + Sbjct: 39 GQLITSALED--VNIWDIK--TGDLVSKLSDGLPPGASDARG-AKPAECTYLEAHKDTDL 93 Query: 70 LASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVE 129 LA DG + +W + + H A++ +Q+ G L+ S D + V + Sbjct: 94 LAVGYADGVIKVWDLMSKTV--LLNFNGHKAAITLLQF--DGTGTRLISGSKDSNIIVWD 149 Query: 130 FKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNS 189 G + +H + W + ++ D ++K+W Sbjct: 150 L--VGEVGLYKLRSHKDSITG-FWC-------------QGEDWLISTSKDGMIKLW---- 189 Query: 190 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLK 249 D +T+ T H+ +A L + D IW D E L + Sbjct: 190 DLKTHQCIETHIAHTGECWGLAV-----KDDLLITTGTDSQVKIWKLDIENDKMGGKLTE 244 Query: 250 EEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLE 286 F + + + D + +N + Sbjct: 245 MGIFEKQSKQRGLKIE---FITNSSDKTSFFYIQNAD 278 Score = 74.8 bits (182), Expect = 4e-14, Method: Composition-based stats. Identities = 47/247 (19%), Positives = 88/247 (35%), Gaps = 41/247 (16%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 AH + LA +D IK++++ +T ++ GH+ + + + Sbjct: 85 LEAHKDT----------DLLAVGYADGVIKVWDLMSKT--VLLNFNGHKAAITLLQF--D 130 Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 GT L S S D +++W + H S+ W + L+ S DG Sbjct: 131 GTGTRLISGSKDSNIIVWDLVG--EVGLYKLRSHKDSITGF-WC--QGEDWLISTSKDGM 185 Query: 125 VSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 + + + K + I AH + + +T G D+ VKI Sbjct: 186 IKLWDLKTHQCIETHI--AHTGECWGLA---------------VKDDLLITTGTDSQVKI 228 Query: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 244 WK + + + T G + + S L+ + S D+T + Q+ ++ Sbjct: 229 WKLDIENDKMGGKLTEMG----IFEKQ-SKQRGLKIEFITNSSDKTSFFYIQNADKTIET 283 Query: 245 KTLLKEE 251 + KEE Sbjct: 284 FRIRKEE 290 Score = 41.7 bits (96), Expect = 3e-04, Method: Composition-based stats. Identities = 23/136 (16%), Positives = 39/136 (28%), Gaps = 15/136 (11%) Query: 152 SWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRD-- 209 W PA+ G NG+ + + D V IW + L L + R Sbjct: 24 VWIPAS---SGNSNGSGPGQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAK 78 Query: 210 ---VAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSG 266 + LA D +W ++ LL + + +G Sbjct: 79 PAECTYLEAHKDTDLLAVGYADGVIKVWDLMSKT-----VLLNFNGHKAAITLLQFDGTG 133 Query: 267 NVLALSGGDNKVTLWK 282 L D+ + +W Sbjct: 134 TRLISGSKDSNIIVWD 149 Score = 35.9 bits (81), Expect = 0.018, Method: Composition-based stats. Identities = 8/37 (21%), Positives = 16/37 (43%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFE 37 + AH + + G + + S D +I+I+E Sbjct: 649 CIQKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWE 685 >4G56-B nrPDB Length = 357 Score = 100 bits (249), Expect = 7e-22, Method: Composition-based stats. Identities = 44/225 (19%), Positives = 81/225 (36%), Gaps = 25/225 (11%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 H++++ + G + + D ++K++++ ++ + H V V A P Sbjct: 138 HDDIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQ--KAVLKSYNAHSSEVNCVA-ACPGKD 194 Query: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 TI SC DG++L+W + + SV W P + G VS+ Sbjct: 195 TIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKD-DTFACGDETGNVSL 253 Query: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 V K + + H+ + +++ + + D V + Sbjct: 254 VNIKNPDSAQTSAV--HSQNITGLAYSYHSSPF------------LASISEDCTVAV--- 296 Query: 188 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 232 DA + L H D+V VAWSP L S +V D + Sbjct: 297 -LDADFSEVFRDL-SHRDFVTGVAWSP--LDHSKFTTVGWDHKVL 337 Score = 74.8 bits (182), Expect = 4e-14, Method: Composition-based stats. Identities = 47/273 (17%), Positives = 91/273 (33%), Gaps = 33/273 (12%) Query: 9 NELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTL--TGHEGPVWRVDWAHPKF 66 + D L S ++++E+ + L++ H+ V + Sbjct: 94 EAGVTDVAWVSEKGILV-ASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSD-- 150 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 GT S D V +W + + HS+ VN V P + + L DG++ Sbjct: 151 GTQAVSGGKDFSVKVWDLSQKAVLKS--YNAHSSEVNCVAACPGKD-TIFLSCGEDGRIL 207 Query: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 + + ++ + I A S +W P + + T Sbjct: 208 LWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLV------------- 254 Query: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT 246 + + T HS + +A+S +LAS+S+D T + D + Sbjct: 255 ---NIKNPDSAQTSAVHSQNITGLAYSYH--SSPFLASISEDCTVAVLDADFSE------ 303 Query: 247 LLKEEKFPDVLWRASWSL-SGNVLALSGGDNKV 278 + ++ D + +WS + G D+KV Sbjct: 304 VFRDLSHRDFVTGVAWSPLDHSKFTTVGWDHKV 336 Score = 53.7 bits (127), Expect = 9e-08, Method: Composition-based stats. Identities = 40/223 (17%), Positives = 72/223 (32%), Gaps = 27/223 (12%) Query: 77 GKVLIWKEENGRWSQIAVHAV--HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENG 134 G + ++K+ G ++ A A V V W + +LVAS G V + E E Sbjct: 70 GSIWVFKDPEGAPNESLCTAGVQTEAGVTDVAWVSEKG---ILVASDSGAVELWEILEKE 126 Query: 135 TTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTY 194 + + + + + + V+GG D VK+W D Sbjct: 127 SLLVNKFAKYEHD-----------DIVKTLSVFSDGTQAVSGGKDFSVKVW----DLSQK 171 Query: 195 VLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFP 254 + + HS V VA P + S +D ++W + + + P Sbjct: 172 AVLKSYNAHSSEVNCVAACPGK--DTIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIP 229 Query: 255 DVLWRASWSLSGNVLALSGGDNKVTLWKENLEG-KWEPAGEVH 296 +W + + GD + N++ VH Sbjct: 230 T---SVTWHPEKDD-TFACGDETGNVSLVNIKNPDSAQTSAVH 268 >5WBU-D nrPDB Length = 328 Score = 100 bits (248), Expect = 8e-22, Method: Composition-based stats. Identities = 42/282 (14%), Positives = 93/282 (32%), Gaps = 32/282 (11%) Query: 8 HNEL-IHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H + ++ + +A + I+++++ I + G + V + + Sbjct: 42 HQDSQVNALEVTPDRSMIAAAGY-QHIRMYDLNSNNPNPIISYDGVNKNIASVGFH--ED 98 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 G + + D IW + + V +A +N V P++ L+V G + Sbjct: 99 GRWMYTGGEDCTARIWDLRSRNLQCQRIFQV-NAPINCVCLHPNQAE--LIVGDQSGAIH 155 Query: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 + + K + I P + ++ + +W Sbjct: 156 IWDLKTDHNEQLI---------------PEPEVSITSAHIDPDASYMAAVNSTGNCYVWN 200 Query: 187 YN----SDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGP 242 + + ++ + H+ + +SP L LA+ S D+TC IW N Sbjct: 201 LTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTL---LATCSADQTCKIWRTSNFSLM 257 Query: 243 WKKTLLKE---EKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 + ++ E +W ++S + + DN LW Sbjct: 258 TELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 299 Score = 89.5 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 41/251 (16%), Positives = 75/251 (29%), Gaps = 23/251 (9%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 + N+ I G+ + T D T +I+++ + P+ V HP Sbjct: 84 DGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV-NAPINCVCL-HPN 141 Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 ++ G + IW + Q+ V+ + +S G Sbjct: 142 QAELIV-GDQSGAIHIWDLKTDHNEQLIP----EPEVSITSAHIDPDASYMAAVNSTGNC 196 Query: 126 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 V + PA + + +S T AD KIW Sbjct: 197 YVWNLTGGIGDEVTQLIPKTK-------IPAHTRYALQCRFSPDSTLLATCSADQTCKIW 249 Query: 186 KYNSDAQTYVLE----STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQG 241 + ++ + L + E W+ A+S Y+ + S D +W E G Sbjct: 250 RTSNFSLMTELSIKSGNPGESSRGWMWGCAFS---GDSQYIVTASSDNLARLWC--VETG 304 Query: 242 PWKKTLLKEEK 252 K+ +K Sbjct: 305 EIKREYGGHQK 315 Score = 84.9 bits (208), Expect = 4e-17, Method: Composition-based stats. Identities = 38/262 (14%), Positives = 85/262 (32%), Gaps = 31/262 (11%) Query: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 LAT D T++ + + + T+ + V ++ + +++A+ Y + ++ Sbjct: 17 LATAGYDHTVRFW--QAHSGICTRTVQHQDSQVNALEVTPDR--SMIAAAGY-QHIRMYD 71 Query: 84 EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDA 143 + + I + + ++ SV + HE G + D + + + I Sbjct: 72 LNSNNPNPIISYDGVNKNIASVGF--HEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 129 Query: 144 HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGH 203 +N P + + G + IW +D ++ Sbjct: 130 -NAPINCVCLHP-------------NQAELIVGDQSGAIHIWDLKTDHNEQLIPEP---- 171 Query: 204 SDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEK---FPDVLWRA 260 + P SY+A+V+ C +W G L+ + K + Sbjct: 172 EVSITSAHIDPDA---SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQC 228 Query: 261 SWSLSGNVLALSGGDNKVTLWK 282 +S +LA D +W+ Sbjct: 229 RFSPDSTLLATCSADQTCKIWR 250 Score = 66.0 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 20/110 (18%), Positives = 37/110 (33%), Gaps = 10/110 (9%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHE------GPVWR 58 AH LATCS+D+T KI+ + ++ G +W Sbjct: 218 IPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWG 277 Query: 59 VDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWA 108 ++ + + S D +W E G + + H +V + + Sbjct: 278 CAFSGD--SQYIVTASSDNLARLWCVETGEIKR--EYGGHQKAVVCLAFN 323 Score = 44.8 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 16/122 (13%), Positives = 39/122 (31%), Gaps = 11/122 (9%) Query: 161 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRS 220 + T G D+ V+ W+ +S + T++ V + +P RS Sbjct: 5 TSPGTVGSDPVILATAGYDHTVRFWQAHS----GICTRTVQHQDSQVNALEVTPD---RS 57 Query: 221 YLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTL 280 +A+ ++ ++ ++ + + + G + G D + Sbjct: 58 MIAAAGYQH-IRMYDLNSNNPNP---IISYDGVNKNIASVGFHEDGRWMYTGGEDCTARI 113 Query: 281 WK 282 W Sbjct: 114 WD 115 >3DWL-C nrPDB Length = 377 Score = 98.3 bits (243), Expect = 4e-21, Method: Composition-based stats. Identities = 53/264 (20%), Positives = 96/264 (36%), Gaps = 19/264 (7%) Query: 16 VLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSY 75 + T ++ ++++E +G K T + H+ V VDWA PK + +CS Sbjct: 18 AFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWA-PKSNR-IVTCSQ 75 Query: 76 DGKVLIWKEE-NGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENG 134 D ++++ +G W Q V + + V+W+P+E V S +SV F++ Sbjct: 76 DRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNE--DKFAVGSGARVISVCYFEQEN 133 Query: 135 TT--SPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK----IWKYN 188 S + + S W P + +++ D K +W Sbjct: 134 DWWVSKHLKRPLRSTILSLDWHPNNV-LLAAGCADRKAYVLSAYVRDVDAKPEASVWGSR 192 Query: 189 SDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLL 248 T E G WV V +SP+ + LA D + I + P + L+ Sbjct: 193 LPFNTVCAEYPSGG---WVHAVGFSPS---GNALAYAGHDSSVTIAYPSAPEQPPRA-LI 245 Query: 249 KEEKFPDVLWRASWSLSGNVLALS 272 + L W+ ++A Sbjct: 246 TVKLSQLPLRSLLWANESAIVAAG 269 Score = 62.1 bits (149), Expect = 3e-10, Method: Composition-based stats. Identities = 30/182 (16%), Positives = 63/182 (34%), Gaps = 5/182 (2%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGE-THKLIDTLTGHEGPVWRVDWAHP 64 + H++++ R+ TCS D+ ++E + T K L V W+ Sbjct: 52 SDHDKIVTCVDWAPKSNRIVTCSQDRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPN 111 Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 + + S + V +++EN W + +++ S+ W P+ LL +D K Sbjct: 112 EDKFAVGSGARVISVCYFEQENDWWVSKHLKRPLRSTILSLDWHPN--NVLLAAGCADRK 169 Query: 125 VSVV--EFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLV 182 V+ ++ + + N+ + + G D+ V Sbjct: 170 AYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEYPSGGWVHAVGFSPSGNALAYAGHDSSV 229 Query: 183 KI 184 I Sbjct: 230 TI 231 Score = 59.8 bits (143), Expect = 1e-09, Method: Composition-based stats. Identities = 40/215 (18%), Positives = 73/215 (33%), Gaps = 31/215 (14%) Query: 79 VLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTT-S 137 V +++++ W + H V V WAP ++ S D V E + +GT Sbjct: 35 VELYEQDGNGWKHARTFSDHDKIVTCVDWAPK--SNRIVTCSQDRNAYVYEKRPDGTWKQ 92 Query: 138 PIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLE 197 +++ W+P KF G ++ + + + +V + Sbjct: 93 TLVLLRLNRAATFVRWSP-------------NEDKFAVGSGARVISVCYFEQENDWWVSK 139 Query: 198 STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKK------------ 245 + + W P +L LA+ DR + + K Sbjct: 140 HLKRPLRSTILSLDWHPNNVL---LAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFN 196 Query: 246 TLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTL 280 T+ E + +S SGN LA +G D+ VT+ Sbjct: 197 TVCAEYPSGGWVHAVGFSPSGNALAYAGHDSSVTI 231 Score = 47.9 bits (112), Expect = 5e-06, Method: Composition-based stats. Identities = 32/165 (19%), Positives = 50/165 (30%), Gaps = 18/165 (10%) Query: 116 LLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVT 175 + ++ +V + E NG H V WAP +S + VT Sbjct: 26 FVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAP-------------KSNRIVT 72 Query: 176 GGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 D +++ D T+ L + V WSP A S R + Sbjct: 73 CSQDRNAYVYEKRPDG-TWKQTLVLLRLNRAATFVRWSPNEDK---FAVGSGARVISVCY 128 Query: 236 QDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTL 280 + E W LK + W + +LA D K + Sbjct: 129 FEQENDWWVSKHLKRP-LRSTILSLDWHPNNVLLAAGCADRKAYV 172 Score = 32.9 bits (73), Expect = 0.19, Method: Composition-based stats. Identities = 10/75 (13%), Positives = 26/75 (34%), Gaps = 3/75 (4%) Query: 216 VLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGD 275 R+ + + ++ QD +T +K + W+ N + D Sbjct: 20 NSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKI---VTCVDWAPKSNRIVTCSQD 76 Query: 276 NKVTLWKENLEGKWE 290 ++++ +G W+ Sbjct: 77 RNAYVYEKRPDGTWK 91 >3W15-A nrPDB Length = 368 Score = 96.4 bits (238), Expect = 1e-20, Method: Composition-based stats. Identities = 60/319 (18%), Positives = 106/319 (33%), Gaps = 62/319 (19%) Query: 9 NELIHDAVLD-YYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 + + D + + ++ D T+++F+ + I HE V+ +W Sbjct: 62 QDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFP-IAIFKEHEREVFSCNWNLVNRQ 120 Query: 68 TILASCSYDGKVLIW----------------------KEENGRWSQIAVHAVHSASVNSV 105 L S S+DG + IW N + S + N V Sbjct: 121 NFL-SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCV 179 Query: 106 ---QWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDG 162 Q++PH+ L+L S + S+ + + + H+ G+ + + Sbjct: 180 YQAQFSPHD-QNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHS-GLEALTCDFNKYRP-- 235 Query: 163 EHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLE-------GHSDWVRDVAWSPT 215 TGG DN ++IW + H +R V WSP Sbjct: 236 --------YVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPH 287 Query: 216 VLLRSYLASVSQDRTCIIWTQDNEQG-----------PWKKTLLKEEKFPDVLWRASWSL 264 + L S S D TC IW + G K ++ + + ++ A WSL Sbjct: 288 --HSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSL 345 Query: 265 SGN--VLALSGGDNKVTLW 281 G +A + D + +W Sbjct: 346 WGKPGYVASTAWDGNLFVW 364 Score = 79.9 bits (195), Expect = 1e-15, Method: Composition-based stats. Identities = 43/281 (15%), Positives = 85/281 (30%), Gaps = 61/281 (21%) Query: 2 VVIANAHNELIHDAVLDYYGKR-LATCSSDKTIKIFE-VEGETHKLI------------- 46 + I H + + ++ + S D +IKI+ + ++ + Sbjct: 99 IAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDP 158 Query: 47 --------DTLTGHEGPVWRVDWA--HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHA 96 + TG V A P ++ SCS + ++ Sbjct: 159 LNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFL 218 Query: 97 VHSA-SVNSVQWAPHEYGPLLLVASSDGKVSVVEFK---------ENGTTSPIIIDAHAI 146 VHS + + ++ D + + + + N + I +AH + Sbjct: 219 VHSGLEALTCDFN-KYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGL 277 Query: 147 GVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW---KYNSDAQTYVLEST---- 199 + +W+P S ++ D +IW + +TY ST Sbjct: 278 AIRKVTWSPH------------HSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATK 325 Query: 200 -----LEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 HS++V WS Y+AS + D +W Sbjct: 326 GSIFNFTQHSEFVFGADWSLWGKPG-YVASTAWDGNLFVWN 365 Score = 60.2 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 31/245 (12%), Positives = 73/245 (29%), Gaps = 26/245 (10%) Query: 59 VDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 118 + W +L + DG + ++ + IA+ H V S W L Sbjct: 68 LAWNESHENQVLVAQG-DGTLRLFDTTFKEF-PIAIFKEHEREVFSCNWNL-VNRQNFLS 124 Query: 119 ASSDGKVSVVE----------FKENGTTSPIIIDAHAIGVNSASW---APATIEEDGEHN 165 +S DG + + + ++ +AI + S+ + Sbjct: 125 SSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQF 184 Query: 166 GTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASV 225 + ++ ++ ++ + ++ HS + + +A+ Sbjct: 185 SPHDQNLVLSCSGNSYASLFDIRLPS--GKNQNNFLVHSG-LEALTCDFNKYRPYVVATG 241 Query: 226 SQDRTCIIWT---QDNEQGPWKKTLLKEEK---FPDVLWRASWSLS-GNVLALSGGDNKV 278 D IW + G + E + + +WS N+L + D Sbjct: 242 GVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTC 301 Query: 279 TLWKE 283 +W++ Sbjct: 302 RIWRD 306 >6ELZ-p nrPDB Length = 460 Score = 94.5 bits (233), Expect = 5e-20, Method: Composition-based stats. Identities = 52/337 (15%), Positives = 106/337 (31%), Gaps = 88/337 (26%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKL-------------------- 45 + H+ I RL + +D+T+++++ + + KL Sbjct: 141 SGHSGPIRAVKY-ISNTRLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGK 199 Query: 46 -IDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWS-------------- 90 + L GH+ PV +D + + + S SYD + W + Sbjct: 200 TLAILEGHKAPVVSIDVS---DNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNK 256 Query: 91 ----------------------QIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 +++ H+A V V + + S D + Sbjct: 257 ISTAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFD-STDNTVGYSVSQDHTIKTW 315 Query: 129 EFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN 188 + + A I + S++ +I + N G + + + Sbjct: 316 DL----------VTARCIDTRTTSYSLLSIAQLSTLN------LLACGSSARHITLHDPR 359 Query: 189 SDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLL 248 A + V + L GH ++V + P L S S D T +W D T+ Sbjct: 360 VGASSKVTQQQLIGHKNFVSSLDTCPENEY--ILCSGSHDGTVKVW--DVRSTSPMYTIT 415 Query: 249 KE-----EKFPDVLWRASWSLSGNVLALSGGDNKVTL 280 +E + D ++ W+ ++ +G D K+ + Sbjct: 416 REDKSVQKGVNDKVFAVKWAEKVGII-SAGQDKKIQI 451 Score = 86.0 bits (211), Expect = 2e-17, Method: Composition-based stats. Identities = 54/338 (15%), Positives = 93/338 (27%), Gaps = 100/338 (29%) Query: 9 NELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGT 68 + + + K + + S D ++ +++ G K +GH GP+ V + T Sbjct: 103 EDWVSSLDVGDGSKHIISGSYDGIVRTWDLSGNVQKQY---SGHSGPIRAVKYI---SNT 156 Query: 69 ILASCSYDGKVLIWKEENGRWSQ---------------------IAVHAVHSASVNSVQW 107 L S D + +WK +N +A+ H A V S+ Sbjct: 157 RLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDV 216 Query: 108 APHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGT 167 + + +L AS D + T ++ N S A + +GT Sbjct: 217 SDN---SRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGT 273 Query: 168 KESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQ 227 R ++ LE H+ V V + T Y SVSQ Sbjct: 274 IRRRAPLS-----------------------LLESHTAPVEQVIFDSTDNTVGY--SVSQ 308 Query: 228 DRTCIIWTQDNEQG-------------------------------------------PWK 244 D T W + + Sbjct: 309 DHTIKTWDLVTARCIDTRTTSYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQ 368 Query: 245 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 + L+ + F L + +L D V +W Sbjct: 369 QQLIGHKNFVSSLDTCPENEY--ILCSGSHDGTVKVWD 404 Score = 74.5 bits (181), Expect = 5e-14, Method: Composition-based stats. Identities = 42/275 (15%), Positives = 80/275 (29%), Gaps = 57/275 (20%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIF--------------EVEGETHKL-- 45 + I H + + R+ + S D +I + ++ +K+ Sbjct: 201 LAILEGHKAPVVSIDVSDNS-RILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKIST 259 Query: 46 --------------------IDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEE 85 + L H PV +V + T+ S S D + W Sbjct: 260 AARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDS-TDNTVGYSVSQDHTIKTWDLV 318 Query: 86 NGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTS--PIIIDA 143 R + S+ + LL SS +++ + + ++ + Sbjct: 319 TARCIDTRTTSYSLLSIAQLS-----TLNLLACGSSARHITLHDPRVGASSKVTQQQLIG 373 Query: 144 HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGH 203 H V+S P +G D VK+W S + Y + + Sbjct: 374 HKNFVSSLDTCPEN------------EYILCSGSHDGTVKVWDVRSTSPMYTITREDKSV 421 Query: 204 SDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDN 238 V D ++ + + S QD+ I DN Sbjct: 422 