BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q04048 (859 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5MQ0-T nrPDB 1773 0.0 5GM6-v nrPDB 343 2e-94 6ICZ-I nrPDB 216 3e-56 3JB9-r nrPDB 67 2e-11 5XJC-J nrPDB 41 0.003 5CTQ-A nrPDB 40 0.003 5JPZ-A nrPDB 40 0.005 5JJX-A nrPDB 40 0.006 3JB9-R nrPDB 37 0.029 3VSN-A nrPDB 35 0.12 2OOE-A nrPDB 33 0.39 1VPK-A nrPDB 32 0.83 5NLG-A nrPDB 32 1.0 6AHD-N nrPDB 32 1.1 5C9S-B nrPDB 32 1.2 2OND-A nrPDB 31 2.0 6G70-A nrPDB 31 2.4 5LMX-C nrPDB 30 3.1 6F44-C nrPDB 30 3.5 4XRU-C nrPDB 29 7.1 4PDX-A nrPDB 29 7.6 5GMK-d nrPDB 29 8.8 5BQN-A nrPDB 29 9.9 >5MQ0-T nrPDB Length = 877 Score = 1773 bits (4591), Expect = 0.0, Method: Compositional matrix adjust. Identities = 859/859 (100%), Positives = 859/859 (100%) Query: 1 MSAYIAMKGVITNVDENIRNDEDVAFEYEIQKTPQNILTWKRYIEYWKEEGRTDKQIRWL 60 MSAYIAMKGVITNVDENIRNDEDVAFEYEIQKTPQNILTWKRYIEYWKEEGRTDKQIRWL Sbjct: 1 MSAYIAMKGVITNVDENIRNDEDVAFEYEIQKTPQNILTWKRYIEYWKEEGRTDKQIRWL 60 Query: 61 YERFCSQFVTDTSIWEDYIRWESTKEVVETSRIFWLFQRCLKSCVRDCDRICLSYLELAI 120 YERFCSQFVTDTSIWEDYIRWESTKEVVETSRIFWLFQRCLKSCVRDCDRICLSYLELAI Sbjct: 61 YERFCSQFVTDTSIWEDYIRWESTKEVVETSRIFWLFQRCLKSCVRDCDRICLSYLELAI 120 Query: 121 EQYDLAMIRHALASSLMKMEREMHRKVWDPVIKFVEEKVLPLTQLDSTQEDEEESTDEAE 180 EQYDLAMIRHALASSLMKMEREMHRKVWDPVIKFVEEKVLPLTQLDSTQEDEEESTDEAE Sbjct: 121 EQYDLAMIRHALASSLMKMEREMHRKVWDPVIKFVEEKVLPLTQLDSTQEDEEESTDEAE 180 Query: 181 LINVLLVKGFTKGGFISEEISENGSRGDIWSSHILERYLKVAPQQKRNESLATLALTRDN 240 LINVLLVKGFTKGGFISEEISENGSRGDIWSSHILERYLKVAPQQKRNESLATLALTRDN Sbjct: 181 LINVLLVKGFTKGGFISEEISENGSRGDIWSSHILERYLKVAPQQKRNESLATLALTRDN 240 Query: 241 ITIKSVYEKYLPQDENSGKYLPSSELPFELNFNYLASLEKLGLDNQYEEFMRQMNGIYPD 300 ITIKSVYEKYLPQDENSGKYLPSSELPFELNFNYLASLEKLGLDNQYEEFMRQMNGIYPD Sbjct: 241 ITIKSVYEKYLPQDENSGKYLPSSELPFELNFNYLASLEKLGLDNQYEEFMRQMNGIYPD 300 Query: 301 KWLFLILSLAKYYISRGRLDSCGDLLKKSLQQTLRYSDFDRIYNFYLLFEQECSQFILGK 360 KWLFLILSLAKYYISRGRLDSCGDLLKKSLQQTLRYSDFDRIYNFYLLFEQECSQFILGK Sbjct: 301 KWLFLILSLAKYYISRGRLDSCGDLLKKSLQQTLRYSDFDRIYNFYLLFEQECSQFILGK 360 Query: 361 LKENDSKFFNQKDWTEKLQAHMATFESLINLYDIYLNDVALRQDSNLVETWMKRVSLQKS 420 LKENDSKFFNQKDWTEKLQAHMATFESLINLYDIYLNDVALRQDSNLVETWMKRVSLQKS Sbjct: 361 LKENDSKFFNQKDWTEKLQAHMATFESLINLYDIYLNDVALRQDSNLVETWMKRVSLQKS 420 Query: 421 AAEKCNVYSEAILKIDPRKVGTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLKVPYPY 480 AAEKCNVYSEAILKIDPRKVGTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLKVPYPY Sbjct: 421 AAEKCNVYSEAILKIDPRKVGTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLKVPYPY 480 Query: 481 IEDLEEIYLNWADRELDKEGVERAFSILEDALHVPTNPEILLEKYKNGHRKIPAQTVLFN 540 IEDLEEIYLNWADRELDKEGVERAFSILEDALHVPTNPEILLEKYKNGHRKIPAQTVLFN Sbjct: 481 IEDLEEIYLNWADRELDKEGVERAFSILEDALHVPTNPEILLEKYKNGHRKIPAQTVLFN 540 Query: 541 SLRIWSKYIDYLEAYCPKDANSSDKIFNKTKMAYNTVIDLRLITPAMAENFALFLQNHYE 600 SLRIWSKYIDYLEAYCPKDANSSDKIFNKTKMAYNTVIDLRLITPAMAENFALFLQNHYE Sbjct: 541 SLRIWSKYIDYLEAYCPKDANSSDKIFNKTKMAYNTVIDLRLITPAMAENFALFLQNHYE 600 Query: 601 VMESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGI 660 VMESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGI Sbjct: 601 VMESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGI 660 Query: 661 DCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTL 720 DCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTL Sbjct: 661 DCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTL 720 Query: 721 GPSVTRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYGAKLLPPSRNTEL 780 GPSVTRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYGAKLLPPSRNTEL Sbjct: 721 GPSVTRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYGAKLLPPSRNTEL 780 Query: 781 WDSFEIFELKHGDKETYKDMLKMKKVLESNMLIDSASVSHEEGNINFVAAATSHAPNSHT 840 WDSFEIFELKHGDKETYKDMLKMKKVLESNMLIDSASVSHEEGNINFVAAATSHAPNSHT Sbjct: 781 WDSFEIFELKHGDKETYKDMLKMKKVLESNMLIDSASVSHEEGNINFVAAATSHAPNSHT 840 Query: 841 LTQSTSSYSINPDEIELDI 859 LTQSTSSYSINPDEIELDI Sbjct: 841 LTQSTSSYSINPDEIELDI 859 >5GM6-v nrPDB Length = 859 Score = 343 bits (881), Expect = 2e-94, Method: Compositional matrix adjust. Identities = 166/166 (100%), Positives = 166/166 (100%) Query: 569 KTKMAYNTVIDLRLITPAMAENFALFLQNHYEVMESFQVYEKTIPLFPPEIQYELWIEYL 628 KTKMAYNTVIDLRLITPAMAENFALFLQNHYEVMESFQVYEKTIPLFPPEIQYELWIEYL Sbjct: 569 KTKMAYNTVIDLRLITPAMAENFALFLQNHYEVMESFQVYEKTIPLFPPEIQYELWIEYL 628 Query: 629 EVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILR 688 EVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILR Sbjct: 629 EVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILR 688 Query: 689 RGAVIGTVSVSTHLESRLQLWRMCISKAESTLGPSVTRELYQECIQ 734 RGAVIGTVSVSTHLESRLQLWRMCISKAESTLGPSVTRELYQECIQ Sbjct: 689 RGAVIGTVSVSTHLESRLQLWRMCISKAESTLGPSVTRELYQECIQ 734 >6ICZ-I nrPDB Length = 855 Score = 216 bits (550), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 153/549 (27%), Positives = 269/549 (48%), Gaps = 44/549 (8%) Query: 298 YPDKWLFLILSLAKYYISRGRLDSCGDLLKKSLQQTLRYSDFDRIYNFYLLFEQECSQFI 357 + D+ L SLA YYI G + D+ +++++ + DF ++++ Y FE+ I Sbjct: 251 FTDQLGKLWCSLADYYIRSGHFEKARDVYEEAIRTVMTVRDFTQVFDSYAQFEES---MI 307 Query: 358 LGKLKENDSKFFNQKDWTEKLQAHMATFESLINLYDIYLNDVALRQDSNLVETWMKRVSL 417 K+ E S+ +++ L+ +A FE LI+ + LN V LRQ+ + V W KRV+L Sbjct: 308 AAKM-ETASELGREEEDDVDLELRLARFEQLISRRPLLLNSVLLRQNPHHVHEWHKRVAL 366 Query: 418 -QKSAAEKCNVYSEAILKIDPRKV-GTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLK 475 Q E N Y+EA+ +DP K G P + LW ++ Y + + AR + ++ K Sbjct: 367 HQGRPREIINTYTEAVQTVDPFKATGKPHT---LWVAFAKFYEDNGQLDDARVILEKATK 423 Query: 476 VPYPYIEDLEEIYLNWADRELDKEGVERAFSILEDALHVPTNPEILLEKYKNGHRKIPAQ 535 V + ++DL ++ + EL E + A +L A +P +Y +G P Q Sbjct: 424 VNFKQVDDLASVWCQCGELELRHENYDEALRLLRKATALPAR----RAEYFDGSE--PVQ 477 Query: 536 TVLFNSLRIWSKYIDYLEAYCPKDANSSDKIFNKTKMAYNTVIDLRLITPAMAENFALFL 595 ++ SL++WS D E S F TK Y+ ++DLR+ TP + N+A+FL Sbjct: 478 NRVYKSLKVWSMLADLEE---------SLGTFQSTKAVYDRILDLRIATPQIVINYAMFL 528 Query: 596 QNHYEVMESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNL 655 + H ESF+ YE+ I LF ++W YL + + E R LFE+AL Sbjct: 529 EEHKYFEESFKAYERGISLFKWPNVSDIWSTYLTKFIA-RYGGRKLERARDLFEQALDG- 586 Query: 656 CSNGIDCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISK 715 C KT+++ Y+ EE GL ++ + R + + + ++ + I + Sbjct: 587 CPPKY-AKTLYLLYAQLEEEW-GLARHAMAVYERA------TRAVEPAQQYDMFNIYIKR 638 Query: 716 AESTLGPSVTRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYGAKLLPPS 775 A G + TR +YQ+ I++L + A E ++F+D E +GE RAR I ++ +++ P Sbjct: 639 AAEIYGVTHTRGIYQKAIEVLSDEHAREMCLRFADMECKLGEIDRARAIYSFCSQICDPR 698 Query: 776 RNTELWDSFEIFELKHGDKETYKDMLKMKKVLESNMLIDSASVSHEEGNINFVAAATSHA 835 W +++ FE++HG+++T K+ML++++ +++ +NF+A+ Sbjct: 699 TTGAFWQTWKDFEVRHGNEDTIKEMLRIRRSVQATY----------NTQVNFMASQMLKV 748 Query: 836 PNSHTLTQS 844 S T T S Sbjct: 749 SGSATGTVS 757 Score = 35.4 bits (80), Expect = 0.11, Method: Compositional matrix adjust. Identities = 29/141 (20%), Positives = 55/141 (39%), Gaps = 7/141 (4%) Query: 30 IQKTPQNILTWKRYIEYWKEEGRTDKQIRWLYERFCSQFVTDTSIWEDYI--RWESTKEV 87 I + ++ W RYIE+ ++G ++ LYER +W Y+ R K Sbjct: 28 IMRNQFSVKCWLRYIEF--KQGAPKPRLNQLYERALKLLPCSYKLWYRYLKARRAQVKHR 85 Query: 88 VETSRIFWLFQRCLKSC---VRDCDRICLSYLELAIEQYDLAMIRHALASSLMKMEREMH 144 T + C + + R+ L Y + ++Q + R +L + H Sbjct: 86 CVTDPAYEDVNNCHERAFVFMHKMPRLWLDYCQFLMDQGRVTHTRRTFDRALRALPITQH 145 Query: 145 RKVWDPVIKFVEEKVLPLTQL 165 ++W ++F+ LP T + Sbjct: 146 SRIWPLYLRFLRSHPLPETAV 166 >3JB9-r nrPDB Length = 790 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 49/166 (29%), Positives = 86/166 (51%), Gaps = 12/166 (7%) Query: 570 TKMAYNTVIDLRLITPAMAENFALFLQNHYEVMESFQVYEKTIPLFPPEIQYELWIEYL- 628 T+ Y+ V +L++ TP + N+A L+ + +SF++YE+ + LF + +ELW YL Sbjct: 499 TRKLYDRVFELKIATPQVVVNYANLLEENAYFEDSFKIYERGVALFSYPVAFELWNLYLT 558 Query: 629 EVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILR 688 + +Q + + E R LFE+AL+ C K+I++ Y+ FEE+ G +SI IL Sbjct: 559 KFVKRYQGTHM--ERTRDLFEQALEG-CPPEF-SKSIYLLYADFEEKF-GKAKRSISILE 613 Query: 689 RGAVIGTVSVSTHLESRLQLWRMCISKAESTLGPSVTRELYQECIQ 734 + A RL ++ + + K G TR +Y++ I+ Sbjct: 614 KAA------DKVKTADRLAIYNVLLVKVALNYGVLATRTVYEKAIE 653 Score = 28.9 bits (63), Expect = 9.3, Method: Compositional matrix adjust. Identities = 21/90 (23%), Positives = 43/90 (47%), Gaps = 9/90 (10%) Query: 683 SIEILRRGAVIGTVSVSTHLESRLQLWRMCISK-AESTLGPSV--TRELYQECIQILPNS 739 S +I RG + + V+ +LW + ++K + G + TR+L+++ ++ P Sbjct: 533 SFKIYERGVALFSYPVA------FELWNLYLTKFVKRYQGTHMERTRDLFEQALEGCPPE 586 Query: 740 KAVEFVIKFSDFESSIGETIRAREILAYGA 769 + + ++DFE G+ R+ IL A Sbjct: 587 FSKSIYLLYADFEEKFGKAKRSISILEKAA 616 >5XJC-J nrPDB Length = 848 Score = 40.8 bits (94), Expect = 0.003, Method: Compositional matrix adjust. Identities = 52/232 (22%), Positives = 90/232 (38%), Gaps = 65/232 (28%) Query: 606 QVYEKTIPLFPPEIQYELWIEYL----EVATSHQLSSLSPEHIRFLFEKALKNLCSNGID 661 +VYE+ I PP + W Y+ A +L + PE R +++ +L+ + Sbjct: 512 EVYERAIANVPPIQEKRHWKRYIYLWINYALYEELEAKDPERTRQVYQASLELIPHKKFT 571 Query: 662 CKTIFIAYSVFEERISGLISKSIEILRR--GAVIGTV------SVSTHLESRLQLWRMCI 713 ++I Y+ FE R K++ + RR G IG V LE +L+ + C Sbjct: 572 FAKMWILYAQFEIR-----QKNLSLARRALGTSIGKCPKNKLFKVYIELELQLREFDRC- 625 Query: 714 SKAESTLGPSVTRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYG----- 768 R+LY++ ++ P + IKF++ E+ +G+ RAR I Sbjct: 626 ------------RKLYEKFLEFGPEN--CTSWIKFAELETILGDIDRARAIYELAISQPR 671 Query: 769 ----------------------------AKLLPPSRNTELWDSFEIFELKHG 792 +LL +++ ++W SF FEL G Sbjct: 672 LDMPEVLWKSYIDFEIEQEETERTRNLYRRLLQRTQHVKVWISFAQFELSSG 723 Score = 37.4 bits (85), Expect = 0.028, Method: Compositional matrix adjust. Identities = 72/410 (17%), Positives = 155/410 (37%), Gaps = 73/410 (17%) Query: 401 LRQDSNLVETWMKRVSLQKSAAE--KCNVYSEAILKIDPRKVGTPGSFGRLWCSYGDLYW 458 +R++ ++ W+K ++S E + E L +D R + LW Y ++ Sbjct: 235 IRKNRTVISNWIKYAQWEESLKEIQRARSIYERALDVDYRNIT-------LWLKYAEMEM 287 Query: 459 RSNAISTARELWTQSLKVPYPYIEDLEEIYLNWADRELDKEGVERAFSILEDALHVPTNP 518 ++ ++ AR +W ++ I L + W ++ +E+ L Sbjct: 288 KNRQVNHARNIWDRA-------ITTLPRVNQFWY-----------KYTYMEEMLGNVAGA 329 Query: 519 EILLEKYKNGHRKIPAQTVLFNSLRIWSKYIDYLEAYCPKDANSSDKIFNKTKMAYNTVI 578 + E++ + A W YI++ Y K ++ + Y + Sbjct: 330 RQVFERWMEWQPEEQA----------WHSYINFELRY---------KEVDRARTIYERFV 370 Query: 579 DLRLITPAMAE--NFALFLQNHYEVMESFQVYEKTIPLFPPE-IQYELWIEYLEVATSHQ 635 L+ P + +A F + H + +VYE+ + F E + L++ + + + + Sbjct: 371 ---LVHPDVKNWIKYARFEEKHAYFAHARKVYERAVEFFGDEHMDEHLYVAFAKFEENQK 427 Query: 636 LSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERISGL--ISKSIEILRRGAVI 693 E +R +++ AL + D + +F Y++FE++ I I RR Sbjct: 428 ----EFERVRVIYKYALDRISKQ--DAQELFKNYTIFEKKFGDRRGIEDIIVSKRRFQYE 481 Query: 694 GTVSVSTHLESRLQLWRMCISKAESTLGPSVTRELYQECIQILPN-------SKAVEFVI 746 V + H W + ES RE+Y+ I +P + + I Sbjct: 482 EEVKANPH---NYDAWFDYLRLVESDAEAEAVREVYERAIANVPPIQEKRHWKRYIYLWI 538 Query: 747 KFSDFES-SIGETIRAREILAYGAKLLPPSRNT--ELWDSFEIFELKHGD 793 ++ +E + R R++ +L+P + T ++W + FE++ + Sbjct: 539 NYALYEELEAKDPERTRQVYQASLELIPHKKFTFAKMWILYAQFEIRQKN 588 Score = 35.8 bits (81), Expect = 0.077, Method: Compositional matrix adjust. Identities = 21/85 (24%), Positives = 41/85 (48%), Gaps = 1/85 (1%) Query: 725 TRELYQECIQILPNSKAVEFV-IKFSDFESSIGETIRAREILAYGAKLLPPSRNTELWDS 783 R++Y+ ++ + E + + F+ FE + E R R I Y + EL+ + Sbjct: 395 ARKVYERAVEFFGDEHMDEHLYVAFAKFEENQKEFERVRVIYKYALDRISKQDAQELFKN 454 Query: 784 FEIFELKHGDKETYKDMLKMKKVLE 808 + IFE K GD+ +D++ K+ + Sbjct: 455 YTIFEKKFGDRRGIEDIIVSKRRFQ 479 >5CTQ-A nrPDB Length = 561 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 31/102 (30%), Positives = 47/102 (46%), Gaps = 10/102 (9%) Query: 609 EKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIA 668 +K +FP + ELW+E+L S L EH+ LFEKA+K+ C I++ Sbjct: 86 QKMSEIFP--LTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKDYI-----CPNIWLE 138 Query: 669 YSVFEERISGLISK-SIEILRRGAVIGTVSVSTHLESRLQLW 709 Y + + G+ K +E +R SV H+ L LW Sbjct: 139 YGQYS--VGGIGQKGGLEKVRSVFERALSSVGLHMTKGLALW 178 >5JPZ-A nrPDB Length = 509 Score = 40.0 bits (92), Expect = 0.005, Method: Compositional matrix adjust. Identities = 31/102 (30%), Positives = 47/102 (46%), Gaps = 10/102 (9%) Query: 609 EKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIA 668 +K +FP + ELW+E+L S L EH+ LFEKA+K+ C I++ Sbjct: 71 QKMSEIFP--LTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKDYI-----CPNIWLE 123 Query: 669 YSVFEERISGLISK-SIEILRRGAVIGTVSVSTHLESRLQLW 709 Y + + G+ K +E +R SV H+ L LW Sbjct: 124 YGQYS--VGGIGQKGGLEKVRSVFERALSSVGLHMTKGLALW 163 >5JJX-A nrPDB Length = 314 Score = 39.7 bits (91), Expect = 0.006, Method: Compositional matrix adjust. Identities = 31/102 (30%), Positives = 47/102 (46%), Gaps = 10/102 (9%) Query: 609 EKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIA 668 +K +FP + ELW+E+L S L EH+ LFEKA+K+ C I++ Sbjct: 57 QKMSEIFP--LTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKDYI-----CPNIWLE 109 Query: 669 YSVFEERISGLISK-SIEILRRGAVIGTVSVSTHLESRLQLW 709 Y + + G+ K +E +R SV H+ L LW Sbjct: 110 YGQYS--VGGIGQKGGLEKVRSVFERALSSVGLHMTKGLALW 149 >3JB9-R nrPDB Length = 674 Score = 37.4 bits (85), Expect = 0.029, Method: Compositional matrix adjust. Identities = 45/189 (23%), Positives = 74/189 (39%), Gaps = 30/189 (15%) Query: 623 LWIEYLEVATSHQLSSLSPEHIRFLFEKA----------------LKNLCSNGIDCKTIF 666 LW++Y+E ++ + + H R LF++A ++ + N C+ +F Sbjct: 106 LWLKYIEC----EMKNRNINHARNLFDRAVTQLPRVDKLWYKYVYMEEMLGNITGCRQVF 161 Query: 667 IAYSVFEERISGLISKSIEILRR------GAVIGTVSVSTHLESRLQLWRMCISKAESTL 720 + +E + +S I + RR I V H E + W E Sbjct: 162 ERWLKWEPDENCWMS-YIRMERRYHENERARGIYERFVVVHPE--VTNWLRWARFEEECG 218 Query: 721 GPSVTRELYQECIQILPNSKAVE-FVIKFSDFESSIGETIRAREILAYGAKLLPPSRNTE 779 + R++Y I L E F I F+ FE E RAR I Y +P S++ E Sbjct: 219 NAANVRQVYLAAIDALGQEFLNERFFIAFAKFEIRQKEYERARTIFKYAIDFMPRSKSME 278 Query: 780 LWDSFEIFE 788 L+ + FE Sbjct: 279 LYKEYTHFE 287 >3VSN-A nrPDB Length = 659 Score = 35.4 bits (80), Expect = 0.12, Method: Compositional matrix adjust. Identities = 22/67 (32%), Positives = 35/67 (52%), Gaps = 7/67 (10%) Query: 523 EKYKNGHRKIPAQTVLFNSLRIWSKYIDY------LEAYCPKDANSSDKIFNKTKMAYNT 576 EK N +R TV F++L W+ D+ L YC + N+SD ++ ++AYN Sbjct: 51 EKVVNPNRNWNDNTV-FDNLSPWTSVPDFGTVCHTLIGYCVRYNNTSDTLYQNPELAYNL 109 Query: 577 VIDLRLI 583 + LR+I Sbjct: 110 INGLRII 116 >2OOE-A nrPDB Length = 530 Score = 33.5 bits (75), Expect = 0.39, Method: Compositional matrix adjust. Identities = 29/113 (25%), Positives = 49/113 (43%), Gaps = 16/113 (14%) Query: 27 EYEIQKTPQNILTWKRYIEYWKEEGRTDKQIRWLYERFCSQFVTDTSIWEDYIRWESTKE 86 E ++++ P ++ W I + + + + R YER +QF + W+ YI E+ + Sbjct: 3 EKKLEENPYDLDAWSILIR--EAQNQPIDKARKTYERLVAQFPSSGRFWKLYI--EAEIK 58 Query: 87 VVETSRIFWLFQRCLK------------SCVRDCDRICLSYLELAIEQYDLAM 127 ++ LFQRCL S VR+ SY E + YD A+ Sbjct: 59 AKNYDKVEKLFQRCLMKVLHIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFAL 111 Score = 31.6 bits (70), Expect = 1.6, Method: Compositional matrix adjust. Identities = 18/55 (32%), Positives = 28/55 (50%), Gaps = 6/55 (10%) Query: 743 EFVIKFSDFESSIGETIRAR----EILAYGAKLLPPSRNTELWDSFEIFELKHGD 793 E+V+ + D+ S + E R +L G+ LPP ++ E+W F FE GD Sbjct: 426 EYVLAYIDYLSHLNEDNNTRVLFERVLTSGS--LPPEKSGEIWARFLAFESNIGD 478 >1VPK-A nrPDB Length = 378 Score = 32.3 bits (72), Expect = 0.83, Method: Compositional matrix adjust. Identities = 23/95 (24%), Positives = 45/95 (47%), Gaps = 10/95 (10%) Query: 209 IWSSHILERYLKVAPQQKRNESLATLALTRDNITIKSVYEKY----LPQDENSGKYLPSS 264 + ++++ +KV P + + L+L D + I S + +P DE S Sbjct: 81 VVPGDVIQKMVKVLPDE-----ITELSLEGDALVISSGSTVFRITTMPADEFPEITPAES 135 Query: 265 ELPFELNFNYLASL-EKLGLDNQYEEFMRQMNGIY 298 + FE++ + L + EK+ +EFMR +NG++ Sbjct: 136 GITFEVDTSLLEEMVEKVIFAAAKDEFMRNLNGVF 170 >5NLG-A nrPDB Length = 314 Score = 32.0 bits (71), Expect = 1.0, Method: Compositional matrix adjust. Identities = 21/77 (27%), Positives = 36/77 (46%), Gaps = 2/77 (2%) Query: 725 TRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYGAKLLPPSRNTELWDSF 784 R + ++ LP +E V KF+ E + G+ R R + G P R +LW+ + Sbjct: 194 ARTILGNALKALPKRNHIEVVRKFAQLEFAKGDPERGRSLFE-GLVADAPKR-IDLWNVY 251 Query: 785 EIFELKHGDKETYKDML 801 E+K DK+ +D+ Sbjct: 252 VDQEVKAKDKKKVEDLF 268 >6AHD-N nrPDB Length = 941 Score = 32.0 bits (71), Expect = 1.1, Method: Compositional matrix adjust. Identities = 39/133 (29%), Positives = 63/133 (47%), Gaps = 18/133 (13%) Query: 446 FGRLWCSYGDLYWRSNAISTARELWTQSLKVPYPYIEDLEEIYLNWADRELDKEGVERAF 505 F +LW G + + + ARE + Q LK P+ L +L + E + RA Sbjct: 708 FPKLWMMKGQIEEQKEMMEKAREAYNQGLK-KCPHSTPL---WLLLSRLEEKIGQLTRAR 763 Query: 506 SILEDA-LHVPTNPEILLE----KYKNGHRKIPAQTVLFNSLR-------IWSKYIDYLE 553 +ILE + L P NP + LE +Y+ G + I A T++ +L+ +WS+ I +LE Sbjct: 764 AILEKSRLKNPKNPGLWLESVRLEYRAGLKNI-ANTLMAKALQECPNSGILWSEAI-FLE 821 Query: 554 AYCPKDANSSDKI 566 A + S D + Sbjct: 822 ARPQRRTKSVDAL 834 >5C9S-B nrPDB Length = 572 Score = 32.0 bits (71), Expect = 1.2, Method: Compositional matrix adjust. Identities = 21/77 (27%), Positives = 36/77 (46%), Gaps = 2/77 (2%) Query: 725 TRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYGAKLLPPSRNTELWDSF 784 R + ++ LP +E V KF+ E + G+ R R + G P R +LW+ + Sbjct: 444 ARTILGNALKALPKRNHIEVVRKFAQLEFAKGDPERGRSLFE-GLVADAPKR-IDLWNVY 501 