BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q04446 (702 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5CLW-A nrPDB 1382 0.0 3AMK-A nrPDB 751 0.0 5GQY-A nrPDB 197 1e-50 3K1D-A nrPDB 183 2e-46 5E70-A nrPDB 170 2e-42 1EHA-A nrPDB 87 3e-17 2BHU-A nrPDB 82 1e-15 3M07-A nrPDB 72 7e-13 4OKD-A nrPDB 67 3e-11 4E2O-A nrPDB 61 1e-09 4GKL-A nrPDB 60 4e-09 2VNC-A nrPDB 57 2e-08 5A2B-A nrPDB 56 6e-08 2E8Y-A nrPDB 55 7e-08 5H05-A nrPDB 54 3e-07 3FAW-A nrPDB 53 4e-07 2YA2-A nrPDB 53 5e-07 1WZA-A nrPDB 52 8e-07 5H2T-A nrPDB 51 1e-06 1J0H-A nrPDB 50 3e-06 2WSK-A nrPDB 50 5e-06 2WAN-A nrPDB 49 9e-06 3WDH-A nrPDB 47 2e-05 5M99-B nrPDB 47 3e-05 3DHU-A nrPDB 45 1e-04 5BRQ-A nrPDB 45 1e-04 1SMA-A nrPDB 45 1e-04 4CGT-A nrPDB 44 2e-04 6JEQ-A nrPDB 44 2e-04 2AAA-A nrPDB 44 3e-04 5ZCD-A nrPDB 43 4e-04 2ZE0-A nrPDB 43 4e-04 1EA9-C nrPDB 43 4e-04 4LXF-A nrPDB 43 5e-04 1V3M-A nrPDB 43 5e-04 1LWJ-A nrPDB 43 6e-04 3ZO9-A nrPDB 42 7e-04 5WCZ-A nrPDB 42 9e-04 5OT1-A nrPDB 41 0.001 3WY1-A nrPDB 41 0.002 1BF2-A nrPDB 40 0.004 3EDF-A nrPDB 40 0.004 3VM7-A nrPDB 40 0.005 2WC7-A nrPDB 40 0.005 1CYG-A nrPDB 39 0.010 2TAA-A nrPDB 38 0.016 1MXD-A nrPDB 37 0.020 1UOK-A nrPDB 37 0.025 1IV8-A nrPDB 37 0.029 2Z1K-A nrPDB 37 0.033 1EO7-A nrPDB 37 0.034 5X7U-A nrPDB 37 0.039 3WN6-A nrPDB 37 0.042 1JL8-A nrPDB 37 0.042 4AIE-A nrPDB 37 0.042 1AVA-A nrPDB 36 0.053 3K8L-A nrPDB 36 0.074 1GJU-A nrPDB 35 0.077 3QGV-A nrPDB 35 0.083 4GI8-A nrPDB 35 0.084 2DIE-A nrPDB 35 0.091 3UER-A nrPDB 35 0.10 3AXH-A nrPDB 35 0.13 5YKB-A nrPDB 35 0.14 4J3X-A nrPDB 34 0.21 1A47-A nrPDB 33 0.38 4JCM-A nrPDB 33 0.47 1QHO-A nrPDB 33 0.52 4UZU-A nrPDB 33 0.54 4AEF-A nrPDB 33 0.62 3BH4-A nrPDB 32 0.64 1E3X-A nrPDB 32 0.85 3HJE-A nrPDB 32 0.88 3BSH-A nrPDB 32 0.91 3T99-A nrPDB 32 1.0 4AEE-A nrPDB 32 1.4 2ZIC-A nrPDB 31 1.5 6AIJ-A nrPDB 31 1.9 1M53-A nrPDB 31 2.0 5VTM-X nrPDB 31 2.1 4CZY-B nrPDB 30 2.4 4HOX-A nrPDB 30 2.6 3GBE-A nrPDB 30 3.0 2D3L-A nrPDB 30 4.9 1QI5-A nrPDB 30 4.9 3EHC-A nrPDB 30 5.3 1BPL-A nrPDB 29 5.5 1GCY-A nrPDB 29 5.7 1BLI-A nrPDB 29 5.9 4CYJ-A nrPDB 29 7.3 6GXV-A nrPDB 29 7.5 5ZCR-A nrPDB 28 9.3 >5CLW-A nrPDB Length = 668 Score = 1382 bits (3578), Expect = 0.0, Method: Compositional matrix adjust. Identities = 661/663 (99%), Positives = 663/663 (100%) Query: 38 LKPYAVDFQRRYKQFSQILKNIGENEGGIDKFSRGYESFGVHRCADGGLYCKEWAPGAEG 97 LKPYAVDFQRRYKQFSQILKNIGENEGGIDKFSRGYESFGVHRCADGGLYCKEWAPGAEG Sbjct: 6 LKPYAVDFQRRYKQFSQILKNIGENEGGIDKFSRGYESFGVHRCADGGLYCKEWAPGAEG 65 Query: 98 VFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGSKLKVVITSKSGEILYRI 157 VFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGSKLKVVITSKSGEILYRI Sbjct: 66 VFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGSKLKVVITSKSGEILYRI 125 Query: 158 SPWAKYVVREGDNVNYDWIHWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYK 217 SPWAKYVVREGDNVNYDWIHWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYK Sbjct: 126 SPWAKYVVREGDNVNYDWIHWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYK 185 Query: 218 HFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAH 277 HFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYG+PEELQELVDTAH Sbjct: 186 HFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGSPEELQELVDTAH 245 Query: 278 SMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRLFAYSSWEILRF 337 SMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRLFAYSSWE+LRF Sbjct: 246 SMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRLFAYSSWEVLRF 305 Query: 338 LLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLAN 397 LLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLAN Sbjct: 306 LLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLAN 365 Query: 398 HLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNM 457 HLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNM Sbjct: 366 HLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNM 425 Query: 458 GDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGI 517 GDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGI Sbjct: 426 GDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGI 485 Query: 518 QLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGNNESYHYARRQFHLTDDDLLRY 577 QLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGNNESYHYARRQFHLTDDDLLRY Sbjct: 486 QLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGNNESYHYARRQFHLTDDDLLRY 545 Query: 578 KFLNNFDRDMNRLEERYGWLAAPQAYVSEKHEGNKIIAFERAGLLFIFNFHPSKSYTDYR 637 KFLNNFDRDMNRLEERYGWLAAPQAYVSEKHEGNKIIAFERAGLLFIFNFHPSKSYTDYR Sbjct: 546 KFLNNFDRDMNRLEERYGWLAAPQAYVSEKHEGNKIIAFERAGLLFIFNFHPSKSYTDYR 605 Query: 638 VGTALPGKFKIVLDSDAAEYGGHQRLDHSTDFFSEAFEHNGRPYSLLVYIPSRVALILQN 697 VGTALPGKFKIVLDSDAAEYGGHQRLDHSTDFFSEAFEHNGRPYSLLVYIPSRVALILQN Sbjct: 606 VGTALPGKFKIVLDSDAAEYGGHQRLDHSTDFFSEAFEHNGRPYSLLVYIPSRVALILQN 665 Query: 698 VDL 700 VDL Sbjct: 666 VDL 668 >3AMK-A nrPDB Length = 702 Score = 751 bits (1940), Expect = 0.0, Method: Compositional matrix adjust. Identities = 366/684 (53%), Positives = 472/684 (69%), Gaps = 17/684 (2%) Query: 31 LLEIDPYLKPYAVDFQRRYKQFSQILKNIGENEGGIDKFSRGYESFGVHRCADGGLYCKE 90 + ++DP L+ + F R K++ I ++EGG+++FS+GY FG++ DG +E Sbjct: 13 IYDLDPKLEEFKDHFNYRIKRYLDQKCLIEKHEGGLEEFSKGYLKFGIN-TVDGATIYRE 71 Query: 91 WAPGAEGVFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGSKLKVVITSKS 150 WAP A+ L G+FN WN + +K +G W + I K +PH SK+K Sbjct: 72 WAPAAQEAQLIGEFNNWNGAKHKMEKDKFGIWSIKISHVNGKPA-IPHNSKVKFRFRHGG 130 Query: 151 GEILYRISPWAKYVVREGDNVN--YDWIHWDPE--HSYEFKHSRPKKPRSLRIYESHVGI 206 G + RI W +Y + YD +HWDP Y FKH RP KP + RIYE+HVG+ Sbjct: 131 GAWVDRIPAWIRYATFDASKFGAPYDGVHWDPPACERYVFKHPRPPKPDAPRIYEAHVGM 190 Query: 207 SSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTP 266 S E +V++Y+ F NVLPRI+ YN +QLMAIMEH+YYASFGY +T+FFA SSR GTP Sbjct: 191 SGEEPEVSTYREFADNVLPRIRANNYNTVQLMAIMEHSYYASFGYHVTNFFAVSSRSGTP 250 Query: 267 EELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFD---GTDSCYFHSGPRGTHDLWD 323 E+L+ LVD AHS+G+ VL+DVVHSHAS N DGLN +D T YFH+G RG H LWD Sbjct: 251 EDLKYLVDKAHSLGLRVLMDVVHSHASNNVTDGLNGYDVGQNTHESYFHTGDRGYHKLWD 310 Query: 324 SRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGL 383 SRLF Y++WE+LRFLLSN+R+W++E+ FDGFRFDGVTSMLYHHHG+ +GF+G+Y EYF L Sbjct: 311 SRLFNYANWEVLRFLLSNLRYWMDEFMFDGFRFDGVTSMLYHHHGINKGFTGNYKEYFSL 370 Query: 384 QVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKW 443 D DA+ Y+MLANHL+H L P++ +AEDVSGMP LC P+ +GG GFD+RLAMAIPD+W Sbjct: 371 DTDVDAIVYMMLANHLMHKLLPEATIVAEDVSGMPVLCRPVDEGGVGFDFRLAMAIPDRW 430 Query: 444 IQLLKEFKDEDWNMGDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNM 503 I LK +D W+M +IV TLTNRRY EKCIAYAESHDQ++VGDK++AF LMD EMYT M Sbjct: 431 IDYLKNKEDRKWSMSEIVQTLTNRRYTEKCIAYAESHDQSIVGDKTIAFLLMDKEMYTGM 490 Query: 504 SVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGNNESYHYA 563 S L P +P I+RGI L KMI IT LGG+GYLNFMGNEFGHPEW+DFPR+GNN SY Sbjct: 491 SDLQPASPTINRGIALQKMIHFITMALGGDGYLNFMGNEFGHPEWIDFPREGNNWSYDKC 550 Query: 564 RRQFHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAAPQAYVSEKHEGNKIIAFERAGLLF 623 RRQ+ L D D LRYK++N FD+ MN LEE + +L++ + VS+ +E +K+I FER L+F Sbjct: 551 RRQWSLVDTDHLRYKYMNAFDQAMNALEEEFSFLSSSKQIVSDMNEKDKVIVFERGDLVF 610 Query: 624 IFNFHPSKSYTDYRVGTALPGKFKIVLDSDAAEYGGHQRLDHSTDFFSE--------AFE 675 +FNFHP+K+Y Y+VG LPGK+++ LDSDA +GGH R+ H D F+ Sbjct: 611 VFNFHPNKTYKGYKVGCDLPGKYRVALDSDALVFGGHGRVGHDVDHFTSPEGMPGVPETN 670 Query: 676 HNGRPYSLLVYIPSRVALILQNVD 699 N RP S V P R + VD Sbjct: 671 FNNRPNSFKVLSPPRTCVAYYRVD 694 >5GQY-A nrPDB Length = 793 Score = 197 bits (501), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 187/680 (27%), Positives = 310/680 (45%), Gaps = 105/680 (15%) Query: 71 RGYESFGVHRCADGGL---YCKEWAPGAEGVFLTGDFNGWNPFSYPYKKLDYGKWELYIP 127 R YE G H G+ Y WAP A V + GDFN W+ + +K +Y WEL++P Sbjct: 144 RIYEKLGAHVGEINGVKGVYFAVWAPNARNVSVIGDFNNWDGREHQMRKRNYTIWELFVP 203 Query: 128 PKQNKSVLVPHGSKLKVVITSKSGEILYRISPWAKY---------VVREGDNVNYDWIHW 178 + G+ K I + G I + P+ Y +V + DN+ Y W Sbjct: 204 E-------IGSGTVYKYEIKNSEGHIYEKSDPYGFYREVRPNTASIVVDIDNI-YQWH-- 253 Query: 179 DPEHSYEFKHSRPKKPRSLRIYESHVGI----SSHE--------------------GKVA 214 D E + ++S P K + + +YE H+G SS E + Sbjct: 254 DEEWLEKRRNSDPLK-QPVSVYEVHLGSWLHGSSAEKMPLLNGEADPVIVSEWNPGARFL 312 Query: 215 SYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVD 274 SY ++P +K +GY I+L+ I EH + S+GYQ+T F++ +SR+G PE+ VD Sbjct: 313 SYYELAEKLIPYVKDMGYTHIELLPIAEHPFDGSWGYQVTGFYSPTSRFGRPEDFMYFVD 372 Query: 275 TAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPR-GTHDLWDSRLFAYSSWE 333 H GI V+LD V H K+S GL FDGT Y H+ PR G H W + +F Y E Sbjct: 373 KCHENGIGVILDWVPGHFPKDS-HGLAYFDGT-HLYEHADPRIGEHKEWGTLVFNYGRHE 430 Query: 334 ILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYL 393 + FL++N+ +W ++Y DG R D V SMLY ++ +G +EY G + E A++++ Sbjct: 431 VRNFLVANVLFWFDKYHVDGIRVDAVASMLYRNYLRKEG-EWIANEYGGDEHIE-AVSFI 488 Query: 394 MLANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDE 453 N L+ P ++IAE+ + + P+ GG GF+ + M W+ + ++ + Sbjct: 489 REVNTLLFEYFPGILSIAEESTEWEKVSRPVYDGGLGFNLKWDMG----WMHDMLDYFNI 544 Query: 454 D-----WNMGDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTP 508 D ++ ++ +++ Y + A SHD+ + G ++ + E +V Sbjct: 545 DPYFRQYHQNNVTFSML--YYYNENFMLALSHDEIVHGKSNMLGKMPGDEWQKYANVRAL 602 Query: 509 FTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGNNESYHYARRQFH 568 FT + TH G+ + FM EFG +W ++ G+ E +H + + H Sbjct: 603 FT-------------YMYTH--PGKKTM-FMSMEFG--QWSEWNVWGDLE-WHLLQYEPH 643 Query: 569 LTDDDLLRYKFLNNFDRDMNRLEERYGWLAAPQ------AYVSEKHEGNKIIAFERA--- 619 + L F D+N L ++ L ++ + +++F R Sbjct: 644 ---------QQLKQFFTDLNALYQQEPALYTHDFEYHGFEWIDCNDNTHSVVSFLRRSDD 694 Query: 620 ---GLLFIFNFHPSKSYTDYRVGTALPGKFKIVLDSDAAEYGGHQRLDHSTDFFSEAFEH 676 L+ + NF P + ++ YR+G G + + +SDA +YGG + + E H Sbjct: 695 PNDSLVVVCNFTP-QPHSHYRIGVPEAGYYVELFNSDAKQYGGSNMGNLGGKWADEWSFH 753 Query: 677 NGRPYSLLVYIPSRVALILQ 696 N +PYSL + +P LIL+ Sbjct: 754 N-KPYSLDLCLPPLAVLILK 772 >3K1D-A nrPDB Length = 722 Score = 183 bits (465), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 184/657 (28%), Positives = 285/657 (43%), Gaps = 79/657 (12%) Query: 68 KFSRGYESFGVH----RCADG---GLYCKEWAPGAEGVFLTGDFNGWNPFSYPYKKLD-Y 119 + R +E G H ADG G+ WAP A+GV L G+FNGWN P + L Sbjct: 113 RHERLWEVLGAHPRSFTTADGVVSGVSFAVWAPNAKGVSLIGEFNGWNGHEAPMRVLGPS 172 Query: 120 GKWELYIPPKQNKSVLVPHGSKLKVVITSKSGEILYRISPWA---KYVVREGDNVNYDWI 176 G WEL+ P P K + G + R P+A + + V Sbjct: 173 GVWELFWPD-------FPCDGLYKFRVHGADGVVTDRADPFAFGTEVPPQTASRVTSSDY 225 Query: 177 HWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQ 236 W + + R ++ YE H+G S G SY+ + I G+ ++ Sbjct: 226 TWGDDDWMAGRALRNPVNEAMSTYEVHLG-SWRPG--LSYRQLARELTDYIVDQGFTHVE 282 Query: 237 LMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNS 296 L+ + EH + S+GYQ+TS++A +SR+GTP++ + LVD H GI V++D V +H K+ Sbjct: 283 LLPVAEHPFAGSWGYQVTSYYAPTSRFGTPDDFRALVDALHQAGIGVIVDWVPAHFPKD- 341 Query: 297 ADGLNMFDGTDSCYFHSGP-RGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFR 355 A L FDGT Y HS P RG W + +F + E+ FL++N +WL+E+ DG R Sbjct: 342 AWALGRFDGT-PLYEHSDPKRGEQLDWGTYVFDFGRPEVRNFLVANALYWLQEFHIDGLR 400 Query: 356 FDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVS 415 D V SMLY + +G G G + + +A+ +L N H + P +TIAE+ + Sbjct: 401 VDAVASMLYLDYSRPEG--GWTPNVHGGRENLEAVQFLQEMNATAHKVAPGIVTIAEEST 458 Query: 416 GMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNMGDIVYTLTNRRYLEKCIA 475 + P + GG GF + M W+ ++ D VY + + + Sbjct: 459 PWSGVTRPTNIGGLGFSMKWNMG----WMHDTLDYVSR-----DPVYRSYHHHEMTFSML 509 Query: 476 YAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEG- 534 YA S + L L E+ L P + ++ + L+ + G Sbjct: 510 YAFSENYVLP--------LSHDEVVHGKGTLWGRMPG-NNHVKAAGLRSLLAYQWAHPGK 560 Query: 535 YLNFMGNEFGH-PEW-----LDFPRKGNNESYHYARRQFHLTDDDLLRYKFLNNFDRDMN 588 L FMG EFG EW LD+ + N + +R +D + L + D Sbjct: 561 QLLFMGQEFGQRAEWSEQRGLDWFQLDENGFSNGIQRLVRDINDIYRCHPALWSLD---- 616 Query: 589 RLEERYGWLAAPQAYVSEKHEGNKIIAFERAG-----LLFIFNFHPSKSYTDYRVGTALP 643 E Y W+ A N +++F R G L +FNF + DYR+G Sbjct: 617 TTPEGYSWIDA-------NDSANNVLSFMRYGSDGSVLACVFNF-AGAEHRDYRLGLPRA 668 Query: 644 GKFKIVLDSDAAEY-----GGHQRLDHSTDFFSEAFEHNGRPYSLLVYIPSRVALIL 695 G+++ VL++DA Y G +D + D + +GRP S ++ +P AL L Sbjct: 669 GRWREVLNTDATIYHGSGIGNLGGVDATDDPW------HGRPASAVLVLPPTSALWL 719 >5E70-A nrPDB Length = 612 Score = 170 bits (431), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 173/656 (26%), Positives = 282/656 (42%), Gaps = 83/656 (12%) Query: 71 RGYESFGVHR-CADG--GLYCKEWAPGAEGVFLTGDFNGWNPFSYPYK-KLDYGKWELYI 126 R YE+ G H DG G WAP A V + G FN W+ +P + + + G WEL+I Sbjct: 4 RPYETLGAHADTMDGVTGTRFSVWAPNARRVSVVGQFNYWDGRRHPMRLRKESGIWELFI 63 Query: 127 PPKQNKSVLVPHGSKLKVVITSKSGEILYRISPWAKYVVREGDNVNYDWIHWDPEHSYEF 186 P N G K + +G + + P+A + + I PE + Sbjct: 64 PGAHN-------GQLYKYEMIDANGNLRLKSDPYAFEAQMRPETASL--ICGLPEKVVQT 114 Query: 187 KHSRPKKP--RSLRIYESHVGI---SSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIM 241 + + + IYE H+G + SY+ ++P K +G+ ++L+ I Sbjct: 115 EERKKANQFDAPISIYEVHLGSWRRHTDNNFWLSYRELADQLVPYAKWMGFTHLELLPIN 174 Query: 242 EHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLN 301 EH + S+GYQ T +A + R+GT ++ + +D AH+ G+ V+LD V H + L Sbjct: 175 EHPFDGSWGYQPTGLYAPTRRFGTRDDFRYFIDAAHAAGLNVILDWVPGHFPTDDF-ALA 233 Query: 302 MFDGTDSCYFHSGPR-GTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVT 360 FDGT+ Y HS PR G H W++ ++ Y E+ FL+ N +W+E + D R D V Sbjct: 234 EFDGTN-LYEHSDPREGYHQDWNTLIYNYGRREVSNFLVGNALYWIERFGIDALRVDAVA 292 Query: 361 SMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPAL 420 SM+Y + +G FG + + +A+ +L N ++ ++T+AE+ + P + Sbjct: 293 SMIYRDYSRKEGEW--IPNEFGGRENLEAIEFLRNTNRILGEQVSGAVTMAEESTDFPGV 350 Query: 421 CSPISQGGGGFDYRLAMAIPDKWIQLLK------EFKDEDWNMGDIVYTLTNRRYLEKCI 474 P GG GF Y+ + + +K ++ + G I+Y T + Sbjct: 351 SRPQDMGGLGFWYKWNLGWMHDTLDYMKLDPVYRQYHHDKLTFG-ILYNYT------ENF 403 Query: 475 AYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEG 534 SHD+ + G KS+ M + + + L + + G+ Sbjct: 404 VLPLSHDEVVHGKKSILD-RMPGDAWQKFANLRAYYGWM--------------WAFPGKK 448 Query: 535 YLNFMGNEFGH-PEW-----LDFPRKGNNESYHYARRQFHLTDDDLLRY---KFLNNFDR 585 L FMGNEF EW LD+ +++H+ ++ L D L Y K ++ D Sbjct: 449 LL-FMGNEFAQGREWNHDASLDWHLLEGGDNWHHGVQR--LVRDLNLTYRHHKAMHELDF 505 Query: 586 DMNRLEERYGWLAAPQA------YVSEKHEGNKIIAFERAGLLFIFNFHPSKSYTDYRVG 639 D E WL +V EGN+II NF P + DYR G Sbjct: 506 DPYGFE----WLVVDDKERSVLIFVRRDKEGNEIIVAS--------NFTPVPRH-DYRFG 552 Query: 640 TALPGKFKIVLDSDAAEYGGHQRLDHSTDFFSEAFEHNGRPYSLLVYIPSRVALIL 695 PGK++ +L++D+ Y G + T E H GR +SL + +P + L Sbjct: 553 INQPGKWREILNTDSMHYHGSNAGNGGTVHSDEIASH-GRQHSLSLTLPPLATIWL 607 >1EHA-A nrPDB Length = 558 Score = 86.7 bits (213), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 57/183 (31%), Positives = 87/183 (47%), Gaps = 10/183 (5%) Query: 181 EHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAI 240 + S EF + K L IYE HVG + EG L +K LG I++M I Sbjct: 86 QESKEFNNETFLKKEDLIIYEIHVGTFTPEGTFEG----VIRKLDYLKDLGITAIEIMPI 141 Query: 241 MEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGL 300 + +GY +A + YG PE ++LVD AH G+ V+LDVV++H + Sbjct: 142 AQFPGKRDWGYDGVYLYAVQNSYGGPEGFRKLVDEAHKKGLGVILDVVYNHVGPEGNYMV 201 Query: 301 NMFDGTDSCYFHSGPRGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVT 360 + G + P G +D S E+ +F+L N+ +W++EY DGFR D V Sbjct: 202 KL--GPYFSQKYKTPWGLTFNFDDA----ESDEVRKFILENVEYWIKEYNVDGFRLDAVH 255 Query: 361 SML 363 +++ Sbjct: 256 AII 258 >2BHU-A nrPDB Length = 602 Score = 81.6 bits (200), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 66/217 (30%), Positives = 92/217 (42%), Gaps = 31/217 (14%) Query: 199 IYESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFA 258 YE HVG + EG + LP +K LG IQ+M + +GY +F+A Sbjct: 129 FYEVHVGTFTPEGTYRA----AAEKLPYLKELGVTAIQVMPLAAFDGQRGWGYDGAAFYA 184 Query: 259 ASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGT 318 + YG PE+L LVD AH +G+ V LDVV++H + N YF Sbjct: 185 PYAPYGRPEDLMALVDAAHRLGLGVFLDVVYNHFGPSG----NYLSSYAPSYFTD---RF 237 Query: 319 HDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYS 378 W L Y+ + R++ N R WL +Y FDG R D M D S Sbjct: 238 SSAWGMGL-DYAEPHMRRYVTGNARMWLRDYHFDGLRLDATPYMT------------DDS 284 Query: 379 EY-----FGLQVDEDALTYLMLANHLVHTLCPDSITI 410 E ++ E T+L+LA H PD +T+ Sbjct: 285 ETHILTELAQEIHELGGTHLLLAED--HRNLPDLVTV 319 >3M07-A nrPDB Length = 618 Score = 72.0 bits (175), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 45/164 (27%), Positives = 74/164 (45%), Gaps = 12/164 (7%) Query: 199 IYESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFA 258 +YE H G + EG + LP + LG I++M + + +GY +A Sbjct: 139 VYEMHTGTFTPEGTFRA----AIAKLPYLAELGVTVIEVMPVAQFGGERGWGYDGVLLYA 194 Query: 259 ASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGT 318 S YGTP++ + +D AH G+ V+LD+V +H N +FH + Sbjct: 195 PHSAYGTPDDFKAFIDAAHGYGLSVVLDIVLNHFGPEG----NYLPLLAPAFFH---KER 247 Query: 319 HDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSM 362 W + + AY + R+++ +WL EY DG RFD + + Sbjct: 248 MTPWGNGI-AYDVDAVRRYIIEAPLYWLTEYHLDGLRFDAIDQI 290 >4OKD-A nrPDB Length = 840 Score = 67.0 bits (162), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 58/205 (28%), Positives = 96/205 (46%), Gaps = 34/205 (16%) Query: 196 SLRIYESHV-GISSHEGKVASYKHFTCNVLPRI---KGLGYNCIQLMAIMEH---AYYAS 248 SL IYE+HV G ++H + ++ R+ K LG N I+L+ + E YY+ Sbjct: 223 SLVIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQ 282 Query: 249 -----------FGYQITSFFAASSRY------GTP-----EELQELVDTAHSMGIIVLLD 286 +GY ++F+ R+ G P +E ++LV H GI V+LD Sbjct: 283 IPGSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILD 342 Query: 287 VVHSHASKNSADGLNM-FDGTDS-CYFHSGPRGTHDLWDS--RLFAYSSWEILRFLLSNI 342 VV +H ++ + G + F G D+ Y+ P G + + + + +F+L + Sbjct: 343 VVFNHTAEGNERGPTISFRGLDNRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCL 402 Query: 343 RWWLEEYRFDGFRFDGVTSMLYHHH 367 + W+ EY DGFRFD + S+L H Sbjct: 403 KHWVTEYHVDGFRFD-LASILTRAH 426 >4E2O-A nrPDB Length = 454 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 43/171 (25%), Positives = 72/171 (42%), Gaps = 17/171 (9%) Query: 201 ESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAAS 260 + +V ++ +G L IK +G+ I L I ++ GY I F+ Sbjct: 28 DQNVNVNDPKGYFGGDLKGVTAKLDYIKEMGFTAIWLTPIFKNMPGGYHGYWIEDFYQVD 87 Query: 261 SRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHD 320 +GT +L+ LV AH + V+LD V +H N + D T +FH P+ Sbjct: 88 PHFGTLGDLKTLVKEAHKRDMKVILDFVANHVGYNHP---WLHDPTKKDWFH--PKKEIF 142 Query: 321 LWDSRLFAYSSW------------EILRFLLSNIRWWLEEYRFDGFRFDGV 359 W+ + + W E+ +L+ +WW++E DG+R D V Sbjct: 143 DWNDQTQLENGWVYGLPDLAQENPEVKTYLIDAAKWWIKETDIDGYRLDTV 193 >4GKL-A nrPDB Length = 422 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 42/144 (29%), Positives = 70/144 (48%), Gaps = 15/144 (10%) Query: 224 LPRIKGLGYNCIQLMAIMEHAYYASFG-----YQITSFFAASSRYGTPEELQELVDTAHS 278 L R+KG+G N + LM I G Y I ++ GT + ++ V AH Sbjct: 31 LERLKGMGINTVWLMPIHPTGVEGRKGTLGSPYAIRDYYEIDLLIGTKGDFKKFVKRAHE 90 Query: 279 MGIIVLLDVVHSHASKNSADGLNMFDGTDSCYF----HSGP-RGTHDLWDSRLFAYSSWE 333 + + VL+D+V +HA+ + N+ +F + P R D D F YS+ E Sbjct: 91 LNMYVLMDMVLNHAAVD-----NVLVKKHPEWFLRDENGNPTRKVPDWSDVVDFDYSNGE 145 Query: 334 ILRFLLSNIRWWLEEYRFDGFRFD 357 + ++++ +R+W+EE+ DGFR D Sbjct: 146 LREYMINMMRYWVEEFDVDGFRCD 169 >2VNC-A nrPDB Length = 718 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 51/224 (22%), Positives = 94/224 (41%), Gaps = 32/224 (14%) Query: 175 WIHWDPEHSYEFKHSRPKKPRSLRIYESHVG------ISSHEGKVASYKHFTC-NVLPRI 227 + WD E +F + + IYE HV + E +Y+ ++ + Sbjct: 155 YFEWDDE---DFIKGKKVPLKDTVIYEVHVKGFTKLRLDLPENIRGTYEGLASEQMISYL 211 Query: 228 KGLGYNCIQLMAIM---------EHAYYASFGYQITSFFAASSRY-------GTPEELQE 271 K LG ++LM + + +GY +FF+ RY G ++ Sbjct: 212 KDLGITTVELMPVFHFIDQRFLTDKGLTNYWGYDPINFFSPECRYSSTGCLGGQVLSFKK 271 Query: 272 LVDTAHSMGIIVLLDVVHSHASKNSADGLNM-FDGTD-SCYFHSGPRGTHDLWD----SR 325 +V+ H+ GI V++DVV++H ++ + G + F G D + Y+ P D Sbjct: 272 MVNELHNAGIEVIIDVVYNHTAEGNHLGPTLSFRGIDNTAYYMLQPDNKRYYLDFTGTGN 331 Query: 326 LFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGV 369 S +++ +L ++R+W+ E DGFRFD ++ + V Sbjct: 332 TLNLSHPRVIQMVLDSLRYWVTEMHVDGFRFDLAAALARELYSV 375 >5A2B-A nrPDB Length = 497 Score = 55.8 bits (133), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 41/149 (27%), Positives = 64/149 (42%), Gaps = 13/149 (8%) Query: 221 CNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMG 280 + L IK +G+ I L I + GY I F+ +GT ++ + LV AH Sbjct: 81 IDKLDYIKEMGFTAIWLTPIFANEKGGYHGYWIEDFYKVEEHFGTLDDFKRLVKEAHKRD 140 Query: 281 IIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGP-----RGTHDLWDSRLF-----AYS 330 + V+LD V +H N LN D +FH ++ + LF A Sbjct: 141 MKVILDFVVNHTGYNHP-WLN--DPAKKDWFHEKKDIFNWANQQEVENGWLFGLPDLAQE 197 Query: 331 SWEILRFLLSNIRWWLEEYRFDGFRFDGV 359 + E+ +L +WW++E DG+R D V Sbjct: 198 NPEVKTYLFDVAKWWIQETDIDGYRLDTV 226 >2E8Y-A nrPDB Length = 718 Score = 55.5 bits (132), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 77/326 (23%), Positives = 128/326 (39%), Gaps = 69/326 (21%) Query: 76 FGVHRCADGGLYCKEWAPGAEGVFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVL 135 G AD ++ K WAP A + + ++ +L+ G + + + Sbjct: 106 LGAVYTADHTVF-KVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDL----- 159 Query: 136 VPHGSKLKVVITSKSGEILYRISPWAKYVVREGDN---VNYDWIHWDPEHSYEFKHSRPK 192 HG + I + S E + + +AK V G+ + D + W + P Sbjct: 160 --HGYEYLFCICNNS-EWMETVDQYAKAVTVNGEKGVVLRPDQMKW----------TAPL 206 Query: 193 KPRS----LRIYESHV---GISSHEGKVASYKHF------------TCNVLPRIKGLGYN 233 KP S IYE+H+ I + G + K+ + + L +K LG Sbjct: 207 KPFSHPVDAVIYETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVT 266 Query: 234 CIQLMAIMEHAYYA--------SFGYQITSFFAASSRYGT----PE----ELQELVDTAH 277 ++L+ + + A ++GY FFA Y + P+ EL+++++T H Sbjct: 267 HVELLPVNDFAGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLH 326 Query: 278 SMGIIVLLDVVHSHASKNSADGLNM-----FDGTDSCYFHSGPRGT-HDLWDSRLFAYSS 331 G+ V+LDVV +H K F D C S G +D+ R A Sbjct: 327 QHGLRVILDVVFNHVYKRENSPFEKTVPGYFFRHDECGKPSNGTGVGNDIASERRMAR-- 384 Query: 332 WEILRFLLSNIRWWLEEYRFDGFRFD 357 +F+ + +WLEEY DGFRFD Sbjct: 385 ----KFIADCVVYWLEEYNVDGFRFD 406 >5H05-A nrPDB Length = 640 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 45/163 (27%), Positives = 69/163 (42%), Gaps = 31/163 (19%) Query: 205 GISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIME------HAYYA----SFGYQIT 254 G S H+G + + L I+ LG N I L I + ++A + GY + Sbjct: 38 GTSHHKGDLQG----IIDSLDYIESLGMNAIWLTPIFDSIPVEGQDHWADRLDATGYFTS 93 Query: 255 SFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSG 314 ++FA R+GT E+ +ELV+ AH G+ V D V H N Sbjct: 94 NYFAVDPRFGTMEQAKELVEKAHEKGLYVFFDGVFGHHKDNVV---------------PS 138 Query: 315 PRGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFD 357 P G + ++ +Y E L F +W+EE + DG+R D Sbjct: 139 PEGRLPVGENNPVSYP--ESLAFYQEVATFWIEELKIDGWRLD 179 >3FAW-A nrPDB Length = 877 Score = 53.1 bits (126), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 54/197 (27%), Positives = 89/197 (45%), Gaps = 47/197 (23%) Query: 199 IYESHV----GISSHEGKV----ASYKHFTCNVLPRIKGLGYNCIQLMAIMEH------- 243 IYE+HV S +GK+ ++ F+ L ++ LG IQL+ ++ + Sbjct: 270 IYEAHVRDFTSDQSLDGKLKNQLGTFAAFSEK-LDYLQKLGVTHIQLLPVLSYFYVNEMD 328 Query: 244 -----AYYAS-----FGYQITSFFAASSRYGTP--------EELQELVDTAHSMGIIVLL 285 AY +S +GY S+FA S Y EL++L+ H G+ V+L Sbjct: 329 KSRSTAYTSSDNNYNWGYDPQSYFALSGMYSEKPKDPSARIAELKQLIHDIHKRGMGVIL 388 Query: 286 DVVHSHASKNSADGLNMFDGTDSCYFH-----SGPRGTHDLWDSRLFAYSSWEILRFLLS 340 DVV++H +K +F+ + Y+H PR + RL + R L+ Sbjct: 389 DVVYNHTAKTY-----LFEDIEPNYYHFMNEDGSPRES--FGGGRLGTTHAMS-RRVLVD 440 Query: 341 NIRWWLEEYRFDGFRFD 357 +I++ E++ DGFRFD Sbjct: 441 SIKYLTSEFKVDGFRFD 457 >2YA2-A nrPDB Length = 708 Score = 52.8 bits (125), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 48/198 (24%), Positives = 91/198 (45%), Gaps = 48/198 (24%) Query: 199 IYESHVGISSHEGKVA--------SYKHFTCNVLPRIKGLGYNCIQLMAIMEHAY----- 245 IYE+HV + + +A +++ F L +K LG IQL+ ++ + + Sbjct: 155 IYEAHVRDFTSDPAIAKDLTKPFGTFEAF-IEKLDYLKDLGVTHIQLLPVLSYYFVNELK 213 Query: 246 -------YAS------FGYQITSFFAASSRYGT----PE----ELQELVDTAHSMGIIVL 284 YAS +GY ++F+ + Y + PE E + L++ H G+ + Sbjct: 214 NHERLSDYASSNSNYNWGYDPQNYFSLTGMYSSDPKNPEKRIAEFKNLINEIHKRGMGAI 273 Query: 285 LDVVHSHASKNSADGLNMFDGTDSCYFH-----SGPRGTHDLWDSRLFAYSSWEILRFLL 339 LDVV++H +K +++F+ + Y+H PR + + + R L+ Sbjct: 274 LDVVYNHTAK-----VDLFEDLEPNYYHFMDADGTPRTS---FGGGRLGTTHHMTKRLLI 325 Query: 340 SNIRWWLEEYRFDGFRFD 357 +I++ ++ Y+ DGFRFD Sbjct: 326 DSIKYLVDTYKVDGFRFD 343 >1WZA-A nrPDB Length = 488 Score = 52.0 bits (123), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 46/185 (24%), Positives = 75/185 (40%), Gaps = 29/185 (15%) Query: 205 GISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYG 264 GI +G + + I LG N I LM I + Y GY +T ++ + YG Sbjct: 22 GIGDLKGIIEKLDYLNDGDPETIADLGVNGIWLMPIFKSPSYH--GYDVTDYYKINPDYG 79 Query: 265 TPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCY-------------- 310 T E+ +LV+ AH GI V++D+ +H S+ L +S Y Sbjct: 80 TLEDFHKLVEAAHQRGIKVIIDLPINHTSERHPWFLKASRDKNSEYRDYYVWAGPDTDTK 139 Query: 311 ---------FHSGPRGTH--DLWDSRL-FAYSSWEILRFLLSNIRWWLEEYRFDGFRFDG 358 +H P G + W Y++ E+ ++ ++WL++ DGFR DG Sbjct: 140 ETKLDGGRVWHYSPTGMYYGYFWSGMPDLNYNNPEVQEKVIGIAKYWLKQ-GVDGFRLDG 198 Query: 359 VTSML 363 + Sbjct: 199 AMHIF 203 >5H2T-A nrPDB Length = 601 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 93/408 (22%), Positives = 151/408 (37%), Gaps = 70/408 (17%) Query: 186 FKHSRPKKP---RSLRIYESHV-GISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIM 241 F H +P+ P + YE V G S N L ++ LG +CI L+ I Sbjct: 12 FTHEKPRDPYWYKHAVFYEVLVRGFSDSNDDGTGDLRGLINRLDYLQWLGIDCIWLLPIY 71 Query: 242 EHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSH---------A 292 + GY I+ + +G + ELVD AH GI V+ D+V +H A Sbjct: 72 QSPLRDG-GYDISDYTKILPEFGDLGDFVELVDEAHRRGIRVIADLVMNHTSDQHPWFQA 130 Query: 293 SKNSADG----LNMFDGTD---------------SCYFHSGPRGTHDLWDSRLFA----- 328 S+ DG M+ TD S + + RG + W R F+ Sbjct: 131 SRTDPDGPYGDFYMWSDTDDKYPDARIIFVDTEVSNWTYDPVRGQY-YW-HRFFSHQPDL 188 Query: 329 -YSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDE 387 Y + + +L +R+WL + DGFR D V LY G + Sbjct: 189 NYDNPAVQEAMLEVLRFWL-DLGIDGFRLDAV-PYLYAREGT------------NCENLP 234 Query: 388 DALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPI--SQGGGGFDYRLAMAIPDKWIQ 445 + YL V L PD + +AE + PA GG + +A P Sbjct: 235 ETHAYLKRVRAEVDRLYPDRVLLAE-ANQWPADVVEYFGDPATGGDECHMAFHFPVMPRI 293 Query: 446 LLKEFKDEDWNMGDIVYTLTNRRYLEKCI--AYAESHDQ---ALVGDKS----LAFWLMD 496 + +++ + + +I+ + E C + +HD+ +V D+ A + D Sbjct: 294 FMAVRREQRYPISEIM--AQTPKIPENCQWGIFLRNHDELTLEMVTDEERDYMYAEYAKD 351 Query: 497 AEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFG 544 M N+ + P++D ++ + L G L + G+E G Sbjct: 352 PRMKANIGIRRRLAPLLDNDRNQLELFTALLLSLPGSPVL-YYGDEIG 398 >1J0H-A nrPDB Length = 588 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 37/143 (25%), Positives = 60/143 (41%), Gaps = 17/143 (11%) Query: 230 LGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVH 289 LG I L I ++ Y +F +G E L+ L+D H GI V+LD V Sbjct: 188 LGITGIYLTPIFRSP--SNHKYDTADYFEVDPHFGDKETLKTLIDRCHEKGIRVMLDAVF 245 Query: 290 SHASKNSADGLNMFDGTDSC------YFHSGPRGTHDLWDSRLFAY---------SSWEI 334 +H A +++ +S + H P T + FA+ ++ E+ Sbjct: 246 NHCGYEFAPFQDVWKNGESSKYKDWFHIHEFPLQTEPRPNYDTFAFVPQMPKLNTANPEV 305 Query: 335 LRFLLSNIRWWLEEYRFDGFRFD 357 R+LL +W+ E+ DG+R D Sbjct: 306 KRYLLDVATYWIREFDIDGWRLD 328 >2WSK-A nrPDB Length = 657 Score = 49.7 bits (117), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 52/198 (26%), Positives = 88/198 (44%), Gaps = 26/198 (13%) Query: 191 PKKP-RSLRIYESHV-GISSHEGKV-----ASYKHFTCNVLPR-IKGLGYNCIQLMAIME 242 P+ P S IYE+HV G++ ++ +YK V+ +K LG ++L+ + + Sbjct: 144 PRTPWGSTIIYEAHVKGLTYLHPEIPVEIRGTYKALGHPVMINYLKQLGITALELLPVAQ 203 Query: 243 HAYYAS---------FGYQITSFFAASSRYG-TPE----ELQELVDTAHSMGIIVLLDVV 288 A +GY + FA Y +PE E ++ + H GI V+LD+V Sbjct: 204 FASEPRLQRMGLSNYWGYNPVAMFALHPAYACSPETALDEFRDAIKALHKAGIEVILDIV 263 Query: 289 HSHASKNSADG-LNMFDGTDS-CYFHSGPRGTHDLWD--SRLFAYSSWEILRFLLSNIRW 344 +H+++ DG L G D+ Y+ G + W S ++ + + +R+ Sbjct: 264 LNHSAELDLDGPLFSLRGIDNRSYYWIREDGDYHNWTGCGNTLNLSHPAVVDYASACLRY 323 Query: 345 WLEEYRFDGFRFDGVTSM 362 W+E DGFRFD M Sbjct: 324 WVETCHVDGFRFDLAAVM 341 >2WAN-A nrPDB Length = 921 Score = 48.5 bits (114), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 75/315 (23%), Positives = 117/315 (37%), Gaps = 52/315 (16%) Query: 84 GGLYCKE------WAPGAEGV--FLTGDFNGWNPFSYPYKKLDYGKWELYIPPK-QNKSV 134 G +Y K+ WAP A V L G +K D G W+L + +N Sbjct: 