QKGVNDKVFAVKWAEKVGIISAGQDKKIQINKGDN 456 Score = 56.4 bits (134), Expect = 1e-08, Method: Composition-based stats. Identities = 26/146 (17%), Positives = 47/146 (32%), Gaps = 28/146 (19%) Query: 154 APATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWS 213 + + + + S+ ++G D +V+ W + + Q GHS +R V + Sbjct: 99 SFSNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLSGNVQKQYS-----GHSGPIRAVKYI 153 Query: 214 PTVLLRSYLASVSQDRTCIIWTQDNEQGPWK------------------KTLLKEEKFPD 255 + L S DRT +W N+ KTL E Sbjct: 154 SN----TRLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKA 209 Query: 256 VLWRASWSLSGNVLALSGGDNKVTLW 281 + S + + + DN + W Sbjct: 210 PVVSIDVS-DNSRILSASYDNSIGFW 234 >6F1U-h nrPDB Length = 612 Score = 93.7 bits (231), Expect = 8e-20, Method: Composition-based stats. Identities = 54/275 (19%), Positives = 96/275 (34%), Gaps = 24/275 (8%) Query: 15 AVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLT----GHEGPVWRVDWAHPKFGTIL 70 A + + I +++ + H PV+ V+ + L Sbjct: 315 AKFHPN--LVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNL 372 Query: 71 ASCSYDGKVLIWKEENGRWSQIAVHAVH--SASVNSVQWA-PHEYGPLLLVASSDGKVSV 127 S S DGK+ W + Q ++ VH S +V + P +V S +G V Sbjct: 373 ISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYT 432 Query: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 + + + H + A D H FVT D VK+W Sbjct: 433 ACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSH-------LFVTSSFDWTVKLWST 485 Query: 188 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTL 247 ++ Y + E ++ +V DV WSPT + A V +W +N+ ++ Sbjct: 486 KNNKPLY----SFEDNAGYVYDVMWSPTHP--ALFACVDGMGRLDLWNLNNDTEVPTASI 539 Query: 248 LKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 E L R W+ SG +A+ + ++ ++ Sbjct: 540 SVEGN--PALNRVRWTHSGREIAVGDSEGQIVIYD 572 >6CHG-A nrPDB Length = 312 Score = 91.4 bits (225), Expect = 4e-19, Method: Composition-based stats. Identities = 52/288 (18%), Positives = 107/288 (37%), Gaps = 29/288 (10%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 M+ + H E I+ K +A+ S D T+ E+ + I L GH PV + Sbjct: 46 MMKLTTTHKECINCLCWSPDSKCIASGSEDFTV---EITHIIYGRIRRLMGHTAPV--IS 100 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 + G IL S S D + W +G + HS +V S+ P +L S Sbjct: 101 ICYNNKGNILCSSSMDESIKEWHVLSGTALKTMS--AHSDAVVSIDI-PKFDSSILSSGS 157 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 DG + + + + + D I + ++ + + DN Sbjct: 158 YDGLIRIFDTESGHCLKTLTYDKDWIAEDGVV-------PISTVKFSRNGKFLLVKSLDN 210 Query: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLL------RSYLASVSQDRTCIIW 234 +VK+W+Y V+ + L H + + ++ + L + S + + +W Sbjct: 211 VVKLWEYTRGT---VVRTFLWPHQETKAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVW 267 Query: 235 TQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 ++ + + ++ + ++ S S S + +A + + L++ Sbjct: 268 NVYSKN--LVQKIDEKHRNSPLI---SISASYDKVATLSLNGECNLFR 310 >4PSX-B nrPDB Length = 401 Score = 91.4 bits (225), Expect = 4e-19, Method: Composition-based stats. Identities = 51/290 (17%), Positives = 101/290 (34%), Gaps = 40/290 (13%) Query: 8 HNELIHDAVLDYYG-KRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H E I A +AT + T ++ + L TL H+ + + ++ Sbjct: 117 HEEEITRARYMPQDPNIVATINGQGTTFLY---SRSEGLQSTLKFHKDNGYALSFSTLVK 173 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHA---VHSASVNSVQWAPHEYGPLLLVASSDG 123 G +L S S D V +W+ +G V +HS +N +W + L S D Sbjct: 174 GRLL-SGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWH-NFNKDLFGTVSEDS 231 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 + + + + N TT + N+ +++ + S G D+ V Sbjct: 232 LLKINDVRANNTTIDTVK--CPQPFNTLAFSHHS------------SNLLAAAGMDSYVY 277 Query: 184 IWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ------- 236 ++ + + GH D V ++ +S V + S D ++W Sbjct: 278 LYDLRN---MKEPLHHMSGHEDAVNNLEFSTHVDG--VVVSSGSDNRLMMWDLKQIGAEQ 332 Query: 237 ---DNEQGPWKKTLLKEEKFPDVLWRASWSLSGN-VLALSGGDNKVTLWK 282 D E G + ++ + + ++A + +N + +WK Sbjct: 333 TPDDAEDGVPELIMV-HAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 Score = 74.8 bits (182), Expect = 4e-14, Method: Composition-based stats. Identities = 48/251 (19%), Positives = 84/251 (33%), Gaps = 35/251 (13%) Query: 1 MVVIANAHNELIHDAVLDYYGK-RLATCSSDKTIKIFEV--EGETHKLIDTLTG-HEGPV 56 + H + + K RL + S D T+ ++EV G+ K + T H + Sbjct: 152 LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDII 211 Query: 57 WRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLL 116 W H + + S D + I + V N++ ++ H LL Sbjct: 212 NDNKW-HNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCP--QPFNTLAFS-HHSSNLL 267 Query: 117 LVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTG 176 A D V + + + N + H VN+ ++ V+ Sbjct: 268 AAAGMDSYVYLYDLR-NMKEPLHHMSGHEDAVNNLEFSTHV------------DGVVVSS 314 Query: 177 GADNLVKIWKY--------NSDAQTYV--LESTLEGHSDWVRDVAWSPTVLLRSYL-ASV 225 G+DN + +W DA+ V L GH V D +P + +L AS Sbjct: 315 GSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQI---PWLVASA 371 Query: 226 SQDRTCIIWTQ 236 ++ +W Sbjct: 372 EEENILQVWKC 382 Score = 63.3 bits (152), Expect = 1e-10, Method: Composition-based stats. Identities = 45/240 (18%), Positives = 81/240 (33%), Gaps = 37/240 (15%) Query: 50 TGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAP 109 HE + R + P+ I+A+ + G ++ G S H + ++ ++ Sbjct: 115 YEHEEEITRARY-MPQDPNIVATINGQGTTFLYSRSEGLQS---TLKFHKDNGYALSFST 170 Query: 110 HEYGPLLLVASSDGKVSVVEFKENGTTSPII---IDAHAIGVNSASWAPATIEEDGEHNG 166 G LL S D V++ E G + + D H+ +N W Sbjct: 171 LVKGRLL-SGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWH------------ 217 Query: 167 TKESRKFVTGGADNLVKIWKYNSD---AQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLA 223 F T D+L+KI ++ T +A+S + LA Sbjct: 218 NFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPF-------NTLAFSHH--SSNLLA 268 Query: 224 SVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLS-GNVLALSGGDNKVTLWK 282 + D ++ N + P L D + +S V+ SG DN++ +W Sbjct: 269 AAGMDSYVYLYDLRNMKEP----LHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWD 324 Score = 48.3 bits (113), Expect = 4e-06, Method: Composition-based stats. Identities = 24/151 (15%), Positives = 51/151 (33%), Gaps = 8/151 (5%) Query: 131 KENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSD 190 +E G + A + + E ++ T ++ + Sbjct: 92 EEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTTFLYSRSEG 151 Query: 191 AQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKE 250 Q STL+ H D +++S L++ L S S D T +W + P K Sbjct: 152 LQ-----STLKFHKDNGYALSFS--TLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWN 204 Query: 251 EKFPDVLWRASW-SLSGNVLALSGGDNKVTL 280 + D++ W + + ++ D+ + + Sbjct: 205 DLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 >5K0Y-T nrPDB Length = 329 Score = 89.1 bits (219), Expect = 2e-18, Method: Composition-based stats. Identities = 56/327 (17%), Positives = 105/327 (32%), Gaps = 68/327 (20%) Query: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 ++ H I + G L T + D + ++ + + T GH G VW VD Sbjct: 4 ILLQGHERSITQIKYNREGDLLFTVAKDPIVNVW--YSVNGERLGTYMGHTGAVWCVDA- 60 Query: 63 HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD 122 + + S D +W E G+ Q+A+ +SA V + + ++G +++ S+D Sbjct: 61 -DWDTKHVLTGSADNSCRLWDCETGK--QLALLKTNSA-VRTCGF---DFGGNIIMFSTD 113 Query: 123 GK------VSVVEFKENGTTSP----IIIDAHAIGVNSASWAPATIEEDGEHNG------ 166 + VS + ++ + I + + SA W P H Sbjct: 114 KQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQY 173 Query: 167 -----------------------TKESRKFVTGGADNLVKIWK--YNSDAQTYVLESTLE 201 ++E FVT DN K++ +T+ E E Sbjct: 174 SAKSGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRE 233 Query: 202 GHSDWVRDVAWSPTVLLRSYLASVSQ---DRT---CIIWTQDNEQG--PWKKTLLKEEKF 253 A SP + Q D T I + +++ + + Sbjct: 234 -------LAALSPN--YEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGH 284 Query: 254 PDVLWRASWSLSGNVLALSGGDNKVTL 280 + ++ G + G D V + Sbjct: 285 FGPINSVAFHPDGKSYSSGGEDGYVRI 311 Score = 52.5 bits (124), Expect = 2e-07, Method: Composition-based stats. Identities = 28/138 (20%), Positives = 42/138 (30%), Gaps = 17/138 (12%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 H+ I+D L T S D T K+F+ T + T P + P Sbjct: 184 VKEHSRQINDIQLSREMTMFVTASKDNTAKLFD--STTLEHQKTFR--TEPPRELAALSP 239 Query: 65 KFGTILASCS---YDGK---VLIWKEENGRW-----SQIAVHAVHSASVNSVQWAPHEYG 113 + ++ D I K E + + H +NSV + P G Sbjct: 240 NYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPD--G 297 Query: 114 PLLLVASSDGKVSVVEFK 131 DG V + F Sbjct: 298 KSYSSGGEDGYVRIHYFD 315 Score = 49.0 bits (115), Expect = 2e-06, Method: Composition-based stats. Identities = 14/83 (16%), Positives = 25/83 (30%), Gaps = 8/83 (9%) Query: 200 LEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWR 259 L+GH + + + L +V++D +W N + L +W Sbjct: 6 LQGHERSITQIKY---NREGDLLFTVAKDPIVNVWYSVNGE-----RLGTYMGHTGAVWC 57 Query: 260 ASWSLSGNVLALSGGDNKVTLWK 282 + DN LW Sbjct: 58 VDADWDTKHVLTGSADNSCRLWD 80 >4AEZ-A nrPDB Length = 401 Score = 89.1 bits (219), Expect = 2e-18, Method: Composition-based stats. Identities = 48/273 (17%), Positives = 96/273 (35%), Gaps = 32/273 (11%) Query: 11 LIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTIL 70 + + G L+ + + I++VE +T + T+ GH+ V + W +L Sbjct: 136 YVASVKWSHDGSFLSVGLGNGLVDIYDVESQTK--LRTMAGHQARVGCLSWNR----HVL 189 Query: 71 ASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEF 130 +S S G + QI HS+ V + W G L +D V + + Sbjct: 190 SSGSRSGAIHHHDVRIAN-HQIGTLQGHSSEVCGLAWRSD--GLQLASGGNDNVVQIWDA 246 Query: 131 KENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSD 190 + + H V + +W P GT D + W + Sbjct: 247 R--SSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGT----------MDKQIHFWNAATG 294 Query: 191 AQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQ-DRTCIIWTQDNEQGPWKKTLLK 249 A+ +++ + V + WSP + +++ D IW+ + G K+ + Sbjct: 295 ARVNTVDAGSQ-----VTSLIWSPH--SKEIMSTHGFPDNNLSIWSY-SSSGLTKQ--VD 344 Query: 250 EEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 + ++ S G +L+ + D + W+ Sbjct: 345 IPAHDTRVLYSALSPDGRILSTAASDENLKFWR 377 Score = 82.2 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 37/191 (19%), Positives = 67/191 (35%), Gaps = 21/191 (10%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 + H+ + G +LA+ +D ++I++ K T H V V W Sbjct: 210 IGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTN--HNAAVKAVAW 267 Query: 62 AHPKFGTILASCS--YDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA 119 P +LA+ D ++ W G + V S+ W+PH + Sbjct: 268 C-PWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAG---SQVTSLIWSPHSKEIMSTHG 323 Query: 120 SSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGAD 179 D +S+ + +G T + I AH V ++ +P + R T +D Sbjct: 324 FPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSP-------------DGRILSTAASD 370 Query: 180 NLVKIWKYNSD 190 +K W+ Sbjct: 371 ENLKFWRVYDG 381 Score = 44.8 bits (104), Expect = 4e-05, Method: Composition-based stats. Identities = 18/94 (19%), Positives = 30/94 (31%), Gaps = 9/94 (9%) Query: 190 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLK 249 D ++ T+ GH V ++W+ VL + I + Sbjct: 162 DVESQTKLRTMAGHQARVGCLSWNRHVLSSGSRSGAIHHHDVRI---------ANHQIGT 212 Query: 250 EEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKE 283 + + +W G LA G DN V +W Sbjct: 213 LQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDA 246 Score = 29.8 bits (65), Expect = 1.5, Method: Composition-based stats. Identities = 11/39 (28%), Positives = 20/39 (51%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETH 43 AH+ + + L G+ L+T +SD+ +K + V H Sbjct: 345 IPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDH 383 Score = 27.9 bits (60), Expect = 5.9, Method: Composition-based stats. Identities = 13/67 (19%), Positives = 27/67 (40%), Gaps = 4/67 (5%) Query: 222 LASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 + +V+ +R +W D+ L E + WS G+ L++ G+ V ++ Sbjct: 106 VVAVALERNVYVWNADSGSVSA----LAETDESTYVASVKWSHDGSFLSVGLGNGLVDIY 161 Query: 282 KENLEGK 288 + K Sbjct: 162 DVESQTK 168 >4OWR-A nrPDB Length = 339 Score = 88.7 bits (218), Expect = 3e-18, Method: Composition-based stats. Identities = 50/318 (15%), Positives = 97/318 (30%), Gaps = 59/318 (18%) Query: 2 VVIANAHNELIHDAVLDYY---GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWR 58 + + ++ ++ I G L S ++ +EV+ + H GPV Sbjct: 3 IEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLD 62 Query: 59 VDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 118 V W+ G+ + + S D +W + + QIA H A V ++ W ++ Sbjct: 63 VCWS--DDGSKVFTASCDKTAKMWDLSSNQAIQIAQ---HDAPVKTIHWIKAPNYSCVMT 117 Query: 119 ASSDGKVSVVEFKEN---------------GTTSPIIIDAH---AIGVNSASWAPATIEE 160 S D + + + + P+ + A + V P+ Sbjct: 118 GSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRR 177 Query: 161 DGE------------HNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDW-- 206 + + F G + V I Y + T + H Sbjct: 178 IESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAI-HYINPPNPAKDNFTFKCHRSNGT 236 Query: 207 ----------VRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDV 256 V +A+ P + LA+V D W +D L E+ Sbjct: 237 NTSAPQDIYAVNGIAFHP---VHGTLATVGSDGRFSFWDKDART-----KLKTSEQLDQP 288 Query: 257 LWRASWSLSGNVLALSGG 274 + ++ +GN+ A + Sbjct: 289 ISACCFNHNGNIFAYASS 306 Score = 52.9 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 13/81 (16%), Positives = 29/81 (35%), Gaps = 3/81 (3%) Query: 204 SDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWS 263 D + +++SP L ++L + S W Q + ++ + WS Sbjct: 10 DDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEV---QDSGQTIPKAQQMHTGPVLDVCWS 66 Query: 264 LSGNVLALSGGDNKVTLWKEN 284 G+ + + D +W + Sbjct: 67 DDGSKVFTASCDKTAKMWDLS 87 >5A31-R nrPDB Length = 386 Score = 88.7 bits (218), Expect = 3e-18, Method: Composition-based stats. Identities = 45/237 (18%), Positives = 83/237 (35%), Gaps = 29/237 (12%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 + + H + + + L + S D I +V +T+ H V + Sbjct: 165 CIRTLSGHIDRVACLS--WNNHVLTSGSRDHRILHRDVRMPD-PFFETIESHTQEVCGLK 221 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLL-LVA 119 W LAS D V +++ + S I H A+V ++ W+PH+ G L Sbjct: 222 WN--VADNKLASGGNDNVVHVYEGTSK--SPILTFDEHKAAVKAMAWSPHKRGVLATGGG 277 Query: 120 SSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGAD 179 ++D ++ + + S I + + W+ T E H G + Sbjct: 278 TADRRLKIWNVNTSIKMSDI---DSGSQICNMVWSKNTNELVTSH-----------GYSK 323 Query: 180 NLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ 236 + +W D + + L+GHS V + S + + S + D T W Sbjct: 324 YNLTLW----DCNSMDPIAILKGHSFRVLHLTLSND---GTTVVSGAGDETLRYWKL 373 Score = 69.8 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 54/304 (17%), Positives = 92/304 (30%), Gaps = 67/304 (22%) Query: 17 LDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYD 76 +D+ + + K+I + + T ++ L E + W G+ LA + Sbjct: 98 IDWSSTDVLAVALGKSIFL--TDNNTGDVVH-LCDTENEYTSLSWIG--AGSHLAVGQAN 152 Query: 77 GKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTT 136 G V I+ + I + H V + W H +L S D ++ + + Sbjct: 153 GLVEIYDVMKRKC--IRTLSGHIDRVACLSWNNH----VLTSGSRDHRILHRDVRMPDPF 206 Query: 137 SPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVL 196 I ++H V W K +GG DN+V +++ + Sbjct: 207 FETI-ESHTQEVCGLKWN-------------VADNKLASGGNDNVVHVYE----GTSKSP 248 Query: 197 ESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT-------QDNEQGPWKK---- 245 T + H V+ +AWSP + DR IW D + G Sbjct: 249 ILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVW 308 Query: 246 --------TLLKEEKFPDVLWRAS-------------------WSLSGNVLALSGGDNKV 278 T K+ LW + S G + GD + Sbjct: 309 SKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETL 368 Query: 279 TLWK 282 WK Sbjct: 369 RYWK 372 >4U1E-I nrPDB Length = 347 Score = 88.3 bits (217), Expect = 3e-18, Method: Composition-based stats. Identities = 47/331 (14%), Positives = 104/331 (31%), Gaps = 72/331 (21%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHP 64 H + + G L +CS D + ++ + + TL GH G +W +D Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVW--YSLNGERLGTLDGHTGTIWSIDV--D 61 Query: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD-- 122 F + S D + +W NG+ V V V+++P G L + Sbjct: 62 CFTKYCVTGSADYSIKLWDVSNGQCVATWKSPV---PVKRVEFSP--CGNYFLAILDNVM 116 Query: 123 ---GKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGAD 179 G +++ E + + T + + ++ ++ + + + + G D Sbjct: 117 KNPGSINIYEIERDSATHELTKVS-EEPIHKIITH-EGLDAATVAGWSTKGKYIIAGHKD 174 Query: 180 NLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDR--------TC 231 + + +++ Y +++ H + D+ +SP + +Y + S+D T Sbjct: 175 GKISKYDVSNN---YEYVDSIDLHEKSISDMQFSPDL---TYFITSSRDTNSFLVDVSTL 228 Query: 232 IIWTQDNEQGPW------------------------------------------KKTLLK 249 + + P ++ + + Sbjct: 229 QVLKKYETDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGR 288 Query: 250 EEKFPDVLWRASWSLSGNVLALSGGDNKVTL 280 + L + S G A G D + L Sbjct: 289 VQGHFGPLNTVAISPQGTSYASGGEDGFIRL 319 Score = 54.8 bits (130), Expect = 4e-08, Method: Composition-based stats. Identities = 39/219 (17%), Positives = 74/219 (33%), Gaps = 36/219 (16%) Query: 91 QIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNS 150 + H + V++ ++ G LL S D SV +D H + S Sbjct: 2 KAIKLTGHERPLTQVKY--NKEGDLLFSCSKDSSASVWYSLNGERLG--TLDGHTGTIWS 57 Query: 151 ASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDV 210 T VTG AD +K+W D +T + V+ V Sbjct: 58 IDVDCFTKYC-------------VTGSADYSIKLW----DVSNGQCVATWKS-PVPVKRV 99 Query: 211 AWSPTVLLRSYLASVSQ----DRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWR------- 259 +SP +LA + + I+ + + + T + EE ++ Sbjct: 100 EFSP--CGNYFLAILDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAAT 157 Query: 260 -ASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 A WS G + D K++ + + ++ + ++H+ Sbjct: 158 VAGWSTKGKYIIAGHKDGKISKYDVSNNYEYVDSIDLHE 196 >4BH6-A nrPDB Length = 308 Score = 86.0 bits (211), Expect = 2e-17, Method: Composition-based stats. Identities = 45/237 (18%), Positives = 83/237 (35%), Gaps = 29/237 (12%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 + + H + + + L + S D I +V +T+ H V + Sbjct: 96 CIRTLSGHIDRVACLS--WNNHVLTSGSRDHRILHRDVRMPD-PFFETIESHTQEVCGLK 152 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLL-LVA 119 W LAS D V +++ + S I H A+V ++ W+PH+ G L Sbjct: 153 WN--VADNKLASGGNDNVVHVYEGTSK--SPILTFDEHKAAVKAMAWSPHKRGVLATGGG 208 Query: 120 SSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGAD 179 ++D ++ + + S I + + W+ T E H G + Sbjct: 209 TADRRLKIWNVNTSIKMSDI---DSGSQICNMVWSKNTNELVTSH-----------GYSK 254 Query: 180 NLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ 236 + +W D + + L+GHS V + S + + S + D T W Sbjct: 255 YNLTLW----DCNSMDPIAILKGHSFRVLHLTLSND---GTTVVSGAGDETLRYWKL 304 Score = 67.9 bits (164), Expect = 6e-12, Method: Composition-based stats. Identities = 53/273 (19%), Positives = 93/273 (34%), Gaps = 37/273 (13%) Query: 17 LDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYD 76 +D+ + + K+I + + T ++ L E + W G+ LA + Sbjct: 29 IDWSSTDVLAVALGKSIFL--TDNNTGDVVH-LCDTENEYTSLSWI--GAGSHLAVGQAN 83 Query: 77 GKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTT 136 G V I+ + I + H V + W H +L S D ++ + + Sbjct: 84 GLVEIYDVMKRKC--IRTLSGHIDRVACLSWNNH----VLTSGSRDHRILHRDVRMPDPF 137 Query: 137 SPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVL 196 I ++H V W K +GG DN+V +++ + Sbjct: 138 FETI-ESHTQEVCGLKWN-------------VADNKLASGGNDNVVHVYE----GTSKSP 179 Query: 197 ESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDV 256 T + H V+ +AWSP + DR IW + + + Sbjct: 180 ILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTS------IKMSDIDSGSQ 233 Query: 257 LWRASWSLSGNVLALSGGDNK--VTLWKENLEG 287 + WS + N L S G +K +TLW N Sbjct: 234 ICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMD 266 >1NR0-A nrPDB Length = 611 Score = 85.6 bits (210), Expect = 2e-17, Method: Composition-based stats. Identities = 49/246 (19%), Positives = 83/246 (33%), Gaps = 27/246 (10%) Query: 38 VEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAV 97 V T I T H+ V + G AS G V IW V Sbjct: 46 VGSLTDTEIYTEHSHQTTVAKTS----PSGYYCASGDVHGNVRIWDTTQTTHILKTTIPV 101 Query: 98 HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPAT 157 S V + W + + F + TS + A +NS + P+ Sbjct: 102 FSGPVKDISW--DSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSR 159 Query: 158 IEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVL 217 + ++G DN V I++ + +ST H+ +V V ++P Sbjct: 160 PF------------RIISGSDDNTVAIFEGPP----FKFKSTFGEHTKFVHSVRYNPD-- 201 Query: 218 LRSYLASVSQDRTCIIWT--QDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGD 275 S AS D T +++ + G ++ LK ++ +WS G +A + D Sbjct: 202 -GSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASAD 260 Query: 276 NKVTLW 281 + +W Sbjct: 261 KTIKIW 266 Score = 77.5 bits (189), Expect = 6e-15, Method: Composition-based stats. Identities = 57/348 (16%), Positives = 99/348 (28%), Gaps = 80/348 (22%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFE----------------------------- 37 AH+ + G ++A+ S+DKTIKI+ Sbjct: 237 AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA 296 Query: 38 ------------VEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEE 85 V E + GH + + + G L S +G + W Sbjct: 297 LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSAD--GKTLFSADAEGHINSWDIS 354 Query: 86 NGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDA-- 143 G +++ VH+ + ++ L S D + VV +G S + Sbjct: 355 TGISNRVFP-DVHATMITGIKTTSKGD---LFTVSWDDHLKVVPAGGSGVDSSKAVANKL 410 Query: 144 ----------------------HAIGVNSASWAPATIEEDGEHNGTKESRKFVT-GGADN 180 H + I + ++FV GG D+ Sbjct: 411 SSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDS 470 Query: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 V ++K + + V E H + VA+S ++L + D++ + Sbjct: 471 KVHVYKLSGAS---VSEVKTIVHPAEITSVAFSNN---GAFLV--ATDQSRKVIPYSVAN 522 Query: 241 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGK 288 + SWS LA DN V +W N Sbjct: 523 NFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 Score = 69.8 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 51/327 (15%), Positives = 89/327 (27%), Gaps = 76/327 (23%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 I H+ A G A+ ++I++ TH L T+ GPV + W Sbjct: 54 IYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS 113 Query: 64 -------------------------------------------PKFGTILASCSYDGKVL 80 P + S S D V Sbjct: 114 ESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVA 173 Query: 81 IWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENG-----T 135 I E + + H+ V+SV++ P G L DG + + + Sbjct: 174 I--FEGPPFKFKSTFGEHTKFVHSVRYNPD--GSLFASTGGDGTIVLYNGVDGTKTGVFE 229 Query: 136 TSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYV 195 + AH+ V +W+P + K + AD +KIW + + Sbjct: 230 DDSLKNVAHSGSVFGLTWSP-------------DGTKIASASADKTIKIWNVAT-LKVEK 275 Query: 196 LESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPD 255 D + W+ + L S+S + + + Sbjct: 276 TIPVGTRIEDQQLGIIWT-----KQALVSISANGFINFVNPELGSIDQVR-----YGHNK 325 Query: 256 VLWRASWSLSGNVLALSGGDNKVTLWK 282 + S S G L + + + W Sbjct: 326 AITALSSSADGKTLFSADAEGHINSWD 352 Score = 60.2 bits (144), Expect = 9e-10, Method: Composition-based stats. Identities = 39/180 (21%), Positives = 62/180 (34%), Gaps = 24/180 (13%) Query: 57 WRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLL 116 V ++ K +A D KV ++K S++ VH A + SV ++ + G L Sbjct: 452 SCVALSNDKQ--FVAVGGQDSKVHVYKLSGASVSEVKTI-VHPAEITSVAFSNN--GAFL 506 Query: 117 LVASSDGKVSVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVT 175 + KV N + H V SW+P ++ + T Sbjct: 507 VATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP-------------DNVRLAT 553 Query: 176 GGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 G DN V +W N + ++ S V V W L + + S QD W Sbjct: 554 GSLDNSVIVWNMNKPSDHPIIIKGAHAMSS-VNSVIW----LNETTIVSAGQDSNIKFWN 608 Score = 57.5 bits (137), Expect = 7e-09, Method: Composition-based stats. Identities = 28/127 (22%), Positives = 42/127 (33%), Gaps = 9/127 (7%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDT--LTGHEGPVWRVDWAHPK 65 H I G L + + + V +L T T H V V W+ Sbjct: 490 HPAEITSVAFSNNGAFLVATDQSRKVIPYSVANN-FELAHTNSWTFHTAKVACVSWSPDN 548 Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHS-ASVNSVQWAPHEYGPLLLVASSDGK 124 LA+ S D V++W I + H+ +SVNSV W ++ A D Sbjct: 549 VR--LATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT---IVSAGQDSN 603 Query: 125 VSVVEFK 131 + Sbjct: 604 IKFWNVP 610 >3ACP-A nrPDB Length = 417 Score = 82.9 bits (203), Expect = 1e-16, Method: Composition-based stats. Identities = 50/306 (16%), Positives = 95/306 (31%), Gaps = 42/306 (13%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 I AH I G+ L + S D +KI+ V+ ++ TL GH V + Sbjct: 131 IDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNP--RTLIGHRATVTDIAII- 187 Query: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 G + S S DG + +W E G + I + V + L +D Sbjct: 188 -DRGRNVLSASLDGTIRLW--ECGTGTTIHTFNRKENPHDGV-------NSIALFVGTDR 237 Query: 124 KVSVVEFKEN-----GTTSPIIIDAHAIGVNSA--SWAPA---------TIEEDGEHNGT 167 ++ + + GT +I H GV + ++ T + Sbjct: 238 QLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSCNSLTVDG 297 Query: 168 KESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQ 227 + G + ++ W S + L + +V ++ + S Sbjct: 298 NNANYIYAGYENGMLAQWDLRSP--ECPVGEFLINEGTPINNVYFA----AGALFVSSGF 351 Query: 228 DRTCI---IWTQDNEQGPWKKT----LLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTL 280 D + I ++E+ + L+ + S S + G +N L Sbjct: 352 DTSIKLDIISDPESERPAIEFETPTFLVSNDDEVSQFCYVSDDESNGEVLEVGKNNFCAL 411 Query: 281 WKENLE 286 + + Sbjct: 412 YNLSNP 417 Score = 49.4 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 22/112 (19%), Positives = 43/112 (38%), Gaps = 12/112 (10%) Query: 171 RKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT 230 R+F+ G + +K+ N + Q + H + + + P+ L S SQD Sbjct: 107 RRFILGTTEGDIKVLDSNFNLQR----EIDQAHVSEITKLKFFPS---GEALISSSQDMQ 159 Query: 231 CIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 IW+ + G +TL+ + + G + + D + LW+ Sbjct: 160 LKIWS--VKDGSNPRTLIGHR---ATVTDIAIIDRGRNVLSASLDGTIRLWE 206 >5A9Q-2 nrPDB Length = 326 Score = 81.8 bits (200), Expect = 3e-16, Method: Composition-based stats. Identities = 42/199 (21%), Positives = 71/199 (35%), Gaps = 27/199 (13%) Query: 99 SASVNSVQWAPHEYGP---LLLVASSD----GKVSVVEFK---ENGTTSPIIIDAHAIGV 148 V+ V++ P E G L+ ++ G + E + E + H + V Sbjct: 16 EDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVRV 75 Query: 149 NSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVR 208 + +W+P T + KF T AD +KI + SD Q LEGH+D++ Sbjct: 76 DGIAWSPET-----RLDSLPPVIKFCTSAAD--MKIRLFTSDLQDKNEYKVLEGHTDFIN 128 Query: 209 DVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNV 268 + + P +ASVS D TC IW + Q W Sbjct: 129 GLVFDPKE--GQEIASVSDDHTCRIWNLEGVQ-------TAHFVLHSPGMSVCWHPEETF 179 Query: 269 -LALSGGDNKVTLWKENLE 286 L ++ + + + + Sbjct: 180 KLMVAEKNGTIRFYDLLAQ 198 Score = 67.5 bits (163), Expect = 6e-12, Method: Composition-based stats. Identities = 52/290 (17%), Positives = 92/290 (31%), Gaps = 54/290 (18%) Query: 8 HNELIHDAVLDYYGK--------RLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRV 59 H + + + T ++D I++F + + L GH + + Sbjct: 71 HGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGL 130 Query: 60 DWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA 119 + PK G +AS S D IW E Q A +HS SV W P E L+VA Sbjct: 131 VFD-PKEGQEIASVSDDHTCRIWNLEG---VQTAHFVLHS-PGMSVCWHPEETFK-LMVA 184 Query: 120 SSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGAD 179 +G + + + + +++ + + SA W + G G D Sbjct: 185 EKNGTIRFYDLLA--QQAILSLESEQVPLMSAHWCLKNTFKVG-----------AVAGND 231 Query: 180 NLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNE 239 W ++ ++ H D WS + + A+ Sbjct: 232 -----WLIWDITRSSYPQNKRPVHMDRACLFRWS--TISENLFATTGY------------ 272 Query: 240 QGPWKKTLLKEE-KFPDVLWRASWSLSGNV-------LALSGGDNKVTLW 281 G P + S ++ + L + GGD+K+ W Sbjct: 273 PGKMASQFQIHHLGHPQPILMGSVAVGSGLSWHRTLPLCVIGGDHKLLFW 322 Score = 55.2 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 29/155 (18%), Positives = 50/155 (32%), Gaps = 17/155 (10%) Query: 4 IANAHNELIHDAVLDY-YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGH---EGPVWRV 59 + H + I+ V D G+ +A+ S D T +I+ +EG T H P V Sbjct: 119 VLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEG-------VQTAHFVLHSPGMSV 171 Query: 60 DWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA 119 W HP+ L +G + + + I + S W + VA Sbjct: 172 CW-HPEETFKLMVAEKNGTIRFYDLLAQQA--ILSLESEQVPLMSAHWCLKNTFKVGAVA 228 Query: 120 SSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWA 154 +D + + + H W+ Sbjct: 229 GND--WLIWDITRSSYPQNKR-PVHMDRACLFRWS 260 >5CXC-A nrPDB Length = 510 Score = 81.8 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 56/339 (16%), Positives = 100/339 (29%), Gaps = 79/339 (23%) Query: 17 LDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLT--GHEGPVWRVDWAHPKFGTILASCS 74 + +R+ + S D ++I+ G + + GH + + LAS Sbjct: 154 VQPGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDR---LASAG 210 Query: 75 YDGKVLIW-----KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVE 129 D V +W G H+ SV+ + + +L AS+DG + Sbjct: 211 MDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDV--DGHSKHILTASADGAIGFWS 268 Query: 130 FKENGTTSP---IIIDAH----AIGVNSAS---------WAPATIEEDGEHNGTKESRKF 173 + P ++ AH +S S W+ T ++ Sbjct: 269 ASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVA 328 Query: 174 VTGGADNLVKIWKYNSD------------------------------------------- 190 + D+ V+ + Sbjct: 329 YSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPR 388 Query: 191 -AQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT--L 247 + TL GH++ V V+ SP+ L S S D TC +W + + K+ L Sbjct: 389 ASSATTSVMTLRGHANKV--VSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSL 446 Query: 248 LKEEKFPDVLWRASWSLSGNVLALSGGDNK---VTLWKE 283 + V+ R SW+ G GD +W + Sbjct: 447 GGVSEPVYVIERESWASKGKKKRPVAGDGCKVFSVVWDK 485 Score = 66.0 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 45/263 (17%), Positives = 82/263 (31%), Gaps = 50/263 (19%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIF----------------------------EV 38 H + +D + K + T S+D I + V Sbjct: 238 GHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSV 297 Query: 39 EGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVH 98 + + H P + P+ T+ S S D V G+ Sbjct: 298 STAQRGPLGLWSIHTAPATAAIFD-PRDRTVAYSASQDHTVRTLDLTTGQVVSTLTL--- 353 Query: 99 SASVNSVQWAPH--EYGPLLLVASSDGKVSVVEFKENG-TTSPIIIDAHAIGVNSASWAP 155 + + S+ PLL +S +++V+ + + TTS + + HA V S S +P Sbjct: 354 THPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSP 413 Query: 156 ATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDV---AW 212 V+G D ++W S E +L G S+ V + +W Sbjct: 414 EN------------EYSLVSGSHDGTCRVWDLRSVRPATKEEGSLGGVSEPVYVIERESW 461 Query: 213 SPTVLLRSYLASVSQDRTCIIWT 235 + + +A ++W Sbjct: 462 ASKGKKKRPVAGDGCKVFSVVWD 484 Score = 60.2 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 23/132 (17%), Positives = 43/132 (32%), Gaps = 8/132 (6%) Query: 167 TKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVS 226 + ++ D L++IW + + GH+ ++ + L LAS Sbjct: 155 QPGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKF----LTSDRLASAG 210 Query: 227 QDRTCIIWTQ---DNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKE 283 DRT +W D+ G K TL + + + + D + W Sbjct: 211 MDRTVRVWKYTESDHFTGELKPTL-ELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSA 269 Query: 284 NLEGKWEPAGEV 295 + EP + Sbjct: 270 SKASAPEPDASL 281 >5WYJ-BE nrPDB Length = 939 Score = 81.4 bits (199), Expect = 4e-16, Method: Composition-based stats. Identities = 50/350 (14%), Positives = 99/350 (28%), Gaps = 86/350 (24%) Query: 7 AHNELIHDAVL-DYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEG----------- 54 H++ D + + S D+++ F + + + H+ Sbjct: 348 GHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTI 407 Query: 55 -----PVWRVDWAHPKFGT--ILASCSYD-GKVLIWKEENGRWSQIAVHAVHSASVNSVQ 106 + + + + G + + D W N R + V SV Sbjct: 408 KSKFPEIVALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVA 467 Query: 107 WAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNG 166 + + G + SS+G +++ + + H V S Sbjct: 468 MS--QCGNFGFIGSSNGSITIYNMQSGILRKKYKL--HKRAVTGISLD------------ 511 Query: 167 TKESRKFVTGGADNLVKIWKYNS------------------------------------- 189 +RK V+ G D +V + +N Sbjct: 512 -GMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLDAPITAMVYHRSSDLFALALDDLSIVVI 570 Query: 190 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLK 249 DA T + L GHS+ + +SP ++ S S D T W + Sbjct: 571 DAVTQRVVRQLWGHSNRITAFDFSPE---GRWIVSASLDSTIRTWDL------PTGGCID 621 Query: 250 EEKFPDVLWRASWSLSGNVLAL--SGGDNKVTLWKENLEGKWEPAGEVHQ 297 +V +S +G++LA G+ +W + K + + Sbjct: 622 GIIVDNVATNVKFSPNGDLLATTHVTGNGIC-IWTNRAQFKTVSTRTIDE 670 >6E29-D nrPDB Length = 345 Score = 81.0 bits (198), Expect = 5e-16, Method: Composition-based stats. Identities = 60/295 (20%), Positives = 109/295 (36%), Gaps = 31/295 (10%) Query: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 I + H+ + G LA+ D T+ I+++ ET + L GH + + W+ Sbjct: 22 TIRSGHS---TCVRFNRKGDFLASGRVDGTVVIWDL--ETMGVARKLRGHSKNITSLSWS 76 Query: 63 HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD 122 + G L S KV++W ++G+ + A V + P + D Sbjct: 77 --RCGRYLLSACQGWKVILWDLQDGKRYREVRF---RAPVYGAELHPWNHHQFAAALFED 131 Query: 123 GKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFV-TGGADN- 180 +V+ E ++ S PA E+ + + + V T D+ Sbjct: 132 Q-PMLVDITEPVEVRYVLPSVPKR--TSTETDPALREKQAKEDAKHMTTAIVYTASGDHL 188 Query: 181 ---LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQD 237 K DA+T + + + S + + + + L +QDR + Sbjct: 189 LAGTTKGRLNIIDARTREIIYSEKIASGIITTLRLTES---GRELLVNAQDRIIRTFIVP 245 Query: 238 N----EQGPWKKTLLKEEKFPDVLWRASW-----SLSGNVLALSGGDN-KVTLWK 282 N + P L E KF DV+ R SW S +G +A S +N ++ +W+ Sbjct: 246 NLSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWE 300 Score = 32.1 bits (71), Expect = 0.29, Method: Composition-based stats. Identities = 7/34 (20%), Positives = 11/34 (32%) Query: 254 PDVLWRASWSLSGNVLALSGGDNKVTLWKENLEG 287 ++ G+ LA D V +W G Sbjct: 25 SGHSTCVRFNRKGDFLASGRVDGTVVIWDLETMG 58 >5N4A-A nrPDB Length = 771 Score = 80.6 bits (197), Expect = 7e-16, Method: Composition-based stats. Identities = 60/276 (21%), Positives = 94/276 (34%), Gaps = 42/276 (15%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTG-----HEGPVWRV 59 AN H+EL + + + TCS D+TI + + GE + + TL H PV Sbjct: 10 ANVHSELTAAVGWNVWNELF-TCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSS- 67 Query: 60 DWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA 119 + A DG V I GR + H + S++W+ G L A Sbjct: 68 KKTQAGGTDVFAVACTDGSVKI-LSRTGRVEKS--IEGHKGACISLRWS--YDGTALATA 122 Query: 120 SSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGAD 179 DG V + NG + A V S WA + D T + + ++ Sbjct: 123 GEDGSVKIW--SRNGMLRSTLAQA-DSPVYSIVWA---YDCDQLCYCTGSNVVIKSLSSN 176 Query: 180 NLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNE 239 WK H V V WSP + + + +D +W Sbjct: 177 AKQNAWK---------------AHDGVVLKVDWSP---INHLIITGGEDCKYKVWDSFGR 218 Query: 240 QGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGD 275 L + F + +W+ SG + A+ G + Sbjct: 219 ------LLFQSGLFDYPVTSVAWAPSGELFAVGGFN 248 Score = 76.8 bits (187), Expect = 9e-15, Method: Composition-based stats. Identities = 46/238 (19%), Positives = 72/238 (30%), Gaps = 43/238 (18%) Query: 52 HEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAP-- 109 H V W L +CS D + W +++ A + W P Sbjct: 13 HSELTAAVGW---NVWNELFTCSDDQTIHKWNMLGEPEQKVSTL---DAYFTDMHWYPVS 66 Query: 110 -----HEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEH 164 + VA +DG V + G I + H S W+ Sbjct: 67 SKKTQAGGTDVFAVACTDGSVKI--LSRTGRVEKSI-EGHKGACISLRWS---------- 113 Query: 165 NGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLAS 224 + T G D VKIW + +L STL V + W+ Y + Sbjct: 114 ---YDGTALATAGEDGSVKIWS-----RNGMLRSTLAQADSPVYSIVWAYDCDQLCY-CT 164 Query: 225 VSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 S + + +Q WK V+ + WS +++ G D K +W Sbjct: 165 GSN-VVIKSLSSNAKQNAWKA-------HDGVVLKVDWSPINHLIITGGEDCKYKVWD 214 Score = 53.7 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 24/119 (20%), Positives = 36/119 (30%), Gaps = 15/119 (12%) Query: 171 RKFVTGGADNLVKIWKYNSDAQTYVLESTLEG-----HSDWVRDVAWSPTVLLRSYLASV 225 + T D + W + + STL+ H V A Sbjct: 26 NELFTCSDDQTIHKWNMLGEPE--QKVSTLDAYFTDMHWYPVSS--KKTQAGGTDVFAVA 81 Query: 226 SQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 D + I + G +K++ E WS G LA +G D V +W N Sbjct: 82 CTDGSVKIL---SRTGRVEKSI---EGHKGACISLRWSYDGTALATAGEDGSVKIWSRN 134 Score = 46.3 bits (108), Expect = 1e-05, Method: Composition-based stats. Identities = 17/105 (16%), Positives = 35/105 (33%), Gaps = 8/105 (7%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 AH+ ++ + T D K+++ G + PV V WA Sbjct: 183 KAHDGVVLKVDWSPINHLIITGGEDCKYKVWDSFGRLLFQSGLF---DYPVTSVAWAP-- 237 Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPH 110 G + A + + + W+ +H + S+ ++ W Sbjct: 238 SGELFAVGGF-NTLQLCDRMG--WAYSKIHLNDTGSIMTLSWTAD 279 >5OQL-X nrPDB Length = 630 Score = 80.6 bits (197), Expect = 8e-16, Method: Composition-based stats. Identities = 43/266 (16%), Positives = 79/266 (29%), Gaps = 35/266 (13%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 H + GK + T +DK + ++ K I T H V + + + Sbjct: 243 QGHLKAPLVVKASQDGKFVVTGGADKRLVVYN--AADLKPIKAFTQHRDAVTGLAFR--R 298 Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 L SCS D V +W + + + H + + E + V + D Sbjct: 299 GTNQLYSCSKDRTVKVWSLD--ELAYVETLFGHQDEILDIDALGQE--RCVSVGARDRTA 354 Query: 126 SVVEFKENGT-TSPIIIDAHAIGVNSASWAPATIEEDGEHNGT------KESRKFVTGGA 178 + E + + P H G+ + FVTG Sbjct: 355 RYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDDMFVTGSD 414 Query: 179 DNLVKIWKYNSDAQTYVLES--------TLEGHS-DWVRDVAWSP-----------TVLL 218 + + +W +V+ LE +S D + D + P T+ Sbjct: 415 NGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTLPY 474 Query: 219 RSYLASVSQDRTCIIWTQDNEQGPWK 244 + S S D +W ++ + Sbjct: 475 SDLIFSGSWDGCIRVWRLSEDKRKLE 500 Score = 71.8 bits (174), Expect = 3e-13, Method: Composition-based stats. Identities = 32/223 (14%), Positives = 73/223 (32%), Gaps = 34/223 (15%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 H + + +L +CS D+T+K++ + + ++TL GH+ + +D + Sbjct: 287 HRDAVTGLAFRRGTNQLYSCSKDRTVKVWSL--DELAYVETLFGHQDEILDIDALGQE-- 342 Query: 68 TILASCSYDGKVLIWKE--------ENGRWSQIAVHAVHSASVNSVQWAPHEYG------ 113 ++ + D WK G + H + G Sbjct: 343 RCVSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVA 402 Query: 114 ----PLLLVASSDGKVSVVEF----------KENGTTSPIIIDAHAIG-VNSASWAPATI 158 + + S +G +++ + +G PI ++ ++ + S PA Sbjct: 403 MIDDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQ 462 Query: 159 E-EDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTL 200 S +G D +++W+ + D + L Sbjct: 463 PRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDKRKLEAVGIL 505 Score = 55.2 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 40/233 (17%), Positives = 72/233 (30%), Gaps = 47/233 (20%) Query: 53 EGPVWRVDWAHPKFGTILASCSYDGKVLIWKEEN---GRWSQIAVHAVHSASVNSVQWAP 109 G V V P + + DG + WK ++ +W Q Sbjct: 170 SGTVTSVAVCPP----YAYTTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKPPAPP----- 220 Query: 110 HEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKE 169 + + A +D + H AP ++ + Sbjct: 221 KKRPERICFAKAD----------ARKANDKTYQGHLK-------APLVVKASQ------D 257 Query: 170 SRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDR 229 + VTGGAD + ++ +A H D V +A+ + L S S+DR Sbjct: 258 GKFVVTGGADKRLVVY----NAADLKPIKAFTQHRDAVTGLAFR---RGTNQLYSCSKDR 310 Query: 230 TCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 T +W+ D + + +TL + D + +++ D WK Sbjct: 311 TVKVWSLD--ELAYVETLFGHQ---DEILDIDALGQERCVSVGARDRTARYWK 358 Score = 41.0 bits (94), Expect = 6e-04, Method: Composition-based stats. Identities = 26/179 (14%), Positives = 52/179 (29%), Gaps = 47/179 (26%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLI-------------DT 48 V H + I D + ++ + D+T + ++V E+ + Sbjct: 323 VETLFGHQDEILDIDALGQERCVSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHK 382 Query: 49 