Query: 785 EIFELKHGDKETYKDML 801 E+K DK+ +D+ Sbjct: 502 VDQEVKAKDKKKVEDLF 518 >2OND-A nrPDB Length = 308 Score = 31.2 bits (69), Expect = 2.0, Method: Compositional matrix adjust. Identities = 18/55 (32%), Positives = 28/55 (50%), Gaps = 6/55 (10%) Query: 743 EFVIKFSDFESSIGETIRAR----EILAYGAKLLPPSRNTELWDSFEIFELKHGD 793 E+V+ + D+ S + E R +L G+ LPP ++ E+W F FE GD Sbjct: 204 EYVLAYIDYLSHLNEDNNTRVLFERVLTSGS--LPPEKSGEIWARFLAFESNIGD 256 >6G70-A nrPDB Length = 670 Score = 30.8 bits (68), Expect = 2.4, Method: Compositional matrix adjust. Identities = 22/78 (28%), Positives = 37/78 (47%), Gaps = 9/78 (11%) Query: 16 ENIRNDEDVAFEYEIQKTPQNILTWKRYIEYWKE-----EGRTDKQIRWLYERFCSQFVT 70 +NI+ ++V + +Q P ++ W YI + KE + T+ IR +E T Sbjct: 146 DNIKQSDEV-YRRGLQAIPLSVDLWIHYINFLKETLDPGDQETNTTIRGTFEHAVLAAGT 204 Query: 71 D---TSIWEDYIRWESTK 85 D +WE YI WE+ + Sbjct: 205 DFRSDKLWEMYINWENEQ 222 >5LMX-C nrPDB Length = 380 Score = 30.4 bits (67), Expect = 3.1, Method: Compositional matrix adjust. Identities = 32/106 (30%), Positives = 49/106 (46%), Gaps = 21/106 (19%) Query: 134 SSLMKMEREMHRKVWDPVIKFVEEKVLP--LTQLDSTQEDEEESTDEAELINVLLVK--- 188 +S+++ E HR I V KV P LT +DS D+E+ TDE ++ L VK Sbjct: 89 TSVIQDEVLAHR------IGLVPLKVDPDMLTWVDSNLPDDEKFTDENTIVLSLNVKCTR 142 Query: 189 --GFTKGGFISEEISENGSRGDIWSSHILERYLKVAPQQKRNESLA 232 KG +E+ N +H+ R LK PQ +++ + A Sbjct: 143 NPDAPKGSTDPKELYNN--------AHVYARDLKFEPQGRQSTTFA 180 >6F44-C nrPDB Length = 335 Score = 30.4 bits (67), Expect = 3.5, Method: Compositional matrix adjust. Identities = 32/106 (30%), Positives = 49/106 (46%), Gaps = 21/106 (19%) Query: 134 SSLMKMEREMHRKVWDPVIKFVEEKVLP--LTQLDSTQEDEEESTDEAELINVLLVK--- 188 +S+++ E HR I V KV P LT +DS D+E+ TDE ++ L VK Sbjct: 89 TSVIQDEVLAHR------IGLVPLKVDPDMLTWVDSNLPDDEKFTDENTIVLSLNVKCTR 142 Query: 189 --GFTKGGFISEEISENGSRGDIWSSHILERYLKVAPQQKRNESLA 232 KG +E+ N +H+ R LK PQ +++ + A Sbjct: 143 NPDAPKGSTDPKELYNN--------AHVYARDLKFEPQGRQSTTFA 180 >4XRU-C nrPDB Length = 436 Score = 29.3 bits (64), Expect = 7.1, Method: Compositional matrix adjust. Identities = 14/65 (21%), Positives = 32/65 (49%) Query: 353 CSQFILGKLKENDSKFFNQKDWTEKLQAHMATFESLINLYDIYLNDVALRQDSNLVETWM 412 C++F L+E + + Q W E+ +A + T+ I + ++Y N + ++E + Sbjct: 80 CNEFFKELLQEKQTYWSQQIKWLERTRAEVDTYPCTIEVKNLYANSTWYSKGHFMMERYF 139 Query: 413 KRVSL 417 K + + Sbjct: 140 KNIHI 144 >4PDX-A nrPDB Length = 640 Score = 29.3 bits (64), Expect = 7.6, Method: Compositional matrix adjust. Identities = 33/105 (31%), Positives = 45/105 (42%), Gaps = 11/105 (10%) Query: 187 VKGFTKGGFISEEISENGSRGDIWSSHILERYLKVAPQQKR----NESLATLALTRDNI- 241 V+ GF+ E ISEN G+I S L Y + P + N TLA +I Sbjct: 174 VQVIAPAGFMDEAISENVLAGNIMSRRALYSYGLLLPHNAQGNVGNGLGVTLATGDPSII 233 Query: 242 ----TIKSVYEKYLPQD-ENSGKYLPSSELPFELNFNYLASLEKL 281 TI EK + E P SE P E++F Y+ +L+ L Sbjct: 234 APTKTIVRTGEKMIIDGLEFDFLMTPGSEAPAEMHF-YIPALKAL 277 >5GMK-d nrPDB Length = 687 Score = 28.9 bits (63), Expect = 8.8, Method: Compositional matrix adjust. Identities = 38/202 (18%), Positives = 81/202 (40%), Gaps = 29/202 (14%) Query: 591 FALFLQNHYEVMESFQVYEKTIPL---FPPEIQYELWIEYLEVATSHQLSSLSPEHIRFL 647 +A F +++ + ++E+ + + F P LWI Y++ +L H R L Sbjct: 71 YAQFEIEQHDMRRARSIFERALLVDSSFIP-----LWIRYIDA----ELKVKCINHARNL 121 Query: 648 FEKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQ 707 +A+ L ++ Y + EE ++ ++EI+R + LE + Sbjct: 122 MNRAISTLPR----VDKLWYKYLIVEESLN-----NVEIVR-----SLYTKWCSLEPGVN 167 Query: 708 LWRMCISKAESTLGPSVTRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAY 767 W + + RE+Y + + P ++ +K+ FE+ G T R + + Sbjct: 168 AWNSFVDFEIRQKNWNGVREIYSKYVMAHPQ---MQTWLKWVRFENRHGNTEFTRSVYSL 224 Query: 768 GAKLLPPSRNTELWDSFEIFEL 789 + +N ++W E+ +L Sbjct: 225 AIDTVANLQNLQIWSDMEVAKL 246 >5BQN-A nrPDB Length = 885 Score = 28.9 bits (63), Expect = 9.9, Method: Compositional matrix adjust. Identities = 27/87 (31%), Positives = 40/87 (45%), Gaps = 12/87 (13%) Query: 479 PYIED----LEEIYLN-WADRELDKEGVERAFSILEDAL--HVPTNPEI---LLEKYKNG 528 PY+ D +EI+ N E + + FS+ E L VP NPEI LL Sbjct: 469 PYVADKDSISQEIFENKIITDETNVQNYSDKFSLDESILDGQVPINPEIVDPLLPNVNME 528 Query: 529 HRKIPAQTVLFNSLRIWSKYIDYLEAY 555 +P + ++F +KY+DYL +Y Sbjct: 529 PLNLPGEEIVF--YDDITKYVDYLNSY 553 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5MQ0-T nrPDB 1516 0.0 6ICZ-I nrPDB 764 0.0 5GM6-v nrPDB 255 6e-68 3JB9-r nrPDB 209 6e-54 Sequences not found previously or not previously below threshold: 5XJC-J nrPDB 85 1e-16 2OOE-A nrPDB 53 4e-07 6AHD-N nrPDB 52 7e-07 5C9S-B nrPDB 45 1e-04 5NLG-A nrPDB 43 5e-04 5JJX-A nrPDB 42 0.002 5JPZ-A nrPDB 42 0.002 5CTQ-A nrPDB 41 0.002 2OND-A nrPDB 41 0.002 5GMK-d nrPDB 39 0.007 5LJ5-S nrPDB 39 0.007 6G70-A nrPDB 34 0.25 1VPK-A nrPDB 33 0.56 3RM5-A nrPDB 33 0.76 3VSN-A nrPDB 32 0.90 3OPY-A nrPDB 31 2.0 1W6K-A nrPDB 31 2.3 1W3B-A nrPDB 31 2.6 5DGR-A nrPDB 30 4.5 5IC8-A nrPDB 30 4.8 5OQL-E nrPDB 30 5.2 6BMQ-A nrPDB 29 9.4 >5MQ0-T nrPDB Length = 877 Score = 1516 bits (3926), Expect = 0.0, Method: Composition-based stats. Identities = 859/859 (100%), Positives = 859/859 (100%) Query: 1 MSAYIAMKGVITNVDENIRNDEDVAFEYEIQKTPQNILTWKRYIEYWKEEGRTDKQIRWL 60 MSAYIAMKGVITNVDENIRNDEDVAFEYEIQKTPQNILTWKRYIEYWKEEGRTDKQIRWL Sbjct: 1 MSAYIAMKGVITNVDENIRNDEDVAFEYEIQKTPQNILTWKRYIEYWKEEGRTDKQIRWL 60 Query: 61 YERFCSQFVTDTSIWEDYIRWESTKEVVETSRIFWLFQRCLKSCVRDCDRICLSYLELAI 120 YERFCSQFVTDTSIWEDYIRWESTKEVVETSRIFWLFQRCLKSCVRDCDRICLSYLELAI Sbjct: 61 YERFCSQFVTDTSIWEDYIRWESTKEVVETSRIFWLFQRCLKSCVRDCDRICLSYLELAI 120 Query: 121 EQYDLAMIRHALASSLMKMEREMHRKVWDPVIKFVEEKVLPLTQLDSTQEDEEESTDEAE 180 EQYDLAMIRHALASSLMKMEREMHRKVWDPVIKFVEEKVLPLTQLDSTQEDEEESTDEAE Sbjct: 121 EQYDLAMIRHALASSLMKMEREMHRKVWDPVIKFVEEKVLPLTQLDSTQEDEEESTDEAE 180 Query: 181 LINVLLVKGFTKGGFISEEISENGSRGDIWSSHILERYLKVAPQQKRNESLATLALTRDN 240 LINVLLVKGFTKGGFISEEISENGSRGDIWSSHILERYLKVAPQQKRNESLATLALTRDN Sbjct: 181 LINVLLVKGFTKGGFISEEISENGSRGDIWSSHILERYLKVAPQQKRNESLATLALTRDN 240 Query: 241 ITIKSVYEKYLPQDENSGKYLPSSELPFELNFNYLASLEKLGLDNQYEEFMRQMNGIYPD 300 ITIKSVYEKYLPQDENSGKYLPSSELPFELNFNYLASLEKLGLDNQYEEFMRQMNGIYPD Sbjct: 241 ITIKSVYEKYLPQDENSGKYLPSSELPFELNFNYLASLEKLGLDNQYEEFMRQMNGIYPD 300 Query: 301 KWLFLILSLAKYYISRGRLDSCGDLLKKSLQQTLRYSDFDRIYNFYLLFEQECSQFILGK 360 KWLFLILSLAKYYISRGRLDSCGDLLKKSLQQTLRYSDFDRIYNFYLLFEQECSQFILGK Sbjct: 301 KWLFLILSLAKYYISRGRLDSCGDLLKKSLQQTLRYSDFDRIYNFYLLFEQECSQFILGK 360 Query: 361 LKENDSKFFNQKDWTEKLQAHMATFESLINLYDIYLNDVALRQDSNLVETWMKRVSLQKS 420 LKENDSKFFNQKDWTEKLQAHMATFESLINLYDIYLNDVALRQDSNLVETWMKRVSLQKS Sbjct: 361 LKENDSKFFNQKDWTEKLQAHMATFESLINLYDIYLNDVALRQDSNLVETWMKRVSLQKS 420 Query: 421 AAEKCNVYSEAILKIDPRKVGTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLKVPYPY 480 AAEKCNVYSEAILKIDPRKVGTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLKVPYPY Sbjct: 421 AAEKCNVYSEAILKIDPRKVGTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLKVPYPY 480 Query: 481 IEDLEEIYLNWADRELDKEGVERAFSILEDALHVPTNPEILLEKYKNGHRKIPAQTVLFN 540 IEDLEEIYLNWADRELDKEGVERAFSILEDALHVPTNPEILLEKYKNGHRKIPAQTVLFN Sbjct: 481 IEDLEEIYLNWADRELDKEGVERAFSILEDALHVPTNPEILLEKYKNGHRKIPAQTVLFN 540 Query: 541 SLRIWSKYIDYLEAYCPKDANSSDKIFNKTKMAYNTVIDLRLITPAMAENFALFLQNHYE 600 SLRIWSKYIDYLEAYCPKDANSSDKIFNKTKMAYNTVIDLRLITPAMAENFALFLQNHYE Sbjct: 541 SLRIWSKYIDYLEAYCPKDANSSDKIFNKTKMAYNTVIDLRLITPAMAENFALFLQNHYE 600 Query: 601 VMESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGI 660 VMESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGI Sbjct: 601 VMESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGI 660 Query: 661 DCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTL 720 DCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTL Sbjct: 661 DCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTL 720 Query: 721 GPSVTRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYGAKLLPPSRNTEL 780 GPSVTRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYGAKLLPPSRNTEL Sbjct: 721 GPSVTRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYGAKLLPPSRNTEL 780 Query: 781 WDSFEIFELKHGDKETYKDMLKMKKVLESNMLIDSASVSHEEGNINFVAAATSHAPNSHT 840 WDSFEIFELKHGDKETYKDMLKMKKVLESNMLIDSASVSHEEGNINFVAAATSHAPNSHT Sbjct: 781 WDSFEIFELKHGDKETYKDMLKMKKVLESNMLIDSASVSHEEGNINFVAAATSHAPNSHT 840 Query: 841 LTQSTSSYSINPDEIELDI 859 LTQSTSSYSINPDEIELDI Sbjct: 841 LTQSTSSYSINPDEIELDI 859 >6ICZ-I nrPDB Length = 855 Score = 764 bits (1973), Expect = 0.0, Method: Composition-based stats. Identities = 153/549 (27%), Positives = 269/549 (48%), Gaps = 44/549 (8%) Query: 298 YPDKWLFLILSLAKYYISRGRLDSCGDLLKKSLQQTLRYSDFDRIYNFYLLFEQECSQFI 357 + D+ L SLA YYI G + D+ +++++ + DF ++++ Y FE+ I Sbjct: 251 