319 GNVYSKDATSFRVWAPTASNVQLLLYNSEKGSITKQLEMQKSDNGTWKLQVSGNLENWYY 378 Query: 135 LVPHGSKLKVVITSKSGEILYRISPWAKYV-VREGDNVNYDWIHWDPEHSYEFKHSRPKK 193 L +V + +G + P+A+ + V + D DP P Sbjct: 379 L------YQVTV---NGTTQTAVDPYARAISVNATRGMIVDLKATDPAGWQGDHEQTPAN 429 Query: 194 PRSLRIYESHV---GISSHEG--KVASYKHFT----------CNVLPRIKGLGYNCIQLM 238 P IYE+HV I ++ G Y FT + +K LG +QL Sbjct: 430 PVDEVIYEAHVRDFSIDANSGMKNKGKYLAFTEHGTKGPDHVKTGIDSLKELGITTVQLQ 489 Query: 239 AIME-------HAYYASFGYQITSFFAASSRYGT-PE------ELQELVDTAHSMGIIVL 284 + E ++GY ++ Y T PE EL++L+ + H I V Sbjct: 490 PVEEFNSIDETQPDTYNWGYDPRNYNVPEGAYATTPEGTARITELKQLIQSLHQQRIGVN 549 Query: 285 LDVVHSHASKNSADGLNMFDGTDSCYFHSGPRG--THDLWDSRLFAYSSWEILRFLLSNI 342 +DVV++H + Y+ + G T+ FA +F+L ++ Sbjct: 550 MDVVYNHTFDVMVSDFDKI--VPQYYYRTDSNGNYTNGSGCGNEFATEHPMAQKFVLDSV 607 Query: 343 RWWLEEYRFDGFRFD 357 +W+ EY DGFRFD Sbjct: 608 NYWVNEYHVDGFRFD 622 >3WDH-A nrPDB Length = 710 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 42/160 (26%), Positives = 66/160 (41%), Gaps = 28/160 (17%) Query: 220 TCNVLPRIKGLGYNCIQLMAI--------MEHAYYASFGYQITSFFAASSRYGT-PE--- 267 T L IK LG +QLM + ++ ++GY + A Y T P+ Sbjct: 260 TLTGLSYIKQLGVTHVQLMPVQDFEGVDELQPLKMYNWGYNTVHYNAPEGSYATDPDDPY 319 Query: 268 ----ELQELVDTAHSMGIIVLLDVVHSHASKNSADGLN------MFDGTDSCYFHSGPRG 317 EL+ + GI V+LDVV++H F + Y +G Sbjct: 320 ARIIELKRAIRAFQQEGIRVILDVVYNHVYVRETSSFEHLVPGYYFRYERNGYPSNGTGV 379 Query: 318 THDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFD 357 +DL R + +F++ ++ +WL+EY DGFRFD Sbjct: 380 GNDLASERKM------VKKFIIDSVTYWLKEYGVDGFRFD 413 >5M99-B nrPDB Length = 505 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 51/215 (23%), Positives = 83/215 (38%), Gaps = 43/215 (20%) Query: 227 IKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLD 286 ++ LG + + M E Y GY IT ++ YGT E+L+ ++ H GI V++D Sbjct: 36 LRKLGIDAVWFMPFNEAVSYH--GYDITDYYNVEKDYGTMEDLENMIQVLHENGIKVIMD 93 Query: 287 VVHSHASKNSADGLNMFDGTDSCYF----------HSGPRGTH--------DLWDSRLFA 328 +V +H S + + T S + HSG H +W LF Sbjct: 94 LVINHTSDEHPWFKDAVENTTSSPYWDYYIMSLEDHSGQDHWHWKINSKGQKVWYFGLFG 153 Query: 329 YS-------SWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYF 381 Y+ S ++ + + +W+ + DGFR D + G S +Y E+F Sbjct: 154 YNMPDLNHDSQKVREEVKKIVDFWISK-GVDGFRIDAAKHIYGWSWDDGIQESAEYFEWF 212 Query: 382 GLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSG 416 V + PD+I + E SG Sbjct: 213 ---------------RDYVLSKKPDAILVGEVFSG 232 >3DHU-A nrPDB Length = 449 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 27/79 (34%), Positives = 42/79 (53%), Gaps = 5/79 (6%) Query: 224 LPRIKGLGYNCIQLMAIM---EHAYYASFG--YQITSFFAASSRYGTPEELQELVDTAHS 278 L RIK LG + + L+ I E + G Y I + + YGT + + L D AH Sbjct: 36 LQRIKDLGTDILWLLPINPIGEVNRKGTLGSPYAIKDYRGINPEYGTLADFKALTDRAHE 95 Query: 279 MGIIVLLDVVHSHASKNSA 297 +G+ V+LD+V++H S +S Sbjct: 96 LGMKVMLDIVYNHTSPDSV 114 >5BRQ-A nrPDB Length = 568 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 24/70 (34%), Positives = 39/70 (55%), Gaps = 1/70 (1%) Query: 224 LPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIV 283 L IK L + I L I + + GY I+ +++ YGT + +EL++ AH GI V Sbjct: 46 LDYIKELACDVIWLTPIYQSPQNDN-GYDISDYYSIHEEYGTMADFEELLEEAHKRGIKV 104 Query: 284 LLDVVHSHAS 293 ++D+V +H S Sbjct: 105 IMDLVVNHTS 114 >1SMA-A nrPDB Length = 588 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 41/151 (27%), Positives = 62/151 (41%), Gaps = 27/151 (17%) Query: 227 IKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLD 286 + LG I L I ++ Y +F +G E L+ LV H GI V+LD Sbjct: 185 LADLGITGIYLTPIFRAP--SNHKYDTADYFEIDPHFGDKETLKTLVKRCHEKGIRVMLD 242 Query: 287 VVHSHASKNSADGLNMF-DGTDSCY---FH-------SGPRGTHDLWDSRLFAY------ 329 V +H A ++ +G S Y FH + PR +D FA+ Sbjct: 243 AVFNHCGYEFAPFQDVLKNGAASRYKDWFHIREFPLQTEPRPNYDT-----FAFVPHMPK 297 Query: 330 ---SSWEILRFLLSNIRWWLEEYRFDGFRFD 357 + E+ R+LL +W+ E+ DG+R D Sbjct: 298 LNTAHPEVKRYLLDVATYWIREFDIDGWRLD 328 >4CGT-A nrPDB Length = 678 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 37/149 (24%), Positives = 65/149 (43%), Gaps = 22/149 (14%) Query: 232 YNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSH 291 + I + AY+ GY F + +GT + Q L+ TAH+ GI +++D +H Sbjct: 84 FATINYSGVTNTAYH---GYWARDFKKTNPYFGTMADFQNLITTAHAKGIKIVIDFAPNH 140 Query: 292 ASKNSADGLNMFDG----------TDSCYFHSG-------PRGTH-DLWDSRLFAYSSWE 333 S A+ ++D T+ + H+G G + +L+D F +++ Sbjct: 141 TSPADAENGRLYDNGTLVGGYTNDTNGYFHHNGGSDFSSLENGIYKNLYDLADFNHNNAT 200 Query: 334 ILRFLLSNIRWWLEEYRFDGFRFDGVTSM 362 I ++ I+ WL + DG R D V M Sbjct: 201 IDKYFKDAIKLWL-DMGVDGIRVDAVKHM 228 >6JEQ-A nrPDB Length = 675 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 85/343 (24%), Positives = 126/343 (36%), Gaps = 62/343 (18%) Query: 64 GGIDKFSRGYESFGVHRCAD-GGLYCKE------WAPGAEGVF--LTGDFNGWNPFSYPY 114 GGI F ++ V+ D G +Y E WAP A F L +G P Sbjct: 21 GGISVFDAKFDELYVYDGDDLGAVYAPEETRFRLWAPTASEAFVVLYETEDGMPVKELPM 80 Query: 115 KKLDYGKWELYIPPKQNKSVLVPHGSKLKVVITSKSGEILYRISPWAKYVVREGDNVN-Y 173 K+ G W L + +V + + E + P+AK V G Sbjct: 81 KRDVQGTWTLTVAEDCGGLFYT-----YRVKVGEQWNEA---VDPYAKAVGVNGTKTAIL 132 Query: 174 DWIHWDPEHSYEFKHSRP-KKPRSLRIYESHV---GISSHEGKVASYKHFTC-------- 221 D +PE +E P P IYE HV I G K Sbjct: 133 DLRSTNPE-GWENDQKPPLASPTDAVIYELHVRDLSIHPQSGIREKGKFLGLTEEGTRGP 191 Query: 222 NVLP----RIKGLGYNCIQLMAIMEHAYYA-----------SFGYQITSFFAASSRYGTP 266 N +P I GLG +QL+ I +++ + ++GY ++ Y T Sbjct: 192 NGIPTGLDHITGLGVTHVQLLPIYDYSQESVDESRLDEPHYNWGYDPQNYNVPEGSYSTD 251 Query: 267 E--------ELQELVDTAHSMGIIVLLDVVHSHASKNSADG-LNMFDGTDSCYF--HSGP 315 EL+ L+ H+ G+ V++DVV++H DG L F Y+ + Sbjct: 252 PHNPAARILELKRLIQKLHARGLRVIMDVVYNHVY----DGYLIHFTKLVPGYYLRYKAD 307 Query: 316 RGTHDLWDSRLFAYSSWEILR-FLLSNIRWWLEEYRFDGFRFD 357 R D S I+R +++ +I W+ EY DGFRFD Sbjct: 308 RTFSDGTFCGNECASERPIMRKYIIESILHWVREYHIDGFRFD 350 >2AAA-A nrPDB Length = 484 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 46/166 (27%), Positives = 69/166 (41%), Gaps = 36/166 (21%) Query: 224 LPRIKGLGYNCIQLMAIMEH---------AYYASFGYQITSFFAASSRYGTPEELQELVD 274 L I+G+G+ I + I E AY+ GY + +S +GT + L+ L D Sbjct: 49 LDYIEGMGFTAIWISPITEQLPQDTADGEAYH---GYWQQKIYDVNSNFGTADNLKSLSD 105 Query: 275 TAHSMGIIVLLDVVHSH----ASKNSADGLNMFDGTD-SCYFHSGPRGTHDLWDSRLFAY 329 H+ G+ +++DVV H + N D ++FD D S YFH P WD+ Sbjct: 106 ALHARGMYLMVDVVPDHMGYAGNGNDVD-YSVFDPFDSSSYFH--PYCLITDWDNLTMVE 162 Query: 330 SSWE--------ILRFLLSNIR--WW------LEEYRFDGFRFDGV 359 WE L + +R W+ + Y DG R D V Sbjct: 163 DCWEGDTIVSLPDLDTTETAVRTIWYDWVADLVSNYSVDGLRIDSV 208 >5ZCD-A nrPDB Length = 555 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 40/171 (23%), Positives = 71/171 (41%), Gaps = 35/171 (20%) Query: 224 LPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIV 283 L + LG + I + I + + GY I+ + +GT E+ EL+D H G+ + Sbjct: 37 LDYLSDLGIDVIWICPIYQSPNDDN-GYDISDYKDIMKDFGTMEDFDELLDEVHHRGMKL 95 Query: 284 LLDVVHSHASKNSADGLNMFDGTDSCY-----FHSGPRGTH-DLWDSRLFAYSSWE---- 333 ++D+V +H S L ++ Y +H G G + W+S +F+ S+WE Sbjct: 96 IMDLVINHTSDEHPWFLESRSAKENPYRDYYIWHEGKDGKEPNNWES-IFSGSAWEFDEK 154 Query: 334 ----------------------ILRFLLSNIRWWLEEYRFDGFRFDGVTSM 362 + L + WWL++ DGFR D ++ + Sbjct: 155 TKEYYMHVFSKKQPDLNWENEKVRHELYEMVNWWLDK-GIDGFRVDAISHI 204 >2ZE0-A nrPDB Length = 555 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 38/152 (25%), Positives = 64/152 (42%), Gaps = 42/152 (27%) Query: 247 ASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHA---------SKNSA 297 A GY I+ ++A +GT ++ EL+ AH G+ V+LD+V +H S++S Sbjct: 59 ADNGYDISDYYAIMDEFGTMDDFDELLAQAHRRGLKVILDLVINHTSDEHPWFIESRSSR 118 Query: 298 DGLNMFDGTDSCYFHSGPRGTH-DLWDSRLFAYSSW------------------------ 332 D D + G G + W+S +F S+W Sbjct: 119 DNPK----RDWYIWRDGKDGREPNNWES-IFGGSAWQYDERTGQYYLHIFDVKQPDLNWE 173 Query: 333 --EILRFLLSNIRWWLEEYRFDGFRFDGVTSM 362 E+ + L + WWL++ DGFR D ++ + Sbjct: 174 NSEVRQALYEMVNWWLDK-GIDGFRIDAISHI 204 >1EA9-C nrPDB Length = 583 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 39/152 (25%), Positives = 66/152 (43%), Gaps = 22/152 (14%) Query: 224 LPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIV 283 L + LG N + + + + Y +F ++G + L++LVD H GI V Sbjct: 178 LDHLSKLGVNAVYFTPLFKAT--TNHKYDTEDYFQIDPQFGDKDTLKKLVDLCHERGIRV 235 Query: 284 LLDVVHSHASKNSADGLNMF-DGTDSCY---FH--SGPRGTHD---LWDSRLFAYSSW-- 332 LLD V +H+ + +++ +G S Y FH S P D +D+ FA+ Sbjct: 236 LLDAVFNHSGRTFPPFVDVLKNGEKSKYKDWFHIRSLPLEVVDGIPTYDT--FAFEPLMP 293 Query: 333 -------EILRFLLSNIRWWLEEYRFDGFRFD 357 ++ +LL +W+ E DG+R D Sbjct: 294 KLNTEHPDVKEYLLKAAEYWIRETGIDGWRLD 325 >4LXF-A nrPDB Length = 620 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 22/69 (31%), Positives = 36/69 (52%), Gaps = 1/69 (1%) Query: 227 IKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLD 286 ++ LG +CI L + GY I F+ +GT ++ LVD AH GI ++ D Sbjct: 97 LQWLGIDCIWLPPFYDSPLRDG-GYDIRDFYKVLPEFGTVDDFVALVDAAHRRGIRIITD 155 Query: 287 VVHSHASKN 295 +V +H S++ Sbjct: 156 LVMNHTSES 164 >1V3M-A nrPDB Length = 686 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 41/159 (25%), Positives = 67/159 (42%), Gaps = 32/159 (20%) Query: 232 YNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSH 291 Y+ I + AY+ GY F + YGT ++ + L+DTAH+ I V++D +H Sbjct: 84 YSVINYSGVNNTAYH---GYWARDFKKTNPAYGTMQDFKNLIDTAHAHNIKVIIDFAPNH 140 Query: 292 ASKNSA------------DGLNMFDG----TDSCYFHSGPRGT----------HDLWDSR 325 S S+ D N+ G T + + H G GT +L+D Sbjct: 141 TSPASSDDPSFAENGRLYDNGNLLGGYTNDTQNLFHHYG--GTDFSTIENGIYKNLYDLA 198 Query: 326 LFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLY 364 +++ + +L I+ WL + DG R D V M + Sbjct: 199 DLNHNNSSVDVYLKDAIKMWL-DLGVDGIRVDAVKHMPF 236 >1LWJ-A nrPDB Length = 441 Score = 42.7 bits (99), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 20/71 (28%), Positives = 37/71 (52%), Gaps = 2/71 (2%) Query: 222 NVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGI 281 N + +K LG + + LM + + GY + F++ + YG+ E +E+++ H GI Sbjct: 27 NAVSYLKELGIDFVWLMPVFSSISFH--GYDVVDFYSFKAEYGSEREFKEMIEAFHDSGI 84 Query: 282 IVLLDVVHSHA 292 V+LD+ H Sbjct: 85 KVVLDLPIHHT 95 >3ZO9-A nrPDB Length = 593 Score = 42.4 bits (98), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 22/67 (32%), Positives = 34/67 (50%), Gaps = 1/67 (1%) Query: 227 IKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLD 286 IK LG +C+ L + GY I F+ +GT ++ L+D AH GI ++ D Sbjct: 70 IKWLGVDCLWLPPFYDSPLRDG-GYDIRDFYKVLPEFGTVDDFVTLLDAAHRRGIRIITD 128 Query: 287 VVHSHAS 293 +V +H S Sbjct: 129 LVMNHTS 135 >5WCZ-A nrPDB Length = 586 Score = 42.0 bits (97), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 22/74 (29%), Positives = 40/74 (54%), Gaps = 1/74 (1%) Query: 224 LPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIV 283 L IK LG + I L + + + GY I+ + ++GT E++ +L+D H G+ + Sbjct: 61 LDYIKNLGADVIWLSPVFDSPQDDN-GYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKI 119 Query: 284 LLDVVHSHASKNSA 297 ++D+V +H S A Sbjct: 120 VMDLVVNHTSDEHA 133 >5OT1-A nrPDB Length = 765 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 36/152 (23%), Positives = 66/152 (43%), Gaps = 18/152 (11%) Query: 227 IKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLD 286 ++ LG I + I ++ GY ++ ++GT +EL+E +D AH G+ V+ D Sbjct: 361 LQSLGVTIIYINPIFLSG--SAHGYDTYDYYRLDPKFGTEDELREFLDEAHRRGMRVIFD 418 Query: 287 VVHSHASKNSADGLNMFD-GTDSCY----------FHSGPRGTHDLW----DSRLFAYSS 331 V +H + L++++ G +S Y F G + W ++ Sbjct: 419 FVPNHCGIGNPAFLDVWEKGNESPYWDWFFVKKWPFKLGDGSAYVGWWGFGSLPKLNTAN 478 Query: 332 WEILRFLLSNIRWWLEEYRFDGFRFDGVTSML 363 E+ +L+ W+ E+ FDG R D +L Sbjct: 479 QEVREYLIGAALHWI-EFGFDGIRVDVPNEVL 509 >3WY1-A nrPDB Length = 538 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 17/45 (37%), Positives = 29/45 (64%) Query: 249 FGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHAS 293 FGY ++ + +GT E+ + L++ AHS+G+ V++D V SH S Sbjct: 63 FGYDVSDYRDVDPMFGTLEDFKALLEKAHSLGLKVMIDQVISHTS 107 >1BF2-A nrPDB Length = 750 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 30/128 (23%), Positives = 58/128 (45%), Gaps = 19/128 (14%) Query: 249 FGYQITSFFAASSRY-------GTPEELQELVDTAHSMGIIVLLDVVHSHASK----NSA 297 +GY ++F+ RY G E Q +V H+ GI V +DVV++H ++ S+ Sbjct: 248 WGYMTENYFSPDRRYAYNKAAGGPTAEFQAMVQAFHNAGIKVYMDVVYNHTAEGGTWTSS 307 Query: 298 DGLNM----FDGTDSCYFHSGPRGTHDLWDSRLFA--YSSWEIL--RFLLSNIRWWLEEY 349 D + G D+ ++ G +D+ ++++ + ++ ++ +W Sbjct: 308 DPTTATIYSWRGLDNATYYELTSGNQYFYDNTGIGANFNTYNTVAQNLIVDSLAYWANTM 367 Query: 350 RFDGFRFD 357 DGFRFD Sbjct: 368 GVDGFRFD 375 >3EDF-A nrPDB Length = 601 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 25/77 (32%), Positives = 38/77 (49%), Gaps = 2/77 (2%) Query: 220 TCNVLPRIKGLGYNCIQLMAIMEH--AYYASFGYQITSFFAASSRYGTPEELQELVDTAH 277 T + L I GLG+ + ++E+ A Y+ GY T + RYG+ E+ L A Sbjct: 150 TIDHLDYIAGLGFTQLWPTPLVENDAAAYSYHGYAATDHYRIDPRYGSNEDFVRLSTEAR 209 Query: 278 SMGIIVLLDVVHSHASK 294 G+ ++ DVV SH K Sbjct: 210 KRGMGLIQDVVLSHIGK 226 >3VM7-A nrPDB Length = 492 Score = 39.7 bits (91), Expect = 0.005, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 41/75 (54%), Gaps = 9/75 (12%) Query: 224 LPRIKGLGYNCIQLMAIMEH-------AYYASFGYQITSFFAASSRYGTPEELQELVDTA 276 L I+G+G++ + + I + A Y GY T +A + +GT E+L+ L D Sbjct: 70 LDYIQGMGFDSVWISPITKQFEDDWNGAPY--HGYWQTDLYALNEHFGTEEDLRALADEL 127 Query: 277 HSMGIIVLLDVVHSH 291 H+ G+ +++DVV +H Sbjct: 128 HARGMFLMVDVVINH 142 >2WC7-A nrPDB Length = 488 Score = 39.7 bits (91), Expect = 0.005, Method: Compositional matrix adjust. Identities = 30/112 (26%), Positives = 48/112 (42%), Gaps = 6/112 (5%) Query: 187 KHSRPKKPRSLRIYESHVGISSHEGKVASYKHF----TCNVLPRIKGLGYNCIQLMAIME 242 + +R K+PR + E+ + YK L I+ LG N I I + Sbjct: 21 RFARSKQPRKRLLQEARWEDWDSMPTLQGYKGGDLWGIMEDLDYIQNLGINAIYFTPIFQ 80 Query: 243 HAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASK 294 A ++ Y ++ G E +EL+D AH I V+LD V +H+S+ Sbjct: 81 SA--SNHRYHTHDYYQVDPMLGGNEAFKELLDAAHQRNIKVVLDGVFNHSSR 130 >1CYG-A nrPDB Length = 680 Score = 38.5 bits (88), Expect = 0.010, Method: Compositional matrix adjust. Identities = 35/137 (25%), Positives = 53/137 (38%), Gaps = 25/137 (18%) Query: 250 GYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADG---------- 299 GY F + +GT + Q LVD AH+ GI V++D +H S S Sbjct: 95 GYWARDFKKPNPFFGTLSDFQRLVDAAHAKGIKVIIDFAPNHTSPASETNPSYMENGRLY 154 Query: 300 -----LNMFDGTDSCYFHSGPRGT---------HDLWDSRLFAYSSWEILRFLLSNIRWW 345 L + + YFH T +L+D + + I R+L ++ W Sbjct: 155 DNGTLLGGYTNDANMYFHHNGGTTFSSLEDGIYRNLFDLADLNHQNPVIDRYLKDAVKMW 214 Query: 346 LEEYRFDGFRFDGVTSM 362 + + DG R D V M Sbjct: 215 I-DMGIDGIRMDAVKHM 230 >2TAA-A nrPDB Length = 478 Score = 37.7 bits (86), Expect = 0.016, Method: Compositional matrix adjust. Identities = 22/80 (27%), Positives = 41/80 (51%), Gaps = 6/80 (7%) Query: 224 LPRIKGLGYNCIQLMAIMEH-----AYYASF-GYQITSFFAASSRYGTPEELQELVDTAH 277 L I+G+G+ I + + AY ++ GY T ++ + YGT ++L+ L H Sbjct: 49 LDYIQGMGFTAIWITPVTAQLPQDCAYGDAYTGYWQTDIYSLNENYGTADDLKALSSALH 108 Query: 278 SMGIIVLLDVVHSHASKNSA 297 G+ +++DVV +H + A Sbjct: 109 ERGMYLMVDVVANHMGYDGA 128 >1MXD-A nrPDB Length = 435 Score = 37.4 bits (85), Expect = 0.020, Method: Compositional matrix adjust. Identities = 16/34 (47%), Positives = 23/34 (67%) Query: 258 AASSRYGTPEELQELVDTAHSMGIIVLLDVVHSH 291 +R+G+ EEL L+ TAH+ GI V+ DVV +H Sbjct: 78 TVETRFGSKEELVRLIQTAHAYGIKVIADVVINH 111 >1UOK-A nrPDB Length = 558 Score = 37.4 bits (85), Expect = 0.025, Method: Compositional matrix adjust. Identities = 42/175 (24%), Positives = 67/175 (38%), Gaps = 47/175 (26%) Query: 224 LPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIV 283 L +K LG + I L + E + GY I+ + + +GT E+ EL+ H + + Sbjct: 37 LDYLKELGIDVIWLSPVYESPNDDN-GYDISDYCKIMNEFGTMEDWDELLHEMHERNMKL 95 Query: 284 LLDVVHSHA---------SKNSADGL--------------------NMFDG--------T 306 ++D+V +H S+ S D F G T Sbjct: 96 MMDLVVNHTSDEHNWFIESRKSKDNKYRDYYIWRPGKEGKEPNNWGAAFSGSAWQYDEMT 155 Query: 307 DSCYFHSGPRGTHDL-WDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVT 360 D Y H + DL WD+ +E+++F WLE+ DGFR D + Sbjct: 156 DEYYLHLFSKKQPDLNWDNEKVRQDVYEMMKF-------WLEK-GIDGFRMDVIN 202 >1IV8-A nrPDB Length = 720 Score = 37.0 bits (84), Expect = 0.029, Method: Compositional matrix adjust. Identities = 18/71 (25%), Positives = 40/71 (56%) Query: 228 KGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDV 287 K LG + + L ++ + ++ GY + + G +E + L++TAH++G+ ++ D+ Sbjct: 27 KDLGVSHLYLSPVLMASPGSNHGYDVIDHSRINDELGGEKEYRRLIETAHTIGLGIIQDI 86 Query: 288 VHSHASKNSAD 298 V +H + NS + Sbjct: 87 VPNHMAVNSLN 97 >2Z1K-A nrPDB Length = 475 Score = 37.0 bits (84), Expect = 0.033, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 34/72 (47%), Gaps = 2/72 (2%) Query: 224 LPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIV 283 LP + LG I L + A A+ Y +F G E L+ L++ AH+ G+ V Sbjct: 56 LPYLLDLGVEAIYLNPVF--ASTANHRYHTVDYFQVDPILGGNEALRHLLEVAHAHGVRV 113 Query: 284 LLDVVHSHASKN 295 +LD V +H + Sbjct: 114 ILDGVFNHTGRG 125 >1EO7-A nrPDB Length = 686 Score = 36.6 bits (83), Expect = 0.034, Method: Compositional matrix adjust. Identities = 21/67 (31%), Positives = 32/67 (47%), Gaps = 3/67 (4%) Query: 232 YNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSH 291 Y+ I + AY+ GY F + YGT + Q L+ AH+ I V++D +H Sbjct: 84 YSIINYSGVNNTAYH---GYWARDFKKTNPAYGTIADFQNLIAAAHAKNIKVIIDFAPNH 140 Query: 292 ASKNSAD 298 S S+D Sbjct: 141 TSPASSD 147 >5X7U-A nrPDB Length = 549 Score = 36.6 bits (83), Expect = 0.039, Method: Compositional matrix adjust. Identities = 23/71 (32%), Positives = 37/71 (52%), Gaps = 9/71 (12%) Query: 227 IKGLGYNCIQLMAIMEHAYYASF----GYQITSFFAASSRYGTPEELQELVDTAHSMGII 282 I+ LG I L+ +YAS GY I+ + + +GT E+ + +D AH GI Sbjct: 42 IESLGVTAIWLLP-----FYASPLKDGGYDISDYRSLHPDFGTIEDFKVFLDEAHRRGIR 96 Query: 283 VLLDVVHSHAS 293 V+ ++V +H S Sbjct: 97 VITELVLNHTS 107 >3WN6-A nrPDB Length = 404 Score = 36.6 bits (83), Expect = 0.042, Method: Compositional matrix adjust. Identities = 16/55 (29%), Positives = 29/55 (52%), Gaps = 5/55 (9%) Query: 260 SSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSG 314 +S+YG +L+ L++ H G+ V+ D+V +H + DG ++ C F G Sbjct: 62 ASKYGNEAQLKSLIEAFHGKGVQVIADIVINHRTAEHKDGRGIY-----CLFEGG 111 >1JL8-A nrPDB Length = 585 Score = 36.6 bits (83), Expect = 0.042, Method: Compositional matrix adjust. Identities = 21/69 (30%), Positives = 32/69 (46%), Gaps = 2/69 (2%) Query: 224 LPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIV 283 LP ++ LG + I A + Y + A ++G + LVD AH GI + Sbjct: 179 LPYLEELGVTALYFTPIF--ASPSHHKYDTADYLAIDPQFGDLPTFRRLVDEAHRRGIKI 236 Query: 284 LLDVVHSHA 292 +LD V +HA Sbjct: 237 ILDAVFNHA 245 >4AIE-A nrPDB Length = 549 Score = 36.6 bits (83), Expect = 0.042, Method: Compositional matrix adjust. Identities = 23/87 (26%), Positives = 42/87 (48%), Gaps = 1/87 (1%) Query: 224 LPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIV 283 L ++ LG + I L + + + GY I+ + A +YGT ++ EL+ A I + Sbjct: 38 LDYLEKLGIDAIWLSPVYQSPGVDN-GYDISDYEAIDPQYGTMADMDELISKAKEHHIKI 96 Query: 284 LLDVVHSHASKNSADGLNMFDGTDSCY 310 ++D+V +H S + G D+ Y Sbjct: 97 VMDLVVNHTSDQHKWFVEAKKGKDNQY 123 >1AVA-A nrPDB Length = 403 Score = 36.2 bits (82), Expect = 0.053, Method: Compositional matrix adjust. Identities = 27/124 (21%), Positives = 48/124 (38%), Gaps = 31/124 (25%) Query: 260 SSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTH 319 +S+YG +L+ L+ H G+ + D+V +H + DG ++ C F G Sbjct: 61 ASKYGNKAQLKSLIGALHGKGVKAIADIVINHRTAEHKDGRGIY-----CIFEGGTPDAR 115 Query: 320 DLW-------DSRLFA-------------------YSSWEILRFLLSNIRWWLEEYRFDG 353 W D R +A + + + + L+ + W + FDG Sbjct: 116 LDWGPHMICRDDRPYADGTGNPDTGADFGAAPDIDHLNLRVQKELVEWLNWLKADIGFDG 175 Query: 354 FRFD 357 +RFD Sbjct: 176 WRFD 179 >3K8L-A nrPDB Length = 669 Score = 35.8 bits (81), Expect = 0.074, Method: Compositional matrix adjust. Identities = 21/69 (30%), Positives = 32/69 (46%), Gaps = 2/69 (2%) Query: 224 LPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIV 283 L + LG + L I H + GY +T + + + GT + LV AH+ GI + Sbjct: 66 LDYLNQLGVKALWLSPI--HPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKI 123 Query: 284 LLDVVHSHA 292 LD V +H Sbjct: 124 YLDYVMNHT 132 >1GJU-A nrPDB Length = 637 Score = 35.4 bits (80), Expect = 0.077, Method: Compositional matrix adjust. Identities = 23/87 (26%), Positives = 39/87 (44%), Gaps = 13/87 (14%) Query: 223 VLPRIKGLGYNCIQLMAIMEHAYYASFG-----YQITSFFAASSRYGTP--------EEL 269 +LP +K LG + I L+ + + G Y + + RY P EE Sbjct: 125 LLPFVKSLGADAIYLLPVSRMSDLFKKGDAPSPYSVKNPMELDERYHDPLLEPFKVDEEF 184 Query: 270 QELVDTAHSMGIIVLLDVVHSHASKNS 296 + V+ H +GI V+LD + A+++S Sbjct: 185 KAFVEACHILGIRVILDFIPRTAARDS 211 >3QGV-A nrPDB Length = 435 Score = 35.4 bits (80), Expect = 0.083, Method: Compositional matrix adjust. Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 9/53 (16%) Query: 248 SFGYQITSFF---------AASSRYGTPEELQELVDTAHSMGIIVLLDVVHSH 291 S GY FF +R+G+ +EL +++TAH+ G+ V+ D+V +H Sbjct: 59 SMGYDPYDFFDLGEYDQKGTVETRFGSKQELVNMINTAHAYGMKVIADIVINH 111 >4GI8-A nrPDB Length = 557 Score = 35.4 bits (80), Expect = 0.084, Method: Compositional matrix adjust. Identities = 23/74 (31%), Positives = 38/74 (51%), Gaps = 9/74 (12%) Query: 224 LPRIKGLGYNCIQLMAIMEHAYYAS----FGYQITSFFAASSRYGTPEELQELVDTAHSM 279 L +KGLG + I + + +YAS GY I+ + YGT E+ L+ Sbjct: 38 LDYLKGLGIDAIWI-----NPHYASPNTDNGYDISDYREVMKEYGTMEDFDRLMAELKKR 92 Query: 280 GIIVLLDVVHSHAS 293 G+ +++DVV +H+S Sbjct: 93 GMRLMVDVVINHSS 106 >2DIE-A nrPDB Length = 485 Score = 35.4 bits (80), Expect = 0.091, Method: Compositional matrix adjust. Identities = 37/145 (25%), Positives = 60/145 (41%), Gaps = 24/145 (16%) Query: 261 SRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHD 320 ++YGT +LQ V + + GI V DVV +H K ADG M + + R + Sbjct: 77 TKYGTRSQLQGAVTSLKNNGIQVYGDVVMNH--KGGADGTEMVNAVEVN------RSNRN 128 Query: 321 LWDSRLFAYSSWEILRF-----LLSNIRWWLEEYRFDGFRFD---GVTSMLYHHHGVGQG 372 S + +W F SN +W Y FDG +D + + +Y G G+ Sbjct: 129 QEISGEYTIEAWTKFDFPGRGNTHSNFKW--RWYHFDGTDWDQSRQLQNKIYKFRGTGKA 186 Query: 373 FSGDYSEYFGLQVDEDALTYLMLAN 397 + + + ++ YLM A+ Sbjct: 187 WD------WEVDIENGNYDYLMYAD 205 >3UER-A nrPDB Length = 655 Score = 35.0 bits (79), Expect = 0.10, Method: Compositional matrix adjust. Identities = 34/142 (23%), Positives = 55/142 (38%), Gaps = 4/142 (2%) Query: 177 HWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQ 236 H P +R +P L+ E VG ++ + A L ++GLG + Sbjct: 71 HARPAELRRLDEARLLRPDWLQRPEM-VGYVAYTDRFAGTLKGVEERLDYLEGLGVKYLH 129 Query: 237 LMAIME-HAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKN 295 LM ++ GY + + A GT ++L L GI ++LD+V +H ++ Sbjct: 130 LMPLLRPREGENDGGYAVQDYRAVRPDLGTMDDLSALARALRGRGISLVLDLVLNHVARE 189 Query: 296 S--ADGLNMFDGTDSCYFHSGP 315 A D YFH P Sbjct: 190 HAWAQKARAGDPKYRAYFHLFP 211 >3AXH-A nrPDB Length = 589 Score = 34.7 bits (78), Expect = 0.13, Method: Compositional matrix adjust. Identities = 20/70 (28%), Positives = 33/70 (47%), Gaps = 1/70 (1%) Query: 224 LPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIV 283 L IK LG + I + + GY I ++ YGT E+ L++ H +G+ Sbjct: 46 LEYIKELGADAIWISPFYDSPQ-DDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKF 104 Query: 284 LLDVVHSHAS 293 + D+V +H S Sbjct: 105 ITDLVINHCS 114 >5YKB-A nrPDB Length = 571 Score = 34.7 bits (78), Expect = 0.14, Method: Compositional matrix adjust. Identities = 73/377 (19%), Positives = 139/377 (36%), Gaps = 78/377 (20%) Query: 227 IKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLD 286 +K LG +C+ L+ GY + + GT ++ + + AH+ G+ V+ D Sbjct: 45 LKNLGVDCLWLLPWFPSPLRDD-GYDVADYRGIHPDLGTLDDFKVFLREAHARGLWVIGD 103 Query: 287 VVHSHASKN------SADGLNMFDGTDSCYFHSGPRGTHD--LWDSRLFAYSSWEILRFL 338 +V +H S + + G + DG+ + Y HD +W Y+ I+ Sbjct: 104 LVTNHTSSDHPWFQAARRGPTLPDGSPNEY--------HDYYVWSDEGKEYADTRIIFTD 155 Query: 339 LSNIRWWLEE-------YRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDE---D 388 W L+E +RF F + Y + V + G + L +D D Sbjct: 156 TEVSNWTLDEQAGKYYWHRF----FASQPDLNYDNPKVVEELHGAARFWLDLGLDGFRVD 211 Query: 389 ALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLK 448 A+ YL+ T C + E + G A+ G RL +A +W + + Sbjct: 212 AVPYLI---EREGTSCENLPETHEILKGFRAMVDREYPG------RLLLAEAFQWPEEVV 262 Query: 449 EF--------------------------KDEDWNMGDIVYTLTNRRYLEKCIAYAESHDQ 482 E+ +++ ++ +I+ L + + +HD+ Sbjct: 263 EYFGTEAEPEFHMCFNFPVMPRLYMSLKREDTSSIREIMGRLPKIPSFGQWCIFLRNHDE 322 Query: 483 ---ALVGDKSLAF----WLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGY 535 +V D AF + DA M N+ + P++D + +++ + L G Sbjct: 323 LTLEMVTDDERAFMYAAYAPDARMKINVGIRRRLAPLLDNDRRRIELLNTVLLALPGSPV 382 Query: 536 LNF-----MGNEFGHPE 547 L + MG++ G P+ Sbjct: 383 LYYGDEIGMGDDLGLPD 399 >4J3X-A nrPDB Length = 905 Score = 34.3 bits (77), Expect = 0.21, Method: Compositional matrix adjust. Identities = 24/95 (25%), Positives = 50/95 (52%), Gaps = 7/95 (7%) Query: 268 ELQELVDTAHSMGIIVLLDVVHSHASKNSADGLN-MFDGTDSCYFHSGPRGTH-DLWDSR 325 E +++V + +G+ V++DVV++H + G++ + D Y+ R T+ + +S Sbjct: 401 EYRQMVQALNRIGLRVVMDVVYNHLDSSGPCGISSVLDKIVPGYYVR--RDTNGQIENSA 458 Query: 326 LFAYSSWE---ILRFLLSNIRWWLEEYRFDGFRFD 357 ++ E + R ++ ++ W Y+ DGFRFD Sbjct: 459 AMNNTASEHFMVDRLIVDDLLNWAVNYKVDGFRFD 493 >1A47-A nrPDB Length = 683 Score = 33.1 bits (74), Expect = 0.38, Method: Compositional matrix adjust. Identities = 41/173 (23%), Positives = 68/173 (39%), Gaps = 40/173 (23%) Query: 227 IKGLGYNCIQLMAIMEHAYY----ASFG-------YQITSFFAASSRYGTPEELQELVDT 275 + G+G I + +E+ Y ++FG Y F + +G+ + Q L++T Sbjct: 66 LTGMGVTAIWISQPVENIYAVLPDSTFGGSTSYHGYWARDFKRTNPYFGSFTDFQNLINT 125 Query: 276 AHSMGIIVLLDVVHSHASKNS------ADGLNMFD--------------------GTDSC 309 AH+ I V++D +H S S A+ ++D GTD Sbjct: 126 AHAHNIKVIIDFAPNHTSPASETDPTYAENGRLYDNGTLLGGYTNDTNGYFHHYGGTDFS 185 Query: 310 YFHSGPRGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSM 362 + G +L+D + I +L S I+ WL + DG R D V M Sbjct: 186 SYEDGIY--RNLFDLADLNQQNSTIDSYLKSAIKVWL-DMGIDGIRLDAVKHM 235 >4JCM-A nrPDB Length = 702 Score = 33.1 bits (74), Expect = 0.47, Method: Compositional matrix adjust. Identities = 39/134 (29%), Positives = 59/134 (44%), Gaps = 25/134 (18%) Query: 250 GYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKN-------------- 295 GY F + +G ++ L++TAH+ I V++D V +H S Sbjct: 124 GYWARDFKKTNPFFGDFDDFSRLIETAHAHDIKVVIDFVPNHTSPVDIEDGALYDNGTLL 183 Query: 296 ---SADGLNMF---DGTD-SCYFHSGPRGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEE 348 S D N F G+D S Y +S R +DL + L S+ I ++L +I+ WL+ Sbjct: 184 GHYSTDANNYFYNYGGSDFSDYENSIYRNLYDL--ASLNQQHSF-IDKYLKESIQLWLDT 240 Query: 349 YRFDGFRFDGVTSM 362 DG R D V M Sbjct: 241 -GIDGIRVDAVAHM 253 >1QHO-A nrPDB Length = 686 Score = 32.7 bits (73), Expect = 0.52, Method: Compositional matrix adjust. Identities = 32/125 (25%), Positives = 46/125 (36%), Gaps = 25/125 (20%) Query: 224 LPRIKGLGYNCIQLMAIMEHAYYAS-------FGYQITSFFAASSRYGTPEELQELVDTA 276 LP +K LG I L ++++ + GY F +G LV+ A Sbjct: 58 LPYLKQLGVTTIWLSPVLDNLDTLAGTDNTGYHGYWTRDFKQIEEHFGNWTTFDTLVNDA 117 Query: 277 HSMGIIVLLDVVHSHASKNSADGL----------------NMFDGTDSCYFHSGPRGTHD 320 H GI V++D V +H++ A+ N FD YFH G Sbjct: 118 HQNGIKVIVDFVPNHSTPFKANDSTFAEGGALYNNGTYMGNYFDDATKGYFHH--NGDIS 175 Query: 321 LWDSR 325 WD R Sbjct: 176 NWDDR 180 >4UZU-A nrPDB Length = 513 Score = 32.7 bits (73), Expect = 0.54, Method: Compositional matrix adjust. Identities = 22/96 (22%), Positives = 36/96 (37%), Gaps = 11/96 (11%) Query: 221 CNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFF---------AASSRYGTPEELQE 271 N + LG + L + + GY + + ++YGT + + Sbjct: 27 ANEANNLSSLGITALWLPPAYKGTSRSDVGYGVYDLYDLGEFNQKGTVRTKYGTKAQYLQ 86 Query: 272 LVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTD 307 + AH+ G+ V DVV H K ADG D + Sbjct: 87 AIQAAHAAGMQVYADVVFDH--KGGADGTEWVDAVE 120 >4AEF-A nrPDB Length = 645 Score = 32.7 bits (73), Expect = 0.62, Method: Compositional matrix adjust. Identities = 21/64 (32%), Positives = 26/64 (40%), Gaps = 2/64 (3%) Query: 230 LGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVH 289 LG N I L I Y GY I +F + R G +L+ I V+LD V Sbjct: 251 LGINAIYLTPIFSSLTYH--GYDIVDYFHVARRLGGDRAFVDLLSELKRFDIKVILDGVF 308 Query: 290 SHAS 293 H S Sbjct: 309 HHTS 312 >3BH4-A nrPDB Length = 483 Score = 32.3 bits (72), Expect = 0.64, Method: Compositional matrix adjust. Identities = 36/145 (24%), Positives = 59/145 (40%), Gaps = 25/145 (17%) Query: 261 SRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHD 320 ++YGT ELQ+ + + HS + V DVV +H + G + + + + R Sbjct: 73 TKYGTKSELQDAIGSLHSRNVQVYGDVVLNHKA-----GADATEDVTAVEVNPANRNQE- 126 Query: 321 LWDSRLFAYSSWEILRF-----LLSNIRW-WLEEYRFDGFRFDGV--TSMLYHHHGVGQG 372 S + +W RF S+ +W W Y FDG +D S ++ G G+ Sbjct: 127 --TSEEYQIKAWTDFRFPGRGNTYSDFKWHW---YHFDGADWDESRKISRIFKFRGEGKA 181 Query: 373 