LT--------GHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHA-VHS 99 L HEG + RV + + S +G + +W + + + A Sbjct: 383 LPPGMDPASAAHEGSMDRVAMI---DDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLE 439 Query: 100 ASVNSVQWAPHE----------------------YGPLLLVASSDGKVSVVEFKENGTT 136 + ++ E Y L+ S DG + V E+ Sbjct: 440 PPIKLEDYSADEIPDPSIIPAPQPRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDKRK 498 Score = 37.5 bits (85), Expect = 0.007, Method: Composition-based stats. Identities = 13/88 (14%), Positives = 29/88 (32%), Gaps = 8/88 (9%) Query: 197 ESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDV 256 + T +GH V S ++ + D+ +++ K + + D Sbjct: 239 DKTYQGHLKAPLVVKAS---QDGKFVVTGGADKRLVVYNA-----ADLKPIKAFTQHRDA 290 Query: 257 LWRASWSLSGNVLALSGGDNKVTLWKEN 284 + ++ N L D V +W + Sbjct: 291 VTGLAFRRGTNQLYSCSKDRTVKVWSLD 318 >3JZG-A nrPDB Length = 402 Score = 79.5 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 51/310 (16%), Positives = 96/310 (30%), Gaps = 41/310 (13%) Query: 4 IANAHNELIHDAVLDYYGK----RLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRV 59 + +E + Y LA S I+I + T + I GH + + Sbjct: 100 VDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRI--INPITMQCIKHYVGHGNAINEL 157 Query: 60 DWAHPKFGTILASCSYDGKVLIWKEENGRWSQIA-VHAVHSASVNSVQWAPHEYGPLLLV 118 + HP+ +L S S D + +W + I H V S + G ++ Sbjct: 158 KF-HPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY--DLLGEKIMS 214 Query: 119 ASSDGKVSVV---------------EFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGE 163 D + + ++ N T P I + ++ ++ I + Sbjct: 215 CGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFI----SQKIHFPDFSTRDIHRNYV 270 Query: 164 HNGTKESRKFVTGGADNLVKIW---KYNSDAQTYVLES---TLEGHSD----WVRDVAWS 213 ++ +N + W K D T+ G D + + +S Sbjct: 271 DCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFS 330 Query: 214 PTVLLRSYLASVSQDRTCIIWTQDNEQG-PWKKTLLKEEKFPDVLWRASWSLSGNVLALS 272 + LA +Q +W + E K T L K + + S+S ++L Sbjct: 331 -MDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAV 389 Query: 273 GGDNKVTLWK 282 D + W Sbjct: 390 CDDASIWRWD 399 Score = 58.7 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 30/191 (15%), Positives = 67/191 (35%), Gaps = 12/191 (6%) Query: 94 VHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASW 153 + H+ + VQ+ H LV ++ G V ++ + ++ ++ ++ Sbjct: 49 LKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENF 108 Query: 154 APATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWS 213 ++ G+ +++I + T GH + + ++ + Sbjct: 109 Y----TCAWTYDSNTSHPLLAVAGSRGIIRI----INPITMQCIKHYVGHGNAINELKFH 160 Query: 214 PTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSG 273 P + L SVS+D +W + E D + A + L G + G Sbjct: 161 PRDP--NLLLSVSKDHALRLWNIQTDT--LVAIFGGVEGHRDEVLSADYDLLGEKIMSCG 216 Query: 274 GDNKVTLWKEN 284 D+ + LW+ N Sbjct: 217 MDHSLKLWRIN 227 >5BJS-A nrPDB Length = 605 Score = 76.8 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 38/187 (20%), Positives = 59/187 (31%), Gaps = 20/187 (10%) Query: 101 SVNSVQWAPHEYGPLLLVASSDGKV-----SVVEFKENGTTSPIIIDAHAIGVNSASWAP 155 V ++P P+ S V + N +I N AS Sbjct: 82 DVKFYPYSPPGAPPVFAATSKKHAVICRLTQTTDKDANPCEIIQLIRDDGNEANCASC-- 139 Query: 156 ATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPT 215 + + G + VK++ L TL GH + D+A SP Sbjct: 140 ------WSKDPITDQPLLCIAGNEGNVKVYNVTE----GKLYRTLVGHGGGINDLATSPA 189 Query: 216 VLLRSYLASVSQDRTCIIWTQDNEQGPWKK-TLLKEEKFPDVLWRASWSLSGNVLALSGG 274 +AS S D T IW+ E +L E L ++ +G + +G Sbjct: 190 NPY--IIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGH 247 Query: 275 DNKVTLW 281 D + LW Sbjct: 248 DQVINLW 254 Score = 74.8 bits (182), Expect = 4e-14, Method: Composition-based stats. Identities = 40/175 (22%), Positives = 65/175 (37%), Gaps = 20/175 (11%) Query: 23 RLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIW 82 L ++ +K++ V KL TL GH G + + P I+AS S D + IW Sbjct: 150 LLCIAGNEGNVKVYNVTE--GKLYRTLVGHGGGINDLA-TSPANPYIIASASDDTTIRIW 206 Query: 83 KE----ENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV---EFKENGT 135 E I HS + SV + H+ G +L A D +++ EF Sbjct: 207 SLAPEHEKQPCVCILGGEGHSYDLLSVAF--HDNGRYVLSAGHDQVINLWALPEFPNEHM 264 Query: 136 TSPIII--------DAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLV 182 PI+I + H V+ ++ I H T + +D+ + Sbjct: 265 EIPIVIYYPHFSSSEIHNNLVDCVAFYGDLILSRACHEDTIVLWRIEGFSSDDPI 319 Score = 61.4 bits (147), Expect = 5e-10, Method: Composition-based stats. Identities = 30/150 (20%), Positives = 55/150 (36%), Gaps = 23/150 (15%) Query: 7 AHNELIHDAVLDYYGKR-LATCSSDKTIKIFEV--EGETHKLIDTL--TGHEGPVWRVDW 61 H I+D +A+ S D TI+I+ + E E + L GH + V + Sbjct: 176 GHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAF 235 Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAV-----------HAVHSASVNSVQWAPH 110 H G + S +D + +W + + +H+ V+ V + Sbjct: 236 -HDN-GRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAF--- 290 Query: 111 EYGPLLLV-ASSDGKVSVVEFKENGTTSPI 139 YG L+L A + + + + + PI Sbjct: 291 -YGDLILSRACHEDTIVLWRIEGFSSDDPI 319 Score = 42.5 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 15/99 (15%), Positives = 35/99 (35%), Gaps = 18/99 (18%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIF---EVEGETHK--------LIDTL 49 ++ H+ + G+ + + D+ I ++ E E + + Sbjct: 219 CILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSS 278 Query: 50 TGHEGPVWRVDWAHPKFGTILAS--CSYDGKVLIWKEEN 86 H V V + +G ++ S C D +++W+ E Sbjct: 279 EIHNNLVDCVAF----YGDLILSRACHED-TIVLWRIEG 312 Score = 36.3 bits (82), Expect = 0.016, Method: Composition-based stats. Identities = 12/82 (14%), Positives = 30/82 (36%), Gaps = 5/82 (6%) Query: 211 AWSPT-VLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVL 269 WS + + L + ++ +G +TL+ + L + + ++ Sbjct: 139 CWSKDPITDQPLLCIAGNEGNVKVYN--VTEGKLYRTLVGHGGGINDLATSPANPY--II 194 Query: 270 ALSGGDNKVTLWKENLEGKWEP 291 A + D + +W E + +P Sbjct: 195 ASASDDTTIRIWSLAPEHEKQP 216 >5WLC-LJ nrPDB Length = 513 Score = 76.0 bits (185), Expect = 2e-14, Method: Composition-based stats. Identities = 37/224 (16%), Positives = 71/224 (31%), Gaps = 24/224 (10%) Query: 5 ANAHNELIHDAVLDYYGKR-LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 NA H + LAT S D+ +++++ ++ LTG V + + Sbjct: 120 INASTHPTHVTKFHTQDNKILATASDDRVTRLWDISNAYEPQLE-LTGATDYVRTLSFI- 177 Query: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASV-NSVQWAPHEYGPLLLVASSD 122 P ++A+ SYDG + ++ + + I H V N + +P + +V+ Sbjct: 178 PAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLN-HDQPVENVIAVSPTQ-----IVSCGG 231 Query: 123 GKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLV 182 V + N V + E+ + + D V Sbjct: 232 NNFKVWDLTSNKKLYERGNF--NKAVTCLDY--------VENFDSPMQSALIASSLDGHV 281 Query: 183 KIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVS 226 K++ + Q S V A SP+ + Sbjct: 282 KVFDPLDNFQVKFGWKF----SGPVLSCAVSPSTAQGNRHLVAG 321 Score = 48.7 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 33/201 (16%), Positives = 61/201 (30%), Gaps = 26/201 (12%) Query: 87 GRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAI 146 +++ + H+ SV + + P + +S+ V F Sbjct: 28 RQYTSAQLVKEHN-SVTHISFNPQHPHDFAVTSST----RVQIFSSRTRQVIKTFSRFKD 82 Query: 147 GVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDW 206 V SAS+ + + G A LV ++ + + +T +L H Sbjct: 83 VVYSASF-------------RSDGKLLCAGDATGLVSVYD-SYNPRTILLSINASTHPTH 128 Query: 207 VRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSG 266 V LA+ S DR +W N P + L + L + Sbjct: 129 VTKF----HTQDNKILATASDDRVTRLWDISNAYEP-QLELTGATDYVRTLSFIPAAPH- 182 Query: 267 NVLALSGGDNKVTLWKENLEG 287 ++A D + L+ G Sbjct: 183 -LVATGSYDGLIRLYDTRSSG 202 >2PM9-A nrPDB Length = 416 Score = 75.2 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 41/286 (14%), Positives = 91/286 (31%), Gaps = 34/286 (11%) Query: 9 NELIHDAVLDYYGKRLATCSSDKTIKIFEVE--GETHKLIDTLTGHEGPVWRVDWAHPKF 66 + +D + K +A + +++++ + + H V V + + K Sbjct: 67 DSKFNDLDWSHNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKF-NAKQ 125 Query: 67 GTILASCSYDGKVLIWKEENGRWSQIA-------VHAVHSASVNSVQWAPHEYGPLLLVA 119 +LAS +G++ IW S V S+ W + A Sbjct: 126 DNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWN-QSLAHVFASA 184 Query: 120 SSDGKVSVVEFKENGTTSPIIIDAHAIGVNS----ASWAPATIEEDGEHNGTKESRKFVT 175 S S+ + K + + G+ W P G+ Sbjct: 185 GSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSD------- 237 Query: 176 GGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 D + IW + L++ +GH + + W L S +D T ++W Sbjct: 238 --NDPSILIWDLRN--ANTPLQTLNQGHQKGILSLDWCHQD--EHLLLSSGRDNTVLLWN 291 Query: 236 QDNEQGPWKKTLLKEEKFPDVLWRASWSLSG-NVLALSGGDNKVTL 280 ++ + + + ++ ++ ++ A + DNK+ + Sbjct: 292 PESAEQLSQFPARG-----NWCFKTKFAPEAPDLFACASFDNKIEV 332 Score = 72.5 bits (176), Expect = 2e-13, Method: Composition-based stats. Identities = 55/289 (19%), Positives = 111/289 (38%), Gaps = 33/289 (11%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEV-EGETHKLIDTLTGHEGPVWRVDWAHPK 65 +H+++ G A S+D +++++ + ++ K I +L + +DW+H Sbjct: 21 SHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQV-DSKFNDLDWSHNN 79 Query: 66 FGTILASCSYDGKVLIWKEE--NGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 I+A +G + ++ N + +A + HS+SV +V++ + +L ++G Sbjct: 80 K--IIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQD-NVLASGGNNG 136 Query: 124 KVSVVEFKENGTT-------SPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTG 176 ++ + + + + +P + V S +W + F + Sbjct: 137 EIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHV------------FASA 184 Query: 177 GADNLVKIWKYNSDAQTYVLESTLE--GHSDWVRDVAWSPTVLLRSYLASVSQ-DRTCII 233 G+ N IW + + L T G + V W P R A+ S D + +I Sbjct: 185 GSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILI 244 Query: 234 WTQDNEQGPWKKTLLKEEKFPDVLWRASWS-LSGNVLALSGGDNKVTLW 281 W N P + + + W ++L SG DN V LW Sbjct: 245 WDLRNANTPLQ---TLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLW 290 Score = 67.1 bits (162), Expect = 9e-12, Method: Composition-based stats. Identities = 34/144 (23%), Positives = 54/144 (37%), Gaps = 6/144 (4%) Query: 25 ATCSS-DKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 AT S D +I I+++ L GH+ + +DW H + +L S D VL+W Sbjct: 233 ATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCH-QDEHLLLSSGRDNTVLLWN 291 Query: 84 EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKE-NGTTSPIIID 142 E+ Q++ ++AP E L AS D K+ V + T + Sbjct: 292 PESAE--QLSQFPARGNWCFKTKFAP-EAPDLFACASFDNKIEVQTLQNLTNTLDEQETE 348 Query: 143 AHAIGVNSASWAPATIEEDGEHNG 166 + W + EE E Sbjct: 349 TKQQESETDFWNNVSREESKEKPS 372 Score = 56.4 bits (134), Expect = 1e-08, Method: Composition-based stats. Identities = 40/245 (16%), Positives = 71/245 (28%), Gaps = 39/245 (15%) Query: 60 DWAHPKFGTILASC----------SYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAP 109 W+H K +L S S D + +W + + N + W+ Sbjct: 19 AWSHDKIP-LLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLDWS- 76 Query: 110 HEYGPLLLVASSDGKVSVVEFKE--NGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGT 167 ++ A +G + + E N S H+ V + + Sbjct: 77 -HNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFN------------A 123 Query: 168 KESRKFVTGGADNLVKIWKYNSDAQTYVLESTL-----EGHSDWVRDVAWSPTVLLRSYL 222 K+ +GG + + IW N ++ + L D V +AW L Sbjct: 124 KQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAW--NQSLAHVF 181 Query: 223 ASVSQDRTCIIWTQDNEQGPWKKTLLK-EEKFPDVLWRASWSLSGN--VLALSGGDN--K 277 AS IW ++ + L W + V +G DN Sbjct: 182 ASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPS 241 Query: 278 VTLWK 282 + +W Sbjct: 242 ILIWD 246 Score = 36.3 bits (82), Expect = 0.015, Method: Composition-based stats. Identities = 22/136 (16%), Positives = 53/136 (38%), Gaps = 7/136 (5%) Query: 150 SASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRD 209 +A++A + + +GT D+ +++W + A + ++L+ S + D Sbjct: 15 TATFAWSHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLA-ADSEKPIASLQVDSKF-ND 72 Query: 210 VAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWS-LSGNV 268 + WS + + + D + NE ++ + + ++ NV Sbjct: 73 LDWSHNNK----IIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNV 128 Query: 269 LALSGGDNKVTLWKEN 284 LA G + ++ +W N Sbjct: 129 LASGGNNGEIFIWDMN 144 >5OQL-L nrPDB Length = 557 Score = 74.1 bits (180), Expect = 8e-14, Method: Composition-based stats. Identities = 45/266 (16%), Positives = 78/266 (29%), Gaps = 37/266 (13%) Query: 23 RLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIW 82 +L + S T + + T T P+ + + T L S S Sbjct: 12 KLPSGPSPITAEQRYWRSFKKQKSHTSTA-NWPISHISFPASLGTTALVSSSLVAAAKTN 70 Query: 83 KE------------ENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEF 130 + + + + + P G +L+ G++ V + Sbjct: 71 DLFAVTAGPRVEIFSIRKREPLKTIGRFDSEAHCGEIRPD--GRVLVAGEDTGRMQVFDV 128 Query: 131 KENGTTSPIIIDA-HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNS 189 + + H V W+P E ++ D V++W S Sbjct: 129 GQGTRAVILKTWHIHKQPVWVTKWSP------------TELTTLMSCSDDKTVRLWDLPS 176 Query: 190 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLK 249 + T GH+D+VR A+ P + L S S D T +W G Sbjct: 177 NDPT----RLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVM----- 227 Query: 250 EEKFPDVLWRASWSLSGNVLALSGGD 275 K D + SG L + G+ Sbjct: 228 TFKHADPIEDVLPLPSGTTLLAASGN 253 Score = 73.3 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 28/132 (21%), Positives = 45/132 (34%), Gaps = 11/132 (8%) Query: 159 EEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLL 218 E + R V G ++++ + V+ T H V WSPT L Sbjct: 100 SEAHCGEIRPDGRVLVAGEDTGRMQVFDVGQGTR-AVILKTWHIHKQPVWVTKWSPTEL- 157 Query: 219 RSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASW---SLSGNVLALSGGD 275 + L S S D+T +W + T D + ++ S + N+L D Sbjct: 158 -TTLMSCSDDKTVRLWDLPSNDPTRLFT-----GHTDYVRCGAFMPGSANSNLLVSGSYD 211 Query: 276 NKVTLWKENLEG 287 V +W G Sbjct: 212 ETVRVWDARAPG 223 Score = 66.0 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 24/130 (18%), Positives = 48/130 (36%), Gaps = 12/130 (9%) Query: 4 IANAHNELIHDAVLDY---YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 + H + + L + S D+T+++++ ++ T H P+ V Sbjct: 182 LFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVM-TFK-HADPIEDV- 238 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 P T+LA+ + + + + + H +V S+ A G ++ S Sbjct: 239 LPLPSGTTLLAASG--NAISVLDLVAAK--PLRLITNHQKTVTSLSLASQ--GRRVVSGS 292 Query: 121 SDGKVSVVEF 130 DG V V E Sbjct: 293 LDGHVKVFET 302 >6EM1-m nrPDB Length = 807 Score = 73.3 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 51/298 (17%), Positives = 94/298 (31%), Gaps = 33/298 (11%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGP----V 56 I H + +D G LAT S D T++++E+ TL E + Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHI 488 Query: 57 WRVDWAHPKFGTILASC-SYDGKVLI-----WKEENGRWSQIAVHAVHSAS--VNSVQWA 108 ++W ILA + +++ + EN ++I + V Sbjct: 489 ECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLE 548 Query: 109 PHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTK 168 +E G DG+ + + + + + + + + Sbjct: 549 VNENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHR 604 Query: 169 ESRKFVTG---GADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASV 225 + FVT + V I + + + + + D + P + L Sbjct: 605 KGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKS----KGIIMDAKFHP---FKPQLFVC 657 Query: 226 SQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKE 283 SQ R I D Q K LL ++ L + G+ L S D +V LW + Sbjct: 658 SQ-RYVRI--YDLSQQILVKKLLPGARW---LSKIDIHPRGDNLIASSFDKRV-LWHD 708 Score = 61.8 bits (148), Expect = 3e-10, Method: Composition-based stats. Identities = 41/244 (16%), Positives = 75/244 (30%), Gaps = 48/244 (19%) Query: 9 NELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGH--------EGPVWRVD 60 + + G T D G T LI ++ H + Sbjct: 594 KKTVKKLSWHRKGDYFVTVQPD--------SGNTSVLIHQVSKHLTQSPFKKSKGIIMDA 645 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 HP + CS V I+ + + + ++ + P G L+ +S Sbjct: 646 KFHPFKPQLFV-CSQ-RYVRIYDLS--QQILVKKLLPGARWLSKIDIHP--RGDNLIASS 699 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 D +V + + +T + H V S ++ K+ F + D Sbjct: 700 FDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFH-------------KKLPLFSSAADDG 745 Query: 181 LVKIWK---YNSDAQTYVLE--STLEGHSDW----VRDVAWSPTVLLRSYLASVSQDRTC 231 + ++ Y+ + ++ L GH V D W P ++L S D T Sbjct: 746 TIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPRE---AWLFSAGADNTA 802 Query: 232 IIWT 235 +WT Sbjct: 803 RLWT 806 Score = 52.1 bits (123), Expect = 3e-07, Method: Composition-based stats. Identities = 38/244 (15%), Positives = 67/244 (27%), Gaps = 47/244 (19%) Query: 77 GKVLIWKEENGRWSQ--IAVHAVHSASVNSVQWAPHEYGPLLLVA---SSDGKVSVVEFK 131 +V W + + + + I + +V + W H G + S + V + + Sbjct: 570 KQVAQWNKPSQKQLEKDICITISCKKTVKKLSW--HRKGDYFVTVQPDSGNTSVLIHQVS 627 Query: 132 ENGTTSPIII-DAHAIGVNSASWAPATIEEDGEH-------------------------N 165 ++ T SP + + P + + Sbjct: 628 KHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDLSQQILVKKLLPGARWLSKID 687 Query: 166 GTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASV 225 + D V +W A T TL H VR V + +S Sbjct: 688 IHPRGDNLIASSFDKRV-LWHDLDLASTPY--KTLRYHEKAVRSVNFH---KKLPLFSSA 741 Query: 226 SQDRTCIIWTQDNEQGPWK-------KTLLKEEKFPDV-LWRASWSLSGNVLALSGGDNK 277 + D T ++ K K L + + + A W L +G DN Sbjct: 742 ADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNT 801 Query: 278 VTLW 281 LW Sbjct: 802 ARLW 805 Score = 41.3 bits (95), Expect = 5e-04, Method: Composition-based stats. Identities = 17/88 (19%), Positives = 28/88 (31%), Gaps = 13/88 (14%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFE-------VEGETHKLIDTLTGH----EGPV 56 H + + ++ + D TI +F ++ + LTGH V Sbjct: 722 HEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGV 781 Query: 57 WRVDWAHPKFGTILASCSYDGKVLIWKE 84 W HP+ L S D +W Sbjct: 782 LDAIW-HPRE-AWLFSAGADNTARLWTT 807 Score = 28.2 bits (61), Expect = 4.7, Method: Composition-based stats. Identities = 6/36 (16%), Positives = 14/36 (38%), Gaps = 4/36 (11%) Query: 5 ANAHNEL----IHDAVLDYYGKRLATCSSDKTIKIF 36 H + + DA+ L + +D T +++ Sbjct: 770 LTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 >6BX3-B nrPDB Length = 412 Score = 72.9 bits (177), Expect = 1e-13, Method: Composition-based stats. Identities = 41/294 (13%), Positives = 92/294 (31%), Gaps = 20/294 (6%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 + AH I G+ L T S D +IK++++ + L + + P+W W Sbjct: 66 MLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRF--DSPIWGCQWLD 123 Query: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 K +A+ + + N + + + + P L+ + Sbjct: 124 AKRRLCVATIFEESDAYVIDFSNDPVASLLS----KSDEKQLSSTPDHGYVLVCTVHT-K 178 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 +++ + T ++ + +D ++ Sbjct: 179 HPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIR 238 Query: 184 IWKYNSDAQTYVLESTLEG-HSDWVRDVAWSP---TVLLRSYLAS---VSQDRTCIIWTQ 236 ++ + D + +E TLE + D + + W+ + YL + S IW Sbjct: 239 QYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWET 298 Query: 237 DNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGD-NKVTLWKENLEGKW 289 + + E + L +W + +G + V +W + KW Sbjct: 299 TSGT-----LVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKW 347 Score = 72.2 bits (175), Expect = 2e-13, Method: Composition-based stats. Identities = 42/252 (16%), Positives = 85/252 (33%), Gaps = 14/252 (5%) Query: 14 DAVLDYYGKRLATCSSDKTIKIFEVEGETHKLID--TLTGHEGPVWRVDWAHPKFGTILA 71 G LA ++ + I++++ + L H P+ + W+ G +L Sbjct: 30 CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD--GRLLL 87 Query: 72 SCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFK 131 + S D + +W + S+ + + QW + + + V++F Sbjct: 88 TSSRDWSIKLWDLS--KPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFS 145 Query: 132 ENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDA 191 + S + S P TK + G + + +K++S Sbjct: 146 NDPVASLLSKSDEKQ----LSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLY 201 Query: 192 QTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEE 251 QT +L+ S ++ + S LA DRT + + L E Sbjct: 202 QT-ECIHSLKITSSNIKHLIVSQN---GERLAINCSDRTIRQYEISIDDENSAVELTLEH 257 Query: 252 KFPDVLWRASWS 263 K+ DV+ + W+ Sbjct: 258 KYQDVINKLQWN 