FTDQLGKLWCSLADYYIRSGHFEKARDVYEEAIRTVMTVRDFTQVFDSYAQFEES---MI 307 Query: 358 LGKLKENDSKFFNQKDWTEKLQAHMATFESLINLYDIYLNDVALRQDSNLVETWMKRVSL 417 K+ E S+ +++ L+ +A FE LI+ + LN V LRQ+ + V W KRV+L Sbjct: 308 AAKM-ETASELGREEEDDVDLELRLARFEQLISRRPLLLNSVLLRQNPHHVHEWHKRVAL 366 Query: 418 -QKSAAEKCNVYSEAILKIDPRKV-GTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLK 475 Q E N Y+EA+ +DP K G P + LW ++ Y + + AR + ++ K Sbjct: 367 HQGRPREIINTYTEAVQTVDPFKATGKPHT---LWVAFAKFYEDNGQLDDARVILEKATK 423 Query: 476 VPYPYIEDLEEIYLNWADRELDKEGVERAFSILEDALHVPTNPEILLEKYKNGHRKIPAQ 535 V + ++DL ++ + EL E + A +L A +P +Y +G P Q Sbjct: 424 VNFKQVDDLASVWCQCGELELRHENYDEALRLLRKATALPAR----RAEYFDGSE--PVQ 477 Query: 536 TVLFNSLRIWSKYIDYLEAYCPKDANSSDKIFNKTKMAYNTVIDLRLITPAMAENFALFL 595 ++ SL++WS D E S F TK Y+ ++DLR+ TP + N+A+FL Sbjct: 478 NRVYKSLKVWSMLADLEE---------SLGTFQSTKAVYDRILDLRIATPQIVINYAMFL 528 Query: 596 QNHYEVMESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNL 655 + H ESF+ YE+ I LF ++W YL + + E R LFE+AL Sbjct: 529 EEHKYFEESFKAYERGISLFKWPNVSDIWSTYLTKFIA-RYGGRKLERARDLFEQALDG- 586 Query: 656 CSNGIDCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISK 715 C KT+++ Y+ EE GL ++ + R + + + ++ + I + Sbjct: 587 CPPKY-AKTLYLLYAQLEEEW-GLARHAMAVYERA------TRAVEPAQQYDMFNIYIKR 638 Query: 716 AESTLGPSVTRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYGAKLLPPS 775 A G + TR +YQ+ I++L + A E ++F+D E +GE RAR I ++ +++ P Sbjct: 639 AAEIYGVTHTRGIYQKAIEVLSDEHAREMCLRFADMECKLGEIDRARAIYSFCSQICDPR 698 Query: 776 RNTELWDSFEIFELKHGDKETYKDMLKMKKVLESNMLIDSASVSHEEGNINFVAAATSHA 835 W +++ FE++HG+++T K+ML++++ +++ +NF+A+ Sbjct: 699 TTGAFWQTWKDFEVRHGNEDTIKEMLRIRRSVQATY----------NTQVNFMASQMLKV 748 Query: 836 PNSHTLTQS 844 S T T S Sbjct: 749 SGSATGTVS 757 Score = 54.0 bits (128), Expect = 3e-07, Method: Composition-based stats. Identities = 95/573 (16%), Positives = 196/573 (34%), Gaps = 107/573 (18%) Query: 297 IYPDKWLFLILSLAKYYISRGRLDSCGDLLKKSLQQTLRYSDFDRIYNFYLLFEQECSQF 356 ++ K L L ++ + +GR+ ++L+ L + RI+ YL F + Sbjct: 104 VFMHKMPRLWLDYCQFLMDQGRVTHTRRTFDRALR-ALPITQHSRIWPLYLRFLRSHP-- 160 Query: 357 ILGKLKENDSKFFNQ---------KDWTEKLQAHMATFESLINLYDIYLND--VALRQDS 405 L E + + + +++ E L++ + +ND + Sbjct: 161 ----LPETAVRGYRRFLKLSPESAEEYIEYLKSS-DRLDEAAQRLATVVNDERFVSKAGK 215 Query: 406 NLVETWMKRVSLQKSAAEKCNVYSEAILKIDPRKVGTPGSF----GRLWCSYGDLYWRSN 461 + + W + L +K L +D G F G+LWCS D Y RS Sbjct: 216 SNYQLWHELCDLISQNPDKVQS-----LNVDAIIRGGLTRFTDQLGKLWCSLADYYIRSG 270 Query: 462 AISTARELWTQSLKVPYPYIEDLEEIYLNWA-------------------------DREL 496 AR+++ ++++ + D +++ ++A D EL Sbjct: 271 HFEKARDVYEEAIRTVMT-VRDFTQVFDSYAQFEESMIAAKMETASELGREEEDDVDLEL 329 Query: 497 DKEGVERAFS---ILEDALHVPTNPEILLEKYKNG--HRKIP----------AQTV---- 537 E+ S +L +++ + NP + E +K H+ P QTV Sbjct: 330 RLARFEQLISRRPLLLNSVLLRQNPHHVHEWHKRVALHQGRPREIINTYTEAVQTVDPFK 389 Query: 538 -LFNSLRIWSKYIDYLEAYCPKDANSSDKIFNKTKMAYNTVIDLRLITPAMAENFALFLQ 596 +W + + E D ++ + TK+ + V DL + E Sbjct: 390 ATGKPHTLWVAFAKFYEDNGQLD-DARVILEKATKVNFKQVDDLASVWCQCGE----LEL 444 Query: 597 NHYEVMESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLC 656 H E+ ++ K L + + + E + SL + E++L Sbjct: 445 RHENYDEALRLLRKATAL---PARRAEYFDGSEPVQNRVYKSLKVWSMLADLEESLGTFQ 501 Query: 657 SNG----------IDCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRL 706 S I I I Y++F E +S + RG + + Sbjct: 502 STKAVYDRILDLRIATPQIVINYAMFLEE-HKYFEESFKAYERGISLFKWPNVS------ 554 Query: 707 QLWRMCISKAESTLG---PSVTRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRARE 763 +W ++K + G R+L+++ + P A + ++ E G A Sbjct: 555 DIWSTYLTKFIARYGGRKLERARDLFEQALDGCPPKYAKTLYLLYAQLEEEWGLARHAMA 614 Query: 764 ILAYGAKLLPPSRNTELWDSF-----EIFELKH 791 + + + P++ ++++ + EI+ + H Sbjct: 615 VYERATRAVEPAQQYDMFNIYIKRAAEIYGVTH 647 Score = 45.9 bits (107), Expect = 8e-05, Method: Composition-based stats. Identities = 132/741 (17%), Positives = 246/741 (33%), Gaps = 163/741 (21%) Query: 30 IQKTPQNILTWKRYIEYWKEEGRTDKQIRWLYERFCSQFVTDTSIWEDYI--RWESTKEV 87 I + ++ W RYIE+ ++G ++ LYER +W Y+ R K Sbjct: 28 IMRNQFSVKCWLRYIEF--KQGAPKPRLNQLYERALKLLPCSYKLWYRYLKARRAQVKHR 85 Query: 88 VETSRIFWLFQRCLKSC---VRDCDRICLSYLELAIEQYDLAMIRHALASSLMKMEREMH 144 T + C + + R+ L Y + ++Q + R +L + H Sbjct: 86 CVTDPAYEDVNNCHERAFVFMHKMPRLWLDYCQFLMDQGRVTHTRRTFDRALRALPITQH 145 Query: 145 RKVWDPVIKFVEEKVLPLTQ-------LDSTQEDEEE------STDEAELINVLLVKGFT 191 ++W ++F+ LP T L + E EE S+D + L Sbjct: 146 SRIWPLYLRFLRSHPLPETAVRGYRRFLKLSPESAEEYIEYLKSSDRLDEAAQRLATVVN 205 Query: 192 KGGFISEE--------------ISENGSR---------------------GDIWSSHILE 216 F+S+ IS+N + G +W S + + Sbjct: 206 DERFVSKAGKSNYQLWHELCDLISQNPDKVQSLNVDAIIRGGLTRFTDQLGKLWCS-LAD 264 Query: 217 RYLKVAPQQKR----NESLATLALTRDNITIKSVYEKYLPQDEN--SGKYLPSSELPFE- 269 Y++ +K E++ T+ RD V++ Y +E+ + K +SEL E Sbjct: 265 YYIRSGHFEKARDVYEEAIRTVMTVRD---FTQVFDSYAQFEESMIAAKMETASELGREE 321 Query: 270 ----------LNFNYLASLEKLGLDNQYEEFMRQMNGIYPDKWLFLILSLAKYYISRGRL 319 F L S L L++ +RQ N + +W + + +GR Sbjct: 322 EDDVDLELRLARFEQLISRRPLLLNSV---LLRQ-NPHHVHEWHKRVA------LHQGRP 371 Query: 320 DSCGDLLKKSLQQTLRYSDFDR---IYNFYLLFEQECSQFILGK-LKENDSKF-FNQKDW 374 + +++Q + + ++ + F ++ Q + + E +K F Q D Sbjct: 372 REIINTYTEAVQTVDPFKATGKPHTLWVAFAKFYEDNGQLDDARVILEKATKVNFKQVDD 431 Query: 375 TEKLQAHMATFESLINLYDIYLNDVALRQDSNLVETWMKRVSLQKSAAEKCNVYSEAILK 434 + E YD L LR K +L AE + SE + Sbjct: 432 LASVWCQCGELELRHENYDEALR--LLR----------KATALPARRAEYFDG-SEPVQN 478 Query: 435 IDPRKVGTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLKVPYPYIEDLE----EIYLN 490 ++W DL QS K Y I DL +I +N Sbjct: 479 -------RVYKSLKVWSMLADLEESLGTF--------QSTKAVYDRILDLRIATPQIVIN 523 Query: 491 WADRELDKEGVERAFSILEDALHVPTNPEILLEKYKNGHRKIPAQTVLFNSLRIWSKYID 550 +A + + E +F E + + P + IWS Y+ Sbjct: 524 YAMFLEEHKYFEESFKAYERGISLFKWPNVS---------------------DIWSTYL- 561 Query: 551 YLEAYCPKDANSSDKIFNKTKMAYNTVIDLRLITPAMAEN----FALFLQNHYEVMESFQ 606 A + + + + +D P A+ +A + + Sbjct: 562 -----TKFIARYGGRKLERARDLFEQALDG--CPPKYAKTLYLLYAQLEEEWGLARHAMA 614 Query: 607 VYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIF 666 VYE+ P QY+++ Y++ A H R +++KA++ L + + Sbjct: 615 VYERATRAVEPAQQYDMFNIYIKRAAEIYG----VTHTRGIYQKAIEVLSDE--HAREMC 668 Query: 667 IAYSVFEERISGLISKSIEIL 687 + ++ E ++ G I ++ I Sbjct: 669 LRFADMECKL-GEIDRARAIY 688 Score = 41.2 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 48/277 (17%), Positives = 96/277 (34%), Gaps = 28/277 (10%) Query: 524 KYKNGHRKIPAQTVLFN--------SLRIWSKYIDYLEAYCPKDANSSDKIFNKTKMAYN 575 ++K G K P L+ S ++W +Y+ A K +D + + Sbjct: 43 EFKQGAPK-PRLNQLYERALKLLPCSYKLWYRYLKARRAQV-KHRCVTDPAYEDVNNCHE 100 Query: 576 TVIDLRLITPAMAENFALFLQNHYEVMESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQ 635 P + ++ FL + V + + +++ + P +W YL SH Sbjct: 101 RAFVFMHKMPRLWLDYCQFLMDQGRVTHTRRTFDRALRALPITQHSRIWPLYLRFLRSHP 160 Query: 636 LSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILRRGAVIGT 695 L PE + + LK S +I Y +R+ + + V Sbjct: 161 L----PETAVRGYRRFLK--LSPE--SAEEYIEYLKSSDRLDEAAQRLATV-----VNDE 207 Query: 696 VSVSTHLESRLQLWRM---CISKAESTLGPSVTRELYQECIQILPNSKAVEFVIKFSDFE 752 VS +S QLW IS+ + + + + + + +D+ Sbjct: 208 RFVSKAGKSNYQLWHELCDLISQNPDKVQSLNVDAIIRGGLTRFTDQLGKLWC-SLADYY 266 Query: 753 SSIGETIRAREILAYGAK-LLPPSRNTELWDSFEIFE 788 G +AR++ + ++ T+++DS+ FE Sbjct: 267 IRSGHFEKARDVYEEAIRTVMTVRDFTQVFDSYAQFE 303 >5GM6-v nrPDB Length = 859 Score = 255 bits (651), Expect = 6e-68, Method: Composition-based stats. Identities = 166/166 (100%), Positives = 166/166 (100%) Query: 569 KTKMAYNTVIDLRLITPAMAENFALFLQNHYEVMESFQVYEKTIPLFPPEIQYELWIEYL 628 KTKMAYNTVIDLRLITPAMAENFALFLQNHYEVMESFQVYEKTIPLFPPEIQYELWIEYL Sbjct: 569 KTKMAYNTVIDLRLITPAMAENFALFLQNHYEVMESFQVYEKTIPLFPPEIQYELWIEYL 628 Query: 629 EVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILR 688 EVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILR Sbjct: 629 EVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILR 688 Query: 689 RGAVIGTVSVSTHLESRLQLWRMCISKAESTLGPSVTRELYQECIQ 734 RGAVIGTVSVSTHLESRLQLWRMCISKAESTLGPSVTRELYQECIQ Sbjct: 689 RGAVIGTVSVSTHLESRLQLWRMCISKAESTLGPSVTRELYQECIQ 734 >3JB9-r nrPDB Length = 790 Score = 209 bits (531), Expect = 6e-54, Method: Composition-based stats. Identities = 49/167 (29%), Positives = 86/167 (51%), Gaps = 12/167 (7%) Query: 569 KTKMAYNTVIDLRLITPAMAENFALFLQNHYEVMESFQVYEKTIPLFPPEIQYELWIEYL 628 T+ Y+ V +L++ TP + N+A L+ + +SF++YE+ + LF + +ELW YL Sbjct: 498 TTRKLYDRVFELKIATPQVVVNYANLLEENAYFEDSFKIYERGVALFSYPVAFELWNLYL 557 Query: 629 -EVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEIL 687 + +Q + + E R LFE+AL+ C K+I++ Y+ FEE+ G +SI IL Sbjct: 558 TKFVKRYQGTHM--ERTRDLFEQALEG-CPPEF-SKSIYLLYADFEEKF-GKAKRSISIL 