FSGDYSEYFGLQVDEDALTYLMLAN 397 + + S G YLM A+ Sbjct: 182 WDWEVSSENG------NYDYLMYAD 200 >1E3X-A nrPDB Length = 483 Score = 32.0 bits (71), Expect = 0.85, Method: Compositional matrix adjust. Identities = 27/103 (26%), Positives = 44/103 (42%), Gaps = 17/103 (16%) Query: 261 SRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHD 320 ++YGT ELQ+ + + HS + V DVV +H + G + + + + R Sbjct: 73 TKYGTKSELQDAIGSLHSRNVQVYGDVVLNHKA-----GADATEDVTAVEVNPANRNQE- 126 Query: 321 LWDSRLFAYSSWEILRF-----LLSNIRW-WLEEYRFDGFRFD 357 S + +W RF S+ +W W Y FDG +D Sbjct: 127 --TSEEYQIKAWTDFRFPGRGNTYSDFKWHW---YHFDGADWD 164 >3HJE-A nrPDB Length = 704 Score = 32.0 bits (71), Expect = 0.88, Method: Compositional matrix adjust. Identities = 16/64 (25%), Positives = 32/64 (50%) Query: 230 LGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVH 289 LG + L +++ ++ GY + + + G EE L+D A S G+ ++ D+V Sbjct: 27 LGVTHLYLSPVLKARPGSTHGYDVVDYNTINDELGGEEEYIRLIDEAKSKGLGIIQDIVP 86 Query: 290 SHAS 293 +H + Sbjct: 87 NHMA 90 >3BSH-A nrPDB Length = 414 Score = 32.0 bits (71), Expect = 0.91, Method: Compositional matrix adjust. Identities = 15/55 (27%), Positives = 26/55 (47%), Gaps = 5/55 (9%) Query: 260 SSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSG 314 +S+YG EL+ L+ H G+ + D+V +H + D + +C F G Sbjct: 62 ASKYGNAAELKSLIGALHGKGVQAIADIVINHRCADYKDSRGI-----ACIFEGG 111 >3T99-A nrPDB Length = 334 Score = 32.0 bits (71), Expect = 1.0, Method: Compositional matrix adjust. Identities = 23/99 (23%), Positives = 49/99 (49%), Gaps = 9/99 (9%) Query: 453 EDWNMGDIVYTLTNRRY-LEKCIAYAESHDQALVGDKSLAFWLMD-AEMYTNMS---VLT 507 E+W + D + + ++ + L+K +AYA+ + ++ D ++ + + D E+Y+ + +L Sbjct: 57 ENWPLCDCLISFHSKGFPLDKAVAYAKLRNPFVINDLNMQYLIQDRREVYSILQAEGILL 116 Query: 508 PFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHP 546 P +++R K LI GE ++ G F P Sbjct: 117 PRYAILNRDPNNPKECNLIE----GEDHVEVNGEVFQKP 151 >4AEE-A nrPDB Length = 696 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 18/67 (26%), Positives = 29/67 (43%), Gaps = 2/67 (2%) Query: 227 IKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLD 286 ++ LG I L I Y Y + + GT E+ ++LV HS I ++LD Sbjct: 274 LEDLGVETIYLTPIFSSTSYHR--YDTIDYKSIDKYLGTMEDFEKLVQVLHSRKIKIVLD 331 Query: 287 VVHSHAS 293 + H + Sbjct: 332 ITMHHTN 338 >2ZIC-A nrPDB Length = 543 Score = 31.2 bits (69), Expect = 1.5, Method: Compositional matrix adjust. Identities = 14/48 (29%), Positives = 26/48 (54%) Query: 250 GYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSA 297 GY I ++ A + +G ++ L+ A GI +++D+V +H S A Sbjct: 62 GYDIANYEAIADIFGNMADMDNLLTQAKMRGIKIIMDLVVNHTSDEHA 109 >6AIJ-A nrPDB Length = 708 Score = 30.8 bits (68), Expect = 1.9, Method: Compositional matrix adjust. Identities = 15/44 (34%), Positives = 23/44 (52%) Query: 250 GYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHAS 293 GY F + +G + Q L+DTAH+ I V++D +H S Sbjct: 120 GYWARDFKQTNDAFGDFADFQNLIDTAHAHNIKVVIDFAPNHTS 163 >1M53-A nrPDB Length = 570 Score = 30.8 bits (68), Expect = 2.0, Method: Compositional matrix adjust. Identities = 14/44 (31%), Positives = 23/44 (52%) Query: 250 GYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHAS 293 GY I+++ YGT E+ LV + +++DVV +H S Sbjct: 76 GYDISNYRQIMKEYGTMEDFDSLVAEMKKRNMRLMIDVVINHTS 119 >5VTM-X nrPDB Length = 273 Score = 30.8 bits (68), Expect = 2.1, Method: Compositional matrix adjust. Identities = 23/64 (35%), Positives = 30/64 (46%), Gaps = 7/64 (10%) Query: 8 AARPEDYEAALNAALADVPELARLLEIDPYLKPYAVDFQRR-----YKQFSQILKNIGEN 62 +A PED A LN A VP LA + EIDP VD + R F++ L +G Sbjct: 166 SALPED--APLNVNTASVPVLAAMFEIDPGQAENIVDARGREGFQSKDDFTKHLTQLGSK 223 Query: 63 EGGI 66 G + Sbjct: 224 TGNV 227 >4CZY-B nrPDB Length = 429 Score = 30.4 bits (67), Expect = 2.4, Method: Compositional matrix adjust. Identities = 22/90 (24%), Positives = 40/90 (44%), Gaps = 18/90 (20%) Query: 543 FGHPEWLDFPRKGNNESYHYARRQ---FHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAA 599 FG+P W+ + + N H+A R+ + LT++ + +N +E W Sbjct: 54 FGYPSWM-YKAQNNKNGRHFALRRIEGYRLTNEKAI-----------LNVTKE---WKKI 98 Query: 600 PQAYVSEKHEGNKIIAFERAGLLFIFNFHP 629 A + HE F + L+F+++FHP Sbjct: 99 INANIVTVHEAFTTEFFGDSSLIFVYDFHP 128 >4HOX-A nrPDB Length = 559 Score = 30.4 bits (67), Expect = 2.6, Method: Compositional matrix adjust. Identities = 13/48 (27%), Positives = 22/48 (45%) Query: 250 GYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSA 297 GY I + YGT E+ L+ + +++D+V +H S A Sbjct: 63 GYDIRDYRKIMKEYGTMEDFDRLISEMKKRNMRLMIDIVINHTSDQHA 110 >3GBE-A nrPDB Length = 558 Score = 30.4 bits (67), Expect = 3.0, Method: Compositional matrix adjust. Identities = 13/44 (29%), Positives = 21/44 (47%) Query: 250 GYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHAS 293 GY I + YGT E+ L+ + +++DVV +H S Sbjct: 62 GYDIRDYRKIMKEYGTMEDFDRLISEMKKRNMRLMIDVVINHTS 105 >2D3L-A nrPDB Length = 485 Score = 29.6 bits (65), Expect = 4.9, Method: Compositional matrix adjust. Identities = 17/42 (40%), Positives = 23/42 (54%), Gaps = 2/42 (4%) Query: 261 SRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNM 302 ++YGT +LQ V + + GI V DVV +H K AD M Sbjct: 77 TKYGTRSQLQAAVTSLKNNGIQVYGDVVMNH--KGGADATEM 116 >1QI5-A nrPDB Length = 429 Score = 29.6 bits (65), Expect = 4.9, Method: Compositional matrix adjust. Identities = 13/42 (30%), Positives = 22/42 (52%) Query: 257 FAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSAD 298 F + RYG+ +L++ G+ VL DVV +H ++ D Sbjct: 83 FNKNGRYGSDAQLRQAASALGGAGVKVLYDVVPNHMNRGYPD 124 >3EHC-A nrPDB Length = 128 Score = 29.6 bits (65), Expect = 5.3, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 21/44 (47%), Gaps = 3/44 (6%) Query: 659 GHQRLDHSTDFFSEAFEHNGRPYSLLVYIPSRVALILQNVDLPN 702 HQ D F + EHNGRP+ L Y R L+ D+P+ Sbjct: 17 NHQAFDELGTFVDDNVEHNGRPFGLSGY---RDMLVKDFADIPD 57 >1BPL-A nrPDB Length = 189 Score = 29.3 bits (64), Expect = 5.5, Method: Compositional matrix adjust. Identities = 17/38 (44%), Positives = 22/38 (57%), Gaps = 2/38 (5%) Query: 261 SRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSAD 298 ++YGT ELQ + + HS I V DVV +H K AD Sbjct: 75 TKYGTKGELQSAIKSLHSRDINVYGDVVINH--KGGAD 110 >1GCY-A nrPDB Length = 527 Score = 29.3 bits (64), Expect = 5.7, Method: Compositional matrix adjust. Identities = 13/42 (30%), Positives = 22/42 (52%) Query: 257 FAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSAD 298 F + RYG+ +L++ G+ VL DVV +H ++ D Sbjct: 83 FNKNGRYGSDAQLRQAASALGGAGVKVLYDVVPNHMNRGYPD 124 >1BLI-A nrPDB Length = 483 Score = 29.3 bits (64), Expect = 5.9, Method: Compositional matrix adjust. Identities = 17/38 (44%), Positives = 22/38 (57%), Gaps = 2/38 (5%) Query: 261 SRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSAD 298 ++YGT ELQ + + HS I V DVV +H K AD Sbjct: 75 TKYGTKGELQSAIKSLHSRDINVYGDVVINH--KGGAD 110 >4CYJ-A nrPDB Length = 438 Score = 28.9 bits (63), Expect = 7.3, Method: Compositional matrix adjust. Identities = 25/98 (25%), Positives = 44/98 (44%), Gaps = 19/98 (19%) Query: 543 FGHPEWLDFPRKGNNESYHYARRQ---FHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAA 599 FG+P W+ + + + HYA R+ + LT++ K + N +D W Sbjct: 65 FGYPSWV-YKAQNSRNGRHYALRRLEGYRLTNE-----KAILNVMKD---------WKKI 109 Query: 600 PQAYVSEKHEGNKIIAFERAGLLFIFNFHP-SKSYTDY 636 A + HE F + L+F ++FHP SK+ ++ Sbjct: 110 KNASIVTIHEVFTTREFGDSSLIFAYDFHPLSKTLQEH 147 >6GXV-A nrPDB Length = 484 Score = 28.9 bits (63), Expect = 7.5, Method: Compositional matrix adjust. Identities = 26/102 (25%), Positives = 42/102 (41%), Gaps = 15/102 (14%) Query: 261 SRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHD 320 ++YGT +LQ + + H+ GI DVV +H + AD + P + Sbjct: 77 TKYGTKAQLQSAITSLHNNGIQAYGDVVLNH--RMGADATETISAVE-----VNPSNRNQ 129 Query: 321 LWDSRLFAYSSWEILRF-----LLSNIRWWLEEYRFDGFRFD 357 + S + S+W F S+ +W Y FDG +D Sbjct: 130 V-TSGAYNISAWTDFEFPGRGNTYSSFKW--HSYYFDGVDWD 168 >5ZCR-A nrPDB Length = 728 Score = 28.5 bits (62), Expect = 9.3, Method: Compositional matrix adjust. Identities = 19/74 (25%), Positives = 34/74 (45%) Query: 220 TCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSM 279 T L K LG + + L I++ ++ GY + + G E +LV A S Sbjct: 19 TIENLDYFKELGVSHLYLSPILKARPGSTHGYDVVDHSEINEELGGEEGYFKLVKEAKSR 78 Query: 280 GIIVLLDVVHSHAS 293 G+ ++ D+V +H + Sbjct: 79 GLEIIQDIVPNHMA 92 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5CLW-A nrPDB 945 0.0 3AMK-A nrPDB 824 0.0 3K1D-A nrPDB 580 e-166 5GQY-A nrPDB 559 e-159 5E70-A nrPDB 557 e-159 5H2T-A nrPDB 304 1e-82 4LXF-A nrPDB 280 2e-75 3ZO9-A nrPDB 265 4e-71 6JEQ-A nrPDB 259 4e-69 2WAN-A nrPDB 246 2e-65 2E8Y-A nrPDB 238 6e-63 1EHA-A nrPDB 222 4e-58 2BHU-A nrPDB 211 6e-55 3WDH-A nrPDB 197 2e-50 2VNC-A nrPDB 195 7e-50 3M07-A nrPDB 195 7e-50 5A2B-A nrPDB 183 2e-46 3FAW-A nrPDB 180 2e-45 5M99-B nrPDB 180 2e-45 2YA2-A nrPDB 180 2e-45 4E2O-A nrPDB 180 2e-45 4OKD-A nrPDB 174 2e-43 5ZCD-A nrPDB 169 4e-42 2WSK-A nrPDB 167 2e-41 1J0H-A nrPDB 166 4e-41 5OT1-A nrPDB 166 4e-41 1WZA-A nrPDB 164 8e-41 1SMA-A nrPDB 162 5e-40 5BRQ-A nrPDB 156 3e-38 2ZE0-A nrPDB 150 1e-36 5WCZ-A nrPDB 148 8e-36 1EA9-C nrPDB 147 2e-35 4GKL-A nrPDB 144 1e-34 3WY1-A nrPDB 141 1e-33 5H05-A nrPDB 136 3e-32 1V3M-A nrPDB 132 7e-31 3DHU-A nrPDB 131 1e-30 4CGT-A nrPDB 130 2e-30 1LWJ-A nrPDB 124 1e-28 2AAA-A nrPDB 123 3e-28 Sequences not found previously or not previously below threshold: 5X7U-A nrPDB 242 4e-64 5YKB-A nrPDB 218 7e-57 1UOK-A nrPDB 148 6e-36 5DO8-B nrPDB 145 7e-35 1JL8-A nrPDB 145 7e-35 2WC7-A nrPDB 142 5e-34 1BF2-A nrPDB 139 4e-33 1M53-A nrPDB 137 2e-32 1CYG-A nrPDB 135 6e-32 4HOX-A nrPDB 133 2e-31 4AIE-A nrPDB 131 8e-31 3GBE-A nrPDB 131 1e-30 4GI8-A nrPDB 131 1e-30 4J3X-A nrPDB 127 2e-29 2ZIC-A nrPDB 123 2e-28 2Z1K-A nrPDB 122 4e-28 1EO7-A nrPDB 121 9e-28 4JCM-A nrPDB 119 3e-27 3AXH-A nrPDB 119 3e-27 4AEE-A nrPDB 119 4e-27 6A0L-A nrPDB 119 4e-27 1QHO-A nrPDB 118 6e-27 1A47-A nrPDB 117 2e-26 2TAA-A nrPDB 115 5e-26 6AIJ-A nrPDB 114 1e-25 3VM7-A nrPDB 108 7e-24 4AEF-A nrPDB 106 3e-23 5BN7-A nrPDB 106 4e-23 3UEQ-A nrPDB 105 9e-23 3K8L-A nrPDB 103 2e-22 3EDF-A nrPDB 99 4e-21 3UER-A nrPDB 97 2e-20 2WPG-A nrPDB 91 1e-18 3CZE-A nrPDB 91 2e-18 5Z0U-A nrPDB 88 1e-17 1UA7-A nrPDB 83 4e-16 3HJE-A nrPDB 82 9e-16 3BCF-A nrPDB 80 4e-15 3DC0-A nrPDB 79 7e-15 1AVA-A nrPDB 79 8e-15 4AYS-A nrPDB 79 8e-15 5ZCR-A nrPDB 79 9e-15 1IV8-A nrPDB 78 2e-14 4UZU-A nrPDB 78 2e-14 3WN6-A nrPDB 76 5e-14 3BSH-A nrPDB 73 3e-13 1BLI-A nrPDB 73 4e-13 1E3X-A nrPDB 72 7e-13 6GXV-A nrPDB 72 8e-13 6IRT-A nrPDB 71 2e-12 1MXD-A nrPDB 71 2e-12 3BH4-A nrPDB 71 2e-12 2DH2-A nrPDB 70 4e-12 1UD8-A nrPDB 70 4e-12 3QGV-A nrPDB 68 2e-11 5CIM-A nrPDB 68 2e-11 4CN6-A nrPDB 64 2e-10 1GCY-A nrPDB 63 5e-10 4U33-A nrPDB 63 6e-10 2D3L-A nrPDB 62 8e-10 1QI5-A nrPDB 62 1e-09 2GJP-A nrPDB 60 3e-09 2DIE-A nrPDB 60 4e-09 1BPL-A nrPDB 58 2e-08 1GJU-A nrPDB 57 2e-08 1MFU-A nrPDB 57 3e-08 1JD7-A nrPDB 56 6e-08 1TMQ-A nrPDB 56 7e-08 3AIC-A nrPDB 50 3e-06 3VM5-A nrPDB 49 6e-06 3L2M-A nrPDB 49 9e-06 5JBE-A nrPDB 47 2e-05 5C8B-B nrPDB 44 2e-04 5X3I-A nrPDB 41 0.001 1BPL-B nrPDB 40 0.003 5I0E-B nrPDB 39 0.007 5WZN-A nrPDB 36 0.048 4BHW-A nrPDB 35 0.14 4ZMT-A nrPDB 35 0.15 4PZS-A nrPDB 34 0.27 5XZC-A nrPDB 33 0.42 5VTM-X nrPDB 33 0.57 5KJ2-A nrPDB 33 0.57 5I2U-A nrPDB 32 0.60 3DUG-A nrPDB 32 0.63 3HFQ-A nrPDB 32 0.89 3PLN-A nrPDB 32 1.0 6MRE-A nrPDB 32 1.1 2OV1-A nrPDB 32 1.2 2CKS-A nrPDB 31 1.3 3B0H-A nrPDB 31 1.3 1PQ4-A nrPDB 31 1.4 2Y2W-A nrPDB 31 1.7 5FUC-C nrPDB 31 1.8 4G80-S nrPDB 31 2.0 4G7Y-S nrPDB 31 2.0 5IHS-A nrPDB 31 2.2 1N26-A nrPDB 31 2.4 4ML9-A nrPDB 31 2.8 1Z0N-A nrPDB 30 3.0 2MAS-A nrPDB 30 3.0 5H8V-A nrPDB 30 3.3 1P9M-C nrPDB 30 3.8 4RER-B nrPDB 30 4.0 6B2E-B nrPDB 30 4.1 4BUB-A nrPDB 30 4.4 5JYL-A nrPDB 30 4.4 2PQ6-A nrPDB 29 4.9 2LU3-A nrPDB 29 4.9 2GK1-I nrPDB 29 4.9 2G3M-A nrPDB 29 5.1 4YEE-A nrPDB 29 5.4 2GJX-A nrPDB 29 5.9 5FTT-C nrPDB 29 6.5 2O8R-A nrPDB 29 6.6 4NQQ-A nrPDB 29 8.2 4ZCF-A nrPDB 29 8.8 2ARW-A nrPDB 29 9.0 >5CLW-A nrPDB Length = 668 Score = 945 bits (2441), Expect = 0.0, Method: Composition-based stats. Identities = 661/663 (99%), Positives = 663/663 (100%) Query: 38 LKPYAVDFQRRYKQFSQILKNIGENEGGIDKFSRGYESFGVHRCADGGLYCKEWAPGAEG 97 LKPYAVDFQRRYKQFSQILKNIGENEGGIDKFSRGYESFGVHRCADGGLYCKEWAPGAEG Sbjct: 6 LKPYAVDFQRRYKQFSQILKNIGENEGGIDKFSRGYESFGVHRCADGGLYCKEWAPGAEG 65 Query: 98 VFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGSKLKVVITSKSGEILYRI 157 VFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGSKLKVVITSKSGEILYRI Sbjct: 66 VFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGSKLKVVITSKSGEILYRI 125 Query: 158 SPWAKYVVREGDNVNYDWIHWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYK 217 SPWAKYVVREGDNVNYDWIHWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYK Sbjct: 126 SPWAKYVVREGDNVNYDWIHWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYK 185 Query: 218 HFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAH 277 HFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYG+PEELQELVDTAH Sbjct: 186 HFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGSPEELQELVDTAH 245 Query: 278 SMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRLFAYSSWEILRF 337 SMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRLFAYSSWE+LRF Sbjct: 246 SMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRLFAYSSWEVLRF 305 Query: 338 LLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLAN 397 LLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLAN Sbjct: 306 LLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLAN 365 Query: 398 HLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNM 457 HLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNM Sbjct: 366 HLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNM 425 Query: 458 GDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGI 517 GDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGI Sbjct: 426 GDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGI 485 Query: 518 QLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGNNESYHYARRQFHLTDDDLLRY 577 QLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGNNESYHYARRQFHLTDDDLLRY Sbjct: 486 QLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGNNESYHYARRQFHLTDDDLLRY 545 Query: 578 KFLNNFDRDMNRLEERYGWLAAPQAYVSEKHEGNKIIAFERAGLLFIFNFHPSKSYTDYR 637 KFLNNFDRDMNRLEERYGWLAAPQAYVSEKHEGNKIIAFERAGLLFIFNFHPSKSYTDYR Sbjct: 546 KFLNNFDRDMNRLEERYGWLAAPQAYVSEKHEGNKIIAFERAGLLFIFNFHPSKSYTDYR 605 Query: 638 VGTALPGKFKIVLDSDAAEYGGHQRLDHSTDFFSEAFEHNGRPYSLLVYIPSRVALILQN 697 VGTALPGKFKIVLDSDAAEYGGHQRLDHSTDFFSEAFEHNGRPYSLLVYIPSRVALILQN Sbjct: 606 VGTALPGKFKIVLDSDAAEYGGHQRLDHSTDFFSEAFEHNGRPYSLLVYIPSRVALILQN 665 Query: 698 VDL 700 VDL Sbjct: 666 VDL 668 >3AMK-A nrPDB Length = 702 Score = 824 bits (2128), Expect = 0.0, Method: Composition-based stats. Identities = 366/684 (53%), Positives = 472/684 (69%), Gaps = 17/684 (2%) Query: 31 LLEIDPYLKPYAVDFQRRYKQFSQILKNIGENEGGIDKFSRGYESFGVHRCADGGLYCKE 90 + ++DP L+ + F R K++ I ++EGG+++FS+GY FG++ DG +E Sbjct: 13 IYDLDPKLEEFKDHFNYRIKRYLDQKCLIEKHEGGLEEFSKGYLKFGIN-TVDGATIYRE 71 Query: 91 WAPGAEGVFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGSKLKVVITSKS 150 WAP A+ L G+FN WN + +K +G W + I K +PH SK+K Sbjct: 72 WAPAAQEAQLIGEFNNWNGAKHKMEKDKFGIWSIKISHVNGKPA-IPHNSKVKFRFRHGG 130 Query: 151 GEILYRISPWAKYVVREGDNVN--YDWIHWDPE--HSYEFKHSRPKKPRSLRIYESHVGI 206 G + RI W +Y + YD +HWDP Y FKH RP KP + RIYE+HVG+ Sbjct: 131 GAWVDRIPAWIRYATFDASKFGAPYDGVHWDPPACERYVFKHPRPPKPDAPRIYEAHVGM 190 Query: 207 SSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTP 266 S E +V++Y+ F NVLPRI+ YN +QLMAIMEH+YYASFGY +T+FFA SSR GTP Sbjct: 191 SGEEPEVSTYREFADNVLPRIRANNYNTVQLMAIMEHSYYASFGYHVTNFFAVSSRSGTP 250 Query: 267 EELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFD---GTDSCYFHSGPRGTHDLWD 323 E+L+ LVD AHS+G+ VL+DVVHSHAS N DGLN +D T YFH+G RG H LWD Sbjct: 251 EDLKYLVDKAHSLGLRVLMDVVHSHASNNVTDGLNGYDVGQNTHESYFHTGDRGYHKLWD 310 Query: 324 SRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGL 383 SRLF Y++WE+LRFLLSN+R+W++E+ FDGFRFDGVTSMLYHHHG+ +GF+G+Y EYF L Sbjct: 311 SRLFNYANWEVLRFLLSNLRYWMDEFMFDGFRFDGVTSMLYHHHGINKGFTGNYKEYFSL 370 Query: 384 QVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKW 443 D DA+ Y+MLANHL+H L P++ +AEDVSGMP LC P+ +GG GFD+RLAMAIPD+W Sbjct: 371 DTDVDAIVYMMLANHLMHKLLPEATIVAEDVSGMPVLCRPVDEGGVGFDFRLAMAIPDRW 430 Query: 444 IQLLKEFKDEDWNMGDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNM 503 I LK +D W+M +IV TLTNRRY EKCIAYAESHDQ++VGDK++AF LMD EMYT M Sbjct: 431 IDYLKNKEDRKWSMSEIVQTLTNRRYTEKCIAYAESHDQSIVGDKTIAFLLMDKEMYTGM 490 Query: 504 SVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGNNESYHYA 563 S L P +P I+RGI L KMI IT LGG+GYLNFMGNEFGHPEW+DFPR+GNN SY Sbjct: 491 SDLQPASPTINRGIALQKMIHFITMALGGDGYLNFMGNEFGHPEWIDFPREGNNWSYDKC 550 Query: 564 RRQFHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAAPQAYVSEKHEGNKIIAFERAGLLF 623 RRQ+ L D D LRYK++N FD+ MN LEE + +L++ + VS+ +E +K+I FER L+F Sbjct: 551 RRQWSLVDTDHLRYKYMNAFDQAMNALEEEFSFLSSSKQIVSDMNEKDKVIVFERGDLVF 610 Query: 624 IFNFHPSKSYTDYRVGTALPGKFKIVLDSDAAEYGGHQRLDHSTDFFSE--------AFE 675 +FNFHP+K+Y Y+VG LPGK+++ LDSDA +GGH R+ H D F+ Sbjct: 611 VFNFHPNKTYKGYKVGCDLPGKYRVALDSDALVFGGHGRVGHDVDHFTSPEGMPGVPETN 670 Query: 676 HNGRPYSLLVYIPSRVALILQNVD 699 N RP S V P R + VD Sbjct: 671 FNNRPNSFKVLSPPRTCVAYYRVD 694 >3K1D-A nrPDB Length = 722 Score = 580 bits (1494), Expect = e-166, Method: Composition-based stats. Identities = 183/669 (27%), Positives = 284/669 (42%), Gaps = 69/669 (10%) Query: 51 QFSQILKNIGENEGGIDKFSRGYESFGVH----RCADG---GLYCKEWAPGAEGVFLTGD 103 +F L + + + R +E G H ADG G+ WAP A+GV L G+ Sbjct: 96 RFLPTLGEVDLHLFAEGRHERLWEVLGAHPRSFTTADGVVSGVSFAVWAPNAKGVSLIGE 155 Query: 104 FNGWNPFSYPYKKLD-YGKWELYIPPKQNKSVLVPHGSKLKVVITSKSGEILYRISPWAK 162 FNGWN P + L G WEL+ P P K + G + R P+A Sbjct: 156 FNGWNGHEAPMRVLGPSGVWELFWPD-------FPCDGLYKFRVHGADGVVTDRADPFAF 208 Query: 163 ---YVVREGDNVNYDWIHWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYKHF 219 + V W + + R ++ YE H+G SY+ Sbjct: 209 GTEVPPQTASRVTSSDYTWGDDDWMAGRALRNPVNEAMSTYEVHLGSWRP---GLSYRQL 265 Query: 220 TCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSM 279 + I G+ ++L+ + EH + S+GYQ+TS++A +SR+GTP++ + LVD H Sbjct: 266 ARELTDYIVDQGFTHVELLPVAEHPFAGSWGYQVTSYYAPTSRFGTPDDFRALVDALHQA 325 Query: 280 GIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGP-RGTHDLWDSRLFAYSSWEILRFL 338 GI V++D V +H K A L FDGT Y HS P RG W + +F + E+ FL Sbjct: 326 GIGVIVDWVPAHFPK-DAWALGRFDGT-PLYEHSDPKRGEQLDWGTYVFDFGRPEVRNFL 383 Query: 339 LSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANH 398 ++N +WL+E+ DG R D V SMLY + +G G G + + +A+ +L N Sbjct: 384 VANALYWLQEFHIDGLRVDAVASMLYLDYSRPEG--GWTPNVHGGRENLEAVQFLQEMNA 441 Query: 399 LVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNMG 458 H + P +TIAE+ + + P + GG GF + M W+ ++ Sbjct: 442 TAHKVAPGIVTIAEESTPWSGVTRPTNIGGLGFSMKWNMG----WMHDTLDYVSR----- 492 Query: 459 DIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGIQ 518 D VY + + + YA S + L L E+ L P + ++ Sbjct: 493 DPVYRSYHHHEMTFSMLYAFSENYVLP--------LSHDEVVHGKGTLWGRMPG-NNHVK 543 Query: 519 LHKMIRLITHGLGGEG-YLNFMGNEFGHP-EW-----LDFPRKGNNESYHYARRQFHLTD 571 + L+ + G L FMG EFG EW LD+ + N + +R + Sbjct: 544 AAGLRSLLAYQWAHPGKQLLFMGQEFGQRAEWSEQRGLDWFQLDENGFSNGIQRLVRDIN 603 Query: 572 DDLLRYKFLNNFDRDMNRLEERYGWLAAPQAYVSEKHEGNKIIAFERAG-----LLFIFN 626 D + L + D E Y W+ A N +++F R G L +FN Sbjct: 604 DIYRCHPALWSLD----TTPEGYSWIDA-------NDSANNVLSFMRYGSDGSVLACVFN 652 Query: 627 FHPSKSYTDYRVGTALPGKFKIVLDSDAAEYGGHQRLDHSTDFFSEAFEHNGRPYSLLVY 686 F + DYR+G G+++ VL++DA Y G + ++ H GRP S ++ Sbjct: 653 F-AGAEHRDYRLGLPRAGRWREVLNTDATIYHGSGIGNLGGVDATDDPWH-GRPASAVLV 710 Query: 687 IPSRVALIL 695 +P AL L Sbjct: 711 LPPTSALWL 719 >5GQY-A nrPDB Length = 793 Score = 559 bits (1441), Expect = e-159, Method: Composition-based stats. Identities = 173/678 (25%), Positives = 296/678 (43%), Gaps = 97/678 (14%) Query: 69 FSRGYESFGVHRCADGGL---YCKEWAPGAEGVFLTGDFNGWNPFSYPYKKLDYGKWELY 125 R YE G H G+ Y WAP A V + GDFN W+ + +K +Y WEL+ Sbjct: 142 HHRIYEKLGAHVGEINGVKGVYFAVWAPNARNVSVIGDFNNWDGREHQMRKRNYTIWELF 201 Query: 126 IPPKQNKSVLVPHGSKLKVVITSKSGEILYRISPWAKYVVREGDNVNY-----DWIHWDP 180 +P + G+ K I + G I + P+ Y + + + W Sbjct: 202 VPE-------IGSGTVYKYEIKNSEGHIYEKSDPYGFYREVRPNTASIVVDIDNIYQWHD 254 Query: 181 EHSYEFKHSRPKKPRSLRIYESHVGIS------------------------SHEGKVASY 216 E E + + + + +YE H+G + + SY Sbjct: 255 EEWLEKRRNSDPLKQPVSVYEVHLGSWLHGSSAEKMPLLNGEADPVIVSEWNPGARFLSY 314 Query: 217 KHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTA 276 ++P +K +GY I+L+ I EH + S+GYQ+T F++ +SR+G PE+ VD Sbjct: 315 YELAEKLIPYVKDMGYTHIELLPIAEHPFDGSWGYQVTGFYSPTSRFGRPEDFMYFVDKC 374 Query: 277 HSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPR-GTHDLWDSRLFAYSSWEIL 335 H GI V+LD V H K+S GL FDGT Y H+ PR G H W + +F Y E+ Sbjct: 375 HENGIGVILDWVPGHFPKDSH-GLAYFDGTH-LYEHADPRIGEHKEWGTLVFNYGRHEVR 432 Query: 336 RFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLML 395 FL++N+ +W ++Y DG R D V SMLY ++ +G + +G +A++++ Sbjct: 433 NFLVANVLFWFDKYHVDGIRVDAVASMLYRNYLRKEGEW--IANEYGGDEHIEAVSFIRE 490 Query: 396 ANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKD--- 452 N L+ P ++IAE+ + + P+ GG GF+ + M W+ + ++ + Sbjct: 491 VNTLLFEYFPGILSIAEESTEWEKVSRPVYDGGLGFNLKWDMG----WMHDMLDYFNIDP 546 Query: 453 --EDWNMGDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFT 510 ++ ++ +++ Y + A SHD+ + G ++ + E +V FT Sbjct: 547 YFRQYHQNNVTFSML--YYYNENFMLALSHDEIVHGKSNMLGKMPGDEWQKYANVRALFT 604 Query: 511 PVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGNNESYHYARRQFHLT 570 + TH G+ + FM EFG W ++ G+ E +H + + H Sbjct: 605 -------------YMYTH--PGKKTM-FMSMEFGQ--WSEWNVWGDLE-WHLLQYEPH-- 643 Query: 571 DDDLLRYKFLNNFDRDMNRLEERYGWLAAPQ------AYVSEKHEGNKIIAFERA----- 619 + L F D+N L ++ L ++ + +++F R Sbjct: 644 -------QQLKQFFTDLNALYQQEPALYTHDFEYHGFEWIDCNDNTHSVVSFLRRSDDPN 696 Query: 620 -GLLFIFNFHPSKSYTDYRVGTALPGKFKIVLDSDAAEYGGHQRLDHSTDFFSEAFEHNG 678 L+ + NF P + ++ YR+G G + + +SDA +YGG + + E HN Sbjct: 697 DSLVVVCNFTP-QPHSHYRIGVPEAGYYVELFNSDAKQYGGSNMGNLGGKWADEWSFHN- 754 Query: 679 RPYSLLVYIPSRVALILQ 696 +PYSL + +P LIL+ Sbjct: 755 KPYSLDLCLPPLAVLILK 772 >5E70-A nrPDB Length = 612 Score = 557 bits (1434), Expect = e-159, Method: Composition-based stats. Identities = 170/658 (25%), Positives = 279/658 (42%), Gaps = 79/658 (12%) Query: 69 FSRGYESFGVH-RCADG--GLYCKEWAPGAEGVFLTGDFNGWNPFSYPYK-KLDYGKWEL 124 R YE+ G H DG G WAP A V + G FN W+ +P + + + G WEL Sbjct: 2 HLRPYETLGAHADTMDGVTGTRFSVWAPNARRVSVVGQFNYWDGRRHPMRLRKESGIWEL 61 Query: 125 YIPPKQNKSVLVPHGSKLKVVITSKSGEILYRISPWAKYVVREGDNVNYDWIHWDPEHSY 184 +IP N G K + +G + + P+A + + I PE Sbjct: 62 FIPGAHN-------GQLYKYEMIDANGNLRLKSDPYAFEAQMRPETASL--ICGLPEKVV 112 Query: 185 EFKHSRPKKPRSL--RIYESHVGI---SSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMA 239 + + + IYE H+G + SY+ ++P K +G+ ++L+ Sbjct: 113 QTEERKKANQFDAPISIYEVHLGSWRRHTDNNFWLSYRELADQLVPYAKWMGFTHLELLP 172 Query: 240 IMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADG 299 I EH + S+GYQ T +A + R+GT ++ + +D AH+ G+ V+LD V H + Sbjct: 173 INEHPFDGSWGYQPTGLYAPTRRFGTRDDFRYFIDAAHAAGLNVILDWVPGHFPTDDF-A 231 Query: 300 LNMFDGTDSCYFHSGPR-GTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDG 358 L FDGT + Y HS PR G H W++ ++ Y E+ FL+ N +W+E + D R D Sbjct: 232 LAEFDGT-NLYEHSDPREGYHQDWNTLIYNYGRREVSNFLVGNALYWIERFGIDALRVDA 290 Query: 359 VTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMP 418 V SM+Y + +G FG + + +A+ +L N ++ ++T+AE+ + P Sbjct: 291 VASMIYRDYSRKEGEW--IPNEFGGRENLEAIEFLRNTNRILGEQVSGAVTMAEESTDFP 348 Query: 419 ALCSPISQGGGGFDYRLAMAIPDKWIQLLK------EFKDEDWNMGDIVYTLTNRRYLEK 472 + P GG GF Y+ + + +K ++ + G I+Y T + Sbjct: 349 GVSRPQDMGGLGFWYKWNLGWMHDTLDYMKLDPVYRQYHHDKLTFG-ILYNYT------E 401 Query: 473 CIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGG 532 SHD+ + G KS+ M + + + L + + G Sbjct: 402 NFVLPLSHDEVVHGKKSILD-RMPGDAWQKFANLRAYYGWM--------------WAFPG 446 Query: 533 EGYLNFMGNEFGH-PEW-----LDFPRKGNNESYHYA-RRQFHLTDDDLLRYKFLNNFDR 585 + L FMGNEF EW LD+ +++H+ +R + +K ++ D Sbjct: 447 KKLL-FMGNEFAQGREWNHDASLDWHLLEGGDNWHHGVQRLVRDLNLTYRHHKAMHELDF 505 Query: 586 DMNRLEERYGWLAAPQA------YVSEKHEGNKIIAFERAGLLFIFNFHPSKSYTDYRVG 639 D E WL +V EGN+II NF P + DYR G Sbjct: 506 DPYGFE----WLVVDDKERSVLIFVRRDKEGNEIIVAS--------NFTPVPRH-DYRFG 552 Query: 640 TALPGKFKIVLDSDAAEYGGHQRLDHSTDFFSEAFEHNGRPYSLLVYIPSRVALILQN 697 PGK++ +L++D+ Y G + T E H GR +SL + +P + L Sbjct: 553 INQPGKWREILNTDSMHYHGSNAGNGGTVHSDEIASH-GRQHSLSLTLPPLATIWLVR 609 >5H2T-A nrPDB Length = 601 Score = 304 bits (778), Expect = 1e-82, Method: Composition-based stats. Identities = 87/421 (20%), Positives = 143/421 (33%), Gaps = 68/421 (16%) Query: 178 WDPEHSYEFKHSRPKKP---RSLRIYESHV-GISSHEGKVASYKHFTCNVLPRIKGLGYN 233 F H +P+ P + YE V G S N L ++ LG + Sbjct: 4 TGDPIPDTFTHEKPRDPYWYKHAVFYEVLVRGFSDSNDDGTGDLRGLINRLDYLQWLGID 63 Query: 234 CIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHAS 293 CI L+ I + GY I+ + +G + ELVD AH GI V+ D+V +H S Sbjct: 64 CIWLLPIYQSPLRDG-GYDISDYTKILPEFGDLGDFVELVDEAHRRGIRVIADLVMNHTS 122 Query: 294 KNSADG-------------LNMFDGTDSCY--------------FHSGPRGTHDLW---- 322 M+ TD Y + P W Sbjct: 123 DQHPWFQASRTDPDGPYGDFYMWSDTDDKYPDARIIFVDTEVSNWTYDPVRGQYYWHRFF 182 Query: 323 -DSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYF 381 Y + + +L +R+WL + DGFR D V + E Sbjct: 183 SHQPDLNYDNPAVQEAMLEVLRFWL-DLGIDGFRLDAVPYLYAR-------------EGT 228 Query: 382 GLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPI--SQGGGGFDYRLAMAI 439 + + YL V L PD + +AE + PA GG + +A Sbjct: 229 NCENLPETHAYLKRVRAEVDRLYPDRVLLAE-ANQWPADVVEYFGDPATGGDECHMAFHF 287 Query: 440 PDKWIQLLKEFKDEDWNMGDIVYTLTNRRYLEKCI--AYAESHDQ---ALVGDKS----L 490 P + +++ + + +I+ + E C + +HD+ +V D+ Sbjct: 288 PVMPRIFMAVRREQRYPISEIM--AQTPKIPENCQWGIFLRNHDELTLEMVTDEERDYMY 345 Query: 491 AFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPE--W 548 A + D M N+ + P++D ++ + L G L + G+E G + W Sbjct: 346 AEYAKDPRMKANIGIRRRLAPLLDNDRNQLELFTALLLSLPGSPVL-YYGDEIGMGDNIW 404 Query: 549 L 549 L Sbjct: 405 L 405 >4LXF-A nrPDB Length = 620 Score = 280 bits (715), Expect = 2e-75, Method: Composition-based stats. Identities = 75/437 (17%), Positives = 139/437 (31%), Gaps = 68/437 (15%) Query: 162 KYVVREGDNVNYDWIHWDPEHSYEFKHSRPKKP---RSLRIYESHVG-ISSHEGKVASYK 217 ++ +G +V + + + P P + YE V + Sbjct: 28 EHPPVQGSHVEGGVVEHPDAKDFGSAAALPADPTWFKHAVFYEVLVRAFFDASADGSGDL 87 Query: 218 HFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAH 277 + L ++ LG +CI L + GY I F+ +GT ++ LVD AH Sbjct: 88 RGLIDRLDYLQWLGIDCIWLPPFYDSPLRDG-GYDIRDFYKVLPEFGTVDDFVALVDAAH 146 Query: 278 SMGIIVLLDVVHSHASKNSADGLNMFDGTDSCY--------------------------- 310 GI ++ D+V +H S++ D Y Sbjct: 147 RRGIRIITDLVMNHTSESHPWFQESRRDPDGPYGDYYVWSDTSERYTDARIIFVDTEESN 206 Query: 311 FHSGPRGTHDLW-----DSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYH 365 + P W Y + + ++ IR+WL DGFR D V + Sbjct: 207 WSFDPVRRQFYWHRFFSHQPDLNYDNPAVQEAMIDVIRFWLG-LGIDGFRLDAVPYLFER 265 Query: 366 HHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPI- 424 E + + +L +V P + +AE + P Sbjct: 266 -------------EGTNCENLPETHAFLKRVRKVVDDEFPGRVLLAE-ANQWPGDVVEYF 311 Query: 425 -SQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNMGDIVYTLTNRRYLEKCI--AYAESHD 481 GG + +A P + ++ + + +I+ + + +HD Sbjct: 312 GDPNTGGDECHMAFHFPLMPRIFMAVRRESRFPISEII--AQTPPIPDMAQWGIFLRNHD 369 Query: 482 Q---ALVGDKS----LAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEG 534 + +V D+ A + D M N+ + P++D ++ + L G Sbjct: 370 ELTLEMVTDEERDYMYAEYAKDPRMKANVGIRRRLAPLLDNDRNQIELFTALLLSLPGSP 429 Query: 535 YLNFMGNEFGHPE--WL 549 L + G+E G + WL Sbjct: 430 VL-YYGDEIGMGDVIWL 445 >3ZO9-A nrPDB Length = 593 Score = 265 bits (678), Expect = 4e-71, Method: Composition-based stats. Identities = 70/401 (17%), Positives = 125/401 (31%), Gaps = 65/401 (16%) Query: 195 RSLRIYESHVGIS-SHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQI 253 + YE V L IK LG +C+ L + GY I Sbjct: 37 KHAVFYEVLVRAFYDSNADGIGDLRGLTEKLDYIKWLGVDCLWLPPFYDSPLRDG-GYDI 95 Query: 254 TSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCY--- 310 F+ +GT ++ L+D AH GI ++ D+V +H S D Y Sbjct: 96 RDFYKVLPEFGTVDDFVTLLDAAHRRGIRIITDLVMNHTSDQHEWFQESRHNPDGPYGDF 155 Query: 311 ------------------------FHSGPRGTHDLW-----DSRLFAYSSWEILRFLLSN 341 + P W Y + + +L Sbjct: 156 YVWSDTSDRYPDARIIFVDTEESNWTFDPVRRQFYWHRFFSHQPDLNYDNPAVQEAMLDV 215 Query: 342 IRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVH 401 +R+WL + DGFR D V + E + + +L + Sbjct: 216 LRFWL-DLGIDGFRLDAVPYLFER-------------EGTNCENLPETHAFLKRCRKAID 261 Query: 