269 Score = 47.1 bits (110), Expect = 8e-06, Method: Composition-based stats. Identities = 32/235 (13%), Positives = 77/235 (32%), Gaps = 21/235 (8%) Query: 58 RVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQI--AVHAVHSASVNSVQWAPHEYGPL 115 + ++ G LA +G ++I+ + R + + H + S+ W+P G L Sbjct: 30 CLQFSP--CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD--GRL 85 Query: 116 LLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVT 175 LL +S D + + + + + P+ + W A + + Sbjct: 86 LLTSSRDWSIKLWDLSKP--SKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 143 Query: 176 GGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 D + + + + Q S+ H + T + T W Sbjct: 144 FSNDPVASLLSKSDEKQ----LSSTPDHGYVLVCTV--HTKHPNIIIV-----GTSKGWL 192 Query: 236 QDNEQGPWKKT--LLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGK 288 + +T + + + S +G LA++ D + ++ +++ + Sbjct: 193 DFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDE 247 >6C0F-s nrPDB Length = 807 Score = 72.9 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 51/298 (17%), Positives = 94/298 (31%), Gaps = 33/298 (11%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGP----V 56 I H + +D G LAT S D T++++E+ TL E + Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHI 488 Query: 57 WRVDWAHPKFGTILASC-SYDGKVLI-----WKEENGRWSQIAVHAVHSAS--VNSVQWA 108 ++W ILA + +++ + EN ++I + V Sbjct: 489 ECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLE 548 Query: 109 PHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTK 168 +E G DG+ + + + + + + + + Sbjct: 549 VNENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHR 604 Query: 169 ESRKFVTG---GADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASV 225 + FVT + V I + + + + + D + P + L Sbjct: 605 KGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKS----KGIIMDAKFHP---FKPQLFVC 657 Query: 226 SQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKE 283 SQ R I D Q K LL ++ L + G+ L S D +V LW + Sbjct: 658 SQ-RYVRI--YDLSQQILVKKLLPGARW---LSKIDIHPRGDNLIASSFDKRV-LWHD 708 Score = 61.8 bits (148), Expect = 4e-10, Method: Composition-based stats. Identities = 41/244 (16%), Positives = 75/244 (30%), Gaps = 48/244 (19%) Query: 9 NELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGH--------EGPVWRVD 60 + + G T D G T LI ++ H + Sbjct: 594 KKTVKKLSWHRKGDYFVTVQPD--------SGNTSVLIHQVSKHLTQSPFKKSKGIIMDA 645 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 HP + CS V I+ + + + ++ + P G L+ +S Sbjct: 646 KFHPFKPQLFV-CSQ-RYVRIYDLS--QQILVKKLLPGARWLSKIDIHP--RGDNLIASS 699 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 D +V + + +T + H V S ++ K+ F + D Sbjct: 700 FDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFH-------------KKLPLFSSAADDG 745 Query: 181 LVKIWK---YNSDAQTYVLE--STLEGHSDW----VRDVAWSPTVLLRSYLASVSQDRTC 231 + ++ Y+ + ++ L GH V D W P ++L S D T Sbjct: 746 TIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPRE---AWLFSAGADNTA 802 Query: 232 IIWT 235 +WT Sbjct: 803 RLWT 806 Score = 51.7 bits (122), Expect = 3e-07, Method: Composition-based stats. Identities = 38/244 (15%), Positives = 67/244 (27%), Gaps = 47/244 (19%) Query: 77 GKVLIWKEENGRWSQ--IAVHAVHSASVNSVQWAPHEYGPLLLVA---SSDGKVSVVEFK 131 +V W + + + + I + +V + W H G + S + V + + Sbjct: 570 KQVAQWNKPSQKQLEKDICITISCKKTVKKLSW--HRKGDYFVTVQPDSGNTSVLIHQVS 627 Query: 132 ENGTTSPIII-DAHAIGVNSASWAPATIEEDGEH-------------------------N 165 ++ T SP + + P + + Sbjct: 628 KHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDLSQQILVKKLLPGARWLSKID 687 Query: 166 GTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASV 225 + D V +W A T TL H VR V + +S Sbjct: 688 IHPRGDNLIASSFDKRV-LWHDLDLASTPY--KTLRYHEKAVRSVNFH---KKLPLFSSA 741 Query: 226 SQDRTCIIWTQDNEQGPWK-------KTLLKEEKFPDV-LWRASWSLSGNVLALSGGDNK 277 + D T ++ K K L + + + A W L +G DN Sbjct: 742 ADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNT 801 Query: 278 VTLW 281 LW Sbjct: 802 ARLW 805 Score = 41.3 bits (95), Expect = 5e-04, Method: Composition-based stats. Identities = 17/88 (19%), Positives = 28/88 (31%), Gaps = 13/88 (14%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFE-------VEGETHKLIDTLTGH----EGPV 56 H + + ++ + D TI +F ++ + LTGH V Sbjct: 722 HEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGV 781 Query: 57 WRVDWAHPKFGTILASCSYDGKVLIWKE 84 W HP+ L S D +W Sbjct: 782 LDAIW-HPRE-AWLFSAGADNTARLWTT 807 Score = 28.2 bits (61), Expect = 4.9, Method: Composition-based stats. Identities = 6/36 (16%), Positives = 14/36 (38%), Gaps = 4/36 (11%) Query: 5 ANAHNEL----IHDAVLDYYGKRLATCSSDKTIKIF 36 H + + DA+ L + +D T +++ Sbjct: 770 LTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 >6CB1-s nrPDB Length = 569 Score = 72.2 bits (175), Expect = 2e-13, Method: Composition-based stats. Identities = 51/298 (17%), Positives = 94/298 (31%), Gaps = 33/298 (11%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGP----V 56 I H + +D G LAT S D T++++E+ TL E + Sbjct: 191 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHI 250 Query: 57 WRVDWAHPKFGTILASC-SYDGKVLI-----WKEENGRWSQIAVHAVHSAS--VNSVQWA 108 ++W ILA + +++ + EN ++I + V Sbjct: 251 ECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLE 310 Query: 109 PHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTK 168 +E G DG+ + + + + + + + + Sbjct: 311 VNENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHR 366 Query: 169 ESRKFVTG---GADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASV 225 + FVT + V I + + + + + D + P + L Sbjct: 367 KGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKS----KGIIMDAKFHP---FKPQLFVC 419 Query: 226 SQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKE 283 SQ R I D Q K LL ++ L + G+ L S D +V LW + Sbjct: 420 SQ-RYVRI--YDLSQQILVKKLLPGARW---LSKIDIHPRGDNLIASSFDKRV-LWHD 470 Score = 61.0 bits (146), Expect = 6e-10, Method: Composition-based stats. Identities = 41/244 (16%), Positives = 75/244 (30%), Gaps = 48/244 (19%) Query: 9 NELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGH--------EGPVWRVD 60 + + G T D G T LI ++ H + Sbjct: 356 KKTVKKLSWHRKGDYFVTVQPD--------SGNTSVLIHQVSKHLTQSPFKKSKGIIMDA 407 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 HP + CS V I+ + + + ++ + P G L+ +S Sbjct: 408 KFHPFKPQLFV-CSQ-RYVRIYDLS--QQILVKKLLPGARWLSKIDIHP--RGDNLIASS 461 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 D +V + + +T + H V S ++ K+ F + D Sbjct: 462 FDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFH-------------KKLPLFSSAADDG 507 Query: 181 LVKIWK---YNSDAQTYVLE--STLEGHSDW----VRDVAWSPTVLLRSYLASVSQDRTC 231 + ++ Y+ + ++ L GH V D W P ++L S D T Sbjct: 508 TIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPRE---AWLFSAGADNTA 564 Query: 232 IIWT 235 +WT Sbjct: 565 RLWT 568 Score = 51.4 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 38/244 (15%), Positives = 67/244 (27%), Gaps = 47/244 (19%) Query: 77 GKVLIWKEENGRWSQ--IAVHAVHSASVNSVQWAPHEYGPLLLVA---SSDGKVSVVEFK 131 +V W + + + + I + +V + W H G + S + V + + Sbjct: 332 KQVAQWNKPSQKQLEKDICITISCKKTVKKLSW--HRKGDYFVTVQPDSGNTSVLIHQVS 389 Query: 132 ENGTTSPIII-DAHAIGVNSASWAPATIEEDGEH-------------------------N 165 ++ T SP + + P + + Sbjct: 390 KHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDLSQQILVKKLLPGARWLSKID 449 Query: 166 GTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASV 225 + D V +W A T TL H VR V + +S Sbjct: 450 IHPRGDNLIASSFDKRV-LWHDLDLASTPY--KTLRYHEKAVRSVNFH---KKLPLFSSA 503 Query: 226 SQDRTCIIWTQDNEQGPWK-------KTLLKEEKFPDV-LWRASWSLSGNVLALSGGDNK 277 + D T ++ K K L + + + A W L +G DN Sbjct: 504 ADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNT 563 Query: 278 VTLW 281 LW Sbjct: 564 ARLW 567 Score = 41.0 bits (94), Expect = 6e-04, Method: Composition-based stats. Identities = 17/88 (19%), Positives = 28/88 (31%), Gaps = 13/88 (14%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFE-------VEGETHKLIDTLTGH----EGPV 56 H + + ++ + D TI +F ++ + LTGH V Sbjct: 484 HEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGV 543 Query: 57 WRVDWAHPKFGTILASCSYDGKVLIWKE 84 W HP+ L S D +W Sbjct: 544 LDAIW-HPRE-AWLFSAGADNTARLWTT 569 Score = 33.2 bits (74), Expect = 0.14, Method: Composition-based stats. Identities = 11/84 (13%), Positives = 26/84 (30%), Gaps = 2/84 (2%) Query: 146 IGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYV--LESTLEGH 203 + ++ + + TG D V++W+ + + Y L E Sbjct: 187 FPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENP 246 Query: 204 SDWVRDVAWSPTVLLRSYLASVSQ 227 + + W+P +V + Sbjct: 247 DYHIECIEWNPDANNGILAVAVGE 270 Score = 27.9 bits (60), Expect = 5.3, Method: Composition-based stats. Identities = 6/36 (16%), Positives = 14/36 (38%), Gaps = 4/36 (11%) Query: 5 ANAHNEL----IHDAVLDYYGKRLATCSSDKTIKIF 36 H + + DA+ L + +D T +++ Sbjct: 532 LTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 567 >5CXB-B nrPDB Length = 369 Score = 69.1 bits (167), Expect = 2e-12, Method: Composition-based stats. Identities = 58/362 (16%), Positives = 101/362 (27%), Gaps = 89/362 (24%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 I H + +D G LAT D T++++E+ L G + V V W Sbjct: 14 QTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNG-DEAVNTVRW 72 Query: 62 AHPKFGTIL-ASCSYDGKVLI------------------------------------WKE 84 K IL A+ D ++I KE Sbjct: 73 RPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPGKE 132 Query: 85 ENGRWSQ---------IAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS--------- 126 G+W++ + + +++ ++ W H G S G+ S Sbjct: 133 PPGKWARPGTRLEDEGVLLRITVRSTIKAISW--HRRGDHFATVSPSGQRSSVAIHTLSK 190 Query: 127 ------------VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFV 174 + + P+ A + + + + S V Sbjct: 191 HLTQIPFRKLNGLAQTASFHPLRPLFFVATQRSIRCYDLQKLELVKIVQPGAKWISSFDV 250 Query: 175 TGGADNLV-------KIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQ 227 G DNLV +W + T+ H++ +R V + L A S Sbjct: 251 HPGGDNLVVGSYDKRLLWHDLDLSNRP--YKTMRFHTEAIRAVRFHKGGL--PLFADASD 306 Query: 228 DRTCIIW-------TQDNEQGPWKKTLLKEEKFPDV-LWRASWSLSGNVLALSGGDNKVT 279 D + I+ +N K L + + + W +G D Sbjct: 307 DGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWCVSAGADGTAR 366 Query: 280 LW 281 LW Sbjct: 367 LW 368 Score = 55.2 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 28/139 (20%), Positives = 50/139 (35%), Gaps = 15/139 (10%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 +V I + I + G L S DK + ++ +++ T+ H + V Sbjct: 234 LVKIVQPGAKWISSFDVHPGGDNLVVGSYDKRL-LWHDLDLSNRPYKTMRFHTEAIRAVR 292 Query: 61 WAHPKFGTILASCSYDGKVLIW-------KEENGRWSQIAVHAVHSAS----VNSVQWAP 109 + H + A S DG + I+ + EN + + H V + W P Sbjct: 293 F-HKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHP 351 Query: 110 HEYGPLLLVASSDGKVSVV 128 E P + A +DG + Sbjct: 352 RE--PWCVSAGADGTARLW 368 Score = 47.5 bits (111), Expect = 6e-06, Method: Composition-based stats. Identities = 21/89 (23%), Positives = 34/89 (38%), Gaps = 10/89 (11%) Query: 195 VLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFP 254 V ++ GH VR VA PT LA+ D T +W + W L +E Sbjct: 12 VQQTIFRGHEGRVRSVAIDPT---GVALATGGDDGTVRVWELLTGRQVWSVKLNGDE--- 65 Query: 255 DVLWRASWSLSGN---VLALSGGDNKVTL 280 + W + + + A +G D + + Sbjct: 66 -AVNTVRWRPTKDTFILAAAAGEDIFLMI 93 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 17/65 (26%), Positives = 22/65 (33%), Gaps = 3/65 (4%) Query: 91 QIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNS 150 Q + H V SV P G L DG V V E + ++ VN+ Sbjct: 13 QQTIFRGHEGRVRSVAIDPT--GVALATGGDDGTVRVWELLTGRQVWSVKLNG-DEAVNT 69 Query: 151 ASWAP 155 W P Sbjct: 70 VRWRP 74 Score = 42.1 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 24/100 (24%), Positives = 35/100 (35%), Gaps = 16/100 (16%) Query: 129 EFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN 188 E K T I H V S + P + TGG D V++W+ Sbjct: 5 ELKPFPTVQQTIFRGHEGRVRSVAIDPTGVA-------------LATGGDDGTVRVWELL 51 Query: 189 SDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQD 228 + Q + + L G + V V W PT A+ +D Sbjct: 52 TGRQVWSV--KLNG-DEAVNTVRWRPTKDTFILAAAAGED 88 Score = 37.1 bits (84), Expect = 0.009, Method: Composition-based stats. Identities = 7/31 (22%), Positives = 12/31 (38%) Query: 252 KFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 + + +G LA G D V +W+ Sbjct: 19 GHEGRVRSVAIDPTGVALATGGDDGTVRVWE 49 >5MWJ-A nrPDB Length = 337 Score = 68.7 bits (166), Expect = 3e-12, Method: Composition-based stats. Identities = 43/321 (13%), Positives = 85/321 (26%), Gaps = 82/321 (25%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK-- 65 H E++ + + + T +K++++ G++ PV ++D + Sbjct: 50 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHP---------GNKSPVSQLDCLNRDNY 99 Query: 66 --------FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLL 117 G L + IW A + + ++ +P Sbjct: 100 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCF-- 157 Query: 118 VASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGG 177 SDG ++V + T H G + + + K TGG Sbjct: 158 SCCSDGNIAVWDLHN--QTLVRQFQGHTDGASCIDIS-------------NDGTKLWTGG 202 Query: 178 ADNLVKIWKYNSDAQTYVLEST------------------------------------LE 201 DN V+ W Q + T L Sbjct: 203 LDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLH 262 Query: 202 GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRAS 261 H V + ++ + S +D W + + K + Sbjct: 263 LHESCVLSLKFA---YCGKWFVSTGKDNLLNAWR------TPYGASIFQSKESSSVLSCD 313 Query: 262 WSLSGNVLALSGGDNKVTLWK 282 S+ + GD K T+++ Sbjct: 314 ISVDDKYIVTGSGDKKATVYE 334 Score = 47.9 bits (112), Expect = 5e-06, Method: Composition-based stats. Identities = 22/187 (11%), Positives = 56/187 (29%), Gaps = 26/187 (13%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 +V H + + G +L T D T++ +++ ++ + Sbjct: 175 LVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDF---TSQIFSLG 231 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 + G LA V + + + +H H + V S+++A G + Sbjct: 232 YCP--TGEWLAVGMESSNVEV--LHVNKPDKYQLHL-HESCVLSLKFA--YCGKWFVSTG 284 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 D ++ + + + + + + + VTG D Sbjct: 285 KDNLLNAWRTPYGASIFQSKESSSVLSCD----------------ISVDDKYIVTGSGDK 328 Query: 181 LVKIWKY 187 +++ Sbjct: 329 KATVYEV 335 >4E5Z-B nrPDB Length = 436 Score = 67.5 bits (163), Expect = 6e-12, Method: Composition-based stats. Identities = 45/235 (19%), Positives = 84/235 (35%), Gaps = 27/235 (11%) Query: 57 WRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLL 116 + W HP + +A S G +++W S+ +++ P Sbjct: 123 TSLAW-HPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFY 181 Query: 117 LVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTG 176 S +G + +FK N + + A + +N + + + SR VTG Sbjct: 182 AS-SMEGTTRLQDFKGN----ILRVFASSDTINIWFCS---------LDVSASSRMVVTG 227 Query: 177 GADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ 236 DN+ + N D L H V VA +P +LA+ S D+T IW Sbjct: 228 --DNVGNVILLNMD---GKELWNLRMHKKKVTHVALNPCCDW--FLATASVDQTVKIWDL 280 Query: 237 DNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEP 291 +G + P + A +S G L + +++ ++ + +W+ Sbjct: 281 RQVRGKASFLYSLPHRHP--VNAACFSPDGARLLTTDQKSEIRVYSAS---QWDC 330 Score = 55.2 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 33/194 (17%), Positives = 65/194 (33%), Gaps = 16/194 (8%) Query: 8 HNELIHDAVLDYYGKR-LATCSSDKTIKIFEVEGETHK--LIDTLTGHEGPVWRVDWAHP 64 H + + L+ LAT S D+T+KI+++ K + +L H PV ++ Sbjct: 249 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP-HRHPVNAACFSPD 307 Query: 65 KFGTILASCSYDGKVLI-----WKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA 119 G L + ++ + W G H H + + W P Y +++ Sbjct: 308 --GARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA-AWHP-RYNLIVVGR 363 Query: 120 SSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGAD 179 D E T + D ++ + + P + + + Sbjct: 364 YPDPNFKSCTPYELRTID--VFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASA-MG 420 Query: 180 NLVKIWKYNSDAQT 193 + IW +A+T Sbjct: 421 YHILIWSEQEEART 434 >5YZG-2 nrPDB Length = 646 Score = 66.8 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 34/230 (14%), Positives = 67/230 (29%), Gaps = 38/230 (16%) Query: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 + + S+DG V WK+ + H + S+ + G L D + V Sbjct: 102 DFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSE--GALFCSVGDDKAMKV 159 Query: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 + + + + I + + I+ Sbjct: 160 FDVVNFDMINMLKLGYFPGQCEWIYCPGDAISSVAASEKSTG-----------KIFIYDG 208 Query: 188 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT--CIIW----------- 234 D Q + L H+ + + +P Y A VS D++ W Sbjct: 209 RGDNQPLHIFDKL--HTSPLTQIRLNP-----VYKAVVSSDKSGMIEYWTGPPHEYKFPK 261 Query: 235 --TQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 + + K + +P + +S G +A G D KV +++ Sbjct: 262 NVNWEYKTDTDLYEFAKCKAYPTSVC---FSPDGKKIATIGSDRKVRIFR 308 Score = 57.1 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 31/223 (13%), Positives = 62/223 (27%), Gaps = 25/223 (11%) Query: 22 KRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLI 81 + T S D +K ++ E + + H G + + + G + S D + + Sbjct: 102 DFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSS--EGALFCSVGDDKAMKV 159 Query: 82 WKEENGRWSQIAVHA---VHSASVNSVQWAP-HEYGPLLLVASSDGKVSVVEFKENGTTS 137 + N + + P + S GK+ + + + + Sbjct: 160 FDVVNFDMINMLKLGYFPGQCEWIYC----PGDAISSVAASEKSTGKIFIYDGRGDNQPL 215 Query: 138 PIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI-----WKYNSDAQ 192 I H + P G + K W+Y +D Sbjct: 216 HIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYW---TGPPHEYKFPKNVNWEYKTDTD 272 Query: 193 TYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 Y + V +SP +A++ DR I+ Sbjct: 273 LYEFAKC----KAYPTSVCFSPD---GKKIATIGSDRKVRIFR 308 Score = 47.5 bits (111), Expect = 8e-06, Method: Composition-based stats. Identities = 29/199 (14%), Positives = 64/199 (32%), Gaps = 12/199 (6%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEG---ETHKLIDTLTGHEGPVWRVDWAH 63 +H +I + G + DK +K+F+V + G ++ Sbjct: 131 SHLGVIESIAVSSEGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYC---PG 187 Query: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 ++ AS GK+ I+ +H++ + ++ P V SSD Sbjct: 188 DAISSVAASEKSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNP----VYKAVVSSDK 243 Query: 124 KVSV--VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 + + P ++ + + +K T G+D Sbjct: 244 SGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRK 303 Query: 182 VKIWKYNSDAQTYVLESTL 200 V+I+++ + V + +L Sbjct: 304 VRIFRFVTGKLMRVFDESL 322 >5WLC-SG nrPDB Length = 573 Score = 66.0 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 37/298 (12%), Positives = 81/298 (27%), Gaps = 51/298 (17%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 H + I GK + T D+ + ++ E + + G V + + Sbjct: 233 EGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAF-RKN 291 Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 + ASC+ D K+ + ++SQ+ + H V + + V + D Sbjct: 292 SDQLYASCA-DFKIRTYSI--NQFSQLEILYGHHDIVEDISAL--AMERCVTVGARDRTA 346 Query: 126 SVVEFKENGT------------TSPIIIDAHAIGVNSASWAPATI-------EEDGEHNG 166 + + + + + G + P E + Sbjct: 347 MLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVS 406 Query: 167 TKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYL--AS 224 + F+TG + + +W + + +L S Sbjct: 407 MVDDFHFITGSDNGNICLWSLAK--------------KKPIFTERIAHGILPEPSFNDIS 452 Query: 225 VSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 D + + L + + L+ +S NV + +WK Sbjct: 453 GETDEELR-------KRQLQGKKLLQPFWITSLYAIPYS---NVFISGSWSGSLKVWK 500 Score = 46.0 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 20/95 (21%), Positives = 40/95 (42%), Gaps = 6/95 (6%) Query: 190 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLK 249 + E+T EGH D + VA SP Y+ + +DR I+W+ ++ ++ Sbjct: 222 PTSKHEYENTTEGHYDEILTVAASPD---GKYVVTGGRDRKLIVWSTESLSPV---KVIP 275 Query: 250 EEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 + + ++ + + L S D K+ + N Sbjct: 276 TKDRRGEVLSLAFRKNSDQLYASCADFKIRTYSIN 310 >4J0X-A nrPDB Length = 451 Score = 66.0 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 37/298 (12%), Positives = 81/298 (27%), Gaps = 51/298 (17%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 H + I GK + T D+ + ++ E + + G V + + Sbjct: 111 EGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAF-RKN 169 Query: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 + ASC+ D K+ + ++SQ+ + H V + + V + D Sbjct: 170 SDQLYASCA-DFKIRTYSI--NQFSQLEILYGHHDIVEDISAL--AMERCVTVGARDRTA 224 Query: 126 SVVEFKENGT------------TSPIIIDAHAIGVNSASWAPATI-------EEDGEHNG 166 + + + + + G + P E + Sbjct: 225 MLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVS 284 Query: 167 TKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYL--AS 224 + F+TG + + +W + + +L S Sbjct: 285 MVDDFHFITGSDNGNICLWSLAK--------------KKPIFTERIAHGILPEPSFNDIS 330 Query: 225 VSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 D + + L + + L+ +S NV + +WK Sbjct: 331 GETDEELR-------KRQLQGKKLLQPFWITSLYAIPYS---NVFISGSWSGSLKVWK 378 Score = 45.6 bits (106), Expect = 2e-05, Method: Composition-based stats. Identities = 20/95 (21%), Positives = 40/95 (42%), Gaps = 6/95 (6%) Query: 190 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLK 249 + E+T EGH D + VA SP Y+ + +DR I+W+ ++ ++ Sbjct: 100 PTSKHEYENTTEGHYDEILTVAASPD---GKYVVTGGRDRKLIVWSTESLSPV---KVIP 153 Query: 250 EEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 + + ++ + + L S D K+ + N Sbjct: 154 TKDRRGEVLSLAFRKNSDQLYASCADFKIRTYSIN 188 >5AMS-A nrPDB Length = 431 Score = 65.6 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 40/288 (13%), Positives = 93/288 (32%), Gaps = 25/288 (8%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 H + + + T D ++ + K TLTG+ V + G Sbjct: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTS--EG 121 Query: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYG--PLLLVASSDGKV 125 L + GKVL+ + A V + W ++DG V Sbjct: 122 GFLVTADMSGKVLV--HMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSV 179 Query: 126 SVVEFKENGTTSPIIIDA--HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 + E + ++ H + + + + + + VT D+ + Sbjct: 180 WCYQINEQDGSLEQLMSGFVHQQDCSMGEFI--------NTDKGENTLELVTCSLDSTIV 231 Query: 184 IWKYNSDAQTYVL-ESTLEGHSDWVRDVAWSPTVLLR---SYLASVSQDRTCIIWTQDNE 239 W + Q + + ++ ++G ++ +P L + +A S + + +N Sbjct: 232 AWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNG 291 Query: 240 QGPWKKTLLKE-----EKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 + + E ++ + SWS +++A+ ++ L+ Sbjct: 292 GAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYD 339 Score = 41.0 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 40/238 (16%), Positives = 71/238 (29%), Gaps = 21/238 (8%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW-- 61 + E + G L T +D + K+ G+ L V + W Sbjct: 104 TLTGYGESVISCSFTSEGGFLVT--ADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLK 161 Query: 62 AHPKFGTILASCSYDGKVLIW----KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPL-- 115 HP A + DG V W E++G Q+ VH + ++ + G Sbjct: 162 THPTIARTFAFGATDGSV--WCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTL 219 Query: 116 -LLVASSDGKVSVVEFKENGTTSPII---IDAHAIGVNSASWAPATIEE--DGEHNGTKE 169 L+ S D + I I S S AP T+ + G Sbjct: 220 ELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSN 279 Query: 170 SRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQ 227 + +N I ++ + + L+ + ++WS L + + Sbjct: 280 NGLLAVINCNNGGAILHLSTVIELKPEQDELDA---SIESISWSSKFSLMAIGLVCGE 334 Score = 30.6 bits (67), Expect = 0.88, Method: Composition-based stats. Identities = 8/31 (25%), Positives = 14/31 (45%) Query: 251 EKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 +K D ++ + ++ GGDN LW Sbjct: 62 DKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW 92 >3I2N-A nrPDB Length = 357 Score = 62.5 bits (150), Expect = 2e-10, Method: Composition-based stats. Identities = 41/299 (13%), Positives = 83/299 (27%), Gaps = 44/299 (14%) Query: 10 ELIHDAVL---DYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 + I + LAT + I+ +E + ++ GH+ + +D Sbjct: 66 KPIKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEMPVY-SVKGHKEIINAIDGIGGLG 124 Query: 67 GTI----LASCSYDGKVLIWK---EENGRWSQIAVHAVHSASVNSVQWAP--HEYGPLLL 117 + + S DG V +W +++ + V + +V + ++ ++ Sbjct: 125 IGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVC 184 Query: 118 VASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGG 177 +G + + + + I GV S + I + K V Sbjct: 185 AGYDNGDIKLFDLRNMALRWETNI---KNGVCSLEFDRKDISMN----------KLVATS 231 Query: 178 ADNLVKIWKYNSDAQTYVLESTLE-GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ 236 + ++ + T S E H V V P R + +W Sbjct: 232 LEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQN--RELFLTAGGAGGLHLWKY 289 Query: 237 DNEQGPWKK--------------TLLKEEKFPDVLWRASWSLSG-NVLALSGGDNKVTL 280 + KK L + WS + S D V + Sbjct: 290 EYPIQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRV 348 Score = 52.1 bits (123), Expect = 3e-07, Method: Composition-based stats. Identities = 40/259 (15%), Positives = 79/259 (30%), Gaps = 47/259 (18%) Query: 5 ANAHNELIHDAVLDYYGKR------LATCSSDKTIKIFE---VEGETHKLIDTLTGHEGP 55 H E+I+ + T S D T+K+++ + + ++ Sbjct: 107 VKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRD 166 Query: 56 VWRVDWAH--PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQW-APHEY 112 W V + + + ++ + +G + ++ N + V S+++ Sbjct: 167 CWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRN---MALRWETNIKNGVCSLEFDRKDIS 223 Query: 113 GPLLLVASSDGKVSVVEFKENGTTSPIII---DAHAIGVNSASWAPATIEEDGEHNGTKE 169 L+ S +GK V + + T AH V P E Sbjct: 224 MNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNREL--------- 274 Query: 170 SRKFVTGGADNLVKIWKYNSDAQTYVLEST------------LEGH---SDWVRDVAWSP 214 F+T G + +WKY Q +S L+ + + + WSP Sbjct: 275 ---FLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSP 331 Query: 215 TVLLRSYLASVSQDRTCII 233 S D+T + Sbjct: 332 DKRG--LCVCSSFDQTVRV 348 Score = 46.3 bits (108), Expect = 1e-05, Method: Composition-based stats. Identities = 26/205 (12%), Positives = 69/205 (33%), Gaps = 24/205 (11%) Query: 96 AVHSASVNSVQWAP--HEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASW 153 + +V +W P ++ + A G + + E ++G + A + ++ Sbjct: 15 KGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEI-QHGDLKLLREIEKAKPIKCGTF 73 Query: 154 APATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWS 213 + + R TG + IW + + +++GH + + + Sbjct: 74 ----------GATSLQQRYLATGDFGGNLHIWNLEAPE---MPVYSVKGHKEIINAIDGI 120 Query: 214 PTVLL---RSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASW----SLSG 266 + + + + S+D T +W + P + + W ++ + Sbjct: 121 GGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEE 180 Query: 267 NVLALSGGDNKVTLWKE-NLEGKWE 290 V+ + + L+ N+ +WE Sbjct: 181 RVVCAGYDNGDIKLFDLRNMALRWE 205 >1PI6-A nrPDB Length = 615 Score = 61.8 bits (148), Expect = 4e-10, Method: Composition-based stats. Identities = 46/244 (18%), Positives = 84/244 (34%), Gaps = 28/244 (11%) Query: 49 LTGHEGPV-WRVDWAHPKFGTILASCSYDGKVLIW----KEENG--RWSQIAVHAVHSAS 101 TGH V V ++ K L S GKV++W +E+ + + V + Sbjct: 59 FTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGP 118 Query: 102 VNSVQWAPHEYGPLLLVASSDG-KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEE 160 ++ + W G L V V ++G + + H+ +N+ Sbjct: 119 ISDISW--DFEGRRLCVVGEGRDNFGVFISWDSGNSLGE-VSGHSQRINA---------- 165 Query: 161 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRS 220 H + +T G D V ++ + + T +VRDV +SP Sbjct: 166 --CHLKQSRPMRSMTVGDDGSVVFYQ-GPPFKFSASDRTHHKQGSFVRDVEFSPD--SGE 220 Query: 221 YLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTL 280 ++ +V DR + + + K +E ++ SW L A G D + + Sbjct: 221 FVITVGSDRKISCFDGKSGEF-LKYIEDDQEPVQGGIFALSW-LDSQKFATVGADATIRV 278 Query: 281 WKEN 284 W Sbjct: 279 WDVT 282 Score = 56.4 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 49/272 (18%), Positives = 95/272 (34%), Gaps = 29/272 (10%) Query: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 ++ AT +D TI++++V TL + +V G I+ S S DG + Sbjct: 264 SQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRII-SLSLDGTLN 322 Query: 81 IWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII 140 ++ + + + H+ + ++ P L+ S DG++ + Sbjct: 323 FYELGHDEVLK--TISGHNKGITALTVNP------LISGSYDGRIMEWSSSSMHQDHSNL 374 Query: 141 I----DAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVL 196 I ++ A +S SW + K + D + + D + Sbjct: 375 IVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLL---I 431 Query: 197 ESTLEGHSDWVRDVAW-SPT---VLLRSYLASV-SQDRTCIIWTQ-DNEQGPWKKTLLKE 250 + G D ++ V SP L ++Y+A + T ++ D E KT L+ Sbjct: 432 LQSFTG--DIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRA 489 Query: 251 EKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 + S S S +A K+ L+ Sbjct: 490 KP-----SYISISPSETYIAAGDVMGKILLYD 516 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 21/123 (17%), Positives = 37/123 (30%), Gaps = 5/123 (4%) Query: 155 PATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGH-SDWVRDVAWS 213 P+T H + + + + GH S V V +S Sbjct: 14 PSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFS 73 Query: 214 PTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKF---PDVLWRASWSLSGNVLA 270 P + YL S + I+W ++ + + +F + SW G L Sbjct: 74 P-IKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLC 132 Query: 271 LSG 273 + G Sbjct: 133 VVG 135 Score = 27.1 bits (58), Expect = 8.9, Method: Composition-based stats. Identities = 8/38 (21%), Positives = 19/38 (50%), Gaps = 1/38 (2%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEV 38 ++ NAH + +++ + + L + +D IK + V Sbjct: 576 IIKALNAHKDGVNNLLWETPST-LVSSGADACIKRWNV 612 >5A9Q-0 nrPDB Length = 380 Score = 61.4 bits (147), Expect = 5e-10, Method: Composition-based stats. Identities = 40/184 (21%), Positives = 70/184 (38%), Gaps = 9/184 (4%) Query: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE--GETHKLIDTLTGHEGPVWRVD 60 I NA + +H + L S +KI++ G I +LTG P+ VD Sbjct: 166 TIDNADSSTLHAVTFLRTPEILTVNSI-GQLKIWDFRQQGNEPSQILSLTGDRVPLHCVD 224 Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 HP ++A+ DG + IW G +++ H A + V + P L S Sbjct: 225 -RHPNQQHVVATGGQDGMLSIWDVRQGTM-PVSLLKAHEAEMWEVHFHPSNPEHLF-TCS 281 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 DG + + + + H G S+++ +I + + S T A + Sbjct: 282 EDGSLWHWDASTDVPEKSSLF--HQGG-RSSTFLSHSISNQANVHQSVISSWLSTDPAKD 338 Query: 181 LVKI 184 ++I Sbjct: 339 RIEI 342 Score = 46.0 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 27/176 (15%), Positives = 51/176 (28%), Gaps = 22/176 (12%) Query: 112 YGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESR 171 P ++ DG++++ H V + A ++ T E Sbjct: 140 NNPEIVTVGEDGRINLFRAD------------HKEAVRTIDNADSSTLHAVTFLRTPE-- 185 Query: 172 KFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTC 231 +T + +KIW + +L G + V P + +A+ QD Sbjct: 186 -ILTVNSIGQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPN--QQHVVATGGQDGML 242 Query: 232 IIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSG-NVLALSGGDNKVTLWKENLE 286 IW P + +W + S L D + W + + Sbjct: 243 SIWDVRQGTMPVSLL----KAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTD 294 Score = 31.7 bits (70), Expect = 0.37, Method: Composition-based stats. Identities = 10/54 (18%), Positives = 21/54 (38%), Gaps = 3/54 (5%) Query: 2 VVIANAHNELIHDAVLDYYG-KRLATCSSDKTIKIFEVEGETHKLIDTLTGHEG 54 V + AH + + + L TCS D ++ ++ + + H+G Sbjct: 254 VSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLF--HQG 305 >5WLC-LN nrPDB Length = 776 Score = 60.6 bits (145), Expect = 7e-10, Method: Composition-based stats. Identities = 45/290 (15%), Positives = 97/290 (33%), Gaps = 31/290 (10%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 + +A +H I+ L RLA S+ I+I+ + + G + + + Sbjct: 46 ITSLAFSHKSNIN--KLTPSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLC 103 Query: 61 WAHPKFGTI-LASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA 119 W++ ++ L S V W G + + +S + S+ ++ L V Sbjct: 104 WSNVNGESLRLFSIGGSTVVTEWDLATG--LPLRNYDCNSGVIWSISI--NDSQDKLSVG 159 Query: 120 SSDGKVSVVEFKENGTTSPI--IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGG 177 +G V +++ I+ V + +W K+ + G Sbjct: 160 CDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAW--------------KKDDFVIGGC 205 Query: 178 ADNLVKIWKYNSDAQT-YVLESTLE-GHSDWVRDVAWSPTVLLRS-YLASVSQDRTCIIW 234 +D ++IW + + L T++ + + WS L R+ +AS + W Sbjct: 206 SDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFW 265 Query: 235 TQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 + + + N + +G D K+ + +N Sbjct: 266 DFQFATLNQSF-----KAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQN 310 Score = 33.6 bits (75), Expect = 0.093, Method: Composition-based stats. Identities = 31/238 (13%), Positives = 61/238 (25%), Gaps = 44/238 (18%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTG------HEGPVWRV 59 AH+ + D + + D+ I F + + H + + Sbjct: 277 KAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAI 336 Query: 60 DWAHPKFGTILASCSYDGKVLIWKEE---NGRWSQIAVHAVHSASV-------NSVQWA- 108 K L S + ++I NG + ++ +S +V V W+ Sbjct: 337 CAYQSKGADFLVSGGVEKTLVINSLTSFSNGNYRKMPTVEPYSKNVLVNKEQRLVVSWSE 396 Query: 109 --------------------------PHEYGPLLLVASSDGKVSVVEFKENGTTSPIIID 142 + S DG+V VV + Sbjct: 397 STVKIWTMGTDSSTEQNYKLVCKLTLKDDQNISTCSLSPDGQVLVVGRPSTTKVFHLQPV 456 Query: 143 AHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTL 200 + + V + + ++ K V ++ V I S+ E L Sbjct: 457 GNKLKVTKLD-NDLLLRTSTKLVKFIDNSKIVICSCEDDVFIVDLESEEDEKPQEVEL 513 >5K19-A nrPDB Length = 569 Score = 59.4 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 32/183 (17%), Positives = 66/183 (36%), Gaps = 15/183 (8%) Query: 9 NELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGT 68 +++ GK LA S D +++F ++ +L T+ + G + V W+ G Sbjct: 220 EGALNEFAFSPDGKFLACVSQDGFLRVFNF--DSVELHGTMKSYFGGLLCVCWSPD--GK 275 Query: 69 ILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 + + D V +W + IA H + V+ V + P+ + +G Sbjct: 276 YIVTGGEDDLVTVWSFVD--CRVIARGHGHKSWVSVVAFDPYT------TSVEEGDPM-- 325 Query: 129 EFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN 188 EF + ++ NS + + + + +F + G D + +W Sbjct: 326 EFSGSDEDFQDLLHFGRDRANSTQ-SRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLT 384 Query: 189 SDA 191 D Sbjct: 385 EDI 387 Score = 56.7 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 37/202 (18%), Positives = 66/202 (32%), Gaps = 31/202 (15%) Query: 90 SQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVN 149 + + V ++N ++P G L S DG + V F + ++ G+ Sbjct: 211 NPLLKWTVGEGALNEFAFSPD--GKFLACVSQDGFLRVFNFD--SVELHGTMKSYFGGLL 266 Query: 150 SASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRD 209 W+P + + VTGG D+LV +W + + + GH WV Sbjct: 267 CVCWSP-------------DGKYIVTGGEDDLVTVWSFVD----CRVIARGHGHKSWVSV 309 Query: 210 VAWSPT----VLLRSYLASVSQ-DRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSL 264 VA+ P S S D ++ + + L K ++ Sbjct: 310 VAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRF 369 Query: 265 SGNVLALSGGDNKVTLWKENLE 286 G D ++ LW + Sbjct: 370 -----GSVGQDTQLCLWDLTED 386 Score = 56.0 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 35/183 (19%), Positives = 57/183 (31%), Gaps = 42/183 (22%) Query: 99 SASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATI 158 + V V+W P L LVA S G + + + + AP Sbjct: 149 KSRVTCVKWVP-GSESLFLVAHSSGNMYLYNVEHT----------------CGTTAPHYQ 191 Query: 159 EEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLL 218 + + K + N + W A + A+SP Sbjct: 192 LLKQGESFAVHTCK--SKSTRNPLLKWTVGEGAL---------------NEFAFSPD--- 231 Query: 219 RSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKV 278 +LA VSQD ++ D+ + + + L WS G + G D+ V Sbjct: 232 GKFLACVSQDGFLRVFNFDSVE-----LHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 286 Query: 279 TLW 281 T+W Sbjct: 287 TVW 289 >5M89-A nrPDB Length = 329 Score = 58.7 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 40/263 (15%), Positives = 78/263 (29%), Gaps = 39/263 (14%) Query: 19 YYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGK 78 + G ++ ++ +K+++ + T H GPV + HP G ILAS D Sbjct: 100 WTGTKVVIGTAKGWVKVYD----AGRESATFQTHAGPVTGLA-VHPG-GRILASVGVDKS 153 Query: 79 VLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSP 138 + + E G A++ + + P G L + G + V Sbjct: 154 FVFYDLETGE---RVARGYADAALTTCAFHPD--GNLFAAGTQTGHILVFHTTTLEQAES 208 Query: 139 IIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLES 198 P TG + V I+ ++ + Sbjct: 209 F---------------PLGTPIQALAFSENGFWFAATGKGTSSVTIFDLR---KSGAAAA 250 Query: 199 TLEGHSDWVRDVAWSPTVLLRSYLASVSQDR-TCIIWTQDNEQGPWKKTLLKEEKFPDVL 257 E + V ++W YLA+ T ++T K+ + + + Sbjct: 251 VKELQTGEVLSISWD---YTGQYLATGGGTGVTVQMYT------KATKSWSEPVRLGMPV 301 Query: 258 WRASWSLSGNVLALSGGDNKVTL 280 W L + + V++ Sbjct: 302 VGVKWGGEAKRLVVVSREGVVSV 324 Score = 46.0 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 40/284 (14%), Positives = 81/284 (28%), Gaps = 41/284 (14%) Query: 10 ELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTI 69 + + LD + A D + I+ V + + PV +W K + Sbjct: 52 NVTQASSLDLENECAAVGGLDGKLDIYSVVANKVERTLDI---GEPVTATEWTGTK---V 105 Query: 70 LASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVE 129 + G W + + A H+ V + P G +L D + Sbjct: 106 VI-----GTAKGWVKVYDAGRESATFQTHAGPVTGLAVHP--GGRILASVGVDKSFVFYD 158 Query: 130 FKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNS 189 + + DA ++ P + F G + ++ Sbjct: 159 LETGERVARGYADAALTTC---AFHP-------------DGNLFAAGTQTGHILVF---- 198 Query: 190 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLK 249 T + + ++ +A+S + A+ + I+ Sbjct: 199 HTTTLEQAESFPLGT-PIQALAFSENGFW--FAATGKGTSSVTIFDLRKSGAAA----AV 251 Query: 250 EEKFPDVLWRASWSLSGNVLALSGGDN-KVTLWKENLEGKWEPA 292 +E + SW +G LA GG V ++ + + EP Sbjct: 252 KELQTGEVLSISWDYTGQYLATGGGTGVTVQMYTKATKSWSEPV 295 Score = 44.4 bits (103), Expect = 6e-05, Method: Composition-based stats. Identities = 20/152 (13%), Positives = 57/152 (37%), Gaps = 10/152 (6%) Query: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 H + + G+ LA+ DK+ +++ ET + + + + + Sbjct: 124 ATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDL--ETGERVARGYA-DAALTTCAF- 179 Query: 63 HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD 122 HP G + A+ + G +L++ ++ + ++ ++ + + Sbjct: 180 HP-DGNLFAAGTQTGHILVFHTTTLEQAESFPLGT---PIQALAFSENGF-WFAATGKGT 234 Query: 123 GKVSVVEFKENGTTSPIIIDAHAIGVNSASWA 154 V++ + +++G + + + V S SW Sbjct: 235 SSVTIFDLRKSGAAAA-VKELQTGEVLSISWD 265 Score = 29.0 bits (63), Expect = 2.3, Method: Composition-based stats. Identities = 13/65 (20%), Positives = 23/65 (35%), Gaps = 4/65 (6%) Query: 9 NELIHDAVLDYYGKRLATCSSDK-TIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 + DY G+ LAT T++++ ++ L PV V W Sbjct: 256 TGEVLSISWDYTGQYLATGGGTGVTVQMYTKATKSWSEPVRL---GMPVVGVKWGGEAKR 312 Query: 68 TILAS 72 ++ S Sbjct: 313 LVVVS 317 >5OV3-A nrPDB Length = 381 Score = 58.3 bits (139), Expect = 4e-09, Method: Composition-based stats. Identities = 41/291 (14%), Positives = 88/291 (30%), Gaps = 27/291 (9%) Query: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 I +AH + G +L + S+D + ++V P+ +V + Sbjct: 62 IISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFP---SPILKVQYHP 118 Query: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 +L V++ S+ V V S +V + G + ++ G Sbjct: 119 RDQNKVLVCPMKSAPVML----TLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKG 174 Query: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 K+ V++ + + + ++ F+ AD +++ Sbjct: 175 KILVLKTDSQDLVASFRVTTGTSNTTAI----------KSIEFARKGSCFLINTADRIIR 224 Query: 184 IWKYNSDAQTYV--LESTLEGHSDWVRDVAW--SPTVLLRSYLASVSQ-DRTCIIWTQDN 238 ++ ++ D V W Y+ + S IW + Sbjct: 225 VYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIW--EK 282 Query: 239 EQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKW 289 G K L ++L +W ++A V++W +N W Sbjct: 283 SIGNLVKILHGTRG--ELLLDVAWHPVRPIIASISS-GVVSIWAQNQVENW 330 Score = 56.7 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 40/260 (15%), Positives = 83/260 (31%), Gaps = 43/260 (16%) Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 ++GT+LA DG+++IW ++I + H V S+ W+ G L+ AS+ Sbjct: 32 TFNRWGTLLAVGCNDGRIVIWDFLTRGIAKI--ISAHIHPVCSLCWS--RDGHKLVSAST 87 Query: 122 