BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q03774 (444 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2VDU-B nrPDB 911 0.0 4V6W-Ag nrPDB 42 5e-04 3DM0-A nrPDB 42 6e-04 5M25-A nrPDB 35 0.055 2H9P-A nrPDB 34 0.11 1ZVU-A nrPDB 34 0.12 6ID0-T nrPDB 34 0.12 1ZVT-A nrPDB 34 0.14 6ELZ-p nrPDB 33 0.20 6G51-g nrPDB 32 0.37 5WYJ-BC nrPDB 32 0.39 5K1B-B nrPDB 32 0.62 6HHQ-h nrPDB 31 0.90 4G56-B nrPDB 31 1.2 5YZG-W nrPDB 31 1.2 6QDV-o nrPDB 30 1.4 2PM9-A nrPDB 30 1.6 3ACP-A nrPDB 30 2.4 1U8V-A nrPDB 30 2.5 3WR5-A nrPDB 30 2.9 4JJJ-A nrPDB 29 3.3 4V7E-Bg nrPDB 29 4.7 1J71-A nrPDB 28 5.4 3QO8-A nrPDB 28 5.5 5OQJ-7 nrPDB 28 6.7 2GO1-A nrPDB 28 6.8 4XFV-A nrPDB 28 6.8 3FN4-A nrPDB 28 7.0 5SVA-Z nrPDB 28 7.5 5Y88-O nrPDB 28 7.6 5W5F-A nrPDB 28 7.8 1UC6-A nrPDB 28 8.2 4BTS-AR nrPDB 28 8.6 5WLC-LN nrPDB 28 8.8 5H72-A nrPDB 28 9.0 >2VDU-B nrPDB Length = 450 Score = 911 bits (2355), Expect = 0.0, Method: Compositional matrix adjust. Identities = 444/444 (100%), Positives = 444/444 (100%) Query: 1 MSVIHPLQNLLTSRDGSLVFAIIKNCILSFKYQSPNHWEFAGKWSDDFDKIQESRNTTAK 60 MSVIHPLQNLLTSRDGSLVFAIIKNCILSFKYQSPNHWEFAGKWSDDFDKIQESRNTTAK Sbjct: 1 MSVIHPLQNLLTSRDGSLVFAIIKNCILSFKYQSPNHWEFAGKWSDDFDKIQESRNTTAK 60 Query: 61 EQQGQSSENENENKKLKSNKGDSIKRTAAKVPSPGLGAPPIYSYIRNLRLTSDESRLIAC 120 EQQGQSSENENENKKLKSNKGDSIKRTAAKVPSPGLGAPPIYSYIRNLRLTSDESRLIAC Sbjct: 61 EQQGQSSENENENKKLKSNKGDSIKRTAAKVPSPGLGAPPIYSYIRNLRLTSDESRLIAC 120 Query: 121 ADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFGDVYSIDINS 180 ADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFGDVYSIDINS Sbjct: 121 ADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFGDVYSIDINS 180 Query: 181 IPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGH 240 IPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGH Sbjct: 181 IPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGH 240 Query: 241 KHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAPPRFQN 300 KHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAPPRFQN Sbjct: 241 KHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAPPRFQN 300 Query: 301 ENNDIIEFAVSKIIKSKNLPFVAFFVEATKCIIILEMSEKQKGDLALKQIITFPYNVISL 360 ENNDIIEFAVSKIIKSKNLPFVAFFVEATKCIIILEMSEKQKGDLALKQIITFPYNVISL Sbjct: 301 ENNDIIEFAVSKIIKSKNLPFVAFFVEATKCIIILEMSEKQKGDLALKQIITFPYNVISL 360 Query: 361 SAHNDEFQVTLDNKESSGVQKNFAKFIEYNLNENSFVVNNEKSNEFDSAIIQSVQGDSNL 420 SAHNDEFQVTLDNKESSGVQKNFAKFIEYNLNENSFVVNNEKSNEFDSAIIQSVQGDSNL Sbjct: 361 SAHNDEFQVTLDNKESSGVQKNFAKFIEYNLNENSFVVNNEKSNEFDSAIIQSVQGDSNL 420 Query: 421 VTKKEEIYPLYNVSSLRKHGEHYS 444 VTKKEEIYPLYNVSSLRKHGEHYS Sbjct: 421 VTKKEEIYPLYNVSSLRKHGEHYS 444 >4V6W-Ag nrPDB Length = 318 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 48/200 (24%), Positives = 96/200 (48%), Gaps = 23/200 (11%) Query: 104 YIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRF-CFSKRPNAISIAEDDT 162 +I ++ L+SD + ++ D++L ++D+ K +RF +K +++ + D+ Sbjct: 66 FISDVVLSSDGNYALS-GSWDQTLRLWDLAAG-----KTTRRFEGHTKDVLSVAFSADNR 119 Query: 163 TVIIA--DKFGDVYSIDINSIPEEKFT-QEPILGHVSMLTDVHLIKDSDGHQFIITSDRD 219 ++ DK ++ N++ E KFT QE GH ++ V + + I++ D Sbjct: 120 QIVSGSRDKTIKLW----NTLAECKFTIQED--GHTDWVSCVRF-SPNHSNPIIVSCGWD 172 Query: 220 EHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG-DDKIFAWDWKTGKNLSTF 278 +K+ + C + + GH +++++ D L ++GG D K WD GKNL T Sbjct: 173 RTVKVWNLANCKLKNN-HHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTL 231 Query: 279 DYNSLIKPYLNDQHLAPPRF 298 ++N +I N +P R+ Sbjct: 232 EHNDII----NALCFSPNRY 247 Score = 32.7 bits (73), Expect = 0.32, Method: Compositional matrix adjust. Identities = 36/140 (25%), Positives = 57/140 (40%), Gaps = 28/140 (20%) Query: 191 ILGHVSMLTDVHL-IKDSDGHQFIITSDRDEHIKISH----------YPQCFIVDKWLFG 239 ++GH +T + KD D II++ RD+ + + YPQ K L+G Sbjct: 11 LIGHNGWVTQIATNPKDPD---TIISASRDKTLIVWKLTRDEDTNYGYPQ-----KRLYG 62 Query: 240 HKHFVSSICCGKDY-LLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAPPRF 298 H HF+S + D LS D + WD GK F+ ++ + + F Sbjct: 63 HSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHT--------KDVLSVAF 114 Query: 299 QNENNDIIEFAVSKIIKSKN 318 +N I+ + K IK N Sbjct: 115 SADNRQIVSGSRDKTIKLWN 134 >3DM0-A nrPDB Length = 694 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 30/108 (27%), Positives = 54/108 (50%), Gaps = 4/108 (3%) Query: 179 NSIPEEKFT-QEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWL 237 N++ E K+T E GH ++ V ++ I+++ D+ +K+ + C + L Sbjct: 500 NTLGECKYTISEGGEGHRDWVSCVRFSPNTL-QPTIVSASWDKTVKVWNLSNCKLRST-L 557 Query: 238 FGHKHFVSSICCGKDYLLLSAGGDDKI-FAWDWKTGKNLSTFDYNSLI 284 GH +VS++ D L ++GG D + WD GK L + + NS+I Sbjct: 558 AGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEANSVI 605 Score = 29.6 bits (65), Expect = 2.7, Method: Compositional matrix adjust. Identities = 23/90 (25%), Positives = 39/90 (43%), Gaps = 7/90 (7%) Query: 194 HVSMLTDVHLIKDSDGHQFIITSDRDEHI---KISHYPQCF-IVDKWLFGHKHFVSSICC 249 H M+T + D I+++ RD+ I K++ + + + + L GH HFV + Sbjct: 381 HTDMVTAIA--TPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVL 438 Query: 250 GKD-YLLLSAGGDDKIFAWDWKTGKNLSTF 278 D LS D ++ WD G + F Sbjct: 439 SSDGQFALSGSWDGELRLWDLAAGVSTRRF 468 >5M25-A nrPDB Length = 434 Score = 35.4 bits (80), Expect = 0.055, Method: Compositional matrix adjust. Identities = 30/100 (30%), Positives = 50/100 (50%), Gaps = 13/100 (13%) Query: 188 QEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYP--QCFIVDKWLFGHKHFVS 245 ++ I GH ++DV DS+ ++++ D+ +KI +C K L GH ++V Sbjct: 180 EKTISGHKLGISDVAWSSDSN---LLVSASDDKTLKIWDVSSGKCL---KTLKGHSNYV- 232 Query: 246 SICCG---KDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNS 282 CC + L++S D+ + WD KTGK L T +S Sbjct: 233 -FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHS 271 >2H9P-A nrPDB Length = 329 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 34/112 (30%), Positives = 55/112 (49%), Gaps = 14/112 (12%) Query: 176 IDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYP--QCFIV 233 I I + KF ++ I GH ++DV DS+ ++++ D+ +KI +C Sbjct: 64 IKIWGAYDGKF-EKTISGHKLGISDVAWSSDSN---LLVSASDDKTLKIWDVSSGKCL-- 117 Query: 234 DKWLFGHKHFVSSICCG---KDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNS 282 K L GH ++V CC + L++S D+ + WD KTGK L T +S Sbjct: 118 -KTLKGHSNYV--FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHS 166 >1ZVU-A nrPDB Length = 716 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 16/57 (28%), Positives = 31/57 (54%), Gaps = 3/57 (5%) Query: 164 VIIADKFGDVYSIDINSIPEEKFTQEPILGHVSM---LTDVHLIKDSDGHQFIITSD 217 V+ D G Y+ID ++P + EP+ G +++ T H++ +SD + ++ SD Sbjct: 517 VVFVDSTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVDHMLMESDDQKLLMASD 573 >6ID0-T nrPDB Length = 514 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 16/65 (24%), Positives = 30/65 (46%), Gaps = 1/65 (1%) Query: 211 QFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWK 270 + S ++IK +P + L GH ++++ D +L+S + + WDW+ Sbjct: 384 HYTFASGSPDNIKQWKFPDGSFIQN-LSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWR 442 Query: 271 TGKNL 275 TG N Sbjct: 443 TGYNF 447 >1ZVT-A nrPDB Length = 256 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 15/57 (26%), Positives = 30/57 (52%), Gaps = 3/57 (5%) Query: 164 VIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDV---HLIKDSDGHQFIITSD 217 V+ D G Y+ID ++P + EP+ G +++ H++ +SD + ++ SD Sbjct: 47 VVFVDSTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVDHMLMESDDQKLLMASD 103 >6ELZ-p nrPDB Length = 460 Score = 33.5 bits (75), Expect = 0.20, Method: Compositional matrix adjust. Identities = 16/49 (32%), Positives = 26/49 (53%), Gaps = 2/49 (4%) Query: 232 IVDKWLFGHKHFVSSI--CCGKDYLLLSAGGDDKIFAWDWKTGKNLSTF 278 + + L GHK+FVSS+ C +Y+L S D + WD ++ + T Sbjct: 366 VTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTI 414 >6G51-g nrPDB Length = 317 Score = 32.3 bits (72), Expect = 0.37, Method: Compositional matrix adjust. Identities = 22/88 (25%), Positives = 41/88 (46%), Gaps = 6/88 (6%) Query: 212 FIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG-DDKIFAWDWK 270 I++ D+ +K+ + C + GH +++++ D L ++GG D + WD Sbjct: 164 IIVSCGWDKLVKVWNLANCKLKTN-HIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222 Query: 271 TGKNLSTFDYNSLIKPYLNDQHLAPPRF 298 GK+L T D +I N +P R+ Sbjct: 223 EGKHLYTLDGGDII----NALCFSPNRY 246 Score = 28.1 bits (61), Expect = 7.3, Method: Compositional matrix adjust. Identities = 23/83 (27%), Positives = 33/83 (39%), Gaps = 9/83 (10%) Query: 237 LFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAP 295 L GH HFVS + D LS D + WD TG F ++ + + Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHT--------KDVLS 110 Query: 296 PRFQNENNDIIEFAVSKIIKSKN 318 F ++N I+ + K IK N Sbjct: 111 VAFSSDNRQIVSGSRDKTIKLWN 133 >5WYJ-BC nrPDB Length = 817 Score = 32.3 bits (72), Expect = 0.39, Method: Compositional matrix adjust. Identities = 38/138 (27%), Positives = 58/138 (42%), Gaps = 13/138 (9%) Query: 145 RFCFSKRPNAISIAEDDTTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVH 202 R K NA+S++ +D+ A DK ++++ E + + H L DV Sbjct: 487 RHAHEKDINALSVSPNDSIFATASYDKTCKIWNL------ENGELEATLANHKRGLWDVS 540 Query: 203 LIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSIC-CGKDYLLLSAGGD 261 + + + TS D+ +KI F V K L GH + V K L+S G D Sbjct: 541 FCQYD---KLLATSSGDKTVKIWSL-DTFSVMKTLEGHTNAVQRCSFINKQKQLISCGAD 596 Query: 262 DKIFAWDWKTGKNLSTFD 279 I WD +G+ L T D Sbjct: 597 GLIKIWDCSSGECLKTLD 614 >5K1B-B nrPDB Length = 677 Score = 32.0 bits (71), Expect = 0.62, Method: Compositional matrix adjust. Identities = 29/95 (30%), Positives = 49/95 (51%), Gaps = 5/95 (5%) Query: 176 IDINSIPEEKFTQEPILGHVSMLTD-VHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVD 234 I I S+ + K Q+P + + TD V+ I + +I++ D +K+ + + F + Sbjct: 54 IRIWSVNQHK--QDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMS 111 Query: 235 KWLFGHKHFVSSICCGKDY-LLLSAGGDDKIFAWD 268 L HK +V ++ KD L+ SAG D +IF WD Sbjct: 112 T-LRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145 >6HHQ-h nrPDB Length = 319 Score = 31.2 bits (69), Expect = 0.90, Method: Compositional matrix adjust. Identities = 41/178 (23%), Positives = 82/178 (46%), Gaps = 15/178 (8%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 +++ LT+D + ++ A DK+L ++DV + +RF + + +S+ D Sbjct: 68 VQDCTLTADGAYALS-ASWDKTLRLWDVATG-----ETYQRFV-GHKSDVMSVDIDKKAS 120 Query: 165 IIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLI---KDSDGHQFIITSDRDEH 221 +I D +I + +I + +LGH ++ V ++ K D II++ D+ Sbjct: 121 MIISGSRD-KTIKVWTIKGQCLAT--LLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKM 177 Query: 222 IKISHYPQCFIVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWDWKTGKNLSTF 278 +K + Q F ++ GH ++++ D L+ SAG D +I W+ K + T Sbjct: 178 VKAWNLNQ-FQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTL 234 >4G56-B nrPDB Length = 357 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 23/76 (30%), Positives = 37/76 (48%), Gaps = 4/76 (5%) Query: 207 SDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSI--CCGKDYLLLSAGGDDKI 264 SDG Q ++ +D +K+ Q ++ K H V+ + C GKD + LS G D +I Sbjct: 149 SDGTQ-AVSGGKDFSVKVWDLSQKAVL-KSYNAHSSEVNCVAACPGKDTIFLSCGEDGRI 206 Query: 265 FAWDWKTGKNLSTFDY 280 WD + K + D+ Sbjct: 207 LLWDTRKPKPATRIDF 222 >5YZG-W nrPDB Length = 579 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 15/42 (35%), Positives = 21/42 (50%), Gaps = 5/42 (11%) Query: 242 HFVSSICCGKDY-----LLLSAGGDDKIFAWDWKTGKNLSTF 278 H V+ C D+ ++S G+ K+ WDWKT K S F Sbjct: 505 HMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRF 546 >6QDV-o nrPDB Length = 513 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 15/42 (35%), Positives = 21/42 (50%), Gaps = 5/42 (11%) Query: 242 HFVSSICCGKDY-----LLLSAGGDDKIFAWDWKTGKNLSTF 278 H V+ C D+ ++S G+ K+ WDWKT K S F Sbjct: 439 HMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRF 480 >2PM9-A nrPDB Length = 416 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 43/193 (22%), Positives = 83/193 (43%), Gaps = 22/193 (11%) Query: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSK---NVLKLRKRFCFSKRPNAISIAE 159 S ++ ++ + + ++A ++ + ++D++K ++ N L S IS+A Sbjct: 114 SSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAW 173 Query: 160 DDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIK-----------DSD 208 + + +A F S + SI + K +E I H+S + IK +S Sbjct: 174 NQS---LAHVFASAGSSNFASIWDLKAKKEVI--HLSYTSPNSGIKQQLSVVEWHPKNST 228 Query: 209 GHQFIITSDRDEHIKISHYPQCFIVDKWL-FGHKHFVSSI--CCGKDYLLLSAGGDDKIF 265 SD D I I + L GH+ + S+ C ++LLLS+G D+ + Sbjct: 229 RVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVL 288 Query: 266 AWDWKTGKNLSTF 278 W+ ++ + LS F Sbjct: 289 LWNPESAEQLSQF 301 >3ACP-A nrPDB Length = 417 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 32/123 (26%), Positives = 53/123 (43%), Gaps = 23/123 (18%) Query: 165 IIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI 224 I+ GD+ +D N + + Q HVS +T + + +I+S +D +KI Sbjct: 110 ILGTTEGDIKVLDSNFNLQREIDQ----AHVSEITKLKFFPSGEA---LISSSQDMQLKI 162 Query: 225 -----SHYPQCFIVDKWLFGHKHFVSSICC---GKDYLLLSAGGDDKIFAWDWKTGKNLS 276 P+ I GH+ V+ I G++ +LSA D I W+ TG + Sbjct: 163 WSVKDGSNPRTLI------GHRATVTDIAIIDRGRN--VLSASLDGTIRLWECGTGTTIH 214 Query: 277 TFD 279 TF+ Sbjct: 215 TFN 217 >1U8V-A nrPDB Length = 490 Score = 29.6 bits (65), Expect = 2.5, Method: Compositional matrix adjust. Identities = 21/77 (27%), Positives = 39/77 (50%), Gaps = 8/77 (10%) Query: 357 VISLSAHNDEFQVT--LDNKESSGVQKNFAKFIEYNLNENSFVVNNEKSN-EFDSAIIQS 413 + + A N F T +D K + KNF ++++Y + EN +V+ ++ + D + S Sbjct: 103 CVGMDAFNAVFSTTYEIDQKYGTNYHKNFTEYLKY-IQENDLIVDGAMTDPKGDRGLAPS 161 Query: 414 VQGDSNL----VTKKEE 426 Q D +L V K+E+ Sbjct: 162 AQKDPDLFLRIVEKRED 178 >3WR5-A nrPDB Length = 406 Score = 29.6 bits (65), Expect = 2.9, Method: Compositional matrix adjust. Identities = 15/44 (34%), Positives = 25/44 (56%), Gaps = 3/44 (6%) Query: 179 NSIPEEK---FTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRD 219 ++P K FT +LG VS + +++GH F++TSD+D Sbjct: 40 QTLPTPKAIDFTPGQLLGSVSGELGLRKYLEANGHTFVVTSDKD 83 >4JJJ-A nrPDB Length = 642 Score = 29.3 bits (64), Expect = 3.3, Method: Compositional matrix adjust. Identities = 36/141 (25%), Positives = 59/141 (41%), Gaps = 13/141 (9%) Query: 160 DDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGH--VSMLTDVHLIKDSDGHQFIITSD 217 DD T + + D+++ D N + ++T P V ++ H G + I Sbjct: 193 DDFTHGGPNGYLDLFTDDQNYAKQWRYTNAPNADARAVQVMFWAHEWAKEQGKENEIAGL 252 Query: 218 RDEHIKISHYPQCFIVDKWLFGHKHFVSSICC----GKD---YLL---LSAGGD-DKIFA 266 D+ K+ Y + + DK+ + V + C GKD YLL S GG D A Sbjct: 253 MDKASKMGDYLRYAMFDKYFKKIGNCVGATSCPGGQGKDSAHYLLSWYYSWGGSLDTSSA 312 Query: 267 WDWKTGKNLSTFDYNSLIKPY 287 W W+ G + S Y +++ Y Sbjct: 313 WAWRIGSSSSHQGYQNVLAAY 333 >4V7E-Bg nrPDB Length = 380 Score = 28.9 bits (63), Expect = 4.7, Method: Compositional matrix adjust. Identities = 20/67 (29%), Positives = 31/67 (46%), Gaps = 15/67 (22%) Query: 216 SDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICC----GKDYLLLSAGGDDKIFAWDWKT 271 +DRD ++ +S L GHK + SS C ++ L++ GD WD T Sbjct: 141 ADRDGNMPVSRV---------LTGHKGYASS--CQYVPDQETRLITGSGDQTCVLWDVTT 189 Query: 272 GKNLSTF 278 G+ +S F Sbjct: 190 GQRISIF 196 >1J71-A nrPDB Length = 334 Score = 28.5 bits (62), Expect = 5.4, Method: Compositional matrix adjust. Identities = 19/74 (25%), Positives = 38/74 (51%), Gaps = 5/74 (6%) Query: 90 KVPSPGLGAPPIYSYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLK---LRKRF 146 ++PS L ++++ + +++T S LI DSD S+ F + + N+L LR+ + Sbjct: 250 RLPSCDLSGDAVFNFDQGVKITVPLSELI-LKDSDSSICYFGISRNDANILGDNFLRRAY 308 Query: 147 -CFSKRPNAISIAE 159 + IS+A+ Sbjct: 309 IVYDLDDKTISLAQ 322 >3QO8-A nrPDB Length = 485 Score = 28.5 bits (62), Expect = 5.5, Method: Compositional matrix adjust. Identities = 30/104 (28%), Positives = 46/104 (44%), Gaps = 8/104 (7%) Query: 323 AFFVEATKCIIILEMSEKQKGDLA--LKQIITFPYNVISLSAHNDEFQVTLDNKESSGVQ 380 AF VE I++ S+K++GD + +II + L DE NK+ + VQ Sbjct: 6 AFLVEKGGDPEIIKASQKKRGDSVELVDEIIAEYKEWVKLRFDLDEH-----NKKLNSVQ 60 Query: 381 KNFAKFIEYNLNENSFVVNNEK-SNEFDSAIIQSVQGDSNLVTK 423 K K + + + EK SNE I + + D NL +K Sbjct: 61 KEIGKRFKAKEDAKDLIAEKEKLSNEKKEIIEKEAEADKNLRSK 104 >5OQJ-7 nrPDB Length = 843 Score = 28.5 bits (62), Expect = 6.7, Method: Compositional matrix adjust. Identities = 16/47 (34%), Positives = 25/47 (53%), Gaps = 1/47 (2%) Query: 239 GHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIK 285 GHK F S G+ L AGG+D + ++ T KN +++ LI+ Sbjct: 789 GHKRFKSKAVRGEGSLSGLAGGEDMAY-MEYSTNKNKELKEHHPLIR 834 >2GO1-A nrPDB Length = 401 Score = 28.5 bits (62), Expect = 6.8, Method: Compositional matrix adjust. Identities = 15/44 (34%), Positives = 24/44 (54%), Gaps = 3/44 (6%) Query: 179 NSIPEEK---FTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRD 219 ++P K FT +LG VS + +S+GH ++TSD+D Sbjct: 35 QTLPTPKAIDFTPGQLLGSVSGELGLRKYLESNGHTLVVTSDKD 78 >4XFV-A nrPDB Length = 792 Score = 28.5 bits (62), Expect = 6.8, Method: Compositional matrix adjust. Identities = 14/46 (30%), Positives = 24/46 (52%), Gaps = 3/46 (6%) Query: 182 PEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHY 227 P K + GH + +T V + DSD F++++ D H+KI + Sbjct: 50 PNNKGVYATLKGHEAEVTCVRFVPDSD---FMVSASEDHHVKIWKF 92 >3FN4-A nrPDB Length = 401 Score = 28.1 bits (61), Expect = 7.0, Method: Compositional matrix adjust. Identities = 22/67 (32%), Positives = 32/67 (47%), Gaps = 10/67 (14%) Query: 156 SIAEDDTTVIIADKFGDVYSIDINSIPEEK---FTQEPILGHVSMLTDVHLIKDSDGHQF 212 S A DD I DK+ D ++P K FT +LG VS + +S GH+ Sbjct: 18 SYARDDLPRI--DKYPDG-----QTLPTPKAIDFTPGALLGSVSGELGLRKYLESQGHEL 70 Query: 213 IITSDRD 219 ++TS +D Sbjct: 71 VVTSSKD 77 >5SVA-Z nrPDB Length = 843 Score = 28.1 bits (61), Expect = 7.5, Method: Compositional matrix adjust. Identities = 16/47 (34%), Positives = 25/47 (53%), Gaps = 1/47 (2%) Query: 239 GHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIK 285 GHK F S G+ L AGG+D + ++ T KN +++ LI+ Sbjct: 789 GHKRFKSKAVRGEGSLSGLAGGEDMAY-MEYSTNKNKELKEHHPLIR 834 >5Y88-O nrPDB Length = 451 Score = 28.1 bits (61), Expect = 7.6, Method: Compositional matrix adjust. Identities = 22/82 (26%), Positives = 39/82 (47%), Gaps = 5/82 (6%) Query: 191 ILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCG 250 + GHV + DV + SD H ++ + D+ +K + I+ + +GH V ++ Sbjct: 178 LAGHVMTVRDVAV---SDRHPYLFSVSEDKTVKCWDLEKNQIIRDY-YGHLSGVRTVSIH 233 Query: 251 KDY-LLLSAGGDDKIFAWDWKT 271 L+ +AG D I WD +T Sbjct: 234 PTLDLIATAGRDSVIKLWDMRT 255 >5W5F-A nrPDB Length = 163 Score = 28.1 bits (61), Expect = 7.8, Method: Compositional matrix adjust. Identities = 19/75 (25%), Positives = 37/75 (49%), Gaps = 2/75 (2%) Query: 365 DEFQVTLDNKESSGVQKNFAKFIEYNLNENSFVVNNEKSNEFDSAIIQSVQGDSNLVTKK 424 D++ VT+ N E+ ++ F + + + + + + SAI++ D+ VTK+ Sbjct: 67 DDWTVTVMNDEAHDARQKFVDWQSIAAGQGNEITGGKPAEYKKSAIVRQYARDAKTVTKE 126 Query: 425 EEIYPLY--NVSSLR 437 EI L+ NV L+ Sbjct: 127 IEIKGLWPTNVGELQ 141 >1UC6-A nrPDB Length = 109 Score = 28.1 bits (61), Expect = 8.2, Method: Composition-based stats. Identities = 14/45 (31%), Positives = 23/45 (51%), Gaps = 6/45 (13%) Query: 231 FIVDKWLF-----GHKHFVSSICCGKDYLLLSAGGDDKIFAW-DW 269 I+D+W G H ++ GK+Y++ A D++I W DW Sbjct: 53 LILDQWQHVELSNGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDW 97 >4BTS-AR nrPDB Length = 343 Score = 28.1 bits (61), Expect = 8.6, Method: Compositional matrix adjust. Identities = 16/48 (33%), Positives = 23/48 (47%), Gaps = 1/48 (2%) Query: 232 IVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWDWKTGKNLSTF 278 I K L GH HFVS + ++ +S+ D + WD +TG F Sbjct: 67 IPHKALTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRF 114 >5WLC-LN nrPDB Length = 776 Score = 28.1 bits (61), Expect = 8.8, Method: Compositional matrix adjust. Identities = 15/48 (31%), Positives = 20/48 (41%), Gaps = 4/48 (8%) Query: 239 GHKHFVSSICC----GKDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNS 282 G + +C G+ L S GG + WD TG L +D NS Sbjct: 94 GKDRSIEGLCWSNVNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCNS 141 >5H72-A nrPDB Length = 82 Score = 28.1 bits (61), Expect = 9.0, Method: Composition-based stats. Identities = 14/39 (35%), Positives = 20/39 (51%) Query: 280 YNSLIKPYLNDQHLAPPRFQNENNDIIEFAVSKIIKSKN 318 YN+ I PYLN + FQ N I EF ++++ N Sbjct: 4 YNNAITPYLNKETGYQEMFQRVNTRIREFMINELKNHHN 42 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2VDU-B nrPDB 840 0.0 4V6W-Ag nrPDB 263 1e-70 3DM0-A nrPDB 241 5e-64 Sequences not found previously or not previously below threshold: 6G51-g nrPDB 228 3e-60 4V8M-A7 nrPDB 162 2e-40 5OPT-p nrPDB 159 2e-39 6HHQ-h nrPDB 136 1e-32 3JAP-g nrPDB 132 3e-31 4BTS-AR nrPDB 120 1e-27 5XYI-g nrPDB 86 3e-17 6HQA-B nrPDB 76 3e-14 5M25-A nrPDB 74 2e-13 5Y88-O nrPDB 74 2e-13 2H9P-A nrPDB 72 3e-13 5FL8-q nrPDB 69 3e-12 1VYH-C nrPDB 67 2e-11 6MZM-G nrPDB 63 3e-10 6F3T-A nrPDB 63 3e-10 5OQL-J nrPDB 63 3e-10 5NNZ-B nrPDB 63 3e-10 5GAN-H nrPDB 63 3e-10 6QX9-5O nrPDB 62 5e-10 6ID0-T nrPDB 61 9e-10 5K1B-B nrPDB 60 2e-09 5FVM-C nrPDB 60 2e-09 5WYJ-BC nrPDB 60 3e-09 4YCZ-A nrPDB 59 3e-09 5UZ7-B nrPDB 59 4e-09 1NR0-A nrPDB 59 4e-09 5NZU-C nrPDB 59 5e-09 4J0W-A nrPDB 59 6e-09 3C9C-A nrPDB 58 8e-09 3ODT-A nrPDB 57 1e-08 5WYK-BB nrPDB 57 2e-08 4A11-B nrPDB 56 3e-08 6EMK-B nrPDB 56 4e-08 6Q8F-A nrPDB 56 4e-08 4V7E-Bg nrPDB 55 7e-08 5MZH-A nrPDB 54 1e-07 3CFV-B nrPDB 54 2e-07 6QDV-o nrPDB 53 2e-07 5YZG-W nrPDB 53 2e-07 3JB9-L nrPDB 53 3e-07 5Y1U-A nrPDB 52 5e-07 6QX9-4B nrPDB 52 5e-07 4L9O-A nrPDB 52 6e-07 6EOJ-D nrPDB 52 6e-07 5OQL-L nrPDB 50 2e-06 5WJC-A nrPDB 49 5e-06 4E5Z-B nrPDB 48 7e-06 4OWR-A nrPDB 47 2e-05 4XFV-A nrPDB 46 3e-05 3JB9-g nrPDB 46 4e-05 3MKQ-A nrPDB 45 4e-05 2YNP-A nrPDB 45 4e-05 4XYI-A nrPDB 45 6e-05 4G56-B nrPDB 45 6e-05 6N9G-C nrPDB 45 8e-05 5OQL-d nrPDB 44 1e-04 6GMH-W nrPDB 44 1e-04 3BG0-A nrPDB 43 2e-04 5MWJ-A nrPDB 43 2e-04 5OQL-X nrPDB 43 3e-04 4BZK-B nrPDB 43 3e-04 3JRP-A nrPDB 43 3e-04 3JRO-A nrPDB 43 3e-04 2AQ5-A nrPDB 42 4e-04 5FA5-B nrPDB 42 4e-04 3FM0-A nrPDB 42 6e-04 6ELZ-p nrPDB 42 6e-04 6EM1-m nrPDB 42 6e-04 6CB1-s nrPDB 42 6e-04 6C0F-s nrPDB 42 6e-04 4PSX-B nrPDB 41 9e-04 5CXB-B nrPDB 41 0.001 5YZG-2 nrPDB 41 0.001 5K19-A nrPDB 41 0.001 6CHG-A nrPDB 41 0.001 2PM9-A nrPDB 41 0.001 6J6H-n nrPDB 40 0.001 5WLC-LJ nrPDB 40 0.002 6F1U-h nrPDB 39 0.003 6E29-D nrPDB 39 0.003 5TF2-A nrPDB 39 0.004 5K0Y-T nrPDB 39 0.004 5L9T-R nrPDB 39 0.005 5WBU-D nrPDB 39 0.005 5WLC-LH nrPDB 39 0.006 4AEZ-A nrPDB 38 0.008 2HES-X nrPDB 37 0.012 5BJS-A