402 TLCPDSITIAEDVSGMPALCSPI--SQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNMGD 459 P + +AE + PA GG + +A P + ++ + + + Sbjct: 262 DEYPGRVLLAE-ANQWPADVVAYFGDPDTGGDECHMAFHFPLMPRIFMAVRRESRFPISE 320 Query: 460 IVYTLTNRRYLEKCI--AYAESHDQ---ALVGDKS----LAFWLMDAEMYTNMSVLTPFT 510 I+ + + +HD+ +V D+ A + D M N+ + Sbjct: 321 IL--AQTPPIPDTAQWGIFLRNHDELTLEMVTDEERDYMYAEYAKDPRMKANVGIRRRLA 378 Query: 511 PVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPE--WL 549 P+++ ++ + L G L + G+E G + WL Sbjct: 379 PLLENDRNQIELFTALLLSLPGSPVL-YYGDEIGMGDIIWL 418 >6JEQ-A nrPDB Length = 675 Score = 259 bits (661), Expect = 4e-69, Method: Composition-based stats. Identities = 78/346 (22%), Positives = 122/346 (35%), Gaps = 58/346 (16%) Query: 64 GGIDKFSRGYESFGVHRCAD-GGLYCKE------WAPGAEGVF--LTGDFNGWNPFSYPY 114 GGI F ++ V+ D G +Y E WAP A F L +G P Sbjct: 21 GGISVFDAKFDELYVYDGDDLGAVYAPEETRFRLWAPTASEAFVVLYETEDGMPVKELPM 80 Query: 115 KKLDYGKWELYIPPKQNKSVLVPHGSKLKVVITSKSGEILYRISPWAKYVVREGDNVN-Y 173 K+ G W L + +V + + E + P+AK V G Sbjct: 81 KRDVQGTWTLTVAEDCGGLFYT-----YRVKVGEQWNE---AVDPYAKAVGVNGTKTAIL 132 Query: 174 DWIHWDPEHSYEFKHSRPKKPRSLRIYESHV---GISSHEGKVASYKHFTCN-------- 222 D +PE + P IYE HV I G K Sbjct: 133 DLRSTNPEGWENDQKPPLASPTDAVIYELHVRDLSIHPQSGIREKGKFLGLTEEGTRGPN 192 Query: 223 ----VLPRIKGLGYNCIQLMAIMEHAY-----------YASFGYQITSFFAASSRYGTPE 267 L I GLG +QL+ I +++ + ++GY ++ Y T Sbjct: 193 GIPTGLDHITGLGVTHVQLLPIYDYSQESVDESRLDEPHYNWGYDPQNYNVPEGSYSTDP 252 Query: 268 --------ELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYF--HSGPRG 317 EL+ L+ H+ G+ V++DVV++H L F Y+ + R Sbjct: 253 HNPAARILELKRLIQKLHARGLRVIMDVVYNHVYDGY---LIHFTKLVPGYYLRYKADRT 309 Query: 318 THD-LWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSM 362 D + A + ++++ +I W+ EY DGFRFD + + Sbjct: 310 FSDGTFCGNECASERPIMRKYIIESILHWVREYHIDGFRFDLMGMI 355 >2WAN-A nrPDB Length = 921 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 100/535 (18%), Positives = 166/535 (31%), Gaps = 88/535 (16%) Query: 66 IDKFSRGYESFGVHRCADGGLYCKEWAPGAEGVFL--TGDFNGWNPFSYPYKKLDYGKWE 123 + ++ G D + WAP A V L G +K D G W+ Sbjct: 308 LPRYDYSGNDLGNVYSKD-ATSFRVWAPTASNVQLLLYNSEKGSITKQLEMQKSDNGTWK 366 Query: 124 LYIPPKQNKSVLVPHGSKLKVVITSKSGEILYRISPWAKYVVREGDN-VNYDWIHWDPEH 182 L + +V + +G + P+A+ + + D DP Sbjct: 367 LQVSGNLENWYY-----LYQVTV---NGTTQTAVDPYARAISVNATRGMIVDLKATDPAG 418 Query: 183 SYEFKHSRPKKPRSLRIYESHV---GISSHEGKVASYKHFT------------CNVLPRI 227 P P IYE+HV I ++ G K+ + + Sbjct: 419 WQGDHEQTPANPVDEVIYEAHVRDFSIDANSGMKNKGKYLAFTEHGTKGPDHVKTGIDSL 478 Query: 228 KGLGYNCIQLMAIMEH-------AYYASFGYQITSFFAASSRYGT-PE------ELQELV 273 K LG +QL + E ++GY ++ Y T PE EL++L+ Sbjct: 479 KELGITTVQLQPVEEFNSIDETQPDTYNWGYDPRNYNVPEGAYATTPEGTARITELKQLI 538 Query: 274 DTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHDLWDS--RLFAYSS 331 + H I V +DVV++H + Y+ + G + FA Sbjct: 539 QSLHQQRIGVNMDVVYNHTFDVMVSDFDKIVP--QYYYRTDSNGNYTNGSGCGNEFATEH 596 Query: 332 WEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALT 391 +F+L ++ +W+ EY DGFRFD + Sbjct: 597 PMAQKFVLDSVNYWVNEYHVDGFRFDLMA--------------------------LLGKD 630 Query: 392 YLMLANHLVHTLCPDSITIAEDVS-GMPALCSPI-----SQGGGG---FDYRLAMAIPDK 442 + ++ +H + P + E + G L S Q G G F+ + + Sbjct: 631 TMAKISNELHAINPGIVLYGEPWTGGTSGLSSDQLVTKGQQKGLGIGVFNDNIRNGLDGN 690 Query: 443 WIQLLKE-FKDEDWNMGDIVYTLTNRRY------LEKCIAYAESHDQALVGDKSLAFWLM 495 + F D N D++ + I Y SHD + DK LA Sbjct: 691 VFDKTAQGFATGDPNQVDVIKNGVIGSIQDFTSAPSETINYVTSHDNMTLWDKILASNPS 750 Query: 496 DAEM-YTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEWL 549 D E M L +G+ + + GG G+ +W Sbjct: 751 DTEADRIKMDELAHAVVFTSQGVPFMQGGEEMLRTKGGNDNSYNAGDSVNQFDWS 805 >5X7U-A nrPDB Length = 549 Score = 242 bits (617), Expect = 4e-64, Method: Composition-based stats. Identities = 71/399 (17%), Positives = 131/399 (32%), Gaps = 63/399 (15%) Query: 188 HSRPKKPRSLRIYESHVG-ISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYY 246 + P + IYE V + L I+ LG I L+ Sbjct: 2 NDDPTWYKDAIIYEVGVRCFFDSNNDGSGDIPGLTAKLDYIESLGVTAIWLLPFYASPLK 61 Query: 247 ASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGT 306 GY I+ + + +GT E+ + +D AH GI V+ ++V +H S Sbjct: 62 DG-GYDISDYRSLHPDFGTIEDFKVFLDEAHRRGIRVITELVLNHTSDQHQWFREARSNP 120 Query: 307 DSCY-----FHSGPRGTHD-------------LWD--------------SRLFAYSSWEI 334 +S Y + D WD Y + ++ Sbjct: 121 NSPYRDYYVWSDTDDKYKDARIIFIDTERSNWTWDQEAGKYYWHRFFSHQPDLNYDNPKV 180 Query: 335 LRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLM 394 + +L + +WL + DG R D V LY G + + +L Sbjct: 181 QQEILDIVGYWL-DMGVDGLRLDAVPY-LYEREGT------------NCENLPETHEFLK 226 Query: 395 LANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDED 454 V P+ + +AE + P G G + +A P + +++ Sbjct: 227 KLRKFVDDNWPNRMLLAE-ANQWPEDVVAYF--GNGDECHMAYHFPIMPRMYMALRREDR 283 Query: 455 WNMGDIVYTLTNRRYLEKCI--AYAESHDQ---ALVGDKS----LAFWLMDAEMYTNMSV 505 + +I+ E C + +HD+ +V D+ + D M N+ + Sbjct: 284 HPITEILRR--TPPIPETCQWALFLRNHDELTLEMVTDEERDYMYHEYAKDPRMRLNLGI 341 Query: 506 LTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFG 544 P++D + +++ L+ L G + + G+E G Sbjct: 342 RRRLAPLLDNSERRIQLMHLLLFTLPGTPII-YYGDEIG 379 >2E8Y-A nrPDB Length = 718 Score = 238 bits (607), Expect = 6e-63, Method: Composition-based stats. Identities = 70/322 (21%), Positives = 118/322 (36%), Gaps = 55/322 (17%) Query: 75 SFGVHRCADGGLYCKEWAPGAEGVFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSV 134 G AD + K WAP A + + ++ +L+ G + + + Sbjct: 105 ELGAVYTADHTV-FKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDL---- 159 Query: 135 LVPHGSKLKVVITSKSGEILYRISPWAKYVVREGDN---VNYDWIHWDPEHSYEFKHSRP 191 HG + I + S E + + +AK V G+ + D + W Sbjct: 160 ---HGYEYLFCICNNS-EWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPL------KPF 209 Query: 192 KKPRSLRIYESHV---GISSHEGKVASYKHFTCN------------VLPRIKGLGYNCIQ 236 P IYE+H+ I + G + K+ L +K LG ++ Sbjct: 210 SHPVDAVIYETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVE 269 Query: 237 LMAIMEHAYYA--------SFGYQITSFFAASSRYGT--------PEELQELVDTAHSMG 280 L+ + + A ++GY FFA Y + EL+++++T H G Sbjct: 270 LLPVNDFAGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHG 329 Query: 281 IIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRG---THDLWDSRLFAYSSWEILRF 337 + V+LDVV +H K F+ T YF ++ A +F Sbjct: 330 LRVILDVVFNHVYKRENSP---FEKTVPGYFFRHDECGKPSNGTGVGNDIASERRMARKF 386 Query: 338 LLSNIRWWLEEYRFDGFRFDGV 359 + + +WLEEY DGFRFD + Sbjct: 387 IADCVVYWLEEYNVDGFRFDLL 408 >1EHA-A nrPDB Length = 558 Score = 222 bits (565), Expect = 4e-58, Method: Composition-based stats. Identities = 107/494 (21%), Positives = 172/494 (34%), Gaps = 101/494 (20%) Query: 78 VHRCADGGLYCKEWAPGAEGVFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVP 137 ++ + WAP + V L G Y ++ + G + + + V Sbjct: 3 AYKIDGNEVIFTLWAPYQKSVKLKVLEKGL----YEMERDEKGYFTITLNN-------VK 51 Query: 138 HGSKLKVVITSKSGEILYRISPWAKYVVREGDNVNYDWIHWDPEHSYEFKHSRPKKPRSL 197 + K V+ S EI S + V + + S EF + K L Sbjct: 52 VRDRYKYVLDDAS-EIPDPASRYQPEGVHGPSQII--------QESKEFNNETFLKKEDL 102 Query: 198 RIYESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFF 257 IYE HVG + EG L +K LG I++M I + +GY + Sbjct: 103 IIYEIHVGTFTPEGTFEG----VIRKLDYLKDLGITAIEIMPIAQFPGKRDWGYDGVYLY 158 Query: 258 AASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRG 317 A + YG PE ++LVD AH G+ V+LDVV++H + + G + P G Sbjct: 159 AVQNSYGGPEGFRKLVDEAHKKGLGVILDVVYNHVGPEGNYMVKL--GPYFSQKYKTPWG 216 Query: 318 THDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDY 377 +D S E+ +F+L N+ +W++EY DGFR D V +++ Sbjct: 217 LTFNFDDA----ESDEVRKFILENVEYWIKEYNVDGFRLDAVHAII-------------- 258 Query: 378 SEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAM 437 D L +VH + I IAE P + +P + G D + Sbjct: 259 --------DTSPKHILEEIADVVHKY--NRIVIAESDLNDPRVVNPKEKVGYNIDAQWVD 308 Query: 438 AIPDKWIQLL----KEFKDEDWNMGDIVYTLTNRRYLE---------------------K 472 L + + + N+ DIV + + + Sbjct: 309 DFHHSIHAYLTGERQGYYTDFGNLDDIVKSYKDVFVYDGKYSNFRRKTHGEPVGELDGCN 368 Query: 473 CIAYAESHDQA-LVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLG 531 + Y ++HDQ G L+D E Y + L +P I Sbjct: 369 FVVYIQNHDQVGNRGKGERIIKLVDRESYKIAAALYLLSPYIP----------------- 411 Query: 532 GEGYLNFMGNEFGH 545 + FMG E+G Sbjct: 412 ----MIFMGEEYGE 421 >5YKB-A nrPDB Length = 571 Score = 218 bits (555), Expect = 7e-57, Method: Composition-based stats. Identities = 67/404 (16%), Positives = 128/404 (31%), Gaps = 63/404 (15%) Query: 195 RSLRIYESHVGIS-SHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQI 253 +S YE V G + L +K LG +C+ L+ GY + Sbjct: 12 KSAVFYELSVRTFQDGNGDGKGDFPGLTSRLDYLKNLGVDCLWLLPWFPSPLRDD-GYDV 70 Query: 254 TSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDG-------- 305 + GT ++ + + AH+ G+ V+ D+V +H S + G Sbjct: 71 ADYRGIHPDLGTLDDFKVFLREAHARGLWVIGDLVTNHTSSDHPWFQAARRGPTLPDGSP 130 Query: 306 --TDSCYFHSGPRGTH-----------------------DLW-----DSRLFAYSSWEIL 335 Y S + W Y + +++ Sbjct: 131 NEYHDYYVWSDEGKEYADTRIIFTDTEVSNWTLDEQAGKYYWHRFFASQPDLNYDNPKVV 190 Query: 336 RFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLML 395 L R+WL + DGFR D V ++ E + + L Sbjct: 191 EELHGAARFWL-DLGLDGFRVDAVPYLIER-------------EGTSCENLPETHEILKG 236 Query: 396 ANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDW 455 +V P + +AE P ++ + P + +++ Sbjct: 237 FRAMVDREYPGRLLLAEAF-QWPEEVVEYFGTEAEPEFHMCFNFPVMPRLYMSLKREDTS 295 Query: 456 NMGDIVYTLTNRRYLEKCIAYAESHDQ---ALVGDKS----LAFWLMDAEMYTNMSVLTP 508 ++ +I+ L + + +HD+ +V D A + DA M N+ + Sbjct: 296 SIREIMGRLPKIPSFGQWCIFLRNHDELTLEMVTDDERAFMYAAYAPDARMKINVGIRRR 355 Query: 509 FTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFP 552 P++D + +++ + L G L + G+E G + L P Sbjct: 356 LAPLLDNDRRRIELLNTVLLALPGSPVL-YYGDEIGMGDDLGLP 398 >2BHU-A nrPDB Length = 602 Score = 211 bits (538), Expect = 6e-55, Method: Composition-based stats. Identities = 81/330 (24%), Positives = 124/330 (37%), Gaps = 49/330 (14%) Query: 85 GLYCKEWAPGAEGVFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGSKLKV 144 G + W A V + N + L G +EL +P V G++ Sbjct: 35 GTRFRLWTSTARTVAVR-----VNGTEHVMTSLGGGIYELELP--------VGPGARYLF 81 Query: 145 VITSKSGEILYRISPWAKYVVR----EGDNVNYDWIHWDPEHSYEFKHSRPKKPRSLRIY 200 V+ + P+A+++ E + V++ W + K Y Sbjct: 82 VLDG-----VPTPDPYARFLPDGVHGEAEVVDFGTFDWTDADWHG------IKLADCVFY 130 Query: 201 ESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAAS 260 E HVG + EG + LP +K LG IQ+M + +GY +F+A Sbjct: 131 EVHVGTFTPEGTYRA----AAEKLPYLKELGVTAIQVMPLAAFDGQRGWGYDGAAFYAPY 186 Query: 261 SRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHD 320 + YG PE+L LVD AH +G+ V LDVV++H + N YF Sbjct: 187 APYGRPEDLMALVDAAHRLGLGVFLDVVYNHFGPSG----NYLSSYAPSYF---TDRFSS 239 Query: 321 LWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEY 380 W Y+ + R++ N R WL +Y FDG R D M Sbjct: 240 AWGMG-LDYAEPHMRRYVTGNARMWLRDYHFDGLRLDATPYMT-------DDSETHILTE 291 Query: 381 FGLQVDEDALTYLMLANHLVHTLCPDSITI 410 ++ E T+L+LA H PD +T+ Sbjct: 292 LAQEIHELGGTHLLLAED--HRNLPDLVTV 319 >3WDH-A nrPDB Length = 710 Score = 197 bits (500), Expect = 2e-50, Method: Composition-based stats. Identities = 72/362 (19%), Positives = 117/362 (32%), Gaps = 56/362 (15%) Query: 38 LKPYAVDFQRRYKQFSQILKNIGENEGGIDKFSRGYESFGVHRCAD-GGLY------CKE 90 L P+ V+ +RY +++ + G + + ++ ++ + D G Y K Sbjct: 66 LVPFIVELGKRYVVYTEEGWQVPLQVGAVMR-TKAFDDLYAYDGNDLGATYDPEKTTFKV 124 Query: 91 WAPGAEGVFLTGDFNG-WNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGSKLKVVITSK 149 WAP A V L +Y + G W + + + Sbjct: 125 WAPTATDVLLKLIHPTTKEETTYVMTREKKGLWTYTVYDDVERFLYTYMTYV-------- 176 Query: 150 SGEILYRISPWAKYVVREGD-NVNYDWIHWDPEHSYEFKHSRPKKPRSLRIYESHVG--- 205 + + P+AK V G V D + S IYE H+ Sbjct: 177 NFIWREAVDPYAKSVSVNGTYGVVVDLAKTNIPKP---SMSLFISMTDAIIYEMHIRDFT 233 Query: 206 ISSHEGKVASYKH------------FTCNVLPRIKGLGYNCIQLMAIMEHAY-------- 245 I G K+ T L IK LG +QLM + + Sbjct: 234 IHHESGVRQKGKYVGLTERGTTGPNGTLTGLSYIKQLGVTHVQLMPVQDFEGVDELQPLK 293 Query: 246 YASFGYQITSFFAASSRYGTPEE--------LQELVDTAHSMGIIVLLDVVHSHASKNSA 297 ++GY + A Y T + L+ + GI V+LDVV++H Sbjct: 294 MYNWGYNTVHYNAPEGSYATDPDDPYARIIELKRAIRAFQQEGIRVILDVVYNHVYVRET 353 Query: 298 DGLNMFDGTDSCYFHSGPRGTHDLWDS--RLFAYSSWEILRFLLSNIRWWLEEYRFDGFR 355 YF G A + +F++ ++ +WL+EY DGFR Sbjct: 354 SSFEHLVP--GYYFRYERNGYPSNGTGVGNDLASERKMVKKFIIDSVTYWLKEYGVDGFR 411 Query: 356 FD 357 FD Sbjct: 412 FD 413 >2VNC-A nrPDB Length = 718 Score = 195 bits (494), Expect = 7e-50, Method: Composition-based stats. Identities = 93/478 (19%), Positives = 161/478 (33%), Gaps = 111/478 (23%) Query: 82 ADGGLYCKEWAPGAEGV--FLTGDFNGWNPFSYPYKKLDYG-KWELYIPP-KQNKSVLVP 137 D G+ ++ AE V L N P K G W +++P + + Sbjct: 27 DDDGVNFSLFSENAEKVELLLYSLTNQKYPKEIIEVKNKTGDIWHVFVPGLRPGQLYAYR 86 Query: 138 HGSKLKVVITSKSGEILYRISPWAKYV---------------VREGDNVNYD-------- 174 K + + I P+AK + + ++ YD Sbjct: 87 VYGPYKPELGLRFNPNKVLIDPYAKAINGSVIWNDAVFGYKIGDQNQDLTYDERDSGEYV 146 Query: 175 --------WIHWDPEHSYEFKHSRPKKPRSLRIYESHVGISS------HEGKVASYKHFT 220 + WD E +F + + IYE HV + E +Y+ Sbjct: 147 PKSVVINPYFEWDDE---DFIKGKKVPLKDTVIYEVHVKGFTKLRLDLPENIRGTYEGLA 203 Query: 221 -CNVLPRIKGLGYNCIQLMAIM---------EHAYYASFGYQITSFFAASSRY------- 263 ++ +K LG ++LM + + +GY +FF+ RY Sbjct: 204 SEQMISYLKDLGITTVELMPVFHFIDQRFLTDKGLTNYWGYDPINFFSPECRYSSTGCLG 263 Query: 264 GTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNM-FDGTDS-CYFHSGPRGTHDL 321 G +++V+ H+ GI V++DVV++H ++ + G + F G D+ Y+ P Sbjct: 264 GQVLSFKKMVNELHNAGIEVIIDVVYNHTAEGNHLGPTLSFRGIDNTAYYMLQPDNKRYY 323 Query: 322 WD----SRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDY 377 D S +++ +L ++R+W+ E DGFRFD ++ + V Sbjct: 324 LDFTGTGNTLNLSHPRVIQMVLDSLRYWVTEMHVDGFRFDLAAALARELYSVN------- 376 Query: 378 SEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGG-----FD 432 + N L D I S + + P G GG F Sbjct: 377 -----------------MLNTFFIALQQDPIL-----SQVKLIAEPWDVGQGGYQVGNFP 414 Query: 433 YRLAMAIPDKWIQLLKEF-KDEDWNMGDIVYTLT--------NRRYLEKCIAYAESHD 481 Y+ A K+ ++ F + E +I L N + I Y SHD Sbjct: 415 YQWA-EWNGKYRDSIRRFWRGEALPYSEIANRLLGSPDIYLGNNKTPFASINYVTSHD 471 >3M07-A nrPDB Length = 618 Score = 195 bits (494), Expect = 7e-50, Method: Composition-based stats. Identities = 61/293 (20%), Positives = 110/293 (37%), Gaps = 38/293 (12%) Query: 74 ESFGVHRCADGGLYCKEWAPGAEGVFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKS 133 +S+G A + + WA G + V L + G + L + Sbjct: 32 KSWGAEYIAADVVRFRLWATGQQKVMLRLA-----GKDQEMQANGDGWFTLDVAG----- 81 Query: 134 VLVPHGSKLKVVITSKSGEILYRISPWAKYVVREGDN----VNYDWIHWDPEHSYEFKHS 189 V G++ V++ + P ++ + + V+ W + Sbjct: 82 --VTPGTEYNFVLSDG----MVVPDPASRAQKTDVNGPSYVVDPGSYTWRNTGWKGSRWE 135 Query: 190 RPKKPRSLRIYESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASF 249 + +YE H G + EG + LP + LG I++M + + + Sbjct: 136 Q------AVVYEMHTGTFTPEGTFRA----AIAKLPYLAELGVTVIEVMPVAQFGGERGW 185 Query: 250 GYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSC 309 GY +A S YGTP++ + +D AH G+ V+LD+V +H N Sbjct: 186 GYDGVLLYAPHSAYGTPDDFKAFIDAAHGYGLSVVLDIVLNHFGPEG----NYLPLLAPA 241 Query: 310 YFHSGPRGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSM 362 +FH + W + + AY + R+++ +WL EY DG RFD + + Sbjct: 242 FFH---KERMTPWGNGI-AYDVDAVRRYIIEAPLYWLTEYHLDGLRFDAIDQI 290 >5A2B-A nrPDB Length = 497 Score = 183 bits (465), Expect = 2e-46, Method: Composition-based stats. Identities = 46/216 (21%), Positives = 71/216 (32%), Gaps = 15/216 (6%) Query: 176 IHWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCI 235 W E Y R YE V + + L IK +G+ I Sbjct: 38 RTWQDERIYFIMVDRFNNGNPKNDYEVDV--HDPKAYHGGDLQGIIDKLDYIKEMGFTAI 95 Query: 236 QLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKN 295 L I + GY I F+ +GT ++ + LV AH + V+LD V +H N Sbjct: 96 WLTPIFANEKGGYHGYWIEDFYKVEEHFGTLDDFKRLVKEAHKRDMKVILDFVVNHTGYN 155 Query: 296 SADGLNMFDGTDSCYFHSGPR--------GTHDLW--DSRLFAYSSWEILRFLLSNIRWW 345 + D +FH + W A + E+ +L +WW Sbjct: 156 HPW---LNDPAKKDWFHEKKDIFNWANQQEVENGWLFGLPDLAQENPEVKTYLFDVAKWW 212 Query: 346 LEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYF 381 ++E DG+R D V + + F Sbjct: 213 IQETDIDGYRLDTVKHVPKWFWDEFAKEVKSVKQDF 248 >3FAW-A nrPDB Length = 877 Score = 180 bits (456), Expect = 2e-45, Method: Composition-based stats. Identities = 69/332 (20%), Positives = 125/332 (37%), Gaps = 59/332 (17%) Query: 76 FGVHRCADGG-LYCKEWAPGAEGVFLT---GDFNGWNPFSYPYKKLDYGKWELYIPPKQN 131 G DG + W+P A+ V + D + P K + G W+ + K Sbjct: 135 LGAVLNQDGSKVEASLWSPSADSVTMIIYDKDNQNRVVATTPLVKNNKGVWQTILDTKLG 194 Query: 132 KSVLVPHGSKLKVVITSKSGEILYRISPWAKYVVREGDNVNYDWIHW-----------DP 180 G I ++ + P+AK + N D I P Sbjct: 195 IKNYT--GYYYLYEIKRGKDKVKI-LDPYAKSLAEWDSNTVNDDIKTAKAAFVNPSQLGP 251 Query: 181 EHSYEFKHSRPKKPRSLRIYESHVGISSH--------EGKVASYKHFTCNVLPRIKGLGY 232 ++ K + K + IYE+HV + + ++ ++ F+ L ++ LG Sbjct: 252 QNLSFAKIANFKGRQDAVIYEAHVRDFTSDQSLDGKLKNQLGTFAAFS-EKLDYLQKLGV 310 Query: 233 NCIQLMAIMEHAY-----------------YASFGYQITSFFAASSRYGTP--------E 267 IQL+ ++ + Y ++GY S+FA S Y Sbjct: 311 THIQLLPVLSYFYVNEMDKSRSTAYTSSDNNYNWGYDPQSYFALSGMYSEKPKDPSARIA 370 Query: 268 ELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFH--SGPRGTHDLWDSR 325 EL++L+ H G+ V+LDVV++H +K +F+ + Y+H + + + Sbjct: 371 ELKQLIHDIHKRGMGVILDVVYNHTAKTY-----LFEDIEPNYYHFMNEDGSPRESFGGG 425 Query: 326 LFAYSSWEILRFLLSNIRWWLEEYRFDGFRFD 357 + R L+ +I++ E++ DGFRFD Sbjct: 426 RLGTTHAMSRRVLVDSIKYLTSEFKVDGFRFD 457 >5M99-B nrPDB Length = 505 Score = 180 bits (456), Expect = 2e-45, Method: Composition-based stats. Identities = 70/376 (18%), Positives = 126/376 (33%), Gaps = 74/376 (19%) Query: 197 LRIYESHV-GISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITS 255 +YE + + +G + + ++ LG + + M E Y GY IT Sbjct: 5 PVVYEIFIRSLYDSDGDGVGDINGVSQKVDYLRKLGIDAVWFMPFNEAVSY--HGYDITD 62 Query: 256 FFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYF---- 311 ++ YGT E+L+ ++ H GI V++D+V +H S + + T S + Sbjct: 63 YYNVEKDYGTMEDLENMIQVLHENGIKVIMDLVINHTSDEHPWFKDAVENTTSSPYWDYY 122 Query: 312 ------HSGPRGTH--------DLWDSRLFAYSSWE-------ILRFLLSNIRWWLEEYR 350 HSG H +W LF Y+ + + + + +W+ + Sbjct: 123 IMSLEDHSGQDHWHWKINSKGQKVWYFGLFGYNMPDLNHDSQKVREEVKKIVDFWISK-G 181 Query: 351 FDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITI 410 DGFR D + G S +Y E+F V + PD+I + Sbjct: 182 VDGFRIDAAKHIYGWSWDDGIQESAEYFEWF---------------RDYVLSKKPDAILV 226 Query: 411 AEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNMGDIVYTLTNRRYL 470 E S G Y L++ P + ++ G + ++ Sbjct: 227 GEVFS--------------GNTYDLSL-YPIPVFNFALMYSIRNYPEGQ--DGMIENNWV 269 Query: 471 EKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGL 530 E+ + E+HD F+ E Y S + + + + L Sbjct: 270 EESFLFLENHD-------LHRFFSHLQEHYKKFSE-----SDYEFIKKRAALWYFLIFTL 317 Query: 531 GGEGYLNFMGNEFGHP 546 G + + G E G Sbjct: 318 KGSPVI-YYGGEIGTR 332 >2YA2-A nrPDB Length = 708 Score = 180 bits (456), Expect = 2e-45, Method: Composition-based stats. Identities = 61/335 (18%), Positives = 117/335 (34%), Gaps = 58/335 (17%) Query: 75 SFGVHRCADGG-LYCKEWAPGAEGVFLTGDFNGWNPF---SYPYKKLDYGKWELYIPPKQ 130 G +G + W+P A+ V + + +K + G W+ + Sbjct: 15 KLGADLKEEGKQVDLTLWSPSADKVSVVVYDKNDPDKVVGTVALEKGERGTWKQTLDSTN 74 Query: 131 NKSVLVPHGSKLKVVITSKSGEILYRISPWAKY-VVREGDNVNYDWIH------------ 177 + G + I + G+ + + P+AK D+ D H Sbjct: 75 KLGITDFTGYYYQYQI-ERQGKTVLALDPYAKSLAAWNSDDSKIDDAHKVAKAAFVDPAK 133 Query: 178 WDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYK-------HFTCNVLPRIKGL 230 P+ K K IYE+HV + + +A L +K L Sbjct: 134 LGPQDLTYGKIHNFKTREDAVIYEAHVRDFTSDPAIAKDLTKPFGTFEAFIEKLDYLKDL 193 Query: 231 GYNCIQLMAI------------------MEHAYYASFGYQITSFFAASSRYGTP------ 266 G IQL+ + ++GY ++F+ + Y + Sbjct: 194 GVTHIQLLPVLSYYFVNELKNHERLSDYASSNSNYNWGYDPQNYFSLTGMYSSDPKNPEK 253 Query: 267 --EELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFH--SGPRGTHDLW 322 E + L++ H G+ +LDVV++H +K +++F+ + Y+H + Sbjct: 254 RIAEFKNLINEIHKRGMGAILDVVYNHTAK-----VDLFEDLEPNYYHFMDADGTPRTSF 308 Query: 323 DSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFD 357 + R L+ +I++ ++ Y+ DGFRFD Sbjct: 309 GGGRLGTTHHMTKRLLIDSIKYLVDTYKVDGFRFD 343 >4E2O-A nrPDB Length = 454 Score = 180 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 47/206 (22%), Positives = 78/206 (37%), Gaps = 19/206 (9%) Query: 174 DWIHWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYKHFTCNVLPRIKGLGYN 233 + W E Y R + +V ++ +G L IK +G+ Sbjct: 3 EERTWQDEAIYFIMVDRFNNMDPTN--DQNVNVNDPKGYFGGDLKGVTAKLDYIKEMGFT 60 Query: 234 CIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHAS 293 I L I ++ GY I F+ +GT +L+ LV AH + V+LD V +H Sbjct: 61 AIWLTPIFKNMPGGYHGYWIEDFYQVDPHFGTLGDLKTLVKEAHKRDMKVILDFVANHVG 120 Query: 294 KNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRL------------FAYSSWEILRFLLSN 341 N + D T +FH P+ W+ + A + E+ +L+ Sbjct: 121 YNHPW---LHDPTKKDWFH--PKKEIFDWNDQTQLENGWVYGLPDLAQENPEVKTYLIDA 175 Query: 342 IRWWLEEYRFDGFRFDGVTSMLYHHH 367 +WW++E DG+R D V + Sbjct: 176 AKWWIKETDIDGYRLDTVRHVPKSFW 201 >4OKD-A nrPDB Length = 840 Score = 174 bits (440), Expect = 2e-43, Method: Composition-based stats. Identities = 75/364 (20%), Positives = 127/364 (34%), Gaps = 72/364 (19%) Query: 76 FGVHRCAD-GGLYCKEWAPGAEGVFLTG----DFN-GWNPFSYP---YKKLDYGKWELYI 126 G AD G + ++ AE V L D N G F P Y W + + Sbjct: 65 LGASIDADTGAINFSVFSSSAESVSLVLFTEADLNAGRATFEIPLDPYVNRTGDVWHIML 124 Query: 127 PP-KQNKSVLVPHGSKLKVVITSKSGEILYR----ISPWAKYVVRE------------GD 169 P + + + G + + P+A V+ G+ Sbjct: 125 PDLRDDLLYGYRVEGVHQEEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGE 184 Query: 170 NVNYDWIHWDPEHS------------YEFKHSRPKKPRSLRIYESHVGISSHEGKVA--- 214 + P+ + +E SL IYE+HV + Sbjct: 185 EGVLGVMPTWPQAAAALPAARGSAFDWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAA 244 Query: 215 -SYKHFTCNVLPRIKGLGYNCIQLMAIMEHA--------------YYASFGYQITSFFAA 259 L +K LG N I+L+ + E + +GY ++F+ Sbjct: 245 PGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSP 304 Query: 260 SSRY-----------GTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNM-FDGTD 307 R+ + +E ++LV H GI V+LDVV +H ++ + G + F G D Sbjct: 305 MGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHTAEGNERGPTISFRGLD 364 Query: 308 SC-YFHSGPRGTHDLWDS--RLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLY 364 + Y+ P G + + + + +F+L ++ W+ EY DGFRFD + S+L Sbjct: 365 NRVYYMLAPGGEYYNYSGCGNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFD-LASILT 423 Query: 365 HHHG 368 H Sbjct: 424 RAHS 427 >5ZCD-A nrPDB Length = 555 Score = 169 bits (427), Expect = 4e-42, Method: Composition-based stats. Identities = 89/515 (17%), Positives = 174/515 (33%), Gaps = 64/515 (12%) Query: 195 RSLRIYESHVGIS-SHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQI 253 + Y+ + G + L + LG + I + I + + GY I Sbjct: 7 KEAVAYQIYPRSFMDSNGDGIGDIQGVISKLDYLSDLGIDVIWICPIYQSPNDDN-GYDI 65 Query: 254 TSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCY--- 310 + + +GT E+ EL+D H G+ +++D+V +H S L ++ Y Sbjct: 66 SDYKDIMKDFGTMEDFDELLDEVHHRGMKLIMDLVINHTSDEHPWFLESRSAKENPYRDY 125 Query: 311 --FHSGPRGTHDLWDSRLFAYSSWE--------------------------ILRFLLSNI 342 +H G G +F+ S+WE + L + Sbjct: 126 YIWHEGKDGKEPNNWESIFSGSAWEFDEKTKEYYMHVFSKKQPDLNWENEKVRHELYEMV 185 Query: 343 RWWLEEYRFDGFRFDGVTSM--LYHHHGVGQGFSGDYSEYFGLQVDEDALT-YLMLANHL 399 WWL++ DGFR D ++ + + + DY F ++ + +L Sbjct: 186 NWWLDK-GIDGFRVDAISHIKKVAGFPDLPNPEKLDYVPSFEGHMNRPGIQEHLKELKEK 244 Query: 400 VHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDW-NMG 458 D +T+ + +G+ + + G ++ + + E K D + Sbjct: 245 TFAKY-DIMTVGQ-ANGVTSDSADEWVAEDGGNFNMIFQFEHMGLWDKGEEKPLDLIELK 302 Query: 459 DIVYTLTN--RRYLEKCIAYAESHDQALVGDK--SLAFWLMDAEMYTNMSVLTPFTPVID 514 I+ N + Y E+HDQ +K S A+ + A+ + L TP I Sbjct: 303 TILTNWQNGLEKINGWNALYLENHDQIRSVNKFGSTAYRVESAKCLAALYFLMKGTPFIY 362 Query: 515 RGIQL--HKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGNNESYHYARRQFHLTDD 572 +G +L + G +N+ ++ +S+ + T Sbjct: 363 QGQELGMTNVKFDSIDDYDDVGMINYYRI-----------QREKGDSHDEIMKVIWETGR 411 Query: 573 DLLRYKFLNNFDRDMNRLEERYGWLAAPQAYVSEKHEGNKIIAFERAGLLFIFNFHPSKS 632 D R N +++ W+ YV E K + + NF+ Sbjct: 412 DNSRTPMQWNTEKNA-GFSTGNPWMKVNPNYVDINVEEQK------SDKNSVLNFYKQLI 464 Query: 633 YTDYRVGTALPGKFKIVLDSDAAEYGGHQRLDHST 667 + + G +K++ + D+A Y + L+ T Sbjct: 465 KIRKQHDVLVYGTYKLLAEEDSAIYAYTRTLEGKT 499 >2WSK-A nrPDB Length = 657 Score = 167 bits (422), Expect = 2e-41, Method: Composition-based stats. Identities = 91/554 (16%), Positives = 175/554 (31%), Gaps = 91/554 (16%) Query: 76 FGVHRCADG-GLYCKEWAPGAEGVFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSV 134 G H DG G+ ++ AE V L Y W Y+P + Sbjct: 12 LGAHY--DGQGVNFTLFSAHAERVELCVFDANGQEHRYDLPGHSGDIWHGYLPDAR---- 65 Query: 135 LVPHGSKLKVVITSKS--------GEILYRISPWAKYVV------------------REG 168 G + + I P A+ + R+ Sbjct: 66 ---PGLRYGYRVHGPWQPAEGHRFNPAKLLIDPCARQIDGEFKDNPLLHAGHNEPDYRDN 122 Query: 169 DNVNYDWIHWDPEHSYEFKHSRPKKPRSLRIYESHV-GISSHEGKV-----ASYKHFTCN 222 + + + +E S IYE+HV G++ ++ +YK Sbjct: 123 AAIAPKCVVVVDHYDWEDDAPPRTPWGSTIIYEAHVKGLTYLHPEIPVEIRGTYKALGHP 182 Query: 223 -VLPRIKGLGYNCIQLMAIMEHAYY---------ASFGYQITSFFAASSRYG-----TPE 267 ++ +K LG ++L+ + + A +GY + FA Y + Sbjct: 183 VMINYLKQLGITALELLPVAQFASEPRLQRMGLSNYWGYNPVAMFALHPAYACSPETALD 242 Query: 268 ELQELVDTAHSMGIIVLLDVVHSHASKNSADG-LNMFDGTDS-CYFHSGPRGTHDLW--D 323 E ++ + H GI V+LD+V +H+++ DG L G D+ Y+ G + W Sbjct: 243 EFRDAIKALHKAGIEVILDIVLNHSAELDLDGPLFSLRGIDNRSYYWIREDGDYHNWTGC 302 Query: 324 SRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGL 383 S ++ + + +R+W+E DGFRFD M G F D + + Sbjct: 303 GNTLNLSHPAVVDYASACLRYWVETCHVDGFRFDLAAVM-----GRTPEFRQDAPLFTAI 357 Query: 384 QVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKW 443 Q ++A + P + F + + Sbjct: 358 QNCPVLSQVKLIAEPW--DIAPGGYQVGNFPPLFAEWNDHFRDAARRFWLHYDLPLGAFA 415 Query: 444 IQLLKE----FKDEDWNMGDI-VYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAE 498 + ++ I + T + L C+ + H++A G+++ + Sbjct: 416 GRFAASSDVFKRNGRLPSAAINLVTAHDGFTLRDCVCFNHKHNEA-NGEENRDGTNNNYS 474 Query: 499 MYTNMSVLTPFTPVIDRGI-QLHKMIRLITHGLGGEGYLNFMGNEFGHPE---------- 547 L +++R +H ++ + G + G+E GH + Sbjct: 475 NNHGKEGLGGSLDLVERRRDSIHALLTTLLLSQGTP--MLLAGDEHGHSQHGNNNAYCQD 532 Query: 548 ----WLDFPRKGNN 557 WLD+ + + Sbjct: 533 NQLTWLDWSQASSG 546 >1J0H-A nrPDB Length = 588 Score = 166 bits (419), Expect = 4e-41, Method: Composition-based stats. Identities = 71/429 (16%), Positives = 132/429 (30%), Gaps = 95/429 (22%) Query: 208 SHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPE 267 + + L + LG I L I ++ Y +F +G E Sbjct: 166 TPTSFFGGDLQGIIDHLDYLVDLGITGIYLTPIFRSP--SNHKYDTADYFEVDPHFGDKE 223 Query: 268 ELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSC----YFH-------SGPR 316 L+ L+D H GI V+LD V +H A +++ +S +FH + PR Sbjct: 224 TLKTLIDRCHEKGIRVMLDAVFNHCGYEFAPFQDVWKNGESSKYKDWFHIHEFPLQTEPR 283 Query: 317 GTHDLW----DSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQG 372 +D + ++ E+ R+LL +W+ E+ DG+R D + Sbjct: 284 PNYDTFAFVPQMPKLNTANPEVKRYLLDVATYWIREFDIDGWRLDVANEI---------- 333 Query: 373 FSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAE---DVSGMPALCSPISQGGG 429 + V L PD + E D G Sbjct: 334 ----------------DHEFWREFRQEVKALKPDVYILGEIWHDAMPW--------LRGD 369 Query: 430 GFDYRLAMAIPDKWIQLLKEFKDEDWNMGDIVYTLTNRR---YLEKCIAYAESHDQALVG 486 FD + D ++ + + + + + + E SHD + Sbjct: 370 QFDAVMNYPFTDGVLRFFAKEEISARQFANQMMHVLHSYPNNVNEAAFNLLGSHDTS--- 426 Query: 487 DKSLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHP 546 V I+ K++ L G + + G+E G Sbjct: 427 ---------------------RILTVCGGDIRKVKLLFLFQLTFTGSPCI-YYGDEIG-- 462 Query: 547 EWLDFPRKGNNESYHYARRQFHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAAPQ-AYVS 605 G N+ + + D + + K L+ + + L ++Y L + +++ Sbjct: 463 ------MTGGNDP----ECRKCMVWDPMQQNKELHQHVKQLIALRKQYRSLRRGEISFLH 512 Query: 606 EKHEGNKII 614 E N +I Sbjct: 513 ADDEMNYLI 521 >5OT1-A nrPDB Length = 765 Score = 166 bits (419), Expect = 4e-41, Method: Composition-based stats. Identities = 71/397 (17%), Positives = 134/397 (33%), Gaps = 70/397 (17%) Query: 212 KVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQE 271 L ++ LG I + I ++ GY ++ ++GT +EL+E Sbjct: 346 YFGGDIKGITEKLDYLQSLGVTIIYINPIFLSG--SAHGYDTYDYYRLDPKFGTEDELRE 403 Query: 272 LVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHS-----------GPRGTHD 320 +D AH G+ V+ D V +H + L++++ + + G + Sbjct: 404 FLDEAHRRGMRVIFDFVPNHCGIGNPAFLDVWEKGNESPYWDWFFVKKWPFKLGDGSAYV 463 Query: 321 LW----DSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGD 376 W ++ E+ +L+ W+ E+ FDG R D +L Sbjct: 464 GWWGFGSLPKLNTANQEVREYLIGAALHWI-EFGFDGIRVDVPNEVL------------- 509 Query: 377 YSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLA 436 D T+ V PD+ + E + SP G FD + Sbjct: 510 -----------DPGTFFPELRKAVKEKKPDAYLVGEIWT-----LSPEWVKGDRFDSLMN 553 Query: 437 