612 Query: 688 RRGAVIGTVSVSTHLESRLQLWRMCISKAESTLGPSVTRELYQECIQ 734 + A RL ++ + + K G TR +Y++ I+ Sbjct: 613 EKAA------DKVKTADRLAIYNVLLVKVALNYGVLATRTVYEKAIE 653 Score = 46.6 bits (109), Expect = 4e-05, Method: Composition-based stats. Identities = 24/125 (19%), Positives = 53/125 (42%), Gaps = 14/125 (11%) Query: 644 IRFLFEKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLE 703 R L+++ + I + + Y+ E + S +I RG + + V+ Sbjct: 499 TRKLYDRVFE----LKIATPQVVVNYANLLEE-NAYFEDSFKIYERGVALFSYPVA---- 549 Query: 704 SRLQLWRMCISKAESTLGPSV---TRELYQECIQILPNSKAVEFVIKFSDFESSIGETIR 760 +LW + ++K + TR+L+++ ++ P + + ++DFE G+ R Sbjct: 550 --FELWNLYLTKFVKRYQGTHMERTRDLFEQALEGCPPEFSKSIYLLYADFEEKFGKAKR 607 Query: 761 AREIL 765 + IL Sbjct: 608 SISIL 612 >5XJC-J nrPDB Length = 848 Score = 85.2 bits (209), Expect = 1e-16, Method: Composition-based stats. Identities = 67/383 (17%), Positives = 157/383 (40%), Gaps = 44/383 (11%) Query: 450 WCSYGDLYWRSNAISTARELWTQSLKVPYPYIEDLEEIYLNWADRELDKEGVERAFSILE 509 W SY + R + AR ++ + + V +P +++ ++ +A E A + E Sbjct: 346 WHSYINFELRYKEVDRARTIYERFVLV-HPDVKN----WIKYARFEEKHAYFAHARKVYE 400 Query: 510 DAL------HVPTNPEILLEKYKNGHRKIPAQTVLFN----------SLRIWSKYIDYLE 553 A+ H+ + + K++ ++ V++ + ++ Y + + Sbjct: 401 RAVEFFGDEHMDEHLYVAFAKFEENQKEFERVRVIYKYALDRISKQDAQELFKNYTIFEK 460 Query: 554 AYCPKDANSSDKIFNKTKMAYNTVIDLRLITPAMAENFALFLQNHYEVMESFQVYEKTIP 613 + + D I +K + Y + ++ +++ E +VYE+ I Sbjct: 461 KFGDRRG-IEDIIVSKRRFQYEEEVKANPHNYDAWFDYLRLVESDAEAEAVREVYERAIA 519 Query: 614 LFPPEIQYELWIEYLEVATSH----QLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAY 669 PP + W Y+ + ++ +L + PE R +++ +L+ + ++I Y Sbjct: 520 NVPPIQEKRHWKRYIYLWINYALYEELEAKDPERTRQVYQASLELIPHKKFTFAKMWILY 579 Query: 670 SVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTLGPSVTRELY 729 + FE R K++ + RR + S + +L+++ I R+LY Sbjct: 580 AQFEIR-----QKNLSLARRA-----LGTSIGKCPKNKLFKVYIELELQLREFDRCRKLY 629 Query: 730 QECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYGAKLLPPSRNTE--LWDSFEIF 787 ++ ++ P + IKF++ E+ +G+ RAR I + P + LW S+ F Sbjct: 630 EKFLEFGPENCTS--WIKFAELETILGDIDRARAIYELA--ISQPRLDMPEVLWKSYIDF 685 Query: 788 ELKHGDKETYKDMLKMKKVLESN 810 E++ + E +++ +++L+ Sbjct: 686 EIEQEETERTRNLY--RRLLQRT 706 Score = 72.1 bits (175), Expect = 9e-13, Method: Composition-based stats. Identities = 59/317 (18%), Positives = 115/317 (36%), Gaps = 33/317 (10%) Query: 495 ELDKEGVERAFSILEDALHVPTNPEILLEKYKNGHRKIPAQTVLFNSLRI--WSKYIDYL 552 +L +E ER +L E L YK RK + N I W KY + Sbjct: 193 QLLREAKERELELLPPPPQQKITDEEELNDYKLRKRKTFEDNIRKNRTVISNWIKYAQWE 252 Query: 553 EAYCPKDANSSDKIFNKTKMAYNTVIDLRLITPAMAENFALFLQNHYEVMESFQVYEKTI 612 E S K + + Y +D+ + +A + +V + ++++ I Sbjct: 253 E---------SLKEIQRARSIYERALDVDYRNITLWLKYAEMEMKNRQVNHARNIWDRAI 303 Query: 613 PLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVF 672 P Q+ Y+E + R +FE+ ++ + + +Y F Sbjct: 304 TTLPRVNQFWYKYTYMEEMLGNVAG------ARQVFERWMEWQ-----PEEQAWHSYINF 352 Query: 673 EERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTLGPSVTRELYQEC 732 E R + ++ I R ++ + +R + + R++Y+ Sbjct: 353 ELRYK-EVDRARTIYERFVLVHPDVKNWIKYARFEEKHAYFA---------HARKVYERA 402 Query: 733 IQILPNSKAVE-FVIKFSDFESSIGETIRAREILAYGAKLLPPSRNTELWDSFEIFELKH 791 ++ + E + F+ FE + E R R I Y + EL+ ++ IFE K Sbjct: 403 VEFFGDEHMDEHLYVAFAKFEENQKEFERVRVIYKYALDRISKQDAQELFKNYTIFEKKF 462 Query: 792 GDKETYKDMLKMKKVLE 808 GD+ +D++ K+ + Sbjct: 463 GDRRGIEDIIVSKRRFQ 479 Score = 50.5 bits (119), Expect = 3e-06, Method: Composition-based stats. Identities = 62/421 (14%), Positives = 133/421 (31%), Gaps = 64/421 (15%) Query: 306 ILSLAKYYISRGRLDSCGDLLKKSLQQTLRYSDFDRIYNFYLLFEQECSQFI-LGKLKEN 364 S + + +D + ++ + ++ + Y FE++ + F K+ E Sbjct: 346 WHSYINFELRYKEVDRARTIYERFVLVHPDVKNWIK----YARFEEKHAYFAHARKVYER 401 Query: 365 DSKFFNQKDWTEKLQAHMATFES---LINLYDIYLNDVALRQDSNLVETWMKRVSL---- 417 +FF + E L A FE + R + K ++ Sbjct: 402 AVEFFGDEHMDEHLYVAFAKFEENQKEFERVRVIYKYALDRISKQDAQELFKNYTIFEKK 461 Query: 418 --QKSAAEKCNVYSEAILKIDPRKVGTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLK 475 + E V + K P ++ W Y L RE++ +++ Sbjct: 462 FGDRRGIEDIIVSKRRFQYEEEVKA-NPHNYDA-WFDYLRLVESDAEAEAVREVYERAI- 518 Query: 476 VPYPYIEDLEEIYLNWADRELDKEGVERAFSILEDALHVPTNPEILLEKYKNGHRKIPAQ 535 P I++ + + + ++ E LE +PE + Y+ IP + Sbjct: 519 ANVPPIQE-KRHWKRYIYLWINYALYEE----LE-----AKDPERTRQVYQASLELIPHK 568 Query: 536 TVLFNSLRIWSKYIDYL----------------EAYCPKDA--------NSSDKIFNKTK 571 F ++W Y + CPK+ + F++ + Sbjct: 569 KFTFA--KMWILYAQFEIRQKNLSLARRALGTSIGKCPKNKLFKVYIELELQLREFDRCR 626 Query: 572 MAYNTVIDLRLITPAMAENFALFLQNHYEVMESFQVYEKTIPLFPPEIQYELWIEYLEVA 631 Y ++ FA ++ + +YE I ++ LW Y++ Sbjct: 627 KLYEKFLEFGPENCTSWIKFAELETILGDIDRARAIYELAISQPRLDMPEVLWKSYIDFE 686 Query: 632 TSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFE--ERISGLISKSIEILRR 689 + + E R L+ + L+ ++I+++ FE G ++K +I Sbjct: 687 IEQEET----ERTRNLYRRLLQ-----RTQHVKVWISFAQFELSSGKEGSLTKCRQIYEE 737 Query: 690 G 690 Sbjct: 738 A 738 Score = 34.7 bits (78), Expect = 0.18, Method: Composition-based stats. Identities = 96/516 (18%), Positives = 186/516 (36%), Gaps = 72/516 (13%) Query: 26 FEYEIQKTPQNILTWKRYIEYWKEEGRTDKQIRWLYERFCSQFVTDTSIWEDYIRWESTK 85 FE I+K I W +Y + W+E + ++ R +YER + ++W Y E Sbjct: 231 FEDNIRKNRTVISNWIKYAQ-WEESLKEIQRARSIYERALDVDYRNITLWLKYAEMEMKN 289 Query: 86 EVVETSRIFWLFQRCLKSCVRDCDRICLSYLELAIEQYDLAMIRHALASSLMKMEREMHR 145 V +R W R + + R ++ Y + ++A R ME + Sbjct: 290 RQVNHARNIW--DRAITTLPR-VNQFWYKYTYMEEMLGNVAGARQVFERW---MEWQPEE 343 Query: 146 KVWDPVIKFVEEKVLPLTQLDSTQEDEEESTDEAELINVLLVKGFTKGGFISEEISENGS 205 + W I F +L + D + E ++ VK + K E+ + Sbjct: 344 QAWHSYINF---------ELRYKEVDRARTIYERFVLVHPDVKNWIKYARFEEKHAYFAH 394 Query: 206 RGDIWS------------SHILERYLKVAPQQKRNESLATLALTRDNITIKSVYEKYLPQ 253 ++ H+ + K QK E R + K ++ Q Sbjct: 395 ARKVYERAVEFFGDEHMDEHLYVAFAKFEENQKEFE--------RVRVIYKYALDRISKQ 446 Query: 254 DENSGKYLPSSELPFELNFNYLASLEKLGLDN---QYEEFMRQMNGIYPDKWLFLILSLA 310 D + L + FE F +E + + QYEE ++ Y D W F L L Sbjct: 447 D---AQELFKNYTIFEKKFGDRRGIEDIIVSKRRFQYEEEVKANPHNY-DAW-FDYLRLV 501 Query: 311 KYYISRGRLDSCGDLLKKS------LQQTLRYSDFDRIYNFYLLFE--QECSQFILGKLK 362 + S ++ ++ +++ +Q+ + + ++ Y L+E + ++ Sbjct: 502 E---SDAEAEAVREVYERAIANVPPIQEKRHWKRYIYLWINYALYEELEAKDPERTRQVY 558 Query: 363 ENDSKFFNQKDWT-EKLQAHMATFESLINLYDIYLNDVAL-----RQDSNLVETWMKRVS 416 + + K +T K+ A FE I ++ L AL + N + + Sbjct: 559 QASLELIPHKKFTFAKMWILYAQFE--IRQKNLSLARRALGTSIGKCPKNKLFKVYIELE 616 Query: 417 LQKSAAEKCNVYSEAILKIDPRKVGTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLKV 476 LQ ++C E L+ P + W + +L I AR ++ L + Sbjct: 617 LQLREFDRCRKLYEKFLEFGPENCTS-------WIKFAELETILGDIDRARAIYE--LAI 667 Query: 477 PYPYIEDLEEIYLNWADRELDKEGVERAFSILEDAL 512 P ++ E ++ ++ D E+++E ER ++ L Sbjct: 668 SQPRLDMPEVLWKSYIDFEIEQEETERTRNLYRRLL 703 >2OOE-A nrPDB Length = 530 Score = 53.2 bits (126), Expect = 4e-07, Method: Composition-based stats. Identities = 73/433 (16%), Positives = 153/433 (35%), Gaps = 56/433 (12%) Query: 407 LVETWMKRVSLQKSAAEKCNVYSEAILKIDPR---KVGTPGSFGRLWCSYGDL------- 456 ++ W +S + K Y E + + K+G ++W Y + Sbjct: 78 HIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQIWVDYINFLKGVEAV 137 Query: 457 --YWRSNAISTARELWTQSLKVPYPYIEDLEEIYLNWAD---RELDKEGVERAFSILEDA 511 Y + I+ R ++ + P IE L Y + + L K+ +E +A Sbjct: 138 GSYAENQRITAVRRVYQRGCVNPMINIEQLWRDYNKYEEGINIHLAKKMIEDRSRDYMNA 197 Query: 512 LHVPTNPEILLEKYKNGHRKIPAQTVLFNSLRI--WSKYIDYLEAYCPKDANSSDKIFNK 569 V E +++ +P Q + ++ W KYI + ++ + + + I + Sbjct: 198 RRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVDMWKKYIQWEKSNPLRTEDQTL-ITKR 256 Query: 570 TKMAYNTVIDLRLITPAMAENFALFLQNHYEV--------------MESFQVYEKTIPLF 615 AY + + P + A +L+ ++ E+ +YE+ I Sbjct: 257 VMFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTL 316 Query: 616 PPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEER 675 + + Y A ++ S + E + ++ + L ID ++I Y F R Sbjct: 317 LKKNM----LLYFAYA-DYEESRMKYEKVHSIYNRLL---AIEDIDPTLVYIQYMKFARR 368 Query: 676 ISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTLGPSVTRELYQECIQI 735 G+ S + I ++ E + ++ A S + + + ++ Sbjct: 369 AEGIKSGRM-IFKKAR-----------EDARTRHHVYVTAALMEYYCSKDKSVAFKIFEL 416 Query: 736 LPNSKA--VEFVIKFSDFESSIGETIRAREILA--YGAKLLPPSRNTELWDSFEIFELKH 791 E+V+ + D+ S + E R + + LPP ++ E+W F FE Sbjct: 417 GLKKYGDIPEYVLAYIDYLSHLNEDNNTRVLFERVLTSGSLPPEKSGEIWARFLAFESNI 476 Query: 792 GDKETYKDMLKMK 804 GD + + K + Sbjct: 477 GDLASILKVEKRR 489 Score = 35.9 bits (81), Expect = 0.086, Method: Composition-based stats. Identities = 29/113 (25%), Positives = 49/113 (43%), Gaps = 16/113 (14%) Query: 27 