nrPDB 37 0.012 6BX3-A nrPDB 37 0.019 5WLC-LO nrPDB 37 0.022 5I2T-A nrPDB 37 0.022 5CXC-A nrPDB 36 0.026 5LCW-Q nrPDB 36 0.028 5G04-R nrPDB 36 0.028 4N14-A nrPDB 36 0.028 4GGA-A nrPDB 36 0.028 4U1E-I nrPDB 36 0.041 5A9Q-7 nrPDB 34 0.10 3F3P-A nrPDB 34 0.12 5Z56-q nrPDB 34 0.14 4LG8-A nrPDB 34 0.14 1PI6-A nrPDB 34 0.15 3W15-A nrPDB 33 0.26 5MC6-j nrPDB 32 0.40 5A31-R nrPDB 32 0.51 4BH6-A nrPDB 32 0.51 5WLC-LU nrPDB 32 0.54 2P9P-C nrPDB 32 0.79 5LTD-A nrPDB 31 0.97 3JZG-A nrPDB 31 1.2 3EI3-B nrPDB 31 1.4 5WYJ-BE nrPDB 30 1.7 5TOS-A nrPDB 29 3.1 5W5F-A nrPDB 29 3.2 2I3T-A nrPDB 29 3.7 3HK0-A nrPDB 29 4.0 4NC4-A nrPDB 29 4.6 5WLC-LN nrPDB 29 4.8 4V1Z-A nrPDB 28 7.4 >2VDU-B nrPDB Length = 450 Score = 840 bits (2171), Expect = 0.0, Method: Composition-based stats. Identities = 444/444 (100%), Positives = 444/444 (100%) Query: 1 MSVIHPLQNLLTSRDGSLVFAIIKNCILSFKYQSPNHWEFAGKWSDDFDKIQESRNTTAK 60 MSVIHPLQNLLTSRDGSLVFAIIKNCILSFKYQSPNHWEFAGKWSDDFDKIQESRNTTAK Sbjct: 1 MSVIHPLQNLLTSRDGSLVFAIIKNCILSFKYQSPNHWEFAGKWSDDFDKIQESRNTTAK 60 Query: 61 EQQGQSSENENENKKLKSNKGDSIKRTAAKVPSPGLGAPPIYSYIRNLRLTSDESRLIAC 120 EQQGQSSENENENKKLKSNKGDSIKRTAAKVPSPGLGAPPIYSYIRNLRLTSDESRLIAC Sbjct: 61 EQQGQSSENENENKKLKSNKGDSIKRTAAKVPSPGLGAPPIYSYIRNLRLTSDESRLIAC 120 Query: 121 ADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFGDVYSIDINS 180 ADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFGDVYSIDINS Sbjct: 121 ADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFGDVYSIDINS 180 Query: 181 IPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGH 240 IPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGH Sbjct: 181 IPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGH 240 Query: 241 KHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAPPRFQN 300 KHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAPPRFQN Sbjct: 241 KHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAPPRFQN 300 Query: 301 ENNDIIEFAVSKIIKSKNLPFVAFFVEATKCIIILEMSEKQKGDLALKQIITFPYNVISL 360 ENNDIIEFAVSKIIKSKNLPFVAFFVEATKCIIILEMSEKQKGDLALKQIITFPYNVISL Sbjct: 301 ENNDIIEFAVSKIIKSKNLPFVAFFVEATKCIIILEMSEKQKGDLALKQIITFPYNVISL 360 Query: 361 SAHNDEFQVTLDNKESSGVQKNFAKFIEYNLNENSFVVNNEKSNEFDSAIIQSVQGDSNL 420 SAHNDEFQVTLDNKESSGVQKNFAKFIEYNLNENSFVVNNEKSNEFDSAIIQSVQGDSNL Sbjct: 361 SAHNDEFQVTLDNKESSGVQKNFAKFIEYNLNENSFVVNNEKSNEFDSAIIQSVQGDSNL 420 Query: 421 VTKKEEIYPLYNVSSLRKHGEHYS 444 VTKKEEIYPLYNVSSLRKHGEHYS Sbjct: 421 VTKKEEIYPLYNVSSLRKHGEHYS 444 >4V6W-Ag nrPDB Length = 318 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 48/200 (24%), Positives = 96/200 (48%), Gaps = 23/200 (11%) Query: 104 YIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRF-CFSKRPNAISIAEDDT 162 +I ++ L+SD + ++ D++L ++D+ K +RF +K +++ + D+ Sbjct: 66 FISDVVLSSDGNYALS-GSWDQTLRLWDLAAG-----KTTRRFEGHTKDVLSVAFSADNR 119 Query: 163 TVIIA--DKFGDVYSIDINSIPEEKFT-QEPILGHVSMLTDVHLIKDSDGHQFIITSDRD 219 ++ DK ++ N++ E KFT QE GH ++ V + + I++ D Sbjct: 120 QIVSGSRDKTIKLW----NTLAECKFTIQED--GHTDWVSCVRF-SPNHSNPIIVSCGWD 172 Query: 220 EHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDD-KIFAWDWKTGKNLSTF 278 +K+ + C + + GH +++++ D L ++GG D K WD GKNL T Sbjct: 173 RTVKVWNLANCKLKNN-HHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTL 231 Query: 279 DYNSLIKPYLNDQHLAPPRF 298 ++N +I N +P R+ Sbjct: 232 EHNDII----NALCFSPNRY 247 Score = 58.6 bits (140), Expect = 5e-09, Method: Composition-based stats. Identities = 22/95 (23%), Positives = 38/95 (40%), Gaps = 8/95 (8%) Query: 191 ILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYP-----QCFIVDKWLFGHKHFVS 245 ++GH +T + + II++ RD+ + + K L+GH HF+S Sbjct: 11 LIGHNGWVT--QIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFIS 68 Query: 246 SICCGKDYLLLSAGGDDKIF-AWDWKTGKNLSTFD 279 + D +G D+ WD GK F+ Sbjct: 69 DVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFE 103 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 24/113 (21%), Positives = 47/113 (41%), Gaps = 7/113 (6%) Query: 159 EDDTTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITS 216 +D T+I A DK V+ + + + Q+ + GH ++DV L D + + ++ Sbjct: 26 KDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVLSSDGN---YALSG 82 Query: 217 DRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIF-AWD 268 D+ +++ + GH V S+ D + +G DK W+ Sbjct: 83 SWDQTLRLWDLAAGK-TTRRFEGHTKDVLSVAFSADNRQIVSGSRDKTIKLWN 134 >3DM0-A nrPDB Length = 694 Score = 241 bits (615), Expect = 5e-64, Method: Composition-based stats. Identities = 43/199 (21%), Positives = 93/199 (46%), Gaps = 19/199 (9%) Query: 104 YIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTT 163 ++ ++ L+SD ++ D L ++D+ + R+ +K +++ + D+ Sbjct: 432 FVEDVVLSSDGQFALS-GSWDGELRLWDLAAG----VSTRRFVGHTKDVLSVAFSLDNRQ 486 Query: 164 VIIA--DKFGDVYSIDINSIPEEKFT-QEPILGHVSMLTDVHLIKDSDGHQFIITSDRDE 220 ++ A D+ ++ N++ E K+T E GH ++ V ++ I+++ D+ Sbjct: 487 IVSASRDRTIKLW----NTLGECKYTISEGGEGHRDWVSCVRFSPNTL-QPTIVSASWDK 541 Query: 221 HIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDK-IFAWDWKTGKNLSTFD 279 +K+ + C + L GH +VS++ D L ++GG D + WD GK L + + Sbjct: 542 TVKVWNLSNCKLRST-LAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLE 600 Query: 280 YNSLIKPYLNDQHLAPPRF 298 NS+I + +P R+ Sbjct: 601 ANSVI----HALCFSPNRY 615 Score = 52.8 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 20/85 (23%), Positives = 32/85 (37%), Gaps = 7/85 (8%) Query: 193 GHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQ----CFIVDKWLFGHKHFVSSIC 248 H M+T + D I+++ RD+ I + + + + L GH HFV + Sbjct: 380 AHTDMVTAI--ATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVV 437 Query: 249 CGKDYLLLSAGGDDKIF-AWDWKTG 272 D +G D WD G Sbjct: 438 LSSDGQFALSGSWDGELRLWDLAAG 462 >6G51-g nrPDB Length = 317 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 39/199 (19%), Positives = 89/199 (44%), Gaps = 21/199 (10%) Query: 104 YIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRF-CFSKRPNAISIAEDDT 162 ++ ++ ++SD ++ D +L ++D+ + +RF +K +++ + D+ Sbjct: 65 FVSDVVISSDGQFALS-GSWDGTLRLWDLTTGT-----TTRRFVGHTKDVLSVAFSSDNR 118 Query: 163 TVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDE 220 ++ DK ++ N++ K+T + H ++ V +S + I++ D+ Sbjct: 119 QIVSGSRDKTIKLW----NTLGVCKYTVQD-ESHSEWVSCVRFSPNS-SNPIIVSCGWDK 172 Query: 221 HIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDK-IFAWDWKTGKNLSTFD 279 +K+ + C + GH +++++ D L ++GG D WD GK+L T D Sbjct: 173 LVKVWNLANCKLKTN-HIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231 Query: 280 YNSLIKPYLNDQHLAPPRF 298 +I N +P R+ Sbjct: 232 GGDII----NALCFSPNRY 246 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 31/131 (23%), Positives = 48/131 (36%), Gaps = 15/131 (11%) Query: 193 GHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYP----QCFIVDKWLFGHKHFVSSIC 248 GH +T + I+++ RD+ I + I + L GH HFVS + Sbjct: 13 GHNGWVTQIATTP--QFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 Query: 249 CGKDYLLLSAGGDDKIF-AWDWKTGKNLSTFDYNSLIKPYLNDQHLAPPRFQNENNDIIE 307 D +G D WD TG F + + +A F ++N I+ Sbjct: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRF-----VGHTKDVLSVA---FSSDNRQIVS 122 Query: 308 FAVSKIIKSKN 318 + K IK N Sbjct: 123 GSRDKTIKLWN 133 Score = 28.2 bits (61), Expect = 8.5, Method: Composition-based stats. Identities = 12/49 (24%), Positives = 19/49 (38%), Gaps = 2/49 (4%) Query: 237 LFGHKHFVSSICCGKDY--LLLSAGGDDKIFAWDWKTGKNLSTFDYNSL 283 L GH +V+ I + ++LSA D I W + +L Sbjct: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRAL 59 >4V8M-A7 nrPDB Length = 318 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 37/199 (18%), Positives = 79/199 (39%), Gaps = 19/199 (9%) Query: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDT 162 +++ ++ L+++ + ++ A D SL ++++ K +K +++ + D+ Sbjct: 68 AFVSDVALSNNGNFAVS-ASWDHSLRLWNLQNGQCQY----KFLGHTKDVLSVAFSPDNR 122 Query: 163 TVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDE 220 ++ D V+ N E T H ++ V S I++ D Sbjct: 123 QIVSGGRDNALRVW----NVKGECMHTLSRG-AHTDWVSCVRF-SPSLDAPVIVSGGWDN 176 Query: 221 HIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIF-AWDWKTGKNLSTFD 279 +K+ +V L GH ++V+S+ D L ++ D + WD G+ LS Sbjct: 177 LVKVWDLATGRLV-TDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMA 235 Query: 280 YNSLIKPYLNDQHLAPPRF 298 + I N +P R+ Sbjct: 236 AGAPI----NQICFSPNRY 250 Score = 49.0 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 20/95 (21%), Positives = 40/95 (42%), Gaps = 9/95 (9%) Query: 193 GHVSMLTDVHLIKDSDGHQFIITSDRDEHIKIS------HYPQCF--IVDKWLFGHKHFV 244 GH +T + + + ++++ RD+ + H +C + D+ L GH FV Sbjct: 11 GHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFV 70 Query: 245 SSICCGKDYLL-LSAGGDDKIFAWDWKTGKNLSTF 278 S + + +SA D + W+ + G+ F Sbjct: 71 SDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKF 105 >5OPT-p nrPDB Length = 318 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 45/235 (19%), Positives = 89/235 (37%), Gaps = 33/235 (14%) Query: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDT 162 +++ ++ L+++ ++ A D SL ++++ K +K +++ + D+ Sbjct: 68 AFVSDVALSNNGDFAVS-ASWDHSLRLWNLQTGVCQ----HKFLGHTKDVLSVTFSPDNR 122 Query: 163 TVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDE 220 ++ D V+ N E T H ++ V S I++ D Sbjct: 123 QIVSGGRDNALRVW----NVKGECLHTL-GRGAHTDWVSCVRF-SPSLETPLIVSGGWDN 176 Query: 221 HIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIF-AWDWKTGKNLSTFD 279 +K+ ++ L GH ++++S+ D L ++ D + WD G+ LS Sbjct: 177 LVKVWDIASGRLL-TDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMA 235 Query: 280 YNSLIKPYLNDQHLAPPRF-------------QNENND-IIEFAVSKIIKSKNLP 320 + I N +P R+ EN D I+E A KSK P Sbjct: 236 AGAPI----NQICFSPNRYWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKKTP 286 Score = 62.8 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 32/128 (25%), Positives = 58/128 (45%), Gaps = 15/128 (11%) Query: 154 AISIAEDDTTVIIADKFGDVYSIDINSIPEEK--FTQEPILGHVSMLTDVHLIKDSDGHQ 211 A+S + D+T + ++D NS E + F + + GH + ++DV L + D Sbjct: 31 AVSTSRDNTLIAWGS------NMDRNS-EECEYGFPERRLEGHSAFVSDVALSNNGD--- 80 Query: 212 FIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIF-AWDWK 270 F +++ D +++ + K+L GH V S+ D + +GG D W+ K Sbjct: 81 FAVSASWDHSLRLWNLQTGVCQHKFL-GHTKDVLSVTFSPDNRQIVSGGRDNALRVWNVK 139 Query: 271 TGKNLSTF 278 G+ L T Sbjct: 140 -GECLHTL 146 Score = 41.3 bits (95), Expect = 8e-04, Method: Composition-based stats. Identities = 18/89 (20%), Positives = 38/89 (42%), Gaps = 9/89 (10%) Query: 193 GHVSMLTDVHLIKDSDGHQFIITSDRDEHIKIS------HYPQCF--IVDKWLFGHKHFV 244 GH +T + + ++ + +++ RD + + +C ++ L GH FV Sbjct: 11 GHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFV 70 Query: 245 SSICCGKDYLL-LSAGGDDKIFAWDWKTG 272 S + + +SA D + W+ +TG Sbjct: 71 SDVALSNNGDFAVSASWDHSLRLWNLQTG 99 >6HHQ-h nrPDB Length = 319 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 43/212 (20%), Positives = 90/212 (42%), Gaps = 31/212 (14%) Query: 100 PIYSY------IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRF-CFSKRP 152 P+ S+ +++ LT+D + ++ A DK+L ++DV + +RF Sbjct: 57 PVRSFKGHSHIVQDCTLTADGAYALS-ASWDKTLRLWDVATG-----ETYQRFVGHKSDV 110 Query: 153 NAISIAEDDTTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKD---S 207 ++ I + + +I DK V++I + T +LGH ++ V ++ + Sbjct: 111 MSVDIDKKASMIISGSRDKTIKVWTIK----GQCLAT---LLGHNDWVSQVRVVPNEKAD 163 Query: 208 DGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDK-IFA 266 D II++ D+ +K + Q I ++ GH ++++ D L+++ G D I Sbjct: 164 DDSVTIISAGNDKMVKAWNLNQFQIEADFI-GHNSNINTLTASPDGTLIASAGKDGEIML 222 Query: 267 WDWKTGKNLSTFDYNSLIKPYLNDQHLAPPRF 298 W+ K + T + +P R+ Sbjct: 223 WNLAAKKAMYTLSAQDEVF----SLAFSPNRY 250 >3JAP-g nrPDB Length = 326 Score = 132 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 37/216 (17%), Positives = 91/216 (42%), Gaps = 33/216 (15%) Query: 100 PIYSY------IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPN 153 P+ SY ++++ +++D + ++ A DK+L ++++ + + + Sbjct: 58 PVRSYKGHSHIVQDVVVSADGNYAVS-ASWDKTLRLWNLATGNSEA----RFVGHTGDVL 112 Query: 154 AISIAEDDTTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDS---- 207 +++I + + +I A DK V+ N++ + + +LGH +T V + + Sbjct: 113 SVAIDANSSKIISASRDKTIRVW----NTVGDCAYV---LLGHTDWVTKVRVAPKNLEDG 165 Query: 208 ---DGHQFIITSDRDEHIKISHY-PQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDK 263 DG +++ D+ ++ + ++ GH ++++ + D L ++ G D Sbjct: 166 EVDDGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDG 225 Query: 264 -IFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAPPRF 298 I+ W+ K FD + +P RF Sbjct: 226 QIYVWNLKHKSAFMNFDAKDEVF----ALAFSPSRF 257 >4BTS-AR nrPDB Length = 343 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 35/204 (17%), Positives = 75/204 (36%), Gaps = 28/204 (13%) Query: 104 YIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRF-CFSKRPNAISIAEDDT 162 ++ +L L+ + I+ + DK+L ++D+ + KRF +++ + D+ Sbjct: 78 FVSDLALSQENCFAIS-SSWDKTLRLWDLRTGT-----TYKRFVGHQSEVYSVAFSPDNR 131 Query: 163 TVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDG-------HQFI 213 ++ A ++ ++ N + E KF+ H ++ V + Sbjct: 132 QILSAGAEREIKLW----NILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYF 187 Query: 214 ITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDD-KIFAWD-WKT 271 + D +K+ + I + H+ V+ + + ++ GG D K+ WD Sbjct: 188 ASVGWDGRLKVWN-TNFQIRYTFKA-HESNVNHLSISPNGKYIATGGKDKKLLIWDILNL 245 Query: 272 GKNLSTFDYNSLIKPYLNDQHLAP 295 FD S I N P Sbjct: 246 TYPQREFDAGSTI----NQIAFNP 265 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 23/92 (25%), Positives = 39/92 (42%), Gaps = 10/92 (10%) Query: 191 ILGHVSMLTDV---HLIKDSDGHQFIITSDRDEHIKISHYPQCF------IVDKWLFGHK 241 + GH +T + K+++ +I+ RD+ + I + I K L GH Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHN 76 Query: 242 HFVSSICCGKDYLLLSAGGDDKIF-AWDWKTG 272 HFVS + ++ + DK WD +TG Sbjct: 77 HFVSDLALSQENCFAISSSWDKTLRLWDLRTG 108 >5XYI-g nrPDB Length = 335 Score = 85.9 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 44/231 (19%), Positives = 83/231 (35%), Gaps = 28/231 (12%) Query: 65 QSSENENENKKLKSNKGDS------IKRTAAKVPSPGLGAPPIYSYIRNLRLTSDESRLI 118 +S E +NE+ L S D + RT + +P ++ ++ L+ D S L+ Sbjct: 37 ESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLSRDASHLL 96 Query: 119 ACADSDKSLLVFDVDKTSKNVLKLRKRF--CFSKRPNAISIAEDDTTVIIA--DKFGDVY 174 + D +L ++D+ + K+ K ++ + + +I D ++ Sbjct: 97 T-SSWDSTLRLWDLST------RTTKKLFLGHKKDVLGVTFSPCNRRIISVGRDNQVKIW 149 Query: 175 SIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSD-GHQFIITSD-RDEHIKISHYPQCFI 232 N + E K L S +T V +D +I D + I + Sbjct: 150 ----NILGENK----AELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEAK 201 Query: 233 VDKWLFGHKHFVSSICCGKDYLLLSAGGDD-KIFAWDWKTGKNLSTFDYNS 282 + K H +S+ D + GG D K+ W + G +F S Sbjct: 202 LIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTAPS 252 Score = 47.8 bits (112), Expect = 9e-06, Method: Composition-based stats. Identities = 31/144 (21%), Positives = 63/144 (43%), Gaps = 15/144 (10%) Query: 147 CFSKRPNAISIAEDDTTVIIA--DKFGDVYSIDINSIPEE---KFTQEPILGHVSMLTDV 201 + +I I + ++ A DK V+ + N E+ FT+ ++GH ++DV Sbjct: 31 GHNAAIESIEIDNEHNYLVSASRDKSALVWKL--NRTQEQWATPFTR--LIGHNHFVSDV 86 Query: 202 HLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGK-DYLLLSAGG 260 L +D+ ++TS D +++ K GHK V + + ++S G Sbjct: 87 SLSRDASH---LLTSSWDSTLRLWDLST-RTTKKLFLGHKKDVLGVTFSPCNRRIISVGR 142 Query: 261 DDKIFAWDWKTGKNLSTFDYNSLI 284 D+++ W+ G+N + +S + Sbjct: 143 DNQVKIWNI-LGENKAELQCSSWV 165 >6HQA-B nrPDB Length = 722 Score = 75.9 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 30/174 (17%), Positives = 65/174 (37%), Gaps = 18/174 (10%) Query: 108 LRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA 167 + + D LI+C DK++ ++ +D + V S + + A Sbjct: 459 VDFSPDNRYLISC-SEDKTVRLWSLDTYTCLVSYK----GHSSSVWDVKFSPMGHYFATA 513 Query: 168 --DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKIS 225 D+ ++S D + GH++ + V +S ++ T D+ ++ Sbjct: 514 SHDQTARLWSCDH------IYPLRIFAGHLNDVDCVEFHPNS---TYLFTGSSDKTARMW 564 Query: 226 HYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIF-AWDWKTGKNLSTF 278 + V + GH ++ + D L++ G+D + WD TG+ + Sbjct: 565 DIARGECV-RVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAM 617 Score = 57.4 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 28/176 (15%), Positives = 65/176 (36%), Gaps = 19/176 (10%) Query: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDT 162 S + +++ + A A D++ ++ D ++ LR + + + T Sbjct: 496 SSVWDVKFSPMGHY-FATASHDQTARLWSCD----HIYPLRIFAGHLNDVDCVEFHPNST 550 Query: 163 TVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDE 220 + DK ++ I E +GH + + + D +++ ++ D Sbjct: 551 YLFTGSSDKTARMWDIAR---GECVRV---FMGHSGAINCLAVSPDG---RWLASAGEDS 601 Query: 221 HIKISHYPQCFIVDKWLFGH-KHFVSSICCGKDYL-LLSAGGDDKIFAWDWKTGKN 274 + + K + GH + + S+ ++ L+S G D+ + WD K N Sbjct: 602 VVCLWDISTGR-RIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVKKNTN 656 Score = 45.9 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 23/139 (16%), Positives = 48/139 (34%), Gaps = 26/139 (18%) Query: 149 SKRPNAISIAEDDTTVIIA--DKFGDVYSIDINS----IPEEKFTQEP-----------I 191 + + +D T V D F ++SID + + + + Q+ + Sbjct: 390 NNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRL 449 Query: 192 LGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYP--QCFIVDKWLFGHKHFVSSICC 249 +GH + V D ++++I+ D+ +++ C + K GH V + Sbjct: 450 VGHSGAVYGVDFSPD---NRYLISCSEDKTVRLWSLDTYTCLVSYK---GHSSSVWDVKF 503 Query: 250 GKDY-LLLSAGGDDKIFAW 267 +A D W Sbjct: 504 SPMGHYFATASHDQTARLW 522 >5M25-A nrPDB Length = 434 Score = 73.6 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 35/177 (19%), Positives = 70/177 (39%), Gaps = 17/177 (9%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 I ++ +SD + L++ +D DK+L ++DV LK K S + + Sbjct: 190 ISDVAWSSDSNLLVSASD-DKTLKIWDVSSG--KCLKTLK--GHSNYVFCCNFNPQSNLI 244 Query: 165 IIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHI 222 + D+ ++ + + T + H ++ VH +D I++S D Sbjct: 245 VSGSFDESVRIWDVKT---GKCLKT---LPAHSDPVSAVHFNRDG---SLIVSSSYDGLC 295 Query: 223 KISHYPQCFIVDKWLFGHKHFVSSICCGKDYL-LLSAGGDDKIFAWDWKTGKNLSTF 278 +I + + VS + + +L+A D+ + WD+ GK L T+ Sbjct: 296 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 352 Score = 69.0 bits (167), Expect = 4e-12, Method: Composition-based stats. Identities = 33/139 (23%), Positives = 62/139 (44%), Gaps = 13/139 (9%) Query: 147 CFSKRPNAISIAEDDTTVII--ADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLI 204 +K +++ + + + ADK ++ + KF ++ I GH ++DV Sbjct: 143 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY-----DGKF-EKTISGHKLGISDVAWS 196 Query: 205 KDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG-DDK 263 DS+ ++++ D+ +KI + K L GH ++V L+ +G D+ Sbjct: 197 SDSN---LLVSASDDKTLKIWDVSSGKCL-KTLKGHSNYVFCCNFNPQSNLIVSGSFDES 252 Query: 264 IFAWDWKTGKNLSTFDYNS 282 + WD KTGK L T +S Sbjct: 253 VRIWDVKTGKCLKTLPAHS 271 Score = 57.0 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 29/99 (29%), Positives = 45/99 (45%), Gaps = 8/99 (8%) Query: 185 KFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFV 244 KFT + GH ++ V + +++ +S D+ IKI +K + GHK + Sbjct: 138 KFT---LAGHTKAVSSVKFSPNG---EWLASSSADKLIKIWGAYDGKF-EKTISGHKLGI 190 Query: 245 SSICCGKDYLLLSAGGDDKIF-AWDWKTGKNLSTFDYNS 282 S + D LL + DDK WD +GK L T +S Sbjct: 191 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHS 229 Score = 47.4 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 30/169 (17%), Positives = 57/169 (33%), Gaps = 18/169 (10%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNA-ISIAEDDTT 163 + + D S LI + D ++D L+ P + + + + Sbjct: 274 VSAVHFNRDGS-LIVSSSYDGLCRIWDTASGQC----LKTLIDDDNPPVSFVKFSPNGKY 328 Query: 164 VIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEH 221 ++ A D ++ S + T GH + + G ++I++ D Sbjct: 329 ILAATLDNTLKLWDY---SKGKCLKT---YTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 382 Query: 222 IKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG---DDKIFAW 267 + I + IV K L GH V S C ++++ D I W Sbjct: 383 VYIWNLQTKEIVQK-LQGHTDVVISTACHPTENIIASAALENDKTIKLW 430 >5Y88-O nrPDB Length = 451 Score = 73.6 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 38/198 (19%), Positives = 78/198 (39%), Gaps = 20/198 (10%) Query: 104 YIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTT 163 ++R + + ++ +D ++ V+D+ LK +++++ Sbjct: 141 WVRCVAIDPVDNEWFITGSNDTTMKVWDLATGK---LKTTLA-GHVMTVRDVAVSDRHPY 196 Query: 164 V--IIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEH 221 + + DK + ++ N I + + GH+S + V + D I T+ RD Sbjct: 197 LFSVSEDKTVKCWDLEKNQIIRDYY------GHLSGVRTVSIHPTLD---LIATAGRDSV 247 Query: 222 IKISHYPQCFIVDKWLFGHKHFVSSICCGK-DYLLLSAGGDDKIFAWDWKTGKNLSTFDY 280 IK+ + I L GHK ++ + C D ++S+ D + WD GK + + Sbjct: 248 IKLWDM-RTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTH 306 Query: 281 NSLIKPYLNDQHLAPPRF 298 + K + L P F Sbjct: 307 H---KRSVRATALHPKEF 321 Score = 52.4 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 27/177 (15%), Positives = 63/177 (35%), Gaps = 17/177 (9%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 +R++ ++ L + DK++ +D++K +R + +SI + Sbjct: 185 VRDVAVSDRHPYLFSV-SEDKTVKCWDLEKNQI----IRDYYGHLSGVRTVSIHPTLDLI 239 Query: 165 IIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHI 222 A D ++ + + ++GH + V +++S D + Sbjct: 240 ATAGRDSVIKLWDMRT------RIPVITLVGHKGPINQVQCTP---VDPQVVSSSTDATV 290 Query: 223 KISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFD 279 ++ + K L HK V + +++ D I +W G L+ F+ Sbjct: 291 RLWDVVAGKTM-KVLTHHKRSVRATALHPKEFSVASACTDDIRSWGLAEGSLLTNFE 346 >2H9P-A nrPDB Length = 329 Score = 72.5 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 35/177 (19%), Positives = 70/177 (39%), Gaps = 17/177 (9%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 I ++ +SD + L++ +D DK+L ++DV LK K S + + Sbjct: 85 ISDVAWSSDSNLLVSASD-DKTLKIWDVSSG--KCLKTLK--GHSNYVFCCNFNPQSNLI 139 Query: 165 IIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHI 222 + D+ ++ + + T + H ++ VH +D I++S D Sbjct: 140 VSGSFDESVRIWDVKT---GKCLKT---LPAHSDPVSAVHFNRDG---SLIVSSSYDGLC 190 Query: 223 KISHYPQCFIVDKWLFGHKHFVSSICCGKDYL-LLSAGGDDKIFAWDWKTGKNLSTF 278 +I + + VS + + +L+A D+ + WD+ GK L T+ Sbjct: 191 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 247 Score = 67.8 bits (164), Expect = 9e-12, Method: Composition-based stats. Identities = 33/139 (23%), Positives = 62/139 (44%), Gaps = 13/139 (9%) Query: 147 CFSKRPNAISIAEDDTTVII--ADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLI 204 +K +++ + + + ADK ++ + KF ++ I GH ++DV Sbjct: 38 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY-----DGKF-EKTISGHKLGISDVAWS 