MAIPDKWIQLLKEFKDEDWNMGDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMD 496 A+ +L + + G+ + R Y Y E+ + +L Sbjct: 554 YALG---RDILLNY-AKGLLSGESAMKMMGRYYAS----YGEN---VVAMGFNLVDSHDT 602 Query: 497 AEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGN 556 + + T++ + IQ K++ + + L G F G+E G G+ Sbjct: 603 SRVLTDLGGGKLGDTPSNESIQRLKLLSTLLYALPGTPV-TFQGDERG--------LLGD 653 Query: 557 NESYHYARR--QFHLTDDDLLR-YKFLNNFDRDMNRL 590 Y R Q+ ++D+L Y+ L + + L Sbjct: 654 KGHYDEQRYPIQWDTVNEDVLNHYRALAELRKRVPAL 690 Score = 34.8 bits (78), Expect = 0.15, Method: Composition-based stats. Identities = 24/116 (20%), Positives = 34/116 (29%), Gaps = 25/116 (21%) Query: 94 GAEGVFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGSKLKVVITSKSGEI 153 + V L G FN W +P + L G WE + L P + K I + + Sbjct: 98 TVKSVSLRGSFNNWG--EWPME-LKNGTWETTV-------CLRPGRYEYKYFINGQW--V 145 Query: 154 LYRIS-----PW-----AKYVVREGDNVNYDWIHWDPEHSYEFKHSRPKKPRSLRI 199 P+ A G + EF P+ P L I Sbjct: 146 KDMSDDGTGRPYDPDADAYAPDGYGGKNAVRVVEGREAFYVEFD---PRDPAYLSI 198 >1WZA-A nrPDB Length = 488 Score = 164 bits (416), Expect = 8e-41, Method: Composition-based stats. Identities = 50/215 (23%), Positives = 83/215 (38%), Gaps = 32/215 (14%) Query: 205 GISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYG 264 GI +G + + I LG N I LM I + Y GY +T ++ + YG Sbjct: 22 GIGDLKGIIEKLDYLNDGDPETIADLGVNGIWLMPIFKSPSY--HGYDVTDYYKINPDYG 79 Query: 265 TPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCY-------------- 310 T E+ +LV+ AH GI V++D+ +H S+ L +S Y Sbjct: 80 TLEDFHKLVEAAHQRGIKVIIDLPINHTSERHPWFLKASRDKNSEYRDYYVWAGPDTDTK 139 Query: 311 ---------FHSGPRGTHDLW---DSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDG 358 +H P G + + Y++ E+ ++ ++WL++ DGFR DG Sbjct: 140 ETKLDGGRVWHYSPTGMYYGYFWSGMPDLNYNNPEVQEKVIGIAKYWLKQ-GVDGFRLDG 198 Query: 359 VTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYL 393 + E F +++E YL Sbjct: 199 AMHIFPPAQYDKNFTWW---EKFRQEIEEVKPVYL 230 >1SMA-A nrPDB Length = 588 Score = 162 bits (409), Expect = 5e-40, Method: Composition-based stats. Identities = 96/546 (17%), Positives = 159/546 (29%), Gaps = 123/546 (22%) Query: 102 GDFNGWNPF-SYPYKKLDYGKW------ELYIPPKQNKSVLVPHGSKLKVVITSKSGEIL 154 G F+ W PY++L YG +L K + L Sbjct: 66 GLFDYWLAEVKPPYRRLRYGFVLRAGGEKLVYTEKGFYHEAPSDDTAYYFCFPFLHRVDL 125 Query: 155 YRISPWAKYVVREGDNVNYDWIHWDPEHSYEFKHSRPK-KPRSLRIYESHVGISSHEGKV 213 ++ W K V W PE F + P P+ R + S + Sbjct: 126 FQAPDWVKDTV---------WYQIFPER---FANGNPAISPKGARPWGSE--DPTPTSFF 171 Query: 214 ASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELV 273 + L + LG I L I ++ Y +F +G E L+ LV Sbjct: 172 GGDLQGIIDHLDYLADLGITGIYLTPIFRAP--SNHKYDTADYFEIDPHFGDKETLKTLV 229 Query: 274 DTAHSMGIIVLLDVVHSHASKNSADGLNMFDG----TDSCYFH-------SGPRGTHDLW 322 H GI V+LD V +H A ++ +FH + PR +D + Sbjct: 230 KRCHEKGIRVMLDAVFNHCGYEFAPFQDVLKNGAASRYKDWFHIREFPLQTEPRPNYDTF 289 Query: 323 D----SRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYS 378 + E+ R+LL +W+ E+ DG+R D + Sbjct: 290 AFVPHMPKLNTAHPEVKRYLLDVATYWIREFDIDGWRLDVANEI---------------- 333 Query: 379 EYFGLQVDEDALTYLMLANHLVHTLCPDSITIAE---DVSGMPALCSPISQGGGGFDYRL 435 + V L PD + E D G FD + Sbjct: 334 ----------DHQFWREFRQAVKALKPDVYILGEIWHDAMPW--------LRGDQFDAVM 375 Query: 436 AMAIPDKWIQLLKEFKDEDWNMGDIVYTLTN--RRYL----EKCIAYAESHDQALVGDKS 489 + D ++ F ED + + L + Y E SHD Sbjct: 376 NYPLADAALRF---FAKEDMSASEFADRLMHVLHSYPKQVNEAAFNLLGSHDTP------ 426 Query: 490 LAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEWL 549 V ++ K++ L G + + G+E G Sbjct: 427 ------------------RLLTVCGGDVRKVKLLFLFQLTFTGSPCI-YYGDEIG----- 462 Query: 550 DFPRKGNNESYHYARRQFHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAAPQ-AYVSEKH 608 G N+ + + D + K L + + L ++Y L A+++ Sbjct: 463 ---MTGGNDP----ECRKCMVWDPEKQNKELYEHVKQLIALRKQYRALRRGDVAFLTADD 515 Query: 609 EGNKII 614 E N ++ Sbjct: 516 EVNHLV 521 >5BRQ-A nrPDB Length = 568 Score = 156 bits (394), Expect = 3e-38, Method: Composition-based stats. Identities = 80/464 (17%), Positives = 149/464 (32%), Gaps = 72/464 (15%) Query: 195 RSLRIYESHVGIS-SHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQI 253 + +Y+ + G L IK L + I L I + + GY I Sbjct: 16 KKAVVYQIYPKSFKDTTGNGVGDIRGIIEKLDYIKELACDVIWLTPIYQSPQNDN-GYDI 74 Query: 254 TSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCY--- 310 + +++ YGT + +EL++ AH GI V++D+V +H S G ++ Y Sbjct: 75 SDYYSIHEEYGTMADFEELLEEAHKRGIKVIMDLVVNHTSTEHRWFKEAASGKENLYRDF 134 Query: 311 --------------------------FHSGPRGTH---DLWDSRLFAYSSWEILRFLLSN 341 FH+ + + + + + + Sbjct: 135 YIWKDMKPNGAPPTNWESKFGGSAWEFHAESGQYYLHLYDVTQADLNWENEAVRKKVYEM 194 Query: 342 IRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVH 401 + +W E+ DGFR D + ++ GD ++ +L N V Sbjct: 195 MHFWFEK-GIDGFRLDVIN-VISKDQRFPDDDEGDGRRFYTD--GPRVHEFLNEMNREVF 250 Query: 402 TLCPDSITIAEDVSGMPALC-SPISQGGGGFDYRLAMAIPDKWIQLLKEFKD-EDWNMGD 459 + DS+T+ E S A C + D L ++ + E W + D Sbjct: 251 SKY-DSMTVGEMSSTTIADCIRYTNPESRELDMVFNFH------HLKADYPNGEKWALAD 303 Query: 460 IVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGIQL 519 + + E + G + FW + +++ + + Sbjct: 304 FDFLKLKKILSEWQTEMNKG------GGWNALFWCNHDQPR----IVSRYGDDGKYRKKS 353 Query: 520 HKMIRLITHGLGGEGYLNFMGNEFG--HPEWLDFPRKGNNESYHYARRQFHLTDDDLLRY 577 KM+ H L G Y+ + G E G +P++ D + ES + R + Sbjct: 354 AKMLATAIHMLQGTPYI-YQGEELGMTNPKFDDISLYRDVESLNMYRILKEAGKPEAEII 412 Query: 578 KFLNNFDRDMNRLEERY------------GWLAAPQAYVSEKHE 609 + L RD +R ++ W+ P Y E Sbjct: 413 EILKAKSRDNSRTPVQWNGEENAGFTAGTPWIPVPDNYKEINAE 456 >2ZE0-A nrPDB Length = 555 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 55/333 (16%), Positives = 103/333 (30%), Gaps = 44/333 (13%) Query: 205 GISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYG 264 G L + LG + + + I + GY I+ ++A +G Sbjct: 18 SFMDANGDGIGDLRGIIEKLDYLVELGVDIVWICPIYRSPNADN-GYDISDYYAIMDEFG 76 Query: 265 TPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDS-----CYFHSGPRGTH 319 T ++ EL+ AH G+ V+LD+V +H S + D+ + G G Sbjct: 77 TMDDFDELLAQAHRRGLKVILDLVINHTSDEHPWFIESRSSRDNPKRDWYIWRDGKDGRE 136 Query: 320 -DLWDS-------------------------RLFAYSSWEILRFLLSNIRWWLEEYRFDG 353 + W+S + + E+ + L + WWL++ DG Sbjct: 137 PNNWESIFGGSAWQYDERTGQYYLHIFDVKQPDLNWENSEVRQALYEMVNWWLDK-GIDG 195 Query: 354 FRFDGVTSM---LYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITI 410 FR D ++ + + G + YL D +T+ Sbjct: 196 FRIDAISHIKKKPGLPDLPNPKGLKYVPSFAGHMNQPGIMEYLRELKEQTFARY-DIMTV 254 Query: 411 AEDVSGMPALCSPISQG--GGGFDYRLAMAIPDKWIQLLKEFKDEDWNMGDIVYTLTNRR 468 E +G+ + G G F+ W + D + Sbjct: 255 GE-ANGVTVDEAEQWVGEENGVFNMIFQFEHLGLWERRADGSIDVRRLKRTLTKWQKGLE 313 Query: 469 YLEKCIAYAESHDQALVGDKSLAFWLMDAEMYT 501 + E+HD +S++ W D + + Sbjct: 314 NRGWNALFLENHD----LPRSVSTWGNDRDYWA 342 >1UOK-A nrPDB Length = 558 Score = 148 bits (374), Expect = 6e-36, Method: Composition-based stats. Identities = 75/469 (15%), Positives = 152/469 (32%), Gaps = 82/469 (17%) Query: 195 RSLRIYESHVGIS-SHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQI 253 + +Y+ + G + L +K LG + I L + E + GY I Sbjct: 7 KESVVYQIYPRSFMDSNGDGIGDLRGIISKLDYLKELGIDVIWLSPVYESPNDDN-GYDI 65 Query: 254 TSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCY--- 310 + + + +GT E+ EL+ H + +++D+V +H S + D+ Y Sbjct: 66 SDYCKIMNEFGTMEDWDELLHEMHERNMKLMMDLVVNHTSDEHNWFIESRKSKDNKYRDY 125 Query: 311 --FHSGPRGTH-DLWDSR-------------------------LFAYSSWEILRFLLSNI 342 + G G + W + + + ++ + + + Sbjct: 126 YIWRPGKEGKEPNNWGAAFSGSAWQYDEMTDEYYLHLFSKKQPDLNWDNEKVRQDVYEMM 185 Query: 343 RWWLEEYRFDGFRFDGVTSMLYHH--HGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLV 400 ++WLE+ DGFR D + + V G S + + YL N V Sbjct: 186 KFWLEK-GIDGFRMDVINFISKEEGLPTVETEEEGYVSGHKHFMNGPNIHKYLHEMNEEV 244 Query: 401 HTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNMGDI 460 + D +T+ E MP + + + +L K +Q++ +F+ D + G+ Sbjct: 245 LSHY-DIMTVGE----MPGVTTE--------EAKLYTGEERKELQMVFQFEHMDLDSGE- 290 Query: 461 VYTLTNRRYLEKCIAYAESHD------QALVGDKSLAFWLMDAEMYTNMSVLTPFTPVID 514 + ++ C + + +W + V++ F Sbjct: 291 ----GGKWDVKPCSLLTLKENLTKWQKALEHTGWNSLYWNNHDQPR----VVSRFGNDGM 342 Query: 515 RGIQLHKMIRLITHGLGGEGYLNFMGNEFGHP----EWLDFPR------------KGNNE 558 I+ KM+ + H + G Y+ + G E G E +D R E Sbjct: 343 YRIESAKMLATVLHMMKGTPYI-YQGEEIGMTNVRFESIDEYRDIETLNMYKEKVMERGE 401 Query: 559 SYHYARRQFHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAAPQAYVSEK 607 + ++ D R + D++ W+ Y Sbjct: 402 DIEKVMQSIYIKGRDNARTPMQWD-DQNHAGFTTGEPWITVNPNYKEIN 449 >5WCZ-A nrPDB Length = 586 Score = 148 bits (373), Expect = 8e-36, Method: Composition-based stats. Identities = 63/396 (15%), Positives = 122/396 (30%), Gaps = 73/396 (18%) Query: 195 RSLRIYESH-VGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQI 253 + +Y+ + G L IK LG + I L + + + GY I Sbjct: 31 KEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGADVIWLSPVFDSPQDDN-GYDI 89 Query: 254 TSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCY--- 310 + + ++GT E++ +L+D H G+ +++D+V +H S A D+ Y Sbjct: 90 SDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNHTSDEHAWFAESRKSKDNPYRDY 149 Query: 311 ---FHSGPRGTH-DLWDS-------------------------RLFAYSSWEILRFLLSN 341 P G+ + W S + + + R + Sbjct: 150 YLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYLHYFSKKQPDLNWENEAVRREVYDV 209 Query: 342 IRWWLEEYRFDGFRFDGVTSML----YHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLAN 397 +R+W++ DG+R D + S+ + + S Y ++ N Sbjct: 210 MRFWMDR-GVDGWRMDVIGSISKYTDFPDYETDHSRSYIVGRYHS--NGPRLHEFIQEMN 266 Query: 398 HLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDW-- 455 V + D +T+ E +G + + + I + + W Sbjct: 267 REVLSHY-DCMTVGE-ANGSDIEEAKKYTDASRQELNMIFTFEHMDIDKEQNSPNGKWQI 324 Query: 456 -NMGDIVYTLTNRRYLEK------CIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTP 508 I T R+ Y E+HDQ + + Sbjct: 325 KPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQ--------------PRVISRWGNDRK 370 Query: 509 FTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFG 544 + K + HG+ G ++ + G E G Sbjct: 371 L------RKECAKAFATVLHGMKGTPFI-YQGEEIG 399 >1EA9-C nrPDB Length = 583 Score = 147 bits (370), Expect = 2e-35, Method: Composition-based stats. Identities = 54/319 (16%), Positives = 105/319 (32%), Gaps = 51/319 (15%) Query: 208 SHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPE 267 + + L + LG N + + + + Y +F ++G + Sbjct: 162 TPSCFFGGDLQGVIDHLDHLSKLGVNAVYFTPLFKA--TTNHKYDTEDYFQIDPQFGDKD 219 Query: 268 ELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSC----YFHSGPRGTH---- 319 L++LVD H GI VLLD V +H+ + +++ + +FH Sbjct: 220 TLKKLVDLCHERGIRVLLDAVFNHSGRTFPPFVDVLKNGEKSKYKDWFHIRSLPLEVVDG 279 Query: 320 -DLWDSRLF-------AYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQ 371 +D+ F ++ +LL +W+ E DG+R D Sbjct: 280 IPTYDTFAFEPLMPKLNTEHPDVKEYLLKAAEYWIRETGIDGWRLDVA------------ 327 Query: 372 GFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGGF 431 +E + + +V PD+ + E ++ Q Sbjct: 328 --------------NEVSHQFWREFRRVVKQANPDAYILGEVWHE-SSIWLEGDQFDAVM 372 Query: 432 DYRLAMAIPDKWIQLLKEFKDEDWNMGDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLA 491 +Y A+ D +I + + + + +G + R+ E +SHD A L Sbjct: 373 NYPFTNAVLDFFIHQIADAEKFSFMLGKQL-AGYPRQASEVMFNLLDSHDTA-----RLL 426 Query: 492 FWLMDAEMYTNMSVLTPFT 510 + ++VL FT Sbjct: 427 TQADGDKRKMKLAVLFQFT 445 >5DO8-B nrPDB Length = 555 Score = 145 bits (365), Expect = 7e-35, Method: Composition-based stats. Identities = 72/466 (15%), Positives = 139/466 (29%), Gaps = 75/466 (16%) Query: 195 RSLRIYESH-VGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQI 253 + +Y+ + + G L +K LG + I L + + + GY I Sbjct: 8 KKSVVYQIYPKSFNDSNGDGVGDIQGIIEKLDYLKELGVDVIWLSPVYDSPQDDN-GYDI 66 Query: 254 TSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSC---Y 310 + YG +L+ H + +++D+V +H S D+ Y Sbjct: 67 RDYQKIYEEYGDMATFDQLLQGLHDRDMKLVMDLVVNHTSDEHKWFEESRKSKDNPYRDY 126 Query: 311 FHSGPRGTHDLWDS-------------------------RLFAYSSWEILRFLLSNIRWW 345 + + W S + + ++ + + + +++W Sbjct: 127 YFWREENEINNWGSIFSGPAWELDEKTGEYYLHLFSKKQPDLNWENPKLRQDVYNMMKFW 186 Query: 346 LEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVD----EDALTYLMLANHLVH 401 L++ DGFR D + + + G D Y D +L N V Sbjct: 187 LDK-GIDGFRMDVINFI-SKNTDFPDGPVPDGQIYGDAGNDFCNGPRIHEFLQEMNQEVT 244 Query: 402 TLCPDSITIAEDVSGMPALCS---PISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNMG 458 + D +T+ E MP + I + + + D W++ Sbjct: 245 SKY-DVMTVGE----MPGASTTDAQIYTNPANNEVDMIFTFEHMNLD---SDSDNKWDLK 296 Query: 459 DIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGIQ 518 I E +A E+ +L + + + F ++ Sbjct: 297 PIYLPDLKENMSEWQVALQENGWNSLYWNNH-----DQPRIVSRFGNDNRF------RVR 345 Query: 519 LHKMIRLITHGLGGEGYLNFMGNEFG----HPEWLDFP-----------RKGNNESYHYA 563 KM+ H + G Y+ + G E G H E LD RK S+ Sbjct: 346 SAKMLATCLHMMKGTPYI-YQGEEIGMTNVHFETLDDYRDIETLNMYKERKEQGHSHESI 404 Query: 564 RRQFHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAAPQAYVSEKHE 609 + + D R + + + + WL Y +E Sbjct: 405 MQSIYTKGRDNARTPYQWD-NSENAGFTTGTPWLKVNPRYTEINNE 449 >1JL8-A nrPDB Length = 585 Score = 145 bits (365), Expect = 7e-35, Method: Composition-based stats. Identities = 81/495 (16%), Positives = 142/495 (28%), Gaps = 110/495 (22%) Query: 128 PKQNKSVLVPHGSKLKVVITSKSGEILYRISPWAKYVVRE---GDNVNYDWIHWDPEHSY 184 + S + +S ++ WAK V + DP + Sbjct: 97 GETGFSAERSKAGVFQYAYIHRSE--VFTTPEWAKEAVIYQIFPERFANGDPSNDPPGTE 154 Query: 185 EFKHSRPKKPRSLRIYESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHA 244 ++ ++ +PR Y + LP ++ LG + I Sbjct: 155 QW--AKDARPRHDSFY-------------GGDLKGVIDRLPYLEELGVTALYFTPIFASP 199 Query: 245 YYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMF- 303 + Y + A ++G + LVD AH GI ++LD V +HA ++ Sbjct: 200 SH--HKYDTADYLAIDPQFGDLPTFRRLVDEAHRRGIKIILDAVFNHAGDQFFAFRDVLQ 257 Query: 304 -----DGTDSCYFHSGPRGTHDLWDSRLFA----------YSSWEILRFLLSNIRWWLEE 348 D + P + FA + E+ +L R+W+E+ Sbjct: 258 KGEQSRYKDWFFIEDFPVSKTSRTNYETFAVQVPAMPKLRTENPEVKEYLFDVARFWMEQ 317 Query: 349 YRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSI 408 DG+R + +E + LV +L PD++ Sbjct: 318 -GIDGWRLNVA--------------------------NEVDHAFWREFRRLVKSLNPDAL 350 Query: 409 TIAE---DVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNMGDIVYTLT 465 + E D SG G FD + + I+ + G+I Sbjct: 351 IVGEIWHDASGW--------LMGDQFDSVMNYLFRESVIRF--------FATGEIHAERF 394 Query: 466 NRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRL 525 + + Y E QA G +L T+ + +L + ++ Sbjct: 395 DAELTRARMLYPE---QAAQGLWNLLDSHDTERFLTSCG-------GNEAKFRLAVLFQM 444 Query: 526 ITHGLGGEGYLNFMGNEFGHPEWLD--------FPRKGNN----ESYHYARRQFHLTDDD 573 G L + G+E G D + K N E Y R H Sbjct: 445 TYLGTP----LIYYGDEIGMAGATDPDCRRPMIWEEKEQNRGLFEFYKELIRLRHRLASL 500 Query: 574 LLRYKFLNNFDRDMN 588 + D+ N Sbjct: 501 TRGNVRSWHADKQAN 515 >4GKL-A nrPDB Length = 422 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 46/185 (24%), Positives = 81/185 (43%), Gaps = 17/185 (9%) Query: 193 KPRSLRIYESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFG-- 250 ++L IYE+ ++ G+ L R+KG+G N + LM I G Sbjct: 2 NLKNLIIYEAFAR--AYPGEKGKKFLSLEKDLERLKGMGINTVWLMPIHPTGVEGRKGTL 59 Query: 251 ---YQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTD 307 Y I ++ GT + ++ V AH + + VL+D+V +HA+ + N+ Sbjct: 60 GSPYAIRDYYEIDLLIGTKGDFKKFVKRAHELNMYVLMDMVLNHAAVD-----NVLVKKH 114 Query: 308 SCYF----HSGPRGTHDLW-DSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSM 362 +F + P W D F YS+ E+ ++++ +R+W+EE+ DGFR D + Sbjct: 115 PEWFLRDENGNPTRKVPDWSDVVDFDYSNGELREYMINMMRYWVEEFDVDGFRCDVAGLV 174 Query: 363 LYHHH 367 Sbjct: 175 PLDFW 179 >2WC7-A nrPDB Length = 488 Score = 142 bits (357), Expect = 5e-34, Method: Composition-based stats. Identities = 68/436 (15%), Positives = 124/436 (28%), Gaps = 78/436 (17%) Query: 180 PEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMA 239 P+ K R + + R +E + + +G L I+ LG N I Sbjct: 19 PDRFARSKQPRKRLLQEAR-WEDWDSMPTLQGYKGGDLWGIMEDLDYIQNLGINAIYFTP 77 Query: 240 IMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADG 299 I + A ++ Y ++ G E +EL+D AH I V+LD V +H+S+ Sbjct: 78 IFQSA--SNHRYHTHDYYQVDPMLGGNEAFKELLDAAHQRNIKVVLDGVFNHSSRGFFFF 135 Query: 300 LNMFD-GTDSCY--------FHSGPRG-----THDLWDSRL----FAYSSWEILRFLLSN 341 ++ + G S + + P + W F + + E+ +++ Sbjct: 136 HDVLENGPHSPWVNWFKIEGWPLSPYNGEFPANYVGWAGNRALPEFNHDNPEVREYIMEI 195 Query: 342 IRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVH 401 +WL+ + DG+R D + + Sbjct: 196 AEYWLK-FGIDGWRLDVPFEI-------------------------KTPGFWQEFRDRTK 229 Query: 402 TLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNMGDIV 461 + P++ + E G FD + I + + + Sbjct: 230 AINPEAYIVGEV---W-GDSRQWLDGT-QFDGVMNYLFAGPTIAFAA---GDRVVLEQVQ 281 Query: 462 YTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVL------TPFTPVIDR 515 YA + L L E+ L + Sbjct: 282 SRDYQPYPPLFAAEYATKIQEVL--------QLYPWEIQLTQLNLLASHDTARLMTIAGG 333 Query: 516 GIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLD------FPRKGNNESYHYARRQFHL 569 I ++ L+ G + + G+E G P +D FP N + L Sbjct: 334 DIASVELSTLLLLTFPGAPSI-YYGDEVGLPGGIDPDSRRGFP-LEANWNQEIFNTHRQL 391 Query: 570 TDDDLLRYKFLNNFDR 585 Y L D Sbjct: 392 I-TIRQTYPALRTGDY 406 >3WY1-A nrPDB Length = 538 Score = 141 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 53/304 (17%), Positives = 90/304 (29%), Gaps = 52/304 (17%) Query: 198 RIYESHVGIS-SHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSF 256 IY+ + G + L + L + I L FGY ++ + Sbjct: 12 VIYQIYPRSFLDSRGDGVGDLNGITEKLDYVASLNVDGIWLSPFFTSPMLD-FGYDVSDY 70 Query: 257 FAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSC------Y 310 +GT E+ + L++ AHS+G+ V++D V SH S + + Sbjct: 71 RDVDPMFGTLEDFKALLEKAHSLGLKVMIDQVISHTSDQHPWFQESRQNRTNPKADWFVW 130 Query: 311 FHSGPRGT-HDLW-------------------------DSRLFAYSSWEILRFLLSNIRW 344 P GT + W + E + L N+R+ Sbjct: 131 ADPKPDGTPPNNWLSIFGGSAWTFDSRRQQYYLHNFLTSQPDVNFHHPEARQAQLDNMRF 190 Query: 345 WLEEYRFDGFRFDGVTSMLYHHH---------------GVGQGFSGDYSEYFGLQVDEDA 389 WL + DGFR D V + G + + + + Sbjct: 191 WL-DLGVDGFRLDTVNFYFHDAELRDNPPVPKGEAKTLGAPEANPYTWQRHVYDLSRPEN 249 Query: 390 LTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKE 449 L +L L+ P + T+ E P L GG +A + Sbjct: 250 LDFLKDLRALMDE-YPGTTTVGEIGDDNP-LERMAEYTAGGDKLHMAYTFDLLNMPHSAS 307 Query: 450 FKDE 453 + E Sbjct: 308 YLRE 311 >1BF2-A nrPDB Length = 750 Score = 139 bits (350), Expect = 4e-33, Method: Composition-based stats. Identities = 68/465 (14%), Positives = 138/465 (29%), Gaps = 95/465 (20%) Query: 75 SFGV-HRCADGGLYCKEWAPGAEGVFLTGDFNGWNPFS---YPYKKLDYGKWELYIPPKQ 130 S G + + + ++ A + L G+ Y G W + +P Sbjct: 6 SLGASYDAQQANITFRVYSSQATRIVLYLYSAGYGVQESATYTLSPAGSGVWAVTVPVSS 65 Query: 131 NKSVLVPHGSKLKVV-------ITSKSGEILYR-------------------ISPWAKYV 164 K+ + S G+ + P+A+ V Sbjct: 66 IKAAGITGAVYYGYRAWGPNWPYASNWGKGSQAGFVSDVDANGDRFNPNKLLLDPYAQEV 125 Query: 165 VREGDN----------VNYDWIHWDP-----------EHSYEFKHSRPKKPRSLRIYESH 203 ++ N + D + + + IYE H Sbjct: 126 SQDPLNPSNQNGNVFASGASYRTTDSGIYAPKGVVLVPSTQSTGTKPTRAQKDDVIYEVH 185 Query: 204 VGISSHEGK-----VASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYAS---------- 248 V + + + + LG ++ + + E A+ Sbjct: 186 VRGFTEQDTSIPAQYRGTYYGAGLKASYLASLGVTAVEFLPVQETQNDANDVVPNSDANQ 245 Query: 249 --FGYQITSFFAASSRY-------GTPEELQELVDTAHSMGIIVLLDVVHSHASKNSAD- 298 +GY ++F+ RY G E Q +V H+ GI V +DVV++H ++ Sbjct: 246 NYWGYMTENYFSPDRRYAYNKAAGGPTAEFQAMVQAFHNAGIKVYMDVVYNHTAEGGTWT 305 Query: 299 -------GLNMFDGTDSCYFHSGPRGTHDLWD----SRLFAYSSWEILRFLLSNIRWWLE 347 + + G D+ ++ G +D F + ++ ++ +W Sbjct: 306 SSDPTTATIYSWRGLDNATYYELTSGNQYFYDNTGIGANFNTYNTVAQNLIVDSLAYWAN 365 Query: 348 EYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDS 407 DGFRFD + + + + ++ + DA + N ++ + Sbjct: 366 TMGVDGFRFDLASVL--GNSCLNGAYTASAPNCPNGGYNFDAADSNVAINRILREF---T 420 Query: 408 ITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKD 452 + A SG+ P + GG + P W + F+D Sbjct: 421 VRPAAGGSGLDLFAEPWAIGGNSYQLG---GFPQGWSEWNGLFRD 462 >1M53-A nrPDB Length = 570 Score = 137 bits (345), Expect = 2e-32, Method: Composition-based stats. Identities = 81/482 (16%), Positives = 148/482 (30%), Gaps = 79/482 (16%) Query: 185 EFKHSRPKKPRSLRIYESHVGIS-SHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEH 243 + + P + Y+ + L +K LG + I + + Sbjct: 11 QKESEYPAWWKEAVFYQIYPRSFKDTNDDGIGDIRGIIEKLDYLKSLGIDAIWINPHYDS 70 Query: 244 AYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMF 303 + GY I+++ YGT E+ LV + +++DVV +H S + Sbjct: 71 PNTDN-GYDISNYRQIMKEYGTMEDFDSLVAEMKKRNMRLMIDVVINHTSDQHPWFIQSK 129 Query: 304 DGTDSCY-----FHSG-----PRGTHDLWDS---------------------RLFAYSSW 332 ++ Y + G P + + + Sbjct: 130 SDKNNPYRDYYFWRDGKDNQPPNNYPSFFGGSAWQKDAKSGQYYLHYFARQQPDLNWDNP 189 Query: 333 EILRFLLSNIRWWLEEYRFDGFRFDGVTS---MLYHHHGVGQGFSGDYSEYFGLQVDEDA 389 ++ L + +R+WL++ G RFD V + + + + +Y + Sbjct: 190 KVREDLYAMLRFWLDK-GVSGMRFDTVATYSKIPGFPNLTPEQQKNFAEQYTMG---PNI 245 Query: 390 LTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYR---LAMAIPDKWIQL 446 Y+ N V + D T E P+ + FD R L MA I+L Sbjct: 246 HRYIQEMNRKVLSRY-DVATAGEIFG------VPLDRSSQFFDRRRHELNMAFMFDLIRL 298 Query: 447 LKE----FKDEDWNMGD----IVYTLTNRRYLEKCIAYAESHDQ----ALVGDKSLAFWL 494 ++ ++ + W++ I + ++HD + GD + Sbjct: 299 DRDSNERWRHKSWSLSQFRQIISKMDVTVGKYGWNTFFLDNHDNPRAVSHFGDDRPQWRE 358 Query: 495 MDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPE----WLD 550 A+ +++ TP I +G + LG Y NEF E W D Sbjct: 359 ASAKALATITLTQRATPFIYQGSE-----------LGMTNYPFRQLNEFDDIEVKGFWQD 407 Query: 551 FPRKGNNESYHYARRQFHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAAPQAYVSEKHEG 610 + + G + + LT D R F N D W YV E Sbjct: 408 YVQSGKVTATEFLD-NVRLTSRDNSRTPFQWN-DTLNAGFTRGKPWFHINPNYVEINAER 465 Query: 611 NK 612 + Sbjct: 466 EE 467 >5H05-A nrPDB Length = 640 Score = 136 bits (342), Expect = 3e-32, Method: Composition-based stats. Identities = 49/198 (24%), Positives = 73/198 (36%), Gaps = 47/198 (23%) Query: 196 SLRIYESHV----------------GISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMA 239 LRIY+ V G S H+G + + L I+ LG N I L Sbjct: 13 DLRIYQVMVESFVNGDDAIGHGTGYGTSHHKGDLQG----IIDSLDYIESLGMNAIWLTP 68 Query: 240 IMEH---AYYASF-------GYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVH 289 I + + GY +++FA R+GT E+ +ELV+ AH G+ V D V Sbjct: 69 IFDSIPVEGQDHWADRLDATGYFTSNYFAVDPRFGTMEQAKELVEKAHEKGLYVFFDGVF 128 Query: 290 SHASKNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEY 349 H N P G + ++ +Y E L F +W+EE Sbjct: 129 GHHKDNVVP---------------SPEGRLPVGENNPVSY--PESLAFYQEVATFWIEEL 171 Query: 350 RFDGFRFDGVTSMLYHHH 367 + DG+R D + Sbjct: 172 KIDGWRLDQAYQVPTEAW 189 >1CYG-A nrPDB Length = 680 Score = 135 bits (340), Expect = 6e-32, Method: Composition-based stats. Identities = 42/229 (18%), Positives = 76/229 (33%), Gaps = 42/229 (18%) Query: 205 GISSHEGKVASYKHFTCNVLP--RIKGLGYNCIQLM-AIME--------HAYYASFGYQI 253 G ++ N + + +G I + + + GY Sbjct: 39 GCTNLRKYCGGDWQGIINKINDGYLTDMGVTAIWISQPVENVFSVMNDASGSASYHGYWA 98 Query: 254 TSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNM----------- 302 F + +GT + Q LVD AH+ GI V++D +H S S + Sbjct: 99 RDFKKPNPFFGTLSDFQRLVDAAHAKGIKVIIDFAPNHTSPASETNPSYMENGRLYDNGT 158 Query: 303 ----FDGTDSCYFHSG--------PRGTH-DLWDSRLFAYSSWEILRFLLSNIRWWLEEY 349 + + YFH G + +L+D + + I R+L ++ W+ + Sbjct: 159 LLGGYTNDANMYFHHNGGTTFSSLEDGIYRNLFDLADLNHQNPVIDRYLKDAVKMWI-DM 217 Query: 350 RFDGFRFDGVTSMLY------HHHGVGQGFSGDYSEYFGLQVDEDALTY 392 DG R D V M + + E+F + + DA + Sbjct: 218 GIDGIRMDAVKHMPFGWQKSLMDEIDNYRPVFTFGEWFLSENEVDANNH 266 >4HOX-A nrPDB Length = 559 Score = 133 bits (335), Expect = 2e-31, Method: Composition-based stats. Identities = 80/496 (16%), Positives = 160/496 (32%), Gaps = 75/496 (15%) Query: 195 RSLRIYESHVGIS-SHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQI 253 + Y+ + G + L +K LG + I + + + GY I Sbjct: 8 KQAVFYQVYPRSFKDTNGDGIGDLNGIIENLDYLKKLGIDAIWINPHYDSPNTDN-GYDI 66 Query: 254 TSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCY--- 310 + YGT E+ L+ + +++D+V +H S A + G ++ Y Sbjct: 67 RDYRKIMKEYGTMEDFDRLISEMKKRNMRLMIDIVINHTSDQHAWFVQSKSGKNNPYRDY 126 Query: 311 --FHSGPRGTHDL----------WD----------------SRLFAYSSWEILRFLLSNI 342 + G G W+ + + ++ + L + Sbjct: 127 YFWRDGKDGHAPNNYPSFFGGSAWEKDDKSGQYYLHYFAKQQPDLNWDNPKVRQDLYDML 186 Query: 343 RWWLEEYRFDGFRFDGVTSM--LYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLV 400 R+WL++ G RFD V + + + + Q +++E + Y+ N V Sbjct: 187 RFWLDK-GVSGLRFDTVATYSKIPNFPDLSQQQLKNFAEEYT--KGPKIHDYVNEMNREV 243 Query: 401 HTLCPDSITIAEDVSGMPALCSPISQGGGGFDYR---LAMAIPDKWIQLLKE----FKDE 453 + D T E P+ + FD R L +A I+L ++ ++ + Sbjct: 244 LSHY-DIATAGEIFG------VPLDKSIKFFDRRRNELNIAFTFDLIRLDRDADERWRRK 296 Query: 454 DWNMGD----IVYTLTNRRYLEKCIAYAESHDQ---ALVGDKSLAFWLMD-AEMYTNMSV 505 DW + + + ++HD W A+ +++ Sbjct: 297 DWTLSQFRKIVDKVDQTAGEYGWNAFFLDNHDNPRAVSHFGDDRPQWREHAAKALATLTL 356 Query: 506 LTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGNNESYHYARR 565 TP I +G +L + +F E W D+ G ++ + + Sbjct: 357 TQRATPFIYQGSELGMTNY------PFKKIDDFDDVEV-KGFWQDYVETGKVKAEEFLQ- 408 Query: 566 QFHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAAPQAY-----VSEKHEGNKIIAFERAG 620 T D R F + ++ WL Y + + N + + R Sbjct: 409 NVRQTSRDNSRTPFQWDASKNA-GFTSGTPWLKINPNYKEINSADQINNPNSVFNYYRK- 466 Query: 621 LLFIFNFHPSKSYTDY 636 L+ I + P+ +Y Y Sbjct: 467 LINIRHDIPALTYGSY 482 >1V3M-A nrPDB Length = 686 Score = 132 bits (331), Expect = 7e-31, Method: Composition-based stats. Identities = 39/187 (20%), Positives = 69/187 (36%), Gaps = 37/187 (19%) Query: 214 ASYKHFTCNVLP--RIKGLGYNCIQLM-AIME---------HAYYASFGYQITSFFAASS 261 N + + G+G I + + A GY F + Sbjct: 51 GGDWQGIINKINDGYLTGMGITAIWISQPVENIYSVINYSGVNNTAYHGYWARDFKKTNP 110 Query: 262 RYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLN----------------MFDG 305 YGT ++ + L+DTAH+ I V++D +H S S+D + + Sbjct: 111 AYGTMQDFKNLIDTAHAHNIKVIIDFAPNHTSPASSDDPSFAENGRLYDNGNLLGGYTND 170 Query: 306 TDSCYFHSG-------PRGTH-DLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFD 357 T + + H G G + +L+D +++ + +L I+ WL + DG R D Sbjct: 171 TQNLFHHYGGTDFSTIENGIYKNLYDLADLNHNNSSVDVYLKDAIKMWL-DLGVDGIRVD 229 Query: 358 GVTSMLY 364 V M + Sbjct: 230 AVKHMPF 236 >4AIE-A nrPDB Length = 549 Score = 131 bits (330), Expect = 8e-31, Method: Composition-based stats. Identities = 73/465 (15%), Positives = 143/465 (30%), Gaps = 83/465 (17%) Query: 195 RSLRIYESH-VGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQI 253 ++ +Y+ + G + L ++ LG + I L + + + GY I Sbjct: 8 KNAVVYQVYPKSFQDSNGDGIGDLQGIISRLDYLEKLGIDAIWLSPVYQSPGVDN-GYDI 66 Query: 254 TSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDS----C 309 + + A +YGT ++ EL+ A I +++D+V +H S + G D+ Sbjct: 67 SDYEAIDPQYGTMADMDELISKAKEHHIKIVMDLVVNHTSDQHKWFVEAKKGKDNQYRDY 126 Query: 310 YFHSGPRGTHDLWDS---------------------------RLFAYSSWEILRFLLSNI 342 Y P H+ D + + E+ + + + + Sbjct: 127 YIWRDPVDEHEPNDLKSAFSGSAWKYDERSGQYYLHFFADQQPDLNWQNTELRQKIYNMM 186 Query: 343 RWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHT 402 +WL++ GFR D + + G + + YL N Sbjct: 187 NFWLDK-GIGGFRMDVIELI------------GKDPDKNIRENGPMLHPYLQEMNKATFG 233 Query: 403 LCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNMGDIVY 462 D +T+ E + P + S + L+M + L ++ E W++ + Sbjct: 234 KR-DVMTVGETWNATPKIAEEYSDP---DRHELSMVFQFENQSLDQQPGKEKWDLKPLDL 289 Query: 463 TLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRG---IQL 519 + ++ H ++ + N + + + +Q Sbjct: 290 GELKKVLVKWQTKIDFDH-------------AWNSLFWENHDIPRVISRWGNDQEYRVQC 336 Query: 520 HKMIRLITHGLGGEGYLNFMGNEFGHP-------------EWLDFP--RKGNNESYHYAR 564 KM +I H + G Y+ F G E G E ++ R Sbjct: 337 AKMFAIILHMMHGTPYI-FNGEEIGMTNCPVKNIDEVEDIESINMYNERLAEGYDEEELI 395 Query: 565 RQFHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAAPQAYVSEKHE 609 ++ D R N D E WL+ Y E Sbjct: 396 HAINVKGRDNARRPMQWN-DEKNAGFSEVDPWLSVNPNYKDINVE 439 >3DHU-A nrPDB Length = 449 Score = 131 bits (329), Expect = 1e-30, Method: Composition-based stats. Identities = 59/330 (17%), Positives = 110/330 (33%), Gaps = 29/330 (8%) Query: 195 RSLRIYESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFG---- 250 R+ IY V S G A L RIK LG + + L+ I G Sbjct: 11 RNEMIYSVFVRNYSEAGNFAG----VTADLQRIKDLGTDILWLLPINPIGEVNRKGTLGS 66 Query: 251 -YQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSC 309 Y I + + YGT + + L D AH +G+ V+LD+V++H S +S + Sbjct: 67 PYAIKDYRGINPEYGTLADFKALTDRAHELGMKVMLDIVYNHTSPDS-----VLATEHPE 121 Query: 310 YFHSGPRGTH-----DLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLY 364 +F+ G D D + Y E+ ++ + + +W ++ DG+R D + Sbjct: 122 WFYHDADGQLTNKVGDWSDVKDLDYGHHELWQYQIDTLLYW-SQF-VDGYRCDVAPLVPL 179 Query: 365 HHH-GVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSP 423 + + Y E L + ++ +T DS ++ + Sbjct: 180 DFWLEARKQVNAKYPETLWLAESAGSG-FIEELRSQGYTGLSDS-----ELYQAFDMTYD 