EYEIQKTPQNILTWKRYIEYWKEEGRTDKQIRWLYERFCSQFVTDTSIWEDYIRWESTKE 86 E ++++ P ++ W I + + + + R YER +QF + W+ YI E+ + Sbjct: 3 EKKLEENPYDLDAWSILIR--EAQNQPIDKARKTYERLVAQFPSSGRFWKLYI--EAEIK 58 Query: 87 VVETSRIFWLFQRCLK------------SCVRDCDRICLSYLELAIEQYDLAM 127 ++ LFQRCL S VR+ SY E + YD A+ Sbjct: 59 AKNYDKVEKLFQRCLMKVLHIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFAL 111 >6AHD-N nrPDB Length = 941 Score = 52.4 bits (124), Expect = 7e-07, Method: Composition-based stats. Identities = 82/451 (18%), Positives = 155/451 (34%), Gaps = 68/451 (15%) Query: 409 ETWMKRVSLQKSAAEK--CNVYSEAILKIDPRKVGTPGSFGRLWCSYGDLYWRSNAISTA 466 E W++ A C A++ I + + W D NA+ A Sbjct: 504 EQWIQDAEECDRAGSVATCQAVMRAVIGIGIEEEDRKHT----WMEDADSCVAHNALECA 559 Query: 467 RELWTQSLKVPYPYIEDLEEIYLNWADRELDKEGVERAFSILEDALHVPTNPEIL----- 521 R ++ +L+V +P + ++L A E + E ++L+ A+ E+L Sbjct: 560 RAIYAYALQV-FP---SKKSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGA 615 Query: 522 LEKYKNGHRKIPAQTVLF--------NSLRIWSKYIDYLEAYCPKDANSSDKIFNKTKMA 573 K+ G +PA + NS IW + + ++ Sbjct: 616 KSKWLAG--DVPAARSILALAFQANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAP 673 Query: 574 YNTVIDLRLITPAMAENFALFLQNHYEVMESFQVYEKTIPLFPPEIQYELWIEYLEVATS 633 V + + +N E+ + YE FP +LW+ ++ Sbjct: 674 TARVFMKSVKLEWVQDN---IRAAQDLCEEALRHYED----FP-----KLWMMKGQIEEQ 721 Query: 634 HQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILRRGAV- 692 ++ E R + + LK C +++ S EE+I G ++++ IL + + Sbjct: 722 KEM----MEKAREAYNQGLK-KCP---HSTPLWLLLSRLEEKI-GQLTRARAILEKSRLK 772 Query: 693 ----IGTVSVSTHLESRLQLWRM---CISKAES---TLGPSVTRELYQEC--------IQ 734 G S LE R L + ++KA G + ++ E + Sbjct: 773 NPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVD 832 Query: 735 ILPN-SKAVEFVIKFSDFESSIGETIRAREILAYGAKLLPPSRNTELWDSFEIFELKHGD 793 L ++ + S + +ARE K+ S + W F FEL+HG Sbjct: 833 ALKKCEHDPHVLLAVAKLFWSQRKITKAREWFHRTVKI--DSDLGDAWAFFYKFELQHGT 890 Query: 794 KETYKDMLKMKKVLESNMLIDSASVSHEEGN 824 +E +++ K + E +VS + N Sbjct: 891 EEQQEEVRKRCESAEPRHGELWCAVSKDIAN 921 Score = 31.2 bits (69), Expect = 1.9, Method: Composition-based stats. Identities = 23/117 (19%), Positives = 47/117 (40%), Gaps = 11/117 (9%) Query: 710 RMCISKAESTLGPSVTRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYGA 769 R+ I AE + + ++ ++ +PNS ++ + E AR +L+ Sbjct: 374 RIYIRAAELETDIRAKKRVLRKALEHVPNS------VRLWKAAVELEEPEDARIMLSRAV 427 Query: 770 KLLPPSRNTELWDSFEIFELKHGDKETYKDMLKMKKVLESNMLIDSASVSHEEGNIN 826 + P + ELW + E + K + K ++ + ++ I + EE N N Sbjct: 428 ECCP--TSVELWLALARLETY---ENARKVLNKARENIPTDRHIWITAAKLEEANGN 479 >5C9S-B nrPDB Length = 572 Score = 45.5 bits (106), Expect = 1e-04, Method: Composition-based stats. Identities = 44/230 (19%), Positives = 82/230 (35%), Gaps = 42/230 (18%) Query: 603 ESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDC 662 ES +E+ L +W+ Y+ + QL E R L E+ALK + Sbjct: 302 ESVADFER--LLIGNPNSSVVWMNYM----AFQLQLSEIEKARELAERALKTINFREEAE 355 Query: 663 K-TIFIAYSVFE---------ERISGLISKSIEIL----------------RRGAVIGTV 696 K I+IA E E + + ++ + A + Sbjct: 356 KLNIWIAMLNLENTFGTEETLEEVFSRACQYMDSYTIHTKLLGIYEISEKFDKAAELFKA 415 Query: 697 SVSTHLESRLQLW----RMCISKAESTLGPSVTRELYQECIQILPNSKAVEFVIKFSDFE 752 + ++ +W IS E R + ++ LP +E V KF+ E Sbjct: 416 TAKKFGGEKVSIWVSWGDFLISHNEE----QEARTILGNALKALPKRNHIEVVRKFAQLE 471 Query: 753 SSIGETIRAREILAYGAKLLPPSRNTELWDSFEIFELKHGDKETYKDMLK 802 + G+ R R + + + + +LW+ + E+K DK+ +D+ + Sbjct: 472 FAKGDPERGRSL--FEGLVADAPKRIDLWNVYVDQEVKAKDKKKVEDLFE 519 Score = 44.3 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 45/236 (19%), Positives = 88/236 (37%), Gaps = 27/236 (11%) Query: 378 LQAHMATFESLINLYDIYLNDVALRQDSNLVETWMKRVSLQ---KSAAEKCNVYSEAILK 434 Q ++ E L + L + R+++ + W+ ++L+ + V+S A Sbjct: 327 FQLQLSEIEKARELAERALKTINFREEAEKLNIWIAMLNLENTFGTEETLEEVFSRACQY 386 Query: 435 IDPRKVGTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLKVPYPYIEDLEEIYLNWADR 494 +D + T +Y S A EL+ + K + + I+++W D Sbjct: 387 MDSYTIHT---------KLLGIYEISEKFDKAAELFKATAK---KFGGEKVSIWVSWGDF 434 Query: 495 ELDKEGVERAFSILEDAL-HVPTNPEILLEKYK---NGHRKIPAQTV-LFNSLRIWS-KY 548 + + A +IL +AL +P I + + + P + LF L + K Sbjct: 435 LISHNEEQEARTILGNALKALPKRNHIEVVRKFAQLEFAKGDPERGRSLFEGLVADAPKR 494 Query: 549 IDYLEAYCPKDANSSDKIFNKTKMAYNTVIDLRLITPAMAENFALFLQNHYEVMES 604 ID Y ++ + DK K + + +I ++ F +LQ ES Sbjct: 495 IDLWNVYVDQEVKAKDK--KKVEDLFERIITKKITRKQAKFFFNKWLQ----FEES 544 Score = 30.8 bits (68), Expect = 2.4, Method: Composition-based stats. Identities = 35/206 (16%), Positives = 73/206 (35%), Gaps = 41/206 (19%) Query: 305 LILSLAKYYISRGRLDSCGDLLKKSLQQTLRYSDFDRIYNFYLLFEQECSQF-ILGKLKE 363 + ++ + + ++ +L +++L+ F +E + I + Sbjct: 320 VWMNYMAFQLQLSEIEKARELAERALKTI--------------NFREEAEKLNIWIAMLN 365 Query: 364 NDSKFFNQKDWTEKLQAHMATFESLINLYDIYLNDVALRQDSNLVETWMKRVSLQKSAAE 423 ++ F ++ T E + + Y++ T ++ +E Sbjct: 366 LENTFGTEE-----------TLEEVFSRACQYMDS----------YTIHTKLLGIYEISE 404 Query: 424 KCNVYSEAILKIDPRKVGTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLKVPYPYIED 483 K + +E + K +K G G +W S+GD N AR + +LK P Sbjct: 405 KFDKAAE-LFKATAKKFG--GEKVSIWVSWGDFLISHNEEQEARTILGNALKA-LPKRNH 460 Query: 484 LEEIYLNWADRELDKEGVERAFSILE 509 +E + +A E K ER S+ E Sbjct: 461 IEVVR-KFAQLEFAKGDPERGRSLFE 485 Score = 30.8 bits (68), Expect = 2.9, Method: Composition-based stats. Identities = 30/164 (18%), Positives = 65/164 (39%), Gaps = 15/164 (9%) Query: 639 LSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSV 698 +PE + FE+ L N +++ Y F+ ++S I K+ E+ R Sbjct: 299 RAPESVAD-FERLLIGN-PN---SSVVWMNYMAFQLQLS-EIEKARELAERALKTINFR- 351 Query: 699 STHLESRLQLWRMCISKAESTLGPSVT-RELYQECIQILPNSKAVEFVIKFSDFESSIGE 757 +L +W + + E+T G T E++ Q + + ++ + Sbjct: 352 --EEAEKLNIW-IAMLNLENTFGTEETLEEVFSRACQYMDSYTIHTKLLGIYEISEKF-- 406 Query: 758 TIRAREILAYGAKLLPPSRNTELWDSFEIFELKHGDKETYKDML 801 +A E+ AK + + +W S+ F + H +++ + +L Sbjct: 407 -DKAAELFKATAKKFGGEKVS-IWVSWGDFLISHNEEQEARTIL 448 >5NLG-A nrPDB Length = 314 Score = 43.2 bits (100), Expect = 5e-04, Method: Composition-based stats. Identities = 42/226 (18%), Positives = 80/226 (35%), Gaps = 34/226 (15%) Query: 603 ESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDC 662 ES +E+ L +W+ Y+ + QL E R L E+ALK + Sbjct: 52 ESVADFER--LLIGNPNSSVVWMNYM----AFQLQLSEIEKARELAERALKTINFREEAE 105 Query: 663 K-TIFIAYSVFE------ERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISK 715 K I+IA E E + + S++ + + + + + + Sbjct: 106 KLNIWIAMLNLENTFGTEETLEEVFSRACQYMDSYTIHTKLLGIYEISEKFDKAAELFKA 165 Query: 716 AESTLG--------------PSVT-----RELYQECIQILPNSKAVEFVIKFSDFESSIG 756 G S R + ++ LP +E V KF+ E + G Sbjct: 166 TAKKFGGEKVSIWVSWGDFLISHNEEQEARTILGNALKALPKRNHIEVVRKFAQLEFAKG 225 Query: 757 ETIRAREILAYGAKLLPPSRNTELWDSFEIFELKHGDKETYKDMLK 802 + R R + + + + +LW+ + E+K DK+ +D+ + Sbjct: 226 DPERGRSL--FEGLVADAPKRIDLWNVYVDQEVKAKDKKKVEDLFE 269 Score = 42.4 bits (98), Expect = 9e-04, Method: Composition-based stats. Identities = 45/236 (19%), Positives = 88/236 (37%), Gaps = 27/236 (11%) Query: 378 LQAHMATFESLINLYDIYLNDVALRQDSNLVETWMKRVSLQ---KSAAEKCNVYSEAILK 434 Q ++ E L + L + R+++ + W+ ++L+ + V+S A Sbjct: 77 FQLQLSEIEKARELAERALKTINFREEAEKLNIWIAMLNLENTFGTEETLEEVFSRACQY 136 Query: 435 IDPRKVGTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLKVPYPYIEDLEEIYLNWADR 494 +D + T +Y S A EL+ + K + + I+++W D Sbjct: 137 MDSYTIHT---------KLLGIYEISEKFDKAAELFKATAK---KFGGEKVSIWVSWGDF 184 Query: 495 ELDKEGVERAFSILEDAL-HVPTNPEILLEKYK---NGHRKIPAQTV-LFNSLRIWS-KY 548 + + A +IL +AL +P I + + + P + LF L + K Sbjct: 185 LISHNEEQEARTILGNALKALPKRNHIEVVRKFAQLEFAKGDPERGRSLFEGLVADAPKR 244 Query: 549 IDYLEAYCPKDANSSDKIFNKTKMAYNTVIDLRLITPAMAENFALFLQNHYEVMES 604 ID Y ++ + DK K + + +I ++ F +LQ ES Sbjct: 245 IDLWNVYVDQEVKAKDK--KKVEDLFERIITKKITRKQAKFFFNKWLQ----FEES 294 Score = 29.3 bits (64), Expect = 8.2, Method: Composition-based stats. Identities = 35/206 (16%), Positives = 73/206 (35%), Gaps = 41/206 (19%) Query: 305 LILSLAKYYISRGRLDSCGDLLKKSLQQTLRYSDFDRIYNFYLLFEQECSQF-ILGKLKE 363 + ++ + + ++ +L +++L+ F +E + I + Sbjct: 70 VWMNYMAFQLQLSEIEKARELAERALKTI--------------NFREEAEKLNIWIAMLN 115 Query: 364 NDSKFFNQKDWTEKLQAHMATFESLINLYDIYLNDVALRQDSNLVETWMKRVSLQKSAAE 423 ++ F ++ T E + + Y++ T ++ +E Sbjct: 116 LENTFGTEE-----------TLEEVFSRACQYMDS----------YTIHTKLLGIYEISE 154 Query: 424 KCNVYSEAILKIDPRKVGTPGSFGRLWCSYGDLYWRSNAISTARELWTQSLKVPYPYIED 483 K + +E + K +K G G +W S+GD N AR + +LK P Sbjct: 155 KFDKAAE-LFKATAKKFG--GEKVSIWVSWGDFLISHNEEQEARTILGNALKA-LPKRNH 210 Query: 484 LEEIYLNWADRELDKEGVERAFSILE 509 +E + +A E K ER S+ E Sbjct: 211 IEVVR-KFAQLEFAKGDPERGRSLFE 235 Score = 28.9 bits (63), Expect = 8.9, Method: Composition-based