91 Query: 205 KDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG-DDK 263 DS+ ++++ D+ +KI + K L GH ++V L+ +G D+ Sbjct: 92 SDSN---LLVSASDDKTLKIWDVSSGKCL-KTLKGHSNYVFCCNFNPQSNLIVSGSFDES 147 Query: 264 IFAWDWKTGKNLSTFDYNS 282 + WD KTGK L T +S Sbjct: 148 VRIWDVKTGKCLKTLPAHS 166 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 29/99 (29%), Positives = 45/99 (45%), Gaps = 8/99 (8%) Query: 185 KFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFV 244 KFT + GH ++ V + +++ +S D+ IKI +K + GHK + Sbjct: 33 KFT---LAGHTKAVSSVKFSPNG---EWLASSSADKLIKIWGAYDGKF-EKTISGHKLGI 85 Query: 245 SSICCGKDYLLLSAGGDDKIF-AWDWKTGKNLSTFDYNS 282 S + D LL + DDK WD +GK L T +S Sbjct: 86 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHS 124 Score = 46.6 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 30/169 (17%), Positives = 57/169 (33%), Gaps = 18/169 (10%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNA-ISIAEDDTT 163 + + D S LI + D ++D L+ P + + + + Sbjct: 169 VSAVHFNRDGS-LIVSSSYDGLCRIWDTASGQC----LKTLIDDDNPPVSFVKFSPNGKY 223 Query: 164 VIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEH 221 ++ A D ++ S + T GH + + G ++I++ D Sbjct: 224 ILAATLDNTLKLWDY---SKGKCLKT---YTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 277 Query: 222 IKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG---DDKIFAW 267 + I + IV K L GH V S C ++++ D I W Sbjct: 278 VYIWNLQTKEIVQK-LQGHTDVVISTACHPTENIIASAALENDKTIKLW 325 >5FL8-q nrPDB Length = 515 Score = 69.4 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 29/154 (18%), Positives = 64/154 (41%), Gaps = 16/154 (10%) Query: 117 LIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA--DKFGDVY 174 ++ A D ++ +++ K++K + ++ K N ++ + D ++ A D ++ Sbjct: 373 MMVTASDDYTMFLWNPLKSTKPIARMT---GHQKLVNHVAFSPDGRYIVSASFDNSIKLW 429 Query: 175 SIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVD 234 + KF GHV+ + V D + +++ +D +K+ + Sbjct: 430 DGR-----DGKFIST-FRGHVASVYQVAWSSDC---RLLVSCSKDTTLKVWDVRTRKL-S 479 Query: 235 KWLFGHKHFVSSICCGKDYLLLSAGGDDKIF-AW 267 L GHK V ++ D + +GG DK+ W Sbjct: 480 VDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 62.4 bits (150), Expect = 4e-10, Method: Composition-based stats. Identities = 31/162 (19%), Positives = 57/162 (35%), Gaps = 20/162 (12%) Query: 118 IACADSDKSLLVFDVD-KTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA--DKFGDVY 174 + D + ++D D +T + LK +S + D + D ++ Sbjct: 159 MVTGAGDNTARIWDCDTQTPMHTLK-----GHYNWVLCVSWSPDGEVIATGSMDNTIRLW 213 Query: 175 SIDINSIPEEKFTQEPILGHVSMLTD-----VHLIKDSDGHQFIITSDRDEHIKISHYPQ 229 + + + GH +T +HL+K + +S +D IKI Sbjct: 214 DPKS---GQC--LGDALRGHSKWITSLSWEPIHLVKPG-SKPRLASSSKDGTIKIWDTVS 267 Query: 230 CFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKT 271 + + GH + VS + G LL S D + WD + Sbjct: 268 -RVCQYTMSGHTNSVSCVKWGGQGLLYSGSHDRTVRVWDINS 308 Score = 60.9 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 33/187 (17%), Positives = 66/187 (35%), Gaps = 31/187 (16%) Query: 102 YSYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISI---- 157 Y+++ + + D +IA D ++ ++D LR SK ++S Sbjct: 186 YNWVLCVSWSPDGE-VIATGSMDNTIRLWDPKSGQCLGDALR---GHSKWITSLSWEPIH 241 Query: 158 -----AEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQF 212 ++ D ++ ++T + GH + ++ V G Sbjct: 242 LVKPGSKPRLASSSKDGTIKIWDTVSRV---CQYT---MSGHTNSVSCVKWG----GQGL 291 Query: 213 IITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKTG 272 + + D +++ L H H+V+ + DY L +I A+D TG Sbjct: 292 LYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYAL-------RIGAFD-HTG 343 Query: 273 KNLSTFD 279 K ST + Sbjct: 344 KKPSTPE 350 Score = 55.9 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 36/167 (21%), Positives = 72/167 (43%), Gaps = 16/167 (9%) Query: 114 ESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA-DKFGD 172 L+ D+++ V+D++ + + L+ + N +S++ D I A D G Sbjct: 288 GQGLLYSGSHDRTVRVWDINSQGRCINILKS---HAHWVNHLSLSTDYALRIGAFDHTGK 344 Query: 173 VYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFI 232 S PEE Q+ L + + K+ + + ++T+ D + + + + Sbjct: 345 -----KPSTPEE--AQKKALENYEKIC----KKNGNSEEMMVTASDDYTMFLWNPLKSTK 393 Query: 233 VDKWLFGHKHFVSSICCGKDYL-LLSAGGDDKIFAWDWKTGKNLSTF 278 + GH+ V+ + D ++SA D+ I WD + GK +STF Sbjct: 394 PIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFISTF 440 >1VYH-C nrPDB Length = 410 Score = 66.7 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 31/199 (15%), Positives = 68/199 (34%), Gaps = 42/199 (21%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 ++++ L +C +D ++ ++D + +R +++SI + + Sbjct: 153 VQDISFDHSGKLLASC-SADMTIKLWDF----QGFECIRTMHGHDHNVSSVSIMPNGDHI 207 Query: 165 IIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHI 222 + A DK ++ + + + + GH V +++ + I + D+ + Sbjct: 208 VSASRDKTIKMWEV------QTGYCVKTFTGHREW---VRMVRPNQDGTLIASCSNDQTV 258 Query: 223 KISHYP--QCFIVDKWLFGHKHFVSSICCGKD--------------------YLLLSAGG 260 ++ +C L H+H V I + L +G Sbjct: 259 RVWVVATKECK---AELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGS 315 Query: 261 DDKIF-AWDWKTGKNLSTF 278 DK WD TG L T Sbjct: 316 RDKTIKMWDVSTGMCLMTL 334 Score = 57.0 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 40/184 (21%), Positives = 75/184 (40%), Gaps = 30/184 (16%) Query: 104 YIRNLRLTSDESRLIACADSDKSLLVFDVD-KTSKNVLKLRKRF--CFSKRP----NAIS 156 ++R +R D + + +C +D+++ V+ V K K L+ + C S P ++IS Sbjct: 236 WVRMVRPNQDGTLIASC-SNDQTVRVWVVATKECKAELREHRHVVECISWAPESSYSSIS 294 Query: 157 IAEDDTTVIIA-----------DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIK 205 A T DK ++ + S T ++GH + + V Sbjct: 295 EATGSETKKSGKPGPFLLSGSRDKTIKMWDV---STGMCLMT---LVGHDNWVRGVLFHS 348 Query: 206 DSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG-DDKI 264 G +FI++ D+ +++ Y K L H+HFV+S+ K + G D + Sbjct: 349 ---GGKFILSCADDKTLRVWDYKN-KRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTV 404 Query: 265 FAWD 268 W+ Sbjct: 405 KVWE 408 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 29/117 (24%), Positives = 46/117 (39%), Gaps = 12/117 (10%) Query: 182 PEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHK 241 P EK+ + GH S +T V ++++ D IK+ Y L GH Sbjct: 98 PPEKYA---LSGHRSPVTRVIFHP---VFSVMVSASEDATIKVWDYETGDFERT-LKGHT 150 Query: 242 HFVSSICCGKDYLLLSA-GGDDKIFAWDWKTGKNLSTF---DYN-SLIKPYLNDQHL 293 V I LL++ D I WD++ + + T D+N S + N H+ Sbjct: 151 DSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHI 207 >6MZM-G nrPDB Length = 800 Score = 62.8 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 26/176 (14%), Positives = 62/176 (35%), Gaps = 22/176 (12%) Query: 100 PIYSYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAE 159 P+Y + D + L++ + D ++ ++ + + V + + Sbjct: 545 PVYG----ASFSPDRNYLLS-SSEDGTVRLWSLQTFTCLVGYK----GHNYPVWDTQFSP 595 Query: 160 DDTTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSD 217 + D+ +++ D + P F GH++ + +S+ ++ T Sbjct: 596 YGYYFVSGGHDRVARLWATD-HYQPLRIFA-----GHLADVNCTRFHPNSN---YVATGS 646 Query: 218 RDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDK-IFAWDWKTG 272 D +++ V + GHK + S+ + L+ G D + WD G Sbjct: 647 ADRTVRLWDVLNGNCV-RIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701 Score = 47.0 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 36/213 (16%), Positives = 78/213 (36%), Gaps = 22/213 (10%) Query: 107 NLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVI- 165 + + + ++ D+ ++ D + LR N + V Sbjct: 590 DTQFSPYGYYFVSGGH-DRVARLWATD----HYQPLRIFAGHLADVNCTRFHPNSNYVAT 644 Query: 166 -IADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI 224 AD+ ++ + +N FT GH + + + +F+ T D + + Sbjct: 645 GSADRTVRLWDV-LNGNCVRIFT-----GHKGPIHSLTFSPNG---RFLATGATDGRVLL 695 Query: 225 SHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG-DDKIFAWD-WKTGKNLSTFDYNS 282 +V + L GH V S+ +D +L++G D+ + WD K ++L T D+ + Sbjct: 696 WDIGHGLMVGE-LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTT 754 Query: 283 L---IKPYLNDQHLAPPRFQNENNDIIEFAVSK 312 I N Q L + ++ ++ ++ Sbjct: 755 ATGHINLPENSQELLLGTYMTKSTPVVHLHFTR 787 >6F3T-A nrPDB Length = 608 Score = 62.8 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 26/176 (14%), Positives = 62/176 (35%), Gaps = 22/176 (12%) Query: 100 PIYSYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAE 159 P+Y + D + L++ + D ++ ++ + + V + + Sbjct: 353 PVYG----ASFSPDRNYLLS-SSEDGTVRLWSLQTFTCLVGYK----GHNYPVWDTQFSP 403 Query: 160 DDTTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSD 217 + D+ +++ D + P F GH++ + +S+ ++ T Sbjct: 404 YGYYFVSGGHDRVARLWATD-HYQPLRIFA-----GHLADVNCTRFHPNSN---YVATGS 454 Query: 218 RDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDK-IFAWDWKTG 272 D +++ V + GHK + S+ + L+ G D + WD G Sbjct: 455 ADRTVRLWDVLNGNCV-RIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 509 Score = 47.0 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 36/213 (16%), Positives = 78/213 (36%), Gaps = 22/213 (10%) Query: 107 NLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVI- 165 + + + ++ D+ ++ D + LR N + V Sbjct: 398 DTQFSPYGYYFVSGGH-DRVARLWATD----HYQPLRIFAGHLADVNCTRFHPNSNYVAT 452 Query: 166 -IADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI 224 AD+ ++ + +N FT GH + + + +F+ T D + + Sbjct: 453 GSADRTVRLWDV-LNGNCVRIFT-----GHKGPIHSLTFSPNG---RFLATGATDGRVLL 503 Query: 225 SHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG-DDKIFAWD-WKTGKNLSTFDYNS 282 +V + L GH V S+ +D +L++G D+ + WD K ++L T D+ + Sbjct: 504 WDIGHGLMVGE-LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTT 562 Query: 283 L---IKPYLNDQHLAPPRFQNENNDIIEFAVSK 312 I N Q L + ++ ++ ++ Sbjct: 563 ATGHINLPENSQELLLGTYMTKSTPVVHLHFTR 595 >5OQL-J nrPDB Length = 912 Score = 62.8 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 45/211 (21%), Positives = 75/211 (35%), Gaps = 36/211 (17%) Query: 99 PPIYSYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLR---KRFCFSKRPNAI 155 PP S L + LI+ D+ + D+ + + KL +R K NA+ Sbjct: 492 PPANSEAFKNPLDHPPAFLIS-GSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINAL 550 Query: 156 SIAEDDTTVIIA--DKFGDVYSIDINSIPEEKFTQEPIL-GHVSMLTDVHLIKDS----- 207 I+ + A DK ++ + EK + IL GH + V + Sbjct: 551 DISPNGKLFASASQDKTVKIWDV-------EKLEVQGILRGHKRGVWTVRFAPLNTPVIQ 603 Query: 208 ------DGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSIC---CGKDYLL--- 255 G ++T D+ IK+ + + + GH H V + +D + Sbjct: 604 GEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTF-EGHSHNVLKVVWLHISRDDSITKT 662 Query: 256 ----LSAGGDDKIFAWDWKTGKNLSTFDYNS 282 SAG D + WD TG+ T D + Sbjct: 663 KVQFASAGADTLVKVWDANTGETECTLDNHE 693 Score = 53.6 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 33/177 (18%), Positives = 68/177 (38%), Gaps = 30/177 (16%) Query: 112 SDESRLIACADSDKSLLVFDVDKTS-KNVLKLRKRFCFSKRPNAISIAEDDTTVI----- 165 S +L A A DK++ ++DV+K + +L+ + + A +T VI Sbjct: 553 SPNGKLFASASQDKTVKIWDVEKLEVQGILR-----GHKRGVWTVRFAPLNTPVIQGEQG 607 Query: 166 -----------IADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFII 214 DK ++++ + T E +V + +H+ +D + + Sbjct: 608 SVSGRGVVLTGSGDKTIKLWNLSDYT---CIRTFEGHSHNVLKVVWLHISRDDSITKTKV 664 Query: 215 ---TSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICC-GKDYLLLSAGGDDKIFAW 267 ++ D +K+ + L H+ + ++ K +L SAG D K+ W Sbjct: 665 QFASAGADTLVKVWD-ANTGETECTLDNHEDRLWTLAVHSKTNILASAGSDSKVTFW 720 >5NNZ-B nrPDB Length = 415 Score = 62.8 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 36/178 (20%), Positives = 65/178 (36%), Gaps = 18/178 (10%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 I +L + R+I D +++V+D D K + + ++ S D + + Sbjct: 222 IISLSFNTSGDRIIT-GSFDHTVVVWDADTGRKVNILI----GHCAEISSASFNWDCSLI 276 Query: 165 IIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHI 222 + DK ++ + + T + GH + D + I T+ D Sbjct: 277 LTGSMDKTCKLWDA---TNGKCVAT---LTGHDDEILDSCF---DYTGKLIATASADGTA 327 Query: 223 KISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDK-IFAWDWKTGKNLSTFD 279 +I + K L GH+ +S I L G DK WD +TG+ L + Sbjct: 328 RIFSAATRKCIAK-LEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLE 384 Score = 62.1 bits (149), Expect = 5e-10, Method: Composition-based stats. Identities = 37/169 (21%), Positives = 57/169 (33%), Gaps = 19/169 (11%) Query: 118 IACADSDKSLLVFDVDKTSKNVLKLRKRF-CFSKRPNAISIAEDDTTVIIA--DKFGDVY 174 IA DK+ ++ V+ K F + +S T V D ++ Sbjct: 150 IATGSFDKTCKLWSVETG-----KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLW 204 Query: 175 SIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVD 234 I EE +T + GH + + + D IIT D + + Sbjct: 205 DIQN---GEEVYT---LRGHSAEIISLSFNTSGDR---IITGSFDHTVVVWD-ADTGRKV 254 Query: 235 KWLFGHKHFVSSICCGKDYLLLSAGGDDKIF-AWDWKTGKNLSTFDYNS 282 L GH +SS D L+ G DK WD GK ++T + Sbjct: 255 NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHD 303 Score = 61.3 bits (147), Expect = 9e-10, Method: Composition-based stats. Identities = 31/178 (17%), Positives = 56/178 (31%), Gaps = 19/178 (10%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIA---EDD 161 + N+ L S I D++ ++D +L AI+ D Sbjct: 95 LTNVALNKSGSCFIT-GSYDRTCKLWDTASGE----ELNTLEGHRNVVYAIAFNNPYGDK 149 Query: 162 TTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEH 221 DK ++S++ + T GH + + + S + T D Sbjct: 150 IATGSFDKTCKLWSVET---GKCYHT---FRGHTAEIVCLSFNPQS---TLVATGSMDTT 200 Query: 222 IKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG-DDKIFAWDWKTGKNLSTF 278 K+ V L GH + S+ + G D + WD TG+ ++ Sbjct: 201 AKLWDIQNGEEVYT-LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNIL 257 Score = 48.2 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 22/131 (16%), Positives = 45/131 (34%), Gaps = 12/131 (9%) Query: 155 ISIAEDDTTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQF 212 +++ + + I D+ ++ EE T E GH +++ + Sbjct: 98 VALNKSGSCFITGSYDRTCKLWDTAS---GEELNTLE---GHRNVVYAIAFNNPYGDK-- 149 Query: 213 IITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG-DDKIFAWDWKT 271 I T D+ K+ + GH + + L++ G D WD + Sbjct: 150 IATGSFDKTCKLWSVETGKCYHTF-RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN 208 Query: 272 GKNLSTFDYNS 282 G+ + T +S Sbjct: 209 GEEVYTLRGHS 219 >5GAN-H nrPDB Length = 465 Score = 62.8 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 37/165 (22%), Positives = 67/165 (40%), Gaps = 14/165 (8%) Query: 107 NLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVII 166 +L D S L+ D +++D+ S K+ SK ++ + + V Sbjct: 312 SLSFQCDGS-LVCSGGMDSLSMLWDIRSGS----KVMTLAGHSKPIYTVAWSPNGYQVAT 366 Query: 167 A--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI 224 D +V+ DI E + Q IL H +++T V K+ DG + +++ D I + Sbjct: 367 GGGDGIINVW--DIRKRDEGQLNQ--ILAHRNIVTQVRFSKE-DGGKKLVSCGYDNLINV 421 Query: 225 SHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG-DDKIFAWD 268 ++ L GH + S+ + L +GG D I W+ Sbjct: 422 YS-SDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 51.3 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 38/198 (19%), Positives = 74/198 (37%), Gaps = 15/198 (7%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRF-CFSKRPNAISIAED-DT 162 I + L++D ++A L V + S+ + L ++ + AI D + Sbjct: 178 ISAVSLSTD-DMVVATGSWAGDLQVLN----SQTLQPLTQKLDSHVGKIGAIDWHPDSNN 232 Query: 163 TVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHI 222 +I + G + + ++ ++GH ++DV +FI ++ D Sbjct: 233 QMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHP---SGKFIGSASHDMTW 289 Query: 223 KISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG-DDKIFAWDWKTGKNLSTFDYN 281 ++ GH V S+ D L+ +GG D WD ++G + T + Sbjct: 290 RLWD-ASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGH 348 Query: 282 SLIKPYLNDQHLAPPRFQ 299 S KP +P +Q Sbjct: 349 S--KPIYT-VAWSPNGYQ 363 Score = 50.1 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 26/145 (17%), Positives = 56/145 (38%), Gaps = 20/145 (13%) Query: 86 RTAAKVPSPGLGAPPIYSYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKR 145 R+ +KV + + PIY+ S +A D + V+D+ K ++ +L + Sbjct: 337 RSGSKVMTLAGHSKPIYT-----VAWSPNGYQVATGGGDGIINVWDIRK--RDEGQLNQI 389 Query: 146 FCFSKRPNAISIAEDD--TTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDV 201 + +++D ++ D +VYS D + GH + + Sbjct: 390 LAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDT------WLKMGSLAGHTDKIISL 443 Query: 202 HLIKDSDGHQFIITSDRDEHIKISH 226 + +S F+++ D IK+ + Sbjct: 444 DISNNSH---FLVSGGWDRSIKLWN 465 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 38/226 (16%), Positives = 71/226 (31%), Gaps = 40/226 (17%) Query: 115 SRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA--DKFGD 172 +++I+CA+ D + F + L +R + + + A D Sbjct: 232 NQMISCAE-DGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWR 290 Query: 173 VYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFI 232 ++ + +E QE GH + + D + + D + Sbjct: 291 LWDASTH---QELLLQE---GHDKGVFSLSFQCDG---SLVCSGGMDSLSMLWDIRSGSK 341 Query: 233 VDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIF-AWDWKT-------------------- 271 V L GH + ++ + ++ GG D I WD + Sbjct: 342 VMT-LAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVR 400 Query: 272 ------GKNLSTFDYNSLIKPYLNDQHLAPPRFQNENNDIIEFAVS 311 GK L + Y++LI Y +D L + II +S Sbjct: 401 FSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDIS 446 >6QX9-5O nrPDB Length = 357 Score = 62.1 bits (149), Expect = 5e-10, Method: Composition-based stats. Identities = 28/204 (13%), Positives = 77/204 (37%), Gaps = 27/204 (13%) Query: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDT 162 S++ + +L+ D ++ ++D+ K + + F + + A++ + Sbjct: 152 SFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAI-----QTFQNTYQVLAVTFNDTSD 206 Query: 163 TVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDE 220 +I D V+ + N + +T + GH +T + L + +++++ D Sbjct: 207 QIISGGIDNDIKVWDLRQNKL---TYT---MRGHADSVTGLSLSSEG---SYLLSNAMDN 257 Query: 221 HIKISHY------PQC-FIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDK-IFAWDWKTG 272 +++ +C I + + + D ++AG D+ ++ WD + Sbjct: 258 TVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSR 317 Query: 273 KNLSTFDYNSLIKPYLNDQHLAPP 296 + L ++ +N+ P Sbjct: 318 RILYKLPGHA---GSINEVAFHPD 338 Score = 53.6 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 31/170 (18%), Positives = 62/170 (36%), Gaps = 20/170 (11%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 + L +D S L + A +DK++ V+D + ++++ + N+ A + Sbjct: 112 VMELHYNTDGSMLFS-ASTDKTVAVWDSETGE----RVKRLKGHTSFVNSCYPARRGPQL 166 Query: 165 I---IADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEH 221 + D ++ I K + + V +D II+ D Sbjct: 167 VCTGSDDGTVKLWDIR-------KKAAIQTFQNTYQVLAVTF---NDTSDQIISGGIDND 216 Query: 222 IKISHYPQCFIVDKWLFGHKHFVSSICCGKDYL-LLSAGGDDKIFAWDWK 270 IK+ Q + + GH V+ + + LLS D+ + WD + Sbjct: 217 IKVWDLRQNKLTYT-MRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265 Score = 46.6 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 23/103 (22%), Positives = 37/103 (35%), Gaps = 9/103 (8%) Query: 182 PEEKFTQEPIL---GHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISH-YPQCFIVDKWL 237 P Q PI+ GH + + + ++ D I + + Y C L Sbjct: 50 PRCSSLQAPIMLLSGHEGEVYCCKFHPNG---STLASAGFDRLILLWNVYGDCDNYAT-L 105 Query: 238 FGHKHFVSSICCGKDYLLLSAGGDDKIFA-WDWKTGKNLSTFD 279 GH V + D +L + DK A WD +TG+ + Sbjct: 106 KGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLK 148 Score = 31.2 bits (69), Expect = 0.86, Method: Composition-based stats. Identities = 20/81 (24%), Positives = 39/81 (48%), Gaps = 8/81 (9%) Query: 101 IYSYIRNLRLTS---DESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISI 157 ++++ +NL S D S+ IA +D+ + V+D TS+ +L K + N ++ Sbjct: 281 VHNFEKNLLRCSWSPDGSK-IAAGSADRFVYVWD--TTSRRIL--YKLPGHAGSINEVAF 335 Query: 158 AEDDTTVIIADKFGDVYSIDI 178 D+ +I A +Y +I Sbjct: 336 HPDEPIIISASSDKRLYMGEI 356 >6ID0-T nrPDB Length = 514 Score = 61.3 bits (147), Expect = 9e-10, Method: Composition-based stats. Identities = 35/225 (15%), Positives = 75/225 (33%), Gaps = 27/225 (12%) Query: 84 IKRTAAKVPSPGLGAP-PIYSYIRN------LRLTSDESRLIACADSDKSLLVFDVDKTS 136 + + A +P P P +Y I ++ +D+++ ++D+ Sbjct: 178 MAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGK 237 Query: 137 KNVLKLRKRFCFSKRPNAISIAEDDTTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGH 194 + + ++ + DK + ++ N + GH Sbjct: 238 LKLSLT----GHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYH------GH 287 Query: 195 VSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICC-GKDY 253 +S + + L D ++T RD +I + L GH + V+++ C + Sbjct: 288 LSAVYGLDLHPTID---VLVTCSRDSTARIWDV-RTKASVHTLSGHTNAVATVRCQAAEP 343 Query: 254 LLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAPPRF 298 +++ D I WD GK T + K + L P + Sbjct: 344 QIITGSHDTTIRLWDLVAGKTRVTLTNH---KKSVRAVVLHPRHY 385 Score = 60.9 bits (146), Expect = 9e-10, Method: Composition-based stats. Identities = 28/161 (17%), Positives = 59/161 (36%), Gaps = 17/161 (10%) Query: 117 LIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA--DKFGDVY 174 ++ D + ++DV +T +V L + + + +I D ++ Sbjct: 302 VLVTCSRDSTARIWDV-RTKASVHTLS---GHTNAVATVRCQAAEPQIITGSHDTTIRLW 357 Query: 175 SIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVD 234 + T+ + H + V L + S ++IK +P + Sbjct: 358 DLVAGK------TRVTLTNHKKSVRAVVL----HPRHYTFASGSPDNIKQWKFPDGSFIQ 407 Query: 235 KWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNL 275 L GH ++++ D +L+S + + WDW+TG N Sbjct: 408 N-LSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNF 447 Score = 58.2 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 30/185 (16%), Positives = 63/185 (34%), Gaps = 18/185 (9%) Query: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISI--AED 160 S +R + +++ L +C + DK + +D++ +R + + D Sbjct: 247 STVRGVIVSTRSPYLFSCGE-DKQVKCWDLEYNKV----IRHYHGHLSAVYGLDLHPTID 301 Query: 161 DTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDE 220 D ++ + K + + GH + + V IIT D Sbjct: 302 VLVTCSRDSTARIWDVRT------KASVHTLSGHTNAVATVRCQA---AEPQIITGSHDT 352 Query: 221 HIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFD- 279 I++ L HK V ++ + ++G D I W + G + Sbjct: 353 TIRLWDLVAGKTRVT-LTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSG 411 Query: 280 YNSLI 284 +N++I Sbjct: 412 HNAII 416 >5K1B-B nrPDB Length = 677 Score = 59.7 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 32/186 (17%), Positives = 73/186 (39%), Gaps = 17/186 (9%) Query: 104 YIRNLRLTSDESRLIACADSDKSLLVFDVDKT-SKNVLKLRKRFCFSKRPNAISIAEDDT 162 ++ ++ L + LI+ A SD ++ V++ K + L+ K + A++ A+D Sbjct: 77 WVNDIVLCCNGKTLIS-ASSDTTVKVWNAHKGFCMSTLRTHKDY-----VKALAYAKDKE 130 Query: 163 TVIIADKFGDVYSIDINSI-----PEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSD 217 V A ++ D+N++ T + G+ + L + G I++ Sbjct: 131 LVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKD--SIYSLAMNQLGT-IIVSGS 187 Query: 218 RDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIF-AWDWKTGKNLS 276 ++ +++ C L GH V ++ +D +G D W + ++ Sbjct: 188 TEKVLRVWDPRTCA-KLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIA 246 Query: 277 TFDYNS 282 T+ + Sbjct: 247 TYRVHD 252 Score = 57.8 bits (138), Expect = 8e-09, Method: Composition-based stats. Identities = 24/105 (22%), Positives = 50/105 (47%), Gaps = 8/105 (7%) Query: 168 DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHY 227 D ++S+ N ++ + + H + D+ L + + +I++ D +K+ + Sbjct: 51 DSIIRIWSV--NQHKQDPYIAS-MEHHTDWVNDIVLCCNG---KTLISASSDTTVKVWNA 104 Query: 228 PQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG-DDKIFAWDWKT 271 + F + L HK +V ++ KD L+++ G D +IF WD T Sbjct: 105 HKGFCMST-LRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT 148 >5FVM-C nrPDB Length = 303 Score = 59.7 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 28/180 (15%), Positives = 70/180 (38%), Gaps = 17/180 (9%) Query: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDT 162 S + L +TSD+ L A + ++D+ + N + + +I+ +++ Sbjct: 33 SQVNRLEITSDKKYLAAAGHLH--VRLYDIRSNNPNPVSSFE--GHKGNVTSIAFQQENR 88 Query: 163 TVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDE 220 ++ + D V+ + S+ + H + + +V + + +I+ D+D Sbjct: 89 WMVSSSEDGTIKVWDVRSPSV-------QRNYKHNAPVNEVAIHPN---QGELISCDQDG 138 Query: 221 HIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDK-IFAWDWKTGKNLSTFD 279 +I+I + ++ + S+ D +L AG + + W + ST + Sbjct: 139 NIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLE 198 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 35/194 (18%), Positives = 78/194 (40%), Gaps = 18/194 (9%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 + + + ++ LI+C D D ++ ++D+ + + + ++S+A D + + Sbjct: 119 VNEVAIHPNQGELISC-DQDGNIRIWDLGENQCTNQLTPED---NTPLQSLSVASDGSML 174 Query: 165 IIADKFGD--VYSIDINSIPEEKFTQEPI---LGHVSMLTDVHLIKDSDGHQFIITSDRD 219 + + G+ V+ + ++ T EP+ H +T V L D + T D Sbjct: 175 VAGNNKGNCYVWRMPHHTDAS---TLEPVTKFKSHTKYITRVLLSADVKN---LATCSAD 228 Query: 220 EHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYL-LLSAGGDDKIFAWDWKTGK--NLS 276 ++ + + ++ L GH+ +V D L++A D + WD T + Sbjct: 229 HTARVWNIEDNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQY 288 Query: 277 TFDYNSLIKPYLND 290 + + LND Sbjct: 289 GGHHKGAVCVALND 302 >5WYJ-BC nrPDB Length = 817 Score = 59.7 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 42/175 (24%), Positives = 78/175 (44%), Gaps = 20/175 (11%) Query: 118 IACADSDKSLLVFDVDKTSKN----VLKLRK--RFCFSKRPNAISIAEDDTTVIIA--DK 169 + A +D ++ + + K + + ++K+ + R K NA+S++ +D+ A DK Sbjct: 454 LLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDK 513 Query: 170 FGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQ 229 +++++ + + + H L DV + + + TS D+ +KI Sbjct: 514 TCKIWNLENGEL------EATLANHKRGLWDVSFCQ---YDKLLATSSGDKTVKIWSL-D 563 Query: 230 CFIVDKWLFGHKHFVSSIC-CGKDYLLLSAGGDDKIFAWDWKTGKNLSTFD-YNS 282 F V K L GH + V K L+S G D I WD +G+ L T D +N+ Sbjct: 564 TFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTLDGHNN 618 Score = 57.4 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 29/162 (17%), Positives = 62/162 (38%), Gaps = 17/162 (10%) Query: 112 SDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVI--IADK 169 S + A A DK+ +++++ + +S + D + DK Sbjct: 500 SPNDSIFATASYDKTCKIWNLENGELEATLAN----HKRGLWDVSFCQYDKLLATSSGDK 555 Query: 170 FGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQ 229 ++S+D S+ + + GH + + I + + +I+ D IKI Sbjct: 556 TVKIWSLDTFSV------MKTLEGHTNAVQRCSFI---NKQKQLISCGADGLIKIWDCSS 606 Query: 230 CFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKT 271 + K L GH + + ++ D ++ + D +F + WK Sbjct: 607 GECL-KTLDGHNNRLWALSTMNDGDMIVSADADGVFQF-WKD 646 Score = 57.0 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 37/214 (17%), Positives = 70/214 (32%), Gaps = 31/214 (14%) Query: 91 VPSPGLGAPP--------IYSYIRNLRLTSDESR---LIACADSDKSLLVFDVDKTSKNV 139 +P P L P IY +L + D + IA A D + +V+ ++ S Sbjct: 365 IPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKF 424 Query: 140 LKLRKRFCFSKRPNAISIAE-------DDTTVIIADKFGDVY-------SIDINSIPEEK 185 K S A+ + + D + S+D+ I + Sbjct: 425 DIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSE 484 Query: 186 FTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVS 245 +T+ ++ L+ + +D T+ D+ KI + + + Sbjct: 485 YTRHAHEKDINALS----VSPNDS--IFATASYDKTCKIWNLENGELEATLANHKRGLWD 538 Query: 246 SICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFD 279 C D LL ++ GD + W T + T + Sbjct: 539 VSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLE 572 >4YCZ-A nrPDB Length = 876 Score = 59.4 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 31/178 (17%), Positives = 60/178 (33%), Gaps = 36/178 (20%) Query: 117 LIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIA-----------------E 159 L+ACA SD ++ V + N + N++S A Sbjct: 124 LLACASSDGNVSVLEF---RDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKST 180 Query: 160 DDTTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSD 217 + + D +++ D + K +EP+ GH + DV +I ++ Sbjct: 181 GNRRFVTGGSDNALKIWAYDPAT-NTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASAS 239 Query: 218 RDEHIKISHYP-------QCFIVDKWLFGHKHFVSSICCGKDYL-LLSAGGDDKIFAW 267 D ++I C +++ V + L ++GGD+K+ W Sbjct: 240 EDRTVRIWTSDPANPLQWNCKVLN-----FDAAVWRVSWSLSGNVLAASGGDNKVTLW 292 >5UZ7-B nrPDB Length = 351 Score = 59.0 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 29/184 (15%), Positives = 67/184 (36%), Gaps = 13/184 (7%) Query: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDT 162 S++ + +AC D ++++ NV R+ + + +D+ Sbjct: 109 SWVMTCAYAPSGNY-VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ 167 Query: 163 TVII-ADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEH 221 V D ++ I E GH + + L D+ + ++ D Sbjct: 168 IVTSSGDTTCALWDI------ETGQQTTTFTGHTGDVMSLSLAPDT---RLFVSGACDAS 218 Query: 222 IKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIF-AWDWKTGKNLSTFDY 280 K+ + + GH+ +++IC + + G DD +D + + L T+ + Sbjct: 219 AKLWDVREGMCRQTF-TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSH 277 Query: 281 NSLI 284 +++I Sbjct: 278 DNII 281 Score = 46.6 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 26/156 (16%), Positives = 55/156 (35%), Gaps = 11/156 (7%) Query: 119 ACADSDKSLLVFDVDKTSKNVLKLRKRF-CFSKRPNAISIAEDDTTVIIADKFGDVYSID 177 ACAD+ S + ++D + ++ R+ + A+ D ++ A + G + D Sbjct: 35 ACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD 94 Query: 178 INSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCF---IVD 234 + + I S + + ++ D I + V Sbjct: 95 SYTTNKV----HAIPLRSSWVMTCAYAPSGN---YVACGGLDNICSIYNLKTREGNVRVS 147 Query: 235 KWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWK 270 + L GH ++S D ++++ GD WD + Sbjct: 148 RELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIE 183 Score = 36.2 bits (82), Expect = 0.028, Method: Composition-based stats. Identities = 29/168 (17%), Positives = 59/168 (35%), Gaps = 18/168 (10%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRF-CFSKRPNAISIAEDDTT 163 + +L L D +RL D S ++DV + R+ F NAI + Sbjct: 198 VMSLSLAPD-TRLFVSGACDASAKLWDVREGM-----CRQTFTGHESDINAICFFPNGNA 251 Query: 164 VIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEH 221 D ++ + + +E T H +++ + + S + ++ D + Sbjct: 252 FATGSDDATCRLFDLRAD---QELMT----YSHDNIICGITSVSFSKSGRLLLAGYDDFN 304 Query: 222 IKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIF-AWD 268 + + L GH + VS + D + ++ G D W+ Sbjct: 305 CNVWDALKAD-RAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 351 >1NR0-A nrPDB Length = 611 Score = 59.0 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 49/217 (22%), Positives = 79/217 (36%), Gaps = 27/217 (12%) Query: 81 GDSIK----RTAAKVPSPGLGAPPIY---SYIRNLRLTSDESRLIACADSDKSLLVFDVD 133 GD I+ + VP L IY S+ + TS A D ++ ++D Sbjct: 30 GDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTT 89 Query: 134 KTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA----DKFGDVYSIDINSIPEEKFTQE 189 +T+ ++LK FS IS + + ++FG V+ D + + Sbjct: 90 QTT-HILKTTIPV-FSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGT------SNG 141 Query: 190 PILGHVSMLTDVHLIKDSDGHQF-IITSDRDEHIKISHYPQCFIVDKWLFG-HKHFVSSI 247 + G + V F II+ D + I P FG H FV S+ Sbjct: 142 NLTGQARAMNSVDFKP---SRPFRIISGSDDNTVAIFEGPPFKFKST--FGEHTKFVHSV 196 Query: 248 CCGKDYLLLSA-GGDDKIFAWDWKTGKNLSTFDYNSL 283 D L ++ GGD I ++ G F+ +SL Sbjct: 197 RYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSL 233 Score = 39.3 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 26/117 (22%), Positives = 47/117 (40%), Gaps = 12/117 (10%) Query: 145 RFCFSKRPNAISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLI 204 R+ +K A+S + D T+ AD G + S DI++ + + H +M+T + Sbjct: 320 RYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDV---HATMITGIKTT 376 Query: 205 KDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGD 261 D + T D+H+K+ + K + + L +SA GD Sbjct: 377 SKGD----LFTVSWDDHLKVVPAGGSGVDSS-----KAVANKLSSQPLGLAVSADGD 424 Score = 37.0 bits (84), Expect = 0.018, Method: Composition-based stats. Identities = 22/170 (12%), Positives = 51/170 (30%), Gaps = 46/170 (27%) Query: 100 PIYSYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAE 159 PI SY + S++ + +A D + V+ + S + +K +++ + Sbjct: 446 PI-SYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKT---IVHPAEITSVAFSN 501 Query: 160 DDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDS------------ 207 + ++ D+ V + + E T H + + V D+ Sbjct: 502 NGAFLVATDQSRKVIPYSVANNFELAHTNSWTF-HTAKVACVSWSPDNVRLATGSLDNSV 560 Query: 208 -----------------------------DGHQFIITSDRDEHIKISHYP 228 I+++ +D +IK + P Sbjct: 561 IVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNVP 610 Score = 35.9 bits (81), Expect = 0.033, Method: Composition-based stats. Identities = 29/202 (14%), Positives = 60/202 (29%), Gaps = 55/202 (27%) Query: 118 IACADSDKSLLVFDVDKTSKNVLKLRKRFC-FSKRPNAISIAEDDTTVII--ADKFGDVY 174 I D ++ +F+ K + F +K +++ D + D +Y Sbjct: 163 IISGSDDNTVAIFE-----GPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLY 217 Query: 175 S-IDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFI- 232 + +D + + H + + D I ++ D+ IKI + + Sbjct: 218 NGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTK---IASASADKTIKIWNVATLKVE 274 Query: 233 -----------------------------------------VDKWLFGHKHFVSSICCGK 251 +D+ +GH ++++ Sbjct: 275 KTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSA 334 Query: 252 DY-LLLSAGGDDKIFAWDWKTG 272 D L SA + I +WD TG Sbjct: 335 DGKTLFSADAEGHINSWDISTG 356 Score = 33.6 bits (75), Expect = 0.20, Method: Composition-based stats. Identities = 28/189 (14%), Positives = 59/189 (31%), Gaps = 31/189 (16%) Query: 100 PIYSY-IRNLRLTSDESRLIACADSDKSL-LVFDVDKTSKNVLKLRKRFCFSKRPNAISI 157 P++S ++++ S+ R+ A + + VF D + N ++ N++ Sbjct: 100 PVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLT----GQARAMNSVDF 155 Query: 158 AEDDT-TVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFII 214 +I D ++ P KF H + V D Sbjct: 156 KPSRPFRIISGSDDNTVAIFEG-----PPFKFKSTFGE-HTKFVHSVRYNPDG---SLFA 206 Query: 215 TSDRDEHIKISH---------YPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIF 265 ++ D I + + + + + H V + D +++ DK Sbjct: 207 STGGDGTIVLYNGVDGTKTGVFEDDSLKN---VAHSGSVFGLTWSPDGTKIASASADKTI 263 Query: 266 -AWDWKTGK 273 W+ T K Sbjct: 264 KIWNVATLK 272 >5NZU-C nrPDB Length = 905 Score = 58.6 bits (140), Expect = 5e-09, Method: Composition-based stats. Identities = 29/185 (15%), Positives = 62/185 (33%), Gaps = 18/185 (9%) Query: 104 YIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISI--AEDD 161 Y+ + + ++ A A D+++ V+ + +S N K N I D Sbjct: 144 YVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLE----GHEKGVNCIDYYSGGDK 199 Query: 162 TTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRD 219 +I D+ ++ + K + + GH ++ + IIT D Sbjct: 200 PYLISGADDRLVKIWDY------QNKTCVQTLEGHAQNVSCASFHPEL---PIIITGSED 250 Query: 220 EHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFD 279 ++I H + +G + V + + ++ G D+ + + D Sbjct: 251 GTVRIWHSSTYRLESTLNYGMER-VWCVASLRGSNNVALGYDEGSIIVKLGREEPAMSMD 309 Query: 280 YNSLI 284 N I Sbjct: 310 ANGKI 314 Score = 49.0 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 22/130 (16%), Positives = 40/130 (30%), Gaps = 9/130 (6%) Query: 152 PNAISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQ 211 A V+ + + N++ H + + + Sbjct: 60 VRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHM----FEAHSDYIRCIAVHP---TQP 112 Query: 212 FIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGK--DYLLLSAGGDDKIFAWDW 269 FI+TS D IK+ + + + + GH H+V I + SA D I W Sbjct: 113 FILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQL 172 Query: 270 KTGKNLSTFD 279 + T + Sbjct: 173 GSSSPNFTLE 182 >4J0W-A nrPDB Length = 343 Score = 58.6 bits (140), Expect = 6e-09, Method: Composition-based stats. Identities = 37/199 (18%), Positives = 79/199 (39%), Gaps = 19/199 (9%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFC-------FSKRPNAISI 157 I L +T D+S I A D S++ + V+ K + R + S ++I Sbjct: 17 ITCLVVTPDDS-AIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAI 75 Query: 158 AEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSD 217 + D + D+ + I + +T GH ++ + + + + ++ Sbjct: 76 SSDGKYLASGDRS-KLILIWEAQSCQHLYT---FTGHRDAVSGLAFRRGTHQ---LYSTS 128 Query: 218 RDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDK-IFAWDWKTGKNLS 276 D +K+ + + V+ LFGH+ V+++ ++AGG D + W L Sbjct: 129 HDRSVKVWNVAENSYVET-LFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLV 187 Query: 277 TFDYNSLIK--PYLNDQHL 293 + + I +N++H+ Sbjct: 188 FYGHQGSIDCIHLINEEHM 206 Score = 57.0 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 30/183 (16%), Positives = 72/183 (39%), Gaps = 21/183 (11%) Query: 97 GAPPIYS-YIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAI 155 G PP +S ++ + ++SD +A D K +L+++ ++ +++ + + Sbjct: 61 GKPPGHSSHVLCMAISSDGKY-LASGDRSKLILIWE-AQSCQHLYTFT---GHRDAVSGL 115 Query: 156 SIAEDDTTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFI 213 + + D+ V+++ NS E F GH + + D+ + Sbjct: 116 AFRRGTHQLYSTSHDRSVKVWNVAENSYVETLF------GHQDAVAAL----DALSRECC 165 Query: 214 ITSD-RDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKTG 272 +T+ RD +++ P+ +GH+ + I + ++S D + W Sbjct: 166 VTAGGRDGTVRVWKIPE--ESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKK 223 Query: 273 KNL 275 + L Sbjct: 224 RPL 226 >3C9C-A nrPDB Length = 432 Score = 57.8 bits (138), Expect = 8e-09, Method: Composition-based stats. Identities = 27/176 (15%), Positives = 66/176 (37%), Gaps = 15/176 (8%) Query: 116 RLIACADSDKSLLVFDVDKTSKN--VLKLRKRF-CFSKRPNAISIAEDDTTV---IIADK 169 L++ +D D ++ ++D++ T K V+ + F + ++ ++ + D+ Sbjct: 198 YLLSASD-DHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQ 256 Query: 170 FGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQ 229 ++ N+ + T + H + + + + T D+ + + Sbjct: 257 KLMIWDTRNNNTSKPSHT---VDAHTAEVNCLSFNP--YSEFILATGSADKTVALWDLRN 311 Query: 230 CFIVDKWLFGHKHFVSSICCGK--DYLLLSAGGDDKIFAWDW-KTGKNLSTFDYNS 282 + HK + + + +L S+G D ++ WD K G+ ST D Sbjct: 312 LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED 367 >3ODT-A nrPDB Length = 313 Score = 57.4 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 39/192 (20%), Positives = 72/192 (37%), Gaps = 20/192 (10%) Query: 97 GAPPIYSYIR---NLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPN 153 G P+Y+ I N+ S + ++ DK+ V+ K V L+ Sbjct: 93 GEDPLYTLIGHQGNVCSLSFQDGVVISGSWDKTAKVW---KEGSLVYNLQAHNASVWDAK 149 Query: 154 AISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFI 213 +S +E+ ADK ++ D I ++ H++++ D H Sbjct: 150 VVSFSENKFLTASADKTIKLWQND-KVIKTFSGIHNDVVRHLAVVDDGHF---------- 198 Query: 214 ITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKTG- 272 I+ D IK+ ++ + GH+ FV I + ++S G D + W + G Sbjct: 199 ISCSNDGLIKLVDMHTGDVLRTY-EGHESFVYCIKLLPNGDIVSCGEDRTVRIWSKENGS 257 Query: 273 -KNLSTFDYNSL 283 K + T S+ Sbjct: 258 LKQVITLPAISI 269 Score = 33.6 bits (75), Expect = 0.16, Method: Composition-based stats. Identities = 29/160 (18%), Positives = 55/160 (34%), Gaps = 24/160 (15%) Query: 165 IIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLI----KDSDGH--QFIITSDR 218 + D ++S D + +T + L V ++ L+ KD+ + TS Sbjct: 35 VSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDTMINGVPLFATSGE 94 Query: 219 DEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTF 278 D L GH+ V S+ +D +++S D W K G + Sbjct: 95 DPLY-------------TLIGHQGNVCSLSF-QDGVVISGSWDKTAKVW--KEGSLVYNL 138 Query: 279 DYNSLIKPYLNDQHLAPPRFQNENND--IIEFAVSKIIKS 316 ++ + +F + D I + K+IK+ Sbjct: 139 QAHNASVWDAKVVSFSENKFLTASADKTIKLWQNDKVIKT 178 Score = 30.5 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 11/53 (20%), Positives = 24/53 (45%), Gaps = 1/53 (1%) Query: 213 IITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIF 265 + + RD +++ ++ G + F++S+C + LL GG D + Sbjct: 32 VASVSRDGTVRLWSKDDQWLGTVVYTG-QGFLNSVCYDSEKELLLFGGKDTMI 83 >5WYK-BB nrPDB Length = 943 Score = 57.0 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 32/164 (19%), Positives = 68/164 (41%), Gaps = 18/164 (10%) Query: 108 LRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVI-- 165 +R++ D+ +A + D ++ VF +D + K L L + +I I+ D +I Sbjct: 537 VRVSPDDRY-LAISLLDNTVKVFFLD-SMKFYLSL---YGHKLPVLSIDISFDSKMIITS 591 Query: 166 IADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKIS 225 ADK ++ +D + + + H + +V + S + +D +K Sbjct: 592 SADKNIKIWGLD---FGDC---HKSLFAHQDSIMNVKFLPQSHN---FFSCSKDAVVKYW 642 Query: 226 HYPQCFIVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWD 268 + + K L+ H+ V ++ D ++S+ D I W+ Sbjct: 643 DGEKFECIQK-LYAHQSEVWALAVATDGGFVVSSSHDHSIRIWE 685 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 41/181 (22%), Positives = 72/181 (39%), Gaps = 30/181 (16%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFC------------FSKRP 152 I +L LTSD RL+ +DK++ +D + V + +F + Sbjct: 476 IWSLDLTSDGKRLVT-GSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDI 534 Query: 153 NAISIAEDDTTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGH 210 + ++ DD + I+ D V+ +D KF + GH + + + DS Sbjct: 535 LCVRVSPDDRYLAISLLDNTVKVFFLD-----SMKFYLS-LYGHKLPVLSIDISFDS--- 585 Query: 211 QFIITSDRDEHIKIS--HYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIF-AW 267 + IITS D++IKI + C K LF H+ + ++ + D + W Sbjct: 586 KMIITSSADKNIKIWGLDFGDC---HKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYW 642 Query: 268 D 268 D Sbjct: 643 D 643 Score = 30.9 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 22/111 (19%), Positives = 41/111 (36%), Gaps = 10/111 (9%) Query: 167 ADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISH 226 AD V+ + ++ GH + +T + +I+ +D +I + Sbjct: 99 ADGVIKVWDLMSKTV------LLNFNGHKAAITLLQFDGTGTR---LISGSKDSNIIVWD 149 Query: 227 YPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLST 277 + L HK ++ C + L+S D I WD KT + + T Sbjct: 150 LVG-EVGLYKLRSHKDSITGFWCQGEDWLISTSKDGMIKLWDLKTHQCIET 199 >4A11-B nrPDB Length = 408 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 42/208 (20%), Positives = 75/208 (36%), Gaps = 31/208 (14%) Query: 87 TAAKVPSPGLGAPPIYSY-IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKR 145 T V S G P ++ Y + ++ ++ + + DK+L V+D N L+ Sbjct: 83 TCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWD-----TNTLQTADV 137 Query: 146 FCFSKRPNAISIAEDDTT---VIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVH 202 F F + + ++ T V + + V D+ S + GH + V Sbjct: 138 FNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKS-GSCSHI---LQGHRQEILAVS 193 Query: 203 LIKDSDGHQFIITSDRDEHIKISHY---PQCFIVDKWLFG------------HKHFVSSI 247 D + T+ D +K+ C I G H V+ + Sbjct: 194 WSPRYDY--ILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGL 251 Query: 248 CCGKDYL-LLSAGGDDKIFAWDWKTGKN 274 C D L LL+ G D+++ W+ G+N Sbjct: 252 CFTSDGLHLLTVGTDNRMRLWNSSNGEN 279 >6EMK-B nrPDB Length = 303 Score = 55.9 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 28/170 (16%), Positives = 67/170 (39%), Gaps = 17/170 (10%) Query: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDT 162 S + L +T+D+ L +++ ++D+ T+ N + + ++S +D+ Sbjct: 33 SQVNRLEITNDKKLLATAGH--QNVRLYDIRTTNPNPVASFE--GHRGNVTSVSFQQDNR 88 Query: 163 TVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDE 220 ++ + D V+ + SIP H + + +V + + +I+ DRD Sbjct: 89 WMVTSSEDGTIKVWDVRSPSIPR-------NYKHNAPVNEVVIHPN---QGELISCDRDG 138 Query: 221 HIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDK-IFAWDW 269 +I+I + + + S+ D +L+A + W+ Sbjct: 139 NIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEM 188 Score = 52.8 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 30/170 (17%), Positives = 68/170 (40%), Gaps = 10/170 (5%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 + + + ++ LI+C D D ++ ++D+ + + ++S+A D + + Sbjct: 119 VNEVVIHPNQGELISC-DRDGNIRIWDLGENQCTHQLTPED---DTSLQSLSMASDGSML 174 Query: 165 IIADKFGD--VYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHI 222 A+ G+ V+ + ++ H + +T + L D + + T D Sbjct: 175 AAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDV---KHLATCSADHTA 231 Query: 223 KISHYPQCFIVDKWLFGHKHFVSSICCGKDYL-LLSAGGDDKIFAWDWKT 271 ++ F ++ L GH+ +V D L++A D + WD T Sbjct: 232 RVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLST 281 Score = 50.9 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 33/144 (22%), Positives = 65/144 (45%), Gaps = 13/144 (9%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDV-DKTSKNVLKLRKRF-CFSKRPNAISIAEDDT 162 +++L + SD S ++A A++ + V+++ + T + LK +F S I ++ D Sbjct: 162 LQSLSMASDGS-MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVK 220 Query: 163 TVI--IADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDE 220 + AD V+SID + E + GH + D DS +++T+ D Sbjct: 221 HLATCSADHTARVWSIDDDFKLETT-----LDGHQRWVWDCAFSADS---AYLVTASSDH 272 Query: 221 HIKISHYPQCFIVDKWLFGHKHFV 244 ++++ IV ++ HK V Sbjct: 273 YVRLWDLSTREIVRQYGGHHKGAV 296 >6Q8F-A nrPDB Length = 514 Score = 55.5 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 22/129 (17%), Positives = 52/129 (40%), Gaps = 18/129 (13%) Query: 112 SDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRF--CFSKRPNAISIAEDDTTVIIA-- 167 S ++ ++A D + V+ + + +RF SK +S ++D + ++ A Sbjct: 274 SRDTEMLATGAQDGKIKVWKIQSG-----QCLRRFERAHSKGVTCLSFSKDSSQILSASF 328 Query: 168 DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHY 227 D+ ++ + T + GH S + + +D +II++ D +KI + Sbjct: 329 DQTIRIHGLKSGK------TLKEFRGHSSFVNEATFTQDGH---YIISASSDGTVKIWNM 379 Query: 