233 Query: 424 ISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNMGDIVYTLTNRRYLEKCIAYAESHDQA 483 G F + L + +D + + + ++ S +A Sbjct: 234 YDVFG-DFKDYWQGRSTVERYVDLLQRQDATFPGNYVKMRFLENHDNARMMSLMHSKAEA 292 Query: 484 LVGDKSLAFWLMDAEMYTNMSVLTPFTPVI 513 + + +Y L P + Sbjct: 293 VNNLTWIFMQRGIPLIYNGQEFLAEHQPSL 322 >3GBE-A nrPDB Length = 558 Score = 131 bits (328), Expect = 1e-30, Method: Composition-based stats. Identities = 86/501 (17%), Positives = 163/501 (32%), Gaps = 77/501 (15%) Query: 191 PKKPRSLRIYESHVGIS-SHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASF 249 PK + Y+ + G + L +K LG + I + + + Sbjct: 3 PKWWKEAVFYQVYPRSFKDTNGDGIGDINGIIEKLDYLKALGIDAIWINPHYDSPNTDN- 61 Query: 250 GYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDS- 308 GY I + YGT E+ L+ + +++DVV +H S + + D+ Sbjct: 62 GYDIRDYRKIMKEYGTMEDFDRLISEMKKRNMRLMIDVVINHTSDQNEWFVKSKSSKDNP 121 Query: 309 ---CYFHSG------PRGTHDLWDS---------------------RLFAYSSWEILRFL 338 YF P + + + ++ + L Sbjct: 122 YRGYYFWKDAKEGQAPNNYPSFFGGSAWQKDEKTNQYYLHYFAKQQPDLNWDNPKVRQDL 181 Query: 339 LSNIRWWLEEYRFDGFRFDGVTS---MLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLML 395 + +R+WL++ G RFD V + + + Q +EY + Y+ Sbjct: 182 YAMLRFWLDK-GVSGLRFDTVATYSKIPDFPNLTQQQLKNFAAEYTKG---PNIHRYVNE 237 Query: 396 ANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYR---LAMAIPDKWIQLLKE--- 449 N V + D T E P+ Q FD R L +A I+L ++ Sbjct: 238 MNKEVLSHY-DIATAGEIFG------VPLDQSIKFFDRRRDELNIAFTFDLIRLDRDSDQ 290 Query: 450 -FKDEDWNMGDIVYTLTN----RRYLEKCIAYAESHDQ----ALVGDKSLAFWLMDAEMY 500 ++ +DW + + N + ++HD + GD + A+ Sbjct: 291 RWRRKDWKLSQFRQIIDNVDRTAGEYGWNAFFLDNHDNPRAVSHFGDDRPQWREPSAKAL 350 Query: 501 TNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGNNESY 560 +++ TP I +G +L + F E W D+ G ++ Sbjct: 351 ATLTLTQRATPFIYQGSELGMTNY------PFKAIDEFDDIEV-KGFWHDYVETGKVKAD 403 Query: 561 HYARRQFHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAAPQAY-----VSEKHEGNKIIA 615 + + LT D R F + ++ W Y VS+ + + + Sbjct: 404 EFLQ-NVRLTSRDNSRTPFQWDGSKNA-GFTSGKPWFKVNPNYQEINAVSQVTQPDSVFN 461 Query: 616 FERAGLLFIFNFHPSKSYTDY 636 + R L+ I + P+ +Y Y Sbjct: 462 YYRQ-LIKIRHDIPALTYGTY 481 >4GI8-A nrPDB Length = 557 Score = 131 bits (328), Expect = 1e-30, Method: Composition-based stats. Identities = 88/556 (15%), Positives = 153/556 (27%), Gaps = 98/556 (17%) Query: 190 RPKKP--RSLRIYESHVGIS-SHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYY 246 +P P +S Y+ + G L +KGLG + I + Sbjct: 1 KPGAPWWKSAVFYQVYPRSFKDTNGDGIGDFKGLTEKLDYLKGLGIDAIWINPHYASPNT 60 Query: 247 ASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGT 306 + GY I+ + YGT E+ L+ G+ +++DVV +H+S + Sbjct: 61 DN-GYDISDYREVMKEYGTMEDFDRLMAELKKRGMRLMVDVVINHSSDQHEWFKSSRASK 119 Query: 307 DSCY-----FHSGPRGTHDLWDSRLFAYSSWE--------------------------IL 335 D+ Y + G G F S+WE + Sbjct: 120 DNPYRDYYFWRDGKDGHEPNNYPSFFGGSAWEKDPVTGQYYLHYLGRQQPDLNWDTPKLR 179 Query: 336 RFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYF-----GLQVDEDAL 390 L + +R+WL++ G RFD V + GF E + Sbjct: 180 EELYAMLRFWLDK-GVSGMRFDTVA-----TYSKTPGFPDLTPEQMKNFAEAYTQGPNLH 233 Query: 391 TYLMLANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEF 450 YL + V D++T E G P P+ + +A + Sbjct: 234 RYLQEMHEKVFDHY-DAVTAGEIF-GAPLNQVPLFIDSRRKELDMAFTFDLIRYDRALDR 291 Query: 451 -KDEDWNMGDIVYTLTN----RRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSV 505 + D T+ + +HD + ++ Sbjct: 292 WHTIPRTLADFRQTIDKVDAIAGEYGWNTFFLGNHD--------------NPRAVSHFGD 337 Query: 506 LTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEW-----LDF--------- 551 P + + + L G F G+E G + DF Sbjct: 338 DRP--QWREASAKALATVTLTQRGTP----FIFQGDELGMTNYPFKTLQDFDDIEVKGFF 391 Query: 552 --PRKGNNESYHYARRQFHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAAPQAYVSEKHE 609 + + LT D R F + D WL Y Sbjct: 392 QDYVETGKATAEELLTNVALTSRDNARTPFQWD-DSANAGFTTGKPWLKVNPNYTEIN-- 448 Query: 610 GNKIIAFERAGLLFIFNFHPSKSYTDYRVGTALPGKFKIVLDSDAAEYGGHQRLDHSTDF 669 A E +++F+ + + G ++ + S+A Y + D T Sbjct: 449 ----AAREIGDPKSVYSFYRNLISIRHETPALSTGSYRDIDPSNADVYAYTRSQDGET-- 502 Query: 670 FSEAFEHNGRPYSLLV 685 + P S + Sbjct: 503 YLVVVNFKAEPRSFTL 518 >4CGT-A nrPDB Length = 678 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 42/208 (20%), Positives = 76/208 (36%), Gaps = 33/208 (15%) Query: 186 FKHSRPKKPRSLRIYESHVGISSHEGKVASYKHFTCNVLP--RIKGLGYNCIQLM-AIME 242 F P + Y++ S+ + N + LG + + + Sbjct: 25 FLDGNPSNNPTGAAYDA--TCSNLKLYCGGDWQGLINKINDNYFSDLGVTALWISQPVEN 82 Query: 243 ---------HAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHAS 293 A GY F + +GT + Q L+ TAH+ GI +++D +H S Sbjct: 83 IFATINYSGVTNTAYHGYWARDFKKTNPYFGTMADFQNLITTAHAKGIKIVIDFAPNHTS 142 Query: 294 KNSADGLNMFDG----------TDSCYFHSG-------PRGTH-DLWDSRLFAYSSWEIL 335 A+ ++D T+ + H+G G + +L+D F +++ I Sbjct: 143 PADAENGRLYDNGTLVGGYTNDTNGYFHHNGGSDFSSLENGIYKNLYDLADFNHNNATID 202 Query: 336 RFLLSNIRWWLEEYRFDGFRFDGVTSML 363 ++ I+ WL + DG R D V M Sbjct: 203 KYFKDAIKLWL-DMGVDGIRVDAVKHMP 229 >4J3X-A nrPDB Length = 905 Score = 127 bits (318), Expect = 2e-29, Method: Composition-based stats. Identities = 56/359 (15%), Positives = 116/359 (32%), Gaps = 76/359 (21%) Query: 76 FGVHRCADGGLYCKEWAPGAEGVFLTGDFNGWNPFSYPYKKLD--YGKWELYIPPKQNKS 133 G D + WAP A+GV + F+G + +L G W + P + Sbjct: 150 LGAVFSED-SVSLHLWAPTAQGVSVCF-FDGPAGPALETVQLKESNGVWSVTGPREWENR 207 Query: 134 VLVPHGSKLKVVITSKSGEILYRI---SPWAKYVVREGDNVNYDWIHWD---PEHSYEFK 187 +V + + + + P+A+ + G I+ + P E Sbjct: 208 YY-----LYEVDVYHPTKAQVLKCLAGDPYARSLSANGARTWLVDINNETLKPASWDELA 262 Query: 188 HSRPK--KPRSLRIYESHVGISSHE---------GKVASYKHFTCNVLPRIKGL---GYN 233 +PK + IYE H+ S G ++ + + ++ L G Sbjct: 263 DEKPKLDSFSDITIYELHIRDFSAHDGTVDSDSRGGFRAFAYQASAGMEHLRKLSDAGLT 322 Query: 234 CIQLMAIMEHAYYA-------------------------------------SFGYQITSF 256 + L+ A ++GY + Sbjct: 323 HVHLLPSFHFAGVDDIKSNWKFVDECELATFPPGSDMQQAAVVAIQEEDPYNWGYNPVLW 382 Query: 257 FAASSRYGTPEE-------LQELVDTAHSMGIIVLLDVVHSHASKNSADGLN-MFDGTDS 308 Y + + +++V + +G+ V++DVV++H + G++ + D Sbjct: 383 GVPKGSYASDPDGPSRIIEYRQMVQALNRIGLRVVMDVVYNHLDSSGPCGISSVLDKIVP 442 Query: 309 CYF--HSGPRGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYH 365 Y+ + A + + R ++ ++ W Y+ DGFRFD + ++ Sbjct: 443 GYYVRRDTNGQIENSAAMNNTASEHFMVDRLIVDDLLNWAVNYKVDGFRFDLMGHIMKR 501 >1LWJ-A nrPDB Length = 441 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 37/192 (19%), Positives = 63/192 (32%), Gaps = 33/192 (17%) Query: 200 YESHVGISSHEG-KVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFA 258 Y+ +V N + +K LG + + LM + + GY + F++ Sbjct: 4 YQIYVRSFRDGNLDGVGDFRGLKNAVSYLKELGIDFVWLMPVFSSISF--HGYDVVDFYS 61 Query: 259 ASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCY-------- 310 + YG+ E +E+++ H GI V+LD+ H G D Y Sbjct: 62 FKAEYGSEREFKEMIEAFHDSGIKVVLDLPIHHTGFLHTWFQKALKG-DPHYRDYYVWAN 120 Query: 311 ----------------FHSGPRGTHDLWDSRLF----AYSSWEILRFLLSNIRWWLEEYR 350 +H G F Y + ++ + + L + Sbjct: 121 KETDLDERREWDGEKIWHPLEDGRFYRGLFGPFSPDLNYDNPQVFDEMKRLVLHLL-DMG 179 Query: 351 FDGFRFDGVTSM 362 DGFRFD M Sbjct: 180 VDGFRFDAAKHM 191 >2ZIC-A nrPDB Length = 543 Score = 123 bits (309), Expect = 2e-28, Method: Composition-based stats. Identities = 65/446 (14%), Positives = 137/446 (30%), Gaps = 68/446 (15%) Query: 205 GISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYG 264 G + L ++ LG I L + + + GY I ++ A + +G Sbjct: 18 SFMDTNGDGIGDLKGITSKLDYLQKLGVMAIWLSPVYDSPMDDN-GYDIANYEAIADIFG 76 Query: 265 TPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSC-----YFHSGPRGTH 319 ++ L+ A GI +++D+V +H S A + + DS + P Sbjct: 77 NMADMDNLLTQAKMRGIKIIMDLVVNHTSDEHAWFIEAREHPDSSERDYYIWCDQPNDLE 136 Query: 320 DLWDS---------------------RLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDG 358 ++ + + + + + + +W+++ GFR D Sbjct: 137 SIFGGSAWQYDDKSDQYYLHFFSKKQPDLNWENANLRQKIYDMMNFWIDK-GIGGFRMDV 195 Query: 359 VTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMP 418 + + G + YL N D +T+ E P Sbjct: 196 IDMI------------GKIPAQHIVSNGPKLHAYLKEMNAASFGQH-DLLTVGETWGATP 242 Query: 419 ALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNMGDIVYTLTNRRYLEKCIAYAE 478 + S ++ L+M + I L + + W+ + + K E Sbjct: 243 EIAKQYSNP---VNHELSMVFQFEHIGLQHKPEAPKWDYVKELNVPALKTIFNKWQTELE 299 Query: 479 SHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGI---QLHKMIRLITHGLGGEGY 535 ++ + N + + + G + K + ++ H + G Y Sbjct: 300 ------------LGQGWNSLFWNNHDLPRVLSIWGNTGKYREKSAKALAILLHLMRGTPY 347 Query: 536 LNFMGNEFGHPEW--LDFPRKGNNESYHYARRQFHLTDDDLLRYKFLNNFDRDMNRLEER 593 + + G E G + D + ES +YA+ F + RD R + Sbjct: 348 I-YQGEEIGMTNYPFKDLNELDDIESLNYAKEAFTNGKSMETIMDSIRMIGRDNARTPMQ 406 Query: 594 Y------GWLAAPQAYVSEKHEGNKI 613 + G+ A + ++ I Sbjct: 407 WDASQNAGFSTADKTWLPVNPNYKDI 432 >2AAA-A nrPDB Length = 484 Score = 123 bits (308), Expect = 3e-28, Method: Composition-based stats. Identities = 40/172 (23%), Positives = 61/172 (35%), Gaps = 28/172 (16%) Query: 214 ASYKHFTCNVLPRIKGLGYNCIQLMAIMEH------AYYASFGYQITSFFAASSRYGTPE 267 + L I+G+G+ I + I E A GY + +S +GT + Sbjct: 39 GGSWQGIIDHLDYIEGMGFTAIWISPITEQLPQDTADGEAYHGYWQQKIYDVNSNFGTAD 98 Query: 268 ELQELVDTAHSMGIIVLLDVVHSHASKNSADG---LNMFDGTD-SCYFHSGPRGTHDLWD 323 L+ L D H+ G+ +++DVV H ++FD D S YFH P WD Sbjct: 99 NLKSLSDALHARGMYLMVDVVPDHMGYAGNGNDVDYSVFDPFDSSSYFH--PYCLITDWD 156 Query: 324 SRLFAYSSWE----------------ILRFLLSNIRWWLEEYRFDGFRFDGV 359 + WE + + + Y DG R D V Sbjct: 157 NLTMVEDCWEGDTIVSLPDLDTTETAVRTIWYDWVADLVSNYSVDGLRIDSV 208 >2Z1K-A nrPDB Length = 475 Score = 122 bits (307), Expect = 4e-28, Method: Composition-based stats. Identities = 73/468 (15%), Positives = 140/468 (29%), Gaps = 79/468 (16%) Query: 208 SHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPE 267 + G LP + LG I L + A A+ Y +F G E Sbjct: 40 TLRGFKGGTLWGVAEKLPYLLDLGVEAIYLNPVF--ASTANHRYHTVDYFQVDPILGGNE 97 Query: 268 ELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYF---------------- 311 L+ L++ AH+ G+ V+LD V +H + ++ + + + Sbjct: 98 ALRHLLEVAHAHGVRVILDGVFNHTGRGFFAFQHLMENGEQSPYRDWYHVKGFPLKAYTA 157 Query: 312 HSGPRGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSML---YHHHG 368 H + + + +LL+ W+ + DG+R D + + Sbjct: 158 HPNYEAWWGNPELPKLKVETPAVREYLLAVAEHWIR-FGVDGWRLDVPNEIPDPTFWREF 216 Query: 369 VGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPISQGG 428 + + Y ++ E+A +L P + + V G +Q G Sbjct: 217 RQRVKGANPEAYIVGEIWEEADFWLQGDMFDAVMNYPLARAVLGFVGGEALDRDLAAQTG 276 Query: 429 GG-FDYRLAMAIPDKWIQLLKEFKDEDWNMGDIVYTLTNRRYLEKCIAYAESHDQALVGD 487 G + A+A + L ++ + + SHD Sbjct: 277 LGRIEPLQALAFSHRLEDLFGRYR---------------PEVVRAQMNLLTSHDTP---- 317 Query: 488 KSLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPE 547 ++ ++ ++ + L G + + G E G Sbjct: 318 --------------------RLLSLMRGSVERARLALALLFLLPGNPTV-YYGEEVGMAG 356 Query: 548 WLDFPRKGNNESYHYARRQFHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAAPQAYVSEK 607 D P + AR Q K L + + RL + + L Sbjct: 357 GKD-PENRGGMVWEEARWQ-----------KDLRETVKRLARLRKEHPALRTAPYLRIYA 404 Query: 608 HEGNKIIAFERAGLLFIFNFHPSKSYTDYRV-GT-ALPGKFKIVLDSD 653 +G+ +AF R L + N P D+ + G G+ +L + Sbjct: 405 QDGH--LAFARGPYLAVVNASPHPFRQDFPLHGVFPRGGRAVDLLSGE 450 >1EO7-A nrPDB Length = 686 Score = 121 bits (304), Expect = 9e-28, Method: Composition-based stats. Identities = 37/187 (19%), Positives = 66/187 (35%), Gaps = 37/187 (19%) Query: 214 ASYKHFTCNVLP--RIKGLGYNCIQLM-AIME---------HAYYASFGYQITSFFAASS 261 N + + G+G I + + A GY F + Sbjct: 51 GGDWQGIINKINDGYLTGMGVTAIWISQPVENIYSIINYSGVNNTAYHGYWARDFKKTNP 110 Query: 262 RYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLN----------------MFDG 305 YGT + Q L+ AH+ I V++D +H S S+D + + Sbjct: 111 AYGTIADFQNLIAAAHAKNIKVIIDFAPNHTSPASSDQPSFAENGRLYDNGTLLGGYTND 170 Query: 306 TDSCYFHSG-------PRGTH-DLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFD 357 T + + H+G G + +L+D +++ + +L I+ WL + DG R Sbjct: 171 TQNLFHHNGGTDFSTTENGIYKNLYDLADLNHNNSTVDVYLKDAIKMWL-DLGIDGIRMA 229 Query: 358 GVTSMLY 364 V M + Sbjct: 230 AVKHMPF 236 >4JCM-A nrPDB Length = 702 Score = 119 bits (299), Expect = 3e-27, Method: Composition-based stats. Identities = 36/204 (17%), Positives = 69/204 (33%), Gaps = 28/204 (13%) Query: 205 GISSHEGKVASYKHFTCNVLP--RIKGLGYNCIQLMA-------IMEHAYYASFGYQITS 255 G S + + + +G + + + + + GY Sbjct: 70 GCSDLTKYCGGDWQGIIDEIESGYLPDMGITALWISPPVENVFDLHPEGFSSYHGYWARD 129 Query: 256 FFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGT--------- 306 F + +G ++ L++TAH+ I V++D V +H S + ++D Sbjct: 130 FKKTNPFFGDFDDFSRLIETAHAHDIKVVIDFVPNHTSPVDIEDGALYDNGTLLGHYSTD 189 Query: 307 DSCYFHSGPRG---------THDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFD 357 + YF++ +L+D I ++L +I+ WL + DG R D Sbjct: 190 ANNYFYNYGGSDFSDYENSIYRNLYDLASLNQQHSFIDKYLKESIQLWL-DTGIDGIRVD 248 Query: 358 GVTSMLYHHHGVGQGFSGDYSEYF 381 V M DY+ F Sbjct: 249 AVAHMPLGWQKAFISSVYDYNPVF 272 >3AXH-A nrPDB Length = 589 Score = 119 bits (299), Expect = 3e-27, Method: Composition-based stats. Identities = 74/516 (14%), Positives = 145/516 (28%), Gaps = 103/516 (19%) Query: 188 HSRPKKPRSLRIYESH-VGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYY 246 + PK + Y+ + + L IK LG + I + + Sbjct: 9 ETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQD 68 Query: 247 ASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGT 306 GY I ++ YGT E+ L++ H +G+ + D+V +H S Sbjct: 69 D-MGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSK 127 Query: 307 DSC----YFHSGPRGT--------HDLWDS-------------------------RLFAY 329 + +F P+G + W S + Sbjct: 128 TNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNW 187 Query: 330 SSWEILRFLLSNIR-WWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQ---- 384 + + + + + +WL ++ DGFR D V S+ G+ D + + Sbjct: 188 ENEDCRKAIYESAVGYWL-DHGVDGFRID-VGSLYSKVVGLPDAPVVDKNSTWQSSDPYT 245 Query: 385 -VDEDALTYLMLANHLVHTLCPD--------SITIAEDVSGMPALCSPISQGGGGFDY-R 434 + N + D ++ A D + + + F++ Sbjct: 246 LNGPRIHEFHQEMNQFIRNRVKDGREIMTVGAMQHASDETKRLYTSASRHELSELFNFSH 305 Query: 435 LAMAIPDKWIQLLKEFKDEDWNMGDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWL 494 + + L F+ +DW + Y E+HDQ Sbjct: 306 TDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQ------------ 353 Query: 495 MDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRK 554 T +P + K++ ++ L G Y+ + G E G + ++P + Sbjct: 354 --PRSITRFGDDSP-----KNRVISGKLLSVLLSALTGTLYV-YQGQELGQINFKNWPVE 405 Query: 555 -------------------GNNESYHYARRQFHLTDDDLLRYKFLNNFDRDMNRL--EER 593 N+E L D R + + Sbjct: 406 KYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSA 465 Query: 594 YGWLAAPQAY------VSEKHEGNKIIAFERAGLLF 623 W ++ E + N ++ F + L F Sbjct: 466 KPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKF 501 >4AEE-A nrPDB Length = 696 Score = 119 bits (298), Expect = 4e-27, Method: Composition-based stats. Identities = 53/376 (14%), Positives = 103/376 (27%), Gaps = 102/376 (27%) Query: 211 GKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQ 270 G + ++ LG I L I Y Y + + GT E+ + Sbjct: 258 GYYGGDLAGIMKHIDHLEDLGVETIYLTPIFSSTSYHR--YDTIDYKSIDKYLGTMEDFE 315 Query: 271 ELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSC--------------------- 309 +LV HS I ++LD+ H + + + ++ Sbjct: 316 KLVQVLHSRKIKIVLDITMHHTNPCNELFVKALREGENSPYWEMFSFLSPPPKEIVELML 375 Query: 310 -----------------YFHSGP---RGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEY 349 YF + ++W F + + + + + ++W+++ Sbjct: 376 KYIDGEECRSRELYKLDYFRNNKPFYEAFFNIWLMAKFNHDNPRTVDYFIDITKFWIDK- 434 Query: 350 RFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSIT 409 DGFR D + Y +++ + PD + Sbjct: 435 GIDGFRIDVAMGIHY--------------------------SWMKQYYEYIKNTYPDFLV 468 Query: 410 IAEDVSGMPALCSPISQGGGGFDYRLA-MAIPDKWIQLLKEFKDEDWNMGDIVYTLTNRR 468 + E P + + R A + + L EF N VY Sbjct: 469 LGELAEN-PRIYMDYFDSAMNYYLRKAILELLIYKRIDLNEFISRINN----VYAYIPHY 523 Query: 469 YLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITH 528 SHD P + + +L K++ ++ Sbjct: 524 KALSLYNMLGSHD-------------------------VPRIKSMVQNNKLLKLMYVLIF 558 Query: 529 GLGGEGYLNFMGNEFG 544 L G + + G+E G Sbjct: 559 ALPGSPVI-YYGDEIG 573 >6A0L-A nrPDB Length = 471 Score = 119 bits (298), Expect = 4e-27, Method: Composition-based stats. Identities = 32/173 (18%), Positives = 58/173 (33%), Gaps = 18/173 (10%) Query: 205 GISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYG 264 + + + L I LG N + L I E + Y +F+ R G Sbjct: 58 STPTPDNFFGGDLQGIIDHLDHIVALGANALYLTPIFEA--DTNHRYDAKDYFSIDHRLG 115 Query: 265 TPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYF------------- 311 T E L+ + GI ++LD V +H ++ + + Sbjct: 116 TLETFHALMAECRARGIRIVLDAVLNHCGDGHWAFADVVENEADSAYVNWFSVEGFPVTA 175 Query: 312 HSGP--RGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSM 362 H P R + + + E+ L R+W+++ DG+R D + Sbjct: 176 HPTPNYRTCSGCYYLPKWNAYNPEVRHHHLDVARYWIDQ-GIDGWRLDVPYFI 227 >1QHO-A nrPDB Length = 686 Score = 118 bits (296), Expect = 6e-27, Method: Composition-based stats. Identities = 39/190 (20%), Positives = 56/190 (29%), Gaps = 43/190 (22%) Query: 212 KVASYKHFTCNVLPRIKGLGYNCIQLMAIME-------HAYYASFGYQITSFFAASSRYG 264 LP +K LG I L +++ GY F +G Sbjct: 46 YWGGDLEGVRQKLPYLKQLGVTTIWLSPVLDNLDTLAGTDNTGYHGYWTRDFKQIEEHFG 105 Query: 265 TPEELQELVDTAHSMGIIVLLDVVHSHASK----------------NSADGLNMFDGTDS 308 LV+ AH GI V++D V +H++ N N FD Sbjct: 106 NWTTFDTLVNDAHQNGIKVIVDFVPNHSTPFKANDSTFAEGGALYNNGTYMGNYFDDATK 165 Query: 309 CYFHSGPRGTHDLWDSR-----------------LFAYSSWEILRFLLSNIRWWLEEYRF 351 YFH G WD R + + I ++L + + Sbjct: 166 GYFHHN--GDISNWDDRYEAQWKNFTDPAGFSLADLSQENGTIAQYLTDAAVQLVA-HGA 222 Query: 352 DGFRFDGVTS 361 DG R D V Sbjct: 223 DGLRIDAVKH 232 >1A47-A nrPDB Length = 683 Score = 117 bits (293), Expect = 2e-26, Method: Composition-based stats. Identities = 39/195 (20%), Positives = 67/195 (34%), Gaps = 38/195 (19%) Query: 207 SSHEGKVASYKHFTCNVLP--RIKGLGYNCIQLM-AIME----------HAYYASFGYQI 253 +S + N + + G+G I + + + GY Sbjct: 44 TSLKKYFGGDWQGIINKINDGYLTGMGVTAIWISQPVENIYAVLPDSTFGGSTSYHGYWA 103 Query: 254 TSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNM----------- 302 F + +G+ + Q L++TAH+ I V++D +H S S Sbjct: 104 RDFKRTNPYFGSFTDFQNLINTAHAHNIKVIIDFAPNHTSPASETDPTYAENGRLYDNGT 163 Query: 303 ----FDGTDSCYFH--------SGPRGTH-DLWDSRLFAYSSWEILRFLLSNIRWWLEEY 349 + + YFH S G + +L+D + I +L S I+ WL + Sbjct: 164 LLGGYTNDTNGYFHHYGGTDFSSYEDGIYRNLFDLADLNQQNSTIDSYLKSAIKVWL-DM 222 Query: 350 RFDGFRFDGVTSMLY 364 DG R D V M + Sbjct: 223 GIDGIRLDAVKHMPF 237 >2TAA-A nrPDB Length = 478 Score = 115 bits (288), Expect = 5e-26, Method: Composition-based stats. Identities = 34/175 (19%), Positives = 61/175 (34%), Gaps = 28/175 (16%) Query: 214 ASYKHFTCNVLPRIKGLGYNCIQLMAIMEH------AYYASFGYQITSFFAASSRYGTPE 267 + L I+G+G+ I + + A GY T ++ + YGT + Sbjct: 39 GGTWQGIIDKLDYIQGMGFTAIWITPVTAQLPQDCAYGDAYTGYWQTDIYSLNENYGTAD 98 Query: 268 ELQELVDTAHSMGIIVLLDVVHSHASKNSAD---GLNMFDGTDS-CYFHSGPRGTHDLWD 323 +L+ L H G+ +++DVV +H + A ++F S YFH P ++ Sbjct: 99 DLKALSSALHERGMYLMVDVVANHMGYDGAGSSVDYSVFKPFSSQDYFH--PFCFIQNYE 156 Query: 324 SRLFAYSSW----------------EILRFLLSNIRWWLEEYRFDGFRFDGVTSM 362 + W + + + Y DG R D V + Sbjct: 157 DQTQVEDCWLGDNTVSLPDLDTTKDVVKNEWYDWVGSLVSNYSIDGLRIDTVKHV 211 >6AIJ-A nrPDB Length = 708 Score = 114 bits (286), Expect = 1e-25, Method: Composition-based stats. Identities = 35/189 (18%), Positives = 63/189 (33%), Gaps = 37/189 (19%) Query: 212 KVASYKHFTCNVLP--RIKGLGYNCIQLM-AIME---------HAYYASFGYQITSFFAA 259 + + + G+G + + + + GY F Sbjct: 70 YFGGDWQGIIDKINDGYLTGMGVTALWISQPVENITSVIKYSGVNNTSYHGYWARDFKQT 129 Query: 260 SSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGL----------------NMF 303 + +G + Q L+DTAH+ I V++D +H S D Sbjct: 130 NDAFGDFADFQNLIDTAHAHNIKVVIDFAPNHTSPADRDNPGFAENGALYDNGSLLGAYS 189 Query: 304 DGTDSCYFHSG-------PRGTH-DLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFR 355 + T + H+G G + +L+D +++ + + S I WL DG R Sbjct: 190 NDTAGLFHHNGGTDFSTIEDGIYKNLYDLADINHNNNAMDAYFKSAIDLWLG-MGVDGIR 248 Query: 356 FDGVTSMLY 364 FD V M + Sbjct: 249 FDAVKHMPF 257 >3VM7-A nrPDB Length = 492 Score = 108 bits (270), Expect = 7e-24, Method: Composition-based stats. Identities = 34/171 (19%), Positives = 64/171 (37%), Gaps = 22/171 (12%) Query: 214 ASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYA-----SFGYQITSFFAASSRYGTPEE 268 + L I+G+G++ + + I + GY T +A + +GT E+ Sbjct: 60 GGNYRGLISQLDYIQGMGFDSVWISPITKQFEDDWNGAPYHGYWQTDLYALNEHFGTEED 119 Query: 269 LQELVDTAHSMGIIVLLDVVHSHAS-KNSADGLNM--FDGTDSC-YFHSGPRGTHDLWDS 324 L+ L D H+ G+ +++DVV +H A ++ F+ +S Y+H +D S Sbjct: 120 LRALADELHARGMFLMVDVVINHNGWPGDAASIDYSQFNPFNSSDYYHPPCEINYDDQTS 179 Query: 325 -------------RLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSM 362 + + I + +Y DG R D + Sbjct: 180 VEQCWLYTGANALPDLKTEDPHVSQVHNDWIADLVSKYSIDGLRIDTTKHV 230 >4AEF-A nrPDB Length = 645 Score = 106 bits (265), Expect = 3e-23, Method: Composition-based stats. Identities = 40/226 (17%), Positives = 69/226 (30%), Gaps = 41/226 (18%) Query: 205 GISSHEGK-VASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRY 263 GI+ + K + + LG N I L I Y GY I +F + R Sbjct: 225 GIAYPKDKYWGGDLIGIKEKIDHLVNLGINAIYLTPIFSSLTY--HGYDIVDYFHVARRL 282 Query: 264 GTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSC-------------- 309 G +L+ I V+LD V H S ++ ++ Sbjct: 283 GGDRAFVDLLSELKRFDIKVILDGVFHHTSFFHPYFQDVVRKGENSSFKNFYRIIKFPVV 342 Query: 310 -----------------YFHSGPRGTHD-----LWDSRLFAYSSWEILRFLLSNIRWWLE 347 Y G + +W + + ++ F+ + I +W Sbjct: 343 SKEFLQILHSKSSWEEKYKKIKSLGWNYESFFSVWIMPRLNHDNPKVREFIKNVILFWTN 402 Query: 348 EYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYL 393 + DGFR D + + +Y +V +DA +L Sbjct: 403 K-GVDGFRMDVAHGVPPEVW-KEVREALPKEKYLIGEVMDDARLWL 446 >5BN7-A nrPDB Length = 616 Score = 106 bits (264), Expect = 4e-23, Method: Composition-based stats. Identities = 60/406 (14%), Positives = 112/406 (27%), Gaps = 69/406 (16%) Query: 158 SPWAKYVVREGDNVNYDWIHWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYK 217 +A+ + RE + + + H + P ++ Sbjct: 133 DRFARSLPREAEQDHVYYHHAAGQEIILRDWDEPVTAQA-----------GGSTFYGGDL 181 Query: 218 HFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAH 277 LP +K LG + L + + + Y + ++G L L Sbjct: 182 DGISEKLPYLKKLGVTALYLNPVFKAP--SVHKYDTEDYRHVDPQFGGDGALLRLRHNTQ 239 Query: 278 SMGIIVLLDVVHSHASKNSADGLNMFDGTDS----------CYFHSGPRGTHDLW----D 323 +G+ ++LD V +H+ + A GT ++ GT W Sbjct: 240 QLGMRLVLDGVFNHSGDSHAWFDRHNRGTGGACHNPESPWRDWYSFSDDGTALDWLGYAS 299 Query: 324 SRLFAYSSWEILRFLL----SNIRWWLEE-YRFDGFRFDGVTSMLYHHHGVGQGFSGDYS 378 Y S ++ + S +R WL+ + DG+R D V ML Sbjct: 300 LPKLDYQSESLVNEIYRGEDSIVRHWLKAPWNMDGWRLDVV-HMLG-------------- 344 Query: 379 EYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMA 438 E G + + + + A P++ + E Q D + Sbjct: 345 EAGGARNNMQHVAGITEA---AKETQPEAYIVGEHF----GDARQWLQADV-EDAAMNYR 396 Query: 439 IPDKWIQLLKEFKDEDWNMGDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAE 498 + D ++ I SH Q L L Sbjct: 397 GFTFPLWGFLANTDISYDPQQI--DAQTCMAWMDNYRAGLSHQQQLRMFNQL-------- 446 Query: 499 MYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFG 544 + F ++ R I + + G + + G+E G Sbjct: 447 ---DSHDTARFKTLLGRDIARLPLAVVWLFTWPGVPCI-YYGDEVG 488 >3UEQ-A nrPDB Length = 632 Score = 105 bits (261), Expect = 9e-23, Method: Composition-based stats. Identities = 71/495 (14%), Positives = 138/495 (27%), Gaps = 91/495 (18%) Query: 213 VASYKHFTCNVLPRIKGLGYNCIQLMAIMEHA-YYASFGYQITSFFAASSRYGTPEELQE 271 A + +P + LG + LM + + + GY ++S+ + GT +L+E Sbjct: 112 FAGDLKGLKDKIPYFQELGLTYLHLMPLFKCPEGKSDGGYAVSSYRDVNPALGTIGDLRE 171 Query: 272 LVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDG---TDSCYFHSGPRGTHDLWD----- 323 ++ H GI ++D + +H S G D+ Y+ R D +D Sbjct: 172 VIAALHEAGISAVVDFIFNHTSNEHEWAQRCAAGDPLFDNFYYIFPDRRMPDQYDRTLRE 231 Query: 324 --------------------------SRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFD 357 YS+ + R + + + L D R D Sbjct: 232 IFPDQHPGGFSQLEDGRWVWTTFNSFQWDLNYSNPWVFRAMAGEMLF-LANLGVDILRMD 290 Query: 358 GVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCP------DSITIA 411 V + + A + N ++ P ++I Sbjct: 291 AVAFI-------------WKQMGTSCENLPQAHALIRAFNAVMRIAAPAVFFKSEAIVHP 337 Query: 412 EDVSGMPA--------------------LCSPISQGGGGFDYRLAMAIPDKWIQLLKEFK 451 + V ++ YR + W+ ++ Sbjct: 338 DQVVQYIGQDECQIGYNPLQMALLWNTLATREVNLLHQALTYRHNLPEHTAWVNYVRSHD 397 Query: 452 DEDWNMGDI------VYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSV 505 D W D + +R++L + A D + + Sbjct: 398 DIGWTFADEDAAYLGISGYDHRQFLNRFFVNRFDGSFARGVPFQYNPSTGDCRVSGTAAA 457 Query: 506 LTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPR---KGNNESYHY 562 L + K++ I GG L ++G+E G D+ + K ++ + + Sbjct: 458 LVGLAQDDPHAVDRIKLLYSIALSTGGLP-LIYLGDEVGTLNDDDWSQDSNKSDDSRWAH 516 Query: 563 ARR----QFHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAAPQAYVSEKHEGNKIIAFER 618 R + +D + R M + + V+ II + R Sbjct: 517 RPRYNEALYAQRNDPSTAAGQIYQDLRHMIAVRQSNPRFDGG-RLVTFNTNNKHIIGYIR 575 Query: 619 AGLLFIF-NFHPSKS 632 L F NF Sbjct: 576 NNALLAFGNFSEYPQ 590 >3K8L-A nrPDB Length = 669 Score = 103 bits (257), Expect = 2e-22, Method: Composition-based stats. Identities = 24/106 (22%), Positives = 40/106 (37%), Gaps = 2/106 (1%) Query: 205 GISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYG 264 + +G + L + LG + L I H + GY +T + + + G Sbjct: 47 SFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPI--HPCMSYHGYDVTDYTKVNPQLG 104 Query: 265 TPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCY 310 T + LV AH+ GI + LD V +H ++S Y Sbjct: 105 TESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPY 150 Score = 40.9 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 31/146 (21%), Positives = 44/146 (30%), Gaps = 23/146 (15%) Query: 302 MFDGTDSCYFHS---GPRGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDG 358 MFD YFHS + A S + + + W+ DG R D Sbjct: 309 MFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAY-QAIADAAKGWIAR-GVDGLRLDA 366 Query: 359 VTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMP 418 V + + + + + F ED Y H D I E +S Sbjct: 367 VKHIYH-------SETSEENPRFLKMFYEDMNAYYKQKGHT-----DDFYMIGEVLSEYD 414 Query: 419 ALCSPISQG-----GGGFDYRLAMAI 439 + P +G F YRL I Sbjct: 415 KVA-PYYKGLPALFEFSFWYRLEWGI 439 >3EDF-A nrPDB Length = 601 Score = 99.5 bits (246), Expect = 4e-21, Method: Composition-based stats. Identities = 36/163 (22%), Positives = 57/163 (34%), Gaps = 24/163 (14%) Query: 220 TCNVLPRIKGLGYNCIQLMAI--MEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAH 277 T + L I GLG+ + + + A Y+ GY T + RYG+ E+ L A Sbjct: 150 TIDHLDYIAGLGFTQLWPTPLVENDAAAYSYHGYAATDHYRIDPRYGSNEDFVRLSTEAR 209 Query: 278 SMGIIVLLDVVHSHASKNS--------ADGLNMFDGTDSCYFH-----------SGPRGT 318 G+ ++ DVV SH K+ D +N H + Sbjct: 210 KRGMGLIQDVVLSHIGKHHWWMKDLPTPDWINYGGKFVPTQHHRVAVQDPYAAQADSENF 269 Query: 319 HDLW---DSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDG 358 W ++ + +L+ N WW+E G R D Sbjct: 270 TKGWFVEGMPDLNQTNPLVANYLIQNNIWWIEYAGLSGLRIDT 312 >3UER-A nrPDB Length = 655 Score = 97.2 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 46/291 (15%), Positives = 82/291 (28%), Gaps = 55/291 (18%) Query: 162 KYVVREGDNVNYDWIHWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYKHFTC 221 + + V H P +R +P L+ E VG ++ + A Sbjct: 56 RALPGRLLEVMLHAYHARPAELRRLDEARLLRPDWLQRPEM-VGYVAYTDRFAGTLKGVE 114 Query: 222 NVLPRIKGLGYNCIQLMAIMEH-AYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMG 280 L ++GLG + LM ++ GY + + A GT ++L L G Sbjct: 115 ERLDYLEGLGVKYLHLMPLLRPREGENDGGYAVQDYRAVRPDLGTMDDLSALARALRGRG 174 Query: 281 IIVLLDVVHSHASKNSADGLNMF--DGTDSCYFHSGPRGT-------------------H 319 I ++LD+V +H ++ A D YFH P + Sbjct: 175 ISLVLDLVLNHVAREHAWAQKARAGDPKYRAYFHLFPDRRGPDAFEATLPEIFPDFAPGN 234 Query: 320 DLWDS------------------RLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTS 361 WD +++ ++ + I + L + FR D + Sbjct: 235 FSWDEEIGEGEGGWVWTTFNSYQWDLNWANPDVFLEFVDIILY-LANRGVEVFRLDAIAF 293 Query: 362 MLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAE 412 + Q + + P AE Sbjct: 294 IWKRLGTD-------------CQNQPEVHHLTRALRAAARIVAPAVAFKAE 331 >2WPG-A nrPDB Length = 637 Score = 91.4 bits (225), Expect = 1e-18, Method: Composition-based stats. Identities = 54/367 (14%), Positives = 100/367 (27%), Gaps = 80/367 (21%) Query: 174 DWIHWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVA---------------SYKH 218 D++ W P+ +P +LR H+ S G Sbjct: 52 DYVTWLPQWLSALGVVAQARPAALR----HLDDSRAPGWFGQQDMLGYSAYVDRFAGTLR 107 Query: 219 FTCNVLPRIKGLGYNCIQLMAIMEH-AYYASFGYQITSFFAASSRYGTPEELQELVDTAH 277 +P ++ LG + L+ + A G+ ++ + G+ ++L L Sbjct: 108 GVAERVPYLQELGVRYLHLLPFLRARAGDNDGGFAVSDYGQVEPALGSNDDLVALTARLR 167 Query: 278 SMGIIVLLDVVHSHASKNSADGLNMFDGTD---SCYFHSGPRGTHDLWDS---------- 