DGKVSVVEFKENGTTSPIIIDA-------HAIGVNSASWAP---------ATIEEDGEHN 165 D VS + + H N P + + Sbjct: 88 DNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLP 147 Query: 166 GTKESRKFVTGGADN----------LVKIWKYNSDAQTYVL---ESTLEGHSDWVRDVAW 212 +S V D KI +D+Q V +T ++ ++ + + Sbjct: 148 VDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEF 207 Query: 213 SPTVLLRSYLASVSQDRTCIIWTQD-----NEQGPWKKTLLKEEKFPDVLW-RASWSLSG 266 + S + DR ++ G + ++ W + +S G Sbjct: 208 A---RKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDG 264 Query: 267 NVLALSGGDN-KVTLWKENL 285 + + +W++++ Sbjct: 265 EYIVAGSARQHALYIWEKSI 284 Score = 34.8 bits (78), Expect = 0.048, Method: Composition-based stats. Identities = 30/192 (15%), Positives = 61/192 (31%), Gaps = 14/192 (7%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDT-----LTGHEGPV 56 V ++ I G ++D+ I++++ E + + V Sbjct: 192 VTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGR-EILTCGRDGEPEPMQKLQDLV 250 Query: 57 WRVDW---AHPKFGTILASCS-YDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEY 112 R W G + + S + IW++ G +I H + V W P Sbjct: 251 NRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKIL-HGTRGELLLDVAWHP--V 307 Query: 113 GPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRK 172 P++ SS G VS+ + S D + N + + + + ++ + Sbjct: 308 RPIIASISS-GVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPKQT 366 Query: 173 FVTGGADNLVKI 184 D V + Sbjct: 367 GADAAEDEEVDV 378 Score = 29.4 bits (64), Expect = 1.8, Method: Composition-based stats. Identities = 5/24 (20%), Positives = 13/24 (54%) Query: 259 RASWSLSGNVLALSGGDNKVTLWK 282 +++ G +LA+ D ++ +W Sbjct: 30 TCTFNRWGTLLAVGCNDGRIVIWD 53 >6CHG-D nrPDB Length = 439 Score = 58.3 bits (139), Expect = 4e-09, Method: Composition-based stats. Identities = 44/258 (17%), Positives = 81/258 (31%), Gaps = 23/258 (8%) Query: 44 KLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIA--VHAVHSAS 101 KL TL PV V G LA +G ++I+ ++ + + H+ S Sbjct: 19 KLTHTLE---VPVAAVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRS 75 Query: 102 VNSVQWAPHEYGPLLLVASSDGKVSVVEFKE-NGTTSPIIIDAHAIGVNSASWAPATIEE 160 V SV W+ G L + D + + + D + W + Sbjct: 76 VQSVCWSND--GRYLWSSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWNVCIVTV 133 Query: 161 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRS 220 E +V D + + + GH + P + S Sbjct: 134 VEEPTA------YVLTLTDRQNAFHCFP----LLEQDQDISGHG---YTLVACPHPTIES 180 Query: 221 YLASVSQDRTCIIWTQDNEQGPWKK--TLLKEEKFPDVLWRASWSLSGNVLALSGGDNKV 278 + + + + D E G K +E+ + + S SG +A++G D + Sbjct: 181 IIITGTSKGWINAFQLDLESGFEDKIRCCYEEKIANANIKQIIISPSGTRIAINGSDRTI 240 Query: 279 TLWKENLEGKWEPAGEVH 296 ++ +E G H Sbjct: 241 RQYQLIVEDNESEGGSSH 258 Score = 56.4 bits (134), Expect = 1e-08, Method: Composition-based stats. Identities = 42/291 (14%), Positives = 91/291 (31%), Gaps = 38/291 (13%) Query: 14 DAVLDYYGKRLATCSSDKTIKIFEVEGET-HKLIDTLTG-HEGPVWRVDWAHPKFGTILA 71 G LA S+ I I++++ ++ T +G H V V W++ G L Sbjct: 32 CVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSND--GRYLW 89 Query: 72 SCSYDGKVLIWKEENG-RWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEF 130 S D +W + Q S + V+W ++ + V+ Sbjct: 90 SSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWN-----VCIVTVVEEPTAYVLTL 144 Query: 131 KENGTTS-PIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNS 189 + + ++ +TG + + ++ + Sbjct: 145 TDRQNAFHCFPLLEQDQDISG------HGYTLVACPHPTIESIIITGTSKGWINAFQLDL 198 Query: 190 DA---QTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKK- 245 ++ + + ++ + SP+ + +A DRT + E + Sbjct: 199 ESGFEDKIRCCYEEKIANANIKQIIISPS---GTRIAINGSDRTIRQYQLIVEDNESEGG 255 Query: 246 -----TLLKEEKFPDVLWRASWSL------SGNVL---ALSGGDNKVTLWK 282 ++ E K+ D++ R W+ SG L A + + LW+ Sbjct: 256 SSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWE 306 Score = 45.6 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 38/306 (12%), Positives = 96/306 (31%), Gaps = 43/306 (14%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 AH + G+ L + D K++++ T K +GP+W ++ Sbjct: 71 AHTRSVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPT-KCFQQYK-FDGPLWSCHVV--RW 126 Query: 67 GTILASCSYDGKVLIWKEENGR--------WSQIAVHAVHSASVNSVQWAPHEY-GPLLL 117 + + + + + + Q + H ++ + PH +++ Sbjct: 127 NVCIVTVVEEPTAYVLTLTDRQNAFHCFPLLEQDQDISGHGYTLVAC---PHPTIESIII 183 Query: 118 VASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGG 177 +S G ++ + + + + + + G Sbjct: 184 TGTSKGWINAFQLD--------LESGFEDKIRCCYEEKIANANIKQIIISPSGTRIAING 235 Query: 178 ADNLVKIWKY------NSDAQTYVLESTLEG-HSDWVRDVAWSP---TVLLRSYLAS--- 224 +D ++ ++ + ++ + LE + D + + W+ + YL + Sbjct: 236 SDRTIRQYQLIVEDNESEGGSSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAH 295 Query: 225 VSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGD-NKVTLWKE 283 S +W + G + L E + L W+ +A +G + V +W Sbjct: 296 GSSAHDLYLW--ETSSGSLVRVL---EGADEELLDIDWNFYSMRIASNGFESGWVYMWSI 350 Query: 284 NLEGKW 289 + KW Sbjct: 351 VIPPKW 356 >3DW8-B nrPDB Length = 447 Score = 58.3 bits (139), Expect = 4e-09, Method: Composition-based stats. Identities = 51/358 (14%), Positives = 103/358 (28%), Gaps = 97/358 (27%) Query: 10 ELIHDAVLDYYGKRLATCSSDKTIKIFEVEGET---------HKLIDTLTGHEGP----- 55 ++I ++ G+ LAT + IF+ E E + + T HE Sbjct: 29 DIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLK 88 Query: 56 -------VWRVDWAHPKFGTILASCSYDGKVLIW--------------KEENGRWSQIAV 94 + ++ W K + D + +W KEE+GR+ Sbjct: 89 SLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTT 148 Query: 95 HAV------------------------HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEF 130 H+ +NS+ L D ++++ Sbjct: 149 VTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSA---DDLRINLWHL 205 Query: 131 KENGTTSPII------IDAHAIGVNSASWAPATIEEDGEHNGTKESRKF---VTGGADNL 181 + + I+ ++ + +A + P + + R + D Sbjct: 206 EITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRH 265 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVL---LRSYLASVSQDRTCIIWTQDN 238 K+++ D S + + DV +S + R YL + +W + Sbjct: 266 SKLFEEPEDPSNRSFFSEI---ISSISDVKFSHSGRYMMTRDYL-------SVKVWDLNM 315 Query: 239 EQGPWKKTLLKEEKFPDVLWR------------ASWSLSGNVLALSGGDNKVTLWKEN 284 E P + T E L W+ S +V+ +N ++ N Sbjct: 316 ENRPVE-TYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRN 372 >5WLC-LS nrPDB Length = 594 Score = 54.8 bits (130), Expect = 4e-08, Method: Composition-based stats. Identities = 48/350 (13%), Positives = 100/350 (28%), Gaps = 76/350 (21%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 +H+ I L T DKT++I+ ++G+T+ L+ +L P+ + Sbjct: 247 SHS-AIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLS 305 Query: 67 GTI---LASCSYDGKVLIWKE--------------------------------------- 84 + + + W Sbjct: 306 NQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSFENFKVAHLQN 365 Query: 85 -ENGRWSQIAVHAVHSASVN----------------------SVQWAPHEYGPL---LLV 118 + I + ++ +N + + P G L+ Sbjct: 366 SQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQPISRGKFRTILIA 425 Query: 119 ASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTK--ESRKFVTG 176 ++ G+V + +NG D +G+ T +K ++R G Sbjct: 426 VNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVG 485 Query: 177 GADNLVKIWKYNSD--AQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 V ++ N+ + T + L+ + + ++ +SP L S+ + Sbjct: 486 SESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPD---GQILCMASRAVKDALR 542 Query: 235 TQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKEN 284 + ++S SG +LA+ KV LWK N Sbjct: 543 LVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLN 592 Score = 29.4 bits (64), Expect = 1.9, Method: Composition-based stats. Identities = 3/29 (10%), Positives = 11/29 (37%) Query: 12 IHDAVLDYYGKRLATCSSDKTIKIFEVEG 40 + G LA + ++++++ Sbjct: 565 VTSVAFSPSGGLLAVGNEQGKVRLWKLNH 593 Score = 27.5 bits (59), Expect = 7.6, Method: Composition-based stats. Identities = 17/89 (19%), Positives = 29/89 (32%), Gaps = 5/89 (5%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGP---VWR 58 V + I + G+ L S + V + + P V Sbjct: 508 VAALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGKVTS 567 Query: 59 VDWAHPKFGTILASCSYDGKVLIWKEENG 87 V ++ G +LA + GKV +WK + Sbjct: 568 VAFSP--SGGLLAVGNEQGKVRLWKLNHY 594 >5MC6-j nrPDB Length = 397 Score = 53.3 bits (126), Expect = 1e-07, Method: Composition-based stats. Identities = 52/312 (16%), Positives = 104/312 (33%), Gaps = 40/312 (12%) Query: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEV-----EGETHKLIDTL---TG-HEGPV 56 AH+ I +CS D +K+++ E K +G H V Sbjct: 13 KAHDADIFSVS--ACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDV 70 Query: 57 WRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHS--------ASVNSVQWA 108 + ++A+ S+ G +L ++ ++ + S +++W Sbjct: 71 LQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKWG 130 Query: 109 PHEYGPL---LLVASSDGKVSVVEFK--ENGTTSPIIIDAHAIGVNSASWAPATIEEDGE 163 L L+ G + +F + + S + + + + +P T + Sbjct: 131 ASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFAT 190 Query: 164 HNGTKESRKFVTGGADNLVKIWKYN--SDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSY 221 E TG + V+I + + + + ++ +S+ +R V +SP S Sbjct: 191 SVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQ---GSL 247 Query: 222 LASVSQDRTC-IIWTQDNEQGPWKKTL----------LKEEKFPDVLWRASWSLSGNVLA 270 LA + I + E G +L L E + S++ SG L Sbjct: 248 LAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLC 307 Query: 271 LSGGDNKVTLWK 282 +G D K+ W Sbjct: 308 SAGWDGKLRFWD 319 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 22/123 (17%), Positives = 34/123 (27%), Gaps = 16/123 (13%) Query: 9 NELIHDAVLDYYGKRLATCSSDK---TIKIFE---------VEGETHKLIDTL--TGHEG 54 + I G LA I ++E + TH +L H Sbjct: 233 SNSIRSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSS 292 Query: 55 PVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGP 114 V + + G L S +DGK+ W + + A E+G Sbjct: 293 WVMSLSFN--DSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDIEIEEDILAVDEHGD 350 Query: 115 LLL 117 L Sbjct: 351 SLA 353 Score = 39.0 bits (89), Expect = 0.002, Method: Composition-based stats. Identities = 25/133 (18%), Positives = 52/133 (39%), Gaps = 24/133 (18%) Query: 23 RLATCSSDKTIKIFEVEGE----THKLIDTLTGHEGPVWRVDWAHPKFGTILA----SCS 74 +AT ++ T++I E+ + ++ + + V ++ G++LA S S Sbjct: 199 LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSP--QGSLLAIAHDSNS 256 Query: 75 YDGKVLIWKEENGR-----------WSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 + G + +++ E G HS+ V S+ + ++ G L A DG Sbjct: 257 F-GCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSF--NDSGETLCSAGWDG 313 Query: 124 KVSVVEFKENGTT 136 K+ + K Sbjct: 314 KLRFWDVKTKERI 326 Score = 36.7 bits (83), Expect = 0.013, Method: Composition-based stats. Identities = 16/139 (11%), Positives = 37/139 (26%), Gaps = 8/139 (5%) Query: 115 LLLVASSDGKVSVVEFKENGTTSPIIIDA----HAIGVNSASWAPATIEEDGEHNGTKES 170 L+ ++G V + E ++ + S ++P H+ Sbjct: 199 LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLAIAHDSNSFG 258 Query: 171 RKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT 230 + + +I + + HS WV +++ L S D Sbjct: 259 CITLY-ETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSF---NDSGETLCSAGWDGK 314 Query: 231 CIIWTQDNEQGPWKKTLLK 249 W ++ + Sbjct: 315 LRFWDVKTKERITTLNMHC 333 Score = 34.0 bits (76), Expect = 0.086, Method: Composition-based stats. Identities = 11/50 (22%), Positives = 23/50 (46%), Gaps = 2/50 (4%) Query: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPV 56 AH+ + + G+ L + D ++ ++V+ T + I TL H + Sbjct: 289 AHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVK--TKERITTLNMHCDDI 336 >2I3T-A nrPDB Length = 341 Score = 52.5 bits (124), Expect = 2e-07, Method: Composition-based stats. Identities = 47/294 (15%), Positives = 95/294 (32%), Gaps = 31/294 (10%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDK--TIKIFEVEGETHKLIDTLT-GHEGPVW 57 +V I A + I D + L S D T+ F+++ + L+ +L H P+ Sbjct: 3 IVQIEQAPKDYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLRYKH--PLL 60 Query: 58 RVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLL 117 ++ + + G++L Q + + + + L+ Sbjct: 61 CCNFI-DNTDLQIYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRIC---KYGDDKLI 116 Query: 118 VASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGG 177 AS DG + V++ + G I V + + + T ++ S + + G Sbjct: 117 AASWDGLIEVIDPRNYG--------DGVIAVKNLN-SNNTKVKNKIFTMDTNSSRLIVGM 167 Query: 178 ADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII--WT 235 ++ V+ W + G +RDVA P A S D + + Sbjct: 168 NNSQVQ-WFRLPLCEDDNGTIEESGLKYQIRDVALLPKEQEG--YACSSIDGRVAVEFFD 224 Query: 236 QDNEQ--------GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 + + LK+ + +S L +G D ++ W Sbjct: 225 DQGDDYNSSKRFAFRCHRLNLKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCW 278 >5TF2-A nrPDB Length = 407 Score = 49.4 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 18/85 (21%), Positives = 31/85 (36%), Gaps = 7/85 (8%) Query: 59 VDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 118 V + H T+LA+ DG V +WK + ++ H + + P L+ Sbjct: 178 VCFNHDN--TLLATGGTDGYVRVWKVPS--LEKVLEFKAHEGEIEDLALGPDGK---LVT 230 Query: 119 ASSDGKVSVVEFKENGTTSPIIIDA 143 D K SV + + T + Sbjct: 231 VGRDLKASVWQKDQLVTQLHWQENG 255 Score = 48.3 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 42/242 (17%), Positives = 73/242 (30%), Gaps = 44/242 (18%) Query: 15 AVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCS 74 ++ LAT +D +++++V + + + HEG + + L + Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKV--PSLEKVLEFKAHEGEIEDLALGPDGK---LVTVG 232 Query: 75 YDGKVLIWK----------EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 D K +W+ +ENG + + V P L V + Sbjct: 233 RDLKASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGL-RLFTVQIPHKR 291 Query: 125 VSVVE-----FKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGAD 179 + + P+ + V S D +GT VTG Sbjct: 292 LRQPPPCYLTAWDGSNFLPLRTKSCGHEVVS--------CLDVSESGTFLGLGTVTGSVA 343 Query: 180 NLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLA--------SVSQDRTC 231 + ++ YV E H V DVA+ P L SV+ D C Sbjct: 344 IYI---AFSLQCLYYV----REAHGIVVTDVAFLPEKGRGPELLGSHETALFSVAVDSRC 396 Query: 232 II 233 + Sbjct: 397 QL 398 Score = 44.4 bits (103), Expect = 5e-05, Method: Composition-based stats. Identities = 13/75 (17%), Positives = 30/75 (40%), Gaps = 9/75 (12%) Query: 210 VAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVL 269 V ++ L LA+ D +W P + +L+ + + + G ++ Sbjct: 178 VCFNHDNTL---LATGGTDGYVRVWKV-----PSLEKVLEFKAHEGEIEDLALGPDGKLV 229 Query: 270 ALSGGDNKVTLWKEN 284 G D K ++W+++ Sbjct: 230 -TVGRDLKASVWQKD 243 Score = 42.5 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 17/88 (19%), Positives = 31/88 (35%), Gaps = 8/88 (9%) Query: 150 SASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRD 209 + ++ ++ TGG D V++WK S + H + D Sbjct: 164 AVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPS----LEKVLEFKAHEGEIED 219 Query: 210 VAWSPTVLLRSYLASVSQDRTCIIWTQD 237 +A P L +V +D +W +D Sbjct: 220 LALGPDGK----LVTVGRDLKASVWQKD 243 >3EI3-B nrPDB Length = 383 Score = 48.7 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 36/294 (12%), Positives = 86/294 (29%), Gaps = 26/294 (8%) Query: 9 NELIHDAVLDY-YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 + + + +A S I +++ + + G + + + Sbjct: 73 DRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQFNTN 132 Query: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 + S L ++ +G Q+ ++A+ D + Sbjct: 133 QLFVSSIRGATTL--RDFSGSVIQVFAKTDSWDYWYCCV---DVSVSRQMLATGDSTGRL 187 Query: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 + +G H V A + P T D VK+W Sbjct: 188 LLLGLDGH-EIFKEKLHKAKVTHAEFNPRC------------DWLMATSSVDATVKLWDL 234 Query: 188 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTL 247 + + + H V ++PT + L + Q +++ + P + + Sbjct: 235 RNIKDKNSYIAEMP-HEKPVNAAYFNPTDSTK--LLTTDQRNEIRVYSSYDWSKPDQIII 291 Query: 248 LKEEKFPD-VLWRASWSLSGNVLALSGG-DNKVTLWKENLEGKWE--PAGEVHQ 297 +F +A+W +++ D+++ L + ++ G VHQ Sbjct: 292 HPHRQFQHLTPIKATWHPMYDLIVAGRYPDDQLLLNDKRTIDIYDANSGGLVHQ 345 Score = 47.5 bits (111), Expect = 7e-06, Method: Composition-based stats. Identities = 35/191 (18%), Positives = 68/191 (35%), Gaps = 17/191 (8%) Query: 52 HEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHA-VHSASVNSVQWAPH 110 H+ V ++ +P+ ++A+ S D V +W N + + H VN+ + P Sbjct: 203 HKAKVTHAEF-NPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPT 261 Query: 111 EYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVN----SASWAPATIEEDGEHNG 166 + LL + ++ V + III H + A+W P + + Sbjct: 262 DSTKLLTTDQRN-EIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKATWHP--MYDLIVAGR 318 Query: 167 TKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVS 226 + + + + I+ NS + L + +SPT LAS Sbjct: 319 YPDDQLLL--NDKRTIDIYDANSGGLVHQLRDPNAA--GIISLNKFSPT---GDVLAS-G 370 Query: 227 QDRTCIIWTQD 237 +IW ++ Sbjct: 371 MGFNILIWNRE 381 >4AV8-A nrPDB Length = 339 Score = 47.9 bits (112), Expect = 5e-06, Method: Composition-based stats. Identities = 34/159 (21%), Positives = 59/159 (37%), Gaps = 8/159 (5%) Query: 50 TGHEGPVWRVDWAHPKFGTILASCSYDGK-VLIWKEENGRWSQIAVHAVHSASVNSVQWA 108 H PV V + G ++A+CS DG + +++ +NG + + S+ ++W+ Sbjct: 176 KAHANPVKMVRLN--RKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWS 233 Query: 109 PHEYGPLLLVASSDGKVSVVE-FKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGT 167 P G L V S + V E F + ++ D I + W+ + Sbjct: 234 PD--GSKLAVVSDKWTLHVFEVFNDAENKRHVLKDWINIKYFQSEWSICNFKLKVSKGS- 290 Query: 168 KESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDW 206 K LV +W A T+ L + H W Sbjct: 291 -NDCKIAWISDTGLVIVWPNRRLADTFKLNYNDDEHVWW 328 Score = 32.5 bits (72), Expect = 0.26, Method: Composition-based stats. Identities = 16/88 (18%), Positives = 35/88 (39%), Gaps = 7/88 (7%) Query: 202 GHSDWVRDVAWSPTVLLRSYLASVSQDRT-CIIWTQDNEQGPWKKTLLKEEKFPDVLWRA 260 H++ V+ V +A+ SQD T ++ DN G + + ++ Sbjct: 177 AHANPVKMVRL---NRKGDMVATCSQDGTLIRVFQTDN--GVLVREFRRGLDRTSII-DM 230 Query: 261 SWSLSGNVLALSGGDNKVTLWKENLEGK 288 WS G+ LA+ + +++ + + Sbjct: 231 RWSPDGSKLAVVSDKWTLHVFEVFNDAE 258 >6CVZ-A nrPDB Length = 351 Score = 47.5 bits (111), Expect = 7e-06, Method: Composition-based stats. Identities = 39/252 (15%), Positives = 70/252 (27%), Gaps = 36/252 (14%) Query: 52 HEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHE 111 H + + ++ G +L S S D + + E Q V S W E Sbjct: 73 HGKQIRGLAFSSYLRG-LLLSASLDNTIKLTSLETNTVVQTYNAGR---PVWSCCWCLDE 128 Query: 112 YGPLLLVASSDGKVSVVEFKENGT-TSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKES 170 + ++G + V + + + ++ + S S+ P + G Sbjct: 129 A-NYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAASAAFPYGG---- 183 Query: 171 RKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDR- 229 V G W+ D + LE + + R L + D+ Sbjct: 184 ---VLAGTLEDASFWEQKMDFSHWPHVLPLE----PGGCIDFQTENSSRHCLVTYRPDKN 236 Query: 230 --TCI------IWTQDNEQGPWKKTLLKEEKFPDVLWRA--------SWSLSGNVLALSG 273 T + D+ P F + S GN+L +G Sbjct: 237 HTTIRSVLMEMSYRLDDTGNPICSCQPVHTFFGGPTCKLLTKNAIFQSPENDGNILVCTG 296 Query: 274 GD--NKVTLWKE 283 + N LW Sbjct: 297 DEAANSALLWDA 308 Score = 44.8 bits (104), Expect = 4e-05, Method: Composition-based stats. Identities = 32/201 (15%), Positives = 63/201 (31%), Gaps = 10/201 (4%) Query: 8 HNELIHDAVLDYYGK-RLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H + I Y + L + S D TIK+ +E T ++ T PVW W + Sbjct: 73 HGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNT--VVQTYNA-GRPVWSCCWCLDEA 129 Query: 67 GTILASCSYDGKVLIWKEEN-GRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS-SDGK 124 + + +G +L++ N Q V + S+ + P G Sbjct: 130 N-YIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAASAAFPYGGVLAGT 188 Query: 125 V---SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 + S E K + + P ++ G ++ + K + + Sbjct: 189 LEDASFWEQKMDFSHWPHVLPLEPGGCIDFQTENSSRHCLVTYRPDKNHTTIRSVLMEMS 248 Query: 182 VKIWKYNSDAQTYVLESTLEG 202 ++ + + T G Sbjct: 249 YRLDDTGNPICSCQPVHTFFG 269 >5WLC-LH nrPDB Length = 896 Score = 42.9 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 16/89 (17%), Positives = 33/89 (37%), Gaps = 5/89 (5%) Query: 9 NELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGT 68 + +D G++LA + I I + +L L H V + ++H G+ Sbjct: 256 TRYVSSMAIDNMGQQLAVGFASGVISIVSLADLQIRL---LKWHIDSVLSLSFSHD--GS 310 Query: 69 ILASCSYDGKVLIWKEENGRWSQIAVHAV 97 L S ++ + +W+ E + Sbjct: 311 YLLSGGWEKVMSLWQLETNSQQFLPRLNG 339 Score = 39.8 bits (91), Expect = 0.001, Method: Composition-based stats. Identities = 22/150 (14%), Positives = 51/150 (34%), Gaps = 7/150 (4%) Query: 148 VNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTL---EGHS 204 + + + + +++K W N + + L++ + G S Sbjct: 495 ITDLKFTKDGQWMITYEIEYPPNDLLSSKDLTHILKFWTKNDNETNWNLKTKVINPHGIS 554 Query: 205 DWVRDVAWSPTVLLRSYLA-SVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRAS-- 261 + + SP + S + + W+ D+ + W + F S Sbjct: 555 VPITKILPSPRSVNNSQGCLTADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSLA 614 Query: 262 WSLSGNVLALSGGDNKVTLWKENLEGKWEP 291 WS G+++ G D+K+ + + K+E Sbjct: 615 WSQDGSLIFH-GFDDKLQILDFDTFKKFES 643 Score = 36.3 bits (82), Expect = 0.015, Method: Composition-based stats. Identities = 7/50 (14%), Positives = 22/50 (44%) Query: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTG 51 + + H + + + G L + +K + ++++E + + + L G Sbjct: 290 IRLLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLETNSQQFLPRLNG 339 Score = 32.9 bits (73), Expect = 0.17, Method: Composition-based stats. Identities = 8/30 (26%), Positives = 15/30 (50%) Query: 253 FPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 D + S+S G+ L G + ++LW+ Sbjct: 296 HIDSVLSLSFSHDGSYLLSGGWEKVMSLWQ 325 Score = 32.9 bits (73), Expect = 0.18, Method: Composition-based stats. Identities = 10/47 (21%), Positives = 18/47 (38%), Gaps = 3/47 (6%) Query: 203 HSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLK 249 H D V +++S SYL S ++ +W + + L Sbjct: 296 HIDSVLSLSFSHD---GSYLLSGGWEKVMSLWQLETNSQQFLPRLNG 339 Score = 30.2 bits (66), Expect = 1.2, Method: Composition-based stats. Identities = 18/103 (17%), Positives = 42/103 (40%), Gaps = 18/103 (17%) Query: 90 SQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVN 149 SQ + ++ V+S+ G L V + G +S+V + ++ H V Sbjct: 247 SQTQSLSYNTRYVSSMAI--DNMGQQLAVGFASGVISIVSLAD---LQIRLLKWHIDSVL 301 Query: 150 SASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQ 192 S S++ + ++GG + ++ +W+ +++Q Sbjct: 302 SLSFS-------------HDGSYLLSGGWEKVMSLWQLETNSQ 331 >4FHN-A nrPDB Length = 394 Score = 42.5 bits (98), Expect = 2e-04, Method: Composition-based stats. Identities = 28/128 (21%), Positives = 50/128 (39%), Gaps = 12/128 (9%) Query: 20 YGKRLATCSSDKTIKIFEVEGETHKLIDTL---TGHEGPVWRVDWA------HPKFGTIL 70 Y LA D T+++ + ET L +GH V +D A + ++ Sbjct: 101 YSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVYSADNRLAEQVI 160 Query: 71 ASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEF 130 AS D ++IW+ + I S+ SVQ+ P L+ V +G + + ++ Sbjct: 161 ASVGDDCTLIIWRLTD--EGPILAGYPLSSPGISVQFRPSNPNQLI-VGERNGNIRIFDW 217 Query: 131 KENGTTSP 138 N + Sbjct: 218 TLNLSAEE 225 Score = 35.6 bits (80), Expect = 0.024, Method: Composition-based stats. Identities = 33/145 (22%), Positives = 52/145 (35%), Gaps = 15/145 (10%) Query: 161 DGEHNGTKESRKFVTGGA-DNLVK-IWKYNSDAQTYVLESTLEGHSDWVRDVAWSP---- 214 DG N + F+ DN V+ I N T + GH ++V D+ + Sbjct: 92 DGNVNSSPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVYSA 151 Query: 215 -TVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSG-NVLALS 272 L +ASV D T IIW ++GP +L + S N L + Sbjct: 152 DNRLAEQVIASVGDDCTLIIWRL-TDEGP----ILAGYPLSSPGISVQFRPSNPNQLIVG 206 Query: 273 GGDNKVTL--WKENLEGKWEPAGEV 295 + + + W NL + E+ Sbjct: 207 ERNGNIRIFDWTLNLSAEENSQTEL 231 >5WLC-LW nrPDB Length = 554 Score = 42.1 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 18/84 (21%), Positives = 39/84 (46%), Gaps = 7/84 (8%) Query: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 +V + +A ++ +D G +AT +D+++KI+++ K + ++ P V Sbjct: 267 LVKLLSA-RGPVNSIAIDRSGYYMATTGADRSMKIWDIRN--FKQLHSVESLPTPGTNVS 323 Query: 61 WAHPKFGTILASCSYDGKVLIWKE 84 + T L + S V +WK+ Sbjct: 324 IS----DTGLLALSRGPHVTLWKD 343 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 41/213 (19%), Positives = 65/213 (30%), Gaps = 37/213 (17%) Query: 81 IWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII 140 I+ E ++ H + + P+ Y LL+ A G + + S + Sbjct: 176 IYDHEGTELHRLKQHI----EARHLDFLPYHY--LLVTAGETGWLKYHDVSTGQLVSELR 229 Query: 141 IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTL 200 A + G ++ V +W + L S Sbjct: 230 TKA---------------GPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSA- 273 Query: 201 EGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRA 260 V +A Y+A+ DR+ IW N K L E P Sbjct: 274 ---RGPVNSIAID---RSGYYMATTGADRSMKIWDIRN-----FKQLHSVESLPTPGTNV 322 Query: 261 SWSLSGNVLALSGGDNKVTLWKENLE--GKWEP 291 S S +G + G VTLWK+ L+ G +P Sbjct: 323 SISDTGLLALSRGP--HVTLWKDALKLSGDSKP 353 Score = 36.3 bits (82), Expect = 0.018, Method: Composition-based stats. Identities = 19/116 (16%), Positives = 39/116 (33%), Gaps = 10/116 (8%) Query: 13 HDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILAS 72 + + + S+ T+ ++ L+ L+ GPV + + G +A+ Sbjct: 236 MAMAQNPWNAVMHLGHSNGTVSLWSPSMPE-PLVKLLSA-RGPVNSIAI--DRSGYYMAT 291 Query: 73 CSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 D + IW N + Q+ +V + LL S V++ Sbjct: 292 TGADRSMKIWDIRN--FKQLHSVESLPTPGTNVSISDTG----LLALSRGPHVTLW 341 Score = 34.0 bits (76), Expect = 0.073, Method: Composition-based stats. Identities = 25/161 (15%), Positives = 56/161 (34%), Gaps = 22/161 (13%) Query: 38 VEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAV 97 + + L H +D+ + +L + G + G+ V + Sbjct: 176 IYDHEGTELHRLKQHIEA-RHLDFLPYHY--LLVTAGETGWLKYHDVSTGQ----LVSEL 228 Query: 98 HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPAT 157 + + ++ A + + ++ + S+G VS+ + + + + VNS + Sbjct: 229 RTKAGPTMAMAQNPWNAVMHLGHSNGTVSLW--SPSMPEPLVKLLSARGPVNSIAID--- 283 Query: 158 IEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLES 198 + T GAD +KIW + Q + +ES Sbjct: 284 ----------RSGYYMATTGADRSMKIWDIRNFKQLHSVES 314 >6IYY-A nrPDB Length = 317 Score = 41.3 bits (95), Expect = 5e-04, Method: Composition-based stats. Identities = 17/85 (20%), Positives = 35/85 (41%), Gaps = 3/85 (3%) Query: 5 ANAHNELIHDAVLDYYGKRLATCSSDKT-IKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 AH ++ L+ G R+AT S T I+IF+ ++ +++ Sbjct: 172 IPAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFN- 230 Query: 64 PKFGTILASCSYDGKVLIWKEENGR 88 + +++ S G V I+ E+ + Sbjct: 231 -QDASLICVSSDHGTVHIFAAEDPK 254 >2VDU-B nrPDB Length = 450 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 30/183 (16%), Positives = 56/183 (30%), Gaps = 17/183 (9%) Query: 100 ASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIE 159 + + +++ E L+ A SD + V + + + S P I Sbjct: 103 SYIRNLRLTSDES-RLIACADSDKSLLVFDVDKTSKNVLKLRKR-----FCFSKRPNAIS 156 Query: 160 EDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLR 219 + + KF G + I + + E L GH + DV Sbjct: 157 IAEDDTTVIIADKF---GDVYSIDINSIPE--EKFTQEPIL-GHVSMLTDVHLIKDSDGH 210 Query: 220 SYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVT 279 ++ + +D I K L + F + +L +GGD+K+ Sbjct: 211 QFIITSDRDEHIKISHYPQC-FIVDKWLFGHKHFVSSIC----CGKDYLLLSAGGDDKIF 265 Query: 280 LWK 282 W Sbjct: 266 AWD 268 Score = 37.1 bits (84), Expect = 0.009, Method: Composition-based stats. Identities = 20/92 (21%), Positives = 34/92 (36%), Gaps = 7/92 (7%) Query: 7 AHNELIHDAVL--DYYGKR-LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 H ++ D L D G + + T D+ IKI + + L GH+ V + Sbjct: 193 GHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI-SHYPQCFIVDKWLFGHKHFVSSICCGK 251 Query: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVH 95 +L S D K+ W + G+ + Sbjct: 252 DY---LLLSAGGDDKIFAWDWKTGKNLSTFDY 280 >3JB9-S nrPDB Length = 488 Score = 37.9 bits (86), Expect = 0.005, Method: Composition-based stats. Identities = 24/124 (19%), Positives = 46/124 (37%), Gaps = 14/124 (11%) Query: 8 HNELIHDAVLDYYGKRLA-TCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 H+ + G L T + D I I+++ L + V V Sbjct: 374 HSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQKIPL---QTKVAAVSL--DIT 428 Query: 67 GTILASCSYDG---KVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 +L S DG V I+ + + W ++ H +S++++ W +E LL S+ Sbjct: 429 SQLLVSS--DGETLYVHIYVKSSKSWRCMSQ--THVSSISNLVW-LNELHQLLFSTSNGA 483 Query: 124 KVSV 127 + + Sbjct: 484 ILRL 487 Score = 33.2 bits (74), Expect = 0.13, Method: Composition-based stats. Identities = 32/198 (16%), Positives = 60/198 (30%), Gaps = 33/198 (16%) Query: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 AHP G L + S + I+ ++ ++ A H + S+ P G L + Sbjct: 303 AHP-SGEYLLAASNEK-CYIFSLKSQVYN--ITVAQH---ITSLAVHPD--GNLFVAGLE 353 Query: 122 DGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNL 181 +G++ E + + P + G VT D+ Sbjct: 354 NGELRFFETSSGNELTK--------------FGPHSSPVKTLQFGENGYWLVVTTNDDSD 399 Query: 182 VKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQG 241 + IW D + L + + V V+ + S L S T + Sbjct: 400 IFIW----DLRKSELVQKIPLQTK-VAAVSLD----ITSQLLVSSDGETLYVHIYVKSSK 450 Query: 242 PWKKTLLKE-EKFPDVLW 258 W+ +++W Sbjct: 451 SWRCMSQTHVSSISNLVW 468 >4YHC-A nrPDB Length = 468 Score = 36.7 bits (83), Expect = 0.011, Method: Composition-based stats. Identities = 19/84 (22%), Positives = 33/84 (39%), Gaps = 6/84 (7%) Query: 192 QTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEE 251 + + +E H + +A S ASV DR+ ++W K +L +E Sbjct: 18 EKFRIEPVPVHHQLDILKIAVSENY---KTFASVGLDRSLVVWDLRQ---WCTKLVLSKE 71 Query: 252 KFPDVLWRASWSLSGNVLALSGGD 275 + P L + GN ++L D Sbjct: 72 QMPRTLKAIALDPQGNYVSLFSKD 95 Score = 28.2 bits (61), Expect = 4.0, Method: Composition-based stats. Identities = 19/107 (17%), Positives = 38/107 (35%), Gaps = 3/107 (2%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 H I + K A+ D+++ ++++ KL+ L+ + P A G Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLV--LSKEQMPRTLKAIALDPQG 86 Query: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGP 114 ++ S D + I E+ + S +V W P + Sbjct: 87 NYVSLFSKD-TLFILNVESPSLMLQHSYHSKPNSKLNVFWMPGTHKD 132 >5GRS-A nrPDB Length = 396 Score = 35.9 bits (81), Expect = 0.019, Method: Composition-based stats. Identities = 19/84 (22%), Positives = 32/84 (38%), Gaps = 6/84 (7%) Query: 192 QTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEE 251 + + +E H + +A S ASV DR ++W K +L +E Sbjct: 18 EKFRIEPVPVHHQLDILKIAVSENY---KTFASVGLDRCLVVWDLRQ---WCTKLVLSKE 71 Query: 252 KFPDVLWRASWSLSGNVLALSGGD 275 + P L + GN ++L D Sbjct: 72 QMPRTLKAIALDPQGNYVSLFSKD 95 Score = 29.4 bits (64), Expect = 2.1, Method: Composition-based stats. Identities = 13/141 (9%), Positives = 45/141 (31%), Gaps = 10/141 (7%) Query: 52 HEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHE 111 H+ + ++ + + AS D +++W + ++ ++ P Sbjct: 29 HQLDILKIAVS--ENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQ- 85 Query: 112 YGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESR 171 G + + S D + ++ + + W P T + ++ Sbjct: 86 -GNYVSLFSKD-TLFILNVESPSLMLQHSYHCKPNSKLNVFWMPGT-----HKDDEWKNF 138 Query: 172 KFVTGGADNLVKIWKYNSDAQ 192 + V + ++++ + + Sbjct: 139 ELVVVESSGEIQVFSLTIEIE 159 Score = 27.9 bits (60), Expect = 5.2, Method: Composition-based stats. Identities = 13/74 (17%), Positives = 28/74 (37%), Gaps = 2/74 (2%) Query: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 H I + K A+ D+ + ++++ KL+ L+ + P A G Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLV--LSKEQMPRTLKAIALDPQG 86 Query: 68 TILASCSYDGKVLI 81 ++ S D ++ Sbjct: 87 NYVSLFSKDTLFIL 100 >6N8P-A nrPDB Length = 979 Score = 35.2 bits (79), Expect = 0.034, Method: Composition-based stats. Identities = 44/265 (16%), Positives = 74/265 (27%), Gaps = 51/265 (19%) Query: 63 HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD 122 HP+ + G V+IW + S++ H + S + ++ W G LL+ SD Sbjct: 186 HPRDPNQILIGYSRGLVVIWDLQG---SRVLYHFLSSQQLENIWWQ--RDGRLLVSCHSD 240 Query: 123 GKVSVVEFKENGTTSP---IIIDAHAIGVNSAS---W------APATIEEDGEHNGTKES 170 G ++ + + W P TI + G + Sbjct: 241 GSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGD 300 Query: 171 RKFVTGGADNLVKIWKYNSDA---------------QTYVLESTLEGHSDWVRDVA---W 212 R ++ D + + S L V D+ W Sbjct: 301 RHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVIDLQTAGW 360 Query: 213 SPTVLLRSYLAS--VSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGN--- 267 P L YLAS S TC + W++ + + W + G Sbjct: 361 PPVQL--PYLASLHCSA-ITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSL 417 Query: 268 --------VLALSGGDNKVTLWKEN 284 +L D V W + Sbjct: 418 TPAPPQRDLLLTGHEDGTVRFWDAS 442 Score = 31.3 bits (69), Expect = 0.51, Method: Composition-based stats. Identities = 7/32 (21%), Positives = 14/32 (43%) Query: 19 YYGKRLATCSSDKTIKIFEVEGETHKLIDTLT 50 L T D T++ ++ G +L+ L+ Sbjct: 422 PQRDLLLTGHEDGTVRFWDASGVCLRLLYKLS 453 Score = 31.3 bits (69), Expect = 0.54, Method: Composition-based stats. Identities = 23/122 (18%), Positives = 48/122 (39%), Gaps = 18/122 (14%) Query: 26 TCS---SDKTIKIFE--VEGETHKLIDTLTGHEGPV---WRVDWAHPKFGTILASCSYDG 77 TCS S+ +K++E + + + + E P+ + A P+ +L + DG Sbjct: 377 TCSHHVSNIPLKLWERIIAAGSRQNAH-FSTMEWPIDGGTSLTPAPPQR-DLLLTGHEDG 434 Query: 78 KVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTS 137 V W +G ++ + + + V P+E S+ G+ ++ G+ Sbjct: 435 TVRFWD-ASGVCLRLL-YKLSTVRVFLTDTDPNEN------FSAQGEDEWPPLRKVGSFD 486 Query: 138 PI 139 P Sbjct: 487 PY 488 >5CWW-B nrPDB Length = 595 Score = 32.5 bits (72), Expect = 0.23, Method: Composition-based stats. Identities = 19/101 (18%), Positives = 30/101 (29%), Gaps = 19/101 (18%) Query: 204 SDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQ---------DNEQGPWKKTLLKEEKFP 254 +D +R + SP + L S T I D K L Sbjct: 114 ADDIRQLVMSPNQDFLAVLTS----HTVHICILPDSSHLHIQDTTPFKPKFWTLGPTTHV 169 Query: 255 ---DVLWRASWSL---SGNVLALSGGDNKVTLWKENLEGKW 289 + A W +G+ L D V +W+ + +W Sbjct: 170 TSRSAVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTADRW 210 >2DFV-A nrPDB Length = 347 Score = 29.8 bits (65), Expect = 1.4, Method: Composition-based stats. Identities = 15/74 (20%), Positives = 23/74 (31%), Gaps = 6/74 (8%) Query: 46 IDTLTGHEGPVWRVDWAHPKFGTILAS------CSYDGKVLIWKEENGRWSQIAVHAVHS 99 + T G+ + VD P G +L C D + W E + H Sbjct: 8 MKTKPGYGAELVEVDVPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIKPPQIMGHE 67 Query: 100 ASVNSVQWAPHEYG 113 + V+ P G Sbjct: 68 VAGEVVEIGPGVEG 81 >5LTD-A nrPDB Length = 525 Score = 29.4 bits (64), Expect = 1.9, Method: Composition-based stats. Identities = 15/80 (18%), Positives = 27/80 (33%), Gaps = 3/80 (3%) Query: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKT-IKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 + AH + L G LAT S T I++F V + ++ + + Sbjct: 216 SVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAF 275 Query: 62 AHPKFGTILASCSYDGKVLI 81 + + + S V I Sbjct: 276 SPDN--RFVIASSATETVHI 293 >6C94-A nrPDB Length = 497 Score = 29.0 bits (63), Expect = 2.7, Method: Composition-based stats. Identities = 17/135 (12%), Positives = 40/135 (29%), Gaps = 11/135 (8%) Query: 33 IKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASC--SYDGKVLIWKEENGRWS 90 + + E+ + ID+ H ++ W P L +C ++D + ++ Sbjct: 191 VAVSELTLLMQQRIDSFQYHNDFIY---WLTPHGRRFLRACRAAHDHTDRVIRQRKAALQ 247 Query: 91 QIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNS 150 + + +LL + V + + + + H + Sbjct: 248 DEKEREKIQNR-RHLDFL-----DILLDVRGESGVQLSDTDLRAEVDTFMFEGHDTTTSG 301 Query: 151 ASWAPATIEEDGEHN 165 SW + EH Sbjct: 302 ISWFLYCMALYPEHQ 316 >5BPT-A nrPDB Length = 741 Score = 28.6 bits (62), Expect = 3.5, Method: Composition-based stats. Identities = 18/72 (25%), Positives = 29/72 (40%), Gaps = 5/72 (6%) Query: 206 WVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLS 265 + +AWSP R +A V++ ++ N Q W +L E + +W Sbjct: 15 EIIFLAWSPK---RDLIALVNKAGEVLLHRLANIQRVW--SLPPNENTGKEVTCLAWRPD 69 Query: 266 GNVLALSGGDNK 277 G +LA D K Sbjct: 70 GKILAFGLADTK 81 >5KIA-A nrPDB Length = 351 Score = 28.2 bits (61), Expect = 4.1, Method: Composition-based stats. Identities = 9/71 (12%), Positives = 21/71 (29%), Gaps = 1/71 (1%) Query: 73 CSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV-ASSDGKVSVVEFK 131 C D + W + + + +H H V+ G + S +G ++ + Sbjct: 46 CGTDIHIWKWDDWAQKTIPVPMHVGHEYVGEIVEMGQEVRGFSIGDRVSGEGHITCGFCR 105 Query: 132 ENGTTSPIIID 142 + Sbjct: 106 NCRAGRRHLCR 116 >1OI2-A nrPDB Length = 366 Score = 28.2 bits (61), Expect = 4.6, Method: Composition-based stats. Identities = 8/26 (30%), Positives = 13/26 (50%) Query: 66 FGTILASCSYDGKVLIWKEENGRWSQ 91 F T+L + SY + W + G W + Sbjct: 249 FDTLLVNGSYHRTLRFWDYQQGSWQE 274 >3TKN-A nrPDB Length = 452 Score = 28.2 bits (61), Expect = 4.8, Method: Composition-based stats. Identities = 25/150 (16%), Positives = 49/150 (32%), Gaps = 23/150 (15%) Query: 149 NSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI----WKYN--SDAQ--------TY 194 +S +++ + +D H + S + DN + + W Y+ D Y Sbjct: 55 HSLNFSRHLVLDDTFHVISSTSGDLLCLFNDNEIFVMEVPWGYSNVEDVSIQDAFQIFHY 114 Query: 195 VLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKF- 253 ++ G ++ V + P S + + +D T ++ N Q F Sbjct: 115 SIDEEEVGPKSSIKKVLFHPKSYRDSCIVVLKEDDTITMFDILNSQEKPIVLNKPNNSFG 174 Query: 254 ----PDVLWRASWSLSGNVL----ALSGGD 275 + + +S G L GGD Sbjct: 175 LDARVNDITDLEFSKDGLTLYCLNTTEGGD 204 >1D0M-A nrPDB Length = 322 Score = 27.9 bits (60), Expect = 5.0, Method: Composition-based stats. Identities = 8/40 (20%), Positives = 16/40 (40%) Query: 106 QWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHA 145 Q+ P Y + S DG +++ + + + AH Sbjct: 186 QFMPSSYKQYAVDFSGDGHINLWDPVDAIGSVANYFKAHG 225 >2XZ5-A nrPDB Length = 217 Score = 27.5 bits (59), Expect = 7.0, Method: Composition-based stats. Identities = 18/80 (22%), Positives = 32/80 (40%), Gaps = 4/80 (5%) Query: 102 VNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGV----NSASWAPAT 157 +NS+ W P+EYG + +S + + +T P+ + + I V S + PA Sbjct: 60 LNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQ 119 Query: 158 IEEDGEHNGTKESRKFVTGG 177 +S + VT Sbjct: 120 RLSFMCDPTGVDSEEGVTCA 139 >1X3Z-A nrPDB Length = 335 Score = 27.5 bits (59), Expect = 7.4, Method: Composition-based stats. Identities = 6/43 (13%), Positives = 16/43 (37%) Query: 255 DVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 ++ +W+ + G D V + K + P ++ + Sbjct: 237 PYIYSINWNKKMSYCIAFGKDGVVDVSKRYILQNELPRDQIKE 279 >1S18-A nrPDB Length = 331 Score = 27.5 bits (59), Expect = 7.4, Method: Composition-based stats. Identities = 33/217 (15%), Positives = 67/217 (30%), Gaps = 14/217 (6%) Query: 61 WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS 120 +++ K G + S S D + W +++G ++ + G L V Sbjct: 56 FSYLKKGYLTLSDSGDKVAVEWDKDHGVLESHLAEKGRGMELSDLIV---FNGKLYSV-- 110 Query: 121 SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 D V + + + +I+ V A +D +++ T D Sbjct: 111 DDRTGVVYQIEGSKAVPWVILSDGDGTVEKGFKAEWLAVKDERLYVGGLGKEWTTTTGD- 169 Query: 181 LVKIWKYNSDAQTYVLESTLEGHSDWV---RDVAWSPTVLLRSYLA--SVSQDRTCIIWT 235 + N + V H +WV + + + YL S T W Sbjct: 170 ---VVNENPEWVKVVGYKGSVDHENWVSNYNALRAAAGIQPPGYLIHESACWSDTLQRWF 226 Query: 236 QDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALS 272 + ++ K+++ S S +A+S Sbjct: 227 FLPRRASQERYSEKDDERKGANLLLSASPDFGDIAVS 263 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.122 0.343 Lambda K H 0.267 0.0372 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,162,369 Number of Sequences: 36641 Number of extensions: 464076 Number of successful extensions: 4893 Number of sequences better than 10.0: 152 Number of HSP's better than 10.0 without gapping: 178 Number of HSP's successfully gapped in prelim test: 95 Number of HSP's that attempted gapping in prelim test: 970 Number of HSP's gapped (non-prelim): 1039 length of query: 297 length of database: 10,336,785 effective HSP length: 96 effective length of query: 201 effective length of database: 6,819,249 effective search space: 1370669049 effective search space used: 1370669049 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.8 bits) S2: 58 (27.1 bits)