228 PQCFIVDKW 236 + + Sbjct: 380 KTTECSNTF 388 Score = 44.0 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 28/143 (19%), Positives = 55/143 (38%), Gaps = 8/143 (5%) Query: 145 RFCFSKRPNAISIAEDDTTVIIA--DKFGDVYSIDINSI-PEEKF-TQEPILGHVSMLTD 200 +F + D ++ D F +V++ I + K+ Q+ + + Sbjct: 211 KFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLC 270 Query: 201 VHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYL-LLSAG 259 + +D+ + + T +D IK+ + ++ H V+ + KD +LSA Sbjct: 271 MCFSRDT---EMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSAS 327 Query: 260 GDDKIFAWDWKTGKNLSTFDYNS 282 D I K+GK L F +S Sbjct: 328 FDQTIRIHGLKSGKTLKEFRGHS 350 >4V7E-Bg nrPDB Length = 380 Score = 54.7 bits (130), Expect = 7e-08, Method: Composition-based stats. Identities = 32/188 (17%), Positives = 64/188 (34%), Gaps = 14/188 (7%) Query: 118 IACADSDKSLLVFDVDKTSK---NVLKLRKRFCFSKRPNAISIAEDDTTVII---ADKFG 171 +AC D + +F++ + N+ R ++ D T +I D+ Sbjct: 123 VACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTC 182 Query: 172 DVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCF 231 ++ + F E GH + + + L +S I+ D +++ Sbjct: 183 VLWDVTTGQRISI-FGSEFPSGHTADV--LSLSINSLNANMFISGSCDTTVRLWDLRITS 239 Query: 232 IVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIF-AWDWKTGKNLSTF----DYNSLIKP 286 + GH+ ++S+ D G DD +D +TG L + D N P Sbjct: 240 RAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELP 299 Query: 287 YLNDQHLA 294 + + Sbjct: 300 IVTSVAFS 307 Score = 42.4 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 29/176 (16%), Positives = 64/176 (36%), Gaps = 19/176 (10%) Query: 104 YIRNLRLTSDESRLIACADSDKSLLVFDVDKTSK-NVLKLRKRFCFSKRPNAISIAEDDT 162 Y + + D+ + D++ +++DV + ++ + ++SI + Sbjct: 159 YASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNA 218 Query: 163 TVIIA---DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRD 219 + I+ D ++ + I S + GH + V D G +F SD D Sbjct: 219 NMFISGSCDTTVRLWDLRITSRAVRTY-----HGHEGDINSVKFFPD--GQRFGTGSD-D 270 Query: 220 EHIKISHYP---QCFIVDKWLFGHKH---FVSSICCGKDYLLLSAGGDDK-IFAWD 268 ++ Q + ++ + + V+S+ LL AG + + WD Sbjct: 271 GTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWD 326 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 24/187 (12%), Positives = 59/187 (31%), Gaps = 31/187 (16%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 + +L + S + + D ++ ++D+ TS+ V R N++ D Sbjct: 208 VLSLSINSLNANMFISGSCDTTVRLWDLRITSRAV---RTYHGHEGDINSVKFFPDGQRF 264 Query: 165 IIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI 224 G D+ + GH + + ++ + + + ++ Sbjct: 265 GTGSDDGTCRLFDMRT------------GHQLQVYNREPDRNDNELPIVTSVAFSISGRL 312 Query: 225 --SHYPQ--CFIVDKWLF-----------GHKHFVSSICCGKDYL-LLSAGGDDKIFAWD 268 + Y C++ D L H+ +S + D L + D + W Sbjct: 313 LFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIWA 372 Query: 269 WKTGKNL 275 + + + Sbjct: 373 FSGHRKI 379 >5MZH-A nrPDB Length = 452 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 27/169 (15%), Positives = 50/169 (29%), Gaps = 17/169 (10%) Query: 114 ESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA--DKFG 171 LI D ++DV + ++ T V+ D Sbjct: 232 GGDLIVTGSFDHDSRLWDVRTGQCVHVLS----GHRGEVSSTQFNYAGTLVVSGSIDCTS 287 Query: 172 DVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCF 231 ++ + K GH + DV ++++ D ++ H Sbjct: 288 RLWDVRSGRCLSVK------QGHTDEVLDVAFDA---AGTKMVSASADGSARLYHTLTGV 338 Query: 232 IVDKWLFGHKHFVSSICCGKDYL-LLSAGGDDKIFAWDWKTGKNLSTFD 279 L GH+ +S + L++A D WD TG+ L + Sbjct: 339 CQHT-LVGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQVLE 386 Score = 53.6 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 32/162 (19%), Positives = 59/162 (36%), Gaps = 17/162 (10%) Query: 118 IACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA--DKFGDVYS 175 I DK+ ++D T + L+ +S T + D ++ Sbjct: 152 IVTGSFDKTCKLWD-AYTGQLYYTLK---GHQTEIVCLSFNPQSTIIATGSMDNTAKLWD 207 Query: 176 IDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDK 235 ++ +E+ T + GH + + + + G I+T D ++ V Sbjct: 208 VET---GQERAT---LAGHRAEIVSLGF---NTGGDLIVTGSFDHDSRLWDVRTGQCVH- 257 Query: 236 WLFGHKHFVSSICCGKDYLLLSAGG-DDKIFAWDWKTGKNLS 276 L GH+ VSS L+ +G D WD ++G+ LS Sbjct: 258 VLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLS 299 Score = 47.0 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 24/126 (19%), Positives = 47/126 (37%), Gaps = 12/126 (9%) Query: 156 SIAEDDTTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFI 213 + + I D+ V++ EE FT E GH +++ + I Sbjct: 101 AFNKSGDRFITGSYDRTCKVWNTFT---GEEVFTLE---GHKNVVYAIAFNNPYGDK--I 152 Query: 214 ITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG-DDKIFAWDWKTG 272 +T D+ K+ + L GH+ + + +++ G D+ WD +TG Sbjct: 153 VTGSFDKTCKLWDAYTGQLYYT-LKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETG 211 Query: 273 KNLSTF 278 + +T Sbjct: 212 QERATL 217 Score = 38.9 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 19/123 (15%), Positives = 44/123 (35%), Gaps = 16/123 (13%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 + ++ + +++++ A +D S ++ + + ++ T + Sbjct: 308 VLDVAFDAAGTKMVS-ASADGSARLYHTLTGVCQHTLV----GHEGEISKVAFNPQGTRL 362 Query: 165 IIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHI 222 I A DK ++ D E + + GH + + D FIIT +D Sbjct: 363 ITASSDKTCRLWDCDT---GEC---LQVLEGHTDEIFSCAFNYEGD---FIITGSKDNTC 413 Query: 223 KIS 225 +I Sbjct: 414 RIW 416 >3CFV-B nrPDB Length = 414 Score = 53.6 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 25/181 (13%), Positives = 63/181 (34%), Gaps = 14/181 (7%) Query: 111 TSDESRLIACADSDKSLLVFDVDKTSKN--VLKLRKRF-CFSKRPNAISIAEDDTTV--- 164 S+ S + A D ++ ++D++ K ++ + F S ++ ++ Sbjct: 188 NSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGS 247 Query: 165 IIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI 224 + D+ ++ N+ + + H + + + + T D+ + + Sbjct: 248 VADDQKLMIWDTRSNTTSK---PSHLVDAHTAEVNCLSFNP--YSEFILATGSADKTVAL 302 Query: 225 SHYPQCFIVDKWLFGHKHFVSSICCGK--DYLLLSAGGDDKIFAWDW-KTGKNLSTFDYN 281 + HK + + + +L S+G D ++ WD K G+ S D Sbjct: 303 WDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAE 362 Query: 282 S 282 Sbjct: 363 D 363 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 21/129 (16%), Positives = 52/129 (40%), Gaps = 24/129 (18%) Query: 116 RLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA---DKFGD 172 ++A +DK++ ++D+ LKL + + + T++ + D+ + Sbjct: 289 FILATGSADKTVALWDL---RNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLN 345 Query: 173 VYSIDINSIPEEKFTQEPIL-----------GHVSMLTDVHLIKDSDGHQFII-TSDRDE 220 V+ D++ I EE+ + E GH + ++D + ++I + D Sbjct: 346 VW--DLSKIGEEQ-SAEDAEDGPPELLFIHGGHTAKISDFSWNPN---EPWVICSVSEDN 399 Query: 221 HIKISHYPQ 229 ++I + Sbjct: 400 IMQIWQMAE 408 >6QDV-o nrPDB Length = 513 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 38/179 (21%), Positives = 67/179 (37%), Gaps = 19/179 (10%) Query: 113 DESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA--DKF 170 D+ L SDK ++ +D+ R N I +++ + DK Sbjct: 320 DKQNLFVAGMSDKKIVQWDIRSGEIVQEYDR----HLGAVNTIVFVDENRRFVSTSDDKS 375 Query: 171 GDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQC 230 V+ DI + K+ EP + + +T L + +++ D I I Sbjct: 376 LRVWEWDIPV--DFKYIAEPSMHSMPAVT---LSPNG---KWLACQSMDNQILIFGAQNR 427 Query: 231 FIVDKW--LFGH--KHFVSSICCGKDYLLLSAG-GDDKIFAWDWKTGKNLSTFDYNSLI 284 F ++K GH + + D + +G G+ K+ WDWKT K S F + + Sbjct: 428 FRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKV 486 Score = 51.7 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 38/217 (17%), Positives = 74/217 (34%), Gaps = 30/217 (13%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 + +RL L+ D + +++V + LR SK I T Sbjct: 225 VSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRC---LRTFIGHSKAVRDICFNTAGTQF 281 Query: 165 IIA--DKFGDVYSIDINSIPEE--KFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDE 220 + A D++ ++ + + +FT + + V D D + D+ Sbjct: 282 LSAAYDRYLKLWDTET---GQCISRFT------NRKVPYCVKFNPDEDKQNLFVAGMSDK 332 Query: 221 HIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIF-AWDWKTGKNLSTFD 279 I IV ++ H V++I + + DDK W+W D Sbjct: 333 KIVQWDIRSGEIVQEYDR-HLGAVNTIVFVDENRRFVSTSDDKSLRVWEWD-----IPVD 386 Query: 280 YNSLIKPYLN---DQHLAPP----RFQNENNDIIEFA 309 + + +P ++ L+P Q+ +N I+ F Sbjct: 387 FKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFG 423 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 31/165 (18%), Positives = 62/165 (37%), Gaps = 22/165 (13%) Query: 71 NENKKLKSNKGD-SIKRTAAKVPS--PGLGAPPIYSYIRNLRLTSDESRLIACADSDKSL 127 +EN++ S D S++ +P + P ++S + + L+ + +AC D + Sbjct: 362 DENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHS-MPAVTLSPNGKW-LACQSMDNQI 419 Query: 128 LVFDVDKTSKNVLKLRKRFCFSKRPNA-----ISIAEDDTTVIIADKFGDVYSIDINSIP 182 L+F ++N +L K+ F A + + D + VI D G + D + Sbjct: 420 LIF----GAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTK 475 Query: 183 -EEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISH 226 +F + + + +IT D IK+ Sbjct: 476 LYSRFKAHDKV-------CIGAVWHPHETSKVITCGWDGLIKLWD 513 >5YZG-W nrPDB Length = 579 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 38/179 (21%), Positives = 67/179 (37%), Gaps = 19/179 (10%) Query: 113 DESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA--DKF 170 D+ L SDK ++ +D+ R N I +++ + DK Sbjct: 386 DKQNLFVAGMSDKKIVQWDIRSGEIVQEYDR----HLGAVNTIVFVDENRRFVSTSDDKS 441 Query: 171 GDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQC 230 V+ DI + K+ EP + + +T L + +++ D I I Sbjct: 442 LRVWEWDIPV--DFKYIAEPSMHSMPAVT---LSPNG---KWLACQSMDNQILIFGAQNR 493 Query: 231 FIVDKW--LFGH--KHFVSSICCGKDYLLLSAG-GDDKIFAWDWKTGKNLSTFDYNSLI 284 F ++K GH + + D + +G G+ K+ WDWKT K S F + + Sbjct: 494 FRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKV 552 Score = 51.7 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 38/217 (17%), Positives = 74/217 (34%), Gaps = 30/217 (13%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 + +RL L+ D + +++V + LR SK I T Sbjct: 291 VSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRC---LRTFIGHSKAVRDICFNTAGTQF 347 Query: 165 IIA--DKFGDVYSIDINSIPEE--KFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDE 220 + A D++ ++ + + +FT + + V D D + D+ Sbjct: 348 LSAAYDRYLKLWDTET---GQCISRFT------NRKVPYCVKFNPDEDKQNLFVAGMSDK 398 Query: 221 HIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIF-AWDWKTGKNLSTFD 279 I IV ++ H V++I + + DDK W+W D Sbjct: 399 KIVQWDIRSGEIVQEYDR-HLGAVNTIVFVDENRRFVSTSDDKSLRVWEWD-----IPVD 452 Query: 280 YNSLIKPYLN---DQHLAPP----RFQNENNDIIEFA 309 + + +P ++ L+P Q+ +N I+ F Sbjct: 453 FKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFG 489 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 31/165 (18%), Positives = 62/165 (37%), Gaps = 22/165 (13%) Query: 71 NENKKLKSNKGD-SIKRTAAKVPS--PGLGAPPIYSYIRNLRLTSDESRLIACADSDKSL 127 +EN++ S D S++ +P + P ++S + + L+ + +AC D + Sbjct: 428 DENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHS-MPAVTLSPNGKW-LACQSMDNQI 485 Query: 128 LVFDVDKTSKNVLKLRKRFCFSKRPNA-----ISIAEDDTTVIIADKFGDVYSIDINSIP 182 L+F ++N +L K+ F A + + D + VI D G + D + Sbjct: 486 LIF----GAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTK 541 Query: 183 -EEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISH 226 +F + + + +IT D IK+ Sbjct: 542 LYSRFKAHDKV-------CIGAVWHPHETSKVITCGWDGLIKLWD 579 >3JB9-L nrPDB Length = 340 Score = 52.8 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 47/175 (26%), Positives = 71/175 (40%), Gaps = 30/175 (17%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNA---ISIAEDD 161 I +L+ + D SR++ C+ SD L+ +D K+RK + NA + + + Sbjct: 96 ITDLQWSRD-SRVVYCSSSDTHLMSWDAVSGQ----KIRKHKGHAGVVNALDVLKVGSEL 150 Query: 162 TTVIIADKFGDVY---SIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDR 218 T + D V+ S D EEK+ LT V + + G Q I Sbjct: 151 LTSVSDDCTMKVWDSRSKDCIKTIEEKYP----------LTAVAIAQ--QGTQVFI-GGI 197 Query: 219 DEHIKISHYPQ--CFIVDKWLFGHKHFVSSICCGKDY-LLLSAGGDDKIFAWDWK 270 D IKI C L GHK ++S+ KD LLS D+ + +D K Sbjct: 198 DGAIKIWDLRNNHC---SHVLKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVK 249 >5Y1U-A nrPDB Length = 456 Score = 52.0 bits (123), Expect = 5e-07, Method: Composition-based stats. Identities = 20/161 (12%), Positives = 54/161 (33%), Gaps = 13/161 (8%) Query: 118 IACADSDKSLLVFDVDKTSKN--VLKLRKRF-CFSKRPNAISIAEDDTTV---IIADKFG 171 + A D ++ ++D+ K V+ + F + +S ++ + D+ Sbjct: 224 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 283 Query: 172 DVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCF 231 ++ N+ + + H + + + + T D+ + + Sbjct: 284 MIWDTRSNNTSK---PSHSVDAHTAEVNCLSFNP--YSEFILATGSADKTVALWDLRNLK 338 Query: 232 IVDKWLFGHKHFVSSICCGK--DYLLLSAGGDDKIFAWDWK 270 + HK + + + +L S+G D ++ WD Sbjct: 339 LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLS 379 Score = 40.5 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 20/129 (15%), Positives = 52/129 (40%), Gaps = 24/129 (18%) Query: 116 RLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA---DKFGD 172 ++A +DK++ ++D+ LKL + + + T++ + D+ + Sbjct: 318 FILATGSADKTVALWDL---RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLN 374 Query: 173 VYSIDINSIPEEKFTQEPIL-----------GHVSMLTDVHLIKDSDGHQFII-TSDRDE 220 V+ D++ I EE+ + E GH + ++D + ++I + D Sbjct: 375 VW--DLSKIGEEQ-SPEDAEDGPPELLFIHGGHTAKISDFSWNPN---EPWVICSVSEDN 428 Query: 221 HIKISHYPQ 229 +++ + Sbjct: 429 IMQVWQMAE 437 >6QX9-4B nrPDB Length = 522 Score = 52.0 bits (123), Expect = 5e-07, Method: Composition-based stats. Identities = 49/290 (16%), Positives = 103/290 (35%), Gaps = 52/290 (17%) Query: 29 SFKYQSPNHWEFAGKWSDDFD------KIQESRNTTAKEQQGQSSENENENKKLKSNKGD 82 ++ ++ PN + A W ++ +++E+R + ++S+ + +K L+S Sbjct: 165 TWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRS---- 220 Query: 83 SIKRTAAKVPSPGLGAPPIYSYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKL 142 + +++ G P Y + S S+++A A ++ V N+L Sbjct: 221 -LNNFCSQI---GDDRPISYCHF------SPNSKMLATACWSGLCKLWSVP--DCNLLHT 268 Query: 143 RKRFCFSKRPNAISIAEDDTTVI----------IADKFGDVYSIDINSIPEEKFTQEPIL 192 + + AI T + AD ++S+D + I Sbjct: 269 LR--GHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDE------PVADIE 320 Query: 193 GHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLF--GHKHFVSSICCG 250 GH + V +F+ T+ D ++ ++ L GH V I Sbjct: 321 GHTVRVARVMWHP---SGRFLGTTCYDRSWRLWDL---EAQEEILHQEGHSMGVYDIAFH 374 Query: 251 KDYLLLSAGGDDKI-FAWDWKTGKNLSTFDYNSLIKPYLNDQHLAPPRFQ 299 +D L GG D WD +TG+ + + + + + +P + Sbjct: 375 QDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGH---LKEIYGINFSPNGYH 421 Score = 37.0 bits (84), Expect = 0.015, Method: Composition-based stats. Identities = 30/181 (16%), Positives = 62/181 (34%), Gaps = 22/181 (12%) Query: 106 RNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVI 165 + L + L +CA D S+ ++ +D + R + + Sbjct: 285 STVSLDPKDVNLASCAA-DGSVKLWSLDSDEPVADIE----GHTVRVARVMWHPSGRFLG 339 Query: 166 IA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIK 223 D+ ++ ++ EE QE GH + D+ +D T D + Sbjct: 340 TTCYDRSWRLWDLEAQ---EEILHQE---GHSMGVYDIAFHQDG---SLAGTGGLDAFGR 390 Query: 224 ISHY--PQCFIVDKWLFGHKHFVSSICCGKDYLLLSAG-GDDKIFAWDWKTGKNLSTFDY 280 + +C + +L GH + I + ++ G GD+ WD + + + T Sbjct: 391 VWDLRTGRCIM---FLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPA 447 Query: 281 N 281 + Sbjct: 448 H 448 Score = 31.6 bits (70), Expect = 0.76, Method: Composition-based stats. Identities = 21/164 (12%), Positives = 40/164 (24%), Gaps = 55/164 (33%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 + ++ D S L D V+D+ + K I+ + + + Sbjct: 368 VYDIAFHQDGS-LAGTGGLDAFGRVWDLRTGRCIMFLE----GHLKEIYGINFSPNGYHI 422 Query: 165 I--IADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGH------------ 210 D V+ + +T I H +++T V + G+ Sbjct: 423 ATGSGDNTCKVWDLRQR---RCVYT---IPAHQNLVTGVKF-EPIHGNFLLTGAYDNTAK 475 Query: 211 -----------------------------QFIITSDRDEHIKIS 225 Q I T D K+ Sbjct: 476 IWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 >4L9O-A nrPDB Length = 349 Score = 52.0 bits (123), Expect = 6e-07, Method: Composition-based stats. Identities = 27/163 (16%), Positives = 54/163 (33%), Gaps = 16/163 (9%) Query: 117 LIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNA-----ISIAEDDTTVIIA--DK 169 ++ CA SD + + + + + + NA IS+ ++ + D Sbjct: 175 VLLCASSDGKISIVEFKDGGALEPIVIQ--GHAIGVNAASWAPISLPDNTRRFVSGGCDN 232 Query: 170 FGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQ 229 ++ D + +E GH + DV +I T+ +D + I Sbjct: 233 LVKIWRYD--DAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDG 290 Query: 230 CFIVDKWLFGHKHFVSSICCGKDYLLLS-----AGGDDKIFAW 267 + K +C + L +GGD+K+ W Sbjct: 291 KSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLW 333 >6EOJ-D nrPDB Length = 470 Score = 52.0 bits (123), Expect = 6e-07, Method: Composition-based stats. Identities = 26/168 (15%), Positives = 55/168 (32%), Gaps = 17/168 (10%) Query: 114 ESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADK--FG 171 E R + A +++ + L + + D +I D Sbjct: 104 EGRRLVVATYSGEFSLWNASSFTFETLMQ----AHDSAVTTMKYSHDSDWMISGDADGMI 159 Query: 172 DVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCF 231 ++ P +E H + D+ + +T D +KI ++ Sbjct: 160 KIWQ------PNFSMVKEIDAAHTESIRDMAFSSNDSK---FVTCSDDNILKIWNFSNGK 210 Query: 232 IVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIF-AWDWKTGKNLSTF 278 ++ L GH V S + L+++ D + WD ++G +S+ Sbjct: 211 -QERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSI 257 >5OQL-L nrPDB Length = 557 Score = 50.1 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 27/165 (16%), Positives = 56/165 (33%), Gaps = 11/165 (6%) Query: 114 ESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVI---IADKF 170 + R++ + + VFDV + ++ V+ L+ + + + T + DK Sbjct: 110 DGRVLVAGEDTGRMQVFDVGQGTRAVI-LKTWHIHKQPVWVTKWSPTELTTLMSCSDDKT 168 Query: 171 GDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQC 230 ++ + N P FT GH + + S +++ DE +++ + Sbjct: 169 VRLWDLPSND-PTRLFT-----GHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWD-ARA 221 Query: 231 FIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNL 275 F H + + L A + I D K L Sbjct: 222 PGGAVMTFKHADPIEDVLPLPSGTTLLAASGNAISVLDLVAAKPL 266 >5WJC-A nrPDB Length = 430 Score = 48.6 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 27/164 (16%), Positives = 60/164 (36%), Gaps = 16/164 (9%) Query: 118 IACADSDKSLLVFDVDKTSKNVLKLR------KRFCFSKRPNAISIAEDDTTV---IIAD 168 +A D+ + ++DV S + + K + N + + + D Sbjct: 198 LATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDD 257 Query: 169 KFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYP 228 ++ +N PEE+ + I H + V + +D + T+ D+ + + Sbjct: 258 CTLQIHDTRLN--PEEE-APKVIQAHSKAINAVAINPFNDY--LLATASADKTVALWDLR 312 Query: 229 QCFIVDKWLFGHKHFVSSICCGK--DYLLLSAGGDDKIFAWDWK 270 + L GH+ V + + +L S+ D ++ WD + Sbjct: 313 NPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLE 356 Score = 38.9 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 17/89 (19%), Positives = 33/89 (37%), Gaps = 3/89 (3%) Query: 194 HVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGK-- 251 H ++ DV + ++ D I + K + H ++++ Sbjct: 234 HTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFN 293 Query: 252 DYLLLSAGGDDKIFAWDWKTG-KNLSTFD 279 DYLL +A D + WD + + L T + Sbjct: 294 DYLLATASADKTVALWDLRNPYQRLHTLE 322 Score = 35.5 bits (80), Expect = 0.055, Method: Composition-based stats. Identities = 20/136 (14%), Positives = 49/136 (36%), Gaps = 22/136 (16%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 I + + L+A A +DK++ ++D+ + + L + + D + Sbjct: 284 INAVAINPFNDYLLATASADKTVALWDLRNPYQRLHTLE---GHEDEVYGLEWSPHDEPI 340 Query: 165 I---IADKFGDVYSIDINSIPEEKFTQEPIL-----------GHVSMLTDVHLIKDSDGH 210 + D+ ++ D+ I EE+ T E GH + +++ + Sbjct: 341 LASSSTDRRVCIW--DLEKIGEEQ-TPEDAEDGSPELLFMHGGHTNRISEFSWCPNE--R 395 Query: 211 QFIITSDRDEHIKISH 226 + + D ++I Sbjct: 396 WVVGSLADDNILQIWS 411 >4E5Z-B nrPDB Length = 436 Score = 48.2 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 37/159 (23%), Positives = 63/159 (39%), Gaps = 30/159 (18%) Query: 154 AISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFI 213 ++ ++ V+ D G+V I +N +E + + H +T V L D F+ Sbjct: 214 SLDVSASSRMVVTGDNVGNV--ILLNMDGKELWN---LRMHKKKVTHVALNPCCDW--FL 266 Query: 214 ITSDRDEHIKISHYPQCFIVDKWLFG--HKHFVSSICCGKDYL-LLSAGGDDKIFA---- 266 T+ D+ +KI Q +L+ H+H V++ C D LL+ +I Sbjct: 267 ATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSAS 326 Query: 267 -WDWKTGKNLSTFDYNSLIKPYLNDQHLAP------PRF 298 WD G + P+ + QHL P PR+ Sbjct: 327 QWDCPLGL---------IPHPHRHFQHLTPIKAAWHPRY 356 >4OWR-A nrPDB Length = 339 Score = 47.0 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 19/115 (16%), Positives = 46/115 (40%), Gaps = 13/115 (11%) Query: 114 ESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA--DKFG 171 + LIA + ++V + + + K ++ + + ++D + V A DK Sbjct: 25 GNFLIA-GSWANDVRCWEVQDSGQTIPKAQQM--HTGPVLDVCWSDDGSKVFTASCDKTA 81 Query: 172 DVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISH 226 ++ + N + I H + + +H IK + + ++T D+ +K Sbjct: 82 KMWDLSSNQAIQ-------IAQHDAPVKTIHWIK-APNYSCVMTGSWDKTLKFWD 128 Score = 44.7 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 12/92 (13%), Positives = 29/92 (31%), Gaps = 2/92 (2%) Query: 196 SMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQC-FIVDKWLFGHKHFVSSICCGKDYL 254 + + + F+I ++ + K H V +C D Sbjct: 11 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGS 70 Query: 255 -LLSAGGDDKIFAWDWKTGKNLSTFDYNSLIK 285 + +A D WD + + + +++ +K Sbjct: 71 KVFTASCDKTAKMWDLSSNQAIQIAQHDAPVK 102 >4XFV-A nrPDB Length = 792 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 26/140 (18%), Positives = 48/140 (34%), Gaps = 14/140 (10%) Query: 167 ADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKIS- 225 A K ++ P K + GH + +T V + DSD F++++ D H+KI Sbjct: 38 AGKTIALWDPIE---PNNKGVYATLKGHEAEVTCVRFVPDSD---FMVSASEDHHVKIWK 91 Query: 226 --HYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIF-AWDWKTGKNLSTFDYNS 282 Y + K + + L+S G D W + + Sbjct: 92 FTDYSHLQCIQTIQHYSK---TIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEF 148 Query: 283 LIKP-YLNDQHLAPPRFQNE 301 IK + L+ + + + Sbjct: 149 TIKKGFFYPLCLSLSKVEEK 168 Score = 32.0 bits (71), Expect = 0.50, Method: Composition-based stats. Identities = 29/151 (19%), Positives = 63/151 (41%), Gaps = 16/151 (10%) Query: 148 FSKRPNAISIAEDDTTVIIA--DKFGDVY--SIDINSIPEEKFTQEPILGHVSMLTDVHL 203 S + ++D ++ D+ ++ +++ N+ E +F E H ++ D Sbjct: 609 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTF-ELRFKNEKP--HTRIIWDADW 665 Query: 204 IKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFG---HKHFVSSICCG----KDYLLL 