stats. Identities = 30/164 (18%), Positives = 65/164 (39%), Gaps = 15/164 (9%) Query: 639 LSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSV 698 +PE + FE+ L N +++ Y F+ ++S I K+ E+ R Sbjct: 49 RAPESVAD-FERLLIGN-PN---SSVVWMNYMAFQLQLS-EIEKARELAERALKTINFR- 101 Query: 699 STHLESRLQLWRMCISKAESTLGPSVT-RELYQECIQILPNSKAVEFVIKFSDFESSIGE 757 +L +W + + E+T G T E++ Q + + ++ + Sbjct: 102 --EEAEKLNIW-IAMLNLENTFGTEETLEEVFSRACQYMDSYTIHTKLLGIYEISEKF-- 156 Query: 758 TIRAREILAYGAKLLPPSRNTELWDSFEIFELKHGDKETYKDML 801 +A E+ AK + + +W S+ F + H +++ + +L Sbjct: 157 -DKAAELFKATAKKFGGEKVS-IWVSWGDFLISHNEEQEARTIL 198 >5JJX-A nrPDB Length = 314 Score = 41.6 bits (96), Expect = 0.002, Method: Composition-based stats. Identities = 33/142 (23%), Positives = 55/142 (38%), Gaps = 16/142 (11%) Query: 617 PEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERI 676 + ELW+E+L S L EH+ LFEKA+K C I++ Y + + Sbjct: 63 FPLTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVK-----DYICPNIWLEYGQYS--V 115 Query: 677 SGLISK-SIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTLGPSVTRELYQECIQI 735 G+ K +E +R SV H+ L LW + + R ++ Sbjct: 116 GGIGQKGGLEKVRSVFERALSSVGLHMTKGLALWEAY--REFESAIVEAAR------LEK 167 Query: 736 LPNSKAVEFVIKFSDFESSIGE 757 + + + I D E++ E Sbjct: 168 VHSLFRRQLAIPLYDMEATFAE 189 Score = 35.9 bits (81), Expect = 0.088, Method: Composition-based stats. Identities = 33/176 (18%), Positives = 64/176 (36%), Gaps = 21/176 (11%) Query: 602 MESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGID 661 + ++EK + + +W+EY + + E +R +FE+AL ++ + Sbjct: 88 EHVYDLFEKAVKDYICPN---IWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTK 144 Query: 662 CKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTLG 721 ++ AY FE I L + + ++ L + +E + Sbjct: 145 GLALWEAYREFESAIVEAAR-----LEKVHSLFRRQLAIPLYDMEATFAEYEEWSEDPIP 199 Query: 722 PSVTRELYQECIQILPNSKAVEFVI------------KFSDFESSIGETIRAREIL 765 SV + Y + +Q L K E + + DFE IG+ R + I Sbjct: 200 ESVIQN-YNKALQQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIF 254 >5JPZ-A nrPDB Length = 509 Score = 41.6 bits (96), Expect = 0.002, Method: Composition-based stats. Identities = 32/141 (22%), Positives = 52/141 (36%), Gaps = 14/141 (9%) Query: 617 PEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERI 676 + ELW+E+L S L EH+ LFEKA+K C I++ Y + Sbjct: 77 FPLTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVK-----DYICPNIWLEYGQYSVGG 131 Query: 677 SGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTLGPSVTRELYQECIQIL 736 G +E +R SV H+ L LW + + R ++ + Sbjct: 132 IGQ-KGGLEKVRSVFERALSSVGLHMTKGLALWEAY--REFESAIVEAAR------LEKV 182 Query: 737 PNSKAVEFVIKFSDFESSIGE 757 + + I D E++ E Sbjct: 183 HSLFRRQLAIPLYDMEATFAE 203 Score = 35.9 bits (81), Expect = 0.089, Method: Composition-based stats. Identities = 33/176 (18%), Positives = 64/176 (36%), Gaps = 21/176 (11%) Query: 602 MESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGID 661 + ++EK + + +W+EY + + E +R +FE+AL ++ + Sbjct: 102 EHVYDLFEKAVKDYICPN---IWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTK 158 Query: 662 CKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTLG 721 ++ AY FE I L + + ++ L + +E + Sbjct: 159 GLALWEAYREFESAIVEAAR-----LEKVHSLFRRQLAIPLYDMEATFAEYEEWSEDPIP 213 Query: 722 PSVTRELYQECIQILPNSKAVEFVI------------KFSDFESSIGETIRAREIL 765 SV + Y + +Q L K E + + DFE IG+ R + I Sbjct: 214 ESVIQN-YNKALQQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIF 268 >5CTQ-A nrPDB Length = 561 Score = 41.2 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 32/141 (22%), Positives = 52/141 (36%), Gaps = 14/141 (9%) Query: 617 PEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERI 676 + ELW+E+L S L EH+ LFEKA+K C I++ Y + Sbjct: 92 FPLTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVK-----DYICPNIWLEYGQYSVGG 146 Query: 677 SGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTLGPSVTRELYQECIQIL 736 G +E +R SV H+ L LW + + R ++ + Sbjct: 147 IGQ-KGGLEKVRSVFERALSSVGLHMTKGLALWEAY--REFESAIVEAAR------LEKV 197 Query: 737 PNSKAVEFVIKFSDFESSIGE 757 + + I D E++ E Sbjct: 198 HSLFRRQLAIPLYDMEATFAE 218 Score = 35.5 bits (80), Expect = 0.094, Method: Composition-based stats. Identities = 33/176 (18%), Positives = 64/176 (36%), Gaps = 21/176 (11%) Query: 602 MESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGID 661 + ++EK + + +W+EY + + E +R +FE+AL ++ + Sbjct: 117 EHVYDLFEKAVKDYICPN---IWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTK 173 Query: 662 CKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTLG 721 ++ AY FE I L + + ++ L + +E + Sbjct: 174 GLALWEAYREFESAIVEAAR-----LEKVHSLFRRQLAIPLYDMEATFAEYEEWSEDPIP 228 Query: 722 PSVTRELYQECIQILPNSKAVEFVI------------KFSDFESSIGETIRAREIL 765 SV + Y + +Q L K E + + DFE IG+ R + I Sbjct: 229 ESVIQN-YNKALQQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIF 283 >2OND-A nrPDB Length = 308 Score = 40.9 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 48/283 (16%), Positives = 103/283 (36%), Gaps = 39/283 (13%) Query: 540 NSLRIWSKYIDYLEAYCPKDANSSDKIFNKTKMAYNTVIDLRLITPAMAENFALFLQNHY 599 + +W KYI + ++ + + + I + AY + + P + A +L+ Sbjct: 6 QQVDMWKKYIQWEKSNPLRTEDQTL-ITKRVMFAYEQCLLVLGHHPDIWYEAAQYLEQSS 64 Query: 600 EV--------------MESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIR 645 ++ E+ +YE+ I + + Y A ++ S + E + Sbjct: 65 KLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNM----LLYFAYA-DYEESRMKYEKVH 119 Query: 646 FLFEKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESR 705 ++ + L ID ++I Y F R G+ S + I ++ E Sbjct: 120 SIYNRLL---AIEDIDPTLVYIQYMKFARRAEGIKSGRM-IFKKAR-----------EDA 164 Query: 706 LQLWRMCISKAESTLGPSVTRELYQECIQILPNSKA--VEFVIKFSDFESSIGETIRARE 763 + ++ A S + + + ++ E+V+ + D+ S + E R Sbjct: 165 RTRHHVYVTAALMEYYCSKDKSVAFKIFELGLKKYGDIPEYVLAYIDYLSHLNEDNNTRV 224 Query: 764 ILA--YGAKLLPPSRNTELWDSFEIFELKHGDKETYKDMLKMK 804 + + LPP ++ E+W F FE GD + + K + Sbjct: 225 LFERVLTSGSLPPEKSGEIWARFLAFESNIGDLASILKVEKRR 267 >5GMK-d nrPDB Length = 687 Score = 39.3 bits (90), Expect = 0.007, Method: Composition-based stats. Identities = 37/187 (19%), Positives = 67/187 (35%), Gaps = 18/187 (9%) Query: 666 FIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTLGPSVT 725 +I Y+ FE + ++ I R ++ + S + LW I + Sbjct: 68 WIRYAQFEIEQHDM-RRARSIFERALLVDS--------SFIPLWIRYIDAELKVKCINHA 118 Query: 726 RELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILA-YGAKLLPPSRNTELWDSF 784 R L I LP + + K+ E S+ R + + + L P N W+SF Sbjct: 119 RNLMNRAISTLP--RVDKLWYKYLIVEESLNNVEIVRSLYTKWCS--LEPGVNA--WNSF 172 Query: 785 EIFELKHGDKETYKDMLKMKKVLESNMLIDSASVSHEE--GNINFVAAATSHAPNSHTLT 842 FE++ + +++ + M V E GN F + S A ++ Sbjct: 173 VDFEIRQKNWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANL 232 Query: 843 QSTSSYS 849 Q+ +S Sbjct: 233 QNLQIWS 239 Score = 30.5 bits (67), Expect = 3.2, Method: Composition-based stats. Identities = 38/201 (18%), Positives = 80/201 (39%), Gaps = 23/201 (11%) Query: 589 ENFALFLQNHYEVMESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLF 648 +A F +++ + ++E+ L LWI Y++ +L H R L Sbjct: 69 IRYAQFEIEQHDMRRARSIFER--ALLVDSSFIPLWIRYIDA----ELKVKCINHARNLM 122 Query: 649 EKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQL 708 +A+ L +D ++ Y + EE ++ ++EI+R + LE + Sbjct: 123 NRAISTL--PRVD--KLWYKYLIVEESLN-----NVEIVR-----SLYTKWCSLEPGVNA 168 Query: 709 WRMCISKAESTLGPSVTRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYG 768 W + + RE+Y + + P ++ +K+ FE+ G T R + + Sbjct: 169 WNSFVDFEIRQKNWNGVREIYSKYVMAHPQ---MQTWLKWVRFENRHGNTEFTRSVYSLA 225 Query: 769 AKLLPPSRNTELWDSFEIFEL 789 + +N ++W E+ +L Sbjct: 226 IDTVANLQNLQIWSDMEVAKL 246 >5LJ5-S nrPDB Length = 687 Score = 39.3 bits (90), Expect = 0.007, Method: Composition-based stats. Identities = 29/195 (14%), Positives = 69/195 (35%), Gaps = 45/195 (23%) Query: 445 SFGRLWCSYGDLYWRSNAISTARELWTQSLKVPYPYIEDLEEIYLNWADRELDKEGVERA 504 +F ++W Y R + + AR++ +++ + + + + + E+ + +R Sbjct: 402 TFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPK-----AKTFKGYIELEVKLKEFDRV 456 Query: 505 FSILEDALHVPTNPEILLEKYKNGHRKIPAQTVLFNSLRIWSKYIDYLEAYCPKDANSSD 564 I E + P + L+IWS+Y + E + Sbjct: 457 RKIYEKFI-----------------EFQP------SDLQIWSQYGELEE---------NL 484 Query: 565 KIFNKTKMAYNTVID------LRLITPAMAENFALFLQNHYEVMESFQVYEKTIPLFPPE 618 +++ + Y +D + + + + F E ++ ++Y + + L Sbjct: 485 GDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELNQYS 544 Query: 619 IQYELWIEYLEVATS 633 Q WIE+ TS Sbjct: 545 PQS--WIEFAMYQTS 557 Score = 38.5 bits (88), Expect = 0.014, Method: Composition-based stats. Identities = 37/187 (19%), Positives = 67/187 (35%), Gaps = 18/187 (9%) Query: 666 FIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTLGPSVT 725 +I Y+ FE + ++ I R ++ + S + LW I + Sbjct: 68 WIRYAQFEIEQHDM-RRARSIFERALLVDS--------SFIPLWIRYIDAELKVKCINHA 118 Query: 726 RELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILA-YGAKLLPPSRNTELWDSF 784 R L I LP + + K+ E S+ R + + + L P N W+SF Sbjct: 119 RNLMNRAISTLP--RVDKLWYKYLIVEESLNNVEIVRSLYTKWCS--LEPGVNA--WNSF 172 Query: 785 EIFELKHGDKETYKDMLKMKKVLESNMLIDSASVSHEE--GNINFVAAATSHAPNSHTLT 842 FE++ + +++ + M V E GN F + S A ++ Sbjct: 173 VDFEIRQKNWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANL 232 Query: 843 QSTSSYS 849 Q+ +S Sbjct: 233 QNLQIWS 239 Score = 32.0 bits (71), Expect = 1.0, Method: Composition-based stats. Identities = 40/210 (19%), Positives = 71/210 (33%), Gaps = 29/210 (13%) Query: 621 YELWIEYLEVATSHQLSSLSPEHIRFLFEKALKNLCSNGIDCKTIFIAYSVFEERISGLI 680 ++W+ Y + H R + KA+ LC KT F Y E + Sbjct: 404 SKIWLMYAKFLIRHD----DVPKARKILGKAI-GLCP---KAKT-FKGYIELEVK----- 449 Query: 681 SKSIEILRRGAVIGTVSVSTHLESRLQLWRMCISKAESTLGP-SVTRELYQECI----QI 735 ++ R I + LQ+W + E LG R +Y + Sbjct: 450 ---LKEFDRVRKIYEKFIEFQPSD-LQIWSQY-GELEENLGDWDRVRGIYTIALDENSDF 504 Query: 736 LPNSKAVEFVIKFSDFESSIGETIRAREILAYGAKLLPPSRNTELWDSFEIFELKHGDKE 795 L + + K+ FE+ E +AR++ +L N S+ F + Sbjct: 505 LTKEAKIVLLQKYITFETESQEFEKARKLYRRYLEL-----NQYSPQSWIEFAMYQTSTP 559 Query: 796 TYKDMLKMKKVLESNMLIDSASVSHEEGNI 825 T + +L + K+ N+ D +E + Sbjct: 560 TEQQLLDLAKLQSENVDEDIEFEITDENKL 589 Score = 29.7 bits (65), Expect = 5.6, Method: Composition-based stats. Identities = 38/201 (18%), Positives = 80/201 (39%), Gaps = 23/201 (11%) Query: 589 ENFALFLQNHYEVMESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLF 648 +A F +++ + ++E+ L LWI Y++ +L H R L Sbjct: 69 IRYAQFEIEQHDMRRARSIFER--ALLVDSSFIPLWIRYIDA----ELKVKCINHARNLM 122 Query: 649 EKALKNLCSNGIDCKTIFIAYSVFEERISGLISKSIEILRRGAVIGTVSVSTHLESRLQL 708 +A+ L +D ++ Y + EE ++ ++EI+R + LE + Sbjct: 123 NRAISTL--PRVD--KLWYKYLIVEESLN-----NVEIVR-----SLYTKWCSLEPGVNA 168 Query: 709 WRMCISKAESTLGPSVTRELYQECIQILPNSKAVEFVIKFSDFESSIGETIRAREILAYG 768 W + + RE+Y + + P ++ +K+ FE+ G T R + + Sbjct: 169 WNSFVDFEIRQKNWNGVREIYSKYVMAHPQ---MQTWLKWVRFENRHGNTEFTRSVYSLA 225 Query: 769 AKLLPPSRNTELWDSFEIFEL 789 + +N ++W E+ +L Sbjct: 226 IDTVANLQNLQIWSDMEVAKL 246 >6G70-A nrPDB Length = 670 Score = 34.3 bits (77), Expect = 0.25, Method: Composition-based stats. Identities = 22/78 (28%), Positives = 37/78 (47%), Gaps = 9/78 (11%) Query: 16 ENIRNDEDVAFEYEIQKTPQNILTWKRYIEYWKE-----EGRTDKQIRWLYERFCSQFVT 70 +NI+ ++V + +Q P ++ W YI + KE + T+ IR +E T Sbjct: 146 DNIKQSDEV-YRRGLQAIPLSVDLWIHYINFLKETLDPGDQETNTTIRGTFEHAVLAAGT 204 Query: 71 D---TSIWEDYIRWESTK 85 D +WE YI WE+ + Sbjct: 205 DFRSDKLWEMYINWENEQ 222 Score = 32.0 bits (71), Expect = 1.0, Method: Composition-based stats. Identities = 22/149 (14%), Positives = 50/149 (33%), Gaps = 33/149 (22%) Query: 450 WCSYGDLYWRSNAISTARELWTQSLKVPYPYIEDLEEIYLNWADRELDKEGVERAFSILE 509 W + N + AR+ + + V YPY + +AD E + ++++ + Sbjct: 101 WVYLLQYVEQENHLMAARKAFDKFF-VHYPYC---YGYWKKYADLEKRHDNIKQSDEVYR 156 Query: 510 DAL-HVPTNPEI-------LLEKYKNGHRKIPAQTV------------LFNSLRIWSKYI 549 L +P + ++ L E G ++ F S ++W YI Sbjct: 157 RGLQAIPLSVDLWIHYINFLKETLDPGDQETNTTIRGTFEHAVLAAGTDFRSDKLWEMYI 216 Query: 550 DYLEAYCPKDANSSDKIFNKTKMAYNTVI 578 ++ + + Y+ ++ Sbjct: 217 NWE---------NEQGNLREVTAVYDRIL 236 >1VPK-A nrPDB Length = 378 Score = 33.2 bits (74), Expect = 0.56, Method: Composition-based stats. Identities = 23/90 (25%), Positives = 44/90 (48%), Gaps = 10/90 (11%) Query: 214 ILERYLKVAPQQKRNESLATLALTRDNITIKSVYEKY----LPQDENSGKYLPSSELPFE 269 ++++ +KV P + + L+L D + I S + +P DE S + FE Sbjct: 86 VIQKMVKVLPDE-----ITELSLEGDALVISSGSTVFRITTMPADEFPEITPAESGITFE 140 Query: 270 LNFNYLASL-EKLGLDNQYEEFMRQMNGIY 298 ++ + L + EK+ +EFMR +NG++ Sbjct: 141 VDTSLLEEMVEKVIFAAAKDEFMRNLNGVF 170 >3RM5-A nrPDB Length = 550 Score = 32.8 bits (73), Expect = 0.76, Method: Composition-based stats. Identities = 26/105 (24%), Positives = 39/105 (37%), Gaps = 10/105 (9%) Query: 392 YDIYLNDVALRQDSNLVETWMKRVSLQKSAAEKCNVYSEAILKIDPRKVGTPGSFGRLWC 451 Y Y NDV+ R + W + V+ S Y EA+ K+ + GS WC Sbjct: 444 YSRYFNDVSRRGN------WQELVA---SLTPCLMGYGEALTKMKGKVTAPEGSVYHEWC 494 Query: 452 SYGDLYWRSNAISTARELWTQSLKV-PYPYIEDLEEIYLNWADRE 495 W A+ +L L+ P ++ L IY + E Sbjct: 495 ETYASSWYREAMDEGEKLLNHILETYPPEQLDTLVTIYAEVCELE 539 >3VSN-A nrPDB Length = 659 Score = 32.4 bits (72), Expect = 0.90, Method: Composition-based stats. Identities = 16/58 (27%), Positives = 30/58 (51%), Gaps = 6/58 (10%) Query: 536 TVLFNSLRIWSKYIDY------LEAYCPKDANSSDKIFNKTKMAYNTVIDLRLITPAM 587 +F++L W+ D+ L YC + N+SD ++ ++AYN + LR+I + Sbjct: 63 NTVFDNLSPWTSVPDFGTVCHTLIGYCVRYNNTSDTLYQNPELAYNLINGLRIICSKL 120 >3OPY-A nrPDB Length = 989 Score = 31.2 bits (69), Expect = 2.0, Method: Composition-based stats. Identities = 14/99 (14%), Positives = 33/99 (33%), Gaps = 11/99 (11%) Query: 451 CSYGDLYWRSNAISTARELWTQSLKVPYPYIEDLEEIYLNWADRE-----------LDKE 499 C++ + R + + +P P I LE + E ++ + Sbjct: 501 CAFDRFLATVQGVDAVRAVLESTPAIPSPVISILENKIVRQPLVESVAQTKTVSAAIEAK 560 Query: 500 GVERAFSILEDALHVPTNPEILLEKYKNGHRKIPAQTVL 538 ++A + + + + KY +G +P + L Sbjct: 561 DFDKALQLRDQEFATSYENFLSVSKYDDGSYLVPESSRL 599 >1W6K-A nrPDB Length = 732 Score = 30.8 bits (68), Expect = 2.3, Method: Composition-based stats. Identities = 18/64 (28%), Positives = 27/64 (42%), Gaps = 15/64 (23%) Query: 294 MNGIYPDKWLF----------LILSLAKYYISRG-----RLDSCGDLLKKSLQQTLRYSD 338 +N ++P+ WLF L + Y+ RL + D L +SL+Q L D Sbjct: 208 LNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYCYAVRLSAAEDPLVQSLRQELYVED 267 Query: 339 FDRI 342 F I Sbjct: 268 FASI 271 >1W3B-A nrPDB Length = 388 Score = 30.8 bits (68), Expect = 2.6, Method: Composition-based stats. Identities = 22/121 (18%), Positives = 47/121 (38%), Gaps = 13/121 (10%) Query: 395 YLNDVALRQDSNLVETWMKRVSL-QKSAAEKCNVYSEAILKIDPRKVGTPGSFGRLWCSY 453 YL ++L + +V + V Q + Y AI P F +C+ Sbjct: 226 YLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIEL-------QPH-FPDAYCNL 277 Query: 454 GDLYWRSNAISTARELWTQSLKVPYPYIEDLEEIYLNWADRELDKEGVERAFSILEDALH 513 + +++ A + + +L++ + + L N A+ + ++ +E A + AL Sbjct: 278 ANALKEKGSVAEAEDCYNTALRLCPTHADSLN----NLANIKREQGNIEEAVRLYRKALE 333 Query: 514 V 514 V Sbjct: 334 V 334 >5DGR-A nrPDB Length = 586 Score = 30.1 bits (66), Expect = 4.5, Method: Composition-based stats. Identities = 14/59 (23%), Positives = 27/59 (45%), Gaps = 1/59 (1%) Query: 756 GETIRAREILAYGAKLLPPSRNTELWDSFEIFELKHGDKETYKDMLKMKKVLESNMLID 814 G+ + L+YG L P +W+ +E+ D+E+ D +++ V E+ D Sbjct: 142 GDVSKYFSHLSYGNYLNPQQTPMVVWNMLTAYEVLE-DEESIADFTRVRLVEEALYGAD 199 >5IC8-A nrPDB Length = 334 Score = 30.1 bits (66), Expect = 4.8, Method: Composition-based stats. Identities = 13/57 (22%), Positives = 26/57 (45%), Gaps = 6/57 (10%) Query: 597 NHYEVMESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALK 653 +H +F ++E+ + ELW+ YLE A + + + R + +AL+ Sbjct: 5 SHASQARTFGIFERAV--LKHPGSIELWLAYLEFAAQVKAT----KRWRRIMTRALR 55 >5OQL-E nrPDB Length = 414 Score = 29.7 bits (65), Expect = 5.2, Method: Composition-based stats. Identities = 13/57 (22%), Positives = 26/57 (45%), Gaps = 6/57 (10%) Query: 597 NHYEVMESFQVYEKTIPLFPPEIQYELWIEYLEVATSHQLSSLSPEHIRFLFEKALK 653 +H +F ++E+ + ELW+ YLE A + + + R + +AL+ Sbjct: 85 SHASQARTFGIFERAV--LKHPGSIELWLAYLEFAAQVKAT----KRWRRIMTRALR 135 >6BMQ-A nrPDB Length = 523 Score = 28.9 bits (63), Expect = 9.4, Method: Composition-based stats. Identities = 14/67 (20%), Positives = 29/67 (43%), Gaps = 5/67 (7%) Query: 792 GDKETYKDMLKMKKVLESNMLIDSASVSHEEGNINFVAAATSHAPNSHTLTQSTSSYSIN 851 GD+ +D+L++ L ++ + V+ E F+ + P + S+ +Y Sbjct: 76 GDENERRDVLRLAMELGADYIDVELQVASE-----FIKSIDGKKPGKFKVIVSSHNYQNT 130 Query: 852 PDEIELD 858 P +LD Sbjct: 131 PSVEDLD 137 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.315 0.130 0.360 Lambda K H 0.267 0.0404 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 33,026,335 Number of Sequences: 36641 Number of extensions: 1347098 Number of successful extensions: 3950 Number of sequences better than 10.0: 28 Number of HSP's better than 10.0 without gapping: 21 Number of HSP's successfully gapped in prelim test: 39 Number of HSP's that attempted gapping in prelim test: 3785 Number of HSP's gapped (non-prelim): 134 length of query: 859 length of database: 10,336,785 effective HSP length: 105 effective length of query: 754 effective length of database: 6,489,480 effective search space: 4893067920 effective search space used: 4893067920 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 63 (28.9 bits)