324 + I + D V +H + + A G Y H R D +D+ Sbjct: 168 AANISLCADFVLNHTADDHAWAQAARAGDTRYLDYYHHFADRNAPDQYDTTLVQVFPQTA 227 Query: 325 ----------------------RLFAYSSWEIL-RFLLSNIRWWLEEYRFDGFRFDGVTS 361 +S+ + L+ + L + FR D Sbjct: 228 PGNFTWVDETRQWMWTTFYPYQWDLNWSNPAVFGEMALAMLE--LANLGVEAFRLDSTAY 285 Query: 362 MLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPALC 421 + +A T L+ + + P + AE + M L Sbjct: 286 L-------------WKRPGTNCMNQPEAHTILVALRAVADIVAPSVVMKAEAIVPMAEL- 331 Query: 422 SPISQGGG---GFDYRLAMAIPDKWIQLLKEFKDEDWNMGDIVYTLTNRRYLEKC--IAY 476 P G G G + LA + D++ + C ++Y Sbjct: 332 -PPYFGSGVQRGHECHLAYHSTLMAAGWSALALQRGDILQDVI--AHSPPLPPNCAWLSY 388 Query: 477 AESHDQA 483 HD Sbjct: 389 VRCHDDI 395 >3CZE-A nrPDB Length = 644 Score = 90.6 bits (223), Expect = 2e-18, Method: Composition-based stats. Identities = 60/368 (16%), Positives = 114/368 (30%), Gaps = 78/368 (21%) Query: 172 NYDWIHWDPEHSYEFKHSRPKKPRSLRIYES----------H-VGISSHEGKVASYKHFT 220 D+ W + E ++P++L+ +S H +G S++ + A Sbjct: 49 RADYASWLAQWLGEVGDIARQRPQALQTLDSTRHAGWFGQPHMLGYSAYADRFAGTLQGV 108 Query: 221 CNVLPRIKGLGYNCIQLMAIMEH-AYYASFGYQITSFFAASSRYGTPEELQELVDTAHSM 279 +P ++ LG + L+ + A G+ ++ + G+ ++L L Sbjct: 109 AERVPYLQELGVRYLHLLPFLRARAGDNDGGFAVSDYGQVEPSLGSNDDLVALTSRLREA 168 Query: 280 GIIVLLDVVHSHASKNSADGLNMFDGTD---SCYFHSGPRGTHDLWD---SRLFAYSSWE 333 GI + D V +H + + A G Y H R D ++ ++F +++ Sbjct: 169 GISLCADFVLNHTADDHAWAQAARAGDARYLDYYHHFADRTVPDRYEATLGQVFPHTAPG 228 Query: 334 ILRFLLSNIRW-W---------------------------LEEYRFDGFRFDGVTSMLYH 365 ++ +W W L + FR D + Sbjct: 229 NFTWVDDTAQWMWTTFYPYQWDLNWSNPAVFGDMALAMLRLANLGVEAFRLDSTAYLWKR 288 Query: 366 HHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPIS 425 +A T L+ + + P + AE + M L P Sbjct: 289 IGTD-------------CMNQSEAHTLLVALRAVTDIVAPAVVMKAEAIVPMTQL--PPY 333 Query: 426 QGGG---GFDYRLAMAIPDK---WIQLLKEFKDEDWNMGDIVYT--LTNRRYLEKC--IA 475 G G G + LA W L + GDI++ + C ++ Sbjct: 334 FGSGVDEGHECHLAYHSTLMAAGWSALALQR-------GDILHNVIAHSPPLPRHCAWLS 386 Query: 476 YAESHDQA 483 Y HD Sbjct: 387 YVRCHDDI 394 >5Z0U-A nrPDB Length = 626 Score = 87.9 bits (216), Expect = 1e-17, Method: Composition-based stats. Identities = 29/186 (15%), Positives = 54/186 (29%), Gaps = 32/186 (17%) Query: 212 KVASYKHFTCNVLPRIKG-LGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQ 270 L IK LG N + L I + + Y + A +G LQ Sbjct: 185 FFGGDLAGIDQKLGYIKKTLGANILYLNPIFKAP--TNHKYDTQDYMAVDPAFGDNSTLQ 242 Query: 271 ELVDTAHS-----MGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHDLW--- 322 L++ HS G ++LD V +H + + + + S ++ + Sbjct: 243 TLINDIHSTANGPKG-YLILDGVFNHTGDSHPWFDKYNNFSSQGAYESQSSPWYNYYTFY 301 Query: 323 -------------DSRLFAYSS--WEILRFLLSNIR-----WWLEEYRFDGFRFDGVTSM 362 Y + + + +N + Y DG+R D + Sbjct: 302 TWPDSYASFLGFNSLPKLNYGNSGSAVRGVIYNNSNSVAKTYLNPPYSVDGWRLDAAQYV 361 Query: 363 LYHHHG 368 + Sbjct: 362 DHQIWS 367 >1UA7-A nrPDB Length = 422 Score = 82.9 bits (203), Expect = 4e-16, Method: Composition-based stats. Identities = 38/174 (21%), Positives = 62/174 (35%), Gaps = 22/174 (12%) Query: 227 IKGLGYNCIQLMAIME---------HAYYASFGYQITSFFAASSRYGTPEELQELVDTAH 277 I GY IQ I + + YQ TS+ + GT +E +E+ A Sbjct: 26 IHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWLYQPTSYQIGNRYLGTEQEFKEMCAAAE 85 Query: 278 SMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGP--RGTHDLWD--------SRLF 327 GI V++D V +H + + A N + H + D WD + Sbjct: 86 EYGIKVIVDAVINHTTFDYAAISNEVKSI-PNWTHGNTQIKNWSDRWDVTQNSLLGLYDW 144 Query: 328 AYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSM-LYHHHGVGQGFSGDYSEY 380 + ++ +L + L + DGFRFD + L G F + + Sbjct: 145 NTQNTQVQSYLKRFLERALND-GADGFRFDAAKHIELPDDGSYGSQFWPNITNT 197 >3HJE-A nrPDB Length = 704 Score = 81.8 bits (200), Expect = 9e-16, Method: Composition-based stats. Identities = 21/95 (22%), Positives = 44/95 (46%), Gaps = 3/95 (3%) Query: 222 NVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGI 281 N L LG + L +++ ++ GY + + + G EE L+D A S G+ Sbjct: 19 NRLDYFVELGVTHLYLSPVLKARPGSTHGYDVVDYNTINDELGGEEEYIRLIDEAKSKGL 78 Query: 282 IVLLDVVHSHASKNSADG--LNMF-DGTDSCYFHS 313 ++ D+V +H + + + +++ G S Y++ Sbjct: 79 GIIQDIVPNHMAVHHTNWRLMDVLKKGRHSRYYNY 113 >3BCF-A nrPDB Length = 599 Score = 79.9 bits (195), Expect = 4e-15, Method: Composition-based stats. Identities = 64/418 (15%), Positives = 114/418 (27%), Gaps = 83/418 (19%) Query: 200 YESHVG-ISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIME-HAYYASFGYQITSFF 257 +E + G ++ + A+ + P + G+ + L + A GY + Sbjct: 131 WEMNTGEYATEHPEEANLWNLLAERAPELAEAGFTAVWLPPANKGMAGIHDVGYGTYDLW 190 Query: 258 A---------ASSRYGTPEELQELVDTAHSMGIIVLLDVVHSH----------------- 291 ++YGT EL+ +D H+ I V D V +H Sbjct: 191 DLGEFDQKGTVRTKYGTKGELENAIDALHNNDIKVYFDAVLNHRMGADYAETVLLDENSR 250 Query: 292 --------------------ASKNSADGLNMFDGTDS---------CYFHSGPRGTHDLW 322 N FDGTD F W Sbjct: 251 DKPGQYIKAWTGFNFPGRNGEYSNFTWNGQCFDGTDWDDYSKESGKYLFDEKSWDWTYNW 310 Query: 323 D-----SRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYH---HHGVGQGFS 374 D Y + + ++ +W + FDGFR D V + Y S Sbjct: 311 DEDYLMGADVDYENEAVQNDVIDWGQWIINNIDFDGFRLDAVKHIDYRFIDKWMSAVQNS 370 Query: 375 GDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYR 434 + +F + + + L V PD V P + G + Sbjct: 371 SNRDVFFVGEAWVEDVDDLKGFLDTVGN--PDL-----RVFDFPLRSFFVDMLNGAYMAD 423 Query: 435 LAMAIPDKWIQL------LKEFKDEDWNMGDIVYTLTNRRYLEKCIAYAESHDQALVGDK 488 L A + D D + G ++ +R+Y + V K Sbjct: 424 LRNAGLVNSPGYENRAVTFVDNHDTDRDEGSYTVSIYSRKYQAYAYILTRAEGVPTVYWK 483 Query: 489 SLAFWLMDAEMYTNMSVLT--PFTPVIDRGIQLHKMIRLITHGLG---GEGYLNFMGN 541 W M + ++ + P + + + G G+G + + + Sbjct: 484 DYYIWEMKEGLDKLLTARRYYAYGPGYEVDNNDADIYSYVRSGFPDVAGDGLVLMISD 541 >3DC0-A nrPDB Length = 422 Score = 78.7 bits (192), Expect = 7e-15, Method: Composition-based stats. Identities = 37/174 (21%), Positives = 63/174 (36%), Gaps = 22/174 (12%) Query: 227 IKGLGYNCIQLMAIME---------HAYYASFGYQITSFFAASSRYGTPEELQELVDTAH 277 I GY IQ I + + YQ TS+ + G+ EE +E+ A Sbjct: 26 IHDAGYTAIQTSPINQVKEGNKGDKSMGNWYWLYQPTSYQIGNRYLGSEEEFKEMCAAAE 85 Query: 278 SMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGP--RGTHDLWD--------SRLF 327 G+ V++D V +H + + A N S + H + D WD + Sbjct: 86 EYGVKVIVDAVINHTTSDYAAISNEIKSI-SNWTHGNTQIKNWSDRWDVTQNSLLGLYDW 144 Query: 328 AYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSM-LYHHHGVGQGFSGDYSEY 380 + ++ +L + L + DGFR+D + L G F + + Sbjct: 145 NTQNTQVQSYLKRFLERALND-GADGFRYDAAKHIELPDDGNYGSQFWPNITNT 197 >1AVA-A nrPDB Length = 403 Score = 78.7 bits (192), Expect = 8e-15, Method: Composition-based stats. Identities = 29/169 (17%), Positives = 55/169 (32%), Gaps = 24/169 (14%) Query: 214 ASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAAS-SRYGTPEELQEL 272 + +F + I G + L + GY + S+YG +L+ L Sbjct: 16 GGWYNFLMGKVDDIAAAGITHVWLPPASQSVAEQ--GYMPGRLYDLDASKYGNKAQLKSL 73 Query: 273 VDTAHSMGIIVLLDVVHSHASKNSADGLNMF---------DGTDSCYFH----------- 312 + H G+ + D+V +H + DG ++ D Sbjct: 74 IGALHGKGVKAIADIVINHRTAEHKDGRGIYCIFEGGTPDARLDWGPHMICRDDRPYADG 133 Query: 313 -SGPRGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVT 360 P D + + + + + L+ + W + FDG+RFD Sbjct: 134 TGNPDTGADFGAAPDIDHLNLRVQKELVEWLNWLKADIGFDGWRFDFAK 182 >4AYS-A nrPDB Length = 648 Score = 78.7 bits (192), Expect = 8e-15, Method: Composition-based stats. Identities = 47/270 (17%), Positives = 80/270 (29%), Gaps = 42/270 (15%) Query: 160 WAKYVVREGDNVNYDWIHWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYKHF 219 A ++ E V H P +R +P L+ E VG ++ + A Sbjct: 49 HADALIGELLEVMLHAYHARPADLKRLDEARLLRPDWLQGPEM-VGYVAYVDRFAGTLRG 107 Query: 220 TCNVLPRIKGLGYN-CIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHS 278 L ++GLG L + GY + + + GT ++L L Sbjct: 108 VGERLEYLEGLGVTYLHLLPLLRPRDGENDGGYAVQDYRSVRPDLGTIDDLSALARELRG 167 Query: 279 MGIIVLLDVVHSHASKNSADGLNMFDGTDSC--YFHSGPRGTHDL--------------- 321 GI ++LD+V +H ++ + G + YFH P T Sbjct: 168 RGISLVLDLVLNHVAEEHEWAVRATAGEAAYRDYFHIFPDRTQPDAYERTLPEIFPDFAP 227 Query: 322 ----WDS--------------RLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSML 363 W+ + + + R L I L + FR D + + Sbjct: 228 GNFTWNGEAGGWVWTTFNRSQWDVNWGNPAVFREYLDLILT-LANRGVEVFRLDAIAFL- 285 Query: 364 YHHHGVGQGFSGDYSEYFGLQVDEDALTYL 393 + E L A T + Sbjct: 286 ---WKRLGTDCQNQPEVHRLTHALRAATRI 312 >5ZCR-A nrPDB Length = 728 Score = 78.7 bits (192), Expect = 9e-15, Method: Composition-based stats. Identities = 20/104 (19%), Positives = 44/104 (42%), Gaps = 2/104 (1%) Query: 220 TCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSM 279 T L K LG + + L I++ ++ GY + + G E +LV A S Sbjct: 19 TIENLDYFKELGVSHLYLSPILKARPGSTHGYDVVDHSEINEELGGEEGYFKLVKEAKSR 78 Query: 280 GIIVLLDVVHSHASKNSADG--LNMFDGTDSCYFHSGPRGTHDL 321 G+ ++ D+V +H + + + +++ + +++ D Sbjct: 79 GLEIIQDIVPNHMAVHHTNWRLMDLLKSWKNSKYYNYFDHYDDD 122 >1IV8-A nrPDB Length = 720 Score = 77.5 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 22/95 (23%), Positives = 49/95 (51%), Gaps = 3/95 (3%) Query: 220 TCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSM 279 + L K LG + + L ++ + ++ GY + + G +E + L++TAH++ Sbjct: 19 VIDNLWYFKDLGVSHLYLSPVLMASPGSNHGYDVIDHSRINDELGGEKEYRRLIETAHTI 78 Query: 280 GIIVLLDVVHSHASKNSADG--LNMFD-GTDSCYF 311 G+ ++ D+V +H + NS + +++ G S Y+ Sbjct: 79 GLGIIQDIVPNHMAVNSLNWRLMDVLKMGKKSKYY 113 >4UZU-A nrPDB Length = 513 Score = 77.5 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 30/223 (13%), Positives = 57/223 (25%), Gaps = 69/223 (30%) Query: 211 GKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFA---------ASS 261 + N + LG + L + + GY + + + Sbjct: 17 PDDGTLWTKVANEANNLSSLGITALWLPPAYKGTSRSDVGYGVYDLYDLGEFNQKGTVRT 76 Query: 262 RYGTPEELQELVDTAHSMGIIVLLDVVHSH------------------------------ 291 +YGT + + + AH+ G+ V DVV H Sbjct: 77 KYGTKAQYLQAIQAAHAAGMQVYADVVFDHKGGADGTEWVDAVEVNPSDRNQEISGTYQI 136 Query: 292 ---ASKNSADGLNMFDGTDSCYFH---------------------------SGPRGTHDL 321 + N + ++H G +D Sbjct: 137 QAWTKFDFPGRGNTYSSFKWRWYHFDGVDWDESRKLSRIYKFRGKAWDWEVDTEFGNYDY 196 Query: 322 WDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLY 364 E++ L + +W++ DGFR D V + + Sbjct: 197 LMYADLDMDHPEVVTELKNWGKWYVNTTNIDGFRLDAVKHIKF 239 >3WN6-A nrPDB Length = 404 Score = 76.0 bits (185), Expect = 5e-14, Method: Composition-based stats. Identities = 29/168 (17%), Positives = 54/168 (32%), Gaps = 23/168 (13%) Query: 214 ASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAAS-SRYGTPEELQEL 272 + +F + I G + L GY + S+YG +L+ L Sbjct: 17 GGWYNFLMGKVDDIAAAGITHVWLPP--PSHSVGEQGYMPGRLYDLDASKYGNEAQLKSL 74 Query: 273 VDTAHSMGIIVLLDVVHSHASKNSADGLNMF---------DGTDSCYFH----------- 312 ++ H G+ V+ D+V +H + DG ++ D Sbjct: 75 IEAFHGKGVQVIADIVINHRTAEHKDGRGIYCLFEGGTPDSRLDWGPHMICRDDPYGDGT 134 Query: 313 SGPRGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVT 360 P D + + + + R L+ + W + FD +R D Sbjct: 135 GNPDTGADFAAAPDIDHLNKRVQRELIGWLDWLKMDIGFDAWRLDFAK 182 >3BSH-A nrPDB Length = 414 Score = 73.3 bits (178), Expect = 3e-13, Method: Composition-based stats. Identities = 28/166 (16%), Positives = 49/166 (29%), Gaps = 24/166 (14%) Query: 214 ASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAAS-SRYGTPEELQEL 272 + + + I G + L ++ GY + S+YG EL+ L Sbjct: 17 GGWYNMMMGKVDDIAAAGVTHVWLPP--PSHSVSNEGYMPGRLYDIDASKYGNAAELKSL 74 Query: 273 VDTAHSMGIIVLLDVVHSH------------------ASKNSADGLNMFDGTDSCYFHSG 314 + H G+ + D+V +H S D D + G Sbjct: 75 IGALHGKGVQAIADIVINHRCADYKDSRGIACIFEGGTSDGRLDWGPHMICRDDTKYSDG 134 Query: 315 PRGTHDLWDSR---LFAYSSWEILRFLLSNIRWWLEEYRFDGFRFD 357 D + + + R L + W + FD +R D Sbjct: 135 TANLDTGADFAAAPDIDHLNDRVQRELKEWLLWLKSDLGFDAWRLD 180 >1BLI-A nrPDB Length = 483 Score = 72.9 bits (177), Expect = 4e-13, Method: Composition-based stats. Identities = 35/208 (16%), Positives = 55/208 (26%), Gaps = 69/208 (33%) Query: 226 RIKGLGYNCIQLMAIMEHAYYASFGYQITSFFA---------ASSRYGTPEELQELVDTA 276 + G + + + A GY + ++YGT ELQ + + Sbjct: 31 YLAEHGITAVWIPPAYKGTSQADVGYGAYDLYDLGEFHQKGTVRTKYGTKGELQSAIKSL 90 Query: 277 HSMGIIVLLDVVHSH-------------------------------------------AS 293 HS I V DVV +H Sbjct: 91 HSRDINVYGDVVINHKGGADATEDVTAVEVDPADRNRVISGEHLIKAWTHFHFPGRGSTY 150 Query: 294 KNSADGLNMFDGTD-----------------SCYFHSGPRGTHDLWDSRLFAYSSWEILR 336 + FDGTD + S G +D Y ++ Sbjct: 151 SDFKWHWYHFDGTDWDESRKLNRIYKFQGKAWDWEVSNEFGNYDYLMYADIDYDHPDVAA 210 Query: 337 FLLSNIRWWLEEYRFDGFRFDGVTSMLY 364 + W+ E + DGFR D V + + Sbjct: 211 EIKRWGTWYANELQLDGFRLDAVKHIKF 238 >1E3X-A nrPDB Length = 483 Score = 72.1 bits (175), Expect = 7e-13, Method: Composition-based stats. Identities = 59/410 (14%), Positives = 111/410 (27%), Gaps = 93/410 (22%) Query: 222 NVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFA---------ASSRYGTPEELQEL 272 N + +G + + + + GY + ++YGT ELQ+ Sbjct: 25 NDAEHLSDIGITAVWIPPAYKGLSQSDNGYGPYDLYDLGEFQQKGTVRTKYGTKSELQDA 84 Query: 273 VDTAHSMGIIVLLDVVHSH---------------------------------ASKNSADG 299 + + HS + V DVV +H Sbjct: 85 IGSLHSRNVQVYGDVVLNHKAGADATEDVTAVEVNPANRNQETSEEYQIKAWTDFRFPGR 144 Query: 300 LNMFDGTDSCYFH-----------------------------SGPRGTHDLWDSRLFAYS 330 N + ++H S G +D Y Sbjct: 145 GNTYSDFKWHWYHFDGADWDESRKISRIFKFRGEGKAWDWEVSSENGNYDYLMYADVDYD 204 Query: 331 SWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDAL 390 +++ W+ E DGFR D + + + Sbjct: 205 HPDVVAETKKWGIWYANELSLDGFRIDAAKHIKFSF----LRDWVQAVRQATGKEMFTVA 260 Query: 391 TYLMLANHLVHTLCPDSITIAEDVSGMPA--LCSPISQGGGGFDYRLAMAIPDKWIQLLK 448 Y N + + + V +P S GGG+D R + LK Sbjct: 261 EYWQN-NAGKLENYLNKTSFNQSVFDVPLHFNLQAASSQGGGYDMRKLLNGTVVSKHPLK 319 Query: 449 EFKDEDWNMGDIVYTL-TNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLT 507 D + +L + + K +AYA ++ +S + +MY Sbjct: 320 SVTFVDNHDTQPGQSLESTVQTWFKPLAYAF-----ILTRESGYPQVFYGDMYGTKGDSQ 374 Query: 508 PFTPVIDRGIQ-LHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGN 556 P + I+ + K + +G + F H + + + R+G+ Sbjct: 375 REIPALKHKIEPILKARKQYAYGAQH--------DYFDHHDIVGWTREGD 416 >6GXV-A nrPDB Length = 484 Score = 72.1 bits (175), Expect = 8e-13, Method: Composition-based stats. Identities = 29/210 (13%), Positives = 55/210 (26%), Gaps = 70/210 (33%) Query: 225 PRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFA---------ASSRYGTPEELQELVDT 275 +K +G + + + GY + + ++YGT +LQ + + Sbjct: 32 SHLKSIGITGVWFPPAYKGQSQSDVGYGVYDMYDLGEFNQKGTVRTKYGTKAQLQSAITS 91 Query: 276 AHSMGIIVLLDVVHSH-------------------------------------------A 292 H+ GI DVV +H Sbjct: 92 LHNNGIQAYGDVVLNHRMGADATETISAVEVNPSNRNQVTSGAYNISAWTDFEFPGRGNT 151 Query: 293 SKNSADGLNMFDGTD------------------SCYFHSGPRGTHDLWDSRLFAYSSWEI 334 + FDG D + G +D Y ++ Sbjct: 152 YSSFKWHSYYFDGVDWDQSRQLSGKIYQIQGKAWDWEVDSENGNYDYLMGADIDYDHPDV 211 Query: 335 LRFLLSNIRWWLEEYRFDGFRFDGVTSMLY 364 + + +W++ DG R D V + + Sbjct: 212 QTEVKNWGKWFVNTLNLDGVRLDAVKHIKF 241 >6IRT-A nrPDB Length = 647 Score = 71.0 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 33/238 (13%), Positives = 68/238 (28%), Gaps = 46/238 (19%) Query: 210 EGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEEL 269 +G A L + L + L I ++ T +G+ E+ Sbjct: 249 QGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDV---AQTDLLQIDPNFGSKEDF 305 Query: 270 QELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRLFAY 329 L+ +A I V+LD+ ++ +NS W F+ Sbjct: 306 DSLLQSAKKKSIRVILDLTPNYRGENS-------------------------W----FST 336 Query: 330 SSWEILRFLLSNIRWWLEEYRFDGFRF-------DGVTSMLYHHHGVGQGFSGDYSEYFG 382 + + + +WL+ DGF+ D + + + Sbjct: 337 QVDTVATKVKDALEFWLQ-AGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGT 395 Query: 383 LQVDEDALTYLMLANHLVH---TLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAM 437 D + L+ +N + + DS + E +L + G ++ Sbjct: 396 NSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTK---SLVTQYLNATGNRWCSWSL 450 >1MXD-A nrPDB Length = 435 Score = 71.0 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 42/191 (21%), Positives = 67/191 (35%), Gaps = 31/191 (16%) Query: 231 GYNCIQLMAIME-HAYYASFGYQITSFFA---------ASSRYGTPEELQELVDTAHSMG 280 G + I L + + S GY +F +R+G+ EEL L+ TAH+ G Sbjct: 41 GISAIWLPPPSKGMSGGYSMGYDPYDYFDLGEYYQKGTVETRFGSKEELVRLIQTAHAYG 100 Query: 281 IIVLLDVVHSH-ASKNSADGLNMFDGTDSCY--------------FHSGPR--GTHDLWD 323 I V+ DVV +H A + + D T + + FH + Sbjct: 101 IKVIADVVINHRAGGDLEWNPFVGDYTWTDFSKVASGKYTANYLDFHPNELHCCDEGTFG 160 Query: 324 SRLFAYSSWEILRFLL----SNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSE 379 E ++ L + +L FDG+RFD V + G ++ Sbjct: 161 GFPDICHHKEWDQYWLWKSNESYAAYLRSIGFDGWRFDYVKGYGAWVVRDWLNWWGGWAV 220 Query: 380 YFGLQVDEDAL 390 + DAL Sbjct: 221 GEYWDTNVDAL 231 >3BH4-A nrPDB Length = 483 Score = 71.0 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 30/214 (14%), Positives = 54/214 (25%), Gaps = 71/214 (33%) Query: 222 NVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFA---------ASSRYGTPEELQEL 272 N + +G + + + + GY + ++YGT ELQ+ Sbjct: 25 NDAEHLSDIGITAVWIPPAYKGLSQSDNGYGPYDLYDLGEFQQKGTVRTKYGTKSELQDA 84 Query: 273 VDTAHSMGIIVLLDVVHSH---------------------------------ASKNSADG 299 + + HS + V DVV +H Sbjct: 85 IGSLHSRNVQVYGDVVLNHKAGADATEDVTAVEVNPANRNQETSEEYQIKAWTDFRFPGR 144 Query: 300 LNMFDGTDSCYFH-----------------------------SGPRGTHDLWDSRLFAYS 330 N + ++H S G +D Y Sbjct: 145 GNTYSDFKWHWYHFDGADWDESRKISRIFKFRGEGKAWDWEVSSENGNYDYLMYADVDYD 204 Query: 331 SWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLY 364 +++ W+ E DGFR D + + Sbjct: 205 HPDVVAETKKWGIWYANELSLDGFRIDAAKHIKF 238 >2DH2-A nrPDB Length = 424 Score = 69.8 bits (169), Expect = 4e-12, Method: Composition-based stats. Identities = 33/238 (13%), Positives = 68/238 (28%), Gaps = 46/238 (19%) Query: 210 EGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEEL 269 +G A L + L + L I ++ T +G+ E+ Sbjct: 28 QGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDV---AQTDLLQIDPNFGSKEDF 84 Query: 270 QELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRLFAY 329 L+ +A I V+LD+ ++ +NS W F+ Sbjct: 85 DSLLQSAKKKSIRVILDLTPNYRGENS-------------------------W----FST 115 Query: 330 SSWEILRFLLSNIRWWLEEYRFDGFRF-------DGVTSMLYHHHGVGQGFSGDYSEYFG 382 + + + +WL+ DGF+ D + + + Sbjct: 116 QVDTVATKVKDALEFWLQ-AGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGT 174 Query: 383 LQVDEDALTYLMLANHLVH---TLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAM 437 D + L+ +N + + DS + E +L + G ++ Sbjct: 175 NSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTK---SLVTQYLNATGNRWCSWSL 229 >1UD8-A nrPDB Length = 480 Score = 69.8 bits (169), Expect = 4e-12, Method: Composition-based stats. Identities = 44/357 (12%), Positives = 86/357 (24%), Gaps = 114/357 (31%) Query: 200 YESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFA- 258 YE H+ + G I + + A GY + Sbjct: 11 YEWHLENDGQHWNRLHDDAAA------LSDAGITAIWIPPAYKGNSQADVGYGAYDLYDL 64 Query: 259 --------ASSRYGTPEELQELVDTAHSMGIIVLLDVVHSH------------------- 291 ++YGT +L+ + + S I V DVV +H Sbjct: 65 GEFNQKGTVRTKYGTKAQLERAIGSLKSNDINVYGDVVMNHKMGADFTEAVQAVQVNPTN 124 Query: 292 --------------ASKNSADGLNMFDGTDSCYFH------------------------- 312 + + N + +FH Sbjct: 125 RWQDISGAYTIDAWTGFDFSGRNNAYSDFKWRWFHFNGVDWDQRYQENHIFRFANTNWNW 184 Query: 313 --SGPRGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVG 370 G +D +S E+ L W+ +E DG+R D + + + + Sbjct: 185 RVDEENGNYDYLLGSNIDFSHPEVQDELKDWGSWFTDELDLDGYRLDAIKHIPFWYTSDW 244 Query: 371 QGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPISQGGGG 430 H + D + E G Sbjct: 245 -------------------------VRHQRNEADQDLFVVGEYWKD--------DVGALE 271 Query: 431 F---DYRLAMAIPDKWIQLLKEFKDED---WNMGDIVYTLTNRRYLEKCIAYAESHD 481 F + M++ D + + ++M +I+ + + + ++HD Sbjct: 272 FYLDEMNWEMSLFDVPLNYNFYRASQQGGSYDMRNILRGSLVEAHPMHAVTFVDNHD 328 >3QGV-A nrPDB Length = 435 Score = 67.5 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 35/216 (16%), Positives = 62/216 (28%), Gaps = 31/216 (14%) Query: 206 ISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIME-HAYYASFGYQITSFFA------ 258 + +P G + I + + S GY FF Sbjct: 16 FYWDVPSGGIWWDTIRQKIPEWYDAGISAIWIPPASKGMGGAYSMGYDPYDFFDLGEYDQ 75 Query: 259 ---ASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNS------------ADGLNMF 303 +R+G+ +EL +++TAH+ G+ V+ D+V +H + D + Sbjct: 76 KGTVETRFGSKQELVNMINTAHAYGMKVIADIVINHRAGGDLEWNPFVNDYTWTDFSKVA 135 Query: 304 DGTDSCYFHSGPRGTHDLWDSRLFAYSSWEILRFLLSNIRWW---------LEEYRFDGF 354 G + + DS F W L D + Sbjct: 136 SGKYTANYLDFHPNELHAGDSGTFGGYPDICHDKSWDQYWLWASQESYAAYLRSIGIDAW 195 Query: 355 RFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDAL 390 RFD V + G ++ + DA+ Sbjct: 196 RFDYVKGYAPWVVKDWLNWWGGWAVGEYWDTNVDAV 231 >5CIM-A nrPDB Length = 698 Score = 67.5 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 46/244 (18%), Positives = 78/244 (31%), Gaps = 36/244 (14%) Query: 155 YRISPWAKYVVREGDNVNYDWIHWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGK-V 213 A+Y +RE + W F PRS G EG+ V Sbjct: 197 EVSDLLAEYPLREFVTRGEQYGVWVDRPEARFSSWYEMFPRST-------GGWDAEGRPV 249 Query: 214 ASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGY-------------------QIT 254 LPRI +G++ + L I G Sbjct: 250 HGTFATAAEALPRIARMGFDVVYLPPIHPIGKVHRKGRNNSVTAAPGDVGSPWAIGSDEG 309 Query: 255 SFFAASSRYGTPEELQELVDTAHSMGIIVLLDV----VHSHA-SKNSADGLNMFDGTDSC 309 A + GT E+ E V +A +G+ V LD+ H ++ + + Sbjct: 310 GHDAVHPQLGTIEDFDEFVASARDLGLEVALDLALQCAPDHPWAREHPEWFTVLPDGSIA 369 Query: 310 YFHSGPRGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSML--YHHH 367 Y + P+ D++ F I + +L +R+W+ + + FR D + + Sbjct: 370 YAENPPKKYQDIYPLN-FDNDPAGIYQEVLRVVRFWIS-HGVNIFRVDNPHTKPPNFWAW 427 Query: 368 GVGQ 371 +GQ Sbjct: 428 LIGQ 431 >4CN6-A nrPDB Length = 695 Score = 64.1 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 28/192 (14%), Positives = 51/192 (26%), Gaps = 40/192 (20%) Query: 207 SSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQIT------------ 254 + G + LP I +G++ + L I G T Sbjct: 246 HTPHGTFRT----AARRLPAIAAMGFDVVYLPPIHPIGTTHRKGRNNTLSATGDDVGVPW 301 Query: 255 -------SFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTD 307 + GT ++ V A +G+ + LD S + Sbjct: 302 AIGSPEGGHDSIHPALGTLDDFDHFVTEAGKLGLEIALDFALQ-CSPDHPW-----VHKH 355 Query: 308 SCYFHSGPRGTHDLWDSRL----------FAYSSWEILRFLLSNIRWWLEEYRFDGFRFD 357 +FH P GT ++ F + + +R W+ ++ FR D Sbjct: 356 PEWFHHRPDGTIAHAENPPKKYQDIYPIAFDADPDGLATETVRILRHWM-DHGVRIFRVD 414 Query: 358 GVTSMLYHHHGV 369 + Sbjct: 415 NPHTKPVAFWER 426 >1GCY-A nrPDB Length = 527 Score = 62.9 bits (151), Expect = 5e-10, Method: Composition-based stats. Identities = 31/148 (20%), Positives = 48/148 (32%), Gaps = 21/148 (14%) Query: 231 GYNCIQLMAI----MEHAYYASF-----GYQITSFFAASSRYGTPEELQELVDTAHSMGI 281 G++ I M + S GY F + RYG+ +L++ G+ Sbjct: 50 GFSAIW-MPVPWRDFSSWSDGSKSGGGEGYFWHDFNK-NGRYGSDAQLRQAASALGGAGV 107 Query: 282 IVLLDVVHSHASKNSAD---------GLNMFDGTDS-CYFHSGPRGTHDLWDSRLFAYSS 331 VL DVV +H ++ D G D D Y + G + Sbjct: 108 KVLYDVVPNHMNRGYPDKEINLPAGQGFWRNDCADPGNYPNDCDDGDRFIGGDADLNTGH 167 Query: 332 WEILRFLLSNIRWWLEEYRFDGFRFDGV 359 ++ +Y GFRFD V Sbjct: 168 PQVYGMFRDEFTNLRSQYGAGGFRFDFV 195 >4U33-A nrPDB Length = 723 Score = 62.5 bits (150), Expect = 6e-10, Method: Composition-based stats. Identities = 32/198 (16%), Positives = 59/198 (29%), Gaps = 28/198 (14%) Query: 205 GISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQ------ITSFFA 258 G V LPRI G+G++ + L I G T + Sbjct: 266 GWDDDGNPVHGTFATAAAELPRIAGMGFDVVYLPPIHPIGKVHRKGRNNSPTAAPTDVGS 325 Query: 259 A-------------SSRYGTPEELQELVDTAHSMGIIVLLDV----VHSHA-SKNSADGL 300 GT ++ + V A +G+ V LD+ H ++ Sbjct: 326 PWAIGSDEGGHDTVHPSLGTIDDFDDFVSAARDLGMEVALDLALQCAPDHPWAREHRQWF 385 Query: 301 NMFDGTDSCYFHSGPRGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVT 360 Y + P+ D++ F + +L ++ W+ + FR D Sbjct: 386 TELPDGTIAYAENPPKKYQDIYPLN-FDNDPEGLYDEVLRVVQHWV-NHGVKFFRVDNPH 443 Query: 361 SML--YHHHGVGQGFSGD 376 + + + Q + D Sbjct: 444 TKPPNFWAWLIAQVKTVD 461 >2D3L-A nrPDB Length = 485 Score = 62.1 bits (149), Expect = 8e-10, Method: Composition-based stats. Identities = 32/212 (15%), Positives = 52/212 (24%), Gaps = 72/212 (33%) Query: 225 PRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFA---------ASSRYGTPEELQELVDT 275 +K G + + + A GY + ++YGT +LQ V + Sbjct: 32 SNLKSKGITAVWIPPAWKGASQNDVGYGAYDLYDLGEFNQKGTVRTKYGTRSQLQAAVTS 91 Query: 276 AHSMGIIVLLDVVHSH---------------------------------ASKNSADGLNM 302 + GI V DVV +H + N Sbjct: 92 LKNNGIQVYGDVVMNHKGGADATEMVRAVEVNPNNRNQEVTGEYTIEAWTRFDFPGRGNT 151 Query: 303 FDGTDSCYFH------------------------------SGPRGTHDLWDSRLFAYSSW 332 ++H G +D Sbjct: 152 HSSFKWRWYHFDGVDWDQSRRLNNRIYKFRGHGKAWDWEVDTENGNYDYLMYADIDMDHP 211 Query: 333 EILRFLLSNIRWWLEEYRFDGFRFDGVTSMLY 364 E++ L + W+ DGFR D V + Y Sbjct: 212 EVVNELRNWGVWYTNTLGLDGFRIDAVKHIKY 243 >1QI5-A nrPDB Length = 429 Score = 61.7 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 30/148 (20%), Positives = 47/148 (31%), Gaps = 21/148 (14%) Query: 231 GYNCIQLMAI---------MEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGI 281 G++ I M + GY F + RYG+ +L++ G+ Sbjct: 50 GFSAIW-MPVPWRDFSSWSDGSKSGGGEGYFWHDFNK-NGRYGSDAQLRQAASALGGAGV 107 Query: 282 IVLLDVVHSHASKNSAD---------GLNMFDGTDS-CYFHSGPRGTHDLWDSRLFAYSS 331 VL DVV +H ++ D G D D Y + G + Sbjct: 108 KVLYDVVPNHMNRGYPDKEINLPAGQGFWRNDCADPGNYPNDCDDGDRFIGGDADLNTGH 167 Query: 332 WEILRFLLSNIRWWLEEYRFDGFRFDGV 359 ++ +Y GFRFD V Sbjct: 168 PQVYGMFRDEFTNLRSQYGAGGFRFDFV 195 >2GJP-A nrPDB Length = 485 Score = 60.2 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 28/212 (13%), Positives = 50/212 (23%), Gaps = 72/212 (33%) Query: 225 PRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFA---------ASSRYGTPEELQELVDT 275 ++ G I + + GY + ++YGT +L+ + Sbjct: 32 SNLRNRGITAIWIPPAWKGTSQNDVGYGAYDLYDLGEFNQKGTVRTKYGTRSQLESAIHA 91 Query: 276 AHSMGIIVLLDVVHSH---------------------------------ASKNSADGLNM 302 + G+ V DVV +H + N Sbjct: 92 LKNNGVQVYGDVVMNHKGGADATENVLAVEVNPNNRNQEISGDYTIEAWTKFDFPGRGNT 151 Query: 303 FDGTDSCYFH------------------------------SGPRGTHDLWDSRLFAYSSW 332 + ++H G +D Sbjct: 152 YSDFKWRWYHFDGVDWDQSRQFQNRIYKFRGDGKAWDWEVDSENGNYDYLMYADVDMDHP 211 Query: 333 EILRFLLSNIRWWLEEYRFDGFRFDGVTSMLY 364 E++ L W+ DGFR D V + Y Sbjct: 212 EVVNELRRWGEWYTNTLNLDGFRIDAVKHIKY 243 >2DIE-A nrPDB Length = 485 Score = 59.8 bits (143), Expect = 4e-09, Method: Composition-based stats. Identities = 31/210 (14%), Positives = 51/210 (24%), Gaps = 72/210 (34%) Query: 227 IKGLGYNCIQLMAIMEHAYYASFGYQITSFFA---------ASSRYGTPEELQELVDTAH 277 +K G + + + GY + ++YGT +LQ V + Sbjct: 34 LKSKGITAVWIPPAWKGTSQNDVGYGAYDLYDLGEFNQKGTVRTKYGTRSQLQGAVTSLK 93 Query: 278 SMGIIVLLDVVHSH---------------------------------ASKNSADGLNMFD 304 + GI V DVV +H + N Sbjct: 94 NNGIQVYGDVVMNHKGGADGTEMVNAVEVNRSNRNQEISGEYTIEAWTKFDFPGRGNTHS 153 Query: 305 GTDSCYFHSG------------------------------PRGTHDLWDSRLFAYSSWEI 334 ++H G +D E+ Sbjct: 154 NFKWRWYHFDGTDWDQSRQLQNKIYKFRGTGKAWDWEVDIENGNYDYLMYADIDMDHPEV 213 Query: 335 LRFLLSNIRWWLEEYRFDGFRFDGVTSMLY 364 + L + W+ DGFR D V + Y Sbjct: 214 INELRNWGVWYTNTLNLDGFRIDAVKHIKY 243 >1BPL-A nrPDB Length = 189 Score = 57.5 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 19/81 (23%), Positives = 29/81 (35%), Gaps = 9/81 (11%) Query: 226 RIKGLGYNCIQLMAIMEHAYYASFGYQITSFFA---------ASSRYGTPEELQELVDTA 276 + G + + + A GY + ++YGT ELQ + + Sbjct: 31 YLAEHGITAVWIPPAYKGTSQADVGYGAYDLYDLGEFHQKGTVRTKYGTKGELQSAIKSL 90 Query: 277 HSMGIIVLLDVVHSHASKNSA 297 HS I V DVV +H A Sbjct: 91 HSRDINVYGDVVINHKGGADA 111 >1GJU-A nrPDB Length = 637 Score = 57.1 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 39/225 (17%), Positives = 67/225 (29%), Gaps = 43/225 (19%) Query: 157 ISPWAKYVVREGDNVNYDWIHWDPEHSYEFKHSRPKK------------PRSLRIYESHV 204 + P+ D + WD F PR+ Y Sbjct: 43 VDPYELGAEI-TDWILNQSREWDYSQPLSFLKGEKTPDWIKRSVVYGSLPRTTAAYNHKG 101 Query: 205 GISSHEGKVASYKHFTC-----NVLPRIKGLGYNCIQLMAIMEHAYYASFG-----YQIT 254 E V ++ +LP +K LG + I L+ + + G Y + Sbjct: 102 SGYYEENDVLGFREAGTFFKMMLLLPFVKSLGADAIYLLPVSRMSDLFKKGDAPSPYSVK 161 Query: 255 SFFAASSRYGTP--------EELQELVDTAHSMGIIVLLDVVHSHASKN------SADGL 300 + RY P EE + V+ H +GI V+LD + A+++ D Sbjct: 162 NPMELDERYHDPLLEPFKVDEEFKAFVEACHILGIRVILDFIPRTAARDSDLIREHPDWF 221 Query: 301 NMFDGTDSCYFHSGPRGTH-----DLWDSRLFAYSSWEILRFLLS 340 + + ++ PR D Y+ + R L Sbjct: 222 -YWIKVEELADYTPPRAEELPFKVPDEDELEIIYNKENVKRHLKK 265 Score = 32.1 bits (71), Expect = 0.78, Method: Composition-based stats. Identities = 10/53 (18%), Positives = 20/53 (37%) Query: 329 YSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYF 381 + E+ +L I + ++Y DG R D ++ + +Y F Sbjct: 357 EPNRELWEYLAGVIPHYQKKYGIDGARLDMGHALPKELLDLIIKNVKEYDPAF 409 >1MFU-A nrPDB Length = 491 Score = 56.7 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 42/305 (13%), Positives = 89/305 (29%), Gaps = 55/305 (18%) Query: 226 