256 G+ F +T+ RD+ +K+ + + D L H V++I ++ +L+ Sbjct: 666 APLEFGNVF-VTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILI 724 Query: 257 SAGGDDK-IFAWDWKTGKNLSTFDYNSLIKP 286 S G ++ I+ + + GK N I P Sbjct: 725 SVGLENGEIYLYSYTLGKFELITQLNEDITP 755 >3JB9-g nrPDB Length = 558 Score = 45.9 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 20/92 (21%), Positives = 35/92 (38%), Gaps = 3/92 (3%) Query: 193 GHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKD 252 GH ++ + +++ D IKI + + GH + + +D Sbjct: 264 GHTKGISCLRFFP--ISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQD 321 Query: 253 Y-LLLSAGGDDKIFAWDWKTGKNLSTFDYNSL 283 LS D I WD + GK L+ F+ + L Sbjct: 322 GRSFLSTSFDKTIKLWDTELGKCLNCFNSDRL 353 Score = 37.4 bits (85), Expect = 0.013, Method: Composition-based stats. Identities = 31/217 (14%), Positives = 59/217 (27%), Gaps = 40/217 (18%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTS----KNVLKLRKRFCFSKRPNA----IS 156 IR+L + D ++ DK++ ++D + N +L F P+ ++ Sbjct: 313 IRDLSFSQDGRSFLST-SFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLA 371 Query: 157 IAEDDTTV---IIADKFGDVYSIDINSIPEEKF--------TQEPILGHVSM----LTDV 201 D + I + Y + I F T + Sbjct: 372 GTADKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPI 431 Query: 202 HLIKD--SDGHQFIITSDRDEHIKISHYPQCFI-----------VDKWLFGH--KHFVSS 246 + D + + I C K G+ + Sbjct: 432 KFVADIAMHSMPRVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLE 491 Query: 247 ICCGKDYLLLSAGGDDK-IFAWDWKTGKNLSTFDYNS 282 + D + +G WDWKT K ++ +S Sbjct: 492 VGFSPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHS 528 >3MKQ-A nrPDB Length = 814 Score = 45.5 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 41/242 (16%), Positives = 80/242 (33%), Gaps = 35/242 (14%) Query: 104 YIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAE--DD 161 ++ + + A D+++ V+ + +++ N + N + D Sbjct: 142 FVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTT---GQERGVNYVDYYPLPDK 198 Query: 162 TTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRD 219 +I A D ++ S T E GH+S ++ II+ D Sbjct: 199 PYMITASDDLTIKIWDYQTKS---CVATLE---GHMSNVSFAVFHP---TLPIIISGSED 249 Query: 220 EHIKISHYPQCFIVDKWLFG----------HKHFVSSICCGKD--YLLLSAGGDDKIFAW 267 +KI + + G + I G D + +LS G D+ + Sbjct: 250 GTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSL 309 Query: 268 D------WKTGKNLSTFD-YNSLIKPYLNDQHLAPPRFQNENNDIIEFAVSKIIKSKNLP 320 D W GKN + D + ++I+ + P Q + ++ + S N Sbjct: 310 DPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKELGSVDVFPQSLAHSPNGR 369 Query: 321 FV 322 FV Sbjct: 370 FV 371 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 13/91 (14%), Positives = 33/91 (36%), Gaps = 5/91 (5%) Query: 190 PILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICC 249 H + + + ++++ D +K+ ++ + +++ GH+HFV + Sbjct: 92 DFEAHPDYIRSIAVHP---TKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAF 148 Query: 250 GK-DYLLLSAGGDDKIF-AWDWKTGKNLSTF 278 D ++G D+ W T Sbjct: 149 NPKDPSTFASGCLDRTVKVWSLGQSTPNFTL 179 >2YNP-A nrPDB Length = 604 Score = 45.5 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 41/242 (16%), Positives = 80/242 (33%), Gaps = 35/242 (14%) Query: 104 YIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAE--DD 161 ++ + + A D+++ V+ + +++ N + N + D Sbjct: 142 FVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTT---GQERGVNYVDYYPLPDK 198 Query: 162 TTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRD 219 +I A D ++ S T E GH+S ++ II+ D Sbjct: 199 PYMITASDDLTIKIWDYQTKS---CVATLE---GHMSNVSFAVFHP---TLPIIISGSED 249 Query: 220 EHIKISHYPQCFIVDKWLFG----------HKHFVSSICCGKD--YLLLSAGGDDKIFAW 267 +KI + + G + I G D + +LS G D+ + Sbjct: 250 GTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSL 309 Query: 268 D------WKTGKNLSTFD-YNSLIKPYLNDQHLAPPRFQNENNDIIEFAVSKIIKSKNLP 320 D W GKN + D + ++I+ + P Q + ++ + S N Sbjct: 310 DPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKELGSVDVFPQSLAHSPNGR 369 Query: 321 FV 322 FV Sbjct: 370 FV 371 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 13/91 (14%), Positives = 33/91 (36%), Gaps = 5/91 (5%) Query: 190 PILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICC 249 H + + + ++++ D +K+ ++ + +++ GH+HFV + Sbjct: 92 DFEAHPDYIRSIAVHP---TKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAF 148 Query: 250 GK-DYLLLSAGGDDKIF-AWDWKTGKNLSTF 278 D ++G D+ W T Sbjct: 149 NPKDPSTFASGCLDRTVKVWSLGQSTPNFTL 179 >4XYI-A nrPDB Length = 430 Score = 45.1 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 27/183 (14%), Positives = 60/183 (32%), Gaps = 26/183 (14%) Query: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDT 162 + + +L+ L+ D +L + D S + + + N ++ + Sbjct: 236 AVVNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVK-AHEQPVNGVAFNPFND 294 Query: 163 TVI---IADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRD 219 ++ AD ++ D+ + + T E GH + +V ++TS D Sbjct: 295 YLLATASADHTVALW--DLRRLNQRLHTLE---GHEDEVYNVQWSP--HDEPILVTSSTD 347 Query: 220 EHIKISHYPQCFIVDK-------------WLFGHKHFVSSICCGKDYL-LLSAGGDDKIF 265 + + + GH + VS + + +L++ DD I Sbjct: 348 RRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNIL 407 Query: 266 -AW 267 W Sbjct: 408 QIW 410 Score = 38.2 bits (87), Expect = 0.008, Method: Composition-based stats. Identities = 23/119 (19%), Positives = 44/119 (36%), Gaps = 7/119 (5%) Query: 168 DKFGDVYSIDINSIPEEKFTQEPILG----HVSMLTDVHLIKDSDGHQFIITSDRDEHIK 223 D V+ I S+ EK + H +++ D+ + ++ D I Sbjct: 204 DTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTSVSDDCTLQIH 263 Query: 224 ISHYPQCFIVDKWLFGHKHFVSSICCGK--DYLLLSAGGDDKIFAWDWKT-GKNLSTFD 279 + P + + H+ V+ + DYLL +A D + WD + + L T + Sbjct: 264 DTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRLHTLE 322 >4G56-B nrPDB Length = 357 Score = 45.1 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 31/163 (19%), Positives = 62/163 (38%), Gaps = 11/163 (6%) Query: 122 DSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADK-FGDVYSI-DIN 179 S+ VF + + N ++ + ++ +D +++ I + Sbjct: 67 TWGGSIWVFKDPEGAPNESLCTAGVQTEAGVTDVAWVSEKGILVASDSGAVELWEILEKE 126 Query: 180 SIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFG 239 S+ KF + H ++ + + D ++ +D +K+ Q V K Sbjct: 127 SLLVNKFAKYE---HDDIVKTLSVFSDGTQA---VSGGKDFSVKVWDLSQ-KAVLKSYNA 179 Query: 240 HKHFVSSI--CCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFDY 280 H V+ + C GKD + LS G D +I WD + K + D+ Sbjct: 180 HSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRKPKPATRIDF 222 >6N9G-C nrPDB Length = 353 Score = 44.7 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 25/154 (16%), Positives = 52/154 (33%), Gaps = 14/154 (9%) Query: 132 VDKTSKNVLKLRKRF-CFSKRPNAISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEP 190 V+ + V+K R+ + + +D ++ + + G V D + +E P Sbjct: 45 VEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMP 104 Query: 191 ILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYP-----QCFIVDKWLFGHKHFVS 245 + + I D + K + H +++S Sbjct: 105 C----TWVMACAYAPSGCA---IACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLS 157 Query: 246 SIC-CGKDYLLLSAGGDDKIFAWDWKTGKNLSTF 278 + D +L+A GD WD ++G+ L +F Sbjct: 158 ACSFTNSDMQILTASGDGTCALWDVESGQLLQSF 191 Score = 39.7 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 24/164 (14%), Positives = 48/164 (29%), Gaps = 16/164 (9%) Query: 107 NLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVII 166 +L + + ++ DK +V+D+ N++ Sbjct: 202 DLAPSETGNTFVS-GGCDKKAMVWDMRSGQCVQAFET----HESDVNSVRYYPSGDAFAS 256 Query: 167 A--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI 224 D +Y + + + I G + V S + + D I + Sbjct: 257 GSDDATCRLYDLRADREVAIYSKESIIFG----ASSVDF---SLSGRLLFAGYNDYTINV 309 Query: 225 SHYPQCFIVDKWLFGHKHFVSSICCGKDYL-LLSAGGDDKIFAW 267 + LFGH++ VS++ D S D + W Sbjct: 310 WDVLKGS-RVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 >5OQL-d nrPDB Length = 446 Score = 44.3 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 32/170 (18%), Positives = 63/170 (37%), Gaps = 11/170 (6%) Query: 99 PPIYSYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIA 158 P I ++ E+ +I +D+S+++FD+ +T+ V+K F R + Sbjct: 194 PSFVDTITDVCFNQVETSVIGSVATDRSIILFDL-RTNMPVIKTVLHFA-CNRIVFNPME 251 Query: 159 EDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDR 218 + V D ++Y D + + Q+ GHV+ + DV + +++ Sbjct: 252 AMNLAVASEDH--NIYIFDARNFDKALNIQK---GHVAAVMDVEFSPTGEE---LVSGSY 303 Query: 219 DEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDK-IFAW 267 D I++ D + V D + G DD + W Sbjct: 304 DRTIRLWRRDAGHSRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGNVRLW 353 Score = 33.6 bits (75), Expect = 0.19, Method: Composition-based stats. Identities = 19/83 (22%), Positives = 29/83 (34%), Gaps = 3/83 (3%) Query: 186 FTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVS 245 F + GHV + + KD + I + D +K+ + H + V Sbjct: 57 FLGQLGNGHVQGV--YSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVK 114 Query: 246 SICCGKDYLLLSAGGDDKIFAWD 268 + D LLS D I WD Sbjct: 115 GLTFTNDKKLLSC-ATDGIKLWD 136 Score = 33.2 bits (74), Expect = 0.27, Method: Composition-based stats. Identities = 10/87 (11%), Positives = 31/87 (35%), Gaps = 6/87 (6%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 + ++ + L++ D+++ ++ D + KR +R D + Sbjct: 286 VMDVEFSPTGEELVS-GSYDRTIRLWRRDAGHSRDVYHTKRM---QRVFRTMWTMDSKYI 341 Query: 165 IIA--DKFGDVYSIDINSIPEEKFTQE 189 + D ++ + + K T++ Sbjct: 342 LTGSDDGNVRLWRANASERSGVKATRQ 368 >6GMH-W nrPDB Length = 305 Score = 44.0 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 31/182 (17%), Positives = 52/182 (28%), Gaps = 54/182 (29%) Query: 159 EDDTTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITS 216 E+ TV+ D V+ + Q + GH + V + S +S Sbjct: 30 ENSETVVTGSLDDLVKVWKWRDERLD----LQWSLEGHQLGVVSVDI---SHTLPIAASS 82 Query: 217 DRDEHIKISHYPQCFIVDKWLFG--------------------HKHFVS----------- 245 D HI++ + G H V+ Sbjct: 83 SLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEY 142 Query: 246 ----------SICCGKDYLLLSAGGDDKIF-AWDWKTGKNLSTFDYNSLIKPYLNDQHLA 294 SI D L++G D I +D TGK L T + +++ + + Sbjct: 143 SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAM---PIRSLTFS 199 Query: 295 PP 296 P Sbjct: 200 PD 201 Score = 41.3 bits (95), Expect = 8e-04, Method: Composition-based stats. Identities = 21/101 (20%), Positives = 42/101 (41%), Gaps = 5/101 (4%) Query: 186 FTQEPILGHVSMLTDVHLIKDSDGH-QFIITSDRDEHIKISHYPQCFIVDKW-LFGHKHF 243 F QE H + V + + + ++T D+ +K+ + + +W L GH+ Sbjct: 9 FKQE--QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLG 66 Query: 244 VSSICCGKDYLLLSAGG-DDKIFAWDWKTGKNLSTFDYNSL 283 V S+ + ++ D I WD + GK + + D + Sbjct: 67 VVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPV 107 Score = 36.6 bits (83), Expect = 0.022, Method: Composition-based stats. Identities = 23/146 (15%), Positives = 47/146 (32%), Gaps = 14/146 (9%) Query: 119 ACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFGDVYSIDI 178 A + D + ++D++ +++ ++ + D + G V Sbjct: 80 ASSSLDAHIRLWDLENGK----QIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKV----- 130 Query: 179 NSIPEEKFTQEPILGHV-SMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWL 237 N E +E L + + D +++ + D I I ++ L Sbjct: 131 NIFGVESGKKEYSLDTRGKFILSIAYSPDG---KYLASGAIDGIINIFDIATGKLLHT-L 186 Query: 238 FGHKHFVSSICCGKDYLLLSAGGDDK 263 GH + S+ D LL DD Sbjct: 187 EGHAMPIRSLTFSPDSQLLVTASDDG 212 Score = 28.5 bits (62), Expect = 6.5, Method: Composition-based stats. Identities = 23/124 (18%), Positives = 43/124 (34%), Gaps = 12/124 (9%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 IR+L + D S+L+ A D + ++DV + + ++ DDT Sbjct: 193 IRSLTFSPD-SQLLVTASDDGYIKIYDVQHANLAGTLS----GHASWVLNVAFCPDDTHF 247 Query: 165 IIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI 224 + + V D+ + T H + V + I++ D+ I I Sbjct: 248 VSSSSDKSVKVWDVGT-RTCVHT---FFDHQDQVWGVKYNGNGSK---IVSVGDDQEIHI 300 Query: 225 SHYP 228 P Sbjct: 301 YDCP 304 >3BG0-A nrPDB Length = 316 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 20/106 (18%), Positives = 35/106 (33%), Gaps = 13/106 (12%) Query: 190 PILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQ-CFIVDKWLFGHKHFVSSIC 248 + GH + V G+ + + D + I + GH V+S+C Sbjct: 52 DLRGHEGPVWQVAWAHPMYGN-ILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVC 110 Query: 249 CGKD--YLLLSAGGDDKIFA---------WDWKTGKNLSTFDYNSL 283 L+L+ G D + W+ K N T N++ Sbjct: 111 WAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAV 156 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 17/106 (16%), Positives = 36/106 (33%), Gaps = 10/106 (9%) Query: 168 DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKD-SDGHQFIITSDRDEHIKISH 226 D ++ + + +E ++ + H + DV I + +D + I Sbjct: 188 DNLIKLWKEEEDGQWKE---EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT 244 Query: 227 YPQCFIVDKW----LFGHKHFVSSICCGKDYLLLS-AGGDDKIFAW 267 + W L V + +L+ +GGD+K+ W Sbjct: 245 CDDAS-SNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 >5MWJ-A nrPDB Length = 337 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 19/71 (26%), Positives = 30/71 (42%), Gaps = 2/71 (2%) Query: 215 TSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG-DDKIFAWDWKTGK 273 + D +I + +V + GH S I D L GG D+ + +WD + G+ Sbjct: 158 SCCSDGNIAVWDLHNQTLV-RQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGR 216 Query: 274 NLSTFDYNSLI 284 L D+ S I Sbjct: 217 QLQQHDFTSQI 227 >5OQL-X nrPDB Length = 630 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 26/132 (19%), Positives = 50/132 (37%), Gaps = 13/132 (9%) Query: 147 CFSKRPNAISIAEDDTTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLI 204 K P + ++D V+ DK VY+ + P + FTQ H +T + Sbjct: 244 GHLKAPLVVKASQDGKFVVTGGADKRLVVYNA-ADLKPIKAFTQ-----HRDAVTGLAFR 297 Query: 205 KDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSI-CCGKDYLLLSAGGDDK 263 + ++ + + +D +K+ + V+ LFGH+ + I G++ + D Sbjct: 298 RGTNQ---LYSCSKDRTVKVWSLDELAYVET-LFGHQDEILDIDALGQERCVSVGARDRT 353 Query: 264 IFAWDWKTGKNL 275 W L Sbjct: 354 ARYWKVPEESQL 365 >4BZK-B nrPDB Length = 297 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 20/114 (17%), Positives = 40/114 (35%), Gaps = 10/114 (8%) Query: 167 ADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISH 226 AD ++ NS + + + GH + DV ++ + +D I Sbjct: 178 ADNLVKIWKY--NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 Query: 227 YPQCF------IVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWK-TGK 273 ++ + F + +S + +L +GGD+K+ W GK Sbjct: 236 QDNEQGPWKKTLLKEEKFPDVLWRASWSLSGN-VLALSGGDNKVTLWKENLEGK 288 >3JRP-A nrPDB Length = 379 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 20/114 (17%), Positives = 40/114 (35%), Gaps = 10/114 (8%) Query: 167 ADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISH 226 AD ++ NS + + + GH + DV ++ + +D I Sbjct: 180 ADNLVKIWKY--NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 237 Query: 227 YPQCF------IVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWK-TGK 273 ++ + F + +S + +L +GGD+K+ W GK Sbjct: 238 QDNEQGPWKKTLLKEEKFPDVLWRASWSLSGN-VLALSGGDNKVTLWKENLEGK 290 >3JRO-A nrPDB Length = 753 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 20/114 (17%), Positives = 40/114 (35%), Gaps = 10/114 (8%) Query: 167 ADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISH 226 AD ++ NS + + + GH + DV ++ + +D I Sbjct: 178 ADNLVKIWKY--NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 Query: 227 YPQCF------IVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWK-TGK 273 ++ + F + +S + +L +GGD+K+ W GK Sbjct: 236 QDNEQGPWKKTLLKEEKFPDVLWRASWSLSGN-VLALSGGDNKVTLWKENLEGK 288 >2AQ5-A nrPDB Length = 402 Score = 42.4 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 24/94 (25%), Positives = 36/94 (38%), Gaps = 10/94 (10%) Query: 193 GHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDK------WLFGHKHFVSS 246 GH + + D+ +D I + D + + P +V L GH V Sbjct: 79 GHTAPVLDIAWCPHNDN--VIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGI 136 Query: 247 ICCGK--DYLLLSAGGDDKIFAWDWKTGKNLSTF 278 + +LLSAG D+ I WD TG + T Sbjct: 137 VAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTL 170 >5FA5-B nrPDB Length = 367 Score = 42.4 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 21/113 (18%), Positives = 49/113 (43%), Gaps = 12/113 (10%) Query: 161 DTTVIIADKFG--DVYSIDIN-SIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSD 217 + +++A G +++ +D N ++ KF + H +++ V ++ ++ Sbjct: 116 ERGILVASDSGAVELWELDENETLIVSKFCKYE---HDDIVSTVSVLSSGTQA---VSGS 169 Query: 218 RDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGK--DYLLLSAGGDDKIFAWD 268 +D IK+ Q ++ + H V+ + D + LS D++I WD Sbjct: 170 KDICIKVWDLAQQVVLSSYRA-HAAQVTCVAASPHKDSVFLSCSEDNRILLWD 221 >3FM0-A nrPDB Length = 345 Score = 41.6 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 25/171 (14%), Positives = 59/171 (34%), Gaps = 21/171 (12%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 +R + + + +A A D + ++ ++ + + +++ A + Sbjct: 64 VRKVAWSPCGNY-LASASFDATTCIWKKNQDDFECVTTLE--GHENEVKSVAWAPSGNLL 120 Query: 165 I--IADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHI 222 DK V+ +D E + H + V + + ++ D+ + Sbjct: 121 ATCSRDKSVWVWEVDEEDEYECVSV---LNSHTQDVKHVVWHP---SQELLASASYDDTV 174 Query: 223 KISHYPQCFIVDKW-----LFGHKHFVSSICCGKDYLLLSAGGDDK-IFAW 267 K+ + D W L GH+ V S+ L++ DD+ + W Sbjct: 175 KLYREEE----DDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221 Score = 35.5 bits (80), Expect = 0.045, Method: Composition-based stats. Identities = 19/107 (17%), Positives = 38/107 (35%), Gaps = 8/107 (7%) Query: 167 ADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISH 226 D+ ++ + +S + E GH + V + ++ ++ D I Sbjct: 36 GDRRIRIWGTEGDSWICKSVLSE---GHQRTVRKVAWSPCGN---YLASASFDATTCIWK 89 Query: 227 YPQCFIVD-KWLFGHKHFVSSICCGKDYLLLSAGGDDK-IFAWDWKT 271 Q L GH++ V S+ LL+ DK ++ W+ Sbjct: 90 KNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDE 136 >6ELZ-p nrPDB Length = 460 Score = 41.6 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 28/156 (17%), Positives = 54/156 (34%), Gaps = 19/156 (12%) Query: 148 FSKRPNAISIAEDDTTV---IIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLI 204 + + D TV + D + + + + T S+L+ L Sbjct: 286 HTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTS------YSLLSIAQLS 339 Query: 205 KDSDGHQFIITSDRDEHIKISHY---PQCFIVDKWLFGHKHFVSSICCGKD--YLLLSAG 259 + + HI + + + L GHK+FVSS+ + Y+L S Sbjct: 340 TLNL----LACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGS 395 Query: 260 GDDKIFAWDWKTGKNLSTFDYNS-LIKPYLNDQHLA 294 D + WD ++ + T ++ +ND+ A Sbjct: 396 HDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFA 431 Score = 38.9 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 29/171 (16%), Positives = 60/171 (35%), Gaps = 28/171 (16%) Query: 74 KKLKSNKGDSIKRTAAKVPSPGLGAPPIYSYIRNLRLTSDESRLIACADSDKSLLVFDVD 133 K L S +++ T A +P L + ++ +L + D S+ I D + +D+ Sbjct: 75 KGLSSEASLNVEYTRAILPPSYLNSFSNEDWVSSLDV-GDGSKHIISGSYDGIVRTWDL- 132 Query: 134 KTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA-DKFGDVYSIDINSIP---------- 182 S NV K + S A+ + V D+ ++ + + Sbjct: 133 --SGNVQK--QYSGHSGPIRAVKYISNTRLVSAGNDRTLRLWKTKNDDLKLTSQQQAQED 188 Query: 183 -------EEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISH 226 E+ T + GH + + + + +S I+++ D I Sbjct: 189 DDDEVNIEDGKTLAILEGHKAPVVSIDVSDNSR----ILSASYDNSIGFWS 235 Score = 36.2 bits (82), Expect = 0.029, Method: Composition-based stats. Identities = 23/146 (15%), Positives = 46/146 (31%), Gaps = 35/146 (23%) Query: 146 FCFSKRPNAISIAEDDTTVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHL 203 F +++ + + +I D + + N Q+ GH + V Sbjct: 100 FSNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLSGN-------VQKQYSGHSGPIRAVKY 152 Query: 204 IKDSDGHQFIITSDRDEHIKISHYPQCFIVDKW----------------------LFGHK 241 I ++ ++++ D +++ + L GHK Sbjct: 153 ISNTR----LVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHK 208 Query: 242 HFVSSICCGKDYLLLSAGGDDKIFAW 267 V SI + +LSA D+ I W Sbjct: 209 APVVSIDVSDNSRILSASYDNSIGFW 234 Score = 31.2 bits (69), Expect = 0.85, Method: Composition-based stats. Identities = 16/80 (20%), Positives = 30/80 (37%), Gaps = 5/80 (6%) Query: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIA---E 159 +++ +L + ++ D ++ V+DV TS R+ K N A Sbjct: 376 NFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVKWA 435 Query: 160 DDTTVIIA--DKFGDVYSID 177 + +I A DK + D Sbjct: 436 EKVGIISAGQDKKIQINKGD 455 >6EM1-m nrPDB Length = 807 Score = 41.6 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 22/96 (22%), Positives = 38/96 (39%), Gaps = 4/96 (4%) Query: 234 DKWLFGHKHFVSSICCGKDYLLLSAGGDDK-IFAWDWKTGKNLS-TFDYNSLIKPYLNDQ 291 GHK V ++ L L+ G DD + W+ TG+ + T + P + + Sbjct: 430 STIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIE 489 Query: 292 HLAPPRFQNENNDIIEFAVSKIIKSKNLPFVAFFVE 327 + + NN I+ AV + I P + +E Sbjct: 490 CIEWN--PDANNGILAVAVGENIHLIVPPIFGYDIE 523 >6CB1-s nrPDB Length = 569 Score = 41.6 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 22/96 (22%), Positives = 38/96 (39%), Gaps = 4/96 (4%) Query: 234 DKWLFGHKHFVSSICCGKDYLLLSAGGDDK-IFAWDWKTGKNLS-TFDYNSLIKPYLNDQ 291 GHK V ++ L L+ G DD + W+ TG+ + T + P + + Sbjct: 192 STIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIE 251 Query: 292 HLAPPRFQNENNDIIEFAVSKIIKSKNLPFVAFFVE 327 + + NN I+ AV + I P + +E Sbjct: 252 CIEWN--PDANNGILAVAVGENIHLIVPPIFGYDIE 285 >6C0F-s nrPDB Length = 807 Score = 41.6 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 22/96 (22%), Positives = 38/96 (39%), Gaps = 4/96 (4%) Query: 234 DKWLFGHKHFVSSICCGKDYLLLSAGGDDK-IFAWDWKTGKNLS-TFDYNSLIKPYLNDQ 291 GHK V ++ L L+ G DD + W+ TG+ + T + P + + Sbjct: 430 STIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIE 489 Query: 292 HLAPPRFQNENNDIIEFAVSKIIKSKNLPFVAFFVE 327 + + NN I+ AV + I P + +E Sbjct: 490 CIEWN--PDANNGILAVAVGENIHLIVPPIFGYDIE 523 >4PSX-B nrPDB Length = 401 Score = 41.3 bits (95), Expect = 9e-04, Method: Composition-based stats. Identities = 20/186 (10%), Positives = 54/186 (29%), Gaps = 32/186 (17%) Query: 106 RNLRLTSDESRLIA----------CADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAI 155 L+ D ++ D ++ +++V +R Sbjct: 154 STLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIIND 213 Query: 156 S----IAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVH----LIKDS 207 + +D + D + + N+ + + L Sbjct: 214 NKWHNFNKDLFGTVSEDSLLKINDVRANNTT------------IDTVKCPQPFNTLAFSH 261 Query: 208 DGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGK--DYLLLSAGGDDKIF 265 + + D ++ + + GH+ V+++ D +++S+G D+++ Sbjct: 262 HSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLM 321 Query: 266 AWDWKT 271 WD K Sbjct: 322 MWDLKQ 327 Score = 31.2 bits (69), Expect = 0.84, Method: Composition-based stats. Identities = 28/177 (15%), Positives = 57/177 (32%), Gaps = 31/177 (17%) Query: 117 LIACADSDKSLLVFDVDK--TSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA---DKFG 171 L D L + DV T+ + +K + F N ++ + + ++ A D + Sbjct: 223 LFGTVSEDSLLKINDVRANNTTIDTVKCPQPF------NTLAFSHHSSNLLAAAGMDSYV 276 Query: 172 DVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCF 231 +Y + K + GH + ++ DG +++S D + + Q Sbjct: 277 YLYD-----LRNMKEPLHHMSGHEDAVNNLEFSTHVDG--VVVSSGSDNRLMMWDLKQIG 329 Query: 232 IVDKW-------------LFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNL 275 GH+ V+ L A +++ WK +L Sbjct: 330 AEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 >5CXB-B nrPDB Length = 369 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 13/51 (25%), Positives = 23/51 (45%), Gaps = 1/51 (1%) Query: 232 IVDKWLFGHKHFVSSICCGKDYLLLSAGGDDK-IFAWDWKTGKNLSTFDYN 281 + GH+ V S+ + L+ GGDD + W+ TG+ + + N Sbjct: 12 VQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLN 62 >5YZG-2 nrPDB Length = 646 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 21/73 (28%), Positives = 29/73 (39%), Gaps = 5/73 (6%) Query: 194 HVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLF-GHKHFVSSICCGKD 252 H ++T V K FIIT+ D H+K + I F H + SI + Sbjct: 89 HRDVITHVVCTKTD----FIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSE 144 Query: 253 YLLLSAGGDDKIF 265 L + GDDK Sbjct: 145 GALFCSVGDDKAM 157 Score = 34.3 bits (77), Expect = 0.097, Method: Composition-based stats. Identities = 45/199 (22%), Positives = 82/199 (41%), Gaps = 39/199 (19%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDK-TSKNVLKL-------RKRFCFSKRPNAIS 156 I ++ ++S+ + + D DK++ VFDV N+LKL +C ++++ Sbjct: 136 IESIAVSSEGALFCSVGD-DKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPGDAISSVA 194 Query: 157 IAEDDT-TVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIIT 215 +E T + I D GD + I F + H S LT + L ++ +++ Sbjct: 195 ASEKSTGKIFIYDGRGDNQPLHI-------FDKL----HTSPLTQIRLNP---VYKAVVS 240 Query: 216 SDRDEHIKISHYPQCFIV-----------DKWLFGH---KHFVSSICCGKDY-LLLSAGG 260 SD+ I+ P D L+ K + +S+C D + + G Sbjct: 241 SDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGS 300 Query: 261 DDKIFAWDWKTGKNLSTFD 279 D K+ + + TGK + FD Sbjct: 301 DRKVRIFRFVTGKLMRVFD 319 >5K19-A nrPDB Length = 569 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 26/174 (14%), Positives = 54/174 (31%), Gaps = 18/174 (10%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 + + D +AC D L VF+ D + ++ F + + D + Sbjct: 223 LNEFAFSPDGKF-LACVSQDGFLRVFNFDSVELHGT-MKSYFG---GLLCVCWSPDGKYI 277 Query: 165 IIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDS----DGHQFIITSDR 218 + D V+ S + + GH S ++ V + +G + Sbjct: 278 VTGGEDDLVTVW-----SFVDCRVIAR-GHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSD 331 Query: 219 DEHIKISHYPQCFIVDKW-LFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKT 271 ++ + H+ + ++ S Y S G D ++ WD Sbjct: 332 EDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTE 385 Score = 30.1 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 17/110 (15%), Positives = 42/110 (38%), Gaps = 8/110 (7%) Query: 203 LIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG-D 261 D +F+ +D +++ ++ + + + + +C D + GG D Sbjct: 228 FSPDG---KFLACVSQDGFLRVFNFDSVELHGT-MKSYFGGLLCVCWSPDGKYIVTGGED 283 Query: 262 DKIFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAPPRFQNENNDIIEFAVS 311 D + W + + ++ + K +++ P E D +EF+ S Sbjct: 284 DLVTVWSFVDCRVIARGHGH---KSWVSVVAFDPYTTSVEEGDPMEFSGS 330 >6CHG-A nrPDB Length = 312 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 32/130 (24%), Positives = 50/130 (38%), Gaps = 11/130 (8%) Query: 154 AISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFI 213 + I+ D + I D+ +I+S K T H + + DS + I Sbjct: 18 SCQISPDGELIAICQNT-DMLVYEISSSKMMKLTTT----HKECINCLCWSPDS---KCI 69 Query: 214 ITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDY-LLLSAGGDDKIFAWDWKTG 272 + D ++I+H I L GH V SIC +L S+ D+ I W +G Sbjct: 70 ASGSEDFTVEITHIIYGRIR--RLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSG 127 Query: 273 KNLSTFDYNS 282 L T +S Sbjct: 128 TALKTMSAHS 137 >2PM9-A nrPDB Length = 416 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 32/191 (16%), Positives = 74/191 (38%), Gaps = 14/191 (7%) Query: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLR-----KRFCFSKRPNAISI 157 S ++ ++ + + ++A ++ + ++D++K +++ + +++ Sbjct: 114 SSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAW 173 Query: 158 AEDDTTVIIA---DKFGDVYSIDINS-IPEEKFTQEPILGHVSMLTDVHLIKDSDGH-QF 212 + V + F ++ + + +T P G L+ V + Sbjct: 174 NQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTS-PNSGIKQQLSVVEWHPKNSTRVAT 232 Query: 213 IITSDRDEHIKISHYPQCFI-VDKWLFGH-KHFVSSICCGKD-YLLLSAGGDDKIFAWDW 269 SD D I I + GH K +S C +D +LLLS+G D+ + W+ Sbjct: 233 ATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNP 292 Query: 270 KTGKNLSTFDY 280 ++ + LS F Sbjct: 293 ESAEQLSQFPA 303 >6J6H-n nrPDB Length = 455 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 23/91 (25%), Positives = 39/91 (42%), Gaps = 3/91 (3%) Query: 193 GHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKD 252 GH T + + + GH I++ D IKI + + + GH + ++ +D Sbjct: 160 GHPEGTTALKFLPKT-GH-LILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTED 217 Query: 253 -YLLLSAGGDDKIFAWDWKTGKNLSTFDYNS 282 LS+ D + WD +TGK + NS Sbjct: 218 CQSFLSSSFDRSVKIWDTETGKVKTRLHLNS 248 Score = 37.8 bits (86), Expect = 0.010, Method: Composition-based stats. Identities = 37/224 (16%), Positives = 73/224 (32%), Gaps = 59/224 (26%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDD-TT 163 I+ LR T D ++ + D+S+ ++D + K++ R + P + + Sbjct: 209 IKALRFTEDCQSFLS-SSFDRSVKIWDTETG-----KVKTRLHLNSTPADVESRPTNPHE 262 Query: 164 VIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIK 223 I+ + D + + E + + H+S + + D G +FI +S D+ ++ Sbjct: 263 FIVGLSNSKILHYD-DRVSENQGLVQTYDHHLSSILALKYFPD--GSKFI-SSSEDKTVR 318 Query: 224 IS----HYPQCFIVDKWLF----------------------------------------- 238 I + P I D Sbjct: 319 IWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFK 378 Query: 239 GHK--HFVSSICCGKDYL-LLSAGGDDKIFAWDWKTGKNLSTFD 279 GH + S+ D + S ++F WDW T + L+ Sbjct: 379 GHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIK 422 Score = 32.8 bits (73), Expect = 0.31, Method: Composition-based stats. Identities = 17/126 (13%), Positives = 37/126 (29%), Gaps = 12/126 (9%) Query: 116 RLIACADSDKSLLVFDVDKTSKNVLKLRKRF-CFSKRPNAISIAEDDTTVIIA---DKFG 171 L D D L + K+ + + + A+ +I++ D Sbjct: 128 YLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTI 187 Query: 172 DVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCF 231 ++ + E GH + + +D Q ++S D +KI Sbjct: 188 KIWDFYHDY--EC---LRDFQGHNKPIKALRFTEDC---QSFLSSSFDRSVKIWDTETGK 239 Query: 232 IVDKWL 237 + + Sbjct: 240 VKTRLH 245 >5WLC-LJ nrPDB Length = 513 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 44/239 (18%), Positives = 74/239 (30%), Gaps = 27/239 (11%) Query: 72 ENKKLKSNKGDSIKR--TAAKVPSPGLGAPPIYSYIRNLRLTSDESRLIACADSDKSLLV 129 +NK L + D + R + P L Y+R L L+A D + + Sbjct: 136 DNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRL 195 Query: 130 FDV-DKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVII-ADKFGDVYSIDINSIPEEKFT 187 +D S + L +P IA T ++ V+ + N K Sbjct: 196 YDTRSSGSTPIYSLNH-----DQPVENVIAVSPTQIVSCGGNNFKVWDLTSNK----KLY 246 Query: 188 QEPILGHVSMLTDVHLIKDSDG--HQFIITSDRDEHIKISH-YPQCFIVDKWLFGHKHFV 244 + +T + +++ D +I S D H+K+ + W F V Sbjct: 247 ERGNFNKA--VTCLDYVENFDSPMQSALIASSLDGHVKVFDPLDNFQVKFGWKF--SGPV 302 Query: 245 SSICCGKDYLL----LSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAPPRFQ 299 S L AG + A K + S+ N+ N + FQ Sbjct: 303 LSCAVSPSTAQGNRHLVAGLSSGLLAIRTKKKEKRSSDKENAPASFNKNAK---SNNFQ 358 >6F1U-h nrPDB Length = 612 Score = 39.3 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 42/224 (18%), Positives = 79/224 (35%), Gaps = 23/224 (10%) Query: 77 KSNKGDSIKRTAAKVPSPGLGAPPIYSYIRNLRLTSDESRLIACADSDKSLLVFDVDKTS 136 +SNK ++RT S P+Y N+ T + LI+ +D + + +D S Sbjct: 337 RSNKRTPVQRTPL---SAAAHTHPVYCV--NVVGTQNAHNLISI-STDGKICSWSLDMLS 390 Query: 137 KNVLKLRKRFCFSKRPNAISIA---EDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILG 193 + SK S++ D ++ + G VY+ + + E G Sbjct: 391 HPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRH--GSKAGISEMFEG 448 Query: 194 HVSMLTDVHL---IKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFG---HKHFVSSI 247 H +T +H + D +TS D +K+ +K L+ + +V + Sbjct: 449 HQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKN----NKPLYSFEDNAGYVYDV 504 Query: 248 CCGKDY--LLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLN 289 + L G ++ W+ + T + P LN Sbjct: 505 MWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALN 548 >6E29-D nrPDB Length = 345 Score = 39.3 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 24/92 (26%), Positives = 35/92 (38%), Gaps = 8/92 (8%) Query: 184 EKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHF 243 E T GH T V + D F+ + D + I + K L GH Sbjct: 17 ENITNTIRSGHS---TCVRFNRKGD---FLASGRVDGTVVIWDLETMGVARK-LRGHSKN 69 Query: 244 VSSICCGKDYL-LLSAGGDDKIFAWDWKTGKN 274 ++S+ + LLSA K+ WD + GK Sbjct: 70 ITSLSWSRCGRYLLSACQGWKVILWDLQDGKR 101 >5TF2-A nrPDB Length = 407 Score = 38.9 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 12/61 (19%), Positives = 26/61 (42%), Gaps = 1/61 (1%) Query: 207 SDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFA 266 + + + T D ++++ P V ++ H+ + + G D L++ G D K Sbjct: 181 NHDNTLLATGGTDGYVRVWKVPSLEKVLEFKA-HEGEIEDLALGPDGKLVTVGRDLKASV 239 Query: 267 W 267 W Sbjct: 240 W 240 >5K0Y-T nrPDB Length = 329 Score = 38.9 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 29/136 (21%), Positives = 55/136 (40%), Gaps = 17/136 (12%) Query: 191 ILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCG 250 + GH +T + ++ D + T +D + + + + ++ GH V + Sbjct: 6 LQGHERSITQIKYNREGD---LLFTVAKDPIVNVWYSVNGERLGTYM-GHTGAVWCVDAD 61 Query: 251 KDYL-LLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAPPRFQNENNDIIEFA 309 D +L+ D+ WD +TGK L+ NS ++ D +II F+ Sbjct: 62 WDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDF----------GGNIIMFS 111 Query: 310 VSKIIKSKNLPFVAFF 325 K + + FV+FF Sbjct: 112 TDKQMGYQC--FVSFF 125 Score = 31.2 bits (69), Expect = 0.83, Method: Composition-based stats. Identities = 21/130 (16%), Positives = 46/130 (35%), Gaps = 23/130 (17%) Query: 148 FSKRPNAISIAEDDTTVIIADKFGDVYSIDINSIPEEK-FTQEPILGHVSMLTDVHLIKD 206 S++ N I ++ + T + A K D ++ +K F EP ++ + Sbjct: 187 HSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPR-------ELAALSP 239 Query: 207 SDGHQFIITSDRDEHIKISHYPQ--CFIVDKWLF-----------GHKHFVSSICCGKDY 253 + H ++ E + ++ ++ GH ++S+ D Sbjct: 240 NYEH--VVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDG 297 Query: 254 LLLSAGGDDK 263 S+GG+D Sbjct: 298 KSYSSGGEDG 307 >5L9T-R nrPDB Length = 493 Score = 38.6 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 35/183 (19%), Positives = 70/183 (38%), Gaps = 22/183 (12%) Query: 112 SDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVI-----I 166 S + +L+A +D LLV++ S AI+ + ++ Sbjct: 322 STDHQLLASGGNDNKLLVWNHSSLSPVQQYTE----HLAAVKAIAWSPHQHGLLASGGGT 377 Query: 167 ADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEH-IKIS 225 AD+ + N++ T +P+ + +L ++ + T ++ I + Sbjct: 378 ADRCIRFW----NTL-----TGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVW 428 Query: 226 HYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAG-GDDKIFAWDWKTGKNLSTFDYNSLI 284 YP V K L GH + V + D + G GD+ + W+ + K ST + S++ Sbjct: 429 KYPSLTQVAK-LTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFS-KTRSTKESVSVL 486 Query: 285 KPY 287 + Sbjct: 487 NLF 489 >5WBU-D nrPDB Length = 328 Score = 38.6 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 25/160 (15%), Positives = 53/160 (33%), Gaps = 13/160 (8%) Query: 117 LIACADSDKSLLVFDVDKTSKNVLKLRKRFCFS-KRPNAISIAEDDTTVIIADKFGDVYS 175 ++A A D ++ + + + NA+ + D ++I A + + Sbjct: 16 ILATAGYDHTVRFWQAHSGI-----CTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRM 69 Query: 176 IDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDK 235 D+NS + + V +D +++ T D +I + + Sbjct: 70 YDLNSNNPNPIISYDGVNKN--IASVGFHEDG---RWMYTGGEDCTARIWDLRSRNLQCQ 124 Query: 236 WLFGHKHFVSSICCGKDYLLLSAGGDDKIF-AWDWKTGKN 274 +F ++ +C + L G WD KT N Sbjct: 125 RIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHN 164 Score = 37.8 bits (86), Expect = 0.009, Method: Composition-based stats. Identities = 33/255 (12%), Positives = 74/255 (29%), Gaps = 63/255 (24%) Query: 92 PSPGLGAPPIYSYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKR 151 P+P + + I ++ D + + D + ++D+ L+ ++ F + Sbjct: 77 PNPIISYDGVNKNIASVGFHEDGRWMYTGGE-DCTARIWDL---RSRNLQCQRIFQVNAP 132 Query: 152 PNAISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEP--------------------- 190 N + + + +I+ D+ G ++ D+ + E+ EP Sbjct: 133 INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNS 192 Query: 191 -------------------------ILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKIS 225 I H DS + T D+ KI Sbjct: 193 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDS---TLLATCSADQTCKIW 249 Query: 226 HYPQCFIVD-------KWLFGHKHFVSSICCGKDYL-LLSAGGDDKIFAWDWKTG--KNL 275 ++ + ++ D +++A D+ W +TG K Sbjct: 250 RTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKRE 309 Query: 276 STFDYNSLIKPYLND 290 +++ ND Sbjct: 310 YGGHQKAVVCLAFND 324 Score = 32.8 bits (73), Expect = 0.34, Method: Composition-based stats. Identities = 10/64 (15%), Positives = 24/64 (37%), Gaps = 2/64 (3%) Query: 209 GHQFII-TSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAW 267 I+ T+ D ++ I + + V+++ D +++A G I + Sbjct: 12 SDPVILATAGYDHTVRFWQ-AHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMY 70 Query: 268 DWKT 271 D + Sbjct: 71 DLNS 74 >5WLC-LH nrPDB Length = 896 Score = 38.6 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 21/99 (21%), Positives = 40/99 (40%), Gaps = 6/99 (6%) Query: 214 ITSDRDEHIKIS----HYPQCFIVDKWLFGHKHFVSSICC--GKDYLLLSAGGDDKIFAW 267 +T+D + +K H + L HF +S+ +D L+ G DDK+ Sbjct: 574 LTADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSLAWSQDGSLIFHGFDDKLQIL 633 Query: 268 DWKTGKNLSTFDYNSLIKPYLNDQHLAPPRFQNENNDII 306 D+ T K + + + + D + + N+ N I+ Sbjct: 634 DFDTFKKFESLENTKTVSEFTLDSEIQTVKLINDTNLIV 672 >4AEZ-A nrPDB Length = 401 Score = 38.2 bits (87), Expect = 0.008, Method: Composition-based stats. Identities = 37/206 (17%), Positives = 81/206 (39%), Gaps = 21/206 (10%) Query: 85 KRTAAKVPSPGLGAPPIYS-YIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLR 143 KR P L AP I Y NL S+ + + ++++ V++ D S + L Sbjct: 74 KRRFNTTPERVLDAPGIIDDYYLNLLDWSNLN--VVAVALERNVYVWNADSGSVSALAET 131 Query: 144 KRFCFSKRPNAISIAEDDT--TVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDV 201 S ++ + D + +V + + D+Y ++ + + GH + + + Sbjct: 132 DE---STYVASVKWSHDGSFLSVGLGNGLVDIYDVESQT------KLRTMAGHQARVGCL 182 Query: 202 HLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGD 261 + + ++I+++ L GH V + D L L++GG+ Sbjct: 183 SWNRHVLSSGSRSGAIHHHDVRIANH-----QIGTLQGHSSEVCGLAWRSDGLQLASGGN 237 Query: 262 DKIF-AWDWKTG-KNLSTFDYNSLIK 285 D + WD ++ + ++N+ +K Sbjct: 238 DNVVQIWDARSSIPKFTKTNHNAAVK 263 >2HES-X nrPDB Length = 330 Score = 37.4 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 28/179 (15%), Positives = 68/179 (37%), Gaps = 16/179 (8%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 ++ + ++D L C DKS+ +++ D++ + + S+ + + + Sbjct: 110 VKGVAWSNDGYYLATC-SRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALL 168 Query: 165 IIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHI 222 + D ++ D + E G V +D ++G + + D + Sbjct: 169 ASSSYDDTVRIWK-DYDDDWECVAVLNGHEGTV-WSSD---FDKTEGVFRLCSGSDDSTV 223 Query: 223 KISHY-------PQCFIVDKWLFG-HKHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGK 273 ++ Y Q ++ + L HK V ++ G + L+ S G D + ++ G+ Sbjct: 224 RVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNGLIASVGADGVLAVYEEVDGE 282 >5BJS-A nrPDB Length = 605 Score = 37.4 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 10/76 (13%), Positives = 33/76 (43%), Gaps = 4/76 (5%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKT--SKNVLKLRKRFCFSKRPNAISIAEDDT 162 I +L + +IA A D ++ ++ + + + + S +++ ++ Sbjct: 181 INDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGR 240 Query: 163 TVIIA--DKFGDVYSI 176 V+ A D+ +++++ Sbjct: 241 YVLSAGHDQVINLWAL 256 >6BX3-A nrPDB Length = 314 Score = 36.6 bits (83), Expect = 0.019, Method: Composition-based stats. Identities = 32/138 (23%), Positives = 54/138 (39%), Gaps = 20/138 (14%) Query: 146 FCFSKRPNAISIAEDDTTV-IIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLI 204 C+S I+ A DD +V II +G +++ +GH + + + Sbjct: 60 LCWSPDGQCIATASDDFSVEIIHLSYGLLHTF---------------IGHTAPVISLTF- 103 Query: 205 KDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKI 264 + + TS DE IKI ++ + VS D +LS+G D + Sbjct: 104 --NRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGL 161 Query: 265 F-AWDWKTGKNLSTFDYN 281 +D +TG L T Y+ Sbjct: 162 IRIFDAETGHCLKTLTYD 179 >5WLC-LO nrPDB Length = 923 Score = 36.6 bits (83), Expect = 0.022, Method: Composition-based stats. Identities = 34/184 (18%), Positives = 68/184 (36%), Gaps = 18/184 (9%) Query: 115 SRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRP-NAISIAEDDTTVIIAD-KFGD 172 +RL+A + ++D+ L ++ + P N +S+ + + K G Sbjct: 272 TRLLAVGFTSGEFRLYDL-----PDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQ 326 Query: 173 VYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFI 232 + + S E + + GH + D ++T+ D IK+ F Sbjct: 327 LLVYEWQS---ESYILKQ-QGHFDSTNSLAYSPDGSR---VVTASEDGKIKVWDITSGFC 379 Query: 233 VDKWLFGHKHFVSSICCGKDY-LLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQ 291 + + H V+++ K ++ S+ D + AWD +N TF I+ N Sbjct: 380 LATFEE-HTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQ--FNCL 436 Query: 292 HLAP 295 + P Sbjct: 437 AVDP 440 Score = 35.5 bits (80), Expect = 0.043, Method: Composition-based stats. Identities = 27/168 (16%), Positives = 56/168 (33%), Gaps = 32/168 (19%) Query: 112 SDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFG 171 S E+ ++A A DK++ ++ + S+ V + A+S+ D V ++ G Sbjct: 482 SQENSVLASASWDKTIRIWSIFGRSQQVEPIE----VYSDVLALSMRPDGKEVAVSTLKG 537 Query: 172 DVYSIDINS-----------------IPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFII 214 + +I +++FT + T +H D I+ Sbjct: 538 QISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSE-RSKFFTTIHYSFDGMA---IV 593 Query: 215 TSDRDEHIKISHYPQCFI-------VDKWLFGHKHFVSSICCGKDYLL 255 + I + P + + L G F++S + L Sbjct: 594 AGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLEFLNSKKMTEAGSL 641 >5I2T-A nrPDB Length = 742 Score = 36.6 bits (83), Expect = 0.022, Method: Composition-based stats. Identities = 34/184 (18%), Positives = 68/184 (36%), Gaps = 18/184 (9%) Query: 115 SRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRP-NAISIAEDDTTVIIAD-KFGD 172 +RL+A + ++D+ L ++ + P N +S+ + + K G Sbjct: 297 TRLLAVGFTSGEFRLYDL-----PDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQ 351 Query: 173 VYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFI 232 + + S E + + GH + D ++T+ D IK+ F Sbjct: 352 LLVYEWQS---ESYILKQ-QGHFDSTNSLAYSPDGSR---VVTASEDGKIKVWDITSGFC 404 Query: 233 VDKWLFGHKHFVSSICCGKDY-LLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQ 291 + + H V+++ K ++ S+ D + AWD +N TF I+ N Sbjct: 405 LATFEE-HTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQ--FNCL 461 Query: 292 HLAP 295 + P Sbjct: 462 AVDP 465 Score = 35.5 bits (80), Expect = 0.043, Method: Composition-based stats. Identities = 27/168 (16%), Positives = 56/168 (33%), Gaps = 32/168 (19%) Query: 112 SDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFG 171 S E+ ++A A DK++ ++ + S+ V + A+S+ D V ++ G Sbjct: 507 SQENSVLASASWDKTIRIWSIFGRSQQVEPIE----VYSDVLALSMRPDGKEVAVSTLKG 562 Query: 172 DVYSIDINS-----------------IPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFII 214 + +I +++FT + T +H D I+ Sbjct: 563 QISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSE-RSKFFTTIHYSFDGMA---IV 618 Query: 215 TSDRDEHIKISHYPQCFI-------VDKWLFGHKHFVSSICCGKDYLL 255 + I + P + + L G F++S + L Sbjct: 619 AGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLEFLNSKKMTEAGSL 666 >5CXC-A nrPDB Length = 510 Score = 36.2 bits (82), Expect = 0.026, Method: Composition-based stats. Identities = 22/122 (18%), Positives = 35/122 (28%), Gaps = 13/122 (10%) Query: 114 ESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA-DKFGD 172 + A D L +++ + + A D D+ Sbjct: 157 GQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRTVR 216 Query: 173 VYSIDINS--IPEEKFTQE--PILGHVSMLTDVHLIKDSDGH-QFIITSDRDEHIKISHY 227 V+ + E K T E G V L D DGH + I+T+ D I Sbjct: 217 VWKYTESDHFTGELKPTLELYGHTGSVDWL-------DVDGHSKHILTASADGAIGFWSA 269 Query: 228 PQ 229 + Sbjct: 270 SK 271 Score = 33.9 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 17/103 (16%), Positives = 33/103 (32%), Gaps = 20/103 (19%) Query: 189 EPILGHVSMLTDVHLIKDSD-----------------GHQFIITSDRDEHIKISHYPQCF 231 E H ++ V ++ + G + ++++ D ++I + Sbjct: 120 EASFEHDDWVSAVDVLSATSPAGRWSSAANSSAAVQPGQERVLSASYDGLLRIWNASGSV 179 Query: 232 IVDKWLFGHKHFVSSICCGK---DYLLLSAGGDDKIFAWDWKT 271 I H +SI K L SAG D + W + Sbjct: 180 IATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRTVRVWKYTE 222 >5LCW-Q nrPDB Length = 374 Score = 36.2 bits (82), Expect = 0.028, Method: Composition-based stats. Identities = 32/197 (16%), Positives = 57/197 (28%), Gaps = 48/197 (24%) Query: 115 SRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA--DKFGD 172 S +++ + DV +V L S+ + A D + D + Sbjct: 153 SYILSSGSRSGHIHHHDVRVAEHHVATLS---GHSQEVCGLRWAPDGRHLASGGNDNLVN 209 Query: 173 VYSIDINS---IPEEKFTQ-EPILGHVSM-------------LTDVHL----------IK 205 V+ +P + FTQ + + V+ +D H+ + Sbjct: 210 VWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS 269 Query: 206 DSDGHQFIITSDRDEHIK--------------ISHYPQCFIVDKWLFGHKHFVSSICCGK 251 D H + + H K I YP L GH V S+ Sbjct: 270 AVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPT-MAKVAELKGHTSRVLSLTMSP 328 Query: 252 DYLLLSAGGDDKIF-AW 267 D +++ D+ W Sbjct: 329 DGATVASAAADETLRLW 345 Score = 32.8 bits (73), Expect = 0.30, Method: Composition-based stats. Identities = 42/214 (19%), Positives = 81/214 (37%), Gaps = 26/214 (12%) Query: 70 