RIKGLGYNCIQLMAIMEH-----AYYASF-GYQITSFFAASSRYGTPEELQELVDTAHSM 279 + G+ +Q+ E+ + + YQ S+ +R G +E + +V +++ Sbjct: 31 YLAPKGFGGVQVSPPNENVAIHNPFRPWWERYQPVSY-KLCTRSGNEDEFRNMVTRCNNV 89 Query: 280 GIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGT----HDLWDSR---------- 325 G+ + +D V +H N+ T YF+ G R + WD Sbjct: 90 GVRIYVDAVINHMCGNAVSAGT--SSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGD 147 Query: 326 -------------------LFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSM---- 362 A + + + + + GFR D M Sbjct: 148 IENYNDATQVRDCRLSGLLDLALGKDYVRSKIAEYMNHLI-DIGVAGFRIDASKHMWPGD 206 Query: 363 ----LYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMP 418 L H + + + S+ F Q D + ++ +T + + + Sbjct: 207 IKAILDKLHNLNSNWFPEGSKPFIYQEVIDLGGEPIKSSDYFGN---GRVTEFKYGAKLG 263 Query: 419 ALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNM-GDIVYTLTNRRYLEKCIAYA 477 + + + F D N G + T + R + + + Sbjct: 264 TVIRKWNGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRGHSILTFWDARLYKMAVGFM 323 Query: 478 ESHDQ 482 +H Sbjct: 324 LAHPY 328 >1JD7-A nrPDB Length = 453 Score = 56.0 bits (133), Expect = 6e-08, Method: Composition-based stats. Identities = 26/159 (16%), Positives = 55/159 (34%), Gaps = 22/159 (13%) Query: 225 PRIKGLGYNCIQLMAIMEHAYYASF--GYQITSFFAASSRYGTPEELQELVDTAHSMGII 282 + GY +Q+ EH + + YQ S+ SR G + ++V+ + G+ Sbjct: 22 QYLGPKGYAAVQVSPPNEHITGSQWWTRYQPVSY-ELQSRGGNRAQFIDMVNRCSAAGVD 80 Query: 283 VLLDVVHSH------ASKNSADGLNMFDGTDSCY-FHSGPRGTHDLWDSRLFAYSSWEI- 334 + +D + +H N S FH + + + + + E+ Sbjct: 81 IYVDTLINHMAAGSGTGTAGNSFGNKSFPIYSPQDFHESCTINNSDYGNDRYRVQNCELV 140 Query: 335 --------LRFLLSNIRWWLEEY---RFDGFRFDGVTSM 362 ++ + I ++ + GFRFD + Sbjct: 141 GLADLDTASNYVQNTIAAYINDLQAIGVKGFRFDASKHV 179 >1TMQ-A nrPDB Length = 471 Score = 55.6 bits (132), Expect = 7e-08, Method: Composition-based stats. Identities = 25/162 (15%), Positives = 51/162 (31%), Gaps = 27/162 (16%) Query: 226 RIKGLGYNCIQLMAIMEHAYYASF----GYQITSFFAASSRYGTPEELQELVDTAHSMGI 281 ++ G+ +Q+ E+ YQ S+ ++R G ++ + G+ Sbjct: 31 FLQPQGFGGVQISPPNEYLVADGRPWWERYQPVSY-IINTRSGDESAFTDMTRRCNDAGV 89 Query: 282 IVLLDVVHSH-ASKNSADGLNMFDGTDSCYFHSGPRGT-----------HDLWDS----- 324 + +D V +H N D + + P G+ + D+ Sbjct: 90 RIYVDAVINHMTGMNGVGTSGSSADHDGMNYPAVPYGSGDFHSPCEVNNYQDADNVRNCE 149 Query: 325 ----RLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSM 362 R S + L+ + + + GFR D M Sbjct: 150 LVGLRDLNQGSDYVRGVLIDYMNHMI-DLGVAGFRVDAAKHM 190 >3AIC-A nrPDB Length = 844 Score = 50.2 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 21/113 (18%), Positives = 39/113 (34%), Gaps = 12/113 (10%) Query: 190 RPKKPRSLRIYESHVGISSHEGKVASYKHFTCNV-LPRIKGLGYNCIQLMAIMEHAYYAS 248 + S ++E + K Y + + + G ++ + S Sbjct: 604 QNAALDSRVMFEGFSNFQAFATKKEEYTNVVIAKNVDKFAEWGVTDFEMAPQYVSSTDGS 663 Query: 249 F-------GYQITSFFAAS----SRYGTPEELQELVDTAHSMGIIVLLDVVHS 290 F GY T + ++YGT ++L + + HS GI V+ D V Sbjct: 664 FLDSVIQNGYAFTDRYDLGISKPNKYGTADDLVKAIKALHSKGIKVMADWVPD 716 >3VM5-A nrPDB Length = 505 Score = 49.4 bits (116), Expect = 6e-06, Method: Composition-based stats. Identities = 27/169 (15%), Positives = 54/169 (31%), Gaps = 39/169 (23%) Query: 231 GYNCIQLMAIMEH-----AYYASFG-YQITSFFAASSRYGTPEELQELVDTAHSMGIIVL 284 G+ +Q+ EH + + YQ S+ SR G EL++++ +++G+ V Sbjct: 36 GFAGVQISPPNEHILVSSPWRPWWQRYQPISYN-LCSRSGGENELRDMITRCNNVGVNVY 94 Query: 285 LDVVHSH-----ASKNSADGLNMFDGTDSCYFHSGP-------RGTHDLWDSRLFAYSSW 332 +D V +H + + + ++ F S P G + Y Sbjct: 95 VDAVINHMCGAGGGEGTHSSCGSWFNANNKDFPSVPYSNLDFNDGKCKTGSGNIENYGDP 154 Query: 333 -------------------EILRFLLSNIRWWLEEYRFDGFRFDGVTSM 362 + + + + + GFR D M Sbjct: 155 YQVRDCRLVGLLDLALEKDYVRGKVADFMNKLI-DMGVAGFRVDACKHM 202 >3L2M-A nrPDB Length = 496 Score = 48.6 bits (114), Expect = 9e-06, Method: Composition-based stats. Identities = 24/173 (13%), Positives = 55/173 (31%), Gaps = 37/173 (21%) Query: 226 RIKGLGYNCIQLMA-----IMEHAYYASF-GYQITSFFAASSRYGTPEELQELVDTAHSM 279 + G+ +Q+ ++ + + YQ S+ +R G E +++V +++ Sbjct: 31 YLGPKGFGGVQVSPPNENIVVTNPSRPWWERYQPVSY-KLCTRSGNENEFRDMVTRCNNV 89 Query: 280 GIIVLLDVVHSH------------ASKNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRLF 327 G+ + +D V +H + + N G + Sbjct: 90 GVRIYVDAVINHMCGSGAAAGTGTTCGSYCNPGNREFPAVPYSAWDFNDGKCKTASGGIE 149 Query: 328 AYSSW-EIL--------------RFLLSNIRWWLEEY---RFDGFRFDGVTSM 362 +Y+ ++ ++ S I +L + GFR D M Sbjct: 150 SYNDPYQVRDCQLVGLLDLALEKDYVRSMIADYLNKLIDIGVAGFRIDASKHM 202 >5JBE-A nrPDB Length = 854 Score = 47.5 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 21/128 (16%), Positives = 40/128 (31%), Gaps = 11/128 (8%) Query: 174 DWIHWDPEHSYEFKHSRPKKPRSL---RIYESHVGISSHEGKVASYKHFTCNVLPRI-KG 229 + + K + +L IYE V ++ + + Sbjct: 596 QDVTTNASDVVANKEKTFESNAALDSHMIYEDFSLFQPEPTSVENHAYNVIAKNASLFSD 655 Query: 230 LGYNCIQLMAIMEH--AYYASFGYQITSFFAASS-----RYGTPEELQELVDTAHSMGII 282 LG + + GY +T + + +YG+ EEL + H G+ Sbjct: 656 LGITDFWMAPAYTPFGRSRYNEGYSMTDRYNLGTTANPTKYGSGEELANTIAALHKAGLK 715 Query: 283 VLLDVVHS 290 V D+V + Sbjct: 716 VQEDIVMN 723 >5C8B-B nrPDB Length = 514 Score = 44.4 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 16/81 (19%), Positives = 35/81 (43%), Gaps = 6/81 (7%) Query: 232 YNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSH 291 Y+ + ++ A G+ R G+ +++ EL T H+ +++D + +H Sbjct: 36 YDGVHILPFFTPFDGADAGFDPIDHTKVDERLGSWDDVAELSKT-HN----IMVDAIVNH 90 Query: 292 ASKNSADGLNMF-DGTDSCYF 311 S S ++ G +S Y+ Sbjct: 91 MSWESKQFQDVLAKGEESEYY 111 >5X3I-A nrPDB Length = 743 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 28/160 (17%), Positives = 50/160 (31%), Gaps = 14/160 (8%) Query: 229 GLGYNCIQLMAIMEHAYYASFGYQITSF-FAASSRYGTPEELQELVDTAHSMGIIVLLDV 287 G I A+ S ++ F + + P + ++D H+ GI V+L Sbjct: 339 EQGIT-IWRDAVYAVTEDGS-AHRAEDFSYRPDGAWPDP---KAMIDELHARGIKVILWQ 393 Query: 288 VHSH-----ASKNSADGLNMFDGTDSCYFHSGPRGTHDLW---DSRLFAYSSWEILRFLL 339 + + +AD M + G + W + + S + Sbjct: 394 IPLQKTEFSTGQVAADAAAMVRDGHAVLEADGTAYRNRGWWFPQALMPDLSVQRTRDWWT 453 Query: 340 SNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSE 379 R+ +E + DGF+ G H G GD Sbjct: 454 EKRRYLVEHFDVDGFKTAGGEHAWGHDLVYADGRKGDEGN 493 >1BPL-B nrPDB Length = 294 Score = 40.2 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 11/49 (22%), Positives = 19/49 (38%) Query: 316 RGTHDLWDSRLFAYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLY 364 G +D Y ++ + W+ E + DGFR D V + + Sbjct: 1 NGNYDYLMYADIDYDHPDVAAEIKRWGTWYANELQLDGFRLDAVKHIKF 49 >5I0E-B nrPDB Length = 733 Score = 39.0 bits (89), Expect = 0.007, Method: Composition-based stats. Identities = 22/117 (18%), Positives = 37/117 (31%), Gaps = 9/117 (7%) Query: 272 LVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDG---TDSCYFHSGPRGTHD----LWDS 324 ++ H GI V+L + + + + G S + P GT W Sbjct: 373 MIRELHERGIRVILWQIPLQKTDDDLGPEALAQGNALIASGHVVKEPDGTPYKNRGWWFP 432 Query: 325 RLF--AYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSE 379 S+ ++ R+ +E+ DGF+ DG G GD Sbjct: 433 NALMPDLSTEAGRQWWTEQRRYLVEDLDIDGFKTDGGEHAWGSDLRYEDGRRGDEGN 489 >5WZN-A nrPDB Length = 640 Score = 36.3 bits (82), Expect = 0.048, Method: Composition-based stats. Identities = 46/304 (15%), Positives = 82/304 (26%), Gaps = 55/304 (18%) Query: 227 IKGLGYNCIQLMAIMEHAYYASFGYQI--TSFFAASSRYGTPEELQELVDTAHSMGIIVL 284 + +G + L +A GY + A G + ++ L+D H G Sbjct: 309 LHEMGAGRLYL----HLDGWAQPGYDNGHPDYLPACREAGGWKGMKSLIDACHEQG---- 360 Query: 285 LDVVHSHASKNSADG-LNMFDGTDSCYFHSGPRGTHDLWDSRLFAYSSWE-----ILRFL 338 D+ +H FD ++ G H +W Y E + R Sbjct: 361 -DLFGTHDQYRDYYFAARTFDPRNAIRLADGTMPEHAMWAGGRQTYLCAELAPDYVRRNF 419 Query: 339 LSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANH 398 G D +G + E+ + + Y A Sbjct: 420 SEIATH--------GIVLDCA---YLDVFTCNEGDECSHPEHRMTRRE----CYERRAEC 464 Query: 399 LVHTLCPDSITIAEDVSGM--PALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWN 456 + L +T +E+VS P+L Y M PD Sbjct: 465 FEYLLAHGILTSSEEVSDWAVPSLVFCHYA-----PYDFQMRSPDAPRH----------G 509 Query: 457 MGDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRG 516 + +Y L C+ D+ GD + + L++ + +D Sbjct: 510 IPVPLYNLVYH----DCVIQPWMMDRVAGGDDYMLYALLNGG--APYLIRDAAYAGMDGD 563 Query: 517 IQLH 520 + Sbjct: 564 MNAA 567 >4BHW-A nrPDB Length = 578 Score = 34.8 bits (78), Expect = 0.14, Method: Composition-based stats. Identities = 28/165 (16%), Positives = 54/165 (32%), Gaps = 13/165 (7%) Query: 118 DYGKWELYIPPKQNKSVLVPHGSKLKVVITSKSGEILYRISPWAKYVVREGDNVNYDWIH 177 + G+ + + +K+V V G K + V SGE+ P+ + + ++ + Sbjct: 285 ESGEVTVRVVHASDKTVEVKPGMKARFV---DSGEMAESF-PYRTKALFAFEEIDGVDLC 340 Query: 178 WDPEHSYEFKHSRPKKPRSLRI--YESHVGISSHEGKVAS-YKHFTCNVLPRIKGLGYN- 233 + H E+ P + Y V + + Y L +K LGY Sbjct: 341 FFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTT 400 Query: 234 -CIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEE-LQELVDTA 276 I E Y + +E ++++D A Sbjct: 401 GHIWACPPSEGDDYIFHC-HPPDQKIPKPK--RLQEWFKKMLDKA 442 >4ZMT-A nrPDB Length = 232 Score = 34.8 bits (78), Expect = 0.15, Method: Composition-based stats. Identities = 30/153 (19%), Positives = 53/153 (34%), Gaps = 16/153 (10%) Query: 63 EGGIDKFSRGYESFGVHRCADGGLYCKEWAPGA----EGVFLTGDFNGWNPFSYPYKKLD 118 E G F + ++ D ++ PGA EGVF GW + P + + Sbjct: 12 ENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREE 71 Query: 119 YGKWELY----------IPPKQNKSVLVPHGSKLKVVITSKS--GEILYRISPWAKYVVR 166 K+EL+ + N S++V + K T + G +L + P + Sbjct: 72 IAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQV 131 Query: 167 EGDNVNYDWIHWDPEHSYEFKHSRPKKPRSLRI 199 + + ++ +Y PK P L Sbjct: 132 TATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMF 164 >4PZS-A nrPDB Length = 378 Score = 33.6 bits (75), Expect = 0.27, Method: Composition-based stats. Identities = 28/165 (16%), Positives = 54/165 (32%), Gaps = 13/165 (7%) Query: 118 DYGKWELYIPPKQNKSVLVPHGSKLKVVITSKSGEILYRISPWAKYVVREGDNVNYDWIH 177 + G+ + + +K+V V G K + V SGE+ P+ + + ++ + Sbjct: 31 ESGEVTVRVVHASDKTVEVKPGMKARFV---DSGEMAESF-PYRTKALFAFEEIDGVDLC 86 Query: 178 WDPEHSYEFKHSRPKKPRSLRI--YESHVGISSHEGKVAS-YKHFTCNVLPRIKGLGYN- 233 + H E+ P + Y V + + Y L +K LGY Sbjct: 87 FFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTT 146 Query: 234 -CIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEE-LQELVDTA 276 I E Y + +E ++++D A Sbjct: 147 GHIWACPPSEGDDYIFHC-HPPDQKIPKPK--RLQEWFKKMLDKA 188 >5XZC-A nrPDB Length = 619 Score = 33.2 bits (74), Expect = 0.42, Method: Composition-based stats. Identities = 23/127 (18%), Positives = 43/127 (33%), Gaps = 9/127 (7%) Query: 118 DYGKWELYIPPKQNKSVLVPHGSKLKVVITSKSGEILYRISPWAKYVVREGDNVNYDWIH 177 + G+ + + +K+V V G K + V SGE+ P+ + + ++ + Sbjct: 272 ESGEVTVRVVHASDKTVEVKPGMKARFV---DSGEMAESF-PYRTKALFAFEEIDGVDLC 327 Query: 178 WDPEHSYEFKHSRPKKPRSLRI--YESHVGISSHEGKVAS-YKHFTCNVLPRIKGLGYN- 233 + H E+ P + Y V + + Y L +K LGY Sbjct: 328 FFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTT 387 Query: 234 -CIQLMA 239 I Sbjct: 388 GHIWACP 394 >5VTM-X nrPDB Length = 273 Score = 32.9 bits (73), Expect = 0.57, Method: Composition-based stats. Identities = 24/66 (36%), Positives = 31/66 (46%), Gaps = 9/66 (13%) Query: 8 AARPEDYEAALNAALADVPELARLLEIDPYLKPYAVD------FQRRYKQFSQILKNIGE 61 +A PED A LN A VP LA + EIDP VD FQ + F++ L +G Sbjct: 166 SALPED--APLNVNTASVPVLAAMFEIDPGQAENIVDARGREGFQSK-DDFTKHLTQLGS 222 Query: 62 NEGGID 67 G + Sbjct: 223 KTGNVS 228 >5KJ2-A nrPDB Length = 348 Score = 32.9 bits (73), Expect = 0.57, Method: Composition-based stats. Identities = 23/127 (18%), Positives = 43/127 (33%), Gaps = 9/127 (7%) Query: 118 DYGKWELYIPPKQNKSVLVPHGSKLKVVITSKSGEILYRISPWAKYVVREGDNVNYDWIH 177 + G+ + + +K+V V G K + V SGE+ P+ + + ++ + Sbjct: 31 ESGEVTVRVVHASDKTVEVKPGMKARFV---DSGEMAESF-PYRTKALFAFEEIDGVDLC 86 Query: 178 WDPEHSYEFKHSRPKKPRSLRI--YESHVGISSHEGKVAS-YKHFTCNVLPRIKGLGYN- 233 + H E+ P + Y V + + Y L +K LGY Sbjct: 87 FFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTT 146 Query: 234 -CIQLMA 239 I Sbjct: 147 GHIWACP 153 >5I2U-A nrPDB Length = 332 Score = 32.5 bits (72), Expect = 0.60, Method: Composition-based stats. Identities = 15/97 (15%), Positives = 39/97 (40%), Gaps = 5/97 (5%) Query: 246 YASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDG 305 A+ G +I + + + + + ++++A GI V++D HA + F Sbjct: 89 RAAMGLEIEDNYRENPEFA-LQCITPVIESAIENGIYVIIDF---HAHNKYTEEAKTFFA 144 Query: 306 TDSCYFHSGPRGTHDLWDSRLFAYSSWEILRFLLSNI 342 + + P +++W+ + + E+ + I Sbjct: 145 GMAEKYGEYPNVIYEIWNEPDY-FEWEEVKTYSEEVI 180 >3DUG-A nrPDB Length = 408 Score = 32.5 bits (72), Expect = 0.63, Method: Composition-based stats. Identities = 9/19 (47%), Positives = 14/19 (73%) Query: 265 TPEELQELVDTAHSMGIIV 283 T EE++ +VD AH+ G+ V Sbjct: 204 TLEEMKAIVDEAHNHGMKV 222 >3HFQ-A nrPDB Length = 347 Score = 32.1 bits (71), Expect = 0.89, Method: Composition-based stats. Identities = 18/136 (13%), Positives = 41/136 (30%), Gaps = 13/136 (9%) Query: 127 PPKQNKSVLVPHGSKLKVVITSKSGEILYRISPWAKYVVREGDNVNYDWIHWDPEHSYEF 186 P + + + ++ G++ + + E + + P+ Y F Sbjct: 150 PDNRLAVIDLGSDKVYVYNVSDA-GQLSEQS-----VLTMEA-GFGPRHLVFSPDGQYAF 202 Query: 187 KHSRPKKPRSLRIYESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYY 246 + Y++ G + G V + G I+L Y Sbjct: 203 LAGELSSQIASLKYDTQTGAFTQLGIVKTIPA------DYTAHNGAAAIRLSHDGHFLYV 256 Query: 247 ASFGYQITSFFAASSR 262 ++ GY + FA ++ Sbjct: 257 SNRGYNTLAVFAVTAD 272 >3PLN-A nrPDB Length = 424 Score = 31.7 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 24/137 (17%), Positives = 42/137 (30%), Gaps = 11/137 (8%) Query: 369 VGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPALCSPISQGG 428 + GF+ D E G+ + +L L L P I I E + + +G Sbjct: 155 IPVGFTRDIKERLGIDNVIFSPEFLREGRALYDNLHPSRIVIGERSARAERFADLLKEGA 214 Query: 429 GGFDYRLAMAIPDKWIQLLKEFKDEDWNMGDIVYTLTNRRYLEKCIAYAESHDQALVGDK 488 D + E + Y Y + +YAES Q L + Sbjct: 215 I---------KQDIPTLFTDSTEAEAIKLFANTYLALRVAYFNELDSYAES--QGLNSKQ 263 Query: 489 SLAFWLMDAEMYTNMSV 505 + +D + + + Sbjct: 264 IIEGVCLDPRIGNHYNN 280 >6MRE-A nrPDB Length = 420 Score = 31.7 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 34/158 (21%), Positives = 53/158 (33%), Gaps = 18/158 (11%) Query: 264 GTPEELQELVDTAHSMGIIVLLD---VVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHD 320 GT L E++ AH G VL+D V H L+ S + GP G Sbjct: 192 GTENPLAEMITLAHQHGAKVLVDGAQAVMHH--PVDVQALDCDFYVFSGHKLYGPTGIGI 249 Query: 321 LW--DSRLFAYSSWEILRFLLSNI-----RWWLEEYRFDGFRFDGVTSMLYHHHGVGQGF 373 L+ ++ L WE +++ + W + +RF+ T +G G Sbjct: 250 LYVKEALLQEMPPWEGGGSMIATVSLSEGTTWTKAP----WRFEAGTPNTGGI--IGLGA 303 Query: 374 SGDYSEYFGLQVDEDALTYLMLANHLVHTLCPDSITIA 411 + +Y GL + LM PD Sbjct: 304 ALEYVSALGLNNIAEYEQNLMHYALSQLESVPDLTLYG 341 >2OV1-A nrPDB Length = 260 Score = 31.7 bits (70), Expect = 1.2, Method: Composition-based stats. Identities = 21/134 (15%), Positives = 45/134 (33%), Gaps = 28/134 (20%) Query: 166 REGDNVNYDWIHWDPEHSYEF------KHSRPKKPRSLRIYESHVGISSHEGKVASYKHF 219 G + D W + K P + YE+++ E Sbjct: 91 MPGRLMVADPHIWLSPTLVKRQATTIAKELAELDPDNRDQYEANLAAFLAE--------- 141 Query: 220 TCNVLPRI-KGLGYNCIQLMAIMEHA-YYASFGYQITSFF------AASSRYGTPEELQE 271 L R+ + LG +Q + + ++ S+ Y + + + +EL++ Sbjct: 142 ----LERLNQELG-QILQPLPQRKFIVFHPSWAYFARDYNLVQIPIEVEGQEPSAQELKQ 196 Query: 272 LVDTAHSMGIIVLL 285 L+DTA + ++ Sbjct: 197 LIDTAKENNLTMVF 210 >2CKS-A nrPDB Length = 306 Score = 31.3 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 9/37 (24%), Positives = 19/37 (51%), Gaps = 1/37 (2%) Query: 251 YQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDV 287 Y + + R G + + +L+D A + G+ V++D Sbjct: 65 YIQEDGYETNPR-GFTDRMHQLIDMATARGLYVIVDW 100 >3B0H-A nrPDB Length = 588 Score = 31.3 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 15/98 (15%), Positives = 27/98 (27%), Gaps = 1/98 (1%) Query: 344 WWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTYLMLANHLVHTL 403 W ++E +GFR + V M ++ + V Sbjct: 338 WLVDELGVEGFRAEVVKRMPQQKLDRESTEDLVQKQW-ERREYLGVHPQKQEGYSFVGLH 396 Query: 404 CPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPD 441 P A+D+ + L G + IP+ Sbjct: 397 IPVGRVQADDMDELARLADEYGSGELRLTVEQNIIIPN 434 >1PQ4-A nrPDB Length = 291 Score = 31.3 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 13/86 (15%), Positives = 34/86 (39%), Gaps = 9/86 (10%) Query: 208 SHEGKVASYKHFTCNVLPRI-KGLGYNCIQLMAIMEHA-YYASFGYQITSFF------AA 259 + + + L R+ + LG +Q + + ++ S+ Y + Sbjct: 158 DNRDQYEANLAAFLAELERLNQELG-QILQPLPQRKFIVFHPSWAYFARDYNLVQIPIEV 216 Query: 260 SSRYGTPEELQELVDTAHSMGIIVLL 285 + + +EL++L+DTA + ++ Sbjct: 217 EGQEPSAQELKQLIDTAKENNLTMVF 242 >2Y2W-A nrPDB Length = 574 Score = 30.9 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 23/125 (18%), Positives = 35/125 (28%), Gaps = 14/125 (11%) Query: 135 LVPHGSKLKVVITSKSGEILYRISPWAKYVVREGDNVNYDWIHWDPEHSYEFKHS-RPKK 193 + H S+ T SP NV+ P+ S P Sbjct: 1 MTTHNSQYSAETTHPD---KQESSPAPTAAGTTASNVSTTGNATTPDASIALNADATPVA 57 Query: 194 PRSLRIYESHV---------GISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEHA 244 R++ S V GI A F +VL +K LG C++ Sbjct: 58 DVPPRLFGSFVEHLGRCVYGGIYEPSHPTADENGFRQDVLDLVKELGVTCVRY-PGGNFV 116 Query: 245 YYASF 249 ++ Sbjct: 117 SNYNW 121 >5FUC-C nrPDB Length = 231 Score = 30.9 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 16/79 (20%), Positives = 30/79 (37%), Gaps = 1/79 (1%) Query: 489 SLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEW 548 + +F+ + E+ FT + + +Q H +I GL L EFG EW Sbjct: 154 NSSFYRLRFELRYRAERSKTFTTWMVKDLQHHAVIHDAWSGLRHVVQLR-AQEEFGQGEW 212 Query: 549 LDFPRKGNNESYHYARRQF 567 ++ + + +R Sbjct: 213 SEWSPEAMGTPWTESRSPP 231 >4G80-S nrPDB Length = 155 Score = 30.9 bits (68), Expect = 2.0, Method: Composition-based stats. Identities = 15/85 (17%), Positives = 33/85 (38%), Gaps = 11/85 (12%) Query: 281 IIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRLFAYSSWEILRFLLS 340 I++++D+ S++S + SCYF + + F + WE+ L+ Sbjct: 42 ILMIIDLSLPGKSESSQSFYDGMALALSCYFMLDLGLRIFAYGPKNFFTNPWEVADGLII 101 Query: 341 NIRW-----------WLEEYRFDGF 354 + + +++E DG Sbjct: 102 VVTFVVTIFYTVLDEYVQETGADGL 126 >4G7Y-S nrPDB Length = 185 Score = 30.9 bits (68), Expect = 2.0, Method: Composition-based stats. Identities = 15/85 (17%), Positives = 33/85 (38%), Gaps = 11/85 (12%) Query: 281 IIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRLFAYSSWEILRFLLS 340 I++++D+ S++S + SCYF + + F + WE+ L+ Sbjct: 53 ILMIIDLSLPGKSESSQSFYDGMALALSCYFMLDLGLRIFAYGPKNFFTNPWEVADGLII 112 Query: 341 NIRW-----------WLEEYRFDGF 354 + + +++E DG Sbjct: 113 VVTFVVTIFYTVLDEYVQETGADGL 137 >5IHS-A nrPDB Length = 347 Score = 30.9 bits (68), Expect = 2.2, Method: Composition-based stats. Identities = 17/75 (22%), Positives = 36/75 (48%), Gaps = 2/75 (2%) Query: 270 QELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRLFAY 329 E+V+ A + GI V++D HSH ++ + F + + + P +++++ L A Sbjct: 107 MEVVNAAIAKGIYVIIDY-HSHEAQKNPAAAQRFFSEMAKKYGNIPNIIYEVYNEPLQAT 165 Query: 330 S-SWEILRFLLSNIR 343 S + +I + I Sbjct: 166 SWNKDIKPYAEGVIT 180 >1N26-A nrPDB Length = 325 Score = 30.5 bits (67), Expect = 2.4, Method: Composition-based stats. Identities = 16/79 (20%), Positives = 30/79 (37%), Gaps = 1/79 (1%) Query: 489 SLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEW 548 + +F+ + E+ FT + + +Q H +I GL L EFG EW Sbjct: 226 NSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLR-AQEEFGQGEW 284 Query: 549 LDFPRKGNNESYHYARRQF 567 ++ + + +R Sbjct: 285 SEWSPEAMGTPWTESRSPP 303 >4ML9-A nrPDB Length = 286 Score = 30.5 bits (67), Expect = 2.8, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 20/44 (45%), Gaps = 2/44 (4%) Query: 264 GTPEELQELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGTD 307 T E+L+++V AH G+ L+D H G++ + Sbjct: 144 STLEDLKDVVKYAHKYGL--LVDAYIGHPDDLHTFGISARTPEE 185 >1Z0N-A nrPDB Length = 96 Score = 30.2 bits (66), Expect = 3.0, Method: Composition-based stats. Identities = 12/51 (23%), Positives = 21/51 (41%), Gaps = 3/51 (5%) Query: 91 WAPGAEGVFLTGDFNGWNPFSYPYKKLDYG-KWELYIPPKQNKSVLVPHGS 140 W G + V+L+G FN W+ P + L +P +++ G Sbjct: 17 WTGGGKEVYLSGSFNNWS--KLPMTRSQNNFVAILDLPEGEHQYKFFVDGQ 65 >2MAS-A nrPDB Length = 314 Score = 30.2 bits (66), Expect = 3.0, Method: Composition-based stats. Identities = 10/30 (33%), Positives = 17/30 (56%), Gaps = 2/30 (6%) Query: 266 PEELQELVDTAHSMGIIVLLDVVHSHASKN 295 P E + VD H++ + ++D+V SH K Sbjct: 92 PAEFKNKVDERHAVNL--IIDLVMSHEPKT 119 >5H8V-A nrPDB Length = 583 Score = 30.2 bits (66), Expect = 3.3, Method: Composition-based stats. Identities = 27/177 (15%), Positives = 49/177 (27%), Gaps = 28/177 (15%) Query: 240 IMEHAYYASFGYQITSFFAASSRYGT---PEELQELVDTAHSMGIIVL---LDVVHSHAS 293 + + S G + YGT P + + V A + +L + VV Sbjct: 195 VTKARNDNSHGTNFPD--SPEPIYGTQYLPRKFKVAVTAAGDNSVDILTNDIGVVVVSDD 252 Query: 294 KNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRLFAYSSWEILRFLLSNI----------- 342 G N++ G H L D Y E + + + I Sbjct: 253 AGEPIGFNIYVGGGMGRTHRVETTFPRLAD--PLGYVPKEDILYAIKAIVVTQRENGRRD 310 Query: 343 -------RWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDALTY 392 ++ ++ + D FR + ++ Y G Q D + Sbjct: 311 DRKYSRMKYMIDRWGIDRFRAEVEKYYGKKFESFRPLPEWQFNSYLGWQEQGDGKLF 367 >1P9M-C nrPDB Length = 201 Score = 29.8 bits (65), Expect = 3.8, Method: Composition-based stats. Identities = 15/72 (20%), Positives = 28/72 (38%), Gaps = 1/72 (1%) Query: 489 SLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEW 548 + +F+ + E+ FT + + +Q H +I GL L EFG EW Sbjct: 131 NSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLR-AQEEFGQGEW 189 Query: 549 LDFPRKGNNESY 560 ++ + + Sbjct: 190 SEWSPEAMGTPW 201 >4RER-B nrPDB Length = 197 Score = 29.8 bits (65), Expect = 4.0, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 22/50 (44%) Query: 91 WAPGAEGVFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGS 140 W+ G + VF++G FN W+ K + L +P +++ G Sbjct: 8 WSEGGKEVFISGSFNNWSTKIPLIKSHNDFVAILDLPEGEHQYKFFVDGQ 57 >6B2E-B nrPDB Length = 272 Score = 29.8 bits (65), Expect = 4.1, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 22/50 (44%) Query: 91 WAPGAEGVFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGS 140 W+ G + VF++G FN W+ K + L +P +++ G Sbjct: 83 WSEGGKEVFISGSFNNWSTKIPLIKSHNDFVAILDLPEGEHQYKFFVDGQ 132 >4BUB-A nrPDB Length = 498 Score = 29.8 bits (65), Expect = 4.4, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 19/44 (43%) Query: 247 ASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHS 290 GY ++ + E E+V A +G+ V++D HS Sbjct: 305 HQLGYDPKDLASSLETFTGVEGRFEVVRGAKKIGLNVVVDFAHS 348 >5JYL-A nrPDB Length = 101 Score = 29.8 bits (65), Expect = 4.4, Method: Composition-based stats. Identities = 17/67 (25%), Positives = 27/67 (40%), Gaps = 4/67 (5%) Query: 63 EGGIDKFSRGYESFGVHRCADGGLYCKEWAPGA----EGVFLTGDFNGWNPFSYPYKKLD 118 E G F + ++ D ++ PGA EGVF GW + P + + Sbjct: 12 ENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREE 71 Query: 119 YGKWELY 125 K+EL+ Sbjct: 72 IAKYELF 78 >2PQ6-A nrPDB Length = 482 Score = 29.4 bits (64), Expect = 4.9, Method: Composition-based stats. Identities = 14/75 (18%), Positives = 23/75 (30%), Gaps = 1/75 (1%) Query: 259 ASSRYGTPEELQELVDTAHSMGIIV-LLDVVHSHASKNSADGLNMFDGTDSCYFHSGPRG 317 G L +L H G + ++ ++H + G FDG F S P G Sbjct: 15 PYPVQGHINPLFKLAKLLHLRGFHITFVNTEYNHKRLLKSRGPKAFDGFTDFNFESIPDG 74 Query: 318 THDLWDSRLFAYSSW 332 + + Sbjct: 75 LTPMEGDGDVSQDVP 89 >2LU3-A nrPDB Length = 105 Score = 29.4 bits (64), Expect = 4.9, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 22/50 (44%) Query: 91 WAPGAEGVFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGS 140 W+ G + VF++G FN W+ K + L +P +++ G Sbjct: 24 WSEGGKEVFISGSFNNWSTKIPLIKSHNDFVAILDLPEGEHQYKFFVDGQ 73 >2GK1-I nrPDB Length = 440 Score = 29.4 bits (64), Expect = 4.9, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 27/63 (42%), Gaps = 4/63 (6%) Query: 257 FAASSRYGTPEELQELVDTAHSMGIIVLLDV-VHSHASKNSADGLNMFDGTDSCYFHSGP 315 + + T ++++E+++ A GI VL + H + G + CY S P Sbjct: 139 YNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHT---LSWGPGIPGLLTPCYSGSEP 195 Query: 316 RGT 318 GT Sbjct: 196 SGT 198 >2G3M-A nrPDB Length = 693 Score = 29.4 bits (64), Expect = 5.1, Method: Composition-based stats. Identities = 19/157 (12%), Positives = 44/157 (28%), Gaps = 10/157 (6%) Query: 270 QELVDTAHSMGIIVLLDVVHSHASKNSADGLNMFDGT-DSCYFHSGPRGTHDLWDSRLF- 327 ++L+D H + ++ + H + + G C SG +W Sbjct: 233 KKLIDELHKRNVKLIT--IVDHGIRVDQNYSPFLSGMGKFCEIESGELFVGKMWPGTTVY 290 Query: 328 -AYSSWEILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQ-- 384 + + + I WL + DG D + + F Sbjct: 291 PDFFREDTREWWAGLISEWLSQ-GVDGIWLDMNEPTDFSRAIEIRDVLSSLPVQFRDDRL 349 Query: 385 --VDEDALTYLMLANHLVHTLCPDSITIAEDVSGMPA 419 D + + + + H ++ + E ++ Sbjct: 350 VTTFPDNVVHYLRGKRVKHEKVRNAYPLYEAMATFKG 386 >4YEE-A nrPDB Length = 90 Score = 29.4 bits (64), Expect = 5.4, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 22/50 (44%) Query: 91 WAPGAEGVFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGS 140 W+ G + VF++G FN W+ K + L +P +++ G Sbjct: 17 WSEGGKEVFISGSFNNWSTKIPLIKSHNDFVAILDLPEGEHQYKFFVDGQ 66 >2GJX-A nrPDB Length = 507 Score = 29.4 bits (64), Expect = 5.9, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 27/63 (42%), Gaps = 4/63 (6%) Query: 257 FAASSRYGTPEELQELVDTAHSMGIIVLLDV-VHSHASKNSADGLNMFDGTDSCYFHSGP 315 + + T ++++E+++ A GI VL + H + G + CY S P Sbjct: 205 YNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHT---LSWGPGIPGLLTPCYSGSEP 261 Query: 316 RGT 318 GT Sbjct: 262 SGT 264 >5FTT-C nrPDB Length = 383 Score = 29.0 bits (63), Expect = 6.5, Method: Composition-based stats. Identities = 7/51 (13%), Positives = 16/51 (31%), Gaps = 1/51 (1%) Query: 107 WNPFS-YPYKKLDYGKWELYIPPKQNKSVLVPHGSKLKVVITSKSGEILYR 156 W S + G W +Y + N +++ + + I + Sbjct: 236 WGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNPYTLRIEGTWDTAYDK 286 >2O8R-A nrPDB Length = 705 Score = 29.0 bits (63), Expect = 6.6, Method: Composition-based stats. Identities = 17/77 (22%), Positives = 29/77 (37%) Query: 24 DVPELARLLEIDPYLKPYAVDFQRRYKQFSQILKNIGENEGGIDKFSRGYESFGVHRCAD 83 DV L R+L+ DP ++ RY I I + + RGY ++ D Sbjct: 489 DVYRLFRILDGDPEPARFSRLLVARYNMGEAITNLIEREIENVKRGKRGYMLLKMNGLQD 548 Query: 84 GGLYCKEWAPGAEGVFL 100 + + + GV + Sbjct: 549 KNVITQLYRASEAGVEI 565 >4NQQ-A nrPDB Length = 213 Score = 29.0 bits (63), Expect = 8.2, Method: Composition-based stats. Identities = 30/153 (19%), Positives = 53/153 (34%), Gaps = 16/153 (10%) Query: 63 EGGIDKFSRGYESFGVHRCADGGLYCKEWAPGA----EGVFLTGDFNGWNPFSYPYKKLD 118 E G F + ++ ++ PGA EGVF +GW P + Sbjct: 11 ENGKGPFPQRLNQLKSNKDRGTKIFYSITGPGADSPPEGVFTIEKESGWLLLHMPLDREK 70 Query: 119 YGKWELY----------IPPKQNKSVLVP--HGSKLKVVITSKSGEILYRISPWAKYVVR 166 K+ELY + N S++V + +K K + G +L + P + Sbjct: 71 IVKYELYGHAVSENGASVEEPMNISIIVTDQNDNKPKFTQDTFRGSVLEGVMPGTSVMQV 130 Query: 167 EGDNVNYDWIHWDPEHSYEFKHSRPKKPRSLRI 199 + + ++ +Y PK+P L Sbjct: 131 TATDEDDAVNTYNGVVAYSIHSQEPKEPHDLMF 163 >4ZCF-A nrPDB Length = 644 Score = 28.6 bits (62), Expect = 8.8, Method: Composition-based stats. Identities = 22/134 (16%), Positives = 47/134 (35%), Gaps = 23/134 (17%) Query: 449 EFKDEDWNMGDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTP 508 E E ++GD+V+ A H+ +V K+ + E +N+S + Sbjct: 213 EIFGEQNHVGDLVWKNATDNNPSN---IAVEHEYIIVYTKNKEQLIS--EWKSNISDVKN 267 Query: 509 FTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRKGNNESYHYARRQFH 568 + +G E + GNE ++ + R+ +E + R ++ Sbjct: 268 -----------------LLVNIGEEFASKYTGNEL-QEKYTQWFREHRSELWPLDRYKYI 309 Query: 569 LTDDDLLRYKFLNN 582 D + ++N Sbjct: 310 DKDGIYTGSQSVHN 323 >2ARW-A nrPDB Length = 126 Score = 28.6 bits (62), Expect = 9.0, Method: Composition-based stats. Identities = 16/79 (20%), Positives = 30/79 (37%), Gaps = 1/79 (1%) Query: 489 SLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEW 548 + +F+ + E+ FT + + +Q H +I GL L EFG EW Sbjct: 35 NSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLR-AQEEFGQGEW 93 Query: 549 LDFPRKGNNESYHYARRQF 567 ++ + + +R Sbjct: 94 SEWSPEAMGTPWTESRSPP 112 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.123 0.328 Lambda K H 0.267 0.0376 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 27,431,055 Number of Sequences: 36641 Number of extensions: 1138911 Number of successful extensions: 3724 Number of sequences better than 10.0: 168 Number of HSP's better than 10.0 without gapping: 203 Number of HSP's successfully gapped in prelim test: 64 Number of HSP's that attempted gapping in prelim test: 3097 Number of HSP's gapped (non-prelim): 342 length of query: 702 length of database: 10,336,785 effective HSP length: 104 effective length of query: 598 effective length of database: 6,526,121 effective search space: 3902620358 effective search space used: 3902620358 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 62 (28.6 bits)