ENENKKLKSNKGD--SIKRTAAKVPS-PG--LGAPPIYS-YIRNLRLTSDESRLIACADS 123 +N K L S K S ++T +PS P L AP I + Y NL S + L Sbjct: 20 QNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVL--AVAL 77 Query: 124 DKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKF--GDVYSIDINSI 181 D S+ ++ +S ++L+L + + ++++ ++ + + ++ + Sbjct: 78 DNSVYLW--SASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKR 135 Query: 182 PEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSD-RDEHIKISHYPQCFIVDKWLFGH 240 + +G +S + +I++S R HI L GH Sbjct: 136 LRNMTSHSARVGSLSW------------NSYILSSGSRSGHIHHHDVRVAEHHVATLSGH 183 Query: 241 KHFVSSICCGKDYLLLSAGGDDKIF-AWDWKTGK 273 V + D L++GG+D + W G+ Sbjct: 184 SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE 217 >5G04-R nrPDB Length = 499 Score = 36.2 bits (82), Expect = 0.028, Method: Composition-based stats. Identities = 32/197 (16%), Positives = 57/197 (28%), Gaps = 48/197 (24%) Query: 115 SRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA--DKFGD 172 S +++ + DV +V L S+ + A D + D + Sbjct: 278 SYILSSGSRSGHIHHHDVRVAEHHVATLS---GHSQEVCGLRWAPDGRHLASGGNDNLVN 334 Query: 173 VYSIDINS---IPEEKFTQ-EPILGHVSM-------------LTDVHL----------IK 205 V+ +P + FTQ + + V+ +D H+ + Sbjct: 335 VWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS 394 Query: 206 DSDGHQFIITSDRDEHIK--------------ISHYPQCFIVDKWLFGHKHFVSSICCGK 251 D H + + H K I YP L GH V S+ Sbjct: 395 AVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPT-MAKVAELKGHTSRVLSLTMSP 453 Query: 252 DYLLLSAGGDDKIF-AW 267 D +++ D+ W Sbjct: 454 DGATVASAAADETLRLW 470 Score = 35.5 bits (80), Expect = 0.047, Method: Composition-based stats. Identities = 49/254 (19%), Positives = 94/254 (37%), Gaps = 29/254 (11%) Query: 33 QSPNHWEFAGKWS---DDFDKIQESRNTTAKEQQGQSSENENENKKLKSNKGD--SIKRT 87 Q+P E W+ + FD + + + Q +N K L S K S ++T Sbjct: 105 QTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKT 164 Query: 88 AAKVPS-PG--LGAPPIYS-YIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLR 143 +PS P L AP I + Y NL S + L D S+ ++ +S ++L+L Sbjct: 165 CRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVL--AVALDNSVYLW--SASSGDILQLL 220 Query: 144 KRFCFSKRPNAISIAEDDTTVIIADKF--GDVYSIDINSIPEEKFTQEPILGHVSMLTDV 201 + + ++++ ++ + + ++ + + +G +S Sbjct: 221 QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW---- 276 Query: 202 HLIKDSDGHQFIITSD-RDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG 260 + +I++S R HI L GH V + D L++GG Sbjct: 277 --------NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGG 328 Query: 261 DDKIF-AWDWKTGK 273 +D + W G+ Sbjct: 329 NDNLVNVWPSAPGE 342 >4N14-A nrPDB Length = 314 Score = 36.2 bits (82), Expect = 0.028, Method: Composition-based stats. Identities = 32/197 (16%), Positives = 57/197 (28%), Gaps = 48/197 (24%) Query: 115 SRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA--DKFGD 172 S +++ + DV +V L S+ + A D + D + Sbjct: 115 SYILSSGSRSGHIHHHDVRVAEHHVATLS---GHSQEVCGLRWAPDGRHLASGGNDNLVN 171 Query: 173 VYSIDINS---IPEEKFTQ-EPILGHVSM-------------LTDVHL----------IK 205 V+ +P + FTQ + + V+ +D H+ + Sbjct: 172 VWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS 231 Query: 206 DSDGHQFIITSDRDEHIK--------------ISHYPQCFIVDKWLFGHKHFVSSICCGK 251 D H + + H K I YP L GH V S+ Sbjct: 232 AVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPT-MAKVAELKGHTSRVLSLTMSP 290 Query: 252 DYLLLSAGGDDKIF-AW 267 D +++ D+ W Sbjct: 291 DGATVASAAADETLRLW 307 Score = 30.9 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 34/193 (17%), Positives = 70/193 (36%), Gaps = 21/193 (10%) Query: 86 RTAAKVPSPGLGAPPIYS-YIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRK 144 R +P L AP I + Y NL S + L D S+ ++ +S ++L+L + Sbjct: 3 RYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVL--AVALDNSVYLW--SASSGDILQLLQ 58 Query: 145 RFCFSKRPNAISIAEDDTTVIIADKF--GDVYSIDINSIPEEKFTQEPILGHVSMLTDVH 202 + ++++ ++ + + ++ + + +G +S Sbjct: 59 MEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW----- 113 Query: 203 LIKDSDGHQFIITSD-RDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGD 261 + +I++S R HI L GH V + D L++GG+ Sbjct: 114 -------NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGN 166 Query: 262 DKIF-AWDWKTGK 273 D + W G+ Sbjct: 167 DNLVNVWPSAPGE 179 >4GGA-A nrPDB Length = 420 Score = 36.2 bits (82), Expect = 0.028, Method: Composition-based stats. Identities = 32/197 (16%), Positives = 57/197 (28%), Gaps = 48/197 (24%) Query: 115 SRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA--DKFGD 172 S +++ + DV +V L S+ + A D + D + Sbjct: 199 SYILSSGSRSGHIHHHDVRVAEHHVATLS---GHSQEVCGLRWAPDGRHLASGGNDNLVN 255 Query: 173 VYSIDINS---IPEEKFTQ-EPILGHVSM-------------LTDVHL----------IK 205 V+ +P + FTQ + + V+ +D H+ + Sbjct: 256 VWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS 315 Query: 206 DSDGHQFIITSDRDEHIK--------------ISHYPQCFIVDKWLFGHKHFVSSICCGK 251 D H + + H K I YP L GH V S+ Sbjct: 316 AVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPT-MAKVAELKGHTSRVLSLTMSP 374 Query: 252 DYLLLSAGGDDKIF-AW 267 D +++ D+ W Sbjct: 375 DGATVASAAADETLRLW 391 Score = 35.5 bits (80), Expect = 0.047, Method: Composition-based stats. Identities = 49/254 (19%), Positives = 94/254 (37%), Gaps = 29/254 (11%) Query: 33 QSPNHWEFAGKWS---DDFDKIQESRNTTAKEQQGQSSENENENKKLKSNKGD--SIKRT 87 Q+P E W+ + FD + + + Q +N K L S K S ++T Sbjct: 26 QTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKT 85 Query: 88 AAKVPS-PG--LGAPPIYS-YIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLR 143 +PS P L AP I + Y NL S + L D S+ ++ +S ++L+L Sbjct: 86 CRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVL--AVALDNSVYLW--SASSGDILQLL 141 Query: 144 KRFCFSKRPNAISIAEDDTTVIIADKF--GDVYSIDINSIPEEKFTQEPILGHVSMLTDV 201 + + ++++ ++ + + ++ + + +G +S Sbjct: 142 QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW---- 197 Query: 202 HLIKDSDGHQFIITSD-RDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG 260 + +I++S R HI L GH V + D L++GG Sbjct: 198 --------NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGG 249 Query: 261 DDKIF-AWDWKTGK 273 +D + W G+ Sbjct: 250 NDNLVNVWPSAPGE 263 >4U1E-I nrPDB Length = 347 Score = 35.9 bits (81), Expect = 0.041, Method: Composition-based stats. Identities = 30/195 (15%), Positives = 73/195 (37%), Gaps = 17/195 (8%) Query: 84 IKRTAAKVPSPGLGAPPIYSYIRNLRL--------TSDESRLIACADSDKSLLVFDVDKT 135 I+R +A + PI+ I + L ++ +IA D + +DV Sbjct: 127 IERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIA-GHKDGKISKYDVSNN 185 Query: 136 SKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHV 195 + V + K + + + D T I + + + + +D++++ K + + Sbjct: 186 YEYVDSID---LHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKYETDCPLNT 242 Query: 196 SMLTDVH----LIKDSDGHQFIITSDRDEHIKISHYPQCFIVD-KWLFGHKHFVSSICCG 250 +++T + L + TS + + Y + F + + GH ++++ Sbjct: 243 AVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLNTVAIS 302 Query: 251 KDYLLLSAGGDDKIF 265 ++GG+D Sbjct: 303 PQGTSYASGGEDGFI 317 >5A9Q-7 nrPDB Length = 360 Score = 34.3 bits (77), Expect = 0.10, Method: Composition-based stats. Identities = 34/225 (15%), Positives = 71/225 (31%), Gaps = 42/225 (18%) Query: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 I ++ R+ C SD+S+ V+D ++ + S ++ A + Sbjct: 15 IHDVSFDFHGRRMATC-SSDQSVKVWDKSESGDWHCTASWK-THSGSVWRVTWAHPEFGQ 72 Query: 165 IIA----DKFGDVYSIDINSIPEEKFTQEPILGHVSM------------LTDVHLIKDSD 208 ++A D+ V+ + + + + G +TDV Sbjct: 73 VLASCSFDRTAAVWEEIVGE------SNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHM 126 Query: 209 GHQFIITSDRDEHIKISHYPQCFIVDKWLFGH----KHFVSSICCGKDYL-----LLSAG 259 G + T D ++I P + +W H K S I +++ G Sbjct: 127 G-LMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVG 185 Query: 260 GDD-------KIFAWDWKTGKNLST-FDYNSLIKPYLNDQHLAPP 296 DD K+ +++ + + ++D AP Sbjct: 186 SDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPN 230 >3F3P-A nrPDB Length = 351 Score = 34.3 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 32/158 (20%), Positives = 58/158 (36%), Gaps = 26/158 (16%) Query: 166 IADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKIS 225 +D+ V+ +D ++ E + H S + + G I ++ D+ +K+ Sbjct: 30 SSDQHIKVFKLDKDTSNWE--LSDSWRAHDSSIVAIDWASPEYGR-IIASASYDKTVKLW 86 Query: 226 ----HYPQCFIVDKW-----LFGHKHFVSSICCGKD--YLLLSAGGDDKIF-AWDWKTGK 273 +C +W L K + S+ L L+ G+D I +D Sbjct: 87 EEDPDQEECSGR-RWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPS 145 Query: 274 NLSTFDYNSLIK----PYLN----DQHLA--PPRFQNE 301 +L ++ S +K P N D L+ P RF E Sbjct: 146 DLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPE 183 Score = 30.9 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 17/82 (20%), Positives = 30/82 (36%), Gaps = 9/82 (10%) Query: 193 GHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHY----PQCFIVDKWLFGHKHFVSSIC 248 GH ++ DV + + T D+HIK+ + D W V+ Sbjct: 9 GHDDLVHDVVY---DFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW 65 Query: 249 CGKDY--LLLSAGGDDKIFAWD 268 +Y ++ SA D + W+ Sbjct: 66 ASPEYGRIIASASYDKTVKLWE 87 >5Z56-q nrPDB Length = 504 Score = 33.9 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 23/162 (14%), Positives = 50/162 (30%), Gaps = 14/162 (8%) Query: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDT 162 S + L L + L++ +D D+ D+ + S D Sbjct: 307 SAVTGLSLHATGDYLLSSSD-DQYWAFSDIQTGRVLTKVTDETSGCS--LTCAQFHPDGL 363 Query: 163 TVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDE 220 D ++ + +E+ GH +T + ++ ++ T+ D Sbjct: 364 IFGTGTMDSQIKIWDL------KERTNVANFPGHSGPITSIAFSENGY---YLATAADDS 414 Query: 221 HIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDD 262 +K+ + + V S+ + L+ GG D Sbjct: 415 SVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD 456 >4LG8-A nrPDB Length = 354 Score = 33.9 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 23/162 (14%), Positives = 50/162 (30%), Gaps = 14/162 (8%) Query: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDT 162 S + L L + L++ +D D+ D+ + S D Sbjct: 157 SAVTGLSLHATGDYLLSSSD-DQYWAFSDIQTGRVLTKVTDETSGCS--LTCAQFHPDGL 213 Query: 163 TVIIA--DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDE 220 D ++ + +E+ GH +T + ++ ++ T+ D Sbjct: 214 IFGTGTMDSQIKIWDL------KERTNVANFPGHSGPITSIAFSENGY---YLATAADDS 264 Query: 221 HIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDD 262 +K+ + + V S+ + L+ GG D Sbjct: 265 SVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD 306 >1PI6-A nrPDB Length = 615 Score = 33.9 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 47/267 (17%), Positives = 96/267 (35%), Gaps = 26/267 (9%) Query: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDT 162 S++R++ + D + SD+ + FD + A+S + Sbjct: 207 SFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQK 266 Query: 163 -TVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEH 221 + AD V+ + + + K+T + + V + G+ II+ D Sbjct: 267 FATVGADATIRVWDVTTSKCVQ-KWTLDKQQLGNQQVGVV-----ATGNGRIISLSLDGT 320 Query: 222 IKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFDYN 281 + ++ K + GH ++++ L+S D +I W + D++ Sbjct: 321 LNFYELGHDEVL-KTISGHNKGITALTVNP---LISGSYDGRIMEWSSSSMHQ----DHS 372 Query: 282 SLIKPYLN--DQHLAPPRFQN--ENNDII--EFAVS-KIIKSKNLPFVAFFVEATKCIII 334 +LI N Q + + + + N I EF K+ + N F A +I+ Sbjct: 373 NLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLIL 432 Query: 335 LEMSEKQKGDLALKQIITFPYNVISLS 361 + GD+ + P + +SLS Sbjct: 433 QSFT----GDIIKSVRLNSPGSAVSLS 455 Score = 32.0 bits (71), Expect = 0.53, Method: Composition-based stats. Identities = 42/207 (20%), Positives = 80/207 (38%), Gaps = 27/207 (13%) Query: 69 NENENKKLKSNKGDSIKRTAAKVPSPGLGAPPIYSYIRNLRLTSDESRLIACADSDKSLL 128 N+++ L+S GD IK + ++ SPG +Y+ + ++ + Sbjct: 425 NDDDLLILQSFTGDIIK--SVRLNSPGSAVSLSQNYVA---------VGLEEGNTIQVFK 473 Query: 129 VFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQ 188 + D++ + LR + P+ ISI+ +T + D G + D+ S E K ++ Sbjct: 474 LSDLEVSFDLKTPLRAK------PSYISISPSETYIAAGDVMGKILLYDLQS-REVKTSR 526 Query: 189 EPILGHVSMLTDVHLIKDSDG-------HQFIITSDRDEHIKISHYPQCFIVDKWLFGHK 241 S + + G + T D +I I + + K L HK Sbjct: 527 WAF--RTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHK 584 Query: 242 HFVSSICCGKDYLLLSAGGDDKIFAWD 268 V+++ L+S+G D I W+ Sbjct: 585 DGVNNLLWETPSTLVSSGADACIKRWN 611 >3W15-A nrPDB Length = 368 Score = 33.2 bits (74), Expect = 0.26, Method: Composition-based stats. Identities = 16/132 (12%), Positives = 51/132 (38%), Gaps = 23/132 (17%) Query: 116 RLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNA-------ISIAEDDTTVIIA- 167 ++A D ++ ++D+ +KN +L C ++ PNA ++ + + ++++ Sbjct: 236 YVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSA 295 Query: 168 --DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSD----------GHQ-FII 214 D ++ N +E + + + + S+ G ++ Sbjct: 296 SYDMTCRIWRDLSNDGAKETYKTNSTDATKG--SIFNFTQHSEFVFGADWSLWGKPGYVA 353 Query: 215 TSDRDEHIKISH 226 ++ D ++ + + Sbjct: 354 STAWDGNLFVWN 365 >5MC6-j nrPDB Length = 397 Score = 32.4 bits (72), Expect = 0.40, Method: Composition-based stats. Identities = 15/43 (34%), Positives = 22/43 (51%), Gaps = 1/43 (2%) Query: 238 FGHKHFVSSICCGKDY-LLLSAGGDDKIFAWDWKTGKNLSTFD 279 F H +V S+ L SAG D K+ WD KT + ++T + Sbjct: 288 FAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLN 330 Score = 31.6 bits (70), Expect = 0.65, Method: Composition-based stats. Identities = 17/119 (14%), Positives = 45/119 (37%), Gaps = 6/119 (5%) Query: 112 SDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFG 171 ++ + I+ + + L F+ + N + FS + + ++IA D + + Sbjct: 205 NNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLAIAHDSNSFGCITLYE 264 Query: 172 DVYSIDINSIPEEKFTQEPILG---HVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHY 227 + I S+ + + LG H S + + +D + + ++ D ++ Sbjct: 265 TEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSF---NDSGETLCSAGWDGKLRFWDV 320 >5A31-R nrPDB Length = 386 Score = 32.0 bits (71), Expect = 0.51, Method: Composition-based stats. Identities = 16/78 (20%), Positives = 35/78 (44%), Gaps = 9/78 (11%) Query: 103 SYIRNLRLTSDESRLI-ACADSDKSLLVFDVDKTSK-NVLKLRKRFCFSKRPNAISIAED 160 S I N+ + + + L+ + S +L ++D + +LK S R ++++ D Sbjct: 301 SQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILK-----GHSFRVLHLTLSND 355 Query: 161 DTTVII--ADKFGDVYSI 176 TTV+ D+ + + Sbjct: 356 GTTVVSGAGDETLRYWKL 373 >4BH6-A nrPDB Length = 308 Score = 32.0 bits (71), Expect = 0.51, Method: Composition-based stats. Identities = 16/78 (20%), Positives = 35/78 (44%), Gaps = 9/78 (11%) Query: 103 SYIRNLRLTSDESRLI-ACADSDKSLLVFDVDKTSK-NVLKLRKRFCFSKRPNAISIAED 160 S I N+ + + + L+ + S +L ++D + +LK S R ++++ D Sbjct: 232 SQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILK-----GHSFRVLHLTLSND 286 Query: 161 DTTVII--ADKFGDVYSI 176 TTV+ D+ + + Sbjct: 287 GTTVVSGAGDETLRYWKL 304 >5WLC-LU nrPDB Length = 489 Score = 32.0 bits (71), Expect = 0.54, Method: Composition-based stats. Identities = 12/89 (13%), Positives = 29/89 (32%), Gaps = 6/89 (6%) Query: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDT 162 S + ++ + ++ DKS+ ++ + + KR + + D Sbjct: 306 SAVMDVDFSPTGDEIVT-GSYDKSIRIYKTNHGHSREIYHTKRMQH---VFQVKYSMDSK 361 Query: 163 TVIIA--DKFGDVYSIDINSIPEEKFTQE 189 +I D ++ K T+E Sbjct: 362 YIISGSDDGNVRLWRSKAWERSNVKTTRE 390 Score = 28.5 bits (62), Expect = 5.6, Method: Composition-based stats. Identities = 23/136 (16%), Positives = 41/136 (30%), Gaps = 30/136 (22%) Query: 166 IADKFGDVYSIDINSIPEEKFTQEPILGHVSMLT--DV---HL---IKDSDGHQFIITSD 217 AD + N E+F H ++T V D F+++ Sbjct: 87 SADGVIKYW----NMSTREEFVS--FKAHYGLVTGLCVTQPRFHDKKPDLKSQNFMLSCS 140 Query: 218 RDEHIKIS-----HYPQCFIVDK-WLFGHKHFVSS---------ICCGKDYLLLSAGGDD 262 D+ +K+ Y D + + + + I ++ + GG Sbjct: 141 DDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQGIDSHRENSTFATGG-A 199 Query: 263 KIFAWDWKTGKNLSTF 278 KI WD K +S Sbjct: 200 KIHLWDVNRLKPVSDL 215 >2P9P-C nrPDB Length = 372 Score = 31.6 bits (70), Expect = 0.79, Method: Composition-based stats. Identities = 17/83 (20%), Positives = 33/83 (39%), Gaps = 16/83 (19%) Query: 147 CFS--KRPNAISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLI 204 C + K I+I ++ V I +K G+ + + ++ + E H +T V Sbjct: 13 CHAWNKDRTQIAICPNNHEVHIYEKSGNKW-VQVHELKE----------HNGQVTGVDWA 61 Query: 205 KDSDGHQFIITSDRDEHIKISHY 227 DS+ I+T D + + Sbjct: 62 PDSNR---IVTCGTDRNAYVWTL 81 >5LTD-A nrPDB Length = 525 Score = 31.2 bits (69), Expect = 0.97, Method: Composition-based stats. Identities = 13/63 (20%), Positives = 26/63 (41%), Gaps = 2/63 (3%) Query: 108 LRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA 167 + L+ D L +D + VF V K L +R + + +++ + D+ VI + Sbjct: 228 IALSKDGLLLATASDKGTIIRVFSVATGIK--LYQFRRGTYPTKIYSLAFSPDNRFVIAS 285 Query: 168 DKF 170 Sbjct: 286 SAT 288 Score = 30.9 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 24/63 (38%), Gaps = 4/63 (6%) Query: 239 GHKHFVSSICCGKDYLLLSAGGDDKIFA--WDWKTGKNLSTFDYNSLIKPYLNDQHLAP- 295 H+ +++I KD LLL+ D + TG L F + + +P Sbjct: 220 AHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTY-PTKIYSLAFSPD 278 Query: 296 PRF 298 RF Sbjct: 279 NRF 281 >3JZG-A nrPDB Length = 402 Score = 30.9 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 11/91 (12%), Positives = 30/91 (32%), Gaps = 9/91 (9%) Query: 147 CFSKRPNAISIAEDDTTV---IIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHL 203 N + D + + D +++I +++ + GH + Sbjct: 149 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVA---IFGGVEGHRDEVLSADY 205 Query: 204 IKDSDGHQFIITSDRDEHIKISHYPQCFIVD 234 D G + I++ D +K+ +++ Sbjct: 206 --DLLGEK-IMSCGMDHSLKLWRINSKRMMN 233 >3EI3-B nrPDB Length = 383 Score = 30.9 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 20/109 (18%), Positives = 38/109 (34%), Gaps = 16/109 (14%) Query: 194 HVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFG--HKHFVSSICCGK 251 H + +T D + TS D +K+ + ++ H+ V++ Sbjct: 203 HKAKVTHAEFNPRCDW--LMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNP 260 Query: 252 DYL--LLSAGGDDKIFA---WDWKTGKNLSTFDYNSLIKPYLNDQHLAP 295 LL+ ++I +DW + +I P+ QHL P Sbjct: 261 TDSTKLLTTDQRNEIRVYSSYDWSKPDQI-------IIHPHRQFQHLTP 302 >5WYJ-BE nrPDB Length = 939 Score = 30.5 bits (67), Expect = 1.7, Method: Composition-based stats. Identities = 10/66 (15%), Positives = 27/66 (40%), Gaps = 5/66 (7%) Query: 193 GHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKD 252 GH + +T + ++I+++ D I+ P +D + + +++ + Sbjct: 583 GHSNRITAFDFSPEG---RWIVSASLDSTIRTWDLPTGGCIDGIIV--DNVATNVKFSPN 637 Query: 253 YLLLSA 258 LL+ Sbjct: 638 GDLLAT 643 >5TOS-A nrPDB Length = 395 Score = 29.3 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 12/45 (26%), Positives = 19/45 (42%), Gaps = 5/45 (11%) Query: 181 IPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIIT----SDRDEH 221 I +K QE GH LT+++ + H ++ DEH Sbjct: 102 IAVKKLNQEGFQGHREWLTEINYL-GQLSHPNLVKLIGYCLEDEH 145 >5W5F-A nrPDB Length = 163 Score = 29.3 bits (64), Expect = 3.2, Method: Composition-based stats. Identities = 19/75 (25%), Positives = 37/75 (49%), Gaps = 2/75 (2%) Query: 365 DEFQVTLDNKESSGVQKNFAKFIEYNLNENSFVVNNEKSNEFDSAIIQSVQGDSNLVTKK 424 D++ VT+ N E+ ++ F + + + + + + SAI++ D+ VTK+ Sbjct: 67 DDWTVTVMNDEAHDARQKFVDWQSIAAGQGNEITGGKPAEYKKSAIVRQYARDAKTVTKE 126 Query: 425 EEIYPLY--NVSSLR 437 EI L+ NV L+ Sbjct: 127 IEIKGLWPTNVGELQ 141 >2I3T-A nrPDB Length = 341 Score = 29.3 bits (64), Expect = 3.7, Method: Composition-based stats. Identities = 13/65 (20%), Positives = 24/65 (36%), Gaps = 4/65 (6%) Query: 198 LTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLS 257 + + H+F+ T+ D I + + + ++ V I C D +L Sbjct: 254 VNSIEFSP---RHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACS-DNILCL 309 Query: 258 AGGDD 262 A DD Sbjct: 310 ATSDD 314 >3HK0-A nrPDB Length = 256 Score = 28.9 bits (63), Expect = 4.0, Method: Composition-based stats. Identities = 12/69 (17%), Positives = 24/69 (34%), Gaps = 14/69 (20%) Query: 247 ICCGKDYLLLSAGGDDKI-----FAWDWKTGKNLSTF-----DYNSLIKPYLNDQHLAPP 296 +C + L S G D + N+ + YN+ P + + P Sbjct: 153 VCLRRSGLYCSTKGTSAAPRHLQLLADLED-SNIFSLIAGRKQYNA---PTDHGLCIKPN 208 Query: 297 RFQNENNDI 305 + +NE ++ Sbjct: 209 KVRNETKEL 217 >4NC4-A nrPDB Length = 377 Score = 28.9 bits (63), Expect = 4.6, Method: Composition-based stats. Identities = 11/77 (14%), Positives = 24/77 (31%), Gaps = 5/77 (6%) Query: 171 GDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQC 230 G +Y N KF Q + ++ + V + D ++ + ++ Sbjct: 283 GKLYGWGWN-----KFGQVGVGNNLDQCSPVQVRFPDDQKVVQVSCGWRHTLAVTERNNV 337 Query: 231 FIVDKWLFGHKHFVSSI 247 F + G S+ Sbjct: 338 FAWGRGTNGQLGIGESV 354 >5WLC-LN nrPDB Length = 776 Score = 28.9 bits (63), Expect = 4.8, Method: Composition-based stats. Identities = 28/169 (16%), Positives = 62/169 (36%), Gaps = 10/169 (5%) Query: 112 SDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVI-IADKF 170 +D ++ + ++++ D+ + R ++ +DD + +D Sbjct: 150 NDSQDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDDFVIGGCSDGR 209 Query: 171 GDVYSIDIN--SIPEEKFTQ--EPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISH 226 ++S N ++ T + +++ V + +D I + D IK Sbjct: 210 IRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQ---IASGDSTGSIKFWD 266 Query: 227 YPQCFIVDKWLFGHKHFVSSICCGKDYL-LLSAGGDDKIFAWDWKTGKN 274 + Q +++ H V + D + SAG D KIF + T K+ Sbjct: 267 F-QFATLNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKS 314 >4V1Z-A nrPDB Length = 440 Score = 28.2 bits (61), Expect = 7.4, Method: Composition-based stats. Identities = 9/73 (12%), Positives = 27/73 (36%), Gaps = 10/73 (13%) Query: 187 TQEPILGHVSMLTDVHLIKDSDGH-QFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVS 245 +Q + ++ + + + + +I ++ K+ Y C+ + W + Sbjct: 6 SQAEVHPSMTWQSCTAGGSCTTNNGKVVIDANWRWVHKVGDYTNCYTGNTWD-------T 58 Query: 246 SICCGKDYLLLSA 258 +IC D ++ Sbjct: 59 TIC--PDDATCAS 69 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.313 0.129 0.358 Lambda K H 0.267 0.0401 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,949,631 Number of Sequences: 36641 Number of extensions: 674226 Number of successful extensions: 2555 Number of sequences better than 10.0: 122 Number of HSP's better than 10.0 without gapping: 67 Number of HSP's successfully gapped in prelim test: 101 Number of HSP's that attempted gapping in prelim test: 2008 Number of HSP's gapped (non-prelim): 387 length of query: 444 length of database: 10,336,785 effective HSP length: 100 effective length of query: 344 effective length of database: 6,672,685 effective search space: 2295403640 effective search